bluuebunny/crossref_metadata_2025 huggingface dataset:
A cooperative management app for parents with myopic children wearing orthokeratology lens: Mixed methods pilot study (Preprint)
Authors: Sun Chi-Chin , Liao Gen-Yih , Liao Li-Ling , Chang Li Chun
Published: July 2021

BACKGROUND

Myopia is an underappreciated but profound public health problem. Orthokeratology (OK) lens wear is an effective modality to inhibit axial elongation in children with myopia. Willingness for a commitment from both parents and children contributes significantly to the success of the OK treatment and decreases the chance of complications due to non-compliance behaviors.

OBJECTIVE

The aim of this pilot study was to develop and assess the usability of a mobile application of OK lens by quantitatively and qualitatively evaluating parents with myopic children and eye care professionals (ECPs). We subsequently identified and resolved individual-specific usability issues to improve future implementation of the app protocol for parents and ECPs to collaboratively manage myopic children wearing OK lens.

METHODS

The app was developed and tested in 2020 using a co-design approach involving target users (parents with 7-13 myopic children), ECPs, designers, and app developers. A total of 36 parents with children who were given OK lens in an ophthalmology clinic were admitted to the study. Subsequently, prototype tests, two System Usability Scale (SUS) questionnaire surveys, and app engagement and app experience interviews were conducted during the three-month feasibility and utility assessment.

RESULTS

The app features include self-reported compliance documentation, analytics, personalized and generalized messages for compliance behaviors of orthokeratology lens. After the three-month trial period, the app demonstrated a usage rate of approximately 40 – 60 % among the 30 enrolled parents and was most often used prior to the follow-up visit. Although after the implementation of the app, there was no significant difference in compliance of wear and care, the incidence of comorbidities as well as the compliance with follow-up visits substantially improved. The average SUS scores at the first week and the third month were 54.6 and 82.0, respectively. Qualitative data suggested that parents were most satisfied with the app’s reminder and axial length recording functions, although it was recommended that the number of compliance behavior questions should be reduced to minimize the time required to complete the survey. In addition, whether the recording of the axial length data as well as the management and reminder for the follow-up visit should be completed by parents or ECPs remained controversial.

CONCLUSIONS

This is the first app developed to improve the parents’ compliance of myopic children with OK lens and assist ECPs and parents to collaboratively monitor and manage the wearing and caring of OK lens among myopic children as well as their follow-up visits. The study also highlighted the importance of interdisciplinary collaboration in the design, development, and validation of such an app.

CLINICALTRIAL

Nil
Development and Application of an Open Tool for Sharing and Analyzing Integrated Clinical and Environmental Exposures Data: Asthma Use Case (Preprint)
Authors: Fecho Karamarie , Ahalt Stanley C , Appold Stephen , Arunachalam Saravanan , Pfaff Emily , Stillwell Lisa , Valencia Alejandro , Xu Hao , Peden David B
Published: July 2021

BACKGROUND

The Integrated Clinical and Environmental Exposures Service (ICEES) serves as an open-source, disease-agnostic, regulatory-compliant framework and approach for openly exposing and exploring clinical data that have been integrated at the patient level with a variety of environmental exposures data. ICEES is equipped with tools to support basic statistical exploration of the integrated data in a completely open manner.

OBJECTIVE

This study aims to further develop and apply ICEES as a novel tool for openly exposing and exploring integrated clinical and environmental data. We focus on an asthma use case.

METHODS

We queried the ICEES open application programming interface (OpenAPI) using a functionality that supports chi-square tests between feature variables and a primary outcome measure, with a Bonferroni correction for multiple comparisons (α=.001). We focused on 2 primary outcomes that are indicative of asthma exacerbations: annual emergency department (ED) or inpatient visits for respiratory issues; and annual prescriptions for prednisone.

RESULTS

Of the 157,410 patients within the asthma cohort, 26,332 (16.73%) had 1 or more annual ED or inpatient visits for respiratory issues, and 17,056 (10.84%) had 1 or more annual prescriptions for prednisone. We found that close proximity to a major roadway or highway, exposure to high levels of particulate matter ≤2.5 μm (PM2.5) or ozone, female sex, Caucasian race, low residential density, lack of health insurance, and low household income were significantly associated with asthma exacerbations (P<.001). Asthma exacerbations did not vary by rural versus urban residence. Moreover, the results were largely consistent across outcome measures.

CONCLUSIONS

Our results demonstrate that the open-source ICEES can be used to replicate and extend published findings on factors that influence asthma exacerbations. As a disease-agnostic, open-source approach for integrating, exposing, and exploring patient-level clinical and environmental exposures data, we believe that ICEES will have broad adoption by other institutions and application in environmental health and other biomedical fields.
The Effectiveness of Online Learning in the Conditions of the Covid-19 Pandemic in Senior High School
Authors: Wardarita Ratu , Nisak Hairun
Published: July 2021

