bluuebunny/crossref_metadata_2025 huggingface dataset:
Asymptotic profile of a mutualistic model on a periodically evolving domain
Authors: Adam Badradeen , Lin Zhigui , Tarboush Abdelrazig K.
Published: August 2019

In order to investigate the impact of periodically evolving domain on the mutualism interaction of two species, we study a mutualistic model on a periodically evolving domain. To overcome the difficulty caused by the advection and dilution terms, we transform the model to a reaction–diffusion problem in a fixed domain. By means of eigenvalue problems, the threshold parameters are introduced. The asymptotic profiles of the solutions on an evolving domain are studied by using the threshold parameters and the upper and lower solutions method. The impact of the domain evolution rate on the persistence or extinction of species is analyzed. Numerical simulations are performed to illustrate our analytical results.
An air-stable prelithiation technology for lithium ion-sulfurized polyacrylonitrile battery
Authors: Shuai Yi , Lou Jin , Wang Yu , Chen Kanghua
Published: August 2019

Lithium-sulfurized polyacrylonitrile battery is a promising candidate among lithium metal batteries. Nevertheless, the formation of Li dendrites is recognized the worst problem for battery. In this study, we demonstrate an air-stable prelithiation technology for highly reversible Li ion-S@PAN battery. A sandwich-like structure is designed for a lithium–silicon/graphite compound, which not only prevent attack of the lithium surface from humid air, but also improve the lithiation progress more convenient and reliable. When test in Li ion-sulfurized polyacrylonitrile battery, a specific capacity up to 560[Formula: see text]mAh[Formula: see text], and only 24% capacity loss is witnessed after 1500 cycles at 1000[Formula: see text]mA[Formula: see text].
Dielectric and frequency-dependent transport properties of lanthanum-doped bismuth ferrite
Authors: Sahu A. K. , Satpathy S. K. , Behera Banarji
Published: August 2019

Polycrystalline samples of Bi[Formula: see text]LaxFeO3 [[Formula: see text], 0.6, 0.7 and 0.8] were synthesized through high temperature solid state reaction method. The structural studies of the compounds were done using X-ray diffraction technique. Dielectric constant and dielectric loss were studied for various frequencies (100[Formula: see text]Hz–104[Formula: see text]Hz) at different temperatures. The temperature-dependent non-Debye type relaxation process was suggested in the materials from the analysis of frequency-dependent electrical data at different temperatures. Temperature dependence of dc and ac conductivity at various frequencies showed negative temperature coefficient of resistance (NTCR) behavior. The frequency dependence of ac conductivity at different temperatures obeyed Jonscher’s universal power law. The temperature dependence of dc and ac conductivity was fitted to Arrhenius equation. The activation energies at different temperature ranges were calculated to know the charge species involved in the conduction process.
CloseUp—A Community-Driven Live Online Search Engine
Authors: Der Weth Christian Von , Abdul Ashraf , Kashyap Abhinav R. , Kankanhalli Mohan S.
Published: August 2019

Search engines are still the most common way of finding information on the Web. However, they are largely unable to provide satisfactory answers to time- and location-specific queries. Such queries can best and often only be answered by humans that are currently on-site. Although online platforms for community question answering are very popular, very few exceptions consider the notion of users’ current physical locations. In this article, we present CloseUp, our prototype for the seamless integration of community-driven live search into a Google-like search experience. Our efforts focus on overcoming the defining differences between traditional Web search and community question answering, namely the formulation of search requests (keyword-based queries vs. well-formed questions) and the expected response times (milliseconds vs. minutes/hours). To this end, the system features a deep learning pipeline to analyze submitted queries and translate relevant queries into questions. Searching users can submit suggested questions to a community of mobile users. CloseUp provides a stand-alone mobile application for submitting, browsing, and replying to questions. Replies from mobile users are presented as live results in the search interface. Using a field study, we evaluated the feasibility and practicability of our approach.
Editor's introduction
Authors: Ross Derek G.
Published: August 2019

It is my sincere pleasure to author my first Editorial since joining
Communication Design Quarterly
as Editor in Chief in 2018. It is a real pleasure to work with the dedicated, inspiring group of people that form the Special Interest Group for Design of Communication, and a true honor to be trusted with the work of all who submit to
CDQ
's pages.
The Properties of the Solar Corona and Its Connection to the Solar Wind
Authors: Cranmer Steven R. , Winebarger Amy R.
Published: August 2019

The corona is a layer of hot plasma that surrounds the Sun, traces out its complex magnetic field, and ultimately expands into interplanetary space as the supersonic solar wind. Although much has been learned in recent decades from advances in observations, theory, and computer simulations, we still have not identified definitively the physical processes that heat the corona and accelerate the solar wind. In this review, we summarize these recent advances and speculate about what else is required to finally understand the fundamental physics of this complex system. Specifically: ▪ We discuss recent subarcsecond observations of the corona, some of which appear to provide evidence for tangled and braided magnetic fields and some of which do not. ▪ We review results from three-dimensional numerical simulations that, despite limitations in dynamic range, reliably contain sufficient heating to produce and maintain the corona. ▪ We provide a new tabulation of scaling relations for a number of proposed coronal heating theories that involve waves, turbulence, braiding, nanoflares, and helicity conservation. An understanding of these processes is important not only for improving our ability to forecast hazardous space-weather events but also for establishing a baseline of knowledge about a well-resolved star that is relevant to other astrophysical systems.
A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo
Authors: Pickett Melissa A. , Naturale Victor F. , Feldman Jessica L.
Published: August 2019

