bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of a novel eunicellane synthase unveils the relationship between stereochemistry and flexibility among eunicellanes
Authors: Li Jinfeng , Chen Bao , Fu Zunyun , Mao Jingjing , Liu Lijun , Chen Xiaochen , Zheng Mingyue , Wang Chang-Yun , Wang Chengyuan , Guo Yue-Wei , Xu Baofu
Published: December 2023

Eunicellane diterpenoids, containing a typical 6,10-bicycle, are bioactive compounds widely distributed in marine corals as well as rarely discovered in bacteria and plants, attracting the attention of scientists in the pharmaceutical field. The intrinsic macrocycle exhibits innate structural flexibility resulting in dynamic conformational changes. However, the intriguing mechanisms controlling flexibility remain unknown. To shed light on this, a genome mining-based discovery of a terpene synthase, MicA, that is responsible for the biosynthesis of a non-flexible eunicellane skeleton, was presented, enabling us to propose a feasible theory that configurations of bridging carbons and their adjacent double bond govern flexibility in eunicellane structures. Notably, isotopic labeling experiments, together with density functional theory calculations, revealed that bacteria-derived MicA follows the catalytic route mainly as coral-derived eunicellane synthase through consecutive 1,14-ring closure, two 1,2-hydride shifts, 1,10-cyclization, and final deprotonation. Furthermore, structural analysis of the artificial intelligence-based MicA model and mutational studies provided an insightful basis for the enzymatic mechanism, featuring a new 2E-configured eunicellane scaffold formation by mutant MicAV220A. Finally, parallel studies of all eunicellane synthases in nature discovered to date, including 2Z-GGPP incubations and DFT-based Boltzmann population computations, revealed that a trans-fused bicycle with a 2Z-configured alkene restricts conformational flexibility resulting in a non-flexible eunicellane skeleton. Our findings presented a new eunicellane synthase, providing new insights into the eunicellane formation and the theory governing flexibility among eunicellane skeletons.
Perovskite nanoparticles Cs4PbBr6 and CsPbBr3: synthesis, analysis and peculiar optical properties
Authors: Son Alexandra , Kozyukhin Sergey , Gushina Valeria , Egorova Anastasia , Arkhipenko Alexandra , Korotkova Natalia , Sadovnikov Alexei , Bert Nikolai , Shandarov Yuri , Ivanov Denis , Petrov Nikolai
Published: December 2023

All-inorganic perovskite CsPbBr3 and Cs4PbBr6 nanoparticles are being intensively studied due to their unique properties and wide range of applications; however, however, the nature of their optical properties is not yet fully understood due to the difficulty of synthesis of single-phase nanoparticles. In this article we describe the features of the synthesis of single-phase particles and the results of their chemical and phase analysis. Using data on nanoparticle concentrations, we experimentally determined the absorption coefficient for both phases. It has been shown that nanoparticles of CsPbBr3 and Cs4PbBr6 perovskites exhibit features of such optical characteristics as photoluminescence, optical band gap, including the region of weak absorption (Urbach tail), and action spectrum also. The experimental results can be explained within the framework of existing ideas about the band gap structure for perovskite materials.
Combining low-cost electronic structure theory and low-cost parallel computing architecture
Authors: Steinbach Pit , Bannwarth Christoph
Published: December 2023

The computational efficiency of low-cost electronic structure methods can be further improved by leveraging heterogenous computing architectures. The software package TeraChem has been developed since 2008 to make use of graphical processing units (GPUs) for the acceleration of quantum chemical calculations. Here, we present the implementation of three low-cost methods, namely HF-3c, PBEh-3c, and the recently introduced ωB97X-3c. We show that these can benefit in terms of performance when combined with “consumer grade” GPUs by leveraging the mixed precision integral handling in TeraChem. Furthermore, these methods can be combined with the hh- TDA formalism to give new and efficient low-cost excited states methods, which are benchmarked for the description of lowest vertical excitation energies in this work. All in all, the combination of these efficient electronic structure theory methods with affordable highly parallelized computing hardware provides an optimal computational and monetary cost to accuracy ratio.
1,4-Dihydropyridine Anions as Potent Single-Electron Photoreductants
Authors: Gallage Prasadi , McKee Mary , Pitre Spencer
Published: December 2023

Organic anions offer a promising route for promoting difficult single-electron reductions, owing to their strongly reducing excit-ed states that can be accessed under visible light irradiation. This report describes the use of simple 1,4-dihydropyridine anions as a general platform for promoting single-electron photoreductions. In the presence of a mild base, 1,4-dihydropyridines were shown to effectively promote the hydrodechlorination and borylation of aryl chlorides and the photodetosylation of N–Tosyl aromatic amines under visible light irradiation.
Społeczeństwo obywatelskie w klasowym zwierciadle
Authors: Leśniewicz Kacper , Radiukiewcz Anna
Published: December 2023

