bluuebunny/crossref_metadata_2025 huggingface dataset:
ŞAİR İSMÂİL‘İN MANZUM BİR HİKÂYESİ VE ÖMER SEYFEDDİN’İN ÜÇ NASİHAT‘İ
Authors: CEYHAN Adem , KOYUNCU Fatih
Published: July 2023

Anlatma esasına bağlı metinlerden olan hikâyelere kadim eserler içerisinde rastlanmaktadır. Bir durumun olay örgüsü içinde nakledildiği hikâye, Batı ve Doğu kültüründe benzer gelişim seyri göstermiştir. Bilhassa kutsal metinlerde hikâyelerin yer alması, bu türe olan ilgiyi arttırmıştır. Klasik Türk Edebiyatı devrinde kaleme alınan eserler arasında hikâye türünden metinler oldukça fazladır. Bu eserler, önce halk hikâyeleri çerçevesinde yazılmış, edebiyatın zamanla klasikleşmesiyle başta dil ve üslup olmak üzere çeşitli yönlerden farklılık arz etmiştir. Bu değişim esnasında önde gelen yazar veya şairlerin sanat kudretini gösterme amaçlarının da tesiri vardır. Manzum, mensur ve manzum-mensur olarak örneklerine rastlanan bu eserlerden biri de Şair İsmâil’e aittir. Müellifin hayatı hakkında her hangi bir bilgi bulunmamaktadır. Elyazması bir mecmuada üç kitapçığına rastlanan şairin bu mazi yadigârındaki son eseri “Hikâyet-i Tâcir…” başlıklı mesnevisidir. Olağanüstü hadiselerin de yer aldığı eserde zengin bir tacirin oğlu ve onun iyi sonu anlatılmıştır. Mesnevide vakanın kahramanına verilen üç nasihat ve bu öğütleri tutmanın faydası ortaya konmak istenmiştir. Bu yönüyle metin bazı ahlaki telkinlerde bulunmak üzere tasarlanmış öğretici bir hikâyedir. Yapılan araştırma neticesinde bu hikâyenin Ömer Seyfeddin’in “Üç Nasihat” adlı hikâyesiyle benzerlikler gösterdiği anlaşılmıştır. Tarihî metinlerle günümüzde veya yakın zamanda –bilhassa konusunu Arap, Fars ve Türk edebiyatı tarihinden almış- hikâyelerin, metinlerarası münasebetler yönünden incelenmesi gerekli görünmektedir. Bu çalışmada, Şair İsmâil hakkında bilgi verildikten sonra söz konusu iki eser mukayese edilmiş ve her iki hikâyenin metni sunulmuştur.
FAMILY SUBJECTIVE WELL-BEING AT THE EARLY OF COVID-19 PANDEMIC IN INDONESIA
Authors: Oktriyanto Oktriyanto , Nasution Sri Lilestina , Pujihasvuty Resti , Puspitasari Mardiana Dwi , Amrullah Hilma , Murniati Chairunnisa , Puspitawati Herien , Herawati Tin
Published: July 2023

Families in Indonesia experienced changes and economic pressures in the early days of the COVID-19 pandemic. This research is very important to know the full picture of family resilience in Indonesia, especially in the economic aspect. This study analyzes economic changes, coping strategies, and their effects on subjective family welfare at the pandemic's start. Data were collected through a Family Condition Survey, carried out specifically through online media, for 14 days in 34 provinces. The unit of analysis in this study is the family, that is married couples who have or do not have children, with a total sample of 20,680 respondents. This study conducted univariate, bivariate, and multivariate analyses using Cross Tabulation, Chi-Square Test and Binary Logistic Regression with Odds Ratio. The results of the study show that there are worsening economic changes, such as working conditions, finances and food adequacy. In this case, environmental factors are the family's socioeconomic and financial conditions (education, income, employment), which are still the main factors and significantly influence the subjective well-being of the family. However, the subjective welfare of families in Indonesia is still quite good; most families are still happy, remain grateful, and communicate well. Coping strategies in managing family finances, such as saving and using savings, are the most widely used. However, these efforts are constrained by low family income and increased additional needs during the pandemic. There is a need for further research that can fully describe post-pandemic family economic coping strategies in the last 12 months.
MEASURING THE ROLE OF FAMILY FUNCTION IN PROMOTING ADOLESCENT REPRODUCTIVE HEALTH IN EAST JAVA
Authors: Khurun'in Irza , Hariastuti Iswari , Siswidiyanto Siswidiyanto , Sujawoto Sujarwoto
Published: July 2023

A family function has a critical role in adolescent development especially in socializing healthy sexual behavior. However, studies around family function and reproduction health of adolescents are still limited. This research analyzes the link between family function on knowledge, attitude, and healthy sexual behavior among adolescents in East Java Province. Generalized Structural Equation Modelling (GSEM) was applied to the 2019 Performance and Accountability Survey (SKAP) 2019 East Java Province which consists of 32,194 families and 5,300 adolescents aged 10-24 years old. The results show that family functions are not well established, adolescents' knowledge of reproductive health is still low, and most adolescents have a negative attitude toward various population issues. The ability of families to socialize the five family function values is related to adolescent knowledge of reproductive health, positive attitudes toward population issues, and healthy reproductive behavior. This study suggests the importance of strengthening family functions to establish healthy reproductive behavior among adolescents in East Java.
QUALITY OF LIFE DURING PREGNANCY: A COMPARATIVE STUDY BETWEEN URBAN AND RURAL AREAS IN INDONESIA
Authors: Puspitasari Nunik
Published: July 2023

