bluuebunny/crossref_metadata_2025 huggingface dataset:
Un solo corazón. La tragedia de Alianza Lima y la solidaridad del Colo Colo
Authors: Panfichi Aldo
Published: April 2023

Los académicos hemos estudiado cómo el impacto emocional de la tragedia de Alianza Lima, en el contexto político y social de fines de los años ochenta, dio lugar a la construcción de historias y fantasías populares que trataban de darle algún sentido a la absurda desaparición de un grupo de jugadores jóvenes talentosos y crecientemente idolatrados. La prensa por su lado ha publicado numerosas crónicas que revelan las deficiencias organizacionales del transporte aéreo y de los clubes como factores que confluyeron en el fatal desenlace. Incluso desde el teatro y la literatura se han intentado recreaciones que muestran los dramas personales y familiares presentes en la tragedia. La filmación de una película se anuncia con el mismo fin.
Hermanos en el trabajo : el internacionalismo del movimiento social tarapaqueño en la huelga y masacre obrera de 1907
Authors: Artaza Barrios Pablo
Published: April 2023

Las fuertes tensiones y desavenencias registradas entre los Estados chileno y peruano son de larga data y públicamente conocidas, ya que se remontan a sus respectivos procesos de constitución como Estado-nación. Inmersos en ellos, durante el siglo XIX la definición de sus territorios y fronteras recurrió a los conflictos bélicos, mecanismo que prolongó las consecuencias políticas, territoriales, sociales y económicas y se proyecta hasta la actualidad.
Conferencia magistral : el contexto en el análisis politológico
Authors: Nohlen Dieter
Published: April 2023

El contexto como intervalo temporal a ser materia de estudio abarca condiciones generales de la investigación en ciencias sociales que influyen o pueden influir tanto en el diseño como en el proceso y el resultado de una investigación. Por ello, generando o aplicando teorías, el contexto puede marcar la diferencia respecto al efecto que la variable independiente en el marco de una relación causal tiene sobre la dependiente, y por ende el efecto que exhibe en un caso puede variar en otro. Sin embargo, aplicando el conocimiento generalizado sobre los efectos que ejercen determinadas variables en casos disímiles, el contexto puede explicar, tal vez, por qué se afirma una teoría en algunos casos y en otros no.
Sistema de partidos : diagnóstico, análisis y propuestas de reforma en el sistema de partidos
Authors: Campos Milagros , Corvetto Piero , Jaime Wilson , Mujica Jarís , Velasco Otoniel
Published: April 2023

La existencia de partidos sólidos, institucionalizados, eficientes y democráticos es vital para el funcionamiento de la democracia representativa en el Perú. Los partidos políticos tienen serias dificultades para ser verdaderos canales de participación. Aparecen ante la ciudadanía como organizaciones ineficientes, informales, antidemocráticas y hasta corruptas, en el contexto de una cultura política anti partido y de una falta de continuidad institucional así como un sistema de partidos no institucionalizado y muy fragmentado.
Panel : Rafael Roncagliolo, Dieter Nohlen, Henry Pease
Authors: Roncagliolo Rafael
Published: April 2023

Observaciones en función de los aportes desarrollados por los alumnos del doctorado.
La democracia en debate: el Estado y la democracia en América Latina
Authors: Pease Henry , López Sinesio , Ames Rolando , Nohlen Dieter
Published: April 2023

En este último capítulo vamos a intentar un balance general de todo el libro como reflejo de lo que se desarrolló en el VI Seminario Reforma del Estado 2010.
Relatoría : Doctorado Honoris Causa al Profesor Dieter Nohlen
Authors: Ortiz René , Ames Rolando , Tuesta Fernando , González de Olarte Efraín , Nohlen Dieter
Published: April 2023

La Pontifica Universidad Católica del Perú celebra el presente acto académico en el que se entregará formal y solemnemente, al reconocido especialista en ciencia política Dr. Dieter Nohlen, las insignias que lo distinguirán en adelante como Doctor Honoris Causa de nuestra casa de estudios. Procederemos en seguida a la lectura de la resolución de Consejo Universitario que confiere la distinción.
Relato aparente
Authors: Fernández Carrera Gastón
Published: April 2023

Quienes conocimos a Gastón Fernández, y fuimos lectores primeros de sus Relatos aparentes, lo supimos inteligente y angustiado. Esa prosa suya (hecha para la relegada expresión filosófica, que nunca quiso compartir abiertamente con los lujos literarios) fue siempre, desde su hora primera, la de un lenguaje ardorosamente trabajado con pasión fervorosa.
Eliana y El Tigre del Sur
Authors: Calderón Fajardo Carlos
Published: April 2023

Los ochentas nos ofrecen temáticas y discursos diversos, que se enriquecen en su propia variedad y que serán una marca para la generación siguiente. Aquí tenemos cuentistas notables como Fernando Ampuero, Carlos Calderón Fajardo, Alonso Cueto, Mariella Sala, Guillermo Niño de Guzmán, Alejandro Sánchez Aizcorbe, Dante Castro y Pilar Dughi.
La noche del poeta
Authors: Pollarolo Giovanna
Published: April 2023

En la última década del siglo XX, vemos como poetas de generaciones anteriores incursionan en la narrativa con un discurso propio y muy bien estructurado. Así, entre los antologados; podemos mencionar a Giovanna Pollarolo y Rocío Silva, Santisteban.
La otra
Authors: Cueto Alonso
Published: April 2023

Un conjunto de buenas lecturas (y no solamente de lengua espafi.ola) respalda la buena prosa de Alonso Cueto, que la maneja con la soltura de quien frecuenta los lujos del lenguaje cinematogrMico.
Good morning, heartache
Authors: Niño de Guzmán Guillermo
Published: April 2023

