bluuebunny/crossref_metadata_2025 huggingface dataset:
Political Science: Seeing Like a Subversive Social Scientist
Authors: Weiss Meredith L.
Published: May 2021

Much of the work of political science revolves around institutions—the structures through which politics happens. Leaders enter the frame, of course, but often as institutions in human form: presidents, premiers, populists, and mobilizers who serve to channel and direct who does what and what they do, much like an agency or law. We might trace this pseudo-structural, largely mechanical reading of human agency to political scientists of an earlier era: the behavioralists of the 1950s and 1960s. James C. Scott began his career as just such a scholar. For his dissertation-turned-book, Political Ideology in Malaysia: Reality and the Beliefs of an Elite, Scott surveyed a gaggle of Malaysian bureaucrats to examine, effectively, the extent to which their values and assumptions supported or subverted the new democracy they served. Although itself fairly prosaic, that work foreshadows the political grime and games that soon pulled Scott in more promising directions theoretically, whether scrutinizing Southeast Asia or global patterns: disentangling structure from norms, finding agency around the margins of class and state, and rethinking how power looks and functions.
Bene Pareza: A new talmudic lexeme
Authors: Gvaryahu Amit
Published: May 2021

The Persian lexemepahrēz-,pahrēxtan(inf.), “to avoid, to abstain” and also “to care, to protect”, is found in Jewish, Christian, and Mandaic magical literature. It is also current in Mandaic works, and is found in some Geonic works in Jewish Babylonian Aramaic. It has not yet been found in the Babylonian Talmud itself. In this article I discuss a recently discovered occurrence of this word in a reconstructed codex of chapters of Babylonian Talmud, found in the Cairo Genizah (GM). I begin with a reading of the talmudicsugiya. I then discuss other uses ofpahrēzin Jewish Babylonian Aramaic, in other dialects of Eastern Aramaic, and in Middle Persian. I end with a re-reading of the talmudicsugiyain GM in light of the meaning ofpahrēz.
Investigation of a novel 2R1T parallel mechanism and construction of its variants
Authors: Liu Jingfang , Fan Xiangmeng , Ding Huafeng
Published: May 2021

A 3-RRPRR variable spherical symmetrical parallel mechanism (PM) with arc-shaped sliding pairs and no parasitic motion is presented, exhibiting two rotational and one translational (2R1T) degrees of freedom. Three limbs are symmetrically distributed between the base and end-effector; upper and lower parts of each limb are mirror symmetrical around the middle. The geometry, mobility, forward/inverse kinematics, workspace, and parasitic motion of the mechanism are analyzed, showing its ability to achieve large rotations around a continuous rotation axis. Finally, a structure synthesis strategy for variable spherical symmetrical PM is proposed, and several limb types meeting the conditions are obtained.
Analysing constraints to improve conservation decision-making: a theoretical framework and its application to the Northern Vosges, France
Authors: Mangos Anaï , Rouchier Juliette , Meinard Yves
Published: May 2021

Key to bridging knowing–doing gaps is analysis of the constraints binding interactions between decision-makers and conservation biologists to clarify the problems they address. We apply this analysis to decision situations in the Northern Vosges (France), which illustrate three kinds of constraints: governance, framework and initiative. We explore how conservation biologists can mitigate constraints so as to foster more ambitious conservation actions in each case. The first case explores attempts at reintroducing the lynx (Lynx lynx). In this case, we show that governance plays a key role, in the sense that conservation actions should focus on improving the acceptability of reintroductions to key stakeholders. The second case refers to water monitoring schemes. Here we show that framing is the dominant constraint. This means that conservation actions are tightly limited by the use of a restrictive scientific apparatus. The last case study, fish stock protection, is constrained by initiative. Here, decision-makers have too much leverage to implement solutions they favour, even if they are not the best options in conservation terms. Exploring how our framework relates to the existing literature allows us to highlight its usefulness for rationalizing conservation problem framing and for strengthening the ambitions of conservation actions.
Impact of the 2020 crises on the arts and culture in the United States: The effect of COVID-19 and the Black Lives Matter movement in historical context
Authors: Katz Stanley N. , Reisman Leah
Published: May 2021

This article discusses the impact of the COVID-19 pandemic and the Black Lives Matter movement on the arts and cultural sector in the United States, placing the 2020 crises in the context of the United States’s historically decentralized approach to supporting the arts and culture. After providing an overview of the United States’s private, locally focused history of arts funding, we use this historical lens to analyze the combined effects of the pandemic and Black Lives Matter movement on a single metropolitan area – Philadelphia, Pennsylvania. We trace a timeline of key events in the national and local pandemic response and the reaction of the arts community to the Black Lives Matter movement, arguing that the nature of these intersecting responses, and their fallout for the arts and cultural sector, stem directly from weaknesses in the United States’s historical approach to administering the arts. We suggest that, in the context of widespread organizational vulnerability caused by the pandemic, the United States’s decentralized approach to funding culture also undermines cultural organizations’ abilities to respond to issues of public relevance and demonstrate their civic value, threatening these organizations’ legitimacy.
The dark side of cultural heritage protection
Authors: Rosén Frederik
Published: May 2021

