bluuebunny/crossref_metadata_2025 huggingface dataset:
Nursing actions at the CIPESC® project about educative practice for hypertensive clients: an exploratory study
Authors: Bezerra Sara T. F. , Coelho Manuela M. F. , Silva Lucia de Fatima da , Freitas Maria Célia de , Guedes Maria V. C.
Published: October 2022

High blood pressure is a chronic disease, which treatment alters the style of life of the carrier. This study tries to identify in the CIPESC Project the nursing procedures in the health education of hypertension patients and confirm them as professional practices of the Programa Saúde da Família (PSF). It is an exploratory-descriptive study that tries to validate the results from the CIPESC-Brasil Project, developed with twelve nurses in Fortaleza, CE. The investigation was approved by the Comitê de Ética em Pesquisa of the Universidade Estadual do Ceará and the participation was voluntary including signature of the Termo de Consentimento Livre e Esclarecido. The data was collected by means of an elaborate questionnaire about the CIPESC results of 88 learning practices for hypertensive patients. In order to follow the nurses’ carrying out of the program, nursing visits were also observed. It was found that 76 (86%) practices were widely used, 10 (11%) were used sometimes, and 2 (2%) were used seldom. In other words, all 88 practices studied in the CIPESC Project can be used in the Educação em Saúde of hypertensive patients. These practices are divided in the following: attending, 31; informing, 30; observing, 17; and managing, 10. It was concluded that the identified practices of the CIPESC Project are being executed by the nurses of the Programa Saúde da Família with hypertensive patients.
The role of real world data and real world evidence in health technology assessment
Authors: Novoderezhkina E. A. , Zyryanov S. К.
Published: October 2022

Real world data (RWD) and real world evidence (RWE) is one of the most rapidly developing areas in the modern health care systems, which is caused by the development of technologies for both collecting and analyzing data, the emergence of new data sources and the formation of needs both by regulatory bodies, health technology assessment (HTA) agencies, and by the clinical and scientific communities. However, at the moment, there is no universal approach to RWD/E generation and application in the context of HTA. Over the past few years, the rate of including RWD/E in the HTA dossier has noticeably increased, but the nature of the existing guidelines and recommendations is rather fragmentary, which might create obstacles in the way of RWD/E study development and submission. The publication is aimed to describe and summarize the main and most rapidly developing spheres of RWD/E applications and analyze the possibilities of using RWD/E in various HTA areas in the world and in the Russian Federation considering the main trends in the further HTA development.
Economic aspects of using new chemotherapy regimens for multidrug and extensively drugresistant tuberculosis
Authors: Kukurika А. V.
Published: October 2022

Objective: to systematize data on cost-effectiveness evaluation of new multidrug and extensively drug-resistant tuberculosis (MDR/XDR-TB) chemotherapy regimens.

Material and methods. An analysis of 19 publications devoted to the economic evaluation of the treatment of active MDR/XDR-TB was carried out. The literature search was performed in the electronic databases PubMed/MEDLINE, Google Scholar, eLibrary for the period from January 2015 to February 2022 inclusively.

Results. Economic efficiency was studied in high-, middleand low-income countries. All publications contained calculation of treatment costs, and a third of the studies also estimated additional costs. Bedaquiline, delamanid, and pretomanid regimens were included in treatment alone or compared with a background regimen. The most commonly used economic model was the Markov one. To compare primary outcomes, most studies assessed disabilityand quality-adjusted life years. The overall cost of MDR/XDR-TB treatment varied by country income level. In all cases, bedaquiline-based regimens represented a cost-effective alternative to previous treatment, showed high efficacy in MDR/XDR-TB therapy, and were more cost-effective than delamanid regimens.

Conclusion. Cost-effective interventions for active MDR/XDR-TB therapy should include the introduction of new chemotherapy regimens, reduced hospital stays and decentralized treatment, which is especially relevant in countries with high tuberculosis burden.
Economic burden of the novel coronavirus infection: a systematic review
Authors: Timiryanova V. M. , Lakman I. A. , Zagidullin N. Sh. , Gareeva D. F.
Published: October 2022

Background. The sudden emergence and rapid spread of the novel coronavirus infection (COVID-19) caused tremendous burden on the health care system including the economic one. In this regard, many questions concerning the prioritization of funding for various restrictive and preventive procedures have arisen; also the introduction of various intervention methods for monitoring and timely treatment of post-COVID consequences became an urgent problem. These challenges actualized the development of pharmacoeconomic methods that improve the quality of decisions making in such extreme conditions.

Objective: to systematize available studies on the assessment of the global economic burden of the novel coronavirus infection.

Material and methods. A feature of the proposed review design was the highlighting of the observed shortcomings and areas in which scientists make additions to the assessment methods taking into account the chronology of the pandemic determining changes in the information field. Therefore, an analysis was made of 80 studies published in 2020–2022 and dedicated to the assessment and forecast of the global economic burden of COVID-19. The main inclusion criteria for the studies was the estimation of COVID-19 global burden. The search was carried out in PubMed/MEDLINE, Web of Science, Scopus, and eLibrary databases. Using a predefined data collection form, two reviewers independently extracted information characterizing the studies.

