bluuebunny/crossref_metadata_2025 huggingface dataset:
Ultrasonic-Assisted Incremental Microforming of Thin Shell Pyramids of Metallic Foil
Authors: Obikawa Toshiyuki , Hayashi Mamoru
Published: May 2017

Single point incremental forming is used for rapid prototyping of sheet metal parts. This forming technology was applied to the fabrication of thin shell micropyramids of aluminum, stainless steel, and titanium foils. A single point tool used had a tip radius of 0.1 mm or 0.01 mm. An ultrasonic spindle with axial vibration was implemented for improving the shape accuracy of micropyramids formed on 5–12 micrometers-thick aluminum, stainless steel, and titanium foils. The formability was also investigated by comparing the forming limits of micropyramids of aluminum foil formed with and without ultrasonic vibration. The shapes of pyramids incrementally formed were truncated pyramids, twisted pyramids, stepwise pyramids, and star pyramids about 1 mm in size. A much smaller truncated pyramid was formed only for titanium foil for qualitative investigation of the size reduction on forming accuracy. It was found that the ultrasonic vibration improved the shape accuracy of the formed pyramids. In addition, laser heating increased the forming limit of aluminum foil and it is more effective when both the ultrasonic vibration and laser heating are applied.
RF Sputtering, Post-Annealing Treatment and Characterizations of ZnO (002) Thin Films on 3C-SiC (111)/Si (111) Substrates
Authors: Valliyil Sasi Visakh , Iqbal Abid , Chaik Kien , Iacopi Alan , Mohd-Yasin Faisal
Published: May 2017

We report on the radio frequency (RF) sputtering of c-axis oriented ZnO thin films on top of epitaxial 3C-SiC-on-Si (111) substrates, which were then subjected to post-annealing treatment at 400, 600 and 800 °C. Grazing incident X-ray Diffraction (XRD) data show that the Full Width Half Maximum (FWHM) values for O2/Ar ratios between 30% and 60% are consistent, with a mean of 0.325° and a standard deviation of 0.03°. This is largely attributed to the smaller lattice mismatch of 5% between the ZnO (002) and SiC (111) films. The quality of the ZnO films deteriorated at the post-annealing treatment of 800 °C, as demonstrated by the increasing value of FWHM diffraction peaks, the reducing value of the peak intensity, the reducing percentage of (002) oriented area under the curve, and the increasing value of biaxial stress. We propose a simple growth model to explain the result.
Preparation of an Acridinium Ester-Labeled Antibody and Its Application in GoldMag Nanoparticle-Based, Ultrasensitive Chemiluminescence Immunoassay for the Detection of Human Epididymis Protein 4
Authors: Ma Ting , Zhang Mengdan , Wan Yinsheng , Cui Yali , Ma Le
Published: May 2017

An ultrasensitive and rapid sandwich-type chemiluminescence immunoassay (CLIA) was developed for the clinical determination of human epididymis protein 4 (HE4) in human serum, using GoldMag nanoparticles as solid phase and acridinium ester (AE) as chemiluminescence system (GMP-CLIA). The process of AE labeling antibodies was systematically studied and evaluated. The effect of varies factors such as molar ratio of AE to antibodies, labeling time, and the components of elution buffer and trigger solution were optimized. Under the selected conditions, AE labeling experiments were successfully performed with the average labeling efficiency of 1.92 ± 0.08, and antibody utilization rate of 69.77 ± 1.19%. Antibody activity remained unchanged after labeling. The established GMP-CLIA method can detect HE4 in the range of 0.25–50 ng·mL−1 (10–2000 pM) with a detection limit of 0.084 ng·mL−1 (3.36 pM). The sensitivity has reached a high level, comparable with the current commercial detection kits. This proposed method has been successfully applied to the clinical determination of HE4 in 65 human sera. The results showed a good correlation with a clinical method, microplate-based chemiluminescence enzyme immunoassay (CLEIA), with the correlation coefficient of 0.9594.
Multi-Anti-Parasitic Activity of Arylidene Ketones and Thiazolidene Hydrazines against Trypanosoma cruzi and Leishmania spp.
Authors: Álvarez Guzmán , Perdomo Cintya , Coronel Cathia , Aguilera Elena , Varela Javier , Aparicio Gonzalo , Zolessi Flavio , Cabrera Nallely , Vega Celeste , Rolón Miriam , Rojas de Arias Antonieta , Pérez-Montfort Ruy , Cerecetto Hugo , González Mercedes
Published: May 2017

A series of fifty arylideneketones and thiazolidenehydrazines was evaluated against Leishmania infantum and Leishmania braziliensis. Furthermore, new simplified thiazolidenehydrazine derivatives were evaluated against Trypanosoma cruzi. The cytotoxicity of the active compounds on non-infected fibroblasts or macrophages was established in vitro to evaluate the selectivity of their anti-parasitic effects. Seven thiazolidenehydrazine derivatives and ten arylideneketones had good activity against the three parasites. The IC50 values for T. cruzi and Leishmania spp. ranged from 90 nM–25 µM. Eight compounds had multi-trypanocidal activity against T. cruzi and Leishmania spp. (the etiological agents of cutaneous and visceral forms). The selectivity of these active compounds was better than the three reference drugs: benznidazole, glucantime and miltefosine. They also had low toxicity when tested in vivo on zebrafish. Trying to understand the mechanism of action of these compounds, two possible molecular targets were investigated: triosephosphate isomerase and cruzipain. We also used a molecular stripping approach to elucidate the minimal structural requirements for their anti-T. cruzi activity.
Acetylcholinesterase Inhibitory Meroterpenoid from a Mangrove Endophytic Fungus Aspergillus sp. 16-5c
Authors: Long Yuhua , Cui Hui , Liu Xinglie , Xiao Ze’en , Wen Shitong , She Zhigang , Huang Xishan
Published: May 2017

