bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of cardiac rehabilitation therapy on depressed patients with cardiac insufficiency after cardiac surgery
Authors: Zhang Wenyu , Zhu Guangjian , Li Beibei , Chen Chen , Zhu Yingzhi
Published: November 2023

This study aims to analyze the effect of cardiac rehabilitation therapy on cardiac autonomic nervous function in patients with cardiac insufficiency complicated with anxiety depression after cardiac operation to provide a reference for clinical practice. A total of 109 patients subject to cardiac operation in our hospital from January 2020 to March 2023 were enrolled as study subjects, including 50 patients who received conventional rehabilitation therapy (control group) and 69 patients who received cardiac rehabilitation therapy (research group). Before and after treatment, the left ventricular ejection fraction (LVEF) and central venous pressure (CVP) were determined, and the level of N-terminal pro-B-type natriuretic peptide (NT-proBNP) was measured. Low frequency/high frequency (LF/HF), standard deviation of normal to normal (SDNN), and root mean of successive square differences (RMSSD) were measured by a multi-lead ECG system. Self-rating Anxiety Scale (SAS), Self-rating Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI), Activity of daily living (ADL), and Barthel Index (BI) were applied for corresponding investigations, as well as the 6-min walk test (6MWT). After treatment, the research group showed higher LVEF, CVP, LF/HF, SDNN, and RMSSD, and lower NT-proBNP, SAS, and SDS than the control group (P < 0.05). Significantly elevated ADL score, BI, and 6MWT and reduced PSQI were observed in both groups after treatment, with more remarkable changes in the research group (P < 0.05). In conclusion, cardiac rehabilitation therapy effectively improved the cardiac function of patients with cardiac insufficiency complicated with anxiety and depression after the cardiac operation and alleviated their negative emotions.
lncRNA LENGA sponges miR-378 to promote myocardial fibrosis in atrial fibrillation
Authors: Wu Liting , Gao Bingjing , Shen Mengyuan , Wei Lu , Li Zhumeng , Zhuang Wenfang
Published: November 2023

miR-378 is known to suppress myocardial fibrosis, while its upstream regulators have not been identified. lncRNA LENGA is a recently identified lncRNA in cancer biology. We observed the altered expression of LENGA in atrial fibrillation (AF) patients and predicted its interaction with miR-378. We then explored the interaction between LENGA and miR-378 in AF. Angiotensin-II (Ang-II)-induced human atrial cardiac fibroblasts and human atrial muscle tissues were collected and the expression of LENGA and miR-378 was determined by RT-qPCR. The interaction between LENGA and miR-378 was analyzed through bioinformatics analysis and confirmed by RNA pulldown assay. Cell proliferation and collagen production were analyzed through in vitro assay to analyze the role of LENGA and miR-378 in MF. AF patients showed increased expression of LENGA and deceased expression of miR-378 compared to the sinus rhythm group. LENGA and miR-378 interacted with each other, while they are not closely correlated with each other. Overexpression assay showed that LENGA and miR-378 overexpression failed to affect each other’s expression. LENGA promoted collagen production and proliferation of Ang-II-induced atrial fibroblasts, while miR-378 played opposite roles. Moreover, LENGA suppressed the function of miR-378. Therefore, LENGA may sponge miR-378 to promote MF in AF.
Neuronal Population Encoding of Identity in Primate Prefrontal Cortex
Authors: Sharma K.K. , Diltz M.A. , Lincoln T. , Albuquerque E.R. , Romanski L.M.
Published: November 2023

The ventrolateral prefrontal cortex (VLPFC) shows robust activation during the perception of faces and voices. However, little is known about what categorical features of social stimuli drive neural activity in this region. Since perception of identity and expression are critical social functions, we examined whether neural responses to naturalistic stimuli were driven by these two categorical features in the prefrontal cortex. We recorded single neurons in the VLPFC, while two male rhesus macaques (Macaca mulatta) viewed short audiovisual videos of unfamiliar conspecifics making expressions of aggressive, affiliative, and neutral valence. Of the 285 neurons responsive to the audiovisual stimuli, 111 neurons had a main effect (two-way ANOVA) of identity, expression, or their interaction in their stimulus-related firing rates; however, decoding of expression and identity using single-unit firing rates rendered poor accuracy. Interestingly, when decoding from pseudo-populations of recorded neurons, the accuracy for both expression and identity increased with population size, suggesting that the population transmitted information relevant to both variables. Principal components analysis of mean population activity across time revealed that population responses to the same identity followed similar trajectories in the response space, facilitating segregation from other identities. Our results suggest that identity is a critical feature of social stimuli that dictates the structure of population activity in the VLPFC, during the perception of vocalizations and their corresponding facial expressions. These findings enhance our understanding of the role of the VLPFC in social behavior.
Prediction of the breeding value of leaf lettuce mutant lines according to the correlation between the manifestation of qualitative and quantitative traits
Authors: Kondratenko S. I. , Samovol O. P. , Kormosh S. M. , Mytenko I. M. , Poznyak O. V. , Chaban L. V.
Published: November 2023

