bluuebunny/crossref_metadata_2025 huggingface dataset:
Probabilistic modeling and optimization of leakages in water distribution networks
Authors: Σεραφείμ Αθανάσιος
Published: August 2024

Αναπτύσσουμε ένα ολοκληρωμένο πλαίσιο για τη μείωση των διαρροών στα δίκτυα ύδρευσης, το οποίο συνδυάζει: α) ένα σύνολο πιθανοτικών προσεγγίσεων για την εκτίμηση της ελάχιστης νυχτερινής ροής και την παραμετρική μοντελοποίηση των απωλειών νερού, και β) έναν συνδυασμό στατιστικών τεχνικών ομαδοποίησης και υδραυλικής μοντελοποίησης για τον διαχωρισμό των δικτύων ύδρευσης σε επιμέρους ζώνες διαχείρισης πίεσης (PMAs ή DMAs). Το πλεονέκτημα των προτεινόμενων πιθανοτικών μεθόδων είναι ότι επιτρέπουν την εκτίμηση διαστημάτων εμπιστοσύνης τόσο των παρατηρούμενων όσο και των παραμετροποιημένων ελάχιστων νυχτεριών ροών, λαμβάνοντας παράλληλα υπόψη την επίδραση της πίεσης λειτουργίας στις διαρροές. Η στατιστικώς αμερόληπτη από τον χρήστη προσέγγιση ομαδοποίησης (ζωνοποίηση) οδηγεί σε ρεαλιστικά πραγματοποιήσιμα αποτελέσματα, επιτρέποντας στους μηχανικούς και σε άλλους εμπλεκόμενους στον τομέα των υδάτων να αναπτύξουν αποτελεσματικές στρατηγικές για τη διαχείριση και τη μείωση των διαρροών, με βάση μια γρήγορη και εύκολη στην εφαρμογή αλγοριθμική διαδικασία. Η αποτελεσματικότητα του πλαισίου που αναπτύχθηκε εκτιμάται μέσω της εφαρμογής του στο δίκτυο ύδρευσης της πόλης της Πάτρας στη δυτική Ελλάδα, το οποίο εξυπηρετεί περίπου 213 000 καταναλωτές, αποτελείται από περισσότερα από 700 χιλιόμετρα δικτύου αγωγών (κυρίως σωλήνες HDPE και PVC) και περιλαμβάνει 86 περιοχές διαχείρισης πίεσης (ζώνες) εξοπλισμένες με αυτοματοποιημένους τοπικούς σταθμούς για την παρακολούθηση των παροχών νερού και τη ρύθμιση της πίεσης.
Lived experiences of women who survived from pre-eclampsia and eclampsia in public hospitals of Shashemene Town, Oromia Region, Ethiopia: a qualitative study.
Authors: Gebeyehu Negeso , Urgessa Aman , Yohannes Daniel , Yalew Aster , Ahmed Muluneh , Admasu Meron
Published: August 2024

Objective: The main purpose of this study was to explore experiences of women who survived pre-eclampsia and eclampsia in Shashemene referral hospital and Melka Oda general hospital, 2021. Design: An institution-based exploratory qualitative study with a descriptive phenomenological study design Setting: The present study was conducted in Shashemene referral hospital and Melka Oda general hospital from March 03 to May 18, 2021. Participants: A total of 17 individual in-depth interviews (IDIs) were conducted with women who experienced and survived pre-eclampsia and eclampsia. Data were analyzed through thematic analysis using Atlas-ti software. Result: The present study revealed that women’s level of awareness on raised blood pressure and or convulsion occurring during pregnancy was poor. Barriers that limit pregnant women from getting treatment at the earliest point included misconception, lack of insight, failure to accept counseling from health care providers, low income, and influence from husbands. Discussions with the women in this study showed that these mothers were not counseled on danger signs during antenatal care check-ups. Almost all of the women were very concerned and frustrated due to their diagnosis. Conclusions: Women’s awareness of pre-eclampsia and eclampsia was poor and antenatal care was not offered as per expected quality. Improving awareness of hypertensive disorders in pregnancy and enhancing the quality of antenatal care is essential.
Analyzing Nigeria's Journey Towards Sustainable Development Goals: A Comprehensive Review From Inception To Present
Authors: Oweibia Mordecai , Elemuwa Uchenna Geraldine , Akpan Emma , Daniel Elemuwa Tochukwu , Oruikor Gabriel Jeremiah , Tarimobowei Egberipou , Okoho Etim Elizabeth , Elemuwa Christopher Ononiwu , Raimi Morufu Olalekan , Babatunde Anuoluwapo Adebomi
Published: August 2024

Rationale This study critically examines Nigeria’s journey towards the Sustainable Development Goals (SDGs) since their inception. Nigeria, a United Nations member state and a major oil producer, faces challenges like socio-economic disparities, political instability, corruption, and prevalent poverty, despite its cultural richness and natural resources. Objectives The primary aim is to evaluate Nigeria’s alignment with the SDGs within its national development frameworks, highlighting the significance of these goals in addressing the country’s multifaceted developmental challenges. These challenges span various sectors including poverty, health, education, and environmental sustainability. Methods The study conducts a detailed analysis of Nigeria’s background, including its cultural diversity and developmental hurdles. It reviews national policies and initiatives, notably the Economic Recovery and Growth Plan (ERGP), and the role of the Ministry of Budget and National Planning in coordinating SDG efforts. Results Findings suggest partial progress in SDG integration within Nigeria’s development plans. While some strides have been made in areas like policy alignment and strategic planning, challenges persist in effective implementation and tackling systemic issues like inequality and corruption. Conclusion The analysis reveals that, while Nigeria has made efforts to incorporate the SDGs into national policies, significant gaps remain in addressing key challenges. The complexity of Nigeria’s socio-economic and political landscape presents both hurdles and opportunities for sustainable development. Recommendations The study advocates for more robust policy implementation, enhanced stakeholder engagement, and targeted strategies to overcome specific challenges. By addressing these areas, Nigeria can accelerate its progress towards the SDGs, paving the way for comprehensive and sustainable national development.
Radial nerve palsy associated with fractures of the humerus shaft: a review of the literature and current treatment trends
Authors: Jang Hyo Seok , Lee Sang Hyun , Chang Won June , Kim Yong Jin
Published: August 2024

