bluuebunny/crossref_metadata_2025 huggingface dataset:
Work-related challenges and their associated coping mechanisms among female head porters (Kayayei) in Ghana
Authors: Komesuor Joyce , Manu Emmanuel , Meyer-Weitz Anna
Published: July 2024

Background

While internal migrants (Kayayei) in Ghana have been perceived as a vulnerable group facing various health-related challenges, there has not been enough research on the impact of their work on their health and well-being. This study investigated the lived experiences of the Kayayei to identify the health-related challenges associated with their work and the coping mechanisms they adopt in dealing with these challenges.

Methods

We interviewed 21 participants purposely selected and conducted two focus group discussions (FGD) of five participants each at the Agbogbloshie market. Interpretive Phenomenology Analysis Approach was used to identify themes and sub-themes. Statements from participants were presented as quotes to corroborate their views.

Results

The work-related challenges identified in the study were physical health, mental health, accommodation, and social challenges. Religion, recreation, social support, hope, resilience, and self-medication were the coping strategies adopted by the study participants.

Conclusion

The government of Ghana should be encouraged to work with stakeholders like social welfare to raise awareness about women’s rights, build their skills to increase their employment opportunities, enhance their safety, health, and overall well-being. It is also important to ensure the networking of relevant stakeholders to work with women in the informal sector to foster agency and provide support when needed.
Decline in academic performance and mental health during the COVID-19 pandemic: a cross-sectional survey among Sapienza University of Rome students
Authors: Siena Leonardo Maria , Mussetto Ilaria , Renzi Erika , Baccolini Valentina , Migliara Giuseppe , Sciurti Antonio , Covelli Antonio , De Vito Corrado , Marzuillo Carolina , Villari Paolo , Massimi Azzurra
Published: July 2024

Introduction

The COVID-19 pandemic has posed significant challenges to the education system, leading to changes in student academic performance and mental health. The aim of this study was to evaluate variables relating to changes in academic performance and mental health during the pandemic.

Methods

We carried out a cross-sectional study from 28 February 2022 to 13 April 2022, during the free SARS-CoV-2 screening campaign offered by Sapienza University of Rome. A structured questionnaire was constructed to explore the decline in academic performance during the COVID-19 pandemic. The Coronavirus Anxiety Scale (CAS), a validated self-reporting mental health screener of dysfunctional anxiety associated with the coronavirus crisis, was used.

Results

A sample of 1,134 students was enrolled. A total of 25.4% of the participants reported a decline in academic performance. In addition, Coronavirus Anxiety Scale scores revealed that 133 (11.5%) students had a dysfunctional anxiety problem due to COVID-19. A multivariable logistic regression model showed that being a senior student (aOR: 0.70 95% CI: 0.52–0.96) and having good financial status (aOR: 0.64, 95% CI: 0.47–0.88) decrease the likelihood of a decline in academic performance, while not being Italian (aOR: 2.12, 95% CI: 1.29–3.48), having felt the need for psychological support (aOR: 2.58, 95% CI: 1.87–3.55) and being enrolled in a science/technology faculty (aOR: 1.81, 95% CI: 1.27–2.57) were more likely to result in a decline in academic performance.

Conclusion

Our results show that the pandemic has affected academic performance. The COVID-19 emergency highlighted the importance of considering mental health and economic status in policymaking to effectively support students.
Multiple impacts of the COVID-19 pandemic and antimicrobial stewardship on antimicrobial resistance in nosocomial infections: an interrupted time series analysis
Authors: Li Weibin , Yang Xinyi , Liu Chaojie , Liu Xu , Shi Lin , Zeng Yingchao , Xia Haohai , Li Jia , Zhao Manzhi , Yang Shifang , Li Xiaojie , Hu Bo , Yang Lianping
Published: July 2024

Objectives

The emergency response to the COVID-19 pandemic may disrupt hospital management activities of antimicrobial resistance (AMR). This study aimed to determine the changing AMR trend over the period in China when stringent COVID-19 response measures were implemented.

Methods

This retrospective study was conducted in a designated hospital for COVID-19 patients in Guangzhou, China from April 2018 to September 2021. The prevalence of 13 antimicrobial-resistant bacteria was compared before and after the COVID-19 responses through Chi-square tests. Interrupted time series (ITS) models on the weekly prevalence of AMR were established to determine the changing trend. Controlled ITS models were performed to compare the differences between subgroups.

Results

A total of 10,134 isolates over 1,265 days were collected. And antimicrobial-resistant strains presented in 38.6% of the testing isolates. The weekly AMR prevalence decreased by 0.29 percentage point (95% CI [0.05–0.80]) after antimicrobial stewardship (AMS) policy, despite an increase in the prevalence of penicillin-resistant Streptococcus pneumoniae (from 0/43 to 15/43, p < 0.001), carbapenem-resistant Escherichia coli (from 20/1254 to 41/1184, p = 0.005), and carbapenem-resistant Klebsiella pneumoniae (from 93/889 to 114/828, p = 0.042). And the changing trend did not vary by gender (male vs. female), age (<65 vs. ≥65 years), service setting (outpatient vs. inpatient), care unit (ICU vs. non-ICU), the primary site of infection (Lung vs. others), and Gram type of bacteria (positive vs. negative).