Aim. To establish the effect of mutagenic factors on the formation of qualitative traits, defining the phenotype of the
leaf blade, and to investigate the correlation between the manifestation of these factors and the variation of quantitative
traits of breeding value in mutant lines of leaf lettuce. Methods. Non-parametric statistical and criteria of difference
for biological specimens, computational and analytical calculations, correlation analysis. Results. The comparative
analysis was conducted on the qualitative characteristics of the original leaf blade form of leaf lettuce, Zhnych variety,
alongside 14 mutant lines derived from it through the application of mutagenic agents, including dimethyl sulfate
(DMS) and its derivatives (D3MU, DMU-10А, and DMU-9) in two varying concentrations. Notably, the derivatives
of DMS exhibited superior mutagenic efficiency, leading to a four to fivefold increase in the number of mutant plant
forms compared to the reference compound DMS. Among the derivatives, D3MU proved the most effective, generat-
ing five mutant lines. In contrast, DMU-10A and DMU-9 yielded four mutant lines, while DMS produced only one
mutant line. All mutant lines exhibited distinct variations from the initial form across 17 qualitative characteristics
determining leaf blade phenotype. The analysis of Spearman’s rank correlation coefficient (rs) demonstrated weak to
moderate correlation (rs = –0.08...0.62) between the original form and mutant lines. It was determined that three lettuce
lines, namely B-7, B-22, and B-38, exhibited the most significant deviations from the initial form in term of leaf
blade qualitative traits. Furthermore, it was established that non-parametric indicators of qualitative traits expression
exhibited moderate or high correlation (rs = 0.57...0.74) with an essential quantitative trait – the duration from the
emergence of mass shoots to plant stem development in mutant lines. Conclusions. The identified correlations between
quantitative and qualitative traits provide the opportunity to predictably select mutant genotypes with extended
growth period during the early stages of lettuce plant ontogenesis in future breeding work.
Key role of phenol enzymes metabolism in the legume-rhizobial symbiosis under different water supply regimes
Authors: Nyzhnyk T. , Kots S.
Published: November 2023

The legume-rhizobium interaction induces formation of specific reactions that take metabolism in the host plant up to a new functional level, increasing its tolerance to unfavourable cultivation conditions. Our objective was to study the participation of key enzymes – phenylalanine ammonia lyase, guaiacol peroxidase, and polyphenol oxidases – in the phenol-metabolism processes and synthesis of a broad spectrum of secondary metabolites in soybean plants that have established symbiotic interactions with rhizobia of varying effectiveness during optimal and insufficient water supplies. In our studies, we used symbiotic systems of soybean and rhizobia (Bradyrhizobium japonicum) that varied in efficiency and virulence. In the period of active nitrogen fixation by soybean, from the third-true-leaf stage until budding, we created different water-supply regimes for the plants, including optimal watering at the level of 60% of full field capacity (control) and insufficient, at the level of 30% (drought). When the soybean was flowering, we recovered the optimal level of water supply (resumed watering). In the studies, we employed microbiological, biochemical, and physiological approaches. We determined the specificity of how key enzymes of the phenol metabolism such as phenylalanine ammonia lyase, polyphenol oxidase and guaiacol peroxidase in the nodules, roots, and leaves of the soybean reacted to different levels of water supply, depending on the functional efficiency of the symbiotic system involving strains of B. japonicum, varying in effectiveness and virulence. In the effective soybean-rhizobium symbiosis, there occurred insignificant changes in the activity of phenol-metabolism enzymes in the nodules, roots, and leaves during drought and after action of the stress. This evidence is that in symbiosis with effective rhizobia B1-20, soybean could realize its own defensive systems that regulate optimal functioning of phenol metabolism in dehydration conditions. In the low-effective 107 and ineffective 604k symbiotic systems of soybean, there was observed unstable dynamics of the activity of enzymes in leaves and roots, manifested in intensification or inhibition of their activity levels during drought or post-stress period. This indicates malfunctioning of the processes associated with phenol metabolism in the soybean plants. We concluded that tolerance of legume-rhizobium symbiosis to water deprivation depends on mutual involvements of the both symbiotic partners – host plant and rhizobia, their ability to fully realize the defensive systems for activation of the key enzymatic complexes taking part in regulation of phenol metabolism in plants.
Diversity of hazelnut varieties and changes in plant development during introduction in the semi-arid zone
Authors: Nazarenko M. , Simchenko O.
Published: November 2023

