bluuebunny/crossref_metadata_2025 huggingface dataset:
Overexpression of TRIM44 mediates the NF-kB pathway to promote OC progression and metastasis
Authors: Yu Yang , Li Shi ying , Xie Liang-Zhen , Guo Ying , Li Jia , Shen Ying , Fu Yang , Han Feng-Juan
Published: May 2022

Background: TRIM44 is highly expressed in both ovarian cancer tissues and cells, and is significantly associated with clinicopathological factors and poor prognosis. However, its effect on the malignant biological behavior of ovarian cancer cells and its potential mechanism of action have not been revealed. Therefore, we aimed to investigate the role and potential mechanism of TRIM44 on ovarian cancer.Methods: Using shRNA transfection to overexpress TRIM44, we investigated the effects of TRIM44 overexpression on the proliferation, migration, invasion and apoptosis of ovarian cancer cells and the growth ability of xenograft tumors through in vivo xenograft mouse models and in vitro experiments. In addition, to further elucidate its molecular mechanisms of action affecting ovarian cancer progression and metastasis.Results: TRIM44 overexpression significantly promoted the proliferation, migration, and invasion of SKOV3 cells and inhibited apoptosis in vitro while promoting tumor growth in vivo. Mechanistic studies have shown that TRIM44 overexpression contributes to ovarian cancer cells invasion, metastasis, and anti-apoptosis by upregulating the levels of inflammatory cytokines (TNF-α, IL-1β, IL-8) in the tumor microenvironment, stimulating the secretion of IKKβ factors, further promoting IKBα degradation and phosphorylation, initiating NF-kB p65 entry into the nucleus, and activating the NF-kB signaling pathway to upregulate or downregulate the expression of Metallo-matrix protease (MMP-9), and apoptotic genes (Bcl-2, Caspase-3).Conclusions: These data suggest that TRIM44 overexpression promotes ovarian cancer progression and metastasis by promoting NF-kB signaling pathway activation. These results provide evidence for TRIM44 as an oncogene in ovarian cancer and suggest that it may be a potential target for ovarian cancer therapy.
Simultaneous opening-wedge distal tubercle osteotomy and double-bundle anterior cruciate ligament reconstruction for anterior cruciate ligament-deficient knees with medial compartment osteoarthritis: technical tip
Authors: Kawai Ryosuke , Kawashima Itaru , Tsukahara Takashi , Kusaka Yoshiaki
Published: May 2022

The surgical outcomes of simultaneous anterior cruciate ligament reconstruction (ACLR) and high tibial osteotomy (HTO) are good in ACL-deficient knees with medial compartment osteoarthritis (OA). However, this procedure has issues to be solved, such as mild knee instability and progression of OA after surgery. Herein, we introduce our surgical procedure and technical tip of opening-wedge distal tubercle osteotomy (OWDTO) performed simultaneously with anatomical double-bundle ACLR (DBACLR). This procedure aims to achieve long-term knee stability by anatomically reconstructing the ACL using the double-bundle technique even though ACLR and OWDTO are both performed for ACL-deficient knees with medial compartment OA.
Integrated miRNA-mRNA analysis revealed distinct molecular signatures and regulatory networks in cancer stem-like cell models of hepatocellular carcinoma
Authors: Ayob Ain Zubaidah , Said Nur Akmarina Mohd , Ramasamy Thamil Selvee
Published: May 2022

Purpose: Tumour micro-niche and cancer therapeutics have been implicated in cancer stem cells (CSCs) enrichment, contributing to cancer heterogeneity, aggressiveness, and resistance, eventually leading to metastasis and tumour relapse. We aim to clarify how these cellular pressures differentially influence the enrichment of CSC-like cells and elucidate the molecular regulatory networks underlying distinct CSCs. Method: Three HepG2-derived CSC-like models were established to recapitulate CSC induction from different pressures including i) tumoursphere (3D-HepG2), ii) TGF-β1-induced epithelial-mesenchymal transition (EMT; TβT-HepG2) and iii) cisplatin-resistant (CisR-HepG2) models. These models were then subjected to an integrated miRNA and mRNA profiling and molecular regulatory network analysis. Results: All models exhibited enrichment of aldehyde dehydrogenase positive cells with differential upregulations of CD133 and distinct EpCAM species upregulated between different models. These models shared common propensity for increased stemness, quiescence, invasion, migration, and chemoresistance, while proliferation and EMT features were differential. Profiling analysis revealed the differentially expressed miRNA and mRNA of the 3D-HepG2 clustered closely to the parental, whereas distinct profiles were displayed by the TβT-HepG2 and CisR-HepG2. Seven miRNAs (miR-19b-3p miR-23a-3p, miR-29a-3p, miR-92a-3p, 125a-5p, miR-181a-5p, miR-483-3p) and 24 mRNAs - among which include CCNB1, PI3KR5, MAP2K6, MAPK10 and MAPK11, were identified as key drivers underlying the molecular regulatory networks of these CSC-like models. Notably, the integrated analysis revealed the FoxO/PI3K-Akt/MAPK signalling and regulation G2/M transition and mitotic spindle checkpoints of cell cycle were identified as common network through the regulation of the key drivers.Conclusion: Altogether, the molecular regulatory networks from the three CSC-like models provide insights into the mechanisms regulating cancer plasticity and heterogeneity that may potentially be harnessed for the development of improved therapeutic approaches in targeting CSC for cancer treatment.
Vision-related Quality of Life After Cataract Surgery in West Africa
Authors: Signes-Soler Isabel , Javaloy Jaime , Montés-Micó Robert , Muñoz Gonzalo , Llamusí Raúl Montalbán , Baeza Ana Maria Hernandez , Albarrán-Diego César
Published: May 2022

