bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards Mannosylerythritol Lipids (MELs) for Bioremediation: Effects of NaCl on M. antarcticus Physiology and Biosurfactant and Lipid Production; Ecotoxicity of MELs
Authors: Keković Petar , Borges Margarida , Faria Nuno Torres , Ferreira Frederico Castelo
Published: November 2022

Mannosylerythritol lipids (MELs) are a group of biosurfactants with a wide range of potential applications, due to their excellent tensioactive properties, biocompatibility, and biodegradability. One of the envisioned uses for MELs is in bioremediation in marine and terrestrial environments. However, knowledge regarding their ecotoxicity is limited. The current costs of production for this biosurfactant are too high to make it competitive in the surfactant market. In an effort to facilitate the use of MELs for marine bioremediation purposes, their production using sea water in medium formulation was explored. Cells were exposed to different levels of NaCl during fermentation, and the effects of increased salinity on the cells and their performance was monitored. In addition, cells were briefly exposed to an osmotic shock, by introducing pure NaCl into the broth, to measure their physiological response. Although the overall effect of NaCl in the medium was negative, cells produced more lipases in these stress conditions. Furthermore, the changes triggered by the osmotic shock caused changes in the cell surface and affected their hydrophobicity, reducing the levels of MELs adsorbed to the cells, which in turn led to an increase in formation of MEL-rich beads. Marine-level salinity (3.5%) was found to be sufficient to enable production of MELs in unsterile conditions and inhibited an introduced bacterial contaminant. Finally, the toxicity levels of MELs to a model marine organism and plant model were lower than other biosurfactants and that of a commercial chemical dispersant used for bioremediation.
Distributed Robust Fast Finite-Time Formation Control of Underactuated ASVs in Presence of Information Interruption
Authors: Zhang Guoqing , Han Jun , Li Jiqiang , Zhang Xianku
Published: November 2022

To adapt to complex navigation conditions, this paper addresses the coordination formation of autonomous surface vehicles (ASVs) with the constraint of information interruption. For this purpose, a distributed robust fast finite-time formation control algorithm is proposed by fusion of the directed graph and neural network method. In the strategy, the graph theory is utilized for the channel of information transmission to maintain the stability of the formation system. In addition, the radial basic function (RBF) neural network is employed to approximate the structure uncertainty. Due to the merits of the robust neural damping technique, only two adaptive parameters are designed to compensate the perturbation from the model uncertainty and external environmental. Furthermore, an improved dynamic surface control (DSC) technology is developed for constituting the exponential term of the Lyapunov function. It is proven that the proposed scheme is able to achieve consensus tracking in finite time quickly, and the errors rapidly approach a small region around the origin. Finally, the feasibility and effectiveness of the algorithm are verified by two numerical simulations.
The Potential Role of Dysregulated miRNAs in Adolescent Idiopathic Scoliosis and 22q11.2 Deletion Syndrome
Authors: Montemurro Nicola , Ricciardi Luca , Scerrati Alba , Ippolito Giorgio , Lofrese Giorgio , Trungu Sokol , Stoccoro Andrea
Published: November 2022

Background: Adolescent idiopathic scoliosis (AIS), affecting 2–4% of adolescents, is a multifactorial spinal disease. Interactions between genetic and environmental factors can influence disease onset through epigenetic mechanisms, including DNA methylation, histone modifications and miRNA expression. Recent evidence reported that, among all clinical features in individuals with 22q11.2 deletion syndrome (DS), scoliosis can occur with a higher incidence than in the general population. Methods: A PubMed and Ovid Medline search was performed for idiopathic scoliosis in the setting of 22q11.2DS and miRNA according to PRISMA guidelines. Results: Four papers, accounting for 2841 individuals, reported clinical data about scoliosis in individuals with 22q11.2DS, showing that approximately 35.1% of the individuals with 22q11.2DS developed scoliosis. Conclusions: 22q11.2DS could be used as a model for the study of AIS. The DGCR8 gene seems to be essential for microRNA biogenesis, which is why we propose that a possible common pathological mechanism between scoliosis and 22q11.2DS could be the dysregulation of microRNA expression. In the current study, we identified two miRNAs that were altered in both 22q11.2DS and AIS, miR-93 and miR-1306, thus, corroborating the hypothesis that the two diseases share common molecular alterations.
Ecophysiological Effects of Groundwater Drawdown on Phreatophytes: Research Trends during the Last Three Decades
Authors: Hernandez Jonathan O.
Published: November 2022

A systematic synthesis of phreatophytes’ responses to groundwater drawdown would provide a more complete picture of groundwater-related research aimed at the sustainable management of groundwater-dependent ecosystems amid climate change. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the ecophysiological effects of groundwater drawdown on phreatophytes and methodological approaches were synthesized from peer-reviewed articles published from 1988 to 2022. The highest relative count of studies was found in arid and semi-arid high-income countries, such as Australia and North America (18–24%), while the lowest relative count to no data was found in hyper-arid countries, such as north African countries (0–3.65%). The groundwater depth effects on phreatophyte ecophysiology had the highest relative count (53.65%), followed by large-scale tree plantation effects on the groundwater characteristics (44.37%) and groundwater depth and biological invasion relationship (1.99%). The results revealed that as the groundwater depth increased, the phreatophytic vegetation growth, productivity, and community structure decreased across the ecosystem types. A groundwater withdrawal also had a significant impact on the physiology of the phreatophytes, specifically on the transpiration rate, xylem water potential, hydraulic conductance, and photosynthetic rate. Many of the reviewed studies concluded that large-scale tree plantations can deplete groundwater resources due to an increased evapotranspiration rate. Further, species’ diversity, evenness, dominance, composition, and distribution, as well as the Normalized Difference Vegetation Index (NDVI), are commonly measured parameters in the reviewed studies through vegetation and groundwater monitoring. Amid applied and contemporary problems, this synthesis may provide researchers with cues to conduct studies relevant to the integrated and sustainable conservation and management of groundwater-dependent ecosystems, particularly in data-poor, hyper-arid countries.
The Effects of Place Attachment and Emotional Solidarity on Community Residents’ Attitudes toward Glacier Tourism
Authors: Ge Qiuling , Yang Jianping , Tang Fan , Wang Yanxia , He Qingshan , Chen Hongju , Ji Qin , Ding Feng , Jiang Yang , Wang Yejuan
Published: November 2022

