bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Photoluminescence Properties of Alkylbromoporphyrin
Authors: Akbar Ari Yustisia , Gusman Tania Avianda
Published: December 2022

The usage of porphyrin as a light-harvesting chromophore is considered as one of the keys to obtaining low-cost and high-efficiency dye-sensitized solar cell (DSSC). In this paper, a novel porphyrin, 5,10,15-tris(nitrophenyl)-20-(p-(11-bromo)dodecoxyphenyl))porphyrin, having a long alkyl chain and three nitro groups was synthesized. The nitro groups serve as anchoring groups to TiO2 surfaces and long alkyl chain prevents unwanted dye aggregation. The porphyrin was synthesized by condensation of p-(12-Bromododecoxy)benzaldehyde and pyrrole in propionic acid according to an adaptation of the general Rothemund method [1]. p-(12-Bromododecoxy)benzaldehyde was synthesized by nucleophilic substitution reaction between 4-hydroxybenzaldehyde and 1,12-dibromododecane in acetone. The reaction products were analyzed by 1H-NMR and mass spectroscopy. The absorption and fluorescence spectra of the porphyrin were also recorded. As results, the absorption spectrum of the porphyrin consists of a strong Soret and four weak Q-band. Compared to 5,10,15-tris(nitrophenyl)-20-(p-(11-bromo)dodecoxyphenyl))porphyrin spectrum, there is no wavelength shifting because of the incorporation of the alkyl chain. The fluorescence spectrum of the porphyrin shows two characteristic emission bands and the intensity ratio of those emission bands is always constant when irradiated by different excitation wavelength related to Soret and Q-band.
Combination of Corn Waste and Egg Shell as Zn Metal Adsorbent with Batch System
Authors: Hasanah Ulfa Imroathul , Utami Budi , Susilowati Endang
Published: December 2022

This study aims to determine: the ability of corn cobs and eggshells as Zn metal adsorbents, functional groups of corn cobs and eggshells adsorbent, what isotherm patterns occur in the adsorbent corn cobs and eggshells in adsorbing Zn metal, the optimum ratio and optimum mass of the adsorbent composition of corn cobs and eggshells in Zn metal adsorption, the optimum contact time for adsorbent corn cobs and eggshell in adsorbing Zn metal, the optimum concentration of adsorbate to be adsorbed by corn cobs and eggshell adsorbents. This study used an experimental method in the laboratory.  characterization includes functional groups using FTIR, and test the effectiveness of adsorbents using the AAS instrument. Kinetic analysis of adsorbent by adsorption isotherm with Langmuir isotherm, Freundlich isotherm, Temkin isotherm, and dubinin-radushkevivh isotherm. The results showed that: Corn cobs and eggshells can be used as zinc metal adsorbents; in the corn cobs adsorbent, there is a functional group -OH at wave number 3415,15 cm-1 and in the eggshell, there is a bent vibration of calcium carbonate at wave number 3400,65 cm-1, the adsorption process of Zn metal by adsorbent corn cobs and egg shells follows the Langmuir isotherm pattern (chemical adsorption), the comparison of the optimum composition and mass of the adsorbent corn cobs and eggshells in Zn metal adsorption are 1:2 and 0,15 grams with Zn metal adsorbed by 80,4571%,  the optimum contact time for the adsorbent corn cobs and eggshells in adsorbing Zn metal is 90 minutes with the percentage of absorbed Zn metal concentration is 75,5957%, and the optimum concentration of adsorbate for adsorbed by corn cob and eggshell adsorbents is 1 mg/L with adsorbed Zn percentage of 82,8377%.
Collaborative Governance in Natural Disaster Mitigation in Bekasi Regency, Indonesia
Authors: Noer Khaerul Umam , Putra Sipin
Published: December 2022

This article examines the role of collaborative governance in natural disaster mitigation in Bekasi Regency, focusing on three sectors: the Regional Disaster Management Agency, the village government apparatus, and the community. This study will examine each party's involvement in mitigating natural disasters in particular. This study discovered a significant number of key findings by employing an ethnographic method and analysis with the Ansel and Gash model. First, there is an imbalance between stakeholders, with the community lacking in disaster mitigation training and awareness. Second, in terms of facilitative leadership, the role of district government and community leaders as mediators is not yet broad enough to promote collaborative events in disaster management, and the community is unaware of its involvement in this collaborative endeavor. Third, on the institutional level, there is no memorandum of understanding amongst the stakeholders involved that describes this collaborative program in further detail. Furthermore, there is little transparency in the program because the community has been excluded a wide range of opportunities to participate. Fourth, there are five indications in the collaborative process as a core dimension in collaborative governance: face-to-face interaction, trust between stakeholders, forging common commitments, harmonizing perspectives, and preliminary results of collaborative effort. In this situation, the forum is not organized on a regular basis, but just at particular times, resulting in less successful and ideal collaborative disaster management outcomes.
AVANT-GARDE FORMS IN ARCHITECTURAL CONSERVATION AND STEWART BRAND’S THEORY OF CHANGE
Authors:   Faculty of Architecture and Design, University of Arts in Poznan, Poland, Bardzinska-Bonenberg Teresa , Bonenberg Agata ,   Faculty of Architecture, Poznan University of Technology, Poznan, Poland, Wagner Tomasz ,   Faculty of Architecture, Silesian University of Technology, Gliwice, Poland
Published: December 2022

