bluuebunny/crossref_metadata_2025 huggingface dataset:
Nuove ricerche all’acropoli di Cuma. Il Santuario Inferiore (campagna 2023)
Authors: Fabiano Fiorello Di Bella  , Nicola Compagnone  , Giuseppe Costanzo  , Ciro Donisio  , Lucrezia Mastropietro  , Francesca Paleari
Published: September 2024

L’Università degli Studi della Campania ‘Luigi Vanvitelli’ e la Scuola Superiore Meridionale hanno avviato un nuovo progetto di ricerca sull’acropoli di Cuma che riguarda una parte della terrazza inferiore della collina. La prima campagna di scavo ha avuto luogo nei mesi di giugno, luglio e agosto 2023 in regime di convenzione triennale con il Parco Archeologico dei Campi Flegrei. Queste attività di ricerca e formazione avanzata hanno visto la partecipazione continua, per tutte le fasi della missione, di assegnisti e dottorandi della Scuola Superiore Meridionale, per un totale di una decina di partecipanti. L’area, a cui è stata attribuita la denominazione convenzionale di zona V, è situata a Nord del tempio grande, da ora in avanti Tempio Inferiore, e a Est della c.d. Cisterna Greca. Da qui si apre, inoltre, l’ingresso nord-ovest del Santuario Inferiore, che corrisponde a quello attuale e che conduce dalla via sacra direttamente alla fronte del tempio, costruito sul lato meridionale della terrazza.L’area è stata oggetto di trincee già a partire dal 1910 con le ricerche di Ettore Gabrici, delle quali manca purtroppo un’adeguata edizione. A partire dal taccuino di scavo, il settore settentrionale della terrazza risulta profondamente soggetto a sconvolgimenti e a massicci riempimenti di epoca ellenistica e romana, verificati anche nel corso delle nostre ricerche. Nel 1911 e nel 1916-1917, Vittorio Spinazzola sottopose l’area a lunghe campagne di sterro allo scopo di proseguire le indagini di Gabrici. Anche in questo caso manca una pubblicazione dei risultati e le uniche notizie in nostro possesso sono desumibili dai giornali di scavo...
Metaponto, Tavole Palatine. Cronaca e dati preliminari dalle campagne di scavo 2022-2023 della Scuola Superiore Meridionale
Authors: Carlo Rescigno  , Daniel P. Diffendale  , Federico Nomi  , Luca Salvaggio  , Ilaria Trafficante
Published: September 2024

Tra il 2022 e il 2023 le ricerche condotte dalla Scuola Superiore Meridionale nel santuario extraurbano di Hera a Metaponto, il cui tempio dorico è anche noto col nome di “Tavole Palatine”, hanno portato all’acquisizione di nuovi dati sulla storia insediativa del luogo tra la fine del VII sec. a.C. e l’epoca romano-imperiale. Gli scavi si sono concentrati su due aree. A nord del tempio dorico è stata riportata alla luce una struttura già indagata da Dinu Adamesteanu e da egli interpretata come muro di temenos. I materiali confermano che si tratta del primo recinto del santuario, precedente alla costruzione del tempio, forse caduto in disuso in seguito all’ampliamento dell’area in un momento di poco successivo alla fine del VI sec. a.C. e obliterato in epoca ellenistica. A sud del tempio, in un settore caratterizzato da un’anomalia di forma ovale sul manto erboso, le indagini hanno rivelato i resti di un’area votiva frequentata tra la fine del VII a.C. e la metà del secolo successivo, in seguito obliterata e intercettata da fosse votive scavate nel corso del VI sec. a.C. I depositi arcaici erano coperti da un accumulo di scaglie di arenaria riconducibile ad azioni di spoliazione dell’edificio templare o di altre strutture annesse al santuario in un’epoca compresa tra il II e il III sec. d.C.
Research conducted between 2022 and 2023 by the Scuola Superiore Meridionale in the extraurban sanctuary of Hera at Metaponto, the site of the Doric temple known as the “Tavole Palatine,” brought to light new information about the occupation history of the site between the end of the 7th century BCE and the Roman Imperial period. Excavation focused on two areas. The first, to the north of the temple, uncovered a structure previously investigated by Dinu Adamesteanu, who interpreted it as the wall of the temenos. The excavated material confirmed its identification as the earliest enclosure of the sanctuary, preceding the construction of the temple, possibly fallen into disuse following the expansion of the area just after the end of the 6th century BCE and obliterated in the Hellenistic period. The second excavation, to the south of the temple, focused on an area characterized by an oval-shaped anomaly visible in the vegetation. Here, investigations revealed the remains of a votive area in use between the end of the 7th and the middle of the 6th century BCE, put out of use and then disturbed by votive pits dug over the course of the 6th century. The Archaic deposits were covered by a fill of sandstone fragments resulting from the spoliation of the temple or of other structures in the sanctuary at some point between the 2nd and 3rd centuries CE.
Le campagne di scavo sull’acropoli di Cuma dell’Università degli Studi della Campania ‘Luigi Vanvitelli’ e della Scuola Superiore Meridionale
Authors: Carlo Rescigno
Published: September 2024

