bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasonic Investigation of Molecular Interactions in Novel Polymer Dextran and Aqueous Urea Solutions
Authors: Panda Subhraraj
Published: January 2025

Aim:

The purpose of this study was to investigate the molecular interactions between
urea and dextran.

Background:

The molecular interaction was examined using an ultrasonic method.

Objective:

The objective of the study was to use measurable data such as density, viscosity, and
ultrasonic velocity to determine the thermoacoustical parameters. The kind and intensity of polymer
molecular interactions as a function of temperature and concentration at various frequencies have
been extensively assessed using the ultrasonic approach. The viscosity (η), density (d), and ultrasonic
speed (U) of polymer dextran and aqueous 6(M) urea were measured throughout a temperature
range of 303 K to 323 K at 5 K intervals.

Method:

A specific gravity bottle, an Ostwald viscometer, and an ultrasonic interferometer were
used to determine the density, viscosity, and ultrasonic velocity, respectively.

Results:

The obtained thermo acoustic parameter suggests the presence of a molecular interaction
in the investigated solution.

Conclusion:

Solute-solvent interactions make up the bulk of interactions. The dynamics of molecular
interactions change with frequency, resulting in less favorable and less efficient interactions at
higher frequencies.

Others:

The analysis revealed that changes in frequency and temperature produce specific differences
in acoustic parameters.
Distribution, Development, Stabilizer, and Consumers Areas of Livestock and Forages-Based Crops; An Emperical Status of Bordered Keerom Regency, West New Guinea-Indonesia
Authors: Mulyadi Mulyadi , Gusbager Piter , Sagrim Meky , Runtuboi Yubelince Yustencin , Iyai Deny Anjelus , Inriani Noveling , Baaka Alnita , Pakage Stepanus
Published: January 2025

Distribution, development, stabilizer, and consumer areas status of livestock development become the objective of this research. Little is known concerning the portrait of livestock production in the neighborhood region of Indonesia and Papua New Guinea such as Keerom Regency in Papua Province. The descriptive method employed was using desk study. The measured parameters were population structure, carrying capacity, regional development, and suitability commodity using LQ. The finding shows that Skanto and Arso Timur hold the first two districts with a high population of the goat. The 2 districts out of 11 districts have no swine recorded. The Skanto District has the highest cattle population recorded, i.e. 4136,38 AU, followed by Arso Timur, Arso, and Arso Barat. Production of fodder from crop yields is harvested from Senggi and Arso, followed by Skanto, Web, Arso Barat, Yaffi, and Arso Timur. Corn is the highest production of crops. Senggi can be a central of livestock development, followed by Arso, Skanto, Web, and Arso Barat. The KPPTR calculation for Keerom regency shows Web district has the highest value of 379.31 ST, while the lowest is Skanto. The goat sector from the point of agribusiness density shows optimum values reached by the Skanto district. The cattle sector from the point of regional density is dominantly shown by Arso Barat. The cattle sector from the point of economic density is dominantly shown by the Skanto district. The criterion found commonly is very dense compared to dense, medium, and rare. The total values of this finding range from 6 to 12 for EU, EW, and UW. In the EU, the WK (CA) of the three commodities is greater found, i.e. 18 areas compared to WPP (DDA) only found 13 areas. The figures for cattle are under 0,50, not achieving 1,00 and greater than that of 1,00. Only in the Skanto district, the LQ mark of the goat reached 0,539. However, swine is the common livestock raised by farmers in Keerom Regency.
Actitudes de Profesores y Estudiantes de Universidades y Escuelas Superiores de Portugal hacia las Personas con Discapacidad
Authors: Nunes Fernandes Maria Lurdes , Calvo Isabel
Published: January 2025

Las actitudes destacan de entre los diversos factores favorables a la inclusión de las personas con discapacidad. Este trabajo ha tenido como objetivos: adaptar y determinar la validez de una escala de actitudes hacia la discapacidad; conocer cómo son las actitudes de profesores y alumnado de escuelas superiores y universidades de Portugal hacia las personas con discapacidad, para ello se utilizó la Escala de Actitudes (EAPD) forma G; conocer si las actitudes cambian según las variables independientes: edad, sexo, ... y proponer cambios y mejoras para la inclusión. La escala EAPD presentó un alto nivel de fiabilidad (estabilidad y consistencia interna). El Alfa de Cronbach obtenido en la muestra piloto (n=100) fue .86, en la muestra de alumnos (n=454) fue .92 y en la muestra de profesores (n=123) .93. Se clasificaron las actitudes en actitudes positivas, neutras y negativas: las actitudes positivas se puntuaron en el intervalo [1,2]; las actitudes neutras en el intervalo ]2, 4[ y las actitudes negativas en el intervalo [4,6]. Los resultados señalan que en contextos universitarios existen actitudes positivas, sin embargo, existe una presencia de actitudes neutras y negativas, importante.
A framework for digital transformation to bridge the education gap during COVID-19
Authors:   Applied College, Shaqra University, Shaqra, 11961, Saudi Arabia, Alsulami Majid H.
Published: January 2025

The COVID-19 pandemic has disrupted education systems worldwide, creating significant challenges for both students and teachers. As schools have been closed, remote learning has become a widely adopted approach. This situation highlights an urgent need to address the education gap caused by the crisis. This study proposes a new framework, referred to as the Digital Transformation Framework to Bridge the Education Gap (DTFBEG), developed using the design science method. The framework includes six main components: online platforms, learning management systems, content creation, interactive tools, remote assessment, and parental involvement. The proposed framework offers promising solutions to the challenges faced by education systems during this critical period. Digital transformation plays a crucial role in maintaining the continuity of education, improving learning experiences, fostering collaboration and communication, and supporting personalized learning. The findings indicate that digital transformation contributes to bridging the education gap by increasing flexibility in the education system and facilitating the acquisition of technical and educational skills.
On the Relation between Overwater Friction Velocity and the Wind Speed During Tropical Cyclones
Authors: Hsu Shih-Ang
Published: January 2025

