bluuebunny/crossref_metadata_2025 huggingface dataset:
Laterality and Plasticity of Bone Mineral Density in Vertebral Bodies of Patients with Adolescent Idiopathic Scoliosis
Authors: Makino Takahiro , Takenaka Shota , Sakai Yusuke , Kanie Yuya , KAITO TAKASHI
Published: March 2021

BackgroundThe asymmetrical distribution of bone mineral density (BMD) in vertebral bodies in adolescent idiopathic scoliosis (AIS) has been reported; however, it is still unknown whether BMD asymmetrical distribution can vary by the mechanical environment around each vertebral body. The purpose of this retrospective study was to investigate changes in the asymmetrical distribution of BMD in each vertebral body up to 1 year after posterior spinal corrective fusion surgery (PSF) in patients with AIS.MethodsWe analyzed 75 vertebrae within the non-instrumented lumbar spines of 27 female AIS patients (median age, 16 years; interquartile range [IQR], 14–19 years) who underwent PSF. The BMDs of the vertebral bodies were calculated from 1-week and 1-year postoperative quantitative computed tomography scans and a laterality index (LI = BMD of right half of vertebral bodies / BMD of left half of vertebral bodies). The disc wedging angle was measured preoperatively and at 1 year postoperatively from plain radiographs, and the disc wedging angle index (DWAI) was calculated as the sum of the disc wedging angles of the upper and lower discs adjacent to each vertebra.ResultsThe median BMDs of both the right and left halves of each vertebral body significantly decreased from 1 week postoperatively to 1 year postoperatively (right, 228.3 mg/cm3 hydroxyapatite [IQR, 201.8–251.0 mg/cm3 hydroxyapatite] to 214.8 mg/cm3 hydroxyapatite [IQR, 186.9–241.0 mg/cm3 hydroxyapatite], P < 0.001; left, 229.6 mg/cm3 hydroxyapatite [IQR, 198.7–244.7 mg/cm3 hydroxyapatite] to 206.3 mg/cm3 hydroxyapatite [IQR, 188.0–231.9 mg/cm3 hydroxyapatite], P < 0.001). The preoperative median DWAI was 5.0 (IQR, −12.0–13.0) and the 1-week postoperative LI was 1.01 (IQR, 0.95–1.08); these measures were positively correlated (ρ = 0.827; P < 0.001). The median perioperative change in DWAI was −4 (IQR, −9–10) and the median postoperative change in LI was 0.01 (IQR, −0.02–0.03); these measures were also positively correlated (ρ = 0.741; P < 0.001).ConclusionsThe laterality of BMD in each vertebral body in AIS patients was a plastic phenomenon, was deemed a secondary change due to external loading, and was related to the amount of disc wedging.
Immunomodulatory effects of PI3Kδ inhibition in solid tumors – evaluation in a randomized phase II trial
Authors: Ottensmeier Christian , Eschweiler Simon , Suastegui Ciro Ramirez , King Emma , Chudley Lindsey , Thomas Jaya , Oliver Wood ,   Adrian von Witzleben2, Jeffrey Danielle , McCann Katy , Simon Hayley , Mondal Monalisa , Wang Alice , Lopez-Guadamillas Elena , Li Yingcong , Dobbs Nicola , Essame Louisa , Acton Gary , Kelly Fiona ,   Gavin Halbert8, Sacco Joseph , Schache Andrew , Shaw Richard , McCaul James , Paterson Claire , Davies Joseph , Brennan Peter , Singh Rabindra Rabindra P , Loadman Paul , Wilson William , Hackshaw Allan , Okkenhaug Klaus , Thomas Gareth , Jones Terry , Ay Ferhat , Friberg Greg , Vanhaesebroeck Bart , Vijayanand Pandurangan
Published: March 2021

Phosphoinositide 3-kinase δ (PI3Kδ) plays a key role in lymphocytes and inhibitors targeting this PI3K have been approved for hematological malignancies. While studies in hematological and solid tumor models in mice have demonstrated that PI3Kδ inhibitors (PI3Kδi) can induce anti-tumor immunity, the impact of PI3Kδi on solid tumors in humans remains unclear. Here, we assessed the effects of the PI3Kδi AMG319 in patients with resectable head and neck cancer in a neoadjuvant, double-blind, placebo-controlled randomised phase-II trial. We find that PI3Kδ inhibition decreases tumor-infiltrating immunosuppressive TREG cells and causes heightened cytotoxic potential of tumor-infiltrating CD8+ and CD4+ T cells. Loss of intratumoral TREG cells and an increase in the frequency of activated TREG cells in the blood post-treatment are indicative of systemic effects on TREG tissue retention and maintenance. At the tested AMG319 doses, immune-related adverse events caused treatment discontinuation in 12/21 of AMG319-treated patients, further suggestive of systemic effects on TREG cells. Consistent with this notion, in a murine syngeneic tumor model, PI3Kδi decreased TREG cells in both tumor and non-malignant tissues and affected TREG subtype composition, maintenance and functionality. Our data demonstrate the cancer-immunotherapy potential of PI3Kδ inhibition in humans, but its modulation will need to be carefully balanced to harness its anti-tumor capacity while minimizing immune related toxicity.
A mouse model of neoadjuvant chemotherapy followed by interval cytoreductive surgery indicates impaired efficacy of perioperative cisplatin
Authors: Clark Mitchell , Kollara Alexandra , Brown Theodore , May Taymaa
Published: March 2021