The subject of the research focused on contemporary architectural forms applied in the conservation of monuments. Based on Theory of Changes and Layered Construction of an Architectural Object by Stewart Brand, diversified enterprises were examined proving that they follow the concept of differentiating life spans of the individual buildings’ layers. The research methods include analysis of the 20th c. conservation development, analysis of Brand's concept in the light of conservation assumptions, case studies and summary.
MINIMIZATION OF THE ECOLOGICAL FOOTPRINT THROUGH THE USE OF THE BUBBLES MECHANISM IN THE ARCHITECTURE DESIGN PROCESS
Authors:   West Pomeranian University of Technology in Szczecin, Poland Faculty of Architecture, Department of Housing and Technical and Ecological Basics of Architecture, Gradziński Piotr
Published: December 2022

The article concerns the problem of climate change and the need to adapt to the design process the architecture of the bubble mechanism currently operating in the sectors of enterprises and production plants, which consists in determining the maximum level of pollutant emissions. The problem is considered in the category of analysis and selection of building materials. The aim of the analyzes was determined due to the changing climate and the possibility of controlling pollutant emissions by operating in a limited area, in a kind of "bubble", with the imposition of limits the architecture. This leads to the changes in the paradigm of architectural design and the application of appropriate solutions, e.g. materials as well as technical-technological ones, controlling and minimizing the negative impact on the natural environment.
KRZYSZTOF PENDERECKI ARBORETUM IN LUSŁAWICE – A SYNERGY OF CULTURAL HERITAGE AND EXCEPTIONAL VALUES OF NATURAL DIVERSITY
Authors:   Cracow University of Technology, Poland Faculty of Architecture Chair of Landscape Architecture, Bobek Wojciech
Published: December 2022

Penderecki's Arboretum in Lusławice is an example of the creative and unique work of an outstanding composer, visionary and lover of trees. Based on the historic park was created, a new, outstanding work, a collection combining a huge number of taxa into elements of garden composition, based on significant achievements of garden art of classical culture. The high natural and cultural values seamlessly blend with the historical park and the surroundings of the Lusławice Manor. The property is a rare example today of creative development of the historic layout with new elements, without simultaneous destruction of the existing values, but rather their protection and flourishing, creating new values on a regional, national and, because of the creator himself, global scale.
PENGARUH KEPEMIMPINAN HUMAN RESOURCES MANAGER TERHADAP KEDISIPLINAN KARYAWAN DI HOTEL ROYAL DENAI BUKITTINGGI
Authors: Waryono  , Putra Syahrial
Published: December 2022

Abstrak

Penelitian bertujuan untuk mengetahui pengaruh kepemimpinan Human Resources Manager terhadap kedisiplinan karyawan di Hotel Royal Denai. Jenis penelitian digolongkan kepada penelitian deskriptif kuantitatif  dengan metode asosiatif kausal. Populasi dalam penelitian ini adalah seluruh karyawan operasional yang bekerja di Hotel Royal Denai sebanyak 49 orang dengan menggunakan teknik pengambilan sampel secara jenuh. Teknik pengumpulan data menggunakan kuesioner (angket) dengan skala likert yang telah teruji validitas dan reliabilitasnya. Data dianalisis melalui analisis deskripsi dan uji regresi linier sederhana serta nilai koefisien determinasi dengan bantuan Program Komputer SPSS versi 16.00. Hasil penelitian menunjukan bahwa: Kepemimpinan Human Resources Manager dengan kategori Baik memiliki persentase 77,38% dan Kedisiplinan karyawan dengan kategori Baik memiliki persentase 79.59%. Selanjutnya diperoleh nilai R Square sebesar 0,47 dengan taraf sig. 0,034 < 0,05, maka variabel Kepemimpinan Human Resources Manager dapat menjelaskan variabel Kedisiplinan Karyawan sebesar 47% dan 53% dipengaruhi oleh faktor lain.

Kata Kunci: Human Resources Manager, Kedisiplinan, Karyawan

Abstract

The study aims to determine the influence of the leadership of the Human Resources Manager on employee discipline at Hotel Royal Denai. This type of research is classified into quantitative descriptive research with causative associative methods. The population in this study were all operational employees who worked at the Hotel Royal Denai as many as 49 people using saturated sampling techniques. Data collection techniques using a questionnaire (questionnaire) with a Likert scale that has been tested for validity and reliability too coeficient determinan value. Data were analyzed through description analysis and simple linear regression test with the help of SPSS Computer Program version 16.00. The results showed that: Human Resources Manager leadership with the Good category had a percentage of 77.38% and the discipline of employees with the Good category had a percentage of 79.59%. Furthermore, the R Square value is 0.47 with the level of sig. 0.034 <0.05, the Human Resources Manager Leadership variable can explain the Employee Discipline variables by 47% and 53% influenced by other factors.

