bluuebunny/crossref_metadata_2025 huggingface dataset:
POPÜLİZMİN VE POPÜLİST SÖYLEMİN KRİZ DÖNEMLERİNDE DEMOKRATİK SİYASAL SİSTEME ETKİ DÜZEYİ ÜZERİNE BİR ARAŞTIRMA
Authors: Doğanay Taylan Can
Published: February 2025

Popülizmi inceleyen ilk teorik çalışmalar, kavramın siyasal, toplumsal ve ekonomik boyutlarını anlamaya yönelik geniş bir analitik çerçeve sunmuş ve popülizmi bir ideoloji, söylem veya siyasal strateji olarak ele almıştır. 20. yüzyılın ortalarına kadar, popülizm çoğunlukla tarihsel ve bağlamsal bir fenomen olarak incelenirken, alternatif yaklaşımlar kavramın genel özelliklerini sistematik bir şekilde analiz etmeye başlamıştır. Bu çalışma, popülizmi ve popülist söylemi ampirik ve pratik bulgulara dayalı olarak inceleyen çalışmaları içerik analizine tabi tutarak popülizmin dönüştürücü potansiyelini ve demokrasiyle karmaşık etkileşimini incelemektedir. Çalışmanın amacı ise, popülizmin ve popülist söylemin demokratik normlara meydan okumasını, bu meydan okumanın demokrasinin yapısal ve kurumsal dengeleri üzerindeki etkilerini değerlendirmek ve demokratik siyasal sistemin popülizm karşısındaki direnç kapasitesini tartışmaktır. Araştırma bulgularına göre popülizmin ve popülist söylemin demokratik siyasal sistemi etkisi, krizlerin farklı aşamalarında belirginleşmekte ve bu dönüşüm, sistematik olarak değerlendirildiğinde popülizmin siyasal sistemlerde nasıl bir devinim oluşturduğunu anlamak mümkün hale gelmektedir. Araştırma, bu süreçleri kriz başlangıcı, kriz dönemi ve kriz sonrası olmak üzere üç ana aşamada incelemiş ve popülizmin her bir aşamada farklı düzeylerdeki etkilerini araştırma kapsamında ortaya koymuştur.
Assessment of Adherence to Hygiene and Asepsis Protocols in the Dentofacial Orthopedics Department, Ibn Rochd University Hospital Center, Casablanca, Morocco
Authors: Bouchghel Lamia , Mabrak Asmaa , Rbib Oumaima , Hamza Mouna , Alami Sanaa , Quars Farid
Published: February 2025

Introduction: Dental practice is a focal point for cross-contamination, where dental surgeons and their assistants engage in daily activities posing infectious risks to both patients and themselves. Adhering to universal hygiene and asepsis recommendations is a professional, regulatory, and ethical obligation. This study aims to evaluate the attitudes and behaviors of practitioners in the orthodontics department of CCTD Casablanca,Morroco regarding hygiene and asepsis.

Methods: A quasi experimental study was conducted through passive observation of orthopedics practitioners at the dental consultation and treatment center (CCTD) at Ibn Rochd University Hospital Center (CHU) in Casablanca. Data were collected on evaluation sheets based on universal hygiene and asepsis recommendations. The study included an initial assessment period, a focus group trainingand a reassessment period Data were analyzed using descriptive and analytical statistics via SPSS.

Results: The results align with international studies, showing that practitioners do not fully comply with regulations concerning work attire, hand hygiene, work surface disinfection, or waste management. Additionally, no statistically significant difference was observed before and after training (p≥0.01).

Discussion: The study assessed the adherence of practitioners in the dento-facial orthopedics service to hygiene and asepsis guidelines, emphasizing the need for continuous training and the use of guides to maintain proper standards. It found significant improvements in practices such as hand washing, attire changing, and mask usage post-training, although initial adherence was often lacking.

Conclusion: Despite some persistent challenges, the study highlights the importance of regular monitoring and training in enhancing infection control measures.
Phage Therapy: Past، Present and Future
Authors: Fathi Farzaneh , Zeinoddini Mehdi
Published: February 2025

Introduction: As viral agents، phages serve a significant purpose in molecular biotechnology. These viruses are considered as ideal tools in this field and recent studies revealed their wide potential in biomedicine. Research on phages showed that these viruses have the potential to develop new treatments، encompassing phages as anti-cancer solutions، transporters of imaging substances، tissue repair، medication distribution، vaccine formulation، and addressing COVID-19. The bactericidal effect of phage via CRISPR-Cas technology is also used to treat antibiotic-resistant bacteria. In this review study، we will explore the key role of phages in the research and development of future treatments.
Conclusion: Phages have arisen in the field of bioengineering with great potential in tissue engineering، vaccine development، and immunotherapy. The genetic composition of phages can be utilized to develop new vaccines and antigen display systems. Phages have opened new opportunities to target specific molecular determinants of cancer cells.
Comparison of the Effect of Resistance, Swimming, and Combination Training Patterns on Bone Density in Female Osteoporotic Rats
Authors: Zeidabadi Fatemeh , Banparvari Maryam , Mohammaddoost Omid
Published: February 2025