En este cuadro debe celebrarse la convocatoria imaginativa a que nos invita la prosa de Niño de Guzmán.
Muñequita linda
Authors: Ninapayta Jorge
Published: April 2023

Los jóvenes narradores, asimismo, han podido nutrirse de diversas tradiciones narrativas, tanto peruanas como extranjeras; moverse incluso en otros géneros, enriqueciendo aún más la narrativa peruana. Como casos paradig, máticos podemos citar a Enrique Prochazka, Jorge Ninapayta, Fernando lwasaki e lván Thays, con quienes se cierra esta antología.
El limpiador
Authors: Silva Santisteban Rocío
Published: April 2023

Breve, pero significativa, es la contribución de la prosa femenina. Ese cincelado lenguaje de Rocío Silva Santisteban nos propicia un texto de perfilado realismo y asegura a su prosa adecuado perfil.
¿Nativos digitales? Percepción de habilidades en niños y niñas de zonas rurales
Authors: Pavez Isabel
Published: April 2023

Los niños de zonas rurales se han enfrentado históricamente a severas desventajas tanto en el ámbito educativo como en el digital. La pandemia de COVID-19 ha sido un recordatorio de las barreras que deben sortear debido a la inestable señal de internet, carencias de dispositivos y habilidades digitales. Por ello este trabajo discute el concepto de nativos digitales, es decir, la creencia de que los menores de edad, independiente de sus circunstancias, gozan de habilidades digitales que les permite hacer uso de internet sin necesidad de guías o instrucción previa. Desde una perspectiva cualitativa se analizan discursos y construcciones sociales sobre el rol de internet en la vida diaria a niños de entre 11 y 12 años, a través de la entrevista en tríadas a los menores, sus madres y profesores jefes, además de los directivos de escuelas en cuatro localidades rurales en Chile durante el segundo año de la pandemia. Los principales hallazgos muestran que, a pesar de ser parte de un grupo desfavorecido y la precariedad de la conexión a internet, todos los participantes tienen acceso a teléfonos inteligentes desde una edad temprana. No obstante, los adultos de su entorno educativo tienden a coincidir que el escaso desarrollo de habilidades digitales obstaculiza su proceso de aprendizaje remoto, a pesar de que los niños presentan confianza en el uso de dispositivos.
Adaçayı (Salvia sp.) (Lamiaceae) Türlerine Ait Uçucu Yağların Bazı Depolanmış Ürün Zararlılarına Karşı Fumigant Etkilerinin Araştırılması
Authors: YİĞİT Nazlı , GÖZÜAÇIK Celalettin , GÜLTEKİN Levent
Published: April 2023

Bu çalışmada, Iğdır ilinden toplanan Lamiaceae familyasına ait Salvia hydrangea DC. ex Bentham, Salvia verticillata L. subsp. amasiaca (Freyn. & Bornm.) Bornm. ve Salvia nemorosa L. bitkilerinin toprak üstü aksamlarından elde edilen uçucu yağların depolanmış ürünlerde önemli zararlılar olan Rhyzopertha dominica (Fabricius, 1792), Oryzaephilus surinamensis (Linnaeus, 1758), Cryptolestes ferrugineus (Stephens, 1831), Tribolium confusum Jacquelin du Val, 1861 ve Callosobruchus maculatus (Fabricius, 1775)’un ergin dönemlerine karşı fumigant etkileri incelenmiştir. Salvia türlerinden elde edilen uçucu yağlar 25 ± 1 ºC sıcaklık ve % 65 ± 5 orantılı nem koşullarında 5, 10 ve 15 μl Petri-1 dozlarda 3 tekerrür olarak hazırlanmış ve 12, 24, 48, 72 ve 96 saatte ölüm oranlarına bakılarak LC50 ve LC90 değerleri belirlenmiştir. Çalışmalar sonucunda Salvia türlerinden elde edilen uçucu yağların toksisite seviyeleri böceğin ve bitkinin türüne, uygulanan konsantrasyona ve uygulama sonrası geçen zamana bağlı olarak değişmiş ve en yüksek etkiyi S. hydrangea’den elde edilen uçucu yağ göstermiştir.
Ilgaz Dağı Milli Parkı Doğal Çam Orman Arazilerinin Çölleşme Risk Değerlendirmesinde Bulanık-AHP Yaklaşımı ve Yapay Zekâ Kullanımı
Authors: DENGİZ Orhan , SAFLI Muhammet Emin , PACCİ Sena
Published: April 2023

Bu çalışmanın amacı, çam ormanlarıyla kaplı alanların çölleşme risk değerlendirmesinde Akdeniz Avrupası için Çölleşme Gösterge Sistemi (DIS4ME) yaklaşımında ele alınan indikatörleri dikkate alarak, Ilgaz Dağı Milli Park sınırları içerisinde doğal çam orman arazilerinin çölleşme risk değerlendirmesini yapmaktır. Çölleşme risk değerlendirmesinde 8 indikatör (yağış, kuraklık, toprak bünyesi, taşlılık, bitki örtüsü-kapalılık, eğim, derinlik ve bakı) ele alınmıştır. Fakat, DIS4ME yaklaşımından farklı olarak bu çalışmada ele alınan indikatör indeks değerleri modelden birebir alınmayıp, Bulanık-Analitik Hiyerarşik Süreç (Bulanık-AHP) yaklaşımı ile daha da hassaslaştırılmıştır. Toprakların temel fiziko-kimyasal özellerini belirlemek amacıyla alandan 151 toprak örneği alınmıştır. Ilgaz Dağı Milli Park alanı içerisinde çölleşme risk değerlendirmesi yönünden alanda dağılım gösteren toprakların büyük bir çoğunluğunun çölleşme riski altında olduğu belirlenmiştir. Ayrıca, çalışmada elde edilen model sonuçları yapay sinir ağları ile tahmin edilmiştir. Elde edilen sonuçlara göre, çölleşme riskinin belirlenmesinde % 99 doğrulukla tahmin edilebilir olduğu belirlenmiştir.
Tüketicilerin Yöresel Ürünleri İnternet Üzerinden Satın Alma ve Pazarlama İstekliliğini Etkileyen Faktörler
Authors: GÜRÜN Seda , İKİKAT TÜMER Emine
Published: April 2023

