bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin D Deficiency and its Correlation with the Severity of Heart Disease in Dilated Cardiomyopathy Patients
Authors: Kuldeep Kumar Gaur , LH Ghotekar , Shubha Laxmi Margekar , Tarun Kumar , Ritu Singh
Published: June 2023

Background: Cardiomyopathy is primarily a disorder of the cardiac muscle that causes myocardial dysfunction and is not the result of disease or dysfunction of other cardiac structures, systemic arterial hypertension and valvular stenosis or regurgitation. Aim: The present study aimed to determine the prevalence of vitamin D deficiency and its correlation with the severity of heart disease in patients with dilated cardiomyopathy (DCMP). Method: 70 ECHO-proven DCMP cases were enrolled from the medicine/ cardiology department of LHMC & associated hospitals and ABVIMS & Dr. RML Hospital, New Delhi from November 2019 to October 2021. DCMP patients with ages more than 18 years who were willing to give consent and does not meet any of the exclusion criteria were enrolled in this study. Results: Mean age of idiopathic DCMP patients was 48.3 ± 15.2. There were more males 48 (69%) than females 22 (31%). The mean ejection fraction was 26.6 ± 7.3, while the mean fractional shortening was 17.6 ± 3.1. Vitamin D deficiency was observed in 90% of patients, among which 68.5% were having moderate vitamin D deficiency and 10% were having severe vitamin D deficiency. Conclusion: In our study, vitamin D levels were inversely correlated with the severity of heart disease in DCMP patients.
WHEN EUROPEANS TRAVEL: CREATION OF A POST-NATIONAL IDENTITY THROUGH TOURISM
Authors: TAŞ İlkay
Published: June 2023

By deriving from the case of the European Union, this study aims to understand how tourism contributes to the post-national identity-making process. The European Union is selected as a case of this study because European integration represents an unprecedentedly institutionalized form of inter-state collaboration in the European continent which establishes a post-national identity. As integration evolved, attachment to a common European identity became important in ensuring support for the future of integration. Tourism due to its relation to culture, heritage, and identity-making, relates to the political objective of the European Union for promoting European identity. The study adopts a qualitative research approach with a case study to reach an extensive and in-depth description of the social phenomenon of post-national identity-making. The study finds out two major roles of tourism: tourism as a fertile ground for seeding the ideas of integration, and tourism as a context for experiencing European identity.
Timanttista avointa julkaisutoimintaa
Authors: Ollinaho Ossi , Santaoja Minna
Published: June 2023

Istahdimme helteisenä kesäkuun päivänä Amurin museokorttelin rauhaan Tampereella jakamaan ajatuksia lehden toimittamisesta, hakemaan yhteistä linjaa ja suuntaamaan tulevaa. Vastaanotamme Alue ja Ympäristö -lehden jaetun päätoimittajuuden moninaisen, syvenevän ja epämääräistyvän kriisin aikana, mutta lehden suhteen toiveikkaina. Lehdelle vuonna 2022 myönnetty Vuoden tiedelehden palkinto asettaa meille, tuoreelle päätoimittajaparille, riman korkealle, mutta tuo myös oikeutuksen ja taloudellisia mahdollisuuksia kehittää lehteä entisestään. Aikaisempien toimituskuntien työn varaan on tukeva rakentaa ja hyvässä porukassa toimitustyötä on sujuvaa opetella. Kiitos Ninalle erinomaisesta perehdytyksestä. Meillä on Maijan ja Iinan kanssa ilo alkaa toimittaa lehteä...
Эффективность программно-целевого и проектного подходов в решении жилищной проблемы в России
Authors: Кожевников С.А. , Патракова С.С.
Published: June 2023

В статье анализируется эффективность государственного управления в сфере решения жилищной проблемы в России. Показано, что активно применяемые программно-целевой и проектный подходы характеризуются целым рядом воспроизводящихся рисков и проблем, таких как как снижение доступности жилья вследствие роста цен на него и стагнации реальных доходов населения, неразвитость рынка индивидуального жилищного строительства и низкая доступность ипотечного кредитования для данного сегмента рынка и иные. Установлено, что в настоящее время фактически отсутствуют альтернативные ипотеке инструменты решения жилищных проблем, в том числе адаптированные для людей с низкими доходами, проживающих в небольших населенных пунктах, молодых семей. Авторы предлагают ряд мер для решения обозначенных проблем.
Effect of Sedation Strategy on the Hospital Length of Stay and ICU Length of Stay after On-Pump Cardiac Surgeries
Authors: Plechysta Yelyzaveta E. , Dubrov Serghii O.
Published: June 2023

Over the past decades, many approaches have been changed in intensive care and in anesthesiology. Most of these changes were included in the guidelines now well known as fast-track protocols (protocols for enhanced recovery after surgery). Cardiac anesthesiology was not an exception. Preoperative, intraoperative and postoperative management of the patient are the main components of these protocols, which are aimed at reducing the length of stay (LOS) of patients in the hospital and intensive care units (ICU).

The aim. To detect the relationship between the sedation strategy and the duration of the hospital LOS and the ICU LOS.

Materials and methods. This was a randomized, controlled, parallel study. We analyzed 194 patients over 18 years of age who underwent cardiac surgical treatment using artificial blood circulation. Statistical data processing was carried out on the basis of GraphPad Prism 9.0 software.

