bluuebunny/crossref_metadata_2025 huggingface dataset:
A Predictive Model of Vaccine Reactogenicity Using Data from an In Vitro Human Innate Immunity Assay System
Authors: Pullen Robert H , Sassano Emily , Agrawal Pankaj , Escobar John , Chehtane Mounir , Schanen Brian , Drake Donald R , Luna Ernesto , Brennan Richard J
Published: January 2024

A primary concern in vaccine development is safety, particularly avoiding an excessive immune reaction in an otherwise healthy individual. An accurate prediction of vaccine reactogenicity using in vitro assays and computational models would facilitate screening and prioritization of novel candidates early in the vaccine development process. Using the modular in vitro immune construct model of human innate immunity, PBMCs from 40 healthy donors were treated with 10 different vaccines of varying reactogenicity profiles and then cell culture supernatants were analyzed via flow cytometry and a multichemokine/cytokine assay. Differential response profiles of innate activity and cell viability were observed in the system. In parallel, an extensive adverse event (AE) dataset for the vaccines was assembled from clinical trial data. A novel reactogenicity scoring framework accounting for the frequency and severity of local and systemic AEs was applied to the clinical data, and a machine learning approach was employed to predict the incidence of clinical AEs from the in vitro assay data. Biomarker analysis suggested that the relative levels of IL-1B, IL-6, IL-10, and CCL4 have higher predictive importance for AE risk. Predictive models were developed for local reactogenicity, systemic reactogenicity, and specific individual AEs. A forward-validation study was performed with a vaccine not used in model development, Trumenba (meningococcal group B vaccine). The clinically observed Trumenba local and systemic reactogenicity fell on the 26th and 93rd percentiles of the ranges predicted by the respective models. Models predicting specific AEs were less accurate. Our study presents a useful framework for the further development of vaccine reactogenicity predictive models.
Synchronous multiple neuroendocrine primary lung cancer with endobronchial extension in a never smoker - An unusual manifestation
Authors: V Vinay , Munjal Sushil Kumar , Saini Jitendra Kumar , Singh Gaurav Kumar , Modi Shibani , Srivastava Alpana
Published: January 2024

Synchronous Lung Cancer primaries (SLC) are uncommon, with diverse underlying histology, constituting only a small proportion. The scarcity also poses a challenge in formulating a standardized diagnostic approach. Consequently, the diagnostic and staging challenges for SLC are heightened, particularly when the tumors are located on opposite sides of the chest. We report an exceptionally rare phenomenon in synchronous multiple primary lung cancers with simultaneous occurrence of two neuroendocrine tumors with endobronchial extension, small cell carcinoma and typical carcinoid tumor. Immunohistochemistry proved valuable in confirming the diagnosis. Given the poor prognosis associated with such cases, an accurate diagnosis is crucial for determining appropriate treatment options.
Eating vegetables is not always a good advice. A case report and literature review of acquired methemoglobinemia
Authors: Vercelli Andrea , Nasone Irene , Pagani Laura , Dacrema Alessandro , Veneziani Alberto , Agosti Antonio , Poggiali Erika
Published: January 2024

Methemoglobinemia (MET) is a life-threatening condition resulting from the development of methemoglobin (MetHb), which binds oxygen irreversibly, causing refractory hypoxia and so-called “functional anemia”. MET can be caused by hereditary or acquired processes. Acquired forms are the most common. Symptoms correlate with the MetHb level and range from cyanosis and dyspnea to dysrhythmias, metabolic acidosis, coma, and cardiac arrest. MetHb levels above 70% are fatal. Methylene blue (MB) is the specific antidote. In all cases, supportive treatment, including intravenous hydration, glucose correction, and oxygen supplementation, must be started immediately. Exchange transfusion has been used successfully to treat MET and may be appropriate in patients for whom MB is ineffective. We report the case of a 54-year-old woman who presented to our emergency department for the acute and sudden development of chest pain, shortness of breath, and severe cyanosis after drinking a significant amount of boiled courgette water. Arterial blood gas analysis revealed a MetHb level of 26%. She was treated immediately with MB, oxygen supplementation, and hydration with normalization of her MetHb in 12 hours. Our recommendation is to always investigate MET in patients with unexplained cyanosis and refractory hypoxia.
Assessment of adoption of Global GAP standard: Evidences from Fruit and Vegetable farmers
Authors: Hussain Syed Raza , Zahid Rashid Muhammad , Haidri Irfan , Shafqat Usman , Mahmood Faisal
Published: January 2024

Food safety certifications, such as the Global Good Agricultural practices standard (GGAP), are mandatory for export. This research was conducted as a baseline to study the suitability of this standard in the generic conditions of Pakistan. A questionnaire was prepared based on the Fruit and Vegetable (F&V) module of GGAP. Based on annual turnover, five (5) groups were designed comprising fifteen (15) farmers. Results revealed that the clauses related to simple paperwork were found implementable. However, clauses that needed capital investment and technical records, etc., were declared as not implementable. Results also revealed that a significant number of farmers favoured declaring risk assessment, training, and documents as implementable. Results of record keeping, installation, visual presentation, and infrastructure showed that 42-56% of clauses were implementable. Moreover, in the case of external testing, health safety, and hygiene, 24-37 % of clauses were found to be not implementable. So, based on the results, it can be concluded that a major number of the Global GAP standard clauses were found unsuitable or not implementable in the generic conditions of Pakistan, and there is a dire need to harmonize clauses to create local standards.
Real-World Treatment Patterns according to Clinical Practice Guidelines in Patients with Type 2 Diabetes Mellitus and Established Cardiovascular Disease in Korea: Multicenter, Retrospective, Observational Study
Authors: Yang Ye Seul , Kim Nam Hoon , Baek Jong Ha , Ko Seung-Hyun , Son Jang Won , Lee Seung-Hwan , Rhee Sang Youl , Kim Soo-Kyung , Sohn Tae Seo , Jun Ji Eun , Jeong In-Kyung , Kim Chong Hwa , Song Keeho , Rhee Eun-Jung , Noh Junghyun , Hur Kyu Yeon ,   Committee of Clinical Practice Guidelines, Korean Diabetes Association
Published: January 2024

