bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Mutation in LARP7 in Two Iranian Consanguineous Families with Syndromic Intellectual Disability and Facial Dysmorphism
Authors: Kazemi Goli , Peymani Fatemeh , Mohseni Marzieh , Zare Ashrafi Farzane , Arzhangi Sanaz , Ardalani Fariba , Aghakhani Moghaddam Fatemeh , Kahrizi Kimia , Najmabadi Hossein
Published: December 2020

Background: Recently, we have reported mutations in LARP7 gene, leading to neurodevelopmental disorders (NDDs), the most frequent cause of disability in children with a broad phenotype spectrum and diverse genetic landscape. Methods: Here, we present two Iranian patients from consanguineous families with syndromic intellectual disability, facial dysmorphism, and short stature. Results: Whole-exome sequencing (WES) revealed a novel homozygous stop-gain (c.C925T, p.R309X) variant and a previously known homozygous acceptor splice-site (c.1669-1_1671del) variant in LARP7 gene, indicating the diagnosis of Alazami syndrome. Conclusion: These identified variants in patients with Alazami syndrome were consistent with previously reported loss of function variants in LARP7 and provide further evidence that loss of function of LARP7 is the disease mechanism.
Unsafe Injection Is Associated with Higher HIV Testing after Bayesian Adjustment for Unmeasured Confounding
Authors: Navadeh Soodabeh , Mirzazadeh Ali , McFarland Willi , Coffin Phillip , Chehrazi Mohammad , Mohammad Kazem , Nazemipour Maryam , Mansournia Mohammad Ali , McCandless Lawrence C , Page Kimberly
Published: December 2020

Background: To apply a novel method to adjust for HIV knowledge as an unmeasured confounder for the effect of unsafe injection on future HIV testing. Methods: The data were collected from 601 HIV-negative persons who inject drugs (PWID) from a cohort in San Francisco. The panel-data generalized estimating equations (GEE) technique was used to estimate the adjusted risk ratio (RR) for the effect of unsafe injection on not being tested (NBT) for HIV. Expert opinion quantified the bias parameters to adjust for insufficient knowledge about HIV transmission as an unmeasured confounder using Bayesian bias analysis. Results: Expert opinion estimated that 2.5%–40.0% of PWID with unsafe injection had insufficient HIV knowledge; whereas 1.0%–20.0% who practiced safe injection had insufficient knowledge. Experts also estimated the RR for the association between insufficient knowledge and NBT for HIV as 1.1-5.0. The RR estimate for the association between unsafe injection and NBT for HIV, adjusted for measured confounders, was 0.96 (95% confidence interval: 0.89,1.03). However, the RR estimate decreased to 0.82 (95% credible interval: 0.64, 0.99) after adjusting for insufficient knowledge as an unmeasured confounder. Conclusion: Our Bayesian approach that uses expert opinion to adjust for unmeasured confounders revealed that PWID who practice unsafe injection are more likely to be tested for HIV – an association that was not seen by conventional analysis.
Risk Factors, Clinical Symptoms, Laboratory Findings and Imaging of Pregnant Women Infected with COVID-19 in North of Iran
Authors: Kazemi Aski Soudabeh , Sharami Seyedeh Hajar , Hosseinzadeh Fatemeh , Hesni Ezat , Dalil Heirati Seyedeh Fatemeh , Ghalandari Maryam , Mousavi Atefeh
Published: December 2020

Background: Due to the physiological changes in the body during pregnancy, the increased susceptibility to viral infections during this period and also the high prevalence of coronavirus disease 2019 (COVID-19) in the Guilan province, Iran, this study aimed to evaluate risk factors, clinical symptoms, laboratory findings and imaging of pregnant mothers with COVID-19. Methods: In this descriptive study, 70 pregnant women aged 17–41 years with COVID-19 who were hospitalized from early March to late April 2020 were enrolled. Sampling was performed by census and from all hospitals in Guilan. The research instruments included a researcher-made questionnaire, including demographic characteristics, clinical symptoms, medical examinations, and paraclinical results. Data were analyzed with SPSS version 16. Frequency and percent were used to describe qualitative variables; for quantitative variables, if they were normally distributed, mean and standard deviation were used, and if they were non-normal, median and interquartile range (IQR) were used. Results: The most severe symptoms recorded in mothers at the time of hospitalization were fever (47%), shortness of breath (16%) and cough (15%), respectively. One of 68 (1%) was in the severe stage of the disease and two mothers (2%) were in critical condition and admitted to the intensive care unit and finally died. Fifty-five of 66 women (83%) had lymphopenia, 22 of 42 (52%) tested positive on PCR, and 30 of 33 (90%) had an increase in lactate dehydrogenase (LDH) levels.Results showed that 15 of 32 patients who gave birth had preterm delivery (46%). Conclusion: The most common manifestations of the disease in pregnant women were fever, cough and shortness of breath, and in some cases muscle pain. The most common laboratory finding in infected mothers was lymphopenia. Complications of pregnancy and childbirth in women included an increase in cesarean delivery.
Mesenchymal Stromal Cells Derived Conditioned Medium in Pulmonary Fibrosis: A Systematic Review and Meta-analysis
Authors: Ali Kosar Mohamed , Fattah Fattah Hama Rahim , Omar Shirwan Hamasalh , Gubari Mohammed I M , Yousefifard Mahmoud , Hosseini Mostafa
Published: December 2020

