bluuebunny/crossref_metadata_2025 huggingface dataset:
Marked T cell activation, senescence, exhaustion and skewing towards TH17 in patients with Covid-19 pneumonia
Authors: De Biasi Sara , Meschiari Marianna , Gibellini Lara , Bellinazzi Caterina , Borella Rebecca , Fidanza Lucia , Tartaro Domenico Lo , Mattioli Marco , Paolini Annamaria , Menozzi Marianna , Milić Jovana , Franceschi Giacomo , Fantini Riccardo , Tonelli Roberto , Sita Marco , Sarti Mario , Clini Enrico , Girardis Massimo , Guaraldi Giovanni , Mussini Cristina , Cossarizza Andrea
Published: April 2020

We have deeply investigated T cell compartment, plasma cytokines and cells producing cytokines in patients affected by Covid-19. At admission, patients were lymphopenic; in all of them SARS-CoV-2 was detected in a nasopharyngeal swab specimen by real-time RT-PCR, and pneumonia was subsequently confirmed by X-rays.Detailed 18-parameter flow cytometry was performed in 21 patients and 13 controls. Coupling polychromatic cytometry with unsupervised data analysis, we found that patients show an increased amount of CD4+ T lymphocytes that were activated, exhausted, stem memory or Treg. Similar results concerning activation and exhaustion were found in the CD8+ T cell compartment, within which the differences were even greater.Measuring plasma level of 31 cytokines linked to inflammation revealed that Covid-19 showed a dramatic increase of several molecules, such as TH1 and TH2 cytokines, chemokines, galectins, pro- and anti-inflammatory mediators, confirming the importance of a massive immune activation causing the cytokine storm. Then, intracellular staining detecting the simultaneous production of different cytokines after a para-physiologic stimulus given by anti-CD3/CD28 mAbs revealed not only a high capacity to produce a variety of molecules, including TNF-a, IFN-g and IL-2, but also a significant skewing of CD4+ T cells towards the TH17 phenotype.A therapeutic approach now exists based on the administration of drugs that block IL-6 pathway, and is now consistently improving the course of the disease. IL-17 is crucial in recruiting and activating neutrophils, cells that can migrate to the lung and are heavily involved in the pathogenesis of Covid-19. We show here that a significant skewing of activated T cells towards TH17 functional phenotype exists in Covid-19 patients. Thus, we suggest that blocking IL-17 pathway by already available biological drugs that are used to treat different pathologies could be a novel, additional strategy to improve the health of patients infected by SARS-CoV-2.
Monaldijeva klasifikacija glazbe u osmom poglavlju djela Irena, iliti o ljepoti (1599.)
Authors: Jurić Janjik Monika
Published: April 2020

Dubrovački renesansni filozof i pjesnik Miho Monaldi (1540. – 1592.) u svojoj je estetičkoj raspravi Irena, iliti o ljepoti (Irene, overo della belleza, Venecija, 1599.) glazbenoj problematici posvetio čitavo poglavlje – Dialogo ottavo (fol. 135–153) – da bi predstavio svojevrsnu opću teoriju glazbene umjetnosti. U tom se poglavlju Monaldi detaljno bavio pojedinim aspektima glazbe, a to su: podjela glazbe na različite vrste, intervali, značenje u glazbi, funkcije glazbe, modusi, glazbala, odnos između glazbe i politike, odnos između glazbe i drugih »predmeta sluha« te kriteriji za postizanje »ispravne glazbe«. Radi se, dakle, o prilično velikom broju tema vezanih uz glazbenu problematiku, zbog čega se to Monaldijevo djelo smatra najznačajnijim doprinosom refleksiji o glazbi na hrvatskom području u renesansnome razdoblju. U svojoj klasifikaciji glazbe Monaldi je prednost dao vokalnoj glazbi (u odnosu na instrumentalnu), što je u potpunome skladu s općim renesansnim poimanjem glazbe.
Martin Heidegger o slikarstvu: Franz Marc i Paul Klee
Authors: Popović Una
Published: April 2020

U ovom se radu razmatra Heideggerovo razumijevanje umjetnosti s obzirom na položaj slikarstva, za koje tvrdimo da ima status ravnopravan pjesništvu. Navedena teza izvedena je polazeći od Heideggerovih komentara o Kleeu, koji pokazuju da smisao slikarstva nije u prikazivanju bivstvujućeg, već u predočavanju zahvaćanja bivstvovanja. Ista se teza analizira s obzirom na kratki Heideggerov komentar Franza Marca iz ranih radova, te se zaključuje da Heideggerova osuda apstraktnog slikarstva nije određena zahtjevom za prikazivanjem nekog bivstvujućeg, odnosno objekta. Konačno, vodeći položaj pjesništva i slikarstva pokazuje se kao naznaka novog razumijevanja slike kod Heideggera, koje povratno postavlja zahtjev za revidiranjem ustaljene interpretacije Heideggerove filozofije umjetnosti.
Newton i božanske reformacije prirode
Authors: Rujević Goran
Published: April 2020

Isaac Newton na kraju svog spisa Optika poseže za pojmom »reformacije sistema« pod kojim podrazumijeva periodičnu intervenciju Boga u postojeći sistem svijeta u svrhu odr­žanja kontinuiranog postojanja prirode sklone propadanju. Oslanjajući se na Holbachovu ideju reda, u ovom radu pružamo interpretaciju Newtonovih povremeno oprečnih tvrdnji o porijeklu i značaju ove reformacije. Naglašavajući sličnosti i razlike između ljudske i božanske spoznaje sistema prirode, dolazimo do uvida da se u Newtonovoj filozofiji prirode mogu prepoznati dvije ideje uređenog sistema: jednostavno uređen mehanički sistem i svrhovito uređen dizajnirani sistem, čija je glavna karakteristika očitovanje prisustva svemoćnog i dobrog Tvorca. Ovi pojmovi pomažu u diferenciranju Newtonova razumijevanja Boga od deističkih, kartezijanskih i Leibnizovih ideja.
Bioelectrochemically-assisted nitrogen removal in osmotic membrane bioreactor
Authors: Wu You , Cai Yun , Lu Yu-Xiang , Zhang Li-Min , Yang Xiao-Li , Song Hai-Liang , Yang Yu-Li
Published: April 2020