Bu çalışmada tüketicilerin yöresel ürünleri online satın alma ve pazarlama isteklilikleri üzerinde etkili sosyo-demografik ve ekonomik faktörlerin belirlenmesi amaçlanmıştır. Bu amaç doğrultusunda, Kahramanmaraş ilinde 2019 Aralık-2020 Temmuz ayları arasında internet alışverişi yapan 384 katılımcı ile anket yapılmış olup, elde edilen veriler tanımlayıcı istatistikler ve Ki-kare testi ile analiz edilmiştir. Analiz sonucunda yöresel ürünleri online satın alma istekliliği üzerinde yaş, eğitim düzeyi, gelir düzeyi, gıda harcaması, e-ticaret deneyimi, kredi kartı kullanma durumu, alışveriş öncesi araştırma yapma durumu değişkenlerinin önemli olduğu saptanmıştır. Yöresel ürünlerin online pazarlamasını yapma istekliliği üzerinde ise cinsiyet, eş çalışma durumu, gelir düzeyi, aylık tasarruf miktarı, yöresel ürün satın alma durumu, fiyat kıyaslaması yapma durumu değişkenlerinin etkili olduğu tespit edilmiştir. Yöresel ürünlerin yerel ve genel ekonomiye katkısı, istihdam olanaklarını artırması, girişimcilik faaliyetlerine yeni bir fonksiyonellik katması, kültürel ve sürdürülebilir gıda tüketimi yönüyle gelecek nesillere miras bırakılması gibi önemli kazanımlara sahip olması nedeniyle internet üzerinden satın alımının ve pazarlamasının yapılmasının teşvik edilmesi gerekir.
Agronomic Characteristics and Yield Values of Sesame (Sesamum indicum L.) Cultivars at Various Sowing Dates
Authors: IZGI M. Necat , BULUT Burhan
Published: April 2023

In this study, ten different sesame (Sesamum indicum L.) cultivars registered in Türkiye were investigated for their sowing dates as a second crop in the lowlands of Mardin province, in 2018 and 2019. In this study, ten different sesame cultivars were used; these were Arslanbey, Boydak, Cumhuriyet-99, Hatipoğlu, Muganlı-57, Orhangazi-99, Osmanlı-99, Sarısu, Tan-99, and Tanas. Four different sowing dates (June 5, June 15, June 25, and July 4) were examined for these cultivars. In this study, agricultural parameters such as plant height, number of lateral branches, number of capsules, seed yield, oil ratio, and oil yield of the sesame cultivars were investigated. Different sowing dates were found to have a significant effect on the sesame cultivars. The second sowing date resulted in the highest plant height, number of branches, number of capsules, seed yield, oil content, and oil yield (June 15). In terms of cultivars, the Boydak and Sarısu had the highest seed yield (2184 and 2149 kg ha-1, respectively), the Osmanlı-99 (54.6%) had the highest oil ratio, and the Sarısu and Boydak had the highest oil yield (1075 and 1062 kg ha-1, respectively). The Boydak and Sarısu cultivars are promising for high seed and oil yields in the second crop sowing, and a sowing date of June 15 is advised.
Strategi Kelangsungan Pedagang Kecil di Pasar Tradisional
Authors: Hariyono Syech
Published: April 2023

The Small Scaled businesses at Blauran traditional market Surabaya perform their businesses commercially in impersonal and independent market system. In order to survive, those businesses depend hiqhly on the ability in attracting buyers/\. The trategy used to draw the buyers’ interests is by adding the capitals of the businesses throuqh merchandise credit system, in the sense that they continuously increase their merchandise on display by gaining them from the creditors. This study applied qualitative method to obtain descriptive data, while the research samples were taken by using Purposive Sampling technique, based on the merchandise they sell to the customers.

The data analysis described the social background of those small-scaled business operators before they decided to be small-scaled traders, their ages and education, their geograpchical mobility, and their binding to their native culture. In addition, it also discussed the business activities of those small-scaled merchants, related to their business chains, their capitals and their relationships with the buyers. In their trading chains, those merchants applied the strategy of increasing their business capital throught merchandise credit system, producer consigment, agent consigment, and supplier consigment. There are five patterns of credit they applied in order to increase their capitals. They are : (1) regular customer credit, (2) upon selling payment credits, (3) installment system, (4) consignment, and (5) comission system. The first pattern enables the merchants to obtain a relatively large amount of merchandise credits with a payment due after a certain period of time. The second pattern provides the merchants with merchandise in the morning and the payment due is at night. While the third pattern enables them to get merchandise with a regular partial payment at agreed time periodically. The fourth pattern means that they obtain merchandise from supplier and the payment can be done when the goods have been sold. And the fifth pattern enables the merchants to obtain merchandise with the basic price agreed by the merchants and the suppliers, then the merchants can resell it at a price profitable for them. The above five patterns are done by the merchants, not only to increase the volume of their merchandises but also to establish position in the distibution chains of the market.
Theoretical Explanation and Experimental Design of the Origin of Earth's Magnetic Field, Stellar Magnetic Field, and Neutron Star Magnetic Field
Authors: Qin Sheng
Published: April 2023