Conclusion

The response to COVID-19 did not lead to an increase in overall AMR; however, it appears that management strategy on the prudent use of antimicrobials likely contributed to a sizable long-term drop. The frequency of several multidrug-resistant bacteria continues to increase after the COVID-19 epidemic. It is crucial to continue to monitor AMR when COVID-19 cases have surged in China after the relaxation of restriction measures.
Value of interventional radiology and their contributions to modern medical systems
Authors: Campbell Warren A. , Chick Jeffrey F. B. , Shin David S. , Makary Mina S.
Published: July 2024

Interventional radiology (IR) is a unique specialty that incorporates a diverse set of skills ranging from imaging, procedures, consultation, and patient management. Understanding how IR generates value to the healthcare system is important to review from various perspectives. IR specialists need to understand how to meet demands from various stakeholders to expand their practice improving patient care. Thus, this review discusses the domains of value contributed to medical systems and outlines the parameters of success. IR benefits five distinct parties: patients, practitioners, payers, employers, and innovators. Value to patients and providers is delivered through a wide set of diagnostic and therapeutic interventions. Payers and hospital systems financially benefit from the reduced cost in medical management secondary to fast patient recovery, outpatient procedures, fewer complications, and the prestige of offering diverse expertise for complex patients. Lastly, IR is a field of rapid innovation implementing new procedural technology and techniques. Overall, IR must actively advocate for further growth and influence in the medical field as their value continues to expand in multiple domains. Despite being a nascent specialty, IR has become indispensable to modern medical practice.
The Tiny Brains of Wasps Can Learn and Remember Information
Authors: da Silva Rafael Carvalho , Aguiar João Marcelo Robazzi Bignelli Valente , Oi Cintia Akemi , Batista Jaqueline Eterna , do Nascimento Fabio Santos , Giurfa Martin
Published: July 2024

If you have a garden, you have probably seen many insects flying around looking for food. Despite having miniature brains, these small creatures can learn and memorize flower features, mainly colors and smells, which they associate with nectar and pollen (their food) provided by the flowers. Honeybees are not the only pollinators in nature—wasps also pollinate flowers, but less is known about them. We studied whether wasps could learn and memorize information. We developed a study to investigate whether wasps could learn to associate a flowery smell with sugary water. We found that female and male wasps have powerful learning and memory abilities, which are important for their daily social lives.
Persistence and activity levels of primitive reflexes in young high-level football players
Authors: Bastiere Julie , Lussiana Thibault , Young Damien , Gindre Cyrille , Mourot Laurent
Published: July 2024

Introduction

Primitive reflexes (PR) induce involuntary automatic movements in response to specific stimuli. This study aimed to determine the prevalence of active PR in young high-level football players.

Methodology

Sixty-nine national-level football players from a French academy were tested (17.0 ± 1.4 years; 69.6 ± 8.0 kg; 178.9 ± 6.9 cm) to evaluate the persistence of PR, following the methodology of the Institute for Neuro-Physiological Psychology (INPP) and the classification by a global score (GS). Based on the sum of seven tests, each was rated between 0 = null and 4 = max. The GS is classified into five categories from no activity to maximal (0–1 = no activity, 2–7 = low, 8–13 = medium, 14–21 = high, and 22–28 = maximal).

Result

Around two-thirds (68.1%) of players presented active PR at different activity levels. Among them, a small proportion (7.2%) had medium GS, while 60.9% had a low GS. The GS was not dependent on field position or the age of the players (p > 0.05). However, playing football in an age category higher than their own was associated with significantly more active primitive reflexes (PR) compared to being in their age category (p < 0.01). The results showed that 72.7% of “upgraded” football players had low GS and 18.2% had medium GS, compared to 55.3% and 2.1% in the non-upgraded group.

Discussion

The findings of the current study demonstrate that PR could still be active in a healthy population of high-level football players. Practicing a single sport for years and upgrading players could create a negative environment that can ultimately lead to the activation of otherwise integrated PR.
Career trajectories, transition rates, and birthdate distributions: the rocky road from youth to senior level in men's European football
Authors: Brustio Paolo Riccardo , McAuley Alexander B. T. , Ungureanu Alexandru Nicolae , Kelly Adam Leigh
Published: July 2024

This study aimed to assess youth-to-senior transition rates, quantify the magnitude of relative age effect (RAEs), and evaluate how RAEs affect these transitions in 9,527 men's national football players of England, France, Germany, Italy, and Spain. Regardless of national team, only −15%, 25%, and 40% of U17, U19, and U21 players successfully transitioned to the senior team, respectively, whilst −14%–24% progressed to senior level without being selected during youth. Data suggested a skewed birthdate distribution favouring relatively older players at U17, U19, and U21 levels across all countries, whereas RAEs were also present in England, Italy, and Spain at senior level. Youth-to-senior transition rates were modulated by birthdate at U17 and U19, whereby Q4 players were −2 and 1.5 times more likely to successfully transition at senior level than Q1 players, respectively. Selection at youth international level does not guarantee selection at senior level, but does make it more likely. Moreover, relatively younger athletes are disadvantaged in youth categories, although are more likely to transition to senior level once they have entered the pathway.
The coproduction of a multilevel personal narrative intervention for people with aphasia in a community communication support group—A pilot study
Authors: Charalambous Marina , Symeou Rafaella Tereza , Theodorou Elena , Kambanaros Maria
Published: July 2024

Introduction

People with aphasia (PWA) face challenges in sharing personal stories due to communication difficulties. Discourse treatment in aphasia focusing on personal narrative macrostructure has yet to receive the attention this warrants of researchers and clinicians. Emerging person-centered approaches involve coproduction and codesign with PWA for meaningful discourse treatments. Few studies explore discourse treatment's impact on functional communication. This pilot study aims to explore whether the use of the coproduction approach in the development of a multilevel personal narrative intervention at the group level increased the production of macrostructure elements in trained and untrained narrative discourse contexts, improved aphasia severity and functional communication skills, and advanced quality of life of the participants with aphasia.