Si fornisce, in questa sezione, un primo resoconto degli scavi condotti dall’Università degli Studi della Campania ‘Luigi Vanvitelli’ – Dipartimento di Lettere e Beni Culturali e dalla Scuola Superiore Meridionale – Area Archeologia e Culture del Mediterraneo Antico sull’acropoli di Cuma nel periodo 2019-2023 a valle di una attività pluriennale avviata fin dal 2011. Le ricerche hanno riguardato nuove aree di indagine, un pianoro tra le due terrazze dell’acropoli, con i resti di una chiesa, e la parte settentrionale del Santuario Inferiore. 
This section provides an initial account of the excavations conducted by the University of Campania ‘Luigi Vanvitelli’ – Department of Letters and Cultural Heritage and the Scuola Superiore Meridionale – Area of ​​Archaeology and Cultures of the Ancient Mediterranean on the acropolis of Cumae in the period 2019-2023, following a multi-year activity started in 2011. The research involved new areas of investigation, a plateau between the two terraces of the acropolis, with the remains of a church, and the northern part of the Lower Sanctuary.
La Scuola Superiore Meridionale a Pompei. Indagini lungo il Portico Orientale del Foro Triangolare: campagna di scavo 2022.
Authors: Massimo Osanna  , Daniele Alessi  , Rosanna De Candia
Published: September 2024

Scelto in età arcaica come sede di uno dei principali luoghi di culto della città, il cosiddetto Foro Triangolare è stato al centro della vita pubblica e religiosa dell’antica Pompei fino all’eruzione del 79 d.C. Sulla scia delle più recenti indagini, il Parco Archeologico di Pompei ha promosso, in collaborazione con la Scuola Superiore Meridionale, una nuova campagna di scavo lungo il braccio orientale del portico che cinge l’area sacra, del quale è stato documentato un tratto della fondazione muraria che ha tagliato i piani di frequentazione più antichi e raggiunto i depositi eruttivi protostorici sottostanti: sono state quindi recuperate informazioni significative circa la conformazione geomorfologica del sito e le attività antropiche che, almeno in questo settore del santuario, hanno preceduto la costruzione del monumento colonnato.
Founded in the archaic period, the so-called Triangular Forum is one of the longest-lived sanctuaries at Pompeii and offers the possibility to investigate all the principal historical phases of the ancient city. Following the last important excavation campaigns, the Archaeological Park of Pompeii, in collaboration with the Scuola Superiore Meridionale, has promoted new research on the portico that encircles the sacred precinct: important information has been acquired about the geomorphological structure of the site and the anthropic activities carried out in this area before the construction of the colonnade.
La campagna di scavo 2023 nel Peristilio Superiore di Villa San Marco a Stabiae
Authors: Maria Luisa Catoni  , Carlo Rescigno  , Paolo Baronio  , Mariamafalda Crisci  , Silvio La Paglia  , Riccardo Olivito
Published: September 2024

Tra la primavera e l’autunno del 2023 è stata effettuata la seconda campagna di scavo nel Peristilio Superiore (o Loggia del Planisfero) di Villa San Marco a Stabiae, condotta dalla Scuola IMT Alti Studi Lucca, dalla Scuola Superiore Meridionale e dall’Università degli Studi della Campania Luigi Vanvitelli, in convenzione e con il supporto scientifico e tecnico del Parco Archeologico di Pompei. Le indagini si sono concentrate presso l’angolo sudoccidentale del colonnato, in parte già esplorato nei livelli superficiali durante la missione del 2020, dove è stato possibile raggiungere il piano pavimentale in terra battuta e mettere in luce per tutta la loro altezza alcuni tratti delle pareti, interamente affrescate da un elaborato ciclo pittorico in Quarto Stile. L’analisi dei dati stratigrafici e delle dinamiche di crollo ha confermato che i diversi settori del portico resistettero in modo differenziato alla pioggia di lapilli e alla successione dei flussi piroclastici. Inoltre, il recupero e la ricomposizione di ampi crolli di pitture parietali e di soffitto, nonché di elementi architettonici in stucco pertinenti alla decorazione delle colonne e degli architravi, hanno fornito nuovi dati per ricostruire l’immagine di questo lussuoso settore della villa.
Between Spring and Autumn 2023, the second campaign of excavation in the Peristilio Superiore (or Loggia del Planisfero) of Villa San Marco at Stabiae was carried out by the IMT School for Advanced Studies Lucca, Scuola Superiore Meridionale and Università degli Studi della Campania “Luigi Vanvitelli”, under the aegis of the Parco Archeologico di Pompei. The investigation focused on the southwestern corner of the colonnade, partially already explored in the superficial layers during the 2020 mission, where it was possible to reach the level of the earthen floor and bring to light for the entire height some segments of the walls, completely frescoed by an elaborate pictorial cycle in Fourth Style. The analysis of the stratigraphic data and the dynamics of fall has confirmed that the various portions of the portico withstood in differentiated way the lapilli rain and the sequence of the pyroclastic flows. Furthermore, the recovery and the reconstruction of extended portions of collapsed wall and ceiling paintings, as well as of architectural elements in stucco pertaining to the decoration of the columns and architraves, have provided new data in order to recreate the image of such a luxurious sector of the villa.
Cuma, Acropoli: lo scavo della terrazza triangolare (campagne 2019-2023)
Authors: Andrea Averna
Published: September 2024

Le ricerche dell’Università della Campania e della Scuola Superiore Meridionale sul pianoro posto alle pendici sud-occidentali della terrazza superiore dell’acropoli di Cuma presero avvio nel 2018. Tra la primavera e l’estate di quell’anno fu condotta una campagna di indagini geognostiche (prospezioni georadar e geomagnetiche), che evidenziarono forti anomalie imputabili a strutture lineari con orientamento sud-ovest/nord-est, concentrate soprattutto a nord, nel punto in cui i fianchi della collina si addolciscono e lasciano il passo al plateau di forma triangolare.Si tratta di un’area che si prefigurava di estremo interesse, mai indagata in passato, e che per la sua posizione, subito a ovest della via sacra e a sud dell’abitato terrazzato di epoca medievale, doveva aver svolto un ruolo di primo piano nell’urbanistica e nella topografia sacra dell’acropoli, in tutte le fasi della sua storia.
ABU RAYHON BERUNIY QARASHLARINING FALSAFIY TAFAKKUR RIVOJLANISHIDAGI AHAMIYATI
Authors: Ibragimov Begzod
Published: September 2024