This article introduces the concept of the dark side of cultural heritage protection. It points out how the many and mostly honorable efforts to protect cultural heritage against the harms of war and conflict sometimes contribute to make cultural heritage vulnerable or even to cause its destruction. The more we talk about cultural heritage and its value and the importance of protecting it, the more interesting it becomes for some groups to target it. This article argues that states, international organizations, and the heritage community need to recognize these negative side effects and make sure to consider them in future action.
Lects in Helsinki Finnish - a probabilistic component modeling approach
Authors: Kuparinen Olli , Peltonen Jaakko , Mustanoja Liisa , Leino Unni , Santaharju Jenni
Published: May 2021

This article examines Finnish lects spoken in Helsinki from the 1970s to the 2010s with a probabilistic model called Latent Dirichlet Allocation. The model searches for underlying components based on the linguistic features used in the interviews. Several coherent lects were discovered as components in the data, which counters the results of previous studies that report only weak covariation between features that are assumed to be present in the same lect. The speakers, however, are not categorical in their linguistic behavior and tend to use more than one lect in their speech. This implies that the lects should not be considered in parallel with seemingly uniform linguistic systems such as languages, but as partial systems that constitute a network.
‘Opera and …’: The Pleasures and Perils of Amalgamation
Authors: Parker Roger
Published: May 2021

We might start with the Index, often a good indicator of a book's flavour, its local habitation. First up is ‘Abbate, acoustics, acting, Adler, Adorno’, a reassuring miscellany; later on, the German-speaking collective of ‘Schopenhauer, Schreker, Schubart, Schumann-Heink’ awakens memories of time past. ‘Ventilation systems, Verdi, vitalism’, however, turns on the landing lights for a distinctly new approach, while ‘hygiene [both mental and moral], hyperacusis, hyperaesthesia acoustica, hypnosis, hysteria’ ushers in another region entirely: medicine, pathologies. Starting at the end, we are thus prepared: a sense of anticipation is allied to hopes of intriguing surprises in the offing. And such expectations are on the whole justified. In spite of its title – that fence-sitting conjunction – this collection is a worthy and serious attempt to write new chapters in musicology's revolving challenge to the internalist preoccupations of its past.
Smartphone-Based Neuropsychological Assessment in Parkinson’s Disease: Feasibility, Validity, and Contextually Driven Variability in Cognition
Authors: Weizenbaum Emma L. , Fulford Daniel , Torous John , Pinsky Emma , Kolachalama Vijaya B. , Cronin-Golomb Alice
Published: May 2021

Objectives:

The prevalence of neurodegenerative disorders demands methods of accessible assessment that reliably captures cognition in daily life contexts. We investigated the feasibility of smartphone cognitive assessment in people with Parkinson’s disease (PD), who may have cognitive impairment in addition to motor-related problems that limit attending in-person clinics. We examined how daily-life factors predicted smartphone cognitive performance and examined the convergent validity of smartphone assessment with traditional neuropsychological tests.

Methods:

Twenty-seven nondemented individuals with mild–moderate PD attended one in-lab session and responded to smartphone notifications over 10 days. The smartphone app queried participants 5x/day about their location, mood, alertness, exercise, and medication state and administered mobile games of working memory and executive function.

Results:

Response rate to prompts was high, demonstrating feasibility of the approach. Between-subject reliability was high on both cognitive games. Within-subject variability was higher for working memory than executive function. Strong convergent validity was seen between traditional tests and smartphone working memory but not executive function, reflecting the latter’s ceiling effects. Participants performed better on mobile working memory tasks when at home and after recent exercise. Less self-reported daytime sleepiness and lower PD symptom burden predicted a stronger association between later time of day and higher smartphone test performance.

Conclusions:

These findings support feasibility and validity of repeat smartphone assessments of cognition and provide preliminary evidence of the effects of context on cognitive variability in PD. Further development of this accessible assessment method could increase sensitivity and specificity regarding daily cognitive dysfunction for PD and other clinical populations.
The official and personal seals of Tipu Sultan of Mysore
Authors: SIMS-WILLIAMS URSULA
Published: May 2021

This article looks at all the known seals of Tipu Sultan of Mysore (r. 1782-1799) particularly those found in the manuscripts which formed his Library collection, disbanded in 1799 after the fall of Seringapatam and subsequently divided between the East India Company London (now in the British Library), and the Asiatic Society of Bengal, Kolkata. By focussing on the British Library collections certain patterns of usage have come to light, possibly indicating Tipu Sultan's linguistic and literary preferences.

It gives me great pleasure to dedicate this article to Barbara Brend as a mark of appreciation for her patience and help, whose knowledge and advice has been of such benefit to a non-art historian. At the end of this article I highlight an important manuscript from the Royal Asiatic Society's collection which thanks to her sponsorship has now been digitised and is available on the web as part of the RAS digital collections.
Nutritional risk in early childhood and parent-reported school concerns
Authors: Omand Jessica A , Janus Magdalena , Maguire Jonathon L , Parkin Patricia C , Randall Simpson Janis , Keown-Stoneman Charles DG , Aglipay Mary , Birken Catherine S
Published: May 2021

Objective:

To determine if nutritional risk in early childhood is associated with parent-reported school concerns.

Design:

A prospective cohort study conducted through the TARGet Kids! primary care research network (2011–2018). Nutritional risk was measured between 18 months and 5 years of age using validated parent-completed NutriSTEP®questionnaires with eating behaviour and dietary intake subscores (0 = lowest and 68 = highest total nutritional risk score). Parent-reported school concerns were measured at school age (4–10 years of age) and included: speech and language; learning; attention; behaviour; social relationships; physical coordination; fine motor coordination and self-help skills and independence. The primary outcome was any parent-reported school concerns, and individual school concerns were used as secondary outcomes. Multiple logistic regression models were conducted adjusting for clinically relevant confounders to assess the relationship between nutritional risk and school concerns.