Methods

An ABA design was followed featuring a pre-treatment baseline assessment phase, a treatment phase, and a post-treatment assessment phase immediately after treatment was completed. Three people with chronic stroke-induced aphasia, three communication partners, and a moderator took part in the study. All participants were members of a university-led community aphasia communication group. The research protocol consisted of eleven, two-hour, weekly sessions over an 11-week block. Nine treatment sessions were carried out following codesign and coproduction methods that focused on participants with aphasia producing words, sentences, and total communication strategies to express macrostructure elements in their personal stories. Assessment measures were collected at baseline and post-treatment to evaluate improvements in trained and untrained narrative abilities, aphasia severity, functional communication, and the impact of aphasia on quality of life.

Results

Multilevel personal narrative therapy improved the narrative skills of the participants with aphasia at the macrostructural level of narrative discourse. Improvements were also observed in functional communication and quality of life post-treatment.

Discussion

The involvement of participants with aphasia in the codesign and coproduction of the treatment content for the group intervention facilitated improvement in narrative skills, functional communication, and overall quality of life with aphasia. It is recommended that researchers and clinicians consider using content from the personal narratives of clients with aphasia to build discourse treatment and adopt codesign and coproduction approaches, when designing interventions for people with chronic aphasia, to improve communication outcomes in everyday life.
Antibiotic use in Uganda’s livestock-keeping households: prevalence, patterns, and determinants
Authors: Kibooga Charity , Nakiyemba Constance , Asiimwe Robert
Published: July 2024

Livestock farming is vital to global food systems, but the misuse of antibiotics in this sector has raised concerns about its role in the emergence of antimicrobial resistance - now a public health issue. Addressing the misuse of antibiotics requires an understanding of usage patterns and determinants among livestock farmers. This study investigated antibiotic use among livestock farmers in Uganda, examining the frequency of use and factors influencing usage with data from the 2018 Uganda Annual Agricultural Survey. Descriptive results showed that on average one in every three livestock keepers had used antibiotics in the previous year, with 15% of them using antibiotics at least every month in the previous year. Regression analysis results revealed that, among other factors, production systems (keeping cattle, keeping exotic livestock, and herd size) and keepers’ perceptions of the continued efficacy of antibiotics in controlling target diseases even with continuous use significantly influenced the decision to use antibiotics and the frequency with which they were used. The results of this study confirmed the growing concern that antibiotic use in Uganda is no longer limited to humans but has significantly expanded to the livestock sector too. The results further affirmed that antibiotic use in livestock production has reached significant levels that require streamlining from a public health perspective. The study recommends strengthening veterinary education and increasing public awareness of appropriate antibiotic use to combat wrong perceptions towards antibiotic use and encourage safe use.
Public Willingness to Pay for Farmland Eco-Compensation and Allocation to Farmers: An Empirical Study from Northeast China
Authors: Liu Baoqi , Xu Lishan , Long Yulin , Wei Yuehua , Ao Changlin
Published: July 2024

Farmland eco-compensation, as a typical payment for ecosystem services scheme, aims to address trade-offs between environmental and developmental objectives. As indispensable eco-compensation supporters, the public’s willingness to pay (WTP) for farmland eco-compensation and the allocation to farmers directly affect ecological safety and sustainable development for farmland. Therefore, this study links the public’s WTP for the farmland eco-compensation to the financial subsidies received by farmers and presents a theoretical framework and research approach that connects stakeholders, applying improved choice experiments for empirical study in the black soil region of northeastern China. The results showed that the public has a positive WTP for the farmland eco-compensation program that improves the area, soil thickness, and organic content expeditiously. The public’s WTP allocation for eco-compensation varies considerably, with the share allocated to farmers in their WTP averaging 46.96%, showing a benchmark for compensation standards. The results revealed the influential relationship between the socioeconomic characteristics of the public with WTP allocation and the preferences for farmland eco-compensation, such as the positive correlation between age with WTP allocation and females’ greater preference for eco-compensation. These findings can provide new perspectives and approaches to exploring sustainable pathways for farmland eco-compensation.
Design and Experiment of In-Situ Bionic Harvesting Device for Edible Sunflower
Authors: Zhu Xuefeng , Xu Yang , Han Changjie , You Jia , Zhang Xuejun , Mao Hanping , Ma Xu
Published: July 2024

