bluuebunny/crossref_metadata_2025 huggingface dataset:
PROYECTOSAPP: SISTEMA WEB PARA LA GESTIÓN DE REPOSITORIO DIGITAL DE PROYECTOS DE INVESTIGACIÓN DE LA UNIVERSIDAD DE SAN BUENAVENTURA
Authors: Mesa Calderon Oscar David , Mora Rueda Haydin Neleb Natalia , Sánchez Martín Andrés Armando , Barreto Santamaría Luis Eduardo
Published: September 2020

En la Universidad de San Buenaventura, no existe un sistema que muestre, organice y preserve los diferentes tipos de trabajos y proyectos presentados por estudiantes y/o profesores en los comités y materias de los programas académicos, lo cual conlleva a una gran cantidad de proyectos que no avanzan significativamente. por otro lado, los estudiantes no tienen acceso a proyectos viables o en desarrollo, que se encuentran inactivos o en proceso de ejecución para poder integrarse a ellos o darles continuidad. Para solucionar dichos problemas, se debe crear un sistema para la gestión de proyectos de investigaciones en la universidad. El objetivo de este estudio es implementar un repositorio web para dar visibilidad y gestión de las investigaciones desarrolladas en la universidad San Buenaventura sede Bogotá. Teniendo esto en cuenta, surge la pregunta: ¿Cómo hacer visible y gestionar la investigación aplicada y científica de la universidad San Buenaventura-Sede Bogotá? El proyecto se desarrollará, utilizando eXtreme Programming (XP) y la metodología base de ingeniería que está constituida por cuatro fases: análisis, diseño, implementación y validación. Cada fase poseerá una serie de actividades que responden al cumplimiento del objetivo, así como un límite de tiempo para cada actividad.  Como resultado de este proyecto, actualmente se desarrollaron diagramas de procesos bajo el estándar BPMN, los requerimientos funcionales y no funcionales, y diagrama de casos de uso en UML los cuales describen el desarrollo de proyectos en la Universidad de San Buenaventura.
UNA REVISIÓN SISTEMÁTICA SOBRE CONCURSOS ACADÉMICOS COMO UNA HERRAMIENTA DIDÁCTICA
Authors: Forero Forero Jimmy Giovanny , Chappe Chappe Angélica , Martínez Rojas Luisa Fernanda
Published: September 2020

Este trabajo pretende identificar cómo los concursos académicos desarrollan y fortalecen las habilidades matemáticas de los estudiantes y además son un recurso didáctico que potencian el talento de jóvenes interesados por las matemáticas. En consecuencia, se utilizará el método de revisión sistemática de tipo teórico para seleccionar y estudiar la bibliografía y así recopilar la información relevante acerca de la implementación de concursos académicos en educación superior entre los años 2008 y 2018. Puesto que el Encuentro Universitario de Integrales es un escenario de competición que promueve entre sus competidores la capacidad de síntesis, la creatividad, la facilidad en la comunicación y el desarrollo del pensamiento crítico, entre otras habilidades, este se convierte en una oportunidad que busca motivar el interés en los estudiantes para trabajar las matemáticas en un ambiente diferente al salón de clases.
EVALUACIÓN DE LA TRANSFORMACIÓN DE AGUAS RESIDUALES EN PRODUCTOS DE VALOR AGREGADO: PRODUCCIÓN DE POLIHYDROXYALKANOATES (PHAS)
Authors: Gracia Jeniffer , Mosquera Jhessica , Montenegro Carlos , Suarez Luisa , Acevedo Paola , Cabeza Iván
Published: September 2020

Los procesos de bioconversión se presentan como una oportunidad para alcanzar la sostenibilidad ambiental, teniendo como pilar principal la producción de combustibles, sustancias químicas y materiales de base biológica; los cuales pueden resultar del aprovechamiento de residuos. En esta búsqueda, se encontró que los lodos de plantas de tratamiento de aguas residuales (PTAR) constituyen un residuo altamente contaminante para el cual se requiere implementar alternativas de valorización. Entre las tecnologías aplicables, se encuentra la producción de polímeros biodegradables del tipo polihidroxialcanoatos (PHA), los cuales se pueden obtener a partir de cultivos microbianos mixtos que aprovechan líquidos fermentados ricos en ácidos grasos volátiles (AGVs). Por consiguiente, uno de los objetivos de este proyecto es encontrar las mejores condiciones para la producción de AGVs, que permitan el uso de lodos provenientes de la PTAR EL SALITRE en procesos futuros de generación de PHAs. Durante el desarrollo de la fase inicial del proyecto, se evaluaron diferentes condiciones operativas que afectan la producción de AGVs, como: carga orgánica, con niveles de 4 a 6 g SV L-1 y pH alcalino, entre 9.5 y 11.5. Los resultados obtenidos permitieron evidencias que lodos evaluados permiten obtener altas cargas de AGVs entre 1063 y 1300 AGV L-1; en consecuencia, el líquido fermentado obtenido puede ser utilizado como fuente de carbono para la producción de PHAs.
DISEÑO Y APLICACIÓN DE UN PROGRAMA DE INTERVENCIÓN EN SEGURIDAD Y SALUD EN EL TRABAJO, BASADO EN LOS FACTORES DE RIESGOS LABORALES, EN SALONES DE BELLEZA / PELUQUERÍAS DE LA AVENIDA GUAIMARAL DE CÚCUTA 2019
Authors: Carvajal Villamizar Henny Patricia , Clavijo Olarte Lilian Edith
Published: September 2020

El presente trabajo de investigación tiene como objetivo principal, Diseñar y aplicar un programa de intervención, en seguridad y salud en el trabajo, en población en servicio de estética/cosmética ornamental de la avenida Guaimaral de Cúcuta 2019. Se toma esta población teniendo en cuenta el estudio sobre la informalidad empresarial en el municipio de Cúcuta y su área de influencia 2013 y 2017, ya que constituye una fuente de absorción de mano de obra desprotegida y con accesos limitados en seguridad y salud en el trabajo.