There is currently no unified explanation for the origin of Earth's magnetic field, planetary magnetic fields, stellar magnetic fields, and neutron star magnetic fields, and most importantly, none of these theories have been experimentally verified. This paper is based on a new unified theory of mechanics and its derived applications, which may provide a better explanation for the origin of magnetic fields in celestial bodies and can be experimentally tested to better answer the observed phenomena: (1) the greater the mass of the celestial body, the stronger the magnetic field; (2) the faster the rotation speed of the celestial body, the stronger the magnetic field; (3) the higher the density of the celestial body, the stronger the magnetic field produced.
Avaliação da educação superior no sistema estadual paulista: Articulações entre o CEE/SP e Unesp/São José do Rio Preto
Authors: Oliveira Maria Eliza Nogueira , Borges Regilson Maciel , Bernardes Joelma dos Santos
Published: April 2023

O artigo analisa os processos de avaliação realizados pela Universidade Estadual Paulista “Júlio de Mesquita Filho” (UNESP), campus São José do Rio Preto, e sua relação com as diretrizes formuladas no âmbito do Conselho Estadual de Educação de São Paulo (CEE/SP). Trata-se de uma pesquisa documental com base em deliberações e pareceres emitidos pelo CEE/SP, assim como nos Planos de Desenvolvimento Institucional (PDI) e nos Relatórios de Avaliação Institucional quinquenais produzidos pela UNESP/São José do Rio Preto. A análise considerou os ciclos da Avaliação Institucional da UNESP, iniciado no ano de 2000, sendo o último relatório divulgado em 2019. A coleta para a avaliação e a regulação reúne dados da avaliação da graduação, considerando o Enade; da avaliação da Pós-Graduação coordenada pela Capes; da avaliação institucional da pesquisa, a partir de todos os processos avaliativos e regulatórios desenvolvidos pela instituição; da avaliação institucional da extensão, conforme parâmetro da Política Nacional de Extensão Universitária (PNEU); e da gestão, cujos dados revelam que o processo se ancora na perspectiva do gerenciamento, visando a melhor alocação do orçamento, e dos recursos financeiro e humano na IES. Os resultados demostram que a UNESP segue as diretrizes presentes nas deliberações do CEE/SP, no que se refere aos processos de avaliação e regulação para as IES. A UNESP é dotada de um robusto sistema integrado e interligado com os diversos setores acadêmicos, cuja finalidade é coletar dados institucionais dos diferentes processos de avaliação que retroalimentam o sistema geral de regulação da Instituição.
Morse Fall Scale As Clinical Predictor Of 3-Month Neurologic Function Recovery On Ischemic Stroke Patients: A Prospective Cohort Study
Authors: Sakti Triono Agung , Hamidi Baarid Luqman , Prabaningtyas Hanindia Riani
Published: April 2023

Background: Stroke is a leading cause of death in developing countries. The Morse Fall Scale (MFS)'s use in predicting stroke clinical outcomes has not been extensively studied. This study aims to assess MFS's ability to predict neurological recovery in acute ischemic stroke patients within 3 months using the National Institutes of Health Stroke Scale (NIHSS).
Methods: This prospective cohort study enrolled all individuals with acute ischemic stroke between September and November 2021. Patients' baseline data included their MFS and NIHSS scores, as well as their age, gender, weight, stroke location, and comorbidities. The NIHSS score was reassessed three months later. To identify NIHSS predictors, all baseline data will be analyzed. SPSS 22 was used to analyze the data. The local ethics committee approved the study.
Results: Of the 164 patients who met the criteria, only 105 (mean age 59.09 [±11.65], male [58.1%], anterior location [88.6%]) reached the study end point. The average NIHSS score decreased from 9.14 (±1.70) to 6.27 (±1.92). Multiple linear regression showed only the MFS score (p = 0.000) accurately predicted the NIHSS by 0.059 (95% CI: 0.032–0.085, p = 0.000) at the study's conclusion.
Discussion: Our investigation revealed that the baseline MFS score accurately predicted neurological improvement in patients who had suffered an ischemic stroke over a three-month period. It is considered that the greater risk of falling results in a delay in the patient's rehabilitation. Investigation with larger sample sizes and longer monitoring intervals are required to corroborate our findings.
Education Research in Orthopaedic Surgery
Authors: Martinez Victor H. , Zaheer Aroob , McCarrell Jerod , Checketts Jake X. , Hanson Chad D.
Published: April 2023

Introduction:

With the ever-changing dynamics of surgical training, it is essential for the content of educational research to evolve simultaneously. This study aimed to assess the current state of scholarly work in orthopaedic training education and to identify particular educational topics that are trending in the literature.

Methods:

A PubMed search string was used to identify literature on orthopaedic surgery education from 2016 to 2021. Publications on orthopaedic surgery education were divided into 8 education-based categories: (1) operative training and simulation, (2) curriculum and career development, (3) diversity, (4) wellness and burnout, (5) program evaluation and match data, (6) trainee assessments, (7) social media, and (8) other. Univariate analysis and linear regression were used to determine trends.

Results:

A total of 383 orthopaedic surgery education publications met inclusion criteria. Orthopaedic surgery education publications accounted for 0.47% of the total publications from all 54 journals. Fifteen journals provided 85% of all orthopaedic education publications (N = 325). The Journal of Bone and Joint Surgery produced the most orthopaedic surgery education publications (76, 20%), followed by the Journal of Surgical Education (62, 16%) and the Journal of the American Academy of Orthopaedic Surgeons (58, 15%). Publications on curriculum and career development were the most common (21.9%). The following most frequent topics were program evaluation and match data (20.9%) and operative training and simulation (18%), respectively. Over the study period, the total amount of orthopaedic surgery education articles increased significantly (R2 = 0.86, p = 0.008). Articles included all levels of training, with resident education accounting for the majority, with 269 articles (70.2%).

