bluuebunny/crossref_metadata_2025 huggingface dataset:
Lack of impact of OCTN1 gene polymorphisms on clinical outcomes of gabapentinoids in Pakistani patients with neuropathic pain
Authors: Shaheen Abida , Alam Syed Mahboob , Azam Fahad , Saleem Salman Ahmad , Khan Moosa , Hasan Syed Saud , Liaquat Afrose
Published: May 2022

Background and objective

Gabapentinoids are the first-line drugs for neuropathic pain. These drugs are the substrate of organic cation transporter (OCTN1) for renal excretion and absorption across the intestinal epithelium. Gabapentinoids exhibit wide interindividual variability in daily dosage and therapeutic efficacy which makes titration regimens prolonged for optimal efficacy. The present study aimed to investigate the possible influence of the single nucleotide polymorphism (SNP) of OCTN1 on therapeutic efficacy and safety of gabapentinoids in neuropathic pain patients of the Pakistani population.

Methods

Four hundred and twenty-six patients were enrolled in the study. All participants were genotyped for OCTN1 rs1050152 and rs3792876 by PCR-RFLP method and followed up for eight weeks. The therapeutic outcomes of gabapentinoids, reduction in pain score, inadequate or complete lack of response, adverse events (AEs) in responders and discontinuation of treatment on account of AEs were recorded for all patients.

Results

There was no significant association of genotypes and alleles of both SNPs on the clinical response of gabapentinoids (P ˃ 0.05). Similarly, significant differences were not found in the reduction of pain scores and AEs among different genotypes in the responders. The present study has reported the association of OCTN1 rs1050152 and rs3792876 polymorphisms with clinical outcomes of gabapentinoids for the first time in the real-world clinical setting.

Conclusion

Our results suggest a lack of influence of OCTN1 genetic variants in the determination of clinical response to gabapentinoids in patients with neuropathic pain in the Pakistani population. These findings signify the role of renal functions in predicting the interindividual variability to therapeutic responsiveness of gabapentinoids.
Using electronic health records to streamline provider recruitment for implementation science studies
Authors: Okorie Chiamaka L. , Gatsby Elise , Schroeck Florian R. , Ould Ismail A. Aziz , Lynch Kristine E.
Published: May 2022

Background

Healthcare providers are often targeted as research participants, especially for implementation science studies evaluating provider- or system-level issues. Frequently, provider eligibility is based on both provider and patient factors. Manual chart review and self-report are common provider screening strategies but require substantial time, effort, and resources. The automated use of electronic health record (EHR) data may streamline provider identification for implementation science research. Here, we describe an approach to provider screening for a Veterans Health Administration (VHA)-funded study focused on implementing risk-aligned surveillance for bladder cancer patients.

Methods

Our goal was to identify providers at 6 pre-specified facilities who performed ≥10 surveillance cystoscopy procedures among bladder cancer patients in the 12 months prior to recruitment start on January 16, 2020, and who were currently practicing at 1 of 6 pre-specified facilities. Using VHA EHR data (using CPT, ICD10 procedure, and ICD10 diagnosis codes), we identified cystoscopy procedures performed after an initial bladder cancer diagnosis (i.e., surveillance procedures). Procedures were linked to VHA staff data to determine the provider of record, the number of cystoscopies they performed, and their current location of practice. To validate this approach, we performed a chart review of 105 procedures performed by a random sample of identified providers. The proportion of correctly identified procedures was calculated (Positive Predictive Value (PPV)), along with binomial 95% confidence intervals (CI).

Findings

We identified 1,917,856 cystoscopies performed on 703,324 patients from October 1, 1999—January 16, 2020, across the nationwide VHA. Of those procedures, 40% were done on patients who had a prior record of bladder cancer and were completed by 15,065 distinct providers. Of those, 61 performed ≥ 10 procedures and were currently practicing at 1 of the 6 facilities of interest in the 1 year prior to study recruitment. The random chart review of 7 providers found 101 of 105 procedures (PPV: 96%; 95% CI: 91% to 99%) were surveillance procedures and were performed by the selected provider on the recorded date.

Implications

These results show that EHR data can be used for accurate identification of healthcare providers as research participants when inclusion criteria consist of both patient- (temporal relationship between diagnosis and procedure) and provider-level (frequency of procedure and location of current practice) factors. As administrative codes and provider identifiers are collected in most, if not all, EHRs for billing purposes this approach can be translated from provider recruitment in VHA to other healthcare systems. Implementation studies should consider this method of screening providers.
Research on supporting mechanism of ancillary service of PV system to grid energy efficiency based on multi-time and space-time operation
Authors: Yong Cui , Shao Mingzhen , Xiaoqian Zhou , Wen Liu , Desen Ji , Ramsey Thomas Stephen
Published: May 2022

Under the background of high-energy penetration of new energy into the power grid, this paper takes the ancillary service capability of photovoltaic energy integrated into the grid as the starting point and builds a photovoltaic system reactive power service impact evaluation model on the grid energy efficiency. This is based on the multi-temporal and spatial scale operation mode, in order to study the supporting principles of photovoltaic system reactive power services on the energy efficiency of grid operation and the law of influence on system energy efficiency changes. In this way, the space for power system energy efficiency improvement and the reactive power service market value of renewable energy are explored to improve the renewable energy auxiliary services participation in the theoretical system of electric power spot market transactions. The research conclusions can provide a decision-making reference for system dynamic energy efficiency management and can assist relevant market entities to make optimal decisions in spot market transactions, and provide empirical data for improving the theory of renewable energy participation in auxiliary service market transactions.
Persistent cryoglobulinemia after antiviral treatment is associated with advanced fibrosis in chronic hepatitis C patients
Authors: Batsaikhan Batbold , Huang Ching-I. , Yeh Ming-Lun , Huang Chung-Feng , Lin Yi-Hung , Liang Po-Cheng , Hsieh Ming-Yen , Lin Yi-Ching , Huang Jee-Fu , Chuang Wan-Long , Lee Jin-Ching , Yu Ming-Lung , Kuo Hsing-Tao , Dai Chia-Yen
Published: May 2022

Background

High dosage and longer duration of antiviral treatment has been suggested to treat cryoglobulinemia patients. We aimed to investigate the efficacy of antiviral treatment in cryoglobulinemia patients and analyze the associated factors of persistent cryoglobulinemia.

