bluuebunny/crossref_metadata_2025 huggingface dataset:
Graphical Interface Design for Water Pumping Process which Works with a Hydrophore
Authors: Costea C. R. , Silaghi Helga , Matica Liliana , Gergely E. , Husi G. , Coroiu Laura
Published: November 2016

In this paper, the application of water pumping process is presented. This article presents the design of a human machine interface. Using this interface, it can be possible to track the evolution of pumping water flow. The applications consists of water pumping process simulation. Also, are illustrated and analyzed several cases, depending on the water flow which is inside the tank.
Biomonitoring Laboratory Oriented to Software Applications Development
Authors: Paţurcă Sanda Victorinne , Grigorescu S.D.
Published: November 2016

This paper presents a project-oriented laboratory. It is intended to provide an educational and research environment that stimulates innovative solutions in the growing field of Bioengineering. The authors took the advantages of the emerging technology and the increasing popularity of wearable biomonitoring devices, to teach students the key elements regarding the application of Information Technology in health monitoring. The students were involved in a complex project, along which they gain basic knowledge about the software development for biomonitoring, and apply it to effectively develop common structures and software applications. There are presented the stages of the laboratory work, with illustrations of the applications implementation at different levels of the hierarchy, starting from collecting data from the biomonitoring device, and finalizing with the data visualization by the end-user.
New Pumped Storage Plants as Renewable Energy Sources in Romania
Authors: Popa F. , Alexescu C. , Popa B.
Published: November 2016

In Romania, there are no pumped storage plants (PSPs) significant from the point of view of the National Power System (NPS). For more than 30 years, one site is expected to achieve 1000 MW PSP, using the existing reservoir Tarnita, on Somes river, as the lower reservoir. Recently, Hidroelectrica launched a study identifying new potential sites for PSPs in the Eastern part of Romania, where there is a huge development for wind farms and where Cernavoda nuclear power plant is located, with 2 units of 700 MW each in operation and other 2 units to be built until 2035. These PSPs will cover the ancillary services and, according to a new Government Ordinance, will enable a better integration of the existing RES into the NPS, and will increase the generation of electricity from RES by their own production of electricity.
Estimation of spatial variability of lignite mine dumping ground soil properties using CPTu results
Authors: Bagińska Irena , Kawa Marek , Janecki Wojciech
Published: November 2016

The paper deals with application of CPTu test results for the probabilistic modeling of dumping grounds. The statistical measures use results from 42 CPT test points located in the lignite mine dumping ground from the region of Central Europe. Both the tip resistance qc
as well as local friction fs
are tested. Based on the mean values and standard deviations of measured quantities the specific zones in the dumping site profile are distinguished. For three main zones standard deviations of linearly de-trended functions, distributions of normalized de-trended values for qc
and fs
are examined. Also the vertical scales of fluctuation for both measured quantities are estimated. The obtained result shows that lignite mine dumping site can be successfully described with the Random Field Theory. Additional use of fs
values introduces supplementary statistical information.
Stochastic Finite Element Analysis using Polynomial Chaos
Authors: Drakos S. , Pande G.N.
Published: November 2016

This paper presents a procedure of conducting Stochastic Finite Element Analysis using Polynomial Chaos. It eliminates the need for a large number of Monte Carlo simulations thus reducing computational time and making stochastic analysis of practical problems feasible. This is achieved by polynomial chaos expansion of the displacement field. An example of a plane-strain strip load on a semi-infinite elastic foundation is presented and results of settlement are compared to those obtained from Random Finite Element Analysis. A close matching of the two is observed.
The influence of normal fault on initial state of stress in rock mass
Authors: Tajduś Antoni , Cała Marek , Tajduś Krzysztof
Published: November 2016

Determination of original state of stress in rock mass is a very difficult task for rock mechanics. Yet, original state of stress in rock mass has fundamental influence on secondary state of stress, which occurs in the vicinity of mining headings. This, in turn, is the cause of the occurrence of a number of mining hazards, i.e., seismic events, rock bursts, gas and rock outbursts, falls of roof. From experience, it is known that original state of stress depends a lot on tectonic disturbances, i.e., faults and folds. In the area of faults, a great number of seismic events occur, often of high energies. These seismic events, in many cases, are the cause of rock bursts and damage to the constructions located inside the rock mass and on the surface of the ground. To estimate the influence of fault existence on the disturbance of original state of stress in rock mass, numerical calculations were done by means of Finite Element Method. In the calculations, it was tried to determine the influence of different factors on state of stress, which occurs in the vicinity of a normal fault, i.e., the influence of normal fault inclination, deformability of rock mass, values of friction coefficient on the fault contact. Critical value of friction coefficient was also determined, when mutual dislocation of rock mass part separated by a fault is impossible. The obtained results enabled formulation of a number of conclusions, which are important in the context of seismic events and rock bursts in the area of faults.
Effects of Divalent Cations on Outward Potassium Currents in Leech Retzius Nerve Cells
Authors: Jovanovic Zorica , Mihaljevic Olgica , Kostic Irena
Published: November 2016

