bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Weld Strength Heterogeneity on Crack Driving Force in Stress and Strain Based Design Scenarios
Authors: Hertelé Stijn , O’Dowd Noel , Verstraete Matthias , Van Minnebruggen Koen , De Waele Wim
Published: December 2014

Weld strength mismatch is a key factor with respect to the assessment of a flawed girth weld. However, it is challenging to assign a single strength mismatch value to girth welds, which are generally heterogeneous in terms of constitutive behavior. The authors have recently developed a method (‘homogenization’) to account for weld strength property variations in the estimation of crack driving force response and the corresponding tensile limit state. This paper separately validates the approach for stress based and strain based assessments. Whereas homogenization is reliably applicable for stress based assessments, the strain based crack driving force response is highly sensitive to effects of actual heterogeneous weld properties. The sensitivity increases with increased weld width and decreased strain hardening behavior. For strain based design, a more accurate methodology is desirable, and large scale testing and/or advanced numerical modeling remain essential.
Qualification Testing of Mechanical Pipe Joining Method
Authors: McColl Dave , Whiting Adam
Published: December 2014

Pipeline infrastructure is the backbone of the energy industry and remains the safest and most cost effective method for transporting oil and gas. For decades corrosion has presented a significant challenge to pipeline operators. According to Alberta Energy Regulator data, internal corrosion is considered to be the root cause for more than 54% of all documented pipeline failures in Alberta [1]. Spoolable composite pipeline technologies have become a mainstream corrosion solution over the last 10 years, however these products are limited to smaller pipelines, typically less than 6 inches in diameter. Traditional slip-lining (field installed plastic lined steel pipe) is used for internal corrosion protection of larger pipelines, however it is costly, requiring labour intensive field construction, often completed in inhospitable environmental conditions. As a result project delays and cost over-runs are commonplace.

Recognizing the need for a cost effective pipeline corrosion solution for larger gathering pipelines, an innovative technology was developed that combines a unique mechanical pipe joining system with an integrated electro-fusion coupler. The new joining system enables insertion of an HDPE liner in a factory environment where costs and quality can be tightly controlled. The new joining system eliminates conventional welding of the pipeline in the field and instead uses a custom field press to quickly energize the mechanical pipe joint. Field scope is significantly reduced, construction completed in less time, and associated costs greatly reduced. This paper discusses the testing completed to qualify the new joining system for use in oilfield gathering pipelines.

The qualification test plan includes all requirements identified in applicable regulatory standards (primarily CSA Z662-11), and prudent engineering requirements based on anticipated field handling and anticipated operating conditions. The test regime was ultimately designed to ensure the suitability of the pipeline system for intended service. Testing included hydrostatic burst, static gas pressure, bend, cyclic pressure and thermal, vacuum, tensile, and compressive tests on the joint.

The test results show that in all cases the jointing system successfully met the established design performance criteria and in most cases exceeded the actual mechanical properties of the parent pipe, thus proving the joining system ready for field installations.
Probability of Brittle Fracture in Gas Pipelines
Authors: Kurth R. , Kalyanam S. , Kurth E. , Wilkowski G. , Brust F. , Hattery G.
Published: December 2014

This is a report of the calculation of the probability of brittle fracture and crack arrest for a series of X42 A-series and B-series pipelines. This paper provides the probabilistic analysis to determine the probability distribution of crack propagation velocities using the material resistance developed from Charpy and Drop Weight Tear Tests (DWTT).
“It’s Supposed to be About the Love of the Game, not the Love of Aaron Rodgers’ Eyes”: Challenging the Exclusions of Women Sports Fans
Authors: Esmonde Katelyn , Cooky Cheryl , Andrews David L.
Published: December 2014

Feminist sports scholars characterize sport as a masculine domain wherein the ideology of male superiority and dominance is structurally and symbolically perpetuated. Researchers similarly identify sports fan communities as exclusionary to women and sites for the reaffirmation of gendered hierarchies. The purpose of this project is to examine the gendered meanings of sports fandom. Using semistructured interviews with eleven women who identify as fans of sports at the institutional center, we find the narratives illustrate the complex ways women define themselves in to, or define themselves out of, dominant discourses of sports fandom. The third wave feminist sensibilities employed in our analysis, and in the narrative experiences of our participants, compel us to recognize and struggle with the seeming contradictions of women sports fans. By giving voice to women sports fans, we offer a feminist intervention into the exclusionary processes that marginalize women’s sports fans.
Substitution effects and electronic properties of the azo dye (1-phenylazo-2-naphthol) species: a TD-DFT electronic spectra investigation
Authors: Mansouri Lakhdar , Zouchoune Bachir
Published: December 2014