In view of the low degree of mechanization and poor quality of harvesting of edible sunflower after drying, an in situ bionic harvesting device was designed, which can achieve low-loss harvesting of edible sunflower without removing the edible sunflower disc. According to the physical characteristics of sunflower stalks in the field, influencing factors of in situ low-loss feeding were obtained, and the structural parameters of the in situ feeding mechanism were determined. Based on bionic technology and static analysis, the influencing factors on the performance of the bionic threshing mechanism were obtained. By analyzing the mechanical characteristics of edible sunflower seed, the operation parameters of the seed collection mechanism were determined. Based on the structural analysis results of the harvesting device, a response surface optimization test was carried out. The test results show that when the average rotation speed of the bionic loosening roller was 113.57 rpm, the average rotation speed of the simulated artificial striking roller was 230.80 rpm, the average forward speed of the harvesting device was 0.58 m/s, the working quality of the harvesting device was the best, the seed loss rate was 2.12%, and the edible sunflower disc threshing rate was 98.96%. A field verification test further confirms that under the optimal working parameters, the relative deviation between test indexes and response surface optimization test results was less than 2%. During the operation process, the movement of key components of the harvesting device was coordinated and stable. The research results can provide new ideas for the mechanized harvesting of the edible sunflower disc after drying.
Antimicrobial Resistance in the WHO African Region: A Systematic Literature Review 2016–2020
Authors: Gahimbare Laetitia , Muvunyi Claude Mambo , Guessennd Nathalie Aya Kouadio , Rutanga Jean Pierre , Gashema Pierre , Fuller Walter , Mwamelo Ambele Judith , Coulibaly Sheick Oumar , Mosha Fausta Shakiwa , Perovic Olga , Tali-Maamar Hassiba , Yahaya Ali Ahmed
Published: July 2024

Antimicrobial resistance (AMR) is a significant global public health threat. This review presents the most recent in-depth review of the situation of the main AMR types in relation to the most commonly prescribed antibiotics in the World Health Organization (WHO) African Region. Underlying genes of resistance have been analyzed where possible. A search to capture published research data on AMR from articles published between 2016 and 2020 was done using PubMed and Google Scholar, with rigorous inclusion/exclusion criteria. Out of 48003 articles, only 167 were included. Among the tested gram-negative bacteria species, Klebsiella spp. remain the most tested, and generally the most resistant. The highest overall phenotypic resistance for imipenem was reported in E. coli, whereas for meropenem, E. coli and Haemophilus spp. showed an equal resistance proportion at 2.5%. For gram-positive bacteria, Streptococcus pneumoniae displayed high resistance percentages to trimethoprim/sulfamethoxazole (64.3%), oxacillin (32.2%), penicillin (23.2%), and tetracycline (28.3%), whereas Staphylococcus aureus contributed to 22.8% and 10% resistance to penicillin and oxacillin, respectively. This review shows that AMR remains a major public health threat. The present findings will help public health decision-makers in developing efficient preventive strategies and adequate policies for antibiotic stewardship and surveillance in line with the global action plan for AMR.
A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective
Authors: Donkor Eric S. , Odoom Alex , Osman Abdul-Halim , Darkwah Samuel , Kotey Fleischer C. N.
Published: July 2024

Background: Antimicrobial resistance (AMR) poses a global health threat, with lower-middle-income countries bearing a disproportionate burden. Surveillance of AMR under a One Health framework is needed to elucidate the associations among clinical, animal, and environmental AMR. This review aimed to describe the state of AMR in Ghana, focusing on One Health. Method: This review utilized the PRISMA guidelines and major databases to systematically search and analyze AMR in Ghana published from 1 January 2014 to 1 May 2023. Results: Out of the 48 articles that met the inclusion criteria, 28 studies were conducted on humans, 14 studies involved animals, and 6 studies focused on the environment. A total of 48 different pathogens were identified across the human, animal, and environmental sectors, with the most common being Escherichia coli (67%, n = 32), Klebsiella spp. (52%, n = 25), Pseudomonas spp. (40%, n = 19), and Salmonella spp. (38%, n = 18). Generally, a high prevalence of antibiotic resistance was observed among various bacterial species across the sectors. These bacteria exhibited resistance to commonly used antibiotics, with resistance to ampicillin and tetracycline exceeding 80%, and multidrug resistance (MDR) ranging from 17.6% in Shigella spp. to 100% in Acinetobacter spp. Conclusion: This review reaffirms the significant challenge of AMR in Ghana, with a high prevalence observed in the human, animal, and environmental sectors. Key pathogens (e.g., Staphylococcus aureus and Escherichia coli) found across the sectors emphasize the urgent need for a One Health approach to tackle AMR in Ghana.
Thermal-Responsive Antibacterial Hydrogel with Photothermal Therapy and Improving Wound Microenvironment for Promote Healing
Authors: Huang Linjie , Deng Jingwen , Su Yina , Hu Xueqi , Zhang Yichao , Hong Shanni , Lin Xiahui
Published: July 2024