Due to the anatomical characteristics of the radial nerve, a humeral shaft fracture can induce radial nerve palsy. Although the treatment for radial nerve palsy remains debatable, the options can be broadly classified as early exploratory surgery and initial expectant treatment. In cases of secondary paralysis, the definitive treatment primarily depends on the causative factor, with appropriate consideration of other important factors, such as the fracture characteristics and the patient's age and occupational factors, and after adequate discussion with the patient. However, if radial nerve function does not recover, a tendon or nerve transfer may be considered.
Predictores psicolingüísticos de la adquisición y aprendizaje del inglés como segunda lengua
Authors: Arango Tobón Olber Eduardo , Puerta Lopera Isabel Cristina , Montoya Zuluaga Paula Andrea , Sánchez Duque José Wilmar
Published: August 2024

Las habilidades y competencias psicolingüísticas de la lengua materna (L1) parecen desempeñar un papel fundamental en la adquisición y aprendizaje de una segunda lengua (L2). El objetivo de este estudio fue establecer los predictores psicolingüísticos de L1 para la adquisición y aprendizaje del inglés como L2. La muestra estuvo conformada por 111 niños, estudiantes de instituciones educativas públicas de la ciudad de Medellín. Los resultados de esta investigación sugieren la existencia de dos factores psicolingüísticos considerados como fuertes predictores de L1 para la adquisición del inglés como L2; el primer factor se denominó análisis sintáctico y un segundo factor fue denominado fonolexical. En conclusión, las habilidades en L1 y las aptitudes para la adquisición de L2 están estrechamente relacionadas o, por lo menos, el perfil psicolingüístico en L1 es fundamental para la adquisición y el aprendizaje del inglés como L2.
Stress Testing Spillover Risk in Mutual Funds
Authors: Capponi Agostino , Glasserman Paul , Weber Marko Hans
Published: August 2024

We develop a framework to quantify the vulnerability of mutual funds to fire-sale spillover losses. We account for the first-mover incentive that results from the mismatch between the liquidity offered to redeeming investors and the liquidity of assets held by the funds. In our framework, the negative feedback loop between investors’ redemptions and price impact from asset sales leads to an aggregate change in funds’ net asset value, which is determined as a fixed point of a nonlinear mapping. We show that a higher concentration of first movers increases the aggregate vulnerability of the system as measured by the ratio between endogenous losses triggered by fund redemptions and exogenous losses caused by initial price shocks only. When calibrated to U.S. mutual funds, our model shows that, in stressed market scenarios, spillover losses are significantly amplified through a nonlinear response to initial shocks that results from the first-mover incentive. Higher spillover losses provide a stronger incentive to redeem early, further increasing fire-sale losses and the transmission of shocks through overlapping portfolio holdings.

This paper was accepted by David Simchi-Levi, finance.

Funding: The research of A. Capponi has been supported by the National Science Foundation–Civil Mechanical and Manufacturing Innovation) CAREER grant [Grant 1752326]. The research of M. H. Weber has been supported by the NUS Start-Up grant [Grant A-0004587-00-00] and the Singapore MOE Tier 1 grant [Grant A-8000966-00-00].

Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2022.03443 .
Earnings Pressure and Corporate Social Responsibility Impression Management
Authors: Liu Chang , Zhao Xiaoping
Published: August 2024

Extensive research has investigated the buffering effect of corporate social responsibility (CSR) when firms have poor financial performance. However, few studies have examined the possible consequences of this effect. By analyzing data on listed firms in China from 2010 to 2018, this study investigates the buffering effect of CSR under conditions of earnings pressure, and then discusses its impact on CSR disclosure impression management behavior. The results show that CSR can buffer the negative impact of earnings pressure on stock prices, chief executive officer stability, and top management team stability. This buffering effect is mainly exerted by technical CSR. Moreover, earnings pressure leads to CSR disclosure impression management without resulting in improved CSR performance. These findings have implications for cultivating CSR buffering awareness among firms and managers. The results also have practical implications for future research on the antecedents and motivations of CSR disclosure impression management.

