bluuebunny/crossref_metadata_2025 huggingface dataset:
Dumbness revealing Fahr syndrome
Authors:   Agadir Psychiatric University Center, Morocco., M Ouhamou , H Laaraj ,   Agadir Psychiatric University Center, Morocco., I Bouaroua ,   Agadir Psychiatric University Center, Morocco., J Doufik ,   Department of Psychiatry, Inzegane Provincial Hospital, Morocco., K Mouhadi ,   Department of Psychiatry, Bensergao Military Hospital, Agadir, Morocco., I Rammouz ,   Health Sciences Research Laboratory, Faculty of Medicine, Ibn Zohr University, Agadir, Morocco.
Published: December 2021

Fahr’s syndrome is an anatomoclinical entity, defined by Theodor Fahr in 1930. It is determined by the presence of intracerebral, bilateral and symmetrical calcifications, non-arteriosclerotic, located in the basal ganglia. One of its main aetiologies is Pseudohypoparathyroidism (PHP), which shows resistance to the action of Parathyroid hormone (PTH), with mainly hypocalcemia and normal to high levels of PTH. The clinical manifestations of the disease do not correspond to any specific picture, but they can be dominated by various neuropsychiatric symptoms. We report the case of a 28-year-old young man who had a first psychotic attack a year ago, treated but without therapeutic observance, and who presented for mutism revealing Fahr syndrome. The evolution was marked by an improvement under conventional neuroleptics. Keywords: Fahr syndrome; chronic psychotic disorder; neuroleptic.
Origin of the coronavirus
Authors:   Emeritus Professor in Economics, Nagasaki University, Japan., Basu Dipak
Published: December 2021

Сoronavirus created all over the world a fear of death. How this virus was originated? The standard explanation from the Chinese was that in the wet market of Wuhan as there are Bat meat and Pangolean meat, virus was originated there and gradually spread all over Wuhan and other areas of China and then all over the world. However, serious doubts are now raised in the non-Chinese world. The reason is Bat was not sold in the wet market of Wuhan. There are active research going on in the Institute of Virology in Wuhan on various deadly virus, under the control of the Chinese military. Questions are raised whether accidentally virus was released from that Institute or it was deliberate.
Clinical evolution of hepatitis delta virus genotype 3 infection in patients from the Western Amazon, Brazil
Authors:   Laboratório de Virologia Molecular da Fundação Oswaldo Cruz Rondônia, Porto Velho, RO, Brazil., Costa Oliveira Suyane da , Castro Silva Eugênia de ,   Universidade Federal de Rondônia, Programa de Pós-Graduação em Biologia Experimental, Porto Velho, RO, Brazil, Zambenedetti Miriam Ribas ,   Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brazil., Pereira Soraya dos Santos ,   Universidade Federal de Rondônia, Programa de Pós-Graduação em Biologia Experimental, Porto Velho, RO, Brazil, Borghetti Ivo Alberto ,   Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brazil., Alves Vasconcelos Mariana Pinheiro ,   Ambulatório Especializado em Hepatites Virais do Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brazil., Pinheiro Borzacov Lourdes Maria ,   Ambulatório Especializado em Hepatites Virais do Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brazil., Marchini Fabricio Klerynton ,   Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brazil., Morello Luis Gustavo ,   Instituto de Biologia Molecular do Paraná, Curitiba, PR, Brazil., Krieger Marco Aurélio ,   Instituto Carlos Chagas-ICC/FIOCRUZ, Curitiba, PR, Brazil., Villalobos Salcedo Juan Miguel ,   Laboratório de Virologia Molecular da Fundação Oswaldo Cruz Rondônia, Porto Velho, RO, Brazil., Vieira Deusilene Souza ,   Laboratório de Virologia Molecular da Fundação Oswaldo Cruz Rondônia, Porto Velho, RO, Brazil., Rampazzo Rita de Cassia Pontello ,   Ambulatório Especializado em Hepatites Virais do Centro de Pesquisa em Medicina Tropical, Porto Velho, RO, Brazil.
Published: December 2021

Background: Chronic infection with the Hepatitis Delta Virus (HDV) is often associated with severe liver decompensation and fulminant hepatitis, but in some cases, it can present a stable clinical presentation. Objectives: This study evaluated the clinical evolution of HDV-3 carriers from an endemic region of the western Brazilian Amazon. Methods: Cross-sectional study was carried out with Anti-HDAg reagent patients, seen at an outpatient clinic specialized in viral hepatitis located in Rondônia, Brazil. Findings: A total of 19 patients, 68.4% male and 31.6% female, aged between 23 and 65 years old, were evaluated; 84.2% were clinically classified as carriers of the decompensated disease and 15.8% as carriers of the inactive disease. The results of the clinical evaluation were related to viral load; 30.8% had detectable viral RNA, and even though it was not possible to establish an association between the stage of the disease and persistent viral replication (p> 0.05), persistent viral replication was predictive of early evolution for liver cirrhosis. Conclusion: The results demonstrate the possibility that viral load can be used as a noninvasive hepatic marker in the clinical management of Hepatitis Delta. Keywords: chronic; hepatitis D; hepatitis delta virus; liver diseases.
Adjuvant radiotherapy in recurrent pleomorphic leiomyosarcoma of spermatic cord: A case report and literature review
Authors:   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Solazzo Angela Pia , Caivano Rocchina ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Benevento Ilaria ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Castaldo Giovanni ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Montagna Antonietta ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Rago Luciana ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Imbriani Giusy Carmen ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Bianculli Antonella ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Feoli Chiara ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Metallo Vito ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy., Fusco Vincenzo ,   Radiation Oncology Department, IRCCS CROB – via San Pio, 1 85028 Rionero in Vulture (Pz), Italy.
Published: December 2021

