bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospects of infusion therapy in the treatment of severe pulmonary tuberculosis in combination with COVID-19
Authors: Todoriko L.D. , Gumeniuk M.I. , Semianiv I.O. , Sprynsian T.A. , Denysov O.S.
Published: October 2020

Background. Clinical experience has shown that in conditions of severe quarantine, patients with small respiratory syndromes do not have access to early and quality differential diagnosis. It increases the risk of hospitalization, in such cases, to the infectious department. In most cases, tuberculosis (TB) treatment is no different in people with coronavirus disease (COVID-19).

Objective. Analyze the outlook for the effects of the interaction between COVID-19 and TB, which remains the leading cause of death from a single infectious disease in the world, and for the reduce the risk of TB infection in a pandemic without losing treatment.

Results and discussion. Recently, patients with TB and COVID-19 syntropy, which requires off-label therapy, have to be treated more and more often. This is especially true for patients with diabetes who are at risk for both TB and coronavirus infection. In such cases, which account for approximately 10-15 % of the total, oral therapy (per os) has a high risk of being ineffective. Timely infusion therapy for the synthesis of infectious diseases – TB and COVID-19 – reduces the risk of lethal prognosis. The method of intravenous infusions of anti-TB drugs is the ability to quickly create very high concentrations of drugs in the pulmonary artery, bypassing the liver as the main organ of inactivation and presystemic metabolism. Experience with co-treatment of COVID-19 and TB remains limited. However, suspension of TB treatment in patients with COVID-19 should be exceptional. Prophylactic treatment of TB, treatment of drug-sensitive or resistant TB should be continued continuously to protect the patient’s health, reduce transmission of infection and prevent the development of drug resistance. Therapeutic trials and accumulation of practical experience are underway. However, there are currently no warnings regarding the interaction of drugs used in the treatment of COVID-19 and anti-TB drugs, including the use of infusion therapy in severe conditions.

Conclusions. Timely infusion therapy for the synthesis of infectious diseases – TB and COVID-19 – reduces the risk of lethal prognosis.
Investigation of sorption capacity of dye-affinity sorbents in the process of purification of factor VIII coagulation
Authors: Shurko N.O. , Danysh T.V.
Published: October 2020

Background. Chromatographic methods, in particular affinity chromatography, are the most effective in obtaining highly purified preparations of plasma proteins. The active triazine and vinyl sulfone dyes are the special group of ligands for affinity chromatograph. We found that the dye-affinity sorbents bind non-target to factor VIII (FVIII) proteins in the previous stages of the study. The sorption capacity of the affinity sorbent is defined as the maximum amount of sample (protein) that can bind to the column under certain conditions. Determining the adsorption limit or limiting capacity of the sorbent makes it possible to identify the feasibility of its use to extract a certain type of protein.

Objective. To study the sorption capacity of various dye-ligand affinity sorbents in the process of purification of FVIII.

Materials and methods. We used next sorbents: Diasorb-Procion Blue HB, Diasorb-Procion Gelb M4R and Diasorb-Procion Blue MXR. The cryoprecipitate was initial material. The total protein concentration was determined by the Bradford method, the activity of factors VIII – one-stage clotting method.

Results and discussion. Sorption of non-target proteins and FVIII activity were investigated after preparation of a number of dilutions of the initial solution of cryoprecipitate. Different concentrations of protein were applied per 1 cm3 of sorbent to select the optimal concentration and do not to oversaturate the column: I – 19.74±0.20 mg of protein/ml; II – 7.94±0.05 mg of protein/ml; III – 3.97±0.05 mg of protein/ml; IV – 1.96±0.04 mg of protein/ml. The maximum sorption capacity among the studied sorbents was 14.62±0.04 mg of protein / 1 cm3 for of sorbent Diasorb-Procion Blue HB. It was found that to achieve maximum purification of FVIII (highest specific activity), the optimal concentration of protein to 1 ml of sorbent should be in the range of 4-8 mg of protein / 1 cm3 of sorbent. The highest degree of purification for these sorbents was 19.65 times at an initial protein concentration of about 4 mg protein/ml (p≤0.01).

Conclusions. The sorption capacity of sorbents was calculated. It was demonstrated that the maximum sorption capacity is approximately 15 (14.62±0.04) mg of protein / 1 cm3 of sorbent.
IMPROVEMENT OF CROSS SECTION OF COMPRESSED ELEMENTS BY TOPOLOGICAL RATIONALIZATION
Authors: Shmukler V. , Lugchenko O. , Nazhem A.
Published: October 2020

The article describes the procedure of direct (rational) design of vertical compressed elements (columns, pylons, stiffening diaphragms, retaining walls). This technology is an exclusive modification of topological (bionic) rationalization. It is based on new energy principles and algorithms for sequential construction of geometric and / or physical-mechanical "image" of the structure. The example of the formation of energy-equivalent columns shows the sequence of computational operations of the method. The solution is built analytically in order to show the nuances of the necessary operations. At the same time, these examples show that the introduced optimization criteria in the form of en → const and U → inf U (here en is the value of the normalized density of potential deformation energy, and U is the potential energy of deformation) determine, including the minimum volume of constructs, as well as their minimum deflections. A fundamental element of the approach is the use of a new criterion of the limit state, which provides an estimate of the intensity of the element. In this case, the properties of the material and the type of stress-strain state are taken into account. The obtained analytical solution was used as a control test for the general computational procedure of the method. In this regard, the article presents the results of the analytical and numerical solution. The efficiency of the computational procedure is confirmed by the speed of its convergence and the minimum difference of geometric parameters (topology) of the structure with test examples. The technological sequence of computational operations of the method is completed by the construction of elements (pylons) with a simple external and complex internal geometry.

