bluuebunny/crossref_metadata_2025 huggingface dataset:
SPiP: Splicing Prediction Pipeline, a machine learning tool for massive detection of exonic and intronic variant effect on mRNA splicing.
Authors: Leman Raphaël , Parfait Béatrice , Vidaud Dominique , Girodon Emmanuelle , Pacot Laurence , GAC Gérald LE , Ka Chandran , Ferec Claude , Fichou Yann , Quesnelle Céline , Aucouturier Camille , Muller Etienne , Vaur Dominique , Castera Laurent , Boulouard Flavie , Ricou Agathe , Tubeuf Hélène , Soukarieh Omar , Gaildrat Pascaline , Riant Florence , Guillaud-Bataille Marine , Caputo Sandrine , Moncoutier Virginie , Boutry-Kryza Nadia , Bonnet-Dorion Françoise , Schultz Ines , Rossing Maria , Quenez Olivier , Goldenberg Louis , Harter Valentin , Parsons Michael , Spurdle Amanda , Frébourg Thierry , Martins Alexandra , Houdayer Claude , Krieger Sophie
Published: February 2022

Modeling splicing is essential for tackling the challenge of variant
interpretation as each nucleotide variation can be pathogenic by
affecting pre-mRNA splicing via disruption/creation of splicing
motifs such as 5’/3’ splice sites, branch sites or splicing regulatory
elements. Unfortunately, most in silico tools focus on a specific
type of splicing motif, which is why we developed the Splicing
Prediction Pipeline (SPiP) to perform, in one single bioinformatic
analysis based on machine learning approach, comprehensive assessment of
variant effect on different splicing motifs. We gathered a curated set
of 4,616 variants scattered all along the sequence of 227 genes, with
their corresponding splicing studies. Bayesian analysis provided us the
number of control variants, i.e. variants without impact on
splicing, to mimic the deluge of variants from high throughput
sequencing data. Results show that SPiP can deal with the diversity of
splicing alterations, with 83.13% sensitivity and 99% specificity to
detect spliceogenic variants. Overall performance as measured by area
under the receiving operator curve was 0.986, significantly better than
0.965 spliceAI for the same dataset. SPiP lends itself to a unique suite
for comprehensive prediction of spliceogenicity in the genomic medicine
era. SPiP is available at:
[https://sourceforge.net/projects/splicing-prediction-pipeline/](https://sourceforge.net/projects/splicing-prediction-pipeline/)
Exploring Professional Development Needs and Strategies for Instructors/Faculty Facilitating ePortfolios Online
Authors: Hoven Debra , Walsh Pamela , Al-Tawil Rima , Zuba Prokopetz Rita
Published: February 2022

This qualitative study sampled 30 university websites across Canada to identify which Canadian universities offer ePortfolio activities to students and faculty members. The researchers from Athabasca University identified eight institutions as offering ePortfolio activities and aimed to explore how faculty or instructors of such ePortfolio activities were selected and what professional development (PD) opportunities were available to them. The study included 11 participants from the eight Canadian universities identified during our search of university websites mentioning ePortfolios. Through a descriptive and interpretive process in a series of 60–90-minute interviews with faculty, educational developers, and instructional designers at the identified universities, the four researchers explored the type of professional development offered to faculty members who are involved or will be involved in ePortfolio use and program integration. The main focus of their interviews was on 1) the nature and type of development offered; 2) how it has been organized; 3) to what extent it has been effective; 4) how faculty members are chosen to teach ePortfolio courses; 5) what lessons have been learned about these factors; and 6) what recommendations are offered or proposed by PD developers, facilitators, and faculty participants. Given that the use of ePortfolios is a rapidly emerging pedagogy in higher education, it is not surprising, perhaps, that faculty development has not kept pace with the practice of ePortfolio introduction. Preliminary results have revealed variations of ePortfolio use (or lack thereof) in higher education. The findings have also revealed the need for a Canadian ePortfolio community to enable practitioners, proponents, and researchers to build on each other’s knowledge, share experiences, and engage in the dissemination of open education resources housed in ePortfolio projects.
Electronic Portfolio: Reflective Project in a Community of Language Learners
Authors: Zuba Prokopetz Rita
Published: February 2022

In this article, I present my stance as an English as a second language (ESL) practitioner resulting from empirical observations of the development of eportfolio reflective projects by five groups of approximately 10-20 intermediate-level language learners in an online learning community during five iterations of the same course (February 2018-June 2020). I provide an insight into the experiences of ESL students with their first eportfolios as a capstone project based on ongoing observations grounded on theoretical concepts of the affective domain and a more ecological aspect of constructivism. The first four groups of 10-20 students completed their program of studies in a blended format – three days onsite and two online. The fifth group with 20 students, however, due to COVID-19, was thrust into learning entirely at a distance prior to the completion of their second module. In each cohort, students were aware of the remaining modules in their program of studies and waited in anticipation – and some form of trepidation – for their reflective project. The capstone eportfolio project was the fifth and final module in a five-month program of studies where students chose a platform for their projects (technology) and populated the pages with learning episodes (pedagogy) experienced in the previous four modules. These eportfolio projects, developed by the students individually and in collaboration with their peers, fostered engagement and feedback interaction at various stages. While developing their reflective projects, students learned to leverage eportfolio technology to enhance the achievement of their goals as well as eportfolio pedagogy to articulate the attainment of competencies. Since evidence of core competencies in each language skill ability is a program requirement, modules preceding the creation of eportfolios necessitate tasks that foster learner awareness related to language skills, abilities, and attitudes. Although students eventually understand what the competencies are, they often grapple with how they are attained, and why they are required. As reflective projects grounded on academic rigour and underpinned by theoretical principles, these eportfolios espouse self-awareness and deeper learning. As such, they foster student agency and empower creators to articulate their experiences as they reflect on the learning to date. My observations of five groups of language learners developing their first eporfolio as a capstone project may help inform the field of online pedagogy and also contribute toward a better understanding of eportfolios as reflective projects in blended and online learning communities.
Design and Development of Android Application for Doctors and Patients: Implications for Covid-19 Pandemic and Post Pandemic Uses
Authors:   Africa Regional Centre for Information Science University of Ibadan Ibadan, Nigeria, Ogunsola K , Akintoye A.G
Published: February 2022

