bluuebunny/crossref_metadata_2025 huggingface dataset:
The Importance of the Indices in Acceptance or Reject of a Hadiths by Imam Al-Tirmidhi in His Book al-Jami’a (Chosen Examples from Tahara Book)
Authors: Hafidi Hakima , Omara Siham
Published: July 2022

This paper is concerned with examining Imam Al-Tirmidhi’s action in accepting and refuting the narrations, in addition to weighting the differences by relying on the strengthening evidence of one aspect over the other; and other things that we mentioned in the research through selected examples from The Book of Purification “Ettahara”. What prompted us to write on this subject was what was rumoured about Imam al-Tirmidhi that he was lenient regarding discrediting and endorsement and correcting and weakening. And then the need for specialists to clarify this issue. This research used the critical analytical approach, through which we reached some results, the most important of which are: that Imam Al-Tirmidhi relied on various evidence in weighing the differences and in accepting and rejecting. As for the issue of leniency with which al-Tirmidhi was accused, we did not find any mention of it among the imams who preceded him.
The Influence of Quality of Work Life and Islamic Work Ethics Towards Job Performance among SMEs’ Employee
Authors: Rokhman Wahibur , Ahamed Forbis
Published: July 2022

This study aims to scrutinize the contribution of quality of work life and Islamic work ethics to the job performance of employees who work for Small and Medium Enterprises (SMEs) in Central Java, Indonesia. A deductive questionnaire survey approach was applied to make sure data gathering reaches out across business sectors particularly, most of the registered SMEs throughout central Java. About 354 valid responses were analyzed utilizing SPSS in order to be able to examine how much quality work life of employees in the light of ethical values practice in Islam impact the performance of employees. The outcomes of the study revealed a tremendous effect on the performance of employees in SMEs while their work lives are taken cared for by the company. Similarly, performance found to be overwhelmingly determined by work ethics reflexively applied in a densely populated peninsula of Javanese Muslims. This is reconfirmed when IWE predisposed a significant positive relationship with quality of work life. The results of this study, as expected, provide theoretical and practical gains to the body of knowledge as well as become an impetus for all the likewise faith base business communities across the region, particularly for SMEs’ owner/manager and certainly for future researchers.
Digitalization and Efficiency: Technology-based Service of Indonesia Sharia Commercial Banks
Authors: Bella Firsty Izzata , Himmawan M Fikri
Published: July 2022

This study aims to assess the technology-based service effectiveness on bank profitability as well as to evaluate the efficiency and stability of Islamic Commercial Banks in Indonesia. The model was analyzed by using multiple linear regressions with generalized least square estimation technique and Data Envelopment Analysis (DEA) with data are gathered from Q1 2017 to Q2 2020. The exogenous variables included were Branchless Banking (BB), Third-party Funds (DPK), and Technology Service Quality (TSQ), with banking operational income (PENDOP) as endogenous variable. The DEA method analyses the VRS and CRS scale while using output orientation. Using the inputs of DPK, operational expenses, and total funding, with the outputs of operational earnings and total assets. The main finding suggests that DPK played as a dominant variable, following by TSQ and BB on bank operational income. Moreover, the results of the DEA models showed in four quadrants in each CRS and VRS model. Respectively, 1 and 5 banks are highly efficient and stable, 5 and 2 banks have high efficiency but low stability, 4 and 2 banks have low efficiency but high stability, 4 and 5 banks have low efficiency and stability in the CRS and VRS model.
Narrow funnel-like interaction energy distribution is an indicator of specific protein interaction partner.
Authors: Choi Juyoung
Published: July 2022

Protein interaction networks underlie countless biological mechanisms. However, most protein interaction predictions are based on interspecies biological evidence (knowledge-based predictions) that are biased to well-known protein interaction or physical evidence that exhibits low accuracy for weak interactions and requires high computational power. In this study, a novel method has been suggested to predict protein interactions using interaction energy distribution. Protein interactions with specific partners can be predicted by investigating narrow funnel-like interaction energy distribution, exhibiting a stable state in a specific orientation. In this study, it was demonstrated that various protein interactions with specific interaction partner, such as protein interaction with kinase and E3 ubiquitin ligases, have narrow funnel-like interaction energy distribution. Moreover, algorithm and deep learning model for prediction of general protein interaction partner and substrate of kinase and E3 ubiquitin ligase were developed. The prediction accuracy of this method is similar to or even better than that of yeast two-hybrid screening, which is the most widely applied interaction screening method. Ultimately, this knowledge-free protein interaction prediction method will broaden our understanding of protein interaction networks.
Energy Generation Cost Without and With CO2 Capture for Power Plants
Authors: Chavez Rosa-Hilda
Published: July 2022

