bluuebunny/crossref_metadata_2025 huggingface dataset:
CHARACTERISTICS OF HEPATIC STELLATE CELLS PHENOTYPES IN CHRONIC HEPATITIS C
Authors:   Grodno State Medical University, Grodno, Belarus, Kondratovich I. A. , Tsyrkunov V. M. ,   Grodno State Medical University, Grodno, Belarus, Andreev V. P. ,   Grodno State Medical University, Grodno, Belarus, Kravchuk R. I. ,   Grodno State Medical University, Grodno, Belarus
Published: September 2022

Background. Hepatic stellate cells (HSC) play a key role in the development of liver fibrosis in different damages. The aim is to present the structural-functional and quantitative characteristics of various HSC phenotypes in chronic hepatitis C (CHC). Material and methods. The object of the study was 18 liver biopsies of patients with verified CHC (HCV+ RNA in PCR). The stage of liver fibrosis was assessed by Metavir. Structural, functional and quantitative characteristics of different phenotypes of 160 analyzed HSCs at different stages of fibrosis in CHC were assessed by the results of light (semithin sections) and electron microscopy. We determined the average area, length and width of one PSL in each biopsy specimen, the number of lipid droplets in all and in one PSL as well as the average area, length and width of one lipid droplet. Results. At different stages of fibrosis in CHC, all three HSC phenotypes, which had differences in the main structural and quantitative parameters, were simultaneously detected in the patient. Predominantly (44.4%), HSCs corresponding to the non-activated (sleeping) phenotype were detected, less often (20.6%) – those corresponding to the active (myofibroblastic) phenotype. As the HSC was activated, the shape of the cells changed (star-shaped–elongated), the number of lipid droplets in the cell decreased without changing the size of the inclusions, and the cytoplasmic/nuclear ratio changed towards an increase in the nucleus. The frequency distribution of phenotypes depended on the stage of liver fibrosis. Conclusions. Patients with CHC are characterized by the presence of all three HSC phenotypes, which differ from each other in structural and quantitative characteristics, the frequency of which depends on the stage of liver fibrosis.
MEDICO-SOCIOLOGICAL AND SITUATIONAL FACTORS IN THE PSYCHO-EMOTIONAL STATE OF WOMEN WITH EARLY REPRODUCTIVE LOSS
Authors:   Grodno State Medical University, Grodno, Belarus, Kastsovа L. V.
Published: September 2022

Purpose of the study: To evaluate socio-psychological characteristics of women after early reproductive loss and to suggest some forms of psychological support for this category of patients. Material and methods. The sample is represented by 64 women of reproductive age with a primary episode of pregnancy loss. A medical and sociological interview and psychological questionnaire were conducted using the Spielberg-Khanin scale (State-Trait Anxiety Inventory, STAI). Results. The material of the pilot sample demonstrates the significance of the situationally conditioned psychoemotional state (ideas of self-blame and situationally conditioned anxiety) of women with early reproductive loss and shows the directions and forms of possible outpatient psychological intervention after experiencing perinatal loss (respiratory gymnastics, auto-training, neuromuscular relaxation, music and art therapy). Conclusions. In order to maintain mental well-being in women after early reproductive loss, a comprehensive integrative approach is needed, including the provision of medical care by an obstetrician-gynecologist and psychological support by a psychologist at an antenatal clinic.
THE LABORATORY OF CLINICAL BIOCHEMISTRY OF THE DEPARTMENT OF HOSPITAL THERAPY OF GRODNO STATE MEDICAL INSTITUTE: INTER-INSTITUTIONAL AND INTERDEPARTMENTAL EXPERIENCE OF FRUITFUL COOPERATION
Authors:   Grodno State Medical University, Grodno, Belarus, Moiseenok A. G.
Published: September 2022

The article considers the background for the establishment in the year 1968 and the activities of the joint laboratory of clinical biochemistry of Grodno State Medical Institute and Grodno Regional Clinical Hospital that formed a basis for multi-disciplinary clinical and biochemical studies for research projects and solving problems in practical health care. The laboratory served as a basis for preparation of more than 10 candidate and doctoral dissertations, which allowed to achieve a high level of biochemical research in hospital patients and to obtain new findings in the fields of coagulogy and vitaminology.
Representasi Pesan Mimpi Amerika (American Dream) Dalam Film Fatherhood
Authors: Siswandi Kinanti , Putra Asaas , Jati Agus Pramono , Haqqu Rizca
Published: September 2022

Stereotip mengenai ras kulit hitam sering dikaitkan dengan kemiskinan. Sekumpulan orang Amerika menganggap ras dan kemiskinan dengan berlebihan sehingga orang Afrika-Amerika lama dikenal sebagai orang yang miskin dan malas. Hingga kini isu mengenai kesetaraan yang selalu dibahas dalam american dream masih belum tercapai. Film Fatherhood yang disutradarai oleh Paul Weitz dan dibintangi oleh Kevin Hart adalah sebuah film yang merupakan representasi Mimpi Amerika (American Dream) mengenai kesetaraan atau tidak adanya rasisme, padahal pada kenyataannya masyarakat masih sering mengalami situasi yang berkaitan dengan rasisme terutama pada ras kulit hitam. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana pesan Mimpi Amerika tergambarkan dalam film Fatherhood. Penelitian ini merupakan penelitian kualitatif dengan paradigma kritis menggunakan metode interpretasi. Melalui analisis semiotika John Fiske yang terbagi menjadi 3 level yaitu: level realitas yang terdiri dari kode tampilan, kostum, ekspresi serta gerakan; level representasi yang terdiri dari kode kamera, setting dan juga kode dialog; level ideologi yaitu stereotip rasisme terhadap ras kulit hitam, penulis menemukan adanya upaya untuk mematahkan stereotip yang tertanam dalam benak masyarakat mengenai rasisme terhadap ras kulit hitam, terutama bagi sosok ayah ras kulit hitam. Hal tersebut menunjukkan adanya pesan representasi Mimpi Amerika dibalik film fatherhood.
Nonlinear parabolic problems with an unknown source function and their applications for modelling and control of filtration processes
Authors: Гольдман Н.Л.
Published: September 2022

