bluuebunny/crossref_metadata_2025 huggingface dataset:
Substrate mediated electronic and excitonic reconstruction in a MoS2 monolayer
Authors: Yang Yulin , Song Tingting , Zhang Xiaoman , Zhao Yifei , Chai Jingshan , Cheng Zaijun , Huang Xiaohua , Zhang Hongyi , Zhu Wenzhang , Yang Ming
Published: July 2020

The electronic and optical properties of two-dimensional materials (2D) can be significantly tuned by the presence of substrates.
Oxygen consumption rate of tumour spheroids during necrotic-like core formation
Authors: Mukomoto Rei , Nashimoto Yuji , Terai Takato , Imaizumi Takuto , Hiramoto Kaoru , Ino Kosuke , Yokokawa Ryuji , Miura Takashi , Shiku Hitoshi
Published: July 2020

Scanning electrochemical microscopy (SECM) is a powerful method for evaluating three-dimensional culture models. In this study, we investigated the oxygen consumption rate of tumor spheroids during the formation of necrotic-like core using SECM.
Single-molecule brightness analysis for the determination of anticancer drug interactions with DNA
Authors: Zhou Ying , Bielec Krzysztof , Pasitsuparoad Pakorn , Hołyst Robert
Published: July 2020

We performed brightness analysis at a single molecular level of doxorubicin, daunorubicin, epirubicin, and idarubicin. The method was sensitive enough to confirm that the binding of drugs to the DNA occurs in two reactions.
Visible light mediated PVA-tyramine hydrogels for covalent incorporation and tailorable release of functional growth factors
Authors: Atienza-Roca Pau , Kieser David C. , Cui Xiaolin , Bathish Boushra , Ramaswamy Yogambha , Hooper Gary J. , Clarkson Andrew N. , Rnjak-Kovacina Jelena , Martens Penny J. , Wise Lyn M. , Woodfield Tim B. F. , Lim Khoon S.
Published: July 2020

PVA-Tyr hydrogel facilitated covalent incorporation can control release of pristine growth factors while retaining their native bioactivity.
Catalytic asymmetric aldehyde prenylation and application in the total synthesis of (−)-rosiridol and (−)-bifurcadiol
Authors: Zhang Yu-Long , Zhao Zhen-Ni , Li Wang-Lai , Li Jing-Jie , Kalita Subarna Jyoti , Schneider Uwe , Huang Yi-Yong
Published: July 2020

An asymmetric aldehyde prenylation method assisted by a (R)-BINOL-derived phosphoric acid [(R)-TRIP] catalyst for the total synthesis of (−)-rosiridol and (−)-bifurcadiol has been reported.
A structurally precise AgxAu25−x nanocluster based cancer theranostic platform with tri-targeting/in situ O2-generation/aggregation enhanced fluorescence imaging/photothermal–photodynamic therapies
Authors: Yang Ying , Zhou Yinlong , Wang Shuxin , Wang Xueyan , Liu Xuan , Xie Anjian , Shen Yuhua , Zhu Manzhou
Published: July 2020

Here, a structurally precise AgxAu25−x nanoclusters-based versatile cancer theranostic platform with tri-targeting/aggregation enhanced imaging/phototherapy was constructed.
Synthesis and optical properties of mono- and diaminocorannulenes
Authors: Xie Feifei , Finney Nathaniel S.
Published: July 2020

A simple synthesis of aminocorannulenes leads to the discovery of surprising properties: tunable visible emission; solid-state fluorescence; water-soluble fluorescent corannulenes.
Slow relaxation of the magnetization, reversible solvent exchange and luminescence in 2D anilato-based frameworks
Authors: Benmansour Samia , Hernández-Paredes Antonio , Mondal Arpan , López Martínez Gustavo , Canet-Ferrer Josep , Konar Sanjit , Gómez-García Carlos J.
Published: July 2020

Reversible solvent exchange in three Dy(iii)-bromanilato 2D frameworks with solvent dependent luminescence and slow relaxation of the magnetization.
Natural-abundance 17O NMR spectroscopy of magnetically aligned lipid nanodiscs
Authors: Ravula Thirupathi , Sahoo Bikash R. , Dai Xiaofeng , Ramamoorthy Ayyalusamy
Published: July 2020

Measurement of ordering of water molecules in magnetically aligned polymer-nanodiscs using an integrated 17O NMR and MD simulation.
Full-color natural rubber latex with a photonic nanostructure composite
Authors: Yan Dan , Qiu Lili , Meng Zihui , Shen Yu , Xue Min , Xu Zhibin , Liu Wenfang
Published: July 2020

A full-color natural rubber latex composite dyed by a photonic nanostructure with optical sensing properties for VOCs was designed for the first time.
Coordination polymers as heterogeneous catalysts in hydrogen evolution and oxygen evolution reactions
Authors: Biradha Kumar , Goswami Anindita , Moi Rajib
Published: July 2020

This article highlights various strategies of designing coordination polymers for catalysing water splitting reactions.
Enhancements in the utilization of antigene oligonucleotides in the nucleus by booster oligonucleotides
Authors: Wang Lei , Okamura Hidenori , Sasaki Shigeki , Taniguchi Yosuke
Published: July 2020

Oligonucleotides containing dU, which are called booster oligonucleotides, are excised by uracil-DNA glycosylase in the nucleus and efficiently release complementary strands.
Aggregation induced emission – emissive stannoles in the solid state
Authors: Ramirez y Medina Isabel-Maria , Rohdenburg Markus , Lork Enno , Staubitz Anne
Published: July 2020

For the first time, six classical stannoles with photoluminescence quantum yields of up to 11.1% in the crystalline state and 24.4% in the thin film state are presented.
In situ kinetics studies of Zn–Al LDH intercalation with corrosion related species
Authors: Iuzviuk Mariia H. , Bouali Anissa C. , Serdechnova Maria , Yasakau Kiryl A. , Wieland D. C. Florian , Dovzhenko Gleb , Mikhailau Aliaksandr , Blawert Carsten , Zobkalo Igor A. , Ferreira Mario G. S. , Zheludkevich Mikhail L.
Published: July 2020

