bluuebunny/crossref_metadata_2025 huggingface dataset:
Viabilidade agronômica de hortaliças fertilizadas com flor-de-seda (Calotropis procera (Ait.) R.Br.)
Authors:   , Silva Maiele Leandro da
Published: November 2024

Três experimentos (um com cenoura, um com rúcula e outro com coentro) foram conduzidos na Fazenda Experimental Rafael Fernandes, no período de outubro de 2010 a janeiro de 2012, com o objetivo de determinar a quantidade de flor-de-seda incorporada ao solo e o(s) tipo(s) de parcelamento dessa quantidade que devem ser usados no desempenho agroeconômico da cenoura, bem como, de quantificar a(s) quantidade(s) de flor-de-seda e seu(s) tempo(s) de incorporação a serem utilizados na performance agroeconômica da rúcula e do coentro. O delineamento experimental usado foi de blocos completos casualizados com três repetições, em esquema fatorial 4 x 3 para a cenoura e para a rúcula. Os tratamentos do experimento da cenoura consistiram de quatro quantidades de flor-de-seda (6; 19; 32 e 45 t ha-1 em base seca), parceladas em três proporções (30% quinze dias antes da semeadura (DAS) + 70% trinta dias depois da semeadura (DDS), 40% quinze DAS + 60% trinta DDS e 50% quinze DAS + 50% trinta DDS). Para o experimento da rúcula, os tratamentos foram constituídos pela combinação de quatro quantidades de flor-de-seda (6; 19; 32 e 45 t ha-1 em base seca) com três tempos de incorporação (10; 20 e 30 DAS). Para o experimento do coentro, o esquema fatorial foi de 4 x 4. Os tratamentos consistiram da combinação de quatro quantidades de flor-de-seda (7,5; 15; 22,5 e 30 t ha-1 em base seca) com quatro tempos de incorporação (0, 10, 20, e 30 DAS). As cultivares de cenoura, rúcula e coentro plantadas foram respectivamente: Brasília , Cultivada e Verdão . As características avaliadas na cenoura foram: altura de plantas, número de hastes por planta, massa seca da parte aérea, produtividade comercial, total e classificada de raízes. Para as culturas de rúcula e coentro foram: altura de plantas, número de folhas ou hastes por planta, rendimento de massa verde e massa seca da parte aérea. Foram utilizados os indicadores econômicos: renda bruta, renda líquida, taxa de retorno e índice de lucratividade na avaliação econômica das culturas. A maior performance agroeconômica da cenoura foi obtida na quantidade de 45 t ha-1 de flor-de-seda incorporada ao solo no parcelamento de 30% quinze dias DAS + 70% trinta dias DDS. O melhor desempenho agroeconômico da rúcula foi obtido na quantidade de 19 t ha-1 de flor-de-seda incorporada ao solo no tempo de 20 dias antes da sua semeadura. O cultivo do coentro foi agroeconomicamente inviável em função das quantidades de flor-de-seda incorporadas ao solo e de seus tempos de incorporação estudados
Produção de cultivares de milho em função de adubações e espaçamentos entre linhas
Authors:   , Alves Anailson de Sousa
Published: November 2024

O potencial produtivo da cultura do milho pode ser explorado pela implementação criteriosa de aspectos técnicos, como a escolha da cultivar que melhor se adapta às condições de cultivo, espaçamento utilizado e o manejo adequado. Objetivou-se avaliar o desempenho agronômico, os componentes de produção e a produtividade de duas cultivares de milho em função dos tipos de adubações e espaçamentos entre linhas, em sistema de cultivo irrigado. O experimento foi realizado na Fazenda Experimental Rafael Fernandes, em Mossoró, RN, adotando-se o delineamento em blocos casualizados, no esquema fatorial 3 x 2 x 2, com quatro repetições, sendo os tratamentos constituídos por três adubações (AO - Adubação Orgânica; AOM - Adubação Organomineral e AM - Adubação Mineral), duas cultivares de milho (Bras 3010 e Potiguar) e dois espaçamentos entre linhas (80 cm e 50 cm). Foram avaliados o índice de velocidade de emergência, população inicial e final de plantas, altura de inserção de espigas, diâmetro do colmo, número de fileiras de grãos por espiga, número de grãos por espiga, massa de espiga com e sem palhas, diâmetro, comprimento e massa de grãos por espiga e produtividade. A adubação organomineral (AOM) não apresentou diferenças significativas em relação à adubação mineral (M) nos parâmetros desempenho agronômico das cultivares de milho avaliadas, com exceção do diâmetro do colmo. Os aspectos agronômicos das cultivares de milho avaliadas foram incrementados com a utilização do espaçamento de 80 cm entre linhas, com exceção da população inicial e final de plantas. A maior produtividade foi encontrada com a utilização da adubação orgânica, para a cultivar Potiguar, no espaçamento de 80 cm entre linhas. A população final, a produtividade e a massa de mil grãos foram os componentes que mais influenciaram na avaliação do conjunto dos dados. Cada cultivar de milho avaliada respondeu de maneira diferenciada às adubações e espaçamentos avaliados. A concordância entre os resultados da análise de agrupamentos e da análise de componentes principais com a análise de variância evidencia a adequação das técnicas estatísticas multivariadas utilizadas nesta pesquisa. O uso combinado das técnicas multivariadas possibilitou inferir com maior segurança nos agrupamentos formados entre os tratamentos e em suas características
Necessidades hídricas das culturas milho e feijão-caupi influenciadas pelas mudanças climáticas no semiárido nordestino
Authors:   , Cavalcante Junior Edmilson Gomes
Published: November 2024

