bluuebunny/crossref_metadata_2025 huggingface dataset:
What Are the Challenges Faced by Village Doctors in Provision of Basic Public Health Services in Shandong, China? A Qualitative Study
Authors: Wang Qian , Kong Yuejia , Sun Jiyao , Zhang Yue , Yuan Linlin , Wang Jian
Published: July 2019

Background: Village doctors, as gatekeepers for the health of rural residents in China, are confronted with adversity in providing the basic public health services (BPHS), which has significantly impeded them from providing high quality BPHS. This study aimed to explore the obstacles and difficulties faced by village doctors in order to improve the quality and efficiency of BPHS provision and increase the health level of the population. Methods: In-depth interviews were employed to conduct this qualitative study. A total of 51 village doctors in four cities of Shandong Province were interviewed. The interviews were transcribed, anonymized, and imported into NVivo11.0 to facilitate management. Thematic framework analysis employing the constant comparison method was applied to the data analysis. Results: The main challenges faced by village doctors comprised the shortage, gender imbalance, and poor education of village doctors; older village doctors in some villages; low income; lack of social security; inappropriate performance assessment; inadequate professional BPHS training; heavy workload; and insufficient cooperation from rural residents, which have exacerbated the quality, efficiency, and accessibility of BPHS to some extent. Conclusions: Village doctors, as the important BPHS providers in rural Shandong, are facing a wide range of challenges. It is urgent for government officials and policy makers to consider these challenges and concentrate on improving the quality of BPHS provision by developing relevant and practical strategies.
The Association between Bisphenol A Exposure and Obesity in Children—A Systematic Review with Meta-Analysis
Authors: Kim Ka Young , Lee Eunil , Kim Yanghee
Published: July 2019

Bisphenol A (BPA) is an environmental chemical that has adverse effects on health, probably causing childhood obesity. However, this association remains controversial, and it is difficult to find evidence for direct causality between environmental exposure and disease using epidemiological studies. In this study, we sought to elucidate the possible causality between BPA exposure and childhood obesity by conducting two meta-analyses showing bidirectional associations, including exposure effect by obesity and obesity risk by exposure. Articles published up to September 2017 were searched in PubMed, Embase, and Cochrane Library. We evaluated observational studies that included measurements of urinary BPA concentration and BMI or body weight. Of 436 articles, a total of 13 studies were included in the meta-analysis. Two meta-analyses were performed to investigate the association between BPA exposure and childhood obesity. The results showed that the relatively high-exposed group had a significantly higher risk of childhood obesity than the relatively low-exposed group (odds ratio = 1.566, 95% confidence interval [CI]: 1.097 to 2.234, p = 0.014). However, the obese group showed no significant difference in the BPA concentration when compared to the normal group (standardized mean difference = 0.166, 95% CI: −0.121 to 0.453, p = 0.257). This study suggested possible causality between BPA exposure and childhood obesity using data from epidemiological studies and showed that BPA exposure itself increased the risk of obesity in children.
Glucagon, GLP-1 and Thermogenesis
Authors: González-García Ismael , Milbank Edward , Diéguez Carlos , López Miguel , Contreras Cristina
Published: July 2019

Brown adipose tissue (BAT) thermogenesis is a conserved mechanism to maintain body temperature in mammals. However, since BAT contribution to energy expenditure can represent a relevant modulator of metabolic homeostasis, many studies have focused on the nervous system and endocrine factors that control the activity of this tissue. There is long-established evidence that the counter-regulatory hormone glucagon negatively influences energy balance, enhances satiety, and increases energy expenditure. Despite compelling evidence showing that glucagon has direct action on BAT thermogenesis, recent findings are questioning this conventional attribute of glucagon action. Glucagon like peptide-1 (GLP-1) is an incretin secreted by the intestinal tract which strongly decreases feeding, and, furthermore, improves metabolic parameters associated with obesity and diabetes. Therefore, GLP-1 receptors (GLP-1-R) have emerged as a promising target in the treatment of metabolic disorders. In this short review, we will summarize the latest evidence in this regard, as well as the current therapeutic glucagon- and GLP-1-based approaches to treating obesity.
Hair Growth Promoting Effect of 4HGF Encapsulated with PGA Nanoparticles (PGA-4HGF) by β-Catenin Activation and Its Related Cell Cycle Molecules
Authors: Lee Hye-Ji , Kwon Ha-Kyoung , Kim Hye Su , Kim Moon Il , Park Hye-Jin
Published: July 2019

Poly-γ-glutamic acid (γ-PGA)-based nanoparticles draw remarkable attention as drug delivery agents due to their controlled release characteristics, low toxicity, and biocompatibility. 4HGF is an herbal mixture of Phellinus linteus grown on germinated brown rice, Cordyceps militaris grown on germinated soybeans, Polygonum multiflorum, Ficus carica, and Cocos nucifera oil. Here, we encapsulated 4HGF within PGA-based hydrogel nanoparticles, prepared by simple ionic gelation with chitosan, to facilitate its penetration into hair follicles (HFs). In this study, we report the hair promoting activity of 4HGF encapsulated with PGA nanoparticles (PGA-4HGF) and their mechanism, compared to 4HGF alone. The average size of spherical nanoparticles was ~400 nm in diameter. Continuous release of PGA-4HGF was observed in a simulated physiological condition. As expected, PGA-4HGF treatment increased hair length, induced earlier anagen initiation, and elongated the duration of the anagen phase in C57BL/6N mice, compared with free 4HGF treatment. PGA-4HGF significantly increased dermal papilla cell proliferation and induced cell cycle progression. PGA-4HGF also significantly increased the total amount of β-catenin protein expression, a stimulator of the anagen phase, through induction of cyclinD1 and CDK4 protein levels, compared to free 4HGF treatment. Our findings underscore the potential of PGA nanocapsules to efficiently deliver 4HGF into HFs, hence promoting hair-growth. Therefore, PGA-4HGF nanoparticles may be promising therapeutic agents for hair growth disorders.
Plant Phytochromes and their Phosphorylation
Authors: Hoang Quyen T. N. , Han Yun-Jeong , Kim Jeong-Il
Published: July 2019

