bluuebunny/crossref_metadata_2025 huggingface dataset:
Construction and Application of a Human-Computer Collaborative Multimodal Practice Teaching Model for Preschool Education
Authors: Tuo Meimei , Long Baoxin
Published: June 2022

This paper adopts the multimodal approach of human-computer collaboration to conduct an in-depth study and analysis of the practical teaching model of preschool education, and applies the designed model to the actual teaching process. The application of multimodal theory to preschool teaching is chosen to theoretically help expand the research scope of multimodal theory and enrich the research of preschool teaching, and practically help break through the previous single-modal teaching model, further enrich the theoretical guidance of preschool teaching, and improve the quality of preschool classroom teaching. Then, from the perspective of human-machine synergy, this paper analyzes the advantages of artificial intelligence technology and teachers in the English classroom, puts forward the new roles of teachers and learners in the human-computer cooperation teaching environment, and discusses the significance and value of applying the four main modules of human-computer cooperation teaching, human-computer gesture mapping and human-computer cooperation manipulator control in the preschool classroom. According to the physical structure of hand joints, the human hand joint angles are obtained through the inverse kinematic solution, and the human hand joint angles correspond to the dexterous manipulator one by one so that the dexterous manipulator can be controlled to imitate the human hand to complete flexible gesture movements and realize the vision-based collaborative human-machine control of the dexterous manipulator. Combined with Gagne’s nine teaching events, a model of the English teaching process based on human-computer collaboration was constructed. Based on this model, the “EasyDotWise English Teaching System” was designed to combine the basic lesson types of preschool classroom teaching and the secondary objectives of the English curriculum standards, including “reading text–reading aloud evaluation,” “playing speech–sound recognition,” and “presenting text–selection.” We designed and implemented three types of teaching activities: “reading text–reading aloud assessment,” “playing phonetic sounds–sound identification,” and “presenting text–comprehension selection.”
Gallbladder Agenesis without Additional Biliary Tracts Abnormality
Authors: Meshkati Yazd Seyed Mostafa , Bayati Hamidreza , Nabavizadeh Sara Sadat , Shahriarirad Reza
Published: June 2022

Background. Gallbladder agenesis (GA) is a very uncommon disorder of the biliary system. Diagnosis of GA can be difficult and may result in unnecessary procedures. In this case report, we will discuss our experience with an intraoperative accidental diagnosis of GA in a middle-aged woman that was effectively treated. Case Presentation. A 46-year-old woman presented with abdominal pain, nausea, vomiting, and intolerance to meals. Laparoscopic surgery was conducted based on sonographic imaging and a preliminary diagnosis of chronic cholecystitis. No gallbladder was seen during laparoscopy, and the patient was diagnosed as a case of GA. The laparoscopy was terminated, and the patient was referred for magnetic resonance cholangiopancreatography (MRCP) to confirm the diagnosis. Finally, endoscopic retrograde cholangiopancreatography (ERCP) and sphincterotomy were performed to alleviate symptoms. After one year of follow-up, the patient’s overall condition is satisfactory and symptom-free. Conclusion. Our case exemplifies this common blunder. Therefore, we are reporting a case of GA discovered intraoperatively to increase surgeons’ awareness and preparedness for this possible differential diagnosis and minimize unnecessary operational intervention.
Construction of Mathematical Model of Enterprise Marketing Economic Analysis Based on Neutral Analytic Hierarchy Process
Authors: Zhang Xin , Zhang Haoyu
Published: June 2022

With the gradual opening of the market, the overall development of Chinese enterprises is “rapid development, gradual improvement of industry status, and promising prospects.” Not only the development of Chinese local enterprises is getting better and better, but also a large number of foreign-funded enterprises are pouring into the domestic market, and the competition pressure on domestic enterprises is increasing. The purpose of this study is to study the effect of neutral AHP on the establishment of the mathematical model of enterprise marketing economic analysis and to use the method of structural judgment matrix and hierarchical structural model to put forward a concrete practical analysis of enterprise marketing cost and business performance. The experimental results of this study show that the establishment of an enterprise marketing economic mathematical model based on AHP can help group companies maintain an annual revenue growth rate of more than 5.8%, while the annual revenue economic growth rate is less than 5% for companies that establish a mathematical model.
The Impact of Mixed-Ownership Reform on Innovation Performance of Manufacturing Companies: Evidence from China
Authors: Xia Wenlei , Chen Xiaofang , Wang Guangming
Published: June 2022

Exploring the impact of a new round of mixed-ownership reform on enterprise development has far-reaching implications for the future development of mixed-ownership reform and the improvement of internal and external corporate governance of the enterprise. This study makes a comprehensive analysis of the relationship between mixed-ownership reform and innovation performance using a combination of empirical testing and theoretical analysis. In terms of theoretical analysis, this study summarizes research on mixed-ownership reform and innovation performance, while also integrating the theoretical basis of the development and institutional background of China’s current mixed-ownership reform, and investigating the impact of mixed-ownership reform on innovation performance. A-share list of manufacturing companies from 2015 to 2018 is selected as the research object, and K-nearest neighbor matching, multiple regression model, and propensity score matching are used to test the effect of mixed-ownership reform on innovation performance. By comparing the changes in the innovation performance level of state-owned enterprises (SOEs) before and after the mixed-ownership reform, this study proposes that the SOEs will not only enhance the competitiveness among manufacturing companies but also will have a positive impact on the high-quality development of the entire society and industrial transformation and upgrading.
Massive MIMO Wireless Solutions in Backhaul for the 5G Networks
Authors: Biradar Arun , Murthy Nimmagadda Sathyanarayana , Awasthi Parul , Srivastava Ajeet Kumar , Akram Patan Saleem , Lakshminarayana M. , Abidin Shafiqul , Vadi Vikas Rao , Sisay Asefa
Published: June 2022

