bluuebunny/crossref_metadata_2025 huggingface dataset:
Exogenous Application of Proline and L-Cysteine Alleviates Internal Browning and Maintains Eating Quality of Cold Stored Flat ‘Maleki’ Peach Fruits
Authors: Gohari Gholamreza , Molaei Sanaz , Kheiry Azizollah , Ghafouri Mahshid , Razavi Farhang , Lorenzo Jose M. , Juárez-Maldonado Antonio
Published: November 2021

The postharvest life of flat peach fruit is limited by the appearance of chilling injury symptoms, especially internal browning. In this study, impacts of the exogenous application of proline (0, 5, 10, and 15 mM) and L-cysteine (0, 0.2, 0.4 and 0.6%) on attenuating chilling injury of flat peach fruit were evaluated all over the cold storage. The results demonstrated that the fruits treated with 15 mM proline and 0.4 % L-cysteine showed lower levels of internal browning and these treatments prevented the excess enhancement of total soluble solids (TSS), the decline of titratable acidity (TA) content and the loss of fruit firmness during storage time. A lower accumulation of hydrogen peroxide (H2O2), malondialdehyde (MDA), electrolyte leakage, and higher activity of antioxidant enzymes, along with higher ascorbic acid content and antioxidant capacity, were observed in treated fruits. Treated fruits also showed higher activity of phenylalanine ammonia lyase (PAL) and conversely lower activity of polyphenol oxidase (PPO), which led to a higher accumulation of total phenols and flavonoids. Moreover, a higher accumulation of endogenous proline was observed in 15 mM proline treated fruits. Eventually, according to our results, the exogenous administration of proline and L-cysteine as safe, natural and environmentally friendly treatments, preserved the nutritional quality of flat peach fruits during long-term cold storage.
A SWOT Analysis of the Guidelines on Prevention of HIV/AIDS in Japan in the Context of COVID-19
Authors: Shimizu Kazuki
Published: November 2021

In January 2018, the Minister of Health, Labour and Welfare, Japan, released an amended Guideline on the Prevention of Specified Infectious Diseases on Acquired Immunodeficiency Syndrome (AIDS) to propose measures to control the human immunodeficiency virus (HIV)/AIDS. Content analysis was performed to examine the strengths, weaknesses, opportunities, and threats of the guidelines in the context of the ongoing COVID-19 pandemic, thus aiming to promote discussions on the guideline itself and the national HIV/AIDS strategy in Japan in the years ahead. The strengths included the incorporation of the latest scientific advancements, clarification of high-risk populations, an alignment with measures against sexually transmitted diseases (STDs), and willingness towards international cooperation in the Asia-Pacific region. The weaknesses that were exposed included a lack of explicit targets for controlling and containing HIV/AIDS, insufficient descriptions about pre-exposure prophylaxis (PrEP), and aggregated discussions on HIV/AIDS among foreign residents. Although several opportunities for re-energizing the discussions around HIV/AIDS were recognized, insufficient political will and funding, along with the emergence of the ongoing COVID-19 pandemic, could operate as threats. Addressing barriers that were recognized before 2019 and exposed due to the COVID-19 pandemic, and tackling underlying health inequalities through the concept of social determinants of health will be critical.
Does Coal Mining Have Effects on Land Use Changes in a Coal Resource-Based City? Evidence from Huaibei City on the North China Plain
Authors: Guan Jing , Yu Peng
Published: November 2021

Continuous coal mining results in dramatic regional land use change, and significantly influences the sustainable development of coal resource-based cities. Present studies pay little attention to the characteristics and regularities of land use change in coal resource-based cities, caused by underground coal mining in high groundwater areas. Based on the Landsat remote sensing images of 1999, 2000, 2010, and 2018 of Huaibei City, a typical coal resource-based city of a high ground water area on the North China Plain, this paper applies the dynamic degree and transition matrix of land use to analyze the land use change characteristics, and identify the regularity between land use type and coal mining production in this coal resource-based city. Results show that the land use change in the research area presents an overall characteristic of a constant increase in water area, urban construction land, and rural settlement land, and a continuous decrease in cultivated land. Cultivated land is converted into a water area, urban construction land, and rural settlement land, and rural settlement land and cultivated land are converted bidirectionally. The land use change in this coal resource-based city demonstrates significant reliance on coal resources, and coal mining is significantly related to the area of cultivated land, water area, and rural settlement land, which demonstrates that continuous large-scale coal mining results in damage to cultivated land, a decrease in rural settlement land, and an increase in water area. The research result contributes to the sustainable land use of coal resource-based cities.
How Do Chinese National Scenic Areas Affect Tourism Economic Development? The Moderating Effect of Time-Limited Rectification
Authors: Qu Yongcuomu , Zhang Ziqiong , Feng Yanchao , Cui Xiaorong
Published: November 2021

