bluuebunny/crossref_metadata_2025 huggingface dataset:
Educational Game Tools to Improve the Language Development of Children Aged 5-6 Years
Authors: Rahmita Nelly , Khadijah Khadijah , Mutiara Yolanda
Published: January 2024

The lack of teacher creativity in using educational game tools has limited costs and a lack of teacher knowledge in early childhood education causes a learning medium. This research aims to determine educational game tools that can improve the language development of children aged 5-6 years. The research methodology used was library research. The research results show that educational game tools are not only able to improve language development but other developments are also stimulated, such as children's cognitive and social development. Data obtained from relevant previous research results through game tools, such as toy telephones (can telephones), word cards (flashcards), hand puppets, and posters, can improve the development of children aged 5-6. Therefore, this research makes it easier for readers to learn about educational game tools that can enhance language development in early childhood and can be used as a reference for PAUD educational institutions that need them.
Si Cantik Bunga Telang (Clitoria Ternatae L.) Untuk Mengatasi Diabetes Mellitus
Authors: Kusuma Eka Wisnu , Anggraini Devina Ingrid , Semartini Atur
Published: January 2024

Diabetes mellitus merupakan suatu penyakit tertua yang dikenal masyarakat, penyakit ini sangat kompleks yang melibatkan kelainan metabolisme karbohidrat, protein dan lemak.. Tujuan dari kegiatan pengabdian kepada masyarakat adalah Untuk memberikan edukasi mengenai bahan alam yang dapat diaplikasikan dalam kehidupan sehari-hari khususnya terapi herbal bagi pasien penderita diabetes mellitus di prolanis Klub Dadi Waras klaten. Rangkaian kegiatan meliputi pengisian pre-test, penyuluhan mengenai penatalaksanaan diabetes melitus, workshop pembuatan seduhan bunga telang, pelatihan mengenai proses produksi dan keberlangsungan pengelolaan tanaman bunga telang serta pengisian post-test dan kuisioner. Evaluasi telah dilakukan sesudah kegiatan pengabdian. ada pengaruh pemberian materi penyuluhan dan workshop terhadap peningkatan pengetahuan anggota prolanis.
Des tombeaux aux cités, genèse d’une culture de la sécurité le long du Moyen Euphrate dans le premier tiers du III e millénaire avant notre ère
Authors: Butterlin Pascal
Published: January 2024

La compétition entre les cités Etats mésopotamiennes du III e millénaire est un fait bien connu. Mari a joué dans le « grand jeu » des puissances mésopotamiennes un rôle très particulier à la charnière de diverses cultures qui chacune ont développé une conception particulière de leur sécurité et de sa place dans la fabrique urbaine et sociale. Divers documents issu des fouilles sur le site permettant de mesurer l’originalité d’une culture martiale, qui a connu des mutations majeures au fil du III e millénaire avant notre ère.
Harvesters all: Closing devices on reverses of archaic Ur sealings (2900–2700 BC)
Authors: Charvát Petr
Published: January 2024

I intend to study the closing devices impressed into reverses of the archaic sealings excavated by the Leonard Woolley expedition (1922–1934) at the Sumerian city of Ur. I will focus on the question how these devices guaranteed safety of the contents of the sealed entities and objects. I will then compare my findings with data from similar functional contexts.
Garder et protéger à Nuzi
Authors: Lion Brigitte
Published: January 2024

Qu’y avait-il à garder ou protéger dans le royaume d’Arraphe ? L’examen du verbe /naṣāru/, « garder, protéger » et de ses dérivés (/maṣṣaru/, /maṣṣartu/) devrait aider à répondre à la question : de la protection physique des individus, y compris en cas de conflit, à la garde des portes de la ville ou à la surveillance de biens pouvant tenter des voleurs, on tentera de voir comment les habitants de Nuzi considéraient sécurité et insécurité.
Adsorption of Cu (II) ions from aquatic environment using pre-irradiated Ethylene Tetrafluoroethylene Film
Authors: Sultana Shahnaz , Sikder S. M. Mobin , Rahman Nazia , Sardar MD. Nabul , Sen Sapan Kumar , Rini Shakila Satter , Mila Mim Mostakima
Published: January 2024

Although copper (Cu) is a very beneficial metal, having too much of it in the body can cause lung issues, severe anemia, nausea, and vomiting. In order to extract Cu (II) ions from aqueous solution, an adsorbent was constructed in this study employing pre-irradiation grafted Ethylene tetrafluoroethylene (ETFE) film. The grafting method was used to binary monomers of sodium styrene sulfonate (SSS) and acrylic acid (AA), where NaCl served as an additive. The grafted polymer was also subjected to studies of tensile strength, water uptake, surface area extension, Scanning Electron Microscopy (SEM), and Fourier Transform Infrared spectroscopy (FTIR). The adsorption of Cu (II) was investigated with respect to pH, starting metal ion concentrations, contact time, monomer concentrations, and temperature. With 50 kGy of radiation dose, 4% NaCl, and 30% of monomer solution (SSS:AA = 1:2) in water generated the highest graft yield of 470%. The maximum adsorption capacity (412 mg g−1) was discovered with an initial concentration of 2500 mg L−1, a pH of 4.86, and a contact time of 24 h at room temperature (25 ℃). A monolayer adsorption was recommended by the good linking between experimental data and the Langmuir Isotherm Model. The kinetic adsorption data closely fitted with the pseudo-second-order reaction. Due to its increased adsorption capacity and reusability, the synthesized new grafted polymer can be considered an efficient adsorbent for Cu (II) removal from wastewater.
Diálogo con Juan Martín Prada
Authors: Martín Prada Juan , Vertedor José
Published: January 2024