AIMSTo study the vision related quality of life (VRQoL) before and after a mass cataract surgery campaign in a low-income country and to describe the impact of cataract surgery on quality of life (QOL). METHODSAll the patients who had cataract surgery in Bobo-Dioulasso (Burkina Faso) during a campaign for the prevention blindness were examined. VRQoL was assessed using a modified version of the WHO/PBD VF20. The questionnaire was carried out before and three months after the surgery. A QOL related to vision index (QOL-RVI) was calculated from the scores obtained.RESULTSA total of 305 patients (56.1% male) underwent cataract extraction. Mean age was 61.97 ± 14.39 years. The majority of eyes (88.70%) had preoperatively poor visual acuity (CDVA<20/200). Three months after surgeries, good visual outcomes (VA ≥20/60) were achieved in 38.35% of eyes without correction and 68.7% with correction. At this time, QOL-RVI had improved postoperatively in 90.2% of patients, had not changed in 3.1% and was worse in 6.7%. Significant differences were detected (Wilcoxon test p <0.05) for all items tested before and after surgeries. Correlations for the patients after operations showed that there was a significant relation between a global estimated QOL-RVI and the UCVA previous to the surgery (ρ -0.196 p=0.014), regarding the same index and the BCVA after the procedures (ρ -0.35 p=0.00018). CONCLUSIONSCataract surgery increases the quality of life of patients living in low-income countries such as Burkina Faso and the improvement correlates with the recovery of the visual acuity.
TLR2 genetic diversity associated with the risk of Schizophrenia development in a Tunisian population
Authors: Ayari fayza , Chaaben Arij Ben , Abbaza Hajer , Mihoub Ons , Ouni Nesrine , Mankai Amani , Boukouaci Wahid , kharat Maher , Leboyer Marion , Tamouza Ryad
Published: May 2022

Objectives: Schizophrenia (SZ) is a multifactorial disorder involving complex interactions between genetic and environmental factors, where immune dysfunction plays a key etiopathogenic role. In order to explore the control of innate immune responses in SZ, we aimed to investigate the potential association of nine TLR2/TLR4 polymorphisms (TLR2: rs4696480T>A, rs3804099T>C, rs3804100T>C; TLR4: rs1927914G>A, rs10759932T>C, rs4986790A>G, rs4986791T>C, rs11536889G>C and rs11536891T>C) with susceptibility to SZ in a Tunisian population. Methods: TLR2-4 genotyping was done using a TaqMan 5’-nuclease assay for 150 SZ patients and 201 healthy controls (HC) with no history of psychiatric illness.Results: We found that only the TLR2 rs4696480T>A polymorphism was significantly associated with SZ. Indeed, the AA genotype was significantly associated with an increased risk of SZ (46% versus 31%, p= 4.7*10-3, OR =1.87 and 95% CI [1.18-2.97]). The frequency of the TA genotype was significantly more prevalent in HC than in SZ patients (27% versus 43%, p=2.1*10-3) and may be associated with protection against SZ (OR = 0.49 and 95% CI [0.30- 0.80]). The ACT haplotype of the TLR2 gene was identified as a risk haplotype for SZ. Moreover, we found a significant association between AA genotype and domestic violence (AA versus TT+AT; 71% versus 49%; p= 0.036, OR = 3.24, 95% CI = 1.20–10.80). Concerning the other polymorphisms no significant association was found.Conclusion: The results indicate that TLR2 genetic diversity may play a role in genetic vulnerability to SZ.
Insect-killing parasites infection of South American tomato pinworm, Tuta absoluta (Meyrick), on F 1 hybrid tomato crop
Authors: Kasi Indra Kumar , Singh Mohinder , lamichhane Pratikshya , Malik Abaker M. , Rostami Elahe , Waiba Kanchhi Maya
Published: May 2022

Background
A survey was conducted to determine the diversity and frequency of endemic entomopathogenic nematodes (EPNs) in fruit orchards soils in Rajgadh Himachal Pradesh, India. The main aim of the survey was to obtain nematodes as biological control agents against tomato leafminer Tuta absoluta, an invasive pest of the tomato crop in India.
Results
From a total of 42 samples, 7 samples tested positive for the presence of EPN. EPNs & test insect sequencing and characterization of the internal transcribed spacer (ITS) 18S & 12S region were used to identify all nematode isolates and test insect species levels. Steinernema feltiae (isolate- HR1) and Heterorhabditis bacteriophora (isolate- HR2) species dose (10, 20, 40, 80, 160 IJs/cm2) are used in the laboratory bioassay. The third instar (percentage) ranges from 24.15 to 90.00 percent. HR1 and HR2 isolates demonstrated significant larvicidal activity with LD50, LD75, and LD90 of all instars and pupa showing high mortality from 31.53 to 90.00 percent a and 72-hours exposure duration. The strain slows larval development in 48 to 72 hours of the exposure period, with LD50 values ranging from 05.42 to 19.29, LD75 values ranging from 20.29 to 83.12, and LD90 values ranging from 26.03 to 78.89. Greenhouse test same isolates are foliar sprayed three times at a 14-day interval, with total findings revealing a 7.36 count range before spraying. The total treatment outcomes range from 1.64 to 1.74 for isolate HR2, and 1.88 and 2.03 for HR1. 4.15 percent was recorded in the control plot.
Conclusions
Invasive species pose a significant threat, as evidenced by this research. Traditional EPNs (S. feltiae HR1, H. bacteriophora HR2) have been used as an active biocontrol agent in laboratory and greenhouse settings and the pathogen that infects T. absoluta.
Self-mixing in microtubule-kinesin active fluid from nonuniform to uniform distributions of activities
Authors: Bate Teagan , Varney Megan , Taylor Ezra , Dickie Joshua , Chueh Chih-Che , Norton Michael , Wu Kun-Ta
Published: May 2022

