bluuebunny/crossref_metadata_2025 huggingface dataset:
Exogenous Application of dsRNA for the Control of Viruses in Cucurbits
Authors: Delgado-Martín Josemaría , Ruiz Leticia , Janssen Dirk , Velasco Leonardo
Published: June 2022

The recurrent emergence of viral diseases in intensive horticultural crops requires alternative control strategies. The topical application of double-stranded RNA (dsRNA) molecules homologous to pathogens has been proposed as a tool for virus control in plants. These dsRNAs induce the silencing mechanism, the RNA interference (RNAi), that degrades homologous dsRNAs. Cucumber green mottle mosaic virus (CGMMV) represents a serious threat to cucurbit crops. Since genetic resistance to the virus is not yet available in commercial varieties, we aimed to control this virus by RNAi. For this purpose, we obtained constructions both for expressing dsRNA in bacteria to treat cucumber plants by topical application and for agroinoculation in experiments done in the growth chamber. Besides, greenhouse tests were performed in spring and in summer when plants were challenged with the virus, and differences in several parameters were investigated, including the severity of symptoms, dry weight, total height, virus accumulation, and virus-derived small interfering RNAs (vsiRNAs). Spraying of plants with dsRNA reduced significatively CGMMV symptoms in the plants in growth chamber tests. Agroinfiltration experiments done under identical conditions were also effective in limiting the progress of CGMMV disease. In the greenhouse assay performed in spring, symptoms were significantly reduced in dsRNA-sprayed plants, and the development of the plants improved with respect to non-treated plants. Virus titers and vsiRNAs were clearly reduced in dsRNA-treated plants. The effect of protection of the dsRNA was less evident in the greenhouse assay carried out in the summer. Besides, we investigated the mobility of long (ds)RNA derived from spraying or agroinfiltrated dsRNA and found that it could be detected in local, close distal, and far distal points from the site of application. VsiRNAs were also detected in local and distal points and the differences in accumulation were compared. In parallel, we investigated the capacity of dsRNAs derived from genes of tomato leaf curl New Delhi virus (ToLCNDV), another economically important virus in cucurbits, to limit the disease in zucchini, both by agroinfiltration or by direct spraying, but found no protective effect. In view of the results, the topical application of dsRNAs is postulated as a promising strategy for CGMMV control in the cucumber.
Cultural Entertainment Consumption and Empathy Communication Mechanism
Authors: Zhang Wenming
Published: June 2022

The economic and cultural effects of sports films have attracted close attention from academia as well as the industry. In this paper, two sub-studies were conducted to explore the empathy mechanism performance of the interest-related community in sports films. In Study 1, the film Lead was applied as an example and used network text analysis to analyze the discourse characteristics and structure of its interest-related community to grasp the practice regularities. More specifically, the results in Study 1 show that the theme feature, brand building, technological innovation, and spirit communication are the key factors that affect an individual's empathy for sports films. In Study 2, I conducted a survey to explore the empathy mechanism of sports films in the new age to provide a theoretical reference for the high-quality development of films. The above-mentioned four main factors have positive impacts on empathy: affective empathy and cognitive empathy.
Getting Ahead While Getting Along: Followership as a Key Ingredient for Shared Leadership and Reducing Team Conflict
Authors: Baird Noelle , Benson Alex J.
Published: June 2022

Followership and leadership provide two distinct but complementary sets of behaviors that jointly contribute to positive team dynamics. Yet, followership is rarely measured in shared leadership research. Using a prospective design with a sample of leaderless project teams, we examined the interdependence of leadership and followership and how these leader-follower dynamics relate to relationship conflict at the dyadic and team level. Supporting the reciprocity of leader-follower dynamics, social relations analyses revealed that uniquely rating a teammate higher on effective leadership was associated with being rated higher by that same person on effective followership. Additionally, team members with a reputation as an effective leader also tended to be viewed as an effective follower. As expected, team levels of leadership were tightly linked to team levels of followership. Connecting these results to relationship conflict at the dyadic level, we found that uniquely rating someone as an effective follower or an effective leader would decrease the likelihood of experiencing interpersonal conflict with that person and that having a reputation for effective followership or effective leadership relates negatively to being viewed as a conflict hub within the team. Finally, effective followership was significantly negatively related to team levels of conflict, but we did not find a significant relation between effective leadership and relationship conflict at the team level. Our results highlight that followership is not only a necessary ingredient for high levels of shared leadership to exist within a team, but it underpins more functional team interactions.
Brain Activation During Processing of Depression Emotion in College Students With Premenstrual Syndrome in China: Preliminary Findings
Authors: Gao Mingzhou , An Li , Yu Yanhong , Wang Jieqiong , Hou Yanjiao , Xu Qiuqi , Ren Lvning , Gao Dongmei
Published: June 2022

Background

This study aimed to investigate the neural substrates of processing depression emotion in premenstrual syndrome (PMS) and healthy subjects of college students using blood oxygenation level-dependent functional magnetic resonance imaging (BOLD-fMRI).

Methods

During BOLD-fMRI scanning, 13 PMS patients and 15 healthy controls (HC) performed a picture visual stimulation task during luteal and follicular phases, in which participants and HC were asked to see pictures containing depression and non-depression emotions. Simultaneously, self-rating depression scales (SDS) were employed to evaluate the emotional status of participants.

