bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis, and in vitro Evaluation of Derivatives of Quinoxaline-2-
One as a Myeloperoxidase Modulator Using in silico Methods
Authors: Parameswaran Dakshinesh , Thangavelu Saravanan , Selvaraj Jubie , Chellappa Selvinthanuja , Vivekanandan Lalitha , Veerasamy Ravichandran , Thangavelu Prabha
Published: December 2023

Background:

In some pathological situations, the overproduction of oxidising agents
also results in oxidative damage to host cell proteins and DNA, which induces abnormal expression
of inflammatory cytokines and chemokines. A recently discovered biomarker of inflammation
is myeloperoxidase. Various inflammatory conditions cause the release of this enzyme into
the extracellular environment.

Objective:

Our study aimed to design, synthesize, and in vitro evaluate derivatives of quinoxaline-
2-one as a myeloperoxidase modulator using in silico methods.

Methods:

A series of quinoxaline-2-one derivatives was synthesized and characterized by
various analytical techniques. Further, to confirm and explore the molecular mechanism,
an in silico docking study against the myeloperoxidase enzyme was performed (PDB ID:
1DNU).

Results:

The compounds Q1, Q2, and Q5 showed better antioxidant activity in the DPPH assay,
whereas the nitric oxide scavenging assay showed the compounds Q2, Q4, and Q5 had significant
activity when compared to the standard IC50 value (28.8 μg/ml). Besides, the anti-inflammatory
studies showed the compounds Q1, Q3, and Q5 had better inhibition (89.79%) when compared to
the standard drug aceclofenac (85.37%) at 1000 μg/ml concentration. The top three ligands for
myeloperoxidase (PDB ID: 1DNU) with the highest scores in activity were found as Q2, Q1, and
Q5, with scores of -13.2838, -12.5841, and -11.6906 Kcal/mol, respectively. The compounds
were efficiently bound to the myeloperoxidase active site with arene-arene, arene-cation, and
hydrogen bonding interactions.

Conclusion:

By introducing the various heterocyclic rings and deactivating and activating
groups, we may produce a newer class of candidates for many infectious diseases. Thus, from the
computational studies carried out, we may obtain hints for optimising the molecular selectivity of
the quinoxaline-2-one derivatives to provide help in the design of new compounds for effective
myeloperoxidase enzyme modulators. However, further pharmacokinetics, pharmacodynamics,
preclinical, and clinical studies permit the design of the new agents without undesirable interactions.
Compression Promotes the Osteogenic Differentiation of Human
Periodontal Ligament Stem Cells by Regulating METTL14-mediated
IGF1
Authors: Wu Zengbo
Published: December 2023

Background and Objectives::

Orthodontic treatment involves the application of mechanical
force to induce periodontal tissue remodeling and ultimately promote tooth movement. It is essential
to study the response mechanisms of human periodontal ligament stem cells (hPDLSCs) to
improve orthodontic treatment.

Methods::

In this study, hPDLSCs treated with compressive force were used to simulate orthodontic
treatment. Cell viability and cell death were assessed using the CCK-8 assay and TUNEL staining.
Alkaline phosphatase (ALP) and alizarin red staining were performed to evaluate osteogenic
differentiation. The binding relationship between IGF1 and METTL14 was assessed using RIP
and dual-luciferase reporter assays.

Results::

The compressive force treatment promoted the viability and osteogenic differentiation of
hPDLSCs. Additionally, m6A and METTL14 levels in hPDLSCs increased after compressive
force treatment, whereas METTL14 knockdown decreased cell viability and inhibited the osteogenic
differentiation of hPDLSCs treated with compressive force. Furthermore, the upregulation
of METTL14 increased m6A levels, mRNA stability, and IGF1 expression. RIP and dual-luciferase
reporter assays confirmed the interaction between METTL14 and IGF1. Furthermore, rescue
experiments demonstrated that IGF1 overexpression reversed the effects of METTL14 knockdown
in hPDLSCs treated with compressive force.

Conclusions::

In conclusion, this study demonstrated that compressive force promotes cell viability
and osteogenic differentiation of hPDLSCs by regulating IGF1 levels mediated by METTL14.
Novel Anti-tumor Strategy for Breast Cancer: Synergistic Role of Oleuropein with
Paclitaxel Therapeutic in MCF-7 Cells
Authors: Yılmaz Gamze , Özdemir Filiz
Published: December 2023

Background:

The side effects of conventional therapeutics pose a problem for cancer treatment. Recently, combination treatments with natural compounds have attracted attention regarding limiting the side effects
of treatment. Oleuropein is a natural polyphenol in olives that has antioxidant and anticancer effects

Objective:

This study aimed to investigate the oxidative stress effect of a combination of Paclitaxel, a chemotherapeutic agent, and Oleuropein in the MCF-7 cell line.

Method:

The xCELLigence RTCA method was used to determine the cytotoxic effects of Oleuropein and
Paclitaxel in the MCF-7 cell line. The Total Oxidant and Total Antioxidant Status were analyzed using a kit. The
Oxidative Stress Index was calculated by measuring Total Oxidant and Total Antioxidant states. The levels of
superoxide dismutase, reduced glutathione and malondialdehyde, which are oxidative stress markers, were also
measured by ELISA assay kit.

Results:

As a result of the measurement, IC50 doses of Oleuropein and Paclitaxel were determined as 230 µM and
7.5 µM, respectively. Different percentages of combination ratios were generated from the obtained IC50 values.
The effect of oxidative stress was investigated at the combination rates of 10%, 20%, 30%, and 40% which were
determined to be synergistic. In terms of the combined use of Oleuropein and Paclitaxel on oxidative stress, antioxidant defense increased, and Oxidative Stress Index levels decreased.