Pleomorphic leiomyosarcoma of spermatic cord is a very rare urologic disease, so there are no clear guidelines. The mainstay of treatment is surgery with wide excision margins. The role of adjuvant treatments, such as Chemotherapy (CHT) or Radiotherapy (RT), is not clear, due to the few data available in the literature. However, adjuvant treatments could be considered in patients with a high risk of local recurrence: R1 status after surgery and highgrade histology. We report the case of 68-year old man affected by recurrent pleomorphic leiomyosarcoma of spermatic cord right, who, in five years, underwent many surgical treatments for local recurrence, and also adjuvant CHT. The last surgery shows positive margins. Therefore, the patient receive adjuvant RT on the surgical bed and right inguinal nodes with a dose of 54 Gy in 27 fractions and VMAT technique. The treatment was well tolerated, the follow-up at 12 months is negative for local recurrence and show absence of toxicity. However a long-term follow-up is necessary to confirm the efficacy of radiotherapy on outcomes and especially on local control. Keywords: pleomorphic leiomyosarcoma; recurrence; positive margins; adjuvant radiotherapy
A rare case of mobile ball-like mass in right atrium associated with dilated cardiomyopathy
Authors:   Department of Cardiology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China., Dong Jing , Gao Yiqun ,   Department of Cardiology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China., Liang Shunji ,   Department of Cardiology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China., Deng Guorong ,   Department of Cardiology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China., Zhang Jian ,   Department of Cardiology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China., Wang Yunzhi ,   Department of Cardiology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China., Liu Li ,   Department of Cardiology, The Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning Province, China.
Published: December 2021

Mobile thrombus in the Right Atrium (RA) is a rare condition. Here, we described a case of a 59-year-old male who presented in emergency room with complaints of progressively worsening dyspnea for 7 years. He was normotensive, had elevated jugular venous pressure and clear lungs. ECG revealed ventricular tachycardia. After successfully electrical defibrillation, an urgent 2D echocardiogram was obtained and revealed the enlargement of all heart chambers and a ball-like, mobile mass in the right atrium. An emergent CT scan revealed no sign of pulmonary embolism. Based on morphological features on echocardiogram, we highly suspected it as RA thrombus. The patient was treated with anticoagulant therapy comprising of low molecular heparin and warfarin since he rejected surgical treatment. Repeat echocardiogram was performed 7 days after anticoagulant therapy and showed disappearance of the RA mass. He was subsequently maintained on warfarin (INR=2.4- 3.0) and other medications for heart failure. The patient was followed up as outpatient and kept in good clinical condition. We concluded that early recognition of this rare situation and prompt management can help in preventing life-threatening complications, and anticoagulant therapy was a therapeutic option for RA thrombus.
OSA: Special suspected in spontaneous cerebrospinal fluid leakage
Authors:   Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria-Varese, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy., Elli Fabrizia , Bernardini Elena ,   Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria-Varese, ASST Sette Laghi, Ospedale di Circolo, Varese, Italy., Battaglia Paolo ,   Head and Neck Surgery & Forensic Dissection Research Center, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy., Castelnuovo Paolo ,   Head and Neck Surgery & Forensic Dissection Research Center, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.
Published: December 2021

Objectives: Loss of Cerebrospinal Fluid (CSF-L) results from a rupture of the skull base and overlying meninges, and pathological communication between the subarachnoid space and the nasal or middle ear cavity. Recently, the pathogenesis has been linked with Intracranial Hypertension (IIH), elevated Body Mass Index (BMI) and Obstructive Sleep Apnea (OSA). Methods: A single institution retrospective study was conducted on 14 patients from our spontaneous CSFL series, which included 167 patients over a 15-year period from 2004 to 2019. All patients underwent to home respiratory polygraphy. Epidemiological and clinical data were reviewed. For the statistical analysis, the confidence interval for a proportion was defined, according to the methods described by RG Newcombe. Results: 14 patients, previously operated on duraplasty in our ENT department, were enrolled. They underwent to polygraphy. The data were compared with those derived from the literature and the results are neither in the range of the general population nor in the non-spontaneous CSFL Conclusion: OSA can increase Intracranial Pressure (ICP) and thus spontaneous CSF losses. However, OSA and BMI may not be independent. Therefore, further studies are needed to analyze the data in detail.
A rare cause of bladder outlet obstruction: Vesical diverticular calculus
Authors:   Department of Medicine, No: 9,10, Street-01, Near Columbus Public School, Model Colony, India., Rajdev Vivek
Published: December 2021