Methods

Totally 148 patients after completion of anti-HCV treatment were enrolled in our study. Serum cryoglobulinemia precipitation was assessed and analyzed for the associated factors after antiviral therapy.

Results

Fifty-one (34.5%) out of 148 patients were positive for serum cryoglobulinemia after completion of antiviral therapy. In multivariate analysis, advanced fibrosis (Odds Ratio [OR]– 4.13, 95% Confidence Interval [95% CI]– 1.53–11.17, p = 0.005) and platelet counts (OR-0.98, 95% CI– 0.97–0.99, p = 0.010) were independently and significantly associated with persistent cryoglobulinemia. The factors associated with the persistent cryoglobulinemia in SVR patients were advanced fibrosis (OR-1.93, 95% CI– 1.02–3.65, p = 0.041) and platelet count (OR-0.98, 95% CI– 0.96–0.99, p = 0.041) by multivariate analysis. Multivariate logistic regression analysis showed persistent (OR-4.83, 95% CI– 1.75–13.36, p = 0.002) was significantly associated with advanced fibrosis in patients with cryoglobulinemia follow up after antiviral therapy.

Conclusions

The prevalence of the persistent cryoglobulinemia is 34.5% after completing antiviral therapy and it is associated with advanced fibrosis, also HCV clearance.
Land-use stress alters cuticular chemical surface profile and morphology in the bumble bee Bombus lapidarius
Authors: Straub Florian , Kuppler Jonas , Fellendorf Martin , Teuscher Miriam , Vogt Juliane , Ayasse Manfred
Published: May 2022

Pollinators and other insects are currently undergoing a massive decline. Several stressors are thought to be of importance in this decline, with those having close relationships to agricultural management and practice seemingly playing key roles. In the present study, we sampled Bombus lapidarius L. workers in grasslands differing in their management intensity and management regime across three different regions along a north-south gradient in Germany. We analyzed the bees with regard to (1) their cuticular hydrocarbon profile (because of its important role in communication in social insects) and amount of scent by using gas chromatography and (2) the size of each individual by using wing distances as a proxy for body size. Our analysis revealed changes related to land-use intensity and temperature in the cuticular scent profile of bumble bees. Decreasing body size and increasing total scent amount were explained by an interaction of land-use intensity and study region, but not by land-use intensity alone. Thus, land-use intensity and temperature influence intracolonial communication and size, both of which can have strong effects on foraging. Land management and climate are therefore probably detrimental for colony maintenance and the reproductive success of bumble bees.
A topological data analysis-based method for gait signals with an application to the study of multiple sclerosis
Authors: Bois Alexandre , Tervil Brian , Moreau Albane , Vienne-Jumeau Aliénor , Ricard Damien , Oudre Laurent
Published: May 2022

In the past few years, light, affordable wearable inertial measurement units have been providing to clinicians and researchers the possibility to quantitatively study motor degeneracy by comparing gait trials from patients and/or healthy subjects. To do so, standard gait features can be used but they fail to detect subtle changes in several pathologies including multiple sclerosis. Multiple sclerosis is a demyelinating disease of the central nervous system whose symptoms include lower limb impairment, which is why gait trials are commonly used by clinicians for their patients’ follow-up. This article describes a method to compare pairs of gait signals, visualize the results and interpret them, based on topological data analysis techniques. Our method is non-parametric and requires no data other than gait signals acquired with inertial measurement units. We introduce tools from topological data analysis (sublevel sets, persistence barcodes) in a practical way to make it as accessible as possible in order to encourage its use by clinicians. We apply our method to study a cohort of patients suffering from progressive multiple sclerosis and healthy subjects. We show that it can help estimate the severity of the disease and also be used for longitudinal follow-up to detect an evolution of the disease or other phenomena such as asymmetry or outliers.
Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development
Authors: Spurgeon Megan E. , Cheng Jingwei , Ward-Shaw Ella , Dick Frederick A. , DeCaprio James A. , Lambert Paul F.
Published: May 2022

Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC). Integration of viral DNA into the human genome facilitates continued expression of the MCPyV small tumor (ST) and large tumor (LT) antigens in virus-positive MCCs. In MCC tumors, MCPyV LT is truncated in a manner that renders the virus unable to replicate yet preserves the LXCXE motif that facilitates its binding to and inactivation of the retinoblastoma tumor suppressor protein (pRb). We previously developed a MCPyV transgenic mouse model in which MCC tumor-derived ST and truncated LT expression were targeted to the stratified epithelium of the skin, causing epithelial hyperplasia, increased proliferation, and spontaneous tumorigenesis. We sought to determine if any of these phenotypes required the association between the truncated MCPyV LT and pRb. Mice were generated in which K14-driven MCPyV ST/LT were expressed in the context of a homozygous RbΔLXCXE knock-in allele that attenuates LT-pRb interactions through LT’s LXCXE motif. We found that many of the phenotypes including tumorigenesis that develop in the K14-driven MCPyV transgenic mice were dependent upon LT’s LXCXE-dependent interaction with pRb. These findings highlight the importance of the MCPyV LT-pRb interaction in an in vivo model for MCPyV-induced tumorigenesis.
Playing Nature: Ecology in Video Games, Alenda Y. Chang (2019)
Authors: Stone Kara
Published: May 2022

