bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibody profiles in COVID‐19 convalescent plasma prepared with amotosalen/UVA pathogen reduction treatment
Authors: Bagri Anil , de Assis Rafael R. , Tsai Cheng‐Ting , Simmons Graham , Mei Zhen W. , Von Goetz Melissa , Gatmaitan Michelle , Stone Mars , Di Germanio Clara , Martinelli Rachel , Darst Orsolya , Rioveros Jowin , Robinson Peter V. , Ward Dawn , Ziman Alyssa , Seftel David , Khan Saahir , Busch Michael P. , Felgner Philip L. , Corash Laurence M.
Published: February 2022

Background

COVID‐19 convalescent plasma (CCP), from donors recovered from severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) infection, is one of the limited therapeutic options currently available for the treatment of critically ill patients with COVID‐19. There is growing evidence that CCP may reduce viral loads and disease severity; and reduce mortality. However, concerns about the risk of transfusion‐transmitted infections (TTI) and other complications associated with transfusion of plasma, remain. Amotosalen/UVA pathogen reduction treatment (A/UVA‐PRT) of plasma offers a mitigation of TTI risk, and when combined with pooling has the potential to increase the diversity of the polyclonal SARS‐CoV‐2 neutralizing antibodies.

Study design and methods

This study assessed the impact of A/UVA‐PRT on SARS‐CoV‐2 antibodies in 42 CCP using multiple complimentary assays including antigen binding, neutralizing, and epitope microarrays. Other mediators of CCP efficacy were also assessed.

Results

A/UVA‐PRT did not negatively impact antibodies to SARS‐CoV‐2 and other viral epitopes, had no impact on neutralizing activity or other potential mediators of CCP efficacy. Finally, immune cross‐reactivity with other coronavirus antigens was observed raising the potential for neutralizing activity against other emergent coronaviruses.

Conclusion

The findings of this study support the selection of effective CCP combined with the use of A/UVA‐PRT in the production of CCP for patients with COVID‐19.
Acute kidney injury manifesting as renal tubular acidosis with proximal and distal renal tubular dysfunction in a dog with acute pancreatitis
Authors: Barton James C. , Mäntylä Noble Peter‐John , O'Connell Erin M.
Published: February 2022

Objective

To describe the clinical presentation and management of a critically ill dog with profound renal tubular acidosis (RTA) with proximal and distal renal tubular dysfunction.

Case Summary

A 3‐year‐old neutered female Border Terrier was presented with frequent regurgitation resulting from acute pancreatitis with severe ileus. Venous acid–base analysis and complete urinalysis confirmed the presence of normal anion gap metabolic acidosis with inappropriately alkaline urine (pH 8), consistent with distal RTA. Urinalysis, urine amino acids, and urinary fractional excretion of electrolytes revealed glycosuria (with normoglycemia), aminoaciduria, and increased fractional excretion of sodium, calcium, and phosphate consistent with generalized proximal renal tubulopathy or Fanconi syndrome. The dog responded well to supportive care and alkaline therapy and made a complete recovery.

New or Unique Information Provided

To the authors’ knowledge, this is the first description of RTA with proximal and distal renal tubular dysfunction in the veterinary literature. Furthermore, the authors hypothesize that the transient RTA was a manifestation of acute kidney injury secondary to acute pancreatitis, the first report of this in the literature.
Experimental Study on the Influence of Solar Heat Gain on the Thermal Performance of Hollow Ventilated Interior Wall
Authors: Zhou Jiri , Yu Tao , Lei Bo
Published: February 2022

The heating system combining solar air collector with hollow ventilated interior wall (SAC-HVIW) can effectively extend the heating time. However, due to the large wall-window ratio of buildings on Tibetan Plateau, the strong solar radiation irradiating on the interior wall may influence the thermal performance of HVIW. In this paper, an experimental room is constructed to study the influence of external solar heat gain on the thermal performance of HVIW. Steady-state measurements are carried out by considering different ventilation rates, supply air temperatures and heat gains. Results show that the external heat gain has almost no effect on U-value, but it increases the heating capacity by increasing the logarithmic mean temperature difference (LMTD). For all cases, the heating capacity of HVIW is related to LMTD and supply air velocity, and U-value mainly increases with supply air velocity. Heat transfer of the interior surface of HVIW is dominated by forced convection which increases linearly with supply air velocity. The radiant heat transfer coefficient of the exterior surface of HVIW is not affected by the external heat gain with the mean value of 5.65 W/(m2 · K), while the convective heat transfer coefficient increases logarithmically with the external heat gain. The proportion of radiant heat transfer decreases as a power function with the increase of the exterior surface temperature. Measurements in this paper are used to evaluate the influence of external heat gain on the heating performance of HVIW, which is beneficial to the design of HVIW.
High-energy photoelectron spectroscopy of Si(100) with Cr Kα excitation
Authors: Deleuze Pierre-Marie , Artyushkova Kateryna , Martinez Eugénie , Renault Olivier
Published: February 2022

Si (100) wafer was analyzed by high-energy photoelectron spectroscopy (HAXPES) using monochromatic Cr Kα radiation (5414.8 eV). The HAXPES spectra reported here include a survey scan and high-resolution spectra of Si 1s, Si 2s, and Si 2p core-levels.
High-Resolution Dynamics of Hemodilution After Exercise-Related Hemoconcentration
Authors: Komka Zsolt , Szilágyi Brigitta , Molnár Dóra , Sipos Bence , Tóth Miklós , Elek János , Szász Máté
Published: February 2022

