bluuebunny/crossref_metadata_2025 huggingface dataset:
Individual Competencies for Self-Managing Team Performance: A Systematic Literature Review
Authors: Doblinger Maria
Published: August 2021

Self-managing teams are popular but they can only benefit team performance if their members are competent to navigate within self-managing systems. Based on a systematic literature search on self-managing, self-directing, and self-leading teams, we reviewed 84 studies related to KSAOs and traits in self-managing teams. Grounded on existing models of team effectiveness and individual KSAOs, we integrated all findings into one KSAO model and showed the relations of single KSAOs with team performance. The results resembled other KSAO frameworks but were more comprehensive and provided practical application and future research guidance, for example, studying team compositions of individual KSAOs.
Diagnosis Disclosure Preferences of Cancer Patients in Egypt: A Multi-Institutional Cross-Sectional Study
Authors: Abdel-hafeez Ahmed , Abdel-Aziz Hadeer I. , Hassan Ahmad , Farag Dina E. , El-Sherief Wessam A. , Abdel-Aal Hesham H. , Alsirafy Samy A.
Published: August 2021

Background:

Although diagnosis disclosure to cancer patients has important roles in cancer care, it is not a routine practice in countries like Egypt. Respecting patients’ autonomy and responding to their preferences are among the factors that should guide the practice of cancer diagnosis disclosure.

Objectives:

To assess the preferences of Egyptian cancer patients regarding the disclosure of cancer diagnosis and to determine factors that may affect their preferences.

Methods:

The study included 295 patients aware of their cancer diagnosis from 3 cancer care facilities in Egypt. Patients were asked if they would have preferred to be informed of the diagnosis or not, whom they would have preferred to receive the diagnosis information from, and if they would have preferred to tell their families or not.

Results:

The vast majority (91%) of the included patients preferred to be informed about their diagnosis, 59% preferred to disclose the diagnosis to their families and 66% preferred to receive the diagnosis information from a physician. In univariate analysis, male gender, higher education level and employment were significantly associated with the preference for disclosure. None of the studied variables associated significantly with the preferences in multivariate analysis.

Conclusion:

The majority of Egyptian cancer patients in our study preferred to be informed about their diagnosis, which should be respected. The results may help in changing the diagnosis disclosure practice of health care professionals and refuting the misconception of family caregivers about cancer diagnosis disclosure in Egypt and countries with similar culture.
Critical Evaluation Capital (CEC): A New Tool for Applying Critical Race Theory to the Evaluand
Authors: Ginsberg Alice E.
Published: August 2021

This article presents a new tool called Critical Evaluation Capital (CEC) designed to address issues of equity and social justice in program evaluation. CEC is grounded in the tenants of critical race theory and inspired by Yosso’s work on community cultural wealth which raises critical issues of positionality and access. CEC is a system for identifying, quantifying, and disrupting the impact of different kinds of power and privilege (named here as capital) that influence the evaluation process and may distort its findings and/or alter its impact. CEC is not meant to be an entirely new evaluation framework or approach, but rather it is designed to be used as a “tool” in conjunction with other contemporary evaluation methodologies, specifically those that reposition the role of the evaluator from an “objective” outsider to an engaged stakeholder. I introduce and describe herein seven foundational categories of CEC, including framing capital, identity capital, connectivity capital, inquiry capital, risk capital, symbolic capital, and dissemination capital, along with a series of accompanying critical questions to guide reflective practice for each capital. I also describe how CEC can be applied across the evaluand—both proactively and retrospectively. I conclude with some key opportunities and challenges CEC presents for evaluators and other key stakeholder groups in the evaluand.
When Technologies are Not Enough: The Challenges of Digital Interventions to Address Loneliness in Later Life
Authors: Barbosa Neves Barbara , Waycott Jenny , Maddox Alexia
Published: August 2021

This article discusses sociotechnical challenges of technology-based interventions to address loneliness in later life. We bring together participatory and multidisciplinary research conducted in Canada and Australia to explore the limits of digital technologies to help tackle loneliness among frail older people (aged 65+). Drawing on three case studies, we focus on instances when technology-based interventions, such as communication apps, were limiting or failed, seeming to enhance rather than lessen loneliness. We also unpack instances where the technologies being considered did not match participants’ social needs and expectations, preventing adoption, use, and the intended outcomes. To better grasp the negative unintended consequences of these technological interventions, we combine a relational sociological approach to loneliness with the Strong Structuration Theory developed by sociologist Rob Stones. This combined lens highlights the connection between sociotechnical factors and their agentic and structural contexts, facilitating a rich understanding of why and when technologies fail and limit.
Simulation of COVID-19 indoor emissions from coughing and breathing with air conditioning and mask protection effects
Authors: Cravero Carlo , Marsano Davide
Published: August 2021

The COVID-19 infection has emerged as a disruptive pandemic at worldwide level. The study of the mechanism of contagion is one of the greatest challenges before a mass vaccination campaign that would protect populations. The study can support the development of knowledge and tools to develop possible strategies for containing its spread in future events. The saliva droplet aerosol expelled during breathing or coughing is the main cause for the propagation of the SARS-Cov-2. In this work, a URANS CFD approach was used to simulate the dispersion from the mouth of these particles in closed environments. The air conditioning system was considered. The conditions were varied to determine their impact on the diffusion of the aerosol. Lagrangian and Eulerian numerical approaches were used to model the coughing and the breathing events. These were validated with the puff theory, numerical and experimental results. A realistic case of a meeting room with two persons was simulated. Different characteristics of the expulsed aerosols and different ventilation system configurations were considered to demonstrate how these simulations can support management strategies for indoor occupation. Finally, the effect of the protective mask was introduced to quantify its beneficial effects to support safe indoor occupation.
Mixed effect modelling and variable selection for quantile regression
Authors: Bar Haim , Booth James G , Wells Martin T
Published: August 2021

