bluuebunny/crossref_metadata_2025 huggingface dataset:
Governance Capability of the Public Health System: A Comparative Analysis of the Control of COVID-19 in the Different Provinces of China
Authors: Fang Yingfeng , Zhang Fen , Zhou Chenyu , Chen Ming
Published: April 2021

At the beginning of 2020, the global outbreak of the novel coronavirus COVID-19 posed a huge challenge to the governance capabilities of public health in various countries. In this paper, the SEIR model is used to fit the number of confirmed cases in each province in China, and the reduction rate of the basic reproduction number is used to measure the actual score of the control effect of COVID-19. The potential capacity of prevention and control of epidemics, in theory, is constructed, and we use the difference between theoretical ability and actual score to measure the ability of governance of public health. We found that there were significant differences between actual effect and theoretical ability in various regions, and governance capabilities were an important reason leading to this difference, which was not consistent with the level of economic development. The balance of multiple objectives, the guiding ideology of emphasizing medical treatment over prevention, the fragmentation of the public health system, and the insufficiency of prevention and control ability in primary public health systems seriously affected the government’s ability to respond to public health emergencies.
Bio-Mercury Remediation Suitability Index: A Novel Proposal That Compiles the PGPR Features of Bacterial Strains and Its Potential Use in Phytoremediation
Authors: Robas Marina , Jiménez Pedro A. , González Daniel , Probanza Agustín
Published: April 2021

Soil pollution from heavy metals, especially mercury, is an environmental problem for human health. Biological approaches offer interesting tools, which necessarily involve the selection of organisms capable of transforming the environment via bioremediation. To evaluate the potential use of microorganisms in phytorhizoremediation, bacterial strains were isolated from rhizospheric and bulk soil under conditions of chronic natural mercury, which were identified and characterized by studying the following: (i) their plant growth promoting rhizobacteria (PGPR) activities; and (ii) their maximum bactericide concentration of mercury. Information regarding auxin production, phosphate solubilization, siderophore synthesis and 1-aminocyclopropane-1-carboxylic acid deaminase (ACCd) capacity of the isolates was compiled in order to select the strains that fit potential biotechnological use. To achieve this objective, the present work proposes the Bio-Mercury Remediation Suitability Index (BMR-SI), which reflects the integral behavior of the strains for heavy metal polluted soil bioremediation. Only those strains that rigorously fulfilled all of the established criteria were selected for further assays.
Massive Edema of the Lower Limbs in Patients after Spinal Cord Injury—One Picture, Different Diagnoses
Authors: Mackiewicz-Milewska Magdalena , Cisowska-Adamiak Małgorzata , Sakwińska Katarzyna , Szymkuć-Bukowska Iwona , Głowacka-Mrotek Iwona
Published: April 2021

Diagnosis of the cause of massive edema of the lower limbs in patients after spinal cord injury (SCI) can be difficult because of loss of pain sensation, commonly occurring in this group of patients. This paper reviews several different pathologies that can lead to lower-limb edema and the associated diagnostic difficulties. We present four cases of patients with massive edemas of lower limbs at different times after SCI undergoing treatment in the Department of Rehabilitation, University Hospital in Bydgoszcz, Poland. All patients had a lack of pain sensation in the lower limbs and significantly elevated levels of D-dimer. In two cases, deep vein thrombosis (DVT) and intramuscular hematomas (IHs) were diagnosed. IHs were probably a consequence of antithrombotic treatments implemented due to the occurrence of DVT. Heterotopic ossification (HO) was diagnosed in a third case, and, in another patient, who was hospitalized for the longest period after injury, we found humeral bone fractures. Heterotopic ossification, intramuscular haematomas, and bone fractures of the lower limb can mimic DVT. Careful observation of the edema evolution is recommended, as the onset of new symptoms may indicate a different cause of edema from that initially established.
Assessment of the Health Behaviours and Value-Based Health Analysis of People Aged 50+ Who Were Hospitalized Due to Cardiovascular Disease
Authors: Gąska Izabela , Sygit Katarzyna , Cipora Elżbieta , Sygit Marian , Pacian Anna , Surmach Maryna , Kaleta Dorota , Rzeźnicki Adam
Published: April 2021

