bluuebunny/crossref_metadata_2025 huggingface dataset:
Electronic Medical Record application with Artificial Intelligence in supporting the clinical learning of professional doctoral students: findings of a mixed-method approach
Authors: Darsono Kinik , Emilia Ova , Widyandana Doni
Published: December 2024

In this study, we evaluated the benefits of an Electronic Medical Record application with Artificial Intelligence (EMRAI) in supporting the clinical learning of professional doctor students (co-assistants) at Gadjah Mada University. The EMRAI was designed to overcome the limitations of filling in medical records and improve diagnosing accuracy. We used mixed methods in this study: a quasi-experimental design for quantitative analysis and focus group discussions (FGD) for qualitative analysis. The research participants included 60 students divided into experimental (30 students) and control (30 students) groups using the EMRAI and paper medical records, respectively. The results showed that the experimental group had a significantly higher average post-test score than the control group (91.80 vs. 71.42, respectively; P < 0.05). FGDs revealed that EMRAI helps in diagnosis enforcement, critical thinking, and medical documentation and improves the clinical reasoning and professionalism of students. Students provided feedback for the further development of the EMRAI, including improved user interfaces and interactive features. In conclusion, the EMRAI had a positive effect on improving students’ clinical competence; however, it requires additional development to improve functionality and accessibility. Its implementation can help address students’ challenges in completing medical records, enhancing clinical skills, promoting technological learning innovations, and reducing medical errors while improving the quality of healthcare services. Therefore, research recommendations include assessing the effect of the EMRAI on other aspects of clinical learning, involving a more diverse population, and a longer duration of research for long-term observation.
Virus-free meristem culture, calli induction, and regeneration optimization of cultivated and unreleased potatoes of Nepal
Authors: Mishra Kunjan , Rijal Anuja , Shrestha Roshan , Rajbahak Sabari , Joshi Jarina , Pradhan Pragati , Giri Richa , Dangol Sarbesh Das
Published: December 2024

In Nepal in terms of cultivated area, potato ranks as the fourth imperative crop and the first in case of productivity. In such a crucial crop of Nepal, it is inevitable to develop virus-free potatoes and optimize their callus induction and regeneration protocols for further genetic manipulation studies. In this study, we used various plant growth hormones such as gibberellic acid (GA3), kinetin, and 6-benzyl amino purine (BAP) for meristem culture optimization of eleven different cultivated and unreleased Nepali potatoes. The presence of virus in the plantlets was tested using the Double Antibody Sandwiched-Enzyme-Linked Immunosorbent Assay (DAS-ELISA) method. Similarly, internode explants from five different cultivars were used to induce calli using 2,4 diphenoxyacetic acid (2,4-D), kinetin, naphthalene acetic acid (NAA), and BAP, and subsequently regeneration using GA3. We found the best regeneration results from meristem culture using 0.25 mg/L GA3 for cvs. Rosita, Halka Nilo, Purple, Desiree, and unreleased 226. Virus-free plantlets tested for the six viruses common in local potato cultivars of Nepal were observed using the DAS-ELISA method. The combination of BAP and NAA induced the highest calli in cvs. MS42.3, Panauti Local, Purple, and Khumal Upahar. The highest regeneration frequency using 0.25 mg/L GA3 was obtained from the calli incubated for MS42.3 and Panauti Local. We have successfully optimized the meristem, calli induction, and regeneration protocol for the agronomically important crops of Nepal which can further be used in microtuberization, generation of pre-basic seeds, and genome manipulation studies.
PCI-DB: A novel primary tissue immunopeptidome database to guide next-generation peptide-based immunotherapy development
Authors: Lemke Steffen , Dubbelaar Marissa L. , Zimmermann Patrick , Bauer Jens , Nelde Annika , Gravel Naomi Hoenisch , Scheid Jonas , Wacker Marcel , Jung Susanne , Dengler Anna , Maringer Yacine , Rammensee Hans-Georg , Gouttefangeas Cécile , Fillinger Sven , Bilich Tatjana , Heitmann Jonas S. , Nahnsen Sven , Walz Juliane S.
Published: December 2024

Various cancer immunotherapies rely on the T cell-mediated recognition of peptide antigens presented on human leukocyte antigens (HLA). However, the identification and selection of naturally presented peptide targets for the development of personalized as well as off-the-shelf immunotherapy approaches remains challenging. Here, we introduce the open-access Peptides for Cancer Immunotherapy Database (PCI-DB, https://pci-db.org/), a comprehensive resource of immunopeptidome data originating from various malignant and benign primary tissues that provides the research community with a convenient tool to facilitate the identification of peptide targets for immunotherapy development. The PCI-DB includes > 6.6 million HLA class I and > 3.4 million HLA class II peptides from over 40 tissue types and cancer entities analyzed uniformly using high-sensitive nf-core bioinformatics pipelines and applying a global peptide false discovery rate. First application of the database provided insights into the representation of cancer-testis antigens across malignant and benign tissues, enabling the identification and characterization of cross-tumor entity and entity-specific tumor-associated antigens as well as naturally presented neoepitopes from frequent cancer mutations. Further, we used the PCI-DB to design personalized peptide vaccines for two patients suffering from metastatic cancer. In a retrospective analysis, PCI-DB enabled the composition of both a multi-peptide vaccine comprising non-mutated, highly frequent tumor-associated antigens matching the immunopeptidome of the individual patient´s tumor and a neoepitope-based vaccine matching the mutational profile of a cancer patient. Both vaccine approaches induced potent and long-lasting T-cell responses, accompanied by long-term survival of these advanced cancer patients. In conclusion, the PCI-DB provides a highly versatile tool to broaden the understanding of cancer-related antigen presentation and, ultimately, supports the development of novel immunotherapies.
Tumor Microenvironment In Head And Neck Cancer: Insights From Spheroids
Authors: Rao Anshu , Das Uddalak , Ghodeswar Amey , Chaturvedi Rupesh
Published: December 2024

