bluuebunny/crossref_metadata_2025 huggingface dataset:
A Reversible NIR‐II Ratiometric Fluorescent Probe for Real‐Time In Vivo ATP Detection
Authors: Liu Yunyi , Zhang Lu , Chen Ying , Sun Haitao , Chen Jiajian , El‐Toni Ahmed Mohamed , Khan Aslam , Lei Zuhai , Zhang Fan
Published: July 2023

ATP plays a prominent role in shaping the evolution of immune cell responses to injury, infection, and cancer. However, real‐time monitoring of ATP levels in vivo remains a challenge, due to the lack of reliable tools that work reversibly in deep tissues. Herein, based on the Förster resonance energy transfer (FRET) strategy, a reversible ratiometric second near‐infrared window (NIR‐II) molecular fluorescent probe (CX‐RATP) is designed and synthesized. CX‐RATP exhibits a significant fluorescence ratio change with the existence of 0–10 mM ATP in vitro, which is within the range of physiological and pathological ATP concentrations. Meanwhile, the recognition process can be reversed by apyrase. It can capture the increase and decrease in ATP levels in real time before and after the treatment of acute inflammation. Besides, CX‐RATP is also successfully applied to the hepatocellular carcinoma (HCC) model and achieves in situ imaging of tumor lesions. These results all provide solid proof that CX‐RATP is a powerful tool for in vivo real‐time ATP detection.
Large covariance estimation using a factor model with common and group‐specific factors
Authors: Yafeng Shi , Chunrong Ai , Shi Yanlong , Tingting Ying , Qunfang Xu
Published: July 2023

This paper proposes a new approach to estimate large covariance matrices using multilevel factor models. In order to further improve the efficiency of the principal orthogonal complement thresholding estimator (PEOT) and the proposed estimators, the generalized least squares (GLS) method is employed to refine the estimation of the factors. A novel approach to identify number of the factors is proposed for facilitating our estimation procedure. We prove the consistency of the covariance matrix estimators and the estimators for number of the factors. Our Monte Carlo simulations show that the proposed estimators have superior properties in finite samples for all different designs, and the efficiency can be improved significantly by using GLS. Finally, we apply our estimators to a dataset consisting of weekly returns of three major stock indexes constituents, and the results suggest that the proposed methods can improve the out‐of‐sample performances of portfolio optimization.
Effects of sinapic acid on lead acetate‐induced oxidative stress, apoptosis and inflammation in testicular tissue
Authors: Tuncer Sibel Çiğdem , Akarsu Serkan Ali , Küçükler Sefa , Gür Cihan , Kandemir Fatih Mehmet
Published: July 2023

In this study, the effect of lead acetate (PbAc) and sinapic acid (SNP) administration on oxidative stress, apoptosis, inflammation, sperm quality and histopathology in testicular tissue of rats was tried to be determined. PbAc was administered at a dose of 30 mg/kg/bw for 7 days to induce testicular toxicity in rats. Oral doses of 5 and 10 mg/kg/bw SNP were administered to rats for 7 days after PbAc administration. According to our findings, while PbAc administration increased MDA content in rats, it decreased GPx, SOD, CAT activity and GSH content. NF‐kB, IL‐1β, TNF‐α, and COX‐2, which are among the inflammation parameters that increased due to PbAc, decreased with the administration of SNP. Nrf2, HO‐1, and NQO1 mRNA transcript levels decreased with PbAc, but SNP treatments increased these mRNA levels in a dose‐dependent manner. RAGE and NLRP3 gene expression were upregulated in PbAc treated rats. MAPK14, MAPK15, and JNK relative mRNA levels decreased with SNP treatment in PbAc treated rats. While the levels of apoptosis markers Bax, Caspase‐3, and Apaf‐1 increased in rats treated with PbAc, the level of Bcl‐2 decreased, but SNP inhibited this apoptosis markers. PbAc caused histopathological deterioration in testis tissue and negatively affected spermatogenesis. When the sperm quality was examined, the decrease in sperm motility and spermatozoon density caused by PbAc, and the increase in the ratio of dead and abnormal spermatozoa were inhibited by SNP. As a result, while PbAc increased apoptosis and inflammation by inducing oxidative stress in testicles, SNP treatment inhibited these changes and increased sperm quality.
Diaryl-hemiindigos as visible light, pH, and heat responsive four-state switches and application in photochromic transparent polymers
Authors: Sacherer Maximilian , Hampel Frank , Dube Henry
Published: July 2023

