bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis, and Investigation of Cytotoxic Effects of 5-Hydroxyindole-3-Carboxylic Acid and Ester Derivatives as Potential Anti-breast Cancer Agents
Authors: Teymori Arezo , Mokhtari Shaya , Sedaghat Anna , Mahboubi Arash , Kobarfard Farzad
Published: June 2023

: Breast cancer is a deadly disease with a high prevalence rate among females. Despite several treatments, scientists are still engaged in finding less invasive treatments for this disease. The cellular proliferation rate and cell viability survey are critical to assess the drug’s effect on both normal and malignant cell populations. Indole derivatives are promising candidates for their cytotoxic effect causing on breast cancer cells; however, they are less toxic on normal cells. This study synthesized 23 novel 5-hydroxyindole-3-carboxylic acids and related esters featuring various linear, cyclic, and primary aromatic amines. The MTT assay indicated the cytotoxicity of all acid and ester derivatives against the MCF-7 cells with no significant cytotoxicity on normal human dermal fibroblasts cells. Compound 5d, an ester derivative possessing a 4-methoxy group, was the most potent compound, with a half-maximal effective concentration of 4.7 µM. Compounds 5a, 5d, and 5l bearing ester group in their structure demonstrated cytotoxicity values < 10 µM against the MCF-7 cell line and were safe for advanced screening.
The Evolutionary Transformation of Games: Digital Games and Children s Cyber Security
Authors: KAYA Ümit Ünsal , KARACA Nezahat Hamiden
Published: June 2023

In the digitalized world, there are changes in people's behaviours and reactions. A good example of this is observed in children in the context of digital games replacing traditional games. Today, children tend to meet their entertainment needs through digital games outside of school, usually in closed and safe spaces. Although digital games have positive aspects associated with cognitive development and intelligence, excessive playing of these games or not paying attention to age criteria can threaten children's physical and mental health. In addition, children may have poor academic performance and behavioural problems. Unfortunately, children's cyber security can also be jeopardized in digital games played over the network without supervision. In this context, this study was carried out considering the need for a study that compiles the types of digital games, the positive and negative effects of digital games on children, the criteria that can guide parents in the selection of digital games, and awareness-raising initiatives in the field of digital games in Turkey based on the current literature. It is aimed that the study will contribute to educators and parents in terms of obtaining information and developing attitudes and contribute to this literature.
Studi Eksperimen Terhadap Model Pembelajaran Anak
Authors: Elvandari Maulana
Published: June 2023

Pendidikan telah bergeser pada faktor peserta didik yang harus didorong semakin aktif dalam proses pembelajaran sehingga mereka terlibat secara aktif dan terwujud pembelajaran yang meaningful. Bukan hanya itu pembelajaran juga harus merangsang pemikiran kritis peserta didik, karena dengan hal tersebut akan terbentuk sebuah pola baru dalam aspek keilmuan yang pada saatnya nanti akan lahir sebuah teori-teori baru. Oleh karena itu, perencanaan dan perkembangan pembelajaran harus sesuai dengan perkembangan IPTEK. Pembelajaran harus selalu bergerak dengan keberlanjutan sebuah sistem sehingga pendidikan menghasilkan peserta didik yang dapat menjawab tantangan perkembangan zaman, bahwa yang akan melakukan perubahan ke arah yang lebih baik.

Ada beberapa bentuk desain eksperimen yang dapat digunakan dalam penelitian baik untuk skripsi, tesis, maupun disertasi yaitu: Pre-Experimental Design, True Experimental Design, Factorial Design, dan Quasi Experimental Design. Ciri utama true experimental design ialah sampel yang dipakai untuk kelompok eksperimen maupun kontrol diambil secara acak dari populasi tertentu. Ada dua bentuk true experimental design yakni Posttest Only Control Design dan Pretest Group Design. Faktorial design adalah bentuk modifikasi atas true experimental design. Quasi Experimental Design juga merupakan pengembangan dari true experimental design, namun desain ini cenderung sulit dilaksanakan.

Peserta didik dapat diarahkan untuk melakukan eksperimen terkait dengan materi pembelajaran. Namun dengan metode pembelajaran yang mendorong setiap peserta didik untuk aktif melakukan percobaan mereka akan semakin aktif, tidak lagi anak yang melamun atau mengantuk ketika pembelajaran berlangsung. Hal ini menjadikan setiap peserta didik semakin antusias dalam proses pembelajaran yang sedang berlangsung.Peserta didik melakukan eksperimen dengan mengamati sifat-sifat benda tersebut setelah dilakukan berbagai perlakuan misalnya apakah benda tersebut konduktor atau isolator, peserta didik mendekatkan api pada benda tersebut. Melalui pembelajaran dengan menggunakan metode eksperimen peserta didik menjadi paham terhadap suatu materi karena peserta didik menemukan sendiri.
Menumbuhkan Jiwa Kepemimpinan Sejak Dini
Authors: Syaifur Rohman
Published: June 2023

Negara membutuhkan generasi terbaik yang mempunyai kemampuan memimpin bangsa ini guna mencapai kejayaan di masa depan. Pemuda-pemuda saat ini adalah pemimpin bangsa di masa depan, mereka akan menerima tongkat estapet kepemimpinan bangsa sehingga mereka harus dibekali dengan kecakapan-kecakapan dasar kepemimpinan .Inilah cita-cita pemuda yang akan menjadi pemimpin bangsa masa depan. Kepemimpinan dalam bahasa inggris disebut Leadership dan dalam bahasa arab disebut Zi’amah atau Imamah . dalam terminologi yang dikemukakan oleh Marifield dan Hamzah Kepemimpinan adalah menyangkut dalam menstimulasi, memobilisasi, mengarahkan, mengkoordinasi motif-motif dan kesetiaan orang-orang yang terlibat dalam usaha bersama. Kepemimpinan merupakan bagian dari fungsi-fungsi manajemen yang menduduki posisi strategis dalam sistem dan hirarki kerja dan tanggung jawab pada sebuah organisasi. Seorang pemimpin harus sanggup bekerja dalam jangka panjang dan dalam waktu yang tidak tertentu. Hal tersebut tercermin dalam keteguhan pendiriannya, kemauan yang keras dalam bekerja dan penerapan sifat-sifat pribadi yang baik dalam pekerjaannya