Assessing quality of life during pregnancy is vital to find timely preventive measures against pregnancy complications. The quality of life during pregnancy determines pregnant women’s health. This study aims to identify the differences in the quality of life during pregnancy who participated in antenatal care (ANC) visits in primary healthcare centers in rural and urban areas. This study used a cross-sectional design and collected data through  survey. The research population was 800 pregnant women who participated in ANC in three primary healthcare centers in urban areas and three others in rural areas. The quality of life during pregnancy questionnaire was used for data collection. The analysis was done using the Chi-square test and ordinal regression. Results showed no difference in the quality of life during pregnancy between women in urban areas and those in rural areas. Some factors that affected the quality of life during pregnancy included education, fetal age, number of pregnancies, number of live children, and pregnancy plans in women living in urban areas. Meanwhile, in women living in rural areas, the quality of life during pregnancy was affected by education level, occupation, fetal age, number of pregnancies, number of live children, and pregnancy plans. There are influences of age, education level, occupation, gestational age, number of pregnancies, number of living children, and pregnancy plans on the quality of life of pregnant women in rural areas.
Obstacles and Opportunities Of Implementing Asta Ethics Librarians In Library Information Services In Indonesia
Authors: Abiel Yehuda , Masruri Anis
Published: July 2023

ABSTRACT

Ethics itself is very closely related to human existence as individuals in society. In society, harmonious coexistence of individuals cannot be separated from ethics that are able to harmonize existing differences. Ethics is also regulated in every religion. All religions teach three main things in their holy books, namely the nature of God, ethics/morality, and rituals/worship. There is no religion that does not teach ethics. The higher the faith, the better the morals. The Librarian Code of Ethics is a starting point for librarians in carrying out their duties, in which there are guidelines for behavior that can be used to avoid unprofessional behavior. This research was conducted using descriptive qualitative research methods supported by literature studies. As many as 6 of the 7 librarians interviewed admitted that they had never heard of Asta Librarian Ethics, while 1 librarian stated that they had heard of Asta Ethics for Librarians, and this shows that this code of ethics is not very popular among librarians. IPI itself has a crucial role in the development of librarianship in Indonesia and the application of an even code of ethics to librarians in Indonesia which is oriented towards excellent service to and satisfaction of users and society in general.

Keywords: Ethics, librarian, organization, indonesia.

 

OBSTACLES AND OPPORTUNITIES OF IMPLEMENTING ASTA ETHICS LIBRARIANS IN LIBRARY INFORMATION SERVICES IN INDONESIA

ABSTRAK
Etika sendiri sangat erat kaitannya dengan eksistensi manusia sebagai individu yang hidup di tengah-tengah masyarakat. Keharmonisan interaksi antar-individu dalam masyarakat tidak lepas dari etika yang sanggup menyelaraskan perbedaan yang terjadi. Etika pun juga diatur dalam setiap agama. Menurut Agoes (2011) semua agama mengajarkan melalui kitab sucinya tiga hal pokok yaitu hakikat Tuhan, etika/tata susila dan ritual/tata cara beribadah. Tidak ada agama yang tidak mengajarkan etika. Semakin tinggi keimanan seseorang seharusnya menjadi semakin baik etika yang dimilikinya.  Kode Etik Pustakawan merupakan pijakan awal bagi para pustakawan dalam melaksanakan tugasnya di tempat ia bekerja, yang di dalamnya memberikan pedoman tingkah laku yang dapat menghindarkan diri dari tindakan yang tidak professional. Penelitian ini dilakukan menggunakan metode penelitian kualitatif deskriptif yang didukung dengan studi literatur. Penulis mencoba mewawancari 7 pustakawan dari 3 perpustakaan perguruan tinggi di Indonesia dan 6 dari 7 pustakawan tersebut mengaku belum pernah sekalipun mendengar tentang Asta Etika Pustakawan. IPI sendiri memiliki peranan krusial dalam perkembangan kepustakawanan di Indonesia dan penerapan kode etik yang merata kepada pustakawan di Indonesia yang berorientasi kepada layanan prima kepada dan kepuasan pemustaka serta masyaarakat pada umumnya.

Keywords: Etika, pustakawan, organisasi, indonesia
Analysis of Communication Effectiveness in the Digital Era as a Communication Media for iGeneration (Gen Z) during the Recovery Period of the COVID-19 Pandemic
Authors: Purnawati Juli , Kurniawati Dewi
Published: July 2023

ABSTRACT
All sectors are feeling the impact of the Corona virus outbreak, such as education, the economy, tourism, and others. This has also shifted the direct interpersonal communication system to the digital (online) media communication system. With the COVID-19 virus, all universities in North Sumatra, both public and private, received an appeal from the government to implement PSBB (Large-Scale Social Restrictions) and carry out social distancing, where all employees, lecturers, and students of the University of North Sumatra are required to carry out their activities and daily operations at WFH (Work From Home) homes. However, during this recovery period, campus activities began to be carried out offline and also online, so the purpose of this study was to identify and analyze the effectiveness, constraints, and digital communication solutions during the pandemic (COVID-19) and recovery during the COVID-19 pandemic. , in the Master of Communication Science, University of North Sumatra. This research was conducted using a qualitative approach and a descriptive method. The research results show the effectiveness of digital communication during the COVID-19 pandemic and COVID-19 recovery.
 Keywords: efektivitas, komunikasi digital, Pandemi COVID-19 dan Pemulihan COVID-19