Conclusion:

These findings demonstrate that the doses administered to the Oleuropein+Paclitaxel combination
group were lower than those administered to groups using one agent alone (e.g. Paclitaxel), the results of which
reduce the possibility of administering toxic doses.
Protective Effect of Hydroalcoholic Extract of Punica granatum Leaves on
High Fructose Induced Insulin Resistance in Experimental Animals
Authors: Bandawane Deepti , Kotkar Ashwini , Ingole Pooja
Published: December 2023

Background::

Insulin resistance (IR) is a condition characterized by reduced sensitivity
of body tissues to insulin, leading to impaired regulation of downstream metabolic pathways
and elevated blood glucose levels. Diets rich in fructose have been proven to cause insulin resistance
in test rats, resulting in decreased insulin sensitivity, particularly in the liver, and compromised
disposal of glucose from the body. In the search for effective treatments, Plant-derived
formulations have gained popularity because to their ability for treating a variety of ailments.
One such plant is Punica granatum Linn. from the Punicaceae family, which has long been used
in the treatment of diabetes and its consequences. This study investigates the insulin-resistant
activity of an extract from Punica granatum leaves. The study goal is to assess the possible protective
role of Punica granatum against insulin resistance through various analyses, including
serum glucose and insulin levels, lipid profile assessment, measurement of liver enzymes (ALP,
SGOT, SGPT), and histopathological examination of liver sections.

Methods::

The study involves several key methods to evaluate the insulin-resistant activity of
Punica granatum extract in high fructose diet induced insulin resistance animal model. The extract
was administered orally to the experimental animals. These methods include the measurement
of serum glucose and serum insulin levels, analysis of the lipid profile, quantification of
liver enzymes such as ALP, SGOT, and SGPT, and a detailed histopathological examination of
liver tissue sections. These analyses collectively provide insights into the impact of Punica
granatum extract on insulin resistance and related metabolic parameters.

Results::

Findings of this study provide insight on the possible benefits of Punica granatum extract
on insulin resistance. Through the assessment of serum glucose and insulin levels, lipid profile
analysis, and measurement of liver enzymes, the study elucidates the impact of the extract on
key metabolic indicators. Additionally, the histopathological examination of liver sections provides
visual insights into the structural changes that may occur as a result of the treatment.

Conclusion::

In conclusion, this study highlights the ability of Punica granatum extract as a candidate
for addressing insulin resistance. The findings suggest that the extract may have a protective
role against insulin resistance, as evidenced by improvements in serum glucose and insulin
levels, lipid profile, liver enzyme levels, and histopathological characteristics. Further research
and investigations are warranted to fully understand the mechanisms underlying these observed
effects and to validate the potential of Punica granatum extract as a therapeutic option for managing
insulin resistance and its associated complications.
Recent Developments in Drug Targets and Combination Therapy for the
Clinical Management of Hypertension
Authors: Niranjan Pradeep Kumar , Bahadur Shiv
Published: December 2023

Raised blood pressure is the most common complication worldwide that may lead to
atherosclerosis and ischemic heart disease. Unhealthy lifestyles, smoking, alcohol consumption,
junk food, and genetic disorders are some of the causes of hypertension. To treat this condition,
numerous antihypertensive medications are available, either alone or in combination, that work
via various mechanisms of action. Combinational therapy provides a certain advantage over
monotherapy in the sense that it acts in multi mechanism mode and minimal drug amount is required
to elicit the desired therapeutic effect. Such therapy is given to patients with systolic
blood pressure greater than 20 mmHg and/or diastolic blood pressure exceeding 10 mmHg beyond
the normal range, as well as those suffering from severe cardiovascular disease. The selection
of antihypertensive medications, such as calcium channel blockers, angiotensin-converting
enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and low-dose diuretics, hinges
on their ability to manage blood pressure effectively and reduce cardiovascular disease risks.
This review provides insights into the diverse monotherapy and combination therapy approaches
used for elevated blood pressure management. In addition, it offers an analysis of combination
therapy versus monotherapy and discusses the current status of these therapies, from researchbased
findings to clinical trials.
Insights Into the Role of Copper in Neurodegenerative Diseases and the Therapeutic Potential of Natural Compounds
Authors: Zhong Guangcheng , Wang Xinyue , Li Jiaqi , Xie Zhouyuan , Wu Qiqing , Chen Jiaxin , Wang Yiyun , Chen Ziying , Cao Xinyue , Li Tianyao , Liu Jinman , Wang Qi
Published: December 2023

Neurodegenerative diseases encompass a collection of neurological disorders originating from the progressive degeneration of neurons, resulting in the dysfunction of neurons. Unfortunately, effective therapeutic interventions for these diseases are presently lacking. Copper (Cu), a crucial trace element within the human body, assumes a pivotal role in various biological metabolic processes, including energy metabolism, antioxidant defense, and neurotransmission. These processes are vital for the sustenance, growth, and development of organisms. Mounting evidence suggests that disrupted copper homeostasis contributes to numerous age-related neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS), Wilson's disease (WD), Menkes disease (MD), prion diseases, and multiple sclerosis (MS). This comprehensive review investigates the connection between the imbalance of copper homeostasis and neurodegenerative diseases, summarizing pertinent drugs and therapies that ameliorate neuropathological changes, motor deficits, and cognitive impairments in these conditions through the modulation of copper metabolism. These interventions include Metal-Protein Attenuating Compounds (MPACs), copper chelators, copper supplements, and zinc salts. Moreover, this review highlights the potential of active compounds derived from natural plant medicines to enhance neurodegenerative disease outcomes by regulating copper homeostasis. Among these compounds, polyphenols are particularly abundant. Consequently, this review holds significant implications for the future development of innovative drugs targeting the treatment of neurodegenerative diseases.
Retraction note to: Analytical Method Development and Validation
for Determination of Assay of Antibacterial Drugs Besifloxacin Hydrochloride
and Phenoxyethanol in Gel Formulation
Authors: Kundu Pradeep , Pawar Neelam , Minocha Neha , Poonia Asha
Published: December 2023

The article entitled “Analytical Method Development and Validation for Determination of Assay of Antibacterial
Drugs Besifloxacin Hydrochloride and Phenoxyethanol in Gel Formulation”, by Pradeep Kundu, Neelam Pawar,
Neha Minocha and Asha Poonia, published in Anti-Infective Agents 2023; 21(4): e310323215342.
https://dx.doi.org/10.2174/2211352521666230331111623.

