bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficient model-correction-based reliability analysis of uncertain dynamical systems
Authors: Hirzinger Benjamin , Nackenhorst Udo
Published: February 2023

The scope of this paper is to apply a model-correction-based strategy for efficient reliability analysis of uncertain dynamical systems based on a low-fidelity (LF) model whose outcomes are corrected in a probabilistic sense to represent the more realistic outcomes of a high-fidelity (HF) model. In the model-correction approach utilized, the LF model is calibrated to the HF model close to the so-called most probable point in standard normal space, which allows a more realistic assessment of the considered complex dynamical system. Since only few expensive limit state function evaluations of the HF model are required, an efficient reliability analysis is enabled. In an application example, the LF model describes an existing single-span railway bridge modelled as simply supported Euler–Bernoulli beam subjected to moving single forces representing the axle loads of a moving train. The HF modelling approach accounts for the bridge–train interaction by modelling the passing train as mass-spring-damper system, however increasing the computational effort of the limit state function evaluations. Failure probabilities evaluated with the model-correction approach are contrasted and discussed with failure probabilities of the sophisticated bridge–train interaction model evaluated with the first-order reliability method (FORM). It is demonstrated that the efficiency of the method depends on the correlation between the LF and the HF model. A comparison of the results of FORM and the model-correction-based approach shows that the latter provides reliable failure probability prediction of the HF model while leading to a significant reduction in computational effort.
Multi-period power utility optimization under stock return predictability
Authors: Bodnar Taras , Ivasiuk Dmytro , Parolya Nestor , Schmid Wolfgang
Published: February 2023

In this paper, we derive an analytical solution to the dynamic optimal portfolio choice problem in the case of an investor equipped with a power utility function of wealth. The results are established by solving the Bellman backward recursion under the assumption that the vector of asset returns follows a vector-autoregressive process with predictable variables. In an empirical study, the performance of the derived solution is compared with the one obtained by applying the numerical method. The comparison is performed in terms of the final wealth and its expected utility. It is documented that the application of the analytical solution to the multi-period portfolio choice problem leads to higher values of both the final wealth and the expected utility.
Evaluating the role of waste-to-energy and cogeneration units in district heatings and electricity markets
Authors: Allevi Elisabetta , De Giuli Maria Elena , Domínguez Ruth , Oggioni Giorgia
Published: February 2023

This paper investigates the activity of a multi-utility that uses Waste-to-Energy (WtE) and cogeneration (COG) plants to provide services in the heat and in the electricity markets. We assume that it employs WtE and COG units to participate in the day-ahead and real-time electricity markets and, with the support of heat-only units, it satisfies the heat demand of local district heating areas (DHAs). We use stochastic programming to develop three linked problems that describe the sequence of the decision process regarding the operation of WtE and COG facilities: (i) the first problem considers the point of view of the multi-utility that defines the day-ahead and the real-time heat scheduling of its plants and the maximum amount of electricity that WtE and COG units can offer in the day-ahead electricity market, taking into account the uncertainty of the real-time heat demand; (ii) the second problem models the day-ahead electricity market cleared by the Power Exchange, where the electricity dispatch of WtE and COG units is limited by the maximum power offers defined in step (i); and (iii) given the heat and power schedules respectively determined in steps (i) and (ii), the last problem describes the activity of theTransmission System Operator that re-dispatches WtE and COG outputs and decides their participation in the reserves and the real-time electricity markets, incorporating uncertain electricity demand and renewable power generation. Italian data are taken to investigate the operation of the WtE and COG plants under different assumptions. A reference analysis shows that these facilities obtain stable revenues from the heating market, but those from the electricity markets are very variable and mainly derives from reserve procurement. In addition, we perform two sensitivity analyses: in the first one, where we consider high natural gas and CO$$_2$$

2

prices, the use of WtE and COG units increases to substitute gas-fueled plants with a consequent increase of their profits; in the second one, which describes an electricity market with a high renewable penetration, the activity of these facilities becomes more irregular because of the augmented penetration of intermitted renewable generation.
Non-native Douglas fir promotes epigeal spider density, but has a mixed effect on functional diversity
Authors: Matevski Dragan , Schuldt Andreas
Published: February 2023

With climate change altering ecosystems worldwide, forest management in Europe is increasingly relying on more adaptable non-native tree species, such as Douglas fir (Pseudotsuga menziesii). However, the ecological consequences of the increased utilization of Douglas fir on arthropod diversity and ecosystem functioning are not fully known. Here we assessed how non-native Douglas fir as well as large- and small-scale differences in the environmental context, affect epigeal spider abundance, biomass, taxonomic and functional diversity, and community structure in Central European forests. Our study sites were divided into two regions with large differences in environmental conditions, with seven replicates of five stand types, including monocultures of native European beech (Fagus sylvatica), non-native Douglas fir and native Norway spruce (Picea abies), as well as two-species mixtures of European beech and each of the conifers. Contrary to our expectations, Douglas fir promoted small-scale spider diversity, and abundance and biomass (activity density). On the other hand, it decreased spider functional divergence and altered spider community structure. Microhabitat characteristics had opposing effects on spider diversity and activity density, with more open stands harboring a more diverse but less abundant spider community. Overall, our findings suggest that increasing Douglas fir utilization at the expense of Norway spruce does not necessarily decrease the diversity of epigeal arthropods and may even promote local spider diversity and activity density. However, care needs to be taken in terms of biodiversity conservation because typical forest spider species and their functional divergence were more strongly associated with native beech than with coniferous stands.
Legal reviews of in situ learning in autonomous weapons
Authors: McFarland Tim , Assaad Zena
Published: February 2023

