bluuebunny/crossref_metadata_2025 huggingface dataset:
O DIREITO AO ESQUECIMENTO: A EXCLUSÃO DE NOTÍCIAS QUE FEREM A INTEGRIDADE E INTIMIDADE DA PESSOA E A ATUAL DISCUSSÃO DO SUPREMO TRIBUNAL FEDERAL
Authors: Ransolin Mariela Letícia Córdova , Baruffi Pedro Paulo
Published: January 2023

O direito ao esquecimento surge através de um longo processo histórico, tomando espaço nas jurisprudências e normatizações. Entretanto, no Brasil, o direito ao esquecimento vem sendo questionado, voltando a ser alvo de discussões dentro dos Tribunais, que acreditam na sobressalência da liberdade de expressão, mesmo que interfira gravemente na vida dos envolvidos do processo. Com a necessidade de demonstrar a importância da intimidade da pessoa humana, buscar-se-á explicar a gravidade da exposição midiática e a perda do direito ao esquecimento, direito este de suma importância para integridade do ser humano. Dessa maneira, o assunto tem grande relevância nesta temática pouco discutida, e que merece enfoque na atualidade. A metodologia utilizada é bibliográfica documental através do método indutivo com estudo de caso.
PALAVRAS CHAVE: Direito; esquecimento; integridade.
ABSTRACTThe right to be forgotten arises through a long historical process, taking space injurisprudence and regulations. However, in Brazil, the right to be forgotten has beenquestioned, returning to the subject of discussions within the Courts, which believe in thesupremacy of freedom of expression, even if it seriously interferes in the lives of thoseinvolved in the process. With the need to demonstrate the importance of human intimacy,it will seek to explain the seriousness of media exposure and the loss of the right to beforgotten, a right that is of paramount importance for the integrity of the human being. Inthis way, the subject has great relevance in this little-discussed theme, and which deservesfocus today. The methodology used is documentary bibliography through the inductivemethod with case study.
Keywords: Right; forgetfulness; integrity.
DIREITO FUNDAMENTAL À PROTEÇÃO DE DADOS E À PRIVACIDADE NA ERA DOS ALGORITMOS E POSSÍVEIS MECANISMOS DE PROTEÇÃ
Authors: Santiago Lucas Laura Maria , Felix Talita
Published: January 2023

Este artigo tem como objetivo realizar um breve estudo acerca da proteção de dados como direito fundamental em uma sociedade dominada, vigiada e direcionada pelos algoritmos e pela inteligência artificial. Será abordado como os algoritmos vigiam e direcionam as ações de seus usuários e ainda como os dados coletados pelos algoritmos muitas vezes compartilhados pelos próprios usuários, que confiam excessiva no ambiente virtual, são transformados em produto precioso na economia atual. Será estudado como o compartilhamento de dados viola direitos e deixa os usuários em total fragilidade no sistema dominado pelos algoritmos. Será abordado que o compartilhamento de dados, não se constitui em mera violação de direitos à privacidade, pois em uma sociedade da informação, os dados são fonte de poder e de dominação. Serão relacionadas normas criadas com o fim de proporcionar maior segurança aos usuários que utilizam das plataformas digitais e, também sobre a necessidade de se entender que à proteção de dados merece proteção especial.   Será falado também acerca da Emenda Constitucional n. 115 de 2022 que elevou à proteção de dados ao status de direito fundamental. Por último, certos de que as normas, por si só, não trazem a segurança almejada, embora seja um grande avanço, serão disponibilizados Mecanismos de proteção dos dados pessoais na era dominada pelos algoritmos.
PALAVRAS CHAVE: Algoritmos; Compartilhamento de dados; Sociedade do Controle; Proteção de Dados; Direito Fundamental.
ABSTRACT
This article aims to conduct a brief study on data protection as a fundamental right in a society dominated, monitored and directed by algorithms and artificial intelligence. It will be addressed how algorithms monitor and direct the actions of their users and also how the data collected by algorithms often shared by the users themselves, who rely excessively on the virtual environment, are transformed into a precious product in today's economy. It will be studied how data sharing violates rights and leaves users in total fragility in the system dominated by algorithms. It will be addressed that data sharing does not constitute a mere violation of privacy rights, because in an information society, data is a source of power and domination. Standards created to provide greater security to users using digital platforms and also on the need to understand that data protection deserves special protection.  It will also be talked about Constitutional Amendment No. 115 of 2022 that elevated data protection to the status of fundamental law. Finally, certain that the standards alone do not bring the desired security, although it is a major advance, mechanisms for the protection of personal data will be made available in the era dominated by algorithms.
Keywords: Algorithms. Data sharing; Control Society; Data Protection; Fundamental Law.
O IMPACTO DAS DECISÕES DO SUPREMO TRIBUNAL FEDERAL NAS POLÍTICAS PÚBLICAS EM TEMPOS DE PANDEMIA POR COVID-19
Authors: Gonçalves Sandra Krieger
Published: January 2023