Conclusion:

Recent trends in orthopaedic literature indicate an increased emphasis on education as the number of publications has increased, but are still sparse in orthopaedic literature. As the field of orthopaedics continues to advance, we recommend that academic institutions and organizations continue to evaluate and promote evidence-based educational research to ensure that orthopaedic education meets the ever-increasing demands that residents and practicing surgeons will face in the present and future.

Level of Evidence:

III
Augmented Reality Surgical Navigation in Minimally Invasive Spine Surgery: A Preclinical Study
Authors: Huang Xin , Liu Xiaoguang , Zhu Bin , Hou Xiangyu , Hai Bao , Li Shuiqing , Yu Dongfang , Zheng Wenhao , Li Ranyang , Pan Junjun , Yao Youjie , Dai Zailin , Zeng Haijun
Published: April 2023

Background: Augmented reality (AR) is a technology that combines virtual information with the real-world environment. In the medical field, AR technology can be used to show information inside the body.
Methods: We combined augmented reality, artificial intelligence and optical tracking to enhance the augmented reality minimally invasive spine surgery (AR-MISS) system. The system has three functions: augmented reality radiograph superimposition, AR real-time puncture needle tracking and AR intraoperative navigation. The three functions of the system were preliminarily evaluated through beagle animal experiments.
Results: The AR radiographs were successfully superimposed on the real intraoperative videos. The anteroposterior and lateral errors of superimposed AR radiographs were 0.74 ± 0.21 mm and 1.13 ± 0.40 mm, respectively. The puncture needles could be tracked by the AR-MISS system in real time. The anteroposterior and lateral errors of the real-time AR needle tracking were 1.26 ±0.20 mm and 1.22 ± 0.25 mm, respectively. With the help of AR radiographsand AR puncture needles, the puncture procedure could be guided visually by the system in real time. The anteroposterior and lateral errors of AR-guided puncture were 2.47 ±0.86 mm and 2.85± 1.17 mm, respectively.
Conclusion: Theresults indicate that the AR-MISS system is accurate and feasible in a beagle model. Additional clinical assessment is needed.
Huazhuojiedu Decoction Regulates Mitophagy to Alleviate Precancerous Lesions of Gastric Cancer via Sirt3/Foxo3a/Parkin Pathway
Authors: Yang Tianxiao , zhou pingping , Zhang ziwei , hao xinyu , liu shaowei , chen haoyu , Wang yuhua , wang yangang
Published: April 2023

Backgroud：Huazhuojiedu decoction (HZJD) has been demonstrated to be effective in the treatment of precancerous lesions of gastric cancer (PLGC). We aimed to explore the potential mechanisms of HZJD for alleviating PLGC in vivo and in vitro.
Methods: The PLGC rat model was established by administrating 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG) and sodium for 24 weeks, followed by 10 weeks of HZJD decoction or vitamin B12 therapy. The PLGC cell model (MC) was prepared by inducing human gastric mucosal epithelial cells (GES-1) with MNNG. HZJD decoction and vitamin B12 drug-containing serum were given to treat MC cells, meanwhile sirt3 siRNA was transfected into MC cells. The CCK-8 assay and the EdU assay were used to detect cell proliferation. The histopathological changes of gastric tissues were observed by H&E staining, HID/AB staining and AB/PAS staining. The mRNA and protein expressions of on mitophagy-related molecules were detected by RT-qPCR and Western blot. Immunohistochemistry was used to test the differential expressions of sirt3/foxo3a/parkin pathway. Immunofluorescence was used to evaluate mitophagic level. Transmission electron microscopy was used to monitor the degree of mitochondrial damage and the occurrence of mitophagy.
Results: The results indicated that HZJD could retard the pathological progress of gastric mucosa in PLGC rats and reduce the elevated cell proliferation in MC cells. The treatment of HZJD could significantly increase the gene and protein expressions of sirt3, foxo3a, parkin, LC3Ⅱ/Ⅰ, meanwhile decrease the mRNA and protein expressions of p62, tomm20. The colocalization of LC3 and COX Ⅳ was inhibited in PLGC rats, besides the fluorescent intensity of mitophagy was weakened in MC cells. This downtrend of mitophagic level in vivo and in vitro could be reversed by HZJD. More importantly, the improvement of mitophagy by HZJD was associated with sirt3/foxo3a/parkin pathway.
Conclusions: Our results suggested that HZJD decoction could ameliorate PLGC in vivo and in vitro, and its therapeutic effect might be related to regulating mitophagy via sirt3/foxo3a/parkin pathway.
Willingness to receive COVID-19 vaccine and associated factors among students of higher education institutions: the case of Rift Valley University, Adama, Central Ethiopia: a cross sectional study
Authors: Mandefro Endashaw
Published: April 2023

