bluuebunny/crossref_metadata_2025 huggingface dataset:
General anaesthesia-related complications of gut motility with a focus on cholinergic mechanisms, TRP channels and visceral pain
Authors: Zholos Alexander V. , Dryn Dariia O. , Melnyk Mariia I.
Published: May 2023

General anesthesia produces multiple side effects. Notably, it temporarily impairs gastrointestinal motility following surgery and causes the so-called postoperative ileus (POI), a multifactorial and complex condition that develops secondary to neuromuscular failure and mainly affects the small intestine. There are currently limited medication options for POI, reflecting a lack of comprehensive understanding of the mechanisms involved in this complex condition. Notably, although acetylcholine is one of the major neurotransmitters initiating excitation-contraction coupling in the gut, cholinergic stimulation by prokinetic drugs is not very efficient in case of POI. Acetylcholine when released from excitatory motoneurones of the enteric nervous system binds to and activates M2 and M3 types of muscarinic receptors in smooth muscle myocytes. Downstream of these G protein-coupled receptors, muscarinic cation TRPC4 channels act as the major focal point of receptor-mediated signal integration, causing membrane depolarisation accompanied by action potential discharge and calcium influx via L-type Ca2+ channels for myocyte contraction. We have recently found that both inhalation (isoflurane) and intravenous (ketamine) anesthetics significantly inhibit this muscarinic cation current (termed mICAT) in ileal myocytes, even when G proteins are activated directly by intracellular GTPγS, i.e., bypassing muscarinic receptors. Here we aim to summarize Transient Receptor Potential channels and calcium signalling-related aspects of the cholinergic mechanisms in the gut and visceral pain, discuss exactly how these may be negatively impacted by general anaesthetics, while proposing the receptor-operated TRPC4 channel as a novel molecular target for the treatment of POI.
Unraveling the genetic potential of native rice (Oryza sativa L.) landraces for tolerance to early-stage submergence
Authors: Shanmugam Aravindan , Manivelan Kalaiarasan , Deepika Konne , Nithishkumar Gopal , Blessy Viswanadhapalli , Monihasri Raju Baskaran , Nivetha Dhanasekar , Roshini Arunkamaraj , Sathya Palanivelu , Pushpa Raman , Manimaran Rangarajan , Subrahmaniyan Kasirajan , Sassikumar Datchinamoorthy , Suresh Ramalingam
Published: May 2023

Direct-seeded rice (DSR) is a promising alternative to the traditional puddled rice system. It has become more popular among rice growers as a result of socioeconomic shifts and global climate change. Although DSR offers advantages, rice plants experience greater anaerobic stress at sowing from unpredicted rainfall. Rice is unique among cereals in its ability to germinate under anaerobiosis. The coleoptile of rice rapidly elongates above the water surface to obtain more oxygen and enhance vigorous seedling growth. A panel of 115 landraces and four check varieties were subjected to anaerobic stress with a water level of 10 cm for up to 15 days. The present study observed significant variation in anaerobic germination percentage (AGP) (10%–100%) and anaerobic vigor index (AVI) (150–4,433). Landraces Karuthakar, Poovan samba, Mattaikar, Edakkal, Manvilayan, and Varappu kudainchan were identified as genotypes tolerant to early water submergence. The shoot and root length of susceptible landraces were significantly lower than the tolerant landraces under hypoxia condition, implying that landraces with longer shoots and roots had a higher survival rate. The response index substantiated this. The results clearly show that tolerant and moderately tolerant landraces possessed higher mean values for root and shoot lengths than susceptible landraces. The landraces grouped under the long–bold category had superior AGP and AVI scores to other grain type groups. This raises the possibility that differences in kernel breadth, which is linked to grain type, could affect anaerobic germination potential. Molecular confirmation using gene-specific markers, viz., DFR, TTP_G4, RM478, RM208, and RM24161, for which the polymorphic information content (PIC) value ranged from 0.36 (RM478) to 0.68 (RM206) suggests that this diverse panel of landraces must be assessed further using advanced molecular tools to precisely clarify the genetic mechanism behind this phenomenon. The tolerant landraces thus identified may become donors in breeding programs. The introduction of these traits would contribute to the development of rice varieties tolerant to anaerobic stress, resulting in sustainable yields. This solution could promote the DSR system across the world.
Seed dormancy loss from dry after-ripening is associated with increasing gibberellin hormone levels in Arabidopsis thaliana
Authors: Nelson Sven K. , Kanno Yuri , Seo Mitsunori , Steber Camille M.
Published: May 2023

Introduction

The seeds of many plants are dormant and unable to germinate at maturity, but gain the ability to germinate through after-ripening during dry storage. The hormone abscisic acid (ABA) stimulates seed dormancy, whereas gibberellin A (GA) stimulates dormancy loss and germination.

Methods

To determine whether dry after-ripening alters the potential to accumulate ABA and GA, hormone levels were measured during an after-ripening time course in dry and imbibing ungerminated seeds of wildtype Landsberg erecta (Ler) and of the highly dormant GA-insensitive mutant sleepy1-2 (sly1-2).

