bluuebunny/crossref_metadata_2025 huggingface dataset:
Сорбция коричной и гидроксикоричных (кофейной и хлорогеновой) кислот, таксифолина и умбеллиферона на активном угле БАУ-А
Authors: Подолина Елена Алексеевна , Ханина Миниса Абдуллаевна , Мухин Виктор Михайлович , Лежнина Марина Георгиевна , Кузнецова Юлия Александровна , Небольсин Александр Егорович
Published: July 2020

К мономерным полифункциональным природным биологически активным вешествам (БАВ)растительного происхождения относят коричную и гидроксикоричные (кофейная, хлорогеновая) кис-лоты, кумарины (умбеллиферон) и таксифолин, которые в небольших количествах содержатся практи-чески во всех лекарственных растениях (ЛРС). Целью настоящего исследования является изучение ад-сорбционной и десорбционной способности БАВ на активном угле БАУ-А.Адсорбцию БАВ осуществляли из растворов стандартных образцов на активном угле БАУ-А сразмером частиц 2.8-2.0 мм. Адсорбцию БАВ осуществляли в стационарных условиях при ламинарномперемешивании (на смесителе Shaker 3.02) и при турбулентном перемешивании (смесителе типаVortex). Экспериментально определены времена достижения сорбционного равновесия БАВ и их сте-пени сорбции. Так при ламинарном перемешивании наиболее полное сорбирование происходит в те-чение 15-30 мин, а при турбулентном – за 3-6 мин. Полученные изотермы сорбции БАВ на БАУ-Апринадлежат к L-типу (коричная кислота и умбеллиферон) и S-типу (КфК, ХгК, ТФ) согласно класси-фикации Гиббса и подтверждают физический механизм сорбции.По изотермам адсорбции рассчитаны физико-химические параметры с использованием теориимономолекулярной адсорбции (уравнения Фрейдлинха, Ленгмюра), полимолекулярной адсорбции (мо-дель БЭТ) и теории объемного заполнения микропор (уравнение Дубинина-Радушкевича). Полученныевеличины энергии Гиббса подтверждают, что природные фенольные соединения адсорбируются в мик-ропорах за счет ван-дер-ваальсовых сил, а поверхностные функциональные группы АУ образуют во-дородные связи сорбат-сорбент.Десорбцию БАВ осуществляли в динамических условиях на колонке длиной 180 мм, диамет-ром 15 мм, высота слоя АУ 20 мм. В качестве элюирующих растворов применены полярные индиви-дуальные (метанол) и бинарные (вода – этанол (φ2=0.5), вода – ацетонитрил (φ2=0.8) растворители. Всеэлюирующие растворители в течение 30 мин элюируют БАВ на 73-83%.Таким образом, получено, что АУ БАУ-А является эффективным адсорбентом по отношениюк коричной и гидроксикоричным кислотам, умбеллиферону и таксифолину. Для элюирования БАВможно применять метанол или бинарные смеси (вода – этанол или вода – ацетонитрил) при этом изсорбента БАУ-А можно выделить практически 83% БАВ. Активный угол БАУ-А (ГОСТ 6217-74 ОАЭНПО «Неорганика» г. Электросталь, Московской области) рекомендован для выделения коричной игидроксикоричных кислот, умбеллиферона и таксифолина из водных растворов.
Использование MS Excel для обработки неразделенных пиков на хроматограммах
Authors: Дейнека Виктор Иванович , Туртыгин Александр Владимирович , Нгуен Ван Ань , Олейниц Елена Юрьевна , Дейнека Людмила Александровна
Published: July 2020

В работе на примере триацилглицеринов льняного масла и антоцианов плодов винограда сортаМолдова предложен способ компьютерного моделирования не полностью разделенных пиков с использованием программы MS Excel. Благодаря предложенному способу для неразделенных пиков возможен расчет таких параметров как число теоретических тарелок, разрешение пиков, количественное определение не полностью разделяющихся веществ. Полученные результаты сопоставляются с результатами, получаемыми стандартными для программного обеспечения хроматографов способами. Показано, что при существенном различии «полуширин» неразделенных пиков корректное соотношение между их содержанием может быть рассчитано только после их разделения гауссовыми функциями. Установлено, что дополнительное уширение возможно в том случае, если пик объединяет два изомера (например, изомеров положения триацилглицеринов) с небольшим различием удерживания между ними. Эмпирически установлено, что небольшое отклонение хроматографических пиков исследованных объектов от Гауссового распределения может быть компенсировано добавлением небольшого пика с большим временем удерживания, параметры которого могут быть подобраны при компьютерном моделировании пика в программе MS Excel.
Разделение α- и β-аланина, смесей аминокислот и дипептида полимером с молекулярным отпечатком α-аланина
Authors: Заварыкина Светлана Александровна , Королёв Александр Игоревич , Зяблов Александр Николаевич
Published: July 2020

В работе проведено разделение смесей аминокислот, а также α-аланина и глицил-глицина.Цель работы состояла в выделение α-аланина из смесей аминокислот α- и β-аланина, α- аланина и гли-цина, α-аланина и глицил-глицина полимерами с молекулярными отпечатками.Для разделения аминокислот был получен высокоселективный сорбент на основе сополимерадиангидгида 1,2,4,5-бензолтетратракарбоновой кислоты с 4,4'-диаминодифенилоксидом. В качестветемплата использовали α-аланин.Исходные растворы аминокислот с концентрацией 0.5 моль/дм3 были пропущены через па-троны, заполненные 3 г сорбента, на основе ПМО-α-аланина, со скоростью 0.2 см3/мин. Объем раство-ров составлял 25 см3. Определение аминокислот в элюате (15 см3) проводили методом жидкостнойхроматографии на приборе Agilent 1260 Infinity (Agilent Technologies, CA,US).При пропускании через патрон с ПМО-α-аланина смеси аминокислот и α-аланина с глицил-глицином в элюате было обнаружено 0.30±0.02 моль/дм3 α-аланина. Установлено, что полимеры с мо-лекулярным отпечатком α-аланина сорбируют только целевую аминокислоту – α-аланин и не способны к молекулярному распознаванию β-аланина, глицина и глицил-глицина.Предложенная методика разделение структурных изомеров аланина и смеси аминокислот наполимере с молекулярными является перспективной, т.к. существующие способы разделения изомеров аминокислот достаточно дороги и специфичны
Взаимодействие суперабсорбента «Твердая вода» модифицированного ионами цинка и марганца с водой
Authors: Зенищева Анна Витальевна , Семенов Виктор Николаевич , Кузнецов Вячеслав Алексеевич , Кущев Петр Олегович , Лукин Анатолий Николаевич
Published: July 2020