A legal obligation to conduct weapons reviews is a means by which the international community can ensure that States assess whether the use of new types of weapons in armed conflict would raise humanitarian concerns. The use of artificial intelligence in weapon systems greatly complicates the process of conducting reviews, particularly where a weapon system is capable of continuing to ‘learn’ on its own after being deployed on the battlefield. This paper surveys current understandings of the weapons review challenges presented by in situ learning and outlines some concepts which may inform appropriate changes to existing weapons review processes. The main arguments made are that: a distinction should be drawn between learning capabilities that are limited to optimising existing behaviour and capabilities that extend to acquiring new behaviours; and the extent of a weapon system’s learning capabilities should be used as the basis for defining a schedule of weapons reviews.
Consistency of Quantum Computation and the Equivalence Principle
Authors: Nowakowski Marcin
Published: February 2023

The equivalence principle, being one of the building blocks of general relativity, seems to be crucial for analysis of quantum effects in gravity. In this paper we consider the relation between the equivalence principle and the consistency of quantum information processing in gravitational field. We propose an analysis with a looped evolution consisting of steps both in the gravitational field and in the accelerated reference frame. We show that without the equivalence principle the looped quantum evolution cannot be unitary and looses its consistency. For this reasoning the equivalence principle is formulated in terms of the gauge transformations and is analyzed for particles acquiring an appropriate phase associated with the action over the looped path. In consequence, to keep consistency of quantum operations in gravitational field, it is required to keep a quantum variant of the equivalence principle. This proves importance of the quantized version of this fundamental gravitational principle for quantum information processing.
Family firm ambidexterity: the influence of paradoxical tensions and the Entrepreneurial Family’s cohesion
Authors: Guffler Matthias , Bertschi-Michel Alexandra , Hack Andreas , Kellermanns Franz W.
Published: February 2023

This study presents paradoxical tensions as the ‘missing link’ at the intersection of the entrepreneurial family and family firm management: a link that crucially affects innovation-related decisions such as ambidexterity. Specifically, the study argues that the relationship between family cohesion and organizational ambidexterity within entrepreneurial family firms is mediated by paradoxical tensions (latent and salient). Drawing on survey data from 206 German family firms, support is found for the hypotheses advanced. Building on cognitive resource theory, this study demonstrates that differently perceived paradoxical tensions in entrepreneurial family firms have different meaningful effects on organizational ambidexterity. Implications for theory and future research are discussed.
Late-Life Changes in Ethnoracial Self-identification: Evidence from Social Security Administrative Data
Authors: Breen Casey F.
Published: February 2023

Researchers generally recognize that ethnoracial identification may shift over the life course. However, the prevalence of these shifts across cohorts and among older adults remains open questions. Using administrative data from Social Security applications from 1984 to 2007, we quantify the magnitude and direction of later-life shifts in ethnoracial self-identification between Black, White, Asian, American Indian, and Hispanic categories for the “Greatest Generation,” those born between 1901 and 1927. Overall, 2.3% of persons in these data changed their ethnoracial identification after the age of 57, with distinct patterns of change for ethnoracial subgroups. By linking to the 1940 Census, we find a positive and significant association between socioeconomic status in early life and a shift from non-White to non-Hispanic White identification in later life. We conclude that ethnoracial self-identification fluidity continues even among older adults, varying in response to social position, ethnoracial climate, and events in greater society.
Setting Health Targets Using Information from Probabilistic Projections: A Research Brief on an Application to Contraceptive Coverage
Authors: Biddlecom Ann , Sully Elizabeth A. , Kantorová Vladimíra , Wheldon Mark C. , Lince-Deroche Naomi , Riley Taylor
Published: February 2023