Nitrogen removal in osmosis membrane bioreactor (OMBR) is important to its applications but remains a challenge. In this study, a bioelectrochemically-assisted (BEA) operation was integrated into the feed side of OMBRs to enhance nitrogen removal, and sodium acetate was served as a draw solute and supplementary carbon source for the growth of denitrifying bacteria due to reversed-solute. The effects of operation mode and influent ammonium (NH4+) concentration were systematically examined. Compared to a conventional OMBR, the integrated BEA-OMBR achieved higher total nitrogen removal efficiency of 98.13%, and chemical oxygen demand removal efficiency of 95.83% with the influent NH4+-N concentration of 39 mg L−1. The sequencing analyses revealed that ammonia-oxidizing bacteria (0–0.04%), nitrite-oxidizing bacteria (0–0.16%), and denitrifying bacteria (1.98–8.65%) were in abundance of the microbial community in the feed/anode side of integrated BEA-OMBR, and thus BEA operation increased the diversity of the microbial community in OMBR. Future research will focus on improving nitrogen removal from a high ammonium strength wastewater by looping anolyte effluent to the cathode. These findings have demonstrated that BEA operation can be an effective approach to improve nitrogen removal in OMBRs toward sustainable wastewater treatment.
Componentes de cambio y economía regional: El sector manufacturero en el estado de Baja California y en el municipio de Mexicali (1985-1988)
Authors: Sánchez Soler Ma. Dolores , Ortega Villa Guadalupe , Montoya Sánchez Edna E.
Published: April 2020

Este trabajo se realizó con dos propósitos: el primero es comparar los cambios manifestados en la estructura del empleo manufacturero durante el período de 1985-1988, en el municipio de Mexicali, en relación con el estado de Baja California y el país en su conjunto; para ello se hace uso de la técnica de cambio y participación (shift & share) utilizando la información de los censos económicos: El segundo, relacionado con el anterior, se refiere a la aplicación de las tres versiones de dicha técnica a fin de determinar cuál de éstas presenta mayores elementos para la descripción de los cambios observados. El trabajo muestra que la entidad presenta ventajas de localización en las actividades de manufactura de productos metálicos, maquinaria y equipos e instrumentos quirúrgicos y de precisión; mientras que en Mexicali se registran ventajas para las actividades de papel y productos de papel y productos minerales no metálicos, aun cuando no se reporta especialización.Finalmente, se concluye que el modelo síntesis, presentado por Bishop y Simpson, es el que aporta mayores elementos para la descripción.
La organización de sindicatos de jornaleros agrícolas en el valle de Mexicali, 1920-1990
Authors: Figueroa Ramírez Leticia
Published: April 2020

En este artículo se propone que la organización de sindicatos de jornaleros agrícolas en el valle de Mexicali entre 1920 y 1990, tuvo una relación directa con situaciones coyunturales y político-ideológicas, y no como producto de concentración de fuerza de trabajo o de crecimiento de la actividad agrícola. Para constatar lo anterior, el análisis se divide en tres periodos en los que se van señalando modificaciones tanto en la composición y número de la fuerza de trabajo como en relación con la tenencia de la tierra en el valle citado. Asimismo para cada uno de los periodos se realizó la búsqueda de las situaciones arriba mencionadas, que pudieron haber impulsado a los trabajadores a organizarse. Las fluctuaciones que manifiesta la organización durante el periodo que comprende el estudio se demuestran con referencias de fuentes históricas y con los registros de esas asociaciones provenientes de la Junta Local de Conciliación y Arbitraje de Mexicali
Türkiye’deki COVID-19 Enfeksiyonu: Erken Dönem İstatistikleri ve Hastalık Seyrinin İstatistiksel Olarak Modellenmesi
Authors: ERGÜL Barış , ALTİN YAVUZ Arzu , GÜNDOĞAN AŞIK Ebru , KALAY Bahadır
Published: April 2020

2019 yılı sonunda Çin de başlayan COVID-19 enfeksiyonu resmi kayıtlara
göre 10 Nisan itibariyle 185 ülkede görülen bir pandemi durumundadır.
Hastalığın resmi bir tedavisi bulunmadığından, daha önce vakaların görüldüğü
ülkelerin bilgilerinden yararlanılmaktadır. 10 Mart 2020 tarihinde Türkiye’de
ilk vaka kayıt altına alınmıştır. Önceki ülkelerdeki vaka durumunun seyriden
hareketle alınacak tedbirler ve uygulamalara karar verilmektedir. Şu ana kadar
birçok resmi kaynak veri kaydını düzenli olarak yapmaktadır. Elde edilen bu
verilerden hareketle ülkemizdeki durumun ortaya konması yapılacak çalışmalara
ışık tutacaktır. Bu çalışmada Türkiye ve 22 farklı ülke çeşitli istatistikler
bakımından karşılaştırılmıştır. Çalışmanın devamında ülkemizdeki seyrin
durumunu tahmin etmek için büyüme eğrileri ve zaman serisi analizinden
faydalanılmıştır. İlk bir aylık verilerden hareketle elde edilen tahminler
sonucunda toplam vaka sayısının ve toplam ölüm sayısının öngörülmesinde Üstel
düzleştirme (Box-Cox) yönteminin kullanılmasının uygun olacağı belirlenmiştir.
İngilizce Hazırlık Programına Devam Eden Üniversite Öğrencilerinin İngilizce Özyeterlik İnançlarının İncelenmesi
Authors: İlbeği Aydan Seher , Çeliköz Mine
Published: April 2020