In general, the MIMO technology is used to transfer data from a protocol such as Wi-Fi in 5G networks. This is due to the increased bandwidth and capacity. The 802.11n protocol, which, using the technology described in it, allows you to reach speeds of up to 350 megabits/second. The quality of data transmission has improved even in areas where the reception signal is low. An external access point with a MIMO antenna is a well-known one. The WiMAX network can now transmit information at speeds of up to 40 megabits/second, using MIMO. It uses MIMO technology up to

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. Thanks to this, a higher transfer rate is achieved—over 35 megabits/second. In addition, reliable and high quality connection of the best quality is guaranteed. In this paper, we continue to work and enhance technical configurations of MIMO in 5G networks. The proposed model will improve spectrum performance, improve network capability, and speed up data rates. In a saturation point, the proposed method achieves that the signal to noise interference ratio is just 42.4%, the receiver signal strength is 92.94%, the downstream traffic is 48.76%, the upstream traffic is 45.62%, the bandwidth utilization is 97.43%, the speed is 95.79%, the connectivity between the access point is 90.6%, and the network security is 96.42%.
Application Effect of Motion Capture Technology in Basketball Resistance Training and Shooting Hit Rate in Immersive Virtual Reality Environment
Authors: Wei Wenting , Qin Ziqi , Yan Bihong , Wang Qiulin
Published: June 2022

With the progress of society, sports have become the mainstream of social development. Strengthening the athletic ability of basketball players can effectively improve their shooting percentage. Firstly, virtual reality (VR) technology and motion capture technology are summarized. Secondly, the resistance training and shooting training of basketball players are analyzed and explained. Finally, the algorithm of motion capture technology is designed to capture and optimize the movements of athletes. In addition, a comprehensive evaluation of the shooting percentage of basketball players is carried out. The results show that the motion capture technology proposed here effectively captures the shooting action of basketball players, and the shooting percentage of players is promoted through resistance training. Among all athletes, the highest shooting percentage improvement is around 14% and the lowest is around 4%. In all groups, athletes of different heights have the largest difference in the improvement of shooting percentage. Therefore, this work plays an important role in improving the shooting rate of basketball players through VR technology. It provides technical support for improving the shooting percentage of basketball players and contributes to the progress of athletes’ comprehensive athletic ability.
Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway
Authors: Xie Wenpeng , Chang Wenjie , Wang Xiaole , Liu Fei , Wang Xu , Yuan Daotong , Zhang Yongkui
Published: June 2022

Allicin, an organic sulfur compound extracted from the bulb of Allium sativum, can potentially prevent various tumors. Our previous study found that allicin can effectively suppress the proliferation of osteosarcoma cells. However, the molecular mechanisms have not been illustrated. In this study, Saos-2 and U2OS osteosarcoma cells were used to investigate the underlying mechanisms. A series of experiments were carried out to authenticate the anticancer property of allicin. Knockdown of lncRNA MALAT1 inhibited the proliferation, invasion and migration and promoted apoptosis of osteosarcoma cells. Knockdown of miR-376a increased the proliferation, invasion, and migration and dropped apoptosis of osteosarcoma cells. Furthermore, knockdown of miR-376a reversed the influences of MALAT1 silencing in osteosarcoma cells. Based on our data, MALAT1 could downregulate the expression of miR-376a, subsequently accelerating osteosarcoma. Moreover, oxidative stress and autophagy were identified as the potential key pathway of allicin. Allicin inhibited osteosarcoma growth and promoted oxidative stress and autophagy via MALATI-miR-376a. We also found that allicin promotes oxidative stress and autophagy to inhibit osteosarcoma growth by inhibiting the Wnt/β-catenin pathway in vivo and in vitro. All data showed that allicin promotes oxidative stress and autophagy of osteosarcoma via the MALATI-miR-376a-Wnt/β-catenin pathway.
Epithelioid Hemangioendothelioma with WWTR1-CAMTA1 Fusion in the Parotid Gland Presenting as Bell’s Palsy
Authors: Kunzelman Landon J. , Agarwal Shweta , Boyd Nathan , Broehm Cory J.
Published: June 2022

