bluuebunny/crossref_metadata_2025 huggingface dataset:
A PROSPECTIVE STUDY TO ANALYZE THE SPECIFICITY OF CHLAMYDIAL HEAT SHOCK PROTEIN (CHSP60) ANTIBODIES TO DIAGNOSE TUBAL INFERTILITY
Authors: Berestoviy Vladyslav O. , Sokol Inna V. , Mahmood Ahmad A. , Ginzburg Valentyna G. , Govsieiev Dmytro O.
Published: April 2021

The aim: To investigate the utility of testing for chlamydial heat shock protein 60 (CHSP60) antibodies in the diagnosis of tubal infertility.
Materials and methods: All the collected samples were assayed for IgM and IgG antibodies to chlamydia trachomatis and chlamydial heat shock protein 60 (CHSP60) by using
immunofluorescence and enzyme-linked immunosorbent assay (ELISA) techniques, respectively.
Results: There were no substantial differences between antibodies to C. trachomatis in females with tubal infertility (67%) and non-tubal infertility (48%). However, women
with tubal infertility (45%) have more anti-CHSP60 antibodies than non-tubal infertility (9%). Antibody screening for C. trachomatis has only (63%) sensitivity and (54%)
specificity for detecting tubal infertility. On the other hand, the CHSP60 antibody testing has (44%) sensitivity and 92% specificity for diagnosing tubal infertility. A positive
microimmunofluorescence (MIF) titer was observed in 12 of 18 (67%) females with the tubal problem, 31 of 64 (48%) with non-tubal infertility (P=0.3, OR=2.2, 95% CI=0.71
to 8.01). The CHSP60 antibodies were found in 8 of 18 (45%) females with tubal problem & 6 of 64 (9%) women with non-tubal infertility, power factor alpha α P=0.004,
OR=9.3, 95% CI=2.1 to 43.2, power= 1.002 for n= 0.05). Incorporating CHSP60 and C. trachomatis antibodies testing gives an excellent positive probability proportion of 10
to diagnose C. trachomatis associated tubal infertility.
Conclusions: CHSP60 antibody testing is a more specific evaluation than antibody testing for C. trachomatis for predicting chlamydia-associated tubal infertility. Using these
tests at the first infertility examination may help the immediate diagnosis for non-interceptive tubal infertility.
SIMULTANEOUS OPERATIONS DURING UMBILICAL AND PARAUMBILICAL HERNIA REPAIR: POSSIBLE OR NECESSARY?
Authors: Boiko Valeriy V. , Parkhomenko Kyrylo Yu. , Gaft Kostyantyn L. , Feskov Oleksandr E.
Published: April 2021

The aim of the study was to determine the possibility and effectiveness of simultaneous surgical interventions in umbilical and paraumbilical hernia repair.
Material and methods: 148 case histories were analyzed concerning patients who were routinely admitted to the surgical department of the Kharkiv Regional Council’s
Municipal Non-Profit Enterprise «Regional Clinical Hospital» between 2017 and 2019, and who underwent umbilical and paraumbilical hernia repair simultaneously with
operations related to some other surgical pathology (group 1, n = 67) or in separate interventions (group 2, n = 81). All patients were routinely operated after a set of mandatory
and additional general clinical, laboratory and instrumental research conducted in accordance with the existing guidelines. The structure and results of surgical interventions
related to the underlying disease and simultaneous operations were studied.
Results: Simultaneous operations were performed for comorbid cholecystolithiasis, diaphragmatic esophageal hernia with gastroesophageal reflux, inguinal hernia, white
line hernia, benign diseases of the uterus and uterine appendages et al. The frequency of complications and recurrences of hernia in patients with simultaneous and isolated of
umbilical hernia repair did not differ significantly. The outcome of the operation mostly depended on the method of operation (postoperative complications were most often
observed in open sutures repair and were absent in laparoscopic hernia repair). Additional risk factors were weight gain and diabetes.
Conclusions: Summarizing the data obtained, it can be concluded that application of modern endovideoscopic techniques in surgery makes simultaneous surgical interventions
not only possible but also necessary in the presence of concomitant abdominal pathology that requires surgical treatment.
ASSESSMENT OF CORRELATION BETWEEN MIRNAS-21-3P AND -210-3P EXPRESSION IN MATERNAL AND UMBILICAL CORD PLASMA AND FETAL WEIGHT AT BIRTH
Authors: Shchurevska Oksana D. , Zhuk Svitlana I.
Published: April 2021

The aim: To determine the degree of correlation of mass of the fetus and the level of mir-21, mir210 in maternal blood and umbilical cord blood of the fetus in uncomplicated gestation.
Materials and methods: 60 pregnant women with a single baby pregnancy in the third trimester (37-40 weeks) were examined. They all were given a general clinical, obstetric and
the level of miRNA21-3р and miRNA210-3р were determined in the whole blood of pregnant women (before labor) and in fetal blood obtained from the umbilical artery at birth. The
level of miRNAs was determined by the TaqMan method.
Results: After examining maternal and fetal plasma samples, we were able to determine 49 samples of hsa-miR210-3p and hsa-miR21-3p from maternal plasma, 44 samples
of hsa-miR210-3p and 37 samples of hsa-miR21-3p from the cord blood, which is a satisfactory result of more than 50%. Subsequently, between the results obtained and the
birth weight of the fetus Pearson’s correlation coefficient was studied. According to the results obtained, we found no correlation between fetal mass and hsa-miR210-3p level
in maternal plasma (r-0,068674), low positive correlation of fetal mass with hsa-miR21-3p level in maternal plasma (r-0,212181 ), an average positive correlation with the level
of hsa-miR21-3p in umbilical cord blood (r- 0.363374) and a high positive correlation with hsa-miR210-3p in umbilical cord blood (r-0.528616).
Conclusions: Determination of the level of hypoxic miRNAs, in particular hsa-miR210-3p in the umbilical cord blood of the newborn may be a marker of the functional status
of the placenta, which programs the normal development of the fetus.
AGE-RELATED MORPHO-FUNCTIONAL CHANGES IN RATS’ PANCREAS UNDER HIGH-FAT DIET-INDUCED INSULIN RESISTANCE AND ITS PHARMACOLOGICAL TREATMENT
Authors: Kvitnitskaya-Ryzhova Tatiana Yu. , Kosiakova Halyna V. , Lugovskoy Sergiy P. , Mykhalskiy Sergiy A. , Klymenko Pavlo P. , Malysheva Svetlana P. , Tkachenko Oksana S.
Published: April 2021

