bluuebunny/crossref_metadata_2025 huggingface dataset:
Phát hiện loài nấm polycephalomyces nipponicus ký sinh trên ấu trùng ve sầu tại thị trấn Ea Knốp, Tỉnh Đăk Lăk, Việt Nam
Authors: Hạnh Trịnh Văn , Thuận Lao Đức , Thúy Lê Huyền Ái , Huệ Thiều Hồng , Lợi Vương , Duy Lê Anh , Nguyên Trương Bình , Hiệp Đinh Minh
Published: March 2023

Mẫu nấm H022, ký sinh trên ấu trùng ve sầu, được phát hiện ở khu vực thị trấn Ea Knốp - Tỉnh Đăk Lăk. Mẫu nấm được thu nhận, đưa về phòng thí nghiệm để giải phẫu hình thái nhằm xác định tên loài. Đồng thời, DNA bộ gene được thu nhận bằng phương pháp phenol/chloroform để tiến hành khuếch đại các gene mục tiêu nrSSU, ITS, nrLSU, Rpb1, Tef1 bằng kỹ thuật PCR. Sản phẩm khuếch đại được giải trình tự và tiến hành phân tích phát sinh loài phân tử để hỗ trợ việc định danh. Kết quả phân tích hình thái khẳng định rằng mẫu H022 chính là loài Polycephalomyces nipponicus (Kobayasi) (Kepler & ctg., 2013). Kết quả phân tích phát sinh loài phân tử cho thấy mẫu H022 hình thành nhóm đơn huyết thống với trình tự loài Polycephalomyces nipponicus với giá trị bootstrap lần lượt là 100/100/100 (Neighbor-Joining (NJ), Maximum Parsimony (MP), and Maximum Likelihood (ML)). Kết quả giải phẫu hình thái và phát sinh loài phân tử đều khẳng định mẫu nấm H022 là loài Polycephalomyces nipponicus (Kobayasi) (Kepler & ctg., 2013). Ngoài ra, đây là ghi nhận đầu tiên loài Polycephalomyces nipponicus tại Đăk Lăk.
Phát triển quy trình sản xuất Trastuzumab trên dòng tế bào buồng trứng chuột Hamster Trung Quốc (CHO) quy mô phòng thí nghiệm
Authors: Huy Nguyễn Quang , My Từ Tiểu , Huy Hứa Hoàng Quốc , An Nguyễn Trường , Phát Hà Tấn , Trang Nguyễn Thị Thùy , Long Đinh Văn , Hùng Trịnh Thanh , Sĩ Đỗ Minh
Published: March 2023

Tế bào CHO đã và đang được sử dụng phổ biến trong sản xuất protein tái tổ hợp. Theo thống kê, khoảng 70% protein tái tổ hợp điều trị cho người được sản xuất trong hệ thống tế bào CHO và doanh thu vượt quá 15 tỷ bảng mỗi năm. Việc khảo sát tối ưu các điều kiện nuôi cấy cho thấy mật độ tế bào cao nhất có thể đạt trên 18 triệu tế bào/ml và nồng độ sản phẩm cuối cùng đạt từ 01 - 05g/L Vì vậy, việc phát triển tối ưu quy trình sản xuất quy mô PTN đóng vai trò khá quan trọng nhằm tìm ra các nghiệm thức tối ưu, áp dụng cho lên men sản xuất Trastuzumab quy mô công nghiệp. Trong nghiên cứu này, dòng tế bào sản xuất Trastuzumab được khảo sát theo từng bước: môi trường nuôi cấy, tỉ lệ phần trăm chất bổ sung, nhiệt độ nuôi cấy và tốc độ lắc. Kết quả nghiên cứu đã tìm ra các điều kiện nuôi cấy tối ưu quy mô PTN như sau: tế bào được nuôi cấy lắc 100rpm trong môi trường ActiPro có bổ sung chất dinh dưỡng Cell Boost 7a/7b (tỉ lệ 1:0.1%) hàng ngày từ ngày 03, nhiệt độ tăng sinh ban đầu là 37oC sau đó hạ xuống 32oC vào ngày thứ 05. Sau 14 ngày nuôi cấy, mật độ tế bào trên 25 triệu tế bào/ml và nồng độ Trastuzumab thu được gần 04g/L.
Chưng cất tinh dầu căn hành gừng Zingiber officinale Roscoe trồng tại Phú Yên và Bình Dương
Authors: Hoàng Nguyễn Minh
Published: March 2023

inh dầu gừng là một trong những tinh dầu quý do có công dụng chữa bệnh buồn nôn, chống say tàu xe, kháng oxi hóa, kháng khuẩn và kháng viêm. Trong nghiên cứu này, thành phần hóa học tinh dầu từ căn hành gừng Zingiber officinale Roscoe trồng tại Phú Yên và Bình Dương lần đầu tiên được công bố. Các thông số chưng cất lôi cuốn hơi nước tối ưu bao gồm thời gian ly trích (06 giờ) và tỉ lệ nguyên liệu: nước (1:3 g/ml). Thành phần hóa học tinh dầu được phân tích bằng phương pháp sắc ký khí ghép khối phổ (GC-MS) cho thấy zingiberene, α-farnesene, geranial, sesquisabinene, neral, camphene, β-bisabolene là các cấu phần chính trong tinh dầu gừng.
Hiện trạng kháng thuốc kháng sinh của một số chủng vi khuẩn gây bệnh phân lập từ cá rô đồng (Anabas testudineus) ở các trang trại trên địa bàn Thành Phố Hồ Chí Minh
Authors: Cường Trần Kiên , Đoan Huỳnh Trần Thục , Dũng Phan Tiến , Luân Nguyễn Thành , Hà Phạm Thị Hải
Published: March 2023

Giới thiệu: Cá rô đồng (Anabas testudineus) hiện đang là đối tượng nuôi có giá trị kinh tế cao, phân bố nhiều quốc gia trong đó có Việt Nam. Việc lạm dụng kháng sinh, hóa chất kháng khuẩn đang gây nhiều tác động tiêu cực tới môi trường cũng như con người.

