bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation-Based Virtual Cycle for Multi-Level Airport Analysis
Authors: Mota Miguel , Di Bernardi Alejandro , Scala Paolo , Ramirez-Diaz Gabriel
Published: April 2018

The aeronautical industry is expanding after a period of economic turmoil. For this reason, a growing number of airports are facing capacity problems that can sometimes only be resolved by expanding infrastructure, with the inherent risks that such decisions create. In order to deal with uncertainty at different levels, it is necessary to have relevant tools during an expansion project or during the planning phases of new infrastructure. This article presents a methodology that combines simulation approaches with different description levels that complement each other when applied to the development of a new airport. The methodology is illustrated with an example that uses two models for an expansion project of an airport in The Netherlands. One model focuses on the operation of the airport from a high-level position, while the second focuses on other technical aspects of the operation that challenge the feasibility of the proposed configuration of the apron. The results show that by applying the methodology, analytical power is enhanced and the risk of making the wrong decisions is reduced. We identified the limitations that the future facility will have and the impact of the physical characteristics of the traffic that will operate in the airport. The methodology can be used for tackling different problems and studying particular performance indicators to help decision-makers take more informed decisions.
Histological and Bone Morphometric Evaluation of Osseointegration Aspects by Alkali Hydrothermally-Treated Implants
Authors: Umehara Hanako , Kobatake Reiko , Doi Kazuya , Oki Yoshifumi , Makihara Yusuke , Kubo Takayasu , Tsuga Kazuhiro
Published: April 2018

The purpose of this study was to investigate the osseointegration aspects of alkali-treated implants by histological and bone morphometric evaluations. Titanium implants (control) and alkali hydrothermally-treated titanium implants were used. Samples were evaluated by surface structure observation and wettability tests. Both implants were placed into the femurs of five rabbits, and osseointegration was assessed by measurement of removal torque (RT), bone–implant contact ratio (BIC), and bone tissue area ratio (BTA). Measurements were performed at the whole portion around the implant, the cortical bone portion, and the bone marrow portion. The surface structure of alkali-group showed nanoscale pores and super hydrophilicity. RT, BIC, and BTA values of alkali-group were significantly higher than those of control-group at the whole portion. In the cortical bone portion, the BIC value was higher in the alkali-group than in the control-group, and BTA showed no significant difference between groups. In the bone marrow portion, even though no significant difference between control and alkali groups, the latter had higher ratio of BIC than the former. These results indicate that alkali treated implants enhance bone integration in areas where the implant is in contact with bone, and may promote osteoinduction in the non-bone marrow portion.
Combined Effects of Synoptic-Scale Teleconnection Patterns on Summer Precipitation in Southern China
Authors: Wang Chao , Wang Lijuan
Published: April 2018

Using ERA-Interim daily reanalysis and precipitation data, the combined effects of East Asia-Pacific (EAP) and Silk Road (SR) teleconnection patterns on summer precipitation in Southern China were investigated on synoptic to sub-monthly timescales. Combined EAP and SR patterns lead to more persistent and extreme precipitation in the Yangtze River Valley (YRV) and exhibit an obvious zonal advance between the South Asia High (SAH) and Western Pacific Subtropical High (WPSH) prior to its onset. During typical combined events, an overlap between the SAH and WPSH remains in a favorable position for Persistent Extreme Precipitation (PEP). Furthermore, SR-induced acceleration of the westerly jet stream and extra positive vorticity advection provide persistent upper-level divergence for YRV precipitation. An anomalous EAP-related cyclone/anticyclone pair over East Asia induces enhanced low-level southwesterlies to the northern anticyclone flank and northerlies from the mid-latitudes, advecting anomalously abundant moisture toward the YRV, resulting in clear moisture convergence. Moreover, the strong ascent of warmer/moister air along a quasi-stationary front may be crucial for PEP. During decay, the SAH and WPSH diverge from each other and retreat to their normal positions, and the strong ascent of warmer/moister air rapidly weakens to dissipation, terminating PEP in the YRV.
Oncolytic Virotherapy versus Cancer Stem Cells: A Review of Approaches and Mechanisms
Authors: Chaurasiya Shyambabu , Chen Nanhai G. , Warner Susanne G.
Published: April 2018

A growing body of evidence suggests that a subset of cells within tumors are resistant to conventional treatment modalities and may be responsible for disease recurrence. These cells are called cancer stem cells (CSC), which share properties with normal stem cells including self-renewal, pluripotency, drug resistance, and the ability to maintain quiescence. While most conventional therapies can efficiently destroy rapidly dividing cancer cells comprising the bulk of a tumor, they often fail to kill the less abundant and quiescent CSCs. Furthermore, killing of only differentiated cells in the tumor may actually allow for enrichment of CSCs and thereby portend a bad prognosis. Therefore, targeting of CSCs is important to achieve long-term success in cancer therapy. Oncolytic viruses represent a completely different class of therapeutics that can kill cancer cells in a variety of ways, which differ from those of conventional therapies. Hence, CSCs that are inherently resistant to conventional therapies may be susceptible to oncolytic virus-mediated killing. Recent studies have shown that oncolytic viruses can efficiently kill CSCs in many types of cancer. Here, we discuss the mechanism through which CSCs can escape conventional therapies and how they may still be susceptible to different classes of oncolytic viruses. Furthermore, we provide a summary of recent studies that have tested oncolytic viruses on CSCs of different origins and discuss possible future directions for this fascinating subset of oncolytic virus research.
An Overview on Zeolite Shaping Technology and Solutions to Overcome Diffusion Limitations
Authors: Bingre Rogéria , Louis Benoît , Nguyen Patrick
Published: April 2018