Se realizará un estudio descriptivo de corte transversal, Se llevara a cabo en 10 salones de belleza ubicados en la avenida Guaimaral de Cúcuta realizando un muestreo por conveniencia, para le recolección de datos se hará uso de dos instrumentos el primero se aplicará II Encuesta Nacional de Condiciones de Seguridad y Salud en el Trabajo, posteriormente se aplicara la Matriz de peligros basados en la GTC 45 y listas de Chequeo (Condiciones Locativas y Bioseguridad), para la identificación de los peligros y la valoración de los riesgos a los cuales están expuestos los trabajadores. Culminado el proceso de recolección de datos se busca intervenir a la población por medio de estrategias desde Seguridad y Salud.
Assessing cytokine status of patients with chronic endometritis combined with endometrial hyperplastic processes in reproductive period
Authors: Tkachenko L. V. , Sviridova N. I. , Zharkin N. A. , Burova N. A. , Belan E. B.
Published: September 2020

The goal of our study was to examine local and serum cytokine level involved in regulating inflammation in patients with chronic endometritis combined with endometrial hyperplastic processes. On admission, all patients underwent hysteroscopy with separate diagnostic curettage followed by histological examination of samples isolated from the uterine and cervical canal mucosa. Such manipulations were indicated due to abnormal uterine bleeding as well as suspected endometrial pathology based on ultrasound examination. According to the histological examination data of the endometrial samples, all patients were divided into two groups: group I contained 45 women with CE combined with PEG without atypia; group II — 38 patients with morphologically verified CEE combined with AEG without atypia. Level of IL-1P, IL-2, IL-6, IFNy, TNFa in biological fluids (aspirate from the uterus; serum) was measured by using enzyme-linked immunosorbent assay. We found that in both groups (91.1% and 89.6%, respectively) the vast majority of patients was hospitalized due to abnormal uterine bleeding. Oligomenorrhea alternated with intermenstrual bleeding (66.7% and 71.2%, respectively) and dominated in pattern of menstrual cycle disorders in the examined patients, whereas 11 (24.4%) and 7 (18.4%) patients from group I and II, respectively, were noted to suffer from severe menstrual bleeding. Overall, analyzing the data on cytokine level both in the uterine aspirate and serum evidences about ongoing inflammatory process found at examination time point. Upon that, such process was not only local, but also exhibited signs of a systemic inflammatory response. The data on cytokine level in the uterine aspirate from patients with CE coupled to PGE or CGE without atypia point at local inflammatory process characterized by significantly increased concentration of IL-ф, IL-2, IL-6, TNFa and IFNy. At the same time, higher level of IL-ф and IFNy in patients from group II might indicates that degree of morphological changes in the endometrium could affect the level of local cytokine production. Thus, the data obtained evidence that immune changes in chronic endometritis combined with non-atypical endometrial hyperplastic processes mostly occur locally. In this regard, measuring cytokine concentration in the uterine aspirate is a diagnostic predictor and serves as a sign for monitoring therapeutic effectiveness of therapy in this cohort of patients.
Functional activity of peripheral blood monocytes in patients with opisthorchiasis coupled to liver fibrosis intensity
Authors: Tsukanov V. V. , Gorchilova E. G. , Kolenchukova O. A. , Gvozdev I. I. , Savchenko A. A. , Vasyutin A. V. , Tonkikh J. L. , Rzhavicheva O. S. , Borisov A. G.
Published: September 2020

The aim is to examine activity of peripheral blood monocytes from patients with opisthorchiasis coupled to intensity of liver fibrosis. Materials and Methods. A total of 74 patients with chronic opisthorchiasis (39 males and 35 females, average age 42.3 years) and 32 apparently healthy subjects (17 males and 15 females, average age 41.5 years) aged 24 to 60 years were enrolled. Opisthorchiasis was mainly diagnosed by parasitological assays to detect adult parasite eggs or bodies in duodenal contents and/or feces in all 74 patients. Liver fibrosis was assessed by elastometry according to the METAVIR scale. Functional activity of peripheral blood monocytes was performed in all patients with opisthorchiasis and healthy individuals from the control group by chemiluminescent analysis to measure intensity of reactive oxygen species production in lucigenin- and luminol-dependent spontaneous and zymosan-induced reactions. Results. Liver fibrosis F2 and F3—F4 stage according to METAVIR scale was found in 20.3% and 17.6% of patients with opisthorchiasis, respectively. While analyzing total pool of reactive oxygen species in the luminol-dependent process in patients with opisthorchiasis, a significantly decreased monocyte functional activity was observed as compared to healthy subjects that was evidenced by significantly decreased maximum intensity of produced reactive oxygen species as well as area under the chemiluminescence curve both in spontaneous and zymosan-induced reaction. Such parameters in liver fibrosis F3—F4 compared to F0—F1 in zymosan-induced response were lowered. Monocyte functional activity in spontaneous luminol-dependent reaction did not differ significantly depending on liver fibrosis intensity in patients with opisthorchiasis. The phagocytosis activation index in patients with opisthorchiasis with liver fibrosis F3—F4 compared to F0—F1 and F2 stage was lower. Similar changes were observed in the lucigenin-dependent reaction. Conclusion. The data obtained undoubtedly provide promising evidence to interpret the mechanisms behind liver fibrosis in patients with opisthorchiasis and create new opportunities for development of diagnostic and therapeutic technologies.
Immunoglobulins and predicted mortality in clinical course of concomitant HIV and TB infection
Authors: Mal’tseva N. V. , Victorova I. B. , Kazantseva O. M. , Arkhipova S. V. , Khanin A. L.
Published: September 2020

