bluuebunny/crossref_metadata_2025 huggingface dataset:
Ginsenoside Rb3 Alleviates the Toxic Effect of Cisplatin on the Kidney during Its Treatment to Oral Cancer via TGF-β-Mediated Mitochondrial Apoptosis
Authors: Wu Wen-Jie , Tang Yu-Fang , Dong Shuang , Zhang Jie
Published: January 2021

Objective. The research aimed to confirm the role of the transforming growth factor-β (TGF-β) in cisplatin- (CPT-) evoked kidney toxicity and elucidate the mechanism that ginsenoside Rb3 (Rb3) could alleviate the kidney toxicity by CPT during its treatment to oral cancer via TGF-β-mediated mitochondrial apoptosis. Methods. The model of xenograft nude mice bearing oral carcinoma cells ACC83 was established and treated with CPT and/or Rb3, respectively. Bodyweights of the treated mice were weighed, and the kidney tissues were collected; following, the histopathology and the expression of TGF-β were examined using H&E staining and immunohistochemistry. Afterward, the renal cells GP-293 were treated with CPT and/or Rb3. The expression and phosphoration of TGF-β, Smad2, Smad3, Bcl-2, and Bax in GP-293 cells were detected by Western blotting. The cellular apoptosis and mitochondrial membrane potential were analyzed using flow cytometry. Results. The xenograft nude mice exposure to CPT presented the bodyweight loss, necrotic areas, and the increased expression of TGF in kidney tissue, and Rb3 pretreatment relieved these changes evoked by CPT. In GP-293 cells, CPT administration induced the phosphorylation of Smad2 and Smad3, and Rb3 pretreatment suppressed the induced phosphorylation by CPT. Besides, flow cytometry analysis showed that Rb3 inhibited the CPT-evoked cellular apoptosis ratio and mitochondrial membrane depolarization. The Western blotting test indicated that Rb3 alleviated the cleavage of PARP, caspase 3, caspase 8, and caspase 9, the induction of Bax expression, and inhibition of Bcl-2 expression. Additionally, after treating with the TGF inhibitor of disitertide, Rb3 exhibited no alleviation effects on CPT-evoked cellular apoptosis ratio, inhibition of Bax expression, and induction of Bcl-2 expression in GP-293 cells. Conclusion. Rb3 could alleviate CPT-evoked toxic effects on kidney cells during its treatment to oral cancer via TGF-β-mediated mitochondrial apoptosis.
Effect of Detuning of Clamping Force of Tie Rods on Dynamic Performance of Rod-Fastened Jeffcott Rotor
Authors: Xu Haoliang , Yang Lihua , Xu Tengfei , Wu Yao
Published: January 2021

In view of the advantages of lightweight, high strength, easy cooling, and easy assembly, the rod-fastened rotor is widely used in the aeroengine and heavy gas turbine. However, because of assembly, stress relaxation, material creep, and other reasons, the clamping force of the tie rods will be out of tune during the long-term operation of the rotor. The detuning of the clamping force of the tie rods not only affects the contact stiffness of the contact interface but also causes the rod-fastened rotor with a certain residual shaft bow, which will affect the dynamic characteristics of the rod-fastened rotor. Based on the statistical model of rough surface contact (GW contact model), this paper presents a method to calculate the equivalent flexural stiffness of rough surface considering the detuning of the clamping force of the tie rods and gives the calculation method of the residual shaft bow deformation of the rod-fastened Jeffcott rotor with detuning of the tie rods. The effect of the preload, the rate of detuning of the tie rods, the number of detuning tie rods on the natural frequency, and the response of residual shaft bow of the rod-fastened Jeffcott rotor at a certain speed are investigated. The results show that the detuning of the tie rods makes the flexural stiffness of the rotor inconsistent along with two main stiffness directions of the rotor, which makes the natural frequency of the rotor divided into two. The negative detuning of the tie rods decreases the natural frequency of the rotor, while the positive detuning of the tie rods increases the natural frequency of the rotor. The smaller preload or the larger rate of detuning of the tie rods makes the detuning of the tie rods have a greater influence on the natural frequency of the rotor. These results will provide a theoretical reference for the dynamic analysis and design of the rod-fastened rotor.
Body Composition Analysis of 10 Years versus 5 Years of Adjuvant Endocrine Therapy in Patients with Nonmetastatic Breast Cancer
Authors: Hu Ruyi , Cheng Xinran , Liu Jun , Lai Xu , Wang Ruifeng , Yu Dongchang , Fan Yanan , Yu Zhaoshi
Published: January 2021

Objective. Our study aims to investigate the association of extended adjuvant endocrine therapy with disease-free survival (DFS), muscle mass, muscle strength, and visceral adipose tissue in patients with nonmetastatic breast cancer and the effect of extended endocrine therapy on body composition. Patients and Methods. Patients (N = 90) with nonmetastatic breast cancer aged between 60 and 65 years old were prospectively recruited in this study, compromising a cohort of subjects rece iving 5 years or 10 years of adjuvant endocrine therapy. Patients’ DFS was compared between these two groups. Patients’ body composition including muscle and fat using CT scans, muscle strength, and gait speed was evaluated in these two groups. Results. Dietary behavior was recorded with the food frequency questionnaire (FFQ). Patients’ age, body weight, and body mass index (BMI) did not differ between the two groups. An extended adjuvant endocrine therapy into 10 years could translate into DFS benefit (123.8 vs. 102.2 months,

P
=
0.038

). Patients receiving 10 years of adjuvant endocrine therapy had less skeletal muscle and more visceral fat compared with patients receiving 5 years of adjuvant endocrine therapy. The skeletal muscle index was 50.3 ± 1.6 cm2/m2 versus 46.5 ± 1.3 cm2/m2 in the 10 years or 5 years of adjuvant endocrine therapy group (