Extensive research over several decades in plant light signaling mediated by photoreceptors has identified the molecular mechanisms for how phytochromes regulate photomorphogenic development, which includes degradation of phytochrome-interacting factors (PIFs) and inactivation of COP1-SPA complexes with the accumulation of master transcription factors for photomorphogenesis, such as HY5. However, the initial biochemical mechanism for the function of phytochromes has not been fully elucidated. Plant phytochromes have long been known as phosphoproteins, and a few protein phosphatases that directly interact with and dephosphorylate phytochromes have been identified. However, there is no report thus far of a protein kinase that acts on phytochromes. On the other hand, plant phytochromes have been suggested as autophosphorylating serine/threonine protein kinases, proposing that the kinase activity might be important for their functions. Indeed, the autophosphorylation of phytochromes has been reported to play an important role in the regulation of plant light signaling. More recently, evidence that phytochromes function as protein kinases in plant light signaling has been provided using phytochrome mutants displaying reduced kinase activities. In this review, we highlight recent advances in the reversible phosphorylation of phytochromes and their functions as protein kinases in plant light signaling.
Insights into the Periplasmic Proteins of Acinetobacter baumannii AB5075 and the Impact of Imipenem Exposure: A Proteomic Approach
Authors: Scribano Daniela , Marzano Valeria , Levi Mortera Stefano , Sarshar Meysam , Vernocchi Pamela , Zagaglia Carlo , Putignani Lorenza , Palamara Anna Teresa , Ambrosi Cecilia
Published: July 2019

Carbapenem-resistant Acinetobacter baumannii strains cause life-threatening infections due to the lack of therapeutic options. Although the main mechanisms underlying antibiotic-resistance have been extensively studied, the general response to maintain bacterial viability under antibiotic exposure deserves to be fully investigated. Since the periplasmic space contains several proteins with crucial cellular functions, besides carbapenemases, we decided to study the periplasmic proteome of the multidrug-resistant (MDR) A. baumannii AB5075 strain, grown in the absence and presence of imipenem (IMP). Through the proteomic approach, 65 unique periplasmic proteins common in both growth conditions were identified: eight proteins involved in protein fate, response to oxidative stress, energy metabolism, antibiotic-resistance, were differentially expressed. Among them, ABUW_1746 and ABUW_2363 gene products presented the tetratricopeptide repeat motif, mediating protein-protein interactions. The expression switch of these proteins might determine specific protein interactions to better adapt to changing environmental conditions. ABUW_2868, encoding a heat shock protein likely involved in protection against oxidative stress, was upregulated in IMP-exposed bacteria. Accordingly, the addition of periplasmic proteins from A. baumannii cultured with IMP increased bacterial viability in an antioxidant activity assay. Overall, this study provides the first insights about the composition of the periplasmic proteins of a MDR A. baumannii strain, its biological response to IMP and suggests possible new targets to develop alternative antibiotic drugs.
The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release
Authors: Faizan Muhammad , Niazi Kifayat Ullah Khan , Muhammad Niaz , Hu Yongxia , Wang Yanyan , Lin Dezhi , Liu Yuanyuan , Zhang Weiqiang , Gao Ziwei
Published: July 2019

The pharmaceutical clay montmorillonite (MMT) is, for the first time, explored as a carbon monoxide-releasing material (CORMat). MMT consists of silicate double layered structure; its exfoliation feature intercalate the CORM-2 [RuCl(μ-Cl)(CO)3]2 inside the layers to suppress the toxicity of organometallic segment. The infrared spectroscopy (IR) confirmed the existence of ruthenium coordinated carbonyl ligand in MMT layers. The energy-dispersive X-ray spectroscopy (EDX) analysis showed that ruthenium element in this material was about 5%. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images showed that the layer-structure of MMT has been maintained after loading the ruthenium carbonyl segment. Moreover, the layers have been stretched out, which was confirmed by X-ray diffraction (XRD) analysis. Thermogravimetric (TG) curves with huge weight loss around 100–200 °C were attributed to the CO hot-release of ruthenium carbonyl as well as the loss of the adsorbed solvent molecules and the water molecules between the layers. The CO-liberating properties have been assessed through myoglobin assay. The horse myoglobin test showed that the material could be hydrolyzed to slowly release carbon monoxide in physiological environments. The half-life of CO release was much longer than that of CORM-3, and it has an excellent environmental tolerance and slow release effect.
Unravelling the Role of Trophoblastic-Derived Extracellular Vesicles in Regulatory T Cell Differentiation
Authors: Kovács Árpád Ferenc , Fekete Nóra , Turiák Lilla , Ács András , Kőhidai László , Buzás Edit I. , Pállinger Éva
Published: July 2019

