bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic accuracy and microbial profiles of tuberculous pleurisy: a comparative study of metagenomic next generation sequencing and GeneXpert Mycobacterium tuberculosis
Authors: Huang Fengxiang , Wang Haoran , Qiao Ruiping , Peng Qiang , Zhao Chang , Miao Lijun
Published: November 2023

Introduction

There is a clinical challenge in diagnosing tuberculous pleurisy accurately and promptly, highlighting the urgent need for a rapid and sensitive diagnostic method. This study aimed to evaluate the diagnostic accuracy of metagenomic next-generation sequencing (mNGS) and GeneXpert Mycobacterium tuberculosis (MTB) for identifying tuberculous pleurisy and analyzing the microbial profiles of both tuberculous and non-tuberculous pleural effusions.

Methods

The study enrolled 31 patients with suspected tuberculous pleurisy, of which 15 were confirmed to have tuberculous pleurisy and subsequently allocated to the tuberculous pleurisy group (TP group), while the remaining 16 individuals were assigned to the non-tuberculous pleurisy group (NTP group). mNGS and GeneXpert MTB were performed on pleural effusion samples, and the diagnostic accuracy of both tests was compared. We employed established formulas to compute crucial indicators, including sensitivity, specificity, missed diagnosis rate, misdiagnosed rate, positive predictive value (PPV), and negative predictive value (NPV).

Results

The results showed that both tests had high specificity (100%) and positive predictive value (100%) for detecting tuberculous pleurisy, along with comparable sensitivity (46.67% for mNGS and 40.0% for GeneXpert MTB). Further analysis of the combined efficacy of mNGS and GeneXpert MTB showed that the combined test had a sensitivity of 66.67% and a specificity of 100%. mNGS analysis revealed that MTB was detected in 7 out of 15 patients with tuberculous pleural effusions, while non-tuberculous pleural effusions were associated with a diverse range of microbial genera and species. The most frequently detected genera at the microbial genus level in the NTP group were Microbacterium spp. (6/16), Prevotella spp. (5/16), and Campylobacter spp. (5/16).

Discussion

These findings suggest that mNGS and GeneXpert MTB are useful diagnostic tools for identifying patients with tuberculous pleurisy, and mNGS can provide valuable insights into the microbial profiles of both tuberculous and non-tuberculous pleural effusions.
The effect of instrumental and vocal musical experience on tone categorical perception in individuals in a Chinese dialect area
Authors: Hao Jiayi , Zhong Yuhuan , Li Hong , Li Jianbo , Zheng Maoping
Published: November 2023

Introduction

Previous studies have shown that music training modulates adults’ categorical perception of Mandarin tones. However, the effect of music training on tone categorical perception ability in individuals in Chinese dialect areas remains unclear.

Methods

We recruited three groups of college students majoring in music in Chongqing, a dialect area in southwestern China. These groups included an instrumental music group (n = 31), a vocal music group (n = 32), and an instrumental-vocalist music group (n = 30). Additionally, we recruited a group of college students who did not receive any music training (n = 32). The accuracy and reaction time of the four groups were measured using the oddball task and compared to explore the differences in their tone categorical perception ability.

Results

Considering both between-tone category and within-tone category, the three music groups showed both greater accuracy and shorter reaction times than the non-music group. Regarding the three music groups, no significant differences in accuracy and reaction time were detected between the instrumental and vocal groups. However, the instrumental vocalist group outperformed both the instrumental and vocal groups in terms of accuracy and reaction time.

Discussion

Results showed that music training seems to have a positive effect on the categorical perception of Mandarin tone categories in Chinese dialect areas, and demonstrated that the combination of instrumental and vocal music training can further enhance tone categorical perception. To some extent, these findings provide a theoretical basis for the improvement of individual tone perception ability in dialect areas, and provided theoretical support for music and language education.
Using the Theory of Practice Architectures to establish what it means to “do” learning design, and the arrangements that enable and constrain practice
Authors: Olney Tom , Wood Carlton
Published: November 2023

In the past decade, learning design has become a widely adopted field of practice for higher education institutions (HEI) engaged with producing online and distance learning materials. To date, much has been written about the conceptual principles of guidance, representation, and sharing that underpin learning design, and the theoretical frameworks, models, tools, and instruments that have also been developed to support it. However, little analysis has been done to describe learning design in the specific sites of practice into which it has been introduced, or to describe the arrangements that might enable or constrain the embedding of this digital learning innovation by the people tasked with doing so. This original research article utilizes the Theory of Practice Architectures (TPA) as a theoretical approach to establish what learning design practice is composed of, and how that practice is shaped by its multiple sites of practice in the STEM faculty of a large open and distance learning HEI. The analysis draws on evidence—captured longitudinally over 4 years—from surveys (n = 43), learning design analytics (n = 20), in-depth interviews with key stakeholders (n = 14), document analysis, and learning design workshop data (n = 28) about the journey of 28 modules from conceptualization to faculty approval for full module production. The application of TPA to this extensive data set offers new and under discussed identification of key challenges experienced in the adoption of learning design approaches. In the sites of practice explored here, two specific arrangements are discussed: time, and the legacy of the Open University Learning Design Initiative (OULDI). Both can be seen to constrain and enable practice in different ways. This study will be relevant for scholars and researchers attempting to evaluate current learning design approaches or looking to explore more accurate ways of describing what it means to “do” learning design, both now and in the future.
Associations of bone mineral density with sex hormone-binding globulin (SHBG) and testosterone in middle-aged Saudi men: a cross-sectional study
Authors: Yakout Sobhy M. , Khattak Malak Nawaz Khan , Al-Daghri Nasser M. , Al-Masri Abeer A. , Elsaid Mohamed A.
Published: November 2023

Objective

The present cross-sectional study examined the association between circulating levels of sex hormone-binding globulin (SHBG) and testosterone with bone mineral density (BMD) in middle-aged Arab men.