In the realm of marine meteorology, physical oceanography, and coastal and ocean engineering, the wind-stress across the air-sea interface plays a dominant role. However, under tropical cyclone conditions, there is no consensus for the formulation of the drag coefficient, Cd, in the literature. Based on the wind-gust method and the measurements from data buoy 42001 during Hurricane Lili, it is demonstrated that, U* = 0.073U10 - 0.44, which is valid up to wind speed 47 m s-1 and wind gust to 66 m s-1, here U* is the friction velocity and U10 is the wind speed at 10-m height. This formula is also supported by the atmospheric vorticity method. Applications for this proposed formula to estimate the variation of the wind speed with height and to determine the wind-stress storm surge or saltwater flooding during the most recent Hurricane Helene in 2024 are successful. In addition, it is found that Cd = (1.29Ln(Hs) + 0.27)/1000, which may be used to explain the behavior of the variation of Cd with the significant wave height, Hs. In order to further substantiate the proposed formula, more datasets during other tropical cyclones are incorporated for the validation.
A Mobile App–Based Gratitude Intervention’s Effect on Mental Well-Being in University Students: Randomized Controlled Trial
Authors: Fuller Chloë , Marin-Dragu Silvia , Iyer Ravishankar Subramani , Meier Sandra Melanie
Published: January 2025

Background

Gratitude interventions are used to cultivate a sense of gratitude for life and others. There have been mixed results of the efficacy of gratitude interventions’ effect on psychological well-being with a variety of populations and methodologies.

Objectives

The objective of our study was to test the effectiveness of a gratitude intervention smartphone app on university students’ psychological well-being.

Methods

We used a randomized experimental design to test our objective. Participants were recruited undergraduate students from a web-based university study recruitment system. Participants completed 90 web-based survey questions on their emotional well-being and personality traits at the beginning and end of the 3-week research period. Their depression, anxiety, and stress levels were measured with the Depression, Anxiety, and Stress Scale (DASS-21). After the baseline survey, participants were randomly assigned to either the control or the intervention. Participants in the intervention group used both a fully automated mobile sensing app and a gratitude intervention mobile iOS smartphone app designed for youth users and based on previous gratitude interventions and exercises. The gratitude intervention app prompted users to complete daily gratitude exercises on the app including a gratitude journal, a gratitude photo book, an imagine exercise, a speech exercise, and meditation. Participants in the control group used only the mobile sensing app, which passively collected smartphone sensory data on mobility, screen time, sleep, and social interactions.

Results

A total of 120 participants met the inclusion criteria, and 27 were lost to follow-up for a total of 41 participants in the intervention group and 52 in the control group providing complete data. Based on clinical cutoffs from the baseline assessment, 56 out of 120 participants were identified as being in a subsample with at least moderate baseline symptomatology. Participants in the subsample with at least moderate baseline symptomatology reported significantly lower symptoms of depression, anxiety, and stress postintervention (Cohen d=−0.68; P=.04) but not in the full sample with low baseline symptomatology (Cohen d=0.16; P=.46). The number of times the app was accessed was not correlated with changes in either the subsample (r=0.01; P=.98) or the full sample (r=−0.04; P=.79).

Conclusions

University students experiencing moderate to severe distress can benefit from a gratitude intervention smartphone app to improve symptoms of depression, anxiety, and stress. The number of times the gratitude intervention app was used is not related to well-being outcomes. Clinicians could look at incorporating gratitude apps with other mental health treatments or for those waitlisted as a cost-effective and minimally guided option for university students experiencing psychological distress.
Scientific geovisualization of the dynamics of Sargassum dispersion and landfall in the Caribbean, based on satellite imagery and numerical forecasts.
Authors: Osorno-Covarrubias Francisco Javier , Prado Molina Jorge , Gómez-Rodríguez Gabriela , Mendoza Uriel , Couturier Stéphane
Published: January 2025

This study focuses on the spatial and temporal representation of Sargassum dispersal and landfall dynamics. An automated prototype is developed incorporating the following components: 1) Detection of Sargassum Rafts: Individual sargassum rafts are identified using Sentinel-2 images with a revisiting period of five days. 2) Forecasting/Hindcasting Vector Fields: One-week forecasts (or hindcasts) are obtained at hourly intervals for the primary forces affecting raft movement—currents, tides, waves, and wind—using supercomputing services (Copernicus Marine Service) 3) Lagrangian Simulation: The movement of detected rafts in step 1 is simulated using the vector fields obtained in step 2. For statistical purposes, rafts that land or drift outside the simulation range are logged with details of location, date, and time. 4) Animation Generation: Four animations are produced to visualize: a) Rafts movement, b) Rafts trajectories, c) The dynamics of surface forcings (currents, tides, and waves), and d) The dynamics of above-surface factors (i.e. wind drag, modeled as a percentage of wind speed). 5) Interactive 3D Visualization: All elements are integrated into an interactive globe featuring 3D bathymetry, allowing users to explore sargassum dispersion and landfall predictions (or hindcasts) for specific satellite observation dates.
While the prototype shown takes into account all elements of a monitoring system, it should not be considered as an operational early warning system. Further steps, beyond the scope of this study, would be required, including optimization of the remote sensing technique, improvement of the transport simulation methods, and an experimental framework for accuracy assessment. In this study, we present the interactive geovisualization and discuss its potential for improving the scientific understanding of Sargassum dispersal and landfall patterns, as well as its potential for the implementation of coastal management policies.
A comparison is made with existing systems, highlighting the limitations and advantages of our approach while discussing its potential for developing a robust Sargassum monitoring and early warning system for the Caribbean Sea.
Nanotechnology in Cancer Therapy: A Paradigm Shift in Oncology
Authors: Sayyad Arman
Published: January 2025