Polarization along an apico-basolateral axis is a hallmark of epithelial cells and is essential for their selective barrier and transporter functions, as well as for their ability to provide mechanical resiliency to organs. Loss of polarity along this axis perturbs development and is associated with a wide number of diseases. We describe three steps involved in polarization: symmetry breaking, polarity establishment, and polarity maintenance. While the proteins involved in these processes are highly conserved among epithelial tissues and species, the execution of these steps varies widely and is context dependent. We review both theoretical principles underlying these steps and recent work demonstrating how apico-basolateral polarity is established in vivo in different tissues, highlighting how developmental and physiological contexts play major roles in the execution of the epithelial polarity program.
Molecular mechanism of TMEM16A regulation: role of CaMKII and PP1/PP2A
Authors: Ayon Ramon J. , Hawn Matthew B. , Aoun Joydeep , Wiwchar Michael , Forrest Abigail S. , Cunningham Fiona , Singer Cherie A. , Valencik Maria L. , Greenwood Iain A. , Leblanc Normand
Published: August 2019

This study explored the mechanism by which Ca2+-activated Cl− channels (CaCCs) encoded by the Tmem16a gene are regulated by calmodulin-dependent protein kinase II (CaMKII) and protein phosphatases 1 (PP1) and 2A (PP2A). Ca2+-activated Cl− currents ( IClCa) were recorded from HEK-293 cells expressing mouse TMEM16A. IClCa were evoked using a pipette solution in which free Ca2+ concentration was clamped to 500 nM, in the presence (5 mM) or absence of ATP. With 5 mM ATP, IClCa decayed to <50% of the initial current magnitude within 10 min after seal rupture. IClCa rundown seen with ATP-containing pipette solution was greatly diminished by omitting ATP. IClCa recorded after 20 min of cell dialysis with 0 ATP were more than twofold larger than those recorded with 5 mM ATP. Intracellular application of autocamtide-2-related inhibitory peptide (5 µM) or KN-93 (10 µM), two specific CaMKII inhibitors, produced a similar attenuation of TMEM16A rundown. In contrast, internal application of okadaic acid (30 nM) or cantharidin (100 nM), two nonselective PP1 and PP2A blockers, promoted the rundown of TMEM16A in cells dialyzed with 0 ATP. Mutating serine 528 of TMEM16A to an alanine led to a similar inhibition of TMEM16A rundown to that exerted by either one of the two CaMKII inhibitors tested, which was not observed for three putative CaMKII consensus sites for phosphorylation (T273, T622, and S730). Our results suggest that TMEM16A-mediated CaCCs are regulated by CaMKII and PP1/PP2A. Our data also suggest that serine 528 of TMEM16A is an important contributor to the regulation of IClCa by CaMKII.
Acute inhibition of protein deacetylases does not impact skeletal muscle insulin action
Authors: Martins Vitor F. , Begur Maedha , Lakkaraju Shivani , Svensson Kristoffer , Park Ji , Hetrick Byron , McCurdy Carrie. E. , Schenk Simon
Published: August 2019

Whether the histone deacetylase (HDAC) and sirtuin families of protein deacetylases regulate insulin-stimulated glucose uptake, independent of their transcriptional effects, has not been studied. Our objective was to determine the nontranscriptional role of HDACs and sirtuins in regulation of skeletal muscle insulin action. Basal and insulin-stimulated glucose uptake and signaling and acetylation were assessed in L6 myotubes and skeletal muscle from C57BL/6J mice that were treated acutely (1 h) with HDAC (trichostatin A, panobinostat, TMP195) and sirtuin inhibitors (nicotinamide). Treatment of L6 myotubes with HDAC inhibitors or skeletal muscle with a combination of HDAC and sirtuin inhibitors increased tubulin and pan-protein acetylation, demonstrating effective impairment of HDAC and sirtuin deacetylase activities. Despite this, neither basal nor insulin-stimulated glucose uptake or insulin signaling was impacted. Acute reduction of the deacetylase activity of HDACs and/or sirtuins does not impact insulin action in skeletal muscle.
Impact of task-specific training on saccadic eye movement performance
Authors: Montenegro Stephanie M. , Edelman Jay A.
Published: August 2019

Prosaccades are saccadic eye movements made reflexively in response to the sudden appearance of visual stimuli, whereas antisaccades are saccades that are directed to a location opposite a stimulus. Bibi and Edelman (Bibi R, Edelman JA. J Neurophysiol 102: 3101–3110, 2009) demonstrated that decreases in reaction time resulting from training prosaccades along one spatial axis (horizontal or vertical) could transfer to prosaccades made along the other axis. To help determine whether visual or motor-related processes underlie this facilitation, in the present study we trained participants to make prosaccades and probed their performance (reaction time, error rate) on antisaccade trials and vice versa. Subjects were probed for the effects of training on saccade performance before, during, and after 12 sessions of training. Training on prosaccades improved performance on both pro- and antisaccade tasks. Antisaccade training, with either a classic step task or a gap task, improved performance on gap prosaccades, though by less than it improved antisaccade performance, but had limited effect on an overlap prosaccade task. Across all subjects, training on one task only rarely had an adverse impact on an untrained task. These findings suggest that the predominant effect of saccade training is to facilitate fixation disengagement and motor preparation processes while having little impact on visual input to the saccadic system.

