bluuebunny/crossref_metadata_2025 huggingface dataset:
MORPHOFUNCTIONAL FEATURES OF THE MUCOUS MEMBRANE OF THE OESOPHAGUS IN THE CASES OF BRONCHIAL ASTHMAOF VARYING SEVERITY
Authors: Golovanova V E , Mikhaleva L M , Barkhina T G , Schegoleva N N , Ivanova E V
Published: October 2016

Studying morphofunional conditions of a mucous membrane of oesophagus of patients with a bronchial asthma of different severity became the research objective. We confirmed the combination of a bronchial asthma with eosinophilicesophagitis and nonspecific chronic esophagitis, aggravated in process of asthma progressing. In the work the necessity of differentiated tactics and conducting of the patients with bronchial asthma in the cases of accompanying pathology of oesophagus is scientifically grounded. We notice a problem of insufficient diagnostics and ineffective treatment of eosinophilic esophagitis in the cases of bronchial asthma.
CONSTRUCTION INFORMATION SYSTEM OF MENTAL Architectonics
Authors: Sudakov K V
Published: October 2016

In the present study attempts to provide the logic of the construction of cerebral architectonics of the systemic organization of mental activity that combines physical and physiological information (ideal) processes in their close cooperation. Information processes in the brain, as a wave and discrete atomic processes, probably closely related to a discrete organization, which is close to quantum physics, but in living organisms, they certainly have the qualitative features.
CONVENTIONAL RESPIRATORY REFLEX TO INCREASED RESPIRATORY RESISTANCE AS AN EXPERIMENTAL MODEL OF ADAPTIVE ACTIVITY
Authors: Byalovskiy Y Y
Published: October 2016

State Budget Educational Institution of Higher Professional Education “Ryazan State Medical University named after academician I.P. Pavlov” of the Ministry of Public Health and Social Development of the Russian Federation, Ryazan In the article it’s verified that conventional respiratory reflex to resistive load is the organism’s multicomponent reaction which can be used adequately as a model of adaptive human activity due to some methodical advantages: rapid reflex formation, relative strength, distinct quantitative evaluation criteria of components, relative simplicity of fulfillment of the methods. A step-like change in reinforcement of congenital respiratory reflex essentially rebuilts spatiotemporal structure of adaptive activity as well as its physiological cost.
THE RELATIONSHIP OF THE DIFFERENT TACTICS TO ACHIEVE THE RESULT OF THE SENSO-MOTOR ACTIVITY WITH THE SPECTRAL CHARACTERISTICS AND COHERENT OF THE BACKGROUND EEG OF THE SUBJECTS
Authors: Murtazina E P
Published: October 2016

Correlation analysis showed that the level of spectral power of the theta rhythm in the frontal and parietal cortex of the left hemisphere was inversely proportional to success, stability, sustainability of an inconsistent after errors and positively correlated, as well as capacity alpha-1 rhythm of the parietal and visual areas of the cortex of the right hemisphere of the brain, to the effectiveness of the points and risky nature of the subjects. Power beta 1 rhythm EEG central, parietal and occipital areas of the brain cortex are interconnected with the success of the subjects with both tactics of implementation the visual-motor test. Found asymmetry and different structural representation of the linkages tactics performance and characteristics of the background EEG test subjects.
Fractal-fluctuation analysis of heart rate nonlinear components to parameterize the functional condition
Authors: Lapkin M M , Vikhrov S P , Alpatov A V , Mitrofanova M Y
Published: October 2016

The article explains the use of the local fractal analysis of heart rate fluctuation that extends the standard fluctuation analysis DFA method and allows the assessment of real-time functional state of man as a quasi-stationary conditions and in conditions of transition.
ALGORITHM OF REHABILITATION AND REGENERATIVE TREATMENT IN DEPARTMENTS AND SPECIALIZED CENTER OF DEPARTMENTAL HOSPITAL
Authors: Laktionova L V , Konovalov O E , Mitkovskiy V G , Komarov N V
Published: October 2016

The article analyses the stages and tasks of rehabilitation and regenerative treatment of patients at the hospital stage in specialized center established on the basis of departmental hospitals. The scheme of the organization of medical-rehabilitation procedures is given.
RISK FACTORS AND PECULIARITIES OF CEREBRAL VESSELS ALTERATION IN PATIENTS WITH TYPE 2 DIABETES IN ASSOCIATION WITH CEREBROVASCULAR DISEASE
Authors: Dubinina I I , Jadnov V A , Yankina S V , Solovieva A V , Grishunina E A
Published: October 2016

In order to identify risk factors and to study alteration of cerebral vessels in patients with type 2 diabetes mellitus and cerebrovascular disease, ultrasound Doppler investigation of extracranial vessels was performed in 67 patients with type 2 diabetes mellitus. Atherosclerotic lesions of the vessels were detected in 67% of patients, depending on age, gender, body mass index, duration of diabetes and hypertension, systolic blood pressure, cholesterol and blood glucose level fluctuations during the day. The number of vessels affected by atherosclerosis and a higher degree of carotid stenosis was significantly higher in patients undergoing brainstroke. Quality of life was significantly lower in patients with diabetes associated with cerebrovascular disease, especially in patients after brainstroke.
MENTAL DISORDERS: MEDICO-LEGAL ASPECTS
Authors: Boyko I B
Published: October 2016

The author, based on modern concepts of mental disorder in law and medicine, has its own definition of the manifestations of "illness" that satisfies the scientific, educational and practical purposes.
MODERN ASPECTS OF ETIOLOGY AND PATHOGENESIS OF CANDIDOSIS OF ORAL MUCOSA (REVIEW OF LITERATURE DATA)
Authors: Mezhevikina G S , Darmogray Vasiliy Nikolaevich , Morozova S I , Savelyeva N A
Published: October 2016