The aim: To determine the set of structural and functional changes in pancreatic islets (PI) of obesity-induced insulin resistant (IR) rats of different age (young and old) fed with
prolonged (6 month) high-fat diet (HFD) (58% of fat) and further treatment with N-Stearoylethanolamine (NSE), a bioactive N-Acylethanolamine.
Materials and methods: Alimentary obesity-induced IR model in rats of two age groups was used to investigate the influence of age and NSE treatment on pancreas morphology
(using histological, histochemical and immunohistochemical techniques) and on several biochemical parameters associated with DM onset.
Results: The NSE administration normalized pancreas morphology which was more affected in the old IR group; the signs of inflammation, edema, fibrosis and steatosis
were somehow diminished and PI area became significantly increased. The amount of the A-F-positive insulocytes increased and TUNEL-positive – decreased. Compensatory
hyperplasia in the affected pancreas of both age was an important indicator of NSE stimulating effect.
Conclusions: Protective effects of NSE on morpho-functional state of pancreas in HFD-induced IR rats of both age are associated not only with its anti-inflammatory, anti-oxidant
and anti-dyslipidemic properties but also with activation of PI hyperplasia and β-cells compensatory mechanisms.
PECULIARITIES OF BONE MINERAL DENSITY IN WOMEN OF DIFFERENT REPRODUCTIVE AGE WITH SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Shevchuk Sergii V. , Denyshchych Liudmyla P. , Marynych Liubov I. , Kuvikova Inna P. , Kurilenko Iryna V. , Shevchuk Olena V.
Published: April 2021

The aim: To study the peculiarities of bone mineral density in the Ukrainian population of women of different reproductive age with systemic lupus erythematosus and to
evaluate its connection with traditional and specific (typical for systemic lupus erythematosus) risk factors.
Materials and methods: A total of 91 women with systemic lupus erythematosus and 29 healthy individuals were examined. Along with the clinical study of the activity and
severity of the disease, the serum levels of interleukin-6 were determined by the enzyme immunoassay. The peculiarities of bone mineral density were studied using dual-energy
X-ray absorptiometry. The presence of fractures was evaluated by the X-ray method.
Results: Patients with systemic lupus erythematosus frequently suffer from reduced bone mineral density. Reduced bone mineral density and the appearance of fragility
fractures are associated with patients’ age, disease duration, damage index, inflammatory activity, and cumulative dose of glucocorticoids.
Conclusions: Progressive reduced bone mineral density in patients with systemic lupus erythematosus occurs not only during the aging process of a woman, but is also associated
with a number of systemic lupus erythematosus – related osteoporosis risk factors.
MODERN APPROACHES TO THE FORMATION OF PROFESSIONAL COMPETENCIES OF PHARMACISTS ON ISSUES OF MEDICINES QUALITY ASSURANCE
Authors: Ubohov Serhii H. , Soloviov Serhii O. , Yurkovska Lidiia H. , Todorova Violetta I.
Published: April 2021

The aim: To analyze, summarize and substantiate modern approaches to the formation of the professional competencies of pharmacists on issues of medicine quality assurance
in Ukraine.
Materials and methods: In this study, we performed systematic review, systematic and comparative analysis, content analysis, generalization, document analysis, logical
and graphical modeling to address those issues.
Conclusions: We showed that the curriculum and program of the «Basic foundations of the functioning of quality systems in pharmacy institutions» thematic improvement
cycle for pharmacists have been substantiated and developed. The content of the program provides an opportunity to prepare pharmacists for independent work in the field of
implementation and support of effective quality systems in pharmacy institutions and hospital pharmacy services. In the context of substantiation of modern approaches to
the preparation of pharmacists in the field of medicines quality assurance, the experience and advantages of such modern forms of training of pharmacists as the use of training
bases and blended learning have been studied. The modern approaches to the formation of the professional competencies of pharmacists on issues of medicine quality assurance
in Ukraine have been analyzed, summarize and substantiated.
MODERN CONCEPT OF UNDERSTANDING THE HUMAN RIGHT TO LIFE
Authors: Dzhuska Anna V. , Kaminska Natalіa V. , Makarukha Zoryana M.
Published: April 2021