Based on panel data on 124 prefecture-level and above cities from 2003 to 2018, this study investigated the impact of CNSAs on tourism economic development and the moderating effect of time-limited rectification by comprehensively using the quasi-DID model, the static spatial Durbin model, and the dynamic spatial Durbin model. The results showed that the impact of CNSAs on tourism economic development has a heterogeneous characteristic in terms of tourists and revenue. In addition, the spatial spillover effect and the path dependence have effectively promoted tourism economic development. Furthermore, the effectiveness of time-limited rectification has been proved in this study, while the “beggar-thy-neighbor” effect has, to some extent, weakened the promotional effect of CNSAs on tourism economic development, especially in terms of international tourists and international tourism revenue. Finally, relevant policy implications for the superior department in charge, local governments, and the management department of CNSAs are outlined to provide a practical reference for promoting the high-quality development of the tourism economy in China.
The Prevalence of Mental Distress and Social Support among University Students in Jordan: A Cross-Sectional Study
Authors: Abuhamdah Sawsan M. A. , Naser Abdallah Y. , Abdelwahab Ghada Mohammad , AlQatawneh Ahmad
Published: November 2021

Objectives: To examine the prevalence of mental distress among university students in Jordan. Methods: An online cross-sectional study using a self-administered questionnaire was conducted between 12th of June and the 4th of August 2021 in Jordan to measure student mental stress using Self-Reporting Questionnaire-20 (SRQ-20). Results: A total of 1063 university students participated in the study. One-third of the participating students reported that they had a history of COVID-19 infection. More than half of the participating university students (65.7%) were found to have mental distress (measured symptomatically by the SRQ-20 with a score of eight or more). The average mental distress score was 9.8 (SD: 5.5) out of 20. Female students, students from non-medical colleges, students in their last years of study, students with chronic diseases and those with low income were associated with high levels of mental distress (p < 0.05). With regards to social support, a moderate level of social support was received from three sources: persons considered as significant others, family members, and friends. The average social support score for the participating university students was 41.9 (SD: 10.3) out of 60 (equivalent to 69.8%). Conclusions: Mental distress is prevalent among university students in Jordan. There is a need for evidence-based governmental strategies and interventions that provide social support at universities such as self-help measures and professional mental health services as part of student health services that would be helpful to reduce the burden of mental distress of students and promote the mission of the integration of mental health in all university policies.
A Study on the Mechanism and Strategy of Cross-Regional Emergency Cooperation for Natural Disasters in China—Based on the Perspective of Evolutionary Game Theory
Authors: Liu Jida , Guo Yanan , An Shi , Lian Chenxi
Published: November 2021

Natural disasters have obvious cross-regional and compound characteristics. Cross-regional emergency cooperation for natural disasters deepens the diversification of coordination relations and the complexity of interaction modes among emergency response organizations, including horizontal and vertical organizational interactions. In order to clarify the cooperation mechanism of emergency organizations during cross-regional emergency cooperation for natural disasters and to explore the key factors that affect the cooperative relationships of emergency organizations, in this study, a game model is constructed based on evolutionary game theory, which is composed of local, neighboring, and central governments. Then, the stability of the emergency game strategy is analyzed. On this basis, a numerical simulation is used to simulate the dynamic evolution trajectory of the game system. The results show that there is an embedded mutual promotion mechanism that evolves towards a positive emergency strategy combination among the game subjects. The selection strategies of the game subjects show the characteristics of consistency and the following: enhanced cooperation efficiency between local and neighboring governments, emergency capital stock, and shared resources, therefore, guiding social emergency forces to actively participate in emergency operations. Strengthening the emergency dispatching strength of the central government and the effectiveness of central–local emergency dispatching, can support the performance of cross-regional emergency cooperation for natural disasters. Furthermore, the efficiency of cooperation between local and neighboring governments will be enhanced.
Lifestyle Medicine Reimbursement: A Proposal for Policy Priorities Informed by a Cross-Sectional Survey of Lifestyle Medicine Practitioners
Authors: Freeman Kelly , Grega Meagan , Friedman Susan , Patel Padmaja , Stout Ron , Campbell Thomas , Tollefson Michelle , Lianov Liana , Pauly Kaitlyn , Pollard Kathryn , Karlsen Micaela
Published: November 2021