Setting:

Toronto, Canada.

Participants:

Children aged 18 months to 10 years.

Results:

The study included 3655 children, 52 % were male, mean NutriSTEP®score was 14·4 (sd6·4). Each 1sdincrease in NutriSTEP®total score was associated with a 1·18 times increased odds of school concerns (adj OR: 1·18, 95 % CI 1·07, 1·28,P= 0·0004), and high nutritional risk was associated with a 1·42 times increased odds of school concerns (adj OR: 1·42, 95 % CI 1·13, 1·78,P= 0·002).

Conclusions:

Nutritional risk in early childhood was associated with school concerns. Nutritional interventions in early childhood may reveal opportunities to enhance school outcomes.
Is it advantageous to use deep inspiration breath hold (DIBH) over free breathing for FAST-Forward dose fractionation scheme in treating carcinoma of left-sided breast? A dosimetric study
Authors: Nagaraj Jagadheeskumar , Chandrasekaran Anu Radha
Published: May 2021

Aim:

To study the effect of deep inspiration breath hold (DIBH) on Fast-Forward trial for left-sided breast radiotherapy dosimetrically using tangential field-in-field (FiF), flattening filtered volumetric-modulated arc therapy (FF-VMAT) and flattening filter free volumetric-modulated arc therapy (FFF-VMAT) in comparison with free breathing (FB).

Methods:

Computed tomography images were acquired on 15 patients with carcinoma of left breast in FB and DIBH. Planning target volume (PTV) and organs at risk were contoured on both image sets. Dose of 26 Gy in five daily fractions was prescribed to PTV. FiF, FF-VMAT and FFF-VMAT plans were created in treatment planning system on both FB and DIBH. PTV V95%, V107%, D0·1 cc, CI and HI, heart V1·5 Gy, V7 Gy, lung left V8 Gy, monitor units (MU) and beam ON time were used for evaluation. Different technique analysis in same breathing condition and FB versus DIBH for same planning technique were performed.

Results:

Mean of all 15 patients was reported as mean ± 1 standard deviation. PTV V95% was 97·55 ± 0·10 (FiF), 95·75 ± 0·66 (FF-VMAT) and 96·15 ± 0·46 (FFF-VMAT) in FB while 97·34 ± 0·50 (FiF), 96·03 ± 0·71 (FF-VMAT) and 95·86 ± 0·63 (FFF-VMAT) in DIBH. Heart V7 Gy was 8·53 ± 4·26 (FiF), 8·86 ± 2·20 (FF-VMAT) and 9·27 ± 2·46 (FFF-VMAT) in FB while 6·30 ± 2·98 (FiF), 5·23 ± 2·20 (FF-VMAT) and 4·68 ± 2·01 (FFF-VMAT) in DIBH. p-value of heart V7 Gy between FB and DIBH was 0·278 (FiF), 0·009 (FF-VMAT) and 0·003 (FFF-VMAT). Beam ON time for FFF-VMAT was reduced by 65% (FF-VMAT) and 11% (FiF).

Conclusion:

Conformal dose to PTV was achieved better with VMAT plans. FFF-VMAT was delivered in less time compared to FF-VMAT and FiF for 26 Gy in five fractions. Heart dose can be significantly minimised with DIBH for VMAT plans.
Multi-output Gaussian processes for multi-population longevity modelling
Authors: Huynh Nhan , Ludkovski Mike
Published: May 2021

We investigate joint modelling of longevity trends using the spatial statistical framework of Gaussian process (GP) regression. Our analysis is motivated by the Human Mortality Database (HMD) that provides unified raw mortality tables for nearly 40 countries. Yet few stochastic models exist for handling more than two populations at a time. To bridge this gap, we leverage a spatial covariance framework from machine learning that treats populations as distinct levels of a factor covariate, explicitly capturing the cross-population dependence. The proposed multi-output GP models straightforwardly scale up to a dozen populations and moreover intrinsically generate coherent joint longevity scenarios. In our numerous case studies, we investigate predictive gains from aggregating mortality experience across nations and genders, including by borrowing the most recently available “foreign” data. We show that in our approach, information fusion leads to more precise (and statistically more credible) forecasts. We implement our models in R, as well as a Bayesian version in Stan that provides further uncertainty quantification regarding the estimated mortality covariance structure. All examples utilise public HMD datasets.
The treatment gap for mental disorders in adults enrolled in HIV treatment programmes in South Africa: a cohort study using linked electronic health records
Authors: Ruffieux Y. , Efthimiou O. , Van den Heuvel L. L. , Joska J. A. , Cornell M. , Seedat S. , Mouton J. P. , Prozesky H. , Lund C. , Maxwell N. , Tlali M. , Orrell C. , Davies M.-A. , Maartens G. , Haas A. D.
Published: May 2021

Aims

Mental disorders are common in people living with HIV (PLWH) but often remain untreated. This study aimed to explore the treatment gap for mental disorders in adults followed-up in antiretroviral therapy (ART) programmes in South Africa and disparities between ART programmes regarding the provision of mental health services.