DFT/B3LYP and ab initio Hartree–Fock calculations with full geometry optimization have been carried out on hydrazo and azo forms of 1-phenylazo-2-naphthol and their substituted derivatives. The predicted geometries show that a small energy difference of 1.8 kcal/mol might tune the equilibrium between both forms. Depending on the electron donating and electron accepting of the different used substituents (CF3, NH2, CH3, Cl, and NO2), the various obtained isomers show small energy differencies between meta and para substitution except for the NH2 one, indicating the coexistence of the tautomers in solution. The ortho(C12) position was found to be the less favored substitution in all cases, while the second ortho(C16) position for different substituents provides isomers competing with the most stable meta and para ones. The obtained results suggest that a judicious choice in the substituents’ use on the phenyl ring should lead to stabilization. The TD-DFT theoretical study performed on the optimized geometry allowed us to identify quite clearly the spectral position and the nature of the different electronic transitions according to their molecular orbital localization, hence, reproducing the available UV-Vis spectra. The increase in the wavelength values is in perfect agreement with red shifts and the ΔE (ELUMO – EHOMO) decreasing. Thus, from the point of view of both substitution and the used solvent, the obtained electronic spectra appear to behave quite differently.
Chinese fir root response to spatial and temporal heterogeneity of phosphorus availability in the soil
Authors: Zou Xianhua , Wu Pengfei , Chen Nailian , Wang Pan , Ma Xiangqing
Published: December 2014

Deficiency in availability of phosphorus (P) in forest soils of southern China, where Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) stands have been established, greatly affects Chinese fir productivity. Deploying clones with high P-use efficiency could be a more attractive option than P fertilization to enhance the commercial productivity of Chinese fir. Thus, an understanding of the adaptive responses of roots to spatiotemporal variability of P, which is often ignored in previous studies, is essential. In this study, we report the root responses of a Chinese fir clone with high P-use efficiency to the spatially heterogeneous P availability in soil during various periods of time when P availability was controlled. The results showed significantly (p < 0.05) more root proliferation in the form of root length, root surface area, root volume, and root dry matter accumulation in P-replete than in P-poor patches when the patch persisted for a short period of time (50 days). As the patches persisted longer (100–200 days), root proliferation in P-replete patches appeared to decline. P-replete patches that persisted for short (50 days) and long (200 days) periods resulted in high root P accumulation, whereas P-replete patches that persisted for 100–150 days resulted in lower root P accumulation than other patches. It seems that the observed responses in the roots of the Chinese fir clone to heterogeneous P availability might include a comprehensive adjustment of root growth and intraroot P translocation in patches so as to maintain internal P homeostasis, as well as a trade-off between energy cost and production of new roots when the patch persists longer.
Vitamin D receptor, a tumor suppressor in skin
Authors: Bikle Daniel D.
Published: December 2014

Vitamin D and calcium are well-established regulators of keratinocyte proliferation and differentiation. Therefore, it was not a great surprise that deletion of the vitamin D receptor (VDR) should predispose the skin to tumor formation, and that the combination of deleting both the VDR and calcium sensing receptor (CaSR) should be especially pro-oncogenic. In this review I have examined 4 mechanisms that appear to underlie the means by which VDR acts as a tumor suppressor in skin. First, DNA damage repair is curtailed in the absence of the VDR, allowing mutations in DNA to accumulate. Second and third involve the increased activation of the hedgehog and β-catenin pathways in the epidermis in the absence of the VDR, leading to poorly regulated proliferation with reduced differentiation. Finally, VDR deletion leads to a shift in the expression of long noncoding RNAs toward a more oncogenic profile. How these different mechanisms interact and their relative importance in the predisposition of the VDR null epidermis to tumor formation remain under active investigation.
Recommendations for the Long-Term Treatment of Psoriasis with Infliximab: A Dermatology Expert Group Consensus
Authors: Reich Kristian , Griffiths Christopher , Barker Jonathan , Chimenti Sergio , Daudén Esteban , Giannetti Alberto , Gniadecki Robert , Katsambas Andreas , Langley Richard , Mrowietz Ulrich , Ogilvie Alexandra , Ortonne Jean-Paul , Reider Norbert , Saurat Jean-Hilaire
Published: December 2014

Background/Aims: Infliximab has been approved for the treatment of chronic plaque psoriasis for only a few years. As physicians gain confidence in initiating and maintaining this therapy, guidance on the management of patients beyond several months or years is needed. To date, there is little or no information about the long-term management in clinical trials or guidelines. Methods: Here we report on the key aspects related to the use of infliximab for the treatment of psoriasis. The data presented here were derived using a modified Delphi survey to obtain a consensus opinion of 11 dermatologists from Europe and Canada experienced in long-term therapy with infliximab. Results/Conclusion: The Delphi participants reviewed several important topics related to biological therapy and infliximab. This paper is not intended to provide a recommendation on all practical aspects related to biological therapy; it has rather been written to provide useful and practical information on the ‘best practice’ use of infliximab.
Cardiovascular Disease Mortality and Cancer Incidence in Vegetarians: A Meta-Analysis and Systematic Review
Authors: Huang Tao , Yang Bin , Zheng Jusheng , Li Guipu , Wahlqvist Mark L. , Li Duo
Published: December 2014