The present study examines the effects of divalent metals, cadmium (Cd2+) and manganese (Mn2+), on the outward potassium currents of Retzius cells in the hirudinid leeches Haemopis sanguisuga using conventional two-microelectrode voltageclamp techniques. The outward potassium current is activated by depolarization and plays an important role in determining both the neuronal excitability and action potential duration. A strong inhibition of the fast current and a clear reduction in the late currents of the outward current with 1 mM Cd2+were obtained, which indicated that both components are sensitive to this metal. Complete blockage of the fast and partial reduction of the slow outward currents was observed after adding 1 mM Mn2+to the extracellular fluid. These data show that the outward K+current in leech Retzius nerve cells comprises at least two components: a voltage-dependent K+current and a Ca2+- activated K+current. These observations also indicate that Cd2+is more eff ective than Mn2+in blocking ion fl ow through these channels and that suppressing Ca2+-activated K+outward currents can prolong the action potential in nerve cells.
Anatomical Parameters of the Acetabulum in Heavy Vehicle Operators
Authors: Jeremic Dejan , Vulovic Maja , Macuzic Ivana Zivanovic , Ivosevic Anita , Grbovic Vesna , Sekulic Igor , Djordjevic Dusica
Published: November 2016

It has been suggested that long-term exposure by heavy vehicle operators to whole-body vibration (WBV) may be related to an increased risk of pathological changes in the anatomical parameters of the hip. The aim of this study was to explore the difference in anatomical parameters of acetabulum in drivers of heavy vehicles (experimental group; n=60) and subjects who have not been exposed to WBV (control group; n=60). The anteroposterior radiographic view of the hips was used to measure the following parameters: the vertical centre edge (VCE), the ‘horizontal toit externe’ angle (HTE), the neck shaft angle (NSA) and the acetabular depth (AD). Compared with the control group, the mean VCE angle values and AD were signifi cantly lower, while the average HTE and NSA values were signifi cantly higher in the experimental group. This study supports the hypothesis that exposure to whole-body vibration during operation of a vehicle causes an increased risk of acetabular dysplasia.
Correlations Between Clinical Parameters and Health-Related Quality of Life in Postmenopausal Osteoporotic Women
Authors: Grbovic Vesna , Skevin Aleksandra Jurisic , Ilic Katarina Parezanovic , Tomic Aleksandra Lucic , Nurkovic Jasmin , Jeremic Dejan , Djordjevic Dusica
Published: November 2016

The purpose of this study was to assess the correlation between health-related quality of life (HRQoL) and clinically relevant osteodensitometric and biochemical parameters in postmenopausal osteoporotic women. Bone mineral density (BMD) and T scores of the lumbar vertebrae and femoral neck were assessed in 100 osteoporotic women (56 without previous fractures and 44 with previous fractures) using dual x-ray absorptiometry. The Fracture Risk Assessment Tool (FRAX) index for major osteoporotic and hip fractures was calculated based on demographic data and hip BMD. Venous blood samples were taken from each subject for biochemical analysis (serum calcium, phosphorus, alkaline phosphatase and vitamin D levels). HRQoL was assessed using the QUALEFFO-41 questionnaire (domains: Health perception, Pain, and Physical, Social and Mental function). Basic participant characteristics (age, menopause length, body mass index, smoking habits, hereditary tendency towards fracture, fracture history) correlated with some of the QUALEFFO-41 domains, but the correlation coefficients were low (r<0.3), except in the case of the correlation between Pain and fracture history (r=0.638). Of the six variables included in the multiple regression model, fracture history was shown to be the most significant predictor with respect to the following three QUALEFFO-41 domains: Pain (b=20.511), Social function (b=2.548) and Health perception (b=3.185). Correlation analysis showed that after adjustment for basic characteristics, BMD and T score of the femoral neck and Pain (r=0.331 and r=0.449, respectively), Social function (r=0.422 and r=0.419) and Health perception (r=0.434 for T score of the femoral neck) exhibited the strongest correlations. Vitamin D was negatively correlated with Mental function, while the other biochemical parameters exhibited variable correlations with the QUALEFFO- 41 domains (r≈0.2-0.5). Our study confirmed the previously established relationship between BMD of the femoral neck and HRQoL in patients with osteoporosis and demonstrated correlations between various blood bone metabolism parameters and HRQoL that have not been previously investigated.
Higher Serum Uric Acid Levels in Multiple Sclerosis Patients After Longterm Interferon Beta Treatment
Authors: Toncev Gordana , Vesic Katarina , Aleksic Dejan , Lazarevic Snežana
Published: November 2016

Interferon beta is a safe and efficacious treatment for relapsing multiple sclerosis (MS). However, there is some evidence that uric acid, a scavenger of peroxynitrite, is involved in MS pathology and that increasing serum uric acid levels might have beneficial therapeutic effects. The aim of this study is to investigate serum uric acid levels in MS patients before and after long-term interferon beta treatment. Blood samples from 101 MS patients (53 receiving interferon beta 1a treatment and 48 receiving interferon beta 1b treatment; 28 male and 73 female; mean age at treatment onset 32,4±7,3 years; mean duration of disease at treatment onset 5,1±3,2 years; mean EDSS 2±1,3) before and after interferon beta treatment (mean treatment duration 3±2 years) were analysed. Serum uric acid levels were measured using a quantitative enzymatic assay (Elitech Diagnostic, Sees, France). MS patients had significantly increased serum uric acid levels after treatment compared with those at the beginning of treatment (272,31±78,21 μmol/l vs. 210,17±53,65 μmol/l; p=0,019, Wilcoxon Mann-Whitney U-test). We did not find significant differences in serum uric acid levels between the interferon beta 1a and interferon beta 1b groups (p=0.98). These results indicate that one of the beneficial effects of interferon beta in MS might be based on the elevation of serum uric acid levels as a natural scavenger of peroxynitrite.
Usage of Intramammary Antimicrobial Veterinary Medicinal Products in The Republic of Serbia from 2011 to 2014
Authors: Andjelkovic Jelena , Radonjic Vesela
Published: November 2016

