bluuebunny/crossref_metadata_2025 huggingface dataset:
Hormesis in the Assessment of Toxicity Assessment by Luminescent Bacterial Methods
Authors: Si Haoyu , Zhou Guoquan , Luo Yu , Wang Zhuoxuan , Pan Xuejun , Dao Guohua
Published: August 2024

The threat posed by water pollutants to aquatic ecosystems and human health cannot be overlooked, and the assessment of the toxicity of these contaminants is paramount to understanding their risks and formulating effective control measures. Luminescent bacteria-based assays, as a vital tool in evaluating contaminant toxicity, encounter a challenge in ensuring accuracy due to the phenomenon of “Hormesis” exhibited by pollutants towards biological entities, which may skew toxicity assessments. This study elucidated the specific effects of pollutants on luminescent bacteria at different concentrations, used modeling to characterize the effects and predict their toxicity trends, and explored the applicable concentration ranges for different pollutants. Research revealed that six typical pollutants, namely PAHs, endocrine disruptors, antibiotics, pesticides, heavy metals, and phytosensory substances, could promote the luminescence intensity of luminescent bacteria at low concentrations, and the promotional effect increased and then decreased. However, when the concentration of the substances reached a certain threshold, the effect changed from promotional to inhibitory, and the rate of inhibition was directly proportional to the concentration. The EC50 values of six types of substances to luminescent bacteria is as follows: endocrine disruptors > pesticides > antibiotics > heavy metals > polycyclic aromatic hydrocarbons > chemosensory agents. The effect curves were further fitted using the model to analyze the maximum point of the promotion of luminescence intensity by different substances, the threshold concentration, and the tolerance of luminescent bacteria to different substances. The maximum promotion of bacterial luminescence intensity was 29% for Bisphenol A at 0.005 mg/L and the minimum threshold concentration of chromium was 0.004 mg/L, and the maximum bacterial tolerance to erythromycin is 6.74. In addition, most of the current environmental concentrations had a positive effect on luminescent bacteria and may still be in the range of concentrations that promote luminescence as the substances continue to accumulate. These findings will enhance the accuracy and comprehensiveness of toxicity assessments, thereby facilitating more informed and effective decision-making in the realms of environmental protection and pollution management.
Unveiling the Antiviral Potential of Minocycline: Modulation of Nuclear Export of Viral Ribonuclear Proteins during Influenza Virus Infection
Authors: Saha Priyanka , Saha Ritubrita , Datta Chaudhuri Ratul , Sarkar Rakesh , Sarkar Mehuli , Koley Hemanta , Chawla-Sarkar Mamta
Published: August 2024

Influenza A virus (IAV) poses a global threat worldwide causing pandemics, epidemics, and seasonal outbreaks. Annual modification of vaccines is costly due to continual shifts in circulating genotypes, leading to inadequate coverage in low- and middle-income countries like India. Additionally, IAVs are evolving resistance to approved antivirals, necessitating a search for alternative treatments. In this study, the antiviral role of the FDA-approved antibiotic minocycline against IAV strains was evaluated in vitro and in vivo by quantifying viral gene expression by qRT-PCR, viral protein levels by Western blotting, and viral titers. Our findings demonstrate that minocycline at a non-toxic dose effectively inhibits IAV replication, regardless of viral strain or cell line. Its antiviral mechanism operates independently of interferon signaling by targeting the MEK/ERK signaling pathway, which is crucial for the export of viral ribonucleoproteins (vRNPs). Minocycline prevents the assembly and release of infectious viral particles by causing the accumulation of vRNPs within the nucleus. Moreover, minocycline also inhibits IAV-induced late-stage apoptosis, further suppressing viral propagation. The antiviral activity of minocycline against IAVs could offer a promising solution amidst the challenges posed by influenza and the limitations of current treatments.
SARS-CoV-2 Vaccination Responses in Anti-CD20-Treated Progressive Multiple Sclerosis Patients Show Immunosenescence in Antigen-Specific B and T Cells
Authors: De Biasi Sara , Ciobanu Alin Liviu , Santacroce Elena , Lo Tartaro Domenico , Degliesposti Gianluca , D’Angerio Miriam , Leccese Maristella , Cardi Martina , Trenti Tommaso , Cuccorese Michela , Gibellini Lara , Ferraro Diana , Cossarizza Andrea
Published: August 2024

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) shows that inflammation starts early and progresses with age. B cells play a central role in this process, contributing to cytokine production, defective regulatory functions, and abnormal immunoglobulin production, even in the central nervous system. Anti-CD20 (aCD20) therapies, which deplete CD20+ B cells, are largely used in the treatment of both relapsing remitting (RR) and progressive (PR) forms of MS. Although effective against MS symptoms and lesions detectable by magnetic resonance imaging, aCD20 therapies can reduce the immune response to COVID-19 vaccination. By using high-parameter flow cytometry, we examined the antigen-specific (Ag+) immune response six months post-third COVID-19 mRNA vaccination in MS patients with RR and PR forms on aCD20 therapy. Despite lower Ag+ B cell responses and lower levels of anti-SARS-CoV2, both total and neutralizing antibodies, RR and PR patients developed strong Ag+ T cell responses. We observed similar percentages and numbers of Ag+ CD4+ T cells and a high proportion of Ag+ CD8+ T cells, with slight differences in T cell phenotype and functionality; this, however, suggested the presence of differences in immune responses driven by age and disease severity.
Anti-RBD Antibody Levels and IFN-γ-Specific T Cell Response Are Associated with a More Rapid Swab Reversion in Patients with Multiple Sclerosis after the Booster Dose of COVID-19 Vaccination
Authors: Aiello Alessandra , Ruggieri Serena , Navarra Assunta , Tortorella Carla , Vanini Valentina , Haggiag Shalom , Prosperini Luca , Cuzzi Gilda , Salmi Andrea , Quartuccio Maria Esmeralda , Altera Anna Maria Gerarda , Meschi Silvia , Matusali Giulia , Vita Serena , Galgani Simonetta , Maggi Fabrizio , Nicastri Emanuele , Gasperini Claudio , Goletti Delia
Published: August 2024

