bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinación del ángulo de giro para la extracción de plugs en núcleos preservados usando imágenes de tomografía de rayos X
Authors: Herrera-Otero Edwar , Badillo-Requena Juan , Pereira-Santana Zaida Carolina
Published: July 2022

Los plugs son submuestras extraídas de núcleos de perforación, los cuales son usados para medir directamente propiedades asociadas a la roca y a la interacción con el fluido; cualquier modelo petrofísico debe tener datos de laboratorio provenientes de estos para su debida calibración, de allí su importancia. En consecuencia, el presente trabajo plantea una metodología que permite determinar con exactitud la ubicación de puntos de interés, incluido el ángulo de giro del núcleo, para su posterior extracción; esto asegura la integridad y representatividad, una vez que exista la ubicación de la zona de interés mediante registros de pozo. La metodología usa imágenes de tomografía de rayos X en los cortes axiales, radiales y verticales. Se encontraron ecuaciones que permiten medir directamente en imágenes escaladas el ángulo de buzamiento real en las imágenes cilíndricas y el aparente en los cortes verticales; adicionalmente, se crearon dos nomogramas que permiten determinar el ángulo de giro del núcleo de perforación, una vez calculados los datos de buzamiento de la estructura planar de interés.
El ecosistema social y los modos de supervivencia individual. Criterios para estudiar la corrupción y la criminalidad
Authors: Bustamante Fontecha Alejandro
Published: July 2022

Este ensayo aborda una interpretación de la violencia, la criminalidad y la corrupción en la sociedad, a partir del estudio de un cúmulo de fuentes de diversa índole, y del análisis crítico de las interpretaciones vigentes. Por ello, se discuten, con cierto detalle, los efectos perniciosos del predominio del platonismo en la interpretación de dichas fuentes, y se propone, de la mano de Nietzsche y del pensamiento evolucionista, un abordaje del problema, que, apoyado en la perspectiva del platonismo invertido planteado por el filósofo, concibe la sociedad como un ecosistema, esto es, un sistema vivo, donde cada individuo debe enfrentar el reto de sobrevivir, arreglándoselas para obtener recursos que aseguren su existencia. Así, hemos identificado diferentes modos de supervivencia y los hemos clasificado en tres categorías: 1) generadores (creadores-productores); 2) saqueadores (parásitos, predadores y oportunistas) y, 3) simbiontes (mutualistas y leoninos).
Reseña. El smartphone de Anteo: tecnología y ecología en el Antropoceno
Authors: Lanza González Henar
Published: July 2022

Almazán, A. (2021). Técnica y tecnología. Cómo conversar con un tecnolófilo. Taugenit. 180 pp.
Evolution of Crack Propagation Rate in Notched Specimens Using XFEM Method under Bending Load Condition
Authors: Zergot Souad , Moussaoui Mustafa , Hachi Brahim Elkhalil
Published: July 2022

The crack initiation and propagation often occur in structures subjected to fatigue loads and their privileged sites it is the geometric discontinuity in particular the notches. The geometric configuration of the notches always leads to disturbances of stress fields in the vicinity of the notch end as a consequence of the effects on the crack initiation site and on the crack rate. The present study is interested to the evolution of crack speed propagation in the notched specimens subjected to bending. The specimens chosen are made of PMMA material containing two opposite notches U or V that presented two different parameters, a radius for U-notch and angle for V-notch. The variations taken into account for the sharp notches (V-notch) going from the small angle to the large angle, which are 30°; 45°, 90°, and 140°, and for blunt notches (U-notch) the radius takes the different values 0.5, 1, 1.5, and 2 mm. The fracture brittle behavior adapted to this material led to predict the Fatigue crack growth using a modified form of Paris’s law with the equivalent stress intensity factor (ΔKeq) relying on extended finite element method (XFEM) in order to follow the interaction between the notch and the crack on one side and study the evolution of crack growth rate to another side. The variations, which brought to these parameters entailed an influence on the crack propagation speed, which was born at the end of notch of component as well as the variations of equivalent notch intensity stress factors (ΔKeq). The variations made to the parameters of notches have a huge influence on the crack propagation rate.
Designing a decision support system scheme based on the ontology of recomposable manufacturing
Authors:   Orenburg State, Orenburg, Russia, Pishchukhina T.A.
Published: July 2022

The purpose of the work is to design a scheme of the DSS of a recomposable manufacturing using an ontological approach and mathematical modeling. The decomposition of the production process in the recomposed manufacturing is carried out, the main influencing factors are identified. The conceptual scheme and hierarchy of classes of the constructed ontology of the subject area are given. In order to take into account the priority of influencing factors and identify the controlling influences affecting the speed of reconfiguration of the recomposed manufacturing, the Ishikawa cause-and-effect diagram was developed. A formalized description of the process of choosing the optimal way to reconfigure the system is proposed. A DSS scheme for the reconfigurable manufacturing has been developed, based on the consideration of temporal and spatial factors of the reconfiguration. A recomposition time structure is proposed, which allows optimizing several factors at the same time. An example of optimizing the recomposition time of a recomposable manufacturing area using the Bellman dynamic programming method and graph theory is demonstrated.
Decision support when choosing a global illumination method based on a cross-platform application
Authors:   Ufa State Aviation Technical University, Ufa, Russia, Kiselyov A.V. , Yusupova N.I. ,   Ufa State Aviation Technical University, Ufa, Russia
Published: July 2022

