bluuebunny/crossref_metadata_2025 huggingface dataset:
Calcium Signalling in Medulloblastoma: An In Silico Analysis of the Expression of Calcium Regulating Genes in Patient Samples
Authors: Maklad Ahmed , Sedeeq Mohammed , Milevskiy Michael J. G. , Azimi Iman
Published: August 2021

Dysregulation in calcium signalling is implicated in several cancer-associated processes, including cell proliferation, migration, invasion and therapy resistance. Modulators of specific calcium-regulating proteins have been proposed as promising future therapeutic agents for some cancers. Alterations in calcium signalling have been extensively studied in some cancers; however, this area of research is highly underexplored in medulloblastoma (MB), the most common paediatric malignant brain tumour. Current MB treatment modalities are not completely effective and can result in several long-lasting mental complications. Hence, new treatment strategies are needed. In this study, we sought to probe the landscape of calcium signalling regulators to uncover those most likely to be involved in MB tumours. We investigated the expression of calcium signalling regulator genes in MB patients using publicly available datasets. We stratified the expression level of these genes with MB molecular subgroups, tumour metastasis and patient survival to uncover correlations with clinical features. Of particular interest was CACNA1 genes, in which we were able to show a developmentally-driven change in expression within the cerebellum, MB’s tissue of origin, highlighting a potential influence on tumour incidence. This study lays a platform for future investigations into molecular regulators of calcium signalling in MB formation and progression.
Four New Cases of Hypomyelinating Leukodystrophy Associated with the UFM1 c.-155_-153delTCA Founder Mutation in Pediatric Patients of Roma Descent in Hungary
Authors: Szűcs Zsuzsanna , Fitala Réka , Nyuzó Ágnes Renáta , Fodor Krisztina , Czemmel Éva , Vrancsik Nóra , Bessenyei Mónika , Szabó Tamás , Szakszon Katalin , Balogh István
Published: August 2021

Ufmylation is a relatively newly discovered type of post-translational modification when the ubiquitin-fold modifier 1 (UFM1) protein is covalently attached to its target proteins in a three-step enzymatic reaction involving an E1 activating enzyme (UBA5), E2 conjugating enzyme (UFC1), and E3 ligase enzyme (UFL1). The process of ufmylation is essential for normal brain development and function in humans. Mutations in the UFM1 gene are associated with Hypomyelinating leukodystrophy type 14, presenting with global developmental delay, failure to thrive, progressive microcephaly, refractive epilepsy, and hypomyelination, with atrophy of the basal ganglia and cerebellum phenotypes. The c.-155_-153delTCA deletion in the promoter region of UFM1 is considered to be a founding mutation in the Roma population. Here we present four index patients with homozygous UFM1:c.-155_-153delTCA mutation detected by next-generation sequencing (whole genome/exome sequencing) or Sanger sequencing. This mutation may be more common in the Roma population than previously estimated, and the targeted testing of the UFM1:c.-155_-153delTCA mutation may have an indication in cases of hypomyelination and neurodegenerative clinical course in pediatric patients of Roma descent.
Alternative Splicing: A Key Mediator of Diabetic Vasculopathy
Authors: Cornelius Victoria A. , Fulton Jenna R. , Margariti Andriana
Published: August 2021

Cardiovascular disease is the leading cause of death amongst diabetic individuals. Atherosclerosis is the prominent driver of diabetic vascular complications, which is triggered by the detrimental effects of hyperglycemia and oxidative stress on the vasculature. Research has extensively shown diabetes to result in the malfunction of the endothelium, the main component of blood vessels, causing severe vascular complications. The pathogenic mechanism in which diabetes induces vascular dysfunction, however, remains largely unclear. Alternative splicing of protein coding pre-mRNAs is an essential regulatory mechanism of gene expression and is accepted to be intertwined with cellular physiology. Recently, a role for alternative splicing has arisen within vascular health, with aberrant mis-splicing having a critical role in disease development, including in atherosclerosis. This review focuses on the current knowledge of alternative splicing and the roles of alternatively spliced isoforms within the vasculature, with a particular focus on disease states. Furthermore, we explore the recent elucidation of the alternatively spliced QKI gene within vascular cell physiology and the onset of diabetic vasculopathy. Potential therapeutic strategies to restore aberrant splicing are also discussed.
A Study of the Structure of Japanese University Students’ Awareness of Long-Term Care Socialization
Authors: Peng Xuxin , Nakatani Hisae , Kakehashi Masayuki , Matsumoto Masatoshi
Published: August 2021

This study aimed to examine the structure of the awareness of long-term care socialization by focusing on the younger generation’s awareness in order to improve a sustainable long-term care system. A questionnaire that assessed personal attributes and awareness of long-term care socialization was administered. In total, the answers of 209 students (48.4%) were collected for factors related to the awareness of long-term care socialization extracted through exploratory factor analysis. Additionally, the responses 149 students (56.7%) were collected for the construct validity verified through confirmatory factor analysis. According to the exploratory factor analysis, awareness of long-term care socialization included 10 items and three factors: “care burden when caring for family”, “feelings about leaving family care to society”, and “sense of responsibility to care for family as a member of the family”. The goodness-of-fit model in the confirmatory factor analysis proved the awareness of long-term care socialization scale’s construct validity. The structure of the awareness of long-term care socialization included three factors: “care burden when caring for family”, “sense of responsibility to care for family as a member of the family”, and “feelings about leaving family care to society”. This study demonstrated the scale’s good reliability and validity.
The Feasibility of Using Machine Learning to Classify Calls to South African Emergency Dispatch Centres According to Prehospital Diagnosis, by Utilising Caller Descriptions of the Incident
Authors: Anthony Tayla , Mishra Amit Kumar , Stassen Willem , Son Jarryd
Published: August 2021

