bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the effectiveness of countering doping in sports in the framework of medical and biological support for athletes of national teams
Authors: Derevoedov A. A. , Zholinsky A. V. , Feshchenko V. S. , Vykhodets I. T. , Pavlova A. A.
Published: March 2023

Objective: analysis of the effectiveness of combating doping in sports in the process of medical and biological support of athletes forming the national teams of the Russian Federation, and determining its ways.

Materials and methods: based on the reports of anti-doping organizations for 2017–2022, sociological studies of the prevalence of doping in sports and therapeutic use structures, a retrospective analysis of the dynamics of the main indicators reflecting the directions of various doping encounters was carried out.

Results: a significant discrepancy was revealed between the assessment of the prevalence of anti-doping rule violations based on the results of sociological surveys and the results of laboratory anti-doping studies.

A significant positive dynamic of approval of therapeutic use exemptions, which allowed doubling the share of positive decisions of anti-doping organizations is shown.

The main directions of improving anti-doping work in the process of carrying out medical and biological support measures are determined.
Improving the indicators of schoolchildren’s adaptation to physical activity using an individual approach, taking into account the types of vegetative regulation
Authors: Gorelik V. V. , Filippova S. N. , Nazarenko N. N.
Published: March 2023

Purpose: physiological substantiation of the physical activity selection based on the differences in the functional state of schoolchildren with different types of cardiovascular system autonomic regulation.

Methods: 60 schoolchildren, 12 years old, were examined. The experimental group consisted of schoolchildren who were engaged in physical exercises for 6 months according to the developed individual typological program. Students in the control group followed the school programm. The assessment of the functional state was carried out by the method of “Express assessment of the physical health of schoolchildren” and the method of diagnosing indicators of heart rate variability.

Results: at the beginning of the survey, the indicators in the experimental group and the control group were determined by the characteristics of 4 types of autonomic regulation: I, II, III, IV. Of these, I, II corresponded to the predominance of sympathetic-tonic destabilizing influences on the cardiovascular system, in IV parasympathetic influences prevailed, manifested in the asthenia of the functional state of students. Whereas type III refers to the physiological norm and manifested itself in the form of a balance of regulatory influences of the parts of the autonomic nervous system.

Conclusions: at the control examination, the indicators of adaptation and health improved in all types of schoolchildren, while in the control group there was no positive dynamics of indicators of adaptation and health. This testifies to the effectiveness of individually typologically oriented classes at a physical education lesson as having a health-improving effect on schoolchildren.
Lectura y escritura como estrategia didáctica desde la función docente universitaria
Authors: Rangel de Montero Brígida Siolet
Published: March 2023

El Proyecto Sociointegrador tiene como objetivo analizar la integración de la lectura y escritura como estrategia didáctica desde la función docente para el fortalecimiento en la formación académica de los Programas Nacionales de Formación (PNF) Cefounes Guárico. Para el logro del objetivo debe asumirse una revisión bibliográfica aunado a la interpretación de contenidos. Las Técnicas de recolección de la Información fue las fichas descriptivas y se empleó el análisis de contenido como técnica de análisis de los resultados. Se concluye que la universidad es una institución más en el entramado de las organizaciones sociales que dan paso a la formación del individuo como ser social, que debe propiciar su fortalecimiento académico como docente en formación en el marco de los PNF empleando para ella la integración de la lectura y la escritura como estrategia didáctica.
Loon naar werken, ook voor artsen: enkele reflecties over billijke artsenhonoraria
Authors: Demyttenaere B. , van den Oever R. , Claeys D.
Published: March 2023

Paying the deserved reward, also to the doctor

There are several ways of financing health care and health care providers. Three experts, each with considerable experience in Belgian health care, reflect on the crucial questions and submit arguments to change the existing principles of paying the doctor. They make an inventory of basic keynotes and assumptions, and present an overview of the possible options. Finally, the authors opt for a modern system of mixed financing (fee-for-service and forfaitary payments), adapted to general practitioners and the several specialistic disciplines. In their conclusions, they suggest a spectrum of deducted possible financial decisions enabling the combination of the doctors’ deserved reward with options that could be important for the future Belgian health care.
Self-Concept and Learning Achievement of Mathematics Education College Student
Authors: Baiduri Baiduri
Published: March 2023

Self-concept is one important factor in one's success, especially in education. This study aims to describe and analyze the relationship between students' self-concept in learning mathematics and mathematics learning achievement, and investigate the significance of differences in self-concept and learning achievement in mathematics education students seen from that semester. A total of 151 mathematics education students at the Teaching and Education Faculty of the University of Muhammadiyah Malang were used as participants in this study. Self-concept data and mathematics learning achievement were obtained through an online questionnaire using Google Forms. Descriptive statistics, correlation tests, and ANOVA tests were used in analyzing the data. Descriptions of self-concept and student achievement are presented per category and semester. Correlational analysis shows a very weak relationship between self-concept and student achievement. The results of the ANOVA test prove that there is no significant difference in self-concept in terms of student semesters. As for learning achievement there is a significant difference based on student semester.
Qualitative Study: Analysis of Interpersonal Relationships of Female Students Using the Niqab
Authors: Dahrul Annida , Widita Cintya Sukma , Sufti Muflihah Awaliyah , Wulandari Sekar Dwi , Agustian Eva
Published: March 2023

