bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Dimensi Psychological Well-Being Untuk Pengurangan Risiko Gangguan Depresi
Authors: Distina Primalita Putri
Published: September 2019

Depression has become one of the most common psychological disorders and causes health and disability problems worldwide. Many cases of suicide are caused by depression disorder. In Indonesia, the prevalence of depressive disorder is relatively high and occurs in all age ranges. Many factors cause depression disorder; one of them is stress. Stress which is not managed properly can cause several problems such as, low moods, feelings of irritability, sleep disturbances, and changes in cognitive abilities such as reduced concentration. These symptoms can be one of the risk factors for depression. One approach in psychology related to mental health problems is positive psychology. Psychological well-being is a construct of positive psychology that is often used as a form of intervention that focuses on human development. Based on some research results, psychological well-being related to a mental health problem, including depression. The dimensions in psychological well-being are self-acceptance, positive relations with others, autonomy, environmental mastery, purpose in life, and personal growth also have a positive role in mental health. By developing the dimensions of psychological well-being in life, it can be a way to reduce the risk of depression.
Eksistensi Komisi Penyiaran Indonesia Daerah (KPID) dalam Memperkuat Sistem Pengawasan Lembaga Penyiaran dan Materi Siaran
Authors: Ansori Muslim
Published: September 2019

Entering the era of digital revolutionary guards head general yahya at the time of this where do information can be we simply get for had such a closeness to local revenue for example through hp us to our personal. All the information can be accessed 've gone through lots of social media electronic. By how easily be run as soon as information program needs to be in can keep looking at whether the contents of the information in the table containing news of the population of that is less appropriate or was not appropriate to be broadcast and publish through the medium of such as television, radio and soon.Because of the law of information, the public which had bought have arranged what was set before them based on the information in a manner worthy of getting by the community in accordance with legislative regulations. Be launched since many broadcasting hearing with the house commission Indonesia the regions where they are into the arm of the state that rules and regulates all it comes to dealing with be launched since many broadcasting ethics. With growing information was not appropriate these changes in the future by the community this certainly shall be the responsibility of office KPID in protecting every station on television responds by sending out the radio to a press statement on the great commission nor related to in order to keep it hold fast regulated in the law
FENOMENA DAKWAH RADIKAL
Authors: Basri Basri
Published: September 2019

This article is focused on a description of how a group of academicians deals with radicalism in Islamic preaching (dakwa). The main problem is basically related to shifting paradigm in conveying religious message. The paradigm emerges in form of fundamentalism, extremism, radicalism and disappearance of belief and tolerance towards other people of different religious adherences.Some models and approaches of dakwa exercised by Islamic preachers are variousand therefore need preachers’ commitment, creativity, knowledge, skills, time allocation, etc. As preachers, academicians of STAIN SAS Babel should fulfill such requirements and qualifications. One of the models performed by STAIN’s academicians is dakwa bi al-hal (dakwa by practicing). The academicians write their religious views and understanding in books, journals and newspapers, attending scientific meetings and discussions, and involving in community empowerment programs. In addition, the academicians also use a phenomenology approach in which religious doctrine and understanding are clearly explained and comprehended to cope with social problems. By doing so, the academicians hope that people of Bangka Belitung could live peacefully and harmoniously whatever their religious belief and practice.
PARTAI ISLAM DI NEGARA MAYORITAS MUSLIM: STUDI PEMILU PERTAMA INDONESIA
Authors: Ali Jamilludin
Published: September 2019

The majority of Indonesian's populations are Moslems. The Islamic political elite saw the opportunity to take power by bringing the name of Islam to the political party. That are great opportunities because of the assumption that the majority of Moslems would vote for the Islamic party because Islamic party fighting for the benefit of Islam. However, history proves the Islamic party had never won in the general elections in Indonesia. Election of 1955 is regarded as the first democratic elections in Indonesia. It is fact. Although at that time the Moslems reach 90% of the total populations of Indonesia, the election results just put Islamic parties under nationalist party. The defeat of the Islamic party is caused by many things. Among these are the internal divisions in the Islamic party, is to promote party interests rather than Islam, and fierce resistance from nationalist and secular party.
Menelisik Sumbangan Islam Bagi Peradaban Modern
Authors: Noor Wahyudin
Published: September 2019

Islamic contributions to modern civilization, include: first, the contribution of Islam in modern science in a system of belief based on monotheism; secondly, in the political sphere, that Islam and democracy are essentially compatible, viable, and should be seen as a continuation or development of the Islamic "democratic" model; thirdly, for Islamic economics, starting from pioneering thinking to the continued to application of the system as part of the economic development of Islamic contributions to modern civilization; fourth, for social issues divided over human rights and women's status in Islam it opens up a golden opportunity for the Muslim community to radically revise the whole system of traditional thought toward a new system of thought, both in the Islamic horizon and the historical horizon of comparison; comparisons between Islam, Christianity, and Judaism, and specifically the comparison between Islam and modern Western achievements to the present day.
Pengunaan Bahasa Persuasi di Media Sosial dalam Berdakwah pada Akun Facebook ‘Yusuf Mansur (Official)’
Authors: Harista Eva
Published: September 2019

Dari masa ke masa dakwah mengalami perkembangan yang signifikan, terutama dakwah di media sosial yang dimanfaatkan oleh para Ustaz/Ustazah di Indonesia. Hal ini dapat terlihat dari jutawan follower yang mengikuti dan merespon setiap caption yang diunggah. Follower tersebut tidak hanya berasal dari Indonesia, tetapi juga tersebar di seluruh penjuru dunia. Salah satu Ustaz yang terkenal di Indonesia yang memiliki jutaan follower dalam media sosial yaitu Ustaz Yusuf Mansur.

