bluuebunny/crossref_metadata_2025 huggingface dataset:
Population’s perceptions and availability of primary care services in Romania- a pilot survey in County Brasov.
Authors: Neculau Andrea Elena , Rogozea Liliana , Popa Daniela , Atudorei Ioana , Leasu Florin , Moga Marius Alexandru , Lacatus Anca
Published: December 2019

Background National health reports on Romania show that decisions in healthcare planning are not correlated with the health needs of the population and that there is a high degree of unmet healthcare needs of the population (related to cost, distance and waiting times), especially for low-income populations. Family medicine is facing underfinancing, slow pace of development. Methods The research is part of a wider project of health services needs assessment in county Brasov, Romania. A subset of questions where dedicated to identifying the perception of population on primary healthcare services. Comparison with previous national and international studies was done. Results The characteristics of the population questioned: predominantly women (67.2%), 61.1% graduates of high school or other professional schools. 97.4% are registered with a FD. The average number of visits at the FD is 11.25, higher than the national average of 7.7 reported in a previous study in 2009. Access to the FD is appreciated as satisfactory in terms of availability of doctors in the community (97.4%), opening times by (91.1%), phone access (90.5%). Only 26.6% of participants reported a same day opportunity to reach the FD. Continuity of care is reported as present in 58.7% of cases in out of hours centres. The population is appreciating the fact that FDs knows their history (90%), knows how to treat them (88.2%). Most of the preventative services are offered by FDs. 94.4% flu vaccination, 85.6% pregnancy monitoring, 90.7% well child visits. Procedures like blood draws, pap smear have less availability (46.2% respectively 63.1%). Conclusions Despite limitations in the practice of family medicine in Romania and therefore a narrow spectrum of services offered by primary care in general, the level of contentment of the population with this healthcare resource is still high. Barriers to access are related to the lack of some essential services, especially preventive and out-of-hours services. Research at national level should be done in order to better categorize population’ perceptions on primary care and be able to use their opinion to influence policies and healthcare planning. Key words: unmet health needs, population’s perception, primary care, Romania
Comparison of First-line Pazopanib and Sunitinib in Metastatic Renal Cell Carcinoma: Experiences of the Urologic Cancer Centre for Research and Innovation
Authors: Wong Emily C.L. , Tajzler Camilla , Vasisth Gaurav , Zhu Amanda , Chow Mathilda , Lovatt Catherine , Hotte Sebastien , Kapoor Anil
Published: December 2019

Background: Sunitinib and pazopanib are orally-administered tyrosine kinase receptor inhibitors (TKIs) approved as first-line therapy for the treatment of metastatic renal cell carcinoma (mRCC). The IMDC criteria are a predictive prognostic model for patients with mRCC when stratified into three prognosis groups: favourable, intermediate and poor. We retrospectively compared the efficacy and safety of sunitinib and pazopanib as first-line therapy for patients with mRCC in our single institution database. Methods: Retrospective analysis was done to compare progression-free survival (PFS) and side effects of sunitinib and pazopanib as first-line therapy in patients with mRCC. Patients were stratified into prognosis groups according to IMDC criteria. Disease assessment was performed on measurable aspects of disease based on computed tomography or magnetic resonance imaging reports. Survival analysis was performed using the Kaplan-Meier method and Cox regression, with disease progression as the endpoint.Results: Data was obtained from 228 patients with mRCC who were treated with either pazopanib (n=57) or sunitinib (n=171). No significant difference in PFS was found between sunitinib and pazopanib (HR for disease progression or all-cause death, 1.10; 95%CI: 0.76-1.57, p=0.62). Median PFS time for patients receiving sunitinib was 9.4 months and for pazopanib, 8.5 months. Median PFS for patients with intermediate-risk disease was similar between groups (9.4 months vs. 9.2 months, respectively, p=0.93). However, patients treated with sunitinib experienced a greater number of side effects compared to pazopanib. Conclusions: Sunitinib and pazopanib are similarly efficacious as first-line therapy for mRCC. However, adverse events are lower with pazopanib.
Combined impact of lifestyle factors on low back pain: A cross-sectional study of over 400,000 Japanese adults
Authors: Yoshimoto Takahiko , Ochiai Hirotaka , Shirasawa Takako , Nagahama Satsue , Uehara Akihito , Muramatsu Jun , Kokaze Akatsuki
Published: December 2019

Background: Many epidemiological studies have indicated the association between low back pain (LBP) and lifestyle factors, such as physical activity, smoking, weight gain, diet, and sleep problems. However, the combined effect of lifestyle factors on LBP has not been adequately investigated. Thus, we aimed to investigate the association between a cluster of unhealthy lifestyle behaviors and LBP using a large cohort of Japanese adults.Methods: We included 419,003 adults aged over 20 years who underwent an annual health checkup between April 2013 and March 2014 in Japan. Information on the following lifestyle factors were collected using the standardized questionnaire recommended by the Ministry of Health, Labour and Welfare in Japan: smoking, alcohol intake, exercise, physical activity, walking speed, weight control, eating habits, and sleep. Each factor was evaluated as a dichotomous variable (1: health risk, 0: no health risk). A lifestyle risk score was calculated by summing the score of each lifestyle factor (range: 0-12) and was categorized into three groups (low, moderate, high). LBP was defined as self-reported LBP under treatment. Logistic regression analysis was conducted to calculate the odds ratio (OR) and 95% confidence interval (CI) for LBP.Results: In multivariate logistic regression analysis, the OR for LBP was significantly higher in the moderate risk score group (adjusted OR: 1.33 [95% CI: 1.23-1.44] in men; 1.40 [95% CI: 1.27-1.54] in women) and the high risk score group (adjusted OR: 1.54 [95% CI: 1.43-1.67] in men; 1.83 [95% CI: 1.64-2.03] in women) than in the low risk score group. A trend of higher risk of LBP associated with higher lifestyle risk score was observed in both sexes (p for trend < 0.001). These results were similar even in subgroup analysis by age (20-39, 40-59, and ≥ 60 years) and body mass index (BMI) (< 18.5, 18.5-24.9, and ≥ 25 kg/m2).
Transcriptome sequencing and anthocyanin metabolite analysis determines leaf color of Acer pseudo-sieboldianum in autumn
Authors: Zhao Donghui , Gao Yufu , Rong Liping
Published: December 2019

