bluuebunny/crossref_metadata_2025 huggingface dataset:
Adherence to pancreatic enzyme replacement therapy among patients with chronic pancreatitis in East China: a mixed methods study
Authors: Zhou You , Huang Ren-Qian , Wu Qi-Wei , Xu Jin-Jie , Yi Jin-Hui , Chen Cui , Lu Guo-Tao , Li Zhao-Shen , Wang Dan , Hu Liang-Hao
Published: October 2023

Pancreatic enzyme replacement therapy (PERT) has been recommended as the preferred method for pancreatic exocrine insufficiency caused by chronic pancreatitis (CP). However, at present, the patient-related factors for the poor PERT management are not clear, and there are no studies on the adherence to PERT in patients with CP in East China. This was a mixed-method study following the principle of sequential explanatory design and included two parts: a quantitative and qualitative study. A cross-sectional survey of medication adherence (MA) was first carried out, followed by a semi-structured interview to further explore and explain the influencing factors of adherence to PERT. Of the 148 patients included in this study, 48.0% had poor MA and only 12.8% had good MA. Multivariate logistic regression showed that lower levels of education and income were contributing factors for non-adherence to PERT. Semi-structured interviews with 24 patients revealed that the reasons for non-adherence also included lack of knowledge, self-adjustment of PERT, lifetime of medication, side effects of PERT, forgetfulness, financial burdens, and accessibility issues. The adherence to PERT was poor among patients with CP in East China. Healthcare providers should personalize medication strategies to improve patients’ MA.
Neanderthal introgression in SCN9A impacts mechanical pain sensitivity
Authors: Faux Pierre , Ding Li , Ramirez-Aristeguieta Luis Miguel , Chacón-Duque J. Camilo , Comini Maddalena , Mendoza-Revilla Javier , Fuentes-Guajardo Macarena , Jaramillo Claudia , Arias William , Hurtado Malena , Villegas Valeria , Granja Vanessa , Barquera Rodrigo , Everardo-Martínez Paola , Quinto-Sánchez Mirsha , Gómez-Valdés Jorge , Villamil-Ramírez Hugo , Silva de Cerqueira Caio C. , Hünemeier Tábita , Ramallo Virginia , Gonzalez-José Rolando , Schüler-Faccini Lavinia , Bortolini Maria-Cátira , Acuña-Alonzo Victor , Canizales-Quinteros Samuel , Poletti Giovanni , Gallo Carla , Rothhammer Francisco , Rojas Winston , Schmid Annina B. , Adhikari Kaustubh , Bennett David L. , Ruiz-Linares Andrés
Published: October 2023

The Nav1.7 voltage-gated sodium channel plays a key role in nociception. Three functional variants in theSCN9Agene (encoding M932L, V991L, and D1908G in Nav1.7), have recently been identified as stemming from Neanderthal introgression and to associate with pain symptomatology in UK BioBank data. In 1000 genomes data, these variants are absent in Europeans but common in Latin Americans. Analysing high-density genotype data from 7594 Latin Americans, we characterized Neanderthal introgression inSCN9A. We find that tracts of introgression occur on a Native American genomic background, have an average length of ~123 kb and overlap the M932L, V991L, and D1908G coding positions. Furthermore, we measured experimentally six pain thresholds in 1623 healthy Colombians. We found that Neanderthal ancestry inSCN9Ais significantly associated with a lower mechanical pain threshold after sensitization with mustard oil and evidence of additivity of effects across Nav1.7 variants. Our findings support the reported association of Neanderthal Nav1.7 variants with clinical pain, define a specific sensory modality affected by archaic introgression inSCN9Aand are consistent with independent effects of the Neanderthal variants on Nav1.7 function.
Dendritic deformation modes in additive manufacturing revealed by operando x-ray diffraction
Authors: Dass Adrita , Tian Chenxi , Pagan Darren C. , Moridi Atieh
Published: October 2023

Dynamic solidification behavior during metal additive manufacturing directly influences the as-built microstructure, defects, and mechanical properties of printed parts. How the formation of these features is driven by temperature variation (e.g., thermal gradient magnitude and solidification front velocity) has been studied extensively in metal additive manufacturing, with synchrotron x-ray imaging becoming a critical tool to monitor these processes. Here, we extend these efforts to monitoring full thermomechanical deformation during solidification through the use of operando x-ray diffraction during laser melting. With operando diffraction, we analyze thermomechanical deformation modes such as torsion, bending, fragmentation, assimilation, oscillation, and interdendritic growth. Understanding such phenomena can aid the optimization of printing strategies to obtain specific microstructural features, including localized misorientations, dislocation substructure, and grain boundary character. The interpretation of operando diffraction results is supported by post-mortem electron backscatter diffraction analyses.
Irreversible loss in marine ecosystem habitability after a temperature overshoot
Authors: Santana-Falcón Yeray , Yamamoto Akitomo , Lenton Andrew , Jones Chris D. , Burger Friedrich A. , John Jasmin G. , Tjiputra Jerry , Schwinger Jörg , Kawamiya Michio , Frölicher Thomas L. , Ziehn Tilo , Séférian Roland
Published: October 2023

Anthropogenic warming of the oceans and associated deoxygenation are altering marine ecosystems. Current knowledge suggests these changes may be reversible on a centennial timescale at the ocean surface but irreversible at deeper depths even if global warming were to ameliorate. In contrast, the marine ecosystem’s response to these persistent changes remains poorly elucidated. Here we explore to what extent global warming may drive alterations in marine habitats by exploring the evolution of a metabolic index that captures marine organisms’ ecophysiological response to both temperature and oxygen changes, throughout an idealised ramp-up/ramp-down atmospheric carbon dioxide concentration and an overshoot scenarios. Using a multi-model approach; we find that changes in ocean temperature and oxygen drive a centuries-long irreversible loss in the habitable volume of the upper 1000 m of the world ocean. These results suggest that the combined effect of warming and deoxygenation will have profound and long-lasting impacts on the viability of marine ecosystems, well after global temperatures have peaked.
High-throughput bacterial co-encapsulation in microfluidic gel beads for discovery of antibiotic-producing strains
Authors: Ochoa Abraham , Gastélum Gabriela , Rocha Jorge , Olguin Luis F.
Published: October 2023

