bluuebunny/crossref_metadata_2025 huggingface dataset:
Uso de terapias mente-cuerpo y transtornos mentales en estudiantes de Medicina Humana durante la pandemia por COVID-19
Authors:   , Vizquerra Sifuentes Tania Desiree , Ojeda Chavez Maria Estela
Published: June 2022

Introducción: El uso de las terapias mente-cuerpo es una buena alternativa no farmacológica para abordar la presencia de trastornos mentales en estudiantes de medicina, considerando el contexto de la pandemia por COVID-19. El objetivo del estudio es determinar la asociación entre los trastornos mentales y el uso de terapias mente cuerpo en estudiantes de Medicina Humana (MH) de la Universidad Científica del Sur. Metodología: Se realizó un estudio transversal analítico observacional, en 384 estudiantes de la carrera de Medicina Humana de la Universidad Científica del Sur. A través de un cuestionario con line se recogieron variables sociodemográficas y clínicas, donde se incluyó la versión en español de escala de Ansiedad, Depresión y estrés (DASS-21), entre marzo y abril del 2021. Resultados: El 28,6% realizó alguna terapia mente-cuerpo, de los cuales el 70% son del sexo femenino. El trastorno mental más frecuente fue depresión con 68,49%, seguido de ansiedad con 65,89% y por último estrés con 63,27%. El 26,82% de los estudiantes tuvo COVID-19 y la terapia mente-cuerpo más prevalente fue el yoga. Conclusiones: Los trastornos mentales están asociados con haber usado alguna terapia mente-cuerpo junto con la edad, sexo, haber tenido COVID-19 y llevado el curso de medicina tradicional, alternativa y complementaria. Esto las convierte en una buena alternativa no farmacológica para lidiar con los diversos desafíos que nos presenta la carrera.
Factores asociados al Síndrome de Burnout en estudiante de Medicina en una Universidad Privada del Perú durante la pandemia COVID-19
Authors:   , Oliva Soel Nayélih Berna , Pariona Pipa Laidy Arely
Published: June 2022

Objetivo: Determinar los factores asociados al síndrome de burnout (SB) en estudiantes de medicina en una universidad privada del Perú durante la pandemia COVID-19. Materiales y métodos: Se realizó un estudio observacional, analítico, transversal y correlacional entre los meses de junio a agosto del 2021. El muestreo se realizó en bola de nieve, obteniéndose 353 participantes, estudiantes de medicina de 3° a 11° ciclo académico, aplicándose la Escala Unidimensional de Burnout Estudiantil. Además, una ficha de datos personales (sociodemográficos, datos relacionados al COVID-19 y a la enseñanza universitaria). El análisis estadístico se realizó mediante las pruebas Kruskal-Wallis, Chi-cuadrado de Pearson y test exacto de Fisher, según el tipo de variable. Así también, se realizó el cálculo de OR mediante regresión logística. Con un nivel de confianza del 95%, y una potencia del 80% y consideramos significancia estadística cuando p<0.05. Resultados: Todos los alumnos encuestados presentaron algún grado del SB (SB leve n=26, SB moderado n=96, SB profundo n=231). Las variables que se asociaron al SB estudiantil fueron: diagnóstico de COVID-19 en los estudiantes (p<0.000), el convivir con algún familiar con diagnóstico de COVID-19 (p=0.011), el número de personas con las que convive el estudiante (p=0.001), la situación laboral del apoderado (p=0.005), el ciclo académico (p=0.002); la conectividad durante las clases universitarias (p<0.000) y percepción de la calidad de la enseñanza durante la pandemia (p<0.000). Conclusiones: Los factores que aumentaron la razón entre estudiantes de medicina con SB profundo versus SB leve o moderado fueron: diagnóstico de COVID-19 en los estudiantes, convivir con algún familiar con diagnóstico de COVID-19 y el número de personas con las que convive; y aquellos factores que disminuyeron esta razón fueron: apoderado con condición de empleado durante la pandemia, conectividad a internet y percepción de la calidad de enseñanza.
Comparación entre peso fetal y peso real al nacer en gestantes con pelvis estrecha programadas para cesárea en el Hospital Maria Auxiliadora, DISA Lima Sur, en el periodo de octubre a diciembre 2019
Authors:   , Castillo Caciano Lorena Isabel , Reiter Limas Jackeline Nicole
Published: June 2022

Objetivo: Determinar la correlación entre el peso fetal ecográfico y el peso real al nacer en una muestra de mujeres cesareadas con pelvis estrecha durante el periodo octubre a diciembre del 2019. Materiales y métodos: Se realizo un estudio de tipo observacional, cuantitativo, analítico, correlacional, de corte transversal. Nuestra variable principal fue el peso real al nacer. La variable respuesta fue el peso fetal ecográfico calculado mediante la fórmula de Hadlock 4. Resultados: Se trabajo un total de 62 historias clínicas. La correlación fue estadísticamente significativa entre el peso ecográfico y el peso real al nacer, en la población existe correlación montómica positiva muy fuerte con un 0.91 (p=<0.001). El análisis de regresión, el peso fetal ecográfico disminuye en 0.88 gramos por cada gramo que incrementa el peso real al nacer; ajustado por la edad gestacional. Conclusiones: El estudio mostró que el peso fetal mediante ecografía es confiable para tomar decisiones obstétricas, como en el caso de indicación de cesárea.
Experimental evidence of non-classical brain functions
Authors: Kerskens Christian Matthias , Perez David Lopez
Published: June 2022

