bluuebunny/crossref_metadata_2025 huggingface dataset:
Integrated Physiologic Assessment of Ischemic Heart Disease in Real-World Practice Using Index of Microcirculatory Resistance and Fractional Flow Reserve
Authors: Lee Joo Myung , Layland Jamie , Jung Ji-Hyun , Lee Hyun-Jung , Echavarria-Pinto Mauro , Watkins Stuart , Yong Andy S. , Doh Joon-Hyung , Nam Chang-Wook , Shin Eun-Seok , Koo Bon-Kwon , Ng Martin K. , Escaned Javier , Fearon William F. , Oldroyd Keith G.
Published: October 2015

Background—

The index of microcirculatory resistance (IMR) is a quantitative and specific index for coronary microcirculation. However, the distribution and determinants of IMR have not been fully investigated in patients with ischemic heart disease (IHD).

Methods and Results—

Consecutive patients who underwent elective measurement of both fractional flow reserve (FFR) and IMR were enrolled from 8 centers in 5 countries. Patients with acute myocardial infarction were excluded. To adjust for the influence of collateral flow, IMR values were corrected with Yong’s formula (IMR
corr
). High IMR was defined as greater than the 75th percentile in each of the major coronary arteries. FFR≤0.80 was defined as an ischemic value. 1096 patients with 1452 coronary arteries were analyzed (mean age 61.1, male 71.2%). Mean FFR was 0.84 and median IMR
corr
was 16.6 U (Q1, Q3 12.4 U, 23.0 U). There was no correlation between IMR
corr
and FFR values (
r
=0.01,
P
=0.62), and the categorical agreement of FFR and IMR
corr
was low (kappa value=−0.04,
P
=0.10). There was no correlation between IMR
corr
and angiographic % diameter stenosis (
r
=−0.03,
P
=0.25). Determinants of high IMR were previous myocardial infarction (odds ratio [OR] 2.16, 95% confidence interval [CI] 1.24–3.74,
P
=0.01), right coronary artery (OR 2.09, 95% CI 1.54–2.84,
P
<0.01), female (OR 1.67, 95% CI 1.18–2.38,
P
<0.01), and obesity (OR 1.80, 95% CI 1.31–2.49,
P
<0.01). Determinants of FFR ≤0.80 were left anterior descending coronary artery (OR 4.31, 95% CI 2.92–6.36,
P
<0.01), angiographic diameter stenosis ≥50% (OR 5.16, 95% CI 3.66–7.28,
P
<0.01), male (OR 2.15, 95% CI 1.38–3.35,
P
<0.01), and age (per 10 years, OR 1.21, 95% CI 1.01–1.46,
P
=0.04).

Conclusions—

IMR showed no correlation with FFR and angiographic lesion severity, and the predictors of high IMR value were different from those for ischemic FFR value. Therefore, integration of IMR into FFR measurement may provide additional insights regarding the relative contribution of macro- and microvascular disease in patients with ischemic heart disease.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT02186093.
Polarimetric Tornadic Debris Signature Variability and Debris Fallout Signatures
Authors: Van Den Broeke Matthew S.
Published: October 2015

Values of polarimetric radar variables may vary substantially between and through tornadic debris signature (TDS) events. Tornadoes with higher intensity ratings are associated with higher average and extreme values of reflectivity factor at horizontal polarization ZHH and lower values of copolar cross-correlation coefficient ρhv. Although values of these variables often fluctuate through reported tornado life cycles, ZHH repeatably decreases and ρhv repeatably increases across the volume scan immediately following reported tornado demise. Land cover has a relatively small effect on values of the polarimetric variables within TDSs, although near-radar urban TDSs may exhibit relatively high ZHH values. TDS areal extent is typically larger aloft than near the surface, although this trend may reverse in the most intense tornadoes. Maximum altitude to which a TDS is visible is more strongly a function of tornado intensity than of land cover or ambient shear and instability. Debris often disappears once lofted but may also be observed to spread out downstream with the storm-relative flow or to fall out along the parent storm’s northwest flank in a debris fallout signature (DFS). DFS characteristics, although variable, most commonly include ZHH values of 30–35 dBZ, ρhv values of 0.60–0.80, and values of differential reflectivity ZDR that are repeatably near 0 dB.
Surface Solar Radiation in North America: A Comparison of Observations, Reanalyses, Satellite, and Derived Products*
Authors: Slater Andrew G.
Published: October 2015

