bluuebunny/crossref_metadata_2025 huggingface dataset:
EL PERFIL DE INGRESO DE ESTUDIANTES AL CAMPUS SALINAS DE LA UASLP
Authors: Valdivia Altamirano William Fernando
Published: October 2021

OBJETIVO: Describir el perfil de los estudiantes aspirantes y la forma en que eligen la carrera, de los que presentaron el examen de admisión al Campus Salinas de la UASLP.

MATERIAL Y MÉTODO: El estudio es descriptivo, transversal, cuantitativo. La información se obtuvo a través de un cuestionario de 16 preguntas, a un total de 15 aspirantes de un total de 80, que fueron seleccionados aleatoriamente, el día del examen a las carreras del Campus Salinas de la UASLP, Salinas de Hidalgo, municipio de San Luis Potosí.

RESULTADOS: En los aspirantes hay paridad de género, son relativamente jóvenes (17 a 18 años), casi en su totalidad proceden del estado de San Luis Potosí y del municipio de Salinas. El proceso de selección de la carrera es complejo, la información sobre ellas debe ser de calidad, continua y juvenil.

CONCLUSIONES: La investigación ayudó a entender a los aspirantes a sus Licenciaturas y a comprender cómo eligen la carrera, información que es necesaria para atenderlos en lo relativo a la docencia, tutoría y desarrollo personal.
AUSENCIA DE UNA NORMATIVA CONTABLE Y FISCAL COMO BASES DE REVISIÓN EN MATERIA AMBIENTAL EN MÉXICO
Authors: Murrieta Martínez Natalia , Ricárdez Jiménez Jerónimo D. , Vega Zárate César
Published: October 2021

La aparición del término desarrollo sustentable ha generado una importante conciencia social sobre la relación existente entre la naturaleza y el ser humano cuya interacción ha sobrepasado el ámbito ecológico. Así, desde su apreciación en el Informe de Bruntland en 1987, la presencia de la disciplina económica, se muestra como una corriente imperante para lograr que ese proceso de concientización ecológica sea incorporado por las empresas para proteger al medio ambiente.
A partir de esto, conceptos como contabilidad ecológica y fiscalidad verde aparecen como instrumentos necesarios para que las empresas guíen sus acciones hacia un beneficio ecológico a la par de sus fines empresariales. Así, la incorporación de tales fenómenos ha requerido que sus estructuras normativas sean adaptadas para tal fin, buscándose maneras para contaminar menos y ayudar al planeta. Sin embargo, en México ambos conceptos no han evolucionado del mismo modo, limitándose a escasas regulaciones contables y fiscales que no han sido de gran peso para las empresas mexicanas en virtud de que aún lo ven como ajeno a su realidad empresarial.
Basándose en la comparación de la normativa de ambos conceptos con el Indicador Verde de la Bolsa Mexicana de Valores, se detecta que la intención de las empresas en cuidar al planeta va en aumento a pesar de la escasa regulación contable y fiscal. Por lo tanto, se sugiere que la auditoría ambiental formalice su procedimiento de revisión en materia financiera y no se limite al aspecto administrativo y operativo que actualmente se aplica en nuestro país.
EL MERCADO DE ENDULZANTES NATURALES EN MÉRIDA, YUCATÁN: EL CASO DEL PILONCILLO
Authors: Flores Novelo Anel , González Gutiérrez Magdalena
Published: October 2021

OBJETIVO: Analizar las características y condiciones del mercado de los endulzantes naturales, especialmente el piloncillo, en la ciudad de Mérida, Yucatán.

MATERIAL Y MÉTODO: Este trabajo presenta los resultados de una investigación cuantitativa con enfoque positivista, que tuvo como sujeto de estudio a los consumidores de endulzantes naturales ubicados en la ciudad de Mérida, Yucatán.

RESULTADOS: Los resultados muestran un consumo responsable, con consumidores que estan informados de lo que son endulzantes naturales, pues la mayor parte fue capaz de reconocerlos.
Asimismo, se encontró que al menos un 10% de los consumidores confunden la Stevia con el Splenda, que es un endulzante no natural.
Se encontró que los endulzantes naturales mas consumidos son miel, Stevia y piloncillo; aunque definitivamente la Miel es la que se menciona con mayor frecuencia, esta es considerada principalmente como segunda opción, siendo la principal la Stevia.

CONCLUSIONES: Existe un mercado para la comercialización del piloncillo. Siendo que ninguna marca esta posicionada, hay oportunidades para entrar como pionero en el mercado. El trabajo describe las preferencias y comportamiento de compra de los consumidores de endulzantes naturales, pero enfatizando la situación del piloncillo.
GENERACIÓN MILLENNIAL: CONSUMO GASTRONÓMICO Y TURÍSTICO
Authors: Quevedo Pérez Ilse Alexandra , Pérez Zurita Enriqueta
Published: October 2021

OBJETIVO: Conocer los gustos y preferencias de la Generación Millennial con respecto a sus requerimientos de consumo de alimentos y servicios turísticos.

MATERIAL Y MÉTODO: El enfoque de la investigación fue cualitativo, utilizando las técnicas de recolección en campo a través de un sondeo flash digital, donde se utilizó un instrumento de diseño propio. Asimismo, se desarrolló trabajo de gabinete con revisión documental. El informante clave fue un grupo de personas pertenecientes a la Generación Millennial.

RESULTADOS: Se encontró que los Millennials son una generación que se caracteriza por el uso de los dispositivos electrónicos para reservar anticipadamente sus viajes, que suelen ser frecuentes. En cuanto a sus gustos y frecuencia de consumo gastronómico, prefieren comida personalizada mayormente.