A simplified microfluidic high-throughput methodology coupled with Fluorescence Activated Cell Sorting (FACS) is used to screen, sort and recover antibiotic-producing bacterial strains.
Regulating the stereoselectivity of medium-chain dehydrogenase/reductase by creating an additional active pocket accommodating prochiral heterocyclic ketones
Authors: Qin Lei , Su Xin , Wang Jun , Wu Lunjie , Zou Man , Gu Jie , Xu Yan , Nie Yao
Published: October 2023

The stereoselectivity of MDR was regulated by creating an active pocket suitable for substrate localisation. Enantioselective complementary reduction of a series of heterocyclic ketones was achieved with high catalytic activity and stereoselectivity.
Exploring the non-monotonic DNA capture behavior in a charged graphene nanopore
Authors: Yu You-Sheng , Ren Qiang , Tan Rong-Ri , Ding Hong-Ming
Published: October 2023

By using all-atom molecular dynamics simulation, we observe that the relationship between the DNA capture rate and the amount of positive charge on the graphene nanopore is non-monotonic.
Nonvolatile magnetoelectric coupling in two-dimensional van der Waals sandwich heterostructure CuInP2S6/MnCl3/CuInP2S6
Authors: Wang Zichun , Pan Honggang , Zhou Baozeng
Published: October 2023

A model of an atom-thick memory based on a CuInP2S6/MnCl3/CuInP2S6 multiferroic heterostructure. Nonvolatile modulation of the electronic properties in DHM MnCl3 can be achieved through magnetoelectric coupling with the FE CuInP2S6 layer.
Unveiling the intersystem crossing dynamics in N-annulated perylene bisimides
Authors: Sunny Jeswin , Sebastian Ebin , Sujilkumar Suvarna , Würthner Frank , Engels Bernd , Hariharan Mahesh
Published: October 2023

We present nitrogen annulation as a strategy to populate triplet excited states in perylene bisimide. The triplet quantum yield can be further enhanced by single bromine substitution on the nitrogen-annulated perylene bisimide.
Plasma synthesis of oxygen vacancy-rich CuO/Cu2(OH)3NO3 heterostructure nanosheets for boosting degradation performance
Authors: Yang Zikun , Peng Xiangfeng , Zheng Jingxuan , Wang Zhao
Published: October 2023

CuO/Cu2(OH)3NO3 heterostructure nanosheets were synthesized via DBD plasma-assisted nitrogen fixation. The synergistic effect of oxygen vacancies and heterojunction interfaces enhances the degradation performance.
Enhanced sensing performance of armchair stanene nanoribbons for lung cancer early detection using an electric field
Authors: Mashhadbani Maedeh , Faizabadi Edris
Published: October 2023

The applied electric field modifies the electronic properties of the lung cancer detection sensor. The sensing characteristics of the armchair stanene nanoribbon are either enhanced or weakened depending on the direction of the electric field.
Hydrogen-bonded organic frameworks: new horizons in biomedical applications
Authors: Yu Dongqin , Zhang Haochen , Ren Jinsong , Qu Xiaogang
Published: October 2023

Hydrogen-bonded organic frameworks (HOFs) are an emerging attractive class of highly crystalline porous materials characterized by significant biocompatibility, rich chemical functionalities and well-defined porosity.
Developing electrochemical hydrogenation towards industrial application
Authors: Kleinhaus Julian T. , Wolf Jonas , Pellumbi Kevinjeorjios , Wickert Leon , Viswanathan Sangita C. , junge Puring Kai , Siegmund Daniel , Apfel Ulf-Peter
Published: October 2023

Electrochemical hydrogenation reactions hold the promise of more sustainable production routes for towards bulk and fine chemicals. Their broad applicability, reactor concepts, achieved milestones and future perspectives are described herein.
Towards catalytic redox-active iridium polypyridyl complex by in situ photosubstitution
Authors: Tan Yi Zhen , Wu Xiangyang , Lu Yunpeng , Chiba Shunsuke , Yeow Edwin K. L.
Published: October 2023

In situ modification of an Ir(iii) complex generates catalytic redox-active species that are used to facilitate hydrodehalogenation reactions.
A topochemical reaction induced the formation of Bi2S3 micro-straws from a Bi-MOF for an ultra-long Zn storage life
Authors: Gou Lei , Liang Kai , Wang Wen-Yan , Lei Ya-Ting , Xie Shou-Lin , Wei Ding-Kai , Li Dong-Lin , Fan Xiao-Yong
Published: October 2023

The Bi2S3 micro-straws is created by a topochemical reaction using Bi-PYDC template and the formation mechanism is investigated. Zn || Bi2S3-TH cell delivers high specific capacities of 153.4 mAh g−1 at 1 A g−1 after more than 10000 cycles.
Structure–activity effects in the anti-leishmanial activity of di-alkyl gallium quinolin-8-olates
Authors: Duffin Rebekah N. , Andrews Philip C.
Published: October 2023

The anti-Leishmanial activity and cytotoxicity of novel alkyl gallium quinoline-8-olates [Ga(R)2quin] (R = Et, nBu, sBu, tBu, iPr, hex) have been assessed, with the nBu complex found to exhibit a high degree of activity and selectivity.
Decoding the puzzle: recent breakthroughs in understanding degradation mechanisms of Li-ion batteries
Authors: Singh Aditya Narayan , Hassan Kamrul , Bathula Chinna , Nam Kyung-Wan
Published: October 2023

This review examines Li-ion battery degradation, with a focus on the cathode-electrolyte interphase (CEI), modification, modeling, and novel characterization tools for improved battery performance.
Terbium-induced cobalt valence-band narrowing boosts electrocatalytic oxygen reduction
Authors: Wang Xuan , Zhang Juan , Wang Pu , Li Liangcheng , Wang Huiyu , Sun Dongmei , Li Yafei , Tang Yawen , Lu Xue Feng , Wang Yu , Fu Gengtao
Published: October 2023