Funding: This work was supported by the National Natural Science Foundation of China [Grant 72372104].
EVALUATION OF PATIENT SAFETY STEPS IN GENERAL HOSPITAL OF YOGYAKARTA CITY (RSUD YOGYAKARTA CITY)
Authors: Apriyani Wilda , Sofiana Liena
Published: August 2024

Background of Study: Patient Safety of hospital is a system where the hospital makes patient adoption safer. In giving a quality of guarantee provide health and patient safety, this hospital is applying patient safety program. The result of our acknowledgements show SOP that has not been working as accurately. At this incident should be told 2x24 hours maximal, sometime there is exceeding the line and it is not reported. The purpose of this project is to evaluate the step of patient's safety that has been applied at the inpatient installation in the regional hospital of Yogyakarta.Research Method : this research isÂ  a qualitative research with case approach to 6 informan that used an interview guidance and check list which is refering to the minister of health on Patientâ€™s Safety. Analysis data used data reduction, data display and conclusion.The results of study: the result of this research showed six of seven steps of patient safety has been working with the rule of minister of health about of patient safety, althought in progressing need an increasing . However, your leaders and proponentsÂ  has not been working with the rule of minister of health about of patient safety.Conclusion : this research is one of seven steps of patient safety, 6 steps has been working with the rule of minister of health about of patient safety.
The Relationship of the Clinical Practice Environment, Supervision and Supervisors with Students' Clinical Experience as an Effort to Prepare Professional Nurse Graduates
Authors: Susanti Devi , Herlitawati Herlitawati , Hidayat Taufik , Yusnaini Yusnaini
Published: August 2024

Background: Learning turns theoretical knowledge into practice for nursing students. The quality of a student's clinical experience is influenced by the practice environment, supervision, and supervisor. The clinical practice environment influences the approach and achievement of student competencies. Supervision is important for quality nursing care, while effective supervisors act professionally and guide students in managing patients. This study aims to analyze the relationship between the clinical practice environment, supervision and supervisors with the clinical experience of students as an effort to prepare professional nurse graduates in the D-III Nursing study program in Kutacane, Poltekkes Kemenkes Aceh, totaling 64 students with a sampling technique, namely total sampling based on inclusive criteria. Methods: Type of research This is a correlational analytical descriptive with a cross sectional approach. Data analysis was carried out via Univariate and Bivariate. Results: The results of this research show that there is a significant relationship between the clinical practice environment, supervision and supervisors with the clinical experience of students in the D-III Nursing study program in Kutacane, Poltekkes Kemenkes Aceh with p-values of 0.033, 0.024 and 0.015. Conclusion:  Therefore, it is recommended that collaboration between educational institutions and health institutions be strengthened to create an optimal clinical practice environment.
ANALISIS KERAWANAN LONGSOR SEBAGAI UPAYA MITIGASI MENGGUNAKAN SISTEM INFORMASI GEOGRAFIS DI DAERAH LAMPUNG BARAT
Authors: Mulyasari Rahmi , Agustin Erisa , Yuniza Nani , Haerudin Nandi , Riduan Riduan
Published: August 2024

The West Lampung area is an area that is prone to landslides, this is due to the high intensity of rainfall and unstable soil structure. In 2022 and 2023, landslide disasters occurred in the West Lampung area which resulted in many losses, so it is necessary to carry out a landslide vulnerability analysis as an anticipatory measure for landslide control measures. By utilizing a geographic information system, geological data, slope, soil type, rainfall and land cover to display areas that are indicated to be prone to landslides. Based on the results of spatial analysis of each landslide-causing parameter, it produces 3 levels of landslide susceptibility classes, namely areas not prone to landslides (95.48 km2), areas prone to landslides (85.85 km2) and areas very prone to landslides (155.43 km2). In areas that are indicated to be vulnerable and very vulnerable, it is necessary to carry out mitigation on sloping areas and land use in these areas.
Can the Pioneering Impact of Artificial Intelligence in Anaesthetic Practice Uphold Good Medical Practice?
Authors: Sara Tajveer , Mandour Yasser
Published: August 2024

The potential applications of Artificial Intelligence (AI) in anaesthesia are expansive.~However, like any technological advancement, the integration of AI in anaesthetic practice comes with both benefits and potential risks. This article seeks to set out some of the advantages and disadvantages of the use of AI technologies within the field of anaesthesia. Benefits of the application of AI in anaesthesia include an improvement in perioperative risk stratification, personalisation of anaesthetic plans, improvement in efficiency and ultimately reduce healthcare costs. However, reliance on technology may reduce clinical acumen but furthermore there are issues surrounding data quality, privacy as well as legal and ethical concerns, which require further evaluation. Whilst AI within anaesthetic practice holds immense promise, there are substantial challenges which require careful consideration and ongoing evaluation. A collaborative approach will be required from healthcare staff, developers and regulators to promote the safe, responsible, and effective application of AI in anaesthesia practice.
Efficacy and Safety of Nerve Growth Factor in Treating Neurotrophic Keratitis Patients: A Meta-Analysis
Authors: Luo Xianling , Tang Aiping
Published: August 2024

Aims/Background Nerve growth factor has been approved for treating neurotrophic keratitis in Europe and the United States. However, its clinical efficacy and safety profile in neurotrophic keratitis patients have not been systematically evaluated. Therefore, this study systematically assessed the efficacy and safety of nerve growth factor (NGF) in treating patients with neurotrophic keratitis.

Methods Various databases, including Wanfang, China National Knowledge Internet (CNKI), Embase, PubMed, and Web of Science were systematically searched. This search included all articles published up to January 2024. Moreover, these articles were thoroughly reviewed and carefully screened following predetermined inclusion and exclusion criteria. Furthermore, the quality of the included studies was assessed using the Cochrane Risk of Bias Manual 5.3 (The Cochrane Collaboration, London, UK). Stata26.0 (StataCorp LLC, College Station, TX, USA) was used for meta-analysis. The outcome indicators evaluated in this study included corneal healing efficiency, corneal complete healing rate, best vision correction rate, ailment progression, and the number of adverse events.

