bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Rowing on Cardiac Function in Breast Cancer Survivors
Authors: Gavala-González Juan , Real-Pérez Mateo , Gamboa-González Juan , Fernández-García José Carlos
Published: July 2024

This longitudinal study aimed to analyze the effects of a team rowing-based training program on physical fitness and anthropometric parameters in female breast cancer survivors (n=40; 56.78±6.38 years). Participants were divided into two groups: one rowed in fixed seat rowing (FSR) boats (n=20; 56.35±4.89 years) and the other in sliding seat rowing (SSR) boats (n=20; 57.20±7.7 years). Both groups engaged in two 75-minute sessions per week for 24 weeks. Significant improvements were observed in both groups in resting heart rate (FSR: -10.65 bpm; SSR: -8.45 bpm), heart rate at the beginning of the 6-minute walk test (6MWT) (FSR: -10.7 bpm; SSR: -11.25 bpm), and heart rate at the end of the test (FSR: -13.85 bpm; SSR: -20.35 bpm). Blood pressure improved significantly in both diastolic blood pressure (FSR: -12.35 mmHg; SSR: -19.25 mmHg) and systolic blood pressure (FSR: -13 mmHg; SSR: -16.95 mmHg). Additionally, both groups increased the distance covered in the 6MWT (FSR: +63.05 m; SSR: +93.65 m). These results suggest that a rowing training program is a viable and safe activity for female breast cancer survivors, improving cardiac function, blood pressure, and cardiorespiratory capacity, particularly in sliding seat boats.
Modeling and Simulation of Event Systems
Authors: Shornikov Yuri , Dostovalov Dmitry , Astapchuk Viktor , Ganelina Natalie , Timofeev Konstantin A
Published: July 2024

The advanced industrial systems are characterized by complex event-driven processes. The specification and computer analysis are illustrated by the common problem of a servo drive with the PWM controller. A mathematical model from the class of Cauchy problems with non-liner control logic is presented to resolve the task discussed. The designed model is performed in two stages: the mathematical model specification (modeling) and implementation (simulation). Two approaches to make a model specification are considered, the first one is the traditional structural technique, and the advanced method is based on the finite state machine paradigm. Structural and finite state software models are built in progressive simulation tools. Computer implementation of the software models of hybrid systems is performed using platform built-in libraries with numerical methods and algorithms for correct event detection. The results of computational experiments for transient processes of phase variables are qualitatively identical, that proves the adequacy of the developed models. The algorithm for asymptotic event detection is considered in detail. This technique demonstrated the best results by the one-sidedness criterion, which is explained by using the author’s algorithm for the integration step determining and the event function dynamics monitoring in the vicinity of the event limits.
Entrepreneurial Proficiency, Financial Knowledge and Sustainable Functioning – Examining the Mediating Role of Business Resilience among Indian Entrepreneurs
Authors: SIDDIQUI AFAQUE , ROKADE VARSHA
Published: July 2024

This study looked into how financial knowledge and entrepreneurial proficiency affected the performance of small, sustainable businesses. In parallel, we looked at how business resilience mediated the relationship between entrepreneurial proficiency and financial knowledge and long-term company success. Using an offline questionnaire, we employed a quantitative approach to gather data from 275 Indian small company owners. PLS-SEM was used to analyse the data that had been gathered. The findings show that resilience and entrepreneurial ability are very positively impacted by financial knowledge. The business resilience and sustainable performance of Indian SMEs are significantly enhanced by entrepreneurial competencies. Moreover, it was shown that business resilience moderated the influence of financial knowledge and proficiency on sustainable performance among Indian SMEs, while concurrently having a significant impact on sustainable performance. In keeping with India Vision of Viksit Bharat@2047: Crystal Gazing Through MSME Sector, which places a strong emphasis on entrepreneurship and the growth of a financially independent entrepreneurial community, this study helps to open up business options for regional business owners who oversee small businesses. According to the most recent figures (2021–2022) from the Ministry of Statistics & Programme Implementation, MSMEs make up a startling 29.15% of India’s GDP. This indicates their critical significance in the development of the country as it equates to a sizeable portion of the economic pie. In addition to adding to the corpus of knowledge, this research can help policymakers develop relevant plans to motivate SMEs that have been most negatively impacted by the COVID-19 pandemic to operate sustainably. There are also several other ramifications for financial institutions and business owners.
Interspecies Competition of Mono or Dual Species Biofilms of MDR Staphylococcus aureus and Pseudomonas aeruginosa Promotes the Killing Efficacy of Phage or Phage Cocktail
Authors: Pallavali Roja Rani , Guda Dinneswara Reddy , Degati Vijaya Lakshmi , Durbaka Vijaya Raghava Prasad , Choi Jeongdong
Published: July 2024