Background: Recent diabetes management guidelines recommend that sodium-glucose cotransporter 2 inhibitors (SGLT2is) or glucagon-like peptide 1 receptor agonists (GLP-1RAs) with proven cardiovascular benefits should be prioritized for combination therapy in patients with type 2 diabetes mellitus (T2DM) and established cardiovascular disease (CVD). This study was aimed at evaluating SGLT2i or GLP-1RA usage rates and various related factors in patients with T2DM and established CVD.Methods: We enrolled adults with T2DM aged ≥30 years who were hospitalized due to established CVD from January 2019 to May 2020 at 13 secondary and tertiary hospitals in Korea in this retrospective observational study.Results: Overall, 2,050 patients were eligible for analysis among 2,107 enrolled patients. The mean patient age, diabetes duration, and glycosylated hemoglobin level were 70.0 years, 12.0 years, and 7.5%, respectively. During the mean follow-up duration of 9.7 months, 25.7% of the patients were prescribed SGLT2is after CVD events. However, only 1.8% were prescribed GLP-1RAs. Compared with SGLT2i non-users, SGLT2i users were more frequently male and obese. Furthermore, they had a shorter diabetes duration but showed worse glycemic control and better renal function at the time of the event. GLP-1RA users had a longer duration of diabetes and worse glycemic control at the time of the event than GLP-1RA non-users.Conclusion: The SGLT2i or GLP-1RA prescription rates were suboptimal in patients with T2DM and established CVD. Sex, body mass index, diabetes duration, glycemic control, and renal function were associated with the use of these agents.
Scleral collagen cross linkage in progressive myopia
Authors: Yasir Ziaul H , Sharma Rakesh , Zakir Shaik M
Published: January 2024

High myopia is often associated with local ectasia and scleral thinning. The progression of myopia depends upon scleral biochemical and biomechanical properties. Scleral thinning is associated with decreased collagen fiber diameter, defective collagen fibrillogenesis, and collagen cross-linking. Reversing these abnormalities may make the sclera tougher and might serve as a treatment option for myopic progression. Collagen cross-linking is a natural process in the cornea and sclera, which makes the structure stiff. Exogenous collagen cross-linkage is artificially induced with the help of external mediators by using light and dark methods. In this systematic review, we discussed existing literature available on the internet on current evidence-based applications of scleral collagen cross-linking (SXL) by using different interventions. In addition, we compared them in tabular form in terms of their technique, mechanisms, cytotoxicity, and the stage of transition from preclinical to clinical development. Furthermore, we discussed the in-vivo technique to evaluate the post-SXL scleral biomechanical property and outcome in the human eye.
Ionospheric equivalent slab thickness ingestion into the NeQuick model
Authors: Pignalberi Alessio , Nava Bruno , Pietrella Marco , Pezzopane Michael , Coïsson Pierdavide , Cesaroni Claudio
Published: January 2024

The ionospheric equivalent slab thickness (τ), defined as the ratio of the vertical total electron content (vTEC) to the ionospheric F2-layer electron density maximum (NmF2), is a parameter providing useful information on the shape of the vertical electron density profile. However, the use of this information is of difficult practical application in empirical ionosphere models, such as the NeQuick model, because by design they do not explicitly include τ as a modelling parameter. In this work, we investigated the opportunity of using measured τ values to improve the empirical modelling of the ionosphere vertical electron density profile by NeQuick. Measured τ values were obtained through NmF2 observations and vTEC measurements obtained between 2001 and 2019 by an ionosonde and a ground-based GNSS receiver, respectively, co-located at Rome ionospheric station (41.8° N, 12.5° E; Italy). NeQuick τ was obtained as the ratio between modelled NmF2 and vTEC values, the latter obtained by integration of the vertical profile. As a first step, τ values modelled by NeQuick were compared with corresponding values measured at Rome station to highlight diurnal, seasonal, and solar activity differences. Then, measured τ values were ingested in NeQuick through a three-parameter assimilation procedure which first assimilate F2-layer peak characteristics to constrain the F2-layer anchor point, and then assimilate vTEC to optimize the F2-layer shape through the NeQuick F2-layer thickness parameter, namely B2bot. The assimilation procedure provides information on how the NeQuick B2bot has to be modified to match measured τ values, and then on how the shape of the F2-layer profile has to be changed accordingly. Our results highlight that, in many cases, the NeQuick B2bot has to be increased to match observations, which has implications on the modelling of the NeQuick bottomside and topside effective scale heights.
Universidades en movimiento. Una experiencia Cubana
Authors: Romero Díaz Celia
Published: January 2024

