bluuebunny/crossref_metadata_2025 huggingface dataset:
Osteoprotegerin deficiency aggravates methionine–choline-deficient diet-induced nonalcoholic steatohepatitis in mice
Authors: Wu Shaobo , Wu Yao , Lin Lan , Ruan Changshun , Li Fang , Chen Rong , Du Hongxin , Zhang Xianxiang , Luo Xiaohe
Published: February 2023

Clinical studies have shown that osteoprotegerin (OPG) is reduced in patients with nonalcoholic steatohepatitis (NASH), but the underlying mechanisms are unclear. The current study focuses on the role of OPG in the NASH pathogenesis. OPG knockout mice and wild-type control mice fed a methionine choline-deficient diet (MCD) for 4 weeks resulted in an animal model of NASH. Measurement of triglycerides (TG) in serum and liver to assess steatosis. Hematoxylin eosin (HE), Sirius Red and Masson staining were used to assess the liver damage. Transcriptome sequencing analysis, qPCR and western blot were to analyze changes in lipid metabolism and inflammation-related indicators in the liver. In vivo knockout of OPG resulted in a reduction of TG levels in the liver and a significant increase in serum ALT and AST. The expression of inflammatory factors and fibrosis genes was significantly upregulated in the livers of OPG knockout mice. Transcriptome sequencing analysis showed that OPG knockout significantly enhanced MCD diet-induced activation of the mitogen-activated protein kinase (MAPK) signaling pathway. Mechanistically, OPG may inhibit MAPK signaling pathway activity by upregulating the expression of dual specificity phosphatase 14 (DUSP14), thereby reducing inflammatory injury. OPG could regulate the activity of the MAPK signaling pathway via DUSP14, thus regulating the expression of some inflammatory factors in NASH, it may be a promising target for the treatment of NASH.
Numerical solution of neutral delay differential equations using orthogonal neural network
Authors: Vinodbhai Chavda Divyesh , Dubey Shruti
Published: February 2023

In this paper, an efficient orthogonal neural network (ONN) approach is introduced to solve the higher-order neutral delay differential equations (NDDEs) with variable coefficients and multiple delays. The method is implemented by replacing the hidden layer of the feed-forward neural network with the orthogonal polynomial-based functional expansion block, and the corresponding weights of the network are obtained using an extreme learning machine(ELM) approach. Starting with simple delay differential equations (DDEs), an interest has been shown in solving NDDEs and system of NDDEs. Interest is given to consistency and convergence analysis, and it is seen that the method can produce a uniform closed-form solution with an error of order$$2^{-n}$$2-n, wherenis the number of neurons. The developed neural network method is validated over various types of example problems(DDEs, NDDEs, and system of NDDEs) with four different types of special orthogonal polynomials.
A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis
Authors: Rottenaicher Georg J. , Absmeier Ramona M. , Meier Laura , Zacharias Martin , Buchner Johannes
Published: February 2023

Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell clones, misfold and form insoluble fibrils, which can be deposited in various organs. In the majority of cases, the fibrillar deposits consist of LC variable domains (VL) containing destabilizing mutations compared to their germline counterparts. This is also true for the patient LC FOR005. However, this pathogenic LC sequence contains an additional mutation in the constant domain (CL). The mechanistic impact of CL mutations is not yet understood in the context of AL amyloidosis. Our analysis reveals that the FOR005 CL mutation influences the amyloid pathway in specific ways: (1) folding and stability of the patient CL domain are strongly impaired; (2) the mutation disrupts the LC dimer interface and weakens dimerization; (3) the CL mutation promotes proteolytic cleavage of the LC monomers resulting in an isolated, amyloidogenic VL domain while dimeric LCs are not cleaved. The enhanced proteolysis rates and the inability of full-length LCs to form amyloid fibrils even in the presence of a destabilized CL domain support a model for AL amyloidosis in which the CL domain plays a protective role and in which proteolytic cleavage precedes amyloid formation.
Assessment of the drugability of initial malaria infection through miniaturized sporozoite assays and high-throughput screening
Authors: Miglianico Marie , Bolscher Judith M. , Vos Martijn W. , Koolen Karin J. M. , de Bruijni Marloes , Rajagopal Deeya S. , Chen Emily , Kiczun Michael , Gray David , Campo Brice , Sauerwein Robert W. , Dechering Koen J.
Published: February 2023

The sporozoite stages of malaria parasites are the primary cause of infection of the vertebrate host and are targeted by (experimental) vaccines. Yet, little is known about their susceptibility to chemical intervention. Phenotypic high-throughput screens have not been feasible due to a lack of in vitro systems. Here we tested 78 marketed and experimental antimalarial compounds in miniaturized assays addressing sporozoite viability, gliding motility, hepatocyte traversal, and intrahepatocytic schizogony. None potently interfered with sporozoite viability or motility but ten compounds acted at the level of schizogony with IC50s < 100 nM. To identify compounds directly targeting sporozoites, we screened 81,000 compounds from the Global Health Diversity and reFRAME libraries in a sporozoite viability assay using a parasite expressing a luciferase reporter driven by the circumsporozoite promoter. The ionophore gramicidin emerged as the single hit from this screening campaign. Its effect on sporozoite viability translated into reduced gliding motility and an inability of sporozoites to invade human primary hepatocytes and develop into hepatic schizonts. While providing proof of concept for a small molecule sporontocidal mode of action, our combined data indicate that liver schizogony is more accessible to chemical intervention by (candidate) antimalarials.
A recyclable stereoauxiliary aminocatalyzed strategy for one-pot synthesis of indolizine-2-carbaldehydes
Authors: Zeng Kui , Mei Ruhuai , Dechert Sebastian , Ackermann Lutz , Zhang Kai
Published: February 2023

