bluuebunny/crossref_metadata_2025 huggingface dataset:
La crisi separativa e il sistema legale: procedure in alternative dispute resolution e interdisciplinarietà
Authors: Petrolo Marina
Published: March 2021

L'articolo focalizza il diritto o la pratica collaborativa come uno dei più significativi strumenti di risoluzione alternativa del contenzioso familiare che giunge a valle di un profondo mutamento culturale. I professionisti collaborativi non sono soltanto avvocati, ma anche commercialisti, mediatori familiari, psicologi che si impegnano per offrire ai cittadini un approccio non contenzioso, riservato e rispettoso della dignità dei soggetti coinvolti per la gestione delle questioni attinenti la loro separazione e/o divorzio, l'affidamento dei bambini, la revisione degli accordi e le altre questioni di diritto di famiglia, utilizzando il "diritto (definibile anche metodo) collaborativo". Oltre l'esito deflattivo del contenzioso, il metodo collaborativo presenta altresì aspetti di indubbia utilità sociale. L'articolo, dopo una descrizione della storia del diritto collaborativo, presenta i principi e le procedure che guidano i professionisti che aderiscono alla sua pratica.
Diversity of beetles associated with watermelon crops Citrullus lanatus (Thunb.) Mats. in the region of Ouargla (southern Algeria)
Authors: Kacha D. , Guezoul O. , Marniche F. , Viñolas A.
Published: March 2021

We studied the diversity of beetle families in watermelon fields in the palm grove of Zaatote at Ouargla (34º 54′ N, 5º 20′ E). The sampling method used was Barber pots as they allowed the largest number of captures of insects, regarding both individuals and species. Over the three years of the study (2016, 2017 and 2018), we identified 787 individuals from 12 taxonomic families. Throughout the sampling period, the Coccinellidae family was clearly dominant, with an Fc = 35.02 % in 2016, 36.2 % in 2017 and 34.34 % in 2018. The second most dominant family was Tenebrionidae with an Fc = 26.35 % in 2016, 30.04 % in 2017, and 33.33 % in 2018. Other families were poorly represented. In 2016, regarding their trophism, 18 species of beetles (30.91 %) were phytophagous and feed on the watermelon crop, while 26 species were predatory and decomposing auxiliaries.

Data published through GBIF (Doi: 10.15470/sfhxty)
“PARA NUNCA ESQUECER”
Authors: Dionisio da Silva Tiago , Sacramento de Sousa Nilcelio , Carvalho Rodrigues Adenir
Published: March 2021

Discutir a questão dos direitos humanos no atual contexto é tarefa urgente que se impõe à escola, espaçotempo que, ao mesmo tempo em que materializa problemas existentes na sociedade, tem a possibilidade de contextualizá-los, construir críticas e mudanças sociais. Esse artigo se propõe a refletir sobre uma experiência de educação em Direitos Humanos vivenciada em uma escola estadual localizada na Baixada Fluminense. A experiência originou-se de iniciativa da Secretaria de Estado de Educação do Rio de Janeiro (SEEDUC/RJ) para toda rede estadual e materializou-se em um processo de construção de autonomia tanto da escola, que elaborou sua proposta, quanto dos(as) estudantes, que participaram de todo o processo. Trata-se, assim, de uma reflexão sobre a potência das oficinas pedagógicas realizadas a partir de eixos ancorados no cotidiano da escola e negociados com os(as) estudantes. A experiência com as oficinas pedagógicas possibilitou a construção de tessituras de reflexões sobre a (re)produção dos estigmas sociais que rebatem no espaço escolar e sobre a urgência de se (re)pensar o currículo escolar na tentativa de desmistificar a naturalização e normatização da negação dos Direitos Humanos, discriminação e preconceitos.
PENGARUH CORPORATE GOVERNANCE DAN KINERJA PERUSAHAAN TERHADAP KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN BAGI PERUSAHAAN GO PUBLIC
Authors: Andarsari Pipit Rosita
Published: March 2021

This study aims to determine the effect of the board of commissioners, audit committees, profitability ratios, leverage ratios, and liquidity ratios on the timely delivery of financial statements. In this study the commissioner variable is proxied by the size of the board members, the audit committee is proxied by the size of the audit committee member, profitability ratio is proxied by ROA, leverage ratio is proxied by DER, and liquidity ratio is proxied by CR. The research sample the basic and chemical sectors listed on the Indonesia Stock Exchange in 2016-2017 using a purposive sampling method. Research data sources secondary. Data analysis techniques logistic regression analysis. The results that the board of commissioners, audit committee, profitability ratio (ROA), and leverage ratio (DER) had no significant effect while the liquidity ratio (CR) had a significant effect on the timeliness of financial statement submission.

Keyword : board of commissioners, audit committee, profitability ratio (ROA), leverage ratio (DER) , leverage ratio (DER)
The Contribution of the Griot Kulba Baaba Seebeeri to Cultural Renaissance in Niger
Authors: Idé Oumarou Adamou
Published: March 2021

This paper is an analysis of the heroic songs of the griot Kulba Baaba from Niger. It aims at contributing to promote culture, especially the Songhay-Zarma one, through cultural Renaissance in Niger. It puts emphasis on the respect of the principles of the constitution by encouraging the Nigerien citizen to have certain moral values such as courage, dignity, and loyalty. Its core focus is to show that oral literature can be one of the means to sensitize the Nigerien citizen to a change of mentality for the well-being of the nation.
Towards a definition of anti-oppressive dietetic practice in Canada
Authors: Ng Eric , Wai Caroline
Published: March 2021

