bluuebunny/crossref_metadata_2025 huggingface dataset:
Spontaneous Cleavages of a Heterologous Protein, the CenA Endoglucanase of Cellulomonas fimi, in Escherichia coli
Authors: Lai Cheuk Yin , Ng Ka Lun , Wang Hao , Lam Chui Chi , Wong Wan Keung Raymond
Published: June 2021

CenA is an endoglucanase secreted by the Gram-positive cellulolytic bacterium, Cellulomonas fimi, to the environment as a glycosylated protein. The role of glycosylation in CenA is unclear. However, it seems not crucial for functional activity and secretion since the unglycosylated counterpart, recombinant CenA (rCenA), is both bioactive and secretable in Escherichia coli. Using a systematic screening approach, we have demonstrated that rCenA is subjected to spontaneous cleavages (SC) in both the cytoplasm and culture medium of E. coli, under the influence of different environmental factors. The cleavages were found to occur in both the cellulose-binding (CellBD) and catalytic domains, with a notably higher occurring rate detected in the former than the latter. In CellBD, the cleavages were shown to occur close to potential N-linked glycosylation sites, suggesting that these sites might serve as ‘attributive tags’ for differentiating rCenA from endogenous proteins and the points of initiation of SC. It is hypothesized that glycosylation plays a crucial role in protecting CenA from SC when interacting with cellulose in the environment. Subsequent to hydrolysis, SC would ensure the dissociation of CenA from the enzyme-substrate complex. Thus, our findings may help elucidate the mechanisms of protein turnover and enzymatic cellulolysis.
“Don’t praise the day before the sunset”: Paremiology in the study of depressiveness
Authors: Wołońciej Mariusz , Wilczewski Michał , Kreitler Shulamith
Published: June 2021

Psychology and psychiatry are in a constant search for an adequate model of affective disorders. Psychology has classified depression as a mood disorder, but a growing literature links mental disorders with socioculturally relevant ways in which people experience and express distress. With this study, we link depression with proverbs as omnipresent narrative structures and mini-theories that help people interpret reality and categorize personal experience. Proverbs are omnipresent narrative structures that describe, explain, and prescribe human behavior. Hence, we offer a paremiological approach to better understand the minds of the depressed. Our tenet is that proverbs may also reflect people’s mental states and attitudes by conveying different levels of optimism versus pessimism. We evidence empirically that proverbs convey optimistic and pessimistic attitudes and, thus, have the capacity to capture peoples’ mental states. Moreover, we show that this capacity is limited for people with high depressiveness. Finally, we discuss how proverbial thinking links collective experience and wisdom imprinted in proverbs with an individual’s mental states, which has important research and practical implications.
Goal attainment scaling—community-based: A method to incorporate personalized outcomes into intervention research with youth and adults on the autism spectrum
Authors: Lee Chung Eun , Shogren Karrie A , Segal Jordan , Pezzimenti Florencia , Aleman-Tovar Janeth , Taylor Julie Lounds
Published: June 2021

Given the wide heterogeneity in the autism population, one challenge for intervention studies is to identify outcome measures that have similar meaning across individuals. This is particularly pronounced in intervention studies of adults with autism spectrum disorder, where outcomes such as employment, independence, or community living are common targets. However, these outcomes can be more challenging to obtain for those who have greater support needs, for example, and therefore may be more or less salient depending on the sample under study. Goal attainment scaling can help address this issue as it allows individuals to identify personally meaningful goals and track progress toward these goals. While goal attainment scaling is gaining popularity in the autism field as an outcome measure, most intervention studies that use goal attainment scaling have been situated in clinical or school settings. Generating reliable and scalable goals outside of these settings can be challenging. In this article, we describe the promise of goal attainment scaling for tailoring individualized outcomes among youth and adults with autism spectrum disorder and discuss the challenges of current goal attainment scaling methods in community-based intervention research. We then describe a new goal attainment scaling approach that is rigorous, practical, and can be used across research settings to measure individualized outcomes.

Lay abstract

Among people with autism—all who have the same diagnosis—there are major differences on a nearly limitless number of areas, such as language, daily living skills, intellectual ability, sensory difficulties, and physical and mental health diagnoses. Despite these many differences, the targeted outcomes of intervention studies are often measured the same way across autistic adults, including outcomes such as getting a job, achieving greater independence, or getting more services. People have different goals and abilities, and it is important to have a way for intervention studies to measure outcomes in a way that is more personal to each individual. To address this issue, we developed a new approach—called “Goal Attainment Scaling—Community-based” or GAS-CB—to measure individualized outcomes across different research settings. In this article, we describe the need for individualized outcomes in autism intervention research and current approaches to gathering these outcomes, with our discussion focused on a method called goal attainment scaling. We then describe reasons why current goal attainment scaling approaches might not be useful in intervention research that takes place in the community. Finally, we discuss a new goal attainment scaling approach (GAS-CB) that can be flexibly used for research participants with very different characteristics.
Coronavirus conspiracy beliefs and distrust of science predict risky public health behaviours through optimistically biased risk perceptions in Ukraine, Turkey, and Germany
Authors: Chayinska Maria , Uluğ Özden Melis , Ayanian Arin H. , Gratzel Johanna Claudia , Brik Tymofii , Kende Anna , McGarty Craig
Published: June 2021

