bluuebunny/crossref_metadata_2025 huggingface dataset:
The connection between nicotinic and adenosinic system in analgesia
Authors:   Department of Occupational Medicine, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 8, Eroilor Sanitari Street, 050474, Bucharest, Romania, HANDRA CLAUDIA MARIANA , GHITA ISABEL ,   Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 8, Eroilor Sanitari Street, 050474, Bucharest, Romania, GEORGESCU DANIELA ,   Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, 8, Eroilor Sanitari Street, 050474, Bucharest, Romania, CHIRILA MARINELA ,   „Titu Maiorescu University”, Faculty of Pharmacy, Bucharest, Romania
Published: May 2024

Determination of analgesic effects of different substances is important since this a very complex process that occur in the human body. The purpose of the present study was to evaluate the analgesic effect of caffeine and nicotine, both alone and in combination, using writhing test and hot plate test. The study used Swiss albino strain male mice, weighting 25 to 35 grams. The substances were administered subcutaneously. In the first experiments caffeine was administered in doses of 1 mg/kg and 5mg/kg and nicotine in doses of 1 mg/kg and 4 mg/kg. The last experiment evaluated the association between caffeine 5 mg/kg and nicotine 4 mg/kg. 30 minutes after administration, both doses of caffeine caused an antinociceptive effect, while nicotine induced analgesia only when the dose was increased to 4 mg/kg bw. Furthermore, when administered simultaneously, the two substances behaved like potentiating each other’s effect, but additional research is needed in order to understand the mechanism of action.
Practicas editoriales en las revistas culturales y literarias hispanoamericanas (1894-1910)
Authors: Pérez Robles Shirley Tatiana
Published: May 2024

Este artículo que se inscribe dentro de la línea de historia intelectual, estudia nueve revistas culturales hispanoamericanas de Argentina, Chile, Colombia y México, publicadas entre 1892 y 1911. El objetivo es mostrar los puntos de similitud y diferencia, para ello se creó una metodología de análisis en las que se observaron las practicas editoriales revisteriles, es decir, la creación, composición, financiación y circulación. En conclusión, este análisis permitió observar que los intelectuales de este periodo, aunque separados en el plano geográfico, contribuyeron a la estructuración de la revista como medio de comunicación especializado en cultura a nivel local y mundial.
Production and optimization study of biodiesel produced from non-edible seed oil
Authors: Jamil Muhammad Ammad
Published: May 2024

The fuel demand is increasing globally. Conventional fuel is toxic and causes global warming and pollution. Therefore, biodiesel is being used as an alternative to petroleum fuel because it is non-toxic and can be renewable. Nowadays, the non-edible feedstock is gaining more attention for the production of biodiesel because it can grow anywhere on land, has low cost, and does not cause an imbalance in the food economy. This study deals with the biodiesel production and optimization of biodiesel from Ricinus communis oil using sodium hydroxide (NaOH) and potassium hydroxide (KOH) as solid base catalysts. The free fatty acid content (22.14% mg KOH/g) of castor oil calculated before transesterification indicated that the pretreatment of raw oil with acid was required for biodiesel synthesis. Therefore, the esterification process was used to reduce the free fatty acid content of castor oil from 22.14% to 0.84%. After that, the transesterification process was used for the production of biodiesel using a catalyst (NaOH and KOH). The four different parameter reactions (i.e. Ratio (alcohol to oil), Time, Temperature, and catalyst amount) were used to optimize the yield of biodiesel production. Firstly, NaOH was used as the catalyst and different reactions were done by making changes in all parameters to get maximum yield. The same procedure was done to get maximum yield using KOH as the catalyst. The maximum yield obtained using NaOH and KOH was 94.6% and 96.2% respectively. In the future, initiatives to develop market, policy support, and certification plans for sustainability play a vital role in innovative advancement, gaining market trust, and attracting investment for biodiesel. These efforts enable biodiesel as a renewable energy source in advancing in low-carbon and sustainable future.
& o vso de diuersas partes do Brasil sera o milhor mestre: o conceito de uso no pensamento linguístico de Anchieta
Authors: Kaltner Leonardo Ferreira , Cardozo Silva dos Santos Melyssa
Published: May 2024

Estudar as línguas indígenas é, de certa forma, apoiar as cauas sociais e políticas atuais dos povos originários. O artigo tem como objetivo debater o conceito de uso segundo o pensamento linguístico de José de Anchieta (1534-1597), a partir do texto Arte de gramática da língua mais usado na costa do Brasil (Anchieta, 1990 [1595]). O termo uso é registrado em diversos momentos em sua gramática que descreve a língua tupinambá empregada nas atividades de catequese intercultural da América portuguesa quinhentista. A fundamentação teórico-metodológica a ser empregada na pesquisa é a Historiografia da Linguística, conforme o modelo de Konrad Koerner (2014) e Pierre Swiggers (2019; Batista, 2019), em que temos como escopo a investigação do pensamento linguístico (linguistic thought) de Anchieta. Como resultado da investigação, encontramos a relação do emprego do termo uso na obra do missionário com concepções teológico-filosóficas e gramaticais que influíram em seu pensamento, o que denota o pensamento linguístico vigente na política missionária da América portuguesa do século XVI, em que a sua obra gramatical se situa.
İş Özellikleri ve Örgüt Kültürünün İş Erteleme Davranışı Üzerindeki Etkisinde Dış Kontrol Odaklılığın Düzenleyici Rolü
Authors: Karkı Ahmet , Bayramoğlu Gokben
Published: May 2024