The anxiety brought by the Corona Virus Disease (COVID-19) pandemic caused a lockdown across the world to ensure social distance. This has pushed health care services far from the reach of many people, especially people with other ailments other than COVID-19. Outpatients become reluctant to visit healthcare centres to avoid the long waiting time to consult a doctor. There are also the problems of scheduling and rescheduling of appointments between patients and doctors, which has affected communication between them. Many hospitals have restricted patients' visits to hospitals and encouraged patients to communicate with their doctors via mobile phones. This has necessitated for the design and development of an android-based application called Medipal that improves consultation and appointment scheduling processes between doctors and patients, as well as personal health record keeping by patients. The application also enables patients to personally keep their health information, thereby involving them in their health and wellness. The overall performance of the mobile application was satisfactory as the evaluation showed that it enabled users to save time and cost during appointment scheduling and consultation. The app was deemed useful as majority accepted that it made them more aware of their health information. The interface of the app was easily navigated as users were able to perform operations with ease. Further research and development can be carried out as this study creates a platform upon which better systems can be built. Keywords: Doctors, Healthcare, Medipal, Mobile Health Application, Mobile Technology, M-Health
Structural, biological and computational study of oxamide derivative
Authors: Filipovic Ignjat , Mrkalic Emina , Pelosi Giorgio , Kojic Vesna , Jakimov Dimitar , Baskic Dejan , Matovic Zoran
Published: February 2022

A dicarboxylato-diamide-type compound 2,2'-[(1,2-dioxoethane-1,2- -diyl)diimino]dibenzoic acid (H4obbz) (1) was synthesized and characterized. The crystal structure of K2H2obbz?2H2O (2) was determined by X-ray diffracttion analysis. The cytotoxic activities of the compounds were tested against four different cancer cell lines MCF-7, A549, HT-29, HeLa and a human normal cell line MRC-5. The results indicate reasonable dose-dependent cytotoxicity of the ligands that show selectivity against the tested carcinoma and healthy cell lines. Flow cytometric analysis and fluorescence microscopy showed that the most active compound, H4obbz, induced apoptosis and G0/G1 cell cycle arrest, indicating blockage of DNA synthesis as a possible mechanism that triggers apoptosis. Docking and molecular dynamics simulations gave similar responses regarding interactions (binding) between their ligands and chaperon Grp78. The MMGBSA determined ?G binding energies were in the range from ?104 to ?140 kJ mol-1.
Metaphor Used in The News Items of Economy and Business Segments in The Jakarta Globe News Portal
Authors: Swandewi Komang Sri , Jaya Putra I Nyoman Adi , Agustini Dewa Ayu Eka
Published: February 2022

Penelitian ini bertujuan untuk menganalisis jenis metafora yang digunakan dalam segmen berita ekonomi dan bisnis di Portal Berita Jakarta Globe dan mengidentifikasi jenis metafora yang paling banyak digunakan di antara segmen berita ekonomi dan bisnis di Portal Berita Jakarta Globe. Desain penelitian ini adalah analisis wacana dengan pendekatan kualitatif. Objek penelitian ini adalah metafora. Subyek penelitian ini adalah segmen berita ekonomi dan bisnis di Portal Berita Jakarta Globe. Dalam mengidentifikasi metafora tertentu, metode yang digunakan adalah MIP (Metaphor Identification Procedure). Pengumpulan data dilakukan dengan menggunakan pengumpulan dokumen. Instrumen proses pengumpulan data yang digunakan peneliti, catatan, dan daftar periksa. Data dianalisis secara deskriptif dengan menggunakan model Miles dan Huberman. Temuan penelitian ini menunjukkan bahwa ada empat jenis metafora yang digunakan dalam segmen berita ekonomi dan bisnis di Portal Berita Jakarta Globe. Mereka adalah metafora struktural, orientasional, ontologis, dan antropomorfik. Metafora struktural muncul sebagai yang paling banyak digunakan dalam segmen berita ekonomi dan bisnis Portal Berita Jakarta Globe dengan total 61 metafora atau 78,20% dari metafora yang dianalisis.
Model Keterlibatan Pegawai dalam Entitas Non Profit di Era New Normal
Authors: Kesuma Yuliantari Anak Agung Ayu , Supriyadinata Gorda AA. Ngr. Eddy
Published: February 2022

Employee engagement merupakan wujud loyalitas karyawan terhadap perusahaan. Hanya saja kenyataan dilapangan menunjukkan bahwa tidak semua karyawan memiliki Employee engagement yang tinggi terhadap perusahaan. Adapun tujuan dari penelitian ini yakni untuk mengetahui dan menganalisis alasan kurang optimalnya keterlibatan pegawai dalam sebuah perusahaan. Penelitian ini tergolong kedalam jenis penelitian deskriptif kualitatif. Dengan subjek penelitian yakni penelitian yakni manajemen dan pegawai rumah sakit. Pengumpulan data dalam penelitian dilakukan dengan menggunakan metode observasi dan wawancara mendalam. Adapun instrument yang digunakan yakni pedoman wawancara dan observasi. Data hasil penelitian kemudian dianalisis dengan menggunakan Teknik analisis data kualitatif dengan model interaktif dari Miles dan Huberman. Verifikasi keabsahan hasil analisis dalam penelitian ini menggunakan cara triangulasi sumber data, artinya peneliti mengumpulkan data sejenis dari berbagai sumber data yang berbeda-beda. Hasil analisis penelitian menunjukkan bahwa belum optimalnya Employee engagement disebabkan oleh faktor budaya, indikator kesuksesan, penetapan prioritas, komunikasi, inovasi, akuisisi talenta, peningkatan talenta dan siklus pelanggan atau bisnis. Selain itu, disimpulkan juga bahwa identifikasi model upaya meningkatkan keterlibatan pegawai meliputi aspek lingkungan kerja, aspek kepemimpinan, aspek hubungan tim dan rekan kerja, aspek pelatihan dan pengembangan karir, aspek kompensasi, aspek kebijakan, prosedur, struktur dan sistem organisasi, serta aspek kesejahteraan di tempat kerja.
Tingkat Kinerja Karyawan Dan Faktor-Faktor Yang Mempengaruhi Kinerja Karyawan Yang Bekerja Dari Rumah (Work From Home) Selama Masa Pandemi Covid 19
Authors: Rombe Maria , Dongoran Johnson
Published: February 2022