Introduction: The basic determinant of healthy behaviour—among other human behaviours—is the fact that it consistently affects health. Nowadays, health behaviour studies are considered to be an important method of measuring the health of a population. Objective: To assess the health behaviours and value-based health analysis of people aged 50+ who were hospitalized due to cardiovascular disease, depending on the selected descriptive variables. Materials and methods: The study was conducted between April 2018 and December 2018 among 411 subjects aged 50+ who were hospitalized due to cardiovascular disease at the Independent Public Health Care Unit in Sanok (Podkarpackie voivodship in Poland). The method used in the study was a diagnostic survey. The study used the authors’ survey questionnaire and two standardized tests: Inventory of Health-Related Behaviour (IHB) and List of Health Criteria (LHC). A statistical analysis was carried out in the R program, version 3.5.1. The obtained results were subjected to thorough statistical analysis using the following tests: Student’s t, Mann–Whitney U, ANOVA, Kruskal–Wallis, Fisher’s Least Significant Difference (LSD), Pearson, and Spearman. Results: The strongest correlation between health status and health behaviours (according to the IHB questionnaire) was in the area of ‘health practices’, while the lowest correlation was found in the areas of ‘correct eating habits’ and ‘preventive behaviours’. Based on the LHC questionnaire, the most important health criteria according to the subjects were ‘not feeling any physical ailments’; ‘having all body parts functional’; ‘feeling well’; ‘eating properly’; and ‘infrequent need of going to the doctor’. A positive correlation was found in the group of respondents where the ‘preventive health behaviours’ were more intense; herein, the more important criterion for the respondents was ‘eating properly’. Conclusions: Respondents aged 50+ and hospitalized for cardiovascular diseases indicated (based on the IHB questionnaire) that health behaviours in the area of ‘health practices’ had the strongest correlation with their health, while the lowest correlation was found in the areas of ‘correct eating habits’ and ‘preventive behaviours’. According to the respondents, the most important criteria determining health (according to the LHC questionnaire) included ’not feeling any physical ailments’; ‘having all body parts functional’; ‘feeling well’; ‘eating properly’; and ‘infrequent need of going to the doctor’. Based on the information collected from the respondents, it was found that the most important criteria determining health depended on selected descriptive variables, such as age, gender, place of residence, education, and marital status.
Exploring the Relationships between Safety Compliance, Safety Participation and Safety Outcomes: Considering the Moderating Role of Job Burnout
Authors: Yang Xiaoyi , Zhang Boling , Wang Lulu , Cao Lanxin , Tong Ruipeng
Published: April 2021

Safety compliance (SC) and safety participation (SP), which are key factors predicting safety outcomes (e.g., accidents, injuries and near misses), are related but distinct. However, which component is more significant remains controversial. Job burnout is a typical occupational psychological syndrome of employees that impacts safety outcomes, but the role that it plays in the relationship between SC, SP and safety outcomes is ambiguous. To clarify these relationships, Chinese coal mine workers were sampled. Then, hypotheses on the influencing mechanisms were initially proposed and later tested empirically. To conduct this testing, SC and SP scales were revised, and a job burnout scale was developed. The results showed that there were significant relationships between workers’ SC and SP and safety outcomes; meanwhile, exhaustion, cynicism and low professional efficacy had significant effects on these relationships. Job burnout acted as a significant and indispensable moderator. Moreover, workers’ occupational psychological health condition should be considered when improving safety outcomes.
Acute Effects of Work Rest Interval Duration of 3 HIIT Protocols on Cycling Power in Trained Young Adults
Authors: García-De Frutos José Manuel , Orquín-Castrillón Fco. Javier , Marcos-Pardo Pablo Jorge , Rubio-Arias Jacobo Á. , Martínez-Rodríguez Alejandro
Published: April 2021

High-Intensity Interval Training (HIIT) is described as a succession of short duration and maximum or near-maximum intensity efforts, alternated by recovery periods during which exercise continues at a lower intensity (active recovery) or is interrupted (passive recovery). Our objective was to evaluate the acute responses of three HIIT protocols of different work/rest interval times over the total time of the session, with self-selectable load and up to exhaustion, “all out”.The sample was composed of 22 male participants (n = 22) between 19 and 24 years old. The HIIT protocol consisted of one of the three HIIT protocols, of 30, 60 and 90 s density ratio 1:1 and with passive rest, with a total exercise duration of 10 min. The test was performed in a cycloergometer set in workload mode independent of the pedaling frequency. The comparison of the three HIIT protocols shows that the duration of the work/rest intervals, starting from 30 s of work, in the cycloergometer, there are no significant differences in the levels of lactate concentration in the blood, nor in the heart rate, since a similar amount is obtained in the three protocols. The percentage of maximum power developed reached in each HIIT protocol is related to the duration of the working intervals.
The Impact of Adolescent Internet Addiction on Sexual Online Victimization: The Mediating Effects of Sexting and Body Self-Esteem
Authors: Tamarit Alicia , Schoeps Konstanze , Peris-Hernández Montserrat , Montoya-Castilla Inmaculada
Published: April 2021

Adolescents’ problematic use of the internet and the risk of sexual online victimization are an increasing concern among families, researchers, professionals and society. This study aimed to analyze the interplay between adolescents’ addiction to social networks and internet, body self-esteem and sexual–erotic risk behavior online: sexting, sextortion and grooming. While sexting refers to the voluntary engagement in texting sexual–erotic messages, sextortion and grooming are means of sexual–erotic victimization through the use of the internet. Participants were 1763 adolescents (51% girls), aged 12 to 16 years (M = 14.56; SD = 1.16), from public (n = 1068; 60.60%) and private (n = 695; 39.40%) high schools in the Basque Country (Spain). We carried out structural equation modeling (SEM) using Mplus to assess the mediating effects of body self-esteem in the relationship between addiction to social media and internet and sexual–erotic risk behavior. The results showed that internet addiction predicts online sexual victimization; specifically, the best predictors of sexting, sextortion and grooming victimization were symptoms of internet addiction and geek behavior. Body self-esteem and sexting mediated the relationship between internet addiction and sexual online victimization in adolescents. These results highlight the importance of attending to adolescents’ mental health regarding their online behavior, considering the risk and protective factors involved, due to its close association with online sexual victimization.
Association between Sexual Behavior and Depression in South Korean Adolescents: A Cross-Sectional Study
Authors: Kim Hyunkyu , Jeong Wonjeong , Jang Sungin , Kim Youseok , Park Euncheol
Published: April 2021

