bluuebunny/crossref_metadata_2025 huggingface dataset:
Automatic Irrigation System Using Wireless Sensor Network
Authors: Rath Purushottam
Published: June 2022

Abstract: The wireless device network consists of a variety of sensors, computers, and wireless communications. These inventions can be used for controlling the crop parameters within the field. WSN is used as part of agriculture for a variety of reasons such as providing high interpretation, increasing crop production, low energy consumption and widely distributed information. good water management plays an important role in agriculture. Lack of water resources and high number of water pumps relieve management in a very important way. Today, the automatic irrigation system (AIS) is being used to improve the use of agricultural water resources to increase productivity. This irrigation system framework allows for development in a variety of waterless areas. In this way, an effective emergence and irrigation system offers the best advantage in rock bottom water
Literature Review on Design and Fabrication of Agriculture Machine by Using “A. I. S.”
Authors: Ingle Dr. A. H.
Published: June 2022

Abstract: Manual spraying of pesticides and herbicides to crops and weed inhibitors onto the field are quite laborious work to humans. Manual trimming of selected unwanted plants or harvested crops from the field is also difficult. Our project proposes a multipurpose solar powered, flexible, Remote Controlled, semi-automated spraying machine with 4 Degrees of Freedom (DoF) in spatial movement, with an additional plant mowing equipment. The machine is designed to spray pesticide/insecticide directly onto individual lesions minimizing wastage or excess chemical spraying, hence making the system cost effective and also environment friendly. It is designed to cut down undesired plants selectively by remotely controlling the start and stop of the mowing system. Alternatively, it also serves the purpose of maintaining lawns and sports field made of grass. The same system can be used for water spraying and mowing the grass to desired levels, leading to proper maintenance of the field.
Pembangunan Back – End Untuk Meningkatkan Fungsionalitas Buku Sekolah Elektronik (BSE) Tematik 8 Menggunakan Application Programming Interface (API)
Authors: Rahmansyah Ferdi , Nuryasin Ilyas , Hariyady Hariyady
Published: June 2022

Buku Sekolah Elektronik (BSE) merupakan salah satu upaya dalam peningkatan mutu pendidikan di indonesia,dengan adanya modul pembelajaran yang memiliki banyak metode pembelajaran untuk siswa kelas 1 sekolah dasar diharapkan untuk kedepannya dapat memberikan pemerataan nilai pendidikan menyeluruh ke seluruh wilayah tanpa terkendala harga buku yang mahal dan dapat dijangkau oleh seluruh lapisan masyarakat luas. Masalah yang sering ditemui adalah BSE belum dapat efektif dalam penerapannya karena terkendala media maupun pembelajaran oleh guru kepada siswa karena di buku tersebut hanya berupa text dan gambar yang tidak bergerak serta kurangnya siswa untuk turut aktif dalam pembelajaran. Dari permasalahan ini kemajuan dalam dunia teknologi dan informasi dapat menjadi sebuah solusi untuk memaksimalkan potensi dari BSE tersebut untuk pembelajaran siswa sekolah dasar.
PENERAPAN GENERALIZED ASSOCIATION RULE MINNING SEBAGAI ANALISA PASIEN PENDERITA KANKER PARU PARU BERDASARKAN DATA REKAM MEDIS
Authors: Putra Wiratama Rangga Kurnia
Published: June 2022

Penggunaan pada data rekam medis yang diambil dari database rumah sakit atau badan kesehatan bertujuan untuk mengetahui secara nyata riwayat pasien yang sebelumnya dinyatakan terkena kanker paru-paru. Namun potensi untuk mengetahui suatu pola penyakit secara manual berupa informasi secara langsung sangat memakan waktu sehingga dilakukan proses kegiatan analisa medis secara manual oleh dokter. Salah satunya adalah pola urutan penyakit pasien yang juga merupakan sebagai atribut pasien. Analisa diagnosa penyakit kanekr paru-paru dengan metode Association Rule menjadi teknik dari data mining yang diperlukan dalam menentukan model atribut dari database  rekam medis dari atribut yang sebelumnya dimiliki oleh seorang pasien. Berdasarkan data rekam medis yang akan diperiksa terdapat 1000 data dengan 3 kategori yaitu risiko rendah, risiko sedang dan risiko tinggi. batasan dari aturan asosiasi tersebut tak terhingga sehingga nilai support dan nilai confidence akan terdeteksi oleh program secara otomatis dan nilai tersebut akan dijadikan sebagai variabel evaluasi untuk melakukan klasifikasi untuk menentukan kategori yang mendekati.
Factors influencing internal whistleblowing. A systematic review of the literature
Authors:   B-secure, Kraków, Poland, Mrowiec Dawid
Published: June 2022

Aim/purpose – Internal whistleblowing is the most desirable form of reporting about wrongdoings for all kinds of organizations. The aim of this paper is to identify factors influencing the occurrence of internal whistleblowing and to provide recommendations for practitioners on how to encourage employees to report wrongdoings to an organiza- tion. Design/methodology/approach – The fundamental article database has been construct- ed with the use of ProQuest, EBSCO and Taylor & Francis databases. The timespan for the research was from 1990 to 2022. The papers for the fundamental database were found within the utilization of two words “whistleblowing” in titles and “internal” in abstracts. Next, the database was broadened by snowball review. Findings – Identified factors important for the occurrence of internal whistleblowing in an organization were assigned to one of the following areas: ethics, leadership, poli- cies and procedures, retaliations and safeguards, social climate, organizational justice, education and training, reporting channels, communication, additional motivation, organization’s size and structure, audit committee. Research implications/limitations – For researchers – the paper provides a picture of research on internal whistleblowing: identified factors influencing internal whistleblow- ing, popularity of exploring problems, and utilizing research methods. For practitioners – the paper provides practical implications (based on current knowledge) important for implementing and managing organizational whistleblowing systems in the organization of private and public sectors. Originality/value/contribution – The main contribution of this work states the frame- work of factors affecting internal whistleblowing, which was constructed on the basis of a systematic review of the scientific literature. Moreover, the paper provides guidelines for practitioners. Keywords: internal whistleblowing, factors, effectiveness, systematic review. JEL Classification: K22, L50, M10, M12, M14.
Efecto de la harina de cáscara de cacao (theobroma cacao) sobre el desempeño productivo de pollo de engorde
Authors: Flórez Delgado Dixon Fabián , Velásquez Prada Yingrid Marbelt
Published: June 2022