A partir da estipulação constitucional brasileira que cria um sistema de saúde com dois subsistemas, efetua-se uma breve análise acerca de uma jurisprudência estruturada em um binômio política pública e judicialização do direito à saúde.  Tem-se como foco demonstrar a repercussão das decisões proferidas em saúde após a decretação do estado de calamidade pública/emergência em decorrência da pandemia da Covid-19. Busca-se explanar o papel assumido pelo Poder Judiciário na concretização dos direitos fundamentais à saúde, desaguando em uma apreciação sobre os reflexos de algumas e determinadas decisões da Suprema Corte no Direito sanitário brasileiro, selecionadas por amostragem não aleatória. Trata-se de  pesquisa qualitativa, do tipo descritiva e exploratória, com abordagem teórica e fundamentada em pesquisa bibliográfica.
PALAVRAS CHAVE: Sistemas de Saúde; Sistema Único de Saúde – SUS; Políticas Publicas de Saúde; Judicialização; Supremo Tribunal Federal.
ABSTRACT
Based on the Brazilian constitutional stipulation that creates a health system with two subsystems, a brief analysis is made of a jurisprudence structured in a binomial public policy and judicialization of the right to health. The focus is on demonstrating the impact of decisions made in health after the decree of a state of public calamity/emergency as a result of the Covid-19 pandemic. It seeks to explain the role assumed by the Judiciary in the realization of fundamental rights to health, flowing into an appreciation of the effects of some and certain decisions of the Supreme Court on Brazilian health law, selected by non-random sampling. This is a qualitative, descriptive and exploratory research, with a theoretical approach and based on bibliographical research.
Keywords: Health Systems; Unified Health System; Public Health Policies; Judicialization; Federal Court of Justice
INTEGRATIVE AND BIOCHEMICAL PARAMETERS IN RATS IN THE SIMULATION OF DOXORUBICIN CHRONIC HEART FAILURE AND DURING THE USE OF Β-ADRENERGIC BLOCKERS
Authors: BELENİCHEV Igor , BAK Pavlo , POPAZOVA Olena , RYZHENKO Victor , BUKHTİYAROVA Nina , PUZYRENKO Andrii
Published: January 2023

β-adrenergic blockers have been actively used in the treatment of heart failure, which relieve excessive sympathetic stimulation of the myocardium, reduce calcium overload of cardiomyocytes, reduce the heart's oxygen demand, inhibit lipid peroxidation and stabilize cell membranes, have an antiarrhythmic effect. The aim: to compare efficiency of various drugs with new potential "Hypertril" in the conditions of modeling doxorubicin chronic heart failure (CHF) to improve parameters. Objective: CHF was modeled on 85 white outbred rats weighing 190–220g by administering doxorubicin at a cumulative dose of 15 mg/kg. Material and metods: Nebivalol, Carvedilol, Bisoprolol, Metoprolol and Hypertril were administered intragastrically once a day in the form of a suspension of 1% starch mucus for 30 days after a 14-day administration of doxorubicin. To determine damage, we used the solid-phase immunosorbent sandwich ELISA method, enzyme immunoassay and the immunoturbodimetric method. Result and discussion: Administration of Hypertril to rats with CHF led to a decrease in the blood of the main molecular markers of CHF to the values of intact animals, which indicated its significant cardioprotective effect in comparison with other drugs. Hypertril reduces manifestations of mitochondrial dysfunction, protects the myocardium and positively affects the morphological and functional parameters of cardiomyocytes, inhibits apoptosis
Channelling of basal resources and use of allochthonous marine carbon by soil arthropods of the Wadden Sea salt marsh
Authors: Rinke M , Lõhmus K , Pieck D , Maraun M , Scheu S
Published: January 2023

Salt marshes are located between the marine and terrestrial systems. Because they form as sediment accumulates, they comprise a gradient of shore height with differing inundation frequencies and associated abiotic soil conditions. Along this gradient, both autochthonous vascular plant resources and allochthonous marine algal or detrital resources are available, with the availability of both varying with season and salt marsh zone. However, little is known about the importance of either resource for the soil-animal food web. We investigated both spatial and temporal resource use of soil macro- and mesofauna in a salt marsh using neutral lipid fatty acid (NLFA) analysis. Generally, irrespective of season and zone, the soil-animal food web relied on carbon originating from autochthonous vascular plants and associated bacteria and fungi, with the role of bacteria generally exceeding that of fungi. However, the channelling of fungal resources consistently peaked in October, whereas seasonal changes in the channelling of plant and bacterial resources varied among salt marsh zones. Further, variations in the channelling of resources with season and zone varied among salt marsh animal species. Allochthonous resources of marine origin provided only a minor contribution to soil food web nutrition across salt marsh zones and seasons. The contribution of algae to soil food web nutrition depended on inundation frequency and season, i.e. algal productivity. Overall, the results demonstrate that the salt marsh soil fauna predominantly relies on autochthonous vascular plant resources, with the contribution of allochthonous marine resources being minor and restricted to a few taxa.
Polymyalgia Rheumatica and Seronegative Elderly-Onset Rheumatoid Arthritis: Two Different Diseases with Many Similarities
Authors: Manzo Ciro , Emamifar Amir
Published: January 2023

Polymyalgia rheumatica (PMR) and seronegative elderly-onset rheumatoid arthritis (SEORA) are two of the most frequent inflammatory rheumatologic diseases in elderly patients. At first presentation, there are many similarities between PMR and SEORA, that may lead to a real diagnostic conundrum. The most relevant similarities and differences between PMR and SEORA are discussed in this review. In addition to the acute involvement of the shoulder joints, important features characterising both diseases are morning stiffness longer than 45 minutes, raised erythrocyte sedimentation rate, and a good response to low doses of prednisone. Some findings (such as erosive arthritis or symmetrical involvement of metacarpophalangeal and/or proximal interphalangeal joints) can help to make the diagnosis of SEORA, whereas shoulder and hip ultrasonography and 18-FDG PET/CT seem to be less specific. However, in several patients only long-term follow-ups confirm the initial diagnosis. A definite diagnosis of PMR or SEORA has significant therapeutic implications, since patients with PMR should be treated with long-term glucocorticoids, and sometimes throughout life, which predisposes the patients to serious side effects. On the contrary, in patients with SEORA, short-term treatment with glucocorticoids should be considered when initiating or changing disease modifying antirheumatic drugs, followed by rapid tapering.
Type 2 Inflammation and the Evolving Profile of Uncontrolled Persistent Asthma
Authors: Saul Helen
Published: January 2023