The corresponding author of this article submitted it simultaneously to the journal “Biochemistry & Analytical
Biochemistry of Walsh Medical Media publishers and to the journal of “Anti-Infective Agents” of Bentham
Science Publishers. Therefore, the article has been retracted due to the unethical practice of the author and during
plagiarism checking with a previously published article titled: “Analytical Method Development and Validation for
the Determination of Assay of Antibacterial Drugs Besifloxacin Hydrochloride and Phenoxyethanol in Gel
Formulation. Biochem Anal Biochem. 11:426. doi: 10.35248/2161-1009.22.11.426

The authors were informed of this submission and were suggested to give justification on the matter in their
defense. Instead of sending justification, the corresponding author Dr. Neelam Pawar suggested Bentham Science
Publishers to retract this article.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Editorial Policy of Bentham Science Publishers on Article Retraction can be found at the link
https://benthamscience.com/editorial-policies-main.php.

BENTHAM SCIENCE DISCLAIMER:

It is a condition of publication that manuscripts submitted to this journal have not been published and will not be
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A tánc és a sport közötti kapcsolat – különbségek, összefüggések, egymásra hatások
Authors: Lezó Nóra
Published: December 2023

A kérdés, miszerint a tánc sportnak számít-e, régóta foglalkoztatja a szakmát. Egyértelmű állásfoglalás ebben a kérdésben talán nem is lehetséges és nem is szükséges, inkább az összefüggések és az egymásra hatás vizsgálata a lényeges. A legfőbb különbség a két mozgásforma között, hogy a tánc egy művészeti ágazat, míg a sport egy fizikai teljesítmény. A hasonlóság pedig éppen a fizikai teljesítményben van, hiszen a tánc egy mozgásforma. A másik különbség maga a cél: a sportban a fizikai teljesítmény fokozása és a versenyzés, a táncban a színpadi előadások bemutatása. Ugyanakkor a táncművészetben is vannak határterületek; a rúdtánc, ami a sport és a tánc különös elegye, és a versenytánc (latin-amerikai, standard táncok) egyaránt sportnak számítanak, ahol alapvetően a versenyzés a cél, és ez határozza meg az edzésterveket is. Az utóbbi években a tánc, mint mozgásforma, újfajta kiegészítő edzésekkel, tréningekkel bővült mind hivatásos, mind hobbiszinten. Ezek az edzések az izommunkára, az egyensúlyra (balance-ra), az erőnlétre és az állóképességre összpontosítanak, tehát itt látható az első hasonlóság: a fizikai teljesítmény fokozása. Az egymásra hatás kölcsönös, hiszen a különböző sportágakban is megjelennek a táncos mozgásformák: a szinkronúszásban és a műkorcsolyázásban. Ebben az esetben a művészi többlet hozzáadása a cél, hiszen ezek a sportágak nem csupán a fizikai teljesítményről, hanem a művészi kifejezésmódról is szólnak. A kiegészítő mozgásformáknak a Covid miatti korlátozások idején különösen nagy jelentősége volt, jelenléti edzések hiányában otthoni, online edzések voltak, így ez a helyzet is indokolttá tette azoknak a kiegészítő mozgásformáknak a beépítését az edzéstervbe, amelyek segítségével az erőnlét és az állóképesség fenntartható és otthon is kivitelezhető.
Treće stoljeće edukativnih aktivnosti
Authors: Krznarić Željko , Cobal Sara , Matišić Ivona
Published: December 2023

Hrvatski liječnički zbor (HLZ) osnovan je 26. veljače 1874. radi unaprjeđenja zaštite zdravlja naroda, stručnog i znanstvenog rada, njegovanja liječničke etike i zaštite staleških interesa. Liečnički viestnik je najstariji hrvatski medicinski časopis s dugogodišnjom tradicijom. Prvi broj izašao je u siječnju 1877. Hrvatski liječnički zbor je osnivač Medicinskog fakulteta Sveučilišta u Zagrebu, Hrvatske liječničke komore te drugih udruga i institucija u Hrvatskoj. Hrvatski liječnički zbor ima 10 826 dobrovoljnih članova u 26 podružnica i 163 strukovna društva. Također, surađuje s najrelevantnijim javnim institucijama vezanim uz zdravstveni sustav Hrvatske. Jedan od glavnih projekata Hrvatskog liječničkog zbora jest izrada kliničkih smjernica za zdravstveni sustav Republike Hrvatske. Od 2004. više od 70 dijagnostičkih i terapijskih smjernica napisala su stručna društva Hrvatskog liječničkog zbora. Tijekom posljednjih pet godina Hrvatski liječnički zbor je također razvio i proveo projekte financirane od Europske unije, a usmjerene na internacionalizaciju visokog obrazovanja u Hrvatskoj (EXPPAND) i na prevenciju pretilosti djece u hrvatskim osnovnim školama (PETICA – igrom do zdravlja). Stručna društva Hrvatskog liječničkog zbora posvećena su cjeloživotnom učenju koje se sastoji od više od 2500 edukativnih aktivnosti godišnje. Zaključno, Hrvatski liječnički zbor već treće stoljeće kontinuirano utire put kao zalog za bolju budućnost hrvatskog zdravstvenog sustava ulažući u obrazovanje i usavršavanje liječnika koji su ključni za napredak medicine.
Unaprjeđenje nastavničkih kompetencija na Medicinskom fakultetu u Rijeci
Authors: Pereza Nina , Mršić-Pelčić Jasenka
Published: December 2023