Pandemic covid-19 has disrupted the conventional learning process. So a solution is needed to answer these problems. Online learning is an alternative that can solve this problem. The research objective was to obtain an overview of the implementation of online learning at State Senior High School 1 Palembang, as an effort to reduce the spread of covid-19 in schools. The research subjects were students of class X IPA1 until X IPA6(100 students). Data were collected by an interview via zoom cloud meeting. Data analysis was performed using interactive analysis techniques by Miles & Huberman. The results showed that: (1) students already have the basic facilities needed to take part in online learning, (2) online learning has flexibility in its implementation and can encourage independent learning and motivation to be more active in learning, and (3) distance learning encourages the emergence of social distancing behavior and minimizes the appearance of student crowds so that it is considered to reduce the potential for the spread of Covid-19 in the school environment. Weak supervision of students, unstable mobile device signal, and high quota fees are challenges in online learning. Increasing independent learning, interest and motivation, courage to present ideas and questions are other advantages of online learning.
Bases conceptuales de la cirugía metabólica
Authors: Arana Reyes Juan Carlos , Cerón Rodríguez Fernando , Díaz Rodríguez Juan Javier , Vázquez Pelcastre Raúl , Aparicio Ponce Rodolfo , García Flores Rubén , Corona Bautista Antonio
Published: July 2021

The term Metabolic Syndrome (MS) has been used since its introduction in 2001 by the National Cholesterol Program (NCEP: ATP III). The concept has been discussed in the scientific literature for decades. The X Syndrome and other terms such as "death quartet" and insulin resistance syndrome have been used to describe the association between metabolic and cardiovascular risk factors. In Mexico, the prevalence of MS in the National Health and Nutrition Survey (Encuesta Nacional de Salud y Nutrición, ENSANUT) was 34% in 2000 and 41% in 2012. Lifestyle modifications along with increased physical activity, quitting smoking, and limiting alcohol consumption are essential for management and prevention because they play a central role in metabolic abnormalities. However, despite the large amount of medications available for diabetes, up to 50% of patients have been reported to fail to achieve adequate control goals, as defined by the American Diabetes Association (glycosylated hemoglobin <7%). In contrast, bariatric surgery (BS) has clearly confirmed that it contributes to improved beta cell function in patients with BMI > 35 kg / m 2 , as well as control of dyslipidemia and other metabolic disorders.
Keywords: Metabolic surgery; surgery and metabolic syndrome; syndrome X; mini gastric bypass; bypass of an anastomosis; Roux-en-Y bypass; bariatric surgery.
Obstrucción intestinal, complicación inusual por banda gástrica ajustable laparoscópica: reporte de caso
Authors: Chimal Juáreza María Fernanda , Fernández Rivera Enrique , Gaona Reyes Fabián , Rodríguez Reséndiz María del Pilar , Mora Muñoz Víctor Samuel
Published: July 2021

Background: The main goal of bariatric surgery is the reduction of Body mass index (BMI). Laparoscopic adjustable gastric band (LAGB) was the most popular method due to its relative advantages over others. Clinical case: A 44-year-old woman with abdominal pain and distension, with a history of LAGB placement had a diagnosis of intestinal occlusion secondary to a twist in the device tube, surgical management was given, the patient presented adequate evolution. Conclusion: The occlusion of the small intestine by the tube of the device is a serious and uncommon complication to be considered as a differential diagnosis in bariatric patients. Keywords: Bariatric surgery; complications; gastric band; bowel obstruction; obesity.
Isolation, Screening and Production of Bacterial Cellulase from Cow Dung
Authors: Gamathiya Niha B.
Published: July 2021

Cellulases are the most important industrial enzyme due to their potential application in various industries including pulp and paper, textile, laundry, biofuel production, food and feed industry, brewing and agriculture. The present study was carried out to isolate and characterize cellulase producing microorganisms from different cow dung samples. Four different cow dung samples were collected from variety of cows namely Gir, Holstein, Jersey and Desi and isolation and screening was done to check cellulase producing microorganisms. The obtained 11 isolates were screened for their cellulase activity by using CMC (carboxymethyl cellulose) agar medium. In the current study, 10 cellulase producing isolates were obtained and were characterized morphologically from which 8 isolates were found Gram negative and 2 were found Gram positive. All the 10 cellulase producers were further confirmed for their cellulase producing ability by performing turbidity test. Out of these 10 isolates, GN4 and HN2 with optical density 0.35 and 0.28, respectively were found to be best cellulase producer and were selected for cellulase enzyme production and other further studies. Botssh the isolates were tested for their enzymatic activities by performing DNSA method and protein estimation by Lowry’s method. Cellulase activities were found to be 7.33 µg/ml/min and 3.66 µg/ml/min and the total protein concentrations were found to be 40 µg/ml and 32 µg/ml for GN4 and HN2, respectively. Thus, dungs cow dung can be considered as the excellent source for cellulase producing bacteria.
Junk Filtering through Naive Bayesian Algorithm
Authors: Srivastava Anushka
Published: July 2021

As the world is seamlessly developing at a very high pace, we have been seeing enormous growth in various sectors of Technology. Networking has played a crucial part in the exchange of technological culture around the globe, and the Internet being the sole medium of Network enhancement has taken over every aspect of our society. Today, most of the professional communications are done through emailing. As far as email has proven to be an efficient, professional and easy way of communication, it also comes with the disadvantage of unwanted bulk bombarding of spam content. This has been a critical concern for email users. Consequently, it has become very difficult for spam filters to efficiently filter the unwanted emails, since nowadays emails are written in such a manner that any existing algorithm cannot give 100% accuracy in predicting spam. This paper deals with Naive Bayesian Classifier that is a Machine Learning algorithm for antispam filtering, which gives satisfactory results by automatically constructing anti-spam filters with extended conduct. The review over the researched performance of Naive Bayes algorithm is done by the investigations of Spam ham csv datasets. The performance of the algorithm is evaluated based on the accuracy, recall and precision it shows on the mentioned datasets. This technique gives 96-97% accuracy and 89% precision on the investigated dataset. The result also highlights that the content of the email and the number of instances of the dataset has an apparent effect on the performance of the algorithm.
Face Sketch Recognition Using Computer Vision
Authors: Meghana K S
Published: July 2021