Review of: Playing Nature: Ecology in Video Games, Alenda Y. Chang (2019)

Minneapolis, MN: University of Minnesota Press, 320 pp.,

ISBN 978-1-51790-632-0, p/bk, $27.00
Perpaus erlatiboen balio semantikoa euskal gramatika-azterlanetan
Authors: Biguri Koldo
Published: May 2022

Euskal gramatika-lanetan perpaus erlatiboen (PE) balio semantikoaz egindako deskribapenak aztertzen ditu artikuluak. Horietan, PE esplikatibo eta espezifikatiboen arteko banaketa semantikoari baino arreta gehiago eskaini zaie erlatibo arruntaren mekanismoei, bereziki aztertu delarik zein diren errazago erlatiba daitezkeen kasuak. Aldiz, arreta txikiagoa eskaini zaio banaketa semantikoari, eta gainera bibliografian desadostasun handiak daude puntu horretan: batzuek esplikatibo eta espezifikatiboak sintaktikoki eta formalki ere bereizten direla uste duten arren, beste batzuek diote haien artean alde sintaktikorik ez dagoela, eta, beraz, erlatiboaren izenaren arabera soilik bereiz daitekeela PEen balio semantikoa. Artikuluan, deskribapen horiek azaldu eta, idazle klasiko batzuen adibideetan eta zenbait idazleren jatorrizkoak itzulpenekin erkatuz ateratako adibideetan oinarrituta, ondorioztatzen dugu azalpen horietako batzuk partzialak direla, bazterrean uzten dituztelako PE apositibo mota desberdinak eta ez dutelako kontuan hartzen erlatibakuntzak izan duen bilakaera diakronikoa eta, batez ere, XX. mende hasieratik aurrerako garbizaletasunaren eragina.
Algunos vasquismos en la correspondencia de Miguel Basterrechea (1650-1659)
Authors: Zulaika Josu M.
Published: May 2022

Los documentos antiguos escritos en castellano por vascoparlantes se constituyen en ocasiones en una importante fuente de examen y recuperación de vasquismos. Este el caso de las alrededor de 350 cartas que, entre 1650 y 1659, el aulestiarra Miguel Basterrechea escribió a su cuñado lekeitiarra José Beingolea. En dichos escritos, hemos localizado cerca de un centenar de voces vascas que constituirán el objeto del presente trabajo. Además de algún hápax, un tercio de los vasquismos que inserta Basterrechea en su correspondencia se constituyen en los primeros testimonios conocidos de estas palabras vascas.
Drought Vulnerability and Mitigation Measures in Jordan based on Spatio-temporal Assessment of Single and Composite Meteorological Drought Indices
Authors: Al Adaileh Haitham
Published: May 2022

Drought Vulnerability and Mitigation Measures in Jordan based on Spatio-temporal Assessment of Single and Composite Meteorological Drought Indices. Ph.D. Dissertation by; Haitham AlAdaileh Supervisor; Dr. Barta Károly, PhD and Prof. Dr. Rakonczai János Abstract Long monthly data (1980-2017) of rainfall, air temperature, vegetation index, and barely production data were collected and implemented to investigate drought in Jordan. Twenty-nine weather stations across the country were used as a reference for generating interpolation maps. The drought was assessed using various drought indicators; SPI, PDI, TDI, VDI, and CDI at various timescales of 12, 6, 3, and 2 months. The CDI was further used to correlate with barely production to assess the applicability for crop monitoring. Also, the CDI was implemented in groundwater vulnerability assessment in Jordan. Jordan experienced significant annual rainfall reduction trends ranging from 0.01 to 5.2 mm/year. The trend's significance and reduction rates were related to both the geographic locations and stational altitudes. Jordan highlands seem to be most affected by the reduction followed by Jordan Rift Valley and the desert region. The rainfall reduction was highly obvious at both March and November with distinct rainfall shifts at both sides of the wet season (i.e. September and May). Drought spatial and temporal assessments using 29 weather stations from 1980 till 2017 indicted that Jordan experienced periodic cycles of drought with various severity and frequency. The use of drought indicators enabled the investigation for the drought event’s characteristics. The standardized precipitation index provided a clear tool to indicate drought frequency and magnitude trends that appeared to be once every two to three years with a significant increase rate of occurrence. Although SPI12 is less effective in providing a clear understanding of the rainfall shifts and monthly reduction as compared to SPI3, however, it provides a general indication of the droughts, especially if was coupled with the Krig interpolation technique. The generated drought krig maps revealed the presence of two drought trends; local and national. With the implicitly of statistical tools as cluster analyses, three main regions of droughts were grouped in terms of severity holding similar micro-climatological conditions; northern, eastern, and southern.
The kinetics of gypsum precipitation, the inhibiting effect of citric acid and its use in the differential precipitation of Mg(OH)2 from CaSO4·2H2O
Authors: Ziegenheim Szilveszter
Published: May 2022