Keywords: Human Resources Manager, Discipline, Employees
TRADISI DAN MAKNA FILOSOFIS KULINER MINANGKABAU
Authors: Waryono  , Syarif Wirnelis
Published: December 2022

The purpose of writing this article is to describe the traditions and philosophical meanings of Minangkabau culinary. The hope is that it will be useful as a reference for the younger generation of Minangkabau in choosing traditional foods to be served at traditional ceremonies and religious rituals. Library research was chosen as a method to achieve the goal by studying books, articles and websites related to Minangkabau culinary culture. The collected data was then analyzed using interactive analysis consisting of data collection, data presentation, data reduction and drawing conclusions. Minangkabau has a tradition of malamang and maantaan pabukoan which is still ongoing today. There are several routine ceremonial traditions that are always accompanied by various traditional culinary delights, such as lamang, nasi kunyik, nasi lamak, rendang, sambareh, pinyaram, lapek bugih, galamai. The meaning contained in the food served philosophically describes the existence of traditional leaders in Minangkabau, according to the deliberation and consensus of the previous ancestors, the bond of friendship and teaching sharing, patience, halal, thoroughness, a reflection of obedience and love.
Ahkâm Defterlerine Göre Bosna'dan Merkeze Yansıyan Toprak Anlaşmazlıkları ve Çözüm Arayışları
Authors: BAYRAMOĞLU Ömer
Published: December 2022

Adaletin sağlanması insanların şikâyetlerini doğrudan veya dolaylı olarak bir kuruma sunabilmesiyle mümkün olmuştur. Bu amaçla Osmanlı taşrasında adaletin ilk basamağını oluşturan kadı mahkemeleri kurulmuş ve bu mahkemeler yargı fonksiyonunu yerine getirmişlerdir. Din ve millet ayrımı yapılmaksızın Osmanlı’da haksızlığa uğrayan herkes, bu kurumlar aracılığıyla haklarını elde etmişlerdir. Yerelde haklarını elde edemeyenler ise adaletin son başvuru mercii olan Divân-ı Hümâyun’a müracaat etmişlerdir. Divân-ı Hümâyun doğrudan padişaha bağlı bir kurum olarak çalışmış ve gelen şikâyetler padişah adına görüşülüp karara bağlanmıştır. Divân-ı Hümâyun’da görüşülen şikâyet konuları ilk zamanlarda Mühimme Defterlerine kaydedilirken 1649’dan itibaren Şikâyet Defterlerine, şikâyetlerin artmasıyla birlikte 1742 yılından itibaren Eyalet Ahkâm Defterlerine kaydedilmiştir. Çalışmanın konusu Bosna ve Bosna’ya bağlı çeşitli yerleşim birimlerinden Divân-ı Hümâyun’a akseden şikâyetlerin kaydedildiği Bosna Ahkâm Defterleridir. Söz konusu defterlere 1742-1825 tarihleri arasında kaydedilmiş hükümlerin ışığında, Bosna ve çevresinde timar sisteminin işleyişine dair bilgiler elde edilmeye çalışılmıştır. Ayrıca Ahkâm Defterlerinde; yönetici-yönetilen ilişkisi ve tarafların birbirlerine karşı yükümlülükleri, toprak ve toprağa bağlı vergiler, timar topraklarından göçler, problemler ve bu problemler için verilen hükümler incelenmiştir. İlgili hükümler çalışmanın içerisinde verilen örnekler dâhilinde kullanılarak yorumlanmıştır.
Musculoskeletal Components of Post-Acute Sequelae of SARS-CoV-2 Infections
Authors: Gagnier Joel J. , Bergmans Rachel S. , Clauw Daniel J.
Published: December 2022

» Musculoskeletal (MSK) sequelae of severe acute respiratory syndrome coronavirus 2 infections seem to be common.

» Mechanisms of such effects are becoming clear.

» There is a complex interplay of biopsychosocial effects associated with MSK symptoms after acute coronavirus disease 2019.

» Additional research should focus on completely describing the breadth of these MSK sequelae and related psychosocial symptoms.
Improving the Performance of Educators with the Effectiveness Level of Additional Employee Income (TPP) in Junior High Schools
Authors: Suciati Detik , Rodiyah Isnaini
Published: December 2022

This study aims to describe and analyze the effectiveness of Additional Employee Income (TPP) in improving the performance of educators at the State Junior High School 2 Wonoayu, Sidoarjo Regency. To analyze the supporting factors and inhibiting factors of Additional Employee Income (TPP) in improving the performance of educators at the State Junior High School 2 Wonoayu, Sidoarjo Regency. The method that the author uses in this research is a quantitative descriptive method. The sample in this study were 46 educators. Validity test using Product Moment correlation from Pearson. The results of this study indicate that the effectiveness of the additional employee income program (TPP) in improving the performance of educators at the State Junior High School 2 Wonoayu Sidoarjo, is in the effective category, because based on the overall calculation of the indicators the questionnaire distributed contains 23 (twenty three) statements with the position of the number of Effectiveness of the additional employee income program (TPP) is 4987 which is in the interval >Q2 to Q3 with a value of >2645 – 5290 which is categorized as effective.Keywords: Effectiveness, Additional Employee Income (TPP), Performance Improvement
Performance Improvement Through Servant Leadership Organizational Support and Communication on Employee Performance
Authors: Apriyanti Efa , Abadiyah Rifdah
Published: December 2022