A search for prognostic markers of HIV and tuberculosis coinfection (HIV/TB), especially in case of Mycobacterium tuberculosis multidrug resistance (MDR MBT) associated with low rates of TB eradication, is of relevance in connection with the problem of choosing adequate anti-TB therapy which is able to decrease mortality. 113 HIV/TB patients aged 24 to 58 years were examined: 70 males and 43 females hospitalized at the Novokuznetsk TB Clinic during the 2017—2019 period. MDR MBT (concomitant resistance to Isoniazid and Rifampicin) was found in 50 patients (12 patients with MDR MBT had additional resistance to Fluoroquinolones) aged 24 to 54 years — 31 males and 19 females. The control group consisted of 49 healthy individuals aged 27 to 72 years (26 females and 23 males) lacking focal and systemic infections with moderately pronounced age-related changes. In plasma samples, concentration of total (non-specific) immunoglobulins of classes E, M, G, A (including secretory immunoglobulin A, sIgA) were measured by using enzyme-linked immunosorbent assay. Data statistical processing was performed by using licensed software packages InStatII, Microsoft Excel, IBM SPSS Statistics 22. An extended range of individual variability in count of peripheral blood CD4 lymphocytes was revealed both among non-survivor and survivor patients with HIV/TB examined, being a drawback of using such parameter as lethality predictor. It was found that the serum level of total IgE, IgM, IgG, IgA and sIgA in patients with HIV/ TB was higher than that one in control group, whereas in non-survivor vs. survivor patients the concentration of IgE and sIgA was elevated. The coefficient of disease outcome prediction (CP) for patients with HIV/TB and MDR MBT was calculated being equal to the ratio of the multiplication of serum concentration of IgE, IgM, IgA and secretory IgA to CD4 lymphocyte count (CP = IgE x IgM x IgA x sIgA/CD4). CP higher than 200 was detected in 77% non-survivor and 6% of survivor patients. The relative risk of death with CP 200 was very high (OR = 56.7, p 0.0001) being 8.5 times higher than that one upon CD4 200 (OR = 6.7, p = 0.0237). A positive correlation between CP and lethal outcome was more valuable than that of CD4. The data presented allow us to propose CP for clinical use as an effective prognostic criterion for HIV/TB with MDR MBT.
Clinical and immunological characteristics of bacterial pneumonia associated with HIV infection coupled to drug addiction
Authors: Puzyreva L. V. , Mordyk A. V. , Paneva M. A.
Published: September 2020

Bacterial pneumonia holds the second place after respiratory tuberculosis in patients with HIV infection. In recent years, sexual transmission of HIV was replaced by injection drug route. It seems of high relevance to advance medical aid to patients with HIV infection and bacterial pneumonia depending on psychoactive substance use.Aim of study — assessment of clinical and immunological manifestations of bacterial pneumonia coupled to HIV infection with respect to verified injection drug use.Materials and methods. Clinical and immunological data collected from 224 patients with HIV infection and pneumonia were retrospectively analyzed: group 1 group — 70 patients with HIV infection, IDU, verified bacterial pneumonia; group 2 — 16 injecting drug users (IDU) with HIV infection and pneumonia of unverified etiology; group 3 — 65 patients with HIV and bacterial pneumonia of verified etiology without injection drug use, group 4 — 73 patients with HIV infection and bacterial pneumonia of unverified etiology, without injection drug use. The data obtained were analyzed by using software Statistica 13.3. Methods of descriptive statistics with calculation of nonparametric criterion — the Kruskall—Wallis test (H-criterion) and χ2 test — were used.Results. Immunological manifestations of HIV infection and bacterial pneumonia were characterized by decreased count of CD4+ cells paralleled with increased count of CD3+ and CD8+ cells at higher magnitude without injection drug use being also featured with peak viral load upon developing pneumonia. Bacterial pneumonia coupled to HIV infection showed clinical manifestations similar both in injecting drug users and non-users, proceeding in 10% cases during normothermia. Injection drug user patients often demonstrated clinical picture of pneumonia resembling those found in sepsis such as pain in the body, muscles, bone aches untypical to HIV-sexually infected subjects. In addition, systolic murmur on a heart top was more often auscultated in this patient group.Conclusion. Subjects self-considered healthy being at risk of sexually transmitted infections should examined for HIV. All subjects manifested with symptoms of the lower airway tract infections in admission department should not be rejected to be hospitalized and undergo chest X-ray examination.
Molecular genetic characteristics of the carbapenem resistant Klebsiella pneumoniae KP254 strain as a representative of the highly virulent strain evolutionary branch
Authors: Alekseeva A. E. , Brusnigina N. F. , Gordinskaya N. A.
Published: September 2020