Inti pelajaran kepemimpinan untuk siswa SD adalah kegiatan menghormati dan saling mempercayai, serta membuat koneksi emosional dan komitmen untuk menyelesaikan tugas-tugas. Dalam kehidupan di kelas, penting bagi siswa SD untuk merasakan atmosfer kepemimpinan, dimana guru harus memberikan kesempatan yang menjanjikan bagi siswa untuk memperbesar konsepsi kepemimpinan mereka dengan menghubungkan emosi dirinya sendiri dengan gairah untuk melayani teman sebaya, disiplin dalam mendengarkan pendapat guru ataupun teman sebayanya, dan berani dalam bertanya. Mendengarkan dengan rasa ingin tahu adalah tindakan kreatif yang paling kuat yang dapat dilakukan, karena mendengarkan adalah pintu dimana anak membiarkan dunia luar untuk masuk. Kegiatan mendengarkan dapat meningkatkan komunikasi interpersonal, memperkuat keterampilan anak, menciptakan makna bersama, mengembangkan kemitraan bersama, dan berpartisipasi dalam kegiatan kepemimpinan bersama di dalam kelas ataupun di sekolah. Pemecahan masalah, imajinasi, dan perilaku prososial adalah aspek kepemimpinan yang dapat dipelajari pada anak sekolah dasar. Tapi hal seperti itu bukan prioritas kebutuhan anak, anak harus diberikan kegiatan pembelajaran yang dapat mengembangkan sikap kepemimpinan mereka di sekolah, karena anak memiliki kecerdasan untuk memberikan kepemimpinan, dan mereka juga harus mengembangkan keterampilan sosial yang efektif dalam rangka untuk mengambil posisi kepemimpinan dimasa yang akan datang.
Serum Nuclear Factor Erythroid-2 Related Factor-2 (NRF2) as an Indicator of Oxidative Stress is Related to Coronary in-Stent Restenosis
Authors: Coskun Ferhat , Vuruskan Ertan , Duzen Irfan Veysel , Kaplan Mehmet , Altunbas Gokhan , Bozdayi Mehmet Akif , Kazaz Tanyeli Guneyligil , Taysi Seyithan , Sucu Murat
Published: June 2023

Objective: In the treatment of coronary artery disease, stent implantation has become the standard treatment, but development of in-stent restenosis (ISR) limits the benefit of this treatment modality.
Methods: Based on the connection between oxidative stress and thiol/disulphate and NRF2, it was intended to measure NRF2 and thiol/disulphate levels.
Results: Coronary angiography images of 76 stable angina pectoris patients were evaluated. Of the 51 patients with a history drug eluting stent implantation, we determined 25 patients with ISR (Group 1) and 26 patients without ISR (Group 2). Twenty-five patients with normal coronary arteries were included in the study as control group (Group 3). NRF2 level was found to be significantly higher in patients who did not develop ISR (p=0.01). Total thiol was significantly higher in group 3 (738.76 micromole/L) compared to group 1 (626.11 micromole/L) and group 2 (630.27 micromole/L) (p=0.014). Native thiol was also significantly higher in group 3 (570.53 micromole/L) compared to group 1 (483.91 micromole/L) and group 2 (501 micromole/L) (p=0.006).
Conclusion: We think that total and native thiol levels might be useful as an indicator of oxidative stress in early diagnosis of coronary artery disease, and the NRF2 level can be used in predicting patients who might develop coronary ISR.
Returning home: the reintegration dilemmas of female Al-Shabaab defectors in Kenya
Authors: Badurdeen Fathima Azmiya
Published: June 2023

Gendered responses to the disengagement and reintegration of female defectors are needed to respond to trends that indicate increasing female radicalisation and growth in the recruitment of women into terrorist networks. The development of successful gender-sensitive amnesty policies and reintegration programmes is crucial, not only to prevent recidivism and re-engagement among female defectors, but also to mitigate the risk of further female radicalisation and recruitment at community level. This article, based on research conducted with female Al-Shabaab defectors in Kenya, explores women’s gendered motives for joining the Al-Shabaab network, their experiences within it and their reasons for quitting in order to inform an evidence-based reintegration process. It identifies the gendered nuances involved in recruitment, disengagement and deradicalisation, and it also considers gender-specific aspects of reintegration, highlighting the need to focus on gendered needs, norms and the expectations of female Al-Shabaab defectors and the communities in which they are reintegrated.
Update on the management of intracranial hypertension in urgent and emergency situations
Authors: Jesús Llorente Fernández
Published: June 2023

Justificación: La Hipertensión intracraneal (HIC) se relaciona con la mitad de muertes asociadas a lesiones cerebrales traumáticas, aumentando dicha mortalidad cuanto mayores son los niveles de Presión intracraneal. La medición de la PIC en situaciones de urgencias intrahospitalarias es importante, pero debemos conocer la forma de disminuirla si sospechamos de la misma en el ámbito extrahospitalario, puesto que la medición no es tan viable. Hay gran diversidad de tratamientos, pero es interesante saber cuáles son los más efectivos para elegir adecuadamente en situaciones de urgencia y de esa forma disminuir el riesgo de Hipertensión intracraneal y de mortalidad

