bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial Effect Of Natural Oils – An Opportunity To Solve The Problem Of Antibiotic Resistance On The Example Of Pseudomonas Spp.
Authors: Leja Katarzyna , Szudera-Kończal Kamila , Myszka Kamila , Czaczyk Katarzyna
Published: February 2020

Presently, the overuse of antibiotics is a great problem all over the world. The reason for this phenomenon is both primary and secondary resistance. Primary resistance is a congenital feature of microbes and does not depend on its contact with a drug. It is chromosomally coded and cannot be transmitted to other species of bacteria. Secondary resistance, on the other hand, develops as a result of contact with the antibiotic substance. Genes located in plasmids are responsible for the formation of this type of resistance. One plasmid often contains resistance genes for several different antibiotics. Plasmids can transfer gene-encoded resistance from one bacterial cell to another by conjugation and transduction. As a result of the overuse of antibiotics in humans and animals, a growing number of infections – such as pneumonia, salmonellosis, tuberculosis, and gonorrhea – are becoming more troublesome to treat. Antibiotic resistance leads also to longer hospital stays, higher medical costs and finally increased mortality. Now people are finally becoming aware of the consequences of the overuse of antibiotics. Thus, interest in natural bacteriostatic materials, such as plant essential oils, has observably grown. A number of scientific studies have confirmed the antimicrobial activity of plant-derived essential oils against pathogenic bacteria, including Pseudomonas aeruginosa. A very important advantage of plant oils is the fact that they are active in low, sub-lethal concentrations, without provoking the acquisition resistance mechanisms in bacteria. The aim of this review was to explain the mechanisms of antibiotic resistance formation on the example of Pseudomonas aeruginosa and to demonstrate that it is worth looking for alternative treatment methods which can lead to limiting the use of antibiotics. Finally, this work tries to explain how the oils work.

1.Introduction. 2. The characteristics of Pseudomonas genus. 2.1. Pseudomonas aeruginosa. 3. The mechanisms of antibiotic resistance in Pseudomonas spp. 3.1. Intrinsic resistance. 3.2. Adaptive resistance. 3.3. Plasmid resistance. 4. The most common resistances of clinical P. aeruginosa strains to antibiotics. 4.1. Resistance to aminoglycosides. 4.2. Resistance to fluoroquinolones. 4.3. Resistance to cephalosporins. 5. Essential oils from plants as a natural alternative for antibiotics. 5.1. Antibacterial activity of plant EOs against Pseudomonas spp. 5.2. How EOs work on the bacteria cell. 6. Summary
Carbapenemase Of Intestinal Rods – The Beginning Of Post-Antibiotic Era?
Authors: Chmielewska Sylwia Joanna , Leszczyńska Katarzyna
Published: February 2020

In recent years in Poland as well as globally at an alarming rate, the number of bacteria producing mechanisms of antibiotic resistance has been increased. The major source of concern is the emergence and dissemination of carbapenem-resistant Enterobacteriaceae (CRE). Carbapenems are considered as last resort drugs for the treatment of multidrug-resistant (MDR) bacterial infections. At the present time the greatest menaces to public health are strains producing KPC (Klebsiella pneumoniae carbapenemases), NDM (New Delhi Metallo-β-lactamase) and OXA-48 (Oxacillinase-48). Carbapenemase-producing Enterobacterales have been resistant to most and sometimes even to all drugs that would be considered for treatment. Therefore, the accurate therapeutic options for the treatment of infections due to CRE strains are limited to the following antibiotics: colistin, tigecycline, fosfomycin, and aminoglycosides. Moreover, combination therapy containing two or more antibiotics has been recommended for the treatment of severe infections caused by carbapenemase-producing Enterobacterales. Due to the rapid spread of carbapenem-resistant strains and the lack of new antibiotic drug development, there is an urgent need to broaden our knowledge regarding antibiotic resistance.

1. Introduction. 2. Carbapenemases. 2.1. Metallo-β-lactamases. 2.2. Class A Carbapenemases. 2.3. Class D Carbapenemases (OXA). 3. Review of antibiotic treatment options of infections due to carbapenem-resistant strains. 3.1. Colistin. 3.2. Fosfomycin. 3.3. Tigecycline. 3.4. Aminoglycosides. 3.5. Carbapenems. 3.6. Mechanism of NDM – likely antibiotic/ chemotherapeutics could be used in the therapy. 3.7. Mechanism of KPC – likely antibiotic/ chemotherapeutics could be used in the therapy. 3.8. Mechanism of OXA-48 – likely antibiotic/ chemotherapeutics could be used in the therapy. 4. Summary
“Stepping Stones” in Urban Greenways: Design Strategy of Roof Garden in Jiangbei New District, Nanjing, China
Authors: Liu Wenhui , Zhang Hong , Ni Jiaxin
Published: February 2020

This paper focuses on the design strategy of roof gardens, analyzes the relationship between aerial greening from the overall shape of urban space, and discusses the greening spots effect of “stepping stones” in urban greenways. Taking the green corrider between the green space of the Yangtze River wetland and the green space of the Laoshan Mountain as a sample, the roof garden is analyzed as the impact of the stepping stones of the birds on the urban space shape control and height control. Afterwards, it researches the modular technology which can be adapted to building various types of roof gardens.
Removal of phenol from aqueous solutions by magnetic oxide graphene nanoparticles modified with ionic liquids using the Taguchi optimization approach
Authors: Gholami-Bonabi Leila , Ziaefar Nasim , Sheikhloie Hossein
Published: February 2020

A magnetic graphene oxide nanocomposite modified by the ionic liquid 1-amino-3-methylimidazole chloride (LI-MGO) was prepared by the chemical coprecipitation method as a phenol adsorbent for the treatment of contaminated aqueous environments. The structure of the prepared nanocomposite was investigated using Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy. The prepared nanoparticles exhibited a BET (Brunauer–Emmett–Teller) specific surface area of 110.44 m2 g−1 and total pore volume of 0.2839 cm3 g−1. The results revealed that the adsorption process had the highest phenol removal percentage (95.3%) under optimum conditions (pH = 3, nanocomposite concentration = 0.04 g/l at room temperature). Kinetic studies showed a significant fit to the pseudo-second-order kinetic model (R2 > 0.9997) giving an equilibrium rate constant (K2) of 0.000119 gmg−1 min−1 for phenol loaded. The experimental adsorption data were better fitted with the Langmuir isotherm model than with the Freundlich isotherm model. To further investigate the phenol removal optimization process of the modified magnetic nanoparticles, and to determine the effect of each parameter on the adsorption process, the Taguchi optimization approach was used. The adsorption of these synthesized nanocomposites is among the low-cost, high-efficiency processes that can be used for the reduction/elimination of environmental pollutants, especially in aqueous environments.
Energy saving for air supply in a real WWTP: application of a fuzzy logic controller
Authors: Bertanza G. , Menoni L. , Baroni P.
Published: February 2020