Vesical diverticula are herniations of the bladder mucosa and submucosa through the muscular wall of the bladder. A calculus in diverticulum is an unusual finding. It is usually secondary to bladder outlet obstruction [1]. The patient typically presents with lower urinary tract symptoms, lower abdominal pain or abdominal distention. The present case is a 64-year-old male with a giant vesical diverticulum calculus. Cystolithotomy was done with primary closure of bladder, with repair of bladder diverticulum. Post-operatively, he recovered well with improved lower urinary tract function.
Alternative conservative approach for tooth build-up in patients with special healthcare needs
Authors:   Dental Resident, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA., kakkar Mayank , Markonda Patnaik Vijay Rahul ,   Dental Preceptee, Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA., Malik Shaima ,   Department of Orthodontics and Dentofacial Orthopedics, Eastman Institute for Oral Health, Rochester, New York, USA., Singh Shilpa ,   Department of Orofacial Pain/TMD and Community Dentistry, Eastman Institute for Oral Health, Rochester. New York, USA., Planerova Adela ,   Department of General Dentistry, Eastman Institute for Oral Health, University of Rochester, NY, USA.
Published: December 2021

Purpose: The success of an artificial crown mainly depends on the biomechanical factors such as bonding capacity of cement between the crown and abutment tooth, and root strength of the abutment tooth. In this case series, we aim to provide insight on the potential use of the cast metal post and cost for patients with intellectual disabilities and severely compromised tooth structure. Material and methods: The first patient was a 41-year old male with the chief complaint of a dislodged porcelain fused metal (PFM) crown of tooth #20 (mandibular left second bicuspid). The patient was informed about the advantages, disadvantages, and risks of each option. After further consideration and discussion with the parents and the patient, we decided to rebuild the coronal tooth structure with the cast metal post and core and prosthetic restoration with the same crown. Patient satisfaction was measured on the visual analog scale as 10/10. The second case involves a 26-year old female, who presented with a chief complaint of chronic lingering pain on tooth #9. The tooth structure was extensively damaged and un-supportive of the ferrule, therefore, it was decided to build a metal post and core instead of a fiber post. The prosthetic restoration was made with a monolithic zirconia crown and the patient was followed up twice in 6 months and graded the satisfaction as 10/10 on a visual analog scale. Results: The most common type of posts used in dentistry has been cast post and cores in the last decade which generally includes an additional laboratory stage where a custom post is prepared according to the impression taken from the prepared post space. Conclusions: Both the presented cases explain an interesting advantage of restoring a root canal treated tooth with a metal post and core system which implies that in a prefabricated post and core restored tooth failure, a metal post, and core can potentially be the treatment of choice instead of extracting the tooth. Keywords: post and core; special needs; cast metal post.
Devil is in the detail, subtle signs of posterior reversible encephalopathy syndrome
Authors:   Department of Neurology, Hospital Universitari Doctor Josep Trueta, Girona, Spain., A Boix Lago , N Nersesyan ,   Department of Neuroradiology, Hospital Universitari Doctor Josep Trueta, Girona, Spain.
Published: December 2021

A 33-year-old woman presented to the hospital with convulsive seizure and hypertensive crisis. As differential diagnosis cortical venous thrombosis, ischaemic or haemorrhagic stroke, space occupying lesion, Posterior Reversible Encephalopathy Syndrome (PRES) and epileptic syndrome were considered. Antiepileptic and antihypertensives drugs were used as initial clinical management.
Diversity in the intestinal microbiota and the influence of delivery, dietary profile and nutritional status
Authors:   Nutritionist, MSc, Biosciences and Rehabilitation, Methodist University Centre – IPA., Valduga Franciele , Miri Malena Rostirola ,   Nutritionist, MSc, Biosciences and Rehabilitation, Methodist University Centre – IPA., Signori Daniela ,   Biomedical Scientist, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil., Costa Larissa Pereira da ,   Pharmacist, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre,Brazil., Martins Andreza Francisco ,   Pharmacist, Professor, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre,Brazil., Dani Caroline ,   Biomedical Scientist, Professor,Program in Biosciences and Rehabilitation at Methodist University Centre - IPA.
Published: December 2021

Objective: This research aimed to evaluate the nutritional status and influence on the dietary profile in the gut microbiota, in an attempt to identify possible effects of grape juice consumption among school children aged 6-10. Design: Anthropometric parameters (weight, height, Body Mass Index, waist circumference, triceps, and subscapular skinfold) weremeasured at baseline. A Food Frequency Questionnaire (FFQ) was carried out to evaluate the dietary profile. Feces were analyzed by culture methods and the alpha diversity was determined by the Shannon Index. Participants: 36 volunteer school children aged 6 to 10 years from two different cities in the South of Brazil. Main outcome measure: Gut microbiota diversity according to anthropometric parameters, nutrition profile and delivery patterns. Analysis: For statistical analysis, t or u test and correlation were used through the statistical software SPSS® version 22.0. Results: The volunteers presented a eutrophic nutritional status, but 41.7% in the City 2 were overweight. There was a significant difference in the consumption of polyphenols (p<0.003), microbiotadiversity, breastfeeding, and delivery patterns by city. However, the dietary profile does not include the portions of daily nutrients recommended in both cities. The volunteers from City 1 presented a greater alpha diversity, which may be related to higher micronutrient intake, breastfeeding, and predominant natural/vaginal delivery Conclusion: We observed that the normal delivery and the dietary profile seems to be important factors to the gut microbiota diversity in these children. Keywords: grape juice; dietary profile; gut microbiota.
Serum metabolic profiles changes observed post COVID-19 – Case report
Authors:   Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland., Toczylowska Beata , Slowikowska Anna ,   Medical University of Warsaw, Warsaw, Poland., Zieminska Elzbieta ,   Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland.
Published: December 2021