Background
Investigate the impact of interval cytoreductive surgery (ICS) on progression in an orthotopic mouse model of ovarian cancer and the impact of chemotherapy delivered at various timelines following surgery.
Methods
Luciferase-expressing ID8 murine ovarian cancer cells were implanted intra-bursally and IP to C57BL/7 mice. Once disease was established by bioluminescence, 2 cycles of neoadjuvant cisplatin were administered, and animals received either ICS (removal of the injected bursa/primary tumor) or anesthesia alone. Postsurgical chemotherapy was administered on the same day as the intervention (ICS/anesthesia), or on day 7 or day 28 following the intervention. Progression was quantified serially with in vivo bioluminescence imaging. Volume of ascitic fluid volume collected at necropsy was measured.
Results
Animals were matched for tumor burden at stratification. There was no accelerated growth of residual tumor after interval cytoreduction compared to controls. Animals who received chemotherapy on postoperative day (POD) 7 had better disease control compared to standard-of-care POD 28. Animals who underwent surgery had less ascites at necropsy compared to those who had anesthesia alone.
Conclusions
In this animal model, surgical wounding with suboptimal cytoreduction after neoadjuvant chemotherapy did not cause accelerated expansion of residual disease. Surgical wounding appears to impair cisplatin activity when given at time of surgery.
Investigations and improvement of Nickel Sulfide modified electrode material from single source precursor for energy storage application
Authors: Sambathkumar C. , Ranjithkumar R. , Arasi S. Ezhil , Manikandan A. , Nallamuthu N. , Kumar M. Krishna , Arivarasan A. , Devendran P.
Published: March 2021

High-performance energy storage electrode materials are emerging demand in near future for the construction of supercapacitor with high energy and power densities. Herein, Nickel (II) Diethyldithiocarbamate was used as single source precursor for Nickel Sulfide (Ni9S8) two dimensional (2D) nanosheets preparation and hexadecylamine as shape directing agent via simple solvothermal method. The orthorhombic structure of Ni9S8 nanosheets was confirmed by X-ray diffraction (XRD) pattern. Scanning electron microscopy (SEM) and high resolution transmission electron microscopy (HRTEM) images revealed that as-prepared Ni9S8 nanoparticles possess sheet-like morphology. Besides, the thermal stability of Ni(DTC)2 complex was studied by Thermo-gravimetric/Derivative thermo gravimetric(TG/DTG) with Differential scanning calorimetric (DSC) analysis. The electrochemical properties of Ni9S8 nanosheets was studied using galvanostatic charge-discharge (GCD) and cyclic voltammetry (CV) techniques. From the charge-discharge study of Ni9S8 nanosheets, a high specific capacitance of 281 Fg− 1 was obtained at a current density of 1 Ag− 1, and up to 82 % retentivity was achieved after 5000 cycles. Thus, the prepared Ni9S8 nanosheets could be one of the attractive potential active electrode materials for the application of supercapacitor.
Prevalence and intensity of intestinal schistosomiasis among the adult population, and water and sanitation conditions: a community-based cross-section study at Muleba District
Authors: Shabani Monica , Zacharia Abdallah , Mushi Vivian , Joseph Mary , Kinabo Clemence , Makene Twilumba
Published: March 2021

Background

Intestinal schistosomiasis is one of the serious public health problems in all age groups and can lead to considerable morbidity and mortality especially to communities with an inadequate supply of safe water and sanitation services.
Objective

This study was conducted to establish the current burden of intestinal schistosomiasis among adults in the Muleba District and assessment of water and sanitation conditions that might influence the transmission of intestinal schistosomiasis.
Methods

A community-based cross-sectional study was conducted between July and August 2020. A total of 328 stool samples were collected and processed using formal-ether concentration and Kato-Katz methods. Water and sanitation data were collected using a questionnaire interview conducted among participants. Participants were randomly selected from four villages. Data were analyzed by using Statistical Package for the Social Sciences software version 23.
Results

Thirty six participants (11%) were infected with Schistosoma mansoni. The prevalence was higher among the residents of households using water from improved sources, houses without sanitation facilities, and participants who do not use sanitation facilities. We found a significantly increased risk of S. mansoni infection among participants in households without toilet facilities compared with those in households with VIP (OR = 4.10, p = 0.001).
Conclusion

The prevalence of intestinal schistosomiasis infection among the adult population in Muleba indicates a moderate risk of transmission. Type of toilet facility is a significant factor in the perpetuation of Schistosoma mansoni transmission.
Quality-of-life after cholecystectomy in Kazakhstan and Sweden: comparative study based on the GIQLI questionnaire.
Authors: Koishibayeva Leyla Meiramovna , Turgunov Yermek Meiramovich , Sandblom Gabriel , Koishibayev Zhandos Muratovich , Teleuov Murat Koishibayevich
Published: March 2021

Background

As severe morbidity rarely is the focus in gallstone surgery, health-related quality of life has evolved as the main outcome measure of the management of patients with gallstone disease. The lack of universally accepted guidelines on treatment of gallstone disease has also resulted in great regional differences in the preoperative evaluation and management of patients with gallstone disease.
Objective

The aim of this study was to compare quality-of-life following gallstone surgery in cohorts from Kazakhstan and Sweden.
Methods

A comparative study on quality-of-life (QoL) after cholecystectomy (CE) in two cohorts from Sweden and Kazakhstan using the Gastrointestinal Quality-of-Life Index (GIQLI) questionnaire. QoL measures of 259 patients in Kazakhstan and 448 patients in Sweden were compared taking into account surgical approach, mode of admission, and indication for surgery. Patients in both cohorts were requested to fill in the GIQLI questionnaire after surgery. Similar routines were applied to ensure high coverage in both countries.
Results

