bluuebunny/crossref_metadata_2025 huggingface dataset:
Heteroleptic complexesviasolubility control: examples of Cu(ii), Co(ii), Ni(ii) and Mn(ii) complexes based on the derivatives of terpyridine and hydroxyquinoline
Authors: Baskin Maria , Fridman Natalia , Kosa Monica , Maayan Galia
Published: October 2017

We describe the preparation of synthetically challenging heteroleptic complexes by considering the solubility properties of their corresponding favored homoleptic complexes.
Catalytic applications of small bite-angle diphosphorus ligands with single-atom linkers
Authors: Mansell S. M.
Published: October 2017

Diphosphorus ligands connected by a single atom (R2PEPR2; E = CR2, CCR2and NR) give chelating ligands with very small bite-angles as well as enable access to other properties such as bridging modes and hemilability. ThisPerspectivereviews the properties of diphosphorus ligands featuring a single-atom linker and their applications in catalysis, including transformations of alkenes and transfer hydrogenation and hydrogen-borrowing reactions.
Catalyst free boron carbon bond cleavage and facile formation of five-membered PNBCC heterocycles
Authors: Dasgupta Rajarshi , Panda Atanu , Pal Shiv , Veetil Muhasina Puthan , De Susmita , Parameswaran Pattiyil , Khan Shabana
Published: October 2017

The [3 + 2] cycloaddition reaction of N(2,6-iPr2C6H3)(PPh2)(BCy2) (1) with activated alkynes led to the boron, phosphorus containing five-membered heterocycles (2–4) with facile cleavage of B–C bond and concomitant formation of a P–C bond with an ylidic character.
Effects of cyanidin 3-0-glucoside on cardiac structure and function in an animal model of myocardial infarction
Authors: Raj Pema , McCallum Jason L. , Kirby Christopher , Grewal Gurman , Yu Liping , Wigle Jeffrey T. , Netticadan Thomas
Published: October 2017

Cyanidin 3-0-glucoside (CG) is a polyphenol with potential health benefits.
Exosomal delivery of berry anthocyanidins for the management of ovarian cancer
Authors: Aqil Farrukh , Jeyabalan Jeyaprakash , Agrawal Ashish K. , Kyakulaga Al-Hassan , Munagala Radha , Parker Lynn , Gupta Ramesh C.
Published: October 2017

The exosomal formulation of berry Anthos elicits potent therapeutic activity against both the drug-sensitive and drug-resistant human ovarian cancer cells in vitro and in vivo.
The antibacterial and antibiofilm efficacies of a liposomal peptide originating from rice bran protein against Listeria monocytogenes
Authors: Pu Chuanfen , Tang Wenting
Published: October 2017

A liposomal peptide (Lys-Val-Asp-His-Phe-Pro-Leu) originating from rice bran protein exhibits antibacterial and antibiofilm efficacies against Listeria monocytogenes.
Isolation and identification of calcium-chelating peptides from Pacific cod skin gelatin and their binding properties with calcium
Authors: Wu Wenfei , Li Bafang , Hou Hu , Zhang Hongwei , Zhao Xue
Published: October 2017

Two novel calcium-chelating peptides have been identified from Pacific cod skin gelatin, and the binding mode of the two peptides with calcium has been elucidated.
Insights of biomass recalcitrance in naturalPopulus trichocarpavariants for biomass conversion
Authors: Yoo Chang Geun , Yang Yongil , Pu Yunqiao , Meng Xianzhi , Muchero Wellington , Yee Kelsey L. , Thompson Olivia A. , Rodriguez Miguel , Bali Garima , Engle Nancy L. , Lindquist Erika , Singan Vasanth , Schmutz Jeremy , DiFazio Stephen P. , Tschaplinski Timothy J. , Tuskan Gerald A. , Chen Jin-Gui , Davison Brian , Ragauskas Arthur J.
Published: October 2017

The recalcitrance of naturalPopulusvariants was elucidated.
Wavelet-based interference correction for laser-induced breakdown spectroscopy
Authors: Guo Y. M. , Deng L. M. , Yang X. Y. , Li J. M. , Li K. H. , Zhu Z. H. , Guo L. B. , Li X. Y. , Lu Y. F. , Zeng X. Y.
Published: October 2017

A wavelet-based interference correction approach was proposed to improve the accuracy of LIBS quantitative analysis.
Cu(ii), Ga(iii) and In(iii) complexes of 2-acetylpyridine N(4)-phenylthiosemicarbazone: synthesis, spectral characterization and biological activities
Authors: Wang Yu-Ting , Fang Yan , Zhao Meng , Li Ming-Xue , Ji Yu-Mei , Han Qiu-Xia
Published: October 2017

The complexes possess effective antibacterial activity and considerable cytotoxicity against HepG2 cells. In addition, the indium(iii) complex exhibits excellent photoluminescence properties.
Optically reconfigurable chiral microspheres of self-organized helical superstructures with handedness inversion
Authors: Wang Ling , Chen Dong , Gutierrez-Cuevas Karla G. , Krishna Bisoyi Hari , Fan Jing , Zola Rafael S. , Li Guoqiang , Urbas Augustine M. , Bunning Timothy J. , Weitz David A. , Li Quan
Published: October 2017

Light-driven monodisperse chiral microsphere with dynamic chirality was fabricatedviaa capillary-based microfluidic technique.
Zinc’ing it out: zinc homeostasis mechanisms and their impact on the pathogenesis of human pathogen group A streptococcus
Authors: Makthal Nishanth , Kumaraswami Muthiah
Published: October 2017

The ability ofStreptococcus pyogenesto resist host-mediated zinc starvation or poisoning is critical for bacterial pathogenesis.
Synergistic effect of cross-linked carbon nanosheet frameworks and Sb on the enhancement of sodium storage performances
Authors: Hou Hongshuai , Zou Guoqiang , Ge Peng , Zhao Ganggang , Wei Weifeng , Ji Xiaobo , Huang Lanping
Published: October 2017

Cross-linked carbon nanosheets (CCNFs) are employed to anchor Sb nanoparticles to improve the sodium storage performances, and the synergistic effect of cross-linked carbon nanosheet frameworks and Sb is investigated.
Iso-solvation effects in mixtures of ionic liquids on the kinetics of a model SNAr reaction
Authors: Alarcón-Espósito J. , Contreras R. , Campodónico P. R.
Published: October 2017

