bluuebunny/crossref_metadata_2025 huggingface dataset:
Purification of Pharmaceuticals via Retention Time Prediction: Leveraging Graph Invariant Networks, Limited Data, and Transfer Learning
Authors: Beck Armen G. , Shrestha Rojan , Wang Jun , Fine Jonathan , Regalado Erik L. , Hettiarachchi Kanaka , Williams Katharine B. , Sherer Edward C. , Aggarwal Pankaj
Published: January 2025

The design-make-test cycle for drug discovery is highly dependent on the purification of synthesized compounds. Prior to evaluation of suitability, ultrahigh performance liquid chromatography is used for an initial standard analysis, where retention times of analytes are measured with a shorter standard gradient method and used to select the appropriate gradients for a final purification method. To circumvent this preliminary screening experiment for small molecule libraries, retention time prediction had been achieved previously by use of commercial modeling methods. However, these retention time prediction models can have limited applicability when built from smaller datasets and are less effective when constructed from disparate data collected under differing chromatography conditions. Having thousands of measured retention times from high-throughput physiochemical screening, we sought to leverage these data for the construction of predictive models for a standard preliminary method enabling high-throughput purification of macrocyclic peptide libraries. Utilizing 4549 analytes and their retention times from high-throughput physiochemical screening, a structure to retention time model was built using a graph invariant network, a form of artificial neural network architecture. Once fitted to high-throughput screening data, the model was re-trained with standard gradient method data, a technique known as transfer learning. Through transfer learning, a training set of 80 analytes yielded a neural network model, that when evaluated against a test set of 24 analytes, displays high performance metrics with a coefficient of determination (R2) of 0.82 and mean average error of 0.088 minutes, or 1.26% of the gradient time. This model has been deployed internally as a dash-app to help democratize the use of the developed models and is being used for selecting purification methods based on analyte structure.
Extending the MMPBSA method to membrane proteins: Addressing conformational changes upon ligand binding to P2Y12R
Authors: Zhao Cizhang , Wang Tianhong , Luo Ray
Published: January 2025

Membrane proteins play crucial roles in biological signaling and represent key targets in drug discovery, garnering significant experimental and computational attention. Recent advances in computational screening techniques have enabled the development of more accurate and efficient binding affinity calculation methods. Among these, the Molecular Mechanics Poisson Boltzmann Surface Area (MMPBSA) method has gained widespread adoption in large-scale simulations due to its computational efficiency. However, its application to membrane protein-ligand systems remains less developed compared to globular protein systems, primarily due to the additional complexity introduced by the membrane environment. In this study, we present enhanced capabilities in Amber that provide flexible and automatic options for calculating membrane placement parameters. Furthermore, we present the first application of ensemble simulations, combined with a multi-trajectory approach and entropy corrections, to enhance MMPBSA calculations for membrane protein systems. This novel methodology is particularly advantageous for systems exhibiting large ligand-induced conformational changes, significantly improving accuracy and sampling depth compared to traditional single-trajectory methods. We validate our approach using the human purinergic platelet receptor P2Y12R as a model system, chosen for its well-documented agonist-induced conformational changes and extensive experimental data, making it an ideal candidate for evaluating our enhanced simulation protocol.
Evaluating the prevalence, identifying triggers, and classifying the triggers within the patients suffering from migraine
Authors: Chakra R Gautham , Priya B Chandana , Bhuvaneswari D , Gowsalya P , Likhitha K , Gowtham K Pavan
Published: January 2025

Migraine is a neurological condition often presenting as severe, pulsating headaches on one side of the brain. These episodes can last hours or days, significantly interfering with daily activities. This study aimed to evaluate the prevalence, identify triggers, and classify them among migraine patients. A prospective study was conducted in the Neurology Outpatient Department of KIMS Hospital, Nellore, over six months (November 2024 to May 2025). Data were collected via a specially designed questionnaire to obtain baseline information.Results: The study included 103 patients, with 82 (79.6%) females and 21 (20.4%) males. Among them, 61 (59.2%) reported migraines lasting years, 26 (25.2%) for months, and 16 (15.6%) for days. Duration of headache episodes varied, with 64 (62.1%) experiencing headaches for hours, 23 (22.3%) for minutes, and 16 (15.6%) for days. The prevalence rate was 51.5%. Patients identified various triggers, which were classified accordingly.Conclusion: The prevalence of migraines was 51.5%, highlighting a significant burden of this condition. Despite its impact, limited awareness persists. Recognizable triggers identified by patients can guide tailored treatment adjustments. This study equips primary care physicians with valuable insights to educate patients and develop effective management strategies, ultimately improving the quality of life for individuals suffering from migraines.
Farmácia Verde na Escola: uma proposta extensiva para abordagem do descarte de medicamentos com estudantes do ensino fundamental
Authors: Campos Náira da Silva , Silva Ana Letícia Bastos , Pinto Júlia de Andrade Araújo , Ribeiro Sara Gabriela Pereira Silva , Rossi Talita Melissa , Silva Carolina Assunção Lucas da
Published: January 2025

