bluuebunny/crossref_metadata_2025 huggingface dataset:
Dinlerde Kurtarıcı Düşüncesini İfade Eden Kavramlar Üzerine Bir İnceleme
Authors: Oruç Muhammed Cihat
Published: January 2023

Kurtarıcı beklentisi, hemen hemen bütün din ve kültürlerde farklı isim ve özelliklerle olsa da aynı amaca yönelik olarak yer alan müşterek bir düşünce tarzıdır. Bu düşünce; birçok dinin ana unsurlarından biri olup, çeşitli din, mitolojik anlatı ve kültürlerde oldukça güçlü bir inanç konusunu oluşturmaktadır. Dinlerde ortak bir fenomen olarak yer alan kurtarıcı düşüncesi, her dinsel gelenekte aralarında etimolojik bir birlik olmayan farklı kelime ve kavramlar ile ifade edilmektedir. Bu çalışma, çeşitli dinlerde görülen kurtarıcı beklentisini karşılayan kavramların etimolojik kökenlerini araştırarak aralarındaki anlamsal bağ, benzerlik ve farklılıklar üzerinde değerlendirmeler ve karşılaştırmalar yapmayı amaç edinmiştir. Ancak tüm dinleri ele almak makalenin sınırlarını aşacağından bu çalışma, Hinduizm, Budizm, Zerdüştîlik, Yahudilik, Hıristiyanlık ve İslam olmak üzere altı dinde yer alan kurtarıcı düşüncesine odaklanmaktadır. Bu dinlerin eskatolojik fikirleri bağlamında kurtarıcı beklentilerini ifade eden kavramlar hakkında kutsal metin ve tarihsel kaynaklar kullanılarak etimolojik kavramsal ve anlamsal benzerlik ile farklılıkları ortaya konularak bütüncül bir çalışma sunulmak istenmektedir. Bu şekilde dinler ve kültürler arası kurtarıcı fikrini karşılayan kavramlar üzerine bir analiz sunularak bu fenomenin daha iyi anlaşılmasına katkı sağlanması umulmaktadır.
Umudu Yordayan Bazı Sosyo-Demografik Değişkenler ve Dindarlık-Umut İlişkisi
Authors: Kandemir Fatih
Published: January 2023

Bu çalışmanın amacı, umut ve dindarlık arasındaki ilişkileri incelemektir. Umut, insan için varoluşsal bir değere sahiptir. Zira bireyin, karşılaştığı olumsuz yaşam olaylarından yara almadan ya da minimum hasarla kurtulmasına aracılık eden umut, birçok değişkenden etkilenebilmektedir. Bu bağlamda umut, sadece iyimserlik, sabır gibi psiko-sosyal değişkenlerden değil aynı zamanda yaş, cinsiyet, medenî durum, sosyo-ekonomik düzey ve mükemmeliyetçilik kişilik özellikleri gibi sosyo-demografik değişkenlerden de etkilenebilmektedir. Umudu etkileyebilen bir diğer değişken ise psiko-teolojik kökene sahip olan dindarlıktır. Çünkü dindarlık, doğası itibarıyla umudu besleyen önemli bir motivasyon kaynağıdır. Bu durumun, dindar bireyin ruh sağlığı açısından önemli çıktılarının olduğu düşünülmektedir. Bu çalışmanın iki temel hareket noktasından birisi budur. Bir diğeri ise, ruh sağlığı bozulmuş olan bireylere hizmet veren uzmanlara, bu hizmetlerinin daha etkin sonuçlar üretebilmesi için, danışanlarının dinî inançlarının bu gücünden yararlanabilecekleri konusunda bir farkındalık sağlamaktır. Bu bağlamda çalışma, ilgili değişkenler arasındaki ilişkileri incelemiş olan araştırmaların verilerinden yararlanılarak yürütülmüştür. Çalışma sonuçları, genel olarak, bireylerin dindarlık düzeylerine paralel olarak umut düzeylerinin de yükseldiğini bunun ise onların ruh sağlıklarına olumlu yansıdığını göstermektedir.
Gülbâng Kelimesinin 'Temel Anlamı' ve Farsça Kaynaklardan Türkçeye Aktarımında Kullanılan Kelimeler (Hâfız Dîvânı Örneği)
Authors: Aydın Kaim Mehtap
Published: January 2023

Yüzyıllar ötesinden gelip bugün hâlâ varlığını koruyan bir kelimenin anlamının genişlemesi yahut daralması pek tabiidir. Kelimenin yaşadığı serüven dikkate alınmadan bilhassa yazılış tarihi eski metinlerde kelimeye bugünden mana vermek okuyucunun kelimeyi yanlış anlama ihtimalini yükseltir. Sözcük terimleşmiş ve terimleşme sonrasında “gerçek anlamı”yla da dil içinde varlığını sürdürmüşse sözcüğün yanlış anlaşılma ihtimali daha da artmaktadır. Bu türden bir kelime olup edebî bir türe ad olan “gülbâng” kavramının, “şekli ve muhtevası belli bir dua metni”ni ifade etmeden önceki anlamını kavramak, kavramın geçtiği metinleri de sıhhatle anlamamızı sağlayacaktır. Bu makalede gülbâng kavramının “köken bilgisi” incelenmiş ve kavramın anlamına ilişkin farklı görüşler değerlendirilmiştir. Farsçadan Türkçeye geçen kelimenin, Hâfız Dîvânı özelinde, Türkçede hangi kavramlarla karşılandığı ortaya koyulmuştur. Kelimenin hangi saikle bir dua türüne ad olduğu açıklanmıştır.
Mu‘tezile Kelâmında Ahiret Halleri (Eskatoloji): İbnü’l-Melâhimî Örneği
Authors: Özerol Mehmet Fatih
Published: January 2023