Bu araştırmanın amacı İngilizce hazırlık programına devam eden üniversite öğrencilerinin İngilizce özyeterlik inanç düzeylerini ve bazı kişisel özelliklerin İngilizce özyeterlik inancında etkili olup olmadığını belirlemektir. Araştırma, nicel araştırma desenlerinden betimsel tarama desenine göre tasarlanmıştır. Araştırmanın çalışma grubunu İstanbul’da bir özel üniversitenin ve bir devlet üniversitesinin hazırlık bölümünde öğrenim gören 410 öğrenci oluşturmaktadır. Araştırmanın verileri Hancı-Yanar ve Bümen (2012) tarafından geliştirilen “İngilizce ile İlgili Özyeterlik İnancı Ölçeği” kullanılarak toplanmıştır. Veri analizinde öğrencilerin kişisel özellikleri ve İngilizce özyeterlik inancını belirlemede betimsel istatistiklerden, bazı kişisel özelliklerine göre özyeterlik düzeyleri arasında fark olup olmadığının belirlenmesinde ise t-testi ve tek yönlü varyans analizinden yararlanılmıştır. Araştırma sonucunda öğrencilerin İngilizce özyeterlik inancının orta düzeyde olduğu saptanmıştır. Öğrencilerin İngilizce özyeterlik inanç düzeyleri en yüksek okuma becerisinde ortaya çıkarken bunu sırasıyla dinleme, konuşma ve yazma becerileri takip etmiştir. Kişisel özellikler açısından öğrencilerin cinsiyeti, herhangi bir işte çalışma durumu, kaldığı ortam ve aylık harcaması İngilizce özyeterlik inancı üzerinde etkili bulunmazken; okul türü, akademik başarı, dil seviyesi ve yaşadığı yer değişkenlerinin İngilizce özyeterlik inancında etkili olduğu tespit edilmiştir.
A Review on Metal-Free Oxidative α-Cyanation and Alkynylation of N-Substituted Tetrahydroisoquinolines as a Rapid Route for the Synthesis of Isoquinoline Alkaloids
Authors: Kouznetsov Vladimir V. , Ortiz-Villamizar Marlyn C. , Méndez-Vargas Leonor Y. , Galvis Carlos E. Puerto
Published: April 2020

As a fast-growing research field in modern organic chemistry, the crossdehydrogenative
coupling (CDC) has seen considerable development in its scope of application,
uptake into industry, and understanding of its mechanism to functionalize the tetrahydroisoquinoline
(THIQ) scaffold. Among the vast number of possibilities offered by
the CDC coupling, the metal-free oxidative α-cyanation and alkynylation reactions have
emerged as powerful strategies in the synthesis of diverse and potentially bioactive
THIQs. Even though transition-metal catalyzed CDC reactions have undoubtedly made
significant progress in THIQ chemistry, general and selective protocols for the metal-free
oxidative α-cyanation and alkynylation reactions of THIQs are urgently needed. Thereby,
this critical discussion is aimed to highlight the recent progress in this field of CDC reactions
where Csp3-H bonds are activated without metal catalysts to introduce the CN and the alkynyl groups into
the THIQ core.
Evaluation of School-based Educational Intervention to Improve Knowledge and Attitude of Adolescent Girls about Puberty Health
Authors: Khodakarami Batoul , Refaei Mansoureh , Faradmal Javad , Uraki Hakime
Published: April 2020

Background:

Awareness of pubertal issues has a great influence on the ability of girls to
cope with cognitive, social and physical changes that occur during puberty.

Objective:

The aim of this study was the evaluation of a school-based educational intervention to
improve the knowledge and attitude of adolescent girls about puberty health.

Methods:

This randomized clinical trial (Registration number: IRCT 2013111715341N2) was conducted
in Hamadan during the period of 2014-2015. Four hundred forty-six (446) adolescent female
students were recruited randomly, using a multistage sampling method. Students were randomly
assigned to three (3) groups. Group 1(educating to students) and group 2(educating to mothers)
received two 90 minutes’ puberty health educational sessions by a midwife; group 3 did not receive
any intervention. Girls' knowledge and attitude about puberty health were assessed using a questionnaire
administered to each group before and after the intervention. SPSS 16 software was used
for analyzing data.

Results:

The three groups were similar in terms of demographic characteristics. There was no significant
difference in knowledge and attitude scores between the control group and two interventional
groups before the intervention. However, after the intervention, there was a significant difference
in the knowledge and attitude of the students in the two interventional groups compared with
the control group (p<0.001). The knowledge score was significantly higher in the students' group
that was taught by the midwife (p<0.001). The attitude score was significantly higher in the students'
group to whom their mothers taught (p<0.001).

Conclusion:

Mothers would better improve the attitude of adolescent girls toward puberty health if
they were properly informed and knew how to transfer this information to their daughters. It seems
the involvement of mothers in the educating process by a specialist such as a midwife will have a
much better impact on the attitude and awareness of girls about puberty health.
Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation
Authors: Vu Tran Khac , Thanh Nguyen Thi , Minh Nguyen Van , Linh Nguyen Huong , Thao Nguyen Thi Phương , Nguyen Trương Thuc Bao , Hien Doan Thi , Chinh Luu Van , Duc Ta Hong , Anh Lai Duc , Hai Pham-The
Published: April 2020

Background:

The target-based approach to drug discovery currently attracts a great deal
of interest from medicinal chemists in anticancer drug discovery and development. Histone deacetylase
(HDAC) inhibitors represent an extensive class of targeted anti-cancer agents. Among the
most explored structure moieties, hydroxybenzamides and hydroxypropenamides have been demonstrated
to have potential HDAC inhibitory effects. Several compounds of these structural classes
have been approved for clinical uses to treat different types of cancer, such as vorinostat and belinostat.

Aims:

This study aims at developing novel HDAC inhibitors bearing conjugated quinazolinone scaffolds with potential
cytotoxicity against different cancer cell lines.

Methods:

A series of novel N-hydroxyheptanamides incorporating conjugated 6-hydroxy-2 methylquinazolin-
4(3H)-ones (15a-l) was designed, synthesized and evaluated for HDAC inhibitory
potency as well as cytotoxicity against three human cancer cell lines, including HepG-2, MCF-7
and SKLu-1. Molecular simulations were finally performed to gain more insight into the structureactivity
relationships.