Results

Compared to HC, right inferior occipital gyrus, right middle occipital gyrus, right lingual gyrus, right fusiform gyrus, right inferior temporal gyrus, cerebelum_crus1_R, cerebelum_6_R, culmen, the cerebellum anterior lobe, tuber, and cerebellar tonsil of PMS patients showed enhanced activation. In contrast, sub-lobar, sub-gyral, extra-nuclear, right orbit part of superior frontal gyrus, right middle temporal gyrus, right orbit part of inferior frontal gyrus, limbic lobe, right insula, bilateral anterior and adjacent cingulate gyrus, bilateral caudate, caudate head, bilateral putamen, and left globus pallidus exhibited decreased activation.

Conclusion

The findings indicate that abnormal functional regulation of brain regions such as occipital lobe and cerebellum leads to abnormal changes in emotional regulation, cognitive ability, and attention distribution in PMS patients, implying significant central pathogenesis.
The Prevalence of Fear of Childbirth and Its Association With Intolerance of Uncertainty and Coping Styles Among Pregnant Chinese Women During the COVID-19 Pandemic
Authors: Han Lingli , Bai Hua , Lun Bing , Li Yanxia , Wang Yingfan , Ni Qingnan
Published: June 2022

Background

Fear of childbirth (FOC) is one of the most common psychological symptoms among pregnant women and significantly relates to cesarean section, anxiety, and depression. However, it is not clear the prevalence and risk factors of FOC among Chinese pregnant women since the outbreak of the COVID-19 pandemic.

Aims

The objective of this study was to examine the associations between coping styles, intolerance of uncertainty, and FOC.

Method

From December 2021 to April 2022, a cross-sectional survey was conducted in two hospitals in China through convenient sampling. The cross-sectional survey was conducted among 969 pregnant women, which included the Childbirth Attitude Questionnaire (CAQ), Intolerance of Uncertainty Scale-12 (IUS-12), and Simplified Coping Style Questionnaire (SCSQ).

Results

The total prevalence of FOC was 67.8%. The percentages of women with mild (a score of 28–39), moderate (40–51), and severe FOC (52–64) were 43.6, 20.2, and 4.0%, respectively. The regression results indicated that primiparas, unplanned pregnancy, few spousal support, intolerance of uncertainty, and negative coping styles were significant risk factors of FOC. Women who adopt positive coping strategies experienced a lower level of childbirth fear.

Conclusion

These findings suggest that cultivating positive coping styles and obtaining sufficient childbirth information may be helpful for mothers' mental health. Regular screening assessment of perinatal psychological symptoms, such as the high level of intolerance of uncertainty and negative coping styles, should be adopted to reduce the risk of fear of childbirth.
Cumulative Family Risk and Cyberbullying Among Chinese Adolescents: The Chain Mediating Role of School Connectedness and Cyber Victimization
Authors: Gan Xiong , Li Hao , Xiang Guo-xing , Lai Xin-hua , Jin Xin , Wang Pin-yi , Zhu Cong-shu
Published: June 2022

Abundant evidence has demonstrated that cumulative family risk is associated with cyberbullying. However, few studies to date have investigated how cumulative family risk links to cyberbullying. To fill in these gaps, the present study examined the mediating role of school connectedness and cyber victimization in the relation between cumulative family risk and cyberbullying. A sample of 1,804 Chinese adolescents was recruited to complete measures of cumulative family risk, cyberbullying, school connectedness, cyber victimization, and demographic variables through convenience sampling. There were 813 boys and 991 girls, aged from 13 to 18, with an average age of 16 years (SD = 1.71). Correlational analyses and SPSS macro PROCESS (Model 6) were used for major data analysis. Results indicated that cumulative family risk was positively associated with cyberbullying, and this link could be mediated by school connectedness and cyber victimization. The present study identifies the potential underlying mechanism by which cumulative family risk is associated with adolescent cyberbullying, which has important implications for theory and prevention.
A Global Perspective of Correlation Between Maternal Copper Levels and Preeclampsia in the 21st Century: A Systematic Review and Meta-Analysis
Authors: Zhong Zixing , Yang Qingmei , Sun Tao , Wang Qianqian
Published: June 2022

Background:

Preeclampsia (PE) is a common multi-system disorder in pregnancy and a major cause of maternal and perinatal morbidity and mortality globally. Copper is a crucial micronutrient for human health.

Methods

A systematic review was performed according to Preferred Reporting Item for Systematic Reviews and Meta-analysis (PRISMA) guidelines to synthesize the best available evidence regarding the correlation between maternal copper levels and PE from women with different geographical and economic backgrounds.

Results

A total of 34 studies containing 2,471 women with PE and 2,888 healthy pregnant controls across 16 countries were included for research. All studies were systematically reviewed and assessed with the Newcastle-Ottawa Scale (NOS), The Agency of Healthcare for Research and Quality (AHRQ) assessment tools according to the study types. Globally, there was no significant difference in maternal serum copper levels between women with PE and control (Mean difference 5.46, 95% CI −9.63, 20.54). Sub-group analysis from geographical and economic perspectives revealed contrasting results. In conclusion, copper is associated with PE, but the levels of copper leading to increased risk of PE varied across regions and economic development.