Now-a-days need for technologies for identification, detection and recognition of suspects has increased. One of the most common biometric techniques is face recognition, since face is the convenient way used by the people to identify each-other. Understanding how humans recognize face sketches drawn by artists is of significant value to both criminal investigators and forensic researchers in Computer Vision. However, studies say that hand-drawn face sketches are still very limited in terms of artists and number of sketches because after any incident a forensic artist prepares a victim’s sketches on behalf of the description provided by an eyewitness. Sometimes suspect uses special mask to hide some common features of faces like nose, eyes, lips, face-color etc. but the outliner features of face biometrics one could never hide. Here we concentrate on some specific facial geometric feature which could be used to calculate some ratio of similarities from the template photograph database against the forensic sketches. The project describes the design of a system for face sketch recognition by a computer vision approach like Discrete Cosine Transform (DCT), Local Binary Pattern Histogram (LBPH) algorithm and a supervised machine learning model called Support Vector Machine (SVM) for face recognition. Tkinter is the standard GUI library for Python. Python when combined with Tkinter provides a fast and easy way to create GUI applications. Tkinter provides a powerful object-oriented interface to the Tk GUI toolkit.
Online Food Ordering Management System
Authors: Dhiman Karan
Published: July 2021

The main purpose of the Online Food Ordering Management System is to use it in the food-service industry. This feature helps hotels and restaurants to increase their online food ordering systems. Customers can choose from a wide range of food menu items within just a few minutes. In today’s modern food business, it's also able to deliver fast and easily to a customer’s place. The work presented as Online Food Ordering Management System simplifies the ordering process. The proposed solution presents a user interface and changes the menu to include all available options, creating customer work easier. Allows customers to order any item that they like and adjust the quantity of the food item. The order confirmation is displayed to the customer on the Homepage of the website. The order is put to the queue, updated across both the database and the admin panel, and provided in real-time. This system aids the staff with checking over orders in real-time and executing them effectively and easily with few errors. Here, the customer can also reserve a table at a restaurant of his/her choice and will get the confirmation of their reserved table on the homepage of our website.
Conversation Engine for Deaf and Dumb
Authors: K J Monika
Published: July 2021

Deaf and hard hearing people use linguistic communication to exchange information between their own community and with others. Sign gesture acquisition and text/speech generation are parts of computer recognition of linguistic communication. Static and dynamic are classified as sign gestures. Both recognition systems are important to the human community but static gesture recognition is less complicated than dynamic gesture recognition. Inability to talk is taken into account to be a disability among people. To speak with others people with disability use different modes, there are number of methods available for his or her communication one such common method of communication is linguistic communication. Development of linguistic communication recognition application for deaf people is vital, as they’ll be able to communicate easily with even people who don’t understand language. Our project aims at taking the fundamental step in removing the communication gap between normal people, deaf and dumb people using language.
Evaluasi Pengembangan Tata Ruang Wilayah Terhadap Bencana Tanah Longsor di Kecamatan Cisarua, Kabupaten Bogor
Authors: Ramadhan Aditya , Muhamad Kurniawan
Published: July 2021

Pengembangan wilayah yang terjadi di suatu daerah sejatinya harus sesuai dengan perencanaan tata ruang agar tejadinya sinergi antara kelestarian, rasa aman, dan kesejahteraan dalam kualitas hidup penduduknya. Kecamatan Cisarua termasuk wilayah di sisi selatan Kabupaten Bogor serta berbatasan dengan Kabupaten Cianjur yang memilki topografi dataran tinggi sehingga diasumsikan dengan zona rawan bencana tanah longsor. Penelitian ini bertujuan untuk membuat peta kerawanan tanah longsor berdasarkan tiga klasifikasi yaitu rendah, sedang, dan tinggi serta mengevaluasi perencaan pola ruang khususnya area permukiman terhadap peta kerawanan tanah longsor tersebut. Metode yang digunakan dalam penelitian ini adalah skoring dan pembobotan. Selanjutnya, dilakukan teknik tumpang susun (overlay) dengan memanfaatkan teknologi sistem informasi geografi menggunakan lima variabel fisik yaitu kondisi geologi, kemiringan lereng, curah hujan, penggunaan lahan, dan jenis tanah. Berdasarkan temuan penelitian yang telah dilakukan, Kecamatan Cisarua memiliki zona kerawanan rendah seluas 20,84 Km2 atau sebesar (31,24%), zona kerawanan sedang seluas 32,21 Km2 atau sebesar (48,28%), dan zona kerawanan tinggi seluas 13,66 Km2 atau sebesar (20,48%). Pada evaluasi pola ruang terhadap zona rawan tanah longsor, tidak terdapat zona kerawanan tinggi dalam deliniasi kawasan permukiman. Kesimpulannya, rencana pola ruang khususnya permukiman yang telah dibuat dan ditetapkan oleh pemerintah sudah tepat untuk pengembangan wilayah di Kecamatan Cisarua.
Response to Covid-19 Crisis: Recommendations and Health Policy Changes
Authors: Aseel Bin Sawad  , Fatema Turkistani
Published: July 2021