Photoswitches are indispensable tools for responsive chemical nanosystems and are used today in almost all areas of the natural sciences. Hemiindigo (HI) derivatives have recently been introduced as potent photoswitches, but their full applicability has been hampered by the limited possibilities of their functionalization and structural modification. Here we report on a short and easy to diversify synthesis yielding diaryl-HIs bearing one additional aromatic residue at the central double bond. The resulting chromophores offer an advantageous property profile combining red-light responsiveness, high thermal bistability, strong isomer accumulations in both switching directions, strong photochromism, tunable acid responsiveness, and acid gating. With this progress, a broader structural realm becomes accessible for HI photoswitches, which can now be synthetically tailored for advanced future applications, e.g., in research on molecular machines and switches, in studies of photoisomerization mechanisms, or in the generation of smart and addressable materials. To showcase the potential of these distinct light-responsive molecular tools, we demonstrate four-state switching, chemical fueling, and reversible inscription into transparent polymers using green and red light as well as acid/base stimuli, in addition to a comprehensive photochemical study of all compounds.
Research on fast-charging battery thermal management system based on refrigerant direct cooling
Authors: Dai Naichang , Long Jiangqi
Published: July 2023

Aiming at the problem of high battery heat generation during the super fast-charging process of electric vehicle fast-charging power batteries, this study designs a fast-charging battery thermal management system based on the refrigerant direct cooling architecture. In order to use the refrigerant of refrigerant to cool the battery quickly. Firstly, the study constructs the heat generation model of the power battery, the calculation model of the battery thermal management system, and builds the experimental device. Secondly, theoretical simulations and experimental studies were conducted for low-temperature fast-charging and high-temperature fast-charging operating conditions. The experimental results show that the designed battery thermal management system has good cooling effect and temperature uniformity.
Research with children, weeds, and a book
Authors: Deszcz-Tryhubczak Justyna
Published: July 2023

In this chapter, Justyna Deszcz-Tryhubczak looks back at an encounter with weeds, a seemingly unimportant moment in a child-led research project that has nevertheless continued to arrest her attention long after the completion of her collaboration with the children. She uses the concept of after childhood (Kraftl 2020) and the notions of attentiveness and curiosity developed in multispecies studies (van Dooren, 2018; van Dooren et al. 2016; van Dooren & Rose, 2016) to speculate retrospectively about possible movements of the research focus away from the child participants and the book they studied with her towards the plants and their lifeworld. Reflecting on the common world that might have emerged in the project as a result of these shifts, she argues for the thematic, methodological, and ethical importance of human and more-than-human entanglements in children’s literature and culture studies in the Anthropocene.
Terminology
Authors: Cabré Castellví M. Teresa , Arnau Mariona , Llopart Elisabet , Porras Jorge Mario
Published: July 2023

This volume brings together a selection of M. Teresa Cabré’s articles on terminology published after 1999 in journals of diverse nature and scope, many of which are difficult to access; articles in languages other than English are here provided in English translation. As a whole, these articles aim to represent the author’s groundbreaking work on terminology, both from a theoretical as from a methodological and applied point of view. Part I includes texts on three fundamental aspects of terminology as a field of knowledge: Firstly, general articles on the rethinking of proposals made by other authors and on the bases for the formulation of the Communicative Theory of Terminology (CTT). Secondly, articles that deal with the rethinking of the framework of this subject, with emphasis on specialised languages and communication. And thirdly, on the object of study: the terminological unit. Part II includes articles on methodology, international standards, and teaching terminology, and texts that deal with the intersection of terminology with other fields: Documentation, Translation, Neology, and Language Policy.
Health Problems
Authors: Barnes Elizabeth
Published: July 2023

Health is weird. Health is weird in a way that resists simple explanations or elegant theorizing. This book is a philosophical explanation of that weirdness and an argument that grappling with the distinctive weirdness of health can give us insight into how we might approach difficult questions about social reality. After examining extant theories of health—and finding them lacking—the book explores some particularly intractable puzzles about the nature of health, places where we often feel pulled in multiple directions or have reason to say conflicting things. On the basis of these puzzles, the book then defends a stance called ameliorative skepticism. Although health is real, there is, on this view, no way of giving a coherent, explanatorily adequate answer to the question “what is health?”. Yet adopting this skeptical stance can, it is argued, help us to better understand the role that health plays in our lives and the work that we need a theory of health to do.
The Science of Dignity
Authors: Hitlin Steven , Andersson Matthew A.
Published: July 2023

