bluuebunny/crossref_metadata_2025 huggingface dataset:
Specification of the basal region identity after asymmetric zygotic division requires mitogen-activated protein kinase 6 in rice
Authors: Ishimoto Kiyoe , Sohonahra Shino , Kaboshi-Kishi Mitsuko , Itoh Jun-ichi , Hibara Ken-ichiro , Sato Yutaka , Watanabe Tsuneaki , Abe Kiyomi , Miyao Akio , Nosaka-Takahashi Misuzu , Suzuki Toshiya , Ta Nhung Kim , Shimizu-Sato Sae , Suzuki Takamasa , Toyoda Atsushi , Takahashi Hirokazu , Nakazono Mikio , Nagato Yasuo , Hirochika Hirohiko , Sato Yutaka
Published: May 2019

Asymmetric cell division is a key step in cellular differentiation in multicellular organisms. In plants, asymmetric zygotic division produces the apical and basal cells. Mitogen-activated protein kinase (MPK) cascade in Arabidopsis act in asymmetric divisions such as zygotic division and stomatal development, but whether the effect on cellular differentiation by this cascade is direct or indirect following asymmetric division is not clear. Here, we report the analysis of a rice mutant, globular embryo 4 (gle4). In two- and four-cell-stage embryos, asymmetric zygotic division and subsequent cell division patterns were indistinguishable between the wild type and gle4 mutants. However, marker gene expression and transcriptome analyses showed that specification of the basal region was compromised in gle4. We found that GLE4 encodes MPK6 and GLE4/ MPK6 is essential in cellular differentiation rather than in asymmetric zygotic division. Our findings provide a new insight into the role of MPK in plant development. We propose that the regulation of asymmetric zygotic division is separate from the regulation of cellular differentiation that leads to apical-basal polarity.
Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk
Authors: Combes Alexander N. , Phipson Belinda , Lawlor Kynan T. , Dorison Aude , Patrick Ralph , Zappia Luke , Harvey Richard P. , Oshlack Alicia , Little Melissa H.
Published: May 2019

Recent advances in the generation of kidney organoids and the culture of primary nephron progenitors from mouse and human have been based on knowledge of the molecular basis of kidney development in mice. Although gene expression during kidney development has been intensely investigated, single cell profiling provides new opportunities to further subsect component cell types and the signalling networks at play. Here, we describe the generation and analysis of 6732 single cell transcriptomes from the fetal mouse kidney [embryonic day (E)18.5] and 7853 sorted nephron progenitor cells (E14.5). These datasets provide improved resolution of cell types and specific markers, including subdivision of the renal stroma and heterogeneity within the nephron progenitor population. Ligand-receptor interaction and pathway analysis reveals novel crosstalk between cellular compartments and associates new pathways with differentiation of nephron and ureteric epithelium cell types. We identify transcriptional congruence between the distal nephron and ureteric epithelium, showing that most markers previously used to identify ureteric epithelium are not specific. Together, this work improves our understanding of metanephric kidney development and provides a template to guide the regeneration of renal tissue.
RACK1 evolved species-specific multifunctionality in translational control through sequence plasticity in a loop domain
Authors: Rollins Madeline G. , Jha Sujata , Bartom Elizabeth T. , Walsh Derek
Published: May 2019

Receptor of Activated C Kinase 1 (RACK1) is a highly conserved eukaryotic protein that regulates several aspects of mRNA translation, yet how it does so remains poorly understood. Here we show that although RACK1 consists largely of conserved β-propeller domains that mediate binding to several other proteins, a short interconnecting loop between two of these blades varies across species to control distinct RACK1 functions during translation. Mutants and chimeras revealed that the amino acid composition of the loop is optimized to regulate interactions with eIF6, a eukaryotic initiation factor that controls 60S biogenesis and 80S ribosome assembly. Separately, phylogenetics revealed that despite broad sequence divergence in the loop there is striking conservation of negatively charged residues amongst protists and dicot plants, which is reintroduced to mammalian RACK1 by poxviruses through phosphorylation. While both charged and uncharged loop mutants affect eIF6 interactions, only a negatively charged plant, but not uncharged yeast or human loop enhances translation of mRNAs with adenosine-rich 5’ untranslated regions (UTRs). Our findings reveal how sequence plasticity in the RACK1 loop confers multifunctionality in translational control across species.
Clavicle fracture following neck dissection: imaging features and natural course
Authors: Fujimoto Keita , Kato Hiroki , Kaneko Yo , Aoki Mitsuhiro , Kuze Bunya , Kato Keizo , Shibata Toshiyuki , Matsuo Masayuki
Published: May 2019

Objective:

This study aimed to assess the imaging features and natural course of clavicle fracture following neck dissection (ND).

Methods and materials:

Eight patients with clavicle fracture following ND were included. Because bilateral clavicle fractures occurred in one patient, a total of nine clavicle fractures following ND were assessed using CT images. Pathological fracture due to bone metastasis or local recurrence was carefully ruled out.

Results:

The time interval from ND to clavicle fracture ranged from 2 to 8 months (median, 4 months). On CT images, all the nine fractures occurred in the proximal clavicles and displayed increased bone marrow density with extraosseous soft-tissue mass formation. Osteolysis of the clavicle was not observed. Intra articular fractures were observed in three (33%), displaced fractures in two (22%), and free bone fragments in three (33%) cases. Further follow-up using CT showed that six (67%) fractures resulted in pseudoarthrosis. For the remaining three (33%) fractures with bone union during follow-up, the time interval between clavicle fracture and bone union ranged from 4 to 16 months (median, 6 months).