En relación con la práctica de actividades propias de la Cultura Física las universidades cubanas tienen vasta experiencia que, con los años se ha seguido perfeccionando. Muchas iniciativas y alternativas se han gestado para incorporar a la mayor cantidad de educandos a la práctica masiva del deporte y otras variedades físico-recreativas, así como a la Educación Física. Todo ello contribuye al desarrollo integral de los estudiantes, así como a la mejora de su salud integral, por lo que debe garantizarse dicha actividad en la comunidad universitaria. Ha sido intención de la autora confirmar la importancia que tiene la Cultura Física en las Casas de Altos Estudios, particularmente en la Universidad Agraria donde presto servicios como profesional.
PROGRAMA DIDÁCTICO APRENDIZAJE COLABORATIVO Y LOGRO DE APRENDIZAJE EN ESTUDIANTES DE ESTADÍSTICA
Authors: Alva Morales Jenny , Rodríguez Azabache Julio Antonio
Published: January 2024

El presente estudio tiene como fin determinar de qué manera el programa basado en el aprendizaje colaborativo influye en el logro del aprendizaje de los estudiantes del curso de estadística, el enfoque de la investigación es cuantitativa, de tipo aplicado explicativo y diseño preexperimental, la muestra estuvo conformada por 46 estudiantes del curso de estadística de la Facultad de Ciencias Administrativas y Económicas de una universidad privada en la ciudad de Trujillo en el año 2019, se aplicó una prueba de rendimiento académico antes y después de la aplicación del programa didáctico. Se hallaron diferencias altamente significativas y variaciones en los logros de aprendizaje del curso de estadística con relación a la puntuación final y a la puntuación inicial, se concluye que el programa basado en el aprendizaje colaborativo influye en el logro del aprendizaje de los estudiantes del curso de estadística.
Sustainable Development in Management Thinking: Past Contributions, Present Challenges and Future Directions
Authors: Briseño-García Arturo , Zorrilla-delCastillo Ana Luz , Azuela-Flores Cristabell
Published: January 2024

The aim of this paper is to present the main arguments around the concept of sustainable development as a business perspective and the influence that this concept has brought to firms and their operations. It explains relevant literature on sustainable development describing its foundations, their current challenges and some of the future directions along which the concept can achieve its intended purpose. The arguments suggest that before calling for a massive green campaign in business, there are unresolved issues around the concept of sustainable development, there is a particular need to understand the real motivation of firms for sustainable. For example, at the industry level, a firm’s behavior is a complex issue to control – either through pre-established legal parameters or through a voluntary approach. The interest in sustainable practices has created important implications for managers in almost every industry looking to better understand the arguments around the concept of sustainable development and the commitment that firms should make to address these environmental challenges. Research centered only on economic benefits or only on environmental issues can lead to an incomplete vision of the opportunities for firms that both approaches can generate if they are correctly combined.
La transición agroecológica de los pequeños productores de huertos familiares
Authors: Castellanos-Guzmán Diana , Toledo-López Arcelia , Guzmán-Cruz Dora Lilia
Published: January 2024

En este trabajo se describe el proceso de investigación acción participativa (IAP) en la comunidad de Cuilápam de Guerrero, Oaxaca, en un contexto de confinamiento causado por la pandemia de covid-19 (2021), situación que motivó el interés por la actividad agrícola y de traspatio en algunos habitantes. El objetivo de esta investigación fue generar alternativas agroalimentarias, a través de huertos familiares agroecológicos, para reducir la inseguridad alimentaria de las familias de pequeños productores agrícolas de subsistencia.

Se integró un grupo solidario de 10 participantes de 7 Unidades de Producción Familiar (UPF), interesados en la transición agroecológica para producir alimentos más sanos y saludables. Siguiendo la metodología IAP, se identificaron las necesidades de capacitación y se programaron los talleres con enfoque agroecológico. A través de este proceso, los participantes obtuvieron nuevos conocimientos para la práctica agrícola, intercambiaron saberes y establecieron valores dentro del grupo de trabajo como, la solidaridad, ayuda mutua, cooperación, reciprocidad y compromiso con el entorno.
Influencia de Género en la Brecha Salarial: Estudio del Mercado de Latacunga en los periodos 2010-2020
Authors: Parreño Herrera Carlos Alberto , Parreño Rivera Mauricio Sebastián
Published: January 2024

El artículo propuesto investiga cómo la brecha salarial de género ha afectado el mercado laboral en Latacunga, Ecuador entre los años 2010 y 2020. Se ha utilizado métodos deductivos e históricos para analizar datos estadísticos de la Encuesta Nacional De Empleo Desempleo y Subempleo (ENEMDU). El modelo para el análisis de datos fue el Oaxaca Blinder. El estudio se concentra en el impacto de la discriminación de género en los salarios y cómo factores como la educación y el número de hijos influyen en esta brecha. Los resultados indican una discriminación salarial persistente hacia las mujeres, sugiriendo que mientras los hombres se vuelven más activos en el mercado laboral, sus ingresos aumentan en comparación con las mujeres. Este estudio contribuye a la comprensión de las dinámicas de género en el mercado laboral y propone futuras investigaciones para abordar estas disparidades.
A Combination Intervention Of Conventional Educational Models And Motivational Interviews Increased Knowledge Of Dental And Oral Health And Reduced Dental Hygiene Index, Dental Care Index, And Gingiva Index In Primary School Children In Tomohon City, Nort
Authors: Mariati Ni Wayan , Duarsa Dyah Pradnyaparamita , Pinatih Gde Ngurah Indraguna
Published: January 2024

