bluuebunny/crossref_metadata_2025 huggingface dataset:
การยอมรับและความลังเลในการฉีดวัคซีนป้องกันโรคโควิด-19 ของประชาชน ในอำเภอควนโดน จังหวัดสตูล
Authors: แก้วสองสี ชลลดา , คำกลั่น รสสุคนธ์ , ภัทราภินันท์ สถาพร
Published: February 2025

บทนำ: ในอำเภอควนโดน จังหวัดสตูล พบผู้ติดเชื้อโรคโควิด-19 สะสม จำนวน 862 คน ประชากรที่มีความประสงค์รับวัคซีนป้องกันโรคโควิด-19 ณ วันที่ 1 เมษายน 2565 จำนวน 16,898 คน คิดเป็น 62.05 % ของประชากรอำเภอควนโดนซึ่งถือว่าน้อยมากเมื่อเทียบกับจำนวนประชาชนทั้งอำเภอ วัตถุประสงค์เพื่อศึกษาการยอมรับและความลังเลในการฉีดวัคซีนป้องกันโรคโควิด-19 ของประชาชนในอำเภอควนโดน จังหวัดสตูล
วิธีการศึกษา: การศึกษาครั้งนี้เป็นการศึกษาเชิงวิเคราะห์ (Analytical study) แบบภาคตัดขวาง กลุ่มตัวอย่าง คือ ประชาชนอายุ 18 ปีขึ้นไป ตำบลควนสตอ อำเภอควนโดน จังหวัดสตูล จำนวน 443 คน สุ่มตัวอย่างแบบหลายขั้นตอน (Multi-stage sampling) เก็บรวบรวมข้อมูลด้วยแบบสอบถาม ตรวจสอบความตรงเชิงเนื้อหา (Content validity) โดยผู้เชี่ยวชาญ จำนวน 3 ท่าน ได้ค่า IOC เท่ากับ 0.91 วิเคราะห์ข้อมูลด้วยสถิติเชิงพรรณนา ได้แก่ ค่าความถี่ ค่าสัดส่วน ค่าเฉลี่ย ส่วนเบี่ยงเบนมาตรฐาน
ผลการศึกษา: กลุ่มตัวอย่างมีสัดส่วนการยอมรับวัคซีน ร้อยละ 50.1 มีความลังเลในวัคซีนร้อยละ 31.8 และ       ไม่ยอมรับวัคซีน ร้อยละ 18.1 ในกลุ่มตัวอย่างที่ยอมรับวัคซีนส่วนใหญ่เป็นผู้ที่ได้รับวัคซีนป้องกันโรคโควิด-19 แล้ว ร้อยละ 97.7 เหตุผลเพื่อสะดวกต่อการเดินทางและการดำเนินชีวิต ร้อยละ 44.7 ส่วนมากรับรู้ข้อมูลข่าวสารเกี่ยวกับโรคโควิด-19 จากแพทย์ ร้อยละ 63.4 กลุ่มตัวอย่างที่มีความลังเลวัคซีนส่วนมากเป็นผู้ที่ยังไม่ได้รับวัคซีน ร้อยละ 66.0 เหตุผล เนื่องจากไม่ประสงค์จะรับวัคซีน ร้อยละ 82.8 ส่วนมากรับรู้ข้อมูลข่าวสารเกี่ยวกับโรคโควิด-19 จากโซเชียลมีเดีย ร้อยละ 86.3 กลุ่มตัวอย่างที่ไม่ยอมรับวัคซีนส่วนใหญ่เป็นผู้ที่ยังไม่ได้รับวัคซีน ร้อยละ 98.8 เหตุผลเนื่องจากไม่ประสงค์จะรับวัคซีน ร้อยละ 93.7 รองลงมา คือ ไม่มั่นใจในวัคซีน ร้อยละ 3.8 และกลัวผลข้างเคียง ร้อยละ 2.5 ส่วนมากรับรู้ข้อมูลข่าวสารเกี่ยวกับโรคโควิด-19 จากครอบครัว/เพื่อน ร้อยละ 20.0
สรุปผล: กลุ่มตัวอย่างมีสัดส่วนการยอมรับวัคซีน ร้อยละ 50.1 มีความลังเลในวัคซีนร้อยละ 31.8 และ       ไม่ยอมรับวัคซีน ร้อยละ 18.1 เหตุผลสำคัญเกี่ยวข้องกับผลข้างเคียง และความปลอดภัยของวัคซีน ส่วนใหญ่แหล่งข้อมูลข่าวสารเกี่ยวกับโรคโควิด-19 ได้รับจากแพทย์ โซเชียลมีเดีย และครอบครัว/เพื่อน
พฤติกรรมการป้องกันตนเองในช่วงการแพร่ระบาดของโรคติดเชื้อไวรัสโคโรนา(COVID-19) ของประชาชนในอำเภอทุ่งหว้า จังหวัดสตูล
Authors: ปานศิริ กรรณิกา , สงเกิด วรนัฐ , ไชยจิตต์ อภิชาติ
Published: February 2025