The article is devoted to the review of the modern literary data regarding etiology and pathogenesis of candidiasis of oral mucosa. Changes of immune system in oral candidiasis are described separately.
SOCIAL HYGIENE AND HEALTH CHARACTERISTICS OF ELDERLY WOMEN LIVING IN RURAL AREAS
Authors: Uspenskaya I V , Pristupa E M
Published: October 2016

The paper presents the results of medical and sociological study of older women, conducted in one of the municipal districts of Ryazan region. In this study, the authors generated an average socio-hygienic portrait of a woman living in rural areas.
PATOGMONICHNYE SYMPTOMS OF CARDIAC ARRHYTHMIAS IN THE AGE STAGES OF CHILD DEVELOPMENT
Authors: Ascheulova T V , Grebova L P
Published: October 2016

We studed symptoms arytmies in different age of children. The children had jame peculiarity evolution in any age, structure hard and other organs and systems (displasies and inborn measurements). This symptoms helped to diagnostic arythmies timely.
OPERATION NEUROTIZATION FOR IRREPERABLE NERVE DEFECTS OF UPPER EXTRIMITIES
Authors: Khodjamurodov G M
Published: October 2016

In the article the problem of irreperable nerve defects is being considered as well as the possibilities to solve this problem through the operations of neurotization. In total 10 operations of neurotization were performed which is simple on technical performance and to achieve the same results identical to the direct reconstruction of nerves. Achieved results is stimulating for more wides application in cases when the direct reconstruction is more complicated and time and work consuming.
A CONDITION OF CONNECTIVE TISSUE AND A BLOOD FLOW IN THE SPERMATIC CORD IN MEN WITH INGUINAL HERNIAS, AS FACTORS OF SURGICAL TACTICS OF TREATMENT
Authors: Fedoseev A V , Muravyev S Y , Uspenskiy I I , Faleev V V
Published: October 2016

The paper studies the influence of severity of undifferentiated connective tissue dysplasia and changes in blood flow through the vessels of the spermatic cord in 36 men with inguinal hernias who underwent open Preperitoneal hernioplasty with “PROLENE” mesh. The average term of life with hernia was 21,5 months. Symptoms of connective tissue dysplasia revealed in 35 (97,2%) patients. The average speed of blood flow decreases from 11,9 cm/s in patients with mild UCTD to 9 cm/s - with a severe and shortage of blood flow increased from 12,5% to 25%. The difference between average speed of blood flow on the affected and healthy side, which before surgery was 2,78 cm/s, decreased to 1,0 cm/s, i.e. almost three times. Deficiency of blood flow before the herniotomy was 19,62%, after surgical treatment - 5,45%. Tension methods of hernioplasty cause a persistent decrease in average speed of blood flow on the affected side, even after several years.
MORPHOLOGICAL STUDY OF STRUCTURE PULP USAGE THE INTEGRATED PRODUCT
Authors: Chen Wei , Morozova S I , Kazantseva G P , El Uazzani Mohammed , Bezmen S A , Babuchkina E S
Published: October 2016

In an experimental evaluation of the effectiveness of an integrated preparation based on royal jelly and phytoecdysteroids in the treatment of deep caries.
CHARACTERISTICS AND TRENDS OF PRIMARY DRUG RESISTANCE OF MYCOBACTERIUM TUBERCULOSIS IN RYAZAN REGION
Authors: Panin I V , Dobin V L , Oskin D N
Published: October 2016

The article is devoted to drug-resistant tuberculosis in the Ryazan region. There is a tendency to the increase of the amount of tubercular patients among women of middle ages. It is stated that in the period from 1999 to 2007 mycobacteria’s structure of drug-resistance has not changed considerably. The exception was a dramatic increase of cases with simultaneous drug-resistance to the four first-line antibiotics. The direct interdependence between the character of drug-resistance and the speed and intensity of tuberculosis microorganisms growth has not been found yet.
ISOLATION, PHYSICOCHEMICAL RESEARCH AND DETERMINATION OF SOLUBILIZATING ACTIVITY TANACETUM VULGARE FLOWERS POLYSACCHARIDES
Authors: Kirichenko E E , Sytchev Y A , Chekulaeva G Y
Published: October 2016

From Tanacetum vulgare flowers was isolated polysaccharide; some of its physicochemical properties and solubilizating activity were studied, and also was suggested a new standardization method of this plant’s raw product.
MODERN TECHNOLOGIES OF TREATMENT OF CANDIDIASIS OF ORAL MUCOSA
Authors: Mezhevikina G S , Morozova S I , Savelyeva N A , Bezmen S A
Published: October 2016

The article is devoted to the review of the modern literary data regarding modern medicines used for treatment of candidiasis of oral mucosa. Classification, summary, harmful effects of modern medicines are described separately.
OPTICAL COHERENT THE TOMOGRAPHY IN DIAGNOSTICS AMBLYOPIA AT CHILDREN
Authors: Sokolov V A , Al-Sharufi A Khasan
Published: October 2016

One of the most often of the reasons of incomplete visual acuity is its functional decrease - amblyopia. It is observed amblyopia at ametropia high degrees, at astigmatism, it is especial at anizometropia, more often at a squint, at cataracts, congenital cataracts, optical nistagm, and also at patients with functional frustration of the central nervous system. Optical coherent tomography (OCT) has allowed to see objective changes of the central departments of a retina at amblyopia. However the data on these of change are inconsistent. The review is devoted to role OCT in diagnostics amblyopia.
FINASTERIDE INFLUENCE ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
Authors: Yakusheva E N , Chernykh I V
Published: October 2016

In the research on rabbits influence of finasteride on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of it’s marker substrate fexofenadine. It was found that the 14-days course of finasteride administration leads to tissue-specific induction of Pgp functional activity in liver and kidney.
DYNAMICS OF TRAFFIC INTENSITY OF MOTOR VEHICLES AND AIR POLLUTION BY THEIR EMISSIONS
Authors: Lyapkalo A A , Dementiev A A , Tsugran A M
Published: October 2016

