bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between objectively measured conversation time and social behavior in community-dwelling older adults
Authors: Kimura Noriyuki , Masuda Teruaki , Ataka Takuya , Matsubara Etsuro
Published: October 2024

Background

Social isolation is a significant public health concern in aging societies. The association between conversation time and social behavior remains unclear. This study examines whether objective conversation time is associated with social activity frequency in older adults.

Methods

This prospective cohort study enrolled 855 older adults (538 women; mean age, 73.8 years) aged 65 and older, who were followed from 2015 to 2019. All participants wore a wristband sensor to measure conversation time for at least 9 days and an average of 31.3 days per year. Social behaviors were assessed through interviews, and the frequency of engagement in community activities, outings, lessons, or classes and contact frequency were assessed using a self-report questionnaire. The association between conversation time and social behavior was evaluated using multi-linear regression analysis.

Results

Conversation time was significantly associated with the frequency of engagement in community activities and lessons or classes after adjusting for several covariates (β = 0.181, 95% confidence interval: 0.107–0.254, p < 0.001; β = 0.11, 95% confidence interval: 0.04–0.179, p = 0.002).

Conclusion

Objectively measured conversation time using a wearable sensor is associated with social behavior and may be a valuable parameter for social isolation in older adults.
On-the-fly thermal expansion for Monte Carlo multi-physics reactor simulations
Authors: Imron Muhammad , Lee Deokjung
Published: October 2024

In this study, we present on-the-fly thermal expansion methodology for direct Monte Carlo coupled multi-physics reactor simulations. This approach allows the problem geometry to be thermally expanded on-the-fly during particle tracking using local temperatures, such as pin-averaged temperatures, obtained from the thermal-hydraulics solver. Numerical experiments demonstrated that modeling thermal expansion with local temperatures for thermal expansion improves the accuracy of reactor simulations, both for reactor eigenvalue and pin powers, compared to using global core-averaged temperatures. Additionally, the use of thermal expansion also improves the isothermal temperature coefficients, making them approximately 0.77 pcm/K closer to the measured data. Finally, results for depletion problems showed that incorporating thermal expansion in direct reactor modeling enhances the predicted critical boron concentration, particularly at high power and higher fuel burnup. These findings suggest that including thermal expansion in reactor modeling is essential for improving the fidelity of simulations.
Genetic diversity, population structure, and a genome-wide association study of sorghum lines assembled for breeding in Uganda
Authors: Kasule Faizo , Alladassi Boris M. E. , Aru Charles John , Adikini Scovia , Biruma Moses , Ugen Michael Adrogu , Kakeeto Ronald , Esuma Williams
Published: October 2024

Sorghum is an important source of food and feed worldwide. Developing sorghum core germplasm collections improves our understanding of the evolution and exploitation of genetic diversity in breeding programs. Despite its significance, the characterization of the genetic diversity of local germplasm pools and the identification of genomic loci underlying the variation of critical agronomic traits in sorghum remains limited in most African countries, including Uganda. In this study, we evaluated a collection of 543 sorghum accessions actively used in Ugandan breeding program across two cropping seasons at NaSARRI, Uganda, under natural field conditions. Phenotypic data analysis revealed significant (p<0.01) variation among accessions for days to 50% flowering, plant height, panicle exsertion, and grain yield, with broad-sense heritability (H²) estimates of 0.54, 0.9, 0.81, and 0.48, respectively, indicating a high genetic variability for these traits. We used a newly developed genomic resource of 7,156 single nucleotide polymorphism (SNP) markers to characterize the genetic diversity and population structure of this collection. On average, the SNP markers exhibited moderately high polymorphic information content (PIC = 0.3) and gene diversity (He = 0.3), while observed heterozygosity (Ho = 0.07) was low, typical for self-pollinating crops like sorghum. Admixture-based models, PCA, and cluster analysis all grouped the accessions into two subpopulations with relatively low genetic differentiation. Genome-wide association study (GWAS) identified candidate genes linked to key agronomic traits using a breeding diversity panel from Uganda. GWAS analysis using three different mixed models identified 12 genomic regions associated with days to flowering, plant height, panicle exsertion, grain yield, and glume coverage. Five core candidate genes were co-localized with these significant SNPs. The SNP markers and candidate genes discovered provide valuable insights into the genetic regulation of key agronomic traits and, upon validation, hold promise for genomics-driven breeding strategies in Uganda.
Interoceptive sensibility and alcohol craving in Polish prisoners: the role of alexithymia and emotional dysregulation
Authors: Ścigała Dawid Konrad , Fabris Matteo Angelo , Zdankiewicz-Ścigała Elżbieta , Kuc Krystian , Longobardi Claudio
Published: October 2024

Introduction

Alcohol craving, characterized by a strong desire or compulsion to consume alcohol, is a prominent symptom of substance dependence syndrome. Research indicates that alcohol craving is a significant factor leading to the termination of abstinence. The mechanisms underlying the activation of alcohol craving remain not fully understood. The urge to reach for alcohol may be stimulated by emotions, memories, thoughts, or bodily sensations, as well as external factors. It has been postulated that individuals with high levels of interoceptive sensibility tend to exhibit a high degree of alexithymia and emotion dysregulation in the context of alcohol craving. Deficits in identifying and verbalizing emotions, along with an operational thinking style, facilitate alcohol consumption by impeding accurate insight into one’s mental state, thereby hindering the comprehension of bodily states, emotions, and the regulation of self.