This study investigated the incidence and severity of SARS-CoV-2 breakthrough infections (BIs) and the time to swab reversion in patients with multiple sclerosis (PwMS) after the booster dose of COVID-19 mRNA vaccines. We enrolled 64 PwMS who had completed the three-dose mRNA vaccine schedule and had never experienced COVID-19 before. Among the 64 PwMS, 43.8% had BIs with a median time since the third vaccine dose of 155 days. BIs occurred more frequently in ocrelizumab-treated patients (64.7%). Patients with a relapsing-remitting MS course showed a reduced incidence of BIs compared with those with a primary-progressive disease (p = 0.002). Having anti-receptor-binding domain (RBD) antibodies represented a protective factor reducing the incidence of BIs by 60% (p = 0.042). The majority of BIs were mild, and the only severe COVID-19 cases were reported in patients with a high Expanded Disability Status Scale score (EDSS > 6). The median time for a negative swab was 11 days. Notably, fingolimod-treated patients take longer for a swab-negativization (p = 0.002). Conversely, having anti-RBD antibodies ≥ 809 BAU/mL and an IFN-γ-specific T cell response ≥ 16 pg/mL were associated with a shorter time to swab-negativization (p = 0.051 and p = 0.018, respectively). In conclusion, the immunological protection from SARS-CoV-2 infection may differ among PwMS according to DMTs.
Degradation of Bisphenol A Using Self-Excited Oscillating Jets in Synergy with Fenton and Periodate Oxidation: Experimental and Artificial Neural Network Modeling Study
Authors: Wang Jian , Li Bingsheng , Xie Shiwei , Ji Bin
Published: August 2024

Bisphenol A (BPA) is an environmental endocrine-disrupting compound that is resistant to conventional biological treatment, making it crucial to develop an oxidation process. This study introduces a novel hydrodynamic cavitation (HC) coupled with a Fenton + periodate (PI) oxidation system for the efficient degradation of BPA. By systematically examining the key parameters such as inlet pressure, Fe (II), H2O2, and PI concentration, it was found that HC performed optimally at a pressure of 0.5 MPa. A conversion of 98.14% was achieved within 60 min when the molar ratio of BPA, Fe (II), H2O2, and PI was approximately 1:1:5:1. Further analysis revealed that the gray correlation between H2O2 and PI concentrations on the degradation efficiency was 0.833 and 0.843, respectively, indicating that both of them had significant effects on the degradation process. The free radical quenching assay confirmed the hydroxyl radical (•OH) as the main active substance. Additionally, the toxicity of the degradation intermediates was evaluated using the Toxicity Estimation Software Tool (TEST). An artificial neural network (ANN)-based model was constructed to predict the BPA-degradation process, facilitating precise reagent dosing and providing robust support for the intelligent application of water-treatment technologies.
Tokadî-zâde Şekîb’in Neşîde-i Vicdân’ındaki Manzum Metinler
Authors: Demirbağ Abdulsamet
Published: August 2024

Tokadî-zâde Şekîb, XX. yüzyıl klasik Türk edebiyatı geleneğini devam ettiren şahsiyetlerden biridir. Birçok eser kaleme alan Şekîb’in bu eserlerinden biri de manzum ve mensur metinler içeren Neşîde-i Vicdân’dır. Neşîde-i Vicdân’ın manzum kısmında gazel, kaside, mesnevi, terkib-bend, kıta ve murabba nazım şekilleri ile yazılmış şiirler yer almaktadır. Şair, eserine bir kaside ile başlamış, bir kıta ile eserini sonlandırmıştır. Hz. Muhammed’e ve Ehl-i beyt’e dair derin bir muhabbetin gözlemlendiği şiirlerin bir kısmını dinî ve tasavvufi bağlamda değerlendirmek mümkündür. Özellikle naatlarda ve mersiyelerde bu hususun öne çıktığı, akıcı ve coşkun bir ruh hâlinin dikkat çektiği görülür. Aruz kusurlarına pek rastlanmayan şiirlerde Arapça ve özellikle Farsça terkipler yoğun olarak kullanılmıştır. Ayrıca manzumelerde mürdef kafiye fazlaca kullanılmıştır.
Bu çalışmada hacminden dolayı mensur metinler kapsam dışında tutulmuş, sadece manzum metinler üzerinde durulmuştur. Bu çerçevede önce şairin hayatı hakkında kısa bir bilgi verilmiş, sonra manzumelerin çeviri yazısı yapılarak manzumelerin yapı ve anlam özelliklerine yer verilmiştir. Çalışmanın sonuna ise eserin manzum bölümlerinin orijinal metni eklenmiştir.
Telomerase and mitochondria inhibition promote apoptosis and TET2 and ANMT3a expression in triple negative breast cancer cell lines
Authors: Mazloumi Zeinab , Rafat Ali , Dizaji Asl Khadijeh , Karimipour Mohammad , Shanehbandi Dariush , Talebi Mehdi , Montazer Majid , Movassaghpour Ali Akbar , Dehnad Alireza , Farahzadi Raheleh , Nozad Charoudeh Hojjatollah
Published: August 2024