Recent proposals in quantum gravity have suggested that unknown systems can mediate entanglement between two known quantum systems, if and only if the mediator itself is non-classical. This approach may be applicable to the brain, where speculations about quantum operations in consciousness and cognition have a long history. Proton spins of bulk water, which most likely interfere with any brain function, can act as the known quantum systems. If an unknown mediator exists, then NMR methods based on multiple quantum coherence (MQC) can act as entanglement witness. However, there are doubts that today’s NMR signals can contain quantum correlations in general, and specifically in the brain environment. Here, we used a witness protocol based on zero quantum coherence (ZQC) whereby we minimised the classical signals to circumvent the NMR detection limits for quantum correlation. For short repetitive periods, we found evoked signals in most parts of the brain, whereby the temporal appearance resembled heartbeatevoked potentials (HEPs). We found that those signals had no correlates with any classical NMR contrast. Similar to HEPs, the evoked signal depended on conscious awareness. Consciousness-related or electrophysiological signals are unknown in NMR. Remarkably, these signals only appeared if the local properties of the magnetisation were reduced. Our findings suggest that we may have witnessed entanglement mediated by consciousness-related brain functions. Those brain functions must then operate non-classically, which would mean that consciousness is non-classical.
Bacillus strains with potential for growth promotion and control of white mold in soybean
Authors: Duré Laís Mayara Melo , Galeano Rodrigo Mattos Silva , Viana Thianny Fernanda Carrelo , Roque Cassiano Garcia , Matias Rosemary , Paggi Gecele Matos , Corrêa Bianca Obes , Brasil Marivaine Silva
Published: June 2022

Plant growth-promoting rhizobacteria (PGPR) are known to stimulate the biocontrol of phytopathogenic bacteria and fungi, induce plant growth, and increase the yield of important economic crops. In this study, we evaluated in vivo, the ability of Bacillus strains to control soybean white mold disease and promote the growth of soybean plants under greenhouse conditions. Initially, 27 Bacillus strains were analyzed by PCR for the presence of genes encoding antimicrobial molecules, followed by in vitro tests of the positive strains against four phytopathogenic fungi, Sclerotinia sclerotiorum, Macrophomina phaseolina, Rhizoctonia solani, and Colletotrichum truncatum. The bacterial strains that returned positive results for antimicrobial genes were evaluated in vivo for their growth promoting capacity in soybean cultivars Potencia RR and M6210 IPRO, and white mold control in soybean plants. The results showed that eight strains presented the genes bamD, ituD, and fenF, while the bacAB gene was observed in 16 of all tested Bacillus strains. Briefly, the inoculation of the strain VBN02 in increased the fresh biomass of shoots and roots by 111.9% and 79.39% compared with the control. The greenhouse experiment showed that the inoculation of the strain VBN02 was the best treatment for increasing fresh shoot biomass of the soybean M6210 IPRO and Potencia RR cultivar in the single inoculation in relation to the control (111.9% and 103.57%, respectively). Co-inoculation of soybean inoculant and VBE01 was the superior treatment for increasing fresh shoot and root mass in both the cultivars. Two other strains, VBE05 and VBE01, reduced the disease progression of white mold by 39.1% and 37.5%, respectively. In conclusion, our results showed that the Bacillus strains have potential for biocontrol of white mold and for promoting the growth of soybean plants.
Food aversion, Pica and Cravings Practices and Its Associated Factors among Pregnant Women Attending Antenatal Care in Nifas silk sub-city Health Facilities, Addis Ababa, Ethiopia, 2021
Authors: Sale Getachew , Fikadu Mekdelawit , Gizaw Getu , Tamiru Dessalegn
Published: June 2022

Background
Although food cravings, aversions, and pica behaviors are practiced globally, they are more common in African countries. No clear evidence indicated on malpractices during pregnancy. Therefore, this study aims to investigate pica, food aversion, and craving practices and their associated factors in the study area.
Objectives
To assess the prevalence of pica practice, food aversion, craving and its associated factors among pregnant women attending antenatal care in Nifas Silk sub-city health facilities, Addis Ababa Ethiopia, 2021
Methods
An institution-based cross-sectional study was conducted among 502 pregnant mothers from July 15 to August 15, 2021. Data were enterd to EpiData version 3.1 and analyzed by SPSS version 21.The binary logistic regression model was fitted to identify factors associated with pica, food aversion and craving.
Results
The prevalence of pica practices,food aversion and craving were 22%,40.8% and 85% respectively. Maternal education level status [AOR, 2.95(1.14,7.62)], using family planning[AOR, 2.35 (1.34, 4.12)], Iron/folate supplementation [AOR, 2.45 (1.47,4.05)] and having pregnancy related complication[AOR, 2.45 (1.47, 4.05)] were significantly associated with pica practice. Maternal age 19–24 and 25–29 years[AOR, 0.17 (0.06,0.44)] and [AOR, 0.56 (0.34,0.89] respectively, ANC visit [AOR, 0.14(0.08, 0.34], Nutritional status[AOR, 2.25 (1.06, 4.78)], IFA supplementation [AOR, 0.20 (0.10, 0.38)], Pregnancy related complication were factors associated with food craving. Additionally, maternal income[AOR,0.44(0.24,0.81)],family planning user[AOR,3.45(2.21,5.40)], IFA supplementation[AOR, 2.47(1.59, 3.85)] were factors associated with food aversion.
Conclusion
Pica, food aversion and food craving during were prevalent. Maternal educational level, family planning users, iron folate supplementation and pregnancy complications were significantly influenced pica practice. Maternal age, ANC and IFA supplementation were decreases the food craving practices while maternal undernutrition increases food craving. Additionally, family planning users, IFA supplementation and income were factors associated with food aversion. Therefore, those malpractices should be decreased by working on identified factors. Increases the maternal health services during pregnancy should strengthen to alleviate these malpractices.
Machine learning for morbid glomerular hypertrophy
Authors: Kataoka Hiroshi , Ushio Yusuke , Iwadoh Kazuhiro , Ohara Mamiko , Suzuki Tomo , Hirata Maiko , Manabe Shun , Kawachi Keiko , Akihisa Taro , Makabe Shiho , Sato Masayo , Iwasa Naomi , Yoshida Rie , Hoshino Junichi , Mochizuki Toshio , Tsuchiya Ken , Nitta Kosaku
Published: June 2022