The present paper examines the extent to which conspiracy beliefs about the COVID-19 outbreak and distrust of epidemiological science are likely to predict optimistically biased risk perceptions at the individual and group levels. We explored the factor structure of coronavirus conspiracy beliefs and their associations with trust in science in predicting risk perceptions using survey data collected in Ukraine ( N = 390), Turkey ( N = 290), and Germany ( N = 408). We further expected conspiracy beliefs and distrust of science to predict people’s willingness to attend public gatherings versus maintaining preventive physical distancing through optimistically biased risk perceptions. Metric noninvariance for key constructs across the samples was observed so the samples were analysed separately. In Ukraine, a two-factor structure of conspiracy beliefs was found wherein COVID-19 bioweapon (but not COVID-19 profit) beliefs were negatively associated with public gathering through optimistically biased individual risk perceptions. In Turkey and Germany, conspiracy beliefs showed a single-factor solution that was negatively associated with preventive distancing and positively related to public gathering through optimistically biased public risk metaperceptions. The hypothesis about the direct and indirect effects of trust in science on risky health behaviour was partially confirmed in all three samples. The observed discrepancies in our findings are discussed.
Agenda-setting in social TV: How and when user comments influence perceived issue importance
Authors: Chung Myojung , Seo Young Nam , Jung Younbo , Lee Doohwang
Published: June 2021

As a combination of television viewing and social media use, social TV epitomizes the intersection of mass communication and interpersonal communication. However, it remains unknown how such a novel format of media experience influences the agenda-setting effects. A lab experiment ( N = 120) examined (a) how user-to-user interactions in social TV (i.e. real-time comments from virtual co-viewers) affect the agenda-setting process and (b) how such effect is moderated by different interface types (e.g. all-in-one screen vs a second screen). Results suggest that participants who watched a news clip that featured many (vs few) comments from virtual co-viewers perceived the issue to be more important, but such effect was at work only when user comments were viewed on the second screen. In addition, exposure to many (vs few) comments decreased participants’ satisfaction with social TV and their intention to use social TV in the future.
Modelling liquid film in modern GDI engines and the impact on particulate matter emissions – Part 1
Authors: Biagiotti Federico , Bonatesta Fabrizio , Tajdaran Sadjad , Sciortino Davide Domenico , Verma Sunny , Hopkins Edward , Morrey Denise , Yang Changho , Spencer Adrian , Jiang Changzhao , Haigh Robert
Published: June 2021

This paper presents the details of a Computational Fluid Dynamics methodology to accurately model the process of mixture preparation in modern Gasoline Direct Injection engines, with particular emphasis on liquid film as one of the main causes of Particulate Matter formation. The proposed modelling protocol, centred on the Bai-Onera approach of droplets-wall interaction and on multi-component surrogate fuel blend models, is validated against relevant published data and then applied to a modern small-capacity GDI engine, featuring centrally-mounted spray-guided injection system. The work covers a range of part-load, stoichiometric and theoretically-homogeneous operating conditions, for which experimental engine data and engine-out Particle Number measurements were available. The results, based on the parametric variation of start of injection timing and injection pressure, demonstrate how both fuel mal-distribution and liquid film retained at spark timing, may contribute to PN emissions, whilst their relative importance vary depending on operating conditions and engine control strategy. Control of PN emissions and compliance with future, more stringent regulations remain large challenges for the engine industry. Renewed and disruptive approaches, which also consider the sustainability of the sector, appear to be essential. This work, developed using Siemens Simcenter CFD software as part of the Ford-led APC6 DYNAMO project, aims to contribute to the development of a reliable and cost-effective digital toolset, which supports engine development and diagnostics through a more fundamental assessment of engine operation and emissions formation.
The governance of learning: Carrots, sticks, and stones in acquisition capability development
Authors: Schijven Mario , Kolev Kalin D , Haleblian Jerayr (John)
Published: June 2021

A growing literature suggests that deliberate, cognitive effort is necessary for learning to occur in the context of complex strategic activities. However, given increasing pressure for short-term results, it remains unclear what motivates management to actually invest such effort in learning, which benefits performance primarily in the longer term. To help fill this gap in our understanding of the motivational mechanisms behind organizational learning, we theorize whether and how corporate governance mechanisms push management toward more effective learning from its firm’s acquisition experience. Using data on U.S. firms’ acquisitions from 1996 through 2012, we find considerable support for our arguments.
COVID-19 Efforts at the Institute of Image Guided Surgery (IHU-Strasbourg): 2020
Authors: Swanstrom Lee , Perretta Silvana , Pizzicannella Margherita , Rodriguez-Luna Maria Rita , Verde Juan , Garcia Alain , Gallix Benoit
Published: June 2021

We submit a summary of some of the activities of the IHU-Strasbourg during the initial period of the COVID-19 pandemic. These were presented as part of the coronnavation effort coordinated by Dr Adrian Park. Three initiatives are presented as follows: Protect-Est App, healthcare worker stress, and converted diving mask for ventilation. Two of the 3 projects are still ongoing, and one (Predoict-Est) has been adopted nationally.
The use of the Amplatzer Vascular Plug in the prevention of endoleaks during abdominal endovascular aneurysm repair: A systematic literature review on current applications
Authors: Bracale Umberto M , Petrone Anna , Provenzano Michele , Ielapi Nicola , Ferrante Liborio , Turchino Davide , del Guercio Luca , Pakeliani David , Andreucci Michele , Serra Raffaele
Published: June 2021

Objectives

The Amplatzer Vascular Plug (AVP) is a vascular occlusion device designed to provide optimal embolization in several fields of the endovascular surgery. A full literature review was conducted to analyze AVPs in comparison with coils for the prevention of endoleaks during endovascular abdominal aortic aneurysm repair.