Results:

It was found that among novel conjugated quinazolinone-based hydroxamic acids synthesized,
compounds 15a, 15c and 15f were the most potent, both in terms of HDAC inhibition and
cytotoxicity. Especially, compound 15f displayed up to nearly 4-fold more potent than SAHA
(vorinostat) in terms of cytotoxicity against MCF-7 cell line with IC50 value of 1.86 μM, and
HDAC inhibition with IC50 value of 6.36 μM. Docking experiments on HDAC2 isozyme showed
that these compounds bound to HDAC2 with binding affinities ranging from -10.08 to -14.93
kcal/mol compared to SAHA (-15.84 kcal/mol). It was also found in this research that most of the
target compounds seemed to be more cytotoxic toward SKLu-1than MCF-7 and HepG-2.

Conclusion:

The resesrch results suggest that some hydroxamic acids could emerge for further
evaluation and the results are well served as basics for further design of more potent HDAC inhibitors
and antitumor agents.
OKUL ÖNCESİ DÖNEM ÇOCUKLARININ BENLİK KAVRAMI VE EBEVEYN TUTUMLARI ARASINDAKİ İLİŞKİNİN İNCELENMESİ
Authors: Şenol Fatma Betül , Karaca Nezahat Hamiden
Published: April 2020

Bu çalışmanın amacı, okul öncesi dönemdeki
çocukların benlik kavramları ile ebeveyn tutumları arasındaki ilişkinin
incelenmesidir. Araştırmada genel
tarama modellerinden ilişkisel tarama modeli kullanılmıştır. Araştırmanın
çalışma grubuna, 2018-2019 eğitim-öğretim yılında Afyonkarahisar İl
Merkezindeki İl Milli Eğitim Müdürlüğüne bağlı okul öncesi eğitim kurumları
arasından basit rastgele örnekleme yöntemi ile 201 okul öncesi çocuğu ve
ebeveynleri dâhil edilmiştir. Araştırmada veri
toplama amacıyla, “Genel Bilgi Formu”, Villa ve Auzmendi (1992)
tarafından geliştirilen ve Karaca ve Aral (2017) tarafından Türkçeye uyarlanan
“Çocuğun Benlik Kavramını Algılaması (Perception of Child Self-Concept-PCSC)
Ölçme Aracı” ve Karabulut Demir ve Şendil (2008) tarafından geliştirilen
“Ebeveyn Tutum Ölçeği (ETÖ) ”kullanılmıştır. Verilerin analizinde Çoklu Doğrusal Regresyon Analizi kullanılmıştır.
Araştırmanın sonuçlarına göre, benlik kavramı ölçeği puanlarında; ebeveyn tutum
ölçeği alt boyutlarından demokratik tutum alt boyutu puanlarını anlamlı ve
pozitif yönlü yordadığı, aşırı koruyucu tutum alt boyutu puanlarını anlamlı ve
negatif yönlü yordadığı görülmektedir. Diğer alt boyutların ise benlik
üzerindeki yordayıcılığının anlamlı düzeyde olmadığı saptanmıştır. Bu sonuçlara
göre ebeveyn tutumunun çocukların benlik kavramları üzerinde oldukça etkili
olduğu söylenebilir.
Новый метод исследования структуры сигналов ядерного магнитного резонанса, регистрируемых с использованием модуляционной методики
Authors: Давыдов В.В. , Мязин Н.С. , Макеев С.С. , Дудкин В.И.
Published: April 2020

Обоснована необходимость исследования структуры сигнала ядерного магнитного резонанса, регистрируемого с использованием модуляционной методики. Установлены особенности регистрации сигнала ядерного магнитного резонанса (ЯМР) с использованием модуляционной методики, зависящие от свойств конденсированной среды, находящейся как в текущем, так и в стационарном состоянии. Предложен новый метод определения вкладов сигналов поглощения и дисперсии в регистрируемый сигнал ЯМР. Представлены результаты экспериментальных исследований. Ключевые слова: ядерный магнитный резонанс, конденсированная среда, поглощение, дисперсия, амплитудный и фазовый спектр.
Комментарий к статье А.И. Григорьева и С.О. Ширяевой "Оценка интенсивности электромагнитного излучения шаровой молнии" (ЖТФ. 2019. Т. 89. Вып. 1. С. 22--26.)
Authors: Шматов М.Л.
Published: April 2020

Paper has no abstract
Objective Characterization of Activity, Sleep, and Circadian Rhythm Patterns Using a Wrist-Worn Actigraphy Sensor: Insights Into Posttraumatic Stress Disorder
Authors: Tsanas Athanasios , Woodward Elizabeth , Ehlers Anke
Published: April 2020

Background

Wearables have been gaining increasing momentum and have enormous potential to provide insights into daily life behaviors and longitudinal health monitoring. However, to date, there is still a lack of principled algorithmic framework to facilitate the analysis of actigraphy and objectively characterize day-by-day data patterns, particularly in cohorts with sleep problems.

Objective

This study aimed to propose a principled algorithmic framework for the assessment of activity, sleep, and circadian rhythm patterns in people with posttraumatic stress disorder (PTSD), a mental disorder with long-lasting distressing symptoms such as intrusive memories, avoidance behaviors, and sleep disturbance. In clinical practice, these symptoms are typically assessed using retrospective self-reports that are prone to recall bias. The aim of this study was to develop objective measures from patients’ everyday lives, which could potentially considerably enhance the understanding of symptoms, behaviors, and treatment effects.

Methods

Using a wrist-worn sensor, we recorded actigraphy, light, and temperature data over 7 consecutive days from three groups: 42 people diagnosed with PTSD, 43 traumatized controls, and 30 nontraumatized controls. The participants also completed a daily sleep diary over 7 days and the standardized Pittsburgh Sleep Quality Index questionnaire. We developed a novel approach to automatically determine sleep onset and offset, which can also capture awakenings that are crucial for assessing sleep quality. Moreover, we introduced a new intuitive methodology facilitating actigraphy exploration and characterize day-by-day data across 49 activity, sleep, and circadian rhythm patterns.

Results

We demonstrate that the new sleep detection algorithm closely matches the sleep onset and offset against the participants' sleep diaries consistently outperforming an existing open-access widely used approach. Participants with PTSD exhibited considerably more fragmented sleep patterns (as indicated by greater nocturnal activity, including awakenings) and greater intraday variability compared with traumatized and nontraumatized control groups, showing statistically significant (P<.05) and strong associations (|R|>0.3).