Skin damage is one of the most prevalent human injuries, which affects the health of human beings. However, skin damage is often accompanied by bacterial infection and wound microenvironment changes, causing damage to normal cells and inhibiting wound healing. Herein, we designed a thermal-responsive antibacterial hydrogel (GAG hydrogel) loaded with catalase (CAT)-like Au@Pt@MgSiO3 nanoparticles (APM NPs) and gentamicin (GM) to promote wound healing. The GAG hydrogel was used in a photothermal therapy (PTT)/antibiotic combination to kill bacteria, reduce the use of antibiotics, improve the wound microenvironment, promote cell proliferation, and accelerate wound healing. Under near-infrared laser irradiation, APM NPs in the hydrogel generated local hyperthermia to kill bacteria. Meanwhile, the generated heat led to a change in the hydrogel’s morphology, enabling it to release GM and APM NPs to prevent the overuse of antibiotics. Subsequently, the CAT-like ability of the APM NPs decreased the oxidative stress caused by hydrogen peroxide (H2O2), thus remodeling the wound microenvironment. Then, the weakly acidic microenvironment of the wound caused the decomposition of the APM NPs and the release of magnesium ions (Mg2+), promoting the growth and migration of cells for wound healing. Therefore, the studied thermal-responsive antibacterial (GAG) hydrogel has potential in the field of wound healing.
HLFSRNN-MIL: A Hybrid Multi-Instance Learning Model for 3D CT Image Classification
Authors: Chen Huilong , Zhang Xiaoxia
Published: July 2024

At present, many diseases are diagnosed by computer tomography (CT) image technology, which affects the health of the lives of millions of people. In the process of disease confrontation, it is very important for patients to detect diseases in the early stage by deep learning of 3D CT images. The paper offers a hybrid multi-instance learning model (HLFSRNN-MIL), which hybridizes high-low frequency feature fusion (HLFFF) with sequential recurrent neural network (SRNN) for CT image classification tasks. Firstly, the hybrid model uses Resnet-50 as the deep feature. The main feature of the HLFSRNN-MIL lies in its ability to make full use of the advantages of the HLFFF and SRNN methods to make up for their own weakness; i.e., the HLFFF can extract more targeted feature information to avoid the problem of excessive gradient fluctuation during training, and the SRNN is used to process the time-related sequences before classification. The experimental study of the HLFSRNN-MIL model is on two public CT datasets, namely, the Cancer Imaging Archive (TCIA) dataset on lung cancer and the China Consortium of Chest CT Image Investigation (CC-CCII) dataset on pneumonia. The experimental results show that the model exhibits better performance and accuracy. On the TCIA dataset, HLFSRNN-MIL with Residual Network (ResNet) as the feature extractor achieves an accuracy (ACC) of 0.992 and an area under curve (AUC) of 0.997. On the CC-CCII dataset, HLFSRNN-MIL achieves an ACC of 0.994 and an AUC of 0.997. Finally, compared with the existing methods, HLFSRNN-MIL has obvious advantages in all aspects. These experimental results demonstrate that HLFSRNN-MIL can effectively solve the disease problem in the field of 3D CT images.
Strategies of Automated Machine Learning for Energy Sustainability in Green Artificial Intelligence
Authors: Castellanos-Nieves Dagoberto , García-Forte Luis
Published: July 2024

Automated machine learning (AutoML) is recognized for its efficiency in facilitating model development due to its ability to perform tasks autonomously, without constant human intervention. AutoML automates the development and optimization of machine learning models, leading to high energy consumption due to the large amount of calculations involved. Hyperparameter optimization algorithms, central to AutoML, can significantly impact its carbon footprint. This work introduces and investigates energy efficiency metrics for advanced hyperparameter optimization algorithms within AutoML. These metrics enable the evaluation and optimization of an algorithm’s energy consumption, considering accuracy, sustainability, and reduced environmental impact. The experimentation demonstrates the application of Green AI principles to AutoML hyperparameter optimization algorithms. It assesses the current sustainability of AutoML practices and proposes strategies to make them more environmentally friendly. The findings indicate a reduction of 28.7% in CO2e emissions when implementing the Green AI strategy, compared to the Red AI strategy. This improvement in sustainability is achieved with a minimal decrease of 0.51% in validation accuracy. This study emphasizes the importance of continuing to investigate sustainability throughout the life cycle of AI, aligning with the three fundamental pillars of sustainable development.
Study on the Properties and Fatigue Characteristics of Glass Fiber Composites Due to Porosity
Authors: Lee Haseung , Cho Younggen , Park Hyunbum
Published: July 2024

A study was conducted on the changes in mechanical properties and fatigue failure characteristics due to voids, one of the fabrication defects in composite materials. This study was primarily based on glass fiber fabrics applied to wind turbine blades and their material properties were predicted through micro and meso modeling of composite materials by simulating random defects including voids. As the wind turbine blades become larger, various defects develop. The fundamental changes in the materials’ properties due to voids were predicted through homogenization methods and Representative Volume Element (RVE), and the failure properties were obtained through progressive failure analysis by applying virtual coupons according to ASTM D3090 and ASTM D6641. The progressive failure was identified using the Matzenmiller–Lubliner–Taylor (MLT) failure condition, and the fatigue failure characteristics were assessed through the Tsai–Hill 3D load.
On Perceiving Molecular Time: Computational Chemical Simulations and the Moving Image
Authors: Rassell Andrea
Published: July 2024

The perception of time undergoes a radical shift between the human scale and the nanoscale. In an age of rapidly evolving media and scientific technologies, we need to understand how these impact human perception and visual culture. This essay explores computational molecular simulations through the lenses of temporal media theory and moving image practice. Emerging from a creative fellowship with a physical chemistry research group, I focus on two moving image works that depict crystalline structures. One is a nanoscale computational simulation of soot formation and the other is a durational video artwork showing the dissolution of sugar. Computational molecular simulations are shown to produce a feeling of time by smearing an extremely short duration across a longer perceptible duration. This analysis uncovers how the awareness of media as a construct troubles our chronoception (perception of time), while unexpectedly, the screen becomes complicit in scientists’ expert temporal understanding. The videos present vastly different spatial and temporal scales and have different chronoceptive effects: one gives a sense of being within time, the other across time. Ultimately, computational simulations emerge as isomorphic media that have explicit aesthetic properties that connect us to the implicit, abstract energetics of chemical reactivity.
On the Potential Vector Fields of Soliton-Type Equations
Authors: Blaga Adara M.
Published: July 2024