Methods

A systematic review was designed under PRISMA statement guidelines for systematic reviews and meta-analyses. The results were updated with a subsequent electronic search using Medline and Scopus databases up to December 2019.

Results

Eighteen articles making this comparison were found. In 79.7% of the cases, the target vessel was the internal iliac artery; in 1.6%, the common iliac artery; and in 16.7%, the inferior mesenteric artery. Risk of complications (buttock claudication, groin hematoma, endoleaks, and erectile dysfunction) after AVP was low. A cost comparison revealed that the mean cost for coils was around US$2262, while the average cost for the AVP was US$310.

Conclusions

The AVP is an effective and safe device for occluding peripheral vessels, proved to have lower complications rates. Compared with coil embolization, the AVP technique is potentially associated with lower procedural costs.
Framing, Context, and the Misperception of Black–White Wealth Inequality
Authors: Kraus Michael W. , Hudson Sa-kiera T. J. , Richeson Jennifer A.
Published: June 2021

In one large-scale experiment using U.S. respondents on Mechanical Turk ( N = 2,899), we studied how subtle differences in framing and context impacted estimates of the Black–White wealth gap. Across our 10 different experimental manipulations of framing and context, respondents consistently overestimated Black family wealth relative to White wealth. There was also substantial variation in the magnitude of these wealth estimates, which ranged from a low of 35 to a high of over 60 percentage points across the conditions. Overestimates were largest when respondents were asked about the Black–White wealth gap at both past and present time points and closest to accuracy when respondents used images as pictorial comparisons for White and Black wealth. Overall, while framing and context certainly affect the magnitude of this misperception, the tendency to overestimate racial wealth equality is extremely robust.
COVID-19 and digitized education: Analysis of online learning in Nigerian higher education
Authors: Egielewa Peter , Idogho Philipa O , Iyalomhe Felix O , Cirella Giuseppe T
Published: June 2021

This study aims at investigating student perception of Nigerian institutions of higher learning using the new digital culture induced by the COVID-19 pandemic, namely, online learning (i.e. e-learning), that has become commonplace globally and specifically in Nigeria. The study used quantitative survey methods and a sample size of 1134 Nigerian students of the three types of higher institutions in Nigeria: universities, polytechnics, and colleges of higher education based on student state residential location. The respondents completed a questionnaire via Google Forms in June and July 2020. The study found that students are not satisfied with virtual learning embarked upon by many higher institutions throughout the country during the COVID-19 lockdown and would not want the online learning to continue after the pandemic due to poor internet infrastructure and lack of electricity. The study concluded that students of higher education in Nigeria have a low acceptance of online learning technology, preferring instead the traditional classroom setting, and thus putting them in the “Laggards adopter categorization” of the diffusion innovation theory, i.e., the group that is highly conservative and extremely slow to accept new technological innovations. The study recommends that universities should engage students more interactively not only through texts but also video (e.g. camera demonstrations), increase their online learning during the pandemic so as not to lag academically, and spend more time on online learning to get the best possible level of instruction until traditional learning resumes. Also, it is recommended that administrators of Nigerian higher institutions should return to a traditional learning format as soon as the pandemic is over as well as an overhaul and restructuring of the internet and power grid nationwide.
Achenbach’s hand and digital paroxysmal haematomas: a possible association with joint hypermobility syndrome in two sibling cases
Authors: Anthony Clive Chate Robert
Published: June 2021

A pair of middle-aged sisters is presented who experienced episodes of spontaneous, relatively atraumatic, acute onset, painful sub-cutaneous bleeding into the digits of their hands over a number of preceding years. A literature search revealed they had Achenbach’s syndrome, which is a benign and self-limiting condition that resolves completely within 2–4 days. However, a hitherto unreported association between Achenbach’s syndrome and joint hypermobility with its abnormal collagen is made, along with a tentative causality hypothesis that perhaps in the presence of atypical connective tissue, the architecture and integrity of the peripheral capillary bed of the hand could be adversely affected and therefore predispose towards paroxysmal palm and/or finger bleeds.
Retrospective Analysis of Tacrolimus Intrapatient Variability as a Measure of Medication Adherence
Authors: Herblum Jordana , Dacouris Niki , Huang Michael , Zaltzman Jeffrey , Prasad G. V. Ramesh , Nash Michelle , Chen Lucy
Published: June 2021

Background:

Increased intrapatient variability (IPV) in tacrolimus levels is associated with graft rejection, de novo donor-specific antibodies, and graft loss. Medication nonadherence may be a significant contributor to high IPV.

