bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Usage Method of Durum Wheat Semolina in Bread Production
Authors: ÖZÜLKÜ Görkem
Published: August 2022

Durum buğdayı irmiği (DBİ), Türkiye’de daha çok makarna üretiminde kullanılmaktadır. Bu çalışmada DBİ, ekmek formülasyonuna belli oranlarda doğrudan (%7.5, %15 ve %22.5) ve aynı oranları sağlayacak şekilde ekşi hamur olarak ilave edilmiştir. Ekmeklik buğday unu ile %7.5, %15 ve %22.5 oranlarında ikame edilen DBİ, unun farinograf su absorbsiyon değerini azaltmıştır (p
Investigation of the usability of robots in mining operations
Authors: KÜLEKÇİ Gökhan , ÜNKER Faruk
Published: August 2022

With the developing technology, mobile robots have made impressive progress in various fields. Mines, one of the most tiring and potentially dangerous working environments for humanity, will be affected by this advance of mobile robots. Namely, with the robots that can replace the underground personnel in the mining sector, occupational accidents and costs can be significantly reduced. In disaster situations, rescue robots can help locate missing personnel. Unmanned machines operated only by robots do not endanger human life in any way. In this study, it is aimed to solve the balance problem in robots that can be produced for rescue, mapping or active working in underground mines. It is aimed that the robots to be produced using the new generation gyroscope will remain in balance under all conditions and be able to perform the given task in a healthy way.
Evaluation of the Potentiality of Wood and Processing Dust as Sustainable Raw Materials for 3 Dimensional (3D) Printers
Authors: CENGİZ Özgür , AKTEPE Şükriye
Published: August 2022

Three-Dimensional (3D) printing technology is constantly evolving. Recently, several alternative studies are being conducted for the materials used in 3D printers with the growth of technology in additive manufacturing. On the other hand, different materials for different applications could be produced by means of 3D printers. While focusing the materials that are widely used today are evaluated in terms of their potential of sustainability and high costs, several studies addressing the possibilities of alternative and additive material utilization possibilities are being carried out. As an alternative to the mentioned materials which are commonly used, it is thought that several waste materials can be used and that the utilization of these materials provides a contribution to the circular economy as well as the cost-effective production. In this study, two materials which have widespread industrial scale were evaluated for 3D printing applications; wood material that can be used as an additive or a filament in 3D printers and sawdust as a waste material obtained from production processes. Sawdust, which is advantageous in terms of being a sustainable material, also has the potential to be used as an additive in printers. It was observed that several creative designs for different areas of use have been made using sawdust material and the experiments have been evaluated. According to the results of the evaluated studies, the utilization areas of the materials were assessed. As a result of this study, design experiments of wood and sawdust as alternative materials in 3D printing applications and the utilization possibilities of the manufactured objects were discussed.
Makine Öğrenimi Kullanılarak Nehir Akım Tahmininde Uzun-Kısa Süreli Bellek ve Geçitli Tekrarlayan Birim Model Tabanlı Derin Öğrenme Modellerinin Karşılaştırılması
Authors: KILINÇ Hüseyin Çağan , POLAT Ahmet
Published: August 2022

Dünya nüfusundaki artış ve bunun sonucunda ortaya çıkan su ve enerji talebi, su kaynakları üzerinde artan bir baskı oluşturmaktadır. Makine öğrenmesi (ML), nehir akışlarını tahmin etmede etkin bir rol oynamaktadır. ML yöntemlerinden olan tekrarlayan sinir ağı (RNN) modeli, tekrarlayan veri setlerinde kaybolan gradyan sorunu nedeniyle yetersiz kalmıştır. Uzun kısa süreli bellek ağları (LSTM), ağ hücrelerinin önceden depolanmış belleklerinin bir kısmını unutmasına izin verir. Diğer bir yöntem olan geçitli tekrarlayan birim (GRU) ise hafızayı günceller ve kayıp problemini çözer. GRU'nun eğitim parametresi daha az olduğu ve daha az bellek kullandığı için hızlıdır, LSTM modelinde ise daha uzun diziler kullanıldığından veri kümesinde daha doğrudur. Fırat Nehri üzerindeki (E21A035) Bulam akış ölçüm istasyonunun (FMS) (2000-2009) akış verilerinden elde edilen veri seti orta büyüklükte ve tekrarlayan değerlere sahip olduğundan çalışmada bu iki model bu istasyondan elde edilen veriler ile karşılaştırılmıştır. Çalışma için Adadelta, Adagrad, FTRL, SGD, RMSprop, Nadam, Adamax, Adam iyileştiricileri test edilmiştir. R2, MAE, RMSE istatistiksel değerlendirme kriterleri göz önüne alındığında Adam ve Adamax optimize edicilerin daha iyi sonuçlar verdiği görülmüş ve verilere en uygun olan bu iyileştiricilerin kullanılmasına karar verilmiştir. Çalışmada MAE, MSE ve LogCosh kayıp fonksiyonları kullanılmıştır. LSTM ve GRU modellerinin performansı analiz edildiğinde, GRU modelinden daha iyi sonuçlar elde edildiği, 0.3346 RMSE, 0.1464 MAE ve 0.9718 R2 değerleri ile gözlemlenmiştir.
Elektrikli Araçlar için Aynı Stator Gövdesine Sahip Asenkron Motor ile Gömülü Sürekli Mıknatıslı Senkron Motorun Karşılaştırılması ve Performans Analizi
Authors: KARTAL Emin Tarik , KESKİN ARABUL Fatma
Published: August 2022