An unconventional cascade control system, for the regulation of air supply in activated sludge wastewater treatment plants (WWTPs), was tested. The dissolved oxygen (DO) set point in the aeration tank was dynamically calculated based on effluent ammonia concentration, following a fuzzy logic based approach. First, simulations were conducted, according to the BSM2 protocol, for a general comparison with more conventional control strategies. It turned out that the effluent quality could be improved by 7–8%, based on the EQI parameter. Moreover, the aeration energy requirement could be reduced up to 13%. Subsequently, the system was installed in a full-scale WWTP. While stably complying with the ammonia effluent standard (10 mg/L), excess air supply was prevented, and a reduction of the specific power consumption (kWh/kgCODremoved) of 40–50% was recorded with respect to the previously installed PID controller (fixed DO set point).
Diaspora prawosławna we Wrocławiu. Praktyczne problemy socjalizacji i edukacji religijnej (perspektywa rodzica)
Authors: Sanecka Anna
Published: February 2020

Bycie członkiem mniejszości wiąże się z utrudnieniami w funkcjonowaniu w różnych obszarach życia. Utrudnienia te dotyczą także edukacji oraz życia religijnego. Są one skutkiem zarówno czynników natury obiektywnej, takich jak przepisy prawa, organizacja nauczania religii czy tradycja religijna, a również subiektywnej, czyli np. braku gotowości rodziców lub problemów z wytłumaczeniem dziecku jego „odmienności” od rówieśników wyznających religię większościową. Tego typu trudności doświadczają także członkowie diaspory prawosławnej we Wrocławiu – szczególnie rodzice, ale też dzieci po osiągnięciu pewnego wieku i bardziej już świadome swej odrębności religijnej. Artykuł przedstawia praktyczne problemy oraz szanse związane z socjalizacją religijną oraz nauczaniem religii widziane oczami prawosławnego rodzica.
ODOUR POLLUTION ASSESSMENT THROUGH INDIRECT METHODS BASED ON THE MONITORING OF TECHNOLOGICAL PARAMETERS - CASE STUDY
Authors: Bucur Elena , Danciulescu Valeriu , Tanase Gheorghita , Lehr Carol Blaziu , Vasile Andrei
Published: February 2020

The odours in the ambient air, through the discomfort that they induce, represent an actual problem for the communities located nearby companies with technological processes that emit in the air different strong and unpleasant odorous substances. The standard method for odour assessment involves measuring the concentration through dynamic olfactometry according with SR EN 13725:2003, a very complex method that requires specialized working staff and expensive equipment. The paper presents an indirect method for odour assessment in the ambient air, based on monitoring the process and meteorological data - Predictive Emission Monitoring Systems (PEMS) and it is applied to a livestock farm. Using the multiple regression analysis of the monitoring data for the most important specific technological and meteorological parameters it can be developed a mathematical model that could be used for the calculation of odour concentration in air, without the necessity of direct measurement, after the initial step. For the case study presented in the paper, the distance between the slurry lagoon was identified as a significant statistical parameter that can determine in a proportion of 72% the concentration of odour in the ambient air nearby the farm; the margin of error for odour concentration assessment, according to the model validation tests, is ± 8%, acceptable value for an estimation method by mathematical modelling.
BIODEGRADATION OF ANTIBIOTICS: THE BALANCE BETWEEN GOOD AND BAD
Authors: Galaon Toma , Banciu Alina , Chiriac Florentina Laura , Nita-Lazar Mihai
Published: February 2020

The worldwide population rise corroborated with the raise of the health-care standards have generated an escalation of the antibiotic production and uncontrolled usage. The subsequent effects of this escalation have led to an increase of the antibiotic resistance rates, Romania is in the top of the EU countries regarding the antibiotic resistance rates, and to a continuous presence in the environment, including the aquatic environment. Unfortunately, the present design of the classical WWTPs is not optimized for the efficient removal of antibiotics since these compounds may have highly soluble and polar molecular structures. Instead, antibiotics removal using microorganisms could be an ecofriendly solution to this environmental issue, as long as their antibiotic degradation structures are not more toxic than the antibiotic itself. In the present review, we focus on the environmental presence and biodegradation of the most commonly used antibiotics as well as on their biodegradation, based on bacterial model, monitored by mass-spectrometric methods.
Identification of Salmonella Typhimurium Peptidyl-prolyl cis-trans Isomerase B (PPIase B) and Assessment of their Role in the Protein Folding
Authors: Kumawat Manoj , Karuna Irungbam , Ahlawat Neeraj , Ahlawat Sushma
Published: February 2020

Background:

Peptidyl-prolyl cis-trans isomerase (PPIases) enzyme plays a vital role in
protein folding. It catalyses the cis-trans isomerisation of peptide bonds, an essential step for newly
synthesized protein to acquire its correct functional conformation in both prokaryotes and
eukaryotes.

Objective:

The present study showed the biochemical and molecular characterisation of
cyclophilins (PpiB), a type of peptidyl-prolyl isomerases proteins from the pathogenic bacteria
Salmonella Typhimurium.

Methods:

Salmonella Typhimurium is one of the leading serovars responsible for human and
animal salmonellosis globally, with the majority of human cases originating through the food chain.
Here successful expression and purification of PpiB protein have been demonstrated and LC-MS
based analyses showed high protein score and similarity with other PPi protein. Further the
enzymatic activity of the purified recombinant PpiB was determined using Succinyl-Ala-Phe-Pro-
Phe-p nitroanilide as substrate and enzyme-catalysed reaction.

