bluuebunny/crossref_metadata_2025 huggingface dataset:
Evidence based clinical practice guidelines for the management of acute ankle injuries according to: PRISMA systematic review and quality appraisal with AGREE II.
Authors: Bsoul Najeeb , Ling Liang , Cai Leyi , Mazmanyan Davit , Porter Daniel
Published: March 2024

Background
Acute ankle injuries are a common injury seen in emergency rooms resulting in huge social impact and sometimes devastating consequences. Several clinical practice guidelines (CPGs) related to ankle injuries have been developed by various organizations, but there is a lack of a critical appraisal of them. The purpose of this systematic review is to find and critically appraise evidence-based clinical practice guidelines for EB-CPGs related to acute ankle injuries in adults.
Method
Cochrane Library, MEDLINE, EMBASE, WHO databases, and 98 worldwide orthopedic association websites were searched until early 2023. Two authors individually employed the inclusion and exclusion criteria, and each EB-CPG was subject to an independent critical appraisal of its content, by four authors, using the Appraisal of Guidelines for REsearch and Evaluation (AGREE II) instrument, and AGREE II scores for each domain were calculated.
Results
Five evidence-based clinical practice guidelines were included in this review. Mean scores for all six domains were as follows: Scope and Purpose (87.8%), Stakeholder Involvement (69.2%), Rigour of Development (72.5%), Clarity of Presentation (86.9%), Applicability (45.6%), and Editorial Independence (53.3%).
Conclusion
The overall quality of the existing ankle injuries EB-CPGs is not strong and three of them are out of date. Useful guidance related to Ottawa rules, manual therapy, cryotherapy, functional supports, early ambulation, and rehabilitation have been mentioned. monitoring and/or auditing criteria, the view and preferences of the target population item, and editorial independence are challenge areas and future guidelines should focus on improvements in these domains.
Systematic Review: Systematic review.
Micro-CT, mechanical, and histological examination of the effect of local adjuvants on porcine cortical bone following intralesional curettage of bone tumors
Authors: Apostolopoulos Vasileios , Boháč Petr , Marcián Petr , Zambo Iva Staniczková , Pazourek Lukáš , Mahdal Michal , Neradil Assoc. Prof. RNDr. Jakub , Návrat Assoc. Prof. Ing. Tomáš , T Assoc. Prof. MUDr. Tomáš
Published: March 2024

Background and Objectives
Curettage is the removal of a tumor from the bone while preserving the surrounding healthy cortical bone and is associated with higher rates of local recurrence. To lower those rates, curettage should be combined with local adjuvants. Although, their use is associated with damage to nearby healthy bone. The purpose of this analysis is to determine the effect of local adjuvants on cortical porcine bone by using micro computed tomography (micro-CT), along with histological and mechanical examination.
Methods
Local adjuvants were applied to porcine specimens under defined conditions. To assess changes in bone mineral density (BMD), a micro-CT scan was used. The pixel gray values of the volume of interest (VOI) were evaluated per specimen and converted to BMD values. The Vickers hardness test was employed to assess bone hardness (HV). The depth of necrosis was measured histologically using hematoxylin-eosin-stained tissue sections.
Results
A noticeable change of BMD was observed on argon beam coagulation (ABC) sample. Comparable hardness values were measured on samples following electrocautery and ABC. Lowering of bone hardness was obtained in the case of liquid nitrogen. Extensive induced depth of necrosis was registered in the specimen treated with liquid nitrogen.
Conclusion
The study determined the effect of local adjuvants on cortical bone by using micro-CT, histological, and mechanical examination. Phenolization and liquid nitrogen application caused a decrease in bone hardness. The bone density was affected in the range of single-digit percentage. Liquid nitrogen induced extensive depth of necrosis with a wide variance of values.
Length of hospital stay and associated treatment costs for patients with susceptible and antibiotic-resistant Salmonella infections: systematic review and meta-analysis
Authors: Kim Chaelin , Frost Isabel , Naylor Nichola R. , Au Heidi , Lee Yubin , Bzymek Anna , Majgier Kamila , Moldoveanu Ana Laura , Salman Omar Mukhtar , Simiyu Shillah , Youssef Dina Mohamed , Hasso-Agopsowicz Mateusz , Abbas Kaja
Published: March 2024

Background
The global disease burden of Salmonella infections in 2017 included 135,900 deaths caused by Salmonella Typhi and Paratyphi and 77,000 deaths caused by invasive non-typhoidal Salmonella, and increasing antimicrobial resistance further exacerbates morbidity, mortality, and costs. To address the evidence gap on the economic burden of antimicrobial resistant Salmonella infections, our study aim is to estimate the estimate the length of hospital stay and associated treatment costs for patients with susceptible or antibiotic-resistant Salmonella Typhi, Paratyphi, and non-typhoidal Salmonella infections.
Methods
We conducted a systematic review by searching EMBASE, Medline, Scopus, Hinari, and LILACS databases for studies published between January 1, 2005 and December 17, 2021, with no language restrictions. We identified studies that reported on length of hospital stay and associated treatment costs for patients with susceptible or antibiotic-resistant Salmonella Typhi, Paratyphi, and non-typhoidal Salmonella infections. We converted monetary costs to 2019 USD and pooled estimates by quantile level of GDP per capita using random effects meta-analysis. We assessed the quality of included studies using critical appraisal tools from the Joanna Briggs Institute.
Results
We included 26 studies in our systematic review, and the mean quality scores ranged from 0.55 to 1.00 across different study designs. Patients with drug-resistant Salmonella infections had significantly longer hospital stays, with an additional 0.5–2.2 days compared to drug-susceptible Salmonella infections. The direct hospitalisation costs for drug-resistant typhoidal Salmonella were 71–103% higher than for drug-susceptible typhoidal Salmonella infections in the same setting. The mean hospital stay was 5.9 days (95% CI: 4.4, 7.5) for drug-susceptible typhoidal Salmonella infections, while it was 7 days (95% CI: 4.7, 9.3) for resistant typhoidal Salmonella infections in the lowest income quintile.
Conclusions
While the length of hospital stay and associated treatment costs for patients with antibiotic-resistant Salmonella infections varied by pathogen, country, and resistance level, they were higher in comparison to antibiotic-susceptible Salmonella infections. However, evidence on length of hospital stay and treatment costs are lacking from typhoid-endemic regions of sub-Saharan Africa.
Emotional Stimulus Processing in Depression: Insights from the Investigation of Symptom-Specific Alterations of the Late Positive Potential
Authors: Mura Francesca , Patron Elisabetta , Catrambone Vincenzo , valenza Gaetano , Gentili Claudio
Published: March 2024