The crystallization of solids from supersaturated solutions is a source of numerous complications during a range of industrial processes: undesirable precipitates may clog pipelines, foul membranes, contaminate the target compounds of a process, lower the effectiveness of heat-exchange via scale formation, etc. Calcium sulfate dihydrate (CaSO4·2H2O or gypsum) is one of the most common of such solids, therefore during the last decades, numerous studies were dedicated to the investigation of the precipitation kinetics and method development potentially suitable for precipitation control and inhibition. In the experimental work leading to this dissertation, the kinetics of gypsum precipitation was studied in the entire experimentally available concentration range. The impact of citric acid (or citrate ion) on the reaction was investigated in detail including some experiments in unconventional media. The acquired experience was used to optimize the differential precipitation of magnesium hydroxide from gypsum, which provides a promising method to improve the treatments of acidic wastewaters economically and in environmentally friendly way, and could also be useful in desalination processes.
¿Qué pasa con los textos escolares?
Authors: Mizuno Haydar Jorge
Published: May 2022

Los textos escolares debe tener como objetivo principal presentar los conceptos científicos de manera que los estudiantes puedan acceder a ellos de manera sencilla puedan comprenderlos y asimilarlos de forma que sean capaces de relacionados con los hechos de su vida cotidiana. Sin embargo, el lenguaje utilizado por estos textos puede convertirse en obstáculo para el logro de este objetivo. En este artículo se presentan, brevemente, algunos de los aspectos del lenguaje de los textos de ciencias Naturales y Ciencias Sociales que, probablemente, dificultan el aprendizaje de estas asignaturas.
Group work in EFL: constructing zones of learning
Authors: Herazo Rivera José David
Published: May 2022

There seems to be agreement amongst EFL researchers that group work is one of the most important interactional contexts for promoting communication in the EFL classroom. However, the reasons underlying this accord cannot be taken for granted and still need closely scrutiny. The present study attempts to provide some arguments in favor of group work and the ways in which it may be implemented as a potentially rich zone for EFL learning. For this, the discussion has been framed by the concept of the Zone of Proximal Development (ZPD) and the way group work can generate interaction .within it. Based on this, the study includes an analysis of group work from a communicative, a cognitive, and a social-affective perspective which introduces the concepl of revoicing as a key interactional process that seems lo link these three perspectives and allows students' utterances to become mediating devices in their in-group learning process. Other concepts like inter subjectivity, frameworks of interaction, and power relations are also discussed.
La descripción en la escuela. Perspectivas y posibilidades
Authors: Ruiz Ávila Dalia
Published: May 2022

En este artículo se exhiben algunas de las recomendaciones que se hacen para la enseñanza de la descripción en diferentes materiales escolares y se propone que el tratamiento de las operaciones discursivas en la escuela se inscriba en el marco del análisis del discurso. En este desarrollo se muestra que en el ámbito escolar se le confierea la descripción un rango de esquema factible de realizarse a partir de una serie de pasos asignados; que ella no tiene valor por si misma sino sólo a partir de las relaciones que establece con la narración. En otras palabras, no se le considera una operación discursiva, y mucho menos como una competencia con funcionamientos, mecanismos y estrategias particulares que es necesario potenciar en los sujetos. De los resultados obtenidos destaca que el funcionamiento descriptivo se presenta en la práctica discursiva.
Efectos de un programa heurístico sobre el pensamiento hipotético deductivo en estudiantes de primer semestre de ingenierías
Authors: Iriarte Diazgranados Fernando , Rojas Álvarez Carlos , Carrillo Sánchez Orlando
Published: May 2022

En este artículo se presentan los resultados de un estudio que se realizó con estudiantes de primer semestre de ingenierías de la Universidad del Norte, cuyo objetivo se centró en determinar los efectos de un programa de enfoque heurístico sobre el pensamiento hipotético-deductivo de los estudiantes; para ello se utilizó un diseño cuasiexperimental, antes y después, con grupo control no equivalente. 20 Alumnos, que conformaron la muestra del grupo experimental, fueron sometidos a un programa de enfoque heurística en la asignatura de geometría durante 10 semanas de clases, con una intensidad de 3 horas semanales; mientras que 15 alumnos, que integraron la muestra del grupo control, no fueron sometidos a este programa, sino que se les impartió la asignatura de manera tradicional. El programa de enfoque heurístico se basó en la teoría cognitiva de Bruner, específicamente en los modos de representación enactiva y simbólico, y en los heurísticos del matemático Alan Schoenfeld. Se tomó como modelo de decisión estadística la distribución t de Student, con el fin de determinar si había variaciones significativas en el nivel de pensamiento hipotético-deductivo. Los resultados del estudio apoyan la hipótesis de trabajo.
Predicción de factores clave en el aumento de la demografía en Colombia a través del ensamble de modelos de Machine Learning
Authors: Ordoñez-Erazo Hugo-Armando , Ordóñez Camilo , Bucheli-Guerrero Víctor-Andrés
Published: May 2022

El envejecimiento de la población es considerado uno de los fenómenos sociales más significativos que está transformando las economías y las sociedades en todo el mundo. Según la Organización Mundial de la Salud (OMS) el envejecimiento está en aumento. En Colombia, el crecimiento demográfico presenta un incremento natural que muestra una notable diferencia entre las tasas de natalidad y las de mortalidad general. Según el DANE, en Colombia, las tasas de crecimiento natural denotan un vertiginoso declive a lo largo del tiempo. El gobierno central y los gobiernos locales pueden ayudar en la toma de decisiones para establecer políticas de salud sexual y reproductiva. Como herramienta de apoyo aparece el Machine Learning (ML), en el cual existen algoritmos que permiten crear modelos para aprender de los datos e identificar patrones que sirven para apoyar a entes gubernamentales en el proceso de toma de decisiones. Con base en lo anterior, este trabajo propone un método de ensamble de algoritmos de ML que apoye la toma de decisiones respecto al control demográfico enfocado en natalidad. El método de predicción permitió evidenciar que la disminución de nacimientos en Colombia durante los últimos años se debe al cambio en las prioridades de mujeres y hombres. Las mujeres enfrentan discriminación y dificultad en el acceso y la permanencia del empleo a causa de la maternidad. Como consecuencia, se les dificulta articular su vida profesional con el mercado laboral. Las mujeres tienen que asumir una carga desproporcionada de cuidado, por la cual quieren tener menos hijos, es decir uno o máximo dos.
Estudio taxonómico del género Cardionema (Caryophyllaceae, Paronychioideae) para la Flora Argentina
Authors: Brignone Nicolas F.
Published: May 2022