Regulatory T cells (Treg) are mandatory elements in the maintenance of human pregnancy, but their de novo differentiation has not been completely exposed. HSPE1 chaperone expressing trophoblast cells may have a role in it. Trophoblast-derived extracellular vesicles (EVs), either at the feto–maternal interface or in circulation, target CD4+ T cells. We hypothesized that HSPE1-associated trophoblastic cell line (BeWo)-derived EVs are active mediators of Treg cell differentiation. We proved at first that recombinant HSPE1 promote human Treg cell differentiation in vitro. Developing a CRISPR-Cas9 based HSPE1 knockout BeWo cell line we could also demonstrate, that EV-associated HSPE1 induces Treg development. Next-generation sequencing of miRNA cargo of BeWo-EVs characterized the regulatory processes of Treg polarization. By the use of single-cell transcriptomics analysis, seven Treg cell subtypes were distinguished and we demonstrated for the first time that the expression level of HSPE1 was Treg subtype dependent, and CAPG expression is characteristic to memory phenotype of T cells. Our data indicate that HSPE1 and CAPG may be used as markers for identification of Treg subtypes. Our results suggest, that trophoblastic-derived iEVs-associated HSPE1 and miRNA cargo have an important role in Treg cell expansion in vitro and HSPE1 is a useful marker of Treg subtype characterization.
Label-Free Proteomic Analysis of Molecular Effects of 2-Methoxy-1,4-naphthoquinone on Penicillium italicum
Authors: Guo Meixia , Zhang Xiaoyong , Li Meiying , Li Taotao , Duan Xuewu , Zhang Dandan , Hu Lianmei , Huang Riming
Published: July 2019

Penicillium italicum is the principal pathogen causing blue mold of citrus. Searching for novel antifungal agents is an important aspect of the post-harvest citrus industry because of the lack of higher effective and low toxic antifungal agents. Herein, the effects of 2-methoxy-1,4-naphthoquinone (MNQ) on P. italicum and its mechanism were carried out by a series of methods. MNQ had a significant anti-P. italicum effect with an MIC value of 5.0 µg/mL. The label-free protein profiling under different MNQ conditions identified a total of 3037 proteins in the control group and the treatment group. Among them, there were 129 differentially expressed proteins (DEPs, up-regulated > 2.0-fold or down-regulated < 0.5-fold, p < 0.05), 19 up-regulated proteins, 26 down-regulated proteins, and 67 proteins that were specific for the treatment group and another 17 proteins that were specific for the control group. Of these, 83 proteins were sub-categorized into 23 hierarchically-structured GO classifications. Most of the identified DEPs were involved in molecular function (47%), meanwhile 27% DEPs were involved in the cellular component and 26% DEPs were involved in the biological process. Twenty-eight proteins identified for differential metabolic pathways by KEGG were sub-categorized into 60 classifications. Functional characterization by GO and KEGG enrichment results suggests that the DEPs are mainly related to energy generation (mitochondrial carrier protein, glycoside hydrolase, acyl-CoA dehydrogenase, and ribulose-phosphate 3-epimerase), NADPH supply (enolase, pyruvate carboxylase), oxidative stress (catalase, glutathione synthetase), and pentose phosphate pathway (ribulose-phosphate 3-epimerase and xylulose 5-phosphate). Three of the down-regulated proteins selected randomly the nitro-reductase family protein, mono-oxygenase, and cytochrome P450 were verified using parallel reaction monitoring. These findings illustrated that MNQ may inhibit P. italicum by disrupting the metabolic processes, especially in energy metabolism and stimulus response that are both critical for the growth of the fungus. In conclusion, based on the molecular mechanisms, MNQ can be developed as a potential anti-fungi agent against P. italicum.
The Number of Liver Galectin-3 Positive Cells Is Dually Correlated with NAFLD Severity in Children
Authors: de Oliveira Felipe Leite , Panera Nadia , De Stefanis Cristiano , Mosca Antonella , D’Oria Valentina , Crudele Annalisa , De Vito Rita , Nobili Valerio , Alisi Anna
Published: July 2019

Non-alcoholic fatty liver disease (NAFLD) is a complex disease ranging from steatosis to non-alcoholic steatohepatitis (NASH). Galectin-3 (Gal-3), which is a β-galactoside binding protein, has been associated with liver fibrosis, but its role in NAFLD remains elusive. We investigated the expression of Gal-3 in liver resident cells and its potential association with liver damage in 40 children with biopsy-proven NAFLD. We found that several liver cells expressed Gal-3. The number of total Gal-3 positive cells decreased with the severity of disease and the cells were correlated with the presence of steatosis and the diagnosis of NASH. CD68 macrophages expressed Gal-3 but the number CD68/Gal-3 positive cells was significantly reduced in patients diagnosed with steatosis and NASH. Triple CD68/CD206/Gal-3, which represented the subpopulation of M2 macrophages, were mainly present in patients without NASH, and clearly reduced in patients with steatosis and NASH. On the contrary, the number of α-smooth muscle actin (SMA)/Gal-3 positive cells increased with the severity of fibrosis in children with NAFLD. Our data demonstrated that the number of Gal-3 positive cells was associated with tissue damage in different ways, which suggests a dual role of this protein in the pathogenesis of pediatric NAFLD, even if the role of Gal-3 deserves further studies.
Metabolome of Exosomes: Focus on Vesicles Released by Cancer Cells and Present in Human Body Fluids
Authors: Zebrowska Aneta , Skowronek Agata , Wojakowska Anna , Widlak Piotr , Pietrowska Monika
Published: July 2019