It is known that the estimating equations for quantile regression (QR) can be solved using an EM algorithm in which the M-step is computed via weighted least squares, with weights computed at the E-step as the expectation of independent generalized inverse-Gaussian variables. This fact is exploited here to extend QR to allow for random effects in the linear predictor. Convergence of the algorithm in this setting is established by showing that it is a generalized alternating minimization (GAM) procedure. Another modification of the EM algorithm also allows us to adapt a recently proposed method for variable selection in mean regression models to the QR setting. Simulations show that the resulting method significantly outperforms variable selection in QR models using the lasso penalty. Applications to real data include a frailty QR analysis of hospital stays, and variable selection for age at onset of lung cancer and for riboflavin production rate using high-dimensional gene expression arrays for prediction.
High fidelity modeling tools for engine liner design and screening of advanced concepts
Authors: Winkler Julian , Mendoza Jeffrey M , Reimann C Aaron , Homma Kenji , Alonso Jose S
Published: August 2021

With aircraft engines trending toward ultra-high bypass ratios, resulting in lower fan pressure ratios, lower fan RPM, and therefore lower blade pass frequency, the aircraft engine liner design space has been dramatically altered. This result is also due to the associated reduction in both the available acoustic treatment area (axial extent) as well as thickness (liner depth). As a consequence, there is current need for novel acoustic liner technologies that are able to meet multiple physical constraints and simultaneously provide enhanced noise attenuation capabilities. In addition, recent advances in additive manufacturing have enabled the consideration of complex liner backing structures that would traditionally be limited to honeycomb cores. This paper provides an overview of engine liner modeling and a description of the key physical mechanisms, with some emphasis on the use of low to high-fidelity tools such as empirical models and commercially available software such as COMSOL, Actran, and PowerFLOW. It is shown that the higher fidelity tools are a critical enabler for the evaluation and construction of future complex liner structures. A systematic study is conducted to predict the acoustic performance of traditional single degree of freedom liners and comparisons are made to experimental data. The effects of grazing flow and bias flow are briefly addressed. Finally, a more advanced structure, a metamaterial, is modeled and the acoustic performance is discussed.
Examining the role of passion in university students’ academic emotions, self-regulated learning and well-being
Authors: Sverdlik Anna , Rahimi Sonia , Vallerand Robert J
Published: August 2021

University students’ passion for their studies has been previously demonstrated to be important for both their academic performance and their personal well-being. However, no studies to date have explored the role of passion for one’s studies on both academic and personal outcomes in a single model. The present research sought to determine the role of passion in adult university students’ self-regulated learning and psychological well-being (Study 1), as well as the process by which passion shapes these outcomes, namely academic emotions, in Study 2. It was hypothesised that harmonious passion would positively predict both self-regulated learning and psychological well-being in Study 1. Furthermore, the mediating role of academic emotions between passion and outcomes was tested using a prospective design over time in Study 2. Results provided support for the proposed model. Implications for future research and practice focusing on the role of passion in facilitating adaptive emotions, use of self-regulation and well-being in adult students are discussed.
What do specialist mental health professionals think of the mental health services for people with intellectual disabilities in Singapore?
Authors: Ee Jonathan , Kroese Biza Stenfert , Lim Jan Mei , Rose John
Published: August 2021

Background:

This research aimed to investigate the views and experiences of specialist mental health professionals working with adults with intellectual disabilities and mental health problems in Singapore in order to gain insight into the functioning of the local specialist intellectual disability mental health service and how it may be improved.

Methods:

Eight staff members from specialist service were interviewed. The transcriptions of the interviews were analysed using thematic analysis.

Results:

Analysis revealed four themes (1) Identifying their roles; (2) Ensuring continuity of care; (3) Disempowerment of service users and (4) Improving clinical practice.

Conclusions:

Participants identified the challenges they faced working with this population. They highlighted the importance of building therapeutic relationships during the treatment process and discussed the stigma that people with intellectual disabilities face in the community. Recommendations and implications are discussed in relation to service provision, improving staff knowledge and recruiting more staff to work in this field.
Does omitting the accent mark in a word affect sentence reading? Evidence from Spanish
Authors: Marcet Ana , Perea Manuel
Published: August 2021

