bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasonographic Estimation of Total Brain Volume: 3D Reliability and 2D Estimation. Enabling Routine Estimation During NICU Admission in the Preterm Infant
Authors: Benavente-Fernández Isabel , Ruiz-González Estefanía , Lubian-Gutiérrez Manuel , Lubián-Fernández Simón Pedro , Cabrales Fontela Yunior , Roca-Cornejo Cristina , Olmo-Duran Pedro , Lubián-López Simón Pedro
Published: July 2021

Objectives: The aim of this study is to explore if manually segmented total brain volume (TBV) from 3D ultrasonography (US) is comparable to TBV estimated by magnetic resonance imaging (MRI). We then wanted to test 2D based TBV estimation obtained through three linear axes which would enable monitoring brain growth in the preterm infant during admission.

Methods: We included very low birth weight preterm infants admitted to our neonatal intensive care unit (NICU) with normal neuroimaging findings. We measured biparietal diameter, anteroposterior axis, vertical axis from US and MRI and TBV from both MRI and 3D US. We calculated intra- and interobserver agreement within and between techniques using the intraclass correlation coefficient and Bland-Altman methodology. We then developed a multilevel prediction model of TBV based on linear measurements from both US and MRI, compared them and explored how they changed with increasing age. The multilevel prediction model for TBV from linear measures was tested for internal and external validity and we developed a reference table for ease of prediction of TBV.

Results: We used measurements obtained from 426 US and 93 MRI scans from 118 patients. We found good intra- and interobserver agreement for all the measurements. US measurements were reliable when compared to MRI, including TBV which achieved excellent agreement with that of MRI [ICC of 0.98 (95% CI 0.96–0.99)]. TBV estimated through 2D measurements of biparietal diameter, anteroposterior axis, and vertical axis was comparable among both techniques. We estimated the population 95% confidence interval for the mean values of biparietal diameter, anteroposterior axis, vertical axis, and total brain volume by post-menstrual age. A TBV prediction table based on the three axes is proposed to enable easy implementation of TBV estimation in routine 2D US during admission in the NICU.

Conclusions: US measurements of biparietal diameter, vertical axis, and anteroposterior axis are reliable. TBV segmented through 3D US is comparable to MRI estimated TBV. 2D US accurate estimation of TBV is possible through biparietal diameter, vertical, and anteroposterior axes.
rhKGF-2 Attenuates Smoke Inhalation Lung Injury of Rats via Activating PI3K/Akt/Nrf2 and Repressing FoxO1-NLRP3 Inflammasome
Authors: Fu Zhonghua , Jiang Zhengying , Guo Guanghua , Liao Xincheng , Liu Mingzhuo , Xiong Zhenfang
Published: July 2021

Smoke inhalation injury is an acute pathological change caused by thermal stimulation or toxic substance absorption through respiratory epithelial cells. This study aims to probe the protective effect and mechanism of recombinant human keratinocyte growth factor 2 (rhKGF-2) against smoke inhalation-induced lung injury (SILI) in rats. The SILI was induced in rats using a smoke exposure model, which were then treated with rhKGF-2. The rat blood was collected for blood-gas analysis, and the levels of inflammatory factors and oxidative stress markers in the plasma were measured. The rat lung tissues were collected. The pathological changes and cell apoptosis were determined by hematoxylin-eosin (HE) staining and TdT-mediated dUTP nick end labeling (TUNEL) assay, and the PI3K/Akt/Nrf2/HO-1/NQO1, and FoxO1-NLRP3 inflammasome expression were verified by western blot (WB). Both of the human alveolar epithelial cell (HPAEpiC) and primary rat alveolar epithelial cell were exposed to lipopolysaccharide (LPS) for making in-vitro alveolar epithelial cell injury model. After treatment with rhKGF-2, GSK2126458 (PI3K inhibitor) and AS1842856 (FoxO1 inhibitor), the cell viability, apoptosis, inflammation, oxidative stress, reactive oxygen species (ROS), PI3K/Akt/Nrf2, HO-1/NQO1, and FoxO1-NLRP3 in HPAEpiC and primary rat alveolar epithelial cell were examined. The data suggested that rhKGF-2 reduced LPS-induced HPAEpiC cell and primary rat alveolar epithelial cell apoptosis and the expression of inflammatory factors and oxidative stress factors. Moreover, rhKGF-2 improved the blood gas and alleviated SILI-induced lung histopathological injury in vivo via repressing inflammation, NLRP3 inflammasome activation and oxidative stress. Mechanistically, rhKGF-2 activated PI3K/Akt pathway, enhanced Nrf2/HO-1/NQO1 expression, and attenuated FoxO1-NLRP3 inflammasome both in vitro and in vivo. However, pharmaceutical inhibition of PI3K/Akt pathway attenuated rhKGF-2-mediated protective effects against SILI, while suppressing FoxO1 promoted rhKGF-2-mediated protective effects. Taken together, this study demonstrated that rhKGF-2 mitigated SILI by regulating the PI3K/Akt/Nrf2 pathway and the FoxO1-NLRP3 axis, which provides new reference in treating SILI.
Anti-Obesity and Lipid Lowering Activity of Bauhiniastatin-1 is Mediated Through PPAR-γ/AMPK Expressions in Diet-Induced Obese Rat Model
Authors: Karunakaran Reddy Sankaran , Lokanatha Oruganti , Muni Swamy Ganjayi , Venkataramaiah Chintha , Muni Kesavulu Muppuru , Appa Rao Chippada , Badri Kameswara Rao , Balaji Meriga
Published: July 2021

Objective: To evaluate the therapeutic efficacy and underlying molecular mechanisms of Bauhiniastatin-1 (BSTN1) to alleviate adiposity in diet-induced obese rodent model and in 3T3-L1 cells.

