bluuebunny/crossref_metadata_2025 huggingface dataset:
Peningkatan Pendapatan Masyarakat Dengan Program Inovasi Desa Melalui Pengolahan Limbah Ikan Curah
Authors: Syahrinur Fitriah  , Nurida Isnaeni
Published: November 2023

The purpose of this community service is to test and train the community on the technology of making high protein fish feed pellets from trash fish waste which is useful for reducing the high purchase of fish feed on the market. Therefore, the need for a technology or innovation for the manufacture of fish feed in the community, especially areas where there is fish farming and is expected to reduce the high cost of purchasing feed. The method consists of presentations or training, mentoring and discussions, as well as analysis of business benefits. Members of the catfish breeding partners are mostly aged between 18 to 68 years, have elementary, junior high and high school education. The raw materials for the waste are 5 kg of dry trash fish, 100 g of tapioca flour/0.1 kg, 4.9 kg of rice bran and 1 l of diesel oil and plastic, so you can get up to 8 kg of fish pellets. with the cost required is IDR 39,050 Gross income IDR. 72,000 and a profit of Rp. 32,950. Comparing the benefits and costs incurred is IDR 32,950.00 :I DR 39,050.00 = 0.8 (B/C). Therefore, the fish pellet business is very profitable to develop and can increase the income of the Jati Emas villagers.
Penyuluhan Program Vaksinasi Booster Covid-19 Di Kabupaten Bengkayang
Authors: Novita Wanda , Wahyudi Raymond , Sebastian  , Alip Hanoky
Published: November 2023

Corona virus began to run the world in 2019, and started to enter Indonesia in 2020. The government of Indonesia then implemented an alert status telated to public health, and made effort to increase people’s immunity through various ways, where one of which is by vaccination. However, there is a lot of Indonesian refuse to take the vaccine due to their believe, and the massive publication in media that sayas a lot of people die since they had vaccination. Institut Teknologi dan Bisnis Sabda Setia collaborate with Dinas Kesehatan, Pengendalian Penduduk, dan Keluarga Berencana socializing the benefits of vaccination, especially the third vaccination called booster to the community in Bengkayang regency. The socialization attended by 100 people from all over Bengkayang. At the end of the socialization, both parties agreed to sign a declaration of the willingness of all officials to carry out the third vaccine.
Peningkatan Kapasitas Sumber Daya Manusia Melalui Kemampuan Literasi Dan Numerasi Sejak Dini
Authors: Akbar Idries Fahmy , Wahyusari N Febriani , Ikhsan Foster , Sutiono PN Budi
Published: November 2023

This service program focuses on the importance of literacy and numeracy in the industrial era 4.0 and the efforts made in Indonesia to improve these skills. Literacy is considered a basic need in meeting the needs of human life and developed countries have recognized the importance of literacy as a human right. However, in Indonesia, students' literacy and numeracy abilities are still lacking and have even decreased in recent years. Factors such as the lack of strengthening literacy, the impact of the Covid-19 pandemic, and sub-optimal distance learning have led to a decline in students' abilities. Therefore, the Indonesian government has set literacy as a priority program and strengthened the role of LP Maarif in developing literacy and numeracy. LP Maarif is trying to provide library facilities, develop an integrated curriculum, and provide training to teachers to become agents of literacy development. Hopefully, this effort can help elementary school students build their intelligence and improve their critical, strategic and solutive thinking skills in facing future challenges.
Peran Serta Masyarakat Dalam Upaya Pencegahan HIV AIDS Di Kelurahan Kalumpang
Authors: Tutik Lestari  , Ridwan Yamko  , Mudini Muhlis
Published: November 2023

In Indonesia the development of the spread of HIV AIDS every year shows an increase. Many efforts have been made involving all stakeholders and even the community to reduce the rate of spread of this disease, but there is no sign that this epidemic will end. HIV AIDS prevention has been regulated through a Minister of Health Regulation, where the involvement of community participation in efforts to prevent and control HIV AIDS through AIDS Care Citizens. Objective: to empower the community through the establishment of WPA in support of the HIV AIDS prevention program at the sub-district level. Method: activities through training involving representatives of community leaders and youth. Result: establishment of WPA Kalumpang Village consisting of 20 representatives of community leaders (health cadres, RT) and youth. Conclusion: community empowerment through WPA to prevent HIV AIDS transmission and HIV AIDS prevention at the Kalumpang Village level.
Peningkatan Kapabilitas Business Plan, Network, dan Marketing Guna Akselerasi Bisnis UMKM Sekolah Wirausaha Aisyiyah
Authors: Zulkifli Nurul Haqq  , Annisa Fajri
Published: November 2023

The development of the business world is currently experiencing significant developments. Massive digitalization is spreading in all aspects of human life, making the expertise to use a qualified digital device a must. With the emergence of new entrepreneurs, it is hoped that it will have a direct impact on improving people's welfare as well as accelerating economic progress and equity, increasing Indonesia's competitiveness through superior-based products and creative industries so as to create new jobs, as well as absorbing a large domestic market. on local products. In line with this, the community service collaboration team of the Management Study Program, Faculty of Economics, Universitas Muhammadiyah Semarang and Sekolah Wirausaha ‘Aisyiyah.
Validasi Kode OpenMC pada Reaktor Gas Berpendingin Helium Berbahan Bakar UC-PuC
Authors: Karomah Iklimatul , Syarifah Ratna Dewi , Trianti Nuri , Arkundato Artoto , Rohman Lutfi , Maulina Wenny , Purwandari Endhah , Hidayat Umar Sahiful
Published: November 2023