Background: Prospective cohort studies have examined mortality and overall cancer incidence among vegetarians, but the results have been inconclusive. Aims: The objective of the present meta-analysis was to investigate cardiovascular disease mortality and cancer incidence among vegetarians and nonvegetarians. Methods: Medline, EMBASE and Web Of Science databases were searched for cohort studies published from inception to September 2011. Studies were included if they contained the relative risk (RR) and corresponding 95% CI. Participants were from the UK, Germany, California, USA, the Netherlands and Japan. Results: Seven studies with a total of 124,706 participants were included in this analysis. All-cause mortality in vegetarians was 9% lower than in nonvegetarians (RR = 0.91; 95% CI, 0.66–1.16). The mortality from ischemic heart disease was significantly lower in vegetarians than in nonvegetarians (RR = 0.71; 95% CI, 0.56–0.87). We observed a 16% lower mortality from circulatory diseases (RR = 0.84; 95% CI, 0.54–1.14) and a 12% lower mortality from cerebrovascular disease (RR = 0.88; 95% CI, 0.70–1.06) in vegetarians compared with nonvegetarians. Vegetarians had a significantly lower cancer incidence than nonvegetarians (RR = 0.82; 95% CI, 0.67–0.97). Conclusions: Our results suggest that vegetarians have a significantly lower ischemic heart disease mortality (29%) and overall cancer incidence (18%) than nonvegetarians.
Outcome of Bipolar Electrocoagulation with Lesionectomy in the Treatment of Epilepsy Involving Eloquent Areas
Authors: Zhai Feng , Zhou Jian , Li Tianfu , Cui Zhiqiang , Luan Guoming
Published: December 2014

Background/Aims: We have demonstrated previously that bipolar electrocoagulation on functional cortex (BCFC) is a safe and effective approach for epilepsy involving eloquent areas. Here, we report the results of BCFC with lesionectomy for patients with epileptogenic foci partially overlapping eloquent areas. Methods: Forty patients who had been treated with lesionectomy with BCFC were retrospectively reviewed with regard to seizure outcome and neurological deficits. Ten similar patients who had received lesionectomy with multiple subpial transections (MST) were examined as a control group. Results: In the lesionectomy group with BCFC, Engel class I was achieved in 18 (45%) patients, class II in 8 (20%) patients, class III in 8 (20%) patients and class IV in 6 (15%) patients. Five (12.5%) patients developed mild hemiparesis and 1 (2.5%) patient mild sensory dysphasia. In the lesionectomy group with MST, Engel class I was achieved in 3 (30%) patients, class II in 2 (20%) patients, class III in 3 (30%) patients and class IV in 2 (20%) patients. Two (20%) patients developed mild hemiparesis and 1 (10%) patient moderate hemiparesis. All these complications recovered within 1-12 months. Conclusions: Compared with MST, the outcome of BCFC with lesionectomy is similar. But since MST leads to mechanical injury, while BCFC causes thermal injury, the complications of BCFC seem less severe. © 2014 S. Karger AG, Basel
Benefit of a Contralateral Routing of Signal Device for Unilateral Cochlear Implant Users
Authors: Weder Stefan , Kompis Martin , Caversaccio Marco , Stieger Christof
Published: December 2014

Objective: To investigate objective and subjective effects of an adjunctive contralateral routing of signal (CROS) device at the untreated ear in patients with a unilateral cochlear implant (CI). Design: Prospective study of 10 adult experienced unilateral CI users with bilateral severe-to-profound hearing loss. Speech in noise reception (SNR) and sound localization were measured with and without the additional CROS device. SNR was measured by applying speech signals at the untreated/CROS side while noise signals came from the front (S90N0). For S0N90, signal sources were switched. Sound localization was measured in a 12-loudspeaker full circle setup. To evaluate the subjective benefit, patients tried the device for 2 weeks at home, then filled out the abbreviated Speech, Spatial and Qualities of Hearing Scale as well as the Bern benefit in single-sided deafness questionnaires. Results: In the setting S90N0, all patients showed a highly significant SNR improvement when wearing the additional CROS device (mean 6.4 dB, p < 0.001). In the unfavorable setting S0N90, only a minor deterioration of speech understanding was noted (mean -0.66 dB, p = 0.54). Sound localization did not improve substantially with CROS. In the two questionnaires, 12 of 14 items showed an improvement in mean values, but none of them was statistically significant. Conclusion: Patients with unilateral CI benefit from a contralateral CROS device, particularly in a noisy environment, when speech comes from the CROS ear side. © 2014 S. Karger AG, Basel
Polypharmacy in the Elderly: A Marker of Increased Risk of Mortality in a Population-Based Prospective Study (NEDICES)
Authors: Gómez Candelas , Vega-Quiroga Saturio , Bermejo-Pareja Félix , Medrano María José , Louis Elan D. , Benito-León Julián
Published: December 2014

Background: Little information is available on the potential association between polypharmacy and risk of mortality. Objective: To determine in a population-based study whether polypharmacy is associated with increased risk of mortality in elderly persons. Methods: In this population-based, prospective study of 5,052 people aged 65 years and older (Neurological Disorders in Central Spain), current medications were recorded. Cox proportional hazards models, adjusted for sociodemographics and comorbidity factors, were used to assess the risk of death up to 13.3 years later, comparing the polypharmacy group (≥6 drugs) to those who were taking 1-5 drugs and those in a nonmedicated group (0 drugs). Results: Out of 5,052 participants, 2,550 (50.5%) died over a median follow-up of 6.5 years, including 361 (28.8%) deaths among 931 nonmedicated participants, 1,946 (51.4%) deaths among 3,787 participants taking 1-5 drugs daily, and 243 (72.8%) among 334 participants on polypharmacy. In an unadjusted Cox model, risk of mortality was increased in participants on polypharmacy [hazard ratio (HR) = 2.78, 95% confidence interval [CI]: 2.36-3.27, p < 0.001) and in those taking between 1 and 5 drugs (HR = 1.47, 95% CI: 1.31-1.64, p < 0.001) versus those who were nonmedicated (reference group). In a Cox model that adjusted for a variety of demographic factors and comorbidities, HR remained increased in participants on polypharmacy (HR = 1.83, 95% CI: 1.51-2.21, p < 0.001). Conclusion: This study provides evidence that polypharmacy is associated with increased risk of mortality in elderly people. The extent to which polypharmacy is the proximate cause rather than a marker of this increase risk remains to be determined.
Calibrating Longitudinal Cognition in Alzheimer's Disease Across Diverse Test Batteries and Datasets
Authors: Gross Alden L. , Sherva Richard , Mukherjee Shubhabrata , Newhouse Stephen , Kauwe John S.K. , Munsie Leanne M. , Waterston Leo B. , Bennett David A. , Jones Richard N. , Green Robert C. , Crane Paul K. ,   for the Alzheimer's Disease Neuroimaging Initiative, GENAROAD Consortium, and AD Genetics Consortium
Published: December 2014