Depression is associated with altered processing of emotional stimuli, often detected by changes in late positive potential (LPP) features. However, evidence on LPP amplitude and latency in individuals with depressive symptoms shows inconsistencies. These may stem from the heterogeneity inherent to depressive conditions, which were primarily investigated in terms of symptoms severity. Somatic and cognitive-affective symptoms, to our knowledge, have not been properly accounted for. 66 individuals with absent to severe depressive symptoms were presented with emotional pictures (pleasant, neutral, and unpleasant) while the electroencephalographic signal was recorded from a 32-channel cap. Linear mixed models were performed on LPP's mean amplitude and fractional peak latency adding fixed effects of emotional condition, severity of somatic and cognitive-affective depressive symptoms, and their interactions. Random effects included subject and channel factors. Our findings show a differential effect of somatic and cognitive-affective depressive symptoms on LPP amplitude and latency. Higher cognitive-affective symptoms were associated with reduced LPP amplitude for both pleasant (b = − .53, p < .001) and unpleasant (b = − .24, p = .007) pictures, while higher somatic symptoms were linked to an increased LPP amplitude for pleasant (b = .19, p = .030) and unpleasant (b = .31, p < .001) stimuli. Shorter LPP latencies were associated with higher somatic depressive symptoms, specifically for neutral pictures (b = -25.33, p = .007). These findings suggest a differential impact of somatic and cognitive depressive symptoms on central indices reflecting the elaboration of emotional stimuli. Therefore, we argue that a comprehensive understanding of the mechanisms governing emotional processing in depressive subjects should consider the specificity of individual symptoms.
VReiraum – ein interdisziplinärer Makerspace für die Entwicklung von VR-/AR- Lernszenarien
Authors: Prote Lisann , Tschiersch Anja , Brendel Nina
Published: March 2024

Die wachsende Bedeutung von VR-/AR-Technologien im unterrichtlichen Kontext (z. B. in Fächern wie Geografie, Chemie, Geschichte, Mathematik, Musik oder Informatik) erfordert eine entsprechende Ausbildung angehender Lehrkräfte, um entsprechende Lernszenarien im Unterricht zielgerichtet einsetzen und die Potenziale dieser Lernmedien ausschöpfen zu können. Welche Kompetenzen dafür erforderlich sind und inwiefern dies (fächerübergreifend) in der Hochschullehre gelingen kann, wurde in dem Projekt VReiraum qualitativ mithilfe explorativer Forschungsmethoden untersucht. Das zentrale Element des Projekts stellte der interdisziplinäre Makerspace dar, eine neuartige Form der fächerübergreifenden Hochschullehre, die Ressourcen teilt, Kompetenzen der einzelnen Fächer für alle nutzbar macht und übergreifende fachliche und methodische Hilfestellungen anbietet. Nach dem ersten Durchlauf des Projekts, welches von der Stiftung Innovation in der Hochschullehre gefördert wurde, wurde der Makerspace angepasst und neu strukturiert. Erste Erkenntnisse lagen darin, dass eine Vernetzung der sechs involvierten Fächer nur gelingen kann, wenn eine gewisse Vorstrukturierung der möglichen Schnittstellen zur Nutzung des Makerspace von den Dozierenden erfolgt. Auf diese Weise kann in Zukunft besser auf die Expertise der verschiedenen Fächer zurückgegriffen werden. Als gewinnbringend stellte sich die Erprobung und Evaluation der (selbst entwickelten) VR-/AR- Lernumgebungen in der Schule heraus, die auch im zweiten Durchgang des Projekts Bestandteile einiger Lehrveranstaltungen im Sommersemester 2023 blieben.
CHARACTERISTICS OF STORIES AND IMAGES IN THE QURAN
Authors: Putri Endrika Widdia
Published: March 2024

This research explores the characteristics of stories and parables in the Quran. This research is qualitative research using exploratory and analytical methods. The results found regarding the characteristics of the story in the Quran, namely; arranged in themes, has a purpose and is substantially religious; not arranged sequentially and not at length; several stories are told repeatedly which vary. While the characteristics of parables in the Quran, namely; explanation of abstract meaning; the parallels between the conditions of the parable referred to and their equivalents; a balance between the parable and the analogous state.
COMPARATIVE STORY OF THE SLAUGHTER OF ABRAHAM’S SON IN THE QURAN AND THE BIBLE
Authors: Rahmanto Oki Dwi
Published: March 2024