The application of nanotechnology in cancer therapy has revolutionized oncology by enabling precise, targeted, and
minimally invasive treatment modalities. Nanoparticles, with their unique physicochemical properties, have emerged as versatile
tools for improving drug delivery, imaging, and therapeutic efficacy. This review explores the role of nanotechnology in
overcoming traditional challenges in cancer treatment, such as systemic toxicity, poor bioavailability, and resistance to
chemotherapy. Key advancements include the development of multifunctional nanoparticles capable of simultaneous drug
delivery and diagnostic imaging, as well as nanoscale systems designed to bypass biological barriers and deliver therapeutics
directly to tumor sites. Additionally, nanotechnology has paved the way for innovative approaches like photothermal and
photodynamic therapies, which harness light-mediated mechanisms to eradicate cancer cells with minimal damage to healthy
tissues. Despite these advancements, challenges such as nanoparticle biocompatibility, scalability, and regulatory approval
remain critical hurdles to widespread clinical adoption. This review provides a comprehensive overview of the current state of
nanotechnology in cancer therapy, highlights its transformative potential, and discusses future directions for research and
clinical translation. By bridging the gap between engineering and medicine, nanotechnology promises to redefine cancer care
and improve patient outcomes
Experimental Study of Conventional and Self-Healing Concrete
Authors: Jatav Sonu
Published: January 2025

The service life of concrete structures exposed to the environment has diminished in the modern construction sector
due to their low strength, durability, and other features. One special technique for fixing or healing cracks that have formed in
the structures is the bio-mineralization of calcium carbonate with the aid of microbes like Bacillus. This study explains how the
durability of concrete buildings may be improved by including bacterial cells and other nutrients required for the bioremediation process. During calcification, calcium is created when carbonate ions and calcium precipitate released by
microorganisms interact. As a result, the carbonate (calcite) layer cracks mend themselves. According to a study, employing
concrete cubes that have been treated with microorganisms would make concrete constructions more resilient.
Konsep Ekowisata Sebagai Role Model Pengembangan Kawasan Daya Tarik Wisata (DTW) Pada Pengelolaan Subak Perkotaan Denpasar Dalam Perspektif Hukum Kepariwisataan
Authors: Martha Dewa Agung Gede Mahardhika , Mahaputra I B. Gede Agustya , Putra I Made Aditya Mantara
Published: January 2025

Tourism is an essential resource for regions that serve as tourist destinations. Indonesia, rich in culture and tourism, boasts a wide range of tourist sites spread across its provinces. One of Indonesia's premier tourist destinations is Bali, an island known for its unique natural and cultural wealth that attracts visitors from around the world. However, tourism development often conflicts with environmental preservation, such as the lack of attention to subak (traditional irrigation systems) in urban areas. Subak, with its cultural foundations, has the potential to be developed into tourist attractions (DTW). Therefore, the concept of ecotourism is seen as a suitable approach for developing tourism attractions in urban subak areas.This research focuses on the role of ecotourism as a model for developing tourism attractions within urban subak systems and the implications of this model based on tourism law principles in Denpasar. The research employs normative legal methods, using both statutory and conceptual approaches. The expected findings aim to serve as a foundation for formulating policies and strategies to develop ecotourism in Denpasar's urban subak areas. These policies and strategies should be grounded in tourism law principles while addressing aspects that need improvement for effective ecotourism implementation in urban subak areas.
THE ROLE OF ALLULOSE AND SUGAR ALCOHOLS IN GUT MICROBIOTA MODULATION AND METABOLIC HEALTH: A REVIEW
Authors: Eissa Mostafa Essam
Published: January 2025

Allulose and sugar alcohols, like erythritol and xylitol, are low-calorie sweeteners gaining attention for their potential to positively influence metabolic health. This brief review explores how these sweeteners can shape the gut microbiota. Acting as prebiotics, they can foster the growth of beneficial bacteria and stimulate the production of short-chain fatty acids. These effects may contribute to improved insulin sensitivity, reduced inflammation and a stronger gut barrier. However, excessive sugar alcohol intake can lead to digestive discomfort. Further research is needed to assess the long-term impact of these sweeteners on gut microbiota and metabolic health, as well as their interactions with other dietary factors. By understanding the intricate relationship between these sweeteners, gut microbiota and metabolic health, it will be possible to develop well-informed dietary guidelines to optimize health and well-being.
                 
Peer Review History:
Received 5 October 2024;   Reviewed 12 November; Accepted 22 December; Available online 15 January 2025
Academic Editor: Prof. Dr. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com
Average Peer review marks at initial stage: 5.0/10
Average Peer review marks at publication stage: 7.0/10
TRANSFORMING PHARMACY EDUCATION IN UNANI SYSTEM OF MEDICINE: A CRITICAL EVALUATION OF ANCIENT, PRESENT, AND FUTURE
Authors: Amreen  , Saleem Mohd Nauman , Asif Iqbal Siddiqui
Published: January 2025

This review article illuminates; a brief historical outline of the origin, evolution and current scenario of the Unani system of Medicine (USM) and Ilmul Saidla (Pharmacy), major issues in Pharmacy (Unani) education, training, practice, including lacunas in; course, curriculum, research, and innovation. The promising and constructive revolutionary idea of the educational system that should be implemented by the establishment of the Bachelor, Master, Doctor of Pharmacy, and Doctor of Philosophy degrees in Pharmacy (Unani) is also given. The objective of this futuristic vision is to produce skilled pharmaceutical professionals in USM to meet the requirements of Unani pharmaceutical industries, supervision of dispensaries of hospitals, public healthcare services and to upgrade the text and knowledge of Pharmacy (Unani). This paper offers a unique opportunity to spark meaningful discussions, encourage critical reflection, and guide strategic planning, making it an essential resource for the ongoing enhancement of the new Pharmacy education system in USM, to achieve impactful and positive outcomes.
                 