Observations of daily surface solar or shortwave radiation data from over 4000 stations have been gathered, covering much of the continental United States as well as portions of Alberta and British Columbia, Canada. The quantity of data increases almost linearly from 1998, when only several hundred stations had data. A quality-control procedure utilizing threshold values along with computing the clear-sky radiation envelope for individual stations was implemented to both screen bad data and rescue informative data. Over two-thirds of the observations are seen as acceptable. There are 15 different surface solar radiation products assessed relative to observations, including reanalyses [Twentieth-Century Reanalysis (20CR), CFS Reanalysis and Reforecast (CFSRR), ERA-Interim, Japanese 55-year Reanalysis Project (JRA-55), MERRA, NARR, and NCEP–NCAR Reanalysis 1 (NCEP-1)], derived products [observations from the CRU and NCEP-1 (CRU–NCEP); Daily Surface Weather and Climatological Summaries (Daymet); Global Land Data Assimilation System, version 1 (GLDAS-1); Global Soil Wetness Project Phase 3 (GSWP3); Multiscale Synthesis and Terrestrial Model Intercomparison Project (MsTMIP); and phase 2 of the North American Land Data Assimilation System (NLDAS-2)], and two satellite products (CERES and GOES). All except the CERES product have daily or finer temporal resolution. The RMSE of spatial biases is greater than 18 W m−2 for 13 of the 15 products over the summer season (June–August). None of the daily resolution products fulfill all three desirable criteria of low (<5%) annual or seasonal bias, high correlation with observed cloudiness, and correct distribution of clear-sky radiation. Some products display vestiges of underlying algorithm issues [e.g., from the Mountain Microclimate Simulation Model, version 4.3 (MTCLIM 4.3)] or bias-correction methods. A new bias-correction method is introduced that preserves clear-sky radiation values and better replicates cloudiness statistics. The current quantity of data over the continental United States suggests that a solar radiation product based on, or enhanced with, observations is feasible.
Inductance of transmission lines: Deriving the flux linkage method from the generalized telegrapher’s equations
Authors: Scher Aaron D
Published: October 2015

This paper presents a clear derivation of the flux linkage method for calculating inductance of transmission lines with spatially disturbed (non-filamentary) current. The flux linkage method is a common tool for teaching and calculating inductance of distributed circuits, yet rarely derived from first principles in textbooks. This may confuse students into thinking the method is obvious. This paper proves the flux linkage method by generalizing the ordinary telegrapher’s equations to the case of transmission lines with spatially distributed current. Furthermore, we demonstrate the advantages of a systematic approach for calculating inductance by comparing it with the traditional approach for a coaxial cable.
Improving reading in Australia’s Outback
Authors: Sharratt Lyn , Hayes Peter , Coutts James
Published: October 2015

Ten years ago, six teachers established a program of literacy intervention and professional learning in remote northwestern Australia based on the Reading Recovery principles. This group of teachers was determined to learn what had to happen in order for them to make a difference with students and then to make it happen. Their work led to getting all the necessary players around the partnership table at the same time: all education sectors — local, regional, and national — noneducation government entities, business, parents, and other community partners.
Backtalk
Authors: Shirley Dennis
Published: October 2015

When the United States considers what it can learn from countries that perform well on the Program for International Student Assessment (PISA), it should consider the diversity the country’s population. Although much attention has been given to Finland, Japan, South Korea, and Shanghai, the United States would be smarter to look at Germany, a country with growing diversity and one that has shown consistent growth on PISA. Germany has improved while avoiding many of the market-based reforms that have gained traction in the U.S.
The Occupation of the Parque Indoamericano in Buenos Aires: Discourse Dynamics and Stakeholder Practices
Authors: Hölzl Corinna
Published: October 2015

In 2010, some 13,000 people occupied the second-largest park in Buenos Aires, located in the most deprived area of the city. The city and state governments reacted with violent repression leading to three deaths. After government officials promised that a housing program would be provided, the problem was viewed as “solved.” However, four years later not a single home had been built. Interpretive frames and political practices in Buenos Aires were influenced by the conflict, and this ultimately strengthened the positions of the national and local governments. This, in turn, intensified structural discrimination against lower-income groups in Buenos Aires. Thus, far from bringing about sustainable housing solutions, the occupation reinforced policies of security and sanction.

En 2010, cerca de 13,000 personas ocuparon el segundo parque más grande de Buenos Aires, ubicado en la zona más pobre de la ciudad. Los gobiernos de la ciudad y del estado reaccionaron con una violenta represión que causó tres muertes. Después de que los funcionarios gubernamentales prometieron establecer un programa de vivienda, el problema se dio por “solucionado.” Sin embargo, cuatro años más tarde no se había construido ni una sola casa. Los marcos interpretativos y las prácticas políticas en Buenos Aires se vieron influenciados por el conflicto, y esto terminó por reforzar las posiciones de los gobiernos nacionales y locales. Esto, a su vez, intensificó la discriminación estructural contra los grupos de más bajos ingresos en Buenos Aires. Por consiguiente, lejos de traer soluciones de vivienda sostenibles, la ocupación reforzó las políticas de seguridad y sanción.
Between area and discipline
Authors: Jazeel Tariq
Published: October 2015

This paper explores tensions that emerge from the injunction to make progress in geographical knowledge production in the globalizing landscape of higher education and research. The paper identifies gaps that emerge between disciplinary geographical knowledge production and area studies knowledge production, particularly connections to non-western areas on which many geographers work. It suggests these gaps are symptomatic and productive of the discipline’s problematically constituted community: the ‘we’ of Geography’s vanguard. The paper charts the precipitation of these tensions within Geography’s disciplinary dispositif before suggesting three alternative knowledge production tactics aimed at closing any such gaps and that in turn democratically reconstitute disciplinary Geography’s ‘we’.
Association of ADAM33 gene polymorphism and arginase activity with susceptibility to ventilatory impairment in wood dust-exposed workers
Authors: Saad-Hussein A , Thabet EH , Taha MM , Shahy EM , Mahdy-Abdallah H
Published: October 2015