The aim: The purpose of this article is to expose the essence of the concept of the human right to life, including in the content of this right, the duty of the state to maintain
and develop general conditions for a dignified human life.
Materials and methods: The article explores the modern concept of understanding the human right to life. The article analyzes the constitutions, other regulations, as well
as the experience of different countries in the world on this issue (in particular, the countries of Western and Eastern Europe, Latin America, USA). The empirical basis of this
research consists of two judgments of the Constitutional Court of Ukraine, Resolution of the Plenum of the Supreme Court of Ukraine «On Judicial Practice in Cases of Crimes
against the Life and Health of a Person» of February 7, 2003, № 2, and judgments of the European Court of Human Rights (Case of Lambert and others v. France of 5 June 2015,
Case Hristozov and others v. Bulgaria of 13 November 2012, Case G. N. and others v. Italy of 01 December 2009) on issues related to the human right to life. The application of
methods and techniques of scientific knowledge is conditioned by a systematic approach, which enables them to consider outlined problems in the unity of their social content
and legal form. In particular, the formal-logical method, methods of analysis and synthesis, comparative-legal method, formal legal and statistical methods are used.
Conclusions: The modern approach to understanding the human right to life presupposes that it is the state’s responsibility to protect that right, to take appropriate measures
to remedy the general conditions in society that may endanger life or prevent individuals from living a dignified life.
EFFICACY AND SENSITIVITY OF PRENATAL AND POSTNATAL ULTRASOUND SCREENING OF CONGENITAL DEVELOPMENTAL ANOMALIES OF KIDNEYS IN SLOVAKIA
Authors: Dobrovanov Oleksandr Ye.
Published: April 2021

The aim: To compare the effectiveness and sensitivity of prenatal and postnatal diagnostics in the diagnosis of congenital malformations of the urinary system in the Slovak Republic.
Materials and methods: Data of postnatal sonographic screening of congenital developmental malformations of the urinary system in Slovak Republic including 2017 were
identified and updated using a questionnaire survey, 38,496 newborns were involved. Statistical data on the proportion of prenatal diagnosis for the years 1995, 2000, 2005,
2008 and 2013-2016 were provided from the National Register of Congenital Defects. The chi2-test and t-test were applied to assess the sensitivity differences.
Results: The study showed a low sensitivity of prenatal diagnosis with its maximum in 2016, reaching 32.3% and a minimum in 2005-2008 (8.0 – 8.4%). The sensitivity of
postnatal diagnostics for selected years has always been a stable indicator and reaches 99.6%.
Conclusions: Available statistical data confirm that prenatal diagnostics of congenital developmental malformations of the urinary system in the Slovak Republic is not perfect.
Our work underlines the importance, or we should rather say inevitability of postnatal ultrasound screening for congenital developmental anomalies in the kidneys.
ANXIETY AND DEPRESSIVE DISORDERS IN PATIENTS WITH ARTERIAL HYPERTENSION
Authors: Polishchuk Oleksandr Yu. , Tashchuk Viktor K. , Barchuk Natalia I. , Amelina Tetiana M. , Hrechko Svitlana I. , Trefanenko Irina V.
Published: April 2021

The aim: To study the influence of anxiety and depressive disorders on life quality of patients with arterial hypertension.
Materials and methods: 55 patients with arterial hypertension (AH) of 2nd stage were examined to reach the goal. Age diapason was 25-73 years, the middle age was
53.56+10.28. There were 58.2% (32) of women and 41.8% (23) of men among the patients.
Results: Results analysis of the investigation of patients with arterial hypertension and anxiety and depressive disorders using the Spielberger-Khanin anxiety inventory
showed moderate (30.9%) and high (69.1%) level of trait anxiety. As for the state anxiety the high level of it was confirmed in 74.6% of studied patients and moderate level
of state anxiety in 25.5% of patients. During the analysis of gender-based distribution the trait anxiety level was significantly higher in women (p<0.05). Results of PHQ-9
showed subclinical depression level (12.7%), mild (49.1%) and moderate (16.4%). Moderate manifestations of depression were found in 12.7%, severe depression in 9.1%
(5 individuals). As for the gender-based distribution, anxiety indicators were significantly higher in women (p<0.01). HADS method did not show significant difference of depression levels of gender-based distribution.
Conclusions: The majority of individuals with arterial hypertension and nonpsychotic mental disorders have a high level of trait and state anxiety. Direct correlation was found between the trait anxiety indicator and depression severity, which were defined according to HADS and PHQ-9 questionnaires. The level of anxiety and depressive episode severity were found to be reliably higher in women in gender-based distribution, that/which was accompanied by decrease in most of the life quality indicators.
FEATURES OF VIOLATIONS OF THE STATE OF THE VAGINAL ECOSYSTEM IN PREGNANT WOMEN WITH BACTERIAL VAGINOSIS
Authors: Shcherbina Iryna M. , Plakhotna Iryna Yu.
Published: April 2021

The aim: To assess the condition of the vaginal ecosystem in pregnant women with BV.
Materials and methods: The main group consisted of 60 pregnant women with BV in the II trimester. The bacterioscopic examination, of vaginal smears was carried out. DNA
diagnostics of the microbial spectrum of vaginal contents was performed. Bacteria with biofilm were visualized by fluorescence hybridization in situ.
Results: Biofilms were found in 25 women (41.65%) of the main group, the main component of which was bacteria belonging to the Gardnerella cluster at a concentration of 7.9 ± 0.13 log CFU/ g. Atopobium vagine cluster bacteria gave positive hybridization signals in more than half of the patients and amounted to 6.8 ± 0.15 lg CFU / g. In addition, Snethia spp. was determined as a part of the biofilm at a concentration of 5.8 ± 0.3 lg CFU / g.
Conclusions: Thus, the use of the proposed treatment regimen for women with vaginal dysbiosis led to the elimination of pathogenic and conditionally pathogenic microflora.
However, the effectiveness of treatment in 5 cases was lower than expected, which indicates the emergence of bacterial resistance.
STRUCTURAL AND FUCNTIONAL PARAMETERS OF THE CARDIOVASCULAR SYSTEM DURING ATRIAL FIBRILLATION IN PATIENTS AFTER STROKE
Authors: Kamyshnikova Lyudmila A. , Efremova Olga A. , Bondarenko Ekaterina V. , Obolonkova Natalya I. , Bolkhovitina Olga A. , Yusuf Maryam W.
Published: April 2021