İnsanın ölümü ile birlikte başlayan kabir hayatında ve sonrasında ahirette meydana gelecek olaylar semʻiyyât başlığı altında ele alınmıştır. Semʻiyyât ilkesi, ilâhiyyât ve nübüvvât ilkeleri ile birlikte kelâm ilminde “usûl-i selâse” den biri olup; meleklere iman ve ahirete iman konularını kapsar. Makalede ahiret hayatının ilk aşaması olan kabirdeki sorgu ve sonrasında insanın ahirette yaşayacağı olaylara dair son dönem Mu‘tezilî kelâmcılarından İbnü’l-Melâhimî’nin görüşleri ele alınacaktır. Onun semʻiyyât konularını anlama hususunda yöntem olarak nasların zahirine bağlı kaldığı görülmektedir. Özellikle kabir azabı, sırat, mîzan gibi konuları ilgili âyet ve hadislerde geçtiği üzere zahirî anlamlarıyla olduğu gibi kabul etmiştir. Bu tür uhrevî olay ve kavramların müşâhede yani gözlem metodu ile değil, şerʻî delil ile ispatlanması gerektiğini söylemiştir. Mu‘tezilî kelâmda aklî bir yöntem olarak kabul edilen te’vil, İbnü’l-Melâhimî’nin de ahirete ilişkin olay ve kavramların anlaşılması ve değerlendirilmesinde yer yer başvurduğu bir yöntemdir. Ancak O, ahiret konularında temel dayanak olarak nassı kabul etmiştir. Bu konular hakkında yaptığı te’villerde Kur’an âyetleri ve hadis rivayetlerinin ifade ettiği literal anlamı göz önünde bulundurmuştur.
İslam Ceza Hukuku ile Çağdaş Ceza Hukukundaki Kusur İlkesinin Mukayesesi
Authors: Aykul Abdulmuid
Published: January 2023

Çağdaş ceza hukukunun önemli ilkelerinden biri olarak kabul edilen kusur ilkesi, “kusursuz ceza olmaz. (Latincesi: Nulla poena sine culpa)” anlayışına dayanmaktadır. Kısaca, suçun en önemli iki unsuru olan fiil ile fâili arasındaki mânevî ilişki olarak tanımlayabileceğimiz kusurluluk ceza sorumluluğunun da temeli olarak kabul edilir. Zira bir fiilin suç olma vasfı o fiili işleyen fâilin kusurlu bir hareketi sonucunda meydana gelmektedir. Fâilin hiçbir kusuru olmaksızın meydana gelen fiiller -istisnai haller bulunmakla birlikte- suç olma vasfını kazanmaz. Bu açıdan bakıldığında kusurluluk suçun sübjektif unsurunu teşkil etmektedir. “Kusursuz suç olmaz” prensibinin, batı ceza hukuklarında yerini alması İslam ceza hukukuna göre oldukça geç bir zamanda meydana gelmiştir. Kur’ân-ı Kerim’in nüzûlü ile birlikte özellikle kısas suç ve cezalarında kast-taksir ayrımı yapılmış, kusurluluğun derecelenmesine göre cezalarda da farklılaşma öngörülmüştür. Kusursuz suçun olmayacağı öngörülmesine rağmen işlenen fiil sonucunda meydana gelen zararların telafi edilebilmesi için tazmin yükümlülüğü kabul edilmiştir. Bu itibarla İslam ceza hukukunda kusursuz sorumluluk hükümleri sebep sorumluluğu çerçevesinde tazmin karakterlidir.
Republicans for Labor: State-level Labor Power and Republican Senate Behavior
Authors: R. Daneri Danny
Published: January 2023

Despite a half-century of decline in membership and political influence, unions still play a prominent role in lobbying for congressional policy. For much of post-war history, policies around labor and employment have divided along partisan lines, seemingly confining labor’s influence to politicians in the Democratic Party. In this paper, we construct a dataset of labor and employment legislation from 1970 to 2020 to examine the influence of state-level union density on Republican Senators’ votes over the past half-century. We use a two-stage ordinary least squares model with a novel instrument to provide causal estimates of the effect of unionization on Senator voting behavior. The results suggest that the percentage of employed workers who are in unions in a state is strongly predictive of whether Republicans will defect in favor of labor policies supported primarily by Democrats.
First record of one family and two genera of pseudoscorpions (Arachnida: Pseudoscorpiones) from Hispaniola
Authors: Carrero Jiménez Solanlly , Santos Gabriel de los
Published: January 2023

The Family Neobisiidae, the genera Microbisium Chamberlin, 1930 and Ideoblothrus Balzan, 1891 (Family Syarinidae), as well as the species M. parvulum (Banks, 1895) and I. pygmaeus (Hoff, 1964), are recorded for the first time in Hispaniola. These records are based on three males, four females and two deutonymps collected in the Provinces La Vega and Barahona, and the National District, Dominican Republic. With these findings, the list of pseudoscorpions known from Hispaniola is increased to 14 families, 32 genera, and 39 species.
Unutma, Anımsama, Yok Sayma ve Pazarlık Üzerine: Anıtsal Bir Heykel Olarak Barış Kızı Heykeli
Authors: Danışan Artan Esengül
Published: January 2023

Asya Pasifik Savaşı (1932-1945) sırasında hâlihazırda sömürge ülkesi olmasından dolayı kadın “temin” etmenin kolay olduğu ülke Kore kadınları çoğunlukta olmak üzere sayıları yüzbinleri bulan Doğu Asya kadınları Japonya’nın askeri üslerinde seks kölesi olmaya zorlanmış, sistematik tecavüze ve şiddete uğramışlardır. 1990 yılında ilk kez Koreli Kim Hak Sun’un bir TV programında konuşması ile yıllar süren suskunluk bozulmuş, bu şiddete maruz kalmış birçok kadın konuşmak üzere öne çıkmıştır. Bir özür ve tazminat hareketi ile yola çıkan “comfort women” olmak zorunda bırakılmış kadınlar büyük destek görürken; bu destekler kendilerini ve yaşadıklarını temsil eden heykellerle ulusötesi bir harekete dönüşmüştür. Makale söz konusu heykellerden ilki olan Barış Kızı Heykeli üzerinden bir temsil mekânının toplumsal ve bireysel hafızada etkisini hafıza, mekân ve temsil mekânı kavramları üzerinden tartışmayı amaçlamıştır. Bu bağlamda makalenin temel argümanı heykel sanatı ile bir temsil mekânı yaratılabileceği ve bu temsiliyetin toplumsal hafızayı şekillendirmek üzere kurgulanmasının mümkün olduğudur.
Feminist Şehir: Bir Saha Rehberi
Authors: Levent Fatma
Published: January 2023