Conclusions

This study lays the foundation for objective assessment of activity, sleep, and circadian rhythm patterns using passively collected data from a wrist-worn sensor, facilitating large community studies to monitor longitudinally healthy and pathological cohorts under free-living conditions. These findings may be useful in clinical PTSD assessment and could inform therapy and monitoring of treatment effects.
Assessing the Credibility and Authenticity of Social Media Content for Applications in Health Communication: Scoping Review
Authors: Jenkins Eva L , Ilicic Jasmina , Barklamb Amy M , McCaffrey Tracy A
Published: April 2020

Background

Nutrition science is currently facing issues regarding the public’s perception of its credibility, with social media (SM) influencers increasingly becoming a key source for nutrition-related information with high engagement rates. Source credibility and, to an extent, authenticity have been widely studied in marketing and communications but have not yet been considered in the context of nutrition or health communication. Thus, an investigation into the factors that impact perceived source and message credibility and authenticity is of interest to inform health communication on SM.

Objective

This study aims to explore the factors that impact message and source credibility (which includes trustworthiness and expertise) or authenticity judgments on SM platforms to better inform nutrition science SM communication best practices.

Methods

A total of 6 databases across a variety of disciplines were searched in March 2019. The inclusion criteria were experimental studies, studies focusing on microblogs, studies focusing on healthy adult populations, and studies focusing on either source credibility or authenticity. Exclusion criteria were studies involving participants aged under 18 years and clinical populations, gray literature, blogs, WeChat conversations, web-based reviews, non-English papers, and studies not involving participants’ perceptions.

Results

Overall, 22 eligible papers were included, giving a total of 25 research studies. Among these studies, Facebook and Twitter were the most common SM platforms investigated. The most effective communication style differed depending on the SM platform. Factors reported to impact credibility included language used online, expertise heuristics, and bandwagon heuristics. No papers were found that assessed authenticity.

Conclusions

Credibility and authenticity are important concepts studied extensively in the marketing and communications disciplines; however, further research is required in a health context. Instagram is a less-researched platform in comparison with Facebook and Twitter.
A Mobile Health Platform for Self-Management of Pediatric Cystic Fibrosis: Qualitative Study of Adaptation to Stakeholder Needs and Integration in Clinical Settings (Preprint)
Authors: Rutland Sarah B , Bergquist Rikard Palmer , Hager Andreas , Geurs Robin , Mims Cathy , Gutierrez Hector H , Oates Gabriela R
Published: April 2020

BACKGROUND

Cystic fibrosis (CF) is an inherited chronic condition that requires extensive daily care and quarterly clinic visits with a multidisciplinary care team. The limited exchange of information outside of the quarterly clinic visits impedes optimal disease self-management, patient engagement, and shared decision making.

OBJECTIVE

The aim of this study is to adapt a mobile health (mHealth) app originally developed in Sweden to the needs of patients, families, and health care providers in a CF center in the United States and to test it as a platform for sharing patient-generated health data with the CF health care team.

METHODS

Focus groups with health care providers of patients with CF, adolescents with CF, and caregivers of children with CF were conducted to determine what modifications were necessary. Focus group data were analyzed using a thematic analysis, and emergent themes were ranked according to desirability and technical feasibility. The mHealth platform was then modified to meet the identified needs and preferences, and the flow of patient-generated health data to a secure Research Electronic Data Capture database was tested. Protocols for data management and clinical follow-up were also developed.

RESULTS

A total of 5 focus groups with 21 participants were conducted. Recommended modifications pertained to all functionalities of the mHealth platform, including tracking of symptoms, treatments, and activities of daily care; creating and organizing medication lists and setting up reminders; generating reports for the health care team; language and presentation; sharing and privacy; and settings and accounts. Overall, health care providers recommended changes to align the mHealth platform with US standards of care, people with CF and their caregivers requested more tracking functionalities, and both groups suggested the inclusion of a mental health tracker as well as more detailed response options and precise language. Beta testers of the modified platform reported issues related to translatability to US environment and various bugs.

CONCLUSIONS

This study demonstrated the importance of identifying the needs and preferences of target users and stakeholders before adopting existing mHealth solutions. All relevant perspectives, including those of clinicians, patients, and caregivers, should be thoroughly considered to meet both end users’ needs and evidence-based practice recommendations.

CLINICALTRIAL
Capturing the surge of public interest towards Hydroxychloroquine, Azithromycin and BCG vaccine during COVID-19 Pandemic (Preprint)
Authors: Syed-Abdul Shabbir , Malwade Shwetambara , Choo Sim-Mei
Published: April 2020

UNSTRUCTURED

The outbreak of COVID-19 that started in December 2019, was declared a pandemic in March 2020. Currently, there is no specific treatment recommended and healthcare providers are struggling to find appropriate treatment regimes. Medication misinformation spread through social media has caused panic situations and self-prescription leading to harmful drug effects. The situation worsened following false propaganda via social media, leading to shortage of some medications. Our study shows the frequency of search for the medications Hydroxychloroquine (HCQ), Azithromycin and Bacillus Calmette-Guérin (BCG) vaccine in Google Trends, across 6 countries. Public interests from the United States, Italy and Spain leaned towards HCQ, whereas those from Taiwan, Japan and South Korea were keen towards learning about the BCG vaccine. Our article aimed to inform the general public of the adverse drug reactions to avoid self-prescription or yield to the assumptions of leaders and unanimous social media posts. Proactive participation and preventive measures such as social distancing, use of face masks and hand sanitizers are recommended to help curb COVID-19 and other infections.
Editorial Volume 3(1), April 2020
Authors: Prasodjo Tjahjono
Published: April 2020

