bluuebunny/crossref_metadata_2025 huggingface dataset:
О глагольной специфике языка пехлевийской поэмы «Драхт-и Асуриг»
Authors:   Институт языкознания РАН, Виноградова С. П. , Баяндур А. С. ,   Институт археологии и этнографии НАН
Published: December 2022

Глагол «делать » в пехлевийской поэме «Драхт-и Асуриг » рядом исследователей рассматривается как «парфянизм ». Сравнительно- исторический анализ и привлечение языкового материала ряда живых бесписьменных северо- западных иранских языков и диалектов Центрального Ирана, а также диалектов зороастрийских и иудейских общин территорий, исторически входивших в «Большую Мидию », позволили рассматривать этот глагол в более широкой диалектной перспективе. Это позволило гипотетически реконструировать для мидийского языка ОНВ структуры *kar-//*kara, которая уже тогда могла быть закреплена за сферой презенса- имперфекта индикатива. The verb “to do” in the pahlavi poem “Draxt ī Āsūrīg” is regarded by some researchers as a Parthian. Its comparative historical analysis and usage linguisticdata from a number of living non-literate Northwestern Iranian languages and dialects of Central Iran, as well as dialects of the Zoroastrian and Jewish communities of the territories historically included in “Greater Media”, have made it possible to consider this Parthian-like word in a broader dialectal perspective. It is thus possible to hypothetically reconstruct the *kar-//*kara- structures for the Median present stem, which even in that case could be assigned to the sphere of the present-imperfect of the indicative.
L-carnitine and acetyl-L-carnitine enhance stallion sperm quality during semen storage at 5°C
Authors: Lisboa Fernando , Segabinazzi Lorenzo , Hartwig Felipe , Freitas-Dell`Aqua Camila , Papa Frederico , Dell`Aqua Jr José
Published: December 2022

Carnitine, a powerful antioxidant, has an essential role in sperm energy metabolism. Among carnitines, only L-carnitine’s effect on stallion semen has been tested and not acetyl-L-Carnitine. Therefore, we aimed to determine the ideal concentrations of L-carnitine (LC) and acetyl-L-carnitine (AC) and their effects on stallion semen cooled at 5℃ for up to 48 hours. Semen was extended to 50 x 106 sperm/ml in commercial extender (Control), and concentrations of 5, 10, and 15 mmol/l of LC and AC were evaluated in Experiment 1. Sperm motility and plasma membrane integrity were assessed by CASA and epifluorescence microscopy, respectively. In Experiment 2, the combination of the intermediate doses of LC (10 mmol/l) and AC (10 mmol/l) was tested. Sperm parameters were evaluated as in Experiment 1 and in addition, DNA fragmentation index (DFI), production of reactive oxygen species (ROS), and lipid peroxidation (PEROX) were evaluated by flow cytometry. All analyses were performed at 0, 24, and 48 hours after semen collection, processing, and cooled-stored at 5°C. In Experiments 1 and 2, the groups supplemented with LC and AC or LC+AC had higher plasma membrane integrity and motility parameters compared to Control group (p < 0.05). The LC and AC combination did not change sperm parameters compared to LC or AC alone (p > 0.05). No differences (p > 0.05) were observed for DFI, ROS, and PEROX. In conclusion, LC and AC’s addition, alone or in combination, enhanced sperm motility and plasma membrane integrity of stallion sperm after cooled-storage at 5℃ for up to 48 hours.
A case of unilateral hydrocele in a dog secondary to inapparent inguinal hernia
Authors: Draheim Peyton , Hlusko Katelyn , Cole Robert , Douglas Jamie , Withers Cornelius , Graff Emily , Wilborn Robyn
Published: December 2022

A 6-year, male intact Coonhound, was presented for unilateral scrotal enlargement of roughly 3 months’ duration. His left side scrotum was markedly enlarged and edematous and both testes palpated normal. Rapid slide agglutination test (for brucellosis) and SNAP 4DX (IDEXX Laboratories, Inc., Westbrook, ME) test (for tick-borne disease) were negative. Initial scrotal ultrasonography revealed accumulation of anechoic fluid with hyperechoic flecks and swirling surrounding the left testis. On further ultrasonographic examination, omentum appeared extending through the left inguinal ring and into the scrotum. A case of scrotal hernia with secondary hydrocele was diagnosed. Hydrocele was resolved surgically and the dog returned to full athletic function.
Ovarian remnant syndrome in small animals: case series
Authors: Mullikin Kiki , Byron Michael , Chen Janice , Cheong Soon Hon , Gartley Cathy , Diel de Amorim Mariana
Published: December 2022

Our objective was to report the utility of various diagnostic tests in identifying ovarian remnant syndrome (ORS) in dogs and cats. Medical records from 2 referral teaching hospitals (Health Sciences Centre at the Ontario Veterinary College and Cornell University Hospital for Animals) were examined and 48 animals (31 dogs and 17 cats) were chosen. Data included were based on sufficient clinical or diagnostic evidence of ORS. Histopathology was used as the confirmatory test for ORS. There was no difference between the proportions of dogs versus cats diagnosed with ORS. Similarly, there was no difference in the proportions of ovarian remnants (OR) between large, medium, or small dogs, or the side (right, left, or bilateral) in which OR was diagnosed. Vaginal cytology and transabdominal ultrasonography findings, and serum progesterone concentrations had the highest chance of correctly identifying an OR prior to exploratory surgery. Transabdominal ultrasonography had strong agreement with OR location identified at surgery. Presumptive intraoperative diagnosis of OR was possible in 39/41 cases (95.1%). Auxiliary diagnostic testing should be recommended to confirm functional ovarian tissue before surgery to reduce unnecessary surgery. Additionally, transabdominal ultrasonography examination may reduce surgical time since ovarian remnant location has strong agreement with surgical findings.
Intromission failure in a stallion
Authors: Kelley Dale , Roscoe Justin , Wittorff Alex , Bassett Adam , Pinaffi Fabio , Holyoak Reed
Published: December 2022