Electric motors are widely used since they are more efficient and environmentally friendly compared to internal combustion engines. Studies in the fields of electric motors and battery management systems etc. used in electric vehicles are increasing day by day. In this study, electric motor design and performance analyzes to be used in electric vehicles are made. Accordingly, firstly, an induction motor design is carried out by considering the design parameters of the induction motor used in Tesla Model S. Then, by taking the stator core of this induction motor as a reference, an interior permanent magnet synchronous motor design, which is very common and advantageous in electric vehicles, is designed. By considering the air gap, magnet angle, magnet thickness, magnet width and magnet type parameters of this motor, the results of analyzes are evaluated in terms of efficiency and torque ripple. As a result of analyzes, efficiency of the final design has been improved by 4.78% compared to the reference induction motor. In addition, the torque ripple of the final design has been improved by 55.17% compared to the initial design of the interior permanent magnet synchronous motor.
ANALYSIS OF TOTAL FLAVANOID LEVELS OF FENNEL LEAVES (FOENICULUM VULGARE) ETHANOL EXTRACT BY SPECTROPHOTOMETRY VISIBEL
Authors: Lindawati Novena Yety , Ni’ma Alifia
Published: August 2022

Flavonoid is the compounds in nature that play a role in increasing body immunity. Flavonoids in green plants can be sourced from fennel leaves. The aims of the study were to determine the total levels of flavonoids in fennel leaves (Foeniculum vulgare) using Visible Spectrophotometry. Maceration extracted samples using ethanol 96% solvent. Qualitative analysis of flavonoids using dilute NaOH, Wilstater-cyanidin method, and AlCl3. Quersetin used as standard solution. Quantitative analysis was carried out by colorimetric method with ALCl3 reagent as a complex compound. Quantitative analysis was continued with Visible Spectrophotometry on operating time at the 28th minute and a wavelength of 430.5 nm. Qualitative analysis indicate that the ethanol extract of fennel leaves was positive flavonoids. The total flavonoid content of fennel leaves ethanol extract was 99.2 mg QE/g extract with a coefficient of variation 1.27%.
FORMULATIONS AND PHYSICAL STABILITY TEST OF OLIVE OIL (Olea europaea L.) LIP BALM WITH ILLIPE BUTTER
Authors: Desnita Rise , Anastasia Desy Siska , Putri Mutiara Dinda
Published: August 2022

Lip balm is a preparation that is applied on the lips to protect the lips from damage. Olive oil is an oil that has emollient properties that are able to maintain moisture, flexibility, and smoothness in the skin. Oleic acid content in olive oil has the ability to improve skin permeability. Tengkawang fat is known to have characteristics similar to cocoa fat so it is used as a base. This study will provide an overview of the physical properties of olive oil lip balm (olive oil) with tengkawang fat based on storage for 28 days. Lip balm preparations are made in three concentration variations for 10%, 15%, and 20%, Then the preparation will be observed organoleptically changes, homogeneity of the preparation, pH and temperature of the melting point. The results ANOVA test of pH showed there was no significant difference between storage time to pH for each formula. Organoleptic and homogeneity test show good results in the absence of discoloration, odor, and texture and homogeneity during the storage period. The evaluation of lip balm preparations for each formula showed that the preparations were physically stable during the 28-day storage period.
ANALYSIS BETWEEN THE NUMBER OF ANTIHYPERTENSIVE WITH MEDICATION ADHERENCE IN END STAGE RENAL DISEASE
Authors: Ratnasari Pande Made Desy , Yani Ketut Lia Pran Anggar , Arini Heny Dwi
Published: August 2022

End-Stage Renal Disease (ESRD) is a condition of severe renal damage associated with a higher incidence of hypertension that requires antihypertensive therapy to prevent the worsening disease. Therefore, patients who received more than two types of antihypertensives have affected medication adherence. This study aimed to analyze relationship between the number of antihypertensives and medication adherence in ESRD patients. The study was a cross-sectional design involving 77 participants selected by a purposive sampling technique at Outpatient Private Hospital Buleleng Bali in July-September 2020. Data were collected based on patient’s medical records and the Probabilistic Medication Adherence Scale (ProMAS) questionnaire. The inclusion criteria were ESRD patients aged ≥18 years, with hypertension history, taking the same antihypertensive for three months before the study, sign informed consent, and completed medical record data. Those who were a weak general condition and cognitive impairment were excluded from the study. Data were analyzed using a Kruskal-Wallis test. The results showed that overall, of patients were <65 years old (80.52%), male (70.13%), duration of ESRD <5 years (89.61%), primarily high school (57.14%), and without complications (57.1%). Most patients used a combination of two antihypertensives (35.07%), and 61.04% has a high medication adherence. There was no significant relationship between the number of antihypertensives and medication adherence (p=0.847). Nevertheless, it was still shown that the higher number of antihypertensives in ESRD patients was directly proportional to the lower medication adherence.
FORMULATION OF CHEWABLE TABLET PREPARATIONS FROM THE COMBINATION OF Azadirachta Indica A. Juss. AND Gynura Procumbens (Merr.)
Authors: Pratama Nofran Putra , Purnomo Sari Kurnia Rahayu , Kurniawati Endah
Published: August 2022