This work addresses the National Strategic Program on Energy Transition, of the Energy Sector Program 2020–2024, Mexican Energy Ministry. The Energy Transition states, "Reach a level of energy consumption that is sustainable in the long term and that contributes globally to the mitigation of climate change and energy sovereignty." To answer the statement, it is necessary to mitigate the production of CO2, as the main greenhouse gas, constantly emitted by power plants, by the combustion of fossils, and a primary source of energy. The CO2 capture process is energy intensive, so its study and search for the optimization of mass transfer, energy parameters and cost analysis are necessary for its widespread application. In the context of climate change mitigation, CO2 capture and sequestration (CCS), as well as its possible long-term storage, or preferably its use (CCUS), represent a technological route to neutralize CO2 emissions without leaving to use fossil fuels, during a period in which these fuels are replaced or their use rationalized by means of energy efficiency improvement methods. The objective of this work is to analyze the investment in electricity generation without and with CO2 capture process in three power plants in Mexico: Natural Gas Boiler, Open Cycle Natural Gas Turbine Boiler and Coal Boiler. Efficiency and cost results are presented in production by energy use in power plants; as well as experimental and theorical results for the capture of CO2 considering post-combustion technology by chemical absorption, with 30% Monoethanolamine in aqueous solution, and ININ 18 structured packing. With CO2 capture process, it was reduced 9.7%, meaning 596.0 kt/y for for natural gas boilers, 9.8% with 607.5 kt/year captured for gas turbine technology; and 9.9% with 2029 kt/year for coal. For the Energy Transition, by capturing CO2, the costs would increase by 14% with capture, on net power of 153 MW for a natural gas boiler; 4.5%, on 228 MW for the gas turbine boiler; and it is even reduced to 2%, on 302 MW for coal.
UHRF1 is a mediator of KRAS driven oncogenesis in lung adenocarcinoma
Authors: Kostyrko Kaja , Lee Alex , Román Marta , Simpson David , Dinh Phuong , Leung Stanley , Marini Kieren , Kelly Marcus , Broyde Joshua , Califano Andrea , Jackson Peter , Sweet-Cordero Alejandro
Published: July 2022

KRAS is one of the most frequently mutated oncogenes in lung cancer. To identify novel KRAS-specific vulnerabilities, we performed RNAi screens in spheroid cultures of primary tumor cells derived from a mouse model of lung cancer driven by activation of Kras and loss of p53. Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1), an epigenetic regulator involved in DNA methylation, was identified as a gene selectively important for the 3D growth of primary tumor cells derived from this model. Further studies in human lung cancer cell lines confirmed that UHRF1 knock-out selectively impaired sphere growth and induced apoptosis in cells expressing oncogenic KRAS but had minimal effect on KRAS wild type or non-transformed lung cells. To understand its KRAS-specific role, we depleted UHRF1 in KRAS mutant lung cancer cell lines and analyzed genome-wide methylation and gene expression. UHRF1 loss led to global DNA hypomethylation resulting in the upregulation of lung cancer-specific tumor suppressor genes (TSGs). The majority of these TSGs were also overexpressed after KRAS loss, suggesting a mechanistic link between UHRF1 and KRAS-driven oncogenic phenotypes. In vivo, UHRF1 knock-out impaired tumor growth in mouse models of KRAS-driven lung cancer. Finally, analysis of lung cancer patient data revealed that high UHRF1 expression is anti-correlated with TSG expression and predicts worse outcomes for patients with tumors harboring KRAS mutations. These results in human cells and mouse models identify UHRF1 as a KRAS-specific vulnerability and a potential target for therapeutic intervention.
Demonstration of weak measurements, projective measurements, and quantum-to-classical transitions in ultrafast free electron-photon interactions
Authors: Pan Yiming , Cohen Eliahu , Karimi Ebrahim , Gover Avraham , Schönenberger Norbert , Chlouba Tomáš , Wang Kangpeng , Nehemia Saar , Hommelhoff Peter , Kaminer Ido , Aharonov Yakir
Published: July 2022

How does the quantum-to-classical transition of measurement occur? This question is vital for both foundations and applications of quantum mechanics. Here, we develop a new measurement-based framework for characterizing the classical and quantum free electron-photon interactions and then experimentally test it. We first analyze the transition from projective to weak measurement in generic light-matter interactions and show that any classical electron-laser-beam interaction can be represented as an outcome of a weak measurement. In particular, the appearance of classical point-particle acceleration is an example of an amplified weak value resulting from weak measurement. A universal factor, exp(Γ2 /2) , quantifies the measurement regimes and their transition from quantum to classical, where Γ corresponds to the ratio between the electron wavepacket size and the optical wavelength. This measurement-based formulation is experimentally verified in both limits of photon-induced near-field electron microscopy and the classical acceleration regime using a dielectric laser accelerator. Our results shed new light on the transition from quantum to classical electrodynamics, enabling to employ the essence of wave-particle duality of both light and electrons in quantum measurement for exploring and applying many quantum and classical light-matter interactions.
An integrated model for examining teachers’ intentions to use augmented reality in science courses
Authors: ates huseyin , garzon juan
Published: July 2022

Many studies show that augmented reality (AR) provides multiple benefits to science education, including learning gains, motivation to learn, and collaborative learning. However, while using AR largely depends on the teachers’ willingness, existing literature lacks studies that identify teachers’ intentions to use this technology. This study proposes a model to predict science teachers’ intentions to use AR in their classes. Our model merges the Theory of Planned Behavior and the Unified Theory of Acceptance and Use of Technology 2. It includes nine hypotheses that were tested with 451 science teachers from different cities in Turkey. The results indicate that our model identifies the factors affecting teachers’ intentions to use AR with a stronger explanatory power than the referenced theories. Besides, all hypotheses within the proposed model were statistically supported in determining antecedents of science teachers' intentions. Finally, the study contributes to the theory and practice by focusing on the psychological aspects required for explaining science teachers’ intentions to use AR.
Directional fabricating of flexible and compressible cellulose nanofibril composite aerogel with excellent thermal insulation, flame-retardancy and radiative cooling for efficient thermal management
Authors: Zhao Jiaojiao , Zhou Jianhua , Li Hong , Xiao Anguo
Published: July 2022