Prudent use of antimicrobial medicine is an imperative in both human and veterinary medicine today. Antibiotic usage in humans and animals has increased over the years, consequently giving rise to antimicrobial resistance in pathogenic microorganisms. Mastitis is one of the most common conditions in bovine species, and intramammary antibacterial medicinal products are used in animal husbandry for mastitis treatment and prophylaxis.

This paper presents the quantities of intramammary antibiotics sold in the Republic of Serbia from 2011 to 2014 based on data reported to the Medicines and Medical Devices Agency of Serbia by Marketing Authorization Holders. Furthermore, we assessed the number of treated cows and compared those results with the reported total number of cows in the same time period, providing information on animal exposure to particular antibiotics.

In 2011 and 2012, beta-lactams were the most commonly used antimicrobials, while beta-lactams in combination with other substances were the most commonly used antibiotics in 2014, with a total of 80,927 treated animals. From 2011 to 2014, 15-25% of cows were treated with intramammary antimicrobials.

Bearing in mind the growing importance of antibiotic resistance in humans and animals, these results reveal the scope of the potential human exposure to antibiotics via consumption of the milk of treated cows.
The Influence of Different Types of Physical Activity on The Redox Status of Scuba Divers
Authors: Radojevic-Popovic Radmila , Nikolic Tamara , Stojic Isidora , Jeremic Jovana , Srejovic Ivan , Pesic Goran , Jakovljevic Vladimir
Published: November 2016

The effect of scuba diving on ROS production and oxidative stress compared to that of other recreational activities is still poorly understood. The aim of this study was to assess the influence of different types of physical activity on the redox status of scuba divers by testing the pro- and anti-oxidative parameters immediately before and after different types of physical load. The prevalence study included 10 professional police divers. All examinees were male, 32 ± 5.1 years of age, well-trained, and with a minimum of five to a maximum of 20 years of diving experience. The study was divided into three experimental protocols: 1) an exercise test (at atmospheric pressure), 2) an at sea dive (30 meters for 30 minutes), and 3) a dive into river current (10 meters for 30 minutes). Immediately before and after the load test of the divers at atmospheric pressure and immediately before and after the dive, blood samples were taken to determine the values of the following pro-oxidant markers: O2
−, H2O2, NO2
− and TBARS, as well as antioxidant enzymes (SOD and CAT). A comparison of the results before and after physical activity for all three protocols revealed a significant increase in values for NO2
−, O2
−, H2O2 and CAT after physical activity. It can be concluded that the values of all oxidative stress markers depend on the season of the year in which the research is conducted or on the frequency of dives and degree of physical exertion during this period of the year.
Synthesis, Characterization, and Cytotoxicity of Binuclear Cooper(II)-Complexes with some S-Alkenyl Derivatives of Thiosalicyclic Acid
Authors: Tomovic Dusan Lj. , Bukonjic Andriana M. , Kocovic Aleksandar , Nikolic Milos V. , Mijajlovic Marina Z. , Jevtic Verica V. , Ratkovic Zoran R. , Arsenijevic Aleksandar N. , Milovanovic Jelena Z. , Stojanovic Bojana , Trifunovic Srecko R. , Radic Gordana P.
Published: November 2016

New complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (alkenyl = propenyl-(L1), isobutenyl-(L2)) have been synthesized and characterized by microanalysis, infrared spectra, magnetic measurements, and by NMR spectra. The cytotoxic activity of two newly synthesized precursor S-alkenyl derivatives of thiosalicylic acid were tested using an MTT colorimetric technique on HCT-116 human colon carcinoma cells. The cytotoxic effect of the copper(II)- complexes were higher compared to the cytotoxicity of the corresponding ligand (for concentrations from 31.25 to 250 μM). Copper(II)-complexes showed a slightly lower cytotoxicity compared to cisplatin. Complexes of copper(II) with S-alkenyl derivatives of thiosalicylic acid (at concentrations from 250 to 1000 μM) had a cytotoxic effect on HCT-116 cells compared to cisplatin.
Impact of the Crosslinker’s Molecular Structure on the Aggregation of Gold Nanoparticles
Authors: Deffner Michael , Schulz Florian , Lange Holger
Published: November 2016