This book provides original evidence arguing for dignity as an indicator of public health by offering a scientific framework for measuring dignity and its social determinants. Like happiness or love, dignity is valued by individuals but difficult to define. Across centuries of philosophical thought and decades of social science research, dignity involves how individuals and societies relate in a way that preserves and nurtures both, a veritable bedrock of democracy. The book shows that dignity can be efficiently measured by using simple survey items that ask individuals whether there is “dignity” in their life or in how they are treated by others. It finds that unhappiness, sadness, anger, and lower general health are far more common for those reporting undignified lives. “Dignity threat” affected 21.5% of Americans in 2021, representing more than a 50% increase from 2017. Across America, differences in dignity come from inequalities in social and economic resources and from experiences of disrespect, threat, and life stress—and from mastery, mattering, and meaning. Social groups with less power generally report lower levels of dignity linked to these multifaceted resource and stress inequalities. Individuals disadvantaged by race, gender, age, or disability suffer from greater indignity, and a four-year college education delineates profound resource divides in America. Polarization itself, in terms of perceived threat from other social groups, is linked to indignity. Even amid diverse moralities, however, dignity demonstrates wide value in America. By foregrounding life’s sanctity, dignity provides a scientific basis for collective consensus and social inspiration.
Will prohibiting the use of physical punishment reduce child abuse deaths among New Zealand children?
Authors: Trevathan Sophie , Briggs Lynne
Published: July 2023

The Amendment Act (Crimes (Substituted Section 59) Amendment Act, 2007) came into force on 22 June 2007. The changes in the Act amended the right of parents to use force by way of correction toward a child. The purpose of this amendment was to provide children with a safer and more secure environment to live in that is free from violence. Such a move also has the potential to provide a clearer mandate for social workers in regard to issues of child safety. While planned, reviews to determine how effective the amendment has been have not yet been undertaken.This paper presents some key findings from a larger study exploring the issue of child abuse deaths in New Zealand. In doing so a comparison of legislation and policy between New Zealand and Sweden is presented. Sweden was used as the main focus for this comparison as it introduced a ban on use of corporal punishment of children in 1979.
From dissent to authoritarianism: What role for social work in confronting the climate crisis?
Authors: Whelan Joe
Published: July 2023

INTRODUCTION: As the environmental crisis deepens and the effects begin to emerge in the form of disruptive and destructive climate events, more nation-states have ostensibly committed to carbon net zero by 2050. Achieving this target will require a major reconstitution of economies, societies and, thus, the lived realties of peoples. This reconstitution or shift will need to occur most forcibly and rapidly in the developed economies of the global north whom, since about 1850, have been responsible for approximately 92% of surplus global emissions. Social policies, therefore, will need to be reworked and reimagined so that, in practice, they are aligned with “planetary boundaries”. Recent geopolitical summits, such as COP 26, have, arguably, resulted in lacklustre and vague commitments rather than any serious attempts at creating agreement on how to reconstitute the economies of the global north. Moreover, a model of economy predicated on continuous, and exponential growth and thus the continued metabolization of the natural environment, still appears immovable despite the threat it poses.
APPROACH, ANALYSIS AND DISCUSSION: It is against the backdrop of the global context described above that two questions are posed. The first is concerned with creating a focus for social work and asks: “What sustainable social policies should social work align with?”. The answer to this is presented as a means of progressing the task of social work in the context of climate justice. The second question builds on the answer to the first and asks, “Does arriving at an adequate response require dissent?”
The formulation of anti-vaccination mandate views in social work
Authors: Beddoe Liz
Published: July 2023

INTRODUCTION: A feature of the Covid-19 pandemic in Aotearoa New Zealand was the introduction of mass vaccination and vaccine mandates as public health measures to minimise serious illness and deaths. These measures were generally popular, with wide support, and 90% uptake of vaccines across the eligible population. A minority, however, objected strenuously to both mass vaccination and mandates. In a stressful period, this opposition and the unrest generated significant conflict. Social work was not immune to this conflict.
Approach: This commentary explores the nature of dissent in social work about vaccines in Aotearoa New Zealand after August 2021, drawing on theoretical explanations of vaccine hesitancy and refusal. Social theory is helpful in unpacking arguments for and against public health initiatives.
Conclusions: Opposition to vaccine mandates has been framed as legitimate dissent where freedom and rights are largely conceptualised within a lens of neoliberal individualism. Social work values heavily weigh in on the side of a collectivist public health approach and this does not negate human rights.
How good a physicist was the architect of the A-bomb?
Authors: Cho Adrian
Published: July 2023