Method

This study involved 160 inmates incarcerated in a prison in Poland, awaiting participation in therapy for individuals with substance dependence following psychiatric diagnosis. Four questionnaires were used in the study: multidimensional Assessment of Interoceptive Sensibility (MAIA) for interoceptive sensibility, Toronto Alexithymia Scale (TAS-20) for alexithymia, Difficulties in Emotion Regulation Scale (DERS) for emotional dysregulation, and the Penn Alcohol Craving Scale (PACS) for alcohol craving assessment.

Results

The results of the study are as follows: the study findings indicated that alexithymia and emotional dysregulation significantly mediates the relationship between interoceptive sensibility and alcohol craving. The indirect effect for both factors was found to be significant, similar to the indirect effect observed for alexithymia as an mediator. However, in the case of emotional dysregulation, no significant indirect effect was observed.

Conclusion

Our study provides insights into the potential contribution of interoceptive sensibility to the heightened risk of alcohol dependence. Specifically, impaired interoceptive sensibility may be associated with the development of alexithymia and emotional dysregulation, potentially rendering individuals more susceptible to alcohol craving. Interoceptive sensibility could serve as a prerequisite for the cultivation of positive emotional processing skills.
An empirical study on the relationship between emotional labor and work performance among university teachers
Authors: Hao Danna
Published: October 2024

This study is based on the theory of emotional events and explores the relationship between emotional labor and the job performance of university teachers. Relevant data was obtained through a questionnaire, and a structural equation model was constructed for path analysis. The study found that the surface performance of university teachers has a significant negative impact on relationship performance and task performance; deep performance and proactive authenticity of university teachers have a significant positive impact on relationship performance, task performance, and adaptability performance, respectively; the passive reality of university teachers has a significant negative impact on relationship performance, task performance, and adaptability performance. Based on research findings, this study proposes suggestions for the performance evaluation mechanism of university teachers, including improving the recruitment methods, increasing the emotional labor assessment and incentive mechanism, focusing on alleviating negative emotions of teachers, strengthening the awareness guidance and education of school management and teachers on emotional labor, establishing training courses on emotional labor for teachers, arranging various activities reasonably, and creating a good working atmosphere. Ultimately, these suggestions aim to help university teachers recognize the significance of emotional labor, promote their educational and teaching work, and provide new methods and paths for improving the work performance of university teachers.
Benefits of exercise for children and adolescents with autism spectrum disorder: a systematic review and meta-analysis
Authors: Jia Mingyuan , Zhang Jia , Pan Jianhua , Hu Fengting , Zhu Zhipeng
Published: October 2024

Background

Numerous experimental studies have shown that exercise can serve as an intervention with beneficial effects on children and adolescents with autism. However, a systematic review on the specific areas affected has not been conducted.

Methods

Preliminary research sources were obtained by searching four databases, and two researchers independently screened the literature that met the study criteria. The study was conducted under the guidelines of the Cochrane Handbook for Systematic Reviews of Interventions.

Results

37 studies were included in the final analysis, of which 9 studies were quantitatively synthesized and 28 studies were qualitatively analyzed. Exercise interventions have positive effects on motor performance, cognitive function, individual and social relationships, behavioral problems, physical health, and brain function in children and adolescents with autism. The results of the meta-analysis indicate that exercise can effectively improve social skills [SMD=-0.53, 95%CI (-0.76, -0.3), P=0.000].

Conclusions

Long-term, regular, chronic exercise is beneficial for children and adolescents with autism, particularly in the area of social skills.

Systematic review registration

https://www.crd.york.ac.uk/prospero PROSPERO, identifier CRD42024554530.
Sleep deprivation-induced memory impairment: exploring potential interventions
Authors: Fan Yisheng , Li Jianfeng , Qiao Shanfeng
Published: October 2024

Sleep’s crucial role in memory consolidation is well-established, with neuroimaging and sleep stage analysis revealing the intricate processes involved. Sleep deprivation significantly impairs memory performance and the ability to form new memories, highlighting the need for effective countermeasures. This article concludes that while sleep deprivation significantly impairs memory, the emerging insights into the gut-brain axis offer a promising frontier for developing novel interventions that can mitigate these effects. The review discusses various interventions, ranging from pharmaceutical compounds like donepezil, memantine, and tolcapone, to innovative physical therapy techniques such as transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), and transcranial direct current stimulation (tDCS). Additionally, the emerging role of the gut-brain axis in sleep deprivation-induced memory impairment is examined, shedding light on the complex interplay between gut microbiota and cognitive functions. This comprehensive review explores the multifaceted relationship between sleep deprivation and memory impairment, delving into the neurobiological mechanisms underlying these processes and examining potential interventions.
Interferometry of ionospheric E-region irregularities based on Kunming VHF radars
Authors: Chen Bo , Xu Yihao , Zhou Chen , Zhang Yuqiang , Liu Yi , Xu Tong , Xu Bin , Feng Jian , Lan Ting , Qing Haiyin , Deng Zhongxin , Wang Xiang , Zhang Xinmiao
Published: October 2024