Purpose: Hemoconcentration during acute intense exercise is intensively investigated, while the rearrangement of hematological parameters during the recovery period is less understood. The aim of our study was to understand the mechanisms of hemodilution after short-term dynamic exercise. Methods: Twelve euhydrated male kayak athletes and 6 untrained controls were examined on a spiroergometer. In addition to the continuous recording of circulatory parameters, blood samples were taken at rest, at maximum load, and during restitution with a dense sampling frequency. Hemoglobin, hematocrit, osmolality, blood components, and core temperature were measured. Results: The hemoconcentration, independently of training status, reached its maximum (athletes Δ9.59% [4.18%] vs controls Δ11.85% [2.71%]) in the first minute of the recovery period. There was a significant increase in core temperature, reducing the viscosity of blood and promoting tissue oxygenation. High cardiac output and the increased blood flow compensate for viscosity being elevated by hemoconcentration during exercise. Hemoconcentration was maintained for 7 to 10 minutes and then diluted back to baseline 30 minutes after exercise. Temporarily higher viscosity during reduced cardiac output may result in a critical hemoconcentration zone, elevating the risk of circulatory overload. Elite athletes have a faster cardiac output decrease compared with that of hemodilution, making the circulation more vulnerable. We supposed that hemodilution was guided independently by plasma- and erythrocyte-related effectors. Conclusions: After high-intensity dynamic acute exercise, hemodilution is driven by independent factors, and a critical hemoconcentration zone may be formed during the recovery period in trained elite athletes.
Do Race Results in Youth Competitions Predict Future Success as a Road Cyclist? A Retrospective Study in the Italian Cycling Federation
Authors: Gallo Gabriele , Mostaert Mireille , Faelli Emanuela , Ruggeri Piero , Delbarba Sundeep , Codella Roberto , Vansteenkiste Pieter , Filipas Luca
Published: February 2022

Purpose: The aim of this study was to investigate the relationship between youth road cycling success and becoming a professional cyclist. Specifically, the authors sought to analyze (1) the differences in the success scores in youth categories between future professional (PRO) and future nonprofessional (NON-PRO) cyclists, (2) whether relative age effect influences youth road cycling career pathways, and (3) whether youth competition success could predict a future career as a professional cyclist. Methods: The number of points gathered in the annual national ranking of 1345 Italian cyclists in the U17, U19, and U23 categories were retrospectively analyzed. Participants were divided into 2 groups: PRO (n = 43) and future NON-PRO (n = 1302), depending on whether they reached the professional level. Results: PRO outperformed NON-PRO in all the youth categories considered (ie, U17, U19, and U23). Older cyclists within the same annual age group were not overrepresented in PRO and do not have an advantage over younger cyclists within all the competition years. The number of points gathered in youth competitions provides an indication of probability of becoming professional cyclists from U17 onward with the predictive value increasing with age category. Conclusions: Handling the transition to a new age group well (especially the U19–U23 transition), and therefore having success competing against older and more experienced cyclists, is an important factor for talent identification in youth cycling.
Case Study: A Jaw-Protruding Dental Splint Improves Running Physiology and Kinematics
Authors: Cardoso Filipa , Coelho Eduardo P. , Gay Ana , Vilas-Boas João Paulo , Pinho João C. , Pyne David B. , Fernandes Ricardo J.
Published: February 2022

Wearing an intraoral jaw-protruding splint could enhance respiratory function in clinical settings and eventually exercise performance. Purpose: The authors studied the acute effect of wearing a lower-jaw-forwarding splint at different protruding percentages (30% and 50%) across a wide range of running exercise intensities. Methods: A case study was undertaken with a highly trained and experienced 27-year-old female triathlete. She performed the same incremental intermittent treadmill running protocol on 3 occasions wearing 3 different intraoral devices (30% and 50% maximum range and a control device) to assess running physiological and kinematic variables. Results: Both the 30% and 50% protruding splints decreased oxygen uptake and carbon dioxide production (by 4%–12% and 1%–10%, respectively) and increased ventilation and respiratory frequency (by 7%–12% and 5%–16%, respectively) along the studied running intensities. Exercise energy expenditure (approximately 1%–14%) and cost (7.8, 7.4, and 8.0 J·kg−1·m−1 for 30%, 50%, and placebo devices, respectively) were also decreased when using the jaw-protruding splints. The triathlete’s lower limbs’ running pattern changed by wearing the forwarding splints, decreasing the contact time and stride length by approximately 4% and increasing the stride rate by approximately 4%. Conclusions: Wearing a jaw-protruding splint can have a positive biophysical effect on running-performance-related parameters.
VAMP3 and VAMP8 Regulate the Development and Functionality of Parasitophorous Vacuoles Housing Leishmania amazonensis
Authors: Séguin Olivier , Mai Linh Thuy , Acevedo Ospina Hamlet , Guay-Vincent Marie-Michèle , Whiteheart Sidney W. , Stäger Simona , Descoteaux Albert
Published: February 2022

To colonize mammalian phagocytic cells, the parasiteLeishmaniaremodels phagosomes into parasitophorous vacuoles that can be either tight-fitting individual or communal. The molecular and cellular bases underlying the biogenesis and functionality of these two types of vacuoles are poorly understood.
Supplemental Material: Subduction initiation of the western Paleo-Asian Ocean linked to global tectonic reorganization: Insights from Cambrian island-arc magmatism within the West Junggar, NW China
Authors: Zhang Yunying , Yin Jiyuan , al. et
Published: February 2022