P
=
0.042

). The visceral fat was 28.9 ± 2.9 cm2/m2 versus 55.0 ± 3.2 cm2/m2 in the 10 years or 5 years of adjuvant endocrine therapy group (

P
=
0.011

). The muscle strength, gait speed, and FFQ results in the two groups not reaching statistical difference. Conclusion. In conclusion, breast cancer patients with 10 years of adjuvant endocrine therapy had DFS benefit, but with more muscle loss and adipose tissue deposits compared to patients receiving 5 years of adjuvant endocrine therapy.
BAF Complex in Embryonic Stem Cells and Early Embryonic Development
Authors: Zhang Heyao , Wang Xuepeng , Li Jingsheng , Shi Ronghua , Ye Ying
Published: January 2021

Embryonic stem cells (ESCs) can self-renew indefinitely and maintain their pluripotency status. The pluripotency gene regulatory network is critical in controlling these properties and particularly chromatin remodeling complexes. In this review, we summarize the research progresses of the functional and mechanistic studies of BAF complex in mouse ESCs and early embryonic development. A discussion of the mechanistic bases underlying the distinct phenotypes upon the deletion of different BAF subunits in ESCs and embryos will be highlighted.
Colonic Transendoscopic Enteral Tubing: Route for a Novel, Safe, and Convenient Delivery of Washed Microbiota Transplantation in Children
Authors: Zhong Min , Buch Heena , Wen Quan , Long Chuyan , Cui Bota , Zhang Faming
Published: January 2021

Aim. Colonic transendoscopic enteral tubing (TET) has been used for delivering fecal microbiota transplantation by washed preparation since 2015, which was recently named as washed microbiota transplantation (WMT). However, there are few reports available regarding the feasibility and safety of these studies in low-age population. This study is aimed at evaluating the safety, feasibility, and value of colonic TET in 3-7 years old children. Methods. All patients aged 3-7 years who underwent colonic TET in our center for WMT or medication were prospectively evaluated. The feasibility and safety of TET were evaluated. A questionnaire was completed by the children’s parents to evaluate the children’s response to the colonic TET as well as the parent’s satisfaction. Results. Forty-seven children were included (mean age 5 years). TET was implemented into the colon of all the patients, and the success rate of the procedure was 100%. The median retention time of TET tube within the colon was 6 (IQR 5-7) days in 45 patients with tube falling out spontaneously, and the maximum retention time was up to 21 days. Multivariate analysis demonstrated that endoscopic clip number (

P
=
0.009

) was an independent contributing factor for the retaining time of tube. With increase in the number of large clips, the retention time of TET tube was prolonged. No discomfort was reported during injection of the microbiota or medication suspension through the TET tube. During the follow-up, no severe adverse events were observed. All children’s parents were satisfied with TET. Interestingly, the proportion of children’s parents choosing TET as the delivery way of WMT increased from 29.79% before to 70.21% after TET (

P
<
0.001

). Conclusions. This study, for the first time, demonstrates that colonic TET is a novel, safe, and convenient colonic delivery way for WMT and medication in children aged 3-7 years.
Optimization of In Vivo Studies by Combining Planar Dynamic and Tomographic Imaging: Workflow Evaluation on a Superparamagnetic Nanoparticles System
Authors: Rouchota Maritina , Adamiano Alessio , Iafisco Michele , Fragogeorgi Eirini , Pilatis Irineos , Doumont Gilles , Boutry Sébastien , Catalucci Daniele , Zacharioudaki Argyro , Kagadis George C.
Published: January 2021

Molecular imaging holds great promise in the noninvasive monitoring of several diseases with nanoparticles (NPs) being considered an efficient imaging tool for cancer, central nervous system, and heart- or bone-related diseases and for disorders of the mononuclear phagocytic system (MPS). In the present study, we used an iron-based nanoformulation, already established as an MRI/SPECT probe, as well as to load different biomolecules, to investigate its potential for nuclear planar and tomographic imaging of several target tissues following its distribution via different administration routes. Iron-doped hydroxyapatite NPs (FeHA) were radiolabeled with the single photon γ-emitting imaging agent [99mTc]TcMDP. Administration of the radioactive NPs was performed via the following four delivery methods: (1) standard intravenous (iv) tail vein, (2) iv retro-orbital injection, (3) intratracheal (it) instillation, and (4) intrarectal installation (pr). Real-time, live, fast dynamic screening studies were performed on a dedicated bench top, mouse-sized, planar SPECT system from [Formula: see text] to 1 hour postinjection (p.i.), and consequently, tomographic SPECT/CT imaging was performed, for up to 24 hours p.i. The administration routes that have been studied provide a wide range of possible target tissues, for various diseases. Studies can be optimized following this workflow, as it is possible to quickly assess more parameters in a small number of animals (injection route, dosage, and fasting conditions). Thus, such an imaging protocol combines the strengths of both dynamic planar and tomographic imaging, and by using iron-based NPs of high biocompatibility along with the appropriate administration route, a potential diagnostic or therapeutic effect could be attained.
Antimicrobial Resistance in Enterobacterales Bacilli Isolated from Bloodstream Infection in Surgical Patients of Polish Hospitals
Authors: Kłos M. , Pomorska-Wesołowska M. , Romaniszyn D. , Wójkowska-Mach J. , Chmielarczyk A.
Published: January 2021