Results

The elevated sly1-2 dormancy was associated with lower rather than higher ABA levels. Ler germination increased with 2-4 weeks of after-ripening whereas sly1-2 required 21 months to after-ripen. Increasing germination capacity with after-ripening was associated with increasing GA4 levels in imbibing sly1-2 and wild-type Ler seeds. During the same 12 hr imbibition period, after-ripening also resulted in increased ABA levels.

Discussion

The decreased ABA levels with after-ripening in other studies occurred later in imbibition, just before germination. This suggests a model where GA acts first, stimulating germination before ABA levels decline, and ABA acts as the final checkpoint preventing germination until processes essential to survival, like DNA repair and activation of respiration, are completed. Overexpression of the GA receptor GID1b (GA INSENSITIVE DWARF1b) was associated with increased germination of sly1-2 but decreased germination of wildtype Ler. This reduction of Ler germination was not associated with increased ABA levels. Apparently, GID1b is a positive regulator of germination in one context, but a negative regulator in the other.
Improved multi-trait prediction of wheat end-product quality traits by integrating NIR-predicted phenotypes
Authors: Azizinia Shiva , Mullan Daniel , Rattey Allan , Godoy Jayfred , Robinson Hannah , Moody David , Forrest Kerrie , Keeble-Gagnere Gabriel , Hayden Matthew J. , Tibbits Josquin FG. , Daetwyler Hans D.
Published: May 2023

Historically, end-product quality testing has been costly and required large flour samples; therefore, it was generally implemented in the late phases of variety development, imposing a huge cost on the breeding effort and effectiveness. High genetic correlations of end-product quality traits with higher throughput and nondestructive testing technologies, such as near-infrared (NIR), could enable early-stage testing and effective selection of these highly valuable traits in a multi-trait genomic prediction model. We studied the impact on prediction accuracy in genomic best linear unbiased prediction (GBLUP) of adding NIR-predicted secondary traits for six end-product quality traits (crumb yellowness, water absorption, texture hardness, flour yield, grain protein, flour swelling volume). Bread wheat lines (1,400–1,900) were measured across 8 years (2012–2019) for six end-product quality traits with standard laboratory assays and with NIR, which were combined to generate predicted data for approximately 27,000 lines. All lines were genotyped with the Infinium™ Wheat Barley 40K BeadChip and imputed using exome sequence data. End-product and NIR phenotypes were genetically correlated (0.5–0.83, except for flour swelling volume 0.19). Prediction accuracies of end-product traits ranged between 0.28 and 0.64 and increased by 30% through the inclusion of NIR-predicted data compared to single-trait analysis. There was a high correlation between the multi-trait prediction accuracy and genetic correlations between end-product and NIR-predicted data (0.69–0.77). Our forward prediction validation revealed a gradual increase in prediction accuracy when adding more years to the multi-trait model. Overall, we achieved genomic prediction accuracy at a level that enables selection for end-product quality traits early in the breeding cycle.
Psychological predictors of risky driving: the role of age, gender, personality traits (Zuckerman’s and Gray’s models), and decision-making styles
Authors: Aluja Anton , Balada Ferran , García Oscar , García Luis F.
Published: May 2023

The present study was planned to study the relationships between age, personality (according to Zuckerman’s and Gray’s psychobiological models) and decision-making styles in relation to risky driving behaviors. The participants were habitual drivers, 538 (54.3%) men and 453 (45.7%) women, with a mean age around 45 years and mainly of middle socioeconomic status. The results indicate that the youngest men and women reported more Lapses, Ordinary violations, and Aggressive violations than the oldest men and women. Women reported more Lapses (d = −0.40), and men more Ordinary (d = 0.33) and Aggressive violations (d = 0.28) when driving. Linear and non-linear analysis clearly support the role of both personality traits and decision-making styles in risky driving behaviors. Aggressiveness, Sensitivity to Reward, Sensation Seeking played the main role from personality traits, and Spontaneous and Rational decision-making style also accounted for some variance regarding risky driving behaviors. This pattern was broadly replicated in both genders. The discussion section analyses congruencies with previous literature and makes recommendations on the grounds of observed results.
Exploring the effect of the Group Size and Feedback of non-player character spectators in virtual reality exergames
Authors: Xu Wenge , Yu Kangyou , Meng Xuanru , Monteiro Diego , Kao Dominic , Liang Hai-Ning
Published: May 2023