Validasi perhitungan kekritisan pada Gas Cooled Fast Reactor (GFR) menggunakan kode OpenMC dan SRAC telah dilakukan. OpenMC merupakan kode analisis neutronik yang bersifat open source dan probabilistik yang sedang dikembangkan oleh MIT hingga sekarang. Validasi kode OpenMC perlu dilakukan untuk menunjukkan hasil validitas perhitungan OpenMC dibandingkan dengan kode lainnya. OpenMC yang bersifat probabilistik, mensimulasikan random sampling partikel yang berjumlah besar. Hal terseut bertujuan untuk menunjukkan akurasi perhitungan OpenMC dengan menggunakan partikel yang berjumlah kecil. Validasi dilakukan dengan melihat selisih perhitungan nilai  dari kode OpenMC dan SRAC. Nilai konvergensi yang dihasilkan dari kode OpenMC dan SRAC dikatakan tervalidasi dengan memiliki nilai error <1%. Pada penelitian ini menggunakan 50.000 partikel dengan total pengulangan 100 batch aktif dan 30 batch tidak aktif yang disimulasikan. Hasil perbandingan menunjukkan bahwa OpenMC memiliki error maksimal 0,06% terhadap hasil perhitungan kode SRAC
Pemanfaatan Data Radar Cuaca Untuk Membuat Peringatan Dini Cuaca Secara Spasial Menggunakan Metode K-Means Cluster
Authors: Anjasman Anjasman
Published: November 2023

Pentingnya informasi cuaca untuk masyarakat tidak akan pernah lepas dari perkembangan teknologi yang ada. Semakin canggih teknologi, maka keadaan cuaca tersebut dapat diketahui, dipantau dengan cepat, tepat dan akurat. Untuk mengetahui dan memantau keadaan cuaca tersebut menjadi suatu informasi, maka diperlukan suatu cara dan metode untuk mengolahnya hingga menjadi suatu informasi yang berguna bagi masyarakat.Adapun tujuan dari penelitian ini adalah untuk membuat peringatan dini cuaca secara spasial dengan memanfaatkan data radar cuaca gematronik Bengkulu, yang mana data tersebut akan diolah menggunakan metode pengelompokkan K-Means Cluster sehingga menghasilkan suatu informasi peringatan dini cuaca secara spasial untuk menentukan daerah-daerah yang memiliki indeks tingkat kemungkinan banjir. Berdasarkan hasil penelitian, waktu yang dibutuhkan untuk mengelompokkan 2 kelompok tingkat kemungkinan adalah singkat (2 iterasi). Tingkat kemungkinan rendah memiliki cluster berwarna hijau dengan nilai 1 dan tingkat kemungkinan sedang-tinggi dengan nilai 2 berwarna jingga dan dapat dipetakan secara spasial pada batas administrasi kecamatan sehingga menjadi informasi peringatan dini cuaca.
PELATIHAN PEMBUATAN SABUN ORGANIK BERBAHAN DASAR MINYAK KELAPA UNTUK PEMBERDAYAAN WARGA DI DESA BARU KABUPATEN KAMPAR
Authors: Linda Tetty Marta , Purba Agnes Tasya , Fauzi Tiara Nurfadila , Rahayu Sri Jumaliza , Syahgiri Aldiyan , Nilandra Namira Ratu , Pangestu Adjie , Ramadhan Dhea Amanda , Respati Reno Widi , Wahyuni Levita , Fukuhara Shafira Keiko
Published: November 2023

Berdasarkan data yang tertera disebutkan bahwa mayoritas mata pencaharian masyarakat Desa Baru adalah petani dan buruh, diharapkan masyarakat desa dapat mengembangkan potensinya untuk menciptakan usaha dalam bentuk UMKM, sehingga mampu untuk menunjang ekonomi dan menjadi ciri khas Desa Baru. Sabun merupakan campuran senyawa natrium dengan asam lemak yang dapat digunakan sebagai pembersih, berbentuk padat, berbusa dengan atau tanpa bahan tambahan lainnya dan tidak dapat menyebabkan iritasi pada kulit ketika digunakan. Pada pembuatan sabun organik sederhana ini menggunakan minyak kelapa sebagai bahan baku utama dan natrium hidroksida (NaOH) dengan penambahan kopi sebagai pengharum organik melalui reaksi saponifikasi. Metode pelaksanaan yang dilakukan dalam kegiatan ini antara lain: melakukan sosialisasi kegiatan terkait pembuatan sabun dan manfaatnya, mengisi kuisioner sebelum dan sesudah kegiatan sebagai tolak ukur keberhasilan kegiatan tersebut, melaksanakan praktik pembuatan sabun dan pengemasan sabun yang telah jadi. Melalui kegiatan tersebut terciptalah produk sabun berbahan dasar minyak kelapa melalui metode penyabunan yang sederhana. Produk ini akan memiliki nilai jual yang tinggi jika minat masyarakat terhadap produk tersebut juga tinggi
PENDAMPINGAN PEMBUATAN LAPORAN KEUANGAN SEDERHANA WARUNG KELONTONG KAMPUNG MONGGAK REMPANG
Authors: Mulyati Sri , Ukhriyawati Catur Fatchu , Hati Ravika Permata , Hasibuan Rahman
Published: November 2023

Tujuan dari pengabdian masyarakat ini adalah untuk memberikan pendampingan dan penyuluhan kepada individu/pengusaha kecil khususnya usaha keluarga yang ada di Kampung Monggak Rempang tentang pengetahuan praktis dan sederhana mengenai mengelola keuangan sederhana sesuai dengan prinsip dalam manajemen keuangan. Metode pengabdian masyarakat yang digunakan adalah metode klasikal dengan pendekatan diskusi, tanya jawab, dan simulasi dengan maksud agar materi dapat diterima oleh masyarakat dengan baik. Diharapkan setelah dilakukannya program pengabdian ini, para peserta memiliki pengetahuan dan wawasan sebagai pengusaha kecil yang terampil mengelola keuangan dan juga mampu mencari peluang untuk menambah keuangan keluarga sebagai bekal untuk meningkatkan taraf hidupnya agar menjadi lebih baik.
MENGGALI ASPIRASI MASYARAKAT KOTA BALIKPAPAN TERHADAP PENGEMBANGAN EDUWISATA DALAM RANGKA PENINGKATAN PARTISIPASI PEMBANGUNAN IKN NUSANTARA
Authors: Rahmawati Rahmawati , Ulfah Yana , Zavira Audrey , Nisa Khoirun , Febryanti Ashari Dwi
Published: November 2023