His experimental community trial investigates the impact of combining Conventional Education and Motivational Interviewing (CE-MI) models on oral health knowledge and indices among elementary school children in Tomohon City. A pretest and posttest control group design involved 106 randomly assigned respondents. The intervention group received the CE-MI model, while the control group had no intervention. Results revealed a significant increase in oral health knowledge in both groups. The control group showed a 5.02±1.01 knowledge score increase (p < 0.05), and the intervention group exhibited a substantial increase of 11.71±3.11 (p < 0.05). Furthermore, both groups experienced a decrease in dental hygiene index (OHI-S), with the control group decreasing by 3.50±1.07 (p < 0.05) and the intervention group by 4.13±2.30 (p < 0.05). Similarly, a reduction in dental caries index (DMF-T) was observed, with the control group decreasing by 2.84±1.21 (p < 0.05) and the intervention group by 4.13±2.30 (p < 0.05). The dental gingival index (GI) also fell in both groups, with the control group showing a reduction of 0.04±0.01 (p < 0.05) and the intervention group a decrease of 0.91±0.06 (p < 0.05). In conclusion, the CE-MI model intervention effectively enhances oral health knowledge and reduces dental indices in 5th and 6th-grade elementary school children in Tomohon City.
Biomodelado de los componentes del oído medio humano haciendo uso de imágenes de resonancia magnética
Authors: López-Liévano Adolfo , López-Liévano Daniel Ramón , Caicedo-Ortiz Hernando Efraín , González-Rebattú Alejandro , González-Rebattú Mauricio
Published: January 2024

En este trabajo se realiza el biomodelado de los elementos que componen el oído medio, el cual incluye el sistema tímpano-cadena oscicular (martillo, yunque y estribo) así como los ligamentos: anterior maleal, superior maleal e incudal posterior y, por último, las juntas o articulaciones incudomaleal e incudo-estapedial. Un aspecto de suma importancia en cuanto al desarrollo de modelos en elementos finitos, es sin duda, la exactitud de la geometría que se pretenda analizar respecto al modelo real, más aun si se trata de modelar los diferentes mecanismos y partes del cuerpo humano; es por tal motivo que en este trabajo se realiza una metodología de biomodelado, el cual toma como punto de partida la obtención de imágenes de una resonancia magnética del oído medio, posteriormente, por medio de diferentes softwares de diseño (Solidworks), así como de reconstrucción de imágenes (IrfanView, ScanIP) se genera el modelo solido virtual y, también, se aplican filtros para refinar o eliminar imperfecciones propias del biomodelado. Por último, el biomodelo se valida con datos geométricos de trabajos publicados en la literatura abierta. A este respecto, se constató que el presente modelo tiene una variación de alrededor del 21% respecto a los datos consultados en la literatura; sin embargo, se sabe que la anatomía del oído humano varía de acuerdo al género, al fenotipo y a la edad. En conclusión, este trabajo aporta un modelo del oído medio bastante fiel, que sirve como la base para modelar diferentes patologías con relativa facilidad, aportando así información vital al campo de la medicina.
Diseño, implementación y control para un banco de pruebas con bombas centrífugas en conexión serie y paralelo
Authors: Amores-Silva Ivette , Chávez-Estrada Miriam , Miranda-Ramos Mónica
Published: January 2024

El presente artículo muestra un banco de pruebas desarrollado e instalado en la Escuela Superior Politécnica en el Laboratorio de Operaciones Unitarias ESPOL con el objetivo de demostrar a través de la experimentación a los estudiantes de Ingeniería Química la forma en que deben ser operadas las bombas, tanto en paralelo como en serie, infiriendo sus diferentes conclusiones para cada caso. Para lograr este objetivo se ha realizado la implementación y luego la recopilación de datos que aportó al desarrollo del software SCADA en Labview, que permite ingresar el caudal y automáticamente a través de la programación obtener la presión, este proyecto fue concebido desde su diseño, estructura, tanto metalmecánica como eléctrica y electrónica, además de poseer su propio panel de control y programación. La metodología utilizada en este proyecto es experimental e inductiva; experimental debido a que parte de su diseño estructural, implementación hidráulica, eléctrica y electrónica, hace posible el accionamiento por medio del panel de control o desde el software; inductiva porque a través de los resultados inferidos por medio de las prácticas en el banco de pruebas, se ha podido conseguir datos que favorecen la optimización del sistema.
El chorro en toberllino y los vórtices de punta de ala
Authors: Fernández-Roque Tiburcio , Correa-Arredondo José Arturo , Vázquez-Flores José Félix , Sandoval-Lezama Jorge , Mejía-Carmona Alejandro
Published: January 2024

Los vórtices de punta de ala representan un riesgo para las aeronaves que vuelan detrás de otra por lo que el estudio de los mismos es necesario para prevenir accidentes aéreos al establecer las distancias mínimas que deben separar una aeronave de otra, sobre todo en las operaciones de despegue y aterrizaje de las mismas. Con el fin de analizar el comportamiento de los vórtices de punta de ala de una manera poco costosa y con la instrumentación disponible, en la Escuela Superior de Ingeniería Mecánica y Eléctrica Unidad Ticomán del Instituto Politécnico Nacional (México) se ha propuesto una línea de investigación sobre chorros y flujos en torbellinos con la hipótesis de que estos tienen una gran semejanza con los vórtices de punta de ala. Para el desarrollo de esta línea de investigación se construyó un equipo para generar el chorro en torbellino y se han utilizado diversos anemómetros; en este trabajo se presentan las mediciones realizadas sobre un chorro en torbellino de baja velocidad empleando un sensor de siete orificios. Se muestran los perfiles de velocidad tangencial y de velocidad axial, encontrándose que el comportamiento de ambas velocidades tiene una gran semejanza con los vórtices de punta de ala sobre todo con respecto al núcleo del vórtice.
El Proyecto Aula, metodología para el desarrollo de competencias profesionales
Authors: Zepeda-Hurtado María Elena , Campos-Monroy Laura , Cuéllar-Orozco Maricela
Published: January 2024

