bluuebunny/crossref_metadata_2025 huggingface dataset:
Early progression of a pancreatic metastasis of synovial sarcoma after pancreatectomy
Authors: Okazaki Mitsuyoshi , Katano Kaoru , Sugita Hiroaki , Tokoro Tomokazu , Gabata Ryousuke , Takada Satoshi , Nakanuma Shinichi , Makino Isamu , Yagi Shintaro
Published: February 2023

Background

Synovial sarcoma is a malignant tumor that constitutes up to 10% of all soft-tissue sarcomas. The most frequent metastatic sites of synovial sarcoma are the lungs, lymph nodes, and bone, whereas pancreatic metastasis is extremely rare. Here, we report a case of pancreatic metastasis of synovial sarcoma.

Case presentation

Nine years before presentation, a 31-year-old woman underwent extensive resection of the primary tumor after chemotherapy for left upper extremity synovial sarcoma. Six months before presentation, interscapulothoracic amputation was performed for an enlarged mass in the left upper extremity; the patient was treated with pazopanib. Three months before presentation, chest computed tomography showed multiple lung metastases; during subsequent follow-up, abdominal computed tomography revealed a pancreatic metastasis of synovial sarcoma. The doubling time of the pancreatic tumor was 14 days, and it grew rapidly. Furthermore, treatment-resistant pancreatitis symptoms were detected; thus, we performed distal pancreatectomy and administered one course of a 70% dose of trabectedin. However, the patient died of rapid progression of lung metastasis and respiratory failure within 2 months after surgery.

Conclusions

Pancreatectomy may be carefully performed in cases of isolated pancreatic metastasis. However, the presence of other distant extrapancreatic metastases (e.g., uncontrolled lung metastases) may rule out pancreatectomy treatment.
A window of opportunity trial evaluating intratumoral injection of Copaxone® in patients with percutaneously accessible tumors
Authors: Baranda Joaquina C. , Mohyuddin Ghulam Rehman , Bur Andrés M. , Shnayder Yelizaveta , Sweeney Kyle R. , Kakarala Kiran , Prouty Megan , Pathak Harsh , Puri Rajni , Mitra Amrita , Madan Rashna , Forrest M. Laird , Huang Aric , Weir Scott , Godwin Andrew K. , Alhakamy Nabil A. , Griffin J. Daniel , Berkland Cory J.
Published: February 2023

Background

This window of opportunity trial evaluated the safety of intratumoral Copaxone® and profiled immune markers in biopsies before and after treatment.

Methods

Patients with percutaneously accessible malignancies scheduled for surgical resection with curative intent were eligible to participate. Adverse events from one, two, or three injections of Copaxone® were monitored leading up to surgical resection. Using RNA sequencing and spatial protein profiling of immune-related targets, changes in mRNA and protein expression patterns, respectively were assessed in tumor biopsy samples pre- and post-treatment.

Results

Adverse events at the injection site were mild and consistent with historic subcutaneous administration of Copaxone®. Increased intratumoral immune activity was evident in most patients, including the upregulation of genes associated with immune stimulation and targets of checkpoint inhibitor therapy.

Conclusions

Intratumoral injection of Copaxone® was well tolerated, and immune profile changes in the tumor microenvironment warrant its further evaluation as human intratumoral immunotherapy.

Trial registration

clinicaltrials.gov, NCT03982212 First posted June 11th,
2019
Is post-transplant day + 14 immature reticulocyte fraction (IRF) a reliable surrogate marker for predicting early platelet engraftment in pediatric hematopoietic stem cell transplant?
Authors: Ghias Zainab , Zaidi Uzma , Borhany Munira , Samad Shafaq Abdul , Durrani Noureen , Fatima Mushkbar , Zafar Sidra , Jamal Aisha , Shamsi Tahir
Published: February 2023

Background

Prophylactic platelet transfusion is given to patients when the platelet count is less than ten thousand to prevent clinically significant bleeding till platelet engraftment is documented. Despite a very low platelet count, if platelet engraftment is confidently predicted, then platelet transfusion can be avoided in an otherwise stable patient.

Objective

To determine the role of post-transplant day + 14 immature reticulocyte fraction (IRF) and immature platelet fraction (IPF) as surrogate markers for early prediction of platelet engraftment in pediatric hematopoietic stem cell transplant patients.

Material and methods

This prospective study was done at the National Institute of Blood Diseases and Bone Marrow Transplantation between January 2017 and December 2020. A total of 56 and 31 patients were enrolled in the deviation and validation cohorts respectively. IPF and IRF were tested on a Sysmex XN-1000 hematology analyzer on days + 14 and + 21 of the bone marrow transplant. Platelet count on day + 14 and the day of engraftment was documented. Spearman correlation analysis and receiver operating characteristic curve (ROC) calculation were done using the statistical package STATA version 12, to determine IRF and IPF cut-off values to predict a median platelet engraftment day.

Results

The derivation and validation cohorts were statistically comparable. The area under the receiver operating characteristic curve (ROC) for IPF and IRF was 0.53 (95% CI: 0.37 – 0.68, p = 0.750) and 0.74 (95% CI: 0.61 – 0.89, p = 0.001) respectively. A weak inverse correlation (rs0.36, p = 0.007) between IRF and platelet engraftment day was found. The ROC demonstrated that the cut-off value for Day + 14 IRF of 13% has a sensitivity and specificity of 92.9% and 37% respectively. This finding was confirmed in the validation group with sensitivity and specificity of 88.2% and 45.2% respectively.

