bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid production of abundant transgenic pomegranate (Punica granatum) hairy roots
Authors: Singh Sailendra , Yaritz Uri , Ramer Nadav , Holland Doron , Amir Rachel , Tian Li
Published: May 2024

Pomegranates (Punica granatum) are known for their high levels of health-beneficial compounds that belong to the hydrolyzable tannin (HT) and flavonoid families. However, a significant gap in our understanding exists of the biosynthetic and regulatory genes related to the accumulation of these compounds. To this end, the induction and transformation of hairy roots presents an exciting opportunity to decipher genetically the functions of candidate genes involved in the HT and flavonoid metabolism. This study aims at improving methods for rapid and abundant hairy root production from pomegranate explants by increasing seed germination rates and expediting the attainment of requisite biomass for multifaceted analyses. We found that treating seeds with sandpaper and concentrated sulfuric acid significantly enhanced their germination rates. Interestingly, no correlation between seed-coat texture and seed germination rate was observed among the 20 pomegranate accessions evaluated in this study. Notably, transferring hairy roots from agar plates to soil promoted rapid root biomass growth compared to maintaining them on agar plates. Root biomass as well as levels of gallic acid (a precursor for HT biosynthesis) and punicalagins (the major HTs in roots) across 15 pomegranate accessions were also analyzed. Three of these accessions exhibited higher seed germination percentages along with augmented biomass and elevated punicalagin levels. These pomegranate accessions emerge as promising germplasm for future genetic transformation and functional genomics studies.
Demonstration and Analysis of Conditions to Obtain a High Strength Inconel 625 to Stainless Steel 304L Interface by Directed Energy Deposition
Authors: Stair A. J. , Webler Bryan A. , Beuth Jack L. , de Boer Maarten P.
Published: May 2024

Functional grading (FG) is often used to bond dissimilar metals. However, that approach is complicated from a manufacturing perspective, and the associated challenges can outweigh the benefits of FG. Here, we investigate a directly bonded interface by transitioning from stainless steel 304L (SS304L) to Inconel 625 (IN625) using powder-feed directed energy deposition with a laser beam energy source (DED-LB). Both cracking and the presence of carbide phases have been reported in this multi-materials system. Conditions that unambiguously achieve crack-free joints have not yet been established. With DED-LB, we consistently observe solidification cracking in melt pools containing > 50 wt pct SS304L, while no cracking is observed in melt pools with < 40 wt pct SS304L. Variations on the most up-to-date solidification cracking model are applied to gain insight into the cracking dependencies. Parameters that give rise to defect-free single layers also enable defect-free multilayer prints despite the additional thermal cycling. Upon printing and testing full-sized ASTM E8 tensile specimens, the interface is sufficiently strong that failure occurs solely within the SS304L region, indicating a joint strength of > 650 MPa. Thus, a simple method to attain high strength joints for these dissimilar metal alloys is demonstrated.
Concentration-Dependent Effects of Boric Acid on Osteogenic Differentiation of Vascular Smooth Muscle Cells
Authors: Al Khalif Osama , Sezer Gülay
Published: May 2024

Vascular calcification can be triggered by oxidative stress and inflammation. Although boron possesses antioxidant and anti-inflammatory properties, its effect on osteogenic differentiation of vascular smooth muscle cells (VSMCs) has yet to be examined. Therefore, we aimed to investigate the effect of boric acid (BA), the main form of boron in body fluids, on the osteogenic differentiation of VSMCs. Following the isolation of VSMCs, the effects of BA on cell proliferation were determined by MTT. The impact of various BA concentrations on the osteogenic differentiation of VSMCs was evaluated by Alizarin red S and alkaline phosphatase (ALP) stainings and the o-cresolphthalein complexone method. In addition, mRNA expressions of osteogenic-related (Runx2 and ALP) and antioxidant system-related genes (Nrf2 and Nqo1) were detected using qRT-PCR analysis. BA treatments did not alter the proliferation of VSMCs. Osteogenic differentiation of VSMCs treated with 100 and 500 μM BA (moderate and high plasma concentrations) was no different from untreated cells. However, increased osteogenic differentiation was observed with the lowest blood level (2 μM) and extremely high BA concentration (1000 μM). Consistent with these results, mRNA expression of Runx2 increased with 2 and 1000 μM BA treatments, while Nrf2 and Nqo1 expressions increased significantly with 100 and 500 μM BA. BA has different effects on VSMCs at various concentrations. The low blood level and too high BA concentration appear detrimental as they increase the osteogenic differentiation of VSMCs in vitro. We propose to investigate BA’s effects and mechanism of action on vascular calcification in vivo.
Modeling and therapeutic targeting of t(8;21) AML with/without TP53 deficiency
Authors: Zhang Wenyu , Li Jingmei , Yamamoto Keita , Goyama Susumu
Published: May 2024

