bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case Report on Non Ischemic Dilated Cardiomyopathy
Authors: Devakar L , Kashyap Ritik , Saha Kumar Akash , Kumar Amit
Published: December 2023

Non-Ischemic Dilated Cardiomyopathy is a condition in which the dilation of left ventricle occurs. Due to this condition motor movement of the ventricles (contraction) of heart decreases which results in less efflux of oxygenated blood from the heart to the body. The clinical manifestations include chest pain, SOB, progressive dry cough, fatigue and restlessness. This is a case of 18yr male patient diagnosed as NIDCM with the above symptoms. His clinical findings (ECG, 2D ECHO) were abnormal and for the proper management of this case drugs like anti-hypertensive, inotropes, diuretics and anti-allergic were prescribed along with some non-pharmacological treatment.
A Study on the Assessment of Mental Cognitive Functions among the COPD Patients of Various Severity Stages
Authors: Kranthi Priya P , Ray Pravin Kumar , Singh Nisha , Beulah S , Manju V , Dash Somnath
Published: December 2023

Aim: The main aim of the study is to assess the mental cognitive functions among COPD patients of different severity stages. Materials and methods: This was a cross sectional study conducted for a period of 6 months in outpatient department of respiratory medicine. A total of 100 patients of both gender and of all age groups, who were diagnosed with COPD were included in the study. Results: Majority of the patients were observed with severe COPD (48%) followed by very severe COPD (26%). Majority of the patients were with moderate cognitive impairment (42%) followed by mild cognitive impairment (32%). Majority of the patients were observed to be with grade II (53%) followed by grade-I (23%). Most of the patients with very severe COPD were observed with moderate cognitive impairment (46.2%) followed by severe cognitive impairment (42.3%). Conclusion: In this study, majority of the patients with COPD were in the age group 45-54 years and most of the patients were observed with severe COPD. Majority of the patients were with moderate cognitive impairment and most of the patients were observed to be with grade II severity. Clinical pharmacists should take the responsibility in creating awareness regarding the cognitive functions among the COPD patients which may impact treatment strategies.
A Review on Lipospheres
Authors: Ramakrishna Gummadi , Kakarparthy Ravishankar
Published: December 2023

Lipospheres are made up of lipid based water dispersible solid micro particles ranging from the size between 0.01 to 100 micro meters in diameter. Lipospheres are mainly composed of triglycerides, waxes or fatty acids. It is developed for parenteral and topical drug delivery of bioactive compounds. In lipospheres, a solid hydrophobic fat core stabilized by monolayer of phospholipid molecules instilled in their surface which is a potential entrance enhancer. Lecithin has tendency for epidermal tissue and shows skin hydration. Lipospheres are favourable method for the development of cosmetic preparations. The small size of the lipid particles absorbed through stratum corneum by penetration mechanism. Lipid entrapment plays a major role in the formulation of lipospheres. Among all the methods, melt dispersion technique having highest entrapment efficiency than solvent evaporation method.
Pharmacological and Non-pharmacological Management of Bipolar Disorder with Comorbid Huntington's Disease: A Case Report
Authors: Sarella Prakash Nathaniel Kumar , Dadishetti Janki Pavanilakshmi , Asogwa Patrick Oliver , Kakarparthy Ravishankar
Published: December 2023

Bipolar disorder and Huntington's disease are chronic, debilitating conditions that may present during early to middle adulthood. While reports exist on managing each condition separately, data on their comorbidity is limited. We describe a case of successfully treating a patient with comorbid bipolar disorder and Huntington's disease. A 36-year-old male presented with mania, psychosis and involuntary movements. He was diagnosed with bipolar disorder type I and Huntington's disease based on the clinical features and family history. He was treated with quetiapine, valproate, lorazepam, lithium, ECT and TMS. Investigations including blood tests, CT scan and psychiatric assessment were performed. The patient's symptoms showed some improvement with treatment. However, optimization of pharmacotherapy and use of ECT/TMS as maintenance therapy were recommended to achieve better control of bipolar symptoms. Involuntary movements and gait disturbance were attributed to Huntington's disease. This case highlights the diagnostic and management challenges in comorbid bipolar disorder and Huntington's disease. Despite pharmacological and non-pharmacological treatments, coordinated multidisciplinary care should be provided. Insights from this case report may help to optimize the management in similar patients.
Data Analytics and Artificial Intelligence
Authors: Kosuru Slesha Kumar , Tadi Suvarna , G Jyothi , K Sravani , D Gowthami , K Sai Siva Saran
Published: December 2023

In the realm of modern industry and technology, the amalgamation of data analytics and artificial intelligence (AI) has emerged as a formidable force, propelling significant transformations across various sectors. This partnership between data analytics and AI is not merely reshaping conventional practices but also uncovering valuable insights that were previously hidden from view. The collaboration between these two disciplines is exemplified by data analytics, which involves the systematic examination of extensive datasets to extract meaningful insights through data refinement and interpretation. Dedicated professionals are actively engaged in the pursuit of cutting-edge analytical techniques that empower precise, efficient and sustainable pharmaceutical analysis. They are committed to harnessing the power of data analytics and artificial intelligence to elevate the speed and accuracy of data interpretation, making the drug development process more efficient and reliable. Adaptation to an evolving regulatory landscape is another crucial aspect of the analysts' roles. They diligently work to meet ever-changing standards and ensure that analytical methods are not just innovative but compliant with the necessary regulatory guidelines. A spirit of collaboration and data sharing permeates the community. In this world of pharmaceutical analysis, the dedicated analysts are not just observers of the future. They are the architects of progress and innovation, shaping a future characterized by ground breaking discoveries and enhanced pharmaceutical solutions.
Synergistic Nootropic Activity of Ethanolic Leaf Extracts of Ziziphus Jujuba and Tinospora Cordifolia against Stress Induced Rats
Authors: Kakaraparthy Ravishankar , K Gnaneswari , Cherakani Veeradurgalakshmi
Published: December 2023

Aim: The present investigation deals with the preliminary phytochemical analysis, synergistic nootropic activity of ethanolic leaf extracts of Ziziphus jujuba and Tinospora cordifolia against stress induced rats.