บทนำ: สถานการณ์การติดเชื้อ COVID-19 ของจังหวัดสตูล เมื่อวันที่ 21 ตุลาคม 2564 พบยอดผู้ติดเชื้อสะสม 3,720 คน เสียชีวิตสะสม จำนวน 33 คน สำหรับอำเภอทุ่งหว้า จังหวัดสตูล มียอดผู้ติดเชื้อสะสม จำนวน 104 คน อย่างไรก็ตามถึงแม้ว่าจะมีการใช้มาตรการการป้องกันควบคุมโรคโดยเน้นสวมหน้ากาก ล้างมือบ่อยๆ และเว้นระยะห่าง รวมถึงหลีกเลี่ยงการสัมผัสจุดเสี่ยงที่สัมผัสร่วมกันบ่อยๆ แต่การระบาดของโรคก็ยังไม่มีอัตราที่จะลดลง ดังนั้นผู้วิจัยสนใจที่จะศึกษาปัจจัยที่มีความสัมพันธ์กับพฤติกรรมการป้องกันโรค COVID-19 ในอำเภอทุ่งหว้า จังหวัดสตูล
วิธีการศึกษา: เป็นการวิจัยเชิงวิเคราะห์แบบภาคตัดขวาง กลุ่มตัวอย่าง จำนวน 388 คน โดยใช้            วิธีการสุ่มตัวอย่างแบบมีระบบ เก็บรวบรวมข้อมูลด้วยแบบสอบถาม ตรวจสอบความตรงเชิงเนื้อหาจากผู้เชี่ยวชาญ จำนวน 3 คน ได้ค่า IOC เท่ากับ 0.95 ค่าความเที่ยงของเครื่องมือด้วยสัมประสิทธิ์อัลฟ่าของครอนบาคได้เท่ากับ 0.85 สถิติที่ใช้ ได้แก่ ร้อยละ ค่าเฉลี่ย ค่าเบี่ยงเบนมาตรฐาน ค่ามัธยฐาน ค่าต่ำสุด ค่าสูงสุด Chi-Square test และ Logistic regression
ผลการศึกษา: ปัจจัยที่มีความสัมพันธ์ต่อพฤติกรรมการป้องกันโรค COVID-19 อย่างมีนัยสำคัญทางสถิติ      (p-value < 0.05) ได้แก่ อายุระหว่าง 30-44 ปี (OR=2.0; p-value = 0.014) และทัศนคติของบุคคลต่อ    โรค COVID-19 (OR=2.0; p-value = 0.002) สำหรับเพศ อาชีพ สถานภาพ รายได้ การเข้าถึงข้อมูลข่าวสารเกี่ยวกับโรค COVID-19 และความรู้เกี่ยวกับโรค COVID-19 ไม่มีความสัมพันธ์ต่อพฤติกรรมการป้องกันโรค COVID-19 อย่างมีนัยสำคัญทางสถิติที่ระดับ 0.05
สรุปผล: อายุระหว่าง 30-44 ปี และทัศนคติของบุคคลต่อโรค COVID-19 มีความสัมพันธ์ต่อพฤติกรรมการป้องกันโรค COVID-19 ดังนั้นการสื่อสารองค์ความรู้ผ่านสื่อต่างๆ เป็นสิ่งสำคัญในการสร้างความเข้าใจ และปรับทัศนคติของประชาชนได้
Pengaruh Pupuk Organik Cair Limbah Tahu terhadap Pertumbuhan dan Produksi Jagung Pulut (Zea mays Ceratina)
Authors: Galushasti Andarula , Rahmawati Hidayatul , Soelaksini Liliek Dwi , Utami Christa Dyah
Published: February 2025

Corn is one of the food crops in Indonesia that has great potential to be developed, one of which is Waxy Corn. This type of corn has a high amylopectin content, but its productivity is still relatively low. One effort to increase the productivity of Waxy Corn is through the use of liquid organic fertilizer from tofu waste. This research was conducted on the land of the Jember State Polytechnic in July-October 2024 using a randomized block design with a single treatment, namely the comparison of the concentration of liquid organic fertilizer tofu waste. There are six treatment levels, namely control (0 ml/l), 26 ml/l, 28 ml/l, 30 ml/l, 32 ml/l, and 34 ml/l. The data were analyzed using analysis of variance, and if there was a significant difference, a further test of the smallest significant difference was carried out. The results showed that the treatment of liquid organic fertilizer with a concentration of 34 ml/l had a significant effect on the stem diameter at the age of 21 days after planting and the weight of the cob per sample. The concentration of 30 ml/l affected the cob diameter, while the concentration of 32 ml/l affected the cob weight per plot. The parameters of plant height and biomass weight did not show significant differences.
KREM-ATIR SOVUNLARNI KIMYOVIY TARKIBIGA KO‘RA TIF TN ASOSIDA SINFLASH
Authors: Yuldashev Shuhratbek Sherzodbek o'g'li , Asqarov Ibrohimjon Rahmonovich , Yo’lchiyev Aslbek Baxtiyorbekovich
Published: February 2025

Ushbu maqolada, noan’anaviy moyli xam-oshyolar asosida olingan krem-atir sovunlarni kimyoviy tarkibi bo‘yicha, TIF TN qoidala asosida sinflash hamda kod raqamlarini berish yuzasidan olib borilgan tadqiqot natijalari keltirilgan. Olib borilgan ilmiy-tadqiqot ishlarining natijasida anor danagi moyi, uzum danagi moyi xamda, sedana moylarini turli nasbatlarda kupajlangan moy kompozitsiyalari asosida olingan yangi krem-atir sovunlarga TIF TN bo‘yicha tovar kod raqamlarini berish tavsiya etilgan bo‘lib, bildirilgan takliflar eksport-import operatsiyalaridagi ayrim noaniqliklarni bartaraf etishga xizmat qiladi.
Mythes et « sentiment de fantastique » dans les littératures postcoloniales : Sony Labou Tansi, Maryse Condé
Authors: KIMPOLO Analyse
Published: February 2025

Associé le plus souvent à la dimension de création du sens qu’il peut donner à une culture, la notion du mythe donne également forme, par l’invention de certaines figures monstrueuses, à des terreurs et des horreurs liées à certains événements sociaux, culturels, historiques voire politiques. Plusieurs écrivains puisent régulièrement dans des mythes traditionnels, construisent et mettent en scène des personnages mythiques pour représenter et ou chercher à percevoir le rapport au réel. Dans cette perspective, Sony Labou Tansi et Maryse Condé procèdent d’une manière singulière. Ils articulent des inspirations basées sur la violence de la réalité et de l’histoire et les problématiques de la politique. Mythes et « sentiment de fantastique » dans La Vie et demie et dans Moi, Tituba sorcière… Noire de Salem, loin d’apporter des réponses à ces terreurs et horreurs contemporains, permettent au lecteur de partager avec les narrateurs l’horreur, l’épouvantable ou la sidération devant ce qui peut paraître comme impensable.
Keberhasilan Sistem Ekonomi yang Mengeluarkan Swedia dari Krisis Akibat Perang Dunia 1
Authors: Azizah Ratu Felita Abduh  , Nadhira Zahra Aulia Putri  , Vianna Antoneta Putri  , Muthia Nugraha
Published: February 2025