The World Health Organization (WHO) declared the pandemic status of coronavirus disease of 2019 (COVID-19). The necessity for social distancing has prompted states to make policy changes. These policy changes are in line with the policies and recommendations set by the WHO, the Centers for Disease and Control Prevention (CDC), the United States Department of Health  and Human Services  (HHS), the Centers  for Medicare  and Medical Services  (CMS),  the Kaiser  Permanente,  the National  Institutes  of  Health  (NIH),  the  United  States  Food  and  Drug  Administration  (FDA),  and  the  American  Medical Association (AMA). The aim of this study is to discuss and analyze the effectiveness of many organizations in responding to the COVID-19 crisis. Three processes were involved in conducting the narrative review: (1) a search was conducted through the websites of eight organizations (CDC, HHS, CMS, Kaiser Permanente, NIH, WHO, FDA, and AMA), (2) Selection of relevant information  related to the responses  taken by the eight organizations  between  January 21, 2020 and April 24, 2020 were included, (3) the information selected from the websites of the eight organizations were recorded, summarized, and integrated in this paper.COVID-19 is a health problem that needs to be approached in a collaborative manner. All eight organizations that have taken action against the further spread of the virus. The different policy changes and/or recommendations from the eight organizations have one common ground and that is the necessity for social distancing. To prevent overcrowding in hospitals and in other healthcare facilities, the organizations have decided to expand telehealth coverage. In Conclusions Health-related and policy-issuing organizations provided policies that are aligned with one another in order to contain the spread of COVID-19.
Effect of Ultrasound Therapy and Cryotherapy over Taping Technique in Patients with Acute Lateral Ankle Sprain
Authors: Dr. Ramamurthy  , Dr. Jibi Paul  , Dr. Hepsibah Sharmil  , Dr. Sathya P
Published: July 2021

The sudden twisting of ankle which overstretches the ligaments to torn or sprain around the ankle joint can lead to pain and swelling. Pain and swelling is one of the major causes of concern in patients with acute lateral ankle sprain while performing physical and daily activity. The study aim was to find the effect of ultrasound therapy and cryotherapy over taping technique among patients with acute lateral ankle sprain. A total of 30 subjects with acute lateral ankle sprain participated in this study. Group A was given ultrasound therapy with cryotherapy for 30 minutes; Group B was given taping technique additional to ultrasound and cryotherapy. Pre and post test was done after 10 sessions of treatment. The outcome was measured for the participants by VAS score. Student’s t-test, Mann Whitney test, Wilcoxon signed rank test were used to analyze data in this study. Group A and B have shown significant improvement after treatment. Comparative study found Group B,  had  significant changes by ultrasound therapy, cryotherapy and ankle taping technique over the Group A with P<0.001, on reducing pain, swelling  and  improving    earlier  active  performance.  On  the  basis  of  the  result,  the  study concluded  that  treatment  with cryotherapy, ultrasound therapy and taping technique is better compared with cryotherapy and ultrasound therapy, and has more effect in reducing pain, swelling and improving earlier active physical performance.
Reliability of Cobb’s Angle in a Measurement of Kyphosis – A Meta–Analysis
Authors: G.Vaishnavi  , S.Preethi  , G, Tharani  , V.Rajalaxmi  , K.Kirupa  , S.M.Divya  Mary  , RNV.Deepthi  , A.Sangeetha  , Rajashri.R
Published: July 2021

This study aimed at analyzing the literature systematically  on the reliability of Cobb’s angle in measurement  of kyphosis. Cobb’s angle is the most widely used measurement to quantify spinal deformity. Kyphosis is the spinal disorder in which an excessive outwards of the spine results in an abnormal rounding of the upper back. Cobb’s angle used as standard measurement to determine and trackthe progression of scoliosis andkyphosis. Hence the purpose of the meta-analysis is to analyze the reliability of Cobb’s angle in a measurement of kyphosis Systematic searches in PubMed, Science direct, Google scholar, Cochrane library, Research Gate for systematic review was done. Research article and review article were selected within the published 1999 – 2020. The study design is Meta-analysis study of Analytical type. Study quality was done by PEDro Scale The study duration is about 4 months. A Meta-analysis was conducted  by using Medical software to obtain a summary estimate of the standardized  mean difference  and 95% confidence limit. 100 articles taken for review in which finally 35 articles were summarized. Almost all the study shows that there was a highly significant difference  on measurement  of kyphosis using COBB’S angle. Outcome of measurement  has excellent reliability with the small range of standard error of measurement.  Cobb’s measurement  had excellent reliability when used to measure kyphosis. The findings confirm the significance and the ease of using this method.
Experiential QI Activity for Residents to Improve Women’s Preventive Services
Authors: Kindratt Tiffany , Day Philip G. , Blower Jessica , Yun Olivia , Gimpel Nora
Published: July 2021