O desenvolvimento de formulações farmacêuticas configura em avanço e transformação das atividades de assistência à saúde estabelecidas na Política Nacional de Medicamentos. Contudo, atrelado a este desenvolvimento, destacam-se as questões ambientais e de saúde pública relacionadas ao descarte inadequado de medicamentos não utilizados. A literatura mostra que a população brasileira descarta este tipo de produto geralmente no vaso sanitário e no lixo comum, gerando impactos ambientais em solos e corpos d’água. Neste sentido, o desenvolvimento de atividades educativas que abordem o tema em diferentes níveis sociais, educacionais e culturais são essenciais para o desenvolvimento sustentável, uma demanda mundial estabelecida pela Organização das Nações Unidas. O projeto de extensão Farmácia Verde na Escola, da Universidade de Brasília, visa a promoção de educação ambiental para estudantes da rede pública de ensino do Distrito Federal (DF), empregando como recurso didático uma peça teatral com fantoches. Este artigo descreve um relato de experiência da ação teatral realizada com 50 crianças com idades entre 9 e 10 anos do 4º ano do ensino fundamental da Escola Classe 01 de Taguatinga-DF. O descarte de resíduos e de medicamentos foi abordado através da apresentação teatral, uma atividade lúdica produzida com linguagem apropriada ao público infantil. As atividades realizadas após as ações permitiram observar e concluir que as crianças internalizaram as formas corretas de descartar medicamentos e resíduos. Conclui-se que metodologias de ensino diferentes do modelo tradicional da sala de aula podem ser ferramentas interessantes para abordar temas complexos, tais como o descarte de medicamentos, com estudantes do ensino fundamental. Atividades lúdicas como as apresentadas neste estudo são ferramentas interessantes de ensino e que podem facilitar o processo de aprendizagem, seja pela introdução de novos conceitos ou pela fixação de conteúdos já trabalhados em sala de aula e/ou vivenciados no ambiente familiar.
Uso de histogramas na predição de esteatose hepática em cadelas obesas submetidas à dieta e sua correlação com achados ultrassonográficos (modo B e Doppler Colorido)
Authors: Disselli Tamiris , Pires Sâmara Turbay , Ercolin Anna Carolina Mazeto , Stanquini Camila Silveira , Andrade Amanda Moura Rocha de , Passarelli Danielle , Tech Adriano Rogério Bruno , Lima César Gonçalves de , Gomes Diego Rodrigues , Ramos Denise Jaques , Hage Maria Cristina Ferrarini Nunes Soares
Published: January 2025

Sabe-se que a ultrassonografia é uma ferramenta diagnóstica acessível e economicamente viável, sendo considerada de eleição para a avaliação hepática. Pretendeu-se com este estudo avaliar qualitativamente (ultrassonografia modo B) e quantitativamente (histogramas em escala de cinza) o fígado de 28 cadelas em diferentes escores de condição corporal (ECC) quanto à presença de infiltração gordurosa; e a veia hepática direita (VHD) (modo B e modo Doppler colorido) quanto à sua visibilidade e presença de fluxo sanguíneo, respectivamente. A hipótese do presente estudo foi que a perda de peso reduziria a gordura hepática e, consequentemente, cessaria seu efeito mecânico sobre o lúmen venoso. Com isso, dividiu-se os cães do estudo em três grupos, de acordo com seu ECC: controle (ECC 4 ou 5), sobrepeso (ECC 6 ou 7) e obeso (ECC 8 ou 9), sendo este submetido à dieta, acompanhamento ultrassonográfico hepático e mensuração seriada de fosfatase alcalina (FA) e alanina aminotransferase (ALT). A dieta foi eficaz para o emagrecimento dos cães, porém a perda de peso não demonstrou efeitos sobre a VHD ou enzimas hepáticas. A utilização de histogramas auxiliou na detecção da gordura hepática e de sua redução ao longo da perda de peso do animal. Sendo assim, esta pode ser considerada uma ferramenta útil e de fácil execução, contribuindo no diagnóstico precoce e monitoramento da esteatose de forma não invasiva.
Soroprevalência de Leishmania infantum em cães da mesorregião Centro-Norte do estado do Piauí
Authors: Brito Mariana Castro , Silva Luise Nicole da , Oliveira Marlene Sipaúba de , Sousa Richard Átila de , Batista Ianete Lima , Mendonça Ivete Lopes de
Published: January 2025

A leishmaniose visceral (LV) é uma doença causada pelo protozoário Leishmania infantum, sendo considerado o cão (Canis familiaris) como principal reservatório da doença no meio urbano. A doença é endêmica no estado do Piauí e há uma tendência crescente em algumas regiões do estado. A detecção de novas áreas com ocorrência de LV canina é o marco para iniciar a investigação, vigilância e monitoramento epidemiológico. Objetivou-se avaliar a soroprevalência de Leishmania infantum em cães do município de Domingos Mourão, Piauí, e relatar os sinais clínicos sugestivos da doença. Foram coletadas amostras de sangue para obtenção de soro de 231 cães, das quais 174 da zona rural e 57 da zona urbana, tendo sido todos os animais submetidos à avaliação clínica para registro dos sinais clínicos sugestivos de leishmaniose canina. As amostras de soro foram submetidas ao Teste Rápido Dual Path Platform (TR DPP®, Biomanguinhos) para triagem e posteriormente as amostras foram submetidas ao ensaio imunoenzimático (ELISA®, Biomanguinhos). Os sinais clínicos mais comumente observados foram onicogrifose (93,10%), aumento dos linfonodos poplíteos (75,86%) e emagrecimento (27,58%). Das amostras analisadas, 12,56% (29/231) foram reagentes, 82,68% (191/231) não reagentes e 4,76% (11/231) indeterminadas. Na zona urbana, 12,28% (7/57) foram reagentes, 85,97% (49/57) não reagentes e 1,75% (1/57) indeterminadas. Na zona rural, 12,64% (22/174) foram reagentes, 81,61% (142/174) não reagentes e 5,75% (10/174) indeterminadas, confirmando a presença de anticorpos anti-Leishmania infantum circulantes em cães no município através do método ELISA e alertando para implementação de ações de vigilância e controle, no sentido de evitar a dispersão da doença e a ocorrência de casos humanos.
Patterns of milk productivity associated with biochemical parameters and expressions of the HSPs and Toll Like genes in dairy buffaloes
Authors: Nogueira Henrique Low , Sousa Elem Cristina Macedo Barra de , Santos Cintia Luana Pinheiro , Silva Filho Ednaldo , Santana Priscila Di Paula Bessa
Published: January 2025