Staphylococcus aureus and Pseudomonas aeruginosa are opportunistic pathogens commonly associated with burn wound infections. These bacteria can form biofilm and contribute a high-level drug resistance to available antibiotics. This study focused on the bacteriolytic activity of phages vB_SAnS_SADP1 and vB_PAnP_PADP4 on 24 h old single or dual-species biofilms of Staphylococcus aureus and Pseudomonas aeruginosa in alone and in combination. Scanning and confocal laser scanning microscopic studies confirmed the structural organization of biofilms in single or dual-species combinations in in-vitro conditions. Single species biofilms are more robust and densely packed at 24 h of incubation. In contrast, dual-species biofilms (0.67± 0.02) are weakly associated due to their inter-species competition and are easily affected by phage cocktails (0.16 ± 0.02). In Invitro conditions, dual-species biofilms were more easily affected by phage cocktail than single phage. Scanning electron microscopic studies revealed the complete diminishment of biofilm formation by four h treatment with single phage or phage cocktails on single species or dual-species biofilms. Confocal laser scanning microscopic images with stains Syto®9 and propidium iodide revealed that phage treatment showed significant uptake of propidium iodide, indicating massive cell death mediated by respective phage or phage cocktail.
Absence of AQP4 Prolongs the Presence of a CD11c+ Microglial Population during Postnatal Corpus Callosum Development
Authors: Mayo Francisco , González-Vinceiro Lourdes , Hiraldo-González Laura , Calle-Castillejo Claudia , Torres-Rubio Ismael , Mayo Manuel , Ramirez-Lorca Reposo , Echevarría Miriam
Published: July 2024

Aquaporin-4 (AQP4) expression is associated with development of congenital hydrocephalus due to its structural role in the ependymal membrane. Gene expression analysis of periaqueductal tissue in AQP4-knockout (KO) mice at 11 days of age (P11) showed modification in ependymal cell adhesion and ciliary protein expression that could alter cerebrospinal fluid homeostasis. A microglial subpopulation of CD11c+ cells were overexpressed in the periaqueductal tissue of mice that did not develop hydrocephalus, suggesting a possible protective effect. Here, we verified the location of this CD11c+ expression in the corpus callosum (CC) and cerebellum of AQP4-KO mice and analysed its time course. Immunofluorescence labelling of the CD11c protein in the CC and cerebellum of WT and KO animals at P3, P5, P7 and P11 confirmed an expanded presence of these cells in both tissues of the KO animal; CD11c+ cells appeared at P3 and reached a peak at P11, whereas in the WT animal they appeared at P5, reached their peak at P7 and were undetectable by P11. The gene expression analysis in the CC samples at P11 confirmed the presence of CD11c+ microglial cells in this tissue. Among the more than 4000 overexpressed genes, Spp1 stood out with the highest differential gene expression (600), with other genes such as Gpnmb, Itgax, Cd68 and Atp6v0d2 also identified as overexpressed. Therefore, CD11c+ cells appear to be necessary for normal corpus callosum development during postnatal life, and absence of AQP4 prolonged its expression in this tissue.
Terapêutica Nutricional nas Úlceras por Pressão: uma revisão narrativa baseada na evidência
Authors: Armanda Marques Maria ,   Unidade Científico-Pedagógica de Dietética e Nutrição, Escola Superior  de Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  S. Martinho do Bispo,  3046-854 Coimbra,  Portugal, Rodrigues Claúdia , Faria Ana , Loureiro Helena ,   Unidade Científico-Pedagógica de Dietética e Nutrição, Escola Superior  de Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  S. Martinho do Bispo,  3046-854 Coimbra,  Portugal,   Unidade Científico-Pedagógica de Dietética e  Nutrição, Escola Superior  de Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  S. Martinho do Bispo,  3046-854 Coimbra,  Portugal,   Unidade Científico-Pedagógica de Dietética e  Nutrição, Escola Superior  de Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  S. Martinho do Bispo,  3046-854 Coimbra,  Portugal
Published: July 2024

A nutrição apresenta um papel fundamental na prevenção e cicatrização de úlceras por pressão. A nutrição do doente com úlceras por pressão deve ser adequada, de forma a providenciar energia e substrato suficientes, em macro e micronutrientes, para suportar as necessidades aumentadas, derivadas da presença de uma lesão cutânea. Foi realizada uma pesquisa bibliográfica nos motores busca PubMed, Google Scholar, Scopus e ISI Web of Knowledge com as palavras-chave “nutrition” e “supplementation” associadas a “pressure injuries” e “pressure wounds”. As carências nutricionais impedem o normal processo de cicatrização, pelo que, o fornecimento adequado do substrato energético-proteico é a base da terapêutica nutricional. Muitos dos estudos analisados apontam benefícios para utilização de nutrientes específicos, porém têm limitações metodológicas. No entanto, são necessários mais estudos para reforçar as recomendações nutricionais específicas. Apesar de o papel da nutrição ser reconhecido na prevenção e no tratamento das úlceras por pressão, é de extrema importância que a avaliação e intervenção nutricional sejam precoces.
Stories of Justification – Stories of Absolution: How Families in Liberec Came to Terms with Post-Displacement Heritage
Authors: Hoření Karina
Published: July 2024

The article focuses on how residents of the north Bohemian town of Liberec deal in their family histories with possession of post-displacement. The objects they use were confiscated from the German-speaking minority in the aftermath of World War 2. The text provides an overview of narratives of this event in the Czech public discourse and discusses how these are reflected in family stories. The study is based on three family histories collected during ethnographic fieldwork and the analytical framework is informed by memory studies and theories of hauntology.
HISTORICAL DEMOGRAPHY AND GENEALOGY. THEIR APPROACHES IN THE PAST AND PRESENT
Authors: Černý Václav
Published: July 2024

