bluuebunny/crossref_metadata_2025 huggingface dataset:
Polymicrobial native valve endocarditis due toBacillus cereusandCardiobacterium hominis
Authors: Meledathu Sherin , Denyer Rachel , Roberts Afsoon , Simon Gary
Published: December 2021

We present a case of polymicrobial subacute bacterial endocarditis and bacteremia withBacillus cereusandCardiobacterium hominisin a 72-year-old man with pre-existing mitral valve disease and prior mitral valve repair who presented with renal failure and glomerulonephritis.Bacillusis often a contaminant in blood cultures but has been rarely implicated in patients with invasive infections such as endocarditis. Intravenous drug use, prosthetic heart valves, valvular heart disease and venous catheters are the most frequently described risk factors forBacillusbacteremia and endocarditis in the medical literature. Management is challenging asBacillusis resistant to penicillin and cephalosporin antibiotics due to production of beta-lactamase. Polymicrobial endocarditis is uncommon and when it occurs typically involvesStaphylococcalspecies. To our knowledge, this is the first reported case of polymicrobial endocarditis in which bothBacillusand a HACEK organism are implicated.
The Improving Global Health Programme - leadership development in the NHS through overseas placement
Authors: Streeton Ann-Marie , Kitsell Fleur , Kung Munichan , Oo Myint , Rowse Vicki , Wadd Viki , Shere Harriet
Published: December 2021

The Improving Global Health (IGH) programme develops leadership capacity within the National Health Service (NHS) in a novel way. NHS employees collaboratively run quality improvement projects within organisations in low-income and middle-income countries with whom long-standing healthcare partnerships have been built. Leadership behaviours are developed through theoretical and experiential learning, alongside induction and mentorship. The health systems of overseas partners are strengthened through projects that align with local priorities. This article develops solutions to two main problems: how reciprocal global health programmes can be designed and how global health programmes based in leadership can attract women and black and minority ethnic groups into leadership. The outcomes of both sides of the IGH programme are described here. The overseas perspective is described using the reflections of two current partners, highlighting improvements in the local healthcare system and demonstrating growth in local team members. The UK perspective is evaluated using two surveys sent to different groups of returned IGH participants. Leadership, global health and quality improvement skills improve, having a significant and long-lasting impact on career trajectory. The IGH programme is attracting women and black and minority ethnic groups into leadership. Through collaboration and reciprocity, the IGH programme is developing a new cadre of NHS leader that is diverse and inclusive. The use of long-standing healthcare partnerships ensures that learning is shared and growth is mutual, creating development within the overseas and UK partner alike.
Switch receptor T3/28 improves long-term persistence and antitumor efficacy of CAR-T cells
Authors: Zhao Songbo , Wang Chunhua , Lu Ping , Lou Yalin , Liu Huimin , Wang Ting , Yang Shanshan , Bao Ziyou , Han Lin , Liang Xiaohong , Ma Chunhong , Gao Lifen
Published: December 2021

Background

Chimeric antigen receptor (CAR) T cells have been successfully used in tumor immunotherapy due to their strong antitumor responses, especially in hematological malignancies such as B cell acute lymphoid leukemia. However, on-target off-tumor toxicity and poor persistence severely limit the clinical application of CAR-T cell therapy.

Methods

T-cell immunoglobulin mucin domain molecule 3 (TIM-3) was used to develop a second-generation 41BB CD19 CAR linked with a T3/28 chimera, in which truncated extracellular TIM-3 was fused with the CD28 transmembrane and cytoplasmic domains. The efficacy of T3/28 CAR-T cells was evaluated in vitro and in vivo.

Results

We demonstrated that the switch receptor T3/28 preserved the TCMphenotype, improved proliferative capacity, and reduced exhaustion of CAR-T cells, resulting in superior in vitro and in vivo antitumor activity in B lymphoma. Importantly, the switch receptor T3/28 substantially prolonged the persistence of CAR-T cells, and the interleukin-21/Stat3 axis probably contributed to the enhanced cytotoxicity of T3/28 CAR-T cells.

Conclusion

Overall, the T3/28 chimera significantly prolonged the persistence of CAR-T cells, and T3/28 CAR-T cells possessed potent antitumor activity in mice, shedding new light on potential improvements in adoptive T cell therapies.
Comparison of contralateral oblique view with the lateral view for fluoroscopic-guided cervical epidural steroid injection: a randomized clinical trial
Authors: Sim Ji-Hoon , Kwon Hyun-Jung , Kim Chan-Sik , Kim Eun Ha , Kim Doo-Hwan , Choi Seong-Soo , Shin Jin-Woo
Published: December 2021

Background

Cervical epidural steroid injection is associated with rare but potentially catastrophic complications. The contralateral oblique (CLO) view may be a safe and feasible alternative to the lateral (LAT) view for fluoroscopic-guided cervical epidural steroid injection. However, evidence for the clinical usefulness of the CLO view for cervical epidural steroid injection is lacking. We assessed the clinical usefulness of the CLO view for cervical epidural steroid injection in managing cervical herniated intervertebral discs.

Methods

Patients were randomly assigned to receive fluoroscopic-guided cervical epidural steroid injection under LAT view or CLO view at 50±5° degrees groups. The primary outcome was the needling time comparison between the two groups. Secondary outcomes were comparison of first-attempt success rate, needle tip visualization and location, total number of needle passes, final success rate, crossover success rate and false-positive/negative loss of resistance. Complications and radiation dose were also compared.