Objective:

The objective of this study is to determine the utility of tacrolimus IPV in detecting nonadherence by examining the relationship between self-reported adherence and tacrolimus coefficient of variability (COV), a measure of IPV.

Design:

Retrospective cohort study.

Setting:

St. Michael’s Hospital, Toronto, Ontario.

Patients:

All patients who were at least 1-year post-kidney transplant as of March 31, 2019, prescribed tacrolimus as an immunosuppressant and had a self-reported adherence status. Patients were excluded from the primary analysis of examining the correlation between COV and self-reported adherence if they lacked a calculatable COV.

Measurements:

Self-reported adherence, COV, demographic data, transplant, and medication history.

Methods:

A modified Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS) administered by healthcare professionals to assess self-reported adherence was used. The COV of tacrolimus trough levels was calculated and its correlation to BAASIS response was noted. The median COV was used as a cutoff to examine the characteristics of patients deemed “high COV” and “low COV.”

Results:

A total of 591 patients fit the initial criteria; however, only 525 had a recent calculatable COV. Overall, 92.38% of the population were adherent by self-report. Primary analysis identified a COV of 25.2% and 29.6% in self-reported adherent and nonadherent patients, respectively, though the result was not significant ( P = .2). Secondary analyses showed a significant correlation between younger age at transplant and at the time of adherence self-reporting with nonadherence ( P = .01). In addition, there was a strong correlation between those nonadherent with routine post-transplant blood work and younger age ( P < .01).

Limitations:

The limitations included modified nonvalidated BAASIS questionnaire, social desirability bias, BAASIS only administered in English, and patients with graft failure not active in clinic not being captured.

Conclusions:

The COV should not be used as the sole method for determining medication adherence. However, COV may have some utility in capturing individuals who are not adherent to their blood work or patients who are having a poor response to tacrolimus and should be switched to another medication.
Effectiveness of massage therapy on fatigue and pain in patients with multiple sclerosis: A systematic review and meta-analysis
Authors: Salarvand Shahin , Heidari Mohammad Eghbal , Farahi Kazem , Teymuri Erfan , Almasian Mohammad , Bitaraf Saeid
Published: June 2021

Background

Fatigue and pain are prevalent symptoms of multiple sclerosis (MS) and frequent complaint in MS patients, which reduce their quality of life. This study aimed to assess the effect of massage therapy on pain and fatigue in MS Patients.

Method

The original and Persian databases were searched included PubMed, web of science, embase, ovid, scopus, and the Cochrane Library, SID, and Iranedex from inception to November 2020. Studies that reported the effect of massage on fatigue and pain were included. Two investigators extracted all relevant data, independently. For deriving analysis, mean difference (MD) and standardized mean difference (SMD) were used.

Result

Ten studies were eligible acoording criteria. The effect of massage on fatigue showed significant improvement (−1.62; 95% CL −2.40, −0.83; p < .00001), also results of the systematic review showed a significant reduction in pain severity.

Conclusion

Massage as a complementary and non-pharmacological therapy might have been associated with alleviating fatigue and pain in M.S. patients. Based on the current study, massage intervention for MS patients could have possible clinical value for palliating pain and fatigue and improving quality of life; however, this matter needs further and more significant trial studies.
Self-Assessment of Teachers’ Communication Style and Its Impact on Their Communication Effectiveness: A Study of Indian Higher Educational Institutions
Authors: Dhillon Navdeep , Kaur Gurvinder
Published: June 2021

The excellence of educational institutions can be developed and improved by the teachers’ consistent and effective communication in classrooms. This study embarks to investigate the effect of teachers’ communication style (CS) on their communication effectiveness (CE), based on self-assessment, during classroom teaching. The results indicate that CS has significant influence on CE, with “Expressiveness” and “Preciseness” emerging as best styles of communication, whereas “Verbal Aggressiveness” has negative impact on faculties’ CE. It also investigates the differences in CE of the faculty based on their gender and subject specialization. Findings indicate gender differences on the basis of two CE variables—“Listening” and “Ability to get the Message Across.” But there is no difference in instructors’ CE when compared on basis of subject specialization. The findings of the study have implications for the faculty members to enhance their CE, by understanding their CS, which will further have an impact on students’ satisfaction and learning.
Investigating Pre-Service Early Childhood Teachers’ cPCK and pPCK on the Knowledge Used in Scientific Process Through CoRe
Authors: Buldu Elif , Buldu Metehan
Published: June 2021

The study aimed to investigate pre-service early childhood teachers’ (PSTs) collective pedagogical content knowledge (cPCK) and personal pedagogical content knowledge (pPCK) on the knowledge used in scientific process (SP) through the content representation (CoRe) design, interview, and knowledge used in scientific process (KSP) forms. The data were collected from 36 sophomore PSTs’ with a case study design. At the beginning of the data collection process, the PSTs’ prior knowledge used in SP was determined individually through a pre-interview and the KSP form. At the conclusion of the 13-week science-focused course, post-interviews, the KSP form, and the CoRe form were applied again. The CoRe forms were filled collectively based on their science activities, which were designed at the end of the science course. The PCK developed by Magnusson et al. was used for data analysis and to decide on the main themes of the data. The study’s findings revealed that the PSTs initially had some misconceptions relating to knowledge of SP. While the participants were confused about the knowledge used in SP and made incorrect definitions prior to the science-focused course, nearly all of the PSTs’ conception were changed on all of the concepts used in SP and reflected the most confused skills (especially observing and measuring) to their teaching plans after the course. Therefore, their pPCK and cPCK development were supported by both the science-focused course and collaborative CoRe design. The findings of the study have important implications for government policies and teacher training programs.
Repelolicer: A Reality or Snake Oil
Authors: Hussain Umer , Yu Bo
Published: June 2021