Keywords: deformation, energy, iteration, voids, cavity, rationalization.
Interactive Letter and Number Learning Machines For Early Childhood
Authors: Wicaksono Mochamad Fajar , Rahmatya Myrna Dwi , Rinaldi Angga
Published: October 2020

The purpose of this study is to design and create interactive learning machines for letters and numbers for early childhood. The machine designed is an interactive learning machine so that early childhood is interested in learning and can learn independently. Arduino Mega2560 is used as the main processor on this machine. On this machine, there are three modes, namely learning mode, question mode, and counting mode. In learning mode, Arduino will read every button input pressed, display on the LCD and make a sound through DF Player in accordance with the input received. In the question mode, Arduino will issue a question in the form of sound and wait for an answer via the input button found on the device. In arithmetic mode, Arduino will read the input of 10 LDR sensors covered by ice-cream sticks placed by young children and make sounds related to the amount. Questions on tools can be changed by using an android application designed in this study. Based on the test results, this tool has been running well where all modes can be run 100% whether it is learning mode, question mode, and counting mode.

Keyword— Arduino, Early childhood, LCD, DF Player, Letters, and Numbers, Counting
Meeting Room Reservation Mobile Base System for PT. Visionet Data Internasional
Authors: Setiadi Ade , Alfiah Fifit , Septiawan Fajar
Published: October 2020

Reservation Meeting Room System is a system that is used to reserve meeting rooms in real time in all offices of PT. Visionet Data Internasional, so that this system is easy for employees to use, there is no duplication of reservations for meeting rooms between employees, and can be used through employees' mobile devices. PT Visionet Data Internasional is a company engaged in the field of IT Consultants consisting of many departments that focus on the development and maintenance of software and hardware, with many departments using meeting rooms very intensely, obtained information systems used to book meeting rooms are inaccurate, not real time, complicated, and frequent duplication of orders. Therefore the system that will be created by the author is a renovation and update of the previous system that already exists at PT. Visionet Data Internasional. It is expected that with this system, it can minimize errors that occur in the previous system. This system is also expected to make it easier for all employees to book a meeting room at PT Visionet Data Internasional.
Gelir Düzeyi ve Sağlık Hizmet Talebi İlişkisi: Mikro Veriler ile Türkiye Örneği
Authors: DOĞAN Esra
Published: October 2020

Bu çalışmanın amacı Türkiye’deki sağlık hizmet talebi üzerinde, gelir düzeyinin doğrudan ve sağlık hizmeti talebinde geçen sürenin yol açacağı gelir kaybı dolayısıyla da zaman maliyeti nedeniyle gelirin dolaylı etkisini ortaya koyabilmektir. Bu amaç doğrultusunda teorik olarak ilgili literatür ve olgusal olarak da Türkiye’deki sağlık hizmetlerinden yararlananların yararlanma sürecine ilişkin tecrübeleri incelenmiştir. Teorik inceleme sağlık hizmet talebine yönelik modellerin ve bu modellerden hareketle geliştirilen sağlık ekonomisi literatürünün karşılaştırması; olgusal inceleme ise Türkiye İstatistik Kurumu Türkiye Sağlık Araştırması (2016) verilerinin analizi ve değerlendirilmesi ile gerçekleştirilmiştir. Yapılan incelemeler ile de Türkiye’de sağlık hizmeti talebinde gelirin doğrudan etkisi bulunduğu gibi, ortaya çıkan zaman maliyeti dolayısıyla dolaylı etkisi de bulunmaktadır. Sonuç olarak bu çalışmanın bulgularından hareketle, Türkiye’de uygulanan sağlık düzenlemelerinde gelir grupları arasındaki farklılıkların göz önünde bulundurulması gerekliliğinin önemi vurgulanmaya çalışılmıştır.
Türk Mimarisinde Çapraz “X” Motif ve İkonografisi
Authors: ÇAKMAKOĞLU KURU Alev
Published: October 2020

Kaynağı Orta Asya’da bulunan Türk Sanatının yeryüzünün farklı coğrafyalarında varlık gösteren binlerce yıllık yolculuğundaki eserlerinde aynı ya da benzer motiflere farklı dönem üslupları içerisinde yer verildiği görülmektedir. Taşınabilir nitelikte olanlarda, mimarlık eserlerinde karşımıza çıkan bu motifler kaya resimlerinden mezar taşlarına, keçelerden, halı ve kilimlere, maden ve ahşap eserlerden kümbet, türbe ve camilere daha nicelerine yansıyan Türk izleridir. Bu motifler kimi zaman üzerindeki esere bir aidiyet damgasını, mührünü vururken kimi zaman taşıdığı anlamla bir seslenişi, bazen da her ikisini beraberinde barındırırlar. Bazı motifler pek çok kültürde yer bulmuş olsa da hatta evrensel bir dili olsa da her milletin aynı motife kattığı anlam, süsleme programları içerisinde yer veriş şekli farklılık gösterebilmektedir. Zamanın süzgecinden geçen böyle motifler duyulardaki bellekteki izleri ile yaşamaya devam ederler. İşte bu makalede böyle motiflerden birinin, birbirini verev kesen iki çizginin oluşturduğu çarpraz olarak nitelenen “X” şeklindeki motifin Türk eserlerinde özellikle mimarideki yer alışı ve ikonografisinin üzerinde durulmaktadır.
Amartya Sen’in Düşüncesinde ‘Zenginliği Yönetme’ Problemi
Authors: ÇAMLI Ahmet Yavuz
Published: October 2020