The purpose of this study was to determine the effect of servant leadership, organizational support and communication on employee performance at PT Harapan Sejahtera Karya Utama Sidoarjo. The approach used in this research is a quantitative approach. The population in this study were 200 employees. The sampling technique used is a simple random sampling technique used for this research is purposive sampling. The sample in this study were 133 respondents. Analysis using SPSS software. The results obtained from the influence of servant leadership, organizational support and communication have a significant effect on employee performance. Servant leadership has a significant effect on employee performance, organizational support has a significant effect on employee performance and communication has a significant effect on employee performance.
Decline of young-of-year walleye (Sander vitreus) growth due to Bythotrephes impacts predicted from bioenergetic principles
Authors: Gartshore Danni J , Rennie Michael D.
Published: December 2022

Invasive species are a major threat to ecosystem structure and function. For example, Bythotrephes cederströmii (Bythotrephes hereafter) invasions have significantly reduced native zooplankton density and biomass, resulting in competitive interactions with zooplanktivorous fishes. Young of year (YOY) walleye (Sander vitreus) are initially zooplanktivorous and have recently been shown to display reduced growth in Bythotrephes invaded lakes. Here, we combined a bioenergetics model for larval walleye with changes in the zooplankton community following Bythotrephes invasion and predicted reduced larval walleye growth in the presence of Bythotrephes, supporting field observations. The model predicted greater impacts in oligotrophic versus mesotrophic lakes, whereby Bythotrephes invasion could potentially lead to walleye recruitment failure in low nutrient environments. As YOY growth, survival, and recruitment are ultimately linked to adult abundance and sustainability of managed stocks, our results highlight the potential impacts of Bythotrephes on the sustainability of walleye populations in boreal lakes.
Hurricane events facilitate the establishment of nonnative invertebrate species in harbors
Authors: Hutchings Brenna , Stiles Emma , Lopez-Legentil Susanna
Published: December 2022

The coastal location and shallow depths of harbors suggest that fouling communities will be greatly affected by extreme weather events. Within fouling communities, ascidians are conspicuous animals and their sessile nature makes them ideal targets to assess community resilience. We established ascidian diversity and abundance at eighteen harbors and marinas along the coast of North Carolina (United States) a year after Hurricane Florence landfall in 2018 (post-hurricane) and compared results with those obtained in 2014 (pre-hurricane). The distribution and community structure of native and introduced ascidians were analyzed using presence-absence and relative abundance similarity matrices. Both geographic location (North vs. South) and distance between harbors had a significant effect on ascidian community composition. When compared with pre-hurricane data, a decrease in the number of native species and an increase of introduced and cryptogenic species was noted, although these trends were only statistically significant for the number of introduced species based on presence-absence data. Monthly photo transects spanning pre- and post-hurricane periods to monitor the ascidian community at the harbor located where the hurricane made landfall, revealed that all but one species disappeared from the docks after the hurricane. Recolonization occurred slowly, and one year later, only two non-native species were present. Further, we report the arrival of the globally introduced species Styela canopus and Distaplia listerianum in North Carolina. This study significantly advances our understanding of the impact of hurricanes on fouling communities inhabiting harbors and the speed of natural recovery.
The lowest point of fibula (LPF) could be used as a reliable bony landmark for arthroscopic anchor placement of lateral ankle ligaments ----compared with open Broström procedure
Authors: Xie Xin , Chen Linxin , Fan Cunshuai , Song Shouyi , Yin Yu , Pi Yanbin
Published: December 2022

Background

Arthroscopic technique procedures was wide accepted for the treatment of chronic ankle instability (CAI). But little acknowledge was involved to the bony landmarks and anatomic features of different bundles of lateral ligaments under arthroscopic view.

Methods

Sixty patients with acute or chronic lateral ankle ligaments injury (LAI) were collected prospectively, and divided randomly into two groups. In arthroscopic group, the bone tunnels were made on the LPF arthroscopically. And in open group, the bone tunnels were made on the Fibular obscure tubercle (FOT) in open procedure. The inferior bundle of ATFL and Arcuate fibre was also identified reference to the LPF and labeled by a PDS II suture penetration. Following that, The distances of the bone tunnels to the different bony markers were measured and compare between two groups. The penetrating locations of PDS II on the inferior bundle of ATFL and Arcuate fibre were also confirmed intraoperatively. And the safe angle of anchor implantation on the axial view was measured on postoperative CT scan.

Results

The distances of bone tunnel to the fibular tip, the fibular insertion of anterior-inferior tibiofibular ligament (AITFL), and the FOT in arthroscopic and open locating groups were 4.9 ± 2.2 and 6.3 ± 2.2mm, 13.5 ± 2.7 and 12.4 ± 1.1mm, 5.8 ± 2.2 and 5.6 ± 1.0mm, respectively. The distances of bone tunnels to the FOT and fibular tip on 3d-CT view was 4.4 ± 1.5 and 4.6 ± 0.9 mm, 14.4 ± 3.2 and 13.2 ± 1.8 mm in arthroscopic and open group, and there were no significant differences between two groups. The safe angle of arthroscopic anchor placement on the axial plan was ranged from 24.9 ± 6.3o to 58.1 ± 8.0o. The PDS II sutures penetrating on the inferior bundles of ATFL and the arciform fibres were also comfirmed successfully by open visualizaion.The average distance of penetration point to the horizontal line cross the fibular tip was 2.3 ± 2.7 mm (ranged from − 3.1 to 6.0 mm), and to the vertical line cross the FOT was 2.7 ± 2.7 mm (ranged from − 2.5 to 7.5 mm).