There are results of sampling study of longstanding dynamics of traffic intensity of motor vehicles, transport conditions and emissions of the main pollutants into the atmospheric air. It is detected that in 1991-2009 on the road traffic routes of the city there was a significant increase in the traffic intensity and deterioration of transport conditions that resulted in a significant increase in air pollution by the emissions of the motor vehicles.
CAUSE-EFFECT RELATIONS OF THE ROAD TRAFFIC TRAUMATISM OF CHILDREN
Authors: Dedov A A , Chizhik-Poleiko A N , Tsomaya V V
Published: October 2016

The article is devoted to the uncovering and analysis of the cause-effect relations determining common factors of the origin, prevention, prophylaxis of the road traffic accidents with the participation of children of the preschool age and the primary school age.
MEDICAL AND SOCIAL RISK FACTORS FEW CHILDREN URBAN HOUSEHOLDS (FOR EXAMPLE, THE CITY OF RYAZAN)
Authors: Medvedeva O V , Panfilova T N
Published: October 2016

The analysis of medical and social risk factors of urban households having few children. Identifying the reasons why families refuse from birth, will determine the reserve births, to develop proposals aimed at optimizing the management of reproductive health and measures to encourage childbirth in region.
EFFECT OF ACUPUNCTURE ON MOTILITY OF THE LARGE INTESTINE IN PATIENTS WITH IRRITABLE BOWEL SYNDROME
Authors: Kusnetsov P S , Butov M A , Rychagova V O
Published: October 2016

As shown by the data of computed electrogastroenterocolography, acupuncture can successfully be used to arrest symptoms associated with disorders in the motor function of the large intestine, in particular, to eliminate pain, constipation and diarrhea in patients with irritable bowel syndrome.
ON TIMELY DETECTION OF ACUTE PYELONEPHRITIS PATIENTS WITH DIABETES
Authors: Anisimova N E , Aristarkhov V G
Published: October 2016

The paper analyzes data for early detection of acute pyelonephritis in patients with diabetes. The study was conducted from 2006 to 2011 GG The study group included 149 patients with UCP. During the analyzed period (2007-2011 years) was an increase in frequency of the isolation of microbial inoculation microflora from 47.8 to 53.4%. Predominant pathogen infections of the upper urinary tract in patients with diabetes was E.coli - 80-85%, enterococci isolated in 5-6,6%, Pseudomonas, (primarily P. Aeroginosa) at 1.7-3% Streptococcus - 0,7-2,2%.
MOLECULAR AND BIOLOGICAL MARKERS IN THE DIAGNOSIS AND PROGNOSIS OF THE GASTRIC MUCOSA INTESTINAL METAPLASIA
Authors: Vernygorodskyi S V
Published: October 2016

The expression of molecular and biological markers in the intestinal metaplasia (IM) of the gastric mucosa on the basis of pathomorphological analysis was studied. It is shown that the follow useful prognostic and diagnostic value have been used: differentiation of intestinal transcription factor (CDX2), cytokeratin 7 (CK7), mucin (MUC 5 AC) and a marker of proliferative activity -Ki-67. The algorithm for pathomorphological diagnosis of gastric mucosa IM with using of immunohistochemical markers was suggested.
DISCLOSURE, ANALYSIS AND IDENTIFICATION OF ECDYSTEROIDS IN MYOSOTON AQUATICUM AND CUCUBALUS JAPONICUS
Authors: Darmogray S V , Fursa N S , Erofeeva N S
Published: October 2016

By means of TLS of Myosoton aquaticum (L.) Moench. and Cucubalus japonicus L. herb ethanolic extracts a diverse assortment of ecdysteroids was revealed and their dominant components were identified with ecdysterones and polypodin B by the comparison with certainly known standards and HPLC-MS.
NOSOCOMIAL INFECTIONS AMONG MEDICAL PROFESSIONALS OF THERAPEAUTIC-AND-PROPHYLACTIC ORGANIZATIONS
Authors: Danilova E S
Published: October 2016

Presents a review of the national and foreign data of the literature devoted to questions of studying of a role of the biological factor in formation of occupational and occupationally related morbidity among medical professionals of therapeutic-and-prophylactic organizations. Statistical data of a nosocomial infection of the medical personnel is analysed, conclusions are drawn on leading risk factors and the cores preventive measures.
MEDICO-SOCIAL PROBLEMS OF INCIDENCE OF INFECTIONS SEXUALLY TRANSMITTED IN MODERN CONDITIONS (THE LITERATURE REVIEW)
Authors: Zhiltsova E E , Volkova S B
Published: October 2016

Infections sexually transmitted and their complications lead to considerable social and economic expenses entering into ten the most frequent reasons of the request for medical care and making the essential item of expenditure both national budgets of health care and family expenses. Social expenses also include the conflicts between sexual partners and violence in their family.
DILATED CARDIOMYOPATHY: A MODERN VIEW OF DISEASE
Authors: Zotova L A
Published: October 2016

Dilated cardiomyopathy - the primary lesion of the myocardium due to various reasons, characterized by a pronounced expansion of the heart chambers and decreased systolic and diastolic functions. Among the etiological causes in the first place should include a genetic predisposition. Diagnosis of the disease involves the identification of specific changes in echocardiography and the exclusion of other causes of heart failure. Therapy is symptomatic. Questions such as prediction of disease, improved survival, pathogenetic therapy, still await solution.
MORPHOFUNCTIONAL CHANGES OF PITUITARY-NEUROHYPOPHYSIS SYSTEM IN IMMATURE RATS WITH STREPTOZOTOCIN DIABETES MELLITUS
Authors: Zhurakivska O Ya
Published: October 2016