NEW & NOTEWORTHY This is the first systematic examination of whether training of prosaccades and antisaccades is task specific or instead transfers to the other saccade type. It finds that training tends to improve performance of all saccade types tested. These behavioral results provide insight into saccade neurophysiology, suggesting that saccade training enhances processes related to motor excitation and inhibition.
High-definition tDCS to the right temporoparietal junction modulates slow-wave resting state power and coherence in healthy adults
Authors: Donaldson Peter H. , Kirkovski Melissa , Yang Joel S. , Bekkali Soukayna , Enticott Peter G.
Published: August 2019

The right temporoparietal junction (rTPJ) is a multisensory integration hub that is increasingly utilized as a target of stimulation studies exploring its rich functional network roles and potential clinical applications. While transcranial direct current stimulation (tDCS) is frequently employed in such studies, there is still relatively little known regarding its local and network neurophysiological effects, particularly at important nonmotor sites such as the rTPJ. The current study applied either anodal, cathodal, or sham high-definition tDCS to the rTPJ of 53 healthy participants and used offline EEG to assess the impacts of stimulation on resting state (eyes open and eyes closed) band power and coherence. Temporoparietal and central region delta power was increased after anodal stimulation (the latter trend only), whereas cathodal stimulation increased frontal region delta and theta power. Increased coherence between right and left temporoparietal regions was also observed after anodal stimulation. All significant effects occurred in the eyes open condition. These findings are discussed with reference to domain general and mechanistic theories of rTPJ function. Low-frequency oscillatory activity may exert long-range inhibitory network influences that enable switching between and integration of endogenous/exogenous processing streams.

NEW & NOTEWORTHY Through the novel use of high-definition transcranial direct current stimulation (tDCS) and EEG, we provide evidence that both anodal and cathodal stimulation of the right temporoparietal junction selectively modulate slow-wave power and coherence in distributed network regions of known relevance to proposed temporoparietal junction functionality. These results also provide direct evidence of the ability of tDCS to modulate oscillatory activity at a long-range network level, which may have explanatory power in terms of both neurophysiological and behavioral effects.
Investigating stimulation parameters for preferential small-fiber activation using exponentially rising electrical currents
Authors: Hugosdottir Rosa , Mørch Carsten Dahl , Andersen Ole Kæseler , Arendt-Nielsen Lars
Published: August 2019

Electrical stimulation is widely used in pain research and profiling, but current technologies lack selectivity toward small sensory fibers. Pin electrodes deliver high current density in upper skin layers, and it has been proposed that slowly rising exponential pulses can elevate large-fiber activation threshold and thereby increase preferential small-fiber activation. Optimal stimulation parameters for the combined pin electrode and exponential pulse stimulation have so far not been established, which is the aim of this study. Perception thresholds were compared between pin and patch electrodes using single 1- to 100-ms exponential and rectangular pulses. Stimulus-response functions were evaluated for both pulse shapes delivered as single pulses and pulse trains of 10 Hz using intensities from 0.1 to 20 times perception threshold. Perception thresholds (mA) decreased when duration was increased for both electrodes with rectangular pulses and the pin electrode with exponential pulses. For the patch electrode, perception thresholds for exponential pulses decreased for durations ≤10 ms but increased for durations ≥15 ms, indicating accommodation of large fibers. Stimulus-response curves for single pulses were similar for the two pulse shapes. For pulse trains, the slope of the curve was higher for rectangular pulses. Maximal large-fiber accommodation to exponential pulses was observed for 100-ms pulses, indicating that 100-ms exponential pulses should be applied for preferential small-fiber activation. Intensity of 10 times perception threshold was sufficient to cause maximal pain ratings. The developed methodology may open new opportunities for using electrical stimulation paradigms for small-fiber stimulation and diagnostics.

NEW & NOTEWORTHY Selective activation of small cutaneous nerve fibers is pivotal for investigations of the pain system. The present study demonstrated that patch electrode perception thresholds increase with increased duration of exponential currents from 20 to 100 ms. This is likely caused by large-fiber accommodation, which can be utilized to activate small fibers preferentially through small-diameter pin electrodes. This finding may be utilized in studies of fundamental pain mechanisms and, for example, in small-fiber neuropathy.
Optimization Analysis of Controlled Blasting for Passing through Houses at Close Range in Super‐Large Section Tunnels
Authors: Song Zhanping , Mao Jianchao , Tian Xiaoxu , Zhang Yuwei , Wang Junbao
Published: August 2019

