bluuebunny/crossref_metadata_2025 huggingface dataset:
Relatos de familiares sobre autismo a partir da teoria lacaniana dos quatro discursos
Authors: Silva Graziela Mezin da , Tilio Rafael De
Published: December 2024

Nos últimos anos, houve aumento expressivo no número de crianças e adolescentes diagnosticados como autistas. O objetivo deste estudo foi analisar os efeitos do diagnóstico de autismo nos relatos de familiares com base na teoria dos quatro discursos de Lacan. Foram entrevistadas oito mães, três pais, um irmão, uma irmã e um avô de adolescentes diagnosticados com autismo, cujos conteúdos foram organizados por tipo de membros da família (mães; pais; irmãos/avós) e analisados a partir da teoria dos quatro discursos de Lacan. As mães destacaram o apaziguamento do sofrimento e das insuficiências diante do filho (discurso da histérica) após o diagnóstico de autismo por parte de um profissional da saúde (discurso do mestre), circulação discursiva que funciona por um tempo, pois a sobrecarga de cuidados e conflitos não cessavam por completo; para os pais/homens o diagnóstico de autismo dos filhos ou foi recebido como submissão às mães e aos profissionais da saúde (discurso do mestre) ou como recusa, cuja resposta foi o reforço dos esquemas tradicionais de masculinidade; os irmãos e avô ou entravam em conflitos com os saberes das mães e médicos quanto ao diagnóstico de autismo (discurso do mestre) ou recusavam-no, prestando solidariedade e compaixão às particularidades do autista (semelhante aos efeitos do discurso do analista). Essas diferentes circulações dos discursos entre os (tipos de) membros da família destacam as dificuldades de cumprimento das exigências sociais da parentalidade, dos cuidados e do convívio que podem obscurecer as singularidades dos autistas.
Palavras-chave: Autismo. Parentalidade. Teoria dos discursos.
Reflexões sobre um caso clínico de stroke mimic conversivo sob a perspectiva da Psicanálise
Authors: Ferreira Vanessa Sajnaj , Lazzaretti Claire Terezinha
Published: December 2024

O Acidente Vascular Cerebral (AVC) é uma disfunção neurológica que pode comprometer as funções cognitivas e motoras, sendo uma das principais causas de morte no mundo. Nesse contexto, estão os simuladores de AVC, denominados stroke mimics, que são quadros de origem não vascular com comprometimentos semelhantes aos dos AVCs, entre os quais se encontram os quadros conversivos, sem etiologia orgânica. A maioria dos estudos sobre os stroke mimics parece ter como objetivo o diagnóstico diferencial e se pautar na perspectiva médica, sem aprofundamento nos aspectos subjetivos. O presente trabalho discute um caso clínico de stroke mimic conversivo a partir da perspectiva da Psicanálise. Trata-se de um estudo de caso. A amostra consiste em um paciente atendido em um hospital público de alta complexidade, durante Residência Multiprofissional em Psicologia. Pelo presente trabalho, foi possível produzir reflexões sobre o stroke mimic conversivo e a história subjetiva do paciente, com base nas teorias de Freud e Lacan.
Palavras-chave: Acidente Vascular Cerebral. Histeria. Psicanálise.
Marxismo e Psicanálise: uma articulação possível rumo à revolução brasileira
Authors: Gomes Maria C.
Published: December 2024

Marxismo, Psicanálise e revolução propõe debates urgentes, promovido por autores de peso, sobre o horizonte revolucionário brasileiro. Vemos tratar ali questões centrais à Psicanálise, entre as quais a articulação da clínica ao social, mas também temas periféricos de debates, que nem por isso são menos importantes, entre os quais a proposta de um resgate do corpo-território como potência revolucionária. Outros debates importantes, mais próximos ao campo do marxismo e ainda assim pensando a articulação com a Psicanálise como práxis, Manoel nos leva a pensar alguns dos modos sintomáticos de contrarrevolução. Por fim, o livro nos aponta a importância de modificar as imagens dadas e de imaginar novos mundos, a partir do que será proposto como oniropolítica. Propondo como ferramenta na construção desses mundos não uma saída pronta, mas uma modificação nos modos de como se fazem as perguntas, elevando o nível dessas, para que, mais adiante, possamos inventar outras ferramentas rumo à construção da revolução brasileira.
Palavras-chave: Marxismo. Psicanálise. Revolução.
A maternidade e o bebê imaginário
Authors: Monteiro Felipe de Oliveira Ketlin
Published: December 2024

O presente artigo tem por finalidade discorrer acerca do processo de concepção e luto do bebê imaginário, destacando a importância deste para a vinculação mãe-bebê. Durante a gestação, a mulher empreende um trabalho imaginativo a partir do qual ela constrói o bebê imaginário, concebendo este como uma imagem idealizada e perfeita do feto que carrega em seu ventre. O bebê imaginário é fruto das expectativas, desejos e devaneios da futura mamãe, sendo o alvo do investimento narcísico e libidinal da gestante. Após o nascimento, este bebê idealizado será confrontado com o bebê da realidade, que nunca será exatamente igual ao que foi fantasiado ao longo da gravidez. Assim, será necessário que a mãe realize um luto pela perda do bebê imaginário para, então, poder se vincular ao bebê real, assegurando um espaço para sua constituição psíquica enquanto sujeito diferenciado dela e portador de características e identidade próprias.
ESTUPRO DE VULNERÁVEL: ANÁLISE JURÍDICA E JURISPRUDENCIAL DA CONSTITUIÇÃO DE FAMÍLIA ENTRE VÍTIMA E AGRESSOR
Authors: Souza Barbara Murielli Bemvindo de , Domingos Naityllan Araújo , Vasconcelos João Lucas Bispo Lino
Published: December 2024