Kinerja karyawan menjadi tindakan nyata yang ditampilkan sebagai hasil kerja yang telah dikerjakan oleh karyawan sesuai dengan perannya dalam suatu organisasi atau perusahaan. Penelitian ini bertujuan untuk menganalisis tingkat kinerja karyawan dan mengidentifikasi faktor-faktor yang mempengaruhi kinerja karyawan yang bekerja dari rumah selama pandemi Covid-19. Jenis penelitian ini merupakan penelitian kualitatif. Teknik pengambilan sampel menggunakan metode purposive sampling yaitu responden yang benar-benar bekerja dari rumah selama pandemi Covid-19 dengan jumlah 10 karyawan. Jenis data yang digunakan dalam penelitian ini adalah data primer yang diperoleh langsung dari jawaban responden melalui kuesioner. Data dianalisis menggunakan teknik analisis deskkriptif kualitatif. Hasil penelitian menunjukkan bahwa tingkat kinerja karyawan menurun atau kurang maksimal. Sedangkan faktor-faktor yang mempengaruhi kinerja karyawan yaitu motivasi, bonus, punishment, usia, latar belakang pendidikan, pengalaman kerja, latar belakang sosial budaya, lingkungan kerja, kepemimpinan, umpan balik rekan kerja, pengawasan dari atasan serta sistem upah. Adapun faktor lain yang mempengaruhi kinerja yaitu jaringan internet yang kurang stabil, fasilitas kurang memadai, kepuasan kerja, target penjualan, ruang gerak terbatas dan miskomunikasi.
Dampak Pemotongan Gaji pada Perusahaan dan pada Karyawan Selama Masa Pandemic Covid 19
Authors: Sampe Putri Diana , Dongoran Johnson
Published: February 2022

Pandemi covid-19 memberikan dampak negarif bagi prekonomian, salah satunya pada perusahaan yang mengambil tindakan pemotongan gaji bagi karyawan. Tujuan penelitian ini adalah untuk menganalisis dampak pemotongan gaji pada perusahaan dan pada karyawan selama masa pandemi covid 19. Jenis penelitian adalah penelitian kualitatif. Jumlah responden dalam penelitian ini adalah 10 responden yang terdiri dari satu pimpinan dan sembilan karyawan. Teknik pengambilan sampel menggunakan metode purposive sampling. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif. Jenis data yang digunakan dalam penelitian ini adalah data primer yang diperoleh langsung dari jawaban dari pimpinan dan karyawan yang dikumpulkan melalui kuesioner. Kuesioner yang digunakan adalah jenis kuesioner terbuka. Data dianalisis menggunakan teknik analisis deskriptif kualitatif. Hasil penelitian ini menunjukkan bahwa penurunan pendapatan karyawan akibat dari pemotongan gaji yaitu antara 15% hingga 20%. Dampak pemotongan pada perusahaan mencakup dua hal yakni keuangan perusahaan khususnya dalam sisi pengeluaran yang juga diharapkan bisa menopang kestabilan perusahaan dan beban kerja karyawan dikurangi, sedangkan dampak pemotongan gaji pada karyawan diantaranya yaitu sulit dalam mengelola atau mengatur keuangan, kredit-kredit yang menunggak, kebutuhan karyawan tidak sepenuhnya terpenuhi, beban ekonomi yang semakin meningkat sementara gaji dipotong, motivasi kerja menurun, rasa disiplin yang menurun, acuh tak acuh terhadap pekerjaan, dan hasil kerja yang tidak maksimal.
Ukuran Perusahaan, Return on Equity (ROE), Debt to Equity Ratio (DER), dan Operating Leverage (DOL) terhadap Perataan Laba pada Perusahaan Food and Beverages yang Terdaftar di Bursa Efek Indonesia
Authors: Panjaitan Desy Natalia , Afiezan H. Adam
Published: February 2022

Perusahaan yang mempunyai operating leverage tinggi akan mengalami peningkatan persentase yang besar dalam labanya jika terjadi sedikit saja peningkatan dalam penjualan Penelitian ini bertujuan untuk menganalisis ukuran perusahaan, return on equity (ROE), debt to equity ratio (DER), serta oeparting leverage pada perataan laba di perusahaan food and beverage pada Bursa Efek Indonesia total 50 perusahaan tahun 2016-2019. Teknik penentuan sampel pada riset ini memakai teknik purposive sampling, maka data akhir digunakan adalah 10 perusahaan. Metode pengumpulan data pada penelitian yaitu studi dokumentasi. Teknik analisis regresi linear berganda dipakai pada observasi ini. Berdasarkan pengolahan data koefisien determinasi, ditemukan nilai Adjusted R Square adalah 49,9%. Hasil studi menggambarkan jika ukuran perusahaan, return on equity, debt to equity ratio, operating leverage serta firm size memiliki pengaruh secara bersamaan serta signifikan pada nilai perusahaan di food and beverage yang tertera pada Bursa Efek Indonesia periode 2016 -2019. Secara parsial ukuran perusahaan berpengaruh positif signifikan terhadap perataan laba, return on equity memiliki pengaruh positif signifikan terhadap perataan laba, debt to equity berpengaruh positif signifikan terhadapn perataan laba, dan operating leverage memiliki pengaruh positif signifikan terhadap perataan laba pada perusahaan food and beverage di BEI tahun 2015-2019. Implikasi penelitian ini diharapkan dapat memberikan dampak pada peningkatan laba perusahaan.
One Million Dollar Private Practice
Authors: Koba Nataliia , Nagorniak Ivan
Published: February 2022