Results. According to our research, the average hospital LOS was 7.779 ± 2.844 days in the propofol group (n = 95), 7.188 ± 1.601 days in the dexmedetomidine group (n = 16). In the group where patients were sedated with a combination of drugs (n = 83), the average length of hospitalization was 5.904 ± 1.535 days. The average ICU LOS was 2.463 ± 1.090 days in the propofol group and 2.375 ± 1.360 days in the dexmedetomidine group. In the group where patients were sedated with a combination of drugs (n = 83), the average ICU LOS was 2.361 ± 0.8776 days. The hospital LOS of patients who were sedated with a combination of drugs was lower (p < 0.0001). When comparing the ICU LOS, no difference was found in all three sedation groups (p = 0.3903).

According to the analysis conducted in the propofol group, the ICU LOS was shorter in patients who did not receive vasoactive therapy (p = 0.0299). In the dexmedetomidine sedation group, no difference was found between the ICU LOS in patients with or without vasoactive support (p = 0.5289). In the group of patients who underwent sedation with a combination of drugs, the ICU LOS was shorter in the group of patients who underwent correction with vasoactive drugs (p < 0.0001).

Conclusion. Sedation with a drug combination (dexmedetomidine and propofol) may reduce hospital LOS (p < 0.0001). There was no influence of any sedation strategy on the ICU LOS (p = 0.3903). Early initiation of vasoactive support with sedative drug combination (dexmedetomidine and propofol) shortens the ICU LOS (p < 0.0001).
Predictors of Pacing-Induced Cardiomyopathy in Patients with Permanent Right Ventricular Pacing and Preserved Left Ventricular Systolic Function
Authors: Perepeka Eugene O. , Trembovetska Olena M. , Kravchuk Borys B. , Nastenko Ievgen A. , Sychyk Maryna M.
Published: June 2023

Right ventricular pacing may impair left ventricular systolic function in patients with reduced left ventricular ejection fraction (LVEF).

The aim. To determine the frequency of pacing-induced cardiomyopathy (PICM) in patients with permanent right ventricular pacing (at least 90%) and preserved LVEF (≥50%). To determine the risk factors for the occurrence of PICM.

Materials and methods. The study included 34 patients with indications for permanent ventricular pacing in whom pacemaker was implanted from 2012 to 2022 (mean follow-up period 44.97 ± 28.45 months). PICM was defined as a decrease in LVEF <45% during follow-up regardless of clinical manifestations. Risk factors for PICM were determined through univariate and multivariate regression analysis.

Results. The incidence of PICM in this study was 26% during the mean observation period of 44.9 ± 28.4 months. The mean time to the onset of PICM was 29 months in 5 out of 9 patients (55%), the time from implantation to diagnosis of PICM was less than a year. The mean LVEF and end-diastolic volume index at the time of follow-up differed significantly in the groups with and without PICM: 38.6 ± 5.9% vs. 53.5 ± 5.7% (p<0.001) and 97.9 ± 20.75 ml/m2 vs. 60.9 ± 19.32 ml/m2 (p<0.001), respectively. In the PICM group intraventricular asynchrony was 261.1 ± 61 ms vs. 146.1 ± 62.8 ms (p<0.001), interventricular asynchrony 91 ± 36.4 ms vs. 54.2 ± 22.2 ms (p = 0.014), the number of segments with reduced deformation 8.1 ± 2.6 vs. 3.91 ± 2.3 (p<0.001), global longitudinal strain –9.7 ± 2.6 % vs. –14.9 ± 3.4 % (p<0.001). At the time of the follow-up examination, the signal of sensitivity on ventricular lead in the PICM group was significantly reduced compared to patients without PICM (6.26 ± 4.02 mV vs. 11.56 ± 3.86 mV, p = 0.045). Paced QRS width in the PICM group was significantly larger (163 ± 22.7 ms vs. 150.8 ± 14.5 ms) and there were more patients with rate-adapted cardiac pacing in the PICM group: 4 (40%) vs. 2 (8%) (p = 0.0428). In multivariate regression analysis, a wider paced QRS (hazard ratio 1.09 for every 1 ms increment in QRS width, 95% confidence interval 1.01-1.17, p = 0.025) was an independent predictor of PICM. In two patients from PICM group, upgrade of pacemaker system to biventricular pacing was performed with an improvement in the left ventricular contractility: in one patient from 37% to 44%, in another from 34% to 51% in one and two month, respectively.

Conclusions. Cardiomyopathy due to right ventricular pacing tends to occur instantaneously in the first years after pacemaker implantation, rather than slowly progressing over time. A wider paced QRS complex is an independent predictor of PICM. Biventricular pacing effectively eliminates the consequences of non-physiological right ventricular pacing, improves left ventricular systolic function.
A Case of an Unusual Clinical Course of Mitral Stenosis
Authors: Vitovskyi Rostyslav M. , Isaienko Volodymyr V. , Vitovskyi Andrii R. , Satmari Olena V. , Yakovenko Inna G. , Volkova Natalia I.
Published: June 2023

Background. The stage 4 mitral stenosis is accompanied by atrial fibrillation which significantly worsens the prognosis due to the possibility of thromboembolic complications. However, sinus rhythm does not exclude the possibility of thrombosis which sometimes requires differential diagnosis with heart tumors.