The mean overall GIQLI score was higher for patients undergoing cholecystectomy in Sweden than those in Kazakhstan (p < 0.01). The same was seen when stratifying for open or laparoscopic surgery (both p < 0.05), absence of presence of acute cholecystitis (both p < 0.05) and emergency admission (p < 0.05), but not in case of planned admission (p = 0.54).
Conclusions

There were large differences in perceived QoL, even when taking indication for surgery and approach into account. These differences in may be explained by differences in attitudes to health status and treatment expectations. Standardized routines for evaluating the outcome after surgery are needed.
Assessing information-sharing networks within small-scale fisheries and the implications for conservation interventions
Authors: Arlidge William , Firth Josh , Alfaro-Shigueto Joanna , Ibanez-Erquiaga Bruno , Mangel Jeffrey , Squires Dale , Milner-Gulland EJ
Published: March 2021

The effectiveness of biodiversity conservation interventions is often dependent on local resource users' underlying social interactions. However, it remains unclear how fine-scale differences in information shared between resource users can influence network structure and the success of behaviour-change interventions. We investigate this knowledge gap by comparing information-sharing networks in a fishing community in Peru where a trial conservation intervention is underway to reduce the incidental capture of sea turtles (bycatch). We show that the general network structure detailing information sharing about sea turtle bycatch differs from other fishing-related information sharing, specifically in degree assortativity (homophily) and eccentricity. This finding highlights that fine-scale differences in the information shared between resource users may influence network structure.
Ulectomia uma alternativa cirúrgica no retardo da erupção dentária: relato de caso
Authors: Souza Cléia Maria de , Martins Leidiane Rezende , Favretto Carla Oliveira
Published: March 2021

O processo de cronologia da erupção dentária é uma parte integrante do crescimento e desenvolvimento infantil. No entanto, o atraso na erupção dos dentes é algo frequente em muitas crianças, sendo necessário o cirurgião-dentista e/ou odontopediatra saber avaliar cada caso. Um dos motivos relacionados a esse atraso é a fibrose gengival, que após uma avaliação clínica e exame radiográfico minuciosos da região, constatando-se ausência de tecido ósseo, opta-se pelo tratamento por meio da técnica de ulectomia, a qual consiste na exérese dos tecidos que revestem a face incisal da coroa dentária de um dente não irrompido, com o objetivo de permitir um caminho livre para esse dente vir a ocupar sua posição na arcada. O objetivo desse trabalho é relatar um caso clínico de não irrupimento dos dentes 11 e 21. A paciente compareceu na policlínica da FAMP com a queixa de ausência dos dentes da frente, que após o exame clínico e radiográfico, observou-se que tratava de um retardo de erupção devido a um fibrosamento gengival e sem osso recobrindo esses dentes. O tratamento proposto foi a ulectomia, com a exposição das incisais desses dentes, propiciando a movimentação eruptiva. A paciente ficou em acompanhamento por 6 meses. Conclui-se que frente a possíveis casos de retardo na erupção, a ulectomia se mostra como uma excelente escolha de tratamento, pela sua técnica simples, de recuperação e resultados rápidos, devolvendo para a paciente função e estética. O cirurgião dentista precisa estar apto para fazer um correto diagnóstico e tratamento nesses casos.
Avaliação de saúde bucal em idosos da Universidade da Maturidade: estudo transversal
Authors: Sera Eduardo Aoki Ribeiro , Osório Neila Barbosa , Ribeiro Emerson Moura , Neto Luiz Sinésio Silva
Published: March 2021

Introdução: A saúde bucal dos idosos pode ser considerado um problema de saúde pública. Objetivo: O estudo descreve o perfil da saúde bucal dos idosos da Universidade da Maturidade (UMA) do campus de Palmas da Universidade Federal do Tocantins (UFT). Materiais e Métodos: O desenho do estudo é do tipo descritivo- transversal. A amostra foi composta por 38 idosos, sendo 28 do sexo feminino e 10 do sexo masculino. Foi aplicado um questionário para medir o conhecimento sobre saúde bucal dos idosos, analisando o índice CPOD e seus componentes. Resultados: O índice do CPOD foi de 57,89%. Em relação às próteses, encontrou-se um percentual de 60,52% usa prótese total e que os acadêmicos participantes da pesquisa 60,52% são endêntulos. No entanto, 93,42% dos idosos conhecem sobre autocuidado odontológico. Conclusão: A partir dos achados da pesquisa, pode-se concluir que o perfil da condição bucal dos idosos neste estudo é inadequado, porém, possuem alto índice de conhecimento de saúde bucal. Sugerimos a incorporação de programas de promoção de saúde e de reabilitação para este segmento da população.
Uso de retalho de gordura de Bichat no fechamento de defeito ósseo pós-enucleação cística: relato de caso
Authors: Souza Neto Heitor Ferreira de , Souza Henrique Lima Ferreira de , Moreno Lara Marques Magalhães , Almeida Renata de Albuquerque Cavalcanti , Nogueira Emerson Filipe de Carvalho
Published: March 2021