Pemindahan Ibu Kota Negara ke Kalimantan Timur peluangnya sudah dirasakan oleh beberapa pelaku industri pariwisata, Grup Mesra memanfaatkan momentum mega proyek yang sedang intensif dilakukan semenjak awal tahun. Pemindahan Ibu Kota Negara selain membawa peluang juga membawa tantangan bagi masyarakat Kalimantan Timur, apabila masyarakat tidak secara proaktif memanfaatkan momentum pembangunan IKN Nusantara tersebut kemungkinan besar hanya menjadi penonton nantinya. Tujuan kegiatan Pengabdian Kepada Masyarakat ini untuk meningkatkan kesadaran peran masyarakat dengan adanya pemindahan IKN Nusantara dan dapat mengambil bagian dalam pengembangan produk pariwisata. Kegiatan PKM ini menggunakan metode pendekatan kualitatif. Sasaran dalam kegiatan ini adalah masyarakat di sekitar wilayah IKN Nusantara dengan total 46 orang pada tiga kelurahan di Balikpapan, yaitu Kelurahan Batu Ampar, Kelurahan Muara Rapak, dan Kelurahan Karang Joang. Adanya keterlibatan dari masyarakat maka kesempatan lapangan kerja di destinasi eduwisata dapat terbuka serta mampu meningkatkan taraf ekonomi masyarakat sekitar. Apabila destinasi eduwisata IKN mampu menarik minat wisatawan dalam skala besar, tentu akan memunculkan berbagai macam kekhawatiran. Beberapa risiko yang akan muncul diantaranya yaitu, value yang ditawarkan eduwisata tidak sesuai harapan, adanya kemacetan akibat mobilitas padat di sekitar destinasi, serta adanya risiko polusi dan kerusakan lingkungan.
Balanophoraceae e Velloziaceae, dois novos registros para Vitória da Conquista, Bahia
Authors: Caires Claudenir Simões , Santos Alessandra dos Anjos , Soares Gabriel Chaves
Published: November 2023

São apresentadas duas novas ocorrências para a flora de Vitória da Conquista, Bahia, Brasil: Barbacenia aff. bahiana L.B. Sm. (Velloziaceae) e Langsdorffia hypogaea Mart. (Balanophoraceae), sendo estes os primeiros registros para ambas as famílias no município. Barbacenia aff. bahiana foi registrada fora de área de proteção ambiental em afloramento rochoso ao longo do riacho Jurema no Distrito de Pradoso. Langsdorffia hypogaea foi encontrada em uma área com pequenos arbustos e muita serapilheira no Parque Municipal da Serra do Periperi. Ambas as localidades apresentam forte ação antrópica, no Jurema a extração por rochas do afloramento e na Serra do Periperi as invasões e loteamentos irregulares estão causando forte impacto ambiental.
Analisis Pembangkit Listrik Tenaga Surya (PLTS) Sistem On - Grid Untuk Memenuhi Kebutuhan Listrik Base Transceiver Station (BTS) di Desa Sabi Samukop Kepulauan Mentawai
Authors: Sakeru Riyan siyentanu mareat , Silalahi Eva Magdalena , Purba Robinson
Published: November 2023

PLTS merupakan sumber energi terbarukan karena menggunakan tenaga matahari sebagai sumber energinya. Solar photovoltaic menangkap panas matahari dan mengubahnya menjadi energi listrik yang dapat disimpan dalam baterai dan juga dapat digunakan secara langsung. Sistem PLTS yang digunakan dalam penelitian ini adalah sistem hybrid on-grid, dengan memanfaatkan kelebihan energi PLTS untuk dijual ke jaringan listrik (grid) PLN. Dari hasil analisis data dan simulasi software HOMER yang telah dilakukan, diperoleh energi listrik yang dibutuhkan BTS adalah sebesar 3,96 kWh/hari dan kapasitas PLTS sebesar 1,3 kW dengan produksi energi listrik sebesar 5,06 kWh/hari. Berdasarkan skenario atau konfigurasi sistem PLTS hybrid on-grid tanpa baterai dengan nilai Net Present Cost (NPC), Rp56.948.220,00, Levelized Cost of Energy (LCOE) Rp1.144,39/kWh dan Break Even Point (BEP) tercapai setelah 3,3 tahun proyek beroperasi. Berdasarkan hasil simulasi tersebut, ditinjau dari sisi ekonomi maupun sisi energi listrik yang dihasilkan PLTS hybrid on-grid tanpa baterai, dinilai layak digunakan untuk memenuhi kebutuhan listrik BTS Desa Saibi Samukop di Kepulauan Mentawai.
Diagnostic value of stress echocardiography with exercise on a horizontal bicycle ergometer in patients with low-risk non-ST segment elevation acute coronary syndrome in a South American cohort.
Authors: Lobo Diego , Dulcey Luis , Gomez Jaime , Hernandez Carlos , Theran Juan , Caltagirone Raimondo , Amaya Maria , Bermudez Santiago , Estevez Maria , Acevedo Diego , Castillo Silvia , Arias Anderson , Blanco Edgar , Ciliberti Maria , Calderon Silvia , Gutierrez Emily , Lizcano Angie , Bacca Lizeth , Martinez Juan
Published: November 2023