Synthetic zeolites are widely used as catalysts/carriers for many petrochemical reactions and in refining processes. These materials are usually synthesized in a powder form and must be shaped prior to use in industrial reactors. This review presents the state-of-the-art of the zeolite shaping technology describing the main modifications induced by the interactions between the zeolite and the binder. Additionally, a strategy is presented to overcome the diffusion limitations associated to the microporous structure of zeolites, consisting in the introduction of hierarchical porosity in the binder. Several developments in the field of hierarchical aluminas are summarized in this article, highlighting the possibility to design different ordered/disordered mesoporous and macroporous structures.
Modeling Confined Cell Migration Mediated by Cytoskeleton Dynamics
Authors: Sánchez María Teresa , García-Aznar José Manuel
Published: April 2018

Cell migration is an important biological process that has generated increasing interest during the last several years. This process is based on three phases: protrusion at the front end of the cell, de-adhesion at the rear end and contraction of the cell body, all of them coordinated due to the polymerization/depolymerization of certain cytoskeletal proteins. The aim of this work is to present a mathematical model to simulate the actin polymerization/depolymerization process that regulates the final outcome of cell migration process, considering all the above phases, in a particular case: when the cell is confined in a microfluidic channel. Under these specific conditions, cell migration can be approximated by using one-dimensional simulations. We will propose a system of reaction–diffusion equations to simulate the behavior of the cytoskeletal proteins responsible for protrusion and contraction in the cell, coupled with the mechanical response of the cell, computing its deformations and stresses. Furthermore, a numerical procedure is presented in order to simulate the whole process in a moving and deformable domain corresponding to the cell body.
Optimal Capacity Estimation Method of the Energy Storage Mounted on a Wireless Railway Train for Energy-Sustainable Transportation
Authors: Kim Jaewon , Kim Joorak , Lee Changmu , Kim Gildong , Lee Hansang , Lee Byongjun
Published: April 2018

Although electric railway systems have gone through many technological innovations in their electrical, mechanical and structural engineering since the energy paradigm conversion to electrical energy, the conventional feeding system based on the catenary contact is still being applied. In order to solve the problems of the contact-based feeding system that arise and to build up the energy-sustainable electric railway system simultaneously, this paper considers the wireless railway train (WRT), which is fed by storages mounted on the board without catenary contact during driving and charged at a platform during a stop. In order to maximize the energy improvement of WRTs’ operation, the optimal power and storage capacity estimation method considering the increased weight of the additional storage devices is proposed. Through case studies of the electrical and topographical conditions of the actual operating railway route, compared with the electrical performance of the existing railway trains, it is verified that the application of WRTs leads to facility capacity margin enlargement through the peak power reduction, and cost-effectiveness improvement through the reduction of catenary loss and driving energy.
Switched-Capacitor-Based High Boost DC-DC Converter
Authors: Tran Van-Thuan , Nguyen Minh-Khai , Choi Youn-Ok , Cho Geum-Bae
Published: April 2018

A non-isolated high boost DC-DC converter topology based on a switched-capacitor (SC) structure is introduced in this paper. By controlling the duty cycle in each period, the voltage gain of the converter is adjusted. The main features of the proposed SC converter are the continuous input current, achieving high voltage gain with low voltage and current stress on the power components, no use of a high-frequency transformer, and easy to increase the voltage by adding the SC cell. To correct the operating analysis, a 200-W output power prototype was built with the input voltage in the range of [25 V, 50 V] and the output voltage of 200 V. The proposed inverter reaches a maximum efficiency of 93% at the input voltage of 25 V and the output power of 150 W. The simulation and experimental verifications match the analysis.
A Hydropower Biological Evaluation Toolset (HBET) for Characterizing Hydraulic Conditions and Impacts of Hydro-Structures on Fish
Authors: Hou Hongfei , Deng Zhiqun Daniel , Martinez Jayson J. , Fu Tao , Duncan Joanne P. , Johnson Gary E. , Lu Jun , Skalski John R. , Townsend Richard L. , Tan Li
Published: April 2018