Broad and aspirational targets to meet health service needs are useful for advocacy, but setting measurable, time-defined targets for accelerated yet feasible progress is necessary for national monitoring and planning purposes. Information from probabilistic projections of health outcomes and service coverage can be used to set country-specific targets that reflect different starting points and rates of change. We show the utility of this approach in an application to contraceptive coverage in 131 low- and middle-income countries (LMICs) and the related cost and impact of different coverage scenarios. We use the sustainable development goal (SDG) indicator of the proportion of women who have their need for family planning satisfied with modern contraception. The results show that accelerated progress targets would collectively result in 83% of the need satisfied in 2030 for LMICs, which is 5% points higher than the projected level based on the current pace of progress. This translated into 41 million fewer women with an unmet need for modern methods and 14 million fewer unintended pregnancies. Annual direct costs would be $480 million more in 2030 to support contraceptive services compared with costs in 2030 based on the current pace of progress. As governments plan and budget for expanded health service coverage, information from probabilistic projections can guide them in setting measurable, ambitious yet realistic targets that are relevant to their particular contexts.
Vitro-derived hop (Humulus lupulus L.) leaves and roots as source of bioactive compounds: antioxidant activity and polyphenolic profile
Authors: Chiancone Benedetta , Guarrasi Valeria , Leto Leandra , Del Vecchio Lorenzo , Calani Luca , Ganino Tommaso , Galaverni Martina , Cirlini Martina
Published: February 2023

Bioactive compounds extracted from plant are of great value for those enterprises interested in the use of natural products; plant tissue culture techniques guarantee a reliable and constant biomass production. Hop (Humulus lupulus L.), with its wealth in bioactive compounds, may represent an invaluable resource. The present study focused on the characterization of vitro-derived leaves and roots of two hop plant types, Cascade and Gianni. Extracts obtained from the selected hop explants were investigated, determining their polyphenolic content as their antioxidant capacity, applying DPPH, ABTS and FRAP assays; moreover, extract molecular profile was obtained through UHPLC-MS/MS. Results confirm the wealthy in bioactive compounds and the antioxidant properties of the tested vitro-derived hop explants. The qualitative characterization of vitro-derived hop tissue extracts evidenced the presence of twenty one different compounds, already identified in open field grown hop plants, such as polyphenols, α- and β-acids, as well as xanthohumol and isoxanthohumol. The obtained outcomes lay the groundwork to further investigate the potential of vitro-derived hop plantlets as bioactive compounds source.

Graphical abstract
Naturalism, Supernaturalism, and the Question of God
Authors: Ellis Fiona
Published: February 2023

My starting point in this paper is that expansive naturalism is a defensible position. I spell out what this position involves, and grant with Iris Murdoch that we should take seriously the idea that the world in which we are immersed has an irreducibly spiritual dimension. I consider what it could mean to think of spiritual reality in supernaturalist terms, agree with the naturalist that dualistic supernaturalism is to be rejected, and ask whether one can legitimately reject this model as both a naturalist and a theist.
Eating and Body Image Disturbances in Adolescence and Substance Use Throughout Young Adulthood: Findings from the Australian Temperament Project
Authors: Linardon Jake , Greenwood Christopher J. , Macdonald Jacqui A. , Spry Elizabeth A. , Wertheim Eleanor H. , Le Grange Daniel , Letcher Primrose , Olsson Craig A.
Published: February 2023

We investigated whether eating and body image disturbances in mid-adolescence were associated with substance use in young adulthood. Participants (n = 1566) completed the drive for thinness, bulimic behavior, and body dissatisfaction subscales from the Eating Disorder Inventory during adolescence (15–16 years), and reported frequencies of substance use (tobacco, cannabis, binge drinking, other illicit substances) across young adulthood (19–20, 23–24, and 27–28 years). Adolescent body dissatisfaction was associated with a 10% increase in the rate of binge drinking and tobacco smoking, with effects being of similar magnitude in men and women, and across young adulthood. The association between bulimic behavior and tobacco smoking was strongest in the earlier years of young adulthood (19–20 years). Relationships between cannabis use, bulimic behavior, and body dissatisfaction were evident in men only. Findings highlight important targets for prevention programs, as well as focused monitoring efforts to identify individuals at risk of later substance use.
One-Year Survival of Ischemic Stroke Patients Requiring Mechanical Ventilation
Authors: Isokuortti Harri , Virta Jyri J. , Curtze Sami , Tiainen Marjaana
Published: February 2023

Background

The outcome of patients with acute ischemic stroke who require mechanical ventilation has been poor. Intubation due to a reversible condition could be associated with better 1-year survival.

Methods

All adult patients treated in Helsinki University Hospital in 2016–2020 who were admitted because of an ischemic stroke (either stroke or thrombosis seen on imaging) and needed mechanical ventilation were included in this retrospective cohort study. Data on demographics, medical history, index stroke, and indication for intubation were collected. The primary outcome was 1-year mortality. Secondary outcomes were modified Rankin Scale (mRS) score at 3 months and living arrangements at 1 year.

Results

The mean age of the cohort (N = 121) was 66 ± 11 (mean ± SD) years, and the mean admission National Institutes of Health Stroke Scale score was 17 ± 10. Forty-four (36%) patients were male. The most common indication for intubation was unconsciousness (51%), followed by respiratory failure or airway compromise (28%). One-year mortality was 55%. Three-month mRS scores were available for 114 (94%) patients, with the following distribution: 0–2, 18%; 3–5, 28%; and 6 (dead), 54%. Of the 1-year survivors, 72% were living at home. In the multivariate analysis, only age over 75 years and intubation due to unconsciousness, respiratory failure, or cardiac arrest remained significantly associated with mortality.