Background: We sought to identify optimal approaches by calibrating longitudinal cognitive performance across studies with different neuropsychological batteries. Methods: We examined four approaches to calibrate cognitive performance in nine longitudinal studies of Alzheimer's disease (AD) (n = 10,875): (1) common test, (2) standardize and average available tests, (3) confirmatory factor analysis (CFA) with continuous indicators, and (4) CFA with categorical indicators. To compare precision, we determined the minimum sample sizes needed to detect 25% cognitive decline with 80% power. To compare criterion validity, we correlated cognitive change from each approach with 6-year changes in average cortical thickness and hippocampal volume using available MRI data from the AD Neuroimaging Initiative. Results: CFA with categorical indicators required the smallest sample size to detect 25% cognitive decline with 80% power (n = 232) compared to common test (n = 277), standardize-and-average (n = 291), and CFA with continuous indicators (n = 315) approaches. Associations with changes in biomarkers changes were the strongest for CFA with categorical indicators. Conclusions: CFA with categorical indicators demonstrated greater power to detect change and superior criterion validity compared to other approaches. It has wide applicability to directly compare cognitive performance across studies, making it a good way to obtain operational phenotypes for genetic analyses of cognitive decline among people with AD. i 2014 S. Karger AG, Basel
Insulin Resistance and Skeletal Muscle Vasculature: Significance, Assessment and Therapeutic Modulators
Authors: Manrique Camila , Sowers James R.
Published: December 2014

Overnutrition and sedentarism are closely related to the alarming incidence of obesity and type 2 diabetes mellitus (DM2) in the Western world. Resistance to the actions of insulin is a common occurrence in conditions such as obesity, hypertension and DM2. In the skeletal muscle vasculature, insulin promotes vasodilation and its own transport across the vascular wall to reach its target tissue. Furthermore, insulin resistance (IR) in the skeletal muscle vasculature results in impaired skeletal muscle glucose uptake and altered whole-body glucose homeostasis. The development of different invasive and noninvasive techniques has allowed the characterization of the actions of insulin and other vasoactive hormones in the skeletal muscle vasculature in both health and disease. Current treatment strategies for DM2 do not necessarily address the impaired effect of insulin in the vasculature. Understanding the effects of insulin and other metabolically active hormones in the vasculature should facilitate the development of new therapeutic strategies targeted at the modulation of IR and improvement of whole-body glucose tolerance. i 2014 S. Karger AG, Basel
Inhibition of Heat Shock Protein 90 with AUY922 Represses Tumor Growth in a Transgenic Mouse Model of Islet Cell Neoplasms
Authors: Fendrich Volker , Wichmann Sven , Wiese Dominik , Waldmann Jens , Lauth Matthias , Rexin Peter , L.-Lopez Carolin , Schlitt Hans J. , Bartsch Detlef K. , Lang Sven A.
Published: December 2014

Background: This study was designed to evaluate the role of heat shock protein 90 (HSP90) in tumor progression of murine islet cell tumors. Blockade of HSP90 has recently been proposed as a therapeutic target, but effects in models of islet cell tumors with AUY922, a newly developed HSP90 inhibitor, have not been examined. Material and Methods: The carcinoid cell line BON-1 and the HSP90 inhibitor AUY922 were used to determine effects on signaling and growth in vitro. In vivo transgenic RIP1-Tag2 mice, which develop islet cell neoplasms, were treated with vehicle or AUY922 (25 mg/kg/twice per week) from week 5 until death. The resected pancreata were evaluated macroscopically and microscopically by immunohistochemistry. Quantitative real-time PCR was performed for HSP90 targets with RNA from islets isolated from treated and untreated RIP1-Tag2 mice. Results: HSP90 blockade impaired constitutive and growth factor-induced signaling in vitro. Moreover, HSP90 inhibition attenuated in vitro cell growth in a dose-dependent manner. In vivo, AUY922 significantly reduced tumor volume by 92% compared to untreated controls (p = 0.000), and median survival in the used transgenic mouse model was prolonged (110 vs. 119 days; p = 0.75). Quantitative real-time PCR for downstream target genes of HSP90 demonstrated significant downregulation in the islet cell tumors of RIP1-Tag2 mice treated with AUY922, confirming our ability to achieve effective pharmacologic levels of AUY922 within the desired tissue site in vivo. Conclusion: This is the first study to show that the HSP90 antagonist AUY922 may provide a new option for therapy of islet cell neoplasms.
Endoscopic Removal of Pedunculated Leiomyoma of the Sigmoid Colon
Authors: Sato Harunobu , Mizuno Yoshihisa , Tsukamoto Tetsuya , Ichikawa Tomoaki , Kotani Yoshihito , Honda Katsuyuki , Kuroda Makoto
Published: December 2014