Contextualización: la cáscara de cacao es un residuo agroindustrial sin ningún valor comercial. Se genera en el lugar de recolección de este fruto durante su producción primaria y normalmente es abandonado en grandes pilas que generan problemas ambientales. Sin embargo, la cáscara de cacao posee propiedades nutricionales adecuadas que permiten su uso un en alimentación animal.
Vacío de conocimiento: existe poca evidencia científica del uso de la cáscara de cacao como alternativa alimenticia en pollo de engorde. 
Propósito: el objetivo de la presente investigación fue determinar el desempeño productivo de los pollos de engorde alimentados con cáscara de cacao, la cual se utilizó como reemplazo parcial del alimento balanceado comercial.
Metodología: se empleó un diseño aleatorizado con cinco tratamientos de inclusión de cáscara de cacao como reemplazo parcial del alimento balanceado comercial:   TCC2,5 %, TCC5 %, TCC7,5 %, TCC10 % y un control de cada uno con 25 réplicas.  Se   evaluaron   los siguientes parámetros productivos: consumo, peso corporal final, ganancia de peso, conversión y eficiencia alimenticia, rendimiento y peso en canal, peso de vísceras, pigmentación, costos por concepto de alimentación, ingreso neto parcial por pollo en pie e ingreso parcial por pollo en canal. Los resultados fueron sujetos al análisis de la varianza [ANOVA] con una significancia del 5 %, teniendo en cuenta el peso inicial como covariable. Los efectos lineales, cuadráticos y cúbicos fueron evaluados por contrastes ortogonales.     
Resultados y conclusiones: no se presentaron diferencias estadísticas para las variables de estudio entre el tratamiento control y los niveles de sustitución de alimento balanceado por harina de cáscara de cacao. Se presentó un efecto de orden lineal negativo para el rendimiento en canal y la pigmentación. No se observaron efectos de orden cuadrático y cúbico. Con relación al análisis económico, en los costos de alimentación se observa una disminución sustancial por kilogramo de carne producido para el TCC10 % respecto al grupo control y demás tratamientos; mientras que para el ingreso neto por pollo en pie e ingreso neto por pollo en canal, el TCC2,5 % presentó los valores más elevados. Se concluye que la sustitución parcial de alimento balanceado comercial por harina de cáscara de cacao en pollo de engorde no afecta el desempeño productivo y reduce sustancialmente los costos de producción.
Bisfenol a y efectos de disrupción endocrina en humanos y animales: Revisión sistemática
Authors: Tamayo Cabarcas Fernando , Agaméz Fuentes Jorge , Aparicio Marenco Dilia , Márquez Lázaro Johana
Published: June 2022

Contextualización:  El  Bisfenol  A  (BPA por  su  nombre  en  inglés,  Bisphenol  A) es  una  sustancia  química  utilizada  en  la fabricación  de  recipientes  de  plástico  de policarbonato,  recubrimiento  de  latas  de metal,  empaques  de  productos  cosméticos y  de  cuidado  personal,  utensilios  de  cocina, juguetes,  papel  térmico  para  recibos, equipos deportivos y dispositivos médicos y  dentales, que posee la facilidad de lixiviarse con  el  paso  del  tiempo  y  las  altas temperaturas. En la actualidad, el BPA se ha categorizado como disruptor endocrino, debido a su capacidad de alterar la homeostasis del sistema endocrino tanto de humanos como animales.
Vacío de investigación: El uso de plásticos se ha convertido en una problemática mundial, debido al impacto generado en los diferentes compartimientos ambientales, así como la salud de los animales y el hombre. En este sentido, se hace necesario la recopilación de información que evidencie el panorama general de los efectos asociados a sustancias presentes en los plásticos, tales como el BPA.
Propósito del estudio: Revisar los efectos de disrupción endocrina inducidos por la exposición a BPA en humanos y animales.
Metodología: Revisión sistemática de acuerdo con la guía PRISMA. Para ello se realizaron búsquedas en las bases de datos Scielo, ScienceDirect, MedLine (PubMed,OVID) entre el periodo de 2017 hasta 2021. Como palabras claves se emplearon los siguientes términos: Bisphenol, endocrine disrupter, animals y humans. Se incluyeron todos los artículos que evidenciaran el efecto disruptor endocrino del BPA en humanos y animales.
Resultados: Para esta revisión se incluyeron 35 estudios, de los cuales 17 se realizaron en humanos y 18 en animales; los estudios seleccionados evidenciaron que la exposición a BPA puede tener efectos sobre la reproducción, aumento de peso (obesógeno), diabetes, neurotoxicidad, estrés oxidativo y función tiroidea.
Conclusión: El BPA puede filtrarse de plásticos y productos y ser ingerido o absorbido por vía transdérmica en los seres vivos, así como lixiviarse al ambiente; allí puede alcanzar aguas residuales, suelo y cuerpos de agua (superficiales y subterráneos). Por tanto, esta sustancia es considerada como ubicua en el medio ambiente e inevitable para los humanos y animales, en los cuales ha mostrado inducir efectos de disrupción endocrina equiparables.
Identificación de aceites esenciales y parámetros productivos de Mentha spicata cultivada en sistemas acuapónicos y camas contenidas
Authors: Cardenas Laverde Diego , Torres Mesa Ana Constanza , Gómez Ramírez Edwin
Published: June 2022

