bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between Bruxism and Gastroesophageal Reflux Disorder and Their Effects on Tooth Wear. A Systematic Review
Authors: Nota Alessandro , Pittari Laura , Paggi Martina , Abati Silvio , Tecco Simona
Published: February 2022

Bruxism and gastroesophageal reflux (GERD) can lead to wear of the dental tissues. Wear has a mechanical or chemical origin, and it is of extrinsic or intrinsic type. Bruxism and GERD are two etiological factors of dental wear. The intrinsic mechanical wear (abfraction) of Bruxism and intrinsic chemical wear (erosion) of GERD are both involved in sleep disorders; indeed, they could have associations and act in synergy in dental wear. The purpose of this review was to find out the possible associations between bruxism and GERD and their effects on tooth wear. The research was conducted on PubMed and the Cochrane Library using the following Keywords/Mesh Terms: Tooth wear, Bruxism, Sleep Bruxism, Sleep Disorders, or GERD. Only systematic reviews and clinical studies performed exclusively on human subjects were included in the review. Initially, the research gave more than 630 results on dental wear, bruxism and GERD and after application of the inclusion criteria irrelevant studies were excluded, and 5 studies were finally included in this review. It was possible to observe the presence of some associations between the two problems (reflux and GERD) and hypothesize negative effects on tooth wear. This research revealed the presence of an interconnection between these three problems (reflux, GERD and tooth wear) that can further act in synergy by attacking the hard dental tissues both from a chemical (reflux) and mechanical (bruxism) point of view. The dentist could play a role of “sentinel” in a multidisciplinary team, intercepting these problems early in order to treat them in the most appropriate way. PROSPERO Registration Number: CRD42021234209.
Expanding the Role of Ultrasound for the Characterization of Renal Masses
Authors: Roussel Eduard , Campi Riccardo , Amparore Daniele , Bertolo Riccardo , Carbonara Umberto , Erdem Selcuk , Ingels Alexandre , Kara Önder , Marandino Laura , Marchioni Michele , Muselaers Stijn , Pavan Nicola , Pecoraro Angela , Beuselinck Benoit , Pedrosa Ivan , Fetzer David , Albersen Maarten ,   on behalf of the European Association of Urology (EAU) Young Academic Urologists (YAU) Renal Cancer Working Group
Published: February 2022

The incidental detection of renal masses has been steadily rising. As a significant proportion of renal masses that are surgically treated are benign or indolent in nature, there is a clear need for better presurgical characterization of renal masses to minimize unnecessary harm. Ultrasound is a widely available and relatively inexpensive real-time imaging technique, and novel ultrasound-based applications can potentially aid in the non-invasive characterization of renal masses. Evidence acquisition: We performed a narrative review on novel ultrasound-based techniques that can aid in the non-invasive characterization of renal masses. Evidence synthesis: Contrast-enhanced ultrasound (CEUS) adds significant diagnostic value, particularly for cystic renal masses, by improving the characterization of fine septations and small nodules, with a sensitivity and specificity comparable to magnetic resonance imaging (MRI). Additionally, the performance of CEUS for the classification of benign versus malignant renal masses is comparable to that of computed tomography (CT) and MRI, although the imaging features of different tumor subtypes overlap significantly. Ultrasound molecular imaging with targeted contrast agents is being investigated in preclinical research as an addition to CEUS. Elastography for the assessment of tissue stiffness and micro-Doppler imaging for the improved detection of intratumoral blood flow without the need for contrast are both being investigated for the characterization of renal masses, though few studies have been conducted and validation is lacking. Conclusions: Several novel ultrasound-based techniques have been investigated for the non-invasive characterization of renal masses. CEUS has several advantages over traditional grayscale ultrasound, including the improved characterization of cystic renal masses and the potential to differentiate benign from malignant renal masses to some extent. Ultrasound molecular imaging offers promise for serial disease monitoring and the longitudinal assessment of treatment response, though this remains in the preclinical stages of development. While elastography and emerging micro-Doppler techniques have shown some encouraging applications, they are currently not ready for widespread clinical use.
The Prevalence and the Impact of Frailty in Hepato-Biliary Pancreatic Cancers: A Systematic Review and Meta-Analysis
Authors: Komici Klara , Cappuccio Micaela , Scacchi Andrea , Vaschetti Roberto , Delli Carpini Giuseppe , Picerno Vito , Avella Pasquale , Brunese Maria Chiara , Rengo Giuseppe , Guerra Germano , Bencivenga Leonardo
Published: February 2022

Background: Frailty has been associated with increased mortality among hepatobiliary pancreatic (HBP) cancer patients. Nevertheless, estimates of frailty prevalence in HBP cancers and the precise average effect regarding mortality remains uncertain. The present systematic review and meta-analysis aimed to quantify: (1) the prevalence of frailty in patients with liver and pancreatic cancers and (2) the impact of frailty on mortality in patients affected by liver and pancreatic cancers. Methods: MEDLINE/PubMed database search was conducted from inception until 1 November 2021, the pooled prevalence and relative risk (RR) estimate were calculated. Results: A total of 34,276 patients were identified and the weighted prevalence of frailty was 39%; (95% [C.I.] 23–56; I2 = 99.9%, p < 0.0001). Frailty was significantly associated with increased mortality RR 1.98 (95% [C.I.] 1.49–2.63; I2 = 75.9%, p = 0.006). Conclusions: Frailty prevalence is common among HBP cancer patients and exerts a significant negative impact on survival. These findings are characterized by significant heterogeneity and caution is warranted on their interpretation. However, stratification of patients with HBP cancer by frailty status may provide prognostic information and may inform priorities for decision-making strategy.
Relevance of Biotin Deficiency in Patients with Inflammatory Bowel Disease and Utility of Serum 3 Hydroxyisovaleryl Carnitine as a Practical Everyday Marker
Authors: Erbach Johanna , Bonn Florian , Diesner Max , Arnold Anne , Stein Jürgen , Schröder Oliver , Aksan Ayşegül
Published: February 2022