Epithelioid hemangioendothelioma is a rare tumor of endothelial differentiation most commonly arising in soft tissue, liver, and lung, following a variable clinical course. Most cases are characterized by a t(1;3)(p36;q23-25) resulting in WWTR1-CAMTA1 fusion. Only five epithelioid hemangioendothelioma have been previously reported arising in the salivary glands. None have presented as Bell’s palsy. In the current case, a 37-year-old female presented with a longstanding complaint of pain and fullness in the right preauricular region and progressive episodes of Bell’s palsy and facial nerve weakness. Surgical resection showed a tumor comprised of atypical cells with occasional intracytoplasmic vacuoles in a fibromyxoid stroma. Immunohistochemical stains demonstrated the neoplastic cells expressed ERG, CD31, and CD34, confirming vascular differentiation. Fluorescence in situ hybridization revealed a t(1;3)(p36;q25), confirming a diagnosis of epithelioid hemangioendothelioma. At 12-month follow-up, the patient has no evidence of disease.
Mechanical Properties of Bone Particulate and E-Glass Fiber Reinforced Hybrid Polymer Composite
Authors: Mekonen Sisay Walle , Palani Sivaprakasam , Ravi B. , Atnaw Samson Mekbib , Desta Melaku , Regassa Yohanes
Published: June 2022

The present study is focused on investigating the mechanical properties of hybrid polymer composites. The reinforcement materials are animal bone (ox) particulate and E-glass fiber. The matrix material is epoxy resin. The following combinations are considered for investigation: (a) bone particulate weight percent (20%, 30%, and 40%), (b) E-glass fiber weight percent (20%, 30%, and 40%), and (c) bone particulate (10%, 20%, and 30%) and E-glass fiber (30%, 20%, and 10%) with epoxy resin 60% by weight percent. The test specimens are prepared as per the required ASTM standard for tensile, compressive, and flexural tests. The test results show that maximum tensile and compressive strength observed in 40% of E-glass fiber with 60% of epoxy matrix, correspondingly, is 254.964 MPa and 37.52 MPa. The maximum flexural strength observed in E-glass fiber reinforced composites is 250.43 MPa.
Analysis of the Application Prospect of Computer Image Processing Technology in UI Design
Authors: Ma Guofeng , Yang Junhong
Published: June 2022

In order to improve the interface experience effect of the mobile terminal software, this paper improves the UI design by combining computer image processing technology and improves the diffusion algorithm for images by improving the diffusion model, improving the diffusion coefficient and adaptively selecting the diffusion threshold. Moreover, this paper has carried out deep research on coordinate transformation and image interpolation and stored the result of coordinate transformation in the coordinate transformation table and weight table. In addition, this paper proposes an improved digital scan conversion method based on a lookup table and constructs an improved UI design system model. Through the analysis of experimental data, it can be seen that the application effect of computer image processing technology in UI design is very good, and it can effectively promote the improvement of UI design technology.
Tennis Technology Recognition and Training Attitude Analysis Based on Artificial Intelligence Sensor
Authors: Li Ke
Published: June 2022

In order to solve the problem of traditional tennis serving technique teaching, subjective, and experience-based teaching methods, the author proposes a method to extract tennis training movements based on artificial intelligence sensor video analysis. This method requires the use of ordinary cameras and computer technology; video analysis technology is used to guide tennis teaching and training. The result obtained is as follows: in the experimental group and the control group, at the end of the teaching stage, the movement characteristics of each link of the body are quite different, which can reach 15%-20%; when the experimental group and the control group did the “scratching back” movement during the teaching period, at the end of teaching, the students in the experimental group were close to high-level tennis players in their movement skills, and the movement gap was only about 5%. It is proved that the method proposed by the author provides an objective and scientific basis for measuring the referee’s penalty level. In the grass-roots tennis teaching and training, it has important value and significance and has a great promotion prospect.
Performance Appraisal Model for Optimizing Teacher Incentive and Constraint Mechanisms by Random Matrix
Authors: Fan Zhongtao , Liu Jun , Yang Yifan
Published: June 2022

At present, colleges and universities attach great importance to the assessment of teachers, strengthen the assessment of college teachers, and create a team of teachers with high quality, professionalism, and vitality, which can not only fully develop and allocate human resources in colleges and universities, but also promote colleges and universities. The reform of the personnel system will continuously optimize the proportion and structural allocation of teachers’ resources in colleges and universities, improve the quality and efficiency of running schools, enhance the competitiveness and attractiveness of schools, and better achieve the school’s school-running goals. In order to obtain higher signal reconstruction accuracy and satisfy random matrix with a relatively small compression ratio, this paper combines QR decomposition, which is used to increase the column independence of random matrix, and gradient descent method, which can reduce the cross-correlation between random matrix and sparse matrix. Based on the actual situation of a certain university, this paper studies and designs a set of perfect and reasonable teacher performance appraisal system that meets the requirements of the college, analyzes and researches the current situation of teacher performance appraisal in the college, and finds out the problem. Combining the advanced concept of being good at performance appraisal with the actual situation of the college, it analyzes the problems in the teacher performance appraisal system, summarizes the reasons for the formation of the problem, further redesigns the teacher performance appraisal index system, and gives the relevant implementation of the system. The basic characteristics presented in the organization of colleges and universities will not change. With the continuous adjustment of the organization of colleges and universities, the goals of colleges and universities are also being adjusted. Colleges and universities should continuously improve the performance appraisal system of teachers to make the goals of teachers consistent with the development goals of colleges and universities, so as to continuously improve the basic quality and realization of college teachers.
Green Fuzzy Tourist Trip Design Problem
Authors: Ruiz-Meza José , Brito Julio , Montoya-Torres Jairo R. , Castro-Vergara Ana
Published: June 2022