Someday the owner of the private dental and oral surgery practice can decide to sell it. In some cases, this is because the owner wants to move away from dental matters completely; To move away from business not only as a dentist or oral and maxillofacial surgeon but even as a shareholder. Regardless of personal motives for the sale, the deal and the cost of whole practice should not be underestimated.
The price is to be based on a correct calculation of the next dental clinic data: Human resources (number of specialists, types of their specialization, experience, etc.), number of dental chairs, equipment, package of state permits for dental business and types of dental specialties that are included in the license of this clinic to conduct business in medical practice, presence of ISO 9001 certification for the clinic, established connections with partners (dental technicians, companies of dental products and equipment, insurance companies, etc.), types of diagnostic, treatment, and prophylactic procedures carried out in the clinic, base of clients, availability of consulting doctors, existence of communications with University chairs and associations/societies, presence of cooperation agreement with Pathology Department, location of the branch of the chair on the basis of the clinic, number of years at the market, longevity of the same team (Woody [2018] notes that 10-plus years for the same team is one of the best indicators for buyers),1 the size of real estate, location in the country and in the city/village (distance from the neighboring countries, airports, metro stations, and other transport nodes), the commercial real estate is owned or leased, real estate is a separate building or included to the multiple apartment building, presence of the rooms for the educational or hands-on training, courses that have been performed on the basis of this clinic, team experience in organization of the dental meetings, a state and international reputation of the practice, etc.
EFEKTIVITAS METODE PEMBELAJARAN ROLE PLAYING UNTUK MENINGKATKAN KESANTUNAN BERBAHASA SISWA
Authors: Rayendra Rayendra
Published: February 2022

Penelitian ini dilatarbelakangi oleh rendahnya pemahaman kesantunan berbahasa siswa dan pelaksanaan pembelajaran yang masih menggunakan metode pembelajaran konvensional pada mata pelajaran Budaya Alam Minangkabau. Penelitian ini menggunakan metode penelitian kuasi eksperimen dengan pendekatan kuantitatif dan dengan desain nonequivalent-group pretest-posttest design yang bertujuan untuk mengetahui efektivitas dari metode role playing. Sampel pada penelitian ini adalah siswa Sekolah Menengah Pertama Negeri 11 Padang kelas VIII sebanyak 64 orang yang terbagi dalam dua kelompok. Hasil analisis data menghasilkan temuan bahwa metode pembelajaran role playing efektif meningkatkan kesantunan berbahasa. Hal ini terlihathasil penelitian diperoleh dari nilai rata-rata kelas eksperimen 73,406 dan kelas kontrol 62,781. Berdasarkan perhitungan uji Independent Samples Test (t-test) diperoleh t-hitung 5,728 pada taraf kepercayaan α 0,05 sedangkan t-tabel 2,000, sehingga t-hitung > t-tabel. Dengan demikian dapat disimpulkan penerapan metode pembelajaran role playing dapat meningkatkan kesantunan berbahasa siswa pada mata pelajaran Budaya Alam Minangkabau di Sekolah Menengah Pertama Negeri 11 Padang.
Politics of prevention in the periphery: The initial response to COVID-19 on Barbuda and Puerto Rico
Authors: Perdikaris Sophia , Abadie Roberto , Gonzalez Edith , Ibrahimpašić Emira
Published: February 2022

The islands of Barbuda and Puerto Rico share a history of dispossession and exploitation, occupying a peripheric position in a core–periphery world system. Yet, each island's response to COVID-19, and the subsequent effects of the pandemic, could not be more different. This paper examines how colonialism and neocolonialism affected the islands’ ability to respond to COVID-19. Barbuda relied on community traditions of support and self-reliance and was able to restrict all travel to and from the island, including travelers from the diaspora and those participating in its informal economic sector. In doing so, Barbuda effectively isolated itself from infection. On the other hand, Puerto Rico, in a protracted economic crisis, was particularly vulnerable to touristic flows, diasporic movements, and a large informal sector. The Puerto Rican response was shaped by deep politicization in the mainland U.S., which complicated an evidencebased strategy to combat the emergency. These cases show that islands, particularly those located in peripheric or subaltern spaces, cannot isolate themselves from the worst effects of COVID-19 through mere geography. Pandemics are not only driven by biological events but also by the narratives of colonialism, encompassing political, economic, and cultural factors, which determine their trajectories — sometimes with devastating outcomes.
Analyzing Iraqi Political Cartoons
Authors: Abdulwahid Huda Y.
Published: February 2022

Pictures have an essential effect on our thoughts and decisions.  We have also noticed how these pictures produced in the form of cartoons affect our viewpoints.  They do so since we are addicted to social media to the extent it can manipulate our thoughts unconsciously and obnoxiously. Besides, people don’t have the courage to express their viewpoints clearly, so they tend to use the satire to keep their face.  This motivates the researcher to analyze the underlying structure of this satire presented in caricatures to read the message clearly.  This research aims at revealing the way the political caricatures are produced and the main characteristics of political caricatures.  Incorporating a methodology depending on selecting some samples, this paper is a semiotic analysis of political caricatures announced through the election campaign 2018 in Iraq.  It concentrates on the format caricatures used as a communicative channel on net platform to come up with essential senses and prevailing political matters. This is carried out by adopting Barthes’ semiotic theory which is the first apparent semiotic approach. It is a good means to analyze the implied structure, including the dictionary and implied senses of creating influence of political caricatures. Besides, it provides us with a good means to interpret and understand political caricatures. This is quite important since political cartoons work as an approach to comprehend human consciousness.
Measuring Students' Critical Thinking
Authors: Zannrni Imadin M.
Published: February 2022