Background: A definitive conclusion on the efficacy of mesenchymal stromal cells-derived conditioned medium (MSCs-CM) in pulmonary fibrosis has not yet been reached. Therefore, the present meta-analysis intends to investigate the efficacy of MSCs-CM administration on improvement of pulmonary fibrosis. Methods: An extensive search was performed on the Medline, Embase, Scopus and Web of Science databases by the end of August 2019. Outcomes in the present study included pulmonary fibrosis score, lung collagen deposition, lung collagen expression, transforming growth factor β1 (TGF-β1) expression and interleukin-6 expression. Finally, the data were pooled and an overall standardized mean difference (SMD) with a 95% confidence interval (CI) was reported. Results: Data from seven studies were included. Analyses showed that administration of MSCs-CM significantly improved pulmonary fibrosis (SMD = -2.36; 95% CI: -3.21, -1.51). MSCs-CM administration also attenuated lung collagen deposition (SMD = -1.70; 95% CI: -2.18, -1.23) and decreased expression of type I collagen (SMD = -6.27; 95% CI: -11.00, -1.55), type III collagen (SMD = -5.16; 95% CI: -9.86, -0.47), TGF- β1 (SMD = -3.36; 95% CI: - 5.62, -1.09) and interleukin-6 (SMD = -1.69; 95% CI: - 3.14, -0.24). Conclusion: The present meta-analysis showed that administration of MSCs-CM improves pulmonary fibrosis. It seems that the effect of MSCs-CM was mediated by reducing collagen deposition as well as inhibiting the production of inflammatory chemokines such as TGF-β1 and interleukin 6 (IL-6). Since there is no evidence on the efficacy of MSCs-CM in large animals, further studies are needed to translate the finding to clinical studies.
A Proposed Regulatory Review Model to Support the South African Health Products Regulatory Authority to Become a More Efficient and Effective Agency
Authors: Keyter Andrea , Salek Sam , Banoo Shabir , Walker Stuart
Published: December 2020

Background: National regulatory agencies of various sizes and maturity levels, including the South African Health Products Regulatory Authority (SAHPRA), have had to revise systems and re-engineer processes in order to adapt to the new regulatory environment and increase the effectiveness of regulatory operations. This study aimed to develop a new regulatory review model for improved regulatory performance, underpinned by the parameters of the World Health Organization Global Benchmarking Tool (WHO GBT) that support strengthening of regulatory systems. Methods: A new enhanced model for regulatory review, was developed based on the key recommendations from 6 studies, previously conducted by the authors, that were identified as fundamental elements in enhancing regulatory performance. The elements selected to define the new regulatory review model were endorsed through the integration of the parameters of the WHO GBT that, when embedded within regulatory systems, support enhanced regulatory performance. Results: Opportunities for improvement in regulatory performance were identified and include quality measures; monitoring and evaluating review times; a risk-based evaluation; transparency and communication; and training and education. An improved model for the South African regulatory review and benefit-risk (BR) assessment supported by quality decision-making was proposed as well as recommendations for the application of risk-stratification strategies, strengthening of reliance networks, reinforcing good regulatory practices (GRPs) and enhancing transparency. Conclusion: If implemented the proposed improved regulatory model may pave the way towards more efficient and transparent, streamlined review processes, coupled with increased consistency, evidence-based decision-making practices, reduced timelines and improved patients’ access to new medicines in South Africa.
Measuring Organizational Readiness for Implementing Change in Primary Care Facilities in Rural Bushbuckridge, South Africa
Authors: Leslie Hannah H. , West Rebecca , Twine Rhian , Masilela Nkosinathi , Steward Wayne T. , Kahn Kathleen , Lippman Sheri A.
Published: December 2020

Meaningful gains in health outcomes require successful implementation of evidence-based interventions. Organizations such as health facilities must be ready to implement efficacious interventions, but tools to measure organizational readiness have rarely been validated outside of high-income settings. We conducted a pilot study of the organizational readiness to implement change (ORIC) measure in public primary care facilities serving Bushbuckridge Municipality in South Africa in early 2019. We administered the 10-item ORIC to 54 nurses and lay counsellors in 9 facilities to gauge readiness to implement the national Central Chronic Medicine Dispensing and Distribution (CCMDD) programme intended to declutter busy health facilities. We used exploratory factor analysis (EFA) to identify factor structure. We used Cronbach alpha and intraclass correlation (ICC) to assess reliability at the individual and facility levels. To assess validity, we drew on existing data from routine clinic monitoring and a 2018 quality assessment to test the correlation of ORIC with facility resources, value of CCMDD programme, and better programme uptake and service quality. Six items from the ORIC loaded onto a single factor with Cronbach’s alpha of 0.82 and ICC of 0.23. While facility ORIC score was not correlated with implementation of CCMDD, higher scores were correlated with facility resources, perceived value of the CCMDD program, patient satisfaction with wait time, and greater linkage to care following positive HIV testing. The study is limited by measuring ORIC after programme implementation. The findings support the relevance of ORIC, but identify a need for greater adaptation and validation of the measure.
Universal Health Coverage for Non-communicable Diseases and Health Equity: Lessons From Australian Primary Healthcare
Authors: Fisher Matthew , Freeman Toby , Mackean Tamara , Friel Sharon , Baum Fran
Published: December 2020