Methods

We conducted a cohort study using ART programme data and linked pharmacy and hospitalisation data to examine the 12-month prevalence of treatment for mental disorders and factors associated with the rate of treatment for mental disorders among adults, aged 15–49 years, followed-up from 1 January 2012 to 31 December 2017 at one private care, one public tertiary care and two pubic primary care ART programmes in South Africa. We calculated the treatment gap for mental disorders as the discrepancy between the 12-month prevalence of mental disorders in PLWH (aged 15–49 years) in South Africa (estimated based on data from the Global Burden of Disease study) and the 12-month prevalence of treatment for mental disorders in ART programmes. We calculated adjusted rate ratios (aRRs) for factors associated with the treatment rate of mental disorders using Poisson regression.

Results

In total, 182 285 ART patients were followed-up over 405 153 person-years. In 2017, the estimated treatment gap for mental disorders was 40.5% (95% confidence interval [CI] 19.5–52.9) for patients followed-up in private care, 96.5% (95% CI 95.0–97.5) for patients followed-up in public primary care and 65.0% (95% CI 36.5–85.1) for patients followed-up in public tertiary care ART programmes. Rates of treatment with antidepressants, anxiolytics and antipsychotics were 17 (aRR 0.06, 95% CI 0.06–0.07), 50 (aRR 0.02, 95% CI 0.01–0.03) and 2.6 (aRR 0.39, 95% CI 0.35–0.43) times lower in public primary care programmes than in the private sector programmes.

Conclusions

There is a large treatment gap for mental disorders in PLWH in South Africa and substantial disparities in access to mental health services between patients receiving ART in the public vs the private sector. In the public sector and especially in public primary care, PLWH with common mental disorders remain mostly untreated.
Identifying Key Drivers of Wildfires in the Contiguous US Using Machine Learning and Game Theory Interpretation
Authors: Wang Sally S.‐C. , Qian Yun , Leung L. Ruby , Zhang Yang
Published: May 2021

Understanding the complex interrelationships between wildfire and its environmental and anthropogenic controls is crucial for wildfire modeling and management. Although machine learning (ML) models have yielded significant improvements in wildfire predictions, their limited interpretability has been an obstacle for their use in advancing understanding of wildfires. This study builds an ML model incorporating predictors of local meteorology, land‐surface characteristics, and socioeconomic variables to predict monthly burned area at grid cells of 0.25° × 0.25° resolution over the contiguous United States. Besides these predictors, we construct and include predictors representing the large‐scale circulation patterns conducive to wildfires, which largely improves the temporal correlations in several regions by 14%–44%. The Shapley additive explanation is introduced to quantify the contributions of the predictors to burned area. Results show a key role of longitude and latitude in delineating fire regimes with different temporal patterns of burned area. The model captures the physical relationship between burned area and vapor pressure deficit, relative humidity (RH), and energy release component (ERC), in agreement with the prior findings. Aggregating the contribution of predictor variables of all the grids by region, analyses show that ERC is the major contributor accounting for 14%–27% to large burned areas in the western US. In contrast, there is no leading factor contributing to large burned areas in the eastern US, although large‐scale circulation patterns featuring less active upper‐level ridge‐trough and low RH two months earlier in winter contribute relatively more to large burned areas in spring in the southeastern US.
Afterslip and Spontaneous Aseismic Slip on the Anza Segment of the San Jacinto Fault Zone, Southern California
Authors: Shaddox Heather R. , Schwartz Susan Y. , Bartlow Noel M.
Published: May 2021

Understanding the interplay of seismic and aseismic slip is key in seismic hazard evaluation. It is particularly important to know if the same or nearby fault segments can host different slip modes and understand the transition between modes of slip. We investigate this in the trifurcation area of the Anza segment of the San Jacinto fault where deep creep driving seismicity below the geodetic locking depth has been proposed. We focus on periods following local moderate‐sized earthquakes by combining the occurrence of highly correlated families of earthquakes (i.e., closely spaced or partially overlapping events) that we describe here as near‐repeating earthquakes, seismicity, and borehole strainmeter data. We find that all Mw > 4.5 earthquakes between 2010 and 2020 triggered afterslip with coplanar families of near‐repeating earthquakes and off‐fault microseismicity. These observations include newly detected afterslip following the June 10, 2016 Mw 5.2 and April 4, 2020 Mw 4.9 local earthquakes. Afterslip geometries defined by the near‐repeating earthquake families are consistent with strain change observations. We conclude that families of near‐repeating earthquakes, similar to low‐frequency earthquakes within tremor, can be useful indicators of aseismic slip transients and can reveal faulting complexities during aseismic slip. Further, we identify the first evidence of spontaneous aseismic slip in the Anza region from near‐repeating earthquake families on two minor faults in 2015. Taken together, our observations support a model where deep microseismicity is located in a transitional region at the bottom of the seismogenic zone with spatially heterogeneous frictional properties that produce frequent aseismic slip transients near Anza.
Evaluation of Higher‐Order Quadrature Schemes in Improving Computational Efficiency for Orientation‐Averaged Single‐Scattering Properties of Nonspherical Ice Particles
Authors: Fenni Ines , Kuo Kwo‐Sen , Haynes Mark S. , Haddad Ziad S. , Roussel Hélène
Published: May 2021