The shift from mass tourism to more personalized travel denotes great importance in the construction of tourist itineraries. Given the negative impacts of transport and tourism on the environment, sustainability criteria play an important role. The Tourist Trip Design Problem is related to the design of itineraries for tourists. Planning is complex in tourist regions of developing countries where the information associated with tourist activities is difficult to access, vague, and incomplete. With this information, tourists must plan their trip, and the conditions and limitations they establish for it are flexible and imprecise. Fuzzy optimization can address problems with this type of information and constraints. Therefore, in this paper, an analysis of the tourism supply chain is carried out, taking as a case study the Department of Sucre on Colombia's Caribbean coast. A Multiconstraint Multimodal Team Orienteering Problem with Time Windows and fuzzy constraints is developed to model the tourism trip design problem that maximizes profit and minimizes CO2 emissions. The model is tested using datasets from the literature and the real world. The results demonstrate consistency with the fuzzy approach and generate a set of low-emission solutions.
Iatrogenic Femoral Arteriovenous Fistula with Pseudoaneurysm Associated with Worsening Heart Failure Years after Percutaneous Impella Placement
Authors: Wang Andy Y. , Al Jabri Ali , Jewell Edward R. , Jellison Angela L.
Published: June 2022

Iatrogenic arteriovenous fistulas (AVFs) and pseudoaneurysms (PSAs) are rare complications that may develop years after vascular access, and high-volume flow through these AVFs have been hypothesized to contribute to chronic heart failure. Formation of an AVF or PSA following Impella placement has rarely been described in the literature. Here, we describe a patient who had percutaneous placement of an Impella ventricular assist device through his right groin three years prior, now presenting with worsening heart failure and symptoms of volume overload. He was discovered to have a new, high-flow common femoral artery to femoral vein AVF with an associated PSA. The AVF and associated PSA were resected and repaired. This case study highlights a rare access-site complication from percutaneous Impella placement associated with worsening heart failure, strategies for preventing this complication during peripheral access, and the need to consider this differential in such a patient with a history of peripheral access who has an unexplained worsening of heart failure.
APY0201 Represses Tumor Growth through Inhibiting Autophagy in Gastric Cancer Cells
Authors: Li Huan , Jin Xinghan , Zhang Shiwei , Li Bo , Zeng Leli , He Yulong , Zhang Changhua
Published: June 2022

Gastric cancer (GC) is one of the most common cancers globally. There are currently few effective chemotherapeutic drugs available for GC patients. The inhibitors of phosphatidylinositol kinase containing an FYVE finger structure (PIKfyve) have shown significant anticancer effects in several types of cancers, but their effectiveness in GC remains unknown. In this study, we investigate the effect of APY0201, an inhibitor of PIKfyve, on GC tumor growth and its mechanism of action. It was found that APY0201 inhibited GC cell proliferation in in vitro GC cell model, organoid model, and in vivo xenograft tumor model. Through analyzing cell autophagy, we found that APY0201 might block autophagic flux by impairing lysosome degradation function of GC cells, inducing the accumulation of autophagosomes, thus causing the inhibition of GC cell proliferation. We also found that APY0201 induced G1/S phase arrest in GC cells. Importantly, APY0201 was also effective in inducing repression of autophagy and cell cycle arrest in the mouse tumor xenograft. Our results suggest that APY0201 could be a new promising therapeutic option for GC.
Effect of Demand Response Programs on Industrial Specific Energy Consumption: Study at Three Cement Plants
Authors: Siahchehre Kholerdi Somayeh , Ghasemi-Marzbali Ali
Published: June 2022

Demand-side management (DSM) is the modification of consumer utilization manner for energy through various methods to smooth their power consumption curve and increase their energy efficiency. Although the DSM improves the electricity grid stability and protects the environment, it allows customers to reduce their costs. The available literature classifies DSM into two different areas: (i) energy efficiency (EE) and (ii) demand response (DR). In other words, cement plants are the largest customers of electricity, so the implementation of DSM programs in these heavy industries is very important for electricity companies. Past studies have often examined the impact of DR programs in cement factories on solving peak problems and changing load profiles but have not studied the effects of DR implementation on the energy efficiency index in the short and long term in these industries. In this paper, while examining the effect of implementing three types of common DR programs in smart grids including demand bidding (DB), ancillary services (A/S), and time of use (TOU) on the load profile of cement plants, based on the mathematical model of the load and the real data of the case study, it is shown that the implementation of the TOU program has created the highest energy efficiency by reducing specific energy consumption (SEC) in cement plants.
Soil and Water Conservation Nexus Agricultural Productivity in Ethiopia
Authors: Abiye Wudu
Published: June 2022