Jurnal Bakti Budaya, sesuai dengan misinya, selalu berupaya untuk memublikasikan artikel yang berkaitan dengan konsep, strategi, refleksi, dan hilirisasi hasil kegiatan pengabdian kepada masyarakat. Upaya ini dilakukan mengingat pentingnya saling berbagi informasi tentang permasalahan keterlibatan dan kemanfaatan perguruan tinggi bagi kehidupan bermasyarakat. Kemudian, upaya itu diharapkan dapat menghasilkan solusi yang lebih baik dalam mengembangkan dan meningkatkan fungsi kemanfaatan perguruan tinggi bagi masyarakat. Permasalahan yang mendesak saat ini, antara lain, adalah bagaimana hilirisasi kegiatan Tri Dharma Perguruan Tinggi dapat menyentuh langsung dan memenuhi kebutuhan masyarakat luas.
Challenges and Opportunities for Increasing Media Coverage of Climate Change in Kenya
Authors: Kakonge Amb. Dr. John O.
Published: April 2020

Globally, media coverage of climate change has been disappointing in both advanced and developing countries, Kenya included. This article addresses the need to educate and train African journalists so that they can report adequately on climate change and in doing so, help not only to raise awareness of climate change but also to increase understanding of the multiple aspects of the phenomenon. Although Kenya has an elaborate governance structure in support of climate change, coordination across key ministries, departments and institutions at national and county levels has been wanting. Coverage of climate change by Kenya’s main print media houses and television stations over the last decade (2010-2019) is investigated and found to be minimal. A survey of the opinions of the local media sets the parameters for a discussion of the current challenges faced in increasing media coverage of climate change. Lack of journalistic capacity, conflicting media priorities and inadequate funding to train and support journalists are major concerns. The paper concludes with a discussion on how media coverage could be improved to close the gaps in science journalism and, in particular, coverage of climate change in Kenya.
ЭВОЛЮЦИЯ ТЕХНОЛОГИЙ ПОЗИЦИОНИРОВАНИЯ В СЕТЯХ 2G–4G. ЧАСТЬ 1
Authors: Фокин Г.
Published: April 2020

В первой части исследования, посвященного эволюции технологий позиционирования в сотовых сетях подвижной радиосвязи, анализируются и систематизируются стандартизированные методы решения задачи определения местоположения абонентского терминала с использованием базовых станций сети радиодоступа и дополнительной сетевой инфраструктуры. Рассмотренные методы классифицируются по принципам соседства, трилатерации и анализа сцен, кроме того, в первом приближении оценивается сложность процедур и программно-аппаратной реализации каждого из них.
THE VEHICLE ROUTING PROBLEM WITH STOCHASTIC DEMANDS IN AN URBAN AREA – A CASE STUDY
Authors: Marković Danijel , Petrovć Goran , Ćojbašić Žarko , Stanković Aleksandar
Published: April 2020

The vehicle routing problem with stochastic demands (VRPSD) is a combinatorial optimization problem. The VRPSD looks for vehicle routes to connect all customers with a depot, so that the total distance is minimized, each customer visited once by one vehicle, every route starts and ends at a depot, and the travelled distance and capacity of each vehicle are less than or equal to the given maximum value. Contrary to the classical VRP, in the VRPSD the demand in a node is known only after a vehicle arrives at the very node. This means that the vehicle routes are designed in uncertain conditions. This paper presents a heuristic and meta-heuristic approach for solving the VRPSD and discusses the real problem of municipal waste collection in the City of Niš.
Pemarkah Kohesi dalam Rubrik Tapaleuk Harian Pos Kupang
Authors: Taopan Lisky
Published: April 2020

Penelitian ini mengkaji “Pemarkah Kohesi dalam Rubrik Tapaleuk Harian Pos Kupang” yang bertujuan mendeskripsikan jenis dan penggunaan pemarkah kohesi dalam bahasa Melayu Kupang. Wacana yang dikaji adalah wacana yang berisi kisah hidup sepasang suami-istri yang memparodikan isu-isu hangat di kota Kupang dan sekitarnya. Hasil kajian menunjukan bahwa rubrik Tapaleuk menggunakan empat aspek kohesi garamatikal, yaitu referensi, subtitusi, elipsis, dan konjungsi. Aspek referensi atau pengacuan yang ditemukan yakni referensi persona, referensi demonstratif, dan referensi komparatif. Selanjutnya, aspek subtitusi atau penggantian yang ditemukan yakni subtitusi verba dan subtitusi klausa. Kemudian, aspek elipsis atau pelesapan yang ditemukan yakni elipsis verba dan elipsis nomina. Terakhir, aspek konjungsi atau kata hubung yang ditemukan yakni konjungsi aditif, konjungsi adversatif, konjungsi temporal, konjungsi kausal. Aspek-aspek ini digunakan sebagai pemarkah kohesi gramatikal baik dalam tataran antarklausa, antarkalimat maupun antarparagraf. Selain aspek kohesi gramatikal, ditemukan pula aspek kohesi leksikal. Aspek-aspek tersebut antara lain berupa aspek repetisi, kolokasi, hiponim, meronim, antonim, dan sinonim. Setiap aspek kohesi leksikal tersebut digunakan sebagai pemarkah kohesi leksikal antarkalimat maupun antarparagraf. Penggunaan pemarkah kohesi membuat sebuah wacana menjadi kohesif dan padu.
Kata kunci: Pemarkah kohesi, bahasa Melayu Kupang
Exhaustive Crisp Parameter Modification in Quantization Table for Effective Image Compression
Authors: Siddique Ali Akber , Qadri Muhammad Tahir , Mohy-Ud-Din Zia
Published: April 2020

In recent times, transmission of information over wireless channels is increasing at an exponential rate. Internet is major source of information; it can be in the form of video or images which alone size up to 72% of the global traffic. In order to tackle such immense data, available channel may not be enough for transmission or reception, in this regard it is imperative to use efficient compressions techniques to reduce its size. Compressed image quality depends on the Quantization Table performed after spatial transformation like Discrete Cosine Transform. Size of a raw image captured by Digital Single-Lens Reflex, having all of its traits can easily exceed 20 Mega Bytes. In proposed compression algorithm, a Crisp parameter p modification step is introduced for effective compression of an image by utilizing standard Joint Picture Expert Group Quantization Table as a baseline model. After implementation of the proposed algorithm, Mean Opinion Score is obtained from the masses through an online survey and it provide the scores of 47.633 at p = 1, 62.74 at p = 8, and 83.252 at p = 16. According to Mean opinion score, best trade-off between quality and size of an image is between the values of p ranges from 11-20, this is also proved by Mean Squared Error and Peak Signal to Noise Ratio, as their ranges are 0.00038-0.000301 and 34.09-34.92 dB respectively. Compression Ratio which is from 6.49-5.76 is also acceptable for the given range.
Central α-Klotho Suppresses NPY/AgRP Neuron Activity and Regulates Metabolism in Mice
Authors: Admin Ada , Landry Taylor , Laing Brenton Thomas , Li Peixin , Bunner Wyatt , Rao Zhijian , Prete Amber , Sylvestri Julia , Huang Hu
Published: April 2020