The first kinetic study of the anion exchange reactions on LDH conversion layers, with corrosion relevant species.
Octacyanidometallates for multifunctional molecule-based materials
Authors: Chorazy Szymon , Zakrzewski Jakub J. , Magott Michał , Korzeniak Tomasz , Nowicka Beata , Pinkowicz Dawid , Podgajny Robert , Sieklucka Barbara
Published: July 2020

Diverse functional potential of heterometallic systems based on octacyanidometallates places them at the forefront of research into modern molecule-based materials.
Influence of the support on rhodium speciation and catalytic activity of rhodium-based catalysts for total oxidation of methane
Authors: Zhang Yu , Glarborg Peter , Andersson Martin Peter , Johansen Keld , Torp Thomas Klint , Jensen Anker Degn , Christensen Jakob Munkholt
Published: July 2020

In Rh-catalysts for CH4-oxidation, Si-rich zeolite supports yield the more active Rh2O3 nanoparticle form and the highest SO2 and H2O tolerance.
New insights into the stereospecific reduction by an (S) specific carbonyl reductase fromCandida parapsilosisATCC 7330: experimental and QM/MM studies
Authors: Sudhakara Sneha , Ramakrishnan Chandrasekaran , Gromiha M. Michael , Chadha Anju
Published: July 2020

The quantum mechanics/molecular mechanics study of an (S) specific carbonyl reductase fromC. parapsilosisATCC 7330 showing a dual kinetic response for the reduction of ketones and α-ketoesters suggests different reaction mechanisms for the same.
Reaction kinetics and mechanism of CH4-SCR on Ru–In/H-SSZ-13
Authors: Yang Jun , Chang Yupeng , Wu Guangjun , Dai Weili , Guan Naijia , Li Landong
Published: July 2020

The temperature-dependent CH4-SCR mechanism on Ru–In/H-SSZ-13 is elucidated by reaction kinetics and in situ spectroscopy analysis.
Mechanistic studies of in vitro anti-proliferative and anti-inflammatory activities of the Zn(ii)–NSAID complexes of 1,10-phenanthroline-5,6-dione in MDA-MB-231 cells
Authors: Deb Jolly , Lakshman Triloke Ranjan , Ghosh Ivy , Jana Siddhartha Sankar , Paine Tapan Kanti
Published: July 2020

Ternary zinc(ii)–NSAID complexes of 1,10-phenanthroline-5,6-dione have potential as anti-tumor drugs exhibiting anti-inflammatory potential. The complexes cause in vitro delay in cellular migration and down-regulate EMT-related genes.
Mono and dinuclear iridium(iii) complexes featuring bis-tridentate coordination and Schiff-base bridging ligands: the beneficial effect of a second metal ion on luminescence
Authors: Puttock Emma V. , Sil Amit , Yufit Dmitry S. , Williams J. A. Gareth
Published: July 2020

Ditopic bis-N^N^O-coordinating ligands, prepared by Schiff base chemistry, lead to dinuclear iridium complexes that emit much more brightly than their mononuclear counterparts.
Grafting functional groups in metal–organic frameworks for U(vi) sorption from aqueous solutions
Authors: Xiong Jianbo , Fan Yaling , Luo Feng
Published: July 2020

Recent highlights of the organic groups-functionalized MOFs for uranium extraction from aqueous solution are discussed.
Engineering Z-scheme TiO2-OV-BiOCl via oxygen vacancy for enhanced photocatalytic degradation of imidacloprid
Authors: Yang Bin , Zheng Jiliang , Li Wei , Wang Rongjie , Li Danya , Guo Xuhong , Rodriguez Raul D. , Jia Xin
Published: July 2020

A novel Z-scheme TiO2-OV-BiOCl shows better and excellent photocatalytic degradation for imidacloprid than for type-II TiO2/BiOCl.
Solution aggregation of platinum(ii) triimine methyl complexes
Authors: Shingade Vikas M. , Connick William B.
Published: July 2020

Self-assembly processes are investigated in two model compounds, Pt(L)(CH3)+(where, L = 2,6-bis(N-methylbenzimidazol-2-yl)pyridine OR 2,2′;6′2′′-terpyridine), employing NMR. Structural conformations of formed assemblies are confirmed by 2D NOESY.
Molecular layer deposited alucone thin films from long-chain organic precursors: from brittle to ductile mechanical characteristics
Authors: Niemelä Janne-Petteri , Rohbeck Nadia , Michler Johann , Utke Ivo
Published: July 2020

We tailor mechanical properties of molecular-layer-deposited inorganic–organic films through control over the organic precursor length, relevant for battery applications.
Calix[8]arene-constructed stable polyoxo-titanium clusters for efficient CO2 photoreduction
Authors: Li Ning , Liu Jing-Jing , Sun Jia-Wei , Dong Bao-Xia , Dong Long-Zhang , Yao Su-Juan , Xin Zhifeng , Li Shun-Li , Lan Ya-Qian
Published: July 2020

Self-assembly and CO2 photoreduction performance of two thermodynamically reversibly converted polyoxo-titanium clusters (PTCs), Ti4-C8A and Ti7-C8A, which were modified by calix[8]arene organic “functional armor”.
Towards a sustainable generation of pseudopterosin-type bioactives
Authors: Ringel Marion , Reinbold Markus , Hirte Max , Haack Martina , Huber Claudia , Eisenreich Wolfgang , Masri Mahmoud A. , Schenk Gerhard , Guddat Luke W. , Loll Bernhard , Kerr Russell , Garbe Daniel , Brück Thomas
Published: July 2020

Pseudopterosins (Ps), marine diterpene glycosides derived from the marine octocoralAntillogorgia elisabethae, have potent anti-inflammatory activity demonstrated in phase II clinical trials.
Methods to increase sample transport efficiency in single particle inductively coupled plasma mass spectrometry when analyzing nanoparticles
Authors: Williams Andrew , Al Hejami Ahmed , Beauchemin Diane
Published: July 2020