Justification: Intracranial Hypertension (ICH) is related to half of the deaths associated with traumatic brain injuries, such mortality increasing the higher the levels of intracranial pressure. The measurement of ICP in intrahospital emergency situations is important, but we must know how to reduce it if we suspect it in the extrahospital setting, since the measurement is not as viable. There is a great diversity of treatments, but it is interesting to know which are the most effective to choose appropriately in emergency situations and thus reduce the risk of intracranial hypertension and mortality.
APAP versus titulation: Advancing towards telemedicine
Authors: Susana Pérez Casado , Rosa Eva Fernández Benito
Published: June 2023

El tratamiento adecuado para el SAHS (Síndrome de Apnea-hipopnea del Sueño) es la CPAP (Presión Positiva Continua de las vías respiratorias), que ha evolucionado hasta la aparición de la AutoCPAP (Presión Positiva Continua de las vías respiratorias automática), con mayor confort y prestaciones en los años 90. El aumento progresivo de la utilización de CPAP para el tratamiento del SAHS y los avances tecnológicos experimentados por las APAPs (AutoCPAP), permiten realizar un control remoto y reduce costes respecto a la titulación. Podemos exponer que, en general, la APAP nos aporta la información necesaria para realizar un buen manejo de los pacientes con SAHS, ajustando los parámetros, sin necesidad de titular a los pacientes en los centros sanitarios.

The appropriate treatment for SAHS (Sleep Apnea-Hypopnea Syndrome) is CPAP (Continuous Positive Airway Pressure), which has evolved to the onset of AutoCPAP (Continuous Positive Airway Pressure automatic), with greater comfort and performance in the 90s. The progressive increase in the use of CPAP for the treatment of SAHS and technological advances experienced by APAPs (AutoCPAP), allow a remote control and reduces costs with respect to titling. We can state that, in general, the APAP provides us with the necessary information toperform a good management of patients with SAHS, adjusting the parameters, without need to register patients in health centers.
Các nhân tố ảnh hưởng đến tính tuân thủ thuế của người nộp thuế thu nhập cá nhân: Nghiên cứu trường hợp chi cục thuế quận 11, Tp. HCM
Authors: Nguyễn Bá Hoàng
Published: June 2023

Mục tiêu của bài nghiên cứu nhằm xác định các nhân tố ảnh hưởng đến tính tuân thủ thuế của người nộp thuế thu nhập cá nhân (TNCN) tại Chi cục thuế Quận 11, Tp. Hồ Chí Minh. Dữ liệu của nghiên cứu được thu thập từ hơn 200 người nộp thuế TNCN tại Chi cục thuế Quận 11, Tp. Hồ Chí Minh. Các phương pháp kiểm định Cronbach’s Alpha, phương pháp phân tích nhân tố khám phá (EFA) và hồi quy tuyến tính đa biến được sử dụng trong nghiên cứu này. Kết quả nghiên cứu đã chỉ ra rằng, các nhân tố hiểu biết thuế và nhân tố nhận thức về tính công bằng thuế có ảnh hưởng tích cực đến tính tuân thủ thuế của người nộp thuế TNCN.
PENGARUH DESAIN INTERIOR TERHADAP MINAT PENGUNJUNG DI MARRIOTT HOTEL HARBOUR BAY KOTA BATAM
Authors: Dailami  , Moh. Thandzir  , Haufi Sukmamedian  , Nensi Lapotulo
Published: June 2023

Interior design is all about aesthetic value as well as providing comfort and appeal to visitors. In addition to increasing the attractiveness of visitors, the interior and layout arrangement can also increase the value of the existence of the place. The appearance and layout are important in creating a comfortable room and can also affect the mood, views and interest of buyers to visit the place. This study was made with the aim of describing the effect of interior design and layout on consumer attractiveness at Anchor Cafe & Roastery Batam. The method used by the researcher is a quantitative method.
DOCUMENTS OF PERSONAL ORIGIN OF RUSSIAN JURORS OF THE 1860s — 1890s AS A HISTORICAL SOURCE
Authors:   RANEPA, Demichev Aleksey A. ,   Nizhny Novgorod Academy of the Ministry of Internal Affairs of Russia
Published: June 2023

The article studies the private documents of jurors of the Russian Empire such as diaries and memoirs and analyses them as a complex of historical sources containing unique information about the course of the trial and the work of the jury. The pool of documents included two diaries and eight memoirs. The author evaluated the authorship, purpose, place of creation of these documents as well as their content and cognitive value. It is noted that the memoirs under the study share the features which are characteristic of most memoirs of the second half of the 19th — early 20th centuries: they were originally aimed at publication and intended primarily for contemporaries; the time gap between the original events and the “memories” of them was relatively short (from several months to several years). The selected documents are primarily the ones belonging to jurors who participated in the metropolitan district courts trials. This fact narrows our understanding of the work of jury in the Russian Empire in the 19th century down to metropolitan provinces.
VLADIVOSTOK COMMERCIAL SEAPORT IN THE FIRST HALF OF THE 1920s: EXPORT COMPETITION AND INTERDEPARTMENTAL CONTRADICTIONS
Authors:   Far Eastern Federal University, Gudkov Ilya A.
Published: June 2023

