bluuebunny/crossref_metadata_2025 huggingface dataset:
ARABICA COFFEE PRODUCTIVITY IMPROVEMENT STRATEGY WITH VALUE CHAIN ANALYSIS APPROACH (CASE STUDY: SAPAN VILLAGE, NORTH TORAJA
Authors: Asmal Sapta , Parenreng Syarifuddin Muhammad , Astutik Widi
Published: December 2022

Coffee is a farm commodity that has an important role in economic activities in Indonesia. The Indonesian coffee sector is dominated by small producers. North Toraja Regency, including in Sapan Village, is known as a producer of high quality coffee but low production. This study aims to examine the strategy of increasing coffee productivity in Sapan Village using value chain analysis. Data were collected through observation and interviews with cultivators in the value chain. This study shows that the productivity of coffee produced is still relatively low. The basic cause of low coffee productivity is that cultivation techniques are not good because information on good agriculture practices is still limited and there is a thought that the selling price of coffee is still low. To increase productivity, farmers need the role of the government. Farmers need counseling on coffee cultivation techniques that are in accordance with the application of GAP and price transparency from the government. If farmers have applied coffee cultivation techniques well, coffee productivity will increase so that farmers' income will also increase.
Spatial distribution of inter-nesting green turtles from the largest Eastern Atlantic rookery and overlap with a marine protected area
Authors: Raposo C , Mestre J , Rebelo R , Regalla A , Davies A , Barbosa C , Patrício AR
Published: December 2022

Understanding the spatial distribution of wildlife is fundamental to establish effective conservation measures. Tracking has been key to assess movement patterns and connectivity of sea turtles, yet some regions of great significance are largely understudied. We tracked 44 green turtles from the largest rookery in the Eastern Atlantic, on Poilão Island, Guinea-Bissau, during 2018 through 2020, to assess their inter-nesting movements, connectivity with nearby islands and fidelity to inter-nesting sites. Additionally, we investigated individual and environmental factors that may guide inter-nesting distribution and assessed the adequacy of a marine protected area to support this population during the breeding period. Green turtles had an overall home range of 124.45 km2, mostly occupying a restricted area around Poilão Island, with 52% of this home range falling within the no-take zone of the João Vieira-Poilão Marine National Park. Turtles exhibited strong fidelity to inter-nesting sites, likely as a strategy to save energy. Only 2 turtles performed significant excursions out of the park, and connectivity between Poilão and nearby islands within the park was limited. Larger turtles and turtles tagged later in the nesting season tended to have smaller core areas and home ranges; thus, experienced breeders may be moving less and potentially benefit from energy saving. This study highlights the importance of a marine protected area for the conservation of one of the largest green turtle breeding populations globally, and provides suggestions for further increasing its effectiveness.
Dynamics and aging of green turtle grazing plots at two Caribbean seagrass meadows
Authors: Constant N , Bolten AB , Johnson RA , Brooks AML , Bjorndal KA
Published: December 2022

Concerns over the sustainability of green turtle grazing have become a central topic in discussions of seagrass protection. Understanding grazing plot dynamics and aging is critical to evaluating the sustainability of grazing and understanding the role green turtles play in structuring seagrass foraging habitats. We investigated grazing plot dynamics and aging at 2 naturally grazed seagrass meadows in the Caribbean: one experiencing increasing grazing and one experiencing decreasing grazing. By integrating in-water characterization of grazing plots with aerial imagery of naturally grazed meadows, we show that green turtle grazing plots are dynamic, with establishment of new plots, expansion and merging of existing plots, and abandonment and regrowth of plots occurring within 3 and 13 mo periods. We also document that green turtles contribute to a component of habitat complexity by increasing edge habitat in seagrass meadows, and that they can maintain grazing plots for more than 9 yr. By July 2019, green turtles had been maintaining grazing plots for at least 6.65 yr where grazed area was decreasing and for at least 9.22 yr where grazed area was increasing. We offer new insight into the life cycle of grazing plots and show that green turtle grazing plot use is sustainable over longer periods than previously documented. Future studies investigating grazing plot dynamics and evaluating the sustainability of green turtle grazing over longer periods, across seasons, and in different regions, as well as evaluating cumulative effects of anthropogenic stressors, will be key to effective co-management of green turtles and globally declining seagrasses.
The Therapeutic and Prognostic Role of Clusterin in Diverse
Musculoskeletal Diseases: A Mini Review
Authors: Zhang K , Liu K , Yu D , Tang Y , Geng B , Xia Y , Xu P
Published: December 2022

This mini-review aims to introduce the association between Secretory clusterin/apolipoprotein J (sCLU) and diverse musculoskeletal diseases. A comprehensive review of the literature was performed to identify basic science and clinical studies, which implied the therapeutic and prognostic role of sCLU in diverse musculoskeletal diseases. sCLU is a multifunctional glycoprotein that is ubiquitously expressed in various tissues and is implicated in many pathophysiological processes. Dysregulated expression of sCLU had been reported to be assocaited with proliferative or apoptotic molecular processes and inflammatory responses, which participated in many pathophysiological processes such as degenerative musculoskeletal diseases including ischemic osteonecrosis, osteoarthritis (OA) and degenerative cervical myelopathy (spinal cord injury), neoplastic musculoskeletal diseases, inflammatory and autoimmune musculoskeletal diseases including Rheumatoid arthritis (RA), joint damage induced by Brucella abortus, Sjogren's syndrome, idiopathic inflammatory myopathies, muscle glucose metabolism, insulin sensitivity and traumatic musculoskeletal diseases. Recent findings of sCLU in these musculoskeletal diseases provides insights on the therapeutic and prognostic role of sCLU in these musculoskeletal diseases. sCLU may serve as a promising therapeutic target for ischemic osteonecrosis, OA and spinal cord injury as well as a potential prognostic biomarker for OA and RA. Moreover, sCLU could act as a prognostic biomarker for osteosarcoma (OS) and a promising therapeutic target for OS resistance. Although many studies support the potential therapeutic and prognostic role of sCLU in some inflammatory and autoimmune-mediated musculoskeletal diseases, more future researches are needed to explore the molecular pathogenic mechanism mediated by sCLU implied in these musculoskeletal diseases.
Cholesterol efflux and macrophage polarization in human adipose tissue
Authors: Králová A , Kubátová H , Kauerová S , Janoušek L , Froněk J , Králová Lesná I , Poledne R
Published: December 2022