Conclusion

This study found that Day + 14 IRF but not IPF value can reliably predict platelet engraftment by day + 17 post-transplant.
Probabilistic seismic petrophysical inversion with statistical double-porosity Biot-Rayleigh model
Authors: Luo Cong , Ba Jing , Guo Qiang
Published: February 2023

Petrophysical inversion quantitatively extracts reservoir properties from seismic data/attributes, which has gained increasing attention in assisting hydrocarbon reservoir exploration and evaluation. However, given complex reservoirs, its application is limited either due to the adopted rock-physics model or due to the computational demand. We have developed a semianalytic seismic petrophysical inversion method intended for complex reservoirs. The method incorporates the double-porosity Biot-Rayleigh (BR) model into the petrophysical forward operator, to take into account the heterogeneities within reservoir rocks. The inversion process combines statistical rock-physics modeling and Bayesian Gaussian mixture estimation, by which the analytical expression of the results can be achieved with limited computational cost. To better describe pore structure complexities, the inclusion content that constitutes a double-porosity medium of the BR model is considered an unknown variable, which favors the spatial variation of pore structures under complex lithofacies conditions. In addition, the method uses simulated annealing to estimate the inclusion content at a well location to obtain its prior information and takes advantage of the Monte Carlo simulation in rock-physics modeling to stabilize the inversion results. The method is tested and applied to the field data from a carbonate reservoir in southern China, the results of which show that the accuracy of the petrophysical parameters in terms of root-mean-square error are increased by as much as 12% compared with the method based on the Gassmann model.
The Association and Joint Effect of Adipocyte Fatty Acid Binding Protein and Obesity Phenotype With Cardiovascular Events
Authors: Hu Tingting , Shen Yun , Cao Weijie , Xu Yiting , Wang Yufei , Bao Yuqian , Ma Xiaojing
Published: February 2023

Context

There is little evidence regarding the joint effect of serum adipocyte fatty acid binding protein (A-FABP) levels and obesity phenotype on the risk of cardiovascular events.

Objective

To explore the association between serum A-FABP levels and obesity phenotype defined by fat percentage (fat%) and visceral fat area (VFA), and their joint impact on incident cardiovascular events.

Methods

A total of 1345 residents (579 men and 766 women) without previous cardiovascular diseases at baseline, with body composition and serum A-FABP data available, were included. A bioelectrical impedance analyzer and magnetic resonance imaging were used to assess fat% and VFA, respectively.

Results

During a mean follow-up of 7.6 years, 136 cases of cardiovascular events (13.9 per 1000 person-years) occurred. Per 1-unit increase in loge-transformed A-FABP levels was associated with an increase in cardiovascular events risk (hazard ratio [HR] 1.87, 95% CI 1.33-2.63). The highest tertiles of fat% and VFA levels were related to higher risks of cardiovascular events (fat%: HR 2.38, 95% CI 1.49-3.81; VFA: HR 1.79, 95% CI 1.09-2.93). The association between A-FABP levels and cardiovascular events was more pronounced in participants with low fat%, regardless of VFA levels. The joint effect of high A-FABP levels and obesity resulted in a greater risk of cardiovascular events.

Conclusion

Serum A-FABP levels were significantly associated with the risk of cardiovascular events, and this pattern of association was more prominent among the population with low fat%, which was independent of VFA.
Archaeologies of the Body: Imagining Abortion Care with Feminist Acompañantes in Mexico
Authors: Krauss Amy
Published: February 2023

This essay considers abortion politics as a struggle over our collective conditions of life and death. It brings the perspectives of feminist acompañantes in Mexico City and Xalapa, Veracruz, to bear on critical questions about forms of life, loss, care, and time. Although abortion is legal during the first twelve weeks of pregnancy in Mexico City and now in eight other states across the country, a powerful and diffuse feminist movement continues to grow adjacent to the law, building an autonomous sphere of collective practice. Within this movement, acompañantes—or abortion doulas—are creating an anticapitalist ethics of care and a political vocabulary that grapples with how to imagine futures amid proximity to death.
Isolating Personal Knowledge Spillovers: Coinventor Deaths and Spatial Citation Differentials
Authors: Balsmeier Benjamin , Fleming Lee , Lück Sonja
Published: February 2023

We propose a new method to estimate and isolate the localization of knowledge spillovers due to the physical presence of a person, using after-application but pre-grant deaths of differently located coinventors of the same patent. The approach estimates the differences in local citations between the deceased and still-living inventors at increasingly distant radii. Patents receive 26 percent fewer citations from within a radius of 20 miles around the deceased, relative to still-living coinventors. Differences attenuate with time and distance, are stronger when still-living coinventors live farther from the deceased, and hold for a subsample of possibly premature deaths. (JEL O31, O33, O34, R32)
Macroeconomic Dynamics with Rigid Wage Contracts
Authors: Broer Tobias , Harmenberg Karl , Krusell Per , Öberg Erik
Published: February 2023