Conclusion:

Proximal clavicle fractures, which are rarely observed following ND, always display extraosseous soft-tissue mass formation without osteolysis. They frequently result in pseudoarthrosis; however, occasionally, they also result in bone union within 24 weeks.

Advances in knowledge:

The location of proximal clavicle, the lack of osteolysis, and the presence of free bone fragments may be the key to diagnosis of clavicle fracture following ND.
Ethical and practical issues to consider in the governance of genomic and human research data and data sharing in South Africa: a meeting report
Authors: Staunton Ciara , Adams Rachel , Dove Edward S. , Harriman Natalie , Horn Lyn , Labuschaigne Melodie , Mulder Nicola , Olckers Antonel , Pope Anne , Ramsay Michèle , Swanepoel Carmen , Ni Loideain Nora , De Vries Jantina
Published: May 2019

Genomic research and biobanking has undergone exponential growth in Africa and at the heart of this research is the sharing of biospecimens and associated clinical data amongst researchers in Africa and across the world. While this move towards open science is progressing, there has been a strengthening internationally of data protection regulations that seek to safeguard the rights of data subjects while promoting the movement of data for the benefit of research. In line with this global shift, many jurisdictions in Africa are introducing data protection regulations, but there has been limited consideration of the regulation of data sharing for genomic research and biobanking in Africa. South Africa (SA) is one country that has sought to regulate the international sharing of data and has enacted the Protection of Personal Information Act (POPIA) 2013 that will change the governance and regulation of data in SA, including health research data, once it is in force. To identify and discuss challenges and opportunities in the governance of data sharing for genomic and health research data in SA, a two-day meeting was convened in February 2019 in Cape Town, SA with over 30 participants with expertise in law, ethics, genomics and biobanking science, drawn from academia, industry, and government. This report sets out some of the key challenges identified during the workshop and the opportunities and limitations of the current regulatory framework in SA.
“It builds your confidence… you’ve done well”: Healthcare workers’ experiences of participating in a low-dose, high-frequency training to improve newborn survival on the day of birth in Ghana
Authors: Asiedu Amos , Nelson Allyson R. , Gomez Patricia P. , Tappis Hannah , Effah Fred , Allen Chantelle
Published: May 2019

Background: The majority of newborn deaths occur during the first week of life, and 25‒45% occur within the first 24 hours. A low-dose, high-frequency (LDHF) training approach was introduced in 40 hospitals in Ghana to improve newborn survival. The aim of this qualitative study was to explore healthcare workers’ experiences with the LDHF approach to in-service training.

Methods: A total of 20 in-depth interviews and nine focus group discussions were conducted in 2016 in three regions of Ghana with healthcare workers who participated in implementation of the LDHF training approach. In-depth interviews were conducted with 20 master mentors and peer practice coordinators; 51 practicing doctors, midwives and nurses participated in focus group discussions. Data were analyzed using a thematic analysis approach.

Results: Healthcare workers reflected on the differences between the LDHF approach and past learning experiences, highlighting how the skills-based team training approach, coupled with high-frequency practice and mobile mentoring, built their competency and confidence. As participants shared their experiences, they highlighted relationships established between Master Mentors and healthcare workers, and motivation stemming from pride in contributing to reductions in maternal and newborn deaths as critical factors in improving quality of care at participating health facilities.

Conclusion: This nested qualitative study documents experiences of healthcare workers and mentors involved in implementation of a multi-faceted intervention that effectively improved maternal and newborn care at health facilities in Ghana. The way the intervention was implemented created an environment conducive to learning within the hospital setting, thus providing an opportunity for professional growth and quality improvement for all staff working in the maternity ward.
The neuro-toxin MPTP does not prevent reproduction in marmosets
Authors: Nuara Stephen G. , Burgess Lori A. , Hamadjida Adjia , Gourdon Jim C. , Huot Philippe
Published: May 2019

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neuro-toxin that has been employed to model Parkinson’s disease in non-human primates for over 3 decades. Despite its use for such a long period, little is known about the effects of MPTP on reproductive function. Here, we report the case of a male marmoset which was able to procreate 1.5 year after having been administered the toxin. We also report on 1 male and 1 female MPTP-lesioned marmosets which produced babies after being housed together for 5 years. These cases suggest that MPTP may not interfere with marmoset reproductive function or that if it does, it may be for a limited period of time.
Study design and protocol for investigating social network patterns in rural and urban schools and households in a coastal setting in Kenya using wearable proximity sensors
Authors: Kiti Moses Chapa , Melegaro Alessia , Cattuto Ciro , Nokes David James
Published: May 2019

Background: Social contact patterns shape the transmission of respiratory infections spread via close interactions. There is a paucity of observational data from schools and households, particularly in developing countries. Portable wireless sensors can record unbiased proximity events between individuals facing each other, shedding light on pathways of infection transmission.

Design and methods: The aim is to characterize face-to-face contact patterns that may shape the transmission of respiratory infections in schools and households in Kilifi, Kenya. Two schools, one each from a rural and urban area, will be purposively selected. From each school, 350 students will be randomly selected proportional to class size and gender to participate. Nine index students from each school will be randomly selected and followed-up to their households. All index household residents will be recruited into the study. A further 3-5 neighbouring households will also be recruited to give a maximum of 350 participants per household setting. The sample size per site is limited by the number of sensors available for data collection. Each participant will wear a wireless proximity sensor lying on their chest area for 7 consecutive days. Data on proximal dyadic interactions will be collected automatically by the sensors only for participants who are face-to-face. Key characteristics of interest include the distribution of degree and the frequency and duration of contacts and their variation in rural and urban areas. These will be stratified by age, gender, role, and day of the week.