Conclusion

Take the lowest point of fibula under arthroscopy (LPF) as a bony reference, we could identify the iATFL under arthroscopic visualization. By this way, we could place the suture anchors properly to the fibular footprint and suture the iATFL fibres successfully.
Level of Evidence: IV, Prospective comparative investigation.
A scoping review on two-stage randomized preference trial in mental health
Authors: Chen Sheng , Wang Wei
Published: December 2022

Background: Randomized Controlled Trial is the most rigorous study design to test the efficacy and effectiveness of an intervention. Patient preference may negatively affect patient performance and decrease the generalizability of a trial to clinical population. Patient preference trial have particular implications in mental health since mental health interventions are generally complex, blinding of intervention is often difficult or impossible, patients may have strong preference, and outcome measures are often subjective patient self-report which may be greatly influenced if patient’s preference did not match with the intervention received.
Methods: In this review, we have surveyed the application of two-stage randomized preference trial with focus on studies in the field of mental health. The study selection followed guideline provided by Preferred Reporting Items for Systematic Reviews and Meta-Analysis.
Results: Six two-stage randomized preference trials (ten publications) have been identified in the mental health field. In these trials, the pooled dropout rates were 18.3% for the preference arm, and 28.7% for the random arm, with a pooled RR of 0.70 (95% CI, 0.56-0.88; P=0.010) indicating significantly lower risk of dropout in the preference arm. The standardized preference effects varied widely from 0.07 to 0.57, and could be as large as the treatment effect in some of the trials.
Conclusion: This scoping review has shown that two-stage randomized preference trials are not as popular as expected in mental health research. The results indicated that two-stage randomized preference trials in mental health would be beneficial in retaining patients to expand the generalizability of the trial.
Effect of probiotic supplementation on in-hospital mortality in patients with acute myocardial infarction: a study protocol for an open-label, randomized, controlled, superiority clinical trial
Authors: Chen Rongbing , Tan Xuerui , Chen Yequn , Wang Xin , Zhou Yan , Hong Liekai , Xiong Nianling , Zhu Jinxiu , Ye Shu
Published: December 2022

Background: Recent studies have demonstrated a correlation between intestinal flora and the severity of myocardial infarction as well as post-myocardial infarction repair. However, few studies have investigated whether probiotics reduce mortality and improve cardiovascular outcomes in patients with acute myocardial infarction. In this study, we will conduct a randomized controlled trial (RCT) to evaluate the effect of probiotics on in-hospital mortality and incidence of major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI).
Methods: This is an open-label, randomized, controlled, superiority clinical trial involving 2594 adult patients who diagnosed with acute myocardial infarction. Patients will be randomized to (1)receive bifidobacteria triple viable capsule (Bifidobacterium longum, Lactobacillus acidophilus, and Enterococcus faecalis) 840 mg, twice a day, plus standard treatment strategy during the hospital stay , for a maximum of 30 days, or (2)receive the standard treatment strategy and will not take the bifidobacterium triple live capsule. The primary outcome was in-hospital all-cause mortality. Discussion: The purpose of this clinical trial is to determine whether probiotics can reduce in-hospital mortality and improve prognosis in patients with AMI, and the results will provide evidence for probiotics as a complementary treatment for AMI.
Trial registration: Chinese Clinical Trials Registry ChiCTR2000038797. Registered on 2 October 2020.
Exploring interdependencies, vulnerabilities, gaps and bridges in care transitions of patients with complex care needs using the Functional Resonance Analysis Method
Authors: Hedqvist Ann-Therese , Praetorius Gesa , Ekstedt Mirjam
Published: December 2022

Background:
Care transitions, such as a patient’s hospital discharge, are complex processes encompassing multiple interactions and requiring coordination between stakeholders. To identify potential improvement measures in care transitions for people with complex care needs, intra- and inter-organisational everyday work needs to be properly understood, including its interdependencies, vulnerabilities and gaps. The aim of this study was to map the coordination of care across healthcare and social care organisations and describe interdependencies and system variability in care transitions.
Methods:
The study was inspired by multi-method research. Data were collected through participant observations, interviews and a document review in a region of southern Sweden. The Functional Resonance Analysis Method was used to model the discharge process and visualise and analyse coordination within and between different organisations and units.
Results:
The results show that hospital discharge is a time-sensitive process with numerous couplings and interdependencies where healthcare professionals are constrained by system design and organisational boundaries. The greatest vulnerability can be found when the patient arrives at home, as maladaptation earlier in the care chain can lead to an accumulation of issues for the municipal personnel in social care working closest to the patient. The possibilities for the personnel to adapt are limited, especially at certain times of day, pushing them to make trade-offs to ensure patient safety. To counteract variability in performance of care, flexibility and adequate resources need to be ensured, to promote the possibility to respond and adjust to uncertainties.
Conclusions:
To achieve safe and secure care transitions from hospital to home, proactive work during discharge planning needs to be facilitated by improving the timing and precision in assessment and planning of patient care. Responding to unexpected events and variations requires successful adaptation and use of allocated resources during the first few days after homecoming, and a system allowing for flexibility to promote safe and personalized care.
Negative Magnetostrictive Paper Formed by Dispersing CoFe 2 O 4 Particles in Cellulose Nanofibers
Authors: Keino Takumi , Rova Lovisa , Gallet--Pandellé Alia , Kurita Hiroki , Narita Fumio
Published: December 2022