The objective of this symposium was to provide an overview of Type 2 inflammation in asthma. The speakers covered the pathophysiology of Type 2 asthma, its heterogeneity, the associated economic burden, and methods for recognising Type 2 inflammation in severe asthma patients in clinical practice.

Asthma is a heterogenous disease and multiple phenotypes are common among patients. Type 2 asthma is so named because it is associated with Type 2 inflammation and typically includes allergic asthma and moderate-to-severe eosinophilic asthma, Prof Canonica explained. By contrast, non-Type 2 asthma commonly has an older age of onset and is often associated with obesity and neutrophilic inflammation.

Prof Diamant highlighted the scale and severity of uncontrolled persistent asthma. Globally, an estimated 420,000 people die of asthma every year, and many more have uncontrolled disease, putting them at risk of persistent airway inflammation and eventual lung decline. Patients may not recognise that their disease is uncontrolled, despite exacerbations and the impact of their asthma on daily activities. Prof Diamant described the impairments to health-related quality of life and the associated costs of uncontrolled asthma.

Prof Dahlén outlined how new predictive biomarkers will be needed to identify the type of asthma an individual patient has. No single biomarker will provide sufficient information, and as such, in the future, profiles of many markers will need to be integrated to produce subgroup-specific profiles for use in personalised medicine. He described ongoing research into protein arrays and lipid mediators in urine, and how cluster analysis and pattern recognition, with the aid of artificial intelligence, will form the basis of future diagnostic tools. Prof Canonica explained that an understanding of the mechanisms of asthma is important in achieving better symptom control. IL-4 and IL-13 are key players in the pathobiology of uncontrolled persistent asthma (IL-4 in inflammation and IL-13 in airway remodelling), but their roles overlap. The heterogenous nature of Type 2 asthma can make it difficult to diagnose; therefore, focussing on a single biomarker is likely to leave some patients sub-optimally controlled.
AKP’li Yıllarda Türkiye Ekonomisi: Panoramik Bir Değerlendirme
Authors: Atbaşı Ferda , Öziş Mustafa , Kurtulmuş Miris Meryem
Published: January 2023

AKP hükümetinin ekonomi politikalarının değerlendirilmesinde genel bir uzlaşı vardır. Kimileri hükümeti 2002- 2013'yılları arasında temel ekonomik parametreler açısından başarılı bulurken, sonraki dönemde başarısızlığın sebeplerinin neler olduğu konusunda bahsedilen uzlaşma yerini ‘resmi’ ve ‘muhalif’ olmak üzere iki farklı açıklamaya bırakmıştır. ‘Resmi’ görüş, olası başarısızlığı ülke dışındaki ‘güçler’ tarafından mevcut hükümete karşı komplo yapıldığı senaryolarına dayandırmaktadır. ‘Muhalif’ görüş ise ikinci on yıldaki başarısızlığı ilk dönemde uygulanan politikaların değişmesine bağlamaktadır. Bu makalenin amacı, Türkiye ekonomisinin son yirmi yıldaki ekonomik performansına ilişkin mevcut görüşleri eleştirel bir şekilde tartışmak ve yeni bir görüş önermektir. Bunun için üç yönlü bir analiz yapılmıştır. İlk olarak, Türkiye ekonomisinin finansal ve endüstriyel performansı ve değişen ekonomi politikalarının sürdürülebilirliği betimsel bir veri analizi ile değerlendirilmektedir. Ardından, hükümetin kendi ürettiği ekonomik raporlardaki itiraf ve ifadelerin izlerini sürerek ‘uzlaşı’ eleştirel bir şekilde tartışılmaktadır. Son olarak, uygulanan ekonomi politikalarının bölüşümsel etkileri incelenmektedir.
Uluslararası İlişkileri Film Üzerinden Öğretmek: Caydırıcılığın Dr. Strangelove ve Fail-Safe Filmlerinde İşlenmesi
Authors: BALABAN Gökçe
Published: January 2023

Uluslararası ilişkiler kavramları yazılı metinlere bağlı kalmadan nasıl öğretilebilir? Son yıllarda artan sayıda araştırma bu soruyu cevaplamaya çalışmaktadır. Mevcut makale de filmler üzerinden bu gelişen literatüre katkıda bulunmayı hedeflemekte, Soğuk Savaş siyaseti açısından temel bir kavram olan caydırıcılığın Dr.Strangelove ve Fail-Safe filmleri üzerinden nasıl öğretilebileceğini ortaya koymayı amaçlamaktadır. Buna göre öğrenciler ders saati dışında filmleri caydırıcılığın tanımı, caydırıcılıkta rasyonalite ve caydırıcılıkta inandırıcılık temaları üzerinden izleyecek, ders saatinde ise bu temaların filmlerdeki işlenişi seminer öğretim modeliyle tartışılacaktır. Makale, aynı zamanda caydırıcılığın belirtilen temalarının filmlerde nasıl işlendiğini de örnek olarak gösterecek, bu şekilde Dr. Strangelove ve Fail-Safe filmlerinin caydırıcılık kavramının öğretilmesi açısından zengin birer kaynak olduklarını ortaya koyacaktır.
Poetic Objects: Bachelardian Reverie, Reverberation and Repose in Claire Denis'35 Shots of Rum
Authors: Walton Saige
Published: January 2023