Introduction: High metastasis, resistance to common treatments, and high mortality rate, has made triple-negative breast cancer (TNBC) to be the most invasive type of breast cancer. High telomerase activity and mitochondrial biogenesis are involved in breast cancer tumorigenesis. The catalytic subunit of telomerase, telomerase reverse transcriptase (hTERT), plays a role in telomere lengthening and extra-biological functions such as gene expression, mitochondria function, and apoptosis. In this study, it has been aimed to evaluate intrinsic-, extrinsic-apoptosis and DNMT3a and TET2 expression following the inhibition of telomerase and mitochondria respiration in TNBC cell lines. Methods: TNBC cells were treated with IC50 levels of BIBR1532, tigecycline, and also their combination. Then, telomere length, and DNMT3a, TET2, and hTERT expression were evaluated. Finally, apoptosis rate, apoptosis-related proteins, and genes were analyzed. Results: The present results showed that IC50 level of telomerase and inhibition of mitochondria respiration induced apoptosis but did not leave any significant effect on telomere length. The results also indicated that telomerase inhibition induced extrinsic-apoptosis in MDA-MB-231 and caused intrinsic- apoptosis in MDA-MB-468 cells. Furthermore, it was found that the expression of p53 decreased and was ineffective in cell apoptosis. The expressions of DNMT3a and TET2 increased in cells. In addition, combination treatment was better than BIBR1532 and tigecycline alone. Conclusion: The inhibition of telomerase and mitochondria respiration caused intrinsic- and extrinsic- apoptosis and increased DNMT3a and TET2 expression and it could be utilized in breast cancer treatment.
Material synthesis and design optimization of biomaterials for biomedical implant applications
Authors: Tipan Nilesh , Pandey Ajay , Mishra Pushyamitra
Published: August 2024

Introduction: In the modern era, the use of biomaterials in orthopaedics has revolutionised the healthcare sector. Traditionally, some non-biodegradable materials such as titanium and stainless steel are used as biomaterials. However, issues such as toxicity, poor tissue adhesion, and stress-shielding effect can occur with non-biodegradable materials for bone fracture fixation. Several biodegradable materials have been developed to resolve these issues but have not yet been appropriately industrialized for implant applications. These substances can be classified into metals, ceramics, and polymers, which can be blended to create composites that enhance biocompatibility and biomechanical characteristics. Methods: This study began by contrasting the biocompatibility and mechanical compatibility among various alloys: biodegradable low entropy (BLE) alloys, biodegradable medium entropy (BME) alloys, biodegradable high entropy (BHE) alloys, and non-biodegradable medium entropy (NBME) alloys. Additionally, the design morphology of bio-implants like plates, screws, and others was inspected. Moreover, a meta-analysis was conducted to optimize the design of biomaterials, ensuring appropriate biocompatibility and degradation rate. A subsequent statistical analysis was executed to determine the optimal material concentration for bio-implant alloy creation. Results: Initially, in this paper, the advantages of biodegradable materials over conventional non-biodegradable materials are discussed and bibliometric analysis is done to show recent research contributions in the field of biomedical implant application. Then compared biocompatibility and mechanical compatibility among BLE alloys, BME alloys, BHE alloys, NBME alloys. Furthermore, investigated the design morphology of bio-implants such as plates and screws. Also presented a meta-analysis for design optimization of biomaterials to meet suitable biocompatibility and biodegradation rates and presented a statistical analysis among them, which helps to select the appropriate material concentration for bio-implant alloy formation. Conclusion: It was observed that in biodegradable materials, tensile strength is in the pattern of NBME > BHE > BME > BLE, and the degradation rate is in the pattern of BME > NBME > BHE > BLE. This study suggests that biodegradable materials (BLE and BME) are a much better choice than non-biodegradable materials in orthopaedic applications. It was also observed that a Biodegradable locking compression plate (BLCP) can provide the necessary strength and performance. Further, the systematic meta-analysis presented herein furnishes crucial data to researchers, guiding them in enhancing the efficiency of diverse biomaterials and optimizing their designs.
Identification of key pathways and molecular players potentially involved in endometrial cancer metastasis through integrated bioinformatics analyses
Authors: Rezazadeh Maryam , Danaei-Mehrabad Shahla , Afshar Zakariya Nahideh , Kazemi Fatemeh , Moslehian Marziyeh Sadat , Tamadon Amin , Shirazi Reza , Mahdipour Mahdi , Hakimi Parvin
Published: August 2024