Methods

Clinical data of 103 middle-aged Saudi men (mean age 60.7±7.2) were extracted from the Osteoporosis Registry of the Chair for Biomarkers of Chronic Diseases, King Saud University in Riyadh, Saudi Arabia. Participants were categorized according to the presence of osteopenia (T-score -1.0 to -2.5) (N=47) and controls (N=56). Data collected included demographics and anthropometrics as well as levels of sex hormone-binding globulin (SHBG), testosterone and follicle-stimulating hormone (FSH) which were measured using commercially available assays. Free androgen index (FAI) was calculated.

Results

Those with osteopenia had significantly lower levels of FAI (p<0.05), and higher levels of SHBG (p<0.004) and FSH (p<0.005). In the osteopenia group, SHBG was positively correlated with age (r=0.33, p<0.05), while it was inversely correlated with BMD spine (r = -0.39, p<0.05) and T-score femur (r= -0.35, p<0.05) in the same group. Furthermore, testosterone was inversely correlated with BMI in the osteopenia group (r= -0.33, p<0.05) while FAI was positively correlated with T-score femur (r = 0.36, p<0.05) as well as in all participants (r= 0.24, p<0.05). Among controls, FAI had an inverse correlation with FSH (r= -0.28, p<0.05) and over-all (r= -0.22, p<0.05).

Conclusion

In summary, the associations elicited suggest that circulating levels of SHBG and FAI may be against age-related bone loss in middle-aged men.
Association between body composition and the risk of mortality in the obese population in the United States
Authors: Lee Heeso , Chung Hye Soo , Kim Yoon Jung , Choi Min Kyu , Roh Yong Kyun , Yu Jae Myung , Oh Chang-Myung , Kim Joon , Moon Shinje
Published: November 2023

Background

Recent studies have presented the concept of the obesity paradox, suggesting that individuals with obesity have a lower risk of death than those without obesity. This paradox may arise because body mass index (BMI) alone is insufficient to understand body composition accurately. This study investigated the relationship between fat and muscle mass and the risk of mortality in individuals with overweight/obesity.

Methods

We used data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2006 and 2011 to 2018, which were linked to mortality information obtained from the National Death Index. Multiple Cox regression analyses were performed to estimate mortality risk. Subgroup analysis was conducted using propensity score-matched (PSM) data for age, sex, and race/ethnicity.

Results

This study included 16,555 participants who were overweight/obese (BMI≥25 kg/m2). An increase in appendicular skeletal muscle mass index was associated with a lower mortality risk (hazard ratio [HR]: 0.856; 95% confidence interval [CI]: 0.802–0.915). This finding was consistent with the subgroup analysis of the PSM data. Contrastingly, a high fat mass index was associated with an increased risk of mortality. Sarcopenic overweight/obesity was significantly associated with high mortality compared to obesity without sarcopenia (HR: 1.612, 95%CI: 1.328–1.957). This elevated risk was significant in both age- and sex-based subgroups. This finding was consistent with the subgroup analysis using PSM data.

Conclusion

In contrast to the obesity paradox, a simple increase in BMI does not protect against mortality. Instead, low body fat and high muscle mass reduce mortality risk.
Exploring the clinical utility of angioinvasion markers in papillary thyroid cancer: a literature review
Authors: Buczyńska Angelika , Kościuszko Maria , Krętowski Adam Jacek , Popławska-Kita Anna
Published: November 2023

Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and angioinvasion, the invasion of blood vessels by cancer cells, is a crucial pathological feature associated with disease progression and poor prognosis. Thus, a comprehensive search of scientific databases was conducted to identify relevant studies investigating angioinvasion markers in PTC. The selected studies were reviewed and analyzed to assess the clinical significance and potential utility of these markers in predicting angioinvasion and guiding treatment decisions. Numerous studies have investigated various markers associated with angioinvasion in PTC, including oxidative stress, vascular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs), and other angiogenic factors. The results indicate that increased expression of these markers is correlated with the presence and extent of angioinvasion in PTC. Moreover, some studies suggest that these markers can serve as prognostic indicators and guide therapeutic strategies, such as selecting patients for more aggressive treatment approaches or targeted therapies. The findings from the reviewed literature highlight the potential clinical utility of angioinvasion markers in PTC. The identification and validation of reliable markers can aid in assessing the risk of angioinvasion, predicting disease progression, and optimizing treatment decisions for patients with PTC. However, further research and validation on larger patient cohorts are necessary to establish the robustness and generalizability of these markers in clinical practice.
Body composition and testosterone in men: a Mendelian randomization study
Authors: Ikehata Yoshihiro , Hachiya Tsuyoshi , Kobayashi Takuro , Ide Hisamitsu , Horie Shigeo
Published: November 2023

Background

Testosterone is an essential sex hormone that plays a vital role in the overall health and development of males. It is well known that obesity decreases testosterone levels, but it is difficult to determine the causal relationship between body composition and testosterone.

