bluuebunny/crossref_metadata_2025 huggingface dataset:
The transfer of knowledge on integrated care among five European regions: a qualitative multi-method study
Authors: Grooten Liset , Vrijhoef Hubertus Johannes Maria , Alhambra-Borrás Tamara , Whitehouse Diane , Devroey Dirk
Published: December 2019

Background To examine how the knowledge transfer processes unfolded within SCIROCCO, a EU funded project (3rd Health Programme (2014-2020)) that aimed to facilitate the process of knowledge sharing across five European regions, to speed up adoption and scaling-up of integrated care initiatives. Methods A qualitative multi-method design was used. Data collection methods included focus groups, project documents and action plans of the regions. The data was analysed using a qualitative content-analysis procedure, which was guided by the frameworks of knowledge exchange and the why, whose, what, how framework for knowledge mobilisers Results All five components (including the themes) of knowledge exchange could be identified in the approach developed on the knowledge transfer processes. The four questions and accompanying categories of the framework of knowledge mobilisation were also identified to a large degree. Conclusions The observed incorporation of distinct forms of knowledge from multiple sources and the observed dynamic and fluid knowledge transfer processes both suggest that SCIROCCO developed a comprehensive knowledge transfer approach aiming to enable the adoption and scaling-up of integrated care. Overall, the multi-method qualitative nature of this research has allowed some new and practical insights in the knowledge transfer activities on integrated care between several European regions. To obtain a clear understanding of the content of the knowledge transfer approaches, which could assist the operationalising of models to support the evaluation of knowledge transfer activities, it is strongly recommended that further research of this type should be conducted in other research settings.
Clinical evaluation of ultrasonic subgingival debridement versus ultrasonic subgingival scaling combined with manual root planing in the treatment of periodontitis: study protocol for a randomized controlled trial
Authors: Yan Yue , Zhan Yalin , Wang Xian'e , Hou Jianxia
Published: December 2019

Background: Periodontal diseases are regarded as the most common diseases of mankind. The prevalence rate of periodontal disease assumes the obvious growth tendency in the whole world, increased by 57.3% from 1990 to 2010. Thereby, effective periodontal therapy is still a long-term task and tricky problem. The goals of periodontal therapy are to eliminate the infectious and inflammatory processes. Root planing, in order to eliminate the “infected cementum”, is an important step in treatment of periodontitis since 1970s. Along with the understanding of endotoxin’s feature on root surface, the necessity of manual root planing has been gradually queried. Ultrasonic instruments wouldn’t remove the cementum excessively, which are more time-saving and labor-saving compared to hand instruments as well. Hence, an increasing number of dentists prefer to scaling with ultrasonic instruments only. However, the necessity of root planing has still been emphasized in the international mainstream views of periodontal mechanical treatment. Therefore, this study is devoted to compare the clinical effect of ultrasonic subgingival debridement and ultrasonic subgingival scaling combined with manual root planing, which taking the implementation of root planing as the only variable and more in line with the clinical situation, hoping to provide some reference to dentists. Methods/design: Forty adult patients who fit the inclusion criteria are being recruited from the Peking University Hospital of Stomatology (Beijing, China). By means of randomization tables, one quadrant of the upper and lower teeth is the test group and the other is the control group. Test group: ultrasonic subgingival scaling combined with manual root planing. Control group: ultrasonic subgingival debridement. In a 24-weeks follow-up period, plaque index, probing depth, clinical attachment loss, bleeding index, furcation involvement, mobility, and patient-reported outcome (visual analog scale for pain and sensitivity) will be observed and documented. Discussion: This study evaluates the effectiveness of ultrasonic subgingival scaling combined with manual root planing and ultrasonic subgingival debridement alone in nonsurgical treatment of periodontitis with a split-mouth design after 1, 3 and 6 months. The result of the trial will potentially contribute to an advanced treatment strategy of periodontitis with ideal clinical outcome. Trial registration: The study has been registered in International Clinical Trials Registry Platform (ICTRP) under the identifier number ChiCTR1800017122. Registered on 12 July 2018. Keywords: Peridontitis, Non-surgical periodontal therapy, Ultrasonic subgingival debridement, Root planing
Developing an experimental necrotic enteritis model in turkeys - the impact of Clostridium perfringens, Eimeria meleagrimitis and host age on frequency of severe intestinal lesions
Authors: Hardy Simon P. , Benestad Sylvie L. , Hamnes Inger Sofie , Moldal Torfinn , David Bruce , Barta John R. , Reperant Jean-Michel , Kaldhusdal Magne
Published: December 2019