Approximately 16% of the world’s electricity and over 80% of the world’s renewable electricity is generated from hydropower resources, and there is potential for developing significantly more new hydropower capacity. In practice, however, optimizing the use of potential hydropower resources is limited by various factors, including environmental effects and related mitigation requirements. That is why hydropower regulatory requirements frequently call for targets to be met regarding fish injury and mortality rates. The sensor fish (SF) is a small autonomous sensor package that can be deployed through complex hydraulic structures, such as a turbine or spillway, to collect high resolution measurements that describe the forces and motions that live fish would encounter. The Hydropower Biological Evaluation Toolset (HBET), an integrated suite of science-based tools, is designed to use the SF (implemented) and other tools (to be implemented in the future) to characterize the hydraulic conditions of hydropower structures and provide quantitative estimates of fish injury and mortality rates resulting from exposure to various physical stressors including strike, pressure, and shear. HBET enables users to design new studies, analyze data, perform statistical analyses, and evaluate biological responses. It can be used by researchers, turbine designers, hydropower operators, and regulators to design and operate hydropower systems that minimize ecological impacts in a cost-effective manner. In this paper, we discuss the technical methodologies and algorithms implemented in HBET and describe a case study that illustrates its functionalities.
Economic Model Predictive Control with Nonlinear Constraint Relaxation for the Operational Management of Water Distribution Networks
Authors: Wang Ye , Alamo Teodoro , Puig Vicenç , Cembrano Gabriela
Published: April 2018

This paper presents the application of an economic model predictive control (MPC) for the operational management of water distribution networks (WDNs) with periodic operation and nonlinear constraint relaxation. In addition to minimizing operational costs, the proposed approach aims to reduce the computational load and to improve the implementation efficiency associated with the nonlinear nature of the MPC problem. The behavior of the WDN is characterized by a set of difference-algebraic equations, where the relation of hydraulic pressure/head and flow in interconnected pipes is nonlinear. Specifically, the considered WDN model includes two categories of nonlinear algebraic equations for unidirectional and bidirectional flows in pipes, respectively. In this paper, we propose an iterative algorithm to relax these nonlinear algebraic equations into a set of linear inequality constraints that will be implemented in the economic MPC design, which improves the implementation efficiency and meanwhile optimizes the economic performance. Finally, the proposed strategy is applied to a well-known benchmark of the Richmond WDN. The closed-loop simulation results are shown and the proposed strategy is also compared with a nonlinear economic MPC using several key performance indexes.
Fine Scale Determinants of Soil Litter Fauna on a Mediterranean Mixed Oak Forest Invaded by the Exotic Soil-Borne Pathogen Phytophthora cinnamomi
Authors: Jiménez-Chacón Alejandro , Homet Pablo , Matías Luis , Gómez-Aparicio Lorena , Godoy Oscar
Published: April 2018

There is growing recognition of the importance of soil fauna for modulating nutrient cycling processes such as litter decomposition. However, little is known about the drivers promoting changes in soil fauna abundance on a local scale. We explored this gap of knowledge in a mixed oak forest of Southern Spain, which is under decline due to the invasion of the exotic soil-borne pathogen Phytophthora cinnamomi. Meso-invertebrate abundance found in soil litter was estimated at the suborder level. We then explored their statistical correlations with respect to light availability, tree and litter characteristics, and P. cinnamomi abundance. Oribatida and Entomobryomporpha were the most abundant groups of Acari and Collembola, respectively. According to their trophic level, predator and detritivore abundances were positively correlated while detritivores were, in turn, positively correlated with pathogen abundance and negatively influenced by light availability and tree defoliation. These overall trends differed between groups. Among detritivores, Diplopoda preferred highly decomposed litter while Oribatida and Psocoptera preferred darker environments and Poduromorpha were selected for environments with lower tree defoliation. Our results show the predominant role of light availability in influencing litter fauna abundances at local scales and suggest that the invasive soil-borne pathogen P. cinnamomi is integrated in these complex relationships.
Red Blood Cell Agglutination for Blood Typing Within Passive Microfluidic Biochips
Authors: Huet Maxime , Cubizolles Myriam , Buhot Arnaud
Published: April 2018

Pre-transfusion bedside compatibility test is mandatory to check that the donor and the recipient present compatible groups before any transfusion is performed. Although blood typing devices are present on the market, they still suffer from various drawbacks, like results that are based on naked-eye observation or difficulties in blood handling and process automation. In this study, we addressed the development of a red blood cells (RBC) agglutination assay for point-of-care blood typing. An injection molded microfluidic chip that is designed to enhance capillary flow contained anti-A or anti-B dried reagents inside its microchannel. The only blood handling step in the assay protocol consisted in the deposit of a blood drop at the tip of the biochip, and imaging was then achieved. The embedded reagents were able to trigger RBC agglutination in situ, allowing for us to monitor in real time the whole process. An image processing algorithm was developed on diluted bloods to compute real-time agglutination indicator and was further validated on undiluted blood. Through this proof of concept, we achieved efficient, automated, real time, and quantitative measurement of agglutination inside a passive biochip for blood typing which could be further generalized to blood biomarker detection and quantification.
Exercise Caution: Questions to Ask Adolescents Who May Exercise Too Hard
Authors: Forsén Mantilla Emma , Levallius Johanna , Monell Elin , Birgegård Andreas
Published: April 2018