Bu çalışmada amaç, iş özellikleri ve örgüt kültürü değişkenlerinin iş erteleme üzerindeki etkisini incelemek ve bu etkide dış kontrol odaklılığın düzenleyicilik rolünün olup olmadığının belirlenmesidir. İş erteleme hem günlük yaşamda hem de profesyonel ve akademik alanlarda yaygın bir sorun olarak kabul edilmekte ve örgütsel verimliliği olumsuz yönde etkilemektedir. Literatürde, erteleme davranışının çoğunlukla bireysel faktörlerle, özellikle öz-düzenleme ve zaman yönetimi becerilerindeki eksikliklerle ilişkilendirildiği; ancak durumsal görevle ilgili ve kişisel özelliklerin etkileşiminin yeterince ele alınmadığı görülmektedir. Bu bağlamda mevcut çalışma, erteleme davranışını daha kapsamlı bir şekilde anlamayı ve öngörmeyi amaçlayarak bu faktörlerin etkileşimini değerlendirmektedir. Araştırmanın örneklemini, Türkiye’nin yedi farklı bölgesinde bulunan büyük şehirlerde yaşayan 714 kamu görevlisi oluşturmaktadır. Yapılan analizler, iş özellikleri ile klan ve adhokrasi kültürü algılarının iş erteleme davranışı üzerinde istatistiksel olarak anlamlı ve negatif etkilere sahip olduğunu ortaya koymaktadır. Buna karşın hiyerarşi ve piyasa kültürü algılarının iş erteleme davranışı üzerinde pozitif ve anlamlı etkileri olduğu belirlenmiştir. Ayrıca, iş özellikleri ve örgüt kültürünün iş erteleme davranışı üzerindeki etkilerinde dış kontrol odaklılığın düzenleyici bir role sahip olduğu tespit edilmiştir.
Teletransporter and other troubles
Authors:   Tyumen State University, Kochnev R. L.
Published: May 2024

The article is a commentary on the work of Alexey Kardash Teletransporter and Origami. It critically analyses the objections to the survival of the person in teleportation: about hidden dualism, about violation of cause-and-effect relations and about reflexive predicament. To answer, a reconstruction of Javier Hidalgo’s views presented in Survival of Teleportation is used. It is concluded that the objections raised by Alexey Kardash are problematic.
The introduction of the metric system of weights and measures in the Omsk district in the 1920s
Authors:   National Research Tomsk State University, Makarov I. V.
Published: May 2024

The article is devoted the process metric reform of the 1920s, which is one of the most important parts of the history of Russian and Siberian metrology and an integral part of the socio-economic modernization of the USSR, in the Omsk district. The purpose of the article is to establish the circumstances of the metric reform in the Omsk district, as well as to identify the problems and difficulties that arose during the transition to the metric system of weights and measures. The main sources for writing the article are the files of the funds the Historical Archive of Omsk Region, primarily the fund of the Omsk Chamber of Weights and Measures; the files from State Archive of Novosibirsk Region are also used. The article describes the process of transition to the metric system in the Omsk district through the activities of the district interdepartmental metric commission and the verification chamber of weights and measures. Based on the results of the study, conclusions are drawn about the progress of the metric reform in the Omsk district.
The Vice-governor in the system of the administrative elite of steppe regions in the West Siberian and Steppe General-Governorships in the second half of the XIX–beginning of XX century
Authors:   Dostoevsky Omsk  State University, Mikhailenko E. I.
Published: May 2024

The article analyzes the position of Vice-governor in the system of administrative elite of Akmola, Semipalatinsk and Semirechensk regions of the Russian Empire. Using the normative-legal base of local institutions of these regions, the «formal» position of officials in this position in the general structure of administrative power is characterized. Management in steppe regions is characterized by remoteness of territories from the center of decision-making, high share of nomadic population, marginal position. In this regard, the peculiarities of the position of Vice-governors in the steppe regions and in the interior of Russia are revealed. One of the important features of the service of these officials is the combination of military and civil power in the steppe regions and the lack of a clear division of responsibilities between the elements of the administrative elite. For the socio-cultural characterization of the composition of the Vice-governor corps we used the form lists and personal files of officials kept in the archives: the Historical Archive of the Omsk Region, the Russian State Historical Archive and the Central State Archive of the Republic of Kazakhstan. These data are published for the first time. The article concludes with a socio-cultural portrait of a typical Vice-governor of a steppe region, an analysis of the typical career trajectories of the official and a comparison of the scope of authority with similar officials from internal Russian provinces.
Tiempo, Experiencia y Muerte
Authors: Tomasini Bassols Alejandro Tomasini Bassols
Published: May 2024

Mi punto de partida en este escrito es el deseo de responder a la pregunta de por qué estar muerto durante un día es exactamente lo mismo que estar muerto durante un millón de años. En la primera parte del trabajo me aboco a tratar de explicar en qué consiste concretamente la utilidad del concepto de tiempo. Acto seguido, conecto mis observaciones con un pronunciamiento particularmente relevante e importante del Tractatus, referente a que la muerte no es una vivencia. De manera general, mi punto de vista es que el “tiempo” es ante todo un concepto organizativo, clasificatorio, etc. (como “espacio”), es decir, sirve para poner orden en nuestras experiencias, puesto que permite coordinar el orden o la secuencia de los acontecimientos con mi subjetividad, es decir, con mi perspectiva particular de la realidad. El concepto de tiempo integra lo que a menudo es descrito como “tiempo mental” y como “tiempo físico” o, como en el caso de Wittgenstein, como el “tiempo de la información” y el “tiempo del recuerdo”. Con base en esta dicotomía examino críticamente la concepción sustancialista del tiempo, la cual hace del ‘tiempo’ un nombre, y que desde mi perspectiva queda refutada. Por último, ejemplifico la utilidad del uso del término ‘tiempo’ en el lenguaje coloquial y culmino ofreciendo mi explicación de por qué efectivamente el tiempo no se aplica a los muertos.
A genealogia e o governo da vontade: hipóteses de pesquisa
Authors: Rodrigues Malcom Guimarães
Published: May 2024