In order to reduce the thermal discomfort and fire accidents caused by overheating of electronics and high temperature of buildings, high-performance thermal insulation and fire-resistant materials are urgently desirable. Cellulose nanofiber aerogel derived from regenerative resources holds wide promise in the field of thermal insulation, but its inherent flammability, poor mechanical strength and water resistance make it face great challenges in practical application. Herein, a lightweight, porous, anisotropic silylated cellulose nanofiber/hydroxylated boron nitride nanosheet (Si-CNF/BNNS) composite aerogel was prepared by unidirectional freeze-casting technique. Attributed to the aligned structure, Si-CNF/BNNS aerogel was robust axially and compressible radially. The thermal conductivity of aerogel was 0.0621 W·m−1·K−1 in the axial direction and 0.0339 W·m−1·K−1 in the radial direction, demonstrating an anisotropic thermal insulation performance. In addition, aerogel also exhibited excellent flame retardant, hydrophobic and radiative cooling properties, as evidenced by extremely low peak heat release rate of 14.05 kW/m2, water contact angle of 136.6° and high solar reflectivity. This high-performance anisotropic Si-CNF/BNNS aerogel is promising in improving thermal comfort and environmental safety, showing its great potential in electronic packaging and energy efficient buildings.
Storm surges during IANOS Medicane
Authors: Androulidakis Yannis , Makris Christos , Mallios Zissis , Pytharoulis Ioannis , Baltikas Vassilis , Krestenitis Yannis
Published: July 2022

The IANOS Medicane was one the most severe storms that have formed in the Mediterranean Sea with Category 2 Hurricane characteristics. The storm induced a significant increase of sea level elevation along its pathway and caused the occurrence of storm surges at the central Ionian Sea with consequent impacts on coastal regions of the Ionian islands and western Greece. A multi-platform approach, based on hydrodynamic ocean simulations, nested to meteorological and coastal flooding simulations, is used in combination with field and satellite observations to describe the marine weather conditions, the storm surge characteristics, and the coastal inundation processes due to the impact of IANOS Medicane in September 2020. Both wind and atmospheric pressure patterns affected the storm surge variability over the Ionian Sea. The direct intrusion of the Medicane from the central Mediterranean Sea towards the Ionian Sea formed storm surges over several coastal areas, even before the storm's landfall, due to the accompanying onshore currents. Storm surges in the order of 30 cm generated extensive flooding over lowland coastal areas, as confirmed by both satellite (Normalized Difference Water Index: NDWI) and numerical (coastal inundation modeling) data. Satellite-derived and simulated estimations showed that, in specific coastal regions, the run-up of seawater extended up to 200 m inland, depending on the hydraulic connectivity between the lowland areas, which determined the inundation extents during the storm surge.
Characterisation of Patients Referred to a Tertiary-Level Inherited Cardiac Condition Clinic with Suspected Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
Authors: Aljehani A , Kew T , Baig S , Cox H , LC Sommerfeld , Ensam B , Kalla M , RP Steeds , Fabritz L
Published: July 2022

BackgroundArrhythmogenic right ventricular cardiomyopathy (ARVC) or arrhythmogenic cardiomyopathy is a rare inherited disease with incomplete penetrance and an environmental component. As ARVC is a common cause of sudden cardiac death in young adults, which can be the first symptom, recognition of early ARVC is important. Data on the different stages of ARVC remains scarce. The purpose of this study is to describe the initial presentation and cardiac phenotype of early and definite ARVC for patients seen at a tertiary service.MethodsThis is a single centre, observational cohort study of patients with early and definite ARVC seen at the Inherited Cardiac Conditions services at University Hospital Birmingham (UHB) in the period 2010–2021. Patients were identified by interrogation of digital health records, medical history, imaging and by examining 12-lead electrocardiograms (ECG).ResultThe records of 1451 patients were reviewed; of those, 165 patients were at risk of ARVC (mean age 41 ± 17 years, 56% male). 60 patients fulfilled task force criteria for definite ARVC diagnosis (n = 40, 67% males), and 37 (71%) of them carried a known pathogenic variant. The remaining 105 patients (50% males) showed early features, and of these 45 (63%) carried a known pathogenic variant. Patients in the definite group were more symptomatic, with palpitations (57% vs. 17%), syncope (35% vs. 6%) and shortness of breath (28% vs. 5%, p < 0.001). T-wave inversion in V1-V3 and epsilon waves were observed only in the definite group. Both PR interval and QRS duration were longer in the definite (170 ± 34 ms and 100 ± 19 ms, p < 0.001) compared to (149 ± 25 and 91 ± 14 ms, p = 0.005). Patients with definite ARVC had significantly larger RV end diastolic areas and significantly reduced biventricular function (RVEDA = 27 ± 10 cm2, RVFAC = 37 ± 11% and EF = 56 ± 12%) compared to the early group (RVEDA = 18 ± 4 cm2, RVFAC 49 ± 6% and LVEF 64 ± 7%, p < 0.001). Sustained ventricular tachycardia (VT) occurred more frequently in the definite group compared to the early group (27% vs. 2%, p < 0.001). Ventricular fibrillation was observed in the definite group only (8 of 60 patients, 13%).ConclusionAlthough definite ARVC patients showed more electrical and structural changes and major adverse cardiac events, some ARVC patients classified as having early ARVC experienced sustained VT. Improving screening methodology is necessary to identify the group most at risk in the future.
Prediction of climate change effects on Siberian Crane (Grus leucogeranus ) habitat suitability by using ensemble modeling in Asia Wetlands
Authors: ansari amir
Published: July 2022