Methods: Nootropic activity was observed in Albino Wistar rats of either sex using behavior paradigms such as elevated plus maze, staircase and morris water maze.

Results: In elevated plus maze and morris water maze, the rats were treated with extracts at doses (100 and 200 mg/kg-po) for 9 days and were observed on 9th day of treatment. Piracetam (100 mg/kg) was used as standard drug for comparison. In the elevated plus maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the transfer latency when compared to 100 mg/kg. In the staircase, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the number of climbings and the number of rearings when compared to 100 mg/kg. In the morris water maze, the combination of leaf extracts of Ziziphus jujuba and Tinospora cordifolia at 200mg/kg significantly decreased the escape latency when compared to 100 mg/kg and control.

Conclusion: The combination of these two medicinal plants Ziziphus jujuba and Tinospora cordifolia possessed significant synergistic nootropic activity and further research attempts can be made so as to isolate the novel moiety molecules which can be elucidated and can be evaluated for their therapeutic potential.
Evaluation of Antibacterial and Wound Healing Activities of Ethanolic Extract of Linum Usitatissimum (Flax Seed) on Rabbits
Authors: Kakaraparthy Ravishankar , K Sruthi , Banerjee Monika
Published: December 2023

Aim: Linum usitatissimum was evaluated for its antibacterial and wound-healing capacity.

Methods: This method involved the collection and authentication of the plant, preparation of herbal extract, phytochemical analysis for the prepared extract, development of an herbal formulation for the prepared extract, evaluation of the antibacterial activity of Linum usitatissimum seed extract and the evaluation of the wound healing activity by Excision wound model. The antibiotic activity was studied by cup plate method using a nutrient agar medium. The zone of inhibition was then determined after culturing and incubation.

Results: The results of the extract of Linum usitatissimum show antibacterial activity as demonstrated by zone of inhibition when cultured with selected bacterial species (both gram positive and gram negative). Different concentrations of (200 ?g /ml) and (400?g/ml) were used. The extract showed an improved wound healing capacity from the third application as demonstrated by the increase in the percentage of healing (9.55 ± 0.04%) with a significant increase on the sixth day (23 ± 0.4%). Betadine was used as a standard medicament for wound healing.

Conclusion: The present research study demonstrated that the medicinal plant Linum usitatissimum seed extract possesses significant antibacterial and wound-healing properties. Based on the observation and the significant results obtained, the researchers can draw that the ethanolic seed extract of Linum usitatissimum produced antibacterial and wound healing activities and the results were authenticated by comparing with reference drugs. Further scientific studies can be taken up and detailed study on the preliminary phytochemical constituent present which may be responsible for these biological activities. At this junction of time, this research study provides justification and scientific evidence for further pharmacological activities that are evaluated in our laboratory.
Concurrent Diagnosis of Renal Calculi, Uterine Fibroids and Ovarian Cysts: A Complex Case Study
Authors: Sri Lakshmi Sanipini , Sarella Prakash Nathaniel Kumar , Adarsh Kelangi , Lakshmi Padmini Peddinti , Vijayraj Kumar Molleti
Published: December 2023

This case report presents a complex clinical scenario in a 41-year-old female patient, highlighting the concurrent diagnosis of renal calculi, uterine fibroids, and ovarian cysts. The patient's medical history reveals a prior diagnosis of renal calculi six months ago, characterized by flank pain and urinary symptoms. More recently, the patient sought medical attention due to abnormal bleeding and discomfort, leading to the discovery of a bulky uterus with fibroids and a left ovarian cyst categorized as O-RADS 2 (benign). Notably, the patient was undergoing hormone replacement therapy for perimenopausal symptoms. While these conditions typically have distinct etiologies and anatomical locations, their simultaneous presence prompts consideration of potential systemic factors or shared risk factors contributing to this multifaceted clinical presentation. The case underscores the importance of comprehensive evaluation and individualized management strategies in patients with multiple concurrent diagnoses, emphasizing the need for multidisciplinary collaboration between urologists and gynecologists to optimize patient care and outcomes. Further investigation may be warranted to explore any potential connections or underlying factors linking these diverse medical conditions.
A Review on Analytical Challenges in Complex Formulations
Authors: Kosuru Slesha Kumar , V Srinivasa Rao , Tadi Suvarna , Ch Jhansi , G Santhosh Kumar
Published: December 2023