Decision-making technology is considered on the example of developing a specialized DSS for developers of information visualization systems. An urgent task is to support the choice of a global illumination method from more than 60 existing ones. The formulation of this problem is based on the analysis of the subject area of global illumination methods and the accepted indicators for their evaluation. The simplest options for organizing a rational solution to the problem are given. The developed DSS is a desktop cross-platform software application based on the AvaloniaUI platform, which can be used as an example of typical solutions to such problems.
La reconfiguración de los CANI desde el paradigma de la realpolitik (versiones clásica y neo)
Authors: Muñoz Jiménez Anakaren , García Gómez Jazmín
Published: July 2022

El objetivo del presente artículo es revisar las dos versiones que componen el paradigma de la realpolitik, con miras a revelar cuál de ellas posee mayor oportunidad de adaptación para explicar los Conflictos Armados No Internacionales (CANI), que se han reconfigurado desde 1989. Ante ello, se sostiene la hipótesis de que la versión neo de la realpolitik de Waltz ofrece un abordaje más integral para analizar la dinámica de los CANI reconfigurados que la versión clásica de la realpolitik de Morgenthau. Ya que su implementación de los tres niveles sistémicos y sus conceptos renovados de actor, interés y poder permiten analizar con mayor apertura las causas, el desarrollo y las consecuencias de estos enfrentamientos. Para comprobar su alcance teórico se examinará desde el neorrealismo político el ejemplo particular de la Segunda Guerra Civil de la República Democrática del Congo o RDC (1998-2003). El artículo se divide en tres partes. La primera expondrá los conceptos más relevantes de la investigación. La segunda buscará construir un marco teórico necesario para analizar el objeto de estudio. Y la tercera pondrá en práctica lo aprendido en el CANI seleccionado. Todo ello permitirá exponer las virtudes y las limitaciones de la realpolitik con respecto a los cambios producidos en la dinámica armada, propondrá renovar el paradigma acorde con un análisis más abierto y flexible para estudiar las disputas actuales y, finalmente, ayudará a brindar la información necesaria sobre cómo apaciguar el conflicto que aún sufre la RDC.
Surgical treatment of a complex fracture of the lower jaw
Authors: Turahanov Saidkamol  Valievich , Khramova Natalya Vladimirovna , Machmudov Alisher Akhmedovich
Published: July 2022

The aim of the study was to improve the effectiveness of surgical care for patients with complex jaw fractures by combining modern methods of fixing bone fragments. A plan of surgical treatment was formed, which is illustrated in this article on the example of a clinical case. The complex included several stages: examination, planning, preparation for surgery, surgery, patient rehabilitation. For complex fractures of the lower jaw, especially in the area of ​​the articular process, a combination of several surgical methods is recommended to achieve full contact of fragments in the area of ​​the fracture.
Construcción de privilegios y actitudes hacia la riqueza: percepciones y creencias de madres y padres de colegios de élite en Chile
Authors: Alfaro Juan , Atria Jorge , Ortúzar Santiago
Published: July 2022

Este artículo aborda la construcción y reproducción de privilegios en la mirada de hombres y mujeres de élite en Santiago de Chile. Basándose en 24 entrevistas semiestructuradas realizadas a madres y padres de cinco prestigiosos colegios, se presentan tres dimensiones del privilegio que configuran distintas actitudes hacia la riqueza: remisión al pasado familiar, aprovechamiento de oportunidades, y actitud de naturalidad. Así entendido, el privilegio incide en la selección de un determinado establecimiento educativo, aunque este adquiere distintas comprensiones en cada uno. El artículo releva la importancia de la construcción de privilegios como clave para expandir la investigación sobre las élites y la reproducción de desigualdades.
BIOSENSOR FOR ALT MEASUREMENT
Authors: Mruga D. O. , Dzyadevych S. V. , Soldatkin O. O.
Published: July 2022

In this work, an amperometric biosensor to determine ALT, which will be part of a biosensor system for simultaneous measurement of AST and ALT and their ratios, was developed. A platinum disk electrode was used as the electrochemical transducer. To form a bioselective element, a mixture based on glutamate oxidase was applied to the surface of transducer. A universal method for measuring ALT activity using the developed biosensor was proposed and described. During the study, the optimal concentrations of ALT substrates (α-ketoglutarate - 50 μM, alanine - 4 mM) and coenzyme (50 mkM of PLP) were selected. The analytical characteristics of the developed biosensor were also investigated, namely, sensitivity, linear range, minimum limit of determination, selectivity, stability, etc. It was shown the fundamental possibility of using this biosensor to measure the content of ALT in real samples.
Estudo da dinâmica de evacuação em caso de incêndio e pânico no Teatro Municipal de Nova Veneza – SC
Authors: Amboni Destro Helena , Cauduro Flávia
Published: July 2022

Os incêndios em construções podem acontecer de maneiras aleatórias e por esse motivo se tornam arriscados e agressivos. Além da preservação da edificação, é necessário o estudo da proteção das pessoas presentes no local, a fim de minimizar o risco à vida. O presente projeto teve como objetivo a análise e o estudo das condições de segurança de um teatro, localizado na cidade de Nova Veneza. Essa análise foi feita com o estudo de projeto baseado em desempenho, performance-based design, através de duas ferramentas computacionais. Uma fez a simulação do caminho da evacuação dos indivíduos presentes e a outra demonstrou a propagação da fumaça proveniente de um determinado incêndio. Através dos softwares foram extraídos dados e gráficos importantes para uma clara e dinâmica observação dos resultados. Com esses resultados obtidos foi possível analisar o quão segura está a edificação já construída e em quais aspectos ela poderia ser aprimorada para uma maior segurança caso viesse acontecer situações de emergência.
Análise da influência das juntas de assentamento na resistência a aderência do sistema de revestimento cerâmico de fachada
Authors: Wanderlind Augusto , Luiz Tamiris Lodetti , Antunes Elaine Guglielmi Pavei , Piva Jorge Henrique
Published: July 2022