Küresel ekonomiye ilişkin temel göstergelere bakıldığında yıllar itibariyle toplumların giderek daha fazla zenginleştiği görülür. Çeşitli raporlara göre de önümüzdeki yıllarda küresel milli gelirin çok daha fazla artacağı belirtilir. Öte yandan zenginleşen Batı toplumlarının bu süreci iyi yönetemediğine dair eleştiriler gün geçtikçe artmaktadır. Bu çerçevede çalışmanın amacı Nobel ödüllü iktisatçı Amartya Sen’in düşüncelerine başvurularak zenginleşme sürecinin doğru bir şekilde yönetilebilmesi için ne yapılması gerektiğinin vurgulanmasıdır. Bu doğrultuda Sen’in kapitalizmin sert çekirdeği olan rasyonel insan modeli eleştirisi kapsamında refah iktisadı, faydacı anlayış, yoksulluk ve kalkınma gibi iktisadi konuları etik temelli ele alış tarzı işlenmiştir. Ardından iktisadi literatüre kazandırdığı kapasite yaklaşımı ve özgürlükler gibi kavramlar ortaya koyulmuştur. Sen’in faydacı kuram ya da kapitalizm eleştirisi, yeni bir sistem üretme çabasından ziyade mevcut sistemin hatalarını giderme ve boşluklarını doldurma girişimidir. Yine de onun düşüncesinde insanın özne konumunun korunup sosyo-ekonomik politikaların merkezine yerleştirilmesi ve toplumsal barış, dayanışma ve işbirliğini destekleyen bir etik anlayışının ekonomi alanına kodlanması gibi özellikler sosyo-ekonomik gelişmenin sürdürülebilmesine zemin ve imkân hazırlaması açısından son derece önemlidir.
Dijital Bankacılıkta Müşteri Memnuniyetinin Çok Kriterli Karar Verme Yöntemleri ile Değerlendirilmesi
Authors: NOYAN Elçin , GAVCAR Erdoğan
Published: October 2020

Bilgi paylaşımının, akıllı telefonların kullanımı ile arttığı, dijitalleşme sürecinin hızlandığı günümüzde bankalar, müşterilerinin ihtiyaçlarını hızlı bir şekilde karşılamak için adeta yarış haline girmişlerdir. İçinde bulunduğumuz Koronavirüs (Covid 19) Salgını ile Dijital Bankacılığa yönelim artmış, Dijital Bankacılık gerek sağlık tedbirleri, gerekse bankaların işlem maliyetlerinin düşürülmesi, işlemler için belge, doküman gerektirmemesi yönleriyle, bankacılık hizmet kalitesinin artırılması ve müşteri memnuniyetinin sağlanması açısından önemli hale gelmiştir. Bu bağlamda literatürde Dijital Bankacılık ile ilgili çalışmalar genellikle sadece internet bankacılığı ürünüyle sınırlı kalmıştır. Çalışmanın amacı Dijital Bankacılık ürünlerini kullanımında müşterilerin memnuniyetlerine etki eden faktörlerin belirlenmesidir. Çalışmada, Muğla ili ve çevresine yüz yüze anket yoluyla elde edilen 170 adet veri Çok Kriterli Karar Verme (ÇKKV) Yöntemleri'nden Analitik Hiyerarşi Prosesi Yöntemi (AHP) temelli Multi-Objective Optimization on Basis of Ratio Analysis (MOORA) ve Elimination and Choice Translating Reality (ELECTRE)Yöntemleri kullanılarak analizler yapılmıştır. Analizler, Microsoft Excel programı ile gerçekleştirilmiş, birbirleri ile kıyaslanmıştır.
Çalışma sonucunda müşteri memnuniyetine en çok etki eden kriterin 'güven' olduğu görülmüştür. Dolayısıyla bankalar müşterilerini Dijital Bankacılık kanallarına yönlendirirken bu kanalların güvenli olduklarını vurgulamalı, kurum olarak ta bankalar müşterilerine güven vermelidirler. Elde edilen sonuçlar literatüre de paralellik göstermiştir. Dijital Bankacılık ürünlerinin kullanımının önündeki engellerin aşılması konusunda çalışmalar artırılmalı, toplumun dijitalleşmeye karşı güvensizlik algısı giderilmelidir.
S.M.M.M’lerin Finansal Okuryazarlık ve Finansal Tablo Okuryazarlık Düzeyinin Belirlenmesine Yönelik Bir Araştırma: Tunceli ve Elazığ Örneği
Authors: YALÇIN Zülkif , SANDAL Aysun
Published: October 2020

Günümüz gelişen ekonomisine adapte olmak adına fikir kirliliğiyle yanlış bilgi sahibi olmamak için finansal ve mali tablolar hakkındaki terimleri bilip, bu terimlerin finansal piyasaya etkilerini çözümleyip, işletmelere ayna tutmak bir zorunluluk haline gelmiştir. Bunun yanında finansal farkındalığın oluşması işletmelerin özenli ve gerekli finansal donanıma sahip olan, mali tabloları okuma kabiliyeti gelişmiş, muhasebe ile ilgili işlemlerini yürüten Serbest Muhasebeci Mali Müşavirler (S.M.M.M.) açısından duyarlılığın yüksek olmasıyla ilişkilidir. Bu bağlamda Serbest Muhasebeci Mali Müşavirlerin ekonomi açısından dağarcıklarında yer alan kuramların gerçeklikleriyle yüzleşmeleri hem kendilerini geliştirmeleri için hem de verdikleri hizmeti doğru bir şekilde aktarmaları için önemlidir. Bu bağlamda bu çalışmanın amacı; Tunceli ili ve Elazığ ilinde bulunan Serbest Muhasebeci ve Mali Müşavirlerin finansal ve mali tablo okuryazarlık düzeylerini ölçmeye çalışmaktır. Bu çalışmayı yaparken özellikle finansal ve mali tablo okuryazarlık hakkında yapılan çalışmalardan literatür taraması yapılacaktır. Daha sonra Tunceli ve Elazığ illerindeki Serbest Muhasebeci ve Mali Müşavirlerine önceden belirlenmiş demografik ve finansal bilgileri içeren anket uygulaması yapılacaktır. Çalışmamızda çoktan seçmeli anket uygulanmış olup anketler S.P.S.S. paket programında analiz edilmiştir. Araştırmamızın kısıtını bu illerde bulunan meslek mensuplarının anket sorularımıza yüz yüze görüşmemize rağmen cevap vermekten kaçınmalarıdır. Bu çalışma ile bu konuda yapılan bilimsel çalışmalara katkı sunmak temel amacımız olmuştur.
Engelli ve Engelli Olmayan Yüzücülerin Kendini Sabotaj ve Benlik Saygısı Düzeyleri
Authors: KAMUK Yetkin Utku , TÜZÜN Sevcan , DOĞAN Semra
Published: October 2020