No presente artigo, procuramos apresentar os termos de uma genealogia da vontade que se depara com a problematização do dispositivo de sexualidade e com as formas pelas quais, por meio desse dispositivo, é possível governar os indivíduos. Nosso objetivo é apresentar as bases norteadoras de uma pesquisa intitulada “Foucault e o governo da vontade”. Trata-se de delinear o campo de trabalho e defender a pertinência de seus resultados, à luz da genealogia da subjetividade de Foucault. A partir desta genealogia, a problematização dos modos pelos quais se tornaram possíveis as patologizações da sexualidade, na contemporaneidade, pressupõem a devida compreensão da articulação entre a experiência cristã da carne e o dispositivo moderno de sexualidade.
O retributivismo da punição na Doutrina do Direito
Authors: Meirelles Luís Miguel Rechiki
Published: May 2024

The present study aims to analyze the Kantian response to the problem of punishment. Such a problem consists of how we can justify the application of a reprobative retributive damage to a transgressive agent by the State. To this end, I will focus on the work Metaphysics of customs and some commentator texts on the work and the subject. The analysis aims to highlight the contribution made by Kant to the problem of the justification of punishment, in addition to assessing the positive and negative points of considering the philosopher's response. At first, the problem of punishment will be exposed, followed by the justification proposal presented by Kant. In the third part of the study, we will highlight some positive points found in the Kantian proposal followed, evidently, by the highlight of the negative points of this proposal. In conclusion, the philosopher seems to present important concepts that, I understand, must be considered by contemporary responses to the problem of punishment.
A crise ecológica e a salvaguarda das condições de vida: exigências éticas e premissas para um novo humanismo
Authors: Kambalu Lourenço Flaviano
Published: May 2024

The interdependence and fundamental equality of all people in terms of dignity and rights leads us to postulate more humane and just living conditions, as well as to reflect on what haunts it, such as the prevailing liberalist and utilitarian tendencies and ecological imbalances. There has been greater sensitivity towards the environment and ethical proposals have been adopted to deal with this emergency, but the trend has not yet been reversed or changed. Nature continues to be treated as a res nullius and the effects of this trend are increasingly jeopardising the environment. It is therefore urgent to reflect on the crisis threatening the planet and re-establish the conditions for the survival of our "common home". Such a proposed solution may be possible with an ethical stance, i.e. by realising that every living being needs the vital conditions of a healthy environment. Ethical reflection as a proposed solution to the ecological crisis is justified by the fact that the context of interdependence between organisms and the habitat in which they find themselves, imposes rules that create a sense of belonging from which obligations and duties derive, and creates the awareness that what contributes to the preservation, integrity, stability, beauty and balance of the planet is just and good
Non-diffractive intraocular lens with extended depth of focus optical power calculation
Authors:   Excimer Eye Centre, Moscow, Russian Federation, Pershin K.B. ,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russian Federation, Pashinova N.F. ,   Excimer Eye Centre, Moscow, Russian Federation,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russian Federation, Tsygankov A.Y. ,   Excimer Eye Centre, Moscow, Russian Federation, Antonov E.A. ,   Excimer Eye Centre, Moscow, Russian Federation
Published: May 2024

Purpose. Retrospective analysis of the accuracy of 7 formulas for calculating the optical power of a non-diffractive intraocular lens (IOL) with extended depth of focus. Material and methods. The retrospective study included 48 patients (81 eyes) with AcrySof IQ Vivity EDOF IOL implantation. The IOL optical power range was +15.0 to +30.0 D, and the target refraction was –0.25 to 0.25 D. The mean age of the patients was 59.1±7.7 (40–84) years.The SRK/T, Barrett Universal II, Haigis, Hoffer Q, Holladay 2, Olsen, and Kane formulas were retrospectively analyzed for effectiveness using appropriate constants. Each formula was optimized for the study group of patients to achieve an average refractive error as close to zero as possible. For each formula, the mean error (ME), mean absolute error (MAE), standard deviation (SD), median absolute error (MedAE), maximum absolute error (MaxAE), and percentage of eyes within the error range of 0.25, 0.5, 1.0, and 2.0 D were calculated. Results. The optimized constants were LF = 2.18, a0 = 1.39, a1 = 0.41, a2 = 0.13, personalized ACD = 5.74, ACD (Hoffer Q/Holladay 2) = 5.64/5.50, A-constant (SRK/T/Kane) = 119.2/119.3. The lowest MAE is determined for Kane, Barrett Universal II, and SRK/T formulas (p<0.05). The use of Haigis and Olsen formulas was characterized by a lower MAE compared to Holladay 2 and Hoffer Q formulas (p<0.05). With the exception of the Haigis and Hoffer Q formulas, all other formulas are shown to fall within the target refraction of ±2.00 D. With the Kane, Barrett Universal II and SRK/T formulas, 100% target refraction of ±1.00 D, 98‒99% target refraction of ±0.50 D, and greater than 80% target refraction of ±0.20 D were determined. Conclusion. In this study, we retrospectively evaluated the performance of seven formulas for calculating the optical power of the Acrysof IQ Vivity EDOF non-diffractive intraocular lens. The best results were shown for the Kane, Barrett Universal II and SRK/T formulas. Key words:cataract, phacoemulsification, EDOF, Symfony, IOL optical power calculation, constant optimization
Gene therapy for hereditary retinal diseases
Authors:   Bashkir state medical University, Ufa, Russian Federation, Ziyazetdinova R.Y. , Tukhvatshina I.A. ,   All-Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Orenburkina O.I. ,   All-Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Bikkuzin T.I. ,   Bashkir state medical University, Ufa, Russian Federation, Ismagilova L.N. ,   Bashkir state medical University, Ufa, Russian Federation
Published: May 2024

