bluuebunny/crossref_metadata_2025 huggingface dataset:
General Oncology Care in Libya
Authors: Attia Adel , Siala Ismail , Azribi Fathi
Published: March 2022

Libya is a large country, ranking at fourth in terms of area both in the Arab world and the African continent (https://www.worldatlas.com/articles/which-are-the-10-largest-countries-of-africa-by-size.html). It is part of the World Health Organization–Eastern Mediterranean Regional Office (WHO–EMRO) region. Oil production is the main source of income which has transformed the country massively over the past 50 years and the healthcare system is one of the sectors that have improved significantly. The Health Act No (106), issued in 1973, guarantees free health services to all Libyans, with inevitable challenges regarding the delivery of adequate and sustainable services. The health system in Libya is a mix between the public sector and the private sector. The private sector is basically depending on funding through insurance companies and self-pay. It is not yet adequately developed but is striving and rapidly growing in the last two decades.

The oncology services are accessible and available for all Libyans, most of the diagnostic and therapeutic facilities are of good standards and the modern treatments like immunotherapy and targeted therapies are also available. However, there were periods when the health care system—in general—was struggling to meet the increasing demand on health services and has seen considerable challenges, especially over the past few years due to the conflict, political, and economic instability of the country. This chapter covers the oncology care in Libya, describing the current state, challenges, and future directions.
Inside the hologram: reconstructing the bulk observer’s experience
Authors: Jafferis Daniel Louis , Lamprou Lampros
Published: March 2022

Abstract

We develop a holographic framework for describing the experience of bulk observers in AdS/CFT, that allows us to compute the proper time and energy distribution measured along any bulk worldline. Our method is formulated directly in the CFT language and is universal: it does not require knowledge of the bulk geometry as an input. When used to propagate operators along the worldline of an observer falling into an eternal black hole, our proposal resolves a conceptual puzzle raised by Marolf and Wall. Notably, the prescription does not rely on an external dynamical Hamiltonian or the AdS boundary conditions and is, therefore, outlining a general framework for the emergence of time.
Large logarithms from quantum gravitational corrections to a massless, minimally coupled scalar on de Sitter
Authors: Glavan D. , Miao S. P. , Prokopec T. , Woodard R. P.
Published: March 2022

Abstract

We consider single graviton loop corrections to the effective field equation of a massless, minimally coupled scalar on de Sitter background in the simplest gauge. We find a large temporal logarithm in the approach to freeze-in at late times, but no correction to the feeze-in amplitude. We also find a large spatial logarithm (at large distances) in the scalar potential generated by a point source, which can be explained using the renormalization group with one of the higher derivative counterterms regarded as a curvature-dependent field strength renormalization. We discuss how these results set the stage for a project to purge gauge dependence by including quantum gravitational corrections to the source which disturbs the effective field and to the observer who measures it.
The influence of weight-bearing status on post-operative mobility and outcomes in geriatric hip fracture
Authors: Tarrant Seth Michael , Attia John , Balogh Zsolt Janos
Published: March 2022

Purpose

We hypothesized that unrestricted or full weight-bearing (FWB) in hip fracture would increase the opportunity to mobilize on post-operative day 1 (POD1mob) and be associated with better outcomes compared with restricted weight-bearing (RWB).

Methods

Over 4 years, 1514 geriatric hip fracture patients aged 65 and above were prospectively recruited. Outcomes were compared between FWB and RWB patients. The primary outcome was 30-day mortality. Secondary outcomes were immobility-related adverse events, length of stay (LOS), and reoperation for failure. Causal effect modelling and multivariate regression with mediation analyses were performed to examine the relation between weight-bearing status (WBS), POD1mob, and known mortality predictors.

Results

FWB was allowed in 1421 (96%) of 1479 surgically treated patients and RWB enforced in 58 (4%) patients. Mortality within 30 days occurred in 141 (9.9%) of FWB and 3 (5.2%) of RWB patients. In adjusted analysis, RWB did not influence 30-day mortality (OR 0.42, 95% CI 0.15–01.13, p = 0.293), with the WBS accounting for 91% of the total effect on mortality and 9% contributed from how WBS influenced the POD1mob. RWB was significantly related to increased DVT (OR 7.81, 95% CI: 1.81–33.71 p = 0.002) but no other secondary outcomes. Patients that did not have the opportunity to mobilize had increased 30-day mortality (OR 2.31, 95% CI 1.53–3.48 p < 0.001).

Conclusion

Restricted weight-bearing was not associated with increased 30-day mortality. Only a small proportion of this effect was mediated by POD1mob. Whilst post-surgical WBS may be difficult to influence for cultural reasons, POD1mob is an easily modifiable target that is likely to have a greater effect on 30-day mortality.

Level of evidence

Level III, observational study.
Re-rupture rate and the post-surgical meniscal injury after anterior cruciate ligament reconstruction with the Press-Fit-Hybrid®-technique in comparison to the interference screw technique: a retrospective analysis of 200 patients with at least 3 years follow-up
Authors: Volz Richard , Borchert Gudrun H.
Published: March 2022

Background

There is currently no consensus regarding the preferred surgical procedure for the reconstruction of anterior cruciate ligament (ACL). The interference screw technique is widely used, but has been associated with a risk of graft damage. The Press-Fit-Hybrid®-technique is one of the alternatives for biological ACL-reconstruction with minimal implant requirements. The hypothesis of this retrospective analysis is, that the Press-Fit-Hybrid®-technique leads to better results with respect to re-rupture rate and secondary meniscal lesion than the interference-screw-technique.