Despite the widespread interest in leveraging non-player characters (NPCs) to enhance gameplay experiences, there is a gap in understanding of how NPC spectators (i.e., those virtual characters in the scene that watch users' actions) affect players. For instance, the impact of NPC spectators' presence and feedback on players' performance and experience has not been studied, especially in virtual reality (VR) exergames. This paper aims to fill this gap and reports two user studies that assess their effect on such games. Study 1 explored the impact of having NPC spectators present and their feedback available in a gesture-based VR exergame and found having NPC spectators and their feedback could improve players' game performance, experience, and exertion. Based on Study 1's results, we further explored two characteristics of the spectators—their group size (small/large) and their feedback (with/without). The results show that (1) a large spectator number is more helpful since it improves the overall game experience (higher competence, flow, immersion), increases AvgHR% (the average heart rate percentage divided by the maximum heart rate), and enhances performance (improved players' combo performance and increased gesture success rate for particular gesture); (2) spectator feedback is instrumental in improving players' performance (higher gesture success rates, more combos performed successfully, more monster's combos prevented), enhancing game experience (positive affect, competence, flow, and immersion), and reducing negative game experience, increasing exertion (AvgHR% and burned more calories). Based on the results, we derived two main design recommendations for VR exergames that could pave the way for improving gameplay performance and game experience, especially among young adults.
Gender differences in perceived legitimacy and status perception in leadership role
Authors: Cha Hyunjin , Uchida Yukiko , Choi Eunsoo
Published: May 2023

The present study examined the difference between women and men in perceiving leadership roles. Two experiments, one conducted online and the other in a lab, investigated the subjective experiences of Japanese men and women when they are assigned with different roles (e.g., leader vs. subordinate). Both studies revealed that women perceived their role as less legitimate when they were assigned leader role (vs. subordinate role). In contrast, men did not differ in their perceived legitimacy according to the assigned roles. This discrepancy in legitimacy perception in response to different roles between men and women accounted for a significant variance in women’s lower sense of status when they were a leader (vs. subordinate), but not among men. Our study results illustrate the psychological barrier operating for women in organizations that are embedded in a cultural context in which women leaders are highly underrepresented.
Technology evaluations are associated with psychological need satisfaction across different spheres of experience: an application of the METUX scales
Authors: Burnell Ryan , Peters Dorian , Ryan Richard M. , Calvo Rafael A.
Published: May 2023

Introduction

Digital technologies have the capacity to impact psychological wellbeing in both positive and negative ways. Improving technologies with respect to wellbeing requires nuanced understanding of this impact and reliable ways to measure it. Here, we aim to further this understanding by investigating the relations between psychological needs and people's evaluations of technologies (with respect to satisfaction, usability, and measures of value).

Method

Across two studies with 1,521 participants, we improved and validated four scales that were first put forward as part of the METUX model of technology interaction. These scales measure psychological needs in the life, behavior, task, and interface spheres of experience. We applied these scales to four separate technologies (Facebook, TikTok, Blackboard, and Moodle), and examined the relationships between people's need satisfaction and frustration in the four spheres of experience and their overall evaluations of the technologies.

Results and discussion

Each of the four scales had good psychometric properties across the four technologies. For each sphere of experience, psychological need satisfaction and frustration were associated with standard measures of usability and user satisfaction, and correlation patterns supported the METUX model and its approach to differentiating spheres of technology experience.
Burnout of emergency nurses in a South African context: the role of job demands and resources, and capabilities
Authors: Barnard Neil B. , Rothmann Sebastiaan , De Beer Leon T. , Lubbe Welma
Published: May 2023

Emergency nurses are prone to burnout due to the nature of their profession and working environment, potentially putting their sustainable employability at risk and so too the care provided by and success of emergency departments. Psychological research has predominantly focused on samples drawn from western, educated, industrialized, rich, and democratic (WEIRD) societies, concerning a small part of the world population. Consequently, this study investigated emergency nurses' burnout in a non-WEIRD society and assessed the role of job demands-resources and work capabilities on their burnout levels. A total of 204 emergency nurses in a South African context participated in a cross-sectional survey. The Job Demands-Resources Scale, the Capability Set for Work Questionnaire, and the Burnout Assessment Tool—Short Form were administered. Using and developing knowledge and skills and building and maintaining meaningful relationships were the strongest work capabilities of emergency nurses. In contrast, earning a good income, involvement in important decisions, and contributing to something valuable were the weakest capabilities. Latent class analysis resulted in three capability sets: a robust capability set, an inadequate capability set, and a weak capability set. Regarding job resources, emergency nurses with a robust capability set reported better relationships with their supervisors and higher job autonomy than the inadequate and weak capability sets. In addition, emergency nurses with a robust capability set reported better co-worker relationships and better access to good equipment than those with a weak capability set. Nurses with an inadequate capability set experienced significantly more challenging job demands than the other two sets. Finally, nurses with a weak capability set (compared to the robust capability set) experienced significantly higher levels of exhaustion and mental distance. Improving emergency nurses' job resources (especially relationships with co-workers and supervisors, job autonomy, and equipment sufficiency) would increase their capabilities, decreasing their burnout levels, especially exhaustion and mental distance.
Daily automated feedback enhances self-regulated learning: a longitudinal randomized field experiment
Authors: Bellhäuser Henrik , Dignath Charlotte , Theobald Maria
Published: May 2023