Analisis Efektivitas Komunikasi di Era Digital Sebagai Media Komunikasi Pada iGeneration (Gen Z) di Masa Pemulihan Pandemi COVID-19 (Studi Deskriptif MIKOM USU 2022)
ABSTRAK
Semua sektor merasakan dampak dari wabah virus Corona, seperti pendidikan, ekonomi, pariwisata, dan lain-lain. Hal ini juga telah menggeser sistem komunikasi interpersonal langsung ke sistem komunikasi media digital (online)(Ardiyanti, 2020). Dengan adanya virus COVID-19, seluruh perguruan tinggi di SUMUT baik negeri maupun swasta mendapat himbauan dari pemerintah untuk menerapkan PSBB (Pembatasan Sosial Berskala Besar) dan melakukan social distancing, dimana seluruh karyawan, dosen, dan mahasiswa Universitas Sumatera Utara diwajibkan untuk melaksanakan kegiatan pekerjaan dan operasional sehari-hari mereka di rumah WFH (Work From Home). Namun pada masa recovery ini, kegiatan kampus mulai dilakukan secara offline dan juga online, sehingga tujuan dari penelitian ini adalah untuk mengidentifikasi dan menganalisis efektifitas, kendala, dan solusi komunikasi digital pada masa pandemi COVID-19 dan pemulihan pada masa pandemi COVID-19, di Magister Ilmu Komunikasi, Universitas Sumatera Utara. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif dan metode deskriptif. Hasil penelitian menunjukkan efektivitas komunikasi digital selama pandemi COVID-19 dan pemulihan COVID-19.
Kata Kunci : efektivitas, komunikasi digital, Pandemi COVID-19 dan Pemulihan COVID-19
Heart failure with preserved left ventricular ejection fraction in non-obstructive coronary artery disease: clinical utility of heart rate variability
Authors: Grakova E. V. , Kopeva K. V. , Gusakova A. M. , Smorgon A. V. , Akhmedov Sh. D. , Kalyuzhin V. V. , Teplyakov A. T.
Published: July 2023

Aim. To evaluate the role of heart rate variability in the pathogenesis of chronic heart failure with preserved ejection fraction (HFpEF) in patients with non-obstructive coronary artery disease (CAD).

Materials and methods. The cross-sectional study included 65 patients (55.4% were males) with non-obstructive CAD. Non-obstructive CAD (stenosis < 50%) was confirmed by coronary computed tomography angiography. Heart rate variability (HRV) was evaluated by 24-hour Holter monitoring; parameters of time series and spectral analysis were analyzed.

Results. Depending on the presence of HFpEF, the patients were divided into 2 groups: group 1 (n = 48) included patients with HFpEF, and group 2 (n = 17) encompassed patients without it. In patients with HFpEF, a statistically significant decrease in the total HRV and parasympathetic effects on the heart rate, mainly at night, as well as increased activity of cerebral ergotropic systems were revealed. In group 1, the values of the time series analysis of HRV and QT dispersion based on the study of RR interval duration (SDANN and SDNNidx) had a significant direct relationship with the level of myocardial stress in diastole, the value of vascular resistance, and the E / e’ ratio. The cut-off values of SDNNidx and pNN50 were identified, that may be used as markers for early diagnosis of HFpEF.

Conclusion. In patients with non-obstructive CAD and HFpEF, it is advisable to perform 24-hour Holter monitoring and assess HRV parameters by the time series analysis, which, compared with the spectral analysis, has a closer relationship with the characteristics of left ventricular diastolic function and afterload.
Viability of mononuclear cells in leukocyte concentrates at the stages of their preparation, freezing, and thawing
Authors: Isaeva N. V. , Minaeva N. V. , Utemov S. V. , Sherstnev F. S. , Zorina N. A. , Zmeeva Yu. S. , Butolina M. A.
Published: July 2023

Aim. To evaluate the viability of mononuclear cells (MNCs) in leukocyte concentrates (LCs) at the stages of their preparation, freezing, and thawing.

Materials and methods. The study material included 44 LCs from donors of allogeneic hematopoietic stem cells (HSCs) and 189 autologous LCs from patients with oncohematological disorders. LCs were obtained from donors and patients by leukocytapheresis after mobilization of HSCs. LCs from patients were frozen with dimethyl sulfoxide (DMSO) used as a cryoprotectant at a final concentration of 5% and stored in liquid nitrogen. LCs were thawed before transplantation. A total of 161 LCs were immediately transfused to the recipient after thawing, and 28 LCs were washed from DMSO before transfusion. Flow cytofluorometry was used to determine the percentage of MNC populations that excluded 7-aminoactinomycin D (7-AAD).

Results. The viability of peripheral blood MNCs in donors and patients was close to 100%. It was found that leukocytapheresis and cryopreservation with DMSO did not affect the viability of MNCs. The freezing of LCs with DMSO, storage in liquid nitrogen, and thawing resulted in a significant decrease in the content of viable MNCs (p = 0.0025), while no effect of LC storage duration on the viability of MNCs was revealed. Following DMSO removal from LCs, significantly more HSCs remained in a viable state than without washing (94.4 [94.5; 95.2] % vs. 86.7 [67.6; 92.9] %, (p = 0.0051); for other MNC populations, except monocytes, the differences in the viability index were also statistically significant.

Conclusion. The viability of MNCs in LCs is recommended to be used as an independent characteristic of the transplant quality. In obtaining LCs and mixing them with the cryoprotectant DMSO, the viability of MNCs does not decrease, while in thawed LCs, it decreases significantly. Thawing of LCs with removal of DMSO allows to achieve the best viability of HSCs and most MNC populations.
Renal venous Doppler ultrasound – a new parameter for predicting outcomes in patients with decompensated heart failure
Authors: Kobalava Zh. D. , Safarova A. F. , Aslanova R. Sh. , Vatsik-Gorodetskaya M. V.
Published: July 2023

Aim. To assess the frequency, dynamics, and prognostic value of renal venous congestion using Doppler ultrasound in patients with decompensated heart failure (DHF).