ADAM33 represents an important gene of susceptibility for lung function impairment. This work aimed to evaluate the association between genetic polymorphism of ADAM33 at four single nucleotide polymorphisms (T1, T2, S1, and Q1) and arginase activity with respiratory functions impairment in wood workers. The study was done to compare ventilatory functions and arginase activity of 82 wood workers and 81 controls. Genotyping was determined by using the polymerase chain restriction fragment length polymorphism method. Forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), and peak expiratory flow rate (PEF) of the workers were significantly reduced compared with the controls. T1 single nucleotide polymorphism (SNP) was associated with obvious decline in the FEV1, FVC, and PEF in wood workers, while T2 SNP was associated with decline in FEV1 and PEF. A significant increase in arginase activity was found in T2 and S1 SNPs of the exposed workers. Increase in duration of exposure was correlated with the decline in ventilatory functions. This inverse correlation was significant for pulmonary function indices in AA and GG genotypes of T1 and T2, respectively. Moreover, significance was detected for FVC and FEV1 in AA and GA genotypes of S1 and Q1. A positive correlation between arginase activity and duration of exposure was found to be significant in GG genotype of S1 SNP. An association between ADAM33 gene polymorphism and impaired lung functions was detected in wood dust-exposed workers. Arginase activity may play an associated important role in increasing this impairment in wood workers.
Accounting history and religion: A review of studies and a research agenda
Authors: Cordery Carolyn
Published: October 2015

Since around 2003, the number and extent of studies into accounting history and religion has increased significantly from their prior scarcity. This growing interest in the junction of accounting, religion and theology recognizes the social and economic importance of belief systems and religious institutions. Yet, publications are unevenly distributed, with a focus on a micro-perspective – analysing the manner in which accounting is practised within organizations. Few studies take a macro-perspective to consider how religion influenced (or potentially could influence) accounting outside of religious institutions. The purpose of this article is to review the contributions in the last three decades, to highlight the topics that remain relatively unexplored, and thus to encourage more research into accounting history and religion. Opportunities for extending knowledge include: comparative studies, studies of countries, people and faiths that have been left largely unexplored, and studies from theologians concerning key concepts (such as ethics) which impact academic understandings, as well as the practical application, of accounting.
The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients
Authors: Siritho Sasitorn , Sato Douglas K , Kaneko Kimihiko , Fujihara Kazuo , Prayoonwiwat Naraporn
Published: October 2015

Background:

Myelin oligodendrocyte glycoprotein (anti-MOG) antibody was reported in anti-aquaporin-4 (anti-AQP4) seronegative neuromyelitis optica spectrum disorders (NMOSD) patients.

Objectives:

To describe clinical phenotypes associated with anti-MOG.

Methods:

Seventy consecutive Thai patients with inflammatory idiopathic demyelinating central nervous system disorders (IIDCD) who were previously anti-AQP4 seronegative were tested for anti-MOG.

Results:

Anti-MOG was positive in six patients, representing 20.7% of the IIDCD anti-AQP4 seronegative patients with a non-multiple sclerosis phenotype, and most had relapses. All first presented with optic neuritis with good visual recovery after treatment.

Conclusions:

Anti-MOG positive patients may have manifestations that mimic NMOSD but differ in their course and prognosis from anti-AQP4 positive NMOSD.
Interpreters – experts in careful listening and efficient encoding? Findings of a prose recall test
Authors: Hiltunen Sinikka , Vik Gun-Viol
Published: October 2015

Research Questions:

The purpose of the present experiment was to study interpreters’ recall of spoken prose.

Design:

The prose recall of simultaneous and consecutive interpreters was compared to that of foreign language teachers and non-linguistic experts. The professional experience of participants (21–24 participants in each group) was 10 years as a aminimum. The auditory presentation of the prose passage to be recalled, divided into eleven speech sequences, resembled the working conditions of interpreters.

Data:

Transcripted prose recall recordings were analysed quantitatively through an idea unit measure and qualitatively through meaning-based expressions.

Findings:

The foreign language expert groups outperformed the non-linguistic experts in both quantitative and qualitative measures. Additionally, compared to foreign language teachers, interpreters indicated a better recall of time expressions and topic sentences, as well as of complicated emotional and causal expressions. The explanation for these findings could indicate expertise-dependent tendencies: possibly a continuous practising of careful listening and the demand for a quick comprehension of the source text under the extreme time pressure of interpreters’ work leads to better results in prose recall. However, the findings can only be generalized to a limited extent because the prose passage used contained only one or two expressions of each type studied in the qualitative analysis.

Originality:

The study differs from previous studies in that the memory of interpreters, and especially of consecutive interpreters, was studied for the first time with a prose recall measure.

Significance:

The prose recall test revealed that the abilities of careful listening and effective comprehension of coherence and causality seem to play a significant role in explaining memory functions of simultaneous and consecutive interpreters compared to those of foreign language teachers and non-linguistic experts.
Reflections on Biopedagogies and/of Public Health
Authors: Rail Geneviève , Jette Shannon
Published: October 2015