The story of the slaughter of Abraham's son has attracted a lot of attention among Muslims and non-Muslims. This is because there are different views in the Koran and the Bible regarding who was the figure behind Abraham's slaughter of his son. This research is included in the research library study or literature review. The method taken is descriptive-analysis with a comparative approach between the two books. To produce specific and detailed data, the researcher presents two interpreters in the Koran and the Bible, namely Quraish Shihab as an interpreter of the Koran and Matthew Henry as an interpreter of the Bible. The findings were based on research, namely the first male figure who was slaughtered in the Quran according to the viewpoint of Quraish shihab, namely Ismail. Meanwhile, according to Matthew Henry, that is Isaac. The two factors that cause the difference in interpretation are that the Quraish Shihab in its literature refers to the interpretation of Tabataba'i, which refers to ismail. Apart from that, Quraish Shihab also performed inter-verse munasbahs related to the slaughter of Abraham for his son, while Matthew Henry interpreted the editors in the Bible in a textual way who stated that it was Isaac who was slain. The third impact of interpretation on Muslims and non-Muslims is how they take lessons from the story regarding the meaning of patience, obedience and sincerity.

Keywords: Abraham, Slaughter, Al Qur'an and the Bible
THE ANALYSIS OF GUS BAHA'S HADITH STUDY ON YOUTUBE: ARBA'IN NAWAWI CHAPTER OF NIAT
Authors: Rohman Ali Abdur , Noorhidayati Salamah
Published: March 2024

Kajian agama yang awalnya disampaikan secara langsung di mana antara Kyai dan santri berada dalam satu majlis, karena perkembangan teknologi pengajian tersebut dapat direkam dan ditayangkan ulang melalui berbagai media sosial salah satunya YouTube. Penelitian ini dilakukan bertujuan untuk mendeskripsikan dan menganalisis salah satu kajian Hadis yang tayang di YouTube oleh Gus Baha’ dengan materi hadits Arba’in Nawawi pada bab niat. Penelitian ini bersifat etnografi virtual, yang mana data diambil dari kanal YouTube yaitu “Tafsir NU” dan  “Islamic Studies With Gus Baha’’. Rumusan masalah dalam penelitian ini meliputi bagaimana teknis pengajian hadis Gus Baha’ dan isi yang terkandung dalam kajian Gus Baha’ terhadap hadis tentang niat. Temuan dalam penelitian ini, pertama Gus Baha’ dalam penyajiannya menggunakan metode bandongan yang dalam penyampaiannya menggunakan bahasa Jawa Pegon sebagaimana tradisi pesantren salaf. Kedua, materi penjelasannya meliputi unsur fikih, sejarah, pemikiran dan qaul sahabat, kontekstualisasi makna hijrah, ajaran tasawuf yang meliputi: kontekstualisasi makna zuhud, ikhlas dan aktualisasi konsep tawadhu’.
MASSA TETES AIR HUJAN DALAM ALQURAN (Analisis Ilmiah QS. Az-Zukhruf Ayat 11)
Authors: Septinawati Rizky dwi Ratna
Published: March 2024

This research particularly examines the meaning of "بقدر" in QS. Az-Zukhruf verse 11 by applying the science of climatology to rainwater levels. This study aims to provide new knowledge regarding the meaning of levels in QS. Az-Zukhruf verse 11. The phenomenon of rain falling to the earth is a natural process and we often feel. The phenomenon of rainwater falling to the earth has a level that has been determined by Allah in the Qur'an to be a mercy, but we often encounter natural disasters caused by the presence of rainwater that falls beyond the capacity of water reservoirs on earth. Thus, to reveal the meaning of the level of rainwater, it takes the discipline of Climatology as an analytical approach. Along with this study, the author applies the Science of Climatology to reveal the calculation of levels in QS. Az-Zukhruf verse 11.This research is a literature study (Library Research) using qualitative research methods, by collecting several paperwork from commentators and scientific scientific journals. The primary data used in this study is the Qur'an QS. Az-Zukhruf verse 11 and books on climatology.The results of the research on the mass of raindrops in Al-Qur’an by implementing the discipline of Climatology are to reveal the meaning of rainwater content in QS. Az-Zukhruf verse 11 and the results of the calculation of the mass of raindrops in the Quran.
Citizen science in studying the microplastic pollution of the Russian Arctic
Authors: Ershova A. A. , Smolokurov A. V.
Published: March 2024

Abstract The article presents a long-term study (2020–2022) on microplastic pollution in the seas of the Russian Arctic using the citizen science method. Methodological approaches to sample collection and their laboratory processing for isolating microplastic particles from environmental samples are presented, as well as some results of studying the role of the North Cape Current in microplastics transfer from the North Atlantic region to the Russian part of the Barents Sea. The joint cooperation between public organizations and scientific institutes is shown to be effective in providing science-based methodological approaches to volunteers conducting research in hard-toreach regions of the Arctic. The published guidelines and educational materials are publicly available to everyone interested in using them in future research.
Differentiation of general education quality in single-industry Arctic towns as assessed by educational participants
Authors: Punantsev A. A.
Published: March 2024

Arctic territories, whose development is clearly focal in nature, are characterized by a higher proportion of single-industry towns in the total number of municipal divisions as compared to the national average. The uneven development of areas dominated by individual monopsonists manifests itself in different spheres, including the education system. The article summarizes the results of studying the quality differentiation of general education in single-industry Arctic towns. In this study, the author analyzed the results of a questionnaire survey carried out among the parents of students in general education institutions located in seven Arctic regions of the Russian Federation. Through comparison of the received responses, the author identified areas that distinguish the situation with education quality distribution in single-industry towns of the Russian Arctic from other territories of this macroregion.
DETERMINAÇÃO E DISTRIBUIÇÃO DE Cu, Fe E Zn EM CAMAPU POR ICP-OES
Authors: Pereira Cecilia , Lemos Michelle , Dantas Kelly
Published: March 2024

