bluuebunny/crossref_metadata_2025 huggingface dataset:
Homonyms, synonyms and paronyms in the logic and grammar of Late Antiquity
Authors:   St. Petersburg State University, Chernoglazov Dmitrii
Published: January 2022

The subject of this article is the interpretation of the concepts “homonym”, “synonym” and “paronym” in the logic and grammatical theory of the Late Ancient / early Byzantine period (3rd–6th c.). Within the framework of the logical tradition, the theory of homonymy, synonymy and paronymy is developed, first of all, in the commentaries to Aristotle’s “Categories” written by Porphyry, Ammonius, Simplicius, etc., within the framework of grammatical theory – in the “Art of Grammar” by Dionysius of Thrace and its Byzantine scholia to it. Analysis of these texts shows that both disciplines paid great attention to these concepts: they were embedded in a broader terminological context; their definitions were refined and detailed; various methods of classification of homonyms and paronyms were developed. Many issues have been the subject of controversy and disagreement, for example, the problem of the relationship between metaphor, analogy and homonymy, or the methods of classification of homonyms. Significant disagreements persisted between the two disciplines: from the point of view of grammar and logic, all three concepts were interpreted differently, but the interpretation of synonymy differed most clearly. Contemporaries were aware of these contradictions between logic and grammar, noted and analyzed them.
Meno's Paradox, Cognitive Blank, and Levels of Knowledge: G. Fine on Plato's Epistemology
Authors:   Institute of philosophy and law SB RAS, Volf Marina
Published: January 2022

The article provides an overview of that parts of G. Fine's books – Essays in Ancient Epistemology (OUP, 2021) and The Possibility of Inquiry: Meno's Paradox from Socrates to Sextus (OUP, 2014) – which deal with Platonic epistemology. Our task is to show the main epistemological problems that are formed around the Meno's paradox or directly depend on it, and also to present the formulations of these problems in Fine’ own version in order to make these problems well recognizable in ancient philosophical discussions for the reader. The article examines the structure and the problematic content of Menon's paradox, and the technical vocabulary of G. Fine, which allows her to formulate the problematic content of ancient epistemology. As well it examines the number of epistemological problems: the propositionality of perception in Plato, the theory of two worlds in Plato and Aristotle, as well as certain parallels between Menon and Sisyphus, which all together make it possible to show that Meno's problematics is basic, shaping the epistemology in ancient philosophy both in Plato himself and after Plato.
Metaia
Authors:   Tbilisi State University, Kobakhidze Ekaterine
Published: January 2022

It could be said with some precision, that in Antiquity the myth of the Argonauts and especially of Medea herself as a personage of this myth, has enjoyed popularity not only in Greece but also outside its territories. The first among the Italic tribes to be introduced to the personage of Medea no doubt were the Etruscans, who were the first to establish intensive contacts with the Greeks from Euboea founding a colony in Cumae, Italy. It is noteworthy that the first image of Medea in the World Art is seen on Etruscan ceramics. The paper gives detailed analyses of Etruscan olpe and other artefacts on which Medea early appears, providing a solid precondition for substantive conclusions. Some new versions of an interpretation expressed in relation to each of the artefacts on the basis of critical analysis of Etruscan archeological material, of classical texts and of previously undertaken modern research, are provided. Images of Medea in Etruscan art confirmed from the Orientalist era to the Hellenization period represent an original, local interpretation of Medea's image. Medea's magical art turned out to be familiar to the Etruscans, who were well known all throughout the Mediterranean for divination and being experts of magic. In contrast to the Greeks, they turned Medea into an object of cult worship, identifying her with the Etruscan sun god Cavatha.
Comparative assessment of quality of life in chronic spontaneous urticaria receiving second generation anti histamines: A real world study
Authors: Shah Bela , Choudhary Ankita , Jangid Neha , Mistry Deval , Shah Shikha , Kamat Shruti , Dhoot Dhiraj , Deshmukh Gaurav Anil , Barkate Hanmant
Published: January 2022

Objectives:

Chronic spontaneous urticaria (CSU) is correlated with a high detrimental effect on the quality of life (QoL). Antihistamines are the first choice drugs in the management of CSU. QoL is important in the evaluation of the efficacy of antihistamines, as these are the most commonly used in CSU.

Materials and Methods:

In this comparative, three-arm study, patients with CSU were randomized to standard dose of either bilastine, fexofenadine, or levocetirizine for a period of 4 weeks. Patients were assessed for improvement in their QoL based on chronic urticaria QoL questionnaire (CU-Q2oL) questionnaire and urticaria activity score (UAS).

Results:

Fifty-eight CSU patients were randomized to bilastine (n = 23), fexofenadine (n = 18) and levocetrizine (n = 17) groups. There was significant improvement in CU-Q2oL and UAS score in all the groups during study period. 83%, 72%, and 65% patients reported improvement in CU-Q2oL score in bilastine, fexofenadine, and levocetrizine group, respectively. Bilastine was associated with significant improvement in CU-Q2oL compared to fexofenadine and levocetrizine (P < 0.05). Mean reduction in UAS score was 86%, 77%, and 68% in bilastine, fexofenadine and levocetrizine group respectively. The difference was statistically insignificant between the groups. The CU-Q2oL total score correlated more strongly (r = 0.62; P = 0.001) with the UAS7 in bilastine group than fexofenadine (r = 0.57; P = 0.01) and levocetrizine groups (r = 0.53; P = 0.02).