This study is a reflection on the possibilities for cooperation between the fields of historical demography and genealogy. The first part of the paper summarizes the development of genealogy as a discipline in the Czech context. The paper goes on to recapitulate theoretical and practical examples of the involvement of genealogy in historical-demographic research in western historiography, especially in the North American context. The paper then discusses Czech development from the 1960s to the present. The paper compares the possibilities of both approaches by introducing the creation of a database using the classical application of the method of family reconstitution, discussing its pitfalls and the characteristics of such research in the Czech context. The paper then presents the possibilities of applying genealogical approaches and evaluations the situations in which applying such approaches is most appropriate.
Excavating Intercultural Communication At Tourism Facilities Intentions To Visitor Satisfaction
Authors: Fitri Wahyu Nurul , Syam Ummi Khaerati , Sangkala Ismail , Suleymanova Nargiza
Published: July 2024

This research was conducted at one of the tourist locations, namely Ke'te Kesu', North Toraja Regency. The aim of this research are  to identify Information needs by the tourists in terms of intercultural communication and to identify the satisfaction of tourist.  As well as, creating innovations to overcome these problems for tourist satisfaction.  In the data collection process, this research uses the Design Thinking methodology stages. The four stages are (1) Sense and Sensibility, (2) Empathy, (3) Ideation and (4) Prototype. The research results show that there are difficulties in communicating due to language differences with local residents, so tourists sometimes experience confusion. Facilities at tourist locations lack safety because slippery stairs provide access for visitors to enjoy various destinations. Alternative solutions that have been provided by researchers include the Wonderful Toraja Application (WOTA) to make it easier for tourists to communicate and the Ke'te Kesu Tentacle (KeKel) to make it easier for tourists to access slippery stairs.
Analyzing Communication and Satisfaction in Mental Health Online Consults for Students
Authors: Mirawati Ira , Wirakusumah Teddy Kurnia , Rahmawan Detta
Published: July 2024

Online mental health consultation applications have become increasingly prevalent in Indonesia. Teenagers, including college students use these applications to communicate their problems and seek solutions. This study aims to describe final year students' experiences in using these applications. This study evaluates the effectiveness of an online mental health consultation service through the perceptions of 118 users, utilizing a Likert scale across three key dimensions: usefulness, usability, also integration and infrastructure. The findings indicate a generally positive reception of the service.  In the usefulness dimension, the service scored well in terms of meeting advertised expectations, maintaining consistent quality, fostering optimism, providing clarity on mental health issues, and making users feel at ease. The usability dimension highlighted the enjoyable nature of the application and its benefits, though it revealed a need for improvement in accessibility for users with disabilities. The integration and infrastructure dimension reflected positively on the service's intuitive design and user-friendliness, with high scores in data confidentiality, responsiveness of counsellors, clarity of communication, and effectiveness in addressing user issues. Users also expressed a willingness to reuse the service for future mental health needs, indicating its perceived value and reliability.
Factors Influencing Shopee Users’ Purchase Decisions: An Islamic Economics Perspective
Authors: Amijaya Rachmania Nurul Fitri
Published: July 2024

The purpose of this study is to investigate the impact of product reviews and trust on Shopee purchasing behavior from the perspective of Islamic Economics. Data was gathered via surveys and analyzed using data analysis procedures such as the validity test, reliability test, classical assumption test, multiple linear regression analysis, t-test, F test, and coefficient of determination. This study makes use of product review factors, trust variables, and purchasing decision variables. The result indicates product review and trust are significant positives to purchasing decisions. The study emphasizes the importance of product evaluations and trust in influencing shopping decisions on Shopee within the context of Islamic Economics. Recognizing the interaction of these elements may help firms, platform operators, and legislators make strategic decisions about how to create a climate conducive to internet trade while adhering to ethical and Islamic standards.
Asset Management in Islamic Inheritance: A Solution for Economic Empowerment Obstacles
Authors: Puspitasari Indah , Wahyudi Amin
Published: July 2024

If inheritance assets are transferred, the economic well-being of heirs should increase. However, conflicts among heirs often prevent this, resulting in unproductive or disputed assets with unclear ownership. These disputes significantly hinder the economic progress of the heirs. This article attempts to propose a solution to the problem. According to Islamic inheritance principle, before distribution, there are three obligations must be fulfilled: handling the body's costs, repaying the deceased's debts, and executing their will within limits. Afterward, remaining assets can be distributed among entitled heirs according to Islamic inheritance laws. The remaining assets, termed inheritance, can enhance heirs economic empowerment when distributed. The asset management approach that focuses on Islamic inheritance is expected to further impetus for the economic strengthening of individual beneficiaries specifically, as well as benefit the Muslim community and the general public in the country, such as alleviating conflicts and cultivating heightened economic activity. This qualitative study utilizes a library research approach with phenomenological lens. Based on the literature review conducted, asset management based on the principles of  Islamic heritage with the aim of increasing economic empowerment is: providing education to families about Islamic inheritance; accurately record ownership of property, debts, and receivables; the written documents as proof of ownership of asset, and the determination of inheritance rights and their division should be held; utilizing inheritance assets productively to establish sustainable individual or family finances.
The Effect of Islamic Financial Inclusion and Literacy on the Productivity of MSMEs: Case Study in Probolinggo
Authors: Rumasukun Muhammad Alfan , Maharani Alivia
Published: July 2024