Conclusions

The deranged maternal copper levels are correlated with risks of PE, but it presents variously across different geographical and economic contexts.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=306536. Identifier: CRD42022306536.
A Survey on Human Cancer Categorization Based on Deep Learning
Authors: Ibrahim Ahmad , Mohamed Hoda K. , Maher Ali , Zhang Baochang
Published: June 2022

In recent years, we have witnessed the fast growth of deep learning, which involves deep neural networks, and the development of the computing capability of computer devices following the advance of graphics processing units (GPUs). Deep learning can prototypically and successfully categorize histopathological images, which involves imaging classification. Various research teams apply deep learning to medical diagnoses, especially cancer diseases. Convolutional neural networks (CNNs) detect the conventional visual features of disease diagnoses, e.g., lung, skin, brain, prostate, and breast cancer. A CNN has a procedure for perfectly investigating medicinal science images. This study assesses the main deep learning concepts relevant to medicinal image investigation and surveys several charities in the field. In addition, it covers the main categories of imaging procedures in medication. The survey comprises the usage of deep learning for object detection, classification, and human cancer categorization. In addition, the most popular cancer types have also been introduced. This article discusses the Vision-Based Deep Learning System among the dissimilar sorts of data mining techniques and networks. It then introduces the most extensively used DL network category, which is convolutional neural networks (CNNs) and investigates how CNN architectures have evolved. Starting with Alex Net and progressing with the Google and VGG networks, finally, a discussion of the revealed challenges and trends for upcoming research is held.
Connecting Scientists Residing Abroad: A Review of Converciencia as a Practice to Engage the Guatemalan Scientific Diaspora From 2005–2020
Authors: Bonilla Kleinsy , Arrechea Susana , Velásquez Pérez Luis Guillermo
Published: June 2022

In 2005, the Guatemala National Secretariat of Science and Technology (Senacyt) introduced Converciencia, a program designed to connect Guatemalan scientists residing abroad with their country of origin. Converciencia has been a flagship practice for over 15 years. This program involves three main groups of participants: (i) science and technology (S&T) policy agents, (ii) the scientific community (including parts of the Guatemala scientific diaspora, GSD), and (iii) host institutions (local co-organizers, mainly universities, and research institutes). This article presents a comprehensive and balanced overview of the Converciencia program applying an in-depth analysis of its creation, evolution, leading trends, and legacies. Using a qualitative methodology and conducting a four-level analysis (descriptive, explanatory, normative, and prescriptive) allowed for the identification of nuances of this S&T practice in the context of a scientifically lagging country such as Guatemala. The detailed data collected through documentary and desk review, gray literature, focus group discussions, and semi-structured interviews resulted in a framework to highlight the strengths, weaknesses, opportunities, and threats (SWOTs) in the planning, organization, implementation, monitoring, and perception of the results achieved by Converciencia. Findings portray the contrasting views and perceptions from a single S&T practice, depending on the participating parties' roles and responsibilities. Direct participants examined how Converciencia has achieved its objectives while questioning the effectiveness and impact that the resources allocated to the initiative have yielded over time. Evidence indicates that despite the design, coordination, and evaluation limits of Converciencia, the GSD, the scientific community in Guatemala, and the host institutions are interested in the continuity of the practice. Indeed, the main recommendation involves restructuring and turning Converciencia into a robust S&T policy. Converciencia as a policy engaging the GSD could produce greater results and impacts by involving all the key actors in co-designing activities, clearly determining roles and responsibilities, and establishing performance and impact indicators for evaluation.
Surgical Approaches for Prevention of Neuroma at Time of Peripheral Nerve Injury
Authors: Scott Benjamin B. , Winograd Jonathan M. , Redmond Robert W.
Published: June 2022

Painful neuroma is a frequent sequela of peripheral nerve injury which can result in pain and decreased quality of life for the patient, often necessitating surgical intervention. End neuromas are benign neural tumors that commonly form after nerve transection, when axons from the proximal nerve stump regenerate in a disorganized manner in an attempt to recreate nerve continuity. Inflammation and collagen remodeling leads to a bulbous end neuroma which can become symptomatic and result in decreased quality of life. This review covers surgical prophylaxis of end neuroma formation at time of injury, rather than treatment of existing neuroma and prevention of recurrence. The current accepted methods to prevent end neuroma formation at time of injury include different mechanisms to inhibit the regenerative response or provide a conduit for organized regrowth, with mixed results. Approaches include proximal nerve stump capping, nerve implantation into bone, muscle and vein, various pharmacologic methods to inhibit axonal growth, and mechanisms to guide axonal growth after injury. This article reviews historical treatments that aimed to prevent end neuroma formation as well as current and experimental treatments, and seeks to provide a concise, comprehensive resource for current and future therapies aimed at preventing neuroma formation.
Ultrasound-Guided Percutaneous Drainage of Iliopsoas Abscess With Septicemia in an Adolescent: A Case Report and Literature Review
Authors: Jiang Kun , Zhang Wenxiao , Fu Guoyong , Cui Guanghe , Li Xuna , Ren Shousong , Fu Tingliang , Geng Lei
Published: June 2022

Introduction

Iliopsoas abscess with septicemia in the pediatric population is rare. Early diagnosis and effective management of this emergent disorder remain challenging for clinicians.