Одной из обсуждаемых проблем в сельскохозяйственной отрасли являются природно-клима-тические погодные изменения, проявляющиеся в виде глобального потепления, которые приводят красширению зон засушливых районов и изменению почв. Последствием этих процессов является воз-растание риска развития земледелия в этих зонах. Традиционно применяемые методы орошения и внесения в почву минеральных удобрений и микроэлементов не всегда доступны и эффективны. Для экономической выгоды и интенсификации рассматривается возможность применения ранее синтезированного редкосшитого полимерного материала со свойствами суперабсорбента «Твердая вода» в качестве не только резервуаров для поддержания требуемого уровня влажности, но и внесения в почву необходимых микроэлементов.В данной работе изучены гидратационные свойства образцов суперабсорбента «Твердая вода»,модифицированного солями сернокислого цинка и сернокислого марганца (II). Целью исследованийявлялось уточнение и корректировка полученных ранее результатов по гидратации образцов сорбента «Твердая вода», а также установление влияния электролитов ZnSO4 и MnSO4 в качестве микроэлементов на поглощение воды суперабсорбентом. В результате эксперимента определена способность модифицированных образцов сорбента к влагопоглощению, а также предложен способ определения установления энергетических параметров водородных связей в системе суперабсорбент – вода. Для этого использована универсальная программа обработки спектров (УПОС) по данным ИК-спектроскопии.Предложен один из возможных вариантов образования гидроксокомплексов «вода – ион металла» вфазе модифицированного микроэлементами сорбента.В ходе исследования показано, что наибольшая энергия водородных связей характерна длягидроксокомплексов с участием карбоксилатных или карбоксильных групп в матрице сорбента. Дляувеличения количества воды, поглощаемой суперабсорбентом, необходимо использовать его в катионной или анионной форме. Впервые установлено образование монодентатных и бидентатных лигандов при взаимодействии суперабсорбента с ионами сульфата цинка в растворе. Выявлено, что более стойкие ассоциаты образуются ионами Zn2+ c COOH- и аминогруппами, по сравнению с ионами Mn2+. Данные ИК-спектроскопии подтверждают, что влагопоглощение суперабсорбентом с ZnSO4 составляет 490 дм3 одним килограммом полимера, в то время как с MnSO4 всего 390 дм3/кг.
PMN- 04 Measurement of Intracellular Reactive Oxygen Species (ROS) levels in Human PMN v1
Authors: Cosentino Marco , Storelli Elisa , Luini Alessandra , LM Legnaro Massimiliano , Rasini Emanuela , Ferrari Marco , Marino Franca
Published: July 2020

List of published work using this protocol: Immune Profile of Hyaluronic Acid Hydrogel Polyethylene Glycol Crosslinked: An in Vitro Evaluation in Human Polymorphonuclear Leukocytes. Franca Marino, Marco Cosentino, Massimiliano Legnaro, Alessandra Luini, Julia Sigova, Roberto Mocchi, Trello Lotti, Nicola Zerbinati. Dermatol Ther. 2020 Apr 10; e13388. doi: 10.1111/dth.13388. Online ahead of print. A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions. Alex Mabou Tagne, Franca Marino, Massimiliano Legnaro, Alessandra Luini, Barbara Pacchetti, Marco Cosentino. Int J Mol Sci. 2019 Apr 13;20(8):1833. doi: 10.3390/ijms20081833. β 2 -Adrenoceptors Inhibit Neutrophil Extracellular Traps in Human Polymorphonuclear Leukocytes. Franca Marino, Angela Scanzano, Laura Pulze, Monica Pinoli, Emanuela Rasini, Alessandra Luini, Raffaella Bombelli, Massimiliano Legnaro, Magda de Eguileor, Marco Cosentino . J Leukoc Biol. 2018 Sep;104(3):603-614. doi: 10.1002/JLB.3A1017-398RR. Epub 2018 Apr 18. Adrenergic Modulation of Migration, CD11b and CD18 Expression, ROS and interleukin-8 Production by Human Polymorphonuclear Leukocytes. Angela Scanzano, Laura Schembri, Emanuela Rasini, Alessandra Luini, Jessica Dallatorre, Massimiliano Legnaro, Raffaella Bombelli, Terenzio Congiu, Marco Cosentino, Franca Marino. Inflamm Res. 2015 Feb;64(2):127-35. doi: 10.1007/s00011-014-0791-8. Epub 2015 Jan 6. The Essential Oil of Bergamot Stimulates Reactive Oxygen Species Production in Human Polymorphonuclear Leukocytes. Marco Cosentino, Alessandra Luini, Raffaella Bombelli, Maria T Corasaniti, Giacinto Bagetta, Franca Marino. Phytother Res. 2014 Aug;28(8):1232-9.doi: 10.1002/ptr.5121. Epub 2014 Jan 23. Immunomodulatory Properties of Achyrocline Satureioides (Lam.) D.C. Infusion: A Study on Human Leukocytes. Marco Cosentino, Raffaella Bombelli, Elena Carcano, Alessandra Luini, Franca Marino, Francesca Crema, Federico Dajas, Sergio Lecchini. . J Ethnopharmacol. 2008 Mar 28;116(3):501-7. doi: 10.1016/j.jep.2007.12.014. Epub 2008 Jan 6.
PMN- 05 Culture of Human PMN- IL-8 production v1
Authors: Cosentino Marco , Storelli Elisa , Luini Alessandra , LM Legnaro Massimiliano , Rasini Emanuela , Ferrari Marco , Marino Franca
Published: July 2020