Introduction: The Accreditation Council for Graduate Medical Education (ACGME) requires family medicine residents to complete a quality improvement (QI) project. There is a need for more QI training activities to be shared to meet this requirement. Our objective was to describe an activity for residents to improve women’s preventive health services in an underserved clinic. Specific aims were to determine: (1) how women’s receipt of preventive services compared to benchmarks, (2) physician and staff knowledge of the process and barriers to receiving services, and (3) whether an intervention to increase awareness among physicians and staff improved preventive services.
Methods: Residents (N=30) evaluated charts (N=505) to determine receipt of mammograms, pap tests, colon cancer screenings, and pneumonia vaccines. We compared estimates to existing clinic benchmarks. We presented initial (preintervention) results to physicians and staff at clinic team meetings. We collected perceptions of processes and barriers to preventive services. Preintervention methods were replicated (N=100) and results were compared (postintervention).
Results: Preintervention, mammograms (72%) and Pap tests (65%) were lower than clinic benchmarks. Most (81%) women ages 65 and older received a pneumonia vaccine; however, this was lower than the national Healthy People 2020 goal. Fear, knowledge, and scheduling were identified as top barriers. Post-intervention, there was a statistically significant increase in Pap tests (P=.0013).
Conclusion: This activity trained residents how to impact their practice through QI methods and can be used in other programs as a foundation for developing basic QI initiatives. Future efforts should focus on evaluating barriers to preventive services from the patient perspective.
UTILIZATION OF ACTIVE COMPOUNDS IN TUMERIC (Curcuma longa) AS ANTIOXIDANT HERBAL
Authors: Aulia Reviana , Ernah Ernah , Mubarok Syariful
Published: July 2021

Turmeric (Curcuma longa) is a plant that has many benefits. Most people use turmeric as a cooking spice, food coloring, or as traditional medicine. Traditional medicine is needed as an alternative method in medical world. At present, a lot of research has been done to develop the use of turmeric. The active compound in turmeric is diferuloylmethane (1,7-bis (4-hydroxy-3-methoxyphenyl) -1,6-heptadiene-3,5-dione) or often called curcumin. Curcumin is a compound that has many benefits. Curcumin can be used as an antioxidant, anti-inflammatory, antibacterial, and antiobesity. The purpose of this review journal is to discuss several studies related to the potential of the active component in turmeric. This journal discusses the benefits of active compounds in turmeric as an antioxidant, anti-inflammatory, antibacterial, and antiobesity.
Use of Heuristics during the clinical decision process in from family physicians in real conditions.
Authors: Aguilar Carmen Fernández , Martín-Martín José-Jesús , Minué-Lorenzo Sergio , Ajuria Alberto Fernández
Published: July 2021

Rationale, aims and objectives: The available evidence on the existence
and consequences of the use of heuristics in the clinical decision
process is very scarce. The purpose of this study is to measure the use
of the Representativeness, Availability and Overconfidence heuristics in
real conditions with Primary Care physicians in cases of dyspnea and to
study the possible correlation with diagnostic error. Methods: A
prospective cohort study was carried out in 4 Primary Care centers in
which 371 new cases or dyspnea were registered. The use of the three
heuristics in the diagnostic process is measured through an operational
definition of the same. Subsequently, the statistical correlation with
the identified clinical errors is analyzed. Results: In 9.97% of the
registered cases a diagnostic error was identified. In 49.59% of the
cases, the physicians used the representativeness heuristic in the
diagnostic decision process. The availability heuristic was used by
82.38% of the doctors and finally, in more than 50% of the cases the
doctors showed excess confidence. None of the heuristics showed a
statistically significant correlation with diagnostic error. Conclusion:
The three heuristics have been used as mental shortcuts by Primary Care
physicians in the clinical decision process in cases of dyspnea, but
their influence on the diagnostic error is not significant. New studies
based on the proposed methodology will allow confirming both its
importance and its association with diagnostic error.
Diversity of EU habitat types is correlated with geography more than climate and human pressure
Authors: Cervellini Marco , Musciano Michele Di , Zannini Piero , Fattorini Simone , Jiménez-Alfaro Borja , Agrillo Emiliano , Attorre Fabio , Angelini Pierangela , Beierkuhnlein Carl , Casella Laura , Field Richard , Fischer Jan-Christopher , Genovesi Piero , Hoffmann Samuel , Irl Severin D. H. , Nascimbene Juri , Rocchini Duccio , Steinbauer Manuel , Vetaas Ole Reidar , Chiarucci Alessandro
Published: July 2021

Aims: Habitat richness, i.e. the diversity of ecosystem types, is a
complex, spatially explicit aspect of biodiversity, which is affected by
bioclimatic, geographic and anthropogenic variables. The distribution of
habitat types is a key component for understanding broad-scale
biodiversity and for developing conservation strategies. To test which
factors are related with habitat richness we used EU habitat
distribution data to answer the following questions: i) how do
bioclimatic, geographic, and anthropogenic variables affect habitat
richness? ii) which category is the most important? iii) how do
interactions among these variables influence habitat richness and which
combinations produce the strongest interactions? Study area: European
Union (excluding Greece) plus the United Kingdom. Methods: We used the
distribution maps of 233 terrestrial habitat types defined by the
European Environmental Agency, to calculate habitat richness for the EU
10 km x 10 km grid map. We then investigated how environmental variables
affect habitat richness, using generalized linear models, generalized
additive models and boosted regression trees. Results: The main factors
associated with habitat richness were geographic variables, with
negative relationships observed for both latitude and longitude, and a
positive relationship for terrain ruggedness. Bioclimatic variables
played a secondary role, with habitat richness increasing slightly with
annual mean temperature and overall annual precipitation. An interaction
between anthropogenic variables was important: the combination of
increased landscape fragmentation and increased population density
strongly decreased habitat richness. Main conclusions: This is the first
attempt to disentangle spatial patterns of habitat richness at the
continental scale, as a key tool for protecting biodiversity. The
diversity of European habitats is correlated withgeography more than
climate and human pressure, reflecting a major component of
biogeographical patterns similar to the drivers observed at the species
level. The interaction between anthropogenic variables highlights the
need for coordinated, continental-scale management plans for
biodiversity conservation.
Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of severe endometriosis patients
Authors: Jiang Yanping , Wang Lu , Peng Yaqin , Qin Jian , Tan Aili , Wang Shujun
Published: July 2021