This article draws on the interrelated concepts of reverie and repose in Gaston Bachelard's philosophy to approach Claire Denis' poetic foregrounding of objects in 35 Shots of Rum ( 35 Rhums, 2008). Connecting Bachelard's work on time to his later studies of the imagination, I demonstrate how the poetic time of reverie and repose are essential to Bachelard's thinking. Focusing on three especially charged objects (trains, rice cookers and lanterns), I argue for reverie and repose as being embedded into the rhythmic structure, affective organisation and form of Denis' film. Contextualising Bachelard's later thinking in relation to Eugène Minkowski, I maintain that Denis' objects reverberate (both formally and sensuously). In 35 Shots of Rum, Denis' poetic objects and her evocation of different in-between states parallels Bachelard's own materialist thinking on the imagination, reverie and repose.
THE EFFECTS OF DEHYDRATION ON COLOR CHANGE IN NATURAL TEETH CAUSED BY DENTAL PROCEDURES
Authors: EROGLU Erdal , TEMEL Uğur Burak , BAŞAĞAOĞLU DEMİREKİN Zeynep , GÜRDAL Osman
Published: January 2023

This study examines the effects of several clinical procedures that lead to dehydration on color change in natural teeth. CIE L*, a*, and b* color coordinates of maxillary incisors were measured using a spectrophotometer before and after the procedure at minute intervals of 10, 20, 30, and 1440 (24 hours). Test groups were as follows: 6 and 15 minutes of the open mouth under LED and halogen dental reflectors; control groups were evaluated in a dark environment for 6 and 15 minutes; maxillary impressions were taken with condensation and additional type impression materials. Wilcoxon signed-rank tests and Mann–Whitney U tests were used for two-group comparisons. The analyses were computed by the Friedman and Kruskal–Wallis H tests for the paired and independent groups. These tests were followed by Bonferroni posthoc corrections. Obtained color values indicate significant L* changes for all groups due to dehydration for 20 minutes after the procedure. Color changes (ΔE) were significant for 30 minutes for the perceptibility (1.2>ΔE) and 20 minutes for the acceptability threshold (2.7>ΔE). Results show that experimental protocols designed to mimic dental procedures that require mouth opening may cause temporary discoloration of natural teeth, which may cause failure during shade matching.
KOLOREKTAL KANSER CERRAHİSİ GEÇİRECEK HASTALARIN AMELİYAT ÖNCESİ KONSTİPASYON RİSKİ
Authors: YÜCELER KAÇMAZ Hatice , YILMAZ İlker , SÜRME Yeliz , CEYHAN Özlem , AKYILDIZ Hızır Yakup
Published: January 2023

Kolorektal kanser, tüm dünyayı etkileyen önemli sağlık sorunlarından biridir. Kolorektal kanserin öncelikli tedavi yöntemi cerrahidir. Cerrahi işlemler sonrası sıklıkla yaşanan konstipasyon, postoperatif dönemde hastaların yaşam kalitesini, konforunu, solunum ve dolaşım sistemlerini ve iyileşmeyi etkileyen önemli bir problemdir. Bu çalışma kolorektal kanser cerrahisi geçirecek olan hastaların ameliyat öncesi konstipasyon risklerini belirlemek amacıyla yapılmıştır. Bu kesitsel araştırma, Mart 2017-Mart 2018 tarihleri arasında bir üniversite hastanesinde kolorektal kanser nedeniyle takip edilen 91 hastayla yürütülmüştür. Veriler kolorektal cerrahiden bir gün önce hastalara tanıtıcı bilgi formu ve konstipasyon risk değerlendirme ölçeği uygulanarak toplanmıştır. Çalışmada hastaların konstipasyon risk ölçeği puan ortalaması 11.52±3.40 olup, %42.4’ü düşük, %29.3’ü orta, %28.3’ü yüksek konstipasyon riski taşımaktadır. Kronik hastalık (p=0.027) ve düzenli ilaç kullanımı (p=0.031) ile konstipasyon riski arasında istatistiksel olarak anlamlı farklılık bulunmaktadır. Kolorektal kanser cerrahisi sonrası hastalar konstipasyon gelişimi açısından orta derecede risk altındadır. Kolorektal kanser cerrahisi öncesi hastaların konstipasyon gelişme riski açısından değerlendirilmesi ve postoperatif erken dönemde bu hastalara kontipasyona ilişkin müdahale yapılması önerilebilir.
Decomposition of Natural Numbers from Prime Objects
Authors: Sebata Junya
Published: January 2023

We decompose natural numbers from structure which prime numbers have, as its starting point. With the decomposition, we can find a general law by categorization, which is in a power set and also in structure which prime numbers have, and we know that it limits the framework of structure about product and sum of natural numbers. In other words, $\sum_{k=1}^{n} \phi (k) \times [\frac{n}{k}] = \frac{n(n+1)}{2}$ holds, and it is equivalent to a basic formula of sum of divisors $\sum_{k|n} \phi (k) = n$.
Låt NO-språket gro med PEN-modellen
Authors: Kristiansson Richard
Published: January 2023