Background: Biotin, a water-soluble B vitamin, has demonstrable anti-inflammatory properties. A biotin-deficient diet induced a colitis-like phenotype in mice, alleviable by biotin substitution. Mice with dextran sulfate sodium (DSS)-induced colitis showed biotin deficiency and diminished levels of sodium-dependent multivitamin transporter, a protein involved in biotin absorption. Biotin substitution induced remission by reducing activation of NF-κB, a transcription factor involved in intestinal permeability and inflammatory bowel disease (IBD). We investigated for the first time a possible clinical role of biotin status in IBD. Methods: In a comparative, retrospective, cross-sectional study, serum samples of 138 patients with IBD (67 female; 72 Crohn’s disease (CD), 66 ulcerative colitis (UC)) aged 18–65 years and with a mean age (±SD) of 42.5 ± 14.3 years as well as 80 healthy blood donors (40 female; 40.0 ± 10.0 years; range 20–60 years) were analyzed. Inflammation was defined as hsCRP ≥5 mg/L, and to determine biotin status, serum 3-hydroxyisovaleryl carnitine (3HIVc) levels were measured by LC-MS/MS. Results: A total of 138 patients with IBD (67f; 72CD/66 UC; 42.5 ± 14.3 years) were enrolled: 83/138 had inflammation. Mean serum 3HIVc levels were significantly higher in IBD patients but unaffected by inflammation. Biotin deficiency (95th percentile of controls: >30 nmol/L 3HIVc) was significantly more common in IBD patients versus controls. Conclusion: High serum 3HIVc levels and biotin deficiency were associated with IBD but not inflammatory activity or disease type. Our findings suggest biotin may play a role as cause or effect in IBD pathogenesis. Routine assessment and supplementation of biotin may ameliorate IBD and support intestinal integrity.
Use of Thromboelastography and Rotational Thromboelastometry in Otolaryngology: A Narrative Review
Authors: Marsee Mathew K. , Shariff Faisal S. , Wiarda Grant , Watson Patrick J. , Sualeh Ali H. , Brenner Toby J. , McCoy Max L. , Al-Fadhl Hamid D. , Jones Alexander J. , Davis Patrick K. , Zimmer David , Folsom Craig
Published: February 2022

In the field of otolaryngology—head and neck surgery (ENT), coagulopathies present unique diagnostic and therapeutic challenges. In both hyper- and hypocoagulable patients, management of coagulopathies requires intricate attention to the nature of hemostatic competence. Common coagulation tests (CCTs) offer only a snapshot of hemostatic competence and do not provide a clear insight into the patient’s real-time hemostatic condition. Viscoelastic tests (VETs) offer a holistic and concurrent picture of the coagulation process. Although VETs have found prominent utilization in hepatic transplants, obstetrics, and emergent surgical settings, they have not been fully adopted in the realm of otolaryngology. The objective of this manuscript is to provide an overview of the literature evaluating the current utilization and possible future uses of VETs in the field of otolaryngology. The authors performed a comprehensive literature search of the utilization of VETs in otolaryngology and identified applicable studies that included descriptions of viscoelastic testing. Twenty-five studies were identified in this search, spanning topics from head and neck oncology, microvascular free flap reconstruction, obstructive sleep apnea, adenotonsillectomy, facial trauma, and epistaxis. The applicability of VETs has been demonstrated in head and neck oncology and microvascular free flap management, although their pervasiveness in practice is limited. Underutilization of VETs in the field of otolaryngology may be due to a lack of familiarity of the tests amongst practitioners. Instead, most otolaryngologists continue to rely on CCTs, including PT, PTT, INR, CBC, fibrinogen levels, and thrombin time. Learning to perform, interpret, and skillfully employ VETs in clinical and operative practice can greatly improve the management of coagulopathic patients who are at increased risk of bleeding or thrombosis.
Enhanced Recovery after Surgery (ERAS) Protocol for Early Discharge within 12 Hours after Robotic Radical Hysterectomy
Authors: Paek Jiheum , Lim Peter C.
Published: February 2022

To evaluate safety of quick discharge after robotic radical hysterectomy (RRH) in a tertiary hospital which has the enhanced recovery after surgery (ERAS) protocol. Among 94 consecutive cervical cancer patients who had undergone RRH, operative outcomes and the rate of unexpected visit after surgery were analyzed retrospectively. Patients were categorized as a surgery-to-discharge time of ≤12 h (early discharge [ED]) or >12 h (late discharge [LD]). About 77% (n = 72) of analyzed 94 patients discharged within 12 h after RRH. The ED group had significant correlation with shorter duration for urinary catheter required, less operative blood loss, and less voiding difficulty after long-term follow up compared to the LD group. There was no difference of perioperative complications and unexpected visit between the two groups. Performing nerve sparing (NS) RRH was only independent predictor for ED (p = 0.043, hazard ratio for LD = 0.22, confidence interval = 0.05–0.95). In conclusion, the ED within 12 h after RRH was safe in the setting of ERAS protocol. The NS-RRH could avoid the delay of genitourinary function recovery after surgery which caused LD. It can become the reasonable clinical pathway to discharge early patients who undergo NS-RRH with ERAS protocol.
Reprocessability of PLA through Chain Extension for Fused Filament Fabrication
Authors: Correia Carlos , Gomes Tiago E. P. , Gonçalves Idalina , Neto Victor
Published: February 2022