In this article, we offer an introduction to the special issue of Cultural Studies↔Critical Methodologies. First, we present some of our own reflections and, second, we provide an overview of the articles assembled here to advance the critical interrogation of biopedagogies and/of public health. Our own reflections focus attention on biocitizens and the ill-fated “rescue missions” to save bio-Others. In brief, we argue that (a) within neoliberal societies, an assemblage of private and public institutions and organizations circulate the “health imperative”; (b) this imperative leads to the creation of the fit and productive biocitizen through various market solutions; (c) this imperative leads to biomorality and the construction of the unfit, unwell, and unproductive bio-Other; (d) public health invests in rescue missions to “save” this bio-Other; and (e) public health initiatives are instrumentalized within corporate schemes to expand markets in the name of health. We then conclude our piece with thoughts on the place of cultural studies and critical methodologies in the larger project of health and social justice, while presenting an overview of the articles selected for this special issue in connection to three themes: biopedagogies and spaces, identifications, and affects/effects.
Emotions in Constitutional Institutions
Authors: Sajó András
Published: October 2015

The prevailing justification for constitutional institutions is that such institutions reflect and enable rational solutions to social problems. However, constitutions are constructed through emotionally driven processes that reflect both the public sentiments of the day and, at least to some extent, basic moral emotions. Historical examples from France and the United States demonstrate the role of such emotional processes in shaping the design of liberal constitutionalism. Further, constitutional law both sets and regulates emotional display rules; favors or disfavors certain emotional commitments; and, particularly through the formulation of fundamental human rights, reflects and shapes emotional moral judgments. The emotional contributors to constitutional design and interpretation may be called “constitutional sentiments.”
Emotion and False Memory
Authors: Kaplan Robin L. , Van Damme Ilse , Levine Linda J. , Loftus Elizabeth F.
Published: October 2015

Emotional memories are vivid and lasting but not necessarily accurate. Under some conditions, emotion even increases people’s susceptibility to false memories. This review addresses when and why emotion leaves people vulnerable to misremembering events. Recent research suggests that pregoal emotions—those experienced before goal attainment or failure (e.g., hope, fear)—narrow the scope of people’s attention to information that is central to their goals. This narrow focus can impair memory for peripheral details, leaving people vulnerable to misinformation concerning those details. In contrast, postgoal emotions—those experienced after goal attainment or failure (e.g., happiness, sadness)—broaden the scope of attention leaving people more resistant to misinformation. Implications for legal contexts, such as emotion-related errors in eyewitness testimony, are discussed.
Incident and prevalent cohorts with pulmonary arterial hypertension: insight from SERAPHIN
Authors: Simonneau Gérald , Channick Richard N. , Delcroix Marion , Galiè Nazzareno , Ghofrani Hossein-Ardeschir , Jansa Pavel , Le Brun Franck-Olivier , Mehta Sanjay , Perchenet Loic , Pulido Tomás , Sastry B.K.S. , Sitbon Olivier , Souza Rogério , Torbicki Adam , Rubin Lewis J.
Published: October 2015

In SERAPHIN, a long-term, randomised, controlled trial (NCT00660179) in pulmonary arterial hypertension (PAH), macitentan significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisation. We evaluated disease progression and the effect of macitentan in treatment-naïve incident and prevalent cohorts.

Patients allocated to placebo, or macitentan 3 mg or 10 mg were classified by time from diagnosis to enrolment as incident (≤6 months; n=110) or prevalent (>6 months; n=157). The risk of morbidity/mortality and PAH-related death/hospitalisation was determined using Cox regression.

The risk of morbidity/mortality (Kaplan–Meier estimates at month 12: 54.4%versus26.7%; p=0.006) and PAH-related death/hospitalisation (Kaplan–Meier estimates at month 12: 47.3%versus19.9%; p=0.006) were significantly higher for incidentversusprevalent patients receiving placebo, respectively. There was no significant difference in the risk of all-cause death between incident and prevalent cohorts (p=0.587). Macitentan 10 mg significantly reduced the risk of morbidity/mortality and PAH-related death/hospitalisationversusplacebo in incident and prevalent cohorts.

Incident patients had a higher risk for PAH progression compared with prevalent patients but not a higher risk of death. Macitentan delayed disease progression in both incident and prevalent PAH patients.
CC-chemokine ligand 2 inhibition in idiopathic pulmonary fibrosis: a phase 2 trial of carlumab
Authors: Raghu Ganesh , Martinez Fernando J. , Brown Kevin K. , Costabel Ulrich , Cottin Vincent , Wells Athol U. , Lancaster Lisa , Gibson Kevin F. , Haddad Tarik , Agarwal Prasheen , Mack Michael , Dasgupta Bidisha , Nnane Ivo P. , Flavin Susan K. , Barnathan Elliot S.
Published: October 2015

The objective of this study was to determine the safety and efficacy of carlumab in the treatment of idiopathic pulmonary fibrosis (IPF).

A phase 2, randomised, double-blind placebo-controlled dose-ranging study was conducted in patients with IPF (n=126). Patients were randomised to carlumab (1 mg·kg−1, 5 mg·kg−1, or 15 mg·kg−1) or placebo every 4 weeks. The primary endpoint was the rate of percentage change in forced vital capacity (FVC). Secondary endpoints were time to disease progression, absolute change in FVC, relative change in diffusing capacity of the lung for carbon monoxide (DLCO), and St George's Respiratory Questionnaire (SGRQ) total score.