The Siberian Crane (Grus leucogeranus) is the third rarest and the most endangered crane species in the world. This study aimed at predicting the effect of climate change on Siberian Crane habitat suitability of breeding range and wintering range in Asia Wetlands by using ensemble modeling under future climate scenarios before the year 2050. In this regard, we used 4 modeling methods, Surface Range Envelop (SRE), Random Forest (RF), Classification Tree Analysis (CTA) and Flexible Discriminant Analysis (FDA) to determine the relationships between the species occurrence and bioclimatic variables under the ensemble framework by using Biomod2 and R software. The results showed that the AUC values were greater than 0.9 and functioning of all models was excellent. The Temperature Seasonality and Temperature Annual Range in the breeding range and Temperature Seasonality and Mean Temperature of Coldest Quarter in the wintering range had the most important role for habitat suitability of this species and respectively 101.07% and 136.27% changes was justified in Siberian Crane habitat suitability. Under RCP2.6 and RCP8.5 climate scenario for Siberian Crane breeding and wintering range, it is possible that climate change will cause a 100% loss of suitable habitat in West Sibera, and a 25.28% loss in Iran and China by 2050. The results of this study can be used in planning and conservation of crane species.
The spatial distribution of soluble organic matter and its relationship to minerals in the asteroid (162173) Ryugu.
Authors: Hashiguchi Minako , Aoki Dan , Fukushima Kazuhiko , Naraoka Hiroshi , Takano Yoshinori , Jason Dworkin P. , Jose Aponte C. , Jamie Elsila E. , John Eiler M. , Furukawa Yoshihiro , Furusho Aogu , Daniel Glavin P. , Graham Heather V. , Hamase Kenji , Norbert Hertkorn , Isa Junko , Koga Toshiki , Hannah McLain L. , Mita Hajime , Oba Yasuhiro , Ogawa Nanako O. , Ohkouchi Naohiko , Orthous-Daunay Francois-Regis , Parker Eric T. , Alexander Ruf , Sakaki Saburo , Philippe Schmitt-Kopplin , Sugahara Haruna , Roland Thissen , Véronique Vuitton , Wolters Cédric , Yoshimura Toshihiro , Yurimoto Hisayoshi , Nakamura Tomoki , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Sakamoto Kanako , Tachibana Shogo , Yada Toru , Nishimura Masahiro , Nakato Aiko , Miyazaki Akiko , Yogata Kasumi , Abe Masanao , Usui Tomohiro , Yoshikawa Makoto , Saiki Takanao , Tanaka Satoshi , Terui Fuyuto , Nakazawa Satoru , Watanabe Sei-ichiro , Tsuda Yuichi
Published: July 2022

We performed in-situ analysis on a ~1 mm-sized Ryugu grain A0080 returned by the Hayabusa2 spacecraft to investigate the relationship of soluble organic matter (SOM) to minerals. The DESI-HRMS (desorption electrospray ionization-high resolution mass spectrometry) imaging using methanol spray identified more than 200 soluble organic compounds, which were assigned as CHN, CHO, CHO-Na (sodium adducted), and CHNO in molecular composition. Heterogeneous spatial distribution was observed for different compound classes of SOM as well as among the same alkylated homologues on the sample surface. The A0080 sample showed similar mineralogy to that of CI chondrite and contained two different lithologies, which are rich in magnetite, pyrrhotite, and dolomite (lithology 1) and poor in those minerals (lithology 2). CHN compounds were relatively concentrated in lithology 1 than in lithology 2, on the other hand, CHO, CHO-Na, and CHNO compounds were distributed in both lithologies. Such different spatial distribution of SOM is the result of interaction of the SOM with minerals, during precipitation of the SOM via fluid activity, or could be due to difference in transportation efficiencies of SOMs in aqueous fluid. However, organic-related ions measured by ToF-SIMS did not coincide with the spatial distribution revealed by DESI-HRMS imaging, indicating that the ToF-SIMS data would be mainly derived from methanol-insoluble organic matter in A0080. Alkylated homologues of CHN compounds with large C number appeared more abundant in lithology 2 than lithology 1. In contrast, fragments of the Murchison meteorite showed different features to of A0080, implying different formation or growth mechanisms for the alkylated CHN compounds by interaction with fluid and minerals on Murchison parent body and asteroid Ryugu. This difference might be mainly attributed to the carbonate grains, which would have played as a catalyst for CH2 growth of CHN compounds. Future in-situ analysis of CI chondrite will provide more reliable constraints for the history of soluble organic compounds in asteroid Ryugu.
Earthquake and Rainfall Induced Landslide Hazard Assessment of Kutupalong Rohingya Camp Using Meteorological and Geological Information
Authors: Samm-A Anika , Kamal A. S. M. Maksud , Rahman Md. Zillur
Published: July 2022

