bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on Stability and Control of Pre-excavated Withdrawal Channel under Mining Influence
Authors: Zhang Hanrui , Liu Changyou , Yu Xin , Zhang Kun , Liu Huaidong
Published: December 2022

Pre-excavated withdrawal channel (PWC) is an effective means to shorten the withdrawal time of fully mechanized working face and improve the efficiency, safety, and reliability during the withdrawal. However, the key to the success of the withdrawal method is the influence of mining on the stability of PWC, taking the III32upper1 working face of Zhuzhuang Coal Mine as the engineering background. By theoretical analysis and numerical simulation, the deformation of the PWC is analyzed and the mechanical model of the influence of the instability of the main roof fracture on the PWC is established. And the effect of the fracture and rotation of the main roof on the PWC is analyzed. The result shows that the instability of the coal pillar leads to the fracture and rotary deformation of the main roof as the width of the coal pillar gradually decreases, which further aggravates the deformation of the PWC and the degree of ground pressure behavior. Based on the influence of mining on the PWC, a control method is proposed. This method uses hydraulic fracturing technology to weaken the mining stress and prevent the fracture of the main roof above the PWC. The control effect of hydraulic fracturing on PWC is analyzed through the establishment of numerical calculation model. The result of engineering practice demonstrates that the mining stress is significantly reduced, and the deformation of surrounding rock in the PWC is effectively controlled after hydraulic fracturing.
Implementación de la norma ISO 45001:2018 para mejorar la gestión del área de seguridad en la empresa Pilotes Terratet Perú - 2016
Authors:   , Malca Ugarelli Juan Rodrigo
Published: December 2022

El objetivo de la presente investigación es Implementar la ISO 45001:2018 para mejorar la gestión del área de seguridad estableciendo una política de seguridad, gestionar sus procesos de manera adecuada, generar objetivos alineados a la política, tomar acciones para garantizar el desempeño y asegurar la mejora continua, pero nada de esto será posible sin el compromiso de todos los niveles de la organización y sobre todo la alta dirección. Al concluir con la implementación y las capacitaciones necesarias para que la organización se comprometa y entienda la importancia del sistema de gestión de seguridad, se observó personal más consciente y comprometido con la identificación de riesgos y las medidas de control que se usan para mitigar dichos riesgos.
Efecto citotóxico de la Annona muricata frente a la línea celular de adenocarcinoma gástrico
Authors:   , Alvarado Mayor Paola Natalia , Bautista Flores Alexandra
Published: December 2022

Antecedente: Los avances terapéuticos frente al cáncer no han tenido el éxito esperado y presentan efectos adversos pocas veces tolerados por el paciente. Un estudio en Perú identificó el efecto anticancerígeno de la Annona muricata (AM), planta medicinal conocida como guanábana, en adenocarcinoma gástrico de ratón C-678 con resultados favorables, sin embargo, no se ha encontrado evidencia previa en células humanas. Objetivo: El objetivo de este estudio fue determinar el efecto citotóxico del extracto de AM frente a la línea celular de adenocarcinoma gástrico humano (AGS). Materiales y métodos: Estudio experimental in vitro tipo analítico con extracto hidroalcohólico de hojas de AM (AMOH) recolectadas en Amazonas. Mediante screening fitoquímico se identificaron los grupos funcionales químicos. Para obtener el efecto citotóxico, se añadieron diferentes diluciones de extracto a las placas que contienen las líneas celulares y mediante una ficha de observación los datos fueron extrapolados a GraphPad. Finalmente se expresó como la concentración inhibitoria media máxima (IC50) y se hizo un análisis de regresión no lineal con la finalidad de encontrar la cantidad de inhibición de crecimiento de células oncológicas. Resultados: En el screening fitoquímico se pudo identificar la presencia de carbohidratos reductores, alcaloides, fenoles, taninos, tritérpenos y esteroides, saponinas, flavonoides, proteínas, glicósidos cardiotónicos y antocianinas. Para identificar el contenido total de fenoles se utilizó la curva de calibración con ácido gálico el cual nos comprobó la presencia de una buena cantidad de estos metabolitos. Adicionalmente se utilizó quercetina para identificar el contenido de flavonoides, obteniendo resultados favorables ya que se hizo evidente su presencia. La línea celular AGS mostró una actividad citotóxica frente al AMOH con un IC50 a las 24 horas de 45.81ug/mL y 19.05ug/mL a las 48 horas. Conclusión: Se identifica la presencia de diversos metabolitos secundarios de la AM, y esta posee un efecto citotóxico contra la línea celular AGS.
‘It’s What I Do’
Authors: Kaipainen Sini
Published: December 2022

This close reading of the public persona outlines how high-profile war photojournalist Lynsey Addario articulated ‘it’s what I do’ in her public Instagram account construed as an ongoing digital memoir. Addario’s Instagram profile and her formal journalistic memoir, It’s What I Do: A Photographer’s Life of Love and War (2015), are fluid continuums of different forms and features that support, authenticate, and promote her public work persona, using various visual and literary techniques to articulate ‘it’s what I do’. Through self-life-writing, Addario blurs the distinction between public and private and incorporates her personal life into her work. The strategies common to autobiographical journalism, self-life-writing, and celebrity culture substantiate, authenticate, and promote her brand. Yet, complicating the professional life and persona with personal and intimate performances does not happen without critical concerns such as intimisation and celebritisation of conflict photojournalism. Findings shed light on public persona work in professional photojournalism through personalised, visual, and branded auto/biographical content on Instagram.
Persona Recovery through Homage
Authors: Acosta Angela
Published: December 2022