Endometriosis is a chronic inflammatory disorder resulting in pelvic
pain and infertility. The role of T helper 17 (Th17) cells in
endometriosis remains elusive. In this study, through detecting CXCR3,
CCR4, CCR10, CCR6, interleukin-17 Receptor E (IL-17RE), and CD27, live
RORγt-and-IL-17A-expressing Th17 cells were distinguished and sorted
from peritoneal fluid (PF) of patients with stage III and IV
endometriosis. Furthermore, we found that IL-17RE and CD27 were the
labels of heterogeneous PF Th17 subsets, i.e. IL-17RE-CD27- subset,
IL-17RE+CD27- subset, and IL-17RE+CD27+ subset. The former two subsets
expressed higher IL-17A, GM-CSF, and IL-22 and were more proliferative
than the latter subset. RNA-Seq analysis on IL-17RE+ Th17 subset and
IL-17RE- Th17 subset revealed up-regulation of genes involved in
oxidative phosphorylation and electron transport chain in IL-17RE+ Th17
subset relative to IL-17RE- Th17 subset. Consistently, the IL-17RE+ Th17
subset produced more adenosine triphosphate (ATP) and reactive oxygen
species (ROS) than IL-17RE- Th17 subset. In conclusion, this study
provides a novel method to detect and isolate live PF Th17 cells from
endometriosis patients and unveils the functional and metabolic
heterogeneity of PF Th17 subsets. Therefore, it sheds light on the
elucidation of molecular mechanisms that modulate the function of
pathological Th17 cells in endometriosis.
Associations between Demographics and Quality of Life in Children in the First Year of Cancer Treatment
Authors: Raybin Jennifer , Hendricks-Ferguson Verna , Cook Paul , Jankowski Catherine
Published: July 2021

Symptom distress and decreased quality of life (QOL) among children with
cancer are well documented. Research is emerging on the child’s voice in
QOL-symptom reports, but existing QOL questionnaires are burdensome and
objective biologic markers are lacking. We examined children’s symptoms
and QOL from parent and child perspectives and compared the results to
one biologic marker (body posture). A cross-sectional secondary analysis
of prospective data from children receiving creative arts therapy
explored potential associations among demographics with and between QOL
measures (PedsQL, Faces Scale, posture). Children (n = 98) ranged in age
from 3-17 years (M = 7.8) and were in the first year of cancer
treatment. No significant associations were found among the child’s sex,
race/ethnicity, socioeconomic status (SES), or distance from hospital
and total PedsQL. Older age was associated with worse total PedsQL,
pain, nausea, worry, and posture (all ps < .05). Greater worry
(β = 0.51) and worse posture (β = 0.41) were the QOL variables most
strongly correlated with older age. Poorer posture was associated with
worse child PedsQL (total score, nausea, treatment anxiety, cognitive)
and parent PedsQL (pain, nausea). Worse scores on the Faces Scale,
PedsQL, and posture were all correlated (rs = .21 - .39, all ps
< .05). Interventions to improve QOL could target nausea,
worry, and older patients. Accuracy and interpretation of symptom
distress in children is problematic. The Faces Scale and posture may be
suitable, readily obtained measures of QOL in pediatric oncology that
hold promise.
The Domino Effect of Perceived Stakeholder Pressures on Eco-Controls
Authors: Henri Jean-François , Journeault Marc , Rodrigue Michelle
Published: July 2021

We examine how managers orchestrate their eco-control package in reaction to different perceived environmental stakeholder pressures. Using survey data from Canadian manufacturing firms, our results show that environmental pressures perceived from societal stakeholders have a greater influence on the integration of environmental objectives into strategic planning than pressures perceived from business stakeholders. This suggests that business stakeholders act as a force that mostly maintains the scope of strategic environmental orientations, while societal stakeholders act as a force that mostly expands the scope of strategic orientations by stimulating further consideration of environmental issues as strategic objectives. The integration of environmental objectives in strategic planning stimulates a domino effect within the eco-control package, where the adaptation of strategic objectives leads to greater mobilization of other eco-controls. This domino effect represents successive effects among components of the eco-control package, revealing how stakeholder pressures play a role in stimulating multi-layered changes in eco-control mobilization.
Considerations for Transgender People With Diabetes
Authors: Moverley Joy , Loebner Sarah , Carmona Brent , Vuu David
Published: July 2021