COVID-19 and its consequences are still not well known. The recovery from the infection is slow and many symptoms persist for a long time. We present the influence of the SARS-CoV-2 infection on serum metabolic profiles. The profiles were obtained using NMR spectroscopy from sera collected two years prior to the infection and twice during the recovery time from otherwise healthy subject. We performed comparisons of data collected pre- with postinfection. We present the metabolites which levels were decreased after COVID-19. These metabolites are involved in metabolic pathways like the TCA cycle, purine, glycine, arginine, proline, pyruvate, taurine, alanine, glutamate, glycerophospholipids, and cholesterol metabolism, as well as fatty acid and steroid hormone biosynthesis. Studies show changes in metabolic profiles during the recovery after COVID-19 that have not been observed by standard blood tests. Keywords: COVID-19; NMR spectroscopy; serum metabolite profiles.
CPAP - The choice of the mask does matter
Authors:   Multidisciplinary Sleep Unit, Pulmonology Department, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat (Barcelona), Spain., J Bordas-Martinez , N Salord ,   Multidisciplinary Sleep Unit, Pulmonology Department, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat (Barcelona), Spain., M Calvo ,   Multidisciplinary Sleep Unit, Pulmonology Department, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat (Barcelona), Spain., C Monasterio ,   Multidisciplinary Sleep Unit, Pulmonology Department, Bellvitge University Hospital, IDIBELL, Hospitalet de Llobregat (Barcelona), Spain.
Published: December 2021

We present a case of a patient with uncorrected Obstructive Sleep Apnea (OSA) despite good CPAP compliance with an oronasal mask who was referred to our tertiary care multidisciplinary sleep unit. We present here our systematic and comprehensive re-evaluation of the case, accompanied by an image of the polysomnography recordings that exemplify each step in the process, which concludes with a change to nasal CPAP and a transition to BPAP treatment. Keywords: obstructive sleep apnea; CPAP; BPAP; oronasal mask; nasal mask.
Cancer and tuberculosis: A lethal duo
Authors:   Associate Professor, Department of Respiratory Medicine, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India., Mishra Gyanshankar , Pachbhai Neha ,   Junior Resident, Department of Respiratory Medicine, Indira Gandhi Government Medical College, Nagpur, Maharashtra, India.
Published: December 2021

Cancer patients are at an increased risk of developing active Tuberculosis (TB) disease. Immunosuppression because of cancer or its treatment modalities, including chemo-radiotherapy, places these patients at an increased risk of developing active TB. We describe the case of a fifty-eight-year-old male patient who was diagnosed and treated for carcinoma larynx but later succumbed to pulmonary TB. Active screening and treatment for Latent TB Infection (LTBI) at the start of cancer treatment in these patients may potentially help reduce the reactivation risk of active TB disease among them. Keywords: tuberculosis; TB; cancer; malignancy; mortality; LTBI; chemo-radiotherapy
Iridocorneal endothelial syndrome: Short report
Authors:   Department A of Ophthalmology, Mohammed V University Souissi, Rabat, Morocco., S Benchakroun , N Taouri ,   Department A of Ophthalmology, Mohammed V University Souissi, Rabat, Morocco., A Tagmouti ,   Department A of Ophthalmology, Mohammed V University Souissi, Rabat, Morocco., LO Cherkaoui ,   Department A of Ophthalmology, Mohammed V University Souissi, Rabat, Morocco.
Published: December 2021

We report a case of a 42-year-old-woman, who presented to the ophthalmic consultation for decreased visual acuity complaints of blurred vision, altered pupillary shape since few months of her right eye. The clinical examination found a reduced visual acuity to counting fingers in the right eye and 20/20 in the left eye. intraocular pressures was 38 mm Hg OD and 14 mm Hg OS. Slit lamp examination of the right eye found: Corneal edema, iris atrophy with a deformation of the iris architecture and pupillary anomalies, with polycoria (Figure 1). The evaluation of the angle by gonioscopy found areas of broad synechiae anterior to Schwalbe’s line (Figure 2). While the examination of the left eye was normal (Figure 1B). The posterior segment examination was normal in both eyes. Specular microscopy confirmed the presence of unilateral endothelial pleomorphism and polymegathism. In our case of the retained diagnosis was iridocorneal endothelial syndrome
Chiari I malformation and Noonan’s syndrome: Shared manifestations of RASopathy
Authors:   epartment of Neurosurgery, University of Florida, Gainesville, USA., Still Megan , Miller Patricia ,   epartment of Neurosurgery, University of Florida, Gainesville, USA., Dodd William ,   epartment of Neurosurgery, University of Florida, Gainesville, USA., Moor Rachel ,   epartment of Neurosurgery, University of Florida, Gainesville, USA., Lucke-Wold Brandon ,   epartment of Neurosurgery, University of Florida, Gainesville, USA., Porche Ken ,   epartment of Neurosurgery, University of Florida, Gainesville, USA., Foote Kelly ,   epartment of Neurosurgery, University of Florida, Gainesville, USA.
Published: December 2021