Increasingly, dietitians have found ourselves working with racialized clients, communities, and colleagues across the health and food systems in Canada. We are often asked to treat the adverse health outcomes of Black, Indigenous, and racialized communities resulting from these oppressions at the individual level. However, it is the role of dietitians to engage in efforts to "reduce health inequities and protect human rights; promote fairness and equitable treatment" (College of Dietitians of Ontario, 2019). An anti-oppression approach is required for dietitians to understand how their power and privilege shape the dietitian-client relationship. The purpose of this commentary is to propose a shift from cultural competence or diversity and inclusion in dietetics to an explicit intention of anti-oppressive dietetic practice. We begin our exploration from the Canadian context. We draw from our background working in health equity in public health, and our experiences facilitating equity training using anti-oppression approaches with dietetic learners and other public health practitioners. In creating a working definition of anti-oppressive dietetic practice, we conducted a scan of anti-oppression statements by health and social services organizations in Ontario, Canada, and literature from critical dietetics. A literature search revealed anti-oppressive practice frameworks in nursing and social work. However, this language is lacking in mainstream dietetic practice, with anti-oppression only discussed within the literature on critical dietetics and social justice. We propose that "dietitians can engage in anti-oppressive practice by providing food and nutrition care/planning/service to clients while simultaneously seeking to transform health and social systems towards social justice."
Closer Defining of the Content of the Concept of Bank Marketing in the Context of Digitalization of the Economy
Authors:   Simon Kuznets Kharkiv National University of Economics, Lozynska O. I.
Published: March 2021

The article is aimed at exploring the evolution of scientific approaches to defining the essence of bank marketing, closer defining the content of the concept of bank marketing in the context of digitalization of the economy, determining the essence and place of digital marketing in the general system of bank marketing. As a result of the research, it is found out that the modern scientific conception of bank marketing is digital marketing, which provides grounds to supplement the periodization of the development of bank marketing in Ukraine with a modern stage that corresponds to the introduction of the conception of digital marketing. It is substantiated that digital marketing coexists in the general system of bank marketing with traditional and Internet marketing and applies to traditional and innovative banking products and services. In this context, a differentiation of bank marketing by two features is proposed: type of bank product/service (traditional/innovative) and the type of bank marketing (traditional, informational, digital). In accordance with the suggested differentiation, it is proposed to develop a portfolio of bank marketing strategies. It is proved that the digital marketing strategy is systematically integrated into the overall strategic marketing planning of banking institutions. It is proposed to consider the stages of formation of the digital marketing strategy in connection with the portfolio of marketing strategies implemented in the bank’s activities. Prospects for further research are the scientific substantiation of strategic, tactical and operational aspects of digital marketing in order to increase its efficiency and effectiveness in promoting the image of the bank, banking services and products, attracting and retaining consumers of financial services.
Estimating the Marketing Potential of Enterprise and Substantiating the Measures for Its Increase
Authors:   Simon Kuznets Kharkiv National University of Economics, Ponomarenko O. O. , Pyvavar I. V. ,   Simon Kuznets Kharkiv National University of Economics, Lisna I. F. ,   Simon Kuznets Kharkiv National University of Economics
Published: March 2021

The article estimates the marketing potential of enterprise and substantiates the measures to increase it. The economic potential of marketing activity is the final economic result of the introduction of relevant marketing measures, derived from achieving a positive result from the implementation of marketing solutions at optimal costs in therms of both material and financial funds, taking into account the accomplishment of planned tasks. The deployment of processes of international economic integration in the course of globalization of the system of world economic relations causes the inter-penetrating of individual national economies, coordination of government actions in the development of economic policy that corresponds to the interests of all parties involved in the integration process, also with regard to third countries. Integration is ensured by the concentration and intertwining of various capital. Integration processes are rational in nature, gaining the form of associations aimed at achieving the overall economic targets of the participants. Competitive advantages arise as a result of rivalry in the projecting, production, sale and operation of products. Their formation is seriously influenced by the competitive environment: potential and current competitors, consumers of products and suppliers, manufacturers of substitute goods, as well as the State regulation. Under these conditions, the formation of competitive advantages is transformed into the task of active adaptation of the enterprise management system to changes in the competitive environment. Although, real positive results are achieved where this work is brought to the level of management technologies.
Імплементація інформаційних технологій в контексті функціональної розбудови системи управління митними ризиками
Authors: Брендак А. І.
Published: March 2021

У статті актуалізовано питання подальшого розвитку системи управління митними ризиками, а саме зазначено, що комплексна система управління ризиками має покривати усі етапи процесу управління ризиками та передбачати можливість простеження процесу розробки кожного інструменту з управління ризиками. Автором запропоновано передбачити у базі даних профілів ризику календар зі сповіщеннями, які повідомлятимуть посадовій особі відповідального за контроль ефективності профіля ризику підрозділу про необхідність проведення аналізу роботи профіля ризику (ризик-правила). Крім того, зазначено, що комплексне ІТ-рішення в частині функціонування АСУР має передбачати не лише ведення обліку профілів ризику (створення, оновлення, деактивація), а такожвключати компоненти для проведення тестування профілів ризику та здійснення онлайн моніторингу ефективності їх роботи. З метою забезпечення належної роботи профілів ризику АСУР відповідне ІТ-рішення має передбачати можливість інтеграції з шиною обміну даними та іншими інформаційними системами через API-з’єднання (Application Programming Interface) та бути інтегрованим до BI-системи, що включає відображення BI-віджетів з ключовими показниками ефективності профіля ризику (наприклад, селективність, результативність, ефективність профіля ризику, частка компаній, які потрапили під його дію та мають статус добропорядного суб’єкта господарювання).
Spices addition as strategy for polyphenol increase in baked product
Authors: Silva Daiana Freitas da , Faller Ana Luisa Kremer
Published: March 2021