Vật liệu và phương pháp: Nghiên cứu thu nhận những mẫu cá rô đồng có các dấu hiệu nghi ngờ nhiễm bệnh và tiến hành phân lập khuẩn từ các mẫu cá thu nhận. Vi khuẩn phân lập được kiểm tra đặc tính hình thái, đặc trưng sinh hóa và tiến hành đánh giá tình trạng kháng kháng sinh của chúng bằng phương pháp kháng sinh đồ bằng đĩa giấy tẩm kháng sinh, phương pháp giải trình tự phân tích cây phát sinh loài bằng phần mềm Mega 11, model Kimura-2-parameter bootstrap 1,000 lần được dùng để định danh phân tử bằng gen 16S rRNA.

Kết quả: Nghiên cứu đã phân lập được 14 nhóm vi sinh từ cá rô đồng bệnh/dấu hiệu lạ thu thập từ các trang trại trên địa bàn Thành phố Hồ Chí Minh (TP.HCM). Nghiên cứu tiếp tục định danh 04 chủng vi khuẩn có mức độ tương đồng khi so sánh trình tự gen 16S rRNA lần lượt Pseudomonas aeruginosa (99.77%), Aeromonas dhakensis (99.93%), Kosakonia sacchari (100%), và Edwardsiella ictaluri (99.44%).

Kết luận: Kết quả thu nhận 04 chủng khuẩn giải trình tự có hiện trạng đa kháng kháng sinh trên cá rô đồng A. testudineus đang lưu hành ở TP.HCM.
PRINCIPLES OF GNSS
Authors:   Konstantin Preslavsky University of Shumen, Faculty of Technical Sciences, Bulgaria, Ivanov Sabin
Published: March 2023

The most direct method for obtaining spatial information in digital form is the use of data from Polish geodetic measurements obtained from the global satellite location identification system. Global location systems GNSS belong to non-photographic recording systems of the group of remote methods for Earth measurements. The most popular system is GPS (Global Positioning System), designed and controlled by the US Department of Defense.
ANALYSIS OF GENOTYPE BY ENVIRONMENT INTERACTION FOR SPIKE TRAITS IN WINTER SIX-ROW BARLEY
Authors:   Center for small grains and rural development, Kragujevac, Serbia, Bratković Kamenko , Luković Kristina ,   Center for small grains and rural development, Kragujevac, Serbia, Perišić Vladimir ,   Center for small grains and rural development, Kragujevac, Serbia, Maksimović Jelena ,   Institute for soil science, Serbia, Savić Jasna ,   University of Belgrade, Faculty of Agriculture, Serbia, Đekić Vera ,   Univrsity of Niš, Faculty of Agriculture, Serbia, Matković Stojšin Mirela ,   Institute Tamiš, Serbia
Published: March 2023

This research was conducted with some spike traits of twenty winter six-row barley genotypes in six environments. The aim of this study was to determine the significance and take advantage useful genotype by environment interacton (GEI) by applying AMMI-1 model. High statistical significance GEI was determined. Wide adaptability genotypes were J-29, J-33, J-9 and J-21 for spike length (SL) as Grand and Ozren for grain number per spike (GNS). The winner genotypes in all environments were Ozren and Grand for SL as Ozren for GNS. All the examined environments can be considered as one megaenvironment, which indicates that unpredictable interactions dominate in this research.
CROP WEEDS DETECTION USING NEURAL NETWORK MODELS
Authors:   University of Kragujevac, Faculty of Agronomy, Serbia, Marković Dušan , Pešović Uroš ,   University of Kragujevac, Faculty of Technical Sciences, Serbia, Tomić Dalibor ,   University of Kragujevac, Faculty of Agronomy, Serbia, Stevović Vladeta ,   University of Kragujevac, Faculty of Agronomy, Serbia
Published: March 2023

Weeds are one of the most important factors affecting agricultural production. Environmental pollution caused by the application of herbicides over the entire agricultural land surface is becoming more and more obvious. Accurately distinguishing crops from weeds by machines and achieving precise treatment of only weed species is one possibility to reduce the use of herbicides. However, precise treatment depends on the precise identification and location of weeds and cultivated plants. The aim of the work was to describe and point out the importance of deep learning models for the detection and classification of weeds, in order to enhance their application in real conditions.
SOME ASPECTS OF ELECTROLYTIC-PLASMA PROCESSING TECHNOLOGY
Authors: Tarasov I.K. , Klosovskij A.V. , Taran A.V. , Romaniuk S.P.
Published: March 2023

A technological device (pilot model) for electrolytic-plasma processing of various surfaces has been developed. Some theoretical calculations and processing recommendations have been done. This technology contributes to significant savings in human and energy resources and achieving the required surface quality of parts, and preliminary
processing, and is very usefullbefore vacuum-arc deposition of protective coatings
Classificação de procedimentos médicos na saúde suplementar no Brasil
Authors: Goto Miyuki
Published: March 2023

A evolução da medicina, especialmente no aspecto tecnológico, tem levado à criação de procedimentos médicos que devem ser classificados, agrupados, hierarquizados e valorados. A Classificação Brasileira Hierarquizada de Procedimentos Médicos (CBHPM) é o resultado da evolução e substituição das extintas tabelas de honorários médicos e da lista de procedimentos médicos. A CBHPM precisa, porém, de constante atualização, feita pelas diversas especialidades médicas que executam os seus procedimentos.

