bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND): Protocol for a Prospective Study
Authors: Diepstraten Franciscus A , Meijer Annelot JM , van Grotel Martine , Plasschaert Sabine LA , Hoetink Alexander E , Fiocco Marta , Janssens Geert O , Stokroos Robert J , van den Heuvel-Eibrink Marry M
Published: February 2022

Background

Some children with central nervous system (CNS) and solid tumors are at risk to develop ototoxicity during treatment. Up to now, several risk factors have been identified that may contribute to ototoxicity, such as platinum derivates, cranial irradiation, and brain surgery. Comedication, like antibiotics and diuretics, is known to enhance ototoxicity, but their independent influence has not been investigated in childhood cancer patients. Recommendations for hearing loss screening are missing or vary highly across treatment protocols. Additionally, adherence to existing screening guidelines is not always optimal. Currently, knowledge is lacking on the prevalence of ototoxicity.

Objective

The aim of the Study on Prevalence and Determinants of Ototoxicity During Treatment of Childhood Cancer (SOUND) is to determine the feasibility of audiological testing and to determine the prevalence and determinants of ototoxicity during treatment for childhood cancer in a national cohort of patients with solid and CNS tumors.

Methods

The SOUND study is a prospective cohort study in the national childhood cancer center in the Netherlands. The study aims to include all children aged 0 to 19 years with a newly diagnosed CNS or solid tumor. Part of these patients will get audiological examination as part of their standard of care (stratum 1). Patients in which audiological examination is not the standard of care will be invited for inclusion in stratum 2. Age-dependent audiological assessments will be pursued before the start of treatment and within 3 months after the end of treatment. Apart from hearing loss, we will investigate the feasibility to screen patients for tinnitus and vertigo prevalence after cancer treatment. This study will also determine the independent contribution of antibiotics and diuretics on ototoxicity.

Results

This study was approved by the Medical Research Ethics Committee Utrecht (Identifier 20-417/M). Currently, we are in the process of recruitment for this study.

Conclusions

The SOUND study will raise awareness about the presence of ototoxicity during the treatment of children with CNS or solid tumors. It will give insight into the prevalence and independent clinical and cotreatment-related determinants of ototoxicity. This is important for the identification of future high-risk patients. Thereby, the study will provide a basis for the selection of patients who will benefit from innovative otoprotective intervention trials during childhood cancer treatment that are currently being prepared.

Trial Registration

Netherlands Trial Register NL8881; https://www.trialregister.nl/trial/8881

International Registered Report Identifier (IRRID)

DERR1-10.2196/34297
Perceptions on the Use of Wearable Sensors and Continuous Monitoring in Surgical Patients: Interview Study Among Surgical Staff (Preprint)
Authors: Joshi Meera , Archer Stephanie , Morbi Abigail , Ashrafian Hutan , Arora Sonal , Khan Sadia , Cooke Graham , Darzi Ara
Published: February 2022

BACKGROUND

Continuous vital sign monitoring by using wearable sensors may result in the earlier detection of patient deterioration and sepsis. Few studies have explored the perspectives of surgical team members on the use of such sensors in surgical patients.

OBJECTIVE

This study aims to understand the views of surgical team members regarding novel wearable sensors for surgical patients.

METHODS

Wearable sensors that monitor vital signs (heart rate, respiratory rate, and temperature) continuously were used by acute surgical patients. The opinions of surgical staff who were treating patients with these sensors were collated through in-depth semistructured interviews to thematic saturation. Interviews were audio recorded, transcribed, and analyzed via thematic analysis.

RESULTS

A total of 48 interviews were performed with senior and junior surgeons and senior and junior nurses. The main themes of interest that emerged from the interviews were (1) problems with current monitoring, (2) the anticipated impact of wearables on patient safety, (3) the impact on staff, (4) the impact on patients overall, (5) potential new changes, and (6) the future and views on technology.

CONCLUSIONS

Overall, the feedback from staff who were continuously monitoring surgical patients via wearable sensors was positive, and relatively few concerns were raised. Surgical staff members identify problems with current monitoring and anticipate that sensors will both improve patient safety and be the future of monitoring.
Effectiveness of a new smartphone application on type 1 diabetes control and self-management in times of Covid-19: Prospective comparative study (Preprint)
Authors: Derkaoui Nada , Benyakhlef Salma , Rami Imane , Elmehraoui Ouafae , Charif Hajar , Messaoudi Najoua , Bouichrat Nisrine , Assarrar Imane , Tahri Abir , Derbel Salma , Abda Naima , Rouf Siham , Latrech Hanane
Published: February 2022

BACKGROUND

Background: Self-management for type 1 diabetes mellitus patients is a real challenge especially in a time of a spreading pandemic. “Ana wa Soukari” is a newly designed smartphone application for therapeutic education and insulin doses management. 

OBJECTIVE

Objectives: Our study evaluated the effectiveness of “Ana wa Soukari” on clinical and biological outcomes of type 1 diabetes self-management. 

METHODS

Methods: This is a prospective comparative study including 62 patients. Primary study endpoint was HbA1c after three months’ follow-up. Secondary study endpoints were number of hypoglycaemic events and diabetes treatment satisfaction. Treatment satisfaction was assessed using the Arabic version of DTSQs questionnaire. 

RESULTS

Results: Sixty-two patients were included in our study. The mean age of our patients was 15 6,41 years. Sex ratio M/F = 1,1. Mean diabetes duration was 4,9 4,3 years and 67,7% of patients had diabetes for less than 5 years. Mean HbA1c levels in Group A (with application) and Group B (without application) dropped from 8,3% 2,3 and 8,2% 2 respectively at baseline to 7,4% 1,5 and 8% 1,8 at three months’ follow-up. Change in hypoglycaemic episodes was – 1,8 2,0 (P < 0,001) for Group A and – 1,2 1,5 (P < 0,001) for Group B. DTSQs was performed in both groups at end point. Scores were significantly higher in group (A) than in group (B) with a mean score of 31,8 3,4 and 28,4 3,8 respectively (P < 0,001). 