Introduction: Endometrial cancer (EC) is a particularly frequent gynecological cancer, and metastasis is the leading cause of death in patients with EC. Using publicly accessible gene expression data, a bioinformatics study was carried out to increase our knowledge and reveal treatment targets for EC metastasis. This study aimed to identify new important molecular actors and clarify the molecular processes and pathways underlying EC metastasis. Methods: The GEOexplorer and R programming languages were used to analyze and visualize gene expression data from EC metastatic gene expression datasets, and differentially expressed genes (DEGs) and differentially expressed lncRNAs (DElncRNAs) were identified using bioinformatics with P-value thresholds of < 0.05, and |log2FC| > 1.5. KEGG pathway enrichment analysis and gene ontology enrichment was used to enrich the observed DEGs, protein-protein interactions were established, and hub genes were identified. Results: The findings revealed that DEGs were considerably enriched in a number of pathways, including the "Pathways in cancer", "Breast cancer", and "Rap1 signaling pathway." DEGs were also found to be involved in a number of biological processes, cellular components, and molecular activities. The PPI network included the hub genes CTNNB1, FGFR3, ESR1, and SRSF3 as well as a number of DElncRNAs, such as LINC01541, SNHG17, LINC00520, BHLHE22-AS1, LOC100509445, H19, and HOTAIRM1. Conclusion: This study contributes to our understanding of the molecular processes driving EC metastasis, which may result in the development of new treatment targets and indicators for the early identification of EC metastasis. More studies are needed to validate these findings and to understand the functional roles of these key factors in EC metastasis.
Stimuli-responsive synthesis of silver nanoparticles applying green and chemical reduction approaches
Authors: Mohaghegh Seraj , Osouli-Bostanabad Karim , Nazemiyeh Hossein , Omidi Yadollah , Maleki-Ghaleh Hossein , Barzegar-Jalali Mohammad
Published: August 2024

Introduction: The current study reports the comparative stimuli-responsive synthesis of silver nanoparticles (AgNPs) with various sizes and morphologies employing Lycium ruthenicum extract and sodium citrate solutions. Methods: The morphology and size of AgNPs were regulated by varying the pH values, concentrations of the extract solution, and temperatures in the reaction medium. The prepared AgNPs were assessed via various instrumental analyses, including UV-Vis, FTIR, XRD, TEM, and DLS. Results: The L. ruthenicum extract displayed several functional groups that reduced the Ag ions to the AgNPs at different values of pH. However, the primary chemical structure of L. ruthenicum was virtually unaltered at these conditions. Variations in the pH and extract concentration of the reaction medium yielded AgNPs of different sizes and morphologies. Both bio- and chemo-synthesized AgNPs revealed a relatively dispersed sphere-shaped morphology under alkaline conditions (≈ 36 nm). Conclusion: This study introduced a simple, valuable, and green technique for stimuli-sensitive AgNPs synthesis employing the L. ruthenicum extract.
FEATURES OF THE ANOMALOUS MAGNETIC FIELD OFF THE NILMA-CHERNORECHENSKAYA WATER AREA AND THE GREAT SALMA STRAIT (Kandalaksha Bay)
Authors: Лыгин И.В. , Ивашкина О.О. , Кузнецов К.М. , Соколова Т.Б. , Токарев М.Ю. , Лыгина Е.А. , Морозов А.В.
Published: August 2024

В 2022 и 2023 годах вблизи Беломорской биологической станции имени Н.А. Перцова в акватории Кандалакшского залива проведены детальные магнитометрические работы. Магнитометрическая съемка 2023 года выполнена с использованием нового отечественного магнитометра-градиентометра MariMag 300m, обеспечившего определение аномалий магнитного поля со среднеквадратической погрешностью ±1 нТл. Геологический анализ аномального магнитного поля, поддержанный количественными расчетами модели объемного распределения намагниченности, позволил выявить новые линеаменты, природа которых может быть связана с повышенной намагниченностью пород вдоль разломов северо-западного простирания; в Нильма-Чернореченской акватории скорректировать границу формаций фундамента, выделить неизвестные ранее габброидные массивы и связать высокочастотные аномалии магнитного поля с аллювиальными отложениями в подводных руслах рек Черная и Нильма.

Detailed magnetic surveys were carried out near the White Sea Biological Station named by A.N. Pertsov in the waters of Kandalaksha Gulf in 2022 and 2023. The magnetic survey of 2023 was carried out by using a new Russian magnetometer-gradiometer «MariMag 300m» which provided the determination of magnetic field anomalies with a standard error of ±1 nT. The geological analysis of the anomalous magnetic field, supported by quantitative calculations of the 3D magnetization model, made it possible to identify new lineaments, the nature of which may be associated with increased magnetization of rocks along the faults of the northwestern stretch; to correct the boundary of the basement formations in the Nilma-Chernorechenskaya water area, to identify gabbroidal bodies which, were previously unknown, and to associate high-frequency magnetic field anomalies with alluvial deposits in the underwater riverbeds of the Chernaya and Nilma rivers.
CHANGE IN INHIBITION CONTROL IN CHILDREN 3-12 YEARS OLD
Authors: Теплова О.А.
Published: August 2024

Изучение исполнительных функций у детей дошкольного и младшего школьного возраста позволяет предсказать успешность обучения в школе. Именно поэтому целью данного исследования стал анализ возрастных особенностей функций тормозного контроля в управлении поведением. Рассмотрены средние значения показателей тормозного контроля у детей в возрасте от 3-х до 12 лет. В исследовании приняли участие 79 детей в возрасте от 3-х до 12 лет. Для оценки тормозного контроля использовалась компьютеризованная методика. Её смысл состоял в выработке у ребёнка определённой реакции, а потом в предъявлении требования её не выполнять. Число пропусков и ошибок у детей отражают сформированность у них тормозного контроля. В нашей работе мы брали и анализировали среднее число ошибок. Таким образом, мы можем сделать вывод, что сформированность тормозного контроля зависит от возраста. Все данные свидетельствуют о том, что окончательное формирование тормозного контроля выходит за пределы изучаемого возрастного диапазона.