The goal of the present study was to investigate the effects of automatically generated, adaptive feedback on daily self-regulated learning (SRL) in an experimental field study. University students reported their application of SRL strategies in the morning and in the evening over the course of 36 days using electronic learning diaries. Students were randomly assigned to the experimental group with feedback (LDF, n = 98) or the control group without feedback (LD, n = 96). Based on their self-reports, students in group LDF received daily written feedback regarding their satisfaction with the study day, adherence to time schedule, procrastination, and effort. This feedback either reinforced students in their study approach (confirmative feedback), encompassed information on learning outcomes or processes (informative feedback), or included feed forward on how to improve learning processes (transformative feedback). Multilevel analysis of daily process data revealed better average goal setting, planning and adherence to time schedule, as well as higher self-efficacy, and satisfaction with the study day in group LDF compared to group LD. Motivation, procrastination and effort were not affected by feedback. In contrast to the process measures, pre-post comparisons of students’ self-reported general use of SRL strategies (trait measures) did not reveal any effects of feedback on SRL. Further explorative analyses investigated the effects of confirmative, informative, and transformative feedback on next day’s learning behavior, showing that confirmative and transformative feedback had stronger effects on students’ satisfaction and procrastination than informative feedback. Transformative feedback, which included specific strategies for moving forward, was effective in improving time management. Results provide theoretical insight into the interplay of feedback and SRL and offer practical implications regarding the design of feedback in a learning context.
A direct replication and extension of Popp and Serra (2016, experiment 1): better free recall and worse cued recall of animal names than object names, accounting for semantic similarity
Authors: Mah Eric Y. , Grannon Kelly E. L. , Campbell Alison , Tamburri Nicholas , Jamieson Randall K. , Lindsay D. Stephen
Published: May 2023

Introduction

Free recall tends to be better for names of animate concepts such as animals than for names of inanimate objects. In Popp and Serra’s 2016 article, the authors replicated this “animacy effect” in free recall but when participants studied words in pairs (animate-animate pairs intermixed with inanimate-inanimate pairs) and were tested with cued recall, performance was better for inanimate-inanimate pairs than for animate-animate pairs (“reverse animacy”). We tested the replicability of this surprising effect and one possible explanation for the effect (semantic similarity).

Methods

Our Experiment 1 was a preregistered direct replication (N = 101) of Popp and Serra’s Experiment 1 (mixed-lists condition). In a second preregistered experiment conducted in four different samples (undergraduate N = 153, undergraduate N = 143, online Prolific N = 101, online Prolific/English-as-a-first-language N = 150), we manipulated the within-category semantic similarity of animal and object wordlists.

Results

AIn Experiment 1, just as in Popp and Serra, we observed an animacy effect for free recall and a reverse animacy effect for cued recall. Unlike Popp and Serra, we found that controlling for interference effects rendered the reverse animacy effect non-significant. We took this as evidence that characteristics of the stimulus sets (e.g., category structure, within-category similarity) may play a role in animacy and reverse animacy effects. In Experiment 2, in three out of our four samples, we observed reverse animacy effects when within-category similarity was higher for animals and when within-category similarity was equated for animals and objects.

Discussion

Our results suggest that the reverse animacy effect observed in Popp and Serra’s 2016 article is a robust and replicable effect, but that semantic similarity alone cannot explain the effect.
Bounded rationality, enactive problem solving, and the neuroscience of social interaction
Authors: Viale Riccardo , Gallagher Shaun , Gallese Vittorio
Published: May 2023

This article aims to show that there is an alternative way to explain human action with respect to the bottlenecks of the psychology of decision making. The empirical study of human behaviour from mid-20th century to date has mainly developed by looking at a normative model of decision making. In particular Subjective Expected Utility (SEU) decision making, which stems from the subjective expected utility theory ofSavage (1954)that itself extended the analysis byVon Neumann and Morgenstern (1944). On this view, the cognitive psychology of decision making precisely reflects the conceptual structure of formal decision theory. This article shows that there is an alternative way to understand decision making by recovering Newell and Simon’s account of problem solving, developed in the framework of bounded rationality, and inserting it into the more recent research program of embodied cognition. Herbert Simon emphasized the importance of problem solving and differentiated it from decision making, which he considered a phase downstream of the former. Moreover according to Simon the centre of gravity of the rationality of the action lies in the ability to adapt. And the centre of gravity of adaptation is not so much in the internal environment of the actor as in the pragmatic external environment. The behaviour adapts to external purposes and reveals those characteristics of the system that limit its adaptation. According toSimon (1981), in fact, environmental feedback is the most effective factor in modelling human actions in solving a problem. In addition, his notion ofproblem spacesignifies the possible situations to be searched in order to find that situation which corresponds to the solution. Using the language of embodied cognition, the notion of problem space is about the possible solutions that are enacted in relation to environmental affordances. The correspondence between action and the solution of a problem conceptually bypasses the analytic phase of the decision and limits the role of symbolic representation. In solving any problem, the search for the solution corresponds to acting in ways that involve recursive feedback processes leading up to the final action. From this point of view, the new termenactive problem solvingsummarizes this fusion between bounded and embodied cognition. That problem solving involves bounded cognition means that it is through the problem solver’s enactive interaction with environmental affordances, and especially social affordances that it is possible to construct the processes required for arriving at a solution. Lastly the concept ofenactive problem solvingis also able to explain the mechanisms underlying the adaptive heuristics of rational ecology. Its adaptive function is effective both in practical and motor tasks as well as in abstract and symbolic ones.
Emotion recognition accuracy only weakly predicts empathic accuracy in a standard paradigm and in real life interactions
Authors: Flykt Anders , Dewari Asrin , Fallhagen Martin , Molin Anders , Odda August , Ring Joel , Hess Ursula
Published: May 2023