Active fluids have potential applications in micromixing, but little is known about the mixing kinematics of systems with spatiotemporally varying activities. Ultraviolet light–activated caged ATP and fluorescent dyes were used to activate controlled regions of microtubule-kinesin active fluid, creating a binary active-inactive fluid where the progression of mixing was observed. At low flow-speed levels, mixing was governed by active fluid-induced diffusion-like processes at the active-inactive interface, but at higher flow-speed levels, mixing was governed by active fluid-induced superdiffusion-like processes. Samples activated in a checkerboard pattern reached homogeneity faster than those that were activated only on one side. A model of active nematohydrodynamics coupled to ATP transport was used to describe the coupled mixing process. The results show that the mixing of active fluid systems with initially nonuniform activities is governed by the complex active transport of ATP at the interface between active and inactive regions.
Attributes that influence human decision-making in complex health services: A scoping review
Authors: Doreswamy Nandini , Horstmanshof Louise
Published: May 2022

Humans currently dominate decision-making in both clinical health services and complex health services such as health policy and health regulation. This scoping review identifies and maps attributes that influence human decision-making in complex health services. A systematic search identified 140 potential articles. Inclusion and exclusion criteria were developed. Based on these criteria, four articles were deemed relevant. Four additional articles were added through citation tracking. The results of this review highlight key themes that underline the complex and nuanced nature of human decision-making. The results suggest that rationality may be entrenched, and may influence the lexicon of our thinking about decision-making. The results also highlight the counter narrative of decision-making that is underpinned by the uniquely human attribute of intuition. The review, itself, takes a rational approach, and the methods used were suited to this.
Diurnal variation in methane emission from a paddy due to temperature-sensitive ebullition
Authors: Kajiura Masako , Tokida Takeshi
Published: May 2022

The diurnal variation in methane (CH4) emission observed in rice paddies has been linked to changes in air and soil temperatures. The temperature dependence is not simple, however, and the mechanisms underlying it in relation to the diurnal variation are still poorly understood. Here, we investigated the diurnal variation of CH4 flux and its relationship with air temperature in a Japanese paddy by dividing the total flux into two major pathways, plant-mediated and bubbling emission. The diurnal variation of total flux was not clear at the panicle formation and booting stages, when plant-mediated emission was dominant. At the heading stage, ebullition made a substantial contribution to the total emission (43–70%), and CH4 emission via both pathways varied diurnally; however, the diurnal range was much greater for bubbling emission (ratio of max. to min. = 3.5) than for plant-mediated emission (ratio of max. to min. = 1.4). Bubbling emission at the heading stage increased with increasing temperature in the morning, but it started to decrease drastically when the temperature reached a plateau, forming a hysteresis in the flux versus temperature relationship. These results indicate that abiotic processes, such as a change in the solubility of gases and the temperature dependence of the gas-phase volume (Charles’s law), may play a central role in shaping the diurnal pattern of the CH4 ebullition. Our findings also provide some insights into the appropriate timing of CH4 flux measurements in the field, especially where ebullition occurs actively and measurement frequency is limited.
Health workers’ perspectives on vacuum extraction in Mulago Hospital, Uganda
Authors: Capelle Manuela , Nolens Barbara , Lule John , Byamugisha Josaphat , Roosmalen Jos , Akker Thomas
Published: May 2022

Background
To explore perceptions of health workers of Mulago Hospital, Uganda, regarding the use of vacuum extraction.
Methods
A cross-sectional survey among midwives, residents and consultant obstetricians was performed. It was composed of questions pertaining to vacuum extraction, addressing reasons for low use, recommendations to increase use, preferred mode of birth in case of prolonged second stage for oneself or one’s relative, views about who is suited to perform the procedure and contraindications.
Results
Eighty-three of 134 (61.9%) participants returned the survey. The most frequent reasons for low use of vacuum extraction were lack of training (60/83, 72.3%) and equipment (59/83, 71.1%). Skills training and improved supply of equipment were recommended. Most participants (57/83, 68.8%) chose vacuum extraction over caesarean section as hypothetical mode of birth for themselves or a relative in case of prolonged second stage of labour. Opinions about contraindications varied. There was a tendency to cite contraindications not identified as such in international guidelines (big baby, caput succedaneum, moulding). Midwives, residents, interns and consultant obstetricians with appropriate training were generally all considered suited to perform vacuum extraction.
Conclusions
Health workers generally conveyed a positive attitude towards vacuum extraction, despite some perceived barriers, often unsupported by evidence. Organisation of skills training, supply of equipment and focus on knowledge of indications are essential to increase its use.
The relationship between nutrition and cancer in elderly hospitalized patients: a retrospective chart analysis
Authors: Yang Lina , Wu Lan
Published: May 2022

Background: The purpose of the present study was to retrospectively analyze the relationship between nutrition and cancer in elderly hospitalized patients. Methods: A total of 339 elderly patients were divided into cancer and non-cancer groups. Information regarding nutritional blood parameters (NBP), including TP, ALB, PA, TLC, and Hb; nutritional risk screening (NRS), including ADL, MNA-SF, WST; and polypharmacy was collected and analyzed.Results: Among the 339 patients, 94 (27.7%) were women, 81 (23.9%) were cancer patients, and 258 (76.1%) were non-cancer patients. Overall, 25.3% of patients were malnourished. Patients in the cancer group were younger, with higher rates of inflammation, lower rates of polypharmacy and swallow dysfunction, increased ADL, and decreased MNA-SF score. The BMI, TP, PA, Hb, and TLC were notably decreased in cancer patients. The MNA-SF score had a positive correlation with BMI, TP, ALB, PA, Hb, TLC, and ADL, but a negative correlation with CRP, WST score, polypharmacy, and age. Conclusion: There was a close relationship between nutritional status and cancer in elderly patients. Geriatric patients with cancer were more prone to a poor nutritional status. Nutritional screening, assessment, and intervention should be increased to improve the prognosis in cancer patients.
Hidden conformal symmetries from Killing towers with an application to large-D/CFT
Authors: Keeler Cynthia , Martin Victoria , Priya Alankrita
Published: May 2022