While head lice continue to be a worldwide health issue, there remains a dearth of scholarship detailing how various organizations are developing different products to deal with this problem. In this case study, the authors ponder upon a novel entrepreneurial idea developed by the students to tackle the lice issue in Pakistan. A team of students developed Repelolicer, an ultrasonic wave-emitting hairband to stop lice infestation among younger-aged girls. The Repelolicer team developed various strategies to target the Pakistani market. However, due to inadequate knowledge of the external market, the entrepreneurial idea failed to succeed.

Research Objective:

This case study aimed to explore challenges faced by an entrepreneurial venture using the first-mover strategy while penetrating the lower strata market via a product, which had a stigmatized effect.

Link to Theory:

In the extant scholarship, first-movers are considered to have strategic advantages against new rivals. In this study, we explore the disadvantages of first-mover in a complex Pakistani market situation through the lens of the resource-based view (RBV) and industrial organization (IO) perspective.

Phenomenon Studied:

This case study focuses on exploring the reasons behind the failure of tech-based first-movers (i.e., Repelolicer) in the Pakistani market scenario. The study also elucidates various external factors—a new venture should explore before launching a product in a Pakistani market situation.

Case Context:

The context in this case study is the lice problem among younger-aged girls in Pakistan’s lower strata market.

Findings:

The study participants unveiled that despite Repelolicer having competitive advantages because of internal factors, the Repelolicer team could not fully understand invisible forces in the external market. This lack of understanding led to their product failure. The Repelolicer team was also unable to comprehend how the product design might have further escalated the stigma attached to lice in society. Lastly, their pricing and promotion strategy was incompatible with the complex market situation.

Discussions:

This study adds to the limited knowledge about first-movers’ disadvantages in developing countries, such as Pakistan. The study results revealed that being a first-mover, even with all the adequate resources, is not always advantageous. The new ventures can especially face disastrous consequences for being the first-mover due to their lack of experience and knowledge of the local market. The study results also showed that new ventures should take the IO perspective with the RBV approach to succeed in a complicated market situation. The theoretical and practical implications of the case study have been outlined.
Preventing Tommy John Surgery: The Identification of Trends in Pitch Selection, Velocity, and Spin Rate Before Ulnar Collateral Ligament Reconstruction in Major League Baseball Pitchers
Authors: Mayo Benjamin C. , Miller Adam , Patetta Michael J. , Schwarzman Garrett R. , Chen Jeffrey W. , Haden Marshall , Secretov Erwin , Hutchinson Mark R.
Published: June 2021

Background:

Ulnar collateral ligament (UCL) reconstruction is a common surgery among Major League Baseball (MLB) pitchers that results in a significant number of missed games. Little has been reported regarding game-by-game trends that can identify those on the verge of becoming injured.

Purpose:

To determine if there is a patterned change in MLB pitchers’ pitch selection, velocity, or spin rate in games leading up to Tommy John surgery that may predict subsequent UCL surgery.

Study Design:

Case series; Level of evidence, 4.

Methods:

A retrospective review of MLB pitchers who underwent primary UCL reconstruction between 2009 and 2019 was performed. Pitch characteristics were evaluated on a game-by-game basis for the 15 games leading up to surgery. A Mann-Kendall trend test was used to identify trends in pitch selection, velocity, and spin rate for multiple pitch types. A Kendall τb correlation coefficient was identified, with values closer to 1 or –1 signifying a stronger monotonic trend.

Results:

A total of 223 MLB pitchers underwent UCL reconstruction in the time period. In the 15 games leading up to surgery, decreases in pitch velocity for 4-seam fastballs (τb = –0.657; P < .001), 2-seam fastballs (τb = –0.429; P = .029), and sliders (τb = –0.524; P = .008) were significantly associated with game number closer to injury. There was a significant positive association in the spin rate for cutters (τb = 0.410; P = .038) and a significant negative association in spin rate for 4-seam fastballs over the course of these 15 games (τb = –0.581; P = .003). In addition, there was a significant positive association in the percentage of curveballs thrown (τb = 0.486; P = .013).