Dialogamos con Juan Martín Prada, experto en arte y cultura digital, centrándonos en las reflexiones extraídas de su más reciente obra, "Teoría del Arte y Cultura Digital", así como de la ponencia titulada "La creación artística visual frente a los retos de la inteligencia artificial"(Granada, 4 de Octubre de 2023). Esta última fue la conferencia inaugural del Máster en Producción e Investigación en Arte de la Universidad de Granada. La conversación destaca las complejidades éticas, filosóficas y culturales que surgen en la intersección entre la inteligencia artificial y la creación artística en la sociedad contemporánea. Exploramos las profundas implicaciones de la inteligencia artificial (IA) en la cultura visual y la creación artística, sumergiéndonos en su impacto en la memoria visual colectiva, lahistoriografía y las nuevas posibilidades generadas por la participación masiva gracias a la accesibilidad de la IA en la creación de imágenes. Finalmente, se abordan las importantes cuestiones éticas y filosóficas asociadas con la presencia de la IA en la creación artística. Se destaca la relevancia de la educación en estas tecnologías y la necesidad de reflexionar sobre su impacto en la sociedad y en la subjetividad individual. La entrevista proporciona una visión integral de las dinámicas actuales entre la inteligenciaartificial y la esfera artística, resaltando su influencia en múltiples aspectos de nuestra cultura visual contemporánea.
Bitwa Warszawska 1920 r. w serwisie informacyjnym „Ilustrowanego Kuriera Codziennego” (w setną rocznicę „Cudu nad Wisłą”)
Authors: Bańdo Adam
Published: January 2024

„Cud nad Wisłą” z 1920 roku, jak powszechnie przyjęto określać decydującą bitwę w wojnie polsko- -bolszewickiej, urósł do rangi symbolu i mitu odradzającej się po 123 latach niewoli Rzeczypospolitej. Ów mit założycielski nowego, niepodległego państwa, pomijając rzetelne naukowe opracowania historyczne, narodził się i został upowszechniony w swej „mitycznej” postaci głównie przez autorów wspomnień, uczestników wojny polsko- -sowieckiej 1919–1921, oraz w pewnym stopniu również przez Kościół katolicki. Analiza relacji prasowych, sporządzona w oparciu o serwis informacyjny najpopularniejszego dziennika „Ilustrowanego Kuriera Codziennego” posłużyła autorowi do przedstawienia dramatycznego „obrazu” wydarzeń odbieranych z punktu widzenia czytelnika dziennika. Obejmuje on okres bezpośrednio przed wybuchem konfliktu polsko-sowieckiego, ale głównie relacjonuje, w ujęciu „dzień po dniu”, przebieg zdarzeń (opartych na doniesieniach prasowych) z czasu kulminacyjnej bitwy, tj. 13–15 sierpnia i dalej do numeru z 27 sierpnia 1920 roku, gdy w „IKC” ukazują się informacje o zakończeniu decydującej batalii (datowane na 25 sierpnia 1920 r.). Wobec wielości informacji autor z oczywistych względów ograniczył się do wybranych przykładów odzwierciadlających punkt widzenia prasoznawcy a nie historyka. Artykuł uzupełniono analizą okolicznościowych publikacji ukazujących się na łamach „IKC” w rocznice bitwy z 1920 r. Na jej podstawie można stwierdzić, że redakcja dziennika przez wiele lat nie brała znaczącego udziału w kształtowaniu i upowszechnianiu w świadomości społecznej mitu „Cudu nad Wisłą”. Wydarzenie to traktowano głównie jako fakt historyczny a nie nadprzyrodzoną interwencję.
Binding Waste as Evidence for the Reconstruction of a Lost Aristotelian Manuscript
Authors: Beullens Pieter
Published: January 2024

This note discusses the hypothetically reconstructed content of a fourteenth-century Latin manuscript of Aristotle's Parva naturalia, from which two bifolia survive as flyleaves in an incunable binding. The note argues that the lost manuscript contained a collection of Aristotelian treatises in combination with short texts by Avicenna and Thomas Aquinas, which had a limited circulation in German-speaking regions.
Factors Affecting Waiting Time for Outpatient Prescription Services at Pukesmas Betoambari Baubau City
Authors: Endriana Eky
Published: January 2024

Background: Factors that can affect the waiting time are the number of prescriptions and the completeness of the prescription, the availability of human resources, the availability of drugs in accordance with the prescription, the standard operating procedures used.

Objectives: The aims of this research is to determine the factors that influence the waiting time for outpatient prescription services at the Betoambari Health Center, Baubau City.

Research Metodes: The research method used is analytic observational with a cross sectional study approach. The population of this study were all outpatients at the Betoambari Health Center. The number of samples is 358 respondents. The sampling technique used is Simple Random Sampling. The data analysis used was Univariate, Bivariate, and Multivariate Analysis.

Results: The results of this study indicate that there is no effect of the number of prescriptions and prescription completeness with waiting time for prescription services (p value = 0.602 > = 0.25), there is an effect of availability of human resources with waiting time for prescription services (p value = 0.001 < = 0.25), and there is an effect of drug availability with waiting time for prescription services (p value = 0.153 < = 0.25).

Conclusion: The conclusion of this study is that there is no influence between the number of prescriptions and the completeness of prescriptions, the availability of human resources, and the availability of drugs with the waiting time for prescription services.

Keywords: drug prescription, outpatient, waiting time.
Community Satisfaction Index for the Posyandu Servant Program in Dusun Vii, Sukamaju Village, Percut Sei Tuan District, Deli Serdang Regency
Authors: Aidha Zuhrina , Siahaan Mardiana Lestari , Ritonga Sri Bulan suci , Fernanda Deza , Lubis Nelly Revita , Chairani Nasya Cantik , Anwar Zhafira Kurnia , Aulia Zahara  , Anju Minta Marito  , Siti Aziza Simatupang  , Sabila Tamimi Siregar  , Yuliawati Anggraini Siregar
Published: January 2024

Posyandu merupakan salah satu bentuk Upaya Kesehatan Bersumberdaya Masyarakat (UKBM) yang perannya sangat diperlukan bagi masyarakat sebagai garda terdepan dalam memberikan pelayanan kesehatan terutama bagi ibu, bayi dan balita. Penelitian ini bertujuan untuk mengetahui indeks kepuasan masyarakat terhadap pelayanan posyandu di Dusun VII Desa Sukamaju. Metode penelitian yang digunakan adalah pendekatan kualitatif untuk meneliti indeks kepuasan responden terhadap program posyandu. Teknik pengumpulan data yang digunakan adalah teknik wawancara dan beberapa data dan dokumen terkait. Hasil dari penelitian ini menunjukkan bahwa masyarakat di Dusun VII Desa Sukamaju menunjukkan kepuasan terhadap pelayanan posyandu dikarenakan kemudahan persyaratan dalam mendapatkan pelayanan dan kemudahan dalam mendapatkan informasi terkait posyandu.