This paper presents the application of machine learning for classifying time-critical conditions namely sepsis, myocardial infarction and cardiac arrest, based off transcriptions of emergency calls from emergency services dispatch centers in South Africa. In this study we present results from the application of four multi-class classification algorithms: Support Vector Machine (SVM), Logistic Regression, Random Forest and K-Nearest Neighbor (kNN). The application of machine learning for classifying time-critical diseases may allow for earlier identification, adequate telephonic triage, and quicker response times of the appropriate cadre of emergency care personnel. The data set consisted of an original data set of 93 examples which was further expanded through the use of data augmentation. Two feature extraction techniques were investigated namely; TF-IDF and handcrafted features. The results were further improved using hyper-parameter tuning and feature selection. In our work, within the limitations of a limited data set, classification results yielded an accuracy of up to 100% when training with 10-fold cross validation, and 95% accuracy when predicted on unseen data. The results are encouraging and show that automated diagnosis based on emergency dispatch centre transcriptions is feasible. When implemented in real time, this can have multiple utilities, e.g. enabling the call-takers to take the right action with the right priority.
Remdesivir in Severe COVID-19 and Non-Invasive Ventilation: A Real-Life Experience
Authors: Simioli Francesca , Nicoletta Carmine , Valentino Maria Rosaria , Martino Maria , Annunziata Anna , Carannante Novella , Di Micco Pierpaolo , Fiorentino Giuseppe
Published: August 2021

Background: Antiviral treatment is a hot topic regarding therapy for COVID-19. Several antiviral drugs have been tested in the months since the pandemic began. Yet only Remdesivir obtained approval after first trials. The best time to administer Remdesivir is still a matter for discussion and this could also depend upon the severity of lung damage and the staging of the infection. Methods: We performed a real-life study of patients hospitalized forCOVID-19 and receiving non-invasive ventilation (NIV). In this single-center study, a 5 day course of Remdesivir was administered as compassionate use. Further therapeutic supports included antibiotics, low molecular weight heparin and steroids. Data collection included clinical signs and symptoms, gas exchange, laboratory markers of inflammation, and radiological findings. Major outcomes were de-escalation of oxygen-support requirements, clinical improvement defined by weaning from ventilation to oxygen therapy or discharge, and mortality. Adverse drug reactions were also recorded. All data were collected during hospitalization and during a 20-day follow up after treatment. Results: 51 patients were enrolled. A global clinical improvement was recorded in 22 patients (43%) at 12 days, and 36 (71%) at 20 days; in particular, at 12 days, 27 patients (53%) also had a de-escalation of oxygen-support class from a therapeutic point of view. Remdesivir use was associated with a lower hazard ratio for clinical improvement in the elderly (older than 70 years) and in subjects with more extensive lung involvement (total severity score at HRCT of more than 14). The 20-day mortality was 13%. Conclusions: Results demonstrated that Remdesivir is associated with an improvement in clinical, laboratory and radiological parameters in patients with severe COVID-19 and showed an overall mortality of 13%. We conclude that, in this cohort, Remdesivir was a beneficial add-on therapy for severe COVID-19, especially in adults with moderate lung involvement at HRCT.
Public Perceptions of COVID-19 Vaccines: Policy Implications from US Spatiotemporal Sentiment Analytics
Authors: Ali G. G. Md. Nawaz , Rahman Md. Mokhlesur , Hossain Md. Amjad , Rahman Md. Shahinoor , Paul Kamal Chandra , Thill Jean-Claude , Samuel Jim
Published: August 2021

There is a compelling and pressing need to better understand the temporal dynamics of public sentiment towards COVID-19 vaccines in the US on a national and state-wise level for facilitating appropriate public policy applications. Our analysis of social media data from early February and late March 2021 shows that, despite the overall strength of positive sentiment and despite the increasing numbers of Americans being fully vaccinated, negative sentiment towards COVID-19 vaccines still persists among segments of people who are hesitant towards the vaccine. In this study, we perform sentiment analytics on vaccine tweets, monitor changes in public sentiment over time, contrast vaccination sentiment scores with actual vaccination data from the US CDC and the Household Pulse Survey (HPS), explore the influence of maturity of Twitter user-accounts and generate geographic mapping of tweet sentiments. We observe that fear sentiment remained unchanged in populous states, whereas trust sentiment declined slightly in these same states. Changes in sentiments were more notable among less populous states in the central sections of the US. Furthermore, we leverage the emotion polarity based Public Sentiment Scenarios (PSS) framework, which was developed for COVID-19 sentiment analytics, to systematically posit implications for public policy processes with the aim of improving the positioning, messaging, and administration of vaccines. These insights are expected to contribute to policies that can expedite the vaccination program and move the nation closer to the cherished herd immunity goal.
Clinical Findings among Patients with Respiratory Symptoms Related to Moisture Damage Exposure at the Workplace—The SAMDAW Study
Authors: Nynäs Pia , Vilpas Sarkku , Kankare Elina , Karjalainen Jussi , Lehtimäki Lauri , Numminen Jura , Tikkakoski Antti , Kleemola Leenamaija , Uitti Jukka
Published: August 2021