Conclusions

The indication for intubation seems to significantly affect outcome. Functional outcome at 3 months is often poor, but a great majority of 1-year survivors are able to live at home.
A multimodal strategy to improve race/ethnic group equity in administration of neutralizing monoclonal antibody treatment for COVID-19 outpatients
Authors: Fish Lindsey E. , Bendelow Tiffany , Gardiner Sarah , Wynia Matthew K. , Kwan Bethany M. , Hamer Mika K. , Ginde Adit A. , Hanratty Rebecca
Published: February 2023

Introduction:

Racial and ethnic minority groups have higher rates of SARS-CoV-2 infection, severe illness, and death; however, they receive monoclonal antibody (mAb) treatment at lower rates than non-Hispanic White patients. We report data from a systematic approach to improve equitable provision of COVID-19 neutralizing monoclonal antibody treatment.

Methods:

Treatment was administered at a community health urgent care clinic affiliated with a safety-net urban hospital. The approach included a stable treatment supply, a same-day test and treat model, a referral process, patient outreach, and financial support. We analyzed the race/ethnicity data descriptively and compared proportions using a chi-square test.

Results:

Over 17 months, 2524 patients received treatment. Compared to the demographics of county COVID-19-positive cases, a greater proportion of patients who received mAb treatment were Hispanic (44.7% treatment vs. 36.5% positive cases, p < 0.001), a lower proportion were White Non-Hispanic (40.7% treatment vs. 46.3% positive cases, p < 0.001), equal proportion were Black (8.2% treatment vs. 7.4% positive cases, P = 0.13), and equal proportion occurred for other race patients.

Discussion:

Implementation of multiple systematic strategies to administer COVID-19 monoclonal antibodies resulted in an equitable race/ethnic distribution of treatment.
Low rates of antibiotics prescribed during telehealth primary-care visits persisted during the coronavirus disease 2019 (COVID-19) pandemic
Authors: Jump Robin L. P. , Mongilardi Nicole , Wilson Brigid M. , Bej Taissa A. , Song Sunah , Kowal Corinne M. , Perez Federico , Akpoji Ukwen C.
Published: February 2023

For primary care clinics at a Veterans’ Affairs (VA) medical center, the shift from in-person to telehealth visits during the coronavirus disease 2019 (COVID-19) pandemic was associated with low rates of antibiotic prescription. Understanding contextual factors associated with antibiotic prescription practices during telehealth visits may help promote antibiotic stewardship in primary care settings.
The winter of raw computers: the history of the lunar and planetary reductions of the Royal Observatory, Greenwich
Authors: Belteki Daniel
Published: February 2023

In 1839 the working hours of the computers employed on the lunar and planetary reductions of the Royal Observatory, Greenwich were reduced from eleven hours to eight hours. Previous historians have explained this decrease by reference to the generally benevolent nature of the manager of the reductions, George Biddell Airy. By contrast, this article uses the letters and notes exchanged between Airy and the computers to demonstrate that the change in the working hours originated from the computers as a reaction to their poor working conditions. Through the exploration of these archival materials, the article shifts the focus of the analysis to the working experience of the computers, rather than to the administrative history of the project that inevitably tends to highlight Airy's actions. By doing so, the article shows how the computers were treated as a disposable low-skilled workforce, as opposed to aspiring astronomers with considerable mathematical talent. Through this reframing, the article takes a step towards a working history of the observatory.
Which phonological and lexical factors best influence whether a word is produced and pronounced well?
Authors: KEHOE Margaret , ABU LABAN Aya , LESPINASSE Romane
Published: February 2023

This study examines lexical and phonological factors that influence word production and pronunciation. Specifically, we investigate whether phonological production (measured by percent consonants correct) contributes to word production and pronunciation over and above the properties of the target words (e.g., word frequency, neighborhood density, and phonetic complexity). Forty French-speaking monolingual and bilingual children, aged 1;11 to 3;1, participated in a spontaneous language sample and were administered a naming and a nonword repetition task. Their parents filled out the MacArthur Communicative Developmental Inventory (MCDI) and rated their children’s pronunciation on an experimental version of the MCDI. Statistical models indicated that word frequency and the phonetic complexity of the target words influenced whether a word was produced. These factors along with neighborhood density and the children’s production capacities influenced whether a word was pronounced poorly or well. Findings indicate that parents can provide reliable information on the word pronunciation of their children.
Activities of Daily Living Needs and Support in Adult Child-Parent Dyads
Authors: Monin Joan K. , McAvay Gail , Ali Talha , Feeney Brooke C. , Marottoli Richard , Gaugler Joseph E. , Birditt Kira
Published: February 2023