The pro-inflammatory status of adipose tissue (AT) has been found to be related to reverse cholesterol transport (RCT) from peritoneal macrophages. However, this finding was made in experimental models using induced peritonitis and isolated peritoneal macrophages of animals. This experimental relationship is in agreement with RCT changes in man in two extreme situations, sepsis or cardiovascular complications.
Given the above, we sought to test RTC in relationship to macrophage polarization in the visceral AT (VAT) of living kidney donors (LKDs) and the effect of conditioned media obtained from their AT. The influence of ATCM on CE capacity was first assessed in an experiment where standard plasma was used as cholesterol acceptor from [14C] cholesterol labeled THP-1 cells. Conditioned media as a product of LKDs’ incubated AT showed no effect on CE. Likewise, we did not find any effect of individual plasma of LKDs on CE when individual plasma of LKDs were used as acceptors. On the other hand, we documented an effect of LKDs’ adipose cell size on CE. Our results indicate that the pro-inflammatory status of human AT is not likely induced by disrupted RCT but might be influenced by the metabolic status of LKDs’ adipose tissue.
A REVIEW STUDY IN MINING INDUSTRY
Authors: Elmardi Suleiman Khayal Dr. Osama Mohammed , Bashier Elagab Dr. Elhassan ,   Nile Valley University, Atbara, River Nile, Sudan
Published: December 2022

a comprehensive literature review of mining extraction and industry was made. The review discusses thoroughly mining industry from different viewpoints that includes general introduction, historical background of mining industry, mines development and life cycle, mining extraction techniques, machines used in mining processes, mineral processing, environmental effect on operators and the surrounding area, mining industry, safety precautions in mining industry, human rights abuses occurring within mining sites and communities in close proximity, mines records, metal reserves and recycling, and finally the mining industry in Sudan which includes history, production & impact, legal frame work, commodities, gold extraction and outlook.
ANALYZING THE PROJECT DELAY CAUSES IN THE SOUTH AFRICAN CONSTRUCTION INDUSTRY
Authors: Ekwuno Anthony Obododike , Nel Dr. H. ,   Faculty Of Engineering And Built Environment Of The University Of Johannesburg
Published: December 2022

Construction projects have experienced major delays in the past decades. Project delay is a big burden in setting up projects. Professionals have established that delay in a project can only be controlled if its symptom is detected and acknowledged on time. A project has been described as a one-time undertaking that is established for a purpose. A questionnaire was designed and used to obtain the stakeholders’ perceptions regarding the causes of project setbacks. The aim of this study is to detect and analyze the causes of project delays and their mitigation strategies. Fifty-four (54) causes of project delays were established through the literature review. Mitigation strategies against project delays were identified. The established mitigation strategies will help construction professionals to improve the successful delivery of projects. The study has proved that every project delay has a remedy. The three major stakeholders collectively contribute to the factors causing project delays. The study revealed that delays in one country may be different from another country. This study discovered that all the stakeholders are experienced and knowledgeable in terms of recognition of the factors creating project delays.
ABSORPTION COOLING SYSTEM UTILIZING DIESEL ENGINE EXHAUST HEAT
Authors: Mohammed Ahmed Yagoub Abdallah , Wageiallah Mohammed Dr. Osman , Elmardi Suleiman Khayal Dr. Osama Mohammed , Bashier Elagab Dr. Elhassan ,   Nile Valley University, Atbara, River Nile, Sudan
Published: December 2022

The global industrial development, the increasing demand for energy, the limited availability of resources for the future generations of fossil fuels, and the prevention of environmental damage caused by their burning have led to public concern. Increasing energy consumption by buildings has led the wider global attention to its social, environmental, and economic implications. In this study, the emission gases from diesel engines have been utilized to drive a single effect absorption cooling system. In this study, water and lithium bromide mixture is used as a working fluid in absorption cooling system to benefit from waste heat from diesel engine that it may reach 190°C. This system mostly require only waste heat as the energy source to function properly. It has several advantages such as lower required electricity compared with vapor compression system, and it uses safer refrigerant. Engineering Equation Solver EES was executed to analyze the performance of this system, and to study the effects of the temperature of the generator, the absorber, the condenser and the evaporator on the performance of the system and on the cooling capacity. The cycle simulation is based on the operating temperature ranges and fixed parameters which includes: Evaporating temperature within a range of 5-20 °C, generator temperature within a range of 90-120°C, condenser temperature ranges from 25 to 38°C, absorber temperature range from 25 to 34°C, effectiveness of heat exchanger range from 0.64 to 0.8, strong solution flow rate 0.05 to 1.5 kg/s. The Coefficient of Performance COP of the system, based on these inputs, reaches about 0.76 and the cooling capacity reaches to 14 kW. It is found that when the generator temperature is increased, the COP is decreased. This is because the increase in generator temperature lowers LiBr-water concentration. Also, the temperature increase of the generator increases the cooling capacity. The increase in the absorber temperature reduces the COP as well as the cooling capacity. This is due to a decrease in the concentration of the solution. The absorption rate could be raised by increasing the solution concentration. The higher the concentration, the greater the absorption rate. The COP and cooling capacity improves when the evaporator temperature increases. The increase in effectiveness of heat exchangers causes an increase of system COP.
Obesity and the Effects of Weight Reduction: A Spotlight on Women with Hormone Receptor-Positive Breast Cancer and Heart Disease
Authors: Rygiel Katarzyna
Published: December 2022