The aim. To present a case of unusual thrombus formation in a patient with significant mitral stenosis on the background of sinus rhythm and describe the specifics of determining indications for surgical intervention.

Case report. Female patient K., 42 years old, who was admitted on January 12, 2023 to the National Amosov Institute of Cardiovascular Surgery, had been suffering from rheumatism for the past 20 years. In this case, the clinical course of mitral stenosis could be classified as stage 4, since there were signs of severe heart failure (shortness of breath on light exertion, peripheral edema, right-sided pleuritis, pulmonary thrombosis). However, the patient had sinus rhythm, which is more characteristic of the stage 3 mitral stenosis. The patient underwent mitral valve prosthetic surgery and removal of an unusual thrombus from the pulmonary valve cavity on January 23, 2023.

Conclusions. The course of mitral stenosis, despite its thorough study, may have unusual clinical and instrumental manifestations, which requires differential diagnosis with heart tumors and other diseases. In some cases, the mechanism of thrombus formation can be extremely unusual, which can be a subject for discussion by cardiologists.
Optical system for recording specimen deflection in bending tests
Authors:   Institute of Cosmophysical Research and Radio Wave Propagation of the Far Eastern Branch of RAS, Mishchenko M.A. , Larionov I.A. ,   Institute of Cosmophysical Research and Radio Wave Propagation of the Far Eastern Branch of RAS, Vas'kin V.A. ,   Institute of Cosmophysical Research and Radio Wave Propagation of the Far Eastern Branch of RAS
Published: June 2023

Special systems for recording deflections are used, when carrying out the works on three-point bending and destruction of specimens made of different geomaterials. The authors developed an off-contact recording system based on an available optical sensor in order to resolve this problem. The system was tested during the bending tests of various materials. The obtained system is sensitive enough and is an inexpensive analogue of such systems in the market.
A Short Fieldwork Report on the Nuba Mountains
Authors: Mekonnen Timkehet Teffera
Published: June 2023

This is a review on a fieldwork undertaken among the Nymang ethnic community residing on the legendary Nuba
Mountains of southern Kordofan, Sudan, in 2005. It is a result of participatory observation, and the view taken on
it is retrospective. The author was able to study the social and cultural life, rituals, taboos, musical traditions, and
many more, which are discussed in detail in a later book, thanks to her Sudanese hosts. The description carried
out in the writing reflects personal perspectives as a human being, a woman, and a complete stranger entering an
unknown and distant world. Indeed, it must have been one of the best experiences the author had in her nearly 3
decades of scholarly experience.
Rasgos geomorfológicos y régimen térmico del Macizo de Peña Ubiña (Montañas Cantábricas)
Authors: Gallinar Cañedo David
Published: June 2023

El Macizo de Peña Ubiña es uno de los cordales de mayor altitud del Macizo Asturiano (El Fontán sur, 2417 metros s.n.m.). Debido a su orografía verticalizada, retiene la humedad transportada por los vientos, provocando abundantes nieblas y precipitaciones que sobrepasan los 2000 mm en sus cumbres, muchas de las cuales son en forma de nieve. Se han identificado formas y procesos kársticos, fluviotorrenciales, glaciares, periglaciares y gravitacionales (relictos en unos casos y activos en otros). La acción del karst propició el desarrollo de formas de erosión como dolinas, dolinas de recubrimiento, simas y pozos nivokársticos, así como una gran diversidad de lapiaces estructurales, cubiertos y libres. El modelado glaciar, por su parte, generó formas erosivas como artesas glaciares, rocas aborregadas y cubetas glaciokársticas (estas últimas de génesis mixta, kárstica y glaciar); así como de acumulación en forma de morrenas glaciares, que permitieron identificar tres fases glaciares principales (Fase de Máxima Expansión del Hielo o MEH; Fase Interna I y II y Fase de Altitud I y II), y 20 aparatos glaciares durante la MEH, los cuales ocuparon una extensión de 5004 hectáreas. Por su parte, el régimen térmico actual se caracteriza por la abundancia de heladas, pero con un reducido número de ciclos de hielo-deshielo en el suelo. Estas condiciones favorecen el desarrollo de la crioturbación, la crioclastia, la solifluxión, los movimientos en masa rápidos y la abundancia de nieve, que tiende a permanecer entre 6-8 meses por encima de 1800 metros s.n.m.
IS EDUCATION A RIGHT OR A SERVICE IN COLOMBIA? A system for the reproduction of social inequalities
Authors: Gómez Calderón Diego Javier , Hernández-Umaña Bernardo Alfredo , Betancourt Ramírez Elkin Arturo , Fuentes Esparrell Juan Antonio
Published: June 2023

Education is still an important instrument of public policy and a cultural mechanism. However, depending on different conditions, it can be a scenario for constant exclusion in society or the promoter of social development, innovation, science, and technology. The starting question of this reflection article seeks to know how education is approached: is it a right or a service that reproduces social inequalities in Colombia? To answer this, this paper is divided into four parts. The first is a brief introduction contextualizing the identified problem. The second one presents the causes that originate the system for the reproduction of social inequalities in the education system based on two hypotheses raised by García Villegas and Gómez-Estrada. These are: i) the confrontation between liberal and conservative parties that conditions the State-Church relationship when implementing an educational model; and ii) the continuous tension between governments, teachers’ unions and university students who defend leftist political ideas. The third part contains a descriptive analysis on segregation in terms of quality and class of the national education system, which comprises early childhood education, primary education (elementary school), lower secondary and upper secondary education (middle school and high school), and post-secondary or tertiary education (higher education). Finally, conclusions and final considerations are made.
Global Problem, National Solution: An Evaluation of Global Public Goods during COVID-19
Authors: YÜKSEL Cihan
Published: June 2023