Adolescent depression and suicide have become leading public health and socioeconomic problems. Determining the connection between adolescent behavior and depression can inform strategies to reduce the prevalence of depression and suicide. We investigated the association between sexual behavior and depression in South Korean adolescents. Data for this cross-sectional study were obtained from the 2017–2019 Korea Youth Risk Behavior Web-Based Survey. Data of 178,664 subjects were analyzed using chi-square tests and multivariate logistic regression. After adjusting for covariates, the prevalence of depression was found to be higher in subjects with experience of sexual intercourse (adjusted odds ratio = 1.71, 95% confidence interval = 1.59–1.83 in boys; adjusted odds ratio = 1.47, confidence interval = 1.33–1.61 in girls). On categorizing subjects into two groups based on suicidality, subjects with sexual intercourse experience had higher odds ratios for depression with suicidality (aOR:2.16 in boys, aOR:1.80in girls) than depression without suicidality (aOR:1.49 in boys, aOR:1.25 in girls). We identified the relationship between sexual behavior and the prevalence of depression; adolescents with experience of sexual intercourse were more likely to have depression with suicidality. Further research using prospective designs should serve as the basis for appropriate sex education policies to manage the relationship between sexual behavior and depression.
Noise Pollution and Its Correlations with Occupational Noise-Induced Hearing Loss in Cement Plants in Vietnam
Authors: Thai Tinh , Kučera Petr , Bernatik Ales
Published: April 2021

Noise-Induced Hearing Loss (NIHL) is a global issue that is caused by many factors. The purpose of this study was to survey noise level to identify NIHL and its relationship with other factors in cement plants in Vietnam. Noise level was measured at one cement plant and three cement grinding stations located in the South of Vietnam. The audiometric data of exposed workers were surveyed to determine NIHL. Finally, the relationship between NIHL and noise level in cement plants was determined. The results show that noise level in almost all processes exceeded the permissible exposure limit (PEL). In this study, 42 cases (10% of exposed workers) with occupational NIHL were found with mean age (SD) of 49 (9.0) years. All NIHL cases were found in the departments in which the noise level exceeded the PEL, which included quarry (n = 16), maintenance (n = 12), production (n = 10), co-waste processing (n = 3) and quality assurance (n = 1). There was a positive and significant correlation between the NIHL and the excessive noise exposure in the cement plants (r = 0.89, p = 0.04).
“Blood for Blood”? Personal Motives and Deterrents for Blood Donation in the German Population
Authors: Greffin Klara , Schmidt Silke , Schönborn Linda , Muehlan Holger
Published: April 2021

It is crucial to provide updated knowledge about blood (non-)donors, as it is necessary to design targeted interventions with the aim of retaining blood donors and thus contributing to a functioning health system. This study investigates the prevalence and socio-demographic patterning of lifetime blood donation, assessing blood donation intention within the next 12 months and exploring personal motives and deterrents of blood donation qualitatively in the German population. A face-to-face cross-sectional survey with 2531 respondents was conducted, representative of the German population in terms of age, gender, and residency. Closed as well as open questions were asked. Qualitative content analysis was used for coding the qualitative material. Basic descriptive statistics were conducted to address our research questions. More than one-third of the participants reported that they have donated blood at least once in their lifetime. Motives and deterrents were assigned to 10 domains with 50 main categories and 65 sub-categories. The most frequently stated motives for blood donation were “altruism”, “social responsibility”, and “charity”, whereas the most frequently stated deterrents were “health status”, “age”, and “lack of time”. This study provides information to tailor recruitment and reactivation strategies to address donors at different career steps—from non-donor to loyal donor.
Vaccination Prioritization Strategies for COVID-19 in Korea: A Mathematical Modeling Approach
Authors: Choi Yongin , Kim James Slghee , Kim Jung Eun , Choi Heejin , Lee Chang Hyeong
Published: April 2021

Coronavirus disease 2019 (COVID-19) vaccination has recently started worldwide. As the vaccine supply will be limited for a considerable period of time in many countries, it is important to devise the effective vaccination strategies that reduce the number of deaths and incidence of infection. One of the characteristics of COVID-19 is that the symptom, severity, and mortality of the disease differ by age. Thus, when the vaccination supply is limited, age-dependent vaccination priority strategy should be implemented to minimize the incidences and mortalities. In this study, we developed an age-structured model for describing the transmission dynamics of COVID-19, including vaccination. Using the model and actual epidemiological data in Korea, we estimated the infection probability for each age group under different levels of social distancing implemented in Korea and investigated the effective age-dependent vaccination strategies to reduce the confirmed cases and fatalities of COVID-19. We found that, in a lower level of social distancing, vaccination priority for the age groups with the highest transmission rates will reduce the incidence mostly, but, in higher levels of social distancing, prioritizing vaccination for the elderly age group reduces the infection incidences more effectively. To reduce mortalities, vaccination priority for the elderly age group is the best strategy in all scenarios of levels of social distancing. Furthermore, we investigated the effect of vaccine supply and efficacy on the reduction in incidence and mortality.
Narcissism and Exercise Addiction: The Mediating Roles of Exercise-Related Motives
Authors: Zeigler-Hill Virgil , Besser Avi , Gabay Maor , Young Gracynn
Published: April 2021