Azadirachta indica A. Juss. and Gynura procumbens (Merr.) are one type of potential medicinal plants because they have various properties. One of the properties of these two plants is as an antioxidant. The combination of the two plants has a strong category of antioxidant activity, does not cause death and physical changes in test animals. This study aimed to make an antioxidant chewable Tablet containing a combination of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) extract with a variation of mannitol-sorbitol as a filler. This variation has the advantage of covering the bitter taste of the active substance so that it is expected to provide a pleasant taste and is easy to swallow. The extract obtained was formulated into chewable Tablets with variations of mannitol-sorbitol (90%:10%), (80%:20%), and (70%:30%). The method used is wet granulation. The granules obtained were tested for their physical properties, namely flow velocity, angle of repose, and compressibility. The physical properties of the Tablets tested included uniformity of weight, size, hardness, friability, disintegration time, quality of taste, shape, and odor. Based on the test results of the physical properties of the granules, the three formulas met the requirements. While the physical properties of Tablets that do not meet the criteria are uniformity of size and disintegration time. This research concludes that the extracts of Azadirachta indica A. Juss. and Gynura procumbens (Merr.) be formulated into chewable Tablets where formula two with variations of mannitol:sorbitol (80:20%) is the best formula by fulfilling 9 of 11 requirements
PHYTOCHEMICAL ANALYSIS AND TOTAL FLAVONOID CONTENT ON ETHANOL AND ETHYL ACETATE EXTRACT FROM NEEM (AZADIRACHTA INDICA JUSS.) LEAVES UTILIZING UV–VIS SPECTROPHOTOMETRIC
Authors: Widiyana Anita Puspa , Illian Didi Nurhadi
Published: August 2022

The plants are rich sources of secondary metabolites, a bioactive compound that has various activities. Flavonoids, as a type of secondary metabolite, have been reported to possess anticancer, antioxidant, antibacterial, anti-inflammatory, and antiviral activities. Flavonoid has been found abundantly in Neem (Azadirachta indica Juss.) leaves. The difference in total flavonoid content might be an occurrence of the different solvent types and concentrations. The present study was conducted to analyze the phytochemical and determine the total flavonoid content of neem leaves extract using two different solvents (namely 70% ethanol and ethyl acetate) using UV-Vis spectrophotometric. The extraction from neem leaves was performed by maceration method. Phytochemical analysis of neem leaves reveals several secondary metabolites: flavonoids, steroids/triterpenoids, tannins, and saponins. Total flavonoid content from both extracts was determined by utilizing the UV-Vis spectrophotometric method at a maximum wavelength of 428.2 nm with three repetitions, and also quercetin was used as a standard. Total flavonoid content from neem leaves extract in solvents of 70% ethanol and ethyl acetate had a value of 118.57 ± 0.08 mg/g QE and 74.17 ± 0.20 mg/g QE, respectively. Neem leaves extract in solvents of 70% ethanol and ethyl acetate had identical phytochemical content. Total flavonoid content of neem leaves from 70% ethanol extract was higher than ethyl acetate extract.
THE EFFECT OF BETEL LEAF EXTRACT SPRAY ON HISTOPATHOLOGY OF WOUND HEALING
Authors: Nurani Laela Hayu , Sikumbang Isabella Meliawati , Yuliani Sapto , Edityaningrum Citra Aryani
Published: August 2022

Wounds are referred to as 'Silent Epidemic' because they have a substantial impact if not treated properly. Betel leaf is known to contain compounds that may be used as wound healers. The purpose of this study was to test the spray activity of betel leaf extract (Piper betle L) in healing acute wounds in male Balb/C mice. Spray formula made with various concentrations of betel leaf extract by 3% (S1), 5% (S2) and 7% (S3). The acute wound healing activity test was 15 mice divided into 5 groups S1, S2, S3, P (positive control), and C (negative control). Interventions and observations were carried out for 14 days. The results of observational analysis by calculating the ratio of wound area then One Way Anova test and Post Hoc Tukey Cramer test. The results showed that spray of betel leaf extract with a concentration of 7% was not significantly different from P (p>0.05). The conclusion in this study is that sprays of betel leaf extract 3%, 5%, and 7% may be used as an acute wound healer, the best healing activity is shown at a concentration of 7%.
Prise en charge d’un patient drépanocytaire aux urgences
Authors: Kassasseya C. , Bressand S. , Khellaf M.
Published: August 2022

La drépanocytose est aujourd’hui la première maladie génétique en France avec environ 30 000 patients adultes. Une mutation ponctuelle sur le chromosome 11 conduit à la production d’une hémoglobine pathologique qui polymérise sous l’effet de facteurs endo-ou exogènes induisant la falciformation des globules rouges à l’origine d’une vasoocclusion artérielle dont une des conséquences est l’oblitération des vaisseaux à destinée osseuse. Les infarctus osseux sont particulièrement douloureux, conduisant les patients aux urgences où l’enjeu est de soulager rapidement les douleurs par l’utilisation de morphine principalement par analgésie autocontrôlée après titration morphinique. Le risque majeur au cours de ces crises vaso-occlusives (CVO) est l’apparition d’un syndrome thoracique aigu (STA) pouvant mettre en jeu le pronostic vital du patient. La spirométrie incitative est un moyen préventif du STA important à instituer dès les urgences. Une antibiothérapie sera mise en place en cas de fièvre chez ces patients aspléniques à risque d’infections à germes encapsulés notamment par le pneumocoque. L’échange transfusionnel est une des pierres angulaires du traitement des CVO ou du STA mais le risque d’accident hémolytique aigu post transfusionnel doit en limiter l’usage à des situations mettant en jeu le pronostic vital ou fonctionnel d’organe. Plusieurs scores clinicobiologiques permettent de décider de l’utilité d’un angioscanner thoracique au cours du STA à la recherche d’une embolie pulmonaire ou pour décider de la pertinence d’une sortie vers une hospitalisation à domicile (Programme DREPADOM). L’utilisation de la morphine en dehors de l’hôpital de façon prolongée doit être prudente en raison du risque d’addiction.
Projected timeline to achieve gender balance within the United States neurosurgical workforce exceeds 150 years: a National Plan and Provider Enumeration System analysis
Authors: Mulligan Kathleen M. , Jella Tarun K. , Cwalina Thomas B. , Tsai Eve C. , Parr Ann M. , Woodrow Sarah I. , Wright James M. , Wright Christina H.
Published: August 2022

OBJECTIVE

Despite incremental progress in the representation and proportion of women in the field of neurosurgery, female neurosurgeons still represent an overwhelming minority of the current US physician workforce. Prior research has predicted the timeline by which the proportion of female neurosurgery residents may reach that of males, but none have used the contemporary data involving the entire US neurosurgical workforce.