We highlight some properties of a class of distinguished vector fields associated to a (1,1)-tensor field and to an affine connection on a Riemannian manifold, with a special view towards the Ricci vector fields, and we characterize them with respect to statistical, almost Kähler, and locally product structures. In particular, we provide conditions for these vector fields to be closed, Killing, parallel, or semi-torse forming. In the gradient case, we give a characterization of the Euclidean sphere. Among these vector fields, the Ricci and torse-forming-like vector fields are particular cases.
Pulsing Addition to Modulated Electro-Hyperthermia
Authors: Szasz Andras
Published: July 2024

Numerous preclinical results have been verified, and clinical results have validated the advantages of modulated electro-hyperthermia (mEHT). This method uses the nonthermal effects of the electric field in addition to thermal energy absorption. Modulation helps with precisely targeting and immunogenically destroying malignant cells, which could have a vaccination-like abscopal effect. A new additional modulation (high-power pulsing) further develops the abilities of the mEHT. My objective is to present the advantages of pulsed treatment and how it fits into the mEHT therapy. Pulsed treatment increases the efficacy of destroying the selected tumor cells; it is active deeper in the body, at least tripling the penetration of the energy delivery. Due to the constant pulse amplitude, the dosing of the absorbed energy is more controllable. The induced blood flow for reoxygenation and drug delivery is high enough but not as high as increasing the risk of the dissemination of malignant cells. The short pulses have reduced surface absorption, making the treatment safer, and the increased power in the pulses allows the reduction of the treatment time needed to provide the necessary dose.
Impact of Iron Oxide on Anaerobic Digestion of Frass in Biogas and Methanogenic Archaeal Communities’ Analysis
Authors: Dong Xiaoying , Dong Aoqi , Liu Juhao , Qadir Kamran , Xu Tianping , Fan Xiya , Liu Haiyan , Ji Fengyun , Xu Weiping
Published: July 2024

With the increasing prominence of the global energy problem, socioeconomic activities have been seriously affected. Biofuels, as a renewable source of energy, are of great significance in promoting sustainable development. In this study, batch anaerobic digestion (AD) of frass (swine manure after bioconversion by black soldier fly larvae) and co-digestion with corn straw after the addition of iron oxide (Fe3O4) nanoparticles is investigated, as well as the start-up period without inoculation. The biochemical methane potential of pure frass was obtained using blank 1 group and after the addition of various sizes of Fe3O4 nanoparticles for 30 days period, and similarly, the digestion of frass with straw (blank 2) and after the addition of various sizes of Fe3O4 nanoparticles for 61 days period. The results showed that the average gas production was 209.43 mL/gVS, 197.68 mL/gVS, 151.85 mL/gVS, and 238.15 mL/gVS for the blank, ~176 nm, ~164 nm, and ~184 nm, respectively. The average gas production of frass with straw (blank 2) was 261.64 mL/gVS, 259.62 mL/gVS, 241.51 mL/gVS, and 285.98 mL/gVS for blank 2, ~176 nm, ~164 nm, and ~184 nm, respectively. Meanwhile, the accumulated methane production of the ~184 nm group was 2312.98 mL and 10,952.96 mL, respectively, which significantly increased the biogas production compared to the other groups. The methanogenic results of the frass (30 days) indicated that Methanocorpusculum, Methanosarcina, and Methanomassiliicoccus are the important methanogenic species in the AD reactor, while the microbial diversity of the ~184 nm group was optimal, which may be the reason for the high gas production of ~184 nm.
Research Progress on Starfish Outbreaks and Their Prevention and Utilization: Lessons from Northern China
Authors: Qu Liang , Sun Yongxin , Zhao Chong , Elphick Maurice R. , Wang Qingzhi
Published: July 2024

Starfish are keystone species as predators in benthic ecosystems, but when population outbreaks occur, this can have devastating consequences ecologically. Furthermore, starfish outbreaks and invasions can have adverse impact economically by impacting shellfish aquaculture. For example, an infestation of starfish in Qingdao led to a 50% reduction in sea cucumber production and an 80% reduction in scallop production, resulting in an economic loss of approximately RMB 100 million to oyster and other shellfish industries. Addressing the imperative need to proactively mitigate starfish invasions requires comprehensive research on their behavior and the underlying mechanisms of outbreaks. This review scrutinizes the historical patterns of outbreaks among diverse starfish species across various regions, delineates the factors contributing to the proliferation of Asterias amurensis in Chinese waters, articulates preventive and remedial strategies, and outlines the potential for the sustainable utilization of starfish.
Analysis of the Distribution Pattern of Phenacoccus manihoti in China under Climate Change Based on the Biomod2 Model
Authors: Huang Yumeng , Li Tong , Chen Weijia , Zhang Yuan , Xu Yanling , Guo Tengda , Wang Shuping , Liu Jingyuan , Qin Yujia
Published: July 2024