Materials and methods. A prospective, single-center study included 124 patients with DHF (mean age 70 ± 12 years, 51.6% were males), left ventricular ejection fraction (LVEF) 44 [34; 55] %, N-terminal pro B-type natriuretic peptide (NT-proBNP) 1,609 [591; 2,700] pg / ml. All patients underwent a standard physical examination and laboratory and instrumental tests, including the assessment of the NT-proBNP level. Renal venous blood flow was assessed using pulsed-wave Doppler ultrasound. The presence of continuous renal blood flow was considered as the absence of venous congestion, while intermittent blood flow (two-phase and single-phase flow) indicated venous congestion. Rehospitalization for DHF and reaching a composite endpoint (rehospitalization for DHF and cardiovascular mortality) within 12 months after discharge were selected as endpoints.

Results. At admission, continuous renal venous blood flow was observed in 34 (27.4%) patients, intermittent renal venous blood flow was found in 90 (72.6%) patients: two-phase flow in 62 (50%) and single-phase flow in 28 (22.6%) patients with DHF. At discharge, 66 (53.2%) patients had intermittent renal venous blood flow: two-phase flow in 50 (40.3%) and single-phase flow in 16 (12.9%) patients. Correlations of renal venous congestion with the levels of NT-proBNP, serum iron, uric acid, creatinine, LVEF, systolic pressure in the pulmonary artery (SPPA), and the development of acute kidney injury (AKI) were revealed. Persistent renal venous congestion at discharge was significantly associated with a higher probability of rehospitalization for DHF (hazard ratio (HR) 1.93 95% confidence interval (CI) (1.017–3.67); p = 0.044) and a composite endpoint (HR 2.66, 95% CI (1.43–4.96); p = 0.002).

Conclusion. In patients with DHF, it is necessary to evaluate renal venous blood flow using pulsed-wave Doppler ultrasound to stratify patients with development of cardiovascular complications within 12 months.
Features of bacterial DNA taxonomy in blood of patients with various metabolic phenotypes of obesity
Authors: Kolesnikova I. M. , Karbyshev M. S. , Gaponov A. M. , Khusnutdinova D. R. , Grigoryeva T. V. , Kamaldinova D. R. , Borisenko O. V. , Makarov V. V. , Yudin S. M. , Roumiantsev S. A. , Shestopalov A. V.
Published: July 2023

Aim. To study the blood microbiome taxonomy in patients with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO).

Materials and methods. The study included healthy donors without obesity (n = 116) and obese patients who were divided into subgroups with MHO (n = 36) and MUHO (n = 53). Bacterial DNA isolated from blood samples was subject to metagenomic sequencing of the v3–v4 variable region in the 16S rRNA gene. We compared the frequency of isolating certain taxa from the samples and the proportion of these taxa in the total pool of bacterial DNA in the blood.

Results. MUHO patients showed an increase in Lachnospiraceae, Ruminococcaceae, and Prevotellaceae, which are the main taxa in gut microbiota. This may indicate greater intestinal permeability in such patients. Obese patients, regardless of the metabolic phenotype of obesity, more often had Rhodobacteraceae, Streptomycetaceae, Leuconostocaceae, and Burkholderiaceae DNA in their blood. Nocardioidaceae, Flavobacteriaceae, Hyphomicrobiaceae, and Gaiellaceae DNA were more frequently present in the blood microbiome of patients with MHO, whereas MUHO patients more often had S24-7, Nocardiaceae, and Helicobacteraceae DNA in their blood. Many members of these families inhabit soil and water, which may indicate increased skin barrier permeability in obese patients. Additionally, a higher number of Helicobacteraceae-positive blood samples in the MUHO patient group may indicate increased translocation from the stomach.

Conclusion. Obesity is accompanied by changes in the taxonomic composition of the blood microbiome. Moreover, the nature of the changes depends on the metabolic phenotype of obesity and the permeability of external barriers.
mRNA level of antioxidant genes and activity of NADPH-generating enzymes in rotenone-induced parkinsonism in rats
Authors: Kryl’skii E. D. , Razuvaev G. A. , Popova T. N. , Nikhaev L. E. , Akinina A. I.
Published: July 2023

Aim. To analyze the mRNA level of genes encoding antioxidant enzymes and the transcription factors Nrf2 and Foxo1 regulating their expression and the activity of glucose-6-phosphate dehydrogenase (G6PDH) and NADPdependent isocitrate dehydrogenase (NADP-IDH) and assess the correlation between these parameters, oxidative status, and motor coordination parameters in rats with rotenone-induced parkinsonism.

Materials and methods. The study was performed on male Wistar rats aged 4–6 months and weighing 200–250 g. Parkinsonism was modeled by subcutaneous administration of rotenone for 10 days at a dose of 2.5 mg / kg. To confirm the development of the pathology, motor coordination tests and histological staining of the cerebral cortex and striatum with hematoxylin and eosin were used. The oxidative status was analyzed based on the levels of conjugated dienes, carbonyl amino acid residues in proteins, and α-tocopherol. The enzyme activity was studied spectrophotometrically by the formation of NADPH. Real-time PCR was used to analyze the level of gene mRNA.

Results. During the study, an increase in serum and brain concentrations of conjugated dienes, carbonyl amino acid residues, and α-tocopherol was observed in the experimental group of rats compared to the controls. It could be associated with the redistribution of this compound between tissues during pathology development. The animals with experimental parkinsonism, in addition, were characterized by a decrease in the mRNA level of the Sod1, Gpx1, Gsr, Gsta2, Nfe2l2, and Foxo1 genes, as well as the activity of G6PDH and NADP-IDH. In the rats with experimental parkinsonism, a negative correlation of NADPH-IDH activity in the brain with serum α-tocopherol level and a positive correlation with Gpx1 and Foxo1 mRNA levels in the striatum were found. The level of oxidatively modified proteins in the brain of the animals with PD was negatively correlated with the concentration of Gsta2 mRNA in the striatum, while the specific activity of G6PDH in the serum was characterized by the positive relationship with grip strength.