Background: Respiratory tract symptoms are associated with workplace moisture damage (MD). The focus of this observational clinical study was patients with workplace MD-associated symptoms, to evaluate the usefulness of different clinical tests in diagnostics in secondary healthcare with a special interest in improving the differential diagnostics between asthma and laryngeal dysfunction. Methods: In patients referred because of workplace MD-associated respiratory tract symptoms, we sought to systematically assess a wide variety of clinical findings. Results: New-onset asthma was diagnosed in 30% of the study patients. Laryngeal dysfunction was found in 28% and organic laryngeal changes in 22% of the patients, and these were common among patients both with and without asthma. Most of the patients (85%) reported a runny or stuffy nose, and 11% of them had chronic rhinosinusitis. Atopy was equally as common as in the general population. Conclusions: As laryngeal changes were rather common, we recommend proper differential diagnostics with lung function testing and investigations of the larynx and its functioning, when necessary, in cases of prolonged workplace MD-associated symptoms. Chronic rhinosinusitis among these patients was not uncommon. Based on this study, allergy testing should not play a major role in the examination of these patients.
Is Time-Driven Activity-Based Costing Coming out on Top? A Comparison with Activity-Based Costing in the Health Field
Authors: Niñerola Angels , Hernández-Lara Ana-Beatriz , Sánchez-Rebull Maria-Victoria
Published: August 2021

The cost of health is a recurrent topic that has generated much research, as it affects all of society. Both public and private agents need to know the real cost of treatments, services, and products for decision-making. This article aims to compare the use and research impact of two cost systems widely used in health: ABC and TDABC, which is an evolution of ABC. For doing so, a bibliometric review in Scopus and Medline was carried out encompassing the years 2009–2019. The results show a great increase in publications using TDABC, while publications on ABC stabilized. On the other hand, the TDABC articles presented higher research impacts in traditional and alternative metrics. Articles on TDABC are more frequently cited, published in better journals, and more visible in academic social networks. The findings suggest that scholars and practitioners should focus on TDABC rather than ABC for addressing cost in health for its simplicity, projection, and research opportunities.
A Small Area Estimation Method for Investigating the Relationship between Public Perception of Drug Problems with Neighborhood Prognostics: Trends in London between 2012 and 2019
Authors: Sondhi Arun , Leidi Alessandro , Gilbert Emily
Published: August 2021

The correlation of the public’s perception of drug problems with neighborhood characteristics has rarely been studied. The aim of this study was to investigate factors that correlate with public perceptions in London boroughs using the Mayor’s Office for Policing and Crime (MOPAC) Public Attitude Survey between 2012 and 2019. A subject-specific random effect deploying a Generalized Linear Mixed Model (GLMM) using an Adaptive Gaussian Quadrature method with 10 integration points was applied. To obtain time trends across inner and outer London areas, the GLMM was fitted using a Restricted Marginal Pseudo Likelihood method. The perception of drug problems increased with statistical significance in 17 out of 32 London boroughs between 2012 and 2019. These boroughs were geographically clustered across the north of London. Levels of deprivation, as measured by the English Index of Multiple Deprivation, as well as the percentage of local population who were non-UK-born and recorded vehicle crime rates were shown to be positively associated with the public’s perception of drug problems. Conversely, recorded burglary rate was negatively associated with the public’s perception of drug problems in their area. The public are influenced in their perception of drug problems by neighborhood factors including deprivation and visible manifestations of antisocial behavior.
Impact of Income, Density, and Population Size on PM2.5 Pollutions: A Scaling Analysis of 254 Large Cities in Six Developed Countries
Authors: Kim Moon-Jung , Chang Yu-Sang , Kim Su-Min
Published: August 2021

Despite numerous studies on multiple socio-economic factors influencing urban PM2.5 pollution in China, only a few comparable studies have focused on developed countries. We analyzed the impact of three major socio-economic factors (i.e., income per capita, population density, and population size of a city) on PM2.5 concentrations for 254 cities from six developed countries. We used the Stochastic Impacts by Regression on Population, Affluence and Technology (STIRPAT) model with three separate data sets covering the period of 2001 to 2013. Each data set of 254 cities were further categorized into five subgroups of cities ranked by variable levels of income, density, and population. The results from the multivariate panel regression revealed a wide variation of coefficients. The most consistent results came from the six income coefficients, all of which met the statistical test of significance. All income coefficients except one carried negative signs, supporting the applicability of the environmental Kuznet curve. In contrast, the five density coefficients produced statistically significant positive signs, supporting the results from previous studies. However, we discovered an interesting U-shaped distribution of density coefficients across the six subgroups of cities, which may be unique to developed countries with urban pollution. The results from the population coefficients were not conclusive, which is similar to the results of previous studies. Implications from the results of this study for urban and national policy makers are discussed.
Psychological States and Training Habits during the COVID-19 Pandemic Lockdown in Spanish Basketball Athletes
Authors: Lorenzo Calvo Jorge , Granado-Peinado Miriam , de la Rubia Alfonso , Muriarte Diego , Lorenzo Alberto , Mon-López Daniel
Published: August 2021