Introduction: The accelerated global spread of COVID-19 and its high death rate have prompted the World Health Organization to implement vaccination as an effective way to curb the spread of the disease. Accordingly, Ethiopia has launched a national vaccination campaign against the disease. However, the willingness of people to receive the vaccine was considered as an important pre-requisite for the success of the vaccination campaign. The aim of this study was to assess the magnitude of willingness towards COVID-19 vaccination and associated factors among students at Rift Valley University, Adama, Ethiopia, in 2022.
Methods: A cross-sectional study was conducted from January 10 to January 25, 2022 among 490 randomly selected students at Rift Valley University, Adama campus. Data was collected by using an interviewer administered questionnaire and was entered into Epi Info version 7 and exported to SPSS version 21 for cleaning and analysis.
Results: The proportion of willingness to receive the COVID-19 vaccine was 60.2% (95%CI: 55.9, 64.5). Being male (AOR: 2.72; 95% CI: 1.14, 2.76), having a family history of COVID-19 infection (AOR: 1.2, 95% CI: 1.07, 1.54), having ever taken any vaccine (AOR: 1.7, 95% CI: 1.14, 2.27), and respondents believing the COVID-19 vaccine has no severe side effects (AOR: 2.3, 95% CI: 1.27, 3.01) were all positive predictors of willingness.
Conclusions: The proportion of willingness to get the COVID-19 vaccine among students of higher education institution in Adama town was far lower than that of the nationwide expected result. Male sex, having a family history of COVID-19 infection, having ever taken any vaccine, and the thought of respondents that the COVID-19 vaccine has no severe side effects were independent predictors of willingness to receive the vaccine.
Recalibration of Framingham Risk for a local population of Sri Lanka
Authors: Ranasinghe Sameera Upashantha , Ekanayake E M D S , Ranasinghe Laksitha Iroshan , Tennakoon Sampath U.B
Published: April 2023

Background
Cardiovascular Diseases (CVD) account for highest number of deaths and disability globally and within Sri Lanka. A CVD risk prediction tool is a simple mean of early identification of high-risk groups which is a cost-effective preventive strategy especially for resource poor countries. Distribution of risk factor levels vary in different regions even within the same country, thus a common risk estimation tool for the country may give false local predictions. Since there’s few published data related to Sri Lanka the aim of this study was to recalibrate the Framingham equation according to the local risk factor profile of a population in Kurunegala region in Sri Lanka.
Method
A cross sectional study was conducted with the participation of 1 102 persons from Kurunegala Regional Director of Health Services area and the data was collectedusing an interviewer administered questionnaire, anthropometric, blood pressure and biochemical measurements.
Results
Original and recalibrated Framingham CVD risk scores predicted 55.5% (N = 612) and 62.3% (N=687) to be having less than 10% CVD risk respectively. Further, the original and recalibrated CVD Risk Scores predicted 2.2% (N = 24) and 1.8% (N=20) to be having CVD risk more than 40% respectively.
Conclusion
These findings show an over prediction of the CVD risk with the original Framingham risk calculations which signifies the importance of development of a region-specific risk prediction tool using local risk factor data in Sri Lanka whichwill prevent unnecessary expenditure to manage people without risk of CVD.
The effect of ultrasound-guided lung recruitment maneuvers on perioperative atelectasis for adults undergoing general anesthesia:A meta-analysis
Authors: Li Shuji , Zhang Shuang , Yin Hong , Yi Mingliang
Published: April 2023

Background:
To systematically evaluate the effects of ultrasound-guided lung recruitment maneuvers(U-LRM) on he incidence of perioperative atelectasis and the Lung ultrasound scores(LUS) with adults undergoing general anesthesia.
Materials and methods
we searched relevant studies in CNKI,Wanfang,CBM,PubMed, EMBASE, and the Cochrane Library up to December ,2022. Based on the inclusion and exclusion criteria, the literatures were strictly screened, and meanwhile the Revman 5.4 software was used to evaluate the migration risk of the included research included research and complete data analysis.
Results
7 RCT studies were included with a total of 396 adult patients.Among the stuey compared U-LRM with Non-LRM,RCTs showed a significant benefit of U-LRM for reducing the incidence of atelectasis at T3(RR = 0.52;95%CI [0.39, 0.69];P < 0.001;I² = 0%) and the LUS at T3(MD=-3.50; 95%CI[-5.06, -1.94];P < 0.001;I² = 86%).Among the stuey compared U-LRM with LRM, RCTs showed a significant benefit of U-LRM for reducing the incidence of atelectasis at T2(RR = 0.49;95%CI[0.36, 0.68];P < 0.001 I = 0%) and the LUS at T2(MD=-1.50; 95%CI[-2.90, -0.09];P = 0.04;I = 87%)and T3(MD=-1.58;95%CI [-2.68, -0.47];P = 0.005;I = 78%)
Conclusion
According to the study,ultrasound-guided lung recruitment maneuvers(U-LRM) may have an association with decreasing in the incidence of perioperative atelectasis and lung ultrasound scores. However,the result must be explained cautiously as the total patients is insufficient.
Spinal Echinococcus multilocularis infection mimicking tuberculosis: a rare case of vertebral alveolar echinococcosis in China
Authors: Li Chun , Luo Lei , Jin Da-di , Li Chuan-jiang , Yang Bin , Yang Ju-hua
Published: April 2023

Echinococcus multilocularis (E. multilocularis) infection can cause alveolar echinococcosis (AE), a zoonosis that rarely affects humans. Although the incidence of AE has increased substantially, its diagnosis remains challenging due to a lack of clinical manifestations and imaging findings specific to this disease. Here, we described a case of vertebral AE in an elderly male from south China, who was initially misdiagnosed as tuberculosis. After being diagnosed of E. multilocularis complicated with Serratia marcesceninfections by metagenomic next-generation sequencing, the patient received anti-infective treatment, and his condition improved and was finally discharged. Hence, clinicians should increase their awareness of AE as a cause for vertebral lesions, except malignancy and tuberculosis.
Exploring the role of healthcare personnel in designing Tuberculosis Infection Prevention and Control measures in healthcare settings: A scoping review
Authors: Masuku Sikhethiwe , Mooa Ramadimentja Shirley , Peu Mamphekho Dorrica , Ndwandwe Duduzile , Moloto Tebogo Brenda Sole , Walt Martie van der
Published: April 2023