We generalize the notion of hidden conformal symmetry in Kerr/CFT to Kerr-(A)dS black holes in arbitrary dimensions.
We build the SL(2, R) generators directly from the Killing tower, whose Killing tensors and Killing vectors enforce the separability of the equations of motion.
Our construction amounts to an explicit relationship between hidden conformal symmetries and Killing tensors: we use the Killing tower to build a novel tensor equation connecting the SL(2,R) Casimir with the radial Klein-Gordon operator. For asymptotically flat black holes in four and five dimensions we recover previously known results that were obtained using the ``near-region'' limit and the monodromy method.
We then perform a monodromy evaluation of the Klein-Gordon scalar wave equation for all Kerr-(A)dS black holes, finding explicit forms for the zero mode symmetry generators.
We also extend this analysis to the large-dimensional Schwarzschild black hole as a step towards buliding a Large-D/CFT correspondence.
Modern markers of inflammatory process in surgical practice
Authors: Morozov A. M. , Sergeev A. N. , Zhukov S. V. , Novikova N. S. , Belyak M. A.
Published: May 2022

Introduction. Currently, one of the important problems in surgery is the search for new markers of the inflammatory process to determine the prognosis of the disease, substantiate the need for surgical intervention and to assess the effectiveness of treatment.

Aim. To evaluate the possibilities and prospects of using modern markers of the inflammatory process in the practice of a surgeon.

Materials and methods. In the course of the present investigation we analyzed relevant sources of domestic and foreign literature on the topic of application and possibilities of use of modern inflammatory process markers in various fields of medicine. Information was collected from databases of ScienceDirect, Cyberleninka.ru, and PubMed.

Results. Acute phase proteins, as markers of inflammation, are valuable tools in the diagnosis, treatment and prognosis of inflammatory diseases, as they are sensitive to systemic inflammation. Important criteria for the use of biomarkers of inflammation are: a low number of false positive results and the possibility of using the marker not only as an indicator of the disease, but also to determine the severity of the patient’s condition. In order to assess the presence of inflammation in clinical conditions, laboratories evaluate the concentrations of various acute phase proteins in plasma. Currently, the most relevant markers of inflammatory processes are: C-reactive protein; haptoglobin; presepsin is also an early indicator of inflammation; fibrinogen; serum amyloid A; a complement system containing key markers of inflammation. Determining them in the surgeon’s practice will allow you to predict the outcome of the disease and evaluate the results of treatment.

Conclusion. At the moment, the determination of inflammatory markers helps in predicting the disease, planning treatment tactics, evaluating the effectiveness of therapy after surgery and in earlier diagnosis of severe conditions.
Osteoarthritis: modern possibilities of therapy
Authors: Filatova Yu. S. , Ilyin M. V. , Soloviev I. N.
Published: May 2022

The article discusses the treatment of osteoarthritis (OA). In recent decades, ideas about the pathogenesis of OA have undergone significant changes. If at the dawn of the study OA was presented as a degenerative process associated with age, now that some immunological and genetic aspects of the disease have become known, the idea of the pathogenesis of OA has changed. Currently, there are clinical guidelines developed by professional communities that define approaches to the diagnosis and treatment of patients with OA. In Russia, the Association of Rheumatologists and Orthopedic Traumatologists in 2021 developed clinical guidelines for the management of patients with gonarthrosis and coxarthrosis, but currently no clear consensus has been developed in any of the treatment recommendations regarding the use of nutraceuticals and dietary supplements. While according to published studies of plant and botanical nutraceuticals developed from natural products, promising data on efficacy compared to placebo drugs and their potential for the treatment of patients with OA have been demonstrated. According to a study conducted by N.E. Lane et al., patients with OA regularly use supplements, as well as over-the-counter products in combination with prescription drugs, and the likelihood of using prescription products increases with increasing duration and severity of OA. And currently there is not enough knowledge and information about the possibilities of additional use of nutraceuticals in the treatment of patients. The article discusses the composition of the biologically active additive, which has anti-inflammatory, anti-catabolic and antiproliferative effects and can be considered as an addition to NSAIDs, chondroitin sulfate, glycosamine (sulfate or hydrochloride) and their combinations in OA. Type II collagen peptide, curcumin (curcuminoids 95%), black pepper extract (piperine) and Boswellia pilchata extract in clinical studies have demonstrated efficacy and safety in the treatment of patients with OA. A number of studies have also found a number of pleootropic effects. Effects such as anti-inflammatory, neuroprotective, immunomodulatory, cardioprotective and antitumor effects will be important in patients with comorbidity.
Rol mediador del conflicto trabajo-familia en la relación entre justicia organizacional y estrés laboral
Authors: Rodríguez Díaz Viviana , Barroilhet Yasmín , Carrasco Rocío , Guzmán Andrea , Carvajal Karla , Galaz Daniela
Published: May 2022