We studied the aggregation of AuNP induced by small aromatic molecules under different conditions. In water, the aggregation was found to be difficult to control. Phase transfer of the particles into toluene by using oleylamine as a ligand allows for a more controlled and reliable synthesis. Using nonane-1,9-dithiol as a control, our experiments demonstrate that the molecular structure of the linker has a decisive influence on the aggregation. Aromatic dithiols yielded spherical aggregates in the range of 100 nm, whereas the aliphatic linker produced large aggregates in the µm range. The length of the aromatic linker (2 vs. 3 phenylene units) strongly affected aggregation kinetics and the structure of the produced aggregates. With UV/Vis and DLS based experiments it was possible to distinguish the process of ligand layer formation and aggregation. Our results will help to develop syntheses of defined spherical aggregates and possibly more complex structures.
Wernicke Encephalopathy in Adolescents After Bariatric Surgery: Case Report and Review
Authors: Armstrong-Javors Amy , Pratt Janey , Kharasch Sigmund
Published: November 2016

Roughly 1% of all weight loss surgery is performed in adolescents. There is strong evidence demonstrating significant postsurgical weight loss, improvement in quality of life, and reduction in comorbidities such as hypertension and diabetes. Reports of postoperative complications in adolescents are few because of the small sample size in most series. Despite vitamin supplementation, nutritional deficiencies requiring hospitalization occur occasionally after Roux-en-Y gastric bypass. Wernicke encephalopathy, a triad of ophthalmoplegia, ataxia, and altered mental status, is a serious consequence of thiamine (vitamin B1) deficiency. Few cases of Wernicke encephalopathy after weight loss surgery have been reported in the literature and even fewer in the pediatric population. Here we describe a teenage girl who develops vomiting after Roux-en-Y gastric bypass and presented with nystagmus, irritability, and ataxia. The clinical presentation, diagnosis, and treatment of Wernicke encephalopathy in adolescents after bariatric surgery are discussed.
Preparation of apple spirit by ceramic pervaporation membrane
Authors: Molnár M.A. , Márki E. , Vatai Gy.
Published: November 2016

This study was based on the production of an alcoholic beverage from apple using laboratory pervaporation equipment. Hungarian fruit brandy is called pálinka, which can be made by pot distiller or multistage distiller made of copper. In case of traditional pot still distillation the final product is gained from two separate distillations. Pervaporation is an energy efficient membrane process for separating liquid mixtures. Application of pervaporation to separate the product of the initial distillation leads to lower energy consumption than using double-distillation process. The aim of our work was to develop an alternative technology for the production of pálinka that integrates distillation and pervaporation.
Gangliosides in dairy products: Milk sphingolipids
Authors: Potočki S.
Published: November 2016

Milk gangliosides have gained considerable attention because they participate in diverse biological processes, including neural development, pathogen binding, and activation of the immune system. The aim of this study was to determine the concentrations of total gangliosides in dairy products and to determine whether there is a significant difference in comparison to concentration of gangliosides in cow’s milk. The concentration of total gangliosides in dairy products was significantly higher than concentration in cow’s milk. The highest concentration of gangliosides was determined in yogurt with 3.2% of milk fat.
Consumers knowledge about dietary fibre — Results of a survey questionnaire in Hungary and Romania
Authors: Szűcs V. , Fazakas Z. , Tarcea M. , Guiné R.
Published: November 2016

Dietary fibres (DFs) are essential components of the balanced diet. Even though the adequate level of their consumption can be ensured from several natural (e.g. fruit, vegetables, legumes) and ‘artificial’ sources (e.g. functional foods), the consumed levels are below the recommendations. To analyse the Hungarian and Romanian consumers’ knowledge level, their perceptions of the health benefits associated with fibre, as well as the recognition of the potential information sources, a survey questionnaire was conducted with the total of 713 consumers. Results showed that the level of knowledge about DFs was not adequate. Internet was found to be widely used and identified as one of the most appropriate information sources to encourage the consumption of DF. It was a favourable result that three-quarter of the respondents was interested in the topic of healthy food consumption; however, just less than half of them took into consideration the label information during their shopping decisions. To increase the consumption of DF and to support the responsibility and conscious consumer decisions steps must to be done (e.g. education of children, pointing out of the sources). For this purpose, modern information technology and communication channels fitting to the consumers’ cultural and personal particularities can be utilized.
Quantification of Lactobacillus helveticus in a mixture of lactic acid bacteria using qPCR in cheese
Authors: Mühlhansová A. , Zhexenbay N. , Kozybayev A. , Horáčková Š. , Solichová K. , Plocková M.
Published: November 2016

Conventional quantification of L. helveticus, in presence of other lactobacilli species, using classical plate method employing low selective media is very inaccurate. Determination of L. helveticus using quantitative PCR (qPCR) was performed in six artisanal Kazakh soft cheeses made from cow’s milk or from a mixture of cow’s and goat’s milk. L. helveticus was quantified by species-specific qPCR, monitoring the presence of genes encoding for peptidoglycan hydrolases. Quantification of L. helveticus based on qPCR ranged from 2.6×106 to 4.1×108 CFU·g−1 according to the type of the cheese. The microflora of cheese consisted of a mixture of starter and non-starter lactic acid bacteria.
Variability of selected physicochemical characteristics of defrosted whiteleg shrimps (Litopenaeus vannamei) after culinary processing
Authors: Đorđević Đ. , Buchtová H.
Published: November 2016