Background
Healthcare personnel (HCP) in high TB burdened countries continue to be at high risk of occupational TB due to inadequate implementation of Tuberculosis Infection Prevention and Control (TB-IPC) measures, lack of understanding of the context and relevance to local settings. Such transmission in the healthcare workplace has prompted the development and dissemination of numerous guidelines for strengthening TB-IPC for use in settings globally. However, a growing body of literature points to lack of involvement of the HCP in the conceptualization and development of guidelines and programmes seeking to improve TB-IPC in high burden countries generally.
Objectives
The aim of this study is to identify factors affecting and influencing the adoption of TB-IPC measures in heath settings and the recognised research field exploring the inclusion of the HCP in decision making when designing these guidelines, in relation to appropriateness of the guidelines to the local context.
Methods
A scoping review methodology was selected for this study to gain insight into the relevant research evidence identifying and mapping key elements in the TB-IPC measures in relation to HCP as implementors.
Results
Studies in this review refer to factors related to HCP’s knowledge of TB-IPC, perception regarding occupational risks, behaviours, and their role against a background of structural resource constraints, and guidelines adherence. They report several challenges in the TB-IPC implementation and adherence particularly eliciting recommendations from HCP for improved TB-IPC practices.
Conclusion
Research on the enablers and barriers to TB-IPC implementation needs to go beyond mere documenting factors affecting and influencing adoption of TB-IPC measures in heath settings. There is an urgent need for research on participation of the implementers in the decision making when developing TB-IPC guidelines. Finally, when designing the TB-IPC guidelines, factors to be considered should be the appropriateness of the guidelines to the local context.
Construction and validation of prognostic risk model based on radiosensitivity-related immune genes in rectal cancer
Authors: Yang Hui , Liu Yin , Mu Xiaofeng , Wang Kun , Hao Mengdi , Li Huimin , Liang Xiaoqing , Yuan Dajin , Ding Lei
Published: April 2023

Background
Radiotherapy is closely related to the tumor immune microenvironment, but the role of immune genes in radiosensitivity and prognosis of rectal cancer (RC) is still unclear. This study aims to construct a prognostic risk model based on radiosensitivity-related immune genes (RRIGs), which can be used for predicting prognosis of RC.
Methods
GSE133057 dataset of RC was downloaded from the Gene Expression Omnibus (GEO) database, and differentially expressed genes (DEGs) were identified between different radiosensitivity groups. RRIGs were obtained by intersecting DEGs and immune genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways analysis were performed to study the biological functions of RRIGs. Transcriptomic and clinical data of RC were downloaded from The Cancer Genome Atlas (TCGA) database, and the entire cohort was randomly divided into training and testing set at a ratio of 7:3. Prognostic genes were selected by Cox analysis, and a risk model and nomogram were subsequently built. The relationship between the model and immune cell infiltration was analyzed by single-sample gene set enrichment analysis (ssGSEA).
Results
A total of 76 RRIGs were identified, and they were mainly involved in immune-related biological processes and pathways. BMP2, COLEC10, MASP2, and GCGR were screened as prognostic genes after Cox regression analysis. Subsequently, these prognostic genes were used to construct a risk score model, which demonstrated good performance in predicting prognosis, as proven by the receiver operating characteristic (ROC) curves. Cox regression analysis showed that the risk score was an independent prognostic factor for RC. Moreover, we found that the immune microenvironment was different between the low- and high-risk groups.
Conclusions
We developed and validated a prognostic risk model based on RRIGs, which could serve as a tool for predicting prognosis of RC. These findings enhanced the understanding of the relationship among radiosensitivity, immune genes and prognosis in RC.
Integrated muti-omics analyses and experimental validation reveal the clinical and biological Significances of APBB1IP in Colon Cancer
Authors: Ni Zhizhan , Chen Xin , Huang Qi , Zhou Jinzhe , Xie Huahao , Wang Song , Jiang Jiebang , Liu Liming , Ge Bujun
Published: April 2023

Background： Tumor-associated macrophages(TAMs), especially M2 macrophages, plays a critical role in Colorectal cancer initiation, promotion, and metastasis. However, the underlying mechanisms still remain unresolved.
Methods：The profile of ATAC-seq was employed to detect genes with open chromatin. The RNA-seq was used to identify differentially expressed genes (DEGs) and those DEGs with open chromatin in promoter regions were identified as hub gene. Then, CIBERSORT, quanTIseq and XCELL algorithm were employed to quantified the expression of M2 macrophages and Pearson correlation analysis was used to identified the relationship with M2 macrophages and hub gene. After that, the macrophages profile and scRNA-seq profile were used to identify the gene expression in different phenotype macrophage. GO/KEGG analysis, GSEA, GSVA were used for gene function analysis. Finally, the target gene which promote M2 macrophages polarization were further explored by experiment.
Results：In this study, we acquired 15,650 genes with open chromatin in promoter regions and 3,241 genes were identified as differential expression genes with open chromatin. Integrated CIBERSORT, quanTIseq and XCELL algorithm, we identified 72 genes were correlated with M2 macrophages (r>0.2, p<0.05). According to the macrophages profile from GEO database, 2 genes were identified as differential expressed genes which high expressed in M2 macrophages. By applying scRNA-seq, APBB1IP was the only gene expressed in macrophage and high expressed in M2 phenotype. M2 macrophage polarization were inhibited after knockdown of APBB1IP in vitro experiments.
Conclusion：APBB1IP, characterized by chromatin accessibility, downregulated in patients with COAD and induced M2 macrophage polarization.
The effectiveness of World Café-based flipped classroom to optimal interprofessional education among interprofessional healthcare workers: A quasi-experimental study
Authors: Li Hong-Ying , Hsu Tzu-Chuan , Huang Chu-Yu , Kuo Chien-Lin , Cheng Su-Fen
Published: April 2023