DETERMINATION AND DISTRIBUTION OF Cu, Fe, AND Zn IN CAMAPU BY ICP-OES. This study aimed to determine the total contents of copper, iron, and zinc in camapu and protein fractions by inductively coupled plasma emission spectrometry. Firstly, lipid removal was performed using chloroform and methanol (2:1). Protein fractions were obtained after sequential extraction using four extractors (water, 0.5 mol L-1 sodium chloride, 50% acetic acid v v-1 and 0.05 mol L-1 sodium hydroxide). The camapu sample and protein fractions were digested in a cavity-microwave oven with diluted nitric acid and hydrogen peroxide. The accuracy of the procedure was evaluated using the addition and recovery method in the digests and protein extracts. All the elements were determined in the protein fractions. Levels of Cu, Fe, and Zn ranged from 0.07 to 0.5 mg kg-1 were found in the lipid fraction. The residue presented higher iron content compared to other elements. Higher Cu and Zn contents were found associated with albumin. All elements studied were found in the protein fractions, and the total protein concentration determined in each protein fraction was 5.74 mg kg-1 (albumins), 0.28 mg kg-1 (globulins), 4.46 mg kg-1 (glutelins 1) and 0.46 mg kg-1 (glutelins 2).
Self-Management Competence in University Students: Essence and Structure
Authors: Chernyh Natal'ya , Osipova Svetlana
Published: March 2024

Versatile young specialists are currently in great demand. To be a high-achiever, a successful professional needs the so-called supra-professional skills, which are responsible for personal development. To manage their own study, work, and life, university students require good self-management skills, e.g., setting goals, meeting deadlines, scheduling, road mapping, self-education, reflection, self-correction, etc. Self-management is an object of personal education and an important element of personal development in university environment. This article describes the essence and content of self-management as a competence acquired at university. A review of scientific literature made it possible to prove the relevance of self-management as part of university education. Self-management appeared to have four components, i.e., 1) motivation and target, 2) cognition, 3) activity, 4) reflection and evaluation, while its structure consisted of three development levels, i.e., initial, basic, and advanced.
Scientific and Methodological Support of Teachers as a Tool for Developing Professional and Personal Competencies in Advanced Professional Education
Authors: Geynce Larisa
Published: March 2024

Life-long learning is compulsory in the modern teaching community. School teachers need scientific and methodological support for their professional and personal development, especially as part of advanced professional education. A tailored academic program uses various techniques and methods to fill in gaps in one’s professional competencies. The author analyzed the structure of scientific and methodological support for the professional and personal development of schoolteachers based on personalized and personality-oriented approaches, e.g., such methods as supervision, coaching, and mentoring. The article introduces the concept of scientific and methodological support of schoolteachers as an integral system of interrelated actions and areas of work focused on the professional and personal development. Some elements of the scientific and methodological support system were tested at a series of practical webinars with students of a pedagogical university and schoolteachers.
Hydro-meteorological response to climate change impact in Ethiopia: a review
Authors: Chanie Kassaw Muluye
Published: March 2024

Climate change poses significant challenges to water resources and streamflow in Ethiopia, a country highly dependent on agriculture and vulnerable to environmental shifts. This paper reviews the current state of knowledge on climate change impacts on streamflow in Ethiopia, emphasizing factors driving these changes and drawing insights from relevant studies. The analysis encompasses hydrological responses to climate change, including alterations in precipitation patterns, temperature fluctuations, and changes in water availability. Additionally, the study examines the impact of land use changes on streamflow dynamics. Comparative insights from neighboring countries and river basins further illuminate the broader regional implications of climate change on water resources. According to the previous research reviewed in this paper, climate change, land use change, and increment in extreme events (drought) have affected the stream flow over the last decades. The findings underscore the urgent need for adaptive strategies and sustainable water management practices to mitigate the adverse effects of climate change on streamflow and ensure water security in Ethiopia and beyond.
A review of microplastics in wastewater treatment plants in Türkiye: Characteristics, removal efficiency, mitigation strategies for microplastic pollution and future perspective
Authors: Acarer Arat Seren
Published: March 2024

The effluent of WWTPs is an important source of microplastics (MP) for the aquatic environment. In this review study, MPs in wastewater treatment plants (WWTP) in Türkiye and their removal from WWTPs are reviewed for the first time. First, MP characteristics in the influent and effluent of WWTPs in Türkiye are discussed. In the next section, the abundance of MPs in the influent and effluent of WWTPs in Türkiye and the MP removal efficiency of WWTPs in Türkiye are evaluated. Then, the results of studies on MP abundance and characteristics in Türkiye's aquatic environments are presented and suggestions are made to reduce MPs released from WWTPs into the receiving environments. Strategies for reducing MPs released to the receiving environment from WWTPs of Türkiye are summarized. In the last section, research gaps regarding MPs in WWTPs in Türkiye are identified and suggestions are made for future studies. This review paper provides a comprehensive assessment of the abundance, dominant characteristics, and removal of MPs in WWTPs in Türkiye, as well as the current status and deficiencies in Türkiye. Therefore, this review can serve as a scientific guide to improve the MP removal efficiency of WWTPs in Türkiye.
Compounds based on Adamantyl-substituted Amino Acids and Peptides as Potential
Antiviral Drugs Acting as Viroporin Inhibitors
Authors: Garaev Timur M. , Grebennikova Tatyana V. , Lebedeva Varvara V. , Avdeeva Varvara V. , Larichev Viktor F.
Published: March 2024