O objetivo geral do presente trabalho foi verificar os impactos que as mudanças climáticas podem provocar sobre o desenvolvimento e a evapotranspiração do milho e do feijão-caupi, no semiárido brasileiro. O trabalho foi desenvolvido nos municípios de Apodi, Ipanguaçu e Mossoró, pertencentes ao estado do Rio Grande do Norte. A determinação da evapotranspiração da cultura, em suas diferentes fases, foi realizada através de lisímetros de pesagem. Para verificar a influência das mudanças climáticas sobre o consumo hídrico da cultura foram simuladas alterações na temperatura e na umidade relativa do ar, através do modelo climático PRECIS. Foram avaliados dois cenários de emissões baseados no relatório do IPCC (Intergovernmental Panel on Climate Change): um pessimista denominado A2 e um otimista B2. O coeficiente de cultivo do milho sofreu maior influência das mudanças climáticas, pois a cultura apresenta um porte mais elevado, em comparação com a cultura de referência, com isso, suas propriedades aerodinâmicas foram mais influenciadas pela redução da umidade relativa simulada pelo modelo. As temperaturas ficarão muito acima do limite tolerado pelas culturas, o que poderá repercutir negativamente no seu desenvolvimento e consequentemente no rendimento. Com o aumento nas temperaturas, ambas as culturas terão seus ciclos reduzidos. A redução no ciclo também provocará uma diminuição na evapotranspiração total das culturas. Com os acréscimos esperados na temperatura do ar e a redução na umidade relativa, a taxa diária da evapotranspiração ficará maior e apresentará efeito direto sobre os sistemas de irrigação, pois mesmo ocorrendo uma redução na evapotranspiração total, necessitarão de uma maior intensidade de irrigação para atender a demanda diária das culturas
Advanced Lung Disease Detection: CBAM-Augmented, Lightweight EfficientNetB2 with Visual Insights
Authors: Godbin A. Beena , Jasmine S. Graceline
Published: November 2024

Introduction:

This paper presents a multichannel deep-learning method for detecting lung diseases using chest X-ray images. Using EfficientNetB0 through
EfficientNetB7 pretrained models, the methodology offers improved performance in classifying COVID-19, viral pneumonia, and normal chest Xrays.

Methods:

The EfficientNetB2 model was customized by incorporating Squeeze-and-Excitation (SE) blocks and the Convolutional Block Attention Module
(CBAM) to improve the model's attention mechanisms. Additional convolutional layers were added for improved feature extraction, and multiscale
feature fusion was implemented to capture features at different scales.

Results:

In this study, 99.3% of the unseen chest X-ray images were identified using the proposed model. It demonstrated superior performance, surpassing
existing techniques and highlighting its robustness and generalizability on unseen data samples.

Conclusion:

Moreover, visualization techniques were used to inspect the intermediate layers of the model, providing deeper insights into its processing and
interpretation of medical images. The proposed method offers healthcare radiologists a valuable tool for rapid and accurate point-of-care diagnoses.
Smartphone App for Improving Self-Awareness of Adherence to Edoxaban Treatment in Patients With Atrial Fibrillation (ADHERE-App Trial): Randomized Controlled Trial (Preprint)
Authors: Yoon Minjae , Lee Ji Hyun , Kim In-Cheol , Lee Ju-Hee , Kim Mi-Na , Kim Hack-Lyoung , Lee Sunki , Kim In Jai , Choi Seonghoon , Park Sung-Ji , Hur Taeho , Hussain Musarrat , Lee Sungyoung , Choi Dong-Ju
Published: November 2024

BACKGROUND

Adherence to oral anticoagulant therapy is essential to prevent ischemic stroke in patients with atrial fibrillation (AF).

OBJECTIVE

This study aimed to evaluate whether smartphone app–based interventions improve medication adherence in patients with AF.

METHODS

This open-label, multicenter randomized controlled trial (ADHERE-App [Self-Awareness of Drug Adherence to Edoxaban Using an Automatic App Feedback System] study) enrolled patients with AF treated with edoxaban for stroke prevention. They were randomly assigned to app-conditioned feedback (intervention; n=248) and conventional treatment (control; n=250) groups. The intervention group received daily alerts via a smartphone app to take edoxaban and measure blood pressure and heart rate at specific times. The control group received only standard, guideline-recommended care. The primary end point was edoxaban adherence, measured by pill count at 3 or 6 months. Medication adherence and the proportion of adequate medication adherence, which was defined as ≥95% of continuous medication adherence, were evaluated.