Methods

To compare the re-rupture rate of the interference-screw-technique (IF) used until 2015 with the currently used Press-Fit-Hybrid®-technique (PFH), the last 100 patients of the IF-group and the first 100 patients of the PFH-group were retrospectively analyzed. Primary outcomes were re-rupture rate, complications and secondary meniscal injury. Additionally, laxity, Lachman and Pivot-shift and range of motion were evaluated.

Results

A mean follow-up of 4.2 and 5.3 years revealed 4% and 9% re-rupture rates and 1% and 2% complication rates in the PFH- and IF-group, respectively. In the PFH-group there were no re-ruptures in patients older than 23 years. Secondary meniscal injury post-surgery was 6% and 9% for the PFH and IF-group, respectively. Knee stability was similar in both groups. Range of motion was significantly better in the PFH-group, with 136° of flexion, 6 months after surgery.

Conclusion

For ACL-reconstruction the Press-Fit-Hybrid®-technique is an alternative new method. Low level of secondary meniscal lesions after surgery and high stability, is known to prevent later arthrosis of the knee. The encouraging observed trend of the reduction of the re-rupture rate in revision surgery and in young patients using the Press-Fit-Hybrid®-technique in comparison to the interference-screw-technique must be confirmed with further studies.

Level of evidence

Therapeutic Level III, retrospective cohort study.
Influence of AFP on surgical outcomes in non-B non-C patients with curative resection for hepatocellular carcinoma
Authors: Tan Xiao-ping , Zhou Kai , Zeng Qing-li , Yuan Yun-fei , Chen Wei
Published: March 2022

To study the clinical and prognostic features of non-B non-C alpha-fetoprotein (AFP)(-)-hepatocellular carcinoma (HCC) (NBNC-AFP(-)-HCC) and the relationship between the prognostic features of HCC and hepatitis B virus surface antigen (HBsAg) status and AFP. We enrolled 227 patients who underwent hepatic resection for HCC between January 1998 and December 2007 at Sun Yat-sen University Cancer Center, all of whom were diagnosed with HCC by pathology. All patients were stratified into one of four groups (B-AFP(+)-HCC, B-AFP(-)-HCC, NBNC-AFP(+)-HCC, and NBNC-AFP(-)-HCC) according to AFP levels and HBsAg status. The clinicopathologic and survival characteristics of NBNC-AFP(-)-HCC patients were compared with those of all other three groups. Out of the 105 NBNC-HCC patients, 43 patients (40.9%) had AFP-negative HCC. There were some differences in factors between the B-AFP(+) and NBNC-AFP(-) patients, such as age, body mass index (BMI), diabetes, and ALT (P < 0.05). On univariate analysis, tumour size, secondary tumour, and portal invasion were prognostic factors for overall survival (OS) and disease-free survival (DFS) (P < 0.05). Cox multivariate regression analysis suggested that tumour size and tumour number (P < 0.05) were independent predictors. In addition, compared with the B-AFP(+)-HCC, B-AFP(-)-HCC, and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had the best DFS (P < 0.05). Compared with the B-AFP(+)-HCC and NBNC-AFP(+)-HCC groups, the NBNC-AFP(-)-HCC patients had better OS (P < 0.05), and survival rates were similar to those of B-AFP(-)-HCC patients. NBNC-AFP(-)-HCC patients had a relatively favourable prognosis. It can serve as a useful marker in predicting the risk of tumour recurrence in the early stages.
Combined Features in Region of Interest for Brain Tumor Segmentation
Authors: Alqazzaz Salma , Sun Xianfang , Nokes Len DM , Yang Hong , Yang Yingxia , Xu Ronghua , Zhang Yanqiang , Yang Xin
Published: March 2022

Diagnosis of brain tumor gliomas is a challenging task in medical image analysis due to its complexity, the less regularity of tumor structures, and the diversity of tissue textures and shapes. Semantic segmentation approaches using deep learning have consistently outperformed the previous methods in this challenging task. However, deep learning is insufficient to provide the required local features related to tissue texture changes due to tumor growth. This paper designs a hybrid method arising from this need, which incorporates machine-learned and hand-crafted features. A semantic segmentation network (SegNet) is used to generate the machine-learned features, while the grey-level co-occurrence matrix (GLCM)-based texture features construct the hand-crafted features. In addition, the proposed approach only takes the region of interest (ROI), which represents the extension of the complete tumor structure, as input, and suppresses the intensity of other irrelevant area. A decision tree (DT) is used to classify the pixels of ROI MRI images into different parts of tumors, i.e. edema, necrosis and enhanced tumor. The method was evaluated on BRATS 2017 dataset. The results demonstrate that the proposed model provides promising segmentation in brain tumor structure. The F-measures for automatic brain tumor segmentation against ground truth are 0.98, 0.75 and 0.69 for whole tumor, core and enhanced tumor, respectively.
Feather stable isotopes (δ2Hf and δ13Cf) identify the Sub-Saharan wintering grounds of turtle doves from Europe
Authors: Marx Melanie , Schumm Yvonne R. , Kardynal Kevin J. , Hobson Keith A. , Rocha Gregorio , Zehtindjiev Pavel , Bakaloudis Dimitris , Metzger Benjamin , Cecere Jacopo G. , Spina Fernando , Cianchetti-Benedetti Marco , Frahnert Sylke , Voigt Christian C. , Lormée Hervé , Eraud Cyril , Quillfeldt Petra
Published: March 2022