The genus Cardionema (Caryophyllaceae) is native to the New World and it comprises six species of perennial herbs, with spiny leaves and sepals, membranous stipules and bracts, and reduced petals. This study aims to update the richness, morphology and distribution of Cardionema in Argentina, based on the study of herbarium specimens. Four species of Cardionema are accepted for the Flora of Argentina; a description of each taxon, an identification key, illustrations and pictures, a comparative-morphology based table, and distribution maps are included. Two lectotypes are also designated.
Digitales Eigentraining bei Aphasie: Real-World-Data-Analyse von 797 Nutzern*innen der App »neolexon Aphasie«
Authors: Jakob H. , Pfab J. , Prams A. , Ziegler W. , Späth M.
Published: May 2022

Das Medizinprodukt »neolexon Aphasie«-App ist ein digitales Eigentraining, das von Patient*innen mit Aphasie und/oder Sprechapraxie auf dem Tablet oder PC durchgeführt wird. Trainiert werden Übungen zum Lesesinnverständnis, auditiven Sprachverständnis, schriftlichen sowie mündlichen Benennen von Wörtern, Sätzen und Texten. Eine Auswertung der Real World Data von 797 Nutzern der App sollte die Adhärenz sowie sprachliche Verbesserungen im Eigentraining näher beleuchten. Die Ergebnisse zeigen, dass die Therapiefrequenz durch ein digitales Eigentraining mit der »neolexon Aphasie«-App deutlich erhöht werden kann und dass die Korrektheit mit wiederholtem Üben der Items steigt. Schlüsselwörter: Aphasie, Sprechapraxie, App, digitales Eigentraining Abstract The medical product »neolexon Aphasia« app is a digital self-training that can be used by patients with aphasia and/or apraxia of speech on their tablet or PC. The training includes exercises for reading comprehension, auditory comprehension, written and oral naming of words, sentences and texts. Our analysis of the real-world data of 797 users of the app aims to shed light on the adherence as well as linguistic improvements in the actual training. The results show that the frequency of therapy can be significantly increased by digital self-training with the »neolexon Aphasia« app and that correctness increases with repeated practice of the items. Keywords: aphasia, apraxia of speech, app, digital self-training
Automatisierte Prognose prosodischer Störungen bei Aphasie mittels künstlicher neuronaler Netze
Authors: Haring J. , Werner C. J. , Kohlschein C. , Peitz U. D. , Schumann-Werner B. , Niehues J.
Published: May 2022

Der Aachener Aphasie Test (AAT) erfasst auch die spontansprachlichen Leistungen eines Menschen mit Aphasie. Dieser Teil ist jedoch nur manuell durch geschultes Personal auswertbar. Die vorliegende Arbeit fokussiert auf die automatisierte Bewertung einer der sechs AAT-Spontansprachskalen. Im der vorgestellten Studie wird die Möglichkeit untersucht, künstliche neuronale Netze zur automatisierten Identifikation von Auffälligkeiten der Dimension »Prosodie und Artikulation« zu implementieren und verschiedene Ansätze hierzu werden verglichen. Ziel des Studienprogramms ist es, die Durchführung des AAT durch computergestützte Methoden unter Aufrechterhaltung bestehender Qualitätsanforderungen zu automatisieren. Schlüsselwörter: Aphasie, Aachener Aphasie Test, künstliche neuronale Netze, Prosodie, Dysarthrie Abstract The Aachen Aphasia Test (AAT) also records the spontaneous speech performance of a person with aphasia. However, this part can only be evaluated manually by trained personnel. The present work focuses on the automated scoring of one of the six AAT spontaneous speech scales. The possibility of implementing artificial neural networks for the automated identification of abnormalities of the dimension »prosody and articulation« is investigated and different approaches to this are compared. The aim of the study program is to automate the performance of the AAT using computerized methods while maintaining existing quality requirements. Keywords: aphasia, Aachen Aphasia Test, artificial neural networks, prosody, dysarthria
PREDIKSI HARGA SAHAM MENGGUNAKAN GEOMETRIC BROWNIAN MOTION WITH JUMP DIFFUSION DAN ANALISIS RISIKO DENGAN EXPECTED SHORTFALL (Studi Kasus: Harga Penutupan Saham PT. Waskita Karya Persero Tbk.)
Authors: Khoir Nidaul , Maruddani Di Asih I , Ispriyanti Dwi
Published: May 2022