Jenis penelitian ini adalah penelitian kualitatif. Adapun data dalam penelitian ini, penulis ambil pada akun Facebook ‘Yusuf Mansur (Official)’ yaitu kiriman yang diunggah pada Bulan Desember 2017 sebanyak 18 caption atau unggahan. Penulis mengkaji bahasa persuasi yang digunakan dalam unggahan tersebut.

Hasil penelitian menunjukkan bahwa Ustaz Yusuf Mansur menggunakan bahasa persuasi dalam setiap unggahannya. Ia mengajak para komunitasnya untuk melakukan kebaikan-kebaikan seperti yang diperintahkan Allah dan Rasul. Bahasa persuasi yang digunakan tidak selalu menggunakan bahasa Indonesia, tetapi juga bahasa daerah, sehingga terkesan santai dan sederhana, dan mudah dipahami. Bahasa persuasi yang digunakan bertujuan untuk mengajak, membujuk, menghimbau, menyarankan, menasihati, menawarkan, mempromosikan, menyindir, megingatkan, menginformasikan, dan meyakinkan para komunitasnya. Bahasa persuasi dakwah Ustaz Yusuf Mansur dapat mengubah cara berpikir, dapat memberikan manfaat, dapat menyejukkan hati, dapat memberikan pengaruh yang besar bagi kehidupan, dapat mengajak kepada kebaikan, dan memberikan perubahan bagi komunitasnya.
Hate Speech di Indonesia
Authors: Irawan Irawan
Published: September 2019

This article aims to explain hate speech in Indonesia and its solution. The theory used in this article is Critical Race Theory which is initiated by Richard Delgado and Jean Stefancic. This Critical Race Theory is also sustained by an Islamic perspective so as to be found the causes of hate speech and solutions that must be done. This paper concludes that: First, hate speech in Indonesia is verbally and non-verbally done which is delivered both directly and indirectly (social media). Second, hate speech in Indonesia causes social inequality, non-respectful attitudes, and national decline. Third, hate speech does not reflect the character of the Indonesian people who uphold ethics and the values of nationalism. Fourth, hate speech triggers violence and intolerance of religions, ethnicities, races, and groups. Hate speech must be jointly solved by government, religious leaders and society.
Representasi Nilai Dakwah dalam Iklan Susu Frisian Flag Gold Edisi Ramadhan 2017
Authors: Yulista Yera
Published: September 2019

Komunikasi adalah cara menyampaikan ide, konsep dari pikiran seseorang kepada orang lain untuk menghasilkan pengertian yang sama. Bentuk nyata dari penuangan ide itu sendiri dimunculkan lewat simbol-simbol (tanda) verbal atau non verbal sehingga dapat diterjemahkan maknanya oleh penerima pesan. Begitupun juga dengan tayangan iklan komersil  yang merupakan bentuk  komunikasi hasil dari konsep pemikiran pengiklan untuk disampaikan kepada penonton sehingga  menimbulkan dampak yang diinginkan pengiklan yakni selain produk yang ditawarkan menjadi dikenal namun dapat juga menarik pembelian produk itu sendiri. Agar pembelian produk dapat berhasil maka pengiklan harus merancang pesan dalam iklan seefektif mungkin dengan menuangkan konsep iklan yang kreatif sehingga memiliki posisi tawar diantara sekian banyak pesaing lainnya dengan produk yang sama misalkan dengan cara menampilkan keunggulan produk yang memiliki manfaat di dalam kehidupan manusia, salah satunya lewat  Iklan Susu Frisian Flag Gold. Iklan yang ditayangkan pada 2017 ini  mencoba mengemas kelebihan produk lewat settingan waktu bulan ramadhan yang sarat dengan nilai dakwah. Hal ini yang menarik perhatian peneliti untuk melihat Representasi Nilai Dakwah dalam Iklan Susu Frisian Flag Gold Edisi Ramadhan 2017 melalui pendekatan semiotika.
Konsep Kepribadian Al-Ghozali Untuk Mencapai Hasil Konseling yang Maksimal
Authors: Cholid Nurviyanti
Published: September 2019

Konseling merupakan proses bantuan berkesinambungan yang diberikan oleh konselor kepada konseli untuk memecahkan permasalah psikis atau kejiwaan konseli dengan memperhatikan landasan dan asas konseling. Di dalam melakukan proses konseling seorang konselor perlu memahami dulu teori kepribadian dari berbagai tokoh yang mengupas tentang teori kepribadian seperti al-Ghazali agar hasil yang didapat dari proses konseling dapat tercapai dengan maksimal. Dalam tulisan ini penulis mengurai kan tentang konsep kepribadian al-Ghazali sebagai bahan pertimbangan konselor dalam memahami kepribadian individu untuk mempermudah proses konseling.  Konsep kepribadian menurut pemikiran al-Ghazali seperti; hakekat manusia, dorongan dan emosi, struktur jiwa, tipologi kualitas insani, dan metode Perbaikan Akhlak (Konseling). Dari keseluruhan konsep kepribadian al-Ghazali tersebut, yang menjadi perhatian penuh oleh seorang konselor agar hasil konseling maksimal adalah dalam pengaplikasian metode perbaikan akhlak seperti metode taat syariat, metode pengembangan diri dan metode kesufian.
Tekstur Yoghurt Susu Kambing dengan Perbedaan Jenis Starter dan Lama Fermentasi
Authors: Sujono Sujono , Rofat Mochamad Rizal Ali , Kusuma Hendra , Khotimah Khusnul
Published: September 2019