The SNAr reaction between 1-chloro-2,4-dinitrobenzene and morpholine was used as a model system to study solvation effects in a series of mixtures involving imidazolium based ionic liquids.
Enhanced catalytic activity and stability of copper and nitrogen doped titania nanorod supported Pt electrocatalyst for oxygen reduction reaction in polymer electrolyte fuel cells
Authors: Dhanasekaran P. , Selvaganesh S. Vinod , Bhat Santoshkumar D.
Published: October 2017

Copper and nitrogen doped TiO2 nanorod supported platinum with enhanced oxygen reduction and long-term durability in PEFCs.
Efficient liposome fusion mediated by lipid–nucleic acid conjugates
Authors: Ries O. , Löffler P. M. G. , Rabe A. , Malavan J. J. , Vogel Stefan
Published: October 2017

Highly efficient fusion and content mixing of liposomes encoded by lipidated oligonucleotides (LiNAs). “Hot fusion of biomembranes” – a low leakage process at elevated temperature.
A ROS-responsive polymeric micelle with a π-conjugated thioketal moiety for enhanced drug loading and efficient drug delivery
Authors: Sun Changzhen , Liang Yan , Hao Na , Xu Long , Cheng Furong , Su Ting , Cao Jun , Gao Wenxia , Pu Yuji , He Bin
Published: October 2017

As the implications of reactive oxygen species (ROS) are elucidated in many diseases, ROS-responsive nanoparticles are attracting great interest from researchers.
Straightforward synthesis of Man9, the relevant epitope of the high-mannose oligosaccharide
Authors: Ramos-Soriano Javier , de la Fuente M. Carmen , de la Cruz Noelia , Figueiredo Rute C. , Rojo Javier , Reina José J.
Published: October 2017

The high-mannose oligosaccharide (or its corresponding Man9 epitope) is the most abundant structure present in pathogen envelope glycoproteins. In this work, a very efficient synthetic alternative was described to access this relevant Man9 epitope in a very straightforward manner.
Acrylamides with hydrolytically labile carbonate ester side chains as versatile building blocks for well-defined block copolymer micelles via RAFT polymerization
Authors: Kasmi Sabah , Louage Benoit , Nuhn Lutz , Verstraete Glenn , Van Herck Simon , van Steenbergen Mies J. , Vervaet Chris , Hennink Wim E. , De Geest Bruno G.
Published: October 2017

Hydrophobic modification of N-(2-hydroxyethyl)acrylamide yields a class of building blocks that is attractive for biomaterial synthesis.
Highly mono-selective ortho-methylthiolation of benzamides via cobalt-catalyzed sp2 C–H activation
Authors: Hu Liang , Chen Xiang , Yu Lin , Yu Yongqi , Tan Ze , Zhu Gangguo , Gui Qingwen
Published: October 2017

A highly mono-selective ortho-methylthiolation of benzamides was achieved via Co-catalyzed coupling of benzamides with DMSO.
Regioselective C5 alkenylation of 2-acylpyrroles via Pd(ii)-catalyzed C–H bond activation
Authors: Duan Jian-Hua , Mi Rui-Jie , Sun Jing , Zhou Ming-Dong
Published: October 2017

A Pd(ii)-catalyzed regioselective C5 alkenylation of 2-acylpyrroles to synthesize various C5-alkenylated 2-acylpyrroles using a readily removable N-protecting group is developed.
Visible-light-induced sulfonylation/cyclization of vinyl azides: one-pot construction of 6-(sulfonylmethyl)phenanthridines
Authors: Mao Liu-Liang , Zheng Da-Gui , Zhu Xian-Hong , Zhou An-Xi , Yang Shang-Dong
Published: October 2017

A facile and efficient protocol has been developed for sulfonylation/cyclization of vinyl azides under photoredox conditions.
l-Phenylalanine potassium catalyzed asymmetric formal [3 + 3] annulation of 2-enoyl-pyridineN-oxides with acetone
Authors: Xu Youguo , Zhang Sheng , Li Lijun , Wang Yukang , Zha Zhenggen , Wang Zhiyong
Published: October 2017

A highly enantioselective formal [3 + 3] annulation of 2-enoyl-pyridineN-oxides with acetone was developed.
Visible-light promoted arene C–H/C–X lactonizationviacarboxylic radical aromatic substitution
Authors: Yang Qi , Jia Zongbin , Li Longji , Zhang Long , Luo Sanzhong
Published: October 2017

Photocatalytic carboxylic radical aromatic substitution enables the synthesis of diversely substituted coumarins by inert C–X bond cleavage under mild conditions.
Comment on “Microwave synthesis of graphene/magnetite composite electrode material for symmetric supercapacitor with superior rate performance” by K. Karthikeyan, D. Kalpana, S. Amaresh and Y. S. Lee, RSC Adv., 2012, 2, 12322
Authors: M. Rajaperumal
Published: October 2017

Recently, the number of research publications has increased drastically in the field of supercapacitors.
Mussel-inspired hydrogel tissue adhesives for wound closure
Authors: Rahimnejad Maedeh , Zhong Wen
Published: October 2017

Tissue adhesives have been introduced as a promising alternative for the traditional wound closure method of suturing.
Boron- and nitrogen-doped photoluminescent polymer carbon nanoparticles as nanosensors for imaging detection of Cu2+ and biothiols in living cells
Authors: Gao Buhong , Zhao Fengyi , Miao Yingchun , Min Huihua , Xu Li , Huang Chaobo
Published: October 2017

Boron and nitrogen co-doped ellipsoidal polymer carbon nanoparticles-based nanoprobe for fluorescence detection and imaging of biothiols in biological samples.
Mechanically robust, thermally stable, highly transparent superhydrophobic coating with low-temperature sol–gel process
Authors: Zhang Yanping , Dong Binghai , Wang Shimin , Zhao Li , Wan Li , Wang Erjing
Published: October 2017