Idea społeczeństwa obywatelskiego zajmuje istotne miejsce w debacie publicznej w Polsce. W artykule proponujemy spojrzenie na ten dyskurs z uwzględnieniem problematyki klas społecznych. Z jednej strony uznajemy bowiem, że – jak każdy sposób interpretowania rzeczywistości społecznej – tak i ten zajmujący się kwestią obywatelskości jest społecznie warunkowany. Z drugiej strony twierdzimy, że proces ten można traktować jako element symbolicznego wytwarzania czy też odtwarzania różnic klasowych. Jedną z istotnych w tym kontekście praktyk jest krytyka społeczna, której uprawianiu sprzyja również wartościujący charakter samego pojęcia społeczeństwa obywatelskiego. Nasze badanie opiera się na analizie dyskursu elit symbolicznych, diagnozujących na łamach prasy stan społeczeństwa obywatelskiego w Polsce w okresie 1989–2019. Wnioski z analiz wskazują na kluczowe znaczenie w tych diagnozach rozróżnienia na aktywnych i nieaktywnych oraz obywatelskich i nieobywatelskich. Jak konkludujemy, obrazy oparte na tych rozróżnieniach są częstokroć tworzone z wykorzystaniem opisów różnic stricte klasowych, choć ich autorzy nie zawsze odnoszą się wprost do pojęcia klasy.
Changes in searching behaviour of CSL transcription complexes in Notch active conditions
Authors: Baloul Sarah , Roussos Charalambos , Gomez-Lamarca Maria , Muresan Leila , Bray Sarah
Published: December 2023

During development cells receive a variety of signals, which are of crucial importance to their fate determination. One such source of signal is the Notch signalling pathway, where Notch activity regulates expression of target genes through the core transcription factor CSL. To understand changes in transcription factor behaviour that lead to transcriptional changes in Notch active cells, we have probed CSL behaviours in real time, using in vivo Single Molecule Localisation Microscopy. Trajectory analysis reveals that Notch-On conditions increase the fraction of bound CSL molecules, but also the proportion of molecules with exploratory behaviours. These properties are shared by the co-activator Mastermind. Furthermore, both CSL and Mastermind, exhibit characteristics of local exploration near a Notch target locus. A similar behaviour is observed for CSL molecules diffusing in the vicinity of other bound CSL clusters. We suggest therefore that CSL acquires an exploratory behaviour when part of the activation complex, favouring local searching and retention close to its target enhancers. This change explains how CSL can efficiently increase its occupancy at target sites in Notch-On conditions.
Everyday Life of Irkutsk Residents in 1918: The Czechoslovak Regiment in the City and the Attitude of Local Residents Towards the Czechs
Authors:   Irkutsk State University, Saranchuk A. V.
Published: December 2023

The purpose of this article is to examine the influence of the Czechoslovak Regiment on the daily life of Irkutsk residents. The article gives an idea of the changes that the soldiers of the Czechoslovak regiment made to the daily life of Irkutsk residents during the Civil War, how different segments of the population reacted to their entry into the city, how they treated the soldiers of the regiment. The article also discusses the issue of the relationship of the local Irkutsk population with soldiers. Much attention in this context is paid to the relationship between soldiers and female representatives of Irkutsk, who showed special interest in them. At the end of the article, conclusions are given that the arrival of soldiers of the Czechoslovak regiment was perceived quite positively by Irkutsk residents and had a great impact on their daily lives.
Relación entre los estilos parentales y la regulación emocional en adolescentes
Authors: Castañeda-Alape Gabriela Andrea , López-Mojica Gabriela Lucía , Guerra-Báez Sandra Patricia
Published: December 2023

Aunque se ha documentado la influencia del estilo parental en el desarrollo socioemocional de niños y adolescentes, no existe información definitiva sobre su relación con la regulación emocional. Este estudio tuvo como objetivo analizar la relación entre los estilos parentales y el nivel de regulación emocional en adolescentes latinoamericanos de 12 a 18 años. Para ello, se utilizó un diseño transversal correlacional en una muestra de 60 adolescentes y sus respectivos padres y se midieron las variables utilizando tres instrumentos: cuestionario de características sociodemográficas, cuestionario de dimensiones y estilo de crianza (PSDQ) y escala de dificultades en regulación emocional (DERS). A partir del análisis mediante prueba U de Mann-Whitney, prueba de Kruskal[1]Wallis y análisis ANOVA de un factor, se determinó que no había una relación significativa entre las principales variables investigadas; sin embargo, se encontró una asociación entre la frecuencia de discusiones informadas por los adolescentes y la dificultad en la regulación emocional. A mayor frecuencia de discusiones, mayor dificultad en la regulación emocional. Para el desarrollo de otros estudios, se recomienda replicar este con una muestra mayor, teniendo en cuenta las percepciones de los estilos de crianza tanto de los padres como de los adolescentes.
USO DA INTELIGÊNCIA ARTIFICIAL NO ENSINO DE FÍSICA: POTENCIALIDADES E DESAFIOS
Authors: Albuquerque Jader Cristiano Magalhães de , Dores Jorge Lucio Rodrigues das
Published: December 2023

O objetivo deste artigo é validar o método e a sequência didática que será utilizada na dissertação do Mestrado Nacional Profissional de Ensino de Física sobre aplicação de Inteligências artificiais como ferramentas auxiliares para o ensino de relatividade restrita para a terceira série do ensino médio. Utilizando-se os referenciais teóricos Paulo Freire, Marco Silva e Morán, o projeto foi metodologicamente desenvolvido a partir de uma pesquisa qualitativa, de natureza aplicada, com objetivo exploratório e procedimento experimental. O resultado foi a criação de um vídeo utilizando-se palavras-chave do livro didático e geradas pela Inteligência Artificial chat GPT e Studio D-ID. A análise do método utilizado mostrou que as metodologias ativas aprendizagem baseada em problemas e aprendizagem baseada em equipe podem ser exploradas pelo professor utilizando o livro texto em conjunto com a Inteligência Artificial, bem como ratifica a importância da figura docente como orientador do processo, devido questões éticas na utilização desta tecnologia digital.
Communication Using the Storytelling Method Improves Knowledge in Implementing Health Protocols for School-Age Children
Authors: Astarani Kili , Mahanani Srinalesti , Yusiana Maria Anita
Published: December 2023