Global climate change provide the emergence of new opportunities for the introduction of new crops into horticultural production in the areas of insufficient precipitation. In addition to the economic aspect, it is also of interest to the biologists of the development of this plant in a qualitatively new environment.The paper considers the variability of the main traits of plant morphometry, yield for four varieties of hazelnuts in order to identify the most promising forms for cultivating in the northern part of the Steppe of Ukraine characterized by an insufficient precipitation and harsh winters. Recent milder winter conditions and a certain balance in summer droughts have made the required horticultural production possible, thereby increasing the production of hazelnuts and addressing the dietary problems of people in terms of supply of necessary vitamins and micronutrient element from hazelnuts. Promising varieties for the production plantations have been specified, the mechanisms for the yield formation have been studied. Key traits of morphometry have been identified that condition the success of a variety under insufficient humidity. These were such traits as crown volume, leaf surface area, shell thickness, average weight of one nut, weight of dry nuts, yield, kernel yield. It has been established that the yield formation on account of large, well-shaped nuts is best in terms of yield. Some aspects of yield formation and the possibility of combining different varieties, especially when more intensive growing methods are applied, are of additional interest. High variability significantly prevents the modeling of traits, for example, such as yield per tree, from being significant in terms of the formation of high yield. Semi-intensive pruning of hazelnut bushes shows its suitability for use in modern garden plantings. Variety Barselonskiy showed extremely high variability for many key parameters, which may indicate insufficient stability of this variety from a genetic point of view and the presence of a fairly significant number of hidden biotypes, which is additionally negative for cultivation in modern semi-intensive and intensive technologies. Climate change makes it possible to continue to significantly expand the area under hazelnuts due to the previously considered unfavourable southern subzones of the Forest-Steppe and the Steppe zone of Ukraine. Such new and previously unnoticed effects have been noted as fruiting in the first year in production crops, the formation of up to 5–6 inflorescences for each nut-bearing branch in the second or third year. For further investigations, it is planned to analyze the nutritional qualities of the obtained products, in terms of the composition by microelements and the presence of biologically-active substances, to trace the dynamics of the accumulation of heavy metals and the potentially associated risks.
Body-weight gains in Blaberus craniifer cockroaches and the intensity of their infection with gregarines and nematodes
Authors: Parhomenko O. V. , Lagutenko O. T. , Lebedynets N. V. , Brygadyrenko V. V.
Published: November 2023

Intestinal parasites are considered to be able to hinder growth of the host animals, reducing the extent of food metabolism, damaging the intestines’ integrity by filling it with products of their metabolism. However, a long co-evolution can mitigate the negative impact of a parasite on the host organism. To study how parasites – nematodes Cranifera cranifera (Chitwood, 1932) Kloss, 1960 (Oxyurida, Thelastomatidae) and gregarines Protomagalhaensia granulosae Peregrine, 1970 and Blabericola cubensis (Peregrine, 1970) Clopton, 2009 (Eugregarinorida, Blabericolidae) – afffect the growth rates of cockroaches, we performed an experiment on 200 larvae of Blaberus craniifer Burmeister, 1838 (Blattodea, Blaberidae), varying in weight and age. We monitored changes in their body weight, intensity of food consumption, and after the experiment we counted gregarines in the midgut and nematodes in the hindgut. As a result, we found that 100% of the cockroaches were infected with two species of gregarines and one species of nematodes. The intestines of small cockroach larvae (weighing 300–400 mg) contained 16–18 specimens of gregarines on average. Large larvae had a weak tendency towards increase in the intensity of gregarine infestation. Similarly, there occurred changes in the intensity of nematode invasion: young larvae were infected on average by 8–10 specimens of nematodes and large larvae had an average of 12–14 nematodes. At the level of tendency, nematodes were observed to enhance the cockroaches’ growth rates following increase in intensity of the parasitic infection. We found that the two groups of parasites had no effect on one another: the number of gregarines had no effect on the number of specimens of nematodes and vice-versa, the number of nematodes had no effect on the number of gregarine specimens. Perhaps, this is related to different localizations of the parasites: gregarines for most of their life feed in the small intestine, while nematodes feed in the large intestine. Therefore, growth rates of the cockroaches in our experiment have not changed due to the parasites. This indicates minimization of negative effects of gregarines in the midgut and nematodes in the hindgut on the host’s life cycle, developed over long co-evolution.
Antifungal activity of the endophytic Aspergillus against Candida albicans
Authors: Nacef H. S. , Bouguerra A. , Belhattab R.
Published: November 2023

Medicinal plants remain a reliable source of bioactive compound principles known for their proven therapeutic abilities against various infectious diseases. Endophytes, microorganisms residing within plant tissues, hold promise for producing novel metabolites with potential medical applications. This study analyzes the antagonism of endophytic fungi Aspergillus sp., isolated from medicinal plants, and their extract against Candida albicans, and their effectiveness was compared with that of a medical treatment, Phanazol 1% ointment. After isolating, purifying, and identifying endophytic fungi from the medicinal plants Lavandula officinalis, Rosmarinus officinalis, Eucalyptus bicolor and Mentha piprita, a total of ten endophytic fungi were obtained. These included two yeasts (yeast and Rhodotorula sp.), as well as eight moulds (Aspergillus sp., Aspergillus niger, Nigrospora sp., Curvularia sp., Alternaria sp., Penicillium sp.), and sterile mycelium. All these fungi were tested for their antagonism against C. albicans; using the cross-streak and disk diffusion methods for yeasts and moulds respectively, with the measurement of the diameter of the growth inhibition zone of the culture. Only the strain Aspergillus sp. and its ethyl acetate extract exhibited good activity against C. albicans, with inhibition zone widths of 27.5 and 20.3 mm, respectively. Its effectiveness is comparable to that of Phanazol 1% ointment. The use of gas chromatography mass spectrometry (GC/MS) unveiled the metabolite profiles of Aspergillus sp., enabling the recognition of 10 bioactive compounds, with butanedioic acid, kojic acid, and Cyclo L-prolyl-L-valine being the major ones, constituting 45.1%, 23.1%, and 5.1% of the total, respectively. These compounds serve as valuable platform chemicals that can be transformed into various other useful chemicals with various applications in agriculture, pharmaceuticals, food, cosmetics, and the healthcare industry. In addition to refining the active substances within this extract, it has the potential to open doors for creating novel bio-sourced medications aimed at addressing resistant opportunistic fungal or bacterial infections.
Prompt Engineering: a methodology for optimizing interactions with AI-Language Models in the field of engineering
Authors: Velásquez-Henao Juan David , Franco-Cardona Carlos Jaime , Cadavid-Higuita Lorena
Published: November 2023