Background: Universal health coverage (UHC) is central to current international debate on health policy. The primary healthcare (PHC) system is crucial to achieving UHC, in order to address the rising incidence of non-communicable diseases (NCDs) more effectively and equitably. In this paper, we examine the Australian case as a mature system of UHC and identify lessons for UHC policy to support equity of access to PHC and reduce NCDs. Methods: Our qualitative research used policy mapping and monitoring and 30 key informant interviews, and applied policy theory, to investigate the implementation of Australian PHC policy between 2008 and 2018. Results: Although the Australian PHC system does support equity of access to primary medical care, other ideational, actor-centred and structural features of policy detract from the capacities of the system to prevent and manage NCDs effectively, deliver equity of access according to need, and support equity in health outcomes. These features include a dominant focus on episodic primary medical care, which is a poor model of care for NCDs, and an inequitable distribution of these services. Also, a mixed system of public and private insurance coverage in PHC contributes to inequities in access and health outcomes, driving additional NCD demand into the health system. Conclusion: Countries aiming to achieve UHC to support health equity and reduce NCDs can learn from strengths and weaknesses in the Australian system. We recommend a range of ideational, actor-centred and structural features of UHC systems in PHC that will support effective action on NCDs, equity of access to care according to need, and equity in health outcomes across geographically and ethnically diverse populations.
DESIGN OF KOST RENT INFORMATION SYSTEM
Authors: Helling Lydia Salvina , Hasanudin Hasanudin , Wahyudi Endang , Ajusta A.A.Gede
Published: December 2020

Rumah Kost Hj. Gaby is one of the many boarding houses for rent around industrial areas and offices in the Tg. Priok area, North Jakarta. This boarding house still uses a board in front of the house to indicate that the house is rented out for boarding. This method is less effective in promoting the boarding house because prospective tenants must accidentally pass and see the promotion board. The down payment for boarding and monthly rent still has to meet directly with the owner of the boarding house so that it requires special time. The boarding rental information system that is designed is expected to help prospective tenants or tenants to make more practical order and payment transactions, in addition to helping boarding owners tidy up their boarding room rental management The methods used in this research are: interviews, observation, and literacy studies for data collection. Meanwhile, the model used for software development uses the Rapid Application Development Model (RAD). The results of this study are expected to assist boarding owners in promoting their boarding houses and also provide a more effective way of conducting transactions related to the boarding houses.
SMOOTHING IN NEURAL NETWORK FOR UNIVARIAT TIME SERIES DATA FORECASTING
Authors: Syamsiah Nurfia Oktaviani , Purwandani Indah
Published: December 2020

Time series data is interesting research material for many people. Not a few models have been produced, but very optimal accuracy has not been obtained. Neural network is one that is widely used because of its ability to understand non-linear relationships between data. This study will combine a neural network with exponential smoothing to produce higher accuracy. Exponential smoothing is one of the best linear methods is used for data set transformation and thereafter the new data set will be used in training and testing the Neural Network model. The resulting model will be evaluated using the standard error measure Root Mean Square Error (RMSE). Each model was compared with its RMSE value and then performed a T-Test. The proposed ES-NN model proved to have better predictive results than using only one method.
EDITORIAL
Authors: Colacrai Miryam , Lechini Gladys
Published: December 2020

"Esta nueva entrega de los Cuadernos de Política Exterior Argentina (CUPEA) nos encuentra en una situación única para todos los habitantes de la Tierra: la primera cuarentena global de la historia, en aislamiento total desde hace más de dos meses, por la presencia del COVID-19 y sus efectos posibles y reales sobre la vida de toda la humanidad..."
Proceso constituyente en Chile
Authors: Gascón Felip , Tórtora Hugo
Published: December 2020

"Contextualizar el actual proceso constituyente en Chile y sus posibles desenlaces, nos impone la necesidad de abordar una más larga duración histórica sobre la emergencia de un nuevo ciclo de protesta social que, si bien se fue incubando en forma de múltiples resistencias al modelo neoliberal implantado, logró superar la fragmentación social heredada de la dictadura cívico-militar y reproducida durante el largo período de postdictadura, hasta articularse como una gran plataforma de resistencia reivindicativa con la revuelta popular del 18 de octubre de 2019 (18-O)..."
Completamiento de series temporales de niveles freáticos en un área deprimida de la llanura bonaerense
Authors: Zimmermann Erik
Published: December 2020

Se presenta como objetivo el completamiento de registros temporales de niveles freáticos someros en un sector deprimido perteneciente a la cuenca del Arroyo del Azul (provincia de Buenos Aires), en el marco de una modelación matemática de la hidrología subterránea. Los registros completados conforman la condición de contorno aguas arriba del dominio de modelación. Se contemplaron diferentes series temporales para correlacionarlas con los niveles freáticos: a) anomalías acumuladas de precipitación, b) anomalías gravimétricas (misión satelital GRACE) y c) anomalías acumuladas hidrológicas (diferencia entre la precipitación y la evapotranspiración potencial). De los seis pozos freatimétricos seleccionados para el análisis y para el período donde se presentan las series en forma completa (oct 2014- abr 2016) se deduce que las anomalías de precipitación (a) presentan los coeficientes de correlación r más bajos y fue descartada como serie análoga. Las anomalías gravimétricas mensuales (b), Gravity Recovery and Climate Experiment (GRACE) misión conjunta de la NASA y el Centro Aeroespacial Alemán (DLR) presentaron correlaciones buenas, con valores de r entre 0.624 y 0.798, aunque la serie suministrada se discontinúa desde 2017. Las anomalías hidrológicas acumuladas, que fueron calculadas a escala diaria y retrasadas respecto los niveles un lagsemanal para mejorar las regresiones, presentaron correlaciones muy buenas, con r entre 0.861 y 0.894, fueron las seleccionadas como serie análoga de completamiento. Considerando la mejor disponibilidad de datos climáticos frente a los satelitales y en virtud de los buenos resultados alcanzados se recomienda el uso de esta metodología en sectores de niveles freáticos someros donde el proceso de evaporación puede considerarse una componente hidrológica de importancia.
evaluación formativa en la enseñanza de historia, geografía y ciencias sociales
Authors: Sánchez Sánchez Gerardo , Espinoza Cáceres Thalía , Gutiérrez Núñez Nicole , Letelier Contreras Oliver , Vergara Karenn Mora , Moraga Orellana Romina , Muñoz Vega Paulina
Published: December 2020