Neurologic sequalae of Noonan syndrome have been postulated in the literature. A topic of significance is the role of RASopathy in the shared pathophysiology of Noonan Syndrome and Chiari I malformation. In this unique case report, we present a patient with concomitant Noonan Syndrome and Chiari I with 4th ventricular outflow obstruction. The case highlights the importance of close clinical suspicion in this patient population. We utilize the case to delve into intricacies of the known pathophysiology and encourage ongoing investigation. Keywords: Noonan syndrome; Chiari I malformation; RASopathy.
Anesthetic management “Abdominal Aortic Aneurysm” in the well-known case with Wolff-Parkinson-White syndrome
Authors:   Assistant Professor, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Asgari Sogol , Tafrishinejed Arash ,   Assistant Professor, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Behnaz Faranak ,   Associate Professor, Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Published: December 2021

Wolff-Parkinson-White syndrome is an electrophysiological disorder of the heart caused by pre-stimulation of an abnormal lateral pathway that can be asymptomatic or may be accompanied by palpitations or shortness of breath. We reported a case of a 66-yearold man with a history of Wolff-Parkinson syndrome who was transferred to the operating room for simultaneous nephrectomy due to RCC and abdominal aortic aneurysm. Managing the anesthesia of these patients is challenging because they are prone to life-threatening tachyarrhythmias. Observance of all necessary precautions to prevent tachyarrhythmias, balanced anesthesia, careful monitoring and preparation with the necessary drugs and equipment to treat any complication, is the cornerstone of a positive surgical outcome. Keywords: Wolff Parkinson white syndrome; abdominal aortic aneurysm; electrophysiological disorder; anesthetic management.
Mirror therapy to alleviate Phantom pain
Authors:   Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, New Delhi 110002, India., Gupta Abhishek Kumar , Gupta Rekha ,   Head of Department, Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, New Delhi 110002, India., Gill Shubhra ,   Associate Professor, Department of Prosthodontics, Maulana Azad Institute of Dental Sciences, New Delhi 110002, India., Grove Tanya ,   Final year Academic Resident, Department of Prosthodontics, Indraprastha Dental College and Hospital, Ghaziabad 201010, India.
Published: December 2021

Phantom pain is abnormal commotion of crushing, toes twisting, burning, tingling, cramping and shooting pain that is perceived in a body part that has been amputated or no longer exists. The amount of research in few decades has added enormous knowledge in better understanding of phantom pain. The theories of pain pathways have modified over time from mental theory to peripheral and core neural theories together motor-sensory cortical disassociation and tissue reorganization. In the generation of phantom pain, the role of mirror neurons has recently been steered. To alleviate the phantom pain, pharmacological therapy, physical therapy, TENS therapy, neuromodulation, surgical treatment, bio-integrative behavioural methods and Mirror Therapy has been suggested as treatment modalities. However, there hasn’t been a single treatment option until now. In several randomised controlled trials, mirror therapy is used to manage phantom arm pain and had better outcomes. Multidisciplinary approaches are used in the majority of effective clinical results. In this case report mirror therapy has been used to successfully reduce phantom pain. Keywords: mirror therapy; amputation; mirror neurons; phantom arm pain.
Kindler syndrome: A rare case report
Authors:   Junior Resident, Department of Dermatology, Venereology, Leprosy, Government Medical College and Hospital, Nagpur, Maharashtra, India., Chopkar Apoorva D , Malpani Sakshi S ,   Junior Resident, Department of Dermatology, Venereology, Leprosy, Government Medical College and Hospital, Nagpur, Maharashtra, India., Supekar Bhagyashree B ,   Junior Resident, Department of Dermatology, Venereology, Leprosy, Government Medical College and Hospital, Nagpur, Maharashtra, India., Mukhi Jayesh I ,   Assistant Professor, Department of Dermatology, Venereology, Leprosy, Government Medical College and Hospital, Nagpur, Maharashtra, India.,   Professor and Head of Department, Department of Dermatology, Venereology, Leprosy, Government Medical College and Hospital, Nagpur, Maharashtra, India.
Published: December 2021

Kindler Syndrome (KS) is a rare hereditary disorder characterized by acral blistering of infancy and childhood, photosensitivity, progressive poikiloderma, and cutaneous atrophy. We report this case of KS in a 4 year old female child on account of its rarity Keywords: Kindler syndrome; acral blistering; pokiloderma; photosensitivity
Dramatic demise of a pregnant woman in third trimester after presenting with persistent headache: An iatrogenic
Authors:   Department of Obstetrics & Gynecology, New Giza University School of Medicine, Egypt., Elkhateb Islam Tarek , Hisham Aldamsisi Mennah ,   New Giza University School of Medicine, Egypt., Mousa Abdalla ,   Department of Obstetrics & Gynecology, Kasr Alainy Hospital, Cairo University, Egypt.
Published: December 2021