Methods: BSTN1 was purified and confirmed through HPLC. In-vitro experiments such as MTT assay, Oil Red-O (ORO) stain, cellular lipid content, glycerol release and RT-PCR analysis were performed in 3T3-L1 cells in the presence and absence of BSTN1. In animal experiments, rats were divided into Group-I: normal pellet diet-fed, Group-II: HFD-fed, Groups-III, IV and V: HFD-fed BSTN1 (1.25, 2.5, and 5 mg/kg.b.wt./day/rat)-treated and Group-VI: HFD-fed Orlistat-treated. The rats were fed either normal diet or high fat diet (HFD) for 18 weeks and water ad-libitum. BSTN1 was orally administered from 13th week onwards to the selected HFD-fed groups. Body composition parameters, biochemical assays, histopathology examination and western blot analysis were performed to identify the predicted targets related to obesity. Molecular docking studies threw light on the binding interactions of BSTN1 against PPAR-γ, FAS and AMPK.

Results: BSTN1 at 20 μM significantly (p < 0.001) inhibited adipocyte differentiation and lipid accumulation in 3T3-L1 cells. A conspicuous down-regulation in the mRNA expression levels of PPAR-γ, FAS and SREBP1 was observed but AMPK expression remained unchanged in BSTN1 treated 3T3-L1 cells. A substantial decrease in body weight gain, fat percent, total body fat, serum and liver lipid profile (except high-density lipoprotein), glucose, insulin and insulin resistance in BSTN1 treated rats was noticed in a dose dependent manner. In BSTN1 (5 mg/kg.b.wt.)-treated groups significantly (p < 0.01) elevated plasma adiponectin level but reduced leptin level as well as fall in serum AST and ALT were noticed. Further, the disturbed structural integrity and architecture of adipose and hepatic tissues due to high fat diet feeding were considerably recovered with BSTN1 treatment. Down-regulation in the protein expression level of PPAR-γ and activation of AMPK through phosphorylation was observed in BSTN1 treated rats than the untreated. Molecular docking studies revealed strong binding interactions of BSTN1 against PPAR-γ and AMPK and thus supported the experimental results.

Conclusion: Taken together, the results suggest that BSTN1 could be a promising pharmacological molecule in the treatment of obesity and dyslipidemia.
Beneficial Effects of Polysaccharides on the Epithelial Barrier Function in Intestinal Mucositis
Authors: Sauruk da Silva Karien , Carla da Silveira Bruna , Bueno Laryssa Regis , Malaquias da Silva Liziane Cristine , da Silva Fonseca Lauany , Fernandes Elizabeth Soares , Maria-Ferreira Daniele
Published: July 2021

Intestinal mucositis is a clinically relevant side effect of anticancer therapies. It is experienced by 60–100% of patients undergoing treatment with high doses of chemotherapy, radiation therapy, and bone marrow transplantation. Intestinal mucositis can manifest as pain, weight loss, inflammation, diarrhea, rectal bleeding, and infection; affecting normal nutritional intake and intestinal function. It often impacts adherence to anticancer therapy as it frequently limits patient’s ability to tolerate treatment, causing schedule delays, interruptions, or premature discontinuation. In some cases, local and systemic secondary infections are observed, increasing the costs toward medical care and hospitalization. Several strategies for managing mucositis are available which do not always halt this condition. In this context, new therapeutic strategies are under investigation to prevent or treat intestinal mucositis. Polysaccharides from natural resources have recently become promising molecules against intestinal damage due to their ability to promote mucosal healing and their anti-inflammatory actions. These effects are associated with the protection of intestinal mucosa and regulation of microbiota and immune system. This review aims to discuss the recent advances of polysaccharides from natural resources as potential therapies for intestinal mucositis. The source, species, doses, treatment schedules, and mechanisms of action of polysaccharides will be discussed in detail.
Site-Specific Glycosylation of Recombinant Viral Glycoproteins Produced in Nicotiana benthamiana
Authors: Margolin Emmanuel , Allen Joel D. , Verbeek Matthew , van Diepen Michiel , Ximba Phindile , Chapman Rosamund , Meyers Ann , Williamson Anna-Lise , Crispin Max , Rybicki Edward
Published: July 2021

There is an urgent need to establish large scale biopharmaceutical manufacturing capacity in Africa where the infrastructure for biologics production is severely limited. Molecular farming, whereby pharmaceuticals are produced in plants, offers a cheaper alternative to mainstream expression platforms, and is amenable to rapid large-scale production. However, there are several differences along the plant protein secretory pathway compared to mammalian systems, which constrain the production of complex pharmaceuticals. Viral envelope glycoproteins are important targets for immunization, yet in some cases they accumulate poorly in plants and may not be properly processed. Whilst the co-expression of human chaperones and furin proteases has shown promise, it is presently unclear how plant-specific differences in glycosylation impact the production of these proteins. In many cases it may be necessary to reproduce features of their native glycosylation to produce immunologically relevant vaccines, given that glycosylation is central to the folding and immunogenicity of these antigens. Building on previous work, we transiently expressed model glycoproteins from HIV and Marburg virus in Nicotiana benthamiana and mammalian cells. The proteins were purified and their site-specific glycosylation was determined by mass-spectrometry. Both glycoproteins yielded increased amounts of protein aggregates when produced in plants compared to the equivalent mammalian cell-derived proteins. The glycosylation profiles of the plant-produced glycoproteins were distinct from the mammalian cell produced proteins: they displayed lower levels of glycan occupancy, reduced complex glycans and large amounts of paucimannosidic structures. The elucidation of the site-specific glycosylation of viral glycoproteins produced in N. benthamiana is an important step toward producing heterologous viral glycoproteins in plants with authentic human-like glycosylation.
Analytic Thinking and Political Orientation in the Corona Crisis
Authors: Maglić Marina , Pavlović Tomislav , Franc Renata
Published: July 2021