Results. An analysis of the publications showed a fairly wide variety of studies in the field of the COVID-19 burden, including those determined by the difference in observation objects, analysis methods, factors taken into account, etc. Scientists actively use international (73.8%) and national (90%) databases, and surveys (57.5%). Predominantly, the estimates involve the calculation of quality-adjusted life years lost (QALY) (66.3%), 37.6% of the studies are based on the results of constructing scenario models, 28.8% consume algorithms of epidemiological SIR (susceptible, infected, or recovered) models, and 66.3% provide for cost assessment. As part of the estimated economic burden, the loss of productivity (26.3% of publications), the introduction of vaccination (32.5%), comorbidity (25%), post-COVID complications (17.5%) are considered.

Conclusion. A significant interest of the world scientific community in assessing the COVID-19 global burden is observed, determined by the search for the most effective study methods. Further investigations in this area should focus on detailing within the estimated economic burden of losses associated with post-COVID-19 complications, including their various combinations, as well as on the analysis of the correlation and mutual compensation of effects from various types of treatment, with a deeper study of indirect losses. The results of this work will be also useful in conducting similar studies, including for determining their design and applying modern mathematical modeling tools.
Double threat: Ovarian cancer and thrombotic complications
Authors: Mansurova Alfiya S , Krasilnikov Sergey E , Voitcitckii Vladimir E
Published: October 2022

Currently, patients with cancer are undoubtedly more likely to develop thrombosis and thromboembolism. In some cases, symptoms of thrombotic complications could be the first signs of a malignant tumor. Thus, the treatment of such patients should follow two directions: treatment of cancer and maintenance therapy aimed at coagulopathy correction. Anticoagulant and antiplatelet therapies are high priorities in the treatment of these conditions; however, their adverse effects should not be forgottenhigh risk of bleeding. There is a very fine line between the risks of thromboembolic complications and bleeding; both conditions can threaten the patients life. Thus, a multidisciplinary approach, timing, and balanced treatment can save patients lives.
A Magnitude Estimation Approach and Application to the Yunnan Earthquake Early Warning Network
Authors: Zhang Guo-quan , Li Dan-ning , Gao Yang , Yang Jing-qiong
Published: October 2022

Estimating the magnitude based on P waves is important to issue early messages to the general public for earthquake early warning (EEW) purposes. First, we reviewed part of the magnitude estimation results of the current EEW system deployed in Yunnan and found that the magnitude of the mainshock of the Yangbi earthquake sequence (Ms 6.4, as formally determined by the Yunnan Seismic Network) is severe underestimated by 0.9, whereas a number of small earthquakes are overestimated. Then, we determined the reason for this phenomenon and improved the magnitude estimation precision in Yunnan by introducing the fixed effect regression technique, adopting a flexible time window and deriving the magnitude estimation equation strictly. Finally, we examined the deficiencies of this magnitude estimation approach and demonstrated that it is possible to provide instant and reliable parameters of an earthquake through numerous inexpensive accelerometers on the ground.
The review of the bronchial asthma morbidity in the population of the Russian Federation
Authors: Bystritskaya E. V. , Bilichenko T. N.
Published: October 2022

According to the World Health Organization (WHO), bronchial asthma (BA) is a major non-communicable disease which affects both adults and children and thereby impacts the economy.

The aim. To analyze the bronchial asthma morbidity and follow-up care in Russia in 2019 as compared with 2014.

Methods. The official statistical data of the Ministry of Health of Russia and the Federal State Statistics Service (Rosstat) on BA was used. BA was defined as class X J45 – J46 (asthma, asthmatic status) according to the International Classification of Diseases and Health-Related Problems, the 10th revision of 1 989 (ICD-10).

Results. The BA morbidity was 961.6 in 2014 and 1085.0 (+11.4%; p < 0,001) per 100 thousand of the total population in 2019 (1,592,596 people). BA accounted for 2.7% of all respiratory diseases (RD) morbidity. The BA morbidity in 2014 and 2019 were higher than average in 4 federal districts (FD) with the maximum rate in the Siberian FD (1,185.5 and 1,507.1 per 100 thousand of the total population, respectively). In 2019, the BA morbidity decreased among children aged 0 – 14 years, did not change among children aged 15 – 17 years and increased among the adults. In 2019, the highest rates among children aged 15 – 17 years were registered in the North-Western FD (2,943.7 per 100 thousand in the corresponding age group). 87.1% of BA patients received follow-up care. In 2019, 32.3% of all people with respiratory diseases (944.3 per 100 thousand of the total population) were under follow-up care. The highest number of BA patients under follow-up care was recorded in the Siberian FD (1,328.3 per 100 thousand of the total population), the lowest number – in the North Caucasian FD (288.3).

Conclusion. There was an increase of BA morbidity from 2014 to 2019 with the highest numbers reported in the total population of Siberian FD and the lowest – in adolescents aged 15 – 17 years in North-Western FD. The quality of medical care correlated with high coverage with follow-up care.
Experience of using benralizumab in the treatment of patients with severe asthma in the clinical practice of pulmonologists in Saint-Petersburg
Authors: Sereda V. P. , Svirido D. A. , Komarov M. V. , Mironova Zhanna A , Nyoma M. A.
Published: October 2022

The accumulation of clinical experience in the use of biologic therapy in patients with severe bronchial asthma (SBA) in real-world clinical practice with the possible identification of additional, previously undescribed clinical outcomes is of practical interest.