Background: Acer pseudo-sieboldianum is an often used color-leafed tree native to northeastern China, whose leaves are gorgeous in autumn and is used to great effect in landscaping. Leaf color is an important index affecting the ornamental traits of color-leafed plants. Thus, it is of great significance to study the mechanism in leaf coloring in Acer pseudo-sieboldianum as the development and application prospects of this research are broad, and further the utilization of local characteristics tree species with colored leaves. Results: In this study, the leaves of Acer pseudo-sieboldianum from three stages in the autumn color-changing period were used as materials. In order to investigate the related differentially expressed genes in the process of color transformation, we determined the anthocyanins in leaves and used high-throughput sequencing to analyze the associated transcriptomes. The results demonstrated that five anthocyanins were detected in this experiment. It is worth mentioning that Peonidin O-hexoside, Cyanidin 3-O-glucoside (Kuromanin) and Cyanidin 3,5-O-diglucoside (Cyanin) have significant differences in their content change in two of the tested periods, meaning these may be the key substances determining the final color of Acer pseudo-sieboldianum. A total of 67.47 Gb of clean data were obtained from our sequencing results. Functional annotation of unigenes, including comparison with COG and GO databases, yielded 35,316 unigene annotations. 16521 differentially expressed genes were identified from a statistical analysis of differentially gene expression. We were able to cluster genes related to leaf color formation in Acer pseudo-sieboldianum, including ANS, DFR, F3H, UFGT, and so on, based on the expression at specific times. Conclusions: This study enriched the available transcriptome information for Acer pseudo-sieboldianum and identified a series of differentially expressed genes related to leaf color, which provides valuable information for further study on the genetic mechanism of leaf color expression in Acer pseudo-sieboldianum.
Automatic extraction, prioritization and analysis of gut microbial metabolites from biomedical literature
Authors: Wang Quangqiu , Xu Rong
Published: December 2019

Background: Many diseases are driven by gene-environment interactions. One important environmental factor is the metabolic output of human gut microbiota. A comprehensive catalog of human metabolites originated in microbes is critical for data-driven approaches to understand how microbial metabolism contributes to human health and diseases. Here we present a novel integrated approach to automatically extract and analyze microbial metabolites from 28 million published biomedical records. Results: First, we classified 28,851,232 MEDLINE records into microbial metabolism-related or not. Second, candidate microbial metabolites were extracted from the classified texts. Third, we developed signal prioritization algorithms to further differentiate microbial metabolites from metabolites originated from other resources. Finally, we systematically analyzed the interactions between extracted microbial metabolites and human genes. A total of 11,846 metabolites were extracted from 28 million MEDLINE articles. The combined text classification and signal prioritization significantly enriched true positives among top: manual curation of top 100 metabolites showed a true precision of 0.55, representing a significant 38.3-fold enrichment as compared to the precision of 0.014 for baseline extraction. More importantly, 29% extracted microbial metabolites have not been captured by existing databases. Our data-driven analysis of the interactions between the extracted microbial metabolite and human genetics provides mechanistic insights into how microbiota may contribute to human diseases. Conclusions: This study represents the first effort towards building a comprehensive knowledge base of microbial metabolites, which can set the foundation for future tasks of microbial metabolite relationship extraction from literature and facilitate data-driven studies of how microbial metabolism contributes to human diseases.
The effect of pyridine-alkaloid secondary metabolites on sunbirds gut microbiome
Authors: Gunasekaran Mohanraj , Lalzar Maya , Sharaby Yehonatan , Izhaki Ido , Halpern Malka
Published: December 2019

Background: Sunbirds (Cinnyris osea) feed on nectar of the tobacco tree (Nicotiana glauca), which contains the secondary metabolites nicotine and anabasine. These toxic pyridine-alkaloids presumably serve to deter nectar thieves and allow only specific pollinators to feed on nectar. The floral nectar contains low level of proteins and hence nectarivores may have problem balancing their nitrogen requirements. Our aim was to understand whether the gut microbiome of nectarivores contains bacteria that are able to degrade plant secondary metabolites and how the presence of secondary metabolites in nectar shapes the gut microbiome of nectarivores.Results: Sunbirds (n=16) that were held in captivity were randomly divided into control and treatment groups. The control group was fed with artificial nectar while the treatment group was fed with artificial nectar with the addition of nicotine and anabasine. Excreta were collected from each of the 16 birds on day 0 and at the end of weeks 2, 4 and 7. Nonmetric multidimensional scaling analysis (nMDS) demonstrated that the secondary metabolites significantly changed the gut microbiota composition and diversity of those sunbirds that were fed nectar with added pyridine alkaloids. Aeromonas, Enterobacteriaceae, Exiguobacterium, Klebsiella, Lactococcus, Leuconostoc, Rothia and Salmonella were found to contribute to the differences in gut microbiota between the control and treated birds (birds feed with Nicotine and Anabasine). Four weeks after starting to feed the birds with added nicotine and anabasine, we found that genera with the ability to degrade these pyridine-type metabolites proliferated from a total relative abundance of only 0.3% to 52.7% of the gut bacterial community.Conclusion: Sunbirds feed on Nicotiana nectar that contains toxic pyridine-alkaloids. Nonetheless, the symbiotic gut microbiota which is changing dynamically towards enabling the degradation of these secondary metabolites, supply the birds with nitrogen that enables the synthesis of essential amino acids. The current study contributes to our understanding of the complex relationships between plants, birds and their microbiomes.
miR-373-3p inhibits EMT via regulation of TGFβR2 in choriocarcinoma
Authors: lu yanjie , Li Xiaoru , Zuo Yanzhen , xu qian , liu lei , wu haiying , chen long , zhang ying , fan wenjing , liu ying , li yuhong
Published: December 2019