CONCLUSIONS

Conclusions: Self-management smartphone apps appear to be effective on glycaemic control and should be considered as an adjuvant intervention to the standard diabetes care. 

CLINICALTRIAL
The effects of an exergame implemented in primary schools on physical activity, sedentary time and motivation in children (Preprint)
Authors: ten Velde Gabrielle
Published: February 2022

BACKGROUND

The majority of children are insufficiently physically active. The interest in video games amongst children provides new opportunities to increase physical activity (PA) via exergames. Tailoring exergames is costly and labor intensive and therefore the implementation of an exergame with minimal support could be promising. The exergame BOOSTH uses a wrist worn activity tracker to measure steps per day. As a reward for the performed PA, children can unlock levels in the online BOOSTH game. In addition, the BOOSTH battle enables competition between groups.

OBJECTIVE

The current study aims to investigate the effect of the exergame BOOSTH, implemented in the primary school setting, on PA, sedentary time (ST), screen time and motivation towards PA after three and six months.

METHODS

The study was a cluster randomized controlled trial. Stratified by community and school size, sixteen primary schools were randomized into standard physical education curriculum (control) or standard physical education curriculum + BOOSTH (intervention). Measurements were performed at baseline and after 3 and 6 months. PA (total PA, light PA and moderate to vigorous PA (MVPA)) and ST were measured with the GT3X Actigraph accelerometer and the BAECKE questionnaire. Motivation towards PA was measured with the BREQ-2 questionnaire. Data were analyzed using linear mixed models.

RESULTS

710 children (53% girls, 10 ± 1y of age) participated in this study. After correction for baseline levels/data, children in the intervention group had on average a lower MVPA (min/day) (effect estimate B= -10, p= <0.001) and higher ST (min/day) (B= 24, p= 0.002) at six months compared to the control group. After six months, children in the intervention group reported lower intrinsic motivation towards PA (B= 0.27, p = 0.011) and higher screen time on a weekday (B= 0.033, p = 0.045) compared to the intervention group. Sensitivity analyses showed similar results.

CONCLUSIONS

Implementation of the exergame BOOSTH in the primary school setting had adverse effects on promoting PA and reducing ST in daily life of children in the first half year. A mixed method process evaluation is needed to gain a more complete understanding of the (un)successful implementation components, and to identify recommendations for future exergame interventions in
the school setting.

CLINICALTRIAL

ClinicalTrials.gov, NCT03440580, https://clinicaltrials.gov/ct2/show/NCT03440580.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/24035
Adaptive Text Messaging for Postpartum Risky Drinking: Conceptual Model and Protocol for an Ecological Momentary Assessment Study (Preprint)
Authors: Dauber Sarah , Beacham Alexa , Hammond Cori , West Allison , Thrul Johannes
Published: February 2022

BACKGROUND

Risky drinking is prevalent among women of childbearing age. Although many women reduce their drinking during pregnancy, more than half return to prepregnancy levels during the early postpartum period. Risky drinking in new mothers may be associated with negative child and maternal health outcomes; however, new mothers are unlikely to seek treatment for risky drinking because of stigma and fear of child protective service involvement. SMS text messaging is a promising approach for reaching non–treatment-seeking new mothers at risk because of risky drinking. SMS text messaging interventions (TMIs) are empirically supported for alcohol use, but a tailored intervention for new mothers does not exist. This study aims to fill this gap by developing a just-in-time adaptive TMI for postpartum risky drinking.

OBJECTIVE

The objectives of this paper are to present a preliminary conceptual model of postpartum risky drinking and describe the protocol for conducting an ecological momentary assessment (EMA) study with new mothers to inform the refinement of the conceptual model and development of the TMI.

METHODS

This paper presents a preliminary conceptual model of postpartum risky drinking based on the motivational model of alcohol use, social cognitive theory, and temporal self-regulation theory. The model proposes three primary intervention targets: motivation, self-efficacy, and self-regulation. Theoretical and empirical literature in support of the conceptual model is described. The paper also describes procedures for a study that will collect EMA data from 30 participants recruited via social media and the perinatal Central Intake system of New Jersey. Following the baseline assessment, EMA surveys will be sent 5 times per day for 14 days. The assessment instruments and data analysis procedures are described.

RESULTS

Recruitment is scheduled to begin in January 2022 and is anticipated to conclude in March 2022. Study results are estimated to be published in July 2022.

CONCLUSIONS

The study findings will enhance our understanding of daily and momentary fluctuations in risk and protective factors for risky drinking during the early postpartum period. The findings will be used to refine the conceptual model and inform the development of the TMI. The next steps for this work include the development of intervention components via an iterative participatory design process and testing of the resulting intervention in a pilot microrandomized trial.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/36849
In-hospital enrollment into an electronic patient portal results in improved follow-up after orthopedic surgery (Preprint)
Authors: Bhashyam Abhiram R. , Bansal Mira , McGovern Madeline M. , van der Vliet Quirine MJ , Heng Marilyn
Published: February 2022

BACKGROUND

Electronic patient portal (EPP) use is associated with lower no-show rates and increased patient satisfaction. However, there are disparities in enrollment into these communication platforms.

OBJECTIVE

We hypothesized that guided inpatient enrollment into an EPP would improve clinical follow-up and EPP use rates for orthopaedic surgery patients compared to the usual practice of providing information in the discharge summary.