Bu çalışmanın amacı, engelli ve engelli olmayan yüzücülerin kendini sabotaj ve benlik saygısı düzeylerinin incelenmesidir. Araştırmanın evrenini 2019 yılı Bedensel Engelliler Türkiye Şampiyonası’na katılan yüzücüler ile kulüplerde yarışan lisanslı yüzücüler, araştırma grubunu ise 64 engelli ve 138 engelli olmayan yüzücü (n=202) oluşturmaktadır. Gerekli etik kurul izni ve katılımcıların yazılı onamları çalışma öncesinde alınmıştır. Verilerin toplanması için kişisel bilgi formu, Rhodewalt’ın (1990) geliştirdiği ve Türkçe uyarlaması Akın (2012) tarafından yapılan “Kendini Sabotaj Ölçeği (KSÖ)” ile Rosenberg’in (1965) geliştirdiği ve Türkçe’ye Tukuş (2010) tarafından uyarlanmış olan “Benlik Saygısı Ölçeği (BSÖ)” kullanılmıştır. Veriler normal dağılım göstermediğinden, gruplar arasındaki farkların incelenmesi için Mann Whitney U ve Kruskal-Wallis H testleri kullanılmıştır. Korelasyon analizi için ise Spearman rho katsayısından faydalanılmıştır. İstatistiksel analizlerin sonuçlarına göre, engelli ve engelli olmayan yüzücülerin KSÖ ve BSÖ puanları arasında anlamlı bir fark olmadığı bulunmuştur. BSÖ ve KSÖ puanları arasındaki ilişki incelendiğinde, engelli yüzücülerin BSÖ puanları ile KSÖ puanları arasında orta düzeyde negatif yönlü bir ilişki olduğu, engelli olmayan yüzücülerde ise bu ilişkinin zayıf düzeyde olduğu bulunmuştur. Engelli sporcuların BSÖ puanlarının yüksek olduğu ve spor yapmanın engelli yüzücülerin KSÖ puanlarını olumlu etkilediği sonucuna ulaşılmıştır. Engelli bireylerin benlik saygısı düzeylerinin yükseltilmesini sağlamak amacıyla spor yapmaya teşvik edilmelerinin ve desteklenmelerinin faydalı olacağı değerlendirilmektedir.
COVID-19 Pandemisinin İnsan Kaynakları Üzerindeki Etkisinin Akademi, Medya ve İş Dünyası Perspektifinden İncelenmesi
Authors: KIRPIK Gülşen
Published: October 2020

COVID-19 Pandemisi sebebiyle, çalışma koşullarının nasıl değiştiği veya gelecekte nasıl değişeceği konusu ulusal ya da uluslararası düzeyde bilimsel araştırmalar, televizyon programları, gazete haberleri, online toplantılar ve benzeri çalışmalar ile güncel olarak üzerinde tartışılan önemli konular arasındadır. Bu çalışmanın amacı, küresel anlamda yaşanan COVID-19 pandemisinin insan kaynakları üzerindeki etkisinin ne olduğunun ya da gelecekte nasıl etkileyebileceğinin ortaya konmasıdır. Bu bağlamda, akademi, medya ve iş dünyasındaki online görüşler ve yayınlar üzerinden nitel bir inceleme yapılmıştır. Literatür taraması sırasında araştırmaya dahil edilme ve hariç tutulma kriterleri uygulanmıştır. Ulaşılan akademik çalışmalar ile haber, görüş ve önerilerden yararlanılarak insan kaynağının nasıl etkilendiği ya da etkilenebileceği tümevarımsal olarak değerlendirilmiştir. COVID-19 pandemisiyle birlikte, “evden çalışma”, “ücretli / ücretsiz izinlerin kullanılması”, “işsizliğin ortaya çıkışı”, “dijital çalışan, açık yaka çalışan ya da gri yakalı çalışanların öneminin artması”, “işletmelerin iflası”, “göçmen işçilerin sorunları” ve diğer bulgulara ulaşılmıştır. Bu bağlamda, yöneticilere, çalışanlara, araştırmacılara ve diğer ilgililere öneriler sunulmuştur.
Frequency of Birth Defects in a Tertiary Care Hospital in Bangladesh
Authors: Amin Tahsinul , Pervez Mehdi , Nur Ayesha Najma
Published: October 2020

Background: Birth defects usually present at birth and may cause morbidity and mortality in the newborn. These defects may involve any organ system of the body. Gradually the incidence is rising due to various etiologies. The objective of the study was to find out the frequency, types and etiology of birth defects.

Materials & Methods: This cross-sectional study was done in a tertiary care hospital in Bangladesh. In this study, 100 neonates with birth defects were enrolled, thoroughly examined, investigated and evaluated. Then collected data were analyzed.

Results: The frequency of birth defects in this study was 1.54%. The most frequent birth defect was club foot deformity i.e. 11% and the most frequently involved organ system was cardiovascular system i.e. 28%. Among the birth defects 78% were major and only 22% were minor. Among those children with birth defect mortality was 17%; 41% were referred to advanced center and 42% were improved and discharged. In some of the cases with birth defect chromosomal anomaly, congenital infection (TORCH), maternal diabetes was found as causing factor.

Conclusion: The frequency of birth defects was found 1.54% and most of the birth defects were major defect. Club foot deformity was found as the most common birth defect.