Background: Previous studies have indicated that early metastasis is a major cause of mortality in patients with choriocarcinoma. However, what determines whether early metastasis of choriocarcinoma has occurred is unknown. The emerging role of miRNA in regulating cancer development and progression has been recognized. MiR-373-3p has been shown to play pivotal roles in tumorigenesis and metastasis. However, whether miR-373-3p functions to promote choriocarcinoma metastasis is not clear. The purpose of this study is to determine the function of miR-373-3p in the progression of choriocarcinoma. Methods: In this study, we first compared EMT-related markers, which are inversely correlated with miR-373-3p expression, in trophoblast and choriocarcinoma cell lines. Using PCR and western blot, the upregulation of miR‑373‑3p was observed to inhibit EMT progression. Similarly, gain-and loss-of-function studies revealed that ectopic miR-373-3p overexpression inhibited the metastasis of choriocarcinoma cells. Results: Our results revealed that miR-373-3p functions as an inhibitor in JEG-3 and JAR cells; this is due to its mediation of the TGF-β signalling pathway, which is responsible for EMT. The bioinformatic analysis and dual‑luciferase reporter gene assays were employed to verify that miR‑373‑3p might interact with the 3' untranslated region of TGFβR2 mRNA. Further western blot results showed miR‑373‑3 preversed the increases of TGFβR2 and inhibited EMT. Conclusions: In light of our observations, miR‑373‑3p upregulation partly accounts for TGFβR2 downregulation and leads to a restraint of EMT and metastasis. MiR‑373‑3p may, therefore, serve as a valuable target in potential anticancer strategies to treat choriocarcinoma.
The utility of six serum tumor markers in early detection of lung cancer
Authors: Jiang Qingwen , Zheng Xu , Li Yiting , Huang Weina , Li Xinjian , Cao Chao
Published: December 2019

Background: Lung cancer has become the leading cause of cancer-related death in China. However, most of patients were diagnosed at advanced stage. Thus, novel lung cancer diagnostic tests, which can be used to screen individuals in early stage, are required.Methods: A total of 208 patients involving 161 cases of lung cancer and 47 cases of benign diseases were enrolled. Serum concentration of GTM, CETM, PTM, CTM, ETM and HTM were analyzed by kits according to the manufacturer’s guidelines.Results: The results showed significant difference in serum concentrations of GTM, CETM, PTM, CTM, ETM, and HTM between patients with lung cancer and benign diseases. In addition, when compared with benign diseases, higher levels of those six markers were also observed in patient with SCC and SCLC, but not for ADC. Receiver operating characteristic (ROC) curves were further suggested a high sensitivity and specificity of six markers to identify lung cancer.Conclusion: The serum levels of GTM, CETM, PTM, CTM, ETM and HTM in lung cancer were significantly higher than those of benign diseases. Moreover, these six biomarkers showed a high sensitivity and specificity to identify a patient with malignant. These findings suggested that detection of those six biomarkers in serum might be helpful for differential diagnosis of lung cancer.
Expression of selected MicroRNAs in pancreatic ductal adenocarcinoma in relation to tumor progression and patient’s outcome.
Authors: Popov Alexey , Szabo Arpad , Gurlich Robert , Liberko Marian , Soumarova Renata , Vernerova Zdenka , Mandys Vaclav
Published: December 2019

Background: pancreatic ductal adenocarcinoma (PDAC) remains a disease with extremely poor prognosis and limited effective available treatment. Differential expression of miRNAs isolated from tumor tissue has been proposed as a marker for tumor diagnosis, progression and prognosis. Nevertheless, prognostic value of miRNAs expression in PDACs for patient outcome still remains unclear.Methods: expression of 7 selected miRNAs, isolated from FFPE samples of 54 PDAC patients, was quantified using RT-qPCR. The relationship of miRNA expression levels with tumor histology, clinico-pathological characteristics, patient overall survival (OS) and progress-free survival (PFS), was subsequently evaluated.Results: overexpression of miR-21, miR-155 and miR-210 was observed in PDACs (up to 72.62-fold, 232.36 and 181.38-fold respectively), in comparison with non-neoplastic tissues. On the other hand, miR-96 and miR-217 were significantly downregulated in PDACs (up to one hundred times). No differences were, however, noticed between cancer and normal tissues for the expression levels of miR-148a and miR-196a.On the other hand, expression levels of all 7 miRNAs failed to demonstrate significant correlation with parameters of tumor progression, such as tumor stage, grade, nodal involvement, perineural and vascular invasion. Positive correlation of miR-210 levels was, however, observed with patient age (ρ=0.35). Additionally, miR-148a and miR-217 expression have shown positive association with tubular tumor growth pattern (ρ=0.39; ρ=0.28). Negative correlation of miR-148a values was also demonstrated with dissociative growth pattern and nuclear atypia (ρ=-0.30; ρ=0.27).
MODELOS DE REGRESSÃO LINEAR MÚLTIPLA PARA OBTENÇÃO DE PROPRIEDADES ELÁSTICAS DOS AGREGADOS LEVES EM CONCRETOS
Authors: Garcia Pedro Henrique , Da Fonseca Leonardo Goliatt , Bastos Flávia de Souza
Published: December 2019