Работа связана с изучением нелинейных параболических систем, возникающих при моделировании и управлении нестационарными процессами фильтрации в подземной гидродинамике. Одна из постановок является системой, которая включает в себя краевую задачу второго рода для квазилинейного параболического уравнения с неизвестной функцией источника в правой части, а также уравнение изменения по времени этой функции. В другой постановке рассматривается проблема управления этой системой с управляющим воздействием граничного режима. Данные постановки существенно отличаются от обычных краевых задач и задач управления для параболических уравнений, в которых предполагается, что все входные данные должны быть заданы. Полученные в работе результаты представляют не только теоретический интерес, они имеют практическое значение для исследования различных фильтрационных процессов. Приведены некоторые примеры таких приложений, связанных с движением жидкости в трещиновато-пористых средах.

The work is connected with study of nonlinear parabolic systems arising in the modelling and control of nonstationary filtration processes in underground hydrodynamics. One of such statements is formulated as a system that involves the boundary value problem of the second kind for a quasilinear parabolic equation with an unknown source function in the right-hand side and, moreover, involves an additional equation for a time dependence of this function. In the other statement we consider control of this system controlled by the boundary regime. These statements essentially differ from usual boundary value problems and control problems for parabolic equations, where all the input data must be given. The obtained results have not only the theoretical interest but they are also important for investigation of various filtration processes. Some examples of such applications connected with fluid flow in the fractured porous media are discussed.
Changing the Landscape of Hypertension Management With SGLT2i
Authors: Bilić Ćurčić Ines , Ninčević Vjera , Canecki Varžić Silvija , Prpić Križevac Ivana , Milas Ahić Jasminka , Mihaljević Ivica
Published: September 2022

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a newer class of drugs that have primarily been used in the treatment of type 2 diabetes. However, as new findings from clinical trials have become available, their indication has been expanded to include treatment of heart failure and chronic kidney disease without the presence of diabetes. The pathophysiological mechanisms of extraglycemic effects of SGLT2i are still being unraveled, but one of the most prominent consequences is a decrease in blood pressure, which has implications for hemodynamics and arterial stiffness. Recent findings indicate that this class of drugs has a beneficial effect on lowering nocturnal blood pressure (BP), with special importance in type 2 diabetes (DMT2), since unregulated nocturnal hypertension is associated with an increased incidence of cardiovascular (CV) events. In this mini-review, we have summarized current knowledge about the effects of SGLT2i on blood pressure, including office, home, and ambulatory BP, and potential implications for treatment of hypertension in diabetic and non-diabetic individuals, with positive effects on cardiorenal outcomes.
HUBUNGAN MOTIVASI PERAWAT DAN SUPERVISI KEPALA RUANGAN TERHADAP PENDOKUMENTASIAN DISCHARGE PLANNING DI RUMAH SAKIT TK. II KARTIKA HUSADA
Authors: Mikha Mikha
Published: September 2022

Latar Belakang: Discharge planning adalah proses dimana tim rumah sakit yang berhubungan dengan pasien mengatur pengembalian pasien ke rumah mereka atau pindah ke tempat perawatan lain. Adapun yang mempengaruhi pelaksanaan discharge planning yaitu motivasi perawat dan supervisi kepala ruangan.   Tujuan: Mengetahui hubungan antara motivasi perawat dan supervisi kepala ruangan dengan kinerja perawat dalam pendokumentasian discharge planning. Metode: Ada hubungan kuantitatif dengan menggunakan cross sectional Instrumen penelitian meliputi angket skala likert dan checklist untuk observasi. Analisis data univariat dan bivariat.Hasil: Dari hasil uji analitik, kinerja perawat dalam pencatatan discharge plan dipengaruhi oleh motivasi dan supervisi yang dilakukan oleh kepala ruangan. Kesimpulan: Terdapat korelasi antara motivasi perawat dan supervisi kepala ruangan terhadap pendokumentasian discharge planning, akan tetapi korelasinya berlawanan arah.
FAKTOR-FAKTOR YANG MEMENGARUHI KURANG MINATNYA PEREMPUAN USIA SUBUR TERHADAP PEMERIKSAAN IVA: Literature Review
Authors: Astikasari Diah
Published: September 2022