Contextualización: Es de amplio conocimiento, el hecho que los sistemas de producción agrícola han estado en un proceso de mejora, para ser cada día más eficientes. Lo anterior con el objetivo de poder alcanzar la demanda básica de alimentos en un menor espacio. Los sistemas acuapónicos, permiten aumentar la producción de cultivos de interés comercial y nutricional, en una pequeña área, haciendo uso más racional de los recursos naturales• Vacío de conocimiento: En los sistemas acuapónicos, son pocos los estudios de aceites esenciales en plantas aromáticas, tanto a nivel nutricional como medicinal. Siendo la menta unos de los cultivos que presenta más potencial en la medicina alternativa por sus múltiples características bioactivas. • Propósito: El presente trabajo evaluó los metabolitos secundarios presentes en aceites esenciales de plantas de menta (M. spicata) de un sistema acuapónico con tilapia roja (Oreochromis sp.), en comparación con un cultivo en cama contenida. • Metodología: Se implementaron tres sistemas acuapónicos de 3m2 para siembra de plantas y la misma área en cultivos en cama contenida (9m2). Mensualmente se realizaron mediciones de crecimiento en las plantas y los peces. Semanalmente se midieron los parámetros de calidad de agua: NAT, nitrito, nitrato, fosfatos y pH.  Al final del cultivo se realizó la extracción de aceites esenciales por el método de arrastre por vapor. Luego obtuvieron las matrices y se caracterizaron bajo un modelo de CG-MS comparando el área y tiempo de retención de los compuestos hallados en ambos cultivos. • Resultados y conclusiones: Las muestras extraídas de los sistemas acuapónicos presentaron una mayor diversidad de compuestos en comparación con las camas contenidas. El compuesto más abundante en ambos sistemas fue la menta-Furanona, siendo mayor en los sistemas acuapónicos. La menta creció considerablemente mejor en los SA presentando una mayor biomasa, número de tallos y parámetros productivos. Este trabajo demuestra que los sistemas acuapónicos presentan una mayor diversidad de compuestos y un mejor rendimiento que un cultivo tradicional en cama contenida.
Electrocoagulación con radiación UV para remover DQO, COT y SDT en aguas residuales dela industria textil empleando electrodos de grafito
Authors: Rodriguez Oviedo María Alejandra , Sanchez Suarez Angela Daniela , Agudelo Valencia Rafael Nikolay
Published: June 2022

Contextualización: La industria textil hace uso de grandes cantidades de agua y diversas sustancias químicas que hacen parte de las distintas etapas del procesamiento, incluidos los procesos de pintura y acabado. Como resultado del uso de estas sustancias químicas, las aguas residuales de la industria textil presentan altas concentraciones de demanda química de oxígeno (DQO), carbono orgánico total (COT), sólidos disueltos totales (SDT) y baja biodegradabilidad.
Vacío de conocimiento: En la actualidad las distintas industrias en el país presentan fallas en la disposición final de las aguas residuales ya que se ha logrado identificar que algunas ciudades no cumplen con la normatividad que establece los valores límites máximos permisibles de vertimientos y algunos parámetros necesarios para la captación, transporte, tratamiento y disposición final de estas.
Propósito del estudio: La presente investigación tiene como objetivo evaluar el proceso de electrocoagulación empleando electrodos de grafito e intensificado por radiación UV en busca de determinar el porcentaje de remoción de DQO, COT y SDT en las aguas residuales de la industria textil.
Metodología: Se realizó una investigación experimental con el fin de evaluar la técnica de electrocoagulación intensificada por radiación con lámpara UV sumergible. Para el desarrollo metodológico se midieron algunos parámetros físicos y químicos antes y después de cada ensayo. Se llevó a cabo un diseño experimental de tipo factorial, con dos factores en tres niveles (32) es decir 9 ensayos, todos estos se realizaron por triplicado para un total de 27 experimentos. Los factores o variables seleccionados fueron el pH inicial del agua residual (6, 7 y 8) y la intensidad de corriente aplicada (0.5 A, 1 A y 1.5 A). Las variables de respuesta seleccionadas fueron el porcentaje de remoción de DQO, COT y SDT. Una vez realizados todos los ensayos, los resultados se analizaron por medio de análisis de varianza para determinar el efecto o influencia de cada factor sobre cada una de las variables de respuesta.
Resultados: Los ensayos permitieron determinar que las condiciones experimentales más favorables para el proceso de electrocoagulación fueron pH inicial 8 a una intensidad de corriente de 0,5 amperios. El proceso presenta alta eficiencia en cuanto al porcentaje de remoción de DQO, COT y SDT para cada uno de los ensayos lo cual es coherente teniendo en cuenta el uso de electrodos inertes que poseen una mayor resistencia química lo que facilita el proceso de oxidación y reducción en conjunto con el uso de radiación UV que intensifica el proceso por dar lugar a la formación de ozono y radicales OH* en el agua, en especial a pH alcalino, estos factores permiten alcanzar valores más altos en cuanto a la remoción de los distintos contaminantes presentes en el agua residual de la industria textil.
Relación entre nutrientes con carbono, nitrógeno y materia orgánica en suelos de la zona bananera de Colombia
Authors: Aguirre Forero Sonia Esperanza , Piraneque Gambasica Nelson Virgilio , Cruz O'Byrne Rosmery Katerine
Published: June 2022