El caso de investigación que se analiza en este artículo fue llevado a cabo en el Nivel Medio Superior del Instituto Politécnico Nacional de México, en el Centro de Estudios Científicos y Tecnológicos 11, "Wilfrido Massieu", se basa en la implementación del "Proyecto Aula", que consiste en llevar a la práctica las metodologías de modelos educativos actuales: aprendizaje basado en problemas y aprendizaje colaborativo para el desarrollo de competencias genéricas, disciplinares y profesionales de las carreras de físico-matemáticas. Para documentar esta investigación-acción, se emplearon diferentes técnicas e instrumentos: observación, encuesta y entrevista de la población involucrada. El resultado es la generación de conocimientos en el amplio sentido, teóricos, actitudinales y procedimentales, es decir, en el desarrollo de competencias, a través de la elección y delimitación del tema: sustentabilidad.
Assessment of CAR and GIDS Methods to Interpolate Rain Values in Mexico City in Flood Event
Authors: Orozco-Aceves Gonzalo , Alcántara-Montes Samuel , Velázquez-Arcos Juan Manuel
Published: January 2024

Previous works regarding interpolated values in Mexico City has been carried out so far using Kringing in its different forms: OK, KED, UK, etc. The interpolation was used to estimate monthly average or to map the rain or temperature in Mexico to help agriculture. In this work an assessment is presented to observe the performance of two relatively new methods: CAR and GIDS. Furthermore, the assessment is made to observe the performance of rain values in Flood event in Mexico City. The values of September 29th 1976 were used and accuracy of the interpolators was measure through cross validation. The results are tabulated and analyzed.
Metodología combinada del uso de MarPrime y Vibrotip para diagnóstico del motor HYUNDAI HIMSEN 9H25/33
Authors: Oropesa-Márquez Yovany , Cecilia-Simón Nilo
Published: January 2024

En los motores de combustión interna (MCI) las vibraciones debidas al desbalance másico tienen dos fuentes reconocidas para el mecanismo reciprocante biela-manivela-corredera; una por los efectos de la inercia de las partes móviles y otra por la fluctuación en la presión de los gases en la cámara de combustión. El presente trabajo pretende mostrar una metodología para interpretar los resultados en la medición de la presión en los cilindros de un MCI traduciéndolos a un esquema de fluctuación compatible y comparable con el análisis de vibraciones realizado sobre el mismo equipo, con el objetivo de unificar ambos criterios e incrementar la confiabilidad del diagnóstico que se realiza con orientación al mantenimiento predictivo y explotación del motor. El equipo en cuestión es un motor HYUNDAI HIMSEN 9H25/33 de nueve cilindros en línea, empleado en los grupos electrógenos de 25 MW para generación distribuida y perteneciente a la Empresa de Mantenimiento a Grupos Electrógenos de Fuel Oil (EMGEF) en Pinar del Río, Cuba. Las mediciones y gráficos sobre la presión de los gases se realizaron con ayuda de MarPrime, mientras el análisis de vibraciones se realizó con base en los datos obtenidos por Vibrotip. La valoración de la efectividad del método se basa en la comparación con lo establecido en las normas ISO 10816 y 10816-3, teniendo además en cuenta su impacto en la economía de la empresa y en la disponibilidad de equipos para la generación.
Mecanismo de ação do canabidiol em processos neurodegenerativos associados ao envelhecimento: uma revisão integrativa
Authors: Gavioli Aline , Cadeu Ana Beatriz , Laurentino Gilberto , Ortiz Sandra Regina Mota
Published: January 2024

A Doença de Alzheimer é caracterizada pelo acúmulo de placas de β-amiloide, uma possível administração de canabidiol pode diminuir o acúmulo de placas de β-amiloide e pode melhorar a neuroplasticidade durante o envelhecimento. O canabidiol extraído da Cannabis sativa surgiu como uma possível estratégia interagindo com os astrócitos, diminuindo as funções pró-inflamatórias e estudando a morte celular neuronal induzida pelo β-amiloide, devido à sua capacidade de eliminar espécies reativas de oxigênio e reduzir a peroxidação lipídica, o que diminui o processo de neurodegeneração, sendo particularmente interessante quando se considera o envelhecimento do sistema nervoso, uma importante alteração grave da neurodegeneração, presente em doenças como a Doença de Parkinson e a Doença de Alzheimer. Diante dessa possível forma de tratamento, o presente estudo teve como objetivo verificar os mecanismos que o canabidiol leva à neuroplasticidade na doença de Alzheimer. Esta revisão integrativa foi elaborada utilizando descritores específicos definidos de acordo com a "estratégia de busca PICOS", com os seguintes descritores: P (população) - doença de Alzheimer; I (intervenção) - Uso de Canabidiol; C (comparador) Mecanismo de ação e neuroplasticidade; além disso, operadores booleanos "E". Após a aplicação dos critérios de inclusão/exclusão e elegibilidade, 12 artigos foram incluídos no estudo. Os resultados obtidos mostram que a administração do canabidiol tem um papel positivo em condições neurodegenerativas, especialmente ligadas ao processo de envelhecimento, atuando através das vias de inibição do estresse oxidativo e do processo inflamatório, bem como das vias de Wnt/b-catenina, GSK-3β e PC12.
Actitud y factores asociados a la lactancia materna en madres del Hospital de Alta Especialidad de Veracruz
Authors: García Juan Alberto Méndez , Diez Igbren Guadalupe Rovira , González-López María Kazandra , Alvarado-Martínez Jorge Arturo , Muñíz Elizabeth Aguilar , Farías Jesús de Larrea , Soto-Piedra María Fernanda , Hernández Juan Daniel Euan
Published: January 2024