CONCLUSIONES: Los principales hallazgos de la investigación muestran una congruencia entre la teoría y las declaraciones de los informantes clave, respecto a los gustos y preferencias en la realización de actividades y requerimientos de servicios de gastronomía y turismo, por parte de la Generación Millennial.
EL CLIENTE COMO PROVEEDOR DE INNOVACIÓN. UN ENFOQUE DE CAPACIDADES DINÁMICAS EN PYME
Authors: Arellano Rodríguez Juan Bernardino , Sánchez Gutiérrez José , Mejía Trejo Juan
Published: October 2021

La inversión en capital del conocimiento, y en innovación se considera por varios autores como elemento clave para la mejora en productividad. Este documento propone la utilización del enfoque de capacidades dinámicas para administrar el conocimiento, para la generación de innovación, lo cual llevaría a las empresas a mejoras en productividad, y a escalar posiciones en la cadena de valor global.
PROMOCIÓN DE LA RESPONSABILIDAD SOCIAL EN EMPRESAS MANUFACTURERAS EXPORTADORAS DEL ESTADO DE HIDALGO PARA EL DESARROLLO REGIONAL
Authors: Muñoz Bautista Eduardo , Cerón Islas Arlén , Hernández Ortiz Iván , López García Sofía Emilia
Published: October 2021

El presente artículo, es parte del resultado de la investigación “La responsabilidad social empresarial en empresas exportadoras manufactureras del Estado de Hidalgo”.

OBJETIVO: Identificar la opinión de empleados hacia las acciones y requerimientos de responsabilidad social empresarial para realizar propuesta de modelo de RS.

MATERIAL Y MÉTODO: El diseño de la investigación es transversal y correlacional, considerando una muestra de 25 empresas activas de 38 en el ramo, mediante el muestreo probabilístico por áreas y polietápico ponderando, respectivamente en 4 municipios, el método de recolección de la información fue mediante una encuesta aplicada a 25 empleados de nivel directivo y 250 de nivel operativo.

RESULTADOS: Los directivos se identificaron en apoyos al conocimiento de la RS apenas si el 56% lo considera en referencia asesoría, mientras que el 64% considera apoyos en cuanto a capacitación y elementos tecnológicos.

CONCLUSIONES: De los requerimientos para la aplicación de la Responsabilidad Social, se consideran dos dimensiones: apoyos al conocimiento RS y apoyos requeridos de otros organismos. Este documento puntualiza la promoción para implementar la responsabilidad social en las empresas manufactureras exportadoras que contribuyan al desarrollo regional del Estado de Hidalgo de manera sustentable.
ESTRATEGIAS ECONÓMICAS DEL GRUPO FAMSA
Authors: Pérez Jiménez Oscar , Pérez Sánchez Beatriz
Published: October 2021

El estudio del comercio en la economía, conlleva a identificar las unidades económicas involucradas en la relación de producción y consumo, el comercio minorista o al detalle contribuye, a través de las tiendas departamentales a cumplir el rol de modernidad asignado por el mercado.
OBJETIVO: Analizar las estrategias competitivas, dimensiones y estructura que le permitieron al Grupo FAMSA constituirse en un gran corporativo y permanecer en el mercado.
MATERIAL Y MÉTODO: Los métodos empleados fueron: histórico, analítico y descriptivo. Se utilizaron fuentes secundarias: página web de la empresa e Informes y Reportes Anuales del Grupo FAMSA y de la Bolsa Mexicana de Valores.
RESULTADOS: El periodo de estudio 1970-2019, marca una evolución en la apertura de tiendas, infraestructura y organización corporativa que le permitiera distribuir y sostener la demanda de sus productos, en todo el territorio nacional e incluso en algunas ciudades de Estados Unidos, el aumento de su oferta a través de la diversificación y el crédito que llegó a constituir el 80% de sus ventas.
CONCLUSIONES: Las estrategias económicas realizadas para crecer implicaron: a) un crecimiento horizontal en el territorio nacional; b) fabricación de algunas de sus mercancías, marcas propias y exclusivas y diversificación de productos; c) expansión de su mercado a los Estados Unidos; d) búsqueda de financiamiento a través de alianzas y cotizar en la bolsa de valores; e implementación bancaria; adquisiciones y desinversiones.
SARAY VE SULTAN 1) SARAY
Authors: KÜÇÜK Sabahattin
Published: October 2021

Geleneksel öğretilerde, yeryüzünün merkezi konumundaki her tapınak, saray ve bunların etkisiyle oluşmuş kent ve kraliyet / saltanat bölgeleri, kutsal dağ sembolü ile nitelenir. Bununla birlikte, göğün direği (axis mundi) olarak imgelenmeleri nedeniyle üç kozmik alanın (gök, yer ve yeraltı) dikey eksende buluşma noktasını da yansıtırlar.
Bu öğretilerde, kutsal dağ veya kutsal ağaç ile simgelenen tapınak ve saraylar, mutlak gerçekliğin alanları olduklarından merkez sembolizminde önemli bir yere sahiptir. Bundan ötürü zikredilen yapılar, ‘âlemin göbeği’ olarak bilinirler. Diğer anlatımla, onlar, var oluş tarzları ile varlığın devamlılık ve tekâmülünü sağlayan tanrısal kaynaklardır. Klasik Türk şiirinde zaman zaman değer ve önem bakımından Kâbe’ye de benzetilen saray, son çözümlemede, tanrısal isim ve sıfatların tecelli noktası olan insan kalbinin/zihninin simgesidir. Dolayısıyla, bu mekânda bulunan sultan/sevgili de bilinç dışındaki gerçek benliğin imgesini temsil eder.
Public Awareness Campaigns Model of Global Civil Society at the Local Level: Case of Earth Hour Malang
Authors: Rijal Najamuddin Khairur , Widiatmojo Radityo
Published: October 2021