World War I was a global war that involved various countries in Europe along with Russia, the United States, the Middle East, and other regions. World War I was one of the turning points in the geopolitical history of the 20th century. The war led to the fall of four major imperial dynasties (in Germany, Russia, Austria-Hungary, and Turkey), which not only harmed the countries that participated in the war, but also other countries such as Sweden. Sweden made various efforts to keep its country afloat in a precarious situation. This article will explain how Sweden emerged from the economic crisis caused by World War I to become a prosperous country.
Seed priming with bacterial and fungal biocontrol agents alter physio-chemical parameters to suppress leaf rust disease in bread wheat
Authors: Razzaq Muhammad Usman , Shafique Ikhlas , Naz Effat , Jamil Shehnaz , Anas Muhammad , Javed Ayesha , Murtaza Umair , Abbas Amjad
Published: February 2025

Wheat (Triticum aestivum L.), a staple crop in Pakistan and the third most cultivated crop globally suffers yield losses of up to 60-70% due to leaf rust (Puccinia triticina). This study explored sustainable management strategies using biocontrol agents (Trichoderma sp. and Bacillus sp.) by seed priming across four different wheat varieties i.e., Arooj-22, Subhani-21, Punjab-11, and Shafaq-06. The experiment was conducted using a Complete Randomized Block Design (RCBD). Morphological parameters, including fresh and dry shoot/root weights, spike length, number and weight of seeds per spike, yield per plant, 1000-grain weight, shoot/root length, plant height, leaf area, peduncle length and awn length were assessed alongside physiological parameters such as malondialdehyde (MDA), hydrogen peroxide (H₂O₂), glycine betaine, chlorophyll content and free proline levels. Statistical analysis (ANOVA and LSD at 5% probability) revealed that Subhani-21 primed with Trichoderma sp. exhibited the best results by demonstrating reduced oxidative stress (lower MDA and H₂O₂ levels) and improved chlorophyll, glycine betaine, and free proline levels. These results highlighted the potential of eco-friendly treatments to mitigate leaf rust stress and enhancement of wheat growth and productivity.
Disciplina de pacientes com necessidades especiais nas faculdades de odontologia do estado de São Paulo
Authors: De Souza Joice Rodrigues , Felisardo Maria Gabriele Silva , Sarracini Karin Luciana Migliato , Neves Jose Guilherme , Marangoni Lopes Lenita
Published: February 2025

O objetivo do presente estudo foi avaliar a disponibilização da disciplina de pacientes com necessidades especiais (PNE) nos cursos de graduação em Odontologia do estado de São Paulo. Foi acessada uma tabela com os cursos de graduação em Odontologia ativos no estado de São Paulo e realizada uma busca da matriz curricular de cada curso. Informações como: natureza da instituição, presença da disciplina de pacientes especiais na matriz curricular, tipo de disciplina foram expressas em tabelas. Pode-se observar que a maioria das instituições (63%) oferecem a disciplina em sua matriz curricular, porém ainda existem um significativo número de cursos que não incluem PNE em sua grade, principalmente nas instituições públicas (50%). Os cursos que oferecem a disciplina, em sua maioria ofertam de natureza teórico-prática (54%), garantindo uma maior experiência do aluno com pacientes portadores de necessidades especiais já na graduação, sendo um diferencial na formação de profissionais na área odontológica, garantindo segurança ao cirurgião dentista e principalmente ao seu paciente. Pode-se concluir que vários cursos de graduação em odontologia no estado de São Paulo possuem o conteúdo de tratamento odontológico de pacientes com necessidades especiais na graduação, porém uma grande parcela ainda não possui este componente curricular.
QUALITY EVALUATION OF FLOUR AND BISCUIT PRODUCED FROM SWEET POTATO AND ORANGE POMACE
Authors: Arinola Stephen , O. Afolabi Omolara , V. Okunola Olutayo
Published: February 2025

This study exploited the food and functional potentials of orange pomace, a solid waste of orange juice production, in producing composite flours and acceptable biscuit. Orange pomace and sweet potato were processed into flour; at 0%, 5%, 10%, 15%, 20%, 25% and 30% levels, orange pomace flour was utilized to substitute sweet potato flour. Using conventional techniques, pasting and functional analysis were performed on the composite flours, likewise the proximate composition, antioxidant activity, physical characteristics and sensory acceptability of biscuits made from the composite flours were assessed. Wheat biscuit served as control. The pasting and functional qualities of the composite flours varied; addition of orange pomace considerably decreased peak viscosity (86.08 - 146.92 RVU) and breakdown viscosity (12.58 - 39.67 RVU) with varying impact on setback viscosity (43.00 - 62.75 RVU) and final viscosity (117.33 - 172.08 RVU). Biscuits produced from the composite flours were found to be significantly denser in ash (3.25 - 4.85%) and crude fibre (4.62 - 11.15%). The inclusion of orange pomace significantly increased DPPH, FRAP and total phenolic content with values ranging from 73. 23 to 83.44%, 4.85 to 9.92 mg vit. C/g and 17.93 to 24.75 mg GAE/g respectively. Biscuit produced from 85% sweet potato and 15% orange pomace composite flour showed significant higher acceptability and it compared favourably with the control. This study demonstrated that sweet potato-orange pomace composite flours could be used to make biscuits that people would find acceptable and that would support the waste-to-wealth drive as well as human fiber intake and its associated health benefits.
LOW-TEMPERATURE CATALYTIC OXIDATION OF WHITE SPIRIT VAPOR IN AIR BY BINARY OXIDES OF CUO-MNOₓ SUPPORTED ON OMS-2 MATERIAL
Authors: Huy Nguyen Nhat , Nguyen Ngo Quoc , Duy Hoang Cong Anh , Hang Vo Thanh , Thuy Nguyen Thi , Thuy Vo Thi Thanh
Published: February 2025

