bluuebunny/crossref_metadata_2025 huggingface dataset:
Toronto policy and missing middle housing: case studies for policy reform
Authors: Kuefler Brent
Published: February 2022

This paper examines how the Toronto Official Plan and zoning bylaw have limit the market from effectively responding to housing demand. These documents protect Toronto’s ‘stable’ neighbourhoods from increased density and restrict development of affordable missing middle housing forms which could provide ground-related housing in desired areas. Policy which limits housing options in existing communities has contributed to negative social, economic, and environmental outcomes within cities. Recognizing the negative impacts of exclusionary zoning, jurisdictions across North America are reforming policy and zoning bylaws to permit multi-unit housing in areas zoned for single-detached housing. This paper reviews reform processes in several jurisdictions and recommends that Toronto reform its Official Plan and zoning bylaw to permit increased housing options across the city, conduct outreach to change opinions on increased density, incentivize production of missing middle housing, and use land value capture tools to limit increases in land values brought about by rezoning.

KEYWORDS

missing middle housing, yellowbelt, stable neighbourhoods, Toronto, zoning
A City for All Seasons: Winter City Planning for Toronto’s Parks and Public Spaces
Authors: Petryshyn Nathan
Published: February 2022

Municipalities which identify as “winter cities”– those who design and plan for their cold climates and embrace the unique opportunities of the winter season, hold numerous social and economic advantages. Promoting and supporting seasonal design, community events, recreational opportunities, and year-round urban activity is shown to result in positive social and economic outcomes for municipalities. As a northern city, Toronto has taken steps through policy development, guidelines, and seasonal activities to encourage better use of public spaces throughout the winter season. Yet implementation of these ideas can go further. How might Toronto holistically embrace its climate and become a true “winter city”?

Case study comparisons to our North American counterparts and site analysis of Toronto’s downtown park spaces highlight that more might be done to improve urban winter living in Toronto, specifically via improved design and functionality of parks and public spaces during the cold season. If accomplished, the positive impacts associated with embracing the winter season and identifying as a winter city may occur in Toronto. In-depth literature review defines the winter city concept and the numerous benefits associated with embracing winter city design and planning principles.

Considering local municipal policy and understanding what is currently being achieved in other North American municipalities, winter city recommendations specific to Toronto’s parks and public spaces are developed. By implementing these recommendations, Toronto may

improve both new and existing parks and public spaces– places essential to the city’s function, full of social and economic opportunity, resulting in positive benefits for citizens, communities, and the city overall.
INFLUENCE INFLUENCE OF PARAMETERS ON 3D PRINTING PROCESS USING FILLAMENT EAL-FILL CONCERNING OF DIMENSIONAL ACCURACY AND HARDNESS WITH THE TAGUCHI METHOD APPROACH
Authors: Apriansyah Icvan , ZAMHERI AHMAD , ARIFIN FATAHUL
Published: February 2022

The presence of 3D printing technology in the world of manufacturing has brought big changes to the world. This technology, which is also known as Additive Layer Manufacturing, has actually been around since the 1980s. The emergence of 3D Printing technology is very influential in several industrial fields. Therefore this study was carried out to find out and increase knowledge about the eAl-fill fillament which will be tested using dimensional accuracy and hardness testing on the fillament using the Taguchi method.From the analysis of variance (ANOVA) states that the parameter that has the most influence on the dimension of accuracy is the layer height with a contribution value of 64.233%. Meanwhile, the most influential parameter of hardness is the print temperaure with a contribution value of 41.929%.
In Silico Study for Similar FDA Approved Drugs as Inhibitors of SARS-CoV-2 Spike and the Host Receptor Proteins
Authors: Shamkh Israa Mohamed , Pratiwi Dina , Omar Hanaa S. , Reyad Nour El-Houda A.
Published: February 2022

The severe acute respiratory syndrome coronavirus 2, known as COVID-19, has been hideously increased worldwide. The disease began in Wuhan, China, around December 2019, then spread to most countries. Social distancing is the best procedure to prevent infection. Screening the available database containing millions of drug molecules or phytochemicals has become rapid and straightforward because of the computer-aided drug design (CADD) methods. In the present study, 300 phytochemicals and cellulose ether derivatives are screened through a docking study. Docking analysis showed that only four molecules (a-neohesperidin, quercetin 3-O-glucosylrutinoside, 14-ketostypodiol diacetate, and hydroxypropyl methylcellulose) were able to interact with the spike protein. However, two among them (quercetin 3-O-glucosylrutinoside and 14-ketostypodiol diacetate) could interact with the host cell receptor (ACE2) of SARS-CoV-2. The binding affinity of the four compounds is high. Still, according to Lipinski's rule of five, only 14-ketostypodiol diacetate was selected as a drug molecule due to its pharmacokinetic and ADMET properties. Screening for drug analogs to the 14-ketostypodiol diacetate detected five approved drugs. Docking analysis of these drugs with the target proteins showed that the five drugs interact with the host receptor protein, and three interact with viral spike protein. Accordingly, we suggest that molecular docking and drug analogs studies could support rapid drug development. In addition, future perspectives on therapeutic applications of 14-ketostypodiol diacetate are required for using it against SARS-CoV-2 infections.
МЕТОДИ ПСИХОЛОГІЧНОЇ КОРЕКЦІЇ ПСИХОГЕННИХ ПОРУШЕНЬ УЧАСНИКІВ БОЙОВИХ ДІЙ В КОНТЕКСТІ МЕДИКО-ПСИХОЛОГІЧНОЇ РЕАБІЛІТАЦІЇ
Authors: Сторожук Н.
Published: February 2022

Стаття присвячена розгляду досвіду психологічної корекційної роботи з  психогенними порушеннями учасників бойових дій, які проходили процес  фізичного відновлення в госпіталі для ветеранів війни). Наведена статистика найбільш типових психогенних порушень військовослужбовців. Подана логіка психологічної корекційної роботи й відібрані  та апробовані психотерапевтичні методи роботи з психогенними порушеннями учасників бойових дій.
РОЗРОБКА ТА ЗМІСТ КОМПЛЕКСНОЇ ТРЕНІНГОВОЇ ПРОГРАМИ «РОЗВИТОК ТОЛЕРАНТНОСТІ ДО НЕВИЗНАЧЕНОСТІ ПРИ ПРИЙНЯТТІ РІШЕННЯ КОМАНДИРОМ В УМОВАХ НЕВИЗНАЧЕНОСТІ»
Authors: Черевичний С.
Published: February 2022