Infrared heating of the sample introduction system increased the transport efficiency, thereby improving the precision of nanoparticle size measurements.
A carbon-coated shuttle-like Fe2O3/Fe1−xS heterostructure derived from metal–organic frameworks with high pseudocapacitance for ultrafast lithium storage
Authors: Zhu Guang , Zhang Xiaojie , Li Yanjiang , Zhao Guangzhen , Xu Haifeng , Jin Zhong
Published: July 2020

A carbon-coated shuttle-like Fe2O3/Fe1−xS heterostructure derived from metal–organic frameworks exhibits ultrafast lithium storage ability owing to high pseudocapacitive contribution.
Synthesis, characterization and formation mechanism of acrylate emulsion-based self-matting coatings
Authors: Meng Yeyun , Yong Qiwen , Liao Bing , Zeng Wei , Pang Hao
Published: July 2020

A green method was employed to obtain a crosslinked self-matting coating, which exhibited a gloss of 5.0 (60°).
Enhanced properties of sulfonated polyether ether ketone proton exchange membrane by incorporating carboxylic-contained zeolitic imidazolate frameworks
Authors: Hu Fuqiang , Wen-Chin Tsen , Zhong Fei , Zhang Bingqing , Wang Jie , Liu Hai , Zheng Genwen , Gong Chunli , Wen Sheng
Published: July 2020

Carboxylic-containing zeolitic imidazolate frameworks (ZIF-COOH) showed an obvious improvement in the performance of sulfonated polyether ether ketone (SPEEK)-based proton exchange membranes.
Delineating the role of crystallinity in the electrocatalytic activity of colloidally synthesized MoP nanocrystals
Authors: Nkabinde Siyabonga S. , Ndala Zakhele B. , Shumbula Ndivhuwo P. , Kolokoto Tshwarela , Nchoe Obakeng , Ngubeni Grace N. , Mubiayi Kalenga P. , Moloto Nosipho
Published: July 2020

The synthesis of non-noble metal nanocrystals as cheaper alternatives to Pt for use as hydrogen evolution reaction (HER) electrocatalysts is highly desired for the future of renewable energy.
Synthesis and reactivity of propionitrilium derivatives of cobalt and iron bis(dicarbollides)
Authors: Bogdanova Ekaterina V. , Stogniy Marina Yu. , Chekulaeva Lyubov A. , Anisimov Aleksei A. , Suponitsky Kyrill Yu. , Sivaev Igor B. , Grin Mikhail A. , Mironov Andrey F. , Bregadze Vladimir I.
Published: July 2020

The nucleophilic addition of alcohols and thiols to 8-propionitrilium derivatives of cobalt and iron bis(dicarbollides) gives the corresponding imidates and thioimidates.
CO direct esterification to dimethyl oxalate and dimethyl carbonate: the key functional motifs for catalytic selectivity
Authors: Wang Zhi-Qiao , Sun Jing , Xu Zhong-Ning , Guo Guo-Cong
Published: July 2020

The key functional motifs for the selectivity have been discussed in detail in this review. The isolated Pd is conducive for dimethyl carbonate (DMC), while the aggregated Pd is beneficial for dimethyl oxalate (DMO).
Tuning properties of silver nanoclusters with RNA nanoring assemblies
Authors: Yourston Liam , Rolband Lewis , West Caroline , Lushnikov Alexander , Afonin Kirill A. , Krasnoslobodtsev Alexey V.
Published: July 2020

Combining atomically resolved DNA-templated silver nanoclusters (AgNCs) with nucleic acid nanotechnology opens new exciting possibilities for engineering bioinorganic nanomaterials with uniquely tunable properties.
Modification of composite catalytic material CumVnOx@CeO2 core–shell nanorods with tungsten for NH3-SCR
Authors: Huang Xiaosheng , Dong Fang , Zhang Guodong , Tang Zhicheng
Published: July 2020

Tungsten anchoring Cu3(VO4)2@CeO2 nanorods with a core–shell structure exhibited satisfactory NH3-SCR catalytic performance.
Transition-metal-catalyzed C–H functionalization of pyrazoles
Authors: Kang Eunsu , Kim Hyun Tae , Joo Jung Min
Published: July 2020

This review describes recent advances in transition-metal-catalyzed C–H functionalization reactions of pyrazoles to form new C–C and C–heteroatom bonds on the pyrazole ring.
Light-triggered disassembly of photo-responsive gold nanovesicles for controlled drug release
Authors: Tan Haiying , Liu Yuanyuan , Xie Jun , Gao Yujie , Li Yuce , Ma Li , Zhang Lianbin , Tang Tao , Zhu Jintao
Published: July 2020

Light-triggered disassembly of gold nanovesicles (GVs) from amphiphilic photo-responsive block copolymer tethered gold nanoparticles can be used for controlled drug release. And after the release of the loaded drugs, the GVs still exhibited photothermal properties which might be used for combined therapy.
Sequential sequestrations increase the incorporation and retention of multiple growth factors in mineralized collagen scaffolds
Authors: Tiffany Aleczandria S. , Dewey Marley J. , Harley Brendan A. C.
Published: July 2020

Trauma induced injuries of the mouth, jaw, face, and related structures present unique clinical challenges due to their large size and complex geometry.
Cell-free biology using remote-controlled digital microfluidics for individual droplet control
Authors: Liu Dong , Yang Zhenghuan , Zhang Luyang , Wei Minglun , Lu Yuan
Published: July 2020

Cell-free biology using remote-controlled digital microfluidics for programmed biological screening and synthesis.
The crystal engineering of radiation-sensitive diacetylene cocrystals and salts
Authors: Hall Amy V. , Yufit Dmitry S. , Apperley David C. , Senak Larry , Musa Osama M. , Hood David K. , Steed Jonathan W.
Published: July 2020

In this work we develop photoreactive cocrystals/salts of a commercially-important diacetylene, 10,12-pentacosadiynoic acid (PCDA, 1) and report the first X-ray crystal structures of PCDA based systems.
An atropisomeric M2L4cage mixture displaying guest-induced convergence and strong guest emission in water
Authors: Tsutsui Takahiro , Catti Lorenzo , Yoza Kenji , Yoshizawa Michito
Published: July 2020