Tània Balló’s Las sinsombrero documentary series (2015-2021) about modern Spanish women led to the creation of multimedia projects and online spaces for paying homage to forgotten women throughout history. However, such crowdsourced and scholarly recuperation efforts are at odds with the prevailing canonization of the Spanish avant-garde artistic group known as the “Generation of 1927”. A deliberately constructed practice of homage has historically excluded women’s legacies and granted nearly exclusive support for the ten male poets considered the originators of the Generation of 1927. Modern women writers like María Teresa León and Concha Méndez lacked such cultural support and thus constructed personas in their life writing by placing themselves outside the sphere of influence of the Generation of 1927 despite their successful literary careers.
This creative piece brings together persona studies and homage to study how performances of prestige by writers and literary historians reveal the gendered, classed, and sexualised ways that the literary history of the Generation of 1927 has been constructed. My proposed theory of homage uncovers the closeted and undocumented sapphic and sororal relationships between women, and imagines queer feminist futures where women’s work is central to understanding the cultural milieux of the Generation of 1927. These poetic tributes are what I call “life-making homages” that celebrate and grant prestige to recuperated knowledge of writers’ queer, undocumented lives. The paper and accompanying poems demonstrate how, through life-making homages, scholars can propose alternate paradigms for tracing the development of the Generation of 1927 as part of Spain’s cultural heritage.
“Escape to Impersonality”
Authors: Greenberg Aaron
Published: December 2022

This article reads H.G. Wells’ Experiment in Autobiography (1934) through the lens of Persona Studies to situate life writing in the context of (post) human rights, biopolitics, and surveillance capitalism. Carl Jung’s concept of persona pervades Wells’ writing and life. Persona, for Wells, is the path towards the “impersonality” that is essential to humanity’s evolution. Wells recognized that personas are plural, inconsistent, and evolving performances whose fictional unity, if enacted deliberately without self-delusion, can serve real ends—such as the prolific creative and intellectual work that earned him four nominations for the Nobel Prize in Literature. Further, Wells presents life writing as a human right: the right to tell our own stories, access our own records, represent the personas which we elect, and enjoy the freedom to evolve from one persona to the next. A persona’s double movement, poised between the personal and the impersonal, the individual and the world, the biological and the historical, represents both the form and content of Wells’ Experiment in Autobiography. If Wells gives us reason to hope amidst a global pandemic, the specter of World War III, the proliferation of nuclear arms, and climate catastrophe, it is that these existential threats help us answer the question, “What will come after man?” To consider the answer is not to give up on humankind. On the contrary, to imagine non/post human lifeforms is essential in defining human rights and securing a human future.
Assembling Academic Persona and Personhood in a Digital World
Authors: Ortiz-Vilarelle Lisa
Published: December 2022

Digital automedia have become a standard mechanism for academics seeking to construct and promote their professional profiles. Through a range of autobiographical forms enabled by the digital age, on-line platforms, including blogs, Facebook groups, and Twitter, have become something of a business card for academics. But what about the self-authored personnel narratives that are not shared publicly and serve, nonetheless, as self-portraits of academic life?.  Even tenure and promotion applications, employment letters, and CVs, the most often required documents to gain and maintain access to professional opportunity in academia, are going digital. And they are evolving with the digital age. In some stages of personnel review, those requests are made and via digital methods. Software used for standardization and efficiency, mediates representation of academic subjectivity by restricting users to entering details according the parameters set not only by the standards of the profession, the institutional subscriber, but also by the operating system. Increasing reliance on such systems further reduces academic personhood to chartfields and biodigital data entry that is counter-intuitive to the syncretic processes of making meaning by which individuals experience, remember, and recount their lives inclusive of their careers. My essay turns to narrative theory to assess the impact of digital tools and methods of personnel review on the assemblage and portraiture of academic subjectivity.
Performing Lives, Producing Life
Authors: Lee Katja
Published: December 2022

This special issue on life writing and persona marks the 15th issue of Persona Studies and the culmination and end point of my eight years working as one of four Managing Editors of the journal. It is both fitting and very exciting then, to be able to wrap up this journey with an exploration of two fields that have long fascinated me: Life Writing Studies and Persona Studies. Indeed, life writing seems both an obvious and natural home for studying persona. The study of life writing has always involved the analysis of identities put into play and, it has become increasingly clear to me over the years, scholars of persona are equally fascinated by the kinds of persona work that life writing can do. Over the past fourteen issues, every single issue has had at least one contribution (often several) that used or drew upon life-writing texts.
Perovskite CsPbBr3 single-crystal detector operating at 1010 photons/s/mm2 for ultra-high flux X-ray detection
Authors: Pan Lei , Pandey Indra , Miceli Antonino , Klepov Vladislav , Chung Duck Young , Kanatzidis Mercouri
Published: December 2022