У статті представлено структуру та зміст комплексної тренінгової програми «Розвиток толерантності до невизначеності у командирів при прийнятті ними рішення в умовах невизначеності», висвітлено мету та завдання програми, що полягають у розвитку психологічних компонентів: когнітивного, емоційно-вольового та ціннісно-мотиваційного, детально розкрито зміст занять програми.
ЗМІНИ СТРУКТУРИ МОТИВАЦІЇ У ВІЙСЬКОВОСЛУЖБОВЦІВ ВІЙСЬКОВОЇ СЛУЖБИ ЗА КОНТРАКТОМ ПІСЛЯ УЧАСТІ В БОЙОВИХ ДІЯХ
Authors: Кравченко О.
Published: February 2022

У статті визначено зміни мотивації у військовослужбовців військової служби за контрактом після участі в бойових діях. Військовослужбовці, які не мають бойового досвіду, схильні спрощувати та романтизувати професійну діяльність військового. Для військовослужбовців, які були учасниками бойових дій, суттєве значення має джерело їх активності. Вони свідомо ставляться до обмеження впливу на них зовнішніх впливів, намагалися активно реалізовувати власну суб’єктність.
ДОСВІД ВИКОРИСТАННЯ КЕЙС-МЕТОДУ ПРИ ФОРМУВАННЯ ПРОФЕСІЙНИХ КОМПЕТЕНТНОСТЕЙ ВІЙСЬКОВОГО ПСИХОЛОГА
Authors: Сторожук Н. , Гаврюшенко В.
Published: February 2022

У статті розкривається потенціал використання кейс-методу при формування професійних компетентностей військового психолога. Наводяться приклади міні-кейсів, які використовуються під час викладання навчальної дисципліни “Індивідуальне консультування військовослужбовців та членів їх сімей” для формування спеціальних та та військово-спеціальних компетентностей щодо здатності майбутніми фахівцями здійснювати практичну діяльність (тренінгову, психотерапевтичну, консультаційну, психодіагностичну та іншу залежно від спеціалізації) та надавати психологічну допомогу.
РОЛЬ ЕМОЦІЙНОЇ КОМПЕТЕНТНОСТІ ОСОБИСТОСТІ В ПОДОЛАННІ ЕМОЦІЙНИХ БАР’ЄРІВ У СПІЛКУВАННІ
Authors: Тишакова Л. , Балабанова К.
Published: February 2022

Стаття присвячена дослідженню емоційної компетентності особистості та її ролі в подоланні емоційних перешкод в міжособистісному  спілкуванні. Метою дослідження є виявлення психологічних особливостей емоційної компетентності та їх зв’язку з емоційними бар’єрами  міжособистісного спілкування курсантської молоді. Проаналізовано теоретичні підходи до вивчення емоційної компетентності та наводяться емпіричні дані про вплив емоційних бар’єрів на ефективність комунікації курсантів, що знаходяться на різних курсах фахового навчання. Встановлено існування відмінностей між курсантами першого та випускного курсів в емоційній ефективності спілкування.
ОКРЕМІ СОЦІАЛЬНО-ПСИХОЛОГІЧНІ ПРОБЛЕМИ СТАРІННЯ
Authors: Воронова О. , Барчій М.
Published: February 2022

У статті проаналізовано погляди вітчизняних та зарубіжних науковців на соціально-психологічні  проблеми старіння. Висвітлено психологічні особливості людей похилого віку. Розглянуто основні підходи до вивчення старості та старіння; проблему ейджизму та чинники виходу на пенсію; питання активного старіння та передпенсійної підготовки. Виокремлено чинники, які впливають на адаптаційні процеси людини похилого віку до нової якості життя.
ПСИХОЛОГІЧНІ ОСОБЛИВОСТІ ПОЛІТИКО-ІДЕОЛОГІЧНОГО САМОВИЗНАЧЕННЯ
Authors: Свідерська О. , Чорній О.
Published: February 2022

Проаналізовано психологічні особливості політико-ідеологічного самовизначення особи в умовах політичної кризи й інституційних трансформацій сучасного українського суспільства. Визначено взаємозв’язки політичних орієнтацій, цінностей та потреби у соціальному схваленні.
Lightweight Rubberized Concrete Slabs for Sustainable Road Pavements Serving Non-Auto Traffic
Authors: Nazari Maryam , Tehrani Fariborz M. , Ansari Mojtaba
Published: February 2022

Non-auto transportation infrastructure, such as bicycle lanes and sidewalks, serves as an efficient means of public mobility. Improving the sustainable design and construction of the concrete slabs that compose such roads promotes environmental and economic benefits, spanning the usage of green sources of materials and reduced maintenance costs. In this study, an investigation into the application of recycled tires, also known as tire-derived aggregate (TDA), combined with rotary-kiln produced expanded clay (EC) as coarse aggregates in concrete, as well as their life-cycle cost assessment, are presented. The mechanical properties of concrete specimens with three different mix designs, i.e.,100% EC (MIX A or control mix), a mixture of 20% EC – 80% TDA (MIX B), and 100% TDA (MIX C) as coarse aggregates, were first derived through experimental tests. Impact-fatigue tests were then conducted on concrete slabs of MIX A, B, and C to evaluate their sustainability under several cycles of bicycle loads. The results showed that the TDA concrete has lower compressive and flexural strength, but it is more ductile than concrete with zero rubber content. Also, the results of impact-fatigue tests combined with a life-cycle cost analysis indicated the long-term benefits of constructing green and durable infrastructure using TDA on future investments in transportation.
Вплив олігопептидів – гомологів фрагмента АКТГ15–18 на прооксидантно-антиоксидантний баланс у печінці щурів на моделі гострої гіпотермії
Authors: Кудіна О. В. , Штриголь С. Ю. , Сліпцова Н. А. , Пальчак Л. М. , Колобов О. О.
Published: February 2022