Due to a pre-planned, unfavourable interim benefit–risk analysis, dosing was suspended. The rate of percentage change in FVC showed no treatment effect (placebo −0.582%, 1 mg·kg−1−0.533%, 5 mg·kg−1−0.799% and 15 mg·kg−1−0.470%; p=0.261). All active treatment groups showed a greater decline in FVC (1 mg·kg−1−290 mL, 5 mg·kg−1−370 mL and 15 mg·kg−1−320 mL) compared with placebo (−130 mL). No effect on disease progression,DLCO, infection rates or mortality was observed. SGRQ scores showed a nonsignificant trend toward worsening with active treatment. Unexpectedly, free CC-chemokine ligand 2 levels were elevated above baseline at both 24 and 52 weeks. A higher proportion of patients with one or more serious adverse events was observed in the 5 mg·kg−1group (53.1%) compared with 1 mg·kg−1(15.2%), 15 mg·kg−1(21.9%) and placebo (46.4%), although no unexpected serious adverse events were noted.

Although dosing was stopped prematurely, it is unlikely that carlumab provides benefit to IPF patients.
Enhanced angiogenesis in ischemic skeletal muscle after transplantation of cell sheets from baculovirus-transduced adipose-derived stromal cells expressing VEGF165
Authors: Makarevich Pavel I. , Boldyreva Maria A. , Gluhanyuk Evgeny V. , Efimenko Anastasia Yu , Dergilev Konstantin V. , Shevchenko Evgeny K. , Sharonov Georgy V. , Gallinger Julia O. , Rodina Polina A. , Sarkisyan Stepan S. , Hu Yu-Chen , Parfyonova Yelena V.
Published: October 2015

Introduction

Cell therapy using adipose-derived stromal cells (ADSC) is an intensively developing approach to promote angiogenesis and regeneration. Administration technique is crucial and among others minimal constructs - cell sheets (CS) have certain advantages. Delivery of CS allows transplantation of cells along with matrix proteins to facilitate engraftment. Cells’ therapeutic potential can be also increased by expression of proangiogenic factors by viral transduction. In this work we report on therapeutic efficacy of CS from mouse ADSC transduced to express human vascular endothelial growth factor 165 a/a isoform (VEGF165), which showed potency to restore perfusion and protect tissue in a model of limb ischemia.

Methods

Mouse ADSC (mADSC) isolated from C57 male mice were expanded for CS formation (106cells per CS). Constructs were transduced to express human VEGF165 by baculoviral (BV) system. CS were transplanted subcutaneously to mice with surgically induced limb ischemia and followed by laser Doppler perfusion measurements. At endpoint animals were sacrificed and skeletal muscle was evaluated for necrosis and vessel density; CS with underlying muscle was stained for apoptosis, proliferation, monocytes and blood vessels.

Results

Using BV system and sodium butyrate treatment we expressed human VEGF165 in mADSC (production of VEGF165 reached ≈ 25-27 ng/ml/105 cells) and optimized conditions to ensure cells’ viability after transduction. Implantation of mock-transduced CS resulted in significant improvement of limb perfusion, increased capillary density and necrosis reduction at 2 weeks post-surgery compared to untreated animals. Additional improvement of blood flow and angiogenesis was observed after transplantation of VEGF165-expressing CS indicating enhanced therapeutic potential of genetically modified constructs. Moreover, we found delivery of mADSC as CS to be superior to equivalent dose of suspended cells in terms of perfusion and angiogenesis. Histology analysis of extracted CS detected limited proliferation and approximately 10 % prevalence of apoptosis in transplanted mADSC. Significant vascularization of CS and infiltration by monocytes were found in both – BV-transduced and control CS indicating graft and host interaction after transplantation.

Conclusions

Delivery of ADSC by subcutaneous transplantation of CS is effective for stimulation of angiogenesis and tissue protection in limb ischemia with a potential for efficacy improvement by BV transduction to express VEGF165.
A large and diverse collection of bovine genome sequences from the Canadian Cattle Genome Project
Authors: Stothard Paul , Liao Xiaoping , Arantes Adriano S. , De Pauw Mary , Coros Colin , Plastow Graham S. , Sargolzaei Mehdi , Crowley John J. , Basarab John A. , Schenkel Flavio , Moore Stephen , Miller Stephen P.
Published: October 2015

Background

The Canadian Cattle Genome Project is a large-scale international project that aims to develop genomics-based tools to enhance the efficiency and sustainability of beef and dairy production. Obtaining DNA sequence information is an important part of achieving this goal as it facilitates efforts to associate specific DNA differences with phenotypic variation. These associations can be used to guide breeding decisions and provide valuable insight into the molecular basis of traits.

Findings

We describe a dataset of 379 whole-genome sequences, taken primarily from key historic Bos taurus animals, along with the analyses that were performed to assess data quality. The sequenced animals represent ten populations relevant to beef or dairy production. Animal information (name, breed, population), sequence data metrics (mapping rate, depth, concordance), and sequence repository identifiers (NCBI BioProject and BioSample IDs) are provided to enable others to access and exploit this sequence information.