The aim. To present the results of an observational study of using benralizumab in SBA in real clinical practice of pulmonologists in Saint-Petersburg.

Methods. We present the results of more than 1 year of follow-up of 18 patients with eosinophilic SBA (12 women, 6 men, age from 28 to 74, average age 55.0 ± 11.9 years). The patients received benralizumab in addition to standard treatment. Clinical, laboratory, and functional examination of the patients were performed, the frequency of exacerbations and additional clinical effects were assessed. Results. It has been shown that the inclusion of benralizumab in complex therapy resulted in a significant improvement in disease control, improved bronchial conduction, a significant decrease in blood eosinophilia, and a reduction in the number of exacerbations. A clinical example is given that indicates a stabilizing effect of this therapy on the course of recurrent nasal polyposis with an initially aggressive course (intracranial polyp growth).

Conclusion. The possibility of significant improvement in the control of SBA with the use of biological therapy has been confirmed in real clinical practice. At the same time, data have been obtained that will allow expanding the indications for the use of benralizumab in the future.
Blood plasma cathepsin S in severe bronchial asthma
Authors: Kraposhina A. Yu. , Sobko E. A. , Demko I. V. , Katser A. B. , Kazmerchuk O. V. , Abramov Yu. I. , Eydemiller N. S.
Published: October 2022

The aim. To determine the level of cathepsin S and to identify its possible relationships with clinical, functional and laboratory indicators in patients with severe bronchial asthma.

Methods. 114 patients with severe bronchial asthma were examined. 96 women (84.2%) and 18 (15.8%) men were divided into 2 groups: allergic and non-allergic severe bronchial asthma. The external respiration function was assessed with whole-body plethysmography (“Erich Jaeger”, Germany). The plasma concentration of cytokines IL-4, IL-5, IL-13, periostin, cathepsin S, TGF-β was estimated with ELISA (“eBioscience”, USA).

Results. Fixed obstruction is reported in 48% and 50% of cases of allergic and non-allergic severe asthma, respectively. Peripheral blood eosinophilia occurs in 41.5% of cases with allergic and in 25% of cases with non-allergic asthma. IL-5, IL-13, and cathepsin S levels were increased in both groups. An increase in IL-4 and TGF-β levels was revealed in non-allergic asthma. Periostin levels were increased in patients with allergic asthma as compared with the control and the second group. Positive correlation between cathepsin S and concentration of IL-4, IL-5 was established in both groups. We identified weak positive correlation between cathepsin S levels and clinical symptoms of the disease, such as frequency of SABA use and asphyxiation attacks, only in the allergic asthma group. A positive correlation between cathepsin S and TGF-β was established in both groups.

Conclusion. A positive correlation between serum cathepsin S and TGF-β was established in both allergic and non-allergic severe bronchial asthma. The found moderate relationship may indirectly indicate the involvement of cathepsin S in airway remodeling processes regardless of the disease type.
An Efficient Approach for Line-Following Automated Guided Vehicles Based on Fuzzy Inference Mechanism
Authors: Bach Sy-Hung , Yi Soo-Yeong
Published: October 2022

Recently, there has been increasing attention paid to AGV (Automated Guided Vehicle) in factories and warehouses to enhance the level of automation. In order to improve productivity, it is necessary to increase the efficiency of the AGV, including working speed and accuracy. This study presents a fuzzy-PID controller for improving the efficiency of a line-following AGV. A line-following AGV suffers from tracking errors, especially on curved paths, which causes a delay in the lap time. The fuzzy-PID controller in this study mimics the principle of human vehicle control as the situation-aware speed adjustment on curved paths. Consequently, it is possible to reduce the tracking error of AGV and improve its speed. Experimental results show that the Fuzzy-PID controller outperforms the PID controller in both accuracy and speed, especially the lap time of a line-following AGV is enhanced up to 28.6% with the proposed fuzzy-PID controller compared to that with the PID controller only.
PENSANDO O CURRÍCULO DA GEOGRAFIA ESCOLAR E A FORMAÇÃO DE PROFESSORES NOS PAÍSES DO CONE SUL
Authors: Batista Natália Lampert , Lenz Ana Carla , Rizzatti Maurício , Becker Elsbeth Léia Spode , De David Cesar
Published: October 2022

No presente artigo buscamos discutir elementos que caracterizem e que remontem uma reflexão sobre o currículo e/ou estratégias curriculares para a Geografia em países do Cone Sul, bem como destacamos a relação do currículo com a formação de professores. O texto se caracteriza por ser uma revisão teórica associada a percepções e debates oriundos das trajetórias acadêmicas dos autores do presente artigo. Evidenciamos que algumas das estruturas curriculares de Geografia nos cinco países do Cone Sul (Argentina, Brasil, Chile, Paraguai e Uruguai), por vezes, são bem distintas, entretanto, em outros momentos, aproximam-se bastante. Ressaltamos, também, que uma formação de professores que permita conhecer essas distintas realidades pode ser bastante promissora e auxiliar na resolução de demandas docentes nas escolas, assim, discutimos a formação de professores como um ponto a ser integrado entre os países do Cone Sul. Concluímos que pensar as questões curriculares é central a contemporaneidade, especialmente, no atual contexto, marcado por mudanças políticas, sociais e econômicas, a fim de que não se perca a dimensão crítica da Geografia Escolar nos países do Cone sul. Além disso, ressaltamos que a importância do debate acerca da formação de professores para as questões que permeiam o currículo escolar, ou seja, não é possível pensar currículo aquém da formação docente.
Taste dyfunction in obese type 2 diabetic individuals
Authors: Hasan Afshan Zainab , Preethi B L  , Kalra Pramila , Kumar M Arun
Published: October 2022

Obesity is a well-known risk factor for many diseases. It is also known to enhance complications of many diseases eg. Type 2 Diabetes mellitus (T2DM). This study was done to assess the gustatory functions in obese T2DM individuals.