Abstract: This study examined whether changes in middle-aged children’s perceptions of their parents’ activities of daily living needs (ADL needs) were associated with changes in the mutuality of support in their relationship. A group of 366 middle-aged children in Waves 1 (2008) and 2 (2013) of the Family Exchanges Study self-reported providing and receiving tangible, emotional, and informational support to and from their n = 468 parents. Increased perceived parental ADL needs were associated with increased provision of tangible and informational support to parents but not with changes in support received. Increases in perceived parental ADL needs were associated with higher incongruence for all three support types (the child providing more support than they receive).
Roughed-Up Hillsides Reveal Tree-Toppling Winds
Authors: Wilke Carolyn
Published: February 2023

Researchers are reading pockmarks in the forest floor to study the uprooting of trees in southern Indiana and estimate how fast winds howled through the forest in the past.
Tumour-educated platelets for breast cancer detection: biological and technical insights
Authors: Liefaard Marte C. , Moore Kat S. , Mulder Lennart , van den Broek Daan , Wesseling Jelle , Sonke Gabe S. , Wessels Lodewyk F. A. , Rookus Matti , Lips Esther H.
Published: February 2023

Background

Studies have shown that blood platelets contain tumour-specific mRNA profiles tumour-educated platelets (TEPs). Here, we aim to train a TEP-based breast cancer detection classifier.

Methods

Platelet mRNA was sequenced from 266 women with stage I–IV breast cancer and 212 female controls from 6 hospitals. A particle swarm optimised support vector machine (PSO-SVM) and an elastic net-based classifier (EN) were trained on 71% of the study population. Classifier performance was evaluated in the remainder (29%) of the population, followed by validation in an independent set (37 cases and 36 controls). Potential confounding was assessed in post hoc analyses.

Results

Both classifiers reached an area under the curve (AUC) of 0.85 upon internal validation. Reproducibility in the independent validation set was poor with an AUC of 0.55 and 0.54 for the PSO-SVM and EN classifier, respectively. Post hoc analyses indicated that 19% of the variance in gene expression was associated with hospital. Genes related to platelet activity were differentially expressed between hospitals.

Conclusions

We could not validate two TEP-based breast cancer classifiers in an independent validation cohort. The TEP protocol is sensitive to within-protocol variation and revision might be necessary before TEPs can be reconsidered for breast cancer detection.
The incidence, presenting clinical findings and treatment patterns of Birdshot Retinochoroiditis in a high-prevalence region: findings from Northern Ireland, England and Wales
Authors: Khalil Rana , Petrushkin Harry , Rees Angela , Westcott Mark
Published: February 2023

Background

Birdshot Retinochoroiditis (BSRC) is a rare, chronic posterior uveitis that is strongly associated with HLA-A*29.2 positivity. To date, no robust incidence studies of BSRC have been undertaken. We present the first epidemiological study of BSRC in a high-prevalence region.

Methods

In collaboration with the British Ophthalmological Surveillance Unit, all new cases of BSRC between May 2017 and June 2019 were prospectively collected. Presenting demographics, symptoms, signs and treatment modalities were collected. A follow-up questionnaire twelve months later was also sent.

Results

Thirty-seven confirmed cases meeting the reporting criteria were identified. Twenty-three cases had both baseline and follow-up data. The total population incidence of BSRC was 0.035 cases per 100,000 person-years [95% CI 0.025–0.048 cases per 100 000 people]. 97.3% were HLA-A*29 positive. The median age was 46 years, with females making up 78% of patients. There were no significant differences in the latitudinal incidence of BSRC. At presentation, floaters were the most common symptom. Optic disc swelling was the most common sign. Mean presenting visual acuity was independent of symptom duration. Combined systemic corticosteroids and immunomodulatory therapy were the most common treatments at baseline and follow-up. Intravitreal steroids were equally popular at follow-up.

Conclusions

This study provides the first nationwide estimate of the incidence of BSRC in a high-prevalence region. Cases were more common in females, with a broad range of presentation ages. No significant latitudinal effect of incidence was identified. Systemic therapy with steroids and IMT remain the most common treatments.
The effect of puppyhood and adolescent diet on the incidence of chronic enteropathy in dogs later in life
Authors: Vuori Kristiina A. , Hemida Manal , Moore Robin , Salin Siru , Rosendahl Sarah , Anturaniemi Johanna , Hielm-Björkman Anna
Published: February 2023

Diet has a key role in the homeostasis of the gut microenvironment, influencing the microbiome, the gut barrier, host immunity and gut physiology. Yet, there is little information on the role of early diet in the onset of inflammatory gastrointestinal disorders later in life, especially in dogs. Therefore, the aim of the present cross-sectional, epidemiological study with longitudinal data, was to explore associations of companion dogs’ early life diet style and food items with owner-reported chronic enteropathy (CE) incidence in later life. Food frequency questionnaire data from Finnish companion dogs was analyzed using principal component analysis and logistic regression. We found that feeding a non-processed meat-based diet and giving the dog human meal leftovers and table scraps during puppyhood (2–6 months) and adolescence (6–18 months) were protective against CE later in life. Especially raw bones and cartilage as well as leftovers and table scraps during puppyhood and adolescence, and berries during puppyhood were associated with less CE. In contrast, feeding an ultra-processed carbohydrate-based diet, namely dry dog food or “kibble” during puppyhood and adolescence, and rawhides during puppyhood were significant risk factors for CE later in life.
Design and experiment of a combined peeling machine for water chestnut
Authors: Zhang Guozhong , Chen Liming , Guo Zhou , Liu Haopeng , Dong Zhao , Liang Fang
Published: February 2023