Kitap Derlemesi:Leslie Kern (2020). Feminist Şehir: Bir Saha Rehberi (çev. B.S. Aydaş). İstanbul: Sel Yayıncılık. 197 sayfa. ISBN: 978-605-772-837-1
Saraybosna Havası: Bir Gündelik Hayat Etnografisi
Authors: Cangöz İncilay , Gönç Şavran Temmuz
Published: January 2023

Kitap Derlemesi:Halide Velioğlu (2022). Saraybosna Havası: Bir Gündelik Hayat Etnografisi. İstanbul: İletişim Yay.  261 sayfa. ISBN: 978-975-053-174-3
Gold nanoplatform for near-infrared light-activated radio-photothermal gas therapy in breast cancer
Authors: Zuo Shuting , Wang Zhenyu , Zhao Liping , Wang Jing
Published: January 2023

Although radiotherapy is one of the most common treatments for triple-negative breast cancer (TNBC), it frequently has unsatisfactory therapeutic outcomes due to the radiation resistance of tumor tissues. Therefore, a synergistic strategy is urgently needed to increase therapeutic responses and prolong patient survival. Herein, we constructed gold nanocages (GNCs) loaded with a hyperpyrexia-sensitive nitric oxide (NO) donor (thiolate cupferron) to integrate extrinsic radiosensitization, local photothermal therapy, and near-infrared-activated NO gas therapy. The resulting nanoplatform (GNCs@NO) showed a high photothermal conversion efficiency, which induced the death of cancer cells and facilitated rapid NO release in tumor tissues. The radiosensitizing efficacy of GNCs@NO was further demonstrated in vitro and in vivo. Importantly, the released NO reacted with the reactive oxide species induced by radiotherapy to produce more toxic reactive nitrogen species, exerting a synergistic effect to improve anticancer efficacy. Thus, GNCs@NO demonstrated excellent effects as a combination therapy with few adverse effects. Our work proposes a promising nanoplatform for the radio/photothermal/gas treatment of TNBC.
Synovial sarcoma of the head and neck: A review of reported cases on the clinical characteristics and treatment methods
Authors: Quan Hongzhi , Sreekissoon Senjeet , Wang Yan
Published: January 2023

Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma that occurs predominantly in older children and young adults in their thirties. It is usually very challenging to diagnose and treat synovial sarcoma in the head and neck region. The purpose of this review is to investigate the clinical manifestations and different treatment methods in the management of primary synovial sarcoma of the head and neck. HNSS has an aggressive nature and poor prognosis. Surgical resection, radiotherapy, and chemotherapy are the primary treatment methods. Typically, surgical resection with negative margins remains the foundation of therapy, which is not very easily achieved in the head and neck due to its complex anatomical structure and the presence of many blood vessels and nerves. However, synovial sarcoma has a high recurrence rate, so aggressive management and close follow-up are warranted for the optimal outcome.
Evaluation of the anti-inflammatory, antioxidant, and cytotoxic potential of Cardamine amara L. (Brassicaceae): A comprehensive biochemical, toxicological, and in silico computational study
Authors: Basit Abdul , Ahmad Saeed , Khan Kashif ur Rehman , Aati Hanan Y. , Sherif Asmaa E. , Ovatlarnporn Chitchamai , Khan Safiullah , Rao Huma , Arshad Muhammad Adeel , Shahzad Muhammad Nadeem , Perveen Shagufta
Published: January 2023

Introduction:Cardamine amara L. (Brassicaceae) is an important edible plant with ethnomedicinal significance. This study aimed at evaluating the phytochemical composition, anti-inflammatory, antioxidant and cytotoxicity aspects of the hydro-alcoholic extract of C. amara (HAECA).

Methods: The phytochemical composition was evaluated through total phenolic contents (TPC), total flavonoid contents (TFC) determination and UPLC-QTOF-MS profiling. Anti-inflammatory evaluation of HAECA was carried out through the carrageenan induced paw edema model. Four in vitro methods were applied in the antioxidant evaluation of HAECA. MTT assay was used to investigate the toxicity profile of the species against human normal liver cells (HL7702), human liver cancer cell lines (HepG2) and human breast cancer cell lines (MCF-7). Three major compounds (Gentisic acid, skullcapflavone and conidendrine) identified in UPLC-Q-TOF-MS analysis were selected for in silico study against cyclooxygenase (COX-I and COX-II).

Results and Discussion: The findings revealed that HAECA is rich in TPC (39.32 ± 2.3 mg GAE/g DE) and TFC (17.26 ± 0.8 mg RE/g DE). A total of 21 secondary metabolites were tentatively identified in UPLC-Q-TOF-MS analysis. In the MTT cytotoxicity assay, the extract showed low toxicity against normal cell lines, while significant anticancer activity was observed against human liver and breast cancer cells. The carrageenan induced inflammation was inhibited by HAECA in a dose dependent manner and showed a marked alleviation in the levels of oxidative stress (catalase, SOD, GSH) and inflammatory markers (TNF-α, IL-1β). Similarly, HAECA showed maximum antioxidant activity through the Cupric reducing power antioxidant capacity (CUPRAC) assay (31.21 ± 0.3 mg TE/g DE). The in silico study revealed a significant molecular docking score of the three studied compounds against COX-I and COX-I. Conclusively the current study encourages the use of C. amara as a novel polyphenolic rich source with anti-inflammatory and antioxidant potential and warrants further investigations on its toxicity profile.
Ligand and structure-based approaches for the exploration of structure–activity relationships of fusidic acid derivatives as antibacterial agents
Authors: Zheng Wende , Tu Borong , Zhang Zhen , Li Jinxuan , Yan Zhenping , Su Kaize , Deng Duanyu , Sun Ying , Wang Xu , Zhang Bingjie , Zhang Kun , Wong Wing-Leung , Wu Panpan , Hong Weiqian David , Ang Song
Published: January 2023

Introduction: Fusidic acid (FA) has been widely applied in the clinical prevention and treatment of bacterial infections. Nonetheless, its clinical application has been limited due to its narrow antimicrobial spectrum and some side effects.