Acute myeloid leukemia (AML) with t(8;21)(q22;q22.1);RUNX1-ETO is one of the most common subtypes of AML. Although t(8;21) AML has been classified as favorable-risk, only about half of patients are cured with current therapies. Several genetic abnormalities, including TP53 mutations and deletions, negatively impact survival in t(8;21) AML. In this study, we established Cas9+ mouse models of t(8;21) AML with intact or deficient Tpr53 (a mouse homolog of TP53) using a retrovirus-mediated gene transfer and transplantation system. Trp53 deficiency accelerates the in vivo development of AML driven by RUNX1-ETO9a, a short isoform of RUNX1-ETO with strong leukemogenic potential. Trp53 deficiency also confers resistance to genetic depletion of RUNX1 and a TP53-activating drug in t(8;21) AML. However, Trp53-deficient t(8;21) AML cells were still sensitive to several drugs such as dexamethasone. Cas9+ RUNX1-ETO9a cells with/without Trp53 deficiency can produce AML in vivo, can be cultured in vitro for several weeks, and allow efficient gene depletion using the CRISPR/Cas9 system, providing useful tools to advance our understanding of t(8;21) AML.
Variation in Hounsfield unit calculated using dual-energy computed tomography: comparison of dual-layer, dual-source, and fast kilovoltage switching technique
Authors: Ohira Shingo , Mochizuki Junji , Niwa Tatsunori , Endo Kazuyuki , Minamitani Masanari , Yamashita Hideomi , Katano Atsuto , Imae Toshikazu , Nishio Teiji , Koizumi Masahiko , Nakagawa Keiichi
Published: May 2024

The purpose of the study is to investigate the variation in Hounsfield unit (HU) values calculated using dual-energy computed tomography (DECT) scanners. A tissue characterization phantom inserting 16 reference materials were scanned three times using DECT scanners [dual-layer CT (DLCT), dual-source CT (DSCT), and fast kilovoltage switching CT (FKSCT)] changing scanning conditions. The single-energy CT images (120 or 140 kVp), and virtual monochromatic images at 70 keV (VMI70) and 140 keV (VMI140) were reconstructed, and the HU values of each reference material were measured. The difference in HU values was larger when the phantom was scanned using the half dose with wrapping with rubber (strong beam-hardening effect) compared with the full dose without the rubber (reference condition), and the difference was larger as the electron density increased. For SECT, the difference in HU values against the reference condition measured by the DSCT (3.2 ± 5.0 HU) was significantly smaller (p < 0.05) than that using DLCT with 120 kVp (22.4 ± 23.8 HU), DLCT with 140 kVp (11.4 ± 12.8 HU), and FKSCT (13.4 ± 14.3 HU). The respective difference in HU values in the VMI70 and VMI140 measured using the DSCT (10.8 ± 17.1 and 3.5 ± 4.1 HU) and FKSCT (11.5 ± 21.8 and 5.5 ± 10.4 HU) were significantly smaller than those measured using the DLCT120 (23.1 ± 27.5 and 12.4 ± 9.4 HU) and DLCT140 (22.3 ± 28.6 and 13.1 ± 11.4 HU). The HU values and the susceptibility to beam-hardening effects varied widely depending on the DECT scanners.
Genetically Engineered CLDN18.2 CAR-T Cells Expressing Synthetic PD1/CD28 Fusion Receptors Produced Using a Lentiviral Vector
Authors: Lee Heon Ju , Hwang Seo Jin , Jeong Eun Hee , Chang Mi Hee
Published: May 2024

This study aimed to develop synthetic Claudin18.2 (CLDN18.2) chimeric antigen receptor (CAR)-T (CAR-T) cells as a treatment for advanced gastric cancer using lentiviral vector genetic engineering technology that targets the CLDN18.2 antigen and simultaneously overcomes the immunosuppressive environment caused by programmed cell death protein 1 (PD-1). Synthetic CAR T cells are a promising approach in cancer immunotherapy but face many challenges in solid tumors. One of the major problems is immunosuppression caused by PD-1. CLDN18.2, a gastric-specific membrane protein, is considered a potential therapeutic target for gastric and other cancers. In our study, CLDN18.2 CAR was a second-generation CAR with inducible T-cell costimulatory (CD278), and CLDN18.2-PD1/CD28 CAR was a third-generation CAR, wherein the synthetic PD1/CD28 chimeric-switch receptor (CSR) was added to the second-generation CAR. In vitro, we detected the secretion levels of different cytokines and the killing ability of CAR-T cells. We found that the secretion of cytokines such as interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) secreted by three types of CAR-T cells was increased, and the killing ability against CLDN18.2-positive GC cells was enhanced. In vivo, we established a xenograft GC model and observed the antitumor effects and off-target toxicity of CAR-T cells. These results support that synthetic anti-CLDN18.2 CAR-T cells have antitumor effect and anti-CLDN18.2-PD1/CD28 CAR could provide a promising design strategy to improve the efficacy of CAR-T cells in advanced gastric cancer.
Evaluation of Sensitization Behaviors on the Heat-Affected Zone of Austenitic Stainless Steel Weld by Thermal Cycles of Actual Multi-pass Welding
Authors: Kim Gidong , Lee Junho , Kim Seunghyun , Kang Yongjoon , Park Jun-Yong , Song Sang-Woo
Published: May 2024

The sensitization behavior of the welding heat affected zone (HAZ) in austenitic stainless steels (SSs) was investigated through simulated thermal cycles emulating actual multi-pass welding processes using the Gleeble simulator. The tests were performed with austenitic SSs, considering carbon contents, heat input, and distance from the fusion line to determine the thermal cycle conditions of the HAZ. Higher carbon content led to increased sensitization (degree of sensitization, DOS) values, while the influence of the thermal cycle in the final weld pass was that even though it was rapidly heated to over 1000 °C and cooled at a rapid rate, the DOS value decreased due to partial carbide dissolution and chromium diffusion. Therefore, effective management of the final thermal cycle in the HAZ contributes to improved intergranular stress corrosion cracking resistance. Even with prolonged exposure of the HAZ to the sensitization region, the discovery that corrosion resistance improves when the final heating cycle reaches 1000 °C underscores the importance of HAZ heat cycle management and provides valuable insights for materials engineering and industrial applications.