One of the products of the Campus Intellectual Product Business Development Program (PPUPIK) is goat milk yoghurt, yoghurt itself is a drink made from fermented milk by lactic acid bacteria which is controlled. Yoghurt texture determines the tastes of consumers. Therefore it is necessary to study the texture of yoghurt with different types of starters and length of fermentation. This is to obtain yoghurt with maximum nutritional quality and a soft, thick texture to meet consumer tastes. The process of making yoghurt with fermentation time (6, 12, 18 and 24) hours with 37�C temperature and the type of starter bacteria (Streptococcus thermophillus, Lactobacillus bulgaricus and combinations), so that there were 12 treatments and repeated three times. The parameters observed by panellists are texture. The texture analysis of yoghurt was analyzed by de Garmo to find out the most appropriate treatment and much interest among panellists. Panellists favoured the de Garmo test results for 24-hour fermentation using the Lactobacillus bulgaricus bacteria with the highest texture product value of 2.10 (regular thick yoghurt).
Pembuatan Teh Bawang Dayak dan Manfaatnya Bagi Kader Pusat Kesehatan Masyarakat Harapan Baru Samarinda Seberang
Authors: Setyawan Annaas Budi , Budiman Arief , Septiawan Taufik
Published: September 2019

The community service activity was attended by cadres of Harapan Baru Community Health Center (Puskesmas) Samarinda Seberang who participated at the bawang dayak tea making program from the beginning to the end of the event, besides that in this activity also provided health education to the cadres about high blood pressure and even diabetes. This activity has the primary purpose of inviting Puskesmas cadres to utilize natural plant products bawang dayak, which can be processed into tea and can be taken for health benefits and have economic value. In using this bawang dayak plant, it needs proper processing so that the content is not reduced. The first step is to cut roots and leaves from bawang dayak, then wash them in running water, then slice them in a slice and then dry them, before finally storing them in airtight containers. Utilization of bawang dayak which are then processed into tea, this means encouraging the use of Borneo's unique plants into an alternative source of health and the ability to handle these plants into a product means increasing economic opportunities to contribute to solving social problems.
Key Issues for FDI Policy Re-formulation in Vietnam
Authors: Kenichi Ohno , Le Ha Thanh
Published: September 2019

This paper offers an overview of policy issues that should be considered in re-formulating Vietnam’s FDI policy orientation and structure. At first, three basic issues of definition, positive and negative impacts, and the dynamic nature of FDI policy are reviewed. Following that, FDI performance and eight key issues relevant to Vietnam are discussed in turn, which consist of (i) policy consistency; (ii) operational effectiveness; (iii) screening and post-investment follow-up; (iv) FDI marketing; (v) priority and restricted sectors; (vi) FDI-local firm linkage; (vii) consistency with international rules; and (viii) decentralized administration. These eight issues range from procedural matters on the ground to overall policy consistency, from maximizing developmental efforts to minimizing conflicts and problems. They are presented as a comprehensive checklist for FDI policy design and implementation.
Using Accounting Ratios in Predicting Financial Distress: An Empirical Investigation in the Vietnam Stock Market
Authors: Vo Xuan Vinh
Published: September 2019

Financial distress prediction is an important and practical research topic for many stakeholders and has attracted extensive studies over the past decades. This paper investigates the challenging issue of financial distress in Vietnam by distinguishing “healthy” companies from “financially distressed” companies using a data sample of firms listed on the Ho Chi Minh City Stock Exchange. Employing the logistic regression model to predict financial distress with a unique data set, we characterize the determinants of financial distress in terms of firm accounting and financial ratios over the period from 2007 to 2012. The results indicate that financial ratios can be employed as an early warning of financial distress as financial ratios are significantly correlated with the probability of firm financial distress.
Above-Average Debt Ratio and the Relationship with Return on Equity: The Case of the Vietnamese Listed Seafood Enterprises
Authors: Nguyen Thanh Lan , Phan Hong Mai
Published: September 2019

Many studies have presented the relationship between the leverage of firms and return on equity (ROE) in order to analyze how significant leverage has influence on the ROE of enterprises. Exploring the data set from financial statements and annual reports of the Vietnamese listed seafood enterprises from 2009 to 2013, the paper aims to examine the determinants of these firms having a greater debt ratio than the average of the industry. In addition, the relationship between ROE and a firm’s leverage is analyzed by applying a fixed-effects regression. It can be found that firms having an above-average debt ratio have a lower ROE than their counterparts by 50.94%.
Trust and Truth inShutter Island
Authors: Laba Suzanne Cataldi
Published: September 2019