Methods

To investigate potential causal associations between body composition and testosterone levels by a first time application of Mendelian randomization methods. Exposure variables in men included body composition (fat mass, fat-free mass, and body mass index). In addition to whole body fat and fat-free mass, we examined fat and fat-free mass for each body part (e.g., trunk, left arm, right arm, left leg and right leg) as exposures. Instrumental variables were defined using genome-wide association study data from the UK Biobank. Outcome variables in men included testosterone levels (total testosterone [TT], bioavailable testosterone [BT], and sex hormone-binding globulin [SHBG]). A one-sample Mendelian randomization analysis of inverse-variance weighted and weighted median was performed.

Results

The number of genetic instruments for the 13 exposure traits related to body composition ranged from 156 to 540. Genetically predicted whole body fat mass was negatively associated with TT (β=-0.24, P=5.2×10-33), BT (β=-0.18, P=5.8×10-20) and SHBG (β=-0.06, P=8.0×10-9). Genetically predicted whole body fat-free mass was negatively associated with BT (β=-0.04, P=2.1×10-4), but not with TT and SHBG, after multiple testing corrections. When comparing the causal effect on testosterone levels, there was a consistent trend that the effect of fat mass was more potent than that of fat-free mass. There were no differences between body parts.

Conclusion

These results show that reducing fat mass may increase testosterone levels.
Cancer stem cell–immune cell crosstalk in breast tumor microenvironment: a determinant of therapeutic facet
Authors: Guha Aishwarya , Goswami Kuntal Kanti , Sultana Jasmine , Ganguly Nilanjan , Choudhury Pritha Roy , Chakravarti Mohona , Bhuniya Avishek , Sarkar Anirban , Bera Saurav , Dhar Sukanya , Das Juhina , Das Tapasi , Baral Rathindranath , Bose Anamika , Banerjee Saptak
Published: November 2023

Breast cancer (BC) is globally one of the leading killers among women. Within a breast tumor, a minor population of transformed cells accountable for drug resistance, survival, and metastasis is known as breast cancer stem cells (BCSCs). Several experimental lines of evidence have indicated that BCSCs influence the functionality of immune cells. They evade immune surveillance by altering the characteristics of immune cells and modulate the tumor landscape to an immune-suppressive type. They are proficient in switching from a quiescent phase (slowly cycling) to an actively proliferating phenotype with a high degree of plasticity. This review confers the relevance and impact of crosstalk between immune cells and BCSCs as a fate determinant for BC prognosis. It also focuses on current strategies for targeting these aberrant BCSCs that could open avenues for the treatment of breast carcinoma.
Humoral antibody response following mRNA vaccines against SARS-CoV-2 in solid organ transplant recipients; a status after a fifth and bivalent vaccine dose
Authors: Christophorou Emma , Nilsson Anna Christine , Petersen Inge , Lindvig Susan O. , Davidsen Jesper R. , Abazi Rozeta , Poulsen Mikael K. , Pedersen Rune M. , Justesen Ulrik S. , Johansen Nicolai E. , Bistrup Claus , Madsen Lone W. , Johansen Isik S.
Published: November 2023

Background

In solid organ transplant (SOT) recipients, the humoral response following COVID-19 vaccination is reduced, as a result of their immunosuppressed treatment. In this study, we investigated antibody concentrations after booster vaccinations until the fifth dose, the latter by monovalent or bivalent BA1 or BA4/5 vaccines. In addition, we evaluated the efficacy of vaccination by recording breakthrough infections, hospitalizations, and deaths.

Method

This prospective cohort study included 438 SOT recipients (>18 years) vaccinated with mRNA vaccines against COVID-19 from January 2021 until March 2023. Blood samples were drawn before and after each vaccination and tested for SARS-CoV-2 spike RBD IgG antibodies with the lowest and highest cut-off at 7.1 and 5,680 BAU/mL, respectively. Vaccine information, breakthrough infections, and hospitalizations were collected from the medical records.

Results

Most participants received BNT162b2 and 61.4% received five vaccine doses. The response proportion in SOT recipients increased from 86.7% after the fourth dose to 93.0% following the fifth dose. Antibody concentration decreased with 142.7 BAU/mL between the third and fourth dose (median 132 days, Quartile 1: 123, Quartile 3: 148) and 234.3 BAU/mL between the fourth and fifth (median 250 days, Quartile 1: 241, Quartile 3: 262) dose among those without breakthrough infection (p=0.34). When comparing the Omicron BA.1 or Omicron BA.4/BA.5 adapted vaccines, no significant differences in antibody concentration were found, but 20.0% of SOT recipients receiving a monovalent fifth vaccine dose had a breakthrough infection compared to 4.0% and 7.9% among those who received BA.1 and BA.4/BA.5 adapted vaccines, respectively (p=0.04). Since January 2021, 240 (54.8%) participants had a breakthrough infection, and 22 were hospitalized, but no deaths were observed.