Semiconductors for detecting hard radiation are confronted with considerable problems when operating at high photon fluxes. We report a perovskite CsPbBr3 single-crystal detector capable of operating at X-ray fluxes of up to 1010 photons/s/mm2 with beam area ≤ 0.25 mm2 at 58.61 keV for current-mode X-ray detection. The spectrometer-grade CsPbBr3 detectors show a gamma-ray energy resolution of ~7.5% at 122 keV for 57Co and dark current as low as 4.3 nA (0.5 nA/mm2) at a reverse bias voltage of 200 V (118 V/mm). The detector was tested at X-ray energies of 8.2, 10, and 58.61 keV at a synchrotron light source under a reverse bias voltage of up to 1000 V (588 V/mm). Under a sufficiently high bias voltage and within several hundreds of seconds X-ray exposure, good photocurrent linearity (goodness of fit R2 > 0.99) and reproducibility were obtained up to a flux of ~ 1010 photons/s/mm2 at beam area 0.25 mm2 with Lower Limit of Detection of ~105 photons/s/mm2 and Charge Collection Efficiency of ~100% for 58.61 keV X-rays. Accordingly, wide application of CsPbBr3 detectors in high-flux X-ray detection is anticipated.
Designing an Analysis Framework for estimating life of a component subjected to a constant load and a single overload using MATLAB
Authors: Rauf Malik Nauman , Khan Rahma , Majeed Gohar
Published: December 2022

Actual Structures are subjected to variable amplitude loading as opposed to a monotone. Many models have been proposed to study these effects analytically. The proposed study focuses on developing an algorithm, and a corresponding framework in MATLAB for two of these models, i.e. the NASGRO equation for constant amplitude loading, and Generalized-Willenborg for overload effects. The overload influence is modeled by keeping track of changes in the crack-tip plastic-zone. Two cases are studied with the algorithm, and the results indicate that the presence of overload tends to retard crack growth, thereby validating our algorithm with literature findings.
Evidence of local adaptation in temperature tolerance traits of the gametophytic and sporophytic stages in Solanum carolinense (horsenettle)
Authors: Chandler Emma K. , Travers Steven E.
Published: December 2022

Climate change is rapidly altering local temperature regimes and in different ways across the landscape. To cope with these rapid changes, plant species must have the capacity to respond to changes in temperature stress or risk extinction. We compared temperature tolerance traits in Solanum carolinense populations from Texas and Minnesota to understand how a species adapts to extreme temperature stress. We examined traits in both the gametophytic and sporophytic stages to differentiate between these distinct phases of selection and determine whether there is a correlation between the two. We found that temperature sensitivity differed between populations of the south that face extreme heat regularly and northern populations that do not. The results were not completely consistent with our expectations, including counter-gradient results in both the sporophyte and gametophyte. There were also no correlations in temperature tolerance between the two life-stages, suggesting that there are different temperature tolerance strategies in the gametophyte and sporophyte. Our results support the adaptation of a potential avoidance mechanism to mitigate extreme heat in the gametophyte. These findings indicate that wild populations have the potential to adapt to rising temperatures due to climate change in the future.
Application of wetland waste plant biochar in combination with arbuscular mycorrhizal fungi on immobilization of Cd in contaminated soil
Authors: Qiu Liang , Zhu Qi lin , Luo Qing hua , Li Hai lan , Yan Jia li , Liao Tao , Li Xin
Published: December 2022

In this study, biochar pyrolyzed from different wetland waste plants (Reed,Typha,Canna) was used to immobilize Cd in contaminated soil. The results showed that biochar could all enhance the residual Cd2+in soil. Moreover, Ca500 (pyrolyzed at 500 ℃ fromCanna) showed the best immobilization capacity due to its larger surface, higher number of pores and its regular, smooth structure. Optimum conditions for Ca-500 immobilization to Cd2+in soil were: amount 6% (wt%) and contacting time 16 weeks, the exchangeable and the state of bound to carbonates of heavy metals reduced 92.08% and 67.64%, respectively. After combining biochar with arbuscular mycorrhizal, the results showed that the combined system could more effectively reduce the transportable Cd content in soil, increase the proportion of residual Cd, effectively reduce the migration of Cd, improve the biomass and root length of vegetables, reduce Cd absorption by vegetables and the ability of vegetables to transfer Cd from root to the upper part, and reduce the edible safety risk. Simultaneously, biochar with arbuscular mycorrhizal can improve the antioxidant capacity of vegetables and their resistance to heavy metals, optimize the composition of soil microbial community, and improve soil microbial abundance and community β-diversity. It can also significantly change the functional gene expression of soil microorganisms, soil fertility, and the self-healing ability to heavy metals.
Routine (7 days) vs. clinically indicated change of the noninvasive ventilator circuit for prevention of hospital-acquired pneumonia: Protocol for a randomized controlled trial in 2 tertiary hospitals
Authors: Zhang Xiaolong , Zhu Jing , Wang Lili , Wu Ying , Lin Ji , Wang Minjin , Wang Feng , Zeng Yihua , Wang Wenxiu , Han Yao , Feng Mei , Zhang Xuan
Published: December 2022

Background

The change frequency of the ventilator circuit was once thought to be the main cause of ventilator-associated pneumonia (VAP), but recent evidence has shown that it is not strongly relevant to VAP in invasively ventilated patients. However, circuits of noninvasive positive pressure ventilation (NPPV) are still routinely (every 7 days) changed in many hospitals to prevent hospital-acquired pneumonia (HAP) without evidence, which is a heavy economic burden on the health system.