This article examines questions of trust in cinema through the lens of Shutter Island (Martin Scorsese, 2010). With its self-referential allusion to the mechanical “eye” of a camera, a stage-managed fantasy embedded within its plot and image of a dark lighthouse, Shutter Island explores its spectators' and its own cinematic sense of suspicion. The plot revolves around a protagonist who has locked himself out of certain memories and into a fantasy world. The article links pathological and therapeutic aspects of trust with interpersonal and institutional trust issues in ways that blur distinctions between trusting others and trusting oneself, and shows how reliant each is on the other. Construing trust as a type of participant attitude and highlighting techniques used to render it cinematically, the article tracks its emergence and erosion, both in terms of the diegesis and its bearing on film spectatorship. As a post-classical commentary on film-making, Shutter Island is viewed as intricately exemplifying what Robert Sinnerbrink (2016) describes as an action-driven film with “a highly reflective consciousness of cinematic spectatorship” (p. 70), as well as what Thomas Elsaesser (2009) describes as a “mind-game film”. To make sense of its ending, which may strike viewers as baffling and unnerving, and show how the protagonist's seemingly irrational decision is part of its film-philosophical point, traumatic disturbances in subjectivity and “monstrosities” depicted in the film are linked to Jean Epstein's notion of “something monstrous” in cinematic imagery. The protagonist's deliberately chosen fate is interpreted as a reparative gesture, expressing a desire for psychological healing and a way of helping him to marshal and recover a semblance of moral order and integrity under demoralizing circumstances.
Quantification of Bolt Tension by Surface Acoustic Waves: An Experimentally Verified Simulation Study
Authors: Alhazmi Hani , Guldiken Rasim
Published: September 2019

Quantifying bolt tension and ensuring that bolts are appropriately tightened for large-scale civil infrastructures are crucial. This study investigated the feasibility of employing the surface acoustic wave (SAW) for quantifying the bolt tension via finite element modeling. The central hypothesis is that the real area of contact in a bolted joint increases as the tension or preload is increased, causing an acoustical signature change. The experimentally verified 3-D simulations were carried out in two steps: A preload was first applied to the bolt body to simulate the realistic behavior of bolted joint; and the SAW propagation was then excited on the top surface of the plate to reflect from the bolted joint. The bolt tension value was varied between 4 and 24 kN (properly tightened bolt) in the steps of 4 kN to study the effect of the bolt tension. The results indicate an increased reflected wave amplitude and a gradual phase shift, up to 0.5 µs, as the bolt tension increased. Furthermore, the result shows that the distance between the first reflected wave and the source becomes shorter as the preload increases, as hypothesized. A 1.9 mm difference in the distance between the maximum and minimum preload was observed. As part of this study, the simulation results were also compared with the experimental results, and a good agreement between the simulation and experiments was demonstrated.
Relationships between Plant Architecture Traits and Cotton Yield within the Plant Height Range of 80–120 cm Desired for Mechanical Harvesting in the Yellow River Valley of China
Authors: Yan Wei , Du Mingwei , Zhao Wenchao , Li Fang , Wang Xiangru , Eneji A. Egrinya , Yang Fuqiang , Huang Jian , Meng Lu , Qi Haikun , Xue Guojuan , Xu Dongyong , Tian Xiaoli , Li Zhaohu
Published: September 2019

Mechanical harvesting has become inevitable for cotton production in China due to the rising labor cost in the country. It usually requires a moderate plant height and compact plant architecture. Correlation and stepwise regression were employed to analyze databases of our 24 field experiments between 2010 and 2017 in Hebei Province. The purpose is to identify the relationships between plant architecture traits and seed cotton yield within natural plant height range (58.6–163.2 cm) or preferred plant height range (80–120 cm) for mechanical harvesting in the Yellow River Valley of China, and define some important factors affecting seed cotton yield. Under natural plant height range across all experiments, there was a significantly negative correlation (r = −0.452) between plant height and yield. On limited plant height range desired for mechanical harvesting, the degree of this negative correlation decreased to r = −0.366. The correlation of plant height with seed cotton yield varied greatly with year, cultivar, plant density and mepiquat chloride (MC) application. Moreover, stepwise regression analysis picked internode length of the 1st (generally including 1st–7th mainstem node from bottom), 2nd (8th–12th node) and 4th (above 17th node) mainstem section and the length of lower fruiting branch (LFB) as significant factors influencing seed cotton yield under plant height range of 80–120 cm. The results have implications for precise control of cotton plant architecture preferred for mechanized harvesting in China.
Genome-Wide Association Study for Reproductive Traits in a Duroc Pig Population
Authors: Zhang Zhe , Chen Zitao , Ye Shaopan , He Yingting , Huang Shuwen , Yuan Xiaolong , Chen Zanmou , Zhang Hao , Li Jiaqi
Published: September 2019

In the pig industry, reproductive traits constantly influence the production efficiency. To identify markers and candidate genes underlying porcine reproductive traits, a genome-wide association study (GWAS) was performed in a Duroc pig population. In total, 1067 pigs were genotyped using single-nucleotide polymorphism (SNP) chips, and four reproductive traits, including litter size at birth (LSB), litter weight at birth (LWB), litter size at weaning (LSW), and litter weight at weaning (LWW), were examined. The results showed that 20 potential SNPs reached the level of suggestive significance and were associated with these traits of interest. Several important candidate genes, including TXN2, KCNA1, ENSSSCG00000003546, ZDHHC18, MAP2K6, BICC1, FAM135B, EPHB2, SEMA4D, ST3GAL1, KCTD3, FAM110A, TMEM132D, TBX3, and FAM110A, were identified and might compose the underlying genetic architecture of porcine reproductive traits. These findings help to understand the genetic basis of porcine reproductive traits and provide important information for molecular breeding in pigs.
Inflammation and Reduced Parasympathetic Cardiac Modulation in Aortic-Valve Sclerosis
Authors: Echeverría Juan C. , Ávila-Vanzzini Nydia , Springall Rashidi , Torres-Arellano José M. , Toledo Andrea , Infante Oscar , Bojalil Rafael , Cossío Jorge , Fajardo Erika , Lerma Claudia
Published: September 2019