Spices are a rich source of polyphenols and when consumed regularly in the diet contribute to the beneficial health effects of these bioactive compounds. The aim of this study was to elaborate a baked product, honeybreads, without spices, control honeybread (CHB) and with ) the addition of spices, spiced honeybread (SHB, estimate their polyphenol content and evaluate their sensory acceptance. The macronutrient composition was calculated using the Brazilian Food Composition Database and phenolic compounds content calculated based on Phenol-Explorer 3.0 database. For sensory evaluation, a consumer panel was established, and a seven-point structured hedonic scale applied for: aroma, texture, appearance, taste and total acceptance. Each formulation yielded seventy 16g servings with similar calories. The total phenolic compound content, per serving, of SHB was 11,198mg and for CHB 9,483mg, content approximately 18% higher with the addition of spices. Both formulations showed good acceptability based on the acceptability index with over 75% on every parameter. Selection of specific ingredients can positively impact polyphenol content in baked products without compromising sensory characteristics.
Ácido ascórbico e pigmentos fotossintéticos na alface crespa cultivada em sistema hidropônico com soluções salinas
Authors: Xavier Josilda de França , Azevedo Carlos Alberto Vieira de , Azevedo Márcia Rejane de Q. Almeida , Sales Julio Cesar Rodrigues de , Fernandes Josely Dantas , Corrêa Elida Barbosa
Published: March 2021

O objetivo desta pesquisa foi determinar os teores de clorofila e vitamina-C nas cultivares da alface (Elba, Cristina e Veneranda) cultivadas em sistema hidropônico com soluções nutritivas apresentando diferentes níveis de salinidade. O experimento foi conduzido na Universidade Estadual da Paraíba,UEPB Campus-II, zona rural da cidade de Lagoa Seca-PB, via técnica Fluxo Laminar de Nutrientes-NFT em ambiente protegido. O delineamento experimental foi em blocos casualizados, em esquema de parcelas subdivididas, as parcelas constituídas por sete soluções nutritivas preparadas a partir da metodologia de Furlani de modo que a solução S1 apresentou Condutividade Elétrica-CE (1,9 dS m-1) e as demais soluções os seguintes valores de CE: S2-2,4; S3-2,9; S4-3,4; S5-3,9; S6-4,4 e S7-4,9 dS m-1, com três repetições. As subparcelas foram compostas pelas cultivares Elba, Cristina e Veneranda. As variáveis analisadas foram: teores de clorofila (Chl a e b) total, carotenoides e vitamina-C. As soluções nutritivas apresentaram comportamento linear para todos os tratamentos não deferindo estaticamente entre si. O maior valor para clorofila total foi obtido na cultivar Veneranda. Para as variáveis (Chl b e total) os maiores teores encontrados foi na cultivar Veneranda, cujos valores foram de 35,97 e 52,06 mg/g-1 respectivamente. O tratamento Elba/S3=3,4 dS m-1 proporcionou o maior teor de carotenoides média de 57 mg/g-1, ainda a cultivar Elba apresentou os maiores teores (Chl a) com as soluções nutritivas S2=2,4 e S3=3,9 dS m-1. A cultivar Veneranda promoveu os maiores teores para (Chl b e total). Os maiores teores de vitamina-C foram encontrados nas cultivares Cristina e Veneranda.
Clinical and systemic management of myiasis in a patient with advanced Alzheimer's disease
Authors: Silva William Phillip Pereira da , Barbosa Stéfany , Coelho Mendes Bruno , Diego Pavelski Mateus , Santos Anderson Maikon de Souza , Silva Mirela Caroline , Santos João Matheus Fonseca e , Magro Filho Osvaldo , Faverani Leonardo Perez
Published: March 2021

The management of patients with neurodegenerative conditions such as Alzheimer's disease presents a challenge in promoting oral health, which is mainly linked to the motor and cognitive limitations that these individuals have, making them susceptible to the development of a series of oral diseases, such as oral myiasis. The presence of larvae in the oral cavity in patients with Alzheimer's disease seems to be related to poor oral hygiene condition, to the long periods that the patient remains immobile and with the mouth ajar, facilitating the deposition of eggs. Therefore, this study aimed to report a clinical experience of a patient with Alzheimer's disease in an advanced stage and with manifestation of oral myiasis on the oral floor, vestibule bottom and inserted gum. The 81-year-old patient was debilitated, bedridden, unable to perform his activities alone, was taken to the emergency room by his caregiver, who reported having noticed the presence of larvae in the oral cavity. The patient was hospitalized and immediately administered Ivermectin, ceftriaxone and clindamycin. On the second day of hospitalization, he presented a systemic worsening due to bronchoaspiration, requiring immediate removal of the larvae under local anesthesia. Only after significant improvement in the general condition, thorough surgery was performed to debridement of the injured areas and remnants of larvae. After hospital discharge with 2-month follow-up, the patient did not have any complications related to his oral health, demonstrating that periodic follow-up to debilitated patients is an important tool for preventing opportunistic manifestations such as oral myiasis.
Características morfológicas, melhoramento genético e densidade de plantio das culturas do sorgo e do milho: uma revisão
Authors: Silva Davi Francisco da , Garcia Pedro Henrique de Melo , Santos Girlene Cordeiro de Lima , Farias Iasmin Myrele Santos Calaça de , Pádua Guilherme Vinicius Gonçalves de , Pereira Pedro Henrique Borba , Silva Francisco Edson da , Batista Regiane Farias , Gonzaga Neto Severino , Cabral Ana Maria Duarte
Published: March 2021