Unaprjeđenje nastavničkih kompetencija u medicinskoj izobrazbi dio je šireg sustava profesionalnog razvoja djelatnika, poznatog i kao faculty development, odnosno usmjerene strategije visokoškolske ustanove u stjecanju znanja, vještina i stavova za usavršavanje u temeljnim djelatnostima institucije, uključujući nastavnički rad, metodologiju znanstveno-istraživačkog rada i rukovodećeg djelovanja. Organizirane strategije, uključujući provođenje edukacija i različitih profesionalnih aktivnosti, posebice su važne i razvijene u zdravstvenoj profesiji, a ostvaruju se osnivanjem zasebnih, istoimenih ustrojbenih jedinica, poput ureda, centara ili katedri. U modernoj medicinskoj izobrazbi od ključne je važnosti da svaka visokoškolska ustanova ima centraliziranu strategiju upravljanja profesionalnim razvojem nastavnika, koji treba biti usklađen s vizijom i misijom razvoja fakulteta, odnosno zasebnim resorima nastave i kontrole kvalitete. U ovom preglednom članku bit će opisano djelovanje Centra za unaprjeđenje nastavničkih kompetencija i komunikacijskih vještina Medicinskog fakulteta u Rijeci, kao osnovne ustrojstvene jedinice koja na organiziran i sustavan način skrbi o unaprjeđenju nastavničkih kompetencija na navedenoj instituciji od 2017. godine. Također, bit će prikazane edukacijske aktivnosti koje se u okviru Centra provode od navedene godine, uključujući program cjeloživotnog obrazovanja Stjecanje i unaprjeđivanje kompetencija za poučavanje u medicinskoj nastavi, tečajeve Osnove rada u sustavu za upravljanje učenjem na daljinu Merlin, Pripremni tečaj engleskog jezika za nastavnike, Engleski kao jezik visokoškolske nastave u medicini (EJVINMed) i Poučavanje u kliničkoj simulaciji. Poseban naglasak bit će stavljen na temeljni program za unaprjeđenje nastavničkih kompetencija na Medicinskom fakultetu u Rijeci, Moderna i praktična medicinska edukacija, koji se provodi od 2022. godine. Naposljetku, u članku će biti spomenute i ostale aktivnosti Centra, poput provođenja suradničke procjene i djelovanja Studentske sekcije.
Izazovi u primjeni europskih standarda u specijalističkom usavršavanju doktora medicine
Authors: Čikeš Nada
Published: December 2023

Poslijediplomsko specijalističko usavršavanje temelji se na Povelji o specijalističkom usavršavanju UEMS-a i dokumentu European Training Requirement, European Standards of Postgraduate Medical Specialist Training (ETR). Provedba ETR-a u nacionalnim sustavima donosi izazove u obrazovanju specijalizanta, odgovornosti mentora, ustanovi za provođenje specijalizacije te upravljanju kvalitetom. Glavni je izazov izobrazba s ciljem stjecanja kompetencija (competency based medical education, CBME), implementacija okvira kompetencija CanMEDS. Naglasak je na ocjenjivanju kompetencija na radnom mjestu, uključujući kliničke vještine te profesionalno ponašanje. Procjena napretka specijalizanta provodi se tzv. povjerenim profesionalnim aktivnostima (EPA) u specijalističkim programima. UEMS organizira europske specijalističke ispite.
Oblikovanje simulacijskih vježbi za studente medicine koji imaju malo iskustva u simulaciji
Authors: Šuper-Petrinjac Erika
Published: December 2023

Oblikovanje nove nastave izazovan je proces. Zbog promjena u obrazovanju liječnika u Republici Hrvatskoj ukinut je pripravnički staž i napravljene izmjene studijskog programa studija medicine. Katedra za anesteziologiju, reanimatologiju, hitnu i intenzivnu medicinu Medicinskog fakulteta Sveučilišta u Rijeci time je postala bogatija za kolegij Simulacija kliničkih vještina na šestoj godini studija. Budući da studenti prethodno nisu imali opsežno iskustvo u simulaciji, a istovremeno su imali veliku potrebu da kao liječnici (što će uskoro postati) znaju zbrinuti životno ugroženog bolesnika, razvoj kolegija predstavljao je velik izazov osoblju Katedre, unatoč prethodnom nastavničkom iskustvu. Kolegij je razvijen radom u timu, uzimajući u obzir lokalne posebnosti, manjak simulacijskog iskustva te je formirano pet velikih nastavnih cjelina, a svaka pojedina nastavna cjelina napravljena je kao dio slagalice koja na kraju omogućava uspješno liječenje bolesnika kroz sve korake, primjenjujući tehničke i netehničke vještine. Kolegij se redovito unaprjeđuje manjim izmjenama u svim sferama izvođenja nastave. Opisan je proces razvoja i unaprjeđenja nastave tijekom osam godina.
Vrijednost volontiranja – FOSS MEDRI
Authors: Brdar Lara
Published: December 2023