Background:A practical research method integrating machine learning with conventional statistics has been sought in medicine. Although glomerular hypertrophy (or a large renal corpuscle) on renal biopsy has pathophysiological implications, it is often misdiagnosed as adaptive/compensatory hypertrophy. We explored the factors associated with a maximal glomerular diameter of ≥242.3 μm using machine learning. Methods:Using the frequency-of-usage feature ranking in predictive models, we defined the machine learning scores calculated from symbolic regression models. We compared features selected by genetic programming with those selected by a point-biserial correlation coefficient using multivariable logistic and linear regression to validate discriminatory ability, goodness-of-fit, and collinearity. Results:Body mass index, complement component C3, serum total protein, arteriolosclerosis, C-reactive protein, and the Oxford E1 score were ranked among the top 10 features with high machine learning scores using genetic programming. The estimated glomerular filtration rate was ranked 46th among the 60 features. In multivariable analyses, the R2 value was higher (0.61 vs. 0.45), and the corrected Akaike Information Criterion value was lower (402.7 vs. 417.2) in the model with features generated by genetic programming than in the model generated with features using point-biserial r. There were two features with variance inflation factors higher than 5 in the model using point-biserial r and none in the machine learning model. Conclusions:Machine learning may be useful in identifying significant and insignificant correlated factors. Our method may be generalized to other medical research due to the procedural simplicity of using top-ranked features selected by machine learning.
Temozolomide Increases Heat Shock Proteins in Extracellular Vesicles Released from Glioblastoma Cells
Authors: KIYGA Ezgi , Adıgüzel Zelal , Uçar Evren Önay
Published: June 2022

ABSTRACT
Background: Glioblastoma (GBM) is the most malignant and the fastest-progressing type of primary brain tumours. Temozolomide (TMZ) is a chemotherapeutic drug for the treatment of GBM. Extracellular vesicles (EVs) have been recently confirmed to have a substantial role in the GBM, and their contents released from GBM cells have been considered a target for treatment. The purpose of this study is to evaluate the impact of TMZ on heat shock proteins (HSPs) derived from EVs originated from GBM cell lines (U87-MG and LN229) and the significance of EVs in response to chemotherapy in GBM.
Methods and Results: NTA, ELISA, and immunoblotting were used to characterization studies of EVs and results showed that U87-MG cells released many EVs compared to LN229 cells. The effect of TMZ treatments on HSPs expression levels were assessed with immunoblotting and was found to be led to increases in HSF-1, Hsp90, Hsp70, Hsp60 and Hsp27 expression in GBM cells and their EV contents, which these increases are related to therapeutic resistance. What is more, in Real-time PCR studies showing which signalling pathways might be associated with these increases, it was observed that TMZ triggered the expression of RAD51 and MDM2 genes in cells and EV contents. More strikingly, we discover a correlation between EV and parental cells in regard of mRNA and protein level in both cell lines as a result of TMZ treatment.
Conclusions: Our data suggest of EVs in the treatment of GBM may have potential biomarkers that can be used to investigate the treatment response.
The Impact of Clinical Pharmacist-physician Communication on Reducing Drug-related Problems: a RCT in a Tertiary Teaching Hospital in Xinjiang, China
Authors: Zheng Feiyang , Wang Dan , Zhang Xinping
Published: June 2022

BackgroundThe incidence of drug-related problems (DRP) has caused serious health hazards and economic burdens among poly-medicine patients. Effective communication between clinical pharmacists and physicians (CPP) has a significant impact on reducing DRPs, but evidence is poor.MethodsA semi-structured interview was conducted to explore the communication mode between CPPs based on the interprofessional approach of the shared decision making model and Relational Coordination theory. A randomized controlled trial (RCT) was used to explore the effects of communication intervention on reducing DRPs. Logistic regression analysis was used to identify the influencing factors of communication.ResultsThe mode of communication is driven by clinical pharmacists between CPPs and selectively based on different DRP types. Normally, the communication contents only cover two (33.8%) types of DRP contents or fewer (35.1%). The communication time averaged 5.8 minutes. The communication way is predominantly face-to-face (91.3%), but telephone or other online means (such as WeChat) may be preferred for urgent task or long physical distance. Among the 367 participants, 44 patients had DRPs. RCT results indicated a significant difference in DRP incidence between the control group and the intervention group after the communication intervention (P = 0.02), and the incidence of DRP in the intervention group was significantly reduced (15.6% vs 0.07%). Regression analysis showed that communication time had negative impact on DRP incidence (OR = 13.22, p < 0.001).ConclusionFace-to face communication is mainly current practiced mode between CPPs, but they communicate few contents when dealing with DRPs. Communication mode based on the interprofessional approach of the shared decision making between CPPs in medication decision-making could significantly reduce the incidence of DRP and the length of communication time is a significant factor. The longer the communication time, the fewer DRPs occur.Trial registration:This trial was approved by the ethics committee of The First Affiliated Hospital of Medical College of Xinjiang Shihezi University Hospital (kj2020-087-03) and registered in the China clinical trial registry (https:// www.chictr.org.cn, number ChiCTR2000035321 date: 08/08/2020).
Is Globalization Driving the Use of Renewable Energy? A Global Macro Perspective
Authors: Salman Verda , Ahmad Imtiaz , Alvi Shahzad
Published: June 2022