The relationship between decoding ability (Emotion recognition accuracy, ERA) for negative and positive emotion expressions from only video, only audio and audio-video stimuli and the skill to understand peoples’ unspoken thoughts and feelings (Empathic accuracy, EA) was tested. Participants (N = 101) from three groups (helping professionals with and without therapy training as well as non-helping professionals) saw or heard recordings of narrations of a negative event by four different persons. Based on either audio-video or audio-only recordings, the participants indicated for given time points what they thought the narrator was feeling and thinking while speaking about the event. A Bayesian regression model regressing group and ERA scores on EA scores was showing weak support only for the EA scores for ratings of unspoken feelings from audio only recordings. In a subsample, the quality of self-experienced social interactions in everyday life was assessed with a diary. The analysis of ERA and EA scores in relation to diary scores did not indicate much correspondence. The results are discussed in terms of relations between skills in decoding emotions using different test paradigms and contextual factors.
Sudden bio-mathematical self-similarity and the uniqueness of human mass societies: from T-patterns and T-strings to T-societies
Authors: Magnusson Magnus S.
Published: May 2023

With the explosive growth of human knowledge especially in the twenteeth century with even greater facilitation of access to knowledge, the world of even relatively recent great thinkers becomes daunting as seen from a modern viewpoint. Recently, humans ignored the existence of the complex intracellular world of cell organs, giant information molecules such as DNA, societies of specialized worker molecules (proteins), and generally the surprising nanoscale world visible to humanity since only a few decades ago. Moreover, computational power and video technology were inaccessible to all scientists from, for example, Aristotle to Freud, so new views and ideas seem to be expected about phenomena at all scales including nano and human. Some have arrived very recently. Thus urgently needed knowledge about the biology of animal and human behavior received the first Nobel Prize as late as 1973, in Physiology and Medicine, shared by Karl von Frisch, Konrad Lorenz, and Niko Tinbergen. Lorenz's Nobel lecture was entitled “Analogy as a Source of Knowledge” which did not mention self-analogy (self-similarity) as none of the species studied were part of others and knowledge of the nanoscale phenomena at the heart of this article had barely become available. The views and empirical findings presented in this article depend on such recent intracellular nanoscale insights and the development of a set of mathematical patterns, called T-system, of which only two are considered, the self-similar (i.e., parts having a structure similar to the whole) T-pattern and the derived T-string, a T-patterned material string (here, polymer or text). Specially developed algorithms implemented in the THEMETMsoftware for T-pattern detection and analysis (TPA) allowed the detection of interaction T-patterns in humans, animals, and brain neuronal networks, showing self-similarity between animal interaction patterns and neuronal interaction patterns in their brains. TPA of DNA and text also showed unique self-similarity between modern human literate mass societies and the protein societies of their body cells, both with Giant Extra-Individual Purely Informational T-strings (GEIPIT; genomes or textomes) defining the behavioral potentials of their specialized citizens. This kind of society is here called T-society and only exists in humans and proteins, while the self-similarity between them only exists in human T-societies.
Application of virtual simulation technology in sports decision training: a systematic review
Authors: Yunchao Ma , Mengyao Ren , Xingman Li
Published: May 2023

Introduction

Sports decision-making is a complex process and plays a decisive role in sports performance. Virtual simulation technology is one of the popular sports decision making training tools. The application of virtual reality technology in sports decision making training has received widespread attention. The purpose of this study is to evaluate the scientific evidence of the application of virtual simulation technology in sports decision-making training, and summarize its application advantages and limitations.

Methods

The research literature databases of Web of science, PubMed, SCOPUS and Medline were searched, and the results were screened to determine the application of virtual reality technology in motion decision-making. We identified 10 articles and coded them to record the research design, research object characteristics, VR task setting, experimental intervention and research results.