The outbreak of the COVID-19 pandemic and the resulting restrictions designed to slow the spread of infection greatly disrupted people’s lives. The present study aimed to investigate the impact of lockdown on the psychology, training, and sleep habits of a cohort of basketball players. An online survey involving 169 professional and amateur athletes was conducted using four validated psychological questionnaires (WLEIS-S, POMS, BRS, SMS-II) and a Likert scale to measure the rating of perceived exertion (RPE) and training variables. Gender differences in fatigue (p = 0.022); friendships (p = 0.017); others’ emotional appraisal (p < 0.001); and resilience (p = 0.031) were apparent, with higher values for women in all categories bar resilience. Comparisons before and during the lockdown revealed that all participants reduced their RPE (p < 0.001); training days (p = 0.004); and training hours (p < 0.001), and experienced a decline in the quality of sleep (p < 0.001). Sleep hours (p < 0.001) increased during lockdown. The professionals and females maintained their training days (p > 0.05), while the non-professionals and males did not. Psychological states during lockdown were a predictor of the differences in training and recovery variables. In situations where training and competition are limited, it is important to develop plans to maintain physical activity, good quality sleep, and promote greater emotional management and understanding to control negative moods.
Employment Transitions and Mental Health in a Cohort of 45 Years and Older Australians
Authors: Arya Vikas , Sperandei Sandro , Spittal Matthew J. , Page Andrew
Published: August 2021

Background: This study investigated the associations between employment transitions and psychological distress among a cohort of 45 years and older Australians. Methods: This study was based on the 45 and Up Study, a large prospective cohort of participants aged 45 years and older (N = 267,153), followed up over the period 2006–2015. The risk of psychological distress was compared between various employment transitions categories by specifying an ordered logistic regression model adjusting for confounders. Results: Compared to participants who remained employed at baseline and follow-up, higher psychological distress was found among those who transitioned from being employed to unemployed (OR = 2.68, 95%CI 2.13–3.33) and to not being in the labour force or retired (OR = 2.21, 95%CI 1.85–2.62). Higher psychological distress was also evident among those who remained unemployed from baseline to follow-up (OR = 2.00, 95%CI 1.10–3.43), and those who transitioned from being retired to being unemployed (OR = 1.55, 95%CI 1.03–2.27). Conversely, lower psychological distress was found among those who transitioned from being unemployed to being employed (OR = 0.35, 95%CI 0.25–0.51). In general, lower psychological distress was found among ‘positive’ employment transitions (transitioning to being employed or retired). Conclusions: Policies focussing on re-employment in older age, as well as unemployment schemes, might be helpful in reducing psychological distress among middle- and old-age Australians.
The Comparison of Fatty Acid Composition and Lipid Quality Indices of Roach, Perch, and Pike of Lake Gusinoe (Western Transbaikalia)
Authors: Bazarsadueva Selmeg V. , Radnaeva Larisa D. , Shiretorova Valentina G. , Dylenova Elena P.
Published: August 2021

This paper describes the study of the fatty acid (FA) composition of three fish species (roach, perch, and pike) from Lake Gusinoe (western Transbaikalia). Using principal component analysis, the fatty acid composition of the studied fish species was shown to be species specific. The muscle tissue of roach, perch, and pike was found to contain high levels of polyunsaturated fatty acids (PUFA), including essential docosahexaenoic (DHA), eicosapentaenoic (EPA), and arachidonic acids. Indicators of nutritional quality based on the fatty acid composition showed that the values of the hypocholesterolemic/hypercholesterolemic (HH) ratio indices were sufficiently high. The atherogenicity (AI) and thrombogenicity (TI) indices, which are indicators for the nutritional value, were less than 1 in the studied fish. In terms of flesh lipid quality (FLQ), pike and perch had the highest proportion of total EPA + DHA. According to the obtained data for the composition of fatty acids in the muscle tissue of the studied fish from Lake Gusinoe, the anthropogenic load exerted on Lake Gusinoe has not yet statistically significantly affected the fish muscle quality.
Primary Care Professionals’ Self-Efficacy Surrounding Advance Care Planning and Its Link to Sociodemographics, Background and Perceptions: A Cross-Sectional Study
Authors: Lasmarías Cristina , Aradilla-Herrero Amor , Esquinas Cristina , Santaeugènia Sebastià , Cegri Francisco , Limón Esther , Subirana-Casacuberta Mireia
Published: August 2021