Exosomes and other classes of extracellular vesicles (EVs) have gained interest due to their role in cell-to-cell communication. Knowledge of the molecular content of EVs may provide important information on features of parental cells and mechanisms of cross-talk between cells. To study functions of EVs it is essential to know their composition, that includes proteins, nucleic acids, and other classes biomolecules. The metabolome, set of molecules the most directly related to the cell phenotype, is the least researched component of EVs. However, the metabolome of EVs circulating in human blood and other bio-fluids is of particular interest because of its potential diagnostic value in cancer and other health conditions. On the other hand, the metabolome of EVs released to culture media in controlled conditions in vitro could shed light on important aspects of communication between cells in model systems. This paper summarizes the most common approaches implemented in EV metabolomics and integrates currently available data on the composition of the metabolome of EVs obtained in different models with particular focus on human body fluids and cancer cells.
Changes in Gene Expression and Metabolite Profiles in Platanus acerifolia Leaves in Response to Feeding Damage Caused by Corythucha ciliata
Authors: Li Fengqi , Wu Chunyan , Dewer Youssef , Li Du , Qu Cheng , Luo Chen
Published: July 2019

The sycamore lace bug, Corythucha ciliata (Say) is a highly invasive pest insect that feeds on sycamore trees (Platanus spp.) worldwide. The interaction between Platanus species and this insect pest has not yet been studied at the molecular level. Therefore, a recent study was conducted to compare the gene expression and metabolite profiles of Platanus acerifolia leaves in response to C. ciliata feeding damage after 24 and 48 h. We employed high throughput RNA sequencing (RNA- seq) to identify a total of 2,828 significantly differentially expressed genes (DEGs) after C. ciliata feeding. In addition, 303 unigenes were found to be up-regulated at both time points. Moreover, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis showed that monoterpenoid biosynthesis, the linoleic acid metabolism pathway, and alpha- linolenic acid metabolism were the most prominent pathways among the DEGs. Further analysis of the metabolite profiles showed that nine metabolites were significantly different before and after C. ciliata damage. In addition, we analyzed DEGs detected in the P. acerifolia and C. ciliata interaction using Mapman. The terpene synthase gene family was also identified. We suggest that the results obtained from DEGs and metabolite analysis can provide important information for the identification of genes involved in the P. acerifolia–C. ciliata interaction, which might be necessary for controlling C. ciliata efficiently.
Population Dynamics of Spotted Wing Drosophila (Drosophila suzukii (Matsumura)) in Maine Wild Blueberry (Vaccinium angustifolium Aiton)
Authors: Drummond Francis , Ballman Elissa , Collins Judith
Published: July 2019

A long-term investigation of D. suzukii dynamics in wild blueberry fields from 2012–2018 demonstrates relative abundance is either still increasing or exhibiting periodicity seven years after the initial invasion. Relative abundance is determined by physiological date of first detection and air temperatures the previous winter. Date of first detection of flies does not determine date of fruit infestation. The level of fruit infestation is determined by year, fly pressure, and insecticide application frequency. Frequency of insecticide application is determined by production system. Non-crop wild fruit and predation influences fly pressure; increased wild fruit abundance results in increased fly pressure. Increased predation rate reduces fly pressure, but only at high abundance of flies, or when high levels of wild fruit are present along field edges. Male sex ratio might be declining over the seven years. Action thresholds were developed from samples of 92 fields from 2012–2017 that related cumulative adult male trap capture to the following week likelihood of fruit infestation. A two-parameter gamma density function describing this probability was used to develop a risk-based gradient action threshold system. The action thresholds were validated from 2016–2018 in 35 fields and were shown to work well in two of three years (2016 and 2017).
Temporal Dynamics of Host Use by Drosophila suzukii in California’s San Joaquin Valley: Implications for Area-Wide Pest Management
Authors: Wang Xingeng , Kaçar Gülay , Daane Kent
Published: July 2019

A major challenge to the area-wide management of Drosophila suzukii is understanding the fly’s host use and temporal dynamics, which may dictate local movement patterns. We determined D. suzukii’s seasonal host use in California’s San Joaquin Valley by sampling common crop and non-crop fruits in a temporal sequence of fruit ripening. We then evaluated the suitability of selected fruits as hosts. Drosophila suzukii emerged from both intact and damaged cherries during the cooler, early season period. Fly density remained low through the hot spring–summer period and re-surged as temperatures lowered in fall when the fly did not cause damage to intact peach, nectarine, plum, pear, grape, pomegranate, apple, persimmon and citrus (in order of ripening) but did emerge from the damaged fruits of these crops. The fly also emerged from two ornamental fruits (loquats and cactus) but was not found on wild plum and two endemic wild fruits (buckthorn and bitter berry). Drosophila suzukii completed development (egg to adult) on cactus, mandarin carpel, pomegranate seed, wild plum and buckthorn at survival rates similar to cherry (51.2–68.8%), whereas it had a lower survival rate on bitter cherry (33.2%), table grape (31.5%), raisin grape (26.5%), and wine grape (4.5%). The high acidity levels of grapes negatively affected the fly’s fitness. Among 10 cherry cultivars, survival rate was not affected by sugar content, but it decreased with increasing egg density per gram of fruit. Results suggest that in California’s San Joaquin Valley, the early season crops are most vulnerable, summer fruits ripen during a period of low pest pressure, and late season fruits, when damaged, serve to sustain D. suzukii’s populations in this region.
Bayesian Optimized Deep Convolutional Network for Electrochemical Drilling Process
Authors: Lu Yanfei , Wang Zengyan , Xie Rui , Liang Steven
Published: July 2019