The present research examined whether the associations that narcissistic personality features had with exercise addiction were mediated by particular motives for engaging in exercise in a large Israeli community sample (N = 2629). The results revealed that each aspect of narcissism was positively associated with exercise addiction. Narcissistic admiration and narcissistic rivalry had similar positive indirect associations with exercise addiction through the interpersonal motive for exercise. However, these aspects of narcissism diverged in their indirect associations with exercise addiction through psychological motives, body-related motives, and fitness motives for exercise such that these indirect associations were positive for narcissistic admiration but negative for narcissistic rivalry. Narcissistic vulnerability had positive indirect associations with exercise addiction through body-related motives and fitness motives that were similar to those observed for narcissistic admiration. These results suggest that exercise-related motives may play important roles in the associations that narcissistic personality features have with exercise addiction. The discussion will focus on the implications of these results for understanding the complex connections between narcissism and exercise addiction.
Childbirth Care among SARS-CoV-2 Positive Women in Italy
Authors: Donati Serena , Corsi Edoardo , Salvatore Michele Antonio , Maraschini Alice , Bonassisa Silvia , Casucci Paola , Cataneo Ilaria , Cetin Irene , D’Aloja Paola , Dardanoni Gabriella , De Ambrosi Elena , Ferrazzi Enrico , Fieni Stefania , Franchi Massimo Piergiuseppe , Gargantini Gianluigi , Iurlaro Enrico , Leo Livio , Liberati Marco , Livio Stefania , Locci Mariavittoria , Marozio Luca , Martini Claudio , Maso Gianpaolo , Mecacci Federico , Meloni Alessandra , Mignuoli Anna Domenica , Patanè Luisa , Pellegrini Edda , Perotti Francesca , Perrone Enrica , Prefumo Federico , Ramenghi Luca , Rusciani Raffaella , Savasi Valeria , Schettini Sergio Crescenzo Antonio , Simeone Daniela , Simeone Serena , Spinillo Arsenio , Steinkasserer Martin , Tateo Saverio , Ternelli Giliana , Tironi Roberta , Trojano Vito , Vergani Patrizia , Zullino Sara
Published: April 2021

The new coronavirus emergency spread to Italy when little was known about the infection’s impact on mothers and newborns. This study aims to describe the extent to which clinical practice has protected childbirth physiology and preserved the mother–child bond during the first wave of the pandemic in Italy. A national population-based prospective cohort study was performed enrolling women with confirmed SARS-CoV-2 infection admitted for childbirth to any Italian hospital from 25 February to 31 July 2020. All cases were prospectively notified, and information on peripartum care (mother–newborn separation, skin-to-skin contact, breastfeeding, and rooming-in) and maternal and perinatal outcomes were collected in a structured form and entered in a web-based secure system. The paper describes a cohort of 525 SARS-CoV-2 positive women who gave birth. At hospital admission, 44.8% of the cohort was asymptomatic. At delivery, 51.9% of the mothers had a birth support person in the delivery room; the average caesarean section rate of 33.7% remained stable compared to the national figure. On average, 39.0% of mothers were separated from their newborns at birth, 26.6% practised skin-to-skin, 72.1% roomed in with their babies, and 79.6% of the infants received their mother’s milk. The infants separated and not separated from their SARS-CoV-2 positive mothers both had good outcomes. At the beginning of the pandemic, childbirth raised awareness and concern due to limited available evidence and led to “better safe than sorry” care choices. An improvement of the peripartum care indicators was observed over time.
The Impact of Individual Behaviors and Governmental Guidance Measures on Pandemic-Triggered Public Sentiment Based on System Dynamics and Cross-Validation
Authors: Huang Hainan , Chen Weifan , Xie Tian , Wei Yaoyao , Feng Ziqing , Wu Weijiong
Published: April 2021

Negative online public sentiment generated by government mishandling of pandemics and other disasters can easily trigger widespread panic and distrust, causing great harm. It is important to understand the law of public sentiment dissemination and use it in a timely and appropriate way. Using the big data of online public sentiment during the COVID-19 period, this paper analyzes and establishes a cross-validation based public sentiment system dynamics model which can simulate the evolution processes of public sentiment under the effects of individual behaviors and governmental guidance measures. A concrete case of a violation of relevant regulations during COVID-19 epidemic that sparked public sentiment in China is introduced as a study sample to test the effectiveness of the proposed method. By running the model, the results show that an increase in government responsiveness contributes to the spread of positive social sentiment but also promotes negative sentiment. Positive individual behavior suppresses negative emotions while promoting the spread of positive emotions. Changes in the disaster context (epidemic) have an impact on the spread of sentiment, but the effect is mediocre.
Purification of Wastewater from Biomass-Derived Syngas Scrubber Using Biochar and Activated Carbons
Authors: Catizzone Enrico , Sposato Corradino , Romanelli Assunta , Barisano Donatella , Cornacchia Giacinto , Marsico Luigi , Cozza Daniela , Migliori Massimo
Published: April 2021