This study was done to assess the gustatory functions in obese T2DM subjects and compare the same with lean T2DM individuals.

A comparative study with a sample size of 40 was conducted. Patients aged 25 to 50 years with T2DM < 5 years duration and HBA1C ≤ 7 were divided into 2 groups, Group I- with normal weight (BMI of 18.5 to <25) and Group II with grade 1 obesity (BMI of 30 to < 35). Triple Drop Test was done to evaluate gustatory functions. Scoring from “5” to “1” was done on the identification of different concentrations of tastants.

Taste scores for sweet, salty, sour, and bitter tastants were lesser in obese diabetics as compared to the lean T2DM subjects. This was statistically significant (p < 0.05) Conclusion: Taste impairment is observed in obese diabetic subjects. This could be an indication of early central diabetic neuropathy. Hypogeusia may cause an increased preference for sweet-tasting or salty foods thus imposing greater health risks, increasing obesity, and negatively affecting the quality of life.
Variations in renal arteries and pelvicalyceal system: A case report
Authors: Hottigoudar Suma Yekapppa , Akhil Jakkula , Stephen Priyanka Clementina , Sontakke Yogesh Ashok
Published: October 2022

To describe a complex case of anomalous kidneys involving right early division of renal artery, left accessory renal artery, bilateral upper polar arteries and bilateral extrarenal calyces. This is a very rare case documented having these four anomalies together.

The variations were observed during routine anatomical dissection in a male cadaver at department of anatomy, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Pondicherry, India

During dissection, multiple anatomical variations involving the structures at the hilum of right kidney were found. Right kidney showed early division of renal artery (RRA) 1.4 cm close to aorta. Left kidney showed accessory renal artery (LARA) 5 mm above origin of main renal artery (LRA), running obliquely entering the hilum. Two polar arteries were seen entering upper pole on right kidney as well as left kidney (RUPA1, RUPA2, LUPA1, LUPA2). Extrarenal calyces were observed to be present in both the kidneys, two on the right and three on the left.

The variations observed are of importance as multiple anomalies are present in a single cadaver. They are of significance during surgical procedures like renal transplantation, aortic surgeries and in radiological interpretation.
Educação no Contexto da Pandemia: Percepções Críticas da Coordenação Pedagógica
Authors: Santos Juvenicio Jesus dos , Santo Eniel do Espirito , Souza Naiara Santana
Published: October 2022

Este artigo é resultado de percepções críticas da coordenação pedagógica da Rede Pública de Educação do Estado da Bahia e objetiva analisar as contribuições da Coordenação Pedagógica no processo de Ensino Remoto Emergencial, durante o período de distanciamento físico, sem atividades escolares presenciais, em virtude da pandemia de Covid-19. Configura-se como um relato de experiência implicada de 2 (dois) Coordenadores Pedagógicos, atuantes em 2 (dois) colégios públicos, no interior da Bahia, no período entre 2020 e 2022. O estudo aponta que a Coordenação Pedagógica atuou de forma incisiva para gerir alguns entraves que emergiram na gestão da aprendizagem dos estudantes nesse período, tais como alto índice de evasão escolar, déficit na construção das aprendizagens e precarização do trabalho pedagógico. Esse processo também favoreceu o desenvolvimento de novas competências digitais para professores, coordenadores e direção escolar, contribuindo para promover práticas híbridas de ensino no pós-pandemia.

Palavras-chave:Coordenação pedagógica. Ensino remoto emergencial. Cibercultura.
İnşaat Sürecinin İş Çizelgelemesi, Yönetimi ve Optimizasyonu
Authors: BETTEMİR Onder , BULAK Ömer
Published: October 2022