According to the on‐site vibration velocity monitoring and peak vibration velocity prediction, it is found that the maximum vibration velocity generated by the existing Dizong blasting scheme does not meet the requirements of the maximum allowable vibration velocity of houses. Therefore, the existing blasting scheme is optimized by reducing the maximum single‐segment charge and a variety of damping measures such as multistage duplex wedge groove, adding damping hole, and millisecond blasting. In addition, the blasting data before and after optimization are analyzed and compared by wavelet (packet) technology. The results show that the optimized blasting main frequency domain is increased to 50∼150 Hz and the maximum vibration intensity value is reduced by 79.8%. Based on the time‐energy analysis, the maximum energy value is reduced by 67.75% compared with the original scheme, and the dominant energy of the original scheme is reduced by 97.81%, 71.49%, 82.44%, 95.93%, and 93.03%, respectively, after optimization. The maximum vibration velocity generated by the optimized blasting scheme construction is 1.12 cm/s, which is less than the maximum allowable vibration velocity of the building of 1.2 cm/s, which meets the maximum allowable vibration velocity requirements of the building. The optimized blasting scheme realizes the safe and rapid construction of the two steps of the Dizong tunnel, which can provide a reference for similar engineering construction in the future.
A Rare Case of Bronchial Anthracofibrosis with Pleural Anthracosis Presented as Recurrent Pleural Effusion
Authors: Yadav Rajesh Kumar , Saini Jitendra Kumar , Sethi Prabhpreet , Sarin Rohit
Published: August 2019

A fifty-eight-year-old, nonsmoker Indian male presented with recurrent left pleural effusion. He had history of dry cough, exertional breathlessness for the last two years. He denied any occupational exposure or second hand smoke exposure. His physical examination demonstrated decreased breath sounds on the left side of chest. Cardiac evaluation was unremarkable. Diagnostic pleural aspiration revealed straw coloured fluid, exudative, and nonmalignant in nature. CT-imaging of the chest demonstrated left pleural effusion, nodular parenchymal infiltrates in bilateral lungs, plate like atelectasis in the left lower lobe. Bronchoscopy showed diffuse airway pigmentation, right middle lobe opening, and left lower lobe bronchus pigmented and stenosed. Semi-rigid pleuro-videoscopy revealed diffuse black coloured deposits over visceral pleura and focally scattered deposits over parietal pleura. Spirometry showed mild airway obstruction with moderate impairment in diffusion capacity.
A Miniaturized Periodic Microstrip Leaky Wave Antenna with Shorting Pins
Authors: Xi Bin , Li Yuanxin , Long Yunliang
Published: August 2019

A miniaturized periodic microstrip leaky wave antenna (MLWA) with shorting pins is proposed in this paper. The suggested antenna consists of a number of stubs that are periodically placed on the side of the transmission line, with the outside edges of the stubs being all integrated with shorting pins. In comparison with the whole-width stubs MLWA, the proposed antenna has an advantage of effective reduction in antenna size for the similar beam-scanning capability. A series of simple and effective equations were obtained to calculate the propagation constant and determine the operating band of the antenna. The consistency of the calculated and measured propagation constant confirms the validity of the parameter equations. As demonstrated by experimental results, the main beam scans electronically and continuously from 145° to 61° in the y-z plane as the operating frequency changes from 5.7 GHz to 11.7 GHz.
Physicochemical and Antioxidant Properties of the Degradations of Polysaccharides from Dendrobium officinale and Their Suitable Molecular Weight Range on Inducing HeLa Cell Apoptosis
Authors: Zhang Xiaofeng , Luo Yingyi , Wei Gang , Li Yunrong , Huang Yuechun , Huang Jiahui , Liu Chenxing , Huang Runping , Liu Guoxiong , Wei Zhaofeng , Du Shuxiu
Published: August 2019

Different molecular weight polysaccharides of Dendrobium officinale (DOPs) have gradually attracted attention because of their broad biological activities. They, however, remain poorly defined whether their antitumor activity is associated with molecular weight. In this study, the physicochemical, antioxidant, and antitumor properties of DOPs, including the crude polysaccharide (DOP) and its six degradation fractions (DOP1–DOP6) extracted from Dendrobium officinale, were determined. Consequently, DOPs were mainly composed of different ratios of mannose and glucose as follows: 5.15 : 1, 4.62 : 1, 4.19 : 1, 4.46 : 1, 4.32 : 1, 4.29 : 1, and 4.23 : 1, and their molecular weights were significantly different ranging from 652.29 kDa to 11.10 kDa. With the concentration increase of DOPs, the scavenging capacity against OH and DPPH free radicals increased. The antitumor ability of DOPs was different that DOP1–DOP5 (Mw: 176.29 kDa–28.48 kDa) exhibited the best antiproliferation activity than DOP (Mw: 652.29 kDa) and DOP6 (Mw: 11.10 kDa) in HeLa cells rather than PC9, A549, and HepG2 cells. Moreover, it is worth mentioning that DOP1 and DOP5 showed stronger capability on inducing apoptosis of HeLa cells than DOP and DOP6 via the mitochondrial pathway by upregulating the ratio of the Bax/Bal-2 mRNA expression. The results demonstrated that DOPs can be used as the potential natural antioxidant and antitumor products in pharmaceutical industries, and the molecular weight is a crucial influential factor of their antitumor activity that 28.48 kDa–176.29 kDa is a suitable range we may refer to.
Seismic Bearing Capacity of Strip Footings on Cohesive Soil Slopes by Using Adaptive Finite Element Limit Analysis
Authors: Luo Weihua , Zhao Minghua , Xiao Yao , Zhang Rui , Peng Wenzhe
Published: August 2019