Kanker serviks yang disebabkan oleh virus HPV (Human Papiloma Virus) menyerang wania usia subur dan juga merupakan kankerdengan kejadian kasus terbesar. Untuk mengetahui faktor-faktor yang dapat memengaruhi kurang minat perempuan usiasubur terhadap pemeriksaan IVA.Jenis penelitian ini menggunakan literature review dengan teknik analisa menggunakan PiCoT dan artikel diperoleh dari databaseGoogle Schoolar, Pubmed dan Sciencedirect dengan menggunakan kata kunci dalam bahasa inggris “the factors that affecting,women of childbearing age, visual inspection with acetic acid, VIA examination” dan bahasa indonesia “ faktor-faktor yangmemengaruhi, perempuan usia subur, inspeksi visual asam asetat, pemeriksaan IV”. Kemudian dilakukan esktraksi databerdasarkan nama pengarang, tahun, negara, tujuan, reponden, desain, temuan.
A fluorescent photoaffinity probe for formyl peptide receptor 1 labelling in living cells
Authors: Field Devon , Warriner Stuart , Wright Megan
Published: September 2022

Fluorescent ligands for G-protein coupled receptors (GPCRs) are valuable tools for studying the expression, pharmacology and modulation of these therapeutically important proteins in living cells. Here we report a photocrosslinking fluorescent chemical probe for Formyl peptide receptor 1 (FPR1), a critical component of the innate immune response to bacterial infection and a promising target in inflammatory diseases. We demonstrate that the probe binds and covalently crosslinks to FPR1 with high specificity at nanomolar concentrations in living cells and is a useful tool for visualisation and characterisation of this receptor.
Advances in Honeycomb Layered Oxides: Part I - Syntheses and Characterisations of Pnictogen- and Chalcogen-Based Honeycomb Layered Oxides
Authors: Kanyolo Godwill , Masese Titus , Alshehabi Abbas , Huang Zhen-Dong
Published: September 2022

Advancements in nanotechnology continue to unearth material vistas that presage a new age of revolutionary functionalities replete with unparalleled physical properties and avant-garde chemical capabilities that promise sweeping paradigm shifts in energy, environment, telecommunications and potentially healthcare. At the upper echelons of this realm, the pnictogen and chalcogen class of honeycomb layered oxides have emerged with fascinating crystal chemistry and exotic electromagnetic and topological phenomena that muster multifaceted concepts spanning from materials science to condensed matter physics and potential applications in electrochemistry, quantum mechanics and electronics. In a bid to shed light on the mechanisms governing these biomimetic nanostructures, this review highlights the significant milestones and breakthroughs that have augmented their current knowledgebase of theory, properties and utilities. Herein, we elucidate the vast promising crystal chemistry space against the backdrop of known synthesis and characterisation techniques employed in the development and optimisation of this class of materials. Further, we highlight key theoretical models that have reinvigorated the exploration and characterisation of honeycomb layered oxides within this class and are poised to redefine the frontiers of material research and their applications. We conclude by envisaging future research directions where fascinating physicochemical, topological and electromagnetic properties could be lurking and where valiant efforts ought to be inclined, particularly in the prospective realisation of exotic material compositional space as well as their utility as testing grounds for emergent two-dimensional (2D) topological quantum gravity and conformal field theories.
Photoisomerization of phytochrome chromophore models: An XMS-CASPT2 study
Authors: Gopalakrishna Rao Aditya , Schapiro Igor
Published: September 2022

Phytochromes are a superfamily of photoreceptors that harbor linear tetrapyrroles as chromophores. Upon light illumination, the linear tetrapyrrole chromophore undergoes a double bond isomerization which starts a photocycle. In this work, we studied the photoisomerization of chromophore models designed based on the C- and D-rings of the phycocyanobilin (PCB) chromophore. In total, five different models with varying substitutions were investigated. Firstly, the vertical excitation energies were benchmarked using different computational methods to establish the relative order of the excited states. Based on these calculations, we computed the photoisomerization profiles using the extended multi-state (XMS) version of the CASPT2 method. The profiles were obtained for both the clockwise and counterclockwise rotations of the C15=C16 bond in the Z and E isomers using a linear interpolation of internal coordinates between the Franck-Condon and MECI geometries. In the minimal chromophore model that lacks the substitutions at the pyrrole rings, the isomerization involves both C14-C15 and C15=C16 bonds of the methine bridge between the C- and D-rings, resembling the hula-twist motion. The MECIs are characterized by a partial charge transfer between the two pyrrole rings pointing towards a twisted intramolecular charge transfer. Systematic introduction of substituents leads to an increase in the steric repulsion between the two pyrrole rings causing a pretwist of the dihedral around the C15=C16 bond, which creates a preference for the counterclockwise isomerization. Upon introduction of the carbonyl group at the D-ring the charge transfer has increased. This changes the isomerization mechanism from hula-twist to one-bond flip.
Machine Learning-Guided Discovery of New Electrochemical Reactions
Authors: Zahrt Andrew , Mo Yiming , Nandiwale Kakasaheb Y. , Shprints Ron , Heid Esther , Jensen Klavs
Published: September 2022

The molecular structures synthesizable by organic chemists dictate the molecular functions they can create. The invention and development of chemical reactions are thus critical for chemists to access new and desirable functional molecules in all disciplines of organic chemistry. This work seeks to expedite the exploration of emerging areas of organic chemistry by devising a machine-learning-guided workflow for reaction discovery. Specifically, this study uses machine learning to invent new electrochemical reactions. To this end, we first develop a novel molecular representation that enables the production of general models with limited training data. Next, we employ automated experimentation to test a large number of electrochemical reactions. These reactions are categorized as competent or incompetent mixtures, and a classification model was trained to predict reaction competency. This model is used to screen 38,865 potential reactions in silico and the predictions used to identify a number of new reactions of synthetic or mechanistic interest, 80 % of which are found to be competent. Additionally, we provide the predictions for the 38,865-member set in the hope of accelerating development of this field. We envision that adopting a workflow such as this could enable the rapid development of many fields of chemistry.
Understanding the capacity fade in polyacrylonitrile binder-based LiNi0.5Mn1.5O4 cells
Authors: Mathew Alma , Misiewicz Casimir , J. Lacey Matthew , Heiskanen Satu Kristiina , Mindemark Jonas , Berg Erik , Younesi Reza , Brandell Daniel
Published: September 2022