Lifestyle medicine (LM) is a rapidly emerging clinical discipline that focuses on intensive therapeutic lifestyle changes to treat chronic disease, often producing dramatic health benefits. In spite of these well-documented benefits of LM approaches to provide evidence-based care that follows current clinical guidelines, LM practitioners have found reimbursement challenging. The objectives of this paper are to present the results of a cross-sectional survey of LM practitioners regarding lifestyle medicine reimbursement and to propose policy priorities related to the ability of practitioners to implement and achieve reimbursement for these necessary services. Results from a closed, online survey in 2019 were analyzed, with a total of n = 857 included in this analysis. Results were descriptively analyzed. This manuscript articulates policy proposals informed by the survey results. The study sample was 58% female, with median age of 51. A minority of the sample (17%) reported that all their practice was LM, while 56% reported that some of their practice was LM. A total of 55% of practitioners reported not being able to receive reimbursement for LM practice. Of those survey respondents who provided an answer to the question of what would make the practice of LM easier (n = 471), the following suggestions were offered: reimbursement overall (18%), reimbursement for more time spent with patients (17%), more support from leadership (16%), policy measures to incentivize health (13%), education in LM for practitioners (11%), LM-specific billing codes and billing knowledge along with better electronic medical record (EMR) capabilities and streamlined reporting/paperwork (11%), and reimbursement for the extended care team (10%). Proposed policy changes focus on three areas of focus: (1) support for the care process using a LM approach, (2) reimbursement emphasizing outcomes of health, patient experience, and delivering person-centered care, and (3) incentivizing treatment that produces disease remission/reversal. Rectifying reimbursement barriers to lifestyle medicine practice will require a sustained effort from health systems and policy makers. The urgency of this transition towards lifestyle medicine interventions to effectively address the epidemic of chronic diseases in a way that can significantly improve outcomes is being hindered by current reimbursement policies and models.
Individual and Interpersonal Factors Associated with the Incidence, Persistence, and Remission of Internet Gaming Disorders Symptoms in an Adolescents Sample
Authors: Marrero Rosario J. , Fumero Ascensión , Voltes Dolores , González Manuel , Peñate Wenceslao
Published: November 2021

Video game playing behavior has serious consequences for adolescents on a personal, family, social, and academic level. This research aimed to examine risk and protective factors involving incidence, persistence, and remission of gaming disorders symptoms (IGDs) in Spanish adolescents after nine months of follow-up. Data were drawn from self-administered questionnaires completed on two occasions: at the beginning (T1) and end of the academic year (T2). A total of 950 adolescents aged from 11 to 20 years (M = 14, SD = 1.52, 48.5% female) completed the questionnaire at T1, while 550 adolescents aged from 11 to 18 years (M = 13.43, SD = 1.23, 48.9% female) took part in the follow-up study (T2). The incidence, persistence, and remission rates were 6%, 2.7%, and 4.2%, respectively. Significant relationships with IGDs were found between the male gender and studying at a private school in T1 and T2. The findings show that the time spent playing video games during T1 was positively associated with IGDs in T1 and T2. The incidence of IGDs was associated with emotional problems and low family affection. The persistence of IGDs was linked to higher motor impulsivity, agreeableness, and lower family resolve. Remission was related to a decrease in anxiety and hostility as well as an increase in the emotional stability of adolescents. These findings imply that emotional well-being and family adjustment could be relevant for the effective management of gaming behaviors.
Association of Instrumental Activities of Daily Living, Physical Function, and Mental Health among Older Returnees after the Fukushima Daiichi Nuclear Power Station Accident
Authors: Moriyama Nobuaki , Nishikawa Yoshitaka , Hoshi Wataru , Kuga Tomomi , Iwasa Hajime , Murayama Tomoo , Itagaki Tatsuya , Saito Yuta , Yasumura Seiji
Published: November 2021

The 2011 Great East Japan Earthquake and consequent Fukushima Daiichi Nuclear Power Station accident caused a large-scale evacuation, generating various health issues. Although residents gradually returned, their independence of daily living and associated factors remain unknown. This study examines the hypothesis that physical and mental status are associated with the instrumental activities of daily living (IADL) of older returnees (65 years and above) after the disaster. Older returnees to Kawauchi Village, Fukushima Prefecture, located 20–30 km southwest of the power plants, were recruited. IADL was assessed using the Japan Science and Technology Agency Index of Competence, physical function via the 30-s chair stand test, and mental health via the Japanese version of the World Health Organization Five Well-Being Index. To examine the association of IADL and possible factors, a t-test or Pearson’s product-moment correlation coefficient was used, stratified by sex. The data of 29 participants (75.5 ± 7.4 years, 19 female) were analyzed. Physical function was associated with IADL in females. Mental health was associated with IADL in males and females. Taking measures to strengthen physical function in females, as well as to improve mental health in both sexes, for enhancing IADL ability could be beneficial.
Health Care Services Utilization of Persons with Direct, Indirect and without Migration Background in Germany: A Longitudinal Study Based on the German Socio-Economic Panel (SOEP)
Authors: Grochtdreis Thomas , König Hans-Helmut , Dams Judith
Published: November 2021

There is ambiguous evidence with regard to the inequalities in health care services utilization (HCSU) among migrants and non-migrants in Germany. The aim of this study was to analyze the utilization of doctors and hospitalization of persons with direct and indirect migration background as well as those without in Germany. This study was based on data of the German Socio-Economic Panel using the adult sample of the years 2013 to 2019. HCSU was measured by self-reported utilization of doctors and hospitalization. Associations between HCSU and migration background were examined using multilevel mixed-effects logistic regression and zero-truncated multilevel mixed-effects generalized linear models. The odds ratios of utilization of doctors and hospitalization for persons with direct migration background compared with persons without migration background were 0.73 (p < 0.001) and 0.79 (p = 0.002), respectively. A direct migration background was associated with a 6% lower number of doctoral visits within three months compared with no migration background (p = 0.023). Persons with direct migration background still have a lower HCSU than persons without migration background in Germany. Access to health care needs to be ensured and health policy-makers are called upon to keep focus on the issue of inequalities in HCSU between migrants and non-migrants in Germany.
Influence of Preventive Tooth Extractions on Quality of Life in Patients with Antiresorptive Intake—A Prospective Longitudinal Study
Authors: Rückschloß Thomas , Moratin Julius , Zittel Sven , Pilz Maximilian , Roser Christoph , Engel Michael , Freudlsperger Christian , Hoffmann Jürgen , Ristow Oliver
Published: November 2021