When the primary goal of exercise is to compensate for food intake and to alter body shape and weight, it is considered compulsive and may be harmful. Compulsive exercise (CE) is important in the pathogenesis of eating disorders (EDs). Many healthy adolescents engage in CE too, and this may indicate a risk for EDs. Our aim was to learn more about ED risk factors tied to CE and to try to isolate questions to ask in order to probe for high ED risk in adolescents engaging in CE. Using two well-established instruments (the Structural Analysis of Social Behavior and the Eating Disorders Examination Questionnaire), we studied associations between ED variables and CE in healthy adolescent boys and girls. We examined gender-specific items to generate the best possible fit for each gender. Individuals with CE displayed significantly greater ED pathology and more self-criticism, and this pattern was stronger in girls than in boys. Risk factors for ED among individuals with CE differed slightly for boys and girls. We put forward a set of gender-specific questions that may be helpful when probing for ED risk among adolescents engaging in CE.
CD9 and CD81 Interactions and Their Structural Modelling in Sperm Prior to Fertilization
Authors: Frolikova Michaela , Manaskova-Postlerova Pavla , Cerny Jiri , Jankovicova Jana , Simonik Ondrej , Pohlova Alzbeta , Secova Petra , Antalikova Jana , Dvorakova-Hortova Katerina
Published: April 2018

Proteins CD9 and CD81 are members of the tetraspanin superfamily and were detected in mammalian sperm, where they are suspected to form an active tetraspanin web and to participate in sperm–egg membrane fusion. The importance of these two proteins during the early stages of fertilization is supported by the complete sterility of CD9/CD81 double null female mice. In this study, the putative mechanism of CD9/CD81 involvement in tetraspanin web formation in sperm and its activity prior to fertilization was addressed. Confocal microscopy and colocalization assay was used to determine a mutual CD9/CD81 localization visualised in detail by super-resolution microscopy, and their interaction was address by co-immunoprecipitation. The species-specific traits in CD9 and CD81 distribution during sperm maturation were compared between mice and humans. A mutual position of CD9/CD81 is shown in human spermatozoa in the acrosomal cap, however in mice, CD9 and CD81 occupy a distinct area. During the acrosome reaction in human sperm, only CD9 is relocated, compared to the relocation of both proteins in mice. The structural modelling of CD9 and CD81 homologous and possibly heterologous network formation was used to propose their lateral Cis as well as Trans interactions within the sperm membrane and during sperm–egg membrane fusion.
PIN7 Auxin Carrier Has a Preferential Role in Terminating Radial Root Expansion in Arabidopsis thaliana
Authors: Ruiz Rosquete Michel , Waidmann Sascha , Kleine-Vehn Jürgen
Published: April 2018

Directional growth of lateral roots is critical for radial expansion and soil coverage. Despite its importance, almost nothing is known about its molecular determinants. Initially, young lateral roots (LRs) grow away from the parental root, maintaining the angle acquired shortly after emergence. A second downwards bending response to gravity terminates the so-called plateau phase and thereby limits radial root expansion. Here, we show that the exit from the plateau phase correlates with an increase in auxin signalling at the tip of the LRs. Moreover, the increase in auxin levels induces the termination of the plateau phase, which requires PIN-FORMED (PIN) auxin efflux carriers. Our data suggests that the developmental increase in auxin triggers the preferential derepression of PIN7 in gravity-sensing columella cells. The subsequent polarization of PIN7 heralds the bending towards gravity and, hence, the exit from the plateau phase. This developmental framework reveals the distinct roles of PIN auxin efflux carriers in controlling the radial growth of root systems.
Telomerase Inhibition by a New Synthetic Derivative of the Aporphine Alkaloid Boldine
Authors: Kazemi Noureini Sakineh , Kheirabadi Mitra , Masoumi Fatima , Khosrogerdi Farve , Zarei Younes , Suárez-Rozas Cristian , Salas-Norambuena Julio , Kennedy Cassels Bruce
Published: April 2018

Telomerase, the enzyme responsible for cell immortality, is an important target in anti-cancer drug discovery. Boldine, an abundant aporphine alkaloid of Peumus boldus, is known to inhibit telomerase at non-toxic concentrations. Cytotoxicity of N-benzylsecoboldine hydrochloride (BSB), a synthetic derivative of boldine, was determined using the MTT method in MCF7 and MDA-MB231 cells. Aliquots of cell lysates were incubated with various concentrations of BSB in qTRAP (quantitative telomere repeat amplification protocol)-ligand experiments before substrate elongation by telomerase or amplification by hot-start Taq polymerase. The crystal structure of TERT, the catalytic subunit of telomerase from Tribolium castaneum, was used for docking and molecular dynamics analysis. The qTRAP-ligand data gave an IC50 value of about 0.17 ± 0.1 µM for BSB, roughly 400 times stronger than boldine, while the LD50 in the cytotoxicity assays were 12.5 and 21.88 µM, respectively, in cells treated for 48 h. Although both compounds interacted well with the active site, MD analysis suggests a second binding site with which BSB interacts via two hydrogen bonds, much more strongly than boldine. Theoretical analyses also evaluated the IC50 for BSB as submicromolar. BSB, with greater hydrophobicity and flexibility than boldine, represents a promising structure to inhibit telomerase at non-toxic concentrations.
4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H3 Receptor Antagonist: Further Structure–Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation
Authors: Olszewska Beata , Stasiak Anna , McNaught Flores Daniel , Fogel Wiesława Agnieszka , Leurs Rob , Walczyński Krzysztof
Published: April 2018