The research is devoted to the study of morphofunctional organization of the pituitary-neurohypophysis system of diabetes type 1. It was found that on the 14 th day after the streptozotocin diabetes simulation in 1-month old animals with hyperglycemia the increasing of functional activity of neurosecretory cells of supraoptic nuclei and increasing of bulk density in their neurosecretory granules are observed. Because of such conditions in the nervous lobe of neurohypophysis increase of bulk density of neurosecretory granules by the diffusing and the residual types are observed. On the 42 th day of the experiment constant high hyperglycemia leads to the stage of depletion of neurosecretory cells of supraoptic and paraventricular nuclei and development of dystrophic-destructive changes in them. In the neurohypophysis the reducing of bulk density of young and mature neurosecretory granules is observed. In the pituicytes of type-2 a large number of different sizes and shapes of lipid drops are observed.
BIOCHEMICAL MARKERS OF UNDIFFERENTIATED DYSPLASIA OF CONNECTIVE TISSUE IN PATIENTS WITH IDIOPATHIC MITRAL VALVE PROLAPSE
Authors: Osipenko I P
Published: October 2016

The complex clinical and instrumental examination of 120 patients with idiopathic mitral valve prolapse was conducted. The group of comparison consisted of 30 patients with undifferentiated connective tissue dysplasia without mitral valve prolapse. There were analysed changes in the levels of magnesium, adrenal cortex hormones (aldosteron, cortisol), amino acid composition in blood serum, identified patterns between these changes and clinical displays, degree of mitral valve prolapse, the frequency of detection the heavy arrhythmias, and selected groups of risk among patients.
FUNCTIONAL STATE OF ENDOTHELIUM IN DIFFERENT CLASSES OF CHRONIC VENOUS INSUFFICIENCY
Authors: Kachinskiy A E , Nikiforova L V
Published: October 2016

The study was completed according to ICH GCP criteria and included 127 patients with varicose disease admitted to Ryazan Regional Clinical Cardiological Dispensary in order to undergo surgical treatment. The patients were divided into three groups: the first (control) group included 14 healthy volunteers with no signs of varicose veins of lower extremities, the second group included 112 patients with varicose disease divided into three subgroups according to the CEAP classification clinical class of chronic venous insufficiency (CVI): 1 st - C2, 2 nd - C3-C4, 3 rd - C5-C6. All patients underwent a comprehensive analysis of functional state of endothelium (FSE) according to the level of its main metabolites: nitric oxide II (NO), endothelin 1-21, adhesion molecules sICAM- 1, sICAM-2, sICAM-3, and their topographic distribution. The level of endothelial dysfunction markers was studied in 15 patients with unilateral varicose disease in both healthy and affected extremity, which allowed for including them into the third group of patients. The results of the study suggest that the manifestation of endothelial dysfunction has the direct relationship with clinical classes of CVI. NO metabolites, endothelin 1-21, sICAM-1 had the highest sensitivity. The higher the CVI class, the higher the hypofunction of endothelium of varicose veins.
THE INFLUENCE OF EXPERIMENTAL SUBACUTE HYPOBARIC HYPOXIA ON P-GLYCOPROTEIN FUNCTIONAL ACTIVITY
Authors: Yakusheva E N , Chernykh I V
Published: October 2016

In a study on rabbits the effect of the experimental subacute hypobaric hypoxic hypoxia on the functional activity of ATP-dependent protein transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic of it’s marker substrate fexofenadine. It was found that 4-hour hypoxic action leads to Pgp induction.
INFLUENCE OF AMELANCHIER MEDIC POLYSACCHARIDE ON RESISTANCE OF BLOOD CELLS MEMBRANE
Authors: Laksaeva E A , Sichev I A
Published: October 2016

When adding to the blood a healthy donor water soluble polysaccharide complex of Amelanchier Medic fruit increases thermal, osmotic and peroxide resistance of erythrocyte membranes protecting cells from destruction caused by the action of experimental unfavorable factors
EXPERIENCE OF VALSARTAN USE IN GENERAL PRACTICE FOR THE TREATMENT OF COGNITIVE IMPAIRMENT IN PATIENT WITH ARTERIAL HYPERTENSION AND PAROXYSMAL ATRIAL FIBRILLATION
Authors: Krukov N N , Portnova E V
Published: October 2016

The case of successful influence optimum antihypertensive therapy on cognitive impairment is presented at the patient of 60 years with an arterial hypertension and paroxysmal atrial fibrillation.
THE COMPARATIVE CHARACTERISTIC OF NEUROPSYCHOPHYSIOLOGICAL STATUS OF PATIENTS WITH MULTIPLE SCLEROSIS AND PARKINSON’S DISEASE
Authors: Lorina L V , Butova V M , Dzhaparalieva N T
Published: October 2016

The role of а-motor neurons in the pathogenesis of spasticity and rigidity in multiple sclerosis and Parkinson’s disease. Extent of change in motor unit potentials (MUP) in multiple sclerosis and Parkinson’s disease is directly dependent on the shape and duration of the disease. Quality of life, health-related, in patients with multiple sclerosis suffer less than in patients with Parkinson’s disease. All patients perceive their disease as a stressful factor reduces the quality of life and limits their role in society.
MYC FAMILY GENES IN SOLID-PSEUDOPAPILLARY TUMORS OF THE PANCREAS
Authors: Gordienko E N , Pakhlina O V , Chekmareva I A , Rothin D L , Gorin D S
Published: October 2016