Indolizine-carbaldehydes with the easily modifiable carbaldehyde group are important synthetic targets as versatile precursors for distinct indolizines. However, the efficient one-pot construction of trisubstituted indolizine-2-carbaldehydes represents a long-standing challenge. Herein, we report an unprecedented recyclable stereoauxiliary aminocatalytic approachviaaminosugars derived from biomass, which enable the efficient one-pot synthesis of desired trisubstituted indolizine-2-carbaldehydesvia[3+2] annulations of acyl pyridines andα,β-unsaturated aldehyde. Compared to the steric shielding effect fromα-anomer, a stereoauxiliary effect favored byβ-anomer of D-glucosamine is supported by control experiments. Furthermore, polymeric chitosan containing predominantlyβ-D-anhydroglucosamine units also shows excellent catalytic performance in aqueous solutions for the conversion of various substrates, large-scale synthesis and catalytic cycling experiments. Thus, our approach advances the existing methodologies by providing a rich library of indolizine-2-aldehydes. In addition, it delivers an efficient protocol for a set of late-stage diversification and targeted modifications of bioactive molecules or drugs, as showcased with 1,2,3-trisubstituted indolizine-2-carbaldehydes.
Shifts in flood generation processes exacerbate regional flood anomalies in Europe
Authors: Tarasova Larisa , Lun David , Merz Ralf , Blöschl Günter , Basso Stefano , Bertola Miriam , Miniussi Arianna , Rakovec Oldrich , Samaniego Luis , Thober Stephan , Kumar Rohini
Published: February 2023

Anomalies in the frequency of river floods, i.e., flood-rich or -poor periods, cause biases in flood risk estimates and thus make climate adaptation measures less efficient. While observations have recently confirmed the presence of flood anomalies in Europe, their exact causes are not clear. Here we analyse streamflow and climate observations during 1960-2010 to show that shifts in flood generation processes contribute more to the occurrence of regional flood anomalies than changes in extreme rainfall. A shift from rain on dry soil to rain on wet soil events by 5% increased the frequency of flood-rich periods in the Atlantic region, and an opposite shift in the Mediterranean region increased the frequency of flood-poor periods, but will likely make singular extreme floods occur more often. Flood anomalies driven by changing flood generation processes in Europe may further intensify in a warming climate and should be considered in flood estimation and management.
Importance of mobile genetic element immunity in numerically abundant Trichodesmium clades
Authors: Webb Eric A , Held Noelle A , Zhao Yiming , Graham Elaina D , Conover Asa E , Semones Jake , Lee Michael D , Feng Yuanyuan , Fu Fei-xue , Saito Mak A , Hutchins David A
Published: February 2023

The colony-forming cyanobacteria Trichodesmium spp. are considered one of the most important nitrogen-fixing genera in the warm, low nutrient ocean. Despite this central biogeochemical role, many questions about their evolution, physiology, and trophic interactions remain unanswered. To address these questions, we describe Trichodesmium pangenomic potential via significantly improved genomic assemblies from two isolates and 15 new >50% complete Trichodesmium metagenome-assembled genomes from hand-picked, Trichodesmium colonies spanning the Atlantic Ocean. Phylogenomics identified ~four N2 fixing clades of Trichodesmium across the transect, with T. thiebautii dominating the colony-specific reads. Pangenomic analyses showed that all T. thiebautii MAGs are enriched in COG defense mechanisms and encode a vertically inherited Type III-B Clustered Regularly Interspaced Short Palindromic Repeats and associated protein-based immunity system (CRISPR-Cas). Surprisingly, this CRISPR-Cas system was absent in all T. erythraeum genomes, vertically inherited by T. thiebautii, and correlated with increased signatures of horizontal gene transfer. Additionally, the system was expressed in metaproteomic and transcriptomic datasets and CRISPR spacer sequences with 100% identical hits to field-assembled, putative phage genome fragments were identified. While the currently CO2-limited T. erythraeum is expected to be a ‘winner’ of anthropogenic climate change, their genomic dearth of known phage resistance mechanisms, compared to T. thiebautii, could put this outcome in question. Thus, the clear demarcation of T. thiebautii maintaining CRISPR-Cas systems, while T. erythraeum does not, identifies Trichodesmium as an ecologically important CRISPR-Cas model system, and highlights the need for more research on phage-Trichodesmium interactions.
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis
Authors: Wang Zhihua , Zhang Xi , Lu Shu , Zhang Chuankai , Ma Zhe , Su Rui , Li Yuanfang , Sun Ting , Li Yutao , Hong Mingyang , Deng Xinyi , Rafiee Monjezi Mohammad , Hristov Michael , Steffens Sabine , Santovito Donato , Dornmair Klaus , Ley Klaus , Weber Christian , Mohanta Sarajo K. , Habenicht Andreas J. R. , Yin Changjun
Published: February 2023