Introdução: O coxim adiposo de Bichat é uma massa adiposa lobulada, de fácil acesso, que pode ser utilizada para correção de defeitos ósseos e complicações cirúrgicas por apresentar: menor morbidade ao sítio doador, rica vascularização sanguínea, confiabilidade, altas taxas de sucesso e não deixa cicatrizes visíveis. Objetivo: Relatar um caso clínico de um paciente que apresentou comunicação bucossinusal após exodontia e remoção de cisto periapical em maxila, em que foi utilizada a gordura de Bichat para correção do defeito ósseo. Relato do caso: Paciente do sexo masculino, 52 anos de idade, apresentou queixa de dor em maxila esquerda e sensação de peso em face. Ao exame tomográfico foi observada imagem sugestiva de cárie profunda no 26 e cisto periapical na região. O tratamento consistiu da exodontia, enucleação cística e fechamento do defeito com a gordura de Bichat, sob anestesia geral. Paciente foi acompanhado por 60 dias sem recidiva da lesão. Conclusão: Por apresentar uma rica vascularização, menor morbidade para o sítio doador e baixas taxas de complicações, o corpo adiposo bucal foi utilizado para o tratamento da comunicação bucossinusal e correção do defeito ósseo, assegurando o sucesso do procedimento.
Abordagem intrabucal para exérese de sialolito na glândula sublingual: relato de caso
Authors: Lira Pereira de Castro Carla Cecília , Rodrigues Éwerton Daniel Rocha , Vasconcelos Belmiro Cavalcanti do Egito , Moreira Thaís Cristina Araújo
Published: March 2021

A sialolitíase é uma patologia que afeta as glândulas salivares e tem como patogênese a obstrução dos ductos dessas glândulas, causando uma diminuição do fluxo salivar. O local de acometimento depende da anatomia e de fatores fisiológicos inerentes a cada glândula. O presente estudo tem como objetivo relatar um caso de sialolitíase da glândula sublingual, evidenciando diagnóstico e terapêutica. O relato de caso trata-se de paciente do gênero feminino, 53 anos de idade, melanoderma, apresentou-se ao ambulatório do serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial do Hospital Universitário da Universidade Federal do Piauí, queixando-se de sensação álgica e desconforto associado ao aumento de volume na região sublingual, com sintomatologia aumentada durante as refeições. No exame extrabucal não se observaram alterações. Entretanto, no exame intrabucal podia ser observado um aumento de volume endurecido e consistente à palpação, associado a desconforto. Ao exame radiográfico foi observado uma área radiopaca, circunscrita e com limites bem definidos, sugestiva de sialolito. O tratamento proposto foi a excisão cirúrgica sob anestesia local. Foi realizado bloqueio do nervo lingual e anestesia infiltrativa no soalho bucal (lidocaína 1:100.00 com epinefrina) e incisão póstero-anterior após identificação da área, seguida de dissecção romba. Após a remoção do cálculo, foi realizada a sutura com vicryl 4-0. A paciente foi acompanhada durante 09 meses e observou-se reparo tecidual satisfatório, remissão da sintomatologia e a função normal da glândula. Conclui-se que a abordagem de tratamento depende do tamanho e da localização do sialolito, sendo sempre preferível métodos minimamente invasivos.
Micropores and mass transfer in the formation of myrmekites
Authors: Yuguchi Takashi , Yuasa Haruka , Izumino Yuya , Nakashima Kazuo , Sasao Eiji , Nishiyama Tadao
Published: March 2021

The formation process of myrmekites in granitic rocks can help us to understand the mass transfer between minerals and hydrothermal fluids during the deuteric stage. The Toki granite, central Japan, has three types of myrmekites. Type A myrmekite is defined as a single layer. Type B myrmekite shows a composite texture consisting of two layers, namely, a myrmekite layer and an albite (Ab)-rich layer that is free of vermicular quartz. Type C has a composite texture with the following three layers: two myrmekite layers separated by one Ab-rich layer. Micropores are found in these myrmekites in the undeformed granite, which enable quantitative determinations of the volume decrease during myrmekite formation by measurement of the area of micropores. The areal relationship between the micropores and vermicular quartz in the myrmekites exhibited a high correlation (R2 = 0.8352), thus indicating that the genesis of the micropores is evidently related to myrmekite formation. We derived the reaction equations for myrmekite formation based on the singular value decomposition method. The matrices for singular value decomposition involve the following volume factors: volume change during the reaction and volume ratios of the product minerals. The singular value decomposition indicates that the myrmekites are produced through the consumption of plagioclase and K-feldspar with an inflow of H4SiO4, Na+, and H+ from the hydrothermal fluid, accompanied by an outflow of Al3+, Ca2+, and K+ into the fluid, which constitute essential mass transfers during myrmekite formation. The difference of pH in the hydrothermal fluid and inflow amounts of H4SiO4 and Na+ can explain the reason why micropores occur in the myrmekites but not in the Ab-rich rim (layer); the smaller inflow of H4SiO4 and Na+ from the hydrothermal fluid with lower pH conditions yielded micropore production during myrmekitization, and the larger inflow of H4SiO4 and Na+ from the hydrothermal fluid with higher pH conditions yielded the formation of the Ab-rich rim (layer) with few micropores. The sequential variations in the chemical characteristics of the hydrothermal fluid during the sub-solidus conditions were characterized by a gradual decrease in H4SiO4 (Si4+), Fe2+, Mn2+, Mg2+, and Na+ and a gradual increase in Ca2+, K+, H+, and F–.
Commercialization of conventional and sustainability-oriented innovations: a comparative systematic literature review
Authors: Kalmakova Dinara , Bilan Yuriy , Zhidebekkyzy Aknur , Sagiyeva Rimma
Published: March 2021