Methods

This is a nonblinded, prospective, randomized controlled multicenter trial. Patients who receive NPPV onset in this hospitalization will be screened for eligibility. A total of 340 eligible participants will be stratified (3:2) in two research sites and will be randomly allocated to routine changes in the ventilator circuit group or clinically indicated changes in the circuit group at a ratio of 1:1. Routine prevention for HAP will be provided in both groups. The primary outcome is the occurrence of HAP 48 hrs after NPPV therapy starts or 48 hrs within weaning from NPPV. Secondary outcomes include the length of hospital stay, length of each circuit duration, NPPV treatment days, intubation, mortality and direct cost of the circuits and antibiotics. The growth curve of microorganisms in the ventilator circuit will also be analyzed. It is hypothesized that there will be no difference in the occurrence of HAP in the two arms. Furthermore, a decrease in circuit cost is expected in the intervention group, and the microorganisms in the ventilator circuit are predicted to not increase over time.

Discussion

NPPVs are widely used in patients with various diseases from different healthcare settings. Evidence-based rules for changing NPPV circuits are limited. If supported, our pioneer study will provide a cost-effective NPPV management method without increasing the risks of HAP.
Functional characterization of a Na+/H+ antiporter salt overly sensitive 1 gene, LpSOS1, involved in positively regulating salt response from Lilium pumilum
Authors: Yang Yue , Ming Jun , Xu Leifeng , Li Wenxiang , Cao Yuwei , Bi Mengmeng , Liang Rui , Yang Panpan
Published: December 2022

Lilium pumilum has a strong salt tolerance. However, its molecular mechanisms underlying salt tolerance remain unexplored. In this study, a plasma membrane Na+/H+ antiporter gene, LpSOS1, was cloned from L. pumilum. The expression level of LpSOS1 in L. pumilum was significantly upregulated in the presence of high NaCl concentrations (100 mM). Localisation analysis in tobacco epidermal cells showed that the LpSOS1 protein was found in the plasma membrane. Overexpression of LpSOS1 in Arabidopsis enhanced tolerance to salt stress, as indicated by a lower malondialdehyde content; higher levels of the related antioxidant reductases superoxide dismutase, peroxidase, and catalase; and a decreased Na+/K+ ratio in transgenic plants. SOS1 mutant and wild-type (WT) Arabidopsis plants expressing LpSOS1 grew better, with higher biomass, root length, and lateral root quantity, when treated with NaCl, whereas WT and SOS1 mutant Arabidopsis plants were wilted, chlorotic, and even died under salt stress. Moreover, the transcript levels of stress-related genes were significantly higher in LpSOS1-overexpressing lines than in WT plants under salt stress. These results suggest that LpSOS1 improves plant salt tolerance by regulating ion homeostasis, reducing Na+/K+ in plants, protecting the plasma membrane from oxidative damage under salt stress, and enhancing antioxidant enzyme activity.
Exosomal miR-29a-3p in the immune microenvironment of spleen deficiency promotes hepatocellular carcinoma lung metastasis by activating FAM167A-α1-integrin-NF-κB signaling axis
Authors: Luo Jin , Chen Qiu-Xia , Li Pan , Yang Zhi-Ming , Yu He , Liu Bao-Qi , Fan Mei-Ling , Mo Zhuo-Mao , Wang Yong-Dan , Zhou Mei-Ling , Hu Hao , Yu Ling , Huang Bi-Jun , Zhang Shi-jun
Published: December 2022

Background
Hepatocellular carcinoma (HCC), a common type of cancer, has a strong metastatic ability and poor prognosis. The tumor microenvironment is the “soil” for the occurrence and development of tumors, with exosomes playing an important role in these processes. In traditional Chinese medicine(TCM), the tumor microenvironment corresponds to the internal environment of the syndrome known as spleen deficiency (SD). Numerous studies have shown that exosomes contain high levels of miRNAs, which have been shown to contribute to tumor immune regulation and metastasis. The aim of this study was to explore the mechanisms underlying the changes in the tumor microenvironment under the condition of spleen deficiency in order to find better treatments for cancer.
Methods
The effects of exosomal miR-29a-3p on lung metastasis from hepatocellular carcinoma (HCC) were evaluated using the scratch test, migration test, mouse SD model, HCC model, and tail-vein injection model of lung metastasis. The western blot assay, ELISA, flow cytometry, luciferase reporter gene analysis, qRT-PCR and immunofluorescence staining were among the methods used to study the molecular mechanism of lung metastasis promotion under the SD internal environment.
Results
Compared with the mice with HCC only, the mice with HCC and SD symptoms secreted more miR-29a- 3p-enriched exosomes, and their tumor tissue expressed significantly higher levels of α1-integrin and lower levels of FAM167A. These changed the immune microenvironment of mice (Decreased infiltration of T cells (CD3+CD4+ and CD3+CD8+), activated α1-integrin-NF-κB signaling pathway, and secreted more interleukin inflammatory factors(IL-1β, IL-6, and IL-8), which promoted the invasion and infiltration of HCC and its lung metastasis both in vivo and in vitro. In a series of patients with liver cancer, SD was found to have affected their overall survival and relapse-free survival.
Conclusion
Our study showed that under conditions of SD, the body releases more miRNA-containing exosomes, changes the immune microenvironment of the body, and ultimately promotes tumor metastasis and growth. These results highlight potential therapeutic targets and methods for the prevention of cancer metastasis, which may help to screen possible anticachexia TCMs and elucidate its mechanism in the future.
10-Year-Childhood Malignancy Profile Province-Wide in Indonesia (2009- 2018): Yogyakarta Pediatric Cancer Registry
Authors: Supriyadi Eddy , Purwanto Purwanto , Armytasari Inggar , Ritter Julie , Widjajanto Pudjo Hagung , Veerman AJP
Published: December 2022