In the realm of pharmaceutical development and manufacturing, the intricate world of complex drug formulations has garnered significant attention. These multifaceted formulations, often comprising a blend of active pharmaceutical ingredients (APIs) and excipients, present a myriad of analytical challenges. To address these complexities and ensure the safety, efficacy and quality of pharmaceutical products, the industry relies on a combination of advanced analytical techniques, comprehensive knowledge and unwavering commitment to regulatory standards. In the pursuit of solutions to these analytical challenges, the industry is also exploring emerging technologies, including microfluidic devices and mass spectrometry imaging. These innovative tools offer the potential for more detailed and precise analysis of complex formulations. The analytical challenges associated with complex drug formulations demand a multidisciplinary approach, combining traditional and advanced techniques to address the unique characteristics and requirements of each product. Overcoming these challenges is crucial, as it ensures the safety, efficacy and quality of pharmaceutical products, particularly in an industry driven by innovation and the quest to provide cutting-edge therapeutic solutions.
PENTINGNYA MANAJEMEN KEWIRAUSAHAAN BAGI MASYARAKAT PEDESAAN DESA GAMLAMO KECAMATAN MOROTAI TIMUR KABUPATEN PULAU MOROTAI
Authors: Sabuhari Rahmat , Abdul Haji Sulfi , Man Soleman Marwan , Wajir Jabid Abdullah
Published: December 2023

Pemerintah Desa diharapkan mampu berdikari dan menghadapi tantangan dengan mengidentifikasi berbagai potensi usaha yang dapat meningkatkan pendapatan masyarakat desa. Lebih jauh ke depan di era globalisasi masyarakat di Kabupaten Pulau Morotai mampu berwirausaha dan menjadi salah satu pilot proyek yang dapat dijadikan peluang untuk meningkatkan kesejahteraan masyarakat melalui berwirausaha di desa. Sosialisasi tentang Pentingnya Manajemen Kewirausahaan Bagi Masyarakat Pedesaan Desa Gamlamo Kecamatan Morotai Timur Kabupaten Pulau Morotai ini adalah untuk meningkatkan pengetahuan dan pemahaman mengenai kewirausahaan sekaligus guna meningkatkan taraf hidup dan menambah pendapatan masyarakat. Pelaksanaan kegiatan pelatihan dilaksanakan pada bulan Mei dan Oktober 2023 di aula Kantor Desa Gamlamo.
Jumlah peserta sebanyak 20 orang Aparatur Desa dan masyarakat yang telah menjalankan usaha di desa dengan berbagai latar belakang pendidikan dan keluarga yang berbeda, serta tingkat sosial dan ekonomi yang beragam. Metode yang digunakan: metode ceramah, tanya jawab, dan diskusi. Pelatihan ini berisi materi tentang dasar-dasar kewirausahaan dan kemampuan mengidentifikasi potensi usaha masyarakat pedesaan sehingga diharapkan memberikan pengetahuan yang lebih luas yang langsung diterapkan dalam kehidupan sehari-hari dan dapat mengubah pola pikir tradisional kearah model usaha yang lebih maju dalam berwirausaha.
Harapan ke depan tentunya diperlukan tindak lanjut oleh Pemerintah Kecamatan Morotai Timur dan semua pihak yang terkait. Dan perlu dilakukan kerjasama yang lebih erat dan terencana antara Perguruan Tinggi dengan Pemerintah Daerah untuk menggali potensi-potensi yang ada di wilayah pedesaan lainnya.
Peningkatan Keterampilan Berbicara Melalui Penerapan Model PBL, Non-Directive, dan NHT
Authors: Sandi Riswana , Anwar Khairil
Published: December 2023

Rendahnya aktivitas dan keterampilan berbicara peserta didik berdampak pada hasil belajar muatan Bahasa Indonesia materi Teks Non-Fiksi pada Kelas IV SD Muhammadiyah 5 Banjarmasin. Permasalahan yang muncul di dalam kelas disebabkan karena pembelajaran bersifat satu arah dan kurang bermakna bagi peserta didik. Penelitian ini menggunakan jenis penelitian tindakan kelas (PTK) dengan tujuan memperbaiki proses belajar mengajar. Salah satu upaya yang dilakukan adalah dengan menerapkan model pembelajaran Problem Based Learning, Non-Directive dan Number Head Together. Terjadi peningkatan di setiap pertemuan, diantaranya aktivitas guru telah terlaksana dengan sangat baik, aktivitas peserta didik berada pada kriteria sangat aktif, yang telah melampaui indikator keberhasilan yakni sebesar 93%. Kemudian hasil belajar peserta didik berada pada kriteria kualifikasi tuntas pada ranah afektif, kognitif dan psikomotorik yang telah melampaui indikator keberhasilan yakni masing-masing 87%, 93%, 87%. Dapat disimpulkan bahwa model PBL, Non-Directive dan NHT dapat meningkatkan aktivitas guru, aktivitas peserta didik dan hasil belajar peserta didik pada keterampilan berbicara dalam pembelajaran Bahasa Indonesia materi Teks Non-Fiksi Kelas IV SD Muhammadiyah 5 Banjarmasin.
California verbal learning test trial among the polish homeless
Authors: Romaszko-Wojtowicz Anna , Borkowska Alina , Opalach Cezary , Romaszko Małgorzata , Łowczak Anna , Buciński Adam
Published: December 2023

Introduction

Reports on the low intellectual level of the homeless are quite numerous and independent of the geographical location of the study.

Aim

The aim is to assess cognitive functions among the homeless as measured by the California verbal learning test (CVLT).

Material and methods

In our study we included 102 homeless people to assess the functioning of verbal memory using the CVLT. The absolute value of the sum of the results in tasks 1–5 amounted only to 36.21 (SD 10.63). Almost 42% of the subjects obtained a sten score of 1 or 2 for this task.