Case Presentation

A 14-year-old girl presented with right lateral and posterior hip pain and fever for 7 days before admission. Blood culture was positive forStaphylococcus aureus.Enhanced magnetic resonance imaging revealed abscesses located in the right iliopsoas muscle and on the surface deep to the fascia of the right sacroiliac joint that were 6.8 cm × 6.2 cm × 5.7 cm and 3.7 cm × 3.5 cm × 2.1 cm, respectively. A diagnosis of right iliopsoas abscesses with septicemia was made. The patient received intravenous antibiotics, underwent ultrasound-guided percutaneous catheter drainage, and recovered uneventfully. Medical literature regarding this issue published in the English language during the last two decades was reviewed.

Discussion

Primary synchronous psoas and iliacus muscle abscesses are rare and emergent disorders in the pediatric age group. The diagnosis is generally delayed owing to the deep anatomic location and nonspecific signs and symptoms. A comprehensive medical history, meticulous physical examination, and judicious use of imaging studies could establish a timely and accurate diagnosis. Surgeons should be aware of the occurrence of multiple abscesses. Prompt and adequate antibiotic therapy accompanied by a mini-invasive approach, such as ultrasound-guided, laparoscopic, or video-retroperitoneoscopic drainage of the infectious focus, if indicated and feasible, is important to achieve a good outcome in the management of iliopsoas abscess.
Pregnancy and Adverse Obstetric Outcomes After Hysteroscopic Resection: A Systematic Review and Meta-Analysis
Authors: Wu Xue , Zhang Mei , Sun Ping , Jiang Jing-jing , Yan Lei
Published: June 2022

Objective

Although the randomized controlled trial (RCT) of the efficacy of hysteroscopic resection in women with uterine septum has not shown any significant correlation in recent research, motivation for deeper study remains insufficient. In this study, the objective was to determine pregnancy-related outcomes, along with adverse obstetric outcomes, following hysteroscopic resection and also to determine whether women with hysteroscopic resection bear the same outcomes as women with normal uterine cavities.

Search Methods

From January 1995 to February 2022, a systematic literature review was conducted to identify all studies published concerning the gestation outcomes of women with and without hysteroscopic resection while comparing the gestation outcomes of women after hysteroscopic resection and with a normal uterine cavity. Our primary outcome was the live birth rate (LBR). The secondary outcomes were term delivery, preterm delivery, spontaneous miscarriage, malpresentation, cesarean section, and other adverse obstetric outcomes.

Results

22 studies were included in this meta-analysis. The control groups of 14 studies were treated women, and the control groups of the other 8 studies were patients bearing a normal uterine cavity. Hysteroscopic resection was related to a higher rate of term delivery (OR = 2.26, 95% CI, 1.26–4.05), and a lower rate of spontaneous abortion (OR = 0.50, 95% CI, 0.27–0.93), and a lower rate of malpresentation (OR = 0.31, 95% CI, 0.19–0.50). Nevertheless, in comparison with the normal uterus group, the rates of preterm birth, cesarean section, and postpartum hemorrhage after resection did not return to normal levels.

Conclusion

Hysteroscopic resection can effectively reduce the risk of abortion and malpresentation in patients possessing a uterine septum while increasing the term delivery rate. Although well-designed RCTs should confirm our meta-analysis, it still bears recommending to patients
Welfare Indicators in Tilapia: An Epidemiological Approach
Authors: Flores-García Luis , Camargo-Castellanos Juan C. , Pascual-Jímenez Cristina , Almazán-Rueda Pablo , Monroy-López Jorge Francisco , Albertos-Alpuche Pedro J. , Martínez-Yáñez Rosario
Published: June 2022

Interest and concern about rearing methods and their impact on animal welfare have increased. Production evaluation is population-based, and animal welfare analysis should be similar. In fish, the most common welfare indicators are gill state, fin damage, and body condition. The objective of this study was to evaluate the feeding rate effect on the welfare indicators of Oreochromis niloticus using an epidemiological approach. Five growth stages (from 1.2 to 360 g) were studied using four feeding rates as treatments: underfeeding (80%), recommended feeding (100%), and two levels of overfeeding (120% and 140%). The evaluated welfare indicators include the presence of lesions in different body areas and fins, the decrease in body condition index, and their impact on biomass production. Incidence and relative risk were determined for each indicator. Statistically significant associations were found in the indicators of mortality, weight, body condition (K), and presence of evident damage in the caudal and anal fin in all stages. The results showed that the feed rate directly affects the welfare indicators and production. Mortality, weight reduction, K reduction, and caudal and anal fin damage incidence showed to be relevant indicators in all O. niloticus growing stages. As a result of this study, the epidemiological approach seems to be a valuable tool for production. A risk traffic light method is a proposal that could have great potential, with the suggested limits for WI's concerning the individuals present in the culture pond, allowing progressive evaluation and decision-making to correct risky situations.
Vaccine-Linked Chemotherapy Approach: Additive Effects of Combining the Listeria monocytogenes-Based Vaccine Lm3Dx_NcSAG1 With the Bumped Kinase Inhibitor BKI-1748 Against Neospora caninum Infection in Mice
Authors: Imhof Dennis , Pownall William Robert , Schlange Carling , Monney Camille , Ortega-Mora Luis-Miguel , Ojo Kayode K. , Van Voorhis Wesley C. , Oevermann Anna , Hemphill Andrew
Published: June 2022