Purpose: Therefore, it is necessary to explore the structure–activity relationships of FA derivatives as antibacterial agents to develop novel ones possessing a broad antimicrobial spectrum.

Methods and result: First, a pharmacophore model was established on the nineteen FA derivatives with remarkable antibacterial activities reported in previous studies. The common structural characteristics of the pharmacophore emerging from the FA derivatives were determined as those of six hydrophobic centers, two atom centers of the hydrogen bond acceptor, and a negative electron center around the C-21 field. Then, seven FA derivatives have been designed according to the reported structure–activity relationships and the pharmacophore characteristics. The designed FA derivatives were mapped on the pharmacophore model, and the Qfit values of all FA derivatives were over 50 and FA-8 possessed the highest value of 82.66. The molecular docking studies of the partial target compounds were conducted with the elongation factor G (EF-G) of S. aureus. Furthermore, the designed FA derivatives have been prepared and their antibacterial activities were evaluated by the inhibition zone test and the minimum inhibitory concentration (MIC) test. The derivative FA-7 with a chlorine group as the substituent group at C-25 of FA displayed the best antibacterial property with an MIC of 3.125 µM. Subsequently, 3D-QSAR was carried on all the derivatives by using the CoMSIA mode of SYBYL-X 2.0.

Conclusion: Hence, a computer-aided drug design model was developed for FA, which can be further used to optimize FA derivatives as highly potent antibacterial agents.
Susceptibility profile of blaOXA-23 and metallo-β-lactamases co-harbouring isolates of carbapenem resistant Acinetobacter baumannii (CRAB) against standard drugs and combinations
Authors: Sharma Swati , Banerjee Tuhina , Yadav Ghanshyam , Kumar Ashok
Published: January 2023

Background

The rapid emergence of carbapenem resistant Acinetobacter baumannii (CRAB) has resulted in an alarming situation worldwide. Realizing the dearth of literature on susceptibility of CRAB in genetic context in the developing region, this study was performed to determine the susceptibility profile against standard drugs/combinations and the association of in-vitro drug synergy with the prevalent molecular determinants.

Methods and findings

A total of 356 clinical isolates of A. baumannii were studied. Confirmation of the isolates was done by amplifying recA and ITS region genes. Susceptibility against standard drugs was tested by Kirby Bauer disc diffusion. Minimum inhibitory concentration (MIC), MIC50 and MIC90 values against imipenem, meropenem, doripenem, ampicillin/sulbactam, minocycline, amikacin, polymyxin B, colistin and tigecycline was tested as per guidelines. Genes encoding enzymes classes A (blaGES, blaIMI/NMC-A, blaSME, blaKPC), B (blaIMP, blaVIM, blaNDM) and D (blaOXA-51,blaOXA-23 and blaOXA-58) were detected by multiplex polymerase chain reaction. Synergy against meropenem-sulbactam and meropenem-colistin combinations was done by checkerboard MIC method. Correlation of drug synergy and carbapenemase encoding genes was statistically analyzed.

Results

Of the total, resistance above 90% was noted against gentamicin, ciprofloxacin, levofloxacin, ceftazidime, cefepime, ceftriaxone, cotrimoxazole and piperacillin/tazobactam. By MIC, resistance rates from highest to lowest was seen against imipenem 89.04% (n=317), amikacin 80.33% (n=286), meropenem 79.49% (n=283), doripenem 77.80% (n=277), ampicillin/sulbactam 71.62% (n=255), tigecycline 55.61% (n=198), minocycline 14.04% (n=50), polymyxin B 10.11% (n=36), and colistin 2.52% (n=9). CRAB was 317 (89.04%), 81.46% (n=290) were multidrug resistant and 13.48% (n=48) were extensively drug resistant. All the CRAB isolates harboured blaOXA-51 gene (100%) and 94% (n=298) blaOXA-23 gene. The blaIMP gene was most prevalent 70.03% (n=222) followed by blaNDM, 59.62% (n=189). Majority (87.69%, 278) were co-producers of classes D and B carbapenemases, blaOXA-23 with blaIMP and blaNDM being the commonest. Synergy with meropenem-sulbactam and meropenem-colistin was 47% and 57% respectively. Reduced synergy (p= <0.0001) was noted for those harbouring blaOXA-51+blaOXA-23with blaNDM gene alone or co-producers.

Conclusion

Presence of blaNDM gene was a significant cause of synergy loss in meropenem-sulbactam and meropenem-colistin. In blaNDM endemic regions, tigecycline, minocycline and polymyxins could be viable options against CRAB isolates with more than one carbapenemase encoding genes.
Detection and homology analysis of carbapenem resistant Acinetobacter baumannii resistance gene
Authors: Huang Hua-Liang , Li Yue-Yu , Guo Hong-Bo
Published: January 2023

Objective

To explore the carrying status and homology of carbapenem resistant Acinetobacter baumannii (CRAB) in our hospital.

Methods

From January 2015 to December 2017, 52 strains of acinetobacter baumannii isolated from the bacteria room of the clinical laboratory of Baogang hospital in Inner Mongolia were selected as the research object. K-B disk diffusion method and Vitek-2 were used to determine the drug sensitivity of Acinetobacter baumannii. The drug resistance gene was detected by polymerase chain reaction (PCR) and its homology was analyzed by pulsed field gel electrophoresis (PFGE).