Peer Review History:
Received 10 October 2024;   Reviewed 11 November; Accepted 20 December; Available online 15 January 2025
Academic Editor: Dr. Jennifer Audu-Peter, University of Jos, Nigeria, drambia44@gmail.com
Average Peer review marks at initial stage: 6.0/10
Average Peer review marks at publication stage: 7.0/10
Efficient discrimination between real and complex quantum theories
Authors: Batle Josep , Białecki Tomasz , Rybotycki Tomasz , Tworzydło Jakub , Bednorz Adam
Published: January 2025

We improve the test to show the impossibility of a quantum theory based on real numbers by a larger ratio of complex-to-real bound on a Bell-type parameter. In contrast to previous theoretical and experimental proposals the test requires three settings for the parties A and C, but also six settings for the middle party B, assuming separability of the sources. The bound we found for this symmetric configuration imposed on a real theory is 14.69 while the complex maximum is 18. This large theoretical difference enables us to demonstrate the concomitant experimental violation on IBM quantum computer via a designed quantum network, without resorting to error mitigation, obtaining as a result 15.44 at more than 100 standard deviations above the found real bound.
Triage and Criminal Responsibility
Authors:   Journal of Law research, Choi Dae-Ho
Published: January 2025

In this article, we reexamine the theory of emergency evacuation and conflict of duty under criminal law, taking into account the so-called ‘triage’ situation, with issues related to the distribution of medical resources in mind. Accordingly, the purpose is to reduce the burden of criminal liability on medical personnel when they encounter an emergency situation and to provide a foundation for rapid emergency rescue. The contents are briefly summarized as follows.
In the case of ‘Ex ante-Triage’, since the equivalent duty-the doctor's duty to provide life-saving treatment-​​conflicts with each other according to the legal theory of justifiable conflict of duties, the illegality is eliminated regardless of which duty is chosen. However, in such situations, medical professionals who are faced with decisions may feel a tremendous mental burden, such as anxiety about whether they are treating the disabled at a disadvantage, so it is desirable to establish specific implementation standards and procedures to resolve this. In this case, there is a problem in that it changes the theory of conflict from theory of obligation to utilitarianism based on the likelihood of success in theory of conflict of obligation, which allows for qualitative and quantitative comparisons between life and life. Therefore, from the perspective of equality, the latter contingency principle is still valid. In the case of ‘Ex post-Triage’, the prevailing view is that the problem of conflict between the duty to inaction and the duty to act should be resolved through the application of emergency evacuation regulations rather than the legal doctrine of conflict of justifiable duties. However, even in this case, the Coca-Vila theory is superior in its theoretical composition, which acknowledges that it is a case of conflict of duties, examines the equivalent value of conflict of duties, and then denies justification by conflict of duties.
Since our country has adopted a similar legal system and legal theory to Germany, discussions on triage in Germany will be of great value to our country in many ways. However, there is a need to develop an independent triage theory that is suitable for our country's medical, cultural, and legal systems. In addition, among the multiple life protection obligations, failure to fulfill one of the obligations will inevitably result in a breach of duty. In such extreme situations, it is desirable to legislatively present certain clear criteria to serve as selection guidelines in order to avoid placing excessive legal and mental burdens on doctors.
Even so, there is a need to develop an independent triage theory that is suitable for our country's medical, cultural, and legal systems. In addition, in extreme situations where one party's performance of multiple life protection obligations can immediately lead to a breach of duty, excessive legal and mental burdens should not be placed on doctors. For this purpose, it would be desirable to establish clear criteria that can serve as legislative selection guidelines.
数字经济下医药税收管理问题研究
Authors:   Journal of Law research, He Yanqun
Published: January 2025

In the era of the digital economy, the deep integration of information technology with the pharmaceutical industry has become a new engine for innovation and development in the pharmaceutical sector. However, the integration of the pharmaceutical industry faces a series of challenges, such as difficulties in the identification of tax elements, asymmetry of tax-related information, low levels of informatization in pharmaceutical enterprises, insufficient information technology capabilities in tax authorities, and incomplete policies and regulations in the pharmaceutical industry, which constrain the healthy development of pharmaceutical companies. Against the backdrop of modern tax governance reform, the pharmaceutical industry urgently needs to strengthen tax management to adapt to new changes. Firstly, tax authorities need to leverage information technology to innovate and transform the systems of tax law enforcement, services, and regulation. Secondly, pharmaceutical companies need to use information technology to solidify their management foundations and enhance their capabilities and skills. Lastly, tax laws and policies related to the pharmaceutical industry need to be adjusted and improved in a timely manner to meet the new requirements of the digital transformation in the pharmaceutical sector. With the joint efforts of all parties, support and protection can be provided for the healthy development of the pharmaceutical industry.