Tb2O3 endows Co 3d with a narrow band and appropriate band location via Co 3d–O 2p–Tb 4f gradient orbital coupling to efficiently enhance the oxygen reduction reaction.
Construction of isolated Co–Nx and dual Con–CoNx sites for the regulation of hydrogenation and hydrodeoxygenation selectivity of biomass-derived chemicals
Authors: Xia Zhanghui , Niu Libo , Wu Qi , An Yadan , Bai Guoyi
Published: October 2023

This work provide a new strategy to develop efficient catalysts for the CO hydrogenation and C–O cleavage of biomass chemicals.
Room-temperature tandem conversion of cyclic alkenes into 1,2-diols using molecular oxygen and β-MnO2heterogeneous catalyst
Authors: Su Shihao , Lv Guojun , Zou Xuyang , Wang Jiangzhang , Zhou Chaoyi , Chen Yan , Shen Jialing , Shen Yangbin , Liu Zhongmin
Published: October 2023

Tandem conversion of cyclohexene into 1,2-cycloheanediol was attained by applying the generated by-product carboxylic acid as catalyst 2, realizing the effective utilization of isobutyric acid, shortening reaction time, and saving energy consumption.
Light-induced aryldifluoromethyl-sulfonylation/thioetherification of alkenes using arenethiolates as a photoreductant and sulfur source
Authors: Li Jiayu , Guo Zipeng , Zhang Xiaofeng , Meng Xiaoli , Dai Zhenyang , Gao Meiyun , Guo Shuo , Tang Pingping
Published: October 2023

A novel ATRA reaction was developed from simple and widely accessible alkenes, thiols, and trifluoromethylarenes vis photo-induced EDA complex strategy. Several complicated bioactive molecules undergo smoothly the one-pot photosynthetic process.
High throughput laser ablation ICP-MS bioimaging of silver distribution in animal organisms and plant tissue after exposure to silver sulfide nanoparticles
Authors: Marolt Gregor , Novak Sara , Kokalj Anita Jemec , Talaber Iva , Kononenko Veno , Loureiro Susana , Khodaparast Zahra , Silva Patrícia V. , Fité Martí Busquets , Handy Richard D. , Drobne Damjana
Published: October 2023

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is a method with high potential to visualize the distribution of elements in different samples, including a variety of organisms.
Effect of repeated irradiation on laser-induced breakdown spectroscopy of copper immersed in a sodium chloride aqueous solution and normalization with bubble collapse time
Authors: Matsumoto Ayumu , Shimazu Yusuke , Yae Shinji , Sakka Tetsuo
Published: October 2023

Strong correlations were found between underwater LIBS signals and bubble collapse time. Signal fluctuation caused by the repeated irradiation at a fixed position was successfully reduced by the normalization with bubble collapse time.
Lewis acidic deep eutectic solvents as catalysts for rosin polymerization
Authors: Yu Yali , Yu Fengli , Li Lu , Yuan Bing , Xie Congxia , Yu Shitao
Published: October 2023

A green and effective catalytic system for rosin polymerization using a recyclable Lewis acidic DES catalyst has been developed.
Evidence of Cytolysin A nanopore incorporation in mammalian cells assessed by a graphical user interface
Authors: Lucas Florian Leonardus Rudolfus , Finol-Urdaneta Rocio K. , Van Thillo Toon , McArthur Jeffrey R. , van der Heide Nieck Jordy , Maglia Giovanni , Dedecker Peter , Strauss Olaf , Wloka Carsten
Published: October 2023

Novel technologies for high precision and temporal resolution of cellular metabolites.
Unlocking the catalytic potential of nickel sulfide for sugar electrolysis: green hydrogen generation from kitchen feedstock
Authors: Patil Supriya A. , Khot Atul C. , Kadam Kalyani D. , Bui Hoa Thi , Im Hyunsik , Shrestha Nabeen K.
Published: October 2023

The first-ever demonstration of Ni7S6/NF-based electrolyzer with sugar or orange-juice as active electrolyte for an alternative anodic oxidation reaction in water-electrolysis and achieving a higher rate of green-hydrogen at a lower cell voltage.
Achieving broadband ultraviolet to mid-infrared transparency in germanate-based nonlinear optical crystals Cs3REGe3O9 (RE = Y, Gd)
Authors: Jiao Jinmiao , Li Conggang , She Yuheng , Ye Ning , Hu Zhanggui , Wu Yicheng
Published: October 2023

Two novel Cs3REGe3O9 (RE = Y, Gd) crystals were extracted and exhibit a breakthrough of UV cutoff edge at 210 and 215 nm, respectively, the shortest value among boron-free germanate-based NLO materials.
Photo-hydroacylation: 1-tetralones from ortho-allylbenzaldehydes
Authors: Schmalz Veronika , Koert Ulrich
Published: October 2023

A novel photoreaction channel can be used to convert ortho-allylbenzaldehydes into 1-tetralones. The proposed mechanistic pathway involves a light-induced 1,5-hydrogen atom transfer (1,5-HAT) and a radical recombination process.
The effect of cetyltrimethylammonium bromide (CTAB) addition on green synthesis of porous N-doped TiO2 for photoreduction of heavy metal ion Cr(vi)
Authors: Wellia Diana Vanda , Syafawi Atika , Putri Yulia Eka , Muldarisnur
Published: October 2023

The synthesis of porous N-doped TiO2 using cetyltrimethylammonium bromide (CTAB) as pore-forming agent for photoreduction of Cr(vi) ions.
Theoretical insights into the structural, optoelectronic, thermoelectric, and thermodynamic behavior of novel quaternary LiZrCoX (X = Ge, Sn) compounds based on first-principles study
Authors: Kumari Meena , Abraham Jisha Annie , Sharma Ramesh , Behera Debidatta , Mukherjee S. K. , Salah Mostafa M. , Al-Anazy Murefah mana , Alqahtani Mohammed S.
Published: October 2023