Results

The needling time significantly decreased in the CLO than in the LAT group. The first-attempt success rate was significantly higher in the CLO compared with the LAT group. The needle tip was clearly visualized (p<0.001) and located more often on (or just anterior to) the ventral interlaminar line (p<0.001) in the CLO than in the LAT group. There were significantly fewer needle passes (p=0.019) in the CLO than in the LAT group. There were no significant differences in the final success, crossover success, false-positive/negative loss of resistance or radiation dose between the groups. Two (5.9%) cases in the LAT group experienced complications.

Conclusion

The CLO view may be recommended for fluoroscopic-guided cervical epidural steroid injection, considering its better clinical usefulness over the LAT view.
Betaine formation from the reactions of N-heterocyclic carbenes with polarized alkenes
Authors: Ghanbari Hamed , Robertson Katherine N. , Clyburne Jason A.C. , Soleimani Ebrahim
Published: December 2021

N-Heterocyclic carbenes [1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene 1a (IMes) or 1,3-bis(2,6-di-iso-propylphenyl)imidazolidene 1b (SIPr)] react with the polarized alkenes 2 and 4 to form the crystalline betaines 3a, 3b, and 5a. Furthermore, a one-pot reaction between an aldehyde, malononitrile, and an imidazolium salt of an N-heterocyclic carbene has been developed for the efficient preparation of betaine 5a without isolation of the free carbene. Full characterization data, including X-ray crystal structures, is reported for the three synthesized betaines. The structures of the betaines 3a, 3b, and 5a shed new light on the initial products formed in the reactions between N-heterocyclic carbenes and compounds containing polarized double bonds.
Preparation of Novel ZnO/Cu2O Heterojunctions Composite Film by Codeposition Method and Their Enhanced Photocatalytic Performance Analysis
Authors: Yu Xiaojiao , Ji Qinggong , Wei Yuchen , Liu Zongbin , Zhao Ningning , Yang Meng , Yang Qian
Published: December 2021

Refractory organic pollutants have caused widespread concern about their pollution of water environments. Photocatalytic oxidation technology is an effective way to remove organic pollutants. Photocatalyst is the components core of photocatalytic oxidation technology. The development of visible light responsive catalysts with high catalytic activity is of great significance for the removal of organic pollutants using sunlight as a light source. In this paper, a codeposition method is used to prepare ZnO/Cu2O composite film with a heterojunction structure in one step. The microstructure and photoelectric properties of the prepared ZnO/Cu2O composite film are characterized and analyzed, and its photocatalytic performance is evaluated. Compared with pure the Cu2O film, the composite film exposes more (111) crystal planes, and has a smaller impedance and a larger photocurrent and open circuit voltage value. These findings indicate that the ZnO/Cu2O composite film exhibits excellent photogenerated carrier separation and migration efficiencies. Among the prepared samples, M2 demonstrates the highest photocatalytic and recycling performance. The calculation of the band position shows that the Fermi level of the composite film exhibits a significant shift compared to that of the pure Cu2O film. The analysis shows that the decrease in the recombination probability of photogenerated carriers caused by the shift of the Fermi level and formation of an internal electric field is the main factor for the significant enhancement in the Cu2O photocatalytic performance. This article provides a novel method and idea to realize the efficient removal of organic dye pollutants in sewage.
Thiophene Functionalized Porphyrin for Electrochemical Carbon Dioxide Reduction
Authors: Kaplan Ekrem , Gümrükçü Selin , Gençten Metin , Şahin Yücel , Hamuryudan Esin
Published: December 2021

The production of catalysts that display strong efficiencies in aqueous media for the electrochemical carbon dioxide reduction reaction (CO2RR) is essential both for a healthy world and for realistic application of energy waste to generate value-added fuels. In this study, thiophene functionalized metal-free (poly-H2Por) and cobalt porphyrin-based (poly-CoPor) organometallic catalysts were easily attached on the pencil graphite electrode surface via electrochemical polymerization method and these, porphyrin coated, pencil graphite electrodes (PGE) were used as electrocatalysts for electrochemical CO2 reduction for the first time in the literature. To reveal the electrochemical activity of CO2RR, the electropolymerized catalysts were investigated with linear sweep voltammetry in 0.1 M KHCO3 solution. The results showed that, the electrode which is modified with poly-CoPor decreased the overpotential of CO2RR, according to bare pencil graphite electrode, from −1.35 V to −0.63 V.
Quantitative Characterization for the Micronanopore Structures of Terrestrial Shales with Different Lithofacies Types: A Case Study of the Jurassic Lianggaoshan Formation in the Southeastern Sichuan Basin of the Yangtze Region
Authors: Liu Weiwei , Zhang Kun , Li Qianwen , Yu Zhanhai , Cheng Sihong , Liu Jiayi , Liu Pei , Han Fengli , Tang Liangyi , Li Zhengwei , Yuan Xuejiao , Yang Yiming , Zeng Yao , Zhang Chen
Published: December 2021