Si bien los efectos de las percepciones de justicia organizacional global sobre las percepciones de estrés laboral han sido demostrados en estudios previos, los mecanismos que subyacen a esta relación no resultan explícitos. La investigación actual plantea que las jefaturas percibidas como más justas potencian la capacidad del trabajador para conciliar sus roles laborales y familiares, impactando positivamente sus niveles de estrés. El objetivo de este estudio es analizar, en un contexto laboral latinoamericano, el rol mediador del conflicto trabajo-familia en la relación entre las percepciones de justicia organizacional global y estrés laboral; y analizar diferencias entre hombres y mujeres respecto al conflicto trabajo-familia. Participaron 129 trabajadores pertenecientes a una institución pública chilena, quienes contestaron un cuestionario de autoreporte. Se efectuaron correlaciones bivariadas de Pearson, Tau-b de Kendall, prueba t de Student y modelamiento de ecuaciones estructurales. Los resultados mostraron la existencia de una correlación negativa y significativa entre las percepciones de justicia organizacional global y el estrés laboral. Además, esta relación estuvo mediada parcialmente por el conflicto trabajo-familia, es decir, las percepciones de justicia organizacional se asociaron de manera directa e indirecta al estrés laboral, a través del conflicto trabajo-familia. Respecto de la variable género y el conflicto trabajo-familia, no se encontraron diferencias significativas. Este estudio aporta evidencia empírica sobre la importancia de las percepciones de justicia organizacional global, y sus resultados orientan el diagnóstico y la elaboración de modelos de prevención e intervención más específicos desde el campo de la psicología de la salud ocupacional.
A tomportáji combcsont-törések kezelésének eredményei osztályunkon
Authors: Lenkei Balázs , Szikszay Levente , Aszalós Gergely , Kazacsay Ferenc
Published: May 2022

A Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház Traumatológia Osztályán 2011-ben 385 esetben került sor műtétre tomportáji femurtörés miatt. A nagy esetszámot kihasználva készítettük el összehasonlító vizsgálatunkat, amelyben két különböző implantátummal kezelt betegeink eseteit hasonlítottuk össze. Értékeltük az elért repozíciós helyzetet, az implantátum elhelyezkedését a posztoperatív röntgenfelvételeken, követtük az átépülés folyamatát a kontroll röntgenképeken, és figyeltük az esetleges szövődmények gyakoriságát. A 385 műtét kapcsán mindössze 27 esetben (7%) került sor reoperációra szeptikus szövődmény vagy csavarlazulás miatt; ez az arány a nemzetközi átlag alatt van. A két eljárással elérhető átépülési arányban szignifikáns különbséget nem találtunk.
Fáradásos törések gyermekkorban
Authors: Farkas Tamás , Fodor Krisztina
Published: May 2022

Napjainkban fokozódik az érdeklődés a mindennapi fizikai aktivitás, a tömegsport iránt. A sporttal együtt jár a teljesítmény hajszolása, ezért egyre gyakrabban és egyre fiatalabb korban találkozunk a túlterhelésből származó különböző sérülésekkel. Ezek a problémák az élsportolóknál mindennaposak, de a jobb általános kondíció érdekében növekvő edzésmunkát végző amatőr és szabadidő sportolók között is nő a sportsérülések, ezen belül a fáradásos törések előfordulása. A diagnózis kulcsa az, hogy gondoljunk a fáradásos törésre, ha elhúzódó panaszok mellett a hagyományos vizsgálatok nem mutatják ki annak okát.
Váparekonstrukciós lehetőség kiterjedt os ilii defektus esetén revíziós műtétekben
Authors: Bejek Zoltán , Lakatos József , Skaliczki Gábor , Szendrői Miklós
Published: May 2022

Csípőprotézis vápakomponensének cseréje nagy iliacalis csontdefektus esetén nehézségeket okozhat a műtét során. Ilyen esetben felmerül esetleges Girdlestone helyzet visszahagyása, amely a beteg életminőségének romlásához vezethet. Amennyiben a csontdefektus masszív csont grafttal pótolható, úgy jó támasztékot nyerhetünk vápakosár segítségével a jó fedettség elérésére és új vápa beültetése számára. A Semmelweis Egyetem Ortopédiai Klinikáján 20 esetben végeztünk a Paprosky III.a. acetabulum defektus esetén váparevíziót szolid csontgraft és vápakosár alkalmazása mellett, amely után az átlagos utánkövetési idő 49 (5–108) hónap volt. A betegek utánvizsgálata során Harris Hip Score-t töltöttünk ki, vizuális analóg skála (VAS) segítségével megítéltük a fájdalmuk mértékét. Kétirányú csípőröntgen alapján megvizsgáltuk a beültetett csont és vápakosár stabilitását. Ennek során a Harris Hip Score-t átlagosan 74 (94–48.5) pontnak adódott, a vizuális analóg skála (VAS) a műtét előtti átlagos 8.4 (4–10) pontról 1.7 (0–10) pontra csökkent. Radiológiai elemzés során négy betegnél észleltünk a Gruen hármas zónában 2 mm-nél szélesebb lyticus sávot, három esetben észleltünk 1–1 csavar törését. Tapasztalataink alapján, nagyobb iliacalis csonthiány esetén szolid homológ cortico-spongiosus blokk stabilitása és teherbírása megbízható egy vápakosaras revízió számára, így súlyos vápadestrukció esetén is alkalmasnak találjuk a homológ csontgraft vápakosárral történő kombinációját a rekonstrukcióra. Ezáltal sok esetben elkerülhető a beteg számára megterhelő Girdlestone helyzet annak az életminőséget rontó minden hatásával.
Spasticus felső végtag sebészi rehabilitációja agykárosodott betegeknél Cerebralis paresis – traumás agysérülés – stroke
Authors: Turcsányi István , Vekerdy-Nagy Zsuzsanna , Dénes Zoltán , Mészáros Edit , Hőgye Zsófia , Noviczki Miklós , Farkas Csaba
Published: May 2022

