bluuebunny/crossref_metadata_2025 huggingface dataset:
xLightGCN: A Simplified GCN-based Model for Multimedia Recommender System
Authors: JingLi  , Siegal Eithan , Wang Wenting , Libson Zichria , Maibach G.
Published: June 2022

With the gradual development of Internet technology, information resources are growing at a high speed and the problem of information overload has emerged. It is difficult for users to get the information they need directly and quickly from the massive amount of information. Therefore, recommendation algorithms are usually used to solve the problem of information overload, and the research of various recommendation methods. Depending on the implementation idea, recommendation algorithms are mainly classified into three categories: content-based recommendation, collaborative filtering-based recommendation, and hybrid recommendation methods. Collaborative filtering is the most widely used recommendation algorithm, and its main idea is to discover the correlation between users based on their preferences for products, and to make recommendations based on the correlation. Although these methods improve the performance of the recommendation system, when the number of users and products increases, the recommendation system may face the problems of sparsity and cold start, and thus cannot achieve personalized recommendation. The purpose of this paper is to leverage the multi-modal information to address the problem. Specifically, we devise a novel simplified GCN-based model which incorporates the content information extracted from the visual, acoustic, and textual modalities with CF signal by propagating along the item-user bipartite graph. Finally, conducting extensive experiments on public datasets, we demonstrate that our proposed model outperforms several state-of-the-art baselines.
Abulia major and Hypoactive Delirium in COVID-19 reversed with Methylprednisolone Pulse Therapy
Authors: Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia , Zanella Luiz Gonzaga Francisco de Assis Barros D’Elia
Published: June 2022

Background: Sars-CoV-2 is a member of the genus Betacoronavirus like the two other coronaviruses viz. SARS-CoV (severe acute respiratory syndrome coronavirus) and MERS-CoV (Middle East respiratory syndrome coronavirus). The SARS-CoV-2 infection has been associated with neuropsychiatric manifestations in acute and chronic COVID-19 (The Long COVID-19 Syndrome), bringing social consequences, and worsening people's quality of life. Overview: This article exemplifies two cases of neurological manifestations resulting from infection by Sars-CoV-2, reversed with Methylprednisolone in pulse - therapy regimen. The first case presents a young patient with symptoms like those existing in patients with Alzheimer's Disease, whose final and presumable diagnosis was Abulia major. The second case exemplifies an elderly person admitted to the hospital due to hypoactive delirium triggered by a urinary tract infection hypothesis. The final diagnosis was Hypoactive Delirium secondary to COVID-19, with urinary manifestations from the SARS-CoV-2 kidney injury. Aim and Conclusion: The purpose of this article is to warn about phenomena related to COVID-19, whose treatment can be performed with high doses of corticosteroids and with drugs that act positively on dopaminergic and serotonergic pathways. Patient exams and more information are available in the Appendix of this article.
Features of noble metals at Pioneer gold deposit
Authors: Radomskii S. M. , Radomskaya V. I.
Published: June 2022

The purpose of the present study is to evaluate the mass fractions of the group of noble metals (gold, silver, platinum, ruthenium, osmium, palladium, iridium, rhodium) in the ores and host rocks of the Pioneer deposit (the Upper Amur Region, Russia) and to determine their migration activity and hydrochemical classification of ore metals by sizes. The object of the study is primary and oxidized ores, as well as rocks hosting this mineralization. The study employs the method of quantitative chemical analysis, micro assay melting with an error of correctness, accuracy and reproducibility of the results of ≤30 %. Pioneer is a near surface hydrothermal deposit with oxidized and sulfide types of ores, which are processed both by the open method of alkaline heap cyanide leaching, and by the closed pressure method, respectively. A gold concentration plant was built to implement these processing methods. The main recoverable component of this technology is gold, whereas silver and platinum group metals are present in industrial products as impurities. The technology is highly profitable, which allows cost-effective processing of ores with the mass fractions of 1–4 ppm of gold. The performed hydrochemical classification of the sizes of native gold minerals has showed that the bulk of the nuggets (74– 78 %) of primary, sulfide, and oxidized ores accounts for the fraction with the sizes of 160–1000 μm and 11–13 % account for the fraction with sizes of 16–40 μm. Fine gold of the deposit provides its complete dissolution during the cyanidation process.
Evaluation of methods and results of dredging waste and dump sampling at ore deposit
Authors: Azizkhonov I. M. , Talgamer B. L. , Usmonov N. K.
Published: June 2022

The purpose of the study is to assess the reliability of sampling results of concentration tailings at the experimental site of Tereklikan of Kanjol deposit (Tajikistan). The study involves the description of dredging waste and dumps of the site under investigation. The total length of the sampled interval is 12 m. It was divided into two local intervals of 4 and 6 m long according to geological features (amount of veined quartz material). Each type and component of the sampling process including the study of the mineral and chemical composition of ores is of utmost importance in the determination of the quality and quantity of the ore mass (ore), whereas the study of ore mineral and chemical composition is used during prospecting and exploration works for ore minerals (lead, zinc, tin, gold, copper, aluminum, manganese, etc.). The authors substantiate the feasibility for technogenic deposits formed under non-ferrous metals mining to be involved in operation. The methodology and channel sampling results are presented and the reliability of the latter is assessed. The methodology and results of physico-chemical research of concentration tailings via spectral analysis and atomic absorption method are given. The industrial significance of ancient dredging waste and dumps as well as the content of valuable components sufficient for their development has been established. An acceptable technology of dredging waste and dumps processing when involved into operation has been proposed.
PNEUMONIA SEVERITY INDEX COMPARED TO CURB-65 IN PREDICTING THE OUTCOME OF COMMUNITY ACQUIRED PNEUMONIA -A PROSPECTIVE STUDY
Authors:   Senior Resident Dept ofRespiratory Medicine Govt Medical College, Kannur., Ravindran Rishna , M. Rajani ,   Professor Dept Of Respiratory Medicine Govt Medical College, Kannur., D.K. Manoj ,   Professor & HOD Dept Of Respiratory MedicineGovt MedicalCollege, Kannur., Shafeek K. Muhammad ,   Assistant Professor Dept Of Respiratory Medicine Govt Medical College, Kannur., K.V Padmanabhan ,   Assistant Professor Dept Of Respiratory Medicine Govt Medical College, Kannur.
Published: June 2022