Conservation of migratory birds requires knowledge of breeding and nonbreeding ranges and the connections between them. European turtle doves (Streptopelia turtur) are Palearctic-African long-distance migrants with wintering areas in the Sub-Saharan belt that are classed as vulnerable due to strong population declines. However, detailed non-breeding locations of individuals from different migratory flyways are unknown. To identify wintering regions of turtle doves, we measured stable isotopes of feathers grown on the wintering grounds and used a dual-isotope (hydrogen (δ2Hf) and carbon (δ13Cf)) probabilistic assignment to analyse origins of individuals migrating through the western and central/eastern flyways. The most probable wintering areas for turtle dove samples from both flyways were in the western and central Sub-Sahara. However, we found differences in δ2Hf and δ13Cf values between turtle doves following different migratory routes (western vs central/eastern flyway). This result suggests a higher likelihood of origins in the central Sub-Sahara for central and eastern migrants, while turtle doves using the western flyway originated primarily in the western Sub-Sahara, highlighting the importance of both regions for the future conservation of turtle doves from European breeding populations. The establishment of migratory connectivity of populations requires sampling from birds from the European as well as Asian continent; however, we provide important results that can be used to test hypotheses regarding population declines resulting from factors experienced over the full annual cycle for some populations.
Associations Between Anxiety and Home Learning Difficulties in Children and Adolescents with ADHD During the COVID-19 Pandemic
Authors: Jackson Anna , Melvin Glenn A. , Mulraney Melissa , Becker Stephen P. , Bellgrove Mark A. , Quach Jon , Hutchinson Delyse , Westrupp Elizabeth M. , Montgomery Alicia , Sciberras Emma
Published: March 2022

The COVID-19 pandemic has markedly impacted functioning for children and adolescents including those with attention-deficit/hyperactivity disorder (ADHD). We explored home learning difficulties (HLD) during COVID-19 restrictions in Australian children (aged 5–17) with ADHD, aiming to: (1) describe home learning experiences, and (2) examine associations between child anxiety (i.e., concurrent anxiety symptoms and pre-existing anxiety disorder status) and HLD. Baseline data from the longitudinal ADHD COVID-19 Survey were used (n = 122). Parents reported on school factors and HLD; pre-existing anxiety and co-occurring difficulties; anxiety, ADHD, and oppositional symptoms; demographics; and medications. Parents retrospectively reported more children often looked forward to school pre-pandemic, than during the pandemic. Anxiety symptoms, but not pre-existing anxiety disorder status, were associated with HLD after accounting for covariates. ADHD inattention symptoms were also associated with HLD. Results support recommendations to continue pre-pandemic supports to assist with ADHD symptoms during home learning, and strategies/supports for families are discussed.
Elevated CD21low B Cell Frequency Is a Marker of Poor Immunity to Pfizer-BioNTech BNT162b2 mRNA Vaccine Against SARS-CoV-2 in Patients with Common Variable Immunodeficiency
Authors: Bergman Peter , Wullimann David , Gao Yu , Wahren Borgström Emilie , Norlin Anna-Carin , Lind Enoksson Sara , Aleman Soo , Ljunggren Hans-Gustaf , Buggert Marcus , Smith C. I. Edvard
Published: March 2022

Purpose

Limited data is available on the effect of COVID-19 vaccination in immunocompromised individuals. Here, we provide the results from vaccinating a single-center cohort of patients with common variable immunodeficiency (CVID).

Methods

In a prospective, open-label clinical trial, 50 patients with CVID and 90 age-matched healthy controls (HC) were analyzed for SARS-CoV-2 spike antibody (Ab) production after one or two doses of the Pfizer-BioNTech BNT162b2 mRNA vaccine. Additionally, in selected patients, SARS-CoV-2 spike-specific T-cells were assessed.

Results

A potent vaccine-induced anti-spike–specific IgG Ab response was observed in all the HC. In contrast, only 68.3% of the CVID patients seroconverted, with median titers of specific Ab being 83-fold lower than in HC. In fact, only 4/46 patients (8.6%) of patients who were seronegative at baseline reached the threshold for an optimal response (250 U/mL). Using the EUROclass definition, patients with either a reduced proportion, but not absolute counts, of switched memory B-cells or having an increased frequency of CD21lowB-cells generally generated poor vaccine responses. Overall, CVID-patients had reduced spike-specific IFN-γ positive CD4+T cell responses 2 weeks after the second dose, compared to HC. The total CD4 and CD4 central memory cell counts correlated with humoral immunity to the vaccine.