In the paper the study of molecular disorder genes c-Myc and N-Myc in solid-pseudopapillary tumor of the pancreas. Examined 24 samples of tumors obtained from 21 patients, including 19 primary, recurrent 1, 4 metastasis. Fluorescence in situ hybridization was performed using DNA samples lokusspetsificheskih to the loci 2p24, 6q23, 8q24 company «Vysis, Abbott Laboratories Inc», demonstrated that amplification of the N-Myc gene in solid-pseudopapillary tumor can be another confirming its neurogenic origin.
THE CHITOSAN-COATED IMPLANTS WITH BIOACTIVE SURFACE DEMONSTRATE IMPROVED CHARACTERISTICS OF OSSEOINTEGRATION IN RATS
Authors: Novochadov V V , Gaifullin N M , Zalewski D A , Semenov P S , Shemonaev V I
Published: October 2016

The application of chitosan on bioactive surface of the screw titanium implants was shown to improve the morphological characteristics of osseointegration after implantation into the rat femoral bone. The additional osteoconductive effect of the fine-dispersed chitosan appeared in more intensive and rapid osteogenesis around implants, and the more expressed remodeling and thickening of the surrounding trabecular bone.
CHANGES IN RAT THYMUS MORPHOLOGY AND FUNCTION AFTER CHRONIC EXPOSURE TO LOW DOSES OF DDT
Authors: Rodichenko E P , Yaglova N V , Yaglov V V , Obernikhin S S
Published: October 2016

There is increasing evidence that chronic environmental exposure to DDT and other pesticides play an important role in disregulation of the immune system and increased incidence of autoimmune and allergic diseases. The aim of the research was to investigate whether consumption of low doses of DDT may affect the immune system and change morphology and function of thymus. The research was performed on 42 Wistar rats 80-100gg body weight. Rats were exposed to 1.89±0.086μg/kg DDT per os for 6 and 10 weeks. Histological examination found time-depending acceleration of apoptosis both of lymphocytes and reticuloepitelial cells. After 10 weeks of exposure proliferation of thymocytes was significantly decreased. Concanavalin A-induced mitogenic activity of thymocytes after 10 weeks of exposure to DDT was 6 times higher than the control values. The data obtained showed that even low doses of DDT accelerated thymus aging and modulated proliferation of thymocytes.
SOME ASPECTS OF RHEUMATIC HEART DISEASE PROBLEM
Authors: Petrov V S
Published: October 2016

The fifth years condition of patient with rheumatic heart disease, change in quality of life, echocardiographic data and chronic heart failure progress present in article. The patients had not change in chronic heart failure condition and quality of life but had negative echocardiographic dynamic. Combination of atrial fibrillation, diabetes mellitus, severe mitral stenosis and left atrial dilatation increase risk of death patients with rheumatic heart disease.
METABOLIC SYNDROME IN THE PRACTICE OF THE THERAPIST CITY POLYCLINIC: EXPERIENCE OF DIETARY THERAPY JAM OF LAMINARIA, ENRICHED WITH CHROMIUM, AND METFORMIN
Authors: Dashkevich O V , Nizov A A , Lapkin M M , Trutneva E A , Gershunskaya V V
Published: October 2016

We investigated safety and efficacy of metformin and dietary product - jam laminaria, enriched with chromium, in integrated ambulatory treatment of patients with metabolic syndrome (MS). During the 6 months we observed 81 patients with MS, the average age of 50, 3 ± 1, 9 years old, who were divided into 3 comparable groups. Patients of the comparison group (n=30) with recommendations on modeling lifestyle and drug therapy of diseases; the first group of patients (n=31) was additionally appointed with metformin 1500-2000 mg/day, and patients in the second group (n=20) received dietary product 20 g/day. Surveillance in all groups of patients registered reduction of overweight, improved clinical and laboratory parameters, adaptive organism reserves and quality of life. The use of metformin and the dietary product in treatment of MS allowed to achieve a more pronounced positive dynamics in patients than in the comparison group.
HYPOTHYROIDISM AND PREGNANCY
Authors: Titova L Y , Aristarkhov V G , Puzin D A
Published: October 2016

The functional status of the thyroid gland (TG). Inpregnant women with a hypothyroidism. Using laser therapy treatment with thyroid contributes to lowering titer antibodies to TPO and the quality of TSH.
PUNCTURE DRAINING TREATMENT OF PANCREATIC CYSTS IN CASE OF CHRONIC PANCREATITIS
Authors: Tarasenko S V , Karyukhin I V , Rakhmaev T S , Lunkov I A , Nikitin D A , Donyukova S P , Panina N Y
Published: October 2016

The paper analyzes the results of percutaneous puncture draining treatment for pancreatic cysts in 38 patients in case of chronic pancreatitis in 2008 to 2012. The first stage of treatment was carried out percutaneous thin needle aspiration puncture of the contents of the cavity cysts under ultrasound guidance. A different approach to diagnostics as well as to surgical management of complications is offered. The early and accurate diagnosis of pancreatic cysts, in which ultrasound study plays a major role, is a condition for their successful treatment. Indications to different surgical methods are formulated differently depending on complications of cysts, localization, sizes, «maturity» of cyst walls, communication with main pancreatic duct. Puncture treatment was used in 7 patients; percutaneous drainage under ultrasound guidance was performed in 31 patients. No mortality rate was noted. Miniinvasive puncture-draining interventions were effective in 33 patients, which amounted to 86,9 %.
THE MORPHOLOGICAL FEATURES OF HUMAN HEPATOCYTES IN EARLY PERIODS OF ONTOGENESIS
Authors: Ponomarev B L , Obuhova L E , Vysoski U A , Barsukova N I , Cherdantseva T M
Published: October 2016

The developmental features of liver of human embryos and featuses during early ontogenesis are the subject of electron microscopy study. The changes in hepatocytes ratio of different differentiation stages during late periods of embryogenesis and early periods of fetogenesis are identified. The formation of cytoplasmic organelles and changes of nucleo-cytoplasmic ratio of liver were are observed.
Cell and cell-MATRIX INTERACTIONS IN TUMORS: CURRENT STATE OF THE PROBLEM
Authors: Mnikhovich M V
Published: October 2016