Results and discussion

In all tested CVLT parameters the homeless people, who were the respondents of the present study, obtained results that were significantly below standards (low or very low).

Conclusions

These results indicate the presence of large numbers of people with severe verbal memory disorders among the homeless.
Awareness of women about cervical cancer prevention
Authors: Tałaj Anna Ewa , Cichostępska Danuta
Published: December 2023

Wprowadzenie

Pomimo tego, że na przestrzeni lat odnotowuje się postęp w dziedzinie profilaktyki nowotworów szyjki macicy, wciąż stawiane są liczne diagnozy tej choroby zarówno w Polsce, jak i na całym świecie.

Cel

Celem pracy jest sprawdzenie poziomu wiedzy kobiet zamieszkałych na terenie miasta Elbląg i pobliskich miejscowości na temat profilaktyki raka szyjki macicy (RSM).

Materiał i metody

W pracy wykorzystano metodę sondażu diagnostycznego, technikę ankiety oraz narzędzie badawcze, jakim jest kwestionariusz ankiety. Badania odbyły się w okresie od stycznia do marca 2022 roku, a poprzedzone zostały badaniem pilotażowym przeprowadzonym pod koniec grudnia 2021 roku. W badaniu uczestniczyły kobiety z miasta Elbląg i pobliskich miejscowości.

Wyniki i ich omówienie

Wynik badań potwierdza, że świadomość kobiet na temat profilaktyki raka szyjki macicy nie jest dostatecznie wysoka. Jedną z istotnych przyczyn tego stanu rzeczy jest zbyt małe rozpowszechnianie w społeczeństwie wiedzy i świadomości o RSM oraz o konieczności regularnego uczęszczania do ginekologa i wykonywania badania cytologicznego.

Wnioski

1. Zbyt niski poziom edukacji zdrowotnej z zakresu prozdrowotności oraz seksuologii jest przyczyną niedostatecznej wiedzy kobiet o RSM.
2. Lekarze, pielęgniarki i położne to najważniejsi promotorzy wiedzy na temat RSM.
3. Wciąż niedostateczny poziom wiedzy oraz świadomości kobiet z dziedziny profilaktyki RSM skutkuje nadal utrzymującym się na wysokim poziomie problemie rozpoznawania tych chorób wśród kobiet zarówno w Polsce, jak i na całym świecie.
4. Polska zalicza się do jednego z krajów unijnych, w którym najczęściej diagnozuje się nowe przypadki RSM.
Analysis of medical records from 2018–2020 of the Neonatology Department of the Provincial Hospital in Elbląg in terms of the occurrence of congenital malformations
Authors: Pietruszka Anna , Tałaj Anna Ewa
Published: December 2023

Wprowadzenie

Wrodzone wady rozwojowe definiowane są jako anatomiczne i funkcjonalne nieprawidłowości w obrębie tkanek i narządów. Są jedną z najczęstszych przyczyn zgonów i najczęściej powiązane są z niepełnosprawnością fizyczną i intelektualną.

Cel

Celem pracy jest określenie rodzaju wad wrodzonych zdiagnozowanych u noworodków urodzonych w Oddziale Neonatologicznym Wojewódzkiego Szpitala Zespolonego w Elblągu latach 2018–2020.

Materiał i metody

Materiał badań stanowiła dokumentacja medyczna noworodków urodzonych w latach 2018–2020 r. w Oddziale Neonatologicznym Wojewódzkiego Szpitala Zespolonego w Elblągu.

Wyniki i ich omówienie

Z analizy materiału badawczego wynika, że w roku 2018 zostało zdiagnozowanych najwięcej dzieci z wrodzonymi wadami rozwojowym (58,6%), większość wrodzonych wad rozwojowych wystąpiła u chłopców (55,7%). Największa wykrywalność była w ciąży pierwszej (35,7%) oraz wśród pierworódek (40%). Badane noworodki urodzone między 38. a 40. tygodniem ciąży miały zdiagnozowaną wrodzoną wadę rozwojową, a masa ciała dzieci z wadami była powyżej 1500 g (95,7%). Ciąże bliźniacze stanowiły 8,6% badanych noworodków, z czego 66,7% badanych bliźniąt pierwszych miało wrodzoną wadę rozwojową, a drugie z bliźniąt stanowiły 33,3%. W grupie badanych noworodków nie było zapłodnień metodą in vitro, a zgony badanych dzieci z wrodzoną wadą rozwojową stawiły 4,3% dzieci. Ze wszystkich diagnozowanych wrodzonych wad w układach najwięcej wad wystąpiło w układzie krążenia (19 wad).

Wnioski

1. Wrodzona wada rozwojowa serca w postaci ubytku przegrody międzykomorowej była najczęstszą wadą wśród badanych noworodków.
2. Żadna ze zmiennych niezależnych nie miała wpływu na wystąpienie wrodzonej wady serca u badanych noworodków.
3. W układzie krążenia u badanych noworodków zostało zdiagnozowanych najwięcej wrodzonych wad rozwojowych.
4. Ze zmiennych niezależnych tylko tydzień ciąży miał wpływ na wystąpienie wrodzonej wady rozwojowej w układzie krążenia u badanych noworodków.
Mean Electric Field of Dielectric Nanoparticle
Authors: Chkhartishvili Levan , Dekanosidze Shorena , Esiava Ramaz
Published: December 2023