The perceptions and attitudes of community residents are a “mirror” of tourism development. Little research has been conducted on the effects of place attachment and emotional solidarity on community residents’ attitudes toward tourism in China’s glacier tourism-related areas. In this paper, we selected the southernmost marine glacier in China, Hailuogou Glacier Forest Park, as a case study, and constructed a structural equation model of residents’ tourism perceptions and attitudes based on 358 valid questionnaires obtained from fieldwork. We analyzed the logical connection and influencing relationship between place attachment, residents’ perceptions (residents’ benefits and environmental perceptions), and community residents’ attitudes (security, support, satisfaction), and explored countermeasures and suggestions for building a harmonious host–customer relationship in the Hailuogou area to improve glacier tourism. The results of the study show that the influence of place attachment and residents’ perceptions on emotional solidarity is different from the degree of influence of emotional solidarity on residents’ tourism attitudes, with the most significant positive influence of place attachment on emotional solidarity and the greatest influence of emotional solidarity on sense of security. Emotional solidarity had a certain mediating effect between place attachment, residents’ perceptions, and residents’ tourism attitudes. Significantly, emotional solidarity had the most fully mediated effect between place attachment and support, reaching 73.61%. The moderating effect of place attachment reflects that the higher the place attachment, the weaker the correlation between residents’ perceptions and residents’ tourism attitudes. Meanwhile, residents’ tourism attitudes will weaken their influence with the increase in emotional solidarity. Based on the above results, relevant suggestions are made to provide a theoretical basis and decision-making reference for the development and management of glacier tourism destinations.
Structure and Phylogeny of Chloroplast and Mitochondrial Genomes of a Chlorophycean Algae Pectinodesmus pectinatus (Scenedesmaceae, Sphaeropleales)
Authors: Zhao Xinmei , Liu Chenglong , He Lijuan , Zeng Zhiyong , Zhang Anda , Li Hui , Hu Zhangli , Lou Sulin
Published: November 2022

Pectinodesmus pectinatus is a green alga of commercial interest in sewage purification. Clarification of its organelle genomes is helpful for genetic manipulation, taxonomic revisions and evolutionary research. Here, de novo sequencing was used to determine chloroplast genome and mitochondrial genome of P. pectinatus strain F34. The chloroplast genome was composed of a large single-copy (LSC) region of 99,156 bp, a small single-copy (SSC) region of 70,665 bp, and a pair of inverted repeats (IRs) with a length of 13,494 bp each separated by LSC and SSC. The chloroplast genome contained 69 protein-coding genes, 25 transfer-RNA (tRNA) genes, 3 ribosomal RNA (rRNA) genes. The mitochondrial genome was 32,195 bp in length and consisted of 46 unique genes, including 16 protein-coding genes, 27 tRNA genes and 3 rRNA genes. The predominant mutations in organelle genomes were T/A to G/C transitions. Phylogenic analysis indicated P. pectinatus was a sister species to Tetradesmus obliquus and Hariotina sp. within the Pectinodesmus genus. In analysis with CGView Comparison Tool, P. pectinatus organelle genomes displayed the highest sequence similarity with that of T. obliquus. These findings advanced research on the taxonomy and phylogeny of Chlorophyceae algae and particularly revealed the role of P. pectinatus in microalgae evolution.
Effects of Supplementing Quails’ (Coturnix japonica) Diets with a Blend of Clove (Syzygium aromaticum) and Black Cumin (Nigella sativa) Oils on Growth Performance and Health Aspects
Authors: Majrashi Kamlah Ali
Published: November 2022