Volonterski rad za vrijeme studiranja može unaprijediti razne vještine studenata i pritom ih oblikovati u individue spremne za izazove koje donosi budući profesionalni svijet. Brojnim istraživanjima potvrđena je dobrobit volontiranja tijekom studiranja, ali i za buduće izazove. U ovom članku će, iz perspektive predsjednice Fakultetskog odbora svih studenata Medicinskog fakulteta u Rijeci, biti prikazani neki od aktivnih projekata ove neprofitne udruge, kao i opus iskustva i vještina koje studenti mogu steći kroz njih. Također, bit će prikazan pozitivan značaj volontiranja na psihofizički razvoj, zajedno s načinom na koji ono utječe na napredak društva, sklad zajednice i osobni rast.
Immune-Suppression Modulation in Solid Organ Transplant Recipients Admitted for COVID-19
Authors: Peracchi Francesco , Travi Giovanna , Merli Marco , Rossotti Roberto , Crippa Fulvio , Puoti Massimo
Published: December 2023

SARS-CoV-2 infection has significantly impacted solid organ transplant (SOT) recipients, who are at high risk of disease and worse outcomes. Moreover, therapeutic management in this population is not precise yet. Our study aimed to evaluate the overall survival of SOT recipients and predictive factors for mortality. We also aimed to assess the impact of antiviral treatments and immunosuppressant changes on overall mortality and to evaluate the length of hospital stay of SOT compared to the general population. This is a retrospective monocenter study. We included all SOT recipients with laboratory-confirmed SARS-CoV2 infection admitted at Niguarda Hospital in Milan from February 2020 through January 2022. We enrolled 74 solid organ transplant recipients with a median age of 59. The overall mortality rate was 19%. Older age, male sex, diabetes, and high LDH values were associated with an increasing fatality rate. The median length of stay (LoS) was 17 days. Low white blood count and lymphocyte levels were associated with 19 days LoS. Changes in immunosuppression and SARS-CoV-2 antiviral therapies had no impact on mortality and LoS. In this study, we confirm previously described risk factors for worse outcomes. We did not observe beneficial therapies in terms of mortality rate and LoS. Seven patients received antiviral treatment. More studies are needed to assess the best therapeutical options, including immunosuppressant modulation, in SOTs.
Stress Analysis and Life Prediction of a Ceramic Matrix Composite Vane Using a Micromechanics-Based Approach
Authors: Santhosh Unni , Ahmad Jalees
Published: December 2023

The results of stress analysis of a ceramic matrix composite (CMC) vane using a physics-based model developed for two-dimensional woven CMCs are presented. The model considers the inherent defects and micromechanical damage in woven CMCs along with time-dependent deformation of the constituents. Predictions include damage state under general load conditions and the global deformation response of the vane. Strain-gage data from burst tests are compared to strain predictions obtained using the model. Results from time-dependent analysis and life prediction of the vane under constant loads and cyclic loads at elevated temperatures are presented. Effect of fatigue frequency on the deformation and long-term life of the vane are also discussed.
Book «Recent Topics in Autonomic Nervous System» London, UK: IntechOpen, 2023. Edition by María Elena Hernández Aguilar and Gonzalo Emiliano Aranda Abreu
Authors: Authors No
Published: December 2023

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Characteristics of Nori Moringa Leaves with Suweg (Amorphophallus campanulatus) Starch Addition
Authors: Rahmawati Rahmawati , Mu’awwinatun Nur
Published: December 2023

Nori is a thin sheet made from dried Porphyra seaweed, which grows only in subtropical climates, posing challenges to its availability in Indonesia. To address this limitation, diversification of nori with other ingredients such as moringa leaves becomes imperative. Moringa leaves are used due to their green color, high nutritional content, and easy availability. A binder and gel-forming agent containing high amylopectin are also needed to achieve a high-quality and compact nori texture. Suweg is an underutilized gel-forming agent with high amylopectin content. Therefore, this research aimed to characterize moringa leaf nori supplemented with suweg starch (Amorphophallus campanulatus) at concentrations of 0%, 1.25%, 2.5%, 3.75%, and 5%. The results indicated that suweg starch influenced tensile strength, thickness, water content, water activity, ash content, and protein, as well as sensory tests for color, aroma, brittleness, and taste, while crude fiber content was not affected. Based on sensory, physical, and chemical tests the best nori was achieved with the addition of 1.25% suweg starch. The result of characterization of this nori included a tensile strength of 355.90 gf, thickness 0.0145 mm, water content 15.50%, water activity value 0.645, ash content 15.30%, protein content 9.88%, and crude fiber of 2.18%. The sensory evaluation showed that the nori had a green color (3.1), a subtle leafy aroma (3.1), slightly broken (2.9), and a slightly bitter taste (3.2) with preference scores categorized as preferred (3.5), slightly favored (3.3), favored (3.7), and moderately liked by the panelists (score 3.3), respectively. The resulting nori has a thinner thickness and lower tensile strength than commercial products
Effect of Priming on Brassica rapa subsp. chinensis (Bok Choy) Seeds Germination
Authors: Phooi Chooi Lin , Azman Elisa Azura , Ismail Roslan
Published: December 2023