Result:

Km and Vmax were calculated and found to be Vm = 1.023 ± .06400 min/μg, Km = 0.6219
± 0.1701 μM, respectively. We have reported for the first time the presence of Salmonella PPIase-B
(PpiB) protein isoforms in salmonella genome having PPi activity.

Conclusion:

Taken together, our data clearly showed that Salmonella Cyclophilin B (PpiB) protein
is active and involved in diverse biological processes and highly similar to the different domain of
Cyclophilin proteins.
Curcumin Attenuates Cerebral Ischemia-reperfusion Injury Through Regulating Mitophagy and Preserving Mitochondrial Function
Authors: Wang Weiwei , Xu Jiaping
Published: February 2020

Background:

Curcumin, the complex extracted from the traditional edible herb, has a
wide range of pharmacological effects. A great deal of studies has demonstrated that curcumin
could protect against cerebral ischemia-reperfusion (I/R) injury. In the present study, we aimed to
test the hypothesis that curcumin reduces brain damage via regulating mitophagy and preserving
mitochondrial function. To clarify the potential effect and mechanism of curcumin on cerebral I/R,
we utilize MCAO followed by reperfusion rats and OGD/R neurons as cerebral I/R in vivo and in
vitro, respectively.

Methods:

We determined the cellular ROS levels and mitochondrial function, including mitochondrial
membrane potential (MMP), ATP levels, state 3 respiration and state 4 respiration. We also
detected the levels of mitophagy by immunofluorescent staining and western blotting.

Results:

Results found that curcumin decreased neurological deficit scores, infarct volume and
morphological changes of neurons in rats after brain I/R injury. Curcumin also reduced the levels
of ROS while increased MMP, ATP levels and state 3 respiration to prevent the impairment of mitochondrial
function from cerebral I/R. Furthermore, curcumin enhanced the co-localization of
LC3B and mitochondrial marker VDAC1, the ratio of LC3-II to LC3-I, improving cerebral I/Rinduced
mitophagy.

Conclusion:

In conclusion, our results suggest that curcumin protects against cerebral I/R injury
by improving mitophagy and preserving mitochondrial function.
Analysis of Oxaliplatin Resistance in Colorectal Cancer Cells by Combined Proteomics and Phosphoproteomic
Authors: Yang Rui , Feng Kunli , Cao Yanhong , Wang Hao , Wang Baolong
Published: February 2020

Background:

Oxaliplatin(Oxa) is a major chemotherapy drug for colorectal cancer.
However, drug resistance is a major cause of treatment failure for late-stage colorectal cancer.
Therefore, it is necessary to explore the mechanism of resistance to oxaliplatin in HCT116 colorectal
cancer cells.

Objective:

Therefore, this study explored the mechanisms of HCT116 cells resistance to oxaliplatin
by combining the results of proteomic and phosphoproteomic analyses.

Methods:

In this study, firstly,we constructed oxaliplatin-resistant HCT116 cells called HCT116/
Oxa. Then, we conducted a quantitative study of phosphoproteomics in HCT116 and HCT116/
Oxa cells via TMT labeling, bio-material-based PTM enrichment, HPLC fractionation, and
LC-MS/MS analyses. At the same time, we applied TMT/iTRAQ labeling, HPLC fractionation,
and LC-MS/MS to conduct proteomic and phosphoproteomic analyses of the cell lines. Finally, we
analyzed the results from Gene Ontology (GO), protein domain, and Kyoto Encyclopedia of Genes
and Genomes (KEGG) pathways using the 1.5 change rate as a meaningful change threshold.

Results:

Our analysis confirmed the previously described mechanisms of colon cancer resistance
and revealed the important role of phosphorylation in drug resistance.

Conclusion:

Collectively, this study provides a new direction for the study of oxaliplatin resistance
in colorectal cancer.
Design, Synthesis and Anticancer Evaluation of Acetamides Comprising 1,2,3-triazole, 1,3,4-thiadiazole and Isothiazolo[4,3-b]pyridine Rings
Authors: Shahinshavali Shaik , Poojith Nuthalapati , Guttikonda Venkat Rao , Sreenivasulu Reddymasu , Basaveswara Rao Mandava Venkata
Published: February 2020

We have synthesized a library of new 1,2,3-triazole incorporated 1,3,4-thiadiazoleisothiazolo[
4,3-b]pyridine derivatives 12a-j and have screened these products for their anticancer
activities against four human cancer cell lines such as MCF-7 (breast cancer), A549 (lung cancer),
DU-145 (prostate cancer), and MDA MB-231 (breast cancer) using MTT assay with etoposide as a
positive control. Among them, compound 12e has shown excellent activities against MCF-7, A549,
DU-145, and MDA-MB-231 with IC50 values of 0.53±0.055 μM, 0.18±0.077 μM, 0.10±0.082 μM, and
0.92±0.041 μM, respectively.
Trifunctionalized Allenes. Part IV. Cyclization Reactions of 4-Phosphorylated 5-Hydroxyhexa-2,3-dienoates
Authors: Ismailov Ismail E. , Ivanov Ivaylo K. , Christov Valerij Ch.
Published: February 2020

This manuscript focuses on the reactions of 4-phosphorylated 5-hydroxyhexa-2,3-dienoates
with protected or unprotected hydroxy groups involving 5-endo-trig cyclizations. Reactions with electrophiles
result in mixtures of the 2,5-dihydro-1,2-oxaphosphole-5-carboxylates and the 5-phosphorylfuran-
2(5H)-ones by competitive electrophilic cyclization due to the neighboring phosphonate (phosphine
oxide) and the carboxylate groups participation. 4-Phosphorylated 5-hydroxyhexa-2,3-dienoates
were smoothly transformed into the corresponding 4-phosphoryl-2,5-dihydrofuran-2-carboxylates by
using 5 mol % of a silver salt as a catalyst in the 5-endo-trig cycloisomerization reaction.
Exploring the Neighbouring Group Participatory Mechanism in Glycosylation Reaction
Authors: Sharma Kamlesh
Published: February 2020