There is a long history of using VHF radar systems to detect ionospheric irregularities based on the theory of coherent scattering. According to previous work, there is a high occurrence of field-aligned irregularities (FAIs) in the ionospheric E-region over Kunming, China. In this paper, the VHF coherent scattering radar at Kunming is used to study the FAIs in the ionospheric E-region. Different arrangement of VHF radar antenna arrays, interferometry, and FAI echo parameter inversion methods are designed and tested. The measurement results show that the temporal and spatial characteristics of the irregularities can be obtained using these methods, as well as more refined spatial three-dimensional structure information. It is indicated that the new arrangement of the VHF radar antenna array is feasible to operate interferometry detection of E-region FAIs with the Kunming VHF radar.
Association Between Disability and Suicide Mortality in the Spanish Community-Dwelling Adult Population. A Population-Based Follow-Up Study
Authors: Pastor-Barriuso Roberto , Padrón-Monedero Alicia , Almazán-Isla Javier , García López Fernando J. , de Pedro-Cuesta Jesús , Damián Javier
Published: October 2024

Objectives

To assess the association of disability with suicide mortality, separately for women and men by age group.

Methods

Information was obtained from a representative national sample of 161,809 community-dwelling adults (≥18 years). Participants contributed to follow-up time from baseline interview (2008) until suicide, death by other causes, or 2017. We calculated, by sex, standardized suicide mortality differences (SSMD), comparing persons with and without disabilities standardized to sociodemographic distribution of disability population.

Results

29 women died by suicide during 800,754 person-years follow-up and 97 men during 735,709 person-years. Among women with disabilities, SSMD (95% Confidence interval) per 100,000 person-years at 5 years was 54.4 deaths (−17.2 to 126.1) [100.0 (−27.4 to 227.4) in women <65 years and −4.8 (−27.3 to 17.7) in women ≥65 years (P homogeneity = 0.11)]. Among men, SSMD increased by 122.2 deaths (4.1 to 240.3) [37.2 (−40.2 to 114.6) in men <65 years and 74.7 (−51.8 to 200.5) in men ≥65 years (P homogeneity = 0.62)].

Conclusion

Suicide risk was higher in women and men with disability. In women higher risk was only notable for those <65. Men presented similar effects in both age groups. Nevertheless, due to imprecision of estimates, results should be viewed cautiously.
Study on Flexural Performance of Reinforced Concrete Beams Strengthened with FRP Grid–PCM Composite Reinforcement
Authors: Zhang Zhimei , Qin Haixue
Published: October 2024

To study the flexural performance of fiber-reinforced polymer (FRP) grid–polymer cement mortar (PCM)-composite-strengthened RC beams, the finite element numerical simulation of FRP grid–PCM composite RC beams is carried out using ABAQUS to analyze the effects of the amount of FRP grid reinforcement, the type of FRP grid material, and the geometry of FRP grid on the flexural performance of reinforced concrete beams and to establish the flexural capacity calculation formula of FRP grid–PCM-reinforced RC beams in case of debonding failure, based on analysis of the influencing factors. The results show that increasing the reinforcement of the FRP grid and increasing the stiffness of the FRP grid can improve the flexural bearing capacity of RC beams, and the change of FRP grid geometry has little effect on the flexural bearing capacity of RC beams. The established formula for calculating the flexural bearing capacity of FRP grid-reinforced concrete beams can better predict the flexural capacity of reinforced concrete beams under peeling failure.
Improved PEG-Based Construction of Analog Fountain Codes
Authors: Li Xue , Huang Qin
Published: October 2024

This paper proposes an improved progressive edge-growth (PEG) construction of analog fountain codes (AFCs). During edge selection, it simultaneously allocates weight coefficients in descending order. Analysis shows that our proposed construction reduces the probability of large weight coefficients involved in harmful short cycles. Simulation results indicate that it has good block error rate (BLER) in short block length regime.
Energy Security and Women’s Empowerment: A Generalized Method of Moments Approach from a Global Perspective
Authors: Sarabdeen Masahina , Kijas A. C. Muhammadu , Mabrouk Fatma , Binsuwadan Jawaher , Almugren Hawazen Zam
Published: October 2024

The importance of energy security is emphasized in Goal 7 of the 17 Sustainable Development Goals (SDGs) of the 2030 Agenda to guarantee that everyone has affordable, dependable, and contemporary energy access. In addition to transforming human life, whole economies, and even the planet, sustainable energy offers a chance for a better future. The absence of energy security impacts serious health problems, education, and household difficulties. Research on energy security has emphasized various angles worldwide. However, investigations of the impact of energy security on women’s empowerment are still scant. This study thus investigates the relationship between energy security and women’s empowerment (WE) in 167 countries from 2002 to 2021, as well as the influence of urbanization development levels on this nexus. Moreover, this study explores the variation in women’s empowerment between geographical regions by referencing the MENA, OECD, and SAARC countries. A two-step system GMM was used to achieve the objectives of this research. The findings show first that renewable energy availability has a significant effect on WE worldwide. Secondly, in terms of energy security, the variables total availability of natural resource rents and renewable energy both have a positive impact on women’s empowerment in the MENA, while in the OECD and SAARC countries, they have an indirect link with WE. Third, the integrating effect of total natural resource rents with urbanization significantly affects WE in all five models. Fourth, we used access to electricity to represent resource affordability. Unexpectedly, the results show its negative and significant association with WE. Fifth, in terms of energy security, both energy availability and affordability favor WE in OECD countries. Finally, the coefficient of integration of access to electricity and urbanization shows a positive and significant association with WE in the OECD, MENA, and SAARC regions. However, it is noteworthy to mention that access to electricity alone does not influence WE worldwide. Additionally, a series of tests confirm the robustness of the results. This research provides insight into the development and implications of energy security-related women’s empowerment policies.
Enhancing Energy Systems and Rural Communities through a System of Systems Approach: A Comprehensive Review
Authors: Soussi Abdellatif , Zero Enrico , Bozzi Alessandro , Sacile Roberto
Published: October 2024