Investment is an activity that is quite popular among investors in recent years. One of the forms of investment in the financial sector is investing in the capital market by buying stocks in a company. The level of profit from stock investment activities can be seen from the value of stock returns. Factors that can affect the value of stock returns are stock prices. However, stock prices often experience unpredictable changes so that they experience fluctuating movements with increasing time and developing situations, therefore a stock price model is needed to predict stock prices in the future period. The Geometric Brownian Motion with Jump Diffusion’s method is more appropriate to be used in predicting stock prices if there is a jump in stock price data. Predicted stock prices can be used as a basis for measuring the value of investment risk. The results of data processing indicate that the stock return data of PT. Waskita Karya Persero Tbk has a kurtosis value > 3 which means there is a jump in stock return data so that it is more accurately modeled using the Geometric Brownian Motion with Jump Diffusion’s method. The prediction results have a good level of accuracy based on the MAPE value of 18,733%. Furthermore, in order to measure the investment risk of the predicted stock price of PT. Waskita Karya Persero Tbk used the Expected Shortfall Historical Simulation’s method with a significance level of α = 5%, the results were 0,10939, and for the significance level α = 10%, the results were 0,07596. The calculation results show that the greater the trust level used, the greater the risk borne by investors.Keywords: Jump Diffusion Process, Expected Shortfall, Risk, Extreme Value
PERHITUNGAN HARGA PREMI ASURANSI PERTANIAN KOMODITAS CABAI RAWIT BERBASIS INDEKS CURAH HUJAN DENGAN METODE BLACK-SCHOLES
Authors: Togatorop Ruth Fransiska , Maruddani Di Asih I , Tarno Tarno
Published: May 2022

Indonesia is a country with two seasons, dry season and wet season. Unstable rainfall significantly affects the production of cayenne pepper and can lead to crop failure. Agricultural insurance is insurance that plays a role in protecting farmers from lost crops. Rainfall and cayenne pepper production has a strong linear relationship. Assumptions in the Black-Scholes method such as the option used are European type options, do not provide dividends, there are no transaction costs, and the condition of the data after operation meets lognormal assumptions, supports this research in determining agricultural insurance premiums based on rainfall index using Balck-Scholes method. This research aims to determine the value of the precipitation index and the premiums to be paid using the Black-Scholes method. The Black-Scholes method is one of the methods used in determining the value of options in stock prices. The result of this study was that when rainfall is 109.10 mm, the premium must be paid by Rp 90,330.0475 and when rainfall is 153,7 mm, the premium must be paid by Rp 831.628,1900, which increased by 2,7504%. Higher rainfall results in higher premiums that must be paid.Keywords : Agricultural Insurance, Rainfall Index, Black-Scholes Method, Insurance Premium
KLASTERISASI PROVINSI DI INDONESIA BERDASARKAN FAKTOR PENYEBARAN COVID-19 MENGGUNAKAN MODEL-BASED CLUSTERING t-MULTIVARIAT
Authors: Hamidah Nor , Santoso Rukun , Rusgiyono Agus
Published: May 2022

The spread of Covid-19 had a significant impact in all sectors. Enforcement policies from the government that are appropriate with the conditions for the spread of the virus that are needed to prevent a bigger impact. Clusteritation by province based on data on the spread of Covid-19 is important for the government to set appropriate policies in order to prevent the spread of Covid-19. The data used include data on population density, testing rate, proportion of population 50 years and over, and proportion of population diligently hand-washing in each province. The data factors for the spread of Covid-19 tend to overlap and there are outliers in the data which causes the data not normally distributed. In this study, Model-Based Clustering t-multivariate was used for data clustering. The results show that using Integrated Completed Likelihood, two groups of optimal cluster were obtained. The second cluster has a higher risk of spreading Covid-19 than the first cluster. Keywords : Covid-19, Clustering, Model-Based Clustering t-Multivariat
ANALISIS SENTIMEN REVIEW APLIKASI CRYPTOCURRENCY MENGGUNAKAN ALGORITMA MAXIMUM ENTROPY DENGAN METODE PEMBOBOTAN TF, TF-IDF DAN BINARY
Authors: Tamardina Fadhilla Atansa , Yasin Hasbi , Ispriyanti Dwi
Published: May 2022

Pandemi COVID-19 yang belum berhenti menyebabkan kondisi ekonomi Indonesia kian memburuk. Masyarakat yang terkena dampak pemotongan upah akibat pandemi harus mencari cara untuk mendapatkan pendapatan pasif. Salah satu cara untuk mendapatkan hal tersebut adalah berinvestasi. Cryptocurrency adalah salah satu instrumen investasi berbasis aplikasi yang memiliki return tinggi. Aplikasi Pintu  adalah aplikasi pertama yang menyediakan fasilitas mobile apps  pada penggunanya. Aplikasi yang dirilis pada tahun 2020 ini sudah memiliki banyak ulasan yang diberikan oleh penggunanya. Ulasan ini dibutuhkan untuk mengetahui apakah ulasan yang diberikan bersifat positif atau negatif. Analisis sentimen pada aplikasi Pintu dipilih untuk melihat sentimen pengguna yang akan dibagi menjadi dua kelas sentimen yaitu positif dan negatif. Klasifikasi dilakukan dengan algoritma Maximum Entropy dengan perbandingan metode pembobotan kata Term Frequency (TF), Term Frequency-Inverse Document Frequency (TF-IDF) dan Binary. Model klasifikasi terbaik dilihat berdasarkan nilai akurasi yang dievaluasi dengan 5-Fold Cross Validation. Hasil klasifikasi model Maximum Entropy dengan Binary memiliki tingkat akurasi sebesar 83,21% sedangkan hasil klasifikasi model Maximum Entropy dengan Term Frequency hanya sebesar 83,01% dan model Maximum Entropy dengan Term Frequency-Inverse Document Frequency hanya sebesar 83,20%. Hal ini menunjukkan bahwa tidak terdapat perbedaan yang signifikan pada model algoritma Maximum Entropy dengan metode pembobotan kata Term Frequency (TF), Term Frequency-Inverse Document Frequency (TF-IDF) dan Binary. Keywords: Cryptocurrency, Binary, Term Frequency, Term Frequency-Inverse Document Frequency, Maximum Entropy
Consumo e custo energético do processo de produção de quitina para remoção de azul de metileno
Authors: Otto Iliane , Schoeler Guilherme , Vieira Mery , Quadro Maurízio , Pieniz Simone , Andreazza Robson
Published: May 2022