Determining the cause of poor libido in stallions can be challenging. Many factors can cause disturbance in libido (e.g., lameness or physical pain, hormonal, age, experience, and handling). Identifying the cause of poor libido is important to determine the best treatment approach. A 6-year Thoroughbred stallion was presented for failure of intromission when attempting to breed mares. Stallion was recently retired from racing. Stallion was placed on hormonal therapy that did not change stallion’s aberrant reproductive behavior. On presentation no obvious physical causes were identified and the stallion displayed masturbation behavior. Through the review of video recordings of the breeding sessions, modifications were made that eventually resulted in the stallion successfully breeding mares without hormonal intervention. This case illustrated how video recordings of breeding activity can help in determining cause of reproductive dysfunction. Furthermore, interpretation of peripheral steroid hormone concentrations needs to be carried out with caution.
Bimbingan Teknis Peliputan Berita Dan Pengelolaan Website
Authors: Syafrul Syafrul Irawadi , Maya Maya Saftari , Iswanto Yuni , M Ahmad Rosydian , Sariman Sariman
Published: December 2022

Bawaslu Propinsi Kepulauan Bangka Belitung sebagai badan pengawas pemilu yang ada di propinsi Bangka Belitung juga mengganggap penting untuk memberikan informasi dan pengelolaan website dengan benar. Untuk itu, Bawaslu bekerjasama dengan perguruan tinggi dan pemerintah mengadakan bimbingan teknis dan pelatihan bagi pengelola pemberitaan dan website guna meningkatkan kemampuan pengelola. Pelatihan dan bimbingan teknis ini melibatkan para narasumber yang ahli dibidangnya  yang berasal dari berbagai instansi. STMIK Atma Luhur sebagai perguruan tinggi mengakomodasi kegiatan pelatihan dengan melibatkan tim pengabdian kepada masyarakat (PKM). Tim PKM terdiri dari 3 orang dosen dan 2 orang mahasiswa.  Kegiatan berlangsung pada tanggal 7 Desember 2019 yang bertempat di Grand Vella Hotel Bangka. Peserta pelatihan berasal dari  7 kabupaten/kota dengan masing-masing kabupaten mengirimkan 3 orang perwakilan dari Bawaslu kabupaten/kota. Kegiatan pelatihan dimulai dari pagi hingga sore hari. Metode dalam kegiatan PKM ini adalah pelatihan dan bimbingan teknis dengan metode ceramah dari para narasumber. Dalam pelaksanaan kegiatan selain materi yang diberikan, juga diadakan kegiatan praktek untuk mendemonstrasikan  cara pengelolaan website dengan baik dan teknis-teknis peliputan berita untuk memberikan informasi yang baik dan benar. Hasil evaluasi kegiatan bimbingan  dan praktek yang dilakukan, diketahui bahwa peserta mendapatkan ilmu dan pengetahuan yang dapat meningkatkan kemampuan dalam pengelolaan pemberitaan dan website Bawaslu.
Mathematical Learning Based on Multymedia at MTs Sabilul Muhtadin, Bangka District
Authors: - Euis Asriani , Amelia Ririn
Published: December 2022

Kegiatan pengabdian masyarakat ini bertujuan untuk meningkatkan motivasi siswa MTS Sabilul Muhtadin dalam pembelajaran matematika berbasis multimedia. Pendekatan ini dipilih dengan tujuan untuk menyajikan pembelajaran dalam bentuk yang menyenangkan, menarik, mudah dimengerti, dan jelas. Adapun peserta kegiatan adalah siswa kelas VIII yang berjumlah 30 (tiga puluh) orang. Untuk mengetahui efektifitas pendekatan ini disebarkan angket/kuesioner sesudah pembelajaran dilaksanakan. Data yang terkumpul selanjutnya dianalisis menggunakan statistika deskriptif dalam bentuk diagram pie. Pada aspek kepuasan pelaksanaan pembelajaran, persentase tertinggi terletak pada  kelompok yang merasa puas yakni sebesar 70%. Pada aspek ketertarikan terhadap pembelajaran, sebanyak 66.67% menyatakakan sangat tertarik terhadap pembelajaran berbasis multimedia. Adapun pada aspek motivasi, semangat, dan keaktifan, persentase tertinggi terdapat pada kelompok termotivasi, semangat, dan aktif, yakni masing-masing sebesar 60%.  Melalui kegiatan ini dapat disimpulkan bahwa pelaksanaan pembelajaran matematika berbasis multimedia secara umum menumbuhkan kepuasan, ketertarikan, semangat, keaktifan,  motivasi belajar, dan pemahaman siswa.
Pelatihan Bahasa Inggris Dan Seni Tari Bagi Remaja Masjid Tahfidz Al Qur'an Nurul Huda Di Nagari Panyalaian
Authors: Ardiel Vonny , Sa’danoer Ira Maulina , Tyas Dina Ayuning
Published: December 2022