ChatGPT is a versatile conversational Artificial Intelligence model that responds to user input prompts, with applications in academia and various sectors. However, crafting effective prompts can be challenging, leading to potentially inaccurate or contextually inappropriate responses, emphasizing the importance of prompt engineering in achieving accurate outcomes across different domains. This study aims to address this void by introducing a methodology for optimizing interactions with Artificial Intelligence language models, like ChatGPT, through prompts in the field of engineering. The approach is called GPEI and relies on the latest advancements in this area; and consists of four steps: define the objective, design the prompt, evaluate the response, and iterate. Our proposal involves two key aspects: data inclusion in prompt design for engineering applications and the integration of Explainable Artificial Intelligence principles to assess responses, enhancing transparency. It combines insights from various methodologies to address issues like hallucinations, emphasizing iterative prompt refinement techniques like posing opposing questions and using specific patterns for improvement. This methodology could improve prompt precision and utility in engineering.
Divisor Problem for the Greatest Common Divisor of Integers in Piatetski-Shapiro and Beatty Sequences
Authors: Srisopha Sunanta , Srichan Teerapat , Tangsupphathawat Pinthira
Published: November 2023

In this paper, we derive several asymptotic formulas for the sum of d(gcd(m,n)), where d(n) is the divisor function and m,n are in Piatetski-Shapiro and Beatty sequences.
Editorial
Authors: Paganotti Ivan , Vargas Heron
Published: November 2023

O primeiro número do volume 45 da revista Comunicação Sociedade, do Programa de Pós-Graduação em Comunicação Social da Universidade Metodista de São Paulo (PósCom-Umesp) inicia 2023 com a publicação de artigos científicos de pesquisadores de universidades públicas, privadas e confessionais de sete estados brasileiros (Rio Grande do Sul, Paraná, São Paulo, Mato Grosso do Sul, Ceará, Pernambuco e Roraima) de todas as cinco regiões, e de pesquisador internacional no Uruguai, de modo a permitir que nossa comunidade científica tenha acesso às pesquisas recentes e de impacto em nossa área de estudos comunicacionais.
A cobertura dos jogos paralímpicos Rio 2016 pelo Comitê Paralímpico Brasileiro: investigando questões de gênero
Authors: Monteiro Marcondes Ianamary , Hilgemberg Tatiane , Lange de Souza Doralice
Published: November 2023

O objetivo geral deste artigo foi analisar a cobertura dos Jogos Paralímpicos Rio 2016 realizada pela assessoria de imprensa do Comitê Paralímpico Brasileiro (CPB), verificando possíveis convergências e divergências nas retratações de atletas homens e mulheres. Os objetivos específicos foram: identificar os critérios de noticiabilidade das publicações; analisar as narrativas a respeito das/dos atletas; verificar a distribuição de publicações e imagens entre os gêneros. Coletamos as matérias publicadas no site do CPB de 01 a 24 de setembro de 2016 e realizamos uma análise quanti-qualitativa dos dados. O principal critério foi "resultados/vitórias" foi mais associado aos homens do que às mulheres. As atletas tiveram menor visibilidade e destaque nos textos e imagens. A garantia de mais espaço de qualidade para as atletas na cobertura é essencial para a legitimação do paradesporto feminino.
Approbation of the Scale of Attitudes towards Intercultural Learning in Higher Education
Authors: Бульцева Мария , Берриос Кальехас Соня Алехандра
Published: November 2023

The ability to cope with the challenges of cultural diversity is one of the key competencies that students need to develop in the contemporary world. This actualizes the question of intercultural learning and students' attitudes towards it. The study aimed at development and validation of the instrument to measure students’ attitudes towards intercultural learning. Taking into account the “sources” and processes of intercultural learning available to students, as well as the structure of the attitude, an instrument consisting of four scales were created - each of them includes three aspects of the attitudes: cognitive, affective and behavioral ones. The reliability and validity of each of the instrument were confirmed on a sample of 399 students of Russian universities using statistical procedures such as exploratory and confirmatory factor analysis, analysis of the consistency of the scales according to Cronbach's alpha and McDonald’s omega, analysis of extracted mean variance and heterotrait-monotrait ratio. It seems promising to consider various aspects of intercultural learning in further research, adapting and using the scales not only in the higher education system, but also in other contexts and age groups.
The Role of Context in Scenario-Based Tasks for Measuring Universal Skills: The Use of Generalizability Theory
Authors: Грачева Дарья
Published: November 2023