Globalist solution proposals for global public goods, which have both non-rivalry and non-excludability properties as well as cross-border externalities, emphasize collective action in the provision of these goods. However, the practice of the COVID-19 pandemic shows that the solution to such a global problem is not so global. This situation necessitates a re-evaluation of the concept of global public goods. The COVID-19 pandemic is a public bad, and efforts to combat the pandemic are an example of a public good. The global consequences of the said global public good also affected other global public goods, and these effects required the determination of priorities in the protection decisions. The policies of governments, caught between economic recession, political crises and health crises, have lagged far behind the globalist solution proposals of the global public goods theory. For this reason, the aim of the study is to determine that although the problem in the COVID-19 pandemic is global, its solution can remain at the national level and to re-evaluate the concept of global public goods within this framework. In the study, after conceptual explanations, first the externality relations between global public goods, and then the search for non-global solutions to the global COVID-19 problem (mask wars between countries, tension in international relations, disinformation processes in order not to take responsibility, the increase in distrust in international organizations, and global inequality created by patenting and pricing of vaccines) are explained.
Giyim ve Ayakkabılar Üzerinden Alınan Tehlikeli Kimyasal Vergisi Önerisi: İsveç Örneği
Authors: AKDEMİR Tuğçe
Published: June 2023

Tehlikeli kimyasal maddeler, çevre ve insan sağlığı için yüksek risk oluşturur. İnsan yaşamının her alanında yer alan ürünlerden olan giyim ve ayakkabılarda kullanılan tehlikeli kimyasallar ise, cilde zarar vermekte; tekstil liflerinden salınan tozun cilt teması, solunması veya istenmeden yutulması yoluyla tüketiciler tarafından çeşitli sağlık sorunları ile karşı karşıya kalınmaktadır. Dünya pazarı ve küresel ticaret sistemi içerisinde önemli bir paya sahip olan hazır giyim ve tekstil endüstrisi, artık teknolojik gelişmeler sayesinde ekonomik koşullara bağlı olarak kapsamlı bir dönüşüm süreci içine girmiş, tehlikeli kimyasal maddelerin kullanılmaması veya kısıtlanması yönünde birçok tedbir almaya başlayarak çeşitli yöntemler denemiştir. Bu kapsamda bir taraftan Avrupa Birliği REACH Tüzüğü, CLP Tüzüğü, Avrupa Yeşil Mutabakatı (European Green Deal) gibi birçok hususta düzenleme yaparken; diğer taraftan üye ülkeler kendi mevzuatını bu yönde güncellemeye ve değiştirmeye başlamıştır. Buna göre, Avrupa Birliği, kansere ve üreme sağlığı sorunlarına neden olduğu bilinen kimyasallara karşı tüketicilerinin sağlığını korumada önemli bir adım atmış, bu türden zararlı kimyasalların giyim, tekstil ve ayakkabılarda kullanımını sınırlandırmıştır. Kanserojen, mutajenik veya üreme için toksik olan kimyasal maddelerin, artık günlük giyim, tekstil ve ayakkabılarda belirli bir yoğunluk sınırının üzerinde kullanılamayacağına karar verilmiştir. Avrupa Birliği ülkelerinden İsveç ise “giyim ve ayakkabılar üzerinden alınan tehlikeli kimyasal vergisi” önerisi ile bu hususta yeni bir vergi uygulamasının önünü açmıştır. Söz konusu vergi, giysi ve ayakkabılarda çevreye ve insan sağlığına zararlı maddelere maruz kalma veya yayılma riskini etkin maliyet ile azaltmayı amaçlamaktadır. Gerek Avrupa Birliği gerek İsveç ulusal mevzuat dikkate alınarak hazırlanan bu çalışmada, uygulamaya konulması önerilen verginin hem şirketler ve tüketiciler nezdinde hem de sürdürülebilir çevre anlayışı doğrultusunda etkisi tartışılacaktır.
The Traditional Justice System versus Mediation from the Perspective of the Economic Analysis of Law
Authors: Castillo Lopez Jose Manuel
Published: June 2023

In recent decades, several public and private institutions have pointed out the deficiencies in the Judicial Administration in Spain and, consequently, proposals for reform have been put forward, including the establishment of alternative dispute resolutions (ADRs) that will inevitably arise between individuals and companies. Both in fact represent two ways of solving social conflicts, of doing justice, but in which the observance of the legal guarantees of citizens must the reserve of the Judicial System as a common procedure. Therefore, ADRs are not competitive mechanisms in the sense of being exclusive or alternative, but complementary, which open the possibility for companies and consumers to use extrajudicial means to resolve their conflicts. Mediation in consumer activities presents, in relation to the traditional and ordinary justice system, a series of elements that advise its use, since they can contribute to the improvement of efficiency and equity in the Judicial Administration. In addition, these advantages will increase with the incorporation of digital platforms into the administration of these procedures. Keywords: judicial administration, conflict resolution, efficiency, equity, legal security
Uso de medicamentos potencialmente inapropriados para idosos em um município do sul de Minas Gerais: estudo de prevalência
Authors: VIEIRA Liliana Batista , SILVA Simone Maria , REIS Tiago Marques , SANTANA Lívia Nascimento , DUTRA Camila Campos , REIS Adriano Max
Published: June 2023