As additive manufacturing (AM) technologies have been gaining popularity in the plastic processing sector, it has become a major concern to establish closed-loop recycling strategies to maximize the value of the materials processed, therefore enhancing their sustainability. However, there are challenges to overcome related to the performance of recycled materials since, after mechanical recycling, the molecular degradation of thermoplastics shifts their performance and processability. In this work, it was hypothesized that the incorporation of a chain extender (CE) during the reprocessing would allow us to overcome these drawbacks. To attest this conjecture, the influence of 1,3-Bis(4,5-dihydro-2-oxazolyl)benzene (PBO), used as a CE, on mechanical, thermal, and rheological properties of polilactic acid (PLA) was studied. Furthermore, a closed-loop recycling system based on Fused Filament Fabrication (FFF) was attempted, consisting of the material preparation, filament extrusion, production of 3D components, and mechanical recycling steps. PBO partially recovered the recycled PLA mechanical performance, reflected by an increase in both tensile modulus (+13%) and tensile strength (+121%), when compared with recycled PLA without PBO. Printability tests were conducted, with the material’s brittle behavior being the major constraint for successfully establishing a closed-loop recycling scheme for FFF applications.
Talaromyces marneffei Infection: Virulence, Intracellular Lifestyle and Host Defense Mechanisms
Authors: Pruksaphon Kritsada , Nosanchuk Joshua D. , Ratanabanangkoon Kavi , Youngchim Sirida
Published: February 2022

Talaromycosis (Penicilliosis) is an opportunistic mycosis caused by the thermally dimorphic fungus Talaromyces (Penicillium) marneffei. Similar to other major causes of systemic mycoses, the extent of disease and outcomes are the results of complex interactions between this opportunistic human pathogen and a host’s immune response. This review will highlight the current knowledge regarding the dynamic interaction between T. marneffei and mammalian hosts, particularly highlighting important aspects of virulence factors, intracellular lifestyle and the mechanisms of immune defense as well as the strategies of the pathogen for manipulating and evading host immune cells.
New Findings on the Biology and Ecology of the Ecuadorian Amazon Fungus Polyporus leprieurii var. yasuniensis
Authors: Toapanta-Alban Cristina E. , Ordoñez María E. , Blanchette Robert A.
Published: February 2022

Polyporus leprieurii var. yasuniensis is a prolific wood-decay fungus inhabiting the forest floor of one of the most biodiverse places on earth, the Yasuní National Park in Ecuador. Basidiocarps and aerial rhizomorphs are commonly found growing on woody debris distributed along the floor of this forest ecosystem. Because of the extraordinary abundance of this fungus in the tropical rainforest, we carried out investigations to better understand the biological and ecological aspects contributing to its prolific distribution. Data on growth inhibition in paired competition studies with sixteen fungal isolates exemplifies defense mechanisms used to defend its territory, including pseudosclerotial plates and the development of a melanized rhizomorphic mat. Results of biomass loss on eleven types of tropical wood in microcosm experiments demonstrated the broad decay capacity of the fungus. In and ex situ observations provided information on how long rhizomorphs can prevail in highly competitive ecosystems as well as stressful conditions in the laboratory. Finally, high concentrations of metal ions occur on rhizomorphs as compared to colonized wood. Sequestration of metal ions from the environment by the melanized rhizomorphs may offer protection against competitors. The development of melanized rhizomorphs is key to find and colonize new substrates and resist changing environmental conditions.
Antifungal Activity of Human Cathelicidin LL-37, a Membrane Disrupting Peptide, by Triggering Oxidative Stress and Cell Cycle Arrest in Candida auris
Authors: Rather Irfan A. , Sabir Jamal S. M. , Asseri Amer H. , Ali Sajad
Published: February 2022

Candida auris, an evolving multidrug-resistant pathogenic yeast, is known for causing severe invasive infections associated with high mortality rates in hospitalized individuals. Distinct from other Candida species, C. auris can persist for longer periods on different surfaces and is resistant to all of the major classes of antifungal drugs. Therefore, there is an urgent need for new antimycotic drugs with improved efficacy and reduced toxicity. The development of new antifungals based on antimicrobial peptides from various sources is considered a promising alternative. In this study, we examined the in vitro anti-yeast activity of the human cathelicidin peptides LL-37 against clinical strains of C. auris alone and in combination with different antifungal drugs by broth microdilution assay. To understand the antifungal mechanism of action, cell envelopes, cell cycle arrest, and effect on oxidative stress enzymes were studied using standard protocols. The minimum inhibitory and fungicidal concentrations of cathelicidin LL-37 ranged from 25–100 and 50–200 µg/mL, respectively. A combination interaction in a 1:1 ratio (cathelicidin LL-37: antifungal drug) resulted in 70% synergy with fluconazole and 100% synergy with amphotericin B and caspofungin. Assessment of the C. auris membrane by using propidium iodide assay after exposure to cathelicidin LL-37 linked membrane permeabilization with inhibition of C. auris cell growth and viability. These results were backed up by scanning electron microscopy studies demonstrating that exposure with cathelicidin LL-37 caused C. auris cells to undergo extensive surface changes. Spectrophotometric analysis revealed that cathelicidin LL-37 caused oxidative stress in C. auris, as is evident from the significant increase in the activity of primary antioxidant enzymes. In addition, cathelicidin LL-37 inhibited the cell cycle and accumulated cells in the S phase. Therefore, these results specify the potential of cathelicidin LL-37 for developing a new and effective anti-Candida agent.
The Sociodemographic and Risk Factors for Fuchs’ Endothelial Dystrophy: A Nationwide, Matched Case–Control Study in Taiwan
Authors: Chang Yuh-Shin , Ho Chung-Han , Wang Jhi-Joung , Tseng Sung-Huei , Jan Ren-Long
Published: February 2022