In education, much attention is paid to the development and evaluation of universal skills in schoolchildren. At the same time, the assessment of universal skills requires new test formats based on the observed actions of the student in the digital environment. Scenario-based contextual tasks serve as a promising format. However, the contextual diversity of such tasks can make it difficult to compare results obtained from different scenario tasks. This article aims to analyze the role of scenario task context in measuring two universal skills: critical thinking and communication. The work uses the methods of Generalizability Theory, which allows to analyze to what extent the results can be generalized for other contexts of scenario tasks, and how, by changing the number of indicators or scenario contexts, to ensure satisfied measurement reliability. The study is based on data from fourth-grade students who were tested with various scenario-based tasks of the “4K” instrument. The results of the analysis showed that the behavior of the test-takers differs in scenarios with different contexts, while the difficulties of the contexts are almost the same. To achieve satisfactory reliability, it is recommended to use at least two scenarios with different contexts, and the use of three or more scenarios with different contexts will reduce the number of indicators without loss of reliability. Also, the study evaluated the role of context when using alternative scenario-based tasks forms were used. The alternative forms were similar in the main problem and plot of the scenario, but differed in topic (content). Changing only the content of the scenario makes it possible to generalize the results across scenario forms, that is, alternative forms can be used interchangeably. This study demonstrates how Generalization Theory can be used to optimize the development of tasks, taking into account the requirements for measurement reliability.
Measuring Learning Progress Based on Cognitive Operations
Authors: Тарасов Сергей , Зуева Ирина , Федерякин Денис
Published: November 2023

Measuring students’ growth and change is considered one of the main ways for evidence-based development of educational systems. However, it is a non-trivial methodological task, despite the numerous approaches available for its conceptualization and statistical realization. In this article, we describe the main features of measuring students' growth and change using Item Response Theory (IRT) in detail. We then expand this approach to allow for the modeling of cognitive operations with the Linear Logistic Test Model (LLTM). We show that the synthesis of traditional IRT models for measuring growth and change with LLTM significantly enriches the interpretability of ability estimates while preserving the advantages of the traditional approach. To illustrate this approach, we use a set of monitoring tests to measure educational progress in mathematics in secondary school.
Prevalence and determinants of occupational injuries among small-scale industry workers in sub-saharan Africa. A systematic review and meta-analysis
Authors: Atalay Yibeltal Assefa , Gebeyehu Natnael Atnafu , Gelaw Kelemu Abebe
Published: November 2023

Occupational injuries are manifestations of diseases because of different exposure in the workplace like Small-Scale cement factories, tanneries, textile and/or street sweeping, and woodworkers all of which affect the health condition and productivity. In sub-Saharan Africa, several primary studies were conducted regarding the magnitude of occupational injuries with a prevalence of 68.89% in street sweepers and determinant factors with inconsistent results.

This meta-analysis aimed to the pooled prevalence of occupational injuries and their associated factors in Sub-Saharan Africa among workers working in small-Scale industries.

PubMed, African Journals Online, Google Scholar, Cochrane Library, and Direct Google were systematically searched to identify primary studies. Three authors performed data abstraction and quality assessment for each included study independently. Cochran’s Q-statistic and I-squared statistics were used to check heterogeneity. The random-effects models were used to estimate the pooled prevalence and associated factors of occupational injuries. Publication bias was checked by funnel plot and Egger’s test, and also sensitivity analyses were performed.

20 primary studies with 7,235 study participants were included in the Systematic review and meta-analysis of the pooled prevalence of occupational injuries among Small-Scale industry workers in Sub-Saharan Africa. The pooled prevalence of overall occupational injuries among Small-scale industry workers in Sub-Saharan Africa was 53.23% (95% CI= 44.71, 61.74). Training, Sleeping disturbance, and Educational level were significantly associated with occupational injuries.

In this review, the pooled prevalence of occupational injuries was high. The findings of this study dictate the need for the implementation of workplace safety measures. Special attention is required for employees with lower educational levels and training.
RELAÇÃO ENTRE DIABETES MELLITUS E COVID-19: UM ESTUDO DE REVISÃO
Authors: Martins Bruna de Almeida
Published: November 2023

Diabetes mellitus (DM) é uma síndrome metabólica e se configura como uma das doenças crônicas de maior prevalência no mundo. Em se tratando do COVID-19, tem-se que é uma doença de origem recente, causada pelo SARS-CoV-19. Dessa forma, a relação entre COVID-19 e diabetes mellitus ainda está sendo estudada, fazendo-se necessário uma investigação mais aprofundada acerca dessa ligação. Assim, o objetivo do presente estudo é identificar as relações existentes entre a DM e COVID-19, de maneira a analisar as complicações causadas à saúde de pacientes diabéticos contaminados pelo Coronavírus. O trabalho se configura como um estudo de revisão, de natureza qualitativa e quantitativa, que contou com busca de referências teóricas publicadas em bases de dados eletrônicas como Google Acadêmico, Scielo, Biblioteca Digital de Teses e Dissertações (BDTD) e PubMed, respeitando o recorte temporal de 2019 a 2022. As palavras-chave utilizadas para as buscas das produções científicas foram “diabetes e complicações ao COVID-19”, “SARS-CoV-2 e diabetes mellitus” e “relação entre diabetes mellitus e COVID-19”. As conclusões apontam que o DM é um fator de risco e indica um mau prognóstico para a COVID-19, sendo necessário então, um controle glicêmico intenso e uma boa monitorização dos pacientes portadores de DM.
PROSPECTIVE ELEMENTARY TEACHERS' AWARENESS ABOUT BIODIVERSITY: FOCUSING ON THEIR ABILITY TO IDENTIFY LOCAL FLORA
Authors: Nader Moafia , Aziz Fakhra , Jabeen Sadaf , Tabassum Rabia , Kashif Mahvish Fatima
Published: November 2023