In an attempt to discover a safe growth promoter and partial alternative for antibiotics, this existing study explores the efficacy of using assorted levels of cold-pressed oil mixtures consisting of 1:1 clove and black cumin (Nigella sativa) oils (CLNS) against the indices of growth and carcass traits, as well as blood components of growing Japanese quails. In a complete randomized design, three hundred growing unsexed Japanese quails (one week of age) were included in this experiment. The treated groups were as follows: (1) control basal diet (CLNS0), (2) basal diet + 1.50 mL CLNS/kg diet (CLNS1.5), and (3) basal diet + 3.00 mL CLNS/kg diet (CLNS3). The results showed that supplementing the diet with a 3.00 mL CLNS/kg diet insignificantly improved body weight (BW) compared with the CLNS0 and CLNS1.5 groups. A significantly (p < 0.05) higher feed intake and feed conversion ratio—FCR— (deterioration of feed conversion) were reported after the addition of CLNS. Feeding the quails on a 3.00 mL CLNS/kg enriched-diet yielded superior values of dressing percentage, carcass yield, and breast and thigh relative weights compared to other groups. A significant decline was noticed in creatinine and BUN levels in birds fed a 1.50 and 3.00 mL CLNS/kg diet compared with the CLNS0 group The liver enzymes and total bilirubin activities showed insignificant effects in quails fed CLNS-enriched diets. The total protein and globulins concentrations presented a significant augment in quails that received CLNS. The antiradical activity of CLNS supplementation showed increases in hepatic reduced glutathione (GSH) activity and the levels of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase, glutathione S transferase (GST), and glutathione reductase (GR) in birds. The concentration of MDA in hepatic homogenates that received CLNS-diets was significantly decreased compared with the control quails. These findings clarified that the dietary inclusion of CLNS can enhance the growth performance and antioxidative status of growing Japanese quails.
Human Papillomavirus (HPV) Infection and Its Impact on Male Infertility
Authors: Capra Giuseppina , Notari Tiziana , Buttà Michela , Serra Nicola , Rizzo Giovanni , Bosco Liana
Published: November 2022

Nowadays, the striking numbers of infertile couples that turn to assisted reproductive technologies (ART) drive the research toward a more comprehensive understanding of the underlying causes. Male factors contribute to the inability to conceive in half of the cases, and it has been suggested that sexually transmitted infections could have a role in the onset of spermatozoa impairments. Since the impact of HPV infection on sperm quality and sperm DNA integrity is debated, we wanted to analyze its impact on conventional seminal parameters and the sperm DNA fragmentation index (DFI). Therefore, 117 semen samples of patients undergoing IVF were evaluated for the following characteristics: HPV DNA detection and sperm DNA fragmentation, concentration, motility, and morphology. The results showed a higher rate of HPV-negative patients (59.8% vs. 40.2%) and no HPV-related effect on DFI, sperm concentration, total sperm number, and total motility. Only progressive motility and morphology were found as significantly influenced by HPV positivity. Moreover, we observed a statistically significant difference in DFI when comparing high-risk HPV (HR-HPV) and low-risk HPV (LR-HPV) genotypes. Our data suggest that the presence of any HPV type, whatever the exact localization of the virions, can impair some sperm parameters, while HR-HPVs specifically affect the integrity of spermatozoa DNA.
Study on Electromagnetic Performance of La0.5Sr0.5CoO3/Al2O3 Ceramic with Metal Periodic Structure at X-Band
Authors: Yang Zhaoning , Gao Lu , Ren Wei , Zhang Ruiduan , Chen Yangyang , Zhou Qian , Sun Kai , Jie Ziqi , Jia Yanmin
Published: November 2022

A radar absorbing material (RAM) is designed by combining the La0.5Sr0.5CoO3/Al2O3 ceramic and the metal periodic structure. The phase constitution and the microscopic morphology of the La0.5Sr0.5CoO3/Al2O3 ceramic are examined, respectively. The electrical properties and magnetic properties of the La0.5Sr0.5CoO3/Al2O3 ceramic are also measured at the temperature range of 25~500 °C. Based on the experimental and simulation results, the changes in the reflection loss along with the structure parameters of RAM are analyzed at 500 °C. The analytical results show that the absorption property of the RAM increases with the increase in the temperature. When the thickness of the La0.5Sr0.5CoO3/Al2O3 ceramic is 1.5 mm, a reflection loss <−10 dB can be obtained in the frequency range from approximately 8.2 to 16 GHz. More than 90% microwave energy can be consumed in the RAM, which may be applied in the high temperature environment.
Characterization of Transparent Fluorapatite Ceramics Fabricated by Spark Plasma Sintering
Authors: Furuse Hiroaki , Kato Daichi , Morita Koji , Suzuki Tohru S. , Kim Byung-Nam
Published: November 2022

Highly optically transparent polycrystalline fluorapatite ceramics with hexagonal crystal structures were fabricated via a liquid-phase synthesis of fluorapatite powder, followed by spark plasma sintering (SPS). The effect of sintering temperature, as observed using a thermopile, on the optical transmittance and microstructure of the ceramics was investigated in order to determine suitable sintering conditions. As a result, high optical transmittance was obtained in the SPS temperature range of 950–1100 °C. The highest optical transmittance was obtained for the ceramic sample sintered at 1000 °C, and its average grain size was evaluated at only 134 nm. The grain size dramatically increased with temperature, and the ceramics became translucent at SPS temperatures above 1200 °C. The mechanical and thermal properties of the ceramics were measured to evaluate the thermal shock parameter, which was found to be comparable to or slightly smaller than that of single-crystal fluorapatite. This transparent polycrystalline fluorapatite ceramic material should prove useful in a wide range of applications, for example as a biomaterial or optical/laser material, in the future. Furthermore, the knowledge obtained in this study should help to promote the application of this ceramic material.
Investigating Microstructural Evolution and Its Influence on Tribological Behaviors of In-Situ Formed VCp Reinforced Iron-Based Composites with Variable Mn Content
Authors: Chen Pinghu , Zhao Wenguang , Liu Zhen , Zhang Yun , Weng Caifeng , Li Ruiqing , Chen Yong
Published: November 2022