Conclusion:

The study results suggest that there is a patterned change in certain pitch statistics in MLB pitchers in the games leading up to Tommy John surgery. Although the absolute change from game to game may be small, it may be possible for these trends to be monitored before a player becomes injured, thus reducing the significant burden Tommy John surgery places on these athletes.
When Your Boss Says, “You Need to Sound More Professional”: Writing Style and Writer Attributions
Authors: Campbell Kim Sydow , Naidoo Jefrey S. , Smith Jordan
Published: June 2021

One line of prior research has focused on the effect of style on readers’ ability to comprehend or willingness to engage with a message. A separate line has illuminated the effect of errors on the impressions readers form about writers, identifying potentially serious consequences (e.g., the willingness to accept the writer as a coworker or to fund the writer’s business pitch). To date, few studies have investigated the effect of style on the impressions readers form of business writers. In this paper, we report a study of the relationship between business writer attributions and word- or sentence-level style features often emphasized by advocates of plain style. Using data from 614 respondents, we found statistically significant evidence that business writers conveyed (a) confidence by avoiding non-requisite words, jargon, and nominals and by using standard connotations and grammar, and (b) professionalism by avoiding non-requisite words and hedges and by using standard homonyms.
Framing Sustainable Finance: A Critical Analysis of Op-eds in the Financial Times
Authors: Strauß Nadine
Published: June 2021

Being at the forefront in the public discussion about sustainable finance (SF) has become a competitive advantage for financial corporations. This study investigates op-eds by representatives of major global investment banks and asset managers (Black Rock, Goldman Sachs, HSBC, Morgan Stanley, UBS) published between 2018 and 2019 in the Financial Times regarding SF. Using an in-depth textual analysis approach, five overarching frames emerged: (1) climate crisis consensus and the urgency to act, (2) sustainable finance as powerful leverage, (3) sustainability in the name of profit and capital growth, (4) need for transparency, quantification, and datafication, and (5) shifting responsibilities. The results imply that SF is used as a public relations tool to promote new, lucrative financial activities that fit within the prevailing neoliberal market model. Rather than providing alternatives to the prevailing financial markets, the investment industry shifts responsibilities to the government, businesses and individuals to fight climate change.
Moderating Roles of Resilience and Social Support on Psychiatric and Practice Outcomes in Nurses Working During the COVID-19 Pandemic
Authors: Schierberl Scherr Anna E. , Ayotte Brian J. , Kellogg Marni B.
Published: June 2021

Introduction

Staff and equipment shortages and an easily transmissible virus make working in the COVID-19 pandemic demanding physically and psychologically. Nurses on the frontlines are particularly vulnerable to the adversity of working under these conditions, particularly with regard to mental health. Thus, understanding risk and protective factors for this vulnerable and essential group is critical for identifying potential targets of interventions. We had two aims for the current study: (a) to examine work functioning and symptoms of depression, anxiety, and posttraumatic stress (PTSD) among nurses who did and did not care for patients with COVID-19; and (b) to determine if resilience and social support moderate these relationships.

Methods

For three weeks in July 2020, nurses across the United States were invited to participate in an online survey collecting data on demographics, resilience, social support, and screening measures of depression, PTSD, anxiety, and distracted practice. Data were analyzed using descriptive statistics and hierarchical regression for each outcome measure.

Conclusions

Our findings support a growing body of research reporting that nurses are experiencing mental health sequelae during the COVID-19 pandemic, especially those providing direct care to patients with the virus. We found that compared to nurses who did not care for patients with COVID-19, those who did reported increased symptoms of PTSD, depression, and anxiety. A novel contribution is our finding that nurses providing direct COVID-19 care also experienced increased levels of distracted practice, a behavioral measure of distraction linking to a potential impact on patient care. We also found that resilience and social support acted as moderators of some of these relationships. Fostering resilience and social support may help buffer the effects of providing care to patients with COVID-19 and could potentially decrease nurse vulnerability to developing psychological symptoms and impairment on the job.
Does Preservation of Coracoacromial Ligament Reduce the Acromial Stress Pathology Following Reverse Total Shoulder Arthroplasty?
Authors: Baek, MD Chang Hee , Kim, MD Jung Gon , Lee, MD Dong Hyeon , Baek Gyu Rim
Published: June 2021

Introduction

Acromial pathologies (AP), such as acromial stress reaction (ASR), acromial stress occult fracture (ASOF), and acromial stress fracture (ASF), are known as complications that deteriorate the clinical score and patient satisfaction after reverse total shoulder arthroplasty (RSA). Several factors that increase stress on the acromion have been reported as risk factors for AP, but this is also unclear. Thecoracoacromial ligament (CAL) is a structure that distributes the stress loading on such an acromion, although its importance has been mentioned, there is a lack of research. Therefore, we investigated the incidence of AP according to the preservation of the CAL and whether it is a risk factor.

Methods

The study was retrospectively conducted on patients who underwent RSA from 2016 and 2018. Patients with CAL transection was classified into group 1 and CAL preservation was classified into group 2. ASR and ASOF were identified through symptoms and ultrasound, and ASF identified through simple radiograph or computed tomography. The incidence of AP in each group was checked and compared.

