bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas Chromatography Tandem Mass Spectrometry for Quantitative Analysis of Pesticides in Sitopaladi Churna: Multi-Residue Method Development
Authors: Jaiswal Ravi Prakash , Azam Akbare , Rafi Najm Ul , Nirala Hemant Kumar , Sonkar Sankatha Prasad , Dwivedi Dr. Bandana , Srivastav Dr. Mudit Prakash , Ahmed Dr. Rubi , Pandey Dr. Ashok Kumar
Published: May 2024

Pesticide residues are a consistent concern for consumers. A method validation study was conducted to analyze pesticide residues in Sitopaladi Churna using gas chromatography tandem mass spectrometry (GC-MS/MS) in a multiple reaction monitoring (MRM) mode of electron impact (EI) determination. The method employed the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) approach in compliance with European SANTE standards. Results fell within the specified criteria outlined in the validation guidelines. Validation parameters were assessed to confirm the method's suitability for the intended analysis. The optimized method was applied to detect residues of 55 pesticides in the herbal formulation 'Sitopaladi Churna,' with maximum residue limits (MRLs) defined in the Ayurvedic Pharmacopoeia of India (API). Notably, the method demonstrated high effectiveness, providing accurate results (70–120.0%) with precision (<20%) at three concentrations (10 μg/kg, 25 μg/kg, and 100 μg/kg). Limits of quantification (LOQs) were 5 μg/kg, and limits of detection (LODs) were 2 μg/kg. The analysis exhibited strong linearity with a regression coefficient exceeding 0.99 for all compounds. Consequently, this method can be employed for the determination of 55 pesticides in Sitopaladi Churna, as well as similar matrices, to analyze pesticide residues.
The Bronze Age Site of Tarangul (Aktobe Cis-Urals): Examining One Casting Mold
Authors: Baitileu Darkhan , Yerzhanova Albina , Calgaro Ilaria
Published: May 2024

Introduction. In 2021, the Mugodzhar (Mugalzhar) Crew of the Margulan Institute of Archaeology investigated the site of Tarangul and discovered a casting mold ― a rare artifact of utmost interest related to metal production and processing. Goals. The article seeks to describe and analyze the Bronze Age mold from Tarangul located in the Aktobe Cis-Urals, introduce into scholarly circulation some newly obtained scientific data. Results. The implemented analyses include those of natural science (micro-wear and spectral ones) and comparative typology, the latter to yield a classification of castings and their cultural affiliation. The tool mold has two surfaces with negative impressions. The first one was used to cast three sickles, while the second one (once consisted of two pieces) would cast a flat adze. The shapes attest to the mold was used to cast Kundravinskaya-type sickles widespread across the Late Bronze Age Southern Urals, Middle Volga, and Western Siberia. Kundravinskaya-type sickles are associated with the Alakul culture, the Kozhumberdy cultural group being a local variant of the latter in the region under study. The shape of the impression on the reverse side is characteristic of adzes from the Alakul era discovered in western parts of Eurasia’s steppe zone. The study concludes the mold had first consisted of two pieces and been used to cast adzes, and after the other piece was lost or damaged it started being used to cast sickles. The spectral analysis shows the castings were basically made from copper, and detects some traces of alloying. Another finding is that the three mold negatives were used not simultaneously but rather when and as it was necessary. In general, the conducted tests have well reconstructed the manufacturing techniques and stages of use for the mold from the Late Bronze Age settlement of Tarangul in the Aktobe Cis-Urals, and highlighted certain aspects in the study of molds as a specific source on metal production techniques and technologies in prehistory.
Ayuka’s Title of Daichin Khan: Examining Tibetan-Language Sources
Authors: Mitruev Bembya
Published: May 2024

Introduction. Data from Tibetan-language sources on Ayuka’s full title ― Daichin Khan Ayuka ― have never been introduced into scientific circulation, nor have those been subject to any essential analysis. Goals. So, the article introduces a variety of messages dealing with the ruling era of Khan Ayuka and narrating how the latter received the title of Daichin Khan from the then Dalai Lama. Materials. The paper investigates Tibetan-language biographies of the Fifth Dalai Lama Lobsang Gyatso, Sixth Dalai Lama Tsangyang Gyatso, and Fifth Panchen Lama Lobsang Yeshe. Results. The study figures out the date when the mentioned ruler did receive the title of Daichin Khan, and specifies the dates of embassies that delivered the Kalachakra seal and that of Khan from the Sixth Dalai Lama. Conclusions. The article examines materials contained in various Tibetan-language texts, such as the autobiography of the Great Fifth Dalai Lama and that composed by Desi Sangye Gyatso, biography of Fifth Panchen Lama, etc. The work ascertains the ruler of the Kalmyk Khanate received the title of Daichin Khan Ayuka from the Sixth Dalai Lama Tsangyang Gyatso in 1697. The paper also reveals some data on Khan Ayuka’s embassy to Tibet led by Arabjur and on the latter’s mother Tsojal. Another newly identified and important historical fact is that the Dalai Lama did send an embassy to Khan Ayuka to deliver a secret message about the Great Fifth’s death.
Astrology as Sacred Ecological Knowledge in the Tibetan Buddhist Tradition
Authors: Erendzhenova Yulia
Published: May 2024