RESULTS

Medication adherence at 3 or 6 months was not significantly different between the intervention and control groups (median 98%, IQR 95%-100% vs median 98%, IQR 91%-100% at 3 months, P=.06; median 98%, IQR 94.5%-100% vs median 97.5%, IQR 92.8%-100% at 6 months, P=.15). However, the proportion of adequate medication adherence (≥95%) was significantly higher in the intervention group at both time points (76.8% vs 64.7% at 3 months, P=.01; 73.9% vs 61% at 6 months, P=.007). Among patients aged >65 years, the intervention group showed a higher medication adherence value and a higher proportion of adequate medication adherence (≥95%) at 6 months.

CONCLUSIONS

There was no difference in edoxaban adherence between the groups. However, the proportion of adequate medication adherence was higher in the intervention group, and the benefit of the smartphone app–based intervention on medication adherence was more pronounced among older patients than among younger patients. Given the low adherence to oral anticoagulants, especially among older adults, using a smartphone app may potentially improve medication adherence.

CLINICALTRIAL

International Clinical Trials Registry Platform KCT0004754; https://cris.nih.go.kr/cris/search/detailSearch.do?seq=28496&search_page=L

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2021-048777
The Use of Machine Learning in Real-World Data: A Systematic Review of Disease Prediction and Management (Preprint)
Authors: Alhumaidi Norah Hamad , Dermawan Doni , Kamaruzaman Hanin Farhana , Alotaiq Nasser
Published: November 2024

BACKGROUND

Machine learning (ML) and big data analytics are revolutionizing healthcare, particularly in disease prediction, management, and personalized care. With vast amounts of real-world data (RWD) from sources like electronic health records (EHRs), patient registries, and wearable devices, ML offers significant potential to improve clinical outcomes. However, data quality, transparency, and clinical integration challenges remain.

OBJECTIVE

This study aims to systematically review the use of ML in real-world data for disease prediction and management, identifying the most common ML methods, disease types, study designs, and sources of real-world evidence (RWE).

METHODS

A systematic review followed the PRISMA guidelines to identify studies that utilized machine learning methods for analyzing real-world data in disease prediction and management. The review focused on extracting data related to the machine learning algorithms used, disease categories, types of studies, and sources of RWE, such as electronic health records (EHRs), patient registries, and wearable devices.

RESULTS

The systematic review revealed that the most frequently employed machine learning methods were Random Forest (RF), Logistic Regression (LR), and Support Vector Machine (SVM). These methods were applied across various disease categories, with cardiovascular diseases, cancers, and neurological disorders being the most common. Real-world evidence primarily originated from EHRs, patient registries, and wearable devices, with a predominant focus on predictive modeling to improve clinical outcomes.

CONCLUSIONS

ML and big data hold significant promise for enhancing healthcare through better disease prediction and management. However, data quality, model interpretability, and generalizability must be addressed to integrate ML models fully into clinical practice.
Not Merely Interpretative
Authors: Macfarlane Emmett
Published: November 2024

In this paper, I argue that the Supreme Court's interpretation of section 25 of the Charter in Dickson v VGFN establishes an important precedent that may encourage the courts to reverse the jurisprudential trend against a proper interpretation of section 28, which is currently at issue in the Bill 21 case. I argue that both provisions — section 25 and section 28 — share key features, in that that although they do not establish freestanding rights, they are nonetheless of substantive import. Both provisions operate to condition, and even negate or block, the application of other sections of the Charter. In this sense, the tendency among commentators to characterize these provisions as either standalone rights guarantees or merely interpretative provisions is a false dichotomy. Indeed, a middle ground between these two options is precisely what the majority of the Court has now determined with respect to section 25, a reality that opens an obvious jurisprudential door to a similar reading of section 28.
Clinical comparison of unilateral biportal endoscopic technique with interlaminar microdiscectomy for single-level lumbar discectomy: a prospective study
Authors: Balan V.S. , Kravchuk L.D. , Fishchenko I.V.
Published: November 2024