One new meroterpenoid, named 2-hydroacetoxydehydroaustin (1), together with nine known meroterpenoids, 11-acetoxyisoaustinone (2), isoaustinol (3), austin (4), austinol (5), acetoxydehydroaustin (6), dehydroaustin (7), dehydroaustinol (8), preaustinoid A2 (9), and 1,2-dihydro-acetoxydehydroaustin B (10), were isolated from the mangrove endophytic fungus, Aspergillus sp. 16-5c. These structures were characterized by spectroscopic analysis, further the absolute configurations of stereogenic carbons for Compounds 1, 3, 4, 6, 7, 8, 9, and 10 were determined by single crystal X-ray diffraction analysis using Cu Kα radiation. Moreover, the absolute configurations of stereogenic carbons for Known Compounds 3, 7, 8, and 9 are identified here for the first time. Compounds 3, 7, and 8 showed acetylcholinesterase (AchE) inhibitory activity with IC50 values of 2.50, 0.40, and 3.00 μM, respectively.
Assessing Scaffold Diversity of Kinase Inhibitors Using Alternative Scaffold Concepts and Estimating the Scaffold Hopping Potential for Different Kinases
Authors: Dimova Dilyana , Bajorath Jürgen
Published: May 2017

Publicly available kinase inhibitors provide a large source of information for structure–activity relationship analysis and kinase drug design. In this study, publicly available inhibitors of the human kinome were collected and analog series formed by kinase inhibitors systematically identified. Then, alternative scaffold concepts were applied to assess diversity and promiscuity of kinase inhibitors. Over the past two years, the number of publicly available kinase inhibitors with high-confidence activity data more than doubled, but coverage of the human kinome only slightly increased. Approximately 70% of current kinase inhibitors belonged to analog series. However, the detectable degree of promiscuity among these kinase inhibitors remained low. Approximately 76% of all inhibitors were only annotated with a single kinase, compared to ~70% two years ago. For many kinases, the assessment of scaffold diversity among their inhibitors and the distribution of differently defined scaffolds over analog series made it possible to assess scaffold hopping potential. Our analysis revealed that the consideration of conventional compound-based scaffolds most likely leads to an overestimation of scaffold hopping frequency, at least for compounds forming analog series.
Ontogenetic Variation of Individual and Total Capsaicinoids in Malagueta Peppers (Capsicum frutescens) during Fruit Maturation
Authors: Fayos Oreto , De Aguiar Ana , Jiménez-Cantizano Ana , Ferreiro-González Marta , Garcés-Claver Ana , Martínez Julián , Mallor Cristina , Ruiz-Rodríguez Ana , Palma Miguel , Barroso Carmelo , Barbero Gerardo
Published: May 2017

The ontogenetic variation of total and individual capsaicinoids (nordihydrocapsaicin (n-DHC), capsaicin (C), dihydrocapsaicin (DHC), homocapsaicin (h-C) and homodihydrocapsaicin (h-DHC)) present in Malagueta pepper (Capsicum frutescens) during fruit ripening has been studied. Malagueta peppers were grown in a greenhouse under controlled temperature and humidity conditions. Capsaicinoids were extracted using ultrasound-assisted extraction (UAE) and the extracts were analyzed by ultra-performance liquid chromatography (UHPLC) with fluorescence detection. A significant increase in the total content of capsaicinoids was observed in the early days (between 12 and 33). Between day 33 and 40 there was a slight reduction in the total capsaicinoid content (3.3% decrease). C was the major capsaicinoid, followed by DHC, n-DHC, h-C and h-DHC. By considering the evolution of standardized values of the capsaicinoids it was verified that n-DHC, DHC and h-DHC (dihydrocapsaicin-like capsaicinoids) present a similar behavior pattern, while h-C and C (capsaicin-like capsaicinoids) show different evolution patterns.
Tuning the Geometrical Structures and Optical Properties of Blue-Emitting Iridium(III) Complexes through Dimethylamine Substitutions: A Theoretical Study
Authors: Ren Xue-Feng , Tang Hong-Qu , Kang Guo-Jun
Published: May 2017

The geometrical structures and photophysical properties of Ir(4,6-dFppy)2(pic) (FIrpic) and its derivative (o-FIr, m-FIr, p-FIr) with dimethylamine substituted at the picolinic acid (N∧O) ligand were fully investigated by density functional theory and time-dependent density functional theory. The simulated electronic structure, as well as absorption and emission spectra of FIrpic are in good agreement with the experimental observations. The introduction of dimethylamine at the N∧O ligand at different positions is beneficial to extend the π-electron delocalization, increase HOMO energy levels, and hence improve the hole injection and transfer ability compared with those of FIrpic. Furthermore, o-FIr, m-FIr, and p-FIr have large absorption intensity and participation of metal-to-ligand charge transfer (MLCT) contribution in the main absorption spectra, which would be useful to improve the intersystem crossing (ISC) from the singlet to triplet excited state. More importantly, the high quantum yield of o-FIr (which is explained based on the detailed analysis of triplet energy, ET1), participation of 3MLCT contribution in the phosphorescent spectra, and energy difference between 3MLCT and triplet metal centered (3MC) d-d excited state compared with m-FIr and p-FIr indicate that o-FIr is expected to be an excellent blue phosphorescence emitter with high efficiency.
Two New Metabolites from the Endophytic Fungus Alternaria sp. A744 Derived from Morinda officinalis
Authors: Wang Ying , Liu Hong-Xin , Chen Yu-Chan , Sun Zhang-Hua , Li Hao-Hua , Li Sai-Ni , Yan Ming-Li , Zhang Wei-Min
Published: May 2017