Adrenergic Modulation of Migration, CD11b and CD18 Expression, ROS and interleukin-8 Production by Human Polymorphonuclear Leukocytes. Angela Scanzano, Laura Schembri, Emanuela Rasini, Alessandra Luini, Jessica Dallatorre, Massimiliano Legnaro, Raffaella Bombelli, Terenzio Congiu, Marco Cosentino, Franca Marino. Inflamm Res. 2015 Feb;64(2):127-35. doi: 10.1007/s00011-014-0791-8. Epub 2015 Jan 6.
PMN- 03 Culture of Human PMN - Migration v1
Authors: Cosentino Marco , Storelli Elisa , Luini Alessandra , LM Legnaro Massimiliano , Rasini Emanuela , Ferrari Marco , Marino Franca
Published: July 2020

Published work using this protocol: - A Novel Standardized Cannabis sativa L. Extract and Its Constituent Cannabidiol Inhibit Human Polymorphonuclear Leukocyte Functions. Alex Mabou Tagne, Franca Marino, Massimiliano Legnaro, Alessandra Luini, Barbara Pacchetti, Marco Cosentino. Int J Mol Sci. 2019 Apr 13;20(8):1833. doi: 10.3390/ijms20081833. - β 2 -Adrenoceptors Inhibit Neutrophil Extracellular Traps in Human Polymorphonuclear Leukocytes. Franca Marino, Angela Scanzano, Laura Pulze, Monica Pinoli, Emanuela Rasini, Alessandra Luini, Raffaella Bombelli, Massimiliano Legnaro, Magda de Eguileor, Marco Cosentino . J Leukoc Biol. 2018 Sep;104(3):603-614. doi: 10.1002/JLB.3A1017-398RR. Epub 2018 Apr 18. - Adrenergic Modulation of Migration, CD11b and CD18 Expression, ROS and interleukin-8 Production by Human Polymorphonuclear Leukocytes. Angela Scanzano, Laura Schembri, Emanuela Rasini, Alessandra Luini, Jessica Dallatorre, Massimiliano Legnaro, Raffaella Bombelli, Terenzio Congiu, Marco Cosentino, Franca Marino. Inflamm Res. 2015 Feb;64(2):127-35. doi: 10.1007/s00011-014-0791-8. Epub 2015 Jan 6.
Phenol-chloroform DNA purification v1
Authors: Suchan Tomasz
Published: July 2020

Because of the influence of salts on enzymatic reactions, Qiagen extractions can be purified before making RAD tags. First, it is necessary to perform a chloropane extraction (phenol / chloroform 50/50) by adding SDS to the aqueous phase (final conc. 0.1%), this eliminates contaminants introduced by the matrix of the column. Then, perform an ethanol precipitation followed by a wash with 70% ethanol. This is to eliminate the salt that was used to bind the nucleic acids to the column and also to remove EDTA (inhibitor!) which is 0.5 mM in the buffer AE. Eluting with water is nonsense as the pH is not optimal and thus yield is poor and the DNA is not buffered and there is always too much salt.
Práticas da Contabilidade Gerencial, Qualidade e Desempenho no Contexto de um Monopólio Natural
Authors: Correia Eliane Evangelista , Lima Afonso , Ching Hong Yuh
Published: July 2020

Objetivo: Este artigo tem como objetivo analisar a relação entre o uso de artefatos da contabilidade gerencial e porte, desempenho e qualidade dos serviços prestados por empresas brasileiras concessionárias de distribuição de energia elétrica, setor configurado como monopólio natural, marcado por um grande número de regulações e restrito a um número limitado de estratégias orientadas ao desempenho.

Método: A pesquisa envolveu 22 concessionárias de um universo de 63; utilizou-se para a análise das relações os testes não-paramétricos Qui-quadrado, Kruskal-Wallis, U de Mann-Whitney e τ de Kendall.

Resultados: Resultados evidenciam maior frequência da utilização dos artefatos tradicionais e sugerem uma relação entre a utilização dos artefatos e o porte da empresa. Porém, não se verificou uma relação entre a utilização desses artefatos e o desempenho nas organizações investigadas (diferenciando-se de outras pesquisas), nem com a qualidade dos serviços. Pode-se concluir que, nesse contexto de monopólio natural, informações obtidas por meio de artefatos não se prestam ao aperfeiçoamento das operações, apesar das iniciativas de um pequeno número de organizações.

Contribuições: Diversos estudos têm investigado a relação entre práticas da contabilidade gerencial (artefatos) e o desempenho organizacional em diferentes contextos, porém, pouco se sabe acerca dessa relação no contexto de setores altamente regulados.
Estratégias de Coping de Discentes Brasileiros de Ciências Contábeis
Authors: Lopes Iago Franca , Martins Meurer Alison , Douglas Colauto Romualdo
Published: July 2020

Objetivo: Compreender os elementos cognitivos e comportamentais no ambiente socioacadêmico mostra-se como uma agenda emergente de pesquisa na área de educação contábil. A partir desse incentivo, o artigo busca identificar a associação entre as estratégias de coping adotadas por discentes brasileiros de contabilidade.

 

Método: A amostra representa 311 discentes de contabilidade de Instituições de Ensino Superior localizadas no Sul do Brasil. Os dados, coletados por meio uma survey foram tratados a partir de correlação de Spearman.

 

Resultados: As estratégias de coping, representadas por ações comportamentais em resposta a situações de estresse, exaustão emocional e pressão, adotadas por discentes de contabilidade do Brasil mostram-se associadas e conduzem o comportamento desejáveis e indesejáveis do mesmo no ambiente socioacadêmico.