The purpose of this interpersonal relationship analysis is to make the community have an overview of the interpersonal relationships of female students who choose to wear the veil. It can be seen from the motives, factors and environmental responses to the choice of the subject who chooses to wear the veil. This study uses a qualitative approach to interpretive phenomenology. The technique used in this research uses in-depth interviews and observation. The research results show a specific picture of how the subject establishes interpersonal relationships with the environment both from a psychological and social perspective. Based on the research results, it can be seen that each subject has different problems in interpersonal relations, both from within or psychological aspects or problems from the perspective or perspective of the environment and the surrounding community.
Türkiye’de Netflix Dizilerini Aşırı İzleme [Binge-Watching] Motivasyonları Üzerine Bir Araştırma
Authors: ERSİN Nimet
Published: March 2023

Bu araştırma, Türkiye’de Netflix dizilerinin “aşırı izleme” [binge-watching]davranışının motivasyonlarını ortaya koymak amacıyla yapılmıştır. Çalışmanın kuramsal temelini Kullanımlar ve Doyumlar yaklaşımı oluşturmaktadır. Araştırma uygulamalı bir araştırma olup, nicel araştırma yöntemi kullanılmıştır. Araştırmanın evreni Türkiye’de yer alan Netflix kullanıcılarıdır. Çevrimiçi uygulanan, 441 anket formu verisi üzerinden araştırmanın analizleri gerçekleştirilmiştir. Araştırmada aşırı izleme davranışı değişkenini ölçmek amacıyla Flayelle, Canale, Vögele, Karila, Maurage ve Billieux (2019) tarafından geliştirilmiş olan ölçekten yararlanılmıştır. Diğer yandan araştırmanın konusu kapsamında incelenen Netflix dizilerini aşırı izlemeyi etkileyen unsurlar olan sosyal etkileşim, eğlence, zaman geçirme, rahatlama, kaçış, bilgi ve alışkanlık değişkenlerini ölçmede Sung, Kang ve Lee (2018) tarafından kullanılan ölçekler kullanılmıştır. Araştırmada kullanılan ölçeklerin tümü 5’li Likert tipinde ölçülmüştür. Araştırma kapsamında frekans analizleri, güvenilirlik, geçerlilik ve regresyon analizleri gerçekleştirilmiştir. Araştırma sonunda sosyal etki, eğlence ve rahatlama, zaman geçirme ve kaçış ile alışkanlık değişkenlerinin Netflix dizilerini aşırı izlemeyi etkilediği ortaya çıkmıştır.
Degradation of Ciprofloxacin (CIP) Antibiotic Waste using The Advanced Oxidation Process (AOP) Method with Ferrate (VI) from Extreme Base Electrosynthesis
Authors: Gunawan Gunawan , Prasetya Nor Basid Adiwibawa , Wijaya Roni Adi
Published: March 2023

Ciprofloxacin (CIP) antibiotic liquid waste is the most common waste found in hospital discharge waters. The accumulation of CIP can increase mutation, microbial resistance, and toxicity in the environment due to its low biodegradability and longevity in waters. Thus, methods for eliminating CIP are important. The Advanced Oxidation Process (AOP) method with ferrate (VI) has good redox potential in water disinfection, and degradation of organic and inorganic pollutants. Therefore, this study aims to degrade CIP waste with ferrate (VI). The ferrate (VI) used was synthesized from the electrolysis of transformer scrap metal plates under extremely alkaline conditions. The success of the synthesis was proven by the presence of FeO(OH) groups characterized using FTIR, XRF, and XRD. Then, the effect of time, pH, and CIP degradation was studied. The results showed that the maximum performance was obtained at pH 7 and 120 min with the addition of 1.1 mg ferrate at initial CIP concentration of 30 mg/L. The concentration of CIP decreased with increasing treatment time which was confirmed by UV-Vis Spectrophotometer. This condition is able to degrade 86.7 % of CIP. In addition, the LC-MS results show that degradation occurs due to a reaction between HFeO4-/H2FeO4 and the active site of piperazine ring antibiotics. This shows that Ferrate has a promising potential to reduce ciprofloxacin antibiotic pollution from hospital wastewater for a better environment.
HIGHLIGHTS

Ciprofloxacin (CIP) antibiotic liquid waste is the most common waste found in hospital discharge waters. It can cause mutation, microbial resistance, and toxicity in the environment due to its low biodegradability and longevity in waters
The Advanced Oxidation Process (AOP) method with ferrate (VI) has good redox potential in water disinfection, and degradation of organic and inorganic pollutants including antibiotic liquid waste
Ferrate was able to degrade 86.7 % of ciprofloxacin antibiotic pollution from hospital wastewater through a reaction between HFeO4-/H2FeO4 and the active site of piperazine ring antibiotics

GRAPHICAL ABSTRACT
Teilentwarnung für Tierhalter
Authors: Mönch Axel
Published: March 2023

Brüssel. Die EU-Umweltminister haben sich auf eine Position für die Industrieemissionsrichtlinie geeinigt. Deren Anwendungsbereich soll deutlich eingeschränkt werden. Ein Zugeständnis an die Branche.
Tocilizumab for Neuromyelitis Optica Spectrum Disorder
Authors: Hao Qiukui , Grobelna Aleksandra
Published: March 2023

Patients with neuromyelitis optica spectrum disorder treated with tocilizumab may experience decreased risks of relapse or disability progression compared to before treatment, but it is uncertain whether these changes can be entirely attributed to tocilizumab (TCZ) treatment.