Two new compounds isobenzofuranone A (1) and indandione B (2), together with eleven known compounds (3–13) were isolated from liquid cultures of an endophytic fungus Alternaria sp., which was obtained from the medicinal plant Morinda officinalis. Among them, the indandione (2) showed a rarely occurring indanone skeleton in natural products. Their structures were elucidated mainly on the basis of extensive spectroscopic data analysis. All of the compounds were evaluated with cytotoxic and α-glucosidase inhibitory activity assays. Compounds 11 and 12 showed significant inhibitory activities against four tumor cell lines; MCF-7, HepG-2, NCI-H460 and SF-268, with IC50 values in the range of 1.91–9.67 μM, and compounds 4, 5, 9, 10, 12 and 13 showed excellent inhibitory activities against α-glucosidase with IC50 values in the range of 12.05–166.13 μM.
Electrodeposition of Rhodium Nanowires Arrays and Their Morphology-Dependent Hydrogen Evolution Activity
Authors: Zhang Liqiu , Liu Lichun , Wang Hongdan , Shen Hongxia , Cheng Qiong , Yan Chao , Park Sungho
Published: May 2017

This work reports on the electrodeposition of rhodium (Rh) nanowires with a controlled surface morphology synthesized using an anodic aluminum oxide (AAO) template. Vertically aligned Rh nanowires with a smooth and coarse morphology were successfully deposited by adjusting the electrode potential and the concentration of precursor ions and by involving a complexing reagent in the electrolyte solution. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analyses were used to follow the morphological evolution of Rh nanowires. As a heterogeneous electrocatalyst for hydrogen evolution reactions (HER), the coarse Rh nanowire array exhibited an enhanced catalytic performance respect to smooth ones due to the larger surface area to mass ratio and the higher density of catalytically active defects, as evidenced by voltammetric measurements and TEM. Results suggest that the morphology of metallic nanomaterials could be readily engineered by electrodeposition. The controlled electrodeposition offers great potential for the development of an effective synthesis tool for heterogeneous catalysts with a superior performance for wide applications.
Attenuating the Biologic Drive for Weight Regain Following Weight Loss: Must What Goes Down Always Go Back Up?
Authors: Melby Christopher , Paris Hunter , Foright Rebecca , Peth James
Published: May 2017

Metabolic adaptations occur with weight loss that result in increased hunger with discordant simultaneous reductions in energy requirements—producing the so-called energy gap in which more energy is desired than is required. The increased hunger is associated with elevation of the orexigenic hormone ghrelin and decrements in anorexigenic hormones. The lower total daily energy expenditure with diet-induced weight loss results from (1) a disproportionately greater decrease in circulating leptin and resting metabolic rate (RMR) than would be predicted based on the decline in body mass, (2) decreased thermic effect of food (TEF), and (3) increased energy efficiency at work intensities characteristic of activities of daily living. These metabolic adaptations can readily promote weight regain. While more experimental research is needed to identify effective strategies to narrow the energy gap and attenuate weight regain, some factors contributing to long-term weight loss maintenance have been identified. Less hunger and greater satiation have been associated with higher intakes of protein and dietary fiber, and lower glycemic load diets. High levels of physical activity are characteristic of most successful weight maintainers. A high energy flux state characterized by high daily energy expenditure and matching energy intake may attenuate the declines in RMR and TEF, and may also result in more accurate regulation of energy intake to match daily energy expenditure.
Psychometric Properties of a Developed Questionnaire to Assess Knowledge, Attitude and Practice Regarding Vitamin D (D-KAP-38)
Authors: Amiri Parisa , Asghari Golaleh , Sadrosadat Hoda , Karimi Mehrdad , Amouzegar Atieh , Mirmiran Parvin , Azizi Fereidoun
Published: May 2017

The aim of this study was to develop a valid and reliable questionnaire to assess vitamin D-related knowledge, attitude and practices in Tehranian adults, who may be at increased risk of vitamin D deficiency. This study was conducted on 572 individuals, aged ≥20 years from public health care centers in Tehran, Iran. Based on results of a literature review and in-depth interviews, the 38-item vitamin D-related KAP questionnaire (D-KAP-38) with four subscales was developed: (1) general knowledge; (2) nutritional knowledge; (3) attitudes; (4) behaviors. Validity of the D-KAP-38 questionnaire was assessed, utilizing face, content, and construct validity methods. Internal consistency was calculated to assess reliability of the current developed questionnaire. A total of 572 (54.1% female) adults, aged 30.2 ± 7.9 years, participated in the study. All items were perceived as relevant and comprehendible by participants. Content validity was confirmed by a panel of experts. The internal consistency, as measured by Cronbach’s alpha coefficients, exceeded the minimum reliability standard of 0.60 for four subscales. Exploratory factor analysis suggested a four-factor construct and the results of the confirmatory factor analysis indicated acceptable fit indices for the proposed model. No ceiling effects were observed except for general knowledge (1.2%). Floor effects detected were 0%, 1.1%, 2.4%, and 8.7% for practice, attitude, general knowledge, and nutrition knowledge, respectively. General knowledge had the highest score (79.59 ± 14.52) and nutrition knowledge had the lowest (42.58 ± 20.40), among the four sub-scales. Results confirm the initial validity and reliability of D-KAP-38 questionnaire. Further investigations in different populations are recommended.
A Software-Defined GNSS Reflectometry Recording Receiver with Wide-Bandwidth, Multi-Band Capability and Digital Beam-Forming
Authors: Ribó Serni , Arco-Fernández Juan , Cardellach Estel , Fabra Fran , Li Weiqiang , Nogués-Correig Oleguer , Rius Antonio , Martín-Neira Manuel
Published: May 2017