Looking at the large contribution of MSMEs to GDP growth, namely 0.2%, it can be seen that the market in this sector is supported by a fairly large portion of the workforce, reaching 96.92%. However, the low productivity of MSMEs is a concern because the input produced is not commensurate with the output produced. This research aims to investigate and understand the productivity problems faced by MSMEs (Micro, Small and Medium Enterprises) in Probolinggo, especially in Mayangan sub-district. This research covers aspects such as financial inclusion and financial literacy, with a focus on sharia approaches. This was done to understand the impact of sharia financial inclusion and sharia financial literacy on the productivity of MSMEs in the region. The study employs quantitative research methods and utilizes primary data obtained from respondent-filled questionnaires. The population consists of MSMEs in the Mayangan District, with 30 respondents selected through Probability Sampling. Then the data is processed using multiple linear regression analysis techniques using the SPSS (Statistical Package for Social Sciences) program. The results of this study indicate that Islamic financial inclusion and Islamic financial literacy have a significant effect on the productivity of MSMEs. This is evidenced by the result of the coefficient of determination analysis where the variables of Islamic financial inclusion and Islamic financial literacy affect MSMEs productivity by 84,3% and the remaining 15,7% is explained by other variables not included in this study.
The neurocognitive mechanism underlying math avoidance among math anxious people
Authors: Fang Cui , jie Liu , Zhifeng Li , Jiawang Yang , Hao He
Published: July 2024

This study delves into the cognitive and neural underpinnings of math avoidance behavior in individuals with high math anxiety (HMA), a pattern that contributes to a detrimental cycle of limited practice, poor performance, heightened anxiety, and avoidance of math-related tasks.
We employed a novel experimental paradigm where participants evaluated the economic benefits against the cognitive costs of engaging in a mathematical problem-solving task. Utilizing a general linear model and Hierarchical Drift Diffusion Model regression, we found that the math avoidance tendency in HMA is primarily driven by elevated task difficulty sensitivity, rather than by changes in reward sensitivity. Task difficulty sensitivity emerges as a significant mediator between math anxiety scores and the tendency to avoid math tasks. Neurologically, we pinpointed key networks involved in math avoidance: the ventral valuation network, including the nucleus accumbens and hippocampus, and the cognitive control network, comprising the precuneus, middle cingulate cortex, and temporo-parietal junction. In contrast to their low math anxiety counterparts, HMA individuals exhibit distinct brain activation within these networks. Furthermore, the functional connectivities among these regions effectively differentiate between high and low math anxiety statuses. The altered brain activation and functional connectivities in HMA among both brain networks indicated their deficits in both value processing and cognitive effort allocation. Additionally, activations in the hippocampus, middle cingulate cortex, and posterior insula mediate the relationship between math anxiety scores and the level of math avoidance, further underlining the intricate relationship between neural activity and behavior. Our study illuminates potential cognitive and neural mechanisms，which pave the way for a deeper understanding of the challenges faced by individuals with high math anxiety and may inform targeted interventions to mitigate math avoidance behaviors.
GBS-MeDIP: A combination of methods for multi-omic identification of genetic and epigenetic variants in tumors
Authors: Pertille Fábio , Rezaei Shiva , Uffenorde Julia , Gimm Oliver , feizi Mohammad Hosseinpour , Coutinho Luiz , Guerrero-Bosagna Carlos
Published: July 2024

Tumor development, both malignant and benign, is multifactorial and linked both to genetic and epigenetic alterations. DNA methylation, an essential mechanism of epigenetic modification, plays a pivotal role in the development of various diseases, including cancer. Therefore, the development of multi-omic high throughput sequencing methods with the ability of parallel genetic and epigenetic profiling can leverage discoveries in biomedical studies. We recently introduced a novel combination of methodologies, called GBS-MeDIP (Genotype by sequencing integrated with Methylated DNA ImmunoPrecipitation), for the parallel identification of genetic and epigenetic markers in the same reduced fraction of the genome across individuals. In the present paper we show its application in two case studies to investigate methylomic and genetic variations (single nucleotide polymorphisms and copy number variations) in two types of human tumors, gastric and parathyroid. Our method identified epi/genetic markers covering the whole human genome. Our method is a simple, cost-effective approach, which uses small starting amounts of DNA, and enables the interrogation and integration of different levels of omic data in tumor research.
Aerobic exercise improves ventricular remodeling by promoting macrophages to phagocytose dying cardiomyocytes in heart failure model
Authors: Shen Yuqin , Liu Xiaoling , Li Chun , Fan Yuxuan , Zhou Zhongyan , Xiu Wenjuan , Tang Baopeng , Wang Lemin , Song Haoming , Tang Jingyi , Li Siguang , Lu Lixia
Published: July 2024