METHODS

We performed a randomized controlled trial of 229 adult patients who were admitted to the hospital for an orthopedic condition that required a three-month follow-up visit. Patients were cluster randomized by week to either the control or intervention group. The control received information on how to enroll into and use the EPP in their discharge paperwork, while the intervention was actively enrolled and taught. At 3 months post-discharge, patients were followed to see if they attended their follow-up appointment or used the EPP.

RESULTS

83% of patients presented for follow-up at 3 months (80.2 vs 85.8, control vs intervention, P=0.25). Likelihood of EPP use was significantly higher in the intervention group (16.4% vs 62.0%; OR 8.3, 95% confidence interval = 4.5, 15.5; P<0.001). Intervention patients who used the EPP were more likely to present for post-surgical follow-up (OR 3.59, 95% confidence interval = 1.28, 10.06; P = 0.015).

CONCLUSIONS

Inpatient enrollment of orthopaedic surgery patients into an EPP increased EPP use, but this did not independently result in enhanced follow-up. Patients who were enrolled as inpatients and subsequently used the portal had the highest likelihood of 3-month follow-up.

CLINICALTRIAL

Registry Name
ClinicalTrials.gov
Registry Number
NCT03431259
Synthesis of SO42–/ZrO2 Solid Acid and Na2O/ZrO2 Solid Base Catalysts Using Hydrothermal Method for Biodiesel Production from Low-Grade Crude Palm Oil
Authors: Setyaningsih Sri , Utami Maisari , Syoufian Akhmad , Heraldy Eddy , Yuwono Nasih Widya , Wijaya Karna
Published: February 2022

Biodiesel is a renewable energy source that can be produced through esterification as well as transesterification reactions. This work presents a series of zirconia catalysts synthesized by hydrothermal method on various concentrations in acidic (H2SO4 0.3, 0.5, and 0.7 M) and basic (NaOH 1, 2, 3, and 4 M) solution to get a catalyst with the highest acidity or basicity. Characterizations of the catalysts were performed by FTIR, XRD, SEM-EDX, surface area analysis, acidity, and basicity test. The most active acid catalyst activity was evaluated for the esterification of low-grade crude palm oil (LGCPO), while the solid base catalyst was utilized for the transesterification reaction. The solid acid catalyst of 0.7 M SO42–/ZrO2 60 °C; 24 h was denoted as the most active acid catalyst with a total acidity of 1.86 mmol g–1, while 4 M Na2O/ZrO2 60 °C; 24 h catalyst was considered as the solid base catalyst with the highest total basicity of 3.75 ± 0.12 mmol g–1. The optimized acid catalyst exhibited a 31 times higher acidity than commercial ZrO2. The concentration of free fatty acids (FFA) decreased to 68.87% in the esterification reaction. The solid base catalyst of 4 M Na2O/ZrO2 60 °C; 24 h successfully converted LGCPO into biodiesel by 68.55% through a transesterification reaction.
On the Mechanical and Thermal Properties of Poly(Vinyl Alcohol) – Alginate Composite Yarn Reinforced with Nanocellulose from Oil Palm Empty Fruit Bunches
Authors: Maghfirah Ainul , Fahma Farah , Lisdayana Nurmalisa , Yunus Muchammad , Kusumaatmaja Ahmad , Kadja Grandprix Thomryes Marth
Published: February 2022

PVA-alginate hydrogel is a promising material for use in biomedical applications due to its desirable characteristics: biocompatible, durable, non-toxic, and low cost. However, the low gel strength of this composite limits its use in biomedical applications. This study aims to develop enhanced mechanical and thermal properties of poly(vinyl alcohol) PVA-alginate composite yarn by adding nanocellulose isolated from the sustainable oil palm empty fruit bunches (OPEFBs). The PVA-alginate composite yarns reinforced with nanocellulose were prepared with various nanocellulose contents (1 wt.%, 2 wt.%, and 5 wt.%). The composite's tensile strength exhibited an increasing trend with the addition of nanocellulose, while the elongation at break showed the opposite trend. Moreover, it was demonstrated that the composite's thermal degradation shifts to higher temperatures with the addition of nanocellulose. The observed activation energies for the thermal degradation calculated using the Coats-Redfern method exhibited a significant increment for the composites reinforced with nanocellulose. These results show that the addition of nanocellulose into the PVA-alginate matrix enhances the chemical and thermal properties of the resulting hydrogel. All these improvements have resulted from more abundant and robust hydrogen bonds generated by the nanocellulose presence.
Simple One-Pot Synthesis of Sulfonic-Acid-Functionalized Silica for Effective Catalytic Esterification of Levulinic Acid
Authors: Ristiana Desinta Dwi , Suyanta Suyanta , Nuryono Nuryono
Published: February 2022

Silica functionalized with sulfonic acid catalyst (SiO2−SO3H) was synthesized through a one-pot method and evaluated as the catalyst material for esterification of levulinic acid in an excess amount of ethanol. Sodium silicate solution was used as the silica source, and then a silane coupling agent, namely GPTMS, was used to incorporate the sulfonic group of 2-aminoethanesulfonic acid (AS) into the silica. Functionalization of AS using GPTMS in the slightly acidic condition has been successfully carried out based on the characterization with FTIR, SEM-EDX, and TGA measurements. Catalyst with the AS to SiO2 molar ratio of 5:6 (SiO2−SO3H(5)) showed the highest acid content (1.02 mmol g–1) and the highest conversion of levulinic acid (70%). The reaction followed pseudo-first-order with the rate constant of 0.00414 min–1. Catalyst material was regenerated by washing with alcohol and water, and the catalyst material can be reused at least for 3 cycles. From this study, the SiO2−SO3H produced from a green process is an effective catalyst to produce esters used in fuel additives.
Growth, Electronic Structure, and Electrochemical Properties of Cubic BaTiO3 Synthesized by Low-Pressure Hydrothermal-Assisted Sintering
Authors: Khotib Mohammad , Soegijono Bambang , Mas'ud Zainal Alim , Nadjamoeddin Gina Libria
Published: February 2022