This scientific literature review demonstrates high prospects of recent developments in gene therapy for the treatment of retinal diseases. First of all it concerns inherited pathologies such as retinitis pigmentosa and Leber congenital amaurosis. Nevertheless gene therapy is still quite far from its tangible application in clinical practice for other retinal diseases, although preliminary trial outcomes of its use for some of them (for example, achromatopsia, congenital X-linked retinoschisis) turn to be very promising. The data presented in this review inspire hope that gene therapy will be more accessible and widely-used in clinical practice. Key words:retinal diseases, inherited retinal diseases, gene therapy, voretigene neparvovec
Some risk factors for anterior segment inflammation after cataract surgery in patients with glaucoma (case series)
Authors:   Clinical Hospital «RZD-Medicine», Penza, Russian Federation, Ivachev E.A. ,   Penza State University, Penza, Russian Federation, Ivacheva O.T. ,   Penza State University, Penza, Russian Federation
Published: May 2024

Purpose. The study purpose was to identify risk factors that increase anterior segment inflammation after cataract surgery in patients with glaucoma. Material and method. We present 3 clinical cases in which anterior segment inflammation was observed after phacoemulsification in patients with combined cataract and glaucoma (with failure of the ligamentous apparatus of the lens, a history of anti-glaucoma surgery and the presence of a complete complicated cataract against the background of a narrow pupil). Results. In the first clinical case, descemetite was biomicroscopically observed on the next postoperative day; the intraocular fluid’s opalescence of the anterior eye chamber. This condition was the result of excessive manipulation during surgery (use of iris retractors and intracapsular ring). The vision on the first day was 0.4 does not correct (n/c), after 7 days it was 0.6 n/c. In the second clinical case, excessive contact with the iris (rupture of synechiae and action of instruments dilating the pupil) resulted in postoperative descemetis, dispersion of iris pigment in the anterior chamber moisture, residual viscoelastic on the endothelium. Vision on the first day after surgery was 0.2 n/c, on the 7th – 0.4 n/c. In the third clinical case, the descemetal folds were a consequence of increased ultrasound activity in a mature cataract as well as of manipulations that dilated the pupil. The day after surgery, visual acuity was 0.5 n/c. Conclusion. These clinical cases demonstrate risk factors of increased anterior segment inflammatory response after phacoemulsification for patients with combined cataract and glaucoma. They are: lens subluxation, previous trabeculectomy, complete complicated cataract and narrow rigid pupil. Key words: cataract, glaucoma, phacoemulsification, intraocular lens, cataract extraction, inflammation
A case of necrotizing scleritis that required plastic surgery for a wide conjuctival and scleral defects
Authors:   Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Takalandze L.M. , Kadyrov R.Z. ,   Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Orenburkina O.I. ,   Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Babushkin A.E. ,   Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation, Rakhimova L.R. ,   Russian Center for Eye and Plastic Surgery, Ufa, Russian Federation
Published: May 2024

The article presents a rare case of necrotizing scleritis in a 59-year-old patient at Russian Center for Eye and Plastic Surgery. The patient had suffered for six months from rheumatic episcleritis, complicated by keratitis, iridocyclitis and necrotizing scleritis that did not exclude the presence of Franceschetti – Bischler syndrome. Due to the refractive course and the development pf conjunctival and scleral necrosis, the patient underwent a surgical procedure at his local health facility – conjunctival repair with interrupted sutures. Unfortunately, within a week the conjunctival sutures came apart, given the large size of the conjunctival defect (1.1 sm ×4 mm), the patient underwent reoperation at the Russian Center for Eye and Plastic Surgery – surgical removal of necrotic tissue with the subsequent immobilization and conjunctival closure by allotendinous threads and interrupted sutures. Positive effect was observed. Key words:necrotizing scleritis, keratitis, iridocyclitis, Franceschetti – Bischler syndrome, surgical treatment, allotendinous threads.
Capital Control Taxes in an Emerging Market Economy
Authors: Karakoyun Oğuz Kaan
Published: May 2024

Historically, Emerging Markets (EMs) that own foreign debt and exhibit a high degree of dollarization have demonstrated vulnerability to a range of both real and financial shocks. Governments often use a range of capital control measures, particularly in nations burdened with external debt, with the aim of mitigating sudden swings in both inflows and outflows of capital. These policies are implemented to lessen exchange rate volatility and prevent dollarization. This study employs second moments analysis, impulse response functions and the welfare analysis to investigate the impact of a tax policy that restricts international capital flows on several macroeconomic variables in an emerging economy. A dynamic stochastic general equilibrium (DSGE) model is employed to examine the impact of the tax imposed on foreign borrowing on the economy, including both real shocks such as technology and growth, as well as financial shocks such as country risk premium. The findings of the study indicate that capital control taxes have a diminishing effect on the variability of significant macroeconomic variables, such as investment and consumption, when imposed at lower levels. Conversely, these taxes exhibit a stabilizing impact on the volatility of the trade balance-to-output ratio when implemented at higher levels. Moreover, quantitative evidence reveals that country risk premium shocks exert a substantial influence on variations in both the trade balance-to-output ratio and the level of investment, accounting for around 25% and 50% of the fluctuations, respectively. Finally, the existence of such a taxation enhances the intertemporal utility function at the steady state and reduces its volatility in the case of technology and growth shocks.
Public Education Investment, Economic Growth and Welfare: A Political Economy Analysis with Preference Heterogeneity
Authors: Doru Nusret
Published: May 2024