The aim of the study was to estimate how selected physical and chemical characteristics of defrosted modified atmosphere packaged (MAP) not deveined shrimp (green shrimp with head) (Litopenaeus vannamei) meat are affected by two of the most often used culinary processing (cooking and frying). The experiment was carried out with 61 green shrimps with head (the country of origin: Ecuador; MAP 30% CO2/70% N2; stored 8 days at 0 °C to +2 °C) samples and evaluation of weight loss, pH, total volatile basic nitrogen (TVBN), and trimethylamine (TMA) contents. Weight losses and pH of examined shrimp samples after cooking and frying were significantly (P<0.05) lower, while same fluctuations in TVBN and TMA contents were noticed between culinary treatments (cooking, frying) as between different parts of shrimp tails. Significant correlations (P<0.05) were found between pH values and freshness indicators (TVBN, TMA-N), emphasizing different ongoing post-mortem metabolic and degradation processes in different parts of edible shrimp (Litopenaeus vannamei) parts (peeled tail).
A terminológiai munka szabványosításban betöltött szerepének vizsgálata egy kozmetikai szabvány példáján
Authors: Igaz Judit
Published: November 2016

A terminológiai munka hasznának vizsgálata nemcsak elméleti és tudományos, hanem gazdasági szempontból is lehetséges. A terminológiai tevékenység bevezetésének különösen nagy jelentősége van a szabványosítás terén, amely a gazdasági élet kiemelkedő fontosságú komponense. A tanulmány A terminológia és a szabványosítás kapcsolata című szakdolgozatom (2013) legfontosabb tanulságait mutatja be. A dolgozatban egy kozmetikai szabványt vizsgáltam terminológiai szempontból, és terminusaiból kétnyelvű terminológiai adatbázist készítettem.
A svájci jogi-közigazgatási terminológiai adatbank, a TermDat
Authors: Novák Barnabás , Tamás Dóra Mária
Published: November 2016

A tanulmány tárgyát képező svájci jogi-közigazgatási terminológiai adatbank alapjait még 1987-ben fektették le, jelentős múlttal rendelkező projektről van tehát szó. Az adatbankot mind a mai napig frissítik és használják, sőt, nemrég számottevő, felhasználóbarát újításokat is végrehajtottak rajta. A TermDat létrejöttének körülményeit, típusát, felépítésének adatmezőit ismertetjük a tanulmányban, mivel ezek az információk számos tanulsággal szolgálhatnak akár hazai terminológiai adatbázisok létrehozására. Sőt, az alaposabb megismerés elősegítésére az olvasó még a háttérben folyó terminológiai munkába is betekintést nyerhet.
A szótárkritika Magyarországon — szótárrecenziók bibliográfiája 1990–2010
Authors: Nagy Ilona
Published: November 2016

Jelen tanulmány központi témaköre a magyar szótárkritika 1990 és 2010 között. A szótári bibliográfia összeállításához tíz, Magyarországon megjelenő folyóirat anyagát használtam fel. A vizsgált folyóiratok: Alkalmazott Nyelvtudomány, Fordítástudomány, Iskolakultúra, Magyar Nyelv, Magyar Nyelvőr, Magyar Terminológia, Magyar Tudomány, Modern Nyelvoktatás, Nyelvtudományi Közlemények és THL2.
A hybrid adaptive controller based on sliding mode control and rbf neural network for variable speed wind turbine
Authors: El Mjabber El Kabira , El Hajjaji A. , Khamlichi A.
Published: November 2016

Considering the below rated power region of a variable speed wind turbine approximated by a single-degree-of-freedom system, a hybrid adaptive controller based on sliding mode control and radial basis functions neural networks was proposed. Stability of this controller was assessed by using Lyapunov approach. The control algorithm was implemented by means of Matlab/Simulink software package. Comparison with other reference controllers has proven that the proposed controller is relevant as it improves performance in terms of produced electrical energy by the wind turbine system while reducing the amplitude and fluctuations of mechanical loads.
Spectral and energy efficiency of massive MIMO system
Authors: Al-Rawi M. , Al-Rawi M.
Published: November 2016

This paper deals with the most recent technology in wireless communication which is massive multiple input multiple output system. The paper studies the performance of massive multiple input multiple output uplink system over Rayleigh fading channel. The performance is measured in terms of spectral and energy efficiency using three schemes of linear detection, maximum-ratio-combining, zero forcing receiver, and minimum mean-square error receiver. The simulation results show that the spectral and energy efficiency increases with increasing the number of base station antennas. Also, the spectral and energy efficiency with minimum mean-square error receiver is better than that withzero forcing receiver, and the latter is better than that with maximum-ratio-combining. Furthermore, the energy efficiency decreases with increasing the spectral efficiency.
Fault-tolerant PWM inverter model development for safety electrical drives
Authors: Szász Cs. , Şinca R.
Published: November 2016

This paper deals with the most recent technology in wireless communication which is massive multiple input multiple output system. The paper studies the performance of massive multiple input multiple output uplink system over Rayleigh fading channel. The performance is measured in terms of spectral and energy efficiency using three schemes of linear detection, maximum-ratio-combining, zero forcing receiver, and minimum mean-square error receiver. The simulation results show that the spectral and energy efficiency increases with increasing the number of base station antennas. Also, the spectral and energy efficiency with minimum mean-square error receiver is better than that withzero forcing receiver, and the latter is better than that with maximum-ratio-combining. Furthermore, the energy efficiency decreases with increasing the spectral efficiency.
Variational principles of continuum — to the memory of István Gyarmati
Authors: Horváth R.
Published: November 2016