The changing global climate has significantly impacted the spread of plant pests. The cassava mealybug (Phenacoccus manihoti) is among the most dangerous quarantine pests affecting cassavas worldwide, causing substantial losses in agricultural production and food security across several regions. Although China is currently free of the cassava mealybug, its proximity to affected countries and extensive trade with these regions necessitate a detailed understanding of the pest’s distribution pattern and dynamic ecological niche changes. Using the Biomod2 model, we selected two historical climate scenarios and two future climate scenarios (SSP1-2.6 and SSP5-8.5) to investigate the distribution patterns, potential habitats, distribution centers, and dynamic ecological niches of cassava mealybugs in China. Key environmental variables influencing the distribution were identified, including bio4, bio8, bio12, bio18, and bio19. The potential habitat of cassava mealybugs is mainly located in several provinces in southern China. In the future, the suitable habitat is projected to expand slightly under the influence of climate change, maintaining the overall trend, but the distribution center of suitable areas will shift northward. Dynamic ecological niche prediction results indicate the potential for further expansion; however, the ecological niches may be unequal and dissimilar in the invaded areas. The predictions could serve as a valuable reference for early warning systems and management strategies to control the introduction of cassava mealybugs.
Can Vitamin D Supplementation Improve Inflammation in Relapsing-Remitting Multiple Sclerosis Patients?
Authors: Lis Martyna , Niedziela Natalia , Adamczyk-Zostawa Jowita , Wierzbicki Krzysztof , Czuba Zenon , Zalejska-Fiolka Jolanta , Bartman Wojciech , Świętek Agata , Adamczyk-Sowa Monika
Published: July 2024

(1) Background: Studies indicate that vitamin D (VitD) may reduce inflammation in multiple sclerosis (MS). The aim of the study was to assess the effect of supplementation with different doses of VitD on inflammation in relapsing-remitting MS (RRMS) patients. (2) Methods: The effect of 6-month supplementation with different doses of oral VitD (2000 IU/day) in a high-dose group (HD, n = 23) and a low-dose group (15,960 IU/month) (LD, n = 29) on selected markers of inflammation was assessed in 52 RRMS patients. (3) Results: Females constituted the majority of participants (63.46%). The median age [years] was 39.5 [34.5–49.8] and 47 [40.0–55.0] in the HD and LD groups, respectively. Significant differences were observed in age (p = 0.028), body weight (p = 0.014) and height (p = 0.001) between the study groups. Considering the BMI, statistically significant differences were not found (p = 0.496). The median 25(OH)D concentration [ng/mL] increased from 23.023 [15.578–25.76] in the HD group and 28.318 [20.644–32.232] in the LD group to 29.819 [24.937–38.064] and 30.837 [25.382–36.789], respectively (p < 0.01), and the increase was significantly higher in the HD group (p = 0.01). Hypovitaminosis D was found in most patients (71.2%) initially, and serum VitD levels were still <30.0 ng/mL in 46.2% of the participants at the follow-up. A significant increase in the levels of IL-4, IL-6, IL-17A, IL-22, IL-23 and TNF -α [pg/mL] and a decrease in IL-10 levels were reported during the study (p < 0.01). A significant positive correlation was observed between 25(OH)D serum levels and sCD40L (R = 0.33; p < 0.05) and TNF-α (R = 0.28; p < 0.05), and a significant negative correlation was reported between 25(OH)D and IL-23 (R = −0.32; p < 0.01) at the beginning of the study. (4) Conclusions: In RRMS patients, the doses of VitD were probably too low to induce beneficial effects on inflammation. Further studies are warranted to determine the effect of VitD supplementation on inflammatory markers in MS patients.
Instant and Multifunctional Nanofibers Loaded with Proanthocyanidins and Hyaluronic Acid for Skincare Applications
Authors: Yang Xuan , Gu Pengcheng , Jiang Qiang , Cheng Xiting , Fan Jia , Bai Yan
Published: July 2024

Hyaluronic-acid- and silk-fibroin-based nanofibrous mats loaded with proanthocyanidins and collagen peptides were fabricated as multifunctional facial masks using electrospinning. Their morphology, hygroscopicity and moisture retention, DPPH, ABTS free radical scavenging abilities, and cytocompatibility were investigated. The results showed that the nanofibrous mats were dense and uniform, with an average diameter ranging from 300 to 370 nm. The nanofibrous mats exhibited satisfactory moisture retention, oxidation resistance, biocompatibility, especially excellent DPPH, and ABTS free radical scavenging capacities. DPPH free radical scavenging activity was 90% with 15 mg/L nanofibers, and ABTS free radical scavenging activity was 90% with 0.005 mg/L nanofibers. The nanofibrous mats protected fibroblasts from oxidative stress damage induced by tert-butyl hydroperoxide (t-BHP) and significantly promoted their proliferation. Compared with traditional liquid masks and semi-solid facial masks, the multifunctional nanofibrous mats prepared in this study contained fewer additives, which has significant advantages in terms of safety. The nanofibrous mats were rapidly dissolved within 5 s after being sprayed with water, which facilitated the release and penetration of active ingredients for skincare. Therefore, the multifunctional nanofibrous mats displayed excellent moisture retention, oxidation resistance, and biocompatibility, indicating promising translational potential as facial masks and providing a valuable reference for skincare.
Exploring Symptom Overlaps: Post-COVID-19 Neurological Syndrome and Post-Concussion Syndrome in Athletes
Authors: Mavroudis Ioannis , Petridis Foivos , Petroaie Antoneta Dacia , Ciobica Alin , Kamal Fatima Zahra , Honceriu Cezar , Iordache Alin , Ionescu Cătălina , Novac Bogdan , Novac Otilia
Published: July 2024