Oppenheimer “was no Einstein,” says historian David C. Cassidy, but he did Nobel-level work on black holes
Supplemental Material: Chronology and erosion rate of the Pinedale glaciation, Colorado Front Range (USA), inferred from the sedimentary record of glacial Lake Devlin
Authors: Dethier David P. , et al.
Published: July 2023

Supplemental data and figures for Dethier et al. Lake Devlin paper.
Elemental Sulfur and Its Isotopic Composition in the Black Sea Water
Authors: Dubinin A. V. , Demidova T. P. , Semilova L. S. , Rimskaya-Korsakova M. N. , Dubinina E. O. , Kossova S. A. , Zologina E. N.
Published: July 2023

As one of the main intermediate products of hydrogen sulfide oxidation, elemental sulfur plays an important indicator role in understanding the oxidative cycle of sulfur in the water of anoxic basins. The distribution of elemental sulfur in the water column of the Black Sea at stations located in the area of the continental slope is considered. For the first time, the concentration distributions of two forms of elemental sulfur depending on the depth in the Black Sea water were obtained: suspended elemental sulfur with a fraction of more than 0.45 μm (S0) and zero-valency sulfur (ZVS), which includes the sum of elemental sulfur (suspended and colloidal) and polysulfide sulfur. In the upper anoxic waters, the concentration of S0 noticeably increases (almost 200 times relative to the depth of 400 m) with an increase in the concentration of hydrogen sulfide and the density of water. At depths of more than 250 m, the concentration of both forms of sulfur remains almost constant (ZVS = 0.21 ± 0.03 µmol/kg, S0 = 0.05 ± 0.01 µmol/kg). A sharp increase in the concentration of S0 at the depths of 150–250 m is associated with the oxidation of hydrogen sulfide due to bacterial anoxygenic photosynthesis after sampling. The value of δ34S(ZVS) was determined in the waters of two stations Ash-26 and 149 at the depths of 450 and 600 m, respectively, which turned out to be +2.2‰ higher than δ34S(Н2S) from the same depths, which indicates the bacterial origin of elemental sulfur.
Supplementary Table S2 from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

Univariable and multivariable analyses for OS from the AURA3 trial (ctDNA evaluable population, n = 291) and FLAURA trial (ctDNA evaluable population, n = 499).
Supplementary Figure S5 from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

FLAURA flow diagram for ctDNA analysis (n = 499). Clearance refers to non-detectable plasma EGFRm, where EGFRm was detectable at baseline. *There were 3 patients in the osimertinib arm and 7 patients in the comparator EGFR-TKI arm without a valid ddPCR result at Weeks 3 and 6; these samples were excluded from the ctDNA clearance analysis. Abbreviations: ctDNA, circulating tumor DNA; EGFRm, epidermal growth factor receptor mutation (ex19del or L858R); TKI, tyrosine kinase inhibitor.
Data from Early Clearance of Plasma Epidermal Growth Factor Receptor Mutations as a Predictor of Outcome on Osimertinib in Advanced Non–Small Cell Lung Cancer; Exploratory Analysis from AURA3 and FLAURA
Authors: Gray Jhanelle E. , Ahn Myung-Ju , Oxnard Geoffrey R. , Shepherd Frances A. , Imamura Fumio , Cheng Ying , Okamoto Isamu , Cho Byoung Chul , Lin Meng-Chih , Wu Yi-Long , Majem Margarita , Gautschi Oliver , Boyer Michael , Bulusu Krishna C. , Markovets Aleksandra , Barrett J. Carl , Hodge Rachel , McKeown Astrid , Hartmaier Ryan J. , Chmielecki Juliann , Papadimitrakopoulou Vassiliki A. , Ramalingam Suresh S.
Published: July 2023