Conclusions

The large number of whole-genome sequences generated as a result of this project will contribute to ongoing work aiming to catalogue the variation that exists in cattle as well as efforts to improve traits through genotype-guided selection. Studies of gene function, population structure, and sequence evolution are also likely to benefit from the availability of this resource.
Complete genome sequence of Propionibacterium freudenreichii DSM 20271T
Authors: Koskinen Patrik , Deptula Paulina , Smolander Olli-Pekka , Tamene Fitsum , Kammonen Juhana , Savijoki Kirsi , Paulin Lars , Piironen Vieno , Auvinen Petri , Varmanen Pekka
Published: October 2015

Propionibacterium freudenreichii subsp. freudenreichii DSM 20271T is the type strain of species Propionibacterium freudenreichii that has a long history of safe use in the production dairy products and B12 vitamin. P. freudenreichii is the type species of the genus Propionibacterium which contains Gram-positive, non-motile and non-sporeforming bacteria with a high G + C content. We describe the genome of P. freudenreichii subsp. freudenreichii DSM 20271T consisting of a 2,649,166 bp chromosome containing 2320 protein-coding genes and 50 RNA-only encoding genes.
Do phages impact microbial dynamics, prokaryotic community structure and nutrient dynamics in Lake Bourget?
Authors: Meunier Antony , Jacquet Stéphan
Published: October 2015

Phages are the most abundant and diversified biological entities in aquatic ecosystems. Understanding their functional role requires laboratory experiments on a short time-scale. Using samples of surface waters of Lake Bourget, we studied whether viruses impact (i) the abundance patterns of the bacterial and phytoplankton communities, (ii) a part of the prokaryotic community composition (both for Eubacteria and Archaea), and (iii) the recycling of nutrients and/or organic matter. Three experiments were performed (one each in February, March and April) at the transition between winter and spring in 2013. The experiment reduced or increased the abundance of virus-like particles in samples containing only the picoplanktonic fraction. Viral and cellular abundances, bacterial and archaeal community structures as well as nutrient concentrations were analysed every 24 h for 3 days. Some of the results reveal that increasing the phage abundance increased the diversity of the eubacterial community. Consistent with the ‘killing the winner’ concept, viruses are thus likely to significantly change the composition of the bacterial community. This suggests a positive association between viral abundance and bacterial diversity. In contrast, the composition of the archaeal community did not seem to be affected by phage abundance, suggesting the absence of viral control on this community or the inability to observe it at this period of year, either based on the time scale of the investigation or because the archaeal virus titre was too low to induce a significant and visible effect. Lastly, we were unable to demonstrate viruses driving the cycling of nutrients or the response of plankton to nutrient concentration changes in a significant way, suggesting that the role of viruses may be subtle or difficult to assess through the use of such experimental procedures.
Stochastic and chaotic dynamics evaluation parameters of cardiovascular system in human transshirotnyh transfer
Authors: Пахомов  , Pakhomov A. , Прасолова  , Prasolova A. , Козлова  , Kozlova V. , Сорокина  , Sorokina A.
Published: October 2015

Using the methods of statistical analysis and methods of multidimensional phase spaces (analysis and calculation of the volume of quasi-attractors matrices mezhattraktornyh distances) studied the behavior of the state vector of the body girls (for example, the behavior of the parameters of the cardiovascular system) with transshirotnyh movements. The differences in the assessment of the dynamic behavior of the parameters of the cardio-vascular system, namely the decrease in quasi-attractors indicates good revitalizing effect two-week stay in a boarding house young children oilman. Analysis matrices mezhattraktonyh distances showed that the motion of chaotic and stochastic centers at latitude movements somewhat different girls: mezhattraktornye distance when driving chaotic center upon arrival to rest down, after a two-week vacation, it becomes even more, to return to the city of Surgut is similar to the results for the arrival at rest, indicating the lack of formation of the girls adaptive mechanisms, as well as a significant tension of regulatory processes and the degree of mismatch of functional systems at transshirotnyh movements.
Analysis of the parameters of the neuroautonomic systems state vector of workers of gas condensate stabilization factory who are exposed to electromagnetic radiation industrial frequency
Authors: Нигматуллин  , Nigmatullin D. , Файзуллина  , Fayzullina I. , Болтаев  , Boltaev A. , Газя  , Gazya G.
Published: October 2015

After comparative analysis of the parameters of the autonomic nervous system oil and gas industry workers using the methods of parametric and non-parametric statistics, as well as the method of chaos theory and of self-organization. It was possible to determine the degree of tension of autonomic functions in the body of workers. Parameters of an organism in the environment of workers to electromagnetic fields were analyzed. This physical factor affects to older women (35 years) and to younger men (under 35 years) more than other.
Projeto Comunidade em Movimento: a experiência multiprofissional na Atenção Primária à Saúde
Authors: Ravagnani Christianne , Silva Valdemar , Mota Reinaldo , Ribeiro Maria , Arcoverde Rosele , Holland Maria , Perdomo Letícia
Published: October 2015

O Projeto Comunidade em Movimento, vinculado ao Programa Pró-PetSaúde do Ministério da Saúde é um modelo de intervenção multiprofissional de base comunitária desenvolvido na Estratégia Saúde da Família de Cuiabá. Voltado à promoção da saúde e prevenção das doenças crônicas não transmissíveis em consonância com as diretrizes das políticas governamentais que enfatizam as práticas corporais e a alimentação saudável o projeto oferece exercícios físicos supervisionados (2x/semana), educação em saúde, estruturação e estímulo dos conselhos gestores e outras atividades desenvolvidas por alunos, profissionais do serviço e docentes dos cursos de Educação Física, Enfermagem, Medicina, Nutrição, Saúde Coletiva e Serviço Social. Esperamos que intervenções como esta sirvam de modelo para os profissionais, gestores da saúde e universidades.
Infusion pump development and implications for nurses
Authors: Lee Paul
Published: October 2015