The purpose of this research is to elaborate the model of public awareness campaigns conducted by global civil society actors at the local level, with studies of Earth Hour Malang. Earth Hour Malang’s public awareness campaigns are related to efforts to fight for environmental issues to gain attention with the society and stakeholders. This research used the global civil society framework, specifically the public awareness campaigns (PAC), conducted through interviews and documentation studies on Earth Hour Malang Social media. Social media data is analyzed using the NCapture feature in the NVivo 12 Plus. The results showed that Earth Hour Malang integrates offline and online approaches through various instruments in conducting campaigns. The goal is to raise public, business, and government awareness of environmental issues, encourage changes in green lifestyle-oriented behavior, changes in business activity and orientation, and pro-environmental policy changes.Keywords: Earth Hour, environmental issues, global civil society, public awareness campaignsTujuan penelitian ini adalah mengelaborasi model kampanye kesadaran publik yang dilakukan oleh aktor global civil society di level lokal, dengan studi pada Earth Hour Malang. Kampanye kesadaran publik yang dilakukan Earth Hour Malang berkaitan dengan usaha memperjuangkan isu lingkungan agar dapat memperoleh perhatian bersama masyarakat dan pemangku kepentingan. Dengan menggunakan konsep global civil society dan public awareness campaigns, penelitian dilakukan melalui wawancara dan studi dokumentasi pada media sosial Earth Hour Malang. Data media sosial dianalisis menggunakan fitur NCapture pada aplikasi NVivo 12 Plus. Adapun hasil penelitian menunjukkan bahwa Earth Hour Malang mengintegrasikan pendekatan luring dan daring melalui beragam instrumen dalam melakukan kampanye. Tujuannya adalah menumbuhkan kesadaran masyarakat, sektor bisnis, dan pemerintah terhadap isu dan persoalan lingkungan sehingga mendorong perubahan perilaku masyarakat berorientasi gaya hidup hijau, perubahan aktivitas dan orientasi bisnis, serta perubahan kebijakan yang pro-lingkungan.Kata-kata Kunci: Earth Hour, global civil society, isu lingkungan, kampanye kesadaran publik
The Dynamics of Indonesia – Japan Economic and Financial Relations: A Review of the 60 Years Collaboration
Authors: Saputro Eko NM
Published: October 2021

Perkembangan hubungan ekonomi dan keuangan antara Indonesia dan Jepang telah berkembang di berbagai bidang dalam satu dekade terakhir. Lebih dari itu, kerja sama keduanya selalu menarik untuk dipahami mengingat tidak hanya melibatkan kepentingan ekonomi semata, namun juga aspek lain seperti pertimbangan politik dan sosial. Tulisan ini akan mencoba menjelaskan kerja sama ekonomi dan keuangan antara Indonesia dan Jepang. Berfokus pada sudut pandang Indonesia, analisis dalam tulisan ini menjelaskan mengenai bantuan pembangunan luar negeri, dukungan keuangan, investasi, dan hubungan perdagangan. Studi ini menemukan bahwa meskipun secara umum kerja sama ekonomi dan keuangan antara Indonesia dan Jepang telah relatif kuat, terdapat beberapa masalah terkait dengan investasi dan perdagangan, yang perlu ditangani.Kata-kata kunci: Hubungan Indonesia-Jepang, bantuan luar negeri untuk pembangunan, kerja sama keuangan, perdagangan bilateral, investasi Economic and financial ties between Indonesia and Japan have flourished in the recent decade covering many areas of cooperation. The cooperation between the two is interesting to explore since it involves economic interests and other aspects such as politics and social dynamics. From Indonesia point of view, this study attempts to shed light on recent economic-financial cooperation between Indonesia and Japan, particularly on overseas development assistance, financial supports, investment, and trade relations. It is found that while, in general, economic and financial cooperation between Indonesia and Japan has been relatively robust, there are some issues related to investment and trade that need to be addressed.  Keywords: Indonesia-Japan relations, overseas development assistance, financial cooperation, bilateral trade, investment
Effects of AMF on nutrient and stoichiometric characteristics in different organs of sunflower
Authors: Dai Feng-jun , Wang Yu-juan , Xia Peng-liang , Wu Qiang-sheng , Liu Chun-yan
Published: October 2021

In order to explore the effects of arbuscular mycorrhizal fungi (AMF) on growth and nutrient absorption for ornamental sunflowers, explain the related physiological mechanism, four species of AMF Acaulospora scrobiculata (AS), Diversispora spurca (DS), Funneliformis mosseae (FM) and Diversispora versiformis (DV) were selected, and inoculated into potted ornamental sunflower seedlings under greenhouse condition. Effects of AMF on growth, nutrient absorption and ion balance of ornamental sunflower were analyzed. Results showed that four different AMF could infect sunflower roots. In which, DS inoculation has the highest mycorrhizal colonization; whereas, the mycelial length of DV treatment in rhizosphere soil was significantly higher than the other three AMF treatments. Four kinds of AMF markedly decreased the fresh weight in roots and leaves, but significantly increase the fresh weight in flower discs. Furthermore, the four different AMF increased the nitrogen (N), phosphorus (P), potassium (K), calcium (Ca) and magnesium (Mg) contents in roots, leaves and flower discs of sunflower in varying degrees, meanwhile reduced the N:P and N:K in root and the flower discs. In addition, the four different AMF significantly reduced the sodium ion (Na+) concentration but significantly increased K+/Na+, Ca2+/Na+ and P/Na+ in flower discs. The correlation analysis showed that there was a significant positive correlation between the mycorrhizal infection rate and the content of P or K in roots, or P, K, Ca in leaves, or N, K in flower discs in various organs of sunflower. In short, AMF could promote ornamental sunflower growth by ameliorating nutrient absorption and transport, adjusting the distribution of mineral elements in organs and the balance between ions, to enhance adaptability and ecological benefits.
Sustainable Partnerships in Cassava Production and Industrial Sector: A Heckprobit Analysis of Indonesian Farmers
Authors: Ibnu Muhammad
Published: October 2021