Results A total of 4 articles were included in this study, including 293 sufferers. The findings from the meta-analysis revealed that the corneal healing efficiency (odds ratio (OR) = 1.72, 95% confidence interval (CI): 1.20–2.45), the corneal complete healing rate (OR = 2.23, 95% CI: 1.41–3.54), and the best visual acuity correction rate (OR = 1.97, 95% CI: 1.11–3.47) were significantly higher in the experimental group compared to the control group. However, the incidence of ailment progression (OR = 0.44, 95% CI: 0.17–1.13) and adverse events (OR = 0.88, 95% CI: 0.50–1.56) did not show significant differences between these two groups.

Conclusion In summary, for patients with neuropathic keratitis, NGF treatment can promote corneal healing efficiency, effectively improve visual correction, and reduce disease progression and incidence of adverse events to a large extent. The clinical effect and safety are high, and it is worthy of clinical promotion and application.
Off-axis holographic imaging with undetected light
Authors: León-Torres Josué R. , Krajinić Filip , Kumar Mohit , Gilaberte Basset Marta , Setzpfandt Frank , Gili Valerio Flavio , Jelenković Branislav , Gräfe Markus
Published: August 2024

Quantum imaging with undetected light (QIUL) leverages the quantum correlations of photon pairs generated via spontaneous parametric down-conversion (SPDC) to retrieve both amplitude and phase information of an object. This method enables illumination and detection at distinct wavelength ranges, utilizing advanced detection technology in the visible spectrum while probing the object at an exotic wavelength. Here, we experimentally demonstrate a QIUL technique incorporating Fourier off-axis holography within a hybrid-type induced-coherence nonlinear interferometer. Our approach reconstructs the amplitude and phase information of an object in a single shot using a wide-field configuration, presenting a viable alternative to multi-frame acquisition techniques such as phase-shifting holography.
GAPANet: group alternate perceived attention network for optical imaging infrared thermal radiation effect correction
Authors: Shi Yu , Niu ShanLin , Wu FeiYan , Deng XinYuan , Huang LiKun , Liang Chao
Published: August 2024

To address the problem of insufficient information interaction between different dimensions of image features, and the inability of real-time simultaneously in the current thermal radiation effect correction methods, in this paper, we construct a group alternate perceived attention network. At coarser scales, the group alternate perceived attention module is constructed, which requires only fewer parameters and computational complexity. The group alternate perceived attention module mainly consists of two alternating parts: a global attention block combined with the local feature of three-branch dilated convolution, and a channel attention block for local information interaction. At the finest scale, a dimensional information interaction attention module is constructed. The correction network fully realizes attention perception at the inter-dimensional level globally and channel level locally. The experimental results of a large number of simulated and actual degraded images show that our model corrects better and realizes real-time.
Factors associated with glycaemic control and diabetes complications in patients at Bugando Medical Centre, Mwanza, Tanzania: A cross-sectional study design
Authors: Muchunguzi Aneth H. , Kimaro Emmanuel , Konje Eveline T. , Kidenya Benson R. , Mori Amani T. , Kaale Eliangiringa
Published: August 2024

Background

Glycaemic control is essential for improving the quality of life in patients with Diabetes Mellitus (DM). Untreated hyperglycaemia can result in numerous severe and life-threatening complications, such as damage to the eyes, kidneys, nerves, heart, and peripheral vascular system. Appropriate glycaemic control and management is fundamental to prevent and delay diabetes complications. Therefore, this study aims to assess the prevalence of poor glycaemic control, its associated factors, and the prevalence of diabetes-related complications among DM patients.

Methods

A cross-sectional study was conducted among 340 DM patients treated at Bugando Medical Center from 4th - 30th April 2023 to determine the prevalence of poor glycaemic control and its predictors. Secondary data from 7952 DM patients treated between April 2022 and 30th May 2023 were used to determine DM-related complications. STATA 15 version …was used for analysis.

Results

Out of 340 patients, 66.4% had poor glycaemic control with HbA1c or Random Blood Glucose greater than 7% or 7mmol/L, respectively. Older age, duration of DM of more than 10 years, insulin therapy, and those unaware of glycaemic target goals were factors associated with poor glycaemic control. (AOR: 2.46, 95% CI: 1.28–6.01, P = 0.03), (AOR: 3.15, 95% CI: 2.22–6.55, P = 0.016), (AOR: 3.07, 95% CI: 2.10–6.12, P = 0.022) and (AOR: 3.42, 95% CI: 2.17–5.97, P = 0.001), respectively. Of the 7952 patient records reviewed indicated that 44.5% had complications, of which 25.8% had neurological complications and 55.3% had multiple complications.

Conclusion

Two-third of DM patients failed to achieve good glycaemic control and about half of the patient’s records reviewed indicated they developed diabetic complications. Thus appropriate interventions are necessary to improve glycaemic control and prevent or control complications among DM patients.
A grounded theory exploration of the enablers and barriers of public healthcare access for people with comorbid serious mental and chronic physical illnesses in Jamaica
Authors: Whitehorne-Smith Patrice , Lalwani Kunal , Martin Robyn , Mitchell Gabrielle , Milbourn Ben , Abel Wendel , Burns Sharyn
Published: August 2024