This article is devoted to the important role of the ontological and epistemological views and teachings of Abu Rayhan Beruni, the great thinker of the Renaissance in Central Asia, in the philosophical understanding of the rings in the society of that time.
YOSHLARDA SOG‘LOM TAFAKKUR MADANIYATINI SHAKLLANTIRISHDA MAHALLA VA TA’LIM TIZIMINING ROLI
Authors: Atakulov Mavlonbek
Published: September 2024

This article emphasizes the importance of family-neighborhood-educational institutions cooperation in bringing up a healthy young generation and large-scale reforms implemented in our country. The main goal of the great changes and reforms being carried out in the process of education of young people at the level of our country is to train well-educated, morally mature and competitive personnel.
АБУ ЖАЪФАР ТЕРМИЗИЙНИНГ ҲАДИС РИВОЯТИДА ТУТГАН ЎРНИ
Authors: Uljaev Umarali
Published: September 2024

In the article, the importance of the hadiths narrated by Abu Ja'far Termizi and their place in the science of hadith are scientifically analyzed. The importance of scientific heritage in Islamic civilization is also revealed.
Design of Virtual Reality System for 3D Visualization and Interaction
Authors:   Souphanouvong University, Kounlaxay Kalaphath
Published: September 2024

Nowadays, a virtual environment or metaverse environment is becoming more popular and can be used for various purposes. There are many computer games and more applications for them such as for training, learning and planning. Currently the presentations of 3-Dimensional (3D) models using mixed reality (MR) technology can be used to avoid misinterpretations of oral and 2-Dimensional (2D) model presentations. As an independent concept and MR applications, MR combines the best of virtual reality (VR) and augmented reality (AR). Therefore, this research aimed to present the descriptions of MR systems, which include its devices, applications, literature reviews and create 3D models that were then implemented in Unity 3D using VR applications for 3D architectural visualization. In addition, the assessment results of the VR application showed that the mean score of 2.85 and 3.45 (“neutral”) indicated that the VR application was a new one for the students and they had never used it before, but they certify that learning with VR is not as difficult as with other simulations. The mean scores of 4.55, 4.70, and 4.75 (“strongly agree”) indicated that the use of the VR application’s 3D objects in the scene was beautiful, clear, and realistic. Besides, the student also enjoyed the immersive experience and the learning was very interesting and they felt that they were in the real world.
Language Culture of Loan Words in Lao Language Dictionary
Authors:   Souphanouvong University, DUANGCHAN Boy
Published: September 2024

The research simed to investigates the loan words from the Pali language that appears in the Lao language dictionary and to categorize its language culture that appears in the language dictionary. The study was conducted through an analysis of the loan words from the Pali language that appears in the Lao language dictionary to classify the words based on the cultural characteristics of the language, according to the Voegelins’ language culture division. The results revealed that there are 3,695 loan words from the Pali language. They are divided into four main categories: 1) nature, 2) human and human behavior, 3) wisdom, emotions, feelings and values, and 4) individual relationship. The loan words based on Voegelins’ language culture division, can be concluded as follows: the category of wisdom, emotions, feelings, and values takes the highest proportion with the number of 1,355 words, accounting for 36.67 per cent. There are 926 words about the religiousness, legends, beliefs, rituals, ceremonies, instruments, and the places for ceremony, accounting for 25.06 per cent. There are 617 words in the human beings and human behavior category, accounting for 16.69 per cent. However, there are only 27 words about dressing, accessories, hats, hairstyles, shoes and care accounting for 0.73 per cent.
A Study on Lao Phuan Vernacular House in Ngan Area, Khoun District, Xieng Khuang Province
Authors:   Souphanouvong University, Daravong Sinthavone
Published: September 2024

The study on vernacular houses of the Lao Phuan ethnic group aims to determine the area that still retains most of its original form, as defined by the fieldwork of Ngan area in Khoun District, Xieng Khouang Province as a case study. The selected area is the only one that still has a large number of traditional houses left behind. Through the study of relevant documents, physical surveys with maps and observations, random measurements of house components, and in-depth interviews with village chiefs, the elderly, and residents in the village: These Lao Phuan vernacular houses are designed and built to meet the needs of their occupations and to suit the nature or environment of the area in which they reside. Including their traditions, culture, and way of living. This can be seen from using materials that are easy to find, durable in use, and abundant locally, such as using Longleng wood as a roofing material. In addition, to being a natural sense, it is also an extra sun and rain-resistant material, making it usable for decades. At the same time, the style of the house has long eaves with small windows, which is due to the fact that the area is located in an area with high rainfall. In addition, the stilt house form will be used as a storage area for daily production equipment, firewood, fishing tools, and weaving equipment, as well as for survival and safety conditions. The use of space inside the house, in addition to allocating the area to serve a basic living, also allocated a large hall area to accommodate guests or relatives who visit regularly. Especially when there are traditional events held in the village or gift ceremonies inside the house. Another important point is that the area has to adapt to the dry season (winter). Therefore, two fireplaces have been set up; the first is in the cooking area. The second point is in the living area to use the fireplace to keep warm, the process of building a house still follows the strict traditions and beliefs that have been practiced for a long time.
Menelaah Dinamika Leverage, Tata Kelola Perusahaan, dan Atribut Perusahaan dalam Membentuk Penghindaran Pajak di Kalangan Perusahaan yang Terdaftar di LQ45
Authors: Ayu Lestari Mey , Anjarningsih Dwi
Published: September 2024