Objetivos: analisar a frequência de utilização de medicamentos potencialmente inapropriados por idosos da atenção primária de um município do sul de Minas Gerais e determinar os fatores associados. Métodos: estudo observacional, delineamento transversal, realizado nas unidades de atenção primária à saúde de um município do sul de Minas Gerais. Os medicamentos potencialmente inapropriados por idosos foram classificados segundo os critérios American Geriatric Society /Beers 2019. Realizou-se análise descritiva compreendendo determinação de frequência absoluta e relativa e medidas de dispersão. A associação entre o uso de medicamentos potencialmente inapropriados por idosos e as variáveis independentes foi verificada por meio do Teste Qui-Quadrado de Pearson. As variáveis que se associaram ao uso medicamentos potencialmente inapropriados por idosos com valor de p<0,20 foram incluídas no modelo inicial de regressão logística múltipla. A seleção das variáveis a serem incluídas no modelo final foi definido pelo método Backward. No modelo final permaneceram as variáveis com valor de p<0,05. A magnitude da associação foi estimada pelo Odds Ratio. A adequação dos modelos finais foi avaliada pelo teste de Hosmer-Lemeshow. Resultados: Um total de 436 pacientes idosos, com 60 anos ou mais, foram incluídos no estudo. A frequência de uso de  medicamentos potencialmente inapropriados por idosos foi 47,7%. As classes de medicamentos potencialmente inapropriados por idosos mais utilizadas foram os inibidores da bomba de prótons; os benzodiazepínicos de longa ação, entre eles o clonazepam e o diazepam; e os antidepressivos amitriptilina, clomipramina, imipramine e nortriptilina. A regressão logística evidenciou associação positiva do uso de medicamentos potencialmente inapropriados por idosos por com polifarmácia, ausência de companheiro, presença em duas ou mais consultas nos últimos seis meses. Em relação à presença de medicamentos potencialmente inapropriados para idosos na Relação Municipal de Medicamentos da cidade desse estudo, foram identificados 48 medicamentos, o que corresponde a 43,6% do total de medicamentos selecionados no município. Conclusões: A frequência de utilização de medicamentos potencialmente inapropriados por idosos na atenção primária do município investigado foi elevada. O estudo pode auxiliar os profissionais de saúde de atenção primária nas tomadas de decisões, ajudando a garantir o uso seguro de medicamentos pelos idosos.
Ajuste de dose de antimicrobianos por função renal em Unidade de Terapia Intensiva adulto
Authors: ROJAS Camila Schafer , FLACH Karoline , CAMARGO Aline Lins
Published: June 2023

Objetivo: identificar a realização de ajuste de dose de antimicrobianos de acordo com a função renal em prescrições de pacientes internados em uma UTI adulto de um hospital geral do sul do Brasil. Métodos: estudo observacional, transversal retrospectivo, realizado em uma UTI adulto de um hospital geral do sul do Brasil no período de janeiro a dezembro de 2021. Foram incluídos todos os pacientes adultos com ≥48 horas de internação na UTI, clearance de creatinina (ClCr) ≤60 mL/min/1,73m2 e uso de um ou mais dos seguintes antimicrobianos: amicacina, ampicilina, ampicilina/sulbactam, cefepima, ceftazidima/avibactam, fluconazol, levofloxacino, meropenem, piperacilina/tazobactam e/ou voriconazol. A função renal foi estimada a partir da creatinina sérica usando a equação de Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) e a adequação da dose foi determinada pela comparação da prática com diretrizes específicas. Foram avaliadas variáveis sociodemográficas (sexo, idade, etnia), além da influência de possíveis determinantes, como: tempo de uso do antimicrobiano, tempo de internação, mortalidade, dentre outras. Resultados: foram incluídos 151 pacientes, totalizando 906 possibilidades de ajuste de dose de antimicrobianos por função renal. Entre as 906 possibilidades, 546 (60,3%) foram ajustadas adequadamente, 69 (7,6%) foram ajustadas inadequadamente e 291 (32,1%) não foram ajustadas. O voriconazol foi associado à maior proporção de doses não ajustadas 6/6 (100%), enquanto que a piperacilina/tazobactam foi associada a maior proporção de ajustes não preconizados na literatura 41/268 (15,3%). O fluconazol teve suas doses ajustadas adequadamente conforme a função renal em todas situações 21/21 (100%). O tempo de uso de antimicrobiano entre pacientes com ajuste de dose e aqueles tratados com a dose usual foi de 10 e 11 dias,  respectivamente (p <0,001), e o tempo de internação na UTI nos respectivos grupos foi de 14 e 18 dias (p <0,001). Conclusões: Nossos achados revelaram um percentual elevado de ajuste de dose de antimicrobianos conforme função renal para pacientes em UTI em comparação com outros estudos que avaliaram pacientes não críticos. Os dados sugerem que o envolvimento de médicos e farmacêuticos para garantir a dosagem adequada de antimicrobianos nefrotóxicos de acordo com função renal tem contribuído significativamente para desfechos mais favoráveis para o paciente.
A Novel Hybrid Decision Making Framework for Comparing Market Performance of Metaverse Crypto Assets
Authors:   University of Belgrade, Faculty of organizational sciences, Department of operations research and statistics, Belgrade Serbia, Pamucar Dragan , Biswas Sanjib ,   Decision Sciences & Operations Management, Calcutta Business School, West Bengal, India
Published: June 2023