Water chestnut is a characteristic aquatic vegetable in China, and its demand for peeling fresh fruit is increasing rapidly. Aiming at the existing problems of high labor intensity and low efficiency of manual peeling, a combined water chestnut peeling machine was designed, which used a rotary knife to remove bud and root, and a differential friction belts to remove side peel. The performance of the peeling machine was tested with water chestnut from Xiaogan, Hubei Provence. Under the conditions of 200 g feeding mass and 10 r/min rotation speed, the single factor test was carried out with cutting speed as the influencing factor and the cutting rate of bud and root as the evaluation index. The results showed that the cutting rate of fresh fruit of water chestnut bud and root were 79.04% and 83.77% respectively when the cutting speed of rotary knife was 1.2 m/s. In the differential friction belts, high and low linear velocities were taken as the influencing factors, and the side peel removal rate was used as the evaluation index. The side peel removal rate was 84.93% at the high-speed linear velocity of 2.1 m/s and the low-speed linear velocity of 1.58 m/s. The performance of the whole machine was evaluated, and the results showed that the working loss of the combined water chestnut peeling machine was 43.03% and the comprehensive peeling rate was 77.43%, which reached the design requirements. This study can provide a reference for the research and development of water chestnut peeling device.
Optimal non-pharmaceutical pandemic response strategies depend critically on time horizons and costs
Authors: Nowak Sarah A. , Nascimento de Lima Pedro , Vardavas Raffaele
Published: February 2023

The COVID-19 pandemic has called for swift action from local governments, which have instated non-pharmaceutical interventions (NPIs) to curb the spread of the disease. The swift implementation of social distancing policies has raised questions about the costs and benefits of strategies that either aim to keep cases as low as possible (suppression) or aim to reach herd immunity quickly (mitigation) to tackle the COVID-19 pandemic. While curbing COVID-19 required blunt instruments, it is unclear whether a less-transmissible and less-deadly emerging pathogen would justify the same response. This paper illuminates this question using a parsimonious transmission model by formulating the social distancing lives vs. livelihoods dilemma as a boundary value problem using calculus of variations. In this setup, society balances the costs and benefits of social distancing contingent on the costs of reducing transmission relative to the burden imposed by the disease. We consider both single-objective and multi-objective formulations of the problem. To the best of our knowledge, our approach is distinct in the sense that strategies emerge from the problem structure rather than being imposed a priori. We find that the relative time-horizon of the pandemic (i.e., the time it takes to develop effective vaccines and treatments) and the relative cost of social distancing influence the choice of the optimal policy. Unsurprisingly, we find that the appropriate policy response depends on these two factors. We discuss the conditions under which each policy archetype (suppression vs. mitigation) appears to be the most appropriate.
Flat variable liquid crystal diffractive spiral axicon enabling perfect vortex beams generation
Authors: Pereiro-García Javier , García-de-Blas Mario , Geday Morten Andreas , Quintana Xabier , Caño-García Manuel
Published: February 2023

A transparent variable diffractive spiral axicon (DSA) based on a single LC cell is presented. The manufactured DSA can be switched between 24 different configurations, 12 convergent and 12 divergent, where the output angle is varied as a function of the applied topological charge. The active area of the device is created using a direct laser writing technique in indium-tin oxide coated glass substrates. Liquid crystal is used to modulate the phase of the incoming beam generating the different DSA configurations. The DSA consists in 24 individually driven transparent spiral shaped electrodes, each introducing a specific phase retardation. In this article, the manufacture and characterization of the tunable DSA is presented and the performance of the DSA is experimentally demonstrated and compared to the corresponding simulations.
Growth-uncoupled propanediol production in a Thermoanaerobacterium thermosaccharolyticum strain engineered for high ethanol yield
Authors: Herring Christopher D. , Ajie Maulana Permana , Lynd Lee R.
Published: February 2023

Cocultures of engineered thermophilic bacteria can ferment lignocellulose without costly pretreatment or added enzymes, an ability that can be exploited for low cost biofuel production from renewable feedstocks. The hemicellulose-fermenting species Thermoanaerobacterium thermosaccharolyticum was engineered for high ethanol yield, but we found that the strains switched from growth-coupled production of ethanol to growth uncoupled production of acetate and 1,2-propanediol upon growth cessation, producing up to 6.7 g/L 1,2-propanediol from 60 g/L cellobiose. The unique capability of this species to make 1,2-propanediol from sugars was described decades ago, but the genes responsible were not identified. Here we deleted genes encoding methylglyoxal reductase, methylglyoxal synthase and glycerol dehydrogenase. Deletion of the latter two genes eliminated propanediol production. To understand how carbon flux is redirected in this species, we hypothesized that high ATP levels during growth cessation downregulate the activity of alcohol and aldehyde dehydrogenase activities. Measurements with cell free extracts show approximately twofold and tenfold inhibition of these activities by 10 mM ATP, supporting the hypothesized mechanism of metabolic redirection. This result may have implications for efforts to direct and maximize flux through alcohol dehydrogenase in other species.
Model experiment research on HPTL anchoring technology for coal-rock composite roof in deep roadway
Authors: Xie Zhengzheng , Li Yongle , Zhang Nong , He Zhe , Cao Chuang , Li Wei
Published: February 2023