Bu çalışmada bina inşaatı ile ilgili iş paketlerinin metrajı, adam.saat ve malzeme gereksinimi hesaplamaları, aktivite süresi ve ekip sayılarının belirlenmesi ile iş çizelgelemesinin oluşturulması işlem adımları yapının geometrisi, imalatlar ve temin edilebilen kaynaklar ile ilişkilendirilip formülleştirilmiştir. Hesaplanan metraj değerleri Türkiye Cumhuriyeti Çevre, Şehircilik ve İklim Değişikliği Bakanlığı’nın hazırladığı birim fiyat analizlerinde kullanılan poz listelerindeki malzeme, işçilik ve makine kullanımları ile ilişkilendirilerek tüm iş kalemleri için gereken malzeme, işçilik ve iş makinesi miktarları belirlenmiştir. Ayrıca iş kalemleri arasındaki fiziksel ve mantıksal ilişkiler göz önüne alınarak doğrusal iş programı ile inşaatın tamamlanma süresi tahmin edilmiştir. İnşaatta çalışan taşeronların farklı çalışma takvimi olabileceği göz önüne alınarak farklı günlerde tatil yaparak çalışılması durumunda işin kaç takvim günü süreceği hesaplanmıştır. Buna ek olarak hava koşulları ve Ramazan ayı gibi etkenlerin de iş verimine etkisi dikkate alınmıştır. Şantiyede aynı anda çalışabilecek işçi sayısı, taahhüt edilen proje teslim süresi ve gecikme cezasına göre en uygun iş programının hazırlanması Tavlama Benzetimli Genetik Algoritma (TBGA) ile gerçekleştirilmiştir. Bu çalışmada kaynak kısıtlı iş programı ve zaman maliyet ödünleşim problemleri oluşturulurken proje paydaşlarının farklı çalışma günlerinin olabileceği ve iş verimlerinin mevsim koşullarına göre değişebileceği dikkate alındığı için inşaat projelerinin iş programlarının, daha fazla etkeni içerir biçimde oluşturulabilmesi sağlanmıştır. Bu yaklaşım etkin yapım yönetimi tekniklerinin hızlı biçimde uygulanmasını sağlamaktadır.
Virtual Grand Round in Medical Education: A Literature Review Based on Medical Universities Experiences
Authors: Boushehri Elham , Latifi Masoomeh , Davoodi Somayeh , Jahandideh Fouad , Khorrami Farid
Published: October 2022

This study tries to review the experience of universities in detecting patterns that have been followed in holding Grand Rounds by them and achieving the set of factors needed to hold this event with high quality. In this literature review study, 268 titles of English articles were collected between 1960 and 2021 in the international databases of Cochrane, ERIC, PubMed, Scopus, Science Direct, Embase, and Web of Science. The keywords included "Grand Round," "Medical Grand Round," "Virtual Grand Round," and "digital Grand Round." Based on the PISISMA diagram guide, after "quality review," eight articles remained in the study. Traditional content analysis methods were used to extract data, which was then inductively classified as a four-phase-ADDIE model, which includes Analysis, Design, Implementation, and Evaluation. In other words, the ADDIE model is used as a guide in determining the quality status of the virtual grand design of other studies. The analysis is always one of the main phases of the ADDIE model, so the information in this main theme was essentially divided into two sub-themes: "teaching facilities" and "conditions," in which all the measures are taken to assess the feasibility of the course were included. In the "implementation" theme, just one article described the complete format of holding a virtual grand round, emphasizing the teaching method, case type, and presentation platform. In the "evaluation" theme, all eight articles evaluated the results of the virtual course in some way using student perspectives. A deeper review of the experiences showed that no specific and complete instructional design model was used to design and implement this program. In this review, it was found that the documented experiences regarding holding this program in virtual mode are very limited. Besides, the lack of applying an instructional model effectively makes the citation challenges.
Evaluation Tools for Digital Educational Games: A Systematic Review
Authors: Mousavi Baigi Seyyedeh Fatemeh , Norouzi Aval Reyhaneh , Sarbaz Masoumeh , Kimiafar Khalil
Published: October 2022

This systematic review investigates various evaluation tools for digital educational games and answers the question of which evaluation tools could be used to evaluate digital educational games. A systematic review of studies, by searching for related keywords in the title, abstract, and keywords of studies in the scientific databases EMBASE, Web of Science, Scopus, and PubMed, was launched without time-limited on November 2, 2021. The same checklist was used to extract data such as reference, first author's name, year of publication, tool name, type of tool, instructional strategy, and evaluation factors. A total of 3516 articles were extracted and finally, an analysis of the included studies gave us 22 different approaches to the systematic evaluation of educational games. The same study developed some proprietary evaluation tools exclusively for game evaluation. However, some tools evaluated games in different dimensions, most of which did not consider the tool's validity. In the same sense, we have five prominent evaluation guidelines, including E-GESS, MEEGA+, EGameFlow, HEP, and Kato evaluation guideline, all of which have been developed by explicitly decomposing the evaluation objectives into criteria and using a questionnaire assessed through a collection of case studies. Our systematic review showed the need to identify more consistent and uniform patterns in different dimensions for the systematic evaluation of digital educational games to achieve valid results that can be used as a basis for deciding on the use of digital educational games.
Herpes Zoster Ophthalmicus and Encephalitis Following Botulinum Toxin Type A Injection for Blepharospasm: A Case Report
Authors: Farahmand Ghasem , Magrouni Hanna , Zolfaghari Vahid , Gharehjeh Sina , Ranji-Burachaloo Sakineh
Published: October 2022