TCZ might be better than azathioprine for patients with neuromyelitis optica spectrum disorder in reducing relapse risk.

TCZ might improve or have no impact on pain and fatigue measures for patients with neuromyelitis optica spectrum disorder.

Adverse events were common during TCZ treatment, but patients treated with TCZ may experience adverse events at a similar or lower rate to those treated with azathioprine.

One evidence-based guideline suggests that TCZ can be used as 1 of the second-line drugs to prevent long-term relapse for patients with neuromyelitis optica spectrum disorder who have no response to other immunosuppressants.

We did not find any studies that compared TCZ to other immunosuppressants or any studies on the cost-effectiveness of TCZ for treating neuromyelitis optica spectrum disorder that met the inclusion criteria for this report.
Development of the morphodynamics on Little Ice Age lateral moraines in 10 glacier forefields of the Eastern Alps since the 1950s
Authors: Betz-Nutz Sarah , Heckmann Tobias , Haas Florian , Becht Michael
Published: March 2023

Abstract. Since the end of the Little Ice Age (LIA) in the middle of the 19th century, Alpine glaciers have been subject to severe recession that is
enhanced by the recent global warming. The melting glaciers expose large
areas with loose sediments in the form of lateral moraines, amongst other forms. Due to their instability and high slope angle, the lateral moraines are reworked by geomorphological processes such as debris flows, slides, or fluvial erosion. In this study, the development of the morphodynamics and changes in geomorphological processes on lateral moraines were observed over decades, based on a selection of 10 glacier forefields in the Eastern Alps. To identify geomorphological changes over time, several datasets of archival aerial images reaching back to the 1950s were utilized in order to generate digital elevation models (DEMs) and DEMs of difference. The aerial images were complemented by recent drone images for selected moraine sections, enabling a high-resolution analysis of the processes currently occurring. The results concerning the development of morphodynamics on lateral moraine sections are diverse: some slopes display a stagnation of the erosion rates, whereas the rates of one section
increase significantly; however, the majority of the slopes show a decline in morphodynamics over decades but stay on a high level in many cases. In particular, moraine sections with high morphodynamics at the beginning of the observation period mostly show high erosion rates up until present-day measurements, with values up to 11 cm yr−1. These moraine sections also feature heavy gullying on their upper slopes. A correlation between the development of morphodynamics and the time since deglaciation could scarcely be established. In fact, the results instead indicate that characteristics of the lateral moraines such as the initial slope angle at the time of deglaciation have a significant influence on the later morphodynamics. These observations raise concerns as to whether the until now often conducted
analyses based on the comparison of lateral moraine sections with different distances to the glacier terminus, assumed to represent varying time spans since deglaciation, can provide sound evidence concerning the process of
stabilization.
Brief communication: The Glacier Loss Day as indicator for extreme glacier melt in 2022
Authors: Voordendag Annelies , Prinz Rainer , Schuster Lilian , Kaser Georg
Published: March 2023

Abstract. In the hydrological year 2021/22 Alpine glaciers showed unprecedented mass loss. On Hintereisferner (Ötztal Alps, Austria), the glacier-wide mass balance was −3319 kg m−2. Near-daily observations of surface elevation changes from a permanent terrestrial laser scanning setup allowed determining the day when the mass balance of Hintereisferner started to become negative. This Glacier Loss Day (GLD) was already reached on 24 June in 2022 and gave way to a long ice ablation period. In 2021/22, this and the high cumulative positive degree days explain the record mass loss. By comparing the GLDs of 2019/20–2021/22, we found a gross yet expressive indicator of the glacier’s imbalance with the persistently warming climate.
Mathematical modelling of quality assessment of cooked sausages with the addition of vegetable additives
Authors: Mushtruk Mikhailo , Palamarchuk Igor , Palamarchuk Vladyslav , Gudzenko Maxim , Slobodyanyuk Nataliia , Zhuravel Dmitry , Petrychenko Ievgenii , Pylypchuk Оksana
Published: March 2023