Due to the specificity of the geological background, terrestrial strata are widely distributed in the major hydrocarbon-bearing basins in China. In addition, terrestrial shales are generally featured with high thickness, multiple layers, high TOC content, ideal organic matter types, and moderate thermal evolution, laying a solid material foundation for hydrocarbon generation. However, the quantitative characterization study on their pore structure remains inadequate. In this study, core samples were selected from the Middle Jurassic Lianggaoshan Formation in the southeastern Sichuan Basin of the Upper Yangtze Region for analyses on its TOC content and mineral composition. Besides, experiments including oil washing, the adsorption/desorption of CO2 and nitrogen, and high-pressure mercury pressure experiments were carried out. The pore structure of different petrographic types of terrestrial shales can be accurately and quantitatively characterized with these works. The following conclusions were drawn: for organic-rich mixed shales and organic-rich clay shales, the TOC content is the highest; the pore volume, which is primarily provided by macropores and specific surface area, which is provided by mesopores, was the largest, thus providing more space for shale oil and gas reservation. The pores take on a shape either close to a parallel plate slit or close to or of an ink bottle. For organic-matter-bearing shales, both the pore volume and specific surface area are the second-largest and are provided by the same sized pores with organic-rich mixed shales. Its pores take on a shape approximating either a parallel plate slit or an ink bottle. Organic-matter-bearing mixed shales have the lowest pore volume and specific surface area; its pore volume is primarily provided by macropores, and the specific surface area by mesopores and the shape of the pores are close to an ink bottle.
Mediastinal Extension of a Pancreatic Pseudocyst: A Rare Intrathoracic Complication of Pancreatitis
Authors: Vitellas Carol , Mangeb Ivo Besong , Regalado Luis , Amadi Chiemezie Chianotu
Published: December 2021

Pancreatic pseudocysts are a common complication of pancreatitis. However, mediastinal extension of a pseudocyst is rare and often presents with atypical symptoms. We present a case of mediastinal extension of a pancreatic pseudocyst in a 56-year-old woman with a history of alcohol-related chronic pancreatitis, who presented with acute on chronic epigastric abdominal pain and atypical chest pain. Serum lipase was elevated, and imaging by contrast-enhanced computed tomography (CT) demonstrated a paraesophageal fluid collection. This collection was continuous with a peripancreatic pseudocyst and extended into the posterior mediastinum via the esophageal hiatus. Mediastinal extension of a pancreatic pseudocyst was confirmed by magnetic resonance imaging (MRI). The patient was managed conservatively in the hospital with parenteral nutrition therapy, pain control, and close imaging observation. The patient was discharged home to continue conservative management and close imaging follow-up. An initial follow-up CT examination 8 weeks after discharge revealed interval decrease in the posterior mediastinal collection but also interval development of loculated left pleural and pericardial effusions.
The Prediction of Atherosclerosis Index Based on Photoplethysmograph
Authors: Li Yibing , Xie Fei , Ren Xiaoye , Cao Fenyun
Published: December 2021

Current atherosclerosis (AS) assessment devices have a disadvantage for users to carry around. In response to this shortcoming, we propose to collect the wrist photoplethysmograph (PPG) signal and create models to predict the indicators of atherosclerosis (cardiovascular age and right brachial and ankle pulse wave velocity (baPWV)). This study uses the maximum correlation coefficient method for feature selection and establishes multiple models to predict cardiovascular age and the right baPWV. The study results show that the prediction of cardiovascular age using the backpropagation (BP) neural network model is the best. Its Pearson correlation coefficient (PCC) is 0.9501 (

P
<
0.05

), and the model finds the best six physiological features as crest time (CT), crest time ratio (CTR), slop K, stiffness index (SI), reflection index (RI), and heart rate (HR). When predicting the right baPWV value on the right side, we propose a hybrid method MLR_BP, which has better experimental results than BP and MLR. The MLR_BP model improves the prediction accuracy, the predicted PCC value is 0.9204 (

P
<
0.05

), and the model only needs two features, HR and cardiovascular age. This study further verified the results of related literature and proved the relationship between AS and related physiological parameters. The proposed method is applied to wearable devices and has an application value for diagnosing AS and preventing cardiovascular diseases.
Performance Prediction of the Ferrous Metal Smelting and Rolling Processing Industry in Supply-Side Structural Reform in China
Authors: Shi Kaihe , Du Danning , Zhang Xiaoxuan
Published: December 2021

Supply-side structural reforms and environmental protection policies have a great impact on the ferrous metal smelting and rolling processing industry. This paper uses a grey model that introduces a fractional-order cumulative generating operator to study the development of ferrous metal smelting and rolling processing enterprises under the influence of supply-side structural reform in order to derive the future development trend of the industry. The forecast results show that from 2018 to 2022, the number of enterprises and substitute enterprises, inventory, finished products, and assets and liabilities decreases; the scale of income of metal smelting and rolling processing industry increases. The results can serve as a reference for policy makers and industry investors.
Regulatory Mechanism of LINC00152 on Aggravating Heart Failure through Triggering Fibrosis in an Infarcted Myocardium
Authors: Song Lizhong , Duan Xiujuan , Zeng Xiaojuan , Duan Xinglian , Li Li
Published: December 2021