With proliferation of smartphone usage and rapidly increasing internet access, the financial sectors has been witnessing a transformational change in the last few years, leading to the digital economy. The cryptocurrencies (digital assets) and the metaverse assets that use blockchain technology extensively have emerged as an attractive investment option to the investors. The review of the extant literature shows a scantiness of research in comparing the performance of metaverse crypto assets based on market indicators. In this regard, the current work aims to provide a framework to compare the metaverse crypto assets based on their market performance. To this end, the present paper proposes a novel hybrid framework such as Logarithmic Percentage Change driven Compromise Solution based Appraisal (LOPCCSA). To compare the alternatives the variables like return, momentum of the daily closing price, market capitalization, trading volume and risk (in terms of historical volatility realized over the study period 2022). From the result we observe that the momentum of the closing prices and volatility of the price movements hold the higher importance as derived by calculation of objective weights. Theta Network (A10) comes out as the top performer ahead of ApeCoin (A1) or MANA (A3) or Internet Computer (A6). The comparison of the results obtained by LOPCCSA with other MCDM models show considerable consistency. The sensitivity analysis indicates that LOPCCSA provides a stable solution. The present paper is a distinct attempt that shall attract the decision makers and investors to carry out a deeper and comprehensive analysis of the metaverse crypto assets in near future.
Analyzing the approach used for cleaning drug names in FAERS database
Authors: Gough Saam , Piaa Hami
Published: June 2023

Analyzing the approach used for cleaning drug names in FAERS database
FCRL1 is differentially expressed in metastasis to the brain in breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that Fc receptor-like 1, encoded by FCRL1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. FCRL1 mRNA was present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of FCRL1 in primary tumors was correlated with patient overall and recurrence-free survival. Modulation of FCRL1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
SOCIAL IMPACT OF HUMOR HABITS (CASE STUDY OF MALE SANTRI STUDENT LEVEL)
Authors: Ferdiansyah Muhammad Fikri
Published: June 2023

Humor is a feeling that arises when you get a tickling stimulus, both through listening and vision. Humor has a good impact on a person's psychological health. Humor also has an impact on society. Those who usually humor will have good social relationships because people who often humor make people around them feel comfortable. This study aims to find the social impact of humor habits among male Santri students level. This study used qualitative research methods, by conducting dormitory surveys, and interviews with Santri students level. The results showed that humor has a social impact in the form of closer friendship relationships, improving communication, and preventing conflict, serious difficulties, and conflict.
CHRDL1 is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that chordin-like 1, encoded by CHRDL1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CHRDL1 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CHRDL1 in primary tumors was correlated with overall, distant metastasis-free and recurrence-free survival. Modulation of CHRDL1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
A Brief Study on Role of Decision-Tree Analysis in Opioid Drug combinations
Authors: Oroy Kurez , Olgiz Kuzey
Published: June 2023

A Brief Study on Role of Decision-Tree Analysis in Opioid Drug combinations
Differential expression of coding and non-coding transcripts of the AQP7 gene in metastasis to the brain in human breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that aquaporin 7, encoded by AQP7, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. A pseudogene transcript of AQP7, AQP7P1, was also differentially expressed. AQP7 and AQP7P1 RNA were present at decreased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of AQP7 in primary tumors was correlated with patient distant metastasis-free survival. Modulation of coding and non-coding gene expression from the AQP7 gene may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
PERAN ORANG TUA DALAM MEMBENTUK KARAKTER ANAK
Authors: Nenoliu Rince Jefni
Published: June 2023

Peranan orang tua untuk membentuk karakter anak dalam keluarga sangatlah pentin, karena dalam keluarga seorang anak mula-mula memperoleh bimbingan dan pendidikan dari orang tuanya. Tugas orang tua adalah sebagai guru atau pendidik utama dan pertama bagi anak-anaknya dalam menumbuhkan dan mengembangkan karkter mereka. Orang tua juga harus menanamkan nilai-nilai karakter agar anak menjadi tangguh, bertangung jawab, jujur, mandiri, sopan, bertingkah laku yang baik dan benar, serta menghargai orang yang sudah lebih umur. Cara membentuk karakter yaitu dengan membiasakan anak melakukan hal-hal yang baik, memberikan contoh teladan yang baik dan menggunakan bahasa yang sopan ketika sedang berbicara didepan anak.
Modelling Art Experiences Based on the Theory of Complex Dynamical Systems
Authors: Cox Ralf F. A. , Tschacher Wolfgang , van Geert Paul
Published: June 2023