Introducción: La lactancia materna (LM) es considerada el mejor alimento para el neonato, sin embargo, esta práctica llega a ser poco común. Es posible pensar que la actitud mostrada hacia la LM no favorece a su desarrollo, pues, quizá sea modificada por diversos factores. Objetivo: Identificar la actitud y factores asociados a la lactancia materna en madres en el área de Gineco-Obstetricia del Hospital de Alta Especialidad de Veracruz. Metodología: estudio cuantitativo, descriptivo, prospectivo, transversal, en los meses de abril a mayo 2020. La muestra del estudio fue de 134 pacientes. Para la recolección de datos se utilizó la entrevista personal, el cuestionario Iowa Infant Feeding Attitude Scale (IIFAS). Para el análisis de los factores asociados se elaboró una cédula con datos sociodemográficos. Se usó el programa Statistical Package for the Social Sciences versión 25.0 y Excel 2016, para el análisis estadístico de datos. Resultados: 34.3% de las pacientes encuestadas tienen entre 26 y 30 años, el 2.2% menos de 15. Destaca una actitud neutral hacia la lactancia materna (97%), la regresión lineal mostró que los factores asociados fueron: la escolaridad p= 0.024, tipo de parto p = 0.040 y número de controles prenatales p= 0.005. Conclusiones: La actitud de la lactancia materna está asociada a los factores escolaridad, tipo de parto y número de controles, presentando una actitud neutral hacia la lactancia materna.
PROPAGATION OF TRANSYLVANIAN ENDEMIC AND ENDANGERED PLANT SPECIES
Authors: Lihăt Ildikó , Szekely-Varga Zsolt , Csergő Anna-Mária , Balla Géza , Kentelky Endre
Published: January 2024

Climate change has already caused irreversible stock changes in species distributions in many parts of the world. Species are lost and disrupted because they are highly dependent on changes in temperature. The aim of the experiment is to develop cultivation techniques for wild perennial plants of ornamental value that are rare, protected or highly endangered, thus helping to maintain these plant populations while increasing the number of ornamental plants grown. As plant material we have collected the seeds of Achillea ptarmica, Achillea impatiens, Achillea x girgioensis, Allium obliquum, Silene zawadskii, Dianthus petraeus ssp. orbelicus, and Centaurea triumfettii in two different years. The collected seeds were sown in spring and autumn, alongside these the germination was determined also in Petri dishes. From our results could be determined that at the Caryophyllaceae family both genus seeds germinated reasonably good, in the case of the plants belonging to the Asteraceae family the seeds obtained different results, furthermore at the A. obliquum the germination was low. The present experiment offers the possibilities to multiply these endangered plant species, and to improve the impoverished genetic stock.
EXPERIENTIAL APPRECIATION AS A HEALTH AND LIFE PROTECTIVE RESOURCE
Authors: Vitalia Ileana Loredana
Published: January 2024

Considering the multidimensional structure of the Meaning in Life (MIL) concept, the present paper highlights the importance of experiential appreciation (EA) as one of the key health protective or restorative inner resources sustaining the process of recovery or healing from traumatic/adverse experiences as well the adaptive/proactive coping in various life situations. The ability to connect things (in the form of comprehension, purpose and mattering) is tied to the appreciation of the lived experience to develop a more nuanced yet dynamic understanding of the meaning in life variable. The main purposes of this research were to design and to implement a humanistic-experiential scenario based on the experiential expressive-creative techniques (creative meditation, guided imagery, drawing, and music) to increase the level of experiential appreciation as well as the general meaning in life state. Statistical analyses (Paired Samples T Test) confirmed the efficiency of the experiential scenario. Consistent with other recent studies, our findings suggest that simply appreciating one`s experiences can facilitate the conscious access to the resource of confidence that life is worth living, a resource that emphasizes growth and personal development and not a simple reducing symptoms approach.
Principle of Gate Control Theory: Ayurveda Perspective
Authors: Bhagyashri A. Chakole  , Mahesh K Vyas  , Kamal Kumar
Published: January 2024

There are many procedures explained in Ayurveda to cure pain where mechanical force is not apply like Samhanan, Abhyanga, Udavartana etc. Here we are hypothesizing that those procedure of Ayurveda which indicated in painful condition, work on gate control theory. As according to gate control theory touch factors reduces pain, and many procedures explained below includes touch as part of its methodology. Charak says about pain mechanism where he says that touch is responsible for both Sukha Vedana means alleviate and Dukkha Vedana which means pain. Here Sukha can understand as Anukul Vedana and Dukkha Pratikul Vedana. Also, Acharya Sushruta say that pain is always associated with the Vata dosha. If we look into the gate control theory of pain, network of pain gate there may be the network of emotional domain which needs to find out as Ayurveda procedure works with compassion and gives relief from pain. Materials and Methods: Understanding of Ayurvedic procedure by modern perspective is necessary for its acceptance for this various classical Ayurveda text like Charaka, Sushruta and Vagbhata with their famous commentary are reviewed thoroughly. Along modern physiology literature from various articles and books reviewed. Discussion: Abhyanga, etc., are the therapeutics procedure which aims to give relief from pain. All these procedures include touch sensation. All these procedures are mentioned for therapeutics as well as preventive use. Conclusion: It been concluded that Abhyanga, Samhanan, Udavartana and Agnikarma may work on the pain gate mechanism. All procedures included touch which works as a distractive stimulus to close the pain gate. And one of their benefits is Sukham which can understand as alleviation all kinds of pain.
A Randomised Comparative Clinical Study to Evaluate the Efficacy of Sadhyovirechana with Gandharvahastadi Eranda Taila followed by Agnilepa and Dhanyamla Dhara in the Management of Amavata
Authors: Lavanya.U  , G. S. Hadimani  , Akshay R. Shetty
Published: January 2024