Soil and water conservation practices contribute to long-term agricultural sustainability and sustainable agriculture. This review examines the primary agronomic practices and their role in soil and water conservation. The review revealed that Ethiopia's significant agronomic soil and water conservation practices are strip cropping, mixed cropping, intercropping, fallowing, mulching, contour plowing, crop rotation, preservation of tillage, and agroforestry. A significant difference was found between conserved and nonconserved land in terms of soil chemical and physical properties, soil organic matter, total N, available phosphorous (P), bulk density, infiltration rate, and soil texture. The non-conserved land had lower soil organic matter, total N, and infiltration rate with higher bulk density, clay content, and available P. Soil organic matter content positively correlated with infiltration rate and total N, and it negatively correlated with soil bulk density. Cation exchange capacity (CEC) positively correlated with soil pH and available P. The undulating lands were moderately suitable for rain fed agriculture. The plant canopies, litter, and mulching intercept rain by decreasing the amount, intensity, and spatial distribution of the precipitation reaching the soil surface, protecting the soil surface from the direct impact of raindrops that can cause splash and sheet erosion. In soil and water conservation, this practice is higher than others because crops and leguminous woody perennials improve and enrich soil conditions through atmospheric nitrogen fixation, organic matter through litterfall and dead and decaying roots, nutrient cycles, modification of soil porosity, and contribution to infiltration rates. It also relieves and maintains salinity, alkalinity, acid, and water retention problems. To increase the water table and increase soil moisture, water conservation is based on trapping as much of this water as possible and storing it on the surface (intanks) or allowing it to sink into the soil. Even where storage pans are dug, they are small and cannot keep the premises afloat when the drought lasts for days, as they have done recently. It is strongly recommended that the productivity of soil and water conservation measures is promoted through an integrated approach in which farmers are intensively involved in every implementation stage.
Investigations on the Changes of Serum Proteins in Rabbits after Trimeresurus stejnegeri Venom Injection via Mass Spectrometry-Based Proteomics
Authors: Wang Shijun , Yang Weilian , Shi Wanling , Chen Fuwei , Shen Fanghua , Zhang Meiji , Su Qiuxiang , Shi Chao , Yu Qinyao , Chen Tao
Published: June 2022

Purpose. There are few studies on protein phosphorylation in the process of snake poisoning. The purpose of this study was to investigate the toxic mechanism of Trimeresurus stejnegeri at the protein level by determining the differential expression of phosphorylated proteins in rabbits after poisoning using proteomics. Methods. The Trimeresurus stejnegeri venom model in rabbits was established by intramuscular injection of 20 mg/kg venom. The serum was collected and the differential expression of phosphorylated proteins in the serum was determined by the iTRAQ technology, TiO2 enriched phosphorylated peptides, and the mass spectrometry analysis. The functional analysis was conducted using ClueGO software and the related mechanism was evaluated by the network analysis of biological interaction. The expression level of related proteins was determined by the Western blotting assay. Results. Compared to the control group, 77 differentially expressed proteins were observed in the model group. These proteins were closely associated with the complement and agglomerate cascade signaling pathways, the HIF signaling pathway, the pentose phosphate pathway, and the cholesterol metabolism signaling pathway. According to the results of network analysis, TF and SCL16A1 were determined as the core proteins, which were identified by the Western blotting assay. Conclusion. The present study provided valuable phosphorylation signal transduction resources for investigating the toxic mechanism and the therapies for Trimeresurus stejnegeri poisoning.
An Intelligent Prediction for Sports Industry Scale Based on Time Series Algorithm and Deep Learning
Authors: Liang Hui
Published: June 2022

Aiming at some existing issues in the sports industry, the existing model is optimized by deep learning and time series theory based on the relevant algorithm, and the scale of the sports industry is analyzed and predicted by the model. The results show the following: (1) Based on the single-step prediction of time series, MNTS structural algorithm can be used to describe and study the sports industry scale with the single factor, and the correlation fitting degree is high. (2) Curves of different evaluation methods can include parts linear stage and nonlinear stage according to the magnitude of change. (3) Seen from the optimization model in this paper, the proposed method can describe both global and local trends of data. (4) It can be seen from the prediction curve that the overall state of fluctuation indicates that time will have a great impact on the relevant scale of the sports industry. Compared with single-step prediction, the accuracy of multistep prediction is higher, and the multistep prediction model based on time series can well characterize and predict the scale of the sports industry. By using the relevant time algorithm, the sports industry scale can be predicted and analyzed so as to provide theoretical support for the formulation and implementation of relevant policies.
Numerical Simulation of Fine Blanking Die Wear and Die Performance Analysis
Authors: Li Yamin , Zhao Yali , Hao Yongxing
Published: June 2022

In order to study the die wear law of rotary fine blanking helical cylindrical gear, a three-dimensional rigid plastic finite element model of rotary fine blanking helical cylindrical gear is established on the Deform-3D software platform. Based on the Archard wear model, this paper analyzes the die wear in the fine blanking process, obtains the wear distribution of each point on the working surface of the die, determines the maximum wear area, and makes a comparative analysis with the fine blanking die wear of spur gear. Through the single factor variable method, this paper studies the effects of reverse jacking force, blank holder force, blanking speed, punch and die clearance, die fillet radius, and die initial hardness on die wear. The test results show that when the punch reduction is the same, the wear of the female die of fine blanking helical cylindrical gear is greater than that of fine blanking spur cylindrical gear. When the counter jacking force increases from 100 kN to 200 kN, the maximum wear of the die gradually increases from 6.91 × 10–6 mm to 9.38 × 10–6 mm; when the blank holder force increases to 3/4 of the blanking force, the die wear decreases with the increase of blank holder force; it is ideal when the blanking clearance is 0.5% t (0.02 mm). Conclusion. The wear model can accurately predict the relationship between main process parameters and wear in the process of rotary fine blanking, and the measures to reduce die wear are put forward from the aspect of process design.
Prospective Associations of Hemoglobin A1c and c-peptide with Risk of Diabetes-related Cancers in the Cancer Prevention Study-II Nutrition Cohort
Authors: Campbell Peter T. , Newton Christina C. , Jacobs Eric J. , McCullough Marjorie L. , Wang Ying , Rees-Punia Erika , Guinter Mark A. , Murphy Neil , Koshiol Jill , Dehal Ahmed N. , Rohan Thomas , Strickler Howard , Petrick Jessica , Gunter Marc , Zhang Xuehong , McGlynn Katherine A. , Pollak Michael , Patel Alpa V. , Gapstur Susan M.
Published: June 2022