Graphical abstract
CLKR: Conditional Logic and Knowledge Representation
Authors: Beierle Christoph , Haldimann Jonas , Schwarzer Leon
Published: May 2024

CLKR (Conditional Logic and Knowledge Representation) is an online repository of conditional logic resources for knowledge representation and reasoning. The question which entailments should follow from a conditional knowledge base consisting of a set of conditionals “If A then usually B“ is central in logic-based AI. In order to support the practical side of this question, CLKR provides various collections of conditional knowledge bases and related resources. All knowledge bases available in CLKR can be processed directly with a corresponding reasoning system like InfOCF-Web. The sets of knowledge bases include examples as they are used in the literature for illustration, application knowledge bases from different domains, and systematically generated knowledge bases for evaluating implementations of nonmonotonic reasoning. A main emphasis of the current version of CLKR is on providing collections of knowledge bases in various normal forms that have been proposed for conditional knowledge bases, e.g., conditional normal form, antecedent normal form, and renaming normal form.
“Quasi-Metacognitive Machines: Why We Don’t Need Morally Trustworthy AI and Communicating Reliability is Enough”
Authors: Dorsch John , Deroy Ophelia
Published: May 2024

Many policies and ethical guidelines recommend developing “trustworthy AI”. We argue that developing morally trustworthy AI is not only unethical, as it promotes trust in an entity that cannot be trustworthy, but it is also unnecessary for optimal calibration. Instead, we show that reliability, exclusive of moral trust, entails the appropriate normative constraints that enable optimal calibration and mitigate the vulnerability that arises in high-stakes hybrid decision-making environments, without also demanding, as moral trust would, the anthropomorphization of AI and thus epistemically dubious behavior. The normative demands of reliability for inter-agential action are argued to be met by an analogue to procedural metacognitive competence (i.e., the ability to evaluate the quality of one’s own informational states to regulate subsequent action). Drawing on recent empirical findings that suggest providing reliability scores (e.g., F1-scores) to human decision-makers improves calibration in the AI system, we argue that reliability scores provide a good index of competence and enable humans to determine how much they wish to rely on the system.
The impact of professional learning and development on primary and intermediate teachers’ digital technologies knowledge and efficacy beliefs
Authors: Stringer Lynley Rose , Lee Kerry Maree , Sturm Sean , Giacaman Nasser
Published: May 2024

To prepare young people for the increasingly complex and fluid world of their future, many countries have begun introducing digital technologies concepts and skills into their curricula. In 2017, the New Zealand National Curriculum was updated to incorporate digital technologies concepts in both the indigenous Māori-medium curriculum and the English-medium curriculum. This study investigated the long-term impact of three different models of digital technologies in professional learning and development on primary and intermediate schoolteachers’ knowledge and efficacy beliefs (value beliefs, self-efficacy beliefs and teaching efficacy beliefs). Professional learning and development were found to have a positive long-term impact on teachers’ digital technologies knowledge and efficacy beliefs, yet no one professional learning and development model was found to be more effective than another. Post professional learning and development, teachers were found to want more support on how to plan for Digital Technologies curricula implementation and fully adopt twenty-first-century pedagogical practices. School environments were shown to influence efficacy beliefs, and a lack of time in the classroom to plan for and upskill in digital technologies was reported. Limitations of the study are discussed, and areas for future research are identified.
The HWAM-EMD-GRU Forecasting Model for Short-Term Passenger Flow in an Airport Light Rail Transit Line
Authors: Qin Qian , Wang Ziji’an , Li Bing , Huang Ailing
Published: May 2024

Accurate forecasting of airport light rail transit line (ALRTL) outbound passenger flow is critical to the optimal operations of both light rail and airport systems. Considering the nonlinearity, non-stationarity, uncertainty, and periodicity of outbound passenger flow in the ALRTL, we propose a combined forecasting model that integrates the Holt and Winters additive model (HWAM), empirical mode decomposition (EMD) and gated recurrent unit (GRU). Firstly, the edge effect of EMD will greatly affect the performance of the forecasting model. To overcome this, we extend the passenger flow by HWAM. After that, the decomposition method, EMD, can be applied to passenger flow, and several intrinsic mode function (IMF) components can be extracted. After extracting all the IMFs, the remaining part is referred to as the residual (Res) component. Then, a correlation test is performed on all the components, followed by their aggregation. Finally, the GRU is used to predict each of the aggregated components, and the prediction of aggregated components requires reconstruction. To verify the performance of the HWAM-EMD-GRU, we conducted a comparative study on the hourly passenger flow data for Beijing Daxing International Airport Express and set the autoregressive integrated moving average model, HWAM, Prophet, and GRU as the baseline. Predictions of the HWAM-EMD-GRU combined model demonstrated higher accuracy than baseline models, with a root mean square error of 83.52 (Prophet is 110.21) and mean absolute percentage error of 8.32% (Prophet is 12.48 %). The experimental result shows that the HWAM-EMD-GRU forecasting model offers more accurate predictions.
The Lipschitz type of the geometric directional bundle
Authors: Koike Satoshi , Paunescu Laurentiu
Published: May 2024