In this work, we fabricated VCp-reinforced iron-based composites (VCFCs) by adjusting the amount of Mn elements and investigated how the concentration of Mn affected the microstructural characteristics of Vanadium carbide (VC) and the texture of the iron matrix, and the influence of microstructure on tribological behaviors should be investigated. We demonstrated that VC changed from thick dendrite crystals (~50 μm) to tiny equiaxed crystals (~5 μm). Furthermore, the nucleation mechanism of VC also transformed from homogeneous nucleation to heterogeneous nucleation due to the lower Gibbs free energy of TiC and the tailoring effect of the Mn elements. In addition, γ-Fe in the FCC structure gradually increased and ascribed an increase of Mn content to the lower transformation temperature of martensite. Furtherly, particulate features and phase constitution could contribute to hardness and wear resistance. Higher hardness and excellent wear resistance occurred in the 3.0 Mn sample, which had a hardness of 869 HV and a wear rate of 1.77 × 10−6 mm3/(N·m). In addition, the adhesive wear could be the main wear mechanism in the 3.0 Mn sample, while the abrasive wear could be in the 4.5 Mn sample.
Centrifugal Atomization of Glass-Forming Alloy Al86Ni8Y4.5La1.5
Authors: Pijuan Jordi , Cegarra Sasha Alejandra , Dosta Sergi , Albaladejo-Fuentes Vicente , Riera María Dolores
Published: November 2022

Centrifugal atomization is a rapid solidification technique for producing metal powders. However, its wide application has been limited to the production of common metal powders and their corresponding alloys. Therefore, there is a lack of research on the production of novel materials such as metallic glasses using this technology. In this paper, aluminum-based glassy powders (Al86Ni8Y4.5La1.5) were produced by centrifugal atomization. The effects of disk speed, atomization gas, and particle size on the cooling rate and the final microstructure of the resulting powder were investigated. The powders were characterized using SEM and XRD, and the amorphous fractions of the atomized powder samples were quantified through DSC analysis. A theoretical model was developed to evaluate the thermal evolution of the atomized droplets and to calculate their cooling rate. The average cooling rate experienced by the centrifugally atomized powder was calculated to be approximately 7 × 105 Ks−1 for particle sizes of 32.5 μm atomized at 40,000 rpm in a helium atmosphere. Amorphous fractions from 60% to 70% were obtained in particles with sizes of up to 125 μm in the most favorable atomization conditions.
Defect Detection and Characterization in Concrete Based on FEM and Ultrasonic Techniques
Authors: Kim Jeongnam , Cho Younho , Lee Jungwon , Kim Young H.
Published: November 2022

In order to estimate the crack depth in concrete using time-of-flight, finite element analysis and experiments were performed on non-cracked concrete blocks and 45 mm and 70 mm vertical cracks. As a result of measuring the time-of-flight change by changing the positions of the transmitter and receiver, it was confirmed that the finite element analysis results agreed with the experimental results, and high accuracy was confirmed by various formulas for calculating the depth of defects using the obtained experimental measurements for comparison. In addition to the verification of the simulation and experimental theory, research was conducted through actual field cases, and methodologies for crack detection and depth evaluation for concrete structures were presented, and furthermore, the expected effects of improving the soundness and safety of structures were shown.
Palladium/Graphene Oxide Nanocomposite for Hydrogen Gas Sensing Applications Based on Tapered Optical Fiber
Authors: Alkhabet Mohammed Majeed , Yaseen Zaher Mundher , Eldirderi Moutaz Mustafa A. , Khedher Khaled Mohamed , Jawad Ali H. , Girei Saad Hayatu , Salih Husam Khalaf , Paiman Suriati , Arsad Norhana , Mahdi Mohd Adzir , Yaacob Mohd Hanif
Published: November 2022

Gaseous pollutants such as hydrogen gas (H2) are emitted in daily human activities. They have been massively studied owing to their high explosivity and widespread usage in many domains. The current research is designed to analyse optical fiber-based H2 gas sensors by incorporating palladium/graphene oxide (Pd/GO) nanocomposite coating as sensing layers. The fabricated multimode silica fiber (MMF) sensors were used as a transducing platform. The tapering process is essential to improve the sensitivity to the environment through the interaction of the evanescent field over the area of the tapered surface area. Several characterization methods including FESEM, EDX, AFM, and XRD were adopted to examine the structure properties of the materials and achieve more understandable facts about their functional performance of the optical sensor. Characterisation results demonstrated structures with a higher surface for analyte gas reaction to the optical sensor performance. Results indicated an observed increment in the Pd/GO nanocomposite-based sensor responses subjected to the H2 concentrations increased from 0.125% to 2.00%. The achieved sensitivities were 33.22/vol% with a response time of 48 s and recovery time of 7 min. The developed optical fiber sensors achieved excellent selectivity and stability toward H2 gas upon exposure to other gases such as ammonia and methane.
Diffusing Mn4+ into Dy3+ Doped SrAl2O4 for Full-Color Tunable Emissions
Authors: Zhai Bao-gai , Chen Meng Meng , Huang Yuan Ming
Published: November 2022