Introduction. The identification of specific responses generated by religious traditions to present-day global challenges actualizes the rethinking of astrology as a traditional understanding of the world structure and influence of natural forces on man in Tibetan Buddhism. Goals. The study attempts an evaluation of astrology as a form of sacred knowledge in the Tibetan Buddhist tradition from the perspective of understanding its principles of ecology. Materials and methods. To facilitate this, the work employs a systematic approach of cultural anthropology according to which sacred astrological knowledge is viewed as an integral element to the specified religious tradition. The paper focuses on The White Beryl: A Treatise on [Tibetan] Astrology by Desi Sangye Gyatso, as well as works by modern Tibetan astrologers. Results. Tibetan astrology arose from integrated Indian, Chinese and ancient Tibetan ideas about the influence of natural elements on human life, and is a required tool in Tibetan medicine. Those ideas are based on some esoteric premises of the Buddhist Kalachakra Tantra which articulates the relationship between external natural cycles and internal human energy ones, as well as suggests methods of restoring the latter’s balance. In the Tibetan Buddhist tradition, sacred astrological knowledge is widely popular both in cult practices and non-religious activities. Astrologers draw prediction and natal charts, calculate favorable periods for rituals, healing practices, harvesting, weddings, funerals, etc. The three Lamrim-derived motives — to improve this lifetime, gain liberation from samsaric suffering, achieve enlightenment for the sake of universal well-being — may accordingly direct the intentions of Buddhists toward the use of sacred astrological knowledge to solve problematic situations, identify oneself, understand others, restore the balance of external and internal cycles. With due account of that followers of Tibetan Buddhism are basically oriented to altruism and rationalism, the paper presumes astrology can be considered a form of sacred knowledge instrumental in understanding (and implementing) principles of ecology. Restoration of balance in man-nature interaction through the rational use of astrological knowledge for the common good predetermines the sacredness of ecological knowledge in the Tibetan Buddhist tradition.
The Shaping of New Ethnic Clusters in Kalmykia, 1957–1991
Authors: Belousov Sergey
Published: May 2024

Introduction. The article discusses the shaping of largest ethnic clusters (besides those of Kalmyks and Russians proper) across the Kalmyk ASSR in 1957–1991. The process is of certain scientific and practical interest, since it may extend our knowledge of how ethnic structures in Russia would take shape, including in the particular region of Kalmykia. Goals. The article aims at outlining the specified process in the territory of the Kalmyk ASSR at the final stage of the Soviet era. The study employs the historical/comparative and historical/genetic methods to examine materials from the National Archive of Kalmykia, published documents and statistical tables, republican newspaper articles. Results. The work investigates some circumstances behind the emergence of new ethnic clusters, shows their population dynamics, types and forms of resettlement, analyzes official policies and interethnic relations between locals and migrants. The present-day ethnic structure of Kalmykia started taking shape after the Kalmyk people’s autonomy was restored in 1957. The Government invested considerable funds to reconstruct and develop the Kalmyk ASSR but the available labor resources of Kalmyk homecomers and Russian natives were insufficient. So, the authorities were forced to recruit laborers in other regions. Stable new ethnic communities emerged in rural areas, the majority of the migrants having arrived from neighboring North Caucasian republics then characterized by intense population growth and excess labor resources. Shortly before the collapse of the Soviet Union, urgently evacuated Meskhetian Turks and Kurds were also resettled to the republic. Conclusions. The emergence of new ethnic clusters in the Kalmyk ASSR was facilitated by the Government’s large investments that resulted in increased jobs unable to be filled by homecomers and locals. There were no special ethnic resettlement projects but the granted employment opportunities in the reestablished republic were attractive enough, which led to a migration surge and the shaping of new ethnic communities.
The Late 1980s HIV Outbreak in the Southeast of Soviet Russia: Soviet Government and Its Policy against the Epidemic (The Case of Kalmykia)
Authors: Baduginova Margarita
Published: May 2024

Introduction. The study provides a first insight into the official Soviet policy and anti-HIV nationwide arrangements (1985–1990), and reviews the 1988–1989 HIV outbreak in the southeast of the RSFSR. The paper’s chronological framework covers the era of dramatic political and socioeconomic changes and restructuring endeavors commonly referred to as ‘perestroika’. Goals. The study attempts a comprehensive analysis to identify some features of the policy pursued by Soviet executives and healthcare agencies in the face of the emerging HIV threat throughout the mid-to-late 1980s. The work focuses on the activities of government institutions, certain measures, preventive and anti-epidemic arrangements, as well as the efforts of a special commission for organizational and practical assistance to Soviet Kalmykia’s Ministry of Health. Materials and methods. The study rests on the fundamental principles of systemacity, objectivity, historicism and complexity that have proved instrumental in analyzing documentary sources and comparing the obtained materials; describing the development and changes in official HIV-related policy; examining social, political and economic shifts across the regions under consideration as integral to what was being experienced nationwide; articulating objective evaluations of the Soviet government’s policy pertaining to the epidemic. The article primarily investigates a variety of newly discovered documents from the National Archive of Kalmykia and State Archive of the Russian Federation. Results. The arrived HIV served an indicator that would test the strength of Soviet healthcare system, and the latter — like the whole country — was not ready to fight the ‘plague of the twentieth century’. The adopted anti-epidemic policy proved inefficient. Meanwhile, the limited access to research, established practices of secrecy, and incompetence of the country’s leadership had negative impacts on the struggle against the dangerous disease. The then changes did negatively affect such an important social sphere as healthcare, which led to a severe decline of what once had been a leading public health system of the world.
A reparação do dano como condição do acordo de não persecução penal nos crimes contra a ordem tributária
Authors: Araújo Rebouças Sérgio Bruno , Barros de Siqueira Ana Beatriz
Published: May 2024