Background
This study aims to present an epidemiological profile of childhood malignancies diagnosed in Dr. Sardjito General Hospital from January 2009 to December 2018 and compare it with previous study1.
Methods
Childhood cancer was diagnosed in children aged 0–18 years, from January 2009 to December 2018, and analyzed. Childhood malignancies were categorized based on age, sex, and disease group according to the International Classification of Childhood Cancer. An estimated annual average incidence rate of childhood cancer was calculated. We visualized the number of patients and their regions of origin by geographic mapping.
Results
There were 1,788 new cases registered in Yogyakarta Pediatric Cancer Registry during the study period. The mean age at diagnosis was 6.3 years old with male-to-female ratio 1.4:1.0. Of these 56% of cancers were diagnosed in the age group of 0–5 years old. The most common diagnosis category was leukemia, which accounted for 60% of all childhood malignancies. The three most common diagnoses included: acute lymphoblastic leukemia (44%), acute myeloid leukemia (13%), and retinoblastoma (6%). The annual average incidence rate of leukemia and solid tumors was 26.8 and 17.5 per million, respectively.
Conclusions
There was an increase 60% in the number of childhood malignancies in 2009–2018 compared to the 2000–2009 study. The number of patients referred to our hospital increased, indicating a better registry, better referral system and better access to health care facility due to Universal Health Coverage.
The dermatochalasis of the lower eyelid: A possible aetiology for involutional entropion
Authors: Li Qingji
Published: December 2022

Purpose
To analyze the relationship between dermatochalasis and the orbicularis retaining ligament (ORL) and their effect on involutional entropion.
Methods
Ninety-two eyelids of 68 patients with involutional entropion underwent surgery to remove the prolapsing fat, plicate the lateral canthal tendon or use a lateral tarsal strip procedure, advance the retractor, resect the excess skin with OOM and tighten the OOM by securing the OOM flap to the periosteum, and had a postoperative follow-up of 12 ~ 18 months.
Results
Eighty-eight of 92 eyelids had a satisfactory outcome with normal eyelid positioning and pleasing cosmetic results. Four eyelids showed ectropion, but all of them improved in three months. No recurrence was observed in this study.
Conclusions
The dermatochalasis may be an aetiology of involutional entropion. The relaxed skin could be retracted upward by the ORL, and the skin is then rolled over the superior tarsal border and pressed against the globe. Our procedure addressed most factors and is a useful technique for involutional entropion.
Gut microbiota and acylcarnitine connect the beneficial association between estrogen and lipid metabolism disorders in ovariectomized mice
Authors: Ma Baohua , Zhang Ke , Guo Mengmeng , Cao Xi , Ji De , Xiong Hui , Zhang Ting , Wu Yujiang , Suo Langda , Pan Menghao , Brugger Daniel , Chen Yulin
Published: December 2022

Decreased estrogen levels are one of the main causes of lipid metabolism disorders and coronary heart disease in women after menopause. Exogenous estradiol benzoate is effective to some extent in alleviating lipid metabolism disorders caused by estrogen deficiency, but the role of gut microbes in the regulation process is not yet clear. The objective of this 45 days randomized trial was to investigate the effects of estradiol benzoate supplementation on lipid metabolism, gut microbiota and metabolites in ovariectomized (OVX) mice, and revealing the important role of gut microbes and metabolites in the regulation of lipid metabolism disorders. This study found that high doses of estradiol benzoate supplementation effectively attenuated fat accumulation in OVX mice and significantly altered the expression of genes enriched in hepatic cholesterol metabolism and unsaturated fatty acid metabolism pathways. Further screening of the gut for characteristic metabolites associated with improved lipid metabolism disorders revealed that estradiol benzoate supplementation influences major subsets of acylcarnitine metabolites, and ovariectomy significantly increased the abundance of characteristic microbes that were significantly negatively associated with acylcarnitine synthesis, including Lactobacillus and Eubacterium_ruminantium_group bacteria, while estradiol benzoate supplementation significantly increased the abundance of characteristic microbes that were significantly positively associated with acylcarnitine synthesis, including Ileibacterium and Bifidobacterium bacteria. The use of pseudo-sterile mice gut microbial deficiency greatly facilitates the synthesis of acylcarnitine due to estradiol benzoate supplementation and alleviates lipid metabolism disorders to a greater extent in OVX mice. Our findings established a role for gut microbes in the progression of estrogen deficiency-induced lipid metabolism disorders, and screened for key target bacteria that may have the potential to regulate acylcarnitine synthesis. These findings suggest a possible route for the use of microbe or acylcarnitine to regulate estrogen deficiency-induced disorders of lipid metabolism.
Exploring cognitive and affective outcomes following bilateral 6-hydroxydopamine lesions of the substance nigra or striatum in rats
Authors: Mattos Bianca Andretto , Bonato Jéssica Mendes , Guimarães Elaine Del Bel , Milani Humberto , Oliveira Rúbia Maria Weffort
Published: December 2022