Introduction: The aim of the study was to compare the effects of resistance, swimming, and combined training patterns on L5 vertebral mineral density in osteoporotic rats.
Methods: In this experimental study, 36 female Wistar rats, each weighing between 170-190 grams, were selected as samples. To verify the induction of osteoporosis, 12 rats were randomly divided into two groups: healthy and alcohol-injected (6 rats). Osteoporosis induction was induced through intraperitoneal injection of a saline solution combined with ethanol over a period of 3 weeks. 24 rats were randomly divided into 4 groups (6 rats): 1. Resistance training, 2. Swimming training, 3. Combined training, and 4. Control. Swimming training (90 minutes per day, 5 days in 12 weeks) and resistance protocol (5 days in 12 weeks, each session 8 sets with 8-12 repetitions of climbing the ladder) and the combined group performed resistance training in 4 sets with 8-12 repetitions of climbing the ladder and swimming training with half the duration of the swimming group. After 12 weeks, samples were collected from the spine and the density of L5 was evaluated using a DEXA machine. Data were analyzed using independent t-test, one-way ANOVA, and Tukey's test with a significance threshold of less than 0.05 in SPSS-16 (P<0.05).
Results: In the intragroup comparison, resistance training and combined training significantly increased L5 density (P=0.00). In the intergroup comparison, L5 density of the combined group showed a significant increase compared to the training and control groups (P=0.00). The resistance group showed a significant increase in this variable compared to the swimming and control groups (P=0.00).
Conclusion: Using combined exercise as a therapeutic approach can increase bone density; therefore, it serves as an effective strategy for improving osteoporosis.
Efficacy of Emotion-Focused Therapy of Emotional Components in Women with Migraine Headache: a Clinical Trial Study
Authors: Nadushan Mozhgan Bakshi , Davodi Azam , Mirhosseini Hamid , Naziri Qasem
Published: February 2025

Introduction: Migraine disorder is a common psychosomatic disorder in which emotional and psychological factors are involved in its development. Emotion-focused therapy can be considered as an effective factor in the management of this disorder. The present study aimed to investigate the effectiveness of Emotion-focused therapy on emotional components in female patients with migraine.
Methods: It was conducted as a semi-experimental study featuring pre-test and post-test in two groups, one experimental and one control. The statistical population of the study comprised women experiencing migraine in Yazd City in 2024. Thirty patients were randomly assigned to two experimental and control groups. Prior to treatment, patients filled out the Emotional Belief Questionnaire (EBQ), Empathy Scale (PES), Depression, Anxiety and Stress Questionnaire (DASS-21) and Visual Analogue Scale (VAS); this assessment was made in the post-test phase. The length of the intervention period of emotion-focused therapy for the experimental group comprised 8 sessions of 90 minutes each, scheduled weekly. Data analysis was performed utilizing multivariate analysis of covariance and Statistical Package for the Social Sciences (SPSS) software version 16.
Results: The findings demonstrated that regarding emotional beliefs and their dimensions, as along with anxiety, depression, and stress, the group undergoing emotion-focused treatment had a significantly lower mean than the control group (P≤0.05). Regarding the empathy variable and its dimensions, all except for the ability to recognize negative emotions in others, the emotion-focused treatment group attained a significantly higher mean compared to the control group (P≤0.05).
Conclusion: The Research findings indicated that individuals with migraine headaches have difficulty experiencing and processing their emotions and experience worry and self-blame. Accordingly, the emotional therapy protocol is applicable for migraine patients and can successfully enhance the emotional aspects of these individuals.
Frequency of Polymorphisms of rs2274907 of Omentin Gene and rs9770242 of Visfatin Gene in Non-Alcoholic Fatty Liver Disease in an Iranian Population
Authors: Mohammadi Mahnaz , Saloki Neda kolivand
Published: February 2025

Introduction: Non-alcoholic fatty liver disease is the most common chronic disease, frequently occurring in various instances; if left undiagnosed and untreated, it will progress to cirrhosis and, in some cases, result in death. This disease is related to obesity, high blood pressure, metabolic syndrome and diseases and treatment. The Omentin gene consists of 8 exons and 7 introns, producing a protein made up of 313 amino acids. Visfatin is another adipokine. The Visfatin gene is located on the big arm of chromosome 7. The purpose of this study was to investigate the relationship between rs2274907 omentin and rs9770242 visfatin polymorphisms with non-alcoholic fatty liver disease in an Iranian population.
Methods: This study was carried out through a case-control study involving 70 patients with non-alcoholic fatty liver disease and 70 healthy individuals. The level of fasting blood sugar, triglyceride, cholesterol, HDL, and LDL was measured by standard methods; the amount of Omentin was measured with an ELISA kit. Genotype was determined by PCR-RFLP method. The data were analyzed by SPSS software version 16.
Results: The two investigated groups showed a significant difference in terms of age, BMI, LDL, HDL (P<0.05). The levels of triglycerides, omentin and average body mass profile were higher in the individuals with NAFLD; the level of HDL-C was lower than healthy individuals. Omentin had a significant relationship with the body mass level of LDL-C and HDL-C.
Conclusion: The current research demonstrated a notable connection between omentin and non-alcoholic fatty liver disease. This polymorphism of rs2274907 in the omentin gene has a significant relationship with non-alcoholic fatty liver disease.
PROJETO OUT OF THE BOX
Authors: Domingues Bruna Rabelo Ribeiro , Bento Ana Gabrielle Marques Reis , Braga Letícia de Carvalho , Oliveira Sarah Evellin de , Souza Isadora Reis , Bento Letícia Bianca Pereira , Santos Andrew Kenny , Sandrini Mariana Clepf , Benedito Julia Beatriz Verdolin , Marini Sophia Nery , Paes Jéssica Silva , Barcelos Larissa Stephany , Carvalho Leonardo César
Published: February 2025

O projeto Out Of The Box emergiu como uma resposta à necessidade de oferecer um espaço de reflexão e discernimento crítico no meio digital. Consiste em um podcast, veiculado a plataformas digitais. Durante sua realização, foram realizados dez encontros, totalizando 3.321 visualizações, com uma média de 332 visualizações por cada encontro. Observou-se boa adesão dos ouvintes, além de promover reflexões sobre temas variados, contribuindo para que estes atinjam uma visão mais ampla dos contextos sociais e de sua própria realidade.
EXPERIÊNCIAS NA FORMAÇÃO INICIAL DE DISCENTES NO PROJETO CONTAÇÃO DE HISTÓRIA
Authors: Silva Ranaísa Braga da , Próspero Hítalo Silva , França Kédhyma Cabral , Araujo Hilda Mara Lopes
Published: February 2025