Brassica rapa subsp. Chinensis, commonly known as Bok Choy, is a nutrient-rich vegetable with substantial antioxidant content. Therefore, this study aimed to evaluate the effect of hydropriming and bio-nutri-priming using Sandwich compost leachate on seed germination, SPAD reading, and dry matter accumulation in 280 dwarf variants of Bok Choy seeds sourced from Green Eagle. The experimental process involved hydropriming with tap water, bio-nutri-priming using 0.2% Sandwich compost leachate, and a control group cultivated in soil without priming. A complete randomization design (CRD) with three replications assessed seed germination performance, SPAD, root and shoot dry matter, and root-to-shoot ratio. While there was no significant difference in the germination percentage (88.35±1.13%), the entire priming seeds exhibited a 2-day peak germination period, compared to 3 days for the non-priming counterparts. Bio-nutri-priming seeds showed faster median and mean germination times due to enhanced nutrient uptake. They further displayed high SPAD readings, suggesting a lack of toxic compounds. The dry matter production of all treated Bok Choy was similar because administered treatments did not interfere with plant growth and development. Therefore, applying bio-nutri-priming using Sandwich compost leachate positively affected seed germination performance, warranting its recommendation as a seeds priming solution.
Characteristics of Bread with The Substitution of Fermented Purple Yam Flour (Dioscorea alata)
Authors: Ulyarti Ulyarti , Mursyid Mursyid , Lavlinesia Lavlinesia , Juliandri Iqbal Ridho , Nazarudin Nazarudin
Published: December 2023

Fermented purple yam flour is known to have high swelling power, which is capable of improving its ability as a substitute for wheat flour in bread production. Therefore, this study aimed to determine the effect of the substitution of wheat flour with fermented purple yam flour (FF), at 0%, 10%, 15%, 20%, 25%, and 30% concentrations on the physical, chemical, and sensory characteristics of bread. The result showed that FF concentration has no significant effect on the moisture content, specific loaf volume, hedonic aroma, and taste but significantly affected porosity, anthocyanin content, antioxidant activity, hedonic color, texture, and overall acceptance of the bread. Furthermore, the best treatment obtained was at the 25% substitution level, which produced bread with 29.30% moisture content, 27.18% porosity, 3.06 cm 3 /g specific loaf volume, and 5.30 mg/g anthocyanin. It also produced 61.03% antioxidant activity, color 3.88, texture 4.00, taste 3.92, and overall acceptance 4.00 (Likes). The maximum substitution rate of fermented purple yam flour was 25%.
Synthesis and Characterization of Nanomaterials from Porang (Amorphophallus muelleri) and Its Application for Bioplastic: Preliminary
Authors: Fadhallah Esa Ghanim , Indraningtyas Lathifa , Setiawan Teguh , Firdaus Iqbal , Pratama Andri
Published: December 2023

The increase in plastic waste caused by population growth and human activities is capable of leading to negative consequences for the environment. The substantial accumulation contributes to environmental pollution since its resilience against microbial degradation poses a significant challenge. Furthermore, the utilization of bioplastics as a biodegradable substitute presents a viable strategy for diminishing reliance on synthetic plastics. Starch emerges as a prevalent primary component in the fabrication of bioplastics, owing to its array of merits including renewability, cost-effectiveness, non-toxicity, and facile degradability. The application of nanomaterials to bioplastics is believed to accelerate the degradation of bioplastics.  Therefore, this study aimed to identify the characteristics of nanomaterial from porang (Amorphophallus muelleri) and bioplastic. The method included the extraction of porang nanomaterial through a specified water-to-porang ratio (2.5:1) followed by sonication (50 W, 75 minutes). The formulation of bioplastics involved the amalgamation of corn starch, porang nanomaterial, and glycerol. In addition, the chemical properties of porang nanomaterials included 41.41% starch content, 13.49% amylose, 7.87% ash, and 2.52% calcium oxalate. The particle size of porang nanomaterials was distributed from 603.7-952.1 nm with an average 722.6 nm crystalline structure containing calcium oxalate. The bioplastic had the form of a thin brown layer with a thickness value ranging from 0.23-0.39 mm. This research was expected to provide new information related to the essential characteristics of nanomaterials from porang and its potential application in solving environmental issues caused by synthetic plastics.
Characterization of Mixed Rice: Nutritional Value, Physicochemical Properties, Organoleptic, and Glycemic Index
Authors: Septianingrum Elis , Ardhiyanti Shinta Dewi , Liyanan Liyanan , Kusbiantoro Bram , Handoko Dody Dwi
Published: December 2023

The nutritional and physicochemical value of rice could be enhanced by mixing or combining white and brown rice with various beans. Besides nutritional and functional aspects, it is also crucial to consider organoleptic properties. Therefore, this study aimed to characterize nutritional value (proximate), physicochemical properties, organoleptic and Glycemic Index (GI) of mixed rice. A total of 10 mixed rice formulas, ranging from F1 to F10, and consisting of white rice, brown rice, black rice, aromatic rice, sticky rice, black-eyed peas and mung beans, were determined. These samples were analyzed for proximate, total phenolic compounds, pasting properties, and organoleptic tests (hedonic and ranking tests). Furthermore, 3 selected formulas based on the previous test were then evaluated for GI, and Glycemic Load (GL) was calculated. The results showed that adding black-eyed peas and mung beans (F9 and F10) increased the protein content of mixed rice while higher proportion of black or brown rice (F3 and F4) enhanced the fat content. The amylose content was decreased due to higher proportion of sticky rice (F6 and F8). Based on the hedonic test, the F1-F6 formula had a favorable rating. The ranking results indicated that F9 was better than F10, while F1 and F6 was the best among F1 to F4, as well as F5 to F8. Considering the constituent materials, F1, F6, F9 and commercial low GI rice were selected and tested for GI, and the test results showed 48.2, 54.7, 78.0, and 60.3, respectively. As a result, F1 and F6 have the potential to be developed as mixed rice because they have good nutritional value, physicochemical and organoleptic properties, as well as low GI.
Penerimaan remaja putri terhadap tablet tambah darah di Kota Yogyakarta
Authors: Masfufah Masfufah , Kandarina Istiti , Padmawati Retna Siwi
Published: December 2023