The continuous increase in confirmed cases of COVID-19, especially in children aged 6â€“18, has prompted the government to provide advice to the public on how to implement health protocols and have clean and healthy living habits, especially in terms of implementing health protocols. One of the approaches that can be taken to provide knowledge to children is by communicating using storytelling. By storytelling or telling stories about implementing health protocols, children can better accept and digest what is given. The purpose of this study was to analyze the effect of communication using the storytelling method on knowledge of implementing school-aged children's health protocols at SD Kalipang 4 Grogol, Kediri district. The research design used was the pre-experiment using the one-group pretest-post-test design method. The population of this study was school-age children at SD Kalipang 4 Grogol, Kediri Regency, with a total of 26 students. The independent variable used is storytelling on the application of the health protocol, and the dependent variable is knowledge of the implementation of the health protocol. The sampling technique used is total sampling. By using a knowledge questionnaire about implementing health protocols. Data analysis used the Wilcoxon statistical test to analyze the effect of communication using the storytelling method on knowledge of implementing health protocols. Conclusion Communication using the storytelling method affects school-age children's knowledge about implementing health protocols at SD Kalipang 4 Grogol, Kediri, with a significance value of 0.000 (p=0.05)
Comorbidity and Fatality Among Covid Patients: A Hospital Based-Retrospective Cohort Study
Authors: Sari Yeni Kartika , Nurmawati Thatit , Santoso Joko Ivnu , Kusnianto Maratus Sholichah Fitriah Hajar
Published: December 2023

People with comorbid diseases have a high risk of contracting COVID-19, because the immune system has decreased, thus increasing the risk of transmission of COVID-19 and even potentially increasing the risk of fatality. This study aimed to determine the comorbidity and mortality among COVID-19 confirmed cases during May to September, 2021. The study was a retrospective cohort with secondary data from the COVID-19 with in Hospital report from May to September, 2021, with a total sample of 178. We extracted demographic and clinical data, including hospital outcomes (discharge or death). The result of the research showed that the respondents separated in to two groups, half of them are patients with comorbidity (89 patients) and the rest are patients non comorbidity. From 89 patients with comorbidity, 62 % were died and 38 % were discharged. The most comorbidites were 67,4% diabetes mellitus, 33% hypertension. The fatality rate of COVID-19 patients was 34% devided to 61,8% were comorbidity patients and 5,5% were non comorbidity. The comorbidity related to fatality rate of COVID-19 patientâ€™s (p=0.000). It is important for society to avoid and control comorbid factors of COVID-19
Experience of Covid-19 Survivors in Relieving Symptoms of Anosmia
Authors: Agustin Amelia Diah , Mugianti Sri , Martiningsih Wiwin
Published: December 2023

The high stigma of the community and public compliance in implementing health protocols can hamper the reduction of COVID-19 cases. One of the symptoms of COVID-19 is anosmia. The purpose of this study was to find out the experiences of survivors of Covid-19 to relieve symptoms of anosmia. The data collection method in this case study is through in-depth interviews. Data collection was carried out on January 10 2022-February 10 2022. The research design used a qualitative case study with 9 participants from Sumberjo Village who experienced symptoms of anosmia during COVID-19. Data collection tools use mobile phones and stationery. The sampling technique used is snowball. The results showed that all participants tried to eliminate the symptoms of anosmia. Four themes were found regarding the experiences of Covid-19 survivors in relieving anosmia symptoms, theme 1) efforts made to relieve anosmia symptoms were PHBS, use of pharmacological and nonpharmacological drugs, and olfactory training. Theme 2) the feelings felt when confirmed are still enthusiastic, afraid, anxious, and worried. Theme 3) Environmental responses to confirmed COVID-19 patients, including positive responses, are support systems in the family and environment, and negative responses are social stigma. Theme 4) symptoms of anosmia if confirmed with COVID-19 are respiratory tract disorders, muscle stiffness, thermoregulation, sleep disturbance, and fatigue. To relieve the symptoms of mia in the form of nasal irrigation with 0.9% NaCl solution, it is necessary to carry out tests at a later date, even though there are already researchers in several hospitals
The Relationship between Anxiety Levels and Blood Sugar Levels in the Elderly
Authors: Listianasari Ajeng , Wulandari Ning Arti , Anugrah Wimar
Published: December 2023

The increasing age, the more problems faced both physically and mentally such as loneliness, anxiety and depression. The prevalence of anxiety in the elderly is increasing. The increased release of the hormones cortisol and epinephrine in someone who is experiencing anxiety can affect an increase in gluconeogenesis and glycogenolysis which results in an increase in blood sugar levels. This study was to analyze the relationship between anxiety levels and blood sugar levels in the elderly. The research design uses a cross sectional approach. The sample for this research was 87 respondents who were taken by purposive sampling from 111 elderly people.Â  The results of the Pearson correlations test showed that there was a relationship between anxiety and blood sugar levels in the elderly with a p value = 0.000 (<0.05). Therefore, the elderly can control their anxiety to reduce the risk of increasing blood sugar levels which have an impact on the health of the elderly
Literature Review: The Relationship of Knowledge and The Selection of Long-Acting Contraceptive Methods
Authors: Dwiyani Tatik , Ansakawirus Raisyah , Muthitulsalimah Mutiara Ayu , Rahmadi Agus
Published: December 2023