A determinação do módulo de elasticidade de um material é um paramêtro importante quando se pretende estudar suas propriedades elásticas. Em se tratando dos agregados leves, utilizados para composição dos concretos leves, a determinação do módulo de elasticidade dos agregados tem sido um desafio, função da sua dimensão reduzida e formato, o que causa dificuldades na realização de ensaios experimentais. Pelo fato dos agregados leves utilizados em concretos estruturais serem produzido industrialmente e não possuir uma rocha matriz, não existem ensaios de carga normalizados e as formulações encontradas na literatura divergem umas das outras. É possível encontrar formulações matemáticas na literatura para obter o módulo de elasticidade do agregado leve por meio de diferentes métodos, porém a limitação é que as formulas são complexas ou só levam em conta a densidade da partícula, podendo não representar a realidade e não considerar as diferentes interações do material com a argamassa. O objetivo do trabalho é obter formulações matemáticas do módulo de elasticidade dos agregados por meio de propriedades elásticas do concreto e da argamassa envoltos nos agregados, aplicando uma regressão linear multípla. Além disso, é possível encontrar no artigo um estudo paramétrico das relações entre os diferentes agregados leves, argamassas e concretos.
SISTEMA CONSULTÓRIO PARA ESCOLHA DE FILTRO IDEAL NA INDUSTRIA QUÍMICA (SCEF)
Authors: Zuba Parrela Renan , Jorge Shara Katerine Moreira
Published: December 2019

O foco de estudantes e pesquisadores de filtração não está na seleção dos equipamentos adequados para o processo, mas no estudo de parâmetros intrínsecos da torta formada durante os ensaios de filtração para posterior dimensionamento do filtro. Essa seleção dos utensílios adequados é um domínio de praticantes de filtração, especialistas que realizam experimentos exaustivos e que, por conseguinte, possuem conhecimento heurístico para escolhas. Este trabalho delineou a confecção de protótipo de um sistema baseado em conhecimento para seleção do filtro ideal (SCEF) baseando-se em certas abstrações. O protótipo não substitui uma análise minuciosa de filtração, mas pode ser utilizado em âmbito acadêmico, para fins didáticos, e por engenheiros químicos de pouca experiência como uma estimativa inicial na seleção do filtro ideal.
SISTEMA DE SECAGEM VIA ENERGIA SOLAR E ACUMULADOR DE CALOR PARA AMÊNDOAS DE CACAU
Authors: Sales Jorge Henrique , Soglia Luiz Vinicius , Girotto Pedro Sales
Published: December 2019

A forma tradicional de secagem das amêndoas do cacau ocorre através das barcaças: estruturas de madeira ou alvenaria onde as amêndoas são dispostas e a secagem acontece por incidência solar direta. Durante o período noturno, ou de baixa incidência solar, utiliza-se o calor proveniente da queima de combustíveis para a secagem. Porém essa queima gera resíduos que contaminam as amêndoas, diminuindo o seu valor comercial e a sua aceitação no mercado. O objetivo deste trabalho foi desenvolver um sistema que capte a energia solar através de uma série de espelhos semicilíndricos e transfira o calor para um tanque acumulador contendo NaCl sólido. A energia térmica acumulada é utilizada para aquecer um fluxo de ar durante o período noturno, que realizará uma secagem uniforme e limpa das amêndoas de cacau. As simulações do sistema foram realizadas no software COMSOL Multiphysics® e demonstraram que, para a incidência solar média de Ilhéus-BA, são necessários seis espelhos semicilíndricos de 0,30 m de diâmetro por 1,00 m de comprimento cada, dispostos sequencialmente, para aquecer e manter a temperatura em torno de 50 °C no período diurno, demonstrando que este sistema pode fornecer adequadamente a energia térmica necessária para a secagem das amêndoas dentro da faixa ideal de temperatura.
ABORDAGEM MULTIOBJETIVA EM CARTEIRAS UTILIZANDO ALGORITMOS EVOLUTIVOS: UMA ANÁLISE EMPÍRICA ENVOLVENDO RETORNO E ASSIMETRIA
Authors: Gotardelo Davi Riani , Fonseca Leonardo Goliatt
Published: December 2019

Este artigo visa comparar o desempenho de quatro algoritmos evolutivos em otimização multiobjetivo aplicados a um problema na área de Finanças: seleção de carteiras. Os algoritmos multiobjetivos NSGAII, MOEAD, IBEA e GDE3 foram usados para otimizar simultaneamente o retorno médio da carteira, bem como sua assimetria. Os dados coletados nesta pesquisa foram relativo às empresas listadas no Índice Dow Jones e foi feita a análise das carteiras ótimas de cada algoritmo no período dentro (2010 - 2014) e fora da amostra (2015 - 2017). Testes estatísticos mostraram que o algoritmo GDE3 apresentou o melhor desempenho dentro e fora da amostra.
ANÁLISE MULTIVARIADA DE TEMPO, TEMPERATURA E AGITAÇÃO NA TRANSFERÊNCIA DE MASSA DO CLORETO DE SÓDIO EM ÁGUA
Authors: Aguiar Polyana Gomes de , Fernandes João Paulo Silva , Magalhães Mariana Cordeiro , Dias Daiane Ribeiro , Andrade Isabelle Santos , Gonçalves João Carlos , Cardoso Thalles de Assis Gonçalves
Published: December 2019