The nanoscale effect of the formation of an electric field near the surface of a dielectric nanoparticle is discussed within the framework of the proposed model based on the reconstruction of the crystal surface, including the splitting of the surface atomic layer into two parallel sublayers consisting of atoms with only positive or only negative effective static electric charges, respectively. The mean electric field potential and strength are obtained depending on the distance from the surface and the numerical values of their parameters for hexagonal boron nitride are estimated.
Unveiling Advanced Computational Applications in Quantum Computing: A Comprehensive Review
Authors: Markna J H , Palatia T P , Gohel Smeetraj , Kataria Bharat
Published: December 2023

The field of advanced computing applications could experience a significant impact from quantum computing, which is a rapidly developing field with the potential to revolutionize numerous areas of science and technology. In this review, we explore into the various ways in which complex computational problems could be tackled by utilizing quantum computers, including machine learning, optimization, and simulation. One potential application of quantum computers is in machine learning, where they could be used to improve the accuracy and efficiency of algorithms. Complex optimization problems, such as those encountered in logistics and finance, can be addressed using quantum computers as well. Furthermore, the utilization of quantum computers could enable the simulation of intricate systems, such as molecules and materials, leading to significant applications in fields like Physics and Material Technology. Although quantum computers are currently in the early stages of development, they possess the potential to propel numerous areas of science and technology forward in a significant manner. Further research and development are needed to fully realize the potential of quantum computing in the field of advanced computing applications.
Metallic Nanoparticles Applications in Medicine
Authors: Anusha Rani Yavvari , Devamma M. Nagalakshmi
Published: December 2023

Metallic nanoparticles (MNPs) are revolutionizing the field of medicine with their unique properties and diverse applications. From targeted drug delivery and photothermal therapy to bioimaging and biosensing, MNPs hold immense potential to improve diagnosis, treatment, and disease monitoring. This review explores the current state of MNP research in medicine, highlighting their diverse applications, advantages, and challenges.
ENDOTHELIN-1 ROLE IN HUMAN EYE: A SYSTEMATIC REVIEW
Authors: Valerie Gunawan Alyssa Claudia , Caesari Putri Aquirina , Zerlinda Purnadi Natania , Atin Fulgensius
Published: December 2023

Background: Endothelin-1 (ET-1) is a potent vasoactive factor implicated in development of diabetic retinopathy, which is commonly associated with retinal edema and hyperglycemia. Although the vasomotor activity of venules contributes to the regulation of tissue fluid homeostasis, responses of human retinal venules to ET-1 under euglycemia and hyperglycemia remain unknown and the ET-1 receptor subtype corresponding to vasomotor function has not been determined.
The aim: This study aims to show endothelin-1 role in human eye.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database the results of our search brought up 44 articles, whereas the results of our search on SagePub brought up 95 articles. The results of the search conducted for the last year of 2013 yielded a total 15 articles for PubMed and 42 articles for SagePub. The result from title screening, a total 4 articles for PubMed and 12 articles for SagePub. In the end, we compiled a total of 8 papers. We included five research that met the criteria.
Conclusion: ET-1 (vasoconstrictor, mitogenic, pro-oxidative, and proinflammatory) is one of the most potent vasoconstrictors in the body and its action has a dual effect: on the one hand, it acts on receptors of ECs and pericytes; on the other hand, it has a mitogenic effect on VSMCs.
SURGICAL MANAGEMENT VERSUS NON-SURGICAL MANAGEMENT OF RIB FRACTURES IN CHEST TRAUMA: A SYSTEMATIC REVIEW
Authors: Atin Fulgensius , Soritua Silalahi Herbert , Prasetyanto R. Dhany , Jimmy Desanto Fridolino , Chindy Sulisty Heriberty
Published: December 2023

Background: Roughly ten percent of patients who visit trauma centers are estimated to have broken ribs. From a single, isolated fracture to a flail chest, rib fractures can occur in a variety of severity. Rib fractures substantially influence the rates of morbidity and mortality. There is still debate on how to treat chest injuries. Practical use varies greatly; one such example is the uneven application of surgical stabilization.
The aim: This study aims to assess the differences between surgical management and non-surgical management of rib fractures in chest trauma.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of the requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and ScienceDirect, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Results: In the PubMed database, the results of our search brought up 44 articles, whereas the results of our search on ScienceDirect brought up 303 articles. The results of the search conducted by title screening yielded a total 18 articles for PubMed and 13 articles for ScienceDirect. We compiled a total of 17 papers, 12 of which came from PubMed and 5 of which came from ScienceDirect. We excluded 1 review article, 1 duplicate article, 1 non-full text article, 2 protocol study, 2 articles having ineligible subjects, and 3 articles having insufficient outcomes data. In the end, we included seven research that met the criteria.
Conclusion: The outcomes of surgical and non-surgical methods for the management of rib fractures are comparable in terms of complications, length of hospital stay, and mortality.
DIFFERENTIAL ASSOCIATIONS OF MYOPIA WITH MAJOR AGE-RELATED EYE DISEASES : A SYSTEMATIC REVIEW
Authors: Valerie Gunawan Alyssa Claudia , Caesari Putri Aquirina , Atin Fulgensius
Published: December 2023