Unitermos: Classificação Brasileira Hierarquizada de Procedimentos Médicos; CBHPM; tecnologia em saúde; valoração de procedimentos.
Machine Learning-Based Noise Reduction for Craniofacial Bone Segmentation in CT Images
Authors: Nishimoto Soh
Published: March 2023

Objective: When high X-ray absorption rate materials such as metal prosthetics are in the field of CT scan, noise called metal artifacts might appear. In reconstructing a three-dimensional bone model from X-ray CT images, the metal artifacts remain. Often, the image of the scanning bed also remains. A machine learning-based system to reduce noises in the craniofacial CT images was constructed.

Methods: DICOM images of CT archives of patients with head and neck tumors were used. The metal artifacts and beds were removed from the threshold segmented images to obtain the target bony images. U-nets, respectively with the function loss of mean squared error, Dice and Jaccard, were trained by the datasets consisting of 5671 DICOM images and corresponding target images. DICOM images of 2000 validation datasets were given to the trained models and predicted images were obtained.

Results: The use of mean squared errors presented superiority to Dice or Jaccard loss. The mean prediction error pixels were 14.43, 778.57, and 757.60 respectively per 512 x 512 pixeled image.

Conclusion: Automatic CT image noise reduction system was constructed. Dedicated to the delineation of craniofacial bones, the presented study showed high prediction accuracy. The “correctness” of the predictions made by this system may not be guaranteed, but the results were generally satisfactory.
Repair of Bowel Perforation: Endoscopic State of the Art
Authors: Wheeler Matthew B
Published: March 2023

Background: Intestinal damage from various etiologies can result in the potentially dangerous complication of bowel perforation. Emergent treatment of small bowel perforation includes surgical repair with or without small bowel resection. As the number of therapeutic and diagnostic endoscopic procedures increase, more studies may be required to properly evaluate and report incidences of bowel perforation. Given the advantages of interventional procedures, novel endoscopic technologies which may prove beneficial in bowel perforation repair are continuously undergoing development.

Bowel perforation can lead to peritonitis and sepsis – a medical emergency requiring immediate attention. Following diagnosis, hemodynamically stable patients may be treated conservatively whereas unstable patients undergo more intensive surgical procedures. Endoscopic procedures for bowel perforation repair also exist and recent advances in technology are furthering the scope of such closure methods.

Methods and Findings: Endoscopic suturing technologies, while capable, require extensive training and entail prolonged activation processes. Wound vacuum sponge closure via endoscopy provides convergence of wound defects but may not be efficacious in defects larger than 5 cm. Furthermore, this method may be limited by inadequate seal and placement in the intestine. Endoscopic clipping is another modality beneficial for smaller perforations only. T-tag suturing has shown promising results in ex-vivo studies but entails blind placement of T-tags for perforation closure. Stents can be inserted endoscopically under fluoroscopic visual guidance. This technique, however, may result in stent migration, perforations and potential occlusions. Sealants can be injected for perforation closure but have not demonstrated clear efficacy. Robotic flexible endoscopy provides several novel features yet may require advanced training and sometimes more than one operator.

As interventional procedures continue to gain popularity, a better understanding of endoscopic modalities is helpful for furthering their development. Regarding bowel perforation, this review aids in an overall understanding of the technologies which exist and are advancing further into more standard modalities for practical medical applications.

Conclusion: There are currently various methods to repair perforation of the gastrointestinal wall and except for urgent exploratory laparotomy when indicated, there is likely no single method that is superior to others. It may be beneficial for the physician to consider all options for repair when evaluating a potential bowel perforation, considering physician preference and individual success or difficulty with a given modality. In more recent years as the focus has narrowed on minimally invasive procedures, future modalities will likely include increased automation and ease of use with the help of robotics, which will hopefully lead to decreased time to diagnosis, faster recovery and reduced morbidity and mortality.
Methodological Aspects of Traditional Chinese Medicine (TCM)
Authors: Ernst Edzard
Published: March 2023

The efficacy of Traditional Chinese Medicine (TCM) is less well-established than many believe and needs to be more firmly established through clinical trials. Such studies should adhere to the currently accepted standards. When planning and conducting clinical trials, one encounters numerous logistical and methodological problems. The most important logistical obstacle is a lack of funds while the most important methodological issue is to transparently minimise bias. Despite these formidable problems, clinical trials of TCM are usually feasible and certainly necessary for testing the efficacy of TCM.

Key words: Acupuncture, Clinical trial, Herbal medicine
Comparison of Chinese Medicine Education and Training in China and Australia
Authors: Xue Charlie Changli , Wu Qing , Zhou Wen Yu , Yang Wei Hong , Story David Frederick
Published: March 2023

The similarities and differences between Chinese medicine (CM) education in China and Australia are considered in a detailed comparison of the five-year undergraduate programmes offered by the Beijing University of CM (BUCM), China and RMIT University (RMIT), Australia. BUCM is a specialist CM institution whereas RMIT is a technological university providing training in a wide range of professional areas. Both institutions are considered to be leading tertiary institutions within their respective countries. A brief account of the historical development of CM education in China and Australia is provided. We have compared the curricula and structure of the programmes and how they each address the development of essential graduate capabilities for competent and safe clinical CM practice. We have also considered the quality assurance processes and the requirements of external regulatory authorities. The curricula and educational objectives of the 2 programmes are broadly similar. Both institutions have established rigorous processes for managing teaching quality and ensuring appropriate graduates to promote evidence-based CM practice. However, there are differences relating to the healthcare systems of China and Australia and to the availability of teaching resources and clinical training facilities such as classical CM texts and CM hospitals. These differences present major challenges for the internationalisation of CM education. The findings of this study may facilitate the process of CM curriculum development in a global context.