By employing adaptive finite element limit analysis (AFELA), the seismic bearing capacity of strip footing on cohesive soil slopes are investigated. To consider the earthquake effects, the pseudostatic method is used. The upper and lower bounds for the seismic bearing capacity factor (Nce) are calculated, and the relative errors between them are found within 3% or better by adopting the adaptive mesh strategy. Based on the obtained results, design tables and charts are provided to facilitate engineers use, and the effects of footing position, undrained shear strength, slope angle, slope height, and pseudostatic acceleration coefficient are studied in detail. The collapse mechanisms are also discussed, including overall slope failure and foundation failure.
Mandibular Full-Arch Rehabilitation over 3 Straight Immediately Loaded Implants: 8 Years of Follow-Up
Authors: Formiga Márcio de Carvalho , Nagasawa Magda , Shibli Jamil Awad
Published: August 2019

Mandibular full-arch restoration is a good and successful treatment option for totally edentulous patients. In the past years, several studies have described the placement of 4 to 6 implants to restore this type of case; however, an option using 3 dental implants placed in strategic and specific positions could also be an alternative. Therefore, this case report describes a full-arch rehabilitation on 3 straight, immediately loaded implants after 8 years of follow-up. The restoration presented no biological or technical complications during this follow-up period, showing that an adequate treatment plan was able to allow good results using this treatment option.
Phytochemical Constituents, Antioxidant, Cytotoxicity, Antimicrobial, Antitrypanosomal, and Antimalarial Potentials of the Crude Extracts of Callistemon citrinus
Authors: Larayetan Rotimi , Ololade Zacchaeus S. , Ogunmola Oluranti O. , Ladokun Ayodele
Published: August 2019

Plants are reservoir for potentially useful bioactive compounds, and owing to the rising occurrences of drug resistance to malaria parasites, there is a need to discover and develop new phytochemicals in plant that can be used as antimalarial agents. In this study, we gave a detailed description of the phytochemicals present in both ethyl acetate and methanolic extracts of Callistemon citrinus (C. citrinus) using Gas Chromatography-Mass Spectrometry (GC-MS) analysis; both extracts were also evaluated for their in vitro antimalarial, antitrypanosomal, and cytotoxicity activities against Trypanosoma brucei brucei (T. b brucei) parasites, Plasmodium falciparum (P. falciparum) malaria parasites 3D7 strain, and human cervix adenocarcinoma cells (HeLa cells); in addition, the antimicrobial and antioxidant efficacies were determined using standard methods. Both extracts were characterized by a high amount of fatty acids (52.88 and 62.48%). The ethyl acetate extract exhibited a greater activity with minimum inhibitory concentration (MIC) values ranging from 0.025 to 0.10 mg/mL while the methanol extract ranged from 0.025 to 0.15 mg/mL. Both extracts were bactericidal to Escherichia coli ATCC 35150 (E. coli) and Pseudomonas aeruginosa ACC (P. aeruginosa). Qualitative and quantitative phytochemical screenings conducted for both extracts revealed the presence of alkaloids, glycosides, saponins, steroids, and triterpenoids, fat and oils, flavonoids, phenols, and tannins in varying amounts. Both crude extracts exhibited antitrypanosomal potentials with an IC50 of 6.6/9.7 μg/mL and antiplasmodial activities with an IC50 of 8.4/13.0 μg/mL. Conclusion from this study indicates that apart from the folkloric uses of this plant in traditional settings, the extracts possess a broad spectrum of antimicrobial, antitrypanosomal, and antimalarial activities and some pharmaceutically essential bioactive components with remarkable antioxidant capacities that may be used in the synthesis of novel drugs for the management of different varieties of ailments.
Simultaneous Laparoscopic Surgery for Bladder Diverticulum and Urachal Remnant: A Case Report
Authors: Murata Masaki , Inui Kohei , Hasegawa Moto , Ikeda Yohei , Nakagawa Yuki , Hara Noboru , Nishiyama Tsutomu
Published: August 2019

A 44-year-old woman visited a hospital with microscopic hematuria in June 2009. Computed tomography showed a large bladder diverticulum at right lateral wall and urachal remnant. Cystoscopic examination showed a large diverticulum at the right lateral wall that closes to the dome. She was followed up closely without therapeutic intervention; however, the residual urine increased gradually and frequent bladder diverticulitis developed. She underwent laparoscopic bladder diverticulectomy and excision of the urachal remnant simultaneously without any complications in August 2017. Laparoscopic approach for a large bladder diverticulum and urachal remnant is useful with safe, effective, and minimally invasive.
An Interesting Unknown Combined Pathology in a Patient with Acute Balance Problem
Authors: Yetiser Sertac , Karaman Kutlay
Published: August 2019

A 54-year-old woman with acute-onset nausea and vomiting presented to outpatient clinic. She had headache for 3 weeks. She had difficulty during tandem gait and was falling to the right. Otherwise, her neurological examination was normal. She had normal hearing. VNG analysis revealed spontaneous nystagmus beating to the left with optical fixation. However, she had horizontal and slightly down-beating gaze-evoked nystagmus at primary gaze position. Temporal bone CT and MRI showed widespread encephalitis of the right side of the brain and isolated destruction of the right superior semicircular canal. The patient was treated with high-dose combined antibiotics. She had remarkable recovery within 3 weeks.
Stiffness Calculation Method and Stiffness Characteristic Analysis of Bolted Connectors
Authors: Lu Shi-kun , Hua Deng-xin , Li Yan , Cui Fang-yuan , Li Peng-yang
Published: August 2019