Chronic physical illnesses (CPI) are highly prevalent among people with serious mental illnesses (PWSMI) yet people in this population experience significant challenges accessing healthcare. This study utilised a constructivist grounded theory approach to collect and analyse data related to the enablers and barriers to public healthcare access for PWSMI & CPI. Data were collected through semi-structured interviews conducted with fifty-seven participants comprising PWSMI &CPI and their caregivers, health policymakers, primary care physicians, psychiatrists, and mental health nurses. Enablers and barriers to healthcare access were represented using a socio-ecological model consisting of five levels: wider society, health system, clinician, family and community, and individual. Jamaica’s free public healthcare system was the most pronounced enabler of healthcare access, while poverty, stigma, and discrimination were the most pronounced barriers. Factors such as social support, time, clinician beliefs, attitudes and training, and individual characteristics were identified as consisting of dimensions that were both enablers and barriers to healthcare access. These findings indicated that factors that influenced healthcare access for PWSMI & CPI were aligned with the social determinants of health. Improved healthcare access for PWSMI & CPI necessitates strategies that incorporate a multi-sectoral approach to address social and environmental factors influencing healthcare access across all levels of the socio-ecological model.
Factors that determine the connectedness with nature in rural and urban contexts
Authors: Macias-Zambrano Luis , Cuadrado Esther , Carpio Antonio J.
Published: August 2024

Connectedness with nature is considered a key element for the future of conservation. There are both internal and external factors that determine the levels of connectedness with nature. Among these factors are gender, age, knowledge about the environment and place of residence. In the latter case, there may be differences in how urban and rural dwellers perceive nature, based on their experiences and contact with it. The main objective of this research is to evaluate and establish the factors that influence and determine the levels of connection with nature, examining how these factors relate and interact with each other, taking the urban and rural context as starting point. The ABC-CNS scale, which addresses the affective, behavioural and cognitive aspects of the connection with nature, was applied via online questionnaire to a sample of university students from two countries, Spain (496 students) and Ecuador (872 students), who were also clustered according to career, age, gender, and place of residence. The results obtained through four General Linear Mixed Models (ABC-CNS and its dimensions as response variables) and LSD test, demonstrated that the ABC-CNS scale presented significant differences for all the variables analyzed (place of residence, gender, age, and career), also demonstrating which levels influence and interact in higher ABC-CNS values. Finally, the study concludes that the analyzed factors contribute to the development of the connection with nature. In the case of place of residence, attention should be given to the specific settings of the environments under study.
Protective RBD-dimer vaccines against SARS-CoV-2 and its variants produced in glycoengineered Pichia pastoris
Authors: Zhao Tongxin , Liu Sheng , Wang Pengyan , Zhang Yanfang , Kang Xinrui , Pan Xiaoqian , Li Linjie , Li Dedong , Gao Ping , An Yaling , Song Hao , Liu Kefang , Qi Jianxun , Zhao Xin , Dai Lianpan , Liu Peipei , Wang Peiyi , Wu Guizhen , Zhu Taicheng , Xu Kun , Li Yin , Gao George F.
Published: August 2024

Protective vaccines are crucial for preventing and controlling coronavirus disease 2019 (COVID-19). Updated vaccines are needed to confront the continuously evolving and circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. These vaccines should be safe, effective, amenable to easily scalable production, and affordable. Previously, we developed receptor binding domain (RBD) dimer-based protein subunit vaccines (ZF2001 and updated vaccines) in mammalian cells. In this study, we explored a strategy for producing RBD-dimer immunogens in Pichia pastoris. We found that wild-type P. pastoris produced hyperglycosylated RBD-dimer protein containing four N-glycosylation sites in P. pastoris. Therefore, we engineered the wild type P. pastoris (GS strain) into GSΔOCH1pAO by deleting the OCH1 gene (encoding α-1,6-mannosyltransferase enzyme) to decrease glycosylation, as well as by overexpressing the HIS4 gene (encoding histidine dehydrogenase) to increase histidine synthesis for better growth. In addition, RBD-dimer protein was truncated to remove the R328/F329 cleavage sites in P. pastoris. Several homogeneous RBD-dimer proteins were produced in the GSΔOCH1pAO strain, demonstrating the feasibility of using the P. pastoris expression system. We further resolved the cryo-EM structure of prototype-Beta RBD-dimer complexed with the neutralizing antibody CB6 to reveal the completely exposed immune epitopes of the RBDs. In a murine model, we demonstrated that the yeast-produced RBD-dimer induces robust and protective antibody responses, which is suitable for boosting immunization. This study developed the yeast system for producing SARS-CoV-2 RBD-dimer immunogens, providing a promising platform and pipeline for the future continuous updating and production of SARS-CoV-2 vaccines.
Simulating reality: Stage actors’ emotional labour strategies and experienced outcomes
Authors: Perminiene Milda , Mbayo Loriane
Published: August 2024

The study aims to explore emotional labour strategies and the associated outcomes among stage actors. Data were gathered over one-to-one qualitative interviews with seven theatre actors. Acting experience ranged from three to 42 years. Five emotional labour strategies emerged, i.e. (1) technical work, (2) relying on inner resources, (3) empathizing with a character, (4) transforming self and (5) relying on others. The outcomes of emotional labour extended from benign to pernicious, encompassing four themes: (1) fusion of professional–personal identities, (2) overidentification with a character, (3) constructive outcomes (emotional intelligence and superior performance onstage) and (4) conditional factors (individual characteristics and peculiarities of the play). This article raises awareness of emotional labour strategies and outcomes. Interpretation of findings viewing from an organizational psychology perspective allows to identify potential impact of organizational factors and consider practices that address mental health at work, work–life balance and personal–professional identity fusion among stage actors.
Cultural genesis of children’s musicals in the period of independent Ukraine
Authors: Belymenko Liliana , Vakulenko Olesia , Krypchuk Mykola , Yahych Viktoriia , Nabokov Roman
Published: August 2024