The study of executive functions in children of preschool and primary school age makes it possible to predict the success of schooling. That is why the purpose of this study was to analyse the age-related features of the functions of inhibitory control in behaviour management. The average values of the indicators of inhibition control in children aged 3 to 12 years are considered. The study involved 79 children aged 3 to 12 years. A computerized technique was used to evaluate inhibition control. Its meaning was to develop a certain reaction in the child, and then to demand that it not be fulfilled. The number of omissions and errors in children reflect the formation of their inhibitory control. In our work, we took and analysed the average number of errors. Thus, we can conclude that the formation of inhibitory control depends on age. All the data indicate that the final formation of inhibitory control goes beyond the limits of the studied age range.
VALUE REFERENCES OF STUDENTS OF TECHNICAL COLLEGS OF ST. PETERSBURG
Authors: Резунков А.Г.
Published: August 2024

Целью работы является изучение жизненных ценностей современной российской молодежи в переломный момент времени на примере технических колледжей Санкт-Петербурга. Исследования были направлены на такие ориентиры, как такое добро, справедливость, любовь, дружба, патриотизм, политические предпочтения, жизненные проблемы и т. п. Исследования показали, что современная молодежь более прагматична, что есть перекосы, но они вполне исправимы при правильно организованном подходе.

The aim of the work is to study the life values of modern Russian youth at a turning point in time on the example of technical colleges in St. Petersburg. The studies were aimed at such guidelines as kindness, justice, love, friendship, patriotism, political preferences, life problems, etc. The studies have shown that modern youth is more pragmatic, that there are distortions, but they are quite correctable with a properly organized approach.
РSYCHOPHYSIOLOGICAL FUNCTIONS OF PRIMARY SCHOOL CHILDREN WITH HEARING IMPAIRMENT
Authors: Попова Т.В.
Published: August 2024

Изучалось возрастное развитие психофизиологических функций и возможность его коррекции у детей в возрасте 7-10 лет с нарушением слуховой афферентации (НС). У детей с НС выявлено отставание в возрастном развитии психофизиологических функций от здоровых сверстников. Коррекционные мероприятия, проведенные с учетом выявленных нами особенностей развития психофизиологических функций, показали как их эффективность, так и высокие адаптационные возможности у детей. Рекомендуется внедрять такие программы в процесс обучения детей младшего школьного возраста.

The age-related development of psychophysiological functions and the possibility of its correction in children aged 7-10 years with impaired auditory afferentation (NS) were studied. In children of NS, a lag in the age-related development of psychophysiological functions from healthy peers was revealed. Corrective measures carried out taking into account the features of the development of psychophysiological functions revealed by us showed both their effectiveness and high adaptive capabilities in children. It is recommended to introduce such programs in the process of teaching younger schoolchildren.
MENTAL AND CARDIOVASCULAR PATHOLOGY IN COVID-19: FEATURES OF INTERDRUG INTERACTIONS
Authors: Сергачев А.В. , Кирюхина С.В. , Кукина Г.Н. , Лабунский Д.А. , Подсеваткин В.Г.
Published: August 2024

Пандемия коронавирусной инфекции (COVID-19) внесла значительные изменения в жизнь всего мира и привела к многим социальным последствиям. Одними из них являются неблагоприятные эффекты со стороны коморбидного психического и соматического здоровья, которые принимают самые различные формы. Остаются нерешенными вопросы терапии коморбидной патологии сердечно-сосудистой системы в период Лонг-ковида, имеются сложности в исследовании нежелательных побочных реакций, возникающих от применяемых для лечения лекарственных препаратов. Токсические изменения со стороны внутренних органов нередко трудно отличить от самостоятельных соматических заболеваний. Ввиду этого необходимо исследовать патологические реакции, которые могут наблюдаться при взаимодействии препаратов, используемых для лечения COVID-19, сердечно-сосудистой патологии и антипсихотических лекарственных средств. В статье рассматриваются клинические проявления данных коморбидных заболеваний и обсуждаются перспективные возможности их лечения на примере клинического случая пациентки с сердечно-сосудистой и психической патологией, перенесшей коронавирусную инфекцию и находившуюся на терапии препаратом Ритонавир. Нами выявлено, что межлекарственные взаимодействия вызывают более высокие риски развития и усугубления сердечных нарушений, которые наиболее значимы в первые месяцы после перенесенной инфекции.

Coronavirus pandemic (COVID-19) has made significant changes in the life of the whole world and has led to many social consequences. Some of them are the adverse effects of comorbid mental and somatic health, which take a variety of forms. The issues of treatment of comorbid pathology of the cardiovascular system during the Long-covid period remains unresolved, there are difficulties in the study of undesirable side reactions arising from medications used for treatment. Toxic changes from the internal organs are often difficult to distinguish from independent somatic diseases. In view of this, it is necessary to investigate the pathological reactions that can be observed during the interaction of drugs used for the treatment of COVID-19, cardiovascular pathology and antipsychotic drugs. This article discusses the clinical manifestations of these comorbid diseases and the promising possibilities of their treatment in the clinical case example of a patient with cardiovascular and mental pathology who had a coronavirus infection and was on therapy with Ritonavir. We have found that drug interactions cause higher risks of development and aggravation of cardiac disorders, which are most significant in the first months after infection.
POSSIBILITIES OF DIGITAL TECHNOLOGIES IN SOCIO-PSYCHOLOGICAL ADAPTATION OF MILITARY SERVICEMEN RESERVED
Authors: Михеев А.В. , Тегза В.Ю.
Published: August 2024

Обеспечение оптимальной социально-психологической адаптации военнослужащих, уволенных в запас, является задачей государственной важности. Однако вопросы профессиональной переподготовки военнослужащих тесно переплетены не только с социальными и административными задачами, но и с педагогическими, психологическими, а также медицинскими, социальными и реабилитационными мероприятиями. Применимость компьютерных систем для адаптации обусловлена тем, что компьютерные программы обладают рядом объективных преимуществ, в первую очередь обработкой больших объемов данных и эффективностью.