Staring from the increasing importance of Critical Thinking (CT), playing a key role in learning English as a second language, aiming to develop the educational situation in Kurdistan Region and Iraq as well as raising the awareness of the CT, and being one of the most prominent 4Cs the researcher has conducted this paper that examines three studies, their names will be mentioned afterward, in the field of critical thinking. Each study has got its own methodology, instruments, and goals so it has been a must to examine also to analyze the research methodologies, the findings, the discussions, and the research ethics. And, the researcher has tried to set a compromise among the findings.
Humor político en el live tweeting. Sus clases y circulaciones en la construcción de acontecimientos
Authors: Fraticelli Damián
Published: February 2022

El tuiteo de humor político sobre transmisiones televisivas es una práctica habitual que debe atenderse si quiere comprenderse cómo se construyen los acontecimientos en las sociedades actuales. Su existencia implica complejos procedimientos de apropiación colaborativa por parte de los internautas y también de los medios informativos que editorializan los eventos con sus memes. Aquí nos ocuparemos de describir de qué manera opera ese humor político enfocándonos en cómo actúan sus enunciadores, qué clases discursivas y tipos de circulaciones genera. Los eventos analizados son el primer discurso de apertura de las sesiones legislativas del presidente argentino Alberto Fernández, en marzo del 2020, y el debate en el Senado argentino de la Ley de Interrupción Voluntaria del Embarazo, en diciembre del mismo año. Su análisis nos posibilitó observar que el humor político del live tweeting tiene más retuiteos y likes que los tuits serios y que sus intercambios no se agotan en lo risible, sino que fomentan debates entre los internautas. A su vez, distinguimos cuatro clases discursivas (la sátira política, la burla, la situación cómica y el humor del colectivo) que implican modos diferentes de contactarse con el evento transmitido y circunscribimos modalidades de apropiación de las instituciones informativas.
Dampak Potensial Pengembangan Lembar Kerja Peserta Didik Berbasis Hots dengan Sistem Barcode Pada Mata Pelajaran PPKn
Authors:   Universitas Sriwijaya, Mariyan Mariyani , Setiyowati Rini , Fatihah Husnul
Published: February 2022

Penelitian ini dijalankan dengan maksud untuk menganalisa dampak potensial siswa terhadap pemahaman materi dan penilaian tingkat kepraktisan dari pengembangan lembar kerja peserta didik berbasis HOTS dengan sistem barcode dalam pelajaran PPKn. Dampak potensial yang ingin dicapai ialah kemampuan dalam meningkatkan daya berfikir kritis siswa. Lembar kerja siswa dikembangkan pada kajian ini berbasis HOTS dengan sistem barcode yang dapat digunakan lebih mudah karena bisa di akses melalui gawai. Hasil dari dampak potensial pengembangan lembar kerja peserta didik ini dilihat dari hasil pemberian angket untuk melihat tingkat kepraktisan lembar kerja peserta didik, pemberian tes yang didapatkan dari penyelesaian soal-soal berbasis HOTS saat pembelajaran berlangsung, serta observasi tidak langsung yang ditunjukkan dengan melihat antusiasme peserta didik ketika menerima materi. Metode kajian ini ialah kuantitatif deskriptif. Dengan memakai instrumen yaitu tes, angket dan observasi. Berdasarkan data hasil kajian yang dijalankan didapatkan hasil yang menjelaskan jika: 1) hasil angket menunjukkan persentase sebesar 84,53%. Hal ini menunjukkan jika lembar kerja siswa ini praktis untuk dipergunakan pada kegiatan pembelajaran, 2) hasil tes diperoleh perbandingan nilai rata-rata pretest sebesar 54,9 dan rata-rata nilai posttest senilai 79,0. Hal ini memperlihatkan jika ada selisih nilai sejumlah 24,1 yang berarti nilai hasil belajar peserta didik mengalami peningkatan setelah adanya lembar siswa dengan basis HOTS bersistem Barcode ini; 3) Berdasarkan hasil observasi yang dikonversi dalam bentuk angka sehingga diperoleh nilai rata-rata persentase nilai 84,3%. Nilai ini memperlihatkan jika respon peserta didik saat menjalani kegiatan pembelajaran atau kegiatan uji coba berlangsung bernilai baik. Maka didapatkan rata-rata persentase sebesar 84,3%. Hal ini menunjukkan bahwa pengembangan lembar kerja siswa berbasis HOTS dengan sistem Barcode dalam pelajaran PPKn memiliki dampak potensial baik dalam meningkatkan daya berpikir kritis. Oleh sebab itu pentingnya ketersediaan lembar kerja siswa yang mampu meningkatkan berpikir kritis dan mudah diakses.
Penguatan Pendidikan Kewarganegaraan Sebagai Upaya Diradikalisasi Generasi Muda
Authors:   Universitas Islam Syekh Yusuf,, fahmi rizal , Nadya Aisha , Rizki Adhari Nursanda , baynal hubi zindan
Published: February 2022