O presente artigo objetivou proporcionar vivências da realidade profissional no ambiente escolar a partir do Projeto “Uma viagem no mundo do ‘faz de conta”: contar histórias como intervenção socioeducativa a partir do imaginário infantil”. Articulou-se ao processo formativo nas etapas da Educação Infantil e Anos Iniciais do Ensino Fundamental, guiou-se pela abordagem qualitativa, e os resultados alcançados proporcionaram aprendizados para a profissão do ser professor, em destaque para: planejamento, práticas pedagógicas.
VIP
Authors: Carvalho Anna Renata Góes , Oliveira Beatriz Victória Ramalho , Pires Cariston de Souza , Carvalho Celia Maria da Silva
Published: February 2025

O presente artigo aborda a importância da atividade do PET-Comunicação Social “Programa de Visitas para os Públicos Interno e Externos da UFAM - VIP” no fortalecimento da imagem institucional da Universidade Federal do Amazonas (UFAM) afim estreitar a relação entre a organização e a sociedade pelo acesso à ambiência institucional nos contextos local, nacional e internacional. Entre os resultados destacados incluem-se as ações e as atividades desenvolvidas por docentes, técnicos administrativos e discentes.
VIVÊNCIAS EM FITOTERAPIA EM UM CENTRO DE IDOSOS NO INTERIOR DA PARAÍBA
Authors: Gomes; Viviany Azevedo , Angelino Êmilly Mendes , Santos Joana Ferreira dos , Medeiros Beatriz de Freitas , Farias Samille Spellmann Cavalcanti de , Silva Yasmin Vitória Jó da , Pontes Denilson Clementino de , Souza Thainá Barbosa de , Almeida Laura Santos de , Silva Juliana Emily de Lima , Amorim Mayara Fernandes de , Ribeiro João Paulo de Queiroz , Jordão Ana Janaína Jeanine Martins de Lemos
Published: February 2025

As hortas comunitárias consistem no plantio de vegetais para fim alimentício e/ou medicinal. O objetivo deste trabalho foi relatar experiência em implantação de horta em Centro de Convivência de Idosos. Os desafios vivenciados foram: resistência dos funcionários, limitações físicas dos idosos no processo de manejo, manutenção ineficiente e inviabilidade dos vegetais. Observa-se que a implantação não obteve êxito e que, para garantir o sucesso desta, é necessário preparo da equipe de funcionários, bem como envolver o público nas atividades.
Contribuições das atividades do grupo PET Agroflorestal para a formação discente no campus de Chapadão do Sul/UFMS
Authors: Pinto Breno Selles , Rios Bruna Diniz , Soares Eduarda Santana , Boff Evelyn Gabrielly , De Lacerda Evelyn Rodrigues , Ganassim Fernanda , Devolio Gabriel Augusto Teixeira , Da Silva Grazielle Nogueira , Da Silva Guilherme Souto , Sabino Gustavo Casadei , De Medeiros Kayky Gomes , Freitas Lais Carla Souza , Flach Lilian Carine , Hayashi Maria Giulia , Konai Mauro Seyji Zanelli , Cordeiro Meire Aparecida Silvestri , Dos Santos Rubia Beatriz Silveira
Published: February 2025

O PET Agroflorestal, do Campus de Chapadão do Sul da Universidade Federal de Mato Grosso do Sul (CPCS/UFMS), realizou 20 atividades de Ensino, Pesquisa e Extensão durante o primeiro semestre de 2023. Dessa forma, ao término do semestre, foi formulado um questionário com perguntas sobre as atividades. Foram obtidas 52 respostas, que representa 10% do total de discentes com matrículas ativas dos cursos. Conclui-se que as atividades promovidas ou apoiadas pelo grupo PET Agroflorestal foram importantes para a integração, formação e para desenvolvimento pessoal e profissional discente no Campus de Chapadão do Sul, refletindo em permanência estudantil.
Explorando letramentos através de oficinas pedagógicas no simpósio de letramento para a cidadania
Authors: Maria de Souza Elayne , Gama da Silva Gemeson , Felipe de Barros José , Alves da Silva Juliana , Eduarda Oliveira da Silva Maria , Vinícius dos Santos Alves Ferreira Marcus , Fernanda Marques de Miranda Sousa Marielle , Mirella da Silva Rayne , Do Nascimento França Sthefany , Diana da Silva Correia Thayná , Augusto Alves dos Santos Otávio
Published: February 2025

O trabalho destaca a importância de um ensino-aprendizagem contextualizado e do letramento efetivo, utilizando oficinas pedagógicas como ferramenta para a educação de estudantes da educação básica. As oficinas, desenvolvidas pelo grupo PET Conexões de Saberes: Práticas de Letramento, serão aplicadas na X Edição do LECID em Recife-PE, com foco em estudantes de meios populares. Baseado em teóricos como Geraldi, Kleiman e Soares, espera-se que os participantes desenvolvam habilidades de letramento, promovendo cidadania e uma educação crítica e reflexiva
Palavra-poema: um estudo de caso sobre rimas de rappers femininas
Authors: Adrielle Almeida Ladislau Luyana , Machado Morais Johnatan , Farias da Silva Franciane , Cristina Geraldes Elen
Published: February 2025