Presynaptic histamine H3 receptors (H3R) act as auto- or heteroreceptors controlling, respectively, the release of histamine and of other neurotransmitters in the central nervous system (CNS). The extracellular levels of several neurotransmitters are enhanced by H3R antagonists, and there is a great interest for potent, brain-penetrating H3 receptor antagonists/inverse agonists to compensate for the neurotransmitter deficits present in various neurological disorders. We have shown that 1-[(benzylfuran-2-yl)methyl]piperidinyl-4-oxyl- and benzyl- derivatives of N-propylpentan-1-amines exhibit high in vitro potencies toward the guinea pig H3 receptor (jejunum), with pA2 = 8.47 and 7.79, respectively (the reference compound used was thioperamide with pA2 = 8.67). Furthermore, following the replacement of 4-hydroxypiperidine with a 3-(methylamino)propyloxy chain, the pA2 value for the first group decreased, whereas it increased for the second group. Here, we present data on the impact of elongating the aliphatic chain between the nitrogen of 4-hydroxypiperidine or 3-(methylamino)propan-1-ol and the lipophilic residue. Additionally, the most active compound in this series of non-imidazole H3 receptor antagonists/inverse agonists, i.e., ADS-003, was evaluated for its affinity to the recombinant rat and human histamine H3 receptors transiently expressed in HEK-293T cells. It was shown that ADS-003, given parenterally for 5 days, reduced the food intake of rats, as well as changed histamine and noradrenaline concentrations in the rats’ brain in a manner and degree similar to the reference H3 antagonist Ciproxifan.
cGMP Signaling and Vascular Smooth Muscle Cell Plasticity
Authors: Lehners Moritz , Dobrowinski Hyazinth , Feil Susanne , Feil Robert
Published: April 2018

Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of vascular smooth muscle cells (VSMCs), which display remarkable phenotypic plasticity during the development of vascular diseases, such as atherosclerosis. Recent studies have shown that VSMCs contribute to the development of atherosclerotic plaques by clonal expansion and transdifferentiation to macrophage-like cells. VSMCs express a variety of cGMP generators and effectors, including NO-sensitive guanylyl cyclase (NO-GC) and cGMP-dependent protein kinase type I (cGKI), respectively. According to the traditional view, cGMP inhibits VSMC proliferation, but this concept has been challenged by recent findings supporting a stimulatory effect of the NO-cGMP-cGKI axis on VSMC growth. Here, we summarize the relevant studies with a focus on VSMC growth regulation by the NO-cGMP-cGKI pathway in cultured VSMCs and mouse models of atherosclerosis, restenosis, and angiogenesis. We discuss potential reasons for inconsistent results, such as the use of genetic versus pharmacological approaches and primary versus subcultured cells. We also explore how modern methods for cGMP imaging and cell tracking could help to improve our understanding of cGMP’s role in vascular plasticity. We present a revised model proposing that cGMP promotes phenotypic switching of contractile VSMCs to VSMC-derived plaque cells in atherosclerotic lesions. Regulation of vascular remodeling by cGMP is not only an interesting new therapeutic strategy, but could also result in side effects of clinically used cGMP-elevating drugs.
A Tempest in A Ladle: The Debate about the Roles of General and Specific Abilities in Predicting Important Outcomes
Authors: Johnson Wendy
Published: April 2018

The debate about the roles of general and specific abilities in predicting important outcomes is a tempest in a ladle because we cannot measure abilities without also measuring skills. Skills always develop through exposure, are specific rather than general, and are executed using different strategies by different people, thus tapping into varied specific abilities. Relative predictive validities of measurement formats depend on the purpose: the more general and long-term the purpose, the better the more general measure. The more specific and immediate the purpose, the better the closely related specific measure.
Directed Thermal Diffusions through Metamaterial Source Illusion with Homogeneous Natural Media
Authors: Xu Guoqiang , Zhang Haochun , Jin Liang , Jin Yan
Published: April 2018

Owing to the utilization of transformation optics, many significant research and development achievements have expanded the applications of illusion devices into thermal fields. However, most of the current studies on relevant thermal illusions used to reshape the thermal fields are dependent of certain pre-designed geometric profiles with complicated conductivity configurations. In this paper, we propose a methodology for designing a new class of thermal source illusion devices for achieving directed thermal diffusions with natural homogeneous media. The employments of the space rotations in the linear transformation processes allow the directed thermal diffusions to be independent of the geometric profiles, and the utilization of natural homogeneous media improve the feasibility. Four schemes, with fewer types of homogeneous media filling the functional regions, are demonstrated in transient states. The expected performances are observed in each scheme. The related performance are analyzed by comparing the thermal distribution characteristics and the illusion effectiveness on the measured lines. The findings obtained in this paper see applications in the development of directed diffusions with minimal thermal loss, used in novel “multi-beam” thermal generation, thermal lenses, solar receivers, and waveguide.
Application of Multifrequency Bioelectrical Impedance Analysis Method for the Detection of Dehydration Status in Professional Divers
Authors: Sengun Sermin , Uslu Atilla , Aydin Salih
Published: April 2018