Ураження організму низькими температурами є актуальною проблемою медицини. Лікарські препарати для підвищення резистентності організму до впливу гіпотермії впливають на обмежену кількість ланок патогенезу холодової травми. З урахуванням складності патогенезу гіпотермічних уражень закономірний інтерес являють нейропептиди, здатні виявляти поліфункціональність. Мета дослідження – з’ясувати вплив олігопептидів – гомологів фрагмента АКТГ15–18 на перебіг процесів пероксидного окиснення ліпідів у печінці щурів на моделі гострої холодової травми.Прооксидантно-антиоксидантний баланс досліджували на моделі гострої холодової травми (експозиція тварин 2 год за –18 °С). Олігопептиди та препарат порівняння семакс вводили інтраназально в дозі 20 мкг/кг. Для оцінки впливу досліджуваних речовин на перебіг процесів пероксидногоокиснення ліпідів у печінці щурів визначали вміст ТБК-активних продуктів, відновленого глутатіону, активність каталази та супероксиддисмутази. Досліджувані пептиди статистично значуще перешкоджали розвитку гіпотермії. Холодова травма спричинила порушення прооксидантно-антиоксидантного балансу в печінці щурів. Цей стан характеризувався підвищенням рівня ТБК-активних продуктів у тварин групи контрольної патології в 2,8 разу проти показника інтактних щурів, зниженням рівня відновленого глутатіону в 1,4 разу, зменшенням активності каталази на 13 % і підвищенням активності супероксиддисмутази на 19 %. Олігопептиди та препарат порівняння знижували рівень ТБК-активних продуктів у 1,5 разу (пептид КК-1) і в 2,0 разу (пептид КК-5 і семакс). За нормалізацією вмісту відновленого глутатіону досліджувані пептиди КК-1 і КК-5 перевершували референс-препарат, оскільки вірогідно підвищували цей показник у 1,2 і 1,3 разу відповідно. Під впливом обох пептидів активність каталази підвищилась на 15 % проти показника контрольної патології. Активність супероксиддисмутази не мала значних змін під впливом як пептидів КК-1 і КК-5, так і семаксу.Таким чином, встановлено, що на моделі гострої холодової травми олігопептиди – гомологи фрагмента АКТГ15–18 виявили фригопротекторні й антиоксидантні властивості, запобігаючи розвитку гіпотермії та нормалізуючи прооксидантно-антиоксидантний статус у печінці щурів.
Schemi Attuali Di Terapia Con Calcitriolo
Authors: Zoccali C.
Published: February 2022

Abstract non disponibile
Rischio Di Neoplasie Nei Pazienti in Dialisi
Authors: Ragni R.
Published: February 2022

Abstract non disponibile
Valutazione Dello Stato Nutrizionale Con l'uso Dell'impedenziometria
Authors: Zazzaro D. , Sturniolo A. , Piccinni G. , Splendiani G.
Published: February 2022

Abstract non disponibile
Diagnosi di Linfoma Tramite Citologia Del Ouido Peritoneale in un Paziente in Dialisi Peritoneale Amhulatoria Continua
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
Organizzazione Dell'ambulatorio e Del Day-Hospital Nefrologici in un Comprensorio di 70.000 Abitanti: Strutture, Strumenti, Personale
Authors: Di Paolo N. , Garosi G. , Guarnieri A.
Published: February 2022

Abstract non disponibile
Aspetti Clinici Ed Epidemiologici Dell'epatite C Nei Pazienti in Emodialisi
Authors: Di Iorio B. , Gaudiano G. , Altieri C. , Terracciano V.
Published: February 2022

Abstract non disponibile
Anatomia Del Rene in Ecotomografia
Authors: Pittavini L. , Nunzi E. , Quintaliani G. , Demegni L. , Buoncristiani U.
Published: February 2022

Abstract non disponibile
Diagnostica Ecografica Delle Nefropatie Mediche
Authors: Conti P.
Published: February 2022

Abstract non disponibile
P-ANCA Senza Positività per Anticorpi Anti-Mieloperossidasi (ANTI-MPO): Associazioni Cliniche
Authors: Gregorini G. , Tira P. , Gorla R. , Prati E.
Published: February 2022

Abstract non disponibile
L'ecografia Renale Nello Studio Del Paziente Con Insufficienza Renale Cronica
Authors: Zanazzi M. , Scarpioni R.
Published: February 2022

Abstract non disponibile
Fistola Arterovenosa Carotido-Giugulare: Una Complicazione Del Catetere Temporaneo per Emodialisi
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
Terapia ecoguidata delle cisti renali
Authors: Balconi G.
Published: February 2022

Abstract non disponibile
L'elaborazione dei dati computerizzati come ausilio alle decisioni medico infermieristiche
Authors: Castelnuovo D. , Bacchini G. , Pontoriero G. , Pozzoni V. , Todeschini M. , Andreoli M.
Published: February 2022

Abstract non disponibile
La foto del mese
Authors: Di Paolo N , Capotondo L.
Published: February 2022

Abstract non disponibile
Il Caso Clinico: Grave Ipouricemia Renale Secondaria a Iperbilirubinemia
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
La Foto Del Mese
Authors: N Di Paolo , L Capotondo , G Garosi
Published: February 2022

Abstract non disponibile
Prescrizione e Valutazione Nel Tempo Della Dose Dialitica Con Test di Equilibrio Specifico Per La Dialisi Peritoneale Tidal
Authors: Edefonti A. , Picca M. , Consalvo G. , Ghio L. , Giani M. , Damiani B. , Dal Col A. , Galato R.
Published: February 2022

Abstract non disponibile
Il Punto Di Vista Di Tn&d
Authors: Lombardi M.
Published: February 2022

Abstract non disponibile
Biopsia Renale Complicata Da Ematoma Perirenale Induce Riacutizzazione Di Lupus Eritematoso Sistemico: Due Casi
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
Rassegna Della Letteratura Recente
Authors: Monaci G. , Brardi S.
Published: February 2022