Background: To find out whether preventive tooth extractions in patients on antiresorptive therapy have a direct impact on the patients’ overall quality of life (QoL); Methods: QoL using the five-level version of the EuroQol Group’s EQ-5D instrument (EQ-5D-5L) was longitudinally assessed in N = 114 prospectively enrolled patients with indication of preventive tooth extraction over a period of 12 months. Patients were stratified as high-risk (malignant disease with bone metastasis or multiple myeloma, with monthly high-dose antiresorptive therapy delivered intravenously [bisphosphonate] or subcutaneously [denosumab]) and low-risk/osteoporosis patients (weekly low-dose antiresorptive therapy administered orally [bisphosphonate] or half-yearly subcutaneously [denosumab]). The measurement time points were 4 weeks preoperatively (T0), 2 months (T1) and 1 year postoperatively (T2), respectively. Results: EQ-5D-5L index scores fell in a range from −0.21 to 1.00 in the low-risk group to 0.15 to 1.00 in the high-risk group. The t-test comparing the baseline index scores of both groups showed EQ-5D-5L index score in the low-risk group (0.708 ± 0.292) to be significantly smaller (p = 0.037) than in the high-risk group (0.807 ± 0.19). ANCOVA showed no significant differences in EQ-5D-5L index scores between the groups at T1 and T2. Conclusions: Preventive tooth extractions in patients undergoing antiresorptive treatment have no negative effect on QoL. Therefore, if indicated, preventive tooth extraction should not be omitted. Patient-oriented outcome measures are important to obtain a good risk–benefit balance for patient-specific treatment.
Factors Related to Women’s Psychological Distress during the COVID-19 Pandemic: Evidence from a Two-Wave Longitudinal Study
Authors: Di Blasi Maria , Albano Gaia , Bassi Giulia , Mancinelli Elisa , Giordano Cecilia , Mazzeschi Claudia , Pazzagli Chiara , Salcuni Silvia , Lo Coco Gianluca , Gelo Omar Carlo Gioacchino , Lagetto Gloria , Freda Maria Francesca , Esposito Giovanna , Caci Barbara , Merenda Aluette , Salerno Laura
Published: November 2021

Background. A growing body of research has highlighted the negative effects of the COVID-19 pandemic on women’s mental health. Previous studies showed that women have higher levels of depression, anxiety and PTSD, and worse psychological adjustment than men, which also persisted after the earlier phase of the pandemic. This study aimed to evaluate changes in women’s psychological distress during the pandemic and to evaluate the factors that have a more significant impact in predicting women’s psychological distress. Methods. This two-wave longitudinal study (T1 = Italian first lockdown, and T2 = second phase, when the restrictive measures were eased) involved 893 women (Mage = 36.45, SD = 14.48). Participants provided demographic and health data as well as measures of psychological distress, emotion regulation processes, and ability to tolerate uncertainty. Results. No significant changes were found in women’s psychological distress between T1 and T2, i.e., during and after the first lockdown. Lower social stability status and higher maladaptive emotional coping predicted high psychological distress. Conclusions. Results showed that modifiable psychological variables play a central role in predicting distress and indicated that emotion regulation interventions might be helpful in increasing psychological resilience and mitigating the adverse impacts of the COVID-19 pandemic within the female population.
Homelessness and Public Health: A Focus on Strategies and Solutions
Authors: Sleet David A. , Francescutti Louis Hugo
Published: November 2021

On any given night, hundreds of thousands of people are homeless in the United States and Canada [...]
Meta-Analysis of the Effect of Yoga Practice on Physical Fitness in the Elderly
Authors: Shin Sohee
Published: November 2021

The purpose of this study was to meta-analyze the effects of yoga intervention on physical fitness in the elderly. The following databases were systematically searched in 25 March 2021: Cochrane, PubMed and Embase. A total of 656 papers was identified through key word combinations, finally, 12 studies were included in the meta-analysis. The main conclusions are as follows. First, yoga practice showed moderately positive effects on muscle strength, balance, mobility, and lower body flexibility, but had no significant effect on cardiorespiratory endurance and upper body flexibility. Second, sub-group analysis showed that subjects in their 60s and 70s and yoga practice for 9–12 weeks had a large positive effect on physical fitness. Yoga is a multimodal activity that improves muscle strength, balance, and flexibility in the elderly, and physical activity policies should continue to promote yoga as an activity that enhances physical and mental wellbeing in this population.
Factors Associated with Smartphone Addiction Tendency in Korean Adolescents
Authors: Kim Ji-Hye
Published: November 2021