Today’s increasingly complex energy systems require innovative approaches to integrate and optimize different energy sources and technologies. In this paper, we explore the system of systems (SoS) approach, which provides a comprehensive framework for improving energy systems’ interoperability, efficiency, and resilience. By examining recent advances in various sectors, including photovoltaic systems, electric vehicles, energy storage, renewable energy, smart cities, and rural communities, this study highlights the essential role of SoSs in addressing the challenges of the energy transition. The principal areas of interest include the integration of advanced control algorithms and machine learning techniques and the development of robust communication networks to manage interactions between interconnected subsystems. This study also identifies significant challenges associated with large-scale SoS implementation, such as real-time data processing, decision-making complexity, and the need for harmonized regulatory frameworks. This study outlines future directions for improving the intelligence and autonomy of energy subsystems, which are essential for achieving a sustainable, resilient, and adaptive energy infrastructure.
The Low-Carbon Path of Active Distribution Networks: A Two-Stage Model from Day-Ahead Reconfiguration to Real-Time Optimization
Authors: Jia Taorong , Yang Guoqing , Yao Lixiao
Published: October 2024

The integration of renewable energy sources and distributed energy storage systems increasingly complicates the operation of distribution networks, while stringent carbon reduction targets demand low-carbon operational strategies. To address these complexities, this paper introduces a two-stage model for reconfiguring distribution networks and ensuring low-carbon dispatch. Initially, second-order cone programming is employed to minimize losses in the network. Subsequently, the outputs of renewable energy and energy storage systems are optimized using the mantis search algorithm (MSA) to achieve low-carbon dispatch, with the network’s carbon potential as the evaluation metric. The proposed model demonstrates a significant reduction in average active power loss by 34.85%, a decrease in daily carbon emissions by 509.97 kg, and a reduction in carbon emission costs by 17.24%, thereby markedly enhancing the economic and social benefits of grid operations.
On the Use of the Multi-Site Langmuir Model for Predicting Methane Adsorption on Shale
Authors: Wu Zhe , Ji Yuan , Zhang Ke , Jing Li , Zhao Tianyi
Published: October 2024

Shale gas, mainly consisting of adsorbed gas and free gas, has served a critical role of supplying the growing global natural gas demand in the past decades. Considering that the adsorbed methane has contributed up to 80% of the total gas in place (GIP), understanding the methane adsorption behaviors is imperative to an accurate estimation of total GIP. Historically, the single-site Langmuir model, with the assumption of a homogeneous surface, is commonly applied to estimate the adsorbed gas amount. However, this assumption cannot depict the methane adsorption characteristics due to various compositions and pore sizes of shales. In this work, a multi-site model integrating the energetic heterogeneity in adsorption is derived to predict methane adsorption on shale. Our results show that the multi-site model is capable of addressing the heterogeneity of shales by a wide range of adsorption energy distributions (owing to the complex compositions and different pore sizes), which is different from the single-site model only characterized by single adsorption energy. Consequently, the multi-site model results have better accuracy against the experimental data. Therefore, applying the multi-site Langmuir model for estimating GIP in shales can achieve more accurate results compared with using the traditionally single-site model.
Energy Flux Method for Wave Energy Converters
Authors: Scarlett Gabriel Thomas , McNatt James Cameron , Henry Alan , Arredondo-Galeana Abel
Published: October 2024

Hydrodynamic tools reveal information as to the behaviour of a device in the presence of waves but provide little information on how to improve or optimise the device. With no recent work on the transfer of power (energy flux) from a wave field through the body surface of a wave energy converter (WEC), we introduce the energy flux method to map the flow of power. The method is used to develop an open-source tool to visualise the energy flux density on a WEC body surface. This energy flux surface can also be used to compute the total power capture by integrating over the surface. We apply the tool to three WEC classes: a heaving cylinder, a twin-hulled hinged barge, and pitching surge devices. Using the flux surfaces, we investigate power efficiency in terms of power absorbed to power radiated. We visualise the hydrodynamic consequence of sub-optimal damping. Then, for two pitching surge devices with similar resonant peaks, we reveal why one device has a reduced power performance in a wave spectrum compared to the other. The results show the effectiveness of the energy flux method to predict power capture compared to motion-based methods and highlight the importance of assessing the flux of energy in WECs subjected to different damping strategies. Importantly, the tool can be adopted for a wide range of applications, from geometry optimisation and hydrodynamic efficiency assessment to structural design.
Numerical Investigation of Wind Turbine Airfoil Icing and Its Influencing Factors under Mixed-Phase Conditions
Authors: Wang Xiang , Ru Yiyao , Zhao Huanyu , Wang Zhengzhi
Published: October 2024