This article problematizes the reparation of damage as a condition of the non-prosecution agreement (NPA) in crimes against Brazilian tax system. The applicability of this condition is addressed in crimes where the full reparation of the damage (payment of the tax) already has the effect of extinguishing criminal liability. This research is intended to answer the following problems: (i) Is the NPA applicable in tax crimes? (ii) Must the reparation of the damage, as a condition of the NPA, cover the full value of the tax, including interests and fines? (iii) Is the reparation of the damage always necessary to sign a NPA? The expectation of advantage to the accused, provided by the agreement as a negotiated justice instrument, is considered as a condition of its own meaning and effectiveness. On the other hand, the expectation of protection of the legal interest is considered in light of the sufficiency of the agreement as an instrument of prevention and repression of tax crimes. Possible ways of reconciling these expectations are delimited as hypotheses, through solutions such as a restricted understanding of the reparation of damage and the viability of partial reparation. The research is qualitative, exploratory, and propositional, based on the analysis of specialized legislation and literature.
O juiz, as partes e as provas no sistema de julgamento penal italiano: contributo à reforma no Brasil
Authors: Bronzo Pasquale , Cunha Souza Bruno
Published: May 2024

With the judgment of ADIs nº. 6,298, 6,299, 6,300 and 6,305, by the STF’s Plenary, a clear resistance was expressed to a criminal process marked by accusatory characteristics in Brazil. Given the historical-legislative affinity of the Brazilian criminal process with Italy and the fact that the reform to the Italian accusatory model presented issues similar to those raised in the aforementioned judgment, gains relevance understanding how the judge, the parties and the evidence articulate themselves on the current Italian model. To this end, through the analysis of the Italian positive law faced with doctrinal perspectives on the pertinent topics, the relationships between the organization of the proof initiative and dispositive principle, “double acts”, free conviction of the judge, impartiality of the judge, procedural contradiction and agreements on the content of the procedural records are described.
Only Child Male and their Perception Towards Romantic Relationship and Gender Roles
Authors: P A Yasmin
Published: May 2024

Abstract: The purpose of this study is to provide a thorough understanding of the attitudes and experiences of only child men by examining their opinions of romantic relationships and gender roles. Due to the lack of siblings, the historical concept of "only child syndrome" has perpetuated unfavourable perceptions about only children, implying possible social skill impairments or selfish behaviour (Falbo & Polit, 1986). Modern research, however, contradicts these theories, showing that only children frequently perform comparably to siblings and, in specific situations, even outperform them in particular areas (Falbo & Polit, 1986). This study (Braithwaite & Holt-Lunstad, 2017) offers a nuanced perspective among only child guys, who value equality, partnership, and mutual respect in their romantic relationships through qualitative interviews and thematic analysis. They stress how important it is to spend time together, give back to the community, and engage in similar interests in order to promote emotional closeness and fulfilment (Falbo & Polit, 1986). Additionally, participants advocate for flexibility and shared responsibility in partnerships, rejecting established gender norms (Bukowski et al., 1987). Good communication techniques, such having candid conversations and paying attention, become essential instruments for resolving disputes and preserving harmonious relationships (Furman & Shaffer, 2003). These findings contribute to a deeper understanding of contemporary relationship dynamics by challenging stereotypes and providing insights into building fulfilling and healthy partnerships among male only children (Bukowski et al., 1987).
Deepfake, Disinformation and Social Media
Authors: Bhatta Sushant
Published: May 2024

Abstract: The advancement of Artificial Intelligence (AI) has uplifted the era of new possibilities. Along with the limelight positive aspects, there are some neglected negative aspects as well. With growing stardom, popularity and the need for power, AI and deep fakes have seen tremendous growth. Challenging the notions of privacy, identity and consent, AI clones and deepfake technology overshadow the reality and authenticity, producing fakely-realistic audiovisual contents. This paper deals with the impacts of AI clones and deepfaces, and lists out the possible solutions to reduce their impact.
Review on Repair and Rehabilitation of Cold Storage
Authors: Varghese Dr. V. P. , Ghaiwat Sharwani , Yerpude Harshal , Ghugal Payal , Patil Harsh , Kolhe Ashlesha
Published: May 2024

Abstract: The purpose of the project is to gain fundamental and practical understanding on concrete repair and rehabilitation of the structures. Large number of reinforced concrete (RC) structure are deteriorating, often prematurely, and need remedial measures to reinstate their safety and/or serviceability. Consequently, the need for repair and protection has grown considerably in recent years. While costs associated with repair of deteriorating concrete structures can be substantial, costs resulting from poorly designed or executed repairs may be even higher. Repair methods need to be designed with consideration for the anticipated or desired remaining service life of the structure. A distinction must be made between repairs intended to stop deterioration fully and those merely aimed at slowing down deterioration processes for a limited period of time. Then the respective repairs will be studied and classified into cracks, corrosion of concrete reinforcement, seepage and deterioration of surface coating. Detailed study will be done on the causes for each repair and a suitable rehabilitation method will be suggested for each repair site by comparing various methods. This paper presents review of literature available on the repair and rehabilitation of cold storage and presented a complied review report.
Integrated Fire Detection System using ML and IOT
Authors: Sawant Swapnil
Published: May 2024