The apicomplexan parasite Neospora (N.) caninum causes neosporosis in numerous host species. There is no marketed vaccine and no licensed drug for the prevention and/or treatment of neosporosis. Vaccine development against this parasite has encountered significant obstacles, probably due to pregnancy-induced immunomodulation hampering efficacy, which has stimulated the search for potential drug therapies that could be applied to limit the effects of neosporosis in dams as well as in offspring. We here investigated, in a pregnant neosporosis mouse model, the safety and efficacy of a combined vaccination-drug treatment approach. Mice were vaccinated intramuscularly with 1 × 107 CFU of our recently generated Listeria (L.) monocytogenes vaccine vector expressing the major N. caninum tachyzoite surface antigen NcSAG1 (Lm3Dx_SAG1). Following mating and experimental subcutaneous infection with 1 × 105N. caninum (NcSpain-7) tachyzoites on day 7 of pregnancy, drug treatments were initiated using the bumped kinase inhibitor BKI-1748 at 20 mg/kg/day for 5 days. In parallel, other experimental groups were either just vaccinated or only treated. Dams and offspring were followed-up until day 25 post-partum, after which all mice were euthanized. None of the treatments induced adverse effects and neither of the treatments affected fertility or litter sizes. Cerebral infection in dams as assessed by real-time PCR was significantly reduced in the vaccinated and BKI-1748 treated groups, but was not reduced significantly in the group receiving the combination. However, in non-pregnant mice, all three treatment groups exhibited significantly reduced parasite burdens. Both, vaccination as well BKI-1748 as single treatment increased pup survival to 44 and 48%, respectively, while the combination treatment led to survival of 86% of all pups. Vertical transmission in the combination group was 23% compared to 46 and 50% in the groups receiving only BKI-treatment or the vaccine, respectively. In the dams, IgG titers were significantly reduced in all treatment groups compared to the untreated control, while in non-pregnant mice, IgG titers were reduced only in the group receiving the vaccine. Overall, vaccine-linked chemotherapy was more efficacious than vaccination or drug treatment alone and should be considered for further evaluation in a more relevant experimental model.
Integrated Bacteria-Fungi Diversity Analysis Reveals the Gut Microbial Changes in Buffalo With Mastitis
Authors: Chen Xiushuang , An Miao , Zhang Wenqian , Li Kun , Kulyar Muhammad Fakhar-e-Alam , Duan Kun , Zhou Hui , Wu Yu , Wan Xin , Li Jianlong , Quan Lingtong , Mai Zhanhai , Bai Wenxia , Wu Yi
Published: June 2022

The gut microbial community is closely related to mastitis, but studies regarding the influences of mastitis on gut microbiota in buffalo remain scarce. Herein, we characterized the differences in gut bacterial and fungal communities between mastitis-affected and healthy buffalos. Interestingly, although mastitis had no effect on gut bacterial and fungal diversities in the buffalos, some bacterial and fungal taxa were significantly altered. Bacterial and fungal taxonomic analysis showed that the preponderant bacterial phyla (Firmicutes and Bacteroidetes) and fungal phyla (Ascomycota and Basidiomycota) in buffalo were the same regardless of health status. At the level of genus, the changes in some gut bacterial and fungal abundances between both groups were gradually observed. Compared with healthy buffalos, the proportions of 3 bacterial genera (uncultured_bacterium_f_Muribaculaceae, Eubacterium_nodatum_group, and Lachnoclostridium_10) and 1 fungal genus (Pichia) in the mastitis-affected buffalo were significantly increased, whereas 4 bacterial genera (Ruminococcus_2, Candidatus_Stoquefichus, Turicibacter, and Cellulosilyticum) and 4 fungal genera (Cladosporium, Thermothelomyces, Ganoderma and Aspergillus) were significantly decreased. Taken together, this research revealed that there was significant difference in the compositions of the gut microbial community between the healthy and mastitis-affected buffalos. To our knowledge, this is the first insight into the characteristics of the gut microbiota in buffalos with mastitis, which is beneficial to understand the gut microbial information of buffalo in different health states and elucidate the pathogenesis of mastitis from the gut microbial perspective.
Swarm Intelligence with Deep Transfer Learning Driven Aerial Image Classification Model on UAV Networks
Authors: S. Alotaibi Saud , Abdullah Mengash Hanan , Negm Noha , Marzouk Radwa , Hilal Anwer Mustafa , Shamseldin Mohamed A. , Motwakel Abdelwahed , Yaseen Ishfaq , Rizwanullah Mohammed , Zamani Abu Sarwar
Published: June 2022