Conclusion:

The results of the study proved that, in CSU patients, QoL was improved significantly with bilastine as compared to fexofenadine and levocetirizine.
Schumpeter’in kapitalizm analizi üzerine yöntemsel ve teorik bir değerlendirme
Authors: BAŞ DİNAR Gülenay
Published: January 2022

Çalışma hayatı boyunca son derece üretken bir bilim insanı olan Schumpeter, gerek kapitalizmin işleyişi ve evrimi ile ilişkili gerekse iktisadi analizin yöntemi ile ilgili çok sayıda önemli eser ortaya koymuştur. Schumpeter’in odaklandığı konular, esin kaynakları ve buna bağlı olarak benimsediği yöntemsel anlayış zaman içinde önemli ölçüde değişmiştir. Bu durum zaman zaman Schumpeter’in tutarsız ve değişken bir düşünce yapısına sahip bir iktisatçı olarak nitelendirilmesine neden olsa da Schumpeter’in çalışmaları bir bütünsellik içinde değerlendirildiğinde ortaya koyduğu teorik ve yöntemsel anlayışının bir bütün olduğu görülmektedir. Bu çalışmanın amacı Schumpeter’in kapitalizm analizini teorik ve yöntemsel açıdan incelemek ve Schumpeter’in kapitalizm analizi ile savunduğu yöntemsel anlayış arasında güçlü ve tutarlı bir ilişki olduğunu ortaya koymaktır. Bu çerçevede, çalışmada Schumpeter’in yöntem anlayışı ile ortaya koyduğu kapitalizm analizi arasında güçlü bir ilişki bulunduğu ve bu nedenle Schumpeter’in iktisadi analizini siyasal ve toplumsal analizinden yöntemsel anlayışını da teorik analizinden ayırabilmenin mümkün olmadığı düşüncesi savunulacaktır. Bu amaç doğrultusunda bu çalışma iki bölümden oluşmaktadır. Birinci bölümde Schumpeter’in benimsediği yöntemsel yaklaşımın temel özellikleri ortaya konacak, ikinci bölümde Schumpeter’in kapitalizmin işleyişi ve evrimi ile ilgili düşüncelerine yer verilecektir. Çalışma Schumpeter’in yöntem anlayışı ile kapitalizm incelemesi arasındaki ilişkinin tartışılmasıyla son bulacaktır.
Pengaruh Financing to Deposit Ratio, Non Performing Financing, dan Return on Equity Terhadap Pembiayaan Mudharabah Pada Bank Umum Syariah di Indonesia
Authors: Handoko Dodi Okri , Zulhelmy  , Tirta Dian , Risa Fitria
Published: January 2022

Penelitian ini bertujuan untuk mengetahui pengaruh Financing to Deposit Ratio (FDR), Non Performing Financing (NPF), dan Return On Equity (ROE) terhadap Pembiyaan Mudharabah pada Bank Umum Syariah di Indonesia tahun 2016-2018. Jumlah data yang digunakan adalah sebanyak 84 laporan keuangan triwulan dari 10 Bank Umum Syariah yang memenuhi kriteria sebagai sampel. Alat analisis yang digunakan dalam penelitian ini adalah SPSS versi 22. Hasil penelitian menunjukkan bahwa FDR, NPF, dan ROE secara simultan berpengaruh terhadap pembiayaan mudharabah. Besarnya pengaruh ketiga variabel independen tersebut terhadap pembiayaan mudharabah adalah 29,6% dan sisanya 70,4% dipengaruhi oleh variabel lain di luar penelitian ini. Untuk hasil secara parsial, variabel FDR dan NPF tidak berpengaruh terhadap pembiayaan Mudharabah. Sedangkan untuk variabel ROE berpengaruh positif terhadap pembiayaan Mudharabah.
METHODS AND ALGORITHM FOR ASSESSING ENTREPRENEURIAL RISKS
Authors:   Lviv Polytechnic National University, Tyrkalo Yuriy
Published: January 2022

Based on the study of theory and practice, the article reveals issues related to methods and algorithm for assessing entrepreneurial risks, as well as presents the relevant conclusions and proposals in this direction, in particular: the choice of tools for assessing (methods and algorithm) of entrepreneurial risks with proper normative and legal regulation is an important stage in the process of entrepreneurial risk management, where quantitative assessment of entrepreneurial risk is in addition to qualitative.
SUBSTANTIATION OF STRATEGIES OF DIVERSIFICATION OF ACTIVITY OF MOTOR TRANSPORT ENTERPRISE AND THEIR EXPERIMENTAL VERIFICATION
Authors:   National Transport University, Omelyanovych Oleksii , Demishkan Fedir ,   National Transport University
Published: January 2022