Kata Kunci: Posyandu, Indeks Kepuasan, Pelayanan Kesehatan
Relationship Patient Service to Quality of Nursing Services During COVID-19 Pandemic at Meo-Meo Health Center
Authors: Darmawan Agus
Published: January 2024

Background: Puskesmas which is spearhead in breaking of transmission COVID-19, needs to make efforts prevent and transmit infection.

Objectives: Purpose study was to determine relationship between patient care in form reliability, responsiveness, assurance, empathy, direct evidence quality nursing services during COVID-19 pandemic.

Research Metodes: Type research used is cross sectional study. Population were all outpatients who came for treatment as many as 1681 people, sample was 95 people and side method used was purposive sampling. Analysis used was univariate analysis and bivariate analysis at 95% confidence (a = 0,05).

Results: Results showed that reliability relationship had ρ=0,000<α=0,05, responsiveness relationship had ρ=0,002<α=0,05, assurance relationship had a ρ=0,007<α=0,05, empathy relationship had ρ=0,001<α=0,05, direct evidence relationship has ρ=0,000<α=0,05 to quality of nursing services during COVID-19 pandemic.

Conclusion: Conclusion shows that is a relationship between patient care and quality of nursing services during COVID-19 pandemic at Meo-Meo Health Center.

Keywords: patient care; quality of nursing service; public health center

 

Abstrak

Latar Belakang: Puskesmas yang sebagai ujung tombak dalam memutus mata rantai penularan COVID-19 perlu melakukan upaya pencegahan dan penularan infeksi.

Tujuan: Tujuan penelitian yaitu mengetahui hubungan pelayanan pasien berupa kehandalan, ketanggapan, jaminan, empati, bukti langsung terhadap mutu pelayanan keperawatan selama masa pandemi COVID-19.

Metode Penelitian: Jenis penelitian yang digunakan adalah cross sectional study. Populasi dalam penelitian ini adalah semua pasien rawat jalan yang datang berobat yaitu sebanyak 1681 orang, sampel berjumlah 95 orang dan metode samping yang digunakan adalah purposive sampling. Analisis yang digunakan adalah analisis univariat dan analisis bivariat pada taraf kepercayaan 95% (a = 0,05).

Hasil: Hasil penelitian menunjukkan bahwa hubungan kehandalan   memiliki nilai ρ=0,000<α=0,05, hubungan daya tanggap memiliki nilai ρ=0,002<α=0,05, hubungan jaminan memiliki nilai ρ=0,007<α=0,05, hubungan empati memiliki nilai ρ=0,001<α=0,05, hubungan bukti langsung memiliki nilai ρ=0,000<α=0,05 terhadap mutu pelayanan keperawatan selama masa pandemi COVID-19.

Kesimpulan: Kesimpulan menunjukkan bahwa ada hubungan pelayanan pasien terhadap mutu pelayanan keperawatan selama masa pandemi COVID-19 di Puskesmas Meo-Meo.
RELATIONSHIP OF KNOWLEDGE, ATTITUDE AND ACTION WITH PERSONAL HYGIENE OF FOOD HANDLERS AT NUTRITION INSTALLATION RADEN MATTAHER HOSPITAL JAMBI
Authors: Naibaho Magdalena
Published: January 2024

RESEARCH BACKGROUND : Personal hygiene is an effort to maintain the cleanliness of employees and food handlers through routine checks on the cleanliness of hair, teeth and mouth, nails, work clothing and work appearance. The purpose of personal hygiene is to prevent food contamination of food handlers at the Nutrition Instalation. This study was to determine the Relationship Of Knowledge, Attitude And Action With Personal Hygiene Of Food Handlers At The Nutrition Installation Of Raden Mattaher  Hospital Jambi

METHODE : This research is a quantitative research with a cross sectional research design. The population is all officers who are responsible for the Nutrition Installation at the Raden Mattaher General Hospital Jambi, totaling 35 people, and the sample is determined using a total sampling technique. Retrieval of data using questionnaires, observations and interviews. Statistical test using the chi square test.

RESULT : The results showed that knowledge was not good (20%), attitudes were not good (43.8%) and actions were not good (40.6%). The results of the bivariate analysis showed that there was an effect between knowledge and personal hygiene (P = 0.033), there was an effect between attitudes and personal hygiene (P = 0.181) and there was an effect between action and personal hygiene (P = 0.030).

RECOMMENDATION : for Nutrition Installations to increase knowledge, attitudes and actions of food handlers by counseling, personal hygiene training, and increasing supervision  performance or behavior of food handlers.
Pengaruh Pendidikan Kesehatan tentang Personal Hygiene saat Menstruasi Melalui Media Video Terhadap Pengetahuan dan Sikap pada Siswi SMP Negeri 29 Samarinda
Authors: Chandra Mey Reta , Hazanah Sri , Dian Ardyanti
Published: January 2024

Abstrak

Latar Belakang: Kebersihan diri adalah pemeliharaan kesehatan dan kesejahteraan individu dalam menjalankan kehidupan sehari-hari sehingga dapat melindungi diri dari agen penyebab gangren. Mengingat perempuan pada umumnya memiliki tingkat pengetahuan yang rendah tentang perawatan diri, maka tujuan penelitian ini adalah untuk mengkaji bagaimana perempuan diajarkan tentang perawatan diri saat menstruasi melalui penggunaan media video dalam kaitannya dengan pengetahuan dan sikap siswi di sekolah. SMP Negeri 29 Samarinda.