Objective. To evaluate the diagnostic accuracy of exercise stress echocardiography(EchoCG) on a horizontal bicycle ergometer for the detection of obstructive coronary heart disease(oCAD) in patients with low-risk non-ST-segment elevation acute coronary syndrome(NSTEACS). Material and methods. The study included 95 patients, mean age 53 years, 58% of men hospitalized in the department of the regional vascular center with a diagnosis of NSTE-ACS were at low risk. Patients with known coronary heart disease and impaired left ventricular contractility at rest were not included. They underwent stress echocardiography on a horizontal bicycle ergometer according to standard methods of conduct and interpretation, and invasive or non-invasive coronary angiography(CAG). All values of coronary obstruction ≥70% were verified by invasive coronary angiography. The assessment of myocardial revascularization was observational in nature. Results. The result of stress echocardiography according to the criterion of impaired local contractility(ILC) was positive in 16%, negative in 28%, incomplete symptom-limited in 35% patients. Coronary artery stenosis ≥50%/≥70% was detected in 78/78% of cases in the subgroup with a positive result, in 29/11% with a negative result, 30/10% with a non-diagnostic result. The association of NLS with stenosis ≥70% was higher odds ratio 30.1vs8.5 for stenoses ≥50%. Conclusion Stress echocardiography with exercise on a horizontal bicycle ergometer in patients with low-risk NSTE-ACS is safe and feasible. The method has moderate sensitivity and high specificity and overall accuracy for identifying anatomically significant coronary artery stenoses.
Faktor-Faktor yang Mempengaruhi Kepatuhan Penggunaan Alat Pelindung Diri (APD) pada Pekerja Konstruksi di PT ”X”
Authors: Devianti Iin Cahyo , Rupiwardani Irfany , Susanto Beni Hari
Published: November 2023

ABSTRAK
Alat Pelindung Diri (APD) adalah suatu alat yang mempunyai kemampuan untuk melindungi diri yang fungsinya mengisolasi sebagian atau seluruh tubuh dari potensi bahaya di tempat kerja. Latar Belakang Terdapat faktor internal dan faktor ekternal yang dapat mempengaruhi kepatuhan penggunaan APD pada pekerja konstruksi. Penyumbang data kecelakaan terbesar ke-2 di DISNAKER Jawa Timur adalah kecelakaan kerja di Perusahaan konstruksi, hal ini disebabkan rendahnya kesadaran pekerja terhadap penggunaan alat pelindung diri. Tujuan: Penelitian ini bertujuan untuk mengetahui faktor yang mempengaruhi kepatuhan. Metode: Penelitian ini menggunakan metode analitik observasional dengan pendekatan cross sectional. Populasi yang diteliti adalah seluruh pekerja konstruksi di PT. X sebanyak 200 orang, dengan jumlah sampel 67 orang. Pengambilan sampel menggunakan simple random sampling. Hasil: Dari hasil penelitian yang menggunakan analisis univariat dan multivariat didapatkan faktor masa kerja terhadap kepatuhan penggunaan APD (p-value = 0,005), pendidikan (p-value = 0.008), pengetahuan (p-value = 0.029), perilaku (p-value = 0,029), HSE inspection (p-value = 0,017), kenyamanan APD (p-value = 0,025), serta faktor yang bukan merupakan faktor yang mempengaruhi terhadap kepatuhan penggunaan APD adalah usia (p = 0,113), fasilitas K3 (p-value = 0.307 ) dan kebijakan APD (p-value = 0.783). Kesimpulan: Berdasarkan hasil penelitian dapat disimpulkan ada beberapa faktor yang mempengaruhi kepatuhan penggunaan APD pada pekerja konstruksi yaitu dari faktor internal pendidikan,pengetahuan,perilaku,HSE inspection, dan kenyamanan APD.Untuk itu disarankan perlu adanya pengawasan yang lebih tegas dan sanksi dalam penerapan pengawasan tentang kepatuhan penggunaan APD agar angka kecelakaan kerja dapat di turunkan.
Identifikasi Kepadatan Kecoa di Pelabuhan Tanjungbatu Kundur Kabupaten Karimun Provinsi Kepulauan Riau Tahun 2022
Authors: Risman  , Sapoetra Muhammad Reynaldi , Idris Muhammad Fadil , Diansafitri Mutia
Published: November 2023

Pendahuluan: Kondisi pelabuhan yang sehat dapat mencegah potensi risiko penyebaran penyakit. Kecoa merupakan salah satu vektor mekanik, yang berperan menghantarkan penyakit. Tujuan: untuk mengatahui tingkat kepadatan kecoa di Pelabuhan Kundur Kabupaten Karimun. Metode: penelitian deskriptif dengan metode survei dengan teknik pengambilan data dengan observasi di Pelabuhan Kundur, sampel penelitian seluruh  kecoa yang terperangkap dalam di dalam perangkap kecoa. Waktu penelitian selama 12 jam, dimulai dari jam 18.00 s/d 06.00 Wib. analisis kepadatan kecoa di pelabuhan jika yang memenuhi syarat dengan nilai <2 dan tidak memenuhi syarat jika nilai kepadatan kecoa  >2. Hasil: jumlah kecoa terperangkap sebanyak 15 ekor dengan 5 kali pengulangan di tempat yang sama dengan jenis kecoa yang ditemukan di Pelabuhan Tanjungbatu yaitu Periplaneta Americana. Kesimpulan: Tingkat kepadatan kecoa di pabuhan Tanjungbatu kundur berada kategori belum memenuhi syarat, perlu pengendalian dan pencegahan untuk mengurangi kepadatan kecoa dengan perbaikan sanitasi secara berkala dan penggunaan racun kecoa untuk mengurangi kepadatan kecoa.
Survei Tempat Perkembangbiakan dan Kepadatan Jentik Nyamuk Aedes sp. di Kelurahan Bastiong Talangame Kota Ternate
Authors: Mustafa  , Sidebang Purnama , Kalsum Supardi Ummi , Anjani Mahmud Nadilla
Published: November 2023