The contemporary world has become increasingly interdependent in terms of economic, social and political development. These various forms of interdependence, usually termed globalization, help disseminate ideas, information, products, and services around the world. Increase in globalization has also increased path-dependence, affecting economic, social, and institutional development and completing some industries, products and technologies to grow in line with the global demand and changing standards. While the role of globalization in economic growth, technology transfer and institutional development is established in literature, the role of globalization in reversing environmental deterioration is not explored yet. The current study looks at how globalization has affected renewable energy use in high, upper middle and lower middle income countries. The empirical results based on a fixed effects model show that countries differ in terms of taking advantage of different types of globalization, i.e., economic, social and political, while transitioning towards renewable energy (RE) projects. Economic globalization has a positive influence on RE usage in the case of high and lower middle income countries, Social globalization in case of high and upper middle income countries. Contrary to the positive impacts of economic and social globalization, political globalization has a negative impact on RE usage in the case of high income countries. In addition to globalization, the effect of government effectiveness, GDP per capita and CO2 vary across the groups of countries.
Experience with the Tecnis Symfony Extended Range of Vision IOL in Patients with Pre- existing Retinal Pathology
Authors: Odette John , Nguyen David , Morrisette Amanda
Published: June 2022

Background: There are limited publications about multifocal IOLs and patients with pre-existing retinal pathologies. Published outcomes have been mixed, with some showing good visualization of the retina postoperatively, while others report difficulty with visualization of the retina through MIOL. This study evaluated outcomes with TECNIS Symfony® Extended Range of Vision IOL (Symfony) in patients with and without pre-existing retinal pathology.Methods: Visual acuity (VA) was retrospectively evaluated for patients who underwent cataract surgery with implantation of the Symfony IOL from 09/1/2016 to 05/31/2018 at a single, US clinical site. Month 2 postoperative outcomes were compared for eyes with (70 eyes) and without pre-existing retinal pathology (616 eyes). Outcomes included mean monocular uncorrected visual acuity (±SD) at near (UNVA) at 40 cm, far distance (UDVA) at 20 ft, and with best correction (CDVA).Results: UNVA was 0.07 ± 0.10 logMAR in the non-pathology eyes vs. 0.17 ± 0.20 logMAR in eyes with pathology (p<0.0001). Mean monocular UDVA was 0.11 ± 0.90 logMAR in the non-pathology eyes vs. 0.21± 0.19 logMAR in eyes with pathology (p<0.0001). Mean monocular CDVA was 0.02 ± 0.06 logMAR in the non-pathology eyes vs. 0.11± 0.17 logMAR in eyes with pathology (p<0.0001). Eyes with mild to moderate pathology had VA comparable with non-pathology eyes.Conclusion: In this retrospective review, the Symfony IOL provided good uncorrected and best-corrected visual acuity at near and far distances in eyes with and without retinal pathology. Trial Registration: NCT05111106 (clinicaltrials.gov)
Finding stable multi-component materials by combining cluster expansion with crystal structure predictions
Authors: Carlsson Adam , Rosen Johanna , Dahlqvist Martin
Published: June 2022

A desired prerequisite when performing a quantum mechanical calculation is to have an initial idea of the atomic positions within an approximate crystal structure. The atomic positions combined should result in a system located in, or close to, an energy minimum. However, designing low-energy structures may be challenging when prior knowledge is scarce, specifically for large multi-component systems where the degrees of freedom are close to infinite. In this paper we propose a method for identification of low-energy crystal structures in multi-component systems by combining cluster expansion and crystal structure prediction with density functional theory calculations. More importantly, we show that employing seed structures retrieved from cluster expansion models may significantly reduce the number of generations needed within the computationally demanding crystal structure prediction methodology. With this combined approach, we correctly identified the recently discovered Mo4/3Sc2/3AlB2 i-MAB phase comprised of in-plane chemical ordering of Mo and Sc and with Al in a Kagomé lattice. This result demonstrates that a combined approach provides a path for identifying low-energy crystal structures in multi-component systems by employing the strengths from both the cluster expansion method and the crystal structure prediction framework. In addition, we also address examples when cluster expansion fails to account for important structural transformations in sublattices not part of the parametrization.
Comprehensive Analysis of HNRNPR in ESCA and its High Expression Combined with 18F-FDG PET/CT Metabolic Parameters as a Novel Biomarker for ESCA Preoperative Diagnosis
Authors: Liu Xiao-Yu , Gao Yan , Kui Xue-Yan , Liu Xu-Sheng , Zhang Yao-hua , Zhang Yu , Ke Chang-Bin , Pei Zhijun
Published: June 2022