In an article in the form of a literature review highlights current understanding of cell-cell and cell-matrix interactions in tumors.
NATURAL SCIENCE CATEGORY OF SYMMETRY-ASYMMETRY IN BIOLOGY OF ADAPTATION: INVESTIGATION OF HUMAN ADAPTATION TO THE MAGNETIC WAVE FACTORE
Authors: Ukhov U I , Krapivnikova O V , Kositsin N S
Published: October 2016

Using of symmetry-asymmetry category as identification in effects of the different factors to adaptation abilities of a whole organism at the model of stress-reaction to magnetic stimulation is discussed in the article. Sympathetic effects of regulation are researched by cardiointervalomethric method, using stress-index as the criteria of stress-level. It is shown that both low and high level of asymmetry in neural centers activities decreases effects of magnetic stimulation, dynamic in stress-index is dependent on asymmetry level too.
COMPARATIVE HYGIENIC ANALYSIS OF AIR QUALITY IN RYAZAN DISTRICTS
Authors: Lyapkalo A A , Dementiev A A , Tsurgan A M
Published: October 2016

In the article there are results of the comparative analysis of air quality in Ryazan districts according to the data of the analytical control over the content of nitrogen oxide and nitrogen dioxide, sulphur dioxide, carbon oxide, sum of hydrocarbons, plumbum and its inorganic compounds, formaldehyde and suspended substances. Ranking of the city districts was done in the dependence on air quality. It was revealed that the districts “Gorodskaya Roszha” and “City Centre” occupy the first and the second places correspondently by the size of specific emission, equivalent emissions regarding reflex and resorptive effect and indices of emission hazard rating of interdistrict motor transport.
Value assessment in outflow tract reconstruction femoral-tibial
Authors: Pokrovsky A V , Yahontov D I
Published: October 2016

The paper presents an algorithm for estimating the initial state outflow tract and assessment of their impact on the immediate and long-term results of treatment of patients with obliterating diseases of the femoral- popliteal - tibial segment. The study included 92 patients who had undergone multiple reconstructive operations in the segment below the knee and, 15.2 % of the patients initially had good outflow tract , in 39.1 % of patients determined satisfactory condition outflow tract and in 45.7 % of cases initially identified poor outflow tract.
Immunohistochemical characteristics age transformation of the cell phone mastoid brain people of different sex
Authors: Pavlov A V , Saveljev S V
Published: October 2016

Age-related changes in the structure of the human brain mamillary bodies were found in different age and sex. In elderly and senile age there is a decrease of GFAP-immunopositive cells. This process leads to an involutive transformations of neurons in the appropriate age. From 45 years of age in the mamillary bodies NSE-immunopositive cells are located around blood vessels in both sexes. Such an arrangement may be due to age-related changes in hemodynamics this structure. Reducing the number of MBP-immunopositive fibers in the elderly explains violation of synaptic connections both within the mamillary bodies and beyond. The observed changes in the expression of selected neuronal markers indicate age involution of mamillary bodies in both sexes.
Research flow cytometric of the DNA content in tumor cells of lung cancer patients with paraneoplastic rheumatic syndrome
Authors: Lysenko S A , Kirkilevsky S I , Chereshnyuk I L
Published: October 2016

The study of the DNA content and cell cycle indicators of tumor cells of 70 lung cancer patients: 30 patients with paraneoplastic rheumatic syndrome (PNRS) and 40 - without manifestations of the syndrome. Found that in tumors of lung cancer patients with PNRS, unlike tumors of lung cancer patients without symptoms of this syndrome are observed higher proliferative activity of tumor cells (S-phase), increased indicators of DNA aneuploidy (DNA index, cell index, aneuploidy index) and also have lower levels of apoptosis. All these changes are indicative of more highly aggressiveness and malignancy of tumor process in lung cancer patients with PNRS.
Matrix metalloproteinase-9 as a biomarker of poag
Authors: Sokolov V A , Levanova O N , Nikiforov A A
Published: October 2016

Diagnosis of primary open angle glaucoma (POAG) early stages of the pathological process remains a difficult task, even for experienced ophthalmologists. This work is devoted to the study of matrix metalloproteinase-9 (MMP-9) in lacrimal fluid of patients with POAG as a biomarker of this disease. Revealed a significantly higher concentration of MMP-9 in a lacrimal fluid in patients with glaucoma, at the initial stage of the pathological process. Dependence between levels of MMP-9 and stages of the pathological process has been established.
Kinds of rhinolordosis at the combined deformations of a nose and methods of their surgical correction
Authors: Medvedev V A
Published: October 2016

In the group consisted of 56 patients with rhinolordosis, combined with other deformities of the nose was the most often identified (total) bone and cartilage form of rhinolordosis - 31 cases (the sizes of implants were the largest and donor cartilage was commonly used). Cartilaginous form was less commonly observed - 22 observations (the sizes of implants were smaller and donor cartilage was used less frequently). The most rare form of rhinolordosis was bone kind - 3 cases (the sizes of implants were the smallest and only autocartilage of the nasal septum was used). The use of a donor cartilage at lack of an own material during operations concerning rhinolordosis is justified and expediently.
Regularities of gastrointestinal sphincter structure and functions
Authors: Lazutina G S , Rumyantseva T A
Published: October 2016

The article provides a brief literature review of the definitions "sphincters of digestive system.” The authors discuss various morphological data of gastrointestinal sphincters in connection of structure, function and organization of their innervation. The article presents data of different authors about terminology, classifications and innervation of the sphincter apparatus of the gastro-intestinal tract. Particular attention is paid to the role of their own pacemaker interstitial cells of Cajal (the organizers of peristalsis).
Morpholology of immune system of offspring after stimulation of maternal immune system in early pregnancy
Authors: Yaglova N V , Obernikhin S S
Published: October 2016