Self-reported type 2 diabetes mellitus (T2DM) is a risk factor for many cancers, suggesting its pathology relates to carcinogenesis. We conducted a case-cohort study to examine associations of hemoglobin A1c (HbA1c) and c-peptide with cancers associated with self-reported T2DM. This study was drawn from a prospective cohort of 32,383 women and men who provided blood specimens at baseline: c-peptide and HbA1c were assessed in 3,000 randomly selected participants who were cancer-free-at-baseline and an additional 2,281 participants who were cancer-free-at-baseline and subsequently diagnosed with incident colorectal, liver, pancreatic, female breast, endometrial, ovarian, bladder, or kidney cancers. Weighted Cox regression models estimated HRs and 95% confidence intervals (CI), adjusted for covariates. c-peptide was associated with higher risk of liver cancer [per SD HR: 1.80; 95% CI: 1.32–2.46]. HbA1c was associated with higher risk of pancreatic cancer (per SD HR: 1.21; 95% CI: 1.05–1.40) and with some suggestion of higher risks for all-cancers-of-interest (per SD HR: 1.05; 95% CI: 0.99–1.11) and colorectal (per SD HR: 1.09; 95% CI: 0.98–1.20), ovarian (per SD HR: 1.18; 95% CI: 0.96–1.45) and bladder (per SD HR: 1.08; 95% CI: 0.96–1.21) cancers. Compared with no self-reported T2DM and HbA1c < 6.5% (reference group), self-reported T2DM and HbA1c < 6.5% (i.e., T2DM in good glycemic control) was not associated with risk of colorectal cancer, whereas it was associated with higher risks of all-cancers-of-interest combined (HR: 1.28; 95% CI: 1.01–1.62), especially for breast and endometrial cancers. Additional large, prospective studies are needed to further explore the roles of hyperglycemia, hyperinsulinemia, and related metabolic traits with T2DM-associated cancers to better understand the mechanisms underlying the self-reported T2DM-cancer association and to identify persons at higher cancer risk.

Significance:

The results from this study suggest that HbA1c and c-peptide, markers of hyperglycemia and hyperinsulinemia respectively, are associated with certain cancers, though people with diabetes may be at increased risk of these cancers, perhaps other than colorectal, even when their glucose is well controlled.
Vaccine Toes Are the New COVID Toes
Authors: Hodge Bonnie , Daniel C. Ralph , Elewski Boni Elizabeth
Published: June 2022

Introduction: Pernio-like lesions were reported as dermatologic manifestations of COVID-19 as early as May of 2020. Since mRNA COVID-19 vaccines were introduced in December 2020, 9 reports of vaccine-associated pernio-like lesions have been presented in the medical literature. Case Presentation: A male in his 60s developed pernio-like lesions on the bilateral toes approximately 1 week after receiving the second dose of the Pfizer-BioNTech COVID-19 mRNA vaccine. His symptoms resolved in 6 weeks. Conclusion: The rising number of reports of pernio-like lesions associated with COVID-19 vaccination underlines the importance of the pathophysiological state of the vaccinated patient and how it relates to dermatological manifestations. Pernio-like lesions are thought to represent a robust host immune antiviral response related to production of interferon-1 in the setting of primary infection; incidences occurring after vaccination further support this theory. Unfortunately, media-generated reports of such reactions have the potential to inflame distrust and fear of the vaccine among the general public. Given the previous media interest in reporting pernio-like lesions with primary COVID-19 infection, it is reasonable to expect overrepresentation of pernio-like lesions with vaccination. There appears to be a general increase in patient distrust of evidence-based medicine and thus “COVID toes” represent an important intersection at which the clinician can capture the patient’s trust by providing education and counseling.
Cerebral Venous Thrombosis due to Cryptococcus in a Multiple Sclerosis Patient on Fingolimod
Authors: Kammeyer Joel A. , Lehmann Nicole M.
Published: June 2022