Ensuring optimal socio-psychological adaptation of military personnel transferred to the reserve is a task of national importance. However, the issues of professional retraining of the military are closely intertwined not only with social and administrative tasks, but also with pedagogical, psychological, as well as medical, social and rehabilitation measures. The applicability of computer systems for adaptation is due to the fact that computer programs have a number of objective advantages, primarily processing large amounts of data and efficiency.
CRITICAL ANALYSIS OF THE SCIENTIFIC KNOWLEDGE OF THE NATURE OF MENTAL ACTIVITY OF THE BRAIN
Authors: Юматов Е.А.
Published: August 2024

В обзорной статье рассматривается проблема познания природы и теории психической деятельности мозга. Впервые показано, что субъективные состояния человека можно дистанционно объективно регистрировать. Установлено существование "психогенного поля", отражающего субъективное состояние головного мозга человека. Показано дистанционное влияние субъективного состояния человека на физико-химические показатели крови. Описано взаимодействие нейрофизиологических и психических процессов в системной организации целенаправленного поведения. Представлена принципиальная схема формирования психической деятельности мозга человека, основанная на обратном влиянии психогенного поля на нейронные молекулярные процессы (самоиндукция в мозге). Предложена "Психогенная теория сознания", рассматривающая происхождение субъективного состояния и возможность существования уникальных для живого мозга физических явлений и мозговых полей.

The review article examines the problem of understanding the nature of the mental activity of the brain. The goal of this study is to future explore the human subjective states which are can be registered remotely and objectively. Recently we have established the existence of a "psychogenic field", which are most likely reflecting on the human brain subjective state. The author analyses the remote influence of a human subjective state on the blood physical and chemical parameters. We have submitted the schematic diagram of formation of subjective human brain activity, based on biofeedback action of a psychogenic field to the neural molecular processes (a self-induction in a brain). The paper describes the interrelation of neurophysiologic and subjective processes in the system organization of goal-seeking behavior. A "Psychogenic theory of consciousness" is proposed, suggests presuming the existence of physical phenomena unique for the living brain and brain fields, and their role in the origin of a subjective state.
ON THE DURATION OF THE "CARRENT PRESENT"
Authors: Бушов Ю.В.
Published: August 2024

В последние годы в философской и психологической литературе, посвященной восприятию времени, активно обсуждается вопрос о содержании и длительности осознаваемого настоящего. В данной работе на основе концепции "информационного синтеза" А. М. Иваницкого предпринята попытка определить длительность "текущего настоящего". Анализ литературы показал, что на сегодняшний день отсутствует единая концепция настоящего и оценка его длительности. На основе концепции "информационного синтеза" А. М. Иваницкого предполагается, что длительность "текущего настоящего", которое включает "всё то, что мы осознаем и анализируем прямо сейчас", составляет 300-500 мс.

In recent years, in the philosophical and psychological literature devoted to the perception of time, the question of the content and duration of the conscious present has been actively discussed. In this paper, based on the concept of "information synthesis" by A.M. Ivanitsky, an attempt is made to determine the duration of the "current present". An analysis of the literature has shown that today there is no unified concept of the present and an assessment of its duration. Based on the concept of "information synthesis" by A.M. Ivanitsky, it is assumed that the duration of the "current present", which includes "everything that we are aware of and analyzing right now", is 300-500 ms.
ADAPTIVE CAPABILITIES OF PERSONALITY IN BORDERLINE DISORDER
Authors: Халфина Р.Р. , Хабибуллина И.Р. , Данилов Е.В.
Published: August 2024

В статье описреаны результаты исследования особенностей адаптационные возможности личности при пограничном расстройстве. Исторически термин "пограничный" был предметом многочисленных споров. Раньше ПРЛ считалась "границей" между психозом и неврозом. Название прижилось, хотя оно не очень хорошо описывает состояние и, на самом деле, может быть скорее вредным, чем полезным. Термин "пограничный" также имеет историю неправильного использования и предубеждений: ПРЛ - это клинический диагноз, а не суждение. Полученные в ходе нашего исследования результаты свидетельствуют о том, что по методике "Адаптивность" значимых различий между группами в таких факторах, как "психическая устойчивость", "коммуникативные способности" и "моральная нормативность" нет, соответственно нет различий между общей адаптацией в эмпирической и контрольной группе. Респондентам обеих выборок свойственна высокая нормативность поведения. Они добросовестны, ответственны, стабильны и уравновешены, что необходимо в деятельности.