RESUMEN En nuestro sistema educativo la evaluación de los aprendizajes es una práctica centrada en resultados, y, por tanto, en su función social. Actualmente, el decreto 67/2018 plantea el desafío con una evaluación formativa que debe iniciar su implementación el año 2020. La investigación cualitativa basada en un estudio de casos múltiples, analiza cómo se implementa la evaluación formativa en la enseñanza primaria de Historia, Geografía y Ciencias Sociales, en colegios de la provincia de Talca. Los resultados confirman la presencia de una función pedagógica de la evaluación, condicionada por la estandarización del sistema educacional.
A zero-truncated discrete Akash distribution with properties and applications
Authors: Sium Simon , Shanker Rama
Published: December 2020

This study proposes and examines a zero-truncated discrete Akash distribution and obtains its probability and moment-generating functions. Its moments and moments-based statistical constants, including coefficient of variation, skewness, kurtosis, and the index of dispersion, are also presented. The parameter estimation is discussed using both the method of moments and maximum likelihood. Applications of the distribution are explained through three examples of real datasets, which demonstrate that the zero-truncated discrete Akash distribution gives better fit than several zero-truncated discrete distributions.
Spectrum assignment in linear systems with several commensurate lumped and distributed delays in state by means of static output feedback
Authors: Zaitsev V.A. , Kim I.G.
Published: December 2020

A linear control system defined by a stationary differential equation of nth order with several commensurate lumped and distributed delays in state is considered. In the system, the input is a linear combination of m variables and their derivatives of order not more than n−p and the output is a k-dimensional vector of linear combinations of the state and its derivatives of order not more than p−1. For this system, a spectrum assignment problem by linear static output feedback with commensurate lumped and distributed delays is studied. Necessary and sufficient conditions are obtained for solvability of the arbitrary spectrum assignment problem by static output feedback controller. Corollaries on stabilization of the system are obtained.
Stability of regular vortex polygons in Bose-Einstein condensate
Authors: Kilin A.A. , Artemova E.M.
Published: December 2020

We consider the problem of the stability of rotating regular vortex N-gons (Thomson configurations) in a Bose-Einstein condensate in a harmonic trap. The dependence of the rotation velocity ω of the Thomson configuration around the center of the trap is obtained as a function of the number of vortices N and the radius of the configuration R. The analysis of the stability of motion of such configurations in the linear approximation is carried out. For N⩽6, regions of orbital stability of configurations in the parameter space are constructed. It is shown that vortex N-gons for N > 6 are unstable for any parameters of the system.
On a linear autonomous descriptor equation with discrete time. II. Canonical representation and structural properties
Authors: Khartovskii V.E.
Published: December 2020

We consider a linear homogeneous autonomous descriptor equation with discrete time B0g(k+1)+∑mi=1Big(k+1−i)=0,k=m,m+1,…, with rectangular (in general case) matrices Bi. Such an equation arises in the study of the most important control problems for systems with many commensurate delays in control: the 0-controllability problem, the synthesis problem of the feedback-type regulator, which provides calming to the solution of the original system, the modal controllability problem (controllability to the coefficients of characteristic quasipolynomial), the spectral reduction problem and the synthesis problem observers for dual surveillance system. The main method of the presented study is based on replacing the original equation with an equivalent equation in the “expanded” state space, which allows one to match the new equation of the beam of matrices. This made it possible to study a number of structural properties of the original equation by using the canonical form of the beam of matrices, and express the results in terms of minimal indices and elementary divisors. In the article, a criterion is obtained for the existence of a nontrivial admissible initial condition for the original equation, the verification of which is based on the calculation of the minimum indices and elementary divisors of the beam of matrices. The following problem was studied: it is required to construct a solution to the original equation in the form g(k+1)=Tψ(k+1), k=1,2…, where T is some matrix, the sequence of vectors ψ(k+1), k=1,2,…, satisfies the equation ψ(k+1)=Sψ(k), k=1,2,…, and the square matrix S has a predetermined spectrum (or part of the spectrum). The results obtained make it possible to construct solutions of the initial descriptor equation with predetermined asymptotic properties, for example, uniformly asymptotically stable.
Chapter 6 - Warung makan – public kitchens at the epicentre of informality in Jakarta
Authors: Arciniegas Laura
Published: December 2020

In Jakarta’s kampung (slum neighbourhoods), warung makan are food outlets that offer traditional ‘homemade’ dishes (masakan rumah) on a daily basis. Eaters who frequent these commercial food outlets every day regard them as extensions of their households. Moreover, domestic activities are shifting towards warung makan, which are propitious to interactions between eaters and vendors within social networks bound by ties of neighbourliness, kinship, solidarity and trust.
Efek Kurkumin Pada Kunyit (Curcuma longa) Sebagai Pengobatan Kanker Lambung
Authors: Puteri Firantika Dias
Published: December 2020