Results

Except for Cefoperazone/sulbactam, other antibiotics were resistant to ab. The detection rate of drug resistance gene class C β-lactamases (ADC) was 100%, and the higher detection rates of other drug resistance genes were class D β-lactamases (OXA)-51 (36 strains, 90.0%),disinfectant gene qacE△1-sull (32 strains, 80.0%), and klebsiella pneumoniae carbapenemase (KPC) gene was not detected. 2-8 drug resistance genes were detected in each CRAB strain, and the strains with 6 drug resistance genes were the most (15 strains, 37.5%); Among the detected drug-resistant gene combinations, ADC+OXA-23 + OXA-51 gene was detected at the same time (29 strains, 72.5%), followed by ADC+ intl1 + qacE △ 1-sull gene (26 strains, 65.0%), ADC + qacE △ 1-sull + ant (3 ‘‘) -i gene (19 strains, 47.5%), and 11 strains (27.5%). There were 19 different types in PFGE homology test, each type was 1-9 strains, including 9 strains of A5 type and 8 strains of A18 type, mainly from intensive care unit.

Conclusion

CRAB in the hospital is highly resistant to common clinical antibiotics. OXA-23 and OXA-51 genes are most likely to be the main factors causing drug resistance of Acinetobacter baumannii in the hospital. Homology analysis showed that there was CRAB nosocomial infection transmission in different wards of the hospital.
A discourse analysis of teachers' messages in official and unofficial WhatsApp groups
Authors: Hussein Suzan Farouq F. , Rashid Radzuwan Ab , Azizan Mazlin , Alali Omar Mohammad Mousa
Published: January 2023

This study explores Jordanian English language teachers' social and discursive practices online. It aims to scrutinize the way Jordanian English language teachers at one of universities in Jordan construct their posts in official and unofficial WhatsApp groups. Employing an ethnographic approach, this paper examines the differences in teachers' discursive behavior in official and unofficial WhatsApp groups. Data generation took place from March 2018 to May 2018. The data were obtained from participants' observation in both official and unofficial WhatsApp groups. 18 English language teachers participated in this study. A total of 817 posts were made throughout the observation period which were included in the analysis. Data generated through participant observations were analyzed using discourse analysis combined with discursive psychology approach. The findings suggest that teachers behave differently in how they talk to their superiors than in how they speak to their colleagues to construct their desired identities. They convey a positive impression to their leaders, and they tend to use persuasive techniques to appear more friendly to others. Exemplification, ingratiation and self-promotion were the impression management techniques used by the participants. This paper concludes that Jordanian English language teachers convey a positive impression to their superiors as they do not want to jeopardize their careers.
Analysis of the anatomic eligibility for transcarotid artery revascularization in Chinese patients who underwent carotid endarterectomy and transfemoral carotid artery stenting
Authors: Fan Weijian , Shi Weihao , Lu Shuangshuang , Guo Wencheng , Tong Jindong , Tan Jinyun , Yu Bo
Published: January 2023

Objective

Transcarotid artery revascularization (TCAR) is thought to be a promising technique and instrument for treating carotid stenosis with favorable outcomes. Since there remain several differences in anatomic characteristics among races, this study was conducted to investigate the anatomic eligibility of TCAR in Chinese patients who underwent carotid revascularization.

Methods

A retrospective review of patients with carotid stenosis from 2019 to 2021 was conducted. The anatomic eligibility of TCAR was based on the instruction of the ENROUTE Transcarotid Neuroprotection System. The carotid artery characteristics and configuration of the circle of Willis (CoW) were evaluated by CT angiography. The demographic and clinical characteristics and procedure-related complications were recorded. Logistic regression was used to analyze the independent factors for TCAR eligibility.

Results

Of 289 consecutive patients [222 for carotid endarterectomy (CEA) and 67 for transfemoral carotid artery stenting (TF-CAS)] identified, a total of 215 patients (74.4%) met TCAR anatomic eligibility. Specifically, 83.7% had mild common carotid artery (CCA) puncture site plaque, 95.2% had 4–9 mm internal carotid artery diameters, 95.8% had >6 mm CCA diameter, and 98.3% had >5 cm clavicle to carotid bifurcation distance. Those who were female (OR, 5.967; 95% CI: 2.545–13.987; P < 0.001), were of an older age (OR, 1.226; 95% CI: 1.157–1.299; P < 0.001), and higher body mass index (OR, 1.462; 95% CI: 1.260–1.697; P < 0.001) were prone to be associated with TCAR ineligibility. In addition, 71 patients with TCAR eligibility (33.0%) were found to combine with incomplete CoW. A high risk for CEA was found in 29 patients (17.3%) with TCAR eligibility, and a high risk for TF-CAS was noted in nine patients (19.1%) with TCAR eligibility. Overall, cranial nerve injury (CNI) was found in 22 patients after CEA, while 19 of them (11.3%) met TCAR eligibility.

Conclusion

A significant proportion of Chinese patients meet the anatomic criteria of TCAR, making TCAR a feasible treatment option in China. Anatomic and some demographic factors play key roles in TCAR eligibility. Further analysis indicates a potential reduction of procedure-related complications in patients with high-risk carotid stenosis under the TCAR procedure.
Immune-related potential biomarkers and therapeutic targets in coronary artery disease
Authors: Liu Chaosheng , Liu Jifeng , Zhang Yunshu , Wang Xi , Guan Yue
Published: January 2023

Background

Coronary artery disease (CAD) is a complex illness with unknown pathophysiology. Peripheral biomarkers are a non-invasive method required to track the onset and progression of CAD and have unbeatable benefits in terms of early identification, prognostic assessment, and categorization of the diagnosis. This study aimed to identify and validate the diagnostic and therapeutic potential of differentially expressed immune-related genes (DE-IRGs) in CAD, which will aid in improving our knowledge on the etiology of CAD and in forming genetic predictions.