A 31-years-old patient, pregnant at 32 weeks of gestation presented to our triage unit with complaint of gradually progressive persistent headache that started 1 day earlier and was unresponsive to all analgesics. Her history was insignificant for any major medical or surgical events and the pregnancy course was smooth as well. Her lab results and obstetric ultrasound were reassuring. During magnetic resonance imaging examination, the patient suddenly deteriorated after giving her an inhalational anaesthesia for sedation. She became unconscious. She was intubated, mechanically ventilated, and put-on cardiovascular support. Brain imaging then revealed Brain Stem (BS) herniation and diffuse brain oedema. She was announced dead with intrauterine foetal death. A late diagnosis of cerebral venous thrombosis was established. This caused BS herniation through increased intracranial pressure, which was iatrogenically augmented by administering inhalation anaesthesia. Keywords: cerebral vein; thrombosi; thrombophilia; pregnancy; headache; magnetic resonance imaging; brain stem herniation.
Infective endocarditis involving native aortic valve due to Burkholderia cepacia presenting as refractory heart failure in immunocompetent host: A case report
Authors:   Professor and Head/Senior Consultant Physician, Department of Medicine/ Department of Nephrology, Defence Services Medical Academy, No. (1) Defence Services General Hospital (1000-Bedded), Myanmar., Pyar Khin Phyu , Hla Sai Aik ,   Department of Medicine, No. (1) Defence Services General Hospital, 1000-Bedded, Myanmar, Hlaing Soe Win ,   Department of Medicine, No. (1) Defence Services General Hospital, 1000-Bedded, Myanmar, Min Soe ,   Department of Medicine, No. (1) Defence Services General Hospital, 1000-Bedded, Myanmar, Wunn Di ,   Department of Medicine, No. (1) Defence Services General Hospital, 1000-Bedded, Myanmar
Published: December 2021

A 44-year-old previously healthy gentle man presented with dyspnoea for three weeks which was more severe over 7 days. He had anaemia, sinus tachycardia, wide pulse pressure of 100 mmHg, heaving displaced apex beat, and features of aortic regurgitation with occasional crackles over both lung base. Echocardiogram revealed vegetations at aortic valve. He was initially treated as a case of infective endocarditis and left ventricular failure with amoxicillin, gentamycin and anti-failure treatment. However, heart failure was very refractory and even worsening; he expired five days after arrival to our hospital. Blood culture obtained after his death showed a growth of unusual organism Burkholderia cepacia. Keywords: infective endocarditis; aortic regurgitation; refractory heart failure; Burkholderia cepacia.
Yozlaşma, Kamusal Etkililik ve Ekonomik Büyüme: OECD Ülkeleri Üzerinde Bir Araştırma
Authors: GÜRLER HAZMAN Gülsüm
Published: December 2021

Kamusal etkililik, kamusal hizmet açısından amaçları elde etme başarısı olarak ifade edilmektedir. Kamu hizmetlerinin başarısının değerlendirilmesinde sunulan hizmet ile kamuya ve yararlanıcılarına sağlanan faydalara bakılmaktadır. Kamusal etkililik ile yolsuzluk ilişkisinin bilinmesi, yolsuzluğu etkileyen unsurların tahmin edilmesinde önemlidir. Bu çalışmanın amacı kamusal etkililiğin yozlaşma ve büyüme ile ilişkisini Türkiye dahil 33 OECD ülkesi için 2004-2015 verilerini kullanarak panel veri ile test etmektir. Çalışmadan elde edilen analitik sonuçlarına göre; kamusal etkililiğin yozlaşma (yolsuzluk algılama endeksi) üzerinde istatistiksel olarak anlamlı ve pozitif yönlü bir etkiye sahiptir. Yolsuzluk algı endeksi büyüdükçe yolsuzluk azaldığına göre; kamusal etkililik arttıkça yozlaşma da azalmaktadır. Kişi başına GSYİH ise yolsuzluk algılama endeksi üzerinde istatistiksel olarak anlamlı ve pozitif katsayıya sahip olduğundan, elde edilen sonuçlara göre ekonomiler büyüdükçe yozlaşmalar da azalmaktadır.
Diyanet İşleri Başkanlığı ve Dinî Söylemi -Diyanet Gazetesi ve Diyanet Aylık Dergi Başyazıları Örnekleminde-
Authors: ÜÇER Cenksu
Published: December 2021

Bu çalışmada Diyanet İşleri Başkanlığının dinî söylemi, Diyanet Gazetesi ve Diyanet Aylık Dergide yer alan ve Diyanet İşleri Başkanlarının (Vekili ve Yardımcılarının) kaleminden çıkan Başyazılar çerçevesinde ele alınmaktadır. Cumhuriyet’e geçişte de mevcut idarî yapı içerisinde yer alan Başkanlık, din hizmetlerini kamu görevi olarak yürütmekle yükümlü tutulmuştur. Başkanlık süreç içerisinde kurulan farklı idarî birimler vasıtasıyla mevzuatın yükümlü tuttuğu görevleri yerine getirmektedir. Başkanlığın hizmet politikalarının ve hassasiyetlerinin Diyanet İşleri Başkanlarının dilinden kamuoyu ile paylaşıldığı malumdur. Diyanet İşleri Başkanları 1950’li yıllardan beri düzenli olarak yayımlanan süreli yayınlarda Başyazılar ile topluma mesajlarını sistematik olarak iletmektedir. Bu itibarla bu yazıda Diyanet Gazetesi ve Diyanet Aylık Dergi Başyazıları merkeze alınarak Başkanlığın dinî söylemi hakkında bazı değerlendirmelerde bulunulmuştur. Başkanlığın dinî söyleminde Kanunla kendisine tanınan yetkilere bağlı olarak şekillenen iman esasları ve bazı inançlar, ibadet hayatı, birlik ve beraberlik, ahlak ve sosyal hayat merkezli bir çerçevenin söz konusu olduğu; bununla birlikte ahlak ve sosyal hayata ait konulara dair mesajların daha çok ön plana çıktığı dikkat çekmektedir.
Risalet Misyonunun Sürekliliği Söylemi Bağlamında Şia’da İmamet
Authors: BOZAN Metin
Published: December 2021