Bangladesh J Child Health 2020; VOL 44 (1) :8-12
Cornelia de Lange Syndrome A Case Report
Authors: Karim Muhammad Rezaul , Begum Suraiya , Shamaly Kohinoor Jahan , Zannat Ismot Ara
Published: October 2020

Cornelia de Lange syndrome (CdLS) is a rare syndrome of multisystem disorder. Almost every system is involved in this disorder having growth retardation, facial dysmorphism, short stature, psychomotor delay and behavioral problems. Diagnosis is made on the basis of clinical observations, physical examination, laboratory tests and X-rays; chromosome analysis is usually conducted before a diagnosis is made. DNA testing is helpful for confirmation of the clinical diagnosis. A 10 year old boy presented with short stature, facial dysmorphism, microcephaly, mental retardation and micromelia. DNA analysis revealed heterozygous mutation in NIBPL gene. Patient was counseled about the diagnosis and treatment was given. We reported the case due to rarity of the disease.

Bangladesh J Child Health 2020; VOL 44 (1) :52-54
Persistent Pulmonary Hypertension of Newborn (PPHN)
Authors: Hussain Manzoor
Published: October 2020

Abstract not available

DS (Child) H J 2019; 35(2) : 90-93
Role of Macronutrient in Better Survival of Critically Sick Neonates Admitted in Neonatal Intensive Care Unit (NICU)
Authors: Mohammad Yusuf Mir , Chowdhury MAK Azad , Alam Md Jahangir
Published: October 2020

Background: Neonates are considered more susceptible to macronutrient deficits. During critical illness, sick children cannot normally be fed by mouth, and as a result a pronounced macronutrient deficit often develops after a few days. This macronutrient deficit has been associated with weakness, infections and increased risk of mortality. Therefore, macronutrient as energy source is an important key concern to care and for overall to achieve better survival.

Objective: The present study is intended to evaluate the role of macronutrient such as blood glucose, serum calcium, hemoglobin as iron status, serum albumin, in critically sick neonates admitted in NICU and their outcome.

Methods: This observational prospective study was carried out at NICU of Dhaka Shishu (Children) Hospital from January 2014 to July 2014. Total 121 neonates were enrolled and analyzed their essential macronutrient profile e.g, blood glucose, serum calcium, hemoglobin, serum albumin and other relevant investigation as complete blood count with film, CRP, blood culture and chest X ray as a part of management as well as to predict their survival.

Results: Macronutrient of critically sick neonates play important role to predict their better survival. Perinatal asphyxia and sepsis were major diagnosed pathological conditions of these neonates. In sepsis lower value of serum albumin were statistically significant. Lower value of glucose, calcium, hemoglobin and albumin were also statistically significant in Non-survivors than Survivors.

Conclusion: During critical illness in neonates, emphasis should be paid on of adequate macronutrient as energy source. This is necessary for better optimization survival of critically sick neonates.

DS (Child) H J 2019; 35(2) : 105-110
Effectiveness of a Multidisciplinary Lifestyle Intervention to Reduce Obesity among Children and Adolescents
Authors: Ahsan Md Rizwanul , Makbul Sabrina , Sarkar Probir Kumar
Published: October 2020

Background: Now a days unhealthy lifestyle primarily responsible for the dramatic increase obesity among children and adolescents.

Objective: The purpose of the study is to see the effects of a multidisciplinary lifestyle intervention to reduce obese children and adolescents. The main outcome was cardiometabolic risk based on the waist-to-height ratio (WHTR) measurement. Secondary outcomes were (1) changes in body composition; (2) adherence to a Mediterranean diet; and (3) physical performance.

Methods: The study involved 64 overweight/obese children or adolescents conducted at Dhaka Shishu Hospital from October 2017 to September 2018. The intervention was multidisciplinary including nutrition, exercise, and psychological aspects based on a family-based approach; it was delivered for six months for children and three months for adolescents. Before and after the intervention, several anthropometric measures height, body weight, body mass index (BMI), waist circumference, and body composition, cardiometabolic risk index waist-to-height ratio (WHTR), and dietary habits of the participants and their families were evaluated. In addition, a set of functional motor fitness tests was performed to evaluate physical performance measures.

Results: After the intervention both children and adolescents showed a significant reduction in body weight, BMI, waist circumference, fat mass, and WHTR index and an improvement of fat-free mass, adherence to the Mediterranean diet, and physical fitness performance.

Conclusion: A short term family-based multidisciplinary approach is effective in ameliorating the health status, dietary habits, and physical performance in children and adolescents.

DS (Child) H J 2019; 35(2) : 111-118
Congenital Harlequin Ichthyosis: A Rare genetic Disorder
Authors: Parveen Umme , Sultana Kiswar , Alam Mia Mamtaz Daulat
Published: October 2020

Abstract not available

DS (Child) H J 2019; 35(2) : 179-181
Mitä koulutussuunnittelussa tapahtuu?
Authors: Numminen Jaakko
Published: October 2020

Artikkeli on katsaus maassamme harjoitettuun koulutussuunnitteluun. Siinä tarkastellaan koulutusjärjestelmän kaikkia osa-alueita ja toteutettuja kehittämishankkeita viimeisten 15 vuoden aikana. Samalla selvitetään suunnittelun nykytilaa ja ennakoidaan tulevia toimenpiteitä.
Koulutuksemme kehittämisen pääidea
Authors: Lehtisalo Liekki
Published: October 2020

Artikkelissa selostetaan opetusministeriön asettaman Jatkuvan koulutuksen toimikunnan mietinnön sisältöä ja ehdotuksia. Painopiste on jatkuvan koulutuksen periaatteen koko koulutusjärjestelmälle ja sen eri lohkoille asettamissa kehittämisvaatimuksissa. Aikuiskoulutus nousee tarkastelussa korostetusti esille.
The anti hypertensive nutraceuticals of Vigna sp bean protein hydrolized by alcalase and flavourzyme
Authors: Tejasari  , Yuwanti Sih , Ahmadi Mohammad Bazar , Afsari Yuna Luki
Published: October 2020