We adapt the wage contracting structure in Chari (1983) to a dynamic, balanced-growth setting with recontracting as in Calvo (1983). The resulting wage-rigidity framework dampens income effects in the short run, thus allowing significant responses of hours to aggregate shocks. In reduced form, the model dynamics are similar to that in Jaimovich and Rebelo (2009), with their habit parameter replaced by our probability of wage-contract resetting. That is, if wage contracts are reset frequently, labor supply behaves in accordance with King, Plosser, and Rebelo (1988) preferences, whereas if they are never reset, we obtain the setting in Greenwood, Hercowitz, and Huffman (1988). (JEL E24, J22, J23, J24, J31, J41)
The Development of the Real Sector As the Basic Factor of the Sustainability of Regional Economic Systems
Authors: Kemaev K. , Kemaeva M. , Grinevich Yuliya
Published: February 2023

The development of modern regional economic systems is determined by many factors, the main of which are formed in the real sector of the economy. Considering the volume of output of economic goods and the structure of their redistribution between sectors of the economy as the basic indicator of production activity, the article proposes the use of value added redistributed to the real sector of the economy as an indicator of the level of development of regional economic systems characterizing their stability. The article provides a justification for the expediency of using indicators of the functioning of the real sector in each Russian region to assess the type of dynamics of territorial development, and also presents an original approach to normalizing the level of development of Russian regions. The normalization of the indicators of the economic dynamics of the regions was carried out using regression analysis methods and involves regular updating of values over time.
The Main Reasons for the Change in the Assortment of Manufacturing Enterprises in the Russian Federation in 2020–2022
Authors: Levkina Nataliya
Published: February 2023

In the period 2020–2022, all domestic enterprises experienced the consequences of the Covid-19 pandemic, changes in the geopolitical situation in the country and the world. In order to get the maximum result in rapidly changing economic conditions, enterprises demonstrate various strategies for managing individual aspects of their activities. This work is devoted to identifying the main reasons for the change in the assortment of Russian manufacturing enterprises in the light of the events of the last three years. The results of the study can be used to further study the relationship between business strategies and specific anti-crisis management measures of the assortment of economic entities specializing in production.
Convergence of CO2 emissions in the selected world countries
Authors: Grodzicki Tomasz , Jankiewicz Mateusz
Published: February 2023

Nowadays, the topic of CO2 emissions has been a subject of intensive debate. There is a significant policy push toward reducing emissions that cause air pollution and other environmental concerns. The aim of this paper is to analyze the CO2 emissions as well as economic growth along with renewable energy use and the level of urbanization in the selected World countries in the period of 1995-2018. In general, almost all of the Northern part of the World was characterized by a high level of CO2 emissions, while the majority of African territory was the least polluted. The empirical result shows that the growth rate of air pollution is much higher in countries that initially had a low level of CO2 emissions, so the convergence process occurred. Conditioning convergence with the renewable energy use and the urbanization level indicates that its speed is higher. Club convergence analysis has proved that well-developed regions in terms of GDP per capita are able to improve the ecological situation despite further economic growth.
Aynuna: A Case Study of the Changing Functions of a Hijazi Coastal Settlement from the Nabatean to the Early Islamic Period
Authors: Juchniewicz Karol
Published: February 2023

A recent study proved that Aynuna has been settled since at least the Hellenistic period and was the major settlement on the Arabian coast of the northern Red Sea in the Nabatean/Roman period, serving as the port of Petra. Scientific literature is mostly concerned with the identification of Aynuna with ancient Leuke Kome, leaving aside the later history of the site. In the late Roman/Byzantine period its significance as a trade centre slowly diminished, although it might have remained a tax collection point. In the early Islamic period, Aynuna served as a local agricultural centre and war port for the Arabian forces conquering the Eastern Desert. Later on, accessibility of fresh water made it a stop on the Egyptian Hajj Route, and antique Aynuna/Leuke Kome finally became Islamic ‘Aynūna. This paper aims to present a diachronic analysis of the changing functions of the site using published archaeological reports and Arabic written sources.
The Inscription of Tiberius Claudius Claudianus Hetereianus Engraved on a Marble Column Found in the ‘Saranda Kolones’ Castle at Nea Paphos, Cyprus
Authors: Kordas Anna Urszula
Published: February 2023

This paper offers the editio princeps of a Greek inscription engraved on a marble column discovered in the ‘Saranda Kolones’ Castle at Nea Paphos in Cyprus. The inscription, dated to the second or early third century AD, contains the names of the otherwise unknown Tiberius Claudius Claudianus Hetereianus, a member of the ordo equester, a founder of the column. This is the only known inscription mentioning the name Hetereianus. It remains an open question as to whether the man mentioned by the inscription was a Cypriot by birth or came to Cyprus, as well as whether he was the founder of this column only or a whole colonnade.
Global multiplicity for parametric anisotropic Neumann (p,q)-equations
Authors: Papageorgiou Nikolaos S. , Rădulescu Vicenţiu D. , Repovš Dušan D.
Published: February 2023

We consider a Neumann boundary value problem driven by the anisotropic
$(p,q)$-Laplacian plus a parametric potential term.
The reaction is ``superlinear". We prove a global (with respect to the parameter) multiplicity result for positive solutions.
Also, we show the existence of a minimal positive solution and finally, we produce
a nodal solution.
Multiple solutions for perturbed quasilinear elliptic problems
Authors: Bartolo Rossella , Candela Anna Maria , Salvatore Addolorata
Published: February 2023