Primary care (PC) professionals have been considered the most appropriate practitioners for leading Advance care planning (ACP) processes with advanced chronic patients. Aim: To explore how PC doctors’ and nurses’ self-efficacy surrounding ACP is linked to their sociodemographic characteristics, background and perceptions of ACP practices. Methods: A cross-sectional study was performed. Sociodemographics, background and perceptions about ACP in practice were collected using an online survey. The Advance Care Planning Self-Efficacy Spanish (ACP-SEs) scale was used for the self-efficacy measurement. Statistical analysis: Bivariate, multivariate and backward stepwise logistic regression analyses were performed to identify variables independently related to a higher score on the ACP-SEs. Results: N = 465 participants, 70.04% doctors, 81.47% female. The participants had a mean age of 46.45 years and 66.16% had spent >15 years in their current practice. The logistic regression model showed that scoring ≤ 75 on the ACP-SEs was related to a higher score on feeling sufficiently trained, having participated in ACP processes, perceiving that ACP facilitates knowledge of preferences and values, and perceiving that ACP improves patients’ quality of life. Conclusion: Professionals with previous background and those who have a positive perception of ACP are more likely to feel able to carry out ACP processes with patients.
Surrounded by Sound: The Impact of Tinnitus on Musicians
Authors: Burns-O’Connell Georgina , Stockdale David , Cassidy Oscar , Knowles Victoria , Hoare Derek J.
Published: August 2021

AIM: To investigate the impact of tinnitus on professional musicians in the UK. BACKGROUND: Tinnitus is the experience of sound when an external source is absent, primarily associated with the ageing process, hearing loss, and noise exposure. Amongst populations exposed to industrial noise, noise exposure and noise-induced hearing loss (NIHL) have been found to be the factors most associated with tinnitus. The risk of NIHL amongst professional musicians is greater than that amongst the general population, meaning they may be at increased risk of tinnitus. METHODS: Seventy-four professional musicians completed an online survey involving closed and open-ended questions, and completed the Tinnitus fuctional Index (TFI) questionnaire. Descriptive statistics and thematic analysis of open-ended qualitative responses were used to analyse the data. RESULTS: Three themes were generated from the analysis of the responses to the open-ended questions. These themes were: (1) the impact of tinnitus on the lives of professional musicians, (2) professional musician experience of tinnitus services, support, and hearing health and safety, and (3) the support professional musicians want. The mean global TFI score for professional musicians was 39.05, interpreted as tinnitus being a moderate problem. Comparisons with general population data revealed lower TFI scores for the TFI subscales of ‘sense of control’ and ‘intrusiveness’ for professional musicians and higher for auditory difficulties associated with tinnitus amongst professional musicians. CONCLUSION: Tinnitus can negatively impact on professional musicians’ lives. There is a need for bespoke self-help groups, awareness raising, and education to prevent tinnitus and promote hearing health among musicians.
Assessment of Sound Source Tracking Using Multiple Drones Equipped with Multiple Microphone Arrays
Authors: Yamada Taiki , Itoyama Katsutoshi , Nishida Kenji , Nakadai Kazuhiro
Published: August 2021

Drone audition techniques are helpful for listening to target sound sources from the sky, which can be used for human searching tasks in disaster sites. Among many techniques required for drone audition, sound source tracking is an essential technique, and thus several tracking methods have been proposed. Authors have also proposed a sound source tracking method that utilizes multiple microphone arrays to obtain the likelihood distribution of the sound source locations. These methods have been demonstrated in benchmark experiments. However, the performance against various sound sources with different distances and signal-to-noise ratios (SNRs) has been less evaluated. Since drone audition often needs to listen to distant sound sources and the input acoustic signal generally has a low SNR due to drone noise, making a performance assessment against source distance and SNR is essential. Therefore, this paper presents a concrete evaluation of sound source tracking methods using numerical simulation, focusing on various source distances and SNRs. The simulated results captured how the tracking performance will change when the sound source distance and SNR change. The proposed approach based on location distribution estimation tended to be more robust against distance increase, while existing approaches based on directional estimation tended to be more robust against decreasing SNR.
An Analysis of the Impact of the Emissions Trading System on the Green Total Factor Productivity Based on the Spatial Difference-in-Differences Approach: The Case of China
Authors: Wang Susheng , Chen Gang , Han Xue
Published: August 2021

How to effectively identify the spatial effect of the emissions trading system(ETS) on urban green total factor productivity(GTFP) generated through the linkage of economic factors between cities is a necessary part of scientifically evaluating the effect of ETS policy in emerging- market countries. This study aims to examine the spatial effect, mechanism, and heterogeneity of the ETS on urban GTFP based on the panel data of 281 cities from 2004 to 2017 in China, applying spatial difference-in-differences(DID) Durbin model (SDID-SDM) with multidimensional fixed effect (FE). The results show that ETS significantly improves the GTFP of the pilot cities, produces a spatial spillover effect and the results are robust to the placebo test, propensity score matching SDID (PSM-SDID) test, and Carbon-ETS interference test. Further analysis shows that the policy effect is mainly driven by improving energy efficiency, promoting green innovation, and optimizing the industrial structure. In addition, we found that ETS performs better in regions with a high degree of marketization, strong environmental law enforcement, and a low proportion of coal consumption. In general, the identification method of this study can be used as a scientific reference for conducting similar research in other emerging countries.
Interaction of Impulsivity, Attention, and Intelligence in Early Adolescents Born Preterm without Sequelae
Authors: Galán-Megías Rocío , Lanzarote-Fernández María Dolores , Casanovas-Lax Javier , Padilla-Muñoz Eva María
Published: August 2021