Table S1: Zircon U-Pb dating results for the felsic and gabbroic plutons from West Junggar, NW China. Table S2: Zircon Hf-O isotope compositions for the felsic and gabbroic plutons from West Junggar, NW China. Table S3: Whole-rock major and trace element compositions for the felsic and gabbroic plutons from West Junggar, NW China. Table S4: Trace element compositions of zircons in the felsic and gabbroic plutons from West Junggar, NW China.
Supplemental Material: Detrital zircon record of the Mesoproterozoic Belt basin and implications for horizontal and vertical tectonic models
Authors: Parker Stuart , Hendrix Marc
Published: February 2022

Detailed sample data, statistics, and model parameters
Near-complete vision recovery from bilateral serous retinal detachment associated with thrombotic thrombocytopenic purpura
Authors: Nguyen Tran , Radhakrishnan Saikripa M , Radhakrishnan Srinidhi J , Johnson David H
Published: February 2022

Ocular manifestations of thrombotic thrombocytopenic purpura (TTP) are uncommon, and bilateral retinal detachment is a rare presentation of TTP. We report a rare case of bilateral retinal detachment from underlying TTP in a patient presenting with vision loss. A 56-year-old man presented with a 4-day history of bilateral vision loss. Bilateral serous retinal detachment was confirmed using dilated ophthalmoscope examination. Laboratory results were significant for severe thrombocytopenia, peripheral smear revealed numerous schistocytes and ADAMTS13 activity of less than 1%. The patient was treated with plasma exchange (PLEX), prednisone, rituximab and caplacizumab. This case report highlights that prompt treatment of TTP with PLEX, prednisone, rituximab and caplacizumab could result in significant vision recovery.
Laryngeal tuberculosis: a neglected diagnosis
Authors: Raj Reshma , Sud Parul , Saharan Neha , Virk Ramandeep Singh
Published: February 2022

A 24-year-old woman visited the Ear Nose Throat (ENT) outpatient department with complaints of hoarseness for 2 months not responding to conservative management. Laryngoscopic examination revealed a whitish ulceroproliferative lesion in the anterior commissure and anterior two-thirds of bilateral true vocal cords with surrounding necrosis. In view of the above findings, the patient was planned for biopsy under general anaesthesia. Intraoperative findings showed multiple whitish necrotic friable tissue involving anterior two-thirds of bilateral false vocal cords, ventricle, bilateral true vocal cords, both aryepiglottic folds and laryngeal surface of epiglottis. Postoperative histopathology was consistent with tuberculosis. A pulmonology consultation was taken, and the patient was started on anti-tuberculosis chemotherapy. One month post therapy, the voice was symptomatically better. A flexible fibreoptic laryngoscopic examination was done, which revealed almost complete resolution of the lesion with minimal ulceration at the anterior one-third of right true vocal cord.
Rare case of littoral cell angioma recognised on CT simulation for adjuvant radiation treatment for early stage breast cancer
Authors: Yaney Alexander , Jones Daniel , Perry Kyle A , Jhawar Sachin R
Published: February 2022

A 63-year-old woman with pathological anatomic/prognostic stage IA ER+/PR+/HER2- multifocal invasive mammary carcinoma with mixed ductal and lobular features of the left breast underwent lumpectomy with sentinel lymph node biopsy. During evaluation of the CT simulation for adjuvant radiation (RT) treatment planning, a liver lesion and splenomegaly were noted. A subsequent MRI abdomen revealed a large, indeterminate splenic lesion with a wide differential and a benign liver cyst. The patient ultimately underwent splenectomy, with pathology consistent with littoral cell angioma, a rare entity associated with several malignancies. At last follow-up, 7 months after completion of RT, she remained cancer free while on anastrazole and was doing well clinically.
Stability Analysis for Spatial Autoparametric Resonances of Framed Structures
Authors: Liu Wei , Zhang Bin , Shen Chao , Li Yu-Chun
Published: February 2022

The spatial dynamic instabilities of framed structures due to autoparametric resonances have been seldom investigated in the published literature. Based on the finite element method (FEM), the spatial parametric vibration equations are established for general framed structures. The Newmark’s method and the energy-growth exponent (EGE) are used to determine the stability of the spatial autoparametric resonances of framed structures. A portal frame model is used to conduct a spatial (out-of-plane) autoparametric resonance experiment. The numerical results of the autoparametric resonances are found to agree with those of the test, which proves the validity of the present theoretical formulation. A numerical example for autoparametric resonance stability analysis of a spatial frame is presented to firstly predict the three instability modes of autoparametric resonances, i.e. global unidirectional translational instability, bidirectional (diagonal) translational instability and torsional instability. When the excitation frequency is approximately twice the modal frequency of spatial vibration of a framed structure, spatial dynamic instability will occur due to autoparametric resonance. A small excitation force can cause a strong autoparametric resonance of the framed structure. The potential risk of spatial dynamic instability is revealed for the framed structures under periodic loads.
A Survey on Perfectly Secure Verifiable Secret-sharing
Authors: Chandramouli Anirudh , Choudhury Ashish , Patra Arpita
Published: February 2022