Contextualización: El adecuado balance de nutrientes y su relación con la planta, permite un manejo sostenible del recurso edáfico donde la disponibilidad de los elementos nutrientes está condicionada por la concentración, la fijación y las perdidas en el sistema.
Vacío de conocimiento: En el Municipio de Zona Bananera no se ha identificado la concentración de nutrientes y sus posibles relaciones, lo que es de vital importancia para su manejo eficiente y el sostenimiento de la productividad del territorio.
Propósito: Por lo anterior, se planteó como objetivo analizar el pH, la concentración de macro y micro elementos y su relación con contenidos de Carbono oxidable (Cox), Nitrógeno total (Nt) y Materia orgánica, (MO), en suelos del municipio Zona Bananera (Magdalena).
Metodología: Durante el año 2020 mediante muestreo aleatorio simple de 25 puntos a dos profundidades (0-10 y 10 -20 cm). Se determinó la concentración de elementos nutriente (P, K, Ca, Mg, Na, S, Fe, Mn, Cu, Zn, B y S) y su relación con Nt, MO y Cox, seguido de la priorización de alternativas para manejo sostenible mediante matriz multicriterio con enfoque multidisciplinario.
Resultados y conclusiones: Se evidenció que suelos cultivados, presentan altos contenidos de MO y N con correlación significativas con las variables medidas, ratificando que el contenido de Cox y MO incide sobre la fluctuación del N y otros nutrientes, por lo que el monitoreo de este elemento es primordial para sostenibilidad del sistema.
Poultry manure increases soil fertility, growth and nutritional status of yerba mate seedlings
Authors: Moreno Gabira Mônica , Santin Delmar , Wendling Ivar , Benedetti Eliziane Luiza
Published: June 2022

Contextualization: The use of organic fertilizers from agricultural industry residues is an alternative as a nutritional source in agroforestry cultures, mainly due to the slow release of nutrients. The leaf biomass production is essential for yerba mate production, which demands adequate nutritional management to maintain productivity and soil fertility.
Knowledge gap: Most yerba mate is produced with the use of mineral fertilizers, and there are no records of how organic fertilization with poultry manure could influence plants growth, nutritional status, and soil fertility.
Purpose: This study aimed to evaluate the influence of organic fertilization on soil fertility, growth, and nutritional status of yerba mate seedlings.
Methodology: Two clonal cultivars of yerba mate (BRS408 and BRS409) were subjected to three fertilization doses with poultry manure (0, 20, and 35 g dm-3). The study was established in a factorial design, in a randomized block design with four replications. After 210 days, pH, organic matter content, availability of P, K, Ca, and Mg in the soil were analyzed. In addition, plants were evaluated in the same period for growth and leaf content of N, P, K, Ca, Mg, and S. Data were subjected to ANOVA and Tukey test for means comparison.
Results and conclusions: Organic fertilization positively influenced soil characteristics and yerba mate seedlings growth, with significant differences in the response of each clone. The use of 20 g dm-3 of poultry manure is recommended for yerba mate seedlings production.
Deep subcutaneous cervical emphysema related to mastoid fracture in an adolescent patient - case report
Authors: Paouris Dimitrios , Barkociová Jana , Šebová Irina
Published: June 2022

A fracture of the mastoid bone should be considered in the work-up of a
head and neck traumatic injury. A well-pneumatized mastoid can absorb
forceful impacts, protecting middle and inner ear structures. Fractures
of the mastoid, followed by Valsalva maneuver can lead to subcutaneous
cervical emphysema.
Fabrication of a Mandibular Implant Retained Overdenture Using an Existing Subperiosteal Implant: A Clinical Report
Authors: Arshad Mahnaz , Khoramshahi Nourin , Shirani Gholamreza
Published: June 2022

A 64-year-old edentulous woman with a mandibular fracture received a
subperiosteal implant for fracture fixation and dental rehabilitation.
Unfortunately, the ball abutments were covered by soft tissue because
they were too short. Therefore, we designed a connector to lengthen the
attachment and achieve adequate stability and retention for the
overdenture.
Multimodality imaging of a rare right ventricular angioleiomyoma
Authors: Fu Wenpei , Zhu Liangru , Xie Mingxing , Zheng Liduan , Yang Yali
Published: June 2022

We report a rare case of right ventricular angioleiomyoma in a 35-years
old man diagnosed by multimodality imaging, including echocardiography,
cardiac magnetic resonance imaging (CMR), Positron emissions tomography
(PET) and Computer tomography angiography (CTA). The imaging results
were finally confirmed by surgery. We present the clinical value of
multimodality imaging in diagnosing cardiac angioleiomyoma.
Uncovering new poloxamer attributes significantly impacting mammalian cell growth performance
Authors: Safta Jade , Case Katarzyna , Brandt Lori , Matathia Alice , Hsieh Ming-Ching , Blanc Timothy , Huang Lihua , Goetz Victor , Dorundo Dane
Published: June 2022

A biopharmaceutical grade poloxamer designed with less hydrophobic
contaminants and shown to resolve growth issues for mammalian cell lines
was implemented in a commercial biopharmaceutical process and expected
to improve protection of cells from hydrodynamic stress
[[1]](#ref-0001). However, contrary to expected results, the
cell growth and resultant titer further declined. This was not
consistent with prior reports in literature [[2]](#ref-0002),
which demonstrated that these hydrophobic contaminants present in P188
poloxamer contributed to low performance due to inefficiency in
protecting cells from shear stress. An analytical screening tool as well
as a novel, high shear stress bioreactor model was developed and used to
determine that an overall higher poloxamer average molecular weight was
actually the root cause of poor growth in this SP2/0 production cell
line. This demonstrates an increased SP2/0 sensitivity to subtle
differences in poloxamer molecular weight distribution.
Ca 2+ Deficiency Triggers Panicle Degeneration in Rice Mediated by OsCAX1a
Authors: Gan Quan , Zhang Chuanzhong , Han Zhongmin , Song Fengshun , Lin Cuixiang , Wang Jiajia , Pei Huan , Wu Ji , Fang Jun , Ni Dahu
Published: June 2022