Cubic BaTiO3 was synthesized through low-pressure hydrothermal-assisted sintering using Ba(OH)2 and TiO2 as precursors with a mol ratio of Ba:Ti = 1.4:1. The single phase of cubic BaTiO3 was produced at a sintering temperature of 800 °C for 2, 4, 8, and 12 h. The absence of diffraction peak splitting at 2q of 45° was indicated cubic BaTiO3. The crystallite size of BaTiO3 ranged from 80–200 nm, and its size increased with increasing temperatures and sintering times. The micro-strain of the BaTiO3 crystal lattice had a range between 0.27 and 0.68%. The minimum bandgap on the indirect bandgap was about 1.75 eV from point M to Γ, while the direct bandgap was about 1.95 eV from Γ to Γ. Ti–O's interaction had a covalent character, while that of Ba–O had an ionic character based on the density of state (DOS) calculation. The characteristics of the BaTiO3 voltammogram show an irreversible redox mechanism with a more observable reduction peak in Ti4+/Ti3+. Higher current density at over potential indicated greater BaTiO3 capabilities in Oxygen Evolution Reaction (OER)-Oxygen Reduction Reaction (ORR) electrocatalysis. For that, purified cubic BaTiO3 offers potential application as an electrode for batteries, water splitting systems, and regenerative fuel cells.
Una aventura didáctica por internet
Authors: Simón Ruiz Cristina
Published: February 2022

Cuando el año pasado la profesora Emma Jiménez me invitó a participar en esta aventura, acepté casi de inmediato, aunque algunas dudas sobre los resultados que obtendríamos me atenazaban los nervios.

La idea original era poner en contacto, vía intemet, a mis estudiantes de redacción en español, segunda lengua (L2), nivel III, con los estudiantes de la profesora Emma para que compartieran parte de su proceso de adquisición y reflexionaran sobre él, sobre todo en lo que respecta a las diferencias entre adquirir una L2 y una lengua extranjera (L3). Sin embargo, sufrimos una primera decepción, pues mis estudiantes, aduciendo sobre todo el hecho de no tener un acceso personal a la red en México, rechazaron la invitación.

Entonces, surgió la idea de virar nuestros planteamientos iniciales y poner en contacto a los alumnos del curso de Formación de Profesores de Español como L2 LE con los estudiantes canadienses y, adelantándome a las conclusiones, puedo decir que los resultados son alentadores.

En primer lugar, hay que aclarar que los objetivos iniciales cambiaron, obviamente. Lo que decidimos lograr fue, por una parte, que los futuros profesores de español como L2/E empezaran a reflexionar sobre los problemas de adquisición del español como LE por un grupo de alumnos bastante homogéneo y con una misma lengua materna: el francés. Por otra parte, pretendíamos que los alumnos canadienses establecieran un contacto directo con hispanohablantes que no fueran sus profesoras de español y, a través de un contacto directo y personal, tuvieran la oportunidad de reflexionar sobre algunos de sus problemas con la adquisición del español, tanto en el plano gramatical como en el sociocultural.
Representación y reelección legislativa en México: la elección federal de 2021
Authors: Valencia Escamilla Laura
Published: February 2022

El artículo tiene por objetivo analizar el ejercicio de reelección legislativa en las elecciones de 2021 a partir de la eliminación de la prohibición consecutiva bajo dos criterios: a) la reelección como derecho y b) como componente de la profesionalización parlamentaria. Para ello, se propone revisar el desarrollo del paso de la reincidencia a la reelección como cambio institucional, así como identificar el efecto que dicho cambio tiene en las carreras legislativas de los representantes populares desde un punto de vista cíclico y de continuidad en los intereses de los diputados federales que se reeligen por primera vez en las elecciones de 2021, por lo cual se elaboró una base de datos que acumula información de las trayectorias de los legisladores mexicanos en función de su experiencia en distintos puestos de representación y de la administración pública local y federal.
Las elecciones federales 2021 en México: ¿plebiscitarias o identitarias?
Authors: Moreno Álvarez Alejandro
Published: February 2022

Las elecciones de 2021 en México podrían describirse como plebiscitarias, como suelen verse las elecciones intermedias en el país,  y más aún porque la aprobación de gobierno fue la variable de mayor peso en el voto, según indican los datos de una encuesta nacional de salida entre votantes. La aprobación presidencial superó en ese año a otras variables que usualmente ejercen un efecto muy significativo en el sufragio, como la identificación partidista o la identidad ideológica, lo cual sugiere que se trató de una elección en la que la evaluación del desempeño gubernamental fue fundamental. Sin embargo, la categorización como elección plebiscitaria depende del significado que atribuyamos a la aprobación presidencial. En este artículo analizamos no solamente el papel que jugó la aprobación al presidente en el voto, sino qué factores nos ayudan a entender esa variable. El resultado es que la aprobación presidencial efectivamente contiene elementos de evaluación ciudadana al quehacer gubernamental, pero también tiene componentes identitarios muy importantes que no necesariamente implican un indicador de performance o desempeño, sino de empatía y de apego identitario grupal. Esta conclusión nos invita a reflexionar sobre el carácter plebiscitario o identitario no solamente del voto en 2021, sino a repensar lo que hasta ahora la literatura sobre comportamiento electoral ha dado por sentado: el carácter evaluativo de la aprobación presidencial.
Characteristics of Fuzzy Petersen Graph and Platonic Graph with Fuzzy Rule
Authors: R Suguna.
Published: February 2022