Purpose: The majority of animal models of Parkinson’s disease (PD) focus on motor symptoms that are induced by unilateral injections of such neurotoxins as 6-hydroxydopamine (6-OHDA) in nigrostriatal dopaminergic pathways. However, motor changes that are induced by unilateral 6-OHDA injections may interfere with the identification of cognitive and affective dysfunction induced by dopaminergic neurodegeneration.
Material and Methods: To select an appropriate method for studying nonmotor symptoms of PD and potential neuroprotective treatments, the present study compared behavioral effects of bilateral 6-OHDA infusions directly in the substantia nigra pars compacta (SNpc) or striatum in rats. A battery of behavioral tests, including affective and cognitive tasks, was performed for 22 days after nigrostriatal lesions.
Results:The massive degeneration of tyrosine hydroxylase-immunoreactive neurons was observed in the SNpc, striatum, and ventral tegmental area with 6-OHDA infusions in either the SNpc or striatum. With regard to functional outcomes, 6-OHDA infusions in the striatum decreased general exploratory activity 7 days after the lesion. Rats that received 6-OHDA in the SNpc exhibited cognitive impairments and despair-like behavior. A decrease in the number of newborn neurons was found in the hippocampus in rats that received 6-OHDA in the striatum, indicating a decrease in neurogenesis. 6-OHDA infusions in both the SNpc and striatum impacted the maturation of newborn hippocampal neurons.
Conclusions: These results indicate that bilateral injections of 6-OHDA in the SNpc might be appropriate for studying nonmotor symptoms of PD.
Job-shop scheduling problem and its solution method
Authors: Tsirlin A.M. , Balunov A.I.
Published: December 2022

The paper discusses a variation of the job-shop scheduling problem, its formal definition and solution methods. The variation takes into account the schedule of service points and their location. The authors propose an algorithm for solving the problem. The solution is reduced to multiple assignment problem solving using the branch-and-bound method. To determine the optimality criterion, the authors use both lower- and upper-bound estimates.
CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in acute ischemic stroke
Authors: Wang Meng , Li Hong , Qian Yulin , Zhao Shanshan , Wang Hao , Wang Yu , Yu Tao
Published: December 2022

Purpose
We investigated the role of CircRNA_0000927 on the occurrence and development of acute ischemic stroke (AIS) and neuronal injury by targeting the miR-126a-5p/PGC-1α axis to find a novel clinical drug target and prediction and treatment of AIS.
Methods
The mouse AIS animal model was used in vivo experiments and hypoxia/reoxygenation cell model in vitro was established. Firstly, infarction volume and pathological changes of mouse hippocampal neurons were detected using HE staining. Secondly, rat primary neuron apoptosis was detected by flow cytometry assay. The numbers of neuron, microglia and astrocytes were detected using immunofluorescence (IF). Furthermore, binding detection was performed by bioinformatics database and double luciferase reporter assay. CircRNA_0000927 localization was performed using fluorescence in situ hybridization (FISH). CircRNA_0000927, miR-126a-5p and PGC-1α mRNA expression was performed using RT-qPCR. NLRP3, ASC, Caspase-1 and PGC-1α protein expression was performed using Western blotting. IL-1β was detected by ELISA assay.
Results
Mouse four-vessel occlusion could easily establish the animal model, and AIS animal model had an obvious time-dependence. HE staining showed that, compared with the sham group, infarction volume and pathological changes of mouse hippocampal neurons were deteriorated in the model group. Furthermore, compared with the sham group, neurons were significantly reduced, while microglia and astrocytes were significantly activated. Moreover, the bioinformatics prediction and detection of double luciferase reporter confirmed the binding site of circRNA_0000927 to miR-126a-5p and miR-126a-5p to PGC-1α. CircRNA_0000927 and PGC-1α expression was significantly down-regulated and miR-126a-5p expression was significantly up-regulated in AIS animal model in vivo. At the same time, the expression of inflammasome NLRP3, ASC, Caspase-1 and pro-inflammatory factor IL-1β was significantly up-regulated in vivo and in vitro. The over-expression of circRNA_0000927 and miR-126a-5p inhibitor could inhibit the neuron apoptosis and the expression of inflammasome NLRP3, ASC, Caspase-1 and pro-inflammatory factor IL-1β and up-regulate the expression of PGC-1α in vitro. Finally, over-expression of circRNA_0000927 and miR-126a-5p inhibitor transfected cell model was significant in relieving the AIS and neuronal injury.
Conclusion
CircRNA_0000927 promotes inflammatory response to neuronal injury via miR-126a-5p/PGC-1α axis in AIS.
Energy gaps and plateau characteristics in the fractional quantum Hall effect derive from multi-particle correlations
Authors: Hong Jongbae
Published: December 2022