Increasing the yield of rice has always been a primary purpose of rice
breeding. However, panicle degeneration, a complex characteristic
regulated by many genes and commonly encountered in rice production,
seriously reduces the yield. In this study, we obtained a new apical
panicle degeneration mutant named ym48, which exhibits a serious
degeneration rate and reduced grain yield in rice. Cellular and
physiological analyses revealed that the apical panicle in ym48
undergo programmed cell death, accompanied by accumulation of higher
levels of peroxide. Following, the OsCAX1a gene responsible for
Ca transportation was identified and a highly
conserved A to G substitution was noted at the 190
nucleotide in ym48, which damaged Ca
transport ability seriously. Through hydroponics assay and Ca
quantified, we found that Ca
transportation and distribution from underground part to apical tissues
was blocked and over-accumulated in mutant stem. In general, this Ca
deficiency mediated by OsCAX1a induced
peroxide accumulation and resulted to programmed cell death in apical
panicle of ym48 mutant. Our results demonstrated the essential
role of OsCAX1a in Ca transportation and
distribution, and laid a foundation to further explore the genetic and
molecular mechanisms of panicle development and differentiation in rice.
Hypoxia activates GPR146 which participates in pulmonary vascular remodeling by promoting pyroptosis of pulmonary artery endothelial cells
Authors: Jiang Yanjiao , Huang Jie , Xia Yu , Sun Zengxian , Hu Panpan , Wang Dapeng , Liu Yi , Tao Ting , Liu Yun
Published: June 2022

Background and Purpose：Hypoxia, as a risk factor for pulmonary
hypertension (PH), was an inducing factor for pulmonary artery
endothelial cells (PAECs) injury and inflammation. Pyroptosis induced
cell death along with the maturation and secretion of the inflammatory
mediators. However, the correlation among pyroptosis, PAECs injury and
inflammation remain unknown. Here, we explored, in detail, the effect of
hypoxia on pyroptosis of PAECs. Experimental approach：Using RNA-seq
sequencing method, we screened differentially expressed genes in
pulmonary artery in SU5416-induced hypoxia PH model. Next, we verified
the role and mechanism of the differentially expressed gene GPR146 in
PAECs by immunohistochemistry, immunofluorescence, CCK8, western
blotting, realtime PCR, and LDH release experiments. Key Results: Our
results showed that GPR146 was highly expressed in PH human lung tissue
and Sugen5416/hypoxia (SuHx) induced rat PAH lung tissues. Meanwhile,
our data suggested the expression of pyroptosis-related proteins was
remarkably increased under hypoxia both in vivo and in vitro, which were
inhibited by silencing GPR146. Moreover, inhibiting NLRP3 or caspase-1
effectively suppressed cleavage of caspase-1, production of interleukin
(IL)-1β and IL-18 in PAECs by hypoxia and overexpression of GPR146.
Conclusion and Implications: Our results indicated that GPR146 induced
pyroptosis and inflammatory responses through the NLRP3/caspase-1
signaling axis, triggering endothelial injury and vascular remodeling.
Hypoxia could promote PAECs pyroptosis through upregulation of GPR146 to
affect the progression of PH, which might provide novel targets for
treatment of PH.
Towards Data Storage Security in Cloud Computing Using Hybridized Advanced Encryption Standard & Authentication Scheme
Authors:   Department of Computer Technology, Lagos State Polytechnic, Ikorodu, Lagos State, Nigeria Faculty of Computational Sciences & Informatics, Academic City University College, Accra, Ghana, Sarumi Jerry Abayomi , Longe Olumide Babatope
Published: June 2022

Cloud computing is at the heart of modern day computing and thus the rise in malicious attacks are increasing every day towards it. In recent times hackers have been engaging in different string concept on login fields and phishing in order to intrude cloud accounts. This research is proposed to carry out effective security mechanisms on loopholes in cloud data storage. We intend to engage the use of the Advanced Encryption Standard (AES), security Algorithms like Secure Hash Algorithm 1 & 3 (SHA1, SHA 3) and Message-Digest Algorithm (MDS) and the Standard Authentication Scheme (AS) as sure guide against phishing which when implemented can provide various login stages and codes like OTP (One Time Password) to mitigate attacks. With the application of these methods towards securing cloud computing data there will be less intrusion in accounts and loss of files. Keywords: Brute-force, Cracking, Hacking, Advanced Encryption Standard, Authentication Scheme, AES, ES, Security
Model for Integration of Monogenic Diabetes Diagnosis Into Routine Care: The Personalized Diabetes Medicine Program
Authors: Zhang Haichen , Kleinberger Jeffrey W. , Maloney Kristin A. , Guan Yue , Mathias Trevor J. , Bisordi Katharine , Streeten Elizabeth A. , Blessing Kristina , Snyder Mallory N. , Bromberger Lee A. , Goehringer Jessica , Kimball Amy , Damcott Coleen M. , Taylor Casey O. , Nicholson Michaela , Nwaba Devon , Palmer Kathleen , Sewell Danielle , Ambulos Nicholas , Jeng Linda J.B. , Shuldiner Alan R. , Levin Philip , Carey David J. , Pollin Toni I.
Published: June 2022

OBJECTIVE

To implement, disseminate, and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes.