α-Klotho is a circulating factor
with well-documented anti-aging properties; however, the central role of
α-klotho in metabolism remains largely unexplored. The current study
investigated the potential role of central α-klotho to modulate NPY/AgRP
neurons, energy balance, and glucose homeostasis. Intracerebroventricular (ICV)
administration of α-klotho suppressed food intake, improved glucose profiles,
and reduced body weight in mouse models of Type I and II diabetes. Furthermore,
central α-klotho inhibition via an anti-α-klotho antibody impaired glucose
tolerance. Ex vivo patch clamp electrophysiology and immunohistochemical
analysis revealed that α-klotho suppresses NPY/AgRP neuron activity, at least
in part, by enhancing mIPSC’s. Experiments in hypothalamic GT1-7 cells observed
α-klotho induces phosphorylation of AKTser473, ERKthr202/tyr204,
and FOXO1ser256, as well as blunts AgRP gene transcription.
Mechanistically, fibroblast growth factor 1 (FGFR1) inhibition abolished the
downstream signaling of α-klotho, negated its ability to modulate NPY/AgRP
neurons, and blunted its therapeutic effects. PI3 kinase inhibition also
abolished α-klotho’s ability to suppress food intake and improve glucose
clearance. These results indicate a prominent role of hypothalamic
α-klotho/FGFR1/PI3K signaling in the modulation of NPY/AgRP neuron activity and
maintenance of energy homeostasis, thus providing new insight into the
pathophysiology of metabolic disease.
Effect of SiC Particle Size on the Microstructural, Mechanical and Oxidation Properties of In-situ Synthesized HfB2-SiC Composites
Authors: GÜRCAN Kübra , DERİN Bora , AYAS Erhan
Published: April 2020

In-situ synthesis and densification of hafnium diboride - silicon carbide (HfB2-SiC) ceramic composites were studied by the spark plasma sintering (SPS) method using HfO2, B, and SiC as starting powders. Influence of SiC particle size (∼2 µm and ∼10 µm) on mechanical properties and oxidation resistance of in-situ composites were extensively investigated. According to the achieved results, the highest densification (∼95 % TD) was obtained with fine SiC particle reinforcement. The measured Vickers hardness and fracture toughness of the composites containing fine SiC were 14.3 GPa and 5.42 MPa.m1/2, respectively. The fracture mode changed from transgranular cleavage to a mixed-mode, and the crack deflection was believed to be the primary toughening mechanism. From oxidation test result, the composite with fine SiC particles exhibited more inhomogeneous oxide scales compared to that of coarse SiC containing composite.
Pemeliharaan Preventif Alat Elektromedik di Puskesmas Kecamatan Kebayoran Lama
Authors: Handayani Indah Nursyamsi
Published: April 2020

Kegiatan pengabdian kepada masyarakat oleh Jurusan Teknik Elektromedik Poltekkes Kemenkes Jakarta II Tahun 2019 di wilayah Puskesmas Kecamatan Kebayoran Lama bekerjasama dengan Ikatan Elektromedis Indonesia dan PT. Medcalindo, dilaksanakan dalam rangka peningkatan pengetahuan tentang kegiatan pemeliharaan rutin yang merupakan bagian dari pemeliharaan preventif kepada operator atau pengguna alat. Metode yang digunakan dalam kegiatan ini dengan metode ceramah, diskusi dan tanya jawab. Kegiatan ini dihadiri oleh 43 peserta yang terdiri dari petugas pelayanan kesehatan di wilayah Puskesmas Kecamatan Kebayoran Lama sebanyak 28 orang, Dosen dan tenaga pengajar Teknik Elektromedik sebanyak 5 orang, mahasiswa jurusan Teknik Elektromedik sebanyak 2 orang, anggota DPC IKATEMI Jakarta Selatan sebanyak 5 orang dan Perwakilan PT. Medcalindo sebanyak 3 orang.  Kegiatan PKM telah berjalan dengan baik dan memberikan manfaat berupa peningkatan pengetahuan dan pemahaman pemeliharaan alat elektromedik, manfaat lain yang diberikan yaitu kalibrasi dan pemeliharaan terhadap 25 peralatan elektromedik di wilayah Puskesmas Kecamatan Kebayoran Lama secara cuma-cuma.
Impacto do enquadre terapêutico em grupo nas necessidades de famílias de crianças com deficiência auditiva
Authors: Brazorotto Joseli Soares , Costa Karen Julião , Souza Aline Santos de , Lima Maria Clara Oliveira
Published: April 2020