The study of head and neck cancer (HNC) has been significantly enhanced by the development of 3D spheroid models, which closely replicate the in vivo tumor microenvironment (TME) by preserving cellular heterogeneity, hypoxic regions, and tumor-specific cell interactions. Traditional 2D models lack the capacity to capture these critical characteristics, which are essential for understanding tumor biology and therapeutic responses. This review summarizes recent advancements in HNC spheroid research, with a focus on their applications in drug testing, TME simulation, and therapeutic development. We discuss the role of spheroids in modeling key aspects such as drug resistance, hypoxia, cancer stem cell behavior, and epithelial-mesenchymal transition (EMT). Despite challenges, including variability and scalability limitations, 3D models hold significant promise for advancing precision medicine in HNC. We also explore the use of these models in evaluating therapeutic strategies, including chemotherapy, molecular-targeted therapies, and immunotherapy. Furthermore, we conduct a bibliometric analysis to assess research trends and identify emerging topics within the field of HNSCC and 3D tumor modeling. The ability of 3D spheroid models to predict patient-specific responses to treatment is highlighted, underscoring their potential for advancing personalized medicine. By examining key cellular processes that drive tumor progression and therapy resistance, we evaluate how effectively these models replicate tumor biology and speculate on future advancements that could further enhance their relevance in cancer research and treatme
Adapting to Adversity through Resilience: The Role of Integrated Health Services Delivery in Sustaining Routine Health Services During COVID-19
Authors: Hasan Md Zabir , Ahmad Iman , Lee Rachael , Haider Shams Shabab , Gupta Shivam
Published: December 2024

Background
The COVID-19 pandemic challenged health systems in low- and lower-middle-income countries (L-LMICs), emphasizing the need for resilience—the ability to predict, prepare for, absorb, and adapt to external shocks while maintaining essential functions and improving performance. This scoping review examined the application of Integrated Health Service Delivery (IHSD) strategies to sustain routine (non-COVID-19) healthcare services during the pandemic.
Methods
We searched PubMed/MEDLINE, Scopus, EMBASE, Web of Science, CINAHL Plus, Cochrane, and the WHO Global Research on COVID-19 database from 01 January 2020 to 02 December 2022 for peer-reviewed studies written in English, based on a published protocol (doi: 10.1136/bmjopen-2020-042872).
Results
Of the 4,286 records screened, 30 studies were included in the review, encompassing a range of health topics, including systems strengthening (n = 8), noncommunicable diseases (n = 6), specialized care (n = 6), HIV (n = 3), mental health (n = 3), and other services (n = 3), highlighting the versatility of IHSD models during the pandemic. The results showed a dynamic blend of four typologies of IHSD – organizational (n = 15), functional (n = 17), service (n = 27), and clinical integration (n = 15) – each contributing significantly to the resilience of health systems. Organizational integration facilitated effective coordination and multisectoral collaboration; functional integration emphasized building workforce capacity and digital infrastructure; service integration adapted care delivery through community outreach and telehealth; and clinical integration supported the adoption of new care protocols.
Conclusion
This review offers critical insights into the application of integrated care approaches, demonstrating their potential to enhance system resilience and inform future health system strengthening efforts in L-LMICs amid ongoing and future healthcare challenges.
Effect of colored traps and sex pheromone on the capture of Spodoptera frugiperda
Authors: Brandão Janethe Machado , Magalhães Vinícius Silva , Barbosa Cejana Rayssa de Jesus , Solá Filipe Augusto , Rosa Maria Eduarda Monteiro , Godinho Karina Cordeiro Albernaz , Czepak Cecilia
Published: December 2024

Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae), stands out as one of the main pests threatening the productivity of the corn crop (Zea mays L.). The search for new control strategies has proved important given that the use of insecticides predominates. A sustainable alternative is the use of sex pheromone traps to monitor and manage pests. These traps help identify the most appropriate time to implement control measures, minimizing dependence on insecticides. Research into the color preferences of insects can improve the effectiveness of these traps. The experiment was conducted in four different regions of Goiás, namely: Silvânia, Pontalina, Vianópolis and Palminópolis, using a randomized block design with five treatments and four replications, for each target pest. The treatments consisted of Delta-type traps in five colors: white, yellow, red, blue and black, and synthetic S. frugiperda sex pheromones were placed in all the traps. Each week, the glue bases were quantified in terms of the number of specimens captured and replaced with a new base. In the case of the pheromones, they were changed every 21 days. The count data was analyzed using generalized linear models, using the Poisson distribution. The red color was more attractive to S. frugiperda, while the white color was more attractive to predatory insects.
Avaliação Clínica e Funcional de Fraturas do Rádio Distal tratadas com Placa de Distração Dorsal.
Authors: Santos Ianara da Silva , Sessa da Silva Jéssica Colamarino , Fonseca de Sá Bruno Gomes , Rodrigues Leonardo Moscardini Pimenta , Serrano Sara Dadona Correia , Souto Cícero José Silva , Rezende Luis Guilherme Rosifini Alves
Published: December 2024