Conclusions

The fifth COVID-19 vaccine dose raised antibody response to 93.0% of the study population. Additional booster doses, as well as bivalent vaccines, led to higher levels of antibody concentration in SOT recipients. We found a lower incidence of breakthrough infections among SOT recipients after receiving a bivalent vaccine as a fifth dose compared to those receiving a monovalent dose. Antibody concentrations did not wane when the time between doses was prolonged from four to eight months.
Transarterial chemoembolization combined donafenib with/without PD-1 for unresectable HCC in a multicenter retrospective study
Authors: Li Hao , Wang Jiacheng , Zhang Guokun , Kuang Donglin , Li Yanliang , He Xiang , Xing Cheng , Wang Yong , Shi Ming , Han Xinwei , Ren Jianzhuang , Duan Xuhua
Published: November 2023

Background & aims

This multicenter retrospective study evaluated the efficacy and safety of transarterial chemoembolization (TACE) combined with donafenib and a programmed death-1 (PD-1) inhibitor (TACE+DP) and TACE combined with donafenib (TACE+D) for unresectable hepatocellular carcinoma (uHCC).

Methods

The clinical data of 388 patients with uHCC who received TACE+DP or TACE+D as first-line treatment at six Chinese academic centers from July 2021 to July 2022 were collected and analyzed retrospectively. Patients in the TACE+DP group received an intravenous administration of a PD-1 inhibitor every three weeks and oral donafenib (0.2 g) twice daily until intolerable toxicity or disease progression. Patients in the TACE+D group received the same dose of donafenib for 3–5 days after TACE. Overall survival (OS) and progression-free survival (PFS)were analyzed by Kaplan-Meier method and log-rank test. The tumor response was compared between the two groups according to modified RECIST criteria. Adverse events were also analyzed between the two groups

Results

The TACE+D group included 157 patients and the TACE+DP group included 166 patients. Patients in the TACE+DP group had a longer median OS (18.1 vs. 13.2 months, P<0.001) and longer median PFS (10.6 vs. 7.9 months, P<0.001) than those in the TACE+D group. Patients in the TACE+DP group achieved a greater objective response rate (ORR; 50.6% vs. 41.4%, P=0.019) and greater disease control rate (DCR) (89.2% vs. 82.8%, P=0.010) than those in the TACE+D group. No significant differences were found in the incidence or severity of adverse events between the TACE+DP and TACE+D groups (any grade: 92.9% vs. 94.6%, P=0.270; grade 3 or 4: 33.8% vs. 37.3%, P=0.253).

Conclusion

With favorable safety and tolerability, TACE combined with donafenib and PD-1 inhibitors significantly improved PFS, OS, and ORR compared to TACE combined with donafenib.
Fluorescent non transgenic schistosoma to decipher host-parasite phenotype compatibility
Authors: Duval David , Poteaux Pierre , Gourbal Benjamin , Rognon Anne , Augusto Ronaldo De Carvalho
Published: November 2023

Schistosomiasis is considered as a significant public health problem, imposing a deeper understanding of the intricate interplay between parasites and their hosts. Unfortunately, current invasive methodologies employed to study the compatibility and the parasite development impose limitations on exploring diverse strains under various environmental conditions, thereby impeding progress in the field. In this study, we demonstrate the usefulness for the trematode parasite Schistosma mansoni, leveranging a fluorescence-imaging-based approach that employs fluorescein 5-chloromethylfluorescein diacetate (CMFDA) and 5-chloromethylfluorescein diacetate (CMAC) as organism tracker for intramolluscan studies involving the host snail Biomphalaria glabrata. These probes represent key tools for qualitatively assessing snail infections with unmatched accuracy and precision. By monitoring the fluorescence of parasites within the snail vector, our method exposes an unprecedented glimpse into the host-parasite compatibility landscape. The simplicity and sensitivity of our approach render it an ideal choice for evolutionary studies, as it sheds light on the intricate mechanisms governing host-parasite interactions. Fluorescent probe-based methods play a pivotal role in characterizing factors influencing parasite development and phenotype of compatibility, paving the way for innovative, effective, and sustainable solutions to enhance our understanding host-parasite immunobiological interaction and compatibility.
Unseen and unheard: the invisibility of kelp forests in international environmental governance
Authors: Valckenaere Jurgen , Techera Erika , Filbee-Dexter Karen , Wernberg Thomas
Published: November 2023

Kelp forests are one of the most extensive coastal ecosystems in the world. They serve a myriad of ecological functions, support substantial biodiversity, and contribute to a multitude of services essential to our contemporary society. Unfortunately, they are in decline. International governance regimes and institutions play an important role in addressing threats to marine ecosystems and combatting declines. However, not all ecosystems receive the same level of global governance attention. There is a growing interest in coastal ecosystems, and an overall increase in conservation targets and restoration programmes on many international platforms. We demonstrate that kelp forests consistently receive the least global governance attention compared to other dominant marine habitats. To address the disconnect between kelp science and environmental governance, we make five recommendations for the future.
The challenge of assessing the state of exploitation of short-lived fishery resources with limited data: the blue shrimp (Penaeus stylirostris) fishery in the Gulf of California, Mexico
Authors: Arreguín-Sánchez Francisco , Pérez-Quiñónez Carlos Iván , Hernández-López Armando , Chávez-Herrera Darío
Published: November 2023