Abstract: Graph theory is the concepts used to study and model various application in different areas. In this paper, we consider the The Petersen and also the Platonic graph using if-then-rules fuzzy numbers. The results are related to the find the degree of odd vertices and even verticesare same by applying if-then-rules through the paths described by fuzzy numbers. Keywords: Degree of Vetex, Incident Graph, Peterson Graph, Platonic graph, Fuzzy IF-THEN rule.
Corrosion Inhibition of Mild Steel in Different Acid Medium by Using Various Acidic Groups of Organic Compounds
Authors: Ade Suraj B.
Published: February 2022

Abstract: Benzoic acid, salicylic acid, Anthranilic acid, 2- Nitro benzoic acid, 2- Chlorobenzoic acid compounds containing acidic group as a corrosion inhibitor for carbon steel was investigated. The study revealed that the various group such as (- COOH, OH, Cl and –NO2) containing in organic compounds has an inhibitory action on the corrosion of carbon steel in the investigated medium. Corrosion rate of mild steel was studied using chemical weight loss method at room temperature. This research paper presents use of carboxylic group organic compounds as corrosion inhibitors for metals in 0.1N, 0.01N and 0.001N (HCl, HNO3 and H2SO4) acidic medium. A common mechanism for inhibiting corrosion involves formation of a coating, often a passivation layer, which prevents access of the corrosive substance to the metal. Organic corrosion inhibitors adsorb on the surface to form protective film, which displace water and protect it against deteriorating. Effective organic corrosion inhibitors contain nitrogen, oxygen, sulphur and phosphorus with lone electron pairs as well can contain structural moieties with π-electrons that interact with metal favouring the adsorption process. This review presents mechanisms and monitoring of corrosion, laboratory methods for corrosion study, relationship between structure and efficacy of corrosion inhibitions, theoretical approach to design new inhibitors and some aspects of corrosion. Keywords: Corrosion, Inhibition, carbon steel, Weight loss and acidic group (-COOH, OH, -Cl and –NO2) group containing organic compounds.
Efecto de la aplicación intrauterina de ozono sobre la migración de neutrófilos y la endometritis subclínica en ganado lechero
Authors: González-Aguado Jessica Bárbara , Ochoa-Estrada Elisa , Vera-Ávila Hector Raymundo , Chávez-López Ma. De Jesús , Espinosa-Martínez Mario Alfredo , Cantó-Alarcón Germinal Jorge , Gutiérrez-García Claudia , Montiel-Olguín Luis Javier
Published: February 2022

El objetivo fue determinar si una solución salina ozonizada (SSO3) incrementa los neutrófilos polimorfonucleares (NPMN) endometriales (Exp 1) y desafiar el efecto preventivo de SSO3 sobre la endometritis subclínica (ESC) (Exp 2). En el Exp 1 se utilizaron 38 vacas Holstein primíparas. Se incluyeron vacas con (CAM) y sin antecedentes de metritis postparto (SAM); posteriormente se repartieron en subgrupos control (CTRL, solución salina) o SSO3 (6.7 ± 0.3 ppm). A los 55 días postparto se aplicó 50 ml de CTRL o SSO3 intrauterinamente y a las 48 h se registró la cantidad de NPMN por citología endometrial. En el Exp 2 se utilizaron 26 vacas Holstein primíparas SAM. Las vacas se repartieron aleatoriamente en CTRL o SSO3. Se administraron dos dosis de 50 ml con intervalo de 7 días (primera aplicación 11.3 ± 0.4 días postparto). Al día 30 postparto se diagnosticó ESC (≥6% NPMN). Las vacas CAM tuvieron mayor número de NPMN endometriales comparado con vacas SAM (13.9 ± 6.2 vs 1.0±0.46, P<0.05). El grupo CAM-CTRL presentó mayor número de NPMN que el SAM-CTRL (17.0 ± 9.6 vs 0.1 ± 0.1, P<0.05) mientras que los grupos CAM-SSO3 y SAM-SSO3 (10.4 ± 8.1 vs 1.8±4.8, P>0.05) y SAM-CTRL y SAM-SSO3 (0.1 ± 0.1 y 1.8 ± 4.8, P>0.05) no fueron diferentes. Se observó una tendencia estadística (P=0.09) de menor porcentaje de ESC en grupo CTRL comparado con SSO3 (15.4 y 46.2 %, respectivamente). En conclusión, la SSO3 por vía transcervical no incrementa el número de NPMN endometriales y el tratamiento preventivo con SSO3 aplicado a vacas SAM no disminuyó la ESC. Los resultados sugieren un posible efecto antiinflamatorio del tratamiento solución salina ionizada.
NUMBER DISTRIBUTION AND RESONANCE
Authors: Dombrovsky K. , Stanyukovich K.
Published: February 2022

The article discusses the relationship between the periods of oscillation of physical systems with the problem of distribution of rational numbers on the number axis. The representation of numbers by continued fractions is also considered. Particular attention is paid to the physical consequences of the ratios of the periods of oscillations, such as the connection of the “golden section” with the law of distribution of planetary distances, the connection of the laws of information transmission processes with the sensitivity of the human eye realized in nature.
EXPERIMENTAL INVESTIGATIONS ON IDENTIFICATION OF A PRIORI RELATIONSHIP ОF 4-DIMENSION EVENTS AND ITS PROPERTIES
Authors: Eganova I. A , Kallies W.
Published: February 2022