Background and Aims. Bloodstream infections (BSIs) are one of the most frequently observed hospital-acquired infections (HAIs). We sought to describe the epidemiology and drug resistance secondary Enterobacterales BSIs in surgical patients and check for any correlation with the type of hospital ward. Materials and Methods. This multicenter (13 hospitals in southern Poland) laboratory-based retrospective study evaluated adults diagnosed with BSI secondary to surgical site infection (SSI) hospitalized in 2015–2018; 121 Enterobacterales strains were collected. The drug resistance was tested according to the EUCAST recommendations. Tests confirming the presence of extended-spectrum β-lactamases (ESBLs) and bla resistance genes were carried out. The occurrence of possible clonal epidemics among K. pneumoniae strains was examined. Results. The prevalence of Enterobacterales in secondary BSI was 12.1%; the most common strains were E. coli (n = 74, 61.2%) and Klebsiella spp. (n = 33, 27.2%). High resistance involved ampicillin and ampicillin/sulbactam (92, 8–100%), fluoroquinolones (48–73%), and most cephalosporins (29–50%). Carbapenems were the antimicrobials with the susceptibility at 98%. The prevalence of ESBL strains was 37.2% (n = 45). All the ESBL strains had blaCTX-M gene, 26.7% had the blaSHV gene, and 24.4% had blaTEM gene. The diversity of Klebsiella strains was relatively high. Only 4 strains belonged to one clone. Conclusions. What is particularly worrying is the high prevalence of Enterobacterales in BSI, as well as the high resistance to antimicrobial agents often used in the empirical therapy. To improve the effectiveness of empirical treatment in surgical departments, we need to know the epidemiology of both surgical site infection and BSI, secondary to SSI. We were surprised to note high heterogeneity among K. pneumoniae strains, which was different from our previous experience.
Characteristics of a Multiple-Layered Graphene Oxide Memory Thin Film Transistor with Gold Nanoparticle Embedded as Charging Elements
Authors: Kim Yo-Han , Nguyen Huynh Quoc , Park Bum Jun , Lee Hyun Ho , Seo Tae Seok
Published: January 2021

In this study, we report the highest mobility in the reduced graphene oxide- (rGO-) based TFTs embedded with Au NPs. In addition, we fabricated a reduced graphene oxide memory device (rGO-capacitor), a reduced graphene oxide thin film transistor (rGO-TFT), and a reduced graphene oxide memory thin film transistor (rGO-MTFT) and characterized their electrical performances. While the rGO-TFT device was investigated for nonambipolar channel performance, the rGO-capacitor and rGO-MTFT were examined for nonvolatile memory capabilities in a metal-graphene-insulator-silicon (MGIS) structure. The incorporation of the gold nanoparticles (Au NPs) between the rGO and an insulator silicon dioxide (SiO2) layer served as a charging element. The rGO-capacitor revealed the memory effect of hysteretic capacitance-voltage (C-V) loops, and the flat-band voltage shift (

Δ

V

FB

) was measured as 0.1375 V after 100 s retention time. The rGO-TFT shows the p-channel characteristics with high hole mobility of 16.479 cm2/V⋅s. The threshold voltage shift (

Δ

V

th

) of the rGO-MTFT was detected as 5.74 V from 10 V to -30 V sweep, demonstrating high mobility of 22.887 cm2/V⋅s.
Dynamics and Robust Control of a New Realizable Chaotic Nonlinear Model
Authors: Higazy M. , Mahmoud Emad E. , Khalil E. M. , Abdel-Khalek S. , Abo-Dahab S. M. , Alotaibi Hammad
Published: January 2021

We present a new viable nonlinear chaotic paradigm. This paradigm has four nonlinear terms. The essential features of the new paradigm have been investigated. Our new system is confirmed to have chaotic behaviors by calculating its Lyapunov exponents. The relations of the system states are displayed by a suggested new signal flow graph (SFG). The proposed SFG is discussed via some graph theory tools, and some of its hidden features are calculated. In addition, the system is realized via constructing its electronic circuit which helps in the real applications. Also, a robust controller for the system is designed with the aid of a genetic algorithm.
Indoor Vision/INS Integrated Mobile Robot Navigation Using Multimodel-Based Multifrequency Kalman Filter
Authors: Xu Yuan , Liu Tongqian , Sun Bin , Zhang Yong , Khatibi Siamak , Sun Mingxu
Published: January 2021

In order to further improve positioning accuracy, this paper proposes an indoor vision/INS integrated mobile robot navigation method using multimodel-based multifrequency Kalman filter. Firstly, to overcome the insufficient accuracy of visual data when a robot turns, a novel multimodel integrated scheme has been investigated for the mobile robots with Mecanum wheels which can make fixed point angled turns. Secondly, a multifrequency Kalman filter has been used to fuse the position information from both the inertial navigation system and the visual navigation system, which overcomes the problem that the filtering period of the integrated navigation system is too long. The proposed multimodel multifrequency Kalman filter gives the root mean square error (RMSE) of 0.0184 m in the direction of east and 0.0977 m in north, respectively. The RMSE of visual navigation system is 0.8925 m in the direction of east and 0.9539 m in north, respectively. Experimental results show that the proposed method is effective.
Fecal Microbiota Transplantation: A New Therapeutic Attempt from the Gut to the Brain
Authors: Xu Hao-Ming , Huang Hong-Li , Zhou You-Lian , Zhao Hai-Lan , Xu Jing , Shou Di-Wen , Liu Yan-Di , Zhou Yong-Jian , Nie Yu-Qiang
Published: January 2021