This nationwide, population-based, retrospective, matched case–control study included 4334 newly diagnosed Fuchs’ endothelial dystrophy (FED) patients who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM), code 371.57, and selected from the Taiwan National Health Insurance Research Database. The age-, sex-, and index-date-matched control group included 4334 non-FED controls selected from the Taiwan Longitudinal Health Insurance Database 2000. Ocular allergic conditions and sociodemographic conditions were examined using univariate logistic regression analyses and paired t-test was used for continuous variables. Adjusted logistic regression was used to compare the odds ratio (OR) of the FED development. Patients with ocular allergic conditions were more likely to have FED than the controls (OR = 25.50, 95% CI = 12.58–51.68, p < 0.0001) even after conditional logistic regression was conducted (adjusted OR = 25.26, 95% CI = 11.24–56.77, p < 0.0001). Regarding the sociodemographic factors, we found that more than half of the FED patients in Taiwan were aged ≥45 years old, there was an equal female-to-male ratio (1.06:1), and patients with a lower income and living in northern Taiwan had higher odds of developing FED. The results strongly support an association between ocular allergic conditions, geographic region, residential status, income, and FED.
Health Promotion and Disease Prevention in the Elderly: The Perspective of Nursing Students
Authors: Ferreira Rogério , Baixinho Cristina Lavareda , Ferreira Óscar Ramos , Nunes Ana Clara , Mestre Teresa , Sousa Luís
Published: February 2022

Health promotion and disease prevention are closely linked to health literacy. Therefore, intervention to increase individuals’ knowledge is essential if action is to be taken to promote a healthy lifestyle with support from health professionals for decision making on choices leading to behavioral change. Taking into account the growing aging population, nurses and nursing students have to develop interventions to promote health and prevent disease in these people, in order to keep them healthy and with quality of life. This study aims to understand how nursing students’ experiences in a clinical teaching context contributed to the development of their competencies in the promotion of health and prevention of disease in the elderly. Method: Qualitative, exploratory, and descriptive study carried out with ten students about to finish a graduate nursing course in a higher education institution in the South of Portugal. This study was carried out through narratives, one of the most common data collection procedures in social and health investigations. The content analysis technique, more specifically the thematic categorical analysis, was used for data analysis. The study received authorization from the Ethics Committee of the institution where it took place. Results: Three categories were found: “Strategies to promote health and prevent disease in the elderly”, “Health improvements from the implementation of the strategies to promote health and prevent disease in the elderly”, and “The impact your participation in these strategies to promote health and prevent disease in the elderly had on your formative process”. Conclusion: The students developed competencies during their clinical teaching experiences through the implementation of strategies of health promotion and disease prevention adapted to/focused on the needs of the elderly.
Artificial Intelligence-Enabled Electrocardiogram Estimates Left Atrium Enlargement as a Predictor of Future Cardiovascular Disease
Authors: Lou Yu-Sheng , Lin Chin-Sheng , Fang Wen-Hui , Lee Chia-Cheng , Ho Ching-Liang , Wang Chih-Hung , Lin Chin
Published: February 2022

Background: Left atrium enlargement (LAE) can be used as a predictor of future cardiovascular diseases, including hypertension (HTN) and atrial fibrillation (Afib). Typical electrocardiogram (ECG) changes have been reported in patients with LAE. This study developed a deep learning model (DLM)-enabled ECG system to identify patients with LAE. Method: Patients who had ECG records with corresponding echocardiography (ECHO) were included. There were 101,077 ECGs, 20,510 ECGs, 7611 ECGs, and 11,753 ECGs in the development, tuning, internal validation, and external validation sets, respectively. We evaluated the performance of a DLM-enabled ECG for diagnosing LAE and explored the prognostic value of ECG-LAE for new-onset HTN, new-onset stroke (STK), new-onset mitral regurgitation (MR), and new-onset Afib. Results: The DLM-enabled ECG achieved AUCs of 0.8127/0.8176 for diagnosing mild LAE, 0.8587/0.8688 for diagnosing moderate LAE, and 0.8899/0.8990 for diagnosing severe LAE in the internal/external validation sets. Notably, ECG-LAE had higher prognostic value compared to ECHO-LAE, which had C-indices of 0.711/0.714 compared to 0.695/0.692 for new-onset HTN, 0.676/0.688 compared to 0.663/0.677 for new-onset STK, 0.696/0.695 compared to 0.676/0.673 for new-onset MR, and 0.800/0.806 compared to 0.786/0.760 for new-onset Afib in internal/external validation sets, respectively. Conclusions: A DLM-enabled ECG could be considered as a LAE screening tool and provide better prognostic information for related cardiovascular diseases.
Analysis of the Efficacy of Universal Screening of Coronavirus Disease with Antigen-Detecting Rapid Diagnostic Tests at Point-or-Care Settings and Sharing the Experience of Admission Protocol—A Pilot Study
Authors: Park Ji Young , Lee Joo Hee , Cha Bong Ki , Kim Boo-Seop , Lee Han-Jun , Kim Gi Hyeon , Kang Kyu-Tae , Lee Yong-Soon , Ahn Seok Keun , Kim Seong Hwan
Published: February 2022