METHODS

The authors performed a retrospective analysis of the National Plan and Provider Enumeration System (NPPES) registry of all US neurosurgeons to determine changes in the proportions of women in neurosurgery across states, census divisions, and census regions between 2010 and 2020. A univariate linear regression was performed to assess historical growth, and then Holt-Winter forecasting was used to predict in what future year gender parity may be reached in this field.

RESULTS

A majority of states, divisions, and regions have increased the proportion of female neurosurgeons from 2010. Given current growth rates, the authors found that female neurosurgeons will not reach the proportion of women in the overall medical workforce until 2177 (95% CI 2169–2186). Furthermore, they found that women in neurosurgery will not match their current proportion of the overall US population until 2267 (95% CI 2256–2279).

CONCLUSIONS

Whereas many studies have focused on the overall increase of women in neurosurgery in the last decade, this one is the first to compare this growth in the context of the overall female physician workforce and the female US population. The results suggest a longer timeline for gender parity in neurosurgery than previous studies have suggested and should further catalyze the targeted recruitment of women into the field, an overhaul of current policies in place to support and develop the careers of women in neurosurgery, and increased self-reflection and behavioral change from the entire neurosurgery community.
A standardized infection prevention bundle for reduction of CSF shunt infections in adult ventriculoperitoneal shunt surgery performed without antibiotic-impregnated catheters
Authors: Muram Sandeep , Isaacs Albert M. , Sader Nicholas , Holubkov Richard , Fong Annie , Conly John , Hamilton Mark G.
Published: August 2022

OBJECTIVE

Ventriculoperitoneal (VP) shunt insertion and revision surgeries are some of the most common procedures that are performed by neurosurgeons. Shunt infections within the adult population are associated with significant morbidity and mortality and rates remain high. The objective of the current study was to use quality improvement (QI) methodology to create a standardized infection prevention bundle aimed at reducing the rate of shunt infections.

METHODS

A prospective, single-center, single-surgeon QI study was undertaken. Patients were included if they were 18 years of age or older and were undergoing a VP shunt insertion or revision. The primary outcome of the study was the development of a shunt-related surgical site infection, within 1 year of surgery, as defined according to the Canadian Nosocomial Infection Surveillance Program guidelines. There was no standardized protocol prior to July 2013. A bundle coined as the Calgary Adult Shunt Infection Prevention Protocol (CASIPP) was implemented on July 1, 2013, and updated on July 1, 2015, when 2% chlorhexidine gluconate in 70% isopropyl alcohol replaced povidone-iodine for preoperative skin antisepsis. Protocol compliance was regularly monitored using a standardized process. No antibiotic-impregnated catheters were used.

RESULTS

A total of 621 consecutive VP shunt insertions and revisions were included in the study. The rate of shunt infection was 5.8% during the period in which there was no standardized shunt protocol. After the implementation of the CASIPP the infection rate decreased to 4.0%, and after introduction of the chlorhexidine/alcohol skin antisepsis, the infection rate was 0% in 379 consecutive procedures (p < 0.0001). Multivariable logistic regression analysis demonstrated that the use of chlorhexidine/alcohol with CASIPP was associated with a significant reduction in the odds of developing a shunt infection (OR 0.032, 95% CI 0–0.19, p = 0.0005).

CONCLUSIONS

The implementation of a standardized shunt infection prevention bundle within the adult population, without the use of antibiotic-impregnated catheters, significantly reduced the rate of shunt infections which was sustained over many years. The use of 2% chlorhexidine gluconate in 70% isopropyl alcohol for preoperative antisepsis may have played a significant role. Multicenter studies should be completed to verify the effectiveness of the authors’ protocol.
Cost-effectiveness analysis of radiosurgical capsulotomy versus treatment as usual for treatment-resistant obsessive-compulsive disorder
Authors: Najera Ricardo A. , Gregory Sean T. , Shofty Ben , Anand Adrish , Gadot Ron , Youngerman Brett E. , Storch Eric A. , Goodman Wayne K. , Sheth Sameer A.
Published: August 2022

OBJECTIVE

Stereotactic radiosurgical capsulotomy (SRS-C) is an effective neurosurgical option for patients with treatment-resistant obsessive-compulsive disorder (TROCD). Unlike other procedures such as deep brain stimulation and radiofrequency ablation, the cost-effectiveness of SRS-C for TROCD has not been investigated. The authors herein report the first cost-effectiveness analysis of SRS-C for TROCD.

METHODS

Using a decision analytic model, the authors compared the cost-effectiveness of SRS-C to treatment as usual (TAU) for TROCD. Treatment response and complication rates were derived from a review of relevant clinical trials. Published algorithms were used to convert Yale-Brown Obsessive Compulsive Scale scores into utility scores reflecting improvements in quality of life. Costs were approached from the healthcare sector perspective and were drawn from Medicare reimbursement rates and available healthcare economics data. A Monte Carlo simulation and probabilistic sensitivity analysis were performed to estimate the incremental cost-effectiveness ratio.