Gut dysbacteriosis is closely related to various intestinal and extraintestinal diseases. Fecal microbiota transplantation (FMT) is a biological therapy that entails transferring the gut microbiota from healthy individuals to patients in order to reconstruct the intestinal microflora in the latter. It has been proved to be an effective treatment for recurrent Clostridium difficile infection. Studies show that the gut microbiota plays an important role in the pathophysiology of neurological and psychiatric disorders through the microbiota-gut-brain axis. Therefore, reconstruction of the healthy gut microbiota is a promising new strategy for treating cerebral diseases. We have reviewed the latest research on the role of gut microbiota in different nervous system diseases as well as FMT in the context of its application in neurological, psychiatric, and other nervous system-related diseases (Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, epilepsy, autism spectrum disorder, bipolar disorder, hepatic encephalopathy, neuropathic pain, etc.).
Rapid Screening and Quantitative Analysis of 74 Pesticide Residues in Herb by Retention Index Combined with GC-QQQ-MS/MS
Authors: Tan Peng , Xu Li , Wei Xi-Chuan , Huang Hao-Zhou , Zhang Ding-Kun , Zeng Chen-Juan , Geng Fu-Neng , Bao Xiao-Ming , Hua Hua , Zhao Jun-Ning
Published: January 2021

In this research, a very practical QuEChERS-GC-MS/MS analytical approach for 74 pesticide residues in herb based on retention index was established. This novel analytical approach has two important technical advantages. One advantage is to quickly screen pesticide compounds in herbs without having to use a large number of pesticide standard substances at the beginning of the experiment. The other advantage is to assist in identifying the target pesticide compound accurately. A total of 74 kinds of pesticides were quickly prescreened in all chuanxiong rhizoma samples. The results showed that three kinds of pesticides were screened out in all the samples, including chlorpyrifos, fipronil, and procymidone, and the three pesticides were qualitatively and quantitatively determined. The RSD values for interday and intraday variation were acquired to evaluate the precision of the analytical approach, and the overall interday and intraday variations are not more than 1.97% and 3.82%, respectively. The variations of concentrations of the analyzed three pesticide compounds in sample CX16 are 0.74%–4.15%, indicating that the three pesticides in the sample solutions were stable in 48 h. The spiked recoveries of the three pesticides are 95.22%, 93.03%, and 94.31%, and the RSDs are less than ± 6.0%. The methodological verification results indicated the good reliability and accuracy of the new analytical method. This research work is a new application of retention index, and it will be a valuable tool to assist quickly and accurately in the qualitative and quantitative analysis of multipesticide residues in herbs.
Sharing Logistics Service Supply Chain with Revenue-Sharing vs. Cost-Sharing Contracts
Authors: Luo Ying , Wei Qiang , Gou Xinyu , Dai Dai , Zhou Yiran
Published: January 2021

The purpose of this study is to explore the design of equity cooperation mechanism in the sharing logistics service supply chain. This study designs a two-echelon logistics service supply chain composed of an urban joint distribution company and N logistics companies. The urban joint distribution company is jointly established by N logistics companies based on specific shares of equity investment. We establish sharing logistics service supply chain models under revenue-sharing or cost-sharing contracts. Revenue-sharing factor or cost-sharing factor is the equity cooperation parameter. When the members of the supply chain choose to cooperate in revenue-sharing or cost-sharing mechanism, not all cooperation scenarios considered in the study can achieve Pareto improvement of the total profit of the supply chain, but at least one situation can achieve Pareto improvement. This study provides feasible solutions for logistics companies to join the sharing logistics service platform and provides a reference for the operation of a joint distribution platform established by logistics companies. New results and managerial insights are derived by the sharing logistics service supply chain with revenue-sharing vs cost-sharing contracts, which enriches the interfaces of the operation of the sharing logistics service supply chain.
Hydrogen Gas: A Novel Type of Antioxidant in Modulating Sexual Organs Homeostasis
Authors: Zhang Yaxing , Liu Haimei , Xu Jinwen , Zheng Shuhui , Zhou Lequan
Published: January 2021

Sex is a science of cutting edge but bathed in mystery. Coitus or sexual intercourse, which is at the core of sexual activities, requires healthy and functioning vessels to supply the pelvic region, thus contributing to clitoris erection and vaginal lubrication in female and penile erection in male. It is well known that nitric oxide (NO) is the main gas mediator of penile and clitoris erection. In addition, the lightest and diffusible gas molecule hydrogen (H2) has been shown to improve erectile dysfunction (ED), testis injuries, sperm motility in male, preserve ovarian function, protect against uterine inflammation, preeclampsia, and breast cancer in female. Mechanistically, H2 has strong abilities to attenuate excessive oxidative stress by selectively reducing cytotoxic oxygen radicals, modulate immunity and inflammation, and inhibit injuries‐induced cell death. Therefore, H2 is a novel bioactive gas molecule involved in modulating sexual organs homeostasis.
Three Configurations of Compact Planar Multistub Microstrip Antennas for mmW Mobile Applications
Authors: Lak Asma , Adelpour Zahra , Oraizi Homayoon , Parhizgar Naser
Published: January 2021

Three configurations of compact planar multistub antennas are proposed in the frequency range of 27–29.5 GHz as candidates for the 5G standard frequency band. Each antenna consists of the same feeding part configuration but different structures for the dipole, director, and reflector parts. The feeding part is based on the substrate integrated waveguide (SIW) technology which results in compact size. The TE10 dominant mode is considered in the design procedure by HFSS software simulations. The proposed antennas have been simulated, fabricated, and measured (for S11, E, and H pattern). The simulation and measurement results show reasonable agreement for S11 and radiation patterns of E- and H-planes and impedance bandwidths. Moreover, for specific absorption rate (SAR) estimation, a three-layer human head model (skin, skull, and brain) is placed next to the antennas as the exposure source. The simulation results show the performance of the proposed antennas for low-SAR, which make them good candidates for safe usage concerning the negative impact of millimeter waves (mmWs) on human health. Finally, a comparison table is presented which verifies the compact size of our proposed antennas.
Advances in Quantitative Analysis of 18F-Sodium Fluoride Coronary Imaging
Authors: Kwiecinski Jacek , Lassen Martin Lyngby , Slomka Piotr J.
Published: January 2021