Nowadays, unmanned aerial vehicles (UAVs) have gradually attracted the attention of many academicians and researchers. The UAV has been found to be useful in variety of applications, such as disaster management, intelligent transportation system, wildlife monitoring, and surveillance. In UAV aerial images, learning effectual image representation was central to scene classifier method. The previous approach to the scene classification method depends on feature coding models with lower-level handcrafted features or unsupervised feature learning. The emergence of convolutional neural network (CNN) is developing image classification techniques more effectively. Due to the limited resource in UAVs, it can be difficult to fine-tune the hyperparameter and the trade-offs amongst computation complexity and classifier results. This article focuses on the design of swarm intelligence with deep transfer learning driven aerial image classification (SIDTLD-AIC) model on UAV networks. The presented SIDTLD-AIC model involves the proper identification and classification of images into distinct kinds. For accomplishing this, the presented SIDTLD-AIC model follows a feature extraction module using RetinaNet model in which the hyperparameter optimization process is performed by the use of salp swarm algorithm (SSA). In addition, a cascaded long short term memory (CLSTM) model is executed for classifying the aerial images. At last, seeker optimization algorithm (SOA) is applied as a hyperparameter optimizer of the CLSTM model and thereby results in enhanced classification accuracy. To assure the better performance of the SIDTLD-AIC model, a wide range of simulations are implemented and the outcomes are investigated in many aspects. The comparative study reported the better performance of the SIDTLD-AIC model over recent approaches.
The Differential Clinical Impacts of Cachexia and Sarcopenia on the Prognosis of Advanced Pancreatic Cancer
Authors: Hou Ya-Chin , Chen Chien-Yu , Huang Chien-Jui , Wang Chih-Jung , Chao Ying-Jui , Chiang Nai-Jung , Wang Hao-Chen , Tung Hui-Ling , Liu Hsiao-Chun , Shan Yan-Shen
Published: June 2022

Pancreatic cancer (PC) has the highest frequency of developing cancer cachexia (CC)–sarcopenia (SC) syndrome, which negatively influences patients’ outcome, quality of life, and tolerance/response to treatments. However, the clinical impacts of CC, SC, and their associated factors on outcomes for advanced PC has yet to be fully investigated. A total of 232 patients were enrolled in this study for the retrospective review of their clinical information and the measurement of skeletal muscle areas at the third lumber vertebra by computed tomography scan to identify CC or SC. The association and concurrent occurrence of clinicopathological features in each patient, prevalence rates, and prognosis with the CC or SC were calculated. CC and SC were observed in 83.6% (n = 194) and 49.1% (n = 114) of PC patients, respectively. Low hemoglobin levels more often occurred in CC patients than in non-CC patients (p = 0.014). Older age (p = 0.000), female gender (p = 0.024), low body mass index (BMI) values (p = 0.004), low hemoglobin levels (p = 0.036), and low albumin levels (p = 0.001) were more often found in SC patients than in non-SC patients. Univariate and multivariate analyses showed that CC was an independent poor prognostic factor of overall survival (OS) and progression-free survival for all patients, the chemotherapy (C/T) subgroup, and the high BMI subgroup. Meanwhile, SC was an independent predictor of poor OS for the subgroups of C/T or high BMI but not for all patients. These findings reveal the clinical differences for CC and SC and provide useful information for predicting the prognosis of advanced PC patients and conducting personalized medicine.
Hydrogen and CNT Production by Methane Cracking Using Ni–Cu and Co–Cu Catalysts Supported on Argan-Derived Carbon
Authors: Cazaña Fernando , Afailal Zainab , González-Martín Miguel , Sánchez José Luis , Latorre Nieves , Romeo Eva , Arauzo Jesús , Monzón Antonio
Published: June 2022

The 21st century arrived with global growth of energy demand caused by population and standard of living increases. In this context, a suitable alternative to produce COx-free H2 is the catalytic decomposition of methane (CDM), which also allows for obtaining high-value-added carbonaceous nanomaterials (CNMs), such as carbon nanotubes (CNTs). This work presents the results obtained in the co-production of COx-free hydrogen and CNTs by CDM using Ni–Cu and Co–Cu catalysts supported on carbon derived from Argan (Argania spinosa) shell (ArDC). The results show that the operation at 900 °C and a feed-ratio CH4:H2 = 2 with the Ni–Cu/ArDC catalyst is the most active, producing 3.7 gC/gmetal after 2 h of reaction (equivalent to average hydrogen productivity of 0.61 g H2/gmetal∙h). The lower productivity of the Co–Cu/ArDC catalyst (1.4 gC/gmetal) could be caused by the higher proportion of small metallic NPs (<5 nm) that remain confined inside the micropores of the carbonaceous support, hindering the formation and growth of the CNTs. The TEM and Raman results indicate that the Co–Cu catalyst is able to selectively produce CNTs of high quality at temperatures below 850 °C, attaining the best results at 800 °C. The results obtained in this work also show the elevated potential of Argan residues, as a representative of other lignocellulosic raw materials, in the development of carbonaceous materials and nanomaterials of high added-value.
Limitations in Modelling Reinforced Concrete Durability
Authors: Atkins Chris , Lambert Paul
Published: June 2022

The design processes for reinforced concrete are changing. More often, durability targets are being achieved by using modelling. This paper compares some of the models available and the precision undertaken to obtain the data that underpins the calculations, and it reflects on the change in the environment that is known to be occurring. In addition, a review of the sustainability implications of durability is considered. It is concluded that there may be more sustainable methods to achieve a long life than simply increasing cement contents and covers.
Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival
Authors: Hassan Mohamed , Ehle Benjamin , Passlick Bernward , Grapatsas Konstantinos
Published: June 2022