Background: Necrotic enteritis is a significant problem to the poultry industry globally and, in Norway up to 30 % of Norwegian turkey grow-outs can be affected. However, despite an awareness that differences exist between necrotic enteritis in chickens and turkeys, little information exists concerning the pathogenesis, immunity, microbiota or experimental reproduction of necrotic enteritis in turkeys. In particular, it is important to determine the appearance of the gross lesions, the age dependency of the disease and the role of netB toxin of Clostridium perfringens . To this end, we report our findings in developing an in vivo experimental model of necrotic enteritis in turkeys. Results: A four tier (0-3) scoring system with clearly defined degrees of severity of macroscopic intestinal lesions was developed, based on 2312 photographic images of opened intestines from 810 B.U.T. 10 or B.U.T. Premium turkeys examined in nine experiments. Loss of macroscopically recognizable villi in the anterior small intestine was established as the defining lesion qualifying for a score 3 (severe intestinal lesions). The developed scoring system was used to identify important factors in promoting high frequencies of turkeys with severe lesions: a combined Eimeria meleagrimitis and Clostridium perfringens challenge, challenge at five rather than three weeks of age, the use of an Eimeria meleagrimitis dose level of at least 5 000 oocysts per bird and finally, examination of the intestines of 5-week-old turkeys at 125 to 145 hours after Eimeria meleagrimitis inoculation. Numbers of oocysts excreted were not influenced by Clostridium perfringens inoculation or turkey age. Among three different lesion score outcomes tested, frequency of severe lesions proved superior in discriminating between impact of four combinations of Clostridium perfringens inoculation and turkey age at challenge. Conclusions: This study provides details for the successful establishment of an in vivo model of necrotic enteritis in turkeys.
Methicillin-resistant Staphylococcus aureus in veterinary professionals in 2017 in the Czech Republic
Authors: Neradova Katerina , Jakubu Vladislav , Pomorska Katarina , Zemlickova Helena
Published: December 2019

Background Cases of colonization or infection caused by Methicillin-resistant Staphylococcus aureus (MRSA) are frequently reported in people who work with animals, including veterinary personnel. The aim of this study was to determine the prevalence of MRSA colonization among veterinary professionals. A total of 134 nasal swabs from healthy attendees of a veterinary conference held in the Czech Republic were tested for presence of MRSA. The stains were further genotypically and phenotypically characterized. Results Nine isolated MRSA strains were characterized with sequence type (ST), spa type (t) and Staphylococcal Cassette Chromosome mec type. Five different genotypes were described, including ST398-t011-IV (n=5), ST398-t2330-IV (n=1), ST398-t034-V (n=1), ST225-t003-II (n=1) and ST4894-t011-IV (n=1). The carriage of the animal MRSA strain was confirmed in 8 cases, characteristics of one strain corresponded to the possible nosocomial origin. Among animal strains were described three spa types (t011, t034, t2330) belonging into one dominating clonal complex CC11. Conclusion According to our results, the prevalence of nasal carriage of MRSA in veterinary personnel is 6.72%. Although we described an increase compared to the results of previous study (year 2008), the prevalence in the Czech Republic is still remaining lower than reported from neighboring countries. Our results also indicate that healthcare - associated MRSA strains are still not spread among animals.
Multistability in the epithelial-mesenchymal transition network
Authors: Xin Ying , Cummins Breshine , Gedeon Tomas
Published: December 2019

Background: The transitions between epithelial (E) and mesenchymal (M) cell phenotypes are essential in many biological processes like tissue development and cancer metastasis. previous studies, both modeling and experimental, suggested that in addition to E and M states, the network responsible for these phenotypes exhibits intermediate phenotypes between E and M states. The number and importance of such states is subject to intense discussion in the epithelial-mesenchymal transition (EMT) community. Results: Previous modeling eorts used traditional bifurcation analysis to explore the number of the steady states that correspond to E, M and intermediate states by varying one or two parameters at a time. Since the system has dozens of parameters that are largely unknown, it remains a challenging problem to fully describe the potential set of states and their relationship across all parameters. We use the computational tool DSGRN (Dynamic Signatures Generated by Regulatory Networks) to explore the intermediate states of an EMT model network by computing summaries of the dynamics across all of parameter space. We nd that the only attractors in the system are equilibria, that E and M states dominate across parameter space, but that bistability and multistability are common. Even at extreme levels of some of the known inducers of the transition, there is a certain proportion of the parameter space at which an E or an M state co-exists with other stable steady states. Conclusions: Our results suggest that the multistability is broadly present in the EMT network across parameters and thus response of cells to signals may strongly depend on the particular cell line and genetic background. Keywords: Epithelial-Mesenchymal transition; multistability; network models
A bibliometric analysis of systematic review/meta-analysis on dry eye disease
Authors: Zhang Yonggang , Ping An , Lyu Shuyuan
Published: December 2019

Background There was no citation analysis about systematic review/meta-analysis published on dry eye disease (DED). The objective of this study was to identify the citations of systematic review/meta-analysis published on DED and to provide information on the achievement and development of evidence-based dry eye research.Methods Web of Knowledge Core Collection was searched for all systematic review/meta-analysis relevant to DED. The number of citations, authorship, year, journal, country, and institution were analyzed for each study.Results A total of 29 systematic reviews/meta-analyses on DED published between 2009 and 2017 were included. The number of citations ranged from 0 to 63, with a medium of 8 citations. These systematic reviews/meta-analyses were from 10 countries, and 15 of them were from China. They were published in 21 journals. Ocular Surface published most studies (n =4), followed by International Journal of Ophthalmology (n =3). The journal with highest impact factor was Nutrition Reviews (IF=5.291 in 2016).Conclusion The citations of systematic reviews/meta-analyses on DED are still low. Further systematic reviews/meta-analyses are needed for providing more evidence for DED.
Experiences of women accessing family planning services in Malawi: A Grounded Theory Study
Authors: Chilinda Idesi Temwa , Cooke Alison , Lavender Dame Tina
Published: December 2019