White spirit is mainly used as a solvent which contains volatile organic compounds (VOCs) that contribute to air pollution and pose health risks. In this study, the binary oxides of manganese and copper were prepared through a facile impregnation of the corresponding salts on a octahedral molecular sieve (OMS-2) and γ-Al2O3 was prepared via hydrothermal and calcination methods. The characteristics of materials were determined by BET, EDX, FTIR, XRD, and SEM analyses. Among the catalysts, CuO-MnOₓ/OMS-2 containing Cu/Mn mole ratio at 6:4, and the weight ratio of CuO and MnO with OMS-2 of 15 wt% provided the best performance for VOC removal, with an efficiency of 95%. Additionally, a durability test of the CuO-MnOₓ/OMS-2 catalyst showed that it can be a potential catalyst for low-temperature oxidation of VOCs in air.
Investigating a link between Glyphosate and Chronic Kidney Disease of Unknown Origin (CKDu) through Glyphosate’s interactions with Renal Proteins in Molecular Docking
Authors:   Duke University, Pirapaharan Vignesh
Published: February 2025

Chronic Kidney Disease of unknown origin (CKDu) is a subtype of chronic kidney disease that is mainly
observed in agricultural communities in Sri Lanka, India, and parts of Central America. The cases of CKDu in
agricultural settings are correlated with the use of pesticides. Among these, glyphosate, an herbicide, has been
shown to correlate with CKDu cases in Sri Lanka. Various mechanisms have been proposed for glyphosate’s
association with CKDu including the inhibition of CYP450 enzymes and the disruption of the renin-angiotensin-
aldosterone system. Given that glyphosate’s mode of action involves the binding to and inhibition of the protein
EPSP synthase, this study employs molecular docking to identify renal protein candidates with favorable binding
interactions with glyphosate at an atomic level. The results revealed that renal proteins such as interleukin-6,
uromodulin, and prorenin exhibited energetically favorable binding with glyphosate, potentially influencing the
prognosis of CKDu. In the future, it is necessary to experimentally validate these findings through in-vitro studies
to confirm glyphosate’s binding with these proteins of interest. The experimental validation could perhaps lend
insights into the etiology of the CKDu.
Ação docente e interação social: experiência no Estágio Supervisionado em Educação Infantil I
Authors: Cantu Mariana Brandão , Cabrioti Mariana Amalia da Costa , Arruda Viviane Aparecida Bernardes de , Barros Marta Silene Ferreira , Cabral Marina Colhado
Published: February 2025

Discussões relacionadas a ação docente, envolvendo a interação social, são consideradas imprescindíveis no cenário educacional atual, em especial na etapa da Educação Infantil, sendo ela a base para as etapas educacionais posteriores, cujo foco precisa ser na aprendizagem e no desenvolvimento das crianças. Nessa direção, mediante um olhar crítico-dialético, cabe questionar: Como a interação social e a ação docente contribuem para o desenvolvimento das crianças na Educação Infantil, à luz da Teoria Histórico-Cultural? Desse modo, buscar-se-á analisar os desafios e possibilidades observados no universo da Educação Infantil, durante o estágio supervisionado, além de averiguar de que forma a o trabalho pedagógico do professor, tendo o subsídio da teoria destacada, pode contribuir para a humanização da criança desde a tenra idade. O presente trabalho tem como metodologia a pesquisa bibliográfica, com autores que versam acerca da temática enunciada e está fundamentado no método crítico-dialético, envolvendo assim, os contributos da Teoria Histórico-Cultural. A pesquisa evidenciou a relevância da ação docente ter intencionalidade, ao se tratar do processo do ensino e do desenvolvimento das crianças, do mesmo modo que a interação social, sendo essa categoria primordial nesse processo de formação do psiquismo da criança. Mediante os desafios e possibilidades encontrados no campo de estágio, a formação do professor se destaca, sendo basilar, tanto em nível inicial, como contínuo, o que nesse sentido, abre caminhos para a ação e atuação docente que relaciona a teoria e a prática (práxis).
Crimes e infrações ambientais no Sudeste Paraense: seus aspectos e a legislação relacionada
Authors: Silva Elissandra Lima , Pontes Altem Nascimento , Paula Manoel Tavares de , Jesus Edimir dos Santos de , Terraza Werner Damião Morhy , Vieira Francilma Mendes Dutra
Published: February 2025

O presente estudo abrange as ocorrências de infrações e crimes ambientais nas microrregiões de Parauapebas e Marabá, no sudeste do estado do Pará. A metodologia utilizada baseia-se coleta de dados sobre infrações e crimes ambientais disponibilizados no PJE (TJ/PA, MP/PA, TRF1- Subseção Judiciária de Marabá), transparência SEMAS - Secretaria de Estado de Meio Ambiente e Sustentabilidade e nas Prefeituras, analisados quantitativamente. Também foi realizada uma revisão bibliográfica qualitativa para subsidiar as discussões sobre a aplicação da Lei nº 9.605/98 na área de estudo. Dessa forma, foram identificados as principais infrações e crimes ambientais mais recorrentes na região, sendo possível concluir que as infrações e crimes de maior incidência ocorreram contra a flora, no município de Marabá, praticados por pessoas física hipossuficientes, com resoluções de transação penal.
Utilização do método de perímetro molhado para cálculo de vazão de referência
Authors: Silva Taena Roberta Poeta Castilho da
Published: February 2025

O artigo abordou estratégias para estabelecer vazões mínimas de referência em corpos hídricos, com foco no Método do Perímetro Molhado. Destacou-se a análise do Método IFIM, ressaltando sua relevância complementar na definição dessas vazões, especialmente ao considerar aspectos ecológicos. Os resultados obtidos proporcionam insights significativos para aprimorar as políticas de gestão hídrica, enfatizando a importância de avaliações detalhadas na determinação das vazões de referência. A compreensão precisa das vazões mínimas é essencial para garantir a sustentabilidade dos ecossistemas aquáticos e o atendimento das demandas humanas relacionadas à água. Além disso, o estudo realçou a necessidade de abordagens integradas que considerem não apenas os aspectos hidráulicos, mas também os impactos ecológicos das alterações nos fluxos de água. Essas considerações são cruciais para promover uma gestão hídrica eficaz e equitativa, que concilie a conservação dos recursos naturais com o desenvolvimento humano. Assim, o estudo oferece um importante subsídio para a formulação de políticas e práticas de gestão hídrica mais sustentáveis e adaptáveis às complexidades dos sistemas aquáticos.
Optimizing Breast Cancer Prognosis with Machine Learning for Enhanced Clinical Decision-Making
Authors: Jagetiya Anurag , Dadhech Pankaj
Published: February 2025