18F-sodium fluoride (18F-NaF) positron emission tomography (PET) has emerged as a promising noninvasive imaging tool for the assessment of active calcification processes in coronary artery disease. 18F-NaF uptake colocalizes to high-risk and ruptured atherosclerotic plaques. Most recently, 18F-NaF coronary uptake was shown to be a robust and independent predictor of myocardial infarction in patients with advanced coronary artery disease. In this review, we provide an overview of the advances in coronary 18F-NaF imaging. In particular, we discuss the recently developed and validated motion correction techniques which address heart contractions, tidal breathing, and patient repositioning during the prolonged PET acquisitions. Additionally, we discuss a novel quantification approach—the coronary microcalcification activity (which has been inspired by the widely employed method in oncology total active tumor volume measurement). This new method provides a single number encompassing 18F-NaF activity within the entire coronary vasculature rather than just information regarding a single area of most intense tracer uptake.
Eye-Tracking Technology in Online Real Estate Rental
Authors: Sun Jie , Wang Zhiruo , Dang Xiaoyi , Zhang Yang
Published: January 2021

In China in recent years, the rental housing market has boomed, but insufficient attention has been paid to microsubject tenants in the market, and there is a lack of research results on tenants’ decision-making processes. In keeping with the characteristics of China’s accommodation-renting population, this study takes as its research object graduating students, who form an important group in the housing rental market, and focuses on the information retrieval process underlying prospective tenants’ rental decisions. First, it investigates tenants’ concerns during the renting process by means of questionnaires. Second, using eye-tracking experiments, the real online renting process is simulated and tenants’ web listings are analyzed qualitatively and quantitatively. In the process of information search, the characteristics and rules of browsing the entry search page, the listings page, and the details page are obtained, and the factors that prospective tenants pay attention to in their search for rental information are obtained. The research results show that initial alphabetical sorting of the term search page can improve the subjects’ efficiency in locating the target keywords, the text information display area of the listings page receives more attention than others, and the real concern factors of the tenants on the page listing details are generally consistent with their selected factors but deviate slightly. Finally, the layout and display of web page information affect how subjects’ attention is distributed, and web page information presents a significant difference in attention between upper and lower pages.
Sutureless Intrascleral Posterior Chamber Intraocular Lens Fixation: Analysis of Clinical Outcomes and Postoperative Complications
Authors: Liu Jiannan , Fan Wenxue , Lu Xinyu , Peng Shaomin
Published: January 2021

Purpose. To report a technique for performing sutureless intrascleral fixation of a posterior chamber intraocular lens (PC-IOL) and analyzing the clinical outcomes and postoperative complications. Study Design. 68 eyes of 66 patients who received the technique were studied retrospectively. Methods. The best-corrected visual acuity (BCVA), intraocular pressure (IOP), anterior chamber depth (ACD), IOL tilt and decentration, corneal topography (K1 and K2), and postoperative complications were determined at 3 months. Results. The mean preoperative BCVA was 1.63 ± 1.24 logMAR units, and the mean postoperative BCVA was 0.74 ± 0.59 logMAR units at 3 months (P<0.05). The mean preoperative IOP was 21.9 ± 12.6 mmHg, and the mean postoperative IOP was 16.9 ± 4.5 mmHg at 3 months (P = 0.001). The mean preoperative corneal topography (K1 and K2) was K1 = 42.14 ± 1.91 and K2 = 43.54 ± 1.51; the mean postoperative corneal topography (K1 and K2) was K1 = 43.03 ± 2.18 and K2 = 43.40 ± 1.71 at 3 months (P = 0.678 and 0.468, respectively). The mean preoperative spherical equivalent was +11.00 ± 13.19 diopters (D), and the mean postoperative spherical equivalent was +0.06 ± 0.86 D (P<0.005). The mean IOL tilt was 2.4 ± 1.7°, and the mean decentration was 0.35 ± 0.21 mm. The mean ACD was 4.31 ± 0.29 mm. Conclusions. The 27-gauge sutureless intrascleral PC-IOL implantation technique minimizes intraoperative injury, simplifies procedure, and provides good PC-IOL fixation with few postoperative complications.
Motion Control of a 4WS4WD Path‐Following Vehicle: Dynamics‐Based Steering and Driving Models
Authors: Zhang Zhonghua , Yang Caijin , Zhang Weihua , Xu Yanhai , Peng Yiqiang , Chi Maoru
Published: January 2021

This paper deals with a four‐wheel‐steering four‐wheel‐driving (4WS4WD) vehicle under the path‐following control. Focuses are placed on the motion control of the vehicle, and the drive forces and steering angles for achieving accurate path‐following by the vehicle are determined. In this research, a nonlinear vehicle model of three degrees of freedom (DOFs) is used. The vehicle path‐following dynamics are modeled using the classical mass‐damper‐spring vibration theory, which is described by three ordinary differential equations of second order with lateral, heading and velocity deviations, and control parameters. Combined with the vehicle path‐following dynamic model, the nonlinear vehicle dynamic model is decoupled in generalized coordinate space. The required drive forces and steering angles for the vehicle path‐following controllers are thus calculated and control models are obtained. Theoretical analysis for steering and driving control models is also carried out. It discloses that control models can maintain good performance against uncertainties. The vehicle path‐following control is exhibited by dynamic simulation in CarSim with consideration of a complex vehicle model and a variable‐curvature planned path. Numerical results obtained are analyzed and show control models have capable of dealing with a complex path‐following problem. This paper provides a new insight into understanding path‐following control of a 4WS4WD vehicle at the generalized vibration level.
Robust