Partnerships are instruments to overcome the inability of individual smallholders to solve the development problems associated with agricultural sectors and commodity chains. While vigorously advocated, a sustainable partnership is rare in the Indonesian cassava production and industrial sector. Knowledge of partnership from the sector is also limited. This study explores the reasons for previous partnerships in the cassava production and industrial sector discontinued and examine what factors determine farmers' willingness to partake in partnerships. The study administered a systematic random sampling to survey for 140 cassava farmers in Central and East Lampung Districts from November 2018 to April 2019. Farmers were interviewed and given a structural questionnaire. The quantitative data were analyzed by heckprobit regression. The results of the study show that the partnership ends because the two parties do not have the same vision for working together. Various variables (barriers to selling to non-industries, low prices, inaccurate weighing scales, high transaction costs, and discounted prices.) indicate the complexity of farmers' considerations for joining the partnership. This research impliesthat it is difficult to create partnerships in the future if farmers and industry have different visions and priorities.
Blue economy prospect, opportunities, challenges, risks, and sustainable development pathways in Bangladesh
Authors: Bhuyan Md. Simul , Islam Md. Nazrul , Ali Mir Mohammad , Rashed-Un-Nabi Md. , Alam Md. Wahidul , Das Monika , Roy Ranjan , Das Mohan Kumar , Mojumder Istiak Ahamed , Mustary Sobnom
Published: October 2021

Blue economy worked as a policy tool or sustainable marine economic development model that drives economic growth and creates jobs. Human civilization is indebted to the oceans from decade to decade since the ocean is a vital source of food, energy, and minerals. It acts as the primary medium upon which global trade (e.g., seaborne international trade) takes place. Being an ocean-based country, Bangladesh has immense potential to be an advanced country by the year 2041. Sustainable use of blue economic development is must be ensured to achieve developed status. Lack of strong marine policy, weak ocean governance, and unsustainable use (e.g., IUU fishing, marine pollution, haphazard tourism, and unplanned coastal development) can be the huge risk factor for the effective execution of the blue economy. Blue economic development should be in an eco-friendly way and a special focus must be on the conservation of the marine ecosystem. A blue economy roadmap is necessary to provide a comprehensive strategy to ocean-based sustainable development that brings together the economy, environment, and society closely linked to the UN 2030 Sustainable Development Goals (SDGs). The shift to a Blue Economy will require profound and structural changes in the regulatory-management-governance policy process using the ecosystem-based Marine Spatial Planning method. For sustainable Blue Development, strong ocean policy and ocean governance must be ensured.
Analysis of PCDDs/PCBs by AhR-CALUX assay in Indian dietary food and environment ash
Authors: Murugasamy Mayilsamy , Seethappan Sangeetha , Ko Shunkei , Nakamura Masafumi , Govarthanan Muthusamy , Krishnamoorthi Vimalkumar
Published: October 2021

This study found distribution of polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans (PCDD/Fs) and dioxin like polychlorinated biphenyls (DL-PCBs) in bovine milk and ash samples collected from 9 different major districts namely Erode, Salem, Namakkal, Coimbatore, Trippur, Madurai, Chennai, Dindigul and Tiruchirappalli, which were highly populated and industrialized districts of South India (Tamil Nadu). The total toxic equivalency (TEQ) for PCDD/Fs and DL-PCBs in the bovine milk samples were ranged from 0.028 to 7.331-pg TEQ/g fat. Some of the districts showed higher PCDD/Fs and DL-PCBs concentration in milk and ash samples. Further, BM14 (7.331 pg-TEQ/g fat) and BM21 (6.406 pg-TEQ/g fat) sampling sites showed exceed level of PCDD/Fs and DL-PCBs than WHO regulation limits (6 pg-TEQ/g fat). Similarly, Total dioxins and DL-PCBs concentration in the ash sample were between 0.003-1. ng TEQ/g. Samples from AS3 (1.2 ng-TEQ/g) and AS11 (1.06 ng-TEQ/g) showed higher total dioxins and DL-PCBs level among other sampling sites. This study provides an overview of dioxins and dioxin-related compounds contamination in bovine milk and ash samples in south Tamil Nadu. Further, the CALUX assay method validation has simplified the monitoring of dioxin contamination in the environment.
Ketamine for Acute Pain After Trauma: KAPT Trial
Authors: Puzio Thaddeus J , Klugh James , Wandling Michael W , Green Charles , Balogh Julius , Prater Samuel J , Stephens Christopher T , Sergot Paulina D , Wade Charles E , Kao Lillian S , Harvin John A
Published: October 2021

BackgroundEvidence for effective pain management and opioid minimization of intravenous ketamine in elective surgery has been extrapolated to acutely injured patients, despite limited supporting evidence in this population. This trial seeks to determine the effectiveness of the addition of sub-dissociative ketamine to a pill-based, opioid-minimizing multi-modal pain regimen (MMPR) for post traumatic pain.MethodsThis is a single-center, parallel-group, randomized, controlled comparative effectiveness trial comparing a MMPR to a MMPR plus a sub-dissociative ketamine infusion. All trauma patients 16 years and older admitted following a trauma which require intermediate (IMU) or intensive care unit (ICU) level of care are eligible. Prisoners, patients who are pregnant, patients not expected to survive, and those with contraindications to ketamine are excluded from this study. The primary outcome is opioid use, measured by morphine milligram equivalents (MME) per patient per day (MME/patient/day). The secondary outcomes include total MME, pain scores, morbidity, lengths of stay, opioid prescriptions at discharge, and patient centered outcomes at discharge and six months.DiscussionThis trial will determine the effectiveness of sub-dissociative ketamine infusion as part of a MMPR in reducing in-hospital opioid exposure in adult trauma patients. Furthermore, it will inform decisions regarding acute pain strategies on patient centered outcomes.Trial Registration:The Ketamine for Acute Pain Management After Trauma (KAPT) with registration # NCT04129086 was registered on 10/16/2019 and is available at https://clinicaltrials.gov/ct2/show/NCT04129086?term=ketamine+injury&draw=2&rank=6
A Compact Asymmetrically Slotted Antipodal Vivaldi Antenna for MIMO Imaging Systems.
Authors: ZIANI Djamila , MERIAH Sidi Mohammed , DERRAZ Foued , MERAD Lotfi
Published: October 2021