在数字经济时代，信息技术与医药产业的深度融合，已成为推动医药行业创新和发展的新引擎。然而，医药产业融合发展过程中面临一系列挑战，税收要素认定困难、涉税信息不对称、医药企业信息化水平不高、税收部门信息化征管能力不足、医药行业政策法规不健全等，制约医药企业健康发展。在税收治理现代化改革背景下，医药行业亟需加强税收管理以适应新变化。首先税务机关需要利用信息技术，实现税务执法、服务、监管制度的创新和变革。其次医药企业需要运用信息化手段，夯实管理基础，提升能力与本领。最后医药税收法规政策需要与时俱进的调整与完善，以适应医药行业数字化转型的新要求。在多方共同努力之下，为医药行业的健康发展提供支持和保障。
健康医疗数据开放的竞争隐忧与中国反垄断应对
Authors:   Journal of Law research, Lei Haonan , Wu Zongze
Published: January 2025

As a policy trend in many jurisdictions around the world, health care data openness can effectively improve the level of public governance, drive innovation in the medical industry, and promote market competition in the medical industry to a certain extent. However, the process of opening up health care data often comes with the risk of competition. First, the opening of health care data may lead to more efficient and stable collusion in reaching and implementing collusion. Second, the opening of health care data will also lead to more exploitative and exclusive abuse in the health care industry. Third, the opening of health care data will also lead to the frequent occurrence of data-driven and leveraged mergers and acquisitions risks. In order to effectively eliminate competition risks, China should propose new anti-monopoly countermeasures. On the one hand, China should strengthen the legislative regulations on the opening of health and medical data, including the regulation concept of monopoly agreement should be adjusted from information transparency to the implementation of classification and classification, and the regulation of abuse of market dominance should pay attention to the quantification of market power and the identification of specific behaviors, so as to include operators' commitments in the regulation of data-driven mergers and acquisitions. On the other hand, China also needs to introduce a full-chain regulatory system that combines the dual effects of competition advocacy and law enforcement, in the form of prior routine market investigations and fair competition reviews, as well as a flexible in-process and after-action regulatory approach. In addition, it is also necessary for China to build a coordinated regulatory model across multiple departments. On the basis of emphasizing the fundamental position of competition policy, we should make full use of the power of social supervision to regulate the restrictive competition behavior in the process of health and medical data opening in a more comprehensive way, and improve the safety and innovation of health and medical data opening to the greatest extent.

健康医疗数据开放作为世界范围内多个司法辖区的政策趋向，能有效提高公共治理水平、驱动医疗行业创新，以及在一定程度上促进医疗行业的市场竞争。然而，健康医疗数据开放过程通常伴随着竞争风险。其一，健康医疗数据开放可能导致共谋的达成与实施更高效，以及共谋合意更加稳定。其二，健康医疗数据开放也会导致医疗行业的剥削性滥用与排他性滥用行为更加普遍。其三，健康医疗数据开放还会导致数据驱动类与杠杆并购类风险的频发。为了有效消除竞争风险，中国应提出新的反垄断应对方案。一方面，中国应强化健康医疗数据开放的立法规制，包括垄断协议规制理念应从调整信息透明度到实施分级分类，滥用市场支配地位的规制则需注重市场力量的量化与具体行为的识别，将经营者承诺前置纳入数据驱动型并购的规制中。另一方面，中国还需要导入全链条监管体系，以结合竞争倡导与执法的双重功效，具体表现为事前常规性市场调查与公平竞争审查双管齐下，以及构建弹性的事中与事后监管方式。此外，构建多部门的协同监管模式对中国而言同样必要。在强调竞争政策的基础地位上，充分借助社会监管的力量，较为全面地规制健康医疗数据开放过程中的限制竞争行为，最大程度提高健康医疗数据开放的安全性与创新性。
Pengaruh Pemberian Edamame Rebus (Glycine Max (L) Merrill) sebagai Camilan Sehat terhadap Penurunan Tekanan Darah Penderita Hipertensi
Authors: Abdul Halif Novi Ramadhanif , Sulistyowati Etik , Kaswari Sutomo Rum Teguh , Mustafa Annasari
Published: January 2025

Diet yang tepat untuk hipertensi yakni melalui pengaturan asupan makanan. Konsumsi makanan yang kaya akan kalium, serat, asam folat, isoflavon, kalsium, dan magnesium mampu menurunkan tekanan darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kacang edamame rebus terhadap penurunan tekanan darah penderita hipertensi di Puskesmas Dinoyo. Hanya 13 dari 24 responden dalam sampel penelitian yang dipilih berdasarkan kriteria inklusi dan eksklusi menggunakan jenis penelitian pre-eksperimental dan rancangan one group pretest-postest. Pengumpulan data dilakukan dengan cara wawancara menggunakan formulir Food Recall 2x24 Jam, penggunaan garam dapur, dan identitas responden. Intervensi dalam penelitian ini adalah memberikan edamame rebus tanpa garam atau penyedap rasa sebanyak 5 porsi dalam 1 minggu (40 gram/hari) hanya sekali makan di waktu selingan. Analisis data menggunakan uji paired sample t test dan uji wilcoxon dengan tingkat signifikansi 95%. Hasil penelitian menunjukkan terjadi peningkatan rerata asupan Na (2131,5 mg), K (1416,8 mg), Ca (231,6 mg), Mg (212,9 mg), dan Serat (10,4 gram) responden setelah diberikan intervensi walaupun masih tergolong kurang serta pemberian edamame rebus memengaruhi penurunan tekanan darah sistolik dan diastolik responden dengan nilai p-value masing-masing 0,025 dan 0,002. Edamame rebus mampu menurunkan tekanan darah yakni dari 159/100 mmHg menjadi 147/87 mmHg. Disarankan untuk menambahkan sampel kontrol dan variasi bentuk atau jenis intervensi berbahan dasar edamame.
Hubungan Asupan Lemak dan Aktivitas Fisik dengan Risiko Sindrom Metabolik pada Remaja SMA Batik 1 Surakarta
Authors: Sukmawati Maya , Sarbini Dwi
Published: January 2025