A complex mixture of atropisomeric M2L4cages is shown to undergo perfect convergence to a single isomer upon encapsulation of spherical C60in water. Moreover, the cage mixture displays very strong guest emission upon encapsulation of a BODIPY dye.
Topological defects due to twist-bend nematic drops mimicking colloidal particles in a nematic medium
Authors: Krishnamurthy K. S. , Rao D. S. Shankar , Kanakala Madhu B. , Yelamaggad Channabasaveshwar V. , Kleman Maurice
Published: July 2020

Two opposite topological dipoles, each formed of a large twist-bend nematic drop (+1) and a satellite nematic drop (−1).
Gradient band structure: high performance perovskite solar cells using poly(bisphenol A anhydride-co-1,3-phenylenediamine)
Authors: Kanda Hiroyuki , Shibayama Naoyuki , Abuhelaiqa Mousa , Paek Sanghyun , Kaneko Ryuji , Klipfel Nadja , Sutanto Albertus Adrian , Carmona Cristina Roldán , Huckaba Aron Joel , Kim Hobeom , Momblona Cristina , Asiri Abdullah M. , Nazeeruddin Mohammad Khaja
Published: July 2020

A non-reactive material generates beneficial band-bending resulting in higher photovoltaic performance and also stability by suppressing Pb0 at the perovskite surface.
Photo-triggered release of doxorubicin from liposomes formulated by amphiphilic phthalocyanines for combination therapy to enhance antitumor efficacy
Authors: Zheng Ke , Liu Hongyan , Liu Xinxin , Jiang Libin , Li Linlin , Wu Xianggen , Guo Nannan , Ding Caifeng , Huang Mingdong
Published: July 2020

Multidrug combination therapy based on stimuli-responsive liposomes formulated by amphiphilic phthalocyanines has great potential for cancer treatment.
Manipulation of the sterically hindering effect to realize AIE and TADF for high-performing nondoped solution-processed OLEDs with extremely low efficiency roll-off
Authors: Sun Kaiyong , Liu Dan , Tian Wenwen , Gu Feng , Wang Wangxia , Cai Zhaosheng , Jiang Wei , Sun Yueming
Published: July 2020

Through alleviating the sterically hindered effect of donor units by inserting the Ph-bridge, a robust luminogen with TADF and AIE nature is achieved for high-performing nondoped solution-processed OLEDs with extremely low efficiency roll-off.
Organophosphate hydrolase interacts with ferric-enterobactin and promotes iron uptake in association with TonB-dependent transport system
Authors: Parapatla Hari , Gudla Ramurthy , Konduru Guruprasad Varma , Devadasu Elsin Raju , Nagarajaram Hampapathula Adimurthy , Sritharan Manjula , Subramanyam Rajagopal , Siddavattam Dayananda
Published: July 2020

Our previous studies have shown the existence of organophosphate hydrolase (OPH) as a part of the inner membrane associated Ton complex (ExbB/ExbD and TonB) of Sphingobium fuliginis. We now show its involvement in iron uptake by establishing direct interactions with ferric-enterobactin. The interactions between OPH and ferric-enterobactin were not affected even when the active site architecture is altered by substituting active site aspartate with either alanine or asparagine. Protein docking studies further substantiated these findings and predicted the existence of ferric-enterobactin binding site that is different from the catalytic site of OPH. A lysine residue (82K) found at the predicted ferric-enterobactin binding site facilitated interactions between OPH and ferric-enterobactin. Substitution of lysine with alanine did not affect triesterase activity, but it abrogated OPH ability to interact with both ferric-enterobactin and ExbD, strengthening further the fact that the catalytic site is not the site for binding of these ligands. In the absence of interactions between OPHK82A and ExbD, OPHK82A failed to target membrane in E. coli cells. The Sphingobium fuliginis TonB-dependent transport (SfTonBDT) system was reconstituted in E. coli GS027 cells generated by deleting the exbD and tonB genes. The E. coli GS030 cells having SfTonBDT system with OPH showed increased iron uptake. Such an increase was not seen in E. coli GS029, cells having SfTonBDT system generated either by omitting OPH or by including its variants, OPHD301A, OPHD301N suggesting a role for OPH in enhanced iron uptake.
Establishment and characterization of Neu1-knockout zebrafish and its abnormal clinical phenotypes
Authors: Okada Keiji , Takase Ryo , Hamaoka Yurie , Honda Akinobu , Ikeda Asami , Hokazono Yoichiro , Maeda Yutaro , Hayasaka Oki , Kotani Tomonari , Komatsu Masaharu , Shiozaki Kazuhiro
Published: July 2020

Mammalian sialidase Neu1 is involved in various physiological functions, including cell adhesion, differentiation, cancer metastasis, and diabetes through lysosomal catabolism and desialylation of glycoproteins at the plasma membrane. Various animal models have been established to further explore the functions of vertebrate Neu1. The present study focused on zebrafish (Danio rerio) belonging to Cypriniformes as an experimental animal model with neu1 gene deficiency. The results revealed that the zebrafish Neu1 desialyzed both α2–3 and α2–6 sialic acid linkages from oligosaccharides and glycoproteins at pH 4.5, and it is highly conserved with other fish species and mammalian Neu1. Furthermore, Neu1-knockout zebrafish (Neu1-KO) was established through CRISPR/Cas9 genome editing. Neu1-KO fish exhibited slight abnormal embryogenesis with the accumulation of pleural effusion; however, no embryonic lethality was observed. Although Neu1-KO fish were able to be maintained as homozygous, they showed smaller body length and weight than the wild-type (WT) fish, and muscle atrophy and curvature of the vertebra were observed in adult Neu1-KO fish (8 months). The expression patterns of myod and myog transcription factors regulating muscle differentiation varied between Neu1-KO and WT fish embryo. Expression of lysosomal-related genes, including ctsa, lamp1a, and tfeb were up-regulated in adult Neu1-KO muscle as compared with WT. Furthermore, the expression pattern of genes involved in bone remodeling (runx2a, runx2b, and mmp9) was decreased in Neu1-KO fish. These phenotypes were quite similar to those of Neu1-KO mice and human sialidosis patients, indicating the effectiveness of the established Neu1-KO zebrafish for the study of vertebrate Neu1 sialidase.
Promutagenic bypass of 7,8-dihydro-8-oxoadenine by translesion synthesis DNA polymerase Dpo4
Authors: Jung Hunmin , Lee Seongmin
Published: July 2020