Aortic-valve sclerosis increases cardiovascular mortality risk and precedes aortic-valve stenosis, but its mechanisms are not well understood. The purpose of this study was to compare the cardiac autonomic modulation and inflammation markers between subjects with aortic-valve normal leaflets and subjects with aortic-valve sclerosis. According to 2-D transthoracic echocardiograms, 61 middle-aged volunteers without chronic or acute illnesses were classified in two groups: with no aortic-valve sclerosis (NAVS, N = 16) and with aortic-valve sclerosis (AVS, N = 45). An electrocardiogram at the supine position and active standing was collected to estimate heart rate variability (HRV) indices. A blood sample was obtained to quantify markers of inflammation. Compared to NAVS, AVS subjects showed higher levels of IL-6 (1619 ± 650 vs. 1169 ± 676 pg/mL, p = 0.044) as well as TNFα (370.8 ± 182.0 vs. 247.3 ± 188.2 pg/mL, p = 0.032), and larger low-frequency (LF) to high-frequency (HF) ratio during supine position (Ln(LF/HF) = 0.85 ± 0.85 vs. 0.11 ± 0.69, p = 0.003). Multiple logistic regression analysis showed that AVS was independently associated with LF/HF, TNFα and left ventricle mass index (p < 0.05). In conclusion, a significant reduction of the parasympathetic-driven cardiac modulation and low-grade inflammation occurs in aortic-valve sclerosis.
Simulative Investigation of the Radar Cross Section of Wind Turbines
Authors: Hegler Sebastian , Plettemeier Dirk
Published: September 2019

Wind-power generation is one of the fundamental sources of renewable energy. However, due to the increasing size of wind turbines, they cause unwanted interference with radar systems for civic protection, especially for on-shore locations. This paper presents parameter studies performed on different wind-turbine models, with a focus on differences of the aerodynamical shape of the rotor blades. Numerical simulation is employed to estimate the influence of different wind-turbine design parameters, with the aim of deriving strategies to minimize wind-turbine influence on radar systems for civic protection. Due to the complex nature of the aerodynamic shape of the blade, a general model cannot be derived from the studies. However, further steps to eventually achieve this goal are outlined.
Enhanced Exopolysaccharide Production by Lactobacillus rhamnosus in Co-Culture with Saccharomyces cerevisiae
Authors: Bertsch Annalisse , Roy Denis , LaPointe Gisèle
Published: September 2019

Lactobacillus strains are known to produce exopolysaccharides (EPS) with recognized health benefits (i.e. prebiotic and immunomodulation) but production is limited by low yields. Co-culture has been shown to improve metabolite productivity, particularly bacteriocins and EPS. Although lactic acid bacteria (LAB) and yeasts are found in several fermented products, the molecular mechanisms linked to the microbial interactions and their influences on EPS biosynthesis are unclear. The aim of the present study was to investigate the effect of co-culture on EPS production by three Lactobacillus rhamnosus strains (ATCC 9595, R0011, and RW-9595M) in association with Saccharomyces cerevisiae. Fermentation, in both mono and co-culture, was carried out and the expression of key LAB genes was monitored. After 48 h, results revealed that EPS production was enhanced by 39%, 49%, and 42% in co-culture for R0011, ATCC 9595, and RW-9595M, respectively. Each strain showed distinctive gene expression profiles. For a higher EPS production, higher EPS operon expression levels were observed for RW-9595M in co-culture. The construction of gene co-expression networks revealed common correlations between the expression of genes related to the EPS operons, sugar metabolism, and stress during EPS production and microbial growth for the three strains. Our findings provide insight into the positive influence of inter-kingdom interactions in stimulating EPS biosynthesis, representing progress toward the development of a bio-ingredient with broad industrial applications.
Centrifugally Spun α-Fe2O3/TiO2/Carbon Composite Fibers as Anode Materials for Lithium-Ion Batteries
Authors: Zuniga Luis , Gonzalez Gabriel , Orrostieta Chavez Roberto , Myers Jason C. , Lodge Timothy P. , Alcoutlabi Mataz
Published: September 2019

We report results on the electrochemical performance of flexible and binder-free α-Fe2O3/TiO2/carbon composite fiber anodes for lithium-ion batteries (LIBs). The composite fibers were produced via centrifugal spinning and subsequent thermal processing. The fibers were prepared from a precursor solution containing PVP/iron (III) acetylacetonate/titanium (IV) butoxide/ethanol/acetic acid followed by oxidation at 200 °C in air and then carbonization at 550 °C under flowing argon. The morphology and structure of the composite fibers were characterized using X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDS), X-ray photoelectron spectroscopy (XPS), and thermogravimetric analysis (TGA). These ternary composite fiber anodes showed an improved electrochemical performance compared to the pristine TiO2/C and α-Fe2O3/C composite fiber electrodes. The α-Fe2O3/TiO2/C composite fibers also showed a superior cycling performance with a specific capacity of 340 mAh g−1 after 100 cycles at a current density of 100 mA g−1, compared to 61 mAh g−1 and 121 mAh g−1 for TiO2/C and α-Fe2O3/C composite electrodes, respectively. The improved electrochemical performance and the simple processing of these metal oxide/carbon composite fibers make them promising candidates for the next generation and cost-effective flexible binder-free anodes for LIBs.
MFCSNet: Multi-Scale Deep Features Fusion and Cost-Sensitive Loss Function Based Segmentation Network for Remote Sensing Images
Authors: Wang Ende , Jiang Yanmei , Li Yong , Yang Jingchao , Ren Mengcheng , Zhang Qingchun
Published: September 2019