This article offers clinicians resources and an overview for supporting gender-diverse individuals with diabetes. Creating a supportive office environment is crucial to providing optimal diabetes care for patients who identify as transgender.
SCO-267, a GPR40 Full Agonist, Stimulates Islet and Gut Hormone Secretion and Improves Glycemic Control in Humans
Authors: Nishizaki Harunobu , Matsuoka Osamu , Kagawa Tomoya , Kobayashi Akihiro , Watanabe Masanori , Moritoh Yusuke
Published: July 2021

SCO-267 is a full agonist of the free fatty acid receptor 1 (GPR40),
which regulates the secretion of islet and gut hormones. In this phase 1 study,
we aimed to evaluate the clinical profile of single and multiple once-daily
oral administration of SCO-267 in healthy adults and patients with diabetes. Plasma
SCO-267 concentration was seen to increase in a dose-dependent manner after administration,
and its plasma exposure was maintained for 24 h. Repeated dose did not alter
the pharmacokinetic profile of SCO-267 in healthy adults. SCO-267 was generally
safe and well tolerated at all evaluated single and multiple doses. Single and repeated doses of SCO-267
stimulated the secretion of insulin, glucagon, glucagon-like peptide 1,
glucose-dependent insulinotropic polypeptide, and peptide YY in healthy adults.
Furthermore, a single dose of SCO-267 stimulated the secretion of these
hormones, decreased fasting hyperglycemia, and improved glycemic control during
an oral glucose tolerance test in patients with diabetes, without inducing
hypoglycemia. This study is the first to demonstrate the clinical effects of a GPR40
full agonist. SCO-267 is safe and well tolerated and exhibits once-daily oral
dosing potential. Its robust therapeutic effects on hormonal secretion and glycemic control
make SCO-267 an attractive drug candidate for the treatment of diabetes.
Development of English Writing Skills through Blended Learning among ESL Learners in Malaysia
Authors: Hassan Isyaku , Madarina Abdul Rahman Ayuni , Nazri Latiff Azmi Mohd
Published: July 2021

Developing writing proficiency is complex as students need to master specific rules and acquire certain skills. This complexity often obstructs students’ interest and eventually affects their comprehension and performance in language learning. Research has highlighted the significance of English as a Second Language (ESL), particularly in the Malaysian context. This study, therefore, aims to evaluate the effectiveness of blended learning in developing English writing skills, particularly among ESL learners at a Polytechnic in Malaysia. The study adopted quasi-experimental analysis in which pre-test and post-test were used as data-gathering instruments. The data were gathered from a purposive sample of 60 ESL students separated into an experimental group and a control group. The data were analyzed using the Mann-Whitney U test via the Statistical Package for Social Sciences (SPSS). The findings showed that blended learning is significantly effective in developing writing performance among ESL students in the selected institution. Further analysis revealed a slight improvement among students who learned through the traditional approach. This study highlights useful findings that could be useful in designing English curriculums, particularly in higher institutions. However, this experiment focuses on students’ performance, further research may explore instructors’ practices in Malaysian higher intuitions.
Digital transformation dynamics of the russian economy: an international comparative analysis
Authors: Minashkin Vitaly G. , Egorova Elena A. , Prokhorov Pavel E.
Published: July 2021

In this study, trend analysis of the availability and ICT use in organizations was carried out using a broader range of indicators in the long term, which made it possible to identify patterns of digital transformation (DT) and the corresponding stage of digital maturity of the economy. Digital economic activity, the role of information, and the value of data have increased, which affected the trends in the use of the Internet for the exchange of electronic products. In terms of practical application, the results of the analysis can be used in studies devoted to modeling and predicting DT trends on the considered indicators of ICT use in organizations to implement a deeper and more comprehensive study of the nature of the trends and patterns of DT development.
Formation of research skills in university non-linguistic training profile students during the implementation of a professionally oriented distance course in a foreign language
Authors: Bakurova Yelena Nikolaevna , Parshutkina Tatyana Alekseevna , Kudryavtseva Olga Mikhailovna , Chernovol Mikhail Petrovich
Published: July 2021

The research purpose is to identify the level of development of research skills in non-linguistic training profile students in the process of professionally oriented teaching of a foreign language and to summarize the data obtained in the experimental work.  The research was carried out based on the author’s distance course “Foreign language for specific purposes in scientific research”, comprising three modules, using electronic testing with the application of the computer knowledge testing program MyTestXPro11.0. The sample comprised 250 students studying English and German. In order to verify the data obtained and the conclusions drawn, a comparative analysis of the test results of the control and experimental groups was carried out. The authors revealed the level of development of research skills in non-linguistic training profile students. So, at the stage of the ascertaining experiment, the average score of successfully completed tasks was 8.9 (44.7%), and at the stage of the control experiment, respectively, 16.7 (83.3%).
THE EFFECT OF PERCEIVED SOCIAL MEDIA MARKETING ACTIVITIES ON BRAND LOYALTY THROUGH BRAND CONSCIOUSNESS AND VALUE CONSCIOUSNESS ON VIVO SMARTPHONE
Authors: . Chrein Yonathan Yoel , Ellitan Lena , . Robertus Sigit Haribowo Lukito
Published: July 2021