The study considered the main approaches to the concept of diversification. It was determined that there are different types of diversification depending on the sources of its origin, but the main groups of classification are: functional (by processes), commercial and resource. In general, the economic system can have four typical situations when a process of diversification (specialization) occurs: 1) specialization is more profitable than the possible option of diversification; 2) specialization is the only possible way of further development and existence for this economic system in specific economic conditions; 3) diversification is more profitable than specialization; 4) diversification is the only possible way of further existence and development. Diversification is especially important in conditions of uncertainty in the development of the external environment. In such situations, diversification is the only way to avoid collapse and achieve sustainable development. The firm makes several bets in the hope that at least one of them will win. Offensive motives include aggressive growth policies; financial opportunities; overcoming the limits of growth; achieving synergistic effects. Here it is necessary to determine the presence of defense motives for the use of diversification: the distribution of business risk; reduction of cyclical instability; replacement of the declining activity. In accordance with the objectives of the study for the trucking company, it is possible to propose the use of such diversification strategies as industrial diversification, which is realized through changes in the production capacity of the trucking company; marketing diversification, which will promote the positioning of the relocation service in different market segments, and competitive diversification, which should be carried out using the methods of portfolio analysis of the company's positioning in the market.
INFORMATION-ANALYTICAL PROVISION OF EFFICIENCY OF PLANT PRODUCTS
Authors:   National University of Life and Environmental Sciences of Ukraine, Сhukhlib Alla , Yashchenko Alina ,   National University of Life and Environmental Sciences of Ukraine
Published: January 2022

The article highlights the theoretical - methodological, organizational and applied aspects of the information-analytical support as a tool for managing the efficiency of crop production. The main factors that determine the functioning of the system of information and analytical support are the scope of the agricultural enterprises and its specific features, efficiency, reliability and relevance of information support. The essence of the category «efficiency» as an object of information-analytical support is revealed. Its determined that the efficiency of crop production is to optimize the yield of high quality products from each hectare of land in value terms at the rational cost of all resources per unit of output and maintaining natural ecological balance. The application of the logically constructed system of interrelated indicators of the crop production efficiency taking into account the specific of the industry will explore the causal links between competitive factors and the system of their inverse influence on the rational for the crop production development strategy. The attentation is focused on the importance of using analytical procedures that must comply with the interrelated principles of systemicity and complexity, contribute to the creation of additional analytical information, provide a reliable assessment of the efficiency of crop production, the implementation of scientifically based forecasts.
ASSESSMENT OF UKRAINE'S HUMAN CAPITAL DEVELOPMENT IN WORLD RATINGS IN CONDITIONS OF SUSTAINABLE DEVELOPMENT
Authors:   Volodymyr Dahl East Ukrainian National University, Nochka Maryna
Published: January 2022

The article is devoted to the analysis tools for assessing human capital based on world rankings in the context of sustainable development. The most famous world rankings of human capital, studied by such international organizations as the World Bank, the United Nations, the World Economic Forum, the University of Groningen in collaboration with the University of California at Davis and others, are considered. Quantifying human capital as the economic and social value of a skill set is measured through an index. Each organization makes measurements according to its own method. The application of different criteria and indicators for assessing human capital at the macroeconomic level is analyzed. The considered assessment methodologies are overwhelmingly based on statistical approaches. Analyzed the position of Ukraine in the world rankings in recent years in dynamics. It has been confirmed that these international ratings can be considered as a reflection of the state of human capital in Ukraine. Revealed quite high rating positions of Ukraine in comparison with other countries. The results allow us to conclude that there is insufficient government funding for the development of human capital. It is concluded that Ukraine needs to improve the quality of human capital as a leading factor in increasing the efficiency of the country's economy in the context of sustainable development. The study showed that the use of high-quality, highly qualified human capital leads to an improvement in the country's position in the world rankings.
MARKETING COMMUNICATION STRATEGIES OF THE ENTERPRISE IN THE CONDITIONS OF ECONOMY DIGITALIZATION
Authors:   Zaporizhzhia Polytechnic National University, Zerkal Anastasiia , Holomb Viktoriia ,   Zaporizhzhia National University
Published: January 2022

The article considers the peculiarities of the formation of marketing communication strategies of the enterprise in terms of digitalization of the economy. The main directions of mass media in the twentieth century are determined and the delimitation of modern social media is presented. The conditions of compliance of the website have been determined so that it can be considered as a part of web 2.0: the ability to independently contribute to the content of the site; User control of your own information and website design -interactive and useful. The influence of digital and mobile technologies on the peculiarities of users' communication, as well as their attitude to the interactivity of social networks is proved. The potential of social networks to support their brands, increase the customer base and promote goods and services of enterprises has been identified. It is determined that due to its popularity, social networking sites have had a significant impact on ways of social communication and as a result have changed the sales channels of enterprises. It is estimated that the number of people using social networks is growing very fast, and at the time of writing, more than 2.62 billion people are using social networking sites. The largest social networks were analyzed: Facebook, Pinterest, Twitter, LinkedIn, Instagram. Their features and advantages for both users and professional marketers of enterprises are determined. It is estimated that in 2021, 71% of the total number of Internet users were users of social networks, and this percentage is projected to increase. The most popular activity among Internet users is social networking, and it has a high level of user engagement, which has a positive impact on the sales of businesses that work with digital marketing tools. The ease and low cost of Internet marketing compared to conventional advertising has proven that businesses in all sectors of the economy can more effectively reach their target audience, and social networks help influence other potential customers, and allow businesses to get useful feedback on their product or service. Ultimately, this leads to improved products / services and customer engagement, ie improves the company's marketing communication strategies in today's digital economy.
RISK AND ENSURING THE ECONOMIC SUSTAINABILITY OF ENTREPRENEURIAL STRUCTURES
Authors:   Lviv Polytechnic National University, Tyrkalo Yuriy
Published: January 2022