Background The importance of modern contraceptive methods in averting unwanted pregnancies has been acknowledged in Malawi. Currently, the country has registered highest rates of unsafe abortions, slow decline in maternal mortality, unmet needs for contraception and a low contraceptive prevalence rate. Understanding why these rates exist is important. However, women’s views and experiences regarding uptake of family planning methods in Malawi have not been explored.Methods A grounded theory methodology was used. Data were gathered through in-depth interviews with women (n=18), men (n=10), healthcare workers (n=10); and non-participant observations of family planning clinic consultations (n=10) at three health centre settings in Malawi. Interviews, field notes and memos were analysed using constant comparative technique. Methods of open, axial and selective coding enabled subsequent conceptualisations until theoretical saturation occurred.Results The core category “disenabling environment prevents women’s family planning needs from being met” provides an understanding of women’s, men’s and healthcare workers’ experiences of contraceptive use and non-use. The disenabling environment contributed to shaping women’s family planning experiences. This was supported by three main categories: navigating the processes, disempowerment of women and learning by chance. Access to contraception use was influenced by personal beliefs and motivations, procedures to follow and inadequate resources. Women were disempowered from using contraception due to societal demands and cultural influences.Conclusion Findings from this study illuminate contextual issues into how women, men and healthcare workers experience family planning use and non-use in Malawi. A multifaceted strategy is required to support a woman’s family planning needs. At community level, awareness and education of family planning methods is required to actively inform all people in society so that they support a woman’s family planning needs. At national level, laws that would empower women with decision-making ought to be developed and enforced.
Prevalence of shisha smoking and risk factors among female adolescents in Iran
Authors: Bashirian Saeed , Barati Majid , Karami Manoochehr , Hamzeh Behrooz , ezati elahe
Published: December 2019

Background: shisha smoking is on the increase in Iarn, but there are limited data on its use among adolescents. This research purpose is to the survey prevalence of shisha smoking and risk factors among female in Iran. Methods: This was a cross-sectional study . The study participants was 1302. The sampling was multistage random. 12 schools from three sectors of Kermanshah in the western city in Iran( 4 schools from each sector), were selected. Students were in grades 7 to 12. data were collected using questionnaire and analyzed by descriptive statistical methods and Logistic regression test by using SPSS 22 software. Results: The mean (SD) ages of the students and the ages when the participants started SS were 15.22 ± 1.85 and 13.64 (1.64) respectively. 32.4% of the participants ever having used a shisha and 20.4% mentioned they used shisha the last 30 days. Most of the subjects smoked shishas in friends’ houses (45.8%) and with their friends (47.4%). The significantly important factors that affect SS in these age groups were the father's and mother's occupation, family size, living with others, father's education, having a friend who smokes shishas, friends’ encouragement to smoke shisha, and being in a family that smoke shishas. Conclusions: shisha smoking has become a major concern in female . shisha prevention needs extensive studies. Investigation of shisha behavioral factors is essential in designing of educational interventions. Key words: Female, adolescents, student, shisha smoking .
Social participation needs of older adults living in a rural area: Toward reducing situations of isolation and vulnerability
Authors: Levasseur Melanie , Routhier Sonia , Clapperton Irma , Doré Chantal , Gallagher Frances
Published: December 2019

Background: Social participation is critical in fostering community vitality, promoting health, and preventing disabilities, but is restricted for approximately half the older adult population. Social participation involves social and leisure activities, such as visiting friends, bowling, etc., that meet fundamental needs for interaction, well-being and self-actualization. Although targeted through interventions by community organizations, healthcare professionals and municipalities, little is known about the needs of older adults to participate socially, especially in rural areas. This study thus aimed to identify and prioritize the social participation needs of older adults living in a rural area. Methods: A participatory action research was conducted in a rural regional county municipality (RCM) in Quebec, Canada with convenience sample of 139 stakeholders, including older adults, caregivers, healthcare and community organization managers, healthcare and community organization workers, RCM partners and key informants. Results: Facilitators and barriers to social participation related to personal factors (e.g., health, interests, motivation), the social environment (e.g., availability of assistance or volunteers) and the physical environment (e.g., distance to resources, recreational facilities and social partners). Nine needs emerged and were prioritized as follows: 1) having access to and being informed about transportation options, 2) being informed about available activities and services, 3) having access to activities, including volunteering opportunities, suited to their interests, schedule, cost, language and health condition, 4) being accompanied to activities, 5) having access to meeting places near home and adapted to their health condition, and 6-9 (no preferred order) being reached when isolated, being personally invited and welcomed to activities, having a social support network, and being valued and recognized. Differences emerged when prioritizing needs of older adults with disabilities (greater need for assistance, accessibility and adapted activities) and older adults living in a rural area (greater need for transportation).Conclusions: To promote active participation in the community, the social participation needs of older women and men living in rural areas must be addressed, especially in regard to transportation, information, adapted activities, assistance and accessibility. The first part of this action research will be followed by community selection and implementation of initiatives to ultimately foster their social participation.
The relationship between Hyperuricemia and Contrast-induced acute kidney injury undergoing primary percutaneous coronary intervention: the protocol of secondary analysis for ATTEMPT RESCIND-1 study
Authors: Guo Wei , Song Feier , Chen Shiqun , Zhang Li , Sun Guoli , Liu Jin , Chen Jiyan , Liu Yong , Tan Ning
Published: December 2019