I denna essä beskrivs en modell som har teoretisk förankring i Systemisk Funktionell Lingvistik (SFL). Modellen är ett didaktiskt verktyg för lärare och illustreras i essän med elevskrivna laborationsrapporter i NO. Rapporterna undersöks genom att identifiera NO-ord och ord som beskriver experimentmaterial å ena sidan, och processord å andra sidan. Processorden är verb som beskriver vad som görs eller händer i ett experiment eller undersökning. Resultaten indikerar att modellen erbjuder lärare, att på ett systematiskt sätt, uppmärksamma inte bara NO-ord utan även processord som beskriver aktiviteter och skeenden. Modellen kan därför användas för att studera elevers språkbruk, vilket kan hjälpa lärare att stödja eleverna när de utvecklar sitt språkliga register i naturvetenskap.
A droplet digital PCR assay for detection and quantification of Verticillium nonalfalfae and V. albo-atrum
Authors: Wang Di , Liu Enliang , Liu Haiyang , Jin Xi , Niu Chunyan , Gao Yunhua , Su Xiaofeng
Published: January 2023

Verticillium nonalfalfae and V. albo-atrum are notorious pathogenic fungi that cause a destructive vascular disease called Verticillium wilt worldwide. Thus, timely and quantitative monitoring of fungal progression is highly desirable for early diagnosis and risk assessment. In this study, we developed a droplet digital polymerase chain reaction (ddPCR) assay to detect and quantify V. nonalfalfae and V. albo-atrum. The performance of this assay was validated in comparison with that of a quantitative real-time polymerase chain reaction (qPCR) assay. The standard curve analysis of the ddPCR assay showed good linearity. The ddPCR assay indicated similar detection sensitivity to that of qPCR on pure genomic DNA, while it enhanced the positive rate for low-abundance fungi, especially in alfalfa stems. Receiver operating characteristic analysis revealed that ddPCR provided superior diagnostic performance on field tissues compared to qPCR, and the area under curve values were 0.94 and 0.90 for alfalfa roots and stems, respectively. Additionally, the quantitative results of the two methods were highly concordant (roots: R2 = 0.91; stems: R2 = 0.76); however, the concentrations determined by ddPCR were generally higher than those determined by qPCR. This discrepancy was potentially caused by differing amplification efficiencies for qPCR between cultured and field samples. Furthermore, the ddPCR assays appreciably improved quantitative precision, as reflected by lower coefficients of variation. Overall, the ddPCR method enables sensitive detection and accurate quantification of V. nonalfalfae and V. albo-atrum, providing a valuable tool for evaluating disease progression and enacting effective disease control.
Toward immersive communications in 6G
Authors: Shen Xuemin (Sherman) , Gao Jie , Li Mushu , Zhou Conghao , Hu Shisheng , He Mingcheng , Zhuang Weihua
Published: January 2023

The sixth generation (6G) networks are expected to enable immersive communications and bridge the physical and the virtual worlds. Integrating extended reality, holography, and haptics, immersive communications will revolutionize how people work, entertain, and communicate by enabling lifelike interactions. However, the unprecedented demand for data transmission rate and the stringent requirements on latency and reliability create challenges for 6G networks to support immersive communications. In this survey article, we present the prospect of immersive communications and investigate emerging solutions to the corresponding challenges for 6G. First, we introduce use cases of immersive communications, in the fields of entertainment, education, and healthcare. Second, we present the concepts of immersive communications, including extended reality, haptic communication, and holographic communication, their basic implementation procedures, and their requirements on networks in terms of transmission rate, latency, and reliability. Third, we summarize the potential solutions to addressing the challenges from the aspects of communication, computing, and networking. Finally, we discuss future research directions and conclude this study.
Inflammation index SIRI is associated with increased all-cause and cardiovascular mortality among patients with hypertension
Authors: Zhao Songfeng , Dong Siyuan , Qin Yongkai , Wang Yutong , Zhang Baorui , Liu Aihua
Published: January 2023

Background

Inflammation plays an essential role in the pathogenesis of hypertension. A novel inflammatory biomarker systemic inflammatory response index (SIRI) is related with all-cause and cardiovascular (CVD) mortality, while the role of SIRI in hypertension patients is unclear.

Methods

A total of 21,506 participants with hypertension were recruited in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018. SIRI was calculated as the neutrophil count * monocyte count/lymphocyte count. Hypertension was defined according to the examination of blood pressure, prescription, and self-reported physician diagnosis. Survival status was followed through 31 December 2019. The non-linear relationship was assessed using restricted cubic spline analysis. The association of all-cause mortality with SIRI was evaluated using the Kaplan–Meier curve and the weighted Cox regression analysis. The predictive abilities were assessed with Receiver operating curve.

Results

During 189,063 person-years of follow-up, 5,680 (26.41%) death events were documented, including 1,967 (9.15%) CVD related deaths. A J-shaped association was observed between SIRI and all-cause and CVD mortality. The Kaplan–Meier curve indicated the all-cause and CVD mortality risks were higher in high SIRI quartiles compared with lower SIRI quartiles. After adjusting for all covariates, the SIRI was positively associated with the all-mortality risk with HR = 1.19 (1.15, 1.22), and CVD mortality with HR = 1.19 (1.15, 1.24). The result was robust in subgroup analysis and sensitivity analysis.