Background. Positive clinical outcomes of microdiscectomy vary in the range from 75 to 80 %. However, the share of unsatisfactory results with more than 2-year follow-up is 38 %, and with 8-year follow-up it reaches 40 %. To avoid postoperative fibrosis, which in the future may require repeated surgical intervention, and to improve the outcomes of surgical treatment for disc herniations, the traumatic approach is to be reduced. In this regard, endoscopic lumbar discectomy is the least invasive direct decompression technology and a promising direction of surgical treatment for herniated intervertebral discs. Materials and methods. A prospective study was conducted on the basis of the neurosurgery department of the spine and spinal cord of the Ivano-Frankivsk Regional Clinical Hospital. The criteria for intergroup distribution were the methods of surgical treatment: patients of the first group (n = 57) underwent removal of a herniated intervertebral disc by the method of unilateral biportal endoscopic discectomy, participants of the second group (n = 60) underwent open interlaminar microdiscectomy. Results. No significant differences were found in the intergroup comparison according to the Oswestry Disability Index at all stages. The duration of surgery when using endoscopic access averaged 41 minutes [38.5; 44.75] vs 60 min [57.5; 69.65] with microdiscectomy, the difference is statistically significant (р ≤ 0.01). The volume of blood loss was 2.3 times less during endoscopic access — 53.1 ± 19.7 ml and 121.5 ± 18.4 ml (р < 0.05). As expected, the length of stay in the hospital was shorter in the endoscopic discectomy group — 2 days [1; 3] versus 4 days [3; 6] in the microdiscectomy group (p ≤ 0.05), which is associated with early activation of patients, less pain syndrome, correspondingly smaller size of postoperative wound and no need for wound care. Conclusions. The results of our research showed the potential advantages of unilateral biportal endoscopic discectomy over interlaminar microdiscectomy.
Features of hemostasis in patients with hemophilic arthropathy of the knee joint in the perioperative period
Authors: Averianov Ye.V. , Shkrebko V.O.
Published: November 2024

Background. Today, hemophilia is considered a hematological-orthopedic disease that develops as a result of damage to various anatomical structures of the musculoskeletal system among which the synovial joints, the so-called target joints, dominate in almost all patients with hemophilia. The aim of our study was to analyze the influence of the level of coagulation factors in patients with hemophilic arthropathies of the knee joint in different periods of surgical treatment. Materials and methods. To carry out our research, we analyzed data from 77 patients with hemophilia who underwent inpatient and outpatient treatment at the MNPE “Kyiv City Clinical Hospital 9” from 2008 to 2022. The first group included 43 (55.8 %) patients who underwent surgical synovectomy. The second group comprised 34 (44.2 %) patients who underwent total knee arthroplasty. Results. In our study, the coagulation factor level in the preoperative period was 1.66 ± 0.15 IU/ml in the first group, and 1.83 ± 0.15 IU/dl in the second group. Before surgery, all patients were administered coagulation factor VIII at a dose of 50 IU/kg of body weight. As a result, during surgery, the coagulation factor level was 92.6 ± 2.0 IU/dL in the first group, and 98.5 ± 2.2 IU/dL in the second group. These mean levels of factor VIII deficiency are a typical predicted response to administration of recombinant factor VIII concentrate. Such content of coagulation factor VIII corresponded to the normal level of coagulation factor VIII during surgery and did not require intraoperative correction. In the postoperative period, there was a significant decrease in the level of coagulation factor VIII to 69.3 ± 1.4 IU/dl in patients of the first group and 75.3 ± 1.5 IU/dl in the second group. Such a drop in the postoperative period is natural, taking into account the typical pharmacokinetics of coagulation factor VIII preparations in patients with hemophilia. Conclusions. Given the obtained indicators of coagulation factor VIII, as well as the peculiarities of the pharmacokinetics of its recombinant drug, patients of both observation groups were administered a maintenance dose of 25 IU/kg in the postoperative period.
Exploring "Preventive Treatment" Strategies for Childhood and Adolescent Obesity Based on Traditional Chinese Medicine's Concept of Preventing Disease Before It Occurs
Authors: Cao Jiarui , Zhang Xinghai
Published: November 2024

The concept of "preventive treatment" in Traditional Chinese Medicine (TCM) is a profound summary of the preventive aspects of TCM, holding significant implications for both disease prevention and treatment. This paper applies the principles of "preventive treatment" to address obesity issues among children and adolescents, exploring specific prevention and intervention strategies from three perspectives: preventing disease before it occurs, preventing progression in existing conditions, and preventing recurrence after recovery.
Research on the Design and Promotion of Macau City Brand Image
Authors: Pei Wen
Published: November 2024

With the deepening of globalization, the shaping and promotion of Macao's city brand has become increasingly important in enhancing international recognition, attracting external investment and tourists, and enriching the local economic structure. This paper focuses on the design and promotion of Macao city brand image, and discusses its challenges and strategies in cross-cultural communication, the role of government, and the evaluation and feedback mechanism of brand promotion. The paper analyzes the difficulties encountered in the cross-cultural communication of Macao brand image and puts forward the localization promotion strategies for different markets. The need for government leadership and policy support in brand promotion is also discussed in detail and the importance of establishing evaluation indicators and user feedback mechanisms to ensure the effectiveness and continuous improvement of brand promotion is proposed.
A persecução penal dos crimes dos poderosos na América Latina: um estudo comparado entre Brasil e Chile
Authors: Falavigno Chiavelli Facenda , González-Guarda Claudio
Published: November 2024