Abstract non disponibile
Peritonite Da Fusarium in un Bambino in Dialisi Peritoneale: Case Report e Review Della Letteratura
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
La Foto Del Mese
Authors: Brendi F. , Bassi S. , Poieiti P. , Terdenico R.
Published: February 2022

Abstract non disponibile
Inserzione Del Catetere Peritoneale: Esperienza Personale
Authors: Favazza A. , Boscutti G. , Mioni G.
Published: February 2022

Abstract non disponibile
Il Ricircolo Nell'accesso Vascolare Per Emodialisi
Authors: Calzavara P.
Published: February 2022

Abstract non disponibile
Panorama Del Tecnico Di Dialisi
Authors: Tagliavini D.
Published: February 2022

L'A.N.T.E. (Associazione Nazionale Tecnici di Dialisi), ha accettato il nostro invito a collaborare con una propria Rubrica al Giornale di Tecniche Nefrologiche e Dialitiche.
Questa iniziativa è per noi molto importante: è indispensabile che i Tecnici abbiano la possibilità di far sentire la propria opinione, vuoi in campo scientifico oppure più semplicemente in campo tecnico, se non addirittura per temi di carattere etico o sindacale. Siamo infatti convinti che ormai la figura del Tecnico di Dialisi debba ritenersi distaccata dalla funzione dell'infermiere professionale, sia perché la professionalità del primo è necessariamente superiore, sia perché le varie problematiche lavorative differiscono in modo evidente. Da anni lavoriamo per l'aggiornamento del Tecnico di Dialisi, obiettivo indispensabile per la tumultuosa evoluzione tecnica della nostra specialità, ma è ormai giunto il momento, come avviene ormai negli stati Uniti, che il Tecnico cominci a partecipare direttamente alla propria evoluzione.
Il Direttivo dell'A.N.T.E è conscio di questa priorità e ha compreso che è indispensabile una stretta collaborazione fra Tecnici e Nefrologi. In questo numero oltre la nuova Rubrica, viene pubblicato un lavoro i cui Autori sono un Nefrologo ed un Tecnico di Dialisi: vogliamo auspicarci che sia il primo di tanti. La Rubrica invece è aperta a tutti quelli che hanno da dire qualsiasi cosa di carattere tecnico scientifico, sindacale, che vogliano suggerire miglioramenti ai Corsi di Aggiornamento ed alla stessa Rivista; tutti potranno anche inserirsi scrivendo alla Redazione della Rivista, apportando i loro punti di vista su tutte le questioni che verranno discusse. Sarà pubblicato tutto, salvo ciò che possa risultare necessario di censura.
Invitiamo quindi tutti a partecipare attivamente alla vita di questa nuova Rubrica “Panorama del Tecnico di Dialisi” che ci auguriamo possa raggiungere lo scopo di creare una rete di collegamento fra i Tecnici e fra Tecnici e Nefrologi, tenendo presente che la Rivista raggiunge gli organi ministeriali, regionali, delle singole Usl e quindi diventa automaticamente una voce autorevole nel campo della nostra specialità.
Le Alterazioni Del Metabolismo Lipidico Nell'uremia: Dalle Fasi Precoci Della Insufficienza Renale Cronica Alla Dialisi
Authors: Bergesio F. , Monzani G. , Ciciani A.M. , Ciuti R. , Serruto A. , Rosati A. , Piperno R. , Tosi P.L. , Bandini S. , Salvadori M.
Published: February 2022

Abstract non disponibile
Vantaggi Clinici Nella Valutazione Dell'urea. Ruolo Del Monitoraggio Mediante Biosensore
Authors: Bazzato G. , Saccoman F.
Published: February 2022

Abstract non disponibile
La Foto Del Mese
Authors: Collini A. , Vuolo G. , Attardi A.M.
Published: February 2022

Abstract non disponibile
Il Caso Clinico: Giovane uomo con insufficienza renale acuta e severo dolore lombare
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
Influenza Del Calcio Sulla Morfologia Degli Eritrociti Urinari
Authors: Ballestri M. , Baraldi A. , D'Amelio A. , Bonucchi D.
Published: February 2022

Abstract non disponibile
L'Accumulo Di Alluminio Nei Pazienti Uremici
Authors: Masti A. , Di Paolo M. , Barni Comparini I. , Centini F.
Published: February 2022

Abstract non disponibile
Manifestazioni Extrarenali Nella Malattia Renale Policistica Autosomica Dominante
Authors: Sessa A. , Conte F. , Serbelloni P. , Milani S.
Published: February 2022

Abstract non disponibile
La Foto Del Mese
Authors: Lombardi Marco , Sisce Sergio , Taddei Aldo , Pepp Stefano
Published: February 2022

Abstract non disponibile
Rassegna Della Letteratura Recente
Authors: Brardi S.
Published: February 2022

Abstract non disponibile
Sintomatologia in Emodialisi e Possibili Cause
Authors: Virga G. , Mastrosimone S. , Amici G. , Munaretto G. , Gastaldon F. , Bonadonna A.
Published: February 2022

Abstract non disponibile
Caratteristiche, Prevalenza e Fattori Di Rischio Del Diabete Mellito Post-Trapianto Renale
Authors: Di Maria L. , Moscarelli L. , Zanazzi M. , Rosati A. , Bertoni E. , Salvadori M.
Published: February 2022

Abstract non disponibile
L'iperparatiroidismo Secondario: Linee Guida Per Il Trattamento Ed Effetti a Lungo Termine Della Terapia Con Calcitriolo Endovena L'iperparatiroidismo Secondario: Linee Guida Per Il Trattamento Ed Effetti a Lungo Termine Della Terapia Con Calcitriolo Endovena
Authors: Farina M. , Malberti F. , Corradi B. , Cosci P. , Mandolfo S. , Imbasciati E.
Published: February 2022

Abstract non disponibile
Il Caso Clinico
Authors: Garosi G.
Published: February 2022