O transporte difusivo e convectivo são essenciais para a transferência de massa nas reações químicas e a sua eficácia pode variar conforme alguns fatores relevantes nas construções de unidades industriais. As variáveis de um sistema podem influenciar diretamente no processo, sendo assim, tornam-se válidas as suas análises, a fim de se encontrar condição ótima de operação.  Feita essa consideração, no presente trabalho realizou-se o planejamento fatorial de preparo da solução de cloreto de sódio com intuito de realizar tratamento estatístico dos resultados obtidos para condutividade do sistema quando a agitação, temperatura e tempo assumiram valores em dois níveis de estudo. A partir da realização de 8 (oito) experimentos em triplicata foi possível obter a média de condutividade para cada ensaio e, assim, gerar o Gráfico de Pareto, Modelo de regressão múltipla, teste de significância da regressão, Superfícies de Resposta e Parâmetros F e p. Observou-se que a variável temperatura e a sua combinação com a agitação podem ser consideradas significativas na transferência de massa e, devido ao fato das suas interferências serem lineares, valores máximos dessas propriedades podem ser considerados pontos ótimos. No caso dessa aplicação, o ponto ótimo se deu em temperatura de 60°C.
PROPOSTA DE METODOLOGIA PARA ANÁLISE DO EFEITO DE BRANQUEAMENTO DO PVDF ATRAVÉS DO PROCESSAMENTO DE IMAGENS
Authors: Teixeira Carlos Adriano Arruda , Silva Simone Vasconcelos
Published: December 2019

Para tornar possível a exploração de óleo e gás natural em águas marítimas é necessário desenvolvimento de alta tecnologia para dar suporte aos projetos de perfuração e exploração de poços submarinos. Um dos equipamentos que viabiliza a exploração off-shore é o duto flexível. As linhas de dutos flexíveis possuem um complexo e meticuloso processo produtivo, devido à tecnologia de ponta envolvida em seu método de construção. Considerando o alto custo e a complexidade do processo de fabricação de dutos flexíveis, é objetivo deste trabalho é propor uma metodologia para análise do efeito do branqueamento em polifluoreto de vinilideno (PVDF) utilizado em linhas flexíveis da indústria de petróleo através do processamento de imagens. A metodologia consiste em etapas (análise do problema, criação do banco de imagens, tratamento das imagens e análise dos resultados) que contemplam o estabelecimento de critérios de aceitação com base no entendimento da causa raiz, amostragem e testes. Como resultado espera-se a aquisição e processamento de imagens para estabelecer os padrões visuais que podem ser aceitáveis quando há ocorrência de branqueamento. Em trabalhos futuros espera-se elaborar uma ferramenta, baseada na metodologia proposta, que avalie através de aquisição e processamento de imagens os branqueamentos que venham a ocorrer no processo de manufatura com base em padrões de imagens.
The dynamic nexus between climate changes, agricultural sustainability and food-water poverty in a panel of selected MENA countries
Authors: Jemmali Hatem , Morrar Rabeh , Ben Aissa Mohamed Safouane
Published: December 2019

This study attempts to examine the dynamic relationships between climate changes, agricultural sustainability and food-water poverty in a panel of MENA countries over the period 1990–2016. A panel co-integration, pooled least squares regression, pooled fixed effects, and pooled random effects models with the Hausman test for model specification are used to relate three proxies for food poverty and two proxies for water poverty to standard weather variables, agriculture productivity indicators, and environmental sustainability variables. The main results of regression analysis indicate that out of the three food poverty models, two food poverty regressions indicate the low agricultural productivity in low- and middle-income countries, while water poverty in terms of access to improved water is found to increase substantially agricultural value added (coefficient is more elastic, i.e. more than the unity). The results further show that high precipitation and temperature, often accompanied by high CO2 emissions, increase food poverty in terms of food deficit and prevalence of undernourishment, whilst having no significant effect on water poverty. The overall findings conclude that there is a substantial requirement to increase agricultural sustainability in low- and middle-income MENA countries without deteriorating environment and water reserves.
Structural Modifications on CORM-3 Lead to Enhanced Anti-angiogenic Properties Against Triple-negative Breast Cancer Cells
Authors: Kourti Malamati , Cai Jun , Jiang Wen , Westwell Andrew D.
Published: December 2019

Purpose:

Carbon monoxide-releasing molecules (CORMs) are a special class of organometallic
complexes that have been reported to offer beneficial effects against different conditions
including several subtypes of cancer. Especially for the aggressive and poorly treated triplenegative
breast cancer (TNBC), early CORMs have been shown to diminish malignant angiogenesis
and may be considered as an alternative approach. So, this study aimed at testing novel CORM
molecules against angiogenesis in TNBC seeking potent drug candidates for new therapies.

Methods:

Based on previous studies, CORM-3 was chosen as the lead compound and a group of
15 new ruthenium-based CORMs was synthesized and subsequently evaluated in vitro for potential
anti-angiogenic properties.

Results:

A similar anti-angiogenic behaviour to the lead complex was observed and a new CORM,
complex 4, emerged as a promising agent from this study. Specifically, this complex offered better
inhibition of the activation of VEGFR2 and other downstream proteins of vascular endothelial
cells. Complex 4 also retained the ability of the parent molecule to reduce the upregulated VEGF
expression from TNBC cells and inhibit endothelial cell migration and new vessel formation. The
lack of significant cytotoxicity and the downregulating activity over the cytoprotective enzyme
haem oxygenase-1 (HO-1) in cancer cells may also favour CORMs against this poorly treated subtype
of breast cancer.