Amavata is a Kruchrasadya vyadhi caused due to formation of Ama, vitiation of Vata and Agni vaishamya. Madhavakara mentions it as a ‘Sa kashtah sarva roganam’. Amavata is an Ama pradhana vyadhi, it requires Ama pachana as primary management. Hence in the present study, Sadhyovirechana as Abhyantara Shodhana Chikitsa followed by Bahya chikitsa in the form of Agnilepa and Dhanyamla Dhara in two different groups were used to evaluate their efficacy in the management of Amavata. Aims and Objectives: 1. To evaluate the efficacy of Sadhyovirechana with Gandharvahastadi Eranda Taila followed by Agnilepa in Amavata. 2. To evaluate the efficacy of Sadhyovirechana with Gandharvahastadi Eranda Taila followed by Dhanyamla dhara in Amavata. 3. To compare the efficacy of both the groups in Amavata. Methods: This is a comparative clinical study with pre-test & post-test design where in 40 patients diagnosed with Amavata of either sex were randomly assigned into two groups viz., Group A & Group B. Intervention: Group A: Sadhyovirechana on 1st day followed by Agnilepa for next 7 days. Group B: Sadhyovirechana on 1st day followed by Dhanyamla Dhara for next 7 days. Results: The effect of the treatment in both the groups were assessed by applying Wilcoxon’s rank sum test within the groups and Mann-Whitney U test between the groups, it showed that Group A showed better results than Group B. Conclusion: It can be concluded from the study that in the management of Amavata, Sadhyovirechana followed by Agnilepa and Dhanyamala Dhara Chikitsa drugs and procedures of both the groups are highly effective in treating Amavata.
Concept of Avapeeda Nasya in Shalakya Tantra
Authors: Rawat Sugandha  , Tiwari Ashish  , Ch.Ramadevi  , K. Anasuya
Published: January 2024

Avapeeda nasya is a special procedure described to treat Urdhwajatrugata vikaras in Ayurveda. In this procedure fresh juice (Swarasa) is obtained by squeezing paste of herbs or decoction is used to instil in nostril. Shalakya is special branch of Ayurveda which deals with the diseases above clavicle (Jatru). Aiming for Vyadhi-parimokshana treatment can be done by Sanshamana or Sanshodhan methods. Panchakarma is Shodhana type in which Nasya is a procedure. Acharyas mentioned Nasa hi shirso dwaram, meaning it is the portal to head (for drug administration). To critically appraise and understand the standard Avapeeda Nasya is the focus of my presentation. Procedure of Avapeeda Nasya, its difference from Sneha nasya, mode of action and other norms are discussed in the paper.

Avapeeda Nasya acts as Shodhana and Shamana. When abundance of Doshas are present Tikshna dravyas are used to clear the channels (Sroto-Shodhana), when Doshas are mild or moderate Shamana dravyas are used. To expel Doshas from upper body, Nasa is the portal to Shiras. The active principle of the medicine used in Nasya reaches Shringataka marma (Sira marma) and is distributed to Moordha- Netra – Shrotra – Kantha and thereby expel morbid Doshas. Drug reaches the target area by crossing nasal mucosa, thereafter transported via nerve tract, systemic circulation or by lymphatics. Intra-nasally administered drug has higher bioavailability as it avoid first pass mechanism at liver and evade BBB.
Ayurvedic Management of Puyalasa (Chronic Dacryocystitis)
Authors: Gagana V N  , Veerayya R Hiremath  , Gururaj N  , Shashikala K  , Raju S N
Published: January 2024

Puyalasa is one of the Sandhigata Vyadhi described by Acharya Sushruta and Vagbhata. It is presented with symptoms of discharge of Puya (pus), Pakwa shopha (swelling), Vrana (wound), Vedana (pain) with Tridosha dushti. Puyaalasa can be co-related with chronic dacryocystitis. It is an infection of the lacrimal sac, secondary to obstruction of the nasolacrimal duct at the junction of lacrimal sac, followed by stasis in the lacrimal sac, causing pain, redness, and swelling over the inner aspect of the lower eyelid and epiphora. In this case study 62-year-old female complaining of pus discharge, watering of eyes associated with swelling over the lacrimal sac in left eye for 3 weeks was treated with application of Jaloukavacharana, along with internally Gandhaka rasayana, Nimbadi guggulu, for 45 days. The results proved to be significant, on the basis of clinical assessment that Ayurvedic management with Jaloukavacharana, and internal medication on the lacrimal sac area offers effective result in the treatment of chronic dacryocystitis.
A Clinical Study on the Effect of Anu Taila Nasya and Shatyadi Vati in Vataja Pratishyaya with special reference to Allergic Rhinitis
Authors: Arti Panwar  , Arun Kumar  , Gunjan Sharma
Published: January 2024