Lexical stress in multisyllabic words is consistent in some languages (e.g., first syllable in Finnish), but it is variable in others (e.g., Spanish, English). To help lexical processing in a transparent language like Spanish, scholars have proposed a set of rules specifying which words require an accent mark indicating lexical stress in writing. However, recent word recognition using that lexical decision showed that word identification times were not affected by the omission of a word’s accent mark in Spanish. To examine this question in a paradigm with greater ecological validity, we tested whether omitting the accent mark in a Spanish word had a deleterious effect during silent sentence reading. A target word was embedded in a sentence with its accent mark or not. Results showed no reading cost of omitting the word’s accent mark in first-pass eye fixation durations, but we found a cost in the total reading time spent on the target word (i.e., including re-reading). Thus, the omission of an accent mark delays late, but not early, lexical processing in Spanish. These findings help constrain the locus of accent mark information in models of visual word recognition and reading. Furthermore, these findings offer some clues on how to simplify the Spanish rules of accentuation.
Short- and long-term exposure to air pollution increases the risk of stroke
Authors: Kim So Young , Kim Joo-Hee , Kim Yoo Hwan , Wee Jee Hye , Min Chanyang , Han Sang-Min , Kim Seungdo , Choi Hyo Geun
Published: August 2021

Objective

Many epidemiological studies have observed the association of air pollutant exposure with the onset, progression, and mortality of stroke. The aim of this study was to investigate the associations of air pollutants, including SO2, NO2, O3, CO, and PM10, with stroke according to exposure duration.

Methods

Data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 were obtained. The 21,240 patients who were admitted for or died due to stroke were 1:4 matched for age, sex, income, and region of residence with 84,960 control participants. The meteorological factors of mean, highest, and lowest temperatures; relative humidity; ambient atmospheric pressure; and air pollutant concentrations (SO2, NO2, O3, CO, and PM10) were analyzed to determine their associations with stroke. The odds ratios for stroke after exposure to each meteorological factor and air pollutant at 7 and 30 days were calculated in the stroke and control groups. Subgroup analyses were conducted according to age, sex, income, and region of residence.

Results

The odds ratio associated with seven days of exposure to CO was 1.16 (95% CI = 1.04–1.31) in stroke patients. For 30 days of exposure, the odds ratio associated with CO was 1.16 (95% CI = 1.02–1.32) in stroke patients. Seven and 30 days of NO2 exposure were inversely associated with stroke. The odds ratio associated with seven days of exposure to O3 was 1.16 (95% CI = 1.01–1.32) in ischemic stroke patients. Both ischemic and hemorrhagic stroke had negative associations with 7 and 30 days of NO2 exposure.

Conclusion

Both short- and long-term exposure to CO were related to stroke.
Idiopathic primary intraventricular hemorrhage and cerebral small vessel disease
Authors: Das Alvin S , Regenhardt Robert W , Gokcal Elif , Horn Mitchell J , Daoud Nader , Schwab Kristin M , Rost Natalia S , Viswanathan Anand , Taylor Kimberly W , Goldstein Joshua N , Biffi Alessandro , Schwamm Lee H , Rosand Jonathan , Greenberg Steven M , Gurol M Edip
Published: August 2021

Background

Although primary intraventricular hemorrhage is frequently due to trauma or vascular lesions, the etiology of idiopathic primary intraventricular hemorrhage (IP-IVH) is not defined.

Aims

Herein, we test the hypothesis that cerebral small vessel diseases (cSVD) including hypertensive cSVD (HTN-cSVD) and cerebral amyloid angiopathy are associated with IP-IVH.

Methods

Brain magnetic resonance imaging from consecutive patients (January 2011 to September 2019) with non-traumatic intracerebral hemorrhage from a single referral center were reviewed for the presence of HTN-cSVD (defined by strictly deep or mixed-location intracerebral hemorrhage/cerebral microbleeds) and cerebral amyloid angiopathy (applying modified Boston criteria).

Results

Forty-six (4%) out of 1276 patients were identified as having IP-IVH. Among these, the mean age was 74.4 ± 12.2 years and 18 (39%) were females. Forty (87%) had hypertension, and the mean initial blood pressure was 169.2 ± 40.4/88.8 ± 22.2 mmHg. Of the 35 (76%) patients who received a brain magnetic resonance imaging, two (6%) fulfilled the modified Boston criteria for possible cerebral amyloid angiopathy and 10 (29%) for probable cerebral amyloid angiopathy. Probable cerebral amyloid angiopathy was found at a similar frequency when comparing IP-IVH patients to the remaining patients with primary intraparenchymal hemorrhage (P-IPH) (27%, p = 0.85). Furthermore, imaging evidence for HTN-cSVD was found in 8 (24%) patients with IP-IVH compared to 209 (28%, p = 0.52) patients with P-IPH.

Conclusions

Among IP-IVH patients, cerebral amyloid angiopathy was found in approximately one-third of patients, whereas HTN-cSVD was detected in 23%—both similar rates to P-IPH patients. Our results suggest that both cSVD subtypes may be associated with IP-IVH.
PINK1/Parkin-mediated mitophagy in mechanical ventilation-induced diaphragmatic dysfunction
Authors: Yong Hui , Zhou Yun , Ye Wanlin , Li Tianmei , Wu Gangming , Chen Jingyuan , Liu Li , Wei Jicheng
Published: August 2021

Background:

Mechanical ventilation (MV) often leads to ventilation-induced diaphragm dysfunction (VIDD). Although the development of this disorder had been linked to oxidative stress, mitochondrial energy deficiency, autophagy activation, and apoptosis in the diaphragm, it remains unclear whether the activation of mitophagy can induce VIDD. With our research, our endeavor is to uncover whether PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy affects the MV-caused diaphragmatic dysfunction

Methods:

Sprague-Dawley rats were subjected to MV treatment for 6 h (MV-6h), 12 h (MV-12h), or 24 h (MV-24h). Post MV, the diaphragm muscle compound action potential (CMAP) and cross-sectional areas (CSAs) of the diaphragm of these rats were measured. The levels of proteins of interest were examined to assess muscle health, mitochondrial dynamics, and mitophagy in the diaphragm. The co-localization of PINK1 with the mitochondrial protein marker tom20 was examined, as well as transmission electron microscopy analysis to detect changes in diaphragm mitochondrial ultrastructure.