The participation or involvement of Birth control program acceptors in selecting and using long- acting contraceptive methods (LACMs) in Indonesia still needs to be higher. The factors contributing to the minimal participation of KB acceptors in the selection or use of LACMs include the low level of knowledge among acceptors regarding the use of LACMs. The objective of the study was to explain the relationship between KB acceptors' knowledge and the selection of LACMs. This literature review used a systematic literature review of 10 articles related to the topic, which have been screened. Ten journals that had been selected say that all agree that there is a relationship between knowledge and LACMs. According to the researcher and the data obtained, it could be concluded that there was a match between the researcher's literature review results and current theory, as well as previous research results
Pencegahan Luka Tekan Pada Pasien Hidrosefalus Di Ruang Pediatric Intensive Care Unit
Authors: Rahmayanti Wa Ode , Erika Kadek Ayu , Amin Ariyati , Hariati Suni , Fadilah Nur , Yusuf Mukhtar
Published: December 2023

Anak penderita hidrosefalus dengan penurunan kesadaran rentan mengalami gangguan integritas kulit, seperti luka tekan akibat tirah baring lama, imobilisasi dan terpasang alat medis. Studi kasus ini bertujuan mengevaluasi intervensi pencegahan luka tekan pada pasien hidrosefalus di ruang Pediatric Intensive Care Unit RSUP Dr. Wahidin Sudirohusodo Makassar. Metode yang digunakan adalah single case design dengan instrumen pedoman pencegahan luka tekan dari National Pressure Injury Advisory Panel pada subjek studi kasus. Pengumpulan data dilakukan dengan observasi dan intervensi serta dokumentasi mulai 19-22 Juni 2023. Hasil studi kasus menunjukkan skala Braden Q berada pada skor 15 di hari pertama dan kedua serta skor 14 di hari ketiga dan keempat (risiko luka tekan sedang). Intervensi pemeriksaan kulit didapatkan terjadi perubahan suhu menjadi normal, tidak ada ruam kulit, tidak ada indurasi, tidak edema dan tidak nyeri akibat tekanan serta tidak ada luka akibat peralatan medis. Selain itu, tidak ada luka pada area tonjolan tulang setelah pemberian posisi miring kanan dan kiri serta pemberian bantalan sebagai penyangga dapat mencegah risiko luka tekan. Penilaian dan standar dari manajemen nutrisi adalah tidak terjadi penurunan berat badan dan tidak ada tanda-tanda dehidrasi. Dapat disimpulkan skor skala Braden Q berada pada risiko sedang sehingga diberikan intervensi sesuai pedoman.
DIGITALIZING SCULPTURES: A PHOTOGRAMMETRY IMPLEMENTATION TOWARDS ANCIENT MATARAM STATUARIES IN CENTRAL JAVA
Authors: Winaya Atina , Purnawibawa R. Ahmad Ginanjar , [n/a] Brahmantara , Effendi Dian , Murdihastomo Ashar , Bismoko Dimas Seno , Nastiti Titi Surti , Indradjaja Agustijanto , Syofiadisna Panji , Susetyo Sukawati , Santoso Probo , Ekowati Dian Rahayu , Utomo Bambang Budi , Banindro Aris
Published: December 2023

The implementation of digital technology in cultural heritage in Indonesia started to develop in the past decade. However, Indonesia's iconography studies have not optimized to utilize these advanced approaches. While in some other countries, iconographic documentation is upgrading to an advanced method, such as recording objects in 3D form and archiving it into secure digital data, thus the data more natural and realistic in three-dimensional documentation. It also catches and records the shape from all perspectives to bring neither a specific nor comprehensive observation. Therefore, it can extend the analysis for interpretation and preservation purposes. This article discusses the implementation of photogrammetry towards sculpture objects in Indonesia. The object selection went to several sculptures from the Ancient Mataram period in Java, which ruled from the 8th to 10th centuries AD. Close-range photogrammetry successfully generates the sculpture data into three-dimensional digital form. The results could support the Ancient Mataram sculptures studies in particular and improve Indonesia's iconography studies in general.

Keywords: photogrammetry, sculptures, statues, iconography, ancient Mataram
Effect of climate, anther morphology and pollination syndrome on pollen availability in Penstemon
Authors: Rodríguez-Peña Rosa A , Wolfe Andrea D.
Published: December 2023

Traditionally, pollen presentation is thought to be a function of pollinator type and visitation frequency. However, despite the repeated observation that pollen presentation is influenced by flower morphology and abiotic factors, these aspects have been little studied in the wild. Here, we evaluated the effect of climate, anther morphology, and pollination syndrome on anther dehiscence time (the length of time an anther takes to fully dehisce after a flower opens). We recorded anther dehiscence time in twelve species of Penstemon including the four major anther types and the two most common pollination syndromes. We also conducted an experiment to measure the effect of humidity and temperature on anther dehiscence. We found that anther morphology was correlated with anther dehiscence time. Anthers with wide openings take the longest time to dehiscence. These results provide some support for the hypothesis that anther dehiscence time has evolved to decrease pollen wastage. Contrary to the assumption that bird-pollinated species have simultaneous pollen presentation, hummingbird-pollinated species had longer anther dehiscence time than most bee-pollinated species. The experiment revealed that high humidity and low temperature increase anther dehiscence time. Our results suggest that pollen presentation is influenced by anther morphology, pollination syndrome, and the physical environment. Optimal pollen presentation presumably maximizes conspecific pollen transfer and reduces pollen thieving.
Two Trials of Professor Vrzalík. Collaborant or victim of communist justice?
Authors: Plachý Jiří
Published: December 2023