Verifiable Secret-Sharing(VSS) is a fundamental primitive in secure distributed computing. It is used as a building block in several distributed computing tasks, such as Byzantine agreement and secure multi-party computation. In this article, we consider VSS schemes withperfectsecurity, toleratingcomputationally unboundedadversaries. We comprehensively survey the existing perfectly secure VSS schemes in three different communication settings, namely, synchronous, asynchronous, and hybrid setting and provide full details of the existing schemes in these settings. The aim of this survey is to provide a clear knowledge and foundation to researchers who are interested in knowing and extending the state-of-the-art perfectly secure VSS schemes.
Photoelectrochemical Activity of CdS/CdSe-Deposited TiO2 photoanodes Due to Electrolytes with and without Sacrificial Reagents
Authors: Ahmed Rasin , Xu Yin , Zangari Giovanni
Published: February 2022

Literature on the photoelectrochemical (PEC) activity of TiO2 electrodes modified by CdS and or CdSe depositions are mostly performed using electrolytes with sacrificial reagents. The overall performance of a PEC system can vary significantly simply due to the use of different electrolytes, especially those with and without sacrificial reagents. In this paper, we have used a well-known TiO2 nanotube structure modified by CdS/CdSe nanoparticles deposited by successive ionic layer adsorption and reaction (SILAR) method to highlight the difference in PEC activities arising from sulfite oxidation and water oxidation. Linear Sweep Voltammograms measured under a standard AM1.5G simulated spectra, 1 sun (100 mWcm-2) exhibited a photocurrent density of 0.92 mAcm-2 at 1.23 V vs. RHE for the TiO2/CdS/CdSe photoactive electrodes using an aqueous alkaline electrolyte (1 M NaOH) for which water oxidation occurs. However, for the similar photoanode an 8-fold higher photocurrent of 7.4 mAcm-2 (at 1.23 V vs. RHE) was observed using an Na2S/Na2SO3 aqueous electrolyte where sulfite oxidation was the dominant mechanism for the enhanced photocurrent. A maximum STH efficiency of 0.71% and water splitting efficiency of 12.4% was determined for water oxidation. The STH efficiency parameter is more relevant to water splitting systems and to report such device efficiencies we propose that the ‘water splitting efficiency’ parameter is much more meaningful since it correlates the PEC activity specifically to water splitting and not to other pathways that produce an artificially enhanced photocurrent through the use of sacrificial reagents. The incident photon-to-current conversion efficiency spectrum measured at 1.23 V (vs. RHE) bias for the TiO2 photoanodes modified by CdS/CdSe nanoparticles revealed that the current conversion efficiency is lower (~17% or less) when absorption occurs solely from the external CdSe layers indicating higher recombination during charge transport. The increase of dark current observed in the linear sweep voltammetry plots for the voltage range of -0.25 V to +0.15 V vs. RHE was attributed to anodic dissolution of the photoanodes in aqueous electrolytes containing no sacrificial reagents. The photocurrents and onset potentials for the CdS/CdSe modified TiO2 photoanodes were found to improve under acidic conditions showing a slightly increased PEC activity and faster reaction kinetics.
Research on the Architecture of Digital Song and Dance Costume Design System Based on Intelligent Deep Learning Algorithm
Authors: Wang Wenli
Published: February 2022

In order to improve the intelligence and reliability of song and dance costume design, this article combines the intelligent deep learning algorithm to improve the digital costume design process. In order to solve the problem of minimizing the energy of image deformation, this paper proposes to transform it into a sparse matrix to solve the problem, which is solved by constructing a coefficient matrix and multiple iterations. After the algorithm is improved, this article combines the digital intelligence method to construct the digital song and dance costume design system structure based on the intelligent deep learning algorithm and analyzes its work flow. Finally, this paper verifies the method in this paper through feasibility analysis and system performance test. From the experimental results, it can be seen that the digital song and dance costume design system based on the intelligent deep learning algorithm proposed in this article has a good effect in the song and dance costume design.
Pharmacodynamics and Cellular Uptake of Peimine and Peiminine in Inflammatory Model Non-Small-Cell Lung Cancer Epithelial Cells (A549)
Authors: Chen Zhan-Ke , Zhao Di , Feng Su-Xiang , Xu Jiangyan
Published: February 2022

Peimine and peiminine are isosteroidal alkaloids with multiple biological activities, such as anticancer and anti-inflammatory activities, but their cellular uptake and pharmacodynamics are unclear. In this study, a rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the simultaneous quantification of peimine and peiminine concentrations in A549 cells. In the pharmacodynamic study, the selected inflammatory cytokines were IL-8, MMP-9, and TIMP-1. The results demonstrated that all calibration curves exhibited good linearity (r > 0.9970). The RSDs of intraday and interday precision and accuracy were less than 6.73% and 1.76% and 7.73% and 3.05% for peimine and peiminine, respectively. Moreover, the average analytic recoveries ranged from 83.85% to 113.67%, and the matrix effect was within 95.05%–111.29%. The uptake experiment showed a time-dependent characteristic in the A549 cells. The combination group had increased uptake and had a longer Tmax than the single group. In the experimental pharmacodynamics groups, the anti-inflammatory effects of the 100.0 µg/mL combination group were the most obvious. This investigation, for the first time, explores the cellular uptake profiles and pharmacodynamics of peimine and peiminine in A549 cell lines.
The Impact of Megaproject Stakeholders’ Psychological Ownership on Cooperative Innovation Performance: Territorial Behavior and Social Loafing as Mediator
Authors: Chen Zhen
Published: February 2022