Introdução: Evidências na área da (re)habilitação auditiva infantil têm indicado a potencial ação transformadora da família como um fator robusto no prognóstico do tratamento. Fundamenta-se ainda que as intervenções devam basear-se na avaliação das necessidades das famílias. Objetivo: avaliar o impacto do enquadre terapêutico de grupo na diminuição das necessidades de familiares de crianças com deficiência auditiva. Método: estudo de intervenção realizado em um serviço de saúde auditiva do SUS, durante o período de seis meses, em que um grupo de 10 famílias de crianças com deficiência auditiva na faixa etária de 1 ano e 4 meses a 5 anos e 3 meses, usuárias de AASI ou IC, responderam ao Inventário das Necessidades Familiares nos momentos pré e pós intervenção, tendo o delineamento da intervenção sido realizado a partir das necessidades evidenciadas pelo instrumento aplicado. As sessões contaram com situações de dinâmicas de grupo, simulações, treino de habilidades e rodas de conversa. Realizada a análise estatística descritiva e indutiva, além da avaliação qualitativa, que contou com um grupo focal. Resultados: destacaram-se como tópicos de maior necessidade das famílias a comunicação com a criança com deficiência auditiva, assuntos sobre a perda auditiva e dispositivos auxiliares à audição, em especial, quanto ao implante coclear. A idade dos responsáveis e a escolaridade, bem como a idade cronológica e auditiva das crianças foram consideradas na análise de diminuição das necessidades de informações pelas famílias. Conclusão: houve impacto positivo do enquadre terapêutico em grupo nas necessidades dos familiares de crianças com deficiência auditiva.
Confiabilidade de medidas faciais indiretas obtidas por uma única estereofotografia digital tridimensional em relação a medidas faciais diretas padrão, em crianças
Authors: Costa Carolina Tavares , Silva Hilton Justino da , Gomes Adriana Camargo
Published: April 2020

Jodeh DS, Rottgers SA. High-Fidelity Anthropometric Facial Measurements Can Be Obtained From a Single Stereophotograph From the Vectra H1 3-Dimensional Camera. Cleft Palate Craniofac J. 2019;1:1-7.
O PROCESSO DE IMPLANTAÇÃO DA INTELIGÊNCIA COMPETITIVA EM UMA EMPRESA DE FACILITIES SERVICES
Authors: Domenes Priscila Michel , Urdan André Torres
Published: April 2020

A inteligência competitiva é uma forma dinâmica em que as empresas buscam informações do mercado em que atuam e de seus concorrentes para um melhor posicionamento competitivo e estratégico. Esta atividade, que nem sempre é praticada formalmente dentro de uma empresa, pode ser implementada em diversas situações, como por conta de uma crise econômica financeira ou devido à drástica redução de seu faturamento, resultado da perda de clientes ou da não captação de novos. Baseado neste cenário, esta pesquisa tem o objetivo de compreender como foi o processo de implantação da inteligência competitiva em uma empresa de facilities services brasileira. Para isso, foi utilizado um estudo de caso único com três fontes de evidências, possibilitando a triangulação dos dados coletados. Como resultado, foi possível verificar as etapas deste processo, suas implicações na rotina administrativa e como novas informações e conhecimentos são utilizados nos direcionamentos da empresa.
ATITUDE E COMPORTAMENTO SUSTENTÁVEIS DE CONSUMIDORES DA TERCEIRA IDADE
Authors: Araújo Rafaela De Almeida , Medeiros Ana Paula De Oliveira , ABREU ROMERO Cláudia BUHAMRA
Published: April 2020

Este estudo tem como objetivo investigar a atitude e o comportamento sustentável de consumidores idosos. Realizou-se uma pesquisa qualitativa, descritiva. Para a coleta de dados foram realizadas 14 entrevistas semiestruturadas com idosos entre 60 a 82 anos residentes na cidade de Fortaleza-Ceará. Os resultados apontam que os idosos apresentam uma atitude ambiental positiva, eles se preocupam com a gravidade dos problemas ambientais, principalmente no fator lixo e compreendem a importância de modificar suas ações. Quanto aos comportamentos sustentáveis percebeu-se que os idosos realizam ações no ambiente doméstico, como coleta seletiva e redução no consumo de recursos não renováveis, motivados principalmente por questões econômicas, entretanto, no ato da compra, a sustentabilidade se apresenta de forma incipiente.
Características da Produção Científica Brasileira sobre Cooperativas de Crédito no período entre 2006 e 2018
Authors: Santos Ramon Rodrigues dos , Santos Joséte Florêncio dos
Published: April 2020

Este artigo buscou identificar os elementos que descrevem o perfil das publicações científicas sobre cooperativas de crédito nos principais periódicos nacionais e internacionais, realizando uma análise bibliométrica na Scopus no período de 2006 a 2018, contemplando os termos “cooperativas de crédito”, “credit cooperatives” e “credit unions”. Os principais resultados mostram que a produção científica brasileira indexada na Scopus ainda é incipiente, com 24 trabalhos publicados, cujo ano de 2017 concentrou aproximados 20,8% desta produção (5). Em maioria, os artigos são classificados na área “Negócios, Gestão e Contabilidade” e são predominantemente produzidos por autores da  UFV e  da UFMG. Em complemento, identificou-se que a rede de autores é isolada, não havendo cooperação entre os clusters.
ОТ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙ К ИННОВАЦИОННЫМ ТЕХНОЛОГИЯМ
Authors: Goluhova E.Z.
Published: April 2020

В статье рассматриваются современные аспекты антикоагулянтной терапии у женщин в период бере- менности, а именно разные варианты назначения варфарина, низкомолекулярных гепаринов и их ком- бинации. Также освещены актуальные вопросы продолжительности антитромботической терапии при разных клинических сценариях, в основу которых положены результаты исследований, опублико- ванные в 20162017 гг. Финальная часть статьи посвящена разнообразным инновациям в медицине и, в частности, в кардиологии, таким как искусственный интеллект, современные методы коррекции генома при генетических заболеваниях, 3D-принтинг и т. д.
К ЮБИЛЕЮ ОПЕРАЦИИ КОРОНАРНОГО ШУНТИРОВАНИЯ: ЕЩЕ РАЗ ОБ ЭТОЙ ИСТОРИИ, ОБ ЭМОЦИОНАЛЬНОМ ВЫГОРАНИИ И ТРУЭНТИЗМЕ
Authors: Alshibaia M.D.
Published: April 2020

Какую дату следует считать днем рождения операции аортокоронарного шунтирования (АКШ) Такой вопрос поднимает в своей недавней публикации историк медицины Дэвид Джонс. По-видимому, наиболее важным событием в истории операции АКШ было первое успешное коронарное шунтирование, выполненное Рене Фавалоро ровно 50 лет назад, в октябре 1967 г. В данной статье сделана попытка установить другие важнейшие вехи истории операции АКШ в связи с еще некоторыми проблемами так называемым синдромом эмоционального выгорания и труэнтизмом.