We investigate the existence of multiple solutions
for the $(p,q)$-quasilinear elliptic problem
\[
\begin{cases}
-\Delta_p u -\Delta_q u\ =\ g(x, u) + \varepsilon\ h(x,u)
& \mbox{in } \Omega,\\
u=0 & \mbox{on } \partial\Omega,\\
\end{cases}
\]
where $1< p< q< +\infty$, $\Omega$ is an open bounded domain of
${\mathbb R}^N$, the nonlinearity $g(x,u)$ behaves at infinity as $|u|^{q-1}$,
$\varepsilon\in{\mathbb R}$ and $h\in C(\overline\Omega\times{\mathbb R},{\mathbb R})$.
In spite of the possible lack of a variational structure of this problem,
from suitable assumptions on $g(x,u)$ and
appropriate procedures and estimates,
the existence of multiple solutions can be proved for small perturbations.
Information Value Analysis for Real-Time Silo Fill-Level Monitoring
Authors: Greif Toni , Stein Nikolai , Flath Christoph M.
Published: February 2023

Supply chains in the construction industry are less efficient than in other industries (e.g., retail or automotive). The reason for the less optimized supply chains is often the lack of accurate, up-to-date information. For a leading supplier of building materials and construction systems, we perform a value of information analysis to guide future investments in costly sensors for silo fill-level monitoring. Silo inventory is vendor-managed as construction sites withdraw material from silos as they need it. Ensuring continuous availability of material requires proactive replenishment across products and customers. We establish the optimal purchase level of (partial) information for different hardware costs and service levels. Based on the current ensured service level regime, the minimum total costs are achieved with approximately 50% sensor-equipped silos for medium and high annual sensor costs. The findings on the appropriate use of information technology to improve decision making with partial information are generally relevant for suppliers looking to stand out with service guarantees and short delivery times.

History: This paper was refereed.
Blockchain Operations in the Presence of Security Concerns
Authors: He Jiahao , Zhang Guangyuan , Zhang Jiheng , Zhang Rachel Q.
Published: February 2023

Problem definition: A blockchain payment system, such as Bitcoin or Ethereum, validates electronic transactions and stores them in a chain of blocks without a central authority. Miners with computing power compete for the rights to create blocks according to a preset protocol, referred to as hashing or mining, and, in return, earn fees paid by users who submit transactions. Because of security concerns caused by decentralization, a transaction is confirmed after a number of additional blocks are subsequently extended to the block containing it. This confirmation latency introduces an intricate interplay between miners and users. This paper provides approximate system equilibria and studies optimal designs of a blockchain. Methodology/results: The hashing process is essentially a single-server queue with batch services based on a fee-based priority discipline, and confirmation latency adds complexity to the equilibrium behavior and optimal design. We analyze how miners’ participation decisions interact with users’ participation and fee decisions and identify optimal designs when the goal is to maximize the throughput or social welfare. We validate our model and conduct numerical studies using data from Bitcoin. Managerial implications: By incorporating security issues, we uncover the interdependence of the decisions between users and miners and the driver for nonzero entrance fees in practice. We show that miners and users may end up in either a vicious or virtuous cycle, depending on the initial system state. By allowing the entrance fee to be a design parameter, we are able to establish that it is optimal to simply run a blockchain system at its full capacity and a block size as small as possible.

Funding: This work was supported by the Hong Kong Research Grants Council [Grants 16200019, 16200617, 16200821, 16208120, and 16214121].

Supplemental Material: The e-companion is available at https://doi.org/10.1287/msom.2023.1197 .
el cultivo de las emociones a través de una educación emocional en la filosofía con niñas y niños
Authors: Albert Sonia París
Published: February 2023

Clarifying the concept of emotions is an essential task of 21st century societies. We cannot continue living if we ignore the importance they have in our everyday thinking and acting. Emotions are fundamental both to the private and the public sphere It is becoming increasingly important to learn to identify what we feel and what those around us feel, how we express these feelings and understand their consequences, in order to enable us to transform harmful emotions into others more favorable to the well-being of our personal relationships and our relationship with the environment. With this objective in mind, my text proposes a form of emotional education in the framework of peace education, initiated in early childhood, which acts to develop the emotional capacity required for the realization of a form of  critical, ethical and creative global citizenship. This work recovers the methodology of the school of philosophy with children, which gives a great sense of philosophical praxis to the text, by putting it in dialogue, also, with studies in philosophy for peace. Thus, it is essential to vindicate empathy and moral imagination from the time we are children. Through thinking based on care, fthe cultivation of an emotional education will stimulate to wonder about other emotional alternatives, escaping from our own limits and exploring the perspectives of others until we come to merge with their horizons.
creare i sensi della terra: il respiro naturale della comunità di indagine
Authors: Roversi Valentina , Cavallo Alessandra , Barenco mello contage Daniel
Published: February 2023