RESEARCH DESIGN AND METHODS

Patients were recruited into the implementation study through a screening questionnaire completed in the waiting room or through the patient portal, physician recognition, or self-referral. Patients suspected of having monogenic diabetes based on the processing of their questionnaire and other data through an algorithm underwent next-generation sequencing for 40 genes implicated in monogenic diabetes and related conditions.

RESULTS

Three hundred thirteen probands with suspected monogenic diabetes (but most diagnosed with type 2 diabetes) were enrolled from October 2014 to January 2019. Sequencing identified 38 individuals with monogenic diabetes, with most variants found in GCK or HNF1A. Positivity rates for ascertainment methods were 3.1% for clinic screening, 5.3% for electronic health record portal screening, 16.5% for physician recognition, and 32.4% for self-referral. The algorithmic criterion of non–type 1 diabetes before age 30 years had an overall positivity rate of 15.0%.

CONCLUSIONS

We successfully modeled the efficient incorporation of monogenic diabetes diagnosis into the diabetes care setting, using multiple strategies to screen and identify a subpopulation with a 12.1% prevalence of monogenic diabetes by molecular testing. Self-referral was particularly efficient (32% prevalence), suggesting that educating the lay public in addition to clinicians may be the most effective way to increase the diagnosis rate in monogenic diabetes. Scaling up this model will assure access to diagnosis and customized treatment among those with monogenic diabetes and, more broadly, access to personalized medicine across disease areas.
A Model for Integration of Monogenic Diabetes Diagnosis into Routine Care: The Personalized Diabetes Medicine Program
Authors: Zhang Haichen , Kleinberger Jeffrey W. , Maloney Kristin A. , Guan Yue , Mathias Trevor J. , Bisordi Katharine , Streeten Elizabeth A. , Blessing Kristina , Snyder Mallory N. , Bromberger Lee , Goehringer Jessica , Kimball Amy , Damcott Coleen M. , Taylor Casey O. , Nicholson Michaela , Nwaba Devon , Palmer Kathleen , Sewell Danielle , Ambulos Nicholas , Jeng Linda J.B. , Shuldiner Alan R. , Levin Philip , Carey David J. , Pollin Toni I.
Published: June 2022

  

Objective: To implement, disseminate and evaluate a sustainable method for identifying, diagnosing, and promoting individualized therapy for monogenic diabetes. 

Research Design and Methods: Patients were recruited into the implementation study through a screening questionnaire completed in the waiting room or through the patient portal, physician recognition, or self-referral. Patients suspected of monogenic diabetes based on the processing of their questionnaire and other data through an algorithm underwent next-generation sequencing for 40 genes implicated in monogenic diabetes and related conditions.

Results: Three hundred thirteen probands with suspected monogenic diabetes (but most diagnosed with type 2 diabetes) were enrolled from October 2014 to January 2019. Sequencing identified 38 individuals with monogenic diabetes, with most variants found in GCK or HNF1A. Positivity rates for ascertainment methods were 3.1% in clinic screening, 5.3% in EHR portal screening, 16.5% for physician recognition, and 32.4% for self-referral. The algorithm criterion of non-type 1 diabetes before age 30 years had an overall positivity rate of 15.0%.  

Conclusions: We successfully modeled the efficient incorporation of monogenic diabetes diagnosis into the diabetes care setting, using multiple strategies to screen and identify a subpopulation with a 12.1% prevalence of monogenic diabetes by molecular testing. Self-referral was particularly efficient (32% prevalence), suggesting that educating the lay public in addition to clinicians may be the most effective way to increase the diagnosis rate of monogenic diabetes. Scaling up this model will assure access to diagnosis and customized treatment for monogenic diabetes and more broadly access to personalized medicine across disease areas. 
Change of Editor-in-Chief
Authors: Vahlquist and Agneta Andersson Anders
Published: June 2022

Abstract is missing (Editorial)
Introduction: Responding to a Changing Arctic Ocean: Canadian and Russian Experiences and Challenges
Authors: Gavrilov Viatcheslav , VanderZwaag David L. , Rolston Susan J.
Published: June 2022

This article is the guest editors' introduction to the special series entitled Responding to a Changing Arctic Ocean: Canadian and Russian Experiences and Challenges.
Rastreamento do Risco de Disfagia em Pacientes com Doenças Pulmonares
Authors: Penna Letícia Macedo , Nascimento Gabriela Salvi da Silva , Guimarães Michelle Ferreira , Nunes Janaina de Alencar , Azevedo Elma Heitmann Mares
Published: June 2022

Introdução: As doenças pulmonares são frequentemente associadas com aumento da morbidade e mortalidade pelo comprometimento ventilatório e impacto negativo na proteção de via aérea inferior, além de favorecer uma dissincronia entre a deglutição e respiração comprometendo a função, prazer, qualidade de vida, podendo levar ao óbito. Objetivo: Identificar o risco de disfagia em pacientes com doenças pulmonares. Método: Estudo transversal, descritivo, realizado de março/2016 a julho/2019, em um Hospital Universitário. Foram incluídos pacientes com idade igual ou superior a 18 anos, de ambos os sexos, independente de fatores associados, com estado de alerta suficiente para responder o instrumento; e excluídos pacientes com dificuldades quanto à compreensão das sentenças e/ou instruções, com rastreios prévios, em acompanhamento fonoaudiológico, indisponibilidade para participar do estudo, ausência no leito ou instabilidade do quadro clínico. Foram coletados os dados sociodemográficos, as variáveis clínicas e aplicado o instrumento Eating Assessment Tool (EAT-10). Para análise estatística foi considerado o nível de 5% de significância. Resultados: Participaram 99 pacientes com prevalência do sexo masculino (54,5%), idade acima de 60 anos (57,6%) e diagnóstico de tuberculose (16,1%). Houve risco de disfagia em 15 (15,2%) pacientes com prevalência de enfisema pulmonar (26,6%) e pneumonia (20%). Não foi observada associação entre risco de disfagia e sexo, idade, intubação orotraqueal, traqueostomia, via alternativa de alimentação, refluxo gastroesofágico, disfonia e doença de base pulmonar. Conclusão: Por meio de uma ferramenta rápida e simples de rastreamento foi observada a presença do risco de disfagia em 15,2% dos pacientes com doenças pulmonares.
Distúrbio de voz e qualidade de vida em professores
Authors: Ferreira Léslie Piccolotto , Paes Juliana Côrtes , Tozzo Ana Paula da Silva , Latorre Maria do Rosário Dias de Oliveira , Giannini Susana Pimentel Pinto
Published: June 2022