The discussion has revolved around the derivatives of amino acids and peptides containing carbocycles
and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus.
Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to
hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent
virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles. A conceptual framework
for viroporin inhibitors has been introduced, incorporating carbocyclic motifs as membranotropic carriers in
the structure, alongside a functional segment comprised of amino acids and peptides. These components correspond
to the interaction with the inner surface of the channel's pore or another target protein.
Network Pharmacology along with Molecular Docking to Explore the Mechanism of
Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome
Validation
Authors: Dai Quankai , Pan Yijun , Zhu Xiwen , Chen Mengyao , Xie Lin , Zhu Yu , Wan Guoxing
Published: March 2024

Introduction:

Although anthracyclines have demonstrated efficacy in cancer therapy, their utilization
is constrained by cardiotoxicity. In contrast, Danshen injection (DSI), derived from Salvia miltiorrhiza,
has a longstanding tradition of being employed to ameliorate cardiovascular ailments, including anthracycline-
induced cardiotoxicity (AIC). Nonetheless, there is a notable dearth of comprehensive systematic investigation
into the molecular mechanisms underlying DSI's effects on AIC. Consequently, this study was undertaken
to explore the underlying mechanism by which DSI acted against AIC.

Methods:

Employing network pharmacology approach, the current investigation undertook a comprehensive
analysis of the impact of DSI on AIC, which was further validated by transcriptome sequencing with in vitro
AIC model. Additionally, molecular docking was conducted to evaluate the binding of active ingredients to
core targets. A total of 3,404 AIC-related targets and 12 active ingredients in DSI, including chrysophanol,
luteolin, tanshinone IIA, isoimperatorin, among others, were collected by differentially expressed analysis and
database search, respectively.

Results:

The network pharmacology and enrichment analysis suggested 102 potential targets and 29 signaling
pathways associated with the protective effect of DSI on AIC. Three core targets (CA12, NOS3, and POLH)
and calcium signaling pathways were further validated by transcriptomic analysis of the in-vitro model. The
high affinity of the active ingredients binding to corresponding targets was confirmed by molecular docking.

Conclusion:

The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition
of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are
warranted to verify the findings.
Specific Targeting of Zinc Transporter LIV-1 with Immunocytokine
Containing Anti-LIV-1 VHH and Human IL-2 and Evaluation of its In vitro
Antitumor Activity
Authors: Dehghan Rada , Parikhani Arezoo Beig , Cohan Reza Ahangari , Shokrgozar Mohammad Ali , Mirabzadeh Esmat , Ajdary Soheila , Zeinali Sirous , Ghaderi Hajarossadat , Talebkhan Yeganeh , Behdani Mahdi
Published: March 2024

Background:

Interleukin 2 (IL-2) is a vital cytokine in the induction of T and NK cell responses,
the proliferation of CD8+ T cells, and the effective treatment of human cancers, such as melanoma and renal
cell carcinoma. However, widespread use of this cytokine is limited due to its short half-life, severe toxicity,
lack of specific tumor targeting, and activation of Treg cells mediated by high-affinity interleukin-2 receptors.

Objective:

In this study, a tumor-targeting LIV-1 VHH-mutIL2 immunocytokine with reduced CD25 (α chain
of the high-affinity IL-2 receptor) binding activity was developed to improve IL-2 half-life by decreasing its renal infiltration in comparison with wild and mutant IL-2 molecules.

Methods:

The recombinant immunocytokine was designed and expressed. the biological activity of the purified fusion protein was investigated in in vitro and in vivo experiments

Results:

The fusion protein represented specific binding to MCF7 (the breast cancer cell line) and more efficient cytotoxicity than wild-type IL-2 and mutant IL-2. the PK parameters of the recombinant immunocytokine were also improved in comparison to the IL-2 molecules.

Conclusion:

The observed results showed that LIV1-mIL2 immunocytokine could be considered an effective
agent in the LIV-1-targeted treatment of cancers due to its longer half-life and stronger cytotoxicity.
Advancing Breast Cancer Drug Delivery: The Transformative Potential of
Bioinformatics and Artificial Intelligence
Authors: Singh Dilpreet , Sachdeva Diksha , Singh Lovedeep
Published: March 2024

Breast cancer remains a significant global health challenge, necessitating innovative approaches
to improve treatment efficacy while minimizing side effects. This review explores the promising
advancements in breast cancer drug delivery driven by the transformative potential of bioinformatics
and Artificial Intelligence (AI). Bioinformatics plays a pivotal role in unraveling the intricate
genomic landscape of breast cancer, enabling the identification of potential drug targets and biomarkers.
The integration of multi-omics data facilitates a comprehensive understanding of the disease,
guiding personalized treatment strategies. Moreover, bioinformatics-driven approaches aid in
biomarker discovery and prediction, offering novel tools for prognosis and treatment response assessment.
AI, particularly machine learning and deep learning, has revolutionized breast cancer research.
Machine learning models empower accurate diagnosis through image analysis, improve survival
prediction, and enhance risk assessment. Deep learning algorithms, such as convolutional neural
networks, enable precise tumor detection and classification from medical imaging data, notably
mammograms and MRI scans. Additionally, natural language processing techniques facilitate the
mining of vast scientific literature, uncovering hidden insights and identifying potential drug targets.
Network-based approaches integrated with AI algorithms facilitate the identification of central proteins
as promising drug targets within complex biological networks. This review also examines AIoptimized
nanoformulations designed to enhance targeted drug delivery. AI-guided design of drugloaded
nanoparticles improves drug encapsulation efficiency, release kinetics, and site-specific delivery,
offering promising solutions to overcome the challenges of conventional drug delivery.
Investigating the Effects of Dorema hyrcanum Root Extracts on Selective Induction of
Programmed Cell Death in Glioblastoma, Ovarian Cancer and Breast Cancer Cell
Lines
Authors: Shandi Mahsa Hatami , Sahranavard Shamim , Bagheri Fereshteh , Shahsavari Zahra , Salami Siamak
Published: March 2024

Background:

Despite remarkable advances, cancer has remained the second cause of death, which
shows that more potent novel compounds should be found. Ethnobotanical compounds have a long history of
treating diseases, and several approved chemotherapeutic compounds were isolated from plants.