We have studied the physicochemical composition and functional and technological properties of plant additives – wheat fibre with pumpkin pectin (WFwPP). It was found that introducing the fibre in the recipe of cooked sausages instead of fatty pork in an amount of up to 5% improves their digestibility "in vitro", increasing the relative nutritional value compared to the control sample made entirely of raw meat. Systematization is carried out, and linear, flat, and spatial estimation models in the form of a radial scheme, polygon, and polyhedron are developed. The method of mathematical modelling according to the optimization criteria for the content of essential amino acids developed the recipe composition of cooked sausage with wheat fibre and pumpkin pectin with the optimal proportion of main ingredients: beef grade I – 30%, fatty pork – 50%, WFwPP – 5%, water. The organoleptic properties of freshly cooked sausage with a vegetable ingredient were better than the control sample. The basis of the mathematical model for assessing the quality of the developed cooked sausage with wheat fibre and pumpkin pectin was chosen flat model of the polygon, taking into account the time of preservation of product quality, which was assessed as a result of regression analysis. The quality assessment results of the developed products using a computer program for calculating the area of quality profiles with subsequent graphical visualization are consistent with the organoleptic studies, which confirms the reliability of the results and the adequacy of the developed mathematical model.
Development of public-private partnership in the penal system
Authors: Skiba A. P. , Rodionov A. V. , Voronin M. Yu.
Published: March 2023

The subject. The production sector of the Russian penitentiary system requires development and modernization in order to increase the level of convicts’ employment, to ensure the growth of their labor productivity, which is ultimately aimed at increasing the level of correctional impact of socially useful labour. In modern conditions of market economy development, low efficiency of state production organizations economic activity on competitive markets, as well as the lack of budget funds for the modernization of production assets, the most promising form of organization of penitentiary institutions production activities is public-private partnership. The aim of the article is to develop scientifically based provisions that define the most promising areas for the development of Russian legislation, which will significantly improve the practice of implementing public-private partnership projects in the production sector of the penitentiary system. The methodology. In the course of the study, a complex of general scientific and special methods of scientific search was used, including scientific abstraction, a systematic approach, a dialectical method of cognition, as well as comparative legal and structural-system methods of research. The information base of the study is represented by scientific works of Russian and foreign scientists-penitentiaries, statistical data, regulations, as well as data on legal practice in the field under study. The main results, scope of application. The prerequisites for promising changes in the legislation that determine the need for a significant modernization of the production sector of the penitentiary system are identified. The expansion of the practice of implementing production projects with the involvement of private business initiatives in penitentiary institutions makes it possible to strengthen the corrective impact of socially useful labour, to improve convicts’ food and clothing provision, as well as the communal living conditions of their detention. Conclusion. The article substantiates the need to develop a concept of interaction between the penitentiary system and the business community in order to improve the efficiency of convicts’ employment and their correction, within the framework of which the most relevant directions and stages of the development of public-private partnership should be determined in the future.
The presumption of innocence as a constitutional phenomenon
Authors: Shupitskaya A. N.
Published: March 2023

Report. The presumption of innocence is a legal phenomenon that constantly attracts the attention of researchers. It is considered in legal science from the point of view of its origin, legal formalization, content and meaning. The interest in this problem is caused, on the one hand, by the multidimensional nature of this presumption, and, on the other, by its practical significance not only for society and the state, but, first of all, for a specific individual. The presumption of innocence is usually considered by specialists in the field of criminal law and criminal procedure, since, in their opinion, it belongs to the criminal sphere, the sphere of judicial proceedings, evidence. Meanwhile, such a view of the problem, it seems, limits the true essence of the phenomenon and reduces its significance.

The purpose of this study is to substantiate the constitutional nature of the principle of the presumption of innocence.

Research methodology. In this work, general scientific and private scientific research methods were used, such as analysis, synthesis, abstraction, and the case method.

The results of the conducted research. As a result of the analysis, the author comes to the conclusion that the presumption of innocence is a constitutional principle. The constitutional nature of this phenomenon is inherent in its nature, sources, content, meaning. Conclusions. The presumption of innocence is a constitutional principle. Considering it exclusively through the prism of criminal law and criminal procedure, as an element of judicial proceedings related to the theory of evidence and the adversarial nature of the parties, greatly limits its role and significance, leads to too narrow an understanding of its content. The presumption of innocence is a legal phenomenon that affects various social relations, including those related to the electoral process, to administrative proceedings, to tax relations, etc. As a constitutional principle, the presumption of innocence interacts with other constitutional principles: the principle of the rule of law, the social state, the democratic state, freedom, equality, justice, legality, etc. The presumption of innocence expresses the balance of the public and private interests of a state-organized society. The existence of this one of the most important constitutional phenomenon shows the value of the individual in the legal system.
The mediating role of the perceived value on the relationships between customer satisfaction, customer loyalty and e-marketing
Authors: Alkufahy Amer Muflih , Al-Alshare Fathi , Qawasmeh Farid Mohammad , Aljawarneh Nader Mohammad , Almaslmani Rafat
Published: March 2023

The online markets have been growing during the last near years, and many businesses have generated customer satisfaction and loyalty by developing their marketing activities. The main aim of this study is to review the related body of the literature to develop a thorough conceptual research framework including e-marketing in order to determine the respective antecedent factors of customer satisfaction and loyalty. Another study aim is examining the mediating role of the perceived value on the interrelationships between e-marketing, customer satisfaction and loyalty. Through a questionnaire survey, the study collected the data from various online shoppers in Jordan with about 482 participants. The study results indicated that e-marketing had a significant effect on customer satisfaction but did not generate customer loyalty, and the customer satisfaction had a significant effect on customer loyalty. Another key result is the perceived value mediated the relations between e-marketing and both customer satisfaction and customer loyalty. The study's respective implications offer new insights in marketing literature and conclude that the successful marketing activities should focus on the perceived value that is felt by the customers.
The impact of electronic banking services on the use of technology by customers of conventional and Islamic banks in Jordan
Authors: Hailat Khaled Qassem , Jarah Baker Akram Falah , Al-Jarrah Mefleh Faisal Mefleh , Almatarneh Zeyad
Published: March 2023