Background: Pulmonary metastasectomy (PM) is an established treatment option for selected patients with stage IV solid tumors. The aim of this study was to investigate the feasibility of and survival rate in PM for elderly patients. Methods: We retrospectively analyzed all of the patients who underwent PM with curative intention at our institution. The patients were categorized into two groups: the elderly group (≥70 years old) and the non-elderly group (<70 years old). Results: The elderly group consisted of 222 patients versus 538 patients in the non-elderly group. The median number of resected metastases was 2 ± 3 in the elderly group and 4 ± 5 in the non-elderly group (p < 0.01). No difference in the rate of postoperative complications was observed between the two groups (p = 0.3). The median length of hospital stay in each group was comparable (10 ± 5 vs. 10 ± 4.3 days, p = 0.3). The 5-year survival rate was 67% in the elderly group and 78% in the non-elderly group (p = 0.117). In the univariate analysis, COPD was associated with poor survival in the elderly group (p = 0.002). Conclusion: The resection of pulmonary metastases in elderly patients is safe, is not associated with increased risks of postoperative complication, and the survival benefit is not reduced in selected patients.
Twin Shear Unified Strength Solution of Shale Gas Reservoir Collapse Deformation in the Process of Shale Gas Exploitation
Authors: Cui Ying , Qu Zhan , Wang Liang , Wang Ping , Fang Jun
Published: June 2022

The collapse deformation of shale has a significant influence on the exploitation process. Experimental analysis has indicated a correlation coefficient range from 0.9814 to 0.9981 and the established sample regression formula could be used to express the relationship between the dynamic elastic modulus and static elastic modulus of shale specimens. Based on the twin shear unified-strength theory, where coefficient b was considered to express the effect of intermediate principal stress, with the deduced regression formula, the unified solution of major principal strains describing a critical collapse of the shale shaft wall was derived. The results showed that the intermediate principal stress had a significant influence on the major principal strain, describing the critical collapse of the shale shaft wall. At the same depth, the critical collapse major principal strain increased with the increase in the b values. With the change in b value from 0 to 1, the calculated difference in critical collapse major principal strain with the same wellbore depth would change from 22.1% to 45.5%. With the change in b value from 0 to 1, the calculated difference in critical collapse major principal strain with the same wellbore temperature would change from 22.1% to 45.6%. The unified solution formula of the major principal strain, describing the critical collapse of the shale shaft wall expressed by the dynamic elastic modulus, could adjust the contribution of intermediate principal stress by changing the values of b, while considering the influence of temperature and confining pressure. The twin shear unified-strength solution of the shale gas reservoir collapse deformation could be used to effectively evaluate the shale gas reservoir stability during shale gas exploitation.
Resilience Neural-Network-Based Methodology Applied on Optimized Transmission Systems Restoration
Authors: Tosic Josip , Skok Srdjan , Teklic Ljupko , Balkovic Mislav
Published: June 2022

This paper presents an advanced methodology for restoration of the electric power transmission system after its partial or complete failure. This load-optimized restoration is dependent on sectioning of the transmission system based on artificial neural networks. The proposed methodology and the underlying algorithm consider the transmission system operation state just before the fallout and, based on this state, calculate the power grid parameters and suggest the methodology for system restoration for each individual interconnection area. The novel methodology proposes an optimization objective function as a maximum load recovery under a set of constraints. The grid is analyzed using a large amount of data, which results in an adequate number of training data for artificial neural networks. Once the artificial neural network is trained, it provides an almost instantaneous network recovery plan scheme by defining the direct switching order.
Deoxyshikonin Mediates Heme Oxygenase-1 Induction and Apoptotic Response via p38 Signaling in Tongue Cancer Cell Lines
Authors: Chuang Chun-Yi , Lin Chiao-Wen , Su Chun-Wen , Chen Yi-Tzu , Yang Wei-En , Yang Shun-Fa , Su Shih-Chi
Published: June 2022

Deoxyshikonin (DSK), a phytochemical constituent, has been documented to elicit various oncostatic properties alone or in combination with established therapeutics. However, its role in restraining oral squamous cell carcinoma (OSCC) is mostly unclear. Here, we examined the tumor-suppressive effect of DSK and explored the molecular mechanisms underlying DSK’s activities on controlling oral cancer. Our results showed that DSK dose-dependently lessened the cell viability of tongue cancer cell lines, involving induction of cell cycle arrest at the sub-G1 phase and apoptotic cell death. Moreover, a unique signature of apoptosis-related proteins, including augmented nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) expression and caspase activation, was observed in DSK-treated tongue cancer cell lines. Furthermore, DSK-mediated upregulation of HO-1 and cleavage of caspase-9 and -3 were significantly inhibited by pharmacological blockage of p38 kinase. Collectively, these data revealed that DSK halted cell cycle progression and elicited cell apoptosis in tongue cancer cell lines, reshaping a p38-dependent profile of apoptotic proteome. Our findings provided novel insights into the therapeutic implications of a natural compound on the management of OSCC.
Resurrecting Urban Heritage with Contemporary Adaption: The Reconstruction of the Porcelain Tower in Nanjing (China)
Authors: Ma Pengfei , Li Mengbi , Li Xiangning
Published: June 2022