Here we provide molecular and genetic characteristics of the Klebsiella pneumoniae KP254 clinical strain belonging to clonal group 23 based on the genome-wide sequencing data. It is known that representatives of such clonal group exert highly virulent properties and cause community-acquired infections. Phenotypically, K. pneumoniae KP254 strain is characterized by multidrug resistance, including carbapenems. The determinants of antibiotic resistance (blaSHV-1, oqxAB, fosA) and pathogenicity encoding fimbriae 1, 3 types and the siderophore yersineobactin synthesis were found in the chromosome structure. However, there was uncovered the lack of conjugative element ICEKp1, the pathogenicity island KPHPI208, and the allantoin regulon genes which are often found in highly virulent strains. Analyzing nucleotide sequences in silico allowed to reveal the replicons of incompatibility group plasmids for FII, FIAHI1/FIIK, Col440I, ColpVC, FIBK, FIIpCRY. Combining contigs relative to reference sequences by using the BLASTN service allowed to identify two putative antibiotic resistance plasmids IncFII and IncFIIpCRY as well as one virulence plasmid IncFIBK. The determinants of the aerobactin siderophore, the RmpA2 mucoid phenotype regulator as well as heavy metal resistance genes constitute the virulence plasmid structure. The virulence plasmid nucleotide sequence coverage comprised 93% relative to the virulence plasmid pK2044 with 99.38% identity level; the genomic regions responsible for the salmochelin and RmpA protein synthesis were deleted. The set of antibiotic resistance determinants identified in the mobilome structure includes the genes for beta-lactamase LAP-2 (IncFIIpCRY plasmid) — a TEM-1 analogue, as well as extended-spectrum beta-lactamase CTX-M-55 (IncFII plasmid), both of which are rarely recorded in the Russian Federation. Additionally, widespread genes blaOXA-1, aac(3’)-IIa, ΔcatB4, aac (6’)-Ib-cr, tet(A), qnrSI, sul2, catA2 were also found in the plasmid DNA. The carbapenemase genes are absent in the resistome structure, whereas the examined strain exerts carbapenem resistance. The analysis of the ompK35 and ompK36 porin gene translated sequences revealed mutational changes which resulted in emerged stop codon within the ompK35 gene, whereas OmpK36 amino acid sequence contains a large number of substitutions, insertions, and deletions. The changes identified serve as one of the factors determining the carbapenem resistance. A synergistic effect may be accounted for by activity of the efflux pumps found in the structure of the K. pneumoniae KP254 genome, particularly AcrAB-TolC and KpnEF. Thus, the strain examined by us preserves the most significant signs specific to the highly virulent evolutionary branch Klebsiella strains, and at the same time, acquires the multidrug resistance genetic determinants.
Bioinformatics analysis of putative causes for сross-reactive antibodies interacting with antigens derived from various pathogenic human papillomaviruses
Authors: Stolbikov A. S. , Salyaev R. K. , Rekoslavskaya N. I.
Published: September 2020

Human papillomaviruses (HPVs) belong to highly abundant resulting in sexually transmitted virus infections, and cause cervical cancer holding place 4 among most common cancer types in women. In 2012, there were registered 266,000 death cases and 528,000 new cases. At present, three HPV prophylactic vaccines were generated worldwide: bivalent Cervarix, quadrivalent Gardasil and nonavalent Gardasil-9. Examining such vaccines uncovered that they are able to induce anti-HPV antibody production against viral antigens lacked in vaccine formula. The mechanism of such crossneutralizing antibodies recognizing antigens derived from various HPV pathogenic types remains unknown. In our study we attempted to uncover putative basis underlying cross-reactive interaction between vaccine-induced antibodies and non-vaccine antigens by bioinformatical approaches, that might allow optimize generation of future candidate vaccines and obtain more effective polyvalent immunobiological preparations against HPV. We used amino acid sequences of L1 coat protein of four top high-risk oncogenic HPV types (16, 18, 31 and 45) in the study. Work sequences were retrieved from the International Data Base of NCBI (National Center for Biotechnology Information) and aligned by using Clustal Omega’ and BioEdit software. A search and analysis of distinct antigenic determinant (epitopes) were performed by using software suite BepiPred-2.0: Sequential B-Cell Epitope Predictor, DiscoTope 2.0 Server, and SYFPEITHI. Bioinformatics data revealed pronounced potential of cross-neutralizing vaccine-induced antibodies and non-vaccines antigens derived from high-risk pathogenic types HPV 16, 18, 31 and 45 owing to the similarity in antigenic determinants (epitopes). Common linear determinants for T- and B-cells were found in all four types of L1 protein counterparts. In addition, similar three-dimensional B-cell determinants were discovered in HPV16 L1 and HPV18 L1. Antigenic determinants derived from HPV16 L1 and HPV31 L1 exhibited most close similarity. Hence, while immunizing with HPV16 L1, a more pronounced and moderate cross-reactive antibodies interacting with HPV31 L1 as well as HPV18 L1 and HPV45 L1 antigens, respectively, should be expected. Inversely, immunization with HPV18 L1might elicit active and less efficient crossneutralizing response with HPV45 L1 as well as HPV16 L1 and HPV31 L1, respectively.
Altered interferon defense in children with dynamically changed infectious mononucleosis
Authors: Kukushkina E. A. , Koteleva S. I. , Blyakher M. S. , Fedorova I. M. , Ramazanova Z. K. , Zvereva N. N. , Novosad E. V. , Samkov A. A. , Bazarova M. V.
Published: September 2020