In this theoretical essay a novel modelling approach for describing people’s art experiences is introduced. The aim is to build a framework that is able to capture the context-sensitive and dynamic nature of such experiences. The notion of ‘flux of art experience’ is introduced to emphasise that it is an emergent phenomenon which remains in a continuous state of change. After a critical analysis of the predominant model architecture, based on the concept of a causal chain of components, we introduce interaction-dominant modelling as an alternative. This type of model is based on the theory of complex dynamical systems. Subsequently, two important concepts of the general theory are discussed, viz. synergetics and metastability, and how they apply to art experiences. In the last part of the essay guidelines for the empirical study of art experiences befitting the introduced modelling approach are presented, together with some example studies.
PENGARUH MEDIA PEMBELAJARAN AUDIO VISUAL TERHADAP HASIL BELAJAR SISWA
Authors: Sanjaya Vera Putri
Published: June 2023

Terkait dengan Pengaruh Media Pembelajaran Audio Visual Terhadap Hasil Belajar Siswa
Tiga padang hadis mukhtalif dan cara penyelesaiannya
Authors: ajid Nur
Published: June 2023

Hadis menurut bahasa adalah dakwah dan bentuk syiar dari nabi Muhammad SAW. untuk menyebarkan agama islam ke penjuru dunia melalui ucapannya, perbuatannya, taqrir nabi nabi Muhammad SAW. Dalam bentuk-bentuk hadis yang disandarkan dengan baginda nabi Muhammad SAW. Ada beberapa unsur yang penting dalam sebuah hadist, yaitu yang pertama sanad, rawi, dan yang terakhir yaitu matan. Dari tiga unsur tersebut muncul ilmu-ilmu. Yang mempelajari hadis merupakan bakti kita sebagai umat islam yang mencintai Rasulullah SAW.Seiring berjalannya dengan waktu, dari masa nya nabi Muhammad SAW, sahabat, tabi'in, tabi'ut tabi'in, ahli hadis, sampai masa sekarang, hadis sudah berkembang pesat. Sehingga banyak dari para perawi yang menafsirkan hadis, yang menghasilkan hadis yang memiliki berbagai macam kualitasnya, seperti; hadis shahih, hadis dhoif, hadis mukhtalif dan hadis hadis lainnya. Oleh karena itu penting bagi kita sebagai umat islam mempelajari hadis guna supaya tidak ada keliruan dalam menafsirkan hadis baginda nabi Muhammad SAW. Pada era tabin hadis banyak periwayat hadis yang meriwayat kan hadis-hadis dan menerima hadis dari para sahabat dan guru nya tanpa memilih-milih hadis yang doif hasan sohih, maka dari itu seiring perkembangan nya zama ketika era abad 4 H baru lah hadis mulai di bukukan untuk memudahkan para penghapal haldis dalam menghafal hadis, akantetapi ketika hadis pertama kali di bukukan itu belum meilih-milih hadis belum ada kalsifikasi hadis-hadis pada zaman tersebut. Pada zaman sekarang, banyak sekali hadis - hadis mukhtalif yang berkeliaran di masyarakat sehingga banyak sekali timbul pertanyaan-pertanyaan yang terkait dengan hadis mukhtalif dan bagaimana cara menyelesaiannya. Di artikel ini membahas tentang hadis-hadis mukhtalif dan metode metode penyelesaian di dalamnya
THE FRICTIONS OF NON-ALIGNED MOVEMENT FROM 1950S TILL 1980S IN CONTEXT OF SOUTH AND SOUTH EAST ASIAN COUNTRIES
Authors: Rai Venkatram
Published: June 2023

The Non-Alignment Movement, throughout its history, was plagued by internal bickering and failure to reach consensus on important issues. The movement was at times deeply divided on many issues with members taking sides. Nonalignment stance could often lead to increasing isolation in international politics. For India in critical situations like the 1962 Indo-China war, it was the United States, which provided military assistance to India, while most Nations of NAM took a neutral position. In 1971, Bangladesh liberation war, it was the Soviet assistance which provided India the means to victory.
The Graded Incomplete Letters Test (GILT): a short test to detect cortical visual loss in posterior cortical atrophy, with normative UK Biobank data
Authors: Yong Keir , Petzold Axel , Foster Paul J. , Young Alan , Bell Stephen , Leff Alex , Crutch Sebastian J , Greenwood John A
Published: June 2023

Higher order impairments of object recognition are core features of neurodegenerative syndromes, in particular posterior cortical atrophy (PCA), the ‘visual-variant of Alzheimer’s disease’. These impairments arise from damage to cortical visual regions and are often missed or misattributed to one of the more common ophthalmological conditions. Consequently, the diagnosis can be delayed for years with considerable implications for patients. Here we report a new test, the Graded Incomplete Letters Test (GILT), for rapid measurement of cortical visual loss and differentiation of ocular and cortical causes of visual loss. The GILT is an optimised psychophysical variation of a test used to diagnose cortical visual impairment which measures thresholds for recognising letters under levels of increasing visual degradation (decreasing completeness). Consistent with other ophthalmic tests like acuity or contrast sensitivity charts, thresholds are based on performance scored “by line” (cut-off thresholds) and “by letter” (letter-based thresholds). The GILT was administered to UK Biobank volunteers (total n= 2,359) and participants with neurodegenerative conditions characterised by predominant cortical visual (PCA n=10) or memory loss (typical Alzheimer’s disease n=9). Findings suggest UK Biobank participants, including those with documented ophthalmological conditions, were able to recognise letters under low levels of completeness. However, participants with PCA exhibited a particular tendency to make errors with modest decreases in completeness, while performance in participants with mostly mild, typical Alzheimer’s disease was comparable to that of the UK Biobank sample. Using letter-based thresholds for participants reaching <80% accuracy cut-off, GILT sensitivity and specificity values were 90% and 91% respectively when comparing PCA to UK Biobank participants without or with documented visual conditions (total n without=1757; n with=194). These first release UK Biobank and pilot patient data suggest the GILT is specific to cortical visual loss and PCA. The GILT may have utility in screening for visual loss owing to posterior cortical damage and differentiating cortical visual loss from common eye-related conditions.
Psychological traits associated with anabolic androgenic steroid use and dependence among female athletes
Authors: Scarth Morgan , Havnes Ingrid Amalia , Jørstad Marie Lindvik , Bjørnebekk Astrid
Published: June 2023