Abstract non disponibile
Valutazione Dello Stato Nutrizionale in Pazienti Emodializzati: Ruolo Dell'Analisi Bioimpedenziometrica
Authors: Chiappini M.G. , Ammann T. , Monno D. , Selvaggi G. , Traietti P.
Published: February 2022

Abstract non disponibile
Meig's Syndrome with an Elevated CA125 in a 15-Year-Old Girl
Authors: Maqbool Adil , Jesmin Subrina , Arif Ifra
Published: February 2022

Background: An increased CA 125 in conjunction with a pelvic mass is, although, strongly indicative of ovarian cancer, there are a number of other benign diseases that may be linked to a pelvic mass and a higher CA 125. Meigs syndrome is an uncommon condition in women under the age of 30. It consists of a triad of benign fibrous ovarian tumors, ascites, and pleural effusion. When the tumor is removed, the symptoms got resolve completely within two weeks. Case Presentation: It is a case of a 15-year-old girl with fibroma, along with a review of the literature. Although the cause of the fluid accumulations is unknown, it seems to be linked to lymphatic blockage. Abdominal distension, pain, cough, pleuritic chest pain, vomiting, fever, and weight loss are all presenting symptoms. Conclusion: This case report concludes that although a pelvic mass with elevated CA 125 is strongly indicative of malignancy, other illnesses, particularly Meigs syndrome and pseudo-Meigs syndrome in young women presenting with a pleural effusion, should always be evaluated as a differential diagnosis. The fluid buildup typically disappears within two weeks of the tumor being removed.
Uterine Leiomyoma in Postmenopausal Women: Possible Reasons for Growth and Differential Diagnosis
Authors: Shigeta Hiroyuki , Asano Ryoko , Oi Yuka , Katayama Kayo , Ishidera Yumi
Published: February 2022

Background: Uterine leiomyomas appear after menarche, typically grow during the reproductive years, and then stabilize or regress after menopause. However, there have been several reports of a considerable number of patients who have undergone surgery for uterine leiomyomas during the postmenopausal period. In this paper, we discuss two issues: the possible reasons for the growth of uterine leiomyomas and the differential diagnoses of presumed leiomyomas in postmenopausal women. Methods: PubMed was searched for studies about uterine leiomyomas and sarcomas with a focus on postmenopausal women. Main findings: Several hypotheses exist for the growth of postmenopausal leiomyomas. Among these, we propose the following as an important candidate: estrogen and progesterone do not necessarily work in a positive way. In addition, in postmenopausal patients, the incidence of malignant tumors is very high, and it is generally difficult to diagnose uterine sarcoma prior to surgery. Conclusion: We propose that in cases in which uterine sarcomas cannot be ruled out, physicians should proactively consider surgery, particularly for postmenopausal patients.
Association of Body Mass Index with Chronic Conditions and Procedures in General Medicine Clinics at an Academic Health Center
Authors: Jackson J. Brooks , Wendt Linder , Eyck Patrick Ten
Published: February 2022

Objectives: Determine the prevalence of obesity in an adult patient population at an academic health center, and determine the association between body mass index (BMI) with type 2 diabetes, hypertension, coronary stent placement, joint replacement, and spinal fusion procedures stratified by age and sex. Methods: Patient age, sex, BMI, and disease conditions/procedures for 51,435 adult patients seen since 2015 at either the family medicine clinic or general internal medicine clinic were obtained from the electronic health record using ICD-10 codes. A logistic regression analysis was performed with and without adjusting for the impact of age and sex. Odds ratios were calculated using both the adjusted and unadjusted models. Results: The percentage of patients with a BMI in the healthy weight range, overweight range, and obesity categories was 28.5%, 31.3%, and 40.2%, respectively. The percent of adult patients with obesity steadily increased with age and peaked in the 49-54 age group at 49.5% for women and 46.9% for men, and then decreased with age. The odds ratios (both adjusted and unadjusted) indicated that individuals with greater BMI measurements are at significantly greater risk of type 2 diabetes (odds ratio 1.096), hypertension (odds ratio 1.097), coronary stent (odds ratio 1.051), and joint replacement (odds ratio 1.051), while no statistically significant relationship between spinal fusion and BMI was identified (odds ratio 1.014). Conclusions: Our findings support the increasingly high prevalence of obesity in American society, the significant associations of obesity with chronic conditions and surgical/medical procedures, and the need for effective prevention and treatment interventions.
Is The Risk of Thromboembolic Disease and Bleeding Adequately Evaluated in Patients with Glioblastoma? A Review of The Topic
Authors: Vedia Iris Violeta De la Rocha , Sánchez José Portillo
Published: February 2022

Introduction: Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor, with an aggressive course and a short life expectancy despite standard treatment (chemotherapy and radiotherapy). The possibility of the development of thrombotic events (VTE) with this type of cancer is frequent. Objective: To determine the risk of presenting VTE and haemorrhagic events in patients affected by GBM. Methods: Observational retrospective study of patients with GBM diagnosis at the General University Hospital of Ciudad Real between 2012 and 2015. The demographic characteristics of patients were studied, predictive models were compared, and a survival analysis was performed. Results: 77 patients were studied, 42 (55.3%) / 34 (44.7%), men and women respectively, with an average age of 66.42 years. 13 (16.9%) presented VTE; of which 10 (61.54%) in the form of deep venous thrombosis (DVT), 3 (23.08%) pulmonary embolism (PE) and 2 (15.38%) mixed events. The quality of life according to the performance status ECOG scale at the moment of diagnosis was 1 in 42 (15.38%) patients, and at the time of VTE, 5 (41.7%) had a value of 2, and 4 (33.3.3 %) registered 3. In the group that developed VTE according to the predictive model of risk for thrombosis in Khorana 5 (38.5%) had low risk and 8 (61.5%) intermediate; on the ASCO 2013 modified scale 5 (38.5%) had an Intermediate risk and 8 (61.5%) high. With a median, 1 year follow-up, 64 (84.2%) patients died, with an average time after the diagnosis of 279.09 days (216.6-341.6) (SE 31,8). 2 (2.6%) of the patients presented a greater haemorrhagic event and 7 (7.9%) cerebral haemorrhage, of which 4 (44.4%) had prophylactic Low molecular weight heparins (LMWHs). In the survival analysis of Kaplan Meyer, patients who received prophylactic treatment with LMWHs had a higher survival rate with an average of 298.5 days compared to 239.3 of those who did not (p> 0.05). There were no significant variables in the multivariate analysis for thrombotic or haemorrhagic events. Conclusion and Discussion: The demographic and clinical characteristics of our patients were similar to those reported in other international publications. The predictive scale of Khorana was not validated in our study, in contrast, the modified ASCO 2013 scale was closer to our results. The creation of a precise predictive model would help to delineate the benefit of prophylactic anticoagulation in high-risk patients. Long-term prophylaxis with LMWHs has demonstrated a reduction of thrombotic events without significantly increasing the fatal haemorrhagic episodes, also demonstrating greater long-term survival, independent of thrombotic events. Randomized prospective studies are needed to demonstrate its benefits.
Agarose and Wax Tissue-Mimicking Phantom for Dynamic Magnetic Resonance Imaging of the Liver
Authors: Ahmad Muntaser S. , Makhamrah Osama , Suardi Nursakinah , Shukri Ahmad , Razak Nik Noor Ashikin Nik Ab , Mohammad Hjouj
Published: February 2022