Obesity is a common overlapping risk factor for cancer and cardiovascular disease (CVD), and the long-term consequences of these chronic, interconnected diseases are severe. The importance of CVD in breast cancer (BC) patients and survivors has been well-established, and the potential impact of some BC treatments (such as cardiotoxic effects related to chemotherapy or targeted therapy with the use of doxorubicin or trastuzumab, and radiation therapy, especially in cases of left breast tumours) on the cardiovascular condition necessitates ongoing cardiological surveillance. In addition, the possible reduction of some underlying risk factors is critical to long-term protection of BC patients and survivors. The concept of obesity dynamically interacting with both BC and CVD is important because it is a modifiable risk factor, and the modern management of obesity deserves emphasis. In particular, for many BC patients and survivors, an effective weight reduction programme integrated with standard anticancer and cardiology therapies can improve patient outcomes. This review presents the complex relationships between overweight, obesity, CVD, and BC risk and highlights outcomes in post and premenopausal women, focussing on patients with hormone receptor-positive BC. The review provides evidence from epidemiologic, observational, and weight loss intervention trials which have examined the effects of weight reduction programmes on BC outcomes. Such studies have indicated that moderate weight loss, with regular physical exercises or stress reduction, can significantly improve BC outcomes. Future lifestyle intervention trials could support the incorporation of weight loss interventions as an integral element of comprehensive management for BC patients and survivors.
Prevalence of SARS-CoV-2 Cellular and Humoral Immunity Amongst Patients on Dialysis After the First Vaccination Campaign
Authors: Duarte Rui , Soares Rosa , Lu Ivan , Ferrer Francisco , Gama Paula , Gonçalves Hernâni , Lopes Karina , Sofia Flora , Cortes Carlos , Vila Lobos Ana
Published: December 2022

Background: Immunisation remains critical in prevention of serious COVID-19 infection. This study aimed to characterise the prevalence of humoral and cellular immunity in patients on maintenance dialysis in a nephrology centre 8 months after vaccination onset.

Methods: Real-world single-centre prevalence cross-sectional study enrolling patients on peritoneal and haemodialysis. Humoral response was measured as specific IgG (anti-spike protein receptor-binding domain IgG) and cellular response as T cell reactivity through interferon γ quantification as response to antigen.

Results: Of the 86 patients enrolled, 79.4% and 84.1% showed humoral and cellular immunity, respectively. Anti-spike protein receptor-binding domain IgG correlated with specific T cell reactivity (ρ=0.58; p<0.001). Vaccinated patients with associated high comorbidity burden and low serum albumin were at risk of absent immunity (p<0.05).

Conclusion: The prevalence of humoral and cellular immunity against severe acute respiratory syndrome coronavirus 2 in vaccinated Portuguese patients on maintenance dialysis is high. High comorbidity burden and low serum albumin are risk factors for absent immune response.
Recent Advances in the Treatment of Metastatic Soft Tissue Sarcoma
Authors: Davis Elizabeth J. , Keedy Vicki L.
Published: December 2022

Soft tissue sarcomas (STS) are a rare group of heterogeneous malignancies with >50 histologic subtypes that have varying biological behaviour and responsiveness to systemic therapy. The mainstay of therapy for metastatic STS in recent decades has been doxorubicin. To improve survival outcomes, numerous agents have been combined with doxorubicin; however, no combination has led to a survival benefit over doxorubicin alone until the recent use of olaratumab, a monoclonal antibody targeting platelet-derived growth factor-α. In addition to olaratumab, several other new drugs have surfaced as promising treatment options. Marine-derived chemotherapy agents, eribulin and trabectedin, are active in selecting STS subtypes. Both agents are effective in liposarcoma, while trabectedin also has activity in leiomyosarcoma. Further understanding of the importance of STS subtype-directed therapy, as well as the genomic complexities of STS, has led to development of several small molecule inhibitors for specific STS histologies. Agents targeting vascular endothelial growth factors, platelet-derived growth factors, and cyclin-dependent kinases 4 and 6 have all shown some efficacy in various STS subtypes. Similar to the selective activity of cytotoxic agents and small molecule inhibitors, immunotherapy, which has revolutionised management of numerous cancers, has also demonstrated activity in select STS subtypes. Collectively, these novel therapies highlight the importance of histology-directed approaches and of a greater understanding of the genomic landscape of STS. This review describes advances in chemotherapy, molecularly targeted, and immunotherapy agents for STS.
Prototipe Sistem Pendeteksi Banjir Berbasis IoT (Internet Of Things)
Authors: Mahmudin Mahmudin , Adiprawiro Sukisno Nugroho , Kurniawan Mochammad Fadhil Octo
Published: December 2022