This paper addresses the theory of "distinguishing" and its implications for legal decisions on the crime of rape of a vulnerable person, according to article 217-A of the Brazilian Penal Code. The research examines the evolution of case law interpretations on this criminal provision, with emphasis on the application of new understandings in the Superior Courts, especially with regard to the circumstances involving the consent of the victim and the formation of a family. The general objective is to understand the new case law understandings and how they impact first instance decisions, considering the principles of the best interest of the child, reasonableness and proportionality. The methodology used was bibliographical research, based on legal doctrines, scientific articles and case law, in addition to the quantitative approach to analyze judicial decisions. The research sought to highlight the changes in the positions of the Supreme Court of Justice, particularly with regard to the application of the theory of "distinguishing", and how this theory can influence the conviction or acquittal in cases of rape of a vulnerable person, considering the family context and constitutional rights.
ANÁLISE DE FATORES DE RISCO ASSOCIADOS A LESÕES EM PRATICANTES DE CROSSFIT: UMA REVISÃO INTEGRATIVA
Authors: Justino Neto Manoel , Luna Rafael Evangelista , Oliveira Sâmia Eloi , Coelho Eduardo da Silva , Monteiro Júnior Astor de Jesus Peixoto , Oliveira Paulo Guilherme Sampaio de , Dias Breno , Passos Lidyanne Cardoso , Silva Francisco Mayron Sousa e , Silva Naiana Deodato da
Published: December 2024

CrossFit is a high-intensity physical training method that aims to develop skills in ten areas of physical fitness. The practice of this training has been associated with a higher incidence of injuries, especially among men, who tend to seek less guidance from instructors. This study aimed to evaluate the risk factors for injuries in CrossFit practitioners, through a literature review, and to explore physiotherapeutic approaches aimed at enhancing the performance of athletes and students. Data was collected between September and October 2024, using the VHL, PubMed and LILACS databases, from 2016 to 2024. There were 17 articles (3 in BVS, 12 in PubMed and 2 in LILACS), in the end, 7 articles were considered suitable for analysis. The results showed that the common risk factors for injuries in CrossFit practitioners involve muscle overload and joint problems, the results also indicated effective physiotherapeutic approaches to enhance the athletes' performance. In conclusion, the study highlighted the importance of physiotherapeutic approaches to prevent and treat injuries in CrossFit athletes. The correct technical execution of exercises, combined with targeted physiotherapeutic interventions, is essential in reducing risks and improving athletes' performance.
PREVALÊNCIA DA DOR LOMBAR E DA PERCEPÇÃO DA QUALIDADE DE VIDA EM MOTORISTAS DE TRANSPORTE PÚBLICO: UMA REVISÃO INTEGRATIVA
Authors: Gomes Georgia Maria Oliveira , Oliveira Deylane Menezes Teles de , Barreto Maryana Tallyta Silva , Rodrigues Valéria de Sousa Viralino Silva , Neves Lara Fábia Duarte , Sereno Eduarda Freitas , Santana Geísa de Morais , Silva Jéssyca Maria Oliveira da
Published: December 2024

A lombalgia é caracterizada por dor e limitação de movimento na coluna lombar, causada pelo sobrecarregamento de músculos, ligamentos e tendões. Os principais fatores incluem posturas inadequadas, movimentos repetitivos e fraqueza muscular na região lombar. Sob essa perspectiva esse estudo teve como objetivo analisar o nível da prevalência de dor lombar e percepção da qualidade de vida em motoristas de transporte público. Por meio de uma revisão integrativa da literatura, uma busca foi realizada nas bases de dados LILACS, BMC Public Health, PUBMED e Scielo, através dos descritores Lombalgia, Qualidade de vida, Transtornos Traumáticos Cumulativos, que discorreram sobre resultados da prevalência de dor lombar e da percepção de qualidade de vida referente a motoristas de transporte público e as buscas resultaram em 71 artigos, sendo que apenas 8 foram considerados elegíveis para a análise de dados. Os resultados do estudo mostraram que a dor lombar é uma condição comum entre os motoristas, afetando substancialmente sua qualidade de vida e capacidade funcional. Entre os fatores identificados, destaca-se a postura inadequada, a falta de pausas durante o expediente, o tabagismo e o sedentarismo, que juntos contribuem para o aumento da prevalência de dor lombar. Em conclusão, esses achados indicam a necessidade de um enfoque multidisciplinar para reduzir a dor lombar entre motoristas, que envolva melhorias nas condições de trabalho, bem como programas de incentivo à mudança de hábitos, como a cessação do tabagismo e a promoção da atividade física.
Case Study of Implementation of Administrative Innovation in Improving the Quality of Health Services
Authors: Nelwetis  , Antik Pujihastuti
Published: December 2024