The study aims to assess the landslide hazard scenario of the Kutupalong Rohingya camp, considered one of the largest humanitarian shelters for conflict-fled people. The camp area lying in a prominent tectonic setting and meteorological environment, is vulnerable to landslide hazards, specifically in the monsoon season. The worst-case scenario of earthquake and rainfall occurrence at the same time or one after another is considered in this study. Landslide favorable parameters (topographic, soil physical property, and contributing factors) are designed in the study to identify the hazard-prone areas through the factor of safety computation. Topographic parameters are prepared by combining field investigation and remote sensing-based information. Soil physical properties are designed in two different models to account for their uncertainties; normal probabilistic distribution and interpolation-based spatial distribution. The contributing factors (earthquake and rainfall) have been assessed using the probabilistic approach. The Peak Ground Acceleration (PGA) exceedance and rainfall intensities of 50, 75, 100, 200, and 475 years return period are applied in the factor of safety calculation. The factor of safety calculation has been run using two different methods; Monte-Carlo simulation using Python scripts and direct estimation method. Different duration (rainfall intensity) scenarios are also modeled to estimate the vulnerable areas in these models. The findings of the study are finally validated against field investigation-based landslide inventory with more than 84% accuracy at a 90% confidence interval.
UBE2E2-induced p62 overexpression promotes Snail-mediated epithelial-mesenchymal transition and metastasis in ovarian cancer
Authors: Hong Xiaoling , Ma Ning , Li Danjie , Zhang Mengwen , Dong Wenqiuzi , Huang Jie , Ci Xinxin , Zhang Songling
Published: July 2022

Dissemination of ovarian cancer (OvCa) cells can lead to inoperable metastatic lesions in the bowel and omentum, which have a poor prognosis despite surgical and chemotherapeutical options. A better understanding of the mechanisms underlying metastasis is urgently needed. In this study, bioinformatics analyses revealed that UBE2E2, a less-studied ubiquitin (Ub)-conjugating enzyme (E2), was upregulated in OvCa and was associated with poor prognosis. Subsequently, we performed western blot analysis and IHC staining with 26 HGSOC and 26 normal ovarian tissue samples, which further confirmed that UBE2E2 protein is highly expressed in OvCa tissue but almost not expressed in normal tissue. Furthermore, the silencing of UBE2E2 blocked OvCa cell migration, epithelial-mesenchymal transition (EMT) and metastasis in vitro, whereas UBE2E2 overexpression exerted the opposite effects. Mechanistically, UBE2E2 promoted p62 accumulation and increased the activity of the Nrf2-antioxidant response element (ARE) system, which ultimately activated the Snail signaling pathway by inhibiting the ubiquitin-mediated degradation of Snail. Furthermore, our results confirmed that mutations in the active site cysteine (Cys139) impaired both the function and cellular distribution of UBE2E2. More importantly, the deletion of UBE2E2 reduced tumorigenicity and metastasis in a xenograft ovarian cancer mouse model. Taken together, our study findings reveal the role of the UBE2E2-Nrf2-p62-Snail signaling axis in OvCa and thus provides novel therapeutic targets for the prevention of metastasis in OvCa.
Association between Nutrient Patterns and Hyperuricemia: Mediation Analysis Involving Obesity Indicators for NHANES study
Authors: Wang Juping , Chen Shuting , Zhao Junkang , Liang Jie , Gao Xue , Gao Qian , He Simin , Wang Tong
Published: July 2022

Background: Diet had long been hypothesized to play an important role in hyperuricemia and weight gain was the stronger factor associated with the rise in serum urate. We aim to clarify the mediating role of obesity in the relationship between diet and hyperuricemia and further determine whether the weight-loss diet is an effective way to prevent hyperuricemia. Methods: This cross-sectional study analyzed representative samples of the United States (n=20081; NHANES 2007-2016) adults. Nutrient patterns were derived with two methods: principal component analysis (PCA) and reduced rank regression (RRR) with obesity. Logistic regression and multivariable linear regression were applied to analyze the association between nutrient patterns in obesity and hyperuricemia. Mediation analyses were used to determine if four obesity indicators, including body mass index (BMI), waist circumference (WC), visceral adiposity index (VAI) and lipid accumulation product Index (LAP), mediated nutrient patterns and hyperuricemia relationship. Results: PCA revealed three nutrient patterns (including “low energy diet”, “lower vitamin A, C, K pattern” and “vitamin B group”) and only vitamin B group had a total effect on hyperuricemia. RRR resulted in one main nutrient pattern associated with obesity, which is characterized by high fat and low vitamin levels and was significantly associated with hyperuricemia. Mediation analysis showed that obesity mostly or even completely mediated the relationship between nutrient patterns and hyperuricemia, especially traditional obesity indicators play a key intermediary effect. Proportion of indirect effect for BMI and WC were as high as 53.34 and 59.69, respectively.Conclusions: Our findings suggest that the direct effect of diet on hyperuricemia is weak, and obesity plays a critical mediated role in the pathway between diet and hyperuricemia, which confirms that weight-loss diet may be useful in preventing hyperuricemia.
The Role Of Systemic Immune Inflammatory Index To Show The Active Lesion In The Patients With Multiple Sclerosis
Authors: Gokce Seyda Figul , Bolayir Asli , Cigdem Burhanettin , Yildiz Bulent
Published: July 2022