A quitina vem sendo obtida de resíduos de camarão para aplicação na área ambiental. No entanto, torna-se difícil estimar o consumo e custo energético do processo de produção da quitina devido à variedade de metodologias empregadas para tal finalidade. Neste sentido, este estudo selecionou duas das metodologias mais citadas, e as utilizou como referência para a obtenção de quitina através de quatro tratamentos. Nos quais realizou-se alterações nos equipamentos utilizados, e fez-se quantificações do consumo e custo energético por equipamento e processo. As quitinas obtidas foram quantificadas com relação ao rendimento do processo, e testadas como material adsorvente de corante sintético. O tratamento (T4) em que a quitina foi obtida a temperatura ambiente, com uso do Jar Test e apenas duas etapas de secagem do material merece destaque como um possível processo de obtenção de quitina. Este possibilitou um rendimento maior que 20%, e um percentual de remoção de contaminantes em torno de 60%, ao mesmo tempo que possui o menor consumo, em torno de 25 kWh, e custo energético, aproximadamente R$ 14,2, para obtenção de uma quitina com a qualidade exigida para a aplicação como descontaminante de águas, e potencial utilização na produção de quitosana, um adsorvente muito mais eficiente para a adsorção.
Análise longitudinal do desempenho do basquetebol brasileiro em 13 temporadas do Novo Basquete Brasil
Authors: Montes Canuto Sarah Cristina , Dos Reis Santos Leonardo Lucas , De Almeida Marcos Bezerra
Published: May 2022

Em 2008, o Campeonato Brasileiro Adulto Masculino de Basquetebol passou a se chamar Novo Basquete Brasil (NBB), completando 13 temporadas em junho de 2021. Esse período representa uma excelente oportunidade para se observar a evolução da modalidade com base nos indicadores estatísticos de desempenho (IED). Assim, o objetivo foi analisar longitudinalmente o desempenho agregado das equipes participantes ao longo das temporadas 2008/2009 e 2020/2021 e determinar valores de referência dos principais IED. Os IED de 3338 partidas das 13 temporadas do NBB foram coletados no site oficial do campeonato. O desempenho expresso em média ± desvio padrão dos IED básicos (ex.: arremessos, rebotes, assistências, etc.) e avançados (ex.: razão 2 pontos/3pontos – 2PT/3PT, nº de posses de bola, aproveitamento efetivo, etc.), foi comparado por ANOVA de uma entrada complementada por post hoc de Bonferroni, e os valores de referência dos IED calculados por percentis. Com o passar das temporadas, as equipes passaram a tentar mais arremessos de 3 pontos, a pontuar proporcionalmente mais via arremessos de 3 pontos e a pegar mais rebotes defensivos (valores mínimo e máximo: 20,9±5,1 e 27,8±6,3; 27,4%±9,8% e 35,6%±10,3%; 21,1±4,7 e 27,4±4,9; respectivamente; p<0,001 para todos). Por outro lado, arremessaram menos lances livres, com menor taxa de lances livres e menor razão 2PT/3PT (máximo e mínimo: 22,9±7,8 e 18,0±6,2; 28,4%±11,1% e 22,6%±9,8%; 2,1±0,9 e 1,4±0,5; respectivamente; p<0,001 para todos). Esses resultados sinalizam a execução de ações técnico-táticas mais afastadas da cesta, com arremessos de longa distância e com menor contato físico próximo ao garrafão ofensivo.
Efeito citogenotóxico do ɑ-terpineol em células meristemáticas de Allium cepa L.
Authors: Assunção Ribeiro da Costa Rafael Everton , Nunes de Melo Carlos , Reis Camboim Luiz Fernando , Grabowski Amorim Mateus , De Sousa Rodrigues Gabriela , Brandim Marques Rosemarie , Martins Francielle Alline , De Almeida Pedro Marcos
Published: May 2022

O ɑ-terpineol é uma molécula utilizada na indústria alimentícia como aromatizante e apresenta atividade antioxidante, antitumoral e antiulcerativa. O presente estudo teve como objetivo avaliar o efeito citogenotóxico do ɑ-terpineol em células meristemáticas de Allium cepa. Raízes de A. cepa foram expostas ao controle negativo (Tween 80 a 1%), solvente (água destilada) e positivo (metilmetanosulfonato, 10 µg/mL) e nas concentrações nominais do ɑ-terpineol (4,25; 8,5; 17; 34 e 68 μg/mL) por 48 e 72h. O efeito tóxico foi avaliado pelo tamanho médio de 30 raízes e a citogenotoxicidade pela quantificação do índice mitótico e alterações cromossômicas em 5.000 células de A. cepa em microscópio óptico (400x). A Análise estatística foi realizada pelo teste Tukey (p < 0,05) para avaliar a toxidade e pelo teste não paramétrico de Kruskal-Wallis (p < 0,05) na citogenotoxicidade. O ɑ-terpineol não apresentou efeito tóxico em A. cepa por 48 e 72h, mas foi citotóxico nas concentrações de 34 e 68 μg/mL por 48h e genotóxico nas maiores concentrações de 34 (72h) e 68 μg/mL (48h). A análise individual das alterações cromossômicas mostrou aumento significativo apenas de micronúcleos em 34 μg/mL por 72h de exposição. O ɑ-terpineol não foi tóxico, mas teve ação citogenotóxica nas maiores concentrações, com possibilidade de contaminação ambiental e riscos para a saúde humana e animal, uma vez que o composto é muito utilizado na indústria.
Analytical and clinical performance evaluation of a new high-sensitivity cardiac troponin I assay
Authors: Yang Shuo , Zhang Qian , Yang Boxin , Li Zijing , Sun Wenyuan , Cui Liyan
Published: May 2022

Objectives

To validate the analytical performance and diagnostic accuracy for non-ST-segment elevation myocardial infarction (NSTEMI) with a new high-sensitivity cardiac troponin I (hs-cTnI) assay on the automated light-initiated chemiluminescent assay (LiCA®) platform.