The wetting behavior of transparent superhydrophobic surfaces has attracted much attention in our daily life as well as in engineering applications.
Co–N–C supported on SiO2: a facile, efficient catalyst for aerobic oxidation of amines to imines
Authors: Zhang Chenghui , Zhao Pengshan , Zhang Zongliang , Zhang Jingwei , Yang Ping , Gao Peng , Gao Jun , Liu Di
Published: October 2017

The aerobic oxidation of amines to imines was catalyzed by Co–C–N/SiO2 which was obtained by the pyrolysis of silicone gel containing metal ion and triethanolamine.
Large-scale preparation of flexible and reusable surface-enhanced Raman scattering platform based on electrospinning AgNPs/PCL nanofiber membrane
Authors: Shi Jihua , You Tingting , Gao Yukun , Liang Xiu , Li Chenling , Yin Penggang
Published: October 2017

A flexible and reusable SERS substrates were prepared by electrospinning Ag nanoparticles in reversed micelle into poly(ε-caprolactone) nanofibers.
An ionic liquid–organic solvent biphasic system for efficient production of 5-hydroxymethylfurfural from carbohydrates at high concentrations
Authors: Hou Qidong , Li Weizun , Zhen Meinan , Liu Le , Chen Yu , Yang Qian , Huang Fang , Zhang Shiqiu , Ju Meiting
Published: October 2017

A biphasic system consisting of EMIMBr/SnCl4 and organic solvent was developed to produce HMF from carbohydrates at high concentrations.
Precision polymers containing main-chain-amino acids: ADMET polymerization and crystallization
Authors: Freudenberg Jan , Poppe Silvio , Binder Wolfgang H.
Published: October 2017

New PE-type precision oligomers displaying different amino acids (chiral/achiral, polar/non-polar) placed at every 19th carbon atom are presented.
Influence of the [4Fe–4S] cluster coordinating cysteines on active site maturation and catalytic properties of C. reinhardtii [FeFe]-hydrogenase
Authors: Kertess Leonie , Adamska-Venkatesh Agnieszka , Rodríguez-Maciá Patricia , Rüdiger Olaf , Lubitz Wolfgang , Happe Thomas
Published: October 2017

Alteration of the [4Fe–4S] cluster coordinating cysteines reveals their individual importance for [4Fe–4S] cluster binding, [2Fe] insertion and catalytic turnover.
The α-tertiary amine motif drives remarkable selectivity for Pd-catalyzed carbonylation of β-methylene C–H bonds
Authors: Hogg Kirsten F. , Trowbridge Aaron , Alvarez-Pérez Andrea , Gaunt Matthew J.
Published: October 2017

The selective C–H carbonylation of methylene bonds, in the presence of traditionally more reactive methyl C–H and C(sp2)–H bonds, in α-tertiary amines is reported.
Abnormal room temperature phosphorescence of purely organic boron-containing compounds: the relationship between the emissive behaviorand the molecular packing, and the potential related applications
Authors: Chai Zhaofei , Wang Can , Wang Jinfeng , Liu Fan , Xie Yujun , Zhang Yong-Zheng , Li Jian-Rong , Li Qianqian , Li Zhen
Published: October 2017

Long-lived RT phosphorescence was achieved with a series of organic boron-containing compounds due to the rigid conformation and effective π–π stacking in the solid states.
Ruthenium(ii)-catalyzed olefinationviacarbonyl reductive cross-coupling
Authors: Wei Wei , Dai Xi-Jie , Wang Haining , Li Chenchen , Yang Xiaobo , Li Chao-Jun
Published: October 2017

A catalytic olefination methodviacarbonyl reductive cross-coupling was achieved by ruthenium(ii) catalysis.
Liquid-based stationary phase for deterministic lateral displacement separation in microfluidics
Authors: Du Siqi , Shojaei-Zadeh Shahab , Drazer German
Published: October 2017

An array of liquid-bridges replaces the usual solid posts in this separation system, demonstrating the possibility of using an immiscible liquid to create the stationary phase in separation systems.
Three-dimensional electric micro-grid networks for high-energy-density lithium-ion battery cathodes
Authors: Kim Dae-wook , Zettsu Nobuyuki , Teshima Katsuya
Published: October 2017

High-energy-density LiNi0.5Co0.2Mn0.3O2 (NCM523) cathodes are prepared by the reduction of carbon additive loading based on the self-organization of water-soluble multiwalled carbon nanotubes (MW-CNTs) into MW-CNT/NCM523 supramolecular assemblies.
Development of a new alluaudite-based cathode material with high power and long cyclability for application in Na ion batteries in real-life
Authors: Kim Jongsoon , Kim Hyungsub , Lee Seongsu , Myung Seung-Taek
Published: October 2017

Na2Fe1.96V0.96(PO4)3 (NFVP) that exhibits outstanding cycle life and great power capability with a high redox potential for the first time.
Novel imidazolium-based poly(ionic liquid)s with different counterions for self-healing
Authors: Cui Jing , Nie Feng-Min , Yang Ji-Xing , Pan Li , Ma Zhe , Li Yue-Sheng
Published: October 2017

Novel polymerized ionic liquids with different counterions were constructed, where ionic aggregations serve as physical cross-links providing excellent self-healing performance.
Optimisation of oxide-ion conductivity in acceptor-doped Na0.5Bi0.5TiO3 perovskite: approaching the limit?
Authors: Yang F. , Li M. , Li L. , Wu P. , Pradal-Velázque E. , Sinclair D. C.
Published: October 2017

σb of NBT is optimised by acceptor-doping, which is restrained by oxygen-vacancy diffusivity limit in perovskites.
Potassium ferrous ferricyanide nanoparticles as a high capacity and ultralong life cathode material for nonaqueous potassium-ion batteries
Authors: Chong Shaokun , Chen Yuanzhen , Zheng Yang , Tan Qiang , Shu Chengyong , Liu Yongning , Guo Zaiping
Published: October 2017

KFeII[FeIII(CN)6] with a symmetric cubic structure exhibits exceptional electrochemical performance based on a solid solution mechanism, and its high structural stability and electrochemical reversibility.
Photoactive antimicrobial nanomaterials
Authors: Feng Yonghai , Liu Lei , Zhang Jie , Aslan Hüsnü , Dong Mingdong
Published: October 2017