Background: The large bowel is a rare site for leiomyomas. Furthermore, a colonic pedunculated leiomyoma is very rare. Complete endoscopic removal of a colonic leiomyoma can be problematic because of its submucosal origin. Case Report: We report a colonic pedunculated leiomyoma that was removed by endoscopic polypectomy without complications. A 74-year-old man was referred to our hospital because of constipation. Colonoscopy demonstrated a 1-cm pedunculated polyp that was connected to a minute stalk within the sigmoid colon. It was removed by snare polypectomy. Histopathological examination demonstrated normal mucosa overlying a well-circumscribed proliferation of eosinophilic spindle cells arising in association with the muscularis mucosae. Immunohistological findings were positive for desmin and smooth muscle actin. The polyp was diagnosed as a leiomyoma. More than 9 months later, the patient remains well, with no further symptoms. Conclusion: For small, pedunculated leiomyomas, endoscopic snare polypectomy is thought to be a useful approach for both treatment and diagnosis.
Hypertensive Vasculopathy
Authors: Park Jeong Bae
Published: December 2014

An exclusive interview by Prof. Jeong Bae Park conducted with Dr. Rhian M. Touyz in Seoul while she was visiting for the Korean Society of Hypertension, May 10, 2014. In this interview, Dr. Touyz explains and describes hypertensive vasculopathy. © 2014 S. Karger AG, Basel
Diagnosis and Management of Autonomic Failure in Neurodegenerative Disorders
Authors: Sambati Luisa , Calandra-Buonaura Giovanna , Doria Andrea , Cortelli Pietro
Published: December 2014

Background: One of the hallmarks of the E-synucleinopathies is the degeneration of the autonomic nervous system. Summary: This review discusses the diagnosis and management of cardiovascular autonomic failure within the context of the E-synucleinopathies. In addition, it outlines the utility of various laboratory assessments including cardiovascular reflex tests for the differential diagnoses of these disorders, as well as general disease management strategies. Key Messages: Laboratory investigations assessing the autonomic control of the cardiovascular system are useful in the differential diagnosis of E-synucleinopathies, especially in early stages of disease. Clinical Implications: The characterization of the different features of AF in patients with E-synucleinopathies is challenging because it might help to improve the accuracy of the differential diagnosis between these diseases at onset. Further cardiovascular AF has been demonstrated to have a negative prognostic role in E-synucleinopathies, therefore an early detection of cardiovascular dysautonomia allows to positively impact the disease course guiding the appropriate therapy. i 2014 S. Karger AG, Basel
Genetics of Transfusion Recipient Alloimmunization: Can Clues from Susceptibility to Autoimmunity Pave the Way?
Authors: Tatari-Calderone Zohreh , Luban Naomi L.C. , Vukmanovic Stanislav
Published: December 2014

The search for genetic determinants of alloimmunization in sickle cell disease transfusion recipients was based on two premises: i) that polymorphisms responsible for stronger immune and/or inflammatory responses and hemoglobin βS mutation were co-selected by malaria; and ii) that stronger responder status contributes to development of lupus. We found a marker of alloimmunization in the gene encoding for Ro52 protein, also known as Sjögren syndrome antigen 1 (SSA1) and TRIM21. Surprisingly, the nature of the association was opposite of that with lupus; the same variant of a polymorphism (rs660) that was associated with lupus incidence was also associated with induction of tolerance to red blood cell antigens during early childhood. The dual function of Ro52 can explain this apparent contradiction. We propose that other lupus/autoimmunity susceptibility loci may reveal roles of additional molecules in various aspects of alloimmunization induced by transfusion as well as during pregnancy.
Interaction of Green Tea Catechins with Breast Cancer Endocrine Treatment: A Systematic Review
Authors: Yiannakopoulou Eugenia C.
Published: December 2014

Recent data have shown strong chemopreventive and possibly cancer chemotherapeutic effects of green tea polyphenols and EGCG against breast cancer. This systematic review aims to synthesize data on the possible interaction of green tea catechins with breast cancer endocrine treatment. Electronic databases were searched with the appropriate search terms. Experimental trials suggest a synergistic interaction of green tea catechins with tamoxifen or raloxifene in the treatment of estrogen receptor-positive and estrogen receptor-negative breast cancer through estrogen receptor-dependent and -independent mechanisms. No evidence of an interaction of green tea catechins with aromatase inhibitors or fulvestrant has been reported. As green tea catechins are natural compounds with a rather favorable safety profile, the strategy of co-administrating green tea catechins with tamoxifen seems to be a rational approach in chemoprevention, adjuvant and metastatic breast cancer treatment that needs further investigation. i 2014 S. Karger AG, Basel
A Mixed-Methods Feasibility Trial of Protein Kinase C Iota Inhibition with Auranofin in Asymptomatic Ovarian Cancer Patients
Authors: Jatoi Aminah , Radecki Breitkopf Carmen , Foster Nathan R. , Block Matthew S. , Grudem Megan , Wahner Hendrickson Andrea , Carlson Rachel E. , Barrette Brigitte , Karlin Nina , Fields Alan P.
Published: December 2014