Electrochemical machining is a promising non-traditional manufacturing process to make high-quality parts. The benefits of minimal thermally and mechanically induced stresses, free of burr, and a low surface roughness are appealing for industry and research institutes. However, the combined chemical reaction, electric field, fluid mechanics, and material properties involve a significant number of independent parameters which are difficult to analyze in order to draw comprehensive conclusions. To our current knowledge, process responses such as the material removal rate, optimal feed rate, and cutting profile cannot be represented accurately by analytical solutions. In recent years, deep learning has had tremendous success in analyzing sophisticated systems. The improved computation efficiency and reduced size of the training dataset required for deep learning have enabled various prediction models in the manufacturing industry. In this paper, a new approach is developed using the deep convolutional network with the Bayesian optimization algorithm to predict the diameters of the drilled hole from an electrochemical machining process. The Keras application programming interface (API) was used to build the deep convolutional network; the feed rate, pulse-on time, and voltage were used as input parameters to provide a fair comparison with a neural network from previous research. Random dropout layers were added to prevent overfitting of the network. Instead of tuning the network parameter by trial and error, the Bayesian parameter optimization algorithm was implemented to find the optimal set of parameters of the deep convolutional network that yields the minimum mean square error. The proposed algorithm was compared with a previously developed neural network with partially embedded physical knowledge. Improved training speed and accuracy were observed in comparison with the traditional neural network. The prediction model using the proposed deep learning algorithm demonstrated better prediction accuracy and provided a more systematic way to select the hyperparameter for the deep convolutional network.
Blockchains for Secure Digitized Medicine
Authors: Shuaib Khaled , Saleous Heba , Shuaib Karim , Zaki Nazar
Published: July 2019

Blockchain as an emerging technology has been gaining in popularity, with more possible applications to utilize the technology in the near future. With the offer of a decentralized, distributed environment without the need for a third trusted party (TTP), blockchains are being used to solve issues in systems that are susceptible to cyberattacks. One possible field that could benefit from blockchains that researchers have been focusing on is healthcare. Current healthcare information systems face several challenges, such as fragmented patient data, centralized systems which are viewed as single points of attacks, and the lack of patient-oriented services. In this paper, we investigate and analyze recent literature related to the use of blockchains to tackle issues found in modern healthcare information systems. This is done to understand issues that researchers commonly focus on, to discover remaining areas of concern in any proposed solution, and to understand the possible directions of the integration of blockchains in healthcare and personalized medicine. Background information regarding blockchains and existing healthcare information systems is reviewed, followed by the methodology used in the preparation of this review, where the research questions to consider are stated. Afterwards, an analysis of the results is provided, concluding with a discussion of the remaining issues that need to be focused on, and how blockchains could benefit the healthcare sector and empower personalized medicine.
Does Fiscal Decentralization Encourage Corruption in Local Governments? Evidence from Indonesia
Authors: Alfada Anisah
Published: July 2019

This study examines the effects of fiscal decentralization on corruption by analyzing whether the degree of fiscal decentralization facilitates or mitigates the number of corruption cases in Indonesia’s local governments. The research utilizes a panel data model and a system Generalized Method of Moments (GMM) estimator to assess the degree of fiscal decentralization on corruption in 19 provinces for the period between 2004 and 2014. The estimation results reveal that the degree of fiscal decentralization, both expenditure and tax revenue sides, drives a growing number of corruption cases in local governments. A lack of human capital capacity, low transparency and accountability, and a higher dependency on intergovernmental grants from the central government may worsen the adverse effects of corruption. Our results suggest that a more heterogeneous population and higher political stability mitigate the adverse effects of corruption. Furthermore, this is the first corruption study in Indonesia to create corruption measures from the number of corruption cases investigated by the Indonesia Corruption Eradication Commission as well as extensive, provincial-level government financial data. As a result of using these different datasets, this research advances existing empirical studies and makes policy recommendations for the local governments in Indonesia.
Cultivar-Specific Performance and Qualitative Descriptors for Butterhead Salanova Lettuce Produced in Closed Soilless Cultivation as a Candidate Salad Crop for Human Life Support in Space
Authors: El-Nakhel Christophe , Giordano Maria , Pannico Antonio , Carillo Petronia , Fusco Giovanna Marta , De Pascale Stefania , Rouphael Youssef
Published: July 2019