Polymers are often combined with magnetostrictive materials to enhance their toughness. This study reports a cellulose nanofiber (CNF)-based composite paper containing dispersed CoFe2O4 particles (CNF–CoFe2O4). Besides imparting magnetization and magnetostriction, the CoFe2O4 particles increase the fracture elongation of the CNF–CoFe2O4 composite paper, although the ultimate tensile strength of the composite paper decreases with increasing CNF content. As strength and toughness are usually inversely proportional, it was inferred that the magnetostrictive CNF–CoFe2O4 composite paper has good toughness.
Adjunctive duration-doubled tDCS for the treatment of depressive patients with suicidal ideation: study protocol for a double-blind, randomized, sham-controlled trial
Authors: Chen YIMING , Lyu Dongbin , Wang Fan , Huang Qinte , Yang Weichieh , Zhang Mengke , Wei Zheyi , Shi Shuxiang , Kong Shuqi , Chen Shentse , He Shuang , Yang Vivien , Fang Yiru , Douiri Abdel , Hong Wu
Published: December 2022

Backgroud: The problem of suicide has become increasingly common in individuals with major depressive disorder (MDD). Transcranial direct current stimulation (tDCS) is an effective treatment for MDD with2 milliamperes (mA) for at least thirty minutes per day for two weeks. This study aims to investigate the efficacy of daily duration-doubled tDCS as an adjunctive intervention for rapidly reducing suicidal ideation and improving depression in MDD patients.
Methods and design: In this double-blind, randomized, sham-controlled study, 76 MDD patients with suicidal ideation are randomly assigned to either active (n=38) or sham (n=38) tDCS group. The anode and cathode are placed over the scalp areas corresponding to left and right dorsolateral prefrontal cortex (DLPFC), respectively, and each stimulation lasts for 60 minutes. The primary outcome is defined as change of Beck Scale for Suicide Ideation (BSI) after 10 sessions. The 17-item Hamilton Depression Rating Scale (HAMD-17), Wisconsin Card Sorting Test (WCST) and Stroop Color-Word Test (SCWT) are utilized to assess depressive symptoms, executive function. Blood biomarkers related to suicidal ideation are collected at baseline and after 10 sessions.
Discussion: This study suggest the adjunctive duration-doubled tDCS might be a novel method to rapidly reduce suicidal ideation and improve depressive symptom. The variation of biomarkers could be potential predictive models of suicide risk.
Trial registration: The trial protocol is registered with ClinicalTrials.gov under protocol registration number NCT05555927. Registered on September 25, 2022.
TLR-mediated aggresome-like induced structures comprise antimicrobial peptides and attenuate intracellular bacterial survival
Authors: BHATNAGAR ANUSHREE , CHOPRA UMESH , Raja Sebastian , DAS KRISHANU DEY , MAHALINGAM S , Chakravortty Dipshikha , SRINIVAS SRINIVASA
Published: December 2022

Immune cells employ diverse mechanisms for host defense against pathogens. Macrophages and dendritic cells, in response to toll-like receptor (TLR) activation, assemble aggresome-like induced structures (ALIS). Our group has previously shown that engagement of TLR4 transcriptionally upregulates p62/sequestome1, which in turn assembles ALIS along with LC3 and ubiquitin. We have demonstrated that TLR4 mediated autophagy is, in fact, selective autophagy of ALIS. We hypothesize that TLR-mediated autophagy and ALIS contribute to host-defense. Here we show that ALIS are not only assembled in macrophages upon exposure to several types of bacteria, but these structures are associated with pathogen-containing phagosomes. Importantly, we also present evidence of increased bacterial burden in cells, in which formation of ALIS is prevented with p62 specific siRNA. To gain more insight into the assembly of the constituents of ALIS, we have employed 3D super-resolution structured illumination microscopy (3D SR-SIM) and mass-spectrometric analyses. Ultra-structural analyses by 3D SR-SIM of known constituents of ALIS (namely p62, ubiquitin and LC3) reveals that ALIS are organized structures with distinct patterns of alignment. Furthermore, mass spectrometric analyses of ALIS identified, among others, several proteins of known antimicrobial properties. We have validated mass spectrometry analysis data by testing the association of some of these molecules (Bst2, IFITM2 and IFITM3) with ALIS and the phagocytosed bacteria. Thus, we surmise the enrichment of AMPs in ALIS leads to their delivery to bacteria-containing phagosomes and to restrict the bacteria in host cells. Our findings in this paper support hitherto unknown functions of ALIS in host-defense.
Identification and Validation of Lipid Metabolism-Related LncRNA Prognostic Signature for Patients with Osteosarcoma
Authors: Tang Zhifang , Feng Hanzhen , Shu Longjun , Guo Minzheng , Qi Baochuang , Pu Luqiao , Shi Hongxin , Ren Junxiao , Li Chuan
Published: December 2022