We investigate the behaviour of the geometric directional bundles, associated to arbitrary subsets in $$\mathbb {R}^n$$

R

n

, under bi-Lipschitz homeomorphisms, and give conditions under which their bi-Lipschitz type is preserved. The most general sets we consider satisfy the sequence selection property (SSP) and, consequently, we investigate the behaviour of such sets under bi-Lipschitz homeomorphisms as well. In particular, we show that the bi-Lipschitz images of subanalytic sets generically satisfy (SSP).
Fault and fracture network characterization using soft computing techniques: application to geologically complex and deeply-buried geothermal reservoirs
Authors: Yasin Qamar , Ding Yan , Du Qizhen , Thanh Hung Vo , Liu Bo
Published: May 2024

Geothermal energy is a sustainable energy source that meets the needs of the climate crisis and global warming caused by fossil fuel burning. Geothermal resources are found in complex geological settings, with faults and interconnected networks of fractures acting as pathways for fluid circulation. Identifying faults and fractures is an essential component of exploiting geothermal resources. However, accurately predicting fractures without high-resolution geophysical logs (e.g., image logs) and well-core samples is challenging. Soft computing techniques, such as machine learning, make it possible to map fracture networks at a finer resolution. This study employed four supervised machine learning techniques (multilayer perceptron (MLP), random forests (RF), extreme gradient boosting (XGBoost), and support vector regression (SVR)) to identify fractures in geothermal carbonate reservoirs in the sub-basins of East China. The models were trained and tested on a diverse well-logging dataset collected at the field scale. A comparison of the predicted results revealed that XGBoost with optimized hyperparameters and data division achieved the best performance than RF, MLP, and SVR with RMSE = 0.02 and R2 = 0.92. The Q-learning algorithm outperformed grid search, Bayesian, and ant colony optimizations. The blind well test demonstrates that it is possible to accurately identify fractures by applying machine learning algorithms to standard well logs. In addition, the comparative analysis indicates that XGBoost was able to handle the complex relationship between input parameters (e.g., DTP > RD > DEN > GR > CAL > RS > U > CNL) and fracture in geologically complex geothermal carbonate reservoirs. Furthermore, comparing the XGBoost model with previous studies proved superior in training and testing. This study suggests that XGBoost with Q-learning-based optimized hyperparameters and data division is a suitable algorithm for identifying fractures using well-log data to explore complex geothermal systems in carbonate rocks.

Graphical abstract
Effect of moisture content on the rockburst intensity of sandstones
Authors: Wang Jianchao , Wang Wei , Chen Guoqing , Wang Yanke
Published: May 2024

Rockburst is a common geological hazard in deep underground engineering, and it often occurs in strata consisting of brittle rocks. In this study, the moisture content effect on the rockburst intensity of sandstones is systematically studied. A series of triaxial unloading compression tests along with the acoustic emission monitoring are performed for sandstone specimens with different moisture content levels. The mechanical properties, failure characteristics, and dilatancy behaviors of sandstone specimens are then properly compared. Comparative results reveal that the triaxial compressive strength and total strain energy of the saturated specimen decrease by about 30% and 35%, respectively, as compared to those of the dry specimen. Moreover, the magnitude of elastic strain energy tends to decrease with the increasing water content. The effect of moisture content on the rockburst intensity of sandstones is, therefore, significant. Besides, it is also found that the onset of dilatancy is generally unaffected by the water content, whereas the extent of dilatancy significantly decreases with the increasing water content. Numerical simulations for a tunnel excavation model confirm that injecting water into the surrounding rock is an effective way of reducing the rockburst intensity during tunnel excavations. These results have a guiding significance for the prevention and control of rockbursts in underground engineering.
Atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction
Authors: Zhu Ding-Han , Zhang Xiong , Li Xiao-Qiang , Li Peng , Wang Yan-Bin , Zhang Shuang
Published: May 2024

In high-altitude nuclear detonations, the proportion of pulsed X-ray energy can exceed 70%, making it a specific monitoring signal for such events. These pulsed X-rays can be captured using a satellite-borne X-ray detector following atmospheric transmission. To quantitatively analyze the effects of different satellite detection altitudes, burst heights, and transmission angles on the physical processes of X-ray transport and energy fluence, we developed an atmospheric transmission algorithm for pulsed X-rays from high-altitude nuclear detonations based on scattering correction. The proposed method is an improvement over the traditional analytical method that only computes direct-transmission X-rays. The traditional analytical method exhibits a maximum relative error of 67.79% compared with the Monte Carlo method. Our improved method reduces this error to within 10% under the same conditions, even reaching 1% in certain scenarios. Moreover, its computation time is 48,000 times faster than that of the Monte Carlo method. These results have important theoretical significance and engineering application value for designing satellite-borne nuclear detonation pulsed X-ray detectors, inverting nuclear detonation source terms, and assessing ionospheric effects.
Key actors in behavioral health services availability and accessibility research: a scoping review bibliometric analysis
Authors: Hooley Cole , Adams Danielle R. , Ng Wai Yan , Wendt Carrie L. E. , Dennis Cory B.
Published: May 2024