The aim of this study was to verify milk productivity associated with biochemical parameters and expression of stress marker genes (HSP70, HSP90?, HSP90?) and immunity (TLR-2 and TLR-4) in dairy buffaloes. For this purpose, 12 buffaloes with an average production of 5.93 liters/day (highest production group, n=6) and 3.46 liters/day (lowest production group, n=6) were evaluated. As a result, the groups did not differ (P>0.05) regarding the biochemical analysis of proteins (4.16% versus 4.61%, p=0.13), lipids (5.80% versus 4.87%, p=0.69), lactose (4.74% versus 4.43%, p=0.83) and cortisol quantification (0.67 versus 0.79, p=0.12). The somatic cell count (106.4 versus 139, p=0.36) was within the normal range, indicating the absence of an inflammatory process in the breasts. Relative quantification was higher in the lower yield group compared to the higher yield group (P<0.05) in all genes studied: HSP70 (0.96 versus 0.58, p=0.02), HSP90? (0.98 versus 0.03, p=0.003), HSP90? (0.95 versus 0.48, p=0.03), TLR-2 (1.02 versus 0.16, p=0.008) and TLR-4 (1.26 versus 0.07, p=0.007). Furthermore, Pearson's linear correlation test indicated a negative association between production and expression of HSP90? (r=-0.89, p=0.0001), HSP90? (r=-0.66, p=0.018), TLR-2 (r=-0.72, p=0.001) and TLR-4 (r=-0.67, p=0.01). Despite the difference in production between the groups, milk quality did not differ, nor did cortisol levels, suggesting the absence of physiological stress. However, according to the negative association identified, the higher the daily milk production, the lower the expression of stress and immunity marker genes, suggesting that stress at the cellular level impairs milk production in buffaloes.
Delayed Acute Ischemia as a Consequence of Multi-Ligament Injury of the Left Knee Following a Motorcycle Accident
Authors: Leci Tahiri Laura , Tahiri Lisa
Published: January 2025

Motorcycle accidents can cause complex orthopedic and vascular injuries, posing diagnostic and treatment challenges. We present a case of a 34-year-old Albanian man with a multi-ligament knee injury and arterial thrombosis in his left leg following a motorcycle accident. The patient initially received conservative care but developed severe leg pain, coldness, and numbness, prompting urgent vascular imaging. Imaging confirmed popliteal artery thrombosis, necessitating surgical intervention. This case highlights the severe complications of motorcycle accidents, emphasizing the need for prompt vascular injury detection and a multidisciplinary approach in trauma management. Early recognition and timely intervention are crucial to prevent long-term morbidity and to optimize recovery. Further research is needed to improve diagnostic and treatment strategies for vascular complications in such injuries.
Implementasi You Look Only Once (Yolo) Untuk Manajemen Parkir Di PT. Royal Dparagon Land
Authors: Harsadi Paulus , Ramadhan Ilham
Published: January 2025

PT Royal D'paragon Land merupakan perusahaan pengelola perhotelan yang secara konsisten menyediakan hunian sementara berupa rumah kos dan guest house eksklusif. Di tempat ini sering terjadi kepadatan dan kesulitan mencari tempat parkir yang kosong terutama bagi pengguna mobil karena tempatnya yang sempit dan terbatas. Tujuan dari penelitian ini adalah merancang dan membangun sistem dengan menggunakan metode You Look Only Once (YOLO) sebagai sistem deteksi manajemen parkir di PT. Royal D'Paragon Land. Dalam merancang laporan skripsi ini, metode pengumpulan data yang digunakan untuk menyelesaikan berbagai permasalahan yang terjadi adalah observasi, wawancara dan studi pustaka. Kemudian metode yang digunakan untuk pengembangan sistem adalah Waterfall, dan bahasa pemrograman yang digunakan adalah Python. Pada tahap pengujian sistem, metode yang digunakan adalah pengujian Image Processing untuk menguji fungsionalitas sistem dan User Acceptance Test (UAT) untuk menguji validitas sistem. Hasil yang diperoleh dari penelitian ini adalah penerapan sistem informasi You Look Only Once (YOLO) untuk manajemen parkir yang meliputi deteksi mobil, tempat parkir dan lahan yang tersedia serta tampilan secara real time pada website. Penelitian ini telah diuji menggunakan metode Image Processing yang menunjukkan bahwa keseluruhan sistem dapat berfungsi sesuai dengan yang diharapkan. Dan hasil pengujian User Acceptance Test didapatkan rata-rata sebesar 96,25% termasuk dalam kategori sangat baik.
Implementasi Teknologi Blockchain dalam Digital Marketing
Authors: Solechan Achmad , Abidin Rohmad
Published: January 2025

This research was conducted because many parties feel that their privacy has been invaded as marketers. collecting internet user data. Some respondents were concerned about their privacy on the use of digital marketing, especially the abuse of their privacy related to user data. The size of the blockchain technology market worldwide in 2018 to 2025, where it is estimated that in 2025, the blockchain technology market will have a size of $ 39.7 billion. The graph shows the blockchain market prediction which also shows the adoption of the use of blockchain technology. Therefore, this study aims to determine the implementation of blockchain in the world of digital marketing in a literature review study. This study uses a qualitative method with a literature review technique with the results discussing 26 published research articles relevant to this research. The research results show that blockchain has great potential in digital marketing, especially in increasing trust, transparency, and efficiency. However, the adoption of this technology faces challenges in the form of technological literacy and significant investment. A mature implementation strategy is needed to fully utilize the potential of blockchain in the digital marketing sector.
Implementasi Metode Hybrid AHP dan MAUT dalam Sistem Pendukung Keputusan Pemilihan Indekos di Karang Joang Kota Balikpapan
Authors: Fadhliana Nisa Rizqiya , Paninggalih Ramadhan , Perwita Yustika , Nuryono Aninditya Anggari
Published: January 2025