Peptide with hydrophobic amino acids had been studied for their inhibitory activity against angiotensin-I converting enzyme (ACE-1) transformation into ACE-2 and prevention of hypertension. The active peptides may come from alcalase and flavourzyme hydrolysis of bean protein. This study aimed to measure ACE-1 inhibitory of protein hydrolysates from Vigna sp. bean (mung bean and cowpea) that grew in Indonesia, and its solubility. The bean protein (22.9 - 23.6 %) was extracted using isoelectric precipitation at pH 4-4.6. The extracts were hydrolyzed at pH 8 for alcalase and pH 7 for flavourzyme, followed with inactivation at 80-85 oC. ACE-1 inhibitory activity was calculated based on the amount of hippuric acid (HA) formed by the hydrolysis of Hippuryl-His-Leu (HHL), in spectrophotometry detection method (228 nm). Ultrachromatography evaluation showed that the protein hydrolysates of mungbean contained higher hydrophobic amino acids (382 mg/g protein) compared to those of cowpea (329 mg/g protein). Protein hydrolysates of both beans from alcalase hydrolysis have higher ACE-1 inhibitory activity rather than those from flavourzyme. Protein hydrolysate from Vigna spp bean protein hydrolysis by alcalase, contained small molecular weight peptides (3.9-4.63 kDa) and high ACE-1 inhibition ability (80-93 %), and therefore suggested as antihypertensive nutraceuticals. Highest solubility of protein hydrolysates resulted from alcalase hydrolysis of both beans were observed at pH 8, while those resulted from flavorzyme hydrolysis were at pH 7, respectively.
Dominant Forms and Marginal Translations: Re-reading the Emergence of the Novel in Nineteenth-Century Japan
Authors: Garza James
Published: October 2020

Franco Moretti has defined form as ‘the repeatable element of literature’. However, without a precise definition of the form(s) analysed in a given study, it is difficult to gauge what has been repeated. Moreover, no matter what guise we consider ‘form’ to take, the following objection remains: just because some element has been (or seems to have been) repeated, this does not mean that its function has been repeated too. In terms of Japanese literary history, perhaps no period better demonstrates this than the Meiji period (1868–1912). The main innovation of this paper is to adapt the text-linguistic notions of acceptability and intertextuality (see de Beaugrande and Dressler) to show that this period's ‘familiar history of rupture’ (cf. Zwicker) is indeed a valid framework for understanding the emergence of modern Japanese prose fiction. In this appeal to local context, I locate an alternative to the temptation to see, as Moretti does, an increasing amount of ‘sameness’ on the global literary stage.
Spivak's Planetarity and the Limits of Professional Reading
Authors: Toth Hayley G.
Published: October 2020

This article argues that Gayatri Chakravorty Spivak's notion of planetarity is premised on a practice of reading. Reading for the planet involves deferring the world in order to participate in the text world and its latent re(-)production of ourselves and our world. To the extent that this ethical attention moves us toward different horizons of thinking and feeling, it may also engender political action in the public realm. Reading for Spivak is therefore an important foundation for revolutionary politics and, ultimately, the production of the planet to which we aspire as readers. I proceed to evaluate the planetary efficacy of Spivak's complementary teaching praxis. I show that the aesthetic education she provides does not enable but rather forecloses the experience of literariness and its associated ethics and politics. In response to the limits of professional reading and the worldliness of Spivak's fieldwork in India, I conclude by thinking about the value of deprofessionalization.
Cu, Cd, As and Hg resistance levels in Escherichia coli isolated from Mediterranean mussel and sea snail in the Southeastern Black Sea
Authors: TERZİ Ertuğrul , CİVELEK Fatih
Published: October 2020

Marine environment is exposed to various pollutants such as heavy metals, pesticides, and antibiotics. Bacterial resistance to these pollutants is a global problem all over the world. In this study, Mediterranean mussel (Mytilus galloprovincialis) and sea snail (Rapana venosa) were collected from 12 sampling points from Artvin, Rize, Trabzon, and Giresun Coasts of Black Sea, Turkey. A total of 54 Escherichia coli isolated from Mediterranean mussel and sea snail were tested for their ability to tolerate Cu, Cd, As, and Hg. For this purpose, minimum inhibitory concentration (MIC) tests for all isolates to the Cu, Cd, As, and Hg were done to determine tolerance or resistance using the broth dilution technique. MIC concentration for Cu, Cd, As, and Hg ranged between 100-400 μg/ml, 100-200 μg/ml, 25-400 μg/ml, and 3.125-25 μg/ml, respectively. All of the strains were determined as resistant to Cu, but sensitive to As. Resistance to Hg was determined as 7.4 %. The most common resistance gene in the bacteria was nccA and followed by chrB and merA. Tolerance or resistance of the bacteria to toxic pollutants including heavy metal(oid)s is of significant ecological importance. These bacteria could be used for monitoring environmental heavy metal(oid) pollution.
Determination of Spatial and Temporal Changes in Surface Water Quality of Filyos River (Turkey) Using Principal Component Analysis and Cluster Analysis
Authors: YAĞANOĞLU Elif , YAĞANOĞLU Aycan Mutlu , ARSLAN Gokhan , SÖNMEZ Adem Yavuz
Published: October 2020

Monitoring water quality is one of the high priorities for the protection of water resources. Many different approaches are used to analyse and interpret the variables that determine the variance of water quality observed in various sources. Statistical methods, especially multivariate statistical techniques, constitute an important part of these approaches. In this study, ten water quality parameters, which were measured for twelve months from seven stations determined on Filyos River, were evaluated by carrying out principal component analysis (PCA) and cluster analysis (CA) from multivariate statistical methods. In addition, dominant quality parameters designating the quality of the water source were determined. According to PCA results, 4 principal components contained the key variables and accounted for 69.49% of total variance of surface water quality from Filyos River. Dominant water quality parameters were observed to be temperature, EC, DO and pH. While the study revealed that the river is exposed to agricultural pollution alongside with the water quality character generated by the climatic conditions, it also suggested that multivariate statistical methods are useful tools in evaluating complex data sets such as water quality data, and monitoring the quality of water resources.
IMPROVING MODIFIED ICOLD METHOD WITH LOSS OF LIFE INDEX FOR DAM SAFETY RISK ASSESSMENT
Authors: Henrianto A. , Triweko R.W. , Yudianto D.
Published: October 2020