Atherosclerotic plaques form in the inner layer of arteries triggering heart attacks and strokes. Although T cells have been detected in atherosclerosis, tolerance dysfunction as a disease driver remains unexplored. Here we examine tolerance checkpoints in atherosclerotic plaques, artery tertiary lymphoid organs and lymph nodes in mice burdened by advanced atherosclerosis, via single-cell RNA sequencing paired with T cell antigen receptor sequencing. Complex patterns of deteriorating peripheral T cell tolerance were observed being most pronounced in plaques followed by artery tertiary lymphoid organs, lymph nodes and blood. Affected checkpoints included clonal expansion of CD4+, CD8+ and regulatory T cells; aberrant tolerance-regulating transcripts of clonally expanded T cells; T cell exhaustion; Treg–TH17 T cell conversion; and dysfunctional antigen presentation. Moreover, single-cell RNA-sequencing profiles of human plaques revealed that the CD8+ T cell tolerance dysfunction observed in mouse plaques was shared in human coronary and carotid artery plaques. Thus, our data support the concept of atherosclerosis as a bona fide T cell autoimmune disease targeting the arterial wall.
Research status of volatile organic compound (VOC) removal technology and prospect of new strategies: a review
Authors: Li Siwen , Lin Yingzi , Liu Gen , Shi Chunyan
Published: February 2023

The reaction mechanism on the right is realized in device 6 and the performance of the particle electrode is improved by the bimetallic load. The efficient removal of VOCs is achieved by the overall system.
Phenolic-rich extract ofNopalea cochenilliferaattenuates gastric lesions induced in experimental models through inhibiting oxidative stress, modulating inflammatory markers and a cytoprotective effect
Authors: da Silva Elaine Cristine Souza , Bernardo Guerra Gerlane Coelho , de Araújo Edilane Rodrigues Dantas , Schlamb Jade , da Silva Valéria Costa , de Aragão Tavares Emanuella , Dantas-Medeiros Renato , Abreu Lucas Silva , Fechine Tavares Josean , de Araújo Júnior Raimundo Fernandes , Esposito Debora , Moncada Marvin , Maria Zucolotto Silvana
Published: February 2023

Nopalea cochenillifera(Cactaceae), popularly known as “palma” or “palma doce”, is from Mexico, but it was widely introduced in Brazil through crops.
Ligand evolution on trigonal bipyramidal boron imidazolate cages for enhanced optical limiting
Authors: Chen Jun-Qiang , Zhang Hai-Xia , Wang Zhi-Run , Hong Qin-Long , Zhang Jian
Published: February 2023

We synthesized here a series of trigonal bipyramidal cages, [M5L6], which can realized the modulations of stacking modes, conjugation degree, electronic push–pull effects and band gaps. BIF-141 achieves excellent optical limiting (OL) performance.
Accurate non-covalent interaction energies on noisy intermediate-scale quantum computers via second-order symmetry-adapted perturbation theory
Authors: Loipersberger Matthias , Malone Fionn D. , Welden Alicia R. , Parrish Robert M. , Fox Thomas , Degroote Matthias , Kyoseva Elica , Moll Nikolaj , Santagati Raffaele , Streif Michael
Published: February 2023

Proposed quantum algorithm for accurate non-covalent interactions on noisy intermediate-scale quantum computers. Combining molecular wavefunctions from the quantum computing and classical post procressing using symmetry-adapted perturbation theory.
Aqueous eutectic hydrogel electrolytes enable flexible thermocells with a wide operating temperature range
Authors: Peng Peng , Li Zhao , Xie Daibin , Zhu Kaihua , Du Chunyu , Liang Lirong , Liu Zhuoxin , Chen Guangming
Published: February 2023

A flexible thermocell with good freeze-tolerance and self-humidifying capabilities is rationally designed. Its high adaptability to temperature fluctuations and environmental changes can promote low-grade heat harvesting under extreme conditions.
Organic and inorganic nanomedicine for combination cancer therapies
Authors: Lee Donghyun , Shin Jeongsu , Son Hangyu , Cheon Seo Young , Lee Yeeun , Park Joonhyuck , Koo Heebeom
Published: February 2023

To improve cancer treatment, various organic and inorganic nanomedicine has been studied widely combining chemo-, photodynamic-, photothermal-, radio-, and immunotherapy.
Pd-catalyzed exclusively regioselective [5 + 4] cycloaddition for the construction of 1,5-di/ox-azonanes
Authors: Liu Wenqi , Zang Meng , Zhang Jian , Wang Quannan , Liu Yang-Zi , Deng Wei-Ping
Published: February 2023

An efficient approach for the exclusively regioselective construction of 1,5-di/ox-azonanesviaPd-catalyzed [5 + 4] cycloaddition has been developed.
Correction: Evaporation-driven liquid flow in sessile droplets
Authors: Gelderblom Hanneke , Diddens Christian , Marin Alvaro
Published: February 2023

Correction for ‘Evaporation-driven liquid flow in sessile droplets’ by Hanneke Gelderblom et al., Soft Matter, 2022, 18, 8535–8553, https://doi.org/10.1039/D2SM00931E.
Zirconium pentatelluride as saturable absorber for 2 μm ultrafast solid-state laser
Authors: Cai Enlin , Qi Chun , Hu Xiaohui , Du Long , Hao Linhong , Zhang Shuaiyi , Lou Fei , Wang Maorong , Li Tao , Wang Aifeng
Published: February 2023