Glycosyl donors have been experimentally shown to have a high tendency for acyl transfer
to the alcohol nucleophile as a major side product during glycosylation reactions. Therefore, a neighbouring
group participatory mechanism of glycosylation is explored using D-galactopyranose based
donor having 2-O-acyl functionality by employing density functional theory. The reaction proceeds via
galactopyranosyl dioxolenium ion as a stable intermediate, which leads to the formation of α-glycoside
4, orthoester (5 or 6) and acyl transfer 7 as side products. The mechanism of the stereoselective formation
of β-glycoside is investigated. Moreover, all the possible intermediates and transition states
have been explored.
Overview of Therapeutic Effects of Statins on Inflammatory Diseases Through Regulating Adhesive Molecules
Authors: Meng Yibin , Wang Youhan , li Yibing , Chon Song , Hao Dingjun
Published: February 2020

Simvastatin, lovastatin, rosuvastatin, pravastatin and cerivastatin belong to the statin family,
which are competitive inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A. As the rate-limiting
enzyme in the pathway of cholesterol metabolism, statins are classically prescribed to patients as lipidlowering
agents. However, statins also possess several extra bioactivities, including anti-inflammatory,
antiviral and anti-tumor. Interestingly, the most essential mechanism of these activities is that statins
could regulate the expression of cell adhesion molecules (CAMs), especially, targeting lymphocytes
function-associated molecules (LFA)-1, macrophage (Mac)-1 and intercellular adhesion molecules
(ICAM)-1. Therefore, in this paper, we discussed the regulatory effect of statins on CAMs among different
diseases. In addition, we provided speculation for the role of statins in treating orthopedic disease.
Archeologie in musea: een passend verleden voor de Sami?
Authors: van den Berg Mathilde
Published: February 2020

A Sami past.

The Sami are still struggling for general acceptance of their identity and cultural expression. They are the indigenous population of Fennoscandia, and although now mostly associated with reindeer herding, historically their subsistence was based mostly on fishing, hunting, agriculture, animal husbandry, and only small-scale reindeer herding. In this paper it is probed how contemporary majority and Sami museums convey information about the Sami and their past, with a special focus on the role of archaeology. This is important because museums have an active role in the creation of knowledge and identity. There are several discrepancies between what archaeology is and can present, and how the Sami see their culture and past. Archaeology works with linear time, and focuses on material culture that is, landscape-wise, taken out of context. By contrast, Sami culture emphasizes the importance of material culture within the landscape, feels affiliated with circular time and nature, and does not accept all material culture that archaeology classifies as Sami. In the case of the Sami, archaeology is a less-than-ideal way to communicate about their past and culture.
Q130: surveys op het terrein van een hellenistische en Romeinse boerderij in zuid-Italië
Authors: van Leusen Martijn , Oome Neeltje
Published: February 2020

Q130: surveys over the site of a Hellenistic-Roman farm in southern Italy.

This article reports on the results of survey experiments conducted by a GIA team in 2010 over the site of a Hellenistic-Roman farm, Q130, located in the foothills enclosing the Sibaritide coastal plain in southern Italy. The experiments show that a ‘quick scan’ surface survey method achieves good results in locating the main structures, matching the results of a gradiometer survey conducted simultaneously, and that further useful chronological and functional detail was obtained by ‘total’ survey and in-field classification of the finds. The socio-economic context of this farm site must obviously be sought in the nearby Hellenistic colony of Thourioi and its Roman successor Copiae, but further questions about the character and chronology of the site can only be answered by excavation.
Wat de Yesser nonnen aten: Voedselconsumptie in een Cisterciënzer nonnenklooster te Essen, Groningen
Authors: van Rijn Morvenna , Koolstra Francis , Arnoldussen Stijn
Published: February 2020

What the Yesser nuns ate: Food consumption in a Cistercian convent in Essen, Groningen. Archaeological research of monasteries primarily focuses on reconstructing the monastic architecture and the use of space, often referring to historical sources. During such research projects, food consumption by the monastics is often neglected in archaeobotanical and -zoological research. This paper presents the results of research carried out on plant and animal remains which were recovered during the 2017 excavation of the former convent of Yesse at Haren, which functioned from 1215 until 1594. This interdisciplinary research shows that it is possible to nuance what was eaten by the convent’s residents, which contributes to a better understanding of the products that were consumed in medieval monastic institutions in the Netherlands.
GENDER DALAM PERSPEKTIF ALQUR’AN
Authors: Ratnasari Dwi
Published: February 2020

Perbedaan anatomi biologis laki-laki dan perempuan merupakan sunnatullah yangmasih menyimpan beberapa masalah, baik dari segi substansi kejadian maupun peran yangdiemban dalam kehidupan bermasyarakat. Interpretasi budaya terhadap perbedaan biologisinilah yang disebut gender. Alquran memang tidak merinci pembagian kerja antara lakilakidan perempuan, akan tetapi Alquran cenderung mempersilahkan kepada kecerdasanmanusia untuk mengelola pembagian peran di antara mereka, -- dengan mengutamakanprinsip kesejajaran dan kemitraan--, atas dasar musyawarah dan saling tolong menolong.Alquran sebagai rujukan nilai-nilai ajaran Islam, dalam membicarakan masalah penciptaanmanusia tidak menyebut jenis kelamin secara khusus, melainkan dengan menyebutmanusia secara umum. Hal ini menunjukkan bahwa manusia, baik laki-laki maupunperempuan tidak memiliki perbedaan dalam penciptaannya sehingga mereka memilikikedudukan yang sama dalam kemanusiaannya, tidak ada yang lebih tinggi ataupun lebihrendah. Sebab prinsip utama dalam ajaran Islam adalah persamaan di antara seluruhmanusia, baik antara laki-laki dan perempuan maupun antar suku, bangsa dan keturunan.Perbedaan yang ditegaskan dalam Alquran yang kemudian dapat meninggikan ataupunmerendahkan martabat seseorang adalah nilai pengabdian dan ketakwaannya terhadapAllah swt.Biological anatomy differences of males and females have many problems, bothfrom the real substance and task forces in the society. Gender is defined as culturalinterpretation toward biological differences. Holy Qur’an doesn’t explain about task forcesboth males and females, but it tends to allow human intelligence to manage everythingwith equality and cooperative relationship which include discussion and kindness. HolyQur’an as reference of Islamic values, it didn’t talk aboout sexes when it discussed howpeople where created, but it explained human in general. This shows that humans eithermales or females doesn’t have differences so that they have the same position. Primaryprinciple of Islam is the equality among people, both males and females, contries, ethnics,and generation. Difference explained could go up or go down human prestige which is therepresentation of service and belief to the God.
Model bahan ajar membaca pemahaman berbasis teks dengan pendekatan content language integrited learning
Authors: Nurbaya St , Rahayu Dwi Hanti
Published: February 2020