Objectives: Polymer phantoms can be used to simulate the properties of tissues or organs such as the liver during magnetic resonance imaging (MRI). Although there are reports of simulated liver phantoms with hepatocellular carcinoma (HCC); no studies have documented the simulating of the typical dynamic pattern. Aim: The present study aimed to investigate properties of developed phantoms with respect to the stability, including chemical, mechanical, electrical, as well as MRI properties (T1- and T2- signal intensities), in addition to simulating HCC in a dynamic way. Methods: In this study, liver parenchyma of size 23 ×18 ×13 cm was simulated using three different agarose-wax samples (agarose at concentrations of 2.5 wt%, 4.5 wt%, and 6.0 wt%) mixed with a fixed wax concentration of 2.6 wt%.. HCC samples were fabricated using polyurethane and glycerol of various diameters (0.5, 1.0, and 2.0 cm). Results: The results showed that the agarose-wax sample with a concentration of 2.5 wt% was the most stable sample among the other samples (P-value, 0.468) in mechanical and T1 and T2 intensities. It was also noted that the sample at the concentration of 4.5 wt% had the closest density value to human liver with a difference of 7.88%. Moreover, the agarose-wax sample at a concentration of 2.5 wt% had the closest compressibility and conductivity values, and T1-relaxation time compared to the human liver. However, the largest changes in relaxation times were observed in the fifth week of all samples (P-value = 0.047). The typical enhancement pattern for a simulated HCC of a minimum size, which can be measured with MRI, was 1.0 cm, using a body coil, and 0.5 cm using a head coil. Conclusions: The chemical, electrical density, compressive strength, density, and MR imaging properties of the phantom were measured and compared to those of the human body.
Bacterial Vaginoses caused by Gardnerella vaginalis at Thiès Regional Hospital: Study of Clinic-Biological Aspects
Authors: Diagne Rokhaya , Ngom Babacar , Lawson Tevi , Thiam Marietou , Moussa Naimatou , Mbodji Mamadou , Ka Roughyatou , Niang Aissatou , Sarr Habibou , Dieye Baidy , Sow AI
Published: February 2022

Introduction: Bacterial vaginosis is a frequent infection among women. The aim of this study is to make an evaluation of the prevalence of infections caused by Gardnerella vaginalis among women who underwent vaginal tests in the laboratory of Biology of Thies Regional hospital... Our study intends to elucidate and define the characteristics of vaginal exudate in this condition, but also to evaluate the diagnostic criteria in force at the laboratory level. Materials and Methods: It is about a retro-prospective study over two years between July 31st 2017 and July 31st 2019 among women from whom vaginal samples were taken. Our study population concerned all female outpatients or hospitalized consultants at the Regional hospital of Thiès during the study period. The secretions are collected at the level of the vaginal walls or at the level of the posterior fornix with a sterile swab, trying to bring back as much secretion as possible. Macroscopic and microscopic examinations and the identification of the germs involved were carried out. Results: Out of a total of 2376 vaginal samples, we observed a frequency of 25.5% of vaginosis caused by Gardnerella vaginalis.70.72% presented with white-haired leuchorrhoea, 35.69% presented with fetid leuchorrhea.Very rare leukocytes were found in 74.34% and 24.51% with cervicitis associated with vaginosis. Conclusion: Vaginosis caused by Gardnerella vaginalis is a frequent condition especially among women of childbearing age. It can lead to severe gynecological and obstetric complications. For better management, strengthening laboratory diagnosis is necessary.
EVALUASI PENERAPAN SISTEM MANAJEMEN MUTU ISO 9001 : 2015 DI PPEI
Authors: Rahayu Sri
Published: February 2022