Indekos merupakan sarana penunjang bagi Mahasiswa yang berasal dai luar kota. Dengan adanya beberapa perguruan tinggi di Kelurahan Karang Joang, Kota Balikpapan, Kalimantan Timur, seperti Institut Teknologi Kalimantan (ITK), Politeknik Negeri Balikpapan, dan Sekolah Tinggi Teknologi Minyak dan Gas Bumi (STT Migas), maka semakin banyak mahasiswa baru yang membutuhkan tempat tinggal sementara yang dekat dengan pusat pendidikan mereka. Namun, pemilihan indekos yang sesuai dengan preferensi dan kebutuhan calon penyewa menjadi hal krusial dikarenakan setiap orang memiliki tingkat kepentingan yang berbeda-beda. Oleh karena itu, untuk membantu pemilihan indekos yang tepat maka dikembangkan Sistem Pendukung Keputusan yang memberikan rekomendasi berdasarkan kriteria dan subkriteria tertentu. Sistem Pendukung Keputusan (SPK) yang dibangun dengan mengimplementasikan pendekatan hybrid AHP dan MAUT. Kedua pendekatan tersebut dapat memberikan rekomendasi indekos berdasarkan peringkat nilai utilitas tertinggi. Pengujian terhadap SPK dilakukan dengan input satu pengguna dan dua pengguna. Hasil pengujian menunjukkan bahwa untuk input satu pengguna, bobot kriteria tertinggi adalah kondisi kamar indekos dengan nilai 0.54173. Sementara itu, untuk input dua pengguna, bobot kriteria tertinggi adalah lokasi dengan nilai 0.45223.
Salary Negotiation among Dietetics Professionals: Lived Experiences and a Three-Pronged Approach to Advancing Negotiation Skills and Confidence
Authors: Shinn Leila , Hinck Suzi , Jones Lisa , Goldberg Katie , Paczosa Adrien , McKinley Erin
Published: January 2025

There is a lack of tools and training to assist in salary and benefit (S&B) negotiations within the nutrition profession. This study is the first to analyze thoughts, feelings, and experiences with S&B negotiations among nutrition and dietetics professionals. The 32-item, web-based, cross-sectional survey study was completed by English-speaking individuals of any gender who identified as a “nutrition and dietetics professional,” were 18 years of age or older in the United States or US Territory. Participant demographics, experience, confidence, and success with negotiation of S&B, value of negotiation, and interest in learning more were the primary outcome measures determined before data collection. Means, standard deviations, and ranges were calculated for ordinal data with frequencies on nominal data. ANOVAs were conducted to evaluate relationships between demographics and negotiation. Participants (N = 1239) were mostly white (90.2%), female (94.5%), registered dietitian (RD) (96.8%) members of the Academy of Nutrition and Dietetics (96.1%). Clinical practitioners accounted for the largest practice area (38.5%). Non-RD professionals had a significantly higher mean for experience with negotiation than RD’s, DTR’s and participants eligible for the RD exam (P = 0.008) and had higher confidence (P = 0.001). Clinical dietitians had significantly lower satisfaction with current salary (P < 0.001) and experience (P < 0.001), confidence (P < 0.001), and success (P < 0.001) with negotiation but had significantly higher interest in advancing negotiation skills (P = 0.017) than all other practice areas. Early education, exposure, and empowerment are key factors in improving the negotiation experience that begins in the undergraduate experience and continues well into professional practice.
Kualitas Laporan Keuangan Ditinjau dari Enterprise Risk Management
Authors: Maghfirotuzzahro Fiinaa , Tyas Dwi Aryani Alvita , Gunawan Ade
Published: January 2025

Financial reports play a crucial role for external parties in monitoring company performance, tracking growth, and evaluating achievements. However, pressure to make reports appealing to prospective investors and stakeholders often leads to financial statement manipulation. Stakeholder theory asserts that financial reports are needed by various parties to assess company operations and aid in investment decision-making. Nevertheless, this manipulation can result in a mismatch between external expectations of neutral reports and company practices of embellishing financial statements. This study aims to provide a deeper understanding of how Intellectual Capital, Sustainability Reports, and Tax Planning affect the quality of financial reports, moderated by Enterprise Risk Management, in the transportation and logistics sector companies listed on the Indonesia Stock Exchange (BEI) from 2019 to 2023. A causal-comparative method is employed with a quantitative approach and data collection from company financial reports and annual reports from 2019 to 2023. Moderated Regression Analysis (MRA) using Eviews 13 is the data analysis technique utilized. The research findings indicate that Intellectual Capital, Sustainability Reports, and Tax Planning influence the quality of financial reports. However, Enterprise Risk Management only moderates the influence of Sustainability Reports, weakening their impact on financial report quality, but not that of Intellectual Capital and Tax Planning.
Digital Innovation in Arabic Language Learning Models for Islamic Higher Education
Authors: Wahyuni Imelda , Zulaeha  , Budiarti  , Nasiru LM Akramullah
Published: January 2025