Introduction: Community-acquired pneumonia (CAP) is a leading cause of morbidity and mortality worldwide. Several severity scores have been proposed to guide initial decision making on hospitalization and to predict the outcome. Pneumonia Severity Index (PSI) and CURB 65 are the two most widely used scoring systems to prognosticate pneumonia. Objectives: Tocompare the efficacy of PSI and CURB 65 scoring systems in prognosticating the outcome in cases of CAP. Methods: This is a prospective study conducted over a period of one year on 150 patients who presented with community acquired pneumonia on the grounds of their clinical and paraclinical findings in our institution under the Department of respiratory Medicine, and fulfilling the inclusion and exclusion criteria. The patients were classified as per CURB 65 and PSI system and their outcome compared. Results: We studied 150 patients with community-acquired pneumonia (114 men, 36 women). In our study 100 % of patients in CURB 65 class 4 and 5 required ICU admission and death was 84.6% and 100% respectively. Majority of patients of PSI class 4 and 5 needed ICU admission 67% and 96% respectively and death was 16% and 58% respectively. The sensitivity and specificity of CURB-65 class â‰¥3 in predicting mortality were 79% and 89%, respectively (AUC 0.92). As for pneumonia severity index class â‰¥4, the rates were 79% and 84%, respectively (AUC 0.86). The mortality rate and need for ICU admission increased progressively with increasing scores. Conclusion: CURB-65 seems to be the preferred method to predict mortality and need for ICU admission in patients with community-acquired pneumonia.
ISOLATION AND CHARACTERIZATION OF PLANT GROWTH PROMOTING HALOTOLERANT BACTERIA FROM SALINE RHIZOSPHERIC ENVIRONMENTS
Authors:   Department of Botany, Andhra University, Visakhapatnam., Sreelakshmi B. , Sujatha B. ,   Department of Botany, Andhra University, Visakhapatnam.
Published: June 2022

Among the abiotic stress parameters salinity is the major problems to the agriculture in coastal areas. Salinity leads to stunted growthand reduced yields.Bacteria isolated from saline environmentswere physiologically adapted to saline conditions, such tolerant microorganisms provide a means of cultivation of crops in salinity influencedareas. Halotolerant bacteria which have the plant growth promoting activity, plant growth promoting bacteria(PGPB) may be used to mitigate the effect of salinity in the field. Soil samples were collected from the high saline environments from Visakhapatnam and Kakinada coast. A total 7 morphologically different bacteria were isolated, among them isolate-07 was found to be high salt tolerant and plant growth promoting rich bacteria. All bacteria were biochemically characterized and isolate-07 was characterized by 16s rRNA gene sequencing and confirmed as Bacillus megaterium.
EVALUATION OF CYTOTOXIC AND GENOTOXIC EFFECTS OF SAXAGLIPTIN
Authors:   CanakkaleOnsekiz Mart University, Canakkale Vocational School of Health Services, Department of Medical Services and Techniques, Canakkale, Turkey., Ali Berber Ahmet , Berber Nurcan ,   CanakkaleOnsekiz Mart University, Canakkale Vocational School of Health Services, Department of Pharmacy Services, Canakkale, Turkey., Uysal Ibrahim ,   CanakkaleOnsekiz Mart University, Canakkale Vocational School of Health Services, Department of Medical Services and Techniques, Canakkale, Turkey., Akinci Kenanoglu Nihan ,   CanakkaleOnsekiz Mart University, Faculty of Arts and Sciences, Department of Biology, Canakkale, Turkey.
Published: June 2022

Saxagliptin (SAX) is an oral drug that is a hypoglycemic (between an anti-diabetic agent) dipeptidyl peptidase-4 inhibitor. In this study, cytotoxic, genotoxic effects and DNA damage of SAX on human lymphocytes were investigated. For this purpose, Single Cell Gel Electrophoresis (SCGE), Micronucleus (MN) and Mitotic Index (MI) tests were used. Based on the daily doses of SAX, 0.017, 0.035, 0.07, 0.14 Âµg/mL concentrations used for the study. SAX significantly reduced the MI only at the highest concentration (0.14 Âµg/mL) for 24 hours, and 0.07- and 0.14-Âµg/mL concentrations for 48 hours. SAX did not cause a statistically significant change in MN frequency (except for concentration 0.14 Âµg/mL). In the SCGE test, a statistically significant increase of comet tail length was observed at 0.07- and 0.14-Âµg/mL concentrations. SAX did not cause a statistically significant change in comet tail moment and tail intensity (except for concentration 0.14 Âµg/mL). As a result, SAX caused statistically differences in the SCGE, MI and MN tests only at the highest concentrations that are not recommended commercial use (except for tail length, 0.035 Âµg/mL). When the results of all these studies are evaluated together, it can be said that SAX has no aneugenic, mutagenic and clastogenic effects at daily doses in in vitro studies on human lymphocytes.
Participación ciudadana e incorporación del paradigma ambiental a la Constitución de la Nación Argentina
Authors: Ferro Mariano Damián
Published: June 2022