The article is devoted to the problem of the development of the Vladivostok commercial port in the early 1920s. The first quarter of the XX century was a time of severe trials for the whole of Russia in general and the Far East in particular: World War I; Civil War; foreign intervention. All this time, the Vladivostok Harbor was in fact the only source of external contacts of the remote region. Being the largest Russian port on the Pacific Ocean, Vladivostok has historically been a kind of center of attraction, both in socio-economic and military-political aspects. However, the destroyed logistics chains and the colossal damage that the era of political instability brought with it deprived him of the primacy in the struggle for the markets of the Pacific Rim. This publication is based on archival documents, many of which are being introduced into scientific circulation for the first time. The author sets himself the task of demonstrating the key activities of the central and local authorities aimed at restoring the competitiveness of the Vladivostok commercial port in the «Manchurian transit» — its distinctive «Visiting card» since the beginning of the century. The author concludes that despite the cardinal change in the vector of the country's political and economic development after 1917, the port of Vladivostok managed to retain the status of the Russian «Window to Asia». The key means of implementing these plans was the establishment of the so-called «Transit harbor» in the port, which became the logical result of generalization and application of the colossal pre-revolutionary experience in the functioning of «free economic zones».
Confusion and convergence, but no "myth of randomness." Chapter 2 of From Extraterrestrials to Animal Minds
Authors: Matheson Stephen
Published: June 2023

The concept of randomness is caught up in evolution, in two broad ways. The first and most famous aspect is the oft-misunderstood randomness of mutation. The second aspect is the role of chance in the trajectory of evolution. It is this question—is evolution predictable, or is it a random "drunkard's walk"—that Conway Morris tackles in the second chapter of From Extraterrestrials to Animal Minds: Six Myths of Evolution.
Open Inaccessibility
Authors: Hartgerink Chris
Published: June 2023

In my decade working on the openness of research I touched upon content accessibility only a few times, in part because it was and is a less discussed topic in my circles. But that does not make it less important. After all: When a PDF is downloaded, who can read
Citation Style Language 1.0.1 Update
Authors: Zelle Rintze M.
Published: June 2023

The Citation Style Language (CSL) team is happy to announce CSL 1.0.1. CSL 1.0.1 is an (almost completely) backwards compatible release, and CSL 1.0 styles and locale files don’t have to be updated to work with CSL 1.0.1-compatible software. CSL 1.0.1 is a relatively minor update, but adds a variety of new features to CSL, and an extra layer of polish to both the specification and schema. The CSL 1.0.1 specification is accompanied by CSL 1.0.1 release notes, which give a comprehensive...
What if Greta Thunberg took a Shell-sponsored professorship?
Authors: Brembs Björn
Published: June 2023

Or let’s think a a few sizes smaller and imagine a renowned pulmonologist taking the, say, “Marlboro Endowed Chair” in the Mayo Clinic’s Pulmonary Medicine Division, sponsored by Philip Morris. What would they have to endure and how much credibility would they and the institutions lose? Undoubtedly, the foul stench of corruption and hypocrisy would be difficult to counter.
Mendeley Donates to the CSL Project
Authors: Zelle Rintze M.
Published: June 2023

CSL has seen a lot of growth in recent years: more than 20 software products use CSL (see the citationstyles.org frontpage), and we offer over 6750 free citation styles, covering thousands of scientific journals. We could only have come this far with our great user community, and with a lot of institutional support from Mendeley, Papers, Zotero, and others. Mendeley has been using CSL since their first release in 2008, and adopted Frank Bennett’s citeproc-js CSL processor in 2010. They...
Why publication services must not be negotiated
Authors: Brembs Björn
Published: June 2023

or: how journals are like 1930s Rolls Royce Phantom IIs Recently, the “German Science and Humanities Council” (Wissenschaftsrat) has issued their “Recommendations on the Transformation of Academic Publishing: Towards Open Access“. On page 33 they write that increasing the competition […] ↓ Read the rest of this entry...
How about paying extra for peer-review?
Authors: Brembs Björn
Published: June 2023

There are those who demand journal peer-review be paid extra on top of academic salaries. Let’s have a look at the financials of that proposal. The article linked above confirms common rates of academic consulting fees, i.e., anything between US$100 per hour for graduate students and US$350 per hour for faculty. Taking a conservative US$200 as an easy, lower-bound estimate for, say, a post-doc hour seems to cover most cases.
Dipping my toes into 3D
Authors: Hartgerink Chris
Published: June 2023

This week I am a bit at a loss what to write about - I had drafts on the weaponization of meta-research, how to write an R package in 2022 (but the year's almost out), the consequences of owning your digital...
The ideal taxonomic journal
Authors: Page Roderic
Published: June 2023

This is just some random notes on an “ideal” taxonomic journal, inspired in part by some recent discussions on “turbo-taxonomy” (e.g., https://doi.org/10.3897/zookeys.1087.76720 and https://doi.org/10.1186/1742-9994-10-15), and also examples such as the Australian Journal of Taxonomy https://doi.org/10.54102/ajt.qxi3r which seems well-intentioned but limited.
Library interfaces, knowledge graphs, and Miller columns
Authors: Page Roderic
Published: June 2023

Some quick notes on interface ideas for digital libraries and/or knowledge graphs. Recently there’s been something of an explosion in bibliographic tools to explore the literature.
Design Thinking: A Method for Building Creative Immunity
Authors: Sathe Tejas S.
Published: June 2023

One of the most counter-intuitive principles when applying design thinking to healthcare and surgery specifically is the idea that quantity of ideas is initially more important than quality of ideas.
Reflections on "The Macroscope" - a tool for the 21st Century?
Authors: Page Roderic
Published: June 2023

This is a guest post by Tony Rees. It would be difficult to encounter a scientist, or anyone interested in science, who is not familiar with the microscope, a tool for making objects visible that are otherwise too small to be properly seen by the unaided eye, or to reveal otherwise invisible fine detail in larger objects.
Interacting learning systems at SfN22
Authors: Brembs Björn
Published: June 2023