The article reveals the features of risk and the specifics of ensuring the economic sustainability of entrepreneurial structures. It has been determined that the components of the economic sustainability of entrepreneurial structures are financial sustainability, production sustainability, personnel sustainability, investment sustainability, marketing sustainability, managerial sustainability, organizational sustainability, communicative sustainability, socio-psychological sustainability, innovative sustainability, environmental sustainability, technical and technological sustainability, market sustainability, sustainability of external relationships, sustainability of the institutional environment, sustainability of information support. It has been established that the procedure for managing the economic sustainability of entrepreneurial structures includes a risk factor, since the adoption of managerial decisions on issues of economic sustainability is probable. It has been established that the key factor influencing the economic sustainability of entrepreneurial structures is economic risk, which is based on internal and external sources of negative impact on the development potential of entrepreneurial structures towards its effective implementation and sustainable development in uncertain conditions. It is proved that the risk resistance of entrepreneurial structures is the main element of the overall zustainability of entrepreneurial structures and an integral characteristic of entrepreneurial structures as open socio-economic systems, which characterize the general possibilities of achieving effective and risk-free functioning. It has been established that one of the tools for creating favorable conditions for the functioning of entrepreneurial structures is risk management, the main tasks of which are to determine the object of management for a specific entrepreneurial structure, to establish the level of danger of realizing a certain risk, to determine the possible consequences and amount of damage, to assess the propensity of entrepreneurial structures to the risk of doing business activities, defining a system of priority directions for responding to a risk, developing risk management mechanisms for entrepreneurial structures. In the future, it is recommended to study the causes, consequences and components of the process of managing entrepreneurial risks.
COOPERATION BETWEEN INTERNATIONAL AND DOMESTIC NON- GOVERNMENTAL ORGANIZATIONS IN THE TRAINING OF MANAGERS AND MEMBERS OF LOCAL COUNCILS
Authors:   Kherson National Technical University, Hrytsak Liubomyr , Durman Mykola ,   Kherson National Technical University, Durman Olena ,   Kherson National Technical University
Published: January 2022

The article notes that today a key place in civil society belongs to non-governmental organizations (NGOs), as they serve as a link between citizens (business) and government. During their activities in Ukraine, international NGOs have offered and implemented a wide range of services, as well as developed and implemented various projects aimed at developing various sectors of the economy and activating civil society. One of the points of the NGO's efforts is the education of local government officials and deputies of local councils, which is especially relevant in the framework of the implementation of decentralization reform, which has been taking place in Ukraine since 2014. At the same time, deputies must have knowledge and skills in very broad areas of government, and their political literacy directly affects the success of democratic change in Ukraine, especially changes at the local level, and the dynamic socio-economic development of local communities. In this case, non-governmental organizations and non-governmental foundations come to the fore, which in close cooperation can give deputies of local councils the opportunity to learn throughout their lives and update their knowledge in the areas of governance that they need today. One such organization is the All- Ukrainian NGO Institute of Political Education (IPE), which has been conducting non-formal education activities for local government officials and local council members for more than 10 years with the support of international NGOs. Thus, in the period 2011-2018, more than 1,000 deputies of local councils and public activists from different regions of Ukraine took part in the training within the project "Strengthening Local Democracy" (supported by NED). In 2020, IPO began cooperating with another international non-governmental organization - the DOBRE Program. In 2020-2021, more than 500 people (392 deputies and 141 local government officials) took part in the training with the support of this Program. Participants in training projects can now not only better manage their own status, rights and responsibilities as people's deputies, but also know the specifics of the budget process, land and communal spheres. In addition, the training included soft-skills units aimed at training deputies to better communicate their views, defend their position, communicate effectively with opponents, voters, and more. The study concludes that international NGOs form an educational platform for local government representatives, deputies of local councils, and Ukrainian NGOs on the basis of this platform create an educational environment aimed at activating Ukrainian society, strengthening the influence of civil society on relations with the authorities, promoting Ukraine's European integration and improving the lives of Ukrainian citizens.
NATIONAL SECURITY IN THE CONTEXT OF GLOBALIZATION: A THEORETICAL ANALYSIS OF THE CONTENT
Authors:   Kherson National Technical University, Pliushch Ruslan , Filippova Viktoriia ,   Kherson National Technical University, Pronina Oksana ,   Kherson National Technical University
Published: January 2022