O estudo analisa a produção discursiva do RAP de mulheres negras da RIDE-DF e uma indígena de São Paulo, explorando interseccionalidade e afetos em suas letras. Utilizando o software Iramuteq, foram geradas nuvens de palavras e árvores de similitude, revelando temáticas como ancestralidade, empoderamento feminino e a busca por uma vida simples e melhor. As músicas abordam lutas sociais, sabedoria ancestral e afetividade, distanciando-se do estigma do RAP. O empoderamento transforma suas realidades e contribui para a valorização do conhecimento tradicional e feminino.
Projeto “UFRGS para todos”
Authors: Vinicius de Souza Teixeira Marcos , Matheus do Nascimento de Andrade Vitor , Heinz Costa Francisco , Correa da Rosa Andrio , Ferreira Nieto de Sousa Eduarda , Thalya Pilar Steyer da Silva Victória , Gabriel Bermudez Dieterich João , Melo Pacheco Gabriel , Schuh Carlos , Alberto Ruver Cesar
Published: February 2025

O projeto de extensão “UFRGS para Todos”, desenvolvido pelo Grupo PET Engenharia Civil, atua em escolas públicas de ensino médio, apresentando a UFRGS e formas de ingresso nas universidades públicas (ENEM e vestibular) por meio de atividades de integração e dinâmicas lúdicas. Realizado em encontros presenciais, o projeto visa (a) aproximar estudantes de escolas públicas da universidade, (b) fornecer informações muitas vezes inacessíveis, (c) responder dúvidas sobre o ingresso e (d) incentivar o acesso às Universidades Federais.
Processos seletivos do programa de educação tutorial
Authors: Das Dores Nogueira de Oliveira Marina , Beatriz Lima de Andrade Anna , Paiva da Silva Bruna , De Paula Silva Cremilson , Aparecida Leonel Gabriela , Borelli Oliveira Gabriela , Antônio Gonçalves Ribeiro Guilherme , Augusta Brandt Paiva Maria , Helen Gonçalves Martins Mariana , Cristina Martins Silva Pamela , Gabriel de Oliveira Silva Paulo , Raabe de Oliveira Savana , Gonçalves da Silva Taline , Cristina Silva Vitoria , Vieria da Silva Yasmin , De Cássia Lopes Chaves Érika
Published: February 2025

O Processo Seletivo do PET/Enfermagem é necessário, envolve reflexão sobre requisitos e procedimentos para ingresso. O artigo trás o relato de experiência dos membros do grupo, com questionário sobre três opções realizadas entre outubro de 2021 e junho de 2023. Seu formulário destacou opiniões sobre o modo de avaliação, sugestões de melhoria e dificuldades. Os processos foram criteriosos, buscando estudantes proativos, com potencial e habilidades, formando um grupo diversificado e apto para as atividades do PET.
"Przez zarzuconą subtelną bawełnicę…" – cognitio symbolica w kazaniach reformata Antoniego Węgrzynowicza (źródła, zastosowania i konteksty)
Authors: Kuran Magdalena
Published: February 2025

Przedmiotem rozprawy jest cognitio symbolica obecna w twórczości kaznodziejskiej reformata Antoniego Węgrzynowicza. Przejawia się ona w posługiwaniu się przez autora strukturami symbolicznymi (tu senso largo, obejmującymi alegorię, metaforę i inne struktury oparte na analogii). W tytule pracy pojawiają się trzy terminy: źródła, zastosowania, konteksty. Tak więc „myślenie symboliczne” pokazane zostaje nie tylko jako technika twórcza (zastosowania), ale opisane zostają także jego geneza (źródła) i towarzyszące mu, nie zawsze oczywiste, konteksty. Na początku przybliżono sylwetkę Węgrzynowicza. Jego postać ukazano w nieco szerszym kontekście, m.in. rodu, z którego się wywodził, miasta, w którym się wychował, licznych umiejętności, które zdobył, oraz podejmowanych przez niego aktywności. W charakterystyce wykorzystano jego kazania, a także opinie współczesnych.
Estudio paisajístico de los aspectos biofísicos y antrópicos en dos espacios urbanos de la ribera del río Rímac en Lima, Perú
Authors: Santiváñez López Miguel Ángel , Núñez-Alberca Alejandro
Published: February 2025

El presente artículo tiene como objetivo describir y contrastar los aspectos biofísicos y antrópicos en dos espacios urbanos aledaños al río Rímac en la ciudad de Lima: el Malecón de la Amistad, y los miradores del antiguo proyecto Zona Reservada del Río Rímac. El enfoque es cualitativo, de alcance descriptivo, y recurre a los criterios de análisis paisajístico de Castillo et al. (2014) con miras a resaltar las formas de uso posibilitadas por la intervención antrópica en relación con el ecosistema natural. Los resultados sugieren que los espacios en cuestión han sido intervenidos con la finalidad de direccionar el desplazamiento de sus visitantes. Sin embargo, en ambos casos los elementos materiales de la escena urbana manifiestan una precaria integración entre lo biofísico y lo antrópico, lo cual da cuenta de un intervencionismo contradictorio que impone y cancela diversas formas de uso para los visitantes, agudizando la fragmentación espacial.
In vitro, Evaluate Effectiveness of Allium cepa Ethanol Extract in Inhibiting the Growth of Toxocara canis Eggs
Authors: Jasim Hussein Jabar , Abdulzahra Ibrahem A. , Rhaif Qasim A. , Alani Zaid Khalid , Kathem Ali Naser
Published: February 2025