The study presents the life story of one of the pineers of the Czech fascist movement and a representative of the First Republican Vlajka, Jan Vrzalík (1904−1971), who in the first half of the war tried to engage publicly in the Protectorate political scene. However, he was not found criminally responsible during the post-war retributions. He was arrested in 1959 and subsequently sentenced to an unconditional scene for anti-state activities, part of which he served in prison, although he was completely blind at the time.
Vzdělanci mezi dělníky. Reflexe sociální otázky v letech 1845–1849 na příkladu vývoje myšlenkového světa a politického osudu dvou knihtiskařů (Stephan Born a Karl Scherzer)
Authors: Raška Jakub
Published: December 2023

Následující studie si klade za cíl postihnout myšlenkový vývoj dvou příslušníků „hledající generace“ intelektuálně a politicky dospívající ve 40. letech 19. století. Sleduje reflexi sociální otázky dvou vyučených knihtiskařů, novinářů a v revoluci i politiků Stephana Borna (1824–1898) a Karla Scherzera (1821–1903). Studie vychází z předpokladu, že se sociální otázka krátce před rokem 1848 stala jedním z ústředních témat středoevropského veřejného prostoru, které do velké míry přispělo ke konkretizaci obsahů formujících se politických ideologií. V dobovém kontextu je sledován náhled na sociální otázku obou aktérů v letech 1845–1849, kdy se tématem intenzivně zabývali. V chronologickém sledu jsou analyzovány jednotlivé etapy jejich života a intelektuálního vývoje ve sledovaném období. V první části je pozornost věnována jejich rodinnému původu a intelektuálním zdrojům, ve druhé části jsou sledovány jejich první pokusy o novinářskou reflexi sociální otázky a ve třetí části jejich názory a osudy v revoluci, kdy oba stanuli na špici organizačních snah dělníků.
Za kolik? Vývoj cen rumunského obilí v přístavech na dolním Dunaji (1829–1853)
Authors: Constantin Cristian
Published: December 2023

Jeden z podoborů ekonomické historie se zabývá vývojem cen. Tento článek představuje zevrubné údaje pro rekonstrukci statistických řad potřebných pro studium vývoje cen obilí v přístavech na dolním Dunaji ve druhé čtvrtině 19. století. Nedávný výzkum umožnil identifikaci několika pramenů, které umožňují analýzu cenových křivek rumunské pšenice a kukuřice obchodované v Moldávii a Valašsku.
Rekontextualizace identifikačních znaků a přetvoření krajiny s jejími prvky. Poznámky a svědectví ze slovenského venkova
Authors: Dragnea Dorina
Published: December 2023

Článek, zaměřený na slovenský venkov, poskytuje etnografický vhled do rekontextualizace forem identifikačních znaků a způsobů přetváření krajinných prvků v emickém a etickém pojetí. Výzkum přibližuje pohled zahraniční badatelky na vybraný kulturní terén a skupinu. Pozornost je zaměřena na současné aspekty krajiny a její etnografické prvky, jak byly zaznamenány in situ. Tyto prvky jsou zkoumány ze synchronního a chronologického hlediska.
Evaluation of the in vitro cryopreservative performance of Juniper berry oil (Juniperus communis) on frozen-thawed bull semen
Authors: Güngör Şükrü , Yeni Deniz , İnanç Muhammed Enes , Türkmen Ruhi , Tuncer Pürhan Barbaros , Gülhan Mehmet Fuat , Avdatek Fatih , Taşdemir Umut
Published: December 2023

This study aimed to reveal the effects of juniper (Juniperus communis) berry oil (JB) when added to the Tris extender, on bull (Holstein) sperm motility characteristics, abnormal sperm ratio, DNA fragmentation and some oxidative stress markers. The pooled ejaculate was divided into five equal parts as control (C) and Tris diluent containing 25, 50, 100, 200 μg/ml JB. Diluted semen was incubated at 4 °C for 4 h and then frozen in liquid nitrogen (−196 °C). After freezing-thawing, motility characteristics were determined using a sperm analyzer system. The results showed that the 25 μg/ml dose of JB had an improving effect on overall sperm motility (P < 0.05). The total abnormal spermatozoa ratio was not significantly different between the groups (P > 0.05). The JB25 and JB50 groups had higher DNA integrity than the other groups (P < 0.05). This finding was supported by low malondialdehyde levels (P < 0.05). Especially the 25 μg/ml dose of JB was found to have a remedial effect on DNA integrity, as well as increasing progressive and total motility rates. This study has revealed new information on the effects of JB on bull semen cryopreservation. Juniper berry oil may be used as an antioxidant in bull semen freezing.
Foreign body in the dog pericardium – a case report
Authors: Nováková Veronika , Lorenzová Jana , Nečasová Andrea , Nývltová Ivana
Published: December 2023

This case report describes the diagnosis and subsequent surgical therapy of a foreign body in the pericardium in a young Small Münsterland Pointer. The patient was referred to our clinic for exercise intolerance and suspicion of pericardial effusion identified via thoracic radiography. Diagnostics including blood analysis and diagnostic imaging were made during the patientʼs hospitalisation. Presence of a foreign body passing from the stomach to the pericardium was suspected. To confirm the localisation of the foreign body, computed tomography was performed. Surgical treatment included an intercostal thoracotomy with partial bilateral pericardiectomy followed by laparotomy. The foreign body was surgically removed. The patient did not experience any complications during the postoperative period and was able achieve a full recovery.
Assessment of urinary cystine concentration in dogs in the Czech Republic
Authors: Kovaříková Simona , Maršálek Petr , Blahová Jana , Kučera Jaroslav , Vrbová Kateřina , Večerek Vladimír
Published: December 2023