The COVID-19 pandemic has introduced new challenges in managing neurological conditions, particularly among athletes. This paper explores the intersection of post-COVID-19 neurological syndrome (PCNS/PASC) and post-concussion syndrome (PCS), focusing on their implications in sports medicine. Our analysis covers the symptomatology, pathophysiology, and management strategies for PCNS/PASC and PPCS, with special attention paid to the unique challenges faced by athletes recovering from these conditions, including the risk of symptom exacerbation and prolonged recovery. Key findings reveal that both PCNS/PASC and PPCS present with overlapping symptoms such as cognitive difficulties, exercise intolerance, and mental health issues, but differ in specific manifestations like anosmia and ageusia, unique to COVID-19. Pathophysiological analysis reveals similarities in blood–brain barrier disruption (BBB) but differences in the extent of immune activation. Management strategies emphasize a gradual increase in physical activity, close symptom monitoring, and psychological support, with a tailored approach for athletes. Specific interventions include progressive aerobic exercises, resistance training, and cognitive rehabilitation. Furthermore, our study highlights the importance of integrating neurology, psychiatry, physical therapy, and sports medicine to develop comprehensive care strategies. Our findings underscore the dual challenge of COVID-19 and concussion in athletes, necessitating a nuanced, interdisciplinary approach to effective management. Future research should focus on the long-term neurological effects of both conditions and optimizing treatment protocols to improve patient outcomes. This comprehensive understanding is crucial for advancing the management of athletes affected by these overlapping conditions and ensuring their safe return to sports.
Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
Authors: Hirano Shin-ichi , Takefuji Yoshiyasu
Published: July 2024

While drug therapy plays a crucial role in cancer treatment, many anticancer drugs, particularly cytotoxic and molecular-targeted drugs, cause severe side effects, which often limit the dosage of these drugs. Efforts have been made to alleviate these side effects by developing derivatives, analogues, and liposome formulations of existing anticancer drugs and by combining anticancer drugs with substances that reduce side effects. However, these approaches have not been sufficiently effective in reducing side effects. Molecular hydrogen (H2) has shown promise in this regard. It directly reduces reactive oxygen species, which have very strong oxidative capacity, and indirectly exerts antioxidant, anti-inflammatory, and anti-apoptotic effects by regulating gene expression. Its clinical application in various diseases has been expanded worldwide. Although H2 has been reported to reduce the side effects of anticancer drugs in animal studies and clinical trials, the underlying molecular mechanisms remain unclear. Our comprehensive literature review revealed that H2 protects against tissue injuries induced by cisplatin, oxaliplatin, doxorubicin, bleomycin, and gefitinib. The underlying mechanisms involve reductions in oxidative stress and inflammation. H2 itself exhibits anticancer activity. Therefore, the combination of H2 and anticancer drugs has the potential to reduce the side effects of anticancer drugs and enhance their anticancer activities. This is an exciting prospect for future cancer treatments.
Development of a “Signal-On” Fluorescent Aptasensor for Highly Selective and Sensitive Detection of ZEN in Cereal Products Using Nitrogen-Doped Carbon Dots Based on the Inner Filter Effect
Authors: Sun Qi , Zhou Yuting , Ma Miaomiao , Zhang Fuyan , Li Shuang , Chen Zhuoer , Fang Yu , Le Tao , Xing Fuguo
Published: July 2024

This study aimed to develop a novel fluorescent aptasensor for the quantitative detection of zearalenone (ZEN), addressing the limitations of conventional detection techniques in terms of speed, sensitivity, and ease of use. Nitrogen-doped carbon dots (N-CDs) were synthesized via the hydrothermal method, resulting in spherical particles with a diameter of 3.25 nm. These N-CDs demonstrated high water solubility and emitted a bright blue light at 440 nm when excited at 355 nm. The fluorescence of N-CDs was quenched by dispersed gold nanoparticles (AuNPs) through the inner filter effect, while aggregated AuNPs induced by NaCl did not affect the fluorescence of N-CDs. The aptamer could protect AuNPs from NaCl-induced aggregation, but the presence of ZEN weakened this protective effect. Based on this principle, optimal conditions for ZEN detection included 57 mM NaCl, 12.5 nM aptamer concentration, incubation of AuNPs with NaCl for 15 min in Tris-EDTA(TE) buffer, and incubation of aptamer with ZEN and NaCl for 30 min. Under these optimized conditions, the “signal-on” fluorescent aptasensor for ZEN detection showed a linear range of 0.25 to 200 ng/mL with a low detection limit of 0.0875 ng/mL. Furthermore, the developed aptasensor exhibited excellent specificity and could rapidly detect ZEN in corn flour samples or corn oil, achieving satisfactory recovery rates ranging from 84.7% to 108.6%. Therefore, this study presents an economical, convenient, sensitive, and rapid method for accurately quantifying ZEN in cereal products.