Abstract: An integrated fire detection system that combines smoke, thermal, and image analysis using machine learning can provide real-time fire detection and reduce false alarms, thereby enhancing safety. Traditional single-sensor fire detection systems that rely on smoke or heat often result in false alarms or delays. The proposed multi-model system involves combining smoke, thermal, and YOLO v8 image detection technologies. However, challenges such as data privacy, cost, and maintenance need to be addressed. Nevertheless, this advanced fire detection system has the potential to significantly improve fire protection.
Vehicle Anti-Theft System Using Fingerprint & Passcode with Speed Control and Obstacle Detection
Authors: Mehta Shivesh
Published: May 2024

Abstract: This review paper explores the integration of a comprehensive vehicle anti-theft system, combining fingerprint and passcode authentication with speed control and obstacle detection. The rising concern of vehicle hijacking and theft emphasizes the need for enhanced security measures within the automotive industry. Leveraging biometric systems, known for their effectiveness in diverse applications, proves to be a promising solution. Biometric systems utilize unique biological traits to identify individuals, employing algorithms to ensure accurate user identification. In this suggested system, the signals produced by the Arduino Uno are directed to the relevant circuit within the module. Simultaneously, paper delves into the crucial relationship between security and performance monitoring in vehicles, emphasizing the significance of the speedometer as a vital component. Furthermore, the study advocates for the development of a cost-effective obstacle avoidance system applicable to both robots and automobiles, aiming to prevent accidents and minimize damage. This comprehensive approach combines advanced security, performance monitoring, and obstacle detection, offering a multifaceted solution to mitigate the risks associated with vehicle theft and enhance overall safety in the automotive realm.
Cyber Chatter
Authors: Gupta Aanvi , Mishra Abhishek , Srivastava Khushi
Published: May 2024

Abstract: Cyber Chatter, a web-based application built on the MERN stack, uses the power of GPT (Generative Pre-trained Transformer) technology to provide basic educational chat services and staff Building and ensure efficiency and they have been able to do it well. Cyber Chatter uses GPT-3.5, an advanced generic bid process, to provide accurate and meaningful answers to customer questions. With prior training in a large body of content knowledge, this demonstration demonstrates the incredible ability to develop and generate human-like emotions The application uses machine learning techniques to analyze customer data and continues to improve response quality over time. The use of Cyber Chatter has expanded to include Content Summarizer, Section Generator, Chat with Chatbot, Sci-fi image generator. Understudies can post questions, get answers, and engage in interesting conversations by using its natural user interface with GPT -a chatbot, Cyber Chatter. Cyber Chatter not only covers educational topics but also includes such features as content generators and JavaScript converters. Combining innovative features and an easy-to-use system, Cyber Chatter turns into a versatile punch where students can explore educational tools and interact with intelligent chatbots on a regular basis has enriched their learning experience
Optimizing MEP Design in Pharmaceutical Cleanroom with the Integration of 2D To 7D in BIM
Authors: Khandelwal Dr. Kirti
Published: May 2024

Abstract: This paper examines the optimization of pharmaceutical cleanroom design using 2D to 7D Modelling in Building Information Modelling (BIM). The goal is to enhance the reliability, different methods, statistical data, and performance of pharmaceutical production plants by effectively allocating components within design constraints. Mathematical optimization techniques improve facility design, ensuring robustness and operational efficiency. The study proposes a reliable optimal design for air-conditioning systems in pharmaceutical cleanrooms, considering uncertainties in design parameters and operational strategies. Resilient cleanroom systems are developed, and adaptable to various conditions while maintaining high performance standards. Additionally, the research explores the application of experimental design methodologies in optimizing drug delivery systems, such as factorial and etc, to enhance the quality and efficiency of pharmaceutical products and processes.
Traffic Sign Recognition using HIICNN Stack Ensemble Method
Authors: A Adithyan P , Aji Nandana , Jacob Serah Susan , Joy Kripa , Meckamalil Rotney Roy
Published: May 2024

Abstract: This project introduces a novel deep convolutional neural network (CNN) model aimed at enhancing traffic sign recognition for autonomous vehicle technology and road safety. Employing a stacking ensemble approach, we combine multiple CNNs with diverse improvement techniques, including preprocessing for adverse weather conditions and shooting errors, and data augmentation to handle class imbalance. Through adjustments in learning rates during model training, we mitigate overfitting. Our ensemble model achieves an exceptional 99.4 percent test accuracy on the German Traffic Sign Recognition Benchmark (GTSRB) dataset, surpassing prior studies. We utilize gradient-weighted Class Activation Mapping (Grad-CAM) for model explain- ability and an evidential deep learning approach to quantify classification uncertainty. Our framework underscores the efficacy of combining preprocessing, ensemble learning, and transfer learning for superior perfor- mance and reliability in traffic sign recognition systems, contributing significantly to autonomous driving and road safety.
Smart Safety with Password Based GSM Module Controlling Circuit Breaker
Authors: Shriwastava Dr. Rakesh G.
Published: May 2024