Latar Belakang :. Kanker atau keganasan merupakan sekelompok penyakit yang ditandai dengan pertumbuhan yang tidak terkendali dan penyebaran sel-sel abnormal. Salah satu kanker yang masih menjadi masalah di dunia adalah kanker lambung. Kanker lambung merupakan salah satu penyumbang utama kematian yang tinggi di dunia, terutama pada kalangan pria di usia tua. Terdapat beberapa metode pengobatan yang biasa dilakukan, seperti pembedahan, radiasi dan kemoterapi. Pemilihan metode tersebut tergantung pada jenis dan stadium perkembangan tumor. Kemoterapi merupakan salah metode pengobatan pilihan, namun tingkat keberhasilan pengobatan ini terbatas karena adanya kemoresistensi. Tanaman herbal merupakan salah satu senyawa aktif yang dipercaya menjadi salah satu alternatif sebagai antikanker karena memiliki efek samping minimal. Salah satu tanaman yang dapat dimanfaatkan adalah kunyit (Curcuma longaI). Tujuan : mengetahui lebih lanjut tentang manfaat kunyit sebagai pengobatan kanker lambung. Metode : Metode yang digunakan oleh penulis adalah studi literatur dari berbagai jurnal nasional maupun internasional. Metode ini digunakan dengan tujuan menambah pengetahuan dan pemahaman mengenai topik yang dibahas dengan menyajikan materi yang telah diterbitkan dengan meringkas materi yang telah diterbitkan serta memberikan informasi fakta atau analisis baru dari tinjauan literatur yang relevan kemudian membandingkan hasil tersebut dalam artikel. Hasil : Senyawa kurkumin dari tanaman Curcuma longa dapat berperan dalam menghambat proliferasi sel kanker, antiinflamasi, penghambatan karsiogenik, immunomodulatory, antiestrogem dan antiangiogenesis. Perannya dalam tumorigenesis juga dimediasi melalui ekspresi gen yang menekan apoptosis, memediasi proliferasi, invasi dan angiogenesis. Kesimpulan : Kandungan kurkumin dalam kunyit dapat berperan sebagai antikanker seperti pada kanke r lambung
Distribusi Frekuensi Kejadian Postpartum Blues Pada Ibu Pascamelahirkan
Authors: Tarisa Nabilah , Octarianingsih Fonda , Ladyani Festy , Pramesti Woro
Published: December 2020

Postpartum depression pada ibu pascamelahirkan biasanya diawali dengan postpartum blues atau baby blues atau maternity blues. Jenis penelitian yang digunakan adalah deskriptif kuantitatif dengan menggunakan kuisioner data demografik dan kuesioner EPDS (Edinburgh Postpartum Depression Scale) sebagai data primer. Sampel meggunakan teknik total sampling dengan jumlah sampel sebanyak 40 responden. Data analisis digunakan untuk mengetahui distribusi frekuensi dan melihat hubungan antara karakteristik. Pada penelitian ini didapatkan pada 40 ibu pascamelahirkan terdapat 7 responden (17,5%) yang terdeteksi terkena postpartum blues, dan 33 responden (82,5%) tidak terkena Postpartum Blues. Bahwa terdapat hubungan antara kejadian postpartum blues dengan karakteristik reponden berdasarkan umur dan penghasilan dengan umur penghasilan
Hubungan Hipertensi Terhadap Kejadian Stroke
Authors: Puspitasari Puti Nadhirah
Published: December 2020

Latar belakang: Stroke didefinisikan sebagai gangguan suplai darah ke otak.Banyak faktor yang dapat memengaruhi kejadian stroke. Hipertensi merupakan faktor pencetus utama terjadinya kejadian stroke,baik stroke hemoragik ataupun iskemik.Tujuan : Mengetahui lebih lanjut mengenai hubungan hipertensi terhadap kejadian stroke. Metode : Metode yang digunakan adalah studi literatur yang diambil dari berbagai jurnal nasional dan internasional, metode ini berupaya meringkas kondisi pemahaman terkini mengenai suatu topik. Kesimpulan :Terdapat hubungan hipertensi terhadap kejadian stroke
Pengaruh Pemberian Sari Kurma Terhadap Peningkatan Kadar Hb pada Ibu Hamil
Authors: S Irmawati , Rosdiana Rosdiana
Published: December 2020

Anemia pada kehamilan dapat mengakibatkan dampak yang membahayaakan bagi ibu dan janin. Bahaya anemia terhadap kehamilan dapat terjadi abortus, persalinan prematuritas, mudah terjadi infeksi, ancaman dekompensasi Hemoglobin kurang dari enam, mola hidatidosa, hyperemesis gravidarum, perdarahan antepartum dan ketuban pecah. Tujuan penelitian adalah untuk mengetahi Pengaruh Pemberian Sari Kurma Terhadap Peningkatan Kadar Hemoglobin Pada Ibu Hamil Di Puskesmas Barrang Lompo Makassar, Metode penelitian yang digunakan adalah pre-eksperimental dengan rancangan one group pretest post test.  Penelitian ini menggunakan satu kelompok studi intervensi yaitu kelompok pemberikan sari kurma terhadap ibu hamil. Hasil penelitian dari lima belas responden menunjukkan bahwa ada peningkatan kadar hemoglobin pada ibu hamil setelah diberiankan sari kurma di Puskesmas Barrang Lompo, Kesimpulan dalam penelitian adalah ada pengaruh pemberian sari kurma terhadap peningkatan kadar hemoglobin pada ibu hamil artinya bahwa dengan mengkonsumsi sari kurma 3kali sehari dengan teratur selama kehamilan dapat meningkatkan kadar Hb pada ibu hamil.
Identifikasi Efek Protektif Berupa Antioksidan Terhadap Antioksidan
Authors: Aisyah Shalsabila Jasmira
Published: December 2020