Background: Myopia or nearsightedness is a refractive error caused by excessive axial elongation.
Methods: By comparing itself to the standards set by the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020, this study was able to show that it met all of cthe requirements. So, the experts were able to make sure that the study was as up-to-date as it was possible to be. For this search approach, publications that came out between 2013 and 2023 were taken into account. Several different online reference sources, like Pubmed and SagePub, were used to do this. It was decided not to take into account review pieces, works that had already been published, or works that were only half done.
Result: In the PubMed database, the results of our search brought up 63 articles, whereas the results of our search on SagePub brought up 21 articles. The results of the search conducted for the last year of 2013 yielded a total 44 articles for PubMed and 8 articles for SagePub. In the end, we compiled a total of  4 papers, 3 of which came from PubMed and 1 of which came from SagePub. We included five research that met the criteria.
Conclusion: In summary, myopic eyes are less likely to have AMD and DR but more likely to have nuclear cataract, PSC, and POAG. The associations of myopia with AMD, DR, and POAG are mostly explained by longer AL. However, the association between myopia and nuclear cataract is explained by lens refraction rather than AL.
Effects of a Home-Based Exercise Programme on Shoulder Pain and Functional Status in Garment Workers
Authors: Siddiqui Hina Al Fatimah , Asif Muhammad , Raza Arooj , Sheikh Sana Iqbal , Siddiqui Muhammad Atif , Ahmed Noman
Published: December 2023

Background: Work-related musculoskeletal disorders, particularly shoulder pain, are a prevalent concern among garment workers, who often engage in repetitive and manual tasks. Previous research has indicated a high incidence of shoulder pain in this population, with a need for effective interventions to mitigate these issues.
Objective: The objective of this study was to evaluate the efficacy of a home-based exercise program in reducing shoulder pain and improving functional status among garment workers.
Methods: This experimental study involved 60 male and female tailors with work-related shoulder pain, randomly divided into an intervention and a control group (30 participants each). Participants were selected based on specific criteria, including experiencing pain in the glenohumeral joint area and showing at least two positive signs of shoulder impingement. Exclusion criteria included a history of rotator cuff surgery, shoulder dislocation, or pain only in the neck or shoulder blade. The intervention group underwent a four-week home-based exercise program, including stretching and strengthening exercises targeting the pectoralis minor muscle, upper trapezius, serratus anterior, and external shoulder rotation. The Shoulder Rating Questionnaire (SRQ) was used for pre- and post-intervention assessments.
Results: Post-intervention, the intervention group showed a significant increase in the SRQ score from 62.6 (±1.99) to 77.0 (±2.54) (p = 0.016), a reduction in work-related pain from 4.9 (±0.51) to 2.4 (±0.31) (p = 0.041), and a decrease in work-related disability from 4.3 (±0.40) to 2.6 (±0.46) (p = 0.032). The satisfaction score also significantly improved from 4.1 (±0.43) to 6.5 (±0.22) (p = 0.003). In contrast, the control group did not exhibit any significant changes in these measures.
Conclusion: The study demonstrates that a structured home-based exercise program can significantly reduce shoulder pain and improve functional status among garment workers. This suggests the potential for such interventions to be integrated into occupational health strategies, particularly in sectors prone to work-related musculoskeletal disorders.
Impact of Prophylactic Antibiotics in Ischemic Stroke Patients on Reduction of Hospital Stay.
Authors: Mehroon Razzaq Muhammad , Khan Wahaj Ul Hassan , Hussain Maryam , Hayat Qaiser , Waqar Hafsa , Wazir Saliha
Published: December 2023

Background: Ischemic stroke is a leading cause of morbidity and mortality, with post-stroke infections significantly impacting patient outcomes. The use of prophylactic antibiotics to prevent these infections and reduce hospital stay durations has been a subject of debate in the medical community.
Objective: This study aims to evaluate the impact of prophylactic antibiotic administration on the length of hospital stays in ischemic stroke patients.
Methods: Conducted at the Combined Military Hospital, Peshawar, this randomized control trial involved 115 patients, divided into two groups. Group 1 (55 patients) received prophylactic ceftriaxone, while Group 2 (60 patients) did not receive antibiotics. Inclusion criteria were a Glasgow Coma Scale (GCS) score 13 and above, with no pre-existing conditions necessitating antibiotics or complications from the stroke. The primary outcome was the duration of hospital stay.
Results: Group 1 had an average hospital stay of 6.65 days (SD: 2.06 days), while Group 2 had an average of 6.81 days (SD: 1.98 days). The P value of 0.677 indicated no statistically significant difference in hospital stay durations between the groups. Both groups had similar age and GCS score distributions.
Conclusion: The administration of prophylactic antibiotics to ischemic stroke patients did not significantly reduce hospital stay durations. Given the risks associated with antibiotic resistance and side effects, a patient-specific approach to prophylactic antibiotic use is recommended. Future research should focus on identifying specific patient subgroups that may benefit from prophylactic antibiotics and optimal timing for their administration.
Assessment of Al3+ Ion Selectivity Coefficient (Kij) in Polyurethane Membranes Derived from Castor Oil (Ricinus communis. L) via Separated Solution Method
Authors: Jannah Firaihanil , Idroes Rinaldi , Nazaruddin Nazaruddin , Idris Nasrullah , Safitri Eka , Md Sani Nor Diyana
Published: December 2023