Background
Quality of healthcare outcomes rely heavily on effective interprofessional collaboration. However, inadequate communication and team collaboration may contribute to ineffective interprofessional collaborative practice (IPCP) and negatively impact patient safety. Traditionally, IPCP training sessions are conducted primarily through lectures with limited interactions across disciplines, which may create obstacles in cultivating effective interprofessional communication. Teaching strategies that combine the World Café approach with flipped classroom (WCFC) approach may improve team communication and collaboration. The purpose of this study was to evaluate the effectiveness of World Café-based flipped classroom (WCFC) approach in promoting interprofessional collaborative practice behaviors, learning engagement and learning satisfaction.
Methods
This quasi-experimental study used two-group repeated measure longitudinal design with a convenience sample. Seventy-six healthcare professionals participated in this study. The experimental group (n=38) completed a case studydiscussion course through the WCFC approach, whereas the control group (n=38) received the same course through a traditional teaching approach. Data collection took place before the intervention, one week and four weeks after the intervention. The instruments utilized were demographic information sheet, Lee’s (2016) Interprofessional Collaborative Practice Behavior Inventory (IPCPBI), Ciou’s (2020) Learning Engagement Scale, and Huang’s (2013) Learning Satisfaction Scale.
Results
There were no significant differences in the IPCPBI scores between the experimental and control groups one week after the intervention (p >.05). Analyses of the delay effects four weeks after the intervention foundsignificantly higher IPCPBI scores in the experimental group than the control group (p < .05). The learning engagement scores and learning satisfaction scores were higher in the experimental group but did not reach statistical significance (p> .05).
Conclusions
Case studydiscussions conducted using the WCFC approach effectively improved IPCPbehaviors, learning engagement and learning satisfaction in healthcare professionals. The World Café approach created a relaxing atmosphere for learning, and encouraged sharing among participants. Each participant experienced freedom and equal opportunities to contribute in interprofessional collaborative practice for the optimized care outcomes.
Surgical treatment of abdominal stab wounds: A retrospective evaluation of 100 cases in a low- incidence environment
Authors: Lerchenberger Maximilian , Krendl Felix J. , Karcz Konrad , Schirren Malte , Zhang Yunjie , Hallfeldt Klaus , Ladurner Roland
Published: April 2023

Purpose
Abdominal stab wounds (ASW) represent a rare subclass of trauma in Europe and might therefore cause uncertainty in choosing the adequate therapeutic approach. Therefore, the aims of this retrospective study were (1) to investigate patient outcome with regard to the treatment method and (2) to develop a diagnostic and therapeutic algorithm for laparoscopic surgery.
Methods
100 cases of (thoraco-) abdominal stab wounds (T/ASW)were identified from 2003 to 2019. A review of the medical records identified injury patterns, Injury Severity Score, diagnostic approaches, therapy, morbidity and mortality, length of treatment, and patient outcomes.
Results
T/ASW occurred in 53 cases due to violent crime, in 11 cases due to accidents and in 36 cases with suicidal intent. Gender distribution was 82 male, 18 female, and the average age was 41 years. The majority (n = 65) of these patients were admitted to our center via the trauma unit. 33 patients received local wound exploration and were admitted to the hospital for observation. Two of these patients deteriorated during the observation period and were admitted to the OR. Laparoscopy was performed in 27 cases, with 6 conversions to laparotomy. 39 patients underwent primary laparotomy. Overall, complications requiring further intervention occurred in six cases. Four patients died; three patients died postoperatively, and one patient died in the trauma bay. The length of hospital stay was significantly shorter int patients undergoing laparoscopic treatment than in patients receiving laparotomy.
Conclusion
The decision for surgical exploration of ASW should be made generously. Primary laparoscopic exploration is recommended in stable patients. For critically injured patients, laparotomy remains the gold standard.
PLOD2, a key factor for MRL MSC metabolism and chondroprotective properties
Authors: Bahraoui Sarah , Tejedor Gautier , Mausset-Bonnefont Anne-Laure , Autelitano François , Jorgensen Christian , Wei Mingxing , Djouad Farida
Published: April 2023

Background: Initially discovered for its ability to regenerate ear holes, the MRL mouse has been the subject of multiple research studies aimed at evaluating its ability to regenerate other body tissues and at deciphering the mechanisms underlying it. These enhanced abilities to regenerate, retained in the adult, protect the MRL mouse from degenerative diseases such as osteoarthritis (OA). Here, we hypothesized that MSC derived from the regenerative MRL mouse could be involved in their regenerative potential through the release of pro-regenerative mediators.
Method: To address this hypothesis, we compared the transcriptome of MRL and BL6 MSC and identified several candidate molecules expressed at significantly higher levels by MRL MSC than by BL6 MSC. We selected one candidate and performed functional in vitro assays to evaluate its role on MRL MSC properties including metabolic profile, migration, and chondroprotective effects. Using an experimental model for osteoarthritis (OA) induced by collagenase (CiOA), we assessed its contribution to MRL MSC protection from OA.
Results: Among the candidate molecules highly expressed by MRL MSC, we focused our attention on procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (PLOD2), coding for the lysyl hydrolase LH2 in charge of post-translational modifications of collagen for its stability and stiffness. PLOD2 is induced by hypoxia-inducible factor 1-alpha (HIF-1a) involved in the regeneration process of adult MRL mice. Plod2 silencing induced a decrease in the glycolytic function of MRL MSC, resulting in the alteration of their migratory and chondroprotective abilities in vitro. In vivo, we showed that plod2 silencing in MRL MSC significantly impaired their capacity to protect mouse from developing OA.
Conclusion: Our results demonstrate that the chondroprotective and therapeutic properties of MRL MSC in the CiOA experimental model are in part mediated by PLOD2.