Purpose: This trial was undertaken (1) to determine the feasibility of enrolling asymptomatic ovarian cancer patients with CA-125 elevation in a trial with the protein kinase C iota (PKCι) inhibitor auranofin and (2) to understand patients' perceptions of CA-125 monitoring. Methods: Asymptomatic ovarian cancer patients with CA-125 elevation received 3 mg auranofin orally twice per day and were evaluated. The patients participated in interviews about CA-125 monitoring. Results: Ten patients were enrolled in slightly over 6 months, exceeding our anticipated accrual rate. Four manifested stable CA-125 levels for 1 month or longer. The median progression-free survival was 2.8 months (95% CI: 1.3-3.8); auranofin was well tolerated. One patient had baseline and monthly CA-125 levels of 5,570, 6,085, 3,511, and 2,230 U/ml, respectively, stopped auranofin because of radiographic progression at 3 months, and manifested an increase in CA-125 to 7,168 U/ml approximately 3 months later. Patient interviews revealed (1) the important role of CA-125 in cancer monitoring, (2) ardent advocacy of CA-125 testing, and (3) an evolution toward CA-125 assuming a life of its own. Conclusions: This study showed the feasibility of enrolling asymptomatic ovarian cancer patients with CA-125 elevation in a trial with auranofin. One patient had a decline in CA-125, suggesting that PKCι inhibition merits further study in ovarian cancer. © 2014 S. Karger AG, Basel
Chromogranin A in Diagnosing and Monitoring Patients with Gastroenteropancreatic Neuroendocrine Neoplasms: A Large Series from a Single Institution
Authors: Massironi Sara , Rossi Roberta Elisa , Casazza Giovanni , Conte Dario , Ciafardini Clorinda , Galeazzi Marianna , Peracchi Maddalena
Published: December 2014

Background/Aims: Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. Patients and Methods: A total of 181 GEP-NEN patients (87 males, 94 females) with pancreatic (n = 81) and gastrointestinal neoplasms (n = 100) were included; 99 patients had grade (G)1 NENs (Ki-67 ≤2%), 57 G2 NENs (Ki-67 3-20%) and 25 G3 NENs (Ki-67 >20%); 81 patients had tumor-node-metastasis (TNM) stage I, 14 stage II, 17 stage III and 69 stage IV cancer. For every patient, CgA values were assessed at diagnosis and during follow-up. Results: At diagnosis, the CgA values were above the upper reference limit in 148 patients (82%); the median CgA levels were significantly higher in functioning than in nonfunctioning tumors (295 vs. 43 U/l; p = 0.0001) as well as significantly higher in patients with metastases than in those without metastases (324.5 vs. 42 U/l; p = 0.0001). In logistic regression analysis, baseline CgA levels were significantly associated with Ki-67 index (p < 0.0001) and TNM stage (p < 0.0001) independently of the age and sex of the patient and the primary site of the tumor. The overall 5- and 10-year survival rates were 74 and 64.5%, respectively. A low Ki-67 index, the type of treatment and an early CgA decrease after treatment were positively correlated with the survival rate. After radical surgery, 15/95 patients relapsed, and an increase in CgA values anticipated the clinical and objective disease recurrence after a period of 9-12 months. Conclusions: In GEP-NENs, plasma CgA has a significant prognostic relevance.
Successful Treatment of Septic Shock due to Spontaneous Esophageal Perforation 96 Hours after Onset by Drainage and Enteral Nutrition
Authors: Yamashita Risako , Takeno Shinsuke , Yamana Ippei , Maki Kenji , Miyake Toru , Shiwaku Hironari , Shiroshita Toyoo , Shiraishi Takeshi , Iwasaki Akinori , Yamashita Yuichi
Published: December 2014

Spontaneous esophageal perforation is relatively uncommon, but carries a high mortality rate if diagnosis or treatment is delayed. We report the case of a 68-year-old man with spontaneous esophageal perforation who was successfully treated over 96 h after onset by thoracic drainage and jejunostomy for enteral nutrition. He vomited after drinking alcohol, soon followed by epigastralgia. Heart failure was suspected on admission to another hospital. Spontaneous esophageal perforation was diagnosed 48 h after admission. Chest tube drainage was performed, but his general condition deteriorated and he was transferred to our hospital. Emergent surgery was performed and esophageal perforation combined with pyothorax and mediastinitis was identified on the left side of the lower esophagus. The left thoracic cavity was rinsed and thoracic drainage was performed. Feeding jejunostomy was performed for postoperative enteral nutrition. Effective drainage and sufficient nutrition management appear extremely valuable in treating spontaneous esophageal perforation.
Etiology and Complications of Portal Vein Thrombosis
Authors: Trebicka Jonel , Strassburg Christian P.
Published: December 2014