Expected results: Resultant data will inform on social contact patterns in rural and urban areas of a previously unstudied population. Ensuing data will be used to parameterize mathematical simulation models of transmission of a range of respiratory viruses, including respiratory syncytial virus, and used to explore the impact of intervention measures such as vaccination and social distancing.
Krytyka nowego prawa o ubogich w ujęciu ruchu oksfordzkiego (1833‑1845)
Authors: Musiewicz Piotr
Published: May 2019

The Oxford Movement’s Critique of the Poor Law Amendment ActThe paper presents a short history of poor laws in England and Great Britain, the content and justifications of the Poor Law Amendment Act (1834), general characteristics of the Oxford Movement and its main political ideas, the state of contemporary research on the topic, and finally the Movement’s approach to the new Poor Law. This approach – the Oxford Movement’s critique – has been reconstructed into three main groups of arguments. In the first group there are arguments pointing out why a state’s responsibility, and state-organised system of poor relief, is to be irrelevant and why the Church should play a far greater role in this field. The second group of arguments underlines the impracticality of centralisation in the system and proposes the major role of the local units in poor relief, as well as more ‘personal’ approach to the poor, also by reforming workhouses. The third group of arguments undermines the liberal (and Puritan) idea of solely individual responsibility for one’s poverty and destitution – an idea underlying the new Poor Law.
Instytucjonalne uwarunkowania rywalizacji o władzę w postradzieckich systemach autorytarnych
Authors: Czachor Rafał
Published: May 2019

Institutional Conditions of the Political Rivalry in the Post-Soviet Authoritarian RegimesMore than 25 years have passed since the collapse of the Soviet Union. Despite that, political scientists until now have used the category of ‘post-Soviet countries’, meaning that the Soviet past still determines the direction of the evolution of the political systems of the republics that won their independence in 1991 and that they still share some common features of the political design and have failed to successfully complete the transformation to democracy. The main goal of the following paper is to present institutional conditions that make post-Soviet authoritarian regimes relatively stable and limit the alternation of power. Main conclusions of the paper are the following: firstly, the power in post-Soviet authoritarian countries is held by their presidents who create informal groups of relevant politicians and businessmen that can be treated as neo-patrimonial clients. Secondly, presidential or parliamentary elections are regularly held but are just a facade that is meant to hide and legitimize authoritarian practices of these regimes. Thirdly, in such countries significant role the political life is played by the so-called ‘parties of power’ – non-ideological parties whose only goal is to support the president.
Formy oddziaływaniaorganów władzy wykonawczej na pozarządowe organizacje broniące praw człowieka w Rosji w latach 1991‑1999
Authors: Jach Anna
Published: May 2019

The Forms of Influence of the Executive Organs on the Non-Governmental Organizations Defending Human Rights in Russia Between 1991 and 1999The basic means of influence of the organs of Russian state authority upon the functioning of non-governmental organizations defending human rights is legislative activity. It was with the help of this acitvity that a base was built from the very beginning, thanks to which many non-governmental organizations could be revived or born. From the point of view of the Russian authorities, non-governmental human rights organizations occupy a special place, which has been perceived for 15 years not as support for the ruling elite in the difficult way of shaping a modern state and a democratic society, but as a threat to the functioning status quo. One cannot therefore not get the impression that the regulations concerning the third sector are primarily aimed at hindering or even preventing the activities of non-governmental organizations defending human rights. However, before the vector turned in the policy towards the third sector, in the first period of 1991-1999 we had a positive attitude of the state towards the development of the social sector. The presented article is designed to bring closer the first period of interaction between the state authorities and non-governmental organizations defending human rights, resulting in activities aiming to “regulate” the legal situation of the third sector in the Russian Federation.
Zabójstwo ideologiczne w twórczości Fiodora Dostojewskiego
Authors: Kilar Agata
Published: May 2019

Ideological Killing in the Works of Fyodor DostoyevskyThe key issue of the article is the motivation for murder – the “ethics” of killing. The moral dimension of murder and the killer’s axiological awareness become crucial. The article answers questions about various aspects of murder. Is killing always wrong? Are there any situations in which the categorical ban on taking human life can be relativised in the context of the defence of another human being and higher values? Are there any values for the implementation of which political ideas and ideologies can justify mass murder, and, as a result, bloody revolution, war, and genocide? What is the role of a culture that promotes ideologies based on the idea of killing or internal fighting? The author deals with the issue of ideological murder in Fyodor Dostoyevsky’s novels. The article addresses moral issues concerning the murder, as well as the metaphysical dimension of crime. On the basis of Crime and Punishment and Demons, the author shows what blind faith in ideology can lead to.
Managerial Biases and Debt Contract Design: The Case of Syndicated Loans
Authors: Adam Tim R. , Burg Valentin , Scheinert Tobias , Streitz Daniel
Published: May 2019

We examine whether managerial overconfidence impacts the use of performance-pricing provisions in loan contracts (performance-sensitive debt [PSD]). Managers with biased views may issue PSD because they consider this form of debt to be mispriced. Our evidence shows that overconfident managers are more likely to issue rate-increasing PSD than regular debt. They choose PSD with steeper performance-pricing schedules than those chosen by rational managers. We reject the possibility that overconfident managers have (persistent) positive private information and use PSD for signaling. Finally, firms seem to benefit less from using PSD ex post if they are managed by overconfident rather than rational managers.