Objective: Breast cancer remains a leading cause of mortality among women worldwide. Early detection and accurate prognosis are crucial for improving patient outcomes. This study presents a novel approach that integrates feature elimination techniques with machine learning to enhance the accuracy of breast cancer prognosis. The approach addresses class imbalance in the dataset to improve sensitivity, particularly in minimizing false negatives. Additionally, it emphasizes the use of machine learning algorithms, which are considered more transparent and computationally efficient compared to deep learning methods.
 Method: The Wisconsin Breast Cancer (WBC) dataset was used to develop an interpretable machine learning model. Recursive Feature Elimination (RFE) identified key features, while Principal Component Analysis (PCA) reduced dimensionality. The optimized feature set was trained using XGBoost. To address class imbalance, class weighting and decision threshold adjustments were applied to improve sensitivity and minimize false negatives
Results: The model achieved high performance: accuracy of 99.12%, precision of 100%, recall of 97.69%, and an F1 score of 98.9%. Feature selection and class imbalance handling enhanced sensitivity and computational efficiency. The model's interpretable results highlight its suitability for clinical applications.
Conclusions: This study presents an interpretable machine learning model integrating RFE, PCA, and XGBoost to enhance breast cancer prognosis. High accuracy and sensitivity, coupled with explainability, make it a promising tool for clinical decisionmaking in early detection and treatment planning.
Calibration of PALS System withCRM Materials for BiomedicalStudies
Authors: Kubat Karol , Kapłon Łukasz , Moskal Paweł , Stępień Ewa
Published: February 2025

Objective and method: Positron annihilation lifetime spectroscopy (PALS) is a powerfultechnique in material science that allows the investigation of the properties andbehavior of positrons in various materials. PALS can be used to investigate solidstructures at the nanometer scale and enable the use of positronium properties as anadditional diagnostic parameter. Here we present results from calibration of the PALSsystem with certificated reference materials (CRM).Materials: Source of 22Na covered with layer of Kapton film, and after that parafilm from both sides was used in all experiments. Certified materials of No_5602-a (polycarbonate) and No_5601-a (fused silica) were used to ascertain if parameters were correctly identified.Results: In an experiment three lifetime components were correctly identified. All of those components will always be present in the data in further experiments on biological samples. Lifetime components consist of: 196 ps for annihilations in AI an aluminium cover of the chamber, 386 ps for annihilations in thesource and in the Kapton foil, 463 ps for reactions with parafilm.Conclusions: These parameters will be further used to correctly identify positronlifetimes in biological samples. Recently, a new method for imaging of positroniumproperties was invented and the first in-vivo images of positronium lifetime in humanswere demonstrated with the multi-photon J-PET scanner. In order to correlate thepositronium properties in tissue with the medically useful parameters, and to translatepositronium imaging to clinics, comprehensive research of positronium properties inbiological samples is needed.
SARS-CoV-2 – the origin and spreadin the human population – Part 1.The origin and spread of SARS-CoV-2
Authors: Piwowar Monika Weronika , Ptak-Kaczor Magdalena , Dygut Jacek
Published: February 2025

Objective: This paper contains an overview of information related to the origin of the SARS-CoV-2 virus, its characteristics, including mutational variability, and monitoring the virus's presence in the human population.
Methods: A review of medical and biological literature from the PubMed/MEDLINE databases from 1998 to 2024 was performed regarding research on SARS viruses, particularly SARS-CoV-2.
Results and conclusions: At the end of 2019, cases of a new virus were recorded in China, which within a few months, as a result of free population migration, was transferred to various regions in the world. In the first quarter of 2020, the World Health Organization announced the SARS-CoV-2 pandemic. In addition to the characteristics of coronaviruses, headed by the SARS-CoV-2 virus, this manuscript contains several threads to provoke discussion, especially concerning the ethical aspects of “gain of function” research, which make pathogens more contagious, dangerous and lethal to humans. Attention is also paid to the essence of reliable work and documentation of scientific work.
СРАВНИТЕЛЬНАЯ ОЦЕНКА РЕЗУЛЬТАТОВ ЛЕЧЕНИЯ БОЛЬНЫХ С ВАРИКОЗНОЙ БОЛЕЗНИ НИЖНИХ КОНЕЧНОСТЕЙ
Authors: Болтаев Ахмаджон , Абдуллажанов Бахром
Published: February 2025

Актуальность. Из всех сосудистой системы, варикозная расширение вен нижних конечностей занимает первое место. Статистика показывает, что в развитых странах мира частота варикозной болезни составляет 25-33% среди женщин и 10-20% среди мужчин. В России только официально зарегистрировано более 38 млн человек, страдающих различными формами варикозной болезни, из которых у 15% имеются трофические расстройства. Целью данной научной работы явилось улучшение результатов лечения больных с различными формами варикозной болезни путем применения в комплексном лечении метода ЭВЛО. Материалы и методы. Авторы анализируют результаты лечения 267 больных с варикозной болезню нижних конечностей кторые были разделены на три группы. Первую группу составили 104 (38,9%) больных которым было проведено традиционная флебэктомия, вторую группу составили 107 (40,1%) больных которым было проведено ЭВЛО+минифлебэтомия большой подкожной вены одновременно и третую (основную) группу составили 56 (20,9%) больных которым было проведено ЭВЛО и через 3 месяца проведено склеротерапия или минифлебэктомия. Заключения. Эффективность того или иного варианта лечения варикозной болезни нижних конечностнй должна подтверждаться клиническими и инструментальными диагностическими методами, данными о частоте осложнений и рецидивов. Результаты исследования качества жизни несут ценную дополнительную информацию, позволяющую улучшить взаимодействие врача и пациента в достижении лучших результатов лечения.
Kajian Penentuan Modulus Elastisitas Baja dan Aluminium dengan Metoda Ultrasonic Pitch & Catch
Authors: Priambodo Toni Agung , Judawisastra Hermawan , Wirawan Riza
Published: February 2025