Keterampilan berbahasa Inggris merupakan sebuah Keterampilan yang sangat dibutuhkan dalam era globalisasi ini. Bahasa Inggris merupakan alat komunikasi utama dalam pendidikan maupun interaksi umum dalam masyarakat nasional maupun Internasional. Pelatihan bahasa Inggris untuk remaja Tahfidz Markazul Quran mushola Nurul Huda Nagari Panyalaian merupakan salah satu bentuk referensi ilmu dalam upaya program Babaliak ka Surau. Pelatihan bahasa Inggris ini menggunakan metode Gamification, dimana proses pembelajarannya menggunakan metode permainan tebak kata, angka, gambar dan kata. Tujuan penggunaan metode ini adalah untuk menimbulkan rasa senang dan tidak bosan dalam belajar, kemudian dapat menarik minat dan motivasi peserta dalam belajar. Begitu juga dengan pelatihan tari tradisional pasambahan sebagai sebuah program untuk melestarikan dan mempertahankan seni budaya Minangkabau. Hasil dari kegiatan ini adalah (1) peningkatan minat dan motivasi dalam mempelajari Bahasa Inggris. (2) Dapat menambah kosakata dalam kehidupan sehari-hari (3) Dapat menggunakan bahasa Inggris dasar dalam komunikasi (3) peningkatan keterampilan seni budaya khususnya tari tradisional. Evaluasi kegiatan ini menunjukkan bahwa kegiatan ini mendapatkan dukungan dari peserta pelatihan dan pengurus mushola dan akan menjadi program lanjutan bagi tim. Oleh karena itu program ini merupakan bentuk penggiatan program Ba Baliak ka Surau untuk remaja Nagari Panyalaian.
Character Recognition Techniques and approaches: a literature review
Authors: Mostafa Abdulghfoor Mohammed  , Shuyuan Yang
Published: December 2022

Researchers have carried out many approaches to recognizing the OCR through software-based and FPGA-based and its relationship with the ANNs and training these NNs by using the BP algorithm. The FPGA supports high speed to recognize the character because it works in parallel. It involves many logic circuits and can process at the same time (clock cycle). There have been problems with the established system because the size, shape, and style of supposedly identical characters might differ from person to person and even within the same person on rare occasions. The photograph is vulnerable to noise and can lose some or all of its visual clarity as a result.  There are strict guidelines that govern the way a character looks that the character must adhere to. The NN and its learning process could only be defined by heuristically deducing its rules from samples and the enormous dataset.
Escuela Normal de Oaxaca. An approach to the history of teacher training in Southern México, 1890-1937
Authors: Traffano Daniela
Published: December 2022

Al iniciar su devenir como nación independiente, México hizo de la educación uno de sus objetivos centrales en la meta de integrar a una sociedad heterogénea. En el estado de Oaxaca, estas intenciones llevaron a múltiples iniciativas y legislaciones que buscaron formar preceptores que llevaran la ilustración a todos los rincones de su agreste geografía; los planes chocaron casi siempre con la bancarrota de la administración y con múltiples conflictos políticos que impidieron la cristalización del esfuerzo. El presente trabajo analiza el periodo más estable de este complejo proceso, el que inicia en 1890 y concluye en un periodo turbulento, luego de los reacomodos revolucionarios, en 1937, cuando la entidad cedió la responsabilidad educativa a la federación.
“Labores propias de su sexo”: el trabajo de aguja y la educación femenina en España en el siglo XIX. Domesticidad, profesión artística y construcción de género
Authors: Hernández Clara
Published: December 2022

En este trabajo se analiza cómo la asociación entre feminidad y labores de aguja fue un importante elemento en el proceso de construcción del género del siglo XIX y cómo esta vinculación generó una relación conflictiva entre el trabajo de aguja y la profesionalización. Para ello, se estudia, en primer lugar, el papel de las labores de aguja en la educación de las niñas, así como su asimilación a la naturaleza femenina y a la moralidad. En segundo lugar, su uso en la configuración de la feminidad a partir de la cultura visual y material. Por último, el aspecto profesional del trabajo de la aguja, adoptando una perspectiva amplia que incluye el trabajo industrial, artesanal y artístico junto con su valoración en el marco del trabajo femenino.
Depuración y exilio interior de las maestras de primera enseñanza en el Madrid de posguerra
Authors: Ramos Zamora Sara , Santiesteban Andra
Published: December 2022

La depuración del magisterio representa un ejemplo de incautación de la memoria disidente, de aquella memoria que permaneció alejada de los discursos de legitimación del régimen franquista, llevando a cabo numerosas medidas para garantizar un proceso progresivo de des-memorización colectiva y de contra-memoria en una sociedad abatida por la guerra. Al mismo tiempo, el Nuevo Estado puso en marcha distintos criterios y mecanismos a la hora de evaluar, valorar y decidir finalmente sobre el futuro profesional de los docentes en función del género. Las maestras fueron objeto de una represión sexuada. Existe una importante producción bibliográfica sobre estudios que abordan la depuración del magisterio primario en España. Este artículo pretende cubrir una laguna aún presente en la historiografía educativa, como es el estudio de este proceso en la provincia de Madrid, centrándonos en el colectivo de maestras. Se pone de manifiesto cómo el proceso depurativo se desarrolló con algunas peculiaridades que no se dan en otras provincias españolas y, aunque los rasgos generales del desarrollo del procedimiento son similares, las maestras madrileñas serán menos castigadas que en otras regiones de la península.
Piety and privilege: catholic secondary schooling in ireland and the theocratic state, 1922-1967, by Tom O’ Donoghue and Judith Harford
Authors: Lyons Tony
Published: December 2022

Review of the book Piety and privilege: catholic secondary schooling in ireland and the theocratic state, 1922-1967, by Tom O’ Donoghue and Judith Harford
Niñas y niños vigilados. La preparación para la sexualidad en Colombia y España en la primera mitad del siglo XX, por Federico Guillermo Serrano López
Authors: Seoane Cegarra José Benito
Published: December 2022

Reseña del libro FEDERICO GUILLERMO SERRANO LÓPEZ. Niñas y niños vigilados. La preparación para la sexualidad en Colombia y España en la primera mitad del siglo XX. Madrid: UNED y Universidad del Norte, 2022
Memoria y experiencia de la educación bajo el franquismo (1957-1972), by Guillermo Castán Lanaspa
Authors: Cuesta Fernández Raimundo
Published: December 2022