Nos últimos anos houve um aumento significativo na utilização do revestimento cerâmicos em fachadas, devido às suas diversas vantagens comparado à outros tipos de revestimento. Entretanto, percebe-se que há falhas em alguns aspectos quando se trata de estudos relacionados ao desempenho dos componentes do revestimento cerâmico como sistema, metodologias de ensaios laboratoriais para avaliar sua degradação e definição da previsibilidade de vida útil. Entre as patologias mais frequentes nos sistemas de revestimentos cerâmicos de fachadas podemos citar o destacamento, que ocorre devido a sua exposição a vários fatores degradantes, como radiação, variações de temperatura e umidade. Dentre vários requisitos, a junta de assentamento é o componente responsável pelo alívio das tensões sobre o revestimento cerâmico. Deste modo, o presente estudo tem como objetivo analisar a influência das juntas de assentamento na resistência de aderência do sistema de revestimento cerâmico de fachadas, quando submetido a ensaios de envelhecimento acelerado. As amostras são compostas por substrato padronizado da ABCP, argamassa colante AC-III, placas cerâmicas BIIa e argamassa de rejuntamento Tipo II. As referidas amostras foram submetidas a 1994 ciclos higrotérmicos, com duração de 65 minutos cada. A variável avaliada é a espessura das juntas de assentamento, onde foram moldados painéis com junta de assentamento zero, juntas de 1,5 mm e juntas de 3 mm.
Proposta de solução para estrutura de contenção contra queda de rochas para um talude na Região Sul de Santa Catarina
Authors: Rocha Heliton Marcon , Steiner Luiz Renato
Published: July 2022

A queda de rochas e o rompimento de taludes são regidos por fatores geológicos, geomorfológicos, climáticos e pela ocupação irregular e ilegal de encostas. Há três classificações quanto ao movimento de terra causado pela instabilidade de maciços: desprendimento de terra ou rocha, escorregamento (landslide) e rastejo (creep). Além disso, as principais formas de ruptura de taludes rochosos são ruptura circular, planar, em cunha e tombamento de blocos (toppling). Há maneiras de evitar as rupturas de taludes por meio de estruturas de contenção, classificadas por proteções ativas e passivas, que devem atender a fatores de seguranças mínimos regidos pela ABNT NBR 11682/2009. O objetivo deste trabalho foi dimensionar uma estrutura de proteção contra quedas de rochas para o maciço estudado por Zorzi e Müller (2019). As autoras classificaram um maciço rochoso localizado no bairro Morro dos Conventos na Cidade de Araranguá, através do sistema RMR. O maciço, caracterizado em famílias, obteve classificação III e IV, apresentando grandes indícios de alteração e fraturamento. Através deste estudo, e das características do local, foi dimensionado uma estrutura de proteção contra queda de rochas baseado num sistema de malhas SteelGrid MO 200, com cabos de suporte de alma de aço de diâmetro de 12 mm ancorados à crista do talude por meio de barras de ancoragem de aço CA-50 de φ20 mm. A validação do dimensionamento foi feita por meio do software MacRO Studio v3.0. Concluiu-se que a estrutura dimensionada foi satisfatória, visto que apresentou fatores de segurança superiores ao mínimo estipulado pela ABNT NBR 11682/2009.
Índice de Concentração de chuva diária de Timbé do Sul, Santa Catarina
Authors: Back Álvaro José
Published: July 2022

A concentração de chuva em alguns períodos pode indicar maior risco de ocorrência de eventos como erosão, inundação e escorregamentos de encostas. O índice de Concentração de chuvas diárias tem sido empregado para avaliar a concentração da precipitação diária e também como indicador da erosividade e agressividade das chuvas. O objetivo deste trabalho foi determinar o Índice de concentração de chuvas para a região de Timbé do Sul, Santa Catarina. Foram utilizados os dados diários de precipitação do período de 1977 a 2020 da estação pluviométrica da Agência Nacional de Águas e Saneamento Básico, localizada no município de Timbé do Sul, Santa Catarina. Foram calculados os valores do índice de Concentração (IC) e a precipitação dos 25% (PP25) dos dias mais chuvosos, considerando a série total e também por trimestre e para cada mês. Os resultados mostraram que o IC anual é de 0,545, classificado com média concentração. Os 25% dos dias mais chuvosos representam 62% da precipitação total anual. Não foram observadas variações sazonais importantes nestes índices, concluindo-se que a precipitação da região tem homogeneidade sazonal na concentração
EDUCAÇÃO DE JOVENS E ADULTOS NA AMAZÔNIA RIBEIRINHA: A EXPERIÊNCIA DA ILHA XINGU, ABAETETUBA-PA
Authors: Silva Marlon Lima da , Barros Renato Carvalho
Published: July 2022