Sindrom metabolik merupakan kumpulan dari beberapa komponen yang ditandai dengan 5 kriteria (lingkar perut, kadar trigliserida tinggi, glukosa darah meningkat, tekanan darah tinggi,  dan kadar HDL rendah) yang dapat menyebabakan seseorang memiliki risiko mengalami penyakit tidak menular. Hasil studi pendahuluan menunjukkan sebanyak 72% remaja memiliki lingkar perut berlebih. Kejadian sindrom metabolik mengalami peningkatan terutama pada usia remaja dan peningkatan tersebut dapat dikarenakan oleh beberapa faktor seperti konsumsi tinggi lemak dan aktivitas fisik tidak baik. Tujuan; Penelitian ini bertujuan untuk mengetahui hubungan asupan lemak dan aktivitas fisik dengan risiko kejadian sindrom metabolik remaja di SMA Batik 1 Surakarta Tahun 2024. Metode penelitian ini menggunakan desain cross-sectional. Jumlah sampel sebanyak 65 remaja yang dipilih secara proportional random sampling. Kriteria inklusi penelitian ini yaitu remaja sehat secara jasmani, dapat berkomunikasi dengan baik, saat pengambilan data tidak dalam kondisi puasa, tidak melakukan diet tertentu dan tidak mengkonsumsi suplemen peluntur lemak. Instrumen penelitian menggunakan SQ-FFQ untuk mengetahui jumlah asupan lemak yang dikonsumsi selama 1 bulan terakhir. Kuesioner GPAQ untuk mengukur aktivitas fisik responden selama 1 minggu terakhir. Analisis statistik dengan uji chi-square. Hasil penelitian ini yaitu terdapat hubungan antara asupan lemak dengan risiko sindrom metabolik (p value = 0.001) dan aktivitas fisik dengan risiko sindrom metabolik (p value = 0.017). Remaja yang mengkonsumsi lemak berlebih dan aktivitas fisik tidak baik sebagian besar berisiko mengalami sindrom metabolik.
Hubungan Frekuensi Konsumsi Jajanan dan Aktivitas Fisik dengan Status Gizi pada Siswa SMP Muhammadiyah 1 Gatak
Authors: Rahmadani Vira Annisa , Kisnawaty Sudrajah Warajati , Muwakhidah Muwakhidah
Published: January 2025

Permasalahan gizi pada anak remaja terbilang cukup tinggi karena masa ini seseorang akan mengalami masa petumbuhan yang cepat setelah masa bayi dan anak-anak. Permasalahan gizi anak akan banyak terdampak dari jajanan yang dikonsumsi dan banyaknya aktivitas fisik yang dilakukan. Tujuan penelitian ini untuk mengetahui hubungan frekuensi konsumsi jajanan dan aktivitas fisik dengan status gizi pada siswa SMP Muhammadiyah 1 Gatak. Metode yang digunakan dalam penelitian ini adalah Observasional Analitik dengan cross sectional sebagai pendekatannya. Penelitain ini dilakukan di SMP Muhammadiyah 1 Gatak dengan sampel berjumlah sebesar 66 siswa. Pemilihan sampel dilakukan dengan Simple Random Sampling. Pengukuran variabel frekuensi konsumsi jajanan dilakukan dengan form Food Frequency Questionnaire (FFQ) jajanan dalam 1 bulan terakhir, pengukuran aktivitas fisik dilakukan dengan form aktivitas fisik selama 7 hari dengan menghitung nilai PAL, dan pengukuran status gizi dengan indeks IMT/U. Analisis data yang digunakan adalah Uji Korelasi Pearson. Hasil analisis univariat menunjukkan siswa SMP Muhammadiyah 1 Gatak paling banyak memiliki frekuensi konsumsi jajanan yang jarang (53%), aktivitas fisik ringan (50%), dan status gizi baik (72,7%). Hasil analisis bivariat menunjukkan tidak ada hubungan antara frekuensi konsumsi jajanan (p = 0,234) dan aktivitas fisik (p = 0,126) dengan status gizi. Tidak ada hubungan yang signifikan antara frekuensi konsumsi jajanan dan aktivitas fisik dengan status gizi pada siswa SMP Muhammadiyah 1 Gatak.
Kadar Protein dan Tingkat Kekerasan pada Cookies Tepung Gaplek dan Tepung Tempe sebagai Potensi Terapi Celiac Disease
Authors: Nariah Husna , Kisnawaty Sudrajah Warajati , Purwani Eni
Published: January 2025