This study examines the politics of public education policy and its impact on economic growth and welfare under intergenerational altruism. The study considers an endogenous growth model with altruistic overlapping generations. Due to its significant role in promoting long-term economic expansion, we consider investment in public education to be an effective tool of productive government intervention. Nonetheless, public educational investment has been the subject of political disputes owing to its inherent intergenerational redistributive implications. Backed by the tendency of democratically elected governments to maintain their political power, the preferences of some particular individuals or group of individuals become more dominant in the political process of determining the level of public investment in education. In particular, governments are more concerned with the preferences of the median voter, or the current generation at large, because they, as electors, have the ability to determine the next government. This reality leads governments to exhibit a bias toward the desires of these people. As a result, such political considerations divert the economy from its optimal path of economic growth and reduce the welfare of future generations. This effect becomes more pronounced when individuals with lower levels of altruism toward their offspring assume a more influential position in the political decision-making process over the allocation of public funds for education. Our theoretical analyses demonstrate the implications for economic growth and welfare resulting from policy decisions made by democratically elected governments with inherent biases, as opposed to decisions made by an unbiased social planner.
Accelerating Density Matrix Embedding with Stochastic Density Fitting Theory – An Application to Hydrogen Bonded Clusters
Authors: Sun Yi
Published: May 2024

We demonstrate how using semi-stochastic Density Fitting (ss-DF) can accelerate self-consistent Density Matrix Embedding Theory (DMET) calculations by reducing the number of auxiliary orbitals in the three-indexed DF integrals. This results in time savings in building the Hartree Fock (HF) Coulomb and the Exchange Matrix and in integral transformation from the Atomic Orbital (AO) basis to the Embedding orbital (EO) basis. We then apply ss-DF to a range of hydrogen bonded clusters. First, we examine how the amount of deterministic space impacts the quality of the calculation in a (H2O)10 cluster. Next, we test the computational efficiency of ss-DF when compared to deterministic DF (d-DF) in water clusters containing 6 to 30 molecules of water using a triple-ζ basis set. Finally, we perform numerical structural optimisations on water and hydrogen fluoride clusters, revealing that DMET can recover weak interactions when using a back-transformed energy formula. This work therefore demonstrates the potential of using stochastic resolution of identity in quantum embedding theories and their potential to recover weak interactions.
Unlocking the Potential of Organopalladium Complexes for High-Grade Serous Ovarian Cancer Therapy
Authors: Scattolin Thomas , Cavarzerani Enrico , Alessi Dario , Mauceri Matteo , Botter Eleonora , Tonon Giovanni , Caligiuri Isabella , Repetto Ombretta , Kamensek Urska , Brezar Simona Kranjc , Dalla Pozza Maria , Palazzolo Stefano , Cemazar Maja , Canzonieri Vincenzo , Demitri Nicola , Nolan Steven Patrick , Gasser Gilles , Visentin Fabiano , Rizzolio Flavio
Published: May 2024

High-Grade Serous Ovarian Cancer (HGSOC) is the most common and lethal subtype of ovarian cancer, known for its high aggressiveness and extensive genomic alterations. Typically diagnosed at an advanced stage, HGSOC presents formidable challenges in drug therapy. The limited efficacy of standard treatments, development of chemoresistance, scarcity of targeted therapies, and significant tumor heterogeneity render this disease incurable with current treatment options, highlighting the urgent need for novel therapeutic approaches to improve patient outcomes. In this study we report a straightforward and stereoselective synthetic route to novel Pd(II)-vinyl and -butadienyl complexes bearing a wide range of monodentate and bidentate ligands. Most of the synthesized complexes exhibited good to excellent in vitro anticancer activity against ovarian cancer cells. Particularly promising is the water-soluble complex bearing two PTA (PTA = 1,3,5-triaza-7-phosphaadamantane) ligands and the Pd(II)-butadienyl fragment. This compound combines excellent cytotoxicity towards cancer cells with substantial inactivity towards non-cancerous ones. This derivative was selected for further studies on ex vivo tumor organoids and in vivo mouse models, which demonstrate its remarkable efficacy with surprisingly low collateral toxicity even at high dosages. Moreover, this class of compounds appears to operate through a ferroptotic mechanism, thus representing the first such example for an organopalladium compound.
Diisopropyl Methylphosphonate and Sarin Decomposition on Pristine vs. Hydroxylated Alumina Surfaces: Mechanistic Predictions from Ab Initio Molecular Dynamics
Authors: Biswas Sohag , Wong Bryan
Published: May 2024

Understanding the reactivity of chemical warfare agents on material surfaces is essential for mitigating and controlling their chemical/biological activity. Using \textit{ab initio} molecular dynamics, we compare the adsorption and decomposition of sarin and its simulant, diisopropyl methylphosphonate (DIMP), on both pristine and hydroxylated alumina surfaces at various temperatures. Our extensive calculations confirm that DIMP is a suitable simulant for sarin experimental studies on pristine alumina surfaces due to their similar adsorption configurations and reaction dynamics. Moreover, our ab initio molecular dynamics simulations predict C--O bond cleavage to be the initial decomposition step for both DIMP and sarin on the pristine surface. We also identify an additional potential decomposition route for sarin via cleavage of the P--F bond. While similarities exist on the pristine surface, differences between sarin and DIMP emerge on the hydroxylated surface at elevated temperatures. This work provides detailed insights into these atomistic decomposition mechanisms and highlights the utility of predictive quantum dynamics simulations for evaluating the suitability of simulants to guide future experimental investigations of these hazardous compounds.
Chemokine receptor hetero-oligomers regulate monocyte chemotaxis
Authors: Enten Garrett A , Gao Xianlong , McGee Michelle Y , Weche McWayne , Majetschak Matthias
Published: May 2024