The energy gaps appearing in the fractional quantum Hall effect (FQHE) remain an important aspect of investigation. Moreover, the plateau widths in the Hall resistance have been considered simply an effect of disorder as in the integral quantum Hall effect. The existing theories could neither explain the Hall resistance curve owing to plateau widths nor calculate the energy gaps. This study reveals that both the energy gaps and plateau widths contain fundamental many-body aspects of the FQHE, and they are found to be connected via the strengths of multi-particle correlations, which do not affect the vertical positions of plateau that are automatically quantized just by the presence of inter-electron interaction. This work focuses on correlated electrons moving through the edge of an incompressible strip formed within a Hall bar. Consequently, a single-particle Hamiltonian was constructed incorporating the Zeeman energies of multiply-correlated skipping electrons. The resulting energy spectrum exhibits hierarchical Landau level splits according to correlation order. The lowest Landau level is examined. Based on such level splitting, a previously measured Hall resistance curve and energy gaps are quantitatively explained by determining the parameters that describe the degrees of multi-particle correlations. The chemical potential and effective g-factors are additionally predicted.
Measurement of the Reynolds Number Dependence of a Transient Air Jet from a Pressure Vessel
Authors: Fischer Michael-David , Ryll Fabienne , Boettcher Konrad E.R.
Published: December 2022

Although a free jet is a well investigated problem in literature, there are still some aspects that are discussed controversially. Especially the Reynolds number Re dependence of the propagation behaviour is an open question. This problem was addressed on the basis of experimental investigations of compressible, transient, subcritical, round air jets. For this purpose, the velocity field of sudden horizontal vessel discharges were considered experimentally for the first time with a phase Doppler anemometer in the range of up to 60 times the outlet diameter. The determination of the particle size in addition to the velocity provided an important basis for validation. This ensured that only particles with an almost perfect following behaviour exhibiting the gas velocity were considered. Statistical analyses show a significant influence of the Reynolds number Re on the decay rate K1,u with a significance value p = 1.703 ⋅ 10-4 and spreading rate K2,u with p = 1.453 ⋅ 10-6 in the investigated range of Reynolds number 30 000 ≤ Re ≤ 400 000. With increasing Reynolds number Re, the decay rate increases K1,u and the spreading rate K2,u decreases. This disproves the theory that the propagation of free jets is independent of the Reynolds number Re. Since the influence of the Reynolds number is relatively small, the specification of an average value and a quasi-self-similar behaviour seems to be appropriate. The average decay constant is K1,u = 5.86 and the average spreading rate is K2,u = 0.096.
Direct OC-CHO coupling towards highly C2+ products selective electroreduction over stable Cu0/Cu2+ interface
Authors: Zhang Xin Yu , Lou Zhenxin , Chen Jiacheng , Liu Yuanwei , Wu Xue Feng , Zhao Jia Yue , Yuan Haiyang , Zhu Minghui , Dai Sheng , Wang Haifeng , Sun Chenghua , Liu Peng Fei , Yang Huagui
Published: December 2022

Electroreduction of CO2 to valuable multicarbon (C2+) products is a highly attractive way to utilize and divert emitted CO2. However, a major fraction of C2+ selectivity is confined to less than 90% by the difficulty of coupling C-C bonds efficiently. Herein, we identify the stable Cu0/Cu2+ interfaces derived from copper phosphates-based (CuPO) electrocatalysts, which can facilitate C2+ production with a low-energy pathway of OC-CHO coupling verified by in situ spectra studies and theoretical calculations. The CuPO precatalyst shows a high Faradaic efficiency (FE) of 69.7% towards C2H4 in an H-cell, and exhibits a significant FEC2+ of 90.9% under industrially relevant current density (j = -350 mA cm-2) in a flow cell configuration. The stable Cu0/Cu2+ interface breaks new ground for the structural design of electrocatalysts and the construction of synergistic active sites to improve the activity and selectivity of valuable C2+ products.
A case of traumatic cataract caused by cosmetic laser and literature review
Authors: Li Bingzhen , Zhang Jiaxin , Wang Haikun , Dai Jinyue , Li Xuemin
Published: December 2022

Background
Eye injury is one of the most disastrous complications of laser cosmetic treatment, among them, traumatic cataract is very rare.
Methods
This paper reports a rare case of traumatic cataract with iris injury, hyphema and secondary glaucoma caused by cosmetic laser, and reviews the previous cases of cataract after cosmetic laser.
Results
The trajectory of laser was unexpectedly found in the lens of both eyes, up to 7 months of follow-up showed that the cataract had no significant effect on vision, only photophobia was retained.
Conclusion
The incidence of cosmetic laser-induced cataract may be much higher than currently realized and appropriate eye protection is very important during cosmetic laser treatment.
Emergent Cooperation from Mutual Acknowledgment Exchange in Multi-Agent Reinforcement Learning
Authors: Phan Thomy , Sommer Felix , Ritz Fabian , Altmann Philipp , Nüßlein Jonas , Kölle Michael , Belzner Lenz , Linnhoff-Popien Claudia
Published: December 2022

Peer incentivization (PI) is a recent approach, where all agents learn to reward or to penalize each other in a distributed fashion which often leads to emergent cooperation. Current PI mechanisms implicitly assume a flawless communication channel in order to exchange rewards. These rewards are directly integrated into the learning process without any chance to respond with feedback. Furthermore, most PI approaches rely on global information which limits scalability and applicability to real-world scenarios, where only local information is accessible. In this paper, we propose Mutual Acknowledgment Token Exchange (MATE), a PI approach defined by a two-phase communication protocol to mutually exchange acknowledgment tokens to shape individual rewards. Each agent evaluates the monotonic improvement of its individual situation in order to accept or reject acknowledgment requests from other agents. MATE is completely decentralized and only requires local communication and information. We evaluate MATE in three social dilemma domains. Our results show that MATE is able to achieve and maintain significantly higher levels of cooperation than previous PI approaches. In addition, we evaluate the robustness of MATE in more realistic scenarios, where agents can defect from the protocol and where communication failures can occur. We also evaluate the sensitivity of MATE w.r.t. the choice of token values.
Multi-stable spatial patterns and spatiotemporal staggered periodic patterns in a predator-taxis model with delay
Authors: Xing Yue , Jiang Weihua , Cao Xun
Published: December 2022