Binders are electrochemically inactive components that have a crucial impact on battery aging although being present in only small amounts, typically 1-3% w/w in commercial products. The electrochemical performance of a battery can be tailored via these inactive materials by optimizing the electrode integrity and surface chemistry. Polyacrylonitrile (PAN) for LiNi0.5Mn1.5O4 (LNMO) half-cells is here investigated as a binder material to enable a stable electrode-electrolyte interface. Despite being previously described in the literature as an oxidatively stable polymer, it is shown that PAN degrades and develops resistive layers within the LNMO cathode. We demonstrate continuous internal resistance increase in LNMO-based cells during battery operation using the intermittent current interruption (ICI) technique. Through a combination of on-line electrochemical mass spectrometry (OEMS) and X-ray photoelectron spectroscopy (XPS) characterization techniques, the degradation products can be identified as solid on the LNMO electrode surface, and no excessive gas formation is seen. The increased resistance and parasitic processes are correlated to side-reactions of the PAN, possibly intramolecular cyclization, which can be identified as the main cause of the comparatively fast capacity fade.
Dense and Acidic Organelle-Targeted Visualization in Living Cells using a Viscosity-Responsive Fluorescent Probe Independent of the Twisted Intramolecular Charge Transfer Process
Authors: Adachi Junya , Oda Haruka , Fukushima Toshiaki , Lestari Beni , Kimura Hiroshi , Sugai Hiroka , Shiraki Kentaro , Sato Kohei , Kinbara Kazushi
Published: September 2022

Cell-imaging methods with functional fluorescent probes are an indispensable technique to evaluate physical parameters in cellular microenvironments. In particular, molecular rotors, which take advantage of the twisted intramolecular charge transfer (TICT) process, have helped evaluate microviscosity. However, the involvement of charge-separated species in the fluorescence process potentially limits the quantitative evaluation of viscosity. Herein we developed viscosity-responsive fluorescent probes for cell imaging that are not dependent on the TICT process. We synthesized AnP2-H and AnP2-OEG, both of which contain 9,10-di(piperazinyl)anthracene, based on 9,10-bis(N,N-dialkylamino)anthracene that is an aggregation-induced emission luminogen (AIEgen). AnP2-H and AnP2-OEG exhibited enhanced fluorescence as the viscosity increased, with sensitivities comparable to those of conventional molecular rotors. In living cell systems, AnP2-OEG showed low cytotoxicity and, reflecting its viscosity-responsive property, allowed specific visualization of dense and acidic organelles such as lysosomes, secretory granules and melanosomes under washout-free conditions. These results provide a new direction for developing functional fluorescent probes targeting dense organelles.
Extension of Generic Amyloid Hypothesis to Metabolites of Urea Cycle and Uric Acid pathway
Authors: Patel Monisha , Gupta Shilpi , Joshi Aayushi , Wilson Basil , Pandey Manoj , Gour Nidhi
Published: September 2022

Herein, we report the aggregation properties of metabolites of urea cycle and uric acid pathway. The aggregation/ self-assembly properties of these metabolites were studied extensively via microscopic techniques. In this context the self-assembling properties of citrulline, ornithine, xanthine, hypoxanthine, cytosine and uracil were studied by assessing its aggregation under varying ageing time from fresh to day 15 of incubation. Interestingly, the metabolites exhibited tendency to aggregate and form soft fibril assembly during the course of ageing and gradually changes to crystalline structures on prolonged incubation. The results presented in this manuscript may have important implications in the pathogenesis of diseasescause urea and uric acid pathway metabolic dysfunction like HHH syndrome, Citrullinemia, Xanthinuria, Lesh Nyahn syndrome and Gout caused by accumulation of these metabolites.
Curación de contenidos científicos en medios sociales de revistas Iberoamericanas de Comunicación
Authors: Artigas Wileidys , Guallar Javier
Published: September 2022

Se presenta un estudio sobre el uso de la curación de contenidos en las publicaciones que realizan las revistas científicas de Comunicación de Iberoamérica en sus redes sociales. El motivo de la investigación es ayudar a conocer mejor las características y las formas que puede adquirir la curación de contenidos por parte de una revista científica en sus redes sociales. Se trata de una investigación descriptiva como método de investigación, que se apoya en las técnicas de investigación del análisis de contenido de los productos seleccionados, combinando una aproximación cuantitativa de la presencia de los ítems, y cualitativa en cuanto a su análisis y la extracción de ejemplos de buenas prácticas. Los resultados muestran el grado de presencia de las revistas iberoamericanas de Comunicación en redes sociales, el nivel de implantación de la curación en sus publicaciones, las principales temáticas y técnicas de las mismas y una serie de ejemplos de buenas prácticas que pueden servir de referentes para otras revistas. Entre las conclusiones se encuentran la baja presencia en redes sociales de las revistas estudiadas, la alta presencia de curación en sus publicaciones sobre los contenidos del último número publicado, así como anuncios diversos como temáticas mayoritarias, y el protagonismo de Comentar y de Resumir como técnicas de curación.
Polarización y discurso de odio con sesgo de género asociado a la política: análisis de las interacciones en Twitter
Authors: Blanco-Alfonso Ignacio , Rodríguez-Fernández Leticia , Arce-García Sergio
Published: September 2022