Dy3+ and Mn4+ codoped SrAl2O4 (SrAl2O4:Dy3+,Mn4+) phosphors were obtained by diffusing Mn4+ ions into Dy3+-doped SrAl2O4 via the constant-source diffusion technique. The influences of diffusion temperature and diffusion time on the emissions of SrAl2O4:Dy3+,Mn4+ were investigated. It was found that: (i) efficient red emission peaking at 651 nm can be readily achieved for SrAl2O4:Dy3+ by simply diffusing Mn4+ into SrAl2O4:Dy3+ at 800 °C and above; (ii) the red emission of Mn4+ becomes dominant over the characteristic emissions of Dy3+ when the diffusion temperature is 900 °C or higher; and (iii) the intensity of the red emission of SrAl2O4:Dy3+,Mn4+ is far more sensitive to diffusion temperature than to diffusion time. Our results have demonstrated that full-color tunable emissions can be realized for SrAl2O4:Dy3+, Mn4+ by tuning the parameters of diffusion temperature and diffusion time, which opens up a space for realizing easy color control of Dy3+-doped inorganic materials.
Magnetic Zinc Oxide/Manganese Ferrite Composite for Photodegradation of the Antibiotic Rifampicin
Authors: Duarte Filipe da Silva , Melo Amanda Lys Matos dos Santos , Ferro Alice de Barros , Zanta Carmem Lúcia de Paiva e Silva , Duarte José Leandro da Silva , Oliveira Rosane Maria Pessoa Betânio
Published: November 2022

In this study, a composite of zinc oxide and manganese ferrite was synthesized using co-precipitation and hydrothermal routes, to be used as photocatalysts in reactions with UV/Vis light source. The synthesized materials were characterized by FTIR, XRD, and SEM, where it was possible to verify the efficiency of the syntheses performed, through the identification of the resulting phases, the evaluation of the structural morphology of the particles, and the analysis of the detachments of the main vibration bonds present in these materials. The composite ZnO/MnFe2O4 was used in photodegradation reactions of the antibiotic rifampicin, with catalyst dosage of 0.20; 0.40, and 0.60 g and 10 ppm of rifampicin, reactions using pure ZnO as a catalyst were also performed as a comparative parameter of the influence of MnFe2O4 in this system. The composite ZnO/MnFe2O4 showed a maximum percentage of rifampicin decontamination of 94.72% and ZnO, 74.20%using 0.20 g of photocatalyst after 90 min, which indicates a positive influence on this process. The solution treated with ZnO/MnFe2O4 was subjected to magnetic field induction for attraction and consequently accelerated removal of the solids present, successfully, compacting for the application of ZnO/MnFe2O4 to be presented as a promising material for decontamination of emerging pollutants through photocatalytic reactions.
A Study on the Preparation and Cavitation Erosion Mechanism of Polyether Polyurethane Coating
Authors: Su Qiong , Wang Tiancong , Hou Guoliang , Cui Haixia , Chen Lei , An Yulong , Zhou Huidi , Chen Jianmin
Published: November 2022

Polyurethane elastomers are anticipated to be applied in the field of cavitation erosion (CE) resistance, but their protection and damage mechanisms are not clear, which greatly restricts their further development. In this article, five polyether polyurethanes (PUx) with different crosslinking densities were prepared. Their mechanical properties, thermal properties, water absorption, surface morphology and chemical structure before and after CE tests were compared with ESEM, OM, TG-DSC, FTIR and XPS in detail. The results showed that with an increase in crosslinking density, the tensile strength of PUx increased first and then decreased, elongation at break and water absorption reduced gradually and thermal decomposition temperature and adhesion strength increased steadily. During the CE process, cavitation load aggravated the degree of microphase separation and made brittle hard segments concentrate on the coating surface; meanwhile, cavitation heat accelerated hydrolysis, pyrolysis, oxidation and the fracture of molecular chains. As a result, the mechano-thermal coupling intensified the formation and propagation of fatigue cracks, which should be the fundamental reason for the CE damage of polyurethane elastomer. PU0.4 exhibited the best CE resistance among the five coatings thanks to its good comprehensive properties and may find potential applications on the surface of hydraulic components.
Influence of Different Reflux Groove Structures on the Flow Characteristics of the Roots Pump
Authors: Xing Wenshuai , Zhang Fan , Zhao Feifei , Song Jialong , Zhu Xiumei , Tang Xingpeng
Published: November 2022

A Roots pump often exhibits the typical characteristics of high gas pressure in the exhaust port, low pressure at a basic volume and large airflow pulsation at the outlet as a result of gas reflux. In light of this, this study employed Pumplinx software for the numerical calculation of the entire flow field of a two-bladed Roots pump. The effects of the rectangular and curved reflux groove structures on the internal flow field of a Roots pump, especially on the outlet pressure pulsation and flow rate, were unveiled separately. The rectangular reflux groove controlled the angle and thickness, while the curved reflux groove regulated the coordinates of the key points on the Bezier curve. It is worth recognizing that different reflux groove structures were not noticeable in enhancing the inlet measurement flow pattern; reduce the exhaust pressure pulsation, flow pulsation and exhaust section vortex. Interestingly, the rectangular return groove far outweighed the curved groove when optimizing the pressure and flow pulsation when registering the higher flow loss compared to the curved return groove. The merits and demerits of the Q criterion and omega criterion in characterizing the vortex structure of the flow field in the Roots pump were compared by Tecplot software. The omega criterion looked more robust, clear and continuous in revealing the strong and weak vortices in the Roots pump. The outcome of this research work could provide a reference for the study of Roots pump airflow pulsation, vortex analysis and casing structure design optimization.
A Fast Globally Convergent Particle Swarm Optimization for Defect Profile Inversion Using MFL Detector
Authors: Lu Senxiang , Liu Jinhai , Wu Jing , Fu Xuewei
Published: November 2022