A 68- year – old male was admitted to ER of Referral Imam Khomeini hospital with abrupt commence of fever accompanied with debilitating non-radiating headache, photophobia, ataxia and cluster of confluent vesicles on right side of forehead with swelling of right eyelid. All his symptoms started after receiving Botulinum injection on the same week before admission and he had never had similar manifestations beforehand.
His medical history was remarkable for hyperlipidemia, hypertension and right side Blepharospasm for which he received Botulinum injection every 6 months. He was on medication for the rest of his medical problems. He was not on any immunosuppressive medication and did not suffer from any disease weakening the immune system. His family history was unremarkable for any similar problems.
In medical exam, he was ill but not toxic, his vital signs were blood pressure of 135/80 mmHg, heart rate of 76, respiratory rate of 17 and oral temperature of 38.5Ĉ. He had vesicles on his right forehead. Heart sounds were regular without murmur. Lungs were clear. Abdominal examinations were inconspicuous.
In neurological examinations, he was confused and disoriented to time and place. Cranial nerves were without any pathological findings except for positive Marcus Gunn of affected side and blurring of right optic disk margin. No muscle atrophy was seen. Muscle force showed no weakness. He was ataxic. Sensory examination was normal. Reflexes were checked and were within normal limits and symmetric.
Computer tomography (CT) scan of head was unremarkable and his MRI scan did not reveal any information compatible with his symptoms.
Due to the sudden onset of fever with headache and confusion, encephalitis was suspected and empirical therapy with antibiotics was started and LP was performed which indicated pleocytosis in CSF. According to the vesicles on the skin and with suspicion of Varicella encephalitis, PCR was sent for diagnosis of VZV. Subsequently, his condition got dramatically better and symptoms diminished after acyclovir was started.
A Rare Entity of Gall Bladder: Ectopic Liver (Choristoma)
Authors: Yildirim Mehmet , Argon Asuman , Cekic Ahmet
Published: October 2022

Ectopic liver is defined as the presence of normally organized liver tissue outside its normal location. It is frequently found in the gallbladder. Ectopic liver is normally asymptomatic and only discovered incidentally. We report a case of 51- year- old woman with ectopic liver and we also review the characterization of this rare entity .This report adds another case to the very rarely reported ectopic liver located in the gallbladder.
Respiratory Distress Due to Giant Pulmonary Hydatid Cyst
Authors: Ershadi Reza
Published: October 2022

Pulmonary echinococcosis most frequently occurs in the right and both lower lobes. Children are more likely to develop pulmonary rather than hepatic echinococcal cysts.  Some evidence suggests that echinococcal cysts develop more rapidly in the lungs of children than those of adults, which may explain the more common appearance of pulmonary cysts in children. Younger patients have larger cysts owing to their greater tissue elasticity. Large pulmonary hydatid cysts are critical because they pose a higher risk of rupture. Herein, we present an eight-year-old girl presented with severe respiratory distress due to giant hydatid cyst of right lung with shift of the mediastinum at left. The lesion displaced the trachea at left. The patient was successfully treated by parenchymal-saving operation. In conclusion, Giant hydatid lung cysts represent a distinct clinical entity most frequently encountered in children and adolescents with more serious symptoms. Although non-complicated giant hydatid cysts have a good prognosis regardless of their size and can be safely treated by parenchyma-preserving surgery.
Analysis of the Problems Associated with the Learning of Mathematics By Students in Higher Basic Education At the “Ciudad De Alausí” School
Authors: Flores Cesar Vicente Lara
Published: October 2022

Throughout history, difficulties in learning mathematics have become a major concern of many professionals dedicated to the world of education, especially if we consider the high percentage of students failing the subject. However, the increasingly technologically inclined society demands high levels of competence in the area of mathematics. Therefore, the objective of this research was to identify the situation that students of Higher Basic Education of the “Ciudad de Alausí” school go through and recognize the complications that hinder students’ learning and concentration in understanding Mathematics. An exploratory investigation of virtual classes indicated that students find it difficult to understand mathematical concepts because the classes are monotonous and other teaching methodologies are not used, causing them stress and overwhelm.
Keywords: virtual classes, mathematics, research, higher basic education, education, learning difficulties, stress, burden.
Resumen
A lo largo de la historia las dificultades en el aprendizaje de las matemáticas se han convertido en una preocupación manifiesta de buena parte de los profesionales dedicados al mundo de la educación, especialmente si consideramos el alto porcentaje de fracaso que presentan en estos contenidos los alumnos que terminan la escolaridad obligatoria. A esto hay que añadir que la sociedad actual, cada vez más desarrollada tecnológicamente, demanda con insistencia niveles altos de competencia en el área de matemáticas. La presente investigación se planteó como objetivo identificar la situación por la que pasan los estudiantes de Educación Básica Superior del colegio “Ciudad de Alausí”, reconocer los principales problemas que se presentan en la asignatura de Matemática que dificulta el aprendizaje de los estudiantes y su concentración en clases virtuales y conocer que actividades o herramientas mejorarían su enseñanza, mediante una investigación exploratoria, que nos indicó que los estudiantes se les dificulta el aprendizaje debido a que las clases son monótonas y no se utiliza otras metodologías de enseñanza causándoles estrés y agobio.
Palabras Clave: clases virtuales, matemática, investigación, educación básica superior, educación, dificultades de aprendizaje, estrés, agobio.
The Insatiable Demand for Cheese in the Market of Cumbe Parish
Authors: Aguinda María del Carmen Manitio , Marisol Oña Unaucho Evelyn , Yampik Mario Froilan Guajare , Zambrano Victoria Micaela Segovia
Published: October 2022