With much unknown about the new coronavirus, the scientific consensus is that human hosts are crucial to its spread and reproduction—the more people behave like regular socializing beings they are, the more likely it is that the virus will propagate. Hence, many nations worldwide have mandated physical-distancing measures. In the current preregistered research, we focus on examining two factors that may help explain differences in adherence to COVID-19 preventive behaviors and policy support across different countries—political orientation and analytic thinking. We positioned our research within the dual-process framework of human reasoning and investigated the role of cognitive reflection, open-minded thinking, and political ideology in determining COVID-19 responsible behavior (physical distancing and maintaining hygiene) and support for restrictive COVID-19 policies on a sample of 12,490 participants from 17 countries. We have not been able to detect substantial relationships of political orientation with preventive behaviors and policy support, and overall found no reliable evidence of politicization, nor polarization regarding the issue. The results of structural equation modeling showed that the inclination towards COVID-19 preventive measures and their endorsement were defined primarily by the tendency of open-minded thinking. Specifically, open-minded thinking was shown to be a predictor of all three criteria—avoiding physical contact, maintaining physical hygiene, and supporting COVID-19 restrictive mitigation policies. Cognitive reflection was predictive of lesser adherence to stricter hygiene and only very weakly predictive of lesser policy support. Furthermore, there was no evidence of these effects varying across political contexts. The mediation analysis suggested a partial mediation effect of COVID-19 conspiracy beliefs on the relationships of open-mindedness and cognitive reflection with physical distancing (but not adherence to stricter hygiene) and COVID-19 policy support, albeit very small and significant primarily due to sample size. There was also no evidence of these effects varying across political contexts. Finally, we have not been able to find strong evidence of political orientation modifying the relationship between analytical thinking and COVID-19 behaviors and policy support, although we explored the pattern of these effects in the US and Canadian samples for exploratory purposes and comparison with other similar studies.
Parental Reports of Preschoolers' Lexical and Syntactic Development: Validation of the CDI-III for European Portuguese
Authors: Cadime Irene , Santos Ana Lúcia , Ribeiro Iolanda , Viana Fernanda Leopoldina
Published: July 2021

This study presents the validation analysis of the European Portuguese version of the MacArthur-Bates Communicative Development Inventory III (CDI-III-PT). The CDI-III-PT is a parental report measure allowing researchers to assess expressive vocabulary and the syntactic abilities of children aged 2;6–4;0. In this study, we present a version comprising a lexical subscale which follows the Swedish adaptation and an original syntactic subscale allowing us to include language-specific structures. The reports of 739 children were collected; in addition, a standardized measure of language was also administered to a sub-sample of these children and the reports of preschool teachers were collected for another sub-sample. The results indicate a high internal consistency of the lexical and syntactic subscales. As for sociodemographic variables often found to be predictors of language development, as measured by this type of instrument, the results indicate that age and maternal education are significant predictors of the scores, and that first-born children attain higher scores in vocabulary than later born children, but no significant gender differences were found. The scores of the CDI-III-PT are positively correlated with the ones obtained in the standardized language measure, thus supporting their validity. A high agreement between the reports of parents and teachers was also found. These findings indicate that the CDI-III-PT has adequate psychometric properties and that it can be a useful tool for research and clinical practice. The age-based norms that are now provided can be used to evaluate whether a child is performing poorly compared to their peers.
Constructing and Validating Students’ Psychological Contract Violation Scale
Authors: Itzkovich Yariv
Published: July 2021

For two and a half decades, psychological contracts are researched mainly in work organisations as drivers of the attitudes and behaviours of employees, overlooking the importance of understanding the nature of the psychological contracts of students in higher education. This study constructs and validates a new scale for measuring the perceived psychological contract violations of students in the context of faculty incivility. A mixed-method approach was applied to study the issue in three phases. First, a qualitative method was used to capture and analyse the perceived entitlements of students, as described by 78 college students, resulting in 37 items or elements identified by students as reflecting their psychological contracts. Second, a sample of 244 students was studied to identify the perceptions of violated expectations of students. In the final phase, items were rephrased as expectations and were given to the third sample of 154 undergraduate college students to determine the level of fulfilment of these expectations. Additionally, to ascertain discriminate and convergent validity measures, students were asked about the extent to which they experienced faculty incivility (discriminant validity) and frustration with the quality of interaction with their faculty (convergent validity). From these results, students’ psychological contract violation scale was constructed and validated.
Does Alice Live Here Anymore? Autonomy and Identity in Persons Living and Dying With Dementia
Authors: D'cruz Migita M.
Published: July 2021