The influence of foreign ions on the response of Al3+ ISE-based polyurethane membranes from castor oil has been determined using SSM. The results showed that the presence of the foreign ions tested did not affect the sensitivity and response of Al3+ ISE. The influence of foreign ions Na+, K+, Li+, Pb2+, Ca2+, Co2+, Cu2+, Ni2+, Cr3+, and Fe3+ on the selectivity of ion-selective electrodes (Al3+ ISE) in the concentration range 1x10-9 – 1x10-4 M has been performed using separate methods. The results show that the presence of foreign ions does not affect the performance of Al3+ ISE with a Kij value < 1. The selectivity sequence of foreign ions is Fe3+ > Cr3+ > Pb2+ > Cu2+ > Ni2+ > Co2+ > Ca2+ > Li+ > Na+ > K+ respectively.
Kütahyalı Ressam Ahmet Yakupoğlu’nun Minyatürlerinde Tasavvuf Manzumeleri
Authors: GÜLER Kadir
Published: December 2023

Ahmet Yakupoğlu, yaşadığımız asrın çok yönlü sanatkârlarındandır. Kütahya’nın üç Ahmet Abisinden biri olan Yakupoğlu, Germiyanlı olan atalarının sanat ve kültürle yoğurduğu Kütahya’da yetişen samimi bir dergâh sanatkârıdır. Hocalarının el verdiği her sanat dalıyla ilgilenmiş ve o sanat dalının rahlesinde kendini çok iyi yetiştirmiştir. İyi bir eğitim almasına rağmen bunu öne çıkarmamış bir gönül insanı, bir Yesevî yolcusu olarak yaşamış ve bu yolda eserler vermiştir. Yakupoğlu minyatürlerinin özgün yönlerinden biri de bu çalışmalarda minyatüre uygun manzumeler kullanılmasıdır Sanatkâr, minyatürlerinde Hz. Mevlânâ’dan, Klasik şiirimizin kurucularından Kütahyalı Şeyhi’den ve Fuzûlî’den beyitler kullanmıştır.
Physiotherapy Interventions in Sprain Ankle
Authors: Dewi S Kadek S Prima , Fridayani Ni Kadek Yuni
Published: December 2023

Background: An ankle sprain is an injury to the joint, with a tear in the ligament due to excessive, and repetitive joint stretching. In general, sprains are caused by falls, slips, or pressure on the body that causes cartilage to cause problems in the feet. Ankle sprains occur due to muscle weakness and ligament laxity by exercising muscles and increasing LGS using exercise therapy, and can help improve muscle weakness caused by damage to the lateral ligament complex.
 
Objective: This study aims to summarize secondary data related to sprain ankle.
 
Methods: The research method used is a literature study using secondary data in the form of journals related to the sprain ankle topic obtained through Google Scholar, Science Direct, and PubMed.
 
Results: Several studies have shown that someone with ankle sprains can be given physiotherapy according to their condition.
 
Conclusion: Based on the results of the literature review, it can be said that someone who has an ankle sprain can experience pain and a decrease in LGS.
Efektivitas Pemberian Intervensi Fisioterapi pada Kasus De Quervain's Tenosynovitis
Authors: Ni Made Rikawiantari , Anggreni Ni Luh Putu Munia
Published: December 2023

Latar Belakang: Diperkirakan bahwa lebih dari 25% semua cedera terkait olahraga melibatkan wrist dan hand. Salah satu jenis cedera yang dapat terjadi pada regio wrist dan hand adalah De Quervain’s tenosynovitis (DQT). Penggunaan pergelangan tangan/wrist yang berlebihan dan peningkatan aktivitas yang berulang merupakan penyebab umum DQT yang mengakibatkan kerusakan mikro akibat terlalu sering tergelincirnya tendon kompartemen bagian dorsal utama, sehingga menyebabkan rasa nyeri. Penatalaksanaan konservatif pada kasus DQT berbeda berdasarkan tingkat keparahan kondisinya. Terdapat berbagai jenis intervensi fisioterapi yang dapat diterapkan pada kasus DQT, seperti pengaplikasian modalitas ultrasound therapy, low-level laser therapy, extracorporeal schock wave therapy, pemasangan splinting, kinesio taping, serta berbagai jenis exercise.

Tujuan: Untuk menentukan efektivitas pemberian intervensi fisioterapi pada kasus De Quervain’s tenosynovitis.

Metode: Metode yang digunakan pada penelitian ini adalah studi literature review yaitu menggunakan data sekunder yang diambil dari beberapa jurnal penelitian yang berkaitan dengan efektivitas intervensi fisioterapi pada kasus De Quervain’s tenosynovitis.

Hasil: Beberapa penelitian membuktikan bahwa pemberian intervensi fisioterapi berupa berupa modalitas, seperti low-level laser therapy, ultrasound therapy, extracorporeal shock wave therapy, bebera jenis latihan seperti eccentric exercise, strengthening exercise, pemasangan thumb spinting, serta pemberian manual terapi berupa deep friction massage efektif dalam mengurangi tanda dan gejala pada kasus De Quervain’s tenosynovitis.

Simpulan: Pemberian intervensi fisioterapi berupa modalitas yang dikombinasikan dengan beberapa jenis latihan, pemasangan thumb spinting, serta pemberian manual terapi berupa deep friction massage terbukti efektif dalam mengurangi gejala pada pasien dengan De Quervain’s tenosynovitis.
Physiotherapy rehabilitation management on phase IV of post-operative anterior cruciate ligament reconstruction with medial meniscus repair : a case report
Authors: Nathania Ni Putu Sukma , Vigneswari Putu Rara Kumbhara , Hasibuan Rizki Cristine , Susanto Iwan Kurnia
Published: December 2023

Background: Sports injuries are injuries that arise as a result of sporting activities or activities. 60% of sports-related injuries occur in the lower limbs, including the knee's anterior cruciate ligament (ACL). This study aims to evaluate the physiotherapy interventions to improve ROM, balance, and knee function following ACLR with medial meniscus repair phase IV.
 