 

Contribuição: A universidade precisa integrar os processos relacionados as estratégias de coping no ambiente socioacadêmico por meio de políticas de atenção e apoio aos discentes, visto estar atrelado ao desenvolvimento acadêmico e as experiências que o discente desencadeará durante a sua permanência no ensino superior. Contribui-se com a promoção da temática junto as instituições de ensino, pois o ensino superior apresenta-se como uma verdadeira arena do jogo, na qual todos os atores possuem responsabilidades.
A Relação entre a estrutura de propriedade e o custo da dívida captada via emissão de debêntures no Brasil
Authors: Konraht Jonatan Marlon , Consoni Silvia , Fonseca Marcos Wagner da
Published: July 2020

Objetivo: Esta pesquisa teve como objetivo identificar a relação entre a estrutura de propriedade/controle das empresas e o custo da captação de dívida via emissão de debêntures.

Método: Foram examinadas as características de concentração de controle, concentração de propriedade e diferença entre controle e propriedade, em relação à taxa de juros (spread) paga pelas companhias de capital aberto na emissão de debêntures entre 2011 e 2018. Os dados foram analisados por meio de regressões lineares e quadráticas.

Resultados: Os resultados encontrados sugerem que, dentre as características de estrutura de propriedade/controle analisadas, somente a concentração de controle é relevante para os debenturistas no momento da precificação dos títulos.

Contribuições: A pesquisa contribui à literatura ao evidenciar que a relação entre concentração de controle e spread é quadrática. Assim, até certo ponto, o aumento da concentração de controle se reflete no aumento do custo da dívida; porém, quando essa concentração se torna muito elevada, os credores a interpretam como algo benéfico, reduzindo o custo da dívida. Tais resultados sugerem tanto os efeitos positivos e negativos decorrentes da concentração de controle estão presentes na captação de dívida; porém, os benefícios tendem a se manifestar apenas quando a concentração de controle se torna elevada.
EINIGE PROBLEME DER ENTWICKLUNG DER VERWALTUNGSGERICHTSBARKEIT IN DER REPUBLIK USBEKISTAN
Authors: Egamberdiev Azamat
Published: July 2020

I. EinleitungII. Allgemeine Prinzipien des Rechtsschutzes der Bürger gegen Verwaltungshandeln1. Das Wesen der gerichtlichen Verwaltungskontrolle2. Grundstrukturen des VerwaltungsrechtsschutzesIII. Theoretische Grundlagen und einige Probleme der Entwicklung der Verwaltungsgerichtsbarkeit1. Verwaltungsgerichtsbarkeit als ein wissenschaftliches Problema) Diskussion um die Schaffung einer Verwaltungsgerichtsbarkeitb) Begriffe und verfassungsrechtliche Herausforderungenc) Tragende Prinzipien eines rechtsstaatlichen Anforderungen entsprechenden Verwaltungsprozessesd) Verwaltungsgerichtsbarkeit als wichtige Einrichtung im öffentlichen Interesse2. Relevante gesellschaftliche, politische und rechtliche Bedingungen für die Akzeptanz der Verwaltungsgerichtsbarkeita) Das Wesen der Verwaltungsreform als Systementscheidungb) Rolle des Rechts in der rechtsstaatlichen Modernisierung des StaatesIV. Schlussbemerkungen
TOURISM IMPACT ON SOCIO-ECONOMIC DEVELOPMENT OF IVANO-FRANKIVSK CITY
Authors: Kovalska Lesia , Chorna Lyubov , Shchuka Galina
Published: July 2020

Aim: to analyze the basic documents that determine the strategic vision and implementation of the mission of the city of Ivano-Frankivsk, the volume of services provided, the impact of tourism on the economic development of the city through the number of subjects of tourism, tourists, the amount of payments to the city budget. Describe the main components that determine the current state of tourism development, in particular: hotel and restaurant facilities, staffing and information support.

Methodology – the study of the impact of tourism on the socio-economic development of the city of Ivano-Frankivsk is based on a combination of methods of sectoral and territorial analysis. In particular, a systematic approach was used for the study using the methods of comparison, statistical, analytical, etc. This methodology involves analyzing the volume of tourist services provided, the purpose of arrival and the number of visitors based on statistics and reports from individual institutions and businesses.

Results – the article analyzes the state of tourism enterprises, the situation on the market of services, indicators of tourist collection in the city budget, the number and geography of tours sold by tour operators and travel agents. Emphasis is placed on comparison of reports of establishments that took participants of mass events with city statistics, outlines the real situation regarding the number of participants in business tourism and sports tourism. The analysis of quantitative changes in indicators of hotel and restaurant establishments has been carried out and their dynamics has been presented in the context of the last two years. Attention is drawn to the information security of the tourist industry of the city.

Scientific novelty – for the first time, the impact of tourism on the socio-economic development of the city of Ivano-Frankivsk through the lens of tourist meetings, the development of hotel and restaurant establishments has been analyzed on the basis of sectoral and territorial analysis. The results of the study may underlie the writing of coursework, diploma papers, preparation of lecture-practical material, monitoring of the domestic tourist market.

Practical importance. Publication materials, conclusions can be used and used during the educational process, providing training for the national tourism industry, practical activity of tourist enterprises, for the promotion of the city of Ivano-Frankivsk in foreign and domestic tourist markets.
ECOLOGICAL PROSPECTS OF TOURISM DEVELOPMENT WITHIN DROHOBYCH URBOSYSTEM
Authors: Terletska Oksana , Kushnir Lesya , Perig Tatiana
Published: July 2020

Goal. To reveal peculiarities of formation of ecological prospects of tourism development within Drohobych urban system.

Method. The study used analytical, comparative-geographical, cartographic and synthetic methods.