Introdução: percepção do indivíduo sobre sua voz e impactos no cotidiano tem sido objeto de estudos que buscam a relação entre qualidade de vida e bem-estar. Objetivo: analisar a relação entre qualidade de vida e presença de distúrbio de voz em docentes da rede municipal de São Paulo. Método: estudo do tipo caso-controle, pareado por escola, com 272 professoras da rede municipal de ensino de São Paulo (167 casos e 105 controles), responderam questionários Condição de Produção Vocal-Professor e World Health Organization Quality of Life/bref, avaliados fonoaudiológica e otorrinolaringológicamente. Foi realizado teste de associação de Qui-quadrado para análise entre a presença de distúrbio de voz e os domínios do WHOQOL/bref. e modelos de regressão logística para calcular a Razão de Chances bruta e ajustada para avaliar riscos em relação às variáveis independentes de interesse. Resultados: os grupos mostraram-se semelhantes quanto a dados sociodemográficos, situação funcional, ambiente e organização de trabalho, e diferentes na autorreferencia a sintomas vocais, confirmando a natureza de estudo caso-controle. Na análise descritiva de cada um dos domínios do WHOQOL/bref, o referente ao meio ambiente apresentou pior média, seguido pelo físico, psicológico e relações sociais. O domínio físico apresentou significância estatística se comparado aos outros domínios, seguido pelo psicológico e do meio ambiente. Não houve diferença significativa sobre as relações sociais. Conclusão: houve associação entre presença de distúrbio de voz e comprometimento do domínio físico da qualidade de vida, havendo um aumento de chances de quase três vezes de quem tem distúrbio vocal apresentar baixos escores no referido domínio.
Linguagem, interação e vulnerabilidade comunicativa na relação de cuidado ao paciente
Authors: Carvalho Milena de Souza , Zerbeto Amanda Brait , Chun Regina Yu Shon
Published: June 2022

Introdução: A linguagem entre os homens evoluiu ao longo da história. Comprometimentos de fala e linguagem podem acarretar em situação de vulnerabilidade comunicativa, influenciando na participação da pessoa no processo terapêutico e tomada de decisões clínicas. Objetivo: Investigar a percepção de futuros profissionais de medicina, fonoaudiologia e enfermagem quanto à comunicação com o paciente a partir de vivências nos campos de estágios. Método: Estudo transversal, descritivo e quantitativo, com amostra de 85 alunos. Para a coleta de dados utilizou-se questionário online. Resultados: Todos participantes consideraram importante, ou muito importante, a comunicação com o paciente. Para a maioria dos participantes de fonoaudiologia (84,8%) e de medicina (65,6%) a comunicação com os pacientes é efetiva, enquanto que os de enfermagem (55%) referiram certa dificuldade. 35% dos alunos de enfermagem e 28,1% dos de medicina informaram que não tiveram contato com pacientes não oralizados; 33,3% dos alunos de Fonoaudiologia responderam que, nesses casos, a comunicação é efetiva, pois eles utilizavam outras formas de comunicação. Todos consideraram que o não falar coloca o paciente em situação de vulnerabilidade. Conclusão: Os resultados evidenciam que a comunicação paciente-futuro profissional de saúde é considerada importante para todos os participantes. Os achados reiteram a importância da temática na graduação e da comunicação na relação paciente-profissional para o bem-estar de vida e saúde da pessoa, sendo essa questão responsabilidade da equipe e não apenas do fonoaudiólogo, tendo em vista uma formação e atenção integrada e humanizada.
Fonoaudiologia no Núcleo Ampliado de Saúde da Família e Atenção Básica
Authors: Martins Wiliane de Souza , Silva José Marcos da , Sousa Fabiana de Oliveira Silva
Published: June 2022

Objetivo: caracterizar a atuação de profissionais fonoaudiólogos na saúde vocal de professores, no âmbito da Atenção Primária à Saúde, em um município do Nordeste do Brasil. Métodos: trata-se de um estudo de caso, com abordagem qualitativa. Participaram da pesquisa cinco profissionais fonoaudiólogas inseridas no Núcleo Ampliado de Saúde da Família e Atenção Básica. A coleta de dados foi realizada a partir de entrevistas semiestruturadas. Os dados foram interpretados por meio da técnica de análise de conteúdo. Resultados: caracteriza-se a atuação fonoaudiológica na Atenção Primária em Saúde e saúde vocal de professores. São identificadas atividades realizadas pelos Núcleos de Apoio à Saúde da Família que favorecem o reconhecimento da Atenção Primário em Saúde como local virtuoso para ações de promoção da saúde e prevenção de agravos por meio de ações de Vigilância em Saúde do Trabalhador (a). O Programa Saúde na Escola é reconhecido como potente dispositivo para a realização de ações intersetoriais para a implementação do Protocolo de Distúrbios da Voz Relacionado ao Trabalho. Conclusão: as atividades realizadas pela fonoaudiologia se caracterizam por ações de promoção da saúde, realizado em equipe multiprofissional que assume o cuidado sobre um território. Existem limitações e desafios para o melhor desenvolvimento das ações que foram intensificadas pela pandemia de COVID-19. Importa que sejam realizados outros estudos que aprofundem a problemática. A fonoaudiologia é uma categoria profissional que contribui para a saúde das pessoas nos seus locais de vida e trabalho, tornando-se fundamental sua inserção na Atenção Básica do Sistema Único de Saúde.
Preparation and research of gelatine hydrogel anti-bedsore materials properties
Authors:   Lviv Polytechnic National University, Maikovych O. , Nosova N. ,   Lviv Polytechnic National University, Nadashkevych Z. ,   Lviv Polytechnic National University, Varvarenko S. ,   Lviv Polytechnic National University
Published: June 2022