Icing is a popular research area in wind energy, and the icing problem of the supercooled droplet–ice crystal mixed-phase condition is one of the new challenges. A numerical method for analyzing the icing characteristics of wind turbine airfoil under mixed-phase conditions is presented. The control equations for the dynamics of supercooled droplets and ice crystals are formulated using the Lagrangian method. Equations for the conservation of mass and energy during the icing process involving supercooled droplets and ice crystals are constructed. The impact of erosion phenomena on the mixed-phase icing process is examined, and methodologies for solving the control equations are introduced. The numerical method is utilized for modeling mixed-phase icing under a range of conditions. The results of these simulations are then compared with data obtained from icing wind tunnel tests to assess the validity of the method. The influence of various mixed-phase conditions on ice shapes is studied. It is found that higher icing temperatures correspond to a larger icing range and amount. The increase in supercooled droplet content, ice crystal content, and ice crystal diameter all contribute to enhanced ice accretion. However, the effects of ice crystal content and diameter are relatively minor.
Methyl Jasmonate (MeJA) Promotes the Self-Pollen Tube Growth of Camellia oleifera by Regulating Lignin Biosynthesis
Authors: Chang Yihong , Guo Xinmiao , Xu Honggang , Wu Qixiao , Xie Anqi , Zhao Zhixuan , Tian Ruijie , Gong Wenfang , Yuan Deyi
Published: October 2024

Self-incompatibility (SI) poses a significant reproductive barrier, severely impacting the yield, quality, and economic value of Camellia oleifera. In this study, methyl jasmonate (MeJA) was employed as an exogenous stimulus to alleviate SI in C. oleifera. The research findings revealed that an exogenous dose of 1000 μmol·L−1 MeJA enhanced the germination and tube growth of C. oleifera self-pollen and greatly improved ovule penetration (18.75%) and fertilization (15.81%), ultimately increasing fruit setting (18.67%). It was discovered by transcriptome analysis that the key genes (CAD, C4H) involved in the lignin production process exhibited elevated expression levels in self-pistils treated with MeJA. Further analysis showed that the lignin concentration in the MeJA-treated pistils was 31.70% higher compared with the control group. As verified by pollen germination assays in vitro, lignin in the appropriate concentration range could promote pollen tube growth. Gene expression network analysis indicated that transcription factor bHLH may be pivotal in regulating lignin biosynthesis in response to MeJA, which in turn affects pollen tubes. Further transient knockdown of bHLH (Co_33962) confirmed its important role in C. oleifera pollen tube growth. In summary, the application of MeJA resulted in the stimulation of self-pollen tube elongation and enhanced fruit setting in C. oleifera, which could be associated with the differential change in genes related to lignin synthesis and the increased lignin content.
Perivascular Adipose Tissue Becomes Pro-Contractile and Remodels in an IL10−/− Colitis Model of Inflammatory Bowel Disease
Authors: Jenkins Samuel W. , Grunz Elizabeth A. , Ramos Kassandra R. , Boerman Erika M.
Published: October 2024

Inflammatory Bowel Diseases (IBDs) are associated with aberrant immune function, widespread inflammation, and altered intestinal blood flow. Perivascular adipose tissue (PVAT) surrounding the mesenteric vasculature can modulate vascular function and control the local immune cell population, but its structure and function have never been investigated in IBD. We used an IL10−/− mouse model of colitis that shares features with human IBD to test the hypothesis that IBD is associated with (1) impaired ability of PVAT to dilate mesenteric arteries and (2) changes in PVAT resident adipocyte and immune cell populations. Pressure myography and electrical field stimulation of isolated mesenteric arteries show that PVAT not only loses its anti-contractile effect but becomes pro-contractile in IBD. Quantitative immunohistochemistry and confocal imaging studies found significant adipocyte hyperplasia and increased PVAT leukocytes, particularly macrophages, in IBD. PCR arrays suggest that these changes occur alongside the altered cytokine and chemokine gene expression associated with altered NF-κB signaling. Collectively, these results show that the accumulation of macrophages in PVAT during IBD pathogenesis may lead to local inflammation, which ultimately contributes to increased arterial constriction and decreased intestinal blood flow with IBD.
Biochemistry and Diseases Related to the Interconversion of Phosphatidylcholine, Phosphatidylethanolamine, and Phosphatidylserine
Authors: Korbecki Jan , Bosiacki Mateusz , Kupnicka Patrycja , Barczak Katarzyna , Ziętek Paweł , Chlubek Dariusz , Baranowska-Bosiacka Irena
Published: October 2024