The earth is the archetypal image of the origin of humanity, but throughout the history of Western culture it has given way to other, more heavenly allegories. Enlightenment as a paradigm of knowledge consolidated itself in Western philosophical thought in a very convincing way as a production of meanings. Through this rereading of the first Greek metaphysics, thought gradually distanced itself from its materiality, from its humanity, from the possibility of admiring the concrete world, getting closer and closer to the need to create abstract objects, which, as ethical limits, political, aesthetic and epistemological, we end up meeting again in our lives. Visibility seems to be the basis of a Western mental habitus: recognition, officiality, legitimacy and certainty become visible signs with which we compare and validate our own experiences. The earth, as a less transparent element, with greater ability to hide, occult, encrypt represents, however, an image that is better suited to the discussion plan proposed in this text. The relationship with reality, in terms of visibility and invisibility, requires a new perception of the world: the underlying structure no longer assumes a transcendent level, but is understood as a plane of immanence, in which meaning is interior, produced by compositions; an amalgam of networks that intertwine in an imperceptible, invisible underground plane. What we propose here is not a vertical perspective, but a horizontal one like the ground. It is from this earthly thought that we want to reflect on what happens in philosophy and childhood; in philosophy with childhood and in the childhood of philosophy. In the present attempt of an ecophilosophy of education, the discussion plan requires a deviation from the guiding images with which we learn to do research. The intention of the following investigation is to look for another type of map: a kind of subterranean cartography, which pays attention not to what we can see, which has well-defined names and categories, but to what is hidden and inhabits a plane that is muddy, earthly, indistinguishable and absolutely alive. According to the Lipmanian model of Philosophy for Children, the subterranean and rhizomatic processes of the research community will be examined, comparing them to other collective movements that characterize the vegetable communities of plants that inhabit the natural world. Finally, three concepts considered relevant to escape the limits found in some contemporary pedagogical postures will be illustrated, suggesting other paths in the relationship between philosophy, childhood and education: reciprocity, passivity and invisibility.
IV OLIMPÍADA BRASILEIRA DE CARTOGRAFIA: CIÊNCIA E ARTE
Authors: Di Maio Angelica Carvalho , Santos Kellen Milene Gomes e , Carvalho Marcus Vinícius Alves de
Published: February 2023

A Olimpíada Brasileira de Cartografia é uma olimpíada científica de abrangência nacional, voltada para o ensino médio e 9º ano do ensino fundamental e este trabalho teve o objetivo de abordar o seu desenvolvimento, em especial de sua quarta edição, que teve como tema “Ciência e Arte”. A IV OBRAC propôs aos estudantes e professores desafios que envolveram cartografia e cinema e a representação multitemporal de fenômenos geoespaciais, além de abordar questões sobre a evolução da ciência dos mapas. Desde a sua primeira edição, observa-se que as experiências vividas pelas equipes ao longo da competição vão além do conteúdo cartográfico, contribuem para o desenvolvimento da capacidade de debater e tomar decisões em grupo, entorno de um propósito comum e em prol de ações cidadãs, que se estendem após o término do evento. Os resultados obtidos, a partir das atividades desenvolvidas na OBRAC, demonstraram o potencial de estudantes na resolução e participação em questões reais da sociedade e como respondem, de forma positiva, aos desafios que envolvem as geotecnologias e a construção de representações do espaço geográfico como forma de expressão ecomunicação.
A CARTOGRAFIA CONTANDO HISTÓRIA: UMA ANÁLISE DE BRUMADINHO/MG
Authors: Pereira Flávia Gama Nunes , Duarte Daniela Gonçalves , Carvalho Pedro Jardim de , Santos Ana Clara Brígido , Ferreira Letícia Lopes , Melo Isabela Campos
Published: February 2023

Este artigo apresenta a experiência da equipe SESI Barreiro na segunda etapa da IV Edição da Olimpíada Brasileira de Cartografia, no ano de 2021, organizada pela Universidade Federal Fluminense, com a temática Ciência e Arte. A proposta da segunda etapa foi o desenvolvimento de tarefas práticas, divididas em Fase 1 e Fase 2, com o objetivo de introduzir a Cartografia Social no meio educacional, no caso da equipe SESI com os alunos do 9º ano do Ensino Fundamental e 2ª série do Ensino Médio. Nesta perspectiva, a Fase 2 foi escolhida para ser relatada, pois se tratou do desenvolvimento de uma coleção de mapas que mostrasse as mudanças ocorridas em um local através de representações cartográficas. Optou-se pela pesquisa do município de Brumadinho, em Minas Gerais, devido sua grande importância na mineração brasileira e ser onde está localizado o Instituto Inhotim - maior museu a céu aberto do mundo e sede de um dos mais importantes acervos de arte contemporânea do Brasil – bem como a Mina Córrego do Feijão, destaque após o rompimento da barragem da empresa Vale em 2019. A partir desse enfoque, foi feito um trabalho intenso de investigação histórica a respeito do município, na busca por documentos, relatos e projeções cartográficas que pudessem contribuir para o projeto. Assim, foi realizada a coleção de mapas de Brumadinho através das décadas.
Inherited arrhythmias: considerations for nurses
Authors: Kirkby Claire , Renwick Catherine , Hargrave Joanne , Tobin Liam , Frampton Katie , Wilson Elizabeth , Nuthoo Soraya , Bueser Tootie
Published: February 2023

This article is the third instalment of the British Journal of Cardiac Nursing’s series on cardiac genetic concepts. Inherited arrhythmias are a group of conditions that affect the cardiac electrical system, typically resulting from changes in the way sodium, potassium or calcium ions are handled in the cell. Inherited arrhythmias can cause sudden cardiac death, especially in people who are undiagnosed and untreated. Most inherited arrhythmias are inherited in an autosomal dominant pattern. This article provides an overview of the aetiology, diagnosis, risk-management and treatment of patients with inherited arrhythmias at different ages and stages of life. The focus will be on inherited arrhythmias, specifically long QT, Brugada and catecholaminergic polymorphic ventricular tachycardia. There will be a brief mention of idiopathic ventricular fibrillation and sudden arrhythmic death syndrome.
Prevalência de inaptidão em doadores de sangue por insuficiência de hemoglobina/hematócrito em um Hemocentro do Extremo Norte do Brasil
Authors: Ribeiro Roque Daniela , Furtado de Amorim Nahmias Nerlene , Alves da Fonseca Ricardo , Christian Almeida de Carvalho Fabíola
Published: February 2023