Background: Contrast-induced acute kidney injury (CI-AKI) contributes toward unfavorable clinical outcomes after primary percutaneous coronary intervention (pPCI). We assessed whether hyperuricemia is an independent predictor of CI-AKI and outcomes in patients undergoing pPCI. Methods/design: Our study was a secondary analysis for the database from ATTEMPT study, enrolling 560 ST-segment elevation myocardial infarction (STEMI) patients undergoing pPCI. Eligible patients received peri-procedural either via aggressive (left ventricular end-diastolic pressure guided) or routine (<=500ml) intravenous hydration with the isotonic solution (0.9% NaCl) with randomization. The primary endpoint was CI-AKI, defined as >25% or 0.5 mg/dL increase in serum creatinine from baseline during the first 48-72 hours post-procedurally. Patients were divided into 2 groups according to the admission serum uric acid (SUA) level. Hyperuricemia was defined as a SUA level >7 mg/dL (417 mmol/L) in males and >6 mg/dL (357 mmol/L) in females. Multivariate analyses for CI-AKI and long-term mortality were performed using the logistic regression and Cox regression analyses, respectively. Discussion: This study will determine the predictive value of hyperuricemia for the development of CI-AKI and outcomes in patients with STEMI undergoing pPCI. We predict that hyperuricemia will be associated with a risk of CI-AKI in patients with pPCI. Furthermore, after adjusting for other variables, long-term mortality after pPCI was higher in those with hyperuricemia than in those with normouricemia. Results of this study may provide scientific evidence for the effect of hyperuricemia on CI-AKI and long-term outcomes, thereby offering the potential possibility of lowering SUA on the development of CI-AKI and outcomes.
In vitro and in silico Evaluation of Some Natural Molecules as Potent Glutathione Reductase Inhibitors
Authors: AYDİN Tuba
Published: December 2019

Glutathione
reductase inhibitors are very popular antimalarial and anticancer agents. In
this study, in vitro inhibition effects of β-sitosterol,
stigmasterol, diosgenin and jervine which containing steroidal structure were
determined against glutathione reductase enzyme. β-sitosterol, diosgenin
and jervine were isolated from Veratrum album and stigmasterol was
isolated from Artemisia dracunculus L. by chromatographic methods.
According to the results obtained, IC50 values of β-sitosterol,
stigmasterol, diosgenin and jervine were found as 1.2580, 5.2116, 0.1916 and
0.7701 µM, respectively. Among test compounds, diosgenin showed the strongest
inhibitory effect against glutathione reductase with Swissdock docking figure.
In current study first time, β-sitosterol, stigmasterol, diosgenin and
jervine were found to be much more glutathione reductase inhibitors.
Managing energy consumption: a case of natural gas as a taxation tool in Ukraine
Authors: Goncharuk Anatoliy , Figurek Aleksandra , Truba Vyacheslav , Nyenno Iryna
Published: December 2019

Energy consumption is managed to some degree in different countries. If the government is interested in reducing the energy poverty and increasing the energy consumption, it provides enough energy access for all consumers. However, sometimes, in order to regulate the energy market properly, the government should pursue other goals, i.e., political, economic, or even fiscal. This study aims to figure out how the new natural gas policy of Ukrainian government reflects on the main stakeholders’ incomes and expenses: the profits of domestic gas companies; the expenses of the four main groups of households by income. The article shows the case of unfair taxation of households’ natural gas consumption by the Ukrainian government that was named by the authors as “gas tax.” Analyzing this case using the statistical indicators of dynamics, distribution and structure, it was found out that the honest taxpayers who receive middle incomes (middle class) are in the most disadvantaged position because they are forced to pay the highest price and the largest share of their income for utilities. The paper also includes distinguishing several shortcomings and ethical problems that appear during application of the gas tax in Ukraine: growth of cost inflation, reduction in domestic consumption, reducing the profitability of business; reducing the middle class and increasing the stratification of society, concealment of real incomes and growth of the shadow economy, enhancing injustice and labor migration abroad. All these problems are the arguments for reconsidering gas tax to make it fair and less painful for the economy and households.
PULMONER HİPERTANSİYONLU BİREYLERDE KİNEZYOFOBİ
Authors: ERTAN Özge , KURAN ASLAN Gökşen , AKINCI Buket , OKUMUŞ Nigar Gülfer
Published: December 2019

Amaç: Bu çalışmanın amacı pulmoner hipertansiyonlu (PH) bireylerde kinezyofobinin egzersiz

kapasitesi, günlük yaşam aktiviteleri (GYA) ve yaşam kalitesi ile ilişkisini araştırmak ve demografik

ve klinik özelliklere göre karşılaştırmaktı.