Administrative innovation is crucial for enhancing health service quality. As health systems evolve, effective administration can expedite service delivery, minimize patient wait times, and enhance the accuracy of patient data. In today's society, there are heightened expectations for health service quality, including information accuracy and accessibility. Implementing innovative, technology-driven administrative systems can bolster public trust in healthcare institutions.This study investigates the changes before and after the implementation of such innovations, assessing their effectiveness in addressing common administrative challenges. Employing a qualitative case study methodology with a descriptive approach allows for an in-depth exploration of administrative innovation processes in specific health facilities and their impacts on service quality. Key respondents include health workers—doctors, nurses, and administrative staff—directly involved in these innovations, alongside patients who evaluate their satisfaction with the changes.Findings indicate positive responses from both health workers and patients regarding the innovations. Health workers reported increased efficiency in their tasks, while patients experienced improved service quality. Despite challenges such as the need for training and concerns over data privacy, there is optimism for continued development of these innovations to foster a more modern and efficient healthcare system. Ultimately, an integrated approach to administrative innovation aims to achieve safer, more efficient, and higher-quality health services accessible to all community members.
EFFECTIVENESS OF THE HOOK, BOOK, LOOK, AND TOOK (HBLT) TEACHING METHOD ON THE SPIRITUAL GROWTH OF EARLY CHILDHOOD STUDENTS AT PAUD RUMAH BELAJAR BABA
Authors: Priscila Yossika , Nauli Jhonnedy Kolang
Published: December 2024

This study aims to evaluate the effectiveness of the Hook, Book, Look, And Took (HBLT) method on the spiritual growth of early childhood education (PAUD) students at Rumah Belajar Baba. The research employs a qualitative approach with a case study methodology, involving in-depth observation and document analysis. Data were collected through direct observation of learning activities, interactions between educators and students, and feedback from students and parents regarding the HBLT learning process. The results indicate that the HBLT method significantly contributes to the spiritual growth of students, as evidenced by an enhanced understanding of spiritual values, emotional engagement, and daily religious practices. The discussion reveals that the integration of technology in learning provides a more interactive and personalized experience, strengthening the connection between students and spiritual content. However, challenges in implementation, such as limitations in training, mentoring, and disparities in access, need to be addressed to improve the effectiveness of this method. The study recommends broader utilization of the Hook, Book, Look, And Took HBLT with adjustments to overcome existing obstacles and enhanced training for educators to maximize the potential of this method in the context of spiritual education.
Transforming Medical Libraries: Opportunities, Challenges, and Strategies for Integrating Artificial Intelligence
Authors: Orubebe Ebiere Diana , Ijaja Esther Mamodu , Ogwula John Ahiaba , Oladokun Bolaji David
Published: December 2024

This study examines the role of Artificial Intelligence (AI) in transforming medical libraries, focusing on identifying opportunities, challenges, and strategies for effective integration. Medical libraries, essential resources for healthcare professionals, are increasingly leveraging AI to improve information retrieval, data management, and user services. The study aims to analyze the benefits AI brings to medical libraries, the obstacles to its adoption, and best practices for implementation. To achieve this, three specific objectives guided the study. A qualitative approach was applied, using a systematic review of literature from databases such as Scopus, Web of Science, and Google Scholar. Articles published between 2020 and 2024 were included, with non-English publications excluded. Findings indicate that AI offers substantial benefits, including enhanced information retrieval, automated data management, and improved user engagement through personalized services and research support. However, challenges such as ethical issues, data privacy concerns, infrastructure needs, and staff training remain. The study concludes that, while AI holds great potential for advancing medical libraries, overcoming these challenges will require strategic planning, investment in infrastructure, and the use of transparent, explainable AI solutions.
Maltrato y abandono de animales domésticos en la zona sur de la ciudad de Oruro
Authors: Dayra Yazira Ignacio Alvaro , Torrico Núñez Ronal , Lucana Lovera Lisbeth , Vallejos Márquez Jheremy , Morales Bejarano Rodrigo
Published: December 2024

El presente artículo de investigación aborda el creciente problema del maltrato y abandono de animales domésticos en la zona sur de Oruro, destacando su impacto social y ético. La introducción señala que el maltrato animal no solo refleja violencia social, sino que también constituye un problema ignorado en la legislación y aplicación de normas, como la Ley 700 en Bolivia. El planteamiento del problema resalta estadísticas alarmantes, como 87 casos de biocidio en 2023, y un 80% de perros "semidomiciliados", generando riesgos sanitarios y sociales. Los objetivos incluyen investigar las causas y efectos de este fenómeno y proponer soluciones como campañas de sensibilización y adopción responsable. La metodología emplea métodos inductivo, deductivo, exegético y documental, con observaciones directas, encuestas a 50 personas y análisis documental, permitiendo una visión integral del problema. Los resultados muestran que el 84% de los encuestados ha presenciado maltrato animal, principalmente abandono (40%) y falta de alimentación (26%). Un 98% apoya una ley de protección animal. La conclusión destaca la necesidad de aplicar normativas, aumentar la educación sobre bienestar animal y vincular esta problemática con otros problemas sociales, subrayando la urgencia de una respuesta integral para prevenir el maltrato y abandono.
Efecto de polipéptidos linforeticulares, en los valores hemáticos e inmunoglobulina G en un grupo de equinos de paso colombiano en Tabio, Cundinamarca
Authors: Pacheco González Diana Patricia , Bermúdez Rodríguez Adriana Paola , Díaz Rojas Cesar Augusto , Acero Plazas Víctor Manuel
Published: December 2024