La temática de la participación ciudadana en materia ambiental ha sido motivo de un extenso tratamiento por parte de las ciencias sociales, especialmente referido a la proliferación de los conflictos ambientales desde la perspectiva de la ecología política, la justicia ambiental o de enfoques institucionalistas. En este artículo se analiza una cuestión poco tratada referida a la participación ciudadana en la introducción del paradigma ambiental a la Constitución de la Nación Argentina de la reforma de 1994. Se analiza el contexto institucional, socio histórico y la emergencia de los primeros movimientos ambientalistas en Argentina, ya que entendemos que la perspectiva histórica, de largo plazo, es un factor crucial para comprender la participación socio legal en cuestiones ambientales en el s. XXI. Finalmente, se caracteriza una serie de avances institucionales de gran relevancia sobre la participación ciudadana. Se sostiene la hipótesis que la participación ciudadana constituyó un factor operativo en la institucionalización del paradigma ambiental en la Argentina. El abordaje metodológico es de tipo bibliográfico-documental y se utilizó el análisis de contenido de textos normativos como técnica de análisis de datos.
Las manifestaciones del derecho a la libre determinación: una comparación entre el caso de Puerto Rico y el Tíbet
Authors: Ugarte Boluarte Krúpskaya Rosa Luz , Márquez Pretel Charlott Rosita Sadith
Published: June 2022

Mediante la presente investigación se busca explicar dogmáticamente el concepto de Derecho a la libre determinación estableciendo a los titulares, obligados y las formas de ejercicio señaladas en las resoluciones de la Asamblea General de las Naciones Unidas 1514(XV), 1541(XV) y 2625(XXV); advirtiendo las diferencias entre libre determinación y autodeterminación. Posterior a la delimitación conceptual dogmática, se aplican los conceptos en dos casos específicos: Puerto Rico y el Tíbet, estableciendo el momento en que ejercieron su Derecho a la libre determinación y si este ejercicio fue conforme con la normativa internacional. Se concluye como positivo el cambio del establecimiento estatal como único ejercicio del Derecho a la libre determinación, se define al Estado como un pueblo con ejercicio soberano y se advierte a la consulta popular como el instrumento recolector de la verdadera opinión de los pueblos.
El concepto de “guerra” en el derecho internacional de los derechos humanos y el derecho internacional humanitario: particularidades del caso argentino
Authors: Bucetto María Sol
Published: June 2022

Las definiciones brindadas en los instrumentos de Derecho Internacional Humanitario no proponen criterios lo suficientemente precisos para determinar de manera inequívoca el contenido de las categorías legales de conflictos armados. De este modo, otorga un amplio margen de apreciación para escapar de la protección del derecho humanitario y del respeto de los principios de humanidad, proporcionalidad y distinción. El caso argentino del régimen cívico-militar que se impuso durante los años 1976-1984 se constituye en un claro ejemplo de la “fragilidad” de la definición de los conflictos armados no internacionales y la escasa trascendencia de la intervención del Comité Internacional de la Cruz Roja.
Competencias de Tecnología e Innovación en la Enseñanza Híbrida
Authors: Medina Uribe Jury Carla , Huamani Chirinos Hubert Luque , Huamani Chirinos Bruger Gaston , Delgado Carbajal Lilian Amparo
Published: June 2022

En el presente artículo se realizó una revisión bibliográfica que tuvo por objetivo investigar las  competencias de tecnología e innovación en la enseñanza de la educación hibrida, siendo esta la integración de procesos virtuales que reemplazaran algunos de los procesos de la tradicional educación presencial, de tal manera que tanto la educación tradicional como la virtual estén integrados de forma conjunta. Para esto se realizó una revisión del estado del arte sobre las competencias de tecnologías e información indagando en la importancia de las mismas e identificándolas y a su vez expandiendo el contenido del tema de enseñanza híbrida a fin de poder dar referencias para futuros proyectos, concluyendo en la importancia de estas competencias de tecnologías e informaciónpara la enseñanza virtual.
La importancia de la investigación en la Universidad
Authors: Giles Ferrer Arturo Antonio
Published: June 2022

El autor trata en clave histórica, la relevancia de la investigación en el proceso formativo y aplicativo de cualquier profesión y el compromiso que tiene la universidad con ésta, así como las limitaciones formativas del abogado en esta materia.
From State to Province, The Ottoman Administrative Regulations in Baghdad During The 19th Century
Authors: MARUFOĞLU Sinan
Published: June 2022

In the 19th century, while the Ottoman Empire entered a western-style modernization process in the central-provincial relations and administrative organization of the state, on the other hand, it began to fall under the political and economic influence of the industrialized European states.

Baghdad, which governed as a salyaneli province in the Ottoman administrative organization since the 16th century, has seen a series of new administrative regulations after the removal of the Governor of Baghdad, Davut Pasha in 1831 and during the implementation of the Tanzimat process and the province system.

