bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated multiomic approach for identification of novel immunotherapeutic targets in AML
Authors: Köhnke Thomas , Liu Xilong , Haubner Sascha , Bücklein Veit , Hänel Gerulf , Krupka Christina , Solis-Mezarino Victor , Herzog Franz , Subklewe Marion
Published: June 2022

Background

Immunotherapy of acute myeloid leukemia has experienced considerable advances, however novel target antigens continue to be sought after. To this end, unbiased approaches for surface protein detection are limited and integration with other data types, such as gene expression and somatic mutational burden, are poorly utilized. The Cell Surface Capture technology provides an unbiased, discovery-driven approach to map the surface proteins on cells of interest. Yet, direct utilization of primary patient samples has been limited by the considerable number of viable cells needed.

Methods

Here, we optimized the Cell Surface Capture protocol to enable direct interrogation of primary patient samples and applied our optimized protocol to a set of samples from patients with acute myeloid leukemia (AML) to generate the AML surfaceome. We then further curated this AML surfaceome to exclude antigens expressed on healthy tissues and integrated mutational burden data from hematologic cancers to further enrich for targets which are likely to be essential to leukemia biology. Finally, we validated our findings in a separate cohort of AML patient samples.

Results

Our protocol modifications allowed us to double the yield in identified proteins and increased the specificity from 54 to 80.4% compared to previous approaches. Using primary AML patient samples, we were able to identify a total of 621 surface proteins comprising the AML surfaceome. We integrated this data with gene expression and mutational burden data to curate a set of robust putative target antigens. Seventy-six proteins were selected as potential candidates for further investigation of which we validated the most promising novel candidate markers, and identified CD148, ITGA4 and Integrin beta-7 as promising targets in AML. Integrin beta-7 showed the most promising combination of expression in patient AML samples, and low or absent expression on healthy hematopoietic tissue.

Conclusion

Taken together, we demonstrate the feasibility of a highly optimized surfaceome detection method to interrogate the entire AML surfaceome directly from primary patient samples and integrate this data with gene expression and mutational burden data to achieve a robust, multiomic target identification platform. This approach has the potential to accelerate the unbiased target identification for immunotherapy of AML.
Multi-height micropyramids based pressure sensor with tunable sensing properties for robotics and step tracking applications
Authors: Oh Dongik , Seo Jungyeon , Kim Hang Gyeom , Ryu Chaehyun , Bang Sang-Won , Park Sukho , Kim Hoe Joon
Published: June 2022

Precise sensing of pressure is essential for various mechanical and electrical systems. The recent emergence of flexible pressure sensors has enabled novel applications, such as human–machine interfaces, soft robotics, and wearable devices. Specifically, the piezoresistive sensing scheme is widely adapted for flexible pressure sensors as it is simple and exhibits outstanding measurement sensitivity and stability. The sensing properties of piezoresistive pressure sensors mainly depends on the materials and contact morphologies at the interface. This paper proposes a flexible pressure sensor based on multi-height microstructures in which the measurement sensitivity and detection range are tunable. Such tunability is due to the sequential contact of micropyramids with different heights. The multi-height micropyramid structured PDMS layer with stamp-coated multi-walled carbon nanotubes (MWCNTs) acts as a conductive active layer and a gold interdigitated electrode (IDE) patterned polyimide (PI) layer works as the bottom electrode. The fabricated sensor exhibits a sensitivity of 0.19 kPa−1, a fast response speed of 20 ms, and a detection range of up to 100 kPa. The sensor is applied to a robotic gripper for object recognition and integrated into a shoe to track walking motions.
Chemical modification of wood induced by the traditional making procedures of bowed string musical instruments: the effect of alkaline treatments
Authors: Albano Michela , Comelli Daniela , Fiocco Giacomo , Mattonai Marco , Lucejko Jeannette Jacqueline , Zoia Luca , Colombini Maria Perla , Malagodi Marco
Published: June 2022

Over the last few decades, chemical and physical studies on bowed string musical instruments have provided a better understanding of their wooden finished surface. Nevertheless, until now only a few of them investigated the effects of the chemical pre-treatments in the traditional making procedures. Those treatments are believed to affect wood properties, its interaction with the following treatments (i.e. varnish application) and its vibro-mechanical behaviour (that may contribute to the acoustical properties of musical instruments). In this study, two traditional alkaline treatments were applied to reference samples of spruce wood, the wood commonly used to make violins’ soundboards. An integrated analytical strategy, which combines infrared spectroscopy, analytical pyrolysis coupled to gas chromatography-mass spectrometry, and gel permeation chromatography, was employed to investigate the chemical alterations of lignocellulosic polymers (cellulose, hemicellulose, and lignin). Results have shown that the selected alkaline treatments induce the partial hydrolysis of the hemicellulose chains and a slight decrease in the crystallinity of cellulose. We could also prove: (i) the cleavage of lignin-carbohydrate complexes formed by the covalent bonds between hemicellulose and lignin in spruce wood, and (ii) the partial breaking of the hydrogen bonds network in cellulose. According to the literature, the alteration of the lignin-carbohydrate complexes is responsible for changes in wood mechanical behaviour. Hence, future perspectives of this research could outline new knowledge on the vibro-mechanical behaviour of the violin soundboard and the consequent acoustics.
Evaluation of bone depth, cortical bone, and mucosa thickness of palatal posterior supra-alveolar insertion site for miniscrew placement
Authors: Nucera Riccardo , Ciancio Elia , Maino Giuliano , Barbera Serena , Imbesi Emanuela , Bellocchio Angela Mirea
Published: June 2022