2 μm ultrafast pulses as short as 4.8 ps are obtained with a maximum average output power of 767 mW. This is the highest average output power achieved so far, for a passively mode-locked laser at 2 μm using a two-dimensional saturable absorber.
Induced microwave scattering in the ITER edge transport barrier at ECRH and possibility of its modeling at ASDEX-Upgrade
Authors: Gusakov Evgeniy , Popov Alexei , Irzak Michael
Published: February 2023

The induced scattering parametric decay instability of O-mode polarized microwaves leading to excitation of lower hybrid or electron plasma waves localized within a tokamak edge transport barrier is investigated. Numerical estimates of the instability threshold and its growth rate for this scenario are given for the conditions of O2-mode ECRH experiments at ASDEX-Upgrade, where experimental investigation of these phenomena is possible.
Plasma heating and improvement of lower hybrid current drive efficiency by electron cyclotron waves on EAST
Authors: Li Miaohui , Xu Handong , Wang Xiaojie , Wang Mao , Ding Bojiang , Xu Weiye , Wu Dajun , Tang Yunying , Zhang Liyuan , Wu Zege , Wang Jian , Zhang Tao , Wang Hanlin , Zang Qing , Zhao Hailin , Liu Haiqing , Qian Jinping , Gong Xianzu , Liu Fukun , Zou Xiaolan
Published: February 2023

The electron cyclotron (EC) system on EAST consists of four gyrotrons with a frequency of 140 GHz (second harmonic of the extraordinary mode), each of which is expected to deliver a maximum power of 1.0 MW and be operated at 100-1000 s pulse length. Significant progress in long-pulse operation has been achieved recently, including the pulse duration up to 1056 s with EC power injected into plasma of 0.55 MW and the pulse duration of 310 s with EC power of 1.6 MW (output by 3 gyrotrons). High electron temperature (Te >12 keV) plasma measured by Thomson scattering was produced with the combination of EC and lower hybrid (LH) waves. It is found that the plasma heating effect depends on the EC power location greatly. By adjusting the EC power location, the plasma current profile can be modified. As a consequence of the increment of electron temperature by electron cyclotron resonance heating (ECRH), the lower hybrid current drive (LHCD) efficiency is improved, benefiting for the long-pulse operation. In addition, a synergy effect between EC and LH current drive was observed in steady-state operation on EAST.
Simulation and reflectivity measurements of the ITER first plasma beam dump material
Authors: Hentrich Andreas
Published: February 2023

When constructing a beam dump for a fusion device, one faces several challenges and constrictions: It must be vacuum compatible, resistant to temperatures and radiation, should neither gas out nor deteriorate, should take up as less space as possible and obviously also should absorb microwave radiation well. As possible candidates, the group of ceramic metal oxide layers have been suggested, from which three different material systems have been produced by atmospheric plasma spraying and investigated: Titanium oxide, chromium oxide and an aluminum-titanium oxide compound material. Both pure titanium oxide and chromium oxide don’t show the absorption necessary, but Al2O3/TiO2 (60/40) is very promising and will be presented in the following.
Design of Stray Radiation Sensor for ITER ECE Diagnostic
Authors: Danani S. , Punia Sheetal , Kumar Ravinder , Pandya Hitesh Kumar B. , Kumar Vinay
Published: February 2023

The Electron Cyclotron Emission (ECE) diagnostic has a primary role in the measurement of electron temperature profile and electron temperature fluctuations in ITER. This diagnostic shall be exposed to significant power due to unabsorbed Electron Cyclotron Heating (ECH) power in the plasma. The expected stray power loads could be a few tens of watts, and therefore, the protection of millimetre wave components is one of the design challenges of ITER ECE diagnostic. This protection system includes sensors, a band stop notch filter, and a shutter to stop the RF stray radiation from being incident on the sensitive components. The sensors will be positioned along the ECE transmission line, and shall be used for real-time power monitoring of the stray radiation. Here, we describe a novel design of a sensor for monitoring the stray radiation power. This sensor is a Schottky Diode rectenna, known for high-power and high-speed millimetre wave detection capability. It consists of a 2x2 microstrip patch antenna array, a matching circuit, a diode, and a low pass filter. The antenna array is designed analytically and optimized in CST Microwave Studio, for wide reception angle, high gain, and low side lobe levels. Furthermore, the rectifying circuit is optimized using Agilent Advanced Design System (ADS) software to get better rectification and impedance matching of the signal, thereby improving its detection sensitivity. The ADS simulation results show that the detection sensitivity is about 1000V/W for input power of -30 dBm at 170 GHz, thereby achieving the required performance of the sensor.
ITER ECH&CD Control System: Architecture, interfaces and status of development
Authors: Carannante Giuseppe , Cavinato Mario , Cindric Katarina , De Vries Peter , Felici Federico , Ferrari Martino Giordano , Ferrò Giuseppe , Henderson Mark , Neto André , Preynas Melanie , Reich Matthias , Sartori Filippo , Zabeo Luca
Published: February 2023