This paper was accepted by Gustavo Manso, finance.
Managing Appointment-Based Services in the Presence of Walk-in Customers
Authors: Wang Shan , Liu Nan , Wan Guohua
Published: May 2019

Despite the prevalence and significance of walk-ins in healthcare, we know relatively little about how to plan and manage the daily operations of a healthcare facility that accepts both scheduled and walk-in patients. In this paper, we take a data-analytics approach and develop an optimization model to determine the optimal appointment schedule in the presence of potential walk-ins. Our model is the first known approach that can jointly handle general walk-in processes and heterogeneous, time-dependent no-show behaviors. We demonstrate that, with walk-ins, the optimal schedules are fundamentally different from those without. Our numerical study reveals that walk-ins introduce a new source of uncertainties to the system and cannot be viewed as a simple solution to compensate for patient no-shows. Scheduling, however, is an effective way to counter some of the negative impact from uncertain patient behaviors. Using data from practice, we predict a significant cost reduction (42%–73% on average) if the providers were to switch from current practice (which tends to overlook walk-ins in planning) to our proposed schedules. Although our work is motivated by healthcare, our models and insights can also be applied to general appointment-based services with walk-ins.

This paper was accepted by Gad Allon, operations management.
Revisiting Stochastic Loss Networks: Structures and Approximations
Authors: Jung Kyomin , Lu Yingdong , Shah Devavrat , Sharma Mayank , Squillante Mark S.
Published: May 2019

We consider fundamental properties of stochastic loss networks, seeking to improve on the so-called Erlang fixed-point approximation. We propose a family of mathematical approximations for estimating the stationary loss probabilities and show that they always converge exponentially fast, provide asymptotically exact results, and yield greater accuracy than the Erlang fixed-point approximation. We further derive structural properties of the inverse of the classical Erlang loss function that characterize the region of capacities that ensures a workload is served within a set of loss probabilities. We then exploit these results to efficiently solve a general class of stochastic optimization problems involving loss networks. Computational experiments investigate various issues of both theoretical and practical interest, and demonstrate the benefits of our approach.
An Exact Algorithm for a Rich Vehicle Routing Problem with Private Fleet and Common Carrier
Authors: Dabia Said , Lai David , Vigo Daniele
Published: May 2019

The vehicle routing problem with private fleet and common carrier (VRPPC) is a generalization of the classical vehicle routing problem in which the owner of a private fleet can either visit a customer with one of the owner’s vehicles or assign the customer to a common carrier. The latter case occurs if the demand exceeds the total capacity of the private fleet or if it is more economically convenient to do so. The owner’s objective is to minimize the variable and fixed costs for operating the owner’s fleet plus the total cost charged by the common carrier. This family of problems has many practical applications, particularly in the design of last-mile distribution services and has received some attention in the literature, in which some heuristics were proposed. We extend here the VRPPC by considering more realistic cost structures that account for quantity discounts on outsourcing costs and by considering time windows resulting in a rich VRPPC (RVRPPC). We present an exact approach based on a branch-and-cut-and-price algorithm for the RVRPPC and test the algorithm on instances from the literature.
‘Brace yourselves, the zuera is coming’: memes, letramento midiático digital e apropriação criativa dos fãs de Game of Thrones no Facebook
Authors: Inocêncio Luana , Rebouças Davi
Published: May 2019

Ao investigar como os processos interacionais e de sociabilidade se relacionam com práticas de literacia midiática digital e aprendizagem social nas comunidades online (KNOBEL; LANKSHEAR, 2007), este artigo analisa os diálogos intertextuais nos memes em comentários da página Game of Thrones da Depressão no Facebook, que se utilizam do humor para estruturar coletivamente uma experiência lúdica de consumo, letramento e ressignificação com relação ao produto cultural. A partir de um conjunto de termos e metáforas que são frequentemente referenciados nestes memes da série, um imaginário específico é compartilhado, reconhecido e intensamente apropriado pelos interagentes, constituindo uma rica amostra da intimidade dos fãs com o universo narrativo do programa. Conclui-se que, enquanto micronarrativas que aglutinam saberes de variados campos (ESCALANTE, 2016), os memes de internet envolvem os interagentes em novas práticas criativas de sociabilidade que podem ser compreendidas como literacias – ou letramentos – midiáticas (XAVIER, 2005), posto que nas comunidades digitais são demandadas aos “insiders” certas proficiências (SHIFMAN, 2013; JENKINS, 2008). Destacam-se ao longo desta análise de conteúdo: letramentos com relação às materialidades das TICs nestas plataformas (ferramentas, interfaces); suas usabilidades sociais (“curtir” postagens, responder comentários, marcar usuários, compartilhar posts com nova legenda descritiva adicionada) e conhecimento intertextual (compreensão metalinguística, reconhecer piadas e referências com relação ao universo mencionado, desenvolver novas apropriações destas aplicando variados textos, recursos gráficos e audiovisuais). Neste sentido, percebeu-se a necessidade de reflexões acerca destes múltiplos letramentos nos processos de aprendizagem social em comunidades online, relacionados ao hibridismo de diferentes formas de linguagem nos sites de redes sociais.
MEME E EDUCAÇÃO: ENTREVISTA COM ADRIANA ROCHA BRUNO
Authors: Mello Diene Eire de , Bruno Adriana Rocha
Published: May 2019