Introdução: As fraturas mais comuns nos membros superiores são as fraturas da extremidade distal do rádio. Com acometimento bimodal, são ocasionadas por traumas de baixa energia em pacientes idosos e alta energia em pacientes jovens. Nos casos com acometimento articular e cominuição distal, a escolha do implante no tratamento cirúrgico torna-se um desafio para médicos ortopedistas e cirurgiões de mão. Diante disso, a placa de distração dorsal tem sido utilizada como uma opção com bons resultados funcionais nesse tipo de patologia. Métodos: Estudo retrospectivo, realizado em um hospital terciário por meio de revisão de prontuários de 2020 a 2024 de pacientes com fratura do rádio distal AO/OTA 2R3C3 tratados com placa de distração dorsal do tipo LCP 3,5mm. Resultados: Houve prevalência de pacientes do sexo masculino, com predominância do trauma de alta energia, sendo o acidente de trânsito responsável por 80% dos casos. Os pacientes foram avaliados após a retirada do implante pelo escore de Quick-Dash, Escala Visual Analógica de Dor (EVA) e Patient Rated Wrist Evaluation (PRWE), apresentando resultados satisfatórios. Conclusão: Diante da dificuldade encontrada no tratamento de fraturas complexas da extremidade distal do rádio, a placa de distração apresenta-se como uma boa opção no tratamento cirúrgico desta patologia ortopédica.
تمليك أراضي الدولة للمتجاوِز عليها – دراسة تحليلية
Authors: مجيد قادر ظاهر , إبراهيم الحيدري هيوا
Published: December 2024

منح المشرع الكوردستاني، بموجب أحكام قانون تمليك الأراضي المتجاوز عليها ضمن حدود البلديات في إقليم كوردستان – العراق رقم (3) لسنة 2019 المعدل، للشخص المتجاوز حق تملك الأرض المتجاوز عليها، وبذلك لم يأخذ المشرع الكوردستاني الحماية الدستورية للمال العام بنظر الاعتبار، كما تجاوز بذلك الثوابت التشريعية التي تقر المسؤولية الجزائية والمسؤولية المدنية للمتجاوز على أراضي الدولة بما يفضي إلى مساءلته عن عمله غير المشروع، بيد أن المشرع الكوردستاني بدلاً من ذلك، كافأ المتجاوز بمنحه حق التملك، لذا تسلط هذه الدراسة الضوء على أحكام القانون المذكور ومدى مشروعيته من الناحية الدستورية ومدى تعارضه مع الثوابت التشريعية، فضلاً عن تقييم مدى نجاعة هذا الأسلوب والسياسة التشريعية في معالجة ظاهرة التجاوز على أراضي الدولة.
WHISTLE-BLOWERS- LET THE LID BLOW OFF
Authors: Singh Sodhi Jasjit
Published: December 2024

Most of the time, whistleblowing is looked at from the point of view of professional ethics. The idea of freedom and the needs of professionals are seen as immoral by morality. But because people who speak the truth are often punished horribly, morality needs to leave a way out of blowing the whistle. This is why it creates rights (which are sometimes called duties) to take precedence over the duty to the public set by professional rules. Its not a matter of duty to blow the whistle, but this makes it look like it is while hiding the truth. Remember that blowing the whistle was either the right thing to do, which no one wants to do. People still judge it based on why the person who blew the whistle did. In a way, people who blow the whistle should try to be good. But it doesnt make sense to say that spies are heroes or saints and that they have to blow the whistle. Thats not what morals is all about. It makes the good deeds of a few people seem more important than the lives of many. But being consistent isnt a big part of being decent at work.
Enhancing the perception of a student-friendly institution through the green environment: Insights from a Hungarian university
Authors: Horváth-Csikós Gabriella , Juhász Tímea
Published: December 2024

This paper explores the concept of place attachment, encompassing its meaning and representation among university students. It provides a comprehensive picture of place identity and place attachment among university students. The planned approach was to conduct a survey among students to examine their attachment to place from a green perspective. A questionnaire was used, and the data were analyzed using SPSS version 28 and Smart PLS 4. This paper summarizes the results of a survey of 245 students studying at the Budapest University of Economics and Business in 2022/23. The students were graduates in International Studies and Commerce-Marketing. The setting of the study was the university environment because it is an institution of higher education, a bastion of knowledge transfer, and the issue of attachment is very important in the relationship between educational institutions and students. The results confirmed that students perceived green energy (β: 0.283, t: 4.637 p: 0.000) and green solutions (β: 0.430, t: 9.155 p: 0.000) as having a significant effect on whether or not they perceived the institution as student-friendly. It is no coincidence, therefore, that students are satisfied with the green environment of the university (74%). They believe that the university has an adequate amount of green space (68%). However, the current situation could be improved, with a large proportion of students missing the widespread use of green (79%) and renewable energy (70%) in the institution.
¿Es mi profesión vocacional? Aportes de la psicología para comprender la relación entre la profesión y la identidad
Authors: Villacís Jorge L.
Published: December 2024