Modulus elastisitas adalah salah satu sifat material yang menyatakan nilai kekakuan dari material tersebut. Modulus elastisitas menunjukkan kemampuan material untuk menahan deformasi elastis saat diberi tegangan, yang mencerminkan hubungan antara tegangan dan regangan dalam batas elastisitas material tersebut. Metoda paling umum untuk menentukan nilai modulus elastisitas adalah dengan uji tarik tetapi masih mempunyai kekurangan harus merusak benda uji. Metoda uji tidak rusak yang dapat digunakan untuk menentukan nilai modulus elastisitas salah satunya adalah dengan menggunakan uji ultrasonik. Penentuan nilai modulus elastisitas dengan metoda ultrasonik pada material logam sudah dilakukan sebelumnya namun belum dapat menentukan nilai modulus elastisitas pada material pipa atau pada material dengan permukaan yang luas. Penelitian ini bertujuan mengkaji penentuan nilai modulus elastisitas pada material baja dan aluminium dengan metoda ultrasonik pitch & catch dengan variasi formula, variasi frekuensi probe dan variasi tebal benda uji. Validasi hasil uji dilakukan dengan membandingkan modulus elastisitas hasil metoda ultrasonik pitch & catch dengan modulus elastisitas dari referensi. Hasil penelitian menunjukkan bahwa variasi frekuensi probe, jarak antar probe dan tebal benda uji diatas 5mm menghasilkan nilai modulus elastisitas yang sesuai dengan referensi. Tebal benda uji dibawah 5mm menjadi batasan dari metoda ultrasonik pitch & catch dalam menentukan nilai modulus elastisitas karena data kecepatan gelombang longitudinal tidak akurat pada material yang tipis.
Diagnostiske kategorier brukt i kosmetisk medisin i Norge
Authors: Rikhardson Ingebjørn , Vogt Henrik
Published: February 2025

.
OPTICAL PROPERTIES OF CONVENTIONAL COMPOSITE RESINS COMPARED TO MONOCHROMATIC RESINS: A SYSTEMATIC REVIEW OF RANDOMIZED CLINICAL STUDIES
Authors: Torres Adriana da Silva , Terra Douglas Romaneli , Santos Jefferson Aguiar , Fehrenbach Júlia , Isolan Cristina Pereira , Guimarães Camila Pimenta de Araújo , de Araújo Cíntia Tereza Pimenta
Published: February 2025

The present work aimed to compare, through a systematic review of randomized clinical studies, the optical properties of monochromatic composite resins in comparison to conventional resins in permanent dentition. The selection of articles was carried out by two researchers independently, in the databases PubMed, Scopus, Web of science, Embase, Cochane and Google Scholar, in addition to a search in the list of references of the selected articles. Initially, articles were selected by title, followed by the summary and finally the full reading of the complete work. 239 articles were selected, after removing duplicates and selection criteria, only 3 articles were included in this review. The articles worked with class IV and class V enamel fractures. The resins used in the articles were different in each study, Admira Fusion X-tra x Admira Fusion; Omnichroma x Tetric-N-Ceram; Universal FiltekX Filtek Z350 XT. One study evaluated color matching, stability and marginal discoloration using the USPHS index (Alpha, Bravo and Charlie). The other evaluated color change using a digital spectrophotometer and the other article used modified USPHS criteria and digital photography. The majority of articles presented a low risk of bias and a high level of scientific evidence. It is concluded that the use of monochromatic resins demonstrated a satisfactory effect similar to that regarding color correspondence and stability when compared with conventional resin in classes V and in enamel fractures in class IV.
Evolution of treatment strategies for prostate cancer: a systematic review
Authors: Galarza Judith , Alarcón Daniel J. , Intriago Isaac E. , Zambrano Jeniffer M.
Published: February 2025

Introduction: Prostate cancer is one of the leading causes of morbidity and mortality in men, with prevalence and severity varying based on access to healthcare services and available treatment options. Objective: This systematic review aimed to explore the evolution of therapeutic strategies in the management of prostate cancer, evaluating the efficacy of different treatments and their impact on patients' quality of life. Methodology: A comprehensive search was conducted using Google Scholar, analyzing 22 selected articles after applying rigorous inclusion and exclusion criteria. Results: The findings indicate that androgen deprivation therapy, along with agents such as abiraterone and enzalutamide, has proven effective in managing hormone-sensitive and castration-resistant prostate cancer. Furthermore, second-generation antiandrogens and combination therapies with PARP inhibitors have demonstrated the ability to extend survival in specific cases. Conclusions: Immunotherapy, while showing limited benefits as a standalone treatment, exhibits greater efficacy when combined with other therapies, such as radiotherapy and chemotherapy. Nanomedicine remains an underdeveloped strategy but holds promise for enhancing the selectivity and efficacy of drugs in patients who have developed resistance to other treatments.
Health problems in the bijahual sugarcane community, ecuador
Authors: Cedeño Lahelya N. , Robles Jaime A. , Reina Juan D. , Vélez Valeria A. , Cordero Raúl A.
Published: February 2025

The study assessed the main health problems in the Cañales de Bijahual community, Manabí, Ecuador, to identify predominant conditions and associated factors. A cross-sectional design with qualitative and quantitative methods was used, involving a sample of 77 adult residents. Structured and semi-structured surveys were conducted in households, and a ranking of issues was carried out through brainstorming sessions with residents to prioritize the most urgent problems. The results revealed a high prevalence of hypertension and diabetes, affecting 22.08% and 20.78% of the population, respectively. The ranking identified the most critical issues as contamination from animal farming, the increase of ticks, and garbage accumulation, followed by excessive pesticide use and the rise of viral diseases. It was concluded that interventions are needed to improve environmental management and health programs.
Emerging from silence, Afro-Cubans in the colony
Authors: Mustelier Puig Vivian , Llamos Acosta Virgen Maite , Suárez Gómez Daiana
Published: February 2025

Colonial Cuban society was defined by the construction of models based on the color of people's skin, which led to the emergence of racist theories and white supremacy that justified the imposed system: slavery. In this sense, the economic and social situation of black women in Cuba was the most complex due to their opposition to the paradigms of power of the time. The research addresses elements of Cuban history from the end of the 18th century to the second half of the 19th century from a gender perspective. Hence, the general objective is aimed at analyzing the situation of Afro-descendant women in the context of colonial Cuba. The work was developed from a qualitative methodological perspective with the use of theoretical methods, where the bibliographic review was used as the main methodological strategy. The results obtained reflected how female identities were based on the intersection of multiple variables, legal status or degree of miscegenation, which resulted in the formation of racialized femininities, reflected in the painting of the time, especially in the work of Víctor Patricio de Landaluze. The experiences of Afro-Cuban women are a powerful testimony to human resistance and resilience. Studying them allows us to learn important lessons about the fight against oppression and discrimination, in the interest of building a more just and egalitarian society.
Afro hair as a symbol of resistance: the identity of black women and the practice of a counter-hegemonic aesthetic
Authors: Gonzalez Mina Daira Priscila
Published: February 2025