Aims: To introduce the admission protocol of a COVID-19 specialized hospital outlined by the government, including the assessment of reverse transcription polymerase chain reaction (RT-PCR), low dose chest computed tomography (CT) and antigen-detecting rapid diagnostic test (Ag-RDT) for patient screening. Materials and Methods: This was a retrospective cohort study of 646 patients who were admitted between December 2020, and February 2021, during the third wave of COVID-19 in Korea. Ag-RDT and RT-PCR were routinely performed on all patients who required admission, and low-dose chest CT was performed on high-risk patients with associated symptoms. Any patients with high-risk COVID-19 infection according to the Ag-RDT test were quarantined alone in a negative pressured room, and those with low-risk COVID-19 infection remained in the preemptive quarantine room with or without negative pressure. The diagnostic values of the Ag-RDT test and associated cycle threshold (Ct) values of the RT-PCR test were subsequently evaluated. Results: In terms of the diagnostic value, the Ag-RDT for COVID-19 had a sensitivity of 68.3%, specificity of 99.5%, positive predictive value (PPV) of 90.3%, and negative predictive value (NPV) of 97.9%. For the 355 symptomatic patients with low-dose chest CT, the diagnostic values of combined evaluations had a sensitivity of 90.2%, specificity of 99.0%, PPV of 86.1%, and NPV of 99.3%. The cut-off Ct value for positive Ag-RDT was ≤25.67 for the N gene (sensitivity: 89.3%, specificity: 100%), which was regarded as a high viable virus in cell culture. There were no patients or medical staff who had COVID-19 in the hospital. Conclusion: Appropriate patient care was possible by definitive triage of the area, according to the symptoms and using diagnostic tests. Screening protocols, including the Ag-RDT test and low-dose chest CT, could be helpful in emergency point-of-care settings.
A Comparative Analysis of the Nature of Stock Return Volatility in BRICS and G7 Markets
Authors: Muguto Lorraine , Muzindutsi Paul-Francois
Published: February 2022

Through globalization and financial market liberalization, the opening up of markets has increased cross-border investments as investors search for higher risk-adjusted returns. This ability to invest internationally has raised the attention given to emerging markets that offer higher risk-adjusted returns relative to developed markets. However, despite the growing importance of emerging markets, the literature on the nature of volatility in global markets is typified by generalizations of findings from developed markets. To fill this gap, this study comparatively examined the nature of stock return volatility in developed G7 and emerging BRICS markets. Broad market index data and GARCH models over the period 2003:01–2020:08 were employed. The study found evidence of volatility persistence, asymmetry, mean reversion and weak evidence of a risk premium in both emerging and developed markets. There was also evidence of significant differences in the nature of volatility within the two sets of markets. These volatility patterns in both groups cast doubt on the assertion that developed markets are more informationally efficient than emerging markets. Thus, markets in the same group may not always have the same nature of volatility, especially in the wake of structural events such as the COVID-19 global pandemic.
Urban Leverage and Housing Price in China
Authors: Lu Wanying , Shen Jianfu
Published: February 2022

This paper examines whether urban leverage, defined by the bank loan-to-deposit ratio in a city, affects housing prices in China. Using a panel dataset of 236 cities and hedonic models, we find a depressing effect of urban leverage on housing price in first- and second-tier cities while leaving third- and fourth-tier cities unaffected. Urban leverage negatively affects housing prices by influencing credit supply. Moreover, the difference-in-differences analysis indicates that purchase restriction policies amplify the depressing effect of urban leverage on housing prices. Overall, we show that urban leverage is an important determinant of housing prices in China.
Self-Weighted LSE and Residual-Based QMLE of ARMA-GARCH Models
Authors: Ling Shiqing , Zhu Ke
Published: February 2022

This paper studies the self-weighted least squares estimator (SWLSE) of the ARMA model with GARCH noises. It is shown that the SWLSE is consistent and asymptotically normal when the GARCH noise does not have a finite fourth moment. Using the residuals from the estimated ARMA model, it is shown that the residual-based quasi-maximum likelihood estimator (QMLE) for the GARCH model is consistent and asymptotically normal, but if the innovations are asymmetric, it is not as efficient as that when the GARCH process is observed. Using the SWLSE and residual-based QMLE as the initial estimators, the local QMLE for ARMA-GARCH model is asymptotically normal via an one-step iteration. The importance of the proposed estimators is illustrated by simulated data and five real examples in financial markets.
GIAHS as an Instrument to Articulate the Landscape and Territorialized Agrifood Systems—The Example of La Axarquía (Malaga Province, Spain)
Authors: Silva-Pérez Rocío , González-Romero Gema
Published: February 2022