Quaternary LiZrCoX (X = Ge, Sn) Heusler compounds are assessed for their structural, magnetic, electrical, elastic, vibrational, optical, thermodynamic, and thermoelectric properties. The strong power factor and figure of merit values demonstrate good thermoelectric behaviour.
Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors
Authors: Khan Jadoon Muhammad Siraj , Pelletier Julie , Sévigny Jean , Iqbal Jamshed
Published: October 2023

Indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors.
Recent advances in synthesis and characterization of iron–nickel bimetallic nanoparticles and their applications as photo-catalyst and fuel additive
Authors: Jamil Saba , Khan Shanza Rauf , Bibi Shamsa , Jahan Nazish , Mushtaq Nadia , Rafaqat Faisal , Khan Rais Ahmad , Gill Waqas Amber , Janjua Muhammad Ramzan Saeed Ashraf
Published: October 2023

Cubic structure of Fe/Ni bimetallic nanoparticles for their applications as catalyst and fuel additive.
Synthesis of fungal chitosan–polystyrene modified by nanoparticles of binary metals for the removal of heavy metals from waste aqueous media
Authors: El-Sabbagh Sabha M. , Mira Hamed I. , Desouky Osman A. , Hussien Shimaa S. , Elgohary Dina M. , Ali Anwaar O. , El Naggar Ahmed M. A.
Published: October 2023

Fungal chitosan was extracted (via the biotechnology route) to produce a novel composite for the removal of Cd ions from wastewater. It consists of a chitosan core and nanoparticle-decorated polystyrene shell to conserve chitosan at low pH.
Aryl sulfonate anion stabilized aromatic triangular cation [Pd3]+: syntheses, structures and properties
Authors: Wang Miaomiao , He Zhixin , Chen Meng , Wang Yanlan
Published: October 2023

A series of sulfonate anions paired aromatic triangular palladium clusters 3–7, abbreviated as [Pd3]+[ArSO3]−, were synthesized using a simple “one pot” method, and gave excellent isolated yields (90–95%).
Flame retardancy and wear resistance of epoxy composites modified by whisker-shaped nickel phyllosilicate and microencapsulated ammonium polyphosphate
Authors: Nie Shibin , Zhai Wenli , Xu Yuxuan , He Wei , Yang Jinian
Published: October 2023

Whisker-shaped nickel phyllosilicate (NiPS) was synthesized using nickel-based metal–organic frameworks, and flame retardant and wear-resistant EP composites were prepared by synergizing with microencapsulated ammonium polyphosphate (MFAPP).
Intrinsic half-metallicity in two-dimensional Cr2TeX2 (X = I, Br, Cl) monolayers
Authors: Zhang Jun , He Zixin , Gao Chuchu , Tao Yanyan , Liang Feng , Li Guannan , Gao Benling , Song Guang
Published: October 2023

Two-dimensional (2D) materials with intrinsic half-metallicity at or above room temperature are important in spin nanodevices.
Crafting mono- and novel bis-methylated pyrroloquinoxaline derivatives from a shared precursor and its application in the total synthesis of marinoquinoline A
Authors: Damai Margarita , Guzzardi Norman , Lewis Viliyana , Rao Zenobia X. , Sykes Daniel , Patel Bhaven
Published: October 2023

The synthesis of mono- and bis-methylated pyrrolo[1,2-a]quinoxalines using unstable methyl radicals added to aryl isocyanides is reported, depending on reaction conditions. This approach is used to synthesise marinoquinoline A.
How much is just maths? Investigating problem solving in chemical kinetics at the interface of chemistry and mathematics through the development of an extended mathematical modelling cycle
Authors: Ye Sofie , Elmgren Maja , Jacobsson Magnus , Ho Felix M.
Published: October 2023

Problem solving in chemical kinetics poses substantial challenges for university students since it often involves significant use of mathematics as a tool and language, with challenging translations and transitions between chemical phenomena and mathematical representations. In this paper, we present key findings from a study investigating chemistry students solving tasks centred around the steady-state approximation. Building upon the mathematical modelling cycle (MMC), qualitative analysis of the data collected using a think-aloud protocol led to the development of the extended MMC. This empirically derived extended MMC offers a more detailed account of the processes involved in mathematical modelling of chemical phenomena, highlighting aspects such as the occurrence of deliberation and evaluation throughout the modelling cycle, as well as the varying characteristics, points of activation and roles of extra-mathematical resources during problem solving. We further introduce and use problem-solving trajectories as a tool for visualising and analysing the complex and diverse approaches used by students in their attempts at reaching a solution. Overall, the extended MMC provides a finer-grained model of the cognitive and metacognitive activities that students engage in, offering further insights for research and practice.
Hybrid nanogels by direct mixing of chitosan, tannic acid and magnetite nanoparticles: processes involved in their formation and potential catalytic properties
Authors: Marzini Irranca Santiago , García Schejtman Sergio D. , Rosso Anabella P. , Coronado Eduardo A. , Martinelli Marisa
Published: October 2023

Nanocatalytic nanogels (NCNGs) formed by the crosslinking reaction of functionalized magnetite nanoparticle-tannic acid (MNPs@OTA) with chitosan polymer chains.
Prospects of copper–bismuth chalcogenide absorbers for photovoltaics and photoelectrocatalysis
Authors: Santos Daniely Reis , Shukla Sudhanshu , Vermang Bart
Published: October 2023

The distinct electronic structure of the Cu3BiS3 compound (wittichenite) leads high optical absorption and suitable bandgap, making it promising for photovoltaics and photoelectrochemical applications.
A rare case of iodinated non-fullerene acceptors for high-performance organic solar cells without post-treatments
Authors: Chen Hongbin , Cao Xiangjian , Wang Peiran , Huang Fangfang , Zhang Yunxin , Liang Huazhe , Bi Xingqi , He Tengfei , Feng Wanying , Guo Yaxiao , Ma Zaifei , Long Guankui , Yao Zhaoyang , Kan Bin , Li Chenxi , Wan Xiangjian , Chen Yongsheng
Published: October 2023