Este artículo busca responder a la pregunta de qué es una profesión vocacional, o más concretamente, a qué se refiere la psicología cuando aplica el adjetivo “vocacional” al proceso de elegir una profesión. En primer lugar, se hará una exposición breve de las principales teorías en psicología sobre la identidad y la elección de carrera. En dichas teorías el término “vocacional” denota un ajuste entre la persona (los intereses y habilidades individuales) y el entorno (el ambiente de trabajo y las aptitudes requeridas en este). En segundo lugar, se mostrará que un aspecto poco estudiado en las teorías de elección y desarrollo de carrera es el aspecto moral. Esto se entiende como la motivación a ejercer la profesión con una orientación prosocial (cuidar-atender a las personas). Este artículo sugiere que la relación entre el ajuste vocacional y la motivación moral en el ejercicio profesional ofrece interesantes posibilidades a la investigación empírica.
Case report of 2-year-old child with congenital torticollis and crossbite treated with functional orthopedics of the jaws
Authors: Bittar Karina Correia Bonalumi
Published: December 2024

Satisfactory chewing is performed by an alternating bilateral pattern that depends on occlusal balance, the absence of occlusal interference or premature contacts, stability, good functioning of the temporomandibular joints (TMJs) and neuromuscular maturation. If mandibular functional imbalances occur, discrepancies in maxillomandibular development and future facial asymmetries may occur. The objective of this work was to remove dental interferences that cause anterior and posterior crossbite, as well as those that prevent the good execution of symmetrical lateroprotrusive movements (right side/left side), through occlusal adjustment and subsequent correction of maxillary asymmetry using the device; encapsulated. Clinical case report of a two-year-old female patient, with unilateral crossbite on the right side (anterior/posterior), diagnosed with congenital torticollis, difficulty breastfeeding and difficulty performing alternating lateral movements. with follow-up until the complete deciduous dentition. The treatment was divided into three stages. The first step was to correct the unilateral crossbite (anterior and posterior), on the right side, by making occlusal adjustment using a grid, and later with the addition of Planas Direct Tracks resin. The second stage used an encapsulated device to correct maxillary asymmetry. The third stage was completed after the eruption of the deciduous second molars with the functional analysis of lateral movements plus occlusal adjustments using a grid. Correction of unilateral crossbite (anterior and posterior) on the right side, symmetrization of the maxilla and better execution of lateroprotrusive movements. The results obtained in this case report suggest that the occlusal adjustment removed the dental interferences that caused the anterior/posterior crossbite on the right side; the maxilla was symmetrized with the distalization of sector 63-65, and the removal of dental interferences that prevented lateral movements made it possible to perform lateroprotrusive movements (right/left side) after the complete eruption of the primary teeth.
Oktay Arayıcı Oyunlarının Epik Diyalektik Tiyatroyla “İlişkisizliği”
Authors: Erol Şeref
Published: December 2024

Bu çalışmada, Oktay Arayıcı’nın eserlerinin Bertolt Brecht’in epik-diyalektik tiyatro kuramıyla ilişkilendirilme iddiaları incelendi. Arayıcı’nın tiyatro oyunlarıyla, Brecht’in epik-diyalektik tiyatrosunda olduğu savlanan ilişkililiğin geçerli nedenlerinin olmadığının gösterilmesi, Arayıcı’nın tiyatro anlayışının özgünlüğü ve Geleneksel Türk Tiyatrosu ile olan ilişkisinin vurgulanması amaçlandı. Araştırmanın hipotezi olarak, Arayıcı’nın oyunlarıyla, Brecht’in tiyatro anlayışı arasında doğrudan bir bağlantının kurulamayacağı savlandı. Buna karşın Arayıcı’nın, Geleneksel Türk Tiyatrosu’nun göstermeci biçimi kullandığı öne sürüldü. Bu hipotez doğrultusunda, araştırmanın nesnesi olarak, Arayıcı’nın ve Brecht’in probleme uygun oyunları seçildi. Arayıcı’nın oyunları, Brecht’in kuramsal metinleri ve tiyatro anlayışıyla karşılaştırmalı olarak incelendi; karakterlerin psikolojik derinliği, olay örgülerinin yapısı ve dramaturjik özellikler analiz edildi. Arayıcı’nın oyunlarının Geleneksel Türk Tiyatrosu ilkelerine, Brecht’in ise modern tiyatro dili olan epik-diyalektik tiyatro ilkelerine ait olduğu, tiyatronun yapısal unsurlarıyla ilişkilendirilerek, açığa çıkarılması hedeflendi. Bu iki tiyatro örneğinin yapısal uygunlukları ve uygunsuzlukları, oyun metinleri ve oyunların sahnelenmeleri incelendi. İnceleme, ilgili kaynak metinler aracılığıyla, karşılaştırmalı eleştirel yöntemle çözümlenerek belirli hale getirilmeye çalışıldı.
Analysis of Algorithms of Numerical Implementations for the Wonham Filter Under Uncertainty in Measurements Noise Covariance
Authors:   Institute of Informatics Problems, Federal Research Center В«Computer Science and ControlВ» of the Russian Academy of Sciences, Bosov Alexey Vyacheslavovich , Kudryavtseva Irina Anatol'evna ,   Moscow Aviation Institute (national research university)
Published: December 2024