In this paper, we present the Software PARIS Interferometric Receiver (SPIR), a high-speed GNSS reflectometry recording receiver which has been designed and implemented with the primary goal of demonstrating the synoptic capabilities of the interferometric technique in GNSS Reflectrometry. Thanks to the use of large bandwidth GNSS signals, this technique is advantageous in comparison to the so-called clean-replica processing, when sea surface altimetric applications are pursued. The SPIR receiver down-converts, samples, and records the GNSS signals acquired by the sixteen elements of two antenna arrays. It can operate at any of the common GNSS L1, L2, or L5 bands. Digital beam-forming and signal processing is performed off-line by its dedicated signal processor, so that the GNSS reflectometry can be applied to different transmitting satellites using the same set of recorded signals. Alternatively, different processing techniques can be compared by applying them to exactly the same signals. This article focuses on the SPIR instrument hardware and software, as well as the remote sensing observables that can be obtained using this equipment.
Comparative Assessment of Two Vegetation Fractional Cover Estimating Methods and Their Impacts on Modeling Urban Latent Heat Flux Using Landsat Imagery
Authors: Liu Kai , Su Hongbo , Li Xueke
Published: May 2017

Quantifying vegetation fractional cover (VFC) and assessing its role in heat fluxes modeling using medium resolution remotely sensed data has received less attention than it deserves in heterogeneous urban regions. This study examined two approaches (Normalized Difference Vegetation Index (NDVI)-derived and Multiple Endmember Spectral Mixture Analysis (MESMA)-derived methods) that are commonly used to map VFC based on Landsat imagery, in modeling surface heat fluxes in urban landscape. For this purpose, two different heat flux models, Two-source energy balance (TSEB) model and Pixel Component Arranging and Comparing Algorithm (PCACA) model, were adopted for model evaluation and analysis. A comparative analysis of the NDVI-derived and MESMA-derived VFCs showed that the latter achieved more accurate estimates in complex urban regions. When the two sources of VFCs were used as inputs to both TSEB and PCACA models, MESMA-derived urban VFC produced more accurate urban heat fluxes (Bowen ratio and latent heat flux) relative to NDVI-derived urban VFC. Moreover, our study demonstrated that Landsat imagery-retrieved VFC exhibited greater uncertainty in obtaining urban heat fluxes for the TSEB model than for the PCACA model.
Screening Genotoxicity Chemistry with Microfluidic Electrochemiluminescent Arrays
Authors: Bist Itti , Bano Kiran , Rusling James
Published: May 2017

This review describes progress in the development of electrochemiluminescent (ECL) arrays aimed at sensing DNA damage to identify genotoxic chemistry related to reactive metabolites. Genotoxicity refers to chemical or photochemical processes that damage DNA with toxic consequences. Our arrays feature DNA/enzyme films that form reactive metabolites of test chemicals that can subsequently react with DNA, thus enabling prediction of genotoxic chemical reactions. These high-throughput ECL arrays incorporating representative cohorts of human metabolic enzymes provide a platform for determining chemical toxicity profiles of new drug and environmental chemical candidates. The arrays can be designed to identify enzymes and enzyme cascades that produce the reactive metabolites. We also describe ECL arrays that detect oxidative DNA damage caused by metabolite-mediated reactive oxygen species. These approaches provide valuable high-throughput tools to complement modern toxicity bioassays and provide a more complete toxicity prediction for drug and chemical product development.
A Versatile Electronic Tongue Based on Surface Plasmon Resonance Imaging and Cross-Reactive Sensor Arrays—A Mini-Review
Authors: Garçon Laurie-Amandine , Genua Maria , Hou Yanjie , Buhot Arnaud , Calemczuk Roberto , Livache Thierry , Billon Martial , Le Narvor Christine , Bonnaffé David , Lortat-Jacob Hugues , Hou Yanxia
Published: May 2017

Nowadays, there is a strong demand for the development of new analytical devices with novel performances to improve the quality of our daily lives. In this context, multisensor systems such as electronic tongues (eTs) have emerged as promising alternatives. Recently, we have developed a new versatile eT system by coupling surface plasmon resonance imaging (SPRi) with cross-reactive sensor arrays. In order to largely simplify the preparation of sensing materials with a great diversity, an innovative combinatorial approach was proposed by combining and mixing a small number of easily accessible molecules displaying different physicochemical properties. The obtained eT was able to generate 2D continuous evolution profile (CEP) and 3D continuous evolution landscape (CEL), which is also called 3D image, with valuable kinetic information, for the discrimination and classification of samples. Here, diverse applications of such a versatile eT have been summarized. It is not only effective for pure protein analysis, capable of differentiating protein isoforms such as chemokines CXCL12α and CXCL12γ, but can also be generalized for the analysis of complex mixtures, such as milk samples, with promising potential for monitoring the deterioration of milk.
Full-Field Calibration of Color Camera Chromatic Aberration using Absolute Phase Maps
Authors: Liu Xiaohong , Huang Shujun , Zhang Zonghua , Gao Feng , Jiang Xiangqian
Published: May 2017