Results:

MV-12h and MV-24h treatments resulted in a decrease in CSA of diaphragm and CMAP amplitude. In addition, the expressions of F-box (MFAbx), muscle-specific ring finger 1 (MURF1), PINK1, and p62 were elevated in rats treated with MV for 12 h and 24 h, while mfn2 expression was reduced. Rats following MV-24h treatment displayed an increase in mitochondrial dynamic protein (Drp1) and Parkin expression and microtubule-associated protein 1 light chain 3/1 (LC3II/I) ratio. Moreover, decreased SOD and GSH activity and membrane potential were observed after MV-12h and MV-24h treatment, while H2O2 activity increased after MV-24h treatment. In addition, a strong co-localization between PINK1 and tom20 was identified.

Conclusion:

These results reveal that MV leads to various changes in mitochondrial dynamics and significantly increases the mitophagy levels, which subsequently cause the variation in diaphragmatic function and muscle atrophy, indicating that mitophagy could be one of the possible mechanisms by which MV induces diaphragmatic dysfunction. The reviews of this paper are available via the supplemental material section.
Antimycobacterial Activity of the Extract and Isolated Compounds From the Stem Bark of Zanthoxylum leprieurii Guill. and Perr.
Authors: Oloya Benson , Namukobe Jane , Heydenreich Matthias , Ssengooba Willy , Schmidt Bernd , Byamukama Robert
Published: August 2021

Zanthoxylum leprieurii Guill. and Perr. (Rutaceae) stem bark is used locally in Uganda for treating tuberculosis (TB) and cough-related infections. Lupeol (1), sesamin (2), trans-fagaramide (3), arnottianamide (4), ( S)-marmesinin (5), and hesperidin (6) were isolated from the chloroform/methanol (1:1) extract of Z. leprieurii stem bark. Their structures were elucidated using spectroscopic techniques and by comparison with literature data. Furthermore, the extract and isolated compounds were subjected to antimycobacterial activity. The extract exhibited moderate activity against the susceptible (H37Rv) TB strain, but weak activity against the multidrug resistant (MDR)-TB strain with minimum inhibitory concentrations (MICs) of 586.0 and 1172.0 μg/mL, respectively. Compound 3 (trans-fagaramide) showed significant antimycobacterial activity against the susceptible (H37Rv) TB strain (MIC 6 μg/mL), but moderate activity against the MDR-TB strain (MIC 12.2 μg/mL). Compounds 2, 5, 6, and 1 showed moderate activities against the susceptible (H37Rv) strain (MIC 12.2-98.0 μg/mL) and moderate to weak activities against the MDR-TB strain (MIC 24.4-195.0 μg/mL). This study reports for the first time the isolation of compounds 1 to 6 from the stem bark of Z leprieurii. trans-Fagaramide (3) may present a vital template in pursuit of novel and highly effective TB drugs.
Stem Cells in Orthopedic Web Information: An Assessment with the DISCERN Tool
Authors: Venosa Michele , Tarantino Alessio , Schettini Irene , Padua Roberto , Cifone Maria Grazia , Calvisi Vittorio , Romanini Emilio
Published: August 2021

Objective

Regenerative medicine is experiencing a strong expansion worldwide, including the treatment of some common orthopedic pathologies, with an increase in physicians adopting these technologies. This growing interest has been associated with an equally significant spread of websites dedicated to public information on this topic, often lacking scientific bases. This study aims to evaluate the quality of information on the World Wide Web about stem cells for cartilage disorders in orthopedic practice.

Design

On February 19, 2021 we performed a search on Google using as keywords “cartilage stem cells,” considering only the freely accessible sites in Italian, English, French, and Spanish. We selected the first 50 valid results for each language and evaluated them using the DISCERN scale.

Results

A total of 249 sites were observed, of which 49 were discarded as duplicates (8) or not relevant to the topic (41). Of the 200 sites surveyed, 47 were affiliated to a singular surgeon (23.5%), 31 to private stakeholders (15.5%), 73 to information sites (36.5%), 8 to public hospitals (4%), 13 to universities (6.5%), and 28 referred to international scientific journals (14%). Only 76 sites (38%) were rated as fair or better, while the remaining 124 (62%) were classified as poor or very poor.

Conclusions

The quality of the information promoted for stem cells in orthopedics is generally low, although a significant minority of the sites offers good quality information. A greater commitment on the part of surgeons and other stakeholders is desirable to promote information on regenerative medicine through scientific criteria supported by adequate literature.
Diagnostic utility of parasagittal measurements of tonsillar herniation in Chiari I malformation
Authors: Ebrahimzadeh Seyed Amir , Loth Francis , Ibrahimy Alaaddin , Nwotchouang Blaise Simplice Talla , Bhadelia Rafeeque A
Published: August 2021

Background and purpose

Although the cerebellar tonsils are parasagittal structures, the extent of tonsillar herniation (ETH) in Chiari I malformation (CMI) is currently measured in the midsagittal plane. We measured the ETH of each cerebellar tonsil in the parasagittal plane and assessed their diagnostic utility by comparing them to the midsagittal ETH measurements in predicting cough-associated headache (CAH), an indicator of clinically significant disease in CMI.