Globalization has become one of the factors that led to the formation of a new concept of national security, according to which it is an integral part of the system of the highest level (regional, international, global security), which is a consequence of the integration of the world community in an effort to overcome common threats and challenges. Provision of national security is the main task of the foreign policy of the state, the aim of the national security policy is protection of the state and society from external threats. It is established that national security is a process that includes various measures that guarantee the long and free existence and national (state) development, including the protection and defense of the state as a political institution, and the protection of people and the entire society, their benefits and the natural environment from threats that significantly limit its functioning or harm the benefits subject to special protection. The analysis of the process of formation and development of ideas and views on the problem of defining the essence and content of national security showed that national security acts as an extremely complex, contradictory and long-term, but very important and necessary process to ensure sustainable development of society and state, the preconditions of which were established in different historical eras. It has been proved that national security policy and strategy should define the roles and boundaries of different actors of the country's security, appropriate mechanisms of coordination of their activities and rules of interagency support. In the context of globalization, national security strategies should include a realistic assessment of the costs and sustainability of security institutions and plan their development, in addition, national security strategies and policies are not static and require periodic updating.
Polymorphism of methylenetetrahydrofolate reductase (MTHFR) folate metabolism gene and hyperhomocysteinemia in migraine
Authors: Тадтаева З.Г. , Яковлева Е.Е. , Амелин А.В.
Published: January 2022

В обзоре обсуждается роль полиморфизма гена фолатного обмена метилентетрагидрофолат-редуктазы (MTHFR), ответственного за развитие гипергомоцистеинемии в патогенезе мигрени. Изложены общие данные о полиморфизме С677 гена фолатного цикла и метаболизме гомоцистеина. Представлен патогенетический механизм развития мигрени, связанный с провоспалительными, прокоагулянтными свойствами гомоцистеина, активацией процессов окислительного стресса, эндотелиальной дисфункцией и нейрогенным воспалением при повышении концентрации этой аминокислоты. Отражены перспективы и социальная значимость имплементации данных генетических исследований в клиническую практику, их роль в прогнозировании течения мигрени и оценке риска развития осложнений, а также коррекции фармакотерапевтических подходов. Методика. Для поиска данных в базах MEDLINE, SCOPUS и Web of Science использованы поисковые запросы: МТHFR, мигрень, патофизиология, гипергомоцистеинемия, таргетная терапия.

The review discusses the role of polymorphism of the methylenetetrahydrofolate reductase (MTHFR) folate metabolism gene responsible for hyperhomocysteinemia in the pathogenesis of migraine. Data on the polymorphism of the folate cycle gene C677 and homocysteine metabolism are presented. The pathogenetic mechanism of migraine associated with proinflammatory, procoagulant properties of homocysteine and with the activation of oxidative stress, endothelial dysfunction, and neurogenic inflammation related with increased concentrations of homocysteine is described. Prospects and social significance of implementing data of genetic research into clinical practice are discussed. Included is the role of genetic research in predicting the course and complications of migraine, in assessment of risk for complications, and in pharmacotherapeutic approaches to migraine treatment. Methods. MEDLINE, SCOPUS and Web of Science databases were used to search for data: MTHFR, migraine, pathophysiology, hyperhomocysteinemia, targeted therapy
Characteristics of cortical tubers in tuberous sclerosis
Authors: Бычкова Е.В. , Дорофеева М.Ю. , Стрельников В.В. , Аношкин К.И.
Published: January 2022

Туберозный склероз - орфанное аутосомно-доминантное наследственное заболевание, причиной которого являются инактивирующие мутации в генах TSC1 или TSC2, сопровождающиеся гиперактивацией сигнального пути mTOR, отвечающего за регуляцию роста, пролиферации, выживаемости клеток, а также аутофагии. Одним из основных клинических симптомов туберозного склероза является наличие туберов в головном мозге. Данные образования характеризуются нарушениями кортикальной ламинации, появлением аномальных нейронов и выраженным глиозом. Известно, что количество кортикальных туберов коррелирует с развитием нейропсихиатрических расстройств, в том числе фармакорезистентной эпилепсии. В данной статье освещены вопросы молекулярной генетики туберозного склероза, приведена гистопатологическая характеристика кортикальных туберов, рассмотрен молекулярный механизм морфогенеза кортикальных туберов, а также приведены данные о связи этих образований с развитием неврологических проявлений и методах их лечения.