In this study, we will emphasize the administrative changes and administrative regulations implemented by the Ottoman Empire in the 19th century in Baghdad, during and after the transition from the state system to the new province system.
Potential and Challenges for Private Sector to Lead Warung Digitalization in Indonesia
Authors: Paradizsa Irlandi , Rahayu Ety
Published: June 2022

The purpose of this study is to understand the potential and challenges for the private sector to lead the process of warung digitalization to improve their business. MSMEs such as warung in Indonesia have been a tool for income generation for many people. Though the number of warungs that have leveled up is still minimum—most of their business are stagnant. This has resulted in their constant welfare situation. The approach used in this study is qualitative with the literature review method. This study finds that there is potential for the private sector to be the trailblazer in the digitalization process because of their characteristics and traits, the other actors’ situation, and the profit to be gained. Though, there are some challenges to be addressed, such as the lack of supporting infrastructure, minimal regulatory framework, and the need to train the warung owner.
Structural mechanics analysis of bolt joint of rigid flexible coupling manipulator
Authors: Zhang Wenhui , Wen Zhi , Ye Yangfan , Zhou Shuhua
Published: June 2022

As the key connecting part of the rigid flexible coupling manipulator, the structural dynamic characteristics of the bolted joint are analyzed by using the joint simulation technology of pro/e and ANSYS. Based on the spring equivalent principle, the finite element equivalent model of bolt joint is established, the relationship equation between contact surface pressure and bolt preload is derived, and its stress state is analyzed; Based on the micro convex deformation model and Hertz contact theory, the tangential stiffness equation and normal stiffness equation of the bolted joint are derived respectively. The three-dimensional model of the bolted joint is established by using pro/e and imported into ANSYS for joint simulation. The simulation experiments reveal the influence of bolt joint vibration characteristics under different conditions from the aspects of bolt diameter, pre tightening force, bolt group number and bolt distribution. The conclusions have important engineering value for the structural optimization of rigid flexible coupling manipulator.
Barreras de acceso para la reconstrucción mamaria inmediata de los senos: voces de las mujeres
Authors: Laza Vásquez Celmira
Published: June 2022

Introducción: la reconstrucción mamaria inmediata posterior a la mastectomía es un componente importante del tratamiento integral del cáncer de mama. A pesar de esto, en Colombia, las mujeres enfrentan diversas barreras para el acceso a esta etapa del tratamiento. Objetivo: comprender las barreras para el acceso a la reconstrucción mamaria inmediata que enfrentan las mujeres y las acciones desarrolladas para sortearlas, a partir de las voces de las mujeres y los cirujanos plásticos que las atendieron. Método: estudio cualitativo descriptivo realizado durante el año 2019, en la cual participaron 13 mujeres reconstruidas inmediatamente después de la mastectomía y residentes en el Departamento del Huila (sur de Colombia) y los 4 cirujanos plásticos de la región. La información se recopiló a través de un grupo de discusión y 10 entrevistas semiestructuradas que fueron analizados mediante la técnica del análisis temático. Resultados: emergieron tres temas: (i) Barreras administrativas de acceso a la reconstrucción mamaria inmediata, que describe las negaciones y demoras de las autorizaciones para el procedimiento quirúrgico; (ii) Acciones legales para enfrentar las barreras de acceso, dan cuenta de la obligación de las participantes de interponer recursos legales para el acceso a la atención; y (iii) Acciones no legales para enfrentar las barreras de acceso, fueron acciones individuales no legales que las mujeres desarrollaron paralelamente a la interposición de recursos legales. Conclusiones: este es un primer acercamiento cualitativo que reporta las dificultades de las mujeres para acceder a la reconstrucción mamaria inmediata producto de las barreras administrativas que imponen las aseguradoras; develando la urgencia de analizar la estructura del sistema de salud colombiano para el acceso a un tratamiento integral del cáncer de mama y de otros estudios que permitan aumentar la comprensión en el tema.
Enfermería líder en el mundo. Ahora más que nunca
Authors: Flórez Bedoya Alex Rogelio
Published: June 2022

Luego de la pandemia, nos enfrentamos ahora al poscovid-19, un período cargado de retos, desafíos y oportunidades. La crisis causada por la COVID-19 trajo consecuencia en diferentes áreas de la sociedad y la economía global. Las profesiones no resultaron ilesas ante este panorama. La pandemia puso de manifiesto la necesidad de invertir en enfermería para la seguridad sanitaria y económica mundial. El contexto actual y la mayor comprensión del estado de la enfermería en el mundo, brindan lecciones que invitan a considerar el papel de la enfermería y la forma que la profesión debería tomar en el futuro. Se requerirá, por lo tanto, de un liderazgo fuerte en enfermería, con compromiso para afrontar las carencias políticas, económicas y sociales que la pandemia ha puesto al descubierto y para hacer realidad la visión de un sistema de salud transformado, incluyente, justo, equitativo y diverso. El ritmo acelerado del cambio solo se puede manejar si se acompaña de líderes que puedan comprender el contexto actual para crear e implementar ideas innovadoras. Lograr ese liderazgo en enfermería permitiría el desarrollo de una prestación de servicios centrada en el paciente, la familia y los cuidadores, la creación de lugares de trabajo saludables, la garantía de niveles óptimos de satisfacción laboral, el bienestar entre los colegas y una clave para impulsar el cambio cultural, un elemento importante para garantizar una atención en salud de alta calidad y desde una perspectiva global.
Study of cardiotoxicity in patients with oncological pathology during chemotherapy
Authors: Melekhov S. , Gromashova E. , Tertyuk A. , Mansurova A. , Krasilnikov S.
Published: June 2022