Nanomaterials for killing pathogenic bacteria under light irradiation.
NIR light-activated dual-modality cancer therapy mediated by photochemical internalization of porous nanocarriers with tethered lipid bilayers
Authors: Liu Junjie , Şen Karaman Didem , Zhang Jixi , Rosenholm Jessica M. , Guo Xingming , Cai Kaiyong
Published: October 2017

Tethered lipid bilayers on porous nanocarriers facilitate photochemical internalization and efficient cancer therapy via NIR irradiation.
Cross-linked polymers with fluorinated bridges for efficient gene delivery
Authors: Xiao Ya-Ping , Zhang Ji , Liu Yan-Hong , Huang Zheng , Wang Bing , Zhang Yi-Mei , Yu Xiao-Qi
Published: October 2017

A new strategy for the construction of fluorinated cationic polymers for gene delivery was introduced.
Blood brain barrier permeable gold nanocluster for targeted brain imaging and therapy: an in vitro and in vivo study
Authors: Nair L. V. , Nair R. V. , Shenoy S. J. , Thekkuveettil A. , Jayasree R. S.
Published: October 2017

l-Dopa conjugated fluorescent gold cluster to cross undisturbed blood brain barrier for early stage imaging and drug delivery.
Pyridal[2,1,3]thiadiazole as strong electron-withdrawing and less sterically-hindered acceptor for highly efficient donor–acceptor type NIR materials
Authors: Jiang Jianxia , Li Xianglong , Hanif Muddasir , Zhou Jiadong , Hu Dehua , Su Shijian , Xie Zengqi , Gao Yu , Yang Bing , Ma Yuguang
Published: October 2017

High efficiency NIR emissive materials is rational designed based on PT with strongly mixed S1 of LE and CT states.
The MUSE Hubble Ultra Deep Field Survey
Authors: Bacon Roland , Conseil Simon , Mary David , Brinchmann Jarle , Shepherd Martin , Akhlaghi Mohammad , Weilbacher Peter M. , Piqueras Laure , Wisotzki Lutz , Lagattuta David , Epinat Benoit , Guerou Adrien , Inami Hanae , Cantalupo Sebastiano , Courbot Jean Baptiste , Contini Thierry , Richard Johan , Maseda Michael , Bouwens Rychard , Bouché Nicolas , Kollatschny Wolfram , Schaye Joop , Marino Raffaella Anna , Pello Roser , Herenz Christian , Guiderdoni Bruno , Carollo Marcella
Published: October 2017

We present the MUSE Hubble Ultra Deep Survey, a mosaic of nine MUSE fields covering 90% of the entire HUDF region with a 10-h deep exposure time, plus a deeper 31-h exposure in a single 1.15 arcmin2 field. The improved observing strategy and advanced data reduction results in datacubes with sub-arcsecond spatial resolution (0.̋65 at 7000 Å) and accurate astrometry (0.̋07 rms). We compare the broadband photometric properties of the datacubes to HST photometry, finding a good agreement in zeropoint up to mAB = 28 but with an increasing scatter for faint objects. We have investigated the noise properties and developed an empirical way to account for the impact of the correlation introduced by the 3D drizzle interpolation. The achieved 3σ emission line detection limit for a point source is 1.5 and 3.1 × 10-19 erg s-1 cm-2 for the single ultra-deep datacube and the mosaic, respectively. We extracted 6288 sources using an optimal extraction scheme that takes the published HST source locations as prior. In parallel, we performed a blind search of emission line galaxies using an original method based on advanced test statistics and filter matching. The blind search results in 1251 emission line galaxy candidates in the mosaic and 306 in the ultradeep datacube, including 72 sources without HST counterparts (mAB > 31). In addition 88 sources missed in the HST catalog but with clear HST counterparts were identified. This data set is the deepest spectroscopic survey ever performed. In just over 100 h of integration time, it provides nearly an order of magnitude more spectroscopic redshifts compared to the data that has been accumulated on the UDF over the past decade. The depth and high quality of these datacubes enables new and detailed studies of the physical properties of the galaxy population and their environments over a large redshift range.
Using radio astronomical receivers for molecular spectroscopic characterization in astrochemical laboratory simulations: A proof of concept
Authors: Tanarro I. , Alemán B. , de Vicente P. , Gallego J. D. , Pardo J. R. , Santoro G. , Lauwaet K. , Tercero F. , Díaz-Pulido A. , Moreno E. , Agúndez M. , Goicoechea J. R. , Sobrado J. M. , López J. A. , Martínez L. , Doménech J. L. , Herrero V. J. , Hernández J. M. , Peláez R. J. , López-Pérez J. A. , Gómez-González J. , Alonso J. L. , Jiménez E. , Teyssier D. , Makasheva K. , Castellanos M. , Joblin C. , Martín-Gago J. A. , Cernicharo J.
Published: October 2017

We present a proof of concept on the coupling of radio astronomical receivers and spectrometers with chemical reactors and the performances of the resulting setup for spectroscopy and chemical simulations in laboratory astrophysics. Several experiments including cold plasma generation and UV photochemistry were performed in a 40 cm long gas cell placed in the beam path of the Aries 40 m radio telescope receivers operating in the 41–49 GHz frequency range interfaced with fast Fourier transform spectrometers providing 2 GHz bandwidth and 38 kHz resolution. The impedance matching of the cell windows has been studied using different materials. The choice of the material and its thickness was critical to obtain a sensitivity identical to that of standard radio astronomical observations. Spectroscopic signals arising from very low partial pressures of CH3OH, CH3CH2OH, HCOOH, OCS, CS, SO2 (<10-3 mbar) were detected in a few seconds. Fast data acquisition was achieved allowing for kinetic measurements in fragmentation experiments using electron impact or UV irradiation. Time evolution of chemical reactions involving OCS, O2 and CS2 was also observed demonstrating that reactive species, such as CS, can be maintained with high abundance in the gas phase during these experiments.
A study of dust properties in the inner sub-au region of the Herbig Ae star HD 169142 with VLTI/PIONIER
Authors: Chen L. , Kóspál Á. , Ábrahám P. , Kreplin A. , Matter A. , Weigelt G.
Published: October 2017

Context. An essential step to understanding protoplanetary evolution is the study of disks that contain gaps or inner holes. The pre-transitional disk around the Herbig star HD 169142 exhibits multi-gap disk structure, differentiated gas and dust distribution, planet candidates, and near-infrared fading in the past decades, which make it a valuable target for a case study of disk evolution.