This bibliometric review aims to identify key actors in the behavioral health services availability/accessibility literature. Coalescing information about these actors could support subsequent research efforts to improve the availability and accessibility of behavioral health services. The authors used a scoping review method and a bibliometric approach. The articles came from Medline, Embase, Web of Science, CINAHL, and PsycINFO. Articles were included if they assessed behavioral health service availability or accessibility quantitatively and were written in English. The final sample included 265 articles. Bibliometric data were extracted, coded, and verified. The authors analyzed the data using univariate and social network analyses. Publishing in this area has become more consistent and has grown since 2002. Psychiatric Services and Graduate Theses were the most frequently used publication venues. The National Institute on Drug Abuse, National Institute of Mental Health, and the Veterans Administration funded the most research. The most frequently used keyword was “health services accessibility.” The findings suggest that this literature is growing. There are a few clusters of researchers in this area. Government organizations primarily fund this research. The paper and supplementary materials list the top researchers, publication venues, funding sources, and key terms to promote further behavioral health availability/accessibility research.
Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases
Authors: Yong Yu , Cai Yicong , Lin Jiawei , Ma Lin , Han HongBin , Li Fenfang
Published: May 2024

Cells in the brain are surrounded by extracellular space (ECS), which forms porous nets and interconnected routes for molecule transportation. Our view of brain ECS has changed from a largely static compartment to dynamic and diverse structures that actively regulate neural activity and brain states. Emerging evidence supports that dysregulation of brain ECS contributes to the pathogenesis and development of many neurological disorders, highlighting the importance of therapeutic modulation of brain ECS function. Here, we aim to provide an overview of the regulation and dysfunction of ECS in healthy and pathological brains, as well as advanced tools to investigate properties of brain ECS. This review emphasizes modulation methods to manipulate ECS with implications to restore their function in brain diseases.

Graphical Abstract
Revisiting swimming against tide; inequalities in child malnutrition in Nepal
Authors: Siddiqui Mohammad Zahid , Illiyan Asheref , Akram Vasim , Nigar Kashfi
Published: May 2024

Background

Child stunting, child underweight, and child wasting in Nepal decreased from 48%, 47%, and 11% to 25%, 19%, and 9%, respectively, between 1996 and 2022. Despite an overall reduction in prevalence rates, economically poor and geographically backward regions in Nepal have not seen equivalent improvement in child undernutrition similar to their richer and developed regions, leading to increased differences in undernutrition prevalence across the wealth quintiles. This study aimed to assess time trends in the average and inequality of child nutritional status by household wealth across Nepal's geographical spaces from 1996 to 2022.

Methods

This study utilized data from four rounds (1996, 2006, 2016, and 2022) of the Nepal Demographics and Health Survey (NDHS). The nutritional status of children below three years of age, measured by stunting, wasting, and underweight, served as the main dependent variable. Household wealth status, determined by binary responses regarding possession of household assets, acted as a proxy for economic status. The study employed point prevalence for average, Concentration Index (CI), Poorest-Richest-Ratio (P-R-R), and Poorer-Richer-Ratio (Pr-Rr-R) to analyze trends in child nutritional status by wealth quintiles.

Results

From 1996 to 2022, Nepal exhibited an increasing Concentration Index and an upward trend in P-R-R measures of inequality in child stunting. The P-R-R increased from 1.77 in 1996 to 2.51 in 2022, However, results show a concurrent decrease in Pr-Rr-R from 1.19 to 1.18, assessing the prevalence of stunting among children. In the prevalence of child underweight, the P-R-R and Pr-Rr-R were 1.88 and 1.19 in 1996, decreasing to 1.47 and 1.10, respectively, in 2022.

Conclusion

The results indicated that inequalities in child nutrition across wealth status show an increase in stunting but marginal decline in underweight and wasting. Therefore, the study underscores the need for inclusive policy and program interventions to achieve equitable improvement in child stunting in Nepal, ensuring that progress extends to children in the poorest wealth quintile households. However, the progress is equitable in child underweight and wasting.
Screening for Cognitive Impairment in Bilinguals: What Is the Influence of the Language of Assessment?
Authors: Kassir Rania , Roussel Martine , Abboud Halim , Godefroy Olivier
Published: May 2024

Background:

Bilingualism’s impact on cognitive assessment remains underexplored. This study analyzes the efficacy of the Mini-Mental State Examination (MMSE) as a screening tool for bilinguals, specifically examining the influence of language choice on balanced and unbalanced Lebanese bilinguals (Arabic-French) and its implications for diagnosing cognitive impairment.