Background: Multiple Sclerosis (MS) has two pathophysiological processes, one is inflammatory and the other is degenerative. We searched the relation between inflammatory biomarkers within the serums of patients who have active lesions in neuroimaging, and the existence, number, and localization of active lesions, as an indicator of the inflammatory process. Also, regardless of the imaging, we aim to detect the inflammatory period in which clinical, radiological follow-up, and disease-modifying treatments are effective with serum parameters.Methods: One hundred eighty six MS patients, presented to our hospital between January 2016 to November 2021 and 94 age-and- sex-matched healthy volunteers were recruited for our study. While 99 patients had active lesions in magnetic resonance imaging, 87 patients didn’t have any active lesion. Neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), monocyte/lymphocyte (MLR) ratios were determined. SII (systemic immune inflammatory index) value was calculated according to the platelet X neutrophil/lymphocyte ratio formula.Results: NLR, MLR and especially PLR, SII ratios were found to be statistically highest in the patient group with active lesions. According to the presence of active lesions, cut-off values for MLR, PLR, NLR and SII were respectively 0.18, 1.53 and 117.15, 434.45.Conclusions: We found that SII and PLR values were correlated with radiological activity. As easily accessible, inexpensive markers, SII and PLR can detect the inflammatory period in which patients have a higher response to treatment, with sufficient sensitivity and specificity. It can also be a helpful evaluation candidate for the presence of radiological activity.
Mo content-depended competition between the Cr2O3 enrichment and selective dissolution of CoCrFeNiMox high entropy alloys
Authors: Wang Xian-Zong , Hu Qian , Ye Cheng-Ping , Zhang Shang-Chen , Du Cheng-Feng , Wang Haifeng
Published: July 2022

The corrosion and passivation behavior of CoCrFeNiMox (x = 0, 0.2, 0.4, 0.6, 0.8, and 1.0) high entropy alloys (HEAs) are investigated. With the addition of Mo, increasing Mo and Cr riched σ/μ phases precipitate from the primary FCC phase. The corrosion resistance of the CoCrFeNiMox HEAs strongly depends on the phase structure and the passive film formed on the surface. Generally, Mo promotes the selective dissolution of the FCC phase and the enrichment of Cr2O3 in the passive film, the former deteriorates the corrosion resistance while the latter enhances it. Interestingly, the hypoeutectic Mo0.6 exhibits a higher corrosion resistance than that of Mo0.4, eutectic Mo0.8, and hypereutectic Mo1. Analysis of surface passive film the composition of alloy phases implies that the Cr2O3 enrichment dominates in Mo0.6 while selective dissolution governs in Mox (x = 0.4, 0.8, and 1.0). Mo content-depended competition between the Cr2O3 enrichment and selective dissolution is discussed.
The Type of Health Service Utilization in Mumbai Slums including Mobile Health Services: A Community Based Survey
Authors: Patwardhan Maitreyee , Li Shang-Ju , Khushalani Dipika , Dere Harshwardhan , Desai Shripad
Published: July 2022

Objective
Sociodemographic factors influence slum dwellers health seeking behaviors such as choosing a health facility. To better understand the health-seeking behaviors among the slum dwelling residents in Mumbai, India, a cross-sectional community needs assessment was conducted under the support of the Rural India Supporting Trust (RIST).
Results
432 respondents reported using some type of health facility within the past year, including 172 reporting use of private hospitals, 208 reporting use of public hospitals, 23 reporting use of Community Health clinics, and 29 reporting use of some other form of healthcare service. Logistic regression showed that female participants were significantly negatively associated with choosing a general practitioner (log-odds: -0.22, SE: 0.08). Higher education (log-odds: 0.16, SE: 0.08) and higher income (log-odds: 0.28, SE: 0.10) are significantly positively associated with choosing a private hospital. High income was found to be significantly negatively associated with choosing a government hospital (log-odds: -0.23, SE: 0.10). Education was also found to be significantly negatively associated with choosing a community health center (log-odds: -0.40, SE: 0.20). This study showed that health-seeking behaviors for health facilities are consistent with previously published results.
Dissipation Kinetics, Effect of Household Processing, and Dietary Risk Assessment of Chlorantraniliprole Residue in Bitter Gourd and Soil
Authors: MAWTHAM M.M. , Kaithamalai Bhuvaneswari , Angappan Suganthi , Kulanthaisami S
Published: July 2022

A single quadrupole liquid chromatography-mass spectrometry (LC-MS) method was validated to determine chlorantraniliprole residues in bitter gourd fruit, juice, and soil, according to the SANTE guidelines. A linear curve was obtained (R2 > 0.99) with LOD and LOQ at 0.003 mg kg-1 and 0.01 mg kg-1. The accuracy (87–102%) and precision (RSD <5%) of the method was found to be satisfactory. The dissipation pattern of chlorantraniliprole 18.5% SC was studied by spraying twice at ten days intervals, at the recommended dose (X) (25 g a.i. ha-1), and double the recommended dose (2X) (50 g a.i. ha-1). The initial deposit on bitter gourd was 0.72 and 1.41 mg kg-1 and residues persisted up to 15 and 20 days with a half-life of 2.44 and 2.79 days at X and 2X doses, respectively. Simple decontamination techniques were found to reduce residues to the extent of 30 to 80 per cent. The reduction of chlorantraniliprole residues in bitter gourd juice was 40-50 per cent by different washing techniques. The estimated level of RQ indicated (<1) chlorantraniliprole residues pose no dietary risk to consumers at the level detected. Chlorantraniliprole was not found in market and farmgate samples of bitter gourd.
Recombinant ovine prion protein can be mutated at position 136 to improve its efficacy as an inhibitor of prion propagation
Authors: Kopycka Katarzyna , Maddison Ben C. , Gough Kevin C.
Published: July 2022