In the context of the intensification of the national movement, it becomes essential to delve into the authenticity and origins of one’s culture, whose historical path is at odds with imperial Russian and Soviet propaganda. The idea that many cultural processes of modern times have their roots in the European past is the key to a proper future, historically natural for Ukraine. The purpose of the research is to examine the development of children’s musicals during the period of Ukrainian independence, identifying the specific features of the genre that developed on the stages of Ukrainian music and drama theatres and were embodied in film adaptations. The research is based on the method of systematic analysis and comparative method. The nuances of the genesis and development of the Ukrainian children’s musical are identified through genre and style art and musicological analysis. This research examines the cultural genesis of children’s musicals during the period of independent Ukraine. It highlights these musicals as evidence of the intensification of multi-genre processes in the Ukrainian stage and artistic industry. The study concludes that children’s musicals of the last few decades represent a synthesis of ideological and aesthetic features of the national school with international elements, showcasing a unique interaction of the past with the present. Based on scientific research, the research presents a hypothesis about the Ukrainian children’s musical as a derivative of European musical and dramatic genres (e.g. rock opera) and considers the renewal of audience demand and the reorganization of the musical and acting repertoire, which are caused by the entry of a new genre into the Ukrainian arena. The practical significance of the research lies in identifying the specific features of the genre and defining the main mistakes of independent Ukrainian cinema, which will be useful for specialists in Ukrainian musical theatre in developing new examples of the genre according to the nuances of its development in Ukraine, and for scholars who will develop the field of research on Ukraine’s cultural achievements.
Theoretical Studies on Reactivity Indices, Electronic, Optical and Thermodynamics Properties of Pentacene-Tetrapyrrole Derivatives using DFT Method
Authors: Manisha  , Dangi Vijay , Arya Brahamdutt
Published: August 2024

A detailed theoretical analysis of the electronic properties, reactivity indices, optical and thermodynamic properties of pentacene-tetrapyrrole (PTP) molecules utilizing the DFT and TD-DFT methods at 6-311(d,p) basis set is conducted. The thermodynamic properties and molecule electrostatic potential were computed using the DFT/B3LYP/6-311(d,p) technique. The electronic properties, reactivity indices and optical properties were determined using the TD-DFT/6-311(d,p) at several functionals: B3LYP, CAM-B3LYP, B3PW91, PBEPBE and WB97XD. The change in electronic properties, reactivity indices, optical and thermodynamic properties were also investigated with variation in the position of the –NH group at the pentacene’s periphery from inward to outward and central benzene ring of pentacene with nitrogen containing cyclic rings such as pyrrole in pentacene-tetrapyrrole derivatives.
Physical and Chemical Properties of Poly(ethylene)oxide Ternary Solid Polymer Electrolytes Based on Ni/Al Layered Double Hydroxide
Authors: Mohd Johari Siti Nurul 'Afini , Deraman Siti Khatijah , Hanibah Hussein , Tajuddin Nazrizawati Ahmad
Published: August 2024

In this work, a solid polymer electrolyte (SPE) was synthesized by solution casting technique using poly(ethylene oxide) (PEO) as polymer host doped with lithium trifluoromethanesulfonate (LiCF3SO3) and Ni/Al layered double hydroxide (Ni/Al LDH) as filler. Subsequently, Ni/Al LDH were introduced into the polymer electrolyte and characterized by electrochemical impedance spectroscopy (EIS) to determine the composition of additive, which gives the highest conductivity for each system. At ambient temperature, the highest conductivity is obtained for the composition PEO–5 wt.% Ni/Al LDH–8 wt.% LiCF3SO3 with a value 8 × 10–6 S cm–1. X-ray diffraction (XRD) studies indicate that the conductivity increase is due to an increase in amorphous content which enhances the segmental flexibility of polymeric chains and the disordered structure of the electrolyte. For composites, the characteristic peaks of Ni/Al LDH disappeared irrespective of filler content. The presence of complexation and interaction among the components was demonstrated by FTIR spectra, while images captured by FESEM revealed the morphological changes in the solid polymer electrolyte.
Ecofriendly Synthesis, Spectroscopic Analysis and in silico Study of Coumarin Hydrazide-Hydrazone Derivative Targeted against HIV and SARS-CoV-2
Authors: Gautam Shipra , Rawat Poonam , Prakash  , Ram Anant , Darwari Amul , Pandey Sharda , Pandey Anupama , Singh R.N.
Published: August 2024

Coumarin based hydrazide-hydrazone (CHH) derivative was synthesized and evaluated for in silico antiviral activity against SARS-CoV-2 and anti-HIV activity. The experimental techniques (FT-IR, 1H NMR, 13C NMR and UV-vis) and computational calculations (B3LYP functional and 6-31G(d,p)/6-311G(d,p) level of theory) were used for the detailed analysis of the synthesized compound. By following the mechanosynthesis methodology, the excellent yield and reduction in reaction time were observed in the grinding method when compared to conventional method. The rotational barrier between conformer I and II of CHH was found to be 5.102 Kcal/mol in the gas phase. The FT-IR spectrum was carried out to support the hydrogen bonding pattern proposed by reported crystalline structure. The electronic descriptors studies indicate CHH used as useful synthon for new heterocyclic compounds. The first static hyperpolarizability (β0) of the CHH was calculated as 17.47 and 25.93 10–30 esu at B3LYP/6-31G (d,p) and B3LYP/6-311G(d,p) basis set indicates CHH may be used as non-linear optical material. The ADMET, isoelectronic molecular electrostatic potential surfaces (MEPS), NBO and QTAIM studies were also performed. According to molecular docking, the synthesized CHH compound showed strong antiviral efficacy against SARS COV-2 major protein (Mpro) with PDB code 6lu7 and anti-HIV antibody DH501, an unmutated common ancestor with PDB ID 6p3b.
Synthesis of Nanocellulose Facilitated by Ionic Liquid using Pongamia pinnata as Biomass Resource
Authors: Pradeep H.K. , Patel Dipti H.
Published: August 2024