Fingolimod is a disease-modifying treatment utilized in the treatment of relapsing-remitting multiple sclerosis. Fingolimod has been associated with an increased risk in herpes simplex and varicella infection in clinical trials. We report a case of cerebral venous thrombosis secondary to cryptococcus in a patient receiving fingolimod. A 61-year-old male with multiple sclerosis treated with fingolimod presented with a 2-week history of headache, chills, and night sweats. An MRI of the brain revealed a left transverse and sigmoid sinus thrombosis. Two blood cultures revealed Cryptococcus neoformans; a serum cryptococcal antigen was also positive. HIV testing was negative. A lumbar puncture was deferred as the patient was placed on heparin and, subsequently, warfarin for the cerebral venous thrombosis. The patient received antifungal therapy for 14 days with liposomal amphotericin B and flucytosine, followed by oral fluconazole for 8 weeks. He was subsequently readmitted 60 days later with bilateral papilledema; his anticoagulation was reversed, and a lumbar puncture revealed a negative cryptococcal antigen and an intracranial pressure of 20. A repeat MRI revealed worsening superior sagittal sinus thrombosis, thought to be the cause of the papilledema; his anticoagulation was reinitiated. He received a brief course of intravenous methylprednisolone, but as his multiple sclerosis was well-controlled, further therapy was deferred. His symptoms had resolved at a 3-month follow-up appointment. This is the first report of a multiple sclerosis patient treated with fingolimod to develop cerebral venous thrombosis secondary to cryptococcal fungemia. The risks of opportunistic infections should be considered in patients managed with fingolimod.
Epidemiology and estimated economic impact of musculoskeletal injuries in polytrauma patients in a level one trauma centre in Singapore
Authors: Tan Joel Yong Hao , Tan Jiong Hao , Tan Si Heng Sharon , Shen Liang , Loo Lynette Mee-Ann , Iau Philip , Murphy Diarmuid Paul , O’Neill Gavin Kane
Published: June 2022

Introduction:

Musculoskeletal injuries are the most common reason for surgical intervention in polytrauma patients.

Methods:

This is a retrospective cohort study of 560 polytrauma patients (injury severity score [ISS] >17) who suffered musculoskeletal injuries (ISS >2) from 2011 to 2015 in National University Hospital, Singapore.

Results:

560 patients (444 [79.3%] male and 116 [20.7%] female) were identified. The mean age was 44 (range 3–90) years, with 45.4% aged 21–40 years. 39.3% of the patients were foreign migrant workers. Motorcyclists were involved in 63% of road traffic accidents. The mean length of hospital stay was 18.8 (range 0–273) days and the mean duration of intensive care unit (ICU) stay was 5.7 (range 0–253) days. Patient mortality rate was 19.8%. A Glasgow Coma Scale (GCS) score <12 and need for blood transfusion were predictive of patient mortality (p < 0.05); lower limb injuries, road traffic accidents, GCS score <8 and need for transfusion were predictive of extended hospital stay (p < 0.05); and reduced GCS score, need for blood transfusion and upper limb musculoskeletal injuries were predictive of extended ICU stay. Inpatient costs were significantly higher for foreign workers and greatly exceeded the minimum insurance coverage currently required.

Conclusion:

Musculoskeletal injuries in polytrauma remain a significant cause of morbidity and mortality, and occur predominantly in economically productive male patients injured in road traffic accidents and falls from height. Increasing insurance coverage for foreign workers in high-risk jobs should be evaluated.
Jesus, the Holder of the Seven Stars in His Right Hand
Authors: Lee Sanghwan
Published: June 2022

In Rev 1:16a, Jesus is portrayed as holding the seven stars in his right hand. The immediate context interprets this imagery as Jesus’s exercising his sovereignty over the seven angels of the seven churches (v. 20). This article suggests that a secondary interpretation is possible in light of numismatic evidence and the larger context of Revelation. According to this reading, the depiction of Jesus in Rev 1:16a functions as a literary device that subverts the message embedded in the Divvs Caesar coin types—a message that promotes the imperial power. By portraying Jesus as the holder of the seven stars in his right hand, the author of Revelation places Jesus far above the imperial power, claiming that Jesus is the ruler par excellence whose sovereignty extends to both the terrestrial and celestial realms.
The Construction and Contents of the Beatty-Michigan Pauline Epistles Codex (𝔓⁴⁶)
Authors: Nongbri Brent
Published: June 2022

The surviving portion of the papyrus codex of the letters of Paul split between the Chester Beatty Library and the University of Michigan (𝔓⁴⁶) consists of a well preserved but damaged single quire containing parts of nine of Paul’s letters. Because the pages of the codex are numbered, scholars have believed that it is possible to reconstruct the original size of the quire, which turns out to be too small for the traditional Pauline corpus of fourteen letters. Many scholars have taken this to mean that the codex did not contain the Pastoral letters (1–2 Timothy and Titus). Jeremy Duff has argued that the copyist increased the number of letters per page in the second half of the codex and intended to add extra leaves in order to produce a codex with all of the fourteen letters found in the majority of undamaged Greek manuscripts of Paul’s letters. While Duff’s hypothesis has been critically engaged on other grounds, this article assesses Duff’s proposed ancient comparanda for the addition of extra folia to the end of a single-quire codex and revisits the problem of the contents of this codex in light of the construction techniques of better preserved single-quire codices.
Regimes and Transitions in the Basal Melting of Antarctic Ice Shelves
Authors: Rosevear Madelaine G. , Gayen Bishakhdatta , Galton-Fenzi Benjamin K.
Published: June 2022