This study aimed to develop reading material teaching based on text with a content language integrated learning approach for students of PBSI FBS UNY. Development design followed the design model developed by Willis, known as the R2D2 model (1995), with steps (1) defining 2) planning and development, 3) dissemination. Products whose developed are text-based reading teaching materials with the CLIL approach. The products have been assessed by peers, reading learning experts, and lecturers of reading comprehension courses. There are five types of texts developed into teaching materials, namely; 1) description text, exposition text, argumentation text, editorial text, and research proposal text. Each text is used as a learning unit. Each learning unit was divided into; 1) learning objectives, 20 teaching materials, 3) texts, and 4) evaluation of learning. The assessment instrument used the teaching material assessment rubric with 4 components, scaled 1-4. The four assessment components; 1) content eligibility with a mean value of 23.00 or with a very good category, 2) language with a mean value of 14.00 or good category, 3) presentation with a mean of 19.30 or in a very good category while the component, 4) the design gets a mean value of 14.60 or good category. Overall, research development on instructional materials is at an average rate of 17.72 or a good category.Penelitian ini bertujuan mengembangkan bahan ajar membaca pemahaman berbasis teks dengan pendekatan content language integrited learning untuk mahasiswa PBSI FBS UNY. Desain pengembangan mengikuti model desain yang dikembangkan oleh Willis yang lebih dikenal dengan model R2D2 (1995,) dengan langkah (1) pendefinisian 2) perencanaan dan pengembangan, 3) penyebarluasan. Produk temuan hasil pengembangan adalah bahan ajar membaca berbasis teks dengan pendekatan CLIL. Produk telah dinilai oleh teman sejawat, pakar pembelajaran membaca, dan dosen-dosen mata kuliah membaca pemahaman. Jenis teks yang dikembangkan menjadi bahan ajar ada lima, yaitu; 1) teks deskripsi, teks ekposisi, teks argumentasi, teks editorial, dan teks proposal penelitian. Masing-masing teks dijadikan unit pembelajaran. Tiap unit pembelajaran terbagi atas ; 1) tujuan pembelajaran, 20 materi ajar, 3) teks yang dibaca, dan 4) evaluasi pembelajaran. Instrumen penilaian menggunakan rubrik penilaian bahan ajar dengan 4 komponen yakni berskala 1-4. Keempat komponen penilaian meliputi; 1) kelayakan isi dengan rerata nilai 23.00 atau dengan kategori sangat baik , 2) kebahasaan dengan rerata nilai 14.00 dan terkategori baik, 3 ) penyajian dengan rerata 19.30 atau berada pada kategori sangat baik, sedangkan komponen , 4) desain mendapatkan rerata nilai 14.60 dengan kategori baik. Secara keseluruhan, penelitian terhadap bahan ajar hasil pengembangan berada pada angka rerata 17,72 atau berada pada kategori baik.
PEMBIASAAN MENGGOSOK GIGI UNTUK MENJAGA KESEHATAN GIGI DAN MULUT
Authors: Arumsari Fitria
Published: February 2020

Berawal dari banyaknya anak yang tidak gosok gigi saat pergi ke sekolah yang dikarenakan kurangnya kesadaran orang tua tentang pentingnya menjaga  kesehatan gigi dan mulut anak dan juga kesibukan orang tua dalam bekerja, maka guru membuat pembiasaan yaitu menggosok gigi di sekolah. Gosok gigi dilakukan setiap hari sebelum proses belajar mengajar berlangsung dan diikuti oleh seluruh siswa TK dari kelompok A dan B. Dalam pelaksanaannya guru menggunakan metode demonstrasi. Guru memberi contoh cara menggosok gigi yang benar dan anak mengikuti. Hasil dari kegiatan ini diharapkan anak memahami pentingnya menjaga kesehatan gigi dan mulut. Selain itu anak menjadi rajin menggosok gigi di sekolah maupun di rumah, sehingga anak dapat memiliki gigi yang sehat.Kata kunci: Pembiasaan, gosok gigi, anak TK
MENULIS ITU MENYENANGKAN
Authors: Syamsidah Syamsidah
Published: February 2020

Menulis merupakan aktifitas menuangkan ide berupa pengalaman nyata atau cerita rakyat yang disebut dengan tulisan non fiktif dan cerita khayalan yang disebut dengan tulisan fiktif.  Menulis membutuhkan beberapa persiapan antara lain  motivasi, dukungan sahabat atau bisa bergabung dalam komunitas penulis serta alat tulis seperti komputer. Beberapa aspek tersebut merupakan komponen dalam persiapan internal, persiapan eksternal dan persiapan peralatan. Cara menulis perlu diketahui penulis pemula agar menulis menjadi aktifitas yang menyenangkan. Langkah yang perlu dilakukan yaitu memulai menentukan jenis tulisan fiksi atau nonfiksi kemudian membuat kerangka atau peta konsep agar hasil tulisan bisa berkualitas dan dapat dipublikasikan. Hasil tulisan yang dapat dipublikasikan dalam bentuk buku maupun jurnal dapat memberi keuntungan berupa royalti dan menambah angka kredit untuk kenaikan pangkat. Kata Kunci: Menulis, Publikasi
KEMAMPUAN MENULIS AWAL MELALUI PERMAINAN KREATIVITAS
Authors: Halimah Nur
Published: February 2020