In this article the method of astronomical observations, which makes it possible to obtain a direct experimental answer to key questions about the physical properties of space-time is considered. The initiating effect to external irreversible processes, which underlines this method and is the action of ‘causal relationships’ - the a priori relationship of simultaneous four-dimensional events, and related experimental investigations are discussed.
SOME PRACTICAL CONSIDERATIONS TO THE SOLVING OF THEORETICAL PHYSICS PROBLEMS
Authors: Shershakov Ye. P
Published: February 2022

The philosophical and historical review of the emergence of new metaphysical and worldview provisions is made. New approaches to solving urgent problems in modern science could appear on this basis. The main provisions of as an example of a new approach and using the original mathematical apparatus are given. Methods can be fruitful in obtaining new results in modern physics are described. Some suggestions about the presence of a sunset high “collective organization” that can systematize the behavior of systems regardless of their nature origin (physical, chemical, biological, social, economic, etc.) are made.
La transferencia del conocimiento y las capacidades de medición y calibración en laboratorios nacionales de metrología
Authors: Castro-Galván Esther , Cázares-Garrido Ilia Violeta
Published: February 2022

El proceso de declaración de las capacidades de medición y calibración implica que de forma continua los laboratorios nacionales de metrología se actualicen en temas nuevos, participen en comparaciones internacionales para demostrar sus capacidades técnicas e implementen nuevos servicios de medición derivados de las comparaciones. La capacidad de absorción de una organización, en el contexto de las capacidades dinámicas, es la habilidad para identificar el valor de un nuevo conocimiento exterior, asimilarlo y convertirlo en un producto comercial. Esta capacidad de absorción es un mecanismo interno de una organización para poder evaluar cuánto del conocimiento externo es capaz de asimilar dados sus conocimientos internos. El objetivo de este estudio se centra en evaluar la posible conexión de las capacidades de medición y calibración con el desarrollo de nuevos servicios de calibración para proponerlos como indicadores de la transferencia del conocimiento y de la capacidad de absorción de los laboratorios nacionales de metrología. Se estudiaron tres laboratorios nacionales de México, Brasil y Argentina, para un análisis descriptivo del número total de CMC en el periodo de 2001 a 2020, utilizando la base de datos de la oficina internacional de pesas y medidas. Debido al escaso número de datos públicos, solo para México se relacionaron las capacidades declaradas con sus servicios de medición, así como la posible relación de crecimiento de nuevos clientes. Se encontró que el proceso de declaración de capacidades de medición y calibración es continuo y se relaciona directamente con la creación de nuevos servicios de medición y de nuevos clientes, por lo que se propone como un indicador de transferencia del conocimiento de la organización. Sin embargo, es necesario buscar más información empírica en un análisis posterior a profundidad debido a que actualmente no se han encontrado investigaciones que estudien este proceso sistemáticamente.
Konstruksi Perangkat Pembelajaran Model Levels of Inquiry disertai Socio-Scientific Issues untuk Keterampilan Pemecahan Masalah
Authors: Afandi Afandi , Titin Titin , Setyawati Yuyun
Published: February 2022

This study to analyze the need for problem solving skills of class X SMA Muhammadiyah 1 Pontianak, develop learning tools on ecosystem materials, and determine the validity and reliability of learning device. The research method used is Thiagarajan et al. The learning tools developed consisted of 6 lesson plans and 6 student worksheets based on the levels of inquiry accompanied by socio-scientific issues, handout, power point, and evaluation question. The results obtained were the validity of 6 lesson plans and 6 student worksheet, handout, power point, and evaluation question, namely v ≥ 0,8 (valid). The result of interrater reliability was using ICC on 5 lesson plans and 5 student worksheets, power point are 0,75-0,9 (good). While the reliability on 1 lesson plan and 1 student worksheets, handout, and evaluation question got a value of 0,5-0,75 (moderate). Developed learning tools were asserted worthy to use.
Abstrak. Penelitian ini bertujuan untuk menganalisis kebutuhan keterampilan pemecahan masalah siswa kelas X SMA Muhammadiyah 1 Pontianak, mengembangkan perangkat pembelajaran pada materi ekosistem, dan mengetahui validitas serta reliabilitas perangkat pembelajaran. Metode penelitian yang digunakan adalah Research and Development (R&D) mengacu pada model Four-D yang dikemukakan oleh Thiagarajan, dkk. Perangkat pembelajaran yang dikembangkan terdiri dari 6 buah RPP dan 6 buah LKPD berdasarkan tingkatan model levels of inquiry disertai socio-scientific issues, handout, power point, dan soal evaluasi. Diperoleh hasil validitas 6 buah RPP dan 6 buah LKPD, handout, power point, dan soal evaluasi yaitu v ≥ 0,8 (valid). Hasil reliabilitas antar rater menggunakan ICC pada 5 buah RPP dan 5 buah LKPD, media pembelajaran yaitu 0,75-0,9 (baik). Sedangkan reliabilitas pada 1 buah RPP dan 1 buah LKPD, handout, dan soal evaluasi mendapatkan nilai 0,5-0,75 (sedang). Perangkat pembelajaran yang dikembangkan dinyatakan layak untuk digunakan.
Pengembangan E-Modul Sigil Software Untuk Meningkatkan Hasil Belajar Siswa Di Masa Pandemi Covid-19
Authors: Munandar Rifki Risma , Cahyani Rusdianti , Fadilah Eva
Published: February 2022