Reactive oxygen species induced by ionizing radiation and metabolic pathways generate 7,8-dihydro-8-oxoguanine (oxoG) and 7,8-dihydro-8-oxoadenine (oxoA) as two major forms of oxidative damage. The mutagenicity of oxoG, which promotes G to T transversions, is attributed to the lesion's conformational flexibility that enables Hoogsteen base pairing with dATP in the confines of DNA polymerases. The mutagenesis mechanism of oxoA, which preferentially causes A to C transversions, remains poorly characterized. While structures for oxoA bypass by human DNA polymerases are available, that of prokaryotic DNA polymerases have not been reported. Herein, we report kinetic and structural characterizations of Sulfolobus solfataricus Dpo4 incorporating a nucleotide opposite oxoA. Our kinetic studies show oxoA at the templating position reduces the replication fidelity by ∼560-fold. The catalytic efficiency of the oxoA:dGTP insertion is ∼300-fold greater than that of the dA:dGTP insertion, highlighting the promutagenic nature of oxoA. The relative efficiency of the oxoA:dGTP misincorporation is ∼5-fold greater than that of the oxoG:dATP misincorporation, suggesting the mutagenicity of oxoA is comparable to that of oxoG. In the Dpo4 replicating base pair site, oxoA in the anti-conformation forms a Watson–Crick base pair with an incoming dTTP, while oxoA in the syn-conformation assumes Hoogsteen base pairing with an incoming dGTP, displaying the dual coding potential of the lesion. Within the Dpo4 active site, the oxoA:dGTP base pair adopts a Watson–Crick-like geometry, indicating Dpo4 influences the oxoA:dGTP base pair conformation. Overall, the results reported here provide insights into the miscoding properties of the major oxidative adenine lesion during translesion synthesis.
Pinocembrin alleviates ulcerative colitis in mice via regulating gut microbiota, suppressing TLR4/MD2/NF-κB pathway and promoting intestinal barrier
Authors: Yue Bei , Ren Junyu , Yu Zhilun , Luo Xiaoping , Ren Yijing , Zhang Jing , Mani Sridhar , Wang Zhengtao , Dou Wei
Published: July 2020

Pinocembrin, a plant-derived flavonoid, has a variety of pharmacological activities, including anti-infection, anti-cancer, anti-inflammation, cardiovascular protection, etc. However, the mechanism of pinocembrin on the anti-colitis efficacy remains elusive and needs further investigation. Here, we reported that pinocembrin eased the severity of dextran sulfate sodium (DSS)-induced colitis in mice by suppressing the abnormal activation of toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) signal pathway in vivo. In addition, the gut microbiota was disordered in DSS colitis mice, which was associated with a significant decrease in microbiota diversity and a great shift in bacteria profiles; however, pinocembrin treatment improved the imbalance of gut microbiota and made it similar to that in normal mice. On the other hand, in vitro, pinocembrin down-regulated the TLR4/NF-κB signaling cascades in lipopolysaccharide (LPS)-stimulated macrophages. At the upstream level, pinocembrin competitively inhibited the binding of LPS to myeloid differentiation protein 2 (MD2), thereby blocking the formation of receptor multimer TLR4/MD2·LPS. Furthermore, pinocembrin dose-dependently promoted the expression of tight junction proteins (ZO-1, Claudin-1, Occludin and JAM-A) in Caco-2 cells. In conclusion, our work presented evidence that pinocembrin attenuated DSS-induced colitis in mouse, at least in part, via regulating intestinal microbiota, inhibiting the over-activation of TLR4/MD2/NF-κB signaling pathway, and improving the barriers of intestine.
Stripped-envelope core-collapse supernova 56Ni masses
Authors: Meza N. , Anderson J. P.
Published: July 2020

Context. The mass of synthesised radioactive material is an important power source for all supernova (SN) types. In addition, the difference of 56Ni yields statistics are relevant to constrain progenitor paths and explosion mechanisms.

Aims. Here, we re-estimate the nucleosynthetic yields of 56Ni for a well-observed and well-defined sample of stripped-envelope SNe (SE-SNe) in a uniform manner. This allows us to investigate whether the observed hydrogen-rich–stripped-envelope (SN II–SE SN) 56Ni separation is due to real differences between these SN types or because of systematic errors in the estimation methods.

Methods. We compiled a sample of well-observed SE-SNe and measured 56Ni masses through three different methods proposed in the literature: first, the classic “Arnett rule”; second the more recent prescription of Khatami & Kasen (2019, ApJ, 878, 56) and third using the tail luminostiy to provide lower limit 56Ni masses. These SE-SN distributions were then compared to those compiled in this article.

Results. Arnett’s rule, as previously shown, gives 56Ni masses for SE-SNe that are considerably higher than SNe II. While for the distributions calculated using both the Khatami & Kasen (2019, ApJ, 878, 56) prescription and Tail 56Ni masses are offset to lower values than “Arnett values”, their 56Ni distributions are still statistically higher than that of SNe II. Our results are strongly driven by a lack of SE-SN with low 56Ni masses, that are, in addition, strictly lower limits. The lowest SE-SN 56Ni mass in our sample is of 0.015 M⊙, below which are more than 25% of SNe II.