A hemoglobina e hematócrito baixos são os maiores fatores de inaptidão nos candidatos a doação de sangue, principalmente em candidatas do sexo feminino, devido à menstruação e gestação. A investigação socioepidemiológica do doador visa garantir segurança para o doador e o receptor e ocorre através do processo de triagem nos bancos de sangue. No Brasil, as legislações que regem a hemoterapia são as RDC 034, de 2014, e a Portaria de Consolidação nº 05, de 2017. Objetivo: Traçar o perfil epidemiológico dos candidatos à doação de sangue inaptos por insuficiência de hemoglobina/hematócrito, em relação a sexo, idade, cor autodeclarada e escolaridade; analisar o impacto da inaptidão desses doadores, no ano de 2020, e inferir o percentual das inaptidões pesquisadas no quadro de inaptidão geral do Hemocentro de Roraima (Hemoraima). Métodos: Trata-se de estudo transversal, retrospectivo, com dados secundários disponibilizados pelo Hemoraima, de 11.635 candidatos à doação de sangue no Hemoraima, no período de janeiro de 2020 a dezembro de 2020. Resultados: Desses candidatos, 1.790 foram considerados inaptos (15,38%), sendo que 478 destes inaptos por insuficiência de hemoglobina/hematócrito (Hb/Ht) correspondem a 26,70% dos candidatos inaptos. Conclusão: Destaca-se que o perfil mais encontrado foi de mulheres entre 20 e 29 anos, caucasianas brasileiras de nível médio completo.
Repercussões e estratégias de cuidado em saúde mental: cuidando do trabalhador de saúde no enfrentamento da COVID-19
Authors: Lima Israel Coutinho Sampaio , Belarmino Adriano da Costa , Rodrigues Maria Eunice Nogueira Galeno , Ferreira Junior Antonio Rodrigues , Cavalcante Ana Suelen Pedroza , Sampaio José Jackson Coelho
Published: February 2023

A saúde mental dos trabalhadores da saúde precisa ser rediscutida como uma questão de saúde ocupacional a ser promovida e preservada, sobretudo em situações de crise, como a vivida atualmente na pandemia da COVID-19. O estudo buscou refletir sobre as repercussões e estratégias diante do sofrimento psíquico vivido por trabalhadores de saúde no enfrentamento da COVID-19. Para tanto, construiu-se uma reflexão sobre a influência da política nacional e da pandemia atual na saúde mental dos trabalhadores. Sugere-se que as estratégias para a promoção e a preservação da saúde mental dos trabalhadores que enfrentam a COVID-19 devem considerar três grandes nós críticos: apoio governamental, com garantia das leis de saúde e segurança ocupacional, bem como planejamento baseado em evidências; apoio organizacional, com foco na educação permanente, garantia de equipamentos de proteção individual e suporte psicossocial; apoio social, que engloba os suportes familiares, comunitários e trabalhadores. Assim, a saúde mental dos trabalhadores da saúde é influenciada pelas atividades laborais no enfrentamento da COVID-19, especialmente em um ambiente de precarização do trabalho, constituindo-se desafio a ser superado no sistema de saúde a implantação de estratégias de apoio.
Qualidade de vida de mães de crianças com deficiências físicas e mentais
Authors: De Campos Fruhling Maryana Thais , Bravo Daiane Suele , Pereira Gomes Maria Fernanda , Souza Santos Mariana , Ramos Lopes Valverde Vanessa , Fracolli Lislaine Aparecida
Published: February 2023

Objetivo: Avaliar a qualidade de vida de mães de filhos com deficiência física e/ou mental. Método: Estudo transversal, avaliativo, de abordagem quantitativa, desenvolvido com mães dos projetos destinados ao acompanhamento de crianças com algum grau de deficiência física e/ou mental, em um município do interior de São Paulo, utilizando como instrumento de avaliação o World Health Organization Quality of Life (WHOQOL-BREF), versão em português. Resultados: Os domínios geral, físico, psicológico, relações sociais e ambientais foram classificadas como regulares. No domínio psicológico, a imagem corporal e aparência precisam de aprimoramento. No domínio meio ambiente, os recursos financeiros, acesso a informações e habilidades, assim como o ambiente físico também receberam pontuações que apontam a necessidade de melhorar. Conclusão: Pesquisas adicionais são necessárias para enfatizar as necessidades das mães cuidadoras, a satisfação com o tratamento oferecido e as dificuldades de acesso a serviços especializados e redes de apoio.
Pancreatoblastoma in previously pancreatic pseudocysts in a 14-year-old female: a case report
Authors: Bellynda Monica , Marsih  , Adinugroho Yohanes , Suwardi  , Riza Muhammad , Muhammad Faizal
Published: February 2023