Methods

First, we searched coronary heart disease in the Gene Expression Omnibus (GEO) database and identified GSE20680 (CAD = 87, Normal = 52) as the trial set and GSE20681 (CAD = 99, Normal = 99) as the validation set. Functional enrichment analysis using protein-protein interactions (PPIs), Gene Ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) was carried out on the identified differentially expressed genes. Optimal feature genes (OFGs) were generated using the support vector machine recursive feature elimination algorithm and the least absolute shrinkage and selection operator (LASSO) algorithm. Furthermore, immune infiltration in CAD patients and healthy controls was compared using CIBERSORT, and the relationship between immune cells and OFGs was examined. In addition, we constructed potential targeted drugs for this model through the Drug-Gene Interaction database (DGIdb) database. Finally, we verify the expression of S100A8-dominated OFGs in the GSE20681 dataset to confirm the universality of our study.

Results

We identified the ten best OFGs for CAD from the DE-IRGs. Functional enrichment analysis showed that these marker genes are crucial for receptor-ligand activity, signaling receptor activator activity, and positive control of the response to stimuli from the outside world. Additionally, CIBERSORT revealed that S100A8 could be connected to alterations in the immune microenvironment in CAD patients. Furthermore, with the help of DGIdb and Cytoscape, a total of 64 medicines that target five marker genes were subsequently discovered. Finally, we verified the expression of the OFGs genes in the GSE20681 dataset between CAD patients and normal patients and found that there was also a significant difference in the expression of S100A8.

Conclusion

We created a 10-gene immune-related prognostic model for CAD and confirmed its validity. The model can identify potential biomarkers for CAD prediction and more accurately gauge the progression of the disease.
Early cretaceous ridge subduction in the Shandong Peninsula, Eastern China, indicated by Laoshan A-type granite
Authors: Li Jie , Li He , Li Congying , Song Mingchun , Jiang Mengyao , Yuan Shuai , Zhang Lipeng
Published: January 2023

Early Cretaceous A-type granites are widespread in the Shandong Peninsula, which can be used to elucidate the tectonic evolution of the eastern China and the destruction of the North China Craton. However, their genesis is still controversial. Several competing models, ranging from slab break-off, postorogenic extension, foundering of the lower crust and ridge subduction, were proposed. Here, we report zircon U–Pb ages, whole-rock and apatite geochemical compositions of the Laoshan granite and discuss its tectonic implications. The Laoshan granite has typical characteristics of A-type granite with high FeOT/(FeOT + MgO) ratios (0.90–0.97) and 10000*Ga/Al ratios (2.70–3.36) and high total alkali (Na2O + K2O: 7.95–8.70 wt%) contents and Zr+Nb+Ce+Y (most >350 ppm) concentrations. The Laoshan granite is further classified as A1-type based on the Yb/Ta-Y/Nb and Ce/Nb-Y/Nb diagrams and the Nb-Y-3Ga and Nb-Y-Ce triangular discriminant diagrams. Zircon U–Pb dating of two Laoshan granite samples yielded emplacement ages of 117.8 ± 1.0 Ma and 120.1 ± 1.3 Ma, respectively. The oxygen fugacity of the Laoshan granite magma is low, as indicated by zircon Ce4+/Ce3+ ratios (most <300). The crystallization temperature of zircon varies significantly, ranging from 652 to 830°C. The apatite compositions show that the Laoshan granite has high F (2.09–2.72 wt%) and low Cl (0.01–0.09 wt%) contents, consistent with influence by fluid released from the decomposition of phengite. Apatite rare earth elements show that mantle sources are also involved in Laoshan A-type granite. Combined previous studies of A-type granitic plutons in the Shandong Province and the Lower Yangtze River belt with the drifting history of the Pacific plate, we propose that the flat subduction of the spreading ridge between the Pacific and the Izanagi plates was responsible for the formation of Laoshan A-type granite.
Analysis of fault characteristics and oil and gas enrichment differences in the No. 2 structural belt, Nanpu Sag, Bohai Bay Basin, East China
Authors: Zou Juan , Liu Guoyong , Ma Qian , Yu Fusheng , Meng Lingjian , Tian Bo
Published: January 2023

There are great differences in oil and gas enrichment at different locations in petroliferous basins, and faults are an important factor affecting the differential enrichment of oil and gas. In this paper, taking the No. 2 structure in the Nanpu Sag, Bohai Bay Basin, East China, as an example, based on the analysis of fault geometry and kinematics characteristics, the determination of oil source faults, the analysis of fault trap origin and effectiveness, and the analysis of fault caprock combinations are carried out to study the differences and mechanisms of oil and gas enrichment east and west of the Nanpu No. 2 structure. The results show that the fault-source contact relationship affects the direction of oil and gas migration. The No. 2 structure in the Nanpu Sag has a dual-source hydrocarbon supply. The western structure supplies hydrocarbons from the north and east, with oil and gas migrating along the direction parallel and perpendicular to the fault strike. The east structure supplies hydrocarbons from the south and north, with oil and gas migrating along the direction perpendicular to the fault strike. The effectiveness of fault traps affects the scale of oil and gas accumulation. Most of the traps of the Nanpu No. 2 structure formed before hydrocarbon expulsion, which are all effective traps and are conducive to oil and gas accumulation. The relationship between fault and caprock determines the vertical accumulation layers of oil and gas: The faulted thickness of the east structure is large, the fault is vertically closed, and oil and gas are enriched mainly in the deep layer. The faulted thickness of the west structure is small, and oil and gas are enriched in both deep and shallow layers.
The influence of gold mining wastes on the migration-transformation behavior and health risks of arsenic in the surrounding soil of mined-area
Authors: Chen Yu , Liu Guijian , Zhou Chuncai , Zhou Huihui , Wei Yong , Liu Yuan
Published: January 2023