Review of the book by GUILLERMO CASTÁN LANASPA. Memoria y experiencia de la educación bajo el franquismo (1957-1972). Salamanca: Ediciones de la Universidad de Salamanca, 2022
Velocity Prediction Program for a Hydrofoiling Lake Racer
Authors: Melis Michele Francesco , Hansen Heikki , Fischer Martin , Abdel-Maksoud Moustafa
Published: December 2022

The aim of this paper is to develop an accurate and robust six degrees of freedom stationary velocity prediction program (VPP) applied to a high-performance sailing yacht. The model is set up to assist NC Raceboats with the VPP based hydrofoil design, considering the sailing performance in three modes: displacement, transition and hydrofoil. The yacht is a lightweight monohull designed for light wind conditions with up to five crew members. The design includes a self-stabilizing hydrofoil configuration and an elevator rudder. The software tool, which is used for the velocity prediction program, is FS-Equilibrium, developed by DNV. The software offers a modular workbench in which each force can be modelled with semi-empirical force modules, which are based on validated methods and theories. The performance prediction is interpreted and discussed: as foreseen, the performance of the high-performance lake racer in hydrofoiling condition is significantly improved compared to its assessment in displacement sailing mode. In medium breeze conditions, the yacht is able to lift up on its hydrofoils and attain flight mode. The minimum hydrofoiling speed investigation demonstrates that the VPP is able to consistently iterate Through the transition mode. This paper shows that it is possible to develop a VPP model for a hydrofoiling sailing yacht on the basis of relatively simple assumptions and theories.
Teodora y el feminismo jurídico en Bizancio. María José Bravo Bosch, Tirant Lo blanch, Valencia, 2021, 320 pp. ISBN: 978-84-1397-971-7
Authors: Barcia Lago Modesto
Published: December 2022

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Religión y cultos en la Meseta sur de Hispania durante época romana. Carrasco Serrano, G. (Coord.), Cuenca, 2021, 373 pp. ISBN: 978-84-9044-446-7
Authors: Palencia García Juan F.
Published: December 2022

Se estudia toda la religiosidad romana en la Meseta Sur de la Península Ibérica por varios autores especialistas.
Evaluation of the level of Internet Addiction and its effects on academic performance among Medical and Paramedical College Students in Iraq
Authors: Kamil Amel Mustafa , Yousif Dina Khalid
Published: December 2022

Introduction: Nowadays a considerable population in the world uses the internet. Unfortunately, despite many interests and its specific advances in communication, the Internet is sentenced to have serious side effects. Objective: To detect the percentage of internet addiction and its effect on academic performance among Medical and Paramedical students in some Iraqi universities. Methods: A cross-sectional study was conducted among 806 medical and paramedical students who were subjected to the online survey which includes demographic information associated with internet usage, and Young's Internet Addiction Test (YIAT) was applied to survey the grade of internet addiction. Results: Results reveal a moderate level of addiction among students without significant variations between genders, high significant relationship (p<0.01) between students concerning their housing area, and strong significant variations (p<0.01) in the time of using the internet, besides strong significant differences (p<0.01) between internet addiction and academic performance. Conclusion: Medical and paramedical students practice the internet for diverse activities including learning despite their moderate grade of addiction there are no significant differences between genders. They employ it over 5 h/day, which affects negative tasks on their academic performance.
Qualidade de vida relacionada à saúde de pacientes submetidos à correção de valvopatias
Authors: Maier Suellen Rodrigues de Oliveira , Fernandes Paolla Algarte , Dessotte Carina Aparecida Marosti
Published: December 2022

Introdução: A mensuração do constructo qualidade de vida relacionada à saúde pode revelar as repercussões positivas na vida dos pacientes submetidos a procedimentos valvares corretivos, bem como revelar pontos que para prevenção de novas abordagens cirúrgica. Objetivo: Identificar a qualidade de vida relacionada à saúde de valvopatas no perioperatório de intervenção cirúrgica valvar convencional. Método: Trata-se de uma revisão integrativa da literatura. As buscas foram realizadas de forma independente, em quatro bases de dados por meio de descritores controlados e não controlados. Os critérios de elegibilidade foram: artigos originais que abordassem a avaliação da qualidade de vida relacionada à saúde de valvopatas submetidos à plastia valvar e/ou implante de prótese valvar; nos idiomas português, inglês e espanhol; com recorte temporal por conveniência entre 2015 e 2019. Resultados: 14 estudos compuseram a amostra final da revisão, apesar de serem estudos realizados em distintos países e com diferentes delineamentos foi possível verificar a melhora da qualidade de vida relacionada à saúde quando avaliada por meio de instrumentos genéricos em valvopatas após a intervenção cirúrgica valvar. Todavia, nos estudos em que a avaliação do constructo ocorreu por meio de instrumentos específicos, foi revelada a existência de fatores que podem interferir na qualidade de vida dos pacientes submetidos aos implantes valvares. Conclusão: Percebeu-se que geralmente houve melhora da qualidade de vida relacionada à saúde após a intervenção cirúrgica.
Dal voto alla valutazione per l’apprendimento
Authors: Corsini Cristiano , Gueli Carla
Published: December 2022