The ITER ECH&CD system is designed to inject 20 MW of millimetre-wave at 170 GHz into the vacuum vessel. The system is composed of many sub-systems, namely High-Voltage Power Supplies (HVPS), Gyrotrons, Transmission Lines (TL), Ex-vessel Waveguides (EW), Launchers. It is the role of the EC Plant Controller (ECPC) to integrate all the Sub-system Control Units (SCU), to prepare the system for operation and to execute the real-time requests coming from the plasma control system. The ECPC also implements plant level protection functions involving more than one sub-system and it interfaces with the ITER Central I&C. This paper gives an overview of the EC system and a description of the control system development focusing on the architecture and the interfaces. Control and protection functions are presented together with a functional allocation to better define interfaces and responsibilities. The preliminary design of the interface with the Plasma Control System to implement advanced control functions is also presented.
Gyrotron anode voltage control in EAST ECRH system
Authors: Xu Weiye , Xu Handong , Zhang Jian , Guo Fei , Sun Haozhang
Published: February 2023

Four diode-type gyrotrons are used in the EAST ECRH system now. The anode is one of the main components of the gyrotron. We can control the output power of the gyrotron by changing the anode voltage. An anode voltage control system for ASIPP anode power supplies was developed based on the ethernet CompactDAQ chassis NI-cDAQ-9185. The anode voltage can be controlled up to 30 kV, and the maximum current is 100 mA. The maximum modulation frequency is 5 kHz at a 50% duty cycle.
Research on the space design strategy of college classrooms based on positive emotion and learning happiness experience
Authors: Wu Dan
Published: February 2023

Traditional education mostly guides students’ learning through teachers’ words and deeds, while ignoring the spatial environment of learning is another kind of subtle education. The experiment was conducted with 66 students, 84 class hours, and 5544 action tracking data. Based on environmental psychology theory and teaching practice, this paper proposes a space design strategy for college classrooms to stimulate positive emotions and learning happiness: the Harkness round table model, which stimulates the willingness to communicate, responds to the flexible layout of different teaching situations and the ablation of classroom boundaries.
Identity and Identification in Campus Lore
Authors: Wei Jiachen
Published: February 2023

As a form of modern urban legend, school legends have become a symbol of campus culture and are spread through the internet and orally. These school legends, which are based on some real historical elements and are mixed with a bit of spirituality and spooky atmosphere, are not only entertaining anecdotes for the students and teachers living on campus, but also become an important part of the school culture, contributing to their perception of individual identity and group identity.
Practical Research and Exploration of Literary Literary Works Under Transmedia Narratives
Authors: Yang Zane
Published: February 2023

This article outlines some basic concepts of literature under transmedia narratives as well as criteria for judging literature and suggestions and summaries for future development. It also proposes that the most ideal form of transmedia narrative is one in which each medium excels in its own way, each doing its own job”, combing through a review of domestic and international research. The concepts of transmedia narrative and transmedia communication, transmedia marketing, and adaptation are identified, and the definition of literary works is defined. Finally, by analysing the current status of transmedia narratives, it is pointed out that online works are currently the preferred resource for transmedia narrative attempts. A typical example of a domestic and international online work, Notes from a Tomb Raider, is selected for analysis, and the final section reflects on and offers suggestions for the transmedia narratives of domestic online literary works. The analysis and outlook for the development of online literature in transmedia narratives are provided.
Research on Bilingual Service and External Communication of Red Culture Scenic Spots in Shandong Province
Authors: Lu Qian
Published: February 2023

China has a rich and colorful culture, and the cultural appreciation value and research value are very high. It should be our important responsibility and obligation to help and guide more tourists to learn, understand, appreciate and appreciate China’s profound cultural accumulation. At present, the rapid development of “Internet” information technology and the gradual popularization of intelligent terminals have provided important opportunities and built an effective platform for the external dissemination of cultural tourist attractions and culture, as well as the development of foreign language identification, interpretation and other services. Shandong is not only our country economic province, and the red tourist attractions, red sites, red resources is very rich, Shandong cultural tourism got rapid development in recent years, under the new situation, how to strengthen the red culture in Shandong province give full play to the advantage, strengthen the effective implementation of cultural drive strategy should be an important research topic. 1This study in the Shandong red culture foreign communication significance and value, on the basis of the red culture resources in Shandong province, analyzes the current Shandong red culture tourism attractions bilingual service present situation and the existing problems, provide improvement and optimization of countermeasures and path, to strengthen the development of Shandong red culture, red culture and promote the direction towards the cultural industry resources and development, really make the red culture effectively into real productivity, into economic benefits, better boost the high quality of economic and social development in Shandong province.
A Study on the Strategies for Translating Place Names in Lingnan Folk Tales with the Perspective of Eco-translatology
Authors: Wu Yu-Mei , Wu Yue-Fang
Published: February 2023

Lingnan folk tales reflect the folk customs of the Lingnan region. The places involved in the tales are named in various ways, either reflecting the geographical location, or reflecting the people’s livelihood. Taking the differences in language and culture between Chinese and English into consideration, this paper analyzes the eco-translatology theory and several general strategies for translating the place names in China into English before applying the framework constructed by the language dimension, the culture dimension and the communication dimension from the perspective of eco-translatology to translate the place names in Lingnan folk tales. The cases in point show that the translation methods such as direct translation, free translation, and annotation can be applied according to the specific cultural context and the communicative intention in the folk tales with the ultimate goal to let the translation survive effectively in the translation ecology of the target language, spread the culture in the source text and make readers of the target language arouse the same feeling brought by the source text.
The Application of Traditional Chinese Cultural Elements in Fantasy Costume Drama - A Case Study of “Love Between Fairy and Devil”
Authors: Li Ruijun
Published: February 2023