Banjir merupakan salah satu bencana alam yang sering terjadi di Indonesia. Banyaknya kerugian yang disebabkan oleh banjir sudah tidak terhitung harganya. Hal ini juga dirasakan oleh warga dari Perumaha Cimone Mas Permai 2 Kota Tangerang. Setiap musim hujan bisa dipastikan mereka selalu terkena dampak banjir. Sebab karena itu, diperlukan sebuah usaha untuk mengecilkan kemungkinan kerugian yang diterima dengan dibuatnya prototipe sistem pendeteksi banjir sebagai pemantau ketinggian dan deras arus air. Sistem ini berbasis Internet of Things (IOT), yaitu suatu jaringan yang mengkoneksikan bermacam piranti fisik dengan protokolnya masing-masing. Sistem pendeteksi banjir ini menggunakan waterflow sensor untuk menghitung kecepatan aliran air, Water Level sensor sebagai pendeteksi ketinggian air, Arduino Uno sebagai pusat nilai dari berbagai sensor, Nodemcu ESP8266 sebagai pengirim nilai sensor kepada database di Firebase. Sistem akan beroperasi secara langsung ketika diberikan daya dan membaca tiap sensor yang akan dikirimkan kepada database. Warga akan mendapatkan informasi tentang ketinggian banjir melalui aplikasi Android yang terhubung dengan data internet. Dan admin bisa memantau laporan bantuan dari website admin.

 

Kata Kunci : Arduino Uno, Waterflow Sensor, Water Level Sensor, Android.
Kualitas Air Sumur Area TPA Jatiwaringin Tangerang Berdasarkan Parameter Kimia dan Mikrobiologi
Authors: ROSITA NITA
Published: December 2022

Air merupakan komponen lingkungan yang penting bagi makhluk hidup. Sumber air berasal dari air hujan dan air tanah. Tempat pembuangan akhir (TPA) sampah merupakan tempat dimana sampah mencapai tahap terakhir dalam pengelolaannya. Air sumur yang berdekatan dengan TPA dihadapkan dengan berbagai masalah. Permasalahan tersebut meliputi tingginya laju timbunan sampah, cairan lindi dan menurunnya kualitas lingkungan. Lindi merupakan hasil dekomposisi sampah yang menggunung terdiri dari bahan organik dan bahan anorganik. Berdasarkan latar belakang tersebut perlu dilakukan pengujian kimia dan mikrobiologi air sumur di area TPA Jatiwaringin Kabupaten Tangerang untuk mengetahui kelayakan air yang digunakan masyarakat. Metode yang digunakan adalah metode purposive sampling. Sampel air sumur di ambil dari Desa Buaran Jati, Desa Tanggul Rajeg dan Desa Tanjakan Mekar dengan jarak 250-1500 meter. Berdasarkan hasil pengujian kimia menunjukkan parameter pH (8,3%), nitrit (16,7%), dan klorida (8,3%) tidak memenuhi syarat sedangkan parameter sulfat 100% memenuhi syarat. Untuk parameter mikrobiologi terdapat satu (8,3%) sampel yang tidak  memenuhi syarat. Hasil penelitian menunjukkan ada 7 sampel (58,3%)  dari 12 sampel air sumur yang layak sesuai dengan Peraturan Menteri Kesehatan Nomor 416 Tahun 1990 tentang Daftar Persyaratan Kualitas Air Bersih secara kimia dan  mikrobiologi.
Analisis Potensi Bahaya Kecelakan Kerja Menggunakan Hazard and Operability Study di PT.XYZ
Authors: Sugama Yogi Winkler , Efelina Vita
Published: December 2022

PT.XYZ adalah salah.satu perusahaan manufaktur yang bergerak di bidang produk kertas dan juga tissue di Indonesia. Semenjak didirikannya perusahaan ini, banyak terdapat permasalahan pada kesehatan dan keselamatan kerja. Dalam melakukan identifikasi tentang Kesehatan dan Keselamatan Kerja (K3) pada institusi maupun proyek ada beberapa metode yang dapat digunakan, salah satunya adalah Hazard and Operability Studies (HAZOP). HAZOP adalah standar teknik analisis bahaya yang digunakan dalam persiapan penetapan keamanan dalam sistem baru atau modifikasi untuk suatu keberadaan potensi bahaya atau masalah. Berdasarkan penelitian yang sudah dilakukan dengan menggunakan metode Haz-ard and Operability Study didapatkan 9 sumber bahaya, dimana resiko ekstrim yang dapat menimbulkan kecelakaan kerja adalah bersumber dari sikap pekerja sendiri dan suhu yang terdapat pada ruangan tersebut. Penggunaan APD serta mem-berikan penjadwalan K3 tentang penggunaan APD sangat penting untuk menghindari resiko kecelakaan kerja serta mening-katkan kesehatann dan keselamatan saat bekerja cukup penting di area produksi PT.XYZ.
CEZA HUKUKUNUN AVRUPALILAŞMASI SÜRECİNDE EŞLEŞTİRME PROJELERİNİN ROLÜ
Authors: İNAN ORMAN Merve
Published: December 2022