The refractive index of a lens varies for different wavelengths of light, and thus the same incident light with different wavelengths has different outgoing light. This characteristic of lenses causes images captured by a color camera to display chromatic aberration (CA), which seriously reduces image quality. Based on an analysis of the distribution of CA, a full-field calibration method based on absolute phase maps is proposed in this paper. Red, green, and blue closed sinusoidal fringe patterns are generated, consecutively displayed on an LCD (liquid crystal display), and captured by a color camera from the front viewpoint. The phase information of each color fringe is obtained using a four-step phase-shifting algorithm and optimum fringe number selection method. CA causes the unwrapped phase of the three channels to differ. These pixel deviations can be computed by comparing the unwrapped phase data of the red, blue, and green channels in polar coordinates. CA calibration is accomplished in Cartesian coordinates. The systematic errors introduced by the LCD are analyzed and corrected. Simulated results show the validity of the proposed method and experimental results demonstrate that the proposed full-field calibration method based on absolute phase maps will be useful for practical software-based CA calibration.
Alternative Path Communication in Wide-Scale Cluster-Tree Wireless Sensor Networks Using Inactive Periods
Authors: Leão Erico , Montez Carlos , Moraes Ricardo , Portugal Paulo , Vasques Francisco
Published: May 2017

The IEEE 802.15.4/ZigBee cluster-tree topology is a suitable technology to deploy wide-scale Wireless Sensor Networks (WSNs). These networks are usually designed to support convergecast traffic, where all communication paths go through the PAN (Personal Area Network) coordinator. Nevertheless, peer-to-peer communication relationships may be also required for different types of WSN applications. That is the typical case of sensor and actuator networks, where local control loops must be closed using a reduced number of communication hops. The use of communication schemes optimised just for the support of convergecast traffic may result in higher network congestion and in a potentially higher number of communication hops. Within this context, this paper proposes an Alternative-Route Definition (ARounD) communication scheme for WSNs. The underlying idea of ARounD is to setup alternative communication paths between specific source and destination nodes, avoiding congested cluster-tree paths. These alternative paths consider shorter inter-cluster paths, using a set of intermediate nodes to relay messages during their inactive periods in the cluster-tree network. Simulation results show that the ARounD communication scheme can significantly decrease the end-to-end communication delay, when compared to the use of standard cluster-tree communication schemes. Moreover, the ARounD communication scheme is able to reduce the network congestion around the PAN coordinator, enabling the reduction of the number of message drops due to queue overflows in the cluster-tree network.
Spectrum Sensing Using Co-Prime Array Based Modulated Wideband Converter
Authors: Lv Wanghan , Wang Huali , Mu Shanxiang
Published: May 2017

As known to us all, it is challenging to monitor wideband signals in frequency domain due to the restriction of hardware. Several practical sampling schemes, such as multicoset sampling and the modulated wideband converter (MWC), have been proposed. In this work, a co-prime array (CA) based modulated wideband converter (MWC) spectrum sensing method is suggested. Our proposed method has the same sampling principle as the MWC but has some advantages compared to MWC. Firstly, CA-based MWC is an array-based MWC system. Each sensor is usually corrupted by independent noise for an array system which can be used for noise averaging, while all channels in conventional MWC have the same receiving noise. Secondly, by incorporating the co-prime array, we can estimate the power spectrum of signal directly employing its second-order statistical properties. Moreover, the system minimal sampling rate can be reduced further because of the reduction of sampling channels. Simulation results show that our method has better performance than traditional methods.
Characterizing Esophageal Cancerous Cells at Different Stages Using the Dielectrophoretic Impedance Measurement Method in a Microchip
Authors: Wang Hsiang-Chen , Nguyen Ngoc-Viet , Lin Rui-Yi , Jen Chun-Ping
Published: May 2017

Analysis of cancerous cells allows us to provide useful information for the early diagnosis of cancer and to monitor treatment progress. An approach based on electrical principles has recently become an attractive technique. This study presents a microdevice that utilizes a dielectrophoretic impedance measurement method for the identification of cancerous cells. The proposed biochip consists of circle-on-line microelectrodes that are patterned using a standard microfabrication processes. A sample of various cell concentrations was introduced in an open-top microchamber. The target cells were collectively concentrated between the microelectrodes using dielectrophoresis manipulation, and their electrical impedance properties were also measured. Different stages of human esophageal squamous cell carcinoma lines could be distinguished. This result is consistent with findings using hyperspectral imaging technology. Moreover, it was observed that the distinguishing characteristics change in response to the progression of cancer cell invasiveness by Raman spectroscopy. The device enables highly efficient cell collection and provides rapid, sensitive, and label-free electrical measurements of cancerous cells.
Smartphone-Based Escalator Recognition for the Visually Impaired
Authors: Nakamura Daiki , Takizawa Hotaka , Aoyagi Mayumi , Ezaki Nobuo , Mizuno Shinji
Published: May 2017