Yöntem: Çalışmaya 37 PH’li hasta dahil edildi. Kinezyofobi değerlendirmesi, Kalp İçin Tampa

Kinezyofobi Derecelendirmesi (KTKD) ile yapıldı. Yaşam kalitesi, Nottingham Sağlık Profili (NSP)

ile belirlendi. Günlük yaşam aktiviteleri, London Chest Günlük Yaşam Aktiviteleri Ölçeği (LCGYAÖ)

ile değerlendirildi. Egzersiz kapasitesi, altı dakika yürüme testi (6DYT) ile ölçüldü ve 6DYT mesafesi

hesaplandı.

Sonuçlar: KTKD toplam skor, 6DYT sonrası dispne algılaması (p=0,016), NSP toplam skoru

(p=0,024), NSP alt gruplarından emosyonel reaksiyonlar (p0,05). Çoklu doğrusal regresyon analizinde;

dispne algılaması (p=0,006) ve emosyonel reaksiyonların (p
AYAK BİLEĞİ EKİN DEFORMİTESİ OLAN TİP 2 DİYABET HASTALARINDA GERME EGZERSİZİNİN AYAK TABAN BASINCINA AKUT ETKİSİ
Authors: YURT Yasin , MIHÇIOĞLU Serpil , MALKOÇ Mehtap , UZUNER Selma , SEZEREL Buse , TOMAÇ Hayriye
Published: December 2019

Amaç: Plantar fleksör kısalığına bağlı olarak gelişen ayak bileği ekin deformitesinin, tip 2 diyabeti

olan bireylerde ön ayak taban basıncını artırarak ülser oluşumuna neden olduğu bilinmektedir.

Amacımız ayak bileği ekin deformitesi olan tip 2 diyabetli bireylerde germe egzersizinin ayak taban

basıncına akut etkisini incelemekti.

Yöntem: Ayak bileği ekin deformitesi olan toplam 25 tip 2 diyabetli birey araştırmaya dahil edildi.

Bireylerin 21’i bilateral ve dördü unilateral ekin deformitesine sahip olduğu için, toplam 46 ayak

analiz edildi. Ekin deformitesi, diz ekstansiyonda iken ayak bileğinin 0°’den az dorsifleksiyonu olarak

tanımlandı. Ayak taban basıncı ölçümü için pedobarografik platform kullanıldı ve ayak tabanı 10

bölgeye ayrılarak tepe plantar basınç değerleri hesaplandı. Duvar kenarında 10 tekrarlı yapılan

plantar fleksör germe egzersizi öncesinde, hemen sonrasında ve aradan bir saat geçtikten sonra

aynı ölçüm tekrarlandı.

Sonuçlar: Germe egzersizinin hemen sonrasında yapılan ölçümlerde, dördüncü metatars bölgesi

hariç tüm metatars başlarında tepe plantar basınç azaldı (p0,05).

Tartışma: Plantar fleksör kısalığı bulunan tip 2 diyabetlilerde tek setlik germe egzersizi ile ön ayak

taban basıncı kısa süreli olarak azalmaktadır. Plantar fleksörlerin esnekliğinin uzun süreli egzersiz

programları ile artırılması diyabetiklerde artmış olan ön ayak ülserleri riskini azaltabilir.
The impact of the winery's wastewater treatment system on the winery water footprint
Authors: Saraiva A. , Rodrigues G. , Mamede H. , Silvestre J. , Dias I. , Feliciano M. , Oliveira e Silva P. , Oliveira M.
Published: December 2019

In the Mediterranean region, water scarcity has already prompted concern in the wine sector due to the strong impact it has on vineyard productivity and wine quality. Water footprint is an indicator that takes account of all the water involved in the creation of a product and may help producers to identify hotspots, and reduce water consumption and the corresponding production costs. In recent years several studies have been reported on wine water footprint determination, but mostly focused on the viticulture phase or assuming no grey water footprint at the winery since it has a treatment system. In the framework of the WineWaterFootprint project a medium-size winery was monitored, with direct measurements, regarding determination of the blue and grey components of water footprint. The determined winery water footprint ranged from 9.6 to 12.7 L of water per wine bottle of 0.75 L, the wastewater produced being responsible for about 98%, which means that the grey component cannot be disregarded. The developed scenarios show that a potential reduction of 87% in winery water footprint can be obtained with almost no investment. The challenge of reducing the grey footprint is not in technology development, but rather in the proper maintenance and monitoring of treatment systems.
The Role of the Constitutional, Supreme Arbitration and Supreme Courts in the Development of Russian Law
Authors: Nikolaeva Svetlana Sergeevna , Fortova Lubov Konstantinovna
Published: December 2019

This article discusses the role of the Constitutional, Supreme Arbitration and Supreme Courts in the development of Russian law, and also provides an analysis of public policy and lawmaking.
Innovative development of the Arctic zone of the Russian Federation
Authors: Khoiutanov Anatolii Nikolaevich
Published: December 2019

The article substantiates the need for innovative technologies in the development of the Arctic zone of the Russian Federation, identifies promising areas for the development of innovations.
U.S. consumer price index in the second half of XX century: calculation strategy and ways of its changes
Authors: Kozlova M. A.
Published: December 2019

The purpose of this research is a detection of U.S. consumer price index development and change ways emerged in the second half of XX century. Consumer price index is considered as a practically evaluable index number.