Nesse estudo, objetivou-se realizar uma breve revisão sobre características morfológicas, melhoramento genético e densidade de plantio das culturas do sorgo (Sorghum bicolor L.) e do milho (Zea mays L.). A busca da literatura incluída no estudo foi conduzida por meio de uma pesquisa eletrônica nas bases de dados Google Scholar, Scientific Electronic Library Online (SciELO), na web e em sites da Empresa Brasileira de Pesquisa Agropecuária – EMBRAPA. Como critério de inclusão, se considerou bibliografias que tratassem de temas relacionados a morfologia, genética e densidades de plantio do milho e do sorgo. Os critérios de exclusão das bibliografias foram:  estudos fora do objetivo do estudo e que não contemplaram o período e idioma estabelecido da pesquisa. De modo geral, o milho e o sorgo são gramíneas que contribuem diretamente com a cadeia produtiva e com o agronegócio, em decorrência da sua importância nutricional em sistemas de produção animal. As suas caraterísticas botânicas, morfológicas e fenológicas, permitem que essas culturas apresentem boa produtividade e adaptabilidade em diferentes regiões do Brasil (Sul, Região Central e Nordeste). A capacidade de adaptação do milho e do sorgo às distintas condições edafoclimáticas, dependem do potencial genético da semente e do sistema de plantio empregado, bem como, da competência do tipo de genótipo em suportar até certo ponto altas densidades populacionais. Sugere-se a condução de estudos que avaliem individualmente os atributos morfológicos e fenológicos de distintas variedades do milho e do sorgo e suas habilidades de adaptação e produção em diferentes densidades de plantio.
Compostos à base de molibdênio para remediação ambiental: uma revisão
Authors: Nascimento Filho Carlos Alves do , Oliveira Helinando Pequeno de
Published: March 2021

O dissulfeto de molibdênio é um material amplamente utilizado para remediação ambiental tendo em vista sua excelente capacidade de adsorção, que é atribuída principalmente aos sítios ativos de enxofre na superfície do MoS2. Além disso, este material possui vantagens quando comparado com outros fotocatalisadores, como por exemplo por alta atividade fotocatalítica, baixa toxicidade e boa capacidade de remoção de contaminantes orgânicos e inorgânicos. Nesta revisão apresentaremos os diferentes métodos de preparação do dissulfeto de molibdênio a partir da esfoliação mecânica, química, eletroquímica e os métodos hidrotérmico, solvotérmico e de deposição de vapor químico. Abordaremos ainda suas propriedades tais como as capacidades de adsorção para diferentes tipos de metais pesados em solução, os tipos de degradação fotocatalítica a partir da comparação dos adsorventes a base de MoS2 com outros adsorventes, os mecanismos de adsorção e os fatores que afetam esse processo, como o pH e temperatura da solução, tempo de contato, tipos de contaminantes e a influência de outros íons presentes em solução que podem atrapalhar o processo de adsorção. Outro processo a ser reportado se refere à associação entre o MoS2 e outros compostos, como óxido de grafeno e compostos derivados do nitrogênio, óxido de titânio e associações com bismuto e prata, tendo como principal vantagem o aumento da capacidade de adsorção do material. Como conclusão, será tratado sobre a eficiência de remoção das diferentes associações do dissulfeto de molibdênio frente aos diferentes tipos de contaminantes assim como os diversos fatores que influenciam nesta eficiência.
Epidemiologia e impacto econômico da ocorrência da brucelose em um município do Estado de Santa Catarina
Authors: Possa Marina Gabriela , Bernardi Fabricio , Pinto Neto Adalgiza , Cattelam Jonatas , Nascif Júnior Iucif Abrão , Trenkel Camila Keterine Gorzelanski , Mota Marcelo Falci
Published: March 2021

A brucelose é uma das mais importantes e negligenciadas doenças zoonóticas. Objetivou-se com o estudo conhecer a epidemiologia, as perdas econômicas e os fatores de risco da brucelose em bovinos, equinos, cães e humanos no município de Flor do Sertão – Santa Catarina. Examinou-se para Brucella abortus, entre 2017 e 2018, 2.750 bovinos, de 131 propriedades; 20 equinos e 29 cães. Os testes sorológicos de triagem seguidos de confirmatório realizados foram o AAT e 2 ME/SAT. Para casos de brucelose humana, a secretaria de saúde do município concedeu 206 resultados sorológicos referentes ao mesmo período de estudo dos bovinos. Foram calculadas prevalências da doença para as populações e utilizado o teste da árvore de decisão, pelo programa estatístico Weka®, para estabelecer associação entre fatores de risco e a positividade de rebanhos. O teste de Spearman (GraphPad Prism®) foi utilizado para estabelecer correlação entre casos humanos e bovinos. 45,5% da população de bovinos do município foi testada, demonstrando prevalência de brucelose de 0,29%. As perdas econômicas anuais foram de R$ 14.747,92. Foram positivos 5,33% dos humanos testados. Os fatores associados com a positividade para a doença baseiam-se no consumo produtos lácteos sem tratamento térmico, e prevalência de brucelose acima de zero. Observou-se que em Flor do Sertão – SC, a prevalência de brucelose em bovinos é baixa, porém, elevada para focos. No entanto, a prevalência da doença em humanos foi elevada, sendo superior a prevalência animal, possivelmente decorrente dos fatores de risco associados a positividade da doença, como o consumo de lácteos crus.
Myocardial phospholipid remodeling under different types of load imposed during early postnatal development
Authors: Novák F , Kolář F , Hamplová B , Mrnka L , Pelouch V , Ošťádal B , Nováková O
Published: March 2021