The spread of Chinese TV dramas cannot be separated from the strong underpinnings of Chinese stories. Strengthening the multifaceted presentation of traditional culture is an indispensable element in creating quality TV dramas with culture, connotation and Chinese characteristics. With a unique oriental narrative and a unique oriental romantic audio-visual language, the fantasy ancient idol drama “Love Between Fairy and Devil” restores a beautiful oriental fantasy world, which helps to reshape the audience’s visual imagination of Chinese classical mythology, conveys the unique charm of Chinese traditional culture to the audience, and promotes the further “going out” of traditional culture.
Analysis of Aesthetic Homogeneity Based on the Theory of The Society of the Spectacle — Taking Xiaohongshu as an Example
Authors: Qiu Qing
Published: February 2023

Nowadays, people always pursue the trend of the popular new things and thus gradually have similar aesthetics to others, resulting in the homogeneity of people’s aesthetics. For example, Xiaohongshu provides contemporary young women with aesthetic guidelines on life and cosmetics. Users of Xiaohongshu are also willing to accept and imitate such an aesthetic style. In addition, in the process of communication, it built a false spectacle. The algorithm mechanism of big data and the KOL role of bloggers make the contents of Xiaohongshu in the spectacle similar, resulting in the homogeneity of aesthetic contents. To research whether Xiaohongshu has aesthetic homogeneity, by using the content analysis method, this study analyzes whether the content of Xiaohongshu has aesthetic homogeneity. The study finds that Xiaohongshu has aesthetic homogeneity in the aesthetic keywords and types and then discusses the reasons for homogeneity.
Analysis of Tea Material Culture in China and Britain
Authors: Gao Yijie , Li Yajun
Published: February 2023

China is the first country in the world to grow, make and taste tea, and has a colorful tea culture. After absorbing some of the connotations of Chinese tea culture, the United Kingdom, through innovation and integration, has condensed a unique British tea culture. The two countries that both have tea have very different tea situations. This paper focuses on comparing the differences between the two countries at the level of the material culture in tea culture and exploring the reasons behind the differences.
An investigation into the causes of science fiction animation influencing young people’s awareness of science and technology based on the DIMT model - Love, Death and Robots as an example
Authors: Liu Xinrui , Yang Jiawen , Zhao Xinran
Published: February 2023

As a medium, science fiction animation has a special significance for the construction of science and technology awareness among youth. As the science fiction animation market is booming and popular among young people, it is more and more urgent to explore ways to improve the impact of science fiction animation. This research report analyzes the science fiction symbolic landscape presented by the animation through the questionnaire analysis and interviews of Love, Death and Robots, and explores the meaning construction of the science fiction symbols in the animation and the dissemination path of the scientific spirit kernel, in order to explore the law of its construction of science and technology consciousness for young people, with a view to providing some reference for the innovative development of science fiction animation in China in the future.
Innovative Application of Traditional Chinese Cultural Symbols in Contemporary Architecture
Authors: Liu Qiang , Shi Nan
Published: February 2023

Traditional Chinese culture, with its distinctive nationality and regionalism, is a valuable source of creative elements for Chinese architecture, and also an effective weapon to cope with the impact of “internationalization” and “standardization”. In this paper, traditional cultural elements are symbolically categorized, dissected and innovated through architectural semiotics to explore the characteristics and application significance of traditional cultural symbols in contemporary architectural design. Moreover, case studies are conducted to derive the correct expression of traditional Chinese culture in contemporary architectural design, with a view to finding out a universal path for applying traditional cultural symbols in architecture.
Research on Innovation Strategy of Enterprise Operation and Management in Digital Economy Era
Authors: Yang Li , Peng Huang , Mengni Zhou , Juanatas Ronaldo , Niguidula Jasmin , Huiliang Huang
Published: February 2023

At present, due to the vigorous development of digital economy, enterprises need to follow the pace of social development to speed up the transformation and development of enterprises, optimize and adjust the company’s daily operation and management by innovation, adapt to the current social changes, and strive to avoid the hidden crisis in the development of enterprise operation. The author fully discusses the company’s operation and management under the trend of digital management, and provides helpful ideas for the company’s future development and research management.
Behandlung von persistierenden Lungenparenchymverletzungen beim Thoraxtrauma: Lungenlazeration, pleurale Fistel und Pneumothorax
Authors: Neudecker Jens , Schulz-Drost Stefan , Walles Thorsten
Published: February 2023