RESULTS

One hundred fifty-eight TROCD patients across 9 studies who had undergone SRS-C and had at least 36 months of follow-up were included in the model. Compared to TAU, SRS-C was more cost-effective, with an estimated incremental cost-effectiveness ratio of $28,960 per quality-adjusted life year (QALY) gained. Within the 3-year time horizon, net QALYs gained were greater in the SRS-C group than the TAU group by 0.27 (95% CI 0.2698–0.2702, p < 0.0001). At willingness-to-pay thresholds of $50,000 and $100,000 per QALY, the Monte Carlo simulation revealed that SRS-C was more cost-effective than TAU in 83% and 100% of iterations, respectively.

CONCLUSIONS

Compared to TAU, SRS-C for TROCD is more cost-effective under a range of possible cost and effectiveness values.
Equity in neurosurgery: a worldwide survey of women neurosurgeons
Authors: Koutsouras George W. , Zhang Lu , Zanon Nelci , Lam Sandi , Boop Frederick A. , Tovar-Spinoza Zulma
Published: August 2022

OBJECTIVE

The global neurosurgery workforce does not have a defined stance on gender equity. The authors sought to study and characterize the demographic features of the international women neurosurgery community and to better understand the perceptions and reflections of their neurosurgical careers. The objective was to define and characterize the workplace inequities faced by the global women neurosurgeon community.

METHODS

A 58-item cross-sectional survey was distributed to the global women neurosurgery community. The survey was distributed via an online and mobile platform between October 2018 and December 2020. Responses were anonymized. The authors utilized chi-square analysis to differentiate variables (e.g., career satisfaction) between various groups (e.g., those based on academic position). The authors calculated 95% CIs to establish significance.

RESULTS

Among 237 respondents, approximately 40% were between the ages of 26 and 35 years. Within their respective departments, 45% identified themselves as the only woman neurosurgeon in their practice. Forty-three percent stated that their department supported women neurosurgeons for leadership roles. Seventy-five percent of respondents were members of organized neurosurgery professional societies; of these, 38% had been involved in leadership roles. Almost 60% of respondents postponed their decision to get pregnant because of resident or work-related influences.

CONCLUSIONS

This survey provides international feedback for characterizing and understanding the experiences of women neurosurgeons worldwide. Future research should aim to understand all neurosurgeons’ experiences throughout the pipeline and career life cycle of neurosurgery in order to improve the field of neurosurgery.
Effect of spinach-derived glutathione against carbon tetrachloride-induced stress in rats
Authors: Abdulkareem Abdulrazak Enas , Jameel Oaswaa Yousif
Published: August 2022

Background: Increased consumption of natural antioxidants found in vegetables and fruits has been linked to a lower risk of disease caused by oxidative stress.Objective: The current study's focus was to compare the antioxidant properties of synthetic glutathione and glutathione derived from spinach against CCl4-induced stress in female albino rats. Materials and Methods: Cold chloroform extraction was used to prepare the spinach leaf extract. Glutathione was then extracted from the spinach leaf extract using preparative HPLC afterward when the concentration of glutathione was measured in the extract. Biological preventive and therapeutic experiments were conducted, where laboratory rats were divided into 6 groups, the first group G1 (positive control group), the second group G2 (negative control group), the third group G3 preventive experiment 1 (group glutathione extracted from spinach + CCl4), the fourth group G4 therapeutic experiment 1 (Group CCl4+ Glutathione extracted from spinach), the fifth group G5 Preventive experiment 2 (Group of synthetic glutathione + CCl4), the sixth group G6 therapeutic experiment 2 (Group CCl4+ Glutathione extracted from spinach). Results: Treatment of rats with spinach-derived synthetic glutathione, before or after they were given CCl4 subcutaneous, improved the values of parameters near to normal levels in the positive control animals in groups treated with spinach-derived glutathione (G3 and G4) compared to treatment with synthetic glutathione (G5 and G6). Administration of milk with glutathione derived from Iraqi spinach leaves exhibited favorable effects on oxidative stress, greatly enhanced the antioxidant system, and protected rats from liver damage brought on by carbon tetrachloride compared to milk with synthetic glutathione. Keywords: Iraqi spinach, Functional food, Natural antioxidant, Oxidative stress, synthetic glutathione.
LİSANSÜSTÜ TEZLERİN SONUÇ BÖLÜMLERİNDE ÜSTSÖYLEM BELİRLEYİCİLERİ
Authors: SOYŞEKERCİ Gökhan , AYDIN ÖZTÜRK Esra , İŞERİ Kamil
Published: August 2022

Bilimsel söylem, yazar ile okuyucular arasında etkileşimin gerçekleştirildiği alanlar sağlama eğilimindedir. Üstsöylem, tarafların ilişki kurup etkileşime geçmesini sağlayan araçlar setidir. Metnin tutarlığının korunmasını sağlayan, yazar ve okuyucu arasındaki etkileşime odaklanan dilsel özelliklerdir. Üstsöylem belirleyicileri ile yazarlar, metinde kendilerini yansıtarak konumlarını belirleyebilir, iletişimsel niyetlerini sergileyebilir, okuyucularını etkileyebilir ya da kaçınma ifadelerini kullanabilmektedir (Hyland, 1998b, 2005a, 2005b). Yazarın kendi duruşu ile ilgili metnin içeriğine, söylemin düzenlenişine ve okuyucuya açıkça gönderimlerde bulunduğu görünümler olarak tanımlanan (Hyland, 1998b, s. 438) üstsöylem, yazarın okuyucusu ile etkili bir iletişim kurmasını sağlamaktadır. Üstsöylem özellikle dilbilim ve (yabancı) dil öğretimi alanlarında büyük ilgi görmekte ve özellikle son dönemlerde üstsöylem ile ilgili çalışmaların giderek arttığı gözlemlenmektedir. Bu çalışmanın amacı, dilbilim alanında yazılan lisansüstü tezlerin sonuç bölümlerinde kullanılan üstsöylem belirleyicilerini tespit etmektir. Yükseköğrenim Kurulu Başkanlığı, Ulusal Tez Merkezi’nde 2001-2021 yılları arasında dilbilim alanında Türkçe yazılmış 241 lisansüstü tez arasından orantılı örnekleme yöntemi ile seçilen 72 lisansüstü tez, çalışmanın örneklemi olarak belirlenmiştir. Çalışma nitel araştırma yöntemi ile yapılandırılmıştır. Veriler nitel veri toplama tekniklerinden belge tarama yoluyla elde edilerek Hyland (2005a)’in oluşturduğu üstsöylem modeli ile çözümlenmiştir. Çalışmanın sonucunda üstsöylem belirleyicilerinin yüksek lisans ve doktora tezlerinde nasıl bir görünüm sergilediği tartışılmış ve yorumlanmıştır.
Investigating Intertrade Durations using Copulas: An Experiment with NASDAQ Data
Authors: Chakravarty Ranjan R. , Pani Sudhanshu
Published: August 2022