This study aims to identify the factors associated with smartphone addiction tendency in Korean adolescents. A convenience sample of 502 students from four middle schools participated in the survey for the assessment of demographic, personal factors (resilience and academic stress), environmental factors (parental support, teacher support, friend support, and bullying victimization), as well as smartphone addiction tendency. Smartphone addiction tendency was determined based on the Smartphone Addiction Proneness Scale for Youth (SAPS) criteria developed by Kim et al. The collected data were analyzed using descriptive statistics, chi-squared test, t-test, Pearson’s correlation coefficients, and hierarchical logistic regression. Among the adolescents, 17.9% were in the smartphone addiction tendency group. The factors associated with smartphone addiction tendency were subjective economic level, academic stress, parental support, and bullying victimization. Based on the findings of this study, it is considered necessary to approach smartphone addiction management considering personal factors as well as environmental factors.
The Validity and Reliability of the Malay Version of the Cyberbullying Scale among Secondary School Adolescents in Malaysia
Authors: Saman Zaitun Mohd , Siti-Azrin Ab Hamid , Othman Azizah , Kueh Yee Cheng
Published: November 2021

The effect of cyberbullying among adolescents in Malaysia is not much studied. The Cyberbullying Scale (CBS) has been validated to be used among English speaking adolescents to measure cyberbullying but not in Malay language. Therefore, its validity should be established before use in the Malaysian context. Thus, the study aimed to evaluate the validity and reliability of the Malay version of the CBS (CBS-M) among secondary school students. The study was cross-sectional and involved a self-administered questionnaire with 16 items from CBS-M, and 21 items from the Depression, Anxiety, and Stress Scale (DASS-21). Participants were recruited using a multi-stage sampling method. The validity of the CBS-M was tested in two phases, namely, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA). Spearman’s correlation was used to examine the strength of the relationship between the CBS and subscales from DASS-21 to further support the validity of CBS-M. A total of 401 respondents from Muar, Johor, participated. The mean age was 14.6 years (SD = 1.25). EFA results indicated a one-factor model of CBS-M with a total variance extracted of 33.9%. Internal consistency measured by Cronbach’s alpha reached 0.87. The model was then tested using CFA. The initial model did not fit the data well. Thus, several model re-specifications were conducted on the initial model. The final measurement model of CBS-M fit the data well with acceptable fit indices (CFI = 0.946, TLI = 0.932, SRMR = 0.055, RMSEA = 0.049). The composite reliability for CBS-M was satisfactory with a value of 0.832. The CBS-M questionnaire is a valid and reliable tool for measuring cyberbullying among young adolescents in Malaysia.
Parameters Influencing the Emission of Ultrafine Particles during 3D Printing
Authors: Chýlek Radomír , Kudela Libor , Pospíšil Jiří , Šnajdárek Ladislav
Published: November 2021

This paper presents a complex and extensive experimental evaluation of fine particle emissions released by an FDM 3D printer for four of the most common printing materials (ABS, PLA, PET-G, and TPU). These thermoplastic filaments were examined at three printing temperatures within their recommended range. In addition, these measurements were extended using various types of printing nozzles, which influenced the emissions considerably. This research is based on more than a hundred individual measurements for which a standardized printing method was developed. The study presents information about differences between particular printing conditions in terms of the amount of fine particles emitted as well as the particle size distributions during printing periods. This expands existing knowledge about the emission of ultrafine particles during 3D printing, and it can help reduce the emissions of these devices to achieve cleaner and safer 3D printer operations.
Self-Fetal Wellbeing Monitoring and Ante-Natal Care during the COVID-19 Pandemic: A Qualitative Descriptive Study among Pregnant Women in Indonesia
Authors: Widiasih Restuning , Hidayat Dini , Zakaria Hasballah , Utama Dody Qori , Komariah Maria , Maryam Nenden Nur Asriyani , Arifin Hidayat , Agustina Habsyah Saparidah , Nelson Katherine
Published: November 2021

Pregnant women are expected to have a high level of awareness when it comes to checking their fetal health and ensuring their welfare. This study explored the experiences of pregnant women in Indonesia who were monitoring their fetal wellbeing during the COVID-19 pandemic. A qualitativedescriptive study design with a constructivist paradigm was used. Twenty-two pregnant women were recruited and participated in a semi-structured interview. Analysis of the transcribed interviews used a content, thematic and comparative process. Three themes emerged from the analysis: feelingsand responses, changes to the ante natal care service during the COVID-19 pandemic, and the fetal wellbeing monitoring, tools, and methods used. Advice on how pregnant women should conduct fetal wellbeing monitoring during COVID-19 is urgently needed. The results of this study indicate there is a need for interventions to help pregnant women carry out self-fetal wellbeing monitoring in times where they have fewer contacts with health professionals such as during the COVID-19 pandemic.
Moving Past the One-Size-Fits-All Education-Training Model of Police Academies to the Self-Prescribed Individualized Exercise Prescription Model
Authors: Papadakis Zacharias , Stamatis Andreas , Kukic Filip , Koropanovski Nenad
Published: November 2021