Tujuan: Penelitian ini bertujuan untuk mengeksplorasi hubungan yang rumit antara mekanisme tata kelola perusahaan, leverage keuangan, dan karakteristik perusahaan dalam konteks penghindaran pajak di antara perusahaan-perusahaan publik.Metode: Dengan menggunakan pendekatan kuantitatif, penelitian ini menganalisis kumpulan data perusahaan yang komprehensif dengan menggunakan teknik statistik canggih untuk menilai dampak variabel independen terhadap penghindaran pajak.Hasil: Temuan ini mengungkapkan hubungan yang signifikan antara tata kelola perusahaan, leverage keuangan, dan perilaku penghindaran pajak, yang menyoroti kompleksitas hubungan ini dalam lingkungan perusahaan.Kebaruan: Penelitian ini berkontribusi pada literatur yang ada dengan mengintegrasikan kerangka kerja teoritis tentang tata kelola dan keuangan, menawarkan wawasan baru ke dalam mekanisme yang mempengaruhi strategi pajak di pasar negara berkembang.Implikasi Praktis: Hasil penelitian ini menggarisbawahi pentingnya meningkatkan praktik-praktik tata kelola perusahaan untuk mengurangi penghindaran pajak, memberikan rekomendasi yang berharga bagi para pembuat kebijakan dan pemimpin perusahaan.
Fire safety: hydraulic systems used in underground work
Authors:   Health and Safety Exeutive, Jagger Stuart
Published: September 2024

The aim of this work was to obtain a fuller understanding of current day risks of fire underground due to hydraulic power transmission systems and the fluid used in them.
Area Classification for Oil Mists (MISTS2): Summary Report
Authors: Bettis Richard
Published: September 2024

This report describes research under the ‘MISTS2’ project to produce experimental evidence about the ignition of mist clouds. The project focused on experiments where the results can be directly used to give the greatest improvement in understanding of mist explosion safety.
Management Strategies for Nutrient Stress in Honeybee Colonies Due to Climate Change
Authors: Sonmez Oskay Gizem , Oskay Devrim
Published: September 2024

Honey bees, scientifically known as Apis mellifera L., play a crucial role as pollinators, being vital for both biodiversity and agricultural output. Honey bee numbers are declining due to a variety of pressures, with climate change being a significant factor despite their ability to adapt. Honey bees, being ectothermic species, are quite vulnerable to changes in their environment, such as increasing temperatures, changing patterns of precipitation, and severe weather events. These changes disrupt the process of searching for food, diminish the availability of flowers as a source of sustenance, and heighten susceptibility to diseases and pests, ultimately resulting in nutritional strain. This study examines the immediate and indirect consequences of climate change on honey bee colonies, emphasizing the influence of severe temperatures and changes in floral resources on their well-being and capacity to survive. Additionally, it scrutinizes current colony management strategies aimed at mitigating nutritional stress. We examine the possibility of alternative diets that include proteins, lipids, vitamins, phytochemicals, and probiotics to support honey bee health in the face of environmental stress. Furthermore, we are conducting an investigation into the use of food waste items as nutritious supplements. It is crucial to prioritize ongoing research and development of efficient alternative diets in order to ensure the long-term survival of honey bee populations in light of climate change. By implementing these tactics, beekeepers may improve colony resilience and boost biodiversity and agricultural production.
Bacterial Diseases of Honeybees and Biochemical Tests That Play a Role in the Diagnosis of Diseases
Authors: Tahiroglu Veysel
Published: September 2024

Honey bees are considered a superorganism consisting of thousands of individuals and include queen, worker and drone bees. Many bacterial diseases, especially brood rot, are seen in honey bees. Since honey bees contribute to the easy spread of infections due to their proximity within the hive and their foraging habits, the diagnosis and control of these diseases has a very critical function for the sustainability of the beekeeping sector. In this respect, it has led scientists to develop new and reliable diagnostic methods for the accurate and rapid diagnosis of bee diseases. Therefore, the importance of biochemical parameters, molecular tests and microbiological tests is increasing day by day to quickly and accurately diagnose bacterial diseases. In this section, information will be given about important bacterial diseases of honey bees and their diagnostic methods.
Reporte de huevo sobredimensionado del cocodrilo americano Crocodylus acutus en el museo del Cocodrilario Ejido La Manzanilla, Jalisco
Authors: Cupul-Magaña Fabio G. , Martínez-Rodríguez José Eliazar , Tello-Sahagún Luis Ángel , Escobedo Galván Armando Hiram
Published: September 2024

The observation of an oversized egg of the American crocodile (Crocodylus acutus) in exhibition at Ejido La Manzanilla crocodile farm museum, located in La Manzanilla del Mar village on the southern coast of Jalisco, Mexico, was recorded. The oversized egg is from a wild nest laid on 12 April 2013, on the sandy bar at the mouth of the La Manzanilla estuary adjacent to the museum. The egg weighed 500 g, with a length of 22.50 cm (measured linearly), and width ranged from 5.70 cm to 6.0 cm. The etiology of the oversized egg is unknown; however, it may be due to a low level of calcium in the diet ration of the breeding female.
2018 Italian political elections: Lega and the construction of a threat narrative
Authors: Del Rizzo Francesca
Published: September 2024