It is difficult for visually impaired individuals to recognize escalators in everyday environments. If the individuals ride on escalators in the wrong direction, they will stumble on the steps. This paper proposes a novel method to assist visually impaired individuals in finding available escalators by the use of smartphone cameras. Escalators are recognized by analyzing optical flows in video frames captured by the cameras, and auditory feedback is provided to the individuals. The proposed method was implemented on an Android smartphone and applied to actual escalator scenes. The experimental results demonstrate that the proposed method is promising for helping visually impaired individuals use escalators.
Obstacle Detection and Avoidance System Based on Monocular Camera and Size Expansion Algorithm for UAVs
Authors: Al-Kaff Abdulla , García Fernando , Martín David , De La Escalera Arturo , Armingol José
Published: May 2017

One of the most challenging problems in the domain of autonomous aerial vehicles is the designing of a robust real-time obstacle detection and avoidance system. This problem is complex, especially for the micro and small aerial vehicles, that is due to the Size, Weight and Power (SWaP) constraints. Therefore, using lightweight sensors (i.e., Digital camera) can be the best choice comparing with other sensors; such as laser or radar.For real-time applications, different works are based on stereo cameras in order to obtain a 3D model of the obstacles, or to estimate their depth. Instead, in this paper, a method that mimics the human behavior of detecting the collision state of the approaching obstacles using monocular camera is proposed. The key of the proposed algorithm is to analyze the size changes of the detected feature points, combined with the expansion ratios of the convex hull constructed around the detected feature points from consecutive frames. During the Aerial Vehicle (UAV) motion, the detection algorithm estimates the changes in the size of the area of the approaching obstacles. First, the method detects the feature points of the obstacles, then extracts the obstacles that have the probability of getting close toward the UAV. Secondly, by comparing the area ratio of the obstacle and the position of the UAV, the method decides if the detected obstacle may cause a collision. Finally, by estimating the obstacle 2D position in the image and combining with the tracked waypoints, the UAV performs the avoidance maneuver. The proposed algorithm was evaluated by performing real indoor and outdoor flights, and the obtained results show the accuracy of the proposed algorithm compared with other related works.
A Method of Sky Ripple Residual Nonuniformity Reduction for a Cooled Infrared Imager and Hardware Implementation
Authors: Li Yiyang , Jin Weiqi , Li Shuo , Zhang Xu , Zhu Jin
Published: May 2017

Cooled infrared detector arrays always suffer from undesired ripple residual nonuniformity (RNU) in sky scene observations. The ripple residual nonuniformity seriously affects the imaging quality, especially for small target detection. It is difficult to eliminate it using the calibration-based techniques and the current scene-based nonuniformity algorithms. In this paper, we present a modified temporal high-pass nonuniformity correction algorithm using fuzzy scene classification. The fuzzy scene classification is designed to control the correction threshold so that the algorithm can remove ripple RNU without degrading the scene details. We test the algorithm on a real infrared sequence by comparing it to several well-established methods. The result shows that the algorithm has obvious advantages compared with the tested methods in terms of detail conservation and convergence speed for ripple RNU correction. Furthermore, we display our architecture with a prototype built on a Xilinx Virtex-5 XC5VLX50T field-programmable gate array (FPGA), which has two advantages: (1) low resources consumption; and (2) small hardware delay (less than 10 image rows). It has been successfully applied in an actual system.
Gendered Perceptions of Cultural and Skill Alignment in Technology Companies
Authors: Wynn Alison , Correll Shelley
Published: May 2017

Previous research documents how stereotypes discourage young women from choosing and attaining technology jobs. We build off this research and ask whether (and how) stereotypes continue to affect men and women once they enter the technology workforce. Using a novel survey of technical employees from seven Silicon Valley firms and new measures of what we call “cultural” and “skill” alignment, we show that men are more likely than women to believe they possess the stereotypical traits and skills of a successful tech employee. We find that cultural alignment is especially important: because women are less likely than men to believe they match the cultural image of successful tech workers, they are less likely to identify with the tech profession, less likely to report positive supervisor treatment, and more likely to consider switching career fields. This paper is the first to use unique and independent measures of cultural and skill alignment comparing employees’ perceptions of themselves to their perceptions of an ideal successful worker. By allowing cultural and skill alignment to operate separately, we are able to determine which work outcomes are most strongly related to each form of alignment. Our results imply that if we can broaden the cultural image of a successful tech worker, women may be more likely to feel like they belong in technology environments, ultimately increasing their retention in tech jobs.
Floodplain Stability Indices for Sustainable Waterfront Development by Spatial Identification of Erosion and Deposition
Authors: Song Chang , Ku Tae , Kim Young , Park Yong
Published: May 2017

The abrupt rises of water level in rivers by torrential rain or storm repeatedly cause inundation damage, such as erosion and deposition in floodplains. However, studies on identifying the abrasion of waterfront facilities or the accumulation of sediment near rivers under extreme flow conditions are seldom found because floodplains are utilized in various ways in each country. In this study, novel floodplain sustainability indices by spatial classification of erosion and deposition were developed for sustainable waterfront development. The indices can provide the relative spatial distribution of erosion and deposition in a floodplain by using only kinematic flow information, such as flow depth and velocity obtained by 2D numerical analysis. Accordingly, applying a complex sediment transport model that involves numerous assumptions and parameters can be moderately replaced with the present approach. The suitability of developed indices was tested in several flow problems by comparing the predicted erosional or depositional region with measured data. In addition, the developed indices were applied to a floodplain in a natural river to examine the relative spatial distribution of the erosion and deposition for a typhoon event, and the results were compared with field monitoring data. It was found that deposition was more likely to occur than erosion in most floodplains, and the developed floodplain sustainability indices accurately quantified the erosion and deposition phenomena.
Monitoring Spatial Patterns and Changes of Ecology, Production, and Living Land in Chinese Urban Agglomerations: 35 Years after Reform and Opening Up, Where, How and Why?
Authors: Cao Shisong , Hu Deyong , Zhao Wenji , Mo You , Chen Shanshan
Published: May 2017