Results. The prospect of this territory for ecological tourism in urban systems is shown - since it is characterized by the location within the satisfactory ecological state of forest landscapes, accessibility for all types of tourist groups, developed infrastructure and the presence of environmental problems, which often need immediate solution. Thus, territories such as the Drohobych Urbosystem create the prerequisites for obtaining aesthetic preferences, cognitive bases, as well as environmentally oriented knowledge in the implementation of tourist routes.
In general, “branding” of cities in the development of the tourism industry is a multifactorial phenomenon, which depends on its natural, historical and architectural attractiveness as well as on its ecological status, which acts as an ecological basis and general ecological background. (a necessary background that creates a natural environment beyond which it is impossible to consider the ecological effect of anthropogenic impact aimed at providing comfortable environmental conditions (natural conditions that affect life, health, production and non-productive activities of people) for tourists. That is, the environmental safety of an urban environment is a condition of a certain section of a city that eliminates harmful effects or its threat, its inhabitants and visitors, created by anthropogenic or natural influences, correspond to the formation of a natural and cultural environment that is consistent with sanitary, aesthetic and material needs. [7]

Scientific novelty is the development of theoretical, methodological and medical principles for the identification of tourist regions as an object of study, the identification of their specific features and patterns of functioning. Assessment of the environmental safety of the environment of tourist attractive urban areas should be a mandatory component of the city's brand, which is developed with the aim of obtaining the following results: improving the socio-economic and cultural development of the city; development of all forms of business in the city; tourism development; promotion of investment activity; participation in national and regional development programs; participation in international cooperation programs.

The practical importance lies in substantiation of the mechanisms of formation and implementation of the strategy of development
CLUSTER APPROACH IN THE SYSTEM OF INDUSTRIAL TOURISM
Authors: Kornus Anatolii , Siutkin Serhii , Kornus Olesia
Published: July 2020

The aim. The study is based on the need for a more thorough systematization and justification of the cluster approach to the development of the tourism industry in Ukraine, as well as the study of regional features of the clustering process of industrial tourism market.

Methodology. The methodological base of the study is the theory of economic clusters, as well as individual elements of the concepts of territorial production complexes and regional intersectoral complexes that were developed before it. The study used various theoretical methods and techniques of scientific geographical research, in particular analysis, synthesis, systematization and others.

Results. The essence of the cluster approach and the features of tourism clusters in the context of industrial tourism are briefly described. The analysis of world experience in improving the competitiveness of regions through the implementation of cluster policies and the targeted creation of territorial tourism clusters is carried out. The structure of production-tourist clusters, the features of establishing their boundaries are shown. We believe that the modern concept of production-tourism clusters, as sets of technologically connected and geographically concentrated enterprises, is quite capable of combining and absorbing the existing socio-geographical categories such as “territorial-recreational complexes” and “recreational-tourist complexes”. In our opinion, the formation of several industrial-tourist clusters in each of the regions of Ukraine looks justified in the current socio-economic conditions.

Scientific novelty. Based on the existing approaches to the definition of tourist clusters, the concept of a production-tourism cluster is formulated. By the latter, we understand the territorial enterprises combination of industry, agriculture, transport, services, or any other segment of the economy that have tourist attractiveness and conduct excursions to their facilities. In addition, the necessary elements of tourism infrastructure (transport, hotel and restaurant services, etc.) should be presented as part of such a cluster. A scheme for the gradual development of regional production-tourism clusters is proposed.

Practical significance. The results of the study can be used in the formation of regional strategies for socio-economic development, as well tourism development programs in the regions of Ukraine. The formation of production-tourism clusters will strengthen the promotion of domestic tourism. Host production tourism may well become a kind of platform for local development, and successful promotion of the region will positively affect its economy. Clustering can be a powerful tool to increase the level of tourism activities. The cluster approach will provide greater combination and interpenetration of various types of recreational and tourist activities. This will make recreational activities more effective, as more recreational needs will be met per unit of time.
Dynamic Tilt Correction Using Direct Rotational Motion Measurements
Authors: Bernauer Felix , Wassermann Joachim , Igel Heiner
Published: July 2020

Inertial sensors like seismometers or accelerometers are sensitive to tilt motions. In general, from pure acceleration measurements, it is not possible to separate the tilt acceleration from the translational ground acceleration. This can lead to severe misinterpretation of seismograms. Here, we present three different methods that can help solving this problem by correcting translational records for dynamic tilt induced by ground deformation with direct measurements of rotational motions: (1) a simple time-domain method, (2) a frequency-domain method proposed by Crawford and Webb (2000) using a coherence-weighted transfer function between rotation and acceleration, and (3) an adapted frequency-domain method that corrects only those parts of the spectrum with coherence between translational acceleration and rotation angle higher than 0.5. These three methods are discussed in three different experimental settings: (1) a reproducible and precisely known laboratory test using a high-precision tilt table, (2) a synthetic test with a simulated volcanic very-long-period event, and (3) a real data set recorded during the 2018 Mt. Kīlauea caldera collapse. All the three test cases show severe influence of tilt motion on the acceleration measurements. The time-domain method and the adapted frequency-domain method show very similar performance in all three test cases. Those two methods are able to remove the tilt component reliably from the acceleration record.
Die Deutschen – Feinde oder Partner? Eine Übersicht über polnische Autoren des Mittelalters
Authors: Pleszczyński Andrzej
Published: July 2020

Celem niniejszego artykułu było przyjrzenie się opiniom polskich średniowiecznych autorów tekstów historiograficznych o Niemcach i ich państwach: Cesarstwie oraz później powstałych niemieckich władztwach terytorialnych – sąsiadach Polski. Mnogość źródeł sprawiła, że mogły się tu znaleźć informacje o wybranych opiniach ilustrujących główne tendencje. Dodatkowo autor podjął próbę odnalezienia kulturowego podłoża formułowanych poglądów.
Trabajo y salud de los bogas del Río Magdalena en el siglo XIX
Authors: Correa-Moreno Yerson Alí , Arango-Soler Juan Manuel
Published: July 2020