Semantic segmentation of remote sensing images is an important technique for spatial analysis and geocomputation. It has important applications in the fields of military reconnaissance, urban planning, resource utilization and environmental monitoring. In order to accurately perform semantic segmentation of remote sensing images, we proposed a novel multi-scale deep features fusion and cost-sensitive loss function based segmentation network, named MFCSNet. To acquire the information of different levels in remote sensing images, we design a multi-scale feature encoding and decoding structure, which can fuse the low-level and high-level semantic information. Then a max-pooling indices up-sampling structure is designed to improve the recognition rate of the object edge and location information in the remote sensing image. In addition, the cost-sensitive loss function is designed to improve the classification accuracy of objects with fewer samples. The penalty coefficient of misclassification is designed to improve the robustness of the network model, and the batch normalization layer is also added to make the network converge faster. The experimental results show that the classification performance of MFCSNet outperforms U-Net and SegNet in classification accuracy, object details and prediction consistency.
A Review of Deep Learning Based Speech Synthesis
Authors: Ning Yishuang , He Sheng , Wu Zhiyong , Xing Chunxiao , Zhang Liang-Jie
Published: September 2019

Speech synthesis, also known as text-to-speech (TTS), has attracted increasingly more attention. Recent advances on speech synthesis are overwhelmingly contributed by deep learning or even end-to-end techniques which have been utilized to enhance a wide range of application scenarios such as intelligent speech interaction, chatbot or conversational artificial intelligence (AI). For speech synthesis, deep learning based techniques can leverage a large scale of  pairs to learn effective feature representations to bridge the gap between text and speech, thus better characterizing the properties of events. To better understand the research dynamics in the speech synthesis field, this paper firstly introduces the traditional speech synthesis methods and highlights the importance of the acoustic modeling from the composition of the statistical parametric speech synthesis (SPSS) system. It then gives an overview of the advances on deep learning based speech synthesis, including the end-to-end approaches which have achieved start-of-the-art performance in recent years. Finally, it discusses the problems of the deep learning methods for speech synthesis, and also points out some appealing research directions that can bring the speech synthesis research into a new frontier.
The Gallery as a Location for Research-Informed Practice and Critical Reflection
Authors: Pepper Andrew
Published: September 2019

Creative holography could still be considered a fringe medium or methodology, compared to mainstream art activities. Unsurprisingly, work using this technology continues to be shown together with other holographic works. This paper examines the merits of exhibiting such works alongside other media. It also explores how this can contribute to the development of a personal critical framework and a broader analytical discourse about creative holography. The perceived limitations of showing holograms in a “gallery ghetto” are explored using early critical art reviews about these group exhibitions. An international exhibition, which toured the United Kingdom (UK) and Australia, is used as a framework to expand the discussion. These exhibitions include examples of the author’s holographic work and those of artists working with other (non-holographic) media and approaches. The touring exhibition as a transient, research-informed process is investigated, as is its impact on the critical development of work using holography as a valid medium, approach, and methodology in the creative arts.
Tissue-Derived Biological Particles Restore Cornea Properties in an Enzyme-Mediated Corneal Ectatic Model
Authors: Yin Hongbo , Wang Xiaokun , Majumdar Shoumyo , Sohn Jeeyeon , Kim Byung-Jin , Stark Walter , Elisseeff Jennifer H.
Published: September 2019

Purpose: To investigate the impact of tissue derived biological particles on enzyme-mediated weakened corneas. Methods: Rabbit corneas were treated with enzymes to create an ex vivo ectatic model that simulated representative characteristics of keratoconus (KC). Porcine cornea, cartilage, and lymph node tissues were processed to remove most cellular components and cryomilled into microparticles. The KC corneas were cultured in medium containing the tissue-derived biological particles (TDP) overnight. The mechanical, thermal, ultrastructural changes, and gene expressions of corneal stromal cells were characterized to evaluate the effects of the TDP treatment. Results: The enzyme treatment significantly reduced corneal mechanics and thermal stability, and also disrupted the extracellular matrix ultrastructure. After culturing with TDP medium, the Young’s modulus of the modeled KC corneas increased by ~50%, comparable to normal cornea controls. Similarly, the thermal denaturation temperature of the corneas was restored. These findings also corresponded to a significant increase in collagen fibril density after TDP treatment. Furthermore, corneas cultured in TDP medium significantly downregulated expression of the pro-inflammatory gene Tnfα, and restored the expression of the key keratocyte markers Aldh, keratocan, and biglycan. Conclusions: Tissue-derived biological particles reinforce mechanical and thermal properties of corneal tissue in an ex vivo model of KC. Through this study, we demonstrate and characterize the previously unexplored impact of tissue-derived biological scaffolds on corneal biomechanics, thermal stability, and gene expression, presenting a potential new therapy for ocular disease.
MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex
Authors: Slavata Lukáš , Chmelík Josef , Kavan Daniel , Filandrová Růžena , Fiala Jan , Rosůlek Michal , Mrázek Hynek , Kukačka Zdeněk , Vališ Karel , Man Petr , Miller Michael , McIntyre William , Fabris Daniele , Novák Petr
Published: September 2019