Chinese urban agglomeration (UA) has gradually become a new world economic center and the strategic region of the “The Belt and Road Initiatives”. The spatial patterns and variations of ecology–production–living land (EPL) profoundly affect UA’s development and its ecological environment. Unfortunately, scientific understanding about the trajectories, patterns and drivers of EPL changes in Chinese urban agglomerations (UAs) since reform and opening up is still very limited. The aim of this paper was to monitor those characteristics during the last 35 years. Here, we proposed a new classification system of EPL, including ecology land (EL), industrial production land (IPL), agricultural production land (APL), urban living land (ULL) and rural living land (RLL) due to Chinese urban–rural dual structure. Then, we extracted EPL land from the Chinese LUCC product, which is the recently released remote sensing data product of high resolution spatial land use data in China at national level. Furthermore, we analyzed the spatial-temporal trajectories and driving factors of EPL for Chinese UAs during 1980–2015. The results showed that: (1) ULL and IPL in Chinese UAs were increased rapidly, while EL and APL were seriously decreased. (2) The growth patterns of ULL and IPL had shown a spatial heterogeneity. As to different regional UAs, the expansion rates of ULL and IPL ranked from high to low were as follows: eastern, central, western, and northeastern UAs. (3) National policies, population, and economy dominated the spatial-temporal changes of EPL in Chinese UAs. (4) The multi-planning integration in the structure of land use should be strengthened at UA-scale.
Virtual Inertia Control-Based Model Predictive Control for Microgrid Frequency Stabilization Considering High Renewable Energy Integration
Authors: Kerdphol Thongchart , Rahman Fathin , Mitani Yasunori , Hongesombut Komsan , Küfeoğlu Sinan
Published: May 2017

Renewable energy sources (RESs), such as wind and solar generations, equip inverters to connect to the microgrids. These inverters do not have any rotating mass, thus lowering the overall system inertia. This low system inertia issue could affect the microgrid stability and resiliency in the situation of uncertainties. Today’s microgrids will become unstable if the capacity of RESs become larger and larger, leading to the weakening of microgrid stability and resilience. This paper addresses a new concept of a microgrid control incorporating a virtual inertia system based on the model predictive control (MPC) to emulate virtual inertia into the microgrid control loop, thus stabilizing microgrid frequency during high penetration of RESs. The additional controller of virtual inertia is applied to the microgrid, employing MPC with virtual inertia response. System modeling and simulations are carried out using MATLAB/Simulink® software. The simulation results confirm the superior robustness and frequency stabilization effect of the proposed MPC-based virtual inertia control in comparison to the fuzzy logic system and conventional virtual inertia control in a system with high integration of RESs. The proposed MPC-based virtual inertia control is able to improve the robustness and frequency stabilization of the microgrid effectively.
Laser Treatment on Acupuncture Points Improves Pain and Wrist Functionality in Patients Undergoing Rehabilitation Therapy after Wrist Bone Fracture. A Randomized, Controlled, Blinded Study
Authors: Acosta-Olivo Carlos , Siller-Adame Ana , Tamez-Mata Yadira , Vilchez-Cavazos Felix , Peña-Martinez Victor
Published: May 2017

The objective of this study was to determine whether application of laser beam on acupuncture points has a positive effect on the rehabilitation of patients with a diagnosis of distal radius fracture (1.5 inches proximal to distal articular surface of the radius) when applied with active
conventional physical therapy exercises. Patients with a distal radius fracture treated with closed reduction, percutaneous pinning, and a short cast for six weeks was included and were assigned to one of two study groups. The control group was given simulated laser acupuncture with the laser
off, while the experimental group received laser beam on acupuncture points. A low power infrared 980 nm, 50 mW laser (Diller & Diller Laser Performance) electric energy, was used; each acupuncture point was irradiated for 30 seconds at 8,000 Hz at each therapy session. In both groups,
treatment was applied to the following points: Ipsilateral- Yanggu (SI5), Yangchi (SJ4), Waiguan (SJ15), Yangxi (LI5), Daling (PC7); Bilateral- Hegu (LI4); Contralateral- Shenmail (VL62), Kulun (V60), Taixi (KID3). All of the patients underwent a total of 10 sessions, at a frequency of three
times per week. They were evaluated using the VAS, the Patient-Rated Wrist Evaluation (PRWE), and wrist mobility ranges at the beginning of treatment, at the end of the fifth session, at the 10th session, and a week after the 10th session. The patients treated with laser beam exposure on acupuncture
points showed 44% reduction in pain and 33% of improvement in the functional status of the wrist compared with the control group. Application of laser beam on acupuncture points combined with active rehabilitation exercises show benefits in the rehabilitation of patients with a distal radius
fracture managed with percutaneous pinning and a short cast.
Multigene Expression Profile Testing in Breast Cancer: Is There a Role for Family Physicians?
Authors: O’Brien M.A. , Carroll J.C. , Manca D.P. , Miedema B. , Groome P.A. , Makuwaza T. , Easley J. , Sopcak N. , Jiang L. , Decker K. , McBride M.L. , Moineddin R. , Permaul J.A. , Heisey R. , Eisenhauer E.A. , Krzyzanowska M.K. , Pruthi S. , Sawka C. , Schneider N. , Sussman J. , Urquhart R. , Versaevel C. , Grunfeld E.
Published: May 2017