We evaluate several high‐order quadrature schemes for accuracy and efficacy in obtaining orientation‐averaged single‐scattering properties (SSPs). We use the highly efficient MIDAS to perform electromagnetic scattering calculations to evaluate the gain in efficiency from these schemes. MIDAS is shown to be superior to DDSCAT, a popular discrete dipole approximation (DDA) method. This study is motivated by the fact that quality physical precipitation retrievals rely on using accurate orientation‐averaged SSPs derived from realistic hydrometeors as input to radiative transfer models (RTM). The DDA has been a popular choice for single‐scattering calculations, due to its versatility with respect to target geometry. However, being iterative‐solver‐based (ISB), the most used DDA codes, for example, DDSCAT and ADDA (formerly, Amsterdam DDA), must solve the scattering problem for each orientation of the target separately. As the size parameter and geometric anisotropy of the hydrometeor increase, the number of orientations needed to obtain accurate orientation‐averages can increase drastically and so does the computation cost incurred by the ISB‐DDA methods. MIDAS is a Direct‐Solver‐Based (DSB) code, its decomposition of the original large matrix with a high rank into multiple more manageable smaller matrices of lower ranks makes it much more computationally efficient while maintaining excellent accuracy. In addition, direct solvers consider all requested orientations at once, giving MIDAS further advantage over popular ISB‐DDA methods. MIDAS, when combined with high‐order quadrature for orientation averaging, can be greater than three orders of magnitude more efficient in obtaining RTM‐ready SSPs of complex‐shaped hydrometeors than existing ISB‐DDA methods, with the native quadrature schemes they offer.
Evaluation of 12‐Years Chinese Regional Reanalysis (1998–2009): Comparison of Dynamical Downscaling Methods With/Without Local Data
Authors: Lu Yutong , Fang Juan , Pan Yinong , Wang Shuyu , Zhou Peifeng , Yang Yi , Shao Min , Tang Jianping
Published: May 2021

High‐resolution regional reanalysis is one of the most powerful tool to study local and regional high‐impact weather events, climate extremes and climate change impact. In this study, two high‐resolution Chinese Regional Reanalysis (CNRR) datasets with a resolution of 18 km over 1998–2009, which are produced using the Gridpoint Statistical Interpolation (GSI) data assimilation system and spectral nudging (SN) technique, were assessed. The reliability of the surface and upper air variables of the CNRR datasets was evaluated by comparing with in situ observations and the European Centre for Medium‐Range Forecasts (ECMWF) ERA‐Interim (ERAIN) and ERA5 global reanalysis dataset. The evaluation of climatological and seasonal spatial distribution of near‐surface variables shows that the CNRR can provide more accurate near‐surface variables than the driving ERAIN global reanalysis, and CNRR‐GSI shows advantages against ERA5 in representing near‐surface atmosphere during cold season especially for daily maximum temperature. However, care should be taken when using the CNRR precipitation dataset, especially for heavy rainfall cases. CNRR datasets are also able to generate high‐quality upper atmospheric products especially in CNRR‐GSI experiment, which assimilates long time series of local observations. CNRR‐GSI can better represent the lower‐level horizontal wind and temperature than ERA5. By using the three‐dimensional variational data assimilation (3D‐Var) method, CNRR‐GSI outperforms the CNRR‐SN and the driving global reanalyzes. With the increase of the computing resources, the potential opportunities for improving CNRR can be expected by applying more advanced methods.
Pore‐Scale Modeling of Spontaneous Imbibition in Porous Media Using the Lattice Boltzmann Method
Authors: Liu Haihu , Sun Shilin , Wu Rui , Wei Bei , Hou Jian
Published: May 2021

A new color‐gradient lattice Boltzmann model is developed to simulate spontaneous imbibition in a porous media micromodel, which needs only two‐dimensional computational cost but considers essential three‐dimensional effects. A modified periodic boundary condition is introduced to deal with inlet and outlet boundaries with great ease and effectiveness. This model is first validated against analytical solutions and micromodel experiment. It is then used to study the spontaneous imbibition process in a homogeneous micromodel for varying viscosity ratios and contact angles. Depending on the viscosity ratio (λ) of wetting to nonwetting fluids, three different imbibition patterns are observed, namely unstable displacement (UD), stable displacement (SD), and crossover from UD to SD, which occur at , , and , respectively. When the crossover occurs, the wetting fluid saturation at breakthrough increases between two plateaus corresponding to UD and SD, respectively. Consistent with theoretical predictions from a single capillary, the wetting fluid saturation versus time follows the relation of for , and for . Due to the increased capillary valve resistance, increasing wetting phase contact angle is found to promote the flow instability, resulting in the development of preferential flow paths and thus some nonwetting fluid trapped in the flow direction. In addition, it is theoretically and numerically demonstrated that the effect of contact angle cannot be properly described by the theoretical equations derived from a single capillary because of the presence of capillary valve effect, which can be suppressed by decreasing contact angle or micromodel depth.
Effects of Tibetan Plateau Growth, Paratethys Sea Retreat and Global Cooling on the East Asian Climate by the Early Miocene
Authors: Zhang Ran , Jiang Dabang , Zhang Zhongshi , Zhang Chunxia
Published: May 2021