Results

Through the review, it is found that virtual simulation technology has important value for sports decision-making training. In sports practice, virtual simulation technology can simulate sports decision-making tasks, measure and analyze athletes’ sports decision-making performance. We still need to design a more scientific virtual simulation environment for sports decision-making. In this environment, we can better use virtual simulation technology to improve sports decision-making ability.
Concomitant medications associated with ischemic, hypertensive, and arrhythmic events in MDMA users in FDA adverse event reporting system
Authors: Makunts Tigran , Dahill Diane , Jerome Lisa , de Boer Alberdina , Abagyan Ruben
Published: May 2023

3,4-Methylenedioxymethamphetamine (MDMA) is currently being investigated as an adjunctive treatment to therapy for posttraumatic stress and other anxiety related disorders in clinical trials. Within the next few years MDMA-assisted therapy is projected for approval by regulatory authorities. MDMA’s primary mechanism of action includes modulation of monoamine signaling by increasing release and inhibiting reuptake of serotonin, norepinephrine, and, to a lesser extent, dopamine. This pharmacology affects sympathomimetic physiology. In controlled trials, special attention has been given to cardiovascular adverse events (AEs), because transient increases in heart rate and blood pressure have been observed during the MDMA-assisted therapy sessions. Finding and quantifying the potential drivers of cardiac AEs in clinical trials is difficult since only a relatively small number of participants have been included in these studies, and a limited set of allowed concomitant drugs has been studied. In this study a more diverse set of reports from the FDA Adverse Event Reporting System was surveyed. We found 17 cases of cardiovascular AEs, in which the individuals had taken one or more substances in addition to MDMA. Interestingly, all of those concomitant medications and illicit substances, including opioids, stimulants, anticholinergics, and amphetamines, had been previously associated with cardiovascular AEs. Furthermore, in none of the reports MDMA was marked as the primary suspect.
Impact of modeled field of view in electroconvulsive therapy current flow simulations
Authors: Guillen Alexander , Abbott Christopher C. , Deng Zhi-De , Huang Yu , Pascoal-Faria Paula , Truong Dennis Q. , Datta Abhishek
Published: May 2023

Background

The field of view (FOV) considered in MRI-guided forward models of electroconvulsive therapy (ECT) are, as expected, limited to the MRI volume collected. Therefore, there is variation in model extent considered across simulation efforts. This study examines the impact of FOV on the induced electric field (E-field) due to two common electrode placements: right unilateral (RUL) and bilateral (BL).

Methods

A full-body dataset was obtained and processed for modeling relevant to ECT physics. Multiple extents were derived by truncating from the head down to four levels: upper head (whole-brain), full head, neck, and torso. All relevant stimulation and focality metrics were determined. The differences in the 99th percentile peak of stimulation strength in the brain between each extent to the full-body (reference) model were considered as the relative error (RE). We also determine the FOV beyond which the difference to a full-body model would be negligible.

Results

The 2D and 3D spatial plots revealed anticipated results in line with prior efforts. The RE for BL upper head was ~50% reducing to ~2% for the neck FOV. The RE for RUL upper head was ~5% reducing to subpercentage (0.28%) for the full-head FOV. As shown previously, BL was found to stimulate a larger brain volume—but restricted to the upper head and for amplitude up to ~480 mA. To some extent, RUL stimulated a larger volume. The RUL-induced volume was larger even when considering the neural activation threshold corresponding to brief pulse BL if ECT amplitude was >270 mA. This finding is explained by the BL-induced current loss through the inferior regions as more FOV is considered. Our result is a departure from prior efforts and raises questions about the focality metric as defined and/or inter-individual differences.

Conclusion

Our findings highlight that BL is impacted more than RUL with respect to FOV. It is imperative to collect full-head data at a minimum for any BL simulation and possibly more. Clinical practice resorts to using BL ECT when RUL is unsuccessful. However, the notion that BL is more efficacious on the premise of stimulating more brain volume needs to be revisited.
Effect of widowhood on the risk of disability among the elderly in China
Authors: Pang Jiahui , Xu Shouyi , Wu Yuanyang
Published: May 2023

Background

The deteriorating health status of widowed elderly individuals becomes an important restriction factor affecting healthy aging in China. This paper aimed to find effective ways to reduce the risk of disability among the widowed elderly.

Methods

An empirical analysis was conducted by using four surveys from the China Health and Retirement Longitudinal Study (CHARLS) in 2011, 2013, 2015, and 2018. A fixed-effects model was performed to estimate the effect of widowhood on the disability risk of the elderly in China and its disparities in different groups, and influencing channels and moderating effects were further investigated.

Results

Widowhood significantly increased the risk of disability, and the results were robust. The risk of disability was higher among those who were male, living in urban areas, educated, and 60-to-70-years-old. Possible channels in the association were psychological stress and unhealthy behavior. Meanwhile, more financial support, contact from children, and social activities decreased the risk of disability.