Abstract: This paper focus on Smart safety with password based GSM module controlling circuit breaker. In our daily life, Safety is the major concern for all activities. Accidental death of a lineman is often read and proven in current scenario. In view, safety measures to protect operators are considered to be very necessary in current working. Using passwords for security, Electrical lineman security systems are used to control circuit breakers. Serious electrical accidents occurs becoming increasingly, when repairing power lines. It is happen due to lack of communication and coordination between maintenance and substation personnel. In the proposed system, the on and off line turning operation with the lineman to ensure the safety of linemen. For that, a secure password is required to operate the breaker operation and maintenance point of view. First request is registered and password is sent to the line operator's mobile phone and GSM module by AVR microcontroller. Entered password and password received by the GSM receiver are compare. If password is match, the operation of circuit breaker will be smoothly operate. The operator gave three chances for incorrect password otherwise message will appear on the LCD display for security purposed. It also sent the message control room regarding unauthorized access to the system.
El papel de las ONG en el liderazgo educativo: estudio de caso de una ONG en Colombia
Authors: Cabra Hernández Hans Walter
Published: May 2024

La falta de herramientas que tienen los profesores para fomentar la innovación en el aula constituye uno de los grandes retos del sector educativo. Tradicionalmente se ha pensado que es el sector público el encargado de liderar los procesos de innovación y fortalecer la calidad educativa. No obstante, investigaciones en el campo del liderazgo educativo sugieren que actores como las organizaciones no gubernamentales (ONG) y los centros de pensamiento comienzan a posicionarse como líderes en el sector. El presente es un estudio de caso de la ONG Consejo de Curso, que opera en Chile y que en 2018 implementó un proyecto piloto de innovación curricular en Colombia. Con un enfoque cualitativo, se busca comprender el papel de esta ONG en la construcción de procesos de liderazgo educativo en dos centros educativos de Colombia. Para recolectar los datos realizó un grupo focal con profesores y con directores de programa de la fundación. Los hallazgos sugieren la necesidad de promover un esquema de liderazgo transformacional bottom-up que permita la participación de más actores en los procesos de innovación curricular.
Observed APO Seasonal Cycles in the Pacific: Estimation of Autumn O2 Oceanic Emissions
Authors: Tohjima Yasunori , Shirai Tomoko , Ishizawa Misa , Mukai Hitoshi , Machida T. , Sasakawa Motoki , Terao Yukio , Tsuboi Kazuhiro , Takao Shintaro , Nakaoka Shin-ichiro
Published: May 2024

In this work, we investigated the seasonal cycle of atmospheric
potential oxygen (APO), a unique tracer of air-sea gas exchanges of
molecular oxygen (O2) and carbon dioxide (CO2), expressed as APO = O2 +
1.1×CO2. APO data were obtained from flask air samples collected since
late 1990s at three Japanese ground stations and on commercial cargo
ships sailing between Japan and Australia/New Zealand, North America,
and Southeast Asia. We also analyzed the APO spatial distribution and
seasonal cycles with simulations from an atmospheric transport model,
using climatological oceanic O2 fluxes from a previous study as input.
Model simulations reproduced the observed APO seasonal cycles generally
well, but with larger amplitudes and earlier occurrence of seasonal
minima and maxima than in the observations. Moreover, the observed
seasonal cycles exhibited larger APO enhancements than the simulations
in autumn and early winter, especially in the northern North Pacific at
20°N-60°N. These enhancements remained when refining the comparison by
adjusting the simulated APO peak-to-peak amplitudes and seasonal phases
to the observations. This suggests additional O2 emissions in the North
Pacific, not well expressed in the air-sea O2 fluxes used as input for
our model simulations. The average autumn enhancement at 40°N-60°N was
approximately twice that measured at 20°N-40°N. Confirming previous
studies, our results indicate two distinct mechanisms possibly
contributing to the additional oceanic O2 emissions: outgassing from a
subsurface shallow oxygen maximum at 20°N-40°N and autumn phytoplankton
bloom at 40°N-60°N.
Climate-dependency of Impact of Increased Carbon Dioxide on African Monsoon Rainfall: Insights from model simulations
Authors: Shi Xiaoxu , Werner Martin , Pausata Francesco S.R. , Liu Jiping , D'Agostino Roberta , Hu Yongyun , Yang Hu , Wang Hang , Yang Chao-Yuan , Lohmann Gerrit
Published: May 2024

Previous studies on future scenarios identified two key effects of
increasing CO2 on the African summer monsoon (ASM): Rising CO2 leads to
an enhancement in moisture supply, favoring an increase in ASM
precipitation (the thermodynamic effect). However, it also results in a
weakening in mean atmospheric flow, thus facilitating a dryness across
the ASM region (the dynamic effect). Therefore, the ultimate change in
ASM precipitation stems from the balance of both the thermodynamic and
dynamic effects. This study further examines the impact of rising CO2 on
ASM rainfall, by taking into account various climate states. Our results
suggest that an increase in CO2 during warm interglacial periods has a
stronger influence from thermodynamic factors than from dynamic factors,
resulting in an enhancement in ASM rainfall. In contrast, if CO2
increases under cold glacial climate backgrounds, its dynamic impact
dominates a reduction of rainfall in the ASM region.
Influence of activators on spent coffee grounds as biosorbent for chromium
Authors: Yustira Ayuni , Arif Hafifuddin , Zahedi Z , Razi Fachrur
Published: May 2024