This paper returns the outcomes of a research-training project, as result of the collaboration between university researchers and teachers and principals of a network of schools in Lazio. Research-training is a way of doing empirical research that, making use of differentiated methodologies aims to develop teaching professionalism through the construction of research paths agreed between universities and schools. The present investigation started from a training need made explicit by schools: the need to develop skills useful for dealing with the transition from grades to judgments. A synthesis of teachers’ diverse views on assessment and perceptions of change is proposed here. The reflection and evidence gathered can help to prefigure the direction to be taken to overcome the risk that the use of feedback or levels may trace a construct that refers to the grade, de-emphasizing or effectively nullifying its value. Feedback and restitution, on the other hand, are tools of a motivating design that aims to provide learners with guidance for understanding and analysing their own learning and support for making effective and conscious choices in organising future learning.
Construction and Validation of Emotional Intelligence Scale for Secondary School Teachers
Authors: Dey Antara , Roy Nil
Published: December 2022

In this study, we developed and validated a new instrument: an emotional intelligence scale for teachers. This paper focused on the psychometric properties of the emotional intelligence scale for school teachers dealing with adolescent students. The study also validated the tool over 608 secondary school teachers in India. This scale was evaluated using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), Cronbach’s alpha, and item-total correlation. Results showed good fit (χ2/df =1085.66, CFI = 0.956, GFI = 0.876, TLI = 0.951, PCFI = 0.860, PNFI = 0.843, RMSEA = 0.06 and SRMR = 0.056) for the five components (Self-Perception, Self-Regulation, Self-Drive, Empathy, Social Motive) of the measurement model. However, 80.18% of the total variance was explained by the factors Reliability (Cronbach alpha = 0.95) and construct validity means convert and discriminant validity was established for a teacher’s innovative emotional intelligence scale. Finally, the robust findings indicated that the instrument could be used in further studies in different research areas.
Endovascular recanalization therapy for patients with acute ischemic stroke with hidden aortic dissection: A case series
Authors: Jeong Hye Seon , Jeong Eun-Oh , Lee In Young , Lee Hak In , Koh Hyeon-Song , Kwon Hyon-Jo
Published: December 2022

Aortic dissection is one of the causes of acute ischemic stroke. Endovascular recanalization therapy (EVT) has emerged as an essential treatment for acute ischemic stroke due to large artery occlusion. However, it is rarely performed in the situation of hidden aortic dissection (AD). Two patients presented to the emergency room with focal neurologic deficits. The first patient was diagnosed with right internal carotid artery (ICA) occlusion. Angiography revealed that the ICA was occluded by the dissection flap. After a stent deployment in the proximal ICA, the antegrade flow was restored. The patient was diagnosed with AD on chest computed tomography (CT) after EVT. For the second patient, intraarterial thrombectomy was performed to treat left middle cerebral artery occlusion. AD was first detected on echocardiography, which was performed after EVT. Herein, we report successful endovascular recanalization therapy performed in two patients with acute ischemic stroke in the situation of undiagnosed aortic dissection. We also reviewed previous case reports and relevant literature.
A new diagnostic method for chronic obstructive pulmonary disease using the photoplethysmography signal and hybrid artificial intelligence
Authors: Melekoglu Engin , Kocabicak Umit , Uçar Muhammed Kürşad , Bilgin Cahit , Bozkurt Mehmet Recep , Cunkas Mehmet
Published: December 2022

Background and Purpose

Chronic obstructive pulmonary disease (COPD), is a primary public health issue globally and in our country, which continues to increase due to poor awareness of the disease and lack of necessary preventive measures. COPD is the result of a blockage of the air sacs known as alveoli within the lungs; it is a persistent sickness that causes difficulty in breathing, cough, and shortness of breath. COPD is characterized by breathing signs and symptoms and airflow challenge because of anomalies in the airways and alveoli that occurs as the result of significant exposure to harmful particles and gases. The spirometry test (breath measurement test), used for diagnosing COPD, is creating difficulties in reaching hospitals, especially in patients with disabilities or advanced disease and in children. To facilitate the diagnostic treatment and prevent these problems, it is far evaluated that using photoplethysmography (PPG) signal in the diagnosis of COPD disease would be beneficial in order to simplify and speed up the diagnosis process and make it more convenient for monitoring. A PPG signal includes numerous components, including volumetric changes in arterial blood that are related to heart activity, fluctuations in venous blood volume that modify the PPG signal, a direct current (DC) component that shows the optical properties of the tissues, and modest energy changes in the body. PPG has typically received the usage of a pulse oximeter, which illuminates the pores and skin and measures adjustments in mild absorption. PPG occurring with every heart rate is an easy signal to measure. PPG signal is modeled by machine learning to predict COPD.

Methods

During the studies, the PPG signal was cleaned of noise, and a brand-new PPG signal having three low-frequency bands of the PPG was obtained. Each of the four signals extracted 25 features. An aggregate of 100 features have been extracted. Additionally, weight, height, and age were also used as characteristics. In the feature selection process, we employed the Fisher method. The intention of using this method is to improve performance.

Results

This improved PPG prediction models have an accuracy rate of 0.95 performance value for all individuals. Classification algorithms used in feature selection algorithm has contributed to a performance increase.

Conclusion

According to the findings, PPG-based COPD prediction models are suitable for usage in practice.
Identification and validation of a ferroptosis-related lncRNA signature to robustly predict the prognosis, immune microenvironment, and immunotherapy efficiency in patients with clear cell renal cell carcinoma
Authors: Ju Lincheng , Shi Yaxing , Liu Gang
Published: December 2022

Background

Ferroptosis is a new type of iron- and reactive oxygen species-dependent cell death, studies on ferroptosis-related long noncoding RNAs (FerLncRNAs) in clear cell renal cell carcinoma (ccRCC) are limited. The purpose of this study was to investigate the potential prognostic value of FerLncRNAs and their relationship with the immune microenvironment and immunotherapy response of ccRCC.