Conventional scientific definitions of dementia, or its newer proposed alternate—neurocognitive disorders place emphasis upon cognitive function, particularly memory. The changes in thought, emotion, behavior, personality, and biological function are usually considered only of secondary importance. At the core of the illness, however, lies a progressive loss of self, and by extension, of personhood, identity, autonomy, and agency. The identity of the person living with dementia, and the deterioration of a sense of self assumes significance in planning end of life care, including palliative care. A consideration of self and identity is also significant where physician assisted death, incorporating euthanasia, has legal sanctity. As dementia progresses, there is usually a progressive loss of personal decision making capacity and legal competence. Shared decision making, advance care directives and proxy representatives are options available to safeguard autonomy and agency in such cases. Advance care directives are often treated as static documents. The loss of self and deterioration of identity in persons with dementia means, that there is a psychological discontinuity across time and space, though biological continuity is retained. The discontinuity in self and identity however, imply that the person with dementia changes considerably and so too may values and beliefs. A document which best reflected the wishes of the person with dementia in the past, may not always do so now. Advance directives and proxy representatives may need to be dynamic and evolve over time, particularly where end of life care and physician assisted death is being invoked.
Simulating Defensive Trajectories in American Football for Predicting League Average Defensive Movements
Authors: Schmid Marc , Blauberger Patrick , Lames Martin
Published: July 2021

American football is an appealing field of research for the use of information technology. While much effort is made to analyze the offensive team in recent years, reasoning about defensive behavior is an emergent topic. As defensive performance and positioning largely contribute to the overall success of the whole team, this study introduces a method to simulate defensive trajectories. The simulation is evaluated by comparing the movements in individual plays to a simulated league average behavior. A data-driven ghosting approach is proposed. Deep neural networks are trained with a multi-agent imitation learning approach, using the tracking data of players of a whole National Football League (NFL) regular season. To evaluate the quality of the predicted movements, a formation-based pass completion probability model is introduced. With the implementation of a learnable order invariant model, based on insights of molecular dynamical machine learning, the accuracy of the model is increased to 81%. The trained pass completion probability model is used to evaluate the ghosted trajectories and serves as a metric to compare the true trajectory to the ghosted ones. Additionally, the study evaluates the ghosting approach with respect to different optimization methods and dataset augmentation. It is shown that a multi-agent imitation learning approach trained with a dataset aggregation method outperforms baseline approaches on the dataset. This network and evaluation scheme presents a new method for teams, sports analysts, and sports scientists to evaluate defensive plays in American football and lays the foundation for more sophisticated data-driven simulation methods.
The Characteristics of Spike Glycoprotein Gene of Swine Acute Diarrhea Syndrome Coronavirus Strain CH/FJWT/2018 Isolated in China
Authors: Guo Yan-Yan , Wang Pei-Hua , Pan Yuan-Qing , Shi Rui-Zhu , Li Ya-Qian , Guo Fan , Xing Li
Published: July 2021

Swine acute diarrhea syndrome (SADS) is a highly contagious infectious disease characterized by acute vomiting and watery diarrhea in neonatal piglets. The causative agent for SADS is the swine acute diarrhea syndrome coronavirus (SADS-CoV), an alphacoronavirus in the family Coronaviridae. Currently, SADS-CoV was identified only in Guangdong and Fujian provinces of China, not in any other regions or countries in the world. To explore the genetic diversity of SADS-CoV isolates, herein we comparatively analyzed 44 full-length genomes of viruses isolated in Guangdong and Fujian provinces during 2017–2019. The spike glycoprotein gene of SADS-CoV strain CH/FJWT/2018 isolated in Fujian province is distinct from that of other viral isolates in either spike glycoprotein gene-based phylogenetic analysis or whole genome-based gene similarity analysis. Moreover, at least 7 predicted linear B cell epitopes in the spike glycoprotein of CH/FJWT/2018 would be affected by amino acid variations when compared with a representative virus isolated in Guangdong province. The spike glycoprotein of coronaviruses determines viral host range and tissue tropism during virus infection via specific interactions with the cellular receptor and also plays critical roles in eliciting the production of neutralizing antibodies. Since SADS-CoVs have a broad cell tropism, the results in this report further emphasize that the spike glycoprotein gene is a pivotal target in the surveillance of SADS-CoV.
Assessment of total bacterial diversity in whiteleg shrimps and its aquaculture environment in Pangkajene and Banyuwangi, Indonesia
Authors: Hastuti Yuni Puji , Fatma Yuli Siti , Pitoyo Hardi , Nurussalam Wildan , Ruhyana Jajang
Published: July 2021

Detection of bacterial diversity in whiteleg shrimps and its rearing water is a vital first step in monitoring aquaculture activities. Bacterial community imbalance in whiteleg shrimps and its rearing water influences the quality and quantity of shrimp production. Identifying the bacterial community provides basic information related to dominant bacterial groups in whiteleg shrimps and environments, providing recommendations for proper environmental monitoring and management. In this study, we investigated bacterial community structure in the rearing water and intestinal tract of whiteleg shrimp (Litopenaeus vannamei) collected from two sites, i.e., Pangkajene, South Sulawesi (SU) and Banyuwangi, East Java (BW), Indonesia. The bacterial community was analyzed using amplicon sequencing with Illumina sequencing platform based on the V3-V4 region of the 16S rRNA genes. Bacterial diversity and composition were found differed between the rearing water and the shrimps’ intestines. Bacterial diversity in the rearing water of Banyuwangi (W.BW) was higher than that of Pangkajene (W.SU). Proteobacteria, Bacteroidetes, and Firmicutes were found as the most dominant phyla in rearing water from both farms, while distinct bacterial composition was observed in the shrimps’ intestines. The shrimp intestine from Banyuwangi (U.BW) was dominated by Firmicutes (22.36%), Proteobacteria (22.33%), and Verrucomicrobia (21.11%). In contrast, the shrimp intestine from Pangkajene (U.SU) was highly dominated by Tenericutes (88.54%), followed by Proteobacteria (4.66%), and Firmicutes (2.27%). The difference in bacterial community structure between the rearing water and shrimps’ intestines suggested that the host intestinal environment might have greater selective pressure for bacterial composition inhabiting L.vannamei intestines. Our observations suggest that the shrimps cultured in the rearing water with the similar dominant bacterial group have specific intestinal bacterial diversity.
A New Multi-Target Compiler Architecture for Edge-Devices and Cloud Management
Authors: GÖKÇAY Erhan
Published: July 2021