H

∞

Control for the Nonlinear Cascade Systems with Passive and Nonpassive Subsystems
Authors: Zhao Hongpeng , Wang Xingtao
Published: January 2021

In this paper,

H

∞

control for the uncertain switched nonlinear cascade systems with passive and nonpassive subsystems is investigated. Based on the average dwell time method, for any given passivity rate, average dwell time, and disturbance attenuation level, the feedback controllers of the subsystems by predetermined constants are designed to solve the exponential stability and

L

2

-gain problems of

H

∞

control for switched nonlinear cascade systems. Two examples are provided to demonstrate the effectiveness of the proposed design method.
A Unique Presentation of Bouveret’s Syndrome: Two Large Gallstones Obstructing Both the Gastric Outlet and the Common Bile Duct Simultaneously
Authors: Tian Yuqian , Sarvepalli Neha , Nazzal Mustafa
Published: January 2021

Bouveret’s syndrome refers to a gastric outlet obstruction secondary to impaction of a gallstone in the pylorus or proximal duodenum. Thus, it can be considered a very proximal form of gallstone ileus and is infrequent. We describe such a unique case that a female patient presents with Bouveret’s syndrome and concomitant common bile duct obstruction by a second gallstone. The decision over its surgical management is complicated, based on risk factors, clinical presentations, radiographic evidence, surgical risk assessment, and specific considerations tailored to individual case. Because of her stable clinical picture and low surgical risk, we proceeded with stone extractions, fistula take-down, and common bile duct exploration in a one-stage procedure. Her postoperative course was complicated by bile stained drainage through closed suction drain that resolved with conservative management.
Hemorrhage of the Ramus Lumbalis of the Iliolumbar Artery as a Cause for Shock in Blunt Trauma Victims on Therapeutic Anticoagulation
Authors: Sullivan Thomas Patrick , Smith-Singares Eduardo
Published: January 2021

Noncavitary torso hemorrhage is a rare and poorly characterized injury that can lead to exsanguination if not promptly addressed. When present in a high-risk patient on therapeutic anticoagulation, it can lead to a swift fatal outcome. Two cases (an 80-year-old female on warfarin and a 67-year-old male on apixaban for atrial fibrillation) presented with shock after direct blunt trauma in their torsos. Embolotherapy techniques were utilized to obtain angiostasis while the patients were resuscitated with massive transfusion protocols and reversal of the agents received. In the setting of severe localized blunt trauma on an aging victim while on antithrombotic medications, noncavitary torso hemorrhage must be included in the differential diagnosis. Local expertise and a high level of suspicion were critical in the early intervention, and postprocedural management of the injuries sustained and secured a good result.
Effects of Heat Addition on Wave Drag Reduction of a Spiked Blunt Body
Authors: Wang Hongyu , Yang Yanguang , Li Langquan , Wang Gang , Zhang Qinghu
Published: January 2021

Drag reduction technology plays a significant role in extending the flight range for a high-speed vehicle. A wave drag reduction strategy via heat addition to a blunt body with a spike was proposed and numerically validated. The heat addition is simulated with continuous heating in a confined area upstream of the blunt body. The effects of heat addition on drag reduction in three flow conditions (

M
=
3.98
,
5
,
6

) were compared, and the influence of power density

q

h

(

q

1

=
2.0
×

10

8

 
W
/

m

3

,

q

2

=
5.0
×

10

8

 
W
/

m

3

, and

q

3

=
1.0
×

10

9

 
W
/

m

3

) of heating was evaluated. Results show that the heat addition has a positive way to reduce the drag of the body with a spike alone, and more satisfactory drag reduction effectiveness can be achieved at a higher Mach number. The drag reduction coefficient increases with

q

h

in the same flow condition, with a maximum of 38.9% (

M
=
6

) as

q

3

=
1.0
×

10

9

 
W
/

m

3

. The wave drag reduction principle was discussed by a transient calculation, which indicates that the separation region has entrainment of the heated air and expanded with its sonic line away from the blunt cone, which results in an alleviation of the pressure load caused by shock/shock interaction.
Quantitation of Apremilast in Beagle Dogs Plasma by UPLC-MS-MS and Its Application to Pharmacokinetic Studies
Authors: Xiong Wei , Wang Ling , Zhang Haiyan , Tao Xiaoqiu , Jiang Xuehua , Liu Zejuan , Zhao Jiajia , Xu Wenwen
Published: January 2021

A sensitive and selective ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS-MS) method for the determination of apremilast in beagle dog plasma has been developed and successfully validated in the current study. Clopidogrel was employed as an internal standard (IS), and liquid-liquid extraction by tert-butylmethyl ether was used for sample preparation. Chromatographic separation was achieved on a UPLC BEH Shield RP18 column (50 mm × 2.1 mm, 1.7 μm) with 5 mM ammonium formate water and 5 mM ammonium formate methanol as the mobile phase with gradient elution. Calibration plots were linear in the range of 2–3000 ng/mL for apremilast in beagle dog plasma. Mean recoveries of apremilast in beagle dogs plasma ranged from 87.4% to 97.4%. The intrarun and interrun precision was less than 6% and 9%, respectively, with the accuracy between 92.4% and 101.1%. The method has also been successfully applied in the pharmacokinetics study of apremilast. The mean t1/2Z was 5.41 h for 30 mg·day−1 for beagle dogs after oral administration. The AUC0-t increased linearly from 3.51 to 1802.13 