Tuberous sclerosis is an orphan autosomal dominant hereditary disease caused by inactivating mutations in the TSC1 or TSC2 genes, accompanied by hyperactivation of the mTOR signaling pathway, which is responsible for the regulation of growth, proliferation, cell survival, and autophagy. One of the main clinical symptoms of tuberous sclerosis is the formation of tubers in the brain. These formations are characterized by disorders of the cortical lamination, the appearance of abnormal neurons and severe gliosis. It is known that the presence of cortical tubers correlates with the development of neuropsychiatric disorders, including drug-resistant epilepsy. This article highlights the issues of molecular genetics of tuberous sclerosis, presents the histopathological characteristics of cortical tubers, considers mechanism of morphogenesis of cortical tubers, and also presents the data on relationship of these formations with the development of neurological manifestations and methods of their treatment.
Clinical and molecular genetic features of neurofibromatosis type
Authors: Карандашева К.О. , Макашова Е.С. , Мартьянова А.А. , Аношкин К.И. , Золотова С.В. , Стрельников В.В.
Published: January 2022

Нейрофиброматоз 2 типа - редкое генетическое заболевание, этиологическим фактором развития которого являются мутации в гене-онкосупрессоре NF2, кодирующем белок мерлин. В обзоре подробно описаны структура, функции и посттрансляционные модификации мерлина, освещены клинические особенности нейрофиброматоза 2 типа, известные клинико-генетические корреляции, а также представлена информация о сайтах связывания мерлина и о функциональном вкладе расположенных в них мутаций, что закладывает базис персонализированной терапии нейрофиброматоза 2 типа.

Neurofibromatosis type 2 is a rare genetic disorder caused by pathogenic mutations in the NF2 tumor suppressor gene which encodes a protein called merlin. This review describes the structure, functions, and post-translational modifications of merlin, highlights clinical features and known genotype-phenotype correlations of neurofibromatosis type 2, and provides information on the merlin binding sites and the functional contribution of mutations they harbor, which lays the basis for personalized therapy for neurofibromatosis type 2.
use of digital tablets eases the way to compassionate care during the COVID-19 pandemic
Authors: Herrero Belen , Weber Valentine , Kennedy Erin , Raskovic Gligorka , Timm Coleen
Published: January 2022

Objective: A patient communication program was implemented as a response to hospitals visiting restrictive policies during the COVID-19 pandemic. The aim of the program was to facilitate communication between patients and families, mainly through the use of digital tablets; thus program performance was evaluated by selecting the number of calls performed, the average call time, and the percentage of patients that used the program more than once.
Methods: A communication service for hospitalized patients who did not have access to a personal electronic device or were unable to use their electronic device was launched at different MUHC hospitals. A dedicated team of re-deployed employees was available to help patients connect with their loved ones using a hospital tablet or telephone.
Results: A total of 806 calls were performed between April and November 2020. Eighty one percent of the calls were performed during the non-visitors policy implementation, being video calls preferred over phone calls. The average call time was 15 min, 34% of the patients had a video call with their loved one more than once and 40% of the calls were performed in the intensive care unit.
Conclusion: The patient communication program can be described as a new delivery model of compassionate care. It was effective, helped reduce patients’ isolation and met the needs of family members and caregivers during the hospital non-visitors policy directed by the Ministère de la Santé et des Services Sociaux de Québec during the Covid-19 pandemic.
Aging, care and dependency in multimorbidity: how relationships affect elderly women’s homecare and health service use
Authors: Hamiduzzaman Mohammad , Torres Stacy , Fletcher Amber JoAnn , Islam M Rezaul , Greenhill Jennene
Published: January 2022

Relationships are multidimensional, and we know little about the facets of relationships in the way elderly patients’ with multimorbidity utilise homecare and health services. Gerontology literatures emphasize the importance of place of care, inequalities, availability of health services and affordability. However, the diversity of relationships and associated dependency in elderly care remain underassessed.
A qualitative study involving a demographic survey and interviews was conducted to explore relationship experiences of elderly women with multimorbidity in homecare and health services utilization. Civil Surgeon of Sylhet District in Bangladesh was contacted to recruit participants for the study, and this resulted in 33 interviews [11 staff and 22 elderly women with multimorbidity]. Three domains of Axel Honneth’s Theory of Recognition and Misrecognition [i.e. intimate, community and legal relationships] were used to underpin the study findings. Data was analysed using critical thematic discourse method. Four themes were emerged: nature of caregiving involved; intimate affairs [marital marginalization, and parent-children-in law dynamics]; alienation in peer-relationships and neighbourhood [siblings’ overlook, neighbourhood challenges, and gender inequality in interactions]; and legal connections [ignorance of rights, and missed communication]. A marginalization in family relationships, together with poor peer supports and a misrecognition from service providers, resulted in a lack of care for elderly women with multimorbidity.
Understanding the complexities of elderly women’s relationships may assist in policy making with better attention to their health and well-being support needs. Staff training on building relationships, and counselling services for family and relatives are essential to improve the quality of care for the women.
use of portraiture to foster humanistic care
Authors: Stewart Wendy A. , Gilbert Mark
Published: January 2022