Global production of Cr (VI) can reach 44 million metric tons annually, of
which 49% is released into the environment. Developments in the industry are
to blame for this. There are numerous ways to defend against the damaging
impact that heavy metals have on the environment. The presence of Cr (VI)
metal causes environmental problems because it can endanger the physical and
ecosystem balance of aquatic fauna in river flows. Exposure to Cr (VI)
causes health problems such as liver, lung and kidney damage. Adsorption is
a straightforward, affordable, and user-friendly technique. The adsorbent
utilized is derived from biomass waste, specifically SCG, but its potential
as an adsorbent still needs to be developed. The purpose of this work was to
examine the impact of activators on activated SCG and its capacity to adsorb
Cr (VI) metal. Nitric acid and Bromide acid activators were used to activate
25 g of SCG for 1, 2, and 3 hours. Adsorbent to activator ratios are 1:4,
1:5, and 1:6. Cr (VI) solution was started at a concentration of 100 mg/L,
and the adsorption process was stirred at a rate of 300 rpm. In the
adsorption process, a ratio of 1:6 is best, along with the best activator,
which is HNO3, solution pH 4, contact time of 120 minutes, and initial
solution concentration of 20 mg/L. OH is the major functional group in all
adsorbents.
Improving indoor air quality and thermal comfort using a total heat exchanger ventilation system for an office building
Authors: Chang Linlan , Permana Indra , Wang Fujen , Prasetyo Bowo
Published: May 2024

Indoor air quality and thermal comfort affect occupant comfort and productivity. Thermal comfort supports productivity, while indoor air quality maintains occupant health. However, occupants are the main source of CO2, which is the main index for indoor pollutants in educational buildings due to many occupants gathering in one room. This study investigates the performance of applying a total heat exchanger for diluting CO2. Besides, the thermal comfort of the occupants has been evaluated extensively as the total heat exchanger also reduces the fresh air temperature. An office area with 14 graduate students seated in a meeting was investigated. Questionnaires and field measurements were conducted simultaneously. Time-varying indoor air quality (CO2 concentration) was assessed using CFD. The numerical simulation program also contained user defined function based predicted mean vote algorithms to determine occupant thermal comfort. The results indicated that without using total heat exchanger, the CO2 concentration gradually rises until it reaches a maximum of 1400 ppm inside the room. This condition occurs because there is no air change between indoor and fresh air, mainly due to the lack of fresh air supply and reliance on split air conditioning for circulation. With total heat exchanger, the concentration could lower to below 1000 ppm. In addition, it also could make room temperature slightly lower, with the overall temperature average in this study being 24.5?C without total heat exchanger and 24.1?C when total heat exchanger is operated.
Quantitative Imaging Reveals Steatosis and Fibroinflammation in Multiple Organs in People With Type 2 Diabetes: A Real-World Study
Authors: Diamond Charlie , Pansini Michele , Hamid Azlinda , Eichert Nicole , Pandya Prashant , Ali Sarah N. , Kemp Graham J. , Thanabalasingham Gaya , Thomaides Brears Helena , Cuthbertson Daniel J.
Published: May 2024

We aimed to determine the extent of multiorgan fat accumulation and fibroinflammation in individuals living with type 2 diabetes. We deeply phenotyped individuals with type 2 diabetes (134 from secondary care, 69 from primary care) with multiorgan, quantitative, multiparametric MRI and compared with 134 matched control individuals without diabetes and 92 control individuals with normal weight. We examined the impact of diabetes duration, obesity status, and glycemic control. Ninety-three of the individuals with type 2 diabetes were reevaluated at 7 months (median). Multiorgan abnormalities were more common in individuals with type 2 diabetes (94%) than in age- and BMI-matched healthy individuals or healthy individuals with normal weight. We demonstrated a high burden of combined steatosis and fibroinflammation within the liver, pancreas, and kidneys (41%, 17%, and 10%) associated with visceral adiposity (73%) and poor vascular health (82%). Obesity was most closely associated with advanced liver disease, renal and visceral steatosis, and multiorgan abnormalities, while poor glycemic control was associated with pancreatic fibroinflammation. Pharmacological therapies with proven cardiorenal protection improved liver and vascular health unlike conventional glucose-lowering treatments, while weight loss or improved glycemic control reduced multiorgan adiposity (P ≤ 0.01). Quantitative imaging in people with type 2 diabetes highlights widespread organ abnormalities and may provide useful risk and treatment stratification.