Delicate iodization on the phenazine central unit of CH45 was conducted to enhance noncovalent interactions. As a result, a first-class efficiency of 18.15% was achieved by OSCs without any extra post-treatments.
A stress relaxation strategy for preparing high-quality organic–inorganic perovskite thin films via a vapor–solid reaction
Authors: Hu Shenghan , Duan Changyu , Du Hongqiang , Zeng Shuang , Kong Anqi , Chen Yuanyuan , Peng Yong , Cheng Yi-Bing , Ku Zhiliang
Published: October 2023

A post-vapor treatment was developed to alleviate compressive strains in perovskite thin films grown by vapor–solid reaction. Perovskite solar cells based on these films achieved an improved power conversion efficiency of over 22%.
Synchronously enhanced storage stability and adsorption ability of MXene achieved by grafting polyethylenimine
Authors: Li Liang , Shi Xian-ying , Huang Ting , Zhang Nan , Wang Yong
Published: October 2023

MXene has great potential to remove contaminants from wastewater due to its abundant active functional groups.
Interfacial modulation to achieve low lattice thermal conductivity and enhanced thermoelectric performance in n-type Mg3(Sb, Bi)2-based materials via graphene and MXene
Authors: Tian Bang-Zhou , Liao Yi-Yan , Xu Fang , Qiu Xiao-Ling , Zhang Fu-Jie , Ang Ran
Published: October 2023

Interfacial modulation has been considered an effective strategy to enhance the thermoelectric (TE) performance by decoupling thermal and electrical parameters.
Development and application of novel peptide-formulated nanoparticles for treatment of atopic dermatitis
Authors: Lim Chaemin , Lee Subin , Shin Yuseon , Cho Seongmin , Park Chanho , Shin Yungyeong , Song Ee Chan , Kim Wan Ki , Ham Cheolmin , Kim Sang Bum , Kwon Yong-Su , Oh Kyung Taek
Published: October 2023

Pal-RMSP1 peptide is effective in treating atopic dermatitis, and its nano-formulation further enhances its efficacy.
Luteolin-loaded biocomposites containing tantalum and polyimide with antibacterial effects for facilitating osteogenic differentiation and bone bonding
Authors: Wu Zhaoying , Kaewmanee Rames , Yang Qianwen , Wang Zimin , Xie En , Wei Jie , Zhang Chao
Published: October 2023

LUPT40 with antibacterial activity could boost osteoblastic differentiation while inhibiting osteoclastic differentiation in vitro and enhance bone bonding in vivo.
Functional mimicry of sea urchin biomineralization proteins with CaCO3-binding peptides selected by phage display
Authors: Völkle (nee Evgrafov) Elke , Schulz Fabian , Kanold Julia Maxi , Michaelis Monika , Wissel Kerstin , Brümmer Franz , Schenk Anna S. , Ludwigs Sabine , Bill Joachim , Rothenstein Dirk
Published: October 2023

The study demonstrates how bioinspired peptides, selected via phage display, mimic sea urchin proteins, influencing the formation of CaCO3 crystals. Charged peptides play a crucial role in shaping these crystals.
Polymeric engineering of AIEgens for NIR-II fluorescence imaging and detection of abdominal metastases of ovarian cancer in vivo
Authors: Zhou Xiaobo , Zeng Yuhan , Li Shijie , Zhang Ke , Zhao Lingfeng , Li Guo , Wang Qi , Ji Haiwei , Wu Mingmin , Liu Jinxia , Qin Yuling , Feng Wei , Li Fuyou , Wu Li
Published: October 2023

Polymeric engineering of amphiphilic polymers used for NIR-II AIEgens encapsulation affords high-brightness AIEdots with small size and long blood circulation time, allowing improved fluorescence imaging in vivo.
Quinodimethane embedded expanded helicenes and their open-shell diradical dications/dianions
Authors: Jiang Qing , Han Yi , Zou Ya , Chi Chunyan
Published: October 2023

Two new quinodimethane embedded expanded [11]- and [13]helicenes were synthesized, showing a closed-shell quinoidal structure. Their dications and dianions exhibit significant open-shell diradical character with small singlet–triplet energy gaps.
Thermoelectric properties of Pnma and R3m GeS and GeSe
Authors: Zhang Min , Flitcroft Joseph M. , Guillemot Sophie K. , Skelton Jonathan M.
Published: October 2023

A fully ab initio modelling workflow is used to predict the thermoelectric figure of merit ZT of the Pnma and R3m phases of GeS and GeSe. Our results suggest that n-type GeSe may be a good partner for p-type SnSe in a thermoelectric couple.
Extending rigid electron-deficient skeletons and appending electron-rich units to build high-efficiency red-emitting pyrene-derived TADF materials
Authors: Chang Xiang , Lu Kaiyu , Jiang Kai , Ma Bin , Huang Jingwei , Gan Xiangqin , Liu Yu , Yu Junting , Zhu Weiguo
Published: October 2023

In order to study the effect of substituted units at the K-region on emissive behavior of pyrene derivatives and obtain highly efficient red-emitting TADF materials, we designed and synthesized two pyrene-derived TADF materials.
Microrchidia 2/histone deacetylase 1 complex regulates E-cadherin gene expression and function
Authors: Thomas Liz , Chutani Namita , R Krishna , Nair Asha S. , Yellapu Nanda Kumar , Karyala Prashanthi , Pakala Suresh B.
Published: October 2023

Although Microrchidia 2 (MORC2) is widely overexpressed in human malignancies and linked to cancer cell proliferation, metabolism, and metastasis, the mechanism of action of MORC2 in cancer cell migration and invasion is yet undeciphered. Here, we identified for the first time that MORC2, a chromatin remodeler, regulates E-cadherin expression and, subsequently regulates breast cancer cell migration and invasion. We observed a negative correlation between the expression levels of MORC2 and E-cadherin in breast cancer. Furthermore, the overexpression of MORC2 resulted in decreased expression levels of E-cadherin. In addition, co-immunoprecipitation and chromatin immunoprecipitation assays revealed that MORC2 interacts with HDAC1 and gets recruited onto the E-cadherin promoter to inhibit its transcription, thereby suppress its expression. Consequently, knockdown of HDAC1 in MORC2-overexpressing cells led to reduced cancer cell migration and invasion. Interestingly, we noticed that MORC2-regulated glucose metabolism via c-Myc, and LDHA, also modulates the expression of E-cadherin. Collectively, these results demonstrate for the first time a mechanistic role for MORC2 as an upstream regulator of E-cadherin expression and its associated functions in breast cancer.
Assessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1
Authors: Donald Heather , Blane Ashleigh , Buthelezi Sindisiwe , Naicker Previn , Stoychev Stoyan , Majakwara Jacob , Fanucchi Sylvia
Published: October 2023