Methods:

Ninety-three bilingual healthy controls (mean age = 67.99 ± 9.3) and 29 Alzheimer’s disease patients (mean age = 77.2 ± 5.9), including 26 with mild and 3 with moderate dementia, underwent MMSE assessments in both Arabic and French. The study aimed to assess language impact on cognitive screening outcomes in different bilingual subtypes.

Results:

Sensitivity in screening for cognitive impairment using the MMSE varied based on language and bilingualism subtype. For unbalanced bilinguals, using the prominent language increased sensitivity. Conversely, in balanced bilinguals, employing the societal majority language enhanced sensitivity. This suggests that the conventional use of the non-prominent language in cognitive screening for foreigners/immigrants may result in a subtle loss of MMSE sensitivity.

Conclusion:

This study emphasizes the critical role of language choice in cognitive assessment for bilinguals. The MMSE’s sensitivity is influenced by language selection, with clinical implications for screening procedures. Recommendations include using the prominent language for cognitive screening in dominant bilinguals and the societal majority language for balanced bilinguals. This nuanced approach aims to improve the accuracy and cultural sensitivity of cognitive screening in bilingual populations, addressing the gap in current assessment practices.
Screening and Analysis of SARS-CoV-2 Antibody Among Unvaccinated Blood Donors in Chongqing, China
Authors: Jiang Yulin , Huang Lijuan , Liao Hongmei , Luo Chenghui , Zhang Chunhong , Mao Wei
Published: May 2024

Objective:

To investigate the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody among unvaccinated voluntary blood donors in Chongqing, and to provide evidence for epidemic surveillance.

Methods:

A total of 10,208 voluntary blood donors from January 5 to January 20, 2021, in the Chongqing area were collected, and the SARS-CoV-2 immunoglobulin (Ig) G and IgM antibodies were detected by chemiluminescence, and the differences of antibody-positive rate in different gender, age, ABO blood group, and different risk areas were analyzed.

Results:

Among 10208 blood donors, 10 were found to be positive for SARS-COV-2 IgG antibody, giving a positivity rate of SARS-COV-2 IgG at 0.10%, and 29 were positive for SARS-CoV-2 IgM antibody, with a positivity rate of SARS-CoV-2 IgM at 0.28%. There was no statistical difference in the positive rate of antibody among different genders, ages, and ABO blood types, but it was related to the number of confirmed coronavirus disease 2019 (COVID-19) cases in each city.

Conclusions:

The SARS-CoV-2 seroprevalence rate in Chongqing was low and correlated with the number of confirmed COVID-19 cases.
Does bride price harm women? Using ethnography to think about causality
Authors: Brandl Eva , Colleran Heidi
Published: May 2024

Many institutions claim that bride price – where the groom's family transfers wealth to the bride's family at marriage – harms women. Owing to its long-term engagement with communities that practise bride price, ethnography is well placed to identify causal mechanisms at play in this issue, and there is a substantial literature on its effects in a variety of world regions, including Melanesia. Here, we condense this literature, drawing out key causal arguments made about bride price in various Melanesian societies. This reveals a complex, multi-causal picture: rather than being singularly harmful, bride price may involve a mixture of drawbacks and benefits, making it a double-edged sword with contested implications. Bride price may constrain women's options before and during the marriage but also serves as a safety net that enhances their status. Its effects are probably influenced by many other variables, including age, kinship networks and residence structures. These dynamics have been transformed by conversion to Christianity, the (post-)colonial state, market integration, urbanisation and formal education, often yielding ambiguous outcomes. Rather than reducing ethnography to a collection of datapoints, we show that it can serve as a source of verbal arguments that can be used to challenge reductive narratives about sensitive issues and to formulate hypotheses for testing with quantitative data.
Learned Women, “Leftover” Women, and “The Third Sex” Women's Learning in the Confucian Tradition and Contemporary China
Authors: Hu Jing Iris
Published: May 2024

This paper investigates women's learning experiences in the Confucian tradition and the social dismay and stigma associated with them. Despite being considered a meta-virtue in the Confucian tradition, learning becomes rather complex when women are the learners. It is viewed by learned women as a curse rather than a blessing in pre-modern China; it is associated with the stigma of “leftover women” and “the third sex” in contemporary China. Based on an examination of works written by women thinkers, I argue that the asymmetry in social recognition for men's and women's learning is rooted in the social and family structure of nei (in) and wai (out), which does not assign sufficient cultural and moral significance to learning achieved in the nei domain nor permit its continuous and accumulative existence. I propose two preliminary steps to rectify the issue of the lack of social and moral recognition of women's learning: first, a reforming of the nei and wai structure to allow assigning more moral, cultural, and normative significance to affairs in the nei domain. Second, re-examine and utilize classical Confucian texts such as the Mencius and later works by women writers to support and guide such reformations.
What Rayleigh numbers are achievable under Oberbeck–Boussinesq conditions?
Authors: Weiss Stephan , Emran Mohammad S. , Shishkina Olga
Published: May 2024

The validity of the Oberbeck–Boussinesq (OB) approximation in Rayleigh–Bénard (RB) convection is studied using the Gray & Giorgini (Intl J. Heat Mass Transfer, vol. 19, 1976, pp. 545–551) criterion that requires that the residuals, i.e. the terms that distinguish the full governing equations from their OB approximations, are kept below a certain small threshold