The prevalence of cystinuria as an inborn error of metabolism in dogs is unknown. The purpose of this study was to evaluate the prevalence of cystinuria in dogs of various breeds in the Czech Republic. In total, 326 voided urine samples from client owned dogs were obtained. Samples were divided into four groups according to the breed - Irish Terriers (n = 58), Dachshunds (n = 67), French Bulldogs (n = 64) and a group of various breeds (n = 137). Urinary cystine concentration was measured using liquid chromatography/mass spectrometry, urinary creatinine concentration was determined by Jaffe method. Samples with urinary cystine concentrations above 178 µmol/g creatinine were considered as cystinuric. Urinary cystine concentration above the upper limit was found in 71 dogs (21.8%) with significantly higher incidence in intact males of Irish Terriers. In general, cystinuria was more common in intact males. In Irish Terriers, Dachshunds, French Bulldogs, German Shorthaired Pointer, Pomeranian, and Fox Terrier, cystinuria was identified in females. Cystinuria appears to be a relatively common finding in dogs in the Czech Republic, with some breeds being more affected. The finding of cystinuria in two female Irish Terriers calls into question the classification of cystinuria in this breed as androgen dependent only. The detection of cystinuria in related dogs suggests that other individuals in the same family should be examined as part of the management of a cystinuric patient.
Incidence of spontaneous tumours in guinea pigs: a retrospective study of 153 cases
Authors: Nešpor Jindřich , Heczková Kateřina , Škorič Miša
Published: December 2023

The aim of this study was to investigate the incidence of spontaneous tumours in guinea pigs in biopsy and necropsy samples in the monitored period (2016–2022) on a representative number of cases and to determine their occurrence in relation to age and sex of the animals. A total of 204 samples from various pathological lesions were examined, while 153 cases (75.00%) were true tumours and 51 cases (25.00%) were pseudotumorous non-neoplastic lesions. The distribution of the incidence of true neoplasms in relation to sex was uneven. In the examined group, more neoplasms were diagnosed in males (n = 88, 57.52%) compared to females (n = 65, 42.48%). The mean age of guinea pigs with diagnosed tumour in our group was 4.2 years. Thyroid adenocarcinoma was the most frequent tumour. The majority of thyroid tumours (67.86%) were diagnosed in animals aged 4–5 years, as a significant result in terms of incidence in this age range, as well as a predisposition to tumour formation in males (78.57%). Mammary gland tumours occurred in the age range of 2–7 years, with a mean age of incidence of 4.7 years. In all cases, these were malignant variants and showing a significant higher incidence in males, in the age range of 4–5 years. The processing of a representative number of samples and epidemiological data on the incidence of spontaneous tumours in guinea pigs can contribute to the overall expansion of knowledge about this topic in veterinary medicine.
Prospective 25-year surveillance of prion diseases in France, 1992 to 2016: a slow waning of epidemics and an increase in observed sporadic forms
Authors: Denouel Angéline , Brandel Jean-Philippe , Peckeu-Abboud Laurène , Seilhean Danielle , Bouaziz-Amar Elodie , Quadrio Isabelle , Oudart Jean-Baptiste , Lehmann Sylvain , Bellecave Pantxika , Laplanche Jean-Louis , Haik Stéphane
Published: December 2023

Background

Prion diseases are rare, fatal disorders that have repeatedly raised public health concerns since the early 1990s. An active prion disease surveillance network providing national level data was implemented in France in 1992.

Aim

We aimed to describe the epidemiology of sporadic, genetic and infectious forms of prion diseases in France since surveillance implementation.

Methods

We included all suspected cases notified from January 1992 to December 2016, and cases who died during the period with a definite or probable prion disease diagnosis according to EuroCJD criteria. Demographic, clinical, genetic, neuropathological and biochemical data were collected.

Results

In total, 25,676 suspected cases were notified and 2,907 were diagnosed as prion diseases, including 2,510 (86%) with sporadic Creutzfeldt–Jakob disease (sCJD), 240 (8%) genetic and 157 (6%) with infectious prion disease. Suspected cases and sCJD cases increased over time. Younger sCJD patients (≤ 50 years) showed phenotypes related to a distinct molecular subtype distribution vs those above 50 years. Compared to other European countries, France has had a higher number of cases with iatrogenic CJD after growth hormone treatment and variant CJD (vCJD) linked to bovine spongiform encephalopathy (second after the United Kingdom), but numbers slowly decreased over time.

Conclusion

We observed a decrease of CJD infectious forms, demonstrating the effectiveness of measures to limit human exposure to exogenous prions. However, active surveillance is needed regarding uncertainties about future occurrences of vCJD, possible zoonotic potential of chronic wasting diseases in cervids and increasing trends of sCJD observed in France and other countries.
Cerebral arterial gas embolism (CAGE) during open water scuba certification training whilst practising a controlled emergency swimming ascent
Authors:   Department of Hyperbaric Medicine, Fiona Stanley Hospital, Murdoch, Australia, Banham Neil , da Silva Elisabete ,   Department of Hyperbaric Medicine, Fiona Stanley Hospital, Murdoch, Australia, Lippmann John ,   Australasian Diving Safety Foundation, Melbourne, Australia
Published: December 2023