Methods

Eighty-five CMI patients with 3D-MPRAGE images were included. Neurosurgeons determined the presence of CAH. Sagittal images were used to measure ETH in the midsagittal (MS_ETH) and parasagittal planes (by locating tonsillar tips on each side on reformatted coronal images). Given the parasagittal ETH (PS_ETH) asymmetry in the majority of cases, they were considered Smaller_PS_ETH or Larger_PS_ETH. The accuracy of ETH measurements was assessed by the receiver operating characteristic (ROC) curve.

Results

Of 85 patients, 46 reported CAH. ROC analysis showed an area under the curve (AUC) of 0.78 for Smaller_PS_ETH significantly better than 0.65 for MS-ETH in predicting CAH ( p = 0.001). An AUC of 0.68 for Larger_PS_ETH was not significantly different from MS_ETH. The sensitivity and specificity of predicting CAH were 87% and 28% for MS_ETH >6 mm versus 90% and 46% for Smaller_PS_ETH >6 mm, and 52% and 67% for MS_ETH >9 mm versus 48% and 87% for Smaller_PS_ETH >9 mm. At ETH >15 mm, no differences were seen between the measurements.

Conclusions

Diagnostic utility of ETH measurements in detecting clinically significant CMI can be improved by parasagittal measurements of the cerebellar tonsillar herniation.
Infectious complications of CAR T-cell therapy: a clinical update
Authors: Stewart Adam G. , Henden Andrea S.
Published: August 2021

Chimeric antigen receptor (CAR) T-cell therapy is a revolutionary treatment modality used to treat haematological malignancies. Lymphocytes are engineered to produce CARs directed towards tumour cell antigens. Clinical trials have demonstrated impressive malignancy-related outcomes. Unfortunately, numerous off-target effects can cause toxicity-related adverse events in this population, the main being cytokine release syndrome and immune effector cell neurotoxicity syndrome. This causes significant patient morbidity and poor outcomes. Patients who receive CAR T-cell therapy are also profoundly immunosuppressed and often cytopenic, which is caused by a multitude of patient- and treatment-related factors. Thus, infection-related complications are also common in this group. Indeed, up to one third of patients will suffer a serious bacterial infection in the first 30 days after therapy. Viral respiratory tract infection appears to be the most common during the late phase and can be severe; one patient has died of influenza A infection. Fungal infection and cytomegalovirus (CMV) reactivation appear to be uncommon. Although institutional guidelines on infection-prevention strategies are available, there is a dearth of evidence to support their approach. Future research needs to target important unanswered questions that remain in this patient population in order to improve their short- and long-term outcomes.
Using a Critical Safety Behavior Scoring Tool for Just-in-Time Training for N95 Respirator Use
Authors: Herstein Jocelyn J. , Gibbs Shawn G. , Kupzyk Kevin A. , Beam Elizabeth L.
Published: August 2021

Background

Historically, health care workers (HCWs) have exhibited marginal adherence to proper N95 respirator use. During the COVID-19 pandemic, HCWs with little to no prior training on N95 respirator use are relying on N95s as their primary respiratory protection. There is a need for simple, effective, and easily implementable just-in-time training (JITT) interventions to improve N95 respirator-related safety behavior. This study investigated two JITT interventions.

Methods

A pilot experimental pretest posttest study design was used to evaluate two training interventions for N95 respirator donning/doffing performance at a Midwestern hospital system. HCW participants were randomly assigned to an intervention: one used a 4-minute instructional video alone, while the other used the same video but added a video reflection intervention (participant watched and scored a video of their own performance). All performances were scored using a 10-point Critical Safety Behavior Scoring Tool (CSBST).

Findings

Sixty-two HCWs participated (32 video alone, 30 video reflection). The two groups’ CSBST scores were not significantly different at pretest. Averaged participant scores on the CSBST improved immediately following both interventions. Scores were significantly higher on the posttest for the reflective practice intervention ( p<.05). Years of experience and frequency of N95 respirator use did not predict pre or post scores.

Conclusions/Applications to Practice

We provide evidence to support the use of a time-efficient JITT intervention to improve HCW N95 respirator donning/doffing practices during the COVID-19 pandemic and beyond. Hospital safety professionals should consider this type of training for HCWs required to wear respiratory protection.
Perpetually Positive: Post-COVID Interstitial Lung Disease in an Immunocompromised Patient With Diffuse Large B-cell Lymphoma
Authors: Dayco John S. , El-Reda Zeinab , Sumbal Nabeel , Alhusain Rashid , Raheem Shaheena
Published: August 2021

As more patients recover from COVID-19 infection, long-term complications are beginning to arise. Our case report will explore a debilitating long-term complication, Post-COVID Interstitial Lung Disease (PC-ILD). We will introduce a patient who developed PC-ILD in the setting of diffuse large B-cell lymphoma, outlining a difficult hospital course, including a positive COVID-19 polymerase chain reaction (PCR) for more than 3 months. We will then discuss the human body’s physiological response to the virus and how our patient was not able to adequately mount an immune response. Finally, the pathophysiology of PC-ILD will be explored and correlated with the patient’s subsequent computed tomographic images obtained over a 3-month period. The difficult hospital course and complex medical decision-making outlined in this case report serve as a reminder for health care providers to maintain vigilance in protecting our most vulnerable patient population from such a devastating disease process.
Relationship Between Cognitive Performance and Lower Extremity Biomechanics: Implications for Sports-Related Concussion
Authors: Avedesian Jason M. , Covassin Tracey , Baez Shelby , Nash Jennifer , Nagelhout Ed , Dufek Janet S.
Published: August 2021

Background:

Collegiate athletes with prior sports-related concussion (SRC) are at increased risk for lower extremity (LE) injuries; however, the biomechanical and cognitive mechanisms underlying the SRC-LE injury relationship are not well understood.