Phenol is a major component in the scrubber wastewater used for syngas purification in biomass-based gasification plants. Adsorption is a common strategy for wastewater purification, and carbon materials, such as activated carbons and biochar, may be used for its remediation. In this work, we compare the adsorption behavior towards phenol of two biochar samples, produced by pyrolysis and gasification of lignocellulose biomass, with two commercial activated carbons. Obtained data were also used to assess the effect of textural properties (i.e., surface area) on phenol removal. Continuous tests in lab-scale columns were also carried out and the obtained data were processed with literature models in order to obtain design parameters for scale-up. Results clearly indicate the superiority of activated carbons due to the higher pore volume, although biomass-derived char may be more suitable from an economic and environmental point of view. The phenol adsorption capacity increases from about 65 m/g for gasification biochar to about 270 mg/g for the commercial activated carbon. Correspondingly, service time of commercial activated carbons was found to be about six times higher than that of gasification biochar. Finally, results indicate that phenol may be used as a model for characterizing the adsorption capacity of the investigated carbon materials, but in the case of real waste water the carbon usage rate should be considered at least 1.5 times higher than that calculated for phenol.
Discriminant Analysis of Anthropometric and Training Variables among Runners of Different Competitive Levels
Authors: Thuany Mabliny , Souza Raphael F. de , Hill Lee , Mesquita João Lino , Rosemann Thomas , Knechtle Beat , Pereira Sara , Gomes Thayse Natacha
Published: April 2021

The purpose of this study was to investigate the multivariate profile of different types of Brazilian runners and to identify the discriminant pattern of the distinct types of runners, as a runners’ ability to self-classify well. The sample comprised 1235 Brazilian runners of both sexes (492 women; 743 men), with a mean age of 37.94 ± 9.46 years. Individual characteristics were obtained through an online questionnaire: Sex, age, body height (m) and body mass (kg), socioeconomic status, and training information (i.e., self-classification, practice time, practice motivation, running pace, frequency and training volume/week). Multivariate analysis of variance was conducted by sex and the discriminant analysis was used to identify which among running pace, practice time, body mass index and volume/training could differentiate groups such as “professional athletes”, “amateur athletes” and “recreational athletes”. For both sexes, running pace was the variable that better discriminated the groups, followed by BMI and volume/week. The practice time is not a good indicator to differentiate runner’s types. In both sexes, semi-professional runners were those that better self-classify themselves, with amateur runners presenting the highest classification error. This information can be used to guide the long-term training, athlete’s selection programs, and to identify the strengths and weaknesses of athletes.
Safety.Net: A Pilot Study on a Multi-Risk Internet Prevention Program
Authors: Ortega-Barón Jéssica , González-Cabrera Joaquín , Machimbarrena Juan M. , Montiel Irene
Published: April 2021

Many programs exist to prevent bullying and cyberbullying. Nevertheless, despite evidence of the numerous overlapping risks of the Internet, programs that jointly and adequately address large sets of risks are not presently described in the scientific literature. This study’s main objective was to assess the effectiveness of the Safety.net program in a pilot sample. This program prevents eight Internet risks: cyberbullying, sexting, online grooming, cyber dating abuse, problematic Internet use, nomophobia, Internet gaming disorder, and online gambling disorder. The Safety.net program comprises 16 sessions and 4 modules (digital skills, relational risks, dysfunctional risks, and change of attitudes and cognitions). Each session lasts one hour, but the program has a networked instructional design to recall previous content in later sessions. For its assessment, a pre/post-test repeated measures design with a control group and an intervention group was used. The study sample was 165 adolescents between 11 and 14 years old (M = 12.11, SD = 0.89). The intervention group demonstrated improvements compared to the control group concerning online grooming, problematic Internet use, Internet gaming disorder, and nomophobia. These results suggest that the Safety.net program is effective in preventing the increase of most of the assessed risks and that it reduces some of them with a small number of sessions.
Short-Selling and Financial Performance of SMEs in China: The Mediating Role of CSR Performance
Authors: Mai Wenzhen , Hamid Nik Intan Norhan binti Abdul
Published: April 2021

The aim of this study is to examine the effect of short-selling deregulation on the financial performance of SMEs in China. The external governance role of short-selling is also tested by adopting corporate social responsibility (CSR) performance as the mediating effect. This study investigates a panel data analysis with a sample of 5038 firm-years of SMEs listed in Shenzhen Stock Exchange from 2010 to 2019. The PSM-DID method is adopted in this study to alleviate self-selection and endogenous problems to observe the comparable pure effect of short-selling deregulation, while the mediation test is conducted based on Baron and Kenny’s model. The finding of this study showed that the existence of short-selling could enhance firm financial performance and the mediating effect of CSR performance position in their relationship. In addition, the further analysis revealed that the mediating effect of CSR is more pronounced for family businesses and firms with high real short-selling threats. The robust test of alternative measurements is conducted and valid. This study provides insights for policymakers to consider further short-selling ban lifting and corporate executives to practice more CSR activities to improve the financial performance. Limitations and further implications of this study are also discussed.
The Mechanisms of the Development of Atherosclerosis in Prediabetes
Authors: Liang Yin , Wang Mengxue , Wang Chen , Liu Yun , Naruse Keiji , Takahashi Ken
Published: April 2021

Lifestyle changes, such as overeating and underexercising, can increase the risk of prediabetes. Diabetes is one of the leading causes of atherosclerosis, and recently it became clear that the pathophysiology of atherosclerosis progresses even before the onset of diabetic symptoms. In addition to changes in platelets and leukocytes in the hyperglycemic state and damage to vascular endothelial cells, extracellular vesicles and microRNAs were found to be involved in the progression of prediabetes atherosclerosis. This review discusses the cellular and molecular mechanisms of these processes, with an intention to enable a comprehensive understanding of the pathophysiology of prediabetes and atherosclerosis.
Special Issue “Molecular Mechanisms of Memory Formation and Modification”
Authors: Jarome Timothy J. , Kwapis Janine L.
Published: April 2021