Objective. To elucidate the role of LINC00152 in the progression of heart failure following myocardial infarction. Patients and Methods. Serum levels of LINC00152 in acute myocardial infarction (AMI) patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). Receiver operating characteristic (ROC) curves were depicted for assessing the diagnostic value of LINC00152 in AMI. Subsequently, an in vivo AMI model was generated in mice. LINC00152 level in a mouse infarcted myocardium was detected. Echocardiogram was conducted to evaluate the influence of LINC00152 on cardiac function in AMI mice. Primary cardiac fibroblasts were isolated from neonatal mice. After knockdown of LINC00152, proliferative and migratory changes in primary cardiac fibroblasts were assessed by cell counting kit-8 (CCK-8) and transwell assay, respectively. The regulatory effect of LINC00152 on Smad7 level was determined by qRT-PCR. Finally, the involvement of Smad7 in LINC00152-regulated proliferative and migratory abilities in primary cardiac fibroblasts was explored by rescue experiments. Results. Serum level of LINC00152 was elevated in AMI patients. ROC curves demonstrated the diagnostic potential of LINC00152 in AMI (95% CI: 0.806-0.940,

p
=
0.034

). In myocardial tissues collected from AMI mice, LINC00152 level was higher than those collected from mice of the sham group. LVEF and FS markedly decreased in AMI mice overexpressing LINC00152 on the 4th week of AMI modeling. After knockdown of LINC00152 in primary cardiac fibroblasts, proliferative and migratory abilities were declined, which were abolished by Smad7 intervention. Conclusions. By downregulating Smad7, LINC00152 aggravates heart failure following AMI via promoting the proliferative and migratory abilities in cardiac fibroblasts.
Hygroscopic Properties of Sweet Cherry Powder: Thermodynamic Properties and Microstructural Changes
Authors: Ouaabou Rachida , Ennahli Said , Di Lorenzo Chira , Hanine Hafida , Bajoub Aadil , Lahlali Rachid , Idlimam Ali , Ait Oubahou Ahmed , Mesnaoui Mohamed
Published: December 2021

Understanding sorption isotherms is crucial in food science for optimizing the drying processes, enhancing the shelf-life of food, and maintaining food quality during storage. This study investigated the isotherms of sweet cherry powder (SCP) using the static gravimetric method. The experimental water sorption curves of lyophilized sweet cherry powder were determined at 30°C, 40°C, and 50°C. The curves were then fitted to six isotherm models: Modified GAB, Halsey, Smith, Oswin, Caurie, and Kühn models. To define the energy associated with the sorption process, the isosteric sorption heat, differential entropy, and spreading pressure were derived from the isotherms. Among the six models, the Smith model is the most reliable in predicting the sorption of the cherry powder with a determination coefficient (R2) of 0.9978 and a mean relative error (MRE) ≤1.61. The values of the net isosteric heat and differential entropy for the cherry increased exponentially as the moisture content decreased. The net isosteric heat values varied from 10.63 to 90.97 kJ mol−1, while the differential entropy values varied from 27.94 to 273.39 J. mol−1K−1. Overall, the enthalpy-entropy compensation theory showed that enthalpy-controlled mechanisms could be used to regulate water adsorption in cherry powders.
Exponentially Fitted Element-Free Galerkin Approach for Nonlinear Singularly Perturbed Problems
Authors: Kaur Jagbir , Sangwan Vivek
Published: December 2021

As it is well recognized that conventional numerical schemes are inefficient in approximating the solutions of the singularly perturbed problems (SPP) in the boundary layer region, in the present work, an effort has been made to propose a robust and efficient numerical approach known as element-free Galerkin (EFG) technique to capture these solutions with a high precision of accuracy. Since a lot of weight functions exist in the literature which plays a crucial role in the moving least square (MLS) approximations for generating the shape functions and hence affect the accuracy of the numerical solution, in the present work, due emphasis has been given to propose a robust weight function for the element-free Galerkin scheme for SPP. The key feature of nonrequirement of elements or node connectivity of the EFG method has also been utilized by proposing a way to generate nonuniformly distributed nodes. In order to verify the computational consistency and robustness of the proposed scheme, a variety of linear and nonlinear numerical examples have been considered and

L

∞

errors have been presented. Comparison of the EFG solutions with those available in the literature depicts the superiority of the proposed scheme.
Antiphospholipid Syndrome Associated with Nonradiographic Axial Spondyloarthritis
Authors: De Carvalho Jozélio Freire , Fernanda Mendanha Sousa Antoniella
Published: December 2021

Herein, we describe a patient with antiphospholipid syndrome (APS) associated with nonradiographic axial spondyloarthritis (NRAS). A 31-year-old woman with a past medical history of uveitis experienced a pulmonary thromboembolism in March 2014 and was treated with rivaroxaban (20 mg/day). Five months later, she started complaining of low back pain. The results on contrast-enhanced sacroiliac magnetic resonance imaging were normal. Laboratory tests revealed positive HLA-B27 and the presence of lupus anticoagulant and IgM anticardiolipin. The diagnoses of APS and NRAS were made. The patient was treated with rivaroxaban for APS and sulfasalazine (2 g/day), respectively. As she showed the presence of lupus anticoagulant antibodies in blood, she did not receive nonsteroidal anti-inflammatory drugs. After 6 months, the patient was asymptomatic, without lumbar pain; she also showed normalization of the erythrocyte sedimentation rate and the C-reactive protein and vitamin D levels, good control of lumbar pain, and no new uveitis episodes. The APS was also stable. To the best of our knowledge, this is the first reported case of NRAS associated with APS.
Intelligent Noise Reduction Algorithm to Evaluate the Correlation between Human Fat Deposits and Uterine Fibroids under Ultrasound Imaging
Authors: Luo Yan , Huang Wenxia , Zeng Kewei , Zhang Chunfeng , Yu Chunyan , Wu Wencui
Published: December 2021