Background: Osteosarcoma(OS) is the most common primary bone malignancy in ado-lescents. The function of lipid metabolism-related lncRNAs in disease progression and prognosis of osteosarcoma remains unclear. This study aimed to explore the role of lipid metabolism-related lncRNAs in osteosarcoma development and prognosis.
Methods: Pearson correlation was used for identification of lipid metabolism-related lncRNAs, and univariate and multivariate Cox regression analyses were used to construct and validate a risk signature to predict the prognosis of OS patients. Functional analysis using Gene set enrichment analysis (GSEA) to elucidate underlying mechanisms. Analysis of potential regulatory mechanisms of lipid metabolism-related lncRNAs using ceRNA networks, and they were preliminarily verified in our tissues using immunohistochemistry (IHC).
Results: We screened two lipid metabolism-related lncRNAs (SNHG17 and LINC00837) to con-struct a risk signature and validated them in the GEO database. The results showed that this risk model was an independent prognostic factor for OS patients. GSEA analysis showed that this signature may be associated with cell proliferation and metabolism-related pathways in OS patients. Cox regression, ROC curve analysis, and a nomogram indicated that the risk model was an independent prognostic factor and it showed potent potential for survival prediction in osteosarcoma. Nomogram integrating risk model and clinical characteristics could predict the prognosis of osteosarcoma patients accurately. Immunohistochemical results showed that CSNK2A2, MIF and VDAC2 were up-regulated in tumor tissues.
Conclusions: In summary, our study demonstrates that lipid-metabolism related-lncRNA could be applied to predict the prognosis of in osteosarcoma accurately.
Enantioselective Construction of Si-Stereogenic Linear Alkenylhy-drosilanes via Copper-Catalyzed Anti-Markovnikov Hydrosilyla-tion of Alkynes
Authors: Xu Yun-He , Xu Jian-Lin , Wang Zi-Lu , Zhao Jinbo
Published: December 2022

Herein we report an unprecedented copper-catalyzed asymmetricanti-Markovnikov hydrosilylation of alkynes with dihydrosilanes for the synthesis of silicon-stereogenic alkenyl silanes in good regio- and enantioselectivities. Demonstrated by a diverse collection of substrates, the process grants access to chiral alkenylhydrosilanes with a simple Cu/(S)-Tol-BINAP catalytic system. The origin of the enantiocontrol was investigated by density functional theory (DFT) calculations, which revealed a quite complicated scenario involving multiple pairs of diastereomeric transition structures accounting for the high enantiocontrol under the seemingly simple conditions.
Compression intervention on the thigh using elastic bandage on lateral femoral pain after trochanteric fractures: a multicenter randomized controlled trial
Authors: Kawanishi Kengo , Fukuda Daisuke , Miyashita Toshinori , Kitagawa Takashi , Niwa Hiroyuki , Okuno Taisuke , Kinoshita Takashi , Tsutsumi Masahiro , Kudo Shintarou
Published: December 2022

Management of postoperative pain after trochanteric fracture that is caused by decreased gliding between tissues in the lateral thigh is not established. The aim of this study was to examine the effect of compression of the thigh using an elastic bandage on trochanteric fracture after surgery. This parallel-group, multicenter randomized controlled trial with blinded participants and outcome assessors was conducted in collaboration with the Comprehensive Rehabilitation Unit (sub-acute rehabilitation Unit) in two hospitals. Eligible volunteers (n = 34) with trochanteric fractures after surgery were randomly assigned to two groups. In the compression group, participants practiced standing and walking under compression of the thigh with an elastic bandage. The sham group was blinded to the intervention and practiced standing and walking under non-compression of the thigh with an elastic bandage. Both groups underwent a standard physical therapy program two times a day, daily. Compression of the thigh with an elastic bandage significantly improved subcutaneous tissue thickness, gliding between tissues, lateral thigh pain, hip abduction muscle strength, and knee extension muscle strength. In addition, thigh compression was found to be an effective intervention for improving gait velocity.
Clinical trial registration number:
UMIN Clinical Trial Registry: No. 000038583
Healthcare professional and manager perceptions on drivers, benefits and challenges of telemedicine: results from a cross-sectional survey in the Italian NHS.
Authors: Antonacci Grazia , Benevento Elisabetta , Bonavitacola Sveva , Cannavacciuolo Lorella , Foglia Emanuela , Fusi Giulia , Garagiola Elisabetta , Ponsiglione Cristina , Stefanini Alessandro
Published: December 2022

Background:The Covid-19 pandemic provided new challenges and opportunities for patients and healthcare providers while accelerating the trend of digital healthcare transformation. This study explores the perspectives of healthcare professionals and managers on (i) drivers to the implementation of telemedicine services and (ii) perceived benefits and challenges related to the use of telemedicine across the Italian National Health Service.Methods:An online cross-sectional survey was distributed to professionals working within 308 healthcare organisations in different Italian regions. Quantitative and qualitative data were collected through a self-administered questionnaire (June-September 2021). Responses were analysed using summary statistics and thematic analysis.Results:Key factors driving the adoption of telemedicine have been grouped into (i) organisational drivers (reduce the virus spread-80%; enhance care quality and efficiency-61%), (ii) technological drivers (ease of use-82%; efficacy and reliability-64%; compliance with data governance regulations-64%) and (iii) regulatory drivers (regulations’ semplification-84%). Nearly all respondents perceive telemedicine as useful in improving patient care (96%). The main benefits reported by respondents are shorter waiting lists, reduced Emergency Department attendance, decreased patient and clinician travel, and more frequent patient-doctor interactions. However, only five respondents believe that telemedicine services are more effective than traditional care and 66% of the healthcare professionals believe that telemedicine can’t completely substitute in-person visits due to challenges with physical examination and patient-doctor relationships. Other reported challenges include poor quality and interoperability of telemedicine platforms and scarce integration of telemedicine with traditional care services. Moreover, healthcare professionals believe that some groups of patients experience difficulties in accessing and using the technologies due to socio-cultural factors, technological and linguistic challenges and the absence of caregivers.Conclusions:Respondents believe that telemedicine can be useful to complement and augment traditional care.However, many challenges still need to be overcome to fully consider telemedicine a standard of care.Strategies that could help address these challenges include additional regulations on data governance and reimbursements, evidence-based guidelines for the use of telemedicine, greater integration of tools and processes, patient-centred training for clinicians, patient-facing material to assist patients in navigating virtual sessions, different language options, and greater involvement of caregivers in the care process.
The association between menstrual cycle abnormalities and the COVID-19 vaccine
Authors: Khalil Asma , Sultan Mada , Raggam Albara , Khan Mohammed
Published: December 2022