Purpose:

To examine the association between cognitive performance and LE land-and-cut biomechanics among collegiate athletes with and without a history of SRC and to determine the association among multiple cognitive testing batteries in the same athlete cohort.

Study Design:

Controlled laboratory study.

Methods:

A cohort of 20 collegiate athletes with prior SRC (9 men, 11 women; mean ± standard deviation [SD] age, 20.5 ± 1.3 years; mean ± SD time since last SRC, 461 ± 263 days) and 20 matched controls (9 men, 11 women; mean ± SD age, 19.8 ± 1.3 years) completed land-and-cut tasks using the dominant and nondominant limbs. LE biomechanical variables and a functional visuomotor reaction time (FVMRT) were collected during each trial. Athletes also completed the Immediate Post-Concussion Assessment and Cognitive Test (ImPACT) and Senaptec Sensory Station assessments.

Results:

In the SRC cohort, Pearson correlation coefficients indicated slower FVMRT was moderately correlated with decreased dominant limb ( r = –0.512) and nondominant limb ( r = –0.500) knee flexion, while increased dominant limb knee abduction moment was moderately correlated with decreased ImPACT Visual Memory score ( r = –0.539) and slower ImPACT Reaction Time ( r = 0.515). Most computerized cognitive measures were not associated with FVMRT in either cohort ( P > .05).

Conclusion:

Decreased reaction time and working memory performance were moderately correlated with decreased sagittal plane knee motion and increased frontal plane knee loading in collegiate athletes with a history of SRC. The present findings suggest a potential unique relationship between cognitive performance and LE neuromuscular control in athletes with a history of SRC injury. Last, we determined that computerized measures of cognitive performance often utilized for SRC management are dissimilar to sport-specific cognitive processes.

Clinical Relevance:

Understanding the relationship between cognitive performance and LE biomechanics in athletes with prior SRC may inform future clinical management strategies. Future research should prospectively assess cognitive and biomechanical measures, along with LE injury incidence, to identify mechanisms underlying the SRC-LE injury relationship.
How an Antiscience President and the COVID-19 Pandemic Altered the Career Trajectories of STEM PhD Students of Color
Authors: McGee Ebony , Fang Yuan , Ni Yibin (Amanda) , Monroe-White Thema
Published: August 2021

In this mixed-methods study, we performed content analysis on openended survey items to reveal primary themes related to how PhD students are responding to the Trump policies and the COVID-19 pandemic. In our data set, 40.7% of the respondents reported that their career plans have been affected by Trump’s antiscience policies, 54.5% by the COVID-19 pandemic. Our study revealed three themes, which were (1) awareness of the reduced funding for STEM (science, engineering, technology, and mathematics) and higher education, (2) heightened awareness of and commitment to the pursuit of social and racial justice, (3) interest in seeking job opportunities abroad. The top three themes for the COVID-19 pandemic were (1) shifting graduation timelines and adjusting research to the virtual campus life; (2) losing jobs, concerning about hiring freezes and fewer job openings; and (3) reconsidering their place in a STEM field postpandemic, including a possible complete change in career plans; thoughts of leaving the country for international jobs.
The birth of motion capture: Transcribing the phenomena of bodily movement through the “graphic method”
Authors: Paterson Mark
Published: August 2021

How is the movement of bodies recorded, traced, captured? How is the perception of movement decomposed, analyzed, and then reconstructed through signs, lines, and diagrams? This article traces how, with the help of engineers and collaborators, Etienne-Jules Marey’s self-styled “graphic method” innovated upon existing instruments and photographic apparatuses in order to capture not just the movement of horses’ legs but something of the biomechanical essence of animal movement through the technique of “chronophotographie.” Although inspired by Edward Muybridge’s photographs of horses in motion, for Marey the photographs were not the end result. What he achieved were new ways of transcribing the phenomena of bodily motion. Unlike previous physiologists who thrived on vivisection in the laboratory, Marey took ever greater pains to examine the principles of animal movement in the wild, and built an open-air “station physiologique” in a Parisian park for this purpose. One legacy of Marey’s chronophotographic technique was in the documentation and dissection of human movement, and became acknowledged precursors of the wave of Taylorism which would sweep industrial research in the early 20th century. But another legacy is the capacity to transcribe the phenomena of movement into other forms, externalizing perception across other media.
Lack of differential impact of del17p on survival in African Americans compared with White patients with multiple myeloma: a VA study
Authors: Fillmore Nathanael R. , Cirstea Diana , Munjuluri Anusha , Yameen Hassan , Yellapragada Sarvari V. , Do Nhan V. , Brophy Mary T. , Szalat Raphael E. , Munshi Nikhil C.
Published: August 2021