There is insufficient evidence on the intellectual and attentional profile of adolescents born prematurely. Aim: to identify maladjustment in intellectual and attention skills at the beginning of secondary school. Method: 69 premature 12-year-old adolescents were evaluated with the WISC, d2 Test of Attention, and Test of Perception of Differences-Revised (CARAS-R). Results: adolescents present intellectual and attention abilities in the normal range. However, all premature adolescents show difficulties in impulse control and female adolescents are better in processing speed. Depending on the category of prematurity, differences in attention skills are evident. Conclusion: adolescents born prematurely without associated sequelae have significantly lower performance in the same areas than the normative group. This could affect the cognitive control of their behavior and academic performance in the medium and long term. Great prematurity could interfere with attention skills and self-control even at the age of 12, especially in males.
The Prevalence of Limited Health Literacy and Its Associated Factors among Elderly Patients Attending an Urban Academic Primary Care Clinic in Malaysia
Authors: Abd-Rahim Siti Nur Hidayah , Mohamed-Yassin Mohamed-Syarif , Abdul-Razak Suraya , Isa Mohamad Rodi , Baharudin Noorhida
Published: August 2021

Limited health literacy (HL) is linked to many negative health outcomes, including poor self-management of chronic diseases and medication adherence among patients. There are a lack of data regarding HL in the elderly population in Malaysia. This study aimed to determine the prevalence of limited HL levels and its associated factors among elderly patients in an urban academic primary care clinic in Selangor, Malaysia. A cross-sectional study was conducted among 413 elderly patients (≥60 years old) who attended this academic primary care clinic between January 2020 and January 2021. Sociodemographic data, clinical characteristics, and health literacy scores were collected. Descriptive statistics (median with interquartile ranges (IQR), frequency, and percentages) and multiple logistic regression were utilized. The prevalence of limited HL in our population was 19.1% (95% CI: 15.3, 23). The middle-old (70–79 years) and very-old (≥80 years) age groups were more likely to have limited HL (aOR 4.05; 95% CI: 2.19, 7.52 and aOR 4.36; 95% CI: 1.02, 18.63, respectively). Those with at least secondary school education (aOR 0.06; 95% CI: 0.02, 0.24) and those who found medical information via the internet/television (aOR 0.21; 95% CI: 0.05, 0.93) had lower odds of having limited HL. In conclusion, having limited HL levels was not common among elderly patients in this primary care clinic. Further studies involving rural and larger primary care clinics in Malaysia are required to support these findings.
Addressing Gaps for Health Systems Strengthening: A Public Perspective on Health Systems’ Response towards COVID-19
Authors: Balqis-Ali Nur Zahirah , Fun Weng Hong , Ismail Munirah , Ng Rui Jie , Jaaffar Faeiz Syezri Adzmin , Low Lee Lan
Published: August 2021

Strengthening the health systems through gaps identification is necessary to ensure sustainable improvements especially in facing a debilitating outbreak such as COVID-19. This study aims to explore public perspective on health systems’ response towards COVID-19, and to identify gaps for health systems strengthening by leveraging on WHO health systems’ building blocks. A qualitative study was conducted using open-ended questions survey among public followed by in-depth interviews with key informants. Opinions on Malaysia’s health systems response towards COVID-19 were gathered. Data were exported to NVIVO version 12 and analysed using content analysis approach. The study identified various issues on health systems’ response towards COVID-19, which were then mapped into health systems’ building blocks. The study showed the gaps were embedded among complex interactions between the health systems building blocks. The leadership and governance building block had cross-cutting effects, and all building blocks influenced service deliveries. Understanding the complexities in fostering whole-systems strengthening through a holistic measure in facing an outbreak was paramount. Applying systems thinking in addressing gaps could help addressing the complexity at a macro level, including consideration of how an action implicates other building blocks and approaching the governance effort in a more adaptive manner to develop resilient systems.
Effects of Door-to-Door Hang-Up Visits on the Use of Long-Lasting Insecticide-Treated Mosquito Nets in the Democratic Republic of the Congo: A Cluster Randomized Controlled Trial
Authors: Mankadi Paul Mansiangi , Jin Yan
Published: August 2021

Malaria accounts for 14% of child deaths in the Democratic Republic of the Congo, and one of the key interventions used to prevent malaria is to distribute insecticide-treated bednets (ITNs), especially long-lasting insecticidal nets (LLINs). The global health community and the Roll Back Malaria initiative have been struggling to achieve universal health coverage using ITNs, and recent studies have reported mixed results about the effects of door-to-door visits and mass distribution campaigns. We aimed to compare LLIN use for those provided by door-to-door hang-up visits and by conventional fixed distribution from distribution centers accompanied by a mass distribution campaign. A cluster randomized control trial was conducted in rural areas of Maniema Province, Democratic Republic of the Congo (DR Congo). Cross-sectional surveys were conducted on 2120 and 2156 households, respectively, with at least one child aged less than five in 76 villages. We assessed the effectiveness of door-to-door hang-up visits on the use of LLINs by exploring the interaction between the “intervention group” and “time” using generalized estimating equation models. Increased LLINs use was observed in all age groups in both arms, but usage differences were not significantly different (relative risk (RR) of LLINs use among children < 5 in the intervention group versus the control group after adjusted for clustering: 1.06, 95% CI: 0.85–1.33). We conclude that the door-to-door hang-up visits are not sufficient to persuade individuals (pregnant woman, children < 5, or all study participants) to use LLINs, although it did appear to be effective for the youngest children in the household.
Optimization of a Sports Activity Development Model Using Artificial Intelligence under New Curriculum Reform
Authors: Liu Taofeng , Wilczyńska Dominika , Lipowski Mariusz , Zhao Zijian
Published: August 2021