Avrupa Birliği ceza ve ceza muhakemesi hukuku alanında yasama yetkisine kavuştuğu andan itibaren, ceza hukukunun Avrupalılaşması üzerine çeşitli bilimsel ve politik tartışmalar yürütülmektedir. Bu tartışmaların bir kısmı kuvvetler ayrılığı, Avrupa Birliği hukukunun genel ilkelerine saygı, temel hak ve özgürlüklerin korunması gibi geleneksel Avrupa Birliği hukuku tartışmalarının ceza hukuku özelinde nasıl gerçekleşeceği üzerineyken; diğer bir kısmı ceza hukukunun Avrupalılaşmasının kanunilik, şahsilik, suçluluk ve cezalandırılabilirlik gibi ceza hukukunun genel ilke ve doktrinleri üzerindeki etkilerinin analizine yönelmiştir. Bu çalışma ise, bu tartışmalar üzerinde durmak yerine Aday Üye Devletlerin ceza hukuku sistemlerinin Avrupalılaşmasına ve bu süreçte önemli rolleri bulunan ve Avrupa Birliği dış yardım programları kapsamında verilen hibelerle finanse edilen eşleştirme projelerine odaklanmıştır. Bu bağlamda, Türkiye’nin “adalet ve içişleri” alanında yürütmüş olduğu eşleştirme projelerinden “Ceza Adalet Sisteminde Mağdur Haklarının Güçlendirilmesi Eşleştirme Projesi” örnek olarak seçilmiştir. 2017-2019 yılları arasında, İspanya Krallığı’nın ortaklığında gerçekleştirilen bu projeyle, Türk ceza adalet sisteminde “etkin, sürdürülebilir ve ulaşılabilir bir mağdur destek sistemi” kurulmaya çalışılmıştır.
A Study on Factors Influencing Life Satisfaction of Elderly Women Living Alone: Focused on Parent-child Relationship, Subjective Cass Consciousness, Depression
Authors:   The Korean Society of Culture and Convergence, Han Sujeong
Published: December 2022

The purpose of this study is to identify factors affecting the life satisfaction of elderly women living alone. The subjects of this study were 625 elderly women living alone among 5,717 panelists in the 8th year panel survey of the KLoSA, and using SPSS and AMOS program, correlation between each variable and path model analysis were performed. As a result of the analysis, factors directly affecting the life satisfaction of elderly women living alone were identified as child relationship, subjective class consciousness, and depression variables. In addition, the parent-child relationship showed a significant influence on life satisfaction through subjective class consciousness and depression. Through the results of the study, it is proposed to continuously discuss and conduct research to improve the positive perception of subjective class consciousness, and to prevent and alleviate depression about the life satisfaction of elderly women living alone.
A Diachronic Study of Disability and Disease in Modern Korean Novels
Authors:   The Korean Society of Culture and Convergence, Na So Joung
Published: December 2022

When we look at the representation of disability and disease in our literature as a problem in the public domain arising from the contradiction of social structure rather than as a dimension of personal experience of personal misfortune, Is not limited to the problem of the physical personality of his personality but extends to the problem of the real condition of his body. In this case, the body of the character is a representation of the projected logic of social inequality, prejudice, and exclusion, and acts as a mechanism to expose its problems by not being easily incorporated / embraced in the problematic social reality. The way in which the societal and cultural contexts are closely linked by summoning the others present outside the community through the negativity of the pathological body reflects the distinct characteristics and historicity of Korean literature history. Characters with disabilities and diseases in Korean contemporary novels show one aspect of the value judgment of literature on the reality of the time, and therefore, diachronically examine how the concepts of disability and disease were constructed and discoursed by era from the perspective of literature history.
A Study on the Strategy of Brand Building in the Tongyeong Theater Arts Festival: Focused on the Strategy of Brand Construction
Authors:   The Korean Society of Culture and Convergence, Kim Sun Young , Song Hee-young
Published: December 2022

The need for brand building is growing at local arts festivals. Therefore, this study tried to contribute to the establishment of the brand strategy of the local art festival by analyzing the brand construction status of the Tongyeong Theater Arts Festival(TTAF) as a brand myth construction model. As a result of the study, in terms of the dominant ideology, the TTAF was exposed to negative perceptions such as their own league, low artistic level, and doubts about individuality and creativity, as commonly found in other regional festivals. In addition, the desires of consumers and masses were marked by independent consumption, demand for easy and comfortable arts, and enhancement of pride and self-esteem in local culture. To overcome the cultural contradiction, the TTAF is judged to have to focus more on regional specialization and artistic level improvement using the unique cultural resources of the region. Therefore, this study specifically suggests the improvement of the brand strategy of the TTAF through the supplementation and innovation of the PR marketing strategy.
A Study on the Educational Experience of Middle-Aged North Korean Refugee Women in South Korean Society: Focused on Graduates from Higher Education Institutions
Authors:   The Korean Society of Culture and Convergence, Kim Sunsook , Kim Seo Young
Published: December 2022

The purpose of this paper is to analyze the meaning of college education for middle-aged women who have fled North Korea and at the same time provide policy support to expand opportunities for higher education. Eight middle-aged North Korean defectors participated in the study. The data were constructed by conducting 1:1 in-depth interviews with the study participants. The data were analyzed by a descriptive phenomenological study presented by Colaizzi (1978). The results of the study are as follows. As a result of the study, 24 sub-components appeared. It was presented as nine components. Finally, it was rearranged into the categories of school, family, human capital, and social capital. Based on the research results, Based on the research results, we discussed the universal values and truths of university education, the relationship between universities and social capital, and their return to the diaspora and their dreams, and made suggestions to support North Korean refugee women's college admissions and studies.
ATENÇÃO VOLUNTÁRIA AO ESCREVER
Authors: Castro Rafael Fonseca de , Damiani Magda Floriana
Published: December 2022