Conclusions:

Since the anti-angiogenic approach is one of the few available targeted strategies
against TNBC, both CORM-3 and the new complex 4 should be considered for further research as
combination agents with existing anti-angiogenic drugs for more effective treatment of malignant
angiogenesis in TNBC.
Digital marketing as promotion on Bali jeep adventure products
Authors: Sari Putu Ratna Juwita
Published: December 2019

Bali is one of the famous tourist destinations in the world, so there are many tourism actors offering tourism service and products to tourists who visit. One of the service providers in the form of a tour program is Bali Jeep Adventure which offers a back to nature program using a special 4WD car. Along with the development of technology and information, the marketing must be done through modern means, namely digital marketing using the internet. There are three main stages that must be carried out by Bali Jeep Adventure to maximize promotions through digital means, namely traffic, conversion, and engagement. This research uses qualitative descriptive methods, taking informants with purposive sampling and used triangulation of data aimed at obtaining data validity.
Church efforts on strengthening women capacity to fight household violence in Kupang
Authors: Dethan Mesakh Abia Pello , Doeka Fredrik Y. A. , Mansopu Leni Hanna Flolinda , Laki Rinto Rame
Published: December 2019

This research aims to investigate how far handling of the Christian Evangelical Church in Timor (GMIT) Efata Liliba against violence in the household (KDRT) occurring in women, which can be used as a study and learning materials in preventing and overcoming violence against women. The method used in this research is a qualitative method of research. The qualitative approach of research is chosen because it emphasizes the phenomenon/fact, the meaning of reasoning, certain situations (in certain contexts), or more researching matters relating to the daily life of women who become the victim of violence in a household (KDRT). From the results of the study found that the factors causing the violence in the household (KDRT) because of economic pressures, husbands are average drunkard and love to gamble. The profession of the wife as a housewife and only relies economically on husbands who are drunkard and love to gamble cause violence in a household as if it gets a fertile place. The efforts of GMIT Efata Liliba by strengthening the capacity of women to fight the violence in the household through the economic empowerment of women in the local church is apparently fruitful results. The woman who is economically strong and her mentality is able to dampen the acts of violence in the household.
Influence of self-assessment system, taxation understanding, and discrimination toward ethics of tax evasion
Authors: Seralurin Yohanes C. , Ermawati Yana
Published: December 2019

The main principle of tax collection, as a manifestation of the obligation of citizens, is to help state finance and national development. All state income from taxes will be used to finance all public expenses, which means that it is used to improve the welfare of the people. As regulated in the provisions of Law Number 16 Year 2009 article 1 paragraph 1, all people who according to the law are included as taxpayers must pay taxes according to their obligations. Unfortunately, tax evasion has been a phenomenon that was committed to avoid taxes. Therefore, the public should be aware of the self-assessment system, understanding taxation, and discrimination regarding the ethics of tax evasion. The purpose of this study was to determine and analyze the effect of the self-assessment system, understanding taxation, and discrimination towards the ethics of tax evasion. The population in this study were all taxpayers in the Jayapura Primary Tax Office.
Techniques used to formulate confidential data by means of fragmentation and hybrid encryption
Authors: Beckham Olly , Oldman Gord , Karrie Julie , Craig Dorth
Published: December 2019

Cloud computing is a concept shifting in the approach how computing resources are deployed and purchased. Even though the cloud has a capable, elastic, and consistent design, several security concerns restrain customers to completely accept this novel technology and move from traditional computing to cloud computing. In the article, we aspire to present a form of a novel architectural model for offering protection to numerous cloud service providers with the intention to devise and extend security means for cloud  computing. In this work, we presented a two-tier architecture for security in multi-clouds; one at the client side, and other at the server side. The article presented a security domination outline for multi-clouds and supports security needs like Confidentiality, Integrity, Availability, Authorization, and Non-repudiation for cloud storage. Through this document we have anticipated, HBDaSeC, a secure-computation protocol to ease the challenges of enforcing the protection of data for information security in the cloud.
Effect of transformational leadership and compensation on employee performance
Authors: Diantari Ni Putu Astrimita , Riana I Gede
Published: December 2019

A leader is a person who has the skills and strengths so as to be able to influence others to carry out certain activities, for the achievement of goals. This study aims to analyze the effect of compensation and transformational leadership on employee performance. Using a sample of 76 employees at PT. Raditya Perkasa, this study used a questionnaire as the main instrument. The collected data were analyzed using multiple linear regression using SPSS 20. The results showed that compensation and transformational leadership had a significant positive effect on employee performance. Partially, this study found that transformational leadership has a stronger effect on employee performance compared to compensation. Furthermore, the values ​​of transformational leadership are considered very important in supporting employee performance. Transformational leadership includes two essential elements, namely relational and dealing with real change so that leaders and followers raise themselves to each other to arrive at certain levels of motivation and performance.
The brake pressure depends upon the pedal ratio
Authors: Lotte Julia Sophie , Luuk Daan Sem , Max Sven Noah , Nick Alexander Simon
Published: December 2019

The brake disc having a factor of safety (FOS) within the range of 2 to 3 is sustainable. The disc with a FOS less than 2 or greater than 3 undergoes distortion and are less sustainable. Theoretically it has been proven using graphs and calculations that a slight variation in the pedal ratio leads to a large variation in the clamping forces and stopping distance. As per the comparisons made from the FOS and as per result from Ansys, when the pedal force is 1200N and the pedal ratios are 7.2and 4.5, the FOS are 2.1 and 2.8 respectively. Hence the disc is sustainable. When the pedal force is 1500N, and the pedal ratio is 4.5, the FOS is 2.2. Hence in this case too, the disc is sustainable. Therefore by maintaining proper pedal ratios, the length of the pedal can be made compact and with effective braking effects. This phenomenon is useful in case of racing vehicles as it reduces the effort of driver. The proper pedal design work also determines the size of master cylinder to be adopted for the vehicle.
Talent acquisition and talent engagement practices significant impact over employee satisfaction
Authors: Marrybeth Jackqueen Keith , Brackz John Stave , Hadson William Boy , Zlong Marcus Sandy
Published: December 2019