YY1 is a ubiquitously expressed, intrinsically disordered transcription factor involved in neural development. The oligomeric state of YY1 varies depending on the environment. These structural changes may alter its DNA binding ability and hence its transcriptional activity. Just as YY1’s oligomeric state can impact its role in transcription, so does its interaction with other proteins such as FOXP2. The aim of this work is to study the structure and dynamics of YY1 so as to determine the influence of oligomerisation and associations with FOXP2 on its DNA binding mechanism. The results confirm that YY1 is primarily a disordered protein, but it does consist of certain specific structured regions. We observed that YY1 quaternary structure is a heterogenous mixture of oligomers, the overall size of which is dependent on ionic strength. Both YY1 oligomerisation and its dynamic behaviour are further subject to changes upon DNA binding, whereby increases in DNA concentration result in a decrease in the size of YY1 oligomers. YY1 and the FOXP2 forkhead domain were found to interact with each other both in isolation and in the presence of YY1-specific DNA. The heterogeneous, dynamic multimerisation of YY1 identified in this work is, therefore likely to be important for its ability to make heterologous associations with other proteins such as FOXP2. The interactions that YY1 makes with itself, FOXP2 and DNA form part of an intricate mechanism of transcriptional regulation by YY1, which is vital for appropriate neural development.
Gastruloid optimization
Authors: Avni Lara , Farag Naama , Ghosh Binita , Nachman Iftach
Published: October 2023

The young field of gastruloids brings promise to modeling and understanding early embryonic development. However, being a complex model, gastruloids are prone to variability at different levels. In this perspective, we define the different levels of gastruloid variability, and parameters over which it can be measured. We discuss potential sources for variability, and then propose methods to better control and reduce it. We provide an example from definitive endoderm progression in gastruloids, where we harness gastruloid-to-gastruloid variation in early parameters to identify key driving factors for endoderm morphology. We then devise interventions that steer morphological outcome. A better control over the developmental progression of gastruloids will enhance their utility in both basic research and biomedical applications.
A Preliminary Investigation of Stakeholders' Perspectives on Cognitive Fatigue After Childhood Brain Injury
Authors: Riccardi Jessica Salley
Published: October 2023

Background:

Cognitive fatigue after childhood acquired brain injury (ABI) is known to negatively impact engagement in typical academic and social activities, yet limited evidence is available to inform speech-language pathologists' (SLPs') clinical practices. The purpose of this research study was to explore stakeholders' perspectives on cognitive fatigue for children with ABI to inform future directions for clinicians and researchers.

Method:

Twelve parents of children with traumatic brain injury and 35 SLPs participated in an online survey with 33 and 49 questions, respectively, including participant characteristics and perspectives on cognitive fatigue.

Results:

Parents reported being between “somewhat” and “highly aware” about cognitive fatigue, whereas SLPs reported being between “neither aware or not aware” and “somewhat aware.” Parents reported being between “somewhat comfortable” and “very comfortable,” whereas SLPs reported being between “neither comfortable or uncomfortable” and “somewhat comfortable” addressing cognitive fatigue in children with ABI. SLPs “somewhat” to “strongly” agreed that cognitive fatigue for children with ABI was within their scope of practice. Parents and SLPs reported accommodations and strategies useful to managing cognitive fatigue in children with brain injury, as well as factors that worsen and lessen cognitive fatigue.

Conclusions:

While additional foundational and translation research is needed, the perspectives of parents and SLPs begin to address a critical gap in SLPs' assessment and management of cognitive fatigue in children with ABI.

Supplemental Material:

https://doi.org/10.23641/asha.24216576
A polyphenol‐induced hydroxyapatite coating modulates corrosion resistance and biocompatibility of magnesium alloys
Authors: Chai Tao , Zhang Hao , Shen Xiaolong , Wang Haibo , Fan Xingping , Wang Binbin , He Dingying , Su Jia
Published: October 2023

In order to solve the problem of excessive degradation rate and insufficient biocompatibility of magnesium‐based bone implants, a polyphenol (EGCG) induced hydroxyapatite (HA) coating was prepared on the surface of AZ31 alloy. The physical and chemical properties and corrosion resistance of the coating were analysed in depth, and its biocompatibility was preliminarily explored in vitro. The results showed that the polyphenol (EGCG) conversion coating constructed on the AZ31 could successfully induce the formation of HA by complexing the phenolic hydroxyl group with calcium ions. The electrochemical and long‐term immersion experiments showed that the corrosion resistance of EGCG/HA composite coating was significantly improved. The self‐corrosion current density, hydrogen evolution and the increase of pH value of AZ31‐EGCG/HA were significantly lower than those of AZ31. On the basis of inhibiting the excessive corrosion of the substrate, the composite coating significantly improves the compatibility of pre‐osteoblasts, supports the adhesion and spreading and effectively reduces the haemolysis rate to less than 5%. The preparation method of the coating is simple, low cost and suitable for complex shape surfaces, which can significantly improve the corrosion resistance and biocompatibility of the AZ31 substrate. It is expected to provide a solution for the surface modification of magnesium‐based bone implants.
Distributed feedback optimisation based optimal power flow control in fully inverter based islanded AC microgrids
Authors: Cheng Y. , Liu Tao , Hill David John
Published: October 2023

A novel distributed feedback optimisation (FO) based control method is proposed to control grid‐forming inverters (GFMIs) in fully inverter‐based islanded AC microgrids (MGs). The proposed controller has two control layers. The upper layer uses FO to calculate the frequency and voltage setpoints of GFMIs, whereas the lower layer makes GFMIs track these setpoints. The proposed control method takes advantage of the flexibility of voltage control to regulate the system frequency, maintain both active power and reactive power sharing accuracies, keep bus voltage within allowable range and meanwhile preserves the optimality of the closed‐loop system in term of optimal power flow. The gradient descent method is used to solve the proposed FO problem based on the real‐time measurements in the MGs, which is implemented in a distributed way, and thus eliminates the need for a central controller. Case studies show the effectiveness of the proposed method.