Introduction
COVID-19 vaccines are considered safe and offer great protection from the virus. However, they can have several side effects including fever, fatigue, and local pain and swelling. Recently a trend in the drug adverse events reporting systems showed an increased number of female vaccine recipients having menstrual cycle abnormalities post-vaccination.
Aim
This study aimed to determine the association between menstrual cycle abnormalities and the COVID vaccines.
Subjects and methods
This is a cross-sectional study conducted among reproductive-age women aged between 18 and 50 years old. A self-administered questionnaire was distributed among women using an online survey. The questionnaire includes basic demographic characteristics, the number of received vaccine doses, the type of vaccines, and the changes in menstrual cycles after receiving the COVID-19 vaccine.
Results
700 reproductive age women met the inclusion criteria. After the first dose there was a significant change in menstrual cycle regularity P-value 0.009 (95% confidence interval 0.402-0.881) and odds ratio of (0.595). However, there was no significant change after the second and third dose p-value 0.065 and 0.055 respectively. The data also indicated a significant change in the menses flow; P-value (<0.001), with more women experiencing a reduction or increase in their period flow.
Conclusion
This study identifies a possible association between menstrual cycle abnormalities and COVID-19 vaccination. This was noted most after the first dose. Menstrual cycle abnormalities were in the form of changes in cycle length, duration of bleeding, premenstrual symptoms, and having missed periods. Menstrual changes are not uncommon but are transient and should not be alarming for women yet awareness about this experience is an instrumental factor to build trust in the COVID-19 vaccine.
Unmixing of PAHs in Contaminated Sediments Using Positive Matrix Factorization
Authors: Saba Tarek
Published: December 2022

One of the challenges to apportioning PAH-related remedy costs at contaminated sediment Sites is unmixing of PAH fingerprints to PAH source classes (petrogenic, pyrogenic, and runoff, a derivative of petrogenic and pyrogenic sources). Unmixing of PAHs can be challenged by lack of source samples, different PAH signatures associated with different sources (or sometimes the same source), historical PAH sources long removed, urban sediment movement by boat traffic and, in turn, PAHs mixing, and weathering effects on PAH fingerprints. This work demonstrates using Positive Matrix Factorization (PMF) as a method to unmix PAH fingerprints to its source classes, while overcoming these challenges. A large PAH dataset (over 700 samples) assembled from contaminated urban sediment sites was used as an input to PMF. Using a 3-Factor PMF analysis, a petrogenic, pyrogenic, and runoff/weathered PAH end member fingerprints were identified. Different numerical mixing percentages of the PMF-identified end member sources were able to replicate the site-measured PAH fingerprints, with the percent contribution of each of the end members to each sediment sample calculated. In addition, the analysis calculated the percent contribution of each end member source to each PAH compound (e.g., benzo([a]pyrene). The demonstrated work provides a method to satisfy the unmixing of PAH fingerprints to its source classes, as a step towards apportioning of PAH contamination.
Trend analysis in gridded rainfall data using Mann –Kendall and Spearman’s rho tests in Kesinga catchment of Mahanadi river basin, India
Authors: pereli Pereli chinna vani , Sahoo B. C. , Paul J. C. , Sahu A. P , Mohapatra A. K. B.
Published: December 2022

The article provides a long-term trend analysis of the Kesinga catchment daily gridded rainfall at a (0.25°*0.25°) high spatial resolution from the years 1901 to 2020 (120 years). The trend in seasonal and annual rainfall was therefore detected using nonparametric statistical tests spearman’s rho and Mann-Kendall, smoothing curve, Sen’s slope test, and plot of innovative rend analysis. The results showed that statistically significant trends (SSTs) had a pattern with both positive (increasing) and negative (decreasing) trends, with positive and negative trends evident in the winter and negative trends shown in the monsoon, PREMON, and annual seasons. The middle of the study area revealed the highest negative trend and the lower Kesinga catchment showed the lowest negative annual rainfall trend. The entire Kesinga catchment, the seasonal data and annual rainfall both showed statistically significant and non-significant patterns. Consistently, the MK and SR tests were both conducted at the validated significance level. In various contexts, the massive trend that has occurred with statistical significance were negative (70%). If the current pattern continues in the future, then there will be a scarcity of water and more strain on the control of water resources at the given grids in corresponding temporal scales.