Conclusion

Elevated SIRI level is associated with increased all-cause and CVD mortality among patients with hypertension. SIRI is considered as a potential inflammatory biomarker in the clinical practice. Further large-scale cohort studies are required to confirm our findings.
Qili Qiangxin capsules for chronic heart failure: A GRADE-assessed clinical evidence and preclinical mechanism
Authors: Xing Xiaoxiao , Guo Jianbo , Mo Juefei , Li Huashan , Zhang Hui , Shao Baoyi , Wang Yifan , Li Haidi , Wang Jianan , Leung Cheuk Lung , Jiang Yun , Yin Weixian , Chen Haiyong , He Qingyong
Published: January 2023

Introduction

Chronic heart failure (CHF) has become an increasing concern with the aging of the population. This study aims to evaluate the effectiveness and safety of Qili Qiangxin capsules (QLQX) for CHF.

Methods

A systematic review and meta-analysis on clinical studies was conducted. The mechanisms of preclinical studies were summarized.

Results

We searched six electronic databases by 20 July 2022, and finally, 7 preclinical experiments (PEs) and 24 randomized controlled trials were included. The risk of bias was accessed by the SYRCLE and RoB 2.0 tool, respectively. PEs indicated that QLQX suppresses myocardial apoptosis, inhibits renin-angiotensin-aldosterone system activation, improves water retention, and enhances cardiocyte remodeling. In clinical studies, compared with routine treatment, QLQX could improve the indicators: clinical efficacy rate (RR = 1.16, 95% CI [1.12, 1.22], GRADE: moderate), left ventricular end-diastolic dimension (SMD = −1.04, 95% CI [−1.39, −0.70], GRADE: low), left ventricular ejection fraction (SMD = 1.20, 95% CI [0.97, 1.43], GRADE: moderate), 6-minute walk distance (SMD = 1.55, 95% CI [0.89, 2.21], GRADE: low), brain natriuretic peptide (SMD = −0.78, 95% CI [−1.06, −0.51], GRADE: low), N-terminal pro-brain natriuretic peptide (SMD = −2.15, 95% CI [−3.60, −0.71], GRADE: low), and adverse events (RR = 0.46, 95% CI [0.25, 0.87], GRADE: low).

Discussion

In summary, QLQX exerts a potential mechanism of utility on myocardial apoptosis and cardiac function and has noteworthy clinical adjuvant efficacy and safety in patients with CHF.

Systematic review registration

https://www.crd.york.ac.uk/prospero/.
Case report: Echocardiographic diagnosis of double orifice mitral valve in an asymptomatic woman
Authors: Deng Zixian , Wang Xiaoyu , Liu Qiyun , Li Jianghua , Liu Huadong
Published: January 2023

Double orifice mitral valve (DOMV) is a rare congenital anomaly that is often associated with cardiac malformation. Valve dysfunction usually presents in childhood; therefore, most cases are diagnosed with DOMV in childhood. Its prevalence and prognostic relevance in adulthood are unknown. Here, we report a case of a 38-year-old woman who presented to the outpatient clinic with an abnormal electrocardiogram and was found to have an isolated double orifice mitral valve malformation on transthoracic echocardiography. Echocardiography is the diagnostic tool of choice for patients with double orifice mitral valves. We should familiarize ourselves with the echocardiographic features of DOMV in order to improve the detection.
Depthwise separable convolution Unet for 3D seismic data interpolation
Authors: Jin Zhenhui , Li Xinze , Yang Hui , Wu Bangyu , Zhu Xu
Published: January 2023

In seismic exploration, dense and evenly spatial sampled seismic traces are crucial for successful implementation of most seismic data processing and interpretation algorithms. Recently, numerous seismic data reconstruction approaches based on deep learning have been presented. High dimension-based methods have the benefit of making full use of seismic signal at different perspectives. However, with the transformation of data dimension from low to high, the parameter capacity and computation cost of training deep neural network increase significantly. In this paper, we introduce depthwise separable convolution instead of standard convolution to reduce the operation cost of Unet for 3D seismic data missing trace interpolation. The structural similarity (SSIM), L1 hybrid loss function, and switchable normalization further improve the reconstruction performance of the network. The comparative experiments on the synthetic and field seismic data show that depthwise separable convolution can effectively reduce the number of network parameters and computation intensity with the interpolation results comparable to the standard convolution results.
Revealing the shallow soil structure of the Yigong Lake in the Tibetan Plateau using a portable distributed acoustic sensing interrogator
Authors: Yang Jizhong , Zhou Jian , Zhang Heng , Xu Tuanwei , Deng Dimin , Geng Jianhua
Published: January 2023

The harsh and extreme environmental and near surface conditions of the Tibetan Plateau have limited the conventional electrical-based seismic instruments from obtaining high-quality seismic data through long-term and continuous observations, setting challenges for environmental seismology study and natural hazard monitoring in this area. Distributed acoustic sensing (DAS) is an emerging technique based on optical fiber communication and sensing. It provides a possible solution for subsurface imaging in extreme conditions at high spatiotemporal resolution by converting fiber-optic cables into dense seismic strainmeters. We deploy two survey lines with armored optical fiber cables in the Yigong Lake area, Southeastern Tibetan Plateau, to record ambient noise for a week. The DAS interrogator is specifically designed in a portable size with very low power consumption (25 W/h). Hence, we can use a 12V-DC battery for power supply to adjust the power limitation during the field recording. Ambient noise interferometry and multichannel analysis of surface waves are used to get 2D shear wave velocity profiles along the fiber paths. The results highlight the great potential of DAS for dynamic monitoring of the geological evolution of lakes and rivers in areas of extreme environments as in the Tibetan Plateau.
Methane emission characteristics and model of CBM wells
Authors: Dong Qingxiang , Wang Shengwei , Ma Jinkui , Lyu Shuaifeng , Lu Weiyong
Published: January 2023