Ebben a tanulmányban a szerzők áttekintik a Nyíregyháza Jósa András Megyei Kórház Ortopédiai Osztályán operált cerebral paresises, traumás agysérült és stroke-betegek felső végtagi rekonstrukciós műtétjeit az elmúlt tíz év anyagából, ismertetik a műtétek típusait és eredményeit. A 44 betegen (cerebral paresis n=26, traumás agysérült n=9, stroke n=9) elvégzett ötvennyolc műtét 304 beavatkozást jelent, amelyek elemzése retrospektív úton történt. A sebészeti beavatkozás során 198 lágyrész-felszabadítást, 89 ínáthelyezést és 17 ízületstabilizáló műtétet végeztek. A betegek átlagéletkora 32 év (7–66 év), közülük 27 férfi és 17 nő. A felső végtag műtét előtti és műtét utáni funkcióját a 9 szintű House-féle funkcionális score-ral vizsgálták, amely során valamennyi betegnél átlagosan 2 szint (1–4 szint) javulást észleltek.
A dysplasiás femur protetizálásának eltérő megoldási lehetőségei csípő TEP beültetésekor
Authors: Szuper Kinga , Kuzsner József , Vermes Csaba , Than Péter
Published: May 2022

A veleszületett csípőízületi dysplasiánál az acetabulum és a femur normálistól eltérő anatómiai megjelenése a primer csípőprotézis beültetést megnehezíti. Míg a vápánál az acetabulum hypoplasiája jelenti a fő problémát, addig a femurnál számítanunk kell a fokozott antetorzióra, a szűk velőűrre, a nyak fokozott valgus állására. Az anatómiai szituációt tovább bonyolítják a korábban elvégzett műtétek. A problémák megoldására két lehetőség közül választhatunk, használhatunk kisméretű hagyományos protézisszárat, vagy annak dysplasiás változatát. A szerzők közleményükben esetismertetések formájában mutatják be az általuk leggyakrabban használt dysplasiás szártípusokat, valamint áttekintik a témában megjelent nemzetközi irodalmi ajánlásokat. Hangsúlyozzák, hogy valamennyi esetben a különböző szártípusok ellenére is jó funkcionális és radiológiai eredményt értek el.
A csípőízület 3D modellezése gyermekkorban
Authors: Schlégl Ádám Tibor , Szuper Kinga , Somoskeöy Szabolcs , Than Péter
Published: May 2022

A csípőízület anatómiai és biomechanikai paramétereinek gyermekkori változása jól ismert. A normális tartományok rassz, kor és nem specifikus meghatározása nélkülözhetetlen a megfelelő diagnosztikai protokollok és kezelési indikációk felállításához. Kutatásunk céljául tűztük ki, hogy a rendelkezésünkre álló pontos és torzításmentes mérést lehetővé tévő eszköz (EOS 2D/3D) segítségével nemek szerinti bontásban meghatározzuk a gyermekkori csípőízület anatómiai paramétereinek normál tartományát a magyar populációban. A rutin diagnosztika során, ortopédiai indikációval készült EOS 2D felvételek közül kiválasztottuk azt az 523 felvételt, ami a 2–16 éves korosztályt ábrázolta és az alsó végtagok biomechanikáját befolyásoló eltérés nem igazolódott. A 4–16 éves korcsoportban elvégeztük az alsó végtag 3D modellezését, 2–3 éveseknél csak a femur fej átmérőjét mértük, majd a rekonstrukciós szoftver által kiszámított anatómiai paraméterek értékeit Kolmogorov–Szmirnov teszt, páros t–próba, Spearman korreláció és Welch–teszt segítségével vizsgáltuk. Minden mért paraméter összefüggést mutatott nemmel és korral. A paraméterek alábbi értékeket mutatták: femur fej átmérő fiúknál 23,8–45,7 mm, lányoknál 23,0–41,5 mm; femoralis eltoltság fiúknál 24,8–41,9 mm, lányoknál 23,7–37,6 mm; femurnyak hossza fiúknál 33,0–52,3 mm, lányoknál 31,4–48,0 mm; collodiaphysealis szög fiúknál 132,2°–127,3°, lányoknál 131,2°–129,3°; femur antetorziója fiúknál 22,4°–19,3°, lányoknál 21,6°–23,63°. Az EOS 2D/3D technológia alkalmas eszköznek bizonyult az alsó végtag anatómiai paramétereinek mérése gyermekkorban is. Sikerült a proximalis femurvég anatómiai paramétereinek normális tartományát meghatározni kor és nem specifikus csoportokban. Az általunk mért értékek változási tendenciája megfelel az irodalomban megtalálhatóknak, azonban az abszolút értékek változása sokkal kisebb, amit a módszer pontossága magyarázhat.
Csonkolt ujjak az őskőkorban
Authors: Józsa László
Published: May 2022

Az őskőkorban a francia és spanyol barlangokban a művészi alkotásokat készítő ősember kezét is megörökítette. A franciaországi Gargas és Tibiran barlangban rendszertelen ujjcsonkolódások látszanak, ezzel szemben a Maltravieso barlang kézlenyomatain egyöntetűen a kisujj utolsó két percét amputálták.
Legg–Calvè–Perthes kór középkori leleten
Authors: Józsa László , Papp Ildikó
Published: May 2022

Középkori temetőben fellelt 21–40 éves kora között elhunyt férfi vázmaradványain Legg–Calvè–Perthes kór gyógyulása utáni combfej, combnyak és acetabulum elváltozást állapítottak meg. Részletesen elemzik a morfológiai és radiológiai tüneteket, és táblázatban foglalják össze az ásatag anyagon elvégezhető elkülönítő kórisme adatait.
Gyakori diagnosztikus hibák és szövődmények a kézsebészetben : II. Szövődmények a kézsérülések ellátásában: Késői, különleges, komplex és súlyos sérülések (Irodalmi áttekintés)
Authors: Bíró Vilmos
Published: May 2022