Tujuan: Tujuan penelitian ini adalah untuk mengetahui bagaimana perasaan pendidik kesehatan di SMP Negeri 29 terhadap pengetahuan dan sikap siswa seputar kebersihan dan keamanan menstruasi dalam kaitannya dengan media video.

Metode: Penelitian menggunakan desain one-group pretest-posttest dengan menggunakan metodologi pra-eksperimental dan pendekatan kuantitatif untuk mengumpulkan data. Metode ini melibatkan dua putaran observasi: pretest sebelum intervensi dan posttest segera setelah intervensi. Dengan demikian, hasil intervensi akan lebih akurat mencerminkan hasil pretest dan posttest.

Hasil: Berdasarkan identifikasi pengetahuan siswa sebelum dan sesudah intervensi diketahui bahwa sebagian besar responden mempunyai pengetahuan. Sekitar 15 siswi dinyatakan positif pada hari pre-test (18,1%).

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Selain itu, mayoritas responden yang mempunyai jawaban valid pada saat post-test berjumlah sekitar 76 siswi (91,6%). Terdapat bukti adanya pendidikan kesehatan kebersihan diri saat menstruasi melalui media video jika dibandingkan dengan pengetahuan dengan p-value 0,000 (p=0,05). Berdasarkan identifikasi sikap siswa sebelum dan sesudah intervensi diketahui bahwa sebagian besar responden atau sekitar 0 (0%) berada pada kategori respon sangat baik pada saat pre-test. Selain itu, diketahui bahwa mayoritas responden atau sekitar 42 siswi (50,6%) berada pada kategori respon sangat baik pada saat post-test. Terdapat bukti adanya pendidikan kesehatan kebersihan diri saat menstruasi melalui media video jika dibandingkan dengan pengetahuan dengan p-value 0,000 (p<0,05).

Kesimpulan: Siswa di SMP-29 Samarinda, Indonesia, diteliti untuk mengetahui pengaruh pendidikan kesehatan yang disampaikan melalui video terhadap pengetahuan dan sikap siswa terhadap kebersihan menstruasi. Penelitian ini diharapkan dapat menjadi bahan pemikiran dan sumber informasi yang bermanfaat bagi mahasiswi.

Kata kunci: Personal Hygiene, Pengetahuan, Sikap
Lack of Effect of Biowish Multibio 3PS Probiotic on Bacterial Cold-Water Disease-Induced Mortality in Rainbow Trout
Authors:   South Dakota Game, Fish, And Parks McNenny State Fish Hatchery, Huysman Nathan
Published: January 2024

Flavobacterium psychrophilum, the causative agent of Bacterial Cold-Water Disease (BCWD) is prevalent in salmonid hatcheries worldwide.
Theoretical Approach to Classical Chinese Medicine – Macrocosmic Dimension
Authors:   Tzu Chi University, Chen Yee-Guang
Published: January 2024

Traditional Chinese Medicine (TCM) including herbal medicine, acupuncture and moxibustion has been promoting worldwide for over seventy years.
Severe Liver Steatosis from L-Asparaginase May not Recur Following Drug Re-Challenge
Authors:   Department Of Gastroenterology, Thomas Worland
Published: January 2024

We have demonstrated that re-trial of L-asparaginase following an episode of hepatotoxicity is usually safe and may not precipitate recrudescence of hepatotoxicity; this finding may help inform future treatment with this drug.
Esophageal Plexiform Fibromyxoma: An Unusual Localization
Authors:   SC Gastroenterologia ASL 2 Savonese, Lorenzo Del Nero
Published: January 2024

PF is mostly found in the gastric antrum. However, it has been described in other GI tract segments such as duodenum, jejunum, gallbladder and mediastinum [2]. Esophageal presentation is extremely rare.
Optimistic Stratagems of Machine Based Deep Learning Employed with Automation in Psychiatry and Early Neurodevelopmental Disorders
Authors:   Department Of Biotechnology And Bioinformatics, Margret A Anita
Published: January 2024

Conversely, the contents uplift the promise of machine learning at varied levels in neuroscience investigation to discover the working of neural network and brain functioning.
Agenda for Reframing Cluster B Personality Disorders as Disrupted Separation-Individuation and Dissociative Post-traumatic Syndromes
Authors:   Former Visiting Professor Of Psychology, Vaknin Sam
Published: January 2024

Recasting cluster B personality disorders as post-traumatic conditions which involve dissociation goes a long way towards resolving these outstanding conundrums.
Commentary: Disseminated Adult Wilms Tumour in Pregnancy- Leveraging Multidisciplinary Care in a Low Resource Setting
Authors:   University Of Ghana Medical School, TK Boafor
Published: January 2024

Adult Wilms tumor is a rare occurrence with limited examples cited in literature. It is predominantly a childhood tumor occurring between the average ages of 2 to 3 years but can occur up to age 8 years and for unknown reasons it affects more African children than Caucasians [1,2].
New Record of the Egg-larval Parasitoid, Chelonus formosanus Sonan of Fall Armyworm, Spodoptera frugiperda (J.E. Smith) in the Philippines
Authors: Calcetas Orlando Adona , Joshi Ravindra Chandra , Gupta Ankita , Ranjith Avinjikkattu Parambil , Madrid Mary Ann , Fameronag Joash
Published: January 2024