Plant production is crucial for space journeys self-autonomy by contributing to the dietary intake necessary to sustain the physical and psychological well-being of space colonists, as well as for contributing to atmospheric revitalization, water purification and waste product recycling. Choosing the appropriate cultivar is equally important as the species selection, since cultivar influences the obtained fresh biomass, water use efficiency (WUE), growing cycle duration, qualitative features and postharvest performance. Two differently pigmented butterhead Lactuca sativa L. (red and green Salanova) cultivars were assessed in terms of morphometric, mineral, bioactive and physiological parameters. The experiment was carried out in a controlled environment growth chamber using a closed soilless system (nutrient film technique). Red Salanova registered a biomass of 130 g at harvest, which was 22.1% greater than green Salanova, and a water uptake of 1.42 L during the full growing period corresponding to WUE of 91.9 g L−1, which was 13.8% higher than that of green Salanova. At harvest, green Salanova had accumulated more P, K, Ca, Mg and 37.2% more nitrate than red Salanova, which however had higher relative water content, leaf total and osmotic potential and higher SPAD index. Red Salanova also exhibited at harvest around two-fold higher lipophilic antioxidant activity and total phenols, and around six-fold higher total ascorbic acid levels. These latter characteristics improved the antioxidant capacity of red Salanova enabling it to use light more efficiently and deliver better overall performance and yield than green Salanova. Moreover, the higher phenolics and total ascorbic acid contents of red Salanova constitute natural sources of antioxidants for enriching the human diet and render it an optimal candidate cultivar for near-term missions.
Design and Manufacturing Method of Fundamental Beam Mode Shaper for Adapted Laser Beam Profile in Laser Material Processing
Authors: Bischoff Christian , Völklein Friedemann , Schmitt Jana , Rädel Ulrich , Umhofer Udo , Jäger Erwin , Lasagni Andrés Fabián
Published: July 2019

Many laser material processing applications require an optimized beam profile, e.g., ring shape or Top-Hat profiles with homogeneous intensity distribution. In this study, we show a beam shaping concept leading to a phase shifting element with binary height profile as well as a very low periodicity with near diffraction limited spot size. Further advantages of so-called Fundamental Beam Mode Shaping (FBS) elements are the simplified handling, and a high efficiency and homogeneity. The calculated height profile of FBS elements are transferred in fused silica substrates using a combination of microlithography technologies, reactive ion etching (RIE) and ion beam etching (IBE). The experiments demonstrated a linear relation between the etching depth after RIE and IBE. The optical evaluation of the manufactured FBS beam mode shaper confirmed the presented concept design.
Broadband Anisotropy in Terahertz Metamaterial With Single-Layer Gap Ring Array
Authors: Xia Liangping , Cui Hong-Liang , Zhang Man , Dang Suihu , Du Chunlei
Published: July 2019

To convert the polarization of terahertz waves pumped by a femtosecond laser in a terahertz time domain system, a broadband anisotropic metamaterial is proposed. The metamaterial is constructed with a single-layer gapped metallic ring array, which supports different resonant modes in orthogonal directions. With the aid of simulations and measurements, the anisotropy of the terahertz transmission is demonstrated and discussed. The experimental results of THz transmission in the metamaterial indicate that the anisotropic band is as wide as 0.56 THz, which accords well with our theoretical prediction.
New Findings on Multilayer Silicene on Si(111)√3×√3R30°–Ag Template
Authors: De Padova Paola , Generosi Amanda , Paci Barbara , Ottaviani Carlo , Quaresima Claudio , Olivieri Bruno , Kopciuszyński Marek , Żurawek Lucyna , Zdyb Ryszard , Krawiec Mariusz
Published: July 2019

We report new findings on multilayer silicene grown on Si(111)√3 × √3 R30°–Ag template, after the recent first compelling experimental evidence of its synthesis. Low-energy electron diffraction, reflection high-energy electron diffraction, and energy-dispersive grazing incidence X-ray diffraction measurements were performed to show up the fingerprints of √3 × √3 multilayer silicene. Angle-resolved photoemission spectroscopy displayed new features in the second surface Brillouin zone, attributed to the multilayer silicene on Si(111)√3 × √3 R30°–Ag. Band-structure dispersion theoretical calculations performed on a model of three honeycomb stacked layers, silicene grown on Si(111)√3 × √3 R30°-Ag surface confirm the experimental results.
On the Application of a Diffusive Memristor Compact Model to Neuromorphic Circuits
Authors: Cisternas Ferri Agustín , Rapoport Alan , Fierens Pablo I. , Patterson German A. , Miranda Enrique , Suñé Jordi
Published: July 2019

Memristive devices have found application in both random access memory and neuromorphic circuits. In particular, it is known that their behavior resembles that of neuronal synapses. However, it is not simple to come by samples of memristors and adjusting their parameters to change their response requires a laborious fabrication process. Moreover, sample to sample variability makes experimentation with memristor-based synapses even harder. The usual alternatives are to either simulate or emulate the memristive systems under study. Both methodologies require the use of accurate modeling equations. In this paper, we present a diffusive compact model of memristive behavior that has already been experimentally validated. Furthermore, we implement an emulation architecture that enables us to freely explore the synapse-like characteristics of memristors. The main advantage of emulation over simulation is that the former allows us to work with real-world circuits. Our results can give some insight into the desirable characteristics of the memristors for neuromorphic applications.
The Evolution of Electron Dispersion in the Series of Rare-Earth Tritelluride Compounds Obtained from Their Charge-Density-Wave Properties and Susceptibility Calculations
Authors: Vorobyev Pavel A. , Grigoriev Pavel D. , Kesharpu Kaushal K. , Khovaylo Vladimir V.
Published: July 2019