Paleobotanical and sedimentological records indicate that marked climatic and environmental transitions had taken place in East China by the early Miocene. These transitions were driven by paleogeographic and global climatic shifts, but the respective roles of these shifts in the Asian climate remain unclear. Here, we use the low‐resolution Norwegian Earth System Model and Community Atmosphere Model version 4 to compare the effects of Tibetan Plateau (TP) growth, Paratethys Sea retreat and global cooling on the East Asian climate change that occurred by the early Miocene. The modeling results indicate that these three factors had clearly different climatic effects in East China. In particular, TP growth increased annual precipitation in East China, while Paratethys Sea retreat and global cooling generally decreased annual precipitation in East China. In addition, the three factors studied all drove aridification in inland Asia. Considering the increased precipitation, arid/semiarid‐to‐humid shift in vegetation and high plant diversity present in East China by the early Miocene, as shown in geological records, TP growth thus played a major role in these respects.
Atmospheric Blocking Drives Recent Albedo Change Across the Western Greenland Ice Sheet Percolation Zone
Authors: Lewis Gabriel , Osterberg Erich , Hawley Robert , Marshall Hans Peter , Meehan Tate , Graeter Karina , McCarthy Forrest , Overly Thomas , Thundercloud Zayta , Ferris David , Koffman Bess G. , Dibb Jack
Published: May 2021

Greenland Ice Sheet (GrIS) albedo has decreased over recent decades, contributing to enhanced surface melt and mass loss. However, it remains unclear whether GrIS darkening is due to snow grain size increases, higher concentrations of light‐absorbing impurities (LAIs), or a combination. Here, we assess albedo controls in the western GrIS percolation zone using in situ albedo, LAI, and grain size measurements. We find a significant correlation between albedo and snow grain size (p < 0.01), but not with LAIs. Modeling corroborates that LAI concentrations are too low to significantly reduce albedo, but larger grain sizes could reduce albedo by at least ∼3%. Strong atmospheric blocking increases grain sizes and reduces albedo through increased surface temperature, fewer storms, and higher incoming shortwave radiation. These findings clarify the mechanisms by which anomalously strong blocking contributed to recent GrIS albedo decline and mass loss, highlighting the importance of improving projections of future blocking.
Preconceptional smoking alters spermatozoal miRNAs of murine fathers and affects offspring’s body weight
Authors: Hammer Barbara , Kadalayil Latha , Boateng Eistine , Buschmann Dominik , Rezwan Faisal I. , Wolff Martin , Reuter Sebastian , Bartel Sabine , Knudsen Toril Mørkve , Svanes Cecilie , Holloway John W. , Krauss-Etschmann Susanne
Published: May 2021

Background

Active smoking has been reported among 7% of teenagers worldwide, with ages ranging from 13 to 15 years. An epidemiological study suggested that preconceptional paternal smoking is associated with adolescent obesity in boys. We developed a murine adolescent smoking model before conception to investigate the paternal molecular causes of changes in offspring’s phenotype.

Method

Male and female C57BL/6J mice were exposed to increasing doses of mainstream cigarette smoke (CS) from onset of puberty for 6 weeks and mated with room air (RA) controls.

Results

Thirteen miRNAs were upregulated and 32 downregulated in the spermatozoa of CS-exposed fathers, while there were no significant differences in the count and morphological integrity of spermatozoa, as well as the proliferation of spermatogonia between CS- and RA-exposed fathers. Offspring from preconceptional CS-exposed mothers had lower body weights (p = 0.007). Moreover, data from offspring from CS-exposed fathers suggested a potential increase in body weight (p = 0.062).

Conclusion

We showed that preconceptional paternal CS exposure regulates spermatozoal miRNAs, and possibly influences the body weight of F1 progeny in early life. The regulated miRNAs may modulate transmittable epigenetic changes to offspring, thus influence the development of respiratory- and metabolic-related diseases such as obesity, a mechanism that warrants further studies for elaborate explanations.
Serum IGF1 and linear growth in children with congenital leptin deficiency before and after leptin substitution
Authors: Beghini Marianna , Brandt Stephanie , Körber Ingrid , Kohlsdorf Katja , Vollbach Heike , Lennerz Belinda , Denzer Christian , Shalitin Shlomit , Santini Ferruccio , Blum Werner F. , von Schnurbein Julia , Wabitsch Martin
Published: May 2021

Background

Evidence from in vitro and rodent studies suggests that leptin, a key signal of long-term energy reserves, promotes IGF1 synthesis and linear growth. This effect of leptin has not been fully investigated in humans. The aim of our study was to investigate the effect of leptin substitution on growth factors and linear growth in children with congenital leptin deficiency (CLD).

Methods

In this cohort study we included eight pediatric patients (six males), age 0.9–14.8 years, who were diagnosed with CLD and received leptin substitution at our University Medical Center. We calculated standard deviation scores (SDS) for serum levels of IGF1 and IGFBP3, IGF1/IGFBP3 molar ratio, and height at baseline (T0) and 12 months (T12) after the initiation of substitution with metreleptin.

Results

All patients had severe obesity (BMI-SDS mean ± SD: 4.14 ± 1.51) at T0 and significant BMI-SDS reduction to 2.47 ± 1.05 at T12. At T0, all patients were taller than the mid-parental median, yet had low IGF1 and IGF1/IGFBP3 molar ratios (IGF1-SDS$$\overline x$$

x

¯

T0: −1.58 ± 0.92, IGF1/IGFBP3 molar ratio-SDS$$\overline x$$

x

¯

T0: −1.58 ± 0.88). At T12, IGF1-SDS increased significantly (∆T0–12: 1.63 ± 1.40, p = 0.01), and IGFBP3-SDS and IGF1/IGFBP3 molar ratio-SDS showed a trend toward an increase. In the three children within the childhood growth period (post-infancy, pre-puberty) height-SDS increased (∆height-SDST0–12: 0.57 ± 0.06, p = 0.003) despite substantial weight loss.