Los Polipéptidos linforeticulares de origen hepático y esplénico porcino son una alternativa como inmunoestimulantes y coadyuvantes en diferentes procesos biológicos y patologías. 
Este suplemento de apoyo metabólico se asocia al concepto de que la célula es una fábrica de proteínas y necesita por consiguiente de un soporte metabólico. 
El objetivo general de este trabajo fue determinar el efecto de los polipéptidos linforeticulares sobre los valores hemáticos y de inmunoglobulina G en un grupo de equinos de paso criollo Colombiano en Tabio, Cundinamarca. 
Se seleccionaron 20 equinos sanos de un criadero, separados en un grupo control y un grupo experimental a los cuales se les suministró vía oral polipéptidos linforeticulares “Uprone®” a una dosis de 200 mg/equino/día. 
A cada animal se le analizaron los posibles cambios en los cuadros hemáticos y pruebas de inmunoglobulina G, en toma de muestras a los días 0, 15 y 30. Al aplicar las prueba estadística de diseño factorial A x B y Tukey para determinar si hubo diferencias entre las variables(hematíes, hematocrito, linfocitos, neutrófilos, plaquetas, globulinas, inmunoglobulina G) con respecto al tratamiento de cada grupo experimental, se determinó que en ninguno de los grupos hubo diferencias estadísticamente significativas en cuanto al efecto del suministro de Uprone®. 
Sin embargo, encontramos diferencias significativas en cuanto al tratamiento y al periodo. 
El uso de polipéptidos linforeticulares no mostró efectos secundarios en ninguno de los animales tratados. 
El tratamiento con polipéptidos linforeticulares mostró incrementos en los valores de globulina contribuyendo con el sistema inmune de los equinos tratados.
ИССЛЕДОВАНИЕ ПЕРЕХОДНЫХ ПРОЦЕССОВ ПАРАМЕТРИЧЕСКОГО ИСТОЧНИКА ТОКА
Authors: Ускенбаев Дониёр Эсанкулович , Мендыбаев Сергазы Амергалиевич , Тошмуродов Ёркин Кахрамонович
Published: December 2024

This article investigates the dynamic characteristics of a parametric current source (PCS) and its mathematical model. The electromagnetic processes described by the fundamental equations are analyzed using the PCS mathematical model. Simulations of PCS dynamic processes are performed under varying load and resonance circuit parameters. The research findings provide practical recommendations for improving the efficiency of PCS and its application in various technical devices.
DOSSIÊ SEMIÓTICA DISCURSIVA
Authors: Bueno Alexandre Marcelo , Fulaneti Oriana de Nadai
Published: December 2024

Apresentação do dossiê Semiótica discursiva: unidade e diversidade, proposto pelo GT de Semiótica da ANPOLL.
The Socio-Cultural Identities of Local Films and Reception on Global Platforms
Authors: Masood Nomana , Bilal Ahmad
Published: December 2024

Aim of the Study: The revival of the local film industry with the introduction of digital technologies in the past two decades marks a shift in the local film culture of Pakistan, and a few initiatives have been taken to create a socio-cultural impact through this medium. Local films represent the socio-cultural identities of society; however, their reception on global platforms needs to be investigated.
Methodology: This research paper analyses the storyline and depiction of socio- cultural issues in a selected Pakistani film; “Dukhtar” and debates the strengths and challenges of the content to find a path to the OTT platforms.
Findings: The subject matter of “Dukhtar” is similar to a Netflix production; “Bulbul”, and the content analysis of both films, provides some interesting findings about the cultural, economic, and social depiction.
Conclusion: The outcome of the research suggests that the combination of creative input combined with innovative ideas and updated digital technologies will foster local films on the global platforms to earn creative capital.
Beyond Regimes: The Prospects of Regionalisation in South Asia
Authors: Khan Durr e Shahwar , Bashir Hira , Khan Muhammad Fahim
Published: December 2024

Aim of Study: Over the years, all South Asian countries have experienced repeated regime changes throughout the political spectrum. However, most South Asian countries, like most developing countries, currently have a hybrid regime. Gaps in the research highlight the necessity to investigate and establish the relationship between the hybridity ratio and its influence on South Asia's regionalisation possibilities. As a result, this article explores the influence of different regime types on regionalisation in South Asia and why, despite several regimes, regionalisation has remained an elusive goal for the area.
Methodology: The methodologies used in this study are descriptive and exploratory, emphasising assessing, comparing, and analysing the data's multiple dimensions and interpretations, both hidden and apparent.
Findings and conclusion: As a result, it may be inferred that the role of regimes in defining the possibilities of South Asian regionalisation is unclear and requires additional reflection. However, there is enough evidence to assume that altering the hybridity ratio (toward democratic inclinations) may assist South Asia in the pursuit of its goal of regionalisation.
Mindfulness and Humor Styles as Predictors of Personal Growth Initiative in Undergraduate University Students of Lahore, Pakistan
Authors: Rahim Aiman
Published: December 2024

Aim of the Study: This study examined mindfulness and humor styles as correlates and predictors of personal growth initiative (PGI) in undergraduate university students of Lahore, Pakistan.
Methodology: Purposive sampling strategy was used to obtain data from 300 students (150 = men; 150 = women) between the age range of 18 and 22 years in five different public and private universities in Lahore. Demographic sheet, Trait Mindful Attention Awareness Scale (Brown & Ryan, 2003), Humor Styles Questionnaire (Martin et al., 2003), and the Personal Growth Initiative II Scale (Robitschek et al., 2012) were used to measure the variables.
Findings: The results identified a significant positive relationship of mindfulness and adaptive humor styles (self-enhancing humor and affiliative humor) with PGI in undergraduate university students. Maladaptive humor styles (self-defeating humor and aggressive humor) had a significant negative relationship with PGI in undergraduate university students. Mindfulness and humor styles significantly predicted dimensions of PGI in undergraduate university students.
Conclusion: The findings provide further evidence for mindfulness and adaptive humor styles as an important resource for PGI.
How Social Businesses are Creating Sustainable Business Models
Authors: Nadeem Syed Amad
Published: December 2024