Purpose of the study: This research aimed to investigate the awareness level of Prospective elementary teachers about the Local Flora.

Methodology: Seventy prospective elementary school teachers from the Education faculty of two universities were targeted to collect data. An ad hoc questionnaire was developed to systematically assess the ability of ECT to identify name, type, and annual/biannual/all seasons and their reasons behind climate change. Gender-based analysis was carried out.

Main Findings: The results indicate that they have little ability to identify the native flora from the habitat in which they are living. Lawrence Garden, Racecourse Park, Shalimar Garden, and the University itself were considered native flora as this is the location of the research. Little awareness of the native flora was found to be an obstacle to its teaching and therefore to its conservation.

Recommendations based on the study: It is suggested that workshops and training courses for prospective teachers should be planned to enhance their ability to identify flora which would lead to its conservation later on.
Da ponderação: um estudo sobre o artigo 489, § 2º, do Código de Processo Civil
Authors: Alfaia Fábio Lopes , Dias Eduardo Rocha , Santos Jean Carlos Pimentel dos
Published: November 2023

O artigo 489, § 2º, do Código de Processo Civil previu expressamente a utilização da ponderação ou balanceamento como meio de solução de conflitos não apenas entre princípios, mas igualmente envolvendo regras, permitindo-lhe um enquadramento dogmático e teórico que foge à sua tradicional compreensão como terceira etapa da aplicação do princípio da proporcionalidade na seara dos direitos fundamentais. Impõe-se compreender, nesse contexto, a espécie de norma jurídica pela qual se poderia enquadrar a ponderação bem como sua compreensão como meio de solução de conflitos entre princípios (proporcionalidade em sentido estrito ou balancing) e como meio de aplicação de uma regra (derrotabilidade ou defeasibility). Eminentemente descritivo e avaliativo, o presente trabalho apresentar uma visão não necessariamente nova sobre este por vezes controverso instituto, inadvertidamente alçado à condição de fonte primária do Direito e como meio de solução de conflitos como um todo.
Maria Zarębińska-Broniewska (1904–1947). Aktorka, pisarka, więzień Oświęcimia
Authors: Uljasz Adrian
Published: November 2023

Maria Zarębińska-Broniewska, the wife of Władysław Broniewski, a poet, was an actress, performing during the period of „2nd Republic” on stages of Wilno, Radom, Katowice and Warszawa. She also gained film experience by playing a few small parts in Polish films. At the outset of World War II she was performing in Lviv, then under Soviet occupation. Later she resided in the area occupied by Germans and was the prisoner of Auschwitz and Ravensbrück–Altenburg camps. After the liberation she performed in Polish Army Theater in Lodz.
She died as a result of health problems caused by her stay in camps.
She left us her literary work, of high historic, esthetic and educational value, published after World War II, such as a children’s book Children of Warszawa, a novel on Holocaust and the support provided by Poles to persecuted population, and Stories from Auschwitz, with autobiographic themes, addressed to adults.
Sabotaż w Polsce 1944/1945–1956
Authors: Romański Mirosław
Published: November 2023

The article presents the subject of resistance of the sabotage nature which was not so much known in Poland. Apart from the information about the range of the sabotage phenomenon, the Polish legislation on repression matter for these types of acts and the structure being involved in combating that phenomenon has been discussed.
The article is a monograph on the development of that interesting issue. Its chronological frames include the years 1944/1945–1956 and are in accordance with the widely accepted chronological division in the latest history. The year 1956 was a turning point in a policy of the Polish authorities. Assuming power by Gomułka, liberalization of social life, stopping the Stalinist tyranny and practices and reorganization of security services caused that the sabotage during these times was perceived in a lenient way. It was limited, although other forms of resistance were more intensive, for example anonymous letters, leaflets or strikes.
The basis of the preliminary sources of that article are materials prepared by the Ministry of Public Security and Ministry of the Interior, deposited in the Institute of National Remembrance Archive in Warsaw.
Analysis of Hospital and INA-CBG’S Rates of JKN Outpatient in Genteng Regional Public Hospital in 2021
Authors: Triyudawati Wiwik , Kustriyani Anung , Prasasti Azmi
Published: November 2023