CBM (CBM) development in coal mining area has good safety, economic and energy benefits, but methane emission is common in surface well sites. In view of this, taking the CBM wells in Qinshui County of Shanxi Province as an example, the methane emission location and emission volume of CBM wells are obtained, and the prediction model of methane emission volume is established through field investigation and multiple regression analysis. The results show that 81% of CBM wells have methane emission. Wellhead and drainage outlet are the two main positions of methane emission. The proportion of wells with emission volume between 0 and 10 m3/d is 59%. On the whole, the emission accounts for 1.53% of the gas well production. There is almost no methane emission in the single liquid phase flow stage. The methane emission in the gas-liquid two-phase flow stage is positively correlated with the bottom hole flow pressure, times of stroke and gas production, and negatively correlated with the pump embedment and water production. The bottom hole flow pressure and the pump embedment have the greatest impact on the methane emission. In the single-phase gas flow stage, methane emission is positively correlated with gas production and casing pressure, and negatively correlated with stroke frequency and water production.
System reliability analysis of landslides involving sliding surfaces using intelligent multiple response surfaces
Authors: Cai Zhenglong , Shou Silong , Zhou Jiawen , Tian Bin , Xiong Bobo , Meng Yongdong
Published: January 2023

The shear strength reduction method provides an effective tool of numerical analysis for landslides reliability analysis. However, it ignores the failure probability of the secondary failure surfaces and requires huge computational cost. To avoid these common criticisms, an intelligent multiple response surfaces method for system reliability using multiple response-surface method (MRSM) and least-squares support vector machine (LSSVM) is presented to evaluate the stability of complex multistage historic landslides with multiple sliding surfaces. Deterministic analysis of each sliding surface is first performed using the finite element method of sliding surface stress analysis, which is applied to obtain the safety factors of different sliding surfaces from the stress fields generated by finite element simulations. The LSSVM model with excellent nonlinear fitting ability is then employed to construct the multiple response-surface method (MRSM) of the sliding surfaces and a genetic algorithm (GA) is adopted to optimize the LSSVM. This proposed methodology is finally applied to investigate the probability of system failure of the Zhenggang landslide in southwestern China. The results indicate that the proposed approach can reduce the computational cost of finite element analysis in direct Monte Carlo simulation (MCS) by proper training using a limited of samples, and the calculation accuracy meets the engineering requirements of complex multistage historic landslides.
Relationship between structural and social dimensions of school culture
Authors: Čamber Tambolaš Akvilina , Vujičić Lidija , Jančec Lucija
Published: January 2023

The culture of an educational institution is defined as a set of common beliefs and values that closely connect the members of a community. Structural dimensions (space, time, teaching materials, and teaching strategies), social dimensions (relationships among school staff, between teachers and children, and among children), common rituals, and customs and traditions of the school are manifestations of school culture in which it is recognized and becomes visible. The aim of this research is to determine the connection between structural dimensions and social relations in the institution. The research was conducted in 2022 on a sample of 174 primary teachers employed in various schools in the Republic of Croatia. The Questionnaire for the Assessment of the Culture of the Educational Institution was used for data collection. An exploratory factor analysis on the Scale of the State of School Culture, which measured the state of structural dimensions, extracted two factors, based on which two subscales of good metric characteristics were created: organization of educational work and spatial and temporal dimensions. The Scale of the State of Relations in the Institution consists of 13 items and has high reliability. In order to determine the existence of a connection between the structural and social dimensions of school culture, Pearson's correlation coefficients were calculated. Moderate to relatively high positive correlations between the examined variables were found, which confirms the intertwining and interdependence of different dimensions of school culture, which significantly determines the quality of life and education of children in the institutional context.
Galanin family peptides: Molecular structure, expression and roles in the neuroendocrine axis and in the spinal cord
Authors: Zhu Sipin , Hu Xiaoyong , Bennett Samuel , Charlesworth Oscar , Qin Shengnan , Mai Yuliang , Dou Haicheng , Xu Jiake
Published: January 2023

Galanin is a neurohormone as well as a neurotransmitter and plays versatile physiological roles for the neuroendocrine axis, such as regulating food intake, insulin level and somatostatin release. It is expressed in the central nervous system, including hypothalamus, pituitary, and the spinal cord, and colocalises with other neuronal peptides within neurons. Structural analyses reveal that the human galanin precursor is 104 amino acid (aa) residues in length, consisting of a mature galanin peptide (aa 33-62), and galanin message-associated peptide (GMAP; aa 63-104) at the C-terminus. GMAP appears to exhibit distinctive biological effects on anti-fungal activity and the spinal flexor reflex. Galanin-like peptide (GALP) has a similar structure to galanin and acts as a hypothalamic neuropeptide to mediate metabolism and reproduction, food intake, and body weight. Alarin, a differentially spliced variant of GALP, is specifically involved in vasoactive effect in the skin and ganglionic differentiation in neuroblastic tumors. Dysregulation of galanin, GALP and alarin has been implicated in various neuroendocrine conditions such as nociception, Alzheimer’s disease, seizures, eating disorders, alcoholism, diabetes, and spinal cord conditions. Further delineation of the common and distinctive effects and mechanisms of various types of galanin family proteins could facilitate the design of therapeutic approaches for neuroendocrine diseases and spinal cord injury.
Accelerating transmission-constrained unit commitment via a data-driven learning framework
Authors: Lin Zhaohang , Chen Ying , Yang Jing , Ma Chao , Liu Huimin , Liu Liwei , Li Li , Li Yingyuan
Published: January 2023