The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level. We implemented a concerted structural proteomics approach, which combined hydrogen-deuterium exchange (HDX), quantitative protein-protein and protein-nucleic acid cross-linking (XL), and homology analysis, to model the structure of the complex between the full-length DNA binding domain (DBD) of Forkhead box protein O4 (FOXO4) and its DNA binding element (DBE). The results confirmed that FOXO4-DBD assumes the characteristic forkhead topology shared by these types of transcription factors, but its binding mode differs significantly from those of other members of the family. The results showed that the binding interaction stabilized regions that were rather flexible and disordered in the unbound form. Surprisingly, the conformational effects were not limited only to the interface between bound components, but extended also to distal regions that may be essential to recruiting additional factors to the transcription machinery. In addition to providing valuable new insights into the binding mechanism, this project provided an excellent evaluation of the merits of structural proteomics approaches in the investigation of systems that are not directly amenable to traditional high-resolution techniques.
Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma
Authors: Jamnongkan Wassana , Lebrilla Carlito B. , Barboza Mariana , Techasen Anchalee , Loilome Watcharin , Sithithaworn Paiboon , Khuntikeo Narong , Pairojkul Chawalit , Chamadol Nittaya , Thanan Raynoo , Yongvanit Puangrat
Published: September 2019

Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups is urgently needed for the control of CCA in this region. Periductal fibrosis (PDF) induced by chronic inflammation of bile ducts is known as a pre-neoplastic lesion of CCA. We aimed to identify the serum CCA and PDF biomarkers using mass spectrometry (UPLC-ESI-QqQ) with multiple reaction mode (MRM) analysis. Here, serum levels of serotransferrin glycoforms at the glycopeptide level were measured in the sera of CCA (n = 100), PDF (n = 50), and healthy control (n = 100) subjects. The results indicated that serotransferrin peptide levels were generally the same between the control and PDF groups, whereas CCA patients had reduced levels. Moreover, 56 serotransferrin glycoforms were detected, with nine increased in CCA compared to control subjects. Among them, the serum levels of four glycoforms were increased in PDF and CCA patients compared to control subjects. In particular, highly sialylated multi-branched glycans of serotransferrin serum were significantly correlated with poor prognosis and tumor stage in CCA patients. Taken together, these glycoforms could be used as risk biomarkers and prognosis and diagnosis markers of CCA.
Monosodium Glutamate (MSG) Renders Alkalinizing Properties and Its Urinary Metabolic Markers of MSG Consumption in Rats
Authors: Nahok Kanokwan , Li Jia V. , Phetcharaburanin Jutarop , Abdul Hasina , Wongkham Chaisiri , Thanan Raynoo , Silsirivanit Atit , Anutrakulchai Sirirat , Selmi Carlo , Cha’on Ubon
Published: September 2019

Monosodium glutamate (MSG) is widely used as a flavor enhancer and its effects on human health are still debated. We aimed to investigate whether MSG can act as alkalinizing agent in murine models and if its metabolites are biomarkers of MSG consumption. For this purpose, adult male Wistar rats were given water added with 1 g% MSG or three types of control water, including sodium chloride (NaCl) and sodium bicarbonate (NaHCO3). At 14 days, urinary pH, electrolytes, urinary metabolites and ion-exchanger gene expression were determined. The results revealed that MSG-treated rats had significantly more alkaline urine and higher levels of urinary sodium and bicarbonate similar to NaHCO3 controls. These changes correlated with a lower expression of ion-exchanger genes, namely, CAII, NBC1, and AE1, which are involved in bicarbonate kidney reabsorption. The urinary metabolic profiles also revealed similar patterns for the MSG and NaHCO3 groups. In conclusion, MSG exhibits similar properties to NaHCO3, an alkalinizing agent, with regard to inducing alkaline urine, reducing bicarbonate kidney reabsorption, and generating a specific urinary metabolic pattern. We believe that these observations will be useful to further study the MSG effects in humans.
The Link That Binds: The Linker of Hsp70 as a Helm of the Protein’s Function
Authors: Chakafana Graham , Zininga Tawanda , Shonhai Addmore
Published: September 2019

The heat shock 70 (Hsp70) family of molecular chaperones plays a central role in maintaining cellular proteostasis. Structurally, Hsp70s are composed of an N-terminal nucleotide binding domain (NBD) which exhibits ATPase activity, and a C-terminal substrate binding domain (SBD). The binding of ATP at the NBD and its subsequent hydrolysis influences the substrate binding affinity of the SBD through allostery. Similarly, peptide binding at the C-terminal SBD stimulates ATP hydrolysis by the N-terminal NBD. Interdomain communication between the NBD and SBD is facilitated by a conserved linker segment. Hsp70s form two main subgroups. Canonical Hsp70 members generally suppress protein aggregation and are also capable of refolding misfolded proteins. Hsp110 members are characterized by an extended lid segment and their function tends to be largely restricted to suppression of protein aggregation. In addition, the latter serve as nucleotide exchange factors (NEFs) of canonical Hsp70s. The linker of the Hsp110 family is less conserved compared to that of the canonical Hsp70 group. In addition, the linker plays a crucial role in defining the functional features of these two groups of Hsp70. Generally, the linker of Hsp70 is quite small and varies in size from seven to thirteen residues. Due to its small size, any sequence variation that Hsp70 exhibits in this motif has a major and unique influence on the function of the protein. Based on sequence data, we observed that canonical Hsp70s possess a linker that is distinct from similar segments present in Hsp110 proteins. In addition, Hsp110 linker motifs from various genera are distinct suggesting that their unique features regulate the flexibility with which the NBD and SBD of these proteins communicate via allostery. The Hsp70 linker modulates various structure-function features of Hsp70 such as its global conformation, affinity for peptide substrate and interaction with co-chaperones. The current review discusses how the unique features of the Hsp70 linker accounts for the functional specialization of this group of molecular chaperones.
Molecular Docking of Isolated Alkaloids for Possible α-Glucosidase Inhibition
Authors: Rahman Noor , Muhammad Ijaz , Gul-E-Nayab  , Khan Haroon , Aschner Michael , Filosa Rosanna , Daglia Maria
Published: September 2019