The paper addresses the filtering a continuous-time Markov chain states that can be observed through linear measurements perturbed by a Wiener process. There is supposed the presence of uncertainty in the intensity of measurements noises. The problem is worked out under the assumption of unknown intensity but subject to its known upper bound. If there is no uncertainty in measurements the optimal solution is provided by the Wonham filter that doesn't ensure stable numerical implementations. The paper exposes that the Wonham filter shows robustness in the presence of uncertainty if model's parameters don't imply its divergent. It is detected that to cope with divergence tracking and handling trajectories aren't sufficient in the case of uncertainty. The more efficient way is to consider discretized approximations of the Wonham filter implemented for a discrete model that approximates the initial continuous-time measurements system. Such an approach perceptibly advantages if numerical implementations contain divergent trajectories. If there are no divergent trajectories, then the discretized filters give a slightly worse result but acceptable.
Health and mental health services in Gaza: A system under siege
Authors: Farajallah Iman
Published: December 2024

Gaza’s health care and mental health systems have faced long-standing challenges due to years of political instability, continuous Israeli military wars, and a crippling blockade that has been in place since 2007. These factors have severely hindered Gaza’s ability to provide primary health care, resulting in a system that struggles to meet the needs of its population. Even before October 7th, 2023, Gaza’s healthcare infrastructure was on the brink of collapse, and mental health services were unable to meet the growing needs of the population. The October 3rd, 2023, Israel’s war in the Gaza Strip with its ‘systematic violations of human rights’ has led to the catastrophic deterioration of Gaza’s health infrastructure to date. This Israeli war with its ‘systematic violations of human rights’, marked by intense Israeli military operations and massive destruction, pushed an already fragile healthcare system into a severe crisis. This paper examines the state of healthcare and mental health services in Gaza. It evaluates the impact of the continued Israeli offensives in the Gaza Strip, particularly during the 2023-2024 Israeli war with ‘systematic violations of human rights’.
Efeito de diferentes diluidores na conservação do sêmen de zangões de abelhas Apis mellifera africanizadas (Hymenoptera: Apidae)
Authors:   , Morais Lucas da Silva
Published: December 2024

É sabido que o conhecimento acerca da biologia e importância das abelhas para o homem e para o
mundo esteja em expansão, entretanto ainda são escassas as informações acerca da fisiologia
reprodutiva dos zangões, bem como sobre ferramentas para conservarção do seu sêmen,
principalmente com as abelhas africanizadas. Com isso, estabelecer um protocolo de refrigeração
e criopreservação de espermatozoides de zangões de abelhas africanizadas (Apis mellifera) foi o
objetivo desse trabalho. Para tanto, o estudo foi dividido em dois experimentos, os quais
utilizaram-se zangões adultos de abelhas africanizadas oriundos do Núcleo de Capacitação
Tecnológica em Apicultura – NCTA. O primeiro experimento descrito no capítulo I, traz
informações sobre efeito de diferentes diluentes na preservação de sêmen refrigerado de abelhas
africanizadas (Apis mellifera) a temperatura de t 16 ± 1ºC, sob os parâmetros espermáticos de pH,
motilidade, viabilidade, HOST e morfologia. Para tanto, os diluentes utilizados foram o Tris, Tris
+ EY, Collins e Ringer. As amostras foram refrigeradas em incubadora de demanda biológica de
oxigênio à 16 ± 1ºC durante um período máximo de 96 horas. Já o segundo experimento descrito
no capítulo II, traz informações sobre o efeito de diferentes diluentes na criopreservação do sêmen
abelhas africanizadas (Apis mellifera), sob os parâmetros espermáticos de motilidade, viabilidade,
HOST e morfologia. Sendo os diluentes Tris, Tris + EY e Collins utilizado nesse experimento.
Para a criopreservação, as amostras foram refrigeradas a 15ºC por 40 min em caixas isotérmicas e
estabilizadas a 5ºC por 10 min em incubadora biológica. Em seguida foram colocadas em contato
com o vapor de nitrogênio por 10 minutos e finalmente armazenadas em um recipiente
criobiológico a -196ºC. Após 1 semana, as palhetas foram descongeladas individualmente em
banho-maria a 37ºC por 30 segundos. Nos dois experimentos as amostras foram diluídas na
proporção de diluição 12:1 (diluente: sêmen). Os parâmetros espermáticos sofreram alterações
significativas após o processo de refriegeração e criopreservação. Estes estudos foram pioneiros a
que se refere, na utilização de diferentes diluentes, com o propósito de desenvolver um diluente
comercial para conservação do sêmen de zangões de abelhas
Uso de acidificante para otimização da adubação fosfatada em solo de reação alcalina na cultura da melancia irrigada
Authors:   , Silva Max Venicius Teixeira da
Published: December 2024

No Rio Grande do Norte, a melancia tem tido grande importância em função das

características edafoclimáticas e do propício mercado consumidor, onde a mesma

deixou de ser uma cultura explorada apenas no período das chuvas, com a desígnio de

abastecer mercados locais, para se tornar uma atividade tecnificada de produção

destinada tanto ao mercado interno como externo. A pesquisa foi realizada em duas

épocas, setembro a novembro de 2017, e agosto a outubro de 2018, na fazenda Roçado