AbstractPurpose:
Plasma circulating tumor DNA (ctDNA) analysis is used for genotyping advanced non–small cell lung cancer (NSCLC); monitoring dynamic ctDNA changes may be used to predict outcomes.
Patients and Methods:
This was a retrospective, exploratory analysis of two phase III trials [AURA3 (NCT02151981), FLAURA (NCT02296125)]. All patients had EGFR mutation-positive (EGFRm; ex19del or L858R) advanced NSCLC; AURA3 also included T790M-positive NSCLC. Osimertinib (FLAURA, AURA3), or comparator EGFR–tyrosine kinase inhibitor (EGFR-TKI; gefitinib/erlotinib; FLAURA), or platinum-based doublet chemotherapy (AURA3) was given. Plasma EGFRm was analyzed at baseline and Weeks 3/6 by droplet digital PCR. Outcomes were assessed by detectable/non-detectable baseline plasma EGFRm and plasma EGFRm clearance (non-detection) at Weeks 3/6.
Results:
In AURA3 (n = 291), non-detectable versus detectable baseline plasma EGFRm had longer median progression-free survival [mPFS; HR, 0.48; 95% confidence interval (CI), 0.33–0.68; P < 0.0001]. In patients with Week 3 clearance versus non-clearance (n = 184), respectively, mPFS (months; 95% CI) was 10.9 (8.3–12.6) versus 5.7 (4.1–9.7) with osimertinib and 6.2 (4.0–9.7) versus 4.2 (4.0–5.1) with platinum-pemetrexed. In FLAURA (n = 499), mPFS was longer with non-detectable versus detectable baseline plasma EGFRm (HR, 0.54; 95% CI, 0.41–0.70; P < 0.0001). For Week 3 clearance versus non-clearance (n = 334), respectively, mPFS was 19.8 (15.1 to not calculable) versus 11.3 (9.5–16.5) with osimertinib and 10.8 (9.7–11.1) versus 7.0 (5.6–8.3) with comparator EGFR-TKI. Similar outcomes were observed by Week 6 clearance/non-clearance.
Conclusions:
Plasma EGFRm analysis as early as 3 weeks on-treatment has the potential to predict outcomes in EGFRm advanced NSCLC.
Supplementary Figure 8 from Kinase inhibitor pulldown assay identifies a chemotherapy response signature in triple negative breast cancer based on purine-binding proteins
Authors: Wang Junkai , Saltzman Alexander B , Jaehnig Eric J , Lei Jonathan T. , Malovannaya Anna , Holt Matthew V. , Young Meggie N. , Rimawi Mothaffar F. , Ademuyiwa Foluso O. , Anurag Meenakshi , Kim Beom-Jun , Ellis Matthew J.
Published: July 2023

Supplementary Figure 8
Supplementary Figure 2 from Kinase inhibitor pulldown assay identifies a chemotherapy response signature in triple negative breast cancer based on purine-binding proteins
Authors: Wang Junkai , Saltzman Alexander B , Jaehnig Eric J , Lei Jonathan T. , Malovannaya Anna , Holt Matthew V. , Young Meggie N. , Rimawi Mothaffar F. , Ademuyiwa Foluso O. , Anurag Meenakshi , Kim Beom-Jun , Ellis Matthew J.
Published: July 2023

Supplementary Figure 2
Supplementary Figure 1 from Kinase inhibitor pulldown assay identifies a chemotherapy response signature in triple negative breast cancer based on purine-binding proteins
Authors: Wang Junkai , Saltzman Alexander B , Jaehnig Eric J , Lei Jonathan T. , Malovannaya Anna , Holt Matthew V. , Young Meggie N. , Rimawi Mothaffar F. , Ademuyiwa Foluso O. , Anurag Meenakshi , Kim Beom-Jun , Ellis Matthew J.
Published: July 2023

Supplementary Figure 1
Data from Kinase inhibitor pulldown assay identifies a chemotherapy response signature in triple negative breast cancer based on purine-binding proteins
Authors: Wang Junkai , Saltzman Alexander B , Jaehnig Eric J , Lei Jonathan T. , Malovannaya Anna , Holt Matthew V. , Young Meggie N. , Rimawi Mothaffar F. , Ademuyiwa Foluso O. , Anurag Meenakshi , Kim Beom-Jun , Ellis Matthew J.
Published: July 2023