Aims. Using near-infrared interferometric observations with VLTI/PIONIER, we aim to study the dust properties in the inner sub-au region of the disk in the years 2011−2013, when the object is already in its near-infrared faint state.

Methods. We first performed simple geometric modeling to characterize the size and shape of the NIR-emitting region. We then performed Monte-Carlo radiative transfer simulations on grids of models and compared the model predictions with the interferometric and photometric observations.

Results. We find that the observations are consistent with optically thin gray dust lying at Rin ~ 0.07 au, passively heated to T ~ 1500 K. Models with sub-micron optically thin dust are excluded because such dust will be heated to much higher temperatures at similar distance. The observations can also be reproduced with a model consisting of optically thick dust at Rin ~ 0.06 au, but this model is plausible only if refractory dust species enduring ~ 2400 K exist in the inner disk.
Globally Lipschitz minimizers for variational problems with linear growth
Authors: Beck Lisa , Bulíček Miroslav , Maringová Erika
Published: October 2017

We study the minimization of convex, variational integrals of linear growth among all functions in the Sobolev spaceW1,1with prescribed boundary values (or its equivalent formulation as a boundary value problem for a degenerately elliptic Euler–Lagrange equation). Due to insufficient compactness properties of these Dirichlet classes, the existence of solutions does not follow in a standard way by the direct method in the calculus of variations and in fact might fail, as it is well-known already for the non-parametric minimal surface problem. Assuming radial structure, we establish a necessary and sufficient condition on the integrand such that the Dirichlet problem is in general solvable, in the sense that a Lipschitz solution exists for any regular domain and all prescribed regular boundary values,viathe construction of appropriate barrier functions in the tradition of Serrin’s paper [J. Serrin,Philos. Trans. R. Soc. Lond., Ser. A264(1969) 413–496].
Small and large scale behavior of moments of Poisson cluster processes
Authors: Antunes Nelson , Pipiras Vladas , Abry Patrice , Veitch Darryl
Published: October 2017

Poisson cluster processes are special point processes that find use in modeling Internet traffic, neural spike trains, computer failure times and other real-life phenomena. The focus of this work is on the various moments and cumulants of Poisson cluster processes, and specifically on their behavior at small and large scales. Under suitable assumptions motivated by the multiscale behavior of Internet traffic, it is shown that all these various quantities satisfy scale free (scaling) relations at both small and large scales. Only some of these relations turn out to carry information about salient model parameters of interest, and consequently can be used in the inference of the scaling behavior of Poisson cluster processes. At large scales, the derived results complement those available in the literature on the distributional convergence of normalized Poisson cluster processes, and also bring forward a more practical interpretation of the so-called slow and fast growth regimes. Finally, the results are applied to a real data trace from Internet traffic.
Update on Pediatric Hip Imaging
Authors: Vanhoenacker Filip , Jaremko Jacob , Jans Lennart , Herregods Nele
Published: October 2017

Hip disorders are common in children. Prompt diagnosis and treatment are important because of the potential complications. Symptoms are frequently nonspecific, and clinical examination can be difficult and unreliable, especially in smaller children. Therefore, imaging can be valuable. Radiography and ultrasound remain the initial imaging modalities of choice. Increasingly, magnetic resonance imaging is obtained for assessing the pediatric hip, although the long imaging time and need for sedation may limit its use in daily practice. Because of the exposure to ionizing radiation, the use of computed tomography and bone scintigraphy in children is limited to selected cases. Pediatric hip pathology varies depending on patient age. This article provides an overview of common hip pathologies in children including congenital and developmental pathologies, trauma, infectious processes, inflammatory disease, and neoplasm. The age of the child, history, and clinical examination are essential to narrow down the differential diagnosis and subsequent selection of the appropriate imaging modality.
Advanced MR Imaging after Total Hip Arthroplasty: The Clinical Impact
Authors: Khodarahmi Iman , Fritz Jan
Published: October 2017

Recent metal artifact reduction techniques in magnetic resonance imaging (MRI) have sparked a new aera in visualization of the peri-implant region and assessment of failing orthopaedic hardware. Modes of failure after total hip arthroplasty can be classified into four broad categories: osseous abnormalities, implant instability and dislocation, implant-associated synovitis, and soft tissue abnormalities. Although MRI is complementary to plain radiography and computed tomography to diagnose the first two categories, it is paramount to investigate the complications related to the synovium and soft tissues. We review the most common modes of failure of hip implants and the MRI characteristics of various causes of pain and dysfunction after hip arthroplasty including osseous stress reaction and fracture, implant loosening, implant instability, polyethylene wear–induced synovitis, adverse reaction to metal debris, infection, hematoma, recurrent hemarthrosis, heterotopic ossification, muscle, tendon, and nerve abnormalities, and periprosthetic neoplasms.
Application of Indocyanine Green in Flap Surgery: A Systematic Review
Authors: Li Ke , Zhang Zheng , Nicoli Fabio , D'Ambrosia Christopher , Xi Wenjing , Lazzeri Davide , Feng Shaoqing , Su Weijie , Li Hua , Ciudad Pedro , Tremp Mathias , Zhang Yi Xin
Published: October 2017

Background The vascularization of the distal portions of transferred tissue represents the most critical factor in the success of reconstructive surgery. In recent years, indocyanine green (ICG) fluorescence imaging techniques have been applied during surgery to evaluate flap perfusion. However, this investigation has found that there is little consensus regarding the standard dose of ICG as well as the pre-operative requirements of ICG allergy testing. The aim of this study is to summarize the applications of ICG to tissue transfers and safe dosing practices and to provide insight to the possible adverse effects of ICG on flap surgery with the goal of helping clinicians apply ICG safely and efficiently to tissue transfer procedures.

Methods A literature search was performed using, Wiley InterScience, and Springer with the key words, ‘Flap,’ ‘indocyanine green,’ ‘surgery,’ and related mesh words for all publications between 2005 and 2015. Title and abstract screening was performed using predefined in- and exclusion criteria.