I just sent the poster for this year’s Society for Neuroscience meeting to the printer. As our graduate student is preparing his defense and our postdoc did not get a visa (no thanks, US!), we just have a single poster this year and I will present it myself on Monday, November 14, 2022, 8:00 AM – 12:00 PM, on poster board WW53.
Open Access and the incentives for embezzlement
Authors: Brembs Björn
Published: June 2023

Wikipedia defines ‘embezzlement‘ as “the act of withholding assets for the purpose of conversion of such assets”. Google defines it as “misappropriation of funds placed in one’s trust”: If one takes the position that researchers at public institutions are entrusted with public funds to spend on research in the public interest, then researchers spending public funds on something that mainly benefits them

personally

rather than the
Remarks on barriers to Open Science for ECRs
Authors: Hartgerink Chris
Published: June 2023

Yesterday was the first of four listening sessions by the White House's Office of Science and Technology Policy.
JSON-LD in the wild: examples of how structured data is represented on the web
Authors: Page Roderic
Published: June 2023

I've created a GitHub repository so that I can keep track of the examples of JSON-LD that I've seen being actively used, for example embedded in web sites, or accessed using an API. The repository is https://github.com/rdmpage/wild-json-ld. The list is by no means exhaustive, I hope to add more examples as I come across them. One reason for doing this is to learn what others are doing.
Duplicate DOIs (again)
Authors: Page Roderic
Published: June 2023

This blog post provides some background to a recent tweet where I expressed my frustration about the duplication of DOIs for the same article. I'm going to document the details here.
The joy of compounding skillsets
Authors: Hartgerink Chris
Published: June 2023

Starting a small company means the buck stops with me on everything, every time. Since founding Liberate Science three years ago, that means I’ve had to pick up a lot of skills.
Problems with Plazi parsing: how reliable are automated methods for extracting specimens from the literature?
Authors: Page Roderic
Published: June 2023

The Plazi project has become one of the major contributors to GBIF with some 36,000 datasets yielding some 500,000 occurrences (see Plazi's GBIF page for details). These occurrences are extracted from taxonomic publication using automated methods.
Remarks for the Berlin Publishing Conference 2023
Authors: Hartgerink Chris
Published: June 2023

💡These are my remarks for the junior researcher panel at the APE2023 conference. This blog is slightly edited for clarity and expands the quote selection from Aaron Swartz.Aaron Swartz died a decade ago today - to commemorate him I’ll start by reading selected quotes from the Guerilla Open Access Manifesto here today.Information is power. But like all power, there are those who want to keep it for themselves. […] Sharing isn't immoral — it's a moral imperative....
DNA barcoding as intergenerational transfer of taxonomic knowledge
Authors: Page Roderic
Published: June 2023

I tweeted about this but want to bookmark it for later as well. The paper “A molecular-based identification resource for the arthropods of Finland” doi:10.1111/1755-0998.13510 contains the following: I think this is a very clever way to characterise the project. In an age of machine learning this may be commonest way to share knowledge , namely as expert-labelled training data used to build tools for others.
ÜSTÜNLÜK TEORİSİ BAĞLAMINDA TEYO PEHLİVAN FIKRALARI
Authors: BEDİR Ali
Published: June 2023

Anlatmaya dayalı türler arasında yer alan fıkra türü, toplumun bilinçaltında yer edinen unsurları, zevkleri, deneyimleri, eğitimsel unsurları, kültürü ve güldürü unsurlarını barındırır. Fıkra metinlerinin özellikleri arasında yer alan güldürürken düşündürme işlevi, mizah unsurunun oluşmasına zemin hazırlamaktadır. Mizah unsuru, çözümleme yapmayı ve yorumlamayı gerekli kılmaktadır. Mizah teorileri, mizah unsuru üzerinde çözümlemeler yapmanın sonucu olarak ortaya çıkmıştır. Mizah teorileri içerisinde yer alan üstünlük teorisi, mizah unsurunu oluşturan ve gülmeyi etkileyen üstünlük bildirici olgularla ilgilenir. Fıkra türünde, fıkra tiplerinin üstünlük amacıyla hareket etmeleri veya üstünlük bildiren tutum sergilemeleri sonucunda mizah unsuru oluşmaktadır. Çalışmamızın sınırlılığı Teyo Pehlivan fıkralarıdır. Çalışmamızın amacı; Teyo Pehlivan fıkralarını üstünlük teorisi bağlamında incelemektir. Araştırmamızın problemi ise Teyo Pehlivan fıkralarında üstünlük bildiren ifadelerin neler olduğu ve bu ifadelerin mizah unsurunu nasıl etkilediğidir. Araştırmamız metin merkezli bir çalışmadır. Öncelikle mizah teorileri içerisinde yer alan üstünlük teorisiyle ilgili genel ifadeler üzerinde duracağız. Üstünlük teorisinin fıkra metinlerine uygulanmasıyla ilgili ifadelere değineceğiz. Komik unsurunu oluşturan üstünlük olgularının neler olduğunu tespit etmeye çalışacağız. Literatür taramasından elde ettiğimiz verilerden hareketle Teyo Pehlivan fıkralarını ele alacağız. Teyo Pehlivan fıkralarında yer alan üstünlük ifadeleri ve mizah unsurlarıyla ilgili elde ettiğimiz verileri karşılaştırmalı olarak inceleyeceğiz. Fıkra metinlerinde ulaştığımız bulgulardan hareketle, mahallî fıkra tipi olan Teyo Pehlivan’ın güldürü özellikleri üzerinde duracağız.
Editorial Note
Authors: Ghaffar Dr. Robina
Published: June 2023