This study aimed to realize the automatic diagnosis of fatty degeneration of uterine fibroids. In this study, the traditional nonlocal means (NLM) algorithm was improved by changing the Euclidean distance and introducing a cosine function and applied to the ultrasonic imaging intelligent diagnosis of patients with fatty degeneration of uterine fibroids. Then, the noise reduction effect of the improved NLM algorithm was evaluated based on several indicators, such as peak signal-to-noise ratio (PSNR), mean square error (MSE), contrast-to-noise ratio (CNR), figure of merit (FOM), and structural similarity (SSIM). The accuracy, sensitivity, specificity, and F1 score were adopted to evaluate the improved NLM algorithm for diagnosing fatty degeneration of uterine fibroids, and the Perona–Malik (PM) algorithm and NLM algorithm were used for comparative analysis. The results showed that after the ultrasound images of patients with uterine fibroids were denoised using the improved NLM algorithm, the PSNR, MSE, CNR, FOM, and SSIM were obviously better than the same indicators of the image processed with the PM algorithm and the NLM algorithm, and the differences were statistically significant (

P
<
0.05

). The diagnosis results of patients with fatty degeneration of uterine fibroids found that there was only one patient with missed diagnosis after the ultrasound image was processed with NLM algorithm, and there was no statistical difference between the improved NLM algorithm and the assisted diagnosis accuracy of the pathological examination results (

P
>
0.05

). The average noise reduction time of the PM algorithm, NLM algorithm, and the improved NLM algorithm was 16.38 ± 4.33 s, 18.01 ± 5.14 s, and 23.81 ± 4.62 s, respectively. The diagnosis rate before improvement was 75.0%, the diagnosis accuracy rate for PM was 79.69%, and that after improvement was 85.94%. In summary, the improved NLM algorithm showed a good noise reduction effect on ultrasound images of patients with uterine fibroids, could improve the diagnosis accuracy of fatty degeneration of uterine fibroids, and could assist clinicians in the ultrasound imaging diagnosis of patients with uterine fibroids.
Research on Optimization Path of Intelligent Pension Industry Based on Intelligent Fusion Algorithm of Multisource Information
Authors: Hao Gang , Sun Qing , Han Ping
Published: December 2021

Accurate quantitative evaluation of the supervision effect of the smart pension industry can reduce the cost of social pension. The traditional methods cannot effectively classify the regulatory risk levels of the smart pension industry. Therefore, this paper proposes a multisource information intelligent fusion algorithm based on the intelligent pension industry optimization path research. Firstly, we establish the principal model of the supervision effect system of the intelligent elderly care industry optimization path and describe the risk level of the supervision effect from different levels. We build the intelligent service platform of the intelligent elderly care training, calculate the weight vector of the supervision risk of the optimization path at all levels, and determine the attribute type of the supervision effect at all levels. Finally, we calculate the maximum influence value of the supervision effect of the intelligent elderly care industry optimization path and use this value to complete the quantitative evaluation of its supervision effect. Simulation results show that the proposed method can evaluate the regulatory effect of smart pension industry and improve the precision of the regulatory effect of smart pension industry effectively.
An English Teaching Ability Evaluation Algorithm Based on Frequency Effect
Authors: Xu Lan
Published: December 2021

Background. English is one of the courses offered in all colleges and universities. The quality of English teaching is directly related to the quality of talent training and the development of students themselves. “Teaching quality evaluation” specifically refers to the education evaluation with teaching as the evaluation object. It is the core and foundation of the whole education evaluation. Teaching quality evaluation is based on certain teaching objectives and teaching norms and standards, through the systematic detection and assessment of teaching and learning. Evaluate its teaching effect and the degree of realization of teaching objectives, and use scientific and feasible methods to make corresponding value judgments to improve the process of teaching. To improve the accuracy of English teaching ability evaluation, an English teaching ability evaluation algorithm based on frequency effect is proposed. Methods. The paper proposes an English teaching ability evaluation algorithm based on frequency effect. Firstly, it constructs the evaluation index system of English teaching ability, including expert evaluation system, student evaluation system, and teacher evaluation system. Then, the indexes affecting the evaluation of English teaching ability are quantified by fuzzy synthesis, and the evaluation indexes are refined. Finally, the basic principle of frequency effect is analyzed, combined with the convolutional neural network. Results. The convolutional neural network evaluation model is constructed, the teaching ability indicators are input into the model, the final evaluation results are output, and the design of the English teaching ability evaluation algorithm based on frequency effect is completed. Conclusions. The experimental results show that this method has high accuracy and efficiency.
Protective Effect of Fasudil on Hydrogen Peroxide-Induced Oxidative Stress Injury of H9C2 Cardiomyocytes
Authors: Zhang Yu , Liu Shanxin , Li Xiaochun , Ye Jian
Published: December 2021