Latar Belakang: Bawang putih adalah jenis tanaman sayuran umbi dari Allium sativum L. Bawang putih telah digunakan sebagai pengobatan herbal selama ribuan tahun karena senyawa aktif di dalamnya. Senyawa aktif sebagai antioksidan yang terdapat dalam kandungan bawang putih memegang peranan sangat penting untuk mencegah kerusakan sel dan organ dari proses oksidasi yang diakibatkan karena peningkatan radikal bebas oleh asap rokok. Tujuan: Mengidentifikasi efek protektif dari bawang putih berupa antioksidan terhadap radikal bebas. Metode: Menggunakan studi literature dari jurnal penelitian nasional maupun internasional dengan cara meringkas topik pembahasan dan membandingkan hasil yang disajikan daam artikel. Hasil: Bawang putih banyak diteliti sebagai antioksidan alami karena memiliki senyawa aktif organosulfur yang memiliki khasiat sebagai bahan terapeutik berupa antibakteri, antivirus, anti jamur, anti thrombotik, antibiotik, antikanker, antioksidan, immunomodulator, antiinflamasi, dan efek hipoglikemik. Zat organosulfur tersebut berupa flavonoid, adenosin, ahoene, dan alliin. Allyl tiosulfat, yang berasal dari alliin melalui proses alliinase bertanggung jawab dalam proses penurunan lipid, antikanker, dan antioksidan. Hasil dari berbagai macam penelitian, telah terbukti bahwa bawang putih local siung tunggal memiliki kandungan antioksidan yang lebih dibandingkan jenis lainnya. Penelitian terdahulu juga membuktikan bahwa dengan metode DPPH, aged garlic dengan pelarut etanol memiliki antioksidan yang lebih tinggi dibandingkan fresh garlic dan dengan pelarut air. Kesimpulan: Dari berbagai macam bawang putih yang ada, telah terbukti bahwa yang memiliki khasiat antioksidan lebih adalah bawang putih local siung tunggal dan aged garlic dengan pelarut ethanol dibandingkan fresh garlic serta senyawa aktif yang paling penting berupa allyl thiosulfat.
Pengaruh Ketebalan Lapisan Dentin Terhadap Kekuatan Tarik Pada Gigi Tiruan Cekat Keramik - Logam.
Authors: Handayani Riska
Published: December 2020

Gigi tiruan cekat keramik logam merupakan penggabungan antara bahan keramik dan logam yang bertujuan untuk mendapatkan sifat mekanik yang baik dari koping logam dan sifat estetika yang baik dari keramik. Koping logam dan lapisan keramik tersebut berikatan karena adanya ikatan kimia, dan ikatan mekanis. Tujuan dari penelitian untuk mengetahui pengaruh ketebalan lapisan dentin terhadap kekuatan tarik pada Gigi tiruan cekat keramik logam dengan ketebalan lapisan dentin 0,5 mm, 0,6 mm, 0,7 mm. Penelitian menggunakan eksperimental laboratorium secara in vitro, dengan rancangan penelitian post  test  only  control  group  design dengan  melakukan pengukuran dan observasi setelah perlakuan. Jumlah sampel seluruhnya terdapat 27 keramik logam, dikelompokkan menjadi 3 bagian iyaitu : 9 sampel dengan  ketebalan lapisan dentin 0,5 mm, 9 sampel dengan ketebalan lapisan dentin  0,6 mm dan 9 sampel dengan ketebalan lapisan  0,7 mm. Ada pengaruh ketebalan lapisan dentin terhadap kekuatan tarik pada Gigi tiruan cekat keramik logam dengan bahan dasar logam Co-Cr (p=0,000). Ketebalan lapisan dentin 0,7 mm yang menghasilkan kekuatan tarik paling optimal jika dibandingkan dengan ketebalan lapisan dentin 0,5 mm dan 0,6 mm terhadap Gigi tiruan cekat keramik logam dengan bahan dasar galom Co-Cr.
A performance musical das pessoas com deficiência visual
Authors: Escobar Tudissaki Shirlei
Published: December 2020

Este artigo teve como objetivo focalizar algumas das questões envolvidas na performance musical de pessoas com deficiência visual, a saber: os tipos de deficiência visual (baixa visão e cegueira; deficiência visual congênita e adquirida); a musicografia braille; os tipos de memória; a memória musical; e como se desenvolve a memória para o músico com deficiência visual. Para tanto, foi realizada uma pesquisa qualitativa/quantitativa, utilizando a entrevista semiestruturada e o questionário como técnicas para coleta de dados. A revisão de literatura, por sua vez, concentrou-se em textos relacionados à Música, Educação, Cognição Musical e Medicina.
STRATEGI POLITIK IKHWANUL MUSLIMIN TERHADAP KEBIJAKAN PEMERINTAH MESIR PASCA DIGULINGKANNYA MURSI
Authors: Ma'ruf Tholhah Ibnu
Published: December 2020