The cover image is based on the Research Article Distributed feedback optimisation based optimal power flow control in fully inverter based islanded AC microgrids by Y. Cheng et al., https://doi.org/10.1049/stg2.12132.
Planetary companions orbiting the M dwarfs GJ 724 and GJ 3988
Authors: Gorrini P. , Kemmer J. , Dreizler S. , Burn R. , Hirano T. , Pozuelos F. J. , Kuzuhara M. , Caballero J. A. , Amado P. J. , Harakawa H. , Kudo T. , Quirrenbach A. , Reiners A. , Ribas I. , Béjar V. J. S. , Chaturvedi P. , Cifuentes C. , Galadí-Enríquez D. , Hatzes A. P. , Kaminski A. , Kotani T. , Kürster M. , Livingston J. H. , López González M. J. , Montes D. , Morales J. C. , Murgas F. , Omiya M. , Pallé E. , Rodríguez E. , Sato B. , Schweitzer A. , Shan Y. , Takarada T. , Tal-Or L. , Tamura M. , Vievard S. , Zapatero Osorio M. R. , Zechmeister M.
Published: October 2023

We report the discovery of two exoplanets around the M dwarfs GJ 724 and GJ 3988 using the radial velocity (RV) method. We obtained a total of 153 3.5 m Calar Alto/CARMENES spectra for both targets and measured their RVs and activity indicators. We also added archival ESO/HARPS data for GJ 724 and infrared RV measurements from Subaru/IRD for GJ 3988. We searched for periodic and stable signals to subsequently construct Keplerian models, considering different numbers of planets, and we selected the best models based on their Bayesian evidence. Gaussian process (GP) regression was included in some models to account for activity signals. For both systems, the best model corresponds to one single planet. The minimum masses are 10.75−0.87+0.96 and 3.69−0.41+0.42 Earth-masses for GJ 724 b and GJ 3988 b, respectively. Both planets have short periods (P < 10 d) and, therefore, they orbit their star closely (a < 0.05 au). GJ 724 b has an eccentric orbit (e = 0.577−0.052+0.055), whereas the orbit of GJ 3988 b is circular. The high eccentricity of GJ 724 b makes it the most eccentric single exoplanet (to this date) around an M dwarf. Thus, we suggest a further analysis to understand its configuration in the context of planetary formation and architecture. In contrast, GJ 3988 b is an example of a common type of planet around mid-M dwarfs.
Reconciling results of 2019 and 2020 stellar occultations on Pluto’s atmosphere
Authors: Yuan Ye , Li Fan , Fu Yanning , Chen Jian , Tan Wei , Zhang Shuai , Zhang Wei , Zhang Chen , Zhang Qiang , Ye Jiahui , Li Delai , Zhu Yijing , Fu Zhensen , Zhu Ansheng , Chen Yue , Xu Jun , Zhang Yang
Published: October 2023

A stellar occultation by Pluto on 5 September 2019 yielded positive detections at two separate stations. Using an approach consistent with comparable studies, we derived a surface pressure of 11.478 ± 0.55 µbar for Pluto’s atmosphere from the observations of this event. In addition, to avoid potential method inconsistencies when comparing with historical pressure measurements, we reanalyzed the data for the 15 August 2018 and 17 July 2019 events. All the new measurements provide a bridge between the two different perspectives on the pressure variation since 2015: a rapid pressure drop from previous studies of the 15 August 2018 and 17 July 2019 events and a plateau phase from that of the 6 June 2020 event. The pressure measurement from the 5 September 2019 event aligns with those from 2016, 2018, and 2020, supporting the latter perspective. While the measurements from the 4 June 2011 and 17 July 2019 events suggest probable V-shaped pressure variations that are unaccounted for by the volatile transport model (VTM), the VTM remains applicable on average. Furthermore, the validity of the V-shaped variations is debatable given the stellar faintness of the 4 June 2011 event and the grazing single-chord geometry of the 17 July 2019 event. To reveal and understand all of the significant pressure variations of Pluto’s atmosphere, it is essential to provide constraints on both the short-term and long-term evolution of the interacting atmosphere and surface by continuous pressure monitoring through occultation observations whenever possible, and to complement these with frequent spectroscopy and photometry of the surface.
Der Beitrag von Gesundheitskonferenzen und Gesundheitsregionen zu
regionaler Planung und Steuerung im Gesundheitswesen – ein
Überblick auf Ebene der Bundesländer
Authors: Geuter Gunnar , Beiwinkel Till , Oesterle Lea , Reyer Maren , Bödeker Malte , Haack Marius , Scriba Steffen , Preuss Maren
Published: October 2023