Conclusion. The data obtained indicate that the inhibition of transcription of the genes encoding antioxidant enzymes and regulatory factors Nrf2 and Foxo1 contributed significantly to the development of oxidative stress in PD. A decrease in the activity of G6PDH and NADP-IDH led to a decrease in the availability of NADPH, which is a limiting factor in the functioning of the glutathione antioxidant system. Obviously, the inhibition of G6PDH and NADP-IDH was also an important pathogenic factor in the progression of the pathology. Along with a decrease in the content of antioxidant gene mRNA in the brain tissues, the level of α-tocopherol increased in the rats with parkinsonism, which could be the result of an imbalance in the functioning of antioxidant system.
The cytokine profile in obesity and asthma in children
Authors: Tarabrina A. A. , Ogorodova L. M. , Samoilova Yu. G. , Fedosenko S. V. , Fedorova O. S. , Petrov V. A. , Podchinenova D. V. , Boyko A. S.
Published: July 2023

Background. Childhood obesity is one of the pressing problems in modern healthcare, since it is associated with a high risk of non-communicable diseases, such as bronchial asthma (BA). The aim. To determine the features of cytokine profiles in children with and without BA, depending on body weight and visceral fat area.

Materials and methods. At the first stage, 506 Tomsk schoolchildren underwent anthropometry with the calculation of the body mass index (BMI) and measurement of the visceral fat area (VFA) using the InBody 770 analyzer. Fiftyone (51) children from the first stage were included in the second clinical and diagnostic stage. The children were divided into four clinical groups: “Obesity” (n = 17), “Visceral Obesity” (n = 7), “Asthma” (n = 15), and “Healthy Children” (n = 12). In all study participants, the levels of interleukin (IL)-6, IL-8, IL-4, IL-10, and immunoglobulin (Ig) E in the blood serum were determined by the multiplex assay (MagPix and Luminex 200 c analyzers). Statistical data analysis was carried out using the Statistica 10.0 software package and the 4.2.2 version of R.

Results. The levels of IL-10 in the “Asthma” (p < 0.006) and “Obesity” (p < 0.008) groups were significantly higher than in the “Visceral Obesity” group. Significantly higher levels of IL-8 were found in patients with asthma (p < 0.003) and obesity (p < 0.003) compared to the “Visceral Obesity” group. Higher concentrations of IL-6 were found in the “Asthma” (p < 0.001) and “Obesity” (p < 0.028) groups compared to the “Visceral Obesity” group.

Conclusion. Similar upward changes in IL-6, IL-8, and IL-10 in children with asthma and obesity without a history of asthma may explain the contribution of obesity to a risk of asthma in children, possibly through excessive production of these proinflammatory cytokines that contribute to the implementation of Th2-mediated allergic inflammation.
Migration of polyphenols from natural and microagglomerated cork stoppers to hydroalcoholic solutions and their sensory impact
Authors: Gancel Anne-Laure , Jourdes Michaël , Pons Alexandre , Teissedre Pierre-Louis
Published: July 2023

During bottling aging, the wine comes into contact with the cork stopper due to the horizontal position of the bottle. The release of compounds, such as cork phenolic compounds, thus take place between the cork and the wine, depending on the type of cork stopper and the surface treatments applied. Many publications describe the extraction of these phenolic compounds in wine or hydroalcoholic solutions from natural corks, but few address microagglomerated corks, which are increasingly used by winemakers to seal their bottles. The aim of this study was therefore to compare the polyphenols, mainly hydrolysable tannins, transferred from natural and microagglomerated corks treated with supercritical CO2 into hydroalcoholic solutions. For this purpose, polyphenols released in macerates of natural and microagglomerated cork stoppers were identified and quantified by HPLC-DAD-ESI-QQQ. Suberic acid was also quantified. In this study, despite the high intra-“natural cork stopper” variability, significant differences were found between both types of stoppers for all polyphenols, the agglomerated corks releasing significantly less polyphenols; i.e., 25 times less. In contrast, suberic acid was extracted from both types of corks in similar concentrations; therefore, its extractability was not impacted by the type of stopper. A sensory profile was also carried out on the macerates. Macerates of natural cork stoppers were perceived with notes of “cardboard, dust, plank, wood” and “cork taint” significantly higher than supercritical CO2 treated microagglomerated cork stopper macerates. Moreover, the natural cork macerate with the highest content in polyphenol was perceived as being more bitter than that of microagglomerated cork stoppers.
A Review of Imaging Methods and Recent Nanoparticles for Breast Cancer Diagnosis
Authors: Aminolroayaei Fahimeh , Shahbazi-Gahrouei Saghar , Khorasani Amir , Shahbazi-Gahrouei Daryoush
Published: July 2023

Breast cancer is the foremost common in women, and its early diagnosis will help treat and increase patients' survival. This review article aims to studies on recent findings of standard imaging techniques and their characteristics for breast cancer diagnosis and recent nanoparticles (NPs) which are used for breast cancer detection. Herein, The search was performed in the literature through scientific citation websites, including Google Scholar, PubMed, Scopus, and Web of Science until May 2023. A comprehensive study on different imaging modalities and NPs for breast cancer diagnosis is reviewed, and their successes, challenges, and limitations are discussed.
Recent Developments on Colorimetric and Dual Colorimetric/Fluorimetric Enzymatic Biosensors for the Detection of Pesticides in Food
Authors: Gaudin Valérie
Published: July 2023