We report the case of a 23-year-old male novice diver who sustained cerebral arterial gas embolism (CAGE) during his open water certification training whilst practising a free ascent as part of the course. He developed immediate but transient neurological symptoms that had resolved on arrival to hospital. Radiological imaging of his chest showed small bilateral pneumothoraces, pneumopericardium and pneumomediastinum. In view of this he was treated with high flow normobaric oxygen rather than recompression, because of the risk of development of tension pneumothorax upon chamber decompression. There was no relapse of his neurological symptoms with this regimen. The utility and safety of free ascent training for recreational divers is discussed, as is whether a pneumothorax should be vented prior to recompression, as well as return to diving following pulmonary barotrauma.
Hypoxic loss of consciousness in air diving: two cases of mixtures made hypoxic by oxidation of the scuba diving cylinder
Authors:   Department of Hyperbaric Medicine, Military Teaching Hospital, Sainte-Anne, Toulon, France, Druelle Arnaud , Daubresse Lucille ,   Department of Hyperbaric Medicine, Military Teaching Hospital, Sainte-Anne, Toulon, France, Mullot Jean U ,   Navy Laboratory for Analysis Surveillance and Expertise, 83000 Toulon, France, Streit Hélène ,   Medical Center of ATRIA, 90 000 BELFORT, France, Louge Pierre ,   Acute Medicine Department, Hyperbaric Medicine Unit, Geneva University Hospitals, rue Gabrielle-Perret-Gentil 4, 1205 Geneva, Switzerland
Published: December 2023

Without an adequate supply of oxygen from the scuba apparatus, humans would not be able to dive. The air normally contained in a scuba tank is dry and free of toxic gases. The presence of liquid in the tank can cause corrosion and change the composition of the gas mixture. Various chemical reactions consume oxygen, making the mixture hypoxic. We report two cases of internal corrosion of a scuba cylinder rendering the respired gas profoundly hypoxic and causing immediate hypoxic loss of consciousness in divers.
Reflexivity 3. Breaking out the Reflexive Loop to Decolonise Practice
Authors: Simon Gail
Published: December 2023

Reflexivity guides our everyday relational ethics but always takes place within a cultural loop. We find what we recognise. Reflexive practice is a commitment to ethical practice but it isn’t a safety net which stops us from reproducing the same dominant discourses of who or what counts and structures which maintain inequalities.
In this paper I explore the question, “How can systemic therapists develop reflexivity in their practice to intentionally change and connect personal struggle with wider systems which reproduce power and inequality?” I describe some differences between what I call Reflexivity 1, Reflexivity 2 and Reflexivity 3 to show the impact of ideology on theory, method and what we (think we) notice and act on.
I share some reflexive questions, stories from practice and research and examples of wider systemic activism. These working ideas are a response to concerns that the clinic and the organisations which host them are oppressive, colonial structures which limit the progress members of the public can make within them and restrict opportunities to develop practice-theory which takes into account and challenges social, historic and material inequalites and injustice.
The Relationships of Otolith Dimensions (Length-Breadth) with Weight and Total Length of Greater Forkbeard (Phycis blennoides (Brünnich, 1768)) Captured from northeastern Mediterranean Sea
Authors: GİRGİN Hülya , BAŞUSTA Nuri
Published: December 2023

The greater forkbeard, Phycis blennoides is captured by commercial trawler, has minor commercial value in Türkiye. This study is the first knowledge on otolith biometry-fish size relationships of Phycis blennoides living in the northeastern Mediterranean Sea. A total of 202 the greater forkbeard individuals were caught by commercial bottom trawl at a depth of 200 to 400 m in the northeastern Mediterranean. Minimum-maximum total length and weight of obtained fish specimens were found as 16.9-38.7 cm and 31.06-415.0 g for females and 16.3-38.3 cm and 27.14-504.08 g for males respectively. The difference of the total length and weight between the females and males of P. blennoides was statistically insignificant (P>0.05). The determination coefficient value showed that there were a moderate relationships between total length-right and left otolith lengths, total length-right and left otolith breadths.
Occurrence of Homola barbata (Fabricius, 1793) (Decapoda, Brachyura) in Finike Bay (Türkiye, Eastern Mediterranean Sea)
Authors: KOÇAK Cengiz , AYDIN Coşkun Menderes , ÜNLÜOĞLU Aydın
Published: December 2023

Bottom trawl samplings in Finike Bay revealed the existence of a brachyuran crab species, Homola barbata (Fabricius, 1793). H. barbata has been recorded only fourth time in Turkish waters, up to now. The existence of this rare species is recorded herein for the first time from the Finike Bay. It is the westernmost record of H. barbata on the Mediterranean coast of Türkiye. A distribution map of H. barbata in the eastern Mediterranean Sea is also presented, together with photographs of it.
ENHANCING THE PERCEPTION OF AN URBAN AREA - A CASE STUDY OF BATALA CITY
Authors: Arora Nishant , Kumar Utkarsh
Published: December 2023