This study aims to examine the innovation of digital-based Arabic learning models, particularly regarding Human Resource (HR) innovations and the utilization of digital facilities at three Islamic Higher Education (Perguruan Tinggi Keagamaan Islam/PTKI) Institutions in Southeast Sulawesi. This qualitative research employs a phenomenological approach, with data collected from primary and secondary sources through observation, interviews, Focus Group Discussions (FGD), and document studies. The data was analyzed using categorization, description, and synthesis techniques, with data validity tested through triangulation. The findings of this article indicate that the State Islamic Institute (IAIN) Kendari, the Islamic College (STAI) YPIQ Baubau, and the Islamic Institute (IAI) Al-Mawaddah Warahmah Kolaka have implemented innovations in digital-based Arabic learning models. The creativity of human resources (lecturers, students, and administrative staff) shows different adaptation styles in utilizing digital facilities. These innovations have facilitated Arabic language learning but have not been fully supported by the digital competence of human resources at these three institutions. In terms of digital facilities meeting standard requirements, the three Islamic Higher Education Institutions exhibit varying levels of innovation in digital-based Arabic learning models, especially in operational digital formats, HR competence readiness, and availability of facilities. The digital-based Arabic learning model innovations at these institutions offer advantages, compatibility, and religious complexity. These innovations are implemented with a commitment to enhancing HR creativity and providing representative digital facilities based on needs.
Hegemony of Pesantren Ulama in the Contemporary Political Dynamics of Central Java
Authors: Yahya Imam , Ananda Muhammad Aflahmuna
Published: January 2025

This study aims to examine the hegemony of religious leaders (Ulama) in contemporary politics and how Ulama exercise their hegemonic roles in the political process in Central Java. Data was obtained through primary and secondary sources, with primary data collected through field research using interviews, and secondary data gathered through literature research. The findings indicate that the entanglement between Ulama and politics is caused by two factors: political oligarchy within political parties and the political hegemony of Ulama. The political hegemony of Ulama in the political constellation of Central Java makes them highly influential in political affairs. However, from the perspective of real political dimensions in Central Java, Ulama have yet to secure strategic positions in either the executive or legislative branches.
Indigenous Peoples, Religious Conversion, and the Politics of Religion in Indonesia
Authors: Suryani Ade Jaya
Published: January 2025

This study delves into the intricate relationship between political influences and religious conversion in Indonesia, with a particular emphasis on the experiences of Indigenous Peoples such as the Baduy in Banten, the Akur Sunda Wiwitan in West Java, and the Suku Anak Dalam in Jambi. The research adopts a qualitative methodology, incorporating interviews, journalistic reports, government regulations, and detailed case studies to examine how state policies and socio-political pressures contribute to the decision of these communities to convert. The findings indicate that state policies, often rooted in a narrow understanding of religious identity, exert considerable pressure on indigenous groups, prompting conversions that are frequently motivated by the need for social acceptance and political survival. This research highlights the significant role of political dynamics in shaping religious identities in Indonesia and underscores the urgent need for more inclusive and equitable policies that honor and protect the religious diversity of the nation’s indigenous populations.
Poligami Dalam Prespektif Al-Qur`An Dan Hadis
Authors: M wildanul ulum Wildanul ulum Ulum , Aulia Naja Tsabita , Rohmah Siti Solikhatul
Published: January 2025

Praktek poligami telah ada jauh sebelum Islam dan menjadi sebuah kebiasaan yang dibolehkan. Sayangnya,banyak orang beranggapan bahwa poligami merupakan praktek yang baru dikenal setelah hadirnya Islam.Ironisnya, Islam dianggap memonopoli dan yang melegalkan poligami. Pada kenyataannya, Islam datangdengan memberikan batasan gerak terhadap perkawinan poligami dengan batasan tertentu. Keadilan dalamberpoligami merupakan satu kewajiban yang harus mendapatkan perhatian khusus, karena kata “adil” sangatmudah diucapkan akan tetapi sulit dilaksanakan. Dalam penelitian ini penulis menfokuskan pada ayat al-Qur’andan hadis yang berkaitan dengan poligami yaitu; Surah An-Nisa’ ayat 3 dan beberapa hadis shahih terkaitpoligami. Jenis penelitian ini sepenuhnya adalah penelitian kepustakaan (library researcah) mengambil data dariliteratur yang ada kaitannya dengan tema penelitian. Teknik analisa dalam penulisan ini menggunakan modelanalisis isi dengan menggali dan menganalisis pemikiran atau pandangan para ulama terhadap ayat Al-Qur’andan hadis yang berkaitan dengan poligami.
The Crack Propagation in Different Rock Types: A Comparative Seismic Simulation
Authors: Mughieda Omer , Kaiwaan Abdulhai , Azimi Sayed Javid , Namdar Abdoullah , Liu Yuyi , Alzaylaie Marwan
Published: January 2025

The presence of a preexisting crack in a rock can affect its stability during seismic events, leading to reduced strength and stiffness. This study, which aims to examine how different types of preexisting fracture angles and the mechanical properties of the rock impact real-time cracking propagation modes and crack propagation shape, has practical implications. The researchers used ABAQUS software to apply simulated seismic loading to their model and studied crack propagation using the extended finite element method (XFEM). They found that the crack propagation shape and real-time cracking propagation vary based on the preexisting fracture angles and the mechanical properties of the rock. Additionally, they observed a significant relationship between strain leading to nonlinear deformations and the mechanical properties and fracture seismic toughness mechanism. These findings can be applied to improve the prediction of failure mechanisms in rocks with different crack shapes and could potentially enhance seismic response simulation and geotechnical earthquake engineering codes. The numerical simulation results were validated and compared to existing literature, further highlighting the practical applications of this study's findings. Doi: 10.28991/CEJ-2025-011-01-01 Full Text: PDF
Shaking-Table Test on a Multi-Story Continuous Vibration-Control System Employing Pulley Amplification Mechanism
Authors: Majima Ryo , Yamasaki Yasuo , Saito Taiki
Published: January 2025