The successful transformation of cellulose into nanocellulose was conducted from Pongamia pinnata utilizing ionic liquid, 1-butyl-3-imidazolium chloride, as a swelling agent and catalyst. The SEM analysis revealed the presence of a fibrillar structure, disordered agglomerates, highly organized and smooth nanofibers. The studies confirmed the presence of thread-like structures and the existence of strong intermolecular linkages as that of cellulose. The X-ray diffraction (XRD) study and thermogravimetric analysis (TGA) demonstrated that the semicrystalline nature of nanocellulose retained and exhibited stable thermal characteristics. The utilization of 1-butyl-3-imidazolium chloride as a catalyst and swelling agent has presented an efficient and eco-friendly approach for the synthesis of nanocellulose.
Synthesis and Antitubercular Activity of Novel 1,5-Naphthyridin-2(1H)-one based Carbohydrazide Derivatives
Authors: Chilakala Nagendra Babu , Thumma Vishnu , Raju B. , Etnoori Sharada , Boddu Lakshmi Satya , Premalatha K.
Published: August 2024

A library of novel 1,5-naphthyridin-2(1H)-one based carbohydrazide derivatives (6a-j) were synthesized involving functional group interconversion, esterification and coupling reactions. All the newly synthesized carbohydrazide derivatives (6a-j) were evaluated for their ability to inhibit the growth of M. tuberculosis mc26230 by determining their minimum inhibitory concentration (MIC), with rifampicin used as the standard reference. Compound 6f (3-cyano) displayed potent activity with a MIC value of 4 µg/mL, compound 6g (4-cyano) displayed activity with an MIC value of 8 µg/mL, whereas the ortho-substituted cyano compound 6e showed activity a little lower with MIC of 16 µg/mL. Whereas all other compounds displayed good to moderate activity. The molecular docking study of potent compound 6f against crystal structure of dihydrofolate demonstrated a significant docking score and binding interactions in support of experimental investigations.
Hubungan Pola Makan dengan Stunting pada Balita di Puskesmas Jambula
Authors: Syuaib Abdu Ar’Rauf , Yati Sri , Marsaoly Ryan Rinaldy
Published: August 2024

Latar belakang. Keadaan gagal tumbuh yang disebabkan oleh kurangnya nutrisi selama masa kehamilan dan periode awal balita yang ditandai dengan panjang badan atau tinggi badan kurang-minus dua stadar deviasi menurut kurva pertumbuhan World Health Organization adalah stunting. Saat ini, menurut data 22,2% atau 150,8 juta anak di bawah usia lima tahun di dunia mengalami stunting, salah satunya dipengaruhi oleh pola pemberian makan.Tujuan. Untuk menjelaskan hubungan pola pemberian makan dengan derajat stunting pada balita di wilayah kerja Puskesmas Jambula.Metode. Penelitian analitik observasional ini dilakukan dengan pendekatan cross-sectional. Sampel pada penelitian ini adalah ibu yang memiliki balita usia 12-59 bulan. Data yang di peroleh dianalisis menggunakan Metode Fisher Freeman Halton Exact Test.Hasil. Berdasarkan 40 sampel yang di teliti, pola pemberian makan tidak tepat paling banyak didapatkan yaitu 34 responden (85%), sementara derajat stunting balita paling banyak ditemukan pada derajat pendek yaitu 28 balita (70%). Berdasarkan hasil analisis bivariat diperoleh nilai (p=0,006) yang menunjukkan korelasi antara pola pemberian makan dengan derajat stunting pada balita. Pola pemberian makan yang tidak tepat berisiko meningkatkan derajat stunting dengan nilai Odds Ratio 19,286 kali dibanding pola pemberian makan yang tepat Kesimpulan. Terdapat hubungan pola pemberian makan dengan derajat stunting pada balita di wilayah kerja Puskesmas Jambula serta pola makan yang tidak tepat dapat mengakibatkan stunting. Sebagai tenaga kesehatan, perlu melakukan pemeriksaan sesuai dengan prosedur yang berlaku.
Os limites curriculares e suas implicações no Curso Experimental de Medicina da USP (1968-1974)
Authors: Vane Lys Angélica Lamera , Vane Matheus Fachini , Vieira Joaquim Edson
Published: August 2024

O “Curso Experimental de Medicina” da USP originado na década de 1960 propôs a integralidade “bio-psico-social” da saúde e da doença em seu currículo. Seu método de ensino, inspirado em estratégia “Aprendizado Baseado em Problemas”, mostrava situações de saúde reais como racional para objetivos da aprendizagem centrada no estudante para a solução desses problemas. Os dois cursos de medicina na USP de São Paulo – o vigente, denominado tradicional e o novo, experimental, não tiveram coexistência administrativa harmoniosa. Em 1974 passam pela sua “fusão curricular”. Este texto relata entrevistas semiestruturadas realizadas entre 2014 e 2016. As reflexões dos seus então professores e estudantes referendam essas análises. Sugerem a formação de um grupo idealista com forte identificação com o curso. As entrevistas indicam que seus fundamentos foram constituídos em voluntariosa formação pedagógica dos docentes que impuseram limites ao novo currículo.
Visibilidades à historicidade dos Grupos Escolares gaúchos no século XX: em perspectiva regional da História da Educação do Rio Grande do Sul
Authors: Ripe Fernando , Vieira Bruno Carvalho
Published: August 2024