A szerző a kézsérülések szövődményeivel foglalkozó, irodalmi összefoglaló dolgozatának második részében a késői, a különleges, a komplex és a súlyos sérülések ellátása során kialakult szövődmények felismerését és kezelési lehetőségeit tekinti át. A késői szövődmények közül tárgyalja a kozmetikai deformitások és a komplex regionális fájdalom tünetcsoport mellett a compartment szindróma kezelését. A különleges sérülések fejezetben a harapásos, a kémiai égési és az injekció okozta sérülések szövődményeinek leírását és terápiáját adja meg. A komplex sérüléseknél pedig a traumás csonkolások, az idegen testek, az égési és fagyási sérülések utáni komplikációkat veszi sorra. Végül a súlyos kézsérülések tárgyalása során foglalkozik a replantációs műtétek, illetve az érsérülések műtéteit követő szövődményekkel. Dolgozatának végéhez az érdeklődő szakemberek számára bőséges publikációs listát mellékelt.
Cyber resilience revisited: Law and international relations
Authors: Putranti Ika Riswanti , Hanura Marten , Ananda Safrida Alivia Sri , Nabila Gawinda Nura
Published: May 2022

Cyber space is increasingly playing an important role in the global world, affecting the pattern of relations between countries. The issue of non-traditional security threats is shifting towards the threat typology associated with cyber space. The concept of national security began to be complemented by a national cyber security strategy to support the security of its national interests. Where the country needs to ensure the security of cyber ecosystems to maintain national economic stability. The large flow data and information increasingly large and complex, and brings hidden costs in the form of cyber security threats. Cyber security concepts that are considered not responsive and resilient in dealing with and overcoming cyber attacks can occur at any time with patterns and types that continue to evolve. The concept of cyber security should begin to be developed into cyber security that has patterns of recovery, adaptation, and evolution so as to be able to answer the dynamics of challenges in international trade. Interrupted cyber systems in international sphere will potentially cause disruption of international relations because the threat of losses caused not only affects one country. The increasingly complex international law context and involving big data should be one of the top priorities for cyber resilience strategies. This paper starts by explaining the state of play of cyber resilience in international relations and law. Next, analysis why the concept of cyber resilience in the perspective of international relations and international law needs to be re-visited to face challenges in the digital economy.
Developing writing skills among students with learning disabilities in English language
Authors: Khasawneh Mohamad Ahmad Saleem , Alatoom Eman Khaled Tawafiq
Published: May 2022

This study explored the effect of active learning on developing writing skills among students with learning disabilities in English language in Irbid, Jordan. The sample of the study included (40) male and female students, who were selected purposefully, and distributed randomly into two groups. The first was one the experimental group that was taught using the active learning method, and the other was the control group that was taught according to the traditional method. The study used the writing test after checking its validity by presenting it to a group of arbitrators, and its reliability by the method of testing and re-testing using the Pearson coefficient, which was (0.90). The results of the study showed that there were clear differences between the scores of the two study groups on the post-writing test. In light of the findings of the study, the researcher recommended training educational supervisors and teachers on practical applications of using the active learning method and evaluating it in the classroom through seminars and workshops in this field.
Religiosity and happiness inter generation of labor in Indonesia
Authors: Mustofa Mustofa
Published: May 2022

If people are religious, are they happier? This study tries to answer the preceding question and to determine the factors affecting happiness among Indonesian labor. The dummy generation variable was used to know whether Gen X, Gen Y, and baby boomers can affect happiness. Several variables were also examined related to happiness. This study can be categorized as empirical research using ordinary least squares. The data were sourced from the Indonesian Family Life Survey 2014 (IFLS5). The number of samples selected was 21,919 individuals with the criteria of individuals aged 15 years and over who worked and earned income. The data analysis technique used OLS regression to prove the factors that influence happiness. The results of the research showed that religiosity, education, ownership of assets, social, job satisfaction, and the dummy generation have a positive and significant effect on people’s happiness. This study has confirmed that religiosity is a factor that can affect people’s happiness. Another factor, the generation the person belongs to, also affects happiness.
Kierunki rozwoju energetyki w województwie mazowieckim w kontekście polityki klimatyczno-energetycznej Unii Europejskiej
Authors: Wereda Beata , Polak Elżbieta
Published: May 2022

W artykule omówiono problematykę zaopatrzenia województwa mazowieckiego w energię i paliwa, w tym systemy energetyczne funkcjonujące w regionie, a także przeanalizowano zmiany, które zaszły w przedmiotowym sektorze w latach 2010–2020 (w przypadku braku danych przyjęto krótsze okresy) oraz zamierzenia rozwojowe, określone w planach przedsiębiorstw energetycznych i tzw. specustawach energetycznych: ustawie z dnia 24 kwietnia 2009 r. o inwestycjach w zakresie terminalu regazyfikacyjnego skroplonego gazu ziemnego w Świnoujściu (specustawie gazowej), ustawie z dnia 24 lipca 2015 r. o przygotowaniu i realizacji strategicznych inwestycji w zakresie sieci przesyłowych (specustawie przesyłowej) oraz ustawie z dnia 22 lutego 2019 r. o przygotowaniu i realizacji strategicznych inwestycji w sektorze naftowym (specustawie naftowej). Przedstawiono również potencjał i wykorzystanie odnawialnych źródeł energii (OZE). Wykonane analizy pozwoliły na identyfikację przewidywanych głównych kierunków rozwoju sektora energetycznego na Mazowszu, spójnych z polityką klimatyczno-energetyczną UE i Polski. W artykule wykorzystano dane pozyskane na potrzeby aktualizacji strategii rozwoju województwa mazowieckiego, opracowanej przez Mazowieckie Biuro Planowania Regionalnego w Warszawie (MBPR). Słowa kluczowe: ciepło, energia elektryczna, gaz ziemny, odnawialne źródła energii, paliwa ciekłe, produkty naftowe, ropa naftowa, sieci dystrybucyjne, sieci przesyłowe, systemy energetyczne
Aktywność społeczna w kształtowaniu budżetu obywatelskiego
Authors: Dąbrowska Małgorzata
Published: May 2022