Aim of the Study: The purpose of this study is to give a practical example of how a social business is transforming business models.
Methodology: Case study methodology is used. One major company is studied and the findings related to that company are presented
Findings: The purpose of a social business is not just to make a profit. But the larger goal of any social business is to meet the social needs of people. The case of Akhuwat has shown that it is possible to maintain a sustainable business model while at the same time serving a social purpose
Conclusion: Akhuwat came up with a new model of social business in which they distributed interest-free loans to the needy. The idea was to distribute interest-free loans to the needy when the traditional micro-finance sector was charging competitive mark-ups on micro-loans. Akhuwat came up with the model of accepting donations directly form people and distributing them directly among the needy. But, over time, it has emerged as the largest micro-finance institution of its kind, which speaks for the success of its programs. Hence, we can see how Akhuwat helped achieve the SDG of poverty alleviation by adopting a new business model.
Perspective of Mental Health Professionals toward Stigma and Discrimination Faced by the Caregivers of Patients with Bipolar Disorder: A Qualitative Study
Authors: Noor-Ul-Ain  , Liaqat Hira
Published: December 2024

Aim of the Study: The present study was conducted to explore the perspectives of mental health professionals on stigma and discrimination faced by the caregivers of patients with Bipolar Disorder.
Methodology: The qualitative research design was used in the present study to get detailed information on stigma and discrimination. Participants were selected through a purposive sampling strategy. In-depth and face-to-face semi-structured interviews were conducted with 6 mental health professionals practicing in government institutes of Lahore. The interviews typically lasted for about 20 minutes. The interviews were recorded and then transcribed. The results were analyzed using thematic analysis.
Findings: Six major themes emerged, which included; perpetrators of stigma against caregivers, forms of stigma experienced by caregivers, root causes of stigma: lack of education and superstitious beliefs, challenges faced by caregivers as a result of stigma, demographical and geographical dimensions of stigma, and proposed initiatives to overcome stigma among caregivers.
Conclusion: All the themes included different subthemes, explaining the perspectives of mental health professionals regarding stigma and discrimination.
Reliability and Validity of Urdu Version of Autism Spectrum Quotient (AQ) for Children and Adolescent
Authors: Nazir Imran , Noor Hina , Muhammad Fateh
Published: December 2024

Aim of the Study: In Pakistan, there is a dearth of contextualized tools for measuring the traits of children having Autism Spectrum Disorder (ASD). The current study was conducted to determine the validity and reliability of the Urdu version of the Autism Spectrum Quotient (UAQ) for children with ASD.
Methodology: The study was conducted in two stages. In the first stage, forward and backward Urdu translation by the researcher with the help of six bilingual (English and Urdu) experts, was carried out. Content and face validity were carried out by experts in this stage. Suggestions and recommendations given by the experts were administered for the pilot testing on 30 children. In the second stage reliability, test-retest reliability, inter-rater reliability, predictive validity and Content Validity Index (CVI) were analyzed.
Findings: Findings showed that coefficient of Alpha reliability for Urdu version of Autism Spectrum Quotient (UAQ) was 0.952, test-retest was found as 0.738, inter-rater reliability was found to as 0.828, and Scale wise Content Validity Index (S-CVI) was found as 0.93. Results showed that UAQ was proved to be appropriate, acceptable, reliable and valid tool to use in Pakistan.
Conclusion: The scale was found to be linguistically and culturally suitable for the Pakistani context. Findings of this study could be beneficial to psychologists, teachers, parents, and researchers who intend to investigate symptoms of autism for children and adults of average intelligence.
Effectiveness of Dexamethasone as an Adjuvant to Bupivacaine in Supraclavicular Brachial Plexus Block
Authors: Kumar Jha Prabin , Laxmi Shah Bindu , Kumari Thakur Shruti , Thakur Avinash
Published: December 2024

Supraclavicular Brachial Plexus block is a simple and effective technique of providing anesthesia for elbow, forearm and hand surgery. This study investigated the onset of sensory and motor blockade and duration of analgesia after addition of dexamethasone with bupivacaine in supraclavicular brachial plexus block. An observational, comparative study was performed at Bir Hospital and National Trauma Center, Kathmandu. Forty patients undergoing surgery of elbow, forearm and hand under Supraclavicular Brachial Plexus Block, with 0.25% bupivacaine with dexamethasone (n = 20) in group I versus 0.25% bupivacaine with normal saline (n = 20) in group II with equal volume of 30 ml in each group. Randomization was done with lottery system using sealed envelope. Onset of sensory and motor blockade and duration of analgesia was compared in both the groups. The rescue analgesia injection diclofenac 75 mg was given if Visual Analogue Score was five or more. Each patient was assessed postoperatively by a blinded investigator at regular intervals of 15 minutes in first hour, 30 minutes in next hour and then hourly till the time to first rescue analgesia. SPSS version 24.0 software was used. Continuous variables like onset of sensory and motor block and time to first rescue analgesia was assessed with student’s t-test and Chi square test was applied to asses categorical variable like VAS score. The time to onset of sensory block in bupivacaine only group (505.50±72.52) seconds compared to bupivacaine with dexamethasone group (249.75±78.36) seconds. Time to onset of motor block in bupivacaine only group (792.00±89.94) seconds compared to bupivacaine with dexamethasone group (506.25±94.35) seconds. Time to first rescue analgesia in bupivacaine only group (537.00±162.25) minutes compared to bupivacaine with dexamethasone group (1371.00±282.95) minutes. Time to onset of sensory and motor block was significantly faster and duration of analgesia was significantly prolonged in bupivacaine with dexamethasone group compared to bupivacaine only group in patient undergoing surgery of arm, forearm, and hand surgery under supraclavicular brachial plexus block.
Odpłatny charakter „darmowych” usług Facebooka. Teza z wyroku Regionalnego Sądu Administracyjnego Lazio (Rzym) z 10 stycznia 2020 r. w sprawie Facebook, sygn. 261/20
Authors: Kulesza Marcin
Published: December 2024