Multiple myeloma (MM) is a heterogeneous disease that has an increased incidence in African Americans (AAs). We previously observed that, with equal access to health care, younger AA patients (age < 65 years) have superior overall survival (OS) compared with younger White patients. Because MM prognosis is influenced by 17p deletion (del17p), we investigated racial differences in its occurrence and impact in a large cohort of MM patients from the Veterans Affairs (VA) system. Among 2243 VA patients with MM for whom del17p data were available, del17p was present in 8.83% of all patients, with a significantly lower prevalence in AAs (5.56%) compared with Whites (10.52%; P < .001). The difference was even more pronounced among younger AAs (<65 years) vs younger Whites (4.34% vs 9.8%, respectively; P = .004). However, we did not observe any significant difference in survival between AA and White patients with del17p, regardless of age category, suggesting that del17p carries a poor prognosis across race and age. Interestingly, among patients without del17p, we still noted a significantly superior OS in younger AAs compared with younger Whites (7.75 vs 5.10 years; P = .042). Our study shows a lower incidence of del17p in AAs but suggests that the survival advantage for younger AAs is primarily due to factors other than del17p.
Group problem solving therapy for perinatal depression in primary health care settings in rural Uganda: an intervention cohort study
Authors: Nakku Juliet E. M. , Nalwadda Oliva , Garman Emily , Honikman Simone , Hanlon Charlotte , Kigozi Fred , Lund Crick
Published: August 2021

Background

Perinatal depression is of substantial public health importance in low and middle income countries. The study aimed to evaluate the impact of a mental health intervention delivered by non-specialist health workers on symptom severity and disability in women with perinatal depression in Uganda.

Methods

Pregnant women in the second and third trimester were consecutively screened using the Luganda version of the 9-item Patient Health Questionnaire (PHQ-9). Women who scored ≥5 on the PHQ-9 and who were confirmed to have depression by a midwife were recruited into a treatment cohort and offered a psychological intervention in a stepped care fashion. Women were assessed with PHQ-9 and WHODAS-2.0 at baseline and again at 3 and 6 months after the intervention. Negative regression analysis was done to examine change in PHQ-9 and WHODAS-2.0 scores from baseline to end line. Data were analysed using STATA version 14.

Results

A total of 2652 pregnant women (98.3%) consented to participate in the study and 153 (5.8%) were diagnosed as depressed. Over a quarter (28.8%) reported having experienced physical interpersonal violence (IPV) while (25.5%) reported sexual IPV in the past year. A third (34.7%) of women diagnosed with depression received 4 or more group PST sessions. There was a mean reduction in PHQ-9 score of 5.13 (95%CI − 6.79 to − 3.47, p < 0.001) and 7.13 (95%CI − 8.68 to − 5.59, p < 0.001) at midline and endline, respectively. WHODAS scores reduced significantly by − 11.78 points (CI 17.64 to − 5.92, p < 0.001) at midline and − 22.92 points (CI 17.64 to − 5.92, p < 0.001) at endline. Clinical response was noted among 69.1% (95%CI 60.4–76.6%) and 93.7% (95%CI 87.8–96.8%) of respondents at midline and endline, respectively.

Conclusion

An evidence based psychological intervention implemented in primary antenatal care by trained and supervised midwives in a real-world setting may lead to improved outcomes for women with perinatal depression. Future randomised studies are needed to confirm the efficacy of this intervention and possibility for scale up.
Iron accumulation deteriorated bone loss in estrogen-deficient rats
Authors: Liu Lu-lin , Liu Gong-wen , Liu Hui , Zhao Kai , Xu You-jia
Published: August 2021

Background

Postmenopausal osteoporosis is characterized by an imbalance of bone resorption exceeding bone formation, resulting in a net loss of bone mass. Whether a menopause-related excess of iron contributes to the development of postmenopausal osteoporosis has remained unresolved due to a lack of an appropriate animal model. This study aimed to explore the effects of iron accumulation in bone mass in estrogen-deficient rats.

Methods

In the present study, ovariectomy (OVX) was performed in female rats and the changes of iron metabolism and some related modulated genes were detected. Ferric ammonium citrate (FAC) was used as a donor of iron for OVX rats. Moreover, micro-CT was performed to assess the bone microarchitecture in sham group, OVX, and FAC groups. Histological detection of iron in liver was assessed by Perl’s staining. The expressions of β-CTX and osteocalcin were assessed by ELISA.

Results

It was found that serum iron decreased after OVX. It was found that the expressions of Hepcidin in liver and Fpn, DMT-1 in duodenum significantly decreased at transcriptional level in OVX group than sham group. However, no difference existed in the expression of DMT-1. Then, ferric ammonium citrate (FAC) was used as a donor of iron for OVX rats. The FAC group manifested significant iron accumulation by increased serum iron and hepatic iron content. In addition, FAC treatment accelerated bone loss and decreased BMD and biomechanics in OVX rats. Moreover, bone biomarker β-CTX rather than osteocalcin increased significantly in FAC groups than OVX group.