Hz. Peygamber’in vefatı akabinde vuku bulan hadiselerin ardından ortaya çıkan temel problemlerden birisi hilafet/İmamettir. Ehl-i Sünnet başta olmak üzere Şii olmayan mezhepler, her ne kadar dini anlamda özel önem atfetseler de nihayetinde onu beşerî bir görev/kurum olarak görmektedirler. Oysa İmamiyye Şiası, hilafet ve imamet kavramlarını birbirinden ayırmakta; hilafeti beşerî bir kurum olarak görüp saltanatla özdeşleştirirken imameti risaletin ilahi misyonu üzerinden içeriklendirmektedir. Bu bağlamda Hz. Muhammed ile Peygamberlik makamı nihayete erdiğinde ilahi risalet misyonu son bulmamış; imamet makamında devam etmiştir. İmamet makamının risalet misyonu üzerinden tanımlanması beraberinde “imamların neden Allah tarafından atanması gerektiği”, “imamların dini statüsü ve sahip olduğu nitelikler” gibi hususların bu dini söylem üzerinden geliştirilmesini getirmiştir. Bunun doğal sonucu olarak da tefsir, hadis, kelam ve fıkıh ilimlerinin imamet merkezli bir okumaya tabi tutulmuştur. Yine bazı fer’i meselelerde fıkhi hükümler imamet nazariyesiyle çelişmeyecek şekilde yorumlanmıştır. Bunun da ötesinde tarih, siyaset ve toplumsal hayat üzerinde de ilahi risalet misyonuna sahip imamet inancının güçlü izleri söz konusu olmuştur.
How do child sexual abuse live streaming offenders access victims?
Authors: Napier Sarah , Teunissen Coen
Published: December 2021

This study analysed chat logs obtained for seven offenders who committed 145 child sexual abuse (CSA) live streaming offences against 74 victims. The study found that offenders accessed victims online or by forming relationships with Filipino locals during trips to the Philippines, which would then move online and lead to CSA live streaming. A facilitator was involved in approximately 35 percent of offences. Facilitators were often female family members of victims (eg mothers and sisters). Some facilitators appeared to have experienced child sexual abuse as well. Although some offenders intentionally targeted children, it was also common for offenders to receive unsolicited offers of CSA live streaming from facilitators and victims. This suggests that some CSA live streaming offenders are ‘opportunistic’, and may be responsive to situational crime prevention and primary prevention measures such as messaging campaigns and online warning messages posted on specific sites where victims are targeted.
Study of Continuous and Intermittent Drying of Pear Through Mathematical and Diffusion Models
Authors: Lima Leiliane Silva Lopes , Silva Wilton Pereira da , Pereira Joan Carlos Alves , Silva Cleide Maria Diniz P. S. e
Published: December 2021

The methods for drying agricultural products are necessary to check the quality of the final product and feasibility of the process. The objective of this study was to perform the drying of pear by continuous and intermittent methods (α = 2/3) at two different temperatures, compare the two methods and describe the processes using mathematical and diffusion models to evaluate the saving of time and effective processing energy. For continuous drying, Page model was the one which best fitted to the experimental data, with highest coefficient of determination and lowest chi-square. Regarding intermittent drying Page model was also the one which best fitted to the experimental data for the two temperatures studied. When comparing the drying methods studied, it was found that intermittent drying produced a similar and considerably better effect on the energy saving aspect, compared with continuous drying: 41.7% at 50 °C and 25.8% at 70 °C. The effect of time intervals with the product out of the dryer, during the intermittent drying process, was reflected in the increase in the diffusion coefficient, so that the transport of moisture occurred more quickly for this type of drying, which contributes to justify the reduction of effective operating time and increased dry product quality.
Influence of Institutional Inclusive Policy on Curriculum Adaptation and Participation of Students With Disabilities on Academic Activities in Public Universities in Kenya
Authors: Karanja David Njuguna , Musyoka-Kamere Isabella , Wawire Violet
Published: December 2021