Grande, Upanema-RN. O trabalho teve como objetivo avaliar aplicação do enxofre

elementar associado a adubação fosfatada em um cambissolo com e sem histórico

cultivo irrigado na cultura da melancia na região de Mossoró-RN. O delineamento

Adotado foi em blocos casualizados em um esquema fatorial de 4x3. No primeiro

experimento, utilizando a cultivar Magnum, os tratamentos foram constituídos de 4

doses de fosforo (0, 30, 60, 90 kg ha-1 de P2O5) e 3 doses de enxofre (0, 250 e 500 kg ha-

1 de S), já no segundo experimento com a cultivar Quetzali, foram aplicadas 4 doses de

fósforo (0, 30, 70 e 110 kg há-1 de P2O5) e 3 de enxofre (0, 250 e 500 kg ha-1 de S). A

melancia Magnum obteve produtividade comercial máxima nas doses de 60,7 kg ha-1 de

P2O5 no solo sem histórico de cultivo, e 62,5 kg ha-1 de P2O5 no solo com histórico de

cultivo, sendo que a partir dessa dose houve redução dos valores. Em relação a

produtividade total, os maiores valores foram observados nas doses intermediarias de

fósforo (30 e 60 kg ha-1 de P2O5) combinado com as menores doses de enxofre (0 e 250

kg ha-1 de S). As doses de fósforo influenciaram estatisticamente todas as variáveis de

qualidade de frutos, exceto, pH da polpa, embora todos os frutos obtiveram as faixas

ideias de aceitação do mercado consumidor. As doses de fósforo influenciaram

produtividade comercial da cultivar quetzali, com as plantas de melancia obtendo

valores máximos variando de 45 a 53 t ha-1 no solo com e sem histórico de cultivo

irrigado. A aplicação de enxofre não influenciou a produtividade total da cultivar

quetzali, pois os maiores valores foram vistos na dose de 0 kg ha-1 de S. As variáveis de

qualidade de frutos foram influenciados pelos tratamentos, com exceção, a pH da polpa,

entretanto, os valores observados nas análises ficaram faixa de aceitação do mercado
Photoresponsive Nanoparticles for One Health
Authors: Leonard Estelle
Published: December 2024

Photoresponsive nanoparticles (NPs) have emerged as innovative tools within the "One Health" framework, addressing interconnected health issues spanning humans, animals, and the environment. "One Health" represents an integrative approach that underscores the interdependence of human, animal, and environmental health, tackling challenges such as zoonoses, food safety, and antimicrobial resistance. This study explores the role of photoresponsive NPs, focusing on photochromic and photothermal NPs, in advancing applications relevant to One Health. We describe the synthesis and functional characteristics of photochromic and photothermal NPs, emphasizing their responsiveness to light as a means of controlled action. Photoresponsive NPs such as zinc oxide, magnesium oxide, and titanium dioxide exhibit significant activity against phytopathogens, providing sustainable solutions to agricultural health threats and reducing reliance on chemical pesticides. Furthermore, the study details advancements in photoresponsive NPs for human health applications, including their utility in targeted drug delivery and release, cancer phototherapy, diagnostic imaging, biosensing, and wound healing. These applications showcase the potential of photoresponsive NPs to enhance treatment precision and efficacy while minimizing side effects.
Investigation of the vibrational characteristics of tzouras 3D printed top plates
Authors: BREZAS Spyros
Published: December 2024

Abstract. This work describes an integrated method for the investigation of the vibrational characteristics of 3D printed tzouras top plates. The top plates vary in thickness, in tandem to the dimensions of a wooden instrument. The frequency response of the manufactured top plates is determined by modal measurements and the vibration modes are visualized using holographic imaging and further compared to finite element simulation results. The measurements reveal insights applicable to the manufacturing of the instrument by alternative and modern materials. Further analysis includes measuring the vibrational characteristics of a functional wooden tzouras. To gradually implement the transition from traditional to alternative materials, the detached wooden top plate of the instrument is also studied. A correlation criterion is used to compare the responses of the traditional instrument and the top plates for improving their vibroacoustic performance.
Vibration signal and roughness correlation during Ti alloy milling using uncoated and coated Ti-based cutting tools
Authors: SALES-CONTINI RCM
Published: December 2024

Abstract. This work evaluates the coated and uncoated (4 flutes) tools´ performance in the milling of Ti-6Al-4V alloys in a lubricated environment using three different cutting speeds and two different feed rates. This was planned because there is no conclusive analysis in the literature between the variation of the vibration signal, the quality of the milled surface and the tool performance. Concerning tool wear, the vibration analyses were correlated with surface roughness and optical microscopy results.
Design of a device for cold plastic deformation processing using the ideas diagram method
Authors: BOCA Mihai
Published: December 2024

Abstract. Among all the cutting processes, the turning process is the most widely spread process currently used in industry. Together with the machine tool, using the movements performed during work piece machining, the process could be adapted to achieve other processes techniques. An example of innovation has been proposed in this study. The authors emphasize a new perspective of using a lathe machine tool by its cutting tool, which after being used in the turning process can be used as a tool for performing a plastic deformation process. This fact will contribute to an increase in the hardness of the processed surface. The device obtained by using the ideas diagram method will enable its use to perform cold plastic deformation with the same cutting tool used in the turning process. The results, materialized by the obtained device, will allow the performance of all necessary movements to ensure the conditions that allow the implementation of the process and to obtain an increase of the surface hardness for a cylindrical work piece initially subjected to a turning process.
Effect of orientation on the bending properties of a carbon fibre reinforced thermoplastic
Authors: MONKOVA Katarina
Published: December 2024