The pattern of dependence between liquidity, durations (orders and trades) and bid-ask spreads in a limit order market are examined in high resolution invoking copulas and graph theory. Using intraday data from a sample of NASDAQ 100 stocks and an experimental design, we study the information pathways in markets in the presence of algorithmic traders. Our results confirm that multivariate analysis is more appropriate to investigate these information pathways. We observe that the strength and nature of the dependence between variables vary through the trading day. We confirm the existence of stylised aspects of algorithmic trading, such as tail dependence in trade durations, a balance between buy and sell side in order durations, liquidity and bid-ask spreads, and the bid-ask spread and liquidity trade-off in the dependence structure.
RETRACTED: A review on modeling tumor dynamics and agent reward functions in reinforcement learning based therapy optimization
Authors: Almásy Márton György , Hörömpő András , Kiss Dániel , Kertész Gábor
Published: August 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Information structures in a multiset-valued information system with application to uncertainty measurement
Authors: Huang Dan , Lin Hai , Li Zhaowen
Published: August 2022

Information system (IS) is a significant model in the field of artificial intelligence. Information structure is not only a research direction in the field of granular computing (GrC), but also an important method to study an IS. A multiset-valued information system (MVIS) refers to an IS where information values are multisets. A MVIS can be seen as a model that is the result of information fusion of multiple categorical ISs. This model helps deal with missing values in the dataset. This paper studies information structures in a MVIS on the view of GrC and consider their application for uncertainty measurement (UM). First of all, some notions of multisets and probability distribution sets (PDSs) are proposed. Naturally, relationships between multisets and PDSs are researched. Then, the concept of a MVIS based on the notion of multisets is given, and the internal structure of a MVIS is revealed by an incomplete information system (IIS). Furthermore, tolerance relations in a MVIS are defined by using Hellinger distance, and tolerance classes are obtained to construct the information structures of a MVIS. Considering the association of information structures, relationships between information structures are raised from the two aspects of dependence and separation. Moreover, some properties between information structures are provided by using information distance and inclusion degree. Finally, four UMs as the applications of information structures are investigated, and comprehensive experiments on several datasets demonstrate the feasibility and superiority of the proposed measures. These results will be helpful for establishing a framework of GrC in a MVIS and studying UM.
RETRACTED: Genetic algorithm-based adaptive weighted fuzzy logic control (awFLC) for traction power control
Authors: Ekmekci Dursun , Shahbazova Shahnaz N.
Published: August 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
TOPSIS methods for probabilistic hesitant fuzzy multiple attribute group decision-making and application to performance evaluation of public charging service quality
Authors: Qi Quan-Song
Published: August 2022

The performance evaluation of public charging service quality is frequently viewed as the multiple attribute group decision-making (MAGDM) issue. In this paper, an extended TOPSIS model is established to provide a new means to solve the performance evaluation of public charging service quality. The TOPSIS method integrated with FUCOM method in probabilistic hesitant fuzzy circumstance is applied to rank the optional alternatives and a numerical example for performance evaluation of public charging service quality is used to test the newly proposed method’s practicability with the comparison with other methods. The results display that the approach is uncomplicated, valid and simple to compute. The main results of this paper: (1) A novel PHF-TOPSIS method is proposed; (2) The extended TOPSIS method is developed in the probabilistic hesitant fuzzy environment; (3) The FUCOM method is used to obtain the attribute weight; (4) The normalization process of the original data has adapted the latest method to verify the precision; (5) The built models and methods are useful for other selection issues and evaluation issues.
Feasibility of the community-based Stay at Work Intervention (SAWI) for stroke survivors
Authors: Turner Alyna , De Wet Theunis Jacobus , McMurray Jade , Wrobel Anna , Smith Heather , Clissold Ben , Mohebbi Mohammadreza , Kneebone Ian
Published: August 2022