$\hat {\sigma }$

. This gives constraints on the temperature and pressure variations of the fluid properties (density, absolute viscosity, specific heat at constant pressure

$c_p$

, thermal expansion coefficient and thermal conductivity) and on the magnitudes of the pressure work and viscous dissipation terms in the heat equation, which all can be formulated as bounds regarding the maximum temperature difference in the system,

$\varDelta$

, and the container height,

$L$

. Thus for any given fluid and

$\hat {\sigma }$

, one can calculate the OB-validity region (in terms of

$\varDelta$

and

$L$

) and also the maximum achievable Rayleigh number

${{Ra}}_{max,\hat {\sigma }}$

, and we did so for fluids water, air, helium and pressurized SF

$_6$

at room temperature, and cryogenic helium, for

$\hat {\sigma }=5\,\%$

,

$10\,\%$

and

$20\,\%$

. For the most popular fluids in high-

${{Ra}}$

RB measurements, which are cryogenic helium and pressurized SF

$_6$

, we have identified the most critical residual, which is associated with the temperature dependence of

$c_p$

. Our direct numerical simulations (DNS) showed, however, that even when the values of

$c_p$

can differ almost twice within the convection cell, this feature alone cannot explain a sudden and strong enhancement in the heat transport in the system, compared with its OB analogue.
Data, disclosure and duties: balancing privacy and safeguarding in the context of UK university student sexual misconduct complaints
Authors: Cowan Sharon , Munro Vanessa E , Bull Anna , DiSantis Clarissa J , Prince Kelly
Published: May 2024

The past decade has seen a marked shift in the regulatory landscape of UK higher education. Institutions are increasingly assuming responsibility for preventing campus sexual misconduct, and are responding to its occurrence through – amongst other things – codes of (mis)conduct, consent and/or active bystander training, and improved safety and security measures. They are also required to support victim-survivors in continuing with their education, and to implement fair and robust procedures through which complaints of sexual misconduct are investigated, with sanctions available that respond proportionately to the seriousness of the behaviour and its harms. This paper examines the challenges and prospects for the success of university disciplinary processes for sexual misconduct. It focuses in particular on how to balance the potentially conflicting rights to privacy held by reporting and responding parties within proceedings, while respecting parties’ rights to equality of access to education, protection from degrading treatment, due process, and the interests of the wider campus community. More specifically, we explore three key moments where private data is engaged: (1) in the fact and details of the complaint itself; (2) in information about the parties or circumstances of the complaint that arise during the process of an investigation and/or resultant university disciplinary process; and (3) in the retention and disclosure (to reporting parties or the university community) of information regarding the outcomes of, and sanctions applied as part of, a disciplinary process. We consider whether current data protection processes – and their interpretation – are compatible with trauma-informed practice and a wider commitment to safety, equality and dignity, and reflect on the ramifications for all parties where that balance between rights or interests is not struck.
Freedom Inc.: Gendered Capitalism in New Indian Literature and Culture: A Response
Authors: Iyer Nalini
Published: May 2024

This essay is a response to Mukti Mangharam’s book Freedom Inc: Gendered Capitalism in New Indian Literature and Culture. The essay commends Mangharam’s intervention in reading the gender, caste, and class implications of neoliberalism embraced by the Indian government and people. Drawing upon Mangharam’s main arguments, this essay extends her analysis to examining the role of the Indian diaspora in promoting Freedom Inc’s narrative, the increased marginalization and precarity faced by Muslims within this new India, and the insidious ways in which Freedom Inc coopts narratives that critique it.
Honeycomb structure filling morphing wing trailing edge: Design strategy, deformation feedback, and active control
Authors: Li Xuyang , Sun Lianfa , Pan Yang , Guo Xiaogang
Published: May 2024

Pursuing highly efficient aerodynamic efficiency in aircraft has driven the development of morphing wing technology. However, there are still limitations to morphing wing technology, including adaptation of load and deformation, and deformation monitoring and control. This work introduces an intelligent trailing edge structure that balances deformation and load-bearing and achieves deformation monitoring and active control. Firstly, we employ a honeycomb structure for non-uniform filling of the trailing edge. The filling method is obtained through inverse design using a genetic algorithm based on neural networks, allowing the device to undergo continuous deformation while meeting load-bearing requirements. The bending deformation of the wing is achieved using shape memory alloy (SMA) wire. Additionally, we design and fabricate a metal-based multichannel flexible sensor, and based on beam bending theory, we establish the strain–displacement relationship. These sensors are affixed to the trailing edge surface, enabling real-time monitoring and active control of trailing edge deformation. Building an experimental platform to test this system, the results show that the sensors can accurately give feedback on the degree of wing deformation, and the error of active deformation control technology is less than 4%. This provides a new method for the deformation feedback control closed-loop system of intelligent variant wings.
Does (Non-)Localness Affect MPs’ Levels of Responsiveness? Evidence from a UK Field Experiment
Authors: Bolet Diane , Campbell Rosie
Published: May 2024