Objective:

The research aimed to evaluate the cytotoxic effects of Dorema hyrcanum root extract on ovarian,
breast, and glioblastoma cells while examining its selectivity towards normal cells. Additionally, the study is
directed to investigate cell death mechanisms, delineate modes of cell death, and explore intracellular ROS production.

Methods:

Cytotoxic effects of alcoholic, dichloromethane, and petroleum ether fractions of Dorema hyrcanum
were investigated on cancer and normal cells by using MTT assay, and the concentration around IC50 values was
used for flow cytometric assessment of apoptosis, evaluation of the expression of selected genes via RT-qPCR
and production of ROS.

Results:

Methanolic extract exhibited the highest cytotoxicity, impacting A2780CP and MDA-MB-231. All fractions
showed comparable effects on U251 cells. Notably, extracts displayed higher IC50 values in normal HDF
cells, indicating cancer cell specificity. Flow cytometry revealed induction of apoptosis and non-apoptotic death
in all three cancer cell lines. QPCR results showed upregulation of related genes, with RIP3K prominently increased
in U251 glioblastoma. The DCFH-DA assay demonstrated ROS induction by the PE fraction exclusively
in A2780CP cells after 30 minutes and up to 24 hours.

Conclusion:

Dorema hyrcanum root extracts exhibited potent anti-tumor effects against all studied cell lines. The
methanolic extract demonstrated the highest cytotoxicity, particularly against A2780CP and MDA-MB-231 cells.
Importantly, all fractions displayed selectivity for cancer cells over normal HDF cells. Unique modes of action
were observed, with the petroleum ether fraction inducing significant non-apoptotic cell death. These findings
suggest promising therapeutic potential for Dorema hyrcanum in cancer treatment with subject to further mechanistic
studies.
Observando ecologicamente a sociedade moderna
Authors: Figueiredo Nunes de Souza Matheus
Published: March 2024

O presente artigo propõe uma descrição sociológica do que é sustentabilidade, a fim de empregá-la como ferramenta para uma observação ecológica da sociedade moderna. Assim sendo, o objetivo da pesquisa é analisar como as estruturas da sociedade moderna podem ter maior responsividade às demandas ecológicas. Para cumprir com este proposto, o problema de pesquisa que se partiu foi: como é possível operacionalizar a complexidade ecológica nos sistemas sociais, em condições de fechamento operativo? O método de pesquisa do qual se partiu foi a análise funcional, que consiste em levar em consideração as soluções funcionais equivalentes em relação ao problema analisado. As técnicas de pesquisa empregadas foram a revisão de literatura, selecionada, respectivamente, pelos critérios de relevância, acessibilidade e atualidade; e categorias e conceitos operacionais. É possível observar a ausência de um conceito apto a lidar com a complexidade das questões ecológica nos sistemas sociais, o qual pode ser começar a ser estruturado a partir do conceito aqui proposto, tendo em vista sua generalização para ser aplicado em termos de sistemas sociais.
Incidencia de daño en follaje causado por crisomélidos en genotipos de batata en zonas del Caribe húmedo y seco colombiano
Authors: Sierra Janeth Alexandra , Rodríguez María del Valle , Martínez Remberto Rafael , Espitia Laura Beatriz , Pérez José Luis , Araujo Hernando Alberto
Published: March 2024

Para el cultivo de batata se han reportado como plagas a los crisomélidos que se alimentan del follaje disminuyendo la capacidad fotosintética de la planta y por tanto la acumulación de sustancias de reserva en raíces del tubérculo. En Colombia, el cultivo de batata se está impulsando como una alternativa de diversi cación de los sistemas de producción actuales, por lo cual es un cultivo que requiere un mayor conocimiento sobre todo en el área sanitaria. Es por esto que Corpoica viene trabajando en el reconocimiento de plagas potenciales del cultivo
Cardiac Rehabilitation During the COVID-19 Pandemic and the Potential for Digital Technology to Support Physical Activity Maintenance: Qualitative Study
Authors: Park Linda G , Chi Serena , Pitsenbarger Susan , Johnson Julene K , Shah Amit J , Elnaggar Abdelaziz , von Oppenfeld Julia , Cho Evan , Harzand Arash , Whooley Mary A
Published: March 2024

Background

Social distancing from the COVID-19 pandemic may have decreased engagement in cardiac rehabilitation (CR) and may have had possible consequences on post-CR exercise maintenance. The increased use of technology as an adaptation may benefit post-CR participants via wearables and social media. Thus, we sought to explore the possible relationships of both the pandemic and technology on post-CR exercise maintenance.

Objective

This study aimed to (1) understand CR participation during the COVID-19 pandemic, (2) identify perceived barriers and facilitators to physical activity after CR completion, and (3) assess willingness to use technology and social media to support physical activity needs among older adults with cardiovascular disease.