Artykuł przedstawia wątek decyzji włoskiego organu ochrony konkurencji i konsumentów (AGCM) oraz sądu administracyjnego, który badał odwołanie od tej decyzji, dotyczące uznania wartości ekonomicznej danych przekazywanych Facebookowi przez użytkowników rejestrujących się w serwisie. Sąd potwierdził konstatację AGCM w tym zakresie, zgodnie z którą dane te mają wartość ekonomiczną, z czym wiąże się wzajemność transakcji subskrypcji usług serwisu oraz, dalej, obowiązki operatora względem użytkownika traktowanego jako konsumenta. To pierwszy przypadek takiego orzeczenia organu i sądu państwa członkowskiego UE.
L’évolution du Service québécois du livre adapté et des collections adaptées au Québec en 2024
Authors: Chalifoux Ariane
Published: December 2024

Le Service québécois du livre adapté (SQLA) offre gratuitement depuis 2005 une collection de documents en braille, en DAISY audio et d’autres formats adaptés pour la population vivant avec une déficience perceptuelle. Le présent article présente un bref historique de ces services ainsi que les différents acteurs du document adapté et du document accessible.
La gestion des collections en contexte parlementaire : un aperçu du corpus documentaire de la Bibliothèque de l’Assemblée nationale
Authors: Cormier Véronique , Falardeau Marise
Published: December 2024

La Bibliothèque de l’Assemblée nationale du Québec est unique, non seulement en raison de sa mission de bibliothèque parlementaire, mais aussi par son corpus documentaire rare et diversifié qui compte à la fois livres, journaux, revues, archives et objets patrimoniaux. La gestion des collections en bibliothèque parlementaire est liée à plusieurs défis, notamment le suivi des changements technologiques, l’adaptation à l’évolution du cadre législatif, le développement de nouveaux champs d’acquisition et la mise en place des meilleures pratiques de préservation des collections.
The Culturally Informed-Social Justice School Counselor Supervision Model
Authors: Sandifer Mariama , Tuttle Malti , Mecadon-Mann Melissa , Wilson Katrina
Published: December 2024

School counselors cultivate spaces of equity and inclusion for all students however, many school counselors lack preparedness to fulfill these responsibilities. During training programs, school counseling graduate students are provided practical opportunities to develop skills to examine school policies and practices. However, site supervisors are not always adequately prepared or trained regarding the theory and practice of supervision to facilitate fieldwork experiences. Program faculty are called to provide support for site supervisors to strengthen their ability to fulfill this role. The authors discuss and outline their designed comprehensive culturally informed, social justice-oriented supervision model for school counselor site supervision and training. Practice examples and implications for counselor educators and site supervisors are provided.
UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins
Authors: Ninagawa Satoshi , Matsuo Masaki , Ying Deng , Oshita Shuichiro , Aso Shinya , Matsushita Kazutoshi , Taniguchi Mai , Fueki Akane , Yamashiro Moe , Sugasawa Kaoru , Saito Shunsuke , Imami Koshi , Kizuka Yasuhiko , Sakuma Tetsushi , Yamamoto Takashi , Yagi Hirokazu , Kato Koichi , Mori Kazutoshi
Published: December 2024

How the fate (folding versus degradation) of glycoproteins is determined in the endoplasmic reticulum (ER) is an intriguing question. Monoglucosylated glycoproteins are recognized by lectin chaperones to facilitate their folding, whereas glycoproteins exposing well-trimmed mannoses are subjected to glycoprotein ER-associated degradation (gpERAD); we have elucidated how mannoses are sequentially trimmed by EDEM family members (George et al., 2020; 2021 eLife). Although reglucosylation by UGGT was previously reported to have no effect on substrate degradation, here we directly tested this notion using cells with genetically disrupted UGGT1/2. Strikingly, the results showed that UGGT1 delayed the degradation of misfolded substrates and unstable glycoproteins including ATF6α. An experiment with a point mutant of UGGT1 indicated that the glucosylation activity of UGGT1 was required for the inhibition of early glycoprotein degradation. These and overexpression-based competition experiments suggested that the fate of glycoproteins is determined by a tug-of-war between structure formation by UGGT1 and degradation by EDEMs. We further demonstrated the physiological importance of UGGT1, since ATF6α cannot function properly without UGGT1. Thus, our work strongly suggests that UGGT1 is a central factor in ER protein quality control via the regulation of both glycoprotein folding and degradation.
Molecular, cellular, and developmental organization of the mouse vomeronasal organ at single cell resolution
Authors: Hills Max Henry , Ma Limei , Fang Ai , Chiremba Thelma , Malloy Seth , Scott Allison R , Perera Anoja G , Yu C Ron
Published: December 2024