Assessing the state of exploitation of a resource is key to its management. In the fishery of the blue shrimp, Penaeus stylirostris, off the central-eastern coast of the Gulf of Baja California, this assessment process is critical for two reasons: the data is limited because only catch and effort data are available, and the dynamic biomass model is not applicable to short-lived (annual) species. In this study, a procedure based on the Leslie model was used, and applied to the last 15 annual fishing seasons (2006 to 2021). Estimates of the monthly biomass per fishing season, the corresponding harvest rates (HRy), and indicators for the survival ratio, sy, representing the remaining stock at the end of the fishing season (essentially spawners), and the fishery’s recruitment rate, ρy, at the beginning of the fishing season, were obtained. These last two quantities, sy and ρy, were related to identify a limit biological reference point that reflects the replacement level for the shrimp stock, defined here as the limit for population renewal rate, PRRLim. Initially, a Kobe diagram was constructed based on HRy and sy, which indicated a sustainable fishery status that requires management measures to limit fishing to keep it sustainable, which is currently being implemented. A Kobe diagram was also constructed based on ρy, instead of sy, yielding the same results. Additionally, we used Kobe’s diagrams to show the contribution of the environment and an ecosystem-based reference point.
The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial
Authors: Zheng Yuling , Huang Jinping , Mai Ying , Li Xiaoling , Zhang Zhongqi
Published: November 2023

Objective

Propofol-opioids are the most common drug combination and can reduce the dose of propofol and the incidence of adverse events in painless artificial abortion. We hypothesized that butorphanol may reduce the median effective dose (ED50) of propofol, propofol injection pain, and postoperative uterine contraction pain.

Methods

This was a randomized, double-blind, controlled study. A total of 54 female patients, who had ASA I or II, aged 18–49 years, undergoing painless artificial abortion, were randomly assigned into two groups, namely, Group P (propofol) and Group PB (propofol plus 10 μg/kg butorphanol). According to the pre-experiment, the initial dose of propofol for the P and PB groups was 3 and 2.5 mg/kg, respectively, with a dose gradient of 0.25 mg/kg. The ED50 of propofol was analyzed using probit regression analysis. The total propofol dose consumed, recovery time, and anesthesia-related adverse events were also recorded.

Results

There were 25 and 29 patients in the P and PB groups, respectively. The ED50 (95% CI) of propofol for artificial abortion were 2.477 (2.186–2.737) and 1.555 (1.173–1.846) mg/kg in the P and PB groups, respectively. The total propofol dose consumed was (150.7 ± 21.7) mg and (110.4 ± 28.2) mg in the P and PB groups, respectively (P < 0.001). Compared with the P group, injection-site pain (76 vs. 20.7%) and uterine contraction pain (72 vs. 6.9%) in the PB group had a significant decrease (P < 0.001).

Conclusion

Combination of propofol with 10 μg/kg butorphanol reduced the ED50 of propofol and decreased the incidence of propofol injection-site pain and postoperative uterine contraction pain during painless artificial abortion compared with propofol alone.

Clinical trial registration

https://www.chictr.org.cn/showproj.html?proj=166610, identifier: ChiCTR2200059795.
Social robots as effective language tutors for children: empirical evidence from neuroscience
Authors: Alimardani Maryam , Duret Jesse , Jouen Anne-Lise , Hiraki Kazuo
Published: November 2023

The aim of the current study was to investigate children's brain responses to robot-assisted language learning. EEG brain signals were collected from 41 Japanese children who learned French vocabularies in two groups; half of the children learned new words from a social robot that narrated a story in French using animations on a computer screen (Robot group) and the other half watched the same animated story on the screen but only with a voiceover narration and without the robot (Display group). To examine brain activation during the learning phase, we extracted EEG functional connectivity (FC) which is defined as the rhythmic synchronization of signals recorded from different brain areas. The results indicated significantly higher global synchronization of brain signals in the theta frequency band in the Robot group during the learning phase. Closer inspection of intra-hemispheric and inter-hemispheric connections revealed that children who learned a new language from the robot experienced a stronger theta-band EEG synchronization in inter-hemispheric connections, which has been previously associated with success in second language learning in the neuroscientific literature. Additionally, using a multiple linear regression analysis, it was found that theta-band FC and group assignment were significant predictors of children's language learning with the Robot group scoring higher in the post-interaction word recognition test. These findings provide novel neuroscientific evidence for the effectiveness of social robots as second language tutors for children.
Twenty-five-year mortality trends of four major histological subtypes of cervical cancer: a population-based study using the Osaka cancer registry data
Authors: Komura Naoko , Mabuchi Seiji , Sasano Tomoyuki , Kamiura Shoji , Morishima Toshitaka , Miyashiro Isao
Published: November 2023

Objective

To assess the mortality trends of four major histological subtypes of cervical cancer diagnosed between 1994 and 2018.