The recent curriculum reform in China puts forward higher requirements for the development of physical education. In order to further improve students’ physical quality and motor skills, the traditional model was improved to address the lack of accuracy in motion recognition and detection of physical condition so as to assist teachers to improve students’ physical quality. First, the physical education teaching activities required by the new curriculum reform were studied with regard to the actual needs of China’s current social, political, and economic development; next, the application of artificial intelligence technology to physical education teaching activities was proposed; and finally, deep learning technology was studied and a human movement recognition model based on a long short-term memory (LSTM) neural network was established to identify the movement state of students in physical education teaching activities. The designed model includes three components: data acquisition, data calculation, and data visualization. The functions of each layer were introduced; then, the intelligent wearable system was adopted to detect the status of students and a feedback system was established to assist teaching; and finally, the dataset was constructed to train and test the designed model. The experimental results demonstrate that the recognition accuracy and loss value of the training model meet the practical requirements; in the algorithm test, the motion recognition accuracy of the designed model for different subjects was greater than 97.5%. Compared with the traditional human motion recognition algorithm, the designed model had a better recognition effect. Hence, the designed model can meet the actual needs of physical education. This exploration provides a new perspective for promoting the intelligent development of physical education.
Gender Identity Milestones, Minority Stress and Mental Health in Three Generational Cohorts of Italian Binary and Nonbinary Transgender People
Authors: Scandurra Cristiano , Carbone Agostino , Baiocco Roberto , Mezzalira Selene , Maldonato Nelson Mauro , Bochicchio Vincenzo
Published: August 2021

Transgender and gender nonconforming (TGNC) people experience high rates of minority stress and associated risk for negative health outcomes. However, during the last years, significant positive socio-cultural changes have happened, and younger cohorts of TGNC individuals are having diverse experiences compared to older cohorts. By integrating the minority stress theory and the life course perspective, this cross-sectional, web-based study aimed to explore in 197 Italian TGNC people aged 18 to 54 years (M = 29.82, SD = 9.64) whether the average ages of gender identity milestones (i.e., first insights about being TGNC, self-labeling as a TGNC person, and coming out), minority stress, and mental health vary among three generational cohorts (i.e., Generation Z, Millennials, and Generation X). Compared with older cohorts, younger participants: (a) were more likely to be in the trans-masculine spectrum; (b) self-labeled as TGNC and came out earlier; (c) had more negative expectations and lower levels of disclosure; and (d) had higher levels of mental health problems. No generational differences related to first insights about being TGNC and distal minority stressors were found. Furthermore, compared with binary individuals, participants with a non-binary identity: (a) reported later ages for the gender identity milestones; (b) had higher negative expectations; and (c) had higher levels of mental health problems. Overall, our findings indicated that changes in the social environments have a limited impact on stigmatization processes and mental health of Italian TGNC people.
Potential Protection of Pre-Existent Antibodies to Human Coronavirus 229E on COVID-19 Severity
Authors: Guzmán-Martínez Oscar , Guardado Kathia , Varela-Cardoso Miguel , Trujillo-Rivera Alejandro , Gómez-Ñañez Iván , Ortiz-León María Cristina , Espinosa Rafaela , Ramos Celso , Pérez-Carreón Julio Isael , López-Guerrero Delia Vanesa , Sampieri Clara Luz , Alanís-García Adrián Baruch , Rojas-Durán Fausto , Zenteno-Cuevas Roberto , Gutiérrez Michelle , Montero Hilda
Published: August 2021

The causes of the broad spectrum of severity in COVID-19 are unknown. A protective effect through humoral immunity from previous infections by viruses of the SARS-CoV-2 family could explain a mild form of this disease. This study aimed to address whether the presence of antibodies against human seasonal coronaviruses (HCoVs) could prevent severe manifestations of COVID-19. A cross-sectional study was carried out in 165 participants. The presence of pre-existent antibodies against the seasonal HCoV-OC43, HCoV-HKU1, HCoV-229E, and HCoV-NL63 were detected. From all of the seasonal HCoVs studied, it was only found that being seropositive to HCoV-229E presented an association (p = 0.012) with developing mild clinical symptoms of COVID-19 or being asymptomatic. Multinomial regression analysis showed that being seropositive to HCoV-229E is associated with mild or moderate clinical symptoms for COVID-19. Statistical analysis also showed that being female is associated with being asymptomatic for SARS-CoV-2 infection or developing mild COVID-19. A subgroup analysis taking only seropositive to HCoV-229E revealed that females are more likely to develop asymptomatic SARS-CoV-2 infection (OR = 27.242, 95% CI 2.092–354.706, p = 0.012). Our results suggest that previous infections by HCoV-229E could prevent more serious clinical manifestations of COVID-19, but these are not the only variables that influence this event.
Effectiveness of Ready-to-Use Therapeutic Food in Improving the Developmental Potential and Weight of Children Aged under Five with Severe Acute Malnourishment in Pakistan: A Pretest-Posttest Study
Authors: Saleem Javeria , Zakar Rubeena , Bukhari Gul Mehar Javaid , Naz Mahwish , Mushtaq Faisal , Fischer Florian
Published: August 2021