We calculated the electron susceptibility of rare-earth tritelluride compounds RTe3 as a function of temperature, wave vector, and electron-dispersion parameters. Comparison of the results obtained with the available experimental data on the transition temperature and on the wave vector of a charge-density wave in these compounds allowed us to predict the values and evolution of electron-dispersion parameters with the variation of the atomic number of rare-earth elements (R).
Influence of Waste Engine Oil Addition on the Properties of Zeolite-Foamed Asphalt
Authors: Woszuk Agnieszka , Wróbel Michał , Franus Wojciech
Published: July 2019

The previous studies on asphalt mix and asphalt with waste engine oil addition indicate the possibility of using this type of waste material for the construction of road pavements. The research presented in this paper aimed at the preliminary assessment of possible waste engine oil (WEO) addition to the asphalts foamed with water-soaked zeolites. In this research, synthetic zeolite Na-P1 and natural clinoptilolite were used. In order to improve the foaming effect, the zeolites were soaked with water before dispensing to the asphalt, in the amount of 75% asphalt weight for Na-P1 and 25% for clinoptilolite. The tests were performed for one type of waste engine oil—5W40 and two type of binders: 20/30 and polymer modified 25/55-60. The asphalt parameters such as the dynamic viscosity, penetration and softening point were determined with the addition of WEO and zeolites in the concentration of 0%, 3%, 5%, 7% for both materials. It was found that the WEO addition lowers the viscosity and softening point of asphalt but increases penetration. The zeolite addition affected the change of these parameters to a minor extent or was statistically irrelevant. The chemical analysis of the asphalt samples with WEO addition performed with the X-ray Fluorescence method did not show a significant amount of heavy metals which would increase the probability of low-temperature cracking. The analysis of the results indicates the possibility of using zeolite-foamed asphalt technology with WEO addition.
Identification of the Destruction Process in Quasi Brittle Concrete with Dispersed Fibers Based on Acoustic Emission and Sound Spectrum
Authors: Logoń Dominik
Published: July 2019

The paper presents the identification of the destruction process in a quasi-brittle composite based on acoustic emission and the sound spectrum. The tests were conducted on a quasi-brittle composite. The sample was made from ordinary concrete with dispersed polypropylene fibers. The possibility of identifying the destruction process based on the acoustic emission and sound spectrum was confirmed and the ability to identify the destruction process was demonstrated. It was noted that in order to recognize the failure mechanisms accurately, it is necessary to first identify them separately. Three- and two-dimensional spectra were used to identify the destruction process. The three-dimensional spectrum provides additional information, enabling a better recognition of changes in the structure of the samples on the basis of the analysis of sound intensity, amplitudes, and frequencies. The paper shows the possibility of constructing quasi-brittle composites to limit the risk of catastrophic destruction processes and the possibility of identifying those processes with the use of acoustic emission at different stages of destruction.
Emission Enhancement of Cu-Doped InP Quantum Dots through Double Shelling Scheme
Authors: Kim Hwi-Jae , Jo Jung-Ho , Yoon Suk-Young , Jo Dae-Yeon , Kim Hyun-Sik , Park Byoungnam , Yang Heesun
Published: July 2019

The doping of transition metal ions, such as Cu+ and Mn2+ into a quantum dot (QD) host is one of the useful strategies in tuning its photoluminescence (PL). This study reports on a two-step synthesis of Cu-doped InP QDs double-shelled with ZnSe inner shell/ZnS outer shell. As a consequence of the double shelling-associated effective surface passivation along with optimal doping concentrations, Cu-doped InP/ZnSe/ZnS (InP:Cu/ZnSe/ZnS) QDs yield single Cu dopant-related emissions with high PL quantum yields of 57–58%. This study further attempted to tune PL of Cu-doped QDs through the variation of InP core size, which was implemented by adopting different types of Zn halide used in core synthesis. As the first application of doped InP QDs as electroluminescent (EL) emitters, two representative InP:Cu/ZnSe/ZnS QDs with different Cu concentrations were then employed as active emitting layers of all-solution-processed, multilayered QD-light-emitting diodes (QLEDs) with the state-of-the-art hybrid combination of organic hole transport layer plus inorganic electron transport layers. The EL performances, such as luminance and efficiencies of the resulting QLEDs with different Cu doping concentrations, were compared and discussed.
Effect of Saturated Tea Waste and Perlite Particles on Early Age Hydration of High-Strength Cement Mortars
Authors: Jakhrani Sadam Hussain , Kim Hong Gi , Jeon In Kyu , Ryou Jae Suk
Published: July 2019

The main purpose of this work is to study the effect of saturated black tea waste and perlite on controlling the rapid heat of hydration in high-strength cement mortars at early ages. Tea waste and perlite were investigated as internal curing agents in different mixes. Mortar specimens with two different sizes of tea waste and perlite particles with 1 and 3% by volume of cement were added in different mixes to find their effect on early age hydration. The rising interior temperature, setting times, and strength parameters were evaluated. Results showed that the mix specimens that contained 3% tea waste and perlite particles significantly delayed the hydration process by minimizing internal temperature and extended setting times of different specimens. However, their usage had a slightly adverse impact on compressive and flexural strengths. It was observed that the specimens made with coarser particles of tea waste and perlite were more helpful to control early age rapid hydration than the specimens made with finer particles, whereas the specimens made with finer particles had slightly higher strengths than the specimens made with coarser particles. Hence, the coarser particles are recommended to be used in high-strength mortars to mitigate the early age rapid heat of hydration.
Some Properties of Interior and Closure in General Topology
Authors: Jung Soon-Mo , Nam Doyun
Published: July 2019