Conclusions. We conclude that there exist real, intrinsic differences in the mass of synthesised radioactive material between SNe II and SE-SNe (types IIb, Ib, and Ic). Any proposed current or future CC SN progenitor scenario and explosion mechanism must be able to explain why and how such differences arise or outline a bias in current SN samples yet to be fully explored.
The orbit of Triton with new precise observations and the INPOP19a ephemeris
Authors: Tang K. , Song Y. Z. , Shen K. X. , Qiao R. C. , Tang Z. H. , Yu Y. , Zhang H. Y. , Yan D.
Published: July 2020

Aims. The Gaia catalogue brings new opportunities and challenges to high-precision astronomy and astrometry. The precision of data reduction is therefore improved by a large number of reference stars with high-precision positions and proper motions. Numerous precise positions for Triton are obtained from the latest observations using the Gaia catalogue. Furthermore, the new INPOP19a planetary ephemeris, which also fits the observations from the Gaia Data Release 2, has recently become available. In this paper, a new orbit of Triton is calculated using the latest precise charge-coupled device (CCD) observations and the INPOP19a ephemeris.

Methods. Triton’s orbital solution is calculated using a numerical integrator, while the orientation of Neptune’s pole in particular is obtained by integrating the simplified Euler’s equations of motion. We determine the orbit of Triton over 170 yr based on 11 040 Earth-based observations made between 1847 and 2016 and on Voyager 2 data. The positions of the Sun and planets are provided by the INPOP19a ephemeris. We compare our results to those from other previous works to check the influences on Triton’s orbit from different planetary ephemerides.

Results. A new orbit of Triton is provided here. The root-mean-square of the residuals for the Earth-based CCD absolute observations are 0.102″ in right ascension and 0.142″ in declination. Although most different planetary ephemerides have large differences in Neptune’s position, the orbits of Triton using different planetary ephemerides are still close, under similar dynamical models. The Voyager 2 data add a constraint on Triton’s orbit here.
GALACTICNUCLEUS: A high angular-resolution JHKs imaging survey of the Galactic centre
Authors: Nogueras-Lara F. , Schödel R. , Neumayer N. , Gallego-Cano E. , Shahzamanian B. , Gallego-Calvente A. T. , Najarro F.
Published: July 2020

Context. The characterisation of the extinction curve in the near-infrared (NIR) is fundamental to analysing the structure and stellar population of the Galactic centre (GC), whose analysis is hampered by the extreme interstellar extinction (AV ~ 30 mag) that varies on arc-second scales. Recent studies indicate that the behaviour of the extinction curve might be more complex than previously assumed, pointing towards a variation of the extinction curve as a function of wavelength.

Aims. We aim to analyse the variations of the extinction index, α, with wavelength, line-of-sight, and absolute extinction, extending previous analyses to a larger area of the innermost regions of the Galaxy.

Methods. We analysed the whole GALACTICNUCLEUS survey, a high-angular resolution (~0.2″) JHKs NIR survey specially designed to observe the GC in unprecedented detail. It covers a region of ~6000 pc2, comprising fields in the nuclear stellar disc, the inner bulge, and the transition region between them. We applied two independent methods based on red clump (RC) stars to constrain the extinction curve and analysed its variation superseding previous studies.

Results. We used more than 165 000 RC stars and increased the size of the regions analysed significantly to confirm that the extinction curve varies with the wavelength. We estimated a difference Δα = 0.21 ± 0.07 between the obtained extinction indices, αJH = 2.44 ± 0.05 and αHKs = 2.23 ± 0.05. We also concluded that there is no significant variation of the extinction curve with wavelength, with the line-of-sight or the absolute extinction. Finally, we computed the ratios between extinctions, AJ∕AH = 1.87 ± 0.03 and AH/AKs = 1.84 ± 0.03, consistent with all the regions of the GALACTICNUCLEUS catalogue.
Massive molecular gas reservoir around the central AGN in the CARLA J1103 + 3449 cluster at z = 1.44
Authors: Markov Vladan , Mei Simona , Salomé Philippe , Combes Françoise , Stern Daniel , Galametz Audrey , De Breuck Carlos , Wylezalek Dominika , Amodeo Stefania , Cooke Elizabeth A. , Gonzalez Anthony H. , Hatch Nina A. , Noirot Gaël , Rettura Alessandro , Seymour Nick , Stanford Spencer A. , Vernet Joël
Published: July 2020

Passive early-type galaxies dominate cluster cores at z ≲ 1.5. At higher redshift, cluster core galaxies are observed to have on-going star-formation, which is fueled by cold molecular gas. We measured the molecular gas reservoir of the central region around the radio-loud active galactic nucleus (AGN) in the cluster CARLA J1103 + 3449 at z = 1.44 using NOEMA. The AGN synchrotron emission dominates the continuum emission at 94.48 GHz, and we measured its flux at the AGN position and at the position of two radio jets. Combining our measurements with published results over the range 4.71–94.5 GHz, and assuming Ssynch ∝ ν−α, we obtain a flat spectral index of α = 0.14 ± 0.03 for the AGN core emission, and a steeper index of α = 1.43 ± 0.04 and α = 1.15 ± 0.04 at positions close to the western and eastern lobes, respectively. The total spectral index is α = 0.92 ± 0.02 over the range 73.8 MHz–94.5 GHz. We detect two CO(2–1) emission lines, both blueshifted with respect to the AGN. Their emission corresponds to two regions, ~17 kpc southeast and ~14 kpc southwest of the AGN, not associated with galaxies. In these two regions, we find a total massive molecular gas reservoir of Mgastot = 3.9 ± 0.4 × 1010 M⊙, which dominates (≳60%) the central total molecular gas reservoir. These results can be explained by massive cool gas flows in the center of the cluster. The AGN early-type host is not yet quenched; its star formation rate is consistent with being on the main sequence of star-forming galaxies in the field (star formation rate ~30–140 M⊙ yr−1), and the cluster core molecular gas reservoir is expected to feed the AGN and the host star formation before quiescence. The other confirmed cluster members show star formation rates at ~2σ below the field main sequence at similar redshifts and do not have molecular gas masses larger than galaxies of similar stellar mass in the field.
Cyclically monotone non-optimal N-marginal transport plans and Smirnov-type decompositions for N-flows
Authors: Petrache Mircea
Published: July 2020