Learning activities are currently carried out online from home in order to prevent the spread of Covid-19. Appropriate learning alternatives are needed for students in times of pandemics. The purpose of this research is to develop e-modules of ecosystem materials that are expected to support the improvement of student learning outcomes during the Covid-19 pandemic. This research was conducted in January-July 2021 using the Research and Development (R&D) method in the ADDIE model. The client's goal of the product was tested on a limited basis to 27 class X students. The instruments used in this study are media feasibility validation sheets, learning outcome tests to measure the effectiveness of e-modules and questionnaires of student responses to developed media. The results showed that E-modules that have been developed and validated by experts get a very decent category as a learning medium with a value of 92.85% and e-modules developed can improve student learning outcomes. The conclusion obtained that the e-modules developed are feasible and effectively used as teaching materials to help students in the learning process.
Abstrak. Kegiatan pembelajaran pada saat ini dilaksanakan secara daring dari rumah dalam rangka pencegahan penyebaran Covid-19. Dibutuhkan alternatif pembelajaran yang tepat bagi siswa di masa pandemi. Tujuan penelitian ini yaitu mengembangkan bahan ajar e-modul materi ekosistem yang diharapkan  dapat menunjang peningkatkan hasil belajar siswa disaat pandemi Covid-19. Penelitian ini dilaksanakan pada bulan Januari-Juli 2021 dengan menggunakan metode Research and Development (R&D) menggunakan model ADDIE. Sasaran klien dari produk hasil penelitian ini diujicobakan secara terbatas kepada siswa kelas X dengan jumlah 27 orang. Instrument yang digunakan dalam penelitian ini berupa lembar validasi kelayakan media, tes hasil belajar untuk mengukur efektivitas e-modul dan angket respon siswa terhadap media yang dikembangkan. Hasil penelitian menunjukkan bahwa E-modul yang telah dikembangkan dan divalidasi oleh ahli mendapat kategori sangat layak sebagai media pembelajaran dengan nilai 92,85% dan e-modul yang dikembangkan dapat meningkatkan hasil belajar siswa. Kesimpulan yang didapat bahwa e-modul yang dikembangkan layak dan efektif digunakan sebagai bahan ajar untuk membantu siswa dalam proses pembelajaran.
o lazer e a pessoa com deficiência física usuária de cadeira de rodas
Authors: Beltrame André Luís Normanton
Published: February 2022

Este estudo tem como objetivo responder à seguinte pergunta: em que perspectiva se inscreve a participação social no lazer de adultos com deficiência física usuários de cadeira de rodas em cenários de microparticipação social? Para tanto, a pesquisa se envolveu com três grupos dedicados a pessoas com deficiência procurando reconhecer a configuração da participação social em termos de condições, dinâmicas e ferramentas operativas em seu universo de ação. De metodologia qualitativa e abordagem hermenêutico-dialética foram acompanhados vinte e um atores sociais e seus grupos. Os resultados apontam para condições de estrutura de poder e conflito em desfavor da pessoa com deficiência. Nota-se que as dinâmicas dos grupos os apontam capazes de favorecer a informação e a organização, porém de forma mais afetiva que instrumental. Conclui-se na necessidade de avançar em pressupostos educativos no interior dos grupos que deem conta da estrutura de poder vigente.
dupla carreira acadêmico-esportiva na América Latina entre os anos 2000 e 2020
Authors: Ricci Christiano Streb , Aquino Rodrigo , Marques Renato Francisco Rodrigues
Published: February 2022

O presente estudo analisou a produção científica sobre dupla carreira acadêmico-esportiva em artigos oriundos da América Latina publicados em periódicos acadêmicos entre os anos 2000 e 2020. A seleção e análise dos artigos seguiram os métodos/protocolo ENTREQ, Análise Temática Reflexiva e Análise de Redes Sociais. Oito bases de dados foram pesquisadas e 39 artigos selecionados. Os resultados indicam: a) os primeiros trabalhos encontrados datam de 2011; b) os estudos se concentram principalmente no Brasil; c) a interação entre pesquisadores latino-americanos é pequena; d) predominam as abordagens qualitativas; e) as categorias de base e a Educação Básica são os contextos mais investigados; f) predominam estudos com modalidades esportivas praticadas por homens, especialmente o futebol. Conclui-se que os tópicos analisados neste trabalho apresentam um panorama sobre a produção acadêmica em artigos sobre dupla carreira acadêmico-esportiva na América Latina, ao mesmo tempo em que destaca lacunas importantes a serem preenchidas por futuros estudos.
Very weak solution for the stationary exterior Stokes equations with non-standard boundary conditions in $L^p-$theory.
Authors: Dhifaoui Anis
Published: February 2022

In this work, we study the very weak solution for the stationary
exterior Stokes problem with Navier slip boundary condition. We try to
investigate some results of the existence and the uniqueness of
solutions related to this problem in an exterior domain in
$L^p-$theory where $1
Effects of drought on the physicochemical, nutrient and carbon metrics of flows in the Savannah River, Georgia, USA.
Authors: Wilbanks Kelsey A. , Sutter Lori A. , Batzer Darold P.
Published: February 2022