Latar Belakang: Demam berdarah tersebar luas di seluruh daerah tropis, dengan variasi risiko lokal yang dipengaruhi oleh curah hujan, suhu, dan urbanisasi. Tujuan: Untuk mengetahui tempat perkembangbiakan dan kepadatan jentik nyamuk Aedes sp. di Kelurahan Bastiong Talangame Kota Ternate. Metode: Penelitian ini merupakan penelitian deskriptif dengan desain penelitian survei dan menarasikan tempat perkembangbiakan dan kepadatan jentik nyamuk Aedes sp. Teknik pengambilan sampel yang digunakan dalam penelitian ini adalah teknik random sampling. Sampel dalam penelitian ini adalah 30 rumah yang ada di Kelurahan Bastiong Talangame Kecamatan Ternate Selatan yang diambil secara random. Hasil: Hasil penelitian menunjukkan dari jenis tempat perkembangbiakan jentik nyamuk Aedes sp. didalam dan di luar rumah di Kelurahan Bastiong Talangame, ditemukan di dalam rumah sebanyak 17 yang positif jentik dengan prsentase 56,7% dari pada di luar rumah sebanyak 13 yang negatif jentik dengan presentase 43,3%. House Index (HI) sebesar 56%. Container Index (CI) adalah 51,66%. Breteau Index (BI) adalah 103,33% dan angka bebas jentik (ABJ) didapatkan hasil nilai ABJ 43%. Kesimpulan: Tingkat kepadatan nyamuk Aedes sp. di Kelurahan Bastiong Talangame Kota Ternate masih tergolong dalam kepadatan yang tinggi.
A unique role for IL-13 in inducing esophageal eosinophilia through MID-1 and STAT6
Authors: Girkin Jason L. N. , Sokulsky Leon A. , Starkey Malcolm R. , Hansbro Philip M. , Foster Paul S. , Collison Adam M. , Mattes Joerg
Published: November 2023

Introduction

Eosinophilic esophagitis (EoE) is associated with allergen-driven inflammation of the esophagus and an upregulated Th2 cytokine signature. Recombinant interleukin (IL)-13 (rIL-13) administration to mice induces some of the hallmark features of EoE, including increased eotaxin expression and eosinophil recruitment. Inflammation in EoE has previously been shown to depend on the expression of TRAIL and MID-1, which reduced protein phosphatase 2A (PP2A) activity. The relationship between IL-13 and TRAIL signalling in esophageal eosinophilia is currently unknown.

Objective

To investigate the interaction between IL-13-driven eosinophil infiltration and TRAIL or MID-1 in the esophagus.

Method

We administered rIL-13 to wild type (WT), TRAIL-deficient (Tnsf10−/−) or STAT6-deficient (STAT6−/−) mice and targeted MID-1 with small interfering RNA.

Results

rIL-13 administration to mice increased TRAIL and MID-1 expression in the esophagus while reducing PP2A activity. TRAIL deficient, but not STAT6 deficient mice demonstrated increased MID-1 expression and PP2A reduction upon IL-13 challenge which correlated with eosinophil infiltration into the esophagus. Silencing MID-1 expression with siRNA completely ablated IL-13 induced eosinophil infiltration of the esophagus, restored PP2A activity, and reduced eotaxin-1 expression.

Conclusion

IL-13-driven eosinophil infiltration of the esophagus induced eosinophilia and eotaxin-1 expression in a STAT6-dependent and MID-1-dependent manner. This study highlights a novel mechanism employed by IL-13 to perpetuate eosinophil infiltration.
Enhancers dysfunction in the 3D genome of cancer cells
Authors: Della Chiara Giulia , Jiménez Carlos , Virdi Mohit , Crosetto Nicola , Bienko Magda
Published: November 2023

Eukaryotic genomes are spatially organized inside the cell nucleus, forming a threedimensional (3D) architecture that allows for spatial separation of nuclear processes and for controlled expression of genes required for cell identity specification and tissue homeostasis. Hence, it is of no surprise that mis-regulation of genome architecture through rearrangements of the linear genome sequence or epigenetic perturbations are often linked to aberrant gene expression programs in tumor cells. Increasing research efforts have shed light into the causes and consequences of alterations of 3D genome organization. In this review, we summarize the current knowledge on how 3D genome architecture is dysregulated in cancer, with a focus on enhancer highjacking events and their contribution to tumorigenesis. Studying the functional effects of genome architecture perturbations on gene expression in cancer offers a unique opportunity for a deeper understanding of tumor biology and sets the basis for the discovery of novel therapeutic targets.
Synergistic doping with Ag, CdO, and ZnO to overcome electron-hole recombination in TiO2 photocatalysis for effective water photo splitting reaction
Authors: Erfan Nehal A. , Mahmoud Mohamed S. , Kim Hak Yong , Barakat Nasser A. M.
Published: November 2023

This manuscript is dedicated to a comprehensive exploration of the multifaceted challenge of fast electron-hole recombination in titanium dioxide photocatalysis, with a primary focus on its critical role in advancing the field of water photo splitting. To address this challenge, three prominent approaches—Schottky barriers, Z-scheme systems, and type II heterojunctions—were rigorously investigated for their potential to ameliorate TiO2’s photocatalytic performance toward water photo splitting. Three distinct dopants—silver, cadmium oxide, and zinc oxide—were strategically employed. This research also delved into the dynamic interplay between these dopants, analyzing the synergetic effects that arise from binary and tertiary doping configurations. The results concluded that incorporation of Ag, CdO, and ZnO dopants effectively countered the fast electron-hole recombination problem in TiO2 NPs. Ag emerged as a critical contributor at higher temperatures, significantly enhancing photocatalytic performance. The photocatalytic system exhibited a departure from Arrhenius behavior, with an optimal temperature of 40°C. Binary doping systems, particularly those combining CdO and ZnO, demonstrated exceptional photocatalytic activity at lower temperatures. However, the ternary doping configuration involving Ag, CdO, and ZnO proved to be the most promising, surpassing many functional materials. In sum, this study offers valuable insights into how Schottky barriers, Z-scheme systems, and type II heterojunctions, in conjunction with specific dopants, can overcome the electron-hole recombination challenge in TiO2-based photocatalysis. The results underscore the potential of the proposed ternary doping system to revolutionize photocatalytic water splitting for efficient green hydrogen production, significantly advancing the field’s understanding and potential for sustainable energy applications.
Comparison of clinical outcomes of Ibutilide-guided cardioversion and direct current synchronized cardioversion after radiofrequency ablation of persistent atrial fibrillation
Authors: Liu Xing , He Yan , Gui Chun , Wen Weiming , Jiang Zhiyuan , Zhong Guoqiang , Wu Mingxing
Published: November 2023

Backgroup

Ibutilide has already been used for cardioversion of persistent atrial fibrillation (PsAF) after radiofrequency catheter ablation (RFCA). The purpose of this study was to determine the effect of Ibutilide-guided cardioversion on clinical outcomes after individualized ablation of PsAF.