The aim: To evaluate the structural and functional parameters of the cardiovascular system during atrial fibrillation (AF) in patients after a stroke.
Materials and methods: In the main group, we selected 28 patients with non-valvular AF who had previously suffered an ischemic stroke (IS). The comparison group (30
people) included patients with AF without a stroke, comparable in age and gender.
Results: As a result of the study, we discovered an increase in the risk of stroke with an increase in the thickness of the intima-media complex>0.9mm. The thickness of the
interventricular septum was 1.19 (1.1; 1.25) in the group of patients with IS, and in the group of patients without IS – 1.09 (1.0; 1.19) cm (p = 0.019), the thickness of the LV
posterior wall is greater in the main group 1.14 (1.05; 1.24) and 1.09 (1.01; 1.18) cm in the comparison group (p = 0.038). The myocardial mass index is 123.3 in the main group and 107.4 g/m2 in the comparison group (p = 0.41), which indicates left ventricle (LV) hypertrophy in the main group.
Conclusions: thus, during AF in stroke patients, changes in the following structural and functional parameters of the cardiovascular system were discovered: an increase in the thickness of the interventricular septum, thickness of the posterior wall of the LV, and in the thickness of the intima-media complex.
13C-METHACETIN BREATHE TEST IN EARLY DIAGNOSTICS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Sklyarova Helen E.
Published: April 2021

The aim: Of the study was to evaluate the early utility changes of the 13C methacetin breath test parameters in patients with NAFLD.
Materials and methods: There were included 50 subjects in the study, among them 35 patients had steatosis and 15 patients had steatohepatitis, including 35 (70.0%) male
subjects and 15 (30.0%) female subjects. The control group included 17 apparently healthy volunteers, among them 10 (58.8%) subjects were male and 7 (41.2%) subjects
were female.
Results: It was determined that metabolism kinetics in case of liver steatosis was significant decreased more than 30% compared to the control group (p = 0.0001) and in case of steatohepatitis that decrease was more than 65% (p = 0.00001) compared with normal values. It resulted in less cumulative dose accumulation in steatosis (p = 0.00001) and steatohepatitis (p = 0.00001). Among the reasons for the decrease in the kinetics of metabolism in steatosis, there were insufficient response of hepatocytes on 10 minutes (<10 dose/h,%) in 40% of cases and reduction of metabolism rate amplitude at 20-40 minutes following methacetin administration.
Conclusions: The results of 13C-methacetin breath test demonstrate that in patients with NAFLD there is a gradual slowing of metabolism rate in hepatocytes, which leads to a decrease in cumulative dose.
ANALYSIS OF THE VITAMIN D RECEPTOR BSMI GENE POLYMORPHISM IN CHILDREN WITH GROWTH HORMONE DEFICIENCY
Authors: Bolshova Elena V. , Ryznychuk Mariana A. , Kvacheniuk Dmitry A.
Published: April 2021

The aim: The objective of the study was to investigate the polymorphism of the vitamin D receptor (VDR) BsmI gene in children with growth hormone deficiency and the level
of their vitamin D supply.
Materials and methods: Sixteen children diagnosed with of growth hormone deficiency who were treated at the State Institution «V.P. Komisarenko Institute of Endocrinology
and Metabolism of the National Academy of Medical Sciences of Ukraine» were examined. The patient’s gender and age, the anthropometric data, the vitamin D level in the blood, the bone age, the GH level, the IGF-1 levels, the level of calcium in the blood and VDR gene polymorphism were taken into account.
Results: It was shown that in the presence of the G/A genotype, the risk of growth hormone deficiency development was increased OR = 1,096 (95% CI 0.39-3.02; p = 0.86). For BsmI, mean values of height, body mass, height SDS, serum 25(OH)D, in the studied population (16 children) were 123.49 ± 19.62 cm, 26.96 ± 11.11 kg, -2.25 ± 0.85, 48.86 ± 16.71 nmol/l, respectively; total calcium level consisted of 2.40 ± 0.12 mmol/l, serum phosphorus – 1.43 ± 0.11 mmol/l.
Conclusions: The allele frequency of the VDR BsmI polymorphism was 62.5% for the G allele (n = 20) and 37.5% for the allele A (n = 12). The G allele carrier of the polymorphic
locus BsmI rs1544410 of the VDR gene (rs11568820) is associated with an increased risk of growth hormone deficiency development OR = 1.31 (95% CI 0.62-2.75; p = 0.47).
RESULTS OF QUESTIONING PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN THE CONDITIONS OF DENTAL PRACTICE
Authors: Emelyanov Dmitry V.
Published: April 2021

The aim: Is to develop and test questionnaires allowing systematization of the main dental complaints and knowledge on hygienic oral care in patients with non-alcoholic fatty liver disease (NAFLD) given their individual characteristics.
Materials and methods: The developed questionnaires and database have been tested on 36 patients with NAFLD and 10 patients of the control group.
Results: As a result of the study, it appears that the main dental complaints in patients with NAFLD are dry mouth and the associated need for frequent mouth rinsing with
water, bleeding gums, mainly during teeth brushing, distortion of taste and bad breath. It has been noted that only 33.3% of patients regularly brush their teeth every morning
and evening, while 25.0% of respondents brush their teeth only once a day. It is also characteristic that more than 25.0% of patients with NAFLD use mainly carbohydrate foods in their diet, and the smoking rate among this group is at least 58.0%.
Conclusions: The use of this questionnaire makes it necessary to take into account all the “bottlenecks” in selection of measures for dental disease prevention in NAFLD, which currently is of high relevance and necessity.
STUDY OF RELATIONSHIP OF PSYCHOSOCIAL FACTORS WITH SMOKING IN NORTHERN POPULATION
Authors: Borisova Natalia V. , Markova Sardana V. , Malogulova Irina Sh.
Published: April 2021