Background

The use of palatal miniscrew offers the possibility to improve the effectiveness of orthodontic expansion devices. Palatal expanders supported by miniscrew can be applied with different clinical protocols. Some authors proposed the use of four palatal miniscrews during miniscrew-supported palatal expansion to maximize skeletal effects in young adults’ treatment. However, bone availability decreases in the posterior paramedian palatal regions, making the positioning of the two-posterior paramedian palatal miniscrews challenging, when it is performed avoiding nasal cavities invasion. Some authors proposed miniscrews insertion in a specific region located laterally to the palatal process of the maxillary bone, and apically relatively to the dento-alveolar process. The aim of this study was to evaluate the bone thickness, cortical bone thickness, and mucosae depth of this anatomical site that, in this study, was defined as palatal posterior supra-alveolar insertion site.

Results

The evaluation of bone availability of palatal posterior supra-alveolar insertion site at different antero-posterior levels showed that the maximum amount of total bone thickness was found between the second premolar and the first molar. At this level total bone, thickness is significantly (p < .05) greater compared to the other sagittal sites and it offers on average around 2 mm of extra bone depth for miniscrew placement. Cortical bone thickness is adequate for primary miniscrew stability. Overall, cortical bone thickness considered at different insertion sites showed significant statistically (p < .05) differences. The findings of this study showed that palatal mucosa is particularly thick with average values ranging from 4 to 7 mm, and its extension ultimately affects miniscrew length selection. Palatal mucosa thickness showed no clinically significant differences comparing different sagittal and vertical insertion sites. Data also showed that palatal mucosal thickness slightly significantly increases (p < .05) with the inclination of the insertion axis relative to the occlusal plane. Finally, study findings showed that vertical growth pattern can significantly affect considered outcomes (p < .05).

Conclusions

Palatal posterior supra-alveolar insertion site is an appropriate site for posterior insertion of palatal miniscrews. Considering high anatomical variation preliminary CBCT evaluation is important to achieve optimal miniscrew placement.
Complaints of reduced cognitive functioning during perimenopause: a cross-sectional analysis of the Japan Nurses’ Health Study
Authors: Hayashi Kunihiko , Ideno Yuki , Nagai Kazue , Lee Jung-Su , Yasui Toshiyuki , Kurabayashi Takumi , Takamatsu Kiyoshi
Published: June 2022

Background

Many women experience various symptoms during the period of menopausal transition, including complaints of reduced cognitive functioning. However, these complaints are not necessarily recognized as core menopausal symptoms. In this study, we sought to characterize subjective complaints of reduced cognitive functioning by analyzing cross-sectional data from the Japan Nurses’ Health Study (JNHS).

Methods

The JNHS 4-year follow-up questionnaire containing a 21-item climacteric symptom checklist, which included a question about “poor memory or forgetfulness”, was mailed between 2005 and 2011 to all JNHS participants, regardless of their age at the time of the survey. We estimated the prevalence of slight and severe complaints in 5-year age-groups. We used principal component analysis to explore the underlying factors among the 21 symptoms during the menopausal transition period in women aged 45–54 years at the time of the survey. We also examined risk factors for complaints using multivariable modified Poisson regression analysis.

Results

In total, 12,507 women responded to the 4-year survey. The mean age at the time of the 4-year survey was 46.5 years (range 27–82). “Poor memory or forgetfulness” showed a peak prevalence of 81.7% (severe 27.9%; slight 53.8%) at 50–54 years, and gradually decreased after 55 years. Principal component analysis indicated that “poor memory or forgetfulness” belonged to somatic symptoms and was close to psychological symptoms in women aged 45–54 years. In women aged 45–54 years, the complaint was also significantly associated with hot flashes and sweats. Multivariable modified Poisson regression analysis showed that menopausal status (uncertain and postmenopausal), less sleep (sleep of < 5 h and sleep of 5– < 6 h), night-shift work, and severe vasomotor symptoms (VMS) were significantly associated with the prevalence of severe complaints of reduced cognitive functioning in women aged 45–54 years.