In the setting of optimal transport with N ≥ 2 marginals, a necessary condition for transport plans to be optimal is that they are c-cyclically monotone. For N = 2 there exist several proofs that in very general settings c-cyclical monotonicity is also sufficient for optimality, while for N ≥ 3 this is only known under strong conditions on c. Here we give a counterexample which shows that c-cylclical monotonicity is in general not sufficient for optimality if N ≥ 3. Comparison with the N = 2 case shows how the main proof strategies valid for the case N = 2 might fail for N ≥ 3. We leave open the question of what is the optimal condition on c under which c-cyclical monotonicity is sufficient for optimality. The new concept of an N-flow seems to be helpful for understanding the counterexample: our construction is based on the absence of finite-support closed N-flows in the set where our counterexample cost c is finite. To follow this idea we formulate a Smirnov-type decomposition for N-flows.
Longitudinal distribution of macroinvertebrate in a very wet North African Basin: Oued Melloulou (Morocco)
Authors: Taybi Abdelkhaleq Fouzi , Mabrouki Youness , Dakki Mohamed , Berrahou Ali , Millán Andrés
Published: July 2020

Melloulou River, which is located in Middle Atlas of Morocco, is a good example of a very wet and poorly known basin, and therefore of special conservation concern. The aim of this study was to draw up an initial inventory of the benthic macroinvertebrates taxa, and to analyze its longitudinal distribution in the basin, particularly searching for the main abiotic factors addressing its zonation for improving future management and conservation actions. The study allowed identifying 161 taxa belonging to 127 genera and 80 families, most new records for northeast Morocco. The biotypology, which was studied by using Foucart' Factorial Correspondence Analysis (FCA), Partial Triadic analysis (PTA), and IndVal showed a longitudinal distribution of macroinvertebrates mainly governed by altitude, slope and current velocity. The studied biota revealed the presence of three assemblages and an important number of ubiquitous species not included in any group. The first group is located in the upper courses of Melloulou River representing a community proper of a crenon-rhithron zone; the second occurs in the middle and lower courses, and clearly reflects the community of a large potamon; the third one is a mixture of taxa capable to colonize the entire study area. Our finding, highlight the singular aquatic biodiversity occurring in the Melloulou River and its extraordinary changing water dynamic over time, which are key factors for future monitoring, as well as managing and conservation actions.
Convergence of an implicit scheme for diagonal non-conservative hyperbolic systems
Authors: Boudjerada Rachida , El Hajj Ahmad , Oussaily Aya
Published: July 2020

In this paper, we consider diagonal non-conservative hyperbolic systems in one space dimension with monotone and large Lipschitz continuous data. Under a certain nonnegativity condition on the Jacobian matrix of the velocity of the system, global existence and uniqueness results of a Lipschitz solution for this system, which is not necessarily strictly hyperbolic, was proved in El Hajj and Monneau (J. Hyperbolic Differ. Equ.10(2013) 461–494). We propose a natural implicit scheme satisfiying a similar Lipschitz estimate at the discrete level. This property allows us to prove the convergence of the scheme without assuming it strictly hyperbolic.
Molecular identification of trypanosomes in cattle in Malawi using PCR methods and nanopore sequencing: epidemiological implications for the control of human and animal trypanosomiases
Authors: Marsela Megasari , Hayashida Kyoko , Nakao Ryo , Chatanga Elisha , Gaithuma Alex Kiarie , Naoko Kawai , Musaya Janelisa , Sugimoto Chihiro , Yamagishi Junya
Published: July 2020

This study aimed to identify trypanosomes infecting cattle in Malawi in order to understand the importance of cattle in the transmission dynamics of Human African Trypanosomiasis (HAT) and Animal African Trypanosomosis (AAT). A total of 446 DNA samples from cattle blood from three regions of Malawi were screened for African trypanosomes by ITS1 PCR. The obtained amplicons were sequenced using a portable next-generation sequencer, MinION, for validation. Comparison of the results from ITS1 PCR and MinION sequencing showed that combining the two methods provided more accurate species identification than ITS1 PCR alone. Further PCR screening targeting the serum resistance-associated (SRA) gene was conducted to detect Trypanosoma brucei rhodesiense. Trypanosoma congolense was the most prevalent Trypanosoma sp., which was found in Nkhotakota (10.8%; 20 of 185), followed by Kasungu (2.5%; 5 of 199). Of note, the prevalence of T. b. rhodesiense detected by SRA PCR was high in Kasungu and Nkhotakota showing 9.5% (19 of 199) and 2.7% (5 of 185), respectively. We report the presence of animal African trypanosomes and T. b. rhodesiense from cattle at the human–livestock–wildlife interface for the first time in Malawi. Our results confirmed that animal trypanosomes are important causes of anemia in cattle and that cattle are potential reservoirs for human African trypanosomiasis in Malawi.
Polytrauma nach Motorradunfall
Authors: Siegemund Kerstin I.
Published: July 2020

Herr P. erlitt durch einen Motorradunfall multiple Traumata mit Verbrennungen von 27 % der Körperoberfläche. Seine Ergotherapeutin beschreibt die folgende, neunmonatige Rehabilitation der oberen Extremitäten von Intensivstation bis zum Erreichen der ambulanten Therapie. Sie zeigt dabei auf, welche Behandlungsmaßnahmen in den verschiedenen Phasen dazu beitrugen, dass Herr P. seine Handlungsfähigkeit im Alltag wiedererlangte.
Landing Evaluation in Soccer Players with or without Anterior Cruciate Ligament Reconstruction
Authors: Alanazi Ahmad , Mitchell Katy , Roddey Toni , Alenazi Aqeel , Alzhrani Msaad , Ortiz Alexis
Published: July 2020