In the cheese market of the Cumbe parish, many cheese brands are positioned as consumer favorites, which has been the motivation behind the creation of various projects focused on the production and elaboration of cheeses. The present research aims to provide a better overview and knowledge of the viability of the project of elaboration and manufacturing of mature cheeses by the Austral Livestock Association in the parish of Cumbe of the Cuenca Canton. The main objective of the research was to understand the insatiable demand for cheese in the market and analyze the production process of the Austral Livestock Association. The study is based on the primary, secondary, and statistical data from the Parish Gad of Cumbe and the INEC. A survey comprising 11 questions helped determine the demand of cheese. The correct analysis, interpretation, and discussion of results helped to determine that the project in question has scope, and at the end of the investigation, it was concluded that through an exhaustive analysis it was possible to verify the viability of the projected statistical data of the supply and demand.
Keywords: demand, marked, supply, cheese, unsatisfied demand, cumbe.
Resumen
En el mercado de quesos de la parroquia de Cumbe están posicionadas muchas marcas de quesos como preferidas del consumidor, lo cual ha motivado a la creación de diversos proyectos enfocados en la producción y elaboración de quesos. Mediante la investigación realizada se obtuvo un mejor panorama y conocimiento de la viabilidad del proyecto de elaboración y fabricación de quesos maduros de la Asociación Ganadera Austral de la parroquia de Cumbe del Cantón Cuenca. En la investigación el objetivo principal es conocer el nivel de la demanda insatisfecha de la producción de quesos, para realizar un estimado de producción de la Asociación Ganadera Austral con su proyecto, los métodos utilizados para la investigación se basaron en las fuentes primarias, secundarias y en datos estadísticos del Gad Parroquial de Cumbe y del INEC. Mediante estos métodos se pudo utilizar la técnica de la encuesta, la cual consta de once preguntas, con diferentes tipos de incógnitas que ayudaron a determinar la demanda insatisfecha. El correcto análisis, interpretación y discusión de resultados, nos ayudan a determinar que el proyecto a realizarse tiene mercado en el sector, finalizando la investigación nos encontramos con las conclusiones que mediante un análisis exhaustivo se pudo constatar la viabilidad de los datos estadísticos proyectados de la oferta y demanda obtenido como resultado final la demanda insatisfecha.
Palabras Clave: demanda, marcado, oferta, queso, demanda insatisfecha, cumbe.
Digital Communication and Its Influence on Consumer Habits During Health Emergencies
Authors: S Trujillo , P Moyano , J Carrasco
Published: October 2022

Virtual Social Networks, such as Facebook, text messages, and instant messaging, have produced a great flow of real-time data like never seen before. This has turned multitasking into an information management strategy (Campos, 2018, p. 5). Currently, social networks have become a massive economic medium and generated many expectations due to the growth potential they offer. The sample of this study was made up of 213 marketing students of the Polytechnic School of Chimborazo – 110 female and 103 male students from the Coast, Sierra, and Amazon regions. Results show that digital communication informs and influences the decision of a consumer to purchase goods and services.
Keywords: digital marketing, consumers, services, social networks.
Resumen
Las Redes Sociales Virtuales, tales como Facebook, mensajes de texto y mensajería instantánea han producido un gran flujo de datos en tiempo real, como nunca antes se vio. Lo que ha convertido a la multitarea en una estrategia de gestión de la información. (Campos, 2018, pág. 5), en la actualidad las redes sociales se han convertido en un medio económico, oportuno y masivo, y han generado muchas expectativas por el potencial que brindan al desarrollo de las diferentes funciones en una organización. La muestra objeto de estudio la constituyeron 213 estudiantes de la Carrera de Mercadotecnia de la Escuela Superior Politécnica de Chimborazo, 110 educandos del género femenino y 103 del género masculino y pertenecen a las regiones Costa, Sierra y Amazonía. Los resultados obtenidos muestran que la comunicación digital informa e influye en la decisión de compra de bienes y servicios sin que los mismos se encuentren estrechamente relacionados con la satisfacción de sus necesidades elementales.
Palabras Clave: marketing digital, consumidores, servicios, redes sociales.
A Homogeneous Ensemble of Robust Pre-defined Neural Network Enables Automated Annotation of Human Embryo Morphokinetics
Authors: Danardono Gunawan B. , Erwin Alva , Purnama James , Handayani Nining , Polim Arie A. , Boediono Arief , Sini Ivan
Published: October 2022

Background: The purpose of the current study was to reduce the risk of human bias in assessing embryos by automatically annotating embryonic development based on their morphological changes at specified time-points with convolutional neural network (CNN) and artificial intelligence (AI).
Methods: Time-lapse videos of embryo development were manually annotated by the embryologist and extracted for use as a supervised dataset, where the data were split into 14 unique classifications based on morphological differences. A compilation of homogeneous pre-trained CNN models obtained via TensorFlow Hub was tested with various hyperparameters on a controlled environment using transfer learning to create a new model. Subsequently, the performances of the AI models in correctly annotating embryo morphologies within the 14 designated classifications were compared with a collection of AI models with different built-in configurations so as to derive a model with the highest accuracy.
Results: Eventually, an AI model with a specific configuration and an accuracy score of 67.68% was obtained, capable of predicting the embryo developmental stages (t1, t2, t3, t4, t5, t6, t7, t8, t9+, tCompaction, tM, tSB, tB, tEB).
Conclusion: Currently, the technology and research of artificial intelligence and machine learning in the medical field have significantly and continuingly progressed in an effort to develop computer-assisted technology which could potentially increase the efficiency and accuracy of medical personnel’s performance. Nonetheless, building AI models with larger data is required to properly increase AI model reliability.
An Incidental Detection of a Cryptic Complex Chromosome Rearrangement Found During NGS Based PGT-SR: A Case Report
Authors: Özer Leyla , Aktuna Suleyman , Unsal Evrim , Baltaci Aysun , Baltaci Volkan
Published: October 2022