Since the western region of China, which is typical of extraordinary resource endowments, has gradually emerged as the major mining zone in China, the mining of thick coal seams and roadways with coal-rock composite roof have become more and more common in this region. However, it is extremely difficult to realize safe and effective maintenance and control of such roadways due to the differences in natural endowments of coal-rock masses. With the roadway with coal-rock composite roof of Hulusu Coal Mine in western China as the engineering background, experiment research on large-scale similarity model was conducted through comprehensive measures such as the pneumatic loading system, the surrounding rock stress monitoring system, the roadway deformation monitoring system, the bolt load monitoring system, and the displacement field monitoring system in this paper. According to the results of the experiment, the control effects of the three support systems on the roadway with coal-rock composite roof were significantly different. When the single support of short anchor bolts was applied, the comparatively low initial anchor-hold failed to constrain the initial micro deformation of the roof. Consequently, wide-range fractures of the roof were triggered at a loading pressure of 0.8 MPa. In the meanwhile, the deep surrounding rocks witnessed a downward inflection point in stress, accompanied by the possibility of the collapse of the thin-layer anchorage zone at any time. As for the support combining both short anchor bolts and long anchor cables, though a reinforced effect on the bolt anchorage zone could be achieved with the help of the cables, the active reinforcement capacity of the bolt was limited. The bolt anchorage zone was the first to be damaged at a loading pressure of 0.9 MPa, which would subsequently affect the effective bearing capacity of the deep surrounding rocks. In the application of the single support of high-strength long anchor bolts, the long bolts with high pre-tightening force were able to lock multiple groups of coal-rock strata to form a thick-layer anchorage bearing structure capable of withstanding a load as high as 1.0 MPa. The crash and collapse of the coal wall eventually caused the subsidence of the roof. Based on the intense dynamic load experiment and the feedbacks of engineering application outcomes in the field, it was concluded that the high-pretension thick-layer (HPTL) anchoring technology can effectively constrain the deformation of roadways with coal-rock composite roof with favorable application outcomes.
Situational pathogen avoidance mediates the impact of social connectedness on preventive measures during the COVID-19 pandemic
Authors: Taubert Frederike , Sprengholz Philipp , Korn Lars , Eitze Sarah , Wiedermann Marc , Betsch Cornelia
Published: February 2023

During the COVID-19 pandemic, physical distancing was one of the more important behaviours for reducing the spread of the virus. The present study investigated the influence on pathogen avoidance of familiarity with other people at private gatherings. Based on the social identity model of risk taking and the theory of the behavioural immune system, we assumed that greater familiarity with others would make people feel more connected with one another and decrease situational pathogen avoidance. This could result in lower perceptions of the risk of contracting COVID-19 and fewer protective behaviours. Two experiments (n1 = 1022, n2 = 994) showed that the negative influence of greater familiarity on the perceived risk of infection and protective behaviour is explained by an increased feeling of connectedness and less feeling of situational pathogen avoidance. In an additional survey, the participants (n = 23,023) rated the quality of their past social contacts. The correlational analyses showed that the familiarity of the other person was more important in explaining variance in protective behaviours than attitudes toward those behaviours or the pandemic situation itself. Understanding the process that result in an explosive increase in infection after social gatherings can improve infection control in the future.
A study on motion reduction for suspended platforms used in gravitational wave detectors
Authors: Koehlenbeck Sina M. , Mow-Lowry Conor M. , Bergmann Gerald , Kirchoff Robin , Koch Philip , Kühn Gerrit , Lehmann Johannes , Oppermann Patrick , Wöhler Janis , Wu David S.
Published: February 2023

We report a reduction in motion for suspended seismic-isolation platforms in a gravitational wave detector prototype facility. We sense the distance between two seismic-isolation platforms with a suspension platform interferometer and the angular motion with two optical levers. Feedback control loops reduce the length changes between two platforms separated by $$11.65\,\textrm{m}$$

11.65

m

to $$10\,\mathrm {pm\,Hz}^{-1/2}$$

10

pm

Hz

-
1
/
2

at $$100\,\textrm{mHz}$$

100

mHz

, and the angular motion of each platform is reduced to $$1\,\mathrm {nrad\, Hz}^{-1/2}$$