Results Seventy-three articles were included. These were classified as “application of ICG in flap surgery” and “the security of applying ICG in flap surgery”.

Conclusions ICG fluorescence imaging preoperatively facilitates the detection of perforators in tissue flaps with thickness <20 mm, aids in the evaluation of flap microcirculation and perfusion, and allows surgeons to select dominant cutaneous nerves while evaluating the quality of vascular anastomoses and locating thromboses. The literature also concluded that potential allergic reactions to ICG should be taken into consideration.
Surgical Outcome of Colon Interposition in Esophageal Cancer Surgery: Analysis of Risk Factors for Conduit-Related Morbidity
Authors: Lee Kanghoon , Park Seung-Il , Kim Dong , Kim Yong-Hee , Choi Se , Kim Hyeong
Published: October 2017

Background We aimed to assess the feasibility, surgical outcomes, and conduit-related complications of colon interposition in patients with esophageal cancer.

Methods Patients with esophageal cancer who underwent colon interposition for esophageal reconstruction between June 2000 and June 2013 were retrospectively reviewed.

Results A total of 67 consecutive patients (mean age, 62.2 ± 7.9 years) were enrolled. During this time period, 944 patients underwent esophageal reconstruction using gastric conduit. Twelve patients (17.9%) also received neoadjuvant chemoradiotherapy (nCRT). The median follow-up duration was 44 months (range, 1–168 months); median survival duration was 63 months (range, 1–168 months); and 3- and 5-year overall survival rates were 61.6 and 49.4%, respectively. A total of 43 patients (64.2%) experienced at least 1 postoperative morbidity. According to the Clavien–Dindo grading system, 36 patients (54%) experienced postoperative morbidity of higher than Grade III. Pulmonary complications were most commonly observed complications among the patients (18 patients, 26.9%). Anastomosis site leakage developed in 11 patients (16.4%), and 3 of these patients (6.0%) eventually experienced graft failure. On multivariate analysis, nCRT was determined as a significant risk factor for conduit-related complications (leakage, graft failure, fistula, and stricture).

Conclusion Colon interposition is associated with relatively high complication rates, whereas nCRT is associated with conduit morbidity.
Localization of Exogenous Mesenchymal Stem Cells in a Pig Model of Lung Transplantation
Authors: Piatkowski Tanja , Brandenberger Christina , Rahmanian Parwis , Choi Yeong-Hoon , Zeriouh Mohamed , Sabashnikov Anton , Wittwer Thorsten , Wahlers Thorsten , Ochs Matthias , Mühlfeld Christian
Published: October 2017

Background Mesenchymal stem cells (MSCs) have a great potential for the treatment of acute lung injury. This study provides a detailed immunohistochemical and stereological analysis of the localization and distribution of exogenous MSC in a pig model of lung transplantation after intravascular or endobronchial application.

Methods MSC derived from human bone marrow were labeled by DiI and administered intravascularly or endobronchially to the lungs of donor pigs after a period of 3 hours warm and 3 hours cold ischemia. The left lung was transplanted to a recipient pig and reperfused for 4 hours before fixation. The right donor lung was fixed for microscopic analysis directly after the ischemia time.

Results After both administration routes, a similar number of exogenous MSC was found in the lungs. Within each animal, the heterogeneity of MSC distribution was high both with respect to left and right lung as well as to the different lobes of each lung. After endobronchial application, MSC were found in alveolar and bronchial/bronchiolar lumen, whereas after intravascular administration, they were mainly observed in blood vessels.

Conclusion Although the administration of exogenous MSC is possible by endobronchial or intravascular application, it yields a heterogeneous distribution in the lungs which may warrant strategies to improve a more homogeneous distribution.
Effects of Tirofiban on Random Skin Flap Survival in Rats
Authors: Cheng Liang , Chen Tingxiang , Li Hang , Feng Zhenghua , Li Zhijie , Lin Dingsheng
Published: October 2017

Background Tirofiban is a glycoprotein IIb/IIIa receptor antagonist that is widely used clinically. In the present study, we investigated whether tirofiban promotes flap survival in rat random skin flap model.

Methods “McFarlane flaps” models were developed in 60 male rats. The rats were divided into a tirofiban-treated group (n = 30) and a saline-treated group (n = 30). The flap surviving rate was calculated 7 days after surgery. Tissue samples were collected and subjected to histopathological evaluation. Lead oxide–gelatin angiography and immunohistochemical staining analysis were taken to evaluate angiogenesis. Analysis of oxidative stress was performed by measuring the activity of superoxide dismutase (SOD) and malondialdehyde (MDA).

Results Compared with controls, the tirofiban-treated groups exhibited significantly larger mean areas of flap survival, significantly increased SOD activity, and vascular endothelial growth factor (VEGF) expression, and significantly reduced MDA level. Hematoxylin and eosin staining revealed that naringin promoted angiogenesis and inhibited inflammation.

Conclusion These findings demonstrate that tirofiban increases flap survival of random skin flaps in rats.
Projekt „Schattentage“: Möglichkeit zur
Qualitätssicherung
Authors: Meyer Heike
Published: October 2017

Qualitätssicherung in der stationären Geriatrie Mit dem Ziel, für
Defizite, Stärken und Schwächen eines Altenwohnheims zu sensibilisieren,
implementierte Ergotherapeutin Heike Meyer die Methode „Schattentage“. Damit
verbesserte sie nicht nur die Versorgung der Bewohner, sondern veränderte auch
die innere Haltung der Mitarbeiter.
Digitalisierung – IT-Systeme gewinnbringend einsetzen
Authors: Scholer Benedikt
Published: October 2017

Seit über 20 Jahren hält die Computertechnologie Einzug in die Ergotherapie. Manche Therapeuten tun sich schwer mit elektronischen Verwaltungs- und Dokumentationssystemen. Andere sind begeistert davon, papierlos arbeiten zu können. ergopraxis beleuchtet Vor- und Nachteile.
Technische Entwicklungen zur Rehabilitation der Mobilität
Authors: Dohle Christian , Müller Friedemann , Stephan Klaus
Published: October 2017