Perkembangan menulis awal anak tidak akan berkembang begitu saja seiring dengan kematangan usia, tetapi adanya dorongan dari luar maka perkembangan tersebut dapat terjadi. Kegiatan bermain yang dilakukan bertujuan untuk mengembangkan menulis permulaan pada anak usia 5-6 tahun melalui kegiatan bermain kreatif pada anak SD tingkat rendah di SD Negeri 1 Pining, Kecamatan Pining Kabupaten Gayo Lues. Kemampuan menulis awalpada kelas rendah masih sangat kurang itu disebabkan keterbatasan guru dalam memberikan kegiatan yang kurang menarik bagi anak. Permainan kreatif sebagai salah satu alternatif yang bisa dilakukan guru agar dapat mengembangkan menulis awal dengan kegiatan yang menimbulkan rasa senang. Kata Kunci : perkembangan menulis awal, bermain kreatif.
BUDIDAYA JAMUR TIRAM PUTIH (Pleurotus ostreatus) SEBAGAI PERCONTOHAN DAN UNIT USAHA BUDIDAYA JAMUR (UUBJ) DI UNIVERSITAS CENDERAWASIH
Authors: Agustini Verena , Sufaati Supeni , Bharanti Bonifasia Elita , Runtuboi Dirk Yanes
Published: February 2020

Usaha jamur tiram putih (Pleurotus ostreatus) di Papua merupakan “bisnis baru” yang sangat menjanjikan. Unit Usaha Budidaya Jamur (UUBJ) yang merupakan implementasi program PPUPIK Jurusan Biologi FMIPA Universitas Cenderawasih (Uncen) telah merintis budidaya jamur tiram sejak tahun 2016. Jamur segar yang dihasilkan 15 kg per minggu dengan harga Rp. 70.000,-/kg. Selain sebagai profit, UUBJ juga menjadi sarana pembelajaran bisnis (wirausaha) bagi mahasiswa, alumni dan kelompok masyarakat. Solusi atau teknologi untuk menumbuhkan dan membentuk jiwa kewirausahaan adalah Entrepreunership Capacity Building (ECB) dan Participatory Action Learning System (PALS). Unit ini telah menghasilkan 5 orang entrepreuner baru di bidang usaha jamur tiram putih yang berasal dari mahasiswa  dan alumni.
Penyuluhan Alat Deteksi Kesadahan Dalam Air Berbasis Light Dependent Resistor Di Kelurahan Giritontro, Kecamatan Giritontro, Kabupaten Wonogiri
Authors: Sumarna Sumarna , Agustikasa Dyah Kurniawati , Purwanto Agus , Kadarisman Nur , Nugraheni Anggiyani Ratnaningtyas Eka , Dina Dina
Published: February 2020

Beberapa daerah di Wonogiri memiliki tanah yang mengandung kapur, sementara itu sebagian masyarakat mengonsumsi air yang berasal dari dalam tanah. Pada kegiatan pengabdian kepada masyarakat tahun 2016 ditemukan permasalahan dalam masyarakat di kelurahan Wonogiri yaitu sulitnya mendeteksi adanya kapur dalam air yang mereka konsumsi. Sebagai akibatnya banyak masyarakat yang menderita penyakit dalam yang diakibatkan pengendapan kapur di dalam tubuh mereka seperti penyakit ginjal. Oleh karenanya, tim PPM Fakultas MIPA Universitas Negeri Yogyakarta membangun sistem pendeteksi adanya kapur dalam cairan berbasis Light Emitting Diode (LED) dan Light Dependent Resistor (LDR). LED digunakan untuk menyinari cairan dengan kadar kapur yang berbeda-beda, kemudian LDR akan mendeteksi cahaya LED yang melewati cairan tersebut. Besar kecilnya nilai luaran LDR akan bergantung kadar kapur dalam cairan. Masyarakat sangat antusias dan mulai menggunakan alat ini untuk mendeteksi adanya kapur di air yang mereka konsumsi. Kata kunci: Kesadahan, LDR, LED Workshop On Detector of Water Hardness Based On Light Dependet Resistor In Giritontro Village, Giritontro District, Wonogiri RegencyAbstract           Some areas in Wonogiri contain hardness in its soil, while some people consume water that come from the soil. In community service activity in 2016, we found problems in the community in Giritontro, Wonogiri that is the difficulties to detect the hardness in the water that people consume. As a result, many people who suffer from internal diseases caused by the deposition of lime in their bodies such as kidney disease. Therefore, the PPM team of the Faculty of Mathematics and Natural Sciences of Yogyakarta State University built a hardness detection system in liquid based Light Emitting Diode (LED) and Light Dependent Resistor (LDR). LEDs are used to irradiate fluids with different lime levels, then LDR will detect the LED light passing through the liquid. The size of the LDR output value will depend on the lime content in the liquid. People are very enthusiastic and start using this tool to detect the presence of limestone in the water they consume. Keywords: Hardness, LDR, LED
Gambaran Kepentingan Politik Kelompok Komunis di Indonesia:Pemogokan Buruh di Delanggu 1948
Authors: * Dyah Ayu Anggraheni Ikaningtyas
Published: February 2020

Penelitian ini bertujuan untuk membahas mengenai pemogokan buruh di Delanggu tahun 1948 dan membahas sikap pemerintah dengan adanya pemogokan buruh di Delanggu. Metode penelitian sejarah dengan heuristik, verifikasi, interpretasi, dan penulisan. Sumber penelitian berupa arsip kepolisian koleksi Arsip Nasional Indonesia, Encyclopedie van Nederlansch-Indië, serta buku penunjang. Hasil penelitian menyimpulkan bahwa pemogokan buruh di Delanggu berkaitan dengan adanya pergerakan partai komunis, tidak hanya semata-semata persoalan perut kaum buruh. Kekecewaan kelompok komunis terhadap pemerintah Indonesia, dengan memobilisasi kaum buruh untuk melakukan aksi pemogokan. Aksi ini menambah suasana panas suhu politik kala itu. Pemogokkan di Delanggu menjadikan terbengkalainya perkebunan rosella dan kapas yang mensuplai bahan baku pembuatan karung goni. Gerakan yang ternyata juga bermuatan politik dari komunis ini mengakibatkan kerugian bagi pabrik karung goni tentu saja juga merugikan negara, karena pabrik karung goni Delanggu diambil alih pemerintah RI setelah proklamasi kemerdekaan Indonesia. Kata kunci: Buruh, Pemogokkan, Delanggu
Keefektifan Metode Problem Solving dalam Pembelajaran Pkn untuk Pengembangan Kemampuan Berpikir Kritis dan Sikap Nasionalisme di SMA Negeri 1 Suela Lombok Timur
Authors: * Ika Tijayanti, Marzuki
Published: February 2020