Materials and methods. This research is based on the methodology documents of U.S. Bureau of Labor Statistics and its theoretical and practical papers published in Monthly Labor Review. The basic method is historical and descriptive techniques.

Results. Data generalization for U.S. consumer price index across five revisions is realized in structure of the calculation method, adapted by ROSSTAT for the national consumer price index. Firstly the dynamic of number of cities, included in consumer price survey and changes of its sample is analyzed. Secondly the principles of point of purchase sampling is in focus. Thirdly the set of goods and services and dynamics of its structure are considered. Fourthly there is a generalization of pricing procedure principles that is frequency according to the type of cities and feature of goods and services. Fifthly the source and limits of data collecting for weights which needed for consumer price index calculation on the high level of aggregation. And sixthly there is description of mean price and price index calculation.

Conclusion. The main ways of development and transformation in U.S. consumer price index are defined. It may be considered as alternative solutions in consumer price index of other countries. The main ways are the increase of city and goods sampling, extension of probability use, formation of good classification, equal temporal interval of weight renovation and creation of price index system.
Edematous form of the Hemolytic Disease of the Fetus and Newborn
Authors: Pukhtinskaya M. G. , Estrin V. V. , Porutchikovа Yu. A. , Simonovа A. V.
Published: December 2019

Clinical observation of a premature newborn patient with an edematous form of the Hemolytic Disease is presented. A feature of this case is its relative rarity in view of the favorable outcome of the most severe form of hemolytic disease in an extremely severe initial condition of the fetus.
Comparative analysis of clinical manifestations of primary hyperparathyroidisis by results of hospitalizations and screening for hypercalcia in the Arkhangelsk region
Authors: Baranova I. A. , Zykova T. A. , Sergeeva O. A.
Published: December 2019

Objective: to compare the forms and clinical course of primary hypeparathyroidism in hospitalized patients over a ten-year period, with patients identified by a routine analysis of blood calcium in Arkhangelsk region.

Material and methods: At the first stage, a retrospective analysis of 48 case histories of patients who received inpatient treatment for PHPT in two multidisciplinary hospitals in Arkhangelsk from 2005 to 2015 was carried out. At the second stage, a screening of blood calcium was performed in patients of large outpatient clinic in Arkhangelsk from March 1 to March 31, 2015, as a result of which 21 cases of the first established PHPT were detected. A comparative analysis of the clinical course was carried out in two groups of patients with PHPT compared with the control group.

Results: patients with PHPT detected during screening showed a higher incidence of mild forms of the disease (38 %), a higher level of bone mineral density in all parts of the skeleton according to dual-energy X-ray absorptiometry, and a lower incidence of nephrolithiasis (24 % vs. 69 %) compared with hospitalized patients, among which the manifest forms of the disease prevailed (88 %), fibrocystic osteitis was detected in 44 % of cases, and coral nephrolithiasis - in 10% of cases.

Conclusion: a routine study of blood calcium levels helps to identify primary hyperparathyroidism at earlier stages to prevent the development of severe complications and invalidisation of patients.
Age features of arterial human kidney vessels
Authors: Kaplunova O. A.
Published: December 2019

Objective: to study the structural transformations of the architectonics of intra-organ renal arterial vessels in the age aspect.

Materials and methods: 150 kidneys of people of diff erent age who died from the reasons which are not connected with diseases of cardiovascular and urinary systems are investigated. The studies were carried out using a set of methods: angiographic, macromicroscopic and morphometry.

Results: with increasing age, a decrease in the number of vascular glomeruli in the kidney, the proportion of glomerular mass in the cortical substance of the kidney was found. In old age and in centenarians, a rare capillary network in the cortical substance of the kidney, tortuosity, narrowing and expansion of direct arterioles and capillaries in the cerebral substance was revealed. In old age and in centenarians, compared with adolescence, the relative content of arterial vessels in the cortical substance decreases by 6 times, in the juxtamedullary zone — by 4 and in the cortical substance — by 2 times.