Law enforcement agencies generally employ the “one-size-fits-all” education-training model. Its effectiveness compared to alternative training models has been under scrutiny. Physical fitness scores of Serbian male (n = 98) and female (n = 79) police cadets during their yearly evaluation were compared. Cadets trained for the first 3 years with the “one-size-fits-all” model. In the fourth year, they self-prescribed an individualized exercise program based on the obtained curriculum knowledge. A two-way MANOVA revealed a significant effect of academic years on combined variables (p < 0.001) and significant differences between academic years for deadlift, half squat, standing long jump, sit-ups and 12-min Cooper test time (p < 0.001). Sex also had a significant main effect on combined variables (p < 0.001) with males outscoring females on all of the fitness assessments. For pull-ups, there was a significant year * sex interaction (p = 0.01) with the third year to be pivotal for female and male performance, respectively. In conclusion, the use of a “one-size-fits-all” model, presented differences in physical fitness scores between the years one to three, pointing to its questionable effectiveness. On the contrary, the self-prescribed individualized exercise program of the fourth year elicited greater fitness scores, indicating the need to evaluate the applicability of such a training model more.
Higher Risk of Gastric Helicobacter pylori Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
Authors: Li Xin , Chaouhan Hitesh Singh , Li Ching-Hao , Yu Tung-Min , Wang I-Kuan , Lin Cheng-Li , Li Chi-Yuan , Sun Kuo-Ting
Published: November 2021

Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gastric Helicobacter pylori (Hp) infection; however, evidence that showing the association between periodontitis and the risk of gastric Hp infection is less clear. We conducted a large-scale, population-based study in Taiwan with a 13-year follow-up period to evaluate the risk of gastric Hp in a periodontitis patient cohort. To conduct this study, we used epidemiological data from the Taiwanese Longitudinal National Health Insurance Research Database (NHIRD) from 2000 to 2013. We selected 134,474 participants (64,868 males and 69,606 females with a minimum age of 20 years), with and without periodontitis, and matched patient cohort groups for age, sex, index year, and co-morbidities. The Cox proportional hazards regression model was used to examine the risk of gastric Hp infection in patients with periodontitis. Patients with periodontitis exhibited a higher risk of developing gastric Hp infection compared to those individuals/groups without periodontitis (1.35 vs. 0.87 per 1000 person-years, adjusted the hazards ratio (aHR 1.52), and 95% confidence intervals (CIs) 1.38–1.67, p < 0.001). The risk of gastric Hp infection persisted even after stratifying by age (aHR = 1.96 (1.79–2.13) for 50–64 years and 1.70 (1.49–1.94) for ≥65 years), gender (aHR = 1.20 (1.11–1.29) for men), and presence of comorbidities of hypertension (aHR = 1.24 (1.11–1.38)), hyperlipidemia (aHR = 1.28 (1.14–1.42)), COPD (aHR = 1.45 (1.31–1.61)), CLD (aHR = 1.62 (1.47–1.77)) and CKD (aHR = 1.44 (1.04–1.99)). Overall, our findings showed that periodontitis patients have a greater risk for gastric Hp than individuals without periodontitis. Clinicians should perform regular good oral hygiene practices, along with newer treatments, for patients with periodontitis, especially those at higher risk of gastric Hp infection.
Sleep Disorders in Cancer—A Systematic Review
Authors: Büttner-Teleagă Antje , Kim Youn-Tae , Osel Tiziana , Richter Kneginja
Published: November 2021

Introduction: Sleep disorders, especially insomnia, are very common in different kinds of cancers, but their prevalence and incidence are not well-known. Disturbed sleep in cancer is caused by different reasons and usually appears as a comorbid disorder to different somatic and psychiatric diagnoses, psychological disturbances and treatment methods. There can be many different predictors for sleep disturbances in these vulnerable groups, such as pre-existing sleep disorders, caused by the mental status in cancer or as side effect of the cancer treatment. Methods: A systematic literature review of 8073 studies was conducted on the topic of sleep and sleep disorders in cancer patients. The articles were identified though PubMed, PsycInfo and Web of Knowledge, and a total number of 89 publications were qualified for analysis. Results: The identified eighty-nine studies were analyzed on the topic of sleep and sleep disorders in cancer, twenty-six studies on sleep and fatigue in cancer and sixty-one studies on the topic of sleep disorders in cancer. The prevalence of sleep disturbences and/or sleep disorders in cancer was up to 95%. Discussion: Sleep disturbances and sleep disorders (such as insomnia, OSAS, narcolepsy and RLS; REM-SBD) in cancer patients can be associated with different conditions. Side effects of cancer treatment and cancer-related psychological dysfunctions can be instigated by sleep disturbances and sleep disorders in these patients, especially insomnia and OSAS are common. An evidence-based treatment is necessary for concomitant mental and/or physical states.
School Interventions for Bullying–Cyberbullying Prevention in Adolescents: Insights from the UPRIGHT and CREEP Projects
Authors: Gabrielli Silvia , Rizzi Silvia , Carbone Sara , Piras Enrico Maria
Published: November 2021