Megaprojects encounter numerous innovation challenges as well as cross‐organization cooperation demands. The paper aims to clarify the relationship between stakeholders’ psychological ownership and cooperative innovation performance. It proposes modelling the behaviors’ mediator process and how and why the megaproject stakeholders’ psychological ownership impacts their cooperative innovation performance. The research aims to expand the domain of psychological ownership by temporary cross‐organization aspects and reveal behavioral influence mediation mechanism. This paper opted for an empirical study adapting the SEM approach. Tools such as pre‐survey and documentary analysis are applied to design the questionnaire scale. This paper acquired 237 valid questionnaires from seven megaprojects to validate the impact of stakeholders’ psychological ownership on cooperative innovation performance. This paper finds that the following: (1) the psychological ownership of megaproject stakeholders has a negative impact on cooperative innovation performance, which is realized through the dual mediators of territorial behavior and social loafing; (2) psychological ownership has a positive effect on both territorial behavior and social loafing, while territorial behavior and social loafing have a negative effect on cooperative innovation performance. This paper reveals that psychological ownership’s negative influence mechanism on cooperative innovation performance, in temporary cross‐organization, further provides support for improving cooperative innovation performance.
Analysis and Prediction of the Interval Duration between the First and Second Accidents considering the Spatiotemporal Threshold
Authors: Liu Fang , Zheng Lanlan , Li Mingyang , Tang Jinjun
Published: February 2022

Studying the time interval duration between the first accident and the second accident caused by it can provide decision makers with valuable information on how to effectively deal with high-risk second accidents. This paper is aimed to explore the potential influencing factors of the interval duration between the two accidents and predict it. First, the spatiotemporal definition method is applied to identify the cascaded first accident and the second accident. Then, on the basis of using Kaiser-Meyer-Olkin (KMO) measure and Bartlett’s sphere test statistics to ensure the applicability of the data to the factor analysis method, the explanatory variables that can significantly affect the interval duration are obtained through the factor analysis method. Finally, the random forest model (RF), which combines the advantages of machine learning methods, is employed to predict the duration of the interval. Traffic accident data set collected in Los Angeles city from February 2016 to June 2020 is used to validate prediction performance in this study. Bayesian method is applied to optimize the hyperparameters in the RF, while three evaluation indicators, including the Root Mean Squared Error (RMSE), Mean Squared Error (MSE), and Mean Absolute Percentage Error (MAPE), are used to estimate the prediction effect. The test results and comparative experiments confirm that RF is able to predict the interval well and has better prediction performance. This is of great significance for the prediction of the duration of the interval between one accident and the second accident.
A Chinese Named Entity Recognition Model of Maintenance Records for Power Primary Equipment Based on Progressive Multitype Feature Fusion
Authors: He Lanfei , Zhang Xuefei , Li Zhiwei , Xiao Peng , Wei Ziming , Cheng Xu , Qu Shaocheng
Published: February 2022

Presently, the State Grid Corporation of China has accumulated a large amount of maintenance records for power primary equipment. Unfortunately, most of these records are unstructured data which lead to difficultly analyze and utilize them. The emergence of natural language processing technology and deep learning methods provide a solution for unstructured text data. This paper proposes a progressive multitype feature fusion model to recognize Chinese named entity of unstructured maintenance records for power primary equipment. Firstly, the textual characteristics and word separation difficulties of maintenance records are analyzed, then 7 main entity categories of power technical terms from unstructured maintenance records are chosen, and 3452 maintenance records are labeled by these categories, which is so called EPE‐MR training dataset. Secondly, the standard test reports, standard maintenance, and fault analysis reports for three types of power primary equipment (namely, main transformer, circuit breaker, and isolating switch) are employed as corpus to train character embedding in order to obtain certain words representation ability of maintenance records. After that, progressive multilevel radicals feature extraction module is designed to get detailed and fine semantic information in a hierarchical manner. Further, radicals feature representation and character embedding are concatenated and sent to BiLSTM module to extract contextual information in order to improve Chinese entity recognition ability. Moreover, CRF is introduced to handle the dependencies among prediction labels and to output the optimal prediction sequence, which can easily obtain structured data of maintenance records. Finally, comparative experiments on public MSRA dataset, China People’s Daily corpus, and EPE‐MR dataset are implemented, respectively, which show the effectiveness of the proposed method.
Cardiac Tamponade: A Rare Manifestation of Familial Mediterranean Fever
Authors: Malek Abdolreza , Zeraati Tina , Sadr-Nabavi Ariane , Vakili Niloofar , Abbaszadegan Mohammad Reza
Published: February 2022