Abstract. Additive manufacturing is becoming a very rapidly developing production technology. It provides a wide range of combinations of material processing and used techniques, including the possibility of using different types of 3D printing machines. In order to know the properties of the part and take them into account in the design of the product, it is necessary to know the behaviour of the sample after loading, which was produced under the given specific conditions. The manuscript aims to study the bending characteristics of samples made of plastic reinforced with carbon fibres using additive technology. The samples of the same type were fabricated by FDM (Fused Deposition Modelling) using a MakerBot Method X printer. The experimental investigation was carried out using a Zwick 1456 testing machine. The experimentally tested samples were oriented in two different ways regarding the layers building. The measured data were evaluated and compared with the numerically obtained values. The results showed a strong effect of the sample orientation on the bending properties.
Shape parameter optimisation of elliptic tool paths in trochoidal slot milling
Authors: JACSO Adam
Published: December 2024

Abstract. Trochoidal milling is a highly effective machining strategy for hard-to-reach areas like corners and slots. This strategy was initially developed using circular arc and cycloid-based tool paths. Recently, elliptic trochoidal tool path patterns have emerged as an even more efficient alternative. However, this advancement raises new questions as the analytical functions previously used to describe the cutter engagement will no longer be valid along the elliptic path. Additionally, changing the ellipse aspect ratio can completely alter the nature of tool load development. While there are examples of tool load modelling for the elliptic trochoidal strategy in scientific literature, there is still a need to directly connect these methods with productivity aspects. This study introduces a newly developed optimisation method that achieves two goals: (1) specifying the maximum permissible trochoidal step for a desired cutter engagement limit and (2) determining the optimal ellipse aspect ratio to achieve maximum material removal rate while respecting the boundary conditions. The presented optimisation method was validated by both experimental and simulation results. Although this algorithm is currently only applicable to trochoidal machining of straight slots, it has the potential to be extended to general shapes in the future.
Enhancing vocational education through digital training materials: A case study on CNC lathe training
Authors: BILGIN Musa
Published: December 2024

Abstract. This study investigates the effect of virtual reality (VR)-based and interactive training materials on practical and academic achievements in computer numerical control (CNC) lathe training. To this end, VR and interactive training materials were developed for tasks involving cutting tool measurement and defining a workpiece zero-point. Sixteen students, all without prior VR or CNC lathe experience, were divided into experimental and control groups. Participants were subjected to traditional and digital-based training methods, and their practical and academic performances were subsequently analyzed. The findings revealed that VR-based digital training materials significantly enhanced students' success and reduced the training time in CNC lathe training. Furthermore, the accessibility of materials at students' convenience through interactive educational content reduces educational costs, facilitates learning processes, and contributes to environmental sustainability.
ANOVA and correlation analysis of feed, cutting forces and tool vibration in 11SMn30 steel turning
Authors: FELHŐ Csaba
Published: December 2024

Abstract. The shift towards industry 4.0 in automative parts manufacturing and cloud machining solutions requires an understanding of materials machinability. To manufacture high quality products feed, cutting forces and tool vibration are important machining parameters that their dependence on one another other needs to be identified. This paper studies the Pearson correlation between feed, cutting forces and tool vibration and ANOVA is calculated to verify the validity of model. 11SMn30 a widely used steel grade for manufacturing shafts was used in the current study because of its very good machinability. The results suggests that feed rate influences both cutting forces as well as vibration in tool which has an overall effect on product quality.
Laser machining with a high-power CW fiber laser
Authors: GOSTA Alexandros
Published: December 2024

Abstract. We investigate the CW fiber laser - aluminum 1050 alloy interactions. The manufacturing processes of laser marking, engraving, and cutting are studied by experiments and numerical simulations. The laser head Precitec LightCutter 2.0 motorized 3D is mounted on a 3-Axis CNC milling machine, assembled with the Pipa-Q connector and the powerful CW 2kW Trumpf fiber optic laser. The fiber laser beam interacts with the aluminum samples for varying laser flux and laser scanning speeds. The temperature distribution is monitored by a thermal camera, while thermocouples are used to measure the temperature at specific locations on the sample. A white light interferometric technique is applied for measuring the marking and engraving depths of the irradiated samples. A thermostructural finite element method model, accounting for elastoplastic effects and phase changes, is developed to simulate the laser machining processes, providing key insights into the thermomechanical behavior. A satisfactory agreement between experiments and simulations demonstrates the great potential of high-power fiber lasers in manufacturing.
Methodology for identifying the intersection of mutually intersecting surfaces to optimize sheet material cutting for the fabrication of parts and structures
Authors: TSONEVA Zoya
Published: December 2024

Abstract. Sheet material is often used to create intricate details and complete structures in engineering, essential in both industry production and building construction. It is common to design and construct structures that involve various intersecting basic geometric surfaces. Introduced in the present paper is a validated methodology for identifying the intersection of two or more mutually intersecting surfaces. Utilizing the developed methodology can greatly simplify the production of complex surface details and structures from sheet material, leading to improved accuracy in cutting maps, reduced waste generation, simplified work processes, and minimized errors in planning.
Experimental insights into PEG based new fluids thermal effusivity
Authors: COJOCARIU Nicoleta
Published: December 2024