Conclusions

We found that prevalence of “poor memory or forgetfulness” was highest during the menopausal transition period and among perimenopausal women. This subjective complaint was associated with somatic, psychological complaints and VMS. It may be useful for women with cognitive problems in the transition period to consider management of comorbid menopausal symptoms.
Pushing the frontiers of military medical excellence: updates, progress and future needs
Authors: Seah Jun Jie , Wang De-Yun
Published: June 2022

Since its establishment in 2014, Military Medical Research has come a long way in becoming a premier journal for scientific articles from various different specialties, with a special emphasis on topics with military relevance. The field of military medicine may be obscure, and may not be readily encountered by the typical clinician on a day-to-day basis. This journal aims not only to pursue excellence in military research, but also to keep current with the latest advancements on general medical topics from each and every specialty. This editorial serves to recap and synthesize the existing progress, updates and future needs of military medical excellence, discussing foremostly the unique traits of literature published in this journal, and subsequently presenting the discourse regarding wartime and peacetime medicine, the role of the military in a public health emergency, as well as wound healing and organ regeneration. Special attention has been devoted to military topics to shed light on the effects of Chemical, Biological, Radiological and Explosive warfare, environmental medicine and military psychiatry, topics which rarely have a chance to be discussed elsewhere. The interconnectedness between military combat and soldier physical and mental well-being is intricate, and has been distorted by pandemics such as coronavirus disease 2019 (COVID-19). This journal has come a long way since its first article was published, steadily contributing to the existing knowledge pool on general medical topics with a military slant. Only with continuous research and sharing, can we build upon the work of the scientific community, with hopes for the betterment of patient care.
To jump or not to jump: momentum of jumps in crude oil price volatility prediction
Authors: Zhang Yaojie , Wang Yudong , Ma Feng , Wei Yu
Published: June 2022

A well-documented finding is that explicitly using jumps cannot efficiently enhance the predictability of crude oil price volatility. To address this issue, we find a phenomenon, “momentum of jumps” (MoJ), that the predictive ability of the jump component is persistent when forecasting the oil futures market volatility. Specifically, we propose a strategy that allows the predictive model to switch between a benchmark model without jumps and an alternative model with a jump component according to their recent past forecasting performance. The volatility data are based on the intraday prices of West Texas Intermediate. Our results indicate that this simple strategy significantly outperforms the individual models and a series of competing strategies such as forecast combinations and shrinkage methods. A mean–variance investor who targets a constant Sharpe ratio can realize the highest economic gains using the MoJ-based volatility forecasts. Our findings survive a wide variety of robustness tests, including different jump measures, alternative volatility measures, various financial markets, and extensive model specifications.
Real-time elastography “FibroScan” compared to simple non-invasive screening tools in the assessment of liver fibrosis in non-alcoholic fatty liver patients
Authors: Shamseya Ayman Mohamed , Afify Mohamed Tamer , Fayad Hussam Ahmed Shawki , Elshafey Mohamed Mahmoud
Published: June 2022

Background and aim

Non-alcoholic fatty liver disease (NAFLD) and its subtype non-alcoholic steatohepatitis (NASH) are increasing worldwide. NASH is characterized by active liver inflammation with severe consequences including progressive fibrosis, cirrhosis, and eventually hepatocellular carcinoma. In Egypt, the prevalence of NAFLD diagnosed by ultrasound is about 65.3% in children and 62.7% in adults. Liver biopsy, the only reliable method of differentiating simple steatosis from NASH, has a major disadvantage of being an invasive procedure with various complications. Serum tests have limitations including non-specificity for liver inflammation and affection by clearance rates. This study aimed to assess the reliability of simple non-invasive tests for liver fibrosis (namely fibrosis-4 “FIB-4” score and NAFLD fibrosis score) in comparison with real-time elastography (RTE or FibroScan) in patients diagnosed with NAFLD.

Patients and methods

This observational prospective case–control study was conducted on 100 cases with NAFLD and 30 healthy subjects. All patients and controls were subjected to serological (FIB-4 score and NAFLD fibrosis score) and radiological (ultrasonography and RTE) assessments of liver fibrosis.

Results

In advanced FIB-4 score ≥ F3, there was a good correlation between the findings of the RTE and each of the FIB-4 scores (with a sensitivity of 90%, specificity of 93.3%, positive predictive value (PPV) of 60%, negative predictive value (NPV) of 98.8%, with a total accuracy of 93%), NAFLD fibrosis score (with a sensitivity of 52.6%, specificity of 93.8%, PPV of 66.7%, NPV of 89.4%, with a total accuracy of 86%), and grading of steatosis by ultrasound.

Conclusions

RTE is beneficial in diagnosing and assessing NAFLD, especially in advanced cases “F3 and beyond.”
In-situ neutron-transmutation for substitutional doping in 2D layered indium selenide based phototransistor
Authors: Guo Zhinan , Zeng Yonghong , Meng Fanxu , Qu Hengze , Zhang Shengli , Hu Shipeng , Fan Sidi , Zeng Haibo , Cao Rui , Prasad Paras N. , Fan Dianyuan , Zhang Han
Published: June 2022

Neutron-transmutation doping (NTD) has been demonstrated for the first time in this work for substitutional introduction of tin (Sn) shallow donors into two-dimensional (2D) layered indium selenide (InSe) to manipulate electron transfer and charge carrier dynamics. Multidisciplinary study including density functional theory, transient optical absorption, and FET devices have been carried out to reveal that the field effect electron mobility of the fabricated phototransistor is increased 100-fold due to the smaller electron effective mass and longer electron life time in the Sn-doped InSe. The responsivity of the Sn-doped InSe based phototransistor is accordingly enhanced by about 50 times, being as high as 397 A/W. The results show that NTD is a highly effective and controllable doping method, possessing good compatibility with the semiconductor manufacturing process, even after device fabrication, and can be carried out without introducing any contamination, which is radically different from traditional doping methods.
Strategies to Advance Equity in Cancer Clinical Trials
Authors: Guerra Carmen E. , Fleury Mark E. , Byatt Leslie P. , Lian Tyler , Pierce Lori
Published: June 2022