The egg-larval parasitoid on fall armyworm (FAW), Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae) have not reported in the Philippines. This paper summarizes the global biological information on two species of Chelonus and their role in the regulation of FAW. The FAW egg masses and larvae were collected in the corn plantations inside the Lipa Agricultural Research Station, Marawoy, Lipa City, Batangas. The collected egg masses and larvae were reared at the Entomology Laboratory of the Department of Agriculture-Regional Crop Protection Center IVA. The larvae of FAW were observed for the emergence of parasitoids. Two cocoons of the parasitoid from the rearing cages were obtained for species determination. Three adults from the emerged parasitoids, each male and female, were initially preserved and labeled. Color images of habitus and other morphological characters of the parasitoid were taken using a DSLR camera attached to an Olympus SZ61-60 microscope. This research found two species that emerged from FAW: Chelonus formosanus and the new record of C. semihyalinus. We also highlight the need for more research in the Philippines on exploring the diversity of indigenous natural enemies, the development of mass-rearing techniques, and their utilization to manage fall armyworms.
Kajian Pemilihan Rute Angkutan Wisata dalam Mendukung Pariwisata Kabupaten Kebumen dengan Metode All or Nothing
Authors: Hidayanto Rizki , Puspitasari Evi , Firmansyah Dedy
Published: January 2024

Salah satu daerah pariwisata yang sedang berkembang di Jawa Tengah adalah Kabupaten Kebumen. Namun, ada beberapa problematika terkait pengembangan wisata tersebut, salah satunya adalah aksesibilitas. Permasalahan aksesibilitas merupakan hal pokok yang menyebabkan wisatawan kesulitan untuk mengunjungi lokasi wisata di Kabupaten Kebumen. Berdasarkan permasalahan tersebut, diperlukan kajian terhadap kebutuhan angkutan wisata, seperti halnya pemilihan rute angkutan wisata. Metode penelitian dilakukan dengan pemilihan moda secara sederhana dengan menggunakan metode pembebanan pemilihan rute All or Nothing Assignment. Berdasarkan hasil analisis Matriks Asal Tujuan (MAT), sebanyak 89,55% wisatawan di Kabupaten Kebumen bersedia untuk memilih angkutan wisata sebagai moda transportasi menuju lokasi wisata. Hal ini dikarenakan pertimbangan faktor biaya dan kenyamanan. Terdapat 3 alternatif rute angkutan wisata terpilih yang memiliki jarak tempuh lebih dekat dan optimal dari segi biaya dan waktu untuk distribusi. Rute tersebut adalah A dengan jarak tempuh 49,6 km, rute B sejauh 32,80 km, dan rute C dengan jarak 51,40 km.
Biotechnology Patent Law Top Ten of 2022: Inducement, Clear Error, and Interferences Galore
Authors: Noonan Kevin E. , Torrance Andrew W.
Published: January 2024

Five-year anniversaries are symbolized by a product of natural biotechnology: wood. This article marks the wood anniversary of the “Top Ten Biotechnology Patent Cases” series that began in 2018. Imagining the world in 2018 is challenging, in part because it was, indeed, a different world. There had not been a major pandemic in one hundred years. Inflation was low. The economy hummed along. No individual war appeared to threaten more than regional stability. O tempora, o mores! The year 2022 was quite different. SARS-CoV-2 continued to stalk the land, having had a monumentally mortiferous effect for several years. High inflation was rampant. The economy was still recovering from one of the deepest declines in history, with imbalances across many sectors. Moreover, eastern Europe had let slip the dogs of war, threatening peace worldwide.

Biotechnology also has seen changes of significant magnitude. Venture capital investment in biotechnology was small compared to what it is now. Efficient genome editing was restricted to first-generation CRISPR-Cas9 systems, while now it may be accomplished using more powerful and accurate methods, like base editing and prime editing (the latter offering hope for treatment in almost 90% of genetic diseases). Courts had declared that diagnostic methods did not constitute patentable subject matter, which remains the case today, although clever draftswomen continue their efforts to obtain claims protecting such methods to some extent.

Over the course of 2022, courts decided a generous selection of cases covering a wide variety of biotechnology patent law issues. These cases ran the gamut, from patent doctrines concerning satisfaction of the written description requirement for antibody claims to mechanisms for augmenting patent terms using either Patent Term Extension, or Patent Term Adjustment, or both. This article has chosen ten of the most important, though, as is the case every year, our choice of only ten was difficult, and, by necessity, left worthy cases on the cutting room floor.
Pengomposan Tandan Kosong Kelapa Sawit yang Ditambahkan Berbagai Jenis Kotoran Hewan Ternak dan Penentuan Kualitas Kimia Bokashi Berbasis Standar Nasional Indonesia
Authors: Yunda Alifia Dearta , Saputra Riza Adrianoor , Sari Nukhak Nufita
Published: January 2024

Oil palm empty fruit bunch (OPEFB) is a large amount of palm oil industry waste and has the potential to be used as bokashi fertilizer with the addition of livestock manure to enrich its nutrient content. This study aims to determine the chemical quality of OPEFB bokashi by adding each chicken, cow, and goat manure based on the quality standards of organic fertilizer INS-19-7030-2004. The research was conducted from June to August 2022 in Tanah Bumbu Regency, South Kalimantan, and the Soil Laboratory of the Department of Soils, Faculty of Agriculture, Lambung Mangkurat University, Banjarbaru, South Kalimantan. This study used a quantitative method (nutrient analysis in the laboratory). The following treatments were used: K0 = OPEFB without adding livestock manure, K1 = OPEFB with adding chicken manure, K2 = OPEFB with adding cow manure, and K3 = OPEFB with the addition of goat manure. The results showed that treatment K1 (bokashi OPEFB with chicken manure) had better chemical quality than treatments K0, K2, and K3, namely parameters organic C (13,72%), total N (0.92%), C/N ratio (14.91%), total P (1.00%), total K (0.60%), total Ca (6.56%), and total Fe (0.02%). However, the total Mg parameter in the K1 treatment was 1.36% above the maximum SNI limit, and the pH parameters in all treatments (K0 4.91, K1 5.89, K2 4.59, and K3 5.05) were not in accordance with SNI-19-7030-2004.
Perfil de internamentos obstétricos no Amapá pela Covid-19
Authors: Batista Késsia Regina Ferreira , Andrade Rosemary Ferreira de , Pureza Demilto Yamaguchi da , Cárdenas Anneli Mercedes , Mata Nely  Dayse Santos da
Published: January 2024