It has been said that a picture says a thousand words, that art should speak for itself. Within the social sciences, there is recognition that images are not merely illustrations, but “texts” that can be read, studied and interpreted in different ways: they are visual narratives. When we look at a work of art, we respond with our own thoughts, feelings and ideas about what it communicates.
When we look at a portrait specifically, we are not just looking at a picture of an individual, we are looking at a picture of someone being looked at. It is a visual record of an interaction, as much as a likeness of the person. The artist-sitter relationship has much in common with the doctor patient relationship involving trust, attention, and an openness to ambiguity and creativity. As clinicians that are tired and feeling overwhelmed, we may objectify patients. Engaging with art can help hone our skills to consistently see the whole person. It provides freedom to sit with ambiguity and maintain curiosity and can help us become more flexible in our thinking, to hold multiple possibilities in mind at the same time. Viewing art in a group provides opportunities to understand and appreciate others’ perspectives.
Drawing on multiple portraiture projects related to pediatric epilepsy, youth mental health and dementia, this presentation will provide constructive ways in which portraiture can be used to foster humanistic, patient centred care, and to understand the power of distributed cognition.
The Results of Developmental Task Inventory(ITP) For Guidance and Counseling Services at Islamic Boarding Schools
Authors: Kusaini Utami Niki
Published: January 2022

Guidance and counseling service is useful for students in Islamic Boarding Schools but to determine service based on the requirement of students is difficult. This research purposed to describe the results ofDevelopmental Task Inventory(ITP) to help students find developmental tasks that have not been achieved. This research used survey method. The respondents of this research six classes with the amount of 445 students in two Boarding School of Yogyakarta. The results showed that the achievement of development tasks students above the average growth rate of 3.75. The task of development is not yet achieved (3.75). Based on these results, the researcher sees each class having differences in aspects of development tasks that have not been achievedand require different guidance and counseling services.
State Regulation of Fishing in Russia in the 19th – Early 20th Centurу
Authors:   Secondary School N 25, Sankin E. V. , Zinoviev V. P. ,   National Research Tomsk State University
Published: January 2022

The article, mainly based on Siberian material, examines the problem of regulation of fishing in the Russian Empire in the late 19th – early 20th century, when serious consequences of predatory, unrestricted use of natural resources became apparent to the public and local officials. There is an awareness of the need for restrictive measures at the level of regional administration and the inattention of the general imperial power structures to this issue in relation to Asian Russia. Fishermen actively opposed any regulation of the time and methods of fishing in Siberia. Fishing in Asian Russia had no restrictions until the Soviet era. The officials found justification for this primarily in the rights of the foreign population to use traditional fishing grounds. All the lands of Siberia remained officially state-owned and during the XIX century, fishing grounds were gradually transferred to tax articles. Attempts to regulate the rental relations of the aboriginal population and fishermen, undertaken by local authorities, have not yielded great results. Somewhat more important were the measures to regulate the relations of fishermen and hired workers at capitalist fishing enterprises – strezhevye sands. The resolutions of the Tobolsk provincial administration obliged fishermen to give workers special clothes and shoes, improve nutrition, meat, fish, bread, porridge, butter, kvass and tea were to be included in the workers' diet. The working day was limited to 15 hours a day. The resolutions ordered to arrange separate rooms for workers to rest, imputed polite treatment of workers and an increase in wages to 30 rubles. per season. District police officers were appointed responsible for the execution of the resolution. This kind of control made the regulations practically useless. The fishing industry of Siberia remained throughout the 19th – early 20th century a field of spontaneous regulation based on the economic traditions of the Russian and aboriginal population.
FEATURES OF REFLECTION AND STYLE OF DECISION-MAKING IN ADOLESCENTS
Authors:   M.K. Ammosov North-Eastern Federal University, Lukina Valentina S. , Grigorieva Elena V. ,   M.K. Ammosov North-Eastern Federal University
Published: January 2022

The article presents the results of a study of the features of reflection and the type of decision-making in adolescents. The sample was 60 people (55% girls, 45% boys). It were used the questionnaire «Differential Test of Reflection» (D.A. Leontiev et al.) and «Melbourne decision-making questionnaire» (T.V. Kornilova). The results showed the predominance of quasi-reflection, which manifests itself in idle speculation on insignificant life events, as well as a low level of development of systemic reflection. The preferred style of decision-making is procrastination, which means postpone solutions. Correlation analysis allowed us to confirm the hypothesis that the level of systemic reflection increases with age. At the same time, a positive correlation was found between systemic reflection and such a decision-making style as «avoidance». We assume the influence of an unaccounted variable.
Neo-classicism and the other Revivals in 1840 New Zealand: British Domestic Design in Indigenous Materials
Authors: Cottrell William
Published: January 2022

In the first decades of the nineteenth century there was an insatiable enthusiasm for the fashions of previous eras. New research has established that designs for domestic furnishings in America, Australia and New Zealand were concurrent with the latest London and Paris fashions. It may be hard to imagine, with the priorities of convict and missionary life in the Australasian colonies, that influence of some of the greatest English designers was of any importance.Furniture designs by George Hepplewhite (1788), Thomas Sheraton (1794) and Thomas Hope (1807) can be found in New South Wales, while George Smith (1826), Thomas King (1829-35) and John Loudon (1833) can be identified in New Zealand. Elements of current British style trends from thereon can be seen in colonial-made furniture as mainstream fashion. By the 1840s the rare surviving examples made of native timbers are typical of those that could be found in any English home. Evidence does survive and, with interpretation, reveals a consistent influx of modern styles into the new colonies.
Foundations of Control: New Zealand Building Legislation in the 1840s
Authors: Isaacs Nigel
Published: January 2022