Innovations play an important role in achieving competitiveness and long-term economic growth at all levels of the economic hierarchy. More recently, the role of sustainability-oriented innovation in achieving economic growth has become equally important. However, there is a scientific debate about the possibility of effective commercialization of sustainability-oriented innovations. The existence of such scientific debate, as well as the absence of citation-based systematic literature reviews, became a prerequisite for conducting a comparative literature review of research on the effective commercialization of conventional and sustainability-oriented innovations. The purpose of the study is to conduct a comparative review and analysis of research on the commercialization efficiency of conventional and sustainability-oriented innovations. The analysis was conducted on the basis of a citation-based systematic literature review method. The results show that sustainable innovation research is more focused on the relationship between commercialization and firm performance. In the field of conventional innovations, research trends have shifted from studying the impact of technology transfer office (TTO) size, staffing, compensation practices to how strategic factors affect the efficiency of commercialization. In the area of sustainability-oriented innovation, the issues of the strategic orientation impact cause the most sustained interest, while managerial concerns and the stringency of environmental regulations have been actively explored in the past few years. It was revealed that the commercialization efficiency of sustainability-oriented innovations is characterized by so called sustainability-oriented criteria. A distinctive output criterion for commercialization efficiency of sustainability-oriented innovation is the improvement of the firm’s image. In addition, content analysis identified possible research directions to be investigated.
Design and implementation of an optical fiber sensing based vibration monitoring system
Authors: Sun Shuyan , Liu Yun , Sharaf Eldean Mohamed A.
Published: March 2021

Vibration analysis is generally used in the industries for condition monitoring of various electromechanical equipment. For the predictive maintenance of the industry equipment, several techniques have been applied which are based on capacitive and piezoelectric accelerometers. However, they possess several real time problems due to the negative influence of electromagnetic interference. The major problem lies in the detection and transmission of various physical parameters in the noisy and harsh environment. In order to solve the weak points of commonly used structural vibration detection sensors that are easily affected by the harsh environment of the engineering site, the principle of optical fiber sensing is studied, and the system optical path is designed based on MZ interference technology. In this work, a special data acquisition and processing software is developed to acquire the sensed data and the vibration detection is carried out on the steel cantilever structure pasted with fiber optic sensors. Extraction using FFT and pattern recognition through bp neural network yields the system accuracy rate of 96.7 %. The proposed interference type optical fiber technology provides a novel approach for real-time monitoring of engineering structure vibration laying the foundation for the research of intelligent buildings.
Strategizing of the Tourism and Trade Show Industries in Kuzbass Region
Authors: Chotua I. Z. , Khvorostyanaya A. S. , Sadovnichaya A. V. , Pyatovskiy A. A. , Yumatov K. V. , Baranov A. S. , Shevchuk A. V. , Dobryanskiy A. S. , Kvint Vladimir , Kalinskiy O. I. , Mikhailova O. Y. , Egorova A. I.
Published: March 2021

The collective monograph "Strategizing of the Tourism and Trade Show Industries in Kuzbass Region" of the Library "Kuzbass Region Strategy" is a tourism and trade show industries comprehensive study that is of strategic importance in the Kuzbass Region economy. Kuzbass Region strategic branding, the development of which is based on rich cultural, historical, recreational, industrial potential and extensive experience of economic relations with adjacent regions, is considered as an effective tool of positioning and promotion of the region on the Russia and the world tourist map.
Strategizing of Kuzbass Region water resources
Authors: Sasaev N. I. , Zadorozhnaya G. V. , Alabina T. A. , Boiko K. V. , Brel O. A. , Voronin V. L , Gavrilina D. N. , Gribelyuk L. A. , Egorova A. I. , Zaytseva A. I. , Kvint Vladimir , Krikota S. N. , Kurteev V. V. , Luzyanin S. L. , Makarov K. A. , Merzlikina J. B. , Midov A. Z. , Myaskov A. V. , Novikova I. V. , Osipova M. O. , Savelyeva L. N. , Tkachenko I. S. , Tkachenko S. N. , Khvorostyanaya A. S. , Tsarev M. A. , Shevchuk A. V. , Shimko T. G.
Published: March 2021

The collective monograph "Strategizing of Kuzbass Region water resources" proposes strategic directions for the efficient use of water resources and ensuring the strategic security of the region's most important life support system in the long term, primarily through the development of water supply and sanitation systems aimed at achieving the key goal of improving the level and quality of life of the population Kuzbass Region.
Maxillofacial management of dog bites injuries in an infant: a case report
Authors: Ardila Medina Carlos Martín , Contreras-Gómez Natalia , Alvarez-Martinez Efrain
Published: March 2021

Dog bites cause complex craniomaxillofacial injuries. Considering that the bite injuries are repeatedly situated on the face, dentist requires being well known with the therapy of animal bites. A three-year-old male child was attended as a victim of a Pit Bull terrier biting. The patient had multiple wounds at the level of the upper eyelid of the right eyeball, left hemisphere with the involvement of the auricular pavilion, wounds with multiple detachments on face and scalp, several abrasions and ecchymoses in the bilateral infraorbital and mouth region. The clinical intervention was completed in the first twenty-four hours after injury. The affected zones were cleaned and irrigated with saline solution, and the wounds were sutured in layers. Tetanus and anti-rabies vaccination, and antibiotic and analgesic were administered. On the fifth postoperative day, the stitches were removed, and the patient was discharged from the hospital. One week after the trauma, the child showed adequate wound curing absent of aggravation. Satisfactory aesthetic and functional results were achieved. Besides, in this case, the most relevant aspects of the management of dogs bites are presented.
Evaluation and spatial-temporal evolution of water resources carrying capacity in Dongting Lake Basin
Authors: Deng Zhenghua , Dai Liqi , Deng Bing , Tian Xiaoyong
Published: March 2021