Case Description: The patient complained of pain and stiffness in the popliteal area. The pain was felt when driving a car and squatting. The injury occurred when playing futsal, and the patient made a zigzag while trying to win the ball. The patient took the wrong footing. Namely, the body turned while the left leg was left behind, and the knee joint suddenly rotated or twisted. Before surgery, the patient had carried out physiotherapy for six meetings. The operation was carried out on 11 May 2022 at the Royal Progress Hospital with three-day hospitalisation. The patient has been doing physiotherapy since the first day after surgery. Currently, the patient has entered week 19 (Phase IV).
 
Conclusion: The physiotherapy rehabilitation process, in this case, focuses on maintaining and increasing the strength of the core muscles and lower extremities, preparing the patient to jog, and training the patient's brain coordination through agility training. Returning to futsal is the ultimate goal of physiotherapy rehabilitation in this case.
Covid-19, Government Initiatives, And Stock Market Liquidity: A Post-Pandemic Study From Emerging Economy- Pakistan
Authors: Muhammad Zubair Akhtar
Published: December 2023

This is post COVID-19 study which focuses on two proxies of COVID-19 and its impact on Pakistan and government initiatives' stock market liquidity and the human cost by exploring the rate of spread of COVID-19 infections. Using time-series data of the Pakistan Stock Exchange from January 2, 2020 to December 03, 2021which covers all the three waves of COVID-19 and finding suggests that an increasing (decreasing) trend in the COVID-19 confirmed cases is connected with improving (deteriorating) liquidity of Pakistan's stock market. This study concludes that policy interventions are related to stock market liquidity. Results reveal that government initiatives' control over the COVID-19 cases reduces the uncertainty among the market and investors and help policy makers for making effective policies if such kinds of uncertain diseases come again
Exploring The Nexus Between Economic Growth, Financial Development and Co2 Emission in Gulf Countries: An Application of Environmental Kuznets Curve
Authors: Majid Ibrahim Mohammed Abdullah Al Zaroon
Published: December 2023

The main objective of the current study is to investigate the impact of economic growth, financial development (both the development and shock), and energy consumption on the CO2 emission in the selected Gulf Countries. This research study incorporates financial development as the measurement of environmental quality. In this way, it will add to the existing literature. The use of NARDL has been made in this research, which is an advanced econometric approach. An efficient way of dealing with the component of asymmetry in financial development on emissions of CO2 has been provided by NARDL with reference to the economy of Gulf countries for time 1980–2014. According to the findings of the study, the financial development, energy consumptions and GDP growth are in positive and significant relationship with CO2 emission. Thus, the findings of the study are providing support to the argument broached in the study that financial development, energy consumption and economic growth are linked with CO2 emission. The study which is among the pioneering study will be helpful for policymakers, environmental economist and researchers in explaining the impact of financial development and economic growth on environmental related issues such as CO2 emission
Influence of Sensibility of Art, Mental Health Awareness, and Aesthetic Knowledge on The Painting Art Performance Among Chinese Painters
Authors: Ghulam Qambar
Published: December 2023

The main objective of the study is to examine

 the direct impact of the sensibility of art, mental health awareness, and aesthetic knowledge on the performance of printing art in China. Additionally, the study has also examined the mediating role of self-confidence. In this research. Additionally, we used an online survey to collect data from Chinese painters. The questionnaire was provided to respondents who are painting institution students or painting professionals. This research used a judgmental sampling strategy for this objective. This research used this sample strategy to disseminate a questionnaire to 487 respondents. The research had a usable response rate of 61.07 percent. A few surveys were excluded because they were incomplete. A structural equation modelling technique was used to analyses the data. The findings also provide evidence in favor of the second hypothesis of the research, which asserts that MHA has a substantial beneficial influence on PAP (Beta = 0.272, t = 3.952). In a similar fashion, SC has a significantly favourable impact on PAP (Beta = 0.268, t = 2.55). As a result, the H4 hypothesis is accepted. In addition, the correlation between SOA and PAP is positive and statistically significant (Beta=0.336, t=3.371). The finding of the study will be helpful for policymakers in formulating policies related to printing art performance in china
DETERMINANTS OF DESIGN AND BUILD CONSTRUCTION PROJECTS OF LAHORE DEVELOPMENT AUTHORITY: DOES THE PROJECT COST MATTER?
Authors: Muhammad Ahmad Awais
Published: December 2023

Construction projects are ones, that need to be handled with care, as their determinants and building factors, may relate a lot towards the economic factor of the project. One slight misunderstanding of the determinants, the design and build may be completely worn off and lead toward an economical failure. The cost matters a lot, and for that particular reason, this paper portrays the system and framework that deduced the determinants and capacity related to the construction projects, that are carried through an institute, specifically Lahore Development Authority in this case, which helps the reader to understand various factors for that might hinder the determinants and design-build capacity of any construction project. The SEM technique, that has been a part of project management works, is used as a methodological part for this paper to express the cost matter for the construction projects at LDA. Taking a sample size related to the population, preparation of the questionnaire, and their descriptive analysis towards the response of specified population to the questionnaire designed, which will further lead to an answer of that modeling equation, and helps to evaluate the determinants that might hinder or effect the cost of project management.