Penyakit celiac adalah kelainan autoimun komplek dengan manifestasi klinik beragam yang yang tejadi pada individu yang memiliki kecenderungan genetik dan pemicunya adalah konsumsi gluten. Terapi untuk penderita penyakit celiac adalah dengan diet bebas gluten. Cookies dengan menggunakan bahan tepung gaplek dan tepung tempe dipilih sebagai salah satu makanan diet bebas gluten yang berpotensi sebagai terapi penyakit celiac. Tujuan dari penelitian ini adalah untuk mengetahui kadar protein dan tingkat kekerasan cookies tepung gaplek dan tepung tempe. Pada penelitian ini metode yang digunakan adalah rancangan acak lengkap yang terdiri dari 1 kontrol dan 3 perlakuan perbandingan tepung gaplek dan tepung tempe yaitu F1 (kontrol) F2 ( tepung gaplek 25% : tepung tempe 75%) F3 (tepung gaplek 50% :  tepung tempe 50%) F4 (tepung gaplek 75% : tepung tempe 25%). Data kadar protein dan tingkat kekerasan yang diperoleh melalui uji normalitas data dengan menggunakan Saphiro Wilk. Uji kadar protein terdapat data tidak normal (<0,05) dan dilanjutkan dengan uji Kruskal Wallis, kemudian uji Mann Whitney untuk mengetahui perbedaan disetiap perlakuan. Texture Analyzer (hardness, gumminess, fracture, chewiness, cohesiveness, adhesiveness) berdistribusi normal (>0,05) sehingga dilanjutkan dengan uji Anova yang menunjukkan tidak ada perbedaan antar perlakuan pada cookies kecuali pada parameter adhesiveness sehingga dilanjutkan dengan uji Post Hoc. Hasil dari penelitian ini terdapat perbedaan kadar protein cookies dari setiap perlakuan (p<0,05) F1 3,9%; F2 7,95%; F3 6,78%; F4 4,37% dan tidak terdapat perbedaan pada tingkat kekerasan cookies dari setiap perlakuan (p>0,05) F1 36,14%; F2 38,57%; F3 43,85%; F4 43,29%.
Modelling of sanitary wastewater composition and operation of a small membrane bioreactor wastewater treatment plant with denitrification and nitrification
Authors: Mitrinovic David , Perovic Marija , Kovacevic Srdjan , Popovic Miodrag , Radibratovic Zorana
Published: January 2025

The ratio of concentrations of total nitrogen and five-day biochemical oxygen demand in the sanitary wastewater of an energy infrastructure facility in Serbia is many times higher than usual, resulting in only half of the total nitrogen being eliminated in wastewater treatment plants (membrane bioreactor with anoxic and aerobic reactors) by denitrification. The first step of analysis was mathematical modelling of the composition and origins of the input wastewater. The model was developed based on the scientific literature data on composition of human excrement and the data on composition of water used for sanitary purposes. Next, it was successfully verified by comparisons to the experimental data of the wastewater composition. In the next step, a model for wastewater treatment simulation was created by using the BioWin software (Envirosim Associates, USA) in order to examine functioning of the plant and test the effects of several possible modifications of the process. A good agreement with the qualities of the influent and effluent determined by laboratory analyses was achieved after model calibration. The results of simulations showed a tenfold decrease in the total nitrogen concentration and a fortyfold decrease in the total phosphorous concentration in the effluent after introducing the following modifications to the simulated process: ferric chloride dosing, increasing dosing of acetate in the anoxic reactor by a factor of seven, increasing of the waste activated sludge rate by a factor of four and increasing the recirculation flow rate by a factor of three.
An exploratory qualitative assessment of patient and clinician perspectives on patient-reported outcome measures and disease-modifying therapies in adults with spinal muscular atrophy
Authors: Slayter Jeremy , Casey Lauren , McCullum Shane , Drost Dorothy , Banks Allison , O'Connell Colleen
Published: January 2025

Objective: To understand patient, caregiver, and clinician perspectives on patient-reported outcome measures, critical functional domains, and disease-modifying therapies in adult spinal muscular atrophy.
Design: An exploratory qualitative single-site study.
Patients: Ten adults with spinal muscular atrophy and two clinicians participated in semi-structured interviews.
Methods: Semi-structured interviews were conducted virtually or in person with participants after they completed outcome measures at a routine clinic visit. Two researchers analysed transcripts concurrently using a thematic approach to determine themes.
Results: Ten themes were identified among partici-pants. Patient-reported outcome measure preference varied between functional groups and was under-responsive, although it captured meaningful data. Motor stability was most frequently expected with disease-modifying therapy, but participants also reported improved fatigue and respiratory status.
Conclusion: After considering patient goals, functional status, and preferences, patient-reported outcome measures represent a valuable adjunct to standard clinical and research tools. Optimal selection of patient-reported outcome measures requires careful consideration of multiple patient factors. Collaborative development of modified patient-reported outcome measures may yield a responsive, meaningful, and acceptable tool that can be used across a broad functional spectrum.
Los saberes significativos: La secante de la enseñanza y del aprendizaje en la educación
Authors: Burbano Palacios Enyth Fadira
Published: January 2025

La educación actual enfrenta numerosos desafíos, lo que exige una reflexión crítica para transformarla y adaptarla a las formas de aprendizaje de las nuevas generaciones. Las estrategias de enseñanza tradicionales están lejos de alcanzar este objetivo. La brecha entre los saberes recibidos en años anteriores con los que se tienen hoy en día a disposición en varios formatos y espacios, es muy evidente. Los docentes aprendimos bajo una realidad y contexto que difiere a la manera en la que las actuales generaciones absorben conocimiento. El objetivo del presente ensayo es generar una crítica constructiva de la misión de la educación en pleno siglo XXI, haciendo una analogía entre el círculo y la circunferencia, que, en un contexto metafórico, ilustra el contraste entre los modelos educativos tradicionales y la construcción dinámica del conocimiento, siendo el círculo el limitante de la transferencia de conocimientos y la circunferencia la catalizadora de la apropiación, transformación y construcción de saberes. Esta mutación da lugar a la ruptura del arco que encierra al círculo, que lo contiene y por tanto a los constructos que cada individuo va generando en su propio proceso de aprendizaje. Esta ruptura favorece a la transmisión de lo aprendido por medio de la secante que atraviesa dicho círculo, haciendo que la enseñanza valiosa y relevante perdure y trascienda en aprendizajes significativos.
Gegara Promo Malah Ketagihan! Perilaku Repurchase Intenton Pelanggan Belikopi Kota Semarang
Authors: Deo Viandra Agustinus  , Febrianur Ibnu Fitroh Sukono Putra
Published: January 2025