Article Highlights
Quantitative imaging reveals steatosis and fibro-inflammation in multiple organs in people with type 2 diabetes: a real-world study.
Authors: Diamond Charlie , Pansini Michele , Hamid Azlinda , Eichert Nicole , Pandya Prashant , N Ali Sarah , J Kemp Graham , Thanabalasingham Gaya , Thomaides Brears Helena , J Cuthbertson Daniel
Published: May 2024

We aimed to determine the extent of multi-organ fat accumulation and fibro-inflammation in individuals living with type 2 diabetes. We deeply phenotyped individuals with type 2 diabetes (134 from secondary care, 69 from primary care) with multi-organ, quantitative multi-parametric MRI and compared with 134 matched controls and 92 normal weight controls. We examined the impact of diabetes duration, obesity status and glycemic control. Ninety-three of the individuals with type 2 diabetes were re-evaluated at 7 months (median). Multi-organ abnormalities were more common in individuals with type 2 diabetes (94%) than in age, BMI-matched healthy or healthy normal weight people. We demonstrated a high burden of combined steatosis and fibro-inflammation, within the liver, pancreas and kidneys (41, 17 and 10%), associated with visceral adiposity (73%) and poor vascular health (82%). Obesity was most closely associated with advanced liver disease, renal and visceral steatosis, and multi-organ abnormalities whilst poor glycaemic control was associated with pancreatic fibro-inflammation. Pharmacological therapies with proven cardiorenal protection improved liver and vascular health unlike conventional glucose-lowering treatments, whilst weight loss or improved glycaemic control reduced multi-organ adiposity (p£0.01). Quantitative imaging in people with type 2 diabetes highlights widespread organ abnormalities and may provide useful risk and treatment stratification.
Implementation of perioperative FLOT compared to ECX/EOX chemotherapy regimens in resectable esophagogastric adenocarcinomas: an analysis of real-world data
Authors: Egebjerg Kristian , Andersen Tobias Sørup , Bæksgaard Lene , Garbyal Rajendra , Siemsen Mette , Achiam Michael , Mau-Sørensen Paul Morten
Published: May 2024

Background and purpose: Perioperative 5-FU, leucovorin, oxaliplatin, and docetaxel (FLOT) is recommended in resectable esophagogastric adenocarcinoma based on randomised trials. However, the effectiveness of FLOT in routine clinical practice remains unknown as randomised trials are subject to selection bias limiting their generalisability. The aim of this study was to evaluate the implementation of FLOT in real-world patients.
Methods: Retrospectively collected data were analysed in consecutive patients treated before or after the implementation of FLOT. The primary endpoint was complete pathological response (pCR) and secondary endpoints were margin-free resection (R0), overall survival (OS), relapse-free survival (RFS) tolerability of chemotherapy and surgical complications.
Results: Mean follow-up time for patients treated with FLOT (n = 205) was 37.7 versus 47.0 months for epirubicin, cis- or oxaliplatin, and capecitabine (ECX/EOX, n = 186). Surgical resection was performed in 88.0% versus 92.0%; pCR were observed in 3.8% versus 2.4%; and R0 resections were achieved in 78.0% versus 86.0% (p = 0.03) in the ECX/EOX and FLOT cohorts, respectively. Survival analysis indicated no significant difference in RFS (p = 0.17) or OS (p = 0.37) between the cohorts with a trend towards increased OS in performance status 0 (hazard ratio [HR] = 0.73, 95% confidence interval [CI]: 0.50–1.04). More patients treated with ECX/EOX completed chemotherapy (39% vs. 28%, p = 0.02). Febrile neutropenia was more common in the FLOT cohort (3.8% vs. 11%, p = 0.0086). 90-days mortality (1.2% vs. 0%) and frequency of anastomotic leakage (8% vs. 6%) were equal and low.
Interpretation: Patients receiving FLOT did not demonstrate improved pCR, RFS or OS. However, R0 rate was improved and patients in good PS trended towards improved OS.
End-stage renal disease after renal cancer surgery: risk factors and overall survival
Authors: Åkerlund John , Ljungberg Börje , Lundstam Sven , Peeker Ralph , Holmberg Erik , Månsson Marianne , Grenabo Bergdahl Anna
Published: May 2024

Objective: Several risk factors for end-stage renal disease (ESRD), in patients undergoing surgical treatment for renal cell carcinoma (RCC), have been suggested by others. This study aimed to investigate such risk factors and disclose the effect of developing ESRD, postoperatively, on overall survival. The risk of developing ESRD after RCC diagnosis was also evaluated.
Material and methods: The data of 16,220 patients with RCC and 162,199 controls were extracted from the Renal Cell Cancer Database Sweden, with linkages across multiple national registers between 2005 and 2020. Cox proportional hazards regression, Kaplan–Meier curves and cumulative incidence were used for statistical analysis.
Results: The 5-year cumulative incidence of ESRD following RCC diagnosis was 2.4% (95% confidence interval [CI] 2.1–2.6) and 0.4% (95% CI 0.3–0.4) for the patients with RCC and controls, respectively. Age, chronic kidney disease, higher T-stage and radical nephrectomy (RN) were significant risk factors for ESRD within 1-year of surgery. A total of 104 and 12,152 patients with and without ESRD, respectively, survived 1-year postoperatively. The 5-year overall survival rates of patients with ESRD and those with RCC only were 50% (95% CI 0.40–0.60) and 80% (95% CI 0.80–0.81), respectively.
Conclusions: Patients who developed ESRD following renal cancer surgery had significantly poorer survival outcomes. Advanced age, comorbidities, higher-stage tumours and RN were identified as risk factors for developing ESRD. Surgical decisions are crucial. Efforts to spare renal function, including nephron-sparing surgery and active surveillance in appropriate cases, are highly relevant to reduce the development of severe kidney dysfunction.
Linguagem audiovisual, multiletramentos e inovação
Authors: Freire Maximina M. , Sá Cristiane Freire de
Published: May 2024