The aim: Of our study was to identify the relationship between the main risk factors for heart disease and social factors among northern population.
Materials and methods: We polled 3092 native and non-native habitants of the Sakha Republic (Yakutia). The poll consists of several sections. It includes questions related
to social, demographic and life record data, heredity, physical activity and unhealthy habits.
Results: Among the people diagnosed with hypertension (HT), there are more smokers than among the people without this medical condition. On the contrary, in the group
of people diagnosed with HT at the examination for taking blood pressure, there were fewer smokers than in the group, in which HT was not registered. Patients with CHD,
Myocardial infarction (MI) in past medical history, cerebrovascular accident (CVA) and type 2 diabetes (T2D), are smokers to the same degree as the other group. This indicates
that this category of the examined are exposed to the risk of cardiovascular aggravations. We determined a high spread of psychosocial risk factors for the examined respondents
– the relationship between smoking, overweight, obesity, abdominal obesity and HT, and the level of education, marital status and labor specificity. The increase in the level
of education is associated with fewer amounts of smokers among both non-native and native habitants. Overweight is more frequently observed for the people who are not
single, have low level of education and are engaged in manual labor. In particular, it is applicable to native habitants.
Conclusions: Abdominal obesity did not have any relationship with psychosocial factors for native habitants. However, in relation to non-native habitants, overweight, obesity, abdominal obesity and HT are associated with marital status (married) and with manual labor.
THE PRINCIPLE OF COMBINED PREOPERATIVE DIAGNOSIS OF THYROID TUMORS
Authors: Zalyubovska Olga I. , Hladkykh Nadiia O. , Gritsenko Petro O.
Published: April 2021

The aim of the research is to increase the effectiveness of preoperative diagnosis of patients with thyroid tumors and to assess the use of cancer-embryonic antigen and
immunocytochemical research.
Materials and methods: Patients were interviewed about their complaints and lifestyle; performed ultrasound with fine-needle aspiration, determination of the level of
cancer-embryonic antigen (CEA), cytological and immunocytochemical researches.
Results: The Benign process in the thyroid gland is low serum REA (less than 0.95 ng / ml), poor expression of thyroglobulin (77.8%), negative reaction with TTF-1 (100%) and
cytokeratin-19 (55.6%). Differential-prognostic markers of thyroid neoplasms with risk of malignancy include increased serum REA (0.95 ng / ml and above), the presence of a
moderate reaction with antibodies to thyroglobulin (80.0%), a positive reaction — to TTF-1 (100.0%) and E-cadherin (90.0%), with moderate or strong expression of cytokeratin-19 (90.0%). Statistically significant markers of malignant thyroid disease were determined: the presence of harmful factors at work (45.5%), smoking (27.3%), elevated serum REA (0.95 ng / ml and above), the presence of strong cytoplasmic expression of thyroglobulin (63.6%), moderate or strong expression of TTF-1 (90.9%) and cytokeratin-19 (81.8%).
Conclusions: The most appropriate and practically significant for preoperative diagnosis of thyroid tumors is a set of several diagnostic methods, which are carried out in one hospital – ultrasound with fine-needle aspiration, cytomorphological, and immunocytochemical and REA levels in a primary screening.
USE OF MODERN CLOUD SERVICES IN RADIOLOGICAL DIAGNOSTICS TRAINING
Authors: Stuchynska Natalia V. , Belous Igor V. , Mykytenko Pavlo V.
Published: April 2021

The aim: Is to present and substantiate approaches to the organization of radiation diagnostics training using cloud services. Materials and methods: The experimental research was carried out at on 306 students of the Bogomolets National Medical University. To perform the set tasks, some theoretical and empirical methods of scientific research were used, namely: system analysis method, bibliosemantic method, statistical method, modeling method. Results: The expediency of building a hybrid digital environment, which combines the capabilities of the corporate and public cloud service and allows one to create an information system of personalized access to electronic educational resources was justified. This environment is implemented within the cloud service Nextcloud. The basic components of radiological diagnostics training by means of network technologies are considered and characterized. An experimental test of the effectiveness of the cloud services use is conducted in the process of training radiological diagnostics. Conclusions: The expediency of creating a modern digital educational environment based on the Nextcloud service for training radiological diagnostics has been justified. Moreover, it is demonstrated that pedagogically balanced and reasoned introduction of cloud services in the educational process promotes increased efficiency of educational process of radiological diagnostics.
DYNAMICS OF STUDENTS' FITNESS LEVEL WHILE DIFFERENTIATING PHYSICAL EDUCATION CLASSES IN ACCORDANCE WITH THEIR HEALTH AND NOSOLOGY OF DISEASES
Authors: Griban Grygoriy P. , Kuznіetsova Оlena T. , Lyakhova Natalia A. , Prystynskyi Volodymyr M. , Oleniev Dmytro G. , Otravenko Olena V. , Pantus Olena O.
Published: April 2021

The aim: Is to study the dynamics of students' physical fitness level while differentiating physical education classes in accordance with their somatic health and nosology of diseases.
Materials and methods: The paper presents the results of a study of the dynamics of the physical fitness indicators of students in the process of physical education. The
study involved 660 students between the ages of 17 and 25. Testing of students' physical fitness was performed using the method of control measurements. Research methods included the theoretical analysis and generalization of scientific and methodical literature, pedagogical observations, testing, pedagogical experiment, and the methods of mathematical statistics.
Results: At the end of the experiment, the students of the experimental groups (both male and female) showed authentically (р<0.05–0.001) better indicators of the control
tests than the students of the control groups.
Conclusions: It was established that the introduction of the original program of differentiating classes in accordance with the level of students' somatic health and nosology of diseases into the process of physical education has a positive effect on their physical fitness level. This will help to improve their learning and future professional activities.
MEDICO – SOCIAL SUBSTANTIATION OF THE CONCEPT OF PERSONALIZED MEDICINE IN THE PREVENTION OF ARTERIAL HYPERTENSION AMONG THE ADULT POPULATION
AT THE REGIONAL LEVEL
Authors: Lashkul Zinaida V. , Lashkul Dmytro A.
Published: April 2021