For the problem of defect inversion in magnetic flux leakage technology, a fast, globally convergent particle swarm optimization algorithm based on the finite-element forward model is introduced as an inverse iterative algorithm in this paper. Two aspects of the traditional particle swarm optimization algorithm have been improved: self-adaptive inertia weight and speed updating strategy. For the inertia weight, it can be adaptively adjusted according to the particle position. The speed update strategy mainly uses the best experience positions of other particles in a randomly selected population to realize the algorithm’s learning. At the same time, the learning factor of the position variable is designed to change with the number of iteration steps. The particle with a good position is added to jump out of the local minimum and accelerate the optimization process. Through the comparison experiment, the improved particle swarm optimization algorithm has a faster convergence speed compared with other traditional particle swarm optimization algorithms. It is more difficult for it to fall into the local minimum value and it is more easily converted to a higher precision.
Digitising a Machine Tool for Smart Factories
Authors: Averyanov Anton , Aheleroff Shohin , Polzer Jan , Xu Xun
Published: November 2022

Smart factory development renders an incredible opportunity for the manufacturing industry to join the Fourth Industrial Revolution (Industry 4.0). However, an incredible number of conventional CNC machine tools are populating the world’s factories. Replacing these machines is an expensive process. This task might be considered unliftable by most small businesses. An inexpensive digitalisation of Machine Tool 3.0 to an Industry 4.0-compatible tool might be one way for small businesses to keep up with the progress and stay competitive. The developed framework uses recent advances in the open-source community to transform a conventional CNC machine into Machine Tool 4.0. The suggested approach opens up a way to bypass the proprietary computer numerical control and enable connectivity and efficient data communication with the machine tool. At almost no cost, the provided strategy converts an average CNC machine into a machine tool with the full spectrum of accessibility and interoperability of Machine Tool 4.0. The proposed solution can enable small- and medium-sized enterprises to step up and propel them into the Industry 4.0 era.
Carbonic Anhydrase Inhibitors from Marine Natural Products
Authors: Supuran Claudiu T.
Published: November 2022

Carbonic anhydrases (CAs, EC 4.2.1.1) are widespread metalloenzymes in organisms in all life kingdoms, being involved in pH regulation, metabolic processes and many other physiological and pathological conditions. CA inhibitors and activators thus possess applications as pharmacological agents in the management of a range of diseases. Marine natural products have allowed the identification of some highly interesting CA inhibitors, among which are sulfonamides, phenols, polyamines, coumarins and several other miscellaneous inhibitors, which are reviewed here. Psammaplin C and some bromophenols were the most investigated classes of such marine-based inhibitors and have been used as lead molecules for developing interesting types of potent and, in some cases, isoform-selective inhibitors, with applications as antitumor agents by inhibiting human CA XII and P-glycoprotein activities. Some phenols have shown interesting bacterial and fungal β-CA inhibitory effects. Marine natural products thus constitute a gold mine for identifying novel CA inhibitors, some of which may lead to the development of novel types of pharmacological agents.
Quality of Life, Anxiety and Depression in Women Treated with Hysteroscopic Endometrial Resection or Ablation for Heavy Menstrual Bleeding: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Vitale Salvatore , Riemma Gaetano , Mikuš Mislav , Carugno Jose , Torella Marco , Reyes-Muñoz Enrique , Cela Vito , Perez Medina Tirso , Della Corte Luigi , Pacheco Luis , Haimovich Sergio , De Franciscis Pasquale , Angioni Stefano
Published: November 2022

Background and Objectives: Hysteroscopic endometrial resection (ER) or global endometrial ablation (GEA) are feasible methods to treat heavy menstrual bleeding (HMB). The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) was to assess patient’s quality of life (QoL) in women treated with ER/GEA compared to hysterectomy. Materials and Methods: Electronic searches in MEDLINE Scopus, ClinicalTrials.gov, EMBASE, PROSPERO and Cochrane CENTRAL were conducted from their inception to July 2022. Inclusion criteria were RCTs of premenopausal women with HMB randomized to conservative surgical treatment (ER/GEA) or hysterectomy. The primary outcome was the evaluation of QoL using the SF-36 score. Results: Twelve RCTs (2773 women) were included in the analysis. Women treated with hysteroscopic ER/GEA showed significantly lower scores for the SF-36 general health perception (mean difference (MD) −8.56 [95% CI −11.75 to −5.36]; I2 = 0%), social function (MD −12.90 [95% CI −23.90 to −1.68]; I2 = 91%), emotional role limitation (MD −4.64 [95% CI −8.43 to −0.85]; I2 = 0%) and vitality (MD −8.01 [95% CI −14.73 to −1.30]; I2 = 74%) domains relative to hysterectomy. Anxiety, depression scores and complication rates were similar between treatments. Relative to uterine balloon therapy, amenorrhea was more common with EA/GER (relative risk 1.51 [95% CI 1.03 to 1.20] I2 = 28%), but posttreatment satisfaction was similar. Conclusions: Women’s perception of QoL might be seen to be less improved after hysteroscopic ER/GEA rather than hysterectomy. However, such findings need to be confirmed by additional trials due to the high number of outdated studies and recent improvements in hysteroscopic instrumentation and techniques.
Pseudophakic Cystoid Macular Oedema (PCME) Prevention in Patients with Non-Proliferative Diabetic Retinopathy (NPDR)—Randomized Controlled Trial
Authors: Jukić Anđela , Kasalica Žužul Rajka , Pavan Josip , Lovrić Mila , Kozmar Ana , Plavec Davor , Kuzman Tomislav , Kalauz Miro , Jukić Tomislav
Published: November 2022