Cancer clinical trials are critical for testing new treatments, yet less than 5% of patients with cancer enroll in these trials. Minority groups, elderly individuals, and rural populations are particularly underrepresented in cancer treatment trials. Strategies for advancing equity in cancer clinical trials for these populations include (1) optimizing clinical trial matching by broadening eligibility criteria, screening all patients for trial eligibility, expanding the number of trials against which patients are screened, and following up on all patient matches with an enrollment invitation; (2) conducting site self-assessments to identify clinical-, patient-, provider-, and system-level barriers that contribute to low rates of clinical trial screening and enrollment; (3) creating a quality improvement plan that addresses the barriers to enrollment and incorporates the use of tools and strategies such as clinical trial checklists; workforce development and trainings to improve cultural competence and reduce unconscious bias; guides to promote community education, outreach and engagement with cancer clinical trials; screening and accrual logs designed to measure participation by demographics; models of informed consent that improve understanding; clinical trial designs that reduce accessibility barriers; use of cancer clinical trial patient navigators; and programs to eliminate barriers to participation and out-of-pocket expenses; and (4) working with stakeholders to develop both protocols that are inclusive of diverse populations’ geographic locations, and strategies to access those trials. These actions will support greater access for populations that have remained underrepresented in cancer clinical trials and thereby increase the generalizability and efficiency of cancer research.
Stuart Hall and the Absent Irish
Authors: Beatty Aidan
Published: June 2022

Stuart Hall was undoubtedly one of the key theorists of late twentieth-century British politics and one of the most important leaders in the development of a serious understanding of race and racism in British society. This short review essay examines the odd ways in which Ireland and Irishness are only nominally present—and thus, in a real sense, absent—in his voluminous writings. Given the centrality of Irishness to the deep history of race in Britain and the role played by fears of Irish terrorism in Thatcherism, both central concerns of Hall’s, this is a major lacuna. This essay offers some speculative assessments as to why Hall generally ignored Ireland and draws a connection to the broad context of the British Left, which had (and still has) similar blind spots.
A Queer Lesbian Feminist Ecopoetics
Authors: Train Emma
Published: June 2022

The author elaborates the intersection of environmental theory and queer theory through a reading of the figure of the lesbian, which scholars, like Robyn Wiegman, Valerie Traub, and Lynne Huffer, have recently used to argue for a more nuanced reconsideration of gender in contemporary queer theory and queer studies. The author argues that the burgeoning field of queer ecopoetics can offer a productive response to recent calls to forge feminism alongside queer theory. The author takes the poet Muriel Rukeyser (1913–80) as a case study for a queer, lesbian, feminist ecopoetic praxis. Through a reading of three poems, the author demonstrates that, for Rukeyser, questioning human ontological boundaries is inextricable from her exploration of queer human desire, and especially inextricable from her vision of queer futurity. Furthermore, this essay shows how queer ecopoetics offers a common ground for the beyond-human, kinship-building impulses of environmental thought and for queer theory's congruent impulses of erotic and world-building relationality (as best illustrated in José Esteban Muñoz's Cruising Utopia). The author contends that what most cogently binds ecopoetics to queer theory is a deep commitment to anti-anthropogenic ethical praxis, which parallels the ethics described by Lee Edelman as a radical challenge to the social itself.
Imaging the onset of oscillatory signaling dynamics during mouse embryo gastrulation
Authors: Falk Henning J. , Tomita Takehito , Mönke Gregor , McDole Katie , Aulehla Alexander
Published: June 2022

A fundamental requirement for embryonic development is the coordination of signaling activities in space and time. A notable example in vertebrate embryos is found during somitogenesis, where gene expression oscillations linked to the segmentation clock are synchronized across cells in the presomitic mesoderm (PSM) and result in tissue-level wave patterns. To examine their onset during mouse embryo development, we studied the dynamics of the segmentation clock gene Lfng during gastrulation. To this end, we established an imaging setup using selective plane illumination microscopy (SPIM) that enables culture and simultaneous imaging of up to four embryos (‘SPIM- for-4’). Using SPIM-for-4, combined with genetically encoded signaling reporters, we detected the onset of Lfng oscillations within newly formed mesoderm at presomite stages. Functionally, we found that initial synchrony and the first ∼6-8 oscillation cycles occurred even when Notch signaling was impaired, revealing similarities to previous findings made in zebrafish embryos. Finally, we show that a spatial period gradient is present at the onset of oscillatory activity, providing a potential mechanism accounting for our observation that wave patterns build up gradually over the first oscillation cycles.
Identification of a stretch of four discontinuous amino acids involved in regulating kinase activity of IGF1R
Authors: Qadir Bhat Aadil , Owais Ayaz Mir , Hussain Razak , Dar Mohmmad Saleem , Hossain Md Mehedi , Showket Farheen , Dar Mohd Saleem , Akhter Yusuf , Dar Mohd Jamal
Published: June 2022