Edge computing is the concept where the computation is handled at edge-devices. The transfer of the computation from servers to edge-devices will decrease the massive amount of data transfer generated by edge-devices. There are several efficient management tools for setup and connection purposes, but these management tools cannot provide a unified programming system from a single source code/project. Even though it is possible to control each device efficiently, a global view of the computation is missing in a programming project that includes several edge-devices for computation and data analysis purposes, and the devices need to be programmed individually. A generic workflow engine might automate part of the problem using standard interfaces and predefined objects running on edge-devices. Nevertheless, the approach fails in fine-tuning each edge-device since the computation cannot be moved easily among devices. This paper introduces a new compiler architecture to control and program edge-devices from a single source code. The source code can be distributed to multiple edge-devices using simple compiler directives, and the transfer and communication of the source code with multiple devices are handled transparently. Fine-tuning the source code and code movement between devices becomes very efficient in editing and time. The proposed architecture is a lightweight system with fine-tuned computation and distribution among devices.
Direct Displacement Based Design for Reinforced Concrete Framed Structures with Seismic Isolation
Authors: CHIKMATH Channabasaveshwar , SODHA Ankit , VASANWALA Sandip
Published: July 2021

Direct displacement-based design is a nonlinear static procedure and has to check the suitability of the method against different types of ground motions namely far field, near field forward directivity and near field fling step. The method is applied for the buildings supported on a fixed base and hysteretic isolation bearings. Seismic isolators are provided between the foundation and the superstructure to minimize the influence of ground motion on the superstructure. The method is applied for four, eight and twelve storey reinforced concrete frame structures equipped with and without seismic isolators. Lead rubber bearing is used as seismic isolators. An equivalent damping ratio, derived from the particular characteristics of buildings supported on isolation bearings, is suggested. The energy dissipation mechanism in the isolators controls the displacement of the structure within acceptable limits at the level of the isolator. The results were validated with nonlinear time history analysis and were found to be in good agreement with the Direct displacement-based design methodology for far field ground motions. The performance of the building was measured for interstorey drift ratio, time period, acceleration of top floor, base shear, isolator displacement. This is an attempt to link the direct displacement-based design of the reinforced concrete building with seismic isolators subjected to the far field, near field forward directivity, near field fling step ground motions.
Development of a Hybrid Radio Frequency Identification (RFID) and Biometric Based Library Management System
Authors: OKUBANJO Ayodeji , OKANDEJİ Alexander , OSİFEKO Ositola , ONASOTE Ayoola , OLAYEMİ Mufutau
Published: July 2021

This paper presents a smart library management system based on the combination of RFID technology and biometric recognition system to improve the efficiency of conventional library management. In particular, the proposed design combines radio frequency identification (RFID) and Biometric technology to enhance user processing time, improve user service, curtail book theft, and maintain continuous update of new books and to further increase the biometric security of the system against an imposter. Using MySQL, internet of things (IoT), and Java programming, we design a system that provides the user with unrestricted access to online library facilities with a personal computer or mobile devices. For improved efficiency, the proposed design is integrated with an SMS and email alert notification system. The proposed design thus allows the user to access books and course materials from a remote location in an authenticated and secured manner. The system performance was compared with the manual method in terms of book positioning function, false rejection rate, false acceptance rate, counting efficiency, average time spent in booking searching and the result show that the proposed system outperforms the conventional (manual) library system
An Efficient Hybrid Algorithm with Particle Swarm Optimization and Nelder-Mead Algorithm for Parameter Estimation of Nonlinear Regression Modeling
Authors: YONAR Aynur , YONAR Harun
Published: July 2021

Nonlinear regression analysis is an important statistical method widely used in many fields of science to model the complex relationships between variables. Therefore, many studies have been conducted to estimate the parameters of nonlinear regression models using various iterative techniques. In this study, an efficient hybrid algorithm, namely PSONM, by combining the exploration capability of Particle Swarm Optimization (PSO) and the exploitation capability of the Nelder-Mead (NM) algorithm is proposed to obtain parameter estimates of nonlinear regression models. To show the performance of the proposed hybrid algorithm, 20 nonlinear regression tasks with various levels of difficulty, and real data sets in the agriculture field have been tested. The experimental results indicated that the suggested hybrid algorithm provides accurate estimates, and its performance is much superior to those of NM and PSO algorithms.
Investigation of Microwave Drying of a Firefighting Hose
Authors: DAĞLI Merve , ÇELEN Soner
Published: July 2021

The hoses used for fire extinguishing must be dried and stored after use in order to be cleaned, maintained and long-lasting. For this purpose, microwave energy which is a fast drying technology, was applied at power values of 2450 MHz and 120 W, 350 W and 460 W. The aim here is to dry the hoses quickly and show the effect of microwave energy by looking at SEM images and taking thermal photographs. In addition to it, nine drying models were compared with each other in order to determine the moisture content of the hose. The performances of these models were compared according to the correlation coefficient value (r), the estimated standard error (es) and the sum of squares of the residuals (χ2). According to the results, it was determined that the Logarithmic model for all drying conditions explains the drying behavior of the products better than the others. In addition, the effect of microwave drying did not cause a change on the internal structure of the sample but in consequence of thermal analysis, a fast rising was observed in the sample’s temperature with the energy rise.
El ciclo de la lana: exportación, campesinos y conflicto social en Puno de 1850 a 1930
Authors: Carcelén Carlos Guillermo , Morán Ramos Luis Daniel
Published: July 2021