The development of the "Raupo Houses Ordinance 1842" could be considered as the direct ancestor of today's "New Zealand Building Code." Limited in its scope and application, the Ordinance provided a short-term solution to what was hoped to be a short-term problem - the use of highly flammable material for house construction. It was not intended for application to the countryside, only to urban areas. To be effective, the Ordinance had to be adopted by each provincial council as covering a specific area. This occurred from 1842 (Auckland) to 1852 (Lyttelton and Christchurch). It was finally repealed in 1878. Not every province was happy with the Ordinance, with New Plymouth setting up its own "Thatch and Straw Building Ordinance." This paper will examine the intent, content and context of the Ordinance and its consequences on the development of future building controls.
The Relationship between Kitwood's Model of Needs and a Student's Music Therapy Practice in an Acute Assessment Unit for People Living with Dementia and Mental Health Issues
Authors:   , Allan Maharani
Published: January 2022

This study focused on reviewing a student's music therapy practice at an acute assessment unit for people living with dementia and mental health issues, finding links between the placement philosophy, and new ideas about practice. Kitwood's (1997) book on personhood and the needs of people who are living with dementia and other mental health issues appeared to resonate with the student music therapists' practice. This was supported by the active use of his model of needs by nursing staff at the placement. Investigations looked specifically at Kitwood's model of needs; how music therapy links with his philosophy and how interventions during practice connected to those needs. The data was draw from descriptive clinical notes using secondary analysis. The rich qualitative data was analysed using deductive and inductive methods. Findings are presented under Kitwood's model of needs, forming the five categories for the study. The main themes within these categories were then summarised and explanations given under both Kitwood's model of needs and music therapy interventions used to meet them. Though the findings are qualitative, specific to this study and not necessarily generalisable, several links within music therapy practice, and nursing practice revealed the importance and need for more person-centred individualised care programmes for patients in mental health settings.
ELUCIDACIÓN DE LA FÓRMULA ESTEQUIOMÉTRICA DE NANOHIDROTALCITAS DE Mg Y Ni SINTETIZADAS POR EL MÉTODO DE COPRECIPITACIÓN
Authors: Rodríguez Augusto , Fernández Lenys , Domínguez José , González Gema , Martínez Omar , Espinoza- Montero Patricio
Published: January 2022

Los hidróxidos dobles laminares (LDH, por sus siglas en inglés), también denominados como Hidrotalcitas (HTs), son una clase de materiales arcillosos bidimensionales conocidos por su estructura laminar única, composición versátil y propiedades de intercambio iónico. En este trabajo se reporta la determinación de la relación estequiométrica de arcillas tipo HTs sintetizadas en el laboratorio por el método de co-precipitación. El contenido de metales di y tri-valente que conforman las estructuras de las arcillas fue cuantificado por espectroscopia de absorción atómica por llama. Se sintetizaron dos tipos de HTs, Ni (HT-Ni) y Mg (HT-Mg); donde de acuerdo con los cálculos realizados la formula estequiométrica para la primera arcilla es Ni0,82Al0,18(OH)2(NO3)0,18 y Mg0,80Al0,20(OH)2(NO3)0,20 para la segunda, resultados que concuerdan perfectamente con la literatura. Las arcillas sintetizadas fueron caracterizadas por difracción de rayos X, espectroscopia FT-IR y microscopia electrónica de barrido. Los patrones de difracción de rayos X confirmaron la formación de HTs de tamaño de partícula nanométrico, donde la HT-Mg sintetizada posee mejores propiedades cristalinas.
Fotoelectroquímica en sistemas nanoestructurados: una discusión desde sus límites naturales
Authors: Vargas Ronald , León Dalia , Torres Daniel , Maimone Alberto , Cabrerizo Franco M. , Madriz Lorean
Published: January 2022

Luego de reconocer que la respuesta fotoelectroquímica depende de la yuxtaposición de fenómenos de transferencia y de recombinación de las cargas fotogeneradas, y que dichos procesos representan límites naturales al comportamiento experimental, se discutieron algunos aspectos fisicoquímicos que determinan el desempeño de una interfase semiconductor | electrolito, considerando específicamente la situación de un fotoánodo nanoestructurado. Se tomó como caso de estudio la relación entre la respuesta experimental de transferencia electrónica y la recombinación en nanotubos de TiO2, presentando estos, una modificación en la relación de fases anatasa y rutilo. Mediante el análisis de la respuesta potenciodinámica a elevados sobrepotenciales en relación a la teoría de Gärtner, además de, la cuantificación del tiempo de vida de portadores debido al decaimiento fotoluminiscente a circuito abierto (bajo sobrepotencial), resultó posible ilustrar la relación cualitativa entre la cinética de transferencia de carga y la desactivación, procesos que, siendo opuestos, determinan la respuesta de estos fotoánodos nanoestructurados.