It is observed that talent acquisition and talent engagement practices have a significant impact on employee satisfaction in the deemed universities. It is also disclosed that talent development and talent retention practices are found to be insignificant. It clearly indicates that the deemed universities are keen on talent acquisition and talent engagement, but they are failed in implementing talent development as well as talent retention strategies. Further, this analysis unveiled that talent acquisition and talent development practices have a significant impact on employee satisfaction in business schools. It is also disclosed that the talent engagement and talent retention practices are found to be insignificant. It clearly indicates that business schools are keen on talent acquisition and talent development, but they are failed in implementing talent engagement as well as talent retention strategies.
FRONT MATTER (Cover, Editorial Board, Foreward of Chairperson, Table of Contents)
Authors: - -
Published: December 2019

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PERILAKU SUPPORTER SEPAKBOLA PSIM YOGYAKARTA
Authors: Fradiantika Vita , Sukadiyanto Sukadiyanto
Published: December 2019

Penelitian ini bertujuan untuk mengetahui perilaku supporter sepakbola PSIM Yogyakarta. Penelitian ini menggunakan metode kualitatif dengan pendekatan studi kasus. Informan dalam penelitian ini menggunakan tiga orang pengurus Brajamusti, tiga orang pengurus The Maident, dan untuk tria-ngulasi menggunakan subjek Presiden Brajamusti, Ketua Umum The Maident, dan dua anggota kepo-lisian. Teknik pengumpulan data dalam penelitian ini menggunakan wawancara mendalam dengan pedoman wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa kedua kelompok supporter Brajamusti dan The Maident berperilaku fanatik dalam memberikan dukungan terhadap PSIM, sehingga sering menimbulkan perkelahian antarsupporter. Faktor yang menjadi penyebab pecahnya Brajamusti adalah faktor politik yang dilakukan oleh pihak tertentu untuk kepentingan politiknya. Dampak positif yang dihasilkan oleh kedua kelompok supporter berupa dukungan finansial hasil pembelian tiket setiap menonton pertandingan PSIM. Sedangkan dampak negatifnya adalah adanya persaingan yang tidak sehat antara Brajamusti dan The Maident sehingga dukungan kepada PSIM menjadi tersamarkan.  PSIM’s SUPPORTER BEHAVIOURAbstract This study aims to investigate the behavior of PSIM’s (Perserikatan Sepakbola Indonesia Mataram) supporters. This study used qualitative methods with case study approach. Informants used in this study consist of three members of Brajamusti board and three members of the Maident board. For the triangulation, in this study the Brajamusti President, Chairman of The Maident, and two police officers were interviewed. The results showed that Brajamusti and The Maident are behave fanatic in providing support to PSIM, so that often cause fights between supporters. Factor that cause the broken of Brajamusti is political that made by certain parties for political interests. The positive impact of these two groups of supporters are their contribution for buying tickets in every time they watch PSIM, so it can be a financial support. While the negative impact of the two groups of supporters are the unfair competition between them  that makes support for PSIM become obscured. Keywords: behavior, football, supporters
PENGEMBANGAN MULTIMEDIA PENDIDIKAN JASMANI MATERI BUDAYA HIDUP SEHAT UNTUK SEKOLAH MENENGAH ATAS
Authors: Fitriadi Arief , Rachman Hari Amirullah
Published: December 2019

Penelitian ini bertujuan untuk menghasilkan sebuah produk berupa multimedia pembelajaran pendidikan jasmani materi budaya hidup sehat dalam bentuk buku dan CD (Compact Disk). Jenis penelitian adalah Research and Development (R and D) dengan pendekatan survei melalui tes pengukuran. Penelitian pengembangan ini melalui empat tahapan, yaitu pendahuluan, tahap pengembangan, tahap uji lapangan dan tahap desiminasi produk. Populasi penelitian adalah siswa kelas X dan kelas XI SMA Negeri se-Kabupaten Yogyakarta sebanyak 83 orang. Instrumen pengumpulan data adalah lembar validasi untuk ahli materi dan ahli media, serta lembar kuesioner untuk siswa SMA. Hasil penelitian menunjukkan sebagai berikut: (1) Hasil validasi oleh ahli materi menilai ”Sangat Mudah”. Dari ahli media menilai ”Sangat Mudah”. Rata-rata hasil uji lapangan kelas X menunjukkan bahwa aspek pengoperasian CD ”Baik”, aspek pembelajaran CD ”Baik”, aspek pembelajaran buku ”Baik”, dan aspek kemenarikan CD ”Sangat Mudah”. Untuk kelas XI aspek pengoperasian CD ”Sangat Baik”, aspek pembelajaran CD ”Baik”, aspek pembelajaran buku ”Baik”, dan aspek kemenarikan CD ”Baik”. Kata Kunci: Multimedia, budaya hidup sehat.
PENGEMBANGAN MODEL LATIHAN KRIBO UNTUK POWER TUNGKAI ATLET LOMPAT JAUH DAN SPRINTER SKO SMP
Authors: Ismadraga Afristian , Lumintuarso Ria
Published: December 2019