O artigo analisa e avalia experiências educacionais e administrativas da Educação de Jovens e Adultos (EJA) em comunidade ribeirinha na Amazônia brasileira. Para tanto, elege como recorte espacial a ilha Xingu, no município de Abaetetuba-PA. Os indicadores analíticos utilizados foram: entrevistas com os professores e gestores; estatística da evasão escolar entre os anos de 2001 e 2008; observações sistemáticas de trabalho de campo. Ao sistematizar os indicadores, mostra aspectos positivos do processo de alfabetização de jovens e adultos, mas, também, revela uma série de dificuldades operacionais e administrativas que perpassam pela falta de infraestrutura, evasão escolar e culminam com a descontinuidade das turmas da EJA em 2008. Ao final, conclui mostrando que a reativação da EJA se torna ainda mais estratégica na comunidade ribeirinha da ilha Xingu. Não apenas para possibilitar oportunidades reais de inclusão e melhoria da qualidade de vida, mas, também, para instrumentalizar movimentos de resistência em favor da defesa do modo vida e do ambiente natural amazônicos, ameaçados pela presença de grandes empreendimentos portuários.PALAVRAS CHAVE: Educação de Jovens e Adultos; Amazônia; ribeirinhos.
REPRESENTAÇÕES SOCIAIS DE ALUNOS DO ENSINO FUNDAMENTAL DE UMA ESCOLA PÚBLICA SOBRE PESQUISA COMO PRINCÍPIO EDUCATIVO
Authors: Nascimento Gabriele Felizardo Vianna do , Pereira Antonio Serafim
Published: July 2022

O presente trabalho, concebido no contexto do projeto PIBIC/UNESC, descreve o estudo investigativo que buscou compreender as representações sociais de alunos do Ensino Fundamental, anos finais, de uma escola pública municipal de um município catarinense sobre a pesquisa como princípio educativo. Os dados coletados foram obtidos por meio de entrevista semiestruturada, submetidos à análise de conteúdo e interpretados, especialmente, os concernentes à pesquisa, na interlocução com Beillerot (2001), Demo (2006, 2007), Freire (1999), Oliveira; Campello (2016), Teixeira (2011), entre outros. As representações sociais dos alunos sobre pesquisa pouco se coadunam com os critérios básicos que demanda. Isto porque, segundo os participantes do estudo, as atividades de aula estão mais presas a exercícios com respostas reprodutivas, decorrentes de cópia e uso do livro didático/apostila, inclusive, atribuição e quantificação de nota. Pode se dizer, que a alusão à pesquisa como possibilidade de aprender mais restringiu-se à menção, por assim dizer, de pouco realce. PALAVRAS-CHAVE: Pesquisa. Representações Sociais. Alunos. Ensino Fundamenta
FORMAÇÃO HUMANA E OS NOVOS DESAFIOS DA EDUCAÇÃO À LUZ DA SOCIEDADE DO ESPETÁCULO
Authors: Machado Damila , Souza Karine da Silva de , Mueller Rafael Rodrigo
Published: July 2022

RESUMO: O presente trabalho tem como objeto de análise a formação humana sob a perspectiva da Internacional Situacionista (IS). Objetiva-se expor a relação entre formação humana a partir do conceito de Sociedade do Espetáculo, centrando o estudo na obra de mesmo nome do intelectual francês Guy Debord (1931-1994), tendo o conceito de espetáculo como base fundamental para o entendimento da estrutura de vida cotidiana do século XXI. A base para o procedimento metodológico da presente pesquisa é o materialismo histórico-dialético, considerando-se para tal, a perspectiva ontológica de constituição do ser humano. Dentre os diagnósticos relacionados à pesquisa, identificamos que os processos educativos veiculados por meio de sites como o YouTube estão entre as variadas formas da espetacularização da vida, o que torna a educação um objeto de troca e a insere em segundo plano visando, na maioria das vezes, o lucro e não a formação humana integral. PALAVRAS-CHAVE: Espetáculo. Capitalismo atencional. Edutubers.
A NATUREZA COMO POSSIBILIDADE DE BRINCAR, CRIAR E IMAGINAR NA EDUCAÇÃO INFANTIL: AS ABORDAGENS DE REGGIO EMÍLIA E GANDHY PIORSKI
Authors: Martins Joice Peres , Camargo Gislene
Published: July 2022

RESUMO: A imaginação e a criatividade podem ser desenvolvidas na Educação Infantil por meio do brincar. Portanto, a escolha do tema dessa pesquisa, se deu devido às observações feitas em instituições de Educação Infantil, onde as crianças tinham brinquedos à sua disposição, mas preferiam os potes, gravetos, pedras e as folhas espalhadas pelo parque. Durante a graduação, vimos abordagens que desenvolvem seu processo didático-pedagógico baseadas nos elementos naturais, o que instigou a elaboração do problema da pesquisa: Quais as possibilidades que os elementos naturais, podem oferecer para o desenvolvimento da imaginação e da criatividade na Educação Infantil? Buscou-se como objetivo geral, compreender as possibilidades que os elementos naturais oferecem para o desenvolvimento da imaginação e da criatividade das crianças. A metodologia aplicada à pesquisa foi a bibliográfica, com abordagem qualitativa. Com base nos autores Vygotsky (2014), Rinaldi (2014), Barbosa; Horn, (2008), Louro (2013), Piorski (2016), entre outros, desenvolveu-se a pesquisa bibliográfica. Por fim, concluiu-se que a Educação Infantil necessita possibilitar espaços diferenciados, sair das salas de referências e ir para o gramado, para a areia, pisar nos pedriscos, desafiar a criança a pensar, imaginar e criar por meio de suas sensações e ainda criar para si e para o grupo, referências afetivas. Ter o contato com a natureza e sentir-se parte dela, contribui para a preservação do ambiente e da vida. PALAVRAS CHAVE: Educação Infantil. Brincar. Natureza. Imaginação e criatividade.
Simultaneous endovascular "edge-to-edge" clipping of the mitral valve leaflets and closure of the left atrial appendage in a high surgical risk patient
Authors: Semitko Sergey P. , Asadov Dzhamil A. , Rogatova Anna N. , Stepanov Alexander V. , Mesyats Natalya S. , Pak Natalya L. , Sandodze Tamara S. , Fomenko Viktoria V. , Kamolov Imomali K. , Pankov Andrey N. , Zakharova Olga V. , Azarov Alexey V. , Chernysheva Irina E. , Ioseliani David G.
Published: July 2022