Background: Several challenges and emotional demands characterize adolescence, affecting the mental well-being of youths. Among these, bullying and cyberbullying are recognized nowadays as a major social problem, affecting more than one-third of adolescents, with extensive negative consequences for the victims involved, such as lower self-esteem, increased loneliness, depression, and anxiety. School programs and interventions that foster resilience, coping, and well-being are particularly important during adolescence as protective and preventive factors against the consequences of (cyber)bullying. The paper presents two recent co-designed interventions for (cyber)bullying prevention deployed in Europe, targeting early adolescents and their school communities. Methods: The UPRIGHT project developed an evidence-based, whole-school intervention to train resilience as a protective factor to promote mental well-being in adolescents, in a cross-national perspective. The CREEP project designed and implemented digital interventions to support schools in (i) early detection of cyberbullying events on social media and (ii) coaching adolescents (victims, bullies, bystanders) on how to cope with (cyber)bullying behaviors. Results: The main challenges and insights collected during the design and implementation of both interventions are discussed to inform future research and practice. Conclusion: The feasibility and acceptance of prevention programs are key to the reducing risk of (cyber)bullying and improving the psychological well-being of early adolescents.
Human Papillomavirus Prevalence in Urine Samples of Asymptomatic Male Sexual Partners of Women with Sexually Transmitted Diseases
Authors: Jin Hyunwoo , Kim Dong Hyeok , Lee Kyung Eun
Published: November 2021

Human papillomavirus (HPV) infection in males is associated with various cancers, including cervical cancer in women and penile and bladder cancers in men. However, there is limited research on the prevalence and prevention of male HPV infection. Moreover, a rapid test that can prevent the increase in HPV infection is needed. In this study, the prevalence of sexually transmitted pathogen (STP) and HPV infection was analyzed using real-time polymerase chain reaction assay in random urine samples collected from asymptomatic male sexual partners of women with sexually transmitted diseases. Among 130 men, 65 (50.0%) had STP and 12 (9.23%) had HPV infection. There was no association between STP and HPV infection. Among 12 cases of HPV infection, three were HPV-16 single infections, six were multiple infections, including HPV-16, and three of other high-risk HPV infections. Our results suggest the need for STP testing, including HPV testing, in sexual partners of high-risk women with sexually transmitted diseases, even in men without clinical symptoms (asymptomatic). Further research should be conducted by diversifying urine samples. We report the most convenient method for HPV detection, and it is expected to be widely applied to prevent sexually transmitted diseases in men and women.
Boredom Intervention Training Phase I: Increasing Boredom Knowledge through a Psychoeducational Video
Authors: Parker Patti C. , Tze Virginia M. C. , Daniels Lia M. , Sukovieff Alyse
Published: November 2021

Boredom is a salient emotion experienced in postsecondary settings, and evidence reveals that it can negatively impact academic achievement and motivation. Drawing from the control-value theory (CVT) of achievement emotions (Pekrun, 2006) and the component process model of emotions (CPM; Scherer, 1984), our study examines the first phase of a multi-sequenced online boredom intervention training (BIT) program. The goal of Phase I of BIT was to increase university students’ (N = 85) knowledge about boredom as a scholarly construct. Students completed four components of the Phase I BIT session, including: (a) a baseline survey and knowledge quiz, (b) a psychoeducational video, (c) a consolidation exercise, and (d) a follow-up knowledge quiz. We employed a repeated measures analysis to measure changes in knowledge after students watched the psychoeducational boredom video. Our findings reveal that students became more knowledgeable about boredom, learned something novel, and were interested in the intervention. The results are discussed in terms of the implications for research, theory, and practice.
The Influence of Discrepancies between Parents’ Educational Aspirations and Children’s Educational Expectations on Depressive Symptoms of Left-Behind Children in Rural China: The Mediating Role of Self-Efficacy
Authors: Man Xiaoou , Liu Jiatong , Bai Yutong
Published: November 2021

Although long-term separation has made discrepancies between parents’ educational aspirations and children’s own educational expectations among families with left-behind children (LBC), limited researches on the influence of these discrepancies on children’s mental health are carried out at present. Based on China Family Panel Studies (CFPS) conducted in 2018, we selected 875 LBC aged 9~15 as the sample, explored the influence of the direction and degree of these discrepancies on LBC’s depressive symptoms by hierarchical regression, and examined the mediating role of children’s academic self-efficacy and mediation effect pathway with Baron and Kenny method and Bootstrap mediation analysis methods. Results showed that LBC’s mental health was worse when parents’ educational aspirations were higher than their children’s educational expectations, compared to that without discrepancies. The degree of such discrepancies was negatively associated with LBC’s mental health. In the relationship between the direction of discrepancies and LBC’s depressive symptoms, academic self-efficacy played a mediating role partially. In addition, the study indicated that mothers played a significant role in the development of LBC’s mental health. These findings also provided critical evidence for the intervention practice of LBC’s mental health.
Effects of the Healing Beats Program among University Students after Exposure to a Source of Psychological Stress: A Randomized Control Trial
Authors: Song Jiah , Kim Wonjong , Bae Iklyul
Published: November 2021