A three-dimensional rating index system for water resources system–water environment system–socioeconomic system is constructed based on data from Hunan Dongting Lake Eco-environment Monitoring Center, Hunan Provincial Water Resources Bulletin, and Hunan Statistical Yearbook. The water resources carrying capacity (WRCC) of Dongting Lake Basin from 2009 to 2018 is evaluated by the TOPSIS model combined with analytic hierarchy process (AHP) and entropy weight, and then the temporal evolution and spatial distribution characteristics of the WRCC of the Dongting Lake Basin are analyzed. The results show that: (1) The WRCC in the Dongting Lake Basin decreases from a good level to a reasonable level during the period. Among them, the WRCC of the Ouchi River, Hudu River, and Songzi River Basins decreases significantly. (2) There are obvious spatial differences in the WRCC of the Dongting Lake Basin in 2018, the WRCC order is Lishui River, West Dongting Lake, Zijiang River, South Dongting Lake, Yuanshui River, Xiangjiang River, East Dongting Lake, Songzi River, Hudu River, Ouchi River, with scores of 0.586, 0.526, 0.472, 0.448, 0.416, 0.397, 0.393, 0.313, 0.306, and 0.304, respectively. Finally, some policy recommendations for improving the WRCC of the Dongting Lake Basin are proposed.
Synergistic effect of carboxyl and sulfate groups for effective removal of radioactive strontium ion in a Zr-metal-organic framework
Authors: Ren Lin , Zhao Xudong , Liu Baosheng , Huang Hongliang
Published: March 2021

Rapid removal of radioactive strontium from nuclear wastewater is of great significance for environmental safety and human health. This work reports the effective adsorption of strontium ion in a stable dual-group metal-organic framework, Zr6(OH)14(BDC-(COOH)2)4(SO4)0.75 (Zr-BDC-COOH-SO4), which contains strontium-chelating groups (-COOH and SO4) and a strongly ionizable group (-COOH). Zr-BDC-COOH-SO4 exhibits very rapid adsorption kinetics (<5 min) and a maximum adsorption capacity of 67.5 mg g−1. The adsorption behaviors can be well fitted to the pseudo-second-order model and the Langmuir isotherm model. Further investigations indicate that the adsorption of Sr2+ onto Zr-BDC-COOH-SO4 would not be obviously affected by solution pH and adsorption temperature. The feasible regeneration of the adsorbent was also demonstrated using a simple elution method. Mechanism investigation suggests that free -COOH contributes to the rapid adsorption based on electrostatic interaction, while the introduction of -SO4 significantly enhanced the adsorption capacity. Thus, these results suggest that Zr-BDC-COOH-SO4 is a potential candidate for Sr2+ removal. They also introduce dual groups as an effective strategy for designing high-efficiency adsorbents.
Historical aspects of assessment of the level and measures of prevention of occupation pathologies in Russia
Authors: Romanova Aliona Dmitrievna
Published: March 2021

This article is a review of the scientific literature, during which the main stages of the formation and development of professional pathology, as well as the features of its formation on the territory of the Russia were established and studied
In silico Screening of Phytoconstituents with Antiviral Activities Against SARS-COV-2 Main Protease, Nsp12 Polymerase, and Nsp13 Helicase Proteins
Authors: James Jainey Puthenveettil , Jyothi Divya , Priya Sneh
Published: March 2021

Aims:

The present study aimed to analyse the molecular interactions of the
phytoconstituents known for their antiviral activity with the SARS-CoV-2 nonstructural proteins
such as main protease (6LU7), Nsp12 polymerase (6M71), and Nsp13 helicase (6JYT). The
applied in silico methodologies were molecular docking and pharmacophore modeling using
Schrodinger software.

Methods:

The phytoconstituents were taken from PubChem, and SARS-CoV-2 proteins were
downloaded from the protein data bank. The molecular interactions, binding energy, ADMET
properties, and pharmacophoric features were analysed by glide XP, prime MM-GBSA, qikprop,
and phase application of Schrodinger, respectively. The antiviral activity of the selected
phytoconstituents was carried out by PASS predictor online tools.

Results:

The docking score analysis showed that quercetin 3-rhamnoside (-8.77 kcal/mol) and
quercetin 3-rhamnoside (-7.89 kcal/mol) were excellent products to bind with their respective
targets such as 6LU7, 6M71, and 6JYT. The generated pharmacophore hypothesis model validated
the docking results, confirming the hydrogen bonding interactions of the amino acids. The PASS
online tool predicted constituent's antiviral potentials.

Conclusion:

The docked phytoconstituents showed excellent interactions with the SARS-CoV-2
proteins, and on the outset, quercetin 3-rhamnoside and quercetin 7-rhamnoside interacted well
with all the three proteins; these belong to the plant Houttuynia cordata. The pharmacophore
hypothesis has revealed the characteristic features responsible for their interactions, and PASS
prediction data has supported their antiviral activities. Thus, these natural compounds could be
developed as lead molecules for antiviral treatment against SARS-CoV-2. Further in-vitro and invivo
studies could be carried out to provide better drug therapy.
Speech therapy strategies to promote the vocal health of teachers: integrative literature review
Authors: Santos Rayane Medeiros dos , Cavalcante Mylena dos Santos , Porto Vanessa Fernandes de Almeida , Morais Edna Pereira Gomes de
Published: March 2021