The formation of the hydrogel polymer matrix duringthe gelatin cross-linking with dioxirane derivatives of polyoxyethylene glycolswere studied.The optimal conditions for their synthesis were determined. The characteristics of the hydrogel (swelling in different media, mechanical properties at different temperatures) were obtained depending on the type of dioxirane derivative and prepolymer ratio. The possibility of introducing several drugs into hydrogels was established and the release of these drugs was found to be prolonged.
Kirja-arvio
Authors: Kettunen Pekka
Published: June 2022

Saukkonen, Pasi: Suomi omaksi kodiksi. Kotouttamispolitiikka ja sen kehittämismahdollisuudet.(2020)
Yogyakarta Lecturers' Experience in Using Mobile Phone in English Language Teaching
Authors: Rohmah Farida Noor , Aditya David Sulistiawan
Published: June 2022

This study is aimed at investigating lecturers’ experience in using mobile phone in English teaching practice. Employing qualitative method using Creswell (2014), the study collected data through in-depth-interview and analyzed data through several steps including data preparation and organization, data reading, data coding, data description, data interpretation, and data presentation. The result of the study indicated that the lecturers mostly implemented MALL and utilized mobile phone for three main purposes, namely instructional need, content understanding development, and communication. However, it was found that problem of internet connection became a barrier to fully implement MALL in ELT.
Investigating Translation Techniques through Theme-Rheme Analysis
Authors: Ulwiyah Imaratul
Published: June 2022

ABSTRACT Translation is the process of transferring a message from one language to another with consideration to the equivalence. In the practice of translation, forms may change. The practice of translation should be done on the basis of linguistic theories as tools. Since the translator is concerned exclusively and continuously with meaning, it is not surprising that Halidayan linguistics which sees language primarily as a meaning potential should offer itself as a serviceable tool for determining the constituent part of a source language text network of relations with its translation. Therefore, this research will identify the translation technique through the information structure theories (Theme-Rheme) and its readability in BabyShark StoryBook Series. The method used in this study is qualitative descriptive. The data collection was conducted by using observation and note-taking techniques. Ten young children became target readers for the assessment to the readability of the translated text. The results show that the Theme-Rheme analysis can lead to find the translation techniques which were applied. They are Modulation, Transposition, Reduction and Amplification. The data reported here appear to support the assumption that the translator applied linguistic simplification and over explicitation in order to children fully grasp the text.Keywords:translation, theme-rheme, translation technique, readability
Encountering Prospective Teachers’ and Lecturers’ Lesson Study for Learning Community (LSLC) Experience in Microteaching Class
Authors: Tiarina Yuli , Hashim Harwati , Rozimela Yenni , Adnan Aryuliva
Published: June 2022

Considering the effectiveness of Lesson Study as a continue teacher development, this study was conducted to explore prospective teachers’ and lecturers’ experience in implementing Lesson Study in Microteaching class. Quantitative research approach was employed where a total of 49 prospective teachers and 2 Microteaching lecturers at English Department of Universitas Negeri Padang were involved as the participants. The data were gathered through questionnaires with 1-5 Likert scales consisting of four sessions. The results indicate that prospective teachers and lecturers have positive experience in implementing lesson study for learning community with the mean score 3.75 and 4.08 out of 5. It is supported by the Mann Whitney U test where the value with 1-tailed (.358) was bigger than level of probability α (0.05). They perceived that LSLC promotes to improve the ability of collaboration between members of the learning community and facilitates the process of teaching and learning in Microteaching classes in preparing teaching material and teaching strategies for teaching in microteaching class. Therefore, it is suggested that LSLC must be implemented continuously to improve teachers’ pedagogical competency and collaboration skills.
The Voice of Human Ecology in the Novel The Bear (2020) by Andrew Krivak
Authors: Sabrina Annisa
Published: June 2022

As a movement that has held an important position in the humanities for the past few decades, eco-criticism or environmental-oriented literature needs to promote a better understanding of nature more broadly. That is, ecocriticism must distinguish itself from writings on the environment in general, namely by presenting a narrative showing that humans need to have a sense of attachment to nature, as well as by presenting a narrative showing that the world of humans and the world of non-humans needs to be positioned equally. In the novel The Bear (2020) by Andrew Krivak, the voice of equality between humans and nature is the dominant issue. Using the human ecology concept from Philip J. Stewart as a key concept, this study aims to describe how human fragility and natural domination presented in the novel The Bear (2020) support the idea of human ecology, as well as how human ecologyvoiced in the novel The Bear (2020) criticizes the view of anthropocentrism which believes that humans are the center of life. This study shows that the voice of human ecology in the novel The Bear (2020) which is presented through human fragility, natural domination, to criticism of the anthropocentrism view offers the idea of a balance between humans and nature. The balance in question is a condition in which humans and nature return to an equal position, where neither one of them is harmed.