Background. Cardiological complications occur in 20% of all patients receiving chemotherapy for oncological diseases (the most severe are cardiac rhythm and conduction disturbances, myocardial ischemia and the development of heart failure), which complicates further high-quality antitumor therapy. In addition, 44% of all cancer patients have concomitant cardiovascular pathology, more often coronary artery disease and essential hypertension are detected. Carrying out cardiotoxic chemotherapy in this group of patients worsens the prognosis of concomitant disease.Aim. Conduct a retrospective analysis of 237 patients undergoing antitumor therapy at different stages of treatment. The analysis included those patients who received drugs with a mechanism of myocardial damage according to type 1 cardiotoxicity — doxorubicin, cyclophosphamide, Herceptin.Methods. Review of case histories of 237 patients treated in 2021 with doxorubicin (146 patients), cyclophosphamide (86 patients), Herceptin (5 patients).Results. The use of chemotherapy with the drugs listed above causes irreversible myocardial dysfunction due to the death of cardiomyocytes with the development of left ventricular dysfunction and heart failure, and also worsens the course of concomitant cardiovascular  pathology in patients. For more detailed data, further research is needed, which is continuously ongoing.Conclusion. To date, the fact of the negative impact of chemotherapy on the cardiovascular system is indisputable, however, detailed studies are required. At Meshalkin National Medical Research Center, it is planned to conduct an electrocardiography, an echocardiography with an assessment of the ejection fraction, a general longitudinal strain of the left ventricle myocardium and left ventricle diastolic dysfunction, laboratory tests (troponin T and I, B-type Natriuretic Peptide (BNP), NT-proBNP) and also a comparison of these data with perfusion tomoscintigraphy of the myocardium of each patient undergoing chemotherapy treatment to identify early criteria for the development of cardiotoxicity after each cycle and at the end of chemotherapy, taking into account the total doses of drugs to obtain more accurate and up-to-date data.
Function of oculumotor, trochlear and abducens nerves in patients with cerebral aneurysms undergoing endovascular treatment
Authors: Semin P. , Kirillov L. , Kiselev R.
Published: June 2022

Background. Functional impairment of nerves, which move an eyelid, is a serious problem in patients with aneurysms, especially concerning enlarging number of endovascular procedures on cerebral aneurysms.Aim. To evaluate frequency of malfunction of oculomotor, trochlear, abducens nerves in patients with cerebral aneurysms.Methods. From 2019 to 2021 189 patients with 202 aneurysms underwent endovascular treatment. Location of the aneurysms: cavernous, clinoid and communicating segments of the internal carotid arteries, superior cerebellar arteries, P1 and P2 segments of the posterior cerebral arteries. Patients did not have dislocation syndrome as a result of a stroke. There were 37 male patients and 152 female patients. The age of patients ranged from 17 to 78 years, the mean age was 52±12 years. Distribution of aneurysm location: 42 (21%) – cavernous segment of the internal cerebral artery, 25 (12%) – clinoid segment, 110 (55%) – communicating segment, 18 (9%) – superior cerebellar arteries, 7 (3%) – P1 and P2 segments of the posterior cerebral arteries. Morphologically 11 (5%) of the aneurysms were fusiform, 191 (95%) of the aneurysms were saccular. 43 aneurysms (21%) were embolized with coils, 49 (24%) were treated using assisted coiling (balloon- and/or stent-assistance), 83 (42%) of the aneurysms were treated with flow-diverters. 27 (13%) patients underwent several endovascular procedures, including a combination of aforementioned techniques. Function of oculomotor, trochlear and abducens nerves was evaluated at the admission, during the hospitalization and at the discharge. Follow-up was achieved in 102 (54%) patients with 115 aneurysms, the mean follow-up period in June 2022 is 13 months. Checking cerebral angiography was performed 8months after the operation on the average.Results. In 89 (77%) patients checking cerebral angiography showed complete obliteration of the aneurysms, in 26 (23%) filling part of the aneurysm was found out to be smaller. 11 patients had preoperative oculomotor nerve paresis, after the procedure 1 patient had no oculomotor nerve impairment and made a complete recovery, 2 patients had partial improvement, 7 patients had no changes, in 1 patient paresis worsened. In our group we did not observe any case of trochlear nerve palsy either prior or after the operation during follow-up. 6 patients had preoperative abducens nerve paresis, after the treatment 1 patients had a complete recovery of abducens nerve function, 3 patients had partial improvement, 2 patients had no changes.Conclusion. In patients with cerebral aneurysms without cerebral dislocation as result of a stroke function of trochlear nerve did not suffer either prior or after endovascular treatment. Endovascular treatment in this category of patients may positively affect the oculomotor and abducens nerve impairment, but in rare cases it can lead to deterioration of neurological deficit.
Impacts of High-Fiber Snack on Satiety Hormonal Responses and Glucose
Homeostasis in Healthy Volunteers
Authors: Sunarti  , Santoso Umar , Rubi Dianandha Septiana , Cahya Pramana Abrory Agus , Huriyati Emy , Yasmine Nadia
Published: June 2022

Background:

Dietary fiber decreases the glycemic index and produces short-chain fatty
acids (SCFAs) that will affect gastrointestinal hormone secretion, such as glucagon-like peptide-
1 (GLP-1) and peptide YY (PYY). This study investigated the effects of high-fiber snacks
on the glycemic index (GI), GLP-1, PYY, and ghrelin secretions.

Materials and Methods:

The study involved ten participants who received both 42 g of tested
snack and glucose solution as a standard by washout period for a week. The standard glucose
was prepared by dissolving 50 g of glucose powder in 200 mL of water (200 kcal), while 42 g of
snack (195.8 kcal) containing 11.70% fiber from arrowroot, pumpkin, sweet potato, and cassava.
The blood samples were collected at 0, 30, 60, 90, and 120 minutes after consuming snacks or
standard glucose.

Results:

The GI of the tested snack is 69.14, which is categorized as medium. The area under the
glucose curve of the tested snack was lower compared to standard glucose (p= <0.001), and the
plasma glucose was lower than standard glucose. Compared to standard glucose, the tested
snacks had the area under the insulin curve lower than standard glucose, but it was not statistically
significant (p= 0.082). No statistically significant difference was also found in the GLP-1,
PYY and ghrelin concentrations between both standard glucose and tested snack intervention
(p= 0.948).