Heart failure (HF), the terminal stage of various forms of cardiovascular disease, is a severe disorder characterized by pathological cardiac fibrosis, ventricular remodeling, and reduced heart function. Chamber remodeling is the basic pathological mechanisms of HF. Aerobic exercise training (AET) as one of the non-pharmacological treatments of cardiac rehabilitation, has become one of the important therapeutic means for the long-term management of chronic HF, but how AET can improve the process in HF has not been well clarified. This study aims to determine the role of AET in pathological cardiac remodeling in HF and its potential mechanisms. We identified AET promoting the clearance of apoptosis cardiomyocytes by boosting interactions of cardiomyocytes-macrophages in HF. Lgmn was associated with the efferocytosis elevation of macrophages by AET. In addition, AET, improving the ventricular remodeling and strengthening heart function ultimately, upregulation of the anti-inflammatory mediators and downregulationof the proinflammatory mediators by boosting the expression of Lgmn in chronic repair stage of HF.Our results link AET to efferocytosis elevation of macrophages in the chronic repair stage of heart injury and identify AET as a significant prevention and therapeutic of ventricular remodeling in HF to mediate proper inflammation resolution and cardic function increase.
Interactions between Helcococcus kunzii and Staphylococcus aureus: How a commensal bacterium modulates the virulence and metabolism of a pathogen in a chronic wound in vitro model
Authors: Durand Benjamin A.R.N , Grenga Lucia , Morsli Madjid , Armengaud Jean , Lavigne Jean-Philippe , Dunyach-Remy Catherine
Published: July 2024

Background
Staphylococcus aureus is the predominant pathogen isolated in diabetic foot infections. Recently, the skin commensal bacterium Helcococcus kunzii was found to modulate the virulence of this pathogen in an in vivo model. This study aims to elucidate the molecular mechanisms underlying the interaction between these two bacterial species using a proteomic approach.
Results
Our results demonstrate that H. kunzii can coexist and grow with S. aureus in a Chronic Wound Media (CWM), mimicking an in vitro chronic wound environment. We observed that the secreted proteome of H. kunzii induced a transcriptional effect on S. aureus virulence, leading to a decrease in the expression level of agrA, a gene involved in quorum sensing. The observed effect may be attributed to specific proteins secreted by H. kunzii including polysaccharide deacetylase, peptidoglycan DD-metalloendopeptidase, glyceraldehyde-3-phosphate dehydrogenase, trypsin-like peptidase and an extracellular solute-binding protein. These proteins potentially interact with the Agr system, affecting S. aureus virulence. Additionally, the virulence of S. aureus was notably impacted by alterations in iron-related pathways and components of cell wall architecture in the presence of H. kunzii. Furthermore, the overall metabolism of S. aureus was reduced when cocultured with H. kunzii.
Conclusion
Future investigations will focus on elucidating the role of these excreted factors in modulating virulence.
Modeling and simulation on the spreading dynamics of public opinion information in temporal group networks
Authors: Wang Jiakun , Mu Linru , Chun Liu , Guo Xiaotong
Published: July 2024

Under the new media environment, the constantly emerging social platforms further expand the channels for the propagation of public opinion. In view of this, modeling the spreading dynamics of public opinion in group networks is of great significance for understanding its spreading law and improving the governance system of cyberspace. Through analyzing the changes of group networks topology and the spreading rules of public opinion, the spreading model of public opinion in temporal group networks was proposed by coupling the two dynamic processes, and the spreading thresholds of public opinion in static and temporal group networks were derived respectively. Then, the spreading characteristics of public opinion under different network topology, as well as the influence of important parameters on public opinion spreading process were discussed with the help of simulation experiments. The research results indicated that the propagation of public opinion in static and temporal group networks exhibits both similar trends and differentiated characteristics: compared with Spreader, the propagation of public opinion in temporal group networks is more sensitive to Ignorant’s behavior; the active probability of both groups and netizens affect the spreading process of public opinion, but netizens’ active probability affect more. Based on the relevant results, this paper proposed a series of countermeasures such as, grading social platforms, strengthening relationship management between them and introducing time management systems, so as to promote the formation of a good network ecosystem and the modernization of the national governance system.
The challenging management of a Cotard´s Syndrome: a case report
Authors: Sousa Bárbara Castro , de Sá Zoé Correia , Ramos Joana
Published: July 2024

Psychiatric disorders exhibit diverse presentations, giving rise to a plethora of therapeutic approaches, wherein the trajectory and treatment response can serve as predictive indicators of recuperation. Catatonia, an autonomous syndrome, can manifest across various mental and organic contexts, boasting a worldwide prevalence impact of 9.2%. Even rarer is the convergence of catatonia with nihilistic delusions – a fusion exemplified by Cotard's Syndrome – a rarity observed among patients. Thus, drawing from the portrayal of a unique case involving an inaugural psychotic episode characterized by treatment resistance, the author emphasizes the importance of successive adjustments in antipsychotic therapy, fostering a more efficient approach to treating patients grappling with refractory psychotic conditions.
Patient with advanced aggressive B2 thymoma achieved positive outcomes post CAP-Endostar combination therapy
Authors: Zhang Min , Zhang Jingjing , Zhao Kelei , Yuan Xiaohan , Zhang Jinghang , Liu Yanting , Lu Ping
Published: July 2024