1

nrad

Hz

-
1
/
2

at $$100\,\textrm{mHz}$$

100

mHz

. As a result, the length fluctuations in a suspended optical resonator on top of the platforms is reduced by three orders of magnitude. This result is of direct relevance to gravitational wave detectors that use similar suspended optics and seismic isolation platforms.
Random embedded calibrated statistical blind steganalysis using cross validated support vector machine and support vector machine with particle swarm optimization
Authors: Shankar Deepa D. , Azhakath Adresya Suresh
Published: February 2023

The evolvement in digital media and information technology over the past decades have purveyed the internet to be an effectual medium for the exchange of data and communication. With the advent of technology, the data has become susceptible to mismanagement and exploitation. This led to the emergence of Internet Security frameworks like Information hiding and detection. Examples of domains of Information hiding and detection are Steganography and steganalysis respectively. This work focus on addressing possible security breaches using Internet security framework like Information hiding and techniques to identify the presence of a breach. The work involves the use of Blind steganalysis technique with the concept of Machine Learning incorporated into it. The work is done using the Joint Photographic Expert Group (JPEG) format because of its wide use for transmission over the Internet. Stego (embedded) images are created for evaluation by randomly embedding a text message into the image. The concept of calibration is used to retrieve an estimate of the cover (clean) image for analysis. The embedding is done with four different steganographic schemes in both spatial and transform domain namely LSB Matching and LSB Replacement, Pixel Value Differencing and F5. After the embedding of data with random percentages, the first order, the second order, the extended Discrete Cosine Transform (DCT) and Markov features are extracted for steganalysis.The above features are a combination of interblock and intra block dependencies. They had been considered in this paper to eliminate the drawback of each one of them, if considered separately. Dimensionality reduction is applied to the features using Principal Component Analysis (PCA). Block based technique had been used in the images for better accuracy of results. The technique of machine learning is added by using classifiers to differentiate the stego image from a cover image. A comparative study had been during with the classifier names Support Vector Machine and its evolutionary counterpart using Particle Swarm Optimization. The idea of cross validation had also been used in this work for better accuracy of results. Further parameters used in the process are the four different types of sampling namely linear, shuffled, stratified and automatic and the six different kernels used in classification specifically dot, multi-quadratic, epanechnikov, radial and ANOVA to identify what combination would yield a better result.
Spiders’ digestive system as a source of trypsin inhibitors: functional activity of a member of atracotoxin structural family
Authors: Neto Oscar Bento Silva , Valladão Rodrigo , Coelho Guilherme Rabelo , Dias Renata , Pimenta Daniel Carvalho , Lopes Adriana Rios
Published: February 2023

Spiders are important predators of insects and their venoms play an essential role in prey capture. Spider venoms have several potential applications as pharmaceutical compounds and insecticides. However, transcriptomic and proteomic analyses of the digestive system (DS) of spiders show that DS is also a rich source of new peptidase inhibitor molecules. Biochemical, transcriptomic and proteomic data of crude DS extracts show the presence of molecules with peptidase inhibitor potential in the spider Nephilingis cruentata. Therefore, the aims of this work were to isolate and characterize molecules with trypsin inhibitory activity. The DS of fasting adult females was homogenized under acidic conditions and subjected to heat treatment. After that, samples were submitted to ion exchange batch and high-performance reverse-phase chromatography. The fractions with trypsin inhibitory activity were confirmed by mass spectrometry, identifying six molecules with inhibitory potential. The inhibitor NcTI (Nephilingis cruentata trypsin inhibitor) was kinetically characterized, showing a KD value of 30.25 nM ± 8.13. Analysis of the tertiary structure by molecular modeling using Alpha-Fold2 indicates that the inhibitor NcTI structurally belongs to the MIT1-like atracotoxin family. This is the first time that a serine peptidase inhibitory function is attributed to this structural family and the inhibitor reactive site residue is identified. Sequence analysis indicates that these molecules may be present in the DS of other spiders and could be associated to the inactivation of prey trypsin (serine peptidase) ingested by the spiders.
Looking at the upper facial half enlarges the range of holistic face processing
Authors: Wang Zhe , Ni Hao , Zhou Xin , Yang Xiteng , Zheng Ziyi , Sun Yu-Hao P. , Zhang Xiaohui , Jin Haiyang
Published: February 2023

Previous studies suggested that upper and lower facial halves might be involved in the human holistic face processing differently. In this study, we replicated and extended the finding above. In Experiment 1, we used the standard composite-face task to measure holistic face processing when participants made judgements on the upper and lower facial halves separately. Results showed that the composite-face effect was stronger for the upper facial half compared to the lower half. In Experiment 2, we investigated how facial information was integrated when participants focused on different features, using the perceptual field paradigm. Results showed that: (1) more “peripheral faces” were chosen when participants fixated at the eyes than when they fixated at the mouth; (2) less “peripheral faces” were chosen for inverted faces regardless of the fixated features. Findings from both experiments together indicate that more peripheral facial information were integrated when participants focused on the upper facial half, highlighting the significance of focusing on the upper facial half in face processing.