Key words: Chinese medicine curricula, Chinese medicine education and training, Graduate capabilities, Higher education
Presumed Dapsone-induced Drug Hypersensitivity Syndrome Causing Reversible Hypersensitivity Myocarditis and Thyrotoxicosis
Authors: Teo Rachael YL , Tay Yong-Kwang , Tan Chong-Hiok , Ng Victor , Oh Daniel CT
Published: March 2023

Introduction: A 22-year-old Malay soldier developed dapsone hypersensitivity syndrome 12 weeks after taking maloprim (dapsone 100 mg/pyrimethamine 12.5 mg) for anti-malarial prophylaxis. Clinical Picture: He presented with fever, rash, lymphadenopathy and multiple organ involvement including serositis, hepatitis and thyroiditis. Subsequently, he developed congestive heart failure with a reduction in ejection fraction on echocardiogram, and serum cardiac enzyme elevation consistent with a hypersensitivity myocarditis. Treatment: Maloprim was discontinued and he was treated with steroids, diuretics and an angiotensin-converting-enzyme inhibitor. Outcome: He has made a complete recovery with resolution of thyroiditis and a return to normal ejection fraction 10 months after admission. Conclusion: In summary, we report a case of dapsone hypersensitivity syndrome with classical symptoms of fever, rash and multi-organ involvement including a rare manifestation of myocarditis. To our knowledge, this is the first case of dapsone-related hypersensitivity myocarditis not diagnosed in a post-mortem setting. As maloprim is widely used for malaria prophylaxis, clinicians need to be aware of this unusual but potentially serious association. Key words: Anti-malarial, Exanthema, Myocardium, Thyroiditis
Neisseria meningitidis Keratitis in Adults: A Case Series
Authors: Tan Colin SH , Krishnan Prabha U , Foo Fong Yee , Pan James CH , Voon Li Wern
Published: March 2023

Introduction: The aim of this case series is to describe the clinical course of 2 patients with Neisseria meningitidis corneal ulcers.

Clinical Picture: A 49-year-old man (Patient 1) and a 22- year-old man (Patient 2) both experienced eye pain and were found to have corneal ulcers with surrounding infiltrate and ground-glass appearance. Gram-negative diplococci were seen in the first case. N. meningitidis was isolated in culture of corneal scrapings from both patients.
Treatment: Patient 1 was treated with levofloxacin (0.5%) and cefazolin (50 mg/mL) eye drops hourly and intravenous ceftriaxone and oral rifampicin. Patient 2 was treated with cefazolin (50 mg/mL) and gentamicin (14 mg/mL) eye drops hourly, as well as intravenous ceftriaxone.
Outcome: The corneal ulcers resolved with anterior stromal scarring and no impairment of vision.
Conclusions: Corneal ulcers caused by N. meningitidis may respond well to treatment without permanent visual sequelae. However, in view of the potential ocular and systemic complications, it is important to investigate and treat patients with N. meningitidis infection aggressively.

Key words: Bacterial, Corneal ulcer, Eye infections
Image-guided Radiofrequency Ablation of Liver Malignancies: Experience at Singapore General Hospital
Authors: Low Shoen CS , Lo Richard HG , Lau Te-Neng , Ooi London Lucien PJ , Ho Chee-Keong , Tan Bien-Soo , Chung Alexander YF , Koo Wen-Hsin , Chow Pierce KH
Published: March 2023

Introduction: The aim of this paper was to study the efficacy, side effects and complications of radiofrequency (RF) ablation of primary and metastatic liver malignancies.

Materials and Methods: We retrospectively reviewed 57 patients (39 men, 18 women; mean age, 63 years; age range, 44 to 83 years) who underwent RF ablation for liver malignancies from January 2002 to December 2004. A total of 87 tumours were ablated – 71 (81.6%) hepatocellular carcinomas and 16 (18.4%) metastases (from primaries in the colon, stomach and pancreas). RF ablation was performed either percutaneously (n = 71) under conscious sedation or intraoperatively (n = 16) under general anaesthesia. Follow-up ranged from 1 month to 41 months (mean, 15.2) and included computed tomography (CT) 1 day, 1 month and 3 months after ablation, and half-yearly thereafter. Patients were observed for local tumour progression and for the emergence of new tumours.
Results: Four patients with a total of 5 tumours were lost to follow-up. Of the remaining 82 tumours treated, complete ablation was attained in 66 tumours after a single procedure, giving a primary effectiveness rate of 80.5%. Seven (8.5%) required 2 procedures to achieve complete ablation, giving a secondary effectiveness rate of 89% after 2 ablations. One tumour (1.2%) required 3 procedures to achieve complete ablation. One tumour required 4 procedures to date, with the latest follow-up CT still demonstrating incomplete ablation. Two tumours (2.4%) had an initial RF ablation and subsequent transarterial chemoembolisation (TACE). One tumour had an initial RF ablation followed by 32Phosphorus-biosilicon (BrachySil®) injection, the latter as part of a Phase IIA trial. One tumour required 2 RF ablations and a subsequent TACE. Lastly, 3 tumours received initial RF ablation but subsequent local tumour progression was not treated as the patients were deemed unfit for repeat ablation. No procedure-related deaths or major complications were encountered. Minor complications were reported in 2 patients (3.8%) – subcapsular haematoma and thermal injury to the adjacent gastric antrum, both not necessitating surgical intervention.
Conclusions: RF ablation is an effective, safe and relatively simple procedure for the treatment of unresectable liver malignancies.

Key words: Hepatocellular carcinoma, Liver neoplasms, Radiofrequency ablation, Therapeutic chemoembolisation
Use of D-dimer and Lower Extremity Doppler Ultrasound Results to Obviate the Need for Computerised Tomographic Pulmonary Angiography
Authors: Mukhopadhyay Amartya , Venkatesh Sudhakar , Goh Poh Sun , Lim Tow Keang
Published: March 2023

Introduction: We hypothesise that correct interpretation of other diagnostic tests could reduce the use of computerised tomographic pulmonary angiogram (CTPA) examinations in patients with suspected pulmonary embolism (PE).