A obra, aqui resenhada, intitulada Escola primária no Rio Grande do Sul no século XX: os Grupos Escolares, é uma coletânea organizada pelo historiador da Educação, José Edimar de Souza, que foi recentemente publicada pela editora curitibana CRV no ano de 2023. Professor da Universidade de Caxias do Sul (UCS), atuando no ensino da Graduação e da Pós-Graduação, Edimar é exemplo de comprometimento com a pesquisa científica no campo da História da Educação. Ele é autor de inúmeros artigos, organizador de livros e capítulos, profícuo e sempre presente aos eventos do campo apresentando pesquisas que transitam desde as práticas educacionais, instituições educativas, processos de escolarização, culturas escolares (sujeitos, espaços, tempos, disciplinas, materialidades, etc.), até temáticacas que atravessam a Educação, como processos de (i)migrações, gênero e etnia. Nos últimos anos, o pesquisador gaúcho da cidade de Campo Bom, tem se dedicado a explorar as singularidades dos Grupos Escolares do Rio Grande do Sul (RS), notadamente aqueles que foram implantados em três zonas de imigração germânica e italiana, quais sejam: Região Norte, Serra Gaúcha e Vale dos Sinos.
PELAKSANAAN KONSELING BAGI PECANDU NARKOBA DI BADAN NARKOTIKA NASIONAL KABUPATEN TAPANULI SELATAN
Authors: Hidayat Arifin
Published: August 2024

Abuse of drug use is increasingly widespread, ranging from children, adolescents, adults, to the elderly. Users of various academic circles, politicians, artists (public vigur), and even students also use drugs. According to data released by BNN until March 2021, the Covid-19 situation also confiscated 3,462.75 kg of cannabis evidence, an increase of 143.64 percent compared to 2,419 kg of evidence in 2020. Even President Jokowi Dodo mentioned drug dealers and users. sentenced to death, but it turns out that there are still many people who consume drugs. This condition is very worrying and requires alternative solutions to change the behavior of drug addicts, BNN as one of the official state institutions in charge of dealing with drugs, it is important to make its best efforts, one of which is through counseling. This study wanted to describe the counseling process at the BNN in South Tapanuli Regency for drug addicts. Furthermore, this study uses a descriptive qualitative approach to the field. As for the results of the research, that BNN carried out the counseling process through the stages of assessment, planning, implementation, evaluation, and follow-up. However, there are still several obstacles, including: the introverted nature of the counselee, indiscipline, self-awareness, the counselor's academic ability, facilities and so on. So far, South Tapanuli BNNK has managed to cure 25 of 75 drug addicts. While those who have not recovered are still in the process of rehabilitation. As for the results of the research, that BNN carried out the counseling process through the stages of assessment, planning, implementation, evaluation, and follow-up. However, there are still several obstacles, including: the introverted nature of the counselee, indiscipline, self-awareness, the counselor's academic ability, facilities and so on. So far, South Tapanuli BNNK has managed to cure 25 of 75 drug addicts. While those who have not recovered are still in the process of rehabilitation. As for the results of the research, that BNN carried out the counseling process through the stages of assessment, planning, implementation, evaluation, and follow-up. However, there are still several obstacles, including: the introverted nature of the counselee, indiscipline, self-awareness, the counselor's academic ability, facilities and so on. So far, South Tapanuli BNNK has managed to cure 25 of 75 drug addicts. While those who have not recovered are still in the process of rehabilitation. South Tapanuli BNNK has successfully cured 25 of 75 drug addicts. While those who have not recovered are still in the process of rehabilitation. South Tapanuli BNNK has successfully cured 25 of 75 drug addicts. While those who have not recovered are still in the process of rehabilitation.
 Keywords: Counseling, Drug Addict, Behavioral Counseling
Mohammad Sjafei: A Nationalist Educator in West Sumatra
Authors: Wati Listia Anita , Rochwulaningsih Yety , Puguh Dhanang Respati
Published: August 2024

This article discusses Mohammad Sjafei's nationalist thoughts in the fields of politics and education from 1914 to 1958. This research uses historical methods. The article contains a description of how the educational system under the Ethical Policy program provided opportunities for the rise of nationalism among the indigenous people. The expansion of education encouraged openness of mind and knowledge among the indigenous population. This process of nationalist awakening stimulated the emergence of national thinkers who played a role in the struggle during the movement era. The role and contribution of these national thinkers are important to study in order to enhance understanding and knowledge in the field of intellectual history. One such national thinker examined in this article is Mohammad Sjafei. He was a national education figure who had nationalist thoughts in the fields of politics and education. His nationalist thoughts in politics encompassed values of unity, national loyalty, and love for the nation. His nationalist thoughts in education emphasized the importance of forming the nation’s identity and promoting education that is Indonesiacentric. Sjafei implemented these two nationalist thoughts in his educational practices at Indonesisch Nederlandsche School Kayutanam. The school was used as a medium to disseminate nationalistic awareness, sharpen intellectual intelligence, and develop skills.