La propagación de discursos de odio a través de las redes sociales contribuye a intoxicar la esfera pública y a mermar la calidad de las democracias liberales. Este tipo de discursos es singularmente virulento contra la clase política y contra el feminismo. Partiendo de esta realidad, la presente investigación tratará de delimitar el sesgo de género en el discurso de odio en el ámbito político. ¿Reciben las mujeres políticas más agresiones verbales que sus homólogos varones, no por su condición de políticas, sino por su condición de mujeres? ¿Concentran las mujeres políticas más polaridad emocional que los hombres en las menciones que reciben en Twitter? A través del análisis del discurso operado con técnicas de PLN para la de detección de las emociones y de la minería de texto sobre un corpus de 3.483.232 de tuits recolectados de 20 cuentas de políticos españoles, se confirma que los mensajes que reciben las mujeres políticas concentran mayor polaridad emocional que los de los hombres, pero no más odio, que es un poco superior en los hombres. También se confirma que las expresiones sexistas y misóginas son empleadas para denigrar a las mujeres y, por extensión, al feminismo, lo que convierte al discurso del odio en un tipo de desorden informativo.
Testimoniales, endorsements y celebrities en publicidad. Un análisis empírico de las estrategias publicitarias en el Festival de Cannes, 2010-2020
Authors: Fernández Gómez Jorge David , Berenguel Fernández José , Macarro Tomillo Antonio
Published: September 2022

El presente trabajo aborda los conceptos de testimonial, endorsement y celebrity desde la estrategia publicitaria y la gestión de marca. Nuestro objetivo pasa por estudiar la forma en que los anunciantes y las empresas de publicidad han usado el testimonial y la figura de la celebridad con fines comerciales o corporativos en el contexto de la publicidad inscrita en el festival de Cannes de 2010 a 2020 en el ámbito iberoamericano. Para ello, se realizó un análisis de contenido de 280 piezas que además de cuantificar la presencia e implicaciones estratégicas del uso de las celebrities, también aportó datos y conclusiones sobre la técnica del endorsement y el uso de testimoniales publicitarios en general. Se analizó el posicionamiento estratégico, la tipología de objetivo, los tipos de testimonial, el modo de endorsement y las características de las celebrities. Los resultados arrojan que un 41,1% de los anuncios analizados han utilizado la figura del testimonial en sus commercials, destacando la persona corriente (62,1%), seguida por la celebridad (25,0%). Estratégicamente, predominan los objetivos híbridos (48,3%), los posicionamientos de usuario (55,17%) y atributos (42,2%) y el copresent mode como modo principal de endorsement, con un 89,3% de la muestra. De las características de las celebrities destaca la familiaridad/reconocimiento (76,9%), el carácter único/extraordinario (51,9%), la generación de interés (42,3%) y la fama (34,6%). El estudio concluyó la relevancia de los testimoniales en la publicidad iberoamericana, en el sentido de que los tipos de endorsements y el uso de testimoniales tienen implicaciones estratégicas muy interesantes para las marcas.
Descubriendo Netflix: identidad de marca y representaciones de la diversidad
Authors: Pedro Josep
Published: September 2022

Este artículo analiza la identificación estratégica de Netflix con la noción de diversidad, tanto fuera (off-screen) como dentro de la pantalla (on-screen). A partir de su comunicación pública, de informes sectoriales y de la literatura sobre el tema, se centra en examinar dos dimensiones: la relación entre diversidad, inclusión, política de empresa e identidad de marca Netflix, incidiendo en la diversidad de la fuerza laboral (off-screen); y la diversidad de sus contenidos a partir de la amplia categoría de Netflix Originals, considerando la diversidad de lugar, género y etnicidad o “raza” (on-screen). De este modo, el texto revela críticamente múltiples estrategias complementarias, empleadas crecientemente a nivel global para construir una identidad de marca vinculada a la diversidad en tanto valor positivo, reivindicado en el siglo XXI. Mediante esta identificación de marca con la diversidad, Netflix busca distinguirse tanto de la industria audiovisual tradicional como de sus competidores, lo cual contribuye a su hegemonía en el mercado global de vídeo bajo demanda.
Physicochemical, functional and sensory properties of wheat noodles substituted
by sorghum and mung bean flours
Authors: Wahjuningsih S.B. , Azkia M.N. , Kusumaningtyas R.W.
Published: September 2022