Methods

RNA sequencing data of 526 patients with ccRCC were downloaded from The Cancer Genome Atlas (TCGA) database. The patients with ccRCC in TCGA were randomly divided (1:1) into a training and testing cohort. ICGC and GEO databases were used for validation. Screening for FerLncRNAs was performed using Pearson’s correlation analysis with the reported ferroptosis-related genes. A FerLncRNA signature was constructed using univariate, LASSO, and multivariate Cox regression analyses in the training cohort. Internal and external datasets were performed to verify the FRlncRNA signature. Four major FRlncRNAs were verified through in vitro experiment.

Results

We identified seven FerLncRNAs (LINC00894, DUXAP8, LINC01426, PVT1, PELATON, LINC02609, and MYG1-AS1), and established a risk signature and nomogram for predicting the prognosis of ccRCC. Four major FRlncRNAs were verified with the prognosis of ccRCC in the GEPIA and K-M Plotter databases, and their expressions were validated by realtime PCR. The risk signature can also effectively reflect the immune environment, immunotherapy response and drug sensitivity of ccRCC. These FRlncRNAs have great significance to the implementation of individualized treatment and disease monitoring of ccRCC patients.
BASE NACIONAL COMUM CURRICULAR E O SETOR PRIVADO NA EDUCAÇÃO: uma relação de colaboração?
Authors: Carvalho Bia , Ramos Géssica Priscila
Published: December 2022

O presente artigo tem como objetivo fazer uma análise inicial sobre a Base Nacional Comum Curricular (BNCC) e seu processo de elaboração, observando se estes trouxeram contribuições para a atuação do setor privado na educação pública. A Base teve o seu processo de construção permeado por debates e críticas e, para compreender esse contexto, estudamos o seu processo de elaboração e a relação estabelecida entre ele e os grupos empresariais. Utilizamos como procedimentos metodológicos, a análise bibliográfica com suporte documental. Os resultados demonstram que a Base contribuiu para a ampliação da inserção do setor privado na educação básica, a partir de elementos internos à ela, além de fortalecer e ampliar as possibilidades no “mercado” educacional.
Palavras-chave: Base Nacional Comum Curricular. Setor Privado. Política Educacional.
Induction of Apoptosis in Ehrlich Ascites Carcinoma Cells Through An Intrinsic Pathway by Co(II)-benzoin Thiosemicarbazone Complex [Co(BTSC)2]
Authors: Zakir Hossain Mohammad , Sarker Md. Murshed Hasan , Shariar Sha Md. Shahan , Jesmin Mele , Mohsin Ali Shaikh M.
Published: December 2022

A group of cells exhibit uncontrolled proliferation, invasion, and occasionally metastasis in cancer, a category of disorders. According to statistics, cancer is the second largest cause of mortality in the world. As a result, current cancer research places a strong priority on the discovery and development of novel, effective, and selective anticancer medications. The purpose of this work was to determine the method by which Ehrlich ascites cancer (EAC) cells are inhibited by Co(II)-benzoin thiosemicarbazone complex in Swiss albino mice. DNA fragmentation assays and nuclear morphology observations both supported the induction of apoptosis in EAC cells. The mRNA expression levels of many tumor-related antiapoptotic genes, including B-cell lymphoma 2 (bcl-2), B-cell lymphoma extra-large (bcl-xL), and caspase-8, as well as proapoptotic genes, including p53 or tumor protein, bcl-2 associated X protein (bax), caspase-9, caspase-3, and poly-ADP ribose polymerase (PARP-1) and in vitro effect of caspase inhibitors on EAC cells.   Using 2', 7'- dichlorodihydrofluorescein diacetate (DCFH-DA) staining, reactive oxygen species (ROS) production following Co(BTSC)2 treatment were quantified. The findings of this investigation revealed that the induction of apoptosis by Co(BTSC)2 occurred via an intrinsic mitochondria-mediated ROS-dependent mechanism as opposed to an extrinsic one, and that this intrinsic pathway was controlled by the bcl-2 protein family. As a result, this study offers support for conducting more research to develop novel anticancer drugs.
Gibberellic Acid Enhances the Germination and Growth of Maize under Salinity Stress
Authors: Rauf Farjana , Ullah Md. Ahsan , Kabir Muhammad Humayun , Mia Md. Ashik , Rhaman Mohammad Saidur
Published: December 2022

Soil salinity is the major limiting factor restricting plant growth and development. Little is known about the comparative and combined effects of gibberellic acid (GA3) seed priming and foliar application on maize under salt stress. The current study determined the impact of different concentrations of GA3 on morpho-physiological and photosynthetic attributes of maize seedlings under salinity stress treatments (no salinity and severe salinity-15 dSm-1). The GA3 treatments consisted of 1mM, 2mM, 3mM, 4mM and 5mM GA3 seed priming and exogenous application in salt condition. Salt stress particularly at 15 dSm-1 reduced the length of shoots and roots, fresh and dry weights, chlorophyll, lycopene, beta-carotine and carotenoid contents in maize plants. Nevertheless, the application of GA3 improved maize growth under salt stress. Compared with salt, the 2mM GA3 treatment (T4) recorded the highest increase in roots and shoots length, roots fresh and dry weights, shoots fresh and dry weights, chlorophyll content under salt stress compared to other concentrations. These results indicated that 2mM GA3 priming and exogenous application could be used as an effective tool for improving the maize growth and development in salt contaminated soils.
Influence of Growth Retardants on Vegetative Growth of Apple (Malus × domestica Borkh.) Cultivars under High Density Planting System
Authors: Ahad Shabnam , Simnani Shamim A. , Sharma M. K. , Mir Shakeel A. , Bhat S. A. , Murtaza Imtiyaz , Mumtaz Sumaya , Ashraf Shahida , Hamid Mehnigar , Majid Insha
Published: December 2022