Globally, it is estimated that close to 140 million learners are out of school and among them are those with disabilities as a result of physical, mental and sensory impairments. Out of that number, it is further estimated that 70% of learners with disabilities can attend and benefit from regular education programs as long as effective institutional changes that are guided by sound inclusive policies are done. So, this study examined institutional inclusive policies on curriculum adaptation, and how the policies affect the way Students with Disabilities participate academically. The study was guided by the social model theory of disability. A descriptive research design and a comparative approach were used to scientifically compare curriculum adaptation in Kenyatta and Jomo Kenyatta University of Agriculture and Technology Universities which were purposively chosen as the sample owing to their longer establishment. Lecturers teaching and Students with Disabilities enrolled in different programs were targeted. The two registrar academics in charge of admission and the two coordinators of the disability offices from both universities were purposively selected. Data collection instruments were interviews, questionnaires, observation guide, focus group discussions and document analysis. The findings showed that the appropriate adaptation of the University curriculum has not been fully made to respond to the diverse academic needs of all learners with various disabilities.
KNN Algorithm Used for Heart Attack Detection
Authors: Bah Ibrahima
Published: December 2021

Machine Learning, a branch of artificial intelligence, has become more accurate than human medical professionals in predicting the incidence of heart attack or death in patients at risk of coronary artery disease. In this paper, we attempt to employ Artificial Intelligence (AI) to predict heart attack. For this purpose, we employed the popular classification technique named the K-Nearest Neighbor (KNN) algorithm to predict the probability of having the Heart Attack (HA). The dataset used is the cardiovascular dataset available publicly on Kaggle, knowing that someone suffering from cardiovascular disease is likely to succumb to a heart attack. In this work, the research was conducted using two approaches. We use the KNN classifier for the first time, aided by using a correlation matrix to select the best features manually and faster computation, and then optimize the parameters with the K-fold cross-validation technique. This improvement led us to have an accuracy of 72.37% on the test set.
The power of story-telling for water and climate
Authors: Powell Bronwyn , Ransom Sarah
Published: December 2021

Looking back on COP26, we argue that there is power in telling stories about adaptation to water-related climate change impacts in Australia and the Pacific.
CLINICAL CASE: MICROSCOPIC POLYANGIITIS AS ONE OF THE MAIN VARIANTS OF PULMONARY-RENAL SYNDROME
Authors: Жанузаков М.А. , Бапаева М.К. , Шурина А.Ж. , Утежанов Э.М.
Published: December 2021

Клинические проявления микроскопического полиангиита многообразны, что затрудняет своевременную диагностику и соответственно адекватное лечение. Цель: привлечь внимание терапевтов, пульмонологов, нефрологов к своевременному выявлению легочно-почечного синдрома и установлению его нозологической основы, в частности микроскопического полиангиита на примере клинического случая. Материалы и методы: проведены обследование пациента с микроскопическим полиангиитом и дифференциальная диагностика в рамках легочно-почечного синдрома. Результаты: на основании анамнеза заболевания, результатов клинического и дополнительных методов исследования пациента, установлен диагноз микроскопического полиангиита. Выводы: для ранней диагностики микроскопического полиангиита необходима настороженность при возникновении легочно-почечного синдрома в виде сочетания гломерулонефрита и геморрагического альвеолита на фоне сосудистой пурпуры.

Clinical manifestations of microscopic polyangiitis are diverse, which complicates timely diagnosis and, accordingly, adequate treatment. Goal: to draw the attention of therapists, pulmonologists, nephrologists to the timely detection of pulmonary-renal syndrome and the establishment of its nosological basis, in particular microscopic polyangiitis by the example of a clinical case. Materials and methods: an examination of a patient with microscopic polyangiitis and differential diagnosis within the framework of pulmonary-renal syndrome were carried out. Results: based on the anamnesis of the disease, the results of clinical and additional research methods of the patient, the diagnosis of microscopic polyangiitis was established. Conclusions: for early diagnosis of microscopic polyangiitis, alertness is necessary in the event of pulmonary-renal syndrome in the form of a combination of glomerulonephritis and hemorrhagic alveolitis against the background of vascular purpura.
RADIATION DIAGNOSTICS OF STRESS BONE RESTRUCTURING
Authors: Мухамеджанов К.Х.
Published: December 2021

В данной статье представлены результаты клинических проявлений и рентгенологических исследований, перестройки костной ткани. Результаты наших исследований показали, что обычная рентгенография не решает всей проблемы диагностики стрессовых переломов напряжения. Мы в данной публикации выделяем те случаи, когда обычная рентгенография не в силах решить проблему диагностики и требует использования дополнительных методов лучевой диагностики. Исследование проведено на базе ЦГКБ г. Алматы. Под нашим наблюдением находились 11 (100%) больных, у которых заподозрено наличие перестройки костей. У 6 (54.5%) больных данные рентгенологического исследования указывали, на наличие стрессовой перестройки кости у 5 (45,5%) больных признаки были сомнительными. Применение компьютерной томографии (КТ) и динамическое рентгенологическое исследование позволило установить диагноз стрессовой перегрузки костей.

This article presents the results of clinical manifestations and X-ray studies of the bone remodeling. The results of our research have shown that conventional radiography does not solve the entire problem of diagnosing stress fractures of tension. In this publication, we highlight those cases when conventional radiography is unable to solve the diagnostic problem and requires the use of additional methods of radiation diagnostics. The research was carried out on the basis of the Central City Clinical Hospital of Almaty. We observed 11 (100%) patients in whom the presence of bone remodeling was suspected. In 6 (54.5%) patients, X-ray examination data indicated that the presence of stress bone remodeling in 5 (45.5%) patients were dubious. The use of computed tomography analysis (CT) and dynamic X-ray examination made it possible to establish the diagnosis of bone stress overload.