The experience of black women around image and aesthetics is a topic of great relevance; firstly because it is an issue with little scientific approach; second, because it invokes a critical reading of the different forms of oppression and historical invisibilization, to which they have been subjected from the hegemonic aesthetic, and third, because in these circumstances it is necessary to make visible the way in which women resist scenarios of racism, exclusion and denial, from different initiatives that are properly articulated to natural Afro hair and the relationship they build with it. In this order of ideas, this paper aims to present theoretical reflections on some processes of resistance, brokered by black Columbian women from their hair, as part of the vindication of their identity and positioning towards the hegemonic aesthetic. A qualitative methodology is proposed, which uses documentary review as a technique, in order to identify different initiatives that have been investigated from research processes, to evidence the construction of identity processes in black women from natural Afro hair. Within the discussions, the need to address from the academy, the contexts of discrimination and racialization suffered by black women from their hair, to elucidate the way in which they carry out actions of resistance and collective contestation as strategies that allow not only the conservation of historical memory from the meaning that hair represents, but also but also, the strengthening of ethnic/cultural identity.
The Role of Big Data in Enhancing Operational Efficiency
Authors: Olatunji Aishat Oluwatoyin
Published: February 2025

This review article examines the role of big data in enhancing operational efficiency by enabling real-time decision-making, predictive insights, and strategic optimization. The study aims to analyze how organizations leverage big data to improve efficiency, reduce costs, and enhance competitiveness. Exploding in volume, velocity, variety, and veracity, big data improves decision making processes through accurate prediction, fast action, and efficient resource usage across some industries like supply chain, healthcare, and finance. Using a structured review methodology, relevant literature, case studies, and empirical findings were synthesized to evaluate the impact of big data across industries such as supply chain management, healthcare, and finance. Findings reveal that predictive analytics enhances forecasting accuracy, while real-time analytics improves operational responsiveness. However, adoption challenges include high implementation costs, data privacy concerns, and integration complexities. The study highlights emerging solutions such as AI-driven automation, edge computing, and federated learning as critical enablers for overcoming these barriers. The insights presented offer practical implications for businesses seeking to optimize their data strategies and for researchers exploring advancements in big data applications. This paper also lays down the importance of integrating AI, IoT and Robotics to break constraints and work in synergy. The study provides directions for managers and scholars to fully capture the benefits of big data in improving organisational performance.
Marker Assisted Selection for Crop Improvement : A Review
Authors: Misra Ananya , Singh Rahul
Published: February 2025

Throughout the past ten years, there has been a significant increase in the number of papers discussing the creation and, to a lesser extent, the use of molecular markers in plant breeding. Nevertheless, the majority of the publications are the outcome of funding provided by sponsors with a mission for biotech advocacy or strategic science quality, which puts insufficient focus on the practical value of plant breeding. The resolution of several logistical and genetical constraints—which are hardly addressed in journal publications—is necessary to turn promising findings into practical implementations. Improvements in gene-based marker creation, more effective quantitative trait locus (QTL) mapping techniques, and more affordable genotyping systems are expected to raise the success rate. Crop development has undergone a revolution thanks to marker-assisted selection (MAS), which combines conventional breeding techniques with cutting-edge genetic technologies to increase the accuracy and effectiveness of choosing desired traits. This review paper offers a thorough analysis of MAS, emphasising its guiding concepts, methods, and practical uses in crop breeding initiatives. Breeders can expedite the breeding cycle by efficiently identifying and selecting for features like disease resistance, yield improvement, and abiotic stress tolerance at early embryonic stages by using molecular markers. The advantages and disadvantages of several marker types, such as single nucleotide polymorphisms (SNPs) and simple sequence repeats (SSRs), are covered in the paper. There are case studies that show how MAS can be successfully implemented in important crops like maize, wheat, and rice, and they also show how MAS may increase sustainability and production. Through marker-assisted selection, DNA markers have the potential to significantly increase the accuracy and efficiency of traditional plant breeding (MAS).
Neuropharmacological Evaluation of Ocimum sanctum and Coleus amboinicus in Experimental Model of Depression
Authors: Tony D.Eswar , Krishna K.Sai , Ramarao Nadendla
Published: February 2025

Objective: This study aimed to evaluate the antidepressant effects of a combination of Ocimum sanctum and Coleus amboinicus leaf extracts compared to amitriptyline using the tail suspension test (TST) and forced swim test (FST) in mice.
Background: Depression is a common mental health disorder marked by persistent sadness and loss of interest. While effective, current antidepressants like amitriptyline often cause side effects, leading to interest in natural alternatives. Ocimum sanctum and Coleus amboinicus have traditionally been used for their therapeutic, potentially antidepressant,   properties.
Methods: The study involved male mice, divided into groups receiving either a combination of Ocimum sanctum and Coleus amboinicus extracts at varying doses, amitriptyline, or a control. Antidepressant activity was assessed using the TST and FST, with decreased immobility time indicating antidepressant effects.
Results: The combination of Ocimum sanctum and Coleus amboinicus extracts significantly reduced immobility in the TST and FST, showing a dose-dependent antidepressant effect. At higher doses, it was comparable to amitriptyline, suggesting the extracts act through monoaminergic systems in the brain.
Conclusion: The combination of Ocimum sanctum and Coleus amboinicus extracts showed significant antidepressant activity, comparable to amitriptyline, in preclinical models. These findings suggest potential for use as alternative or complementary therapies for depression, with further research needed to confirm efficacy and safety in humans.
Formulasi dan Karakterisasi Sabun Padat Transparan Ekstrak Etanol Daun Jambu Biji (Psidium guajava L)
Authors: Rinaldi  , Adriani Azmalina , Aria Suzanni Mulia , Elfariyanti
Published: February 2025