The Government's effort improves the health status of the Indonesian people by establishing a Jaminan Kesehatan Nasional (JKN). JKN’s program was formed by Badan Penyelenggara Jaminan Sosial Kesehatan (BPJS Kesehatan). Payment of health costs by BPJS uses the Indonesian-Case Based Group (INA-CBG's) especially for advanced health care services. INA-CBG's is payment to the main health center for a predetermined service package according to the disease diagnosis category. This makes hospitals strive to continue providing quality health services to JKN patients while still controlling costs. The aim of this research is analyze the difference between the outpatient BPJS patient rates and INA-CBG's rates at the Genteng Regional General Hospital in 2021. The research method is a retrospective observational study with simple random sampling. The total sample was 400 obtained during the period January to December 2021. The results of the research showed that the hospital rates was IDR 105,995,056 and the INA-CBG's rates was IDR 89,484,300. It was known that there were three largest cost components including drugs (drugs and chronic drugs) was IDR 51,878,574 (48.70%); patient care costs was IDR 33,980,600 (24.65%); and consultation fee was IDR. 10,400,000 (9.40%). The three largest components of hospital rates included minor chronic disease procedures and dialysis procedures. The conclusion was hospital rates are greater than INA-CBG's rates.
Comparison of Blood Pressure in Hypertensive Patients with Monotherapy and Combination Antihypertensive Therapy
Authors: Ramadhani Novely Dwita , Utami Primanitha Ria , Octavia Devi Ristian , Desiani Ekanita
Published: November 2023

Background: Hypertension is a cardiovascular risk factor that is closely related to the patient's systolic and diastolic blood pressure profile. Objective: This study aims to determine the comparison of systolic and diastolic blood pressure profiles using antihypertensives in patients with cardiovascular risk factors. Method: Conducted in the period August-December 2021 on 83 patients who met the inclusion criteria, namely outpatients diagnosed with hypertension with cardiovascular risk factors, adult patients over 18 years of age, a medical record sheet, and a written prescription in full. Data analysis used the Kruskal Wallis test. Results: Shows a p value of 0.02 < 0.05 that there is a difference in systolic and diastolic blood pressure when using antihypertensive monotherapy or combination. The use of antihypertensive monotherapy is able to achieve the target of reducing systolic and diastolic blood pressure, namely amlodipine by -42.4mmHg/-11.7mmHg. Meanwhile, the combination antihypertensive that provides maximum results is a combination of 2 drugs, namely Candesartan + Hydrochlorthiazide which produces a reduction of -42.64 mmHg/-16.09 mmHg; a combination of 3 drugs: Amlodipine + Candesartan + Hydrochlorthiazide resulted in a reduction of -49 mmHg/-19.1 mmHg. Conclusion: There are differences in the profile of reducing systolic and diastolic blood pressure when using monotherapy and combination antihypertensives. The choice of monotherapy and combination can provide benefits in reducing blood pressure, tolerability and the level of compliance with the drugs consumed. Rational dose selection and drug selection in hypertensive patients is an important part in achieving successful therapy and preventing drug related problems, so pharmacists need to always monitoring blood pressure profiles as a form of monitoring the effectiveness of existing antihypertensive drugs consumed by patients.
Melaleuca leucadendra Pharmacological Network for Identifying Potential Target of Alcohol Dependence
Authors: Setiawan Risma Ayu , Jamil Ahmad Shobrun , Rofida Siti , Muchlisin M Artabah
Published: November 2023

Melaleuca leucadendra (ML) contains a compound that is potentially a candidate for alcohol dependence. Alcohol dependence is defined by desire, tolerance, anxiety with alcohol, and continuing to drink even though the consequences are dangerous. The study aims to analyze the potential of the ML compound content for alcohol dependence therapy within silico-based pharmacological chain analysis. ML compound data is obtained from the Knapsack database, screening of absorption, distribution, metabolism, and excretion (ADME) of the compounds ML with SwissADME, prediction of the protein of the target compounder ML with the Swiss TargetpPrediction, Gene cards, venny, analysis of the pharmacological network with String-DB and its visualization with Cytoscape version 3.10.0. The pathways correlated with therapy are dopamine receptors, dopamine carriers, serotonin, gamma-aminobutyric acid receptors, and toll-like receptors for known therapeutic target proteins: OPRM1, DRD2, ALDH2, ADH1B, ADH1A, ADH1C, ADH4, SLC6A3, CNR1, POMC, ARRB2, and NCS1. Alcohol-dependent therapies include alpha-Campholenal, Benzaldehyde, trans-Pinocarveol, Borneol, linalool, alfa-Terpineol, (-)-alpha-Bisabolol oxide B, alphaterpine acetate, and Caryophylla-4(148),15-dien-5alphaol.
Discovery New Drug Cycela barbata in Alcohol Use Disorder Using Pharmacological Methods
Authors: Febriyandi Nuvandaru Fajar Dzikra , Jamil Ahmad Shobrun , Muchlisin M Artabah
Published: November 2023