MDPIP in its journey as a publisher presents the second issue of its Open Access Organization and Management Review. This issue consists of five quantitative articles covering various aspects of the organization and managerial issues. The findings, interpretations, and conclusions expressed in these articles are entirely those of the researchers, thus, naturally MDPIP nor its Editorial Board bears responsibility for any shortcomings. The publication of the second issue was not possible without the cooperation of our Editorial Board and research experts on the review panel who spared their precious time and generously devoted their time and energies to thoughtfully review the assigned articles. We must express our sincerest appreciation and gratitude to them all.
Una revisión sistemática de la calidad educativa virtual en Perú
Authors: García Gutiérrez Ruth Betsabé , Huaman De La Cruz Delia , Tacilla Atalaya Juber
Published: June 2023

El objetivo del presente estudio fue analizar la calidad educativa virtual en la educación superior, describiendo sus principales características y componentes. Se observa en América Latina, que la calidad educativa presenta una problemática creciente, dado que se ha priorizado el incremento en la cobertura del servicio educativo, sin prestar importancia a los fines principales de la educación y formación profesional, por lo que se han manifestado un alto grado de abandono y repitencia (UNESCO, 2005). En cuanto a los modelos teóricos, se documenta el modelo de Moreno (2007), que considera factores básicos en la modalidad educativa a distancia, como son: expectativas, promesas, procesos clave, función estratégica y finalidad; asimismo, Pariente (2010) diseña un modelo de Comunidad Virtual de Aprendizaje con la dimensión intencional, pedagógica, personal, contextual y organizacional; mientras que, la calidad educativa en las modalidades a distancia y semipresencial, se determina a partir del modelo de Moreno (2005) y se evalúa con la escala de Servqual. En conclusión, la calidad educativa semipresencial en el Perú se considera deficiente, dado que existe un uso reducido de las tecnologías existentes y desconocimiento de las plataformas formativas disponibles, lo cual se agrava a partir de la realidad del sistema educativo nacional donde los docentes y las instituciones educativas no se encuentran preparadas para el desarrollo eficiente de esa nueva modalidad educativa.
Cybersecurity Framework Profile for Hybrid Satellite Networks (HSN)
Authors: McCarthy James , Mamula Dan , Brule Joseph , Meldorf Karri , Jennings Rory , Wiltberger John , Thorpe Chris , Dombrowski John , Lattin O'Ryan
Published: June 2023

The space sector is transitioning away from traditional vertically-integrated entities and towards Hybrid Satellite Networks (HSN) which is an aggregation of independently owned and operated terminals, antennas, satellites, payloads, or other components that comprise a satellite system. The elements of an HSN may have varying levels of assurance. HSNs may interact with government systems and critical infrastructure (as defined by the Department of Homeland Security). A framework is required to assess the security posture of the individual components while still enabling the HSN to provide its function. This report applies the NIST Cybersecurity Framework to HSNs with an emphasis on the interfaces between the participants of the HSN. In collaboration with subject matter experts including satellite builders, consultants, acquisition authorities, operators (commercial and government), academia, and other interested parties, the National Institute of Standards and Technology (NIST) has developed the HSN Cybersecurity Framework CSF Profile (HSN Profile) to guide space stakeholders. The resulting profile provides a starting point for stakeholders who are assessing the cybersecurity posture of their HSN.
Screening of Some Registered Turkish Barley Cultivars Reactions Against Rhynchosporium commune
Authors: ERTAS OZ Merve Nur , TURGAY Emine Burcu , BÜLBÜL Sibel , ERGÜN Namuk
Published: June 2023

Barley is one of the significant cereal used as hay and malt both in the world and in Turkey. There are several abiotic and biotic factors affecting the production and quality of barley. Of these factors, fungal diseases play a vital role. Especially, barley scald (Rhynchosporium commune), a fungal pathogen, is threating the barley grown areas in terms of the quality and the production. One of the most common methods in controlling of this fungal diseasis to develop resistant barley varieties. The study carried out in the laboratories and greenhouses of Field Crop Central Research Institute, Yenimahalle, Ankara in 2020-2021. Aim of this study was to investigate the reaction of 55 registered barley cultivars against barley scald. The results show that Erginel-90 is immun, as well Avcı-2002, Ocak, Kendal, Hevsel, Yükse, Şahin-91 and Akhisar-98 varieties are resistant. On the other hand, Yesevi-93, Tarm-92, Orza-96, Larende, Bülbül-89, Karatay-94 and Ayrancı are detected as susceptible to this disease.
Cultural Intelligence and Social Capital: Investigating expatriates’ working relationships in Malaysia
Authors:   , Leverenz Bishan
Published: June 2023