It is known that stress influences immune cell function. The underlying molecular mechanisms are unclear. We recently reported that many chemokine receptors (CRs) heteromerize with α1-adrenoceptors (α1-ARs) through which CRs are regulated. Here, we show that arginine vasopressin receptor 1A (AVPR1A) heteromerizes with all human CRs, except chemokine (C-X-C motif) receptor (CXCR)1, in recombinant systems and that such heteromers are detectable in THP-1 cells and human monocytes. We demonstrate that ligand-free AVPR1A differentially regulates the efficacy of CR partners to mediate chemotaxis and that AVPR1A ligands disrupt AVPR1A:CR heteromers, which enhances chemokine (C-C motif) receptor (CCR)1-mediated chemotaxis and inhibits CCR2-, CCR8-, and CXCR4-mediated chemotaxis. Using bioluminescence resonance energy transfer to monitor G protein activation and CRISPR/Cas9 gene-edited THP-1 cells lacking AVPR1A or α1B-AR, we show that CRs that share the propensity to heteromerize with α1B/D-ARs and AVPR1A exist and function within interdependent hetero-oligomeric complexes through which the efficacy of CRs to mediate chemotaxis is controlled. Our findings suggest that hetero-oligomers composed of CRs, α1B/D-ARs, and AVPR1A may enable stress hormones to regulate immune cell trafficking.
Analisis Dampak Globalisasi Sebagai Dasar Penentuan Arah Kebijakan Pendidikan di Sekolah
Authors: Nanti Sri , Fadriati Fadriati
Published: May 2024

Abstrak. Menghadapi era globalisasi sekolah sebagai penyelengara pendidikan dipandang perlu merumuskan kebijakan pendidikan agar proses pendidikan yang dilakukan tetap relevan dan mampu menjawab kebutuhan zaman. Penelitian ini bertujuan untuk melihat bagaimana sebuah lembaga pendidikan menentukan arah kebijakan pendidikannya sebagai sebuah respon terhadap kehadiran era globalisasi. penelitian ini adalah deskriptif kualitatif atau dengan metode studi library research yang dikembangkan berdasarkan hasil pengamatan di lapangan. Hasil dari kajian ini menyimpulkan bahwa Kebijakan pendidikan dalam sebuah lembaga pendidikan dapat menjadi titik awal untuk memulai langkah pembaharuan. Kebijakan pendidikan sejatinya lebih komprehensif serta tepat guna sehingga benar-benar efektif untuk dilaksanakan.
Analisis Dampak Penggunaan Atribut Keagamaan terhadap Pola Persepsi Konsumen Muslim di Pasar Banyuasri, Buleleng
Authors: Idris Muhammad , Pradana Mahir
Published: May 2024

This article aims to understand the influence of religious attributes on the perception patterns of Muslim consumers as a basic basis for determining intentions to make choices based on religious symbols in the Banyuasri market, Buleleng, Bali. This study uses a phenomenological study method with a qualitative approach with descriptive data analysis. The results of the study show that religious attributes have a significant impact on the perception patterns of Muslim consumers in the Banyuasri market. Muslim consumers have a tendency to make choices based on consideration of strong religious symbols, such as headscarves, caps, and the use of daily symbols in the form of canang for Balinese Hindus. The strength of symbolic capital, especially in the use of religious attributes, can be an important factor in understanding the preferences and decisions of Muslim consumers in trading activities. Muslim consumers in Singaraja have a tendency to consider everything based on the main religious aspect in determining the choice of products and services they will buy.
Analisis Struktural Interpretatif untuk Merancang Transformasi Digital Pendidikan Tinggi di Indonesia
Authors: Vierke Intan Maria Lewiayu , Syarief Rizal , Fahmi Idqan , Sailah Illah
Published: May 2024

Penelitian ini menggunakan pendekatan Interpretive Structural Modeling (ISM) untuk merancang model yang akan digunakan dalam upaya transformasi digital pendidikan tinggi vokasi di Indonesia. Studi empiris dilakukan di Politeknik Negeri Bandung sebagai bagian dari pendidikan tinggi. Temuannya mengungkapkan bahwa Penemuan dan Penemuan, Desain Pembelajaran, Pengalaman Pelajar, serta Pekerjaan dan Pembelajaran Seumur Hidup merupakan elemen kunci yang saling terkait dalam konteks pendidikan kejuruan. Temuan ini memberikan panduan untuk mengoptimalkan program, strategi pemasaran, desain kurikulum, dan pengalaman pembelajaran untuk meningkatkan keterlibatan industri, daya saing lulusan, dan relevansi pendidikan dengan pasar kerja. Hasil penerapan ISM dan dampaknya dapat memberikan manfaat yang signifikan, termasuk peningkatan reputasi institusi, kepuasan mahasiswa, dan kontribusi positif terhadap perekonomian dan masyarakat Indonesia.
Konsep Merdeka Belajar dalam Perspektif Filsafat Pendidikan Aliran Esensialisme
Authors: Solihah Siti Nurhayati , Nurislamiah Siti , Kurniawan Ade Fakih
Published: May 2024