Mitral regurgitation is one of the most common valvular heart diseases, with the gold standard of its treatment being an open surgical intervention. However, it is not always performed in patients with a high surgical risk. Atrial fibrillation is a frequent companion of mitral valve regurgitation. It significantly increases the risk of ischemic strokes and systemic thromboembolism and required the administration of anticoagulants. Long-term use of anticoagulants entails an increased risk of hemorrhagic complications. Surgical endovascular closure of the left atrial appendage allows for reduction of the risks both of embolic and hemorrhagic complications.
This paper presents a clinical case of the first in Russia successful simultaneous endovascular remodeling of the mitral valve by edge-to-edge leaflet clipping and closure of the left atrial appendage with an Amplatzer Amulet occluder. This was an 85-year old patient with advanced mitral regurgitation, who was not considered a candidate for an open surgery due to his high surgical risk. The severity of the patients condition was related to atrial fibrillation, rectal cancer and severe anemia. The patient underwent simultaneous sequential clipping of the mitral valve leaflets and closure of the left atrial appendage. Control trans-esophageal echocardiography showed a significant decrease in the mitral regurgitation grade. There were no complications during the hospital stay and in the early postoperative period.
The lack of convincing data and research makes it impossible to delineate clear indications and contraindications for the combination of two procedures within one surgical session. However, simultaneous endovascular clipping of the mitral valve leaflets and an occluder implantation into the left atrial appendage may become the method of choice in the treatment of patients with severe mitral valve regurgitation, prevention of embolic and hemorrhagic complications in high risk comorbid patients.
Targeted treatment with somatostatin analogues: widening horizons of clinical practice
Authors: Pronin Vyacheslav S. , Antsiferov Mikhail B. , Alexeeva Tatiana M. , Pronin Evgeny V.
Published: July 2022

Targeted treatment with somatostatin analogues (SA) in acromegaly and neuroendocrine neoplasms may have some benefits compared to curative treatments, because these agents decrease excessive hormone secretion and exert a tumor-suppressive effect. Monotherapy and combination therapy with SA is well tolerated and bears no risk of debilitating iatrogenic complications. In acromegaly caused by somatotropin producing pituitary tumor, first generation SA are treatment of choice after non-radical adenomectomy, as well as in the cases when patients reject surgery. Treatment efficacy depends on the pathomorphological types of somatotropic tumors, which are different in their receptor phenotype, clinical scenario and proliferative activity. The first generation SA are successfully used for medical treatment of other pituitary tumors (thyrotropic, corticotropic, gonadotropic, lactotropic with resistance to dopamine agonists), as well as for adjuvant therapy of neuroendocrine and non-endocrine neoplasms and elimination of various gastrointestinal disorders. The anti-secretory and anti-tumor effects of SA have been proven for gastroenteropancreatic tumors (carcinoid syndrome, vipomas, gastrinomas, insulinomas, glucagonomas, somatostatinomas). Targeted selection of patients for treatment with first generation SA based on the receptor phenotypes of malignant cells would facilitate more rapid achievement of biochemical remission, improvement of quality of life and survival.
Developments in on-animal sensors for monitoring livestock
Authors:   CQUniversity Institute for Future Farming Systems, Australia, Trotter Mark , Bailey Derek ,   New Mexico State University, USA, Manning Jaime ,   CQ University Institute for Future Farming Systems, Australia, Evans Caitlin ,   CQ University Institute for Future Farming Systems, Australia, Costa Diogo ,   CQ University Institute for Future Farming Systems, Australia, Fogarty Elle ,   CQ University Institute for Future Farming Systems, Australia, Chang Anita ,   CQ University Institute for Future Farming Systems, Australia
Published: July 2022

This chapter introduces the concept and history of development of on-animal sensors. It explores the different components that make up these systems and the various challenges and limitations that are faced by developers seeking to operationalize these on commercial livestock farms. The specific sensor systems that have been explored over the years are reviewed and the various applications that can be achieved by using them will be introduced.
Machine vision techniques to monitor behaviour and health in precision livestock farming
Authors:   University of Catania, Italy, Arcidiacono C. , Porto S. M. C. ,   University of Catania, Italy
Published: July 2022

This chapter reviews advances in computer vision-based technologies for precision livestock farming. It also reviews how automation in image analysis can promote smart management of livestock to improve health and welfare. The chapter discusses the main devices for data acquisition in computer-vision based systems and the range of tasks computer vision (CV) techniques can perform. It reviews key steps such as initialisation, tracking, pose detection and recognition. The chapter includes illustrative case studies of precision livestock farming (PLF) applications based on existing CV techniques. The chapter concludes by reviewing recent advances in CV techniques based on artificial neural network (ANN) techniques, as well as future challenges.
Developments in individual-animal feed efficiency monitoring systems for livestock
Authors:   The Volcani Centre - Agriculture Research Organization (ARO), Israel, Halachmi Ilan ,   Ben-Gurion University of the Negev, Israel, Bezen Ran ,   The Volcani Centre - Agriculture Research Organization (ARO), Israel,   Ben-Gurion University of the Negev, Israel, Godo Assaf ,   The Volcani Centre - Agriculture Research Organization (ARO), Israel, Levit Harel ,   The Volcani Centre - Agriculture Research Organization (ARO), Israel, Bloch Victor ,   The Volcani Centre - Agriculture Research Organization (ARO), Israel, Edan Yael ,   Ben-Gurion University of the Negev, Israel
Published: July 2022