IGF1R is pursued as a therapeutic target because of its abnormal expression in various cancers. Recently, we reported the presence of a putative allosteric inhibitor binding pocket in IGF1R that could be exploited for developing novel anti-cancer agents. In this study, we examined the role of nine highly conserved residues surrounding this binding pocket, with the aim of screening compound libraries in order to develop small-molecule allosteric inhibitors of IGF1R. We generated GFP fusion constructs of these mutants to analyze their impact on subcellular localization, kinase activity and downstream signaling of IGF1R. K1055H and E1056G were seen to completely abrogate the kinase activity of IGF1R, whereas R1064K and L1065A were seen to significantly reduce IGF1R kinase activity. During molecular dynamics analysis, various structural and conformational changes were observed in different conserved regions of mutant proteins, particularly in the activation loop, compromising the kinase activity of IGF1R. These results show that a stretch of four discontinuous residues within this newly identified binding pocket is critical for the kinase activity and structural integrity of IGF1R.

This article has an associated First Person interview with the first author of the paper.
Fetal cardiovascular blood flow MRI: techniques and applications
Authors: van Amerom Joshua FP , Goolaub Datta Singh , Schrauben Eric M , Sun Liqun , Macgowan Christopher K , Seed Mike
Published: June 2022

Fetal cardiac MRI is challenging due to fetal and maternal movements as well as the need for a reliable cardiac gating signal and high spatiotemporal resolution. Ongoing research and recent technical developments to address these challenges show the potential of MRI as an adjunct to ultrasound for the assessment of the fetal heart and great vessels. MRI measurements of blood flow have enabled the assessment of normal fetal circulation as well as conditions with disrupted circulations, such as congenital heart disease, along with associated organ underdevelopment and hemodynamic instability. This review provides details of the techniques used in fetal cardiovascular blood flow MRI, including single slice and volumetric imaging sequences, post-processing and analysis, along with a summary of applications in human studies and animal models.
Pure ductal adenocarcinoma of the prostate protruding into the prostatic urethra: A case report of MRI findings and literature review
Authors: Yamamoto Takahiro , Takehara Yumi , Adachi Sou , Narita Akiko , Taniguchi Natsuki , Suzuki Kojiro
Published: June 2022

Ductal adenocarcinoma of the prostate (DCa) is the histological variant of prostatic carcinoma. The macroscopic finding of DCa arising from primary duct by urethroscopy is papillary excrescences in the prostatic urethra. But the finding of MRI remains poorly understood, since there is no coherent report on the MRI finding of DCa arising from primary duct. We herein report a case of DCa arising from primary duct and forming papillary excrescences in the prostatic urethra. The patient was a male in his 70s and presented with gross hematuria a few days ago. Blood test showed elevated prostate specific antigen (PSA). Prostate MRI was performed. There were two lesions in the prostatic urethra and the right transition zone (TZ). On T2-weighted image (T2WI), the lesion in the prostatic urethra was identifiable, but the lesion in the right TZ was difficult to identify. On diffusion-weighted image (DWI), both lesions showed hyperintense signal and could be identified, and there was continuity between them. Urethroscopy was performed, there was the lesion with papillary excrescences developing from the right dorsal side of prostatic urethra. Transurethral resection of the prostate was performed. The pathological diagnosis was DCa (pure type). A review of previous literature showed that DCa had a slightly hypointense signal on T2WI. It may be difficult to identify DCa in the TZ because DCa and the TZ show similar signals on T2WI. DWI may be useful to accurately assess DCa arising from primary duct.
Evaluation of cancer outcome assessment using MRI: A review of deep-learning methods
Authors: Mazaheri Yousef , Thakur Sunitha B. , Bitencourt Almir GV , Lo Gullo Roberto , Hötker Andreas M. , Bates David D B , Akin Oguz
Published: June 2022

Accurate evaluation of tumor response to treatment is critical to allow personalized treatment regimens according to the predicted response and to support clinical trials investigating new therapeutic agents by providing them with an accurate response indicator. Recent advances in medical imaging, computer hardware, and machine-learning algorithms have resulted in the increased use of these tools in the field of medicine as a whole and specifically in cancer imaging for detection and characterization of malignant lesions, prognosis, and assessment of treatment response. Among the currently available imaging techniques, magnetic resonance imaging (MRI) plays an important role in the evaluation of treatment assessment of many cancers, given its superior soft-tissue contrast and its ability to allow multiplanar imaging and functional evaluation. In recent years, deep learning (DL) has become an active area of research, paving the way for computer-assisted clinical and radiological decision support. DL can uncover associations between imaging features that cannot be visually identified by the naked eye and pertinent clinical outcomes. The aim of this review is to highlight the use of DL in the evaluation of tumor response assessed on MRI. In this review, we will first provide an overview of common DL architectures used in medical imaging research in general. Then, we will review the studies to date that have applied DL to magnetic resonance imaging for the task of treatment response assessment. Finally, we will discuss the challenges and opportunities of using DL within the clinical workflow.
Fekete's lemma for componentwise subadditive functions of two or more real variables
Authors: Capobianco Silvio
Published: June 2022