Objective: To identify the speech therapy strategies used to promote vocal health to teachers of early childhood, elementary and high school, participating in programs/actions for prevention and promotion of vocal health, as well as to describe and analyze their effects through an integrative literature review. Methods: An integrative review was conducted, which consisted of searches in the Lilacs, SciELO, and Medline databases. Inclusion criteria were complete articles available online in any language and year of publication that addressed strategies for promoting vocal health and preventing disorders in the target population, used in vocal health programs/actions with teachers. Results: Of the 624 articles that were included, six were selected to compose the study. It was possible to verify that the most used resources were educational strategies, through programs of guidance and attention to the teacher's vocal health. The results of the interventions were analyzed using self-assessment questionnaires, some of which have been standardized, with validation and adaptation to Brazilian Portuguese. Among practical strategies, exercises involving semi-occluded vocal tract, breathing, relaxation, resistance, and vocal projection, as well as vocal warm-up and cool-down, were the most used. Conclusions: Vocal health programs present diversified strategies, such as time and results analysis. The accurate study allowed to verify that the programs are effective and allow better vocal performance to the teacher, notably, through direct and indirect strategies.
Occurrence of tinnitus and peripheral sensory neuropathy in women during chemotherapy treatment of breast cancer
Authors: Kameo Simone Yuriko , Barbosa-Lima Ricardo , Duarte Josilene Luciene , Amorim Bruno Ferreira , Silva Glebson Moura , Marinho Pabliane Matias Lordelo , Sawada Namie Okino
Published: March 2021

Objective: To analyze the occurrence of tinnitus and peripheral sensory neuropathy in women during breast cancer chemotherapy. Methods: This is a retrospective analytical study with a quantitative approach, performed in medical records of an oncology outpatient service between February 2014 and February 2015, using the toxicities scores of Common Terminology Criteria for Adverse Events (CTCAE). Results: Considering 181 patients with breast cancer who met the inclusion criteria, 49.2% reported tinnitus at some point of the treatment, while 65.1% peripheral sensory neuropathy. In both conditions, the predominant severity score was grade 1, with frequencies of 23.8% and 33.1%, respectively. A significant, positive and weak correlation was observed between the severity of tinnitus and peripheral sensory neuropathy (ρ = 0.325 and p = 0.001), as well as very weak between the number of complete cycles of chemotherapy and tinnitus (ρ = 0.195 and p = 0.009) and neuropathy peripheral sensory (ρ = 0.237 and p = 0.002). Conclusions: Tinnitus and peripheral sensory neuropathy were frequent toxicities during chemotherapy treatment of breast cancer, and both manifested with low severity/functional impact in most participants.
The teaching of bioethics in medical school
Authors: Lopes Filho Gaspar de Jesus
Published: March 2021

The extraordinary technological development that occurred in the last fifty years, in which Medicine has evolved more than in the previous fifty centuries, has given rise to several questions of an ethical nature. Since the second half of the last century, there has been a growing perception that doctors are increasingly distant from their patients, prioritizing, at most, the technical aspect of the profession. Bioethics emerged to help humanity to act in a balanced way in the face of environmental and behavioral changes arising from technological evolution.
What have we learned from the pandemic?
Authors: Aleluia Iêda Maria Barbosa
Published: March 2021

With the advent of the COVID-19 pandemic, the entire education process in the health professions had to be rethought.Initially, the effort was to maintain quality education in the remote modality. Adapt curricular matrices, class schedules, train teachers for the new reality, review the capacity of computer systems to support changes and increase access, identify digital platforms appropriate to the needs of institutions, reevaluate teaching and assessment methodologies ... in short, a tremendous task force to deal with the new moment.
Association between weight loss and reduced use of antihypertensive, hypoglycemic, psychotropic, and lipid-lowering drugs in patients undergoing bariatric surgery
Authors: Pereira Gonçalves Mariana Mendes , Daldegan Frederico , Iannuzzi Gabriel Correia , Rodrigues Marcelo Mendonça , Jesus-Silva Seleno Glauber de
Published: March 2021

Objectives: To analyze whether the weight reduction observed in bariatric surgery (Roux-en-Y gastric bypass; BGYR) is accompanied by a reduction in the use of antihypertensive, hypoglycemic, antilipidemic, and psychotropic drugs after 6 and 12 months. Methods: Longitudinal, retrospective study of 100 adult patients undergoing RYGB from May 2015 to January 2019, by laparotomy or laparoscopy. Data on age, body mass index (BMI), and the number of drugs used were recorded 6 and 12 months after surgery. Results: The mean age was 39.7 ± 9.7 years, and the majority were female (n = 78). The mean preoperative BMI was 43.7 ± 5.1 kg/m2, and the mean reduction in BMI after 6 months was 12.1 kg/m2 and 14.9 kg/m2 after 12 months. The reduction in antihypertensive drugs was 65.2% after 6 months and 96% after 12 months. The reduction in 6 months of hypoglycemic agents was 84.3%, and in 12 months, 98.3%. The average reduction in antidyslipidemic drugs was 86.7% in 6 months, and there was no record of using this medication after 12 months. Psychotropics showed a temporary reduction in use after 6 months with a return to levels close to the baseline after 1 year.There was no correlation between the variation in BMI and the use of drugs. Conclusions: there was a significant reduction in the use of drugs after 6 and 12 m, except for psychotropic drugs. The reduction in the use of drugs was not correlated with a reduction in BMI.
Drug-related female autointoxication registered at a toxicology care center
Authors: Sousa Maria Beatriz de , Lini Renata Sano , De Oliveira Magda Lúcia Félix , Mossini Simone Aparecida Galerani
Published: March 2021