The Antarctic Ice Sheet is losing mass as a result of increased ocean-driven melting of its fringing ice shelves. Efforts to represent the effects of basal melting in sea level projections are undermined by poor understanding of the turbulent ice shelf–ocean boundary layer (ISOBL), a meters-thick layer of ocean that regulates heat and salt transfer between the ocean and ice. To address this shortcoming, we perform large-eddy simulations of the ISOBL formed by a steady, geostrophic flow beneath horizontal ice. We investigate melting and ISOBL structure and properties over a range of free-stream velocities and ocean temperatures. We find that the melting response to changes in thermal and current forcing is highly nonlinear due to the effects of meltwater on ISOBL turbulence. Three distinct ISOBL regimes emerge depending on the relative strength of current shear and buoyancy forcing: “well-mixed,” “stratified,” or “diffusive-convective.” We present expressions for mixing-layer depth for each regime and show that the transitions between regimes can be predicted with simple nondimensional parameters. We use these results to develop a novel regime diagram for the ISOBL which provides insight into the varied melting responses expected around Antarctica and highlights the need to include stratified and diffusive-convective dynamics in future basal melting parameterizations. We emphasize that melting in the diffusive-convective regime is time dependent and is therefore inherently difficult to parameterize.

Significance Statement

The purpose of this study is to investigate the processes that control ocean-driven melting of Antarctic ice shelves (100–1000-m-thick floating extensions of the Antarctic ice sheet). Currently, these processes are poorly understood due to the difficulty of accessing the ocean beneath ice shelves. Using an ocean model, we determine the melting response to different ocean conditions, including feedbacks whereby cold, fresh meltwater can enhance or suppress turbulent eddies beneath the ice, depending on the ocean state. Our results point the way to improvements in the representation of ocean-driven melting in ocean/climate models, which will allow more accurate predictions of future climate and sea level.
Smartphone Use for Patient Photography by Plastic Surgery Trainees
Authors: Veith Jacob , King Brody W. , Moss Whitney , Luo Jessica , Dunklebarger Mitchell , Garlick Jared , Crombie Courtney
Published: June 2022

Medical photography has become essential to patient care, trainee education, and research in highly visual specialties such as plastic surgery. As smartphone technology advances, plastic surgeons and trainees are using their personal smartphones to take medical photographs prompting ethical and legal concerns about patient consent and privacy. This study aims to determine the prevalence of personal smartphone use for patient photography among plastic surgery trainees, evaluate encryption practices, and establish understanding of current guidelines. Through a survey of 71 plastic surgery trainees throughout the United States, we show that 99% use their personal cell phone to take medical photographs while only 65% use HIPAA-compliant photo storage applications, and only 49% are aware of standard guidelines. This highlights that personal smartphone use among plastic surgery trainees is ubiquitous and there is a need for additional education and access to HIPAA-compliant photo storage applications.
Expectations in the Communication About Death and Dying: Development and Initial Validation of the End-of-Life Conversations – Expectations Scale
Authors: Bendel Yannik , Pinquart Martin , Schulz-Quach Christian , von Blanckenburg Pia
Published: June 2022

End-of-life (EOL) conversations with relatives or significant others are often avoided. One reason can be negative expectations regarding these conversations. The present study was conducted to develop and initially validate the End-of-Life Conversations – Expectations Scale (EOLC-E). An exploratory factor analysis ( N = 307) resulted in a 20-item version with three distinct dimensions: expected own emotional burden (α = .92), expected other person’s emotional burden (α = .94) and communication self-efficacy (α = .89). The EOLC-E total score correlated significantly with communication apprehension about death ( r = .62), fear of death ( r = .58), death avoidance ( r = .52) as well as readiness for end-of-life conversations ( r = −.38) and occurrence of previous conversations ( r = −.29). Results suggest that the EOLC-E is a reliable and valid instrument to assess death and dying communication expectations. This measure has utility in communication research focusing on optimizing expectations and increasing EOL communication.
Governance, Participation, and Hegemony: Governing Cananea and the Sonora River Region
Authors: Guarneros-Meza Valeria
Published: June 2022

Building upon critical debates on network governance in policy making and complementary debates on corporate social responsibility in Mexican mining, a study of the municipality of Cananea and the Sonora River region of Mexico indicates that the (mis)management of information and implementation of participatory mechanisms produced administrative domination in the relationships between government authorities and the mining corporation. Gramscian understandings of hegemony have limitations when dealing with decentered relations beyond state actors. Therefore, Foucauldian concepts of governmentality are useful to complement understandings of power relations in governance arrangements.

A partir de los debates críticos sobre la gobernanza de redes en la formulación de políticas y debates complementarios sobre la responsabilidad social corporativa en la minería mexicana, un estudio en torno al municipio de Cananea y la región del río Sonora, en territorio mexicano, argumenta que el (mal) manejo de la información y la implementación de mecanismos participativos produjeron dominación administrativa en las relaciones entre las autoridades gubernamentales y la corporación minera. Las interpretaciones gramscianas de la hegemonía se topan con limitantes cuando se trata de relaciones descentradas que van más allá de los actores estatales. Por lo tanto, los conceptos foucaultianos de la gubernamentalidad son útiles para complementar la comprensión de las relaciones de poder en los acuerdos de gobernanza.