Este artigo é fruto de uma pesquisa que investigou a evolução da escrita acadêmica em estudantes de um curso de Pedagogia a distância do sul do Brasil. Tratou-se de uma pesquisa qualitativa, do tipo intervenção pedagógica, pela qual, durante sete semestres, foram realizadas atividades orientadas e minucioso acompanhamento interventivo dos textos de três acadêmicas, adotando como base teórico-metodológica a Teoria Histórico-Cultural. Neste recorte, discute-se trechos das entrevistas com as acadêmicas relacionando a função psicológica superior atenção voluntária ao ato de escrever. Os indícios revelados sugerem relevância dessa relação no que se refere ao ensino e à aprendizagem da escrita. Nos depoimentos das acadêmicas, são perceptíveis, principalmente, focos de atenção voluntária direcionados ao ato de escrever com relação ao fato de que se escreve para outrem e, relativos à importância de dominar o conteúdo e sobre situações de prolixidade.
APROXIMAÇÕES ENTRE CINEMA E EDUCAÇÃO VISUAL:
Authors: Scareli Giovana , Alencar Samia Rafaella
Published: December 2022

Este estudo teve como recorte temático a adaptação para o cinema do romance Grande Sertão: Veredas, de Guimarães Rosa, escrito em 1956, dirigido pelos irmãos Geraldo e Renato Santos Pereira, e lançado, com o mesmo título, em 1965. O objetivo foi compreender aspectos da produção por meio da análise do filme e suas contribuições sobre as suas possibilidades educativas. Uma das questões que nos guiou: que tipo de saberes podemos construir a partir desse filme, o que nos educa a partir desse encontro? Para isso, destacamos Diadorim, como mito ligado à androginia sagrada e médium de reflexão. Por fim, discutimos sobre a política do olhar que nos auxiliou na compreensão d personagem e, por intermédio dela, para a compreensão dessa obra.
EDUCAÇÃO INCLUSIVA DE CRIANÇAS E JOVENS NA PANDEMIA DE COVID-19: REVISÃO INTEGRATIVA
Authors: Barreto-Colichi Rosana Maria , Molina Lima Silvana Andrea
Published: December 2022

Com o objetivo de identificar o conhecimento produzido sobre educação inclusiva e a pandemia de COVID-19, realizamos uma revisão integrativa da literatura, com 22 artigos, de 23 bases de dados como OneFile, PubMed, Web of Science, Sage Journals e Medline,  publicados de janeiro de 2020 a janeiro de 2021. A pandemia revelou desafios como falta de acesso à internet, uso de tecnologias, adaptação das atividades aos alunos com deficiência e suporte limitado para crianças e cuidadores. Impactos negativos do isolamento e da falta do ambiente escolar refletem em futuros problemas psicológicos e sociais. Adaptações nos sistemas educacionais e o desenvolvimento de respostas pedagógicas devem ser urgentes devido aos impactos na aprendizagem e na saúde das crianças e seus cuidadores.
APROPRIAÇÃO DO SISTEMA LINGUÍSTICO DA LÍNGUA PORTUGUESA POR ALUNOS SURDOS:
Authors: Ghizzo Neto Fellini Dinéia , Shimazaki Elsa Midori , Acencio Cristina Ferreira
Published: December 2022

Analisa-se, produções acadêmicas que tematizam leitura, escrita, revisão e reescrita de alunos surdos, a verificar o processo de apropriação do sistema linguístico do português escrito. Questionamos: Os alunos surdos conseguem se apropriar do sistema linguístico do português com as práticas atuais de ensino? Uma revisão sistemática da literatura fora realizada nas bases de dados da Scientific Electronic Library Online e Biblioteca Digital Brasileira de Teses e Dissertações. Com os descritores “leitura”, “escrita” e “surdos”, identificou-se 185 publicações, com amostra final, 13 estudos. Resultados: i) surdos com defasagens na língua materna e português escrito; ii) falta práticas de revisão e reescrita de textos; iii) ausência de propostas de leitura/escrita como trabalho pedagógico, que permita aos surdos, a construção de sentidos nos discursos escritos.
EMPREENDENDO RECURSOS DIDÁTICOS:
Authors: Machado Clarice Rosa , Becker Elsbeth Léia Spode , Ghisleni Taís Steffenello
Published: December 2022

Este artigo objetiva descrever o processo percorrido para a realização da gincana acadêmica online, com foco na liderança e no empreendedorismo da Enfermagem, alusiva à Campanha Nursing Now. O texto se dedica, com base no saber-fazer da Enfermagem e da comunicação, a problematizar o percurso dos desafios diários propostos e atendidos pelas dez equipes inscritas, de forma voluntária e gratuita. Esta atividade pedagógica online foi promovida pelo do Grupo de Estudos e Pesquisa em Empreendedorismo Social da Enfermagem/Saúde – GEPESES, da Universidade Franciscana e organizada por estudantes do Mestrado em Ensino de Humanidades e Linguagens- MEHL, sendo realizada durante os dias 22 a 30 de setembro de 2020. A metodologia adotada para a pesquisa é bibliográfica com relatos de experiência da gincana online. Os resultados, além, de promover sensibilidade, empatia, trabalho em equipe, criatividade, liderança e superação crescente, mostraram que a metodologia aplicada é um excelente recurso para o despertar da autonomia e do protagonismo empreendedor de estudantes e profissionais da Enfermagem e fomentaram a interdisciplinaridade e a interação com a comunidade.
ANÁLISE DO DISCURSO DAS ORIENTAÇÕES CURRICULARES PARA O ENSINO MÉDIO – OCEM: CURRÍCULO, INTERPELAÇÃO IDEOLÓGICA E ENSINO DE LITERATURA
Authors: Diniz Ana Lúcia Pascoal , Vieira Demóstenes Dantas , Brito Luan Talles de Araújo
Published: December 2022