Conclusion:

Our results suggest that consuming high-fiber snacks with a medium glycemic index
may have no effect on GLP-1, PYY, and ghrelin, otherwise, it could improve glucose and
insulin homeostasis.
Subversion of the Oral Microbiota and Induction of Immune-Mediated Systemic
Inflammation with Special Reference to Periodontitis: Current
Knowledge and Perspectives
Authors: Santacroce Luigi , Muzio Eleonora Lo , Bottalico Lucrezia , Spirito Francesca , Charitos Ioannis Alexandros , Passarelli Pier Carmine , Jirillo Emilio
Published: June 2022

Under steady-state circumstances, the oral microbiota is in equilibrium with host tissues,
thus contributing to local and systemic health. Any interruption of such equilibrium leads
to a condition of dysbiosis with the proliferation of oral pathogens able to cause gingivitis and
periodontal disease. The mechanisms of periodontitis will be described, mostly emphasizing the
noxious effects exerted by oral pathogens on the periodontium either directly or indirectly via the
release of an array of mediators, even including pro-inflammatory cytokines, chemokines, and
enzymes. The persistence of local inflammation ultimately leads to systemic inflammation; therefore,
the link between periodontitis and obesity, diabetes and cardiovascular disease will be elucidated.
Some natural compounds, such as polyphenols, prebiotics, and probiotics, will be discussed
for their ability to exert anti-inflammatory and anti-oxidant activities in the context of the
inflamed buccal cavity and systemically, as well as for their modulation of the altered gum-gut
microbiota.
Distribution of Leukocidins, Exfoliative Toxins, and Selected Resistance Genes Among Methicillin-resistant and Methicillin-sensitive Staphylococcus aureus Clinical Strains in Egypt
Authors: Elbargisy Rehab Mohammed
Published: June 2022

Background:

Infection with Staphylococcus aureus (S.aureus) is an increasing health problem worldwide. This pathogen has multiple virulence factors that contribute to its pathogenesis in a wide range of diseases. The present study aimed to investigate the prevalence of leukocidins, exfoliative toxins, and common antimicrobial resistance genes among Methicillin-Resistant Staphylococcus aureus (MRSA) and Methicillin-Sensitive Staphylococcus aureus (MSSA) strains collected from various clinical sources in Egypt.

Methods:

Isolates were identified as S.aureus by the standard microbiological methods. Methicillin resistance was detected phenotypically by cefoxitin disc diffusion method and genotypically by PCR for detection of mecA gene. PCR was also used to detect the presence of leukocidin genes (LukD, LukE, LukF-PV, and LukS-PV), exfoliative toxin genes (eta and etb), and antibiotic resistance genes (tetK, tetM, ermA, ermC, msrA, and aacA-aphD).

Results:

About 50.5% of tested isolates were methicillin resistant by cefoxitin disc assay, while mecA gene was amplified in 64.6% of isolates. The highest prevalent toxin gene was lukE (93%) and the least prevalent one was eta (1%). The resistance genes tetK and tetM were detected in nearly 50% of the tested strains but lower prevalence rates were recorded for aacA-aphD, msrA, ermA, and ermC genes.

Conclusion:

Methicillin resistance was highly prevalent among tested S.aureus strains. Regarding the studied virulence and resistance genes, no significant difference was detected between MRSA and MSSA strains, except for ermA gene p<0.05 which was highly prevalent in MRSA strains. So, the variation between MRSA and MSSA strains in the response to treatment may be attributed to the resistance of MRSA strains to all β-lactams in addition to other possible acquired resistance mechanisms. Accordingly, fewer options of antimicrobial medications are available to treat MRSA infections.
Textile Wastewater Treatment Modelling and Design Using Stoat Graph and Summary Statistic Model
Authors: Akuma Desalegn Abdissa , Hundie Ketema Beyecha
Published: June 2022

Without properly treated wastewater released from the textile industry contains organic and inorganic pollutants that cause environmental problems like water body contamination, which causes marine life disappearance, soil contamination, and air pollution. Treatment of textile industry wastewater is difficult due to pollutant types existing like BOD, COD, toxic heavy metals, organic particle matter, inorganic particle matter, color, etc. The multi-component wastewater pollutant needs proper designs to remove such pollutants. Dire Dawa textile wastewater treatment plant (design) and simulation was the objective of this study. The method of this study was experimental and software modelling. STOAT model software is the best capable of simulation treatments plants, and the time to complete the simulation was 3 days. The STOAT graphic and statically data analysis model efficiently removed the multi-components of pollutants effluent from Dire Dawa textile industry. Some pollutant parameter measures before design model are SS 350 mg/L, DS 2000 mg/L, ammonia 55 mg/L, BOD 350 mg/L, nitrate 0 mg/L and DO 12 mg/L. The effluent of wastewater treatment plant model simulation results are 2 mg/L SS, ammonia 8.82 mg/L, BOD 2.5 mg/L, and nitrate increases from 0 to 58 mg/L by ammonia oxidation. Totally 98.7% SS, 99% BOD, and 84% ammonia were removed in the design model. In the sludge outlet, nitrate contents increase due to nitrification being processed rather than denitrification.
Assessment of Physicochemical Parameters of Surface Water of Karnaphuli River in Bangladesh Towards Identification of Potential Sources
Authors: Al-Razee A.N. M. , Harun Halima Binte , Jhumur Anowara Khanam , Ferdousi Farhana Khanaam , Zulfajri Muhammad , Habib Ahsan
Published: June 2022