The aim: Is to scientifically substantiate the concept of personalized medicine in the prevention of arterial hypertension (AH) among the adult population at the regional level.
Materials and methods: The study, after obtaining informed consent, involved 2000 patients, residents of Zaporizhzhia Region, including 1000 patients (average age 59±0.5
years, the ratio of men to women 1:1.22 people) with and 1000 patients (average age of whom is 62±0.7 years, the ratio of men to women is 1:1.1) without AH. The data of
the sociological survey were processed, the methods of mathematical modeling, statistical, system analysis were applied. Odds ratio (OR) is determined by generally accepted
methods with the calculation of 95% of confidence interval (CI).
Results: The application of the concept of personalized medicine in the prevention of AH among the adult population has been scientifically substantiated by studying the
associations between medical and social risk factors and the development of AH and determining on their basis 3 modules – “risk behavior”, “adverse health factors” and “social determinants of the development of AH”, based on stepwise multiple logistic regression analysis.
Conclusions: It has been proved that the use of the final prognostic model of the development of arterial hypertension with the inclusion of the most significant risk factors has high operational characteristics: sensitivity – 78.6%, specificity – 96.6%, positive predicative value – 95.85%, negative predicative value – 81.86%, the area under the ROC curve is 0.9623. The application of the concept of personalized medicine in the prevention of this disease among the adult population was substantiated by studying the associations between medical and social risk factors and the development of arterial hypertension.
HEALTH CARE EXPENDITURES OF 179 COUNTRIES WITH DIFFERENT GNI PER CAPITA IN 2018
Authors: Vezhnovets Tatiana A. , Gurianov Vitalyi G. , Prus Natalia V. , Korotkyi Oleksandr V. , Antonyuk Olena Y.
Published: April 2021

The aim: To study the difference in health care expenditures in groups of countries with different GNI per capita.
Materials and methods: In 4 groups of countries with different GNI per capita were analyzed indicators of Current health expenditure per capita ($) (СHE), Domestic general
government health expenditure per capita, PPP ($) (GGHE $) and GGHE%, Domestic private health expenditure per capita, PPP ($) (PHE) and PHE%, Out-of-pocket expenditure (%)
(OOP), Current health expenditure (% of GDP) (CHE% GDP).
Results: The group of high-income countries differs by CHE, GGHE $, GGHE%, PHE $, PHE%, OOP, CHE% GDP (p <0.001), the group with incomes above the average – by CHE,
GGHE $, PHE $, PHE%, CHE%GDP (p <0.001). Groups with lower average income and low income do not differ in CHE, GGHE$, PHE$, PHE%, OOP (p> 0.05). GNI per capita
has a positive effect on GDP%GDP, CHE, GGHE, PHE in the high-income group and negatively affects the OOP (p <0.05), GNI per capita has a positive effect on CHE, GGHE in the above-average income group, GNI per capita has a positive effect on CHE, GGHE, GGHE%, PHE and negatively affects OOP (p <0.05) in the income group below average. GNI percapita has a positive effect on the OOP and negatively affects the CHE%GDP (p <0.05) in the low-income group.
Conclusions: Each group of countries, depending on per capita income, has its own health care costs.
IMPROVING DENTAL HEALTH – IS IMPROVING QUALITY OF LIFE
Authors: Zhachko Nataliia I. , Nespriadko-Monborgne Tamara S. , Skrypnyk Iryna L. , Zhachko Maksym S.
Published: April 2021

The aim: To assess the impact of dental status on the quality of life of the adult population in the presence of periodontal disease in combination with musculoskeletal dysfunction
in patients with dental anomalies and deformities.
Materials and methods: To study this goal, we examined 283 patients who complained of an aesthetic defect of the dentition, combined with the presence of joint pain and
periodontal disease of varying severity.
Results: received a complete analysis of factors that significantly affected the quality of life of patients with a lot of diseases of the oral cavity.
Conclusions: Oral health deficiencies reduce the quality of life of our patients, and the treatment significantly changes its quality depending on age, sex and method. But the
best results in achieving positive changes in the quality of life of the patient dentists can expect only by conducting a comprehensive treatment.
HYGIENIC ASPECTS OF LIFESTYLE OF KHARKIV NATIONAL MEDICAL UNIVERSITY JUNIOR STUDENTS IN THE CONDITIONS OF QUARANTINE
Authors: Korobchansky Volodymyr O. , Oliinyk Yuliia O. , Nesterenko Valentyna G. , Sarkis-Ivanova Vladyslava V. , Hryhorian Olena V.
Published: April 2021

The aim: To assess the impact of adverse factors on the lifestyle and health status of students in conditions of prolonged isolation.
Materials and methods: Data collection was carried out by anonymous survey using the survio.com online survey service. The study involved 273 students of Kharkiv National
Medical University: 47 men (17,2%) and 226 women (82,8%) aged 17 to 20. Age of 85% of respondents is 18-20 years old. 38 (13,9%) students are from 21 to 25 years old and
3 students (1,1%) – over 25 years old.
Results: A comparative analysis revealed the characteristic changes in the students' lifestyle. If under normal conditions the majority of students (63.7%) use their free time
for walks outdoors, and 46.5% spend it at the computer, then during quarantine most respondents spend leisure time in front of a computer monitor (64.8%) or watching TV
(71.4%). These indices were the result of a direct restriction on the interaction of students with the environment and the prohibition of their stay outside the zone of residence.
Conclusions: The most common negative changes of the students' health were sleep disturbances and headaches.
The second most common symptoms are changes in the musculoskeletal system, associated mainly with physical inactivity.
The third ones are deterioration of vision and psycho-emotional state of students.
DEVELOPMENT OF PERINATAL MEDICINE IN UKRAINE IN THE CONTEXT OF INTERNATIONAL APPROACHES
Authors: Moiseienko Raisa O. , Gojda Nina G. , Dudina Olena O. , Bodnaruk Nataliya M.
Published: April 2021