Materials and Methods: We carried out a retrospective analysis of 158 patients in a 928-bed university hospital. These consecutive patients were investigated for suspected PE from May 2001 to February 2002 using CTPA.
Results: There were 74 men and 84 women with a mean (±SD) age of 57 (±19) years. Overall, 56% of patients (89/158) showed clinically significant abnormalities on the CTPA examination. The overall prevalence of PE was 15% (24/158). The D-dimers were assayed in 40% (63/158) and lower limbs were scanned with Doppler ultrasound (US) in 22% (35/158) of patients. None of the 19 patients with negative D-dimer assays had PE. Of the patients who were positively tested on Doppler US, 4 were positive and 1 was negative for PE on the CTPA. None of the patients with positive Doppler US had negative D-dimer test. In retrospect, patient management based on negative D-dimer assays and positive lower extremity Doppler US studies could have reduced the need for further investigation with CTPA by 15% (24/158).
Conclusion: In patients with suspected PE, correct interpretation of D-dimer and leg Doppler US tests may reduce the demand for CTPAs.

Key words: CTPA, D-dimer, Doppler ultrasound, Spiral CT
Electrophysiological Findings in Persons With Nyctalopia
Authors: Chia Audrey , Luu Chi D
Published: March 2023

Introduction: Ophthalmologists are occasionally confronted with an individual presenting with nyctalopia (i.e., a relatively greater difficulty seeing at night). When there is no accompanying abnormality seen in the fundus, visual electrophysiology becomes useful as an objective means of assessing rod (scotopic) photoreceptor function or pathway defects.

Materials and Methods: A retrospective study was performed on 50 consecutive patients, aged less than 40 years, with seemingly normal fundi and good vision [visual acuity (VA) >6/12] presenting to the Visual Electrodiagnostic Unit, Singapore National Eye Centre, for the investigation of nyctalopia over a 2-year period. Subjective scotopic threshold sensitivity (STS) and objective full-field electroretinogram (ERG) were performed. Persons with abnormal test results were identified.
Results: Normal ERG scotopic responses were obtained in 74% of subjects. There was no significant difference in age, refraction and STS levels between subjects with abnormal and normal ERG. In the group with abnormal scotopic ERG responses, 9 were identified to have non-specific rod dysfunction, 2 had rod-cone dystrophies and 2 had ERG changes suggestive of congenital stationary night blindness (CSNB).
Conclusion: A large number of subjects presenting with nyctalopia had normal ERG findings. We can only assume that in these patients, no significant rod pathway dysfunction exists and that optical (e.g., night or instrument myopia) and psychological aetiologies should be considered. The fact that an abnormal result occurs in 26%, however, suggests that ncytalopia should be evaluated with electrophysiolgoical testing even when the fundi appear normal.

Key words: Electroretinogram, Night blindness, Nyctalopia
Clinical Report: A Case of Williams Syndrome and Klinefelter Syndrome
Authors: Lee Le Ye , Quek Swee Chye , Chong Samuel S , Tan Arnold SC , Lum Josephine MS , Goh Denise Li-Meng
Published: March 2023

Introduction: Williams syndrome (WS) is a rare but well recognised neurodevelopmental disease affecting the connective tissue and the central nervous system. Many patients are identified through the presence of dysmorphic features and associated cardiac abnormalities. Klinefelter syndrome (KS) is associated with gynaecomastia, small testes, azoospermia and elevated gonadotropin levels. They are recognised in the second decade of life by their tall stature and delay in pubertal development. A combination of constitutive WS and KS has yet to be described.

Clinical Picture: We report a child with these genetic aberrations, highlighting the clinical characteristics of such an individual.
Conclusion: The manifestations and interactions of both conditions are also discussed.

Key words: Adrenocortical hyperfunction, Cushing’s syndrome, Nodular adrenocortical disease
Effect of Theraband Exercises on Neck Pain and Forward Head Posture in Various Occupation
Authors:   HOD, Department of Physiotherapy DIBMS, Dehradun, Deepti Warikoo , Shikha Sharma ,   Researcher DBIMS, Dehradun, Mahanta Sushil Kumar ,   Researcher DBIMS, Dehradun, Kumar Ashish ,   Researcher DBIMS, Dehradun, Kumari Vanshika ,   Researcher DBIMS, Dehradun
Published: March 2023

Introduction: Various occupation experience daily neck pain largely due to their awkward postures and high work demand. This puts extra strain on the muscles and predispose to development of faulty posture and muscles imbalance. So to avoid all this problems and exercise plan is needed, which can be easily performed even at the workplace. The purpose of the study was to determine the effects of the band exercises on neck pain and forward head posture in various occupation. Methodology: Thirty patients between the age of 25-50 participated in the study. They were randomly assigned to either and experimental (15) or a control group (15). The experiment group participated in Thera Band exercises Programme while control performed conventional exercises for 6 weeks. Evaluation of neck pain done by numeric pain rating scale and forward head posture was measured by digital photography technique. Results: The paired sample t-test results showed statistically significant difference in the pre and post intervention scores of both NPRS (p=<0.01) and CV angle (p=<0.01) in the participants of both the groups. Conclusion: the result of this study suggests that the use of TheraBand exercises may be helpful for reducing neck pain and carting forward head posture in various occupation. Methods: An comparative study was conducted on 30 patients having neck pain and forward head posture in various physiotherapy OPD and rehabilitation Centre Dehradun. The patient neck pain was measured by NPRS (Numeric Pain Rating Scale) and forward head posture measured by the digital photography technique. Results: The majority of patient was showing significant reduction in neck pain and extent of forward head Posture. Conclusion: The result of this study suggests that the use of Thera Band exercises maybe helpful for reducing neck pain and correction forward head posture in various occupation.
The Effect of Compensation and Career Development on Engagement and Loyalty Employees in the Production Department Pt Paiton Operation Maintenance Indonesia Probolinggo
Authors:   Universitas 17 Agustus 1945 Surabaya, Indonesia, Rahman Zulfikar , Brahmasari I. A. ,   Universitas 17 Agustus 1945 Surabaya, Indonesia, Ratih I. A. Brahma ,   Universitas 17 Agustus 1945 Surabaya, Indonesia
Published: March 2023