Background: Complex chromosome rearrangements (CCRs) involve more than 2 chromosomal breakpoints and cause the exchanges of chromosomal segments between two or more chromosomes. The carriers of CCRs have normal phenotypes, but they have a higher risk of reproductive failure.
Case Presentation: This paper presents a couple with a history of two affected children, one spontaneous abortion, three in vitro fertilization (IVF) failures, and one healthy boy who were referred to our laboratory for preimplantation genetic testing (PGT). The wife had been evaluated as a carrier of 46,XX,t (2;6)(p21;p25); therefore, four IVF treatment cycles supported with PGT for this translocation had been performed in different IVF centers until the couple consulted our laboratory. Only one of these four IVF attempts had resulted in a healthy boy and this IVF study had been performed with fluorescence in situ hybridization (FISH)-based preimplantation genetic testing for structural chromosomal rearrangements (PGT-SR). The fifth IVF study with next-generation sequencing (NGS)-based PGT was performed by our laboratory and no healthy embryo was found in evaluated 6 embryos. During our NGS-based PGT, the cryptic involvement of 12p was firstly detected. FISH with chromosome 2,6, and 12 specific probes revealed that the mother was a carrier of a balanced 3-way translocation of 46,XX,t(2;6;12)(p21;p25;p13). 
Conclusion: NGS based PGT-SR method is an accurate method for detecting the copy number variations and is helpful to find out the cryptic CCRs.
Successful Endovascular Rescue Using the Brockenbrough Needle Following Inadvertent Stent-Graft Deployment in the False Lumen
Authors: Rasalkar Pavan , Vemuri Krishna Santosh , Bootla Dinakar , Revaiah Pruthvi C , Mishra Anand Kumar , Dahiya Neelam , Ghosh Soumitra , Barwad Parag
Published: October 2022

Inadvertent deployment of stent grafts into the false lumen during thoracic endovascular aortic repair (TEVAR) is rare and is associated with catastrophic consequences. We present a case of accidental stent-graft deployment from the true lumen into the false lumen during TEVAR, resulting in hemodynamic collapse and visceral malperfusion. We successfully performed a bailout using the Brockenbrough needle to create new access from the true lumen to the false lumen and implanted another overlapping stent graft.
Features of Applying the Force Displacement Theory to the Contact Stiffness Calculation for the Spindle Angular Contact Ball Bearing Support
Authors: Frolov A.V.
Published: October 2022

Contact stiffness is an important parameter for describing the interaction of plenty precise engineering solutions, for example, for machine-tool manufacture, the most important element of the carrier system is the spindle assembly supports, largely determining the accuracy of machining parts on the machine. The article considers an example of a system approach to describing the variable stiffness of a high-precision spindle bearing, combining an analytical approach to calculating the variable quasi-static stiffness of an angular contact ball bearing and a methodological approach that takes into account the contact normal and tangential force displacements of the upper bearing ring while considering the friction force for tangential interactions. The proposed system approach to calculating the stiffness of a ball bearing support is based on fairly simple models, in particular, the apparatus proposed by Professor P.M. Chernyanskiy, describing the phenomena of changing the spindle supports stiffness. These changes were experimentally obtained and weren’t described in earlier works. It is shown that the experimental stiffness consists of elastic and contact components, depending on the friction forces, therefore, the concept of apparent stiffness is introduced for data that are not taken into account in the processes under study. The effect of the axial displacement of the spindle is explained on the basis of contact interactions in the support of the spindle unit. The resulting analytical system model was tested on well-known bearing supports and the obtained stiffness solutions were compared with validated experimental data from open sources
„Write as your ear hears it”: Text and pretext in the polyphonic reportages of Svetlana Alexievich
Authors: Karonta Anna
Published: October 2022

The article analyzes the process of incorporation of the witnesses’ verbal testimonies into the public sphere, of which polyphonic reportage is a part. This genre has become known mainly thanks to Svetlana Alexievich, whose works are based entirely on recorded conversations and interviews. Listening to the witnesses enables the reporter facing the dominant discourse of the past to reach out to others, the process of discovering and textualizing of which can be described with reference to the folk tradition of collective singing.
Distance learning technologies with blockchain elements in the system of continuous education
Authors: Kozhasheva Gulnar , Maltekbassov Marat , Baidildinov Talgat , Sakhipov Aivar , Gavrilova Yekaterina
Published: October 2022

The relevance of the study was explained by the fact that the support of management of the distance learning information processes is associated with the problem of effective allocation of system resources used upon transferring and processing of educational information. The purpose of this study is a comprehensive analysis and development of the principles of developing an electronic portal for the system for continuous education. In the work, the authors used general methods of generalization and systematization, as well as the method of mathematical calculations. 150 teachers of secondary and higher primary schools took part in the calculations. The results of the calculations made it possible to confirm the need to use distance learning technologies with blockchain elements in educational institutions. The use of blockchain technologies for the implementation of an electronic portal can increase the motivation of students and teachers, facilitating work in the learning process.
Keywords: continuous education, distance learning, blockchain, electronic portal, automation of learning.