Background
The purpose of this study was to determine the expression and function of heterogeneous nuclear ribonucleoprotein R (HNRNPR) in esophageal carcinoma (ESCA), the correlation between its expression and 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computerized tomography scan (PET/CT)-related parameters, as well as whether 18F-FDG PET/CT can be used to predict the expression of HNRNPR in ESCA.
Methods
We analyzed patients with ESCA who underwent 18F-FDG PET/CT before surgery, and their tissues were stained with HNRNPR IHC. The associated parameters were derived using the 18F-FDG PET imaging data, and the correlation with the IHC score was evaluated. The Oncomine, TCGA, and GEO datasets were used to investigate HNRNPR expression in the pan- and esophageal cancers, as well as its relationship to N6-methyladenosine (m6A) modification and glycolysis. The R software, LinkedOmics, GeneMANIA, and StringOnline tools were used to perform GO/KEGG, GGI, and PPI analyses on the HNRNPR.
Results
HNRNPR is highly expressed in the majority of pan-cancers, including ESCA, and is associated with BMI, weight, and history of reflux in patients with ESCA. HNRNPR is somewhat accurate in predicting the clinical prognosis of ESCA. HNRNPR expression was positively correlated with SUVmax, SUVmean, and TLG in ESCA (p༜0.05). The combination of these three variables provides a strong predictive value for HNRNPR expression in ESCA. GO/KEGG analysis showed that HNRNPR was related to the cell cycle, DNA replication, and the Fannie anemia pathway. The analysis of the TCGA and GEO data sets revealed a significant correlation between HNRNPR expression and m6A and glycolysis-related genes. GSEA analysis revealed that HNRNPR was involved in a variety of m6A and glycolysis related-pathways.
Conclusion
HNRNPR overexpression correlates with 18F-FDG uptake in ESCA, probably by regulating cell cycle, m6A modification and cell glycolysis. 18F-FDG PET/CT-related parameters may estimate HNRNPR expression for diagnostic accuracy and biomarker of ESCA.
Survival of natural glass under hyperalkaline conditions for ~4000 years
Authors: Kikuchi Ryosuke , Sato Tsutomu , Fujii Naoki , Shimbashi Misato , Arcilla Carlo A.
Published: June 2022

Silicate glasses are durable materials in our daily life, but corrosion rate accelerates under alkaline aqueous environment. Such situation has raised concerns, for example, in nuclear waste disposal where vitrified wastes encounter to alkaline leachate from surrounding concrete materials. Here we report volcanic glass example surviving with a hyperalkaline groundwater (pH > 11) and high flow rate for about 4000 years. The tiny glass fragments were extracted from the volcanic ash layer sandwiched between ultramafic sediments using microanalytical techniques. Sharp elemental distributions at the glass surface, where amorphous-like smectite precursors and crystalline smectites coexist, suggest the corrosion by an interface-coupled dissolution-precipitation mechanism rather than inter-diffusion. The secondary minerals acted as a protective film for the glass by limiting water accessibility. The corrosion rate was maintained at, the minimum, 2.5 orders of magnitude less than the rate observed for fresh glass, even in the presence of Fe and Mg that might have consumed Si through the silicate precipitation.
TROP-2 expression in triple-negative breast cancer: correlations with tumor-infiltrating lymphocytes, histological subtypes and survival
Authors: Izci Hava , Punie Kevin , Waumans Lise , Laenen Annouschka , Wildiers Hans , Verdoodt Freija , Desmedt Christine , Ardui Jan , Smeets Ann , Han Sileny N. , Nevelsteen Ines , Neven Patrick , Floris Giuseppe
Published: June 2022

BackgroundLimited data exist regarding the associations between TROP-2 protein expression, clinicopathological characteristics, and outcome in triple-negative breast cancer (TNBC). MethodsTROP-2 expression was determined for patients diagnosed with TNBC between 2000-2017 by immunohistochemistry (IHC) (ab227689, Abcam) on whole slide tumor sections, and assessed as continuous and categorical variables (H-score high, 201-300, medium 100-200 and low <100). Associations between TROP-2 expression and age, BMI, tumor grade and size, lymphovascular invasion (LVI), ductal carcinoma in situ (DCIS) presence, nodal status, stromal tumor-infiltrating lymphocytes (sTILs), androgen receptor (AR), standardized mitotic index (SMI), and outcome were assessed. ResultsWe included 685 patients with a median age at diagnosis of 54y (range 22-90y). TROP-2 expression was high, medium and low in 97 (16.5%), 149 (25.3%) and 343 (58.2%) of patients, respectively. The presence of LVI, associated DCIS, nodal involvement, apocrine histology and AR expression were correlated with higher TROP-2 levels. TROP-2 was not associated with pathological complete response (pCR). There were no associations between TROP-2 expression and time-to-event outcomes. ConclusionsIn stage 1-3 TNBC, higher TROP-2 expression was correlated with apocrine histology, higher AR expression, presence of DCIS, LVI, and nodal involvement. There was no correlation between TROP-2 expression and sTILs or outcome.
Relationships between available-holding water capacity, N-NO3- and K in the soil with parameters of nutritional status, vigour, yield, must and wine composition in the cv. Tempranillo
Authors: Martínez-Vidaurre José María , Pérez-Álvarez Eva Pilar , García-Escudero Enrique , Peregrina Fernando
Published: June 2022