Penelitian ini bertujuan untuk menghasilkan model latihan “KRIBO” (kreatif dan inovatif dengan bola) untuk melatih power tungkai atlet atletik nomor lompat jauh dan sprinter tingkat SMP. Model latihan “KRIBO” yang dikembangkan diharapkan dapat digunakan oleh pelatih atletik sebagai salah satu bentuk model latihan yang baik dan efektif. Penelitian pengembangan ini dilakukan dengan mengadaptasi langkah-langkah penelitian sebagai berikut: (1) penelitian dan pengumpulan data (2) perencanaan (3) pengembangan draft produkawal (4) ujicoba lapangan awal (5) revisi hasil ujicoba (6) ujicoba lapangan utama (7) revisi terhadap produk (8) melakukan ujicoba lapangan operasional (9) revisi produk akhir (10) desiminasi dan implementasi. Uji coba skala kecil dilakukan terhadap siswa kelas Olahraga kelas IX SMP N 1 Ngawen yang berjumlah 10 anak. Uji coba skala besar dilakukan terhadap siswa kelas Olahraga kelas IX SMP N 1 Ngawen dan SMP N 1 Playen, yang berjumlah 20 anak. Instrumen pengumpulan data yang digunakan yaitu: (1) pedoman wawancara, (2) skala nilai, (3) pedoman observasi model, (4) pedoman observasi keefektifan model, dan (5) kuesioner untuk siswa. Teknik analisis data yang dilakukan yaitu analisis deskriptif kuantitatif dan analisis deskriptif kualitatif. Dari hasil analisis data penilaian para ahli materi dan pelatih kelas olahraga cabang atletik, ditarik kesimpulan bahwa pengembangan model latihan ini sangat baik dan efektif.  DEVELOPING “KRIBO” MODEL FOR ATLETHIC POWER LEG TRAINING OF LONG JUMP AND SPRINTER FOR JUNIOR HIGH SCHOOL SPORT CLASS Abstract This reseach aims to produce “KRIBO” ( kreatif dan inovatif dengan bola) training model to train atletic of long jump and sprinter for junior high school sport class. The development of this model is expected to become a satisfactory and effective training model. This research and development was conducted by adapting the research as follows: (1) Research and information collection. (2) Planning (3) Develop preliminary form of product (4) Preliminary field testing (5) Main product revision (6) Main filed testing (7) Operasional product revision (8) Operational field testing  (9) Final product revision (10) Dissemination and implementation. The small-scale field trial was done by 10 students of grade IX class in SMP N 1 Ngawen. The large-scale field trials were done by 20 students of grade IX in SMP N 1 Ngawen and SMP N 1 Playen. The data collecting instruments were: (1) interview guide, (2) a value scale, (3) observation guide of the model, (4) an observasion guide of the model’s efectiveness, (5) a guestionnaire for the students. The data analysis method was a guantitative descriptive analysis and qualitative descriptive analysis. Based on the data analysis derived from coach and expert assessment, it is concluded that the model is training as very satisfactory and effective. Keywords: exercise models,”KRIBO”, long jump, sprinter
MODEL TES FISIK PENCARIAN BAKAT OLAHRAGA BULUTANGKIS USIA DI BAWAH 11 TAHUN DI DIY
Authors: Zhannisa Utvi Hinda , Sugiyanto FX.
Published: December 2019

Penelitian ini bertujuan untuk mengembangkan model tes fisik pencarian bakat cabang olahraga bulutangkis usia di bawah 11 tahun. Jenis penelitian ini adalah penelitian R and D (Research and Development). Dalam penelitian pengembangan ini, langkah-langkah yang harus ditempuh meliputi: (1) studi pendahuluan (studi pustaka dan studi lapangan), (2) perencanaan (melakukan analisis), (3) desain draft awal, (4) validasi draft (5) ujcoba produk kelompok kecil dan revisi, (6) uji coba kelompok besar dan revisi, (7) hasil akhir. Validitas menggunakan validitas isi, reliabilitas menggunakan test retest Conbrach’s Alpha dan Z skor untuk menyamakan satuan. Uji reliabilitas diperoleh hasil (a) tes kelentukan (sit and reach) 0,743; (b) tes kecepatan (lari 30 m) 0,844; (c) tes power otot tungkai (vertical jump) 0,663; (d) tes kelincahan (lari 4 sudut) 0,848; (e) tes power otot lengan (lempar bola) 0,943; (f) tes reaksi (step test) 0,987; (g) tes daya tahan (lari 600 m) 0,861. Produk yang dihasilkan berupa sebuah model tes dan norma tes untuk pencarian bakat.   A MODEL OF PHYSICAL TEST FOR TALENT SCOUTING IN BADMINTON SKILL UNDER 11 YEARS OLD IN DIY   Abstract The purpose of the research it to develop a model of physical test in looking for a sport talent in badminton skill under 11 years old. The type of this research is R and D (Research and Development) in this development research, the steps are (1) introduction study (bibiliography study, and field study), (2) planning (doing analysis), (3)introduction draft design, (4) validation draft, (5) trying out product in small group and revision, (6) trying out product in big group and revision, (7) final result. Validation used content validation, reliability used test retest and Z score to the same the unit.  The model of the test that has been arranged is suitable to be to look for talent in badminton skill. Reability test shows that: (a) sit and reach 0.743; (b) sprint 30 m 0.844; (c) vertical jump 0.663; (d) run 4 corner 0.848; (e) throw ball 0.943; (f) steps test 0.987;  and (g) endurance 0.861. Validity test shows that: (a) sit and reach 0.601; (b) sprint 30 m 0.731; (c) vertical jump 0.496; (d) run 4 corner 0.741; (e) throw ball  0.894; (f) steps test 0.975; and (g) endurance 0.756. Key words: development, model of test, looking talent, badminton