The theoretical literature makes a connection between the notions of landscape and territorialised agrifood systems, but these connections are rarely specified or explained. Their consideration in development proposals requires the relationship between the two and their magnitude to be made explicit. This article enquires into this and explores its programmatic forecasts from both the theoretical and empirical perspectives. An epistemological and regulatory review points to the FAO Globally Important Agriculture Heritage System (GIAHS) programme as the instrument that articulates the logic of landscape and territorialised agrifood in marginal rural areas. The empirical part of the study focuses on the dried grape (raisin) agrifood system in Axarquía (Malaga province, Spain) GIAHS since 2018. Territorial recognition and semi-structured interviews have enabled a deep study of the praxis of these connections. Axarquía is seen to be an excellent laboratory of the synergies between territorialised agrifood system synergies and landscapes. GIAHS is substantiated as a virtual instrument that can contribute to agriculture-based territorial development. It acts as a stimulus to development and combines forces through territorial governance processes. It highlights the value of agriculture as a cornerstone of development, examines agricultural functionalities in detail, and gives meaning to agricultural landscapes.
Effectiveness of Lifestyle Modification in Polycystic Ovary Syndrome Patients with Obesity: A Systematic Review and Meta-Analysis
Authors: Kim Chan-Hee , Lee Seon-Heui
Published: February 2022

(1) Background: Polycystic ovary syndrome (PCOS) is the most common cause of anovulatory infertility and endocrine disorders among women of reproductive age. Previous studies have employed lifestyle interventions to manage anovulatory infertility and endocrine disorders. However, the effect of lifestyle interventions on the metabolic index remains ambiguous; (2) Methods: Data were obtained through a systematic search of the Ovid-Medline, Ovid-EMBASE, and Cochrane Library databases. Two reviewers independently reviewed the literature in two stages. A consensus was achieved through discussions regarding the final selection of the literature; (3) Results: This study observed that the group that underwent lifestyle modifications displayed significant improvement in reproductive function compared to the control group. Combination therapy with diet and exercise resulted in improved fasting insulin levels, compared to monotherapy with diet or exercise. Moreover, moderate weight loss (a minimum of 5%) resulted in an improved metabolic index. The subgroup analysis revealed that the group that underwent lifestyle modifications had a significantly higher number of patients with improved menstrual cycles, compared to the control groups; (4) Conclusions: Lifestyle modification using combination therapy is a promising therapeutic approach that can be employed in the management of PCOS patients with obesity. This scenario warrants further studies with larger sample sizes to develop ideal treatment protocols.
Computer Aided Drug Design Approach to Screen Phytoconstituents of Adhatoda vasica as Potential Inhibitors of SARS-CoV-2 Main Protease Enzyme
Authors: Siva Kumar Bathula , Anuragh Singh , Kammala Ananth Kumar , Ilango Kaliappan
Published: February 2022

A novel coronavirus (COVID-19) was identified as one of the severe acute respiratory syndrome coronaviruses (SARS-CoV-2) and emerged as a pandemic in 2020. Thus, there is an urgent need to screen and develop an agent to suppress the proliferation of viral particles of SARS-CoV-2, and several drugs have entered clinical trial phases to assess their therapeutic potential. The objective of the present study is to screen phytochemicals against the main viral protease using molecular docking studies. The phytochemicals vasicine, vasicinone, vasicinolone, vasicol, vasicolinone, adhatodine, adhavasicinone, aniflorine, anisotine, vasnetine, and orientin from Adhatoda vasica were selected, and the compounds were docked with various viral protein targets, including specific SARS-CoV-2 main protease (PDBID:6Y84), using AutoDock, Schrodinger, Biovia discovery studio, and virtual screening tools. Adhatodine and vasnetine showed a better binding affinity of −9.60 KJ/mol and −8.78 KJ/mol, respectively. In molecular docking simulations for 10 ns, these compounds illustrated strong hydrogen-bonding interactions with the protein active site and induced a potential conformational change in the ligand-binding site. The results were compared with the antiviral drugs nirmatrelvir and ritonavir. These results suggest that these phytochemicals can be studied as potential inhibitors against SARS-CoV-2 protease and may have an antiviral effect on coronavirus. However, further in vitro and in vivo efficacy activity needs to be investigated for these phytochemicals.
Association between Serum Adipocyte Fatty Acid Binding Protein Level and Endothelial Dysfunction in Chronic Hemodialysis Patients
Authors: Fan Hsin-Jou , Wang Chih-Hsien , Hsu Bang-Gee , Tsai Jen-Pi
Published: February 2022

Adipocyte fatty acid binding protein (A-FABP) is associated with atherosclerosis, and endothelial dysfunction is one of the reasons for adverse cardiovascular outcomes in patients undergoing hemodialysis (HD). This study investigated the correlation between serum A-FABP levels and endothelial function in HD patients. Fasting blood samples were collected from 90 HD patients. A-FABP levels were measured using a commercial enzyme immunoassay kit. Endothelial function was evaluated by a digital thermal monitoring test to measure vascular reactivity index (VRI). VRI < 1.0, 1.0 ≤ VRI < 2.0, and VRI ≥ 2.0 indicated poor, intermediate, and good vascular reactivity, respectively. In total, 14 (15.6%), 38 (42.2%), and 38 (42.2%) HD patients had poor, intermediate, and good VRI, respectively. Patients with poor VRI had lower pre-HD and post-HD body weight, body mass index, and serum creatinine level but higher serum A-FABP level (p = 0.001) than those with intermediate and good VRI. Log-transformed VRI (log-VRI) positively correlated with serum creatinine and negatively correlated with A-FABP by multivariate linear regression analysis. We concluded that A-FABP correlated with endothelial dysfunction in chronic HD patients.
Impact of Graphene Nano-Additives to Lithium Grease on the Dynamic and Tribological Behavior of Rolling Bearings
Authors: Nassef Mohamed G. A. , Soliman Mina , Nassef Belal Galal , Daha Mohamed A. , Nassef Galal A.
Published: February 2022