Objective. Oxidative damage is a pathological factor that causes cardiovascular damage in the clinic and is increasingly serious. This study focused on the effect of fasudil on H2O2-induced oxidative damage in cardiomyocytes. Materials and Methods. H9C2 cardiomyocytes were cultured in vitro and divided into three groups: control group (Con group), H2O2 treatment (H2O2 group), and fasudil and H2O2 cotreatment (H2O2+fasudil group). The content levels of LDH and MDA in the supernatant were detected, and the morphology of H9C2 cardiomyocytes was observed by light microscopy. 8-OHdG staining was observed by a fluorescence inversion microscope. Cell Counting Kit (CCK-8), western blotting, real-time polymerase chain reaction (RT-PCR), and enzyme-linked immunosorbent assay (ELISA) were used to investigate the effect of fasudil on the Rho/ROCK signaling pathway. Results. Our results showed that after H2O2 treatment, the H9C2 cardiomyocytes were irregular in shape and elliptical. But the morphology of the H2O2+fasudil group was similar to that of the Con group. The green fluorescence of the H2O2 group was significantly enhancer than that of the Con group, while the green fluorescence of the H2O2+fasudil group was weaker than those of the H2O2 group. By detecting the supernatant, it was found that the contents of LDH were significantly increased, and the contents of SOD and CAT in the H2O2 group were significantly decreased. And the expression of antioxidant indicators in the H2O2 group was significantly decreased by western blotting. The results of RT-PCR showed that SOD1 and SOD2 mRNA in the H2O2 group was significantly reduced, and the contents of GPX1 and GPX3 in the H2O2 group were significantly decreased by enzyme-linked immunosorbent assay (ELISA). The expression of ROCK1, ROCK2, and downstream phosphorylation of myosin phosphatase target subunit-1 (p-MYPT-1) was significantly increased in the H2O2 group, while fasudil inhibited the increase of ROCK1, ROCK2, and p-MYPT-1. Conclusions. Fasudil can inhibit the Rho/ROCK signaling pathway induced by H2O2 and reduce oxidative stress response, inhibit apoptosis, and improve antioxidant enzyme activity in H9C2 cardiomyocytes thereby delaying cell senescence.
Care of Maintenance Hemodialysis Patients through Intelligent Algorithm-Based Low-Dose Digital Subtraction Angiography
Authors: Hong Jianhua
Published: December 2021

Objective. The study aimed to explore the application value of artificial intelligence (AI)-based low-dose digital subtraction angiography (DSA) in the care of maintenance hemodialysis (MHD) patients. Methods. The characteristics of DSA imaging were analyzed, and the refinement efficiency of the AI algorithm was discussed, expected to assist clinicians in the care and treatment of patients. 100 MHD patients who were in the hospital were selected as the research subjects. They were randomly divided into the conventional DSA group (conventional group) and the AI algorithm-based DSA group (AI-based DSA group). The conventional group used conventional DSA images to guide the care of HM patients, and the AI-based DSA group used the AI algorithm to optimize DSA images. Results. It was found that the AI-based DSA group was better than the conventional DSA group in terms of image sharpness and shaded areas, and the image mean square error (MSE) loss value was smaller (

P
<
0.05

). The patients were followed up for 3 months. In the AI-based DAS group, the blood flow of the drainage vein (DV), the blood flow of the proximal vein (PA), and the blood flow of the brachial artery (BA) were greater than those of the conventional group (

P
<
0.05

). During the 3-month follow-up period, in the conventional group, thrombosis occurred in 4 patients, low-flow AVF occurred in 5 patients, high-flow AVF occurred in 3 patients, and heart failure occurred in 5 patients. In the AI-based DSA group, thrombosis occurred in 2 patients, low-flow AVF occurred in 2 cases, high-flow AVF occurred in 1 case, and heart failure occurred in 3 cases. There were no other cardiac complications in both groups. Conclusion. DSA images optimized by the AI algorithm are suitable for clinical diagnosis and have practical application value.
Effectiveness of Insole Colour on Impact Loading and Lower-Limb Kinematics When Running at Preferred and Nonpreferred Speeds
Authors: Wang Yi , Lam Wing-Kai , Pak Lok-Yee , Wong Charis K.-W. , Tan Mohammad F. , Leung Aaron K.-L.
Published: December 2021

While colour of red can play a significant role in altering human perception and performances, little is known about its perceptual-motor effect on running mechanics. This study examined the effects of variations in insole colours on impact forces, ankle kinematics, and trial-to-trial reliability at various running speeds. Sixteen male recreational runners ran on instrumented treadmill at slow (90%), preferred (100%), and fast (110%) running speeds when wearing insoles in red, blue, and white colours. We used synchronized force platform and motion capturing system to measure ground reaction force, ankle sagittal and frontal kinematics, and movement variability. A two-way (colour x speed) ANOVA with repeated measures was performed with Bonferroni adjusted post hoc comparisons, with alpha set at 0.05. Data analyses indicated that participants demonstrated higher impact and maximum loading rate of ground reaction force, longer stride length, shorter contact time, and smaller touchdown ankle inversion as well as larger ankle sagittal range of motion (RoM), but smaller frontal RoM in fast speed as compared with preferred

P
<
0.05

and slow speeds

P
<
0.001

. Although insole colour had minimal effect on mean values of any tested variables

P
>
0.05

, participants wearing red-coloured orthoses showed higher coefficient of variation values for maximum loading rate than wearing blue insoles