This case report features a patient with an invasive thymoma. The patient presented with an anterior mediastinal mass that invaded the left brachiocephalic trunk vein, resulting in the formation of a carcinoma thrombus in the right atrium-superior vena cava-left brachiocephalic trunk vein and left internal jugular vein (Masaoka stage IV). No indication for surgery was assessed by surgical consultation. Following 6 cycles of chemotherapy and chest radiotherapy, the patient achieved a significant improvement in efficacy. After a follow-up of 40 months, the patient remained well, without local recurrence or distal metastasis, and maintained a partial response (PR) .
Learning Superior Energy Management from Electric Vehicle Data
Authors: He Hongwen , Wang Yong , Wu Jingda , Wei Zhongbao , Sun Fengchun
Published: July 2024

Despite the promising potential of energy management technologies in optimizing electric vehicle (EV) performance and fostering global energy sustainability, the extensive research conducted over the past decade has yet to translate into practical applications. This discrepancy arises primarily from the reliance of existing methodologies on simulation-based development paradigms, leading to a significant disparity between simulated results and real-world efficacy. Herein, we present a pioneering real-world data-driven energy management strategies (EMS) approach that utilizes an innovative offline reinforcement learning (ORL) framework. This paradigm enables EMS to learn from diverse real-world data, obviating the need for explicit rule design or high-fidelity simulators, and allowing for seamless application of the proposed method to any existing EMS. Moreover, it continuously enhances performance even after deployment in actual energy management systems. We evaluate the proposed ORL method on fuel cell EVs, training the ORL agent to optimize energy consumption and system degradation. The EV monitoring and management platform in China provides real-world data for validating our methodology. The results demonstrate that ORL consistently learns superior EMS in various conditions. With increasing data availability, its performance improves significantly, from 88\% to 98.6\% relative to theoretical optimality after two data updates. After training with more than 60 million kilometers of data, the ORL agent can learn a general EMS that adapts to unseen and corner-case conditions. These results highlight the effectiveness of integrating the data-driven method with established EMS techniques to enhance performance and underline its potential to utilize large-scale data to improve vehicle energy efficiency and longevity.
Outputs from a model of co-research with older care-experienced people in Sweden to advance eldercare services
Authors: Wallcook Sarah , Dohrn Ing-Mari , Dahlkvist Ulla , Domeij Yvonne , Green Kerstin , Isaksson Gigi , Goliath Ida
Published: July 2024

Background: Within the contemporary policy turn towards co-production and co-research in Sweden, older people, practitioners and researchers alike have expressed uncertainty about how to undertake co-research. Moreover, scepticism persists about the merits and contributions of co-research and co-production to research and service development. In this paper, we aim to describe a co-research model developed with older care-experienced lay co-researchers and explore the utility of our model’s outcomes to social care research and practice.
Method: In a Participatory Action Research project we established a team of three co-researchers by professional experience and eight lay co-researchers by lived experience who were over age 75. Our team undertook a complete study cycle from inception and funding through to knowledge exchange and dissemination. Our process lasted one year and comprised three phases: the group alone establishing collective knowledge, testing knowledge in peer interviews with acquaintances, exchanging knowledge in events with multi-sector actors. We generated and analysed data concurrently in fortnightly workshops and round-table meetings using procedures inspired by framework analysis to produce themes illustrated by vignettes.
Findings: We highlight our co-research model’s utility to social research, policy and practice under three themes. Expressly, how our approach 1) reaches and engages older people who are isolated at home, 2) generates out-of-the box thinking and innovative solutions for service development and research, 3) recognizes and benefits from older people’s authentic experience and knowledge. We critically reflect upon these three themes and the conditions that lead towards or away from the adoption of key co-creation principles.
Conclusions: Public services and research and development units working in the interests of older people can take inspiration from our co-research model when seeking to meet the challenges brought by new reforms towards closer community involvement. Despite messiness in the process, integrating and embedding principled co-research and co-production can bring clarity and structure to the issues that matter most to older people, and draw organisations closer to the communities they serve.
Efficacy of Lumbar Support on Pain, Disability, and Motor Control in Women with Postpartum Pelvic Girdle Pain: a Three-armed Randomized Controlled Trial
Authors: Jafarian Fahimeh-Sadat , Jafari-Harandi Mahmonir , Yeowell Gillian , Sadeghi-Demneh Ebrahim
Published: July 2024