Abstract
Triple negative breast cancer (TNBC) constitutes 10-15% of all breast tumors. The current standard of care is multiagent chemotherapy, which is effective in only a subset of patients. The original objective of this study was to deploy a mass spectrometry (MS)-based kinase inhibitor pulldown assay (KIPA) to identify kinases elevated in non-pCR (pathological complete response) cases for therapeutic targeting. Frozen optimal cutting temperature compound (OCT)-embedded core needle biopsies were obtained from 43 TNBC patients before docetaxel and carboplatin-based neoadjuvant chemotherapy. KIPA was applied to the native tumor lysates that were extracted from samples with high tumor content. Seven percent of all identified proteins were kinases, and none were significantly associated with lack of pCR. However, among a large population of “off-target” purine-binding proteins (PBP) identified, seven were enriched in pCR-associated samples (p < 0.01). In orthogonal mRNA-based TNBC datasets, this seven-gene “PBP signature” was associated with chemotherapy sensitivity and favorable clinical outcomes. Functional annotation demonstrated gamma interferon response, nuclear import of DNA repair proteins and cell death associations. Comparisons with standard tandem mass tagged (TMT)-based discovery proteomics performed on the same samples demonstrated that KIPA-nominated pCR biomarkers were unique to the platform. KIPA is a novel biomarker discovery tool with unexpected utility for the identification of purine-binding proteins related to cytotoxic drug response. The PBP signature has the potential to contribute to clinical trials designed to either escalate or de-escalate therapy based on pCR probability.
Soluble (Pro)Renin Receptor Level in Patients with Severe Obesity Is Associated with Visceral Adiposity and Is Involved with Insulin Resistance and Renal Injury
Authors: Yamaguchi Takashi , Morimoto Satoshi , Suda Chikahito , Ichihara Atsuhiro , Ishihara Noriko , Nakamura Shoko , Tanaka Sho , Watanabe Yasuhiro , Imamura Haruki , Ohira Masahiro , Shimizu Naomi , Saiki Atsuhito , Tatsuno Ichiro
Published: July 2023

Introduction: High soluble (pro)renin receptor (s[P]RR) level in circulation is reported in obese patients; however, it is unclear which body composition components are responsible for it. In this study, the authors examined blood s(P)RR levels and ATP6AP2 gene expression levels in visceral and subcutaneous adipose tissue (VAT, SAT) in severely obese patients who underwent laparoscopic sleeve gastrectomy (LSG), with the aim of clarifying the relationship with body composition and metabolic factors. Methods: Seventy five cases who underwent LSG between 2011 and 2015 and were postoperatively followed-up for 12 months at the Toho University Sakura Medical Center were included in the analysis of the cross-sectional survey at baseline, and 33 cases were included in the analysis of the longitudinal survey during the 12 months after LSG. We evaluated body composition, glycolipid parameters, liver/renal function, as well as serum s(P)RR level and ATP6AP2 mRNA expression level in VAT and SAT. Results: The mean serum s(P)RR level at baseline was 26.1 ng/mL, this value was considered higher than values in healthy subjects. There was no significant difference in the expression level of ATP6AP2 mRNA between VAT and SAT. At baseline, multiple regression analysis for the association between s(P)RR and variables identified that visceral fat area, HOMA2-IR, and UACR showed the independent relationships with s(P)RR. During the 12 months after LSG, body weight, serum s(P)RR level showed a significant decrease (from 30.0 ± 7.0 to 21.9 ± 4.3). Multiple regression analysis for the association between the change in s(P)RR and variables showed that changes in visceral fat area, and alanine transaminase were independently related to the change in s(P)RR. Conclusion: This study showed that blood s(P)RR level was high in severely obese patients, decreased with weight loss by LSG, and was associated with visceral fat area in both pre- and postoperative changes. The results suggest that blood s(P)RR levels in obese patients may reflect the involvement of visceral adipose (P)RR in insulin resistance and renal damage mechanisms associated with obesity.
Discontinuation of Renin-Angiotensin-Aldosterone System Inhibitors Secondary to Hyperkalemia Translates into Higher Cardiorenal Outcomes
Authors: An Jaejin , Zhou Hui , Ni Liang , Harrision Teresa N , Wei Rong , Agiro Abiy , Brahmbhatt Yasmin Ghanshyam , Oluwatosin Yemmie , Schilling Craig G. , Sim John J.
Published: July 2023