Das Thoraxtrauma ist eine häufige Unfallverletzung mit hoher Morbidität und Mortalität. Die präklinische und klinische Akutversorgung des Thoraxtraumas erfolgt entsprechend den Empfehlungen
einer nationalen S3-Leitlinie. Nach erfolgreicher Akutversorgung können bei bis zu einem Drittel der Patienten Lungenlazerationen, pleurale Fisteln und Pneumothoraces als Folgezustände
persistieren. In einer interdisziplinären Arbeitsgruppe der Deutschen Gesellschaft für Thoraxchirurgie und der Deutschen Gesellschaft für Unfallchirurgie wurde die vorhandene klinische
Evidenz zur Behandlung dieser Verletzungen gesichtet, bewertet und in Form von Konsensusempfehlungen ausgearbeitet. Hierbei zeigte sich eine inkohärente Klassifikation der Verletzungsfolgen
und eine geringe Evidenz für Diagnose- und Therapieempfehlungen zur Behandlung dieser Folgezustände.
Spontaneous Intracranial Hypotension Due to CSF Leak at Multiple Spinal Levels—A Case Report and Literature Review
Authors: Saranraj M.K. , Giridharan K. , Nathan Sudhakshina , Babu Nadasha M. , Balamurugan Mangaleswaran
Published: February 2023

Introduction Spontaneous intracranial hypotension (SIH) is a misdiagnosed condition characterized by low cerebrospinal fluid (CSF) volume and an orthostatic headache that worsens with upright posture due to CSF leak at spinal dural defects. SIH due to CSF leak at multiple spinal levels is a rare condition, and only a few cases have been reported in the literature. Here, we report a case of SIH with a CSF leak at multiple spinal levels. The treatment options and efficacy of epidural blood patch (EBP) injection were discussed in this article.

Case Report A 36-year-old man presented with complaints of orthostatic headache for 2 months and a computed tomography myelogram demonstrated CSF leaks at multiple spinal levels through the dural defects at C5-C6, C6-C7, C7-T1, T1-T2 levels, and at L1, L2, L3, and L4 vertebral levels on the left side. He was managed with a targeted EBP injection and he improved symptomatically within 24 hours of the EBP injection.

Summary SIH is an entity that results from CSF leakage, often through spinal dural defects due to mechanical tear by osteophyte complex, disc prolapse, connective tissue disorders, CSF-venous fistula, and leaking meningeal diverticula. SIH can result from single or multiple dural leaks, but spinal leaks at multiple levels are uncommon. To the best of our knowledge, a total number of 163 cases have been reported in the literature so far. With good success rates, targeted EBP injection with autologous blood is an effective treatment option for both single-level and multiple-level spinal leaks.
An improved composition design method for high-performance copper alloys based on various machine learning models
Authors: Zhao Siyue , Li Na , Hai Guangtong , Zhang Zhigang
Published: February 2023

The preparation of high-performance copper alloys generally considers alloying approaches to solve the conflicting problems of high strength and high electrical conductivity. The traditional “trial and error” research model is complicated and time-consuming. With the continuous accumulation of material databases and the advent of the “big data” era, machine learning has rapidly become a powerful tool for material design and development. In this paper, a total of 407 copper alloy data were collected. In the multi-objective prediction problem, the many-to-many prediction using back propagation neural network alone is improved to a many-to-one prediction. This improvement is based on back propagation neural network, tree model and support vector machine model. Through comparative analysis, an improved composition to property model was developed to predict the tensile strength and electrical conductivity of copper alloys, and the overall coefficient of determination reached 0.98; an improved property to composition model was developed to predict the composition of copper alloys, and the overall coefficient of determination reached 0.78. By combining these two models and the particle swarm optimization algorithm, an improved machine learning design system (MLDS) model was developed to achieve the composition prediction of copper alloy. The overall coefficient of determination reached 0.87, the prediction effect was better than the original MLDS model and with stronger stability. This method is of guiding significance for the alloy composition design of high-performance copper alloys. In addition, it also has certain reference value for the alloy composition design of other alloys.
Effect of Te content on microstructure and thermoelectric properties of Bi–Te multilayers
Authors: Zhang Jianxin , Jia Xuan , Yan Huifen , Xiao Ningru , Ning Pingfan , Yu Liyuan , Li Yuqiang
Published: February 2023

Bi2Te3 is a thermoelectric material with high thermoelectric conversion efficiency near room temperature. The control of its components is an effective method to improve the thermoelectric properties of Bi–Te based materials. In this paper, seven-layer Bi–Te thin films with Te content ranging from 36.29% to 77.29% were deposited on non-rotating glass substrates by co-sputtering and the samples were rapidly thermally annealed in a nitrogen atmosphere. The films were characterized by x-ray diffraction, scanning electron microscopy, and Hall effect measurement methods, and the effects of the components on the film morphology and thermoelectric properties were investigated. The results showed that the films were composed of mainly Bi2Te3 after annealing. As the Te element content increased, the grain size in the film surface first increased and then decreased, the layers between the interfaces became less obvious, and the number of voids decreased. Subsequently, thin films with Te content between 60% and 75% were deposited on a rotating substrate; the thermoelectric properties were relatively high and stable after annealing. A film with Te content of 69.29% had a good crystallization quality and large grain size with a maximum power factor of 8.17 µW/(K2 cm) after annealing at 350 °C for 17 min.
Enhancing the electron mobility in Si-doped (010) β-Ga2O3 films with low-temperature buffer layers
Authors: Bhattacharyya Arkka , Peterson Carl , Itoh Takeki , Roy Saurav , Cooke Jacqueline , Rebollo Steve , Ranga Praneeth , Sensale-Rodriguez Berardi , Krishnamoorthy Sriram
Published: February 2023