Hydrological drought has wide-ranging impacts on water quality, nutrient
and carbon metrics that are critical to investigate with the increased
drought frequency predicted with climate change. This study compared
physicochemical parameters (temperature, conductivity, pH and DO),
nutrients (TN, NO , NH , TP) and
carbon (TOC and DOC) between hydrological drought conditions
(2006–2009) and hydrological normal conditions (2016–2019) at five
sites along the lower Savannah River (Georgia, USA). We unexpectedly
found temperature (F =4.27, p=0.04) was
significantly lower during drought conditions. Levels of pH (F
=11.99, p<0.01) and DO (% saturation; F
=9.17, p=0.01; and mg L ; F
=4.04, p<0.01) were significantly higher
during drought. We found TN (F =5.23, p=0.02), TOC
(F =30.22, p<0.01) and DOC concentrations
(F =30.22, p<0.01) were significantly
lower during drought, but NO concentrations (F
=4.04, p=0.05) were significantly higher during
drought. Conductivity only varied at the lower river sites, being
significantly higher during drought at Sites 3 (F
=12.56, p<0.01), 4 (F
=12.96, p<0.01) and 5 (F
=17.60, p<0.01). These complex changes
could be attributed to volume reductions coupled with an increase in the
percentage of total flow originating from groundwater and limnetic
reservoir inputs, persistent point source pollution, reduced natural
catchment inputs and/or reduced floodplain interactions. The changes
that occurred during drought may be disruptive to aquatic life, not only
from reduced water quantity but also due to a scarcity of some
biologically essential materials and lower food resources, combined with
artificially high levels of some other potentially stressful materials.
Subacute Combined Degeneration (SACD), Is it a cause of diffusion restriction of the Spinal cord? A Case Report with literature review
Authors: Safan Abeer , Ahmed Mayada , AlSalahat Ali , ElSetouhy Ahmed , own Ahmed
Published: February 2022

Subacute combined degeneration (SACD) of the spinal cord is a common
neurological manifestation of vitamin B12 deficiency. We report a rare
finding of hyperintense T2 signal in the dorsal and lateral columns with
restricted diffusion in MR study of the thoracic spine in 47 years old
diagnosed with SACD.
Clinical Presentation and Outcomes of Hospitalized Children with COVID-19 in Mexico City
Authors: Diaz David , Urrutia Samuel , Gutierrez Gabriel , Cuevas Francisco
Published: February 2022

We describe the demographic, clinical, radiological and laboratory
findings relating them also to the severity and clinical outcome of 129
children (0-18 years) which were admitted to a tertiary care pediatric
hospital in Mexico City due to SARS- CoV-2 infection between April 1,
2020, to March 31, 2021. The infection was confirmed using RT-PCR. Fever
(82.2%), tachypnea (72.1%) and cough (71.3%) were the most commonly
reported signs at the moment of hospitalization. The most frequent
radiological pattern that stood out was the interstitial pattern
(66.7%). History of oncologic pathology (25.6%) was the most frequent
past medical history. ESR (erythrocyte sedimentation rate) was the only
laboratory value significantly associated with severity (p=0.015).
NSAIDs (93%), antibiotics (57.4%), and steroids (40.3%) were the most
common medication given. The average hospitalization stay was 14.2 days,
21.7% of the total patients required transfer to the intensive care
unit. At discharge, 20.2% required oxygen on an outpatient basis, and
unfortunately 7.0% of the patients who were admitted to the institute
for COVID-19 died. Our findings confirm that COVID‐19 in children has a
mild presentation except for patients with hematologic/oncologic
co-morbidities which had severe presentations.
Airway Multidrug-Resistant Organisms in a Population of Tracheostomy and Chronic Ventilator-Dependent Children at a Tertiary Care Pediatric Hospital
Authors: Havens Tara , Rosen David , Rivera-Spoljaric Katherine
Published: February 2022

Background Children with tracheostomies are at an increased risk of
bacterial respiratory tract infections. Infections caused by
multidrug-resistant organisms (MDROs) are more difficult to treat and
can result in severe complications. We investigated the risk factors and
sequelae of MDRO positivity in tracheostomy and chronic
ventilator-dependent children. Methods We performed a retrospective
chart review of 75 tracheostomy and chronic ventilator-dependent
children at St. Louis Children’s Hospital. Data on demographics,
respiratory cultures, hospitalizations, emergency department (ED)
visits, and antibiotic usage were collected. We determined the frequency
of MDRO positivity and compared the number of hospitalizations, number
of ED visits, and antibiotic usage in patients with and without
MDRO-positive cultures. Patient clinical variables were analyzed before
and after MDRO acquisition. Results We found 75.7% (56/74) of our
participants had an MDRO-positive culture, with methicillin-resistant
Staphylococcus aureus (MRSA, n=36, 64%) and Pseudomonas aeruginosa
(n=8, 14%) being the most commonly detected organisms. Patients with
MDRO-positive cultures had a greater number of annual non-pulmonary
admissions [OR=1.99, 95% CI (1.21-3.29), P= 0.008], inpatient
antibiotic courses [OR=1.27, 95% CI (1.07-1.50), P=0.006], total
antibiotic courses [OR=1.26, 95% CI (1.08-1.48), P= 0.004], and
chronic antibiotic use [OR=2.31, 95% CI (1.12-4.74), P=0.03]
compared to MDRO-negative participants. Patients that acquired MDROs
during the study period subsequently required increased outpatient
antibiotics [P= 0.006] but did not have increased pulmonary
admissions or ED visits. Conclusion Frequent antibiotic usage and
hospitalizations increase the risk of MDRO acquisition in children with
tracheostomies and ventilator-dependence. Further antibiotic stewardship
may help prevent resistant infections in technology-dependent children.
MEDICINAL FUNGI
Authors:   Dept. of Microbiology, College of Medicine, Al-Nahrain University, Baghdad, Iraq, Al-Attraqchi Azhar
Published: February 2022

Medicinal fungi are those fungi, which produce medically significant metabolites or can be induced to produce such metabolites using biotechnology. The range of medically active compounds that have been identified include antibiotics, anti-cancer drugs, cholesterol inhibitors, psychotropic drugs, immunosuppressants and even fungicides. Although initial discoveries centered on simple molds of the type that cause spoilage of food, later work identified useful compounds across a wide range of fungi. Keywords:Medicinal, fungi Citation:Al-Attraqchi AAF. Medicinal fungi. Iraqi JMS. 2019; 17(1): 1-3. doi: 10.22578/IJMS.17.1.1