Die Weiterentwicklung ressort- und sektorenübergreifender Koordination
und Kooperation wird im deutschen Gesundheitswesen seit Langem gefordert.
Über den Öffentlichen Gesundheitsdienst sind in vielen
Bundesländern in den vergangenen Jahren Netzwerke zu
gesundheitsbezogenen Themen auf regionaler Ebene, sogenannte
Gesundheitskonferenzen oder Gesundheitsregionen, gebildet worden. Sie leisten
einen wichtigen Beitrag zu regionaler Planung und Steuerung in den
Handlungsfeldern Gesundheitsförderung und Prävention,
Gesundheitsversorgung sowie Pflege, indem sie Akteure auf kommunaler Ebene
vernetzen und gesundheitsbezogene Aktivitäten zu einem regionalen
Gesamtansatz weiterentwickeln. Die vorliegende narrative
Übersichtsarbeit wurde unter Mitwirkung von Expertinnen und Experten aus
mehreren Bundesländern erarbeitet und hat zum Ziel, eine
Übersicht über die Merkmale, Themenschwerpunkte und Ergebnisse
von Gesundheitskonferenzen und Gesundheitsregionen zu geben. Zudem werden
Unterschiede und Gemeinsamkeiten zwischen den Bundesländern sowie deren
landesseitige Flankierungs- und Unterstützungsmaßnahmen im
Rahmen von Förderprogrammen und gesetzlichen Grundlagen dargestellt. Es
zeigt sich, dass Gesundheitskonferenzen und Gesundheitsregionen in einer
Vielzahl der Landkreise und kreisfreien Städte bzw. auf Bezirksebene der
Stadtstaaten zu finden sind, oft bereits langjährig bestehen und auf
Basis bisheriger Evaluationen positive Wirkungen auf die regionale
Zusammenarbeit über die Ressort-, Sektoren- und Berufsgrenzen entfalten.
Sie bearbeiten ein breites Themenspektrum lokaler Bedarfe und Problemlagen mit
dem Ziel, Schnittstellen und Synergien zu nutzen sowie bestehende
Herausforderungen in der regionalen Versorgung und Vorsorge der
Bevölkerung zu begegnen. Neben dem Aufbau von Netzwerkstrukturen, der
Erhebung gesundheitlicher Bedarfe und der Entwicklung von Strategien entwickeln
sie vielfältige konkrete Kooperationsprojekte zur Verbesserung der
Gesundheit der Bevölkerung vor Ort. Abschließend wird die
Bedeutung einer gemeinwohlorientierten, kommunalen Planungs- und
Steuerungsfunktion des Öffentlichen Gesundheitsdienstes angesichts
zukünftiger Herausforderungen im Gesundheitswesen diskutiert und
Empfehlungen zu den Rahmenbedingungen beim Aufbau von Gesundheitskonferenzen und
Gesundheitsregionen sowie deren zukünftiger Weiterentwicklung
abgeleitet.
Pandemie-Management in Unterkünften für
Geflüchtete – Ergebnisse einer mixed methods-Studie
während der COVID-19-Pandemie.
Authors: Führer Amand , Pacolli-Tabaku Latife , Kompa Paula , Yılmaz-Aslan Yüce , Brzoska Patrick
Published: October 2023

Hintergrund Geflüchtete sind in Deutschland oft in
Sammelunterkünften untergebracht, in denen ihr Einfluss auf die
Alltagsgestaltung stark beschränkt ist. Während der
COVID-19-Pandemie standen die Sammelunterkünfte daher in der besonderen
Verantwortung, Maßnahmen zu ergreifen, um die Gesundheit der Bewohner zu
schützen. Im Rahmen einer mixed methods-Studie wurde untersucht, wie
diese Aufgabe bewältigt wurde und wie sich die Pandemie auf den Alltag
in Sammelunterkünften ausgewirkt hat, um daraus Empfehlungen für
die Praxis abzuleiten.

Methoden In einem ersten Schritt wurde die Literatur zum Umgang mit
Ausbrüchen infektiöser Erkrankungen in
Sammelunterkünften für Geflüchtete in einem Scoping
Review analysiert. Auf den Ergebnissen des Reviews aufbauend, wurde dann das
Pandemie-Management in einem Online-Survey und parallel dazu in Interviews mit
Experten und Bewohnern von Sammelunterkünften untersucht. In einem
dritten Schritt wurden die Ergebnisse der vorangehenden Schritte zusammengefasst
und mit einem Experten-Panel diskutiert. In zwei Diskussionsrunden im Abstand
von zwei Monaten wurden mit dem Experten-Panel Empfehlungen für die
Praxis entwickelt.

Ergebnisse Die in der Untersuchung erfassten Sammelunterkünfte
waren unzureichend auf die Pandemie vorbereitet und haben oft erst im Verlauf
der Pandemie Krisenpläne entwickelt. Häufig sahen die
Krisenpläne die Etablierung von Krisenstäben vor, in denen die
Interessen und Perspektiven der Bewohner der Einrichtungen jedoch in der Regel
nicht vertreten waren. Dies hat in der Folge zu Problemen geführt:
Pandemiemaßnahmen wurden häufig nicht rechtzeitig oder nicht
ausreichend verständlich kommuniziert; durch Maßnahmen
entstehende Versorgungslücken wurden nicht erkannt und nicht adressiert;
und mit der Pandemie und Quarantänemaßnahmen einhergehende
psychosoziale Belastungen wurden nicht ausreichend abgefedert.

Schlussfolgerung

• Sammelunterkünfte für Geflüchtete
sollten unabhängig von der Pandemie Mechanismen etablieren, um die
Interessen und Perspektiven der Bewohner strukturiert in Entscheidungsprozesse
zu integrieren. • Je nach Art der Sammelunterkunft sollte dies durch
Einbindung von Bewohnern in Entscheidungsgremien oder eine andere geeignete
Interessenvertretung verwirklicht werden. • Während der Pandemie
eingeführte Maßnahmen, die sich negativ auf die psychosoziale
Situation der Bewohner auswirken können, sollten beendet werden, sobald
ihre seuchenhygienische Rechtfertigung nicht mehr gegeben ist.
Vitamin C und seine Bedeutung für die Hautgesundheit
Authors: Rühtz Aline-Maria , Vollbracht Claudia
Published: October 2023

Die Haut ist unser Gewebesystem, das den Abschluss gegenüber der Außenwelt und gleichzeitig die Verbindung mit ihr bildet. Dieser faszinierende Spagat kann nur aufrechterhalten werden, wenn sehr viele Prozesse in unserem Körper Hand in Hand arbeiten. Oxidativer Stress wird als Ursache für Hautalterung und viele Hauterkrankungen verantwortlich gemacht. Vitamin C ist eines der wichtigsten physiologischen Antioxidantien und damit ein bedeutender Immunmodulator, der die Infektabwehr unterstützen und gleichzeitig überschießende Entzündungen eindämmen kann. Zudem ist der essenzielle Mikronährstoff enzymatischer Kofaktor vieler hautrelevanter Stoffwechselprozesse. Diese Eigenschaften verleihen ihm eine große Bedeutung bei der Behandlung von Hauterkrankungen und Wundheilungsstörungen (z. B. nach ästhetischen Verfahren).