Abstract. Fluids thermal transfer is of utmost relevance in a large number of industrial or semi industrial applications. On the other hand, the need for environmental friendly new fluids plays a relevant role in the heat transfer agent selection. Poly(ethylene glycol) are synthetic, hydrophilic, biocompatible polymers with extensive use in a large number of applications. PEGs are synthesized by means of a ring-opening polymerization of ethylene oxide and a large range of molecular weights and polydispersity’s are produced. From these products, only substances with lower molecular weights can be employed for thermal transfer., more exactly for molecular weight lower than 600. This paper presents the outcomes of an experimental investigation into the thermal effusivity of PEG 400, PEG 200 and water mixtures for convection heat transfer applications. Quite a lot of samples with different concentrations were manufactured, examined and the data were thoroughly discussed comparatively and in the context of cutting-edge advancements. The concept now known as thermal effusivity has been emplyed since the early stages of heat transfer research as a valuable feature for analyzing 1D heat transfer setups.
Investigation of the wear resistance of surface layered by MMA and carbonitriding layers on structural alloy steel
Authors: UCHERDZHIEV Apostol
Published: December 2024

Abstract. This study investigates the wear resistance of surfaces layered by MMA welding followed by carbonitriding, deposited on a 40X structural alloy steel. The primary objective is to develop a technology for restoring worn surfaces of shafts operating in marine environments. Wear resistance was evaluated using a "block-on-ring" test. The microstructure and properties of the obtained layers were analyzed using standard metallographic techniques, including macro and microstructural analysis and microhardness testing. The results of this study will serve as a basis for developing an effective repair technology for shafts used in marine equipment.
Wear resistance of surface layers with subsequent diamond burnishing applied to 40X steel
Authors: MINCHEVA Desislava
Published: December 2024

Abstract. The subject of this study is weld overlays applied with the OK83.28 electrode on 40X steel, which underwent additional hardening through diamond burnishing with a specially designed diamond-tipped tool. The wear resistance of the welded and hardened layers was investigated under dry friction conditions. The wear characteristics of the samples were determined by measuring weight loss. A metallographic analysis of the structure formed in the welded layers after diamond burnishing was conducted. A residual stress analysis in the hardened zone was performed using X-ray diffraction. The microhardness of the hardened layers was measured using the Vickers method with a 50g load.
Sustainability considerations in project management of new product development: Case study
Authors: NICOLAU Mihaela
Published: December 2024

Abstract. Due to an increased concern about global environmental changes, a product made of reusable environmentally friendly materials and processes can be seen valuable to the end user. Many companies use suppliers to design and manufacture sustainable components with certain technical, social, environmental, and economic constraints. The paper proposes a decision framework considering these constraints for ranking sustainable supplier alternatives. A multi-criteria decision-making (MCDM) technique such as Analytic Hierarchy Process (AHP) will be used to determine the weights of the evaluation criteria, and the Technique for Order Performance by Similarity to Ideal Solution (TOPSIS) will be used to rank the alternatives. The results confirm the usefulness of the proposed model in evaluating sustainable supplier selection strategies.
Studying the ergonomics of office furniture with specific art elements and office equipment
Authors: ZLATEVA Ralitsa
Published: December 2024

Abstract. The quality of office furniture in today's computerized work environment significantly impacts workers' health and productivity. This study focuses on the production of ergonomic office furniture that incorporates artistic elements, balancing functionality with aesthetics. The aim is to analyze and evaluate these furnishings, explore their effects, and offer recommendations for enhancing design and functionality. The tasks include a literature review, identifying key characteristics and criteria for ergonomics and aesthetics of art-integrated furniture, analyzing current office furniture and equipment, and investigating the influence of ergonomic designs. Additionally, successful projects and manufacturing practices in Bulgaria and abroad will be examined to optimize the design and production of ergonomic furniture with artistic elements.
Analysis of the efficiency of pneumatic actuator regulation in selected production processes using artificial intelligence, graph algorithms, and probabilistic methods, taking into account failure rates and return on investment costs
Authors: SKUDLIK Piotr
Published: December 2024

Abstract. Modern production systems are characterized by a high degree of automation, where pneumatic actuators play a key role in assembly and transport processes. This paper presents an analysis of the performance of pneumatic actuator regulation using artificial intelligence (AI) algorithms and probabilistic methods in simulated production conditions. The study utilized LSTM neural networks for failure prediction, graph algorithms like Bayesian networks, and Monte Carlo simulations to assess the risk of downtime. The results show that AI models enable a significant reduction in unplanned downtimes and optimization of operational costs through dynamic regulation of actuator parameters. The simulation, based on real operational data, demonstrated that AI models outperform traditional control methods, such as PID controllers, in terms of efficiency and accuracy in failure prediction. However, the applied models have limitations, including high computational requirements and dependence on the quality of input data. The findings suggest that integrating AI algorithms into industrial automation systems can substantially improve production efficiency by reducing operational costs and failure risks. This study highlights the potential benefits of widespread AI adoption in industrial automation, particularly in ensuring long-term system reliability.