The aim of this study was to examine and determine the impact of electronic banking services on the use of technology by customers of conventional and Islamic banks in Jordan. For the current study, a random sample of 580 customers in Jordanian conventional and Islamic banks was selected using the quantitative research methodology, and in order to gather the necessary data, the study employed a survey questionnaire instrument that was developed based on the earlier relevant literature and studies. The results of this study showed that perceived ease of use (PEU), perceived utility (PU), simplicity of use (SU), and social influence (SI) all significantly affected the use of technology in Jordanian conventional and Islamic banks.
The effects of digital transformation, digital leadership, and entrepreneurial motivation on business decision making and business process performance: Evidence from greater Amman municipality
Authors: Hanandeh Ahmad , Altaher Asmahan Majed , Halim Mona , Rezk Walaa , Mahfoudh Naoufel , Hammouri Qais , Darawsheh Saddam Rateb
Published: March 2023

The purpose of this research was to examine the effects of digital transformation, digital leadership, and entrepreneurial motivation on business decision making and business process performance in the Greater Amman Municipality. The study's hypotheses were put to the test and proven through a variety of quantitative analysis and data processing techniques. The research hypotheses were evaluated using a Structural Equation Model. Participants in this research are managers from the middle and high echelons of the Greater Amman Municipality, who were responsible for making decisions in their respective divisions. One hundred and eighty middle and upper-level managers with at least eight years' experience in public service were recruited for this study from the Greater Amman Municipality. Distributed questionnaires and the deliberate sampling technique were used to compile this data. Decision making had a positive effect on the business process performance, and the results of hypothesis testing data processing using Structural Equation Model indicated that digital transformation, digital leadership, and the motivation of the business environment all had positive and significant effects on business decision making and business process performance in the Greater Amman Municipality. To conduct their research, the authors opted to focus on digital transformation, which includes four primary components: process transformation, business model change, domain transformation, and cultural transformation. The following dimensions commander, communicator, collaborator, and co-creator were all indicative of digital leadership. Entrepreneurial motivation could be seen in the word’s communication, hassle-free work environment, mastering the art of constructive criticism, and trust among others. The novel aspect of this study is the model developed to explain the interplay between digital transformation, digital leadership, and entrepreneurial motivation, and how these factors influence business decision making and business process performance at Greater Amman Municipality.
Weak and renormalized solutions for anisotropic Neumann problems with degenerate coercivity
Authors: Benboubker Mohamed Badr , Benkhalou Hayat , Hjiaj Hassane
Published: March 2023

In this work, we study the following quasilinear Neumann boundary-value problem$$\left\{\begin{array}{ll}\displaystyle -\sum^{N}_{i=1} D^{i}(a_{i}(x,u,\nabla u))+|u|^{p_{0}-2} u= f(x,u,\nabla u) & \mbox{in } \ \quad \Omega,\\\displaystyle \sum^{N}_{i=1} a_{i}(x,u,\nabla u)\cdot n_{i} = g(x) & \mbox{on } \ \quad \partial\Omega,\end{array}\right.$$where $\Omega$ is a bounded open domain in $\>I\!\!R^{N}$, $(N\geq 2)$. We prove the existence of a weak solution for $f \in L^{\infty}(\Omega)$ and $g\in L^{\infty}(\partial\Omega)$ and the existence of renormalized solutions for $L^{1}$-data $f$ and $g$. The functional setting involves anisotropic Sobolev spaces with constants exponents.
Biochemical Evaluation of Antioxidant properties of A Zn-Avicularin Complex Studied in High Fat Diet Fed- Low Dose Streptozotocin Induced Experimental Type 2 Diabetes in Rats
Authors: Parvathi Neeli , Pillai Subramanian Iyyam , Pillai Subramanian Sorimuthu
Published: March 2023