Human resources are driving assets that need to be managed and developed professionally because every organization or company wants human resources who are experts in their field, highly dedicated, have loyalty and are attached to the company. The purpose of this research is to find out whether compensation and career development significantly affect employee engagement and loyalty. The population in this study are employees of PT. Paiton Operation Maintenance Indonesia in Probolinggo. The sampling technique was simple random sampling of 109 respondents. The research results and hypotheses show that simultaneously and partially compensation and career development significantly affect employee engagement and loyalty, the leaders at PT. Paiton Operation Maintenance Indonesia, must pay attention to compensation and career development for optimal results in achieving organizational goals.
Trabalho Infantil no Brasil: legado entre gerações e suas consequências sobre a pobreza
Authors:   , Santos Isabela Almeida dos
Published: March 2023

O trabalho infantil é um fenômeno complexo, cujas consequências ultrapassam as noções de defesa e de garantia dos direitos das crianças, adentrando nas questões socioeconômicas. Considerando esta realidade, o presente trabalho tem como objetivo analisar os fatores que se associam à entrada precoce das crianças e adolescentes no mercado de trabalho no Brasil, com ênfase, no efeito do status de trabalhador infantil dos pais sobre este fenômeno, observando se as chances de trabalho infantil se alteram quando apenas a mãe, apenas o pai ou ambos trabalharam quando crianças. Ademais, buscou-se, ainda, verificar se a condição passada de trabalhador infantil dos pais afeta a condição socioeconômica presente dos domicílios. As evidências empíricas foram obtidas a partir do uso de microdados da Pesquisa Nacional por Amostra de Domicílios (PNAD) de 2015, estimadas por meio do Modelo de Probabilidade Linear. Os resultados indicam que o fato de os pais terem exercido trabalho infantil durante a infância aumenta a probabilidade de que seus filhos também exerçam, ou seja, revelam a possibilidade de transmissão de status sociais entre gerações. Além disso, ao se comparar a influência da oferta de trabalho infantil da mãe e a do pai sobre esse fenômeno, verifica-se que a condição do pai é mais influente. Verificou-se ainda que essa probabilidade aumenta, para crianças e adolescentes em que ambos os pais foram trabalhadores infantis, evidenciando o impacto das características sociais dos pais sobre as condições de seus filhos. No que se refere ao efeito da condição passada de trabalhadora infantil da mãe, do pai e de ambos sobre a condição de pobreza do domicilio, observa-se que o status de trabalhador infantil afeta positivamente a possibilidade dos domicílios se encontrarem abaixo da linha da pobreza, o que pode estar diretamente associado às perdas sociais e educacionais ao longo do tempo, que acabam por influenciar as condições futuras. Assim, à medida que esse trabalho verifica que o trabalho infantil é um problema social de longo prazo com efeitos na geração presente e futura, seus resultados possibilita a formatação de políticas públicas para prevenção e erradicação do trabalho infantil e pobreza no Brasil. Palavras-chave: Trabalho Infantil. Pobreza. Transmissão Intergeracional
Desigualdades raciais e de gênero no mercado de trabalho durante a pandemia de COVID-19: uma análise para o Brasil
Authors:   , Tavares Mateus Rodrigues Gonçalves
Published: March 2023

A pandemia causou uma crise econômica, sanitária e social no mundo inteiro, influenciando as pessoas de diferentes maneiras. Este trabalho analisou, utilizando dados de 2020 do Brasil, as probabilidades relativas de mulheres brancas, mulheres negras e homens negros estarem desempregado(a)s, no setor informal e contarem com parte da renda familiar advinda do Auxílio Emergencial durante a pandemia COVID-19. Para tal, foi utilizada uma única cross- section repetida advinda de dados da PNAD COVID19 (dados novos e ricos em informações sobre esse período). O modelo escolhido para a análise foi o Modelo de Probabilidade Linear. Os resultados encontrados apontam que as mulheres negras foram as pessoas mais prováveis de estarem desocupadas ao longo de 2020. Também são prováveis de estarem na informalidade e as mais prováveis de contarem com parte da renda familiar advinda Auxílio Emergencial. Palavras-chave: Mercado de trabalho. Desigualdade. COVID-19
Análise experimental de conexões parafusadas para vigas mistas de aço e madeira
Authors:   , Emerick Jean Antônio
Published: March 2023