We have generated single cell transcriptomic atlases of vomeronasal organs (VNO) from juvenile and adult mice. Combined with spatial molecular imaging, we uncover a distinct, previously unidentified class of cells that express the vomeronasal receptors (VRs) and a population of canonical olfactory sensory neurons in the VNO. High-resolution trajectory and cluster analyses reveal the lineage relationship, spatial distribution of cell types, and a putative cascade of molecular events that specify the V1r, V2r, and OR lineages from a common stem cell population. The expression of vomeronasal and olfactory receptors follow power law distributions, but there is high variability in average expression levels between individual receptor and cell types. Substantial co-expression is found between receptors across clades, from different classes, and between olfactory and VRs, with nearly half from pairs located on the same chromosome. Interestingly, the expression of V2r, but not V1r, genes is associated with various transcription factors, suggesting distinct mechanisms of receptor choice associated with the two cell types. We identify association between transcription factors, surface axon guidance molecules, and individual VRs, thereby uncovering a molecular code that guides the specification of the vomeronasal circuitry. Our study provides a wealth of data on the development and organization of the accessory olfactory system at both cellular and molecular levels to enable a deeper understanding of vomeronasal system function.
Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis
Authors: Supradit Kittiya , Prasopdee Sattrachai , Phanaksri Teva , Tangphatsornruang Sithichoke , Pholhelm Montinee , Yusuk Siraphatsorn , Butthongkomvong Kritiya , Wongprasert Kanokpan , Kulsantiwong Jutharat , Chukan Amnat , Tesana Smarn , Thitapakorn Veerachai
Published: December 2024

Background

Cholangiocarcinoma (CCA) is high in morbidity and mortality rates which may be due to asymptomatic and effective diagnostic methods not available. Therefore, an effective diagnosis is urgently needed.

Methods

Investigation of plasma circulating miRNA (cir-miRNA) was divided into two phases, including the discovery phase (pooled 10 samples each from three pools in each group) and the validation phase (17, 16, and 35 subjects of healthy control (HC), O. viverrini (OV), and CCA groups, respectively). The plasma from healthy control subjects, O. viverrini infected subjects, and CCA subjects was used. In the discovery phase, plasma was pooled by adding an equal volume of plasma, and cir-miRNA was isolated and analyzed with the nCounter® SPRINT Profiler. The significantly different cir-miRNAs were selected for the validation phase. In the validation phase, cir-miRNA was isolated and analyzed using real time-quantitative polymerase chain reaction (RT-qPCR). Subsequently, statistical analysis was conducted, and diagnostic parameters were calculated.

Results

Differential plasma cir-miRNA profile showed at least three candidates including miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers. From validation of these cir-miRNAs by RT-qPCR, the result showed that the satisfied sensitivity and specificity to differential CCA group from HC and OV group was obtained from miR-4532 (P < 0.05) while miR-423-5p and miR-93-5p can be used for differential CCA from OV and HC group (P < 0.05) with high specificity but limited the sensitivity. In conclusion, candidate cir-miRNAs have been identified as potential biomarkers including miR-423-5p, miR-93-5p and miR-4532. Screening by miR-4532 and confirmed with miR-423-5p, miR-93-5p were suggested for differential CCA patients in the endemic area of O. viverrini.
Análise da governança ambiental, social e corporativa (ESG) e sua relação com o marketing ambiental
Authors: Barbosa Emili Matos , Moraes Clauciana Schmidt Bueno de , Martires Giulia Malaguti Braghini Marcolini , Bonaretto Cinthia Mara Vital , Gualter Leonardo Prudente Torres
Published: December 2024

Diante dos crescentes impactos ambientais negativos e da urgência em atender metas estabelecidas por conferências e acordos globais, é fundamental que as empresas adotem práticas sustentáveis. Tendo em vista esse cenário, este estudo explora a evolução da gestão ambiental até o conceito de ESG (ambiental, social e governança), posicionando-o como um diferencial competitivo e potencial redutor de custos para as organizações. Ao analisar marcos temporais e a normatização ESG, bem como as particularidades do marketing ambiental, incluindo o greenwashing, destaca-se a relevância de uma abordagem estratégica e transparente na implementação dessas práticas. Este artigo avalia indicadores dos Relatórios de Sustentabilidade do Grupo Boticário, Natura&Co e Mary Kay, relativos ao ano de 2022, selecionando três indicadores, um de cada eixo ESG, de acordo com a norma ABNT PR 2030/2022. A análise revela estratégias, desafios e ações adotadas por essas empresas, permitindo a comparação das abordagens ESG. Os resultados evidenciam a aplicação dos indicadores propostos e o uso do marketing ambiental, ressaltando a importância do alinhamento entre sustentabilidade, responsabilidade social e desempenho empresarial eficaz. Assim, esta pesquisa contribui para a compreensão da integração das práticas ESG e seu reporte, destacando seu papel fundamental no contexto atual dos negócios globais.
Histomorphological Study of Thyroid Lesions in Autopsy Specimens: A Cross-sectional Study
Authors: Sekar Mithraa Devi , Jigalur Parvathi S , Nayak Gajanan H , Reddy Purushotham
Published: December 2024

Introduction: The thyroid gland has been the subject of intense research and considerable attention due to the broad spectrum of diseases, ranging from functional and immunologically mediated enlargements to neoplastic lesions. Pathology within the endocrine system is not commonly found at autopsy, and when identified, it is even less frequently the cause of death. Studying asymptomatic thyroid lesions in living individuals is complex, making an autopsy study the best approach for this purpose. The data collected during the study can provide valuable insights for future epidemiological and clinical studies.

Aim: To examine the histomorphological features and spectrum of thyroid lesions in autopsy specimens.