Alcohol use disorder (AUD) is a medical condition characterized by an impaired ability to stop or control alcohol use including conditions that some refer to as alcohol abuse, alcohol dependence, alcohol addiction, and the colloquial term, alcoholism. The aim of this research is to find the potential of grass jelly (Cyclea barbata) for treating alcohol. The method used is in silico pharmacological network analysis. Secondary metabolite compound data was obtained from the Knapsack database, prediction of the ability to penetrate the blood brain barrier using the Boiled-Egg method in SwissADME. Prediction of proteins related to C. barbata used SwisstTargetPrediction. Pharmacological network analysis using StringDB and Disease Gene methods. The screening results from KnapSack showed 18 compounds, and only three compounds, namely beta-Cyclanoline, (-)-N-Methylcoclaurine, and (+)-Coclaurine, were predicted to be able to penetrate the blood-brain barrier using Boiled-EGG. From SwissTargetPrediction, 125 proteins related to C. barbata were obtained. From pharmacological network analysis, it was found that 6 proteins were related to alcohol use disorder, namely DRD3, HTR2A, SLC6A3, DRD2, OPRM1, and SLC6A4. So it can be concluded that C. barbata has potential as a plant that can be used to treat AUD.
Mission and vision of modern universities: comparative analysis on the example of the Chinese University of Hong Kong and the University of Tokyo
Authors: Sertakova Irina N.
Published: November 2023

Universities, as dynamically developing systems, are subject to constant change. Political, economic, social, spiritual phenomena and processes influence the field of higher education. In modern society, the role of the university is perceived as a mission, which implies its special purpose. The mission statement briefly and clearly reflects the concept of the existence and development of the university. The structural elements of the mission are highlighted, its close connection with the values of state and public life is noted. The main idea of the mission is often expressed in the university motto. The ways and means of implementing the mission are comprehensively covered in the university’s program documents. Important documents are ethical codes that regulate the spiritual side of the life of the university community. The vision of its mission by the Chinese University of Hong Kong and the University of Tokyo is considered. Based on the study of both universities websites, a comparative analysis is carried out. Both common characteristic features of missions and their differences are revealed.
Interjections and interjection complexes in the plays of A.N. Ostrovsky
Authors: Du Xian
Published: November 2023

An analysis of the use of interjections and interjection complexes in the plays of A.N. Ostrovsky was carried out, whose 200th birthday is celebrated all over the world this year. The playwright’s works significantly changed the Russian theater; ordinary people, representatives of the merchant class and the lower social classes appeared on the stage. They spoke the folk language, in which dialectisms, vernacular units, proverbs, sayings, and phraseological units were widely used. There important component of folk speech are interjections. They represent a complex part of speech with contradictory lexical-semantic and grammatical properties. Among them there are units with non-standard phonetic composition. Attempts to convey such interjections by means of the alphabet lead to the use of traditional notation, which very approximately reflects their real sound appearance (ugh), which becomes the cause of ethnospecific forms of transmission of such physical phonations in different languages, and this causes difficulties in their translation. At the same time, it is hardly worth talking about a special phonetic system of interjections, since the overwhelming majority of primary units (well, ah, ah, ba, wow, alas, and many others) consist of standard phonemes of the language, and their prosody generally corresponds to the prosodic characteristics vocatives and other lingual units. Interjections are widely represented in the texts of A.N. Ostrovsky’s plays. A significant place in the speech of the characters is occupied by primary interjections, with the help of which the author reflects the diversity of feelings and experiences of the characters. Among the most frequent words in plays by A.N. Ostrovsky includes interjections, well, ah. In almost all works there are also primary interjections oh, eh, hey, etc. Secondary interjections in the plays of A.N. Ostrovsky is mainly represented by the interjectivated words God, God, Lord, used both independently and as part of interjectional constructions (God bless, God be with you, etc.). In many cases, it is not easy to draw a line between interjection and religious use of these units in the speech of characters.
“Native on Fatherland”: A. Solzhenitsyn in V. Astafiev’s view (on the material of letters and journalism)
Authors: Goncharov Petr A.
Published: November 2023

The article examines the view, assessment, interpretation of the personality scale, the direction of A. Solzhenitsyn’s work in the letters and journalism of V. Astafiev. The importance of the research is due to the attention of modern literary criticism to the historiosophical and socio-political issues of Russian prose, the necessity to research the creations of Russian literature of the 20th century in its brightest performances and assessments. The purpose of the research is an attempt to determine the similarity of aesthetic positions, which became the basis for assessing and interpreting the personality and work of A. Solzhenitsyn in the V. Astafiev’s epistolary and journalism. The publications of letters and journalism by V. Astafyev, the writer’s reaction to publication of the first story by A. Solzhenitsyn are analyzed. The main arguments of V. Astafyev’s letter in defense of A. Solzhenitsyn, the motives for applying to the Writers’ Union are considered. V. Astafyev’s reaction to the “Vermont hermit” return to Russia is considered, the scale of A. Solzhenitsyn’s personality is characterized, and his public position is assessed. As a result of the analysis, it is established that in the letters and journalism of V. Astafiev a vivid image of A. Solzhenitsyn is created as an unbending fighter, an authoritative thinker, one of the founders of village prose, a patriot of Russia. It is concluded that the creative behavior of the writer V. Astafiev is determined by the specifics of his personality, the characteristics of his marital status, and the socio-political life of Russia in the 1960s – 1990s. The scope of application of the work results is research on the modern literature, teaching literature in higher and secondary schools.