BACKGROUND: Rates of stroke in people of working age are increasing. Returning to work (RTW) after stroke is a key rehabilitation aspiration for younger stroke survivors. A pilot community-based Stay at Work Initiative (SAWI) was developed and delivered from March 2017 to December 2019. SAWI used a co-ordination based approach, covering rehabilitation and vocational recovery to support RTW in younger stroke survivors. OBJECTIVE: The aim of the study was to conduct a feasibility evaluation of SAWI. METHODS: A mixed methods approach was taken considering quantitative and qualitative data. Quantitative data included employment, mood, anxiety and fatigue outcomes at time of engagement with the service and at 6-months post-stroke. Qualitative data was collected on a sub-sample of SAWI clients who volunteered to participate in a semi-structured interview. RESULTS: Overall, there were 93 referrals to SAWI, with 42 clients completing an initial service meeting. Average working hours pre-stroke were high (mean 46.9, SD 22.0, range 5–100 hours/week). By 6 months post stroke, 71% (n = 29 of 41) of SAWI clients were working. For those with 6-month questionnaire information (n = 19), there was a significant reduction in cognitive fatigue, overall fatigue levels, and perceived impact of stroke on employment (medium effect sizes of r = 0.36, 0.34 and 0.40 respectively). No significant difference was seen on measures of mood or anxiety from pre- to post-intervention. Qualitative interviews with six SAWI participants highlighted the importance of personalised support that addresses individual needs during the RTW journey. CONCLUSIONS: A significant number of eligible participants referred to SAWI can engage with the service. RTW is able to be assessed as are potential predictor variables. Seventy one percent of participants had RTW at 6 months post-stroke. Mood, self-efficacy, adjustment, and fatigue likely impact RTW. Qualitative interviews identified that SAWI’s personalised support, tailored to individual need, was valued.
The value of CT radiomics features to predict visceral pleural invasion in ≤3 cm peripheral type early non-small cell lung cancer
Authors: Wei Shu-Hua , Zhang Jin-Mei , Shi Bin , Gao Fei , Zhang Zhao-Xuan , Qian Li-Ting
Published: August 2022

OBJECTIVE: To investigate predictive value of CT-based radiomics features on visceral pleural invasion (VPI) in ≤3.0 cm peripheral type early non-small cell lung cancer (NSCLC). METHODS: A total of 221 NSCLC cases were collected. Among them, 115 are VPI-positive and 106 are VPI-negative. Using a stratified random sampling method, 70% cases were assigned to training dataset (n = 155) and 30% cases (n = 66) were assigned to validation dataset. First, CT findings, imaging features, clinical data and pathological findings were retrospectively analyzed, the size, location and density characteristics of nodules and lymph node status, the relationship between lesions and pleura (RAP) were assessed, and their mean CT value and the shortest distance between lesions and pleura (DLP) were measured. Next, the minimum redundancy-maximum relevance (mRMR) and least absolute shrinkage and selection operator (LASSO) features were extracted from the imaging features. Then, CT imaging prediction model, texture feature prediction model and joint prediction model were built using multifactorial logistic regression analysis method, and the area under the ROC curve (AUC) was applied to evaluate model performance in predicting VPI. RESULTS: Mean diameter, density, fractal relationship with pleura, and presence of lymph node metastasis were all independent predictors of VPI. When applying to the validation dataset, the CT imaging model, texture feature model, and joint prediction model yielded AUC = 0.882, 0.824 and 0.894, respectively, indicating that AUC of the joint prediction model was the highest (p < 0.05). CONCLUSION: The study demonstrates that the joint prediction model containing CT morphological features and texture features enables to predict the presence of VPI in early NSCLC preoperatively at the highest level.
ЗМІСТ І СТРУКТУРА ДИСЦИПЛІНИ “ПАКЕТИ ПРИКЛАДНИХ ПРОГРАМ”
Authors: БІЛИК Вікторія
Published: August 2022

Статтю присвячено дослідженню актуальності інтеграції освітніх та інформаційних технологій в освітньому процесі в умовах професійної підготовки майбутніх бакалаврів образотворчого мистецтва, декоративного мистецтва. Зазначено необхідність формування у здобувачів вищої освіти інформаційної культури, здатності використовувати сучасні інформаційно-комп’ютерні технології у майбутній професійній діяльності в галузі освіти й образотворчого та декоративного мистецтва. Представлено послідовність формування змісту і структури обов’язкової навчальної дисципліни загальної підготовки “Пакети прикладних програм”. Зазначено, що зміст і структура дисципліни відображається у робочій програмі навчальної дисципліни. Розроблення робочої програми здійснюється відповідно до вимог стандарту вищої освіти першого (бакалаврського) рівня зі спеціальності 023 Образотворче мистецтво, декоративне мистецтво, реставрація, освітньо-професійної програми “Образотворче мистецтво, декоративне мистецтво”, нормативних документів Хмельницького національного університету: методичних рекомендацій зі складання й оформлення робочих програм навчальних дисциплін та їх описів, положення із описом процедур контролю і оцінювання результатів навчання здобувачів вищої освіти в університеті тощо. Зміст та структуру дисципліни “Пакети прикладних програм” сформовано відповідно до таких етапів: визначено відповідність програмних компетентностей та програмних результатів навчання освітньо-професійної програми зазначеній навчальній дисципліні; сформульовано мету, завдання вивчення дисципліни і очікувані результати навчання із використанням дієслів прямої дії відповідно до рівня засвоєння, що базуються на класифікації Б. Блума; сформовано зміст і структуру освітнього компонента в межах обсягу дисципліни.
PECULIARITIES OF FORMING FUTURE SECURITY AND DEFENSE SECTOR OFFICERS’ SOCIAL AND COMMUNICATIVE COMPETENCE
Authors: БІНДЕР Наталія , ДЕМ'ЯНЮК Юрій , КРАВЧЕНКО Олександр
Published: August 2022