Conclusions

In conclusion, no iron accumulation occurred in OVX rats. Furthermore, iron accumulation could further deteriorate osteopenia through enhanced bone resorption.
Somatostatin contributes to long-term potentiation at excitatory synapses onto hippocampal somatostatinergic interneurons
Authors: Racine Anne-Sophie , Michon François-Xavier , Laplante Isabel , Lacaille Jean-Claude
Published: August 2021

Somatostatin-expressing interneurons (SOM-INs) are a major subpopulation of GABAergic cells in CA1 hippocampus that receive excitation from pyramidal cells (PCs), and, in turn, provide feedback inhibition onto PC dendrites. Excitatory synapses onto SOM-INs show a Hebbian long-term potentiation (LTP) mediated by type 1a metabotropic glutamate receptors (mGluR1a) that is implicated in hippocampus-dependent learning. The neuropeptide somatostatin (SST) is also critical for hippocampal long-term synaptic plasticity, as well as learning and memory. SST effects on hippocampal PCs are well documented, but its actions on inhibitory interneurons remain largely undetermined. In the present work, we investigate the involvement of SST in long-term potentiation of CA1 SOM-IN excitatory synapses using pharmacological approaches targeting the somatostatinergic system and whole cell recordings in slices from transgenic mice expressing eYFP in SOM-INs. We report that application of exogenous SST14 induces long-term potentiation of excitatory postsynaptic potentials in SOM-INs via somatostatin type 1–5 receptors (SST1-5Rs) but does not affect synapses of PC or parvalbumin-expressing interneurons. Hebbian LTP in SOM-INs was prevented by inhibition of SSTRs and by depletion of SST by cysteamine treatment, suggesting a critical role of endogenous SST in LTP. LTP of SOM-IN excitatory synapses induced by SST14 was independent of NMDAR and mGluR1a, activity-dependent, and prevented by blocking GABAA receptor function. Our results indicate that endogenous SST may contribute to Hebbian LTP at excitatory synapses of SOM-INs by controlling GABAA inhibition, uncovering a novel role for SST in regulating long-term synaptic plasticity in somatostatinergic cells that may be important for hippocampus-dependent memory processes.
CogTale: an online platform for the evaluation, synthesis, and dissemination of evidence from cognitive interventions studies
Authors: Sabates Julieta , Belleville Sylvie , Castellani Mary , Dwolatzky Tzvi , Hampstead Benjamin M. , Lampit Amit , Simon Sharon , Anstey Kaarin , Goodenough Belinda , Mancuso Serafino , Marques Davis , Sinnott Richard , Bahar-Fuchs Alex
Published: August 2021

Systematic reviews and meta-analyses are critical in health-related decision-making, and are considered the gold standard in research synthesis methods. However, with new trials being regularly published and with the development of increasingly rigorous standards of data synthesis, systematic reviews often require much expertise and long periods of time to be completed. Automation of some of the steps of evidence synthesis productions is a promising improvement in the field, capable of reducing the time and costs associated with the process.

This article describes the development and main characteristics of a novel online repository of cognitive intervention studies entitled Cognitive Treatments Article Library and Evaluation (CogTale). The platform is currently in a Beta Release phase, as it is still under development. However, it already contains over 70 studies, and the CogTale team is continuously coding and uploading new studies into the repository. Key features include advanced search options, the capability to generate meta-analyses, and an up-to-date display of relevant published studies.
Estimation of divergences on time scales via the Green function and Fink’s identity
Authors: Ansari Iqrar , Khan Khuram Ali , Nosheen Ammara , Pečarić Ðilda , Pečarić Josip
Published: August 2021

The aim of the present paper is to obtain new generalizations of an inequality for n-convex functions involving Csiszár divergence on time scales using the Green function along with Fink’s identity. Some new results in h-discrete calculus and quantum calculus are also presented. Moreover, inequalities for some divergence measures are also deduced.
Nitrogen addition mediates the response of foliar stoichiometry to phosphorus addition: a meta-analysis
Authors: You Chengming , Peng Changhui , Xu Zhenfeng , Liu Yang , Zhang Li , Yin Rui , Liu Lin , Li Han , Wang Lixia , Liu Sining , Tan Bo , Kardol Paul
Published: August 2021

Background

Changes in foliar nitrogen (N) and phosphorus (P) stoichiometry play important roles in predicting the effects of global change on ecosystem structure and function. However, there is substantial debate on the effects of P addition on foliar N and P stoichiometry, particularly under different levels of N addition. Thus, we conducted a global meta-analysis to investigate how N addition alters the effects of P addition on foliar N and P stoichiometry across different rates and durations of P addition and plant growth types based on more than 1150 observations.

Results

We found that P addition without N addition increased foliar N concentrations, whereas P addition with N addition had no effect. The positive effects of P addition on foliar P concentrations were greater without N addition than with N addition. Additionally, the effects of P addition on foliar N, P and N:P ratios varied with the rate and duration of P addition. In particular, short-term or low-dose P addition with and without N addition increased foliar N concentration, and the positive effects of short-term or low-dose P addition on foliar P concentrations were greater without N addition than with N addition. The responses of foliar N and P stoichiometry of evergreen plants to P addition were greater without N addition than with N addition. Moreover, regardless of N addition, soil P availability was more effective than P resorption efficiency in predicting the changes in foliar N and P stoichiometry in response to P addition.

Conclusions

Our results highlight that increasing N deposition might alter the response of foliar N and P stoichiometry to P addition and demonstrate the important effect of the experimental environment on the results. These results advance our understanding of the response of plant nutrient use efficiency to P addition with increasing N deposition.