Methods

This population-based retrospective cohort study was conducted using the Osaka Cancer Registry data from 1994 to 2018. A total of 12,003 patients with cervical cancer, squamous cell carcinoma (SCC), adenocarcinoma (A), adenosquamous cell carcinoma (AS), or small cell neuroendocrine carcinoma (SCNEC) were identified. Patients were classified into groups according to the extent of disease (localized, regional, or distant), year of diagnosis (1994–2002, 2003–2010, or 2011–2018), and histological subtype (SCC, A/AS, or SCNEC). Then, their survival rates were assessed using univariate and multivariate analyses.

Results

Overall, improved survival rates were observed according to the year of diagnosis in patients with local, regional, and distant cervical cancers. When examined according to the histological subtypes, improved survival rates according to the year of diagnosis were observed in patients with local, regional, and distant SCCs and in those with local and regional A/AS. In patients with distant A/AS, the survival rates did not improve since 2003. In patients with cervical cancer with SCNEC, the survival rates did not improve since 1994 irrespective of the extent of the disease. In the multivariate analysis, non-SCC histology was found to be an independent prognostic factor for OS.

Conclusion

In contrast to SCC histology associated with improved survival between 1994 and 2018, SCNEC histology and advanced (stage IVB) A/AS remain to be the unmet medical needs for the management of cervical cancer.
Malignant transformation of desmoplastic infantile tumors in a non-infant: a case report
Authors: Yang Yan , Tian Bin , Chen Xuzhu , Liu Xin , Li Shiguang
Published: November 2023

Desmoplastic infantile tumors (DITs) are rare benign intracranial tumors in infants with benign biological behavior and rare malignant transformation characteristics. We present a DIT case that underwent malignant transformation and metastasis. A 6-year-old girl presented with DITs and underwent surgical resection. 12 years later, the tumor recurred and underwent surgical resection again. The pathology report confirmed the lesion to be a glioblastoma multiforme. She received adjuvant treatment. A year after the surgical operation of the lesions, she had intraspinal metastasis and underwent surgical resection again. Multiple spinal cord metastases were subsequently identified in the patient. The patient’s condition exhibited severe deterioration during the follow-up period. This case report focuses on the occurrence of DITs and their potential malignant transformation, as assessed through computed tomography and magnetic resonance imaging.
Analysis of the association between the acetabular morphology and femoral head in children aged 0–3 years with developmental hip dysplasia
Authors: Xu Liukun , Wang Bo , Wang Li , Zhang Zhiqun
Published: November 2023

Background

Magnetic resonance imaging (MRI) has been advocated as a routine examination for preoperative and postoperative assessment of Developmental Dysplasia of the Hip (DDH). However, there is limited research regarding the correlation between acetabulum and femoral head morphology using preoperative MRI measurements.

Objective

To explore the correlation between acetabulum and femoral head morphology in children with DDH aged 0–3 years, using MRI measurements as indicators.

Methods

A Retrospective Analysis of MRI Data from 172 Children Diagnosed with Developmental Dysplasia of the Hip (DDH) at Nanjing Medical University Affiliated Children's Hospital, spanning from January 2017 to January 2022. Measurements were taken to assess various parameters reflecting hip socket morphology as well as the development status of the femoral head and ossifying nucleus. The correlation between these factors was explored using Pearson correlation analysis and multiple-factor linear regression. Statistical analysis was conducted using SPSS 18.0 software.

Results

Pearson correlation analysis revealed statistically significant associations between the length of the ossifying nucleus ratio and age(mo.), BAI, BCAD, CTAD, and CTAD. The height of the ossifying nucleus ratio displayed statistically significant correlations with age(mo.) and BTAD. The length of the femoral head ratio exhibited statistically significant correlations with CAI, BCEA, and BCAD. Furthermore, the height of the femoral head ratio demonstrated a statistically significant correlation with BCEA. After adjusting for age(mo.), BMI, BCEA, and CCEA, BPoAcet and CPoAcet was found to be correlated with the length of the ossifying nucleus ratio. Preoperatively, the CAI, BAxAcet, BPoAcet, CPoAcet, and BTAD were correlated with the height of ossifying nucleus ratio after correcting for age, BMI, BCEA, and CCEA.

Conclusion

The measurement parameters of hip socket morphology on MRI are associated with femoral head development, making them potential predictive indicators for femoral head development in DDH patients. These findings offer valuable insights for clinical decisions regarding the timing and approach of surgery in patients with developmental hip dislocation.
Association between antihypertensive drugs and oral cancer: a drug target Mendelian randomization study
Authors: Guo Junfeng , Liu Rongxing , Sheng Fangfang , Wu Qiuxiang , Xu Rufu , He Haitao , Zhang Gang , Huang Junjie , Zhang Zhe , Zhang Rong
Published: November 2023

Background: Recent reports have suggested that antihypertensive drugs may play an oncogenic role in common cancers, but it is still uncertain whether this could influence the risk of oral cancer. Through two-sample Mendelian randomization (MR), we sought to assess the causal effect of antihypertensive drugs on oral cancer outcomes.

Methods: To proxy the exposure of antihypertensive drugs, we utilized two genetic instruments, including expression quantitative trait loci of drug target genes and genetic variants within or around drug target genes related to blood pressure from genome-wide association studies. Inverse-variance-weighted MR (IVW-MR) and summary-data-based MR (SMR) were employed to compute the instrument effect estimates.