Noodles are flour-based processed products that are generally served as an alternative
food to carbohydrates dense products. Nowadays, carbohydrate-based processed products,
such as the production of non-wheat noodles and the substitution of non-wheat
carbohydrate sources, are developed, mainly through the use of local food commodities as
alternatives. The purpose of this research was to investigate the physicochemical qualities
of wheat noodles substituted for local food ingredients such as sorghum flour and green
beans via sticking properties, cooking quality, proximate analysis, and sensory
characteristics. Resistant starch and dietary fibre content were the functional features
studied. Five formulas were established, each with a different amount of wheat flour,
sorghum flour and mung bean flour used in the processing, namely N1 (50:20:30), N2
(40:30:30), N3 (30:40:30), N4 (20:50:30), and N5 (10:60:30). The peak viscosity of the
five composite flour formulae was 1421-1778, the breakdown value was 454-535, and the
ultimate viscosity was 1967-2490, with a cooking loss of 10.69-23.21%. According to
proximate analysis, the formulated noodles provide complete nutritional content to meet
nutritional adequacy, namely 375-381 kcal/100 g. It not only has a great nutritional value,
but it also has strong physiological advantages for the body due to the high concentration
of dietary fibre (9.6-9.8%) and resistant starch (14.93-15.01%). The taste, texture, and
aroma of the sample formulae N2, N3, and N5 are comparable to wheat-based noodles.
The five wheat noodles substituted by sorghum and mung bean flour formulations were
potentially developed into functional products with comprehensive nutritional content,
high dietary fibre, and resistant starch. Further research is needed to confirm its functional
properties on health.
Exploring the Psychological and Socio-Demographic Predictors of Pro-Environmental Behaviours Towards Forest Conservation in Brazil.
Authors:   , Mezencio Godinho Larissa
Published: September 2022

Deforestation has become a major issue facing Brazil. The constant loss of forests across the country has reached alarming levels. Encouraging Brazilians to engage in pro-environmental behaviours that support forest conservation is an urgent need. This thesis explores how Brazilians perceive forest conservation actions in the country. It also explores psychological and demographic factors as predictors of pro-environmental behaviours towards forest conservation, such as learning about environmental issues or signing petitions on forest conservation.

An online survey was distributed using the snowball sampling technique to obtain data from all five macro-regions of Brazil, which reached a total sample size of N=977. The main results demonstrated that Brazilians perceived deforestation as a major environmental issue facing the country and that local community engagement was the best solution to relieving the forest degradation caused by humans. However, not all participants believed themselves capable of acting for forest conservation. Connection with nature played an important role in predicting pro-environmental behaviours towards forest conservation. Concern about deforestation and a participant’s age were also significant predictors of pro-environmental behaviours towards forest conservation.

The findings of this thesis contribute to our understanding of public opinion about Brazilian’s forest conservation. Moreover, they advance the understanding of psychological and demographic factors enabling pro-environmental behaviours towards forest conservation in Brazil. They could help inform policies to mitigate human impacts on deforestation in Brazil.
The Women of Chicago Public Housing. Architects of their Own ‘Homeplace’
Authors: Siefert Rebecca
Published: September 2022

The story of public housing in Chicago, and the rest of the United States for that matter, tends to fixate on negative images of housing projects built between c. 1940-1960, like Cabrini-Green or Wentworth Gardens. Now that so many of the buildings have been demolished (or “redeveloped”) and scholars, institutions, and the general public have begun to untangle the complexity of the history of public housing in the U.S., it is time to move beyond the damaging narratives and negative imagery to better understand how women persevered and adapted to ensure they and their families not only had basic needs met, but also had access to safe spaces, key facilities, and opportunities for community-building, joy, and pride in their home. This paper explores connections between issues of architecture and the impact of women on the design and reform of Cabrini-Green, Wentworth Gardens, and other key examples, to demonstrate how women residents helped shape the built environment of public housing in Chicago through organizing, activism, and the appropriation of space based on everyday needs and use. Through an analysis of photographs documenting the interiors of Cabrini-Green and using a theoretical framework that combines feminist theorist bell hooks’ notion of the ‘homeplace’ as a ‘site of resistance’ (1990) with architectural historian Dell Upton’s concept of the ‘cultural landscape’ (1991), this paper proposes that we modify our current definition of an “Architect” and in fact consider these public housing residents ‘architects of their own homeplace’.
Fin de siglo en Alicante. La arquitectura y sus arquitectas (1990-1999)
Authors: Gutiérrez-Mozo María-Elia , Parra-Martínez José , Gilsanz-Díaz Ana
Published: September 2022

Comparada con otros territorios, la provincia de Alicante es un caso excepcional en el panorama español de finales del siglo XX por la cantidad y la calidad de obras de arquitectura realizadas por mujeres. En ella se dan cita reconocidas arquitectas alicantinas y autoras de renombre internacional que trabajan en equipo, a dúo, pero también en solitario, en las más diversas disciplinas y escalas, desde el paisajismo al diseño de interiores, desde los equipamientos a la arquitectura residencial. Este artículo se centra en un periodo particularmente efervescente en la construcción de la identidad (post)moderna del litoral alicantino y de unos años, los noventa, que fueron decisivos en la definición, tanto de los modos de hacer como de los relatos que dan cuenta o silencian la contribución de las mujeres al desarrollo de la cultura arquitectónica local. Desde un triple objetivo, la crítica historiográfica con perspectivas de género y generación, la cartografía de las arquitectas y sus prácticas y, por último, el análisis de proyectos que permitan desvelar algunos rasgos diferenciales de su producción, se aborda el caso de las dos únicas arquitectas afincadas en Alicante que entonces ya firmaban en solitario, Lola Alonso y Carmen Rivera. Esta investigación desvelaría las claves de un obstinado ejercicio de bitextualidad, es decir, de apropiación del discurso androcéntrico, pero también de su incuestionable compromiso con la arquitectura.
Oralidad editada: Reaprendiendo de las respuestas de Denise Scott Brown en la entrevista Relearning from Las Vegas
Authors: Cantero Vinuesa Antonio , Toro Ocampo Lina
Published: September 2022