At present, few scholars have studied the effect of surface roughness on assembly stiffness. The influence of the joint surface stiffness on the overall stiffness is neglected. In this paper, a new method for calculating the stiffness of bolted joints is presented. The effect of joint surface stiffness on the overall stiffness is considered. Firstly, the relationship between load and displacement between cylinder and cylinder (including the joint surface with certain roughness) is studied, and the stiffness characteristic expression of the joint surface is obtained; the results are compared with the traditional stiffness calculation theory, and then, the influence of bolt connection surface on bolt connection is studied and compared with the stiffness calculation results of traditional bolt connection. The results show that the theoretical model presented in this paper is more practical.
Analytical Solution for Finding the Second Zero of the Ahlfors Map for an Annulus Region
Authors: Wahid Nur H. A. A. , Murid Ali H. M. , Muminov Mukhiddin I.
Published: August 2019

The Ahlfors map is a conformal mapping function that maps a multiply connected region onto a unit disk. It can be written in terms of the Szegö kernel and the Garabedian kernel. In general, a zero of the Ahlfors map can be freely prescribed in a multiply connected region. The remaining zeros are the zeros of the Szegö kernel. For an annulus region, it is known that the second zero of the Ahlfors map can be computed analytically based on the series representation of the Szegö kernel. This paper presents another analytical method for finding the second zero of the Ahlfors map for an annulus region without using the series approach but using a boundary integral equation and knowledge of intersection points.
Experimental and Numerical Study on the Capability Behavior of a Thick‐Walled Spatial Cast‐Steel Joint under Complex Load Conditions
Authors: Zhang Binghan , Yang Bin , Wu Tiankai , Zhu Dayu , Lei Ke
Published: August 2019

A cast‐steel joint is always used as an important component for the safety of the whole structure at key points, and the capability of the joint is important for the cast‐steel joint. This paper conducts an experimental and numerical study on a 1/2 scale model of a joint in a real project. The experiment is used to validate the numerical model and then make further studies on the behavior of the joint by using a numerical method. Combining the result of the scale model test and numerical analysis shows that the joint can bear the prescribed load and it is still in the elastic stage. This paper also discusses the influence of the absence of the secondary moment, torque, and shear force. For the core area of the joint, the secondary moment and torque have little effect on the stress distribution, and the axial force of the secondary branches can increase the capability of the joint. But the secondary shear forces do have some effect on the stress of core area, and an enhancement coefficient is used to enlarge the axial force and moment to cover the absence of shear in the test.
Acquired Hemophilia A (FVIII Deficiency) Associated with Papillary Thyroid Cancer: Treatment with Recombinant Porcine FVIII
Authors: Nguyen S. , Teh P. , Zhou J. , Chang E. Y. , von Drygalski A.
Published: August 2019

Acquired hemophilia A (AHA) is a rare autoimmune disorder caused by autoantibodies against Factor VIII (FVIII). It has a high mortality due to bleeding complications. FVIIa-based bypassing agents are the first line of treatment but not always effective. Recombinant porcine (rp) FVIII (Obizur®) was recently approved for rescue treatment but with little evidence-based information regarding efficacy. We report a case of papillary thyroid cancer associated with AHA malignancy that responded to a single dose of rpFVIII after failure to achieve hemostasis with FVIIa-based bypassing products.
Modal Participation Estimated from the Response Correlation Matrix
Authors: Brincker Rune , Amador Sandro D. R. , Juul Martin , Lopez-Aenelle Manuel
Published: August 2019

In this paper, we are considering the case of estimating the modal participation vectors from the operating response of a structure. Normally, this is done using a fitting technique either in the time domain using the correlation function matrix or in the frequency domain using the spectral density matrix. In this paper, a more simple approach is proposed based on estimating the modal participation from the correlation matrix of the operating responses. For the case of general damping, it is shown how the response correlation matrix is formed by the mode shape matrix and two transformation matrices T1 and T1 that contain information about the modal parameters, the generalized modal masses, and the input load spectral density matrix Gx. For the case of real mode shapes, it is shown how the response correlation matrix can be given a simple analytical form where the corresponding real modal participation vectors can be obtained in a simple way. Finally, it is shown how the real version of the modal participation vectors can be used to synthesize empirical spectral density functions.
Addressing Challenges in Converting Grant-Funded Infrastructures to Broadly Used Research Resources
Authors: Rolland Betsy , Geiger Ann M.
Published: August 2019

The NCI invests heavily in research resources to serve the research community, including datasets, biospecimen banks, and networks of institutions in which clinical trials and other human subjects research are conducted. These resources often begin as grant-funded infrastructure initiated by scientists based on their own scientific interests, with a subsequent recognition of additional scientific uses. Although converting existing project-specific research activities into research resources may appear efficient in terms of time and financial investment, challenges can arise that undermine this efficiency and jeopardize future use. Here, we describe three challenges in the conversion process: (i) project-based infrastructure versus a research resource for a broader research community; (ii) complexity versus ease of use; and (iii) individual professional goals versus research resource priorities. We use our experience with the NCI-funded Cancer Research Network, particularly the Virtual Data Warehouse, to illustrate each challenge, concluding with strategies to mitigate each one. As studies grow in size and complexity, an ever-increasing volume of data, biospecimens, and human subjects research networks will be available for conversion to resources for scientific questions beyond those originally proposed. Addressing likely challenges thoughtfully can result in a more efficient conversion process and ultimately greater scientific impact.
Inhibition of NR4A1 Promotes ROS Accumulation and IL24-Dependent Growth Arrest in Rhabdomyosarcoma
Authors: Hedrick Erik , Mohankumar Kumaravel , Lacey Alexandra , Safe Stephen
Published: August 2019