Conclusion

The health risks of older adults after widowhood can be reduced by concerted efforts from society and government, including promoting the traditional Chinese virtue of filial piety and providing health interventions and social support services.
Toxicological effects of micro/nano-plastics on mouse/rat models: a systematic review and meta-analysis
Authors: Liu Weijia , Zhang Bowen , Yao Qianqian , Feng Xihua , Shen Tianling , Guo Peisen , Wang Panpan , Bai Yitong , Li Bo , Wang Peixi , Li Ruiling , Qu Zhi , Liu Nan
Published: May 2023

Micro/nano-plastics (MNPs) are considered a heterogeneous class of environmental contaminants that cause multiple toxic effects on biological species. As the commonly used mammalian models to study the effects of MNPs with regard to their toxic effects, the mouse and rat models are making a great contribution to the disciplines of environmental toxicology and medical health. However, the toxic effects of MNPs have not been systematically summarized. Therefore, a systematic review and a meta-analysis of the toxic effects of MNPs on mouse/rat models were conducted. A total of seven main categories were established in this systematic review, and 24 subcategories were further divided according to the specific physiological significance of the endpoint or the classification of the physiological system, which covered all the selected pieces of literature. A total of 1,762 biological endpoints were found, and 52.78% of them were significantly affected. This fact indicates that there are relative factors, including the size, polymer type, concentration, and exposure time of MNPs and different sexes of mouse/rat models that could significantly affect the biological endpoints. These biological endpoints can be classified into various factors, such as the dose–response relationships between MNP concentration and physiological categories of the nervous system, growth, reproduction, digestive tract histopathology, and inflammatory cytokine level, among others. MNPs negatively affected the blood glucose metabolism, lipid metabolism, and reproductive function in mice. The reproductive function in male mice is more sensitive to the toxic effects of MNPs. These findings also provide insights into and directions for exploring the evidence and mechanisms of the toxic effects of MNPs on human health. It is clear that more research is required on the pathological mechanisms at the molecular level and the long-term effects of tissue accumulation.
Nurses' practices and their influencing factors in palliative care
Authors: Xu Yifan , Zhang Shiwen , Wang Jingrong , Shu Zhiqun , Jing Limei , He Jiangjiang , Liu Mengtian , Chu Tianshu , Teng Xiaohan , Ma Yanan , Li Shuijing
Published: May 2023

Background

In 2017, the Chinese government launched a pilot project in palliative care, in which Shanghai was a pioneer. Nurses play a key role in palliative care services as they are the main providers improving the quality of services for patients and their families. However, little is known about practices and influencing factors in the field of palliative care from a nursing perspective in China. This is an original empirical study that has meticulously analyzed the interrelationship and intensity between practices and other factors among nurses in the initial stage of palliative care in primary healthcare institutions in Shanghai, China.

Methods

A descriptive-correlational study design was used to sample 2,829 eligible palliative care nurses by purposive sampling survey in 225 healthcare institutions in Shanghai, China. Descriptive analyses were performed using IBM SPSS 24.0 software. Structural equation modeling was applied to analyze the data by AMOS 20.0. Data were collected using the well-designed Knowledge, Attitudes, and Practices of Hospice Care (KAPHC) scale.

Results

The final model showed a good model fit. Self-efficacy directly influenced practices (β = 0.506, P < 0.01) and indirectly influenced practices (β = 0.028, P < 0.01) through intention. Subjective norm directly influenced practices (β = 0.082, P < 0.01) and indirectly influenced practices (β = 0.030, P < 0.01) through intention. Intention (β = 0.152, P < 0.01) and knowledge (β = 0.068, P < 0.01) directly influenced practices. Perceived susceptibility (β = −0.027, P < 0.01), perceived benefits (β = −0.017, P < 0.01), and perceived barriers (β = −0.014, P < 0.01) indirectly influenced practices through intention.

Conclusion

This study provided evidence of the associations of knowledge, perceived susceptibility, benefits, barriers, subjective norm, self-efficacy, intention, and practices among nurses concerning palliative care and interventions improving their actual work practices. Our findings revealed that self-efficacy, intention, and subjective norms greatly influenced practices. It is imperative to take interventions that focus precisely on self-efficacy, intention, and subjective norms to improve nurses' practices.
Evidence for “Whole Family Approach” in accelerating uptake of COVID-19 and routine immunizations among integrated primary health services in Nigeria
Authors: Offor Chika , Ade-Banjo Olympus , Nwankwo Chika , Nwaononiwu Grace , Adukwu Faith , Egharevba Bibianna , Owoyemi Joshua , Odo Chibuike , Olatunji Marvellous
Published: May 2023