Acceptance of adolescent girls on iron tablets in Yogyakarta, IndonesiaBackground: Supplementation of iron tablets is one of the efforts to combat anemia in adolescent girls taken by the government. However, compliance with iron tablet consumption still tends to be low. Objective: This study aims to determine the acceptance of adolescent girls to iron tablets in Yogyakarta. Methods: This study is a sequential explanatory mixed method. The investigation was conducted from January to April 2018. The subjects of the study were girls in junior high and high school of Yogyakarta, as many as 211 people with criteria 12-18 years; FGD/in-depth interview respondents were 32 students, four teachers/UKS officer, two Puskesmas officers, and one health program holder. Results: Of 204 subjects who received iron tablets, only 133 subjects (65.20%) consumed iron tablets, and 71 subjects (34.80%) did not. The organoleptic perception of subjects consisting of flavor, aroma, and color indicates they like iron tablets, but some also do not want them because they smell fishy. Side effects of iron tablets, such as nausea, heartburn, constipation, and dizziness, are the reasons the subject does not consume or spend the iron tablets given. In addition to the encouragement or support of parents, teachers or officers of UKS, and health workers, it is a factor that affects the acceptance of subjects against iron tablets. Conclusion: Factors influencing the acceptance of adolescent girls to iron tablets are a factor in self and factors from outside (parents, teachers, and health workers). Therefore, increasing the consumption of iron tablets requires young women's self-awareness, motivation, and support from various parties to obtain information related to the iron tablet, such as socialization
Pendampingan gizi pada ibu hamil kurang energi kronik (KEK) dan anemia terhadap peningkatan asupan gizi
Authors: Simbolon Demsa , Rahmadi Antun , Jumiyati Jumiyati , Sutrio Sutrio
Published: December 2023

Nutrition assistance for pregnant women with chronic energy deficiency and anemia to increase nutritional intakeBackground: Nutrition assistance for pregnant women with chronic energy deficiency (CED) with family or community empowerment strategies and community participation is necessary to improve the nutritional status of pregnant women and babies during the 1000 first days of life.Objective: This study aims to determine the effect of assisting pregnant women with CED on changes in nutrition intake in Bengkulu and Bandar Lampung City.Methods: The research design used a quasi-experimental design with a non-randomized control group pre and post-test design. The research was conducted in Bengkulu and Bandar Lampung city. A sample of 120 pregnant women with CED and anemia, consisting of 60 intervention groups and 60 control groups selected by purposive sampling. The intervention group received assistance from pregnant women by health cadres using nutrition education media from the second trimester of pregnancy to the mother before delivery for 3 months. Cadres carry out health promotion, monitor the nutritional status of pregnant women, and assist in supplementary feeding of pregnant women and Fe tablets. The control group received standard services from the puskesmas/posyandu without assistance from cadres. Nutrition intake includes intake of carbohydrates, protein, fat, iron, and calcium. Changes in nutritional intake before and after training were analyzed using a statistical paired t-test. Differences in nutritional intake between the intervention and control groups using independent t-test.Results: Nutrition assistance for pregnant women with CED and anemia was effective in improving the intake of carbohydrates, protein, fat, Fe, and calcium. There was an increase in the average intake of carbohydrates, protein, fat, Fe, and calcium in Bengkulu and Bandar Lampung City.Conclusions: Nutrition assistance for pregnant women with CED and anemia is effective in increasing nutrition intake.
Korelasi indeks massa tubuh terhadap rasio trigliserida dan high-density lipoprotein-cholesterol pada wanita usia subur dengan obesitas
Authors: Nasruddin Nina Indriyani , Saimin Juminten , Tosepu Ramadhan
Published: December 2023

Body mass index correlation with triglyceride and high-density lipoprotein-cholesterol ratio of reproductive age women with obesityBackground: Obesity in women of reproductive age is thought to be one of the triggers of coronary heart disease. Body mass index (BMI) correlates well with the percentage of body fat, which is a strong indicator of coronary heart disease. Accumulation of visceral adipocytes releases excess free fatty acids, resulting in increased triglyceride synthesis. Furthermore, in a state of hypertriglyceridemia, there is a decrease in HDL levels and an increase in HDL catabolism resulting in decreased HDL levels. Examination of the ratio of triglyceride levels and high-density lipoprotein cholesterol (TG/HDL-C) is a strong indicator of cardiovascular disease.Objective: The aim of his study was to investigate the correlation between BMI and TG/HDL-C ratio in women of reproductive age.Methods: Using an analytical approach with a cross-sectional design. Furthermore, height and weight were measured with Smic ZT 120. At the same time as this examination, venous blood was taken from the median cubital area to be used to check the level of triglycerides and HDL-C in the serum. TG examination with GPO-PAP and HDL-C direct method. The bivariate analysis uses the Spearman Rank correlation test, while the multivariate analysis uses the linear regression test.Results: TG levels were 106 (34-363) mg/dl, HDL-C levels were 48.19 ± 9.91 mg/dl, and the ratio between the two was 2.26 (0.52-9.58). Spearman Rank analysis obtained the value of r was 0.573, p-value 0.0001.Conclusions:  There is a significant positive correlation between BMI and the ratio of TG/HDL-C levels in adult women of reproductive age with obesity.
Usia ibu dan jumlah anak berhubungan dengan kejadian beban gizi ganda pada tingkat rumah tangga di desa dan kota di Indonesia
Authors: Astuti Nur Fitri Widya , Huriyati Emy , Susetyowati Susetyowati
Published: December 2023