Background and Objectives: The purpose of this study was to compare the effect of topical bromfenac and dexamethasone on the intraocular concentration of interleukin 6 (IL-6) and incidence of pseudophakic cystoid macular oedema (PCME) after cataract surgery in patients with non-proliferative diabetic retinopathy (NPDR). Materials and Methods: Ninety eyes of patients with mild-to-moderate NPDR that underwent phacoemulsification cataract surgery were divided into three groups. A detailed description of the clinical study protocol is described later in paper. In short, Group 1 received topical bromfenac (0.9 mg/mL), Group 2 dexamethasone (1 mg/mL), and Group 3 placebo, both preoperatively and postoperatively. Additionally, all patients received combined topical steroid and antibiotic drops (dexamethasone, neomycin and polymyxin B) 3 weeks postoperatively. On the day of the surgery, aqueous humour samples (0.1–0.2 mL) were obtained and IL-6 concentrations were analysed. Central foveal subfield thickness (CFT) measured using spectral-domain optical coherence tomography (SD-OCT) was analysed preoperatively and postoperatively. Results: There was no significant difference in IL-6 concentrations between groups. Postoperative CFT was significantly lower in the dexamethasone group compared to the placebo group. In addition, the correlation between IL-6 and CFT was statistically significant in the dexamethasone group. No patient developed PCME in any of the three groups. No adverse events were reported during the study. Conclusion: Topical bromfenac and dexamethasone have no significant effect on intraocular IL-6 concentration in patients with NPDR. Topical bromfenac is not more effective than topical dexamethasone in reducing postoperative CFT in patients with NPDR.
Neurodevelopmental Outcomes among Brazilian Children with Cyanotic Congenital Heart Disease and Its Associated Factors
Authors: Vignol Flávia Saraçol , Aikawa Priscila , da Silveira Tatiane Britto , Tavella Ronan Adler , Mahtani-Chugani Vinita , Sanz Emílio J. , da Silva Júnior Flavio Manoel Rodrigues
Published: November 2022

Objectives: The aim of this study was to evaluate neurodevelopmental outcomes (motor development, nonverbal intelligence, and attention) in children with cyanotic congenital heart disease (CHD) compared with healthy children from a public hospital in southern Brazil. Materials and Methods: This was a cross-sectional study with pediatric patients of both sexes: 37 children with cyanotic CHD and a control group with 38 healthy children. Parents/guardians undertook a questionnaire and the SNAP IV scale (to evaluate attention) was applied. Two instruments were applied to each child: the R-2 Non-Verbal Intelligence test and the motor development scale. To assess the factors associated with insufficient performance in the three fields of neurodevelopment, a Poisson regression analysis was performed with a robust estimate. Results: There were no significant differences between children with cyanotic CHD and the control group for any of the neurodevelopmental outcomes studied. Low socioeconomic class was a factor associated with worse performance on the intelligence test and inattention. Furthermore, age was a factor for performance on the intelligence test, while a greater number of siblings was a factor associated with worse performance on the attention test. Conclusions: Public policies regarding child health must involve prioritizing the improvement of families’ social conditions.
The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models
Authors: Chioccioli Altadonna Ginevra , Montalbano Alberto , Iorio Jessica , Becchetti Andrea , Arcangeli Annarosa , Duranti Claudia
Published: November 2022

Ion channels are implicated in various diseases, including cancer, in which they modulate different aspects of cancer progression. In particular, potassium channels are often aberrantly expressed in cancers, a major example being provided by hERG1. The latter is generally complexed with β1 integrin in tumour cells, and such a molecular complex represents a new druggable hub. The present study focuses on the characterization of the functional consequences of the interaction between hERG1 and β1 integrins on different substrates over time. To this purpose, we studied the interplay alteration on the plasma membrane through patch clamp techniques in a cellular model consisting of human embryonic kidney (HEK) cells stably transfected with hERG1 and in a cancer cell model consisting of SH-SY5Y neuroblastoma cells, endogenously expressing the channel. Cells were seeded on different substrates known to stimulate β1 integrins, such as fibronectin (FN) for HEK-hERG1 and laminin (LMN) for SH-SY5Y. In HEK cells stably overexpressing hERG1, we observed a hERG1 current density increase accompanied by Vrest hyperpolarization after cell seeding onto FN. Notably, a similar behaviour was shown by SH-SY5Y neuroblastoma cells plated onto LMN. Interestingly, we did not observe this phenomenon when plating the cells on substrates such as Bovine Serum Albumin (BSA) or Polylysine (PL), thus suggesting a crucial involvement of ECM proteins as well as of β1 integrin activation.
Effect of Secondary Phases on Multi-Step Phase Transitions and Magnetocaloric Properties in MnFe-Based Alloys
Authors: Lee A-Young , Lee Min-Ha , Kim Song-Yi , Han JunHee , Kang Ki-Hoon , Kim Jong-Woo
Published: November 2022