This study proposes an innovative passive vibration-control system, named the Pulley Damper Multi-story System (PDMAS), which incorporates pulley tackles installed at multiple stories in the successive stories to amplify inter-story displacement. This configuration significantly enhances the energy absorption efficiency of the linked dampers at the middle of the cable by utilizing the cumulatively amplified story displacements via a continuously stretched cable across the entire structure. The proposed system shows notable potential for controlling responses induced by higher vibration modes by customizing the wire installation layout. The aim of this study is to introduce PDMAS and to investigate its seismic-mitigation effectiveness. As a primary investigation of this new system, comparative experimental studies were conducted through shaking-table tests on nine specimens featuring various cable layouts optimized for the first and second structural vibration modes, with or without dampers, under harmonic waves, white-noise waves, and simulated seismic waves. The experimental results demonstrate that the PDMAS effectively accommodates the cumulative amplified story displacement across the structure to match theoretical damper values. Furthermore, the specimens employing PDMAS with a wire layout optimized for the first structural mode reduced both acceleration and displacement by nearly half compared to specimens without PDMAS. Doi: 10.28991/CEJ-2025-011-01-02 Full Text: PDF
A Novel Steel Lazy Wave Riser Configuration for Ultra-Deepwater
Authors: Haoran Chen , Karuppanan Saravanan , Perumal Veeradasan , Ovinis Mark , Lim Frank , Kumar Suria Devi Vijaya
Published: January 2025

A steel lazy wave riser (SLWR) configuration combines buoyancy modules with a traditional steel catenary riser (SCR). The buoyancy section at the riser separates the floater's motion and acts as a damper toward the critical area in the touchdown point, improving the strength and fatigue performance. In ultra-deepwater environments, the substantial payload of risers due to extreme riser length imposes considerable tension and stress, challenging the limits of traditional configurations such as SLWR and SCR. The effective tension, maximum stress, and minimum bend radius at ultra-deep depths of these conventional risers would exceed the allowable limits, leading to potential structural failure. To address these limitations, this study proposes a novel riser configuration, the shaped steel lazy wave riser (SSLWR), specifically for ultra-deepwater conditions. By introducing an additional buoy section, SSLWR effectively reduces the effective tension while ensuring allowable stress distribution across the riser length, enhancing structural reliability and operational feasibility over traditional risers. OrcaFlex, a fully 3D non-linear finite element software widely used in maritime structure analysis, was used to simulate the effective tension, maximum stress, and minimum bend radius of the SCR, SLWR, and SSLWR configurations at 3000 m depth. The SSLWR shows a maximum effective tension that is less than half of that observed in the SCR, and it remains consistently lower than SCR and SLWR, suggesting that SSLWR holds promise as a robust alternative for ultra-deepwater applications. This study offers new insights into how modifying riser shape and buoy placement can effectively balance tension reduction with stress distribution, providing an alternative to traditional riser designs. The SSLWR's specific responses to buoy placements and varying currents expand an understanding of riser performance under varying conditions, guiding future advancements in offshore riser engineering. Doi: 10.28991/CEJ-2025-011-01-03 Full Text: PDF
Assessment for Evaluation of Local Roads Based on Infrastructure Data and Budget Allocation
Authors: Meriana Desi , Subagio Bambang S. , Najid .
Published: January 2025

Technical criteria are one of the determining factors in calculating the technical index amount of the allocation budget for road infrastructure. The technical criteria include pavement deterioration, bridge condition, road performance, local budget allocation for road capital expenditure, allocation of local budget government for routine maintenance of roads, e-monitoring reporting, and SHP map reporting. Evaluation is required to determine the influence of each of these criteria and highlight the importance of comprehensive and continuous data testing to provide an overview of road infrastructure data and budget allocations. This study aims to analyze the influence of each technical criterion based on infrastructure data and the allocation of funding for local road maintenance in Indonesia. Two regression methods, Multiple Linear Regression with Dummy (MLRD) and Binary Logistic Regression (BLR), were used to identify and evaluate each variable and the potential of the resulting criteria. The results show that pavement deterioration (PD) and road performance (RP) are the criteria that significantly influence the assessment of infrastructure data and are the best models. This finding highlights the need for comprehensive data testing to provide an accurate overview of local road infrastructure from the data submitted by local governments to the central government. Doi: 10.28991/CEJ-2025-011-01-04 Full Text: PDF
Assessment of Urban Changes at the Residential Neighbourhood Level Based on Satellite Imageries
Authors: Kadhim Nada , Salih Nabil M.
Published: January 2025

Ongoing urban expansion leads to the steady loss of green spaces. Residential units' gardens and green open spaces are a vital part of city life, contributing considerably to urban green infrastructure and ecological services. However, these areas are diverse, making it difficult to assess their changes over time to take advantage of their benefits and contribution to sustainable urban development. This study proposes a new methodology that combines survey data with high-resolution image analysis to construct maps and statistics of change in two residential neighbourhood areas in the Iraqi city of Baqubah. Three change detection techniques utilising very high-resolution multispectral Pléiades images were used to evaluate the changes: pixel value differencing, band index differencing, and categorical change detection. Then, a unique strategy employing geo-processing processes by the ModelBuilder tool was applied to the evaluation outcomes to assess the changes in a final manner. In addition to survey data that supported the final change detection outcomes, study validation was conducted through field verification, and the mean accuracy was 93%. The final results indicated that open or green spaces decreased over a period of seven years at rates of 24% and 14% of the total of both areas assessed. Policymakers and urban planners see such privately owned land as difficult to affect. However, reducing vegetative cover areas and turning them into impermeable surfaces may result in the areas becoming inefficient in the development of urban sustainability. Our developed method demonstrates the capability of utilising Very High Resolution (VHR) imagery with local survey data to accurately infer changes in urban vegetation within residential neighbourhood regions. Doi: 10.28991/CEJ-2025-011-01-05 Full Text: PDF
Benchmarking Classical and Deep Machine Learning Models for Predicting Hot Mix Asphalt Dynamic Modulus
Authors: Zeiada Waleed , Obaid Lubna , El-Badawy Sherif , Abd El-Hakim Ragaa , Awed Ahmed
Published: January 2025