We prove an analogue of Fekete's subadditivity lemma for functions of several real variables which are subadditive in each variable taken singularly. This extends both the classical case for subadditive functions of one real variable, and a similar result for functions of integer variables. While doing so, we prove that the functions with the property mentioned above are bounded in every closed and bounded subset of their domain. The arguments expand on those in Chapter 6 of E. Hille's 1948 textbook.
Current Hom-Lie algebras
Authors: Ben Jmaa Torkia , Makhlouf Abdenacer , Saadaoui Nejib
Published: June 2022

In this paper, we study Hom-Lie structures on tensor products. In particular, we consider current Hom-Lie algebras and discuss their representations. We determine faithful representations of minimal dimension of current Heisenberg Hom-Lie algebras. Moreover derivations, including generalized derivations, and centroids are studied. Furthermore, cohomology and extensions of current Hom-Lie algebras are also considered.
Central part interpolation schemes for a class of fractional initial value problems
Authors: Vikerpuur Mikk , Lillemäe Margus , Pedas Arvet
Published: June 2022

We consider an initial value problem for linear fractional integro-differential equations with weakly singular kernels. Using an integral equation reformulation of the underlying problem, a collocation method based on the central part interpolation by continuous piecewise polynomials on the uniform grid is constructed and analysed. Optimal convergence order of the proposed method is established and confirmed by numerical experiments.
‘I am but a fool, look you’: Will Kemp and the Performance of Welshness
Authors: Friedman Michael David
Published: June 2022

Many scholars believe that actor Will Kemp left William Shakespeare’s company in early 1599, prompting the playwright to omit Kemp’s character Falstaff from Henry V. This essay proposes that Kemp stepped down as a shareholder but remained with the Lord Chamberlain’s men as an actor through the summer and autumn of 1599, taking small parts in Julius Caesar and the role of the Welsh Captain Fluellen in Henry V. Evidence that one of Kemp’s acknowledged parts, Launce in The Two Gentlemen of Verona, was written to be performed as a figure of Welsh descent, supports this contention.
Identifying a Troupe of Italian Players in England in 1574
Authors: Pangallo Matteo
Published: June 2022

This note identifies a previously unknown document in the Rye archive of the East Sussex Record Office. The document is a letter of safe passage for a group of twelve Italian men and women written by the English ambassador to France, Valentine Dale, in June 1574. Based on the names and other details Dale provides in the letter, this note argues that the group was a troupe of Italian performers touring to England — most likely the same troupe that entertained Queen Elizabeth at Windsor and Reading in July 1574 and the people of Dover in September or October 1574.
Adaptive Sequential Experiments with Unknown Information Arrival Processes
Authors: Gur Yonatan , Momeni Ahmadreza
Published: June 2022

Problem definition: Sequential experiments that are deployed in a broad range of practices are characterized by an exploration-exploitation trade-off that is well understood when in each time period feedback is received only on the action that was selected in that period. However, in many practical settings, additional information may become available between decision epochs. We study the performance that one may achieve when leveraging such auxiliary information and the design of algorithms that effectively do so without prior knowledge of the information arrival process. Methodology/results: Our formulation considers a broad class of distributions that are informative about rewards from actions and allows auxiliary observations from these distributions to arrive according to an arbitrary and a priori unknown process. When it is known how to map auxiliary observations to reward estimates, we characterize the best achievable performance as a function of the information arrival process. In terms of achieving optimal performance, we establish that upper confidence bound and Thompson sampling algorithms possess natural robustness with respect to the information arrival process, which uncovers a novel property of these popular algorithms. When the mappings connecting auxiliary observations and rewards are a priori unknown, we characterize a necessary and sufficient condition under which auxiliary information allows performance improvement and devise an adaptive policy (termed 2UCBs) that guarantees near optimality. We use a data set from a large media site to analyze the value that may be captured by leveraging auxiliary observations in the design of content recommendations. Managerial implications: Our study highlights the importance of utilizing auxiliary information in the design of sequential experiments and characterizes how salient features of the auxiliary information stream impact performance. Our study also emphasizes the risk in processing auxiliary information using nonadaptive approaches that are predicated on correct interpretation of this information, as opposed to deploying flexible, adaptive methods.
Diversity as an independent driver of change in the NHS
Authors: Williams Maria-Nina
Published: June 2022

Consultant physician Maria-Nina Williams explores growing diversity as an independent driver of change in the NHS and emphasises the need for healthcare managers to recognise and adapt to cultural diversity in order to promote cohesion and staff wellbeing in the workplace.
DİJİTALLEŞEN KÜLTÜR YA DA KÜLTÜRÜN DİJİTALLEŞMESİ: DİJİTAL KÜLTÜR KAVRAMI
Authors: KOÇ Rezal
Published: June 2022