Feed remains a major cost in livestock farming. Accurate measurement of feed intake by individual animals offers the possibility of significant savings and more efficient production. The use of advanced low-cost cameras and innovative computer vision algorithms is changing feed-intake monitoring system design. With the help of these technologies, individual feed intake measurement (IFIM) systems will become available to farmers, replacing expensive and less accurate mechanical weighing systems. Based on a literature review of key recent studies, this chapter describes the sensors and algorithms employed in different individual feed intake measurement systems for dairy cows.
Bivariate Weibull-G Family Based on Copula Function: Properties, Bayesian and non-Bayesian Estimation and Applications
Authors: El-Sherpieny El-Sayed A. , Almetwally Ehab M. , Muhammed Hiba Z.
Published: July 2022

This paper aims to obtain a new flexible bivariate generalized family of distributions based on FGM copula, which is called bivariate FGM Weibull-G family. Some of its statistical properties are studied as marginal distributions, product moments, and moment generating functions. Some dependence measures as Kendall’s tau and median regression model are discussed. After introducing the general class, four special sub models of the new family are introduced by taking the baseline distributions as Pareto, inverted Topp-Leone, exponential, and Rayleigh distributions. Maximum likelihood and Bayesian approaches are used to estimate the model unknown parameters. Further, percentile bootstrap confidence interval and bootstrap-t confidence interval are estimated for the model’s parameters. A Monte-Carlo simulation study is carried out of the maximum likelihood and Bayesian estimators. Finally, we illustrate the importance of the proposed bivariate family using two real data sets in medical field.
The Odd Log-Logistic Transmuted-G Family of Distributions: Properties, Characterization, Applications and Different Methods of Estimation
Authors: Alizadeh Morad , Rasekhi Mahdi , Yousof Haitham M. , Hamedani G.G. , Ataei Alireza
Published: July 2022

In this work, we propose a new class of lifetime distributions called the odd log-logistic transmuted-G family. The proposed family of distributions is constructed by compounding the odd log-logistic distribution with the transmuted distribution. It can provide better fits than some of the known lifetime models and this fact represents a good characterization of this new family. Some characterizations for the new family are presented as well as some of its mathematical properties including. The maximum likelihood, Least squares and weighted least squares, Cram\'{e}r--von--Mises, Anderson-Darling and right-tailed Anderson-Darlingare and maximum product of spacings methods are used for estimating the model parameters. The importance and flexibility of the new family are illustrated by means of an application to a real data set.
Statistical Inference for Multivariate Conditional Cumulative Distribution Function Estimation By Stochastic Approximation Method
Authors: Slama Sahar , Slaoui Yousri , Fathallah Hamdi
Published: July 2022

This paper handles non-parametric estimation of a conditional cumulative distribution function (CCDF). Using a recursive approach, we set forward a multivariate recursive estimator defifined by stochastic approximation algorithm. Our basic objective is to investigate the statistical inference of our estimator and compare it with that of non-recursive Nadaraya-Watson’s estimator. From this perspective, we fifirst derive the asymptotic properties of the proposed estimator which highly depend on the choice of two parameters, the stepsize (γn) as well as the bandwidth (hn). The second generation plug-in method, a method of bandwidth selection minimizing the Mean Weighted Integrated Squared Error (MW ISE) of the estimator in reference, entails the optimal choice of the bandwidth and therefore maintains an appropriate choice of the stepsize parameter. Basically, we demonstrate that, under some conditions, the Mean Squared Error (MSE) of the proposed estimator can be smaller than the one of Nadaraya Watson’s estimator. We corroborate our theoretical results through simulation studies and two real dataset applications, namely the Insurance Company Benchmark (COIL 2000) dataset as well as the French Hospital Data of COVID-19 epidemic.
On Sensitivity for Portfolio Optimisation Based on a High-dimensional Jump-diffusion Merton Model
Authors: AFHAMI BAHAREH , Rezapour Mohsen , Madadi Mohsen , Maroufy Vahed
Published: July 2022

The problem of singularity of the variance-covariance matrix and its impact on the sensitivity of Markowitz portfolio optimization has been extensively studied in the literature when the underlying model does not include jump terms. In this paper, we first use a jump-diffusion multivariate Merton model to evaluate sensitivity of portfolio optimization and apply principal component analysis (PCA) for dimensionality reduction as a solution to singularity of the variance-covariance matrix. Finally, we provide a numerical study based on the adjusted daily closing price of $S\&{P}\, 500$ stocks to explore the impact of the dimension of the reduced space and jump terms on the sensitivity of the portfolio optimization. Empirical experiments confirm that for models without jump terms, the sensitivity analysis may not reflect the correct assessment of the impact of dimensionality reduction on the portfolio optimization.
The Distribution of Roof Tiles in Island Areas in the Goryeo Dynasty - Focusing on roof tiles excavated from Heuksan Island -
Authors:   Central Institute of Cultural Heritage, Lee Su-Kyung
Published: July 2022