The dynamic modulus (|E*|) of hot-mix asphalt (HMA) is a crucial mechanistic characteristic essential in defining the strain response of asphalt concrete (AC) mixtures under varying loading rates and temperatures. This paper aims to conduct a comprehensive investigation of classical machine learning (ML) and deep learning (DL) algorithms as applied to the prediction of |E*| and compare their performance with renowned |E*| regression models (Witczak NCHRP 1-37A, Witczak NCHRP 1-40D, and Hirsch). Eight state-of-the-art ML and DL algorithms are attempted with diverse structures, including multiple linear regression (MLR), decision trees (DT), support vector regression (SVR), ensemble trees (ET), Gaussian process regression (GPR), artificial neural networks (ANN), recurrent neural networks (RNN), and convolutional neural networks (CNN). A comprehensive database was assembled, incorporating 50 AC mixtures, of which 25 were from the Kingdom of Saudi Arabia and 25 were from the state of Idaho, USA. This database encompasses an extensive dataset of 3,720 |E*| measurements, associated with thirteen input features representing the proposed AC mixtures’ aggregate gradations, binder characteristics, and volumetric properties. This pioneering study surpasses existing research by examining various algorithms to predict |E*| on the same dataset, applying them with different structures and individual optimization to achieve optimal performance. The developed models are evaluated based on multi-stage assessment criteria, including the accuracy and complexity performance measures and rationality based on a sensitivity analysis. The multi-stage comparative analysis results reveal that the bagging ETs, GPR with exponential kernel, and DT record the highest prediction accuracy; however, only the bagging ETs yield the highest accuracy, lowest training and testing complexity, and rational trends throughout the sensitivity analysis. The research outcome has the potential to provide pavement engineers with advanced tools for predicting |E*| and, therefore, optimizing pavement designs and rehabilitations. Doi: 10.28991/CEJ-2025-011-01-06 Full Text: PDF
Interaction of Life Cycle Assessment (LCA) and BIM in a Construction Project to Reduce the Environmental Footprint
Authors: Osorio-Gómez Cristian C. , Alzate-Buitrago Alejandro , Amariles-López Cristhian C. , Aristizábal-Torres Daniel , Mancilla-Rico Edwin A.
Published: January 2025

The construction sector is experiencing rapid growth in response to the increasing demand for new projects that address societal needs, making it one of the most significant contributors to greenhouse gas emissions. Therefore, it is essential to develop more sustainable and efficient construction processes that reduce the environmental impact in the sector. This study focuses on assessing the environmental footprint of a residential project in Colombia, based on the implementation of Building Information Modeling (BIM) with a sustainability focus. A Life Cycle Assessment (LCA) was performed using the "One Click LCA" software, where the characteristics of the building over a 50-year period were inserted and evaluated. The study determined the building’s environmental impacts and direct pollutant emissions, including global warming (CO2e), acidification (SO2e), eutrophication (PO4e), and ozone depletion (CFC), among others. The results were analyzed by evaluating their magnitude and criticality. One of the main findings was the emission of 1.49E+06 kg of CO2, which directly impacts global warming significantly. This LCA-BIM approach provides a transparent methodology for construction companies in Latin America to implement projects with a lower environmental impact, promoting sustainable practices within the industry. Doi: 10.28991/CEJ-2025-011-01-08 Full Text: PDF
Rethinking the Development of Sino-Russian Border Economic Cooperation Under the New Situation
Authors: Moying Mou
Published: January 2025

Under the current new situation of severe sanctions imposed by the West on Russia and deepening trade
frictions between China and the United States, Sino-Russian border economic cooperation has expanded and developed, with a substantial increase in the volume of inbound and outbound cargo at border ports, accelerated port construction progress, and substantial results in cross-border infrastructure construction. However, an in-depth analysis of the cooperation phenomenon shows that the border economic cooperation between the two sides is still carried out in
the traditional model of commodity trade. Under the current new situation, the strategic cooperation between the two
countries has promoted the expansion of the scale of border economic cooperation between the two sides, but the lack
of deep fit in the development strategy between China's Northeast and Russia's Far East has restricted the further improvement of the level of cooperation. Therefore, it should be considered to promote the deepening of border economic cooperation between the two sides at the national level.
منهج الشيخ الدكتور يوسف القرضاوي في الفتاوي الشرعية
Authors: إبراهيم حسين محمد
Published: January 2025

أهداف البحث: يهدف البحث إلى خدمة تراث الشيخ القرضاوي، لكي تكون هذه الخدمة ضمن مجموعة من البحوث المنهجية للاسترشاد والاستفادة من هذا التراث الثري بالعلوم.
منهج البحث: اتبعت المنهج الوصفي التحليلي باستنتاج معالمِ منهجية الشيخ القرضاوي في مجال الفتوى من خلال كتبه وبحوثه، وإبراز أهم ما كان يعتمد عليه في ذلك من القواعد الأصولية والفقهية والمقاصدية.
النتائج: قد توصلت إلى أن مدار منهجية الشيخ القرضاوي يدور حول «التيسير»، وهو الذي يبرز في أكثر فتاواه، لكنه أبدع في الاستدلال والتأصيل لهذه المنهجية، فلم يتهاون في الأخذ بالنصوص، ولم يتشدد في الاستدلال بها، وحاول قدر الإمكان إيجاد مخارج ميسرة للمسائل المستجدة بوسطية واعتدال. كما توصلت إلى أن الشيخ القرضاوي بنى لنفسه قواعد في الفتوى في غاية الدقة والوضوح، التزم بها في كتبه وفتاويه أشد التزام، وأخيرًا بعد التدقيق والتتبع رأيت أن أكثر الانتقادات على الشيخ القرضاوي غير دقيقة وناشئة عن تعصب مذهبي أو اتجاه سياسي، ومع ذلك فقد وقعت منه هنات وأخطاء في الاجتهادات والفتوى فله أجر المجتهد إن شاء الله.
أصالة البحث: تأتي أصالة البحث في كونه يتناول جانبا مهما من اهتمامات الشيخ القرضاوي ألا وهو «الفتاوي الشرعية»، ویلخص المنهجية والضوابط التي اتبعها الشيخ في ذلك.
فقه التنزيل عند القرضاوي: قراءة تحليليّة للمنطلق والمنهج
Authors: النوري أسماء
Published: January 2025