P

=

0.009

. These results suggest that running at faster speed would lead to higher impact loading and altered lower-limb mechanics and that colour used on the tops of insoles influences the wearers’ movement repeatability, with implications for use of foot insole in running.
Preliminary Research on a High Thrust-to-Weight Ratio of Double-Sided Composite Impeller Microturbine Engine
Authors: Zhang Cheng , Yang Bei , Wang Yun , Tu Gaoxing
Published: December 2021

In some situations, the improvement of the thrust-to-weight ratio (TWR) of microturbine engines (MTEs) for energy-, economic-, and environment-related reasons can be achieved for military or civilian purposes. However, due to limitations of existing traditional MTE technology, it is difficult to meet the key requirements of small aircraft for high energy/power density and low-cost power, especially for long-endurance drone swarms. To address these problems, a novel compact concept of a high-TWR of MTE with a double-sided composite impeller (DSCI) is proposed in this research. First, the principle and structure of the concept are explained through theoretical analysis, and its potential advantages are discussed. Second, the DSCI is analyzed at the top level, and the design principle and important parameters are discussed. The DSCI and supporting jet engine are preliminarily designed. Then, their weight is estimated. Finally, theoretical analytical and numerical simulations are used to preliminarily research the performance parameters of DSCI jet engine at the design point, and the parameters are discussed. These calculations showed encouraging results, with all components of the DSCI jet engine meeting matching characteristics. Compared to the JetCat P500-PRO-GH, the DSCI jet engine has a 39.4% increase in TWR and a 36.82% decrease in specific fuel consumption (sfc). This study lays a foundation for the development of high energy/power density MTEs in the future.
PRDX-1 Supports the Survival and Antitumor Activity of Primary and CAR-Modified NK Cells under Oxidative Stress
Authors: Klopotowska Marta , Bajor Malgorzata , Graczyk-Jarzynka Agnieszka , Kraft Agnieszka , Pilch Zofia , Zhylko Andriy , Firczuk Malgorzata , Baranowska Iwona , Lazniewski Michal , Plewczynski Dariusz , Goral Agnieszka , Soroczynska Karolina , Domagala Joanna , Marhelava Katsiaryna , Slusarczyk Aleksander , Retecki Kuba , Ramji Kavita , Krawczyk Marta , Temples Madison N. , Sharma Blanka , Lachota Mieszko , Netskar Herman , Malmberg Karl-Johan , Zagozdzon Radoslaw , Winiarska Magdalena
Published: December 2021

Oxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer. Here, we quantified hydrogen peroxide in the tumor microenvironment (TME) and demonstrated that hydrogen peroxide concentrations are elevated in tumor interstitial fluid isolated from murine breast cancers in vivo, when compared with blood or normal subcutaneous fluid. Therefore, we investigated the effects of increased hydrogen peroxide concentration on immune cell functions. NK cells were more susceptible to hydrogen peroxide than T cells or B cells, and by comparing T, B, and NK cells' sensitivities to redox stress and their antioxidant capacities, we identified peroxiredoxin-1 (PRDX1) as a lacking element of NK cells' antioxidative defense. We observed that priming with IL15 protected NK cells' functions in the presence of high hydrogen peroxide and simultaneously upregulated PRDX1 expression. However, the effect of IL15 on PRDX1 expression was transient and strictly dependent on the presence of the cytokine. Therefore, we genetically modified NK cells to stably overexpress PRDX1, which led to increased survival and NK cell activity in redox stress conditions. Finally, we generated PD-L1–CAR NK cells overexpressing PRDX1 that displayed potent antitumor activity against breast cancer cells under oxidative stress. These results demonstrate that hydrogen peroxide, at concentrations detected in the TME, suppresses NK cell function and that genetic modification strategies can improve CAR NK cells' resistance and potency against solid tumors.
Patient-Reported Outcomes in Free-Flap Breast Reconstructive Surgery over Time (PRO-BREST)
Authors: Fontein Duveken B.Y. , Oros Melanie , Held Leonhard , Giovanoli Pietro , Pusic Andrea L. , Lindenblatt Nicole
Published: December 2021

Introduction: Patient-reported outcomes (PROMs) are increasingly relevant to assess surgical quality and guide decisions in breast reconstruction (BR). Satisfaction with outcomes may change as time progresses. We assessed satisfaction in patients who underwent free-flap BR in the last 12 years. Methods: All patients who underwent free-flap BR from 2006 to 2018 were invited to complete the validated BREAST-Q for reconstruction. The BREAST-Q comprises 6 domains covering various aspects of satisfaction. Unadjusted linear regression assessed the relationship between different domains of the BREAST-Q and time since BR. Two-sample t tests assessed differences in satisfaction between patients who underwent BR ≥5 years versus <5 years prior. Results: Forty-three women with primary or secondary free-flap BR between 2006 and 2018 were included in the study. Most patients (n = 33, 76.7%) underwent DIEP flap BR. Overall satisfaction with breasts and with outcomes improved as time since BR increased (p = 0.031 and p = 0.017, respectively). Overall satisfaction with outcomes scored higher in patients with BR ≥5 years prior (≥5 years vs. <5 years: breast score 88.6 (SD 12.5) versus 66.9 (SD 21.8); p = 0.005). Satisfaction with breasts and psychosocial well-being also scored higher in these patients. There was no difference in results between primary and secondary BR. Patients who underwent additional surgery (refinements) reported higher satisfaction with outcomes and abdominal well-being. Conclusions: PROMs concerning satisfaction with breast and with outcomes following BR improve as time since treatment progresses. This study demonstrates that time since diagnosis may be an important factor in satisfaction. It underlines the importance of long-term PROMs related to BR, to help provide patients and health care professionals in decision-making and in managing expectations related to BR.
A Thesaurus of Old English
Authors: Roberts Jane
Published: December 2021