Lega is an Italian party that had a major role in recent political elections in Italy. It came out as the third party in the country and the first in the North. By means of a Personal Construct Psychology (Kelly, 1955) perspective, in this paper I will ipothesize that Salvini’s Lega conquered the vote of so many Italians thanks to rhetoric of threat. This hypothesis is tested by means of the analysis of the constructs emerging from the election campaign main slogans. Eventually some reflections are made on the constructs used by many of the persons living in the North of Italy to read the current situation of the country.
What does taking care mean? A story about a caregivers group and an observer
Authors: Toffano Roberta
Published: September 2024

In this article I propose a constructivist reading of my experience, that I lived as an observer, within a psychological support group aimed at people who were facing the consequences of a neurological event of one of their relatives. Very often, in these situations, people experience a sudden upheaval in their lives, with important emotional consequences. Using the narrative theme, I chose to tell the story of these people and this group.
Enhancing Concrete Properties with Banana Stem Juice Additive: A Study on Workability and Compressive Strength
Authors: Dadzie Donald Kwabena , Mustapha Zakari , Akomah Benjamin Boahene
Published: September 2024

Additives are integral components of modern concrete mixing materials. This study aimed to evaluate the workability and compressive strength of concrete incorporating banana stem juice as a natural additive (BSJA). A laboratory experiment was conducted to assess the impact of BSJA on concrete properties. Concrete mixtures with a ratio of 1:2:4 were prepared both with and without BSJA. A total of 36 cube specimens were created with varying percentages of banana stem juice, and their compressive strengths were measured. The results indicated that the inclusion of banana stem juice affected the concrete properties. On the 21st day, the compressive strength of the concrete without BSJA was 27.67 N/mm², compared to 29.67 N/mm² for 5% BSJA, 16.33 N/mm² for 10% BSJA, and 8.00 N/mm² for 15% BSJA. The slump values recorded were 15 mm for 0% BSJA, 20 mm for 5% BSJA, 45 mm for 10% BSJA, and 65 mm for 15% BSJA. The average compressive strengths of concrete specimens with 5% BSJA at 14 days (23.3 N/mm²) and 21 days (29.2 N/mm²) were higher than those of specimens without BSJA. Over the 14 and 21-day periods, specimens with BSJA consistently showed higher compressive strengths compared to those without. These results suggest that 5% BSJA enhances the compressive strength properties of concrete.
Prevalência de internações e óbitos por infarto agudo do miocárdio no Brasil
Authors: Fonseca Fernando Guimarães , Pessoa Iury Marcos da Silva , Veloso Fernanda Moreira Fagundes , Ferreira Ana Célia Guedes Roque
Published: September 2024

Objetivo: Analisar a prevalência de internações e óbitos por infarto agudo do miocárdio no Brasil entre janeiro de 2015 a junho de 2024. Metodologia: Trata-se de um estudo retrospectivo, descritivo, quantitativo, de base documental. Os dados foram obtidos do Sistema de Informações Hospitalares do SUS (SIH/SUS), pelo Departamento de informática do SUS (DATASUS). Resultados: No período avaliado, foram registradas 1.255.839 internações por infarto agudo do miocárdio no Brasil. Em 2023 observou-se o maior número de internações (171.950), sendo notado maior taxa de mortalidade (11,76%) em 2015. Houve predomínio de internações no sexo masculino (63,57%), na faixa etária entre 60 a 69 anos (30,94%) e na cor/raça branca (40,89%). Conclusão: O infarto agudo do miocárdio tem alta prevalência nas regiões do Brasil e provoca impactos relevantes na qualidade de vida dos pacientes.
A Comparative Analysis of State Pollinator Protection Laws
Authors: Baer Sophia
Published: September 2024

Various states in the U.S. have passed laws to regulate pesticide use for agriculture and prohibit excessive harm to pollinators. However, current online public information on pollinator protection laws in America is largely lacking. This study establishes an inventory of the state legislation that has banned neonicotinoid pesticides and protected pollinators. The results of this review indicate that only sixteen states have enacted neonicotinoid bans, none of which are complete bans. Sixteen states had no portion of their agricultural website dedicated to pollinator conservation and did not address bees or pollinators at all except when referencing pest control. These same states had no legislation or ban on neonicotinoids. In sixteen states neonicotinoids are labeled as restricted use, however, finding information on neonicotinoid regulation and defining restricted use was difficult. Overall, there is a lack of clarity and consistency across state legislation. There are inconsistent policies across the U.S., but the states that have more progressive policies also are more conscious of the environment and conservation. The implementation of federal legislation would be most effective at unifying the states and creating widespread pollinator conservation.
New Frontiers in the Control of Influenza
Authors:   Mednet, von Riedemann Sarah
Published: September 2024

In normal times, the Canadian Immunization Conference (CIC) takes place every two years, bringing together public health officials, community advocates, and researchers and clinicians with an interest in vaccines and vaccine- preventable diseases. Due to the COVID-19 pandemic, the conference had not taken place in person since 2018 – in part due to restrictions on travel and gatherings, but also because many attendees were heavily involved in managing the most wide-ranging public health crisis of our time, including the largest mass vaccination campaign in human history. CIC 2023 was a long-awaited opportunity to appreciate the efforts and successes of the response to COVID-19, and to look ahead to how advances in vaccine technologies and improvements in public health processes might help us close a significant gap in immunizations against other vaccine-preventable diseases that occurred over those years. This report will focus on presentations and perspectives relevant to routine immunization programs against seasonal influenza in Canada.
New Frontiers in Alzheimer's Support
Authors: Haller Andrew ,   Launchit Solutions
Published: September 2024