The present investigation entitled “Regulation of growth, fruiting and biochemical characteristics in Fuji Zehn Aztec and Red Braeburn apple cultivars through application of growth retardants under high density planting system” was conducted in the Experimental Block of the Division of Fruit Science at Sher-e-Kashmir University of Agricultural Sciences & Technology of Kashmir, Shalimar campus, Srinagar (J&K) during the years 2020 and 2021. Four-year-old apple cultivars Fuji Zehn Aztec and Red Braeburn on M9-T337 planted at a distance of 3×1 meter of uniform age, vigor and girth were used for the study. The experiment comprising of seven treatments viz., control, prohexadione-calcium @125 ppm, prohexadione-calcium @250 ppm, prohexadione-calcium @500 ppm, paclobutrazol @200 ppm, paclobutrazol @400 and paclobutrazol@600 ppm was laid out in randomized complete design with three replications. The chemicals were sprayed one week after petal fall, three weeks after 1st spray and three weeks after 2nd spray. Paclobutrazol@600 ppm resulted in maximum reduction in vegetative growth parameters in both the apple cultivars under study.
Comparative Pharmaceutico-analytical Study of Shilajatu Collected from Himachal Pradesh with that Samples Obtained from Standard Commercial Sources and their In-vitro Antioxidant Study- A Study Protocol
Authors: Thakur Sudarshan K. , Rathi Bharat , Rathi Renu , Tak Anjna , Soni Manik
Published: December 2022

Background: Shilajatu is one among the most used and important drugs in Ayurveda. However, a big percentage of Shilajatu samples available in market is not genuine. The analytical standards of Shilajatu are still not in Ayurvedic pharmacopoeia or any authoritative publication. So, the characterization and standardization of Shilajatu is required. Moreover, Shilajeet is vaguely being used by the layman and even professionals. It’s therapeutic potential needs to be specifically evaluated. 

Aims: To compare pharmaceutico-analytical characteristics of Shilajatu collected from Himachal Pradesh with that samples obtained from standard commercial sources and their in-vitro antioxidant study.

Methodology: The collection of samples from the site near Rampur Bushahr, Himachal Pradesh will be done in favourable season (in the month of April to June and September-October) by personal visits. The samples of Shilajatu from two sites shall be taken for this study. Two market samples shall also be bought from two standard commercial sources. All the samples shall be taken in triplicate to ensure data accuracy. Minimum 4 sources samples in triplicate, so total minimum 12 raw samples shall be taken. Further analysis of raw samples then pharmaceutical processing (Shodhana) and again analysis of processed samples shall be done. In analysis organoleptic, Physico-Chemical, elemental analysis and estimation of Humic acid and Fulvic acid shall be done of minimum 12 Raw samples and 12 processed samples (total minimum 24 samples). In-Vitro antioxidant study shall be done for both sources, processed samples.

Observations & Results: The observations noted while collection, analysis, processing of all samples shall be documented and presented in the form of data, photographs, tables, chart, etc. as applicable.  Further the processed Shuddha Shilajeet shall be subjected to an In-Vitro antioxidant study. Findings will be analyzed for interpretation of results.

Conclusion: A comparative data of samples of Shilajatu, collected from site of natural occurrence and standard commercial sources, with respect to pharmaceutical work, analysis and In-Vitro antioxidant study will be generated.
A 62-Year-Old Woman With a Large Abdominal Mass
Authors: Marano Luigi , Carbone Ludovico , Roviello Franco
Published: December 2022

A 62-year-old nulligravida woman had 10 months of progressive abdominal distension, diffuse abdominal pain, and 25-kg weight gain. She had no nausea or vomiting, hematochezia, or stool changes; pelvic and abdominal examination showed a large abdominal mass extending from the epigastrium to the pelvis but no other abnormalities; results of laboratory testing, including cancer antigen levels, were unremarkable. What is the diagnosis and what would you do next?
Changes in Physician Work Hours and Implications for Workforce Capacity and Work-Life Balance, 2001-2021
Authors: Goldman Anna L. , Barnett Michael L.
Published: December 2022

Importance

Physician work hours are an underexplored facet of the physician workforce that can inform policy for the rapidly changing health care labor market.

Objective

To examine trends in individual physician work hours and their contribution to clinical workforce changes over a 20-year period.

Design, Setting, and Participants

This cross-sectional study focused on active US physicians between January 2001 and December 2021 who were included in the Current Population Survey. Outcomes for physicians, advanced practice professionals (APPs), and nonphysician holders of doctoral degrees were compared, and generalized linear models were used to estimate differences in time trends for weekly work hours across subgroups.

Main Outcomes and Measures

Physician and APP workforce size, defined as the number of active clinicians, 3-year moving averages of weekly work hours by individual physicians, and weekly hours contributed by the physician and APP workforce per 100 000 US residents.

Results

A total of 87 297 monthly surveys of physicians from 17 599 unique households were included in the analysis. The number of active physicians grew 32.9% from 2001 to 2021, peaking in 2019 at 989 684, then falling 6.7% to 923 419 by 2021, with disproportionate loss of physicians in rural areas. Average weekly work hours for individual physicians declined by 7.6% (95% CI, −9.1% to −6.1%), from 52.6 to 48.6 hours per week from 2001 to 2021. The downward trend was driven by decreasing hours among male physicians, particularly fathers (11.9% decline in work hours), rural physicians (−9.7%), and physicians aged 45 to 54 years (−9.8%). Physician mothers were the only examined subgroup to experience a statistically significant increase in work hours (3.0%). Total weekly hours contributed by the physician workforce per 10 000 US residents increased by 7.0%, from 13 006 hours in 2001 to 2003 to 13 920 hours in 2019 to 2021, compared with 16.6% growth in the US population over that time period. Weekly hours contributed by the APP workforce per 100 000 US residents grew 71.2% from 2010 through 2012 to 2019 through 2021.