Com base na Análise do Discurso de linha pecheutiana, este trabalho propõe uma reflexão sobre as Orientações Curriculares para o Ensino Médio – OCEM, mais especificamente, sobre a abordagem dada ao ensino de literatura. Parte de uma aproximação teórico-epistemológica entre as teorias do currículo e a concepção de Aparelho Ideológico do Estado Escolar – AIEE proposto por Althusser (1990). Os resultados apontam para uma formação discursiva em que se materializa a distinção social entre literatura erudita e literatura popular. As materialidades discursivas analisadas revelam traços de um discurso colonizador em que as preferências culturais do aluno, a literatura de massa e as  manifestações populares são, até certo ponto, estigmatizadas sob a égide do “rigor” dado à literatura clássica, modelo que determina o que deve ou não ser trabalhado em sala de aula.  A análise realizada aponta para a necessidade de problematização dos documentos oficiais acerca do ensino de literatura que, sob a interpelação do Aparelho Ideológico do Estado Escolar – AIEE, (re)produz o discurso colonizador que separa o gosto douto do gosto popular, a literatura clássica da literatura marginal, supostamente, inferior.
Work strategies developed by creative workers in Mexico City: Enhanced precarity and adjustments during pandemic social distancing periods
Authors: Molina Ahtziri , Garduño Bianca
Published: December 2022

The 2020 COVID pandemic has been a major challenge for Mexican creative workers, whose working conditions were already precarious since before the world crisis. Through qualitative analysis of conversational interviews, we identified a series of adjustments and professional decisions made in the context of social distancing. Our findings show that precarious working conditions in which they already worked were aggravated during the pandemic social distancing periods to even threaten their possibilities to keep their place in the creative sector. We identified five different earning strategies with which they navigated uncertainty during the pandemic. Finally, we discussed the inequalities they face while trying to earn an income through multiple activities and, at the same time, updating their knowledge and capabilities to adjust their creative work to the new realities.
Bibliometric analysis of spatio-temporal model using a general product-sum based on a hydrological distance
Authors: Bachrudin Achmad , Ruchjana Budi Nurani , Abdullah Atje Setiawan , Budiarto Rahmat
Published: December 2022

In the last two decades, the number of model developments in the field of Geostatistics increased rapidly, especially in the Spatio-temporal models. Almost of these models are based on Euclidean distance, only a few which based on non-Euclidean distance. The purpose of this study is to analyze and visualize the types of literatures on stationary Spatio-temporal models that utilize General Product-sum and Hydrological distance through bibliometric analysis methods, by considering a set of bibliometric metrics, including productive and impact measures, methods analysis, and co-authorships analysis. Scientific research works related to Spatio-temporal models using the product-sum field that consider hydrological aspects, published between 2002 and 2022 are reviewed. Some of the most relevant research works in this field and some of the newest trends are collected during September 2022 from Google Scholar, Scopus and Dimensions databases. The literature search method is carried out in two steps. Firstly, literature sources were obtained from Google Scholar, Scopus and Dimensions. Secondly, meta-analysis is performed using Harzing's Publish or Perish and VOSviewer software program. Total of 488 articles related to Spatio-temporal product-sum, and 8 articles related to Spatio-temporal product-sum based on hydrologic distance are selected. The analysis result shows that the proposed topic “Spatio-temporal model using product-sum based on hydrologic distance” has a different significant attribute from the existing research works, i.e., the hydrologic distance. Therefore, the proposed topic can be considered has a novelty.
Hourglass-shaped grafts are superior to conventional grafts for restoring knee stability and graft force at knee flexion angle of 30° following anterior cruciate ligament reconstruction: A finite element analysis
Authors: Wang Huizhi , Fang Chaohua , Tao Mingzhu , Shi Qinyi , He Kaixin , Cheng Cheng-Kung
Published: December 2022

Background: Anterior cruciate ligament reconstruction (ACLR) using a generally columnar graft is considered the gold standard for treating anterior cruciate ligament ruptures, but such grafts cannot replicate the geometry and mechanical properties of the native anterior cruciate ligament.

Purpose: To evaluate the effectiveness of an innovative hourglass-shaped graft versus a traditional columnar graft for restoring joint stability and graft force, while avoiding notch impingement following anterior cruciate ligament reconstruction.

Methods: Finite element models of a human knee were developed to simulate ① An intact state, ② anterior cruciate ligament reconstruction using columnar grafts with different diameters (7.5–12 mm in 0.5 mm increments), ③ anterior cruciate ligament reconstruction using columnar grafts with different Young’s moduli (129.4, 168.0 and 362.2 MPa) and ④ anterior cruciate ligament reconstruction using hourglass-shaped grafts with different Young’s moduli. The knee model was flexed to 30° and loaded with an anterior tibial load of 103 N, internal tibial moment of 7.5 Nm, and valgus tibial moment of 6.9 Nm. The risk of notch impingement, knee stability and graft forces were compared among the different groups.