MEME E EDUCAÇÃO: ENTREVISTA COM ADRIANA ROCHA BRUNO
Avaliação da cartilha para orientação da prática do autocuidado em Diabetes Mellitus [Evaluation of a primer giving guidance on Diabetes Mellitus self-care] [Evaluación del manual para orientación de la práctica del autocuidado en Diabetes Mellitus]
Authors: Torres Heloisa De Carvalho , Paula Danielle Vasconcellos de
Published: May 2019

Objetivo: investigar a adequação do conteúdo da cartilha quanto ao seu uso para subsidiar as orientações da prática do autocuidado em diabetes. Método: estudo descritivo, exploratório, com abordagem qualitativa. Participaram 15 usuários de duas unidades básicas de saúde situadas em Belo Horizonte. Os dados foram coletados por meio de grupos focais, a partir da discussão para a adequação do conteúdo da cartilha, e tratados pelo método da análise de conteúdo. Resultados: organizados e analisados nas seguintes categorias: clareza e suficiência das informações contidas na cartilha; aparência dos desenhos e adequação do tamanho das letras; ajuda das orientações para o autocuidado. Conclusão: a avaliação da cartilha junto aos usuários foi primordial para que esse material seja utilizado na atenção primária, alcançando os objetivos de educação para o autocuidado.ABSTRACTObjective: to investigate the appropriateness of the booklet’s content to complement diabetes self-care guidelines. Method: the participants in this qualitative, descriptive exploratory study were fifteen users of two primary health care facilities in Belo Horizonte. Data were collected in focus groups, during discussions of the suitability of the booklet’s content, and were treated by the content analysis method. Results: the data were organized and analyzed into the following categories: the clarity and sufficiency of the information in the booklet; the appearance of the drawings and appropriateness of font sizes; and the usefulness of the guidance for self-care. Conclusion: users’ evaluation of the booklet was of prime importance for this material to be used in primary care and attain the objectives of education for self-care.RESUMENObjective: investigar la adecuación del contenido del manual acerca de su uso para subsidiar las orientaciones de la práctica del autocuidado en diabetes. Método: estudio descriptivo, exploratorio, con enfoque cualitativo. Han participado 15 usuarios de dos unidades básicas de salud ubicadas en Belo Horizonte. Los datos han sido recolectados por medio de grupos focales, partiendo de la discusión para la adecuación del contenido del manual, y tratados por el método del análisis de contenido. Resultados: organizados y analizados en las categorías a continuación: claridad y suficiencia de la información contenida en el manual; apariencia de los dibujos y adecuación del tamaño de las letras; ayuda de las orientaciones para el autocuidado. Conclusión: la evaluación del manual junto a los usuarios fue de primordial importancia para que se utilice ese material en la atención primaria, alcanzando los objetivos de educación respecto al autocuidado.
Intravenous versus subcutaneous trastuzumab: an economic and patient perspective
Authors: Mitchell Helen , Morrissey Diane
Published: May 2019

Since 2005, when the first patients outside of a clinical trial were treated with trastuzumab at The Christie NHS Foundation Trust, a nurse-led service has been developed to facilitate and support a safe treatment pathway for patients. There have been significant developments in the number of patients treated, the mode of administration of the drug and patient choice regarding the location of treatment delivery. This article focuses on the change from intravenous to subcutaneous administration, considering patient experience and choice, particularly in light of the advent of biosimilar drugs, which will necessitate a return to the intravenous route. The relative costs of intravenous and subcutaneous administration are illustrated and the results of a patient survey presented, indicating a strong preference for subcutaneous trastuzumab.
A nurse practitioner-led community palliative care service in Australia
Authors: Edwards Julie , Hooper Dawn , Rothwell Gillian , Kneen Kerrie , Watson John , Saurman Emily
Published: May 2019

Background:

Patients want community-based palliative care, but there was no continuity of care for patients at the Sydney Adventist Hospital to receive palliative and end-of-life care within a community setting. A nurse practitioner (NP)-led community palliative care service was developed.

Aims:

To present the background, design, function, and essential elements of the Sydney Adventist Hospital Community Palliative Care Service (SanCPCS).

Methods:

Semi-structured and cyclical discussions with key informants alongside internal document reviews.

Findings:

This is the first description of an NP-led community palliative care service model. The NP role ensured specialist training and extended clinical practice within the community setting. The SanCPCS delivers accessible, continuous, community-based palliative care throughout the patient's palliative and end-of-life journey.

Conclusion:

NP-led models for palliative and end-of-life care in the outpatient or community setting are a logical direction to meet patient need.
Diagnostic Accuracy of a High-Sensitivity Cardiac Troponin Assay with a Single Serum Test in the Emergency Department
Authors: Body Richard , Twerenbold Raphael , Austin Catrin , Boeddinghaus Jasper , Almashali Malak , Nestelberger Thomas , Morris Niall , Badertscher Patrick , McDowell Garry , Wildi Karin , Moss Phil , Rubini Gimenez Maria , Jarman Heather , Bigler Nina , Einemann Rachael , Koechlin Luca , Pourmahram Ghazaleh , Todd John , Mueller Christian , Freemont Anthony
Published: May 2019

OBJECTIVES

We sought to evaluate diagnostic accuracy of a high-sensitivity cardiac troponin I (hs-cTnI) assay for acute coronary syndromes (ACS) in the emergency department (ED). The assay has high precision at low concentrations and can detect cTnI in 96.8% of healthy individuals.