Background and Objective. The level of dehydration has been known to be a predisposing factor for the development of decompression sickness in divers. The aim of this study was to determine the level of dehydration in divers who dove with heliox and to determine whether the source of this dehydration was intracellular and/or extracellular by means of multifrequency bioelectrical impedance analysis (MF-BIA). Material and Methods. Eleven male professional divers were enrolled in the study. In order to determine the level of dehydration, MF-BIA was carried out (at 5, 50, and 100 kHz) and capillary hematocrit (Hct) was measured two times: one before diving and the other after leaving the pressure room. Results. When prediving and postdiving parameters were compared, significant increases in the resistance at 5 kHz (P<0.001), 50 kHz, (P<0.001), and 100 kHz (P<0.01) and Hct (P<0.01) were observed after the diving. Similarly, a statistically significant fluid shift was found: total body water, –1.30 L (P<0.001), extracellular water, –0.85 L (P<0.001); and intracellular water, –0.45 L (P=0.011). Conclusions. Our results showed that mild dehydration occurred both in the intracellular and extracellular compartments in divers after deep diving. This study also indicates that MF-BIA could be a reliable new method for determining the dehydration status in divers.
Mitochondrial Membrane Barrier Function as a Target of Hyperthermia
Authors: Naučienė Zita , Žūkienė Rasa , Degutytė-Fomins Laima , Mildažienė Vida
Published: April 2018

Background and Objective. Hyperthermia is a promising modality for cancer treatment that urgently requires detailed knowledge on molecular and cellular processes for the rational development of treatment protocols. The thorough study of the response of the inner membrane of heart and liver mitochondria to hyperthermia was performed in order to establish the pattern of the hyperthermia-induced changes in the membrane barrier function. Material and Methods. The isolated mitochondria from rat heart and liver (of both genders) were used for experiments, as well as mitochondria isolated from the perfused male rat liver. Changes in the membrane permeability were evaluated by mitochondrial respiration in state 2 or by estimation of the modular kinetics of the membrane leak. Results. The inner membrane of isolated mitochondria from healthy tissues was found to be an extremely sensitive target of hyperthermia that exerted the response even in the febrile range. More severe hyperthermia compromised the inner mitochondrial membrane function; however, this response was tissue-specific and, to some extent, gender-dependent (for liver mitochondria). The data obtained by direct heating of isolated mitochondria were validated by experiments on the perfused liver. Conclusions. The obtained results imply a crucial importance of the evaluation of the tissue- and gender-specific differences while developing or improving the protocols for hyperthermic treatment or combinatory therapy.
The Effect of Nanoparticles in Rats During Critical Periods of Pregnancy
Authors: Žalgevičienė Violeta , Kulvietis Vytautas , Bulotienė Danutė , Didžiapetrienė Janina , Rotomskis Ričardas
Published: April 2018

Background and Objective. Nanotechnology works with substances at a nanometer scale, and it offers many solutions for biomedicine. Nanoparticles (NPs) have been shown as effective agents for imaging, drug delivery, pathogen detection, etc. However, to date, NP toxicity is poorly known. The aim of our study was to investigate the embryotoxicity and teratogenicity of quantum dots (QDs) at the different stages of rat embryogenesis. Materials and Methods. Wistar rats were injected with CdSe/ZnS or CdTe QDs on the 6th, 13th, and 18th days of embryogenesis. Cyclophosphamide was chosen as a positive control of embryotoxicity. On the 21st day, the number of resorptions, weight, length, and external malformations of the embryos were estimated. Fluorescence spectroscopy and microscopy analysis were used to determine the accumulation of QDs in the tissues. Results. Exposure to cyclophosphamide during the pregnancy decreased the embryonic weight and length when compared with the control group and produced numerous malformations. The effects depended on the stage of embryogenesis. Meanwhile, QDs did not cause any embryotoxic or teratogenic effects. However, CdTe QDs induced necrosis in the tissues of the peritoneal cavity. The necrotic tissues contained QDs with altered spectroscopic properties. Spectroscopic and microscopic tissue examination revealed that QDs accumulated in the placenta, but no penetration to the embryonic tissues was observed. Conclusions. QDs did not cause any direct embryotoxic or teratogenic effects, but they had adverse effects on the maternal organism. The observed QD effects and the long-term accumulation of QDs in the maternal organism may increase the risk of adverse effects on embryo development.
Dependence of Perceived Purity of a Chromatic Stimulus on Saturation Adaptation
Authors: Karitans Varis , Ozolinsh Maris
Published: April 2018

Background and Objective. The purpose of sensory adaptation of the visual system is to adjust sensitivity of the photoreceptors to optimize the dynamic range of response of the visual system. It has been shown in numerous research papers that chromatic adaptation influences both color appearance and color discrimination. However, there are almost no studies in which the influence of chromatic adaptation on perceived purity has been investigated. Therefore, the aim of this study was to investigate how chromatic adaptation to stimuli with certain saturation influences perceived purity of test stimuli with the same hue but different saturation. Material and Methods. As the stimuli were modulated in saturation only, we refer to the type of chromatic adaptation used in our study as saturation adaptation. Two types of psychophysical methods – the method of adjustment and the method of constant stimuli – were used. Results. The results obtained with the method of constant stimuli reveal that saturation adaptation seems to be nonlinear much the same way as the Bezold-Brücke and the Abney effect. In addition, hysteresis of saturation adaptation can be observed in the method of adjustment. Conclusions. Pronounced hysteresis of perceived color purity was observed when approaching to the point of subjective equality from the side of low saturation of the matching stimulus compared with the side of high saturation of the matching stimulus. There was a time course of mechanisms of saturation adaptation similar to those of chromatic adaptation previously quoted in literature.
Evaluation of Factors Associated with Hypermetabolism and Hypometabolism in Critically Ill AKI Patients
Authors: Góes Cassiana R. de , Balbi André Luis , Ponce Daniela
Published: April 2018