Results: It was observed through IVW-MR analysis that there is a positive relationship between KCNH2 (target of beta-adrenoceptor blockers)–mediated blood pressure and oral cancer (odds ratio [OR] = 1.197, 95% confidence interval [CI] = 1.028–1.394). Similarly, SMR analysis demonstrated that a higher expression of KCNH2 (target of beta-adrenoceptor blockers) was linked to a greater risk of oral cancer (OR = 2.223, 95% CI = 1.094–4.516). Both analyses yielded no consistent evidence of other associations.

Conclusion: This two-sample MR study proposed a latent causal association between KCNH2 (target of beta-adrenoceptor blockers) inhibition and diminished risk of oral cancer.
Rethinking pain communication of patients with Alzheimer’s disease through E-textile interaction design
Authors: Li Yanheng , Bai Long , Mao Yaxuan , Ren Hongliang , Qiao Yu , Tong Xin , Lc Ray
Published: November 2023

Older individuals are easily prone to chronic pain. Due to the complexity of chronic pain, most elderly often have difficulty expressing pain to others to seek assistance, especially those with Alzheimer’s disease (AD). The caregivers cannot instantly discover the patients’ pain condition and provide timely pain management. This project applies physiological signal sensing technology to help AD patients express the presence of pain non-verbally. We embed sensors on patients’ handkerchiefs to identify the patient’s abnormal physical activity when pain occurs. Next, we translate the physiological signal into qualitative light alert to send to caregivers and indicate the pain occurrence condition. Then, utilizing multi-sensory stimulation intervention, we create an electronic textile (e-textile) tool to help caregivers effectively support patients in pain. And thus to create a two-way pain communication between caregivers and the patients. Pain perception can be independent of subjective expressions and tangibly perceived by others through our textile prototype. The e-textile handkerchiefs also bring up a new guide to facilitate communication for caregivers when their patients. We contribute the design insights of building a bio-sensing and e-textile system with considering the pain communication needs, patients’ pain behaviors and preference of objects. Our e-textile system may contribute to pain communication bio-sensing tool design for special elderly groups, especially those with weakened cognition and communication abilities. We provide a new approach to dealing with the pain of AD patients for healthcare professionals.
Robust oblique Target-rotation for small samples
Authors: Beauducel André , Hilger Norbert
Published: November 2023

Introduction

Oblique Target-rotation in the context of exploratory factor analysis is a relevant method for the investigation of the oblique simple structure. It was argued that minimizing single cross-loadings by means of target rotation may lead to large effects of sampling error on the target rotated factor solutions.

Method

In order to minimize effects of sampling error on results of Target-rotation we propose to compute the mean cross-loadings for each block of salient loadings of the independent clusters model and to perform Target-rotation for the block-wise mean cross-loadings. The resulting transformation-matrix is than applied to the complete unrotated loading matrix in order to produce mean Target-rotated factors.

Results

A simulation study based on correlated independent clusters model and zero-mean cross-loading models revealed that mean oblique Target-rotation resulted in smaller bias of factor inter-correlations than conventional Target-rotation based on single loadings, especially when sample size was small and when the number of factors was large. An empirical example revealed that the similarity of Target-rotated factors computed for small subsamples with Target-rotated factors of the total sample was more pronounced for mean Target-rotation than for conventional Target-rotation.

Discussion

Mean Target-rotation can be recommended in the context of oblique factor models based on simple structure, especially for small samples. An R-script and an SPSS-script for this form of Target-rotation are provided in the Supplementary Material.
Lesser relevance markers in Chinese academic spoken English corpus: a cross-disciplinary study on pragmatic features
Authors: Yu Yang , Zeng Gang
Published: November 2023

This study explores the usage characteristics and pragmatic functions of lesser relevance markers in academic spoken English lectures presented by Chinese scholars. A qualitative and quantitative approach is employed using the Chinese Academic Spoken English Corpus (CASEC), which encompasses disciplines in science, engineering, humanities, and social sciences. The findings reveal that Chinese scholars use lesser relevance markers less frequently compared to native English speakers. These differences in usage highlight the influence of language background, disciplinary culture, and communication conventions on the realization of informing evaluation, topic handling, and interactivity. Furthermore, within the Chinese scholars’ group, humanities and social sciences scholars tend to use lesser relevance markers more frequently than science and engineering scholars. This research enhances our understanding of the multifaceted pragmatic roles of lesser relevance markers and offers insights into cross-cultural academic communication and English teaching.
Social anxiety mediates workplace incivility and work engagement
Authors: Gan Samuel Ken-En , Zeng Yusong , Wang Zihan
Published: November 2023

The average working person spends between 35 and 60 h a week in the workplace, making it an influential place for mental well-being and a place for socioeconomic contribution. Workplace incivility can diminish positive mental health outcomes and negatively impact work engagement through increased social anxiety. To investigate this, 118 working adults in Singapore aged between 19 to 67 years old were recruited for a survey consisting of demographic questions, the Workplace Incivility Scale, the Brief DSM-5 Social Anxiety Disorder Severity Scale, and the Utrecht Work Engagement Scale-9 between November 2022 to April 2023. Correlational, regression, and mediation analysis showed workplace incivility scale scores to significantly predict social anxiety after controlling for covariates. This supports our hypothesis that employees exposed to workplace incivility would have higher social anxiety levels mediating work engagement after controlling for age and gender. The findings here show workplace incivility as a possible intervention target for social anxiety, in order to reduce negative impact on work engagement to improve employee experience and retention for organizations.
Helicobacter pylori infection prevalence declined among an urban health check-up population in Chengdu, China: a longitudinal analysis of multiple cross-sectional studies
Authors: Zou Jin-Chen , Wen Mao-Yao , Huang Yan , Chen Xin-Zu , Hu Jian-Kun ,   on behalf of the SIGES Research Group
Published: November 2023