Conclusions

These results in CLD patients are contrary to observations in children with idiopathic obesity who typically have above-mean IGF1 levels that decrease with weight loss, and therefore suggest that leptin increases IGF1 levels and promotes linear growth.
Sexual dimorphism in adipose tissue mitochondrial function and metabolic flexibility in obesity
Authors: MacCannell Amanda D. V. , Futers T. Simon , Whitehead Anna , Moran Amy , Witte Klaus K. , Roberts Lee D.
Published: May 2021

Objective

The prevalence of obesity is growing globally. Adiposity increases the risk for metabolic syndrome, type 2 diabetes and cardiovascular disease. Adipose tissue distribution influences systemic metabolism and impacts metabolic disease risk. The link between sexual dimorphisms of adiposity and metabolism is poorly defined. We hypothesise that depot-specific adipose tissue mitochondrial function contributes to the sexual dimorphism of metabolic flexibility in obesity.

Methods

Male and female mice fed high fat diet (HFD) or standard diet (STD) from 8–18 weeks of age underwent whole animal calorimetry and high-resolution mitochondrial respirometry analysis on adipose tissue depots. To determine translatability we used RT-qPCR to examine key brown adipocyte-associated gene expression: peroxisome proliferator-activated receptor co-activator 1α, Uncoupling protein 1 and cell death inducing DFFA like effector a in brown adipose tissue (BAT) and subcutaneous adipose tissue (sWAT) of 18-week-old mice and sWAT from human volunteers.

Results

Male mice exhibited greater weight gain compared to female mice when challenged with HFD. Relative to increased body mass, the adipose to body weight ratio for BAT and sWAT depots was increased in HFD-fed males compared to female HFD-fed mice. Oxygen consumption, energy expenditure, respiratory exchange ratio and food consumption did not differ between males and females fed HFD. BAT mitochondria from obese females showed increased Complex I & II respiration and maximal respiration compared to lean females whereas obese males did not exhibit adaptive mitochondrial BAT respiration. Sexual dimorphism in BAT-associated gene expression in sWAT was also associated with Body Mass Index in humans.

Conclusions

We show that sexual dimorphism of weight gain is reflected in mitochondrial respiration analysis. Female mice have increased metabolic flexibility to adapt to changes in energy intake by regulating energy expenditure through increased complex II and maximal mitochondrial respiration within BAT when HFD challenged and increased proton leak in sWAT mitochondria.
Environmental exposures associated with elevated risk for autism spectrum disorder may augment the burden of deleterious de novo mutations among probands
Authors: Pugsley Kealan , Scherer Stephen W. , Bellgrove Mark A. , Hawi Ziarih
Published: May 2021

Although the full aetiology of autism spectrum disorder (ASD) is unknown, familial and twin studies demonstrate high heritability of 60–90%, indicating a predominant role of genetics in the development of the disorder. The genetic architecture of ASD consists of a complex array of rare and common variants of all classes of genetic variation usually acting additively to augment individual risk. The relative contribution of heredity in ASD persists despite selective pressures against the classic autistic phenotype; a phenomenon thought to be explained, in part, by the incidence of spontaneous (or de novo) mutations. Notably, environmental exposures attributed as salient risk factors for ASD may play a causal role in the emergence of deleterious de novo variations, with several ASD-associated agents having significant mutagenic potential. To explore this hypothesis, this review article assesses published epidemiological data with evidence derived from assays of mutagenicity, both in vivo and in vitro, to determine the likely role such agents may play in augmenting the genetic liability in ASD. Broadly, these exposures were observed to elicit genomic alterations through one or a combination of: (1) direct interaction with genetic material; (2) impaired DNA repair; or (3) oxidative DNA damage. However, the direct contribution of these factors to the ASD phenotype cannot be determined without further analysis. The development of comprehensive prospective birth cohorts in combination with genome sequencing is essential to forming a causal, mechanistic account of de novo mutations in ASD that links exposure, genotypic alterations, and phenotypic consequences.
Endocannabinoid system mediates the association between gut-microbial diversity and anhedonia/amotivation in a general population cohort
Authors: Minichino Amedeo , Jackson Matthew A. , Francesconi Marta , Steves Claire J. , Menni Cristina , Burnet Philip W. J. , Lennox Belinda R.
Published: May 2021