Diabetes mellitus, one of the most common endocrine-metabolic disorders, has caused significant morbidity and mortality worldwide. To avoid sugar digestion and postprandial hyperglycemia, it is necessary to inhibit α-glucosidase, a digestive enzyme with an important role in carbohydrate digestion. The criteria for the selection of alkaloids are based on their in vitro and in vivo activities on glucose modulation. The current study assessed the bonding potential of isolated alkaloids with the targeted protein. For this purpose, the 3D structure of the target protein (α-glucosidase) was reproduced using MODELLER 9.20. The modeled 3D structure was then validated and confirmed by using the RAMPAGE, ERRAT, and Verify3D online servers. The molecular docking of 32 alkaloids reported as α-glucosidase inhibitors, along with reference compounds (acarbose and miglitol), was done through MOE-Dock applied in MOE software to predict the binding modes of these drug-like compounds. The results revealed that nummularine-R and vindoline possess striking interactions with active site residues of the target protein, and were analogous to reference ligands. In conclusion, the current study provided a computational background to the α-glucosidase inhibitors tested. This novel information should facilitate the development of new and effective therapeutic compounds for the treatment of diabetes mellitus.
Sample Size for Oxidative Stress and Inflammation When Treating Multiple Sclerosis with Interferon-β1a and Coenzyme Q10
Authors: Moccia Marcello , Capacchione Antonio , Lanzillo Roberta , Carbone Fortunata , Micillo Teresa , Matarese Giuseppe , Palladino Raffaele , Brescia Morra Vincenzo
Published: September 2019

Studying multiple sclerosis (MS) and its treatments requires the use of biomarkers for underlying pathological mechanisms. We aim to estimate the required sample size for detecting variations of biomarkers of inflammation and oxidative stress. This is a post-hoc analysis on 60 relapsing-remitting MS patients treated with Interferon-β1a and Coenzyme Q10 for 3 months in an open-label crossover design over 6 months. At baseline and at the 3 and 6-month visits, we measured markers of scavenging activity, oxidative damage, and inflammation in the peripheral blood (180 measurements). Variations of laboratory measures (treatment effect) were estimated using mixed-effect linear regression models (including age, gender, disease duration, baseline expanded disability status scale (EDSS), and the duration of Interferon-β1a treatment as covariates; creatinine was also included for uric acid analyses), and were used for sample size calculations. Hypothesizing a clinical trial aiming to detect a 70% effect in 3 months (power = 80% alpha-error = 5%), the sample size per treatment arm would be 1 for interleukin (IL)-3 and IL-5, 4 for IL-7 and IL-2R, 6 for IL-13, 14 for IL-6, 22 for IL-8, 23 for IL-4, 25 for activation-normal T cell expressed and secreted (RANTES), 26 for tumor necrosis factor (TNF)-α, 27 for IL-1β, and 29 for uric acid. Peripheral biomarkers of oxidative stress and inflammation could be used in proof-of-concept studies to quickly screen the mechanisms of action of MS treatments.
The Performance of Nickel and Nickel-Iron Catalysts Evaluated As Anodes in Anion Exchange Membrane Water Electrolysis
Authors: Cossar Emily , Oyarce Barnett Alejandro , Seland Frode , Baranova Elena A.
Published: September 2019

Anion exchange membrane water electrolysis (AEMWE) is an efficient, cost-effective solution to renewable energy storage. The process includes oxygen and hydrogen evolution reactions (OER and HER); the OER is kinetically unfavourable. Studies have shown that nickel (Ni)- iron (Fe) catalysts enhance activity towards OER, and cerium oxide (CeO2) supports have shown positive effects on catalytic performance. This study covers the preliminary evaluation of Ni, Ni90Fe10 (at%) and Ni90Fe10/CeO2 (50 wt%) nanoparticles (NPs), synthesized by chemical reduction, as OER catalysts in AEMWE using commercial membranes. Transmission electron microscopy (TEM) images of the Ni-based NPs indicate NPs roughly 4–6 nm in size. Three-electrode cell measurements indicate that Ni90Fe10 is the most active non-noble metal catalyst in 1 and 0.1 M KOH. AEMWE measurements of the anodes show cells achieving overall cell voltages between 1.85 and 1.90 V at 2 A cm−2 in 1 M KOH at 50 °C, which is comparable to the selected iridium-black reference catalyst. In 0.1 M KOH, the AEMWE cell containing Ni90Fe10 attained the lowest voltage of 1.99 V at 2 A cm−2. Electrochemical impedance spectroscopy (EIS) of the AEMWE cells using Ni90Fe10/CeO2 showed a higher ohmic resistance than all catalysts, indicating the need for support optimization.