Phospholipids are crucial structural components of cells. Phosphatidylcholine and phosphatidylethanolamine (both synthesized via the Kennedy pathway) and phosphatidylserine undergo interconversion. The dysregulation of this process is implicated in various diseases. This paper discusses the role of enzymes involved in the interconversion of phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine, specifically phosphatidylethanolamine N-methyltransferase (PEMT), phosphatidylserine synthases (PTDSS1 and PTDSS2), and phosphatidylserine decarboxylase (PISD), with a focus on their biochemical properties. Additionally, we describe the effects of the deregulation of these enzymes and their roles in both oncological and non-oncological diseases, including nonalcoholic fatty liver disease (NAFLD), Alzheimer’s disease, obesity, insulin resistance, and type II diabetes. Current knowledge on inhibitors of these enzymes as potential therapeutic agents is also reviewed, although in most cases, inhibitors are yet to be developed. The final section of this article presents a bioinformatic analysis using the GEPIA portal to explore the significance of these enzymes in cancer processes.
Current Overview of Spinocerebellar Ataxia Type 7 in Mexican Population: Challenges in Specialized Care for a Rare Disease
Authors: Cerecedo-Zapata César M. , Tapia-Guerrero Yessica S. , Ramírez-González José A. , Meza-Dorantes Aranza , Tercero-Pérez Karla N. , Cortés Hernán , Guerra-Grajeda Araceli , Ortega-Ibarra Ilse H. , Gatica-Ramos Gabriela , Poblete-Velazquez Alfredo , Leyva-García Norberto , Velázquez-Pérez Luis , Cisneros Bulmaro , Magaña Jonathan J.
Published: October 2024

Spinocerebellar ataxia type 7 (SCA7) is a rare genetic disease characterized by progressive cerebellar syndrome and macular degeneration. In a previous study, we clinically and genetically characterized a group of Mexican patients, which represented one of the largest cohorts of SCA7 patients worldwide and demonstrated that all patients had a unique genetic origin. Our laboratory developed a program for the diagnosis, medical care, and long-term follow-up of these patients living in Veracruz State, and in this report, we present an update to this research, covering 2013 to 2024. So far, we identified 172 SCA7 carriers, with a few cases outside Veracruz, and our data support that the length of the CAG repeat tract mainly determines disease severity and life expectancy, and accordingly, we define three different phenotypes, early-onset (EO), classical-onset (CO), and late-onset (LO), with EO patients showing the lowest life expectancy. Furthermore, we found that parental transmission of mutant alleles leads to increased CAG repeat instability, compared to maternal ones. Interestingly, a haplotype analysis revealed that patients outside Veracruz may have different genetic origins. In conclusion, longitudinal observations of SCA7 patients provide insight into the natural history of SCA7 and help to design strategies for diagnosis, genetic counseling, physical rehabilitation, and therapeutic alternatives.
Genome-Wide Profiling of the ACTIN Gene Family and Its Implications for Agronomic Traits in Brassica napus: A Bioinformatics Study
Authors: Yao Shengli , Peng Jiayu , Hu Ming , Zhou Qing , Zhao Xiuju
Published: October 2024

ACTINs are key structural proteins in plants, which form the actin cytoskeleton and are engaged in numerous routine cellular processes. Meanwhile, ACTIN, recognized as a housekeeping gene, has not yet been thoroughly investigated in Brassica napus. The current research has led to the detection of 69 actin genes in B. napus, which were organized into six distinct subfamilies on the basis of phylogenetic relationships. Functional enrichment analysis, along with the construction of protein interaction networks, suggested that BnACTINs play roles in Preserving cell morphology and facilitating cytoplasmic movement, plant development, and adaptive responses to environmental stress. Moreover, the BnACTIN genes presented a wide range of expression levels among different tissues, whereas the majority experienced a substantial increase in expression when subjected to various abiotic stresses, demonstrating a pronounced sensitivity to abiotic factors. Furthermore, association mapping analysis indicated that some BnACTINs potentially affected certain key agronomic traits. Overall, our research deepens the knowledge of BnACTIN genes, promotes the cultivation of improved B. napus strains, and lays the groundwork for subsequent functional research.
Integrated Metabolomics and Transcriptomics Analyses Reveal the Regulatory Mechanisms of Anthocyanin and Carotenoid Accumulation in the Peel of Coffea arabica
Authors: Wang Zuquan , Xie Chun , Wu Yihong , Liu Haobo , Zhang Xuesong , Du Huabo , Li Xuejun , Zhang Chuanli
Published: October 2024

The color of coffee fruits is influenced by several factors, including cultivar, ripening stage, and metabolite composition. However, the metabolic accumulation of pigments and the molecular mechanisms underlying peel coloration during the ripening process of Coffea arabica L. remain relatively understudied. In this study, UPLC-MS/MS-based metabolomics and RNA sequencing (RNA-seq)-based transcriptomics were integrated to investigate the accumulation of anthocyanins and carotenoids in the peel of Coffea arabica at different ripening stages: green peel (GP), green-yellow peel (GYRP), red peel (RP), and red-purple peel (RPP). This integration aimed at elucidating the molecular mechanisms associated with these changes. A total of ten anthocyanins, six carotenoids, and thirty-five xanthophylls were identified throughout the ripening process. The results demonstrated a gradual decrease in the total carotenoid content in the peel with fruit maturation, while anthocyanin content increased significantly. Notably, the accumulation of specific anthocyanins was closely associated with the transition of peel colors from green to red. Integrated metabolomics and transcriptomics analyses identified the GYRP stage as critical for this color transition. A weighted gene co-expression network analysis (WGCNA) revealed that enzyme-coding genes such as 3AT, BZ1, and lcyE, along with transcription factors including MYB, NAC, and bHLH, which interact with PHD and SET TR, may regulate the biosynthesis of anthocyanins and carotenoids, thereby influencing peel pigmentation. These findings provide valuable insights into the molecular mechanisms underlying the accumulation of anthocyanins and carotenoids in Coffea arabica peel during fruit maturation.
Induced Necroptosis and Its Role in Cancer Immunotherapy
Authors: Zhang Ziyao , Zhang Fangming , Xie Wenjing , Niu Yubo , Wang Haonan , Li Guofeng , Zhao Lingyun , Wang Xing , Xie Wensheng
Published: October 2024