This article draws on the theoretical framework of the Crimes of the powerful to analyze the political and criminal reactions generated by high-profile events involving this type of criminality in two Latin American countries, Chile and Brazil. The specific events are the so-called case of collusion of pharmacies and of fraudulent party financing in Chile, and in Brazil, the events that will result in the Lava Jato Operation. This is a qualitative investigation. The methodologies used will be case studies and comparative analysis. The main question is: what is the political-criminal reaction adopted by each country and its consequences? The main objective of the research is to verify similarities and differences between what happened in the two countries, and to ascertain the main reasons why, in Brazil, the window of opportunity was not used to make effective and structural changes in dealing with the phenomenon. The article is divided into the following stages: a) definition of the main characteristics of the criminality of the powerful and the difficulties in theorizing, mapping and dealing with it; b) a brief description of what happened in Chile and Brazil, respectively; c) a comparative analysis of the main differences between the political criminal reactions in the two countries, as well as their possible explanations.
Digital Evidence Barriers Overcoming in the Ukrainian case: New Actors and Standards
Authors: Valery Shepitko , Shepitko Mykhaylo , Latysh Kateryna
Published: November 2024

The purpose of this article is to examine the evolving landscape of joint investigative efforts (public and private), with a particular focus on new actors, and the emerging importance of digital evidence collection in conflict zones. It addresses the role of civil society organizations (CSOs) in collecting evidence, analyzing this from historical and legal perspectives. The article discusses the integration of collected digital evidence into ongoing investigations, highlighting the practical obstacles encountered. It also presents case studies where CSOs have intervened when state authorities failed to effectively investigate core international crimes, showcasing how these organizations contribute to modernizing investigative mechanisms using technology. As digital technology becomes increasingly central to criminal activity law enforcement bodies are challenged to adapt their investigative techniques to this new digital landscape. This article suggests opportunities for cooperation between public organizations and law enforcement agencies and emphasizes the importance of interdisciplinary cooperation to keep pace with the evolution of the digital criminal landscape. The article uses a combination of general scientific and specialized methods. The results highlight the importance of continued innovation and interdisciplinary collaboration, and policy development for better frameworks and cooperation.
Improving Conversational AI using Transformer and Reinforcement Learning from Human Feedback (RLHF)
Authors: Patil Satchal Y. , Shrikhande Prof. Rohini
Published: November 2024

Abstract: The integration of transformer models and Reinforcement Learning from Human Feedback (RLHF) has significantly advanced the field of conversational AI. Transformer models, with their multi-head attention mechanisms, enable AI to understand complex language patterns and maintain context across long conversations, a key limitation in earlier models like RNNs. This advancement has transformed AI systems such as ChatGPT, allowing for more coherent and contextually accurate responses. RLHF introduces a critical feedback loop where human evaluators guide the model’s learning by providing feedback on the quality of its responses. This method ensures that conversational AI not only produces technically correct outputs but also aligns with human values, reducing the risk of harmful, biased, or irrelevant responses. RLHF enables continuous improvement of AI systems by incorporating real-world human preferences into the model’s training process. By combining the scalability of transformer models with the ethical alignment offered by RLHF, conversational AI has become more reliable, efficient, and adaptable to real-world applications. This combination has revolutionized industries such as customer service, education, and healthcare, where AI-driven dialogue systems are increasingly essential for automating tasks and enhancing user experiences.
Evaluating Financial Inclusion through PMJDY: A Case Study of Barachh Village
Authors: Garg Saurabh
Published: November 2024

Abstract: One of the innovative steps taken to shove financial incorporation within India is an enterprise called Pradhan Mantri Jan Dhan Yojana (PMJDY ) which was started in the year 2014. The main aim is to make sure that common reach to bank services with at least one primary bank account per household. With the offering of zero-balance accounts, PMJDY made banking reach even the most backward sections of society: people living in village areas and having low incomes. The scheme is significant in terms of bringing millions into the formal banking system, who were earlier financially excluded. Moreover, the PMJDY has facilitated the use of government subsidies and benefits that can be deposited directly into the accounts of intended beneficiaries, thus reducing leakages and ensuring that the intended recipients have availed the support entitled to them. The scheme also propagates a move toward digital payments with the end goal of making people financially literate enough to become more inclusive toward participating in the economy. The research has been conducted and tries to discover the success rate and awareness level of the inclusion process in Barachh Village, situated in the Shahdol district. The study has collected both primary and secondary data concerning the bank accounts opened under the scheme. The financial inclusion process of PMJDY and its socio-economic backgrounds are linked through the use of percentage and graphical methods.
Recent Advancement In Nanocarrier Systems For Cancer Targeting
Authors: Teron Charlisar , Choudhury Ananta , Hoque Nurjamal
Published: November 2024