We demonstrate a new substrate cleaning and buffer growth scheme in β-Ga2O3 epitaxial thin films using metal–organic vapor phase epitaxy (MOVPE). For the channel structure, a low-temperature (LT, 600 °C) un-doped Ga2O3 buffer was grown, followed by a transition layer to a high-temperature (HT, 810 °C) Si-doped Ga2O3 channel layers without growth interruption. The (010) Ga2O3 Fe-doped substrate cleaning uses solvent cleaning, followed by additional hydrofluoric acid (49% in water) treatment for 30 min before the epilayer growth. This step is shown to compensate the parasitic Si channel at the epilayer–substrate interface that originates from the substrate polishing process or contamination from the ambient. From secondary ion mass spectroscopy (SIMS) analysis, the Si peak atomic density at the substrate interface is found to be several times lower than the Fe atomic density in the substrate—indicating full compensation. The elimination of the parasitic electron channel at the epi–substrate interface was also verified by electrical (capacitance–voltage profiling) measurements. In the LT-grown (600 °C) buffer layers, it is seen that the Fe forward decay tail from the substrate is very sharp, with a decay rate of ∼9 nm/dec. X-ray off-axis rocking curve ω-scans show very narrow full width at half maximum (FWHM) values, similar to the as-received substrates. These channels show record high electron mobility in the range of 196–85 cm2/V⋅s in unintentionally doped and Si-doped films in the doping range of 2 × 1016–1 × 1020 cm−3. Si delta-doped channels were also grown utilizing this substrate cleaning and the hybrid LT buffers. Record high electron Hall mobility of 110 cm2/V⋅s was measured for sheet charge density of 9.2 × 1012 cm−2. This substrate cleaning, combined with the LT buffer scheme, shows the potential of designing Si-doped β-Ga2O3 channels with exceptional transport properties for high-performance Ga2O3-based electron devices.
Torque and magnetic suspension force generation in dual armature alternating pole bearingless flux reverse permanent magnet machine
Authors: Yang Yifei , Li ChengDong , Jiang GuanJiang , Liu Jie
Published: February 2023

Dual-armature alternating pole bearingless flux reversal permanent magnet (DAAPBFR) machines have the characteristics of high speed and non-contact operation; they are suitable for aerospace, flywheel battery, and other wide speed-range applications. Based on the analysis of the mechanism of torque and suspension force, the power dimension equation of the machine is given, which lays the foundation for the design of structural parameters. Finally, the influences of torque output capacity and radial suspension force of the machine are estimated, and the relationship between air gap magnetic density, copper loss, and torque is examined. The simulation shows that the DAAPBFR machine has good overload capacity.
Drastic enhancement of the superconducting temperature in type-II Weyl semimetal candidate MoTe2 via biaxial strain
Authors: Yip King Yau , Lam Siu Tung , Yu Kai Ham , Chow Wing Shing , Zeng Jiayu , Lai Kwing To , Goh Swee K.
Published: February 2023

A type-II Weyl semimetal candidate MoTe2, which superconducts at Tc ∼0.1 K, is one of the promising candidates for realizing topological superconductivity. However, the exceedingly low Tc is associated with a small upper critical field (Hc2), implying a fragile superconducting phase that only exists on a small region of the H–T phase diagram. Here, we describe a simple and versatile approach based on the differential thermal expansion between dissimilar materials to subject a thin single crystalline MoTe2 to biaxial strain. With this approach, we successfully enhance the Tc of MoTe2 by fivefold and consequently expand the superconducting region on the H–T phase diagram significantly. To demonstrate the relative ease of studying the superconductivity in the biaxially strained MoTe2, we further present the magnetotransport data, enabling the study of the temperature-dependent Hc2 and the anisotropy of the superconducting state, which would otherwise be difficult to obtain in a free-standing MoTe2. Our work shows that biaxial strain is an effective knob to tune the electronic properties of MoTe2. Due to the simplicity of our methodology to apply biaxial strain, we anticipate its direct applicability to a wider class of quantum materials.
Scaling of the morphology of African cities
Authors: Prieto-Curiel Rafael , Patino Jorge E. , Anderson Brilé
Published: February 2023

A large proportion of Africa’s infrastructure is yet to be built. Where and how these new buildings are constructed matters since today’s decisions will last for decades. The resulting morphology of cities has lasting implications for a city’s energy needs. Estimating and projecting these needs has always been challenging in Africa due to the lack of data. Yet, given the sweeping urbanization expected in Africa over the next three decades, this obstacle must be overcome to guide cities toward a trajectory of sustainability and resilience. Based on the location and surface of nearly 200 million buildings on the continent, we estimate the interbuilding distance of almost six thousand cities. Buildings’ footprint data enable the construction of urban form indicators to compare African cities’ elongation, sprawl, and emptiness. We establish the BASE model, where the mean distance between buildings is a functional relation to the number of Buildings and their average Area, as well as the Sprawl and the Elongation of its spatial arrangement. The mean distance between structures in cities—our proxy for its energy demands related to mobility—grows faster than the square root of its population, resulting from the combined impact of a sublinear growth in the number of buildings and a sublinear increase in building size and sprawl. We estimate that when a city doubles its population, it triples its energy demand from transport.