Normal increase in hemodynamic load during early postnatal life
is associated with heart growth and maturation of membrane
structures that is accompanied by remodeling of membrane
protein and lipid components. This review describes remodeling
of phospholipids (PL) in rat myocardium during normal postnatal
development and during accelerated cardiac growth induced by
additional workload (aorta constriction, chronic hypoxia and
hyperthyroidism) imposed on the heart early after birth. Normal
physiological load after birth stimulates the development of
membrane structures and synthesis of PL. While hyperthyroidism
accelerates these processes, pressure overload has an inhibitory
effect. These changes primarily influence the maturation of
mitochondrial membranes as cardiolipin is one of the most
affected PL species. The most sensitive part of PL structure in
their remodeling process are PL acyl chains, particularly
polyunsaturated fatty acids that are the key components
determining the basic physicochemical properties of the
membrane bilayer and thus the function of membrane-bound
proteins and membrane-derived signaling lipid molecules. It is
evident that PL remodeling may significantly influence both
normal and pathological postnatal development of myocardium.
Antihyperglycemic Activities of Uli Banana Leaves on Oral Sugar Tolerance
Authors: Hendra Phebe , Rizki Nona , Safitri Elin
Published: March 2021

Banana has been widely cultivated. This study aimed to determine the antihyperglycemic activity of Uli banana leaves infusion. The antihyperglycemic activity was evaluated by oral glucose and sucrose tolerance test. A bolus of sugar was given after Uli banana leaves infusion and blood was sampled at 0, 15, 30, 60, 90 and 120 minutes for glucose analyses. The trapezoidal rule was used to determine the area under the curve (AUC) blood glucose. Infusion of Uli banana leaves 3.3 g/kg showed a significant decrease AUC (p<0.05) in the glucose tolerance test, while that of dose 0.8 g/kg reduced significantly (p<0.05) in the sucrose tolerance test. The results showed that Uli banana leaves infusion possesses antihyperglycemic effect in mice.
Antioxidant Activities of Lemongrass with Solvent Multi-Step Extraction Microwave-Assisted Extraction as Natural Food Preservative
Authors: Wuryatmo Erminawati , Suri Anita , Naufalin Rifda
Published: March 2021

The use of synthetic preservatives is considered to have an adverse effect (carcinogenic) upon prolong consumption. Lemongrass (Cymbopogon citratus) is a plant that has bioactive components to act as antioxidants and potential to use as a natural food preservative. Bioactive components can be non-polar, semi-polar and polar; therefore, to determine the dominant bioactive components, a solvent multi-step extraction carried out. This study aimed to determine the specific bioactive components of lemongrass (antioxidant activity, total phenolic content and total flavonoids) suitable of polarity in the leaves and stem of lemongrass extract obtained from solvent multi-step extraction with Microwave-Assisted Extraction. The solvent used is ethanol (polar), ethyl acetate (semi-polar) and n-hexane (non-polar). The result showed that the highest bioactive components obtained from the polar stem lemongrass with total phenolic content of 19.31 mg GAE/g, flavonoids of 3.31 mg GAE/g. This result related to antioxidant activity of the extract of 79.96 %. The high antioxidant activity showed that lemongrass has potential to be used as a natural food preservative, especially in high fat food products.
TINJAUAN KRITIS FENOMENA HABAIB DALAM PANDANGAN MASYARAKAT BETAWI
Authors: Al Fahmi Faiz Fikri
Published: March 2021

Masyarakat Betawi Batu ceper Kota Tangerang memiliki perbedaan dan keunikan dalam menghormati para habib dan kiai, Dimana status habib bagi seseorang dipandangnya mulia, melebihi kemuliaan seorang kiai yang tidak berstatus habib. Masyarakat Betawi Batu Ceper seakan-akan menilai bahwa habib lebih tinggi dari seorang ustadz walau secara keilmuan lebih matang seorang kiai dari pada habib. Tujuan penelitian ini adalah, (1) mengetahui sejarah habib di Betawi, (2) mengetahui peran habib dalam penyebaran Islam di Betawi, (3) mengetahui pola kehidupan beragama masyarakat Betawi, (4) mengetahui pandangan, sikap dan kecenderungan orang Betawi terhadap habaib, dan (5) mengetahui apa penyebab ketokohan habib di kalangan masyarakat Betawi. Penelitian ini menggunakan data-data atau sumber-sumber yang ada hubungannya dengan penelitian tesis ini, data tersebut antara lain meliputi: observasi partisifatif, yaitu dengan mengunjungi tempat penelitian dan sekaligus mengikuti atau berpartisipasi langsung dengan kegiatan-kegiatan majelis taklim yang diselenggarakan untuk mengamati fenomena habaib dalam pandangan masyarakat Betawi. Dan juga sumber lisan dengan cara wawancara dengan tokoh, ulama, dan masyarakat setempat dan selanjutnya menggunakan sumber tertulis melalui dokumen pribadi dan juga buku-buku yang ada hubungannya dengan penelitian ini. Kesimpulan dari penelitian ini yaitu orang Arab di Betawi awalnya bertujuan untuk mencari kemakmuran dengan cara berdagang. Selanjutnya mereka menyebarkan Islam di kalangan masyarakat Betawi. Peran habaib sangat besar pengaruhnya dalam proses Islamisasi di Betawi. Masyarakat Betawi sangat kental akan ajaran Islamnya, mereka umumnya mencintai dan menaru sikap penghormatan yang tinggi terhadap para tokoh agama. mereka mempunyai nilai penghargaan yang tinggi kepada ulama karena kapasitas keilmuannya sangat mumpuni. terlebih ulama yang hadir dari kalangan habib. Karena dianggapnya sebagai tali keturunan yang murni dari sang pembawa ajaran Islam yaitu Nabi Muhammad SAW.
DISKURSUS MEDIASI DAN UPAYA PENYELESAIAN PERDATA ISLAM DI INDONESIA
Authors: Karmawan Karmawan
Published: March 2021