In this paper, we propose a Compact Asymmetrically Slotted Antipodal Vivaldi Antenna (CAS-AVA) design for MIMO imaging systems. The structure has the ability to extend the antenna bandwidth in low-end frequencies achieving a fractional bandwidth of 123,32 % (4.743-20 GHz). Good results are obtained in term of return loss, radiation pattern and gain. A time-domain study has been also performed to characterize the antenna behavior in case of an UWB pulse is used. To further validate our design, an application for MIMO imaging system is also proposed and evaluated. The antenna performances demonstrate that it is a good candidate for microwave imaging applications.
A novel method for the synthesis of MOF-199 for Sensing and Photocatalytic Applications
Authors: Garg Deepika , Rekhi Heena , Kaur Harpreet , Singh Karam Jeet , Malik Ashok Kumar
Published: October 2021

Multifunctional Cu (II)-based Metal Organic Framework (MOF) [Cu3(BTC)2] has been synthesized by a facile electrochemical method. Crystallographic and morphological characterizations of synthesized MOF have been done using Powder X-ray Diffractometer and Scanning Electron Microscope (SEM), respectively, whereas Fourier Transform Infrared Spectroscopy (FT-IR), Energy Dispersive X-ray Spectroscopy (EDS), UV-Vis Absorption Spectroscopy and Energy Resolved Luminescence Spectroscopic studies have been used for the detailed qualitative, quantitative as well as optical analyses. Sharp PXRD peaks indicate the formation of highly crystalline MOF with face centered cubic (fcc) structure. Flakes (average length = 0.71µm and width = 0.10 µm) and rods (average aspect ratio = ((0.1:8.3) µm) like morphologies have been observed in SEM micrographs. The presence of C, O and Cu has been confirmed by EDS analysis. Photocatalytic activity potential of the synthesized MOF has been tested using methylene blue dye (MB) as a test contaminant in aqueous media under sunlight irradiation. Selective and sensitive fluorescent sensing of different Nitroaromatic compounds (NACs) like 4-Nitroaniline (4-NA), 2-Nitroaniline (2-NA), 3-Nitroaniline (3-NA), 4-Nitrotoulene (4-NT), 2,4-Dinitrotoulene (2,4-DNT), 1,3-Dinitrobenzene (1,3-DNB), 2,6-Dinitrotoulene (2,6-DNT) has been done by exploring the photoluminescent behaviour of chemically stable Cu3(BTC)2. Synthesized MOF is extremely sensitive towards 4-NA, which is having PL quenching efficiency of 82.61% with highest quenching rate till reported. Indeed, a large quenching coefficient KSV = 34.02 x 10− 7 M− 1 and correlation coefficient R2 = 0.9962 in KSV plot have been elucidated with limit of detection (LOD) = 0.7544 ppb. The possible ways of luminescence quenching are successfully explained by the combination of Photoinduced Electron Transfer (PET) and Resonance Energy Transfer (RET) mechanisms. Additionally, the Density Functional Theory (DFT) calculations have been employed to support the experimental results. Cu3(BTC)2 fully demonstrates the power of a multi component MOF, which provides a feasible pathway for the design of novel material towards fast responding luminescence sensing and photocatalytic degradation of pollutants.
Changes of Network Structure and Water Distribution in Sludge With the Stratiﬁed Extraction of Extracellular Polymeric Substances
Authors: Lin Feng , Li Bingyun
Published: October 2021

For illustrating how extracellular polymeric substance (EPS) affected sludge water distribution, the present work comprehensively analyzed change of viscoelasticity and sludge network structure before/after EPS extraction, together with the sludge dewaterability and water distribution after biological, chemical and physical method conditioning. The results suggested the proportion of capillary water and adsorption water carried in soluble EPS (S-EPS) was 59.17% and 40.83%, and that in tightly-bound EPS (TB-EPS) was 54.77% and 45.23%, respectively. By contrast, the capillary water in loosely-bound EPS (LB-EPS) accounted for as high as 99.99%. Relative to raw sludge, adsorption water proportion in TB-EPS and S-EPS was reduced after lysozyme (LZM) or freezing-thaw conditioning, which was ascribed to reduction of EPS viscosity and the weakness of water adsorption capacity. Additionally, the sludge yield stress (τy) value first reduced and then increased with the extraction of EPS, and the consistency coefficient (k) also decreased from 4.23 Pa·sn to 0.006 Pa·sn and then slightly increased after LZM conditioning. This observation indicated the sludge system became sensitive to shearing, and its network structural strength as well as colloid elasticity first weakened and then slightly strengthened. What’s more, after LZM or freezing-thaw conditioning, the sludge particle size significantly increased after TB-EPS extraction, while the sludge particle more easily absorbed water molecules, leading to the increase of the capillary water and adsorption water in sludge flocs. These changes reasonably explained the reason that sludge filtration performance was deteriorated after TB-EPS extraction.
NanoRTax, a real-time pipeline for taxonomic and diversity analysis of nanopore 16S rRNA amplicon sequencing data
Authors: Rodriguez-Perez Héctor , Ciuffreda Laura , Flores Carlos
Published: October 2021