METHODS

In successive prospective multicenter studies (“testing” and “validation”), we included ED patients with suspected ACS. We drew blood for hs-cTnI [Singulex Clarity® cTnI; 99th percentile, 8.67 ng/L; limit of detection (LoD), 0.08 ng/L] on arrival. Patients also underwent hs-cTnT (Roche Elecsys) testing over ≥3 h. The primary outcome was an adjudicated diagnosis of ACS, defined as acute myocardial infarction (AMI; prevalent or incident), death, or revascularization within 30 days.

RESULTS

The testing and validation studies included 665 and 2470 patients, respectively, of which 94 (14.1%) and 565 (22.9%) had ACS. At a 1.5-ng/L cutoff, hs-cTnI had good sensitivity for AMI in both studies (98.7% and 98.1%, respectively) and would have “ruled out” 40.1% and 48.9% patients. However, sensitivity was lower for ACS (95.7% and 90.6%, respectively). At a 0.8-ng/L cutoff, sensitivity for ACS was higher (97.5% and 97.9%, ruling out 28.6% patients in each cohort). The hs-cTnT assay had similar performance at the LoD (24.6% ruled out; 97.2% sensitivity for ACS).

CONCLUSIONS

The hs-cTnI assay could immediately rule out AMI in 40% of patients and ACS in >25%, with similar accuracy to hs-cTnT at the LoD. Because of its high precision at low concentrations, this hs-cTnI assay has favorable characteristics for this clinical application.
The Internet in a diasporic and transnational context: A case study of a Greek community in Italy
Authors: Pelliccia Andrea
Published: May 2019

Through field research on Greek second-generation migrants in Italy – a hitherto unexplored and under-represented population – this article examines their use of the Internet in a diasporic and transnational context. More specifically, it explores the ways in which the Greek second generation uses the Internet in order to maintain ties with Greece and seeks to understand the role that the Internet performs in the context of diaspora. Moreover, the diasporic media content on the Internet and the interconnection between online and offline worlds will be analysed in order to assess the impact of the Internet on diasporic networks and interpersonal relationships, especially with reference to critical events such as the Greek debt crisis. The research findings show that the maintenance of ties with the motherland is deeply affected by a mass-mediated imaginary that frequently transcends national space. The ease and frequency with which the Internet crosses borders produce undeniably new ways of imagining the place of origin and create alternatives to the nation state, in terms of emotional belonging and identifying transnationally with other diaspora members.
History as trauma and the possibility of the future: Theo Angelopoulos’ Voyage to Cythera
Authors: Homer Sean
Published: May 2019

Theo Angelopoulos has described Taxidi sta Kythira (Voyage to Cythera) (1984) as an attempt to ‘exorcise the past’ and offer the Greek audience a possibility to face the future without the traumas of the past. This article explores the question of the extent to which we can exorcise the past and asks if a future is possible without acknowledging the traumas of the past. Drawing upon cultural trauma theory, the article analyses the Greek Civil War (1946–49) as a cultural trauma for the Greek Left, especially concerning the recognition of political prisoners and exiles. Psychoanalytic theory, on the other hand, suggests that a fundamental characteristic of trauma is the un-representability of the event itself, as a traumatic event is only known through its persistent reiterations. Through its multi-layered narrative structure and aesthetic strategies of deferral and displacement Voyage to Cythera stages the trauma of the Greek Civil War for both the returning exiles and the generation that followed. As a representation of presence through absence, the article considers Voyage to Cythera in terms of Thomas Elsaesser’s concept of the parapractic text and Max Silverman’s notion of palimpsestic memory whereby the film does not exorcise the past as such but reveals a past haunting the present. The article concludes with the reflection that a traumatic past has a tendency to return however much we may wish to lay it rest.
Performing euphoric cosmopolitanism: The aesthetics of life and public space in psytrance phantasmagoria
Authors: Kyriakopoulos Leandros
Published: May 2019

How can we conceive the cosmopolitan ideal of travelling and experiencing exotic difference, so much embraced by ‘countercultural’ practices, once it is aestheticized into phantasmagorical dream-worlds? How can we think of people getting wasted due to drug-fuelled, long-lasting dancing without resorting to idealisms of ‘alternate experiences’ and romanticisms about ideal ways of belonging? This article explores psytrance festivals – a cultural product of the Electronic Dance Music (EDM) carnivalesque celebrations, drug consumption (for the most part LSD and MDMA) and euphoric travelling of the 1960s – with an emphasis on cosmopolitanism, aesthetic intimacy and the care of the self. By examining the mobility of Greek aficionados in EDM festivals in Europe, which have gained great popularity since the first decade of the twenty-first century, I discuss the enactment of the chemical celebration in accordance with the sensorial formations, desiring-images and narratives that weave the imagination of psytrance music culture. In contrast with most of the academic literature that views EDM events as a ‘heterotopic’ set-up that facilitates ‘liminal experiences’ – supposedly evidence of the possibility of an out-of-the-ordinary lifestyle as opposed to everyday normativity – I propose to investigate the excesses of consumption and bodily expenditure within metaphors that support psytrance technoaesthetics.
La más sensorial de las profesiones. El papel de los sentidos en la comunicación médica
Authors: González María , Cantabrana Begoña , Hidalgo Agustín
Published: May 2019