In recent years, reduced graphene oxide (rGO) received considerable interest as a lubricant nano-additive for enhancing sliding and rolling contacts. This paper investigates the tribological and dynamic behavior of ball bearings lubricated by lithium grease at different weight percentages of rGO. Full bearing tests were conducted for experimental modal analysis, vibration analysis, ultrasonic analysis, and infrared thermography. Modal analysis indicated considerable improvements of the damping ratio values up to 50% for the bearings with rGO nano-additives. These findings were confirmed by the corresponding reductions in vibrations and ultrasound levels. The steady-state temperatures of bearings running with lithium grease reached 64 °C, whereas the temperature of bearings lubricated by grease with 2 wt.% rGO measured only 27 °C. A Timken Load test was conducted on grease samples with and without rGO additives. Grease samples having 2, 3.5, and 5 wt.% rGO showed the highest OK load with an increase of 25%, 50%, and 100% as compared to values of lithium grease. For comparison, all tests were conducted on samples of the same grease blended with graphite and MWCNTs’ nano-additives. The results proved the superiority of graphene in enhancing the load-carrying capacity and damping of grease in rolling bearings.
Performance Evaluation of Dental Flosses Pre- and Post-Utilization
Authors: Stavrakis Adrian K. , Kojić Sanja , Petrović Bojan , Nešković Isidora , Stojanović Goran M.
Published: February 2022

Dental floss is an oral hygiene product used to remove food and plaque in places where toothbrushes cannot reach. Even though over the years since its introduction some research in suitable materials has been performed, thread cracking and wear can still compromise efficiency. The aim of this study was to examine the morphological properties of four different commercially available dental floss types before and after use. For that purpose, scanning electron microscopy and optical microscopy were used to assess the flosses before and after use, and tension testing was performed to determine any degradation in the floss performance after utilization. The analyzed floss samples verify the hypothesis that the properties of the floss need to be known in depth, before recommending a specific type to patients for daily use in all clinical indications.
Synthesis and Structural Characterization of CaO-P2O5-CaF:CuO Glasses with Antitumoral Effect on Skin Cancer Cells
Authors: Vedeanu Nicoleta Simona , Lujerdean Cristian , Zăhan Marius , Dezmirean Daniel Severus , Barbu-Tudoran Lucian , Damian Grigore , Ștefan Răzvan
Published: February 2022

Copper is one of the most used therapeutic metallic elements in biomedicine, ranging from antibacterial approaches to developing new complexes in cancer therapy. In the present investigation, we developed a novel xCuO∙(100 − x) [CaF2∙3P2O5∙CaO] glass system with 0 ≤ x ≤ 16 mol% in order to determine the influence of doping on the composition structure of glasses. The samples were characterized by dissolution tests, pH measurements, Fourier-transform infrared spectroscopy (FT-IR), electron paramagnetic resonance (EPR), Scanning Electron Microscopy with energy dispersive spectroscopy (SEM-EDX) and afterward, their antitumor character was assessed. The glasses were mostly soluble in the aqueous medium, their dissolution rate being directly proportional to the increase in pH and the level of doping up to x = 8 mol%. FT-IR spectra of glass samples show the presence of all structural units characteristic to P2O5 in different rates and directly depending on the depolymerization process. SEM-EDX results revealed the presence of an amorphous glass structure composed of P, O, Ca, and Cu elements. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay showed strong cytotoxicity for tumoral cells A375 even in low concentrations for Cu-treatment. In contrast, the copper-free matrix (without Cu) determined a proliferative effect of over 70% viability for all concentrations used.
Global and Local Deformation Effects of Dry Vacuum-Consolidated Triaxial Compression Tests on Sand Specimens: Making a Database Available for the Calibration and Development of Forward Models
Authors: Medina-Cetina Zenon , Song Ahran , Zhu Yichuan , Pineda-Contreras Alma Rosa , Rechenmacher Amy
Published: February 2022

A comprehensive experimental database containing results of a series of dry vacuum-consolidated triaxial compression tests was populated. The tests were performed on sand specimens and conducted under similar experimental conditions, in which specimens’ boundary deformation was captured using a three-dimensional digital image correlation analysis (3D-DIC). The use of a standard triaxial device along with the 3D-DIC technology allowed the specimens’ global and local boundary displacement fields to be computed from start to end of the compression phase. By repeating each test under the same experimental conditions and building the specimens using the same type of sand, the boundary deformation patterns could be identified, and the statistics associated with both global and local displacement fields could be assessed. Making this experimental database available to others should serve to calibrate as well as develop new forward models to account for effects associated with the specimens’ local displacements and material heterogeneity and include statistics to represent a specimen’s random response. Moreover, this work will serve as a basis for the statistical characterization of spatio-temporal boundary localization effects used to develop stochastic models and machine-learning models, and simulate virtual triaxial tests.
Effect of Electromagnetic Field on Wear Resistance of Fe901/Al2O3 Metal Matrix Composite Coating Prepared by Laser Cladding
Authors: Chen Yaobang , Zhou Jianzhong , Li Pengfei , Huo Kun , Meng Xiankai
Published: February 2022