Zinc is an essential trace element next to iron in the human system. Its central role in the synthesis, storage, and functional aspects of insulin is well established. Ever since the insulin-mimetic activity of zinc was recognized, several zinc complexes have been synthesized and studied for their antidiabetic and other pharmacological properties. However, its clinical application is narrow due to poor absorption, toxicity associated with prolonged use. Hence, endeavors are being made for the advancement of zinc complexes with various organic ligands of known therapeutic values to avert the toxicity of zinc. Avicularin, a bioactive flavonol originally isolated from the leaves of Polygonum aviculare Linn., is a quercetin derivative in which the α-L-arabinofuranosyl residue is linked at position 3 of quercetin via a glycosidic linkage. It is non-toxic and reported to possess a wide range of pharmacological properties. Though Avicularin is a glycoside of quercetin, it is hydrophilic while quercetin is lipophilic and hence they may differ in absorption rate. In view of the beneficial and pharmacological properties bestowed with Avicularin, recently we have reported the synthesis, spectral characterization and evaluation of antidiabetic properties of a new Zn-Avicularin complex in HFD fed low dose STZ induced experimental type 2 diabetes in rats. In the present study, an attempt has been made to evaluate the antioxidant properties of the Zn-Avicularin complex by analyzing the levels of oxidative stress markers such as lipid peroxides, hydroperoxides and protein carbonyls in the plasma, pancreas, hepatic and renal tissues. The status of enzymatic antioxidants such as SOD, catalase, Glutathione peroxidase as well as non-enzymatic antioxidants such as vitamin C, vitamin E and ceruloplasmin were assayed. Oral administration of the Zn-Avicularin complex at a concentration of 5mg/kg b.w/rat/day for 30 days significantly ameliorates the hyperglycemia-induced oxidative stress in the diabetic groups of rats and the efficacy was comparable with metformin.
Cytotoxicity Evaluation of Erythrina lithosperma Miq. Leaf Extract against Vero Cell Lines: In Vitro Study
Authors: Widiastuti Ni Komang , Virginia Ni Made , Fery Yastawan I Made , Ayu Putri Permatasari Anak Agung , Wiradana Putu Angga , Widhiantara I Gede , Hari Sucipto Teguh
Published: March 2023

In several societies, the development of traditional medicine employing plants to enhance medicinal formulations has been promoted as a valuable offering in therapeutic applications. Bali Province in Indonesia, which has a healthy culture until now, has a rich history of traditional medicine regarding the utilization of local plants. The purpose of this study was to determine the cytotoxicity of Erythrina lithosperma Miq leaf extract (ELLE) on Vero cells to gain knowledge of its potential as a standardized traditional medicine. A cytotoxicity test was performed on Vero cell lines grown on M119 medium with 10% FBS and incubated at 37°C in a CO2 incubator until confluent. Cells were collected and grown in 96 well microplates at a cell density of 2x104 cells/100mL/well at the start. After a 24-hour incubation period, extracts were subjected to concentrations ranging from 31.25 to 10,000µg/ml. Cell viability was determined using the MTT technique (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide). A one-way ANOVA test with a significance level of 5% was performed. Cell viability increased with decreasing concentration extracts used. There was no significant difference between concentrations of 500, 250, 125, 63, and 31µg/ml. A consistent and significant reduction occurred in cell proliferation added with very high extract concentrations. Empirically ELLE can be used as a traditional medicine for certain diseases, this experiment reduces the viability of Vero cells lines at very high concentrations. Overall, the findings of this study suggest that the investigated ELLE might be developed as a novel dietary component and traditional medicinal preparation for promoting human health.
Neem leaf extract as a Potential antibiofilm and anti ESBLS agent for K. pneumoniae
Authors: Abdulhameed Jassim Sawsan , Hamid Hassan Muthanna
Published: March 2023

K. pneumoniae is well known for its ability to form biofilm on indwelling medical devices. These biofilms are difficult to remove because of their high tolerance to conventional antibiotics. Therefore, there is a need to look for alternative agents such as medicinal plants, which can eradicate or inhibit biofilm effectively. This study evaluated the role of neem in inhibiting ESPLs production and biofilm formation by K. pneumoniae. Factors contributing to adherence and biofilm formation were also studied. Results demonstrated that neem leaves extract was quite effective in disrupting formation of biofilms and ESBLS activity at P- value: . Moreover, the level of exopolysaccharide, which contributes to biofilm formation, was also affected significantly. Results confirm the effectiveness of neem extract in inhibiting biofilm formation. Such studies can lead to the discovery of safe antimicrobial drugs from natural sources without the risk of resistance".
Validation of Liquid Chromatographic Analytical Method for Determination of Aspirin, Caffeine and Paracetamol in some Pharmaceutical Tablets Form in Iraqi market
Authors: Mahdi Saeed Ahmed , Jasim Mohammed Omer , Ghaaeb Hussein Nada
Published: March 2023

In this research, an accurate, efficient and reproducible isocratic reversed-phase high-performance liquid chromatographic (RP-HPLC) method has been developed and validated for the determination of aspirin (ASP), caffeine (CAF), and Paracetamol (PCM). A mixture of drugs as standard material and in formulation tablets were separated using an phenomenex C18 column, (L, 15cm, I.D, 0.46cm, and Size of particle, 5μm), with the shimadzu RP – HPLC, model LC–20 - A, Japan. The eluent phase was optimized through the design, experiment. Elution was done by an eluent phase composed of water (H2O), methanol (MOH) and acetonitrile (ACN) mixture have a ratio of (60: 20: 20, V/V), with adjusted pH of 4.0 with acetic acid, have a pumped flow rate of 0.5mL/min. The drugs, separation were performed at 254nm using a UV-VIS - detector for 8 min. The time of elution for the drugs was recorded at (3.980, 4.366, and 6.894 min) for PCM, CAF and ASP respectively. The validation of the method was conducted in a range of concentration (1 - 100μg/mL) for PCM, CAF and ASP. The method was found to be robust, specified and resisting against the small experimental changes in the value of the flow rate, pH, and wavelength. The LOD were found to be 0.01μg/mL, 0.03μg/mL and 0.05μg/mL for PCM, CAF and ASP respectively. The values of LOQ were 0.033μg/mL, 0.099μg/mL and 0.165μg/mL for PCM, CAF and ASP respectively.
Knowledge, Attitudes and practices to detect and prevent Chronic Kidney Disease among hypertensive patients at primary and cardiology clinics in the Emirates of Ajman and Sharjah, UAE
Authors: A. Orabi Ansam , A. Hassan Nageeb , J. Shahwan Moayad , M. Qazi Ali
Published: March 2023