Anhedonia and amotivation are debilitating symptoms and represent unmet therapeutic needs in a range of clinical conditions. The gut-microbiome-endocannabinoid axis might represent a potential modifiable target for interventions. Based on results obtained from animal models, we tested the hypothesis that the endocannabinoid system mediates the association between gut-microbiome diversity and anhedonia/amotivation in a general population cohort. We used longitudinal data collected from 786 volunteer twins recruited as part the TwinsUK register. Our hypothesis was tested with a multilevel mediation model using family structure as random intercept. The model was set using alpha diversity (within-individual gut-microbial diversity) as predictor, serum and faecal levels of the endocannabinoid palmitoylethanolamide (PEA) as mediator, and anhedonia/amotivation as outcome. PEA is considered the endogenous equivalent of cannabidiol, with increased serum levels believed to have anti-depressive effects, while increased stool PEA levels, reflecting increased excretion, are believed to have opposite, detrimental, effects on mental health. We therefore expected that either reduced serum PEA or increased stool PEA would mediate the association between microbial diversity and anhedonia amotivation. Analyses were adjusted for obesity, diet, antidepressant use, sociodemographic and technical covariates. Data were imputed using multiple imputation by chained equations. Mean age was 65.2 ± 7.6; 93% of the sample were females. We found a direct, significant, association between alpha diversity and anhedonia/amotivation (β = −0.37; 95%CI: −0.71 to −0.03; P = 0.03). Faecal, but not serum, levels of the endocannabinoid palmitoylethanolamide (PEA) mediated this association: the indirect effect was significant (β = −0.13; 95%CI: −0.24 to −0.01; P = 0.03), as was the total effect (β = −0.38; 95%CI: −0.72 to −0.04; P = 0.03), whereas the direct effect of alpha diversity on anhedonia/amotivation was attenuated fully (β = −0.25; 95%CI: −0.60 to 0.09; P = 0.16). Our results suggest that gut-microbial diversity might contribute to anhedonia/amotivation via the endocannabinoid system. These findings shed light on the biological underpinnings of anhedonia/amotivation and suggest the gut microbiota-endocannabinoid axis as a promising therapeutic target in an area of unmet clinical need.
Protein kinase CK2: a potential therapeutic target for diverse human diseases
Authors: Borgo Christian , D’Amore Claudio , Sarno Stefania , Salvi Mauro , Ruzzene Maria
Published: May 2021

CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of substrates, controls several signaling pathways, and is implicated in a plethora of human diseases. Its best documented role is in cancer, where it regulates practically all malignant hallmarks. Other well-known functions of CK2 are in human infections; in particular, several viruses exploit host cell CK2 for their life cycle. Very recently, also SARS-CoV-2, the virus responsible for the COVID-19 pandemic, has been found to enhance CK2 activity and to induce the phosphorylation of several CK2 substrates (either viral and host proteins). CK2 is also considered an emerging target for neurological diseases, inflammation and autoimmune disorders, diverse ophthalmic pathologies, diabetes, and obesity. In addition, CK2 activity has been associated with cardiovascular diseases, as cardiac ischemia–reperfusion injury, atherosclerosis, and cardiac hypertrophy. The hypothesis of considering CK2 inhibition for cystic fibrosis therapies has been also entertained for many years. Moreover, psychiatric disorders and syndromes due to CK2 mutations have been recently identified. On these bases, CK2 is emerging as an increasingly attractive target in various fields of human medicine, with the advantage that several very specific and effective inhibitors are already available. Here, we review the literature on CK2 implication in different human pathologies and evaluate its potential as a pharmacological target in the light of the most recent findings.
Understanding the psychiatric symptoms of COVID-19: a meta-analysis of studies assessing psychiatric symptoms in Chinese patients with and survivors of COVID-19 and SARS by using the Symptom Checklist-90-Revised
Authors: Xie Qin , Liu Xiao-Bo , Xu Yan-Min , Zhong Bao-Liang
Published: May 2021

Understanding the psychiatric symptoms of COVID-19 could facilitate the clinical management of COVID-19 patients. However, the profile of psychiatric symptoms among COVID-19 patients has been understudied. We performed a meta-analysis of studies assessing psychiatric symptoms of COVID-19 and SARS patients and survivors by using the Symptom Checklist-90-Revised (SCL-90-R), an instrument covering a wide spectrum of psychiatric symptoms. Studies reporting SCL-90-R subscale scores among patients with and survivors of COVID-19 and SARS were retrieved from major English and Chinese literature databases. Patients’ pooled SCL-90-R subscale scores were compared to the Chinese normative SCL-90-R data, and Cohen’s d values were calculated to indicate the severity of psychiatric symptoms. The Joanna Briggs Institute Critical Appraisal Checklist for Studies Reporting Prevalence Data was used to assess the quality of the included studies. The search yielded 25 Chinese studies with 1675 acute COVID-19 and 964 acute SARS patients, 30 COVID-19 and 552 SARS survivors during very early recovery (up to 1 month since discharge), 291 SARS survivors during early recovery (1–6 months after discharge), and 48 SARS survivors during late recovery (12 months after discharge). None of the included studies were rated as good quality. The ten SCL-90-R-defined psychiatric symptoms, which were of medium-to-severe severity (d = 0.68–3.01), were all exhibited in acute COVID-19 patients, and the severity of these symptoms decreased to mild-to-medium during very early recovery (d = 0.17–0.73). SARS patients presented eight psychiatric symptoms with mild-to-severe severity during the acute stage (d =0.43–1.88), and thereafter, the severity of symptoms decreased over the follow-up period. However, somatization (d = 0.30) and anxiety (d = 0.28) remained at mild levels during late recovery. A wide variety of severe psychiatric symptoms have been reported by acute COVID-19 patients, and these symptoms, despite decreasing in severity, persist in very early recovery. The changing trajectory observed with SARS suggests that psychiatric symptoms of COVID-19 may persist for a long time after discharge, and therefore, periodic monitoring of psychiatric symptoms, psychosocial support, and psychiatric treatment (when necessary) may be necessary for COVID-19 patients from the acute to convalescent stages.