Methods

From October 2020 to September 2021, consecutive patients with PsAF accepted for RFCA were prospectively enrolled. After individualized ablation including pulmonary vein isolation plus left atrial roof line ablation and personalized linear ablation based on left atrial low-voltage zones, patients were divided into the spontaneous conversion (SCV) group, direct current synchronized cardioversion (DCC) group and Ibutilide group according to different cardioversion types during ablation. The rates of freedom from atrial tachyarrhythmia (ATT) among the three groups were evaluated after follow-up.

Results

In this study, 110 patients were enrolled, including 12 patients with SCV, 50 patients receiving DCC and 48 patients receiving Ibutilide cardioversion after individualized ablation. Among the three groups, the SCV group had shorter AF duration {12 months [interquartile range (IQR) 12–16], P = 0.042} and smaller left atrial diameter (LAD) [35 mm (IQR: 33–42), P = 0.023]. A 12-month freedom from ATT rate was 83.3% in SCV group, 69.4% in DCC group, and 79.2% in Ibutilide group, respectively (Log-rank, P = 0.745). During the follow-up [17 months (IQR: 15–19)], the rate of freedom from ATT of SCV group (83.3%), and Ibutilide group (72.9%) were both higher than that of DCC group (53.1%, P = 0.042). Moreover, Kaplan–Meier analysis showed a significantly higher sinus rhythm (SR) maintenance in Ibutilide group than in DCC group (Log-rank, P = 0.041). After adjusting for risk factors of AF recurrence, the hazard ratio for AF recurrence of the DCC group with reference to the Ibutilide group was 4.10 [95% confidence interval (CI) (1.87–8.98), P < 0.001]. Furthermore, subgroup analysis showed that freedom from ATT rate in effective Ibutilide subgroup was significantly higher than noneffective Ibutilide subgroup (Log-rank, P < 0.001).

Conclusion

For the treatment of the patients with PsAF, Ibutilide-guided cardioversion after individualized RFCA may be benefit for maintenance of SR compared to conventional DCC, especially for the patients who are effective for administration of Ibutilide.
Improvement of the separation evolution law and separation position determination method of mining overburden strata
Authors: Da Yuxin , Ning Zhiyuan , Huang Zilong , Du Qirui , Liu Qi , Zhao Jinhai , Li Qinghai
Published: November 2023

In view of the shortcomings of the traditional method of determining the position of the separation layer, according to the actual movement of the pressure balance arch and the rock layer in the overburden, the concept of the triangular separation domain is proposed, and the relationship between the range of the triangular separation domain and the mining distance and the mining fracture angle is established. The calculation method of rock load is modified. By analyzing the stress mode in the pressure arch of the separation zone, the mechanical model of the deflection calculation of each rock stratum is established. Combining the triangular separation zone with the new mechanical model, the calculation model of the dynamic evolution analysis of the separation zone and the calculation model of the composite beam in the separation zone are established. The traditional method and the improved method are used to determine the separation position in an actual mining example. The field exploration proves that the results of the improved method described in this paper are more accurate. The model predicts the position of overburden separation by comparing the deflection between adjacent strata on the same horizontal contact surface, and can accurately predict the position of separation above the working face.
Pharmacoeconomic evaluation of anti-obesity drugs for chronic weight management: a systematic review of literature
Authors: Xue Yan , Zou Huimin , Ruan Zhen , Chen Xianwen , Lai Yunfeng , Yao Dongning , Ung Carolina Oi Lam , Hu Hao
Published: November 2023

Introduction

Pharmacological therapy is recommended as a second-line alternative to reverse obesity. Currently, five anti-obesity drugs (AODs) have been approved by the U.S. Food and Drug Administration (FDA) for chronic weight management. The aim of this paper is to investigate the pharmacoeconomic evaluation of AODs through a systematic review with a special focus on methodological considerations.

Methods

We searched the general and specific databases to identify the primary pharmacoeconomic evaluation of AODs.

Results

A total of 18 full-text articles and three conference abstracts were included in this review. Most of the economic assessments were still about Orlistat. And the observations we could make were consistent with the previous systematic review. A few studies were on the combined therapies (i.e. PHEN/TPM ER and NB ER) compared to different comparators, which could hardly lead to a generalized summary of the cost-effectiveness. Most recently, pharmacoeconomic evidence on the newest GLP 1 RA approved for the indication of obesity or obesity with at least one comorbidity emerged gradually. Modelling-based cost-utility analysis is the major type of assessment method. In the modelling studies, a manageable number of the key health states and the state transitions were structured to capture the disease progression. In particular, the principal structure of the decision model adopted in the three studies on the newly approved drug was nearly the same, which enables more in-depth comparisons and generalizations of the findings.