Purpose
The aim of this study was to assess the relationship between the available water-holding capacity (AWC), available N-NO3− and K extractable content in the soil and the vine nutritional status, vigour, yield and quality of the musts and wines in D.O.Ca. Rioja vineyards over a period of five years (2010–2014).
Methods
The AWC, available N-NO3− and K extractable contents in the soil were analysed in twelve cv. Tempranillo plots. Vine yield and nutritional parameters were determined, as well as the K and polyphenols compounds in the musts and wines.
Results
In general, both the AWC and the N-NO3− content correlated positively with the N and K content of the petiole, the shoot weight, and the bunch weight, but negatively with the polyphenols and anthocyanins content of the musts and wines. The K that can be extracted from the soil also correlated with the K content of the petiole, and with the K in the musts and wines.
Conclusions
The AWC, the N-NO3− and the extractable K are soil parameters which have been linked to the growth and ripening of the vine plant, as well as to the composition of the must and wine. For D.O.Ca. Rioja wine-growing sector, these soil parameters would be a suitable tool in order to select soils that allow to obtain wines of better quality.
Exploring the Contributions of Affective Constructs and Interoceptive Awareness to Feeling Fat
Authors: Morales Cate , Dolan Sarah C. , Anderson Drew A. , Anderson Lisa M. , Reilly Erin E
Published: June 2022

Purpose
Feeling fat, a subjective feeling of being overweight that does not correspond with body weight, is commonly-reported in patients with eating disorders (EDs). Research suggests that feeling fat relates to deficits in interoceptive awareness (IA), the perception and integration of signals related to body states. Relatedly, recent work has linked feeling fat to affective constructs, such as depressive symptoms and guilt. The current study explores the unique relationships between feeling fat, self-reported and objective IA, guilt, alexithymia, and depressive symptoms.
Method
Female undergraduates (N = 128) completed the 11th item of the Eating Disorder Examination Questionnaire, the Toronto Alexithymia Scale, the Guilt subscale of the Positive and Negative Affect Schedule, and the Beck Depression Inventory-II. Participants also completed two IA measures: a heartbeat perception task and the Multidimensional Assessment of Interoceptive Awareness.
Results
Results indicated that all collected measures explained 56% of the variability in feeling fat. Depressive symptoms, self-reported IA, and BMI accounted for significant variability in feeling fat. Relative weights analyses revealed that depressive symptoms accounted for the most variability in feeling fat.
Conclusions
Our results replicate previous findings that depressive symptoms relate significantly to feeling fat and extend this work by suggesting that, for ED patients with interoceptive deficits, depressed affective states contribute to feeling fat. Clarifying this relationship may provide novel targets for ED treatments. For example, endorsement of feeling fat during an intake assessment may alert clinicians to assess for depressive symptoms and focusing on these depressive symptoms in treatment may improve feeling fat.
Level of Evidence:
Level I: Evidence obtained from an experimental study
Why do knees after total knee arthroplasty fail in China: a single center's experience
Authors: Zhang Liyi , li Zhichang , Kang Wulin , Gao Xuan , Lin Jianhao
Published: June 2022

Background
The number of revision Total Knee Arthroplasty (TKA) is rising in many countries. This study aimed to assess causes for revision TKA in China and compared reasons with previously published data.
Methods
In this study patients who had revision TKA between 2007 and 2020 were retrospectively included. Revision causes were categorized using all available information from patients’ records including preoperative diagnostics, intraoperative findings as well as the periprosthetic tissue analysis’ results. Patients were divided into early (up to 2 years) and late revision (more than 2 years). The reason for revision before 2012 and after 2012 was also compared.
Results
We assessed 337 patients who underwent 373 revision TKAs. In 345 knees this was the first revision surgery after primary TKA. Among the first revisions, half of the revisions were late revisions (50.4%). Overall, the most frequent reason for the revision was infection (38.6%), followed by aseptic loosening (28.1%) and instability (10.1%). Infection (56.1%) and aseptic loosening (49.4%) were the most frequent reason for early and late revisions.
Conclusions
In our specialized arthroplasty center infection was the most common reason for revision. Infection and aseptic loosening needed to be considered for early or late-stage revision.
Degree-corrected distribution-free model for community detection in weighted networks
Authors: Qing Huan
Published: June 2022

A degree-corrected distribution-free model is proposed for weighted social networks with latent structural information. The model extends the previous distribution-free models by considering variation in node degree to fit real-world weighted networks, and it also extends the classical degree-corrected stochastic block model from un-weighted network to weighted network. We design an algorithm based on the idea of spectral clustering to fit the model. Theoretical framework on consistent estimation for the algorithm is developed under the model. Theoretical results when edge weights are generated from different distributions are analyzed. We also propose a general modularity as an extension of Newman’s modularity from un-weighted network to weighted network. Using experiments with simulated and real-world networks, we show that our method significantly outperforms the uncorrected one, and the general modularity is effective.
A comparison of MRI appearance and surgical detethering rates between intrauterine and postnatal myelomeningocele closures: a single-center pilot matched cohort study
Authors: Cools Michael J. , Tang Alan R. , Pruthi Sumit , Koh Tae Ho , Braun Stephane A. , Bennett Kelly A. , Wellons John C.
Published: June 2022