Kültür, kendini iletişim yoluyla var etmektedir. Toplumdaki iletişim biçimlerinin teknoloji temelli değişimi, kültürün de yeniden ele alınması gerekliliğini ortaya koymaktadır. Bugün internet ve iletişim teknolojilerinde yaşanan gelişmelerin yarattığı, özellikle de bilgisayarların ve internetin bireylerin yaşamına nüfuz etmesiyle başlayan değişim, yeni bir kültür süreci olarak görülmekte ve “dijital kültür” kavramıyla ifade edilmektedir. Dijital kültür; siber kültür, elektronik kültür, internet kültürü, sanal kültür, enformasyon kültürü gibi çok farklı isimlerle anılsa da teknolojinin bireylerin duygu ve düşüncelerini, iletişim ve etkileşim kurma biçimlerini, değer yargılarını ve tüm bunların toplamı olan kültürü önemli ölçüde şekillendirdiği fikrini tanımlayan bir kavramdır. Günümüz dijital iletişim araştırmalarının çok büyük kısmı bu temel yaklaşım üzerinden özellikle bireyin mevcut durumdaki konumuna, rollerine, değerlerine, algı ve tutumlarına odaklanmaktadır. Bu çalışmanın amacı, dijitalleşmenin geleneksel kültürü kullanarak onu yeniden mi yarattığını yoksa dijital kültür dediğimiz şeyin başlı başına yeni bir kültür alanı mı olduğunu tartışmaya açmak, öte yandan dijitalleşmenin etkisiyle bireylerin ve kültürün uğradığı dönüşümü ortaya koymaktır.
ATSIZ'IN OTANTİK TOPLUM ÜTOPYASI: BOZKURTLARIN ÖLÜMÜ
Authors: ÜNSER Halil İbrahim
Published: June 2022

Edebî eserleriyle siyasi fikirlerini aktarma ve yaşatma çabasında olan Hüseyin Nihal Atsız’ın siyasi görüşleri Türk siyasi hayatında önemli bir tartışma konusu olmuştur. Bu çalışmada Bozkurtların Ölümü romanından hareketle Atsız’ın ütopist karakteri vurgulanmakta ve bu eserinde modernizm karşıtı bir milliyetçi olarak bir otantik toplum ütopyası kurduğu fikri savunulmaktadır. Bozkurtların Ölümü’nde detayları tespit edilebilecek olan bu ütopik toplum, mevcut siyasi ortamın eleştirisi olan Dalkavuklar Gecesi’nde hicvettiği insan tiplerinin zıddı olarak yüksek ahlâkî özellikleri ile öne çıkan, doğa ve hayvanlarla barışık, sadece yaşamını sürdürmek için avlanan ve savaşan otantik insanlardan oluşmaktadır. Bu kapsamda romanda, Türkler içindeki fikir ayrılıklarının gayet objektif bir şekilde canlandırılmış olmasına rağmen, romanda tarafsızlığı bozacak şekilde ve ısrarla neden Türklerin mutlak haklı, Çinlilerin mutlak haksız olarak gösterildikleri sorusunun cevabı aranmış ve sonuç olarak Çinlilerin modern olanı temsil ettiği Türklerin ise otantik, iyi ve doğru olana karşılık geldiği sonucuna ulaşılmıştır. Bu husus Atsız’ın Türkçülüğünün, diğer milliyetçi düşüncelerden farklılaşacak şekilde, modern olana karşıtlık temelinde yükseldiğini göstermektedir.
Experimental Characterization of the Aerodynamic Wake of a High-Clearance Sprayer with Changing Operating Parameters
Authors: Paulson Ian W. P. , Gerspacher Justin , Gagnon Benjamin J. , Landry Hubert , Sumner David , Bergstrom Donald J.
Published: June 2022

Highlights

Air velocity data were measured at seven lateral positions across the width of a modern high-clearance sprayer at multiple vertical and downstream locations relative to the nozzles. Velocity components were measured in three directions.

Complex flow patterns were present behind the sprayer tractor and rear tires. An upward velocity component was measured below and downstream of the nozzles at many of the sensor locations.

Elevated turbulent kinetic energy was measured downstream of the structural elements required for reconfiguring the boom structure into the transport position.

Abstract. With growing pressure for increased efficiency and productivity on large farms throughout North America, high-clearance sprayers have become large machines that are operated at relatively high speed when applying pesticides during the growing season. Minimizing pesticide drift remains paramount to the safe and responsible operation of these machines. With the aim of both improving the understanding of high-clearance sprayer wake features, and to aid in the validation of numerical models of a full-scale sprayer using computational fluid dynamics (CFD), time-averaged velocity components and turbulent kinetic energy (TKE) in the wake of a sprayer were measured and reported during simulated field operation. Data were collected at various locations in the wake of a sprayer at two operating speeds (4 and 11 m s-1) at two boom heights. Ultrasonic anemometers were located directly behind the sprayer, immediately beside the sprayer tractor, and farther down the boom away from the influence of the tractor. Complex flow patterns were present behind the sprayer tractor and rear tires. An upward velocity component was measured below and downstream of the nozzles at many of the sensor locations. The magnitude of turbulence, upward velocity, and velocity deficit generally increased as the reference airspeed (travel speed combined with headwind contributions) increased. A lower boom height reduced the severity of these detrimental wake characteristics near the sprayer tractor; in general, a lower boom is known to reduce the potential of spray drift. Overall, this experimental study illustrates the variation in wake features behind a modern high-clearance sprayer under different operating conditions. Keywords: High-clearance sprayer, Spray drift, Turbulent wake, Ultrasonic anemometer.
CAN YOU ACCESS CULTURE? AN EVALUATION MODEL FOR THE ACCESSIBILITY OF CULTURAL LOCATIONS
Authors:   University of Rijeka, Faculty of civil engineering, Mrak Iva , Matan Cela ,   University of Rijeka, Faculty of civil engineering
Published: June 2022