This research was conducted to determine the influence of Social Media Marketing Activities on Brand Loyalty through Brand Consciousness and Value Consciousness in Vivo smartphone. This research is casual research. The sampling technique uses non probability sampling by purposive sampling by purposive sampling. Respondents in this study were Vivo smartphone users and   followed one of the Vivo smartphone social media.  While the sample is 100 respondents. Data in this study were collected by distributing questionnaires using Google Form (online). The data analysis technique used is Structural Equation Modeling (SEM) using the SmartPLS 3 program.  The result in this research indicate that:  Perceived Social Media Marketing Activities has a positive and significant effect on Brand Loyalty, Brand Consciousness and Value Consciousness. Brand Consciousness has a positive and significant effect on Brand Loyalty. Value Consciousness has no effect Brand Loyalty. Perceived Social Media Marketing Activities through Brand Consciousness and Value Consciousness has no effect on Brand Loyalty in Vivo smartphone users
Analisis Pengembangan Kurikulum Bahasa Arab di MTS Surya Buana Kota Malang
Authors: Imamuddin Imamuddin , Nuraidah Nuraidah , Huda Miftahul , Daroini Slamet
Published: July 2021

Sering dengan pergantian menteri pendidikan maka berganti pulalah kurikulum pendidikannya. Kurikulum tidak luput dari perombakan kurikulum sebelumnya hingga pada kurikulum 2013 saat ini. Akibat perubahan kurikulum tersebut, mata pelajaran bahasa Arab ikut terkena imbasnya. Begitu pula evaluasai dari kurikulum dari bahasa Arab tersebut. Tujuan penelitian ini untuk mengetahui pelaksanaan kurikulum bahasa Arab berupa visi misi dan tujuan, materi, metode, media, pendekatan, sumber, serta evaluasi kurikulum yang digunakan. Penelitian ini menggunakan penelitian kualitatif dengan desain deskriptif. Teknik pengumpulan datanya menggunakan wawancara, observasi, dan dokumentasi. Teknik analisis datanya menggunakan reduksi data, paparan data, dan kesimpulan atau verifikasi. Pengecekan keabsahan data menggunakan triangulasi, perpanjangan keikutsertaan, dan ketekunan pengamatan. Hasil penelitiannya yaitu ada keterkaitan yang sangat erat antara Visi, Misi dan Tujuan di MTS Surya Buana dengan Kurikulum 2013 yang diberlakukan oleh pemerintah saat ini, pelaksanaan kurikulum bahasa Arab menggunakan kurikulum 2013 dengan pendekatan seintifik dan disesuaikan dengan KI dan KD nya, metode yang diterapkan terbagi menjadi metode umum dan khusus, media yang digunakan beragam, dan evaluasi pembelajaran mencakup 4 komponen pokok yaitu spiritual, sosial, pengetahuan, dan keterampilan.Abstract : Often with the change of the minister of education, the education curriculum changes. The curriculum did not escape from the previous curriculum reshuffle to the current 2013 curriculum. As a result of the curriculum change, Arabic subjects were also affected. Likewise the evaluation of the curriculum from the Arabic language. The purpose of this study was to determine the implementation of the Arabic language curriculum in the form of vision, mission and objectives, materials, methods, media, approaches, sources, and evaluation of the curriculum used. This study uses qualitative research with a descriptive design. Data collection techniques using interviews, observation, and documentation. The data analysis technique uses data reduction, data exposure, and conclusions or verification. Checking the validity of the data using triangulation, an extension of participation, and persistence of observations. The results of the research are that there is a very close relationship between the Vision, Mission and Goals at MTS Surya Buana with the 2013 Curriculum imposed by the current government, the implementation of the Arabic language curriculum uses the 2013 curriculum with an intuitive approach and is adapted to its KI and KD, the methods applied are divided into general and specific methods, the media used are varied, and the evaluation of learning includes 4 main components, namely spiritual, social, knowledge, and skill.
ANALISIS POLA PERJALANAN DAN AKTIVITAS WISATAWAN INDONESIA MILENIAL KE SINGAPURA
Authors: Savira Kiki , Suwena I Ketut , Sudana I Putu
Published: July 2021

Millennial recently became a trend in tourism. Millennials were born in 1980 to 2004, they grew up as digital natives, and have a consumptive nature where they do not hesitate to spend a certain amount of money to please themselves such as traveling, both at home and abroad. One of the countries that is a favorite destination for millennial Indonesian tourists when traveling abroad is Singapore. In addition to its close location, Singapore also has modern urban tourism attractions and technologies that match the millennial character. These facts became the background of this research; characteristics, travel patterns, and activities of millennial Indonesian tourists while traveling in Singapore. This research uses descriptive qualitative data analysis. The sample was determined purposively, totaling 105 millennial tourists from Indonesia who had traveled to Singapore. The data collection technique was done by using an online questionnaire. The results showed that the characteristics of millennial Indonesian tourists in Singapore were female, aged 21 to 25 years, unmarried, had a Bachelor's degree and were a private employee. Most tourists are first time traveling to Singapore, stay in Singapore 3 to 7 days, come and travel with family, arranging their own trips, using the internet as a source of information and mostly using MRT (Mass Rapid Transit) as a mode of transportation while traveling in Singapore. There are two millennial Indonesian tourists’ travel patterns while traveling in Singapore, which are chaining loop pattern, and base site pattern. The most common millennial Indonesian tourists’ activities in Singapore is doing culinary tourism (75%), the second is shopping (66%), and the third is enjoying local cultures (51%).