Background: Toxocariasis is one of the most significant infectious disease that is caused by T.canis which primarily infect dogs. Dogs become infected by consuming contaminated food that contains either eggs or larvae (L2) encysted in the paratenic hosts. These eggs can resist harsh conditions. Methods: Investigating the effects of onions (Allium cepa) ethanol extracts at varying concentrations (5, 10, 20, 30 and 50 mg/ml) for periods of time (24 and 48 hours) against the unembryonated T. canis eggs growth in vitro was aimed of this study. The positive control group was Drontal® Plus, while the negative control was water. Result: Upon microscopic, the results indicated that eggs of T. canis treated with A. cepa extract in vitro are sensitive to the extract at different doses and that their activities are time- and concentration-dependent. The highest was observed at dosages of 30 and 50 mg/ml for 24 and 48 hrs. respectively, where the efficacy was 100%. At doses of 20 mg/ml, the extract shows 98.8 and 100% ovicidal efficiency for 24 and 48 hrs. respectively. When compared to the Drontal® Plus group and water group, which were 100 and 11.8%, respectively, the treated T. canis eggs with doses of 5 and 10 mg/ml of A. cepa extract demonstrated ovicidal activity at 24 and 48 hrs., by 88.4, 93.9, 94.3 and 98.6%, respectively.
JUDICIALIZAÇÃO DA SAÚDE E OS IMPACTOS ORÇAMENTÁRIOS EM MUNICÍPIOS DE FRONTEIRA INTERNACIONAL
Authors: Carvalho Manoela de , Mergener Solange de Fatima Corbolin
Published: February 2025

A busca por instituições judiciárias para obter acesso às tecnologias em saúde como medicamentos, procedimentos, produtos como prótese, alimento industrializado, leito hospitalar indisponíveis ao usuário, envolve custos para o SUS e traz consequências ao orçamento financeiro previamente planejado. Estudo com objetivo de analisar a judicialização da saúde e o impacto financeiro em municípios da 9ª Regional de Saúde do Paraná, desenvolvido a partir de dados secundários obtidos no site do Conselho Nacional de Justiça da amostra de 295 Notas Técnicas, de 2020 a 2022. Resultados mostram mais de 60% das ações judiciais favoráveis aos autores, a maioria movida para acessar bens e serviços já incorporados ao SUS, medicamento foi a tecnologia mais pleiteada, os preços variaram de R$ 21,78 a R$ 474.676,24. Oftalmologia e oncologia foram as especialidades médicas mais judicializadas. Conclui-se que o judiciário, ao buscar garantir direito a bens e serviços já prometidos e incorporados ao SUS, assegura o direito individual asseverado pela Constituição Federal, mas pode interferir no planejamento de ações de saúde voltadas ao coletivo. Sugere a possibilidade de contrapor à judicialização com ações de gestão do SUS com políticas de promoção da saúde e prevenção do adoecimento desde o primeiro nível de atenção à saúde e por meio da implementação de políticas sociais mais amplas e universais.
ANALISIS STANDAR KOMPETENSI PENGAWAS MADRASAH DI KANTOR WILAYAH KEMENTERIAN AGAMA DERAH ISTIMEWA YOGYAKARTA
Authors: Utami Fallya Putri , Rossy Liana Hikma  , Hanum Novariza Berliana  , Muhammad Zainal Abidin
Published: February 2025

Penelitian ini bertujuan untuk menganalisis implementasi standar kompetensi pengawas madrasah berdasarkan Peraturan Menteri Agama Nomor 2 Tahun 2012 di Daerah Istimewa Yogyakarta (DIY). Dengan menggunakan pendekatan kualitatif deskriptif, penelitian ini mengumpulkan data melalui wawancara mendalam, analisis dokumen kebijakan, dan laporan supervisi. Hasil penelitian menunjukkan bahwa penerapan standar kompetensi, yang mencakup aspek kepribadian, supervisi akademik, evaluasi pendidikan, penelitian dan pengembangan, serta kompetensi sosial, telah memberikan dampak positif terhadap kualitas pendidikan madrasah di DIY. Namun, tantangan seperti kekurangan jumlah pengawas, tingginya beban kerja, dan keterbatasan penguasaan teknologi masih menjadi hambatan utama. Untuk mengatasi kendala tersebut, berbagai inovasi, seperti penggunaan aplikasi Jogja Madrasah Digital, dan kolaborasi melalui kelompok kerja pengawas madrasah (Pokjawas), diterapkan. Penelitian ini memberikan rekomendasi untuk meningkatkan kualitas supervisi melalui pelatihan berbasis teknologi, peningkatan jumlah pengawas, dan penguatan kebijakan alokasi sumber daya.
MARTIN HEIDEGGER'S EXISTENTIALISM AS A PARADIGM IN ISLAMIC RELIGIOUS EDUCATION
Authors: Sutrisno Shidiq Agung
Published: February 2025

This research explores the application of Martin Heidegger's existentialist philosophy, especially the concept of Dasein, as a paradigm in Islamic Religious Education. This research examines how Heidegger's principles- self-awareness, freedom, and moral responsibility- can overcome the limitations of traditional dogmatic approaches in Islamic Religious Education, which often lack reflection. Using qualitative-descriptive methods and philosophical analysis, this research integrates Heidegger's existentialism with reflective pedagogy to offer an innovative teaching model. Data were collected through extensive literature observations and analyzed using qualitative content analysis, focusing on thematic reduction, categorization, and interpretation. Findings show that the existentialist approach fosters critical thinking and spiritual awareness, enabling students to authentically internalize Islamic values ​​and adapt them to modern challenges. This paradigm shifts the teaching of Islamic Religious Education.  from rote memorization to a dialogical method, increasing moral responsibility and authentic self-development. Despite challenges such as resistance from traditional educators and curriculum limitations, this research highlights the transformative potential of existentialism in forming reflective and morally mature students.
Sclerotic Bone Adversely Affects Anti-Tuberculosis Drug Distribution in Patients with Spinal Tuberculosis
Authors: Jiang Guanyin , Tang Yuchen , Xiang Shanlin , Wang Qiufu , Zhao Dezhang , Du Xing , Hao Jie , Hu Zhenming
Published: February 2025

Background:

The effects of sclerotic bone on anti-tuberculosis (anti-TB) drug distribution in the blood and in spinal tuberculosis (STB) lesions were investigated.