Conclusions: the large diameters of the juxtamedullary glomeruli and a large index of the relative content of arterial vessels in the juxtamedullary zone create prerequisites for possible juxtamedullary shunting with urgent adaptation in the norm. The decrease in these indicators in old age, the elderly and centenarians, obviously, explains the age-related decline in the adaptive capacity of the arterial bed of the kidneys. With increasing age, the range of adaptive capabilities of the renal vascular bed of aging people decreases compared to those of mature age.
Non-suicidal self-harming behavior of adolescents
Authors: Darin E. V.
Published: December 2019

Th e article discusses non-suicidal self-harming behavior (NSPP) in adolescents, which is currently a widespread problem both in the Russian Federation and around the world. Th e main types and forms of NSPP, the causes and mechanisms of occurrence, the diff erence from other forms of self-destructive behavior are considered.
Functional features of innate immunity in the development of postpericardiotomy syndrome in patients after coronary artery bypass grafting
Authors: Shlyk I. F. , Sizyakina L. P. , Sidorov R. V. , Shlyk S. V.
Published: December 2019

Objective: to study the functional characteristics of innate immunity in the formation of postpericardial syndrome (PPS) in patients undergoing coronary artery bypass graft ing (CABG).

Materials and methods: the study involved 60 people, 40 of them made up the main group of patients with coronary artery disease, which retrospectively aft er 1 month of observation was divided into 2 groups. Group I CABG and PPS, group II CABG without PPS. The control group consisted of 20 patients without IHD. Before surgery, aft er 5, 14 days and 1 month, the expression of toll-like receptors (TLRs) 2, 4, 9, the content of CD16+ and Granzyme B lymphocytes, the HCT test and serum α-defensin were evaluated in blood cells. Statistical analysis of the results of the study was carried out using the program Statistica 12.0 (StatSoft , USA). The difference in mean values between groups was evaluated by the Mann-Whitney test. Statistical signifi cance was considered signifi cant at p ≤ 0.05.

Results: when comparing the initial indices of the main groups and the control group, an increase in the expression of TLRs 2, 4, 9 was revealed. An increase in the content of CD16+, as well as an increase in the cytotoxic activity of natural killers and an increase in the production of α-defensin.

Conclusions: on the basis of the study, activation of the cellular link of innate immunity, an increase in the cytotoxic potential of natural killers and a signifi cantly high level of α-defensin both before and aft er CABG were revealed, which can play an important role in the development of PPS.
Reference intervals of the magnesium in the healthy individuals, residents of Astrakhan
Authors: Petrova O. V. , Nikulina D. M. , Martirosov M. U.
Published: December 2019

Objective: to establish reference serum magnesium intervals in healthy individuals, residing in Astrakhan.

Materials and methods: the investigated group was formed from 120 men and 120 women healthy residents of Astrakhan aged from 21 to 50 years (average age 37,6 ± 0,9). Th e study of calcium was carried out on an automatic biochemical analyzer “Cobas 311 c” (Roche Diagnostic, Germany) by photometric method.

Results: the reference intervals for the magnesium in healthy men and women aged from 21 to 50 years, residing in Astrakhan is 0,72 – 0,99 mmol/L.

Conclusion: the reference range of total magnesium, established by us, can be used in laboratories of Astrakhan, as it was developed taking into account domestic and foreign recommendations for selection donors for research and ensuring the quality of laboratory research at all stages.
Onset of multiple myeloma with rheumatic polymyalgia
Authors: Israelyan E. R. , Golovataya C. S. , Bondarenko O. K. , Nayda A. V. , Pudeeva A. K.
Published: December 2019

A clinical observation of a patient presented with a typical clinic of rheumatic polymyalgia (RPM), which was a manifestation of myeloma. The relationship between rheumatic polymyalgia and giant cell arteritis (GCA) is well known, but association of RPM with lymphoproliferative diseases is rarely reported. In this case there was a clinical improvement in the patient’s condition aft er chemotherapy treatment.
Kesesuaian Kompetensi Soft Skill Lulusan Program Studi Bahasa/ Sastra Jepang Dengan Kebutuhan Dunia Kerja
Authors: Dwiwardani Wury , Wahidati Lufi
Published: December 2019

One of the efforts to improve the quality of human resources is by building links and matches between educational institutions and industry.  This link and match will support the growth of skilled human resources who can contribute optimally in various fields. In this regard, the question that often arises is whether universities, as institutions that play a role in educating young people, have produced graduates who have competencies that are in line with the needs of the industries. This research was conducted to identify hard skills and soft skill s typically required by the industries related to Japan and needed to be mastered by the graduates of Japanese Language/Literature Study Program who are working as Japanese speaking professional. Besides, this research aimed to analyze the weaknesses and problems faced by Japanese speaking professional when carrying out their work. The research data were collected from Japanese speaking professionals and the representative from Japanese companies located in Indonesia using questionnaires and interviews. Data obtained were then analyzed by referring to several references, including the results of the research conducted by M.M. Robles (2012) related to hard skills and soft skill s. The study finding about the strengths and weaknesses of Japanese Language Study Program graduates in Indonesia, can lead to improvement of the Japanese language learning, especially Japanese language learning in universities in Indonesia. So that the results of the study are expected to be taken into consideration in preparing and developing the curriculum of Japanese Language Studies Program in Universities, not only in the Vocational School of UGM, but also in other institutions in Indonesia.
Incorporating Motor Aspects in a Competence- based Syllabus for Second Grade English Class in SD Muhammadiyah Jagalan
Authors: Nugraha Cisya Dewantara , Wiwitan Dian Ayu Septiani
Published: December 2019