La observación del enfermo es un elemento crítico de la anamnesis y el diagnóstico médico. Si bien el desarrollo científico y técnico puede aportar información de gran valor, el uso de los sentidos, fundamentalmente de la vista, el oído y el tacto, es importante en el acto médico tanto por la información que aportan como por la interacción humana con el enfermo. El sentido de la vista informa de alteraciones morfológicas y funcionales; el del oído permite discernir entre normalidad y patología en el funcionamiento visceral; el del tacto informa sobre cualidades de determinadas afecciones, además de aportar el componente mitológico/religioso de la sanación por imposición de manos. Pero, por otra parte, el enfermo puede utilizar los sentidos para obtener información y extraer conclusiones sobre el comportamiento del médico a través de los gestos, la expresión verbal, la presencia y actitud, e incluso el olor percibido en la interacción entre médico y el enfermo.
Rio Místico / Mystic River (2003 ): Hay hilos en nuestras vidas. Si uno tira de ellos, todo lo demás se ve afectado
Authors: Bocic Maritza , Vargas Angélica
Published: May 2019

En nuestro taller de cine, actividad docente semanal para internos de la carrera de medicina, hemos elegido esta película Rio Místico, a través de ella hacemos un análisis del impacto en el desarrollo de la personalidad y los vínculos. Clint Eastwood nos relata la historio de tres amigos, que presencia el rapto y abuso sexual de uno de ellos, 25 años después los personajes se encuentran por otro hecho trágico, revelándose el que ocurrió hace 25 años. El tiempo y el silencio marco y determino la vida de sus protagonistas
Irodalomértés és kreatív szövegfeldolgozás a digitális magyarórán
Authors: Gonda Zsuzsa , Molnár Gábor Tamás
Published: May 2019

A tanulmány a digitális eszközöknek és médiumoknak az irodalomtanításra gyakorolt hatását vizsgálja. A vonatkozó nemzetközi szakirodalom áttekintésében az irodalomolvasás és a digitális kultúra közötti feszültséget és ugyanakkor lehetséges kapcsolódásokat vizsgálja. Bemutatja az irodalomolvasás eltérő kortárs tipológiáit, így Hayles háromosztatú modelljét, a szövegbe belefeledkező és a kritikai olvasás kölcsönviszonyát, valamint a szoros olvasás fogalmának újabb átértelmezéseit a digitális közegben. Ezek az újraértelmezések a nem-szöveges médiaeffektusok szövegként olvasását szorgalmazzák, másfelől nagyobb hangsúlyt fektetnek az olvasás társas és kontextuális jellegére is – miközben a szövegek nyelvi részleteire való odafigyelésről sem feledkeznek meg. A tanulmány második része egy iskolai kísérletet mutat be, amely empirikus adatokkal járul hozzá a kortárs vitákhoz. A kísérletben a diákok kreatív digitális eszközök (gondolattérkép-készítő, kollaboratív szövegszerkesztő, kép- és videoszerkesztő szoftverek) segítségével dolgoztak fel irodalmi műveket. A kísérlet eddigi eredményei azt sejtetik, hogy a kreatív és interaktív digitális módszerek nem eltávolítják a diákokat az irodalmi szövegtől, hanem éppen elmélyíthetik és segíthetik az irodalom megértését.
A kreativitás fejlesztése digitális eszközökkel támogatott tanulási környezetben: Mit üzennek a kutatások az osztályterem számára és mikor hallgatnak?
Authors: Bereczki Enikő Orsolya
Published: May 2019

Számos elméleti munka mutatott rá arra, hogy digitális technológiák tulajdonságaik révén a kreativitás támogatásának fontos eszközévé válhatnak. A pedagógusok maguk is úgy vélik, hogy digitális eszközök segítségével jól fejleszthető a tanulói kreativitás. Ugyanakkor kutatások bizonyítják, hogy a digitális eszközök használata önmagában nem fokozza a tanulás eredményességét. Az ezen eszközökkel támogatott kreativitásfejlesztés is csak abban az esetben lehet hatásos, ha a tanulási folyamat tervezői és résztvevői értik, mi a kreativitás, hogyan fejleszthető, és képesek kiválasztani a fejlesztésben alkalmazható megfelelő digitális eszközöket. Tanulmányunk ebben kíván segítséget nyújtani a kreativitás, tanulás és digitális technológia összefüggéseit vizsgáló legfontosabb kutatások eredményeinek áttekintésével.
Etanol e ácido cítrico aumentam a longevidade de gérberas cv. Mistique
Authors: Maia Rúbia Kécia Marins , Silva Edivan Amaro da , Alves Rafael Mateus , Morais Maria Aparecida Dos Santos , Vieira Marcos Ribeiro da Silva , Da Silva Luzia Ferreira , Simões Raquel Ferraz Jardim , Fonseca Kelem Silva , Simões Adriano Do Nascimento
Published: May 2019