Acute kidney injury (AKI) is a frequent and serious condition with high mortality. The presence of hypermetabolism may be a factor related to poorer prognosis. This study evaluated the resting energy expenditure (REE) of intensive care unit (ICU) patients with severe AKI using indirect calorimetry (IC) and identified factors associated with metabolism categories. Patients were evaluated through measurement of REE and estimation of basal energy expenditure (BEE) using the Harris–Benedict equation. Metabolism categories were as follows: hypermetabolism (REE/BEE > 1.3) and hypometabolism (REE/BEE < 0.9). The metabolism categories were compared using ANOVA and the chi-square test. Variables were analyzed by multiple logistic regression tests. Also, survivors and non-survivors were compared using Student’s t-tests along with Cox regression tests. Kaplan–Meier survival curves were also performed. We evaluated 124 patients with a mean age of 61.08 ± 16.6 years. Sixty-four patients were hypermetabolic (62%) and 18 were hypometabolic (14%). Vasoactive drug (VAD) dose and younger age were independently associated with hypermetabolism. The survival analysis was not associated with metabolism categorization. In conclusion, patients with severe AKI are mostly hypermetabolic and hypermetabolic patients of a lower age receiving treatment with higher VAD doses. The only factors associated with death were protein intake and VAD dose.
Enhancing Whole Phage Therapy and Their Derived Antimicrobial Enzymes through Complex Formulation
Authors: Cooper Callum J. , Koonjan Shazeeda , Nilsson Anders S.
Published: April 2018

The resurgence of research into phage biology and therapy is, in part, due to the increasing need for novel agents to treat multidrug-resistant infections. Despite a long clinical history in Eastern Europe and initial success within the food industry, commercialized phage products have yet to enter other sectors. This relative lack of success is, in part, due to the inherent biological limitations of whole phages. These include (but are not limited to) reaching target sites at sufficiently high concentrations to establish an infection which produces enough progeny phages to reduce the bacterial population in a clinically meaningful manner and the limited host range of some phages. Conversely, parallels can be drawn between antimicrobial enzymes derived from phages and conventional antibiotics. In the current article the biological limitations of whole phage-based therapeutics and their derived antimicrobial enzymes will be discussed. In addition, the ability of more complex formulations to address these issues, in the context of medical and non-medical applications, will also be included.
Managing Complexity: Exploring Decision Making on Medication by Young Adults with ADHD
Authors: Druedahl Louise C. , Kälvemark Sporrong Sofia
Published: April 2018

Attention-deficit hyperactivity disorder (ADHD) causes difficulties with hyperactivity, impulsivity and inattention. Treatment of ADHD includes both medication and non-pharmacological options. Knowledge of treatment preferences by young adults with ADHD is sparse. The objective of this study was to explore the beliefs and experiences of young adults with ADHD related to their medication treatment decisions. Data were collected in Denmark in 2016 through a focus group and individual in-depth interviews. Conventional content analysis was used. Ten young adults with ADHD (22-to 29-year-old) participated. Three major themes were identified: (1) the patient’s right to choose concerning ADHD medicine; (2) the patient’s decision of whether or not to treat ADHD with medication; and (3) factors affecting the patient’s decision on whether to take ADHD medication or not. The latter theme contained 15 factors, which were distributed across three levels: individual, between-individuals, and societal. The dominant factors were increasing quality of life and improving oneself e.g., improving social skills. For counselling at the pharmacy and by prescribers, it is important to be aware of the different factors that affect young adult patients’ decisions on whether to take ADHD medication or not. This knowledge will aid to understand reasons for non-adherence and to determine appropriate treatment for the individual patient.
Thermal Dependence of Optical Parameters of Thin Polythiophene Films Blended with PCBM
Authors: Jaglarz Janusz , Małek Anna , Sanetra Jerzy
Published: April 2018