Familial Mediterranean fever (FMF) typically presents with recurrent attacks of fever and serosal inflammation with peritoneum, pleura, and synovium. We usually do not expect pericardial involvement at the early stages. FMF is an autoinflammatory disease, usually inherited with an autosomal recessive pattern. The patients typically have biallelic mutations in the MEFV gene, located on chromosome 16. Colchicine is the first-line treatment of FMF, which not only plays a crucial prophylactic role regarding the attack episodes, but also prevents amyloidosis. Colchicine resistance and intolerance in FMF patients have been rarely reported. Alternative anti-inflammatory agents are understood to be helpful in such cases. We describe a 13-year-old boy referred to our pediatric department complaining of chest pain, dyspnea, and tachycardia. Due to the massive pericardial and pleural effusion, a pericardiocentesis was performed, and a chest tube was inserted. Cardiac tamponade was considered as the initial diagnosis. After a month, he faced another episode of pleuritic chest pain, fever, tachycardia, and pleural and pericardial effusion. Evaluation for probable differential diagnoses including infection, malignancy, and collagen vascular disease showed no remarkable results. Finally, the mutation found by whole exome sequencing was confirmed by direct Sanger sequencing revealing a heterozygote c.44G > C (p.Glu148Gln) mutation in exon 2, confirming the clinical diagnosis of familial Mediterranean fever. Since he seemed to be nonresponsive to the maximum standard dose of colchicine, 100 mg of daily dapsone was added to his treatment regimen, which controlled the attack episodes well. FMF, while rarely initiated with cardiac manifestation, should be considered in patients with any early signs and symptoms of cardiovascular involvement.
Red Cell Distribution Width: A Clinical Indicator to Assess Severity and Guide Anti-Inflammatory Therapy in Patients with Knee Osteoarthritis
Authors: Zhang Hongjing , Shi Liwei , Tang Zhi , Rong Genxiang , Gui Binjie
Published: February 2022

To explore the influence factors of the red cell distribution width (RDW) level in knee osteoarthritis (KOA) patients, the difference in RDW before and after total knee arthroplasty (TKA), and further explain the clinical value of the RDW level in KOA patients. Information of 195 patients with KOA and 43 patients with meniscus injuries undergoing surgical treatment in the Surgery Department of Joint and Microsurgery Repair and the Surgery Department of Sports Trauma and Joint Arthroscopy of the First Affiliated Hospital of Anhui Medical University from June 1, 2020, to December 1, 2020, were collected. All included patients’ gender, age, height, medical history, blood lipid, erythrocyte sedimentation rate (ESR), CRP, RDW, anteroposterior and lateral X-ray images of the knee joint, and magnetic resonance imaging (MRI) of the knee joint were recorded. The difference in RDW of KOA patients with different severities before and after unilateral TKA surgery was compared, and the difference between KOA patients and patients with only meniscus injury was also compared for further analysis of the influence factors of the RDW level in moderate-severe KOA patients. Among moderate-severe KOA patients with different imaging severities, the RDW level was significantly different (P = 0.022). There was no statistical difference between the groups with and without the TKA history. The RDW level was higher in KOA patients than in patients with only meniscus injuries, and the difference was statistically significant

P
<
0.05

. To some extent, the RDW level could be taken as a predictor for the severity of moderate-severe KOA patients, and its elevation was primarily related to chondritis and synovitis caused by KOA, so it was suggested that the patients receive adjuvant anti-inflammation therapy after TKA surgery.
A Rare Case of Pneumococcal Appendicitis in a Child
Authors: Chikhaoui Amar , Nzoyikorera Néhémie , El Mouadden Mehdi , Al Zemmouri Mounia , Zerouali Khalid
Published: February 2022

Appendicitis is the most common cause for abdominal surgery in children. It is usually caused by Escherichia coli and Streptococcus species and is generally polymicrobial. However, Streptococcus pneumoniae is a rare cause of appendicitis. We report a rare case of pneumococcal appendicitis in a 7-year-old child with no underlying conditions, in association with E. coli and group F β-hemolytic Streptococcus. The isolated pneumococcal strain was sensible to all tested antibiotics. The patient had a full recovery after surgery and antibiotics. This case emphasizes that S. pneumoniae can cause a variety of unusual infections like appendicitis, in patients with or without underlying conditions. Thus, even though being a rare entity, physicians should always be aware of S. pneumoniae as a possible causative agent.
PGC1α/β Expression Predicts Therapeutic Response to Oxidative Phosphorylation Inhibition in Ovarian Cancer
Authors: Ghilardi Carmen , Moreira-Barbosa Catarina , Brunelli Laura , Ostano Paola , Panini Nicolò , Lupi Monica , Anastasia Alessia , Fiordaliso Fabio , Salio Monica , Formenti Laura , Russo Massimo , Arrigoni Edoardo , Chiaradonna Ferdinando , Chiorino Giovanna , Draetta Giulio , Marszalek Joseph R. , Vellano Christopher P. , Pastorelli Roberta , Bani MariaRosa , Decio Alessandra , Giavazzi Raffaella
Published: February 2022

Ovarian cancer is the deadliest gynecologic cancer, and novel therapeutic options are crucial to improve overall survival. Here we provide evidence that impairment of oxidative phosphorylation (OXPHOS) can help control ovarian cancer progression, and this benefit correlates with expression of the two mitochondrial master regulators PGC1α and PGC1β. In orthotopic patient-derived ovarian cancer xenografts (OC-PDX), concomitant high expression of PGC1α and PGC1β (PGC1α/β) fostered a unique transcriptional signature, leading to increased mitochondrial abundance, enhanced tricarboxylic acid cycling, and elevated cellular respiration that ultimately conferred vulnerability to OXPHOS inhibition. Treatment with the respiratory chain complex I inhibitor IACS-010759 caused mitochondrial swelling and ATP depletion that consequently delayed malignant progression and prolonged the lifespan of high PGC1α/β-expressing OC-PDX-bearing mice. Conversely, low PGC1α/β OC-PDXs were not affected by IACS-010759, thus pinpointing a selective antitumor effect of OXPHOS inhibition. The clinical relevance of these findings was substantiated by analysis of ovarian cancer patient datasets, which showed that 25% of all cases displayed high PGC1α/β expression along with an activated mitochondrial gene program. This study endorses the use of OXPHOS inhibitors to manage ovarian cancer and identifies the high expression of both PGC1α and β as biomarkers to refine the selection of patients likely to benefit most from this therapy.