Conclusion

This study provided an up-to-date overview of the strengths and areas for improvement in the methodological design of the pharmacoeconomic evaluation of the licensed drugs for chronic weight management. Future modelling evaluations would benefit from a better understanding of the long-term weight loss effects of the current therapeutic options and the weight rebound process after the discontinuation of treatment.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022302648, identifier CRD42022302648.
Establishment of a prediction model for the impact of endometrial thickness on the day of embryo transfer on ectopic pregnancy in frozen-thawed embryo transfer cycle
Authors: Li Qiuyuan , Deng Xiyuan , Liu Ahui , Shen Haofei , Zhang Xuehong
Published: November 2023

Objective

This study aims to investigate the factors affecting the ectopic pregnancy (EP) rate in the frozen-thawed embryo transfer (FET) cycle.

Methods

This study retrospectively analyzed 5606 FET cycles, including 5496 cycles resulting in intrauterine pregnancy and 110 cycles resulting in EP. Smooth curve fitting and piece-wise linear regression were utilized to evaluate a non-linear association between endometrial thickness (EMT) and EP. Multiple logistic regression analysis was used to study the effect of EMT on the embryo transfer (ET) day and other indexes on EP rate after adjusting for confounding factors. A nomographic prediction model was employed to predict EP occurrence. The predictive efficacy of the model was assessed using the area under the receiver operating characteristic (ROC) curve (AUC), utilizing the bootstrap sampling method for internal validation.

Results

After accounting for the confounding factors, the segmented linear regression analysis indicated that the EMT inflection point was 9 mm; the EP rate significantly decreased by 28% with each additional millimeter of EMT up to 9 mm (odds ratio (OR) = 0.72; 95% confidence interval (CI), 0.53–0.99; P = 0.0412) while insignificantly decreased when the EMT was greater than 9 mm (OR = 0.91; 95% CI, 0.76–1.08; P = 0.2487). Multivariate logistic regression analysis revealed that after adjusting for confounders, EP risk significantly increased in the number of previous EPs ≥ 1 (OR = 2.29; 95% CI, 1.26–4.16; P = 0.0064) and tubal factor infertility (OR = 3.86; 95% CI, 2.06–7.24; P < 0.0001). Conversely, EP risk was significantly reduced by the increased EMT (OR = 0.84; 95% CI, 0.74–0.96; P = 0.0078) and the blastocyst transfer (OR = 0.45; 95% CI, 0.27–0.76; P = 0.0027). These variables were used as independent variables in a nomogram prediction model, resulting in an AUC of 0.685. The nomination models were internally verified using self-sampling (bootstrap sampling resampling times = 500). This validation yielded an AUC of 0.689, with a sensitivity of 0.6915 and a specificity of 0.5790. The internal validation indicated minimal fluctuations in the AUC, signifying a relatively stable model.

Conclusion

Undergoing EMT on the day of ET poses a separate EP risk in the FET cycle; to mitigate the EP incidence, the EMT should exceed 9 mm before ET. Furthermore, previous EPs and tubal factor infertility were additional factors independently increasing EP risk. Furthermore, implementing blastocyst transfer demonstrated that EP incidence was significantly reduced. Utilizing a nomogram predicting system enables EP risk evaluation before ET for individual patients, establishing a basis for devising clinical strategies for ET.
Performance analysis of water refrigerant heat pump with different configurations for high-temperature application
Authors: Wu Di , Hu Bin
Published: November 2023

Water is a promising working fluid for high-temperature heat pumps (HTHPs) with the advantages of being cheap, safe, stable, environmentally friendly, non-toxic, and non-flammable. HTHPs using water as a refrigerant not only can reduce greenhouse gas emissions in the industrial sectors by recovering waste heat but also have no adverse effect on the environment if the refrigerant leaks. This article evaluates the safety, energy, and exergy performance of six designed HTHP configurations with water refrigerant by analyzing the discharge superheat, power consumption, heating capacity, COP, and exergy efficiency—at different condensation and evaporation temperatures. The results indicated that water injection and intercooling can effectively decrease the discharge superheat to ensure safety performance. Among these systems, two-stage cycles can supply higher output temperatures and have better system performance compared to single-stage cycles at high-temperature lifts and large compression ratio conditions. The two-stage system with a flash tank (TS-FT) has the biggest heating capacity, the best COP, and the best exergy efficiency. With an evaporation temperature of 80°C and condensation temperature of 140°C, the COP is 4.14 and the exergy efficiency is 70.9% for the TS-FT. Compared with the single-stage ordinary system (SS-OS), the COP of the TS-FT has an increment of 36.6%. The exergy efficiency of the TS-FT is 19.8% higher than that of the SS-OS. Considering the aforementioned theoretical analysis, the TS-FT with the best safety, energy, and exergy performance is the optimal HTHP system with water refrigerant for high-temperature applications.
Automated extraction of speech and turn-taking parameters in autism allows for diagnostic classification using a multivariable prediction model
Authors: Plank I. S. , Koehler J. C. , Nelson A. M. , Koutsouleris N. , Falter-Wagner C. M.
Published: November 2023

Autism spectrum disorder (ASD) is diagnosed on the basis of speech and communication differences, amongst other symptoms. Since conversations are essential for building connections with others, it is important to understand the exact nature of differences between autistic and non-autistic verbal behaviour and evaluate the potential of these differences for diagnostics. In this study, we recorded dyadic conversations and used automated extraction of speech and interactional turn-taking features of 54 non-autistic and 26 autistic participants. The extracted speech and turn-taking parameters showed high potential as a diagnostic marker. A linear support vector machine was able to predict the dyad type with 76.2% balanced accuracy (sensitivity: 73.8%, specificity: 78.6%), suggesting that digitally assisted diagnostics could significantly enhance the current clinical diagnostic process due to their objectivity and scalability. In group comparisons on the individual and dyadic level, we found that autistic interaction partners talked slower and in a more monotonous manner than non-autistic interaction partners and that mixed dyads consisting of an autistic and a non-autistic participant had increased periods of silence, and the intensity, i.e. loudness, of their speech was more synchronous.
A descriptive study on oral hygiene practice and caries increment in children with growth stunting
Authors: Putri Tri Nugrahaeni , Indriyanti Ratna , Setiawan Arlette Suzy
Published: November 2023

Introduction

Stunting is a condition of malnutrition in children from the womb to the early life stage that causes growth failure in the body and brain. Stunting influences the development and integrity of the oral cavity and increases the risk of developing diseases in the oral cavity, such as dental caries. The growth barriers in stunting children and parental knowledge can affect maintaining oral hygiene. This study aims to determine the description of oral hygiene practice and caries increment in children with growth stunting.