This paper aims to describe the development and implementation of competence-based syllabus of English in the second grade class of SD Muhammadiyah Jagalan. The research data were collected through direct observation and interviews with teachers and headmaster in SD Muhammadiyah Jagalan. Quotes from several books and references were used to support the analysis. The result showed that there are five stages to incorporate motor aspect in developing a competence-based syllabus, namely implementing the principles, formulating the set of procedures, implementing the development process, and formatting and modelling the developed syllabus based on KBK. The developed syllabus was then implemented in the class. The result showed that the developed syllabus brought positive impact for the students’ learning process in class. The impact include the increasing attention of students to the material explained by the teacher in the class, the building up of student’s self-confidence, and the growing interest of students to participate in the class when the teacher gives assignments.
Piracy in Somalia: An Analysis of the Challenges Faced by the International Community
Authors: Karawita Amali Kartika
Published: December 2019

Piracy in Somalia is a phenomenon that has presented several challenges for the international community since the beginning of the 21st century. Effectively formulating a plan of action against piracy requires the willingness of the international community to work together by implementing strong multilateral operations between countries and understanding the social and economic difficulties faced by Somalia, which has given rise to the endemic and its expansion throughout the region. Eradicating piracy means tackling the issue on land by confronting Somalia’s extreme poverty and lack of economic opportunity as well as creating a comprehensive legal framework that will serve as a model to fight piracy. The objective of the present paper is to discuss the roots of piracy in Somalia and the cycle it created, as well as provide an analysis on the legal framework in place in order to judge its effectiveness on an international level. The method applied to lead this research is based on the analysis of reports from international bodies such as the UN and the ICC, as well as academic articles. The results have shown that piracy is the fruit of social, economic, and political issues that have enabled the phenomenon to spread and establish itself in the country.
The Role of the Ambon City’s Population and Civil Registration Office in Controlling Incoming Migration
Authors: Sururama Rahmawati , Nanuru Tiara
Published: December 2019

The objectives of this study are to find out the role of the Ambon City’s Population and Civil Registration Office in Controlling Incoming Migration and to find out the obstacles faced by the Ambon City's Population and Civil Registration Office in Controlling Incoming Migration. This study used a qualitative descriptive research method. Data Collection was obtained through observation, interview, and documentation. Data were analyzed using data reduction, display data, and verification. Primary and secondary data were used as the sources for analysis. The informants in this study were the chief of the Population and Civil Registration Office Ambon City and the Population Monitoring and Control Division, as well as the migrants. Ambon City’s Government, through the Population and Civil Registration Office, has carried out its duties as regulated by the Mayor of Ambon Regulation No. 17/ 2009 article 14 paragraph 2, namely: Coordinating the monitoring of urbanization of population and supervising the registration of population mobility flows. The constraints faced by the Ambon City population and civil registration office, namely: Most of the population who migrated to Ambon City did not report themselves so the authorities had difficulty monitoring the flow of urbanization and monitoring population mobility; inspected and supervised residents, who have not lived in Ambon city for six months, have moved to other areas; there is no effort and awareness of people who have been examined and under supervision to change by reporting personal data to the government.
Accreditation Challenges in Saudi Universities
Authors: Albaqami Saud
Published: December 2019

Quality assurance in higher education remains to be one of the most prominent fields of research at the present. In the Saudi Arabian Higher Education Institutions (HEIs), quality assurance is a relatively new concept and Saudi universities seem not to effectively implement quality assurance caused by the certain obstacles. As such, there are two objectives to be addressed; first, to explore the challenging of accreditation. A case studies involving Prince Sultan University and King Abdul-Aziz University was used to examine these questions. Data was collected using semi-structured interviews with both meso and micro levels, as well as document analysis and observation. A thematic analysis approach was taken to analysis the data. The findings of this study support the perceived use of many different standards based evaluative processes, which provide feedback from the various stakeholder perspectives. The findings also demonstrate perceived supportive factors of the commitment/support of leadership and management, awareness and orientation of employees/faculty. In addition, the findings also report that/faculty resistance and infrastructure limitations focused on financial and human capital constraints were perceived as inhibitive factors to QA.
Analogías misioneras en el Congo y el Brasil coloniales a finales del siglo XVII:
Authors: Sarzi Amade José
Published: December 2019

A comparative study between two missionary accounts which were written by two Capuchin priests: the French Martin de Nantes, author of (Relation Succincte et Sincère [...], 1707), and the Italian, Girolamo Sorrento (Breve e Succinta Relatione [...], 1692). This essay intends to highlight, through a rhetorical-literary study, the very similar modus operandi present in both texts, to achieve this objective, an imagological analysis of the descriptions about the evangelized people and the places of Brazil and Congo carried out by French and the Italian priests will be taken as starting point. Additionally, I will mention the main lines of every missionary ministry and I will pore over how their mission’s responsibilities were incorporated within their texts. Likewise, I will analyze the scriptural elements concomitant to the preacher’s zeal when performing their religious duties.