أهداف البحث: يهدف البحث إلى بيان حضور فقه التنزيل في معالجة قضيّة تطبيق الشّريعة، الّتي تمثّل إحدى القضايا المركزيّة في الدّراسات المعاصرة. وهو ما يستدعي طرح مسألة المنهج في تعامل المعاصرين مع مباحث الاجتهاد، ولعلّ أبرزهم القرضاوي الّذي يختصّ طرحه المعرفي والفقهي بمعالجة شاملة لمسألة المرجعيّة الإسلاميّة، وسبل تطبيق كليّاتها وجزئيّات أحكامها من خلال مسلكَي الترشيد والتجديد في مستوى التّعامل مع النّصوص فقها وتنزيلا.
وحيث يدلّ ذلك على فقه التنزيل تضمّنا، فإنّ محاور هذه الورقة البحثيّة تدور حول حضور هذا الضرب الاجتهادي في رؤية القرضاوي للاجتهاد المعاصر.
منهج الدراسة: يقوم البحث على المنهج الاستقرائي من حيث تتبّع النّصوص ذات الصّلة بالموضوع في الجانب النّظري والتطبيقي. إضافة إلى الاعتماد على المنهج التحليلي للوقوف على المضامين المعرفيّة للمسائل المدروسة.
النتائج: خلص البحث إلى التأكيد على أصالة فقه التنزيل وحضوره المركزي في صياغة القرضاوي لرؤيته للاجتهاد المعاصر. كما بيّن معالم التجديد والترشيد في تنزيل نصوص الأحكام، الّذي يقوم على الربط بين كلّيات الإسلام وجزئيّاته، مقاصده ومعانيه، مراتبه وأولويّاته.
أصالة البحث: تكمن أصالة البحث في تعلّقه المباشر بطرح القرضاوي الشّامل للمرجعيّة الإسلاميّة في الواقع المعاصر، وفي كونه أوّل بحث تناول المباحثة النظريّة والتطبيقيّة لمسائله مع الالتزام بأدوات البحث العلمي الرصين.
A PSYCHOANALYTICAL APPROACH TO PORTNOY’S QUEST FOR HIS JEWISH IDENTITY IN PHILIP ROTH’S PORTNOY’S COMPLAINT
Authors: J. Cijo Christober , Silvest R. S. Regin
Published: January 2025

As a consequence of his unreserved depictions of assimilated Jews discarding traditional norms, Roth became estranged from Jewish authorities and became known as the quintessential outsider. Simultaneously, his work continues to resonate with Jews today and shaped the self-perception of new generations of Americanized Jews. This essay looks at how Roth treats Jewish development in his writing and suggests that his attempts are an argument in favor of a stronger feeling of Jewish uniqueness and defiance of authority—Philip Roth’s Portnoy’s Complaint about the conflict between the self and the outside world. The main character deals with internal, external, and self-versus-world issues. It is revealed that Portnoy has problems with his Jewish friends and family, who serve as a microcosm of the ethnic community he is a member of. He believes, falsely, that his culture is the primary cause of his alienation. He finds it troubling that his sexual enjoyment and his moral values contradict one another. His problems aren’t resolved until the end of the book, even though he starts to realize his moral dilemma. This American novel describes what it’s like to be a Jewish youngster growing up in America. It takes strong action against radical religious beliefs held by American Jewish groups. The Portnoy’s Complaint has a very distinct style. It begins with the traditional first-person point of view and combines it with a modernist mental morality. Roth explores the endless and perhaps unsolvable conflict between man and his basic impulses by entering his species’ primitive mind and illuminating the strange, horrifying, and inexplicable reality of human desires and experiences.
THE LEGAL EFFICACY OF STRATEGIES FOR PROTECTING CULTURAL HERITAGE AND PREVENTING ART CRIMES
Authors: Namita Namita , Shourie Anand Singh
Published: January 2025

Cultural heritage of a country is its identity, and it is unique to a particular group or to that particular community. It surely reflects upon the lifestyle the language and the way of life of that nation. Such is the richness of cultural heritage that it can be tangible like a monument, or an artefact and it can be intangible like the cultural beliefs, the traditions, the rituals, the festivals and the practices of a particular country. The tangible cultural heritage can be immovable like the Taj Mahal of India, the Eiffel Tower of Paris, the Colosseum of Italy, the Stone Henge, Machu Picchu and many others. It is a known fact that cultural heritage of a place shapes a nation, it shapes the society for ages and prepares the future generations to come. The threat to any cultural heritage originates from the conflicting ideas or interest of other groups outside of a particular community, race or a nation. Sometimes the Heritage of a country has natural or manufactured objects which represent the Heritage significance of that time, era, group, race, community or belief. These objects whether natural or manufactured are also apart of cultural heritage.