En este artículo se analiza el trabajo, las relaciones de trabajo y la salud de los bogas del río Magdalena en el siglo XIX. Los bogas fueron trabajadores claves para la economía del país antes del establecimiento regular de la navegación a vapor por el Río Magdalena. Sin embargo, en el período decimonónico las élites nacionales y los viajeros extranjeros mediante sus relatos construyeron una imagen negativa de los bogadores. En ese sentido, el presente artículo busca rescatar la importancia que tuvieron los bogantes del Río Magdalena, el cumplimiento de sus deberes y las consecuencias en su salud del trabajo que realizaban. Para ello, se acude a fuentes como diarios de viajeros y marcos normativos.
Salud mental en la actualidad
Authors: Calvo Soto Andrea
Published: July 2020

Los trastornos mentales como la depresión, el trastorno de angustia, la ansiedad generalizada, el trastorno obsesivo compulsivo, entre otros, han existido siempre, pero las condiciones de nuestra sociedad relacionados con el mercado, la producción, el conocimiento, etc., implican para las personas unos importantes niveles de exigencia, así como otras formas de relacionarse, con los demás, con la tecnología, volviendo el entorno altamente competitivo, todas esas presiones pueden llevar al límite la salud mental. Esto se evidencia en el creciente número de personas con problemas de salud mental que reportan los entes sanitarios, incluyendo el suicidio dentro de las cifras de mortalidad.  Las consecuencias de los problemas mentales también pueden llevar a repercusiones físicas como: dolores musculoesqueléticos, trastornos gástricos, debilitamiento del sistema inmunitario, enfermedad cardíaca y otras afecciones.
A prospective comparative study between interlocking nail and locking compression plate for management of diaphyseal fractures of the humerus
Authors: Rathod Mallesh , Kanugula Sandeep Kumar , Raja Pannuri
Published: July 2020

Background: The aim of this study was to compare the outcomes between open reduction and internal fixation by locking compression plate (LCP) and closed reduction and internal fixation with anterograde interlocking nail (ILN) for the treatment of diaphyseal fractures of the humerus.

Methods: This is a prospective comparative study, with diaphyseal fractures of the humerus treated by LCP in 30 patients and with ILN in 30 patients. Patients were followed up to 18 months. The clinical and radiographic outcomes were assessed in terms of union, complications, reoperation rate and functional outcome using the American shoulder and elbow surgeons’ score (ASES) and Stewart and Hundley’s criteria.

Results: Union was achieved in 93.3% of patients in LCP group and 90% in ILN group. The mean blood loss in LCP group was 280±22.10 ml (160-400 ml) and in ILN group was 110±17.62 ml (70-150 ml) (p=0.001). The ASES score was 42.47±5.532 in LCP group and 40.93±6.330 in nailing group (p=0.320; p>0.05). Stewart Hundley criteria showed excellent and good results in 26/30 and 17/30 patients in LCP group and ILN group respectively (p=0.070; p>0.05). Complications and re-operation rate were higher in ILN group.

Conclusions: Our study concludes that LCP can be considered a better surgical option for the management of diaphyseal fractures of the humerus as it had lower incidence of complications, less re-operation rate and better union rate. However, there is no difference between the two groups in terms of union time and functional outcome.
O argumentowaniu z analogii w dyskursie prawniczym. Uwagi na tle sporu o stosowanie art. 745 Kodeksu postępowania cywilnego
Authors: Barszcz Tomasz
Published: July 2020

Celem artykułu jest ukazanie specyficznych cech prawniczego argumentowania w oparciu o analogię. Jest on realizowany w odniesieniu do zaistniałego w obrocie prawnym sporu dotyczącego stosowania art. 745 k.p.c. do rozstrzygania o kosztach postępowania zabezpieczającego w sytuacji, gdy: a. powód zainicjował postępowanie zabezpieczające w oparciu o nakaz zapłaty wydany w po- stępowaniu nakazowym; b. zabezpieczenie powództwa zostało wykonane przez komornika sądowego; c. pozwany nie wniósł skutecznie zarzutów od nakazu zapłaty.
The Principle of Salus Animarum as the Essence of the Adversarial System Under Canon Law
Authors: Greszata-Telusiewicz Marta
Published: July 2020

Zasada salus animarum jako istota kontradyktoryjności w systemie prawa kanonicznego

Zasada kontradyktoryjności jest warunkiem zaistnienia iudicium. Do powstania każdego proce- su, w tym również kanonicznego procesu o nieważność małżeństwa, potrzebne jest bowiem czyjeś twierdzenie wyrażające wolę realizacji swojego uprawnienia z jednoczesnym zaistnieniem twierdzenia przeciwnego, które również w swej treści wyraża wolę realizacji tego samego uprawnienia. W tym czasie, gdy te dwa sprzeczne ze sobą twierdzenia zaistnieją jednocześnie przed sędzią kościelnym, powstaje spór, który następnie może przekształcić się w iudicium.

Taką wolę rozumienia procesu kanonicznego jako kontradyktoryjnego, wyraża również Papież Franciszek w MIDI, przypominając dotychczasowe unormowania i reformując jedynie te procedury, które tego wymagały zgodnie z duchem czasu. Wprowadzenie tych zmian ma na celu pozbycie się z treści iudicium jedynie tego, co się zdewaluowało, przy czym trzon kontradyktoryjności pozostaje niewzruszony. Papież Franciszek pisze w MIDI: „…troska o zbawienie dusz, która – zarówno dzisiaj, tak jak w przeszłości – pozostaje najwyższym celem instytucji, ustaw i prawa, skłania Biskupa Rzymu do przedstawienia biskupom niniejszego aktu reformy”. Takie właśnie uzasadnienie staje u podstaw reformy Franciszkowej procesu kanonicznego opartego na zasadach procesowych.
Determinants of Investment In Islamic Crowdfunding
Authors: Ryandono Muhammad Nafik Hadi , Wijayanti Ida , Kusuma Kumara Adji
Published: July 2020