Memory is vital to human functioning and controls future behavioral responses [...]
The Characterization of a Subependymal Giant Astrocytoma-Like Cell Line from Murine Astrocyte with mTORC1 Hyperactivation
Authors: Tang Xin , Angst Gabrielle , Haas Michael , Yang Fuchun , Wang Chenran
Published: April 2021

Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating mutations in TSC1 (hamartin) or TSC2 (tuberin), crucial negative regulators of the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway. TSC affects multiple organs including the brain. The neurologic manifestation is characterized by cortical tubers, subependymal nodules (SEN), and subependymal giant cell astrocytoma (SEGA) in brain. SEGAs may result in hydrocephalus in TSC patients and mTORC1 inhibitors are the current recommended therapy for SEGA. Nevertheless, a major limitation in the research for SEGA is the lack of cell lines or animal models for mechanistic investigations and development of novel therapy. In this study, we generated TSC1-deficient neural cells from spontaneously immortalized mouse astrocytes in an attempt to mimic human SEGA. The TSC1-deficient cells exhibit mTORC1 hyperactivation and characteristics of transition from astrocytes to neural stem/progenitor cell phenotypes. Rapamycin efficiently decreased mTORC1 activity of these TSC1-deficient cells in vitro. In vivo, TSC1-deficient cells could form SEGA-like tumors and Rapamycin treatment decreased tumor growth. Collectively, our study generates a novel SEGA-like cell line that is invaluable for studying mTORC1-driven molecular and pathological alterations in neurologic tissue. These SEGA-like cells also provide opportunities for the development of novel therapeutic strategy for TSC patients with SEGA.
Molecular Mechanisms of Atopic Dermatitis Pathogenesis
Authors: Sroka-Tomaszewska Jowita , Trzeciak Magdalena
Published: April 2021

Atopic dermatitis is a chronic, non-infectious inflammatory dermatosis. Acharacteristic feature is persistent itching of the skin. The chronic, relapsing course of the disease, economic burden, and the whole family’s involvement in the treatment process immensely reduce the quality of life of patients and their families. The disease emerges as a social problem by increasing indirect costs, such as visiting a doctor, absenteeism from work and school, and avoiding social interactions. Thepathophysiology of atopic dermatitis is complex and multifactorial. It includes genetic disorders, a defect in the epidermal barrier, an altered immune response, anddisruption of the skin’s microbial balance. The numerous complex changes at thegenetic level and innate and adaptive immunity provide the basis for characterizing the various phenotypes and endotypes of atopic dermatitis. Emerging therapies rely on the action of specific molecules involved in the disease’s pathogenesis. It may be the starting point for the individualization of atopic dermatitis treatment. This paper will try to present some molecular mechanisms of atopic dermatitis and their clinical implications.
Transgenerational Effects of Di(2-Ethylhexyl) Phthalate on Anogenital Distance, Sperm Functions and DNA Methylation in Rat Offspring
Authors: Hsu Ping-Chi , Jhong Jia-Ying , Huang Li-Ping , Lee Kuo-Hsin , Chen Hsin-Pao , Guo Yue-Leon
Published: April 2021

Di(2-ethylhexyl) phthalate (DEHP) is widely used as a plasticizer in the manufacture of polyvinylchloride plastics and has been associated with concerns regarding male reproductive toxicity. In this study, we hypothesized that maternal exposure to DEHP induces transgenerational inheritance of adult-onset adverse reproductive outcomes through the male germline in the F1, F2, and F3 generations of male offspring. Pregnant rats were treated with 5 or 500 mg of DEHP/kg/day through gavage from gestation day 0 to birth. The offspring body weight, anogenital distance (AGD), anogenital index (AGI), sperm count, motility, and DNA fragmentation index (DFI) were measured for all generations. Methyl-CpG binding domain sequencing was performed to analyze sperm DNA methylation status in the F3. DEHP exposure at 500 mg/kg affected AGD, AGI, sperm count, mean DFI, and %DFI in the F1; AGD, sperm count, and mean DFI in the F2; and AGD, AGI, mean DFI, and %DFI in the F3. DEHP exposure at 5 mg/kg affected AGD, AGI, sperm count, and %DFI in the F1; sperm count in the F2; and AGD and AGI in F3. Compared with the control group, 15 and 45 differentially hypermethylated genes were identified in the groups administered 5 mg/kg and 500 mg/kg DEHP, respectively. Moreover, 130 and 6 differentially hypomethylated genes were observed in the groups administered 5 mg/kg and 500 mg/kg DEHP. Overall, these results demonstrated that prenatal exposure to DEHP caused transgenerational epigenetic effects, which may explain the observed phenotypic changes in the male reproductive system.
TaCKX2.2 Genes Coordinate Expression of Other TaCKX Family Members, Regulate Phytohormone Content and Yield-Related Traits of Wheat
Authors: Jablonski Bartosz , Szala Karolina , Przyborowski Mateusz , Bajguz Andrzej , Chmur Magdalena , Gasparis Sebastian , Orczyk Waclaw , Nadolska-Orczyk Anna
Published: April 2021