Introduction: Discontinuation of renin-angiotensin-aldosterone system inhibitor (RAASi) is common after hyperkalemia. We evaluated the risk of kidney and mortality outcomes associated with RAASi discontinuation among patients with chronic kidney disease (CKD) and hyperkalemia. Methods: We identified adult patients with CKD (eGFR <60 mL/min/1.73 m2) who experienced new-onset hyperkalemia (potassium ≥5.0 mEq/L) between 2016 and 2017 from Kaiser Permanente Southern California and followed them through 2019. We defined treatment discontinuation as having ≥90-day gap in refills of all RAASi within 3 months after hyperkalemia. We used multivariable Cox proportional hazards models to evaluate the association between RAASi discontinuation and the primary composite outcome of kidney (≥40% eGFR decline, dialysis, kidney transplant) or all-cause mortality. We evaluated cardiovascular events and recurrence of hyperkalemia as secondary outcomes. Results: Among 5,728 patients (mean age 76 years), 13.5% discontinued RAASi within 3 months after new-onset hyperkalemia. During the median 2 years of follow-up, 29.7% had the primary composite outcome (15.5% with ≥40% eGFR decline, 2.8% dialysis or kidney transplant, 18.4% all-cause mortality). Patients who discontinued RAASi had a higher all-cause mortality compared with those who continued RAASi (26.7% vs. 17.1%) but had no differences in kidney outcomes, cardiovascular events, and recurrence of hyperkalemia. RAASi discontinuation was associated with a higher risk of kidney or all-cause mortality composite outcome (adjusted hazard ratio [aHR] 1.21, 95% CI: 1.06, 1.37) mainly driven by all-cause mortality (aHR: 1.34, 95% CI: 1.14, 1.56). Conclusion: RAASi discontinuation after hyperkalemia was associated with worsened mortality, which may underscore the benefits of continuing RAASi among patients with CKD.
Sleep Duration Is Associated With Subclinical Carotid Plaque Burden
Authors: Agudelo Christian , Ramos Alberto R. , Gardener Hannah , Cheung Ken , Elkind Mitchell S.V. , Sacco Ralph L. , Rundek Tatjana
Published: July 2023

BACKGROUND:

Sleep duration is associated with stroke risk and is 1 of 8 essential components of cardiovascular health according to the American Heart Association. As stroke disproportionately burdens Black and Hispanic populations in the United States, we hypothesized that long and short sleep duration would be associated with greater subclinical carotid atherosclerosis, a precursor of stroke, in the racially and ethnically diverse NOMAS (Northern Manhattan Study).

METHODS:

NOMAS is a study of community-dwelling adults. Self-reported nightly sleep duration and daytime sleepiness were collected between 2006 and 2011. Carotid plaque presence, total plaque area, and intima-media thickness were measured by ultrasound between 1999 and 2008. Linear and logistic regression models examined the cross-sectional associations of sleep duration groups (primary exposure) or daytime sleepiness (secondary exposure) with measures of carotid atherosclerosis. Models adjusted for age, time between ultrasound and sleep data collection, sex, race and ethnicity, education, health insurance, smoking, alcohol use, physical activity, body mass index, hypertension, diabetes, hypercholesterolemia, and cardiac disease.

RESULTS:

The sample (n=1553) had a mean age of 64.7±8.5 years and was 61.9% female, 64.8% Hispanic, and 18.2% non-Hispanic Black. Of the sample, 55.6% had carotid plaque, 22.3% reported nightly short sleep (<7 hours), 66.6% intermediate sleep (≥7 and <9 hours), and 11.1% had long sleep (≥9 hours). Compared with intermediate sleep, long sleep was associated with greater odds of carotid plaque presence relative to plaque absence (odds ratio, 1.6 [95% CI, 1.1–2.4]) and larger total plaque area (odds ratio, 1.4 [95% CI, 1.0–1.9]) after full covariate adjustment. Short sleep and daytime sleepiness were not significantly associated with any carotid measures.

CONCLUSIONS:

The association between long sleep and subclinical carotid atherosclerosis may explain prior associations between long sleep and stroke.
3. Louise Florence Pétronille Tardieu d’Esclavelles d’Épinay
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
13. Beate Barbara Juliane Freifrau von Krüdener
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
14. Anne Louise Germaine, Baronne de Staël-Holstein
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
15. Constance Marie Pipelet or Constance, Princesse de Salm
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
22. Marceline Félicité Josèphe Desbordes-Valmore
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
23. Hortense Thérèse Sigismonde Sophie Alexandrine Allart de Méritens
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
29. Julienne Joséphine Gauvin [Juliette Drouet]
Authors: Isbell John Claiborne
Published: July 2023

Destins de femmes is the first comprehensive overview of French women writers during the turbulent period of 1750-1850. John Isbell provides an essential collection that illuminates the impact women writers had on French literature and politics during a time marked by three revolutions, the influx of Romantic art, and rapid technological change.