En la elaboración de una historia de arquitectura más inclusiva, utilizar la historia oral como metodología para acceder a experiencias silenciadas, compartir conocimientos olvidados y trascender el constructo dibujado o construido, resulta esclarecedor. Es posible explorando el papel crucial pero en gran medida olvidado de las entrevistas arquitectónicas: no entrevistas de arquitectos, sino entrevistas hechas por arquitectos. En concreto, la entrevista Relearning from Las Vegas (2000), realizada por Rem Koolhaas en colaboración con Hans Ulrich Obrist a Robert Venturi y Denise Scott Brown. No es casual que los inicios de Koolhaas como entrevistador acontezcan en el Haagse Post, con procesos de edición que eran una herramienta de montaje de transcripciones centradas en lo impopular como ejercicio crítico. La oralidad editada le permite rediseñar el personaje, enfatizar lo que le interesa y eliminar lo que no construye el perfil buscado. Revalorizar algunas respuestas de Scott Brown supone dotar de un valor ensayístico y especulativo al contenido hablado e informal como fuente legítima para reivindicar contribuciones de la entrevistada. Estas prácticas editoriales contrastarán posturas al entrar en territorios resbaladizos de una disciplina que esquiva un realismo a voces para afrontar el futuro con una posición crítica.
La arquitectura social de Itziar González Virós: por una construcción democrática del espacio
Authors: Serra-Permanyer Marta
Published: September 2022

El artículo explora el significado de arquitectura social a partir del análisis del pensamiento y obra de la arquitecta barcelonesa Itziar González Virós (1967). La principal finalidad consiste en reflexionar sobre las características del diseño de procesos enfocados a la construcción democrática del espacio desde una doble significance: por una parte desde los puntos de encuentro con el pensamiento feminista, por el otro, desde la identificación de los rasgos de liderazgo femenino. A partir de la justificación del caso de estudio y de la aproximación metodológica, se presentan dos proyectos clave en la trayectoria de la arquitecta que servirán para ejemplificar las prácticas de arquitectura social: “Otra plaza Lesseps es posible” (2002) y “Les Rambles” (2017-2018). La discusión sobre la arquitectura social seguirá para escrutinar la doble valencia mencionada a través de reflexiones acerca el diseño hacia formas de relación igualitarias; la capacidad de agencia para acompañar cambios de modelo; el valor comunitario como elemento clave; y las barreras y potenciales derivados de los rasgos de liderazgo femenino. Así se concluye con la revisión y matización de las hipótesis de partida planteadas acerca de la noción de arquitectura social.
Transcultural Dwelling. Japan’s Pioneer Architect Miho Hamaguchi and her last Project in Spain
Authors: Gómez Lobo Noemí , Ueda Kana , Martín Sánchez Diego
Published: September 2022

Miho Hamaguchi (1915-1988) was the first woman to be a licensed architect in Japan. A pioneer in domestic design during the postwar period, she built and consulted on thousands of houses throughout her prolific career. However, she is a little-known figure both in Japan and in the international debate. Her representation in architectural historiography is limited to her influence on kitchen design, but her writings and work go far beyond. Hamaguchi's legacy is one of bold residential architecture that embodied democratic ideas in spatial configurations. She promoted the house as a fundamental tool for gender equality, leaving behind a feudal and patriarchal system. At the end of her career, she found in Costa del Sol the perfect place to carry out a residential project as a cultural exchange. "Kaiyo Club" became a set of three houses since the first design in 1974 until the subsequent extensions were completed in 1987. Throughout its different stages, the project shows a striking Spanish-Japanese transfer where different architectural languages coexist. The white-walled exterior dialogues with the vernacular, while its interior unfolds Japanese patterns with tatami-floored rooms or ofuro-style bathrooms. These dwellings present a unique hybrid materialization, displaying Hamaguchi's design from a humanistic stance, blending of locally rooted modernist spatial principles and reinterpreted traditions.
Listening to Unheard Voices in Urban Public Space. The Cases of Ruskin Square and Plaça d'en Baró
Authors: Ottaviani Dorotea , De Marinis Cecilia
Published: September 2022

The paper explores the concept of ‘listening to unheard voices’ in the urban environment as a design intention and strategy that contributes to an inclusive and alternative approach to urban public space, considering and promoting the imperatives of caring that such space should deliver to the city and its inhabitants. The ideas discussed in the paper find their background in the research on the concept of care in feminist urbanism and feminist studies in general, and specifically in relation to the model of the Caring City, promoting a city that places care at its centre, and aims to include a wider selection of citizens in the construction of the public good.
Through the analysis of two case studies of public spaces designed by solo-women architecture practices, this paper identifies an alternative relational paradigm which gives space to unheard voices in the urban environment through processes of inclusion and participation. The two cases, Plaça d'en Baró in Santa Coloma de Gramenet (Barcelona, Spain), designed by Catalan architectural collective Equal Saree, and Ruskin Square in the London Borough of Croydon (London, UK) designed by British architectural practice muf architecture/art, have implemented the concept of listening to ‘unheard voices’ offering insights into the contribution of women to the urban environment and how it is transformed, shaped, and used.
Expanding Agency. Women, Race and the Dissemination of Modern Architecture
Authors: James-Chakraborty Kathleen
Published: September 2022