Industri food and beverage yang bertumbuh sangat pesat adalah coffee shop. Persaingan bisnis ini sangat ketat sehingga perusahaan perlu menciptakan produk-produk  yang mengikuti selera konsumen. Coffee Shop yang dimaksud adalah BeliKopi. Penelitian ini memikiki tujuan guna menguji pengaruh customer experiences, brand trust terhadap repurchase intention melalui sales promotions sebagai variabel moderasi pada Belikopi di Kota Semarang (Semarang Tengah). Metode yang digunakan pada penelitian ini yakni purpose sampling menggunakan 103 responden memakai penyebaran kuesioner dengan google from. Dengan proses analisis data menggunakan SmartPLS versi 4. Hasil temuan mengungkapkan yakni customer experiences dan brand trust berpengaruh secara positif signifikan pada repurchase intention, sedangkan customer experience dan brand trust tidak berpengaruh secara positif signifikan pada repurchase intention dimoderasi oleh sales promotion pada Belikopi di Kota Semarang (Semarang Tengah).
The spesies diversity of arthropods in surjan and conventional farming systems in the Special Region of Yogyakarta
Authors: Wagiyana Wagiyana , Alfarisy Fariz Kustiawan , Suharto Suharto , Habriantono Bakhroini , Khozin Mohammad Nur , Suandana Febery Hery
Published: January 2025

An ecosystem is the relationship between insects and the environment in carrying out life processes. The majority of insects are herbivores, and plants serve as their main hosts. Plants also secrete hormone compounds that are favored by arthropods as both a food source and a host for survive. Based on their nature, arthropods are divided into pests and natural enemies. The surjan system is one of the agroecosystem modifications for sustainable agriculture. The study aimed to assess arthropod spesies diversity in different cropping systems. Monitoring was conducted on surjan and conventional land, using several types of traps, including pitfall traps, yellow traps, and pheromone traps. The diversity of arthropods in an ecosystem serves as an indicator of environmental health. This research provides recommendation for managing arthropods, whether as pests or natural enemies. The highest diversity index value was found in the conventional system, with the Shannon_H’ value of of 1.57 for trapping 1, 1.27 for trapping 2, 2.06 for trapping 3, and 1.20 for trapping 4. The species diversity (H’ > 1) value was classified in the medium category. The results of morphological identification revealed two species with the highest abundance: Bactrocera sp. and Atherigona sp. The effectiveness of yellow traps was higher compared to other types of trap, capturing a total of 280 species of pests.
Navigating Islamic Da'wah for Polygamous Family Resilience: Family Communication and the Islamic Mindset
Authors: Rubani Mardhiah , Sazali Hasan , Metia Cut
Published: January 2025

This research examines navigating polygamous family dynamics: family communication and mindset in an Islamic context using a mixed methods explanatory model. Quantitative data from respondents to measure the correlation and influence of family communication, family structure, and religious orientation on the resilience of polygamous families. In contrast, qualitative data from informants were used to analyze navigating polygamous family dynamics: family communication and mindset in an Islamic context which includes communication in building family meaning, relationship maintenance, and problem-solving in polygamous families. The results showed that the resilience of polygamous families can be maintained if family communication, family structure, and religious orientation used are in line with or well accepted by all family members. The calculated F value of 51.331> the F table value of 2.73 and the sig value is 0.01 <0.05 then H0 is rejected and Ha is accepted, meaning that the variables of Family Communication (X1), Family structure (X2), and Religious orientation (X3) affect family resilience (Y). Islamic Da'wah, when applied correctly and contextually, can play an important role in strengthening the resilience of polygamous families by improving effective communication and using the right Islamic mindset.
Analysis of Science Learning Local Context (SeLoC) with Entrepreneurship Orientation for Life-Long Learning of Junior High School Students
Authors: Lipikuni Hilary Fridolin , Henukh Anderias , Benu Rince Sefriana Margarita
Published: January 2025

This study aims to explore how the implementation of Science Learning Local Context (SeLoC) with an entrepreneurial orientation can support the development of lifelong learning (LLL) skills in junior high school students. The study used a descriptive method with a mixed methods approach. This study involved 10 schools in Kupang as well as 20 science teachers and 200 students/ Instruments used included questionnaires, in-depth interviews, and observations. Data were collected through interviews with teachers and students, observations of the implementation of SeLoC in class, and questionnaires to measure student and teacher perceptions. Qualitative data analysis was carried out thematically to identify patterns of student engagement and entrepreneurship integration, while quantitative data were analyzed using descriptive statistics. The results of interviews with teachers showed that SeLoC integration was viewed positively because it was able to improve practical skills and student engagement in science learning. However, the implementation of SeLoC is still limited to extracurricular projects. From the results of student interviews, they felt more interested in science learning that was relevant to everyday life. Observations revealed that SeLoC had not been fully integrated into the formal curriculum. The results of the questionnaire showed the majority of respondents (50%) agreed that SeLoC encourages innovation in learning, 45% agreed that science results can be used for new products, and 50% agreed that SeLoC develops an entrepreneurial and ethical mindset. In lifelong learning skills, 45% of respondents agreed that science learning supports learning continuity and increases adaptation and motivation, and 40% agreed that it supports independent learning. This study recommends further development of the SeLoC curriculum and specific training for teachers.Keywords:science learning, local context, entrepreneurship, life-long learning