Purpose: Intrauterine myelomeningocele repair (IUMR) and postnatal myelomeningocele repair (PNMR) differ in terms of both setting and surgical technique. A simplified technique in IUMR, in which a dural onlay is used followed by skin closure, has been adopted at our institution. The goal of this study was to compare the rates of clinical tethering in IUMR and PNMR patients, as well as to evaluate the appearance on MRI. Methods: We conducted a retrospective review of 36 patients with MMC repaired at our institution, with 2:1 PNMR to IUMR matching based on lesion level. A pediatric neuroradiologist blinded to the clinical details reviewed the patients’ lumbar spine MRIs for the distance from neural tissue to skin and the presence or absence of a syrinx. An EMR review was then done to evaluate for detethering procedures and need for CSF diversion.Results: Mean age at MRI was 4.0 years and mean age at last follow-up was 6.1 years, with no significant difference between the PNMR and IUMR groups. There was no significant difference between groups in the distance from neural tissue to skin (PNMR 13.5mm vs IUMR 17.6mm; p=0.5). There was no difference in need for detethering operations between groups (PNMR 12.5% vs IUMR 16.7%; RR 0.75; CI 0.1-5.1). Conclusions: There was no significant difference between postnatal- and intrauterine-repaired myelomeningocele on MRI or in need for detethering operations. These results imply that a more straightforward and time efficient IUMR closure technique does not lead to an increased rate of tethering when compared to the multilayered PNMR.
A cold high-pressure system over North China hinders the southward migration of Mythimna separata in autumn
Authors: Zhu Jian , Chen Xiao , Liu Jie , Jiang Yu-Ying , Chen Fa-Jun , Lu Jia-Hao , Chen Hui , Zhai Bao-Ping , Hu Gao
Published: June 2022

At almost any moment, the planetary boundary layer is distributed by an unimaginably huge variety and quantity of insects, but the southward migration of insects (in the Northern Hemisphere) in autumn has still been full of mystery. We collected the daily catches of Mythimna separata, a long-distance migratory moth under a wide range of light traps in 2014–2017. The results confirmed that the migration in spring and summer under the monsoon system can bring rapid population growth. However, slow southerly wind (towards the north) was prevailing over their major summer breeding area in North China (33°-40°N) due to a cold high-pressure system occupying there, thus the autumn migration of this pest was severely disturbed. Less than 8% of moths from their summer breeding area migrated into their overwintering area successfully, resulting in a sharp decline of the population abundance in autumn. As northerly wind (toward the south) is always predominated at the eastern periphery of a high-pressure system, the cold high-pressure system going westward led to more northerly wind over North China, bringing more insects migrating southward successfully. Therefore, it was further found that an outbreak year of M. separata larval was correlated with a westward high-pressure system in the previous autumn. These results indicated that the southward migration in Autumn is crucial for the population sustaining of this pest, and the position of the cold high-pressure system in September is a key environmental driver of the population scale in the next year. This study points out that the autumn migration of insects is more complex than previously recognized, and the meteorological conditions in autumn are an important driver of migratory insects’ seasonal and interannual population dynamics.
Multi-agent Approach for Vehicle-to-Infrastructure Routing in VANETs: A Machine Learning Framework
Authors: Sataraddi Mamata J. , Kakkasageri Mahabaleshwar S. , Bandi Ajay , Pujar Rajani S.
Published: June 2022

The vehicular network plays a significant role in understanding the detailed study of vehicle communications. Multiple vehicles in the local communication range need to exchange the safety and infotainment information via common roadside infrastructure in Vehicular Ad hoc Networks (VANETs). The vehicle-to-Infrastructure (V2I) communication model helps to improve the efficiency of the intelligent transport system by providing safety warnings and reducing vehicle collisions. Machine learning is an artificial intelligence component that allows the machine to learn without being expressly trained to improve from experience automatically. Since VANET is imprecise and uncertain, Machine Learning (ML) and Software Agents (SAs) combining approaches resolve the issues of V2I communication challenges in VANETs. This paper proposes ML-based V2I Communication in VANETs using a software agent approach. The proposed agent-based model is made up of both static and mobile agents. The proposed model executes the decision tree algorithm to identify the event as non-critical or critical. The Q-Learning algorithm identifies the destination vehicle with improved bandwidth utilization, packet delivery ratio, end-to-end delay, V2I communication delay, and throughput and control overheads.
COVID-19 risk perception framework of the public: An infodemic tool for future pandemics and epidemics
Authors: Lohiniva Anna-Leena , Pensola Annika , Hyökki Suvi , Sivelä Jonas , Tammi Tuukka
Published: June 2022

Understanding risk perceptions of the public is central for risk communications and infodemic management during emergency and preparedness planning as people’s behavior depends on how they perceive the related risks. This qualitative study aimed to identify and describe factors related to COVID-19 risk perceptions of the public in Finland and to make this information readily available for those who communicate with the public during crises. The study is part of a larger project exploring crisis narratives through a mixed-methods approach. The study was based on a dataset of over 10,000 comments on the Facebook and Twitter posts of the Finnish Institute of Health and Welfare (THL) between March -May 2021. The data was analyzed qualitatively using thematic analysis. The study identified concepts linked with the pandemic risk perception that included knowledge, perceptions, personal experiences, trust, attitudes, and cultural values. The findings resulted in a framework of risk perceptions that can be used as taxonomy and a set of keywords to be used in social listening to monitor risk perception during future epidemics and pandemics.
Epidermal stem cell-derived exosomes alleviate autophagy induced endothelial cell apoptosis through miR200b-3p/ERK pathway in diabetic wounds
Authors: Xu hailin , Wang Zhiyong , Yang Hao , Chen Chufen , Dong Yunxian , Xu Zhongye , Lv Dongming , Wang Peng , Yuan Mingzhou , Wang Xiaoyan , Chen Miao , Tang Bing , Hu Zhicheng , Deng Wuguo , Zhu Jiayuan
Published: June 2022