Significance:

OXPHOS inhibition in ovarian cancer can exploit the metabolic vulnerabilities conferred by high PGC1α/β expression and offers an effective approach to manage patients on the basis of PGC1α/β expression.
Patella Locking Star-Plate as Salvage to the Failed Tension Band Wiring for a Patella Fracture: A Case Report
Authors: Bansal Hemant , Behera Abhijit , Sharma Vijay , Farooque Kamran
Published: February 2022

The integrity of the patella is pivotal for the efficient functioning of the knee extensor mechanism. Thus, patella fracture management cannot be neglected and utmost priority should be determined for its preservation and maintenance of knee functioning. Tension band wiring (TBW) is the most widely and commonly used mode of fixation of patella fractures with consistently favourable outcomes. However, the complications associated with the same could be challenging and may compromise the integrity of the patella. This case report highlights the salvage of the failed TBW for a patella fracture with biomechanically stronger angular stable Star-shaped patella plate.
Association of Urine Albumin-Creatinine Ratio and Cystatin C-Based Estimated GFR with Outcomes in Patients with Ischemic Stroke
Authors: Zhou Yilun , Wu Yu , Pan Yuesong , Li Hao , Yan Hongyi , Meng Xia , Lin Jinxi , Wang Hong , Matsushita Kunihiro , Wang Yongjun
Published: February 2022

Background/Aims: Data about the independent and combined effects of cystatin C-based estimated glomerular filtration rate (eGFRcys) and albuminuria on the risk of poor outcome in stroke patients are limited. The aim was to elucidate how these two renal markers affect the clinical outcomes after ischemic stroke separately and jointly. Methods: The study subjects consisted of 10,197 patients with ischemic stroke from the third China National Stroke Registry. The study outcomes were all-cause mortality, poststroke disability, recurrence of stroke, and cardiocerebral vascular disease (CVD) composite events. Cox proportional hazard models and multivariable logistic regression model were applied to evaluate the effects of eGFRcys and urine albumin-creatinine ratio (ACR) on these outcomes. Results: Both reduced eGFRcys and increased ACR were independently associated with higher incidences of all-cause death and poststroke disability (p < 0.01). Mildly decreased eGFRcys (60–89 mL/min/1.73 m2) is associated with increased risk of all-cause death and poststroke disability in the presence of high-normal ACR (10–29 mg/g). Patients with both eGFRcys <45 mL/min/1.73 m2 and ACR ≥30 mg/g at baseline had a 6.8-fold risk for all-cause mortality and 3.6-fold risk for poststroke disability, compared with patients with eGFRcys of 90–119 mL/min/1.73 m2 and ACR <10 mg/g. In addition, increased ACR was associated with recurrent stroke and CVD composite event, while reduced eGFRcys showed no relationship with these outcomes. Conclusions: Both decreased eGFRcys and albuminuria are independent risk factors for all-cause death and poststroke disability. Combining the two markers is useful for improving risk stratification even in those without chronic kidney disease.
A new species of Ophtalmibidion Martins from French Guiana, and notes on O. luscum Martins (Coleoptera, Cerambycidae, Cerambycinae)
Authors: Vlasak Josef , Santos-Silva Antonio
Published: February 2022

Ophtalmibidion gutta sp. nov. is described from French Guiana. The elytral color pattern of Ophtalmibidion luscum Martins, 1971 is commented on. A key to species of Ophtalmibidion is provided as well as photographs of all species.
Estudo das paráfrases em HQs baseadas em Noite na taverna, de Álvares de Azevedo
Authors: Nobre Kennedy Cabral , Delfino Celeste Cristina Andrade
Published: February 2022

Tem como objetivo analisar como a obra Noite na Taverna, de Álvares de Azevedo (2005), foi parafraseada nas adaptações para histórias em quadrinhos de Seriacopi (2011) e Patati (2013), levando-se em consideração as perspectivas teóricas de Fuchs (1985; 1982). A metodologia utilizada foi pesquisa quantitativo-qualitativa. Na pesquisa quantitativa realizamos, após a seleção das paráfrases da obra original, a coleta e a análise dos dados através de procedimentos estatísticos, utilizando gráficos que apresentaram as paráfrases e as reproduções ipsis litteris. Quanto à pesquisa qualitativa, realizamos a análise das paráfrases a partir das categorias de Fuchs (1985): perspectiva lógica da equivalência, perspectiva gramatical da sinonímia e perspectiva retórica da reformulação; e de Fuchs (1982) plano locutivo, plano referencial, plano pragmático e plano simbólico. Os resultados apontam que grande parte da adaptação se vale do recurso de reprodução ipsis litteris do texto original. No que tange às paráfrases propriamente ditas, há predomínio da perspectiva lógica da equivalência, seguida da perspectiva retórica da reformulação e, com menor recorrência, a perspectiva gramatical da sinonímia. No que diz respeito aos planos, há predominância do plano locutivo e quase nenhum uso de paráfrase em plano simbólico, certamente para preservar as ideias do original.
Texto Homenagem: Os sofrimentos do jovem Alencar
Authors: Marques Wilton José
Published: February 2022