Results: This study found that columnar grafts could not simultaneously restore knee stability in different degree of freedoms (DOFs) and graft force to a level similar to that of the intact knee. The anterior tibial translation and graft force were restored to a near-normal condition when the internal tibial rotation was over-restrained and valgus tibial rotation was lax. A graft diameter of at least 10 mm was needed to restore knee stability and graft force to physiological levels, but such large grafts were found to be at high risk of notch impingement. In contrast, the hourglass-shaped graft was able to simultaneously restore both knee stability and graft force at knee flexion of 30° while also having a much lower risk of impingement.

Conclusion: Under knee flexion angle of 30°, an hourglass-shaped graft was better able to restore joint stability and graft force to a near-physiological level than columnar grafts, while also reducing the risk of notch impingement.
Molecular, morphological and functional properties of tunnelling nanotubes between normal and cancer urothelial cells: New insights from the in vitro model mimicking the situation after surgical removal of the urothelial tumor
Authors: Resnik Nataša , Baraga Diana , Glažar Polona , Jokhadar Zemljič Špela , Derganc Jure , Sepčić Kristina , Veranič Peter , Kreft Mateja Erdani
Published: December 2022

Tunnelling nanotubes (TNTs) are membranous connections that represent a unique type of intercellular communication in different cell types. They are associated with cell physiology and cancer pathology. The possible existence of tunnelling nanotubes communication between urothelial cancer and normal cells has not yet been elucidated. Therefore, we analyzed TNTs formed by T24 cells (human invasive cancer urothelial cells) and normal porcine urothelial (NPU) cells, which serve as surrogate models for healthy human urothelial cells. Monocultures and cocultures of NPU and T24 cells were established and analyzed using live-cell imaging, optical tweezers, fluorescence microscopy, and scanning electron microscopy. TNTs of NPU cells differed significantly from tunnelling nanotubes of T24 cells in number, length, diameter, lipid composition, and elastic properties. Membrane domains enriched in cholesterol/sphingomyelin were present in tunnelling nanotubes of T24 cells but not in NPU cells. The tunnelling nanotubes in T24 cells were also easier to bend than the tunnelling nanotubes in NPU cells. The tunnelling nanotubes of both cell types were predominantly tricytoskeletal, and contained actin filaments, intermediate filaments, and microtubules, as well as the motor proteins myosin Va, dynein, and kinesin 5B. Mitochondria were transported within tunnelling nanotubes in living cells, and were colocalized with microtubules and the microtubule-associated protein dynamin 2. In cocultures, heterocellular tunnelling nanotubes were formed between NPU cells and T24 cells and vice versa. The presence of connexin 43 at the end of urothelial tunnelling nanotubes suggests a junctional connection and the involvement of tunnelling nanotube in signal transduction. In this study, we established a novel urothelial cancer-normal coculture model and showed cells in the minority tend to form tunnelling nanotubes with cells in the majority. The condition with cancer cells in the minority is an attractive model to mimic the situation after surgical resection with remaining cancer cells and may help to understand cancer progression and recurrence. Our results shed light on the biological activity of tunnelling nanotubes and have the potential to advance the search for anticancer drugs that target tunnelling nanotubes.
Development and validation of a nomogram for predicting significant coronary artery stenosis in suspected non-ST-segment elevation acute coronary artery syndrome with low-to-intermediate risk stratification
Authors: Chen Meixiang , Li Pengfei , Huang Yuekang , Li Shuang , Ruan Zheng , Qin Changyu , Huang Jianyu , Wang Ruixin , Lin Zhongqiu , Liu Peng , Xu Lin
Published: December 2022

Background

Patients with non-ST-segment coronary artery syndrome (NSTE-ACS) have significant heterogeneity in their coronary arteries. A better assessment of significant coronary artery stenosis (SCAS) in low-to-intermediate risk NSTE-ACS patients would help identify who might benefit from invasive coronary angiography (ICA). Our study aimed to develop a multivariable-based model for pretesting SCAS in suspected NSTE-ACS with low-to-intermediate risk.

Methods

This prediction nomogram was constructed retrospectively in 469 suspected NSTE-ACS patients with low-to-intermediate risk. Patients were divided into a development group (n = 331, patients admitted to hospital before 1 May 2021) and a temporal validation group (n = 138, patients admitted to hospital since 1 May 2021). The outcome was existing SCAS, including left main artery stenosis ≥50% or any subepicardial coronary artery stenosis ≥70%, all confirmed by invasive coronary angiography. Pretest predictors were selected using Least Absolute Shrinkage and Selection Operator (LASSO) and stepwise logistic regression.

Results

Derivation analyses from the development group (n = 331, admitted before 1 May 2021) generated the 7 strongest predictors out of 25 candidate variables comprising smoker, diabetes, heart rate, cardiac troponin T, N-terminal pro-B-type natriuretic peptide, high-density lipoprotein cholesterol, and left atrial diameter. This nomogram model showed excellent discrimination ability with an area under the receiver operating characteristic curve (AUC) of 0.83 in the development set and 0.79 in the validation dataset. Good calibration was generally displayed, although it slightly overestimated patients’ SCAS risk in the validation group. Decision curve analysis demonstrated the clinical benefit of this model, indicating its value in clinical practice. Furthermore, an optimal cut-off of prediction probability was assigned as 0.61 according to the Youden index.

Conclusion

A prediction nomogram consisting of seven readily available clinical parameters was established to pretest the probability of SCAS in suspected NSTE-ACS patients with low-to-intermediate risk, which may serve as a cost-effective risk stratification tool and thus assist in initial decision making.