The export of wool was for a long time, for the south of Peru the main activity, since with the objective of exporting, the production, the market and the marketing mechanisms of wool, both alpaca and sheep, were organized. With this, giving rise to the formation of a society in which the production and commercialization of wool will create and recreate the characteristics of life and social relations in a geographical space that is important due to its extension. This activity will present various conflicts between the direct producers that were the peasant communities, the traders and the landowners, both for the possession of the land or the control of the regional commercial networks to supply the international demand.
Laparoscopía de etapificacíon y citología peritoneal en cáncer gástrico. Descripción de la técnica y revisión de la literatura
Authors: Venturelli Muñoz Francisco José , ESPERGUEL GALAZ CARLOS RENATO , Zambrano Velásquez Jesús Enrique , FERNANDEZ MARAMBIO BENJAMIN ADOLFO
Published: July 2021

Introducción: El cáncer gástrico continúa representando la más alta mortalidad por cáncer en hombres en Chile. En una revisión sistemática, evidenciaron que el 59% de los pacientes que se catalogaron como M0 mediante diferentes estudios como TC, resonancia magnética y PET, se detectaron metástasis a la laparoscopia de etapificación. El objetivo de este estudio es describir la técnica quirúrgica de esta laparoscopía incluida la citología peritoneal y una revisión de la literatura en cuanto a sus indicaciones y posibilidad de cambio de conducta.Materiales y Método: se realizó la búsqueda de artículos vía MEDLINE/PubMed (U.S.A. National Library of Medicine), Cochrane Library, Elsevier, SciELO; no se aplicó análisis estadístico, se incluyeron 23 referencias relacionadas al tema y materias afines internacionales y nacionales. El procedimiento que describir será la laparoscopia diagnostica y la citología de líquido peritoneal para estudio anatomopatológico.Discusión y conclusión: La laparoscopía de etapificación, logra un cambio de conducta en un 20% aproximadamente de los casos, pero hacen faltan más estudios de validación de esta en los centros que tratan dicha enfermedad en el país.
TERAPIA ASISTIDA CON VACÍO Y ESTOMA FLOTANTE (FLOATING STOMA). UNA NUEVA FORMA DE TRATAR UN ABSCESO PERIOSTOMAL.
Authors: Vergara Gomez Arturo , Cadena Gutierrez Manuel Enrique , Cabrera Vargas Luis Felipe , Pedraza Ciro Mauricio
Published: July 2021

Introducción: Los estomas flotantes se definen como un estoma que no esta fijado a la piel de la pared abdominal, esta técnica se ha descrito en cirugía para fistulas entero atmosféricas y de control de daños.Caso Clínico: Presentamos un reporte de caso de manejo de absceso paraostomal en paciente con antecedente de laparotomía por abdomen agudo, por lo que se decide uso de terapia de presión negativa asociada a estoma flotante, demostrando su utilidad en este tipo complejo de pacientes.
PROTOTYPING OF BUKHARA CULINARY APPLICATION
Authors: Tukhtayev Umidjon , Hanum Yuhilza
Published: July 2021

The purpose of this research is to build a prototype of Bukhara Culinary Application using informal prototyping method. The difference between this application and the existing ones is the availability of ingredients and history information. This application will also provide delivery service to the customers. Customers and drivers register to this application, so that their details will be recorded. This might not seem much different from the available applications, but this research is also conducted to portray the use of informal prototyping. It is used for the ease in accommodating changes and continuing to the next step of software development by using commonly used software such as Adobe Photoshop. This research resulted in a prototype that provide the described information for 17 dishes from 5 restaurants in Bukhara.
BIOAKTIVITAS JAMUR Aspergillus flavus YANG BERSIMBION DENGAN ASCIDIAN Eudistoma sp.
Authors: Mongi Alfa , Sumilat Deiske A , Losung Fitje , Mangindaan Remmy E P , Lintang Rosita A , Undap Suzanne L
Published: July 2021