Heuksando Island is the first stop in Goryeo, which starts in southeastern China and reaches the fastest, and occupies a very important location as a mid-range hub. It served as an important maritime gateway connecting Korea, China, and Japan, including Song Dynasty diplomacy during the Goryeo Dynasty.
The relics unearthed from the of government office site and A temple called Musimsa, excavated from Heuksando, are all high-quality celadon, Chinese porcelain, and roof tiles, suggesting the status of Heuksando during the Goryeo Dynasty.
In this paper, the relationship between the inflow of tiles from the islands of the Goryeo Dynasty was examined, focusing on the tiles excavated from Heuksando Island.
The roof tiles of Heuksando Island are divided into two periods. The first period was when prestigious tiles were produced and used, and inland places such as Hwasun, Naju, Gwangju, and Damyang were confirmed in tiles. Among them, the tile with the inscription "Nungseong-gun" is an old place name of Hwasun, and has been confirmed not only in Heuksando Island but also in the ruins of Hwasun area. One tile pattern excavated from the ruins of Jamjeong-ri, Hwasun, was also excavated from the roof tiles of the site of the government office. In addition, the similarity of the production sites between the two regions was confirmed through the analysis of the clay of roof tiles.
The second period is the central period of Heuksando Island, and the shape of the roof-end tile has a hemispherical protrusion in the center, and the shape of the two rows around it is not confirmed, but only the deformed hemispherical protrusion-shaped roof-end tile is confirmed. The excavated "Ilhwamun" and "Dangchomun" set roof-end tile and "Yeonhwamun" roof-end tile have been confirmed to be related to the inland areas of Jeollanam-do.
The reason why prestigious tiles with inland names were excavated in Heuksando Island is that it is estimated that there was a limit to the production of its own tiles due to the specificity of the island. In addition, the area identified in the place name is related to Jochang, a Jounje system of the Goryeo Dynasty, and is a flush area of Haereungchang, Naju, one of the six Jochangs in Jeolla-do. In addition, it is estimated that a distribution system was established in which tiles made in Hwasun, Damyang, and Gwangju were transported to Naju, where the residents of Heuksando Island moved to Haereungchang, Naju.
Recomendações sobre a Abordagem da Esclerose Múltipla na Gravidez, Parto e Pós-Parto: Posição de Consenso do Grupo de Estudos de Esclerose Múltipla
Authors: Batista Sónia , Martins da Silva Ana , Sá Maria José , Sousa Lívia , De Sá João , Pedrosa Rui , Cerqueira João , Pinheiro Joaquim , Abreu Pedro , Simões Rita Moiron , Vale José
Published: July 2022

A esclerose múltipla afecta tipicamente mulheres jovens em idade reprodutiva. Desta forma, todo os profissionais de saúde envolvidos no seguimento destes doentes deverão estar preparados para abordar as questões relacionadas com a gravidez e amamentação e fornecer o melhor aconselhamento possível. No entanto, existem ainda muitas dúvidas e abordagens clínicas heterogéneas em parte devido à ausência de consensos e normas orientadoras. No que concerne ao manuseamento das terapêuticas modificadoras de doença durante os períodos de gravidez e pós-parto, as incertezas têm sido agravadas devido ao aumento do número de fármacos disponíveis nos últimos anos. Este artigo visa apresentar a informação mais atual e fornecer orientações baseadas no melhor nível de evidência disponível e na opinião de peritos relativamente ao seguimento das doentes com esclerose múltipla em diferentes etapas: planificação da gravidez, gravidez, parto e período pós-parto.
Polifarmácia e Utilização de Medicação Potencialmente Inapropriada no Idoso com Idade Igual ou Superior a 75 Anos: O Caso de uma Unidade de Saúde Familiar
Authors: Castilho Inês , Rocha Érica , Magalhães Sara , Vaz Zélia , Costa Ana Lúcia Gomes
Published: July 2022

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Telemedicine Yes, But No Telepathy
Authors: López Reboiro Manuel Lorenzo , Sardiña González Cristina , Castro-Conde Beatriz Ares , López Castro José
Published: July 2022

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Existe um Papel para a Psiquiatria no Processo de Morte Assistida em Portugal?
Authors: Barranha Rui
Published: July 2022

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Life-Threatening Wunderlich Syndrome Associated with Apixaban and the Complexity of Anticoagulation Management in Bleeding Patients: A Case Report
Authors: Maltês Sérgio , Carvalho Gouveia Cristina , Serrazina Filipa , Rebelo Marta
Published: July 2022

Wunderlich syndrome is a rare and possibly life-threatening haemorrhagic syndrome presenting as spontaneous nontraumatic renal rupture with subcapsular and perinephric haemorrhage. Apixaban, a direct oral anticoagulant recommended in patients with atrial fibrillation, has previously been associated with atraumatic solid organ rupture but, to date, no case of apixaban-related Wunderlich syndrome has been reported. We report a rare case of Wunderlich syndrome associated with apixaban while addressing the difficulties face by clinicians when managing anticoagulation in bleeding patients.
A Case Report of Acute Hepatitis of Unknown Origin
Authors: Cardoso Leonor , Vieira Martins Miguel , Lima Sofia , Carvalho Cristiana , Jorge Arminda
Published: July 2022

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The Addition of Caulerpa racemosa Extract in Feed on Clinical Sign and Intestinal Histopathological Profile of Whiteleg Shrimp after Infected by Vibrio parahaemolyticus
Authors: Pratiwi Alvira Febrianti , Satyantini Woro Hastuti , Mahasri Gunanti , Mukti Akhmad Taufiq , Isnansetyo Alim
Published: July 2022