The aim: To realize analysis and assessment of completeness and efficacy in the field of perinatal aid regionalization in Ukraine.
Materials and methods: A retrospective analysis has been carried out as well as assessment of inculcation steps concerning regionalization of perinatal health care in Ukraine
according to the data of state and branch statistics and monitoring (in 2013-2017). The methods used here are systemic approach, bibliography method, and statistical data
evaluation.
Conclusions: It is shown the modern globally acknowledged three-level system of perinatal health care has been organized and functions in Ukraine, perinatal tertiary level
centers are now act in the majority of regions. The perinatal health care realization during these last years is shown to be able to assure the providing of adequate perinatal aid
taking into consideration the calculated data concerning the pregnant women concentration with high perinatal risks in third level institutions; these patients include pregnant
women with heart defects (63.2-69.9%), circulatory system defects (48.5-50.5%), diabetes mellitus (46.7-53.3%); in institutions of the second-third levels, there are 74.2-
83.0% of patients with severe gestoses. According to functional possibilities of perinatal aid institutions of different levels, they assure 62%-64.5% of births with body mass
500-999 g and 53.9%-55.3% of ones with body mass 1000-1499 g in perinatal clinics of the third level; it guarantees the survival of newborn babies with body mass 500-999
g and 1000-1499 g during their first 168 h reaching 60.1–65.1% and 89.4%-90.4%, respectively.
Efficacy of perinatal aid regionalization is confirmed by a positive tendency of perinatal mortality index; it has become significantly lower: in 2010, the perinatal mortality
reached 10.54 cases per 1,000 of newborn alive and dead babies, this index having dropped to 8.89 in 2019. The maternal mortality levels have also decreased from 23.5 up to
14.9 cases per 100,000 of babies born alive.
Perinatal aid regionalization in Ukraine is being realized according to international strategies permitting to provide effective perinatal aid to patients at each level of its provision
depending on patient's need.
HEALTH OF THE TEACHER OF HIGHER EDUCATION INSTITUTIONS (EFFICIENCY – DEVELOPMENT)
Authors: Dubovyk Olena M. , Dubovyk Violetta Y.
Published: April 2021

The aim: Of the work is to find a scientifically based approach to improve the health of teachers on the basis of a comprehensive socio-hygienic analysis of the factors that affect
the state of their health. Identify the main aspects of psychological work with teachers to support the mechanisms of self-regulation of their psychological health.
Materials and methods: Theoretical and methodological analysis of psychological and pedagogical literature; сomparison; generalization; systematization.
The article presents the current problem of modernity – the mental health of teachers of higher education. Criteria, quality categories, levels, principles of ensuring the mental
health of the teacher as a person are analyzed. The components of mental health are compared.
Conclusions: The concept of professional psychological health as a process of scientific understanding of the teachers practice involves the development of a comprehensive
program for teacher's health care, which will include all areas: informational, preventional, diagnostical, rehabilitational and treatment.
Higher education teachers are active participants in the preservation and promotion of health at the state, social and personal levels. They should form the concept of health
in students during the process of their professional activities. Teachers use various forms of organizational, educational, volunteer work and different new technologies to
preserve their own health and create the environment with the appropriate social conditions, where students can take responsibility for their own actions, deeds, work, leading
a healthy lifestyle.
WOMEN'S MODERNISM IN MEDICAL SCIENCE OF WESTERN UKRAINE – SOFIA OKUNEVSKA-MORACHEVSKA, SOFIA PARFANOVYCH AND VOLODYMYRA KRUSHELNYTSKA
Authors: Stytsiuk Natalia V. , Zolotarova Zhanna M. , Stovban Iryna V. , Yukish Halyna Y.
Published: April 2021

The aim: The purpose of this article is to identify through the analysis of biographical and scientific Sofia Okunevska-Morachevska, Sofia Parfanovych and Volodymyra
Krushelnytska common features of personal and professional development to understand the scientific, social and cultural parts of their activities in the context of the history
of national medical tradition.
Materials and methods: We will try to consider in general terms the life and professional path of Sofia Okunevska-Morachevska, Sofia Parfanovych, Volodymyra Krushelnytska,
highlighting common features and analyzing them in contexts of social, political, and cultural features of the era.
Conclusions: Analyzing the biographical milestones and scientific achievements of women physicians in Western Ukraine in the late XIX – early XX century, we concluded that
these personalities of Ukrainian medicine can be combined with a number of characteristics, thus demonstrating the continuity and longevity of the national female medical
elite in Ukraine.
Hankel determinant for m-fold symmetric bi-univalent functions
Authors:   DEPARTMENT OF MATHEMATICS BURSA ULUDAG UNIVERSITY 16059 BURS,TURKEY, ALTINKAYA SAHSENE , YALCIN SIBEL ,   DEPARTMENT OF MATHEMATICS BURSA ULUDAG UNIVERSITY 16059 BURS,TURKEY
Published: April 2021