TaCKX gene family members (GFMs) play essential roles in the regulation of cytokinin during wheat development and significantly influence yield-related traits. However, detailed function of most of them is not known. To characterize the role of TaCKX2.2 genes we silenced all homoeologous copies of both TaCKX2.2.1 and TaCKX2.2.2 by RNAi technology and observed the effect of silencing in 7 DAP spikes of T1 and T2 generations. The levels of gene silencing of these developmentally regulated genes were different in both generations, which variously determined particular phenotypes. High silencing of TaCKX2.2.2 in T2 was accompanied by slight down-regulation of TaCKX2.2.1 and strong up-regulation of TaCKX5 and TaCKX11, and expression of TaCKX1, TaCKX2.1, and TaCKX9 was comparable to the non-silenced control. Co-ordinated expression of TaCKX2.2.2 with other TaCKX GFMs influenced phytohormonal homeostasis. Contents of isoprenoid, active cytokinins, their conjugates, and auxin in seven DAP spikes of silenced T2 plants increased from 1.27 to 2.51 times. However, benzyladenine (BA) and abscisic acid (ABA) contents were significantly reduced and GA3 was not detected. We documented a significant role of TaCKX2.2.2 in the regulation of thousand grain weight (TGW), grain number, and chlorophyll content, and demonstrated the formation of a homeostatic feedback loop between the transcription of tested genes and phytohormones. We also discuss the mechanism of regulation of yield-related traits.
Chromeno[3,4-b]xanthones as First-in-Class AChE and Aβ Aggregation Dual-Inhibitors
Authors: Malafaia Daniela , Oliveira Ana , Fernandes Pedro A. , Ramos Maria J. , Albuquerque Hélio M. T. , Silva Artur M. S.
Published: April 2021

Alzheimer’s disease (AD) is a complex multifactorial disorder, mainly characterized by the progressive loss of memory and cognitive, motor, and functional capacity. The absence of effective therapies available for AD alongside the consecutive failures in the central nervous system (CNS) drug development has been motivating the search for new disease-modifying therapeutic strategies for this disease. To address this issue, the multitarget directed ligands (MTDLs) are emerging as a therapeutic alternative to target the multiple AD-related factors. Following this concept, herein we describe the design, synthesis, and biological evaluation of a family of chromeno[3,4-b]xanthones as well as their (E)-2-[2-(propargyloxy)styryl]chromone precursors, as first-in-class acetylcholinesterase (AChE) and β-amyloid (Aβ) aggregation dual-inhibitors. Compounds 4b and 10 emerged as well-balanced dual-target inhibitors, with IC50 values of 3.9 and 2.9 μM for AChE and inhibitory percentages of 70 and 66% for Aβ aggregation, respectively. The molecular docking showed that most of the compounds bound to AChE through hydrogen bonds with residues of the catalytic triad and π-stacking interactions between the main scaffold and the aromatic residues present in the binding pocket. The interesting well-balanced activities of these compounds makes them interesting templates for the development of new multitarget compounds for AD.
Maternal Heat Stress Alters Expression of Genes Associated with Nutrient Transport Activity and Metabolism in Female Placentae from Mid-Gestating Pigs
Authors: Zhao Weicheng , Liu Fan , Marth Christina D. , Green Mark P. , Le Hieu H. , Leury Brian J. , Bell Alan W. , Dunshea Frank R. , Cottrell Jeremy J.
Published: April 2021

Placental insufficiency is a known consequence of maternal heat stress during gestation in farm animals. The molecular regulation of placentae during the stress response is little known in pigs. This study aims to identify differential gene expression in pig placentae caused by maternal heat exposure during early to mid-gestation. RNA sequencing (RNA-seq) was performed on female placental samples from pregnant pigs exposed to thermoneutral control (CON; constant 20 °C; n = 5) or cyclic heat stress (HS; cyclic 28 to 33 °C; n = 5) conditions between d40 and d60 of gestation. On d60 of gestation, placental efficiency (fetal/placental weight) was decreased (p = 0.023) by maternal HS. A total of 169 genes were differentially expressed (FDR ≤ 0.1) between CON and HS placentae of female fetuses, of which 35 genes were upregulated and 134 genes were downregulated by maternal HS. The current data revealed transport activity (FDR = 0.027), glycoprotein biosynthetic process (FDR = 0.044), and carbohydrate metabolic process (FDR = 0.049) among the terms enriched by the downregulated genes (HS vs. CON). In addition, solute carrier (SLC)-mediated transmembrane transport (FDR = 0.008) and glycosaminoglycan biosynthesis (FDR = 0.027), which modulates placental stroma synthesis, were identified among the pathways enriched by the downregulated genes. These findings provide evidence that heat-stress induced placental inefficiency may be underpinned by altered expression of genes associated with placental nutrient transport capacity and metabolism. A further understanding of the molecular mechanism contributes to the identification of placental gene signatures of summer infertility in pigs.
Benchmarking Machine Learning Models to Assist in the Prognosis of Tuberculosis
Authors: Lino Ferreira da Silva Barros Maicon Herverton , Oliveira Alves Geovanne , Morais Florêncio Souza Lubnnia , da Silva Rocha Elisson , Lorenzato de Oliveira João Fausto , Lynn Theo , Sampaio Vanderson , Endo Patricia Takako
Published: April 2021