Methods

We recruited participants aged 55 years and older in 3 different CR programs offered at both public and private hospitals in Northern California. We conducted individual interviews on CR experiences, physical activity, and potential for using technology. We used thematic analysis to synthesize the data.

Results

In total, 22 participants (n=9, 41% female participants; mean age 73, SD 8 years) completed in-depth interviews. Themes from participants’ feedback included the following: (1) anxiety and frustration about the wait for CR caused by COVID-19 conditions, (2) positive and safe participant experience once in CR during the pandemic, (3) greater attention needed to patients after completion of CR, (4) notable demand for technology during the pandemic and after completion of CR, and (5) social media networking during the CR program considered valuable if training is provided.

Conclusions

Individuals who completed CR identified shared concerns about continuing physical activity despite having positive experiences during the CR program. There were significant challenges during the pandemic and heightened concerns for safety and health. The idea of providing support by leveraging digital technology (wearable devices and social media for social support) resonated as a potential solution to help bridge the gap from CR to more independent physical activity. More attention is needed to help individuals experience a tailored and safe transition to home to maintain physical activity among those who complete CR.
Economic issues of treating patients with stage 5D chronic kidney disease by dialysis methods of renal replacement therapy in Ukraine: a single-center study
Authors: Shymova А.Yu. , Shifris I.M. , Krasiuk Е.K.
Published: March 2024

Background. The aim of the work was to determine the cost of treating patients with stage 5D chronic kidney disease (CKD) by dialysis methods of renal replacement therapy (RRT) in 2023 based on the analysis of the costs of using hemodialysis (HD) and peritoneal dialysis (PD) in one medical institution. Materials and methods. An open single-center study was conducted at the Кyiv City Center of Nephrology and Dialysis. During 2023, 779 patients with stage 5D chronic kidney disease received renal replacement therapy by dialysis methods in this institution. Among them, 718 participants were treated by hemodialysis and 61 patients by peritoneal dialysis (36 by continuous ambulatory peritoneal dialysis (CAPD) and 25 by automated peritoneal dialysis (APD)). Direct medical and non-medical costs were included in the calculation of the cost of treating chronic kidney disease patients using both dialysis methods. The estimate of the cost of treatment for one patient during the year was calculated according to the formula: when using hemodialysis/hemodiafiltration (HDF) method — the cost of 1 session × 156 sessions, in case of CAPD/APD — the cost of 1 treatment day × 365 days. Results. The analysis of the costs for the treatment of patients with stage 5D CKD allowed us to state that the average cost of one HD/HDF session in 2023 was 3,626.20 UAH, one day of CAPD and APD treatment was 1,539.78 and 1,829.12 UAH, respectively. The average cost of treatment of one patient by HD/HDF method during 2023 was 565,687.20 UAH, CAPD — 562,019.70 UAH, APD — 667,628.80 UAH. In the structure of the cost of treatment, regardless of the modality of RRT, the most expensive component is the cost of consumables. State reimbursement under the Program of Medical Guarantees in 2023 for the treatment of one patient with stage 5D CKD during the year was 385,788 UAH when using GD/GDF, 412,085 UAH for CAPD, 662,110 UAH for APD. That is, based on the data we received, the Program of Medical Guarantees covers only 68.2 % of the costs of medical institution for the treatment with HD/HDF, 73.3 % for the treatment with CAPD and almost 100 % for the treatment with APD. Conclusions. The real cost of treating patients with stage 5D CKD using dialysis methods of RRT is higher than the rate of state reimbursement. The Program of Medical Guarantees doesn’t fully cover the costs of medical institutions for the treatment of patients with stage 5D CKD using RRT methods. CAPD has indisputable advantages in terms of both medical and economic benefit. In addition, the advantage of using CAPD over other dialysis modalities during the war is the absence of dependence on water and electricity supply, the number and workload of medical personnel, the need for patients to constantly visit the dialysis center.
Pemantauan dan Pengendalian Parameter Greenhouse Berbasis IoT Dengan Protokol MQTT
Authors: Eni Dwi Wardihani  , Eka Ulia Sari  , Helmy  , Ari Sriyanto Nugroho  , Yusnan Badruzzaman  , Arif Nursyahid  , Thomas Agung Setyawan  , Media Fitri Isma Nugraha
Published: March 2024

Modernisasi pada sektor pertanian diharapkan berpengaruh pada peningkatan kualitas, jumlah produksi, dan kontinuitas suplai hasil tani. Saat ini banyak dikembangkan pertanian cerdas (smart agriculture) dalam greenhouse. Namun, beberapa parameter greenhouse harus diperhatikan supaya pertumbuhan tanaman berlangsung secara optimal. Pada penelitian ini dibuat sebuah sistem pemantauan dan pengendalian beberapa parameter greenhouse berbasis internet of things (IoT) yang memungkinkan petani melakukan pemantauan dan pengendalian kapan pun dan di mana pun. Hal ini juga dapat meningkatkan efisiensi kerja petani dalam melakukan pemantauan dan pengendalian, terlebih jika greenhouse yang dipantau dan dikendalikan lebih dari satu. Data-data hasil pemantauan greenhouse dapat dilihat secara real-time dan tersimpan di server, sehingga memudahkan petani melakukan evaluasi terhadap greenhouse dan tanaman. Beberapa parameter yang dipantau adalah suhu greenhouse, kelembapan greenhouse, dan intensitas cahaya dalam greenhouse, sedangkan parameter yang dikendalikan adalah suhu greenhouse dan kelembapan greenhouse, dengan menggunakan exhaust fan. Proses pengiriman data pemantauan dan pengendalian parameter greenhouse dilakukan menggunakan protokol message queue telemetry transport (MQTT). Pengujian data loss dan delay pada sistem diperlukan untuk mengetahui keandalan alat dalam proses pengiriman dan penerimaan data. Hasil pengujian quality of service (QoS) adalah sebagai berikut: rata-rata data loss pemantauan Gateway-Server sebesar 10,6 %, rata-rata delay pemantauan gateway-server sebesar 1,9 s, dan rata-rata delay pengendalian server-gateway sebesar 7,1 s. Saat nilai parameter suhu greenhouse kurang dari batas ambang maksimal yang ditentukan, sistem akan menyalakan drum fan agar suhu mencapai nilai minimal pada batas ambang.
Benevolence or Pretext: An Exploration of U.S. Foreign Policy Toward China in the Early 20th Century from the Perspective of Social Darwinism
Authors: Zhang Xiaoxi
Published: March 2024