Necroptosis is a type of regulated cell death (RCD) that is triggered by changes in the extracellular or intracellular milieu that are picked up by certain death receptors. Thanks to its potent capacity to induce immunological responses and overcome apoptotic resistance, it has garnered significant attention as a potential cancer treatment. Basic information for the creation of nano-biomedical treatments is provided by studies on the mechanisms underlying tumor necroptosis. Receptor-interacting protein kinase 1 (RIPK1)–RIPK3-mediated necroptosis, Toll-like receptor domain-containing adapter-inducing interferon (IFN)-β (TRIF)–RIPK3-mediated necroptosis, Z-DNA-binding protein 1 (ZBP1)–RIPK3-mediated necroptosis, and IFNR-mediated necroptosis are the four signaling pathways that collectively account for triggered necroptosis in this review. Necroptosis has garnered significant interest as a possible cancer treatment strategy because, in contrast to apoptosis, it elicits immunological responses that are relevant to therapy. Thus, a thorough discussion is held on the connections between tumor cell necroptosis and the immune environment, cancer immunosurveillance, and cells such as dendritic cells (DCs), cytotoxic T cells, natural killer (NK) cells, natural killer T (NKT) cells, and their respective cytokines. Lastly, a summary of the most recent nanomedicines that cause necroptosis in order to cause immunogenic cell death is provided in order to emphasize their promise for cancer immunotherapy.
Advancements in Drug Delivery Systems for the Treatment of Sarcopenia: An Updated Overview
Authors: Najm Alfred , Moldoveanu Elena-Theodora , Niculescu Adelina-Gabriela , Grumezescu Alexandru Mihai , Beuran Mircea , Gaspar Bogdan Severus
Published: October 2024

Since sarcopenia is a progressive condition that leads to decreased muscle mass and function, especially in elderly people, it is a public health problem that requires attention from researchers. This review aims to highlight drug delivery systems that have a high and efficient therapeutic potential for sarcopenia. Current as well as future research needs to consider the barriers encountered in the realization of delivery systems, such as the route of administration, the interaction of the systems with the aggressive environment of the human body, the efficient delivery and loading of the systems with therapeutic agents, and the targeted delivery of therapeutic agents into the muscle tissue without creating undesirable adverse effects. Thus, this paper sets the framework of existing drug delivery possibilities for the treatment of sarcopenia, serving as an inception point for future interdisciplinary studies.
New Markers of Early Kidney Damage in Children and Adolescents with Simple Obesity
Authors: Medyńska Anna , Chrzanowska Joanna , Zubkiewicz-Kucharska Agnieszka , Zwolińska Danuta
Published: October 2024

The impact of obesity on kidney injury and the development of chronic kidney disease (CKD) is well documented. Unfortunately, the early stages of CKD are asymptomatic, leading to a delayed diagnosis and a worse prognosis. There is a need for more sensitive indicators of kidney damage than those currently used. We aimed to assess the usefulness of serum t-CAF, urinary netrin-1, α-GST, π-GST, calbindin, and calprotectin as biomarkers of early kidney damage in obese children and to investigate the relationship between these indicators and the degree of obesity. A total of 125 simple obese, normoalbuminuric children and 33 non-obese children as controls were selected. Patients were divided into 2 subgroups according to SDS BMI (I: 2 ≤ 4, II: >4). Serum t-CAF was significantly higher in the obese group compared to the controls, as were urinary α-GST, netrin-1, π-GST, and calprotectin. No difference was found between the two obese groups. In normoalbuminuric obese children and adolescents without significant metabolic disorders, serum t-CAF may be a new biomarker for the early detection of renal dysfunction, and urinary netrin-1, α-GST, π-GST, and calprotectin may be better indicators for the detection of early tubular damage, independent of the severity of obesity.
Enhanced Combustion Properties of Al-Si Eutectic Alloy in Energetic Mixtures
Authors: Ketegenov Tlek , Vongay Igor , Chervyakova Oksana , Kalmuratova Bakhyt , Kononov Anton , Kamunur Kaster , Nadirov Rashid
Published: October 2024