Infusion pumps are commonplace in today's healthcare settings and their design and development has kept pace with technology over the decades. In the 1970s and 1980s infusion pumps began to emerge in the UK market and were basic, mechanical devices with limited functions. Today, infusion pumps have a plethora of functions and features and a range of alarms to help alert the user and the patient that infusions are nearing completion, have ended or their range of sensors has detected that the infusion pump, or patient, requires attention. The role of the nurse in safely managing this ever-changing technology should not be underestimated. This paper reviews the progress made over the past 40 years in the UK healthcare setting and how the nurses have had to keep up to speed with the technology as it develops. It highlights the importance of fully integrating infusion pumps into intravenous (IV) therapy training and assessment. The important role the nurse plays is highlighted as well as exploring how he or she can help organisations better understand infusion pumps in the day-to-day management of patients undergoing intravenous therapy.
UK national survey of management of breast lobular carcinoma in situ
Authors: Chester R , Bokinni O , Ahmed I , Kasem A
Published: October 2015

Introduction

There is no national standard treatment for patients with breast lobular carcinoma in situ (LCIS). Association of Breast Surgery guidelines for the management of breast cancer suggest that lesions containing LCIS should be excised for definitive diagnosis and recommend close surveillance after excision biopsy. The aim of this study was to form a picture of the current management of LCIS by UK breast surgeons.

Methods

A questionnaire about the management of LCIS was sent to 490 UK breast surgeons.

Results

Of 490 questionnaires sent out, 173 (35%) were returned. When LCIS is present in a core biopsy, 61% of breast surgeons perform surgical excision, 22% would not excise but would continue follow-up and the remainder perform neither or set no clear management plan. Over half (54%) follow patients up with five years of annual mammography. If classic LCIS were found at the margins of wide local excision, 92% would not re-excise. Conversely, if pleomorphic LCIS were found, 71% would achieve clear margins. Respondents were split evenly regarding management of classic LCIS with a family history as 54% would not alter management whereas 43% would treat the disease more aggressively.

Conclusions

Our survey has shown that in cases where LCIS is found at core biopsy, most surgeons follow Association of Breast Surgery guidance, obtaining further histological samples to exclude pleomorphic LCIS, ductal carcinoma in situ or invasive cancer, whereas others opt for annual surveillance and some discharge the patient. This study highlighted the huge variability in LCIS management, and the need for randomised controlled trials and input into national audits such as the Sloane Project to establish evidence-based national standard guidelines.
Determination of a safe INR for joint injections in patients taking warfarin
Authors: Bashir MA , Ray R , Sarda P , Li S , Corbett S
Published: October 2015

Introduction

With an increase in life expectancy in ‘developed’ countries, the number of elderly patients receiving joint injections for arthritis is increasing. There are legitimate concerns about an increased risk of thromboembolism if anticoagulation is stopped or reversed for such an injection. Despite being a common dilemma, the literature on this issue is scarce.

Methods

We undertook 2,084 joint injections of the knee and shoulder in 1,714 patients between August 2008 and December 2013. Within this cohort, we noted 41 patients who were taking warfarin and followed them immediately after joint injection in the clinic or radiology department, looking carefully for complications. Then, we sought clinical follow-up, correspondence, and imaging evidence for 4 weeks, looking for complications from these joint injections. We recorded International Normalised Ratio (INR) values before injection.

Results

No complications were associated with the procedure after any joint injection. The radiologists who undertook ultrasound-guided injections to shoulders re-scanned the joints looking for haemarthroses: they found none. A similar outcome was noted clinically after injections in the outpatient setting.

Conclusion

With a mean INR of 2.77 (range, 1.7–5.5) and a maximum INR within this group of 5.5, joint injections to the shoulder and knee can be undertaken safely in primary or secondary care settings despite the patient taking warfarin.
Litigation costs of wrong-site surgery and other non-technical errors in orthopaedic operating theatres
Authors: Harrison WD , Narayan B , Newton AW , Banks JV , Cheung G
Published: October 2015

Introduction

This study reviews the litigation costs of avoidable errors in orthopaedic operating theatres (OOTs) in England and Wales from 1995 to 2010 using the National Health Service Litigation Authority Database.

Materials and methods

Litigation specifically against non-technical errors (NTEs) in OOTs and issues regarding obtaining adequate consent was identified and analysed for the year of incident, compensation fee, cost of legal defence, and likelihood of compensation.

Results

There were 550 claims relating to consent and NTEs in OOTs. Negligence was related to consent (n=126), wrong-site surgery (104), injuries in the OOT (54), foreign body left in situ (54), diathermy and skin-preparation burns (54), operator error (40), incorrect equipment (25), medication errors (15) and tourniquet injuries (10). Mean cost per claim was £40,322. Cumulative cost for all cases was £20 million. Wrong-site surgery was error that elicited the most successful litigation (89% of cases). Litigation relating to implantation of an incorrect prosthesis (eg right-sided prosthesis in a left knee) cost £2.9 million. Prevalence of litigation against NTEs has declined since 2007.