The state of the interferon system in 38 children with acute infectious mononucleosis (IM) caused by the Epstein—Barr virus was analyzed. Interferon status was examined in accordance with F.I. Ershov method based on assessing related biological activity by measuring interferon level in the blood serum or produced by blood cells. The aim of the study was to gain scientifically justified data for use of interferon preparations or interferonogens in IM combination therapy. For this, interferon status in children with acute IM was compared with that one not only in control group (30 healthy children, aged 3—6 and 20 children, aged 7—14 years, examined earlier to create an intra-laboratory interferon normal range), but also in children with lacunar angina or acute respiratory viral infection, hospitalized in the same department of the clinic and comparable with the main group in severity of the condition. In addition, we assessed changes in IFN-status in IM patients receiving no interferon preparations, one month after the disease onset. The study showed that patients with moderate acute IM were featured with decreased potential of blood leukocytes to virus-induced IFNa and mitogen-induced IFNy production observed with almost similar or some lower rate as in the control group of children hospitalized with angina or acute respiratory viral infection. Peripheral blood cells from moderate acute IM patients in the 3-6-year age group were found to produce virtually unaltered interferon level, whereas almost sole IFN-alpha production was affected in 7-14-year-old patients. Moreover, in 7-14-year old patients the level 1 and level 2 of IFNa deficiency was observed in 38% and 6% of cases, respectively. It is likely it was just this patient group requiring administration of any IFNa replacement therapy. As few as 12 children were re-examined after discharge from the clinic. Initially, prevalence and severity level of impaired interferon production in this subgroup did not differ from that one for total patient sample, whereas 1 month later a host potential to produce both IFNa and IFNy even without therapy acting on interferon system was noted to be moderately augmented.
State of lipid peroxidation and antioxidant defense in chronic gastritis associated with Helicobacter pylori-infection in middle-aged males
Authors: Smirnova O. V. , Sinyakov A. A. , Titova N. M.
Published: September 2020

Helicobacter pylori is the most widespread human pathogen, with prevalence reaching up to 20—40% and 80— 90% of adult infection in developed and developing countries, respectively. Many authors consider this infection as a major factor in the development of gastric cancer. In case of H. pylori infection, free homogeneous oxidation is augmented, that elevates the blood amount of POL products. Hyperproduction of reactive oxygen species stimulates free radical POL, accompanied by membrane destruction, damage to proteins, lipids, and DNA. Thus, the destruction of the intracellular and cell outer membranes occurs resulting in cell death. In diseases associated with H. pylori infection, there is a dysregulation of the lipid peroxidation system — antioxidant defense contributing to inconsistency in the regeneration phases triggering disease progression. The aim of our work was to study indicators of POL (diene conjugates, malonic dialdehyde) and antioxidant protection (AOP) (superoxide dismutase enzymes, catalase) in chronic gastritis and chronic atrophic gastritis associated with H. pylori infection. In patients with CG associated with H. pylori as well as CAG and CAG associated with H. pylori they were featured with increased amount of primary (↑DC) and end TBA-active products of lipid peroxidation (↑MDA), whereas activity of superoxide dismutase was decreased, additionally highlighted with reduced catalase activity (↑CAT) in CAG and CAG associated with H. pylori. H. pylori just triggers the mechanisms of ROS generation in host cells. The energy of redox reactions is used by the microorganism to carry out its physiological functions and serves as a factor in its own pathogenicity, the ROS generated in such reactions can have a damaging effect on the structure of gastric mucosa. In addition, examining H. pylori genome has shown that it bears the genes encoding oxidative metabolism enzymes, such as SOD, catalase, nitroreductase, flavodoxin oxidoreductase. Long-term persistence of H. pylori in the gastric mucosa paralleled with its increased biomass accounts for it being the main source of ROS production able to augment lipid peroxidation and cause damage to the membrane structures and DNA of gastric epithelium cells.
A OPINIÃO PÚBLICA NAS DEMOCRACIAS ESPETACULARES CONEXÕES (IM)PERTINENTES DA GOVERNAMENTALIDADE BIOPOLÍTICA DE FOUCAULT E OS DISPOSITIVOS ACLAMATÓRIOS DA SOBERANIA EM AGAMBEN*
Authors: Ruiz Castor M.M. Bartolomé
Published: September 2020

RESUMO O presente ensaio apresenta uma análise crítica das atuais democracias que se esvaziaram do poder deliberativo do demos para se tornarem, cada vez mais, democracias espetaculares. Inicialmente, seguindo os estudos de Foucault, analisam-se as implicações da governamentalidade sobre a democracia, principalmente a partir da emergência da opinião pública como técnica da razão de Estado. Posteriormente, relacionam-se os estudos de Foucault com as teses de Agamben a respeito da burocracia e a hierarquia, a fim de compreendermos como estas pesquisas desembocam no conceito de democracias espetaculares defendido por Agamben.
THOUGHT IN THE SERVICE OF INTUITION: HEIDEGGER’S APPROPRIATION OF KANT’S SYNTHETIC A PRIORI IN DIE FRAGE NACH DEM DING
Authors: Crichton Cristina
Published: September 2020

ABSTRACT There is general agreement that Kant’s thought strongly influenced Heidegger’s. Nevertheless, there is still much work to be done in order to fully appreciate this influence. A central theme to disclose the relation between these authors is the role they give to the transcendental. In this paper I show that Kant’s account of intuition is the focus of Heidegger’s interpretation of Kant in his Die Frage nach dem Ding, since Heidegger interprets Kant’s treatment of intuition as a delimiting of the modern mathematical tendency to determine everything out of pure reason alone. I argue that this interpretation is at the basis of Heidegger’s appropriation of Kant’s synthetic a priori in this work, the aim of which is to take this notion away from the sphere of the objects of mathematical physical science, and place it in the realm of everyday experience. I claim that Heidegger thinks that this move can only be accomplished by removing universality and necessity (epistemic certainty) from Kant’s a priori. Finally, I show that Heidegger’s appropriation of Kant’s synthetic a priori goes together with and illuminates his understanding of transcendence as das Zwischen, ‘the between us and things’.
O PROBLEMA DA EXTENSÃO DO CONHECIMENTO NA HIPÓTESE REGULACIONISTA DA ILUMINAÇÃO EM AGOSTINHO DE HIPONA
Authors: Costa Daniel Rodrigues da
Published: September 2020