Methods:

Fifty-six patients with STB were prospectively enrolled from January 2020 to March 2023 and were divided into 2 groups: a group with sclerotic bone and a group without sclerotic bone, as identified on preoperative computed tomography (CT) scans. Individuals in the sclerotic bone group were further divided into fragmentary and non-fragmentary sclerotic bone groups. The patients underwent surgery, and blood was collected along with normal vertebral and STB-lesion-containing bone tissue samples. Following treatment, the samples were processed by a pharmacological laboratory in order to detect the concentrations of anti-TB drugs, including pyrazinamide, rifampicin, isoniazid, and ethambutol.

Results:

Twenty-seven East Asian female and 29 East Asian male patients with STB were included in this study. The levels of anti-TB drugs showed a progressive decrease with increased circulatory distance, from blood to normal vertebral tissue to TB lesions, across all patient groups. Drug concentrations in TB lesions in the sclerotic bone group were significantly lower than those in the non-sclerotic bone group, as were concentrations in TB lesions in the non-fragmentary sclerotic bone group relative to those in the fragmentary sclerotic bone group. Drug levels in the blood and in normal vertebral bone tissue did not significantly differ between the sclerotic and non-sclerotic groups, nor between the fragmentary and non-fragmentary groups. Drug levels in the blood were linearly correlated with those in TB lesions in both the non-sclerotic bone group and the fragmentary sclerotic bone group.

Conclusions:

These results indicate that sclerotic bone negatively affects the dissemination of anti-TB drugs, with non-fragmentary sclerotic bone posing a greater obstacle than fragmentary sclerotic bone. In patients with STB without sclerotic bone or with fragmentary sclerotic bone, anti-TB drug levels in the blood were linearly correlated with drug levels in STB lesions.

Level of Evidence:

Prognostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Overview of a rapid discrete infrared acquisition system and method for automated behavioral analysis of multiple emissive objects
Authors: Davis Austin
Published: February 2025

Many animal species form congregations on the landscape. These concentrations of animals provide an opportunity for biologists to conduct efficient population monitoring efforts. While general use of these sites is easy to document, continual monitoring is often problematic due to limited resources (time, expertise, etc.), potential for human disturbance on animal population and behavior, and an inability to determine an accurate assessment of counts. To allow for accurate and efficient assessment of animal numbers and usage of an area, an automated technology has been developed to monitor and characterize large animal concentrations. This automated technology provides information on population size, movement behavior characteristics, and other behavioral aspects of the target species.
What influences vocational college students’ actual use of mobile learning? An empirical study using the PLS-SEM method
Authors: Tan QI , Lin Xuefei , Li Wei , Xiong Bin
Published: February 2025

The vulnerable group of students in vocational institutions seems to have received insufficient attention in today's world of digital change. Thus, this study aimed to explore the factors influencing vocational college students’ actual use of mobile learning, and examine the moderating effect of gender. For this purpose, the technology acceptance model was adopted. There were 319 vocational college students from Liaoning (China), and these data were analyzed using a partial least squares structural equation modeling (PLS-SEM) method. The results showed that vocational college students’ behavioral intention positively and significantly affected their actual use of mobile learning. Based on the multi-group analysis, it was indicated that gender had a significant moderating effect on the relationship between perceived ease of use and perceived usefulness and attitude and behavioral intention. This study provides empirical evidence revisiting the rationality of the classic technology acceptance model. Additionally, the findings are also beneficial for the leaders and teachers in vocational college to promote students’ actual use of mobile learning in an era of global technological change.
Mass spectrometry-based thermostability profiling of virus-derived MHC peptide complexes serves as an effective predictor of immunogenicity
Authors: Purcell Anthony , Shahbazy Mohammad , Ramarathinam Sri , Tscharke David , Li Chen , Faridi Pouya , Croft Nathan
Published: February 2025

The major histocompatibility complex (MHC) encodes molecules that present peptides on the surface of cells to stimulate T-cell-mediated immune responses. The stability of peptide-MHC class I complexes (pMHCI) has been postulated to influence the immunogenicity of virus-derived epitopes and cancer neoepitopes. Here, we sought to investigate this further by conducting thermostability profiling of thousands of individual pMHCI, including a panel of 110 vaccinia virus (VACV) derived peptides with known CD8+ T cell response profiles. The denaturation profiles of these peptides spanned thermostability (Tm) ranges of 41.2°C to 65.1°C, and we found that thermostability correlated with immunogenicity in VACV-infected mice. We developed two machine learning-based models from these thermostability data to predict peptide immunogenicity and demonstrate the ability of this model to distinguish immunogenic epitopes derived from an unrelated infectious pathogen, influenza A virus in mice. Using such models, we provide evidence that the thermostability of pMHCI allows for improved prediction of immunogenic CD8+ T cell epitopes and conclude that this information is a valuable measurement for selecting optimal targets for T cell-mediated therapies and vaccine design.
Evaluation of the effect of biochanin b and Sorafenib on cell survival, growth, migration, colony formation and apoptosis in hepatocellular carcinoma
Authors: Abdolkarimi Hamed , Jafarinia Mojtaba , Sadeghi Hossein , Forouzanfar Mohsen
Published: February 2025