Nuclear receptor 4A1 (NR4A1, Nur77) is overexpressed in rhabdomyosarcoma (RMS), and inactivation of NR4A1 (siNR4A1) or treatment with the NR4A1 antagonist 1,1-bis(3′-indoly)-1-(p-hydroxy-phenyl)methane (DIM-C-pPhOH) has antiproliferative and proapoptotic effects on RMS cells. However, the mechanism by which NR4A1 inhibition exerts these effects is poorly defined. Here, we report that NR4A1 silencing or inhibition resulted in accumulation of reactive oxygen species (ROS) and ROS-dependent induction of the tumor suppressor–like cytokine IL24 in RMS cells. Mechanistically, NR4A1 was found to regulate the expression of the proreductant genes thioredoxin domain-containing 5 (TXNDC5) and isocitrate dehydrogenase 1 (IDH1), which are downregulated in RMS cells following NR4A1 knockdown or inhibition. Silencing TXNDC5 and IDH1 also induced ROS accumulation and IL24 expression in RMS cells, suggesting that NR4A1 antagonists mediate their antiproliferative and apoptotic effects through modulation of proreductant gene expression. Finally, cotreatment with the antioxidant glutathione or IL24-blocking antibody reversed the effects of NR4A1 inhibition, demonstrating the importance of both ROS and IL24 in mediating the cellular responses.

Implications:

Overall, these data elucidate the mechanism by which NR4A1 inhibition functions to inhibit the proliferation, survival, and migration of RMS cells.
Prediction of the RNA Secondary Structure Using a Multi-Population Assisted Quantum Genetic Algorithm
Authors: Shi Sha , Zhang Xin-Li , Zhao Xian-Li , Yang Le , Du Wei , Wang Yun-Jiang
Published: August 2019

Quantum-inspired genetic algorithms (QGAs) were recently introduced for the prediction of RNA secondary structures, and they showed some superiority over the existing popular strategies. In this paper, for RNA secondary structure prediction, we introduce a new QGA named multi-population assisted quantum genetic algorithm (MAQGA). In contrast to the existing QGAs, our strategy involves multi-populations which evolve together in a cooperative way in each iteration, and the genetic exchange between various populations is performed by an operator transfer operation. The numerical results show that the performances of existing genetic algorithms (evolutionary algorithms [EAs]), including traditional EAs and QGAs, can be significantly improved by using our approach. Moreover, for RNA sequences with middle-short length, the MAQGA improves even this state-of-the-art software in terms of both prediction accuracy and sensitivity.
Prospects of Pluralism in Indonesia Gauged from a Legal Anthropological Perspective
Authors: Ramstedt Martin
Published: August 2019

The essentialist critique of liberal multiculturalism highlights the fact that the latter is inadvertently wedded to a collective cultural identity politics, which has encouraged the reification and rigidification of group identities. Foregrounding difference and preservationist attitudes, such identity politics tend to neglect the development of bridging social capital, and to undermine the emancipatory potential of liberal multicultural societies. In this article, I first seek to substantiate how pluralism in post-Suharto Indonesia has been articulated as liberal multiculturalism through increasing legal accommodation of certain ethnic, as well as conservative Muslim norms and institutions. Analysing how ethnic and religious identities have become more and more rigidly defined in the process, I then gauge the prospects of pluralism in the light of Rainer Forst’s four conceptions of tolerance.
Towards a Cosmopolitan Indonesia
Authors: Antweiler Christoph
Published: August 2019

Historically, Indonesia had a colonial experience of pluralist polities where cultures were divided but met in the marketplace. What we find less often in Indonesian history are truly pluralistic polities, that is polities either explicitly valuing diversity or emphasising trans-ethnic commonalities. In current Indonesia, behind cultural diversity issues as such, the more fundamental political issue looms large of how to organise multifaceted cultural diversity socially. I will argue that the answer lies not in playing diversity against unity, nor in emphasising secularism. Rather, my argument is based on cosmopolitan theories and the transdifference approach to cultural plurality and, thus, takes a stand against a mere focus on national and ethnic issues. In order to contribute to discussions about an explicitly diversity-honouring version of Indonesianess in everyday interactions, we can learn from revisiting historical experiences. Indonesia has a deep tradition of fruitful cultural exchanges and un-dogmatic religious syncretism. This is especially developed in Indonesia’s multicultural harbour cities. Based on my experience in Makassar (South Sulawesi) over a period of 30 years, this article provides a glance on a politically marginal but culturally cosmopolitan city, which has also been a centre of Islam since the 17th Century. Its specific form of localised cosmopolitanism might open some avenues for conceiving a pluralistic unity in Indonesia.
Conservative Inclusivity and Hierarchical Diversity
Authors: Hew Wai Weng
Published: August 2019