Background: Portal venous occlusion represents a disorder with considerable clinical relevance. The underlying causes of portal vein thrombosis (PVT) are frequently multifactorial and include malignancies, progressive chronic liver diseases, processes localized to the epigastrium and hepatobiliary system, and acquired as well as inherited thrombophilia. The three main categorical groups are malignant thrombosis, cirrhotic PVT, and non-malignant, non-cirrhotic PVT. Methods: Review of the literature. Results: The site, the extent, its chronicity, and the course of thromboses characterize a relatively heterogeneous clinical presentation and the ensuing complications in affected patients. While the occlusion of the extrahepatic portal and splenic vein likely provokes mainly complications related to portal hypertension, mesenteric venous obstruction shows a high rate of complications and mortality due to intestinal infarction. Especially in patients with liver cirrhosis, special care is warranted with regard to PVTs due to their pathogenetic role and influence on patient survival. Conclusion: This article aims to summarize the current opinion on etiologies, risk factors, and complications of this heterogeneous condition in adults.
Revision of the genus Arotes Gravenhorst (Hymenoptera: Ichneumonidae: Acaenitinae) from Japan
Authors: ITO MASATO , WATANABE KYOHEI , MAETO KAORU
Published: December 2014

Three Japanese species of the genus Arotes Gravenhorst, 1829 are revised. A new species, A. japonicus Ito & Watanabe, sp. nov., is described from the four main islands of Japan. This species can easily be distinguished from congeneric species by the black body without yellow markings and the entirely black hind tibia. Arotes sugiharai Uchida, 1934 is newly recorded from the islands of Kyushu and Tsushima, and the males of this species are described for the first time. The synonymy of A. moiwanus (Matsumura, 1912) and its color variant alboannulatus Uchida, 1928 are confirmed by DNA sequence analysis of the mitochondrial COI gene. The key to the world’s species of Arotes proposed by Castillo et al. (2011) is updated and a key to the Japanese species is provided.
The Dynamics of Baroclinic Zonal Jets*
Authors: Williams Paul D. , Kelsall Christopher W.
Published: December 2014

Multiple alternating zonal jets are a ubiquitous feature of planetary atmospheres and oceans. However, most studies to date have focused on the special case of barotropic jets. Here, the dynamics of freely evolving baroclinic jets are investigated using a two-layer quasigeostrophic annulus model with sloping topography. In a suite of 15 numerical simulations, the baroclinic Rossby radius and baroclinic Rhines scale are sampled by varying the stratification and root-mean-square eddy velocity, respectively. Small-scale eddies in the initial state evolve through geostrophic turbulence and accelerate zonally as they grow in horizontal scale, first isotropically and then anisotropically. This process leads ultimately to the formation of jets, which take about 2500 rotation periods to equilibrate. The kinetic energy spectrum of the equilibrated baroclinic zonal flow steepens from a −3 power law at small scales to a −5 power law near the jet scale. The conditions most favorable for producing multiple alternating baroclinic jets are large baroclinic Rossby radius (i.e., strong stratification) and small baroclinic Rhines scale (i.e., weak root-mean-square eddy velocity). The baroclinic jet width is diagnosed objectively and found to be 2.2–2.8 times larger than the baroclinic Rhines scale, with a best estimate of 2.5 times larger. This finding suggests that Rossby wave motions must be moving at speeds of approximately 6 times the turbulent eddy velocity in order to be capable of arresting the isotropic inverse energy cascade.
Employment transitions and the cycle of income inequality in postindustrial societies
Authors: Kwon Roy
Published: December 2014

This article presents the claim that the current transition from service to knowledge employment impacts income inequality in a manner that is comparable to the previous transition from agriculture to industry. This contention is tested by an employment transition index that calculates the difference of employment between the higher- and lower-paid sectors of the economy. The calculation of this index is consistent with Kuznets’s view that income inequality increases during the early stages of industrialization due to the presence of a small and higher-wage modern sector that encroaches on the total numbers employed in the large and lower-wage traditional sector. However, income inequality eventually declines with continued industrialization as more workers enter the modern sector of the economy. Results confirm the central argument of this study for a panel of 25 Organisation for Economic Co-operation and Development countries from 1980 to 2008. According to the findings, classical Kuznetsian variables such as sector-dualism are not significant and/or signed in unanticipated directions in their prediction of income inequality. Instead, the employment transition index returns robust negative associations with income inequality and consistently outperforms sector-dualism. Furthermore, knowledge employment returns positive and significant connections with the dependent variable net of the employment transition index. These results confirm that both between- and within-sector employment patterns are key determinants of income inequality.
Timing of norepinephrine in septic patients: NOT too little too late
Authors: Rachoin Jean-Sebastien , Dellinger Richard P
Published: December 2014

After years and years of consensus expert opinion as to mean arterial pressure (MAP) target and vasopressor choice in septic shock management, literature is now emerging that supports the MAP target of 65 mm Hg and norepinephrine as the vasopressor choice. However, the literature remains sparse as to the timing of vasopressors relative to fluid resuscitation and how MAP support is balanced between the choices of vasopressor versus fluid resuscitation. Bai and colleagues report data that reveal an association between earlier vasopressor initiation in septic shock and better outcome. Whether this is a linkage to better care, is related to improved early tissue perfusion, or relates to sparing of fluids to reach the MAP target is not yet known.
Point-of-care testing in the overcrowded emergency department – can it make a difference?
Authors: Rooney Kevin D , Schilling Ulf Martin
Published: December 2014