Participation in social and cultural life is the right of every human being, but for some persons (with disability, chronic illness, mobility and sensory issues…) it is greatly hindered by the inaccessibility of spaces and content. This topic has recently gained importance, owing to our growing awareness of the percentage of persons with mobility problems, and particularly regarding the aging population in many countries. Moreover, for several countries, the issue of accessibility is also related to the growing importance of tourism to their economy or the presence of many persons with disabilities related to wars. This paper presents the research on the evaluation of the accessibility of cultural locations (urban sites, museums, parks, theatres, etc.) through in-depth interviews and surveys with representatives of persons with disabilities, chronic illness, mobility and sensory issue and mental health issues, and by creating an evaluation multicriteria model with guidelines based on these inputs. The results reveal that while it is possible to evaluate the flow and content of cultural activities, there are problems of inaccessibility and lack of awareness among the general and professional public.
PERFORMANCE MANAGEMENT IN CIVIL ENGINEERING: A SYSTEMATIC LITERATURE REVIEW
Authors:   University of Rijeka, Faculty of civil engineering, Marović Ivan , Hanak Tomaš ,   Brno University of Technology, Faculty of Civil Engineering, Plaum Stefan ,   University of Applied Sciences Wiesbaden, Architecture & Civil Engineering at Hochschule RheinMain
Published: June 2022

The construction industry is generally one of the fundamental industries of a country, weighing between 5 to 10% of the gross domestic product. Rapid changes in the construction environment require a great deal of effort for a company or project manager to maintain the project successfully. To do so, applying performance management is of crucial importance. Therefore, a systematic literature review was conducted to detect new trends and highlight the evolvement of this research topic. The conducted bibliometric analysis resulted in 1240 documents published in Scopus and Web of Science databases in the period from 2000–2021. The bibliometric indicators, network citations, and multivariate statistical analysis were obtained using JabRef, OpenRefine, Excel, and VOSviewer tools. The co-occurrence analysis showed three keywords clusters as current research hotspots that may be considered as potential research topics in the future: (1) value management in the construction industry, (2) organisation innovation and knowledge management in a particular company, and (3) project management tools and techniques for a particular construction project.
LABORATORY MODEL DESIGN FOR DEEP SOIL MIXING METHOD
Authors:   Eskişehir Technical University, Department of Civil Engineering, Turkey, Onur Mehmet İnanç , Bıçakcı Mert ,   Eskişehir Technical University, Department of Civil Engineering, Turkey, Kardoğan Pınar Sezin Öztürk ,   Gazi University, Faculty of Technology, Turkey, Erdağ Ahmet ,   Gazi University, Faculty of Technology, Turkey, Aghlmand Majid ,   Eskişehir Technical University, Department of Civil Engineering, Turkey
Published: June 2022

One of the most critical problems in the construction sector is the inadequate bearing capacities of subsoils. To solve this problem, various soil improvement methods are employed. Soil improvement is defined as the improvement in soil properties to the desired level by using various methods when the soil is not suitable for superstructure loads. Various types of soil improvement methods exist, and their application depends on the construction site, soil properties, earthquake zone, application time, and cost. One of the most widely used methods recently is the deep soil mixing method. In this study, a laboratory-scale deep soil mixing device is first developed; subsequently, the effects of injection pressure, mixing time, and dosing parameters on application are investigated. Deep soil mixing columns are prepared using different injection pressures, mixing times, and dosages and then subjected to the unconfined compression test. Results show that the effects of injection pressure, cement dosage, and mixing time on the unconfined compressive strength of deep soil mixing samples vary based on the initial soil properties.
Three dimensional truncated-hexagonal-pyramid vertical InGaN-based white light emitting diodes based on β-Ga2O3
Authors: Zhao Jie , Yin Yu , Chen Renfeng , Zhang Xiang , Ran Junxue , Long Hao , Wang Junxi , Wei Tongbo
Published: June 2022

In this Letter, we describe the fabrication of three dimensional (3D) truncated-hexagonal-pyramid (THP) vertical light emitting diodes (VLEDs) with white emission grown on β-Ga2O3 substrate. In the 3D n-GaN layer, it is noted that the longitudinal growth rate of the 3D n-GaN layer increases as the flow rate of N2 decreases and H2 increases. Moreover, the 3D THP VLED can effectively suppress the quantum-confined Stark effect (QCSE) compared with planar VLEDs due to the semipolar facets and strain relaxation. Thus, the internal quantum efficiency (IQE) of the 3D THP VLED has been doubled and the V-shaped pits have been greatly reduced. In particular, the 3D THP VLED enables multi-wavelength emission (448.0 nm and 498.5 nm) and also shows better light extraction efficiency (LEE), which presents an effective way for the realization of phosphor-free white LED devices.