Pesticides are chemical products are used to protect crops to prevent or eliminate undesirable organisms. Pesticides can contaminate continental waters, air, soil and food products. The presence of pesticide residues must therefore be monitored in water and food using sensitive, reliable and broad-spectrum analytical methods, as there is a huge variety of pesticides. Biosensors are one of the screening methods with great potential for detecting residues below the maximum residue limits. The different sensing principles of enzymatic biosensors for pesticide analysis will be described. This review highlights the great potential of colorimetric, enzymatic biosensors for detecting pesticide residues in water and food. Moreover the development of dual colorimetric and fluorimetric sensors during the past years is presented. These methods are most often based on the enzyme acetylcholinesterase, whose activity is inhibited by pesticides. The different approaches used in the development of these biosensors will be detailed, based on different chemical substrates, fluorophores and nanomaterials. The advantages and disadvantages of each approach will be discussed. Finally, the development prospects for improving these biosensors will be presented.
Insurtech Revolution in the Insurance Sector: A Comprehensive Review of the Transformational Impact and the Lemonade Case Study
Authors: La Barbera Salvatore
Published: July 2023

The insurance sector has undergone a transformative shift with the emergence of Insurtech, integrating technological innovations into the industry. This review aims to provide a comprehensive overview of the impact of Insurtech on the insurance sector, focusing on the case study of Lemonade. By placing the study in the context of the broader insurance landscape, the review explores the significance and relevance of this transformation. The article analyzes Lemonade's unique business model and its departure from traditional insurance practices. Furthermore, it examines the implications of Lemonade's approach on the industry and the challenges it faces. Through this analysis, the review sheds light on how Insurtech and the transformation of the insurance sector are redefining insurance services and consumer experiences. The future implications of these trends for insurance companies, consumers, and the industry as a whole are also explored. In summary, this review provides valuable insights into the transformative power of Insurtech, emphasizing the importance of technological advancements and innovative approaches in shaping the future of the insurance sector.
Inhibition of miR-25 Ameliorates Cardiac Dysfunction and Fibrosis by Restoring KLF4 Expression
Authors: Lee Choulong , Cho Sunghye , Jeong Dongtak
Published: July 2023

Cardiac hypertrophy is an adaptive response to various pathological insults including hypertension. However, sustained hypertrophy can cause impaired calcium regulation, cardiac dysfunction, and remodeling, accompanied by cardiac fibrosis. Our previous study identified miR-25 as a regulator of SERCA2a, and that inhibition of miR-25 improved cardiac function and reduced fibrosis by restoring SERCA2a expression in a murine heart failure model. However, the precise mechanism underlying the reduction of fibrosis by miR-25 inhibition remains unclear. Therefore, we postulate that miR-25 may have additional targets that contribute to regulating cardiac fibrosis. Using in silico analysis, Krüppel-like factor 4 (KLF4) was identified as an additional target of miR-25. Further experiments confirmed that KLF4 was directly targeted by miR-25 and that its expression was reduced by long-term treatment with Angiotensin II, a major hypertrophic inducer. Subsequently, treatment with a miR-25 inhibitor alleviated the cardiac dysfunction, fibrosis, and inflammation induced by Angiotensin II. These findings indicate that inhibiting miR-25 not only enhances calcium cycling and cardiac function via SERCA2a restoration but also reduces fibrosis by restoring KLF4 expression. Therefore, targeting miR-25 may be a promising therapeutic strategy for treating hypertensive heart diseases.
Investigation of Groundwater Aquifer Using Electrical Resistivity Method Wenner-Schlumberger Array Mattoangin Village, Bantimurung District, Maros Regency
Authors: Syafnur Aswar , Jibran Haidir , Tonapa William Desmond , Sae Ashar , Nurdin Nur Hidayat
Published: July 2023

Groundwater as a source of clean water which is very important in fulfilling the needs of humans is considered suitable as the main alternative. Layers investigation of soil that is permeable to water (aquifer) in Mattoangin Village, Bantimurung District, Maros Regency aims to obtain 2D model map of the distribution of groundwater below the surface. The presence of groundwater stored in aquifers can be explored by geophysical methods. The Wenner-Schlumberger array has a good resolution so it is deemed suitable for aquifers. The measurement data was processed using Res2DInv software. The exploration resulted in a 2D cross-sectional model of the subsurface resistivity. Based on the results of measurements and data processing, the groundwater aquifer which has the potential to have resistivity values of 9.73-32.7 Ωm on track 1, resistivity values of 6.24-32 Ωm is on track 2 with a depth of 6 - 10 m and resistivity values of 5.68-33, 6 Ωm on track 3 with a depth of 6 - 8 Ωm.
Pengaruh Pembiayaan dalam Era Presiden Jokowi dan SBY pada Tahun 2010-2019 terhadap Pemerataan Peningkatan Pembangunan Jalan di Indonesia
Authors:   Program Studi Magister Perencanaan Ekonomi dan Kebijakan Pembangunan, Fakultas Ekonomi dan Bisnis, Universitas Indonesia, Prasedyawati Dhini Rizky , Soesilo Nining I ,   Departemen Ilmu Ekonomi, Fakultas Ekonomi dan Bisnis, Universitas Indonesia
Published: July 2023