The purpose of this study was to evaluate landing biomechanics in soccer players following
ACLR during two landing tasks. Eighteen soccer players with an ACLR and 18 sex-matched healthy
control soccer players participated in the study. Planned landing included jumping forward and
landing on the force-plates, whereas unplanned landing included jumping forward to head a
soccer ball and landing on the force-plates. A significant landing×group interaction
was found only for knee flexion angles (p=0.002). Follow-up comparisons showed that
the ACL group landed with greater knee flexion during planned landing compared with unplanned
landing (p<0.001). Significant main effects of landing were found. The unplanned
landing showed reduction in hip flexion (p<0.001), hip extension moments
(p<0.013), knee extension moments (p<0.001), and peak pressure
(p<0.001). A significant main effect for group for gastrocnemius muscle was found
showing that the ACL group landed with reduced gastrocnemius activity (p=0.002).
Unplanned landing showed greater injury predisposing factors compared with planned landing.
The ACL group showed nearly similar landing biomechanics to the control group during both
landing tasks. However, the ACL group used a protective landing strategy by reducing
gastrocnemius activity.
Characteristics of Osteochondral Lesions of the Talus in Different Age Groups
Authors: Cao Yongxing , Xu Yang , Huang Qiang , Hong Yuan , Xu Xiangyang
Published: July 2020

We analyzed the characteristics of 112 consecutive patients who were operatively
treated for osteochondral lesions of the talus from August 2014 to April 2019 in
our hospital. The patients were divided into three age groups: young-adult
(<40 years), middle-age (40–60 years) and old-age (>60
years). The basic clinical features, localization and size of the lesions,
Hepple stage, and surgical procedures were compared among groups. Several
significant differences were found on the characteristics of osteochondral
lesions of the talus among age groups. There were more female patients in the
old-age group (p<0.01), and old patients had a longer duration of
symptoms (p<0.05). The OLTs in middle- and old-age patients were mostly
located in the medial part of the talus with larger depth (p<0.01).
Hepple stage 5, the cystic type, was very common in the old-age group
(p<0.01). With regard to surgical procedures, more osteochondral
autograft transplantations were applied in the old-age group (p<0.01).
Female and deep medial talar subchondral cyst is the typical characteristics of
patients over 60 years old. Age is an important factor that must be considered
when choosing surgery procedure for patients with osteochondral lesions of the
talus.
Effects of Three Resistance Exercise Orders on Muscular Function and Body Composition in Older Women
Authors: Dib Márcia M. , Tomeleri Crisieli M. , Nunes João Pedro , Cunha Paolo M. , Ribeiro Alex S. , Schiavoni Durcelina , Cavalcante Edilaine F. , Kunevaliki Gabriel , Teixeira Denilson C. , de Oliveira Arli R. , Gonçalves Ezequiel M. , Gobbo Luís A. , Silva Analiza M. , Sardinha Luís B. , Cyrino Edilson S.
Published: July 2020

The purpose of the present study was to compare the effects of three resistance exercise orders on muscular strength, body composition, and functional fitness in trained older women. Forty-five women (aged ≥60 years), after performing 12 weeks of a pre-conditioning resistance-training program were randomly assigned in one of the following groups that performed the exercises in the following orders: multi-joint to single-joint order (MJ-SJ, n=15), single-joint to multi-joint order (SJ-MJ, n=15), and alternating between upper and lower body order (ALT, n=15). Specific training intervention lasted 12 weeks (3x/week) and was composed of eight exercises performed in three sets of 15/10/5 repetitions, with increasing load through the sets. Muscular strength was estimated by one-repetition maximum tests; body composition was assessed by whole-body dual-energy x-ray absorptiometry, and functional fitness was analyzed with a sequence of four motor tests. All groups improved similarly in muscular strength (Cohen’s effect size: MJ-SJ=0.45; SJ-MJ=0.48; ALT=0.45), skeletal muscle mass (MJ-SJ=0.08; SJ-MJ=0.07; ALT=0.09), and functional test performance (MJ-SJ=0.38; SJ-MJ=0.20; ALT=0.31), but no change was observed for body fat (P>0.05). The results suggest that 12 weeks of resistance training induce positive changes in muscle morphofunctionality, regardless of the exercise order employed in trained older women.
Females Sustain more Ankle Injuries than Males in Youth
Football
Authors: Sokka Taru , Hilska Matias , Vasankari Tommi , Leppänen Mari , Kannus Pekka , Parkkari Jari , Haapasalo Heidi , Forsman Hannele , Raitanen Jani , Pasanen Kati
Published: July 2020

This prospective study evaluated the incidence and pattern of acute injuries in
youth (9- to 14-year- old) football players. Ten football clubs [n=730
players (567 males, 163 females)] participated in the 20-week follow-up study
(January–June 2015). Data was collected by sending a standardized weekly
SMS to players’ parents/guardians with follow-up interviews for
injured players. During the study period, 278 players (38%) sustained
410 acute injuries. The overall injury incidence for males and females was 6.47
(95% CI, 5.84–7.09) injuries per 1000 h of football
exposure. Most injuries (40%) caused minimal absence from sports.
Eighty-four percent of the injuries affected the lower extremities, with the
ankle (30%), knee (17%), and thigh (16%) being the most
commonly injured body sites. Females had significantly higher ankle injury rate
(IRR) 1.85 (95% CI, 1.18–2.91, p=0.007) and non-contact
ankle injury rate IRR 2.78 (95% CI, 1.91–4.02, p<0.001)
than males. In conclusion, our results showed that the acute injury incidence
among youth football is moderately high, and females are at higher risk for
ankle injuries. Injury prevention programs aimed at preventing ankle injuries
should be considered in the future.
Stellenwert der intraoperativen optischen Kohärenztomografie in der Netzhautchirurgie. Teil 1: pro
Authors: Hattenbach Lars-Olof
Published: July 2020

Die intraoperative optische Kohärenztomografie (iOCT) der neuesten Generation bietet durch vollständige Integration der SD-OCT in das OP-Mikroskop erstmals die Möglichkeit einer gezielten hochauflösenden Bildgebung in Echtzeit. Im Vergleich zur konventionellen OP-Mikroskopie wird so eine direkte Befundkontrolle möglich, die für intraoperative Entscheidungen genutzt werden kann. Darüber hinaus gestattet die direkte Einblendung des Live-OCT in das Okular des Mikroskops eine gleichzeitige Darstellung sowohl der mikroskopischen Ansicht als auch der Schichtdarstellung retinaler Mikrostrukturen und damit die präzise Steuerung chirurgischer Manöver. Im Resultat erhält der operative Anwender eine völlig neue Dimension kontrollierter Vitreoretinalchirurgie im Mikrometerbereich.