This study investigates the feasibility of using an Al-Si eutectic alloy as a reactive fuel in energetic mixtures. Al-Si eutectic alloy powders were obtained from secondary resources and ground to a particle size of less than 100 μm. We examined these powders’ burning characteristics and thermal properties compared to pure Al powder. Results showed that the burning rate of energetic mixtures containing Al-Si eutectic alloys was 1.5 to 2.0 mm/s higher than those with pure Al. Additionally, the activation energy of pure PTFE was reduced from 81.29 kJ/mol to 61.75 kJ/mol when the Al-Si alloy was added. The formation of oxides, carbides, and fluorides in the combustion products of Al-Si-based mixtures significantly influenced their thermodynamics.
Study on Microstructure and Texture of Fe-3%Si Ultra-Thin Ribbons Prepared by Planar Flow Casting
Authors: Xu Jiangjie , Zhang Ning , Tu Yang , Meng Li , Zhou Xiaozhou , Niu Chengzhou
Published: October 2024

In this paper, Fe-3%Si ultra-thin ribbons prepared by the planar flow casting (PFC) technique were subjected to temper rolling and annealing treatments. The microstructure and texture evolution during this process were examined through experimental measurements coupled with crystal plasticity finite element (CPFE) simulation to assess the feasibility of preparing ultra-thin non-oriented silicon steel using PFC ribbons. The results indicate that the PFC ribbons exhibit a significant columnar crystal structure, and {001}-oriented grains comprise over 30%. After being annealed, the grains with different orientations grew uniformly, the texture components were basically unchanged, and the {001} texture was well preserved. When annealing was carried out after temper rolling with a reduction rate of 7%, uneven grain growth was observed, and the growth tendency of the {001} grains, especially, surpassed that of the {111} grains, with an elevated temperature which peaked at 950 °C, where the proportion of {001} grains was maximal. When being annealed after temper rolling to 15%, grains of other orientations showed significant growth at each temperature, while the {001} grains did not show an obvious growth advantage. Utilizing the CPFE, the deformation-stored energy distribution of each characteristic-oriented grain was simulated, and it was shown that compared to the 15% rolling reduction rate, the deformation-stored energy accumulation of {001}-oriented grains after being rolled to 7% reduction was significantly lower than that of {111}-oriented grains. It suggests that the larger stored energy difference makes {001} grains show a stronger growth advantage based on the SIBM mechanism during annealing, after being rolled with a reduction rate of 7%. Overall, for the synergistic optimization of microstructure and texture, rolling with a 7% reduction rate followed by annealing at 950 °C in a hydrogen atmosphere is most advantageous.
Characterization of Silver Conductive Ink Screen-Printed Textile Circuits: Effects of Substrate, Mesh Density, and Overprinting
Authors: Im Hyobin , Roh Jung-Sim
Published: October 2024

This study explores the intricate interaction between the properties of textile substrates and screen-printing parameters in shaping fabric circuits using silver conductive ink. Via analyzing key variables such as fabric type, mesh density, and the number of overprinted layers, the research revealed how the porous structure, large surface area, and fiber morphology of textile substrates influence ink absorption, ultimately enhancing the electrical connectivity of the printed circuits. Notably, the hydrophilic cotton staple fibers fabric effectively absorbed the conductive ink into the fabric substrate, demonstrating superior electrical performance compared with the hydrophobic polyester filament fabric after three overprinting, unlike the results observed after a single print. As mesh density decreased and the number of prints increased, the electrical resistance of the circuit gradually reduced, but ink bleeding on the fabric surface became more pronounced. Cotton fabric, via absorbing the ink deeply, exhibited less surface bleeding, while polyester fabric showed more noticeable ink spreading. These findings provide valuable insights for improving screen printing technology for textile circuits and contribute to the development of advanced fabric circuits that enhance the functionality of smart wearable technology.
Expansion Control of Alkali-Activated Materials Using Waste Glass Cullet from Photovoltaic Panels as Fine Aggregates
Authors: Yamanouchi Ryo , Yasui Kentaro , Yamada Hiroshi , Fukunaga Takayuki , Harada Hideki
Published: October 2024

Glass cullet (GC) generated from the disposal of photovoltaic (PV) panels are typically landfilled, and effective GC utilization methods must be established for PV generation. In this study, alkali-activated material (AAM) mortars were prepared from the paste of fine blast-furnace slag powder, fly ash, and sodium orthosilicate (SO) and mixed with crushed sand and GC to investigate the potential use of GC as a fine aggregate in AAM. The replacement of crushed sand with GC did not considerably affect the flowability of the mortar, whereas the compressive strength decreased with the increasing GC replacement rates. Although expansion due to the alkali–silica reaction (ASR) was observed in mortars wherein GC replaced crushed sand, the expansion can be controlled by reducing the amount of mixed SO, autoclaving the GC, performing preleaching to remove the Si that causes the ASR, and replacing the blast-furnace slag with fly ash. By enforcing measures against the expansion, the possibility of using GC as fine aggregate is enhanced considerably, thus increasing the feasibility of continuous PV production.
Godeaux and Campedelli Surfaces via Deformations
Authors: Wali Haseeb , Iqbal Sohail
Published: October 2024

In this paper, we construct two deformations of the Godeaux surface with π1≅Z4, such that each central fibre contains a family of conics. We show that surfaces that are birational to these Godeaux surfaces exist in two connected components of the moduli space of the Campedelli surfaces with a fundamental group of order 8. The whole construction is simplified by the use of key varieties.