Ethanol and citric acid can increase longevity in some cut flowers. However, its use must be extremely careful, with application methods and specific concentrations for each type of cut flower. Thus, the objective was to examine the physico-chemical and physiological changes in Gerbera cv. Mistique cut flowers treated with ethanol (Et) and/or citric acid (CA). Stem were selected and standardized to a length of 35 cm and maintained at 20 ± 2 ºC and RH 65 ± 2%, under continuous lighting. The flowers were subjected to two application methods (pulsing for 48 h and maintenance), using different concentrations of Et (4%, 6%, and 8%) and/or CA (100 and 200 mg L-1) and distilled water (control). A visual assessment and analyses of longevity, stem bending, fresh mass, relative water content, electrolyte leakage, and peroxidase and polyphenol oxidase enzyme activities were performed at every two days. The Et (4%) + CA (100 mg L-1) solution provided the greatest longevity, regardless of the application method. These results were the basis for a third experiment, in which the stems were immersed in pulsing solutions of Et (4%) and/or CA (100 mg L-1) and distilled water (control). The Gerbera flowers under Et + CA solution showed lower fresh mass loss and electrolyte leakage, higher relative water content and a slower increase in polyphenol oxidase and peroxidase activities. This allowed for delayed stem bending and better appearance, resulting in greater longevity compared to the other solutions.
Expression of Prostate-Specific Membrane Antigen in Tumor-Associated Vasculature Predicts Poor Prognosis in Hepatocellular Carcinoma
Authors: Jiao Dian , Li Yu , Yang Fa , Han Donghui , Wu Jieheng , Shi Shengjia , Tian Feng , Guo Zhangyan , Xi Wenjin , Li Guodong , Zhao Aizhi , Yang An-Gang , Qin Weijun , Wang He , Wen Weihong
Published: May 2019

INTRODUCTION:

Prostate-specific membrane antigen (PSMA) was originally found to be specifically expressed in normal prostate, and its expression was upregulated in almost all stages of prostate cancer. In recent years, PSMA was also found to be expressed in tumor-associated vasculature in many nonprostatic solid tumors. However, the expression pattern of PSMA in hepatocellular carcinoma (HCC) is not well studied.

METHODS:

In this study, we examined PSMA expression in 103 HCC tissues using immunohistochemical staining and analyzed the association between PSMA expression and other clinicopathological features and prognosis.

RESULTS:

Among the 103 cases, 27 cases (26%) showed PSMA expression in more than 50% of tumor-associated vasculature, 49 cases (48%) showed PSMA expression in less than 50% of vasculature, and 27 cases (26%) did not have detectable PSMA expression. Vascular PSMA expression was associated with several clinicopathological features, such as tumor stage, tumor differentiation, lymph node metastasis, and Ki-67 index. Furthermore, high vascular PSMA expression was also associated with poor prognosis in patients with HCC. Univariate and multivariate analyses showed that high vascular PSMA expression can be used as an independent prognostic marker for HCC.

DISCUSSION:

Our study provides the evidence that PSMA is specifically expressed in tumor-associated vasculature of HCC, and vascular PSMA expression may be used as a novel prognostic marker and a vascular therapeutic target for HCC.
Sentidos de sexualidade nos anais dos Encontros Nacionais de Ensino de Biologia (2005-2016)
Authors: Pinho Raquel , Bastos Felipe
Published: May 2019

Este artigo objetiva compreender os sentidos de sexualidade atribuídos às produções científicas apresentadas no Encontro Nacional de Ensino de Biologia (ENEBIO). Todos os 2.517 trabalhos apresentados nas seis edições do encontro foram triados através de ferramentas de busca e 107 foram selecionados de acordo como recorte desejado: temas relativos a sexualidade, tais como sexo, gênero, DST, gravidez, entre outros. Concluímos que a sexualidade é uma área emergente e em consolidação nos encontros, visto o aumento de trabalhos relacionados ao longo dos anos. Os artigos foram majoritariamente escritos por autoras mulheres, de universidades públicas. De modo geral, as pesquisas têm como foco estudantes e professoras da educação básica, principalmente do ensino fundamental. Quantitativamente, observamos o predomínio da abordagem sociológica da sexualidade, mas também foram analisadas abordagens biológicas, psicológicas e éticas. Por fim, traçamos algumas considerações sobre a importância de se analisar o campo, tanto para a pesquisa quanto para a docência.

PALAVRAS-CHAVE: Sexualidade. Gênero. Evento científico. ENEBIO.
«Hasta los confines de la tierra» (Hch 1,8): vocación universalista en la doble obra lucana
Authors: Busto Saiz José Ramón
Published: May 2019

El judaísmo basculó siempre entre el universalismo y el particularismo identitario. La fe cristiana superó desde el principio el particularismo judío. Todos los seres humanos están llamados a la fe y la Iglesia es católica, es decir, universal. Todos los escritos del N. T. son testigos de ello. La doble obra lucana no es una excepción. En el artículo, tras caracterizar literaria e históricamente los dos libros de Lucas, se pone de relieve el universalismo que se refleja en los aspectos étnicos, culturales y sociales, así como la atención de Lucas a la historia universal.
Un solo manuscrito en dos bibliotecas: el comentario de Raši a la Biblia
Authors: Ortega-Monasterio M. Teresa
Published: May 2019

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The « Caesarean » Text of the Gospel of Mark : Lake Revisited
Authors: Lafleur Didier
Published: May 2019

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Le cheval dans l’onomastique du Sud-Ouest de l’Anatolie
Authors: Locatelli Lauriane
Published: May 2019

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La « Barbarisation » d’Éphèse vue à travers le prisme de l’anthroponymie
Authors: Bouzid-Adler Fabrice
Published: May 2019

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Création et alliance. Une mise en regard de Gn 1,14-2,1 et Dt 4,(13)15-19,32
Authors: Van de Sande Axel
Published: May 2019

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Une petite tablette néo-sumérienne d’Umma de la collection Van de Sande
Authors: Lecompte Camille , Van de Sande Axel
Published: May 2019

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