μ
g
 

L

−
1

∗
h

after administration of single doses.
Prevalence of Intestinal Parasites and Salmonella typhi among Food Handlers Working in Catering Establishments of Public Institutes Found in Dawuro Zone, South-Western Ethiopia
Authors: Kumalo Abera , Gambura Eyasu , Dodicho Terfe , Ahmed Khawaja Shakeel , Balcha Tamrat , Beshir Bahailu , Abraham Misrak
Published: January 2021

Background. Food borne disease, which is the result of ingestion of foodstuffs contaminated with microorganisms, parasites, or chemicals, encompasses a wide spectrum of illness and public health problem worldwide. Ethiopia is placed on second, third, and fourth position due to the highest burden of ascariasis, hookworm, and trichuriasis, respectively, in sub-Saharan Africa. The present study is aimed at determining the prevalence of Salmonella typhi and intestinal parasites among food handlers working in catering establishments of public institutes found in Dawuro Zone, South-Western Ethiopia. Methods. A cross-sectional study is conducted among food handlers working in catering establishments of public institutions found in Dawuro Zone from March to July 2019. The data was collected by using pretested structured questionnaires. Stool and blood samples were taken from each participant for parasitic examinations concurrently using direct and modified formol ether concentration wet smear techniques and Widal test by slide test and tube serial dilution technique, respectively. The data entered into Epi info version 3.5.1 and then exported into SPSS window version 20.0 for analysis. Logistic regressions were performed to assess the association between binary outcomes and different explanatory variables.

P

value <0.05 was considered statistically significant. Result. The study included 402 (293 females and 109 males) food handlers. Of 402 stool specimens, 20.4% were found to be positive for different parasite species, comprising protozoa (35.9%) and helminths (64.1%). A. lumbricoides was the most prevalent parasite (8.0%), followed by E. histolytica/dispar (4.23%). Twenty-six (6.5%) of food handlers were positive for Widal test.

Ages
≥
40

years (AOR: 0.436; 95% CI: 0.203, 0.937), attending no education (AOR: 2.142; 95% CI: 1.048, 4.378), not washing hands after using latrine (AOR: 4.355; 95% CI: 1.771, 10.708), not covering mouth with tissue paper (AOR: 0.530; 95% CI: 0.312, 0.899), no medical checkup (in the last four months) (AOR: 0.278; 95% CI: 0.116, 0.667), and untrimmed fingernails (AOR: 0.382; 95% CI: 0.229, 0.635) were significantly associated with intestinal parasitic or Salmonella typhi infections. Conclusion. The prevalence of intestinal parasitic infection (IPI) and Salmonella among food handlers in the present study is relatively high compared to other different studies conducted in developed and developing countries. Therefore, biannually screening of food handlers for intestinal parasites (IPs) and periodic deworming of infected cases along with provision of food safety measures focusing on personal hygiene and environmental sanitation are recommended to control the parasitic infection in food handlers.
Use of Pre- and Intensified Postprocedural Physiotherapy in Patients with Symptomatic Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement Study (the 4P-TAVR Study)
Authors: Weber M. , Klein U. , Weigert A. , Schiller W. , Bayley-Ezziddin V. , Wirtz D. C. , Welz A. , Werner N. , Grube E. , Nickenig G. , Sinning J.-M. , Ghanem A.
Published: January 2021

Background. Physiotherapy prior to open-heart surgery lowers the rate of pneumonia and length of the hospital stay. Pneumonia is a major contributor to short-term mortality following transcatheter aortic valve replacement (TAVR). Hence, we hypothesized that pre- and intensified postprocedural physiotherapy in patients undergoing TAVR might impact the net functional and clinical outcome. Methods and Results. The 4P-TAVR study was a prospective, monocentric, randomized trial. The study was designed to compare the efficacy and safety of intensified periprocedural physiotherapy including inspiratory muscle training versus standard postprocedural physiotherapy. Patients were randomized in a 1 : 1 fashion. 108 patients were included and followed up for 90 days after TAVR. While patients in group A (control group: 50 patients, age: 81.7 ± 5.0 years, 52% male) did not receive physiotherapy prior to TAVR, group B (intervention group: 58 patients, age: 82.2 ± 5.82 years, 47% male) participated in intensive physiotherapy. Compared to the control group, patients in the interventional group showed a lower incidence of postinterventional pneumonia (10 [20.0%] vs. 3 [5.1%],

p
=
0.016

) and had a 3-day shorter mean hospital stay (13.5 ± 6.1 days vs. 10.1 ± 4.7 days,

p
=
0.02

). The primary composite endpoint of mortality and rehospitalization was not different between the groups. Conclusion. Intensified physiotherapy is safe and has positive effects on clinical outcomes up to 90 days after TAVR but has no impact on the primary combined endpoint of mortality and rehospitalization. Longer follow-up, a multicenter design, and a higher number of subjects are needed to confirm these preliminary results. This trial is registered with DRKS00017239.
Maximum Likelihood-Based Measurement Noise Covariance Estimation Using Sequential Quadratic Programming for Cubature Kalman Filter Applied in INS/BDS Integration
Authors: Gao Bingbing , Hu Gaoge , Li Wenmin , Zhao Yan , Zhong Yongmin
Published: January 2021