RESUMO O objetivo deste artigo é analisar o problema da extensão e do conteúdo da iluminação uma vez que se adote a interpretação regulacionista para a teoria do conhecimento de Agostinho. O regulacionismo, tese defendida por Etienne Gilson, afirma que a iluminação divina do intelecto humano diz respeito ao caráter necessário dos conhecimentos alcançados pela inteligência, e não sobre o conteúdo do conhecimento; assim, a iluminação não teria por função auxiliar na formação de conceitos, mas teria a função de julgar a adequação desses conceitos à verdade. Entretanto, interpretações desse tipo trazem um problema quanto à autonomia cognitiva humana, já que o intelecto seria constrangido externamente em relação ao seu conhecimento. Trataremos, ainda, da crítica sobre a exagerada ênfase na epistemologia que a hipótese regulacionista reverbera. Por fim, e de acordo com o regulacionismo, buscaremos dar uma resposta coerente ao problema da extensão do conhecimento oriundo da iluminação, respeitando tanto a singularidade do raciocínio humano quanto a primazia do conhecimento divino.
CLAUDE BERNARD, BERGSON E O CONHECIMENTO DA VIDA COMO PROBLEMA
Authors: Teixeira Rafael Henrique
Published: September 2020

RESUMO O objetivo deste artigo é apresentar, tomando por referência a filosofia de Henri Bergson (1859-1941) e a fisiologia experimental de Claude Bernard (1813-1878), dois esforços análogos, ainda que sem relação direta em suas origens, em face de imperativos que se colocam ao sujeito do conhecimento que se ocupa da vida. Tentaremos mostrar, autorizados pelo próprio Bergson, no interior de determinada prática científica representada pela fisiologia experimental de Claude Bernard, uma atitude diante dos fatos orgânicos que não é o monopólio de uma filosofia que se ocupa da verificação das condições e dos limites do conhecimento da vida, problemática que, na filosofia francesa do século XX, encontra em L’Évolution créatrice (1907) uma expressão incontornável.
WHY DO WE NEED THE NOTION OF WILL?
Authors: Vogelmann Rafael Graebin
Published: September 2020

ABSTRACT It is commonly held that the goals at which an action aims are specified by the pro-attitude/belief pairs in light of which the action seems appealing to the agent. I argue that the existence of multiple-incentives cases (i.e., cases in which the agent has more than one incentive to act but in which her motive corresponds to only one of these incentives) shows this thesis to be false. In order to account for such cases we have to ascribe to agents the capacity to actively determine the goals at which their actions aim. I refer to this capacity as the agent’s “will”. Agents endowed with a will are capable not only of determining their own behavior but also their motives. I conclude that the existence of multiple-incentives cases shows that agents have this capacity.
Cárie dentária e fatores associados aos 12 anos na Região Centro-Oeste do Brasil em 2010: um estudo transversal
Authors: Silva Hellen Carla Alves da , Espinosa Mariano Martínez , Moi Gisele Pedroso , Ferreira Márcia Gonçalves
Published: September 2020

Resumo O objetivo do estudo é analisar o índice de dentes cariados, perdidos e obturados (CPO-D) na idade de 12 anos da Região Centro-Oeste e identificar fatores associados, segundo a Pesquisa Nacional de Saúde Bucal, o SB Brasil 2010. É um estudo transversal de base populacional do banco de dados do SB Brasil 2010, realizado nas capitais de Mato Grosso, Mato Grosso do Sul, Goiás, Distrito Federal e uma amostra de municípios da região. Os dados foram analisados pelo teste de qui-quadrado e razões de prevalências com seus respectivos intervalos de confiança, a um nível de significância de 0,05. A regressão de Poisson foi empregada na análise múltipla para analisar a associação entre a variável desfecho e as variáveis explicativas. As variáveis independentes que se mostraram associadas ao CPO-D foram: o estado de moradia em Mato Grosso, Goiás e Mato Grosso do Sul; a renda per capita ≤ R$500,00; dificuldade para comer e dormir, e o motivo da consulta por Dor/Extração/Tratamento/Outros. A média do índice CPO-D foi de 2,14 e a prevalência da cárie dental foi de 41% dos adolescentes.
Fatores de postergação da aposentadoria de idosos: revisão integrativa da literatura
Authors: Souza Laudiane Barros Correia de , Leal Márcia Carréra Campos , Bezerra Adriana Falangola Benjamin , Silva Isabella Caline de Lima , Souza Leandro Correia Gonçalves de , Santo Antônio Carlos Gomes do Espírito
Published: September 2020

Resumo O presente estudo objetivou a busca de evidências científicas publicadas em estudos analíticos que versam sobre fatores de postergação da aposentadoria de trabalhadores idosos. Foi realizada uma revisão integrativa da literatura com busca de artigos originais nas bases da Biblioteca Virtual de Saúde e SciELO no período de janeiro/2009 a março/2018. Foram selecionados 12 artigos após consenso de revisores independentes gerando duas categorias: Literatura Nacional e Literatura Internacional. Tal escolha foi porque o fenômeno do envelhecimento populacional acarreta impactos sociais e econômicos diferentes entre as nações desenvolvidas e naquelas em desenvolvimento, como o Brasil. Na análise dos resultados encontramos que a decisão de aposentadoria dos idosos envolve uma variedade de fatores pessoais, organizacionais e outros (legislativos, culturais, sociopolíticos e tecnológicos). Em conclusão constatamos a escassez de estudos na temática com amostras exclusivasde idosos em ambas as categorias, assim como a maior ou menor relevância de determinado fator dependerá do contexto de vida de cada trabalhador. Além do mais, como a decisão de aposentadoria é um processo dinâmico, existe carência de estudos longitudinais que necessitam ser supridos com pesquisas mais robustas nacionais da população idosa.
Cuidados em saúde bucal a crianças e adolescentes com paralisia cerebral: percepção de pais e cuidadores
Authors: Silva Elizabeth Louisy Marques Soares da , Góes Paulo Sávio Angeiras de , Vasconcelos Márcia Maria Vendiciano Barbosa , Jamelli Silvia Regina , Eickmann Sophie Helena , Melo Márcia Maria Dantas Cabral de , Lima Marília de Carvalho
Published: September 2020