This thesis examines the effect of Cultural Intelligence on expatriates’ relationship quality with their culturally diverse host national work colleagues in Malaysia from a social capital perspective. Malaysia presents a highly culturally diverse host country which has increasingly become attractive for global organizations over the last few decades. A high-quality relationship with host national employees allows expatriates to access valuable resources which facilitate their adjustment and performance. Such resources represent expatriates’ social capital. However, it is still unknown why some expatriates are more successful in developing higher level of social capital with Host Country Nationals than others. Prior research shows that expatriates with higher level of Cultural Intelligence often feel more comfortable to interact with Host Country Nationals (HCNs). Therefore, Cultural Intelligence would be expected to have a positive impact on expatriates’ relationship quality with HCNs and, hence, improving social capital. The relationship between Cultural Intelligence and social capital is, however, under researched especially with little focus given to the effect of metacognitive, cognitive, motivational, and behavioural dimensions of Cultural Intelligence. Following mixed methods approach, this thesis uses quantitative survey and Multiple Linear Regression to identify general relationships between the four dimensions of Cultural Intelligence and expatriates’ social capital. Additionally, qualitative semi-structured interviews and Thematic Analysis are used to explore how and why Cultural Intelligence may influence expatriates’ development of social capital. The results suggest that expatriates’ metacognitive, motivational, and behavioural Cultural Intelligence have a positive effect on expatriates’ development of social capital. However, the effect of cognitive Cultural Intelligence is very limited. The qualitative findings provide insights on the challenges in expatriates’ work relationship with HCNs due to their cultural differences, and how the different dimensions of Cultural Intelligence may help to solve them, thereby contributing to expatriates’ development of social capital. One important finding concerns the mediating role of recognition and appraisal respect in facilitating expatriates’ development of social capital with their host national colleagues. This thesis contributes to the expatriate literature by being the first to examine how and why expatriates’ metacognitive, cognitive, motivational, and behavioural Cultural Intelligence may influence the development of social capital with their host national work colleagues. The findings of this thesis also have practical implications concerning the selection of future expatriates and the design of more effective training programs to enhance expatriates’ probability of success by receiving more useful resources from HCNs.
Time Charter or Trip Charter? An Assessment of Market Efficiency in Shipping Market
Authors: Pourkermani Kasra
Published: June 2023

This paper explores the economic value of charter hire rate forecasts in the bulk shipping industry for ship operators by introducing a chartering strategy defined as a sequence of different types of contracts that maximises profit. Ship operators are assumed to divide ship use to trip charter and time charter market depending on the quarterly excess charter hire rate forecasts, i.e. the difference between time charter and trip charter (spot) rates. Ship operators use the recursive forecasting approach and switch the chartering strategy across the two positions. The decision is based on economic measurement rather than statistical significance. The economic benefits realized by ship operators who apply our forecasting rules exceed those derived from the fixed policy approach of using either alternative, and will be used to disprove the validity of the efficient market hypothesis. The paper applies the regression methodology and forecasts two steps ahead of quarterly spot prices regressed recursively on fixed variables, thus extending research in terms of the scope of analysis. We have applied statistical evaluation in addition to the economic evaluation and found that the proposed model outperforms the historical mean forecast. This paper emphasizes the importance of a sound diversification strategy within the business platform to target the more profitable business segment and test if macroeconomic indicators and commodity prices are satisfactory indicators for forecasting charter hire rate.
Microcephaly-associated protein WDR62 shuttles from the Golgi apparatus to the spindle poles in human neural progenitors
Authors: Dell'Amico Claudia , Angulo Salavarria Marilyn M , Takeo Yutaka , Saotome Ichiko , Dell'Anno Maria Teresa , Galimberti Maura , Pellegrino Enrica , Cattaneo Elena , Louvi Angeliki , Onorati Marco
Published: June 2023

WDR62 is a spindle pole-associated scaffold protein with pleiotropic functions. Recessive mutations in WDR62 cause structural brain abnormalities and account for the second most common cause of autosomal recessive primary microcephaly (MCPH), indicating WDR62 as a critical hub for human brain development. Here, we investigated WDR62 function in corticogenesis through the analysis of a C-terminal truncating mutation (D955AfsX112). Using induced Pluripotent Stem Cells (iPSCs) obtained from a patient and his unaffected parent, as well as isogenic corrected lines, we generated 2D and 3D models of human neurodevelopment, including neuroepithelial stem cells, cerebro-cortical progenitors, terminally differentiated neurons, and cerebral organoids. We report that WDR62 localizes to the Golgi apparatus during interphase in cultured cells and human fetal brain tissue, and translocates to the mitotic spindle poles in a microtubule-dependent manner. Moreover, we demonstrate that WDR62 dysfunction impairs mitotic progression and results in alterations of the neurogenic trajectories of iPSC neuroderivatives. In summary, impairment of WDR62 localization and function results in severe neurodevelopmental abnormalities, thus delineating new mechanisms in the etiology of MCPH.
Genetic architecture of heart mitochondrial proteome influencing cardiac hypertrophy
Authors: Chella Krishnan Karthickeyan , El Hachem Elie-Julien , Keller Mark P , Patel Sanjeet G , Carroll Luke , Vegas Alexis Diaz , Gerdes Gyuricza Isabela , Light Christine , Cao Yang , Pan Calvin , Kaczor-Urbanowicz Karolina Elżbieta , Shravah Varun , Anum Diana , Pellegrini Matteo , Lee Chi Fung , Seldin Marcus M , Rosenthal Nadia A , Churchill Gary A , Attie Alan D , Parker Benjamin , James David E , Lusis Aldons J
Published: June 2023

Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mouse strains called the Hybrid Mouse Diversity Panel (HMDP). We performed a whole heart proteome study in the HMDP (72 strains, n=2-3 mice) and retrieved 848 mitochondrial proteins (quantified in ≥50 strains). High-resolution association mapping on their relative abundance levels revealed three trans-acting genetic loci on chromosomes (chr) 7, 13 and 17 that regulate distinct classes of mitochondrial proteins as well as cardiac hypertrophy. DAVID enrichment analyses of genes regulated by each of the loci revealed that the chr13 locus was highly enriched for complex-I proteins (24 proteins, P=2.2E-61), the chr17 locus for mitochondrial ribonucleoprotein complex (17 proteins, P=3.1E-25) and the chr7 locus for ubiquinone biosynthesis (3 proteins, P=6.9E-05). Follow-up high resolution regional mapping identified NDUFS4, LRPPRC and COQ7 as the candidate genes for chr13, chr17 and chr7 loci, respectively, and both experimental and statistical analyses supported their causal roles. Furthermore, a large cohort of Diversity Outbred mice was used to corroborate Lrpprc gene as a driver of mitochondrial DNA (mtDNA)-encoded gene regulation, and to show that the chr17 locus is specific to heart. Variations in all three loci were associated with heart mass in at least one of two independent heart stress models, namely, isoproterenol-induced heart failure and diet-induced obesity. These findings suggest that common variations in certain mitochondrial proteins can act in trans to influence tissue-specific mitochondrial functions and contribute to heart hypertrophy, elucidating mechanisms that may underlie genetic susceptibility to heart failure in human populations.
Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis
Authors: Ichinose Sotaro , Susuki Yoshihiro , Hosoi Nobutake , Kaneko Ryosuke , Ebihara Mizuho , Hirai Hirokazu , Iwasaki Hirohide
Published: June 2023

Neurons form dense neural circuits by connecting to each other via synapses and exchange information through synaptic receptors to sustain brain activities. Excitatory postsynapses form and mature on spines composed predominantly of actin, while inhibitory synapses are formed directly on the shafts of dendrites where both actin and microtubules (MTs) are present. Thus, it is the accumulation of specific proteins that characterizes inhibitory synapses. In this study, we explored the mechanisms that enable efficient protein accumulation at inhibitory postsynapse. We found that some inhibitory synapses function to recruit the plus end of MTs. One of the synaptic organizers, Teneurin-2 (TEN2), tends to localize to such MT-rich synapses and recruits MTs to inhibitory postsynapses via interaction with MT plus-end tracking proteins EBs. This recruitment mechanism provides a platform for the exocytosis of GABAA receptors. These regulatory mechanisms could lead to a better understanding of the pathogenesis of disorders such as schizophrenia and autism, which are caused by excitatory/inhibitory (E/I) imbalances during synaptogenesis.
Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line
Authors: Moradi Marjaneh Mahdi , Kirk Edwin P , Patrick Ralph , Alankarage Dimuthu , Humphreys David T , Del Monte-Nieto Gonzalo , Cornejo-Paramo Paola , Janbandhu Vaibhao , Doan Tram B , Dunwoodie Sally L , Wong Emily S , Moran Chris , Martin Ian CA , Thomson Peter C , Harvey Richard P
Published: June 2023

Unlike single-gene mutations leading to Mendelian conditions, common human diseases are likely to be emergent phenomena arising from multilayer, multiscale, and highly interconnected interactions. Atrial and ventricular septal defects are the most common forms of cardiac congenital anomalies in humans. Atrial septal defects (ASD) show an open communication between the left and right atria postnatally, potentially resulting in serious hemodynamic consequences if untreated. A milder form of atrial septal defect, patent foramen ovale (PFO), exists in about one-quarter of the human population, strongly associated with ischaemic stroke and migraine. The anatomic liabilities and genetic and molecular basis of atrial septal defects remain unclear. Here, we advance our previous analysis of atrial septal variation through quantitative trait locus (QTL) mapping of an advanced intercross line (AIL) established between the inbred QSi5 and 129T2/SvEms mouse strains, that show extremes of septal phenotypes. Analysis resolved 37 unique septal QTL with high overlap between QTL for distinct septal traits and PFO as a binary trait. Whole genome sequencing of parental strains and filtering identified predicted functional variants, including in known human congenital heart disease genes. Transcriptome analysis of developing septa revealed downregulation of networks involving ribosome, nucleosome, mitochondrial, and extracellular matrix biosynthesis in the 129T2/SvEms strain, potentially reflecting an essential role for growth and cellular maturation in septal development. Analysis of variant architecture across different gene features, including enhancers and promoters, provided evidence for the involvement of non-coding as well as protein-coding variants. Our study provides the first high-resolution picture of genetic complexity and network liability underlying common congenital heart disease, with relevance to human ASD and PFO.
Allele-specific gene-editing approach for vision loss restoration in RHO-associated retinitis pigmentosa
Authors: Liu Xiaozhen , Qiao Jing , Jia Ruixuan , Zhang Fan , Meng Xiang , Li Yang , Yang Liping
Published: June 2023

Mutant RHO is the most frequent genetic cause of autosomal dominant retinitis pigmentosa (adRP). Here, we developed an allele-specific gene-editing therapeutic drug to selectively target the human T17M RHO mutant allele while leaving the wild-type RHO allele intact for the first time. We identified a Staphylococcus aureus Cas9 (SaCas9) guide RNA that was highly active and specific to the human T17M RHO allele. In vitro experiments using HEK293T cells and patient-specific induced pluripotent stem cells (iPSCs) demonstrated active nuclease activity and high specificity. Subretinal delivery of a single adeno-associated virus serotype 2/8 packaging SaCas9 and single guide RNA (sgRNA) to the retinas of the RHO humanized mice showed that this therapeutic drug targeted the mutant allele selectively, thereby downregulating the mutant RHO mRNA expression. Administration of this therapeutic drug resulted in a long-term (up to 11 months after treatment) improvement of retinal function and preservation of photoreceptors in the heterozygous mutant humanized mice. Our study demonstrated a dose-dependent therapeutic effect in vivo. Unwanted off-target effects were not observed at the whole-genome sequencing level. Our study provides strong support for the further development of this effective therapeutic drug to treat RHO-T17M-associated adRP, also offers a generalizable framework for developing gene-editing medicine. Furthermore, our success in restoring the vision loss in the suffering RHO humanized mice verifies the feasibility of allele-specific CRISPR/Cas9-based medicines for other autosomal dominant inherited retinal dystrophies.