Studi ini bertujuan menemukan bukti empiris secara kuantitatif tentang Pengaruh Pembiayaan Dalam Era Presiden Jokowi Dan SBY Pada Tahun 2010-2019 Terhadap Pemerataan Peningkatan Pembangunan Jalan Di Indonesia. Analisis dilakukan dengan regresi data panel melalui metode common effect, dengan unit observasi yaitu 11 Provinsi di Indonesia dalam kurun waktu 10 tahun yaitu 2010-2019. Adapun yang menjadi variabel dependen dalam penelitian ini adalah panjang jalan nasional, sementara variabel independennya adalah APBN, Pinjaman Luar Negeri, Jumlah Penduduk, PDRB, dummy pemimpinan dan dummy kewilayahan. Setelah dilakukan analisis secara keseluruhan maka dapat dilihat bahwa panjang jalan nasional pada masa pemerintahan Jokowi berpengaruh secara positif dan signifikan terhadap pembangunan jalan nasional di Indonesia. Jika dilihat dari dummy kewilayahan semuanya berpengaruh positif dan signifikan di beberapa kepulauan seperti Pulau Sumatera, Pulau Jawa, Pulau Bali NTT, dan Pulau Papua Maluku.. Hal ini menandakan bahwa pemerataan pembangunan pada masa pemerintahan Jokowi berjalan dengan baik.
Dampak Peningkatan Kualitas Permukiman Kumuh Perdesaan terhadap Pengurangan Peluang Kejadian Bencana: Kasus Kebijakan Dana Desa di Indonesia
Authors:   Program Pascasarjana Ilmu Ekonomi Fakultas Ekonomi dan Bisnis Universitas Indonesia, Simanjuntak Ruth Agustina , Simanjuntak Ruth Agustina ,   Program Pascasarjana Ilmu Ekonomi Fakultas Ekonomi dan Bisnis Universitas Indonesia
Published: July 2023

Penelitian ini mencoba melihat dampak dari peningkatan kualitas permukiman kumuh terhadap pengurangan kejadian bencana banjir dan tanah longsor di tingkat desa di Indonesia. Dengan menggunakan pendekatan difference-in-differences (DID) pada model regresi logit, penelitian ini menganalisis pengaruh kebijakan dana desa di 24.343 desa di Indonesia dalam kurun waktu 2006-2018. Hasilnya menunjukkan bahwa setelah kebijakan dana desa diimplementasikan, peluang terjadinya kejadian bencana pada kelompok treatment, yaitu desa-desa yang memiliki tingkat permukiman kumuh relatif tinggi adalah 0,761 kali lebih rendah dibandingkan dengan kelompok kontrol, yaitu desa-desa yang memiliki tingkat permukiman kumuh relatif rendah dengan tingkat signifikansi 1%. Hal ini menunjukkan bahwa pembangunan dan atau peningkatan kualitas infrastruktur di permukiman kumuh perdesaan memiliki efek yang signifikan dalam mengurangi peluang terjadinya kejadian bencana.
Grammatikatanítás a magyar szakos tanárjelöltek szemszögéből
Authors: Bartha Blanka
Published: July 2023

A magyartanárok viszonya a klasszikus leíró nyelvtani ismeretek tanításához mindmáig ambivalens. Ebből kiindulva a jelen tanulmány célja, hogy számot adjon a magyartanárjelöltek grammatikatanításhoz fűződő viszonyáról, az általuk szívesen tanított klasszikus leíró nyelvtani témakörökről és a magyar grammatikai témájú anyanyelvi tanóráikon leginkább kedvelt módszerekről és munkaformákról. A kutatás kétféle adatgyűjtési módszerre támaszkodik: egy 80 magyartanárjelölttel készült fókuszcsoportos interjúra és egy általuk kitöltött anonim, online kérdőívre. Az eredmények azt mutatják, hogy a végzős tanárjelöltek kevésbé motiváltak a grammatikai ismeretek tanításában, mint a korábbi kutatások résztvevői. Tanulmányaik során nehézségekbe ütköznek a leíró nyelvtani ismeretek elsajátításakor és a későbbi átadásakor is. A tanulmány összegzi a klasszikus leíró nyelvtan tanításával kapcsolatos tapasztalatokat, és a tanári képzésükben való paradigmaváltás szükségességét hangsúlyozza.
Encountering Humanity’s Dark Side: A Conversation about Perpetrators
Authors: Üngör Uğur Ümit
Published: July 2023

An interview conducted by Uğur Üngör with Alexander L. Hinton and A. C. G. M. Robben about their new book, Perpetrators: Encountering Humanity’s Dark Side (Stanford University Press, 2023)
State Violence in Narcotic Drug Governance: A Call for Harm Reduction and Human Rights Protection
Authors: Regilme Salvador Santino
Published: July 2023

This reflection piece sheds light on expanded state violence in global narcotic governance, offering valuable insights to perpetrator studies. It expands the focus by acknowledging the state as a collective perpetrator within the framework of global narcotic regulation. With its near-monopoly on the use of force, the state possesses significant resources to inflict violence on citizens, leading to increased number of civilian fatalities, suffering, and other forms of physical integrity rights abuses. Additionally, this piece highlights the role of structural factors in facilitating state violence and the spread of narcotic drugs, emphasizing socioeconomic inequalities and systemic discrimination perpetuated by a militaristic approach to narcotic politics. Lastly, it emphasizes the disproportionate impact of state violence and drug policies on marginalized communities, urging an examination of how coercive state agencies deliberately target minoritized groups.
Editorial
Authors: Perra Emiliano
Published: July 2023

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‘I could have slapped myself’: The Ethics of the Bystander Perspective in Sebastian Haffner’s Memoir
Authors: Pilsworth Ellen
Published: July 2023

The second half of Sebastian Haffner’s posthumously published memoir, Geschichte eines Deutschen, describes Haffner’s experiences of the first years of Nazi rule. In my reading of key passages, I consider how the text works to highlight the discrepancy between Haffner’s thoughts and actions as he is increasingly compelled to accept and even participate in Nazi activities, despite his hatred of Nazism. By presenting his case as typical, and drawing the reader into a sense of intimacy and trust with Haffner, his text elicits empathy for the ‘ordinary Germans’ who unwillingly became part of what Fulbrook calls the ‘bystander society’ under Nazism. After analysing the memoir, I consider its reception in the German and English-speaking worlds at the time of publication, and reflect on the ethical implications of empathising with Haffner’s bystander perspective.
Jihad and Interpretation of Religious Texts on Female Terrorists in Indonesia
Authors: Atabik Ahmad , Muhtador Moh
Published: July 2023