Objetivo: Identificar as características clínicas e epidemiológicas de gestantes diagnosticadas com covid-19, em um município do estado do Amapá.  Métodos: Trata-se de um estudo descritivo retrospectivo. A amostra foi composta por 18 gestantes com covid-19, atendidas no Hospital Universitário do Amapá, entre junho e dezembro de 2020. A coleta de dados foi realizada em prontuários, analisando as variáveis sociodemográficas, sinais e sintomas da covid-19, tipo de parto, internação em Unidade de Terapia Intensiva e desfecho materno e neonatal. Resultados: A idade média das gestantes foi de 25,2 anos, a maioria era parda, com ensino médio completo e dona de casa. As comorbidades mais evidenciadas foram hipertensão arterial sistêmica e obesidade. As complicações maternas mais observadas foram a pré-eclâmpsia e eclâmpsia, e quase metade das gestantes necessitaram de Unidade de Terapia Intensiva (UTI). Foram registrados três óbitos maternos. Conclusão: Gestantes com comorbidades, no terceiro trimestre de gestação, apresentaram desconforto respiratório com necessidade de cuidados intensivos e desfechos desfavoráveis.
Fatores preditores do bom e mau controle glicêmico dos pacientes com diabetes mellitus tipo 2 acompanhados em um serviço especializado no Rio de Janeiro
Authors: Moça Alice Bravim Fernandes , Girotto Renan , Perozo Andrea Faria Dutra Fragoso , Marques Thamyres , Queiroz Lucas Lobo de , Pagung Lucas Sarter
Published: January 2024

Objetivo: Avaliar fatores sociodemográficos, de adesão e clínico-laboratoriais como potenciais preditores de bom e mau controle glicêmico em pacientes com diagnóstico de Diabetes Mellitus tipo 2 (DM2). Métodos: Foi realizado um estudo observacional e retrospectivo com 100 pacientes em um centro de referência de tratamento de diabetes no Rio de Janeiro, que se propôs a identificar fatores preditores do bom e mau controle glicêmico em pacientes diabéticos tipo 2, durante o período de 2018 a 2020. Foram correlacionadas variáveis sociodemográficas, de saúde e tratamento com os níveis de hemoglobina glicada (HbA1c), estratificados em QUARTIS e divididos em muito bom, bom, ruim e muito ruim. Resultados: Na amostra houve predomínio do controle glicêmico ruim (33%) e observou-se que sexo (p=0,013), idade ao diagnóstico do diabetes (p=0,016), adesão à automonitorização glicêmica (p=0,002) e acompanhamento anual com oftalmologista (p=0,036) foram as variáveis que se apresentaram como preditoras para os níveis de hemoglobina glicada. Conclusão: A investigação de preditores do bom controle glicêmico é importante visto a alta prevalência da Diabetes e suas complicações, e serve como base para realizar intervenções mais efetivas no tratamento.
Complication rates in phacoemulsification surgeries performed by trainee residents
Authors: Wairagade Nikhilesh Anil , Devasia Jeason , Deshmukh Mona , Surana Shruti Dharamraj
Published: January 2024

Objectives:

Phacoemulsification with a foldable intraocular lens is the gold standard of cataract treatment. Studies have shown that various risk factors affect the visual outcome of cataract surgery. One of these is the availability of well-trained surgeons. Here, we are trying to understand how to achieve good surgical outcomes even if the surgeon has low surgical experience.

Materials and Methods:

A hospital-based prospective study was done from August 2019 to March 2021. After a detailed examination, each patient was scored based on the risk factors associated and classified into various risk groups. A total of 286 patients were studied, out of which consultants operated on 143 patients and 143 patients were operated on by trainee residents. The intraoperative and postoperative complication rates are compared based on the complexity of cases between trainee residents and consultants.

Results:

About 82.5% of the patients operated by trainee residents and 78.32% of patients operated by consultants belonged to the no-risk group with complication rates of 2.50% and 1.80%, respectively, which was statistically not significant. In the case of patients with associated preoperative risk factors, 36% of patients operated on by trainee residents had complications, and 9.6% of patients operated on by consultants had statistically significant complications.

Conclusion:

Preoperative stratification and allocation of cases according to associated risk factors help reduce complications, help trainee residents gain essential surgical skills, and give better surgical outcomes for patients.
Association between Vitamin A and cancer: A review
Authors: Vani B. S. Niranjanaa , Supriya V.
Published: January 2024

Vitamin A is a fat-soluble micronutrient vital for the immune system, cellular differentiation, epithelial barrier function, and eyesight; they also play a significant function as a potent antioxidant regulating oxidative stress and the onset of cancer. There are two ways to get it through food: Provitamin A (beta-carotenoid) and preformed Vitamin A (retinol and retinyl ester). Uncontrolled cell proliferation and the development of metastatic features are characteristics of cancer initiated by agents such as aflatoxin, tobacco smoke’s carcinogenic compounds, and solar ultraviolet radiation. Vitamin A, an antioxidant vitamin, is hypothesized to exert chemo-preventive effects and reduce the risk of cancer by preventing tissue damage through the capture of organic free radicals, an end-product of numerous metabolic processes. This review is performed to investigate the association between Vitamin A and cancer. From March 2017 to March 2022, relevant articles were searched through PubMed, Science Direct, and Google Scholar databases. All the studies involving Vitamin A and cancer were included in this review. Intake of Vitamin A was significantly inversely associated with improved cancer prognosis. The present review demonstrates that there is an inverse association between Vitamin A and cancer treatment.
An anthropometric assessment method for facial profile determination in forensics
Authors: Sreevalli Uppuganti Devi Naga , Buddha Harika Varshita , Uppala Divya
Published: January 2024

Objectives:

It is extremely difficult for forensic experts to identify the individuals, especially during mass disasters and natural calamities such as earthquakes. In most cases, the facial profile is completely destroyed and the dentition is the only source or tool which helps in identifying the individuals and their gender. The aim of this study was to evaluate and correlate inner intercanthal distance (IICD), outer intercanthal distance (OICD), interalar distance (IAD), and bizygomatic width (BZW) to the maxillary intercanine distance (MICD) to determine facial profile and gender.