Results

Of the total of 265 patients. Among 197 cases of group 1, 21 cases of ASR(10.7%), 28 cases of ASOF (14.2%),10 cases of ASF (5.1%), and 59 cases of total AP (29.4%). Among 68 cases in group 2, 2 cases (2.9%) of ASR, 6 cases of ASOF(8.8%), 1 case of ASF (1.5%), and 9 cases of total AP (13.2%). It was confirmed that ASR and ASOP were significantly decreased in the group preserving CAL. (P = .008)

Conclusion

In the case of preservation of CAL during surgery, it was confirmed that the incidence of ASR, ASOF was reduced. Therefore, preservation of CAL can be regarded as a modifiable risk factor that can reduce the risk of AP by distributing the stress applied to acromion after RSA surgery.
Mutant VAPB: Culprit or Innocent Bystander of Amyotrophic Lateral Sclerosis?
Authors: Borgese Nica , Navone Francesca , Nukina Nobuyuki , Yamanaka Tomoyuki
Published: June 2021

Nearly twenty years ago a mutation in the VAPB gene, resulting in a proline to serine substitution (p.P56S), was identified as the cause of a rare, slowly progressing, familial form of the motor neuron degenerative disease Amyotrophic Lateral Sclerosis (ALS). Since then, progress in unravelling the mechanistic basis of this mutation has proceeded in parallel with research on the VAP proteins and on their role in establishing membrane contact sites between the ER and other organelles. Analysis of the literature on cellular and animal models reviewed here supports the conclusion that P56S-VAPB, which is aggregation-prone, non-functional and unstable, is expressed at levels that are insufficient to support toxic gain-of-function or dominant negative effects within motor neurons. Instead, insufficient levels of the product of the single wild-type allele appear to be required for pathological effects, and may be the main driver of the disease. In light of the multiple interactions of the VAP proteins, we address the consequences of specific VAPB depletion and highlight various affected processes that could contribute to motor neuron degeneration. In the future, distinction of specific roles of each of the two VAP paralogues should help to further elucidate the basis of p.P56S familial ALS, as well as of other more common forms of the disease.
Post-earthquake fast damage assessment using residual displacement and seismic energy: Application to Mexico City
Authors: Quinde Pablo , Terán-Gilmore Amador , Reinoso Eduardo
Published: June 2021

The simplicity, timeliness, and reliability of a post-earthquake assessment are fundamental for decision-makers in emergency management. An adequate risk assessment will help during the recovery and, therefore, increases the resilience of the community. Although within this context, the walk-down damage survey with the correct filling of evaluation forms and use of processing-data tools make possible a pertinent post-earthquake assessment, it is desirable to have measurable parameters that can complement the visual field evaluation with quantitative information. In some cases, basic quantitative measures, such as crack width, are not enough to make pertinent structural damage assessments. This article presents a fast and simple methodology to estimate the median maximum displacement and plastic energy demands on simple single-degree-of-freedom systems from the residual displacement they exhibit after being subjected to ground motions generated in the lakebed zone of Mexico City. Based on this, a discussion is offered on how a post-earthquake assessment can be improved by complementing the visual and measured information gathered on an existing structural system after an intense ground motion, with estimates of its maximum and cumulative plastic deformation demands derived from its residual deformation.
Whole-genome sequencing suggests a role of MIF in the pathophysiology of TEMPI syndrome
Authors: Sun Chunyan , Xu Jian , Zhang Bo , Huang Haifan , Chen Lei , Yan Han , Xu Aoshuang , Zhao Fei , Huang Daijuan , Liu Liqiong , Li Jian , Hu Yu
Published: June 2021

TEMPI syndrome (telangiectasias, elevated erythropoietin level and erythrocytosis, monoclonal gammopathy, perinephric fluid collections, and intrapulmonary shunting) is a newly defined multisystemic disease with its pathophysiology largely unknown. Here, we report the whole-genome sequencing (WGS) analysis on the tumor-normal paired cells from a patient with TEMPI syndrome. WGS revealed somatic nonsynonymous single-nucleotide variants, including SLC7A8, NRP2, and AQP7. Complex structural variants of chromosome 2 were found, particularly within regions where some putative oncogenes reside. Of potential clinical relevance, duplication of 22q11.23 was identified, and the expression of the located gene macrophage migration inhibitory factor (MIF) was significantly upregulated in 3 patients with TEMPI syndrome. Importantly, the level of serum MIF in one patient with TEMPI syndrome was significantly decreased in accordance with the downtrend of plasma cells, M-protein, hemoglobin, and erythropoietin and the improvement of telangiectasias, perinephric fluid collections, and intrapulmonary shunting after treatment with plasma cell–directed therapy. In conclusion, our study provides insights into the genomic landscape and suggests a role of MIF in the pathophysiology of TEMPI syndrome.
Correction to: An introduction to new robust linear and monotonic correlation coefficients
Authors: Tabatabai Mohammad , Bailey Stephanie , Bursac Zoran , Tabatabai Habib , Wilus Derek , Singh Karan P.
Published: June 2021

An amendment to this paper has been published and can be accessed via the original article.
Antioxidant activity of Lactobacillus plantarum NJAU-01 in an animal model of aging
Authors: Ge Qingfeng , Yang Bo , Liu Rui , Jiang Donglei , Yu Hai , Wu Mangang , Zhang Wangang
Published: June 2021

Background

Excessive reactive oxygen species (ROS) can cause serious damage to the human body and may cause various chronic diseases. Studies have found that lactic acid bacteria (LAB) have antioxidant and anti-aging effects, and are important resources for the development of microbial antioxidants. This paper was to explore the potential role of an antioxidant strain, Lactobacillus plantarum NJAU-01 screened from traditional dry-cured meat product Jinhua Ham in regulating D-galactose-induced subacute senescence of mice. A total of 48 specific pathogen free Kun Ming mice (SPF KM mice) were randomly allocated into 6 groups: control group with sterile saline injection, aging group with subcutaneously injection of D-galactose, treatments groups with injection of D-galactose and intragastric administration of 107, 108, and 109 CFU/mL L. plantarum NJAU-01, and positive control group with injection of D-galactose and intragastric administration of 1 mg/mL Vitamin C.