This research paper explains the results of the prediction analysis of the number of lives lost in the event of a catastrophic dam collapse in Indonesia as a further consideration in assessing the level of risk of dam safety. The proposed procedure is to make a new prediction index of the number of lives lost (LoL) as the development of a risk index of evacuation requirements from Risk Affected Populations (PENRIS), on the Modified ICOLD Method which is always used in Indonesia. This study, resulting in a regression equation as a correlation between PENRIS and LoL, takes its source from various catastrophic dam collapse events that have occurred in the world including Indonesia. Furthermore the regression equation is integrated with the standard determination of the level of risk of dam safety used in Indonesia and the world, for conditions with and without a disaster early warning system based on the Graham formula (2010). Further analysis of the Emergency Action Plan (EAP or RTD) of 16 dams in Indonesia as a sample, gives an indication that the implementation of an early warning system will reduce the amount of LoL by almost 100% if implemented according to design. This research, with its focus on developing a prediction index for the number of LoL, proves that in Indonesia, where there are still many dams eventhough they already have RTDs, and have not conducted a disaster-based space arrangement based on predicted LoL numbers,the reduction in the value of dam security risks can only be optimal in the range of 50 % of the total dam studied.
Primer reporte de Fusarium oxysporum f. sp. lycopersici raza 1 aislada de tomate (Solanum lycopersicum L.) proveniente de la Costa central del Perú
Authors: Huarhua Medali , Aragón Liliana , Flores Juan , Tsuzuki Rin , Arie Tsutomu
Published: October 2020

Antecedentes: Fusarium oxysporum f. sp. lycopersici (Fol) causa la marchitez vascular en tomate. Las especies de Fusarium pueden llegar a ser identificadas por características morfológicas. Sin embargo, para poder detectar las formas especiales, razas o formas patogénicas se emplean herramientas moleculares o cultivares diferenciales. Actualmente, en el Perú no existe reporte de la identificación de razas de Fol.

Objetivos: Identificar mediante técnicas moleculares y empleo de cultivares diferenciales, razas de Fusarium oxysporum asociados a la marchitez de tomate provenientes de la costa del Perú.

Métodos: Identificación morfológica de ocho aislamientos de Fusarium de tomate, seguido de los análisis filogenéticos basados en las regiones espaciadoras intergénicas del ADN ribosomal (IGS). Además, se realizó la detección de los genes (SIX4, SIX3 y SIX1) y fragmentos de los genes endo (pg1) y exo (pgx4) poligalacturonasa. La prueba de patogenicidad fue realizada en cultivares diferenciales de tomates (Ponderosa, Momotaro, Momotaro 8 y Block).

Resultados y conclusiones: De acuerdo a los análisis moleculares y prueba de patogenicidad, se identificó al aislamiento HEI 11 como Fol raza 1.
Assessing the Influence of Soil Quality on Rainfed Wheat Yield
Authors: Nabiollahi Kamal , Heshmat Eskandari , Mosavi Amir , Kerry Ruth , Zeraatpisheh Mojtaba , Taghizadeh-Mehrjardi Ruhollah
Published: October 2020

Soil quality assessment based on crop yields and identification of key indicators of it can be used for better management of agricultural production. In the current research, the weighted additive soil quality index (SQIw), factor analysis (FA), and multiple linear regression (MLR) are used to assess the soil quality of rainfed winter wheat fields with two soil orders on 53.20 km2 of agricultural land in western Iran. A total of 18 soil quality indicators were determined for 100 soil samples (0–20 cm depth) from two soil orders (Inceptisols and Entisols). The soil properties measured were: pH, soil texture, organic carbon (OC), cation exchange capacity (CEC), electrical conductivity (EC), soil microbial respiration (SMR), carbonate calcium equivalent (CCE), soil porosity (SP), bulk density (BD), exchangeable sodium percentage (ESP), mean weight diameter (MWD), available potassium (AK), total nitrogen (TN), available phosphorus (AP), available Fe (AFe), available Zn (AZn), available Mn (AMn), and available Cu (ACu). Wheat grain yield for all of the 100 sampling sites was also gathered. The SQIw was calculated using two weighting methods (FA and MLR) and maps were created using a digital soil mapping framework. The soil indicators determined for the minimum data set (MDS) were AK, clay, CEC, AP, SMR, and sand. The correlation between the MLR weighting technique (SQIw-M) and the rainfed wheat yield (r = 0.62) was slightly larger than that the correlation of yield with the FA weighted technique (SQIw-F) (r = 0.58). Results showed that the means of both SQIw-M and SQIw-F and rainfed wheat yield for Inceptisols were higher than for Entisols, although these differences were not statistically significant. Both SQIw-M and SQIw-F showed that areas with Entisols had lower proportions of good soil quality grades (Grades I and II), and higher proportions of poor soil quality grades (Grades IV and V) compared to Inceptisols. Based on these results, soil type must be considered for soil quality assessment in future studies to maintain and enhance soil quality and sustainable production. The overall soil quality of the study region was of poor and moderate grades. To improve soil quality, it is therefore recommended that effective practices such as the implementation of scientifically integrated nutrient management involving the combined use of organic and inorganic fertilizers in rainfed wheat fields should be promoted.
Comprehensive In Silico Characterization and Expression Profiling of Nine Gene Families Associated with Calcium Transport in Soybean
Authors: Zeng Houqing , Zhao Bingqian , Wu Haicheng , Zhu Yiyong , Chen Huatao
Published: October 2020