Penelitian ini bertujuan untuk mengetahui keefektifan metode problem solving dalam pembelajaran PKn untuk pengembangan kemampuan berpikir kritis dan sikap nasionalisme di SMA Negeri 1 Suela Lombok Timur. Penelitian dilaksanakan pada bulan Januari sampai Februari 2013 dengan menggunakan analisis MANOVA faktorial dua jalur pada taraf signifikansi 5% (= 0,05). Hasil penelitian ini adalah sebagai berikut: 1) kemampuan berpikir kritis siswa yang belajar menggunakan metode problem solving lebih tinggi dibandingkan dengan siswa yang belajar menggunakan metode konvensional; 2) sikap nasionalisme siswa yang belajar menggunakan metode problem solving tidak menunjukkan perbedaan rerata yang signifikan dengan siswa yang belajar menggunakan metode konvensional; 3) kemampuan berpikir kritis siswa tidak menunjukkan perbedaan yang signifikan antara rerata pada siswa yang tergolong cerdas interpersonal dengan siswa yang tergolong cerdas intrapersonal; 4) sikap nasionalisme siswa menunjukkan perbedaan yang signifikan antara rerata pada siswa yang tergolong cerdas interpersonal dengan siswa yang tergolong cerdas intrapersonal; 5) tidak terdapat interaksi yang signifikan antara metode pembelajaran dan jenis kecerdasan terhadap pengembangan kemampuan berpikir kritis siswa; 6) tidak terdapat interaksi yang signifikan antara metode pembelajaran dan jenis kecerdasan terhadap pengembangan sikap nasionalisme siswa. Kata kunci: problem solving, jenis kecerdasan, berpikir kritis, sikap nasionalisme
Peristiwa Pemberantasan PGRS-Paraku di Kalimantan Barat Tahun 1967
Authors: * Yulita Dewi Purmintasari
Published: February 2020

Penelitian ini bertujuan:mendapatkan informasi yang objektif mengenaiperistiwa pemberantasan PGRS/Paraku di Kalimantan Barat, analisis teori hegemoni Gramsci terhadap peristiwa pemberantasan PGRS/Paraku, pembelajaran sejarah lokal melalui materi peristiwa pemberantasan PGRS/Paraku. Penelitian ini menggunakan metode deskriptif dengan bentuk studi kasus terpancang. Sumber data adalah narasumber dari dosen dan mahasiswa. Teknik pengumpulan data berupa observasi langsung dengan panduan observasi dan komunikasi langsung dengan panduan wawancara.Hasil penelitian menunjukkan: PGRS/Paraku dibentuk ketika terjadi konfrontasi Indonesia-Malaysia. Namun ketika Orde Baru, PGRS/Paraku yang menjadi garda terdepan dalam konfrontasi diperangi. Dalam penumpasan PGRS/Paraku sebagai bentuk kecil hegemoni di Kalimantan Barat, tindakan kekerasan yang bersifat memaksa dilakukan oleh militer, dalam hal ini angkatan darat. Masyarakat Dayak di perbatasan menghimpun kekuatan bersama ABRI melawan komunis yang telah memecah belah mereka dan menumpas PGRS/Paraku.Melalui kajian hegemoni Gramsci, kajian ini dapat menjadi materi pembelajaran sejarah lokal yang perlu dikembangkan untuk menambah pengetahuan serta meningkatkan nasionalisme dan patriotisme generasi mendatang. Kata Kunci : PGRS/Paraku, Hegemoni Gramsci
PENGARUH PENGGUNAAN WAKTU MENONTON TELEVISI, INTERNET, DAN HANDPHONE TERHADAP DISIPLIN BELAJAR SISWA DI LOMBOK
Authors: Tri Hartiti Aliahardi,
Published: February 2020

Penelitian ini bertujuan mengungkapkan pengaruh penggunaan waktu menonton televisi, Internet, dan handphone terhadap disiplin belajar siswa di Desa Kopang, Lombok Tengah. Sumbangan efektif (SE) penggunaan waktu menonton televisi sebesar 43,1%, mengakses Internet sebesar 13,8%,dan mengakses handphone sebesar 0,1% terhadap disiplin belajar siswa. Besarnya sumbangan efektif penggunaan waktu menonton televisi, mengakses Internet, mengakses handphone  terhadap disiplin belajar siswa adalah 57%%, sedangkan sisanya 43% dipengaruhi oleh variabel lain yang tidak dibahas dalam penelitian ini. Dengan demikian pengaruh penggunaan waktu menonton televisi memberikan sumbangan positif paling besar terhadap disiplin belajar siswa. Kata kunci: menonton televisi, mengakses internet, mengakses   handphone dan disiplin belajar
Dramaturgi Mahasiswa Pelaku Hubungan Seksual Di Luar Nikah
Authors: Martiana Aris
Published: February 2020

Fenomena perilaku seksual di luar nikah sangat banyak ditemui di kalangan remaja salah satunya adalah mahasiswa sebagai insan belajar di tingkat pendidikan tinggi sehingga menarik untuk diteliti. Apalagi mereka memiliki prestasi bagus baik secara akademik maupun nonakademik. Permasalahan dalam penelitian ini adalah bagaimana mahasiswa sebagai pelaku hubungan seksual diluar nikah bermain peran. Tujuannya untuk mengetahui mahasiswa pelaku hubungan seksual di luar nikah bermain peran dalam kehidupan masyarakat. Metode yang digunakan adalah kualitatif deskriptif dengan teknik pengumpulan data menggunakan observasi, wawancara dan dokumentasi. Analisis data dilakukan dengan teknik interaktif. Hasil penelitian ini menunjukan bahwa dalam permainan peran informan memiliki wilayah-wilayah sebagai berikut (1). Front Stage, di keluarga dan kampus informan cenderung lebih baik dan sopan dengan menonjolkan atribut keagamaan. (2). Informan tidak membangun jarak yang lebar dengan audien. Mereka memiliki banyak teman tetapi tetap membangun jarak perihal aktivitas seksualnya. (3). Pengelolaan kesan informan yaitu berperilaku lebih sopan dalam penampilan dan aktivitasnya membangun interaksi assosiatif. (4). Terdapat dunia ketiga/dunia luar yang menjadi saksi pertunjukan dan menjaga kerahasiaannya. (5). Jarak peran yang dilakukan informan dengan merasa bersalah dan berdosa terhadap Tuhan, keluarga, dan teman-teman.Kata kunci : Dramaturgi, Mahasiswa , dan Seks Di Luar Nikah
Pengaruh Penerapan Metode VCT (Value Clarification Technique) Terhadap Peningkatkan Partisipasi dan Hasil Belajar Pkn
Authors: * Rakhmawati Khasanah, Suharno
Published: February 2020