The article describes the results of a study of the features of the adaptive capabilities of a person with borderline disorder. Historically, the term "borderline" has been the subject of numerous disputes. Previously, PRL was considered the "border" between psychosis and neurosis. The name stuck, although it does not describe the condition very well and, in fact, may be more harmful than useful. The term "borderline" also has a history of misuse and prejudice: PRL is a clinical diagnosis, not a judgment. The results obtained in the course of our study indicate that there are no significant differences between groups in such factors as "mental stability", "communicative abilities" and "moral normativity" according to the "Adaptability" method, respectively, there are no differences between the general adaptation in the empirical and control groups. Respondents of both samples are characterized by high normative behavior. They are conscientious, responsible, stable and balanced, which is necessary in their activities.
THE RELATIONSHIP OF THE FORMATION OF THE MENTAL MODEL WITH THE CHARACTERISTICS OF THE FAMILY AND LATERAL PREFERENCES OF A STUTTERING PRESCHOOLER
Authors: Брисберг Т.Л.
Published: August 2024

Поскольку заикание считается заболеванием, связанным с коммуникацией, то в работе была поставлена цель оценить взаимосвязь характеристик, имеющих отношение к коммуникации в семье у ребенка дошкольного возраста с заиканием. Было обследовано 38 детей 5-7 лет. Родители детей заполняли анкету, в которой были указаны особенности семьи, в которой развивался ребенок. Кроме этого, оценивался профиль функциональной сенсомоторной асимметрии ребенка с помощью набора тестов, наиболее часто применяющихся в практике психологов. Было показано, что модель психического ребенка, позволяющая ему понимать причины поведения других людей, тем лучше сформирована, чем старше возраст отца при рождении ребенка и больше правых признаков в профиле функциональной сенсомоторной асимметрии.

Since stuttering is considered a communication-related disease, the aim of the work was to evaluate the relationship of characteristics related to communication in the family of a preschool child with stuttering. 38 5-7-year-old children were examined. The parents of the children filled out a questionnaire in which the characteristics of the family in which the child was developing were indicated. In addition, the profile of functional sensorimotor asymmetry of the child was evaluated using a set of tests most often used in the practice of psychologists. It was shown that the model of a mental child that allows him to understand the causes of other people's behavior is the better formed, the older the age of the father at the birth of the child and the more right signs in the profile of functional sensorimotor asymmetry.
DEVELOPING A MODEL FOR ASSESSING HUMAN STATES DURING TRAINING SES
Authors: Демарева В.А.
Published: August 2024

Контроль состояния человека при тренировках является критически важным для обеспечения эффективности и безопасности при выполнении физических нагрузок. Исследование направлено на разработку модели для определения состояния человека в процессе спортивных тренировок. Были проведены лабораторные эксперименты с регистрацией ритма сердца в ходе часовой тренировки в тренажёрном зале при выполнении разных упражнений. Выборку исследования составили 20 человек (10 мужчин и 10 женщин) в возрасте 19-36 лет, без хронических заболеваний. При анализе результатов исследования было выявлено, что в ходе тренировок возможно наступление околокритических состояний, которые проявлялись в резком увеличении симпатовагусного баланса, снижении общей мощности спектра вариабельности ритма сердца, а также некоторым увеличением фрагментации ритма сердца. Баллы по анализу фигур сигнала (ритма сердца) также изменялись при наступлении околокритических состояний. На основании полученных результатов была сформулирована версия модели для определения состояния на основании анализа ритма сердца в ходе спортивных тренировок.

Monitoring an individual's condition during workouts is critically important for ensuring the effectiveness and safety of physical exertion. This research aims to develop a model for assessing a person's state during sports training sessions. Laboratory experiments were conducted, recording heart rhythms during a one-hour workout session in a gym involving various exercises. The study included a sample of 20 participants (10 men and 10 women) aged 19 to 36 years without chronic illnesses. Analysis of the research results revealed the possibility of reaching near-critical states during workouts, characterized by a sharp increase in the sympathovagal balance, a decrease in the overall power of heart rate variability spectra, and a certain increase in heart rate fragmentation. Scores from the signal pattern analysis (heart rate) also changed during these near-critical states. Based on these findings, a model version was formulated to determine an individual's state by analyzing heart rhythm during sports training sessions.
COGNITIVE IMPAIRMENTS IN OLDER PEOPLE
Authors: Шаяхметова Э.Ш. , Шурухина Г.А. , Макушкина О.М. , Султанова О.Р. , Темняткина Е.Н.
Published: August 2024

Цель исследования – выявление особенностей когнитивных нарушений у лиц старческого возраста. В исследовании приняли участие 40 лиц пожилого возраста 65,6±3,2 лет и 40 лиц старческого возраста 78,2±5,2 лет. Группы комплектовались в соответствии с возрастной градацией ВОЗ. Когнитивный статус пожилых людей оценивали с помощью Монреальского когнитивного теста, краткой шкалы оценки психического статуса, пробы Шульте–Горбова, методики «10 слов», методики «Вербальных ассоциаций». В результате исследования было определено, что у лиц старческого возраста выраженные нарушения памяти и интеллекта, истощаемость мнестической функции и снижен темп нервно-психических процессов и семантической памяти.

The purpose of the study is to identify the characteristics of cognitive impairment in elderly people. The study involved 40 elderly people aged 65,6±3,2 years and 40 elderly people aged 78,2±5,2 years. The groups were completed in accordance with the age gradation of the AllRussian Health Organization. The cognitive status of older people was assessed using the Montreal Cognitive Test, the Brief Mental Status Assessment Scale, the Schulte-Gorbov test, the «10 Words»

technique, and the «Verbal Associations» technique. As a result of the study, it was determined that elderly people have severe impairments of memory and intelligence, exhaustion of mnestic function and a reduced rate of neuropsychic processes and semantic memory.
ON THE MEANING OF HUMAN LIFE (NEOCLASSICAL DISCOURSE)
Authors: Меньчиков Г.П.
Published: August 2024

В данной статье предпринимается попытка проанализировать сущность смысла жизни человека, его фундирующие основания и причины его огромного значения, особенно в период постсекулярной эпохи.