Material and Methods:

The study was carried out after informed consent and involved 100 subjects who satisfied the inclusion criteria. Five parameters were measured: IICD, OICD, IAD, BZW, and MICD using digital Vernier caliper. The data were summarized in table form and were statistically analyzed using Pearson correlation.

Results:

OICD was more in females, whereas MICD was more in males. Significant correlation was observed between IICD and BZW (r = 0.224, P = 0.014), IICD and IAD (r = 0.411, P = 0.001), BZW and MICD (r = 0.229, P = 0.022), and IAD and MICD (r = 0.247, P = 0.013); negative correlation was observed between OICD and MICD (r = −0.023, P = 0.818).

Conclusion:

MICD can be used as a tool for the determination of facial profile and gender, although a larger sample size is required for further study.
Bimetallic ternary Cobalt Bismuth Iodide for visible-light-drive N photocatalytic degradation of industrial dyes (TB)
Authors: Sharma Suraj , Samota Jayanti , Intodia Kumud
Published: January 2024

In the water treatment process, sustainable, easy, effective and less expensive technique is always challenging and demanding. For this perspective, metal iodide shows great efficiency towards dye degradation processes. The present work explores the degradation of toluidine blue with the help of synthesized cobalt bismuth iodide (CBI). Structural and textural features show that on the sheet of bismuth iodide, tiny particles of cobalt iodide are uniformly distributed. The effect of various parameters such as – initial pH, dye concentration, amount of cobalt bismuth iodide and exposure of light intensity were examined. The experimental results indicate that cobalt bismuth iodide is having the advantage of the photodegradation process and is considered a significant new photocatalyst. The kinetics involved in the degradation was found to follow the pseudo-first-order kinetic model. At last, we discuss possible mechanisms for the mineralization of toludine blue. This study reveals a new choice for the potential application of cobalt bismuth iodide for the degradation of organic pollutants in water streams.
Hand power
Authors: Пальцын А.А. , Свиридкина Н.Б.
Published: January 2024

Человека создал труд. Он осуществляется определением мозгом ментально задачи, а затем её материальным, физическим выполнением преимущественно руками, кистями рук. Мысль материальна, она создается в результате физико-химических процессов в клетках мозга. Её материализация на бытовом уровне чаще всего выражается перевоплощением молекулярных процессов в клетках мозга в движения кистей рук. Поэтому динамические характеристики кистей рук – важный показатель когнитивного и двигательного здоровья человека.

Labor created man. Labor is produced by determining a task mentally by the brain followed by accomplishing the task physically, mostly with the hands and wrists. The thought is material; it is created by physico-chemical processes in brain cells. At the everyday level, materialization of thoughts most often occurs by the transformation of molecular processes in the brain into movements of the hands. Therefore, dynamic characteristics of the hands are an important indicator of the cognitive and motor human health.
Sperm DNA fragmentation: association with infertility and methods of correction
Authors: Громенко И.Д. , Галимова Э.Ф. , Громенко Р.И. , Галимов Ш.Н. , Громенко Д.Д. , Галимов К.Ш. , Литвицкий П.Ф.
Published: January 2024

В 2021 г. оценка масштаба фрагментации ДНК сперматозоидов вошла в руководство Всемирной Организации Здравоохранения в качестве метода диагностики мужского бесплодия. Невозможность естественного зачатия, аномальное развитие эмбрионов, рост частоты выкидышей, уменьшение частоты живорождения, снижение эффективности экстракорпорального оплодотворения, интрацитоплазматической инъекции сперматозоидов и внутриматочной инсеминации – все это связывают с высоким уровнем фрагментации ДНК сперматозоидов. К основным причинам, нарушающим целостность генетического материала гамет, относят ошибки при конденсации хроматина, незавершенный апоптоз и окислительный стресс. Среди методов преодоления бесплодия, связанного с высоким уровнем ДНК-фрагментации, выделяют: устранение модифицируемых факторов риска (курение, варикоцеле, ожирение), антиоксидантную терапию, короткий срок абстиненции, применение донорских ооцитов в программах ВРТ, а также методы селекции клеток в программах ИКСИ (ICSI – Intracytoplasmic sperm injection) и применение тестикулярных сперматозоидов, полученных при биопсии яичка.

In 2021, the assessment of sperm DNA fragmentation level was included in the World Health Organization guidelines as a diagnostic method for male infertility. The inability to conceive naturally, abnormal embryo development, increased miscarriage rates, decreased live birth rates, and decreased effectiveness of in vitro fertilization, intracytoplasmic sperm injection, and intrauterine insemination are all associated with high levels of sperm DNA fragmentation. The major causes that compromise the integrity of the genetic material of gametes include errors in chromatin condensation, incomplete apoptosis, and oxidative stress. Among the methods to overcome infertility associated with high levels of DNA fragmentation are: elimination of modifiable risk factors (smoking, varicocele, obesity), antioxidant therapy, short withdrawal period, use of donor oocytes in ART programs, as well as cell selection methods in ICSI programs and use of testicular spermatozoa obtained by testicular biopsy.
DISTRICT ROAD DATABASE MANAGEMENT BASED ON GEOGRAPHIC INFORMATION SYSTEM TO SUPPORT REGENCY ROAD MAINTENANCE (CASE STUDY: SINTANG DISTRICT)
Authors: Kurniawan Yengkie , Widodo Slamet
Published: January 2024