Methods

Comprehensive analytical validations were performed, and the 99th percentile upper reference limit (URL) from apparently healthy individuals were established. We evaluated the diagnostic performance of the assay for NSTEMI.

Results

The limit of quantitation (LoQ) were 1.9 ng/L (20% CV) and 5.1 ng/L (10% CV). The sex-specific 99th percentile URLs were 17.6 ng/L (4.2% CV) for men (age 20–79y) and 14.2 ng/L (4.9% CV) for women (age 19–89y) in serum, 14.4 ng/L (4.9% CV) for men (age 19–88y) and 12.9 ng/L (5.2% CV) for women (age 19–87y) in plasma, respectively. Detection rates in healthy individuals were from 98.7 to 99.1%. The correlation coefficient and median bias between LiCA and Architect were 0.985 and 0.1% (−2.0–2.9%) in full analytical range of serum specimens. In lower range (<100 ng/L), LiCA had an overall positive bias 6.7% (−1.6–13.3%), R=0.949. At the specific medical decision levels (15.2, 26.2 and 64.0 ng/L), assay difference was estimated to be <10%. No significant differences on AUC, sensitivity and specificity, NPV and PPV were found between LiCA and Architect for the diagnosis of NSTEMI.

Conclusions

LiCA hs-cTnI is a precise, highly sensitive and specific assay that meets the requirement of a 3rd generation (level 4) high-sensitivity method. The diagnostic accuracy of LiCA assay for NSTEMI is comparable to the established Architect hs-cTnI assay.
The Consumer Benchmark, Vulnerability, and the Contract Terms Transparency: A Plea for Reconsideration
Authors: Esposito Fabrizio , Grochowski Mateusz
Published: May 2022

Transparency counts amid the most typical and inherent elements of the current consumer protection toolbox in EU law. For a long time, the exact premises of this requirement have been understood in a standardized way, taking the concept of an average consumer as the benchmark. The case of 93/13/EEC Directive (UCTD) is particularly striking in this regard. The necessary connection between the average consumer and transparency comes almost without saying in both the CJEU case law, and in the scholarship provisions on the UCTD. However, Articles 4(2) and 5 of the UCTD merely refer to a consumer. The focus on the average consumer therefore reduces the scope of application suggested by the plain meaning of these provisions. The article takes a critical stance towards the communis opinio that there is a necessary connection between the average consumer and transparency in the UCTD. Relying on both legal and economic reasons, the paper supports a twofold claim: (1) The system of EU law requires, sometimes, to assess the transparency of a term from the perspective of vulnerable consumers. (2) This more demanding standard shall be used when the average consumers operating on the market do not offer herd protection to the vulnerable consumers. The article shows that the communis opinio rests on a faulty assumption, namely that vulnerable consumers are protected when core terms are transparent for the average consumer. The article shows that this is not the case under common circumstances. Demanding core terms to be transparent for the vulnerable consumer in those circumstances contributes to reaching a high level of consumer protection.
European Union Litigation
Authors: Esposito Fabrizio , Almeida Lucila de
Published: May 2022

This article provides an overview of the most relevant cases decided by the Court of Justice of the European Union concerning contract law. The present issue covers the period between the beginning of June 2021 and the end of December 2021. Out of a total of 329 judgments decided in this period, 55 had a contract law dimension.
Deutsche Hypothekenbanken zwischen Sicherheitsdenken und Spekulationsfieber: Immobilienfinanzierung im Bauboom des späten 19. Jahrhunderts
Authors: Sattler Friederike
Published: May 2022

German mortgage banks based on stock, more frequently founded from the early 1860s, used the traditional Pfandbrief system to cope with the growing tasks of urban and housing construction. Its safety for both creditors as well as debtors of real estate financing depended not least on a clear limitation of business activities. During the building boom of the late 19th century, however, many mortgage banks undertook a massive expansion of their business and developed highly complex corporate structures, so that the well-established rules for lending on real estate were increasingly undermined. Using the examples of the “Pommern-” and the “Preußenbankgruppe”, the article explores the distortions resulting from the building boom of the late 19th century and analyses the economic, penal, and legislative means that were used to solve them. The study concludes that, due to their severity, the crisis phenomena in the real estate market of the 1890s led to a uniform regulation of mortgage banks across the Reich for the first time, which indeed achieved a sustainable stabilization of the Pfandbrief system: the price, however, was the isolation of German mortgage banking from developments in Western Europe.
Gegen Immobilienspekulation und steigende Mieten?
Authors: Grotegut Anna
Published: May 2022

This article focuses on the reasons for the introduction and rapid abolition of the increment value tax on real estate in Germany between 1911 and 1913. It examines the interplay between the land reformers who campaigned for the tax and the political situation that made it possible for all parties to support an increment value tax. It highlights the fact that the tax neither fulfilled the land reform goal of combating speculation nor generated enough revenue, as was criticised. Nevertheless, the tax was exceptional because it represented the first direct financial relationship between the Empire and the municipalities. A changed political landscape made the introduction of a property tax possible, which in the eyes of many made the increment value tax redundant.