Background
Pregnancy-related posterior pelvic girdle pain (PPGP) is a common cause of back pain and disability in the postpartum period. The objective of this study was to investigate the efficacy of orthotic support on pain, disability, and motor control in women with pregnancy-related PPGP.
Methods
Eighty-four women with a clinical diagnosis of pregnancy-related PPGP participated in this randomized controlled trial (RCT). Participants were randomly allocated into three groups (with a ratio of 1:1:1): the pelvic support group, the lumbar support group, and the control group (patient-education leaflet). Pain severity, disability, effort during the active straight leg raising test (ASLR), maximum isometric muscle force (hip flexion and trunk rotation), and joint position reproduction (JPR) of hip abduction were assessed as study outcomes. These variables were measured at four time points—before the intervention, immediately after the intervention, at the 4-week follow-up (at this time, the intervention period was terminated), and at the 5-week follow-up (one week after discontinuing the interventions)—to evaluate the possible effects of wearing support. Repeated-measures multivariate analysis of variance (MANOVA) was applied to determine the statistical significance between groups. Bonferroni post-hoc correction was used to identify significant differences between groups at different study time points.
Results
There was a significant interaction effect for group×time for the study outcomes, including pain severity, disability, effort during the ASLR, and maximum isometric muscle force between groups (p < 0.001), except JPR of hip abduction (p = 0.13). There were statistically significant differences in post hoc comparisons for pain intensity and effort during the ASLR in lumbar support versus control condition and for maximum isometric muscle force in orthotic interventions versus control conditions immediately after the intervention (P < 0.008). Post hoc tests demonstrated statistically significant differences in orthotic interventions versus control conditions after 4-week and 5-week follow-ups (P < 0.008). None of the interventions significantly changed the JPR of hip abduction compared to the control group (p > 0.008).
Conclusions
For women with pregnancy-related PPGP, both lumbar and pelvic supports were beneficial for decreasing pain and disability symptoms. Lumbar support showed better results for managing PPGP than pelvic support.
Clinical Trial registration: Iranian Registry of Clinical Trials IRCT20150210021034N11. Date of registration: April 31, 2021. Available at: https://irct.behdasht.gov.ir/trial/70670
Spatial Overlap Between Latent Mycobacterium Tuberculosis Infection and Venezuelan Migrants
Authors: Zambonin Fernanda , Júnior Nilson Cavalcante de Souza , Maciel Elvira Maria Godinho de Seixas , Braga Jose Ueleres
Published: July 2024

Background
Migrants are a high-risk group for TB and LTBI due to social determinants of health, such as poor living conditions and limited healthcare access. Since 2015, Roraima has faced significant Venezuelan migration, necessitating enhanced health surveillance efforts. Understanding the geographical conditions and their impact on migrants' health is crucial. This study aimed to evaluate the spatial overlap of TB and LTBI incidence in Boa Vista, Roraima, and its correlation with the Venezuelan migrant population from 2018 to 2022.
Methods
An ecological study was carried out, using data from the Tuberculosis Notifiable Diseases Information System and the Information System for LTBI. The study population consisted of TB-notified cases and LTBI living in Boa Vista during the study period. Spatial distribution patterns were assessed with thematic maps and local Getis-Ord statistics to identify hotspots, Kendall's W statistics to assess the TB and LTBI incidence overlap, and the Pearson correlation coefficient to evaluate the relationship between LTBI incidences and the proportion of Venezuelan migrants.
Results
Typical heterogeneous distributions of both LTBI and TB were observed; TB hotspots were present in the western and southern zones, and LTBI in the central and southern zones. The overlapping of the incidence of LTBI and TB pointed to significant agreement between the average annual incidence rates of LTBI and TB. There was a significant correlation between the LTBI incidence rate and the proportion of Venezuelan migrants.
Conclusion
The identification of LTBI risk areas could support health surveillance actions and targeted control and prevention and measures, especially for vulnerable populations.
HA: An influential node identification method based on hub-triggered neighborhood decomposition and asymmetric order-by-order recurrence model
Authors: Zhao Min , Ye JunHan , li JiaYun
Published: July 2024

In recent years, the proliferation of major power network security incidents triggered by malicious attacks has drawn widespread attention to influential nodes in power networks. Among the existing influential node identification algorithms, the global algorithms are too complex and not suitable for large-scale networks. The local algorithms are too simply to ignore the differentiated features of the same node in different information dissemination processes. To overcome these shortcomings, this paper proposes a novel influential node identification method based on hub-triggered neighborhood decomposition and asymmetric order-by-order recurrence model. The concepts of network directionalization strategy and hub-triggered neighborhood decomposition are introduced to distinguish the functional differences between nodes in the virus-spreading process. Moreover, this paper proposes the concepts of infected potential and infecting potential, and constructs a calculation model with asymmetric characteristics based on the order-by-order recurrence method to make full use of the information in the connection structure of the adjacent neighborhood. Finally, the influence of the hub node is evaluated by integrating the infected potential and infecting potential of neighbors of multiple orders. Experimental results show that the algorithm proposed in this paper outperforms the other six algorithms in terms of SIR correlation coefficient, imprecision function and algorithm resolution.
Clinical Perinatal Management of High-Risk Fetal Congenital Pulmonary Airway Malformation
Authors: Cai Chun , Tian Miao , Liu Cuifen , Zhang Gang , Li Xiao , Zhou Bin , Sun Yuling , Yu Gang
Published: July 2024