Investment decisions in Islamic Crowdfunding have many determinants, including: project quality, creator abilities, social network creators, reputation and entrepreneur experiences. This study examines the influence of significant and insignificant determinants of investment in Islamic Crowdfunding. It uses a random sampling technique with Structural Equation Modeling Partial Least Square (PLS) as the analysis model. The results show that social creators and entrepreneur experiences have a significant effect on investment in Islamic Crowdfunding. Contrastingly, project quality, creator ability, and reputation have insignificant influences. Entrepreneur experiences and reputation of the platform have dominant and least influence on investment in Islamic crowdfunding, respectively. Creator’s ability has a dominant-negative effect on Islamic Crowdfunding, and therefore, it requires special attention. The sharia values contained in all investment determinants are the primary consideration by investors. Therefore, increasingly inevitable sharia compliance is a necessity from time to time.
Sudden Increase of Antipsychotics and Induction of Deep Vein Thrombosis
Authors: Fariborzifar Arghavan , Elyasi Forouzan , Azizi Marzieh
Published: July 2020

Introduction: Antipsychotics (APs) can induce pathological blood clotting. Deep Vein Thrombosis (DVT) is a common type of Venous Thromboembolism (VTE) and a significant cause of morbidity and mortality worldwide. First or second generation APs have been specifically correlated with an increased risk of thromboembolism.
Case presentation: We report a case of a bipolar female patient who developed DVT following an increase in her daily dose of APs (olanzapine and chlorpromazine).
Conclusion: Physicians in other medical fields, including internal medicine and surgery, should be trained about the complication of DVT induced by APs.
Proximal Weakness and Hypokalemia in a Pregnant Woman: The First Presentation of Gitelman Syndrome
Authors: Taghi Najafi Mohammad , Mahdavi Sharif Pouya , Alamdari Azam , Naderi Neda
Published: July 2020

Gitelman syndrome is an inherited disorder of kidney function characterized by hypokalemia, hypomagnesemia, and hypocalciuria. Its first presentation during pregnancy might be a challenging diagnostic and management issue, as there is little data available in the medical literature. Here we report a 26-year-old pregnant woman who was diagnosed with Gitelman syndrome for the first time during her second trimester of pregnancy. Refractory hypokalemia in the 18th week of pregnancy was treated with eplerenone. The pregnancy outcome was favorable both for the mother and neonate.
The Association between Genes Polymorphisms of Heparan Sulfate Proteoglycan 2 (HSPG2) and Chondroitin Sulfate Proteoglycan 2 (CSPG2) and Intracranial Aneurysm Susceptibility: A Meta-Analysis
Authors: LIU Huahui , HUANG Wen
Published: July 2020

Background: We aimed to investigate whether the polymorphisms of gene heparan sulfate proteoglycan 2 (HSPG2) and chondroitin sulfate proteoglycan 2 (CSPG2) are associated with increased risk of intracranial aneurysms (IAs) susceptibility.
Methods: The Cochrane Library, Medline, PubMed, and Embase databases were carefully searched for potential researches before Mar 30, 2018. The title, abstract, and full text were assessed to determine whether the paper was suitable for inclusion. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were presented to assess the associations between CSPG2 and HSPG2 polymorphisms and IAs susceptibility.
Results: We enrolled 7 papers, 4 matched single nucleotide polymorphisms (SNPs) of CSPG2 (rs173686, rs251124) or HSPG2 (rs173686, rs251124), and a total of 8651 participations (3674 with IAs and 4977 for control). For the rs251124 polymorphism of CSPG2, the quantitative synthesis from 5 studies showed significant difference in the gene allele comparison of T vs. C (OR, 1.129; 95% CI, 1.029, 1.238; P=0.01). Similar results were found for rs3767137 of HSPG2 (A vs. G, OR, 0.842, 95% CI=0.759-0.935, P=0.001). However, for the rs173686 polymorphism of CSPG2 and rs7556412 polymorphism of HSPG2, no significant difference was found (P=0.259 and P=0.474, respectively)
Conclusion: The SNPs rs251124 of CSPG2 and rs3767137 of HSPG2 had statistically significant associations with IAs susceptibility. The minor allele T of rs251124 demonstrated a harmful effect but the minor allele A of rs3767137 demonstrated a protective role with regard to the risk of IAs. However, no such associations were found in the SNPs rs173686 of CSPG2 and rs7556412 of HSPG2.
Metabolically Healthy Obesity and Risk of Incident Chronic Kidney Disease in a Korean Cohort Study
Authors: YANG Youngran
Published: July 2020

Background: The incident of chronic kidney disease (CKD) of metabolically healthy obesity (MHO) has not been consistently determined.
Methods: This study used data of Anseong Ansan community-based cohort, a part of the Korean Genome and Epidemiology Study (KoGES) provided by the Korea Center for Disease Control and Prevention (KCDC). Surveys were received from the Anseung and Ansan residents every two years between 2001-2002 and 2015-2016 for a total of 7 surveys over all. The subjects were divided into 4 phenotypes based on the presenting obesity and metabolic syndrome; 1) metabolically healthy normal weight (MHNW), 2) metabolically healthy obesity (MHO), 3) metabolically abnormal normal weight (MANW), and 4) metabolically abnormal obesity (MAO). Data were analyzed using the Cox proportional hazards regression model.
Results: Of 8,865 subjects, 1,551 cases of 49,995 person-year (3.1%) developed incident CKD. At an adjusted hazard ratio (HR) of 1.13, the MHO group was not associated with a higher risk of incident CKD (95% confidence interval (CI): 0.92-1.41, P =0.234, using MHNW as the reference). The adjusted HRs of the MANW and MAO groups for incident CKD were significantly higher than those of the MHNW groups: 1.31 (95% CI: 1.05-1.64, P=0.017) for MANW and 1.49 (95% CI: 1.23-1.79, P<0.001) for MAO.
Conclusion: MHO is not associated with a high risk of CKD, and that MANW and MAO increase the risk of the incident CKD. Thus, it is important to consider metabolic health status rather than obesity when evaluating CKD risk.
The Reducing Hospital Costs through Horizontal Integration
Authors: Staňková Pavla , Papadaki Šárka , DVORSKÝ Ján
Published: July 2020