With the completion of the Beidou-3 system (BDS) in China, INS/BDS integration will become a promising navigation and positioning strategy. However, due to the nonlinear propagation characteristic of INS error and inevitable involvement of inaccurate measurement noise statistics, it is difficult to achieve the optimal solution through the INS/BDS integration. This paper proposes a method of cubature Kalman filter (CKF) with the measurement noise covariance estimation by using the maximum likelihood principle to solve the abovementioned problem. It establishes an estimation model for measurement noise covariance according to the maximum likelihood principle, and then, its estimation is calculated by utilizing the sequential quadratic programming. The estimated measurement noise covariance will be fed back to the procedure of CKF to improve its adaptability. Simulation and comparison analysis verify that the proposed method can accurately estimate measurement noise covariance to effectively restrain its influence on navigation solution, leading to improved navigation performance for the INS/BDS integration.
Dynamic Evolution Game of Travelers’ Air-to-HSR Choice under the Scenario of HSR Speed-Up
Authors: Mou Zhenhua , Yan Kangli , Li Kepeng , Shen Dongfu , Li Xiang , Wang Hanbing , Guo Jijie , Chen Yanyan
Published: January 2021

With the technological advancement, China’s high-speed rail (HSR) has achieved a higher running speed than ever before, which at the same time leads to the intensive competition between air and high-speed rail with trips within 500–1000 km, as well as to the significant changes of travelers’ air-to-HSR choice. In order to explore the dynamic adaptation of travelers’ choice of high-speed rail (HSR) and air in the case of HSR speed-up, a logit dynamics model of travelers’ choice based on evolutionary game was constructed to describe the evolution of travelers’ choice. With HSR-air travel time and the ticket price of origin-destination (OD) points of Beijing-Shanghai as the benchmark, the study set up two scenarios of HSR speed-up and compared and analyzed their payoffs in value. On the basis of mathematical simulation, the travelers’ “air-to-HSR choice” and the change of competition range under the background of HSR speed-up were both discussed. The result indicated that the HSR speed-up would attract more travelers, and its share rate would rise to 58.31% and 72.73%, respectively, with HSR running speed increasing to 400 and 600 km/h; the marginal utility of HSR speed-up is more obvious, and in the meantime, the increase of HSR running speed extends the intense HSR-air competition range to longer-distance travels. In the case of HSR speed-up, travelers’ choice changes as well. The HSR operators themselves should formulate reasonable ticket prices and improve their management. At the same time, the air operators should adjust their operation plan in time.
Habitation Altitude and Left Ventricular Diastolic Function: A Population‐Based Study
Authors: Zheng Congyi , Wang Xin , Tang Haosu , Chen Zuo , Zhang Linfeng , Wang Su , Kang Yuting , Yang Ying , Jiang Linlin , Huang Gang , Wang Zengwu
Published: January 2021

Background

Although numerous studies have been published evaluating the positive or negative effects of altitude on cardiovascular disease, many of them are conflicting.

Methods and Results

Data come from 2 cross‐sectional surveys using a similar method in China; and a total of 34 215 residents, aged ≥35 years, were eligible and recruited in the study. Left ventricular diastolic dysfunction (LVDD), according to the 2009 American Society of Echocardiography guidelines, was defined and evaluated. Altitude was divided into low (<1500 m), middle (1500–3500 m), and high (≥3500 m) level groups. Among the 34 215 participants (aged 55.87 years; men, 45.92%; altitude ranging from 3.1 ~ 4507 m), 15 099 (crude prevalence, 44.13%), 517 (crude prevalence, 1.51%), and 272 (crude prevalence, 0.79%) were diagnosed as having grades I, II, and LVDD, respectively. Compared with low‐level group, the odds ratios (ORs) (95% CIs) of LVDD for middle‐ and high‐level groups were 1.65 (1.49–1.82) and 1.89 (1.63–2.19), respectively (
P
trend
<0.001). The ORs (95% CI) were 1.43 (1.31–1.56) and 2.03 (1.67–2.47) per 500‐m increment for middle‐ and high‐level groups. There was a nonlinear relationship (upward‐sloping “W” shape) between altitude and the risk of LVDD, assessed by the restricted cubic spline. For each LVDD grade, ORs (95% CIs) of grade I LVDD for middle‐ and high‐level groups were 1.75 (1.59–1.92) and 1.95 (1.69–2.25), respectively; for grade II, ORs (95% CIs) for middle‐ and high‐level groups were 6.19 (3.67–10.42) and 5.27 (2.18–12.74), respectively. The stratified analyses indicated that LVDD was much more remarkably influenced by elevated altitude in men (
P
interaction
=0.0019).

Conclusions

Higher altitude is associated with increased risk of LVDD among people living over 1500 m, especially for men.
Sweet, sweet language: Prakrit and Maṇipravāḷam in premodern Kerala
Authors: Goren-Arzony Sivan
Published: January 2021

This paper studies the connections between Prakrit and early Maṇipravāḷam literature from premodern Kerala. Maṇipravāḷam (literally, ‘gems and corals’) is the emic term for a dominant part of Kerala’s premodern vernacular literature, binding together Kerala’s local language and Sanskrit. As a highly Sanskritised register of a Dravidian language, Maṇipravāḷam has generally been viewed as having been inspired and influenced by either Sanskrit or Tamil literature, grammar, and poetics. This paper, however, highlights a rarely discussed aspect: the role of Prakrit in shaping both Maṇipravāḷam literature and theory. I discuss the relation between Prakrit and Maṇipravāḷam in two connected ways: first, by considering the similarities between the practices themselves, especially in terms of their themes and aesthetics; and second, by examining the implicit ways in which Maṇipravāḷam theory, as it is presented in the Līlātilakam, Kerala’s first grammar and work on poetics, is structured on Prakrit materials or on Sanskrit materials dealing with Prakrit.