In der Rehabilitation der Mobilität nach Schlaganfall sind technisch unterstützende Verfahren seit vielen Jahren gut etabliert und evaluiert. Belastbare Wirksamkeitsnachweise liegen vor für stationäre Endeffektorgeräte und Exoskeletts sowie für Laufbandtraining mit und ohne Gewichtsentlastung. Neue technische Entwicklungen ermöglichen die frühe Vertikalisierung im funktionellen Kontext bereits auf der (Intensiv-)Station. Zudem existieren mittlerweile verschiedene mobile Exoskelette, deren dezidierte Wirksamkeit allerdings noch belegt werden muss. Im klinischen Einsatz müssen neben einer anzustrebenden hohen Zahl an Repetitionen auch motivationale Aspekte stärker betont werden. Hier bieten sich Techniken der virtuellen Realität an. Für den praktischen Einsatz im klinischen Alltag sind hygienische Aspekte zu berücksichtigen. Für alle Neuentwicklungen ist der Einsatz in einem sinnvollen und reproduzierbaren Gesamtkonzept zu definieren.
Auswirkungen der Nahaddition auf die optische Qualität von diffraktiven multifokalen Intraokularlinsen – eine Laborstudie an der optischen Bank
Authors: Tandogan Tamer , Auffarth Gerd , Liebing Stephanie , Choi Chul , Khoramnia Ramin
Published: October 2017

Ziel Analyse und Vergleich der optischen Qualität diffraktiver multifokaler Intraokularlinsen (IOL) mit unterschiedlichen Nahadditionen mithilfe einer optischen Bank im Rahmen einer Laborstudie.

Methode Die AcrySof® IQ ReSTOR® + 2.5 D SV25T0 (Alcon, USA), die AcrySof® IQ ReSTOR® + 3.0 D SN6AD1 (Alcon, USA) sowie die TECNIS® ZMA00 und ZMB00 (Abbott Medical Optics, USA) mit einer Brechkraft von 21 dpt für die Ferne wurden an der optischen Bank OptiSpheric® IOL PRO (TRIOPTICS GmbH, Wedel) untersucht. Das optische Design dieser Linsen ist ähnlich, die Modelle unterscheiden sich allerdings hinsichtlich ihrer Nahaddition: Die AcrySof IQ ReSTOR + 2.5 D hat eine Nahaddition von + 2,5 dpt, die AcrySof IQ ReSTOR + 3.0 D eine Nahaddition von + 3,0 dpt und beide TECNIS-Linsen eine Nahaddition von + 4,0 dpt. Untersucht wurden die Fläche unterhalb der Kurve der Modulationstransferfunktion (Modulation Transfer Function Area, MTFA) und die Strehl Ratio. Weiterhin wurden die Abbildungseigenschaften der IOL mithilfe von USAF-Target-Bildern (USAF: United States Air Force) qualitativ miteinander verglichen.

Ergebnis Die MTFA-Werte für den Fernfokus waren im Median 47,85/42,06/33,57 (2,5 dpt/3,0 dpt/4,0 dpt). Für den Intermediärfokus erreichten die MTFA-Werte 11,05/9,54/8,60. Die MTFA-Werte für den Nahfokus waren 20,11/29,50/33,39. Die Strehl Ratio des Fernfokus betrug 0,48/0,42/0,29. Für den Intermediärfokus war die Strehl Ratio 0,11/0,10/0,09. Die Strehl Ratio des Nahfokus betrug 0,20/0,30/0,34. Die USAF-Target-Bilder korrelierten mit diesen Messwerten.

Schlussfolgerung Für den Nahfokus erzielen die ZMA00 und ZMB00 die besten Ergebnisse, während die IQ ReSTOR + 2.5 D am schlechtesten abschneidet. Im Intermediärbereich erreichen alle IOL ähnliche Ergebnisse. Für den Fernfokus erzielt die IQ ReSTOR + 2.5 D die besten Ergebnisse. Da heutzutage diverse Nahadditionen bei diffraktiven multifokalen IOL zur Verfügung stehen, kann die Wahl der richtigen Linse individuell auf die Bedürfnisse jedes Patienten abgestimmt werden.
Ergotherapeutische Diagnostik der selbst- ständigen Lebensführung – Ist der Klient in der Lage, sich selbst zu versorgen?
Authors: Hoffmann Lena
Published: October 2017

Einkaufen, Kochen, Waschen, Telefonieren. All das gehört zu einer selbstständigen Lebensführung. Mit dem Tölzer Screening der Handlungsplanung in den erweiterten ADLs können Ergotherapeuten bereits in der Klinik einschätzen, ob Klienten ihren Alltag zu Hause wieder bewerkstelligen können.
Recovery Through Activity – Klienten in Aktivität bringen
Authors: Berding Jutta
Published: October 2017

Mangelnde Aktivitäten schränken nicht nur die Lebensqualität ein, sondern verkürzen auch die Lebenserwartung. Besonders gefährdet sind Menschen mit schweren psychischen Erkrankungen. Ein neues ergotherapeutisches Gruppenprogramm für psychisch kranke Klienten will dem etwas entgegensetzen. Sein Ziel: einen aktiveren Lebensstil anzubahnen.
Schluckstörungen bei älteren Menschen
erkennen
Authors: Reuther Sven
Published: October 2017

Steuerungsfunktion der Pflegenden Den Pflegenden in der stationären
Altenhilfe kommt bezüglich des Erkennens von Schluckstörungen eine
Steuerungsfunktion zu. Mit der PflePhagie-Skala haben sie ein gutes Instrument
zur Erfassung eines Risikos für Schluckstörungen in der Hand. So können
Pflegende leichter entscheiden, wann weitere Experten aus anderen Berufsgruppen
hinzugezogen werden müssen.
Psychische Gefährdungsbeurteilung bei Pflegenden in der
Geriatrie
Authors: Krautz Barbara
Published: October 2017