This study is a randomized pre- and post-controlled trial to determine the effects of the Healing Beats program on anxiety, autonomic nervous balance, Bispectral (BIS) index, and heart rate among university students after exposure to a source of mental stress. Data were collected from candidates who volunteered from November 2018 to May 2019 in response to recruitment announcements. The analysis was performed using data of 99 participants in three groups: 32 in an experimental group, 35 in a placebo group, and 32 in a control group. The experimental group who received treatment via the Healing Beats program exhibited a significant effect on calming anxiety, autonomic nervous balance, BIS index, and heart rate, compared with the placebo group and the control group. The group interaction also showed a significant difference. The Healing Beats program can be used as an effective intervention for sedation in clinical situations or calmness in stressful situations in everyday life. Specifically, the Healing Beats program could serve as basic data for nursing interventions, according to the stability effect in stressful situations; it can also be applied to effective nursing practice as an initial study to confirm theoretical and practical indicators.
Assessment of the Strength Parameters of the Quadriceps Femoris Muscles in Polish University Students after a 3-Week Program of Neuromuscular Electrical Stimulation Using the RSQ1 Method
Authors: Rywacka Aleksandra , Stefańska Małgorzata , Dziuba-Słonina Alicja
Published: November 2021

A rehabilitative program for patients who lose strength and muscle mass along with the ability to perform intensive exercises is lacking. We developed a 3-week training program based on neuromuscular electrical stimulation (NMES) using a RSQ1 device (modulated current resulting from the overlapping of two-component currents) for RSQ1 electrostimulation to improve strength parameters of the quadricep femoris muscles and compare its effectiveness to isometric training. Nineteen university students were randomly divided into the NMES group (10 sessions) and the control group who trained. We measured the circumference of the thigh, as well as peak torques of the flexor and extensor muscles before and after the start and after the end of the training program. Both tested training programs gave similar results. Differences between measured parameters were not significant except for differences in the peak torques of the knee flexors (9.9% for left limb; p = 0.2135 vs. 7.8% for rift limb; p = 0.2135) and the circumference of the left thigh—2% for both (left p = 0.5839 and right p = 0.1088). Comparable results of the tested training programs suggest that NMES is a good alternative for people who cannot perform exercises, but want to maintain or improve their physical fitness.
Affibody Functionalized Beads for the Highly Sensitive Detection of Cancer Cell-Derived Exosomes
Authors: Sayyadi Nima , Zhand Sareh , Razavi Bazaz Sajad , Warkiani Majid Ebrahimi
Published: November 2021

Exosomes belong to the class of extracellular vesicles of endocytic origin, which are regarded as a promising source of cancer biomarkers in liquid biopsy. As a result, an accurate, sensitive, and specific quantification of these nano-sized particles is of significant importance. Affinity-based approaches are recognized as the most valuable technique for exosome isolation and characterization. Indeed, Affibody biomolecules are a type of protein scaffold engineered with small size and enjoy the features of high thermal stability, affinity, and specificity. While the utilization of antibodies, aptamers, and other biologically active substances for exosome detection has been reported widely, there are no reports describing Affibody molecules’ usage for exosome detection. In this study, for the first time, we have proposed a novel strategy of using Affibody functionalized microbeads (AffiBeads) for exosome detection with a high degree of efficiency. As a proof-of-concept, anti-EGFR-AffiBeads were fabricated and applied to capture and detect human lung A549 cancer cell-derived EGFR-positive exosomes using flow cytometry and fluorescent microscopy. Moreover, the capture efficiency of the AffiBeads were compared with its counterpart antibody. Our results showed that the Affibody probe had a detection limit of 15.6 ng exosomes per mL (~12 exosomes per AffiBead). The approach proposed in the current study can be used for sensitive detection of low expression level markers on tumor-derived exosomes, providing a basis for early-stage cancer diagnosis.
Investigating the Relationship of Genotype and Geographical Location on Volatile Composition and Sensory Profile of Celery (Apium graveolens)
Authors: Turner Lucy , Lignou Stella , Gawthrop Frances , Wagstaff Carol
Published: November 2021

Numerous varieties of celery are grown in multiple countries to maintain supply, demand and availability for all seasons; thus, there is an expectation for a consistent product in terms of taste, flavour, and overall quality. Differences in climate, agronomy and soil composition will all contribute to inconsistencies. This study investigated the volatile and sensory profile of eight celery genotypes grown in the UK (2018) and Spain (2019). Headspace analysis determined the volatile composition of eight genotypes, followed by assessment of the sensory profile using a trained panel. Significant differences in the volatile composition and sensory profile were observed; genotype and geographical location both exerted influences. Two genotypes exhibited similar aroma composition and sensory profile in both locations, making them good candidates to drive breeding programmes aimed at producing varieties that consistently display these distinctive sensory properties. Celery samples harvested in the UK exhibited a higher proportion of sesquiterpenes and phthalides, whereas samples harvested in Spain expressed a higher aldehyde and ketone content. Studying the relationship between growing environment and genotype will provide information to guide growers in how to consistently produce a high-quality crop.