The study of microbial communities and their applications have been leveraged by the advances in sequencing techniques and bioinformatics tools. The Oxford Nanopore Technologies long read sequencing by nanopores provides a portable and cost-efficient platform for sequencing assays opening the possibility of its application outside specialized environments and real-time analysis of data. To complement the existing efficient library preparation protocol with a streamlined analytic workflow, here we present NanoRTax, a nextflow pipeline for nanopore 16S rRNA amplicon data that features state-of-art taxonomic classification tools and real-time capability. The pipeline is paired with a web-based visual interface to enable user-friendly inspections of the experiment in progress.
Data Fusion For Intelligent Decision Making in Agriculture Resource Management
Authors: R Dhaya , R Kanthavel , Venusamy Kanagaraj
Published: October 2021

The Agricultural Resource Management System (ARMS) is an information system that geographically permits farmers to classify their field and farm animals’ for making services in terms of setting up resources, increasing their ecological Farm Plan, food traceability, and animal physical condition. It is a tough task of planning the agricultural resources and making use of them effectively such as farm construction, tools utilization, fertilizer processing, management amenities, and use facilities which adds to the production, training, and marketing of crops. Apart from the fundamental property sunlight, soil, and water, the seeds and animal breeds, and human Endeavour also should be given more priority as agricultural resources. On the other hand, Agriculture Management System is the administration website to assist farmers in achieving high productivity and profitability to furnish efficient agricultural procedures through online selling of products. In order to attain the benefits and profits through agricultural resources, the Data fusion technique is used to integrate data and knowledge impending from several sources to acquire exact outcomes remotely. The purpose of this paper is to construct an intelligent decision-making Data fusion algorithm for proficient agriculture resource management. In addition, the analysis of challenges of the resource management and solutions also are rendered by taking agriculture land’s natural resources like water, air, and temperature level in winter and autumn seasons..
Assessment of Mouse VEGF Neutralization by Ranibizumab and Aflibercept
Authors: Ichiyama Yusuke , Matsumoto Riko , Obata Shumpei , Sawada Osamu , Saishin Yoshitsugu , Kakinoki Masashi , Sawada Tomoko , Ohji Masahito
Published: October 2021

There are many articles using bevacizumab, ranibizumab, and aflibercept as effective anti-vascular endothelial growth factor (VEGF) drugs in mice. However, it has been reported that bevacizumab lacks the ability to neutralize mouse VEGF. Here, we assessed the interaction between ranibizumab or aflibercept and mouse VEGF, both in vitro and in vivo. In vitro, we analyzed the interaction of mouse VEGF-A with aflibercept or ranibizumab as the primary antibody by Western blot, and observed immunoreactive bands for mouse VEGF-A in the aflibercept-probed blot, but not in the ranibizumab-probed blot. In vivo, we assessed the effect of intravitreal injection of ranibizumab and aflibercept on oxygen induced retinopathy and the effect of multiple intraperitoneal injections of ranibizumab and aflibercept on neonatal mice, and found that anti-VEGF effects were observed with aflibercept, but not with ranibizumab in both experiments. Our results suggest that aflibercept but not ranibizumab interacts with mouse VEGF. When conducting experiments using anti-VEGF drugs in mice, aflibercept is suitable, but ranibizumab is not.
Enhancement of Membrane Vesicle Production by Disrupting the degP Gene in Meiothermus Ruber H328
Authors: ASANO Yuki , ONISHI Manato , NISHI Kaito , KAWASAKI Kazunori , Watanabe Kunihiko
Published: October 2021

The phenomenon of membrane vesicle (MV) production is known to be common to all bacterial cells. Although MVs are expected to be employed in a variety of applications, improving MV productivity is essential for applications. Since the deletion of the degP gene, a periplasmic dual-function protease and chaperone, in Escherichia coli has successfully improved MV production capacity, we tried to enhance MV productivity in the thermophilic M. ruber H328 by deleting the degP gene. One gene (mrH_0331) was selected for degP gene from the H328 genome and we constructed the mutant strain DdegP by deleting the degP gene of the H328 strain that was replaced with the htk gene showing thermophilic kanamaycin resistance by homologous recombination. The mutant strain DdegP exhibited smooth growth but a lower level of turbidity at 60ºC although there was no difference in growth at 55ºC between the wild strain and the mutant strain. Finally, we have confirmed that incubation at 60°C increases MV in the mutant strain DdegP strain about fivefold by using two fluorescent dyes, DiI and FM4-64, which is followed by TEM analysis. The deletion of the degP gene presumably causes an increase in denatured proteins at 60°C, leading to enhanced MV production. Meanwhile, the S-layer protein included in the outer membrane of the H328 strain increased in the MV fraction prepared from the mutant cells incubated at 60°C. This indicates that this method is effective for MV production and that degP deletion enhances it in strain H328.
Today’s Referral Is Tomorrow’s Repeat Patient: Referrals Between Medical Outpatient Clinics in a Hospital
Authors: Safi Mariam , Clay-Williams Robyn , Thude Bettina Ravnborg , Vaisman Julija , Brandt Frans
Published: October 2021