The alarming association of Hypertension and Chronic Kidney Disease (CKD) has urged severalresearch to investigate the level of knowledge, attitudes and practices (KAP) of CKD among hypertensive patients,yet none was donein the United Arab Emirates (UAE). This study aimed to assess the KAP concerning CKDand their relation to the socio-demographic and clinical factors of hypertensive patients. A cross-sectional study was conducted among hypertensive patients attending cardiology and primary clinics in the Emirates of Ajman and Sharjah in the UAE. A validated face-to-face questionnairewas conductedfrom December 2019 until February 2020. The questionnaire consisted of three sections: socio-demographic characteristics, clinical characteristics and the KAP scales. Multiple linear regression was used to analyze the relation of the KAP scores to the sociodemographic and clinical characteristics.A total of 200 patients with hypertension consented to participate. The mean age was 49.97(±9.67) years. The percentages of knowledge, attitudes and practices scores about prevention and detection of CKD were 50.8%, 66.6% and 71.7% respectively.A higherknowledge score wasrelated significantly to female gender, urban residency and university level education.Cardiology clinic setting was the only significant factor related to higher attitudes score. Furthermore, higher knowledge score, higher attitudesscoreand urban residencywas significantly related tohigher practices score.Hypertensive patients require more attentionto implement CKD awareness programs that could possibly improve theirpreventive practices.
The Analysis of MMP-13 Expression on Hydroxyapatite Tooth Graft Application Compared to Hydroxyapatite Xenograft
Authors: Perdana Sonny , Prahasanti Chiquita , Bargowo Lambang , Prasetyo Sista , Riawan Wibi
Published: March 2023

Background: Bone graft materials are widely used to support the success of periodontal tissue treatments. Graft material has been used extensively however it has some deficiencies such as limited availability, high levels of resorption, immunological reactions and the risk of contamination as well as high costs. Therefore recent research is needed to explore potential usage of the tooth graft. Objective(s): The objective of this research is to comparing the MMP-13 expression in bone healing after grafting the incisor’s extraction sockets with hydroxyapatite tooth graft and hydroxyapatite xenograft. Research Methods: 33 adult male Cavia cobayas were divided into three groups: hydroxyapatite xenograft, hydroxyapatite tooth graft, and control (without treatment). Bone tissue sections were stained with diaminobenzidine and then dripping with anti-MMP-13 monoclonal antibody. The number of MMP-13 expression by osteoblast cells was carried out quantitatively based on the colourintensity in each group under the OLYMPUS microscope with 400x magnification. Results: The value of MMP-13 expression was higher on the tooth graft and xenograft group than the control group. The ability of osteoconduction of hydroxyapatite derived from porous hydroxyapatite structure will facilitate angiogenesis so that osteogenic cells can migrate and attach to the graft to induce the new bone growth. The tooth graft group had higher MMP-13 value than xenograft group. High solubility of graft material could affect bone remodeling and mineralization processes because of the presence of inflammatory cells is detrimental to the healing process. Conclusion: As a new graft material, tooth graft has a capability to induce osteoconductive and osteoinductive that similar with the xenograft.
Synthesis, Spectroscopic Study of new Substituted heterocyclic compounds derived from Molononitrile and Cytotoxic agents against MCF-7 Human Cancer Cells
Authors: Faleh Mohsein Hanan , Nsaif Jasim Faten
Published: March 2023

In the present work , 4-((dicyanomethyl)diazenyl)-N-(5-methylisoxazol-3-yl)benzene sulfonamide E and 2,2'-(1E,1E')-(sulfonylbis(4,1-phenylene))bis(diazene-2,1-diyl) dimalononitrile C were synthesized from the reaction of Sulfamethaxazole and Dapsone with Malononitrile and condensed with 2,4dinitophenyl hydrazine derivatives to produce 3,5diaminopyrazole derivatives E1 and C1.condensation with hydroxyl amine hydrochloride produce isoxazole derivative E2,C2 .Treatment of E and C with urea and thiourea yielded the pyrimidine derivatives E3-E4,C3-C4 and treatment with secondary amine afforded piperazine derivatives E5,C5. While its condensation with thiosemicarbazide yielded the derivatives E6, C6. The structure of the newly synthesized compound were established on the basis of physical data and spectral methods such as IR, 1H-NMR ,13C-NMR and Mass spectra. Cytotoic evaluation of four compounds, against MCF-7 (human breast adeno carcinoma) cell lines.
DIGITAL ECONOMY AND DIGITAL TRANSFORMATION IN KAZAKHSTAN
Authors: Buganova A. A. , Umirzakov S. Y. , Nurpeisova A. A.
Published: March 2023