The Thesaurus of Old English (TOE), first published in 1995, had its origins in a body of slips derived from standard dictionaries, principally the Clark Hall and Merritt Concise Anglo-Saxon Dictionary and the Bosworth-Toller volumes. These slips were made to supply the Glasgow Historical Thesaurus (HT) project (1965–2009) with a firmer idea of the range and totality of Old English vocabulary than available in the OED. In 1976 the decision was taken to deploy the Old English materials as a pilot thesaurus for the HT. With compilation of the slips completed in 1982, researchers were able to begin sorting the slips into groupings based on meaning and to see areas of the HT classification take shape in miniature. The TOE data, absorbed into the larger structure of its parent project, allow us to view English words that disappeared by 1150 alongside those that continued in use.
Characterization of ground parenchyma cells in Moso bamboo (Phyllostachys edulis–Poaceae)
Authors: Lian Caiping , Chen Hong , Zhang Shuqin , Liu Rong , Wu Zhihui , Fei Benhua
Published: December 2021

Ground parenchyma cells play a crucial role in the growth and the mechanical properties of bamboo plants. Investigation of the morphology of ground parenchyma cells is essential for understanding the physiological functions and mechanical properties of these cells. This study aimed to characterize the anatomical structure of bamboo ground parenchyma cells and provide a qualitative and quantitative basis for the more effective utilization of bamboo. To do this, the morphology of ground parenchyma cells in Moso bamboo (Phyllostachys edulis) was studied using light microscopy and field-emission environmental scanning electron microscopy. Results show that various geometric shapes of ground parenchyma cells were observed, including nearly circular, square, long, oval, and irregular shapes. Cell walls of both long and short parenchyma cells exhibited primary wall thickening and secondary wall thickening, resulting in a primary pit field and simple pits. Most long cells were strip-shaped (L/W = 2.52), while most short cells were short and wide (L/W = 0.59). The proportion of long cells was 11 times greater than that of short cells. Most long cells were filled with starch grains, and some short cells also occasionally had starch grains. These findings allowed the first construction of the three-dimensional structure of parenchyma cells.
Record of the subgenus, Gryllitara Chopard, 1931 (Orthoptera: Gryllidae: Itarinae) and description of a new species from India
Authors: MEENA ASHOK KUMAR , SWAMINATHAN RAJAMANI , NAGAR RAJENDRA , CHHANGANI GAURANG , KUMAR KULDEEP
Published: December 2021

In the present paper, we report the occurrence of the cricket subgenus Gryllitara Chopard, 1931 from India along with the description of a new species, Itara (Gryllitara) pilosa sp. nov., from the state of Kerala, South India. Suitable plates with close-up details have been presented to describe the new species, as well as for Itara (Itara) vietnamensis Gorochov being reported from North East India.
Study on the university students' satisfaction of the wisdom tree massive open online course platform based on parameter optimization intelligent algorithm
Authors: Lee Chou-Yuan , Ruan Ling-Ming , Lee Zne-Jung , Huang Jian-Qiong , Yao Jie , Ning Zheng-Yuan , Tu Jih-Fu
Published: December 2021

Introduction:

Curriculum learning through the wisdom tree massive open online course platform not only gets rid of the limitations of specialty, school and region, eliminates the limitations of time and space in traditional teaching, but also effectively solves the problem of educational equity.

Objectives:

This paper proposes an intelligent algorithm combining decision tree, support vector machine, and simulated annealing to obtain the best classification accuracy and decision rules for university students' satisfaction with the wisdom tree massive open online course platform.

Methods:

This study takes the university students in Fuzhou city information management department as the survey object, and adopts the electronic questionnaire survey method. A total of 1136 formal questionnaires were responded, and 1028 valid questionnaires were obtained after data cleaning and deleting invalid questionnaires (the effective rate was 90.49%). In this paper, the reliability and validity of the questionnaire were tested by IBM SPSS-20.0 software, and six explanatory variables including function, achievement, exercise, quality, richness, and interaction were obtained by principal component analysis. Then, the questionnaire data is converted to CSV (comma separated values) format for analysis. This paper proposes an intelligent algorithm combining decision tree, support vector machine, and simulated annealing to obtain the best classification accuracy and decision rules for university students' satisfaction with the wisdom tree massive open online course platform. In this paper, the proposed algorithm is compared with decision tree, random forest, k-nearest neighbor, and support vector machine to verify its performance.

Results:

The experimental results show that training set classification accuracy of decision tree, random forest, k-nearest neighbor, only support vector machine and the proposed algorithm (simulated annealing + support vector machine) are 92.21%, 96.10%, 95.67%, 97.29%, and 99.58%, respectively.

Conclusion:

The proposed algorithm simulated annealing + support vector machine does increase the classification accuracy. At the same time, the 11 decision rules generated by simulated annealing + decision tree can provide useful information for decision makers.