Road maintenance on the section of the road classified as a district road in the Sintang sub-district is the responsibility of the Sintang District Government. The financial constraints of the Sintang District Government, allocated annually in the Regional Revenue and Expenditure Budget (APBD) of Sintang District, pose a challenge in realizing the plan for district road maintenance, whereas funding for road maintenance needs to be budgeted regularly to maintain the road conditions in good shape, therefore, in this case, stakeholders or decision-makers are expected to be able to consider and decide which road sections should receive recommendations for "urgent," "immediate," and "postponed" maintenance. The chosen road maintenance points must not solely prioritize the lowest construction costs, accessibility, or strategic area value. Indeed, in this case, an analysis is required to integrate various criteria, thus serving as the basis for a decision as the best choice. The research method is presented descriptively, explaining the determination of the scale for recommending maintenance of district roads. The data collection technique is carried out using primary data in the form of documentation photos of each road section and road condition data assessed using the Road Condition Index (RCI) method or road roughness index, as well as secondary data consisting of road inventory data, road condition data, accident data, area size data, socioeconomic data, and maps. The fulfillment of the Minimum Service Standards (MSS) for roads is then calculated based on the collected data. This includes both the MSS for individual road sections and the MSS for the road network. The fulfillment of the road network's MSS is divided into three aspects: accessibility, mobility, and safety. Based on the analysis of the MSS, it is categorized into three recommendations: "urgent," "immediate," and "postponed." After obtaining the recommendations for each road section, they are presented as a map. After obtaining the research results, two road sections fall under the "urgent" recommendation for road maintenance. For immediate recommendations, there are 15 road sections. Meanwhile, 44 road sections are included in the delayed recommendations for road maintenance to be carried out.
Multicomponent delivery system based on biologically produced gold nanoparticles for targeted therapy of breast cancer in vivo
Authors: Pourali Parastoo , Neuhoferova Eva , Dzmitruk Volha , Svoboda Milan , Stodulkova Eva , Flieger Miroslav , Yahyaei Behrooz , Benson Veronika
Published: January 2024

This study recognized biologically produced gold nanoparticles (AuNP) as multiple cargo carriers with a perspective of drugs delivery into specialized tumor cells in vivo. Paclitaxel (PTX), transferrin, and antimiR-135b were conjugated with AuNPs and their uptake by mouse tumor cells in an induced breast cancer model was investigated. Each of the above-mentioned molecules was conjugated to the AuNPs separately as well as simultaneously, loading efficiency of each cargo was assessed, and performance of the final product (FP) was assessed. After tumor induction in BALB/c mice, sub-IC50 doses of FP as well as control AuNPs, PTX, and PBS were administered in vivo. Round AuNPs were prepared using Fusarium oxysporum and exhibited size of 13 ± 1.3 nm and zeta potential of -35.8 ± 1.3 mV. The cytotoxicity of individual conjugates and FP were tested by MTT assay in breast tumor cells 4T1 and non-tumor fibroblasts NIH/3T3 cells. The conjugation of the individual molecules with AuNPs was confirmed and FP (size of 54 ± 14 nm and zeta potential of -31.9 ± 2.08 mV) showed higher 4T1-specific toxicity in vitro when compared to control conjugates. After in vivo application of the FP, TEM analyses proved presence of AuNPs in the tumor cells. Hematoxylin and eosin staining of the tumor tissue revealed that the FP group exhibited the highest amounts of inflammatory, necrotic, and apoptotic cells in contrast to control groups. Finally, qPCR results showed that FP could transfect and suppress miR-135b expression in vivo, confirming the tumor-targeting properties of FP. The capacity of biologically produced gold nanoparticles to conjugate with multiple decorative molecules while remaining their stability and effective intracellular uptake makes them promising alternative strategy superior to current drug carriers.
LABORATORY ANALYSIS OF SOIL PHYSICOCHEMICAL PROPERTIES BASED ON AGRICULTURAL FERTILIZER INPUT REQUIREMENT APPLICATION: A CASE OF HARAMAYA UNIVERSITY, ETHIOPIA
Authors: Turyasingura Benson , chavula Petros , Mohammed Yasin , Abdi Ali Eliyas , Girma Tesfasilassie , Sadeso Kumale , Shentema Solomon , Abebe Aschalew , Katel Shambhu , Timsina Sandipa
Published: January 2024

This study aimed at assessing the soil with detail information about soil properties that are basic for agricultural input requirements such as fertilizer application. It was guided by the specific objectives which include identifying the different steps taken to undertake soil physical, chemical properties and providing basic data on the physical and chemical properties of the selected soil sampling site at Haramaya University, Ethiopia. The laboratory analysis aimed at finding out the physical and chemical soil properties on the deliberate selected area indicated sand-loamy, clayey and sand. The profiles shows some variations in the patterns of the horizons within a profile. Among the soil chemical characteristics, it was found that the soil pH in soil-water suspension varied from 7.63-7.65. Electro-conductivity was very low varying from 0.08 to 1.00 ds/m with an average value of 0.54 ds/m. The maximum exchangeable sodium percentage (ESP) value calculated is 6.36 % where the minimum is 0.36 % and averaged value of 3.36 %. Cation Exchange Capacity ranged from 13.20 to 40.38cmol (+)/kg of soil, with mean value of 27.94 cmol (+)/kg. Exchangeable calcium ranged 4.99 cmol (+)/kg to 18.34 cmol (+)/kg with a mean of 12.02 cmol (+)/kg which is rated as high. The potassium value of (0.05, 0.82 meq/100gm), 0.06 meq/100gm and (0.13, 0.46 meq/100gm) of soil respectively. The value of the measured exchangeable sodium ranged from 0.12 to 1.22 meq/100g of soil, with a mean value of 0.44 meq/100g of soil indicating medium sodium content of the soil. Total nitrogen ranging from 0.11 to 0.37 percent which decreases from top to sub soil. In conclusion soil and agronomic management are correlated with the well being of soil. Therefore, it is recommended that integrated nutrient management activities should be adopted in the study area for optimum and sustainable production of major crops.