Vataja Pratishyaya (Allergic Rhinitis) is well known for its recurrence and chronicity. Currently approximately 10-30% of adults and 40% of children are affected (feb 2023). A study 2022 revealed that COVID -19 could cause disturbances to the immune system, leading to unusual mast cell activation that may cause allergic flare-ups. Long term usage of nasal decongestants, causes Rhinitis Medicamentosa (RM). Keeping in view the limitations associated with long term usage of modern medications, there is a need to approach Ayurveda treatment for allergic rhinitis. So in present study Anu Taila Nasya and Shatyadi Vati were selected. The trial was conducted on 40 clinically diagnosed patients of Vataja Pratishyaya (allergic rhinitis). Study was carried out in a single group. Anu Taila in the form of Nasya therapy 8 drop of Marsha Nasya of 3 sitting and 2 drop of Pratimarsha Nasya in between 3 sitting of Marsha Nasya in both nostrils, once a day for 35 days along with Shatyadi Vati (500mg) 1 tab BD with lukewarm water for 35 days was given. Result was observed and data was statistically analysed before and after treatment. Highly significant results were found in subjective parameters as well as in objective parameters like sneezing (paroxysmal), nasal obstruction, running nose, itching in the nose, temporal headache, nasal congestion except IgE values (significant result).
Management of Amavata Through Vaitarana Basti w.s.r to Rheumatoid Arthritis
Authors: Murshida Banu  , Waheeda Banu
Published: January 2024

Amavata is one of the crippling disease- causing serious agonizing painful conditions. Some of the symptoms of Amavata can correlated with Rheumatoid arthritis. Rheumatoid arthritis is a common form of inflammatory arthritis, occurring throughout the world and in all ethnic groups. The prevalence of RA is approximately 0.8-1.0% in Europe and South Asia, with a female to male ratio 3:1. Acharya Chakradatta mentioned treatment modalities for Amavata are Langhana, Swedana, Tikta, Deepana, Katu Dravya, purgatives, intake of Sneha and Application of enemas. Teekshna basthi such as Vaitarana basti is indicated in the treatment of Amavata since it possesses qualities like Amapachana, Srotoshodhana and Vatakaphahara. It has Vata kapha pacifying properties and helps in removing Avarana of Vata by Kapha. By using this Chikitsa Siddanta a case of Amavata was successfully treated and marked improvement was observed in signs and symptoms after treatment. Here a case report on Amavata has been discussed along with its effective management with Vaitarana Basti.
ROLE OF RASAYANA CHIKITSA IN THE MANAGEMENT OF FEMALE INFERTILITY W.S.R. HYPOTHYROIDISM- A CASE STUDY
Authors: Gandham Neelima  , V.Narasimha  , A. Vijaya Lakshmi
Published: January 2024

Ayurveda is the Ancient system of Medicine which gives equal importance to preventive and curative aspects of treatment. Rasayana Chikitsa plays a key role in the treatment of all the diseases (both in curative and preventive). There is nothing painful and stressful to women, for not being conceived. In the present modern era, female infertility is raised to the alarming extent due to diet & lifestyle modifications. Couples suffering from the infertility are approaching the infertility centres and going for the artificial reproductive techniques (IUI, IVF, ICSI-ET, Sarogasy). Ayurveda, through its unique line of treatment approaches, paves the way for fertility management through the medicines along with diet & lifestyle modifications. The Commonest cause for fertility being the Hypothyroidism in females (in this present study, I have considered hypothyroidism as Rasa pradosaja vyadi), clinical study was done at OPD, DR. BRKR Govt Ayurvedic College, Hyderabad and treated the patient with Dipana, Pachana, Rasayana Chikitsa and the patient conceived. In this present article an attempt is made to review and understand the concept of Rasayana chikitsa in the management of infertility with special reference to hypothyroidism (Dhatupradosja vyadi).
A Controlled Evaluation of Effect of Madhumeha Nashini Gutika in Sthula Prameha with Reference to Type II Diabetes Mellitus
Authors: Prerna R Masatkar  , Raman R Ghungralekar
Published: January 2024

Ayurveda the science of life is eternal which deals with the healthy as well as diseased individual. Prameha described in Ayurvedic literature is very much similar to the diabetes mellitus of modern medicine with the abrupt change in the modern life style the prevalence of all types of diabetes is on the rise in the world’s population. Charak has mentioned that Sthula Pramehi where Kleda Meda and Kapha are vitiated Apatarpan should be given. Properties of Madhumeha Nashini Gutika prompted us to select the drug in the management of Sthula Prameha. Methodology- The present study is open labelled randomized control trail. The study duration was 12 weeks from the day of recruitment of patients. Group A (trail group) comprised of 20 patients to whom Madhumeha Nashini Gutika 500mg BID was given while in Group B (control group) also comprised of 20 patients treated with tablet metformin in a dose of 500mg BID after food along with drinking water. All the patients were strictly examined according to the criteria of diagnosis having BMI more than 25 were included in the study randomly. Analysis- The outcome measures of this study was to evaluate the effect of therapy on the symptoms of Prameha in terms of % of relief, on physical characters of body such as wt in kg and BMI and biochemical markers such as blood sugar level, HbA1c before and after treatment in both the groups. Results and Conclusion- Overall % of relief in treated group was 73.61% which was more than control group where it was found to be 58.59%. Reduction in weight of patients of treated group was highly significant as t was 8.09 (p<0.001) as compared to control group where t was 0.2525 (p>0.1). Highly significant reduction in BMI values was also noted in treated group as t was 8.83 (p<0.001) as compared to control group where t=0.1625 (p>0.1) so we came at the conclusion that Madhumeha Nashini Gutika might be working on Bahudrava Shleshma and Bahu Abadhdha Meda dhatu.
Peranan Wali Kota Medan dalam Meningkatkan Mutu Pendidikan
Authors: Yunita Lorenda Sri , Tri Mawar Sianturi  , Devi Natalia Hutagalung  , Pretty Marpaung Yolanda
Published: January 2024

This research aims to determine the role of the mayor of Medan in improving the quality of education in the city of Medan. The research methods used are library methods and quantitative methods. The results of the research show that the role of the mayor of Medan has gone well in improving the quality of education in the city of Medan. By providing scholarships carried out by the mayor of Medan