Understanding the characteristic heavy metals and their migration-transformation behavior in mining areas is essential for the prevention and control of mining pollution. This study selected a gold mine in the Anqing-Guichi ore-cluster region in the Middle-Lower Yangtze metallogenic belt as the research area, the concentrations, and migration-transformation mechanisms of metalloid As and typical heavy metals (Cd, Zn, Pb, Cu, Cr, and Ni) in gold mining wastes (mine tailings and sewage sludge) and the surrounding soil (farmland soil and soil a mining area) were investigated. The results showed that the concentration of As was high in both mining wastes and soils, and the geo-accumulation index values of As in soils ranging from 1.44–6.70, indicated that As pollution was severe in the soil. Besides, a close correlation between the concentration of As and the content of iron was observed by XRF analysis, in conjunction with SEM observations, most As-bearing phases are embedded in Fe, O, and Si compounds. According to EDS and XPS results, the Fe-O-As particle was suggested to be Fe-(oxy)hydroxides with absorbed or co-precipitated As. Furthermore, the arsenic phase observed in the soils were consistent with the weathering oxidation products in the tailings, demonstrating that the mineral particles in the tailings could migrate into soils via atmospheric transport, rainwater leaching, surface runoff, etc., and consequently result in heavy metal accumulation. The sequential chemical extraction result showed that the residual state of As in the soil exceeded 60%, and As posed no risk to low risk according to the Risk assessment code result. However, due to the high concentration and high mobility of arsenic, its environmental impact cannot be ignored even if its bio-accessibility in mined area soil is low.
Mechanical response and parametric analysis of a deep excavation structure overlying an existing subway station: A case study of the Beijing subway station expansion
Authors: Han Jianyong , Wang Jun , Cheng Cheng , Zhang Chaozhe , Liang Erbin , Wang Zhikang , Song Jae-Joon , Leem Junsu
Published: January 2023

The existing Beijing Pingguoyuan Subway Station was extended through a extension project. The excavation for the extension was located directly above the existing station. Complex interactions exist between the existing structure and the retaining pile wall of the excavation. Based on this project, three-dimensional finite element models were established to investigate the mechanical characteristics of the embedded and non-embedded retaining pile walls. A parametric analysis was performed for both types of pile walls. The stress and deformation characteristics of the retaining pile walls and existing structures were analyzed. The results show that when the bottom of the non-embedded retaining pile walls are connected to the existing structure, the uplift of the existing structure is essentially constant; however, the maximum displacement of the pile is increased by approximately 2.7 times, and the bending moment of the pile is reduced to 57.1% of the connection condition. As the distance between the embedded retaining pile wall and the existing station increases, the uplift of the existing station increases linearly, whereas the soil between the pile and the station exhibits a non-linear increasing trend. The displacement of the embedded retaining pile wall increases as the inner force decreases. When the distance is greater than 4.7 m, the displacement and force of the pile remains essentially unchanged. The effect of the pile embedded depth on the force and deformation of the pile is mainly observed in the lower part of the pile. As the embedded depth increases, the maximum displacement decreases by approximately 16.9%, the maximum bending moment decreases, and the maximum negative bending moment increases. The key contribution of this research is to provide a prediction method for the mechanical behaviors of a expansion project. The findings from the study also provide industry practitioners with a comprehensive guide regarding the specific applications of the construction technology of a deep excavation structure overlying an existing subway station.
Geochemical reactions altering the mineralogical and multiscale pore characteristics of uranium-bearing reservoirs during CO2 + O2in situ leaching
Authors: Zhou Xingyu , Wang Wei , Niu Qinghe , Wang Qizhi , Su Xuebin , Zhou Genmao , Zhao Lixin , Ji Zhongmin , Qi Xiaofei , Tian Lanlan , Zhang Jianhui , Sun Beibei
Published: January 2023

CO2 + O2in situ leaching has been extensively applied in uranium recovery in sandstone-type uranium deposits of China. The geochemical processes impact and constrain the leaching reaction and leaching solution migration; thus, it is necessary to study the CO2 + O2–water–rock geochemical reaction process and its influence on the physical properties of uranium-bearing reservoirs. In this work, a CO2 + O2–water–rock geochemical reaction simulation experiment was carried out, and the mineralogical and multiscale pore characteristics of typical samples before and after this simulation experiment were compared by X-ray diffraction and high-pressure mercury intrusion porosimetry (HPMIP). The results show that the CO2 + O2–water–rock geochemical reaction has complicated effects on the mineral compositions due to the various reaction modes and types. After the CO2 + O2–water–rock geochemical reaction, the femic minerals decrease and the clay minerals in the coarse sandstone, medium sandstone, fine sandstone, and siltstone increase, while the femic minerals and clay minerals in sandy mudstone show a contrary changing trend. The CO2 + O2–water–rock geochemical reaction decreases the total pore volume of uranium-bearing reservoirs and then promotes pore transformation from small scale to large scale. The fractal dimensions of macropores are decreased, and the fractal dimensions of mesopores, transition pores, and micropores are increased. The effects of felsic mineral and carbonate dissolution, secondary mineral precipitate, clay mineral swelling, and mineral particle migration are simultaneously present in the CO2 + O2in situ leaching process, which exhibit the positive transformation and the negative transformation for the uranium-bearing reservoirs. The mineral dissolution may improve reservoir permeability to a certain degree, while the siltation effect will gradually reveal with the extension of CO2 + O2in situ leaching. This research will provide a deep understanding of the physical property response of uranium-bearing reservoirs during CO2 + O2in situ leaching and indicate the direction for the efficient recovery of uranium resources.
Key predisposing factors and susceptibility assessment of landslides along the Yunnan–Tibet traffic corridor, Tibetan plateau: Comparison with the LR, RF, NB, and MLP techniques
Authors: Wang Sen , Ling Sixiang , Wu Xiyong , Wen Hong , Huang Junpeng , Wang Feng , Sun Chunwei
Published: January 2023