This study investigated the effect of the secondary phases on multi-step phase transitions and the magnetocaloric properties depending on the Ge content in the MnFeCoPSiGe alloys. Two-step phase transitions were observed by the variations of the Fe2P-type hexagonal structure (first-order) and secondary phases (second-order). The Curie temperature alters with non-linear behavior consistent with change of the lattice parameters. In addition, the magnetic entropy change decreased with the increase of the Ge content and, subsequently, fractions of the secondary phases. However, the morphological variation of microstructure, distributed as a circular-type shape of the Fe2P-type hexagonal structure in the Ge-rich matrix, increased the magnetic entropy change. Therefore, the addition of Ge enables the control of the Curie temperature to be applicable for high temperature operating devices. The control of the secondary phases and morphology of the microstructure are crucial to improve the phase transition and magnetic entropy change.
Harmonization of Rapid Evaporative Ionization Mass Spectrometry Workflows across Four Sites and Testing Using Reference Material and Local Food-Grade Meats
Authors: Kaufmann Martin , Vaysse Pierre-Maxence , Savage Adele , Amgheib Ala , Marton András , Manoli Eftychios , Fichtinger Gabor , Pringle Steven D. , Rudan John F. , Heeren Ron M. A. , Takáts Zoltán , Balog Júlia , Porta Siegel Tiffany
Published: November 2022

Rapid evaporative ionization mass spectrometry (REIMS) is a direct tissue metabolic profiling technique used to accurately classify tissues using pre-built mass spectral databases. The reproducibility of the analytical equipment, methodology and tissue classification algorithms has yet to be evaluated over multiple sites, which is an essential step for developing this technique for future clinical applications. In this study, we harmonized REIMS methodology using single-source reference material across four sites with identical equipment: Imperial College London (UK); Waters Research Centre (Hungary); Maastricht University (The Netherlands); and Queen’s University (Canada). We observed that method harmonization resulted in reduced spectral variability across sites. Each site then analyzed four different types of locally-sourced food-grade animal tissue. Tissue recognition models were created at each site using multivariate statistical analysis based on the different metabolic profiles observed in the m/z range of 600–1000, and these models were tested against data obtained at the other sites. Cross-validation by site resulted in 100% correct classification of two reference tissues and 69–100% correct classification for food-grade meat samples. While we were able to successfully minimize between-site variability in REIMS signals, differences in animal tissue from local sources led to significant variability in the accuracy of an individual site’s model. Our results inform future multi-site REIMS studies applied to clinical samples and emphasize the importance of carefully-annotated samples that encompass sufficient population diversity.
Anti-Diabetic and Cytotoxic Evaluation of Phlomis stewartii Plant Phytochemicals on Cigarette Smoke Inhalation and Alloxan-Induced Diabetes in Wistar Rats
Authors: Rasheed Mamoon Ur , Naqvi Syed Ali Raza , Rasool Nasir , Shah Syed Adnan Ali , Zakaria Zainul Amiruddin
Published: November 2022

The generation of free radicals in body causes oxidative stress and consequently different metabolic disorders. There are numerous environmental and emotional factors that trigger free radical generation, cigarette smoke (CS) is one of them. In addition to free radical production, it also increases the risk of developing type II diabetes, cancer, and has adverse effects on other organs such as liver and kidneys. In the present study, extracts of leaves, flower, and whole plant of P. stewartii Hf. in methanol were analyzed using LC-ESI-MS and investigated for their cytotoxic properties against HepG2 cell line and CS alloxan-induced diabetes in Wistar albino rats model. A total of 24 rats were kept in aerated cage for eight weeks and exposed to CS following the administration of single dose of alloxan@140 mg/kg body weight at the end of six weeks to induce diabetes mellitus (DM). The cytotoxic activity of extracts against HepG2 was recorded in the order; leaves methanol (LM) > flower methanol (FM) and whole plant methanol (WPM). The IC50(1/4) values were in the order of 187 (LM) > 280 (FM) > 312 (WPM) µg/mL against HepG2. In positive control group, CS- and alloxan-induced diabetes significantly increased (p < 0.05) the level of alanine alkaline phosphatase (ALP), aminotransferase (ALT), aspartate aminotransferase (AST), low density lipoprotein (LDL), bilirubin, total protein, creatinine, uric acid, blood urea, globulin, total oxidant status (TOS), and malondialdehyde (MDA), as compared to negative control group. In conclusion, according to the results of this study, P. Stewartii methanol extracts showed good antioxidant, anticancer activity and worked well to recover the tested clinical parameters in CS/alloxan-induced diabetes animals, which indicated the extracts also possess good antidiabetic, hepatoprotective, and nephroprotective potential.
Research on Intelligent Robot Point Cloud Grasping in Internet of Things
Authors: Wang Zhongyu , Li Shaobo , Bai Qiang , Song Qisong , Zhang Xingxing , Pu Ruiqiang
Published: November 2022

The development of Internet of Things (IoT) technology has enabled intelligent robots to have more sensing and decision-making capabilities, broadening the application areas of robots. Grasping operation is one of the basic tasks of intelligent robots, and vision-based robot grasping technology can enable robots to perform dexterous grasping. Compared with 2D images, 3D point clouds based on objects can generate more reasonable and stable grasping poses. In this paper, we propose a new algorithm structure based on the PointNet network to process object point cloud information. First, we use the T-Net network to align the point cloud to ensure its rotation invariance; then we use a multilayer perceptron to extract point cloud characteristics and use the symmetric function to get global features, while adding the point cloud characteristics attention mechanism to make the network more focused on the object local point cloud. Finally, a grasp quality evaluation network is proposed to evaluate the quality of the generated candidate grasp positions, and the grasp with the highest score is obtained. A grasping dataset is generated based on the YCB dataset to train the proposed network, which achieves excellent classification accuracy. The actual grasping experiments are carried out using the Baxter robot and compared with the existing methods; the proposed method achieves good grasping effect.