Penelitian ini akan membahas sebuah gerakan politik di Timur Tengah, tepatnya di negara Mesir yang bernama Ikhwanul Muslimin. Penelitian ini hanya dibatasi strategi politik Ikhwanul muslimin setelah lengsernya Presiden Mursi. Teknik pengumpulan data dalam penulisan karya ini menggunakan metode riset perpustakaan (library research), yaitu melalui pengumpulan data dari referensi buku, majalah, jurnal ilmiah dan media cetak lainnya. Strategi politik yang diusung Ikhwanul Muslimin sebagai Gerakan Islam Transnasional dalam merespon penetapan mereka sebagai gerakan Teroris oleh pemerintah mesir pasca digulingkannya Mursi adalah dengan melakukan reaksi baik tingkat domestik (Mesir) dan Internasional karena Ikhwanul Muslimin adalah sebuah Gerakan Transnasional.
TINJAUAN BUKU: MENYOAL KEDAULATAN INDONESIA DALAM FLIGHT INFORMATION REGION (FIR) INDONESIA-SINGAPURA
Authors: Ismail Achmad
Published: December 2020

Judul : Langit Indonesia Milik siapa? Makna Strategis Wilayah Pengendalian Udara (FIR) Indonesia-Singapura

Tahun Terbit : 2017

Penerbit : Elex Media Komputindo

Penulis : Yanyan M. Yani, Ian Montratama & Ikrardhi Putera

Jumlah Halaman : 176 Halaman

ISBN : 978-602-04-0054-9
INCREASING OF THE DURABILITY OF DETAILS WORKING UNDER REPEATABLE- LOADS
Authors: Matviychuk Viktor , Gaidamak Oleg
Published: December 2020

The article develops processes of increase the durability of parts operating under repeated loads, by justifying the parameters of surface plastic deformation (SPD) and cold gas-dynamic coating. The influence on the depth of the reinforced surface layer, the nature of the distribution of the stress-strain state of the material and residual compressive stresses, as well as the value of the used plasticity of the metal, the parameters of the SPD process. The hypothesis is substantiated that the main factor in the formation of residual compressive stresses during SPD is the decrease in metal density, which is associated with the use of the plasticity resource. The model of definition of the used resource of plasticity of metals at SPD is developed, that allows to provide qualitative characteristics of a surface layer of details. Methods for shifting the layer with maximum hardening and residual compressive stresses to the surface of the part by using a deformable tool of smaller dimensions in subsequent passes and gas-dynamic coating before SPD.

The vast majority of traditional gas-thermal coating methods occur at significant temperature effects on the surface of the part, which is unacceptable for the surface treated by SPD methods. Cold gas-dynamic spraying provides an allowable temperature regime for the creation of special auxiliary coatings while maintaining the properties of the surface treated by SPD methods.
The technology of gas-dynamic coating includes heating the compressed gas (air), feeding it into the nozzle and forming a supersonic air stream in this nozzle, introducing a powder material into this stream, accelerating this material in the nozzle by a supersonic air flow and directing it to the surface of the workpiece. As a result, a special auxiliary coating is formed on the surface of the product, which provides optimal parameters of the SPD process.
INCREASING THE EFFICIENCY OF SURFACE STRENGTHENING OF METAL PRODUCTS BY COMBINED THERMODEFORMATION PROCESSING
Authors: Danyleiko Oleksandr , Dzhemelinskyi Vitaliy , Lesyk Dmytro , Bernatskyi Artemii
Published: December 2020

The article discusses the prospects of using combined thermal deformation surface processing to improve the performance properties of metal products. There is a new method of thermal deformation surface hardening (shot peening (SP) followed by laser heat treatment (LHT)) for tools and crown housings operating under difficult conditions proposed. For carrying out experimental studies, flat samples of 30KhGSA steel and steel 45 were selected. Preliminary hardening and finishing with static or dynamic methods of surface plastic deformation were carried out on a modernized installation based on a DYNAMITE 2800 numerical control machine, and SP was implemented on industrial equipment. Laser surface hardening of the samples was carried out in single passes with a sample moving speed of 300...500 mm/min with a laser beam diameter of 7.3 mm and a laser power of 1 kW using the ROFIN-SINAR DY 044 technological unit. The optimal regimes of surface hardening are determined under the deformation action of a gas-dynamic flow with solid particles and thermal action by a laser beam to obtain maximum values ​​of hardening depth and hardness. In particular, with SP, the gas-feed stream feed pressure is 0.5 MPa, the processing time is 1 min, regardless of the type of material. The optimal laser beam power is 1 kW at a sample travel speed of 300 mm/min. There are the results of experimental studies of the change in the hardening depth as a function of time and pressure after SP, the speed of movement of the treated sample from carbon steel 45 and medium alloyed steel 30KhGSA after LHT and combined SP+LHT, and also the distribution of microhardness over the depth of the hardened layer presented. It is revealed that the combined SP+LHT of 30 KhGSA steel at optimal modes forms 1.5 times (1.3 mm) greater depth of the strengthened surface layer in comparison with LHT, while providing the surface layer hardness of ~5400 MPa.
PHYSICO-MATHEMATICAL MODEL OF THE HYDRO-INJECTOR’S OPERATION OF THE DAIRY PROCESSING PLANTS’ WASHING SYSTEM
Authors: Babyn Ihor
Published: December 2020