The variational principle, which allows the deduction of the basic equation system of continuum mechanics from the local form of Gyarmati’s integral principle is presented in this paper. Following the approach of irreversible thermodynamics, the principle the kinetic energy is described like the fundamental equation of thermodynamics as the internal energy change, namely intensive quantity multiplied by the changing of extensive quantity. As the internal energy is objective so that is an independent quantity from the coordinate system, this description to the internal energy can be done. However, the kinetic energy is coordinate-dependent quantity. To resolve this contradiction the stress tensor can be divided into elastic and dissipative stress components by using the laws of thermodynamics.
Building constructions and structures part II. Structural changes in the framework of buildings
Authors: Lámer G.
Published: November 2016

Part II of the study deals with changes of support structures interpreted among building constructions. We primarily link structural changes to the application of new materials and new approaches. Two areas are dealt with in this present study. One is the development and change of vaults, the other is changes of framework of building in case of applying new materials that are only partly suitable for taking bending and tensile stress.
Vacuum insulation panels (VIPS) in building envelope constructions: An overview
Authors: Song K. , Mukhopadhyaya P.
Published: November 2016

Driven by updated building energy codes and green building initiatives across the world, vacuum insulation panel, also known as VIP, has become a desired insulation product for building envelope constructions. VIP has initial center-of-panel thermal conductivity of 0.004 W/mK or lower, and integration of VIP in building envelopes can reduce CO2 emissions and contribute towards ‘net-zero’ or ‘near-net-zero’ building constructions. Although VIPs have been applied in real-world constructions across the world, primarily in Asia, Europe and North America, it is still a novel building product under investigation. This overview paper is a summary of fundamentals, constituents, constructions and performances of VIPs. The paper shows there exists many advantages and challenges associated with the integration of VIPs in building envelope constructions. The speed at which VIPs will be integrated in building envelope construction in the coming years remains unclear; nevertheless, it is evident that vacuum technology is the promising way forward for sustainable building envelope constructions in the 21st century.
Effect of RpoN, RpoS and LuxS pathways on the biofilm formation and antibiotIc sensitivity of Borrelia burgdorferi
Authors: Sapi Eva , Theophilus Priyanka A. S. , Pham Truc V. , Burugu Divya , Luecke David F.
Published: November 2016

Borrelia burgdorferi, the causative agent of Lyme disease, is capable of forming biofilm in vivo and in vitro, a structure well known for its resistance to antimicrobial agents. For the formation of biofilm, signaling processes are required to communicate with the surrounding environment such as it was shown for the RpoN—RpoS alternative sigma factor and for the LuxS quorum-sensing pathways. Therefore, in this study, the wild-type B. burgdorferi and different mutant strains lacking RpoN, RpoS, and LuxS genes were studied for their growth characteristic and development of biofilm structures and markers as well as for their antibiotic sensitivity. Our results showed that all three mutants formed small, loosely formed aggregates, which expressed previously identified Borrelia biofilm markers such as alginate, extracellular DNA, and calcium. All three mutants had significantly different sensitivity to doxycyline in the early log phase spirochete cultures; however, in the biofilm rich stationary cultures, only LuxS mutant showed increased sensitivity to doxycyline compared to the wild-type strain. Our findings indicate that all three mutants have some effect on Borrelia biofilm, but the most dramatic effect was found with LuxS mutant, suggesting that the quorum-sensing pathway plays an important role of Borrelia biofilm formation and antibiotic sensitivity.
Comparative antibody responses against three antimalarial vaccine candidate antigens from urban and rural exposed individuals in Gabon
Authors: Imboumy-Limoukou Roméo-Karl , Oyegue-Liabagui Sandrine Lydie , Ndidi Stella , Pegha-Moukandja Irène , Kouna Charlene Lady , Galaway Francis , Florent Isabelle , Lekana-Douki Jean Bernard
Published: November 2016

The analysis of immune responses in diverse malaria endemic regions provides more information to understand the host’s immune response to Plasmodium falciparum. Several plasmodial antigens have been reported as targets of human immunity. PfAMA1 is one of most studied vaccine candidates; PfRH5 and Pf113 are new promising vaccine candidates. The aim of this study was to evaluate humoral response against these three antigens among children of Lastourville (rural area) and Franceville (urban area). Malaria was diagnosed using rapid diagnosis tests. Plasma samples were tested against these antigens by enzyme-linked immunosorbent assay (ELISA). We found that malaria prevalence was five times higher in the rural area than in the urban area (p < 0.0001). The anti-PfAMA1 and PfRh5 response levels were significantly higher in Lastourville than in Franceville (p < 0.0001; p = 0.005). The anti-AMA1 response was higher than the anti-Pf113 response, which in turn was higher than the anti-PfRh5 response in both sites. Anti-PfAMA1 levels were significantly higher in infected children than those in uninfected children (p = 0.001) in Franceville. Anti-Pf113 and anti-PfRh5 antibody levels were lowest in children presenting severe malarial anemia. These three antigens are targets of immunity in Gabon. Further studies on the role of Pf113 in antimalarial protection against severe anemia are needed.
Using linguistic methods in clinical communication education
Authors: Li Shuangyu , Said Fatma , O'Neill Bernadette , Ancarno Clyde , Niksic Maja
Published: November 2016