Objectives

The efficacy of updated health policy in improving the generalization of Helicobacter pylori screening and eradication in southwest China was assessed in a longitudinal analysis of multiple cross-sectional studies from an institution.

Methods

In the periods 2009–2010, 2013–2014, and 2019–2021, 8,365, 16,914, and 18,281 urban observations from health check-ups at West China Hospital were analyzed, respectively. The 14C-urea or 13C-urea breath test was consistently used for H. pylori detection. The protocol has been reported elsewhere (PROSPERO Registration number: CRD42019120764).

Results

The overall prevalence of H. pylori dramatically decreased from 53.1% to 30.7% over the past decade (OR = 0.39, 95% CI 0.37–0.41), with a similar decline in all sex-specific and age-specific subgroups. The age-specific prevalence consistently increased before 40 years of age and always peaked at 50–59 years. Longitudinal clearance increased along with aging, and prevalence dropped to 22.6%, 25.1%, and 23.6% in the 40–49, 50–59, and 60–69 years initial age groups, respectively.

Conclusion

The generalization of H. pylori screening and eradication could greatly contribute to the control of H. pylori infection among urban health check-up populations and lower gastric cancer incidence.
Mapping the value for money of precision medicine: a systematic literature review and meta-analysis
Authors: Chen Wenjia , Wong Nigel Chong Boon , Wang Yi , Zemlyanska Yaroslava , Butani Dimple , Virabhak Suchin , Matchar David Bruce , Prapinvanich Thittaya , Teerawattananon Yot
Published: November 2023

Objective

This study aimed to quantify heterogeneity in the value for money of precision medicine (PM) by application types across contexts and conditions and to quantify sources of heterogeneity to areas of particular promises or concerns as the field of PM moves forward.

Methods

A systemic search was performed in Embase, Medline, EconLit, and CRD databases for studies published between 2011 and 2021 on cost-effectiveness analysis (CEA) of PM interventions. Based on a willingness-to-pay threshold of one-time GDP per capita of each study country, the net monetary benefit (NMB) of PM was pooled using random-effects meta-analyses. Sources of heterogeneity and study biases were examined using random-effects meta-regressions, jackknife sensitivity analysis, and the biases in economic studies checklist.

Results

Among the 275 unique CEAs of PM, publicly sponsored studies found neither genetic testing nor gene therapy cost-effective in general, which was contradictory to studies funded by commercial entities and early stage evaluations. Evidence of PM being cost-effective was concentrated in a genetic test for screening, diagnosis, or as companion diagnostics (pooled NMBs, $48,152, $8,869, $5,693, p < 0.001), in the form of multigene panel testing (pooled NMBs = $31,026, p < 0.001), which only applied to a few disease areas such as cancer and high-income countries. Incremental effectiveness was an essential value driver for varied genetic tests but not gene therapy.

Conclusion

Precision medicine’s value for money across application types and contexts was difficult to conclude from published studies, which might be subject to systematic bias. The conducting and reporting of CEA of PM should be locally based and standardized for meaningful comparisons.
Predictors of physical activity in older adults 65 years and older: findings in health survey of the Valencian Community
Authors: Trujillo-Barberá Silvia , García-Martínez Pedro , Sánchez-Martínez Juana María , Rodríguez-Herrera María Ángeles , Ruiz-Hontangas Antonio , Gámez-Paya Javier
Published: November 2023

Background

Physical activity is part of a healthy lifestyle in the older adult and is related to multiple variables that promote this behavior.

Objective

To identify the relationship and predictive power of sociodemographic variables, multimorbidity, severity index, risk of poor mental health, social support, affective support and confidential support with the time devoted to physical activity in the population over 65 years of age in the Valencian Community.

Methods

Cross-sectional descriptive analytical study of the data collected in the Health Survey of the Valencian Community on a total of 3,199 people over 65 years of age. The study variables were age, sex, educational level, marital status, social class, multimorbidity, severity index collected with the EQ-5D-5L tool, risk of poor mental health collected with the Goldberg general health questionnaire (GHQ-12), and perceived social, affective and confidential support collected with the Duke-Unc social support scale (Duke-UNC-11).

Results

All variables, except affective support, are significantly related to the time of physical activity performed by people older than 65 years. The severity index has a predictive capacity of 13.7% of physical activity performed and age is able to predict 1.2% of this variable.

Conclusion

Sex, age, education, social class, marital status, multimorbidity, risk of poor mental health or social support and confidentiality are related to the physical activity time of the Valencian population over 65 years of age. On the other hand, the variables severity index and age have been identified as variables capable of predicting up to 14.8% of the variance of the physical activity time variable in our study population.