Ascidian is a marine invertebrate that produce bioactive compounds such as antibacterial and antifungal. The purpose of this study was to obtain symbiotic fungi isolates, ethyl acetate extracts from ascidian symbiotic isolates, and to determine the antibacterial and antifungal activities of ethyl acetate extracts of symbiotic isolates using the diffusion method (disc diffusion Kirby and Bauer) against Escherichia coli, Staphylococcus aureus bacteria and against the Candida albicans fungus. The results obtained 1 ascidian species which was cultured to obtain pure isolates, the pure isolates were tested molecularly and the results showed that the isolate was Aspergillus flavus, then the isolates were grown on rice medium and extracted. The results of the fungal extract showed the presence of antibacterial and antifungal activity against Escherichia coli by 10 mm, Staphylococcus aureus by 19 mm and against the Candida albicans by 13.5 mm. Keywords : Ascidian, Eudistoma sp., Aspergillus flavus, Antibacterial, Antifungal, Symbiotic.                                                  AbstrakAscidian merupakan avertebrata laut yang dapat menghasilkan senyawa bioaktif yang seperti antibakteri dan antijamur. Tujuan dari penelitian ini yaitu mendapatkan isolat jamur simbion dari ascidian, mendapatkan ekstrak etil asetat dari isolat jamur simbion ascidian, dan menguji aktivitas antibakteri dan antijamur ekstrak etil asetat isolat jamur simbion dengan metode difusi agar (disc diffusion Kirby and Bauer) terhadap bakteri Escherichia coli, Staphylococcus aureus dan terhadap jamur Candida albicsans. Hasil penelitian didapatkan 1 jenis ascidian yang kemudian dikultur untuk mendapatkan isolat murni, isolat murni diuji secara molekuler dan didapati hasil bahwa isolat tersebut merupakan jamur Aspergillus flavus. Isolat tersebut kemudian ditumbuhkan pada media nasi dan diekstrak. Hasil ekstrak jamur tersebut menunjukkan adanya aktivitas antibakteri dan antijamur terhadap bakteri Escherichia coli sebesar 10 mm, Staphylococcus aureus sebesar 19 mm dan terhadap jamur Candida albicsans 13,5 mm. Kata kunci : Ascidian, Eudistoma sp., Aspergillus flavus, Antibakteri, Antijamur, Simbion.
ISOLASI BAKTERI YANG BERSIMBION DENGAN ASCIDIAN Herdmania momus YANG MEMILIKI AKTIVITAS ANTIBAKTERI
Authors: Koyongian Silvia E , Sumilat Deiske A , Lintang Rosita A J , Wullur Stenly , Tilaar Sandra O , Pangkey Henneke
Published: July 2021

Ascidian is marine invertebrates in coral reef ecosystems that produce many bioactive compounds for pharmacology. The presence of symbiotic bacteria with marine organisms is protected the host biota by producing secondary metabolites. The purpose of this study is to obtain symbiotic bacterial isolates with Herdmania momus ascidian, then to observe the antibacterial activity of these bacterial isolates against Escherichia coli, and Staphylococcus aureus. Isolation and culture of the symbiotic bacteria were made on Nutrient Agar and Zobell Marine Broth media. The antibacterial screening showed that the Herdmania momus symbiotic bacteria were able to inhibit the growth of Staphylococcus aureus and Escherichia coli.Keywords: ascidians, Herdmania momus, bacteria, isolation, antibacterialAbstak          Ascidian adalah avetebrata laut di ekosistem terumbu karang yang banyak menghasilkan senyawa bioaktif untuk bidang farmakologi. Keberadaan bakteri yang bersimbion dengan organisme laut pada umumnya untuk melindungi biota yang ditumpanginya dan dirinya dengan cara menghasilkan senyawa metabolit sekunder. Tujuan dari penelitian ini yaitu untuk mendapatkan isolat bakteri yang bersimbion dengan ascidian Herdmania momus, kemudian mengamati aktivitas antibakteri dari isolat bakteri tersebut terhadap Escherichia coli, dan Staphylococcus aureus. Isolasi dan kultur bakteri yang bersimbion dengan ascidian dibuat pada media Nutrient Agar dan Zobell Marine Broth. Skrining aktivitas antibakteri menunjukkan isolat bakteri yang bersimbion dengan ascidian Herdmania momus mampu menghambat pertumbuhan organisme uji Staphylococcus aureus dan Escherichia coli.Kata kunci: ascidian, Herdmania momus, bakteri, isolasi, antibakteri
ISOLASI DAN SKRINING AKTIVITAS ANTIBAKTERI DARI BAKTERI SIMBION NUDIBRANCHIA Phyllidiella pustulosa dan Thuridilla lineolata
Authors: Arie Ade Kurniawan , Lintang Rosita A J , Mangindaan Remy E P , Windarto Agung B , Losung Fitje , Longdong Sammy N J
Published: July 2021

Nudibranchs are marine invetebrates belongs to the class of Gastropoda that are able to camouflage and develop a self-defense systems. Marine bacteria contain chemicals compunds that have potentials on marine drugs discovery through the secondary metabolism. The purpose of this study was to isolate the symbiotic bacteria from nudibranches Phylidiella pustulosa and Thuridilla lineolate and to screen the antibacterial activity of these bacterial isolates against Escherichia coli and Staphylococcus aureus. Isolation and culture of the symbiotic bacteria was made on B1 (solid) media. The results of the antibacterial assay showed that the symbiotic bacterial isolates from Phylidiella pustulosa and Thuridilla lineolate were able to inhibit the growth of the Staphylococcus aureus and Escherichia coli test. Keywords: nudibranch, Phyllidiella pustulosa, Thuridilla lineolate, bacteria, antibacterialAbstrakNudibranch adalah avetebrata laut dalam kelas Gastropoda yang mampu melakukan kamuflase dan mengembangkan sistem pertahanan diri. Bakteri laut mengandung senyawa kimia yang berpotensi sebagai bahan obat-obatan yang dihasilkan melalui metabolit sekunder. Tujuan dari penelitian ini yaitu untuk mengisolasi bakteri yang bersimbion dengan nudibranch Phylidiella pustulosa dan Thuridilla lineolate, kemudian mengamati aktivitas antibakteri dari isolat bakteri tersebut terhadap Escherichia coli danStaphylococcus aureus. Isolasi dan kultur bakteri yang bersimbion dibuat pada media B1 (padat). Skrining aktivitas antibakteri menunjukkan isolat bakteri yang bersimbion dengan nudibranch Phylidiella pustulosa dan Thuridilla lineolate mampu menghambat pertumbuhan organisme uji Staphylococcus aureus dan Escherichia coli. Kata kunci: nudibranch, Phyllidiella pustulosa, Thuridilla lineolate, bakteri, antibakteri
STRUKTUR KOMUNITAS MANGROVE DI DESA LESAH, KECAMATAN TAGULANDANG, KABUPATEN SITARO
Authors: Asman Indra , Sondak Calvyn F A , Schaduw Joshian N W , Kumampung Deislie R H , Ompi Medy , Sambali Haryani
Published: July 2021