Alzheimer’s disease (AD) and related dementia diagnoses are very prevalent in Canada. Approximately 733,040 people in Canada are currently living with dementia, and that number is estimated to grow to nearly 1 million Canadians by 2030. (1) AD is the most common type of dementia, an overall term for conditions that cause problems with memory, thinking and behaviour. In the early stage, dementia symptoms may be minimal, but as the disease causes more damage to the brain, symptoms worsen. The rate at which the disease progresses is different for everyone, but on average, people with AD live for roughly eight years after symptoms begin.
A new option for the inoperable: Insights into management of NF1-associated plexiform neurofibromas
Authors:   Mednet, von Riedemann Sarah
Published: September 2024

he NF Conference is the flagship annual meeting of the US-based Children’s Tumor Foundation. This June, more than 700 participants from around the world gathered at the Fairmont Scottsdale Princess in Scottsdale, Arizona, to discuss the latest research, opinions, and clinical guidance about the rare hereditary cancer disorders neurofibromatosis and schwannomatosis. Neurofibromatosis type 1 (NF1) is the most common form of neurofibromatosis, caused by a mutation in the NF1 gene that codes for the tumor suppressor protein neurofibromin, resulting in dysregulation of the RAS-MAPK signalling pathway. The clinical presentation of NF1is highly variable but the most common manifestations include changes in skin pigmentation (most typically cafe´- au-lait macules and unusual axial and/or inguinal freckling), learning and developmental delays, and the development of multiple neurofibromas on the skin (cutaneous neurofibromas, cNF) and/or peripheral nerve sheaths (plexiform neurofibromas, PN). This report will focus on insights into the importance of PN in patients with NF1, and on advances in the management of NF1-associated PN.
Hematology in a time of COVID: Update on Paroxysmal Nocturnal Hemoglobinuria (PNH)
Authors:   Mednet, Leask Helen
Published: September 2024

This year’s European Hematology Association meeting (EHA2021) covered the new medical realities of hematology during the COVID-19 pandemic. Expert panels discussed the impact of SARS-CoV-2 on clinical decision-making in prothrombotic hematological diseases such as PNH. Despite the rarity of the disease, data and commentary on PNH were prominent in the five-day meeting due to rapid advances in the field. In addition to discussing COVID-19 vaccination in patients with PNH, presenters updated delegates on new therapies aiming to join gold-standard eculizumab in clinical practice. Nearly 20 PNH abstracts and e-posters and 12 scientific presentations featured studies on pegcetacoplan, ravulizumab and first-in-class oral therapy iptacopan, among others.
Analisis Perangkat Pembelajaran Daring Berdasarkan Survei Siswa Akibat Pandemi Covid-19
Authors: Yonalia Siti , Gunawan Putu Harry
Published: September 2024

The Covid-19 pandemic situation in 2021 resulted in various changes in various sectors, including education. Various methods were used to maintain learning activities by reducing physical contact to prevent the spread of the virus. The shift from face-to-face learning to online quickly led to new problems that reduced the effectiveness of student learning. These issues are caused by suboptimal internet network quality, difficulty in adapting to online learning methods, and differences in understanding material through video conferencing applications. This research aims to provide a comprehensive explanation of the effectiveness of online learning in the short and long term using non-parametric statistics and categorical data analysis through Chi-Square tests. The research sample consists of 150 students from universities in Jakarta and Bandung
THE INFLUENCE OF DIGITAL LIBRARY SERVICE QUALITY ON STUDENT SATISFACTION
Authors: Siregar Nurul Zahara , Syam Abdi Mubarak
Published: September 2024

This research was conducted with the aim of knowing the effect of digital service quality on student satisfaction at the State Islamic University of North Sumatra. This research is a quantitative research. Data collection techniques used in the form of a questionnaire / questionnaire. The selected sample is 100 respondents based on the slovin formula. The method used is a survey research method using a quantitative data analysis approach. The data analysis technique used is data quality test, classic assumption test, and hypothesis test. The results showed that the results of the T test obtained t-count > t-table or (2.327 > 1.660) and the value of Sig. (0.000 <0.05). This shows that there is a positive and significant influence on the quality of digital library services on the level of student satisfaction and the R Square value is 0.52, which means 52% that the magnitude of the influence of digital library service quality on student satisfaction at the State Islamic University of North Sumatra is 52%.
ANALYSIS OF THE INFLUENCE OF DIGITALIZATION ON THE DEVELOPMENT OF HALAL UMKM
Authors: R Hediansyah , S Suryansyah , S Fauziah , Risnawati Risnawati
Published: September 2024

Digitalization has benefits for business actors, one of which is MSME players. Digitalization has advantages such as making it easier to attract consumers through digital or online marketing, reducing costs, and expanding marketing networks. Digital marketing basically has quite a positive influence, but the use of digital marketing is still very low due to the readiness factor, which is still an obstacle for MSME players in Indonesia. Therefore, this research was made with the aim of analyzing the effect of digital marketing on halal MSMEs around the Gunadarma University campus using the digitalization marketing variable approach (X1) and literacy variable (X2) on the development of halal MSMEs (Y). The method in this study is descriptive-qualitative and uses primary data obtained through structured interviews with halal MSMEs, especially those around the Gunadarma University campus in Kelapa Dua, Depok City. The sample used in this study was 10 respondents from halal MSME actors around the Gunadarma Depok campus.
Binek Otomobil İthalatının Yapısı: Bazı Tespitler ve Öneriler
Authors: Eken Ahmet Adnan , Yazıcı Didem
Published: September 2024