This article was migrated. The article was marked as recommended. Introduction:Analysis and reflection are important components of clinical communication learning in undergraduate medical education. Current medical consultation models do not provide an effective means to analyze interaction during consultations, compromising a conversational approach to consultations. This paper introduces a conversational analytic framework: The Clin-Com Tool (CCT), drawing on interactional linguistics.Methods: 17 medical students and six communication tutors took part in an educational intervention. A mixed-methods evaluation was conducted to compare 1) participants' abilities to analyze consultations pre- and post-intervention, and 2) elicit their perspectives of learning and using the CCT.Results: The findings showed an improvement in participants' analytic skills in the post-intervention test (p<0.044, 95% Confidence Interval). Participants felt that the CCT heightened awareness of interactional features and socio-cultural effects on communication, and provided a systematic approach to analysis using a set of common language.Conclusion:The CCT emphasizes the development of students' critical ability to judge and act upon the constantly changing interactional communicative situations. It transforms intuitive feelings into systematic and evidence-based analysis of interaction, enabling the development of more strategic and conversational communication with patients. The Tool can become a useful addition to other communication and consultation models used in undergraduate medial education.
Integrating Basic Sciences in the Medical Laboratory Sciences Curriculum: A Case Study of Strategies and Approaches
Authors: Jones Taggart Holly , Sanchez Otto
Published: November 2016

This article was migrated. The article was marked as recommended. The Medical Laboratory Sciences profession in Canada is undergoing a transformation in education whereby students can now earn an undergraduate degree alongside a professional technologist's certification. To accomplish both goals, the undergraduate program must focus simultaneously on the performance of clinical diagnostic testing in the laboratory and the underlying basic science principles and mechanisms. This paper is a reflective analysis of the strategies and approaches to enhance student exposure to foundational science in the context of the competency profile for the profession. We also share our guiding principles in course design and delivery, as well as our lessons learned. In conclusion, each course delivered within the program must take a coordinated approach to underscore integration of basic science into clinical concepts to most effectively enhance clinical knowledge and skills.
Targeting the KRAS Pathway in Non-Small Cell Lung Cancer
Authors: Tomasini Pascale , Walia Preet , Labbe Catherine , Jao Kevin , Leighl Natasha B.
Published: November 2016

Lung cancer remains the leading cause of cancer-related deaths worldwide. However, significant progress has been made individualizing therapy based on molecular aberrations (e.g., EGFR, ALK) and pathologic subtype. KRAS is one of the most frequently mutated genes in non-small cell lung cancer (NSCLC), found in approximately 30% of lung adenocarcinomas, and is thus an appealing target for new therapies. Although no targeted therapy has yet been approved for the treatment of KRAS-mutant NSCLC, there are multiple potential therapeutic approaches. These may include direct inhibition of KRAS protein, inhibition of KRAS regulators, alteration of KRAS membrane localization, and inhibition of effector molecules downstream of mutant KRAS. This article provides an overview of the KRAS pathway in lung cancer and related therapeutic strategies under investigation.
Sunitinib: Ten Years of Successful Clinical Use and Study in Advanced Renal Cell Carcinoma
Authors: Motzer Robert J. , Escudier Bernard , Gannon Andrew , Figlin Robert A.
Published: November 2016

The oral multikinase inhibitor sunitinib malate was approved by the U.S. Food and Drug Administration in January 2006 for use in patients with advanced renal cell carcinoma (RCC). Since then, it has been approved globally for this indication and for patients with imatinib-resistant or -intolerant gastrointestinal stromal tumors and advanced pancreatic neuroendocrine tumors. As we mark the 10-year anniversary of the beginning of the era of targeted therapy, and specifically the approval of sunitinib, it is worthwhile to highlight the progress that has been made in advanced RCC as it relates to the study of sunitinib. We present the key trials and data for sunitinib that established it as a reference standard of care for first-line advanced RCC therapy and, along with other targeted agents, significantly altered the treatment landscape in RCC. Moreover, we discuss the research with sunitinib that has sought to refine its role via patient selection and prognostic markers, improve dosing and adverse event management, and identify predictive efficacy biomarkers, plus the extent to which this research has contributed to the overall understanding and management of RCC. We also explore the key learnings regarding study design and data interpretation from the sunitinib studies and how these findings and the sunitinib development program, in general, can be a model for successful development of other agents. Finally, ongoing research into the continued and future role of sunitinib in RCC management is discussed.
In Reply
Authors: Brandi Giovanni , Deserti Marzia , Vasuri Francesco , Farioli Andrea , Degiovanni Alessio , Palloni Andrea , Frega Giorgio , Barbera Maria A. , de Lorenzo Stefania , Garajova Ingrid , Di Marco Mariacristina , Pinna Antonio D. , Cescon Matteo , Cucchetti Alessandro , Ercolani Giorgio , D’Errico-Grigioni Antonietta , Pantaleo Maria A. , Biasco Guido , Tavolari Simona
Published: November 2016

Brandi et al. clarify data about the localization of human equilibrative nucleoside transporter 1 in cancer patients receiving gemcitabine-based chemotherapy. They discuss methodology, differences between antibodies, and recommendations for further study.
Adolfo Bioy Casares e Mario Bellatin: sobre cartas sem corpo e falésias
Authors: Fernandes Cipreste Karla
Published: November 2016