Mutu diklat dari waktu ke waktu harus semakin meningkat. Peningkatan mutu diklat ditentukan oleh banyak faktor. Namun salah satu faktor kunci peningkatan mutu diklat adalah   bagaimana  pengelolaan pelaksanaan diklat berpengaruh untuk menghasilkan diklat yang baik. Dalam rangka peningkatan mutu diklat agar senantiasa memenuhi kepuasan pelanggan dan stakeholder terkait,  PPEI telah menerapkan sistem manajemen mutu dengan diterimanya sertifikat Sistem Manajemen Mutu ISO 9001 sejak tahun 2004. Sistem manajemen mutu  atau Quality Management System  pertama kali diperkenalkan oleh International Organization for Standardization (ISO) yang telah diadopsi di Indonesia melalui Badan Standardisasi Nasional (BSN)  sebagai SNI ISO 9001: 2015. Standar ini merupakan salah satu standar acuan untuk organisasi dalam penerapan sistem manajemen mutu. Melalui penerapan sistem manajemen mutu  diyakini bahwa pengelolaan barang atau jasa yang dihasilkan oleh suatu organisasi bermuara pada pemenuhan persyaratan mutu  pelanggan.Tujuan penelitian ini adalah mengevaluasi penerapan Sistem Manajemen Mutu ISO 9001 di PPEI. Metodologi penelitian dilakukan dengan cara observasi, wawancara dan studi dokumentasi. Hasil penelitian menunjukkan bahwa pengukuran analisis klausul terhadap pemenuhan persyaratan SMM 9001: 2015, untuk klausul 4 dan 5 adalah 95,00% dan  86,67%. Hal ini menunjukkan bahwa penerapan klausul 4 dan 5 di PPEI sudah sesuai dengan persyaratan standar sistem manajemen mutu. Sementara  pengukuran analisis klausul terhadap pemenuhan persyaratan Sistem Manajemen Mutu 9001: 2015,  untuk   klausul  6, 7, 8, 9 dan 10 adalah 70% - 80%. Hal ini menunjukkan bahwa sistem manajemen mutu ada, dokumentasi ada dan terorganisir dengan baik namun penerapan klausul 6, 7, 8, 9 dan 10 tidak dilakukan secara penuh di perusahaan/organisasi.
PENGARUH TINGKAT PENDIDIKAN TERHADAP PENINGKATAN KINERJA PEGAWAI PADA BADAN KESATUAN BANGSA DAN POLITIK PROVINSI SULAWESI SELATAN
Authors: Muhammad Maulana , F. Tonapa Jessica
Published: February 2022

Pencapaian prestasi kinerja pegawai Badan Kesbangpol Provinsi Provinsi Sulawesi Selatan pada kurun 3 tahun terakhir menunjukkan presentase yang tidak terlalu stabil dimana faktor tingkat pendidikan jajaran pegawai yang beragam menjadi hal yang perlu untuk diperhatan. Pada tahun 2017 dan 2018 presentase capaian kinerja berkategori cukup tinggi sedangkan pada tahun 2019 berkategori sedang. Tujuan penelitian ini ialah untuk mengetahui pengaruh tingkat pendidikan terhadap peningkatan kinerja pegawai. Metode Kuantitatif digunakan pada penelitian ini dengan tipe asosiatif untuk mengetahui pengaruh antara dua variabel. Data dikumpulkan melaluikuesioner,observasi dan dokumentasi. Sampel dalam penelitian ini adalah keseluruhan populasi penelitian, dan jumlah sampel yang menggunakan teknik sampling jenuh sebanyak 48 responden. Dalam penelitian ini teknik analisis data yang digunakan ialah analisis regresi linear sederhana, uji prasyarat analisis dan pengujian hipotesis. Hasil penelitian menunjukkan bahwa tingkat pendidikan berpengaruh positif dan signifikan terhadap peningkatankinerja pegawai dengan presentase sebesar  24%. Kecakapan intelektual yang diperoleh dari jenjang pendidikan sebaiknya juga diiringi dengan adanya upaya lain seperti pengembangan kompetensi dalam menunjang peningkatan kinerja.
Tissue specific and variable collagen proliferation in Swiss albino mice treated with clenbuterol
Authors: Patiyal SN , Katoch SS
Published: February 2022

Chronic administration of clenbuterol, a beta-adrenoceptor agonist (2 mg/kg body weight/day for 30 days) to mice resulted in an increased body mass. Measurement of dry tissue mass suggested a protein anabolic effect in the gastrocnemius and heart. Quantitative estimation of collagen content, a non-contractile element as calculated from hydroxyproline assay revealed its proliferation in the gastrocnemius, cardiac ventricle, intestine and to some extent also in the kidney. Clenbuterol did not induce collagen proliferation in non-muscle tissues such as the lungs and liver. Histopathological examination of sections from treated ventricles showed an extensive collagen infiltration in the subendocardium and at myonecrosis sites.
Imbalance between apoptosis and proliferation causes late radiation damage of salivary gland in mouse
Authors: Muhvic-Urek M , Bralic M , Curic C , Pezelj-Ribaric S , Borcic J , Tomac J
Published: February 2022

Severe xerostomia is a common late radiation consequence, which occurs after irradiation of head and neck malignancies. The aim of the present study was to analyze apoptosis and proliferation and their relationship during the late post-irradiation phase. C57BL/6 mice were locally irradiated in head and neck region with a single dose of 7.5 or 15 Gy and their submandibular glands were collected at 40 and 90 days after irradiation. To identify apoptotic cells, the TUNEL method was employed and immunohistochemistry with proliferating cell nuclear antigen (PCNA) was used for detecting proliferation. Histological changes at day 40 were mild in contrast to day 90 when glands of irradiated mice showed severe atrophy, vacuolization and mononuclear infiltration. Acinar cells, granular and intercalated duct cells of mice irradiated with 7.5 and 15 Gy expressed higher apoptotic index than cells of non-irradiated, control glands at both examined time points. At 40 days, a higher proliferation index in granular and intercalated duct cells was detected only in group irradiated with 7.5 Gy. At 90 days, proliferation index for all cell types in both irradiated groups was similar to the controls. According to our results, the imbalance between apoptosis and proliferation caused by X-irradiation may be the reason for gland impairment during the late post-irradiation phase.
Long-term monitoring of the changes in signal-averaged ECG after coronary artery occlusion and intracoronary endothelin-1 injection in dogs
Authors: Hubka P , Bernadič M , Hulín I
Published: February 2022