The involvement of women in terrorism circles has led to the emergence of a brand-new terrorist map of the terrorism fight in Indonesia, where women had previously played a private role solely. Their involvement in public spaces in terrorism circles is closely associated with patriarchal culture and transformation in the concept of hijrah and qital as a means of jihad. This paper aims to explore the three domains of women's attempts at terror as a series of struggles; it includes defining women's weaknesses and disadvantages by patriarchal circles, using media to encourage women's emotional enthusiasm in the circle of terror, and interpreting hijrah and qital as justification for jihad movement which becomes a spirit for women to commit terrors. The data in this study came from observations, interviews with two female terrorists, one terrorist advisor, and one ex-convict, as well as the discourse of terror-related web publications. This study reveals that male terrorists exploit patriarchal culture to establish religious authority in their organizations. In addition, virtual media is highly effective in spreading propaganda for women’s involvement in the struggle domain for two reasons. First, it broadcasted by providing fatwas on the women’s consent to fight based on historical background. Second, it propagated by offering new religious interpretations of the terms hijrah and qital as jihad media tailored to the terrorist organizations’ missions and goals.
Análisis de las marcas publicitarias como identificadores de distopía: presencia de marca en Black Mirror
Authors: Guerrero Navarro Daniel
Published: July 2023

La presente investigación se centra en conocer la presencia de la publicidad emplazada y su relevancia para el discurso narrativo a través de un análisis de contenido sobre la presencia del emplazamiento de marcas en los 23 episodios de las cinco temporadas emitidas de la serie Black Mirror, producción de Netflix, con un metraje total cercano a 1.400 minutos de revisión. El estudio muestra que existen 773 apariciones de marcas (reales y ficticias), con 40 minutos y 45 segundos de presencia. El estudio afirma que las marcas emplazadas por las exigencias de la producción ofrecen además un relevante valor narrativo para la transmisión de realismo distópico que desean los autores, optimizando la creatividad en la relación entre la narración, el producto mostrado y el receptor pasivo o activo, pero todo ello, siempre dentro de los límites de regulación audiovisual existentes y acercando las tendencias que la tecnología y la publicidad pueden ofrecer en corto plazo a las series de televisión y marcas para crear acciones publicitarias programáticas personalizadas.
‘Everybody Wants to Be My Enemy’: Popular Music and Transmediality in Arcane
Authors: Febrer Eulalia
Published: July 2023

The popularization of Arcane, released in 2021 on Netflix, has gone hand in hand with the billboard success by Imagine Dragons, Enemy. The series' soundtrack is rooted in previous musical commodities produced by Riot Games, whose growing interest in expanding the e-sports market through transmedia strategies has been reflected in the increasing weight of its non-playable products. The series proposes a confrontation between the members of two socioeconomically contrasting cities, which, along with the relationship between its protagonists and the selected music for its illustration, brings the imagined reality of the show closer to the daily experience of its audience. The suggested analysis and the collection of the participants' experiences in the transmedia phenomenon shows how the strategy followed by the developer has effectively impacted the consumption of both the video game and the music of the artists involved in the confection of its Original SoundTrack.
Preservation of Soft-Bodied Organisms in Early Cambrian Carbonates
Authors: Marusin V.V. , Bykova N.V.
Published: July 2023

—Preservation of soft-bodied organisms as casts is common in the Ediacaran fossil record and extremely rare in Cambrian rocks. Among the factors, limiting fossilization of soft tissues, there is bioturbation–sediment disturbance by burrowing organisms. It is the emergence of burrowing metazoans and associated sediment bioturbation that is thought to be one of the major causes for the disappearance of Ediacaran soft-bodied organisms from the fossil record around ~540 Ma. Here, we study an assemblage of fossils preserved as casts in the Fortunian carbonates of the Olenek Uplift (northeastern Siberian Platform) in association with a typical Fortunian ichnoassemblage. The overall morphology and preservation of the fossils reveal that they comprise microbially induced sedimentary structures and soft-bodied holdfasts. The latter are vaguely reminiscent of some Ediacaran holdfasts, though it is unlikely that they include their phylogenetic descendants. Three-dimensional preservation of the studied fossils was caused by authigenic crystallization of calcite and its further early-diagenetic dolomitization. Our study confirms the critical importance of specific environmental conditions ensuring preservation of soft-bodied organisms as three-dimensional molds and casts. This unique interplay of environmental factors became rare in the Cambrian Period, which was caused by intensification and expansion of bioturbation in marine basins.
Optimalisasi Peran KSPPS BMT Beringharjo KCP Dolopo dalam Meminimalisir Praktek Rentenir di Masyarakat
Authors: Nurnalia Reta , Ruliq Suryaningsih
Published: July 2023

Baitul Maal wat Tamwil (BMT) is a microfinance institution that operates on Sharia principles/profit sharing, which has the aim of being able to grow micro-enterprises in order to elevate the degree and dignity and defend the interests of the poor. The research method used in this research is a qualitative method with a descriptive descriptive approach. With data collection techniques in the form of interviews and using descriptive qualitative analysis techniques. The conclusion of this study shows. The conclusions from this study show that optimizing the role of KSPPS BMT Beringharjo in minimizing the practice of moneylenders in the community is in accordance with Sudarsono's theory, but still needs improvement in efforts to distance the community from non-sharia economic practices such as providing outreach to the community.