Methods

This type of research is a quantitative descriptive with a Secondary Data Analysis approach in the form of examination results for the presence or absence of caries through the ICDAS index and the results of the oral hygiene practice questionnaire on 113 children with growth stunting in Sukajadi district, Bandung.

Results

Most stunting children (60.2%) experienced increased caries rates classified as low, and 70.8% had poor oral hygiene practices. There were 50 children (44.3%) with poor oral hygiene practice with low caries increment, while 18 children (15.9%) had good oral hygiene practice with low caries increment.

Conclusion

Oral hygiene practice is classified as poor, but caries increment is still relatively low in most stunting children in Sukajadi district, Bandung.
Sclerobanding in the treatment of second and third degree hemorrhoidal disease in high risk patients on antiplatelet/anticoagulant therapy without suspension: a pilot study
Authors: Pata Francesco , Bracchitta Luigi M. , Nardo Bruno , Gallo Gaetano , D’Ambrosio Giancarlo , Bracchitta Salvatore
Published: November 2023

Introduction

Around 20% of population in western countries is under anticoagulant treatment. However, there is paucity of evidence about the treatment of HD in patients under anticoagulant/antiplatelet therapy, although both suspension and continuation in the perioperative period may increase the risk of severe complications. The aim of this pilot study was to confirm the feasibility and safety of sclerobanding (Combined Rubber Band Ligation with 3% Polidocanol Foam Sclerotherapy), an office-based procedure, for the treatment of second-and third-degree HD in patients under anticoagulant/antiplatelet therapy without suspension.

Materials and methods

Patients affected by second-third-degree haemorrhoids unresponsive to conservative treatment and under anticoagulant/antiplatelet were enrolled between November 2019 and October 2021. Postoperative complications, readmission, mortality and reintervention during the follow-up were evaluated.

Results

Fifty-one patients were recruited, 23 female (45.1%) and 28 male (54.9%), with an average age of 65 years ± 11.4 SD (range 42–90). Twenty-seven patients (52.9%) had II-degree haemorrhoidal disease, and 24 (47.1%) had grade III-degree. The most frequently taken medications were dual antiplatelet therapy (51%) and new oral anticoagulants (NOACs) (21.6%). The mean follow-up was 23 months. No intraoperative complications were recorded. The rate of complications in the first postoperative month was 13.7%, represented by mild complications: 6 cases of moderate to severe pain and 1 case (2%) of thrombosis of a residual haemorrhoidal nodule, all regressing after conservative therapy. No severe complications were reported. Postoperative complications were not statistically significantly associated with the number of nodules treated (1, 2, or 3), the disease grade (2nd vs. 3rd) or the specific anticoagulant/antiplatelet regimen. During follow-up, 2 patients (4%) required a new procedure for recurrent bleeding: one an infrared photocoagulation as outpatient, and another a haemorrhoidectomy after 3 months. No cases of intraoperative or postoperative mortality occurred.

Conclusions

Sclerobanding is a safe and effective technique in treating intermediate-grade haemorrhoidal disease in patients at high risk on anticoagulant/antiplatelet therapy. Sclerobanding is repeatable, usually does not require anaesthesia, and is cost-effective. Observational multicentre studies with a larger number of patients and controlled clinical trials will be needed to confirm these results.
Agricultural Engineering Technologies in the Control of Frost Damage in Permanent Plantations
Authors: Tadić Vjekoslav , Gligorević Kosta , Mileusnić Zoran , Miodragović Rajko , Hajmiler Marko , Radočaj Dorijan
Published: November 2023

The occurrence of late spring frosts due to climate change causes great damage to plantation production worldwide. The main objective of the paper is to provide a comprehensive overview of the problem and to outline effective protective measures against late spring frosts. The nature of frost depends on regional, altitudinal, and geographic differences, but they all share a common problem: they remove heat, resulting in the freezing of new plant growth and flowers. Tissue freezing is affected by critical temperatures and the frost type, intensity, and duration. Protection against late spring frosts can be broadly divided into three categories: active, passive, and chemical measures. In the field of agricultural engineering, various techniques have been thoroughly researched, and their effectiveness has been confirmed by research. These include various sprinkler systems, different heating devices, and large-diameter fans. Conclusive findings are being made on the performance of these systems in sub-zero temperatures and their cost-effectiveness. Climate change increases the importance of protecting permanent crops from late spring frosts and requires advances in agricultural technology to meet changing production demands and challenges.
Schwarzschild Black Holes in Extended Spacetime with Two Time Dimensions
Authors: Paiman Mechid , Cornean Horia , Köhn Christoph
Published: November 2023

Black holes are one of the most extreme phenomena in the Universe, bridging the gap between the realms of general relativity and quantum physics. Any matter that crosses the event horizon moves towards the core of the black hole, creating a singularity with infinite mass density—a phenomenon that cannot be comprehended within present theories of relativity and quantum physics. In this study, we undertake an investigation of non-rotating, non-charged Schwarzschild black holes in an extended spacetime framework with two time dimensions. To accomplish this, we extend Einstein’s field equations by one more temporal dimension. We solve the corresponding equations for a spherical central mass, which leads to an Abel-type equation for the 5D Schwarzschild metric. By exploring distinct solution classes, we present an approximate solution for the 5D metric. Our proposed solution maintains consistency with Schwarzschild’s 4D solution. Finally, we address the central black hole singularity and demonstrate a potential breakthrough, as our solution effectively avoids the singularity quandary, providing valuable insight into the fundamental properties of black holes in this augmented framework.