Mangroves are forests that grow in brackish water and are affected by tides and seawater, and these forests grow specifically in places where there are pavement and accumulation of organic material. The purpose of this research is to identify the types of mangroves and determine the structure of the mangrove community in Lesah Village. This research was conducted from September to October 2019. The method used in this research is the quadrant line transect method. The types of mangroves were identified with identification books. Community structure data taken are density, frequency, dominance and important value index (IVI) and then analyzed with Microsoft Excel program. Based on the results of the research, there are 2 types of mangroves found in the research location, Rhizophora stylosa and Sonneratia alba. The highest density value (0.122 ind / m2), relative density (81.88%), frequency types (1), relative frequency (50%). Closure types (1.83 m2), types of relative closure (50.18%), the highest important value index at the research site was (182.12%). The results of the mangrove ecological index data analysis for the diversity index value (0.51), dominance (0.73). Keywords: Structure Community, Mangrove, Lesah Village. Abstrak Mangrove adalah hutan yang tumbuh di air payau, dan dipengaruhi oleh pasang surut air laut dan hutan ini tumbuh khususnya di tempat-tempat di mana terjadi pelumpuaran dan akumulasi bahan oraganik. Tujuan dari penelitian adalah mengidentifikasi jenis-jenis mangrove dan mengetahui struktur komunitas mangrove di Desa Lesah. Penelitian dilaksanakan dari September-Oktober 2019. Metode yang digunakan adalah metode line transek kuadran. Jenis-jenis mangrove di identifikasi dengan bantuan buku identifikasi. Data struktur komunitas yang di ambil adalah kerepatan, ferkuensi, dominasi dan indeks nilai penting(INP) dan kemudian di analisa dengan bantuan program computer Microsoft Excel. Berdasarkan hasil penelitian terdapat 2 jenis mangrove yang terdiri dari, Rhizophora stylosa dan Sonneratia alba. Nilai kerepatan tertinggi (0.122 ind/m2), kerapatan relatif jenis (81.88%), frekuensi jenis (1), frekuensi relatif jenis (50%). Penutupan jenis (1.83 m2), penutupan relatif jenis (50.18%), indeks nilai penting tertinggi dilokasi penelitian adalah (182.12%). Hasil analisis data indeks ekologi mangrove untuk nilai indeks keanekaragaman (0.51), dominasi(0.73). Kata Kunci: Struktur Komunitas, Mangrove, Desa Lesah.
UJI AKTIVITAS ANTIBAKTERI DAN ANTI-UV Phyllidiella nigra DAN BAKTERI SIMBIOTIKNYA DARI PERAIRAN TANJUNG MANDOLANG
Authors: Dajoh Tessalonica , Bara Robert A , Angkouw Esther , Ompi Medy , Lintang Rosita A , Lumenta Cykca
Published: July 2021

Phyllidiella nigra is an organism that is suspected to have secondary metabolites because their ability to develop its self defense system by camouflage and using chemical compounds derived from their nature diet as deterrent against their predators. The purpose of this study was to isolate symbiotic bacterial derived from P. nigra, extracted and followed by, the antibacterial assays against Escherichia coli and Bacillus megaterium as well as the anti-UV assay. The results showed that the five isolates tested had an antibacterial activity with the highest average inhibition zone against E. coli DSM 498 bacteria, isolate 1 (14.67 mm), isolate 5 (14 mm), and against B. Megaterium DSM 32T bacteria, isolate 3 (13.33 mm). The three isolates which had the highest inhibition zone and P. nigra extract were tested for anti-UV assay using a UV-Vis Spectrophotometer. The results obtained isolate 3 has absorption of UV-A with the UV absorbtion maximum at λ 340 nm and P. nigra extract has absorption on UV-B radiation with UV absorption maximum at λ 290 nm. Key words: Nudibranchia, Bacteria, Anti-bacteial, Anti-UV Phyllidiella nigra merupakan organisme yang diduga memiliki metabolit sekunder karena mampu mengembangkan sistem pertahanan dirinya dengan cara kamuflase dan menggunakan senyawa kimia sebagai racun yang didapat dari makanannya. Tujuan dari penelitian ini yaitu mendapatkan isolat bakteri yang bersimbiosis dengan P. nigra, mendapatkan ekstrak dari baktri simbion, dan menguji antibakteri dan anti-UV ekstrak etil aseta bakteri simbion dengan metode difusi agar terhadap bakteri Escherichia coli dan Bacillus megaterium. Hasil penelitian didapatkan kelima isolat yang diuji memiliki aktivitas antibakteri dengan rerata zona hambat tertinggi terhadap bakteri E. coli DSM 498 yaitu isolat 1 (14,67 mm), isolat 5 (14 mm), dan terhadap baktri B. megaterium DSM 32T yaitu isolat 3 (13,33 mm). Ketiga isolat yang memiliki zona hambat tertinggi dan ekstrak P. nigra diujikan anti-UV menggunakan alat UV-Vis Spektrofotometer. Hasil yang didapat isolat 3 memiliki serapan terhadap radiasi sinar UV-A dengan puncak tertinggi pada λ 340 nm dan ekstrak P. nigra memiliki serapan terhadap radiasi sinar UV-B dengan puncak tertinggi berada pada λ 290 nm. Kata kunci: Nudibranchia, Bacteria, Anti-bacteial, Anti-UV