Background: Anabolic-androgenic steroids (AAS) are commonly taken to increase muscle size and enhance performance. However, AAS can lead to many adverse effects, including challenges with mental health and behavior. This study aims to identify behavioral and psychological correlates of AAS use and dependence among female weightlifters.Method: A sample of n=32 female weightlifters, including 16 with reported AAS use completed questionnaires including the Achenbach System of Empirically Based Assessment (ASEBA) and Buss-Perry Aggression Questionnaire (BPAQ). AAS dependence was evaluated using the Structure Clinical Interview for DSM-IV. Group comparisons were made using Welch’s t-tests between control and AAS groups, and AAS dependent and non-dependent groups. Correlations were computed between symptoms of dependence and behavioral and psychiatric scales.Results: Females who had used AAS had higher levels of both externalizing and internalizing psychopathology, as well as aggressive traits. Several ASEBA scales including antisocial, externalizing problems and ADHD were correlated with aggressive traits. The most prevalent dependence symptoms were time spent on activities surrounding AAS use (n=7, 50%), and using more or for longer than planned (n=6, 42.9%). Dependence symptoms were associated with several ASEBA scales: tolerance was correlated with aggressive behavior (ρ=0.79, p<0.001), withdrawal was correlated with attention problems (ρ=0.78, p<0.001), and being unable to quit use was associated with anxious/depressive (ρ=0.80, p<0.001) and internalizing problems (ρ=0.79, p<0.001).Conclusion: Females who currently or previously used AAS demonstrated significantly more difficulties with maladaptive functioning and aggressive traits compared to those who have never used. Attention problems may represent an underlying shared risk factor for both aggressive traits and symptoms of AAS dependence.
Comparing the Accuracy of Three Predictive Information Criteria for Bayesian Linear Multilevel Model Selection
Authors: Devine Sean , Falk Carl F. , Fujimoto Ken A.
Published: June 2023

Due in part to recent advances in software, such as Stan and the popular brms package in R, Bayesian multilevel modeling techniques have become increasingly popular. As researchers leverage these techniques to fit new models, information criteria—fit indices which provide information about a model’s fit to the data—play an important role in disambiguating between competing models. However, a systematic evaluation of these Bayesian criteria in a multilevel context has not yet been undertaken. Here, using simulation, we investigate the model selection accuracy of three popular information criteria: the deviance information criteria (DIC), Watanabe-Akaike information criterion (WAIC), and leave-one-out cross-validation information criterion (LOO-CV). We manipulated the following factors to determine how they affected these indices’ accuracy in identifying the data generation model: 1) the number of groups, 2) number of observations, 3) variance of the random effect, 4) fixed effects magnitude, 5) model misspecification, and 6) model selection strategy. In general, WAIC and LOO-CV outperformed DIC and are recommended when computationally feasible. In addition, we argue that a selection strategy that simply chooses the model with the lowest information criteria—a practice that is frequently employed in applied research—may result in overfitting. Recommendations for best practices regarding Bayesian multilevel modeling selection are provided.
Nature, Nurture, and Nous: The Role of Reflection and Reason in the Nature-Nurture Debate
Authors: Gabora Liane
Published: June 2023

Biological and social factors (i.e., nature and nurture) interact to give rise to specific human attributes; but they alone are insufficient to explain our most uniquely human attributes: our creative ideas, artifacts, and cultures, and the diverse worldviews that underlie them. We posit that these attributes stem from the capacity for an autonomous, generative stream of thought; it relies on nous. The word ‘nous’ comes from the Greeks, and refers to intellect, understanding, thought, or reason. Our abstract thoughts, ideas, and unique creative styles, and how they crystallize into distinct ways of seeing, being, and contributing to the world may seem harder to pin down or study scientifically than innate drives (nature) and socially learnt (nurture). We show how these attributes can be modelled using autocatalytic networks. Originally used to model the origin of life, autocatalytic networks provide an abstract formal framework with which to model the emergence and growth of networks; not just the networks of catalytic molecules at the core of biological evolution, but also the cognitive structures at the core of biological evolution. Applied to culture, they allow us to model the cognitive steps involved in how knowledge obtained through social or individual learning (modelled as foodset items) ‘catalyze’ the generation of new ideas and perspectives (foodset derived items), and to track lineages of cultural adaptation and change. We outline how they have bene used to model significant transitions in human cultural prehistory, as well as cognitive development in the mind of a child, and cultural discontinuities caused by cross-domain transfer.