Myocardium undergoes functional changes in the infarcted region primarily due to ischemia. Following myocyte functional alterations of the noninfarcted myocardium are caused by remodelling and hypertrophy. We have monitored and compared changes in the electrocardiographical (ECG) image after coronary artery occlusion (CAO, n=5) and intracoronary endothelin-1 (ET-1, n=3) administration during a 6-month period. In 3 dogs, the CAO was repeated 6 months after the first occlusion. Signal-averaged ECG (SA ECG) was recorded before the operation and 10 days, 1 month, 3 months and 6 months after myocardial infarction (MI). The modified Wigner distribution was used for spectrotemporal analysis of the SA ECG. Eight-hour Holter monitoring was performed in each dog before and after experimental MI. Spectrotemporal representations of the QRS complex were stabilized after the first 1-month period in the group of dogs after CAO. The same results were also observed after the repeated CAO. No arrhythmias were recorded 9 days after CAO. The spectrotemporal representations of the QRS complex after intracoronary ET-1 administration were not stabilized during the whole observed period. Very few arrhythmic events were recorded by Holter monitoring already 3 days after intracoronary ET-1 injection. Experimental MI induced by CAO caused a changed ECG image, which was stable from 1 month after MI induction till the end of the monitoring. However, the ECG image after ET-1 administration was not stable during the whole observed period. No arrhythmic events were recorded in either group 3 months postoperatively that could be caused by healthy myocardial status before the experimental MI induction. In clinical practice, however, ischemic heart disease usually precedes the MI. Arrhythmogenic substrate could thus be a consequence of combination of healthy status of the myocardium before MI and MI itself.
How short-term transdermal treatment of men with 7-oxo-dehydroepiandrosterone influences thyroid function
Authors: Hampl R , Šulcová J , Bílek R , Hill M
Published: February 2022

Dehydroepiandrosterone may influence thyroid function. Its metabolite, 7-oxo-dehydroepiandrosterone, a precursor of immunomodulatory 7-hydroxylated metabolites and thermogenic agent, belongs to candidates of steroid replacement therapy. The question was addressed whether its application does influence laboratory parameters of thyroid function. 7-Oxo-dehydroepiandrosterone in the form of emulgel, 25 mg/day, was applied transdermally to 21 healthy men for 8 consecutive days. Morning blood was collected before the treatment (Day 0, Stage 1), during treatment (Day 5, Stage 2), on the first day after the last administration (Day 9, Stage 3), one week (Day 16, Stage 4), and 9 weeks (Day 72, Stage 5) after treatment termination. The levels of thyrotropin, free thyroxine and triiodothyronine, dehydroepiandrosterone, its sulfate and its 7-hydroxyepimers were measured. The changes were evaluated by analysis of variance and correlation analysis. During treatment a significant rise of 7beta-hydroxy-dehydroepiandrosterone was observed, which persisted 1 week after treatment termination. No changes were observed in dehydroepiandrosterone and its sulfate. Though a slight but significant rise of TSH and of both thyroid hormones occurred during treatment, its levels soon returned to the basal values. It was concluded that treatment of 7-oxo-dehydroepiandrosterone affects the thyroid parameters only temporarily and that it provides a considerable persistent amount of 7beta-hydroxy-dehydroepiandrosterone.
Air Evacuation of Citizens During the COVID-19 Epidemic
Authors: Gomes Elga Dias , Ronconi Michelle Abati Bordeaux Rego , Santos Mônica Barreto , Pires Júnior Paulo , Franco Aline Zandomeneghe Pereira , Fernanda Haberland Débora , Borges Letícia Lima
Published: February 2022

BACKGROUND: The coronavirus epidemic originated in China, having its epicenter in Wuhan. This was the first place in the world to adopt social distancing measures to contain the disease on January 23rd, 2020. After the initial isolation, several countries started making
diplomatic plans to evacuate and repatriate their citizens, with the permission of the Chinese authorities. Due to the high risk of exposure of the transported passengers, evacuations were conducted with preventive measures against contamination by biological agents.CASE REPORT:
We report the air evacuation of 39 passengers from China to Brazil. Five passengers were transported to Poland and the remaining 34 went to Brazil, where they remained in quarantine for 14 d. The mission was triggered on February 4th, named “Operation Return to Brazil”
(Operação Regresso à Pátria Amada Brasil), and conducted by military personnel of the Brazilian Air Force. The mission was accomplished in 6 days; the flight from Wuhan lasted 25 h 20 min; and, additionally, there were on-ground preparations.DISCUSSION:
Only with adequate isolation and protective measures was it possible to air evacuate the potentially contaminated passengers in the initial phase of the pandemic. Specific protective equipment (Personal Protective Equipment – PPE) is mandatory for missions in which the properties of
the potentially contagious biological agent are not fully known, as was the case. Due to the risk of contamination of passengers and the likely evolution of the transport into an aeromedical evacuation, protocols stating the minimum safety conditions for this kind of patient transport must
be followed, with consideration for the patient as well as the crew.Gomes ED, Ronconi MABR, Santos MB, Júnior PP, Franco AZP, Haberland DF, Borges LL. Air evacuation of citizens during the COVID-19 epidemic. Aerosp Med Hum Perform 2022; 93(2):94–98.
Antenatal and perinatal factors associated with newborn behavior: A prospective cohort study
Authors: Tsekoura Effrosine , Chrelia Kleopatra , Pouliakis Abraham , Attilakos Achilleas , Matsota Paraskevi
Published: February 2022

The idea that the newborn is an uncharted and therefore pliable organism, which can be formed according to the will of its parents, has long been rejected, especially after the existence of rules of behavior not only in full-term but also in marginally premature newborns, which are affected by various both prenatal and perinatal factors. The ability of newborns to determine the rules of their behavior according to the stimuli they receive from internal and external factors, has been the subject of many years of research and has led pediatricians and other health professionals to develop a model for grading these newborn abilities. Thus, the Neonatal Behavioral Assessment Scale (NBAS) was created, and it has been used by researchers for more than 40 years. It is a research tool with wide application, as many of the points it addresses, can be integrated into other means of assessing the newborn’s abilities. This scale also has an ever-evolving application as a clinical tool in parental assessment.
Successful management of cervical ectopic pregnancy following invitro fertilisation
Authors: Ugwu Aloy Okechukwu , Makwe Christian Chigozie , Omisakin Sunday Isaac , Ani-ugwu Nneoma Kwemtochukwu , Augustine Egba , Ojiefoh Lulu Gethrude , Okafor Ifunanya Tobechukwu
Published: February 2022

We report a case of a 45-year-old woman with successful management of cervical ectopic pregnancy using ultrasound guided suction evacuation and balloon tamponade. The case report owes its significance to the high morbidity and mortality associated with this form of ectopic pregnancy in our environment, because of misdiagnosis and late presentation.