Bu çalışmada tüketim malları ithalatının en önemli kalemini oluşturan binek otomobil ithalatının yapısı incelenmiş, sektör ithalatının fiyat ve gelir esneklikleri tahmin edilerek ithal ikamesini artırıp, ithalatı azaltacak öneriler sunulmuştur. Bulgular binek otomobil ithal talebinin fiyat ve gelirdeki gelişmelere duyarlı olduğunu göstermektedir. Buna göre sektörde rekabetçi yerli üretim alternatifinin olması kura bağlı fiyat artışlarında tüketici tercihlerinin yerli ürüne yönelmesine yol açabilmektedir. Bununla birlikte ilave makro ihtiyati önlemlerin bu sürece katkı sağlayabileceği değerlendirilmektedir.
OECD Üyesi Ülkelerin Çevre Koruma Harcamalarının Etkinliğinin Belirleyicileri: İki Aşamalı Veri Zarflama Analizi Uygulaması
Authors: Koç Arslan Senem , Gürler Hazman Gülsüm
Published: September 2024

Günümüzde yaşanan ve giderek ciddileşen çevresel sorunlar devletleri ve uluslararası örgütleri iklim, çevre ve bunların yönetimi ile ilgili çalışmalar yapmaya, tedbirler almaya ve alternatif politikalar üretmeye zorlamaktadır. Bu kapsamda ülkelerin çevre politikalarına bir perspektif sunmak ve politika geliştirmede yol gösterici olması adına çevre koruma harcamalarını incelemek önem arz etmektedir. Bu çalışmada seçili OECD ülkelerinin çevre koruma harcamalarının etkinliğini görmek ve bu etkinliği belirleyen faktörleri tespit etmek üzere iki aşamalı veri zarflama analizi uygulanmış. 30 OECD ülkesinin 2008-2020 yılları arası çevre koruma harcamalarının etkinliğini belirlemek için veri zarflama analizi-süper etkinlik modeli kullanılmıştır. Yapılan ekinlik analizinde kamu çevre koruma harcamaları girdi olarak kullanılırken ülkelerin yenilenebilir enerji üretimi, ormanlık alan miktarı, CO2 emisyonu, P.M. 2.5 partikül madde maruziyeti ve kişi başı GSYH miktarı çıktı olarak kullanılmıştır. Kullanılan çıktılarda karbondioksit emisyonu ve P.M. 2.5 partikül madde maruziyeti istenmeyen çıktı (undesirable output) olarak yer almıştır. İkinci aşamada ise bu etkinlik skorlarının belirleyicilerini ölçmek üzere klasik panel veri analizi uygulanmıştır. Analiz sonucunda ekonomik büyüme arttıkça çevre koruma harcamalarının etkinliği artmakta; nüfus yoğunluğu dikkate alındığında ise, nüfus yoğunluğu arttıkça çevre koruma harcamalarının etkinliği azalmaktadır.
Establishing comprehensive quaternary structural proteomes from genome sequence
Authors: Catoiu Edward Alexander , Mih Nathan , Lu Maxwell , Palsson Bernhard
Published: September 2024

A critical body of knowledge has developed through advances in protein microscopy, protein-fold modeling, structural biology software, availability of sequenced bacterial genomes, large-scale mutation databases, and genome-scale models. Based on these recent advances, we develop a computational framework that; i) identifies the oligomeric structural proteome encoded by an organism’s genome from available structural resources; ii) maps multi-strain alleleomic variation, resulting in the structural proteome for a species; and iii) calculates the 3D orientation of proteins across subcellular compartments with residue-level precision. Using the platform, we; iv) compute the quaternary
E. coli
K-12 MG1655 structural proteome; v) use a dataset of 12,000 mutations to build Random Forest classifiers that can predict the severity of mutations; and, in combination with a genome-scale model that computes proteome allocation, vi) obtain the spatial allocation of the
E. coli
proteome. Thus, in conjunction with relevant datasets and increasingly accurate computational models, we can now annotate quaternary structural proteomes, at genome-scale, to obtain a molecular-level understanding of whole-cell functions.
Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis
Authors: Sharma Priya , Sharma Raman Deep , Das Mrinmoy , Sarkar Binayak , Singh Lakshyaveer , Jain Neharika , Chaturvedi Shivam , Mehra Lalita , Rathee Aditya , Sharma Shilpa , Foo Shihui , Lee Andrea , kumar N Pavan , Das Prasenjit , Viswanathan Vijay , Kornfeld Hardy , Howland Shanshan W , Babu Subash , Nandicoori Vinay , Singhal Amit , Kumar Dhiraj
Published: September 2024

The protective correlates of
Mycobacterium tuberculosis
(
Mtb
) infection-elicited host immune responses are incompletely understood. Here, we report pro-pathogenic crosstalk involving Ly6G
+
granulocytes (Ly6G
+
Gra), IL-17 and COX2. We show that in the lungs of
Mtb
-infected wildtype mice, either BCG-vaccinated or not, most intracellular bacilli are Ly6G
+
Gra-resident four weeks post-infection onwards. In the genetically susceptible

IFNγ
−/−

mice, excessive Ly6G
+
Gra infiltration correlates with severe bacteraemia. Neutralizing IL-17 (anti-IL17mAb) and COX2 inhibition by celecoxib reverse Ly6G
+
Gra infiltration, associated pathology and death in

IFNγ
−/−

mice. Surprisingly, Ly6G
+
Gra also serves as the major source of IL-17 in the lungs of
Mtb
-infected WT or