Applying Darwin’s principles of natural selection and survival of the fittest to human society, social Darwinists in the late nineteenth century proposed the Manifest Destiny of the Anglo-Saxon race. Based on the social Darwinism theory, this paper looks into the United States overseas expansion, especially its foreign policy toward China in the early 20th century. It further argues that the alleged American “protection” for China in military, diplomatic and cultural domain was just an embodiment of racial superiority in U.S. foreign policy, which was a justification for the United States to invade and enslave other countries and establish world hegemony.
Review of The Sociolinguistics of Language
Authors: Ai-guo Wang
Published: March 2024

This piece is an introduction and a review of one of Ralph Fasold’s works, the Sociolinguistics of Language. From address forms to pragmatics, Prof. Fasold studied various language phenomena in social communications, including gender and language, discourse analysis, and creolistics. Pidgin and creole language phenomena should be examined in terms of processes instead of types of languages. To apply the theory into daily experiences, we should make efforts in language arts education.
Вопросы эмпирической радиометрической калибровки спектрометрической аппаратуры, установленной на БПЛА
Authors: Асадов Х.Г. , Гусейнова Р.О. , Алиева А.Дж. , Гумбатов Д.А.
Published: March 2024

Статья посвящена учету зависимости коэффициента отражения калибровочных наземных тест-панелей, используемых при викариозной эмпирической калибровке радиометрической спектральной аппаратуры, установленной на БПЛА, от длины волны излучения. С учетом эффекта насыщения цифровых отсчетов (DN) изображения целевого объекта из-за логарифмической зависимости DN от коэффициента отражения реальных объектов исследованы условия достижения максимума усредненного по всему диапазону длин волн значения DN. Показано, что такой максимум может быть обеспечен при наличии обратной зависимости между показателем крутизны отражательных характеристик тестовых панелей от длины волны. Сделан вывод о том, что реально используемые тестовые панели лучше подчиняются этому требованию при высоких значениях показателя «уровня серого».
Norma, território e fronteira: a política ambiental e a expansão da mineração em Minas Gerais
Authors: Magno Lucas , Gouvêa Yasmin Amarante Rodrigues , Oliveira Leonardo Rodrigues de , Penido Marina
Published: March 2024

O artigo tem como objetivo debater a política ambiental mineira a partir da observação das normas adotadas e de seus reflexos territoriais, destacando como a flexibilização ocorrida nos anos recentes, nos processos de licenciamento ambiental, influenciou a expansão da fronteira da atividade de mineração para distintas mesorregiões de Minas Gerais. A partir de revisão bibliográfica, pesquisa documental e dados disponíveis no Sistema de Consultas e Decisões de Processos de Licenciamento Ambiental da Secretaria de Estado de Meio Ambiente e Desenvolvimento Sustentável (Semad) e na Infraestrutura de Dados Espaciais (IDE) do Sistema Estadual do Meio Ambiente (Sisema) o texto realiza, inicialmente, a caracterização da institucionalização da política ambiental em Minas Gerais. Em seguida, analisa as mudanças recentes do licenciamento ambiental neste estado e, por fim, indica suas implicações territoriais, a partir do avanço da fronteira do setor mineral e dos territórios corporativos da mineração. As análises das mudanças no licenciamento e da expansão do setor mineral no estado abarcam o período entre 2013 e 2022.
Manejo de aneurismas cerebrales: Revisión de la literatura pasada, presente y futura
Authors: Campos Gamarra Rocío Nicole , Astudillo Palacios Mariana Gabriela , Gallo Guerrero Marla , Rojas Delgado Gonzalo , Palacios Garcia Jimmy
Published: March 2024

Introducción: El manejo de los aneurismas cerebrales ha ido evolucionando con el paso de los siglos. En esta revisión se hace un resumen de cómo se ha desarrollado el manejo médico, endovascular y quirúrgico en el abordaje de estas patologías que causan una gran morbi-mortalidad en la población.

Objetivo: Evaluar el manejo médico, endovascular y quirúrgico de los aneurismas cerebrales rotos y no rotos a lo largo del tiempo, desde las primeras veces en que fueron tratados hasta las innovaciones que se están llevando a cabo.

Métodos: Se realizó una revisión de artículos buscados en la base de datos de PubMed, buscando Mesh Terms con palabras seleccionadas relacionadas al tema.

Diseño de estudio: Revisión.

Métodos: Selección de estudios con palabras clave de PubMed, y según consenso de todos los autores. Extracción de datos en Rayyan.

Palabras claves: hemorragia subaracnoidea, aneurisma, neurocirugia, procedimientos endovasculares.