Stimulation of maternal immune system in early pregnancy with Concanavalin A, a T-cell mitogen, prior to formation of fetal immune system impairs development of the offspring’s spleen and thymus. Our findings demonstrate that short-term exposure of pregnant murine dams to Concanavalin A, leads to retardation of postnatal development of offspring’s spleen and reduction of lymphocytes count in thymus medulla and accelerated formation of thymic corpuscles.
Nicotinic acetylcholine receptors as modulators off sympathetic neurons and sattelit glial cells protein-synthesizing systems in cranial cervical ganglion
Authors: Gorelikov P L
Published: October 2016

In the experimentally established pharmacological blockade of nicotinic cholinergic receptor type (nCR) was studied the dynamics of the content of RNA in the cytoplasm of neurons and in the sattelite glial cells cranial cervical sympathetic ganglion of rabbits. It was determined the neurotrophic nCR role in the cellular mechanisms of the ganglion, which lies in the fact that the synaptic signal through nHR has modulating effect on the activity of the protein-synthesizing system in neurons and is coordinating this activity with the metabolic activity of neighboring satellite glial cells.
Oral hormonal contraceptive "janine" influence on P-glycoprotein functional activity
Authors: Yakusheva E N , Kotlyarova A A , Nikiforov A A
Published: October 2016

In the research on rabbits influence of combined oral contraceptive, "Janine" on the functional activity of the protein efflux transporter P-glycoprotein (Pgp) was studied. Pgp activity was assessed by pharmacokinetic analysis of marker substrate fexofenadine. It was found that administration of the drug "Janine" for 14 and 21 days, resulting in inhibition of Pgp functional activity.
Medical complications in hip joint arthroplasty in elderly patients
Authors: Fedoseev A V , Al Mansour Ah Y , Litvinov A A , Chekushin A A , Filonenko P S , Bondareva J A , Zaitseva E A
Published: October 2016

The article presents data on the number and nature of perioperative complications in 67 patients undergoing hip replacement. 18% of patients had gastro- and duodenopathy; venous system pathology in 21% and chronic DIC in 46%.
Execution efficiency videoassisted anatomic lung resections
Authors: Hiller D B , Sadovnikova S S , Papkov A V , Giller G V , Glotov A A
Published: October 2016

In the surgical department of the Central Research Institute of Tuberculosis 226 patients with advanced destructive pulmonary tuberculosis were performed 230 lobectomy resection volume and more. In the main group - (126 patients), 130 was performed using surgical interventions Videoassisted art, in the comparison group - (100 patients), 100 resections were performed by standard methods. When using Watsu art intraoperative blood loss was 2.8 times lower transfusion missing, narcotic analgesics were not used in 80% of cases of postoperative complications was 2.7 times less mortality was absent, and the effectiveness of treatment was higher.
Association of polymorphism of AGT (T174M), TNF-A (G308A) and MTHFR (A222V) with desadaptive remodeling of heart after a Q-myocardial infarction
Authors: Kuzmin A G
Published: October 2016

The results of the study of morphological and functional parameters of the heart, gene polymorphism AGT (T174M), TNF-Α (G308A) and MTHFR (A222V) in patients after Q-myocardial infarction with chronic heart failure, II, III functional class. In patients undergoing Q- myocardial infarction adverse clinical phenotype of chronic heart failure is associated with alleles and genotypes T/M, M/M gene AGT (T174M), and A allele genotypes A/G, A/A gene TNF-α (G-308A), C allele and genotype C/T gene MTHFR (A222V).
Anthropometric characteristics of students on J. Tanner’s classification
Authors: Lopatina L A , Serezhenko N P , Sokolov D A
Published: October 2016

The analysis of anthropometric and functional indices 292 male medical students of Voronezh city at the age of 17-21 years was carried out, depending on somatic sexual differentiation. The indexed evaluation of physical development has been received. Most of the boys had a gynaecomorphic or mesomorphic body type. Gynaecomorphism is characterized by a narrow rib cage, increasing of the transverse diameter of the large pelvis, brahiskelia and normoskelia. That is why among gynaecomorphic boys people with strong sexual constitution revealed more significantly. This makes it possible to consider gynaecomorphia in men a predictor of premature aging. Andromorphism is characterized by the ongoing process of acceleration: increasing the length of the body while standing and sitting and trochanter height. Evaluation of physical development of young men showed that the index of sexual dimorphism can be used as a marker in the evaluation of physical health.
Characteristics of morpholodgical changes of the vascular wall at restenosis
Authors: Staroverov I N , Korablev A V , Lonchakova O M
Published: October 2016

The research of morphological changes in a wall of the main arteries at the patients were operated about restenosis or reocclusion, after earlier executed reconstructive interventions on an aorto-femoral segment, have been conducted. It have been revealed that performance of an endarterectomy leads to rough damage of the vascular wall with formation of neointimus changes and cicatrization. Implantation to a vascular wall a foreign matter leads to develop the chronic productive inflammation, being accompanied the excess growth of textus connectivus. The revealed changes significantly differ from those at atherosclerotic defeat.
Vitamin D and calcium supply of the prepubertative children in south Bashkiria
Authors: Kamilov F Kh , Agletdinov E F , Golovatskikh I V , Kuznetsova E V , Bikmetova E R
Published: October 2016