This article attempts to analyze the essence of the meaning of human life, its fundamental bases and reasons for its great importance, especially in the post-secular era.
CREATIVITY AND COMMUNICATIVE QUALITIES OF STUDENTS
Authors: Ермакова Е.С.
Published: August 2024

Исследование выявило различия в структуре связей показателей социальной, личностной креативности, аффилиации и коммуникативных ориентаций студентов разных направлений подготовки. Отмечено сходство факторной структуры личностных качеств студентов, обеспечивающих творческий потенциал и связанных с мотивационными особенностями межличностного взаимодействия.

The study revealed differences in the structure of the links of indicators of social, personal creativity, affiliation and communicative orientations of students of different training areas. The similarity of the factor structure of students' personal qualities providing creative potential and related to the motivational features of interpersonal interaction is noted.
FEATURES OF THE INFLUENCE OF COMPLEX THERAPY ON THE DYNAMICS OF HOMEOSTASIS INDICATORS IN PERSONS WHO HAVE SUFFERED STROKE
Authors: Кузьмина B.A. , Кирюхина С.В.
Published: August 2024

Ишемический инсульт - состояние, которое по-прежнему актуально в современной медицине. Процент больных, без наличия каких-либо осложнений составляет от 13 до 16 %. [1]. Причиной психических осложнений при ишемическом инсульте с точки зрения психофизиологии можно считать гипоксию. Данные предыдущих исследований также свидетельствуют об этом. Например, недостаток кислорода способен спровоцировать развитие депрессии, шизофрении, шизотипического и бредового расстройства, в дополнение этого гипоксия вызывает уменьшение коры головного мозга [2]. Кроме того, ишемический инсульт наблюдается у лиц у лиц молодого возраста (55 лет и младше) все чаще [3].

Ischemic stroke is a disease with numerous complications increasingly affecting individuals of working age. One notable complication is mental illness, significantly diminishing quality of life and often leading to disability. This study aims to identify correlations between laboratory parameters and mental disorders, crucial for developing prevention programs. Specifically, it investigates the relationship between laboratory blood parameters and the occurrence of excitable personality traits, phobic tendencies, and subdepressive syndromes in ischemic stroke patients, evaluating differences between patients with and without diabetes mellitus or other metabolic diseases. Materials and Methods. Laboratory parameters were compared between ischemic stroke patients (ICD-10 code I63.5) with and without mental disorders (n=20). The incidence of mental changes across different age groups was also assessed.
DEPRESSIVE STATES AFTER A CORONAVIRUS INFECTION
Authors: Кирюхина С.В. , Подсеваткин В.Г. , Подъячева Е.Н. , Корнев Н.С.
Published: August 2024

Актуальность проблемы новой коронавирусной инфекции до сих пор продолжает представлять серьёзную угрозу для глобального общественного здравоохранения. Хотя COVID-19 в первую очередь поражает дыхательную систему, вызывая тяжелую пневмонию и острый респираторный дистресс-синдром в тяжелых случаях, он также может приводить к множественным осложнениям, в том числе и депрессивные состояния. В статье представлен анализ структуры и динамики распространённости депрессивных состояний после перенесённой коронавирусной инфекции, а также их профилактика. Диагностика проводилась с помощью клинических методов и психодиагностических тестов (опросник Бека, шкала Спилбергера-Ханина).

The urgency of the problem of the new coronavirus infection still continues to pose a serious threat to global public health. Although COVID-19 primarily affects the respiratory system, causing severe pneumonia and acute respiratory distress syndrome in severe cases, it can also lead to multiple complications, including depressive states. The article presents an analysis of the structure and dynamics of the prevalence of depressive states after coronavirus infection, as well as prevention. The diagnosis was carried out using clinical methods and psychodiagnostic tests (Beck's questionnaire, Spielberger-Hanin scale).
FEATURES OF THE USE OF NON-STEROID ANTI-INFLAMMATORY DRUGS IN DENTAL INTERVENTIONS
Authors: Качалов А.Б. , Резункова О.П. , Тегза В.Ю.
Published: August 2024

Современную стоматологию невозможно представить без анестезии и противовоспалительного лечения, но даже самые современные препараты, позиционированные как «обладающие минимальными побочными эффектами» и «достаточно безопасные» на самом деле обладают достаточно выраженной кардиотоксичностью. Основными критериями, которым должны соответствовать применяемые пациентами нестероидных противовоспалительных препаратов, являются: адекватность клинической ситуации, безопасность, эффективность. Однако, если выбор лечебного средства выполнен без учета сопутствующей соматической патологии, появляется опасность нанесения вреда здоровью пациенту как по рекомендации лечащего врача, так и при самостоятельном применении препарата пациентом. К

Modern dentistry cannot be imagined without anesthesia and anti-inflammatory treatment, but even the most modern drugs, positioned as “having minimal side effects” and “reasonably safe,” actually have quite pronounced cardiotoxicity. The main criteria that non-steroidal antiinflammatory drugs used by patients must meet are: adequacy of the clinical situation, safety, effectiveness. However, if the choice of a therapeutic agent is made without taking into account concomitant somatic pathology, there is a danger of causing harm to the patient’s health, both on the recommendation of the attending physician and when the patient self-administers the drug