Tuberculosis (TB) is an airborne infectious disease caused by organisms in the Mycobacterium tuberculosis (Mtb) complex. In many low and middle-income countries, TB remains a major cause of morbidity and mortality. Once a patient has been diagnosed with TB, it is critical that healthcare workers make the most appropriate treatment decision given the individual conditions of the patient and the likely course of the disease based on medical experience. Depending on the prognosis, delayed or inappropriate treatment can result in unsatisfactory results including the exacerbation of clinical symptoms, poor quality of life, and increased risk of death. This work benchmarks machine learning models to aid TB prognosis using a Brazilian health database of confirmed cases and deaths related to TB in the State of Amazonas. The goal is to predict the probability of death by TB thus aiding the prognosis of TB and associated treatment decision making process. In its original form, the data set comprised 36,228 records and 130 fields but suffered from missing, incomplete, or incorrect data. Following data cleaning and preprocessing, a revised data set was generated comprising 24,015 records and 38 fields, including 22,876 reported cured TB patients and 1139 deaths by TB. To explore how the data imbalance impacts model performance, two controlled experiments were designed using (1) imbalanced and (2) balanced data sets. The best result is achieved by the Gradient Boosting (GB) model using the balanced data set to predict TB-mortality, and the ensemble model composed by the Random Forest (RF), GB and Multi-Layer Perceptron (MLP) models is the best model to predict the cure class.
UDP-Glycosyltransferases from the UGT344 Family Are Involved in Sulfoxaflor Resistance in Aphis gossypii Glover
Authors: Ma Kangsheng , Tang Qiuling , Liang Pingzhuo , Li Jianhong , Gao Xiwu
Published: April 2021

UDP-glycosyltransferases (UGTs) are major phase II detoxification enzymes that catalyze the transfer of glycosyl residues from activated nucleotide sugars to acceptor hydrophobic molecules and play very important roles in the biotransformation of various endogenous and exogenous compounds. Our previous studies demonstrated that UGTs participated in the detoxification of insecticides in Aphis gossypii. However, the potential roles of UGTs in A. gossypii resistance to sulfoxaflor are still unclear. In this study, two inhibitors of UGT enzymes, sulfinpyrazone and 5-nitrouracil, significantly increased the toxicity of sulfoxaflor to a resistant strain of A. gossypii, whereas there were no synergistic effects in the susceptible strain. Based on the transcriptome sequencing results, the expression levels of 15 UGTs were analyzed by quantitative real-time PCR, and we found that seven UGT genes were highly over-expressed in a sulfoxaflor-resistant strain compared to the susceptible strain, including UGT344B4, UGT344C5, UGT344A11, UGT344A14, and UGT344L2. Further suppressing the expression of UGT344B4, UGT344C5, and UGT344A11 by RNA interference significantly increased the sensitivity of resistant aphids to sulfoxaflor, indicating that the overexpression of UGT genes is potentially associated with sulfoxaflor resistance. These results could provide valuable information for further understanding the mechanisms of insecticide resistance.
Identifying Molecular-Based Trophic Interactions as a Resource for Advanced Integrated Pest Management
Authors: Schmidt Jason M. , Acebes-Doria Angelita , Blaauw Brett , Kheirodin Arash , Pandey Swikriti , Lennon Kylie , Kaldor Amos D. , Toledo Pedro F. S. , Grabarczyk Erin E.
Published: April 2021

Biodiversity is an essential attribute of sustainable agroecosystems. Diverse arthropod communities deliver multiple ecosystem services, such as biological control, which are the core of integrated pest management programs. The molecular analysis of arthropod diets has emerged as a new tool to monitor and help predict the outcomes of management on the functioning of arthropod communities. Here, we briefly review the recent molecular analysis of predators and parasitoids in agricultural environments. We focus on the developments of molecular gut content analysis (MGCA) implemented to unravel the function of community members, and their roles in biological control. We examine the agricultural systems in which this tool has been applied, and at what ecological scales. Additionally, we review the use of MGCA to uncover vertebrate roles in pest management, which commonly receives less attention. Applying MGCA to understand agricultural food webs is likely to provide an indicator of how management strategies either improve food web properties (i.e., enhanced biological control), or adversely impact them.
Biologically Inspired Intra-Uterine Nanofluid Flow under the Suspension of Magnetized Gold (Au) Nanoparticles: Applications in Nanomedicine
Authors: Bhatti Muhammad Mubashir
Published: April 2021

The present analysis deals with the intra-uterine nanofluid flow of a Jeffrey fluid through a finite asymmetric channel filled with gold nanoparticles. Gold nanoparticles are helpful in biomedicine to treat various diseases and locate blood flow motion through tiny vessels. The governing fluid is electrically conducting due to the presence of an extrinsic magnetic field while the magnetic Reynolds number is small; therefore, the induced magnetic effects are neglected. The thermal radiation and viscous dissipation effects are also contemplated with the energy equation. The lubrication approach has been utilized by taking a long wavelength and ignoring the inertial forces. The formulated equations are coupled and nonlinear; therefore, a perturbation approach is used to derive the series results. The results are obtained up to the second-order and plotted against various parameters for velocity mechanism, trapping profile, pressure rise, and temperature profile.