W społeczeństwie obywatelskim, samorządność jako forma organizacji społecznej zajmuje jedną z centralnych pozycji. Warunkiem realizacji misji rozwojowej samorządu jest uczestnictwo obywateli i ich współodpowiedzialność za kształt lokalnego życia społecznego. Ostatnio coraz popularniejszą formą partycypacji staje się budżet obywatelski, powodujący bezpośrednie zaangażowanie mieszkańców w proces podejmowania decyzji dotyczących wyboru zakresu zadań publicznych w ramach wyznaczonej puli środków i przejęcia części odpowiedzialności. Celem prezentowanej analizy jest ukazanie dynamiki zaangażowania obywateli w konsultacje, w sprawie kształtowania tej części budżetu miasta na zadania lokalne mieszczące się w kompetencjach samorządu lokalnego, jaką jest budżet obywatelski. Przyjęta hipoteza badawcza zakłada, że budżet obywatelski jest coraz bardziej popularną formą konsultacji, bowiem w swej formule daje mieszkańcom poczucie sprawstwa i podmiotowości w wyrażaniu swoich opinii i preferencji. Empiryczną podstawą analizy są sprawozdania z realizacji budżetu obywatelskiego miasta Radomia od początku jego powstania oraz literatura przedmiotu. Budżet obywatelski jest znakomitym narzędziem edukacji o samorządności, jest elementem konkretnej filozofii funkcjonowania samorządu jako wspólnoty władz i mieszkańców danej jednostki terytorialnej, współdziałających na rzecz jej rozwoju. Przykład miasta Radomia wskazuje, że budżet obywatelski wspomaga, uzupełnia, a niejednokrotnie zastępuje lub zwiększa skuteczność działania administracji publicznej. Przeprowadzone analizy mogą być wskazówką przy doskonaleniu realizacji budżetu Mazowsza. Słowa kluczowe: budżet obywatelski, społeczeństwo obywatelskie, partycypacja, współzarządzanie
Morbidity Patterns in Primary Care in Hong Kong: Protocol for a Practice-Based Morbidity Survey
Authors: Chen Julie Yun , Chao David , Wong Samuel Yeung-shan , Tse Tsui Yee Emily , Wan Eric Yuk Fai , Tsang Joyce Pui Yan , Leung Maria Kwan Wa , Ko Welchie , Li Yim-chu , Chen Catherine , Luk Wan , Dao Man-Chi , Wong Michelle , Leung Wing Mun , Lam Cindy Lo Kuen
Published: May 2022

Background

Up-to-date and accurate information about the health problems encountered by primary care doctors is essential to understanding the morbidity pattern of the community to better inform health care policy and practice. Morbidity surveys of doctors allow documentation of actual consultations, reflecting the patient’s reason for seeking care as well as the doctor’s diagnostic interpretation of the illness and management approach. Such surveys are particularly critical in the absence of a centralized primary care electronic medical record database.

Objective

With the changing sociodemographic profile of the population and implementation of health care initiatives in the past 10 years, the aim of this study is to determine the morbidity and management patterns in Hong Kong primary care during a pandemic and compare the results with the last survey conducted in 2007-2008.

Methods

This will be a prospective, practice-based survey of Hong Kong primary care doctors. Participants will be recruited by convenience and targeted sampling from both public and private sectors. Participating doctors will record the health problems and corresponding management activities for consecutive patient encounters during one designated week in each season of the year. Coding of health problems will follow the International Classification of Primary Care, Second Edition. Descriptive statistics will be used to calculate the prevalence of health problems and diseases as well as the rates of management activities (referral, investigation, prescription, preventive care). Nonlinear mixed effects models will assess the differences between the private and public sectors as well as factors associated with morbidity and management patterns in primary care.

Results

The data collection will last from March 1, 2021, to August 31, 2022. As of April 2022, 176 doctor-weeks of data have been collected.

Conclusions

The results will provide information about the health of the community and inform the planning and allocation of health care resources.

Trial Registration

ClinicalTrials.gov NCT04736992; https://clinicaltrials.gov/ct2/show/NCT04736992

International Registered Report Identifier (IRRID)

DERR1-10.2196/37334
Prevalence and Associated Factors of Problematic Use of Smartphones Among Adults in Qassim, Saudi Arabia: Cross-sectional Survey
Authors: Al-Mohaimeed Abdulrahman , Alharbi Mansour , Mahmud Ilias
Published: May 2022

Background

The Kingdom of Saudi Arabia (KSA) ranks third globally in smartphone use. Smartphones have made many aspects of life easier. However, the overuse of smartphones is associated with physical and psychosocial problems.

Objective

The aim of this paper is to estimate the prevalence and associated factors of problematic use of smartphones among adults in the Qassim region of KSA.

Methods

We enrolled 715 participants using cluster random sampling for this cross-sectional survey. We assessed the problematic use of smartphones using the short version of the Smartphone Addiction Scale.

Results

We estimated the prevalence of problematic smartphone use among adults at 64% (453/708). Multivariable logistic regression analysis suggested that students are 3 times more likely to demonstrate problematic use compared with unemployed individuals (P=.03); adults using more than five apps are 2 times more likely to demonstrate problematic use compared to those using a maximum of three apps (P=.007). Protective factors against problematic smartphone use include using apps for academic (odds ratio [OR] 0.66; P=.04) or religious needs (OR 0.55; P=.007) and having a monthly family income of 5001-10,000 SAR (Saudi Riyal; US $1300-$2700; OR 0.46; P=.01) or 10,001-20,000 SAR (US $2700-$5400; OR 0.51; P=.03) compared to the <1501 SAR (US $400) income group.

Conclusions

We reported a very high prevalence of problematic use of smartphones in KSA. Considering its negative impact on physical and psychosocial health, public health programs should develop preventive strategies.