As a fundamental task in power system operations, transmission-constrained unit commitment (TCUC) decides ON/OFF state (i.e., commitment) and scheduled generation for each unit. Generally, TCUC is formulated as a mixed-integer linear programming (MILP) and must be resolved within a limited time window. However, due to the NP-hard property of MILP and the increasing complexity of power systems, solving the TCUC within a limited time is computationally challenging. Regarding the computation challenge, the availability of historical TCUC data and the development of the machine learning (ML) community are potentially helpful. To this end, this paper designs an ML-aided framework that can leverage historical data in enabling computation improvement of TCUC. In the offline stage, ML models are trained to predict the commitments based on historical TCUC data. In the online stage, the commitments are quickly predicted using the well-trained ML. Furthermore, a feasibility checking process is conducted to ensure the commitment feasibility. As a result, only a reduced TCUC with fewer binary variables needs to be solved, leading to computation acceleration. Case studies on an IEEE 24-bus and a practical 5655-bus system show the effectiveness of the presented framework.
Impact of plug-in electric vehicles on grid integration with distributed energy resources: A review
Authors: Dharavat Nagaraju , Golla Naresh Kumar , Sudabattula Suresh Kumar , Velamuri Suresh , Kantipudi M. V. V. Prasad , Kotb Hossam , AboRas Kareem M.
Published: January 2023

The rise of electric vehicles (EVs) has a massive impact on the electricity grid due to the electrification of vehicles in the transportation sector. As a result, various techniques are needed to minimize the effects of charging on the grid. One of these techniques is having intelligent coordination between the various components of the EV charging network. This ensures that the network has enough electricity to support the charging needs of the vehicles. This article provides an overview of the many aspects of the EV industry and its charging infrastructure. It also provides a step-by-step approach for implementing the Vehicle to Grid (V2G) deployment, the utilization of recordings from the data by the EV battery through Artificial Intelligence and the cost-benefit analysis from effective utilization of the V2G method. The paper also explores the various aspects of the EV market and the role of aggregators and consumers. Finally, it assesses the possibility of expansion of the EV charging and grid integration system and outlines its challenges and solutions.
Calculation of renewable energy hosting capacity of distribution network based on multi strategy improved adaptive manta ray foraging optimization
Authors: Yuan Zhiyong , Xu Min , Tao Yigang , Li Min , Guo Zuogang , Zhang Juncheng
Published: January 2023

With the increasing penetration of renewable energy in the distribution network, however, due to the randomness and volatility of renewable energy output, the large-scale grid connection of renewable energy will bring challenges to the safe and stable operation of the distribution network. The calculation of renewable energy hosting capacity of distribution network is not only beneficial to the construction of renewable clean and low-carbon power system, but also of great significance for the planners of power grid to carry out renewable energy planning. Renewable energy hosting capacity calculation involves many constraints, including a large number of nonlinear constraints, and the hosting capacity calculation model is very complex, lacking efficient solution algorithm. Aiming at the existing problems, the calculation model of renewable energy hosting capacity of distribution network is established based on full consideration of power quality, relay protection and thermal stability test. A multi strategy improved adaptive manta ray foraging optimization algorithm (MSAMRFO) is proposed to solve the hosting capacity model. MSAMRFO algorithm adopts half uniform initialization strategy, adaptive variable step size strategy and local convergence mutation strategy to improve manta ray foraging optimization algorithm (MRFO) algorithm. Finally, the effectiveness of the proposed model and method is verified by an example. The example shows that the MRFO algorithm after multi strategy improvement has outstanding effect both in convergence speed and algorithm stability.
Characteristics of the soil arbuscular mycorrhizal fungal community along succession stages in tropical forest and its driving factors
Authors: Mai Siwei , Mao Han , Jiang Yamin , Huang Ting , Yang Qiu , Xing Guitong , Wang Xiaofang , Yang Huai , Liu Wenjie
Published: January 2023

Arbuscular mycorrhizal fungi play an important role in mediating plant-soil interactions across succession stages. However, AMF community dynamics which about the change of community composition and member activity remain unclear. To complete the gap knowledge about microbial community dynamics during restoration succession, soil AMF community composition was studied within a tropical forest ecosystem in the Ganshiling nature reserve using high throughput sequencing methods. The results revealed that soil AMF communities characteristics about speices diversity, species composition and microbial correlation network showed significant differences between shrubland (SC) and secondary forest ecosystems, but the same differences were not found between 40-year recovery secondary forest (SF40) and 60-year recovery secondary forest (SF60). Plant community dynamics were the key factor for regulating soil AMF communities among succession stages. An important biotic factor explaining variance in AMF community composition was root biomass. The correlation network analysis showed that although the nodes were similar among succession stages, the complexity of networks was significant higher in SF40 than in SC and SF60, suggesting that AMF communities were more active in SF40, which verified the hypothesis of intermediate disturbance hypothesis. This study provides new insights into AMF community dynamics and their driving factors across succession stages, as well as expanding knowledge of the ecological value of AMF for tropical forest restoration processes.