The purpose of the study is to defi ne the terms of «digitization», «digitalization», «digital strategy», «digital transformation» and «digital economy», as well as to analyze the state of the digital economy based on international indices.Methodology – in the course of the study, methods of logical generalization, systematization and grouping of information, as well as critical analysis are used.Originality / value of the study – the results of the study will help in adjusting the strategy of the Republic of Kazakhstan when creating a new program on the digitalization of Kazakhstan and identify priority areas, taking into account the advantages and weaknesses of the country.Findings – the basic concepts of the digital economy are considered, digital transformation models and approaches are analyzed, the main indices of world ratings for assessing the digital economy of Kazakhstan and readiness for digital transformation are given, a SWOT-analysis of digital transformation in the Republic of Kazakhstan was performed.
EMIGRATION FROM KAZAKHSTAN: FOCUS ON NORTHERN REGIONS AND RURAL AREAS
Authors: Urazova B. A. , Kurmanova G. K. , Sukhanberdina B. B.
Published: March 2023

The purpose of the research is to discuss emigration from Kazakhstan. Since 2014, the outfl ow of the population from the country continues both from cities and from rural areas.Methodology. When writing the article, methods of scientifi c knowledge, theoretical generalization, comparative analysis of the current and past states were used based on data from the Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan.Originality / value of the research. Based on the available data, the authors made an attempt to analyze the eff ectiveness of the implementation of the state programs «With a diploma – to the village» and «Enbek», aimed at solving the problems of the outfl ow of the population from the northern regions of Kazakhstan and rural areas.Findings. The greatest outfl ow of the population is typical for the regions located in the central, northern and eastern parts of Kazakhstan (all these regions are combined into one group «northern regions»). The fact that people of working age are leaving the country is a matter of concern. To compensate for the losses of the population, the state implements various programs: «With a diploma – to the village» and «Enbek».The state program «With a Diploma – to the Village» is aimed at attracting graduates of higher educational institutions to live in rural areas and replenish the labor force. The state program «Enbek» aims to stimulate voluntary relocation to the northern regions from the labor surplus (southern) regions to the northern regions of Kazakhstan. The implementation of these programs has not been able to address the problem of the outfl ow of the population both from the northern regions of Kazakhstan and from rural areas. In our opinion, these programs require revision considering the conditions on the ground.
ASSESSMENT OF THE EURASIAN ECONOMIC UNION SCIENTIFIC-TECHNOLOGICAL INTEGRATION CAPACITY: STRATEGIC PRIORITIES AND DEVELOPMENT DIRECTIONS
Authors: Satpayeva Z. T. , Alzhanova F. G. , Smagulova A. S.
Published: March 2023

Purpose of the research – assessment of Eurasian Economic Union (EAEU) institutional scientifi ctechnological integration capacity by identifying and comparing strategic priorities and directions of scientifi ctechnological development of the member-countries.Methodology. The study was conducted on the basis of an institutional approach. The main research methods included comparison, quantitative and qualitative content analysis of strategic documents on scientifi ctechnological development of the member-countries. The respective strategies of Russia, Belarus, Kazakhstan,Kyrgyzstan and Armenia served as input data. The Voyant tools software was used for text processing.Originality / value of the research. The EAEU member-countries' national economies have been actively integrating in the post-Soviet space, however the issues of scientifi c-technological integration are not suffi ciently considered. This study is aimed to fi ll this study gap. The study results can serve as substantiation for key directions of developing scenarios, recommendations and mechanisms to improve the effi ciency of scientifi c-technological integration in order to form a single scientifi c-technological space in the EAEU.Findings. It was revealed that scientifi c-technological cooperation was an independent vector of EAEU integration, directions in the fi eld of scientifi c-technological development, which opens up opportunities for active scientifi c-technological cooperation. The institutional capacity of EAEU scientifi c and technological integration is quite high.
CONCEPTUAL FOUNDATIONS AND POSSIBILITIES OF DIGITALIZATION OF MEDICAL SERVICES
Authors: Orazgaliyeva E. B. , Smykova M. R.
Published: March 2023

The article examines the conceptual foundations of the development of digital medicine and studies the possibilities of using digital technologies for the implementation of medical services. Purpose of the research is to reveal the concepts, identify the stages, directions of digitalization in medicine and research the directions of application of digital medical technologies.Methodology of the research is the analysis of secondary information, theoretical sources, the method of grouping and ranking, marketing research using the method of morphological analysis in the form of expert evaluation.Originality/value of the research: the tools of digital medicine are structured and systematized, the most eff ective ways of their application for solving signifi cant problems in the fi eld of medicine are determined, taking into account the research of the theoretical base and the opinions of experts.Findings of the study: the stages of digitalization are systematized, the features of the use of digital technologies in medicine are researched. The main directions of digitalization of medical services are structured and defi ned. The author's contribution lies in the fact that on the basis of the conducted research in the form of morphological analysis, the purpose and possibilities of applying certain areas of digitalization in medicine are more accurately and correctly formulated.