Pancreatoblastoma is a rare tumor characterized by uncontrolled growth of pancreatic epithelial cells with a mix of squamous nests and acinar differentiation. Diagnostic modalities include abnormal liver enzyme, pancreatic enzyme, and imaging findings. Treatment options include surgical resection, sometimes combined with chemotherapy, depending on the tumor’s size and grade. We reported a pancreatoblastoma in a 14-year-old female with prior pancreatic pseudocysts. The transformation from pseudocysts to pancreatoblastoma is believed to be caused by the heterozygosity molecular loss on the 11p chromosome and several genetic mutations. Magnetic resonance cholangiopancreatography showed a well-defined, heterogeneous mass in the pancreatic head, with 70% of the mass composed of cysts. A partial pancreatectomy was performed because a complete pancreatectomy may harm the adjacent structures. However, a complete resection combined with chemoradiation may be the best option for long-term survival and complete remission. In this case, she was disease-free until 30 months after the chemotherapy protocol.
Familiarity matters: corporate philanthropy and employee workplace giving and volunteering
Authors: Daniel Heist H. , Shaker Genevieve , Christensen Robert K.
Published: February 2023

Employees create and enact corporate philanthropy (CP) programmes, which are a central strategy of corporate social responsibility (CSR) strategies. Employers rely on employees to donate and volunteer through the workplace. From a survey of more than 500 employees at a large corporation based in the United States, we determined that employees’ likelihood of participating in CP is affected by their length of job tenure, managerial responsibilities and work location (on- or off-site). Using structural equation modelling, we found that employee familiarity with the company’s CP programmes mediates the relationship between giving and volunteering with management positions and working on-site. Employee perception also matters. Employees who think highly of CP programmes’ community impact and workplace environment outcomes (CP ‘walk’) are more likely to give and volunteer. Conversely, perceptions of the company ‘standing out’ (CP ‘talk’) in its industry are negatively related to volunteering with the company. Findings contribute to the development of meso-level dynamics in workplace giving.
Legal institutions, perceptions and entrepreneurship: an empirical investigation
Authors: Dove John A. , Dove Laura R.
Published: February 2023

This study assesses how perceptions about the quality of legal institutions affect entrepreneurial activity across US states. We employ survey data from the US Chamber of Commerce’s Institute for Legal Reform regarding both the overall perceived institutional quality within a state and a multitude of subcategories. With a panel data set covering 2002–08, we find that along with overall legal quality, entrepreneurial activity across states is positively correlated with better perceptions about punitive damages, summary judgment, rules of discovery and admission of scientific and technical evidence at trial. Interestingly, interacting these variables with economic freedom typically generates non-results, though this is not the case when considering only opportunity entrepreneurship. Implications are discussed.
Low-Loss, O- and C-Band, 4-core MCF Fanouts for Datacom SDM Applications
Authors: Kopp Victor , Park Jongchul , Singer Jonathan , Neugroschl Dan , Takenaga Katsuhiro , Nasir Usman
Published: February 2023

We demonstrate a broadband, low-loss pair of fanouts fusion spliced to a 200-meter-long, 4-core, datacom MCF covering both the O- and C-bands with loss smaller than 0.6 and 0.4 dB, respectively. Near field mode profiling allows for fine adjustment of the mode field.
A systematic review to explore how exercise-based physiotherapy via telemedicine can promote health related benefits for people with cystic fibrosis
Authors: Ben Bowhay  , Latour Jos M. , Tomlinson Owen W.
Published: February 2023

To conduct a systematic review to evaluate the effects of physiotherapy exercises delivered via telemedicine on lung function and quality-of-life in people with Cystic Fibrosis (CF). The databases AMED, CINAHL and MEDLINE were searched from December 2001 until December 2021. Reference lists of included studies were hand-searched. The PRISMA 2020 statement was used to report the review. Studies of any design reported in the English language, included participants with CF, and within outpatient settings were included. Meta-analysis was not deemed appropriate due to the diversity of interventions and heterogeneity of the included studies. Following screening, eight studies with 180 total participants met the inclusion criteria. Sample sizes ranged from 9 to 41 participants. Research designs included five single cohort intervention studies, two randomised control trials and one feasibility study. Telemedicine-based interventions included Tai-Chi, aerobic, and resistance exercise delivered over a study period of six to twelve weeks. All included studies which measured percentage predicted forced expiratory volume in one second found no significant difference. Five studies measuring the Cystic Fibrosis Questionnaire–Revised (CFQ-R) respiratory domain found improvements, however, did not meet statistical significance. For the CFQ-R physical domain, measured by five studies, two studies found an improvement, although not statistically significant. No adverse events were reported across all studies. The included studies indicate that telemedicine-based exercise over 6–12 weeks does not significantly change lung function or quality-of-life in people with CF. Whilst the role of telemedicine in the care of pwCF is acceptable and promising; further research with standardised outcome measures, larger sample sizes and longer follow-up are required before clinical practice recommendations can be developed.
Colonization of intervertebral discs by Cutibacterium acnes in patients with low back pain: Protocol for an analytical study with microbiological, phenotypic, genotypic, and multiomic techniques
Authors: Magno da Rocha Vinícius , Lima Carla Ormundo Gonçalves Ximenes , Ferreira Eliane de Oliveira , de Farias Gabriel Corrêa , Nogueira Fábio César Sousa , Martha Antunes Luis Caetano , Cassiano Keila Mara , Fiorelli Rossano Kepler Alvim
Published: February 2023