AbstrakMediasi memberikan nilai-nilai budaya dalam masyarakat Indonesia dan menjunjung tinggi nilai-nilai ketimuran yang lebih medahulukan musyawarah mufakat dari pada melalui pengadilan yang akan memberikan kerugian kepada kedua belah pihak dan dapat diimplementasikan dalam mediasi di pengadilan Agama yang lebih efisien dan efektif.Terkait hukum Islam, upaya mendamaikan orang-orang yang bersengketa merupakan perintah Allah SWT dan Rasulullah SAW kepada umat manusia. Hal ini bertujuan agar manusia selalu menghadapi permasalahan dengan kepala dingin dan bukan dengan kekerasan sehingga terciptanya ketentraman dalam kehidupan manusia, khususnya permasalahan yang terjadi dalam rumah tangga. Bahkan prinsip dan nilai damai yang diderivasi dari tradisi ajaran Islam, akan mampu menyelesaikan konflik, baik dalam lapangan sosial maupun politik.
Aplikasi Bacillus sp Pada Produksi Enzim Menggunakan Metode Fermentasi Padat - Review
Authors: Maftukhah Siti
Published: March 2021

Solid State Fermentation (SSF) atau fermentasi padat dianggap sebagai metode fermentasi yang paling menguntungkan dari pada Submerged Fermentation (SmF) atau fermentasi terendam. Hal ini dikarenakan bahwa metode fermentasi padat (SS) lebih ramah lingkungan, produktivitas fermentasi yang lebih tinggi, konsentrasi produk dan stabilitas yang lebih tinggi, penekanan katabolik yang lebih rendah, penanaman mikroorganisme khusus untuk substrat yang tidak larut dan juga aktifitas  sterilitas yang lebih rendah karena aktivitas air yang digunakan sangat rendah. Bacillus sp dapat digunakan untuk produksi enzim. Makalah ini mengulas aplikasi fermentasi padat (SSF) untuk produksi enzim yaitu amilase, esterase, xilanase, pektinase dan  likenase oleh Bacillus sp. Dalam produksi enzim yang menggunakan Bacillus sp adalah Bacillus cereus yang menghasilkan enzim amilase, Bacillus sp. JB-99 yang menghasilkan enzim xilanase, Bacillus licheniformis yang menghasilkan enzim likenase, Bacillus altitudinis AP-MSU  yang menghasilkan enzim esterase, Bacillus sp. DT7 menghasilkan enzim pektinase, dan banyak Bacillus sp dengan proses fermentasi padat yang menghasilkan enzim.
Browning Prevention of Flour from Freshly Harvested Porang (Amorphophallus oncophyllus) Tubers through Immersion in Sodium Metabisulfite at Various Times
Authors: Amyranti Mutia
Published: March 2021

Porang (Amorphophallus oncophillus) tubers contain multifunctional water-soluble heteropolysaccharides, called glucomannan. Therefore, the quality of porang tuber chips is highly depending on its glucomannan content and physical appearance. The presence of considerable amount of carotene, polyphenoloxidases and tannins in these tubers may cause browning of flour during processing. The purpose of this research was to study the effect of enzymatic anti-browning agent (sodium metabisulfite) concentrations (2, 5 and 7.5%) w/w) and immersion times (30, 60, 90, 120, 150 and 180 minutes) on the degree of whiteness. An increase in the concentration of anti-browning agent solution up to 5% w/w caused significant increase the degree of whiteness of porang flour and quality of porang flour. However, further increase in the concentration of anti-browning agent solution exhibited reduction in the degree of whiteness and quality of porang flour. In addition, a longer immersion time also resulted in a higher degree of whiteness of porang tuber chips. The best browning prevention conditions were through immersion of porang tuber chips in 7.5% w/w sodium metabisulfite solution for 150 minutes, from which a highest degree of whiteness was achieved (81.99).
Perencanaan Strategis Sistem Informasi Dengan Kerangka Kerja Ward & Peppard Pada PT Raja, Tbk
Authors: Susanto Irwan , Suwardiman Suwardiman , Romlah Ummu Habibah , Sensuse Dana Indra
Published: March 2021

Strategi perencanaan dalam sistem informasi menjadi peran penting untuk mencapai tujuan suatu organisasi atau perusahaan, dan hal ini harus selaras dengan strategi bisnis yang dimiliki. Teknologi Informasi/ Sistem Informasi (TI/SI) menjadi salah satu strategi bisnis perusahaan untuk meningkatkan citra perusahaan. Pengembangan model perencanaan strategis sistem informasi pada penelitian ini menggunakan metode Ward and Peppard. Penelitian dilakukan hanya di 4 perusahaan yaitu PT RAJA, Tbk selaku holding company (induk perusahaan), PT EHK selaku anak perusahaan yang bergerak di bidang gas trading, PT TIP selaku anak perusahaan yang bergerak di bidang gas infrastructure dan upstream energy provider serta PT TCM selaku anak perusahaan yang bergerak di bidang power plant dan operation and maintenance. Arah strategis yang ingin mereka raih adalah peralihan/perubahan TI/SI yang hanya memfokuskan pada direktorat finance dengan rencana implementasi selama 3 tahun. Hasil penelitian ini menunjukan model perencanaan sistem informasi strategis di perusahaan yang selaras dengan strategi bisnisnya yang sudah ada untuk menjadi sistem informasi yang terintegrasi dengan merekomendasikan 3 sistem informasi baru, eliminasi 2 sistem informasi lama, mempertahankan 4 sistem informasi lama dan usulan divisi IT baru yang terintegrasi. Penjabaran analisis kebutuhan TI/SI dilakukan dengan menggunakan analisis SWOT, CSF, PEST, dan McFarlan Strategic Grid.
Metal-Organic Framework (MOF)-Based Biomaterials for Tissue Engineering and Regenerative Medicine
Authors: Shyngys Moldir , Ren Jia , Liang Xiaoqi , Miao Jiechen , Blocki Anna , Beyer Sebastian
Published: March 2021