The 180 school-children 8-9 years age-old from Meleuz and Meleuz district of Bashkortostan Republic (53 0 north breadth) in autumn (September) were investigated the content of 25-hydroxyvitamin D, parathyroid hormone, calcium, phosphorus, magnesium in the serum and the level of daily intake of calcium from food. As a result of data analysis was concluded that 72% of the urban and 29,6% of rural children have a deficiency of vitamin D, with 28% and 63% respectively D-subclinical vitamin deficiency. Parathyroid hormone content was higher in of urban children than in rural areas. Daily calcium intake was 60-70% age norms and does not significantly differ from place of residence. The amount of milk and dairy products consumed by children is significantly lower than the recommended norms and is 26-39%.
Urgent character of cancer prophylaxis in Ryazan region
Authors: Kuchumov V V , Lyapkalo A A , Medvedeva O V
Published: October 2016

There are data about cancer mortality and morbidity in the population of Ryazan region. Rating of administrative territories allowed to detect deprived territories. There is analysis of risk factors affecting the mortality, morbidity and rate of oncopathology in Ryazan region. It was detected that imbalance of feedstuff, overweight, age, low average income of the population help for prevalence of oncological diseases. Influence of the neglected oncological diseases on mortality and lethality within the first year upon diagnosis of the disease was detected.
Contribution arrangements zemstvo medicine in the development of prevention of socially significant diseases
Authors: Lashkul Z V
Published: October 2016

During the health care reform in various literary sources have different opinions organization of medical care and its impact on key health indicators in different periods of the historical development of our state. A number of publications, go to the organization of primary health care on the basis of a family doctor, compared with the period of zemstvo medicine, while comparing both positive and critical. The aim of healthcare reform in different historical periods of mankind, it is primarily the adoption of such a model, the organization of medical care that would improve access to health care and a positive effect on key health indicators and demographic situation.
Features of examination of patients with coronary heart disease in outpatient practice according to observation in a registry study
Authors: Pereverzeva K G , Vorobev A N , Nikulina N N , Moseichuk K A , Pravkina E A , Yakushin S S
Published: October 2016

Basing on the analysis of a registry study, of the usage of diagnostic methods in patients with coronary heart disease in the outPatient setting, and their comPliance with the guidelines of the Russian Society of Cardiology were assessed. An outpatient registry included 3672 patients with hypertension, coronary heart disease, heart failure and atrial fibrillation who aPPealed to theraPist or cardiologist for medical aid. High incidence rate of CHD with hypertension (98.9 %) and CHF (91.3 %) was registered in the study. The registry revealed lack of active CHD patients follow-up by therapists and cardiologists, insufficient use of instrumental and laboratory diagnostic techniques for the confirmation of coronary artery disease.
IMPACT ASSESSMENT OF SURGICAL DAMAGE DURING PERFORMING INGUINAL HERNIOPLASTY TO THE FUNCTIONAL STATE OF THE TESTIS AND POTENTIAL OF THE FERTILITY
Authors: Sobennikov I S , Aristarkhov V G , Cherenkov A A , Kotans S YA , Motin A P
Published: October 2016

The paper studied the effect of surgical damage, applied during hernia repair, on morphology and function of male sex glands and fertility forecast for example 24 patients of reproductive age undergoing surgery for inguinal hernia. Depending on the method of hernia repair the dynamics of indicators of testicular blood flow by dopplerography, the average levels of sex hormones in blood plasma and spermiogram in the preoperative and postoperative period was studied. Based on the analysis of the data revealed a low-impact way of inguinal hernia repair, has minimal impact on the male reproductive function.
RISK AS SYSTEM ORGANIZATION INDEPENDENT COMPONENT OF AN INDIVIDUAL PURPOSEFUL ACTIVITY
Authors: Vlasenko R Ya , Loseva T N
Published: October 2016

In the article various theoretical approaches in studying risk behavior are discussed, and also the attempt to consider the phenomenon of risk according to the general theory of the functional systems of academician P. K. Anokhin is made. The theoretical statements proving the possible addictive nature of the activity associated with risk are given. It is supposed that the readiness for the risk represents a particular specific motivational condition which, under the terms of uncertainty, is integrated into a functional system. The risk is considered as the independent component of the system organization of an individual purposeful behavior.
THE ACTIVITY OF LYSOSOMAL ENZYMES IN UNCOMPLICATED POSTPARTUM AND ENDOMETRITIS
Authors: Chikin V G , Erokhina A A , Pchelintsev V V
Published: October 2016

The inflammatory process in any localization is accompanied by an increase of the enzymatic activity in the focus of inflammation and blood, which is an important patogenenetic element in the development and result of inflammation in the uterus in normal postopartum and postpartum complicated by endometritis. There was the research of activity of the lysosomal enzymes (cathepsin D, β-D-galactosidase, DNA-ase) for determining of their clinical significance in the diagnostics and controlling of their efficiency of treatment of postpartum endometritis. Identified changes in the concentration of these enzymes in metroaspirate are more informative to measure the severity of the inflammatory process in the uterus.
VENOUS BLOOD LYMPHOCYTE APOPTOSIS IN ELECTROMAGNETIC RADIATION TREATED PATIENTS WITH SEPSIS
Authors: Vladimirova E S , Borovkova N V , Gorbunov A M , Andreev Y V , Babayev O V
Published: October 2016

This article presents the experience of low-intensity electromagnetic radiation application in the complex treatment of patients with sepsis. As a carrier of electromagnetic radiation used a standard plastic card with a magnetic stripe HiCo, which were fixed on the skin projection iliac arteries. The article presents the results of treatment of 22 patients with severe sepsis criteria and multi-organ failure, whose complex treatment included, applied electromagnetic radiation. Electromagnetic radiation efficiency was studied with apoptotic lymphocyte count and concentration of dead leukocytes of venous blood, using method of flow cytometry. The study was performed before and 1 hour after the imposition of electromagnetic radiation carrier. The most pronounced effect of low-intensity electromagnetic radiation indicators noted in lymphocyte apoptosis venous blood, but these changes lymphocytes apoptotic had prominent controversial direction. Mechanisms of electromagnetic fields action on the carrier body and apoptosis remain unclear and require further study.