Fe901/Al2O3 metal matrix composite (MMC) coatings were deposited on the surface of 45 steel via electromagnetic field (EF)-assisted laser cladding technology. The influences of EF on the microstructure, phase composition, microhardness, and wear resistance of the Fe901/Al2O3 MMC coating were investigated. The generated Lorentz force (FL) and Joule heating due to the application of EF had a positive effect on wear resistance. The results showed that FL broke up the columnar dendrites. Joule heating produced more nuclei, resulting in the formation of fine columnar dendrites, equiaxed dendrites, and cells. The EF affected the content of hard phase in the coatings while it did not change the phase composition of the coating, because the coatings with and without EF assistance contained (Fe, Cr), (Fe, Cr)7C3, Fe3Al, and (Al, Fe)4Cr phases. The microhardness under 20 mT increased by 84.5 HV0.2 compared to the coating without EF due to the refinement of grains and the increased content of hard phase. Additionally, the main wear mechanism switched from adhesive wear to abrasive wear.
The Effect of POFA-Gypsum Binary Mixture Replacement on the Performance of Mechanical and Microstructural Properties Enhancements of Clays
Authors: Alhokabi Abdulmajeed , Hasan Muzamir , Amran Mugahed , Fediuk Roman , Vatin Nikolai , Alshaeer Honin
Published: February 2022

Soft clay is categorized as problematic due to its weak and dispersive properties which requires stabilization. In Malaysia, there is another challenge, the increment of palm oil waste productions to meet the global demand for food oil. These two concerns motivate engineers to develop novel strategies for exploiting palm oil waste in soil stabilization. Utilizing POFA as a soil stabilizing agent is an economical and sustainable option due to that POFA contains high pozzolanic characteristics which make it more suitable and reliable to treat soft soil. This study uses the replacement portion of the soil with stabilizing agents -POFA and Gypsum; aiming to achieve Malaysia green technology goals by the balance of the economic expansion and environmental privilege. However, the aim of this study is to determine the effect of POFA-gypsum binary mixture replacement on the performance of mechanical and microstructural properties en-hancements of clays. Kaolin S300 is the control sample whereas POFA and gypsum are the used binders. The mechanical properties and shear strength with the curing period were tested. Results showed that treated clay marked increment of optimum water contents and reduction of maximum dry densities, a clear 200% of enhancement of treated clay’s compressive and shear strength with curing period as well as the amount of stabilizing agent to less than 15% of POFA and 6% of POFA. It is also found that as gypsum contains a high amount of lime (CaO), the results illustrate that strength raises significantly even with less curing time due to its high reactivity compared to silica and alu-mina. Overall, the results show an enhancement of mechanical and shear strength properties of treated kaolin supported by microstructural SEM imaging.
Mutual Effect of Components of Protective Films Applied on Copper and Brass from Octadecylamine and 1,2,3-Benzotriazole Vapors
Authors: Goncharova Olga A. , Luchkin Andrey Yu. , Andreeva Nina P. , Kasatkin Vadim E. , Vesely Sergey. S. , Andreev Nikolay N. , Kuznetsov Yurii I.
Published: February 2022

It has been shown by a set of corrosion, electrochemical and physical methods that a chamber corrosion inhibitor that consists of a mixture of octadecylamine (ODA) and benzotriazole (BTA) efficiently protects copper and brass from atmospheric corrosion and can be used for the temporary protection of metal items. The optimum temperatures of treatment with the ODA + BTA mixed inhibitor is 120 °C for brass and 100 °C for copper. One-hour treatment in ODA + BTA vapors at these temperatures results in the formation of nanosized adsorption films on the surface of these metals. These films stabilize the passive state and provide efficient temporary protection of metal items. The ODA + BTA inhibitor is superior to its components in terms of protective aftereffect. Our analysis of the mutual effect of BTA and ODA indicated that they show an antagonism of protective action on copper, but there is also a synergistic enhancement in the case of brass. Electrochemical impedance spectroscopy studies demonstrate that the inhibitors in question mainly act by using a blocking mechanism on copper and brass. Chamber treatment of the metals studied in vapors of the ODA + BTA mixture resulted in a noticeable hydrophobization of the copper surface and an insignificant effect on the brass surface. Chamber treatment of copper samples with artificially created polymodal roughness made it possible to obtain a superhydrophobic surface.
Acoustic Insulation Mechanism of Membrane-Type Acoustic Metamaterials Loaded with Arbitrarily Shaped Mass Blocks of Variable Surface Density
Authors: Li Junyu , Shi Yuanyuan , Jiang Renjie , Zhang Zhifu , Huang Qibai
Published: February 2022

Membrane-type acoustic metamaterials (MAMs) have recently received widespread attention due to their good low-frequency sound-transmission-loss (STL) performance. A fast prediction method for the STL of rectangular membranes loaded with masses of arbitrary shapes and surface density values is proposed as a semi-analytical model for calculating the STL of membrane-type acoustic metamaterials. Through conformal mapping theory, the mass blocks of arbitrary shapes were transformed into regular shapes, which simplified the calculation model of acoustic propagation loss prediction, and the prediction results were verified by finite element simulations. The results show that the change in mass surface density was closely related to the size and frequency distribution of STL. The influence of the mass center on the STL and characteristic frequency of the film metamaterial is discussed.