Este artigo discute a importância da linguagem audiovisual na produção de vídeos educacionais, tendo os multiletramentos como possibilidade de inovação pedagógica. Wohlgemuth (2005) e Priuli (2017) problematizam a produção de vídeos educacionais, considerando a perspectiva de uma produção essencialmente pedagógica, rompendo a reprodutibilidade estabelecida pela indústria midiática. Ribeiro (2016) e Rojo e Moura (2019) aprofundam a questão, ressaltando a inclusão de educadores nos processos de produção. Nessa direção, este artigo discute a importância de professores e alunos ampliarem sua proficiência na linguagem audiovisual sob a perspectiva dos multiletramentos, colocando as práticas sociais como centrais na promoção de processos pedagógicos inovativos, colaborativos e de coautoria. Esses processos são ilustrados por algumas estratégias baseadas em princípios colaborativos como inspiração para a vivência de práticas inovadoras na produção audiovisual educativa.
Experimental and numerical investigations on bending behavior of fixed open-web steel beams
Authors: Zheng Z. , Xia X. , Ji W. , Ye J. , Wu J. , Lin H.
Published: May 2024

The effects of opening parameters on the bending behavior of fixed open-web steel beams under static loading were experimentally investigated using six specimens of different opening length-to-height ratios, area ratios, and distributions. The experimentally obtained failure modes, bearing capacities, and load-displacement curves of the specimens were compared with those extracted from numerical simulations performed via Abaqus finite element analysis software. The results revealed the following: (i) The typical failure mode of the fixed open-web steel beams was plastic failure at the opening corners in the shear-bending sections, with compressive corners experiencing flexion and tensile corners experiencing tearing. (ii) For a given opening area ratio and opening height-to-beam height ratios, decreasing the opening length and increasing the number of openings significantly increased the bearing capacity of the open-web beam (by more than one-fold) when the openings were appropriately configured, compared with beams with a small number of large openings. (iii) Increasing the opening height and length had similar effects on the bending behavior of the open-web beam.
Multiple Myeloma Revealed by a Plasmacytoma of the Sphenoid Sinus in a Young Subject: Case Report
Authors: Bennane Wafaa , Bencharef Hanaa , Oukkache Bouchra
Published: May 2024

Extramedullary plasmacytomas are a rare entity. They represent less than 1% of malignant head and neck tumors. We report the case of a 42-year-old patient complaining of headache, ptosis of the right eye and hypoesthesia of the face evolving for a few weeks. MRI showed a mass in the sphenoid sinus with local extension. The myelogram objectified the presence of 60% dystrophic plasma cells, which confirms the diagnosis of multiple myeloma. The patient received chemotherapy with a good course. Here, we report a rare case of sphenoidal sinus plasmacytoma that evolved into multiple myeloma.
Rynek kredytów hipotecznych w Polsce
Authors: Dąbrowska Aleksandra , Kurek Olga , Kwiatkowska Klaudia , Piechota Karina , Potasznik Alicja , Sosnowska Kamila
Published: May 2024

Decyzje o udzieleniu kredytu uzależnione są od wielu czynników. Wynikają głównie z procedur oceny zdolności kredytowej opracowanych przez bank oraz określania stopnia ryzyka związanego z kredytem, które leży po stronie ubiegającego się o niniejszy sposób dofinansowania (historia kredytowa itp.). Kredyt hipoteczny, któremu poświęcona została tematyka artykułu może być przeznaczony na budowę nieruchomości czy też zakup gruntów. Celem opracowania jest przedstawienie charakterystyki rynku kredytów hipotecznych w Polsce pod kątem definicji, klasyfikacji, procesów oceny zdolności kredytowej oraz związanych z tym kosztów oraz ich struktury.
Exploring the Relationship Between Diversification, Risk Bank, Size Bank, and Liquidity; Evidence From Conventional Banking In Indonesia
Authors: Indraswari Citra Rahayu , Sari Kartika , Anggraeni Puspitasari Wahyu
Published: May 2024

Banking plays an important role in the economy both micro and macro. In addition, it is crucial for a country to have a strong and robust banking system. To realize a strong and robust banking banks need to maintain their efficiency. Therefore, it is necessary to identify the factors that affect efficiency, including asset diversification, risk, bank size and bank liquidity. The novelty of this research is that there is an asset diversification variable. Asset diversification can protect investors from recurring investment cycles and can save from asset failure. The sample of this research are conventional banks with a total of 10 banks that have the largest share of assets in Indonesia. In this study to identify the effect of asset diversification, bank risk, bank size, and bank liquidity on bank efficiency used multiple linear regression analysis methods were used. This study concludes that asset diversification actually reduces bank efficiency. The increased bank risk, the better efficiency. Then, the size of the bank and liquidity have no effect on efficiency. Therefore, banks need to review the diversification strategy, ensure that the risks associated with each asset and portfolio as a whole are well-identified and look for opportunities to automate repetitive processes and reduce overall operational costs. Through this research, we suggest, (i) Banks need to review the diversification strategy that has been implemented. There may be some areas or types of assets that do not fit the risk profile and objectives of the bank, (ii) Banks need to ensure that the risks associated with each asset and portfolio as a whole are well-identified, measured and managed, (iii) Banks need to look for opportunities to automate repetitive processes and reduce overall operational costs.