The article deals with the peculiarities of forming future security and defense sector officers’ social and communicative competence. New state educational standards have been implemented. They considered competence approach to be the main methodological approach of modern higher education. Within the competence approach, the focus is on the outcome of education, which is considered not as the amount of learned information and the set of acquired skills, but as the ability to act in different situations, including problematic and non-standard ones, showing a sufficient level of competence. It is emphasized that modern graduates’ knowledge, skills and abilities are characterized by a set of their key social and communicative competencies.In the article the author gives the definition of social and communicative competence and indicators of its forming. Attention is drawn to the fact that the modern army needs officers who would be true professionals in their field, have leadership qualities and be able not only to solve training and combat tasks, but also to navigate the changing social and military reality, to solve complex and multifunctional tasks while performing their professional duties. It is emphasized that an important component of officers’ professionalism is their ability to interact effectively with other individuals in different conditions and situations while performing their professional activities. It is noted that in most cases, the effectiveness of such interaction is associated with military specialist’s communicative skills. These skills reflect their ability to choose, establish and maintain the most appropriate communication style based on respect and personal characteristics of the interlocutor in order to achieve needed professional goals.It is emphasized that in the context of forming future security and defense sector officers’ social and communicative competence, special attention should be paid to the formation of graduate’s neuro-psychological stability, balance and endurance, which, in turn, guarantees a friendly and decent attitude to others. Thus, there is a need for purposeful work with cadets on their communicative skills forming, that is an important component of communicative competence in general.
АНАЛІЗ СУЧАСНИХ ТРАНСФОРМАЦІЙ КОМУНІКАТИВНИХ СТРАТЕГІЙ У ПРОЦЕСІ РОЗВИТКУ КОМУНІКАТИВНОЇ КОМПЕТЕНТНОСТІ ОФІЦЕРІВ-ПРИКОРДОННИКІВ – МАЙБУТНІХ КЕРІВНИКІВ
Authors: ЗАВИДОВИЧ Вікторія
Published: August 2022

У статті зазначено, що вирішальною ланкою в сучасній організації суспільства, його функціонуванні та подальшому прогресивному розвиткові є те, наскільки вміло підібрано керівний склад. Від того, наскільки він компетентний у професійному сенсі, наскільки раціонально реалізується наявний військовий кадровий потенціал, і Держприкордонслужби зокрема, сьогодні залежить успіх і стабільність Української держави.Закцентовано на тому, що сучасні умови в Україні вимагають розвитку нових форм професійної компетентності військових управлінців. Особливого значення в цій діяльності набуває комунікативна складова керівників-офіцерів, що безупинно розвивається та вочевидь стає пріоритетною в управлінських відносинах офіцера-прикордонника.Статтю безпосередньо присвячено такому поняттю, як комунікативна стратегія, що корелює комунікативні дії керівника-прикордонника та сприяє вираженню його інтенцій. Сьогодні силові структури всього світу активно вивчають нові форми стратегій комунікування, такі як сторітелінги, наративи, фреймінги тощо. Установлено, що сторітелінг має вагомі перлокутивні функції, здатні змінити не тільки емоційний стан адресата, а і його свідомість та поведінку. Застосовуючи стратегічні наративи та фреймінги, а також добре орієнтуючись у нових формах і методах комунікативних стратегій, комунікант-керівник матиме значні переваги й більші шанси завоювати аудиторію.Узагальнено, що сучасні трансформації комунікативних стратегій потенційно розширюють можливості викликати в комунікантів довіру й мотивувати їх до певних дій, створювати ефект очікування інформації про унікальний досвід, який легко асоціюється з особистим, дозволяють передавати важливу інформацію як окремому індивіду, так і цілій групі, формувати в уяві адресата чітке розуміння про моральні, духовні цінності, а також що їх вміле застосування дасть можливість вивести комунікативну компетентність майбутнього керівника на новий рівень розвитку, що своєю чергою прямо впливатиме на успішність виконання офіцером-прикордонником керівної ланки професійних функцій і на імідж Держприкордонслужби в цілому.
ПЕРСПЕКТИВИ ПІДГОТОВКИ МОЛОДШИХ СПЕЦІАЛІСТІВ (БАКАЛАВРІВ) ТИЛУ В СИСТЕМІ ДЕРЖАВНОЇ ПРИКОРДОННОЇ СЛУЖБИ УКРАЇНИ
Authors: КРАВЧУК Василь
Published: August 2022

У статті розглядається тилове забезпечення як комплекс заходів, що виступає складовою частиною всебічного забезпечення бойових дій органів (підрозділів) охорони державного кордону Державної прикордонної служби України. Від якісної організації, своєчасного маневру сил і засобів тилового забезпечення залежить результат ведення бойових дій. У роботі проведено аналіз системи тилового забезпечення з урахування досвіду підрозділів Збройних Сил України. Установлено, що значний обсяг завдань із забезпечення ведення бойових дій та оперативно-службової діяльності припадає на молодших спеціалістів підрозділів тилу, а також представників забезпечення відділів прикордонної служби. Серед молодших спеціалістів та працівників тилового спрямування, що потребують навченості та злагодженості, відмічають старшин прикордонних підрозділів; кухарів; водіїв спеціалізованих технічних засобів тилу, діловодів, техніків служб тилу. Установлено, що система професійної підготовки Державної прикордонної служби України не передбачає навченості (бойового злагодження) молодших спеціалістів підрозділів забезпечення. Авторами пропонується створити та впровадити у загальну систему професійної підготовки Державної прикордонної служби України підготовку молодших спеціалістів підрозділів забезпечення. Цю категорію молодших спеціалістів тилу пропонується готувати на базі Головного центру підготовки особового складу Державної прикордонної служби України імені генерал-майора Ігоря Момота (м. Черкаси).Результатами впровадження відповідної підготовки вбачають покращення бойової злагодженості у діях тилових підрозділів, вирішивши питання їх автономності, живучості та стійкості. Упровадження підготовки згуртує колективи, сформує навички польового розгортання прикордонних підрозділів.