Prion diseases are progressive neurodegenerative disorders with no effective therapeutics. A central event leading to the pathology in the diseases is the conversion of PrPC into PrPSc and its accumulation in the central nervous system. Previous studies demonstrated that PrPC, recombinant PrP (rPrP) and PrP peptides can inhibit the formation of PrPSc. Here, the effectiveness of ovine rPrP mutants at codon 136 and peptides derived from this region were assessed for their ability to inhibit PrPSc replication, using protein misfolding cyclic amplification (PMCA). Based on a rPrP VRQ (rVRQ) genotype background (positions 136, 154 and 171) and mutations at position 136, the most effective inhibitors were V136R, V136K and V136P mutants, with IC50 values of 2–11 nM; activities up to 57 times more potent than rVRQ. rRRQ was also shown to inhibit a range of ruminant prion amplification reactions including with distinct prion strain seeds and substrate PRNP genotypes. The rRRQ was also shown to effectively protect Rov9 cells from scrapie infection when applied at 250 nM. The study demonstrates for the first time that the rPrP sequence can be mutated at sites known to be involved in prion disease susceptibility, to produce inhibitors with improved efficacy.
The Unmet Mental Health Needs of adolescents living With HIV in Eastern Tanzania: Experiences of healthcare providers, adolescents, and caregivers
Authors: Njau Tasiana , Sunguya Bruno , Mwakawanga Dorkasi L. , Minja Agape , Kaaya Sylvia , Fekadu Abebaw
Published: July 2022

Background
Adolescents living with the Human Immunodeficiency Virus (ALWHIV) are at greater risk for depression than their HIV-negative counterparts and may not receive adequate mental health care. In Tanzania, there are no available data on the need for mental health services, particularly interventions for Depression in ALWHIV. Therefore, this study aimed to explore subjective experiences and unmet mental health needs of ALWHIV in Dar es salaam, Tanzania.
Methods
A phenomenological qualitative study design was used. Forty-five in-depth interviews and consultative meetings were conducted with ALWHIV, caregivers, and healthcare providers to explore their experiences and unmet mental health needs for ALWHIV. Data from the consultative meetings with providers were triangulated to validate the obtained information with those from interviews. Data were organized and managed with the aid of NVIvo-11. The thematic analysis framework guided the analysis of data.
Results
High unmet mental health needs were identified because of gaps in access to mental health care and mental health knowledge among health care providers and caregivers of ALWHIV. Depressive symptoms expressed as physical, behavioral, or somatic complaints adversely affect ART adherence, academic performance, substance use, and overall quality of life in ALWHIV. HIV-Care and Treatment Centers (HIV-CTCs) did not conduct formal mental health screenings. Instead, caregivers and Health care providers (HCPs) addressed ALWHIV-related psychological symptoms with threats of death and corporal punishments. No evidence-based depression interventions existed in HIV-CTCs for observed symptoms.
Conclusions
This study reveals a high level of unmet mental health needs and a clear impact on the lives of ALHIV, which may have significant implications for treatment adherence. For improved health outcomes and quality of life for ALWHIV, there is an urgent need to develop effective and scalable interventions to address these mental health needs.
Effectiveness of the air-gap method in pediatric CT examinations
Authors: Masuda Takanori , Funama Yoshinori , Nakaura Takeshi , Sato Tomoyasu , Masuda Shouko , Kiguchi Masao , Oku Takayuki , Gotanda Rumi , Arao Keiko , Imaizumi Hiromasa , Arao Shinichi , Ono Atsushi , Hiratsuka Junichi , Awai Kazuo
Published: July 2022

Background: This study aims to investigate the suitability of the air gap method for radiation dose reduction in pediatric patients during computed tomography (CT) examinations.Methods: We use pediatric anthropomorphic phantoms with a 64 detector-row CT scanner while scanning the chest. A real-time skin dosimeter is placed on the scanner gantry and is positioned at the center of the phantom, on the dorsal surface of the body, and on the left and right mammary glands. In the conventional method, the distance between the CT table and the subject was 0 mm. In the air gap method, the distance between the CT table and subject was 150 mm. We perform a helical scan between the conventional and air-gap methods from the lung apex to the subdiaphragm. The values of the real-time skin dosimeter and image noise are measured and compared for each method.Results: Compared with the conventional method, it was possible to reduce the exposure dose and image noise by approximately 10% and 15%, respectively, using the air gap method (p < 0.05). Conclusion: The airs gap method was useful for reducing the radiation dose by approximately 10% during pediatric CT examinations compared with the conventional method.
Mediating effects of suicidal ideation in the relationship between psychological distress and non-suicidal self-injury among adolescents with major depressive disorder: The roles of sex and urban-rural status
Authors: Li Ruifen , Wang Yanni , Huo Lijuan , Zhu Feng , Zheng Tiansheng , He Kongliang , Lu Shiqi , Hao Jiayue , Li Peng , Su Li , Zhou Yongjie
Published: July 2022