The main purpose of this work is to show the thermal dependence of the refractive and extinction indices of conjugated polymer films used in optoelectronics devices. Herein, we present the results of optical investigations performed for the following polymers: poly(3-hexylthiophene) (P3HT), poly(3-octylthiophene) (P3OT), and their blends with [6,6]-phenyl C61 butyric acid methyl ester (PCBM). For our analysis, we chose well-known polythiophenes such P3HT and P3OT, often used in photovoltaic cells. Our addition of PCMB to the polythiophenes allows their conversion efficiency to be increased. This paper presents the results of our investigation determining the spectral dispersion of optical constants in a wavelength range of 190–1700 nm by using spectroscopic ellipsometry (SE). Furthermore, we show the temperature dependence of the refractive indices of polythiophene films for a heating and a cooling process in the temperature range 25–130 °C. Additionally, thermo-optic coefficients and an optical gap were established and are presented in the paper, followed by a discussion on the conditions of the thermal stability of polythiophene blends and reversibility issues in thermal processes. Our paper presents a new and fresh analysis of depolarization beams after their reflection from the studied films. The paper presents the results of thermo-optical studies of polymer blends which have not been included in previously published works.
Experimental Investigation of the Mechanical Behaviors of Grouted Sand with UF-OA Grouts
Authors: Jin Yuhao , Han Lijun , Meng Qingbin , Ma Dan , Han Guansheng , Gao Furong , Wang Shuai
Published: April 2018

A detailed understanding of the engineering properties for grouted sand is a key concern in foundation engineering projects containing sand layers. In this research, experiments of grouting with various grain sizes of sand specimens using a new type of improved chemical material-urea formaldehyde resin mixed with oxalate curing agent (UF-OA), which has rarely been used as grout in the reinforcement of soft foundations, were conducted on the basis of a self-developed grouting test system. After grouting tests, the effects on the mechanical behaviors of grouted sand specimens were investigated through uniaxial compression tests considering the grain size, the presence or absence of initial water in sand, and the curing time for grouted sand. Experimental results show that with the increase in the grain size and the presence of initial water in the sand specimen, the values of uniaxial compressive strength (UCS) and elastic moduli (E) of the grouted specimens decreased obviously, indicating that the increase of grain size and the presence of initial water have negative impacts on the mechanical behaviors of grouted sand; the peak strains (εc) were almost unchanged after 14 days of curing; no brittle failure behavior occurred in the grouted specimens, and desirable ductile failure characteristics were distinct after uniaxial compression. These mechanical behaviors were significantly improved after 14 days of curing. The micro-structural properties obtained by scanning electron microscopy (SEM) of the finer grouted sand indicate preferable filling performance to some extent, thereby validating the macroscopic mechanical behaviors.
Icing Detection over East Asia from Geostationary Satellite Data Using Machine Learning Approaches
Authors: Sim Seongmun , Im Jungho , Park Sumin , Park Haemi , Ahn Myoung , Chan Pak-wai
Published: April 2018

Even though deicing or airframe coating technologies continue to develop, aircraft icing is still one of the critical threats to aviation. While the detection of potential icing clouds has been conducted using geostationary satellite data in the US and Europe, there is not yet a robust model that detects potential icing areas in East Asia. In this study, we proposed machine-learning-based icing detection models using data from two geostationary satellites—the Communication, Ocean, and Meteorological Satellite (COMS) Meteorological Imager (MI) and the Himawari-8 Advanced Himawari Imager (AHI)—over Northeast Asia. Two machine learning techniques—random forest (RF) and multinomial log-linear (MLL) models—were evaluated with quality-controlled pilot reports (PIREPs) as the reference data. The machine-learning-based models were compared to the existing models through five-fold cross-validation. The RF model for COMS MI produced the best performance, resulting in a mean probability of detection (POD) of 81.8%, a mean overall accuracy (OA) of 82.1%, and mean true skill statistics (TSS) of 64.0%. One of the existing models, flight icing threat (FIT), produced relatively poor performance, providing a mean POD of 36.4%, a mean OA of 61.0, and a mean TSS of 9.7%. The Himawari-8 based models also produced performance comparable to the COMS models. However, it should be noted that very limited PIREP reference data were available especially for the Himawari-8 models, which requires further evaluation in the future with more reference data. The spatio-temporal patterns of the icing areas detected using the developed models were also visually examined using time-series satellite data.
Woody Cover Estimates in Oklahoma and Texas Using a Multi-Sensor Calibration and Validation Approach
Authors: Hartfield Kyle A. , Van Leeuwen Willem J. D.
Published: April 2018

Woody cover encroachment/expansion/conversion is a complex phenomenon that has environmental and economic impacts around the world. This research demonstrates the development of highly accurate models for estimating percent woody cover using high spatial resolution image data in combination with multi-seasonal Landsat reflectance products. We use a classification and regression tree (CART) approach to classify woody cover using fine resolution multispectral National Agricultural Imaging Program (NAIP) data. A continuous classification and regression tree (Cubist) ingests the aggregated woody cover classification along with the seasonal Landsat data to create a continuous woody cover model. We applied the models, derived by Cubist, across several Landsat scenes to estimate the percentage of woody plant cover, within each Landsat pixel, over a larger regional extent. We measured an average absolute error of 12.1 percent and a correlation coefficient of 0.78 for the models performed. The method of modelling percent woody cover established in this manuscript outperforms currently available woody cover estimates including Landsat Vegetation Continuous Fields (VCF), on average by 26 percent, and Web-Enabled Landsat Data (WELD) products, on average by 16 percent, for the region of interest. Current woody cover products are also limited to certain years and not available pre-2000. This manuscript describes a novel Cubist-based technique to model woody cover for any area of the world, as long as fine (~1–2 m) spatial resolution and Landsat data are available.