Filsafat esensialisme adalah kritik terhadap pendekatan progresif terhadap pendidikan, yang menekankan pelestarian warisan budaya. Meski tidak berdiri sendiri, esensialisme menimbulkan kekhawatiran akan ketidakpastian dalam pendidikan. Kebijakan didasarkan pada tujuan yang diharapkan dan teknologi mempengaruhi pemikiran dan perilaku manusia. Indonesia mengadopsi “pembelajaran gratis” dalam kurikulumnya untuk menjadikan pembelajaran lebih menarik dan mengintegrasikan teknologi untuk memecahkan masalah sosial. Metode penelitian yang digunakan dalam penelitian ini adalah analisis literatur. Tujuan penelitian ini adalah untuk mendeskripsikan pemahaman mendalam tentang konsep belajar mandiri dalam perspektif esensialisme. Hasil kajian dalam penelitian ini adalah terdapat kesesuaian pandangan filsafat esensialis ini dengan kurikulum Merdeka, dan menunjukkan bahwa esensialisme sebagai filsafat pendidikan berperan dalam memberikan landasan bagi pengembangan kebijakan desain ulang kurikulum Merdeka.
Analisis Rancangan Modul Ajar Kurikulum Merdeka Kelas I Pendidikan Pancasila Sekolah Dasar
Authors: Febby Mandalika Wayan Pudma , Priyanti Bekti Ayu , Puspitasari Lutfiana Maya , Purwani Meiriskha Ari , Sundari Niken Dwi , Ika Susanti Maria Melani
Published: May 2024

Penelitian ini bertujuan untuk mendeskripsikan hasil desain modul analisis pembelajaran kelas II Kurikulum Merdeka. Metodologi yang digunakan dalam penelitian ini adalah deskriptif kualitatif. Sumber data utama yang dijelaskan adalah komponen isi modul pengajaran kurikulum mandiri kelas II siswa sekolah dasar. Modul ajar PPKn Kelas II 2021 digunakan sebagai sumber data pembelajaran. Guru masih kurang baik dalam menyusun tujuan pembelajaran dengan menggunakan aspek ABCD yang lengkap dan menggunakan kata kerja operasional yang sesuai. Trigger question yang dibuat guru belum mampu menumbuhkan berpikir kritis pada siswa. Modul terbuka yang telah memuat guru memuat kegiatan pembelajaran yang runtut, terperinci dan sistematis. Namun belum ada perkiraan waktu yang jelas untuk setiap titik kegiatan. Modul ajar yang telah disiapkan guru sudah sesuai, terdapat rubrik penilaian kerja bagi siswa, baik penilaian individu, kelompok, penilaian sikap, dan penilaian keterampilan. Namun, belum ada bagian penilaian yang menunjukkan jenis-jenis penilaian penilaian. Remedial dan pengayaan tidak sesuai dengan program remedial dan pengayaan karena tidak mencantumkan langkah-langkah program seperti mengidentifikasi masalah, menyusun rencana sesuai masalah, melaksanakan remedial dan pengayaan, melaksanakan nilai, dan menentukan nilai akhir. Dengan demikian, dapat disimpulkan bahwa guru masih mengalami kesulitan dalam menyusun modul pengajaran.
Optimizing the Role of BNPT in Preventing Terrorism Financing Using Cryptocurrency in Indonesia
Authors: Ariani Okta , Ibrahim Aji Lukman
Published: May 2024

The development of cryptocurrency technology is the latest innovation in the financial sector. The purpose of this study is to determine the efforts made by BNPT and to assess the ideal regulations in addressing this issue in the future. Through the use of blockchain technology, users can transact anonymously. This research is considered as a normative juridical research equipped with interviews using a statutory approach. Sources of data obtained from secondary data which includes primary, secondary, and tertiary legal materials.  The novelty of the study shows that the BNPT establish the CTF Task Force which aims to combat terrorism financing through cryptocurrency and based on several previous studies and after looking at the above-mentioned examples of the phenomenon of terrorism financing, it is undeniable that many terrorists are trying to utilise cryptocurrencies to fund criminal acts. This has resulted in the issue of a legal or regulatory vacuum regarding the use of cryptocurrencies, in this case, the Commodity Futures Trading Supervisory Agency Regulation No. 6/2019 on Implementation of Anti-Money Laundering and Terrorism Financing Prevention In its future endeavors, there is a need for specific regulations to ensure that the implementation process of the CTF Task Force with other agencies can be carried out more optimally.
IoT based antenna positioning system
Authors: Mohammed Abdul Salam , Mohammad Arshad Ali , Suresh Palarimath , Mohammed Maqsood
Published: May 2024

Antennas are fundamental to every form of wireless communication system. Antenna placement is crucial for successful wireless communication, according to satellites and transmitters. So, to enable the use of IoT for remote antenna deployment, this paper provides an IoT-based antenna placement solution. In this case, this paper examines the transmitted orientation of each antenna over the Internet of Things using a sensor-based system that includes a motor on each antenna. When a satellite's or transmitting station's orientation changes, it is necessary to reposition the antenna. The receiving antennas might be located in different parts of the world, at great distances from each other. So, extremely long-distance antenna placement is within the realm of possibility because of modern technology. Online visibility of antenna sites is available to the operator in charge of the IoT. The antenna monitoring GUI system is utilized by the IoT. With IoT-based antenna placement solution technology, the antenna's orientation can be monitored and updated coordinates provided to the motor, allowing it to position the antenna correctly.
Production of trans-fat-free margarine prepared using catfish oil and palm
stearin with the addition of avocado waste oil for tocopherol enrichment
Authors: Widowati D. , Pangastuti A. , Ariviani S.
Published: May 2024