Background
Non-suicidal self-injury(NSSI) is a major public concern, and psychological distress(PD) has been found to be an important risk factor of NSSI. However, little is known about the mediating mechanism underlying this relationship. This study aimed at testing the mediating effects of suicidal ideation(SI) in the relationship between PD and NSSI among adolescents with major depressive disorder. Additionally, it's unclear if this effect exists or differs between sexes or urban-rural status.
Methods
A total of 428 Chinese adolescents with major depressive disorder(MDD) from 9 provinces across China completed self-reported questionnaires regarding PD, SI and NSSI.
Results
The SI mediated the relationship between PD and NSSI, and the estimated ratio of the total effect of PD that could be explained by mediation through SI was 33.59%. The ratio was higher in female adolescents with MDD (39.23%) than in males(18.05%), and it was higher in urban adolescents with MDD(43.35%) than in rural adolescents with MDD(15.55%).
Conclusions
Among adolescents with MDD, PD may influence NSSI behavior through SI. Interventions aimed at reducing NSSI associated with PD may be enhanced by efforts to mitigate SI, especially in females and urban adolescents.
Investigating the response of Al12N12 and B12N12 fullerene-like nanocages toward X-aminopyridine (X = 2 and 3) molecules: DFT study
Authors: Fouegue Aymard Didier Tamafo , Tendongmo Hilaire , Ngankam Eric Sakué , Ntieche Rahman Abdoul
Published: July 2022

The adsorption of 2-aminopyridine (2-AP) and 3-aminopyridine (3-AP) on the external surface of Al12N12 and B12N12 fullerene-like nanocages (FLNs) is probed herein via DFT/M06-2X/6-311G(d,p) level of theory. Results obtained from the topological analysis demonstrated that the APs strongly interact with the boron nitride FLN through B-N covalent interactions with energy values of -345.22 and -328.55 kJ/mol respectively after the adsorption of 2-AP and 3-AP. Moreover, all FLN@X-AP states investigated are spontaneously formed. A significant change in the HOMO-LUMO band gap of B12N12, with values of 22.01 and 32.71 % have been obtained after the adsorption of 2-AP and 3-AP respectively. Accordingly, the conductivity of B12N12 is greatly enhanced by the adsorption of the APs. The above mentioned observations, combined with those found from the analysis of dipole moments and molecular electrostatic potential maps predict B12N12 to be more sensitive to the aminopyridines investigated than the Al12N12 FLN from the theoretical point of view.
Research on Fault Diagnosis of ZPW-2000R Track Circuit Based on OC-SVM and DNN
Authors: xie benkai , cai shuiyong , huang chunlei , yu jianli , chen guangzhi
Published: July 2022

Aiming at the problem that there are many types of faults in the current track circuit and it is difficult to obtain high-quality fault label data, this paper proposes a fault diagnosis method for ZPW-2000R track circuit based on OC-SVM and DNN. In this method, OC-SVM is first used to classify and identify 48 monitoring data collected by ZPW-2000R track circuit to collect signal data of different fault types; then the DNN method is used to train the collected fault data to automatically classify the known fault data. A large number of experiments were carried out on this method using the data of ZPW-2000R track circuit, the diagnostic experimental results show that the proposed fault diagnosis method can effectively automatically collect the novel fault data and accurately detect the fault type, and the accuracy of fault diagnosis can reach more than 98%.
Effect of biodegradable poly-3-hydroxybutyrate amendment on the soil biochemical properties and fertility under varying sand loads
Authors: Brtnicky Martin , Pecina Vaclav , Holatko Jiri , Hammerschmiedt Tereza , Mustafa Adnan , Kintl Antonin , Fojt Jakub Fojt , Baltazar Tividar , Kucerik Jiri
Published: July 2022

Background: Poly-3-hydroxybutyrate (P3HB) is a bacterial intracellular carbon and energy storage polymer, used as a thermoplastic polyester in a wide array of industrial and agricultural purposes. However, it has been relatively unexplored how are the soil microbiome and fertility altered by exogenously applied P3HB. This study aimed to assess the effects of P3HB addition to nutrient restricted soil: its biological properties and lettuce (Lactuca sativa L. var. capitata L.) biomass production. The experiment was designed to the evaluate impacts of spatial arrangement of the relatively organic-rich (soil organic matter, P3HB particles) versus poor fractions of the matrix with confounding factors such as variable microbial biomass, inherent nutrient/energy status, different water relations (due to variable hydrophysical properties of soil augmented by sand at different ratios). Results: The results revealed that P3HB induced inconsistent to contradictory changes in the microbial abundance as well as in most enzymatic activities depending on the sand content. On the other hand, dehydrogenase and urease activities as well as basal and substrate induced soil respirations were mostly enhanced by P3HB addition. Nevertheless, P3HB significantly inhibited lettuce biomass production. Conclusions: We concluded that the P3HB introduction to soil boosts the microbial activity owing to the preferential utilization of P3HB as C source, which depletes soil N and strongly inhibits the plant growth. There was an enhanced microbial activity in P3HB amended soils with high sand content (60–80%), which suggested that in nutrient impoverished soil P3HB can temporarily replace SOM as a C source for microbial communities due to the shift of their structure to preferentially P3HB-degrading microbiome.