The family is the simplest unit but possesses the strongest bond in society. These qualities — bond and proximity — that exist both within and across neighboring families, according to our research, can be instrumental in shaping a new kind of health promotion strategy that can transform health behaviors in communities. The Whole Family Approach (WFA) is a government-sanctioned approach to increase uptake of COVID-19 vaccines in Nigeria. The approach entails leveraging the high family-based demand for some primary health services, such as malaria, diabetes, hypertension, and reproductive services, to generate demand for COVID-19 and routine immunizations. However, since the announcement in 2021, there has been no available evidence to show the impact of the approach on COVID-19 vaccine uptake, though global literature generally favors family-centered health approaches. This study tests the effectiveness of the approach in increasing the utilization of target services in a Nigerian community and further provides a theoretical framework for the strategy. Two primary healthcare facilities were selected in two communities located in Abuja in a quasi-experimental design. After a small-sample landscape assessment of the communities and the facilities, family-targeting health promotion activities were facilitated in the intervention community (integrated health education by trained community health influencers) and facility (opportunistic health promotion through in-facility referrals) for one month. Anonymized service utilization data were acquired from both facilities over a period of four months to analyze their respective month-by-month service utilization trends. Time trend analysis was conducted and revealed that WFA significantly increased service utilization (N = 5870; p < 0.001, α = 0.01, 99% CI) across all the package services provided at the intervention facility. A supplementary Pearson's correlation analysis further presented a positive relationship (r = 0.432–0.996) among the services which favored the result. It can therefore be concluded that the “Whole Family Approach” of health promotion is efficacious in accelerating uptake of priority health services such as COVID-19 and routine immunizations. While there is more to be understood about this interesting approach, we recommend the improvement of communication and capacity gaps in Nigeria's primary healthcare system to ensure that promising strategies such as the WFA are adequately implemented at the community and facility levels.
Interactive and incremental learning of spatial object relations from human demonstrations
Authors: Kartmann Rainer , Asfour Tamim
Published: May 2023

Humans use semantic concepts such as spatial relations between objects to describe scenes and communicate tasks such as “Put the tea to the right of the cup” or “Move the plate between the fork and the spoon.” Just as children, assistive robots must be able to learn the sub-symbolic meaning of such concepts from human demonstrations and instructions. We address the problem of incrementally learning geometric models of spatial relations from few demonstrations collected online during interaction with a human. Such models enable a robot to manipulate objects in order to fulfill desired spatial relations specified by verbal instructions. At the start, we assume the robot has no geometric model of spatial relations. Given a task as above, the robot requests the user to demonstrate the task once in order to create a model from a single demonstration, leveraging cylindrical probability distribution as generative representation of spatial relations. We show how this model can be updated incrementally with each new demonstration without access to past examples in a sample-efficient way using incremental maximum likelihood estimation, and demonstrate the approach on a real humanoid robot.
Digital ethnography: ethics through the case of QAnon
Authors: Cera Michelle
Published: May 2023

Introduction

Digital ethnography is a relatively new practice with unclear standards and guidelines. As a result, the ethics of the practice remain unclear. Scholarly debates have emerged surrounding the decision of many researchers and institutional review boards to treat social media data as public. Concerns have also been raised about how informed consent can be adapted to online fieldwork. How does a researcher make their presence known when they are not visible in the traditional sense? Which online interactions should be considered public, and which are private? How can we protect the anonymity of social media users?

Methods

This article leverages original digital ethnographic research on QAnon social media spaces to suggest ethical guidelines for digital ethnographic practices.

Discussion

It begins with a description of the research, followed by discussions of the public-private binary, lurking, data reconstruction, and institutional review boards.

Results

This article advocates for rethinking the public-private binary as it applies to the digital world, ameliorating the “lurker” concern by making the presence of the researcher known in appropriate spaces, and maintaining the integrity of the data by avoiding reconstruction. Although many digital ethnographers have chosen to reconstruct or paraphrase online data to protect privacy, this practice comes with its own ethical dilemmas. The ethical dilemmas and guidance discussed in this article are critical lessons for digital and in-person ethnographers alike.
Exploring Venus: next generation missions beyond those currently planned
Authors: Limaye Sanjay S. , Garvin James B.
Published: May 2023

As of mid-2023 at least ten missions are in development or being planned to explore Venus in the next 2 decades. Most of these emphasize atmospheric chemistry and surface/interior scientific objectives and only a few directly address past and present habitability of Venus as a primary science goal. All of the missions employ previously flight-tested platforms—Orbiters and general atmospheric probes, yet none (as of yet) plan to utilize longer-lived atmospheric platforms (e.g., balloons or airships) or landers. Thus several key questions about Venus will necessarily remain unanswered after the current wave of missions in development which will explore Venus starting in 2029 and continuing throughout the 2030s. This future-oriented perspective outlines the major scientific questions that the next-generation of missions to Venus should address for a better understanding of the planet as a system and provide a reliable comparative basis for the Venus-analogue exoplanets which can be investigated only by means of remote observations such as from the James Webb Space Telescope (JWST). This next generation of Venus missions may require long lived atmospheric platforms that either float or which “fly” at different altitudes, longer lived surface stations, and eventually samples of the atmosphere/cloud particles (aerosols) and surface returned to Earth laboratories. Although ideas for aerial platforms, long-lived landers, and missions to return atmospheric and surface samples are being conceptualized at present to be ready for upcoming international competed opportunities (e.g., NASA, ESA, ISRO, JAXA), they await further investment in technologies to provide the combination of scientific measurement capabilities and flight-system performance to make the breakthroughs that the community will expect, guided by longstanding science priorities.