Os sistemas de piso seco em Light Steel Framing (LSF) geralmente consistem em placas de madeira conectadas a perfis de aço formados a frio por parafusos autoatarraxantes. Para desenvolver o uso de sistemas de piso seco em LSF e tirar proveito de suas vantagens construtivas, é preciso avançar na compreensão do comportamento estrutural desses sistemas. Pesquisas anteriores mostraram que o comportamento misto entre perfis de aço formados a frio e placas de madeira pode ser obtido, reduzindo o consumo de aço e permitindo maiores vãos. Nesse contexto, esta dissertação trata da análise experimental de conexões parafusadas para vigas mistas de aço formado a frio e madeira. A presente pesquisa abrangeu o estudo do comportamento força/deslizamento das conexões a partir da realização de ensaios push-out, a avaliação da influência de parâmetros que afetam a capacidade resistente, o fluxo de cisalhamento longitudinal, a rigidez e a ductilidade da conexão, a avaliação dos modos de falha. Para isso, realizou-se um programa experimental composto por 30 ensaios push-out, divididos em 6 modelos experimentais. Em cada modelo variou-se o diâmetro dos parafusos e o espaçamento entre eles, e em uma amostra de cada modelo os parafusos foram instalados com arruelas de aço. Os resultados obtidos indicaram que o diâmetro do parafuso influencia a capacidade resistente da conexão. Os resultados indicaram também que o espaçamento entre parafusos influencia o fluxo de cisalhamento longitudinal da conexão, de modo que quanto maior o espaçamento entre parafusos menor o fluxo de cisalhamento longitudinal. As amostras com arruelas de aço não contribuíram no aumento da capacidade resistente e da rigidez dos modelos experimentais. O modo de falha observado para os modelos ensaiados decorreu do esmagamento da placa de Oriented Stranded Board (OSB) associado ao giro do parafuso autoatarraxante. Com base em expressões analíticas relacionadas aos modos de falha, um modelo semiempírico é proposto para predizer a força resistente máxima da conexão entre perfis de aço formados a frio e placas de madeira. Palavras-chave: Análise experimental. Conexão parafusada. Light Steel Framing. Madeira. Viga mista. Perfis formados a frio. Push-out.
Proposição de parâmetros de projeto e dimensionamento para unidades de triagem e compostagem com base em critérios de sustentabilidade e saúde ambiental
Authors:   , Ganem João Lucas Lima Aquino
Published: March 2023

Inúmeros impactos ambientais e à saúde pública são causados pelo manejo inadequado de resíduos sólidos. Não somente às áreas em que se acumulam resíduos de forma inadequada, como também a população no entorno é afetada, poluindo-se o solo, ar e água. No Brasil implementaram-se diversas políticas públicas que almejavam o fim dos lixões, cabendo destaque o programa Minas Sem Lixões em 2003 no Estado de Minas Gerais, a Política Nacional dos Resíduos Sólidos no ano de 2010 com o estabelecimento de metas de encerramento destes. Porém, percebe-se que a disposição inadequada em lixões ou aterros controlados ainda são métodos bastante utilizados no território nacional (39,8%). Popularizadas na década de 90 as Unidades de Triagem e Compostagem (UTC) são percussores do tratamento de resíduos sólidos no Brasil, que visam a redução dos resíduos aterrados com a recuperação da matéria orgânica e do material reciclável, e também a geração de empregos. Entretanto, não obtiveram eficiência esperada, observando-se um grande encerramento das atividades das UTCs. Às margens de um sub emprego com gestão inadequada os triadores ficam à mercê de uma política digna com baixos os salários e pouca percepção sobre os altos riscos laborais aos quais estão expostos, operando em unidades defasadas e mal conservadas ou com erros de concepção. Dos 41 municípios associados ao Cimvalpi, 15 não possuem UTC, em 8 estão desativadas, 9 possuem UTC em funcionamento e 7 em são apenas unidades de triagem em funcionamento, sem compostagem. Obtiveram-se parâmetros mínimos que buscam a eficiência da operação das UTC, respeitando critérios para a saúde ocupacional. Dessa forma, dimensionou-se 3 unidades padrões para diferentes capacidades de processamento de resíduos, apresentando-se layout básicos para poderem ser implementados de acordo com o porte do município. Palavras-chave: Unidades de Triagem e Compostagem. Riscos Ocupacionais. Exposição. Resíduos Sólidos. Lixões. Aterros sanitários. Tratamento de resíduos sólidos urbanos.
Pushover Analysis of Multi-Story Reinforced Concrete Frame Structure
Authors:   M.Sc. Civil Engineering Student, Near East University, Nicosia / TRNC Mersin 10 - Turkey, Hassan Ahmed Abdi , Yasin Ahmed Adan ,   M.Sc. Civil Engineering Student, Near East University, Nicosia / TRNC Mersin 10 - Turkey
Published: March 2023

Pushover analysis is a non-linear static procedure (NSP) used to examine the structural response of a building during the inelastic limit before it reaches the edge of partial or total collapse. In this study a model of multi-story reinforced concrete building along with applied loads is analyzed in powerful non-linear static procedure using computer software ETABS. A limited number of horizontal forces are then applied to imitate the impact of ground movement. The building is supposed as a 6-story building, no shear walls used in the model as the level of earthquake hazard assumed very low. Moreover, deformations are determined. The forces would then be increased gradually, NSPs convert multi-degree of freedom models to single-degree of freedom models utilizing a pushover analysis to determine capacity curve or pushover curve which is horizontal roof displacement vs base shear, This curve plot reveals the highest base motion that the structure can withstand, and then estimate the maximum global displacement by combining a ground response spectrum with the capacity curve.
Special Issue
Authors: Boylan Colin
Published: March 2023

As SPERA celebrates its 25th year as the national organisation whose voice on rural and remote education and training in Australia, the Executive determined mark this historical milestone with a number of significant events. The 2009 annual national conference with its theme Education in a Digital Present: Enriching Rural Communities continues to explore innovative and creative ways of providing education to students located in rural and remote places. During the 25th Conference, the roles, purposes and impacts of digital information technologies will be explored as they transform the way we work, learn and communicate. In this digital revolution, educators, parents and systems are engaged in a comprehensive search for strategies and tools for effective online/digital teaching based on the principles of learning as a social process and engaging the advantages of new technologies to support e-learning decision-making, instructional choices, program and course planning and the delivery of curricula.
FEATURES OF THE DYNAMICS OF EROSION PLUMES AT THE ACTING OF INTENSIVE NANOSECOND LASER PULSES ON A GRAPHITE TARGET IN VACUUM
Authors: Goncharov V. K. , Puzyrev M. V. , Stupakevich V. Yu.
Published: March 2023