The synthesis of Metal-organic Frameworks (MOFs) and their evaluation for various applications is one of the largest research areas within materials sciences and chemistry. Here, the use of MOFs in biomaterials and implants is summarized as narrative review addressing primarely the Tissue Engineering and Regenerative Medicine (TERM) community. Focus is given on MOFs as bioactive component to aid tissue engineering and to augment clinically established or future therapies in regenerative medicine. A summary of synthesis methods suitable for TERM laboratories and key properties of MOFs relevant to biomaterials is provided. The use of MOFs is categorized according to their targeted organ (bone, cardio-vascular, skin and nervous tissue) and whether the MOFs are used as intrinsically bioactive material or as drug delivery vehicle. Further distinction between in vitro and in vivo studies provides a clear assessment of literature on the current progress of MOF based biomaterials. Although the present review is narrative in nature, systematic literature analysis has been performed, allowing a concise overview of this emerging research direction till the point of writing. While a number of excellent studies have been published, future studies will need to clearly highlight the safety and added value of MOFs compared to established materials for clinical TERM applications. The scope of the present review is clearly delimited from the general ‘biomedical application’ of MOFs that focuses mainly on drug delivery or diagnostic applications not involving aspects of tissue healing or better implant integration.
Biomimetic Microfluidic Platforms for the Assessment of Breast Cancer Metastasis
Authors: Sigdel Indira , Gupta Niraj , Faizee Fairuz , Khare Vishwa M. , Tiwari Amit K. , Tang Yuan
Published: March 2021

Of around half a million women dying of breast cancer each year, more than 90% die due to metastasis. Models necessary to understand the metastatic process, particularly breast cancer cell extravasation and colonization, are currently limited and urgently needed to develop therapeutic interventions necessary to prevent breast cancer metastasis. Microfluidic approaches aim to reconstitute functional units of organs that cannot be modeled easily in traditional cell culture or animal studies by reproducing vascular networks and parenchyma on a chip in a three-dimensional, physiologically relevantin vitrosystem. In recent years, microfluidics models utilizing innovative biomaterials and micro-engineering technologies have shown great potential in our effort of mechanistic understanding of the breast cancer metastasis cascade by providing 3D constructs that can mimicin vivocellular microenvironment and the ability to visualize and monitor cellular interactions in real-time. In this review, we will provide readers with a detailed discussion on the application of the most up-to-date, state-of-the-art microfluidics-based breast cancer models, with a special focus on their application in the engineering approaches to recapitulate the metastasis process, including invasion, intravasation, extravasation, breast cancer metastasis organotropism, and metastasis niche formation.
Targeted Genome Reduction of Pseudomonas aeruginosa Strain PAO1 Led to the Development of Hypovirulent and Hypersusceptible rDNA Hosts
Authors: Grosjean Mélanie , Guénard Sophie , Giraud Caroline , Muller Cédric , Plésiat Patrick , Juarez Paulo
Published: March 2021

Pseudomonas aeruginosa is a human opportunistic pathogen responsible for nosocomial infections, which is largely used as a model organism to study antibiotic resistance and pathogenesis. As other species of the genus, its wide metabolic versatility appears to be attractive to study biotechnological applications. However, its natural resistance to antibiotics and its capacity to produce a wide range of virulence factors argue against its biotechnological potential. By reducing the genome of the reference strain PAO1, we explored the development of four hypovirulent and hypersusceptible recombinant DNA hosts (rDNA hosts). Despite deleting up to 0.8% of the core genome, any of the developed strains presented alterations of fitness when cultured under standard laboratory conditions. Other features such as antibiotic susceptibility, cytotoxicity, in vivo pathogenesis, and expression of heterologous peptides were also explored to highlight the potential applications of these models. This work stands as the first stage of the development of a safe-platform strain of Pseudomonas aeruginosa that will be further optimized for biotechnological applications.
Assessment of Able-Bodied and Amputee Cyclists’ Aerodynamics by Computational Fluid Dynamics
Authors: Forte Pedro , Morais Jorge E. , Barbosa Tiago M. , Marinho Daniel A.
Published: March 2021

The aim of this study was to compare the aerodynamics of able-bodied and amputee cyclists by computational fluid dynamics. The cyclists’ geometry was obtained by a 3D scanner. Three CAD models were created as able-bodied, transtibial (Tt), and transradial (Tr) amputees. Numerical simulations were conducted up to 13 m/s with increments of 1 m/s to assess drag force. The drag ranged between 0.36 and 39.25 N for the able-bodied model, 0.36–43.78 for the Tr model and 0.37–41.39 N for the Tt model. The pressure drag ranged between 0.20 and 22.94 N for the normal model, 0.21–28.61 for the Tr model and 0.23–28.02 N for the Tt model. The viscous drag ranged between 0.16 and 15.31 N for the normal model, 0.15–15.17 for the Tr model and 0.14–13.38 N for the Tt model. The rolling resistance (RR) was higher on the able-bodied (2.23 N), followed by the Tr (2.20 N) and Tt (2.17 N) models. As a conclusion, the able-bodied cyclist showed less drag, followed by the Tt and Tr models, respectively. The RR presented higher values in the able-bodied, followed by the Tr and Tt models.
Engineering a Vascularized 3D Hybrid System to Model Tumor-Stroma Interactions in Breast Cancer
Authors: Teixeira Filipa C. , Chaves Sara , Torres Ana Luísa , Barrias Cristina C. , Bidarra Sílvia J.
Published: March 2021