Conclusions and Relevance

This cross-sectional study showed that physician work hours consistently declined in the past 20 years, such that physician workforce hours per capita lagged behind US population growth. This trend was offset by rapid growth in hours contributed by the APP workforce. The gap in physician work hours between men and women narrowed considerably, with diverging potential implications for gender equity. Increasing physician retirement combined with a drop in active physicians during the COVID-19 pandemic may further slow growth in physician workforce hours per capita in the US.
Association Between Patient Satisfaction With Their Patient-Physician Relationship and Completion of Bariatric Surgery by Race and Ethnicity Among US Adults
Authors: Xie Luyu , Almandoz Jaime P. , Mathew M. Sunil , Schellinger Jeffrey N. , Kapera Olivia , Ngenge Sophia , Marroquin Elisa Morales , McAdams Carrie , Kukreja Sachin , Schneider Benjamin , Messiah Sarah E.
Published: December 2022

Importance

Metabolic and bariatric surgery (MBS) is an effective and safe treatment for obesity and its comorbidities, but less than 50% of those who are eligible and referred for MBS complete the procedure. The patient-physician relationship could be a decisive factor in the decision to complete MBS; however, this relationship has not been explored, particularly among racially and ethnically diverse populations.

Objective

To examine the association between patient-reported satisfaction with their patient-physician relationship and MBS completion by self-reported racial and ethnic group.

Design, Setting, and Participants

This prospective cohort study included 408 patients who were referred to a bariatric surgeon or obesity medicine program between July 24, 2019, and May 19, 2022.

Exposure

Patient satisfaction with their physician was measured by 7 dimensions (general satisfaction, technical quality, interpersonal manner, communication, financial aspects, time spent with physician, and accessibility and convenience) using the Patient Satisfaction Questionnaire Short Form.

Main Outcomes and Measures

Completion status for MBS (yes or no).

Results

A total of 408 patients (mean [SD] age, 47.3 [11.6] years; among 366 with data available, 317 [86.6%] women and 49 [13.4%] men) were included in the study. Of 363 patients with data available on race and ethnicity, 66 were Hispanic/Latinx (18.2%), 136 (37.5%) were non-Hispanic Black, 146 (40.2%) were non-Hispanic White, and 15 (4.1%) were other race or ethnicity. A total of 124 patients (30.4%) completed MBS. Overall, the mean (SD) patient satisfaction score was significantly greater in MBS completers vs noncompleters (3.86 [0.56] vs 3.61 [0.64]; P < .001). Multivariable logistic regression analysis showed technical quality was the most significant factor for MBS completion (adjusted odds ratio [aOR], 1.99 [95% CI, 1.24-3.19]), followed by communication (aOR, 1.78 [95% CI, 1.16-2.72]) and accessibility and convenience (aOR, 1.61 [95% CI, 1.03-2.53]). The interaction between racial and ethnic groups and patient satisfaction was not significant (eg, mean [SD] score for Hispanic/Latinx completers, 3.95 [0.55] vs 3.77 [0.60] for non-Hispanic White completers; P = .46 for interaction).

Conclusions and Relevance

These findings suggest that there is an association between patient satisfaction with the patient-physician relationship and the decision to complete MBS regardless of race and ethnicity. These findings have important implications for strategies to improve the proportion of qualified patients who complete MBS to achieve improved health outcomes.
Occult Breast Cancer With Anti-Ri Antibody Positivity and Pontine Hot Cross Bun Sign
Authors: Liu Yinglu , Huang Dehui , Wu Lei
Published: December 2022

This case report describes a 40-year-old woman with occult breast cancer with anti-Ri antibody positivity and pontine hot cross bun sign.
Early Specialization in Medical Education—A Pathway to Mitigate the Growing Physician Deficit
Authors: Kistemaker Rachel , Montez Kimberly
Published: December 2022

This Viewpoint discusses proposed pathways of modifying the medical education timeline that would aid in producing US physicians in a timelier manner.
Barriers to access cancer‐related services for men in high‐income countries: A narrative review looking beyond socioeconomic disadvantages
Authors: Zafar Ali , Baessler Franziska , Ihrig Andreas , Mayer Gwendolyn , Bugaj Till Johannes , Maatouk Imad , Staeudle Jens , Friederich Hans‐Christoph , Schultz Jobst‐Hendrik
Published: December 2022

Introduction

Cancer screening programs are routinely available in high‐income countries, but participation rates are low, especially among men. This narrative review aims to identify male‐specific access barriers to cancer‐related healthcare in high‐income countries that offer statutory insurance/subsidized health care.

Methods

We searched PubMed, Science Direct, and Web of Science for peer‐reviewed journal articles published within the past 10 years on cancer healthcare access, help‐seeking behavior, and men. Step‐wise screening of title, abstract, and full text resulted in 23 studies that fit the selection criteria for findings in high‐income countries. The results were analyzed descriptively using qualitative thematic synthesis.

Results

In the reviewed studies, barriers for men in accessing cancer‐related healthcare offers could be broadly categorized under sociocultural norms, personal behaviors, and structural problems. The most common barriers were related to sociocultural influences and included notions of masculinity, distrust in the medical system, and personnel/social commitments. Major personal barriers included fear of getting cancer or screening methods, lack of awareness about cancer, and problems in communication with healthcare professionals. Accessibility and lack of insurance were reported as common structural barriers.

Conclusions

The reluctance of men in approaching medical help was rooted in sociocultural norms of traditional masculinity with direct and indirect consequences such as fear, lack of awareness, distrust of medical personnel, and problems in communicating with healthcare professionals. Gender‐specific, male‐oriented information via digital, anonymous interventions may be helpful for increasing participation of men in cancer care.