This article explores how reconstruction design can be used in urban heritage as an adaptive approach to creating a continuous cultural dynamic for urban regeneration. The case that is studied is the rebuilding project of the Porcelain Tower of Nanjing, well-known to westerners as a splendour of the East. The research strategy stems from the epistemological paradigm of interpretivism and relies mainly on qualitative research methods. The ethic of refashioning a past legacy is discussed by reviewing the relevant theories and documents. It is argued that the rationale for rebuilding heritage should be judged on a case-by-case basis. From the perspective of urban cultural regeneration, rebuilding can be an appropriate solution to reviving heritage within the bounds of authenticity. Respecting the delicate balance between historical significance and contemporary sustainability, urban heritage can sometimes best be served by modern reconstruction. This paper, therefore, identifies the modern Porcelain Tower as an urban landmark that distinguishes Nanjing among Chinese cities and satisfies the cultural demand for sustainable local urban regeneration. Whilst the modern pagoda is not historically inaccurate, its reconstruction was determined without public engagement in a way that emphasises the government’s view of its history and value.
Discovery of Small Molecules from Echinacea angustifolia Targeting RNA-Dependent RNA Polymerase of Japanese Encephalitis Virus
Authors: Yadav Pardeep , El-Kafrawy Sherif A. , El-Day Mai M. , Alghafari Wejdan T. , Faizo Arwa A. , Jha Saurabh Kumar , Dwivedi Vivek Dhar , Azhar Esam I.
Published: June 2022

The Japanese encephalitis virus (JEV), a mosquito-borne flavivirus that causes viral encephalitis leading to neural damage, is a major threat in most Asian countries. The RNA-dependent RNA polymerase (RdRp) present in the viral genome is the key component for genome replication, making it an attractive target for antiviral drug development. In this study, the natural products from Echinacea angustifolia were retrieved for structure-based virtual screening against JEV–RdRp. The top six compounds (Echinacoside, Echinacin, Rutin, Cynaroside, Quercetagetin 7-glucoside, and Kaempferol-3-glucoside) were obtained based on the highest negative docking score, ADMET (absorption, distribution, metabolism, excretion, and toxicity), and molecular interaction. The computational analysis of these selected compounds against the co-crystallized ligands, i.e., ATP and GTP, were performed. Further, 100 ns molecular dynamic simulation and post-free binding energy calculation of all the selected compounds complexed with JEV–RdRP were performed to check the stability of the complexes. The obtained results showed considerable stability and intermolecular interaction with native ligand-binding site residues of JEV–RdRp. Hence, selected natural compounds are admissible inhibitors of JEV–RdRp protein and can be considered for future antiviral drug development studies.
Analysis of the Importance of the Motion Used in the Resistance of Different Mechanical Instrumentation Systems in Endodontics: A Comparative Study
Authors: Mena-Álvarez Jesús , Almanzor-López Manuel , Quispe-López Norberto , De Pedro-Muñoz Ana , Rico-Romano Cristina
Published: June 2022

Aim: The aim of this study was to compare the cyclic fatigue strength of different reciprocating rotary systems depending on the movement used. Methods: Four study groups were analyzed (n = 30): (1) Reciproc®, (2) Reciproc Blue®, (3) Wave One Gold® and (4) Procodile®. Each group was divided into three subgroups according to the motion used: (A) Reflex Dynamic® (n = 10), (B) ReFlex Smart® (n = 10) and (C) conventional reciprocating motion (n = 10). They were used in a dynamic cyclic fatigue prototype until their fracture, and the time was measured in seconds. The results obtained were analyzed with the ANOVA method, and for two-to-two comparisons, the Tukey method and Weibull statistics were used. Results: Procodile ReFlex Smart had the longest time to failure, and statistically significant differences were found between Procodile ReFlex Smart and the other files and motions (p < 0.05). Conclusion: Smart motions increase cyclic fatigue strength. ReFlex Smart® motion increases the cyclic fatigue strength of reciprocating rotary systems, and Procodile® ReFlex Smart was the most resistant system file.
Photonics with Gallium Nitride Nanowires
Authors: Alwadai Norah , Saleman Nigza , Elqahtani Zainab Mufarreh , Khan Salah Ud-Din , Majid Abdul
Published: June 2022

The surface plasmon resonance in low-dimensional semiconducting materials is a source of valuable scientific phenomenon which opens widespread prospects for novel applications. A systematic study to shed light on the propagation of plasmons at the interface of GaN nanowire is reported. A comprehensive analysis of the interaction of light with GaN nanowires and the propagation of plasmons is carried out to uncover further potentials of the material. The results obtained on the basis of calculations designate the interaction of light with nanowires, which produced plasmons at the interface that propagate along the designed geometry starting from the center of the nanowire towards its periphery, having more flux density at the center of the nanowire. The wavelength of light does not affect the propagation of plasmons but the flux density of plasmons appeared to increase with the wavelength. Similarly, an increment in the flux density of plasmons occurs even in the case of coupled and uncoupled nanowires with wavelength, but more increment occurs in the case of coupling. Further, it was found that an increase in the number of nanowires increases the flux density of plasmons at all wavelengths irrespective of uniformity in the propagation of plasmons. The findings point to the possibility of tuning the plasmonics by using a suitable number of coupled nanowires in assembly.