Background and Purpose: Formononetin is a phytoestrogen isolated from several medicinal plants, and it is extensively investigated for its anti-cancer effects in several cells. However, the impact of formononetin on hepatocellular carcinoma (HCC) has been unclear. In this study, the influence of formononetin on cell growth, metabolism, and signaling molecules is examined in the HepG2 cells, singly and in combination with sorafenib. This study investigates the individual and combined effects of formononetin and sorafenib on growth, metabolism, and signaling in HepG2 cells, focusing on miR-21 regulation and theirdownstream effects for the first time. This study underscored the dependent effects of the two drugs on the expression of miR-21. The drugs, either alone or together, indirectly affect the expression of other genes via miR-21 as well as directly. this study aiming to explore its molecular mechanisms and potential therapeutic values.
Materials and Methods: Materials and Methods: HepG2 cells were treated with formononetin, sorafenib, or a combination of both. cell growth, colony formation, migration, apoptosis, gene expression, and protein contents were investigated. Formononetin (1-640 µM) and sorafenib (0.01-64µM) or itscombination (0.01µM sorafenib+1µM formononetin) were tested.
Results: After 48 h, treatments reduced the cell viability and colony formation and induced apoptosis. miR-21 expression was significantly lowered by combination therapy which demonstrated the most potent inhibitory effect on EGFR, VEGF-A, MMP-9 expression, increasing BAD expression with the highest levels in the combination group, then sorafenib and followed by formononetin. Isolated compounds or their combination caused a reduction in survivin expression levels, with the least effect for formononetin and the most notable effect for combination treatment. Formononetin produced a more considerable reduction in the expression of EGFR and VEGF-A thansorafenib, but their combination caused the most prominent reductions.
Conclusion Formononetin is a promising compound as an adjuvant therapy for HCC, especially when used in combination with sorafenib. The combination therapy not only enhances the inhibition of key oncogenic pathways involved, such as EGFR, VEGF-A, and MMP-9, but also induces pro-apoptotic machinery by downregulating miR-21 and upregulating BAD expression. All these data suggest that formononetin, in combination with sorafenib, may present a more effective therapeutic approach againstHCC. More in-depth preclinical and clinical studies are needed to support the findings and establish its clinical applicability.
Clinical Outcomes of Pterygium Surgery Over a Ten-Year Period: A Review of Recurrence and Complication Rates
Authors: Noguera Sharlene I. , Nicanor Aniana Katherine S. , Ang Robert Edward T. , Cruz Emerson M.
Published: February 2025

Purpose
This study described the clinical profile and post-operative outcomes of patients who underwent pterygium surgery at an ambulatory eye center in the Philippines over a ten-year period.
Methods
This retrospective study analyzed medical records of 462 eyes from 408 patients who underwent pterygium surgery by a single surgeon between February 2013 and August 2023. The study examined the clinical characteristics of patients with pterygium and evaluated the recurrence rates of three treatment methods: pterygium excision with conjunctival autograft (CAG), pterygium excision with dehydrated amniotic membrane graft (DAG), and primary excision with mitomycin C application. Descriptive statistics were used for analysis of patient demographics, clinical profile, and postoperative outcomes.
Results
The mean patient age was 48 years (range 17–81), with a slight male predominance (57%). Nasal pterygium was the most common type (72%), followed by bipolar (8%) and temporal (3%) pterygium. Most cases were primary (81%), with T2G1 being the most common grading. Conjunctival autograft was the predominant surgical technique (94%), followed by dehydrated amniotic membrane graft (5%) and primary excision with mitomycin C application (1%). The overall recurrence rate was 1%, with conjunctival autograft showing the lowest rate, compared to dehydrated amniotic membrane graft and primary excision with mitomycin C. The complication rate was 4.5%, primarily minor findings such as conjunctival granuloma, wound dehiscence, and residual pterygium.
Conclusion
Most pterygium cases presented as primary and in the nasal area with T2G1 grading. This study supports conjunctival autograft as the preferred surgical technique for pterygium because of the low recurrence and complication rates.
Repression of Connexin26 Hemichannel activity protects the Barrier Function of Respiratory Airway Epithelial Cells against LPS-induced Alteration
Authors: Lehrich Tina , Dierks Anne , Plenge Masina , Obernolte Helena , Grieger Klaudia , Sewald Katherina , Rodriguez Frederic , Malet Lucie , Braubach Peter , Bedos-Belval Florence , Ngezahayo Anaclet
Published: February 2025

In respiratory airway epithelial cells lipopolysaccharide (LPS) treatment induced an enhancement of connexin 26 (Cx26) hemichannel activity shown by dye uptake experiments combined with siRNA knock-down of Cx26. This effect was already observed at infection relevant concentrations (≤ 10 ng/mL LPS) and involved tumor necrosis factor (TNF)-α- and Ca2+-dependent signaling. High concentrations (1 µg/mL LPS) reduced the transepithelial electrical resistance (TEER) of Calu-3 cells by 35 % within an application time of 3 h followed by a recovery. Parallel to barrier alteration, a reduced tight junction organization rate (TiJOR) of claudin-4 (CLDN4) by 75 % was observed within an application time of 3 h. After TEER recovery, CLDN4 TiJOR stayed reduced. Low concentrations (10 ng/mL LPS) required three times repeated application for barrier and CLDN4 TiJOR reduction by 30 %. The small molecule CVB4-57, newly published as a potential inhibitor of Cx26 hemichannels, mitigated the effects of LPS on the epithelial barrier function. Molecular docking studies revealed a potential interaction between CVB4-57 and Cx26 thereby reducing its hemichannel activity. We conclude that LPS-related enhancement of Cx26 hemichannel activity acts like a “molecular scar” that weakens the lung epithelium, which could be attenuated by agent targeting the Cx26 hemichannels.
Complicated silicosis due to engineered stone: High metabolic activity in positron emission tomography and systemic inflammation years after exposure cessation
Authors: Antonio León-Jiménez , Julio Rodríguez-Rubio Corona , Gema Jiménez-Gómez , Luisa Piñero Fernández-Reyes María , Antonio Hidalgo-Molina , Magdalena Pajares-Vinardel , Ángel Conde-Sánchez Miguel , Antonio Campos-Caro
Published: February 2025