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan metode VCT (Value Clarification Technique) terhadap peningkatan partisipasi dan hasil belajar PKn siswa di SMP N 3 Gamping dan SMP N 3 Godean. Penelitian ini merupakan penelitian eksperimen semu atau (Quasi Experiment). Penentuan sampel dalam penelitian ini menggunakan teknik Nonprobability Sampling yaitu Purposive Sampling. Hasil penelitian menunjukkan bahwa pembelajaran PKn dengan menggunakan metode VCT  berpengaruh positif terhadap peningkatan partisipasi dan hasil belajar. Hasil perhitungan diperoleh nilai F=7,116 dan nilai signifikansinya adalah 0,0020,005. Maka terdapat pengaruh secara signifikan pembelajaran dengan menggunakan metode VCT terhadap partisipasi dan hasil belajar siswa, atau terdapat perbedaan partisipasi dan hasil belajar siswa secara signifikan antara siswa kelas eksperimen dan kelas kontrol.Kata kunci: VCT (Value Clarification Tehnique), Partisipasi, Hasil Belajar
Hubungan Antara Pola Asuh Orang Tua dan Kebiasaan Menonton Televisi Pendidikan Dengan Nilai-Nilai Moral
Authors: * Ika Noviana, Aman
Published: February 2020

Penelitian ini bertujuan untuk menguji: (1) hubungan antara pola asuh orang tua dengan nilai-nilai moral, (2) hubungan antara kebiasaan menonton televisi pendidikan dengan nilai-nilai moral, dan (3) hubungan antara pola asuh orang tua dan kebiasaan menonton televisi pendidikan dengan nilai-nilai moral siswa kelas V SD se-Gugus Puren Condongcatur Depok Sleman. Penelitian ini merupakan penelitian kuantitatif noneksperimental. Sampel penelitian yaitu 149 siswa kelas V SD se-Gugus Puren Condongcatur Depok Sleman. Hasil penelitian menunjukkan: (1) Terdapat hubungan yang positif dan signifikan antara pola asuh orang tua dengan nilai-nilai moral yang ditunjukkan dengan r 0,812 rtabel 0,159 dan p 0,05. (2) Terdapat hubungan yang positif dan signifikan antara kebiasaan menonton televisi pendidikan dengan nilai-nilai moral yang ditunjukkan dengan r 0,731 rtabel 0,159 dan p 0,05. (3) Terdapat hubungan yang positif dan signifikan antara pola asuh orang tua dan kebiasaan menonton  televisi pendidikan dengan nilai-nilai moral yang ditunjukkan  dengan r 0,841 rtabel 0,159 dan F 176,828 Ftabel 3,06.Kata kunci: pola asuh orang tua, kebiasaan menonton televisi pendidikan, nilai-nilai moral,
Internalisasi Nilai Karakter Nasionalis dalam Pembelajaran IPS Untuk Membangun Jati Diri Ke-Indonesia-an
Authors: * Utomo, Eko Prasetyo
Published: February 2020

Gejala memudarnya jati diri ke-Indonesia-an dikalangan generasi muda utamanya para pelajar pada tingkat yang mengkhawatirkan seperti tidak mampu  menghafal sila Pancasila, lagu Indonesia Raya, dan Bhinneka Tunggal Ika, hingga  tidak mengerti batas-batas wilayah Indonesia. Fokus penelitian ini adalah menggali proses dan makna internalisasi nilai karakter nasionalis dalam pembelajaran IPS. Penelitian ini menggunakan pendekatan kualitatif dengan desain penelitian fenomenologi. Subjek penelitian adalah siswa SMP Negeri Model Terpadu Bojonegoro dengan menggunakan teknik purposive sampling. Pengumpulan data dilakukan dengan teknik wawancara, observasi, dan kuesioner. Hasil penelitian ini menunjukkan bahwa nilai karakter nasionalis diinternalisasikan dalam tiga tahap yaitu 1) transformasi nilai; 2) transaksi nilai; dan 3) transisternalisasi nilai. Proses internalisasi nilai karakter nasionalis dalam pembelajaran IPS melalui mediator keteladanan guru dan kegiatan praktik langsung pengalaman belajar seperti model pembelajaran, metode pembelajaran, bahan ajar, dan evaluasi pembelajaran. Perilaku berkarakter nasionalis yang diaktualisasikan dalam kehidupan sehari-hari di sekolah oleh siswa yaitu disiplin, cinta tanah air, semangat kebangsaan, cinta damai, peduli lingkungan, menghargai prestasi, dan toleransi.Kata kunci: Internalisasi, Nasionalis, IPS, Jati diri ke-Indonesia-an
An overview of synthetic biology
Authors: Belén Paredes Maria , Eugenia Sulen Maria
Published: February 2020

Synthetic Biology is the combination of basic sciences with engineering. The aim of Synthetic Biology is to create, design, and redesign biological systems and devices to understand biological processes and to achieve useful and sophisticated functionalities to improve human welfare. When the engineering community took part in the discussion for the definition of Synthetic Biology, the idea of extraction and reassembly of “biological parts” along with the principles of abstraction, modularity, and standardization was introduced. Genetic Engineering is one of the many essential tools for synthetic biology, and even though they share the DNA manipulation basis and approach to intervene in the complexity of molecular biology, they differ in many aspects, and the two terms should not be used interchangeably. Some of the applications that have already been done by Synthetic Biology include the production of 1,4-butanediol (BDO), the antimalarial drug artemisinin, and the anticancer compound taxol. The potential of Synthetic Biology to design new genomes without immediate biological ancestry has raised ontological, political, economic, and ethical concerns based on the possibility that synthetic biology may be intrinsically unethical.