Results

The results showed that the treatment group of L. plantarum NJAU-01 at 109 CFU/mL showed higher total antioxidant capacity (T-AOC) and the antioxidant enzymatic activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) than those of the other groups in serum, heart and liver. In contrast, the content of the oxidative stress marker malondialdehyde (MDA) showed lower levels than the other groups (P < 0.05). The antioxidant capacity was improved with the supplement of the increasing concentration of L. plantarum NJAU-01.

Conclusions

Thus, this study demonstrates that L. plantarum NJAU-01 can alleviate oxidative stress by increasing the activities of enzymes involved in oxidation resistance and decreasing level of lipid oxidation in mice.
Most published meta-regression analyses based on aggregate data suffer from methodological pitfalls: a meta-epidemiological study
Authors: Geissbühler Michael , Hincapié Cesar A. , Aghlmandi Soheila , Zwahlen Marcel , Jüni Peter , da Costa Bruno R.
Published: June 2021

Background

Due to clinical and methodological diversity, clinical studies included in meta-analyses often differ in ways that lead to differences in treatment effects across studies. Meta-regression analysis is generally recommended to explore associations between study-level characteristics and treatment effect, however, three key pitfalls of meta-regression may lead to invalid conclusions. Our aims were to determine the frequency of these three pitfalls of meta-regression analyses, examine characteristics associated with the occurrence of these pitfalls, and explore changes between 2002 and 2012.

Methods

A meta-epidemiological study of studies including aggregate data meta-regression analysis in the years 2002 and 2012. We assessed the prevalence of meta-regression analyses with at least 1 of 3 pitfalls: ecological fallacy, overfitting, and inappropriate methods to regress treatment effects against the risk of the analysed outcome. We used logistic regression to investigate study characteristics associated with pitfalls and examined differences between 2002 and 2012.

Results

Our search yielded 580 studies with meta-analyses, of which 81 included meta-regression analyses with aggregated data. 57 meta-regression analyses were found to contain at least one pitfall (70%): 53 were susceptible to ecological fallacy (65%), 14 had a risk of overfitting (17%), and 5 inappropriately regressed treatment effects against the risk of the analysed outcome (6%). We found no difference in the prevalence of meta-regression analyses with methodological pitfalls between 2002 and 2012, nor any study-level characteristic that was clearly associated with the occurrence of any of the pitfalls.

Conclusion

The majority of meta-regression analyses based on aggregate data contain methodological pitfalls that may result in misleading findings.
The prevalence of HEV among non-A-C hepatitis in Qatar and efficiency of serological markers for the diagnosis of hepatitis E
Authors: Al Absi Enas S. , Al-Sadeq Duaa W. , Khalili Makiyeh , Younes Nadin , Al-Dewik Nader , Abdelghany Sara K. , Abouzid Somaia S. , Al Thani Asma A. , Yassine Hadi M. , Coyle Peter V. , Nasrallah Gheyath K.
Published: June 2021

Background

The rapid growth of Qatar in the last two decades has attracted a large influx of immigrant workers who mostly come from HEV-hyperendemic countries. Thus, we aim to investigate the prevalence of HEV among acute non-A-C hepatitis patients in Qatar; and to evaluate the performance of four dominant commercial serological assays for HEV diagnosis.

Methods

259 patients with non-A-C hepatitis were tested using the Wantai HEV-IgM, HEV-IgG, HEV-Ag ELISA kits, and the MP Biomedical HEV-Total Ab ELISA kit. ALT levels were tested and HEV RNA (viral loads) was performed using Taqman AmpliCube HEV RT-PCR kit (Mikrogen, Neuried, Germany). The performance of each kit was assessed according to the RT-PCR results.

Results

HEV-RNA was detected in 23.1% of the samples. Most of these HEV-RNA-positive cases belonged to non-Qatari residents from the Indian subcontinent; India, Pakistan, etc. HEV-Ag, HEV-IgM, HEV-IgG, HEV-Total Ab were detected in 5.56%, 8.65%, 32.1%, and 34.2% of all tested samples, respectively. Elevated ALT levels were highly correlated with the HEV-Ag, HEV-IgM, HEV-RNA but not with the HEV-IgG and HEV-Total Ab. Although HEV-Ag was very specific (100%), yet its sensitivity was poor (36.7%). HEV-IgM demonstrated the best second marker for diagnosis of acute HEV after RT-PCR as jugged by the overall performance parameters: specificity (96.2%), sensitivity (71.4%), PPV (83.3%), NPP (92.7%), agreement with RT-PCR (91.0%), and Kappa-value (0.71).

Conclusion

Our study demonstrated a high prevalence of HEV virus in Qatar, mostly among immigrants from the Indian subcontinent. The HEV-IgM represents the best marker for detecting the acute HEV infection, where RT-PCR cannot be performed.