The stromal microenvironment of breast tumors, namely the vasculature, has a key role in tumor development and metastatic spread. Tumor angiogenesis is a coordinated process, requiring the cooperation of cancer cells, stromal cells, such as fibroblasts and endothelial cells, secreted factors and the extracellular matrix (ECM). In vitro models capable of capturing such complex environment are still scarce, but are pivotal to improve success rates in drug development and screening. To address this challenge, we developed a hybrid alginate-based 3D system, combining hydrogel-embedded mammary epithelial cells (parenchymal compartment) with a porous scaffold co-seeded with fibroblasts and endothelial cells (vascularized stromal compartment). For the stromal compartment, we used porous alginate scaffolds produced by freeze-drying with particle leaching, a simple, low-cost and non-toxic approach that provided storable ready-to-use scaffolds fitting the wells of standard 96-well plates. Co-seeded endothelial cells and fibroblasts were able to adhere to the surface, spread and organize into tubular-like structures. For the parenchymal compartment, a designed alginate gel precursor solution load with mammary epithelial cells was added to the pores of pre-vascularized scaffolds, forming a hydrogel in situ by ionic crosslinking. The 3D hybrid system supports epithelial morphogenesis in organoids/tumoroids and endothelial tubulogenesis, allowing heterotypic cell-cell and cell-ECM interactions, while presenting excellent experimental tractability for whole-mount confocal microscopy, histology and mild cell recovery for down-stream analysis. It thus provides a unique 3D in vitro platform to dissect epithelial-stromal interactions and tumor angiogenesis, which may assist in the development of selective and more effective anticancer therapies.
Amnion-Derived Teno-Inductive Secretomes: A Novel Approach to Foster Tendon Differentiation and Regeneration in an Ovine Model
Authors: Citeroni Maria Rita , Mauro Annunziata , Ciardulli Maria Camilla , Di Mattia Miriam , El Khatib Mohammad , Russo Valentina , Turriani Maura , Santer Michael , Della Porta Giovanna , Maffulli Nicola , Forsyth Nicholas R. , Barboni Barbara
Published: March 2021

Regenerative medicine has greatly progressed, but tendon regeneration mechanisms and robustin vitrotendon differentiation protocols remain to be elucidated. Recently, tendon explant co-culture (CO) has been proposed as anin vitromodel to recapitulate the microenvironment driving tendon development and regeneration. Here, we explored standardized protocols for production and storage of bioactive tendon-derived secretomes with an evaluation of their teno-inductive effects on ovine amniotic epithelial cells (AECs). Teno-inductive soluble factors were released in culture-conditioned media (CM) only in response to active communication between tendon explants and stem cells (CMCO). Unsuccessful tenogenic differentiation in AECs was noted when exposed to CM collected from tendon explants (CMFT) only, whereas CMCOupregulatedSCXB, COL IandTNMDtranscripts, in AECs, alongside stimulation of the development of mature 3D tendon-like structures enriched in TNMD and COL I extracellular matrix proteins. Furthermore, although the tenogenic effect on AECs was partially inhibited by freezing CMCO, this effect could be recovered by application of anin vivo-like physiological oxygen (2% O2) environment during AECs tenogenesis. Therefore, CMCOcan be considered as a waste tissue product with the potential to be used for the development of regenerative bio-inspired devices to innovate tissue engineering application to tendon differentiation and healing.
Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder
Authors: Cong Shengnan , Li Jinlong , Zhang Jingjing , Feng Jingyi , Zhang Aixia , Pan Lianjun , Ma Jiehua
Published: March 2021

Lubrication disorder is a common health issue that manifests as insufficient sexual arousal at the beginning of sex. It often causes physical and psychological distress. However, there are few studies on lubrication disorder, and the complexity of circular RNA (circRNA) and the related competing endogenous RNA (ceRNA) network in lubrication disorder is still poorly known. Therefore, this study aims to build a regulatory circRNA-micro (mi)RNA-mRNA network and explore potential molecular markers of lubrication disorder. In the study, 12 subjects were recruited, including 6 in the lubrication disorder group and 6 in the normal control group. RNA sequencing was exploited to identify the expression profiles of circRNA, miRNA and mRNA between two groups, and then to construct the circRNA-miRNA-mRNA networks. The enrichment analyses of the differentially expressed (DE)-mRNAs were examined via Gene Set Enrichment Analysis (GSEA). Furthermore, the expression level and interactions among circRNA, miRNA, and mRNA were validated using real-time quantitative polymerase chain reaction (RT-qPCR) and dual-luciferase reporter assays. In the results, 73 circRNAs, 287 miRNAs, and 354 target mRNAs were differentially expressed between two groups when taking | Log2 (fold change)| > 1 and P-value < 0.05 as criteria, and then the results of GSEA revealed that DE-mRNAs were linked with “vascular smooth muscle contraction,” “aldosterone regulated sodium reabsorption,” “calcium signaling pathway,” etc. 19 target relationships among 5 circRNAs, 4 miRNAs, and 7 mRNAs were found and constructed the ceRNA network. Among them, hsa-miR-212-5p and hsa-miR-874-3p were demonstrated to be related to the occurrence of lubrication disorder. Eventually, consistent with sequencing, RT-qPCR showed that hsa_circ_0026782 and ASB2 were upregulated while hsa-miR-874-3p was downregulated, and dual-luciferase reporter assays confirmed the interactions among them. In summary, the findings indicate that the circRNA-miRNA-mRNA regulatory network is presented in lubrication disorder, and ulteriorly provide a deeper understanding of the specific regulatory mechanism of lubrication disorder from the perspective of the circRNA-miRNA-mRNA network.