Cancer is a disease that has a complicated pathological process. Current chemotherapy has issues such as lack of selectivity, cytotoxicity, generation of multi-drug resistance, and the formation of stem-like cells. The novel treatment modalities enabled by nanomaterial characteristics have expanded their reach in cancer therapy beyond traditional medication delivery. Nanotechnology has been actively researched and used in cancer treatment because nanoparticles can serve as an effective medication delivery mechanism. Nanoparticle-based drug delivery provides distinct benefits over traditional drug administration, including greater stability and biocompatibility, increased permeability and retention effect, and precision targeting. There are numerous major categories of nanomaterials utilized in cancer treatment. These nanomaterials, which target cancer cells, the tumor microenvironment, and the immune system, have been modified for a variety of cancer treatments in order to overcome toxicity and lack of selectivity, as well as to improve drug capacity and bioavailability. Furthermore, nanoparticle-based drug delivery systems have been found to help overcome cancer-related treatment resistance. In cancer therapy, nanoparticles can be used to encapsulate active pharmacological substances and deliver them to the tumor location more efficiently. This overview lists the several types of nanoparticles that have been tested in clinical trials for cancer therapy. Furthermore, the most recent advancements in the use of nanoparticles in cancer therapy are emphasized.The literature for this study was compiled using databases such as PubMed, Google Scholar, and ScienceDirect on nanoparticles in the treatment of cancer have been collected. The present article focuses on nanotechnology advancements, specifically nanocarriers for anticancer medication delivery. It covers nanoparticles, polymeric micelles, dendrimers, hydrogels system and finally the future prospects of the nanocarrier.
LOCALIZATION OF ALKALOIDS AND TANNINS FROM AERIAL PARTS OF FICUS ARNOTTIANA (MIQ.) MIQ.
Authors: Chilka Rajeswari , Ameena Sultana , Isnagari Phaneendra , Sulega Apoorva
Published: November 2024

The medicinally important plant Ficus arnottiana (Miq.) Miq. belongs to the family ‘Moraceae’ have been used extensively by ayurvedic practitioners in India to treat various ailments. The objective of this work was to contribute to the pharmacognostic standardization of F.arnottiana. Microscopic analysis of leaf, petiole and stem showed the presence of alkaloids, tannins, starch, protein and lipids. The leaf section shows distinct character of double layer of epidermis and a cylinder of vascular bundles in the midrib region which was not observed in the related species of F. cyclophylla and F. elliotiana. The F. cyclophylla and F. elliotiana the vascular bundles are discreet. Petiole section shows 4 to 5 distinct crescent shaped vascular bundles. Therefore, from the identified features, it proves useful forthe diagnosis of the species which, together with identification of the chemical compounds and its histo-localization, provides support to their quality control.
RP-HPLC Method for Determination of Imeglimin Hydrochloride in Bulk and Tablet Formulation
Authors: Mubeen G  , Navali Sharanabasava , N Lalitha
Published: November 2024

Imeglimin hydrochloride (IMEG.HCl) is a new tetrahydro triazine-containing class of oral antidiabeticagents referred to as ‘glimins’, is used to treat type 2 diabetes (T2D). It is the firstanti-diabetic drug of this type to receive approval. It is an inhibitor of oxidative phosphorrylation that also works to improve muscle glucose absorption and restore regular insulin secretion1. A reverse phase HPLC method was developed and validated for quantitative determination of Imeglininhydrochlorideusing a BRISA LC2 C18 (25 mm x 0.46 mm, 5µm) Column, isocratic mobile phase of Methanol: Phosphate buffer (10mM) pH6.0, at a flow rate of 1ml/min. The analyte was monitored at 243nm and retention time was found to be 3.097min.The peak obtained was symmetrical with tailing factor less than 2 and theoretical plates more than 2000. The developed HPLC method showed good linearity (R2=1), the intra- and inter-day precision was less than 2%, LOD and LOQ were 0.137 and 1.417 μg/ml andaccuracy for three different levels was found to be 101.23%w/w-100.83%w/w respectively.The method was validated in accordance with ICH guidelines Q2 (R1).2 and was found to be Specific, Accurate, Precise, Robust and can be successfully applied for routine analysis of Imeglininhydrochloridein bulk and in pharmaceutical dosage form.
Critical Review on Pongamia Pinnata: A Versatile Medicinal Plant
Authors: Vidhale Deepika Kyatham , Vamshi Reddy Mora  , Sairam Pasam  , Aishwarya Kotha  , Konda Ujwala , Narender Boggula
Published: November 2024