IFNγ
−/−

mice. The IL-17-COX2-Ly6G
+
Gra interplay also operates in WT mice. Inhibiting RORγt, the key transcription factor for IL-17 production or COX2, reduces the bacterial burden in Ly6G
+
Gra, leading to reduced bacterial burden and pathology in the lungs of WT mice. In the
Mtb
-infected WT mice, COX2 inhibition abrogates IL-17 levels in the lung homogenates and significantly enhances BCG’s protective efficacy, mainly by targeting the Ly6G
+
Gra-resident
Mtb
pool. Furthermore, in pulmonary TB patients, high neutrophil count and IL-17 correlated with adverse treatment outcomes. Together, our results suggest that IL-17 and PGE2 are the negative correlates of protection, and we propose targeting the pro-pathogenic IL-17-COX2-Ly6G
+
Gra axis for TB prevention and therapy.
Asynchronous mouse embryo polarization leads to heterogeneity in cell fate specification
Authors: Lamba Adiyant , Zhu Meng , Meglicki Maciej , Czukiewska Sylwia , Balasubramaniam Lakshmi , Hadas Ron , Weishaupt Nina , Patel Ekta M , Kavanagh Yu Hua , Wang Ran , Jing Naihe , Zernicka-Goetz Magdalena
Published: September 2024

The first lineage allocation in mouse and human embryos separates the inner cell mass (ICM) from the outer trophectoderm (TE). This symmetry breaking event is executed through polarization of cells at the 8-cell stage and subsequent asymmetric divisions, generating polar (TE) and apolar (ICM) cells. Here, we show that embryo polarization is unexpectedly asynchronous. Cells polarizing at the early and late 8-cell stage have distinct molecular and morphological properties that direct their following lineage specification, with early polarizing cells being biased towards producing the TE lineage. More recent studies have also implicated heterogeneities between cells prior to the 8-cell stage in the first lineage allocation: cells exhibiting reduced methyltransferase CARM1 activity at the 4-cell stage are predisposed towards the TE fate. Here, we demonstrate that reduced CARM1 activity and upregulation of its substrate BAF155 promote early polarization and TE specification. These findings provide a link between asymmetries at the 4-cell stage and polarization at the 8-cell stage, mechanisms of the first lineage allocation that had been considered separate.
Visualization of endogenous G proteins on endosomes and other organelles
Authors: Jang Wonjo , Senarath Kanishka , Feinberg Gavin , Lu Sumin , Lambert Nevin A
Published: September 2024

Classical G protein-coupled receptor (GPCR) signaling takes place in response to extracellular stimuli and involves receptors and heterotrimeric G proteins located at the plasma membrane. It has recently been established that GPCR signaling can also take place from intracellular membrane compartments, including endosomes that contain internalized receptors and ligands. While the mechanisms of GPCR endocytosis are well understood, it is not clear how well internalized receptors are supplied with G proteins. To address this gap we use gene editing, confocal microscopy, and bioluminescence resonance energy transfer to study the distribution and trafficking of endogenous G proteins. We show here that constitutive endocytosis is sufficient to supply newly internalized endocytic vesicles with 20-30% of the G protein density found at the plasma membrane. We find that G proteins are present on early, late, and recycling endosomes, are abundant on lysosomes, but are virtually undetectable on the endoplasmic reticulum, mitochondria, and the medial Golgi apparatus. Receptor activation does not change heterotrimer abundance on endosomes. Our findings provide a subcellular map of endogenous G protein distribution, suggest that G proteins may be partially excluded from nascent endocytic vesicles, and are likely to have implications for GPCR signaling from endosomes and other intracellular compartments.
Cell class-specific long-range axonal projections of neurons in mouse whisker-related somatosensory cortices
Authors: Liu Yanqi , Bech Pol , Tamura Keita , Délez Lucas T , Crochet Sylvain , Petersen Carl CH
Published: September 2024

The extensive long-range axonal projections of diverse classes of neocortical excitatory neurons are thought to contribute importantly to the highly integrative brain-wide interactions underlying the processing of sensory, cognitive and motor signals. Here, we investigated the long-range axonal output of various classes of genetically-defined projection neurons with cell bodies located in the whisker-related somatosensory cortices of the mouse through brain-wide light-sheet imaging of fluorescently-labeled axons segmented by specifically-trained convolutional networks quantified within the Allen Mouse Brain Atlas Common Coordinate Framework. We injected Cre-dependent virus to express GFP or tdTomato in the posterior primary somatosensory barrel cortex and the posterior supplemental somatosensory cortex, which contain the representations of the large posterior mystacial whiskers. We investigated the six following transgenic mouse lines which preferentially express Cre in different glutamatergic neocortical cell classes: Rasgrf2-dCre for layer 2/3 intratelencephalic projection neurons, Scnn1a-Cre for layer 4 intratelencephalic projection neurons, Tlx3-Cre for layer 5 intratelencephalic projection neurons, Sim1-Cre for layer 5 pyramidal tract projection neurons, Rbp4-Cre for layer 5 projection neurons and Ntsr1-Cre for layer 6 corticothalamic neurons. We found long-range axonal projections in many diverse downstream brain areas with largely similar output from primary and secondary cortices, but with genetically-defined cell classes showing distinct innervation patterns, with Rbp4-Cre mice showing the broadest innervation targets, subsets of which were innervated in the other mouse lines. To test whether the revealed axonal projections might underpin functional circuits, we compared the spatial organization of the axonal innervation with functional connectivity maps obtained from optogenetic stimulation of sensory cortex and wide-field imaging of the activity propagation to frontal cortices. Both methods indicated that neurons located more laterally in somatosensory cortex topographically signaled to more anteriorly located regions in motor cortex. The current methodology therefore appears to quantify brain-wide axonal innervation patterns supporting brain-wide signaling, and, together with further technological advances, this will help provide increasingly detailed connectivity information of the mouse brain, essential for understanding the complex neuronal circuitry underlying even simple goal-directed behaviors.