By discussing Chinese Muslim dakwah (proselytisation) activities, as well as examining how Chinese Muslims engage with broader Islamic practices, gain support from various Muslim organisations and interact with various Muslim individuals, this paper examines the possibilities, limitations, and challenges of religious pluralism in Indonesia today. Generally speaking, Chinese Muslims’ dakwah activities reflect the broader trend of religious discourses among Indonesian Muslims—a support for inclusivity and diversity, yet at the same time, an increasing “conservative turn;” and the notion of diversity has been redefined according to a rigid interpretation of Islamic teachings. I propose to understand such dynamics as forms of conservative inclusivity and hierarchical diversity. The challenge of religious pluralism in Indonesia today is less about the rejection of diversity among conservative Muslims, but more about the appropriation of the meaning of diversity and the scale of inclusivity.
Different German Perspectives on Spanish Politics in the 1670s: The Reaction of Vienna and Berlin on the Coup of Juan José de Austria in the Year 1677
Authors: Stolička Ondřej
Published: August 2019

The past thirty years has brought an important change into the scholarship of the period of the last Habsburgs on the Spanish throne. Named after the book by Christopher Storrs, the long-term paradigm of the decline of the Spanish monarchy in the last half of the seventeenth century has been reestablished, however, the research of the relationships between the Spanish Habsburgs and Central Europe in the last quarter of the seventeenth century has yet to be to be considered. This study presents a more complex perception of the coup led by Juan José of Austria in the year 1677 and discovers an important perception of the situation from the point of view of the Emperor Leopold I and the Elector of Brandenburg Frederick William. The new Spanish government, as well, enacted shifts in their politics which could endanger their positions, however both accepted the new situation differently.
English News in Papal Rome: Cross-Confessional Information Exchange in Reformation Europe
Authors: Keenan Charles R.
Published: August 2019

This essay argues that confessional differences had a direct impact on the circulation of news in early modern Europe. By examining how the Roman curia struggled to gather information about England during the reign of Queen Elizabeth I, it demonstrates how the Reformation both shaped and limited the information-gathering channels available to the papacy. The article begins by examining the various means by which the curia sought to collect news about English affairs, including via apostolic nuncios, Jesuits, and lay intelligencers, although fears of misinformation and imposters were always present. It then investigates the death of Elizabeth in 1603 as a case study to explore how quickly, and by what means, the Roman curia was able to verify news of a major event in a Protestant land.
International Criminal ‘Lawfare’ and its Potential Effects on Post-Conflict Positive Peace
Authors: Fisher Kirsten J.
Published: August 2019

This article examines how ‘international criminal lawfare’ (ICLf) has the potential to be a tool either to usher in a foundation of trust necessary to establish positive peace or to negatively affect post-conflict justice enterprises. It argues that problems that arise from ICLf through self-referrals to the icc can be alleviated if the Court would not need to rely on the cooperation and goodwill of parties to the conflict to pursue its investigations. Using the case study of the icc’s Uganda intervention, it contends that, despite its potential, the use of ICLf will not likely signal anything positive in situations where the judicial organ relies on a party to the conflict because the integrity of the process is undermined. This message is important in light of the icc Pre-Trial Chamber’s rejection of the Prosecutor’s request to investigate alleged crimes committed in Afghanistan on the basis of a lack of cooperation.
Orthodox Missions to the “Ancient Orthodox” Lands in Belarus and the 1839 Uniate Conversion
Authors: Skinner Barbara
Published: August 2019

A little known issue in the history of the conversion of Belarusian Uniates to Orthodoxy, formally completed in 1839, was the conflict between Russian Orthodox bishops who preferred to conduct missions among the Uniate population in Belarus to win personal conversions, incrementally, and the Uniate hierarchy who preferred the vossoedinenie, or general “reunification” en masse of the Uniate parishes. In the end, the Uniate strategy won the support of imperial officials and of Tsar Nicholas I himself, while the Orthodox eparchial representatives were compelled to cease their efforts in order not to impede the greater goal of general vossoedinenie. This issue sheds light on Orthodox priorities and imperial Russian prerogatives for the religious status of the lands of “western Russia,” and it also reveals the strength of the Orthodox and Uniate episcopal personalities involved.
Pilgrims and Profits
Authors: Frary Lucien
Published: August 2019

The Russian Company of Steam Navigation and Trade (Русское общество пароходства и торговли, or ROPiT) during the second half of the nineteenth century was more closely connected with national politics than any other merchant marine in the world. Politically, ROPiT enabled the Russian state to penetrate the tangled web of rivalry and prejudice that epitomized this era of European imperialism. Commercially, ROPiT improved the empire’s international trade and communications, while providing a foundation for the training of sailors. ROPiT also performed crucial postal services and yielded a useful fleet of transport vessels for public and private use. Based on company records and passengers’ reports, this paper focuses on the functioning of ROPiT as an aspect of the upsurge of pilgrimages to the sacred places of the Orthodox East during the late imperial period. It argues that ROPiT helped assert Russian influence and generate a sense of community within the Orthodox realm, from the Neva to the Nile.
Sandoval-Ortega, M.H., Siqueiros-Delgado, M.E., Pérez-Molphe-Balch, E. & Cerros-Tlatilpa, R. (2019) The holotype of Atheropogon stolonifer (=Bouteloua reederorum) and lectotypification of the name Triathera juncea (=B. juncea) (Poaceae, Chloridoideae). Phytotaxa 415 (1): 79–84.

Authors: SANDOVAL-ORTEGA MANUEL HIGINIO , SIQUEIROS-DELGADO MARÍA ELENA , PÉREZ-MOLPHE-BALCH EUGENIO , CERROS-TLATILPA ROSA
Published: August 2019

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