Engineered stone silicosis is an interstitial lung disease that progresses rapidly causing, in many cases, respiratory insufficiency and death. Metabolic activity in lungs and adenopathies and its relationships with systemic inflammation are unknown. Patients with complicated silicosis were enrolled. All had worked for at least 5 years in finishing and installing engineered stone and had ceased exposure for at least 7 years. Clinical data, positron emission tomography/computed tomography using 18F-fluorodeoxyglucose (18F-FDG PET/CT), respiratory function tests and blood samples were collected. Patients’ mean age was 44 ± 5.4 years. The average exposure duration was 10.94 ± 3.2. Years from cessation of exposure was 11.6 ± 1.6. The average maximum standardized uptake value (SUVmax) of large opacities was 6.32 ± 3. All patients presented hypermetabolic mediastinal lymphadenopathies and 88.2% also extrathoracic lymphadenopathies. SUV max of large opacities was correlated with Fibrinogen (ρ = 0.717, P = 0.001), lymphocyte-to-monocyte ratio (ρ = -0.506, P = 0.038), systemic inflammatory response index (ρ = 0.559, P = 0.02) and CD4 + NKT cells. Large lung opacities and lymphadenopathies showed high metabolic activity even years after silica exposure ended. The relationships between metabolic activity and some inflammatory factors open a pathway for exploring new therapeutic targets.
Thoracic paravertebral teratoma: a case report and literature review
Authors: Tao Benzhang , Gao Gan , Chen Cheng , Zang Jinfeng , Li Teng , Qiao Guangyu
Published: February 2025

Teratomas are among the most common germ cell tumors found in children. They predominantly occur in the sacrococcygeal region and often in the spinal canal, whereas paravertebral teratomas are very rare. Herein, we present a case of a paravertebral teratoma incidentally discovered in an 11-year-old boy. The tumor was located between the diaphragm, parietal pleura, ribs, and intercostal muscles. Complete resection was achieved using the paramedian approach. Postoperative recovery was uneventful, and no tumor residue or recurrence was observed at the 3-month follow-up. This case underscores the importance of considering teratomas in the differential diagnosis of paravertebral masses.
Revolutionizing UTI Treatment: Harnessing Ant Colony Optimization for Effective E. coli Combat in the Urinary Tract
Authors: Raikar Gokuldas (Vedant) S. , Raikar Amisha S. , Gururaj H.L. , Kumar Pramod , Somnache Sandesh N. , Sajanikar Atharva Y. , Hu Yu-Chen
Published: February 2025

This research presents a bio-inspired nanorobot swarming algorithm based on Ant Colony Optimization (ACO) for combating Escherichia coli (E. coli) in Urinary Tract Infections (UTIs). UTIs caused by E. coli are a major global health concern. An approach that mimics the collective behavior of ant colonies in foraging tasks, utilizing ACO principles to guide the navigation and targeting of nanobots within the urinary tract, was proposed. Using NetLogo, an agent-based modeling platform, simulation and evaluation of the nanorobot swarm's performance was carried out. The swarm consists of autonomous agents that mimic ant behavior, with E. coli bacteria as the target. The efficacy of the ACO-based algorithm in eradicating E. coli in UTIs was demonstrated through extensive experimentation. Experimental results show that the algorithm successfully guides nanobots to locate and neutralize E. coli bacteria, reducing infection levels. The investigation also investigated the impact of parameters like pheromone evaporation rates and agent communication strategies on swarm performance. This research contributes to nanorobot technology advancement and highlights the potential of bio-inspired algorithms for medical challenges. The proposed ACO-based algorithm offers a targeted and efficient approach to combat E. coli infections in UTIs. Insights gained from this study can guide further research and development of nanorobot-based therapies for urinary tract infections and other infectious diseases.
Late time to treatment initiation and its determinants among patients with colorectal cancer in Amhara region oncology centers a multicentered cohort study a multicentered cohort study, Ethiopia, 2024
Authors: Walle Getachew Tesfaw , Meshesha Seteamlak Adane , kitaw Tegene Atamenta , Dagnew Betelihem Walelgn
Published: February 2025

Introduction: - Colorectal cancer is a significant cause of mortality globally. Timely initiation of treatment colorectal cancer is crucial, as delays have consistently shown to worsen outcomes and decrease overall survival rates. Despite this, the specific factors affecting late time to treatment initiation among colorectal cancer patients in the Amhara region have not been thoroughly investigated.
Objective: - To assess the late time to treatment initiation and its determinants among patients with colorectal cancer in Amhara region oncology centers a multicentered cohort study, Ethiopia, 2024.
Method and Material: - A retrospective cohort study was conducted among 484 study participants who started follow-up from July 1, 2018, to June 30, 2023 in Amhara Region Oncology Centers. Data were entered into Epi-data V4.2 and exported to STATA V14 statistical software for analysis. Cox regression model was used to identify factors associated with the incidence of mortality. All variables with P-value < 0.25 and ≤ 0.05 bi-variable and multivariable Cox regression model were considered statistical significance respectively.
Results: - The mean age of the participants was 48 years (SD± 7). The median waiting times was 117 days [95% CI: 95, 150]. The result of the multivariable analysis showed that rural residence [AHR= 1.34, 95% CI: 1.00, 1.79], Baseline body surface area £1.78m2 [AHR= 2.48, 95% CI: 1.24, 4.96], Distance of treatment center >80km ([AHR=1.41, 95% CI: 1.06, 1.88] and start non chemotherapy regimens [AHR=1.35, 95% CI: 1.00,1.82] were significantly associated with delays time to treatment initiation.
Conclusion and recommendation: - The median waiting times was very high than previous study. Address rural residence, Baseline body surface area £1.78m2, Distance of treatment center >80km and start non chemotherapy regimens were imperative for optimizing survival outcomes. Government level managers enhancing health care facilities are crucial. Researchers, focus on factors like lifestyle, genetics and treatment quality.