Pencapaian tujuan bangsa dan negara sangat ditentukan oleh kualitas sumber daya manusia, maka pendidikan memegang peranan penting dalam pembangunan peradaban yang dikenal dengan bangsa, memastikan bahwa setiap orang memiliki kemampuan untuk memiliki pengetahuan, sikap, dan keterampilan yang baik sesuai dengan keadaan masyarakat. Kelangsungan hidup suatu bangsa dan kemampuannya untuk berkembang menjadi bangsa yang lebih besar sangat tergantung pada karakter penduduknya, karena karakter menentukan cepat atau lambatnya tujuan negara tersebut dapat tercapai. Saat ini, yang mengancam keberlangsungan kehidupan bermasyarakat, berbangsa, dan bernegara adalah paham radikalisme, yang berupaya dengan cepat mengubah tatanan negara secara inkonstitusional. Radikalisme kini telah memasuki generasi muda, dengan tujuan utama meyakinkan mereka untuk menolak Pancasila sebagai ideologi dan UUD 1945 sebagai konstitusi negara. Atas hal itu, perlu ada inisiatif diradikalisasi dengan tujuan mengadopsi cita-cita Pancasila. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kepustakaan. Tujuan dari metode ini adalah untuk mengetahui pola-pola yang optimal digunakan dalam melaksanakan kegiatan diradikalisasi bagi generasi muda berbasis pendidikan kewarganegaraan, sehingga menghasilkan temuan-temuan yang menjelaskan bagaimana konsepsi ideal kegiatan diradikalisasi. Pendekatan diradikalisasi yang perlu digunakan oleh setiap komponen masyarakat meliputi pendekatan agama, negara, keamanan, dan kesejahteraan
Pemanfaatan Media Pembelajaran Daring Berbasis Youtube Sebagai Reaktualisasi Wawasan Nusantara Mahasiswa Di Masa Pandemi Covid-19
Authors:   Universitas Muhammadiyah Ponorogo, Cahyono Hadi , Sinta Utami Prihma , Puji Asmaroini Ambiro
Published: February 2022

Masa Pandemi Covid-19 berdampak pada proses pembelajaran di Perguruan Tinggi salah satunya pada pembelajaran wawasan nusantara, menjadi pembelajaran non tatap muka. Wawasan Nusantara merupakan salah satu muatan materi dalam mata kuliah Kewarganegaraan akan menjadi benteng bagi para mahasiswa atau generasi muda dalam menghadapi arus globalisasi yang sangat cepat dan tidak tentu. Melihat peluang YouTube yang begitu tinggi dalam menyebarkan informasi kepada publik, kami sebagai tim peneliti tertarik menggunakan YouTube sebagai fokus penelitian kami. Tujuan penelitian ini adalah untuk mengetahui sejauh mana pemanfaatan media pembelajaran daring berbasis youtube ini dalam mereaktualisasikan konsep wawasan nusantara pada mahasiswa di masa pandemic covid-19. Metode yang digunakan menggunakan deskriptif kualitatif dengan teknik pengumpulan data berupa observasi, kuesioner, tes, dan dokumentasi. Hasil temuan menunjukkan bahwa 96% mahasiswa telah lulus pada materi wawasan kebangsaan ini dengan mencapai skor atau nilai minimal yang dituntut sebesar 80 poin pada setiap mata kuliah. Sehingga bisa ditarik kesimpulan bahwa pemanfaatan YouTube dalam mereaktualisasikan wawasan nusantara pada mahasiswa di masa pandemi Covid-19 ini berjalan dengan baik dan berhasil.
NOD2 versus MEFV: Differential diagnosis of Yao syndrome and familial Mediterranean fever
Authors: Yao Qingping , Shen Min , Gorevic Peter
Published: February 2022

Objectives

Yao syndrome (YAOS, OMIM 617321) was formerly designated as nucleotide-binding oligomerization domain-containing protein-2 (NOD2)-associated autoinflammatory disease (NAID). This disorder shares similar clinical phenotypes with hereditary periodic fever syndromes (HPFS). This study aimed to compare YAOS with familial Mediterranean fever (FMF).

Methods

In this retrospective study, electronic medical records of a case series of YAOS were reviewed and data were analyzed. All patients underwent genetic testing for periodic fever syndrome 6-gene panel.

Results

A total of 6 cases were presented. These patients were initially thought to have MEditerranean FeVer (MEFV)-negative FMF and received treatment with colchicine. They were eventually diagnosed with YAOS. The differences between these diseases were illustrated. In addition, both MEFV and NOD2 mutations were detected in some patients and family members. Patients with carriage of both gene mutations may present with heterogeneous disease expression. A close correlation between phenotypes and genotypes is needed to make a diagnosis.

Conclusions

YAOS may mimic FMF. Molecular analysis should cover NOD2 whole gene sequencing to help distinguish these diseases. Both NOD2 and MEFV mutations may contribute to disease expression in an individual.
Top 100 cited articles on osteoarthritis from 1990 to 2020
Authors: Yin Feng , Yang Qiuyu , He Yue , Peng Lihui , Zhao Zixia , He Chengsong , Chen Jie
Published: February 2022

Objectives

The purpose of this study was to identify and analyze the 100 top-cited articles in the field of osteoarthritis (OA) from 1990 to 2020.

Methods

We used the Web of Science to retrieve the articles related to OA. Then we selected 100 target articles and manually collected their general information, including article title, author, year of publication, journal, type of article, and the number of citations.

Results

The 100 top-cited articles were published in the period from 1990 to 2015. These articles have been cited 66,494 times in total, with the highest being 2382 times, the lowest being 433 times, the median number being 613, and a mean of 664.94 times. The 100 top-cited articles appeared in a total of 35 influential journals. The greatest number of articles in the top of 100 was published in Arthritis and Rheumatism. The authors of these articles came from 18 countries, led by the United States (n = 48), followed by the United Kingdom (n = 15). Among all the institutions, Boston University led the list with 10 articles. The most prevalent type of the study was review (n = 38) and clinical study (n = 38), followed by guideline (n = 12), basic science (n = 10) and other types.