The objective of this study was to assess whether the standard therapy of ready-to-use therapeutic food in the treatment of uncomplicated severe acute malnutrition (SAM) is effective in improving developmental potential and weight gain in children aged under five years. A multicenter pretest-posttest study was conducted among 91 children aged under five with uncomplicated SAM in Pakistan. Study participants completed their eight weeks’ therapy of ready-to-use therapeutic food according to the World Health Organization’s (WHO) standard guidelines. The study outcome was the proportion of children with improved developmental potential in all domains in comparison with the pretreatment status and children gaining >15% of their baseline weight; mean weight-for-height/length z-score after completing eight weeks’ therapy of ready-to-use therapeutic food. The Denver Development Screening Tool II was used for developmental screening. Significant changes (p < 0.05) were observed for developmental status milestones in terms of gross motor, fine motor, and personal/social milestones, as well as language and global development milestones. There was a strong positive correlation (r = 0.961) between initial weight and weight at the last visit (p < 0.001). Ready-to-use therapeutic food is effective in improving development potential as well as promoting weight gain in children aged under five with uncomplicated SAM if provided according to WHO guidelines.
Trihalomethanes in Water Supply System and Water Distribution Networks
Authors: Sriboonnak Sornsiri , Induvesa Phacharapol , Wattanachira Suraphong , Rakruam Pharkphum , Siyasukh Adisak , Pumas Chayakorn , Wongrueng Aunnop , Khan Eakalak
Published: August 2021

The formation of trihalomethanes (THMs) in natural and treated water from water supply systems is an urgent research area due to the carcinogenic risk they pose. Seasonal effects and pH have captured interest as potential factors affecting THM formation in the water supply and distribution systems. We investigated THM occurrence in the water supply chain, including raw and treated water from water treatment plants (coagulation, sedimentation, sand filtration, ClO2-disinfection processes, and distribution pipelines) in the Chiang Mai municipality, particularly the educational institute area. The effects of two seasons, rainy (September–November 2019) and dry (December 2019–February 2020), acted as surrogates for the water quality profile and THM occurrence. The results showed that humic acid was the main aromatic and organic compound in all the water samples. In the raw water sample, we found a correlation between surrogate organic compounds, including SUVA and dissolved organic carbon (DOC) (R2 = 0.9878). Four species of THMs were detected, including chloroform, bromodichloromethane, dibromochloromethane, and bromoform. Chloroform was the dominant species among the THMs. The highest concentration of total THMs was 189.52 μg/L. The concentration of THMs tended to increase after chlorination when chlorine dioxide and organic compounds reacted in water. The effect of pH on the formation of TTHMs was also indicated during the study. TTHM concentrations trended lower with a pH ≤ 7 than with a pH ≥ 8 during the sampling periods. Finally, in terms of health concerns, the concentration of TTHMs was considered safe for consumption because it was below the standard (<1.0) of WHO’s Guideline Values (GVs).
Low Doses of Ketamine and Melatonin in Combination Produce Additive Antidepressant-like Effects in Mice
Authors: Estrada-Reyes Rosa , Quero-Chávez Daniel B. , Trueta Citlali , Miranda Armida , Valdés-Tovar Marcela , Alarcón-Elizalde Salvador , Oikawa-Sala Julián , Argueta Jesús , Constantino-Jonapa Luis A. , Muñoz-Estrada Jesús , Dubocovich Margarita L. , Benítez-King Gloria
Published: August 2021

Major depressive disorder is a disabling disease with the number of affected individuals increasing each year. Current antidepressant treatments take between three to six weeks to be effective with forty percent of patients being resistant to treatment, making it necessary to search for new antidepressant treatments. Ketamine, a phencyclidine hydrochloride derivative, given intravenously, induces a rapid antidepressant effect in humans. In mice, it causes increased neurogenesis and antidepressant-like effects. However, it also produces psychomimetic effects in humans and in rodents increases the locomotor activity. In contrast, melatonin, a hormone secreted by the pineal gland and synthesized in extrapineal sites, increases new neuron formation and causes antidepressant-like effects in adult rodents with no collateral effects. Here, we assessed the effects of a non-effective dose of ketamine in combination with melatonin (KET/MEL), both on neurogenesis as well as on the antidepressant-like effect in mice. Our results showed that KET/MEL combination increased neurogenesis and produced antidepressant-like effects without altering locomotor activity after both single and triple administration protocols. Our data strongly suggest that KET/MEL combination could be used to simultaneously promote neurogenesis, reverting neuronal atrophy and inducing antidepressant-like effects.