The Yunnan–Tibet traffic corridor runs through the Three Rivers Region, southeastern Tibetan Plateau, which is characterized by high-relief topography and active tectonics, with favourable conditions for landslides. It is of great significance to identify the key predisposing factors of landslides and to reveal the landslide susceptibility in this area. A total of 2,308 landslides were identified as learning samples through remote sensing interpretation and detailed field surveys, and four machine learning algorithms involving logistic regression (LR), random forest (RF), naïve Bayes (NB) and multilayer perceptron (MLP) were compared to model the landslide susceptibility. Through the multicollinearity test, 13 influential factors were selected as conditioning factors. The area under the curve (AUC) values of LR, RF, NB and MLP models are .788, .918, .785 and .836 respectively, indicating that the four models have good or very good prediction accuracy in landslide susceptibility assessment along the Yunnan–Tibet traffic corridor. In addition, the elevation, slope, rainfall, distance to rivers, and aspect play a major role in landslide development in the study area. The susceptibility zoning map based on the best RF model shows that the areas with high susceptibility and very high susceptibility account for 12.24% and 6.72%, respectively, and are mainly distributed along the Jinsha River, the Lancang River and the G214 highway.
The bleaching limits of IRSL signals at various stimulation temperatures and their potential inference of the pre-burial light exposure duration
Authors: Zhang Jingran , Guralnik Benny , Tsukamoto Sumiko , Ankjærgaard Christina , Reimann Tony
Published: January 2023

Infrared Stimulated Luminescence (IRSL) techniques are being increasingly used for dating sedimentary feldspars in the middle to late Quaternary. By employing several subsequent stimulations at increasing temperatures, a series of post-IR IRSL (pIRIR) signals with different characteristics (stability and bleachability) can be obtained for an individual sample. It has been experimentally demonstrated that higher-temperature pIRIR signals are more stable, but they tend to exhibit larger residual doses up to few tens of Gy, potentially causing severe age overestimation in young samples. In this study we conducted comprehensive bleaching experiments of IRSL and pIRIR signals using a loess sample from China, and demonstrated that non-bleachable components in the IR (and possibly pIRIR) signals do exist. The level of such non-bleachable signal shows clearly positive correlation with preheat/stimulation temperature, which further supports the notion that lower temperature pIRIR are advantageous to date young samples and sediments especially from difficult-to-bleach environments. These results display a potential in constrain the pre-burial light exposure history of sediment utilizing multiple feldspar post-IR IRSL (pIRIR) signals. For the studied loess sample, we infer that prior to its last burial, the sample has received an equivalent of >264 h exposure to the SOL2 simulator (more than 2,000 h of natural daylight).
Psychometric properties and invariance of the self-efficacy for writing scale in Peruvian high school students
Authors: León-Gutiérrez Matilde , Morales-García Wilter C. , Morales-García Mardel , Jaimes-Soncco Jania , Saintila Jacksaint , Mamani Percy G. Ruiz
Published: January 2023

Introduction

Being able to write is a key competency in educational models; therefore, it is important to have a scale to assess writing self-efficacy.

Objective

The study evaluated the internal structure, providing evidence of reliability, validity, and factorial invariance of the self-efficacy for writing scale (SEWS) across sex and age in Peruvian schoolchildren.

Methods

An instrumental study was carried out on 1,107 Peruvian adolescents (early, middle, and late) of school age. A confirmatory factor analysis was carried out and the factorial invariance for sex and age was evaluated.

Results

A good fit was obtained for the total sample (χ2= 1229.08, df = 101, CFI = 0.997, TLI = 0.997, RMSEA = 0.057 [90% CI: 0.0540.059], and SRMR = 0.029) and presented good α, ω, and H reliability (>0.89). Correlations between another measure of writing self-efficacy (p =0.76;p< .01), study satisfaction (p= 0.31;p< .01), and burnout (p= −0.12;p< .01) scales supported convergent and concurrent validity. Multigroup factor analysis supported strict invariance for sex and age, for which the SEWS provides evidence of validity and reliability.

Discussion

This adaptation of the SEWS is a valid, reliable, and invariant measure that can be considered for assessing self-efficacy for writing in Peruvian high school students.
Categorization of differences of sex development among Egyptian children and the role of antimullerian hormone and inhibin B
Authors: Abdelghaffar Shereen , AbdelMoneam Engy Nasr , Hassanein Samah A. , Radwan Noha Abdelhalim , Mira Marwa Farouk
Published: January 2023

Background

Differences of sex development (DSD) are congenital conditions linked to atypical development of chromosomal, gonadal, or anatomical sex.

Objective

The aim of this study was to demonstrate our experiences at the Diabetes Endocrine and Metabolism Pediatric Unit (DEMPU), Faculty of Medicine, Cairo University in the field of DSD by focusing on the clinical presentation, laboratory profile, classification, and etiological diagnosis of these conditions. In addition, the present study intended to delineate the importance of serum anti-Müllerian hormone (AMH) and inhibin B in detecting the presence of functioning testicular tissue.

Methods

This cohort study included 451 infants and children with various clinical presentations of DSD. The study performed a retrospective analysis on medical records of established DSD cases to evaluate the clinical importance of AMH and inhibin B. In addition, newly diagnosed patients were prospectively analyzed.

Results

Three hundred thirty-six (74.5%) patients were 46,XY DSD, 98 (21.7%) were 46,XX DSD, 14 patients had other karyotypes and 3 had missing karyotypes. Among the 46XY DSD patients, the most common cause was partial androgen insensitivity. In contrast, congenital adrenal hyperplasia constituted the most common diagnosis in 46,XX DSD cases. The cut off value of serum AMH was 14.5 ng/ml with 100% sensitivity and 55.1% specificity.

Conclusion

Partial androgen insensitivity was the most important cause of 46,XY DSD in Egyptian children, and congenital adrenal hyperplasia was the most common cause of 46,XX DSD. AMH was valuable in detecting functioning testicular tissue.