The city image defines how people see and recall aspects in urban environments. The most distinguishing components of urban landscape, classified as pathways, nodes, boundaries, districts, and landmarks, form people's mental representations of the city. Because to urbanisation, India's historic cities are in grave danger. The heritage zones are essential components of the city's fabric, contributing to the city's image. Apart from possessing magnificent examples of traditional architecture, these heritage neighbourhoods serve as cultural and social hubs for the city, providing citizens with a sense of worth. The development process over the last few decades has had such an impact on historic towns that evidence of their historic worth is being destroyed forever. This historical zone is plagued by numerous concerns and problems. People come to Batala to enjoy the city's Punjabi culture and traditions. Maximum tourist visit to the city during "BABE DA VIVAH". This cultural zone is a one-of-a-kind place where the ambiance blends both old and modern architecture, and it is a multifunctional area offering a mix of history, educational, entertainment, residential, culinary, and so on. This area has a rich history, as evidenced by the presence of four major ancient monuments: Shamsher Khan Tomb, Jal Mahal, Baring Chaple, and Maharaj Sher Singh Palace. During the British Raj, this region was also frequented by British people. This cultural district has a number of issues, including a lack of a pedestrian area, criminal activity, a change in space use, changes in scale and land use, and so on. Furthermore, Batala city has no space for social interaction or recreation; there is only 0.81% of recreational area in the city, which is almost negligible; thus, there is an urgent need to create one cultural district in the city, which will not only help the city's residents socialise but will also attract tourists, resulting in the preservation of heritage monuments and increased revenue for the city.
FUSION OF MODERN INTERIOR STYLE AND NORTH INDIAN TRADITIONAL INTERIOR STYLE
Authors: Sharma Manshi , Goel Manika , Choudhary Deepashree
Published: December 2023

The interior design style of different states of India has been the subject of considerable research in disciplines such as art forms, handicrafts and cultural identities of interior styles. But modernization of the world has created a rage of creating minimalistic spaces, this caused the need for the fusion of traditional into modern interior style. This helped in retaining our culture and preserving the traditional practices as well as artworks. The research elaborated different ways to fuse elements like space, texture and colour from North Indian traditional into Modern interior style. The fusion is supported with the help of six case studies of houses with fused interior design style from North Indian states. The paper concludes with the identification of different ways in which designers and homemakers can fuse traditional into modern interior styles.
Similarity Appearance of Parents with Progeny of Lombok Local Cantaloupe (Cucumis melo var. Cantalupensis) and Melon (Cucumis melo L.)
Authors: SHOLİHATİN Rosyita , ASHARİ Sumeru , KUSWANTO Kuswanto
Published: December 2023

Crosses between local lombok cantaloupe and melon have produced the first progeny (F1). The F1 have a similar appearance to their parents. This study used two similarity assessments based on qualitative and quantitative traits. Qualitative characters are said to have similarities if their phenotypic appearance resembles one or both parents. The similarity of qualitative characters is visually observed using the munsell plant tissue color book and penetrometer. Meanwhile, the quantitative characters are said to have an appearance resembling one or both parents if the standard error line at the histogram between parents and offspring overlaps. In addition, analysis of gene action, heterosis, heterobeltiosis, and the maternal effect was carried out on quantitative character to obtain genetic information for producing superior local lombok cantaloupe varieties. The results of this study showed several changes in the appearance of F1 in qualitative and quantitative characters. The qualitative characters of F1 resemble the female parent, while the quantitative characters do not resemble both parents. Genetic information about potential ratio, heterosis, heterobeltiosis, and maternal effect varied. Gene action is dominated by potency ratio partial dominance and overdominance. Heterosis occurred in all treatments, while heterobeltiosis did not occur in all treatments. The maternal-effect was obtained on fruit weight, fruit diameter, and fruit length characters.
Youth Authoritarianism in Korean Democracy: What Makes the Youth in a Consolidated Democracy Withdraw Support for Democracy?
Authors:   Institute of Korean Studies, f f
Published: December 2023

Why do young adults in Korea appear to reject the democratic system and embrace with authoritarianism? Employing a specially designed survey, this study examined the influence of the models of extreme economic hardship, social threat, fairness, and populism using the structural equation model. Thus, the determinants of the authoritarian system were found to be multidimensional and somewhat at odds with each other in the direction of causation. The threat of economic hardship and intolerant attitudes toward North Korea and minorities were important factors that led young adults to support authoritarian regimes. Nevertheless, young adults who are critical of the fairness of democracy in Korea continue to support the democratic system. Young adults who are critical of representative democracy and oriented toward populism showed the same preference. This result provides the hopeful prospect that Korea may not join the recent trend of deconsolidation and further reauthoritarianism in the near future.
Characteristics of the seminal quality of infertile patients in the City of Quito.
Authors: Guamán-Gualpa William , Arias-Bustamante José , Villacis-Vaca Diego , Vasquez-Maya Carlos , Cuesta-Garzón Daniela , Luna-Prieto Maiella
Published: December 2023

Introduction: Male infertility has a complex etiology and one of the determining factors is the quality of the semen. The evaluation of this factor is carried out using a spermogram; where the two components of semen are analyzed: the sperm; in number, mobility and morphology, as well as the seminal fluid produced by the accessory glands in charge of nourishing the sperm and interacting with the female genital tract.
Objective: To determine the characteristics of the semen, the most frequent alterations and the age effect on the seminal quality of patients who come to an infertility consultation in an assisted reproduction center in the city of Quito.
 
Material and Methods: An observational, descriptive, cross-sectional study of 55 spermograms from patients with infertility problems from the “Instituto Quiteño de Infertilidad” was carried out.
Results: 47.27% of the spermogram presented normozoospermia. Within the alterations, asthenozoospermia was 25.45% and teratozoospermia was 23.63%. The values ​​of the sperm quality parameters and the number of alterations showed an age-related trend; we found that the highest number of affected patients with alterations in the number of sperm corresponds to those over 40 years.
Discussion: In our study, we have evidenced a high percentage of patients with at least one seminal alteration, especially in older patients, which indicates the importance of considering the age of males when evaluating infertile couples.