Expanding Agency: Women, Race and the Dissemination of Modern Architecture is a five-year research project funded by a European Research Council Advanced Grant. It explores the role that women and members of ethnic minorities, primarily African Americans, played in transmitting modern architecture and design internationally between 1920 and 1970.  Strands devoted to patronage, journalism, entrepreneurship, and institution building offer alternatives to accounts that focus primarily on architects. This approach expands our understanding of who had agency in this important story and more generally in shaping the built environment. Taking a global view that stresses comparisons across continents also helps build a more nuanced history of how architecture, landscape architecture, interior decoration, and the design of furnishing were transformed by new ideas that emanated from a multiplicity of sources.  This in turn can help support a more diverse profession that, in the wake of #metoo and Black Lives Matter, is better prepared to engage with a broad public, including to address such social challenges as sustainability and the integration of migrants.
Early deaths associated with community-acquired and healthcare-associated bloodstream infections: a population-based study, Finland, 2004 to 2018
Authors: Kontula Keiju SK , Skogberg Kirsi , Ollgren Jukka , Järvinen Asko , Lyytikäinen Outi
Published: September 2022

Background

Bloodstream infections (BSI) cause substantial morbidity and mortality.

Aim

We explored the role of causative pathogens and patient characteristics on the outcome of community-acquired (CA) and healthcare-associated (HA) BSI, with particular interest in early death.

Methods

We used national register data to identify all BSI in Finland during 2004–18. We determined the origin of BSI, patients´ underlying comorbidities and deaths within 2 or 30 days from specimen collection. A time-dependent Cox model was applied to evaluate the impact of patient characteristics and causative pathogens on the hazard for death at different time points.

Results

A total of 173,715 BSI were identified; 22,474 (12.9%) were fatal within 30 days and, of these, 6,392 (28.4%) occurred within 2 days (7.9 deaths/100,000 population). The 2-day case fatality rate of HA-BSI was higher than that of CA-BSI (5.4% vs 3.0%). Patients who died within 2 days were older than those alive on day 3 (76 vs 70 years) and had more severe comorbidities. Compared with other BSI, infections leading to death within 2 days were more often polymicrobial (11.8% vs 6.3%) and caused by Pseudomonas aeruginosa (6.2% vs 2.0%), fungi (2.9% vs 1.4%) and multidrug-resistant (MDR) pathogens (2.2% vs 1.8%), which were also predictors of death within 2 days in the model.

Conclusions

Overrepresentation of polymicrobial, fungal, P. aeruginosa and MDR aetiology among BSI leading to early death is challenging concerning the initial antimicrobial treatment. Our findings highlight the need for active prevention and prompt recognition of BSI and appropriate antimicrobial treatment.
DEVELOPMENT OF ECOLOGICAL TOURISM IN RUSSIA. CONCEPTUAL CHARACTERISTICS AND POTENTIAL OF DEVELOPMENT
Authors:   Sochi State University, Tsepilova Elena S. , Rodionova Natal’ya D. ,   Rostov State University of Economics
Published: September 2022

The article considers conceptual issues of meaningful interpre- tation, the current state and prospects for further development of eco-tour- ism, with regard to environmental conservation and the rational exploitation of natural resources. In Russia, as a country with immense tourist and recre- ational potential, ecological tourism is becoming more and more in demand not only in specially protected natural areas, but also in regions that have never positioned themselves as tourist destinations before. However, a few legal, in- frastructural and organizational constraints and issues that prevent its more active development in Russia. The authors highlighted the conceptual charac- teristics of eco-tourism in comparison with terms similar in meaning – natural tourism, natural and educational tourism, green tourism, soft tourism. Legisla- tive consolidation of the definition of the term “ecological tourism” will allow to clearly identify that type of tourism, to form the industry professional re- quirements for its organization, to apply the best available technologies.
Uncommon series of subclavian vein thrombosis in Emergency Department
Authors: Jalali Rakesh , Pypkowska Agata , Szwed Weronika , Fadrowska Magdalena , Wasilewski Grzegorz , Zawadzki Andrzej , Manta Joanna
Published: September 2022

Introduction

Deep vein thrombosis (DVT) is one of the two possible clinical manifestations of venous thromboembolism (VTE), and the other one is the pulmonary embolism. The most common reasons behind the upper limb DVT can be central venous catheterization, compression of subclavian vein or anatomical abnormalities.

Aim

The aim of this study is to stress the importance of accurate diagnosis of the relatively rare subclavian vein thrombosis (SCVT). Due to low specificity of the clinical signs and symptoms, a careful risk assessment of VTE is extremely helpful in successfully reaching a diagnosis.

Case study

Authors are presenting a series of 4 cases of diagnosis and initial treatment in Emergency Department (ED) of the patients presenting with common symptoms of upper limb with uncommon SCVT. All patients presented to ED, of which 3 were seen in ED of our hospital and 1 patient, who is co-author of the publication, had the same diagnosis in other ED allocated in another city.

Results and discussion

Among the 4 patients only 1 has reached high risk in Caprini’s score and moderate in Wells score. In Padua scale patient did not reach high risk. In other patients risks in each score were low.

Conclusions

In most cases, the Wells, Padua, Caprini scores can be used to evaluate the risk of VTE; this diagnostic tool cannot be efficiently utilized in patients with local anatomical anomalies, which can lead to problems with diagnostics and treatment of such patients.