Conclusions

Improved patient-safety strategies such as the World Health Organization Surgical Checklist may be responsible for the recent reduction in prevalence of litigation for NTEs. However, addition of a specific feature in orthopaedic surgery, an ‘implant time-out’ could translate into a cost benefit for National Health Service hospital trusts and improve patient safety.
Ordinary transvestitism: Imaginary body–real body in contemporary fashion
Authors: Versel Martine , Busquets Joan
Published: October 2015

The study we are proposing here concerns the transition between clothes and the images that they convey. At the same time, we have given thought to the body and on the way in which it becomes incarnated in contemporary fashion. From a semiotic point of view, we are situated in a perspective which has been a little bit forgotten, by drawing on the category of Barthesian semblance and by questioning it in the light of new data. More precisely, our semiotic approach has been carried out by adopting other disciplines such as psychoanalysis, philosophy and Kabuki theatre (in this case, the character of onnagata). To do this, we have chosen to grasp what is at play concerning the body in present-day ready-to-wear clothes. To illustrate our remarks, we have based our work on a particular example, that being the universe of Yves Saint Laurent’s (YSL) house of fashion, more precisely their 2012 Men’s collection. In fact, these clothes reveal that what we see is within the realm of appearance, but, at the same time, they show that they are the appearance of the appearance. Indicating a radical dissociation between clothes and gender, YSL opens the enigma of One-body. This designer strips the gaze which refers less to the imaginary body and the gender comedy than the enigma of the real body defined in the psychoanalytic field.
Deconstruction in contemporary fashion design: Analysis and critique
Authors: Zborowska Agata
Published: October 2015

One of the most important phenomena in fashion, which practically forced the researchers to rethink their former language, is deconstruction. Appearing almost in parallel with deconstruction in architecture it uncovered previously unseen fissure in the discourse used in constructing the object of research. Deconstruction is usually described as one of the many fast-changing trends in fashion, but fashion scholars rarely pay attention to the sources or consequences of this trend. This study constitutes an attempt to develop such a historical and theoretical take on deconstruction in fashion, to analyse its descriptions and conceptualizations. For this purpose, the author reconstructs the sources of this phenomenon in fashion, with particular attention being paid to two fashion houses: Maison Martin Margiela and Comme des Garçons. To situate deconstruction in a broader context, the article refers to this term in the philosophy as well as the architecture and the graphic design. The last part of the article is devoted to alternative theoretical perspectives – the conceptions of Michel de Certeau and John Fiske – which are used to look again at deconstruction in the context of youth subcultures and its importance in the contemporary fashion system.
CD200/CD200R Paired Potent Inhibitory Molecules Regulating Immune and Inflammatory Responses; Part II : CD 200/CD200R Potential Clinical Applications
Authors: Holmannová Drahomíra , Koláčková Martina , Kondělková Kateřina , Kuneš Pavel , Krejsek Jan , Andrýs Ctirad
Published: October 2015

CD200 and its receptor were recognized as having the multiple immunoregulatory functions. Their immunoregulatory, suppressive, and tolerogenic potentials could be very effectively exploited in the treatment of many diseases, e.g. Alzheimer disease, rheumatoid arthritis, and allergy to name only some. Many research projects are aimed to develop clinically valuable methods being based on the structure and function of these paired molecules. In this review, we would like to introduce CD200/CD200R functions in a clinical context.
Serum Homocysteine Levels in Czech Children and Adolescents
Authors: Němec Vladimír , Bočkayová Eva , Kutílek Štěpán
Published: October 2015

Aim: The principal aim was to establish reference paediatric data for the serum homocysteine levels in Czech children and adolescents. Methods and Results: 144 children either healthy or not sufferig from acute or chronic inflammation, autoimmune disorders including rheumatic diseases, inflammatory musculoskeletal disorders, inflammatory bowel disease, diabetes mellitus, hypercholesterolemia, epilepsy, chronic renal failure, aged 0–19.9 years (0–6.9 years, n = 40; 7–10.9 y, n = 28; 11–15.9 y, n = 45; 16–19.9 y, n = 31) had their blood samples collected and the serum homocysteine level (S-homocysteine) was evaluated by chemiluminescence. A significant age dependence of the S-homocysteine levels was observed (R = 0.35, p < 0.01); with highest values of upper reference range in the 11–15.9 and 16–19.9 years’ group, respectively. Conclusion: The establishment of S-homocysteine reference Czech pediatric values is a potentially useful tool for proper evaluation of elevated homocysteine levels and corresponding risks in childhood.
The Ability of Oxime Mixtures to Increase the Reactivating and Therapeutic Efficacy of Antidotal Treatment of Cyclosarin Poisoning in Rats and Mice
Authors: Kassa Jiří , Karasová Jana Zdarová , Pavlíková Růžena , Caisberger Filip , Bajgar Jiří
Published: October 2015

The reactivating and therapeutic efficacy of two combinations of oximes (HI‑6 + trimedoxime and HI‑6 + K203) was compared with the effectiveness of antidotal treatment involving single oxime (HI‑6, trimedoxime, K203) using in vivo methods. In vivo determined percentage of reactivation of cyclosarin‑inhibited blood and tissue acetylcholinesterase in poisoned rats showed that the reactivating efficacy of both combinations of oximes is slightly higher than the reactivating efficacy of the most effective individual oxime in blood, diaphragm as well as in brain. Moreover, both combinations of oximes were found to be slightly more efficacious in the reduction of acute lethal toxic effects in cyclosarin‑poisoned mice than the antidotal treatment involving single oxime. Based on the obtained data, we can conclude that the antidotal treatment involving chosen combinations of oximes brings a beneficial effect for its ability to counteract the acute poisoning with cyclosarin.