Calcium (Ca2+) plays a critical role in the regulation of growth and development and environmental stress responses in plants. The membrane-associated Ca2+ transport proteins are required to mediate Ca2+ signaling and maintain Ca2+ homeostasis. Ca2+ channels, pumps (ATPases), and antiporters are three major classes of Ca2+ transporters. Although the genome-wide analysis of Ca2+ transporters in model plants Arabidopsis and rice have been well documented, the identification, classification, phylogenesis, expression profiles, and physiological functions of Ca2+ transport proteins in soybean are largely unknown. In this study, a comprehensive in silico analysis of gene families associated with Ca2+ transport was conducted, and a total of 207 putative Ca2+ transporter genes have been identified in soybean. These genes belong to nine different families, such as Ca2+-ATPase, Ca2+/cation antiporter, cyclic nucleotide-gated ion channel (CNGC), and hyperosmolality induced cytosolic Ca2+ concentration channel (OSCA). Detailed analysis of these identified genes was performed, including their classification, phylogenesis, protein domains, chromosomal distribution, and gene duplication. Expression profiling of these genes was conducted in different tissues and developmental stages, as well as under stresses using publicly available RNA-seq data. Some genes were found to be predominantly expressed in specific tissues like flowers and nodules, and some genes were found to be expressed strongly during seed development. Seventy-four genes were found to be significantly and differentially expressed under abiotic and biotic stresses, such as salt, phosphorus deficiency, and fungal pathogen inoculation. In addition, hormonal signaling- and stress response-related cis-elements and potential microRNA target sites were analyzed. This study suggests the potential roles of soybean Ca2+ transporters in stress responses and growth regulation, and provides a basis for further functional characterization of putative Ca2+ transporters in soybean.
Proposal of a Bioregional Strategic Framework for a Sustainable Food System in Sicily
Authors: Guarnaccia Paolo , Zingale Silvia , Scuderi Alessandro , Gori Ezio , Santiglia Vincenzo , Timpanaro Giuseppe
Published: October 2020

The alignment of food systems with the Sustainable Development Goals (SDGs) is generally envisaged to make a positive impact on sustainability. This paper outlines some critical environmental and socio-economic indicators for Sicily in order to compare and explore the outcomes of two juxtaposing key drivers in a scenario planning exercise, where the extremities are Industrial versus Regenerative Agriculture/Agroecology and a Proactive versus Reactive government response. The most rational and less risky scenario becomes the most sensible sustainable development option, around which a 2030 vision is projected for a bioregional sustainable food system for Sicily, which is aligned with the SDGs and related policies. To accomplish the 2030 vision, a holistic education-led developmental approach is outlined with a supporting bioregional strategic framework, whose key milestone deliverables are projected through a backcasting process. This paper therefore highlights the importance of consistency and alignment of a development vision with its strategic framework and ensuing implementation, failing which, the holistic bioregional approach is compromised by activities that are shown to negatively impact environmental and socio-economic indicators. For this reason, all public and private sector development plans and associated resources ought to be aligned with a bioregional strategic plan for a sustainable food system for Sicily.
Beyond Beer: Hop Shoot Production and Nutritional Composition under Mediterranean Climatic Conditions
Authors: Rossini Francesco , Virga Giuseppe , Loreti Paolo , Provenzano Maria Elena , Danieli Pier Paolo , Ruggeri Roberto
Published: October 2020

For hop growers, surplus shoots are generally a useless by-product of cultivation. Conversely, they may represent a valuable resource due to rising interest towards healthy and traditional foods. A field trial was carried out in Central Italy to characterize shoot production (number of emerged shoots, shoot fresh weight, marketable shoot yield, and shoot diameter) of three commercial hop cultivars (Cascade, Challenger, and Hallertauer Magnum) and to survey shoot proximate composition (ash, ether extract, crude protein, and crude fiber). Green shoots were harvested when they were from 20 to 40 cm in length. The results from two years showed that there was significant difference among the varieties and between growing seasons, both for yield traits and for nutritional composition. H. Magnum showed the highest marketable shoot yield (152 g per plant, two-year mean), while Cascade had the best proximate composition. The number of emerged shoots per plant varied from 62.5 of Cascade to 84.3 of H. Magnum over a two-year average. Marketable shoot yield showed a positive relationship with number of shoots and average shoot fresh weight, while no significant correlation was found with shoot diameter. Hop shoots proved to be a low-fat food (ether extract from 2 to 6% dry matter (DM)) with high protein (from 22 to 30% DM) and fiber content (from 10 to 16% DM).
Regulation of Nrf2/ARE Pathway by Dietary Flavonoids: A Friend or Foe for Cancer Management?
Authors: L. Suraweera Tharindu , Rupasinghe H. P. Vasantha , Dellaire Graham , Xu Zhaolin
Published: October 2020

The nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an important cell signaling mechanism in maintaining redox homeostasis in humans. The role of dietary flavonoids in activating Nrf2/ARE in relation to cancer chemoprevention or cancer promotion is not well established. Here we summarize the dual effects of flavonoids in cancer chemoprevention and cancer promotion with respect to the regulation of the Nrf2/ARE pathway, while underlying the possible cellular mechanisms. Luteolin, apigenin, quercetin, myricetin, rutin, naringenin, epicatechin, and genistein activate the Nrf2/ARE pathway in both normal and cancer cells. The hormetic effect of flavonoids has been observed due to their antioxidant or prooxidant activity, depending on the concentrations. Reported in vitro and in vivo investigations suggest that the activation of the Nrf2/ARE pathway by either endogenous or exogenous stimuli under normal physiological conditions contributes to redox homeostasis, which may provide a mechanism for cancer chemoprevention. However, some flavonoids, such as luteolin, apigenin, myricetin, quercetin, naringenin, epicatechin, genistein, and daidzein, at low concentrations (1.5 to 20 µM) facilitate cancer cell growth and proliferation in vitro. Paradoxically, some flavonoids, including luteolin, apigenin, and chrysin, inhibit the Nrf2/ARE pathway in vitro. Therefore, even though flavonoids play a major role in cancer chemoprevention, due to their possible inducement of cancer cell growth, the effects of dietary flavonoids on cancer pathophysiology in patients or appropriate experimental animal models should be investigated systematically.