Does an MP's localness affect their behaviour towards constituents? Existing research has shown biases in MPs' responsiveness to citizens based on citizens' sociodemographic and political traits and voters’ tendency to prefer ‘local’ MPs. Yet, we know little about whether MPs' localness affects their responsiveness to constituents. MPs' localness may influence their behaviour for strategic reasons and/or because of homophily. To explore this relationship, we conducted a field experiment in the United Kingdom where we asked legislators about their policy priorities regarding the COVID-19 pandemic. We found that local MPs do not differentiate in their responsiveness to constituents. However, non-local MPs are motivated by party affiliation and gender in their responsiveness to constituents, with ethnicity and class playing insignificant roles. Non-local MPs respond more to co-partisans than non-partisans and women non-local MPs are more responsive to women constituents. This experiment underscores the impact of (non-)localness on MPs' interactions with constituents.
Les courants nationalistes à l’épreuve des générations : analyses des attitudes et choix de vote des Québécois.es de 2007 à 2022
Authors: Mahéo Valérie-Anne , Bélanger Éric
Published: May 2024

L'existence et la persistance de mouvements nationalistes peuvent avoir plusieurs explications, dont l'une est liée aux générations – à la façon dont elles ont été socialisées à la politique dans des contextes sociétaux distincts, et comment les générations plus âgées sont remplacées par les plus jeunes à travers le temps. Pour mieux comprendre l’évolution du nationalisme au Québec, cette étude s'appuie sur les six dernières Études électorales québécoises (2007–2022) et utilise un modèle âge-période-cohorte pour examiner la relation entre les groupes générationnels et divers indicateurs du nationalisme. Les résultats révèlent effectivement une histoire générationnelle. Les baby-boomers se distinguent particulièrement des autres générations par leur attachement au Québec, leur soutien au projet d'indépendance et leur appui au Parti québécois, tandis que les millénariaux soutiennent davantage Québec solidaire et les membres de la génération X appuient davantage la Coalition avenir Québec. Ainsi, il cohabite actuellement différentes « générations nationalistes » au Québec.
HORSEPLAY IN PLAUTUS’ ASINARIA
Authors: Pieczonka Joanna
Published: May 2024

This article argues that the game presented in the third scene of the third act of Plautus’ Asinaria involves a horseplay rather than an assplay (Asin. 697–710). This is suggested by the young master's name, Argyrippus, and by a list of equine terms occurring in the text: uehere, inscendere, descendere, subdomari, tolutim, quadrupedo, aduorsom cliuom, in procliui.
ERIS: A WORDPLAY IN CATULLUS 40
Authors: Trafford Simon
Published: May 2024

In poem 40, through a series of rhetorical questions, Catullus confronts Ravidus about what made him commit such a foolish action as to fall in love with Catullus’ own lover. The poem ends with the lines: eris, quandoquidem meos amores | cum longa uoluisti amare poena, ‘You will be, since you have chosen to love my lover at the risk of receiving a long punishment’. There is a long-standing tradition of scholarship which testifies to the frequency with which Catullus incorporates wordplay in his poems, including bilingual puns. This essay proposes another such pun by arguing that Catullus is making a play on words through the homophony of the Latin verb eris and the Greek noun ἔρις.
Central Europe in the Fifteenth Century: Patterns of Conflict and Negotiation
Authors: Lutter Christina , Lyon Jonathan
Published: May 2024

The nine articles in this collection are the product of two workshops hosted at the University of Chicago in 2022 and 2023 in affiliation with the University of Vienna. They build on recent work that has called attention to the extraordinary political and religious diversity in the fifteenth-century Holy Roman Empire, and Central Europe more broadly. Pushing back against older historiography, in which this period was frequently overlooked or framed by uncritical use of such broad categories as the “state,” the “territory,” the “estates,” and the “feud,” this collection recognizes the polycentric nature of the fifteenth century's structures and institutions. Specifically, these articles return to the sources, especially documents of practice rather than normative texts, to open the door to a new understanding of conflicts and negotiations. They illuminate the patterns of conflict and negotiation evident in specific historical contexts by examining actors, networks, and practices of community building—as well as the processes through which conflicts emerged, evolved, and were negotiated and settled. Rather than relying on time-honored categories and meta-narratives, the contributors embrace the messiness of social and political relations and of the extant source material to shine new light on key themes in the fifteenth century's history.
Digital multimodal composing in L2 classrooms: A research agenda
Authors: Jiang Lianjiang (George) , Hafner Christoph
Published: May 2024

Research on digital multimodal composing (DMC) in second language (L2) classrooms has proliferated considerably in recent years, to a large extent in response to the changing digital and multimodal communication landscape. This article offers a research agenda on DMC in L2 classrooms. We begin with a theoretically oriented overview of DMC scholarship. We then examine seven research themes for future research inquiry, from which we draw seven research tasks. The seven themes are: (1) the effectiveness of DMC for L2 writing development; (2) DMC task design; (3) L2 teacher education/training for implementing DMC; (4) feedback practice for DMC; (5) DMC assessment; (6) collaborative DMC as a translanguaging space; and (7) the deployment of DMC for critical digital literacies. Throughout the article, we refer to interdisciplinary scholarship and methods from multimodality, L2 writing, composition studies, new literacy studies, language teacher education, and computer-assisted language learning. The seven research tasks represent what we see as the essential next steps for understanding DMC, which is a young domain that has great potential to advance L2 language and literacy education in the digital age.