Propõe-se uma leitura de dois escritores hispano-americanos – Adolfo Bioy Casares e Mario Bellatin – com o propósito de refletir sobre discursos de poder, incluído o âmbito da Crítica Latino-americana. Entendem-se as experiências dos personagens de suas obras, e também o ethos de ambos os autores, como uma existência ética e estética que resiste às tentativas de categorizações. A proposta se faz à luz do conceito de Comunidade, do filósofo italiano Roberto Esposito, e da discussão de Hugo Achugar sobre o local e o global na América Latina. Duas imagens inspiram essa análise: a carta sem corpo em Dormir al sol, de Casares; e a falésia de Bellatin em Los fantasmas del masajista.
Compreensão (con)textual em mídias sociais digitais
Authors: Barros Demétrio Alana Kercia , Pereira Alves Luiz Eleildo , Araújo Costa Maria Helenice
Published: November 2016

Neste artigo, abordamos a questão da leitura sob o ponto de vista da complexidade. Considerando com Beaugrande (1997) que o texto é um evento comunicativo cuja configuração envolve elementos de diferentes naturezas, incluindo os participantes da interação, entendemos que as abordagens tradicionais da leitura, mesmo as que se voltam para a interação, não amparam satisfatoriamente a compreensão do fenômeno. Com o intuito analisar de que modo aspectos que caracterizam a leitura como atividade complexa se manifestam na compreensão (con)textual em mídias sociais digitais, apoiamo-nos nos trabalhos de Pellanda (2005) e de Franco (2011) e tomamos por base a teoria autopoiética de Maturana e Varela (1995), bem como as noções de emergência e incorporação de Hanks (2008). Por meio da análise de dois exemplos de interação veiculados em ambiente virtual, observamos que a leitura desencadeia a autopoiese dos leitores enquanto sistemas vivos.

Palavras-chave: Linguagem. Complexidade. Autopoiese. Leitura. Emergência. Incorporação.
A study on patients treated with interlock nailing in the forearm fracture bones
Authors: G. V. Shivakumar , P. R. Naveen , M. L. Manjunatha
Published: November 2016

Background: Fractures involving the bones of the forearm present unique problems not encountered with fractures of other long bones and may significantly affect the function of the upper limb. The purpose of the present study was to evaluate the functional outcome of patients treated with interlock nailing in the fracture forearm bones.

Methods: Thirty two patients included after their consent. With the patient supine on a radiolucent table, and under general or regional anesthesia the extremity was prepared and the surgery was performed using a standard procedure. If secure rigid fixation is achieved forearm POP splint is applied and kept in place for 2 weeks, thereafter a removable sugar-tong orthosis is worn until bridging callus is present, and the orthosis is removed frequently for exercise.

Results: The average age of the patients was 38.90 years. The major mode of injury was RTA (59.09%) followed by assault (36.36%). 41% of patients were operated within week of injury, only three patients were operated after a week and one patient after 3 weeks. More than half of patients had closed fractures and rest was open fractures, of which Gustilo Anderson type II were in majority. In 3/5 of patients locking at nondriving end was not done cause of stable fixation. There was statistically significant difference in the surgical time (P <0.05) and duration of postoperative immobilization differed statistically significantly (P <0.001) between the group of patients in whom locking was done and not done.

Conclusions: Advantages of Interlocking nail are high rate of bony consolidation along with minimized surgical approaches, cosmetically better suited and little risk of refracture after removal of the implant.
Study of oxidative stress in patients of psoriasis
Authors: Kaur Manpreet , Sharma Saurabh , Kukreja Sahiba , Kaur Jasleen , Bassi Roopam
Published: November 2016

Background: Psoriasis is a well-recognized chronic inflammatory papulosquamous disorder characterized by the formation of salmon colored papules and plaques with silvery white scales. The aim of this study was to do a comparative evaluation of the parameters of oxidative stress, namely glutathione peroxidase, malondialdehyde and superoxide dismutase in patients of psoriasis with normal healthy subjects

Methods: 60 subjects in the age group of 30-70 years were included in the study; Group A consisted of 30 newly diagnosed psoriasis patients presenting to the Dermatology OPD and Group B consisted of 30 normal healthy individuals. Thorough history taking and clinical examination were done. The punch biopsy was performed for histopathological examination and markers of oxidative stress were measured in each case and these values were then compared to healthy controls and statistical analysis was performed.

Results: On comparison of the two groups, the levels of anti-oxidants superoxide dismutase and glutathione peroxidase were found to be decreased in psoriasis patients (168.46±51.89 U/ml and 4121.63±1812.53 U/ml respectively) as compared to controls (237±39.30 U/ml and 8435±1397.54 U/ml respectively) which was statistically highly significant (p <0.001) and the level of pro-oxidant malondialdehyde was found to be increased in patients of psoriasis (0.42±0.13 nmol/ml) in contrast to controls (0.08±0.06 nmol/ml)which was also statistically highly significant (p <0.001).

Conclusions: Keeping in consideration the increased oxidative stress in the patients of psoriasis, the anti-oxidant drugs can form an important part of the therapeutic ladder of psoriasis. 