Background: This paper investigated the impact of hospitals´ horizontal integration in the Czech Republic on the cost behavior. The aim of the research was to examined the hospitals costs in specific environment of region hospitals at NUTS 3 level (Nomenclature of Units for Territorial Statistics) – Administrative Regions.
Methods: The survey was conducted in the period from April to August 2016 in the Czech Republic. The research was divided into two parts. The first part was based on data obtained from the Institute of Health Information and Statistics of the Czech Republic. We used Statgraphics Centurion XVII for the descriptive statistics and data visualization. Second part of the results was obtained through a survey research focused on managers of the horizontal integrated hospitals and their experiences with the cost behavior.
Results: The results from statistical survey showed that up to 80 percent of the observed region hospitals at NUTS 3 level, the cost of treatment for a patient per day has decreased after integration into an association. Based on primary survey, 73% hospital managers confirm these results and see one of the advantages that it is possible to reduce costs through integration of hospitals. The largest savings, according to hospital managers, are due to central purchasing and investments, together and they have a better negotiation position with suppliers.
Conclusion: We can confirm that horizontal integration of hospitals can lead to reduction of costs and higher efficiency, in the specific environment of region hospitals at NUTS 3 level.
Screening for the Interaction of Diabetes Mellitus and Other Factors in Tuberculosis
Authors: MU Min , WU Jing , WANG Jian-Hua , TAO Xin-Rong , HU Dong , LIU Kai , FANG Ke-Hong , XUE Song , SHANG Jie
Published: July 2020

The article's abstract is no available.
Suicide in Ghana: How Could the Community-Based Health Planning and Service (CHPS) Effectively Contribute to its Prevention?
Authors: ASSAN Abraham , AIKINS Moses , TAKIAN Amirhossein
Published: July 2020

The article's abstract is no available.
Obesity in Iran: Challenges Arising and Policy Options
Authors: EZATI ASAR Mohamad , HAGHI Mehdi
Published: July 2020

The article's abstract is no available.
Prevalence and Antimicrobial Resistance of Bacterial Uropathogens Isolated from Iranian Kidney Transplant Recipients: A Systematic Review and Meta-Analysis
Authors: SHAPOURI MOGHADDAM Abbas , ARFAATABAR Maryam , TAVAKOL AFSHARI Jalil , SHAKERIMOGHADDAM Ali , MOHAMMADZAMANI Zahra , KHALEDI Azad
Published: July 2020

Background: Urinary tract infection (UTI) is a major complication in patients who receive the kidney transplant. We aimed to evaluate the prevalence and antimicrobial resistance of bacterial uropathogens isolated from Iranian kidney transplant recipients.
Methods: We searched according to Prisma protocol for UTI infection, prevalence, occurrence and distribution of bacteria and their pattern of antibiotic resistance among Iranian patients who receive kidney transplant through online electronic databases with MeSh terms and text words in published references in both Persian and English languages during 1990-2017. Data analysis was performed using Comprehensive meta-analysis software (CMA) by Cochrane Q and I2 Random Effects Model.
Results: Eleven studies met the eligible inclusion criteria. The prevalence of UTI among kidney transplant patients varied from 11.7% to 67.5%. The combined prevalence of UTI was 32.6%. Among Gram-negative pathogens causing UTI, E. coli was the most dominant followed by Klebsiella pneumonia with prevalence 41.3% and 11.9%, respectively. Also, amongst Gram-positive bacteria, the highest prevalence belonged to Enterococcus spp. (9.8%) and coagulase-negative Staphylococci (9.4%). Also in Gram-negative pathogens, the most resistance was to ampicillin (91.2%), followed by ceftazidime (89.5%). The minimum resistance was against imipenem with prevalence 14.3%.
Conclusion: The combined prevalence of UTI was 32.6%. Gram-negative pathogens especially E. coli were the most agents of UTI in Iranian patients who receive kidney transplant. Also, in gram-negative pathogens, the most resistance was to ampicillin that it needs a new strategy for prophylaxis and treatment of UTI after the kidney transplant.
Roles of Parenting Practices on Risky Sexual Behaviour among Adolescents in Rural Cambodia
Authors: PAHN Jihyon , YANG Youngran
Published: July 2020

The article's abstract is no available.
Hypertension Surveillance in Rural Regions of Iran
Authors: PANAHI Mohammad Hossein , MAHDAVI HEZAVEH Ali Reza , SAMAVAT Tahereh , HODJATZADEH Alieh , YOUSEFI Elham
Published: July 2020

The article's abstract is no available.
Factors Associated with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis
Authors: SEPANDI Mojtaba , TAGHDIR Maryam , ALIMOHAMADI Yousef , AFRASHTEH Sima , HOSAMIRUDSARI Hadiseh
Published: July 2020

Background: The current study aimed to identify effective factors on the death among COVID-19 patients.
Methods: All articles published in the period Jan 1, 2020, to Mar 23, 2020, written in English and reporting factors associated with COVID-19 mortality were reviewed. The random-effects model with 95% CI was used to calculate the pooled Odds Ratio (OR) and Hazard Ratio (HR). Data were analyzed using Stata ver.11.0.
Results: The older age OR: 1.21(1.10-1.33) and male gender OR: 1.41(1.04-1.89) were most prone to death due to COVID-19. The Comorbidity with some chronic diseases such as Diabetes type2 OR: 2.42(1.06-5.52), Hypertension OR: 2.54(1.21-5.32), Kidney disorder OR: 2.61(1.22-5.60), Respiratory disorder 3.09 (1.39-6.88) and Heart diseases OR: 4.37 (1.13-16.90) can increase the risk of COVID19 mortality.
Conclusion: Infection with COVID-19 is associated with substantial mortality mainly in older patients with comorbidities. We found the significant effect of age, gender and comorbidities such as Diabetes Mellitus, Hypertension, Kidney disorders and Heart diseases on the risk of death in patients with COVID-19. The factors associated with mortality found in this research can help to recognize patients with COVID-19 who are at higher risk of a poor prognosis. Monitoring these factors can serve to give early warning for the appropriate interventions.