Background Lack of understanding of inter-department and inter-speciality referral processes in Danish hospitals is contributing to unnecessary referrals and inefficient use of a health service already stretched and under pressure. An inefficient referral process is associated with over testing and repetitive testing, delayed treatment, patient confusion, ineffective use of physician and hospital service, and impaired patient outcomes. Despite a growing awareness in the literature and in practice of issues related to referrals, there has been relatively little research on referrals between specialists in hospital outpatient clinics and how it can be improved. This study aimed to describe the referral patterns to and within the Medical Department at the University Hospital of Southern Denmark. The Medical Department consists of the following medical specialist outpatient clinics: nephrology, pulmonology, endocrinology, cardiovascular, wound outpatient clinic, and a day hospital. Methods Two specialist physicians assessed all referrals to the medical specialist outpatient clinics over one month (from 01 September 2019 to 30 September 2019) using data drawn from the Danish electronic patient record system (Cosmic). Data on referral pattern, and patient age and sex, were statistically analysed to identify and characterise patterns of referral. Results 471(100%) referrals were included in the study. 49.5 % (233) of the referrals were from the hospital and 50.5 % (238) from general practitioners (GPs). Of the 233 referrals from the hospitals, 31% (72) were from the Medical Department.Conclusion The high rate of referrals from hospitals and referrals from own Medical Department or outpatient clinics illustrates the need for improvement on the inter-department referral process to provide joint care for multi-morbidity patients managed in multiple hospital outpatient clinics. Improved collaboration between specialists has the potential to improve health outcomes, timely access to care and more appropriate healthcare resource utilisation.
Vanillin Attenuates Pro-Inflammatory Factors in tMCAO Mice Model Via Inhibiting of TLR4/NF-kB Signal Pathway
Authors: Zhang Lei , Wang Ping , Li Chunyi , Liao Guolei , Huang Yihuan , Lv Xuxian , Liu Xudong , Chen Wenli
Published: October 2021

Purpose

Vanillin has been reported to reduce hippocampal neuronal death in rats of global cerebral ischemia. However, the immunoregulatory mechanism of vanillin in ischemic mice is still unclear. Hence, this study aims to investigate the role of vanillin in transient middle cerebral artery occlusion (tMCAO) mice.
Methods

Transient cerebral ischemic stroke was induced by tMCAO surgery following by reperfusion in mice. After 24 hours of ischemia/reperfusion, Berderson scoring and TTC staining were used to evaluate neurological deficit and infarct volume, respectively. Furthermore, the expression of cytokines in ipsilateral hemisphere were detected by qPCR, ELISA and immunofluorescence. In vitro, LPS-stimulated primary and BV2 microglia cells were used to mimic neuroinflammation after ischemic stroke. Similarly, the expression of cytokines was detected by qPCR and ELISA. In addition, Western blotting was performed to evaluate the expression of Toll-like receptor 4 (TLR4), nuclear factor-κ-gene binding p65 (NF-κB p65) and phosphorylated NF-κB p65.
Results

Vanillin reduced infarct volume and improved motor function after ischemia/reperfusion. IL-1β and TNF-α were decreased in ischemic brain tissue of tMCAO mice after vanillin treatment. Similar changes were confirmed using the in vitro LPS-stimulated microglia cell model. Moreover, the decreasing expression of pro-inflammatory cytokines in vanillin group were related to TLR4/NF-κB signal pathway.
Conclusions

Taken together, vanillin decreased activation of microglia by inhibiting TLR4 /NF-κB signal pathway, and then reduced expression of pro-inflammatory cytokines IL-1β and TNF-α, which finally reduced infarct volume and improve motor function in tMCAO mice.
Association Between HDL Cholesterol and Incident Cognitive Impairment in Black and White Adults in The Reasons For Geographic and Racial Differences in Stroke Study
Authors: Rosenson Robert , Cushman Mary , McKinley Emily C. , Muntner Paul , Wang Zhixin , Vaisar Tomas , Heinecke Jay , Tangney Christy , Judd Suzanne , Colantonio Lisandro D.
Published: October 2021

BACKGROUND:

Low levels of high-density lipoprotein cholesterol (HDL-C) have been associated with incident cognitive impairment (ICI) in some, but not all studies.
METHODS:

We examine the association between HDL-C and ICI among 18,378 Reasons for Geographic and Racial Differences in Stroke (REGARDS) study participants without cognitive impairment or stroke at baseline in 2003 to 2007, and who did not have a stroke event during follow-up.
RESULTS:

Over a median follow-up of 9.6 years, 1,359 participants developed ICI. In fully adjusted models, the RR for ICI was 1.51 (95% CI 1.06, 2.15) in White women and 1.25 (95% CI 0.95, 1.65) in Black women. The association was not statistically significant afrter adjustment for triglycerides. There was no evidence of an association between HDL-C and ICI among White or Black men.
CONCLUSIONS:

Low HDL-C was associated with a higher risk of ICI in White and Black women in models not including triglycerides.
A Visual Discrimination of Existing States of Virus Capsid Protein by a Giant Molybdate Cluster
Authors: Xue Yarong , Wei Mingfen , Fu Dingyi , Wu Yuqing , Sun Bo , Yu Xianghui , Wu Lixin
Published: October 2021

This study reports a unique phenomenon, the opposite color response of a giant polyoxometalate, (NH4)42[Mo132O372(CHCOO)30] (H2O)72 ([Mo132]), to the existing states of human papillomavirus (HPV) major capsid protein, L1-pentamer (L1-p) and virus-like particles (VLPs). The color responses originate from the different assembly forms between [Mo132] and the capsid protein, which were inspected and separated by using CsCl gradient centrifugation, and validated in detail by sodium dodecyl sulfate polyacrylamide gel-electrophoresis (SDS-PAGE), dynamic light scattering (DLS) and transmission electron microscopy (TEM) images. The intrinsic mechanism difference between them were investigated in depth by using the XPS-based semi-quantitative analysis and the well designed peptides, which reveal the key points of L1 determining the charge-transfer ratio between Mo(V) to Mo(VI), and consequently the levels of [Mo132] hypochromicity in different assemblies. Such unique phenomenon is significant as it supplies a colorimetry approach to directly distinguish the existing states of HPV capsid protein and would be significant in the quality assay of HPV vaccine and existing states of other virus in future.
Dissecting Impacts of Nutrition on Epistasis and Ethnicity-Specific Effects of Calibrated Factor VIII Level in the Multiethnic Study of Atherosclerosis
Authors: Alamin Md. , Zhu Jun , Lou Xiangyang , Xu Haiming
Published: October 2021