Resumo Objetivou-se avaliar os cuidados em saúde bucal de crianças/adolescentes com Paralisia Cerebral (PC) segundo a gravidade, através da percepção dos pais/cuidadores. Estudo série de casos realizado em serviços de saúde de Pernambuco com 94 mães/cuidadores de sujeitos com PC entre 5 e 18 anos. Avaliaram-se fatores socioeconômicos, demográficos, cuidados em saúde bucal e uso de serviços odontológicos (SO). O Sistema de Classificação da Função Motora Grossa mostrou 67% com comprometimento motor grave. Indivíduos com PC grave tiveram frequência significantemente maior de pertencerem a famílias com renda mais baixa (89%, p < 0,001), residirem no interior (44%, p < 0,005), terem dificuldades de transporte (60%, p = 0,04) e acessibilidade aos SO (88%, p = 0,009) e maior necessidade de higiene bucal (67%, p = 0,008) realizada pelas mães (94%, p < 0,001). Apesar das barreiras de acesso aos SO, o mesmo foi facilitado para aqueles com PC grave, com uso precoce dos SO, mas com baixa oferta de dentistas e de humanização. Esses resultados informam problemas relacionados aos cuidados diários em saúde bucal, contexto de vida das famílias, de apoio institucional e de qualidade dos SO a serem enfrentados com políticas públicas socioeconômicas e de saúde integrais inclusivas e equânimes.
Avaliação do potencial quimioprotetor do fruto de Psidium guajava contra os efeitos genotóxicos da doxorrubicina
Authors: Almeida Junior Silvio de , Branquinho Gabriel Nalini , Santos Lidiane Andrade Silva , Silva Lucas Henrique Domingos da , Cruz Roberta Cristina Ribeiro , Dias Fernanda Gosuen Gonçalves , Furtado Ricardo Andrade
Published: September 2020

Resumo Introdução A goiaba é um fruto amplamente utilizado como alimento e é considerada planta medicinal em países tropicais e subtropicais. Pesquisas têm mostrado que o fruto contém constituintes químicos com abrangente uso clínico. Além disso, a maior parte das substâncias utilizadas no tratamento contra câncer foi isolada a partir de produtos naturais. Objetivo Avaliar o potencial citotóxico, mutagênico, antimutagênico e quimioprotetor da fruta liofilizada de Psidium guajava, a goiaba, in vivo. Método A citotoxicidade, a mutagenicidade e a antimutagenicidade foram avaliadas em três diferentes dosagens (0,625, 1,25 e 2,50 g/kg) de goiaba. Resultados Os resultados mostraram que a goiaba não apresentou atividade citotóxica e mutagênica no ensaio de micronúcleo em sangue periférico e que não houve alterações nos valores de ALT e AST, indicando ausência de toxicidade hepática. Nos animais tratados com a goiaba, a dose de 0,625 mg/kg significativamente reduziu os danos induzidos pela doxorrubicina. Conclusão Esses resultados mostraram que o consumo de goiaba é seguro e capaz de proteger o material genético de alterações genômicas.
Growth and yield of cactus pear under irrigation frequencies and nitrogen fertilization
Authors: Dantas Neto José , Matos Rigoberto M. de , Silva Patrícia F. da , Lima Antonio S. de , Azevedo Carlos A. V. de , Saboya Luciano M. F.
Published: September 2020

ABSTRACT Microirrigation associated with nitrogen (N) fertilization aims to meet the water and nutritional demands of cactus pear. The objective of this study was to evaluate the growth and yield of cactus pear (Opuntia ficus-indica) irrigated by microirrigation and fertilized with N. The experiment was conducted in the field at the Poço Redondo farm, Santa Luzia, PB, Brazil (6° 52’ 27’’ S and 36º 56’ 0’’ W and altitude of 299 m), between April and December 2017. The experimental design was in randomized blocks in a 5 x 2 factorial scheme, with five irrigation frequencies (7, 14, 21, 28 and 35 days) and two types of fertilization (soil fertilized with N and not fertilized) in the cultivar ‘Orelha de Elefante Mexicana’, with three replicates. Different irrigation frequencies promote reduction in green biomass yield and increase in the economic water productivity when using of the cladode for propagative material. Nitrogen fertilization increased growth, green biomass yield, water productivity and economic water productivity. The greatest economic return is obtained by producing cladodes marketed for propagative material. Reducing the frequency of irrigation promotes greater water saving, increasing the irrigated area and production by using less water at high frequency.
Atitudes de Estudantes de Medicina diante do Comportamento Suicida e Fatores Associados
Authors: Nunes Emerson Arcoverde , Oliveira Beatriz Bezerril de , Galvão Lucas Bezerril de Lima
Published: September 2020