In this paper, we consider a general subclass H_{\Sigma _{m}}(\beta ) of \Sigma _{m} consisting of analytic and m-fold symmetric bi-univalent functions in the open unit disc \mathcal{U}. An estimate for the second Hankel determinant for m-fold symmetric bi-univalent functions are determined.
Escape from solutions stagnation. A Study on Ant System solving TSP
Authors:   DEPARTMENT OF MATHEMATICS AND COMPUTER SCIENCE NORTH UNIVERSITY CENTER AT BAIA MARE TECHNICAL UNIVERSITY OF CLUJ-NAPOCA VICTORIEI 76, 430122 BAIA MARE, ROMANIA, PINTEA CAMELIA-M. , IANTOVICS BARNA ,   PETRU MAIOR UNIVERSITY INFORMATICS DEPARTMENT TG. MURES¸, ROMANIA, POP PETRICA ,   DEPARTMENT OF MATHEMATICS AND COMPUTER SCIENCE NORTH UNIVERSITY CENTER AT BAIA MARE TECHNICAL UNIVERSITY OF CLUJ-NAPOCA VICTORIEI 76, 430122 BAIA MARE, ROMANIA, DEHMER MATTHIAS ,   PRODUCTION AND OPERATIONS MANAGEMENT, FACULTY OF MANAGEMENT UNIVERSITY OF APPLIED SCIENCES UPPER AUSTRIA WEHRGRABENGASSE 1-3, 4400 STEYR, AUSTRIA,   UMIT THE HEALTH AND LIFE SCIENCES UNIVERSITY, HALL IN TYROL, AUSTRIA E-mail address: matthias.dehmer@umit.at
Published: April 2021

Nowadays, routing problems arise in different contexts of distribution of goods, transportation of commodities and people. Routing problems deals with traveling along a given network in an optimal way. One of the major goals in optimization, including optimization of routing problems, is to reduce the time of stagnation by finding an exit state. The current work is a study about the ability of ants to escape from solution stagnation on a particular routing problem, the Traveling Salesman Problem.
Peranan Pembelajaran Agama Islam Dalam Pembentukan Karakter Religius Dan Toleransi Siswa Sekolah Dasar
Authors: Toto Nugroho Muhammad , Nurdin
Published: April 2021

Tujuan penelitian: Tujuan dari penelitian ini adalah untuk mendeskripsikan peranan Pembelajaran Agama Islam dalam membentuk karakterk peserta didik yang religious dan toleransi di Sekolah Dasar. Metodologi: Penelitian ini menggunakan jenis penelitian deskriptif kualitatif, dimana sumber data yang diperoleh dari kegiatan observasi, wawancara, dan dokumentasi. Teknik analisis data yang digunakan menggunakan pendekatan penelitian kualitatif dimulai dari pengumpulan data, merduksi data, penyajian data dan penarikan kesimpulan. Temuan utama: Peranan pembelajaran Agama Islam dalam membentuk karakter religius dan toleransi pada diri peserta didik di SDN 59/V Bram Itam yaitu menerapkan membiasakan berdoa sebelum melakukan kegiatan belajar, mengucapkan salam, serta pembelajaran seperti membaca surah yasin setiap hari jum’at, hafalan surah-surah pendek dan doa sehari-hari. Keterbaruan penelitian: Bahwa pe,nelajaran agama di sekolah dasar memiliki keterkaitan dengan pembentukan karakter yang baik pada siswa.
Policy Context and Policy Creation: Migration and Translation Policy in Australia
Authors: GENTILE ADOLFO
Published: April 2021

Abstract The paper engages the theme “Migration, multilingualism and T&I policies”. It provides a reflection on the concept of translation policy viewed through the lens of migration. This reflection emanates from research carried out on the policy context
in the creation of the National Accreditation Authority for Translators and Interpreters in Australia. Current writing on translation policy (Gonzalez Nuñez and Meylaerts 2017, as a recent example) has tended to expand the coverage of this concept to embrace a number of aspects consistent
with a socio-political view of the place of translation and translation policy, the latter seen as a precursor or a consequence of the former. The paper explores the dependency of policy on the context in which it is framed and considers the need for a more specific approach to the examination
of the nature of translation policy as it not only relates to the rules, agency and practices but more importantly to the values inherent in particular instances or systems of translational communication. The paper utilizes examples derived mainly from the Australian context and will argue
that the terminology itself used in the elaboration and implementation of translation policy requires considerable refinement before it can be applied to different temporal and cultural contexts. One example of this phenomenon is the concept of ‘minority’ or ‘minorities’
which is not used in Australia in this context and is, in turn, a reflection of the values ascribed to a consideration of either migrant groups or allophone groups within a society. The paper argues for clearer distinctions between policies about permitting or mandating translation and policies
which impinge upon the conduct of translation since the source of authority and therefore policy-making, resides with different actors.
Professional Museum Translators for Promoting Multilingualism and Accessible Texts: Translation Practices in Some Italian Museums and a Proposal
Authors: MANFREDI MARINA
Published: April 2021

Abstract This article examines the role of museum translation in the contemporary world. More specifically, the paper advocates linguistic “accessibility” for museum target texts, focusing on a case study of three Italian museums. Combining a qualitative context-oriented
methodology and a theoretical approach, the paper draws on interviews with museum professionals in the city of Bologna, Italy, and puts forward a proposal for a linguistic training of professional museum translators who can tackle the challenge posed by multifunctional texts. The findings
suggest that, although translation is recognized by translation-related staff as a crucial activity in the internationalization of museums, translation practices are not systematic. Exploiting interdisciplinary connections between Translation Studies and Systemic Functional Linguistics, interfacing
with Museum Studies, the paper argues that an effective, “accessible” and “inclusive” museum text may be produced by a linguistically trained translator who is capable of conveying, in a different language, the “organizational”, “interactional”
and “representational” functions (Ravelli 2006) which are interlocked in a museum text. Authentic examples from panels and exhibit labels will be offered, dealing with the Italian-English language pair.