Each of the book’s thirty chapters introduces a prominent work by a different female author writing in French during the period, from Germaine de Staël to George Sand, from the admired salon libertine Marie du Deffand to Flora Tristan, tireless campaigner for socialism and women’s rights. Isbell draws from multi-genre writers working in prose, poetry and correspondence and addresses the breadth of women’s contribution to the literature of the age. Isbell also details the important events which shaped the writers’ lives and contextualises their work amidst the liberties both given and taken away from women during the period.

This anthology fills a significant gap in the secondary literature on this transformative century, which often overlooks women who were working and active. It invites a further gendered investigation of the impact of revolution and Romanticism on the content and nature of French women’s writing, and will therefore be appropriate for both general readers, students, and academics analysing history and literature through a feminist lens.
Association between dietary anthocyanidins intake and depression among US adults: a cross-sectional study (NHANES, 2007–2010 and 2017–2018)
Authors: Chen Wen-li , Zhao Jing
Published: July 2023

Background

Anthocyanidins encompass a diverse array of compounds that possess notable anti-inflammatory and antioxidant properties with pharmacological activity. However, the correlation between the consumption of anthocyanidins through diet and its impact on depression has yet to be investigated.

Methods

This study utilized the Food and Nutrient Database for Dietary Studies (FNDDS) expanded flavonoid intake database, as well as data from the National Health and Nutrition Examination Survey (NHANES) from the years 2007 to 2010 and 2017 to 2018. The analysis of the collected data was conducted in R, following the guidelines outlined in the official NHANES user guide “Stratified Multi-stage Probability Sampling”. Three different models were developed using logistic regression to assess the protective effects of T3 (representing the highest intake of anthocyanidins) against depression. Additionally, the study aimed to investigate whether there existed a non-linear relationship between the dietary intake of anthocyanidins and the prevalence of depression by employing restricted cubic spline (RCS) analysis.

Results

A total of 6,845 eligible participants were included in this cross-sectional study, with their data appropriately weighted to represent a population of 89.8 million people in the United States of America. The results demonstrated that individuals diagnosed with depression had a significantly lower dietary intake of anthocyanidins compared to those without depression (P < 0.0001). Moreover, significant differences were observed among different participant groups regarding socioeconomic status and the presence of chronic physical illnesses (such as hypertension, glucose status, and chronic kidney disease risk, etc.) (P < 0.05). After adjustment for covariates, participants with the highest intake of anthocyanins (T3) demonstrated a significantly reduced risk of depression [ORT3 = 0.67, 95%CI: (0.48–0.95), (Ptrend= 0.02]. Furthermore, the RCS analysis revealed a significant linear relationship between dietary anthocyanidin intake and depression (P for non-linear = 0.5876).

Conclusion

Our findings reveal a negative association between dietary anthocyanidin intake and depression.
Reporting a novel growth hormone receptor gene variant in an Iranian consanguineous pedigree with Laron syndrome: a case report
Authors: Bitarafan Fatemeh , Khodaeian Mehrnoosh , Garrousi Fatemeh , Khalesi Raziyeh , Ghazi Nader Donya , Karimi Behnam , Alibakhshi Reza , Garshasbi Masoud
Published: July 2023

Background

Human growth hormone (hGH) plays a crucial role in growth by binding to growth hormone receptor (GHR) in target cells. Binding of GH molecules to their cognate receptors triggers downstream signaling pathways leading to the transcription of several genes, including insulin-like growth factor (IGF)-1. Pathogenic variants in the GHR gene can result in structural and functional defects in the GHR protein, leading to Laron Syndrome (LS) with the primary clinical manifestation of short stature. So far, around 100 GHR variants have been reported, mostly biallelic, as causing LS.

Case presentation

We report on three siblings from an Iranian consanguineous family who presented with dwarfism. Whole-exome sequencing (WES) was performed on the proband, revealing a novel homozygous missense variant in the GHR gene (NM_000163.5; c.610 T > A, p.(Trp204Arg)) classified as a likely pathogenic variant according to the recommendation of the American College of Medical Genetics (ACMG). Co-segregation analysis was investigated using Sanger sequencing.

Conclusions

To date, approximately 400–500 LS cases with GHR biallelic variants, out of them 10 patients originating from Iran, have been described in the literature. Given the high rate of consanguineous marriages in the Iranian population, the frequency of LS is expected to be higher, which might be explained by undiagnosed cases. Early diagnosis of LS is very important, as treatment is available for this condition.