Lumbar disc degeneration (LDD) and low back pain (LBP) are two conditions that are closely related. Several studies have shownCutibacterium acnescolonization of degenerated discs, but whether and how these finding correlates with LBP is unknown. A prospective study was planned to identify molecules present in lumbar intervertebral discs (LLIVD) colonized byC.acnesin patients with LDD and LBP and correlate them with their clinical, radiological, and demographic profiles. The clinical manifestations, risk factors, and demographic characteristics of participants undergoing surgical microdiscectomy will be tracked. Samples will be isolated and pathogens found in LLIVD will be characterized phenotypically and genotypically. Whole genome sequencing (WGS) of isolated species will be used to phylotype and detect genes associated with virulence, resistance, and oxidative stress. Multiomic analyses of LLIVD colonized and non-colonized will be carried out to explain not only the pathogen’s role in LDD, but also its involvement in the pathophysiology of LBP. This study was approved by the Institutional Review Board (CAAE 50077521.0.0000.5258). All patients who agree to participate in the study will sign an informed consent form. Regardless of the study’s findings, the results will be published in a peer-reviewed medical journal. Trials registration number NCT05090553; pre-results.
Assessing the impact of community-based interventions on hypertension and diabetes management in three Minnesota communities: Findings from the prospective evaluation of US HealthRise programs
Authors: Fullman Nancy , Cowling Krycia , Flor Luisa S. , Wilson Shelley , Bhatt Paurvi , Bryant Miranda F. , Camarda Joseph N. , Colombara Danny V. , Daly Jessica , Gabert Rose K. , Harris Katie Panhorst , Johanns Casey K. , Mandile Charlie , Marshall Susan , McNellan Claire R. , Mulakaluri Vasudha , Phillips Bryan K. , Reitsma Marissa B. , Sadighi Naomi , Tamene Tsega , Thomson Blake , Wollum Alexandra , Gakidou Emmanuela
Published: February 2023

Background

Community-based health interventions are increasingly viewed as models of care that can bridge healthcare gaps experienced by underserved communities in the United States (US). With this study, we sought to assess the impact of such interventions, as implemented through the US HealthRise program, on hypertension and diabetes among underserved communities in Hennepin, Ramsey, and Rice Counties, Minnesota.

Methods and findings

HealthRise patient data from June 2016 to October 2018 were assessed relative to comparison patients in a difference-in-difference analysis, quantifying program impact on reducing systolic blood pressure (SBP) and hemoglobin A1c, as well as meeting clinical targets (< 140 mmHg for hypertension, < 8% Al1c for diabetes), beyond routine care. For hypertension, HealthRise participation was associated with SBP reductions in Rice (6.9 mmHg [95% confidence interval: 0.9–12.9]) and higher clinical target achievement in Hennepin (27.3 percentage-points [9.8–44.9]) and Rice (17.1 percentage-points [0.9 to 33.3]). For diabetes, HealthRise was associated with A1c decreases in Ramsey (1.3 [0.4–2.2]). Qualitative data showed the value of home visits alongside clinic-based services; however, challenges remained, including community health worker retention and program sustainability.

Conclusions

HealthRise participation had positive effects on improving hypertension and diabetes outcomes at some sites. While community-based health programs can help bridge healthcare gaps, they alone cannot fully address structural inequalities experienced by many underserved communities.
Empirical parameterisation and dynamical analysis of the allometric Rosenzweig-MacArthur equations
Authors: McKerral Jody C. , Kleshnina Maria , Ejov Vladimir , Bartle Louise , Mitchell James G. , Filar Jerzy A.
Published: February 2023

Allometric settings of population dynamics models are appealing due to their parsimonious nature and broad utility when studying system level effects. Here, we parameterise the size-scaled Rosenzweig-MacArthur differential equations to eliminate prey-mass dependency, facilitating an in depth analytic study of the equations which incorporates scaling parameters’ contributions to coexistence. We define the functional response term to match empirical findings, and examine situations where metabolic theory derivations and observation diverge. The dynamical properties of the Rosenzweig-MacArthur system, encompassing the distribution of size-abundance equilibria, the scaling of period and amplitude of population cycling, and relationships between predator and prey abundances, are consistent with empirical observation. Our parameterisation is an accurate minimal model across 15+ orders of mass magnitude.
Study on the linkage between macro policy and market effectiveness in China’s stock market: Based on run test of China’s stock market index
Authors: Liu Manqing , Ding Shiting , Pan Qintian , Zhang Yanming , Zhang Jingru , Yang Qiong , Fang Tongtong
Published: February 2023

The macro policy of the stock market is an important market information. The implementation goal of the macro policy of the stock market is mainly to improve the effectiveness of the stock market. However, whether this effectiveness has achieved the goal is worth verifying through empirical data. The exertion of this information utility is closely related to the effectiveness of the stock market. Use the run test method in statistics to collect and sort out the daily data of stock price index in recent 30 years, the linkage between 75 macro policy events and 35 trading days of market efficiencies before and after the macro event are tested since 1992 to 2022. The results show that 50.66% of the macro policies are positively linked to the effectiveness of the stock market, while 49.34% of the macro policies have reduced the effectiveness of the market operation. This shows that the effectiveness of China’s stock market is not high, and the nonlinear characteristics are obvious, so the policy formulation of the stock market needs further improvement.