Abstract: Introduction: To evaluate the self-confidence and knowledge of medical students when caring for patients at risk for suicide. Methods: A quantitative cross-sectional study was performed with a sample of 310 medical students from the campus of Universidade Federal do Rio Grande do Norte (UFRN) in Natal, Brazil. Data was collected through the application of the Suicide Behavior Attitude Questionnaire (QuACS, Questionário de Atitudes Frente ao Comportamento Suicida) in association with a sociodemographic questionnaire. The Spearman and Mann-Whitney correlation tests were used to analyze the data. Results: Students closer to the end of the course and those who had practical experience with suicide showed less negative feelings, more sense of professional capacity and less condemnatory attitudes towards suicide. Students in the beginning of the course showed more negative feelings towards suicide. There was no statistically significant influence of gender, having a friend or family member who attempted suicide or past experience of suicidal thoughts on the results. Conclusion: The study strengthens the correlation between the implementation of practical experience and capacitation activities with less negative feelings and increased sense of professional capacity to deal with suicidal behavior.
Psychometric Study of the Scale of Interests by Areas of Psychology - Portuguese Version
Authors: Ambiel Rodolfo Augusto Matteo , Martins Gustavo Henrique , Taveira Maria do Céu , Zuanazzi Ana Carolina , Martins Jucimara Zacarias , Cicchetto Airton Antonio
Published: September 2020

Abstract Considering the need to understand the variables related to the choice for Psychology specialties, this study aimed to present the adaptation process and to verify validity evidence based on the internal structure for the Portuguese version of the Scale of Interests by Areas of Psychology (EIAPsi) and relate it to personality. The sample consisted of 340 Portuguese university students, using the EIAPsi and the NEO Five-Factor Inventory (NEO-FFI). Exploratory Factor Analysis and correlations between instruments were performed. There was a factorial structure formed by 10 factors for the EIAPsi with satisfactory precision indexes. The dimensions of openness and agreeableness were the most frequently correlated to the areas of Psychology. We have concluded that evidence of initial validity of the instrument were presented, indicating possibilities of its use in the Portuguese context, specifically in situations aimed at self-knowledge (classroom or clinic/office) and guiding students in choosing their area of expertise.
Covid-19 - COVID-19 em uma Região Metropolitana: vulnerabilidade social e políticas públicas em contextos de desigualdades.
Authors: Chioro Arthur , Calife Karina , Santos Barros Cláudia Renata dos , Martins Lourdes Conceição , Calvo Marcos , Estanislau Evaldo , Amador Pereira Luiz , Caseiro Marcos
Published: September 2020

A COVID-19 chegou rapidamente na periferia das grandes cidades brasileiras, socialmente mais vulnerável. A baixa capacidade de testagem resulta na adoção de medidas sem informações consistentes sobre o comportamento da doença e interfere na adoção de ações de controle. Objetivos: estimar a prevalência de infecção por SARS-CoV-2 na população da Região Metropolitana da Baixada Santista (RMBS) e analisar impactos da vulnerabilidade social e de políticas públicas implementadas em contextos de desigualdades. Métodos: estudo de caráter quantitativo, transversal, através de inquérito sorológico seriado e aplicação de questionário em amostragem populacional estratificada e coleta domiciliar, nos nove municípios da RMBS. Conclusões: A soroprevalência medida foi de 1,4% na primeira fase e de 2,2 % na segunda permitindo estimar 15 pessoas infectadas para cada caso notificado na primeira fase, e 10 na seguinte. A letalidade foi recalculada para 0,40% e 0,48 % em cada fase, aproximando-se da casuística internacional. Pessoas mais vulneráveis são as mais atingidas pela pandemia, devendo ser consideradas: a informalidade no trabalho, baixa renda, cor da pele auto referida como preta ou parda e informações ambivalentes quanto à prevenção. Os resultados reforçam a importância do isolamento social e de adoção de medidas econômicas e sociais protetivas destinadas às populações vulneráveis.
Flexural behaviour of RC beams substituted with GFRP reinforcement in aggressive environments
Authors: Gopal Ramesh , Krishnachandran Sethumadhavan
Published: September 2020

Reinforced concrete (RC) in aggressive environments has higher concrete clear cover provided to protect the reinforcement against corrosion. However, providing such higher cover in severe environments could result in increased crack widths for the structural member. Hence, using a combination of fibre-reinforced polymer (FRP) bars and steel reinforcement bars (hybrid reinforcement) has been considered as a suitable solution to develop the full flexural capacity of the section without significantly affecting the serviceability and ductility requirements. This includes utilising the non-corrodible nature of FRP by adding a layer of longitudinal reinforcement made of FRP bars at the corner areas of the cross-section and keeping the main steel reinforcement at sufficient cover depth. This paper studies the flexural behaviour of hybrid glass-fibre-reinforced polymer (GFRP) beams consisting of continuous GFRP bars along with conventional steel reinforcement and comparing them with conventional RC beams through experimental and analytical studies. The test results indicated that the hybrid GFRP beams possess better flexural strength and ductility compared to conventional RC beams and could be considered as a suitable alternative to replace RC beams in aggressive environments.
MEMORY AND IDEOLOGY IN MOHSIN HAMID’S THE RELUCTANT FUNDAMENTALIST
Authors: ÇELİKEL Mehmet
Published: September 2020

Mohsin Hamid’s The Reluctant Fundamentalist, published in 2007, is a novel that focuses on the ideological standpoint of a young Pakistani man, Changez, who seeks for a solid standing ground in his own cultural origins after his educational and professional life in the US that westernized him fully. The novel, narrated within a frame story, is set on a single evening in Lahore where Changez tells his life back in America to an American in a café. Changez’s narration follows the story of his past with flashbacks and he leads the reader through his ideological change. Thus, purpose of this study is to question Changez’s ideological change after the 9/11 attacks on the Twin Towers in New York 2001. As memory traces his own past through what he went under during the 9/11 attacks, his approach to his western acquaintance in the Lahore café changes. This paper, therefore, raises questions as to whether memories change one’s ideology in terms of their political stance, or one’s cultural origins that determine them.