Maternal age and number of children are associated with the incidence of a double burden of malnutrition at the household level in rural and urban areas in IndonesiaBackground:  Double burden of malnutrition is a nutritional problem where two nutritional problems occur at the same time and this can happen at the household level. The diversity of community characteristics causes differences in the incidence of the double burden of malnutrition at the household level in people living in rural and urban areas in Indonesia.Objective: To determine the associated factors with the incidence of double burden malnutrition at the household level in rural and urban areas in Indonesia.Methods: This study with a cross-sectional design used secondary data from the fifth wave of the Indonesia Family Life Survey (IFLS). The sample in this study was 6,468 households. The double burden of malnutrition at the household level is defined as a household in which there is at least one pair of mother and child aged 2-18 years that has underweight and or overweight/obese. Maternal factors, household economic status, number of children, and regional area are independent variables in this study. A logistic regression test was used to perform statistical analysis.Results: The prevalence of double burden malnutrition at the household level in urban areas was higher than in rural areas (8.70%) and 7.77%). Factors that were significantly (p<0.05) associated with the incidence of double burden malnutrition at the household level in rural areas were maternal age, mother's education, economic level, number of children, and regional living of the household, while in urban areas were maternal age and number of children.Conclusions: Maternal age and the number of children are two significant factors associated with the incidence of double burden malnutrition at the household level in rural and urban areas in Indonesia.
Analysis of Talent Cultivation Methods for Digital Commerce Professional Groups
Authors: Bing Xue
Published: December 2023

With the advent of the digital economy era, business education is also facing new challenges and opportunities. The digital commerce professional group, as a new educational concept and carrier, provides new ideas for the integration and exchange of various business majors in vocational education. In this digital and intelligent era, commercial activities are no longer limited to the traditional real economy, but increasingly rely on digital technology and internet platforms. Therefore, cultivating talents with professional knowledge and skills in digital commerce has become an urgent task in business education. This article mainly analyzes the methods of cultivating talents in the digital commerce professional group.
СИНТЕЗ И СТАБИЛИЗАЦИЯ НАНОРАЗМЕРНОГО КАРБОНАТА КАЛЬЦИЯ МЕТИЛЦЕЛЛЮЛОЗОЙ
Authors: Блинов А.В. , Рехман З.А. , Гвозденко А.А. , Голик А.Б. , Шевченко И.М. , Ясная М.А. , Синюгина П.Г.
Published: December 2023

В работе представлен метод синтеза наночастиц карбоната кальция, стабилизированных метилцеллюлозой. В качестве прекурсора использовали ацетат кальция, а осадителем выступал карбонат аммония. Исследовали микроструктуру поверхности полученных образцов методом сканирующей электронной микроскопии и в результате установили, что образец представлен полыми сферами диаметром около 2 мкм, размер частиц в которых варьируется от 40 до 250 нм. Для определения оптимального типа взаимодействия частиц со стабилизатором проводили компьютерное квантово-химическое моделирование. Выявили, что процесс стабилизации наноразмерного карбоната кальция и метилцеллюлозы энергетически выгоден. Также для подтверждения результатов моделирования образцы исследовали методом ИК-спектроскопии с преобразованием Фурье. Анализ результатов выявил, что взаимодействие наночастиц CaCO3 происходит с заряженной группой OH–.
ФОРМИРОВАНИЕ КОМПОЗИЦИОННЫХ МЕМБРАН С АСИММЕТРИЕЙ ПРОВОДИМОСТИ МЕТОДОМ ПЛАЗМОХИМИЧЕСКОГО ОСАЖДЕНИЯ НАНОЧАСТИЦ ДИОКСИДА КРЕМНИЯ
Authors: Кравец Л.И. , Алтынов В.А. , Гайнутдинов Р.В, , Шестериков Е.В. , Кулинич И.В. , Твердохлебов С.И.
Published: December 2023

Проведено исследование поверхностных и электрохимических свойств трековой мембраны из полиэтилентерефталата, на одну из сторон которой методом плазмохимического осаждения из газовой фазы смеси силана и закиси азота наносили наноразмерные покрытия из диоксида кремния. Показано, что осаждение слоя диоксида кремния на поверхность мембраны приводит к созданию композиционных мембран, обладающих в растворах электролитов асимметрией проводимости.
ИССЛЕДОВАНИЕ ВЛИЯНИЯ ТИПА ПРЕКУРСОРА НА ДИСПЕРСНЫЕ ХАРАКТЕРИСТИКИ НАНОЧАСТИЦ СЕЛЕНА
Authors: Блинов А.В. , Шевченко И.М. , Гвозденко А.А. , Рехман З.А. , Голик А.Б. , Блинова А.А. , Вакуленко М.В.
Published: December 2023

В рамках данной работы исследовано влияние типа прекурсора и стабилизатора на дисперсионные характеристики наночастиц селена, в частности, средний гидродинамический радиус и ζ-потенциал частиц. Наночастицы получали методом химического восстановления в водной среде. В качестве прекурсора использовали селениты лития, натрия, калия, а в качестве восстановителя – аскорбиновую кислоту, в качестве стабилизатора – 4 поверхностно-активных вещества: анионактивное – лауретсульфат натрия, катионактивное – ЦТАХ, неионогенное – Твин-80, амфотерное – кокамидопропилбетаин. У образцов, стабилизированных лауретсульфатом натрия, наблюдается отрицательное значение данного показателя, при использовании остальных стабилизаторов – положительное значение ζ-потенциала. Оптимальным поверхностно-активным веществом является кокамидопропилбетаин, что обусловлено тем, что при изменении концентраций веществ, он показал наименьшие изменения среднего гидродинамического радиуса и ζ-потенциала наночастиц селена. Показано, что тип и концентрация прекурсора оказывают незначительное влияние на средний гидродинамический радиус наночастиц селена. Установлено, что увеличение концентрации прекурсора приводит к уменьшению по модулю ζ-потенциала частиц. Важно отметить, что тип прекурсора не оказывает значительного влияния на ζ-потенциал наночастиц селена.