Emergency departments (EDs) face several challenges in maintaining consistent quality care in the face of steadily increasing public demand. Improvements in the survival rate of critically ill patients in the ED are directly related to the advancement of early recognition and treatment. Frequent episodes of overcrowding and prolonged waiting times force EDs to operate beyond their capacity and threaten to impact upon patient care. The objectives of this review are as follows: (a) to establish overcrowding as a threat to patient outcomes, person-centered care, and public safety in the ED; (b) to describe scenarios in which point-of-care testing (POCT) has been found to ameliorate factors thought to contribute to overcrowding; and (c) to discuss how POCT can be used directly, and indirectly, to expedite patient care and improve outcomes. Various studies have shown that overcrowding in the ED has profound effects on operational efficiency and patient care. Several reports have quantified overcrowding in the ED and have described a relationship between heightened periods of overcrowding and delays in treatment, increased incidence of adverse events, and an even greater probability of mortality. In certain scenarios, POCT has been found to increase the number of patients discharged in a timely manner, expedite triage of urgent but non-emergency patients, and decrease delays to treatment initiation. This review concludes that POCT, when used effectively, may alleviate the negative impacts of overcrowding on the safety, effectiveness, and person-centeredness of care in the ED.
A novel phosphatidylinositol 3-kinase (PI3K) inhibitor directs a potent FOXO-dependent, p53-independent cell cycle arrest phenotype characterized by the differential induction of a subset of FOXO-regulated genes
Authors: Hill Richard , Kalathur Ravi Kiran Reddy , Callejas Sergio , Colaço Laura , Brandão Ricardo , Serelde Beatriz , Cebriá Antonio , Blanco-Aparicio Carmen , Pastor Joaquín , Futschik Matthias , Dopazo Ana , Link Wolfgang
Published: December 2014

Introduction

The activation of the phosphoinositide 3-kinase (PI3K)/AKT signalling pathway is one the most frequent genetic events in breast cancer, consequently the development of PI3K inhibitors has attracted much attention. Here we evaluate the effect of PI3K inhibition on global gene expression in breast cancer cells.

Methods

We used a range of methodologies that include in silico compound analysis, in vitro kinase assays, cell invasion assays, proliferation assays, genome-wide transcription studies (Agilent Technologies full genome arrays), gene set enrichment analysis, quantitative real-time PCR, immunoblotting in addition to chromatin immunoprecipitation.

Results

We defined the physico-chemical and the biological properties of ETP-45658, a novel potent PI3K inhibitor. We demonstrated that ETP-45658 potently inhibited cell proliferation within a broad range of human cancer cells, most potently suppressing the growth of breast cancer cells via inhibiting cell cycle. We show that this response is Forkhead box O (FOXO) protein dependent and p53 independent. Our genome-wide microarray analysis revealed that the cell cycle was the most affected biological process after exposure to ETP-45658 (or our control PI3K inhibitor PI-103), that despite the multiple transcription factors that are regulated by the PI3K/AKT signalling cascade, only the binding sites for FOXO transcription factors were significantly enriched and only a subset of all FOXO-dependent genes were induced. This disparity in gene transcription was not due to differential FOXO promoter recruitment.

Conclusions

The constitutive activation of PI3Ks and thus the exclusion of FOXO transcription factors from the nucleus is a key feature of breast cancer. Our results presented here highlight that PI3K inhibition activates specific FOXO-dependent genes that mediate cell cycle arrest in breast cancer cells.
Quality of Service in Public Transport Based on Customer Satisfaction Surveys: A Review and Assessment of Methodological Approaches
Authors: de Oña Juan , de Oña Rocio
Published: December 2014

The growth of literature in the field of quality of service in the public transport (PT) sector shows increasing concern for a better understanding of the factors affecting service quality (SQ) in PT organizations and companies. A large variety of approaches to SQ have been developed in recent years owing to the complexity of the concept; the broad range of attributes required to evaluate SQ; and the imprecision, subjectivity, and heterogeneous nature of the data used to analyze it. Most of these approaches are based on customer satisfaction surveys. This paper seeks to summarize the evolution of research and current thinking as it relates to the different methodological approaches for SQ evaluation in the PT sector over the years and to provide a discussion of future directions.
Struggling with change: The predicament of evolution and change for religious traditions
Authors: Henriksen Jan-Olav
Published: December 2014

The present article identifies and reflects on some dimensions in how change is a vital and necessary (constitutive) element in the development of religious traditions. Change both challenges and contributes to the upholding of these traditions. The argument is that contrary to popular opinion, change should not be seen as a problem for religion, but as an important condition for religion, even when it comes to the very basic biological conditions of humanity that make possible the historical and cultural realms of our existence – realms in which religion mainly expresses itself. Thus, it offers reasons for taking leave of the idea that religions are, or should be, expressions of an unchanging world order and of unchanging normative doctrinal positions. Such a position does not take historical change seriously, but it also ignores the basic evolutionary conditions of religion, as well as the pragmatic and adaptive features in religion. Thus, the constructive argument of the article is to propose that change and order work in interplay and that they are mutually dependent or dialectically related to each other. Religion must be seen as existing in the tension between order and contingency, stability and dynamics, law-like regularities and change. Religion would accordingly, from this perspective, be just as much about change as about that which endures and remains unchanging.