Conclusions

This study provided some insights on the literature development and citation of OA in the recent 30 years. Articles published in high-impact journals are more likely to be cited in the field of OA. As recent studies did not have enough time to accumulate the number of citations, the latest articles may not be included in the top 100 cited articles.
Severe asthma with viral infection can develop into eosinophilic granulomatosis with polyangiitis
Authors: Ou Changxing , Ma Jianjuan , Lai Ning , Li You , Xie Jiaxing , Zhang Xueyan , Zhang Qingling
Published: February 2022

Asthma is common in eosinophilic granulomatosis with polyangiitis (EGPA), and the annual incidence of EGPA in patients with asthma is much higher compared with the general population, and the trigger factor for this is unknown. We report a case of a 19-year-old male with a background of severe asthma who presented with eosinophilic lung infiltration after viral infection, which progressed to clinical EGPA. The diagnosis of EGPA was supported by an initial clinical presentation of recurrent cough and wheezing accompanied by a red rash, followed by peripheral eosinophilia, a high eosinophil percentage in bronchoalveolar lavage fluid (BALF), and migratory pulmonary eosinophilic infiltrates. Lung biopsy showed blood vessels with extravascular eosinophils. The patient responded well to high-dose glucocorticoids and cyclophosphamide, and symptoms and biochemical markers improved. Our literature review identified few reports on the triggers of EGPA, which highlights that viral infection may be a risk factor for asthma that progresses to EGPA.
Kombinasi Ekstrak Etanol 96% Daun Teh (Camellia sinensis (L.) Kuntze) dan Daun Yakon (Smallanthus sonchifolius) sebagai Penghambat Enzim ?-glukosidase
Authors: Sulastri Lilik , Hidayat Rohmat , Citroreksoko Padmono , Abdillah Syamsudin , Simanjuntak Partomuan
Published: February 2022

Diabetes mellitus is a degenerative disease in the form of metabolic disorders characterized by increased blood glucose levels and impaired insulin metabolism. Yakon leaves and tea leaves contain phenolic compounds which have ?-glucosidase inhibiting activity. The aims of this study was to determine the inhibitory activity of the ?-glucosidase enzyme from tea leaf and yakon leaf extracts and the combination of the two plants. Extraction of the active compounds contained in tea leaves and yakon leaves was carried out by graded maceration method using n-hexane, ethyl acetate, 96% ethanol and water as solvents (using the decoction method). Phytochemical analysis of 96% ethanol extract of tea leaves and yakon leaves contained alkaloids, flavonoids, tannins, saponins, triterpenoids/steroids and phenols. The results of testing the inhibitory activity of the -glucosidase enzyme showed that the IC50 values ??for 96% ethanol extract of tea leaves and yakon leaves were 22.31 and 19.70 ppm, respectively. Combination of 96% ethanol extract of tea leaves and yakon leaves in a ratio of 1:1; 1:3; 3:1 obtained IC50 of 64.73 ppm respectively; 7.34 ppm, and 11.03 ppm.
Skrinning Aktivitas Antimikroba Ekstrak Etanol Daun Mekai (Albertisia sp.)
Authors: Incau Nur Aini Buring , Almeida Maria , Indriyanti Niken
Published: February 2022

Albertisia sp. is a plant used as eye medicine because to infection of the eye or eyelid tract by the Dayak population in Malinau Regency, North Kalimantan. This study aims to determine whether the extract of mekai leaf has antimicrobial activity as well as activity as an antibacterial or antifungal. The method that was applied this study is extraction with a maceration using 96% ethanol, followed by phytochemical analysis. The agar diffusion technique was used to test the antibacterial activity by measuring the diameter of the inhibition zone at of various extract concentrations. According to the findings, mekai leaves contain secondary metabolites such as flavonoids, alkaloids, steroids, saponins, and phenolics. In the antimicrobial test results, the ethanolic extract of mekai leaf showed activity than M.furfur has a 11,52 ± 7,97 mm, A.niger has a of 10,66 ± 1,36 mm and C.albicans has a 6,31 ± 7,04 mm. Ethanolic extracts of mekai leaf show activity than E.coli 1,59 ± 3,16 mm, P.acnes 2,45 ± 4,55 mm, S.thypii 1,69 ± 3,07 mm, and V.cholerae 1,94 ± 4,21 mm. From this study it was said that the ethanolic extract of mekai leaves might be developed as an antifungal rather than as an antibacterial.
Kajian Efektivitas Pengobatan pada Pasien Stroke Iskemik di Instalasi Rawat Inap RSUD Nunukan
Authors: Tahir Rida Wahda Maulida , Rija’i Hifdzur Rashif , Indriyanti Niken
Published: February 2022

Ischemic stroke occurs due to obstruction of the blood vessels that supply the brain. Obstruction occurs due to increased fat lining the blood vessels or atherosclerosis. Atherosclerosis will cause cerebral thrombosis and cerebral embolism. This study aims to examine effectiveness of the use of drugs in ischemic stroke patients hospitalization at Nunukan Hospital. This study is a non-experimental study with a descriptive analysis design using medical record data collected retrospectively and the number of samples in this study was 70 patients. The sample selection of this research was using purposive sampling technique. The results showed tthe highest characteristics of ischemic stroke patients by gender were male (54.29%), based on age group 45-65 years (64.29%), based on diagnoses with comorbidities (64.70%), and the length of treatment the most occurred in 5-10 days (72.55%). The most used drugs single therapy for ischemic stroke are antiplatelet drugs, namely aspirin (28.57%) and the most used combination therapy is piracetam and citicoline (50%). The most frequent drug interactions were aspirin and clopidogrel (48.57%). While the accuracy of drug use includes the right indication (100%), the right drug (94.29%), the right dose (97.14%), and the right frequency (97.14%). Thus, it was concluded that the treatment of ischemic stroke at the inpatient installation the Nunukan General Hospital was effective.
Formulasi dan Evaluasi Nutrasetikal Gummy Candy dari Perasan Daun Kelakai (Stenochlaena Palustris (Burm.F.) Bedd)
Authors: Asdini Winiaksa Tri , Arifian Hanggara , Mita Nur , Rusli Rolan
Published: February 2022

Kelakai leaf (Stenochlaena palustris (Burm.F.) Bedd) is a typical plant of East Kalimantan with high iron content which can overcome anemia. The juice of anchovies was formulated into a nutraceutical gummy candy preparation using the Simplex Lattice Design (SLD) method. The results showed that the juice of anise leaves could be used as a gummy candy preparation with an evaluation results that meet the standard with a juice concentration of 9%, pH 5.4, chewy texture, elastic, strawberry essence aroma, sour taste, and brownish yellow color, 11.52% water content, and 2.30% ash content.
Kajian Literatur: Aktivitas Antioksidan Ekstrak Tanaman Cempedak (Artocarpus champeden Spreng)
Authors: Rahmawati Aulia Alfath , Ardana Mirhansyah , Sastyarina Yurika
Published: February 2022