The purpose of this study was to determine the administration of Caulerpa racemosa extract in clinical sign and intestinal histopathological profile of whiteleg shrimp (Litopenaeus vannamei) after infected by Vibrio parahaemolyticus. The study was conducted using a completely randomized design (CRD) with six treatments and three replications. Shrimp were divided into six groups, two control groups without the administration of C. racemosa extract, the other four groups with the administration of C. racemosa extract with successive doses; 30 mg/kg (P1), 60 mg/kg (P2), 120 mg/kg (P3) and 240 mg/kg (P4) through feed. On the 15th day of rearing, the control group was divided into two groups: negative control (K-) was injected with PBS and then positive control (K+) and four other treatments (P1, P2, P3 and P4) were infected with V. parahaemolyticus. The results showed that intestinal damage caused by V. parahaemolyticus infection were inflammation and necrosis. The administration of C. racemosa extract had a significant effect on the histopathological profile of the whiteleg shrimp intestine. The lowest percentage of damage was found in the P4 treatment, which was 19.6% with a indication of low damage. Clinical sigs appeared at 48 hours post-infection pale hepatopancreas, empty intestines, reddened uropods and gnats. From this study, it can be concluded that the administration of C. racemosa extract to the feed at a dose of 240 mg/kg is the best dose in reducing the level of damage to the intestinal organs of whiteleg shrimp infected with V. parahaemolyticus.
Analysis of the Impact of the COVID-19 Pandemic on Lobster Cultivation Activities (Panulirus spp.) in East Lombok Regency
Authors: Subhan Mohammad , Junaidi Junaidi
Published: July 2022

The COVID-19 pandemic has caused lobster cultivators (Panulirus spp.) in East Lombok Regency to try to fulfill their daily needs by looking for other jobs. The purpose of this study was to determine the impact of the COVID-19 pandemic on the sustainability of the lobster cultivation business in East Lombok Regency. The research method used was descriptive qualitative method based on the data generated during the research. Analysis of the data used in this research was the Net Benefit Cost Ratio to determine the amount of net profit from costs and investments. Stakeholder perceptions were analyzed descriptively. The results of the analysis show that the lobster cultivation business is still feasible to do, so it can be concluded that the COVID-19 pandemic has no impact on the sustainability of the lobster cultivation business in East Lombok Regency. To maintain the continuity of lobster cultivation in East Lombok Regency, it is necessary to ensure the availability of feed and guarantee access to marketing.
Tilapia (Oreochromis niloticus) Farming In Buckets In Sakatiga Village, Indralaya District, Ogan Ilir Regency
Authors: Saputra Edo , Mukti Retno Cahya , Amin Mohamad , Jubaedah Dade , Yulisman Yulisman , Rarassari Madyasta Anggana
Published: July 2022

Currently, the problem of increasingly limited land availability has led to increasingly limited cultivation activities. The decreasing number of large cultivation locations requires people to be more creative in utilizing narrow locations and in saving water. Fish farming in buckets is a potential solution for aquaculture in a narrow area with more efficient use of water, easy for the community to do in their respective homes with relatively small capital, and finally able to meet the nutritional needs of the community. The purpose of this study was to determine the growth of tilapia (Oreochromis niloticus) kept in buckets using water spinach plants (Ipomoea aquatica). This research used two treatments, namely P0: control (fish farming in buckets without using plants) and P1: fish farming in buckets using plants. Parameters observed were absolute weight growth, absolute length growth, feed efficiency, and survival. The results showed that the P1 treatment resulted in an absolute weight growth of 3.44 g, an absolute length growth of 1.12 cm, feed efficiency of 93.08%, and survival of 100%. While the P0 treatment resulted in absolute weight growth of 3.92 g, absolute length growth of 1.21 cm, feed efficiency 81.75 %, and survival of 82.5%. Rearing tilapia in buckets without water spinach plants better results than using water spinach plants.
A nano-enhanced vaccine for metastatic melanoma immunotherapy
Authors: Salotto Katelyn E. , Olson Jr Walter C. , Pollack Karlyn E. , Illendula Anuradha , Michel Elishama , Henriques Sydney , Fox Todd , Walker Susan , Dunlap-Brown Marya , Slingluff Jr Craig L. , Kester Mark , Snyder Helena W.
Published: July 2022

Aim: Despite the huge advancements in cancer therapies and treatments over the past decade, most patients with metastasized melanoma still die from the disease. This poor prognosis largely results from resistance to conventional chemotherapies and other cytotoxic drugs. We have previously identified 6 antigenic peptides derived from melanomas that have proven efficacious for activating CD4+ T cells in clinical trials for melanoma. Our aim was to improve pharmacodynamics, pharmacokinetic and toxicological parameters by individually encapsulating each of the 6 melanoma helper peptides within their own immunogenic nanoliposomes. Methods: We modified these liposomes as necessary to account for differences in the peptides’ chemical properties, resulting in 3 distinct formulations. To further enhance immunogenicity, we also incorporated KDO2, a TLR4 agonist, into the lipid bilayer of all nanoliposome formulations. We then conducted in vivo imaging studies in mice and ex vivo cell studies from 2 patient samples who both strongly expressed one of the identified peptides. Results: We demonstrate that these liposomes, loaded with the different melanoma helper peptides, can be readily mixed together and simultaneously delivered without toxicity in vivo. These liposomes are capable of being diffused to the secondary lymphoid organs very quickly and for at least 6 days. In addition, we show that these immunogenic liposomes enhance immune responses to specific peptides ex vivo. Conclusion: Lipid-based delivery systems, including nanoliposomes and lipid nanoparticles, have now been validated for pharmacological (small molecules, bioactive lipids) and molecular (mRNA, siRNA) therapeutic approaches. However, the utility of these formulations as cancer vaccines, delivering antigenic peptides, has not yet achieved the same degree of commercial success. Here, we describe the novel and successful development of a nanoliposome-based cancer vaccine for melanoma. These vaccines help to circumvent drug resistance by increasing a patient’s T cell response, making them more susceptible to checkpoint blockade therapy.