In this study, water samples collected from Karnaphuli River, Chittagong, Bangladesh, were analyzed to assess physicochemical parameters to identify the possible potential sources of pollutants. Physicochemical parameters such as pH, alkalinity, acidity, conductivity, TDS, turbidity, total hardness, BOD, COD, ammoniacal-nitrogen, and sodium and chloride were varied from 3.05 to 9.34, 36.50 to 182.50 mg/L as CaCO3, 0.00 to 78.00 mg/L as CaCO3, 9.75 to 13.11 mS/cm, 6.36 to 10.40 g/L, 6.70 to 150.30 NTU, 1.37×103 to 1.95×103 mg/L as CaCO3, 5.50 to 45.50 mg/L as O2, 10.00 to 185.00 mg/L as O2, 0.00 to 12.60 mg/L as NH3-N, 2.27×103 to 2.92×103 mg/L and 3.12×103 to 4.60×103 mg/L in the water samples, respectively. Acidity, TDS, turbidity, total hardness, BOD, COD, and sodium were all very high near the TSP fertilizer factory’s point source (site-2), while pH, alkalinity, NH3-N, and chloride were very high at KAFCO (site-11). At site-11, BOD and COD levels were also elevated. The results indicate that untreated fertilizer effluents contaminated river water significantly. Pearson correlation matrix for physicochemical parameters and sodium and chloride was also calculated to confirm the potential sources of pollutants in the river water. TSP plant effluent has been shown to cause acidity, TDS, turbidity, BOD, COD and sodium in river water, whereas ammonia-urea plants are found to cause high pH, alkalinity, NH3-N, as well as BOD and COD in the Karnaphuli River.
Optimization and Validation of HPLC-DAD Method for the Quantification of Curcuminoids in Turmeric (Curcuma Longa L.)
Authors: Şap Ayşe , Yaman Mehmet
Published: June 2022

Curcumin and its derivatives named curcuminoids are naturally occurring polyphenolic compounds extensively marketed as a nutraceutical. The wide therapeutic potential of curcumin is highly explored by the authors. Therefore, pharma industries made many clinical inventions to bring it to the market as a drug. In this study, a simple, rapid, and sensitive High Performance Liquid chromatographic (HPLC) method for simultaneous determinations of curcumin, desmethoxycurcumin (DMC), and bis-desmethoxycurcumin (BDMC) was optimized and validated. Separation of curcumin, DMC, and BDMC was performed using the C18 column. Six factors, including the solvent type, ratio of mobile phase, flow rate of mobile phase, column temperature, injection volume, and wavelength, were investigated. The LOD and LOQ were observed to be 0.001 and 0.003 mg/L, R2 value < 0,99, respectively. RSD (%) is 0.974 for inter-day, and 1,312 for intra-day. Taking into consideration the retention time, peak area, resolution, and tailing factor, the optimum conditions were preferred: methanol as solvent, THF/Citric Acid (40/60) as mobile phase, flow rate of mobile phase at 0.5 mL/min, temperature of column at 30oC, injection volume at 20 µL and wavelength at 425 nm. The method is further used to determine ppm levels of curcumin derivatives, and recovery was found to be 90%. The proposed analytical method can be used for the quantification of curcumin in medicinal plants.
APLIKASI MIKORIZA GRANUL DAN POWDER MENGGUNAKAN TEKNIK COATING PADA JAGUNG MANIS (Zea mays L. Saccharata) DI TANAH LATOSOL DAN REGOSOL
Authors: Hazra Fahrizal , Istiqomah Fatimah Nur , Agus Hetty Novita
Published: June 2022

The demand for sweet corn increases over time. To increase sweet corn production, many farmers often use inorganic fertilizers excessively. Excessive use of inorganic fertilizers can have a negative impact on soils. One of the efforts that can be made to increase sweet corn production is the provision of biofertilizers, such as mycorrhizae. This study used a completely randomized design (CRD) with two factors. The first factor was the application of fertilizer with 7 levels of treatment, namely Control; NPK fertilizer + organic fertilizer; NPK fertilizer + organic fertilizer + 2.5 g mycorrhizal granules; NPK fertilizer + organic fertilizer + 5 g mycorrhizal granules; NPK fertilizer + organic fertilizer + 2.5 g mycorrhizal powder; NPK fertilizer + organic fertilizer + 5 g mycorrhizal powder; and NPK fertilizer + organic fertilizer + mycorrhizal powder (coating). The second factor was two different soils used as growing media, namely Regosol and Latosol from Dramaga. This study was carried out in five replications. The parameters observed were plant height, stem diameter, plant biomass, root colonization, soil available P, and total P in plants. The results showed that the application of mycorrhizal powder with coating techniques increased the growth of maize plants, the level of root colonization, the availability of soil phosphorus nutrients, and plant phosphorus uptake by the plants.
HUBUNGAN KEMIRINGAN LERENG DAN PERSENTASE BATUAN PERMUKAAN TERHADAP LONGSOR BERDASARKAN HASIL SIMULASI
Authors: Saputra Rinovian Tri , Utami Sri Rahayu , Agustina Christanti
Published: June 2022