Este artigo trata de um aspecto pouco conhecido da produção literária de José de Alencar, isto é, sua poesia. Nesse sentido, discute alguns poemas e um fragmento de crônica inédita que expressam sofrimentos amorosos motivados por uma malograda relação amorosa de juventude.
Visualidade e audiodescrição: a cena teatral sob o ponto de vista da deficiência visual
Authors: Alves Jefferson Fernandes , Cerejeira Thiago de Lima Torreão
Published: February 2022

O presente artigo enfoca a questão da visualidade como orquestradora da cena teatral, levando em conta o processo tradutório por meio da audiodescrição (AD), na perspectiva da fruição espetacular por parte de pessoas com deficiência visual. Com o propósito de explorar tal enfoque, abordaremos o caráter tradutório da audiodescrição e sua articulação com o teatro. Em seguida, centraremos em uma experiência de audiodescrição, ainda em curso, do espetáculo “Abrazo”, do Grupo Clowns de Shakespeare – Natal/RN. E, por fim, priorizaremos a reflexão sobre a audiodescrição como uma prática de expansão do olhar, retomando a natureza etimológica do teatro, de tal modo que o enfoque estético da audiodescrição possa acompanhar a poética da cena, a partir da deficiência visual.
A batalha pela vacina: a corrida pela imunização num cenário de escassez e o papel do consórcio Covax Facility
Authors: Silva Victor Carvalho Pessoa de Barros e
Published: February 2022

O presente texto tem como finalidade realizar um estudo analítico relacionado às ações governamentais na prestação da saúde pública, em específico, na vacinação contra o Covid-19. A partir de reflexões teóricas, o artigo visa examinar o papel do Estado ante a distribuição de vacinas, tendo como objetivo perpassar por uma análise da escassez. Além disso, o trabalho se propõe a apresentar medidas concretas que fortalecem a cidadania e a sustentabilidade social, como o consórcio Covax Facility e a suspensão dos direitos de propriedade intelectual das vacinas.
A Administração Pública Penitenciária: um cenário crônico de ineficiência e ilegalidades no Brasil pós Constituição de 1988
Authors: Zambrota Luciano
Published: February 2022

Com suporte na teoria do garantismo constitucional de Luigi Ferrajoli, o artigo analisa o cenário de ineficiência administrativa junto ao sistema prisional brasileiro, com enfoque para os dados e números do déficit de vagas e consequente superlotação carcerária. A partir do diálogo com os ensinamentos de Argemiro Cardoso Moreira Martins, sustenta-se que a Administração Pública penitenciária precisa se tornar mais democrática, para congregar a participação popular e da sociedade civil na administração do sistema prisional, como alternativa para alcançar melhores resultados de qualidade junto ao setor, apontado como ineficiente pelo Tribunal de Contas da União e como desumano ou degradante, consoante a classificação do Supremo Tribunal Federal. Por fim, sugere-se que os agentes estatais incumbidos da administração prisional precisam ser responsabilizados com maior rigor, para evitar que a falta de prioridade política e eficiência administrativa continuem a permitir a violação dos direitos fundamentais do preso.
Percepções da paisagem da Serra da Capivara-PI
Authors: Figueiredo Diva Maria Freire , Lopes Myriam Bahia
Published: February 2022

Neste artigo lançamos mão da geografia e da história para realizar um estudo da paisagem da Serra da Capivara. A revisão da literatura científica e de fontes documentais da UNESCO, IPHAN, reportagens impressas, audiovisuais e registros orais editados e publicados compõem um mosaico acerca das mudanças físicas e percepções da paisagem da Serra da Capivara. Os relatos de antigos moradores sobre essa paisagem, hoje desabitada e tutelada pelo Estado, assim como as visões dos pesquisadores, nos auxiliam a compreender a singularidade desse lugar. Nesse artigo, indicamos o encontro de quatro campos envolvidos no tema: história, patrimônio cultural, ciência arqueológica e proteção ao meio ambiente. A Serra da Capivara é objeto de políticas públicas de preservação do patrimônio cultural e natural. E a patrimonialização está presente nas abordagens dessa paisagem. No entanto, sua interpretação em documentos relacionados à tutela nacional e internacional do patrimônio revela a permanência de ambiguidades. O uso do binômio natureza/cultura como fundamento dos textos precisa ser superado.
The Notion of Institutional Practice in United Nations Law
Authors: Gasbarri Lorenzo
Published: February 2022

This paper aims to define the notion of institutional practice and it examines the extent to which United Nations organs and Member States can rely on and are limited by it. It describes all the normative theories involved, and proposes a simplified and comprehensive framework. The core argument is that institutional practice is less relevant than it seems in the first instance and, generally, it cannot do much by itself. It requires a further element to produce normative effects, whether in the form of Member States’ practice or other means of interpretation of the constitutive instrument. After a brief introduction, the second section focuses on what constitutes institutional practice, distinguishing between the problem of the acts that constitute practice and how they are attributed to the organisation. Section iii discusses its employment by the International Law Commission, which distinguishes ‘subsequent’ institutional practice as a means of interpretation of the constitutive instrument, ‘general’ institutional practice as an element of customary law, and ‘established’ institutional practice as a rule of the organisation. Finally, Section iv provides a general overview of the normative relevance of institutional practice. The Conclusion summarizes these main findings.