Background: Family physicians (fps) play a role in aspects of personalized medicine in cancer, including assessment of increased risk because of family history. Little is known about the potential role of fps in supporting cancer patients who undergo tumour gene expression profile (gep) testing. Methods: We conducted a mixed-methods study with qualitative and quantitative components. Qualitative data from focus groups and interviews with fps and cancer specialists about the role of fps in breast cancer gep testing were obtained during studies conducted within the pan-Canadian canimpact research program. We determined the number of visits by breast cancer patients to a fp between the first medical oncology visit and the start of chemotherapy, a period when patients might be considering results of gep testing. Results: The fps and cancer specialists felt that ordering gep tests and explaining the results was the role of the oncologist. A new fp role was identified relating to the fp–patient relationship: supporting patients in making adjuvant therapy decisions informed by gep tests by considering the patient’s comorbid conditions, social situation, and preferences. Lack of fp knowledge and resources, and challenges in fp–oncologist communication were seen as significant barriers to that role. Between 28% and 38% of patients visited a fp between the first oncology visit and the start of chemotherapy. Conclusions: Our findings suggest an emerging role for fps in supporting patients who are making adjuvant treatment decisions after receiving the results of gep testing. For success in this new role, education and point-of-care tools, together with more effective communication strategies between fps and oncologists, are needed.
Systemic Therapy in the Curative Treatment of Head-and-Neck Squamous Cell Cancer: Cancer Care Ontario Clinical Practice Guideline
Authors: Winquist E. , Agbassi C. , Meyers B.M. , Yoo J. , Chan K.K.W.
Published: May 2017

Objective: The aim of the present work was to make recommendations about the use of systemically administered drugs in combination or in sequence with radiation (rt) or surgery, or both, for cure or organ preservation, or both, in patients with locally advanced nonmetastatic (stages iii–ivb) squamous cell carcinoma of the head and neck (lascchn). Methods: The Meta-analysis of Chemotherapy in Head and Neck Cancer (mach-nc) reports have, de facto, guided practice since 2000, and so we searched the literature for systematic reviews published from January 2000 to February 2015 in reference to five research questions. A search was also conducted up to February 2015 for randomized trials (rcts) not included in the meta-analyses. Recommendations were constructed using the Cancer Care Ontario Program in Evidence-Based Care practice guidelines development cycle. Results: In addition to updated mach-nc reports, five additional meta-analyses and thirty rcts were identified. Five recommendations for lascchn treatment were generated based on those data. Concurrent chemoradiation (ccrt) is recommended to maximize the chance of cure in patients less than 71 years of age when rt is used as definitive treatment. The same recommendation also applies to patients with resected lascchn considered to be at high risk for locoregional recurrence. For lascchn patients who are candidates for organ preservation strategies and would otherwise require total laryngectomy, either ccrt or induction chemotherapy, followed by rt or surgery based on tumour response is recommended. The addition of cetuximab to intensified rt (concomitant boost or hyperfractionated schedule) is an alternative to ccrt. Routine use of induction chemotherapy to improve overall survival is not recommended. Conclusions: We were able to use high-level evidence from patients receiving rt as definitive or postoperative treatment to generate recommendations for the use of systemic therapy in the treatment of lascchn. A limitation is a lack of stratification for human papillomavirus–related cancers of the oropharynx. One rct provided evidence for the use of cetuximab as an alternative to chemotherapy in the definitive rt setting. Concurrent chemoradiation provides one strategy for larynx preservation, but the best strategy is unclear. Use of induction chemotherapy does not improve overall survival, and its use should be limited to patients requiring immediate tumour downsizing before local therapy.
On the Origin of Sub-subgiant Stars. II. Binary Mass Transfer, Envelope Stripping, and Magnetic Activity∗
Authors: Leiner Emily , Mathieu Robert D. , Geller Aaron M.
Published: May 2017

Sub-subgiant stars (SSGs) lie to the red of the main sequence and fainter than the red giant branch in cluster color–magnitude diagrams (CMDs), a region not easily populated by standard stellar evolution pathways. While there has been speculation on what mechanisms may create these unusual stars, no well-developed theory exists to explain their origins. Here we discuss three hypotheses of SSG formation: (1) mass transfer in a binary system, (2) stripping of a subgiant’s envelope, perhaps during a dynamical encounter, and (3) reduced luminosity due to magnetic fields that lower convective efficiency and produce large starspots. Using the stellar evolution code MESA, we develop evolutionary tracks for each of these hypotheses, and compare the expected stellar and orbital properties of these models with six known SSGs in the two open clusters M67 and NGC 6791. All three of these mechanisms can create stars or binary systems in the SSG CMD domain. We also calculate the frequency with which each of these mechanisms may create SSG systems, and find that the magnetic field hypothesis is expected to create SSGs with the highest frequency in open clusters. Mass transfer and envelope stripping have lower expected formation frequencies, but may nevertheless create occasional SSGs in open clusters. They may also be important mechanisms to create SSGs in higher mass globular clusters.