Landslide is the process of moving slope-forming material that moves out of the slope. Landslides cause adverse impacts, such as damage to residences, public facilities, death tolls, and damage to agricultural land. Factors for landslides are influenced by disturbing slope stability due to steep slopes, high rainfall intensity, and movement of soil, rock, or a mixture of both. The research was conducted at Agro Techno Park of Brawijaya University (silt loam texture soil) and the experimental field of Faculty of Agriculture Brawijaya University (clay texture soil). The landslide simulation tool used acrylic (100 cm x 50 cm x 75 cm), with an aluminum plate as a base for adjusting the slope. Artificial rain was set to be stable at an intensity of 70 mm hour-1. This study used a combination of three factors, namely soil texture (C: silt loam and J: clay); slope (L1: 40° and L2: 50°); and surface rock (B1: 25% and B2: 50%), so that there were eight treatments with ten repetitions. The landslide duration and volume were measured. The data obtained were then statistically analyzed through the normality test and the unpaired t-test. The results show that increasing slope gradient from 40° to 50° on silty loam texture with similar rock content at the soil surface resulted in 6 times faster and two times larger landslide volume. At a very steep slope, the effect of soil texture and % rocks at the surface would be smaller on landslide duration but became more significant on landslide volume. Generally, the landslide factors can be ranked from the most significant effect as follows: slope gradient, soil texture, and rocks coverage at the surface.
EVALUASI KESESUAIAN LAHAN KECAMATAN KARANGREJA KABUPATEN PURBALINGGA JAWA TENGAH SEBAGAI UPAYA PENINGKATAN PRODUKTIVITAS KOMODITAS SAYURAN
Authors: Hidayah Anggraeni Nur , Budiyanto Susilo , Purbajanti Endang Dwi
Published: June 2022

Evaluation of land suitability was carried out in Karangreja sub-district to determine the land suitability class for vegetable commodities. This research was conducted to determine the limiting factors that resulted in a decrease in soil fertility in the local area. Land suitability classes were obtained in S2, S3, and N classes with limiting factors for water availability (wa), erosion hazard (eh), temperature (tc), root media (rc), and nutrient retention (nr). The limiting factor that’s spread evenly throughout the test area is the erosion hazard caused by the slope of the study area is classified as low to high. Improvement efforts as an agricultural area development that can be done are making drainage channels to improve the drainage system, making water absorption holes to reduce excess water on the land, making bench terraces to reduce slopes, and giving fertilizers in the form of zeolite or biochar to increase the level of soil cation exchange capacity.
ANALISIS STABILITAS AGREGAT DAN SIFAT FISIK TANAH DENGAN PENAUNG BERBEDA PADA SISTEM AGROFORESTRI DI LAHAN KOPI SUMBERMANJING WETAN, KABUPATEN MALANG
Authors: Hikmawati Rensy Faradina , Prijono Sugeng
Published: June 2022

One of the damages that can occur in the soil structure is a decrease in aggregate stability. This study aimed to analyze the relationship between the stability of soil aggregates on a land by considering the level or type of land cover and the influence of several physical properties of the soil on coffee grounds. In this study there were four treatments with five replicates using a randomized block design at 2 depths, namely 0-20 cm deep and 20-40 cm deep. The treatments were based on different types of shade plants, namely P1 (cocoa shade), P2 (sengon shade), P3 (lantoro shade), and P4 (gamal shade). The results showed that lowest and highest soil aggregate stability values at the top depth (0-20 cm) were found in treatment P1 (cocoa shade) of 1.76 mm and P4 (gamal shade) of 3.33 mm. While at the depth of 20-40 cm, the highest and lowest values were found in the treatment P3 (lamtoro shade) of 1.92 mm and P1 (cocoa shade) of 2.37 mm. The stability of soil aggregates significantly affected soil bulk density, specific gravity, porosity, and organic matter. All treatments gave a significant effect on the thickness of the litter. The highest and lowest values were found in the treatment P4 (shade gamal) and P2 (shade sengon) of 3.4 cm and 1.7 cm, respectively.
PENENTUAN PEMETAAN KADAR AIR TANAH OPTIMAL PADA LAHAN PERKEBUNAN KELAPA SAWIT (STUDI KASUS: KEBUN CIKASUNGKA, PT PERKEBUNAN NUSANTARA VIII, CIMULANG, BOGOR)
Authors: Zauhairah Siti Faizah , Barus Baba , Wahjunie Enni Dwi , Tjahjono Boedi , Murtadho Alfin
Published: June 2022

Soil water content is one of the dynamics of water conditions that can be a limiting factor in achieving optimal oil palm productivity. The extensive oil palm plantations make it difficult to acquire soil moisture content data. Soil water content conditions can be estimated by remote sensing technology through the vegetation and drought index, and also can be mapped using an interpolation approach. This study aimed to map the optimal soil water content in oil palm plantations based on Normalized Difference Vegetation Index (NDVI), Normalized Multi-band Drought Index (NMDI), and Interpolation. The results showed that the highest soil moisture was found on 0-3% slope gradient and the lowest on 8-15% slope gradient. Vegetation density based on NDVI analysis result was quite high, while the level of dryness based on NMDI analysis result was quite humid. Mapping of soil water content based on NDVI and NMDI had a very weak correlation with soil water content so both indices are less responsive in describing soil moisture conditions in the field. Interpolated water content value had a fairly strong relationship with the soil water content and had the highest suitability, so the interpolation approach can be recommended for mapping soil water content in an oil palm plantation area.
PEMANFAATAN ABU TERBANG BATUBARA UNTUK MENINGKATKAN KETERSEDIAAN P, SERTA PENGARUHNYA TERHADAP PERTUMBUHAN TANAMAN KANGKUNG DARAT (Ipomoea reptans Poir)
Authors: Jayengswasono Panggah , Wicaksono Karuniawan Sigit
Published: June 2022

Cultivation in sandy soils encounters many obstacles due to the nature of the soil, which has a poor ability to hold water and nutrients. In order to increase plant yield, it is necessary to add soil amendments that can improve the properties of sandy soil. The purpose of this study was to elucidate the impact of giving coal fly ash as a soil amendment on the chemical properties of soil and plants, as well as plant growth and production. The study was conducted in a greenhouse with different doses of coal fly ash applied to the growing media. The results showed that the higher dose of coal fly ash could increase the total P content (210-310%), P-available (127%), and soil Pb content (28%) compared to the control. Meanwhile, the high dose of coal fly ash can harm the growth and production of water spinach.