Wer ist gefährdet? Die Zahl der Pflegebedürftigen steigt. Der Alltag der
Pflegenden ist geprägt von Personal- und Zeitknappheit. Der wahrgenommene Druck
und die Unzufriedenheit mit der eigenen leistbaren Pflegequalität führen
vermehrt zu Stress und mentaler Belastung. Das Arbeitsschutzgesetz schreibt für
alle Organisationen die Durchführung einer Psychischen Gefährdungsbeurteilung
gesetzlich vor. Damit sollen Belastungsfaktoren identifiziert und gezielt
Gegenmaßnahmen ergriffen werden. Wie gehen geriatrische Einrichtungen hier am
besten vor und wie kann der Transfer in tatsächliche Maßnahmen gelingen?
Wandel in der Anti-VEGF-Therapie von neovaskulärer AMD, diabetischem Makulaödem und Ödem infolge retinalen Venenverschlusses
Authors: Grüb Matthias , Lamprakis Ioannis , Reichel Christoph
Published: October 2017

Hintergrund Seit der Einführung der Anti-VEGF-Therapie vor mehr als 10 Jahren hat sich die Behandlung von neovaskulärer AMD, diabetischem Makulaödem und Makulaödem nach retinalen Venenverschlüssen grundlegend verändert. Initial stark visusbasierte Entscheidungskriterien wurden durch die technischen Verbesserungen der optischen Kohärenztomografie mehr und mehr durch morphologische Kriterien verdrängt. Vertragsrechtliche und verwaltungstechnische Probleme wurden verbessert, jedoch vielerorts nicht vollständig behoben.

Patienten/Material und Methoden In einer retrospektiven Analyse wurden 207 Augen von 157 Patienten ausgewertet, die sich in der Zeit von Januar 2007 bis Oktober 2013 vorstellten und bei denen eine neovaskuläre AMD, ein diabetisches Makulaödem oder ein Ödem infolge eines retinalen Venenverschlusses mittels Anti-VEGF-Therapie behandelt wurde. Der Ausgangsvisus betrug 0,25 (Median).

Ergebnisse Nach initialer Anti-VEGF-Aufsättigung zeigte sich ein signifikanter Anstieg des Ausgangsvisus auf 0,32 (p < 0,001). Je schlechter der Ausgangsvisus war, desto mehr profitierten die Patienten von der Therapie (p = 0,004). Der Visusgewinn war umso besser, je mehr intravitreale Injektionen durchgeführt wurden (p = 0,002). In der überwiegend visuskontrollierten Gruppe der frühen Jahre fiel der erreichte Visus im Laufe des 1. Jahres bei durchschnittlich 3,49 intravitrealen Applikationen auf 0,05 ab. In der OCT-kontrollierten Gruppe der späteren Jahre konnte bei durchschnittlich 5,03 intravitrealen Anti-VEGF-Applikationen der Visusgewinn bei 0,32 gehalten werden. Der Visusverlauf von visus- und OCT-kontrollierter Gruppe unterschied sich signifikant voneinander (p = 0,001). Die durchschnittliche Dauer zwischen Indikationsstellung und Therapiebeginn betrug in den frühen Jahren 25,34 Tage, in späteren Jahren 5,40 Tage.

Schlussfolgerung Die überwiegend visusbasierten Entscheidungskriterien der Anti-VEGF-Therapie der ersten Jahre scheinen den morphologischen Kriterien späterer Jahre deutlich unterlegen. Vertragsrechtliche und verwaltungstechnische Probleme haben durch eine Verzögerung der Zeit zwischen Indikationsstellung und Therapiebeginn darüber hinaus zu Unterversorgung und schlechteren funktionellen Ergebnissen beigetragen.
Nanoemulsion Improves Antinociceptive Activity of HP1, a Benzopyran from Hypericum polyanthemum
Authors: Meirelles Gabriela , Bridi Henrique , Stolz Eveline , Teixeira Helder , von Poser Gilsane , Kuze Rates Stela
Published: October 2017

The impact of nanoemulsification on the antinociceptive effect of benzopyran HP1 in a mice hot plate test was investigated. For comparison, the same experiments were performed with HP1-free form. The durability of the antinociceptive effect was analyzed at 60, 120 and 180 min. The results revealed that HP1 was successfully incorporated into a nanoemulsion system, given its high solubility in the oil phase. Regarding the pharmacological effect, HP1 (15, 30, 45, and 60 mg/kg, p.o.), both forms, displayed the pattern of a bell-shaped dose-response curve. HP1-loaded nanoemulsion displayed the maximal antinociceptive effect at a lower dose than the HP1-free form. The highest effect of the free compound was observed at 45 mg/kg, while the HP1-loaded nanoemulsion displayed the same effect at 30 mg/kg. These results suggest that the observed effect might be attributable to an increase in solubility and, thus, the enhancement of compound absorption. Regarding the durability of the antinociceptive effect, the outcomes demonstrated that the HP1-free form lost its antinociceptive effect at 120 min, while the HP1-loaded nanoemulsion kept its effect until 180 min. These findings corroborate literature data, where studies have demonstrated absorption enhancement when a compound was loaded in a nanoemulsion system.
SOP Standardisiertes Vorgehen in der Diagnostik und Therapie des periokulären Basalzellkarzinoms
Authors: Kakkassery Vinodh , Heindl Ludwig
Published: October 2017

Das Basalzellkarzinom stellt den häufigsten malignen Tumor am Auge dar. Ziel des Beitrages ist es, ein systematisches und standardisiertes Vorgehen in Diagnose, Therapie und Nachsorge periokulärer Basalzellkarzinome darzustellen. Die Interpretation von klinischen Zeichen sowie die diagnostische Sicherung von Basalzellkarzinomen sind entscheidend vor der definitiven Therapieeinleitung. Die chirurgische Sanierung des Basalzellkarzinoms stellt die wichtigste Therapiemöglichkeit dar, die sich von der mikroskopisch kontrollierten Exzision im Gesunden bis hin zur anschließenden vielfältigen Deckung des Defektbefundes erstreckt. Ebenso werden alternative Therapieverfahren, wie die zielgerichtete Therapie mittels Hedgehog-Inhibitoren oder die Bestrahlung, gerade bei ausgeprägten Befunden angesprochen. Die Nachsorge des Basalzellkarzinoms stellt einen weiteren Baustein in der Patientenversorgung dar. Ein besonderer Fokus der Arbeit liegt gerade in der speziellen Beleuchtung der Sondersituation der Basalzellkarzinombehandlung am Auge sowie die Einbettung der Versorgungsoptionen in die nationalen S2-Leitlinien der Dermatologie.