The word herb, as used in herbal medicine, is also known as botanical medicine or as phytotherapy or phytomedicine which means a plant or plant part is used to make medicine to assist in the healing process during illness and disease. So, there are many herbal remedies individually or in combination have been recommended in various medicinal treatises for the cure of different diseases.Pongamia pinnata (L.) Pierre is a tree native to Southeast Asia. Recently, interest in Pongamia pinnatafocused on its potential as a biofuel source as its seeds contain around 40% oil. However, Pongamia pinnata has multiple applications beyond biofuel production. Pongamia pinnatacan also bring socio-economic benefits as its ability to restore degraded and contaminated land provides opportunities for local communities through novel valorisation pathways. These multiple applications have potential to form part of a circular bioeconomy in line with sustainable development goals.Pongamia pinnata has a large number of applications, and among those, its medicinal value has been recognised for decades with its roots in Ayurvedic medicine and comprehensive information on Pongamia pinnata medicinal uses, phytochemistry, and pharmacology can be found.The literature covering the multiple applications of Pongamia pinnatais vast and it is beyond the scope of this study to review it in detail.Therefore, the present review aimed to compile up to date and comprehensive information of Pongamia pinnata with special emphasis on its phytochemistry, various scientifically documented pharmacological activities, traditional and folk medicine uses alongwith its role in biofuel industry.
PRODUÇÃO DE LEITE NO BRASIL, MINAS GERAIS E MESORREGIÃO DO ALTO PARANAÍBA: Uma breve revisão narrativa de literatura
Authors: Jesus Lorena Rosa de , Vieira Paulo Rufino Paulino , Pereira Saulo Gonçalves , Oliveira Nayara Maria de
Published: November 2024

Brazil leads the ranking as the sixth largest milk producer in the world. In view of the above, the present study aimed to evaluate the results published in the literature about the evolution of Brazilian milk production, world production, Brazilian production, Minas Gerais milk production between the years 2014 and 2023. The present study is characterized by being a narrative type review whose general objective is to discuss the importance of knowledge about milk production in the world, in Brazil and in the state of Minas Gerais. Then, after the process of choosing and defining the theme, a bibliographic survey was carried out on the Google Scholar digital platform. For the search, we used the words: milk, milk production chain, dairy basin, milk producers, literature review, narrative review. Articles and online magazines in Portuguese were considered and the priority was the database. Subsequently, we carried out a reading analysis of the selected articles, considering the common and divergent points in the approaches of the authors consulted. Based on the existing bibliography, it was possible to conclude that both global and Brazilian dairy productivity and that of the Triângulo Mineiro / Alto Paranaíba mesoregion have been evolving over the years, due to the adoption of technologies by the sector. Between 2014 and 2023 there was an increase of 0.36% in national production, in the last 9 years the number of cows milked has decreased and national productivity has increased by around 70%, elucidating the period of momentum of new technologies that livestock farming of milk has been experiencing.
¿Desde casa o de vuelta a la oficina? Un análisis de los discursos y percepciones sociales sobre el teletrabajo tras el fin de la pandemia
Authors: Yrazusta Arango Juan , Fernández Rodríguez Carlos J.
Published: November 2024

Este artículo tiene como objetivo valorar las percepciones sociales y discursos de empleados en relación con el teletrabajo. La pandemia de la COVID-19 supuso una explosión en el recurso al teletrabajo, una vez que los confinamientos y la promoción de la distancia social obligaron a muchas organizaciones a fomentar el trabajo desde el hogar; no obstante, tras el fin de la emergencia sanitaria, algunas empresas y administraciones han retomado progresivamente la presencialidad. ¿Cuál es la percepción de los empleados sobre el teletrabajo en este momento de transición de vuelta a la oficina? Este artículo se centra en esta cuestión mediante el análisis de los discursos de empleados de diversos sectores con relación al teletrabajo, recogidas a partir de una serie de entrevistas realizadas a trabajadores de la Comunidad de Madrid a finales del año 2023 que trabajan de forma parcial o total bajo esta modalidad. Los resultados muestran que entre los empleados hay una preferencia porque se mantenga el modelo híbrido, una vez que les permite conciliar mejor con la vida personal y les permite alcanzar una flexibilidad más cercana a la realmente deseada por ellos. El análisis realizado indica posibles incrementos de la productividad, debido no solo a una mayor motivación y satisfacción percibidas por el empleado, sino también al alargamiento e intensificación de la jornada laboral al trabajar desde su hogar. Adicionalmente, el debate en torno al teletrabajo sugiere una disputa en torno a la idea de flexibilidad empresarial, una vez que empleados y dirección de las empresas parecen estar manejando perspectivas distintas respecto a la misma.
Construction of perfect tensors using biunimodular vectors
Authors: Rather Suhail Ahmad
Published: November 2024

Dual unitary gates are highly non-local two-qudit unitary gates that have been studied extensively in quantum many-body physics and quantum information in the recent past. A special class of dual unitary gates consists of rank-four perfect tensors that are equivalent to highly entangled multipartite pure states called absolutely maximally entangled (AME) states. In this work, numerical and analytical constructions of dual unitary gates and perfect tensors that are diagonal in a special maximally entangled basis are presented. The main ingredient in our construction is a phase-valued (unimodular) two-dimensional array whose discrete Fourier transform is also unimodular. We obtain perfect tensors for several local Hilbert space dimensions, particularly, in dimension six. A perfect tensor in local dimension six is equivalent to an AME state of four qudits, denoted as AME(4,6). Such a state cannot be constructed from existing constructions of AME states based on error-correcting codes and graph states. An explicit construction of AME(4,6) states is provided in this work using two-qudit controlled and single-qudit gates making it feasible to generate such states experimentally.
Teatro: a arte imortal
Authors: Bodnar Roseli , Silva Odi A. Rocha da , Almeida Juliana Santana de , Schwertner Marcia Regina
Published: November 2024