The effects of predator-taxis and conversion time delay on formations of spatiotemporal patterns in a predator-prey model are explored. Firstly, the well-posedness, which implies global existence of classical solutions, is proved.Then, we establish critical conditions for the destabilization of coexistence equilibrium through Turing/Turing-Turing bifurcations via describing the first Turing bifurcation curve, and theoretically predict possible bi-stable/multi-stable spatially heterogeneous patterns. Next, we demonstrate that coexistence equilibrium can also be destabilized through Hopf, Hopf-Hopf, Turing-Hopf bifurcations, and possible stable/bi-stable spatially inhomogeneous staggered periodic patterns, bi-stable spatially inhomogeneous synchronous periodic patterns, are theoretically predicted.Finally, numerical experiments also support theoretical predictions and partially extend them. In a word, theoretical analyses indicate that, on the one hand, large predator-taxis can eliminate spatial patterns caused by self-diffusion; on the other hand, the joint effects of predator-taxis and conversion time delay can induce complex survival patterns, e.g., bi-stable spatially heterogeneous staggered/synchronous periodic patterns, thus diversify populations' survival patterns.
Mathematics Subject Classification (2020) 35B32 · 35K57 · 92C15
The Surgical Strategy of Juvenile Nasopharyngeal Angiofibroma: A Case Report
Authors: Liu Shengyang , Yu Liang , Yu Peng , Sun Shujuan , Wang Yuedong , Liu Shanfeng , Shi Li , Wan Yuzhu , Chen Aiping
Published: December 2022

Surgical resection to remove juvenile nasopharyngeal angiofibroma is challenging due to the high risk of massive hemorrhage. We report a comprehensive strategy which included preoperative devascularization by embolizing the feeding arteries and combined endoscopic and transoral approach was adopted.
Mathematical scrutiny of singular predator-prey model with stage-structure of prey
Authors: YADAV UGANTA , Nayak Ameeya Kumar , Gakkhar Sunita
Published: December 2022

In this paper, a stage structured predator-prey model with Holling type II functional response is formulated, considering the juvenile prey as the favorite food for the generalist predator. Further, the existence of predators is ensured by the sufficient amount of alternative food available in the habitat. The proportional harvesting of the adult prey is incorporated with the assumption that only the adult prey are of economic worth. The existence and local stability of the distinct equilibrium points of the system are investigated. The bifurcation from origin to predator free equilibrium state is obtained for the bifurcation parameter-effort on harvesting. The occurrence of Hopf bifurcation about the interior equilibrium state is established for arbitrary model parameters and the supercritical nature of this bifurcation is proved by fixing these parametric values. An algebraic equation is included to this modified model to analyze the economic benefits resulted from the harvesting of adult prey. The singularity-induced bifurcation (SIB) about the coexisting equilibrium state of differential-algebraic system is deduced along the parameter v at v = 0, v being the profit/loss due to harvesting. The state feedback controller is recommended to eliminate the SIB about the coexisting equilibrium state for the differential algebraic system. Adopting an appropriate feedback control would ensure the stability of coexistence interior equilibrium state along with economic profit from harvesting. Numerical examples are used to elaborate the analytical results obtained.
Development and Validation of an Immune-related Gene Diagnostic Model for Cancerous Change in Oral Leukoplakia
Authors: Lin Yang , Gao Bingju , Li Jun , Chen Peng , Qiu Yu
Published: December 2022

Background: Oral squamous cell carcinoma (OSCC) is usually preceded by oral potentially malignant disorders, Such as oral leukoplakia (OLK). The prevention of the transformation of OLK to OSCC may significantly improve clinical outcomes of patients. Recent studies have highlighted the dynamics of immune microenvironment during oral carcinogenesis. Given this context, this study aimed to development an immune-related gene diagnostic model for predicting malignant transformation of OLK to OSCC.Methods: In this study, we first compared immune cell infiltration between the control and OLK and OSCC from two GEO databases (GSE85195 and GSE23558) using CIBERSORT algorithm. Next, we compared differentially expressed genes between the control and OSCC and OLK and OSCC using the LIMMA package. Finally, developed an immune-related gene diagnostic model using the LASSO regression and used the GSE26549 and TCGA databases to validate the model’s predictive ability.Results: The composition of 22 types of immune cells in each sample was presented in a boxplot (figure 1A). The expression of dendritic cells resting, macrophages M0, macrophages M2, and mast cells resting were significantly different between the OLK and OSCC groups (P<0.001).1432and 1256 DEGs were identified from GSE85195 and GSE23558, respectively. Overlapping differential DEGs and the 2483 immune-related genes. Sixty-nine candidate genes were integrated into the LASSO regression to identify OLK cancerous immune signatures. The area under ROC curve (AUC) in the training and internal validation cohorts were 1 and 0.994(figure 4A), respectively. Finally, a model comprising 16 immune signatures was constructed.Conclusions: This study develop and validate an immune-related gene diagnostic model was a promising objective diagnosis scheme to predict cancer risk of OLK to OSCC.