Catfish oil (CFO) is rich in unsaturated fatty acids (UFA) which are potentially produced
into margarine through the blending method with palm stearin (PS) addition. The high
UFA content of CFO causes margarine to be susceptible to oxidative damage, which can
also trigger the formation of trans fatty acids (TFA). An antioxidant compound in the form
of avocado waste oil (AWO) that contains tocopherol is added during margarine
production to inhibit oxidative damage and TFA formation in the final product. Thus, the
temperature and duration of CFO extraction, avocado peel and seed ratio of AWO
extraction, and CFO:PS:AWO ratio of margarine production were analyzed for their effect
on CFO, AWO, and margarine characteristics. This study was conducted by several
stages; CFO extraction with temperature (50, 70 and 90oC) and duration (1 and 2 hrs)
treatment, AWO extraction with avocado peel and seed ratio treatment (100:0, 75:25,
50:50, 25:75, 0:100), and margarine production with CFO:PS:AWO ratio treatment
(41:40:0, 36:40:5, 31:40:10, 26:40:15, 21:40:20). The results showed that the increasing
extraction temperature and duration caused the decrease of CFO hydrolytic-oxidative
stability. The best CFO extraction treatment was 50oC and 1 hr of extraction. The
increasing avocado peel ratio in AWO extraction led to the increase of AWO antioxidant
potential. The best AWO extraction treatment was the ratio of peel:seed = 75:25. The
addition of AWO in margarine production for tocopherol enrichment was proven to
suppress oxidative damage and TFA formation. The best margarine production treatment
was the 3rd formulation (10% of AWO) with UFA-rich and trans-fat-free margarine
characteristics. It was selected as the most preferred color, taste and flavor of margarine.
These studies’ results are beneficial for the product development of UFA-rich and transfat-free margarine with good oxidative stability prepared using freshwater fish oil and
plant byproduct oil.
RAZÕES E POSSIBILIDADES INFERENCIAIS PARA ESTUDOS DE CASO
Authors: Da Cunha Rezende Flávio
Published: May 2024

Este trabalho discute razões fortes para justificar o status inferencial dos estudos de caso na Ciência Política, de modo geral, e, em particular, na análise de Políticas Públicas. Casos podem ser justificados a partir de quatro razões: equifina-lidade; heterogeneidade causal; contrafactuais; e, por fim, a análise de mecanismos/ sequências causais, que são formas de lidar com o “Problema da Complexidade”, usual na análise de Políticas Públicas. O artigo oferece uma tipologia original — o Modelo KSTC — que se volta para entender os quatro elementos constitutivos dos estudos de caso conquanto desenhos de pesquisa: a Contingência (K), Substân-cia (S), Teoria (T) e Causação (C). A qualidade inferencial depende fortemente de como esses elementos são configurados, articulados nos desenhos de pesquisa, e tal combinação é decisiva. Na parte final, é sugerida a existência de um critério efetivo para a confecção de casos compreendidos conquanto desenhos de pesquisa.
BUTLER, JUDITH. A FORÇA DA NÃO VIOLÊNCIA. 1. ED. SÃO PAULO: BOITEMPO, 2021
Authors: Gesteira Sales Torres Geovane , Dos Santos Leite Maria Laís
Published: May 2024

Resenha do texto: BUTLER, Judith. A força da não violência. São Paulo: Boitempo, 2021.
Apresentação
Authors: Vasquez Vitor , Arquer Monize
Published: May 2024

Apresentação
Financiamento de campanha e êxito eleitoral nas eleições de 2016 e 2020 na Bahia
Authors: Rangel Barbosa Alan , Miceli Kerbauy Maria Teresa
Published: May 2024

O foco desta pesquisa é o Estado da Bahia e tem como objetivo observar se há associação entre sucesso eleitoral e despesa de campanha, dos partidos políticos dos candidatos a prefeitos e a vereadores, em 2016 e 2020, sem o aporte do financiamento empresarial de campanha, de acordo com a Lei 13.165/2015. Será também observado o papel do Fundo Eleitoral de Financiamento de Campanha, aprovado em 2017, por meio da Lei nº 13.487, de 6 de outubro de 2017, que foi aprovado com o objetivo de minimizar o impacto do fim dos recursos privados empresariais no financiamento de campanha. O Fundo aprovado é composto de dotações orçamentárias da União e distribuído com maior montante aos partidos com mais representantes na Câmara Federal e no Senado. Nas eleições municipais de 2020, seu aporte foi de R$ 2.034.954.823,96, conforme dados oficiais do Tribunal Superior Eleitoral. A expectativa é de que o resultado da pesquisa possibilite entender o poder do financiamento de campanha do quarto maior colégio eleitoral do país, primeiro da região Nordeste e o quarto maior estado em número de municípios no Brasil, contribuindo com as pesquisas nas ciências sociais nessa região do país e ampliando os estudos sobre eleições municipais no Brasil. Historicamente, as pesquisas sobre financiamento e eleições municipais se concentram nas regiões sul e sudeste do Brasil. Especificamente em 2016 e 2020, as poucas pesquisas existentes tiveram um foco nos resultados absolutos dos municípios do país. Por fim, este texto faz uma reflexão sobre como o financiamento de campanha e seus desdobramentos empíricos e teóricos ajudam a pensar nos impasses relacionados ao aperfeiçoamento do sistema partidário e eleitoral do Brasil e do ideal de democracia.