Background
Cardiovascular disease (CVD) is determined mainly by genetic predisposition and environmental factors such as diet. Factor VIII (FVIII) is an informative intermediate phenotype concerning atherosclerosis. An elevated plasma level of FVIII is considered a significant risk factor for CVD, providing an earlier subclinical measure to predict CVD liability. However, many studies have been investigated using the Multi-Ethnic Study of Atherosclerosis data, but very few studies have studied FVIII and nutrition factors together using a linear mixed model. A genome-wide association study (GWAS) was conducted using a mixed linear model including epistatic genetic effects, ethnicity-specific effects, and one cofactor (nutrition), aiming to investigate novel loci associated with Factor VIII level and the contribution due to the nutrition factor by comparing genetic effects of single nucleotide polymorphisms (SNPs) detected in the baseline and conditional models.
Results
A total of five quantitative trait SNPs at five genes have been identified in this study related to nutrition entirely or partially. One SNP (rs13428770) was associated with red blood cell count, two were in protein-coding genes, and the other two were in unknown non-coding RNA (ncRNA) genes associated with the FVIII level individually or epistatically. Two ethnicity-specific epistasis effect (rs17326624 × rs1468382) is identified in the European-American and African-American population. Bioinformatics analysis results showed that various Gene Ontology (GO) terms and pathways are associated with FVIII and nutrients in this study. The vital role of FVIII was further documented by the fact that the detected genetic factors are associated with CVD.
Conclusions
This study used a novel approach considering QTS by ethnicity interaction effects and applied conditional mapping by setting different kinds of nutrition as a cofactor in the statistic model. The nutrition factors strongly influence the genetic effects of detected SNPs, although the exact mechanism remains unidentified. This study offered that ethnicity-specific response needs to be considered in personal medical treatment and might reveal the impacts on specific QTS effects due to nutrition.
The “Direct Tip Injection in Occlusive Lesions (DIOL)” Fashion.
Authors: Haraguchi Takuya , Fujita Tsutomu , Kashima Yoshifumi , Masanaga Tsujimoto , Watanabe Tomohiko , Sugie Takuro , Hachinohe Daisuke , Kaneko Umihiko , Kobayashi Ken , Kanno Daitaro , Sato Katsuhiko
Published: October 2021

Background: The successful intervention for peripheral artery disease is limited by complex chronic total occlusions (CTOs). During CTO wiring, without the use of intravascular or extravascular ultrasound, the guidewire position is unclear, except for calcified lesions showing the vessel path. To solve this problem, we propose a novel guidewire crossing with plaque modification method for complex occlusive lesions, named the “Direct tip Injection in Occlusive Lesions (DIOL)” fashion.Main text: The “DIOL” fashion utilizes the hydraulic pressure of tip injection with a general contrast media through a microcatheter or an over-the-wire balloon catheter within CTOs. The purposes of this technique are 1) to visualize the “vessel road” of the occlusion from expanding a microchannel, subintimal, intramedial, and periadventitial space with contrast agent and 2) to modify plaques within CTO to advance CTO devices safely and easily. This technique creates dissections by hydraulic pressure. Antegrade-DIOL may create dissections which extend to and compress a distal lumen, especially in below-the-knee arteries. A gentle tip injection with smaller contrast volume (1-2 ml) should be used to confirm the tip position which is inside or outside of a vessel. On the other hand, retrograde-DIOL is used with a forceful tip injection of moderate contrast volume up to 5-ml to visualize vessel tracks and to modify the plaques to facilitate the crossing of CTO devices. Case-1 involved a severe claudicant due to right superficial femoral artery occlusion. After the conventional bidirectional subintimal procedure failed, we performed two times of retrograde-DIOL fashion, and the bidirectional subintimal planes were successfully connected. After two stents implantation, a sufficient flow was achieved without complications and restenosis for two years. Case-2 involved multiple wounds in the heel due to ischemia caused by posterior tibial arterial occlusion. After the conventional bidirectional approach failed, retrograde-DIOL was performed and retrograde guidewire successfully crossed the CTO, and direct blood flow to the wounds was obtained after balloon angioplasty. The wounds heeled four months after the procedure without reintervention.Conclusions: The DIOL fashion is a useful and effective method to facilitate CTO treatment.
Three Types Halogen Bond Interaction Studied Between Pyrazine And XF
Authors: Wu Junyong , Yan Hua , Chen Hao , Jin Yanxian , Zhong Aiguo , Wang Zhaoxu , Dai Guoliang
Published: October 2021

Except σ-type and π-type halogen bond, a new type of the parallel halogen bond interactions between pyrazine (C4H4N2) and XF (X=F,Cl,Br and I) have been discovered at the MP2/aug-cc-pVTZ level. Through comparing the calculated interaction energy,we can know that the π-type halogen bonding interactions are weaker than the corresponding σ-type halogen bonding interactions, and parallel halogen-bond interactions are weaker than the corresponding π-type halogen bonding interactions in C4H4N2-XF complexes. SAPT analysis shows that the electrostatic energy are the major source of the attraction for the σ-type halogen bonding interactions while the parallel halogen-bond interactions are mainly dispersion energy. For the π-type halogen bonding interactions in C4H4N2-XF(X=F and Cl) complexes, electrostatic energy are the major source of the attraction, while in C4H4N2-XF(X=Br and I) complexes the electrostatic term, induction and dispersion play equally important role in the total attractive interaction.NBO analysis, AIM theory and Conceptual DFT are also be utilized.