Antioxidants are compounds that can counteract free radicals. One of the plants that have antioxidant activity is cempedak, because cempedak contains flavonoids compounds. This writing aims to determine the antioxidant activity of cempedak plants based on a review of several literatures. The method of writing a literature review uses a journal search from Google Scholar. Based on the literature review that has been carried out, the leaves and bark of cempedak have antioxidant activity. Based on the literature review of antioxidant activity of cempedak, methanol extract of stem bark had antioxidant activity of 100,26 ppm, leaf methanol extract 8,88 ppm, leaf ethanol extract 52,7706 ppm, leaf ethyl acetate fraction 4,282 ppm. The part of the cempedak plant that has the highest antioxidant activity is found in the leaves with the ethyl acetate fraction which shows an IC50 value of 4,282 ppm. Based on the IC50 value obtained, the ethyl acetate fraction of cempedak leaves has a very strong antioxidant activity because the IC50 is below 50 ppm.
Literature Review: Bahan Alam yang Berpotensi sebagai Antidiabetes
Authors: Novalinda Novalinda , Priastomo Mukti , Rijai Laode
Published: February 2022

Antidiabetes is a treatment that is currently much needed for diabetics, because the cost of treatment is getting higher, so it is recommended to use herbs as an alternative treatment. This study aims to determine natural ingredients that have the potential as antidiabetic. The method used is a systematic review by collecting, analyzing and summarizing 25 journals with the publication year 2016-2021 with keywords namely Antidiabetes, Natural Ingredients, and In Vivo. The results of the journal analysis are Beluntas leaves 0.9 mg/20 gBW, Kecombrang leaves 100 mg/kgBW, Keji Beling leaves 300 mg/kgBW, Kembang Bulan leaves 5.14 ml/200gBW, Kenikir leaves 1400 mg/200gBW, Mango leaves 105 mg /kgBW, Pucuk Merah leaves 100 g/kgBW, Rambutan leaves 50 mg/kgBW, Sambiloto leaves 40 mg/kgBW, Breadfruit leaves 600 mg/kgBW, Avocado seeds 150 mg/kgBW, Kebiul seeds 51mg/20gBW, Green Coffee Beans Arabica 400 mg/kgBW, Dates seeds 10 mL/day, Pumpkin seeds 720 mg/kgBW, Okra seeds 5,46 mg/gBW, Areca seeds 750 mg/kgBW, Buni bark 200 mg/kgBW, Faloak bark 150 mg /kgBW, Surian bark 150 mg/kgBW, Bilimbi fruit 750 mg/kgBW, Purple Sweet Potato fruit 150 mg/kgBW, Papaya flower 200 mg/kgBW, Pineapple peel 250 mg/kgBW and Black Garlic tuber 300 mg/kgBW with this optimal dose can reduce blood glucose levels.
Kajian Interaksi Obat Pasien Gagal Ginjal Kronis Di Instalasi Rawat Inap Rumah Sakit Samarinda Medika Citra
Authors: Hanyaq Angelina Theodora , Ramadhan Adam M. , Samsul Erwin
Published: February 2022

Patients with chronic kidney failure generally have comorbidities that cause the treatment of chronic kidney failure to be complex so that the number of drugs received by patients increases. The number of drugs consumed by the patient will increase the potential for drug interactions. The purpose of this study was to determine the characteristics, treatment patterns and potential drug interactions of patients with chronic kidney failure at Samarinda Medika Citra Hospital. The research method used is a non-experimental (observational) descriptive study with a retrospective approach. Data collection was carried out based on the medical record sheet of Chronic Kidney Failure patients in the inpatient room at Samarinda Medika Citra Hospital and obtained 59 patients. The results of the study of characteristic data based on age with the highest percentage in the elderly as much as 52.54%, based on gender, the highest percentage of sex was in the male sex, namely 50.85% and female as much as 49.15%. The most common comorbidities was anemia 50.84%. The most use of drug class is combination of 4 therapies with Antihypertensive + Supplement, Vitamin, Mineral + Antiulcer + Antiemetic group as much as 79.66%. The most common potential drug interactions found was the interaction of ranitidine with calos as much as 35.59% with minor severity.
Prácticas de Educación Comunitaria Crítica de la Universidad Surcolombiana en el marco de la Extensión Universitaria
Authors: Medina-Medina Nicolás
Published: February 2022

En el presente trabajo se realiza una aproximación interpretativa a las prácticas de educación comunitaria crítica de la extensión universitaria de la Universidad Surcolombiana, con base en los proyectos de Alfabetización del Pato Guayabero y el Macroproyecto DESCA; en el marco socio-histórico, contextualizado, situado y plural. Se reconocen las tensiones entre las posturas de la extensión universitaria y los contenidos de los proyectos en mención. Y, finalmente, se identifican seis prácticas de educación comunitaria crítica por sus saberes prácticos, sentires y materialidades.
Turismo y vida cotidiana: un enfoque complejo desde espacio-tiempo
Authors:   Universidad de la República (Uruguay), Campodónico Rossana , Chalar Luis ,   Universidad de la República (Uruguay)
Published: February 2022

This essay delves into the approach of the continuous distancing /rapprochement between daily life and tourism, important components of tourism theory, emphasizing the spacetime dimension, since it is understood that, given its centrality, they deserve further reflection. Specifically, an attempt will be made to answer the question: what characteristics does the VC/tourism/mobility trilogy present from the perspective of the space-time binomial and what can it imply in tourism? Among the results obtained, it is highlighted that the wide-range variables are enhanced in their combination and even more so if they intersect with different values at the level of individuals, groups of actors, as well as for tourism products and destinations.