A expressão teatral constitui uma das linguagens marcantes da arte. Desde a Grécia antiga até as incursões pelos registros da História, o teatro tem levado a humanidade à reflexão. A matéria-prima do pensamento teatral são as palavras e a expressão corporal. Sua ressonância tem se eternizado ao longo dos tempos não apenas pelo que transmite performaticamente, mas pelas marcas de reflexão sobre a natureza humana, as quais conseguiu indelevelmente imprimir na história do pensamento ocidental. A presente publicação intenta registrar reflexões críticas acerca do teatro nos mais diversos momentos e circunstâncias. Cada uma das abordagens busca refletir sobre o teatro sobretudo como expressão de questões humanas que perpassam os séculos. O tempo passa, mas a natureza humana segue sendo a mesma em suas tendências, emoções e demais particularidades. Neste sentido, o livro apresenta várias abordagens. Não se pretende seguir aqui uma ordem cronológica de fatos e produções literárias. Cada um dos articulistas buscou refletir, dentro da sua linha de pesquisa e sua especialidade, acerca de elementos atinentes à produção teatral em várias épocas.
Regional Autonomy and Special Autonomy: A Review of Integration in Regional Governance from the Perspective of Civic Education
Authors: Sunarso Sunarso , Dewi Puspitasari Chandra , Hidayah Yayuk , Firmansyah Akmal
Published: November 2024

This study addresses the challenges and impacts of Regional and Special Autonomy in local governance, with a particular focus on the role of civic education. The central problem is understanding how these autonomy concepts influence local development and citizen participation.The objectives of this research are to analyze how Regional and Special Autonomy affect societal dynamics and local development, and to assess the role of civic education in enhancing the implementation of these concepts. A literature study approach was employed to gain a comprehensive understanding of the issue. The analysis involved reviewing a diverse range of sources, including legal documents, academic journals, and research reports. The study utilized a variety of literature sources relevant to Regional and Special Autonomy and civic education, providing a broad and deep examination of the subject matter.The findings highlight that a thorough understanding of Regional and Special Autonomy is crucial within civic education frameworks. Effective implementation of these autonomy concepts at the local level can foster greater citizen participation in development and decision-making. Additionally, civic education plays a critical role in preparing citizens to understand and engage with their rights and responsibilities, thereby supporting more inclusive and sustainable governance. The study concludes that integrating Regional and Special Autonomy with civic education is essential for enhancing local governance. A better grasp of these concepts, supported by robust civic education, can lead to more democratic, inclusive, and sustainable community development.
AUTOFICÇÃO DO PRESENTE
Authors: Lírio Gabriela
Published: November 2024

Neste artigo, analiso a produção discente a partir de trabalhos artísticos desenvolvidos em sala de aula na pandemia e exibidos na Internet, orientados por mim em disciplina de graduação. Para isso, desenvolvo o conceito de autoficção do presente, defendendo que grande parte da produção cênica em momento pandêmico reflete a vivência do presente traumático, diante da elaboração do luto coletivo de mais de 500 mil brasileiros vitimados pela covid-19. Parto do pressuposto de que a situação política trágica no Brasil, acentuada pelo negacionismo, pela ausência de política sanitária e demais políticas públicas, incluindo o setor cultural e/ou educacional, corrobora para ampliar o sentimento de desalento e melancolia (BIRMAN, 2020), provocando a emergência de investigações ancoradas em experiências autoficcionais, que não se referem ao passado, mas ao presente, constituindo o testemunho da memória traumática, por meio da elaboração artística na vivência dos acontecimentos.
NOÇÕES DE INFÂNCIAS, TEATRO INFANTIL E ABORDAGENS CONTEMPORÂNEAS
Authors: Campos de Oliveira Freire Brenda , Souza Bortolini Neide das Graças de , Santos Clóvis Domingos dos
Published: November 2024

Este artigo articula algumas noções de natureza sócio-histórica, educacional e psicanalítica de “infância” que determinam atividades artístico-culturais na contemporaneidade. Tais perspectivas, ao passo que revelam a complexidade do “teatro infantil”, incidem sobre a concepção plural de “infâncias”. A partir do estudo de um possível “teatro para as infâncias”, são abordadas algumas experiências cênicas realizadas, entre 2014 e 2017, em Belo Horizonte.
OPERAÇÃO E COMUNICAÇÃO DA CRÍTICA DE DANÇA
Authors: Rochelle Meneghini Henrique
Published: November 2024

A crítica de dança é uma atividade de mediação, realizada por quatro operações — Descrição, Interpretação, Avaliação e Contextualização —, que resultam em dois efeitos, aqui