Backgrounds: Diabetic wounds have the characteristics of abnormal inflammatory response, decreased neovascularization, and disturbed microenvironment. Clinical use of epidermal basal cell suspensions promotes chronic wound healing. Further study found that rat Epidermal stem cells (EpiSCs) could promote the angiogenesis of full-thickness wounds in SD rats. The mechanism of the effect of EpiSCs on wound healing warrants further study.Methods: In vivo, EpiSCs were labeled with enhanced green fluorescent protein and then sprayed on dorsal wound of db/db mice. The quality of wound healing was estimated by the residual wound area rate and Hematoxylin and Eosin (H&E) staining. Expression of neovascular markers and collagen formation were elucidated by immunohistochemistry (IHC), immunofluorescence (IF), and MASSOM.In vitro, the supernatant of EpiSCs were ultra-centrifugated to collected exosomes (EpiSC-EXOs). Human umbilical vein endothelial cells (HUVECs) were treated with high glucose and EpiSC-EXOs. miR 200b-3p is identified abundant in EpiSC-EXOs using RNA sequencing. HUVECs were analyzed with apoptosis rate, ROS level, proliferation and mitochondrial membrane potential.Results: In vivo, Epidermal stem cells (EpiSCs) could colonize in wounds, promoting angiogenesis thus accelerating wound healing in diabetic mouse model (db/db mouse). In vitro, EpiSC-EXOs had the ability to reduce apoptosis by downregulating excessive autophagy induced by high-glucose conditions. Furthermore, we found that miR200b-3p rich in EpiSC-EXOs affected the phosphorylation of ERK by targeting SYDE1 to regulate intracellular autophagy levels, thereby reducing vascular endothelial cell apoptosis caused by a high-glucose environment.Conclusions: Collectively, our results verified the effect of EpiSC-EXOs on apoptosis caused by a high-glucose environment in vascular endothelial cells and revealed that its underlying mechanism occurs through the miR200b-3p/SYDE1/RAS/ERK pathway. Our study explains the role of EpiSCs in promoting wound healing in diabetic patients.
Predicting IVF outcome in poor ovarian responders
Authors: Lebovitz Oshrit , Haas Jigal , Mor Nitzan , Zilberberg Eran , Aizer Adva , Kirshenbaum Michal , Orvieto Raoul , Nahum Ravit
Published: June 2022

Background
Poor responders to ovarian stimulation are one of the most challenging populations to treat. As a failed cycle can cause a considerable emotional and economical loss, adequate fertility counseling addressing patients’ expectations are highly important when facing patients with poor ovarian response. The study aimed to evaluate reproductive outcomes and to identify factors associated with live birth (LB) after fresh autologous IVF/ intracytoplasmic sperm injection (ICSI) cycles of patients fulfilling the Bologna criteria for poor ovarian response (POR).
Methods
A retrospective study included 751 IVF/ICSI treatment cycles which yielded up to three retrieved oocytes, at a tertiary referral hospital between January 2016 to February 2020. A logistic regression analysis was used to adjust for confounders.
Results
Clinical pregnancy and LB rate per cycle were significantly higher among women younger versus older than 40 years (9.8% and 6.8% versus 4.5% and 2.1%, p < 0.01, respectively). Patients who achieved LB were significantly younger, had higher number of oocytes retrieved, fertilization rate and top-quality embryos (P < 0.05). Multivariable regression analysis identified patient’s age (OR 0.90; 95% CI 0.845 to 0.97; p = 0.005) and mean number retrieved oocytes (OR 1.95; 95% CI 1.20 to 3.16; p = 0.007) as factors significantly associated with the probability of a LB.
Conclusions
The woman’s age and the number of retrieved oocytes are both independent predicting factors of live birth in poor ovarian responders. Considering the risks, the high financial investment and poor reproductive outcomes involved in IVF treatments, raises questions regarding the adequacy of providing treatments in these patients' population. POR younger than 40 years may represent a possible exception due to acceptable probability for a LB.
Influence of two supervised physical exercise programs on quality of life and depressive symptomatology: comparative analysis in three companies with sedentary occupations
Authors: Remón Ángel Luis Clemente , Díaz-Benito Víctor Jiménez , Díaz Sara Zafra , Jiménez-Beatty José Emilio , Moro María Isabel Barriopedro , Mateos María Espada , Lozano José Antonio Santacruz
Published: June 2022

The purpose of this paper is to assess the effect of two supervised physical exercise interventions in the workplace on quality of life and depressive symptomatology. A pre-experimental study was conducted on workers with sedentary occupations from three different companies and sectors: (1) Renewable energy engineering; (2) Insurance and (3) Infrastructure and services. The participants from the first two were administered a supervised physical exercise program in three Spanish corporate headquarters: Madrid, Navarre, the Basque Country and Madrid, respectively (PRODET→; n = 23; mean age 44.38 ± 4.91 years). The third company carried out another physical exercise intervention in a single corporate headquarters in Madrid (HASAVI; n = 27; mean age 39.25 ± 9.83). A pre- and post-test intragroup analysis of quality of life and depressive symptomatology was performed. The PRODETⓇ program found a reduction in body pain in workers at the Madrid headquarters of the renewable engineering company (p = 0.024; η2 = 0.18). In this same company, improvements in global physical health scores were found in the Navarre headquarters (p = 0.009; η2 = 0.40), as well as in the insurance company (p = 0.048; η2 = 0.10). An increase in general health was found in the Basque Country headquarters (p = 0.034; η2 = 0.33). The HASAVI program achieved a significant improvement in vitality (p = 0.041; η2 = 0.09). Both programs found a significant reduction in depressive symptoms in workers in the insurance and infrastructure and services company (p = 0.044; η2 = 0.12; p = 0.045; η2 = 0.10, respectively). The PRODETⓇ supervised physical exercise program could be effective in improving the quality of life of office employees in the sectors studied. Both programs could influence the decrease in depressive symptomatology.