The article discusses the prospects of using combined thermal deformation surface processing to improve the performance properties of metal products. There is a new method of thermal deformation surface hardening (shot peening (SP) followed by laser heat treatment (LHT)) for tools and crown housings operating under difficult conditions proposed. For carrying out experimental studies, flat samples of 30KhGSA steel and steel 45 were selected. Preliminary hardening and finishing with static or dynamic methods of surface plastic deformation were carried out on a modernized installation based on a DYNAMITE 2800 numerical control machine, and SP was implemented on industrial equipment. Laser surface hardening of the samples was carried out in single passes with a sample moving speed of 300...500 mm/min with a laser beam diameter of 7.3 mm and a laser power of 1 kW using the ROFIN-SINAR DY 044 technological unit. The optimal regimes of surface hardening are determined under the deformation action of a gas-dynamic flow with solid particles and thermal action by a laser beam to obtain maximum values ​​of hardening depth and hardness. In particular, with SP, the gas-feed stream feed pressure is 0.5 MPa, the processing time is 1 min, regardless of the type of material. The optimal laser beam power is 1 kW at a sample travel speed of 300 mm/min. There are the results of experimental studies of the change in the hardening depth as a function of time and pressure after SP, the speed of movement of the treated sample from carbon steel 45 and medium alloyed steel 30KhGSA after LHT and combined SP+LHT, and also the distribution of microhardness over the depth of the hardened layer presented. It is revealed that the combined SP+LHT of 30 KhGSA steel at optimal modes forms 1.5 times (1.3 mm) greater depth of the strengthened surface layer in comparison with LHT, while providing the surface layer hardness of ~5400 MPa.
RESEARCH OF VIBRATION MACHINES DYNAMICS FOR PRODUCT SURFACES PROCESSING BY MATHEMATICAL MODELING
Authors: Topilnytskyy Volodymyr , Kusyi Yaroslav , Rebot Dariya
Published: December 2020

The article describes the methodology for the study of the dynamics of vibrating machines for surface processing of products by mathematical modeling, which is presented in four main stages. The first stage: analysis of classes of vibrating machines for surface treatment of products, choice of basic for solving the technological problem, project of a unified calculation scheme of the machine. The second stage: development of a nonlinear mathematical model for describing the dynamics of the vibration machine working body and its filling, development of elements of automated calculations of the machine. The third stage: the study of the influence of the parameters of the vibrating machine, product sets and tools (with their various combinations) on the factors of the intensity of products surface processing. The fourth stage: recommendations for choosing vibrating machine parameters and machining bodies that will maximize the processing performance of products with the selected intensity criterion.
A mathematical model for describing the motion of a vibrating machine for surface treatment of articles by a set of unrelated bodies of small size is created. It has two unbalance units that generate oscillations of its working body and a spring suspension-mounting of the working chamber (container). The model is parametric and nonlinear, incorporating key dynamic, kinematic and geometric parameters of the vibrating machine in symbolic format. It is constructed by: descriptions of the plane-parallel movement of the mechanical system, the rotational motion of the material point and the body; second-order Lagrange equation; asymptotic (approximate) methods of nonlinear mechanics. With the help of the model it is possible: to describe the oscillatory movement of the working chamber (container) of the vibrating machine; to study the influence of the machine parameters on the efficiency of performance of the set technological task, the conditions of occurrence of non-stationary modes of operation of the vibrating machine and the ways of their regulation.
DYNAMICS OF DEVELOPMENT AND EVALUATION OF AGILITY IN SCHOOL EDUCATION (1st-12th GRADE)
Authors: Tarnichkova Milena , Petrova Marina
Published: December 2020

Physical activity is an important criterion for a healthy lifestyle and a prerequisite for improving the motor abilities of adolescents. The aim of this study is to establish the level of development of physical quality agility in all stages of school education. In order to fulfill the set aim of the research, we used sports­pedagogical testing. The research was carried out with 232 pupils from 1st to 12th grade. We used variation analysis and comparative analysis with t-criterion of Student for independent samples to process the study results. Following the dynamics of the development of the studied indicator between the different classes, we report a positive increase six times, and a decrease in the result - three times (from 2nd to 3rd grade; from 7th to 8th grade and from 10th to 11th grade). Between grades 5th – 6th and 8th – 9th there was no increase in the results. The average number of points reported for each class ranged between 9 and 13 points, which according to the evaluation table means a “GOOD” assessment of agility development. Our study shows that the dynamics of the mean level of the researched indicator in the age aspect changes regressively, with the values decreasing from 1st to 12th grade. Comparing the changes in the mean values of pupils divided by class and gender, we established that, overall, boys are faster than girls when performing the test.
MODELING OF THE TRAINING PREPARATION OF HIGHLY QUALIFIED FEMALE HOCKEY PLAYERS
Authors: Shishkov Igor
Published: December 2020

The article is devoted to the study of effectiveness of building training and competitive loads of women’s national team of the Republic of Belarus for the European Indoor Hockey Champion ship (Indoor Hockey). The study was conducted at a separate, three-month stage of the annual training cycle. The Purpose of the study: To find optimal ratio between training and competitive loads using block training system for highly qualified hockey players. To achieve the goal, the following Tasks were set: 1. To determine the structure of training of Belarus national hockey players in clubs and during the training camps of the national team before the European Championship; 2. To evaluate training and competitive process as two separate areas of training for highly qualified hockey players; 3. To identify necessary volume and evaluate effectiveness of the use of non­specifi c loads of anaerobic orientation in shock microcycles during training process of hockey players and final result. Research hypothesis: it was assumed that control and test games, as well as non­specifi c loads of anaerobic orientation in shock microcycles, may have a positive effect on the efficiency of using block system for preparing highly qualified hockey players for a short-term tournament. An analysis of the training structure of the women’s national team of the Republic of Belarus is presented from the perspective of the modern block system of periodization. Thus, it can be stated that the polycyclic principle of building the training process in Indoor hockey game sport is approved today. The obtained data on the structure of training of hockey players can be used as model characteristics.