We present the necessary and sufficient conditions that the intersection of an open set and a closed set becomes either an open set or a closed set. As their dualities, we further introduce the necessary and sufficient conditions that the union of a closed set and an open set becomes either a closed set or an open set. Moreover, we give some necessary and sufficient conditions for the validity of U ∘ ∪ V ∘ = ( U ∪ V ) ∘ and U ¯ ∩ V ¯ = U ∩ V ¯ . Finally, we introduce a necessary and sufficient condition for an open subset of a closed subspace of a topological space to be open. As its duality, we also give a necessary and sufficient condition for a closed subset of an open subspace to be closed.
Is Scientific Medical Literature Related to Endometriosis Treatment Evidence-Based? A Systematic Review on Methodological Quality of Randomized Clinical Trials
Authors: Capraş Roxana-Denisa , Urda-Cîmpean Andrada Elena , Bolboacă Sorana D.
Published: July 2019

Background and objectives: Informed decision-making requires the ability to identify and integrate high-quality scientific evidence in daily practice. We aimed to assess whether randomized controlled trials (RCTs) on endometriosis therapy follow methodological criteria corresponding to the RCTs’ specific level in the hierarchy of evidence in such details to allow the reproduction and replication of the study. Materials and Methods: Using the keywords “therapy” and “endometriosis” and “efficacy” three bibliographic databases were searched for English written scientific articles published from 1 January 2008 to 3 March 2018. Only the randomized clinical trials (RCTs) were evaluated in terms of whether they provided the appropriate level of scientific evidence, equivalent to level 1, degree 1b in the hierarchy of evidence. A list of criteria to ensure study replication and reproduction, considering CONSORT guideline and MECIR standards, was developed and used to evaluate RCTs’ methodological soundness, and scores were granted. Three types of bias, namely selection bias (random sequence generation and allocation concealment), detection bias (blinding of outcome assessment), and attrition bias (incomplete outcome data) were also evaluated. Results: We found 387 articles on endometriosis therapy, of which 38 were RCTs: 30 double-blinded RCTs and 8 open-label RCTs. No article achieved the maximum score according to the evaluated methodological criteria. Even though 73.3% of the double-blinded RCTs had clear title, abstract, introduction, and objectives, only 13.3% provided precise information regarding experimental design and randomization, and also showed a low risk of bias. The blinding method was poorly reported in 43.3% of the double-blinded RCTs, while allocation concealment and random sequence generation were inadequate in 33.3% of them. Conclusions: None of the evaluated RCTs met all the methodological criteria, none had only a low risk of bias and provided sufficient details on methods and randomization to allow for the reproduction and replication of the study. Consequently, the appropriate level of scientific evidence (level 1, degree 1b) could not be granted. On endometriosis therapy, this study evaluated the quality of reporting in RCTs and not the quality of how the studies were performed.
Transport Characteristics of Fujifilm Ion-Exchange Membranes as Compared to Homogeneous Membranes АМХ and СМХ and to Heterogeneous Membranes MK-40 and MA-41
Authors: Sarapulova Veronika , Shkorkina Inna , Mareev Semyon , Pismenskaya Natalia , Kononenko Natalia , Larchet Christian , Dammak Lasaad , Nikonenko Victor
Published: July 2019

Ion-exchange membranes (IEMs) find more and more applications; the success of an application depends on the properties of the membranes selected for its realization. For the first time, the results of a comprehensive characterization of the transport properties of IEMs from three manufactures (Astom, Japan; Shchekinoazot, Russia; and Fujifilm, The Netherlands) are reported. Our own and literature data are presented and analyzed using the microheterogeneous model. Homogeneous Neosepta AMX and CMX (Astom), heterogeneous MA-41 and MK-40 (Shchekinoazot), and AEM Type-I, AEM Type-II, AEM Type-X, as well as CEM Type-I, CEM Type-II, and CEM Type-X produced by the electrospinning method (Fujifim) were studied. The concentration dependencies of the conductivity, diffusion permeability, as well as the real and apparent ion transport numbers in these membranes were measured. The counterion transport number characterizing the membrane permselectivity increases in the following order: CEM Type-I ≅ MA-41 < AEM Type-I < MK-40 < CMX ≅ CEM Type-II ≅ CEM Type-X ≅ AEM Type-II < AMX < AEM Type-X. It is shown that the properties of the AEM Type-I and CEM Type-I membranes are close to those of the heterogeneous MA-41 and MK-40 membranes, while the properties of Fujifilm Type-II and Type-X membranes are close to those of the homogeneous AMX and CMX membranes. This difference is related to the fact that the Type-I membranes have a relatively high parameter f2, the volume fraction of the electroneutral solution filling the intergel spaces. This high value is apparently due to the open-ended pores, formed by the reinforcing fabric filaments of the Type-I membranes, which protrude above the surface of these membranes.