The temporal characteristics of the glow intensity of erosion laser plumes near the surface under the action of nanosecond laser pulses on a carbon target are experimentally studied. The interaction of laser radiation with the destruction products of plume is minimal due to the formation of erosion plasma with a delay relative to the acting laser pulse. Using a modernized spectrometer, the spectral characteristics of an erosion

laser plume near the surface of a carbon target with a time resolution of 10–8 s are studied, and the characteristic plasmodynamic times in the plume are ~10–6 s. It is shown that the emission of spectral lines of carbon appears with a delay relative to the glow of the continuous background, when the erosion plume is cooled during expansion. The results of the study make it possible to optimize some characteristics of the laser-

plasma source for the deposition of nanocoatings.
SECOND-HARMONIC GENERATION IN A THIN SPHERICAL LAYER OF A SMALL RADIUS BY COHERENT SOURCES OF ELLIPTICALLY POLARIZED RADIATION
Authors: Talkachov A. I. , Shamyna A. A. , Kapshai V. N.
Published: March 2023

Explicit forms of the power density and the total radiation power of the second-harmonic generation in a thin spherical layer of a small radius are determined. The conditions for a maximal total power of the second harmonic and the direction of observation of the maximum intensity of the second harmonic are found analytically for special cases of the second-order dielectric susceptibility tensor. A numerical maximization of the energy characteristics of the second-harmonic generated radiation is carried out using one and two coherent sources with the same ellipticity of radiation. The advantage of using several coherent sources compared to a single source of initial radiation is shown.
LONGITUDINAL RELAXATION OF NUCLEAR MAGNETIZATION IN RUBBER SOLUTIONS: POLYISOPRENE PROTONS
Authors: Makhiyanov N. , Efimov S. V.
Published: March 2023

The longitudinal (spin-lattice) relaxation times of Т1 of protons are measured selectively (for various structural groups) at a nuclear magnetic resonance frequency of 700 MHz in a solution of an industrial sample of Cariflex-IR0307 isoprene rubber in deuterated benzene. It is shown that the value of T1 significantly

depends on the structural position in the polyisoprene chain. The highest values of T1 are obtained at double bonds of monomer units in the cis-configuration and the methyl group of the trans-unit, the smallest values were obtained for the methine and methylene protons of the 3,4-unit, with a difference of two to three times. The questions of measurement accuracy are considered. Practical recommendations are formulated for the conditions of recording high-resolution NMR1H spectra at quantitative analysis of the structure of isoprene rubbers.
ANALYSIS OF HUMAN HAIR BY THE LASER-INDUCED BREAKDOWN SPECTROSCOPY
Authors: Mayor A. Yu. , Golik S. S. , Borovskiy A. V. , Lisitsa V. V. , Babiy М. Yu. , Ankushev А. S.
Published: March 2023

We experimentally studied the spectral characteristics of plasma generated on the surface of human hair under various focusing conditions (by the lenses with a focal length of 50, 100, 150 mm) by short (9 ns) laser pulses with an energy from 5 to 50 mJ in the regime of elemental composition analysis along the length of the samples. The minimal energetic levels of laser pulses were obtained. The optimal conditions for the registration of the emission lines of magnesium and calcium in the studied samples were determined.
POLARIZATION FEATURES OF ANISOTROPIC BRAGG LIGHT DIFFRACTION ON TRANSMISSIVE HOLOGRAPHIC PHASE GRATINGS
Authors: Kulak G. V. , Naunyka V. N. , Nikolaenko T. V.
Published: March 2023

We established that for anisotropic Bragg light diffraction on holographic phase gratings for significant perturbation amplitudes of the refractive index of the medium, in the transmitted diffraction orders there is a significant rotation of the polarization plane of the diffracted wave, which is absent in the reflected diffraction orders. It is shown that periodic changes in the transmission coefficients of diffracted waves with a change in the azimuth of polarization of incident light are due to a significant difference in the Fresnel reflection coefficients at the layer boundaries for s- and p-components of incident light; these periodic changes are absent in the reflected diffraction orders.
ROLE OF AXIONS IN THE FORMATION OF FREQUENCY AND ANGULAR SPECTRA OF LASER RADIATION PROPAGATING IN A DISPERSIVE MEDIUM
Authors: Ogluzdin V. E.
Published: March 2023

A variant of the interpretation of the spectrum broadening and the change in the angular characteristics of the light beam at the exit of the dispersive medium is proposed. The role of axions responsible for changes in the spectral and angular characteristics of a light beam is considered.
Pilot implementation of speech recognition technology in the endoscopic centers of Moscow Healthcare Department
Authors: Shabunin Alexey V. , Bedin Vladimir V. , Korzheva Irina Yu. , Orlov Stanislav Yu. , Osmak Ekaterina K. , Vasiliev Ilya V. , Nesterov Dmitriy V. , Alepko Alexey A.
Published: March 2023

The endoscopic centers (EC) are faced with intensive overload due to the high patient flows, and the solution might be to implement into routine practice the speech-to-text software for inputting endoscopic examination descriptions. The authors assessed the changes in the time of paper work when endoscopists used speech recognition software, modern wireless headset, available Health Information System, algorithms and standardized protocols. Endoscopists were able to fill in the examination protocols using the developed method of speech recognition based on artificial intelligence (AI) and Voice2Med software. AI-based assessment shows that the absolute majority of professional terminology from the endoscopists' speech was reproduced (the recognition error was less than 3%). Moreover, 100% of endoscopists were satisfied with the voice input technology for making protocols. The study demonstrated that the protocols of endoscopic examinations developed as the result of the project allow endoscopists to reduce the time for writing medical reports as well as the overall time of procedure.
For citation: Shabunin AV, Bedin VV, Korzheva IYu, Orlov SYu, Osmak EK, Vasiliev IV, Nesterov DV, Alepko AA. Pilot implementation of speech recognition technology in the endoscopic centers of Moscow Healthcare Department. City Healthсare. 2023;4(1): 68-74 doi: 10.47619/2713-2617.zm.2023.v.4i1;68-74.