Materials and Methods: The present study was a descriptive cross-sectional and prospective study carried out on the 140 autopsy specimens of the entire thyroid gland, dissected from deceased individuals during post-mortem examinations conducted in the Department of Pathology, at the Karnataka Institute of Medical Sciences (KIMS), Hubballi, Karnataka, India, from 1 November 2016 to 31 October 2017. The study examined the histomorphological features and spectrum of thyroid lesions in autopsy specimens. The statistical analysis was carried out using Statistical Packages for Social Sciences (SPSS) software version 14.0.

Results: A total of 140 autopsy specimens of the whole thyroid gland were included during the study period. The age of the patients ranged from 18 to 68 years. The mean weight of the thyroid gland was 19.24 grams (minimum 10 grams and maximum 50 grams). The peak incidence of thyroid diseases was observed in the fourth to fifth decades of life. Thyroid disease was predominantly seen in females compared to males, with a male-to-female ratio of 1:4.7. In present study, 90 cases (64.3%) were normal; 49 cases (35.0%) were non neoplastic lesions; and 1 case (0.7%) was classified as a neoplastic lesion. Goitre 34 (67.4%) cases was the most common non neoplastic lesion, followed by Hashimoto’s thyroiditis 9 (18.4%) cases. Other less commonly encountered non neoplastic lesions included lymphocytic thyroiditis 4 (8.2%) cases, primary hyperplasia 1 (2%) case, Reidel’s thyroiditis 1 (2%) case, and thyroglossal cyst 1 (2%) case. Only one neoplastic lesion was observed, which was papillary microcarcinoma of the conventional type, accounting for 0.7% of the cases studied.

Conclusion: The present study provided data regarding the distribution of different types of thyroid pathologies in autopsy specimens in the North Karnataka region. Although females constituted only 42.1% of the study population, a higher proportion of females exhibited various diagnostic pathological lesions. These incidental lesions indicate the burden of thyroid lesions in that region, which could have been detected through routinely available screening tests for thyroid conditions.
A REVIEW ON UNDERSTANDING MATRASHITEEYA ADHYAYA OF ASHTANGA HRIDAYA ON MAINTAINING HEALTH
Authors: Mohanty Bishnupriya , Kadu Surabhi
Published: December 2024

Maintaining health depends not only on the amount and quality of food consumed, but also on how it is consumed. Food digestion, absorption, and assimilation are intricate processes in which physiological, psychological, social, and physical elements all come into play. In order to get full benefit from food, it's also important to abide by Ayurvedic guidelines on what, when, where, and how to eat. Aharavidhi Niyama (rules for consuming food) as mentioned in Ashtanga Hridaya Sutra Sthana Matrashitiya Adhyaya has explored and interpreted here in this study. Eating and dietary guidelines are compiled from various Ayurvedic text with central focus on Ashtanga Hridaya . In order to gather information about the dietary guidelines prescribed by Ayurveda, several Ayurvedic texts were examined, including Ashtanga Hridaya, Ashtanga Samgraha, Sushruta Samhita, Charaka Samhita, Sharangdhara Samhita, Bhavaprakasa, and Yogaratnakara. The idea has been presented with Ashtanga Hridaya at its core. Dietary restrictions and dining rules make up the two categories of rules. According to the review's conclusions, breaking these guidelines can cause a person to become engulfed in a sea of illnesses; therefore, observing them will be beneficial to one's general health.
Effect of Inorganic, Organic and Biofertilizers on Growth and Yield of Garlic (Allium sativum L.) cv. Yamuna Safed - 4 (G-323)
Authors: Kumari Ankita , Kumar Jitendra , Kumar Rajesh , Rai Mritunjay , Singh Harendra , Srivastava Kajal
Published: December 2024

A study on the research entitled “Effect of inorganic, organic and biofertilizers on growth and yield of garlic (Allium sativum L.) cv. Yamuna Safed - 4 (G-323)” was conducted to evaluate the effect of different fertilizers on growth and yield of garlic at the Horticultural Research Farm of Doon (P.G.) College of Agriculture Science and Technology, Dehradun, Uttarakhand during 2023-2024. The experiment was laid out in randomized block design. The growth and yield parameters of garlic were significantly influenced by different treatments of inorganic, organic and biofertilizers. The maximum growth in terms of plant height (72.46 cm), number of leaves per plant (6.73), length of leaves (43.80 cm), stem girth (10.89 mm), chlorophyll content of leaves (79.88 mg/g) and yield per hectare (108.00 q/ha) were observed in the treatment T3 [NPK (100%)]. This study highlights the dual importance of achieving high garlic yields with NPK while advocating for the integration of organic and biofertilizers to enhance soil health, reduce dependency on synthetic inputs, and ensure long-term agricultural sustainability.
Exploring the Relationship between Attitude and Achievement in Map Reading Skills among Higher Secondary Geography Students in Murshidabad, West Bengal, India
Authors: Ganai Barun
Published: December 2024

This study focused on the attitude and achievement towards map reading (Topographical Map) of Higher Secondary Geography students of Murshidabad District of West Bengal. Basically the study followed the descriptive survey research design. Simple random sampling was adopted for selecting two hundred (200) male and female students. In this study the population was considered all rural and urban Higher Secondary Geography students of Murshidabad District. The data was collected through questionnaire which is followed the 5point Likert scale made by investigator. For fulfilling the research objective, five hypothesis and one research question was applied. The data were analysed through MS Excel and SPSS 20.0 version software. The finding revealed that, locale of students had significant effect on their attitude and achievement towards topographical map reading but gender had no notable influence. There is a slight positive relation between two attributes towards map reading.