Objectives: To summarize the clinical experience in managing high-risk fetuses with congenital pulmonary airway malformation (CPAM).
Design: A retrospective analysis of integrated management clinical data was conducted for high-risk fetuses with CPAM treated at the Third Affiliated Hospital of Guangzhou Medical University and Guangdong Women and Children Health Hospital from 1st July 2015 to 30th June 2021. Data were collected before, during, and after birth.
Setting: Third Affiliated Hospital of Guangzhou Medical University and Guangdong Women and Children Health Hospital. Patients: A total of 51 patients were included in the study.
Intervention: Prenatal maternal glucocorticoid (GC) treatment was administered in 27 cases.
Measurements and Main Results: Prenatal data showed the first diagnosis at 22.90±2.34 weeks' gestation with a prenatal ultrasound congenital pulmonary airway malformation volume ratio (CVR) value of 3.08±0.91. Lesions were diagnosed in the left lung in 27 cases (52.9%), with microcystic changes present in 12 cases (23.5%). Mediastinal shift was observed in 23 cases (45.1%), with 20 cases (39.2%) exhibiting fetal hydrops. Prenatal maternal glucocorticoid (GC) treatment was administered in 27 cases, with a survival rate of 81.4% in the GC group and 95.8% in the non-GC group, showing no statistical difference (P=0.116). Postnatal data indicated an average gestational age of 37.98±2.63 weeks, with 13.7% of patients having a 5-minute Apgar score of less than 8. Neonatal surgery was performed in 17.6% of patients, all of which were lobectomies. The survival rate for high-risk CPAM infants was 88.2%, with 70.6% showing no respiratory symptoms after birth. The presence of fetal hydrops, microcystic type, and mediastinal shift did not significantly increase the risk of death. Over the 6-year follow-up period, 12 cases (26.7%) developed pectus excavatum.
Conclusions: Managing high-risk congenital cystic adenomatoid malformation (CCAM) fetuses during the perinatal period remains challenging, but the overall prognosis is generally reasonable. Glucocorticoids may have a role in improving the outcome of high-risk CPAM fetuses, although the statistical significance is still uncertain.
An integrated strategy for pathogen surveillance unveiled Xylella fastidiosa ST1 outbreak in hidden agricultural compartments in the Apulia region (Southern Italy)
Authors: Cornara Daniele , Boscia Donato , D’Attoma Giusy , Digiaro Michele , Ligorio Angela , Loconsole Giuliana , Minutillo Serena Anna , Montilon Vito , Palmisano Francesco , Ragone Gianvito , Silletti Maria Rosaria , Verrastro Vincenzo , Zaza Claudio , Saponari Maria
Published: July 2024

Annual surveillance programs for the plant pathogenic bacterium Xylella fastidiosa are implemented in Europe as part of the preventive phytosanitary strategies enforced to face the emergence of the detrimental infections reported in olives in southern Italy. The program includes inspections and sampling of host plants by prioritizing those showing suspicious symptoms or those known to be highly susceptible to different strains and subspecies of the bacterium. In the framework of these programs numerous outbreaks have been unraveled, with several strains and subspecies found to infect a relatively large host range in France, Spain, Portugal and Italy. Here we report the results of an integrated surveillance approach implemented in the Apulia Region (southern Italy), where a conventional survey program on host plants is complemented by monitoring and testing for X. fastidiosa the insect vectors. In the framework of this program, infective spittlebugs were first intercepted in the Xylella-free area of the region, close to one of the most relevant Italian table grape production district. Such findings prompted further investigation to identify the bacterial reservoir in the host plants. Almond and grapevine were found to be the most frequently infected hosts, with infections caused by isolates of X. fastidiosa subspecies fastidiosa ST1. Investigations are ongoing to assess the extent and history of the outbreak, to assess and estimate the potential impacts, and define the best options for its containment.
Mutations of methionine 444 interacting with T1Cu-coordinating amino acids affect the structure and function of multicopper oxidase CopA
Authors: Tang Wenwei , Jin Xiaoyu , Zhang Peiqi , Li Xiaorong , Chen Shichao , Zeng Xinping
Published: July 2024

Manganese is an essential trace element for humans, animals, and plants, but excessive amounts of manganese can cause serious harm to organisms. The biological manganese oxidation process mainly oxidizes Mn(II) through the secretion of unique manganese oxidase by manganese-oxidizing bacteria. The T1 Cu site of multicopper oxidase is the main site for substrate oxidation, and its role is to transfer electrons to TNC, where dioxygen reduction occurs. In this study, methionine (Met) No. 444 interacting with the T1Cu-coordinating amino acid in the multicopper oxidase CopA from Brevibacillus panacihumi MK-8 was mutated to phenylalanine (Phe) and leucine (Leu) by the enzyme. Based on the analysis of enzymatic properties and the structural model, the mutant protein M444F with 4.58 times the catalytic efficiency of the original protein CopA and the mutant protein M444L with 1.67 times the catalytic efficiency of the original protein CopA were obtained. The study showed that the manganese removal rate of the manganese-oxidizing engineered bacterium Rosetta-pET-copAM444L cultured for 7 days was 88.87%, which was 10.77% higher than that of the original engineered bacterium. Overall, this study provides a possibility for the application of genetic engineering in the field of biological manganese removal.