Conclusions

CVID patients with low frequency of switched memory B-cells or an increased frequency of CD21lowB-cells according to the EUROclass definition demonstrated poor responses to Pfizer-BioNTech BNT162b2 mRNA vaccination. Cellular immune responses were significantly affected, affirming that the defect in CVID is not limited to humoral immunity.
Gravity from Symmetry Breaking Phase Transition
Authors: Volovik G. E.
Published: March 2022

The paper is devoted to the memory of Dmitry Diakonov. We discuss gravity emerging in the fermionic vacuum as suggested by Diakonov 10 years ago in his paper “Towards lattice-regularized Quantum Gravity”. [1] Gravity emerges in the phase transition. The order parameter in this transition is the tetrad field $$e^a_\mu$$

e
μ
a

, which appears as the bilinear composite of the fermionic fields. The similar scenario of the symmetry breaking takes place in the B-phase of superfluid $$^3$$

3

He, where the real part of the spin-triplet p-wave order parameter matrix $$A_{a i}$$

A

ai

plays the role of the emerging tetrad (triad). In Diakonov theory this symmetry breaking gives 6 Nambu-Goldstone modes; 6 gauge bosons in the spin-connection fields, which absorb 6 NG modes and become massive gauge bosons; and 6 Higgs fields. In $$^3$$

3

He-B, these Higgs collective modes correspond to 6 massive gravitons, while in the emerging general relativity the Higgs collective modes give rise to two massless gravitational waves.
Moral Injury, Chaplaincy and Mental Health Provider Approaches to Treatment: A Scoping Review
Authors: Jones Kimberley A. , Freijah Isabella , Carey Lindsay , Carleton R. Nicholas , Devenish-Meares Peter , Dell Lisa , Rodrigues Sara , Madden Kelsey , Johnson Lucinda , Hosseiny Fardous , Phelps Andrea J.
Published: March 2022

The aim of this research was to describe the evidence examining the approaches taken by mental health providers (MHPs) and chaplains to address symptoms related to moral injury (MI) or exposure to potentially morally injurious events (PMIEs). This research also considers the implications for a holistic approach to address symptoms related to MI that combines mental health and chaplaincy work. A scoping review of literature was conducted using Medline, PsycINFO, Embase, Central Register of Controlled Trials, Proquest, Philosphers Index, CINAHL, SocINDEX, Academic Search Complete, Web of Science and Scopus databases using search terms related to MI and chaplaincy approaches or psychological approaches to MI. The search identified 35 eligible studies: 26 quantitative studies and nine qualitative studies. Most quantitative studies (n = 33) were conducted in military samples. The studies examined interventions delivered by chaplains (n = 5), MHPs (n = 23) and combined approaches (n = 7). Most studies used symptoms of post-traumatic stress disorder (PTSD) and/or depression as primary outcomes. Various approaches to addressing MI have been reported in the literature, including MHP, chaplaincy and combined approaches, however, there is currently limited evidence to support the effectiveness of any approach. There is a need for high quality empirical studies assessing the effectiveness of interventions designed to address MI-related symptoms. Outcome measures should include the breadth of psychosocial and spiritual impacts of MI if we are to establish the benefits of MHP and chaplaincy approaches and the potential incremental value of combining both approaches into a holistic model of care.
Landscapes for Neolithic People in Mainland, Orkney
Authors: Bunting M. Jane , Farrell Michelle , Dunbar Elaine , Reimer Paula , Bayliss Alex , Marshall Peter , Whittle Alasdair
Published: March 2022

Neolithic occupation of the Orkney Islands, in the north of Scotland, probably began in the mid fourth millennium cal BC, culminating in a range of settlements, including stone-built houses, varied stone-built tombs and two noteworthy stone circles. The environmental and landscape context of the spectacular archaeology, however, remains poorly understood. We applied the Multiple Scenario Approach (MSA) to Neolithic pollen records from Mainland, Orkney, in order to understand land cover and landscape openness across the timespan 4200–2200 cal BC. Interpreted within a framework provided by Bayesian chronological modelling, 406 radiocarbon dates from archaeological contexts and a further 103 from palaeoenvironmental samples provide the basis for the first detailed reconstruction of the spatio-temporal patterns of Neolithic people and their environment. Major alterations to the land cover of Mainland took place from 3400 cal BC (reduction in woodland from 20% to 10%) and from 3200 cal BC (increase in disturbed land from 3% to 30%). The dramatic increase in disturbed land coincided with the Grooved Ware phenomenon and the establishment of settlements at Skara Brae and Ness of Brodgar. The upturn in the signal for disturbance communities in the pollen record may indicate an increase in the amount of land used as pasture. This accords with the archaeological record, since the Neolithic Orcadian economy probably relied heavily on cattle for subsistence. By 2800 cal BC in the core of the Orkney Mainland, most settlements appear to have been ending, with people dispersing into the wider landscape, as the MSA modelling indicates a maintenance of disturbed land, and indeed a subsequent slight increase, implying persistence of human activity elsewhere in Mainland. People exhausted themselves rather than their land; that and its varied resources endured, while the intensive social relationships and practices of the peak of late Neolithic Orkney could not be maintained.
Approximate recoverability and relative entropy II: 2-positive channels of general von Neumann algebras
Authors: Faulkner Thomas , Hollands Stefan
Published: March 2022

We generalize our results in paper I in this series to quantum channels between general von Neumann algebras, proving the approximate recoverability of states which undergo a small change in relative entropy through the channel. To this end, we derive a strengthened form of the quantum data processing inequality for the change in relative entropy of two states under a channel between two von Neumann algebras. Compared to the usual inequality, there is an explicit lower bound involving the fidelity between the original state and a recovery channel.
Primary donor triplet states of Photosystem I and II studied by Q-band pulse ENDOR spectroscopy
Authors: Niklas Jens , Agostini Alessandro , Carbonera Donatella , Di Valentin Marilena , Lubitz Wolfgang
Published: March 2022

The photoexcited triplet state of the “primary donors” in the two photosystems of oxygenic photosynthesis has been investigated by means of electron-nuclear double resonance (ENDOR) at Q-band (34 GHz). The data obtained represent the first set of1H hyperfine coupling tensors of the3P700 triplet state in PSI and expand the existing data set for3P680. We achieved an extensive assignment of the observed electron-nuclear hyperfine coupling constants (hfcs) corresponding to the methine α-protons and the methyl group β-protons of the chlorophyll (Chl) macrocycle. The data clearly confirm that in both photosystems the primary donor triplet is located on one specific monomeric Chl at cryogenic temperature. In comparison to previous transient ENDOR and pulse ENDOR experiments at standard X-band (9–10 GHz), the pulse Q-band ENDOR spectra demonstrate both improved signal-to-noise ratio and increased resolution. The observed ENDOR spectra for3P700 and3P680 differ in terms of the intensity loss of lines from specific methyl group protons, which is explained by hindered methyl group rotation produced by binding site effects. Contact analysis of the methyl groups in the PSI crystal structure in combination with the ENDOR analysis of3P700 suggests that the triplet is located on the Chlaʹ (PA) in PSI. The results also provide additional evidence for the localization of3P680 on the accessory ChlD1in PSII.
Optimal Bayesian design for model discrimination via classification
Authors: Hainy Markus , Price David J. , Restif Olivier , Drovandi Christopher
Published: March 2022

Performing optimal Bayesian design for discriminating between competing models is computationally intensive as it involves estimating posterior model probabilities for thousands of simulated data sets. This issue is compounded further when the likelihood functions for the rival models are computationally expensive. A new approach using supervised classification methods is developed to perform Bayesian optimal model discrimination design. This approach requires considerably fewer simulations from the candidate models than previous approaches using approximate Bayesian computation. Further, it is easy to assess the performance of the optimal design through the misclassification error rate. The approach is particularly useful in the presence of models with intractable likelihoods but can also provide computational advantages when the likelihoods are manageable.
Optimal scaling of random walk Metropolis algorithms using Bayesian large-sample asymptotics
Authors: Schmon Sebastian M. , Gagnon Philippe
Published: March 2022

High-dimensional limit theorems have been shown useful to derive tuning rules for finding the optimal scaling in random walk Metropolis algorithms. The assumptions under which weak convergence results are proved are, however, restrictive: the target density is typically assumed to be of a product form. Users may thus doubt the validity of such tuning rules in practical applications. In this paper, we shed some light on optimal scaling problems from a different perspective, namely a large-sample one. This allows to prove weak convergence results under realistic assumptions and to propose novel parameter-dimension-dependent tuning guidelines. The proposed guidelines are consistent with the previous ones when the target density is close to having a product form, and the results highlight that the correlation structure has to be accounted for to avoid performance deterioration if that is not the case, while justifying the use of a natural (asymptotically exact) approximation to the correlation matrix that can be employed for the very first algorithm run.
Learning to solve ill-defined statistics problems: does self-explanation quality mediate the worked example effect?
Authors: Bichler Sarah , Stadler Matthias , Bühner Markus , Greiff Samuel , Fischer Frank
Published: March 2022

Extensive research has established that successful learning from an example is conditional on an important learning activity: self-explanation. Moreover, a model for learning from examples suggests that self-explanation quality mediates effects of examples on learning outcomes (Atkinson et al. in Rev Educ Res 70:181–214, 2000). We investigated self-explanation quality as mediator in a worked examples—problem-solving paradigm. We developed a coding scheme to assess self-explanation quality in the context of ill-defined statistics problems and analyzed self-explanation data of a study by Schwaighofer et al. (J Educ Psychol 108: 982–1000, 2016). Schwaighofer et al. (J Educ Psychol 108: 982–1000, 2016) investigated whether the worked example effect depends on prior knowledge, working memory capacity, shifting ability, and fluid intelligence. In our study, we included these variables to jointly explore mediating and moderating factors when individuals learn with worked examples versus through problem-solving. Seventy-four university students (mean age = 23.83, SD = 5.78) completed an open item pretest, self-explained while either studying worked examples or solving problems, and then completed a post-test. We used conditional process analysis to test whether the effect of worked examples on learning gains is mediated by self-explanation quality and whether any effect in the mediation model depends on the suggested moderators. We reproduced the interaction effects reported by Schwaighofer et al. (J Educ Psychol 108: 982–1000, 2016) but did not detect a mediation effect. This might indicate that worked examples are directly effective because they convey a solution strategy, which might be particularly important when learning to solve problems that have no algorithmic solution procedure.
Uphill Quenching to Reduce Residual Stress in Aluminium Alloy 7449 Hollow Structures
Authors: Robinson J. S. , O’ Donovan A. , Wimpory R. C.
Published: March 2022

Background

Uphill quenching (UHQ) of heat treatable aluminium alloy components is a long established but rarely practiced or investigated method of reducing residual stresses. The efficacy of the technique has not been quantified on thin walled structures before and this investigation will address that deficiency.

Objective

To quantify the impact of uphill quenching on thin walled structure with regards to residual stress and warpage, and compare and contrast to both quenching into cold water and a 30% polyalkylene glycol (PAG) solution.

Methods

Rectilinear hollow boxes were made from the very high strength aerospace aluminium alloy 7449. These were heat treated and aged using a variety of processing methods including uphill quenching from -196 °C to 100 °C using steam. Residual stresses have been characterised using neutron and x-ray diffraction.

Results

Compared to conventional quenching into cold water, both PAG and UHQ are shown to significantly lower the residual stresses. However, while PAG quenching results in a large uniform reduction in both residual stress and warpage, UHQ is much more localised and limited to regions adjacent to direct steam impingement. These regions are also warped. The depth of penetration of the stress relief during UHQ is shown to be 5 mm.

Conclusions

While uphill quenching is shown to be capable of locally stress relieving an aluminium alloy, it is far less effective compared to PAG quenching.
A sensitive, robust method for determining natural and synthetic hormones in surface and wastewaters by continuous solid-phase extraction–gas chromatography–mass spectrometry
Authors: Chafi Safae , Ballesteros Evaristo
Published: March 2022

Over recent decades, steroidal estrogens have become an emerging and very serious issue as they pose a serious threat to living organisms, soil, plants, and water resources in general. Estrogens have therefore been the subject of considerable scientific attention in order to develop new methodologies for its determination, being able of detecting them at very low concentrations. Those procedures minimize or eliminate the consumption of organic solvents and reagents that may be incompatible with the environment. In this respect, we developed a sensitive, selective method for the simultaneous determination of thirteen natural and synthetic hormones present at the nanogram-per-liter level in various types of water by using continuous solid-phase extraction in combination with gas chromatography and mass spectrometry (GC–MS). The target analytes were preferentially sorbed on an Oasis HLB sorbent column (80 mg) and eluted with acetone (600 µL) for derivatization with a mixture of 70 µL of N,O-bis(trimethylsilyl) trifluoroacetamide and trimethylchlorosilane and 35 µL of petroleum ether in a household microwave oven at 200 W for 4 min. Under optimum conditions, the ensuing method exhibited good linearity (r ≥ 0.998), good precision (RSD ≤ 7%), high recoveries (92–103%), and low detection limits (0.01–0.3 ng L−1). The method outperforms existing alternatives in robustness, sensitivity, throughput, flexibility—it allows both estrogens, progestogens, and androgens to be determined simultaneously—and compliance with the principles of Green Chemistry. It was successfully used to analyze various types of water samples (mineral, tap, well, pond, swimming pool, river, and waste) that were found to contain four estrogens (estrone, 17β-estradiol, 17α-ethinylestradiol, and hexestrol), two progestogens (testosterone, dihydrotestosterone), and one progestogen (progesterone) at concentrations ranging from 3.0 to 110 ng L−1.
Three-dimensional sinkhole stability of spherical cavity
Authors: Shiau Jim , Chudal Bishal , Keawsawasvong Suraparb
Published: March 2022

Sinkhole occurrences due to underground water mains operations have piqued people’s curiosity. Most research works were in relation to geophysical practices to discover the subsurface cavity. Very few works can be found in relation to the investigation of soil stability due to underground cavity shapes. The actual shape of an underground cavity and its transformation is difficult to predict, though the sinkhole failures are mostly circular in shape on the ground surface. This study explores the three-dimensional collapse stability of three distinct idealized cavity geometries, namely the circular, semi-spherical, and spherical cavities. For an active failure, dimensionless parameters are used to investigate the combined impacts of soil cover, surcharge pressure, soil weight, and internal pressure using advanced finite element limit analysis. Numerical results are compared with the two-dimensional axisymmetric results, and design charts presented to cover a wide range of design parameters for practical applications.
Was bedeutet Systemrelevanz in Zeiten der Pandemie?
Authors: Kaldewey David
Published: March 2022

Der Beitrag geht der Frage nach, was Systemrelevanz in Zeiten der Pandemie bedeutet und inwieweit „Systemrelevanz“ über die Pandemie hinaus zu einem Baustein der gesellschaftspolitischen Semantik des 21. Jahrhunderts werden könnte. Zur Beantwortung dieser Frage werden empirische, theoretische und gedankenexperimentelle Überlegungen verknüpft. Der erste Teil versteht Systemrelevanz als Akteurskategorie und untersucht die Karriere und die Bedeutungsverschiebung des Begriffs in verschiedenen diskursiven Kontexten. Der zweite Teil versteht Systemrelevanz als analytische Kategorie und diskutiert drei theoretische Perspektiven, die einhergehen mit der Etablierung quasi-soziologischer, im Alltag und in der Politik verwendbarer Beobachtungsschemata. Der dritte Teil schließlich widmet sich den konzeptionellen Herausforderungen der Soziologie während und nach der Pandemie. Ausgehend von einer Leerstelle des Systemrelevanz-Diskurses wird die These entwickelt, dass wir über Systemrelevanz nicht sinnvoll sprechen können, ohne zugleich über die erwartete oder geplante Dauer zu sprechen, mit der in Krisensituationen bestimmte Institutionen außer Betrieb genommen oder in einen Minimalbetrieb versetzt werden.
Microglia Modulate Cortical Spreading Depolarizations After Ischemic Stroke: A Narrative Review
Authors: Kearns Kathryn N. , Liu Lei , Soldozy Sauson , Sharifi Khadijeh A. , Shaffrey Mark E. , Park Min S. , Tvrdik Petr
Published: March 2022

Cortical spreading depolarizations (CSDs) are characterized by waves of diminished electroencephalography activity that propagate across the cortex with subsequent loss of ionic homeostasis. CSDs have been found in many pathological conditions, including migraine, traumatic brain injury, and ischemic stroke. Because of CSD-associated ionic and metabolic disturbances at the peri-infarct area after ischemic stroke, it is thought that CSDs exacerbate tissue infarction and worsen clinical outcomes. Microglia, the main innate immune cells in the brain, are among the first responders to brain tissue damage. Recent studies demonstrated that microglia play a critical role in CSD initiation and propagation. In this article, we discuss the significance of CSD in the setting of ischemic stroke and how microglia may modulate peri-infarct CSDs, also known as iso-electric depolarizations. Finally, we discuss the significance of microglial Ca2+ and how it might be used as a potential therapeutic target for patients with ischemic stroke.
Associations of home confinement during COVID-19 lockdown with subsequent health and well-being among UK adults
Authors: Shiba Koichiro , Cowden Richard G. , Counted Victor , VanderWeele Tyler J. , Fancourt Daisy
Published: March 2022

During the COVID-19 pandemic, the United Kingdom (UK) government introduced public health safety measures to mitigate the spikes in infection rates. This included stay-at-home orders that prevented people from leaving their homes for work or study, except for urgent medical care or buying essential items. This practice could have both short and long-term implications for health and wellbeing of people in the UK. Using longitudinal data of 10,630 UK adults, this study prospectively examined the association between home confinement status during the stringent lockdown in the UK (March 23-May 13, 2020) and 20 indicators of subjective well-being, social well-being, pro-social/altruistic behaviors, psychological distress, and health behaviors assessed approximately one month after the stringent lockdown ended. All analyses adjusted for socio-demographic characteristics and social isolation status in the beginning of the pandemic. Home confinement during the lockdown was associated with greater subsequent compliance with COVID-19 rules, more perceived major stressors, and a lower prevalence of physical activity. There was modest evidence of associations with lower life satisfaction, greater loneliness, greater depressive symptoms, greater anxiety symptoms, and more perceived minor stressors post-lockdown. However, there was little evidence that home confinement was associated with other indices of subsequent health and well-being. While our study shows that home confinement impacts some indices of subsequent health and wellbeing outcomes even after lockdown, the degree of the psychological adaptation to the difficult confinement behavior remains unclear and should be further studied.
The Cooperation Paradox
Authors: Clemons Eric K. , Schreieck Maximilian , Hermes Sebastian , Rowe Frantz , Krcmar Helmut
Published: March 2022

Dominant American online platforms like Amazon Alexa or Google Assistant have become Life Control Interfaces (LCIs), which facilitate consumers’ online interactions and influence what consumers do and do not see and buy. These platforms operate outside of EU regulation, and create significant costs for traditional European firms in a wide range of industries. These platforms can reduce firms’ access to customers, can charge for enabling access to customers, or can charge for access to essential data on firms’ customers. Since these platforms enjoy monopoly power there is little restraint on their charges, which indirectly increase consumers’ prices. We propose that regulators encourage the formation of a consortium to offer a single integrated EU-based Life Control Interface (EuLCI). This consortium would increase the number of EuLCIs from zero to one, and thus would actually increase consumer choice. We call cooperation that enhances rather than limits choice The Cooperation Paradox.
The risk-neutral non-additive probability with market frictions
Authors: Chateauneuf Alain , Cornet Bernard
Published: March 2022

The fundamental theory of asset pricing has been developed under the two main assumptions that markets are frictionless and have no arbitrage opportunities. In this case the market enforces that replicable assets are valued by a linear function of their payoffs, or as the discounted expectation with respect to the so-called risk-neutral probability. Important evidence of the presence of frictions in financial markets has led to study market pricing rules in such a framework. Recently, Cerreia-Vioglio et al. (J Econ Theory 157:730–762, 2015) have extended the Fundamental Theorem of Finance by showing that, with markets frictions, requiring the put–call parity to hold, together with the mild assumption of translation invariance, is equivalent to the market pricing rule being represented as a discounted Choquet expectation with respect to a risk-neutral nonadditive probability. This paper continues this study by characterizing important properties of the (unique) risk-neutral nonadditive probability $$v_f$$

v
f

associated with a Choquet pricing rule f, when it is not assumed to be subadditive. First, we show that the observed violation of the call–put parity, a condition considered by Chateauneuf et al. (Math Financ 6:323–330, 1996) similar to the put–call parity in Cerreia-Vioglio et al. (2015), is consistent with the existence of bid-ask spreads. Second, the balancedness of $$v_f$$

v
f

—or equivalently the non-vacuity of its core—is characterized by an arbitrage-free condition that eliminates all the arbitrage opportunities that can be obtained by splitting payoffs in parts; moreover the (nonempty) core of $$v_f$$

v
f

consists of additive probabilities below $$v_f$$

v
f

whose associated (standard) expectations are all below the Choquet pricing rule f. Third, by strengthening again the previous arbitrage-free condition, we show the existence of a strictly positive risk-neutral probability below $$v_f$$

v
f

, which allows to recover the standard formulation of the Fundamental Theorem of Finance for frictionless markets.
Is there a relationship between student attitudes and behavior regarding integrity issues?
Authors: Mol Hanneke , van den Hoven Mariëtte
Published: March 2022

Stimulating responsible conduct of research is considered important within universities and research organizations. In this contribution, we investigated if there are gender differences regarding three aspects: students’ attitudes towards integrity related issues, self-reported misconduct, and suspicions of misconduct and willingness to report fellow students. A questionnaire was sent to 1266 first year starting master students in the life sciences. Male students were significantly more likely to report not doing their fair share in group work and putting their name on work without checking it. No significant differences were found regarding attitude and suspecting and reporting other students.
Applications of machine learning to behavioral sciences: focus on categorical data
Authors: Dehghan Pegah , Alashwal Hany , Moustafa Ahmed A.
Published: March 2022

In the last two decades, advancements in artificial intelligence and data science have attracted researchers' attention to machine learning. Growing interests in applying machine learning algorithms can be observed in different scientific areas, including behavioral sciences. However, most of the research conducted in this area applied machine learning algorithms to imagining and physiological data such as EEG and fMRI and there are relatively limited non-imaging and non-physiological behavioral studies which have used machine learning to analyze their data. Therefore, in this perspective article, we aim to (1) provide a general understanding of models built for inference, models built for prediction (i.e., machine learning), methods used in these models, and their strengths and limitations; (2) investigate the applications of machine learning to categorical data in behavioral sciences; and (3) highlight the usefulness of applying machine learning algorithms to non-imaging and non-physiological data (e.g., clinical and categorical) data and provide evidence to encourage researchers to conduct further machine learning studies in behavioral and clinical sciences.
Critical Upper Airway Edema After a Bee Sting to the Uvula
Authors: Singer Eden , Lande Leah
Published: March 2022

Hymenoptera stings of the upper airway are rare events, but can result in rapid, life-threatening airway emergencies. The allergenic and toxic mediators that are released from the stings of bees, wasps, and hornets can cause local tissue inflammation and edema with subsequent upper airway obstruction. We report the case of a 15-y-old girl who suffered a bee sting to the uvula while zip-lining in Costa Rica. Shortly thereafter, she developed a choking sensation with associated dysphonia, odynophagia, drooling, and respiratory distress. She was brought to a rural emergency medical clinic where she was noted to have an erythematous, edematous, boggy uvula, with a black stinger lodged within it, as well as edema of the anterior pillars of the tonsils and soft palate. The stinger was removed with tweezers and she was treated with an intravenous corticosteroid and antihistamine. She had persistence of airway edema and symptoms until the administration of epinephrine, which resulted in clinical improvement shortly thereafter. In our review of this case and the existing literature, we emphasize the importance of early recognition and management of hymenoptera stings of the upper airway, which should always include immediate manual removal of the stinger, and in cases with significant upper airway edema, the administration of epinephrine should be considered.
Impact of Flood Due to Typhoon Hagibis on Cardiovascular and Cerebrovascular Events in the Disaster Area of Nagano City: A Sub-Analysis Using Data From the SAVE Trial
Authors: Komatsu Toshinori , Miura Takashi , Sunohara Daisuke , Yahikozawa Kumiko , Momose Tomoyasu , Kouno Tunesuke , Motoki Hirohiko , Mochidome Tomoaki , Kasai Toshio , Kuwahara Koichiro , Ikeda Uichi
Published: March 2022

Objectives:

This study aimed to examine the effects of flooding due to Typhoon Hagibis on the incidence of cardiovascular/cerebrovascular events in Nagano City.

Methods:

The SAVE trial retrospectively enrolled 2426 patients hospitalized for cardiovascular/cerebrovascular disease in 5 hospitals in Nagano City from October 1 to December 31 in 2017 and 2018 (pre-disaster period) and in 2019 (post-disaster period). From these, 280 patients who were hospitalized in a district flooded in 2019 were recruited for the same period (October 12 to December 31) over the 3 years. The baseline characteristics of and the incidence of cardiovascular/cerebrovascular disease in cases from the flooded district in 2019 were compared with those of cases in the flooded district in 2017 and 2018.

Results:

The total number of patients with acute myocardial infarction did not differ significantly between the post- and pre-disaster periods. The incidence of unstable angina pectoris was significantly higher in 2019 (n = 4, 5.1%) than in 2017 and 2018 (n = 0, 0.0%) (P = 0.001).

Conclusions:

This study did not prove the impact of flood due to a typhoon on the incidence of cardiovascular/cerebrovascular events.
Reactive scalars in incompressible turbulence with strongly out of equilibrium chemistry
Authors: Wu Wenwei , Wang Lipo , Calzavarini Enrico , Schmitt François G.
Published: March 2022

We study the statistical properties of scalar fields undergoing reversible chemical reactions in a turbulent environment by means of numerical simulations. To produce strong chemical fluctuations in a wide region of the domain, an original flow configuration has been proposed, where the species are supplied from buffer boundaries with adjustable thickness, while the flow is developed homogeneous and isotropic turbulence in a periodic domain. With the presence of the mean scalar gradient in the bulk region, the strength of turbulent advection is comparable with the chemical source, which is quantified by the Damköhler number. Our analysis focuses on the global and spatial properties of the reactive scalars in their statistically steady regime. We show how for the case of a second-order reaction such features can be connected to the properties of a non-reactive scalar field advected in the same system. Analytical predictions of the scalar moments in the fast reaction regime agree satisfactorily with the direct numerical simulation results. In comparison with the existing results of the isotropic turbulence case, we conclude that the scalar correlation is jointly determined by both the chemical source and the flow configuration. Moreover, the chemical reaction also plays an important role in determining the scalar energy spectra.