Sabun padat transparan memiliki bentuknya yang menarik dengan aneka warna dan aroma. Sabun padat transparan memiliki busa lebih lembut, penampakan yang berkilau dan memiliki daya tahan yang lama. Sabun padat transparan dapat ditambahkan senyawa antioksidan, untuk memberi perlindungan terhadap kulit dari paparan radikal bebas. Penelitian ini bertujuan untuk mengetahui karaketerisasi sabun padat transparan ekstrak etanol daun Jambu biji (Psidium guajava L) pada konsentrasi ekstrak yang berbeda dan mengetahui sabun padat transparan memenuhi persyaratan uji. Penelitian ini bersifat eksperimental untuk memformulasikan ekstrak etanol daun jambu biji pada konsentrasi eksterak yang berbeda formula F1 (0,5%), F2 (1%), F3 (2%), F4 (4%), dan F5 (8%). Penelitian ini dilakukan pada bulan Oktober 2024 di Laboratorium AKAFARMA Banda Aceh. Daun jambu biji yang digunakan adalah daun jambu biji yang segar tidak layu, berwarna hijau; posisi daun nodus 3-5 dari pucuk. Daun diuji determinasi tanaman di BRIN. Sediaan sabun dari masing-masing formula diujikan secara organoleptis, pH, stabilitas busa, uji iritasi, Uji kelembaban dan uji hedonic. Hasil penelitian menunjukkan bahwa secara organoleptis ke-lima formula berbentuk padat transparan berbau khas ekstrak daun jambu biji dengan warna coklat – hitam. Nilai pH berkisar pH 9,8 – 10,2. Stabilitas busa F1 (81,3%), F2 (77,8%) F3 (86,7%), F4 (86,3%) dan F5 (90,0%). Semua sabun (formula F1-F5) tidak mengiritasi, tingkat kelembaban berkisar antara 2,5% - 6%. Dari semua formula sabun, formula F1 (0,5%) lebih disukai responden karena sediaan yang dihasilkan berbentuk padat yang lebih transparan dan warna yang terang (coklat muda). Sehingga dapat disimpulkan bahwa ekstrak etanol daun jambu biji (Psidium guajava L.) dapat diformulasikan kedalam sediaan sabun padat trasparan.
 
Kata kunci : Sabun Padat Transparan, daun jambu biji, Formulasi sabun
Evaluasi Fisik dan Uji Kesukaan Sediaan Masker Gel Peel Off Serbuk Cangkang Telur (Pullum Ovum) dan Madu (Apis)
Authors: Zakaria Nurmalia , Fauziah  , Sari Amelia , Zarwinda Irma , Elfariyanti
Published: February 2025

Cangkang telur (Pullum Ovum) dan memiliki kandungan 97% kalsium karbonat, fosfor, magnesium, natrium, kalium, seng, mangan, besi, dan tembaga. Madu merupakan humektan alami dimana madu bisa menarik air dan mempertahankannya di dalam lapisan kulit sehingga terhidrasi dan kenyal. Kombinasi kedua bahan ini diharapkan mampu memberikan efek perawatan pada kulit wajah sebagai anti aging untuk kulit wajah. Penelitian ini bertujuan untuk memformulasikan serbuk cangkang telur dan madu dalam sediaan masker gel peel off dan melakukan evaluasi fisika, uji iritasi dan uji kesukaan panelis. Penelitian bersifat eksperimen yang dilaksanakan di Laboratorium Farmasetika Akafarma Banda Aceh pada tahun 2022. Masker gel peel off dibuat dalam 4 formula dengan variasi konsentrasi serbuk cangkang telur yaitu 1% (F1), 2% (F2), 3% (F3). Basis yang digunakan yaitu Polivinyl Alkohol (PVA) dan Hidroxy Propyl Methyl Cellulosa (HPMC) dan dilakukan evaluasi fisik terhadap sediaan tersebut. Hasil penelitian menunjukkan ketiga formula masker gel peel off memenuhi syarat evaluasi fisika dan uji iritasi. Hasil uji kesukaan menunjukkan bahwa formula yang paling disukai responden dari segi bentuk F1, dari segi warna F1 dan F2, dari segi aroma yaitu F2. Maka disimpulkan bahwa Serbuk cangkang telur dan madu dapat diformulasikan dalam sedian masker gel peel off dengan karakteristik fisik dan hasil uji iritasi yang baik.
Kata kunci : Cangkang telur, Madu, Formulasi, Masker gel peel-off, Evaluasi sediaan
Das Ende rechter Räume - Zu Territorialisierungen der radikalen Rechten
Authors: Terra-R Autor*innenkollektiv
Published: February 2025

Rechtsradikalismus wirkt als gesamtgesellschaftliches Phänomen durch räumliche Praktiken und Diskurse, Symboliken und Affekte. Ebenso haben rechte Mobilisierungen vielfältige räumliche Dimensionen, von Nationalität und Geopolitik über Globalisierung und Migration bis hin zu Stadt-Land-Beziehungen. Doch wie lassen sich diese Dimensionen analysieren und für die politische Opposition zugänglich machen? Um diese Frage zu adressieren, schlägt das Autor*innenkollektiv Terra-R das Konzept der Territorialisierung vor. In elf Kapiteln zeigt es Forschungszugänge sowie praxisbezogene Implikationen auf.
Digital Marketing And Organizational Performance: Case Of Banking Companies In Guinea
Authors: LAWANI Dr Aminou , Yaya CISSÉ Dr Mamady , KPOGHOMOU Dr Makolo
Published: February 2025

In this study, we sought to analyze the impact of digitalization on the performance of banking services in Guinea. The results demonstrate that the more a banking service is digitalized, the more it improves its performance, particularly in terms of service efficiency and increased turnover. As such, we conducted surveys to characterize the digital behaviors of Guinean banks. Digital marketing skills are not very abundant due to the fact that this discipline is recent. Our results also demonstrate that the majority of respondents think that digital is a competitive advantage. The presence and availability of the website leads to visibility. She also believes that this will indirectly increase the bank's turnover. This turnover achieved therefore depends on the presence of digital display in the integrated planning. Most banks with high turnover have a digital display.