Objective: To analyze the data on epidemiological records of autointoxication reports registered at a toxicological assistance center. Methods: Exploratory, descriptive, and retrospective study with the analysis of secondary data, conducted from the audit on Toxicological Occurrence Notification and Attendance forms, referring to the period from 2014 to 2018, filed in a toxicological information and assistance center, located in a municipality in southern Brazil. The data obtained were compiled in spreadsheets and analyzed using simple descriptive statistics. Results: 2,942 epidemiological records on women's autointoxication were audited, 72.0% of the total cases in the period studied. The predominant age group was 18 to 29 years old, with 1697 (57.7%) cases. The main toxic agent was medication, and the only agent of intoxication in 2,358 cases (80.1%). Psychotropic drugs accounted for 55.2% (1,593) of the cases, mainly antiepileptic and psychoanalytic drugs. Clonazepam was present in 567 (35.6%) suicide attempts and as the sole agent in 275 (17.3%) of them. In 873 cases (54.8%), mental illness was reported, in 546 (34.3%) previous suicide attempts, and 1,082 (67.9%) continued use of psychotropic medication. The main outcome was hospital discharge in 1,239 cases (77.8%). Conclusion: The study showed an increase in cases of female autointoxication over the period studied. The high percentage of autointoxication with psychotropic medications may be related to the ease of access at home and society's medicalization.
Determining Priorities in the Aboriginal and Islander Mental Health Initiative for Youth App Second Phase Participatory Design Project: Qualitative Study and Narrative Literature Review (Preprint)
Authors: Povey Josie , Sweet Michelle , Nagel Tricia , Lowell Anne , Shand Fiona , Vigona Jahdai , Dingwall Kylie M
Published: March 2021

BACKGROUND

Digital mental health tools can promote access to culturally safe early intervention mental health services for Aboriginal and Torres Strait Islander young people. Participatory design methodology facilitates user engagement in the co-design of digital resources. However, several challenges have been identified that limit the methodological rigor of this approach.

OBJECTIVE

This paper aims to present an in-depth account of the second phase of participatory design in the development of the Aboriginal and Islander Mental Health Initiative for Youth (AIMhi-Y) app.

METHODS

A first idea storyboard, generated from a formative phase of the AIMhi-Y project, was refined through a series of youth co-design workshops and meetings. A narrative review of the literature, 6 service provider interviews, and engagement with an expert reference group also informed the design process. Generative design activities, storyboarding, discussions, and voting strategies were used.

RESULTS

The participatory design process identified the app features preferred by young people and service providers and assessed their alignment with current recommendations from the scientific literature. Findings from the co-design process are presented across 9 app characteristic domains. Integration of findings into app design proved complex. Although most preferred features identified by young people were included to some degree, other inclusions were restricted by budget, time, and the need to integrate best practice recommendations. A process of prioritization was required.

CONCLUSIONS

Participatory design is often cited in the development of digital mental health resources; however, methods are diverse and often lack detailed descriptions. This study reports the outcomes and strategies used to determine priorities in the second phase of the development of the AIMhi-Y app. We provide an example and the key learnings to inform others seeking to use participatory design with a similar cohort.
Gambaran Keberdayaan Perempuan di Desa Wisata Pentingsari berdasarkan Resident Empowerment through Tourism Scale (RETS)
Authors: Rahayu Aristya Tri
Published: March 2021

The main focus of this research is to measure whether female residents in Desa Wisata Pentingsari perceive themselves as being empowered by tourism. The measurement is carried out using the concept of Resident Empowerment through Tourism Scale (RETS), formulated by Boley and McGehee (2014). This study will show the mean score on the dimensions of psychological empowerment, social empowerment, and political empowerment. Furthermore, the mean score will be interpreted with a scale of assessment proposed by Umar (1998). A questionnaire was distributed to 100 women in Pentingsari Tourism Village who are at productive age between 15 - 64 years old. The result shows that the women in Pentingsari Tourism Village perceived themselves to be more psychologically empowered than socially or politically. On the psychological empowerment, the mean score shows a very high score of 4.26. Meanwhile, on the dimension of social empowerment, the mean score shows a high category of 4.19 and on the dimension of political empowerment 3.69, still in the category high score.
Tingkat Pemahaman Masyarakat Lokal sebagai Pemangku Kepentingan Kunci di Tebing Breksi Yogyakarta Terhadap Prinsip-Prinsip Pariwisata Berkelanjutan Berdasarkan SUSTDI
Authors: Ayuningtyas Tania Nugraheni
Published: March 2021

Tourism has involved the local communities as a key stakeholders in many tourism destination in Indonesia that are growing due to the phenomenon of digital tourism. In Tebing Breksi Yogyakarta, the growth of tourism sector as a result of the digital tourism phenomenon has made the local people relying on tourism as the main sector to ful l economic needs after the mining ban from the local government. This research conduct the SUSTDI (Stakeholder Understanding of Sustainable Tourism Development Index) method as a tool to asses level of understanding of local communities about sustainable tourism concepts. According to Timur & Getz (2009: 223) about the theory of key stakeholder role, three groups of local community has identi ed such as: host community group, local authority group and tourism industry group. The proportional sampling and strati ed random sampling conducted to determined the amount of representative respondent. The result showed that the local communities as the key stakeholder in Tebing Breksi have a high overall level of understanding about the sustainable tourism concept at the scale 4,19 out of 5,00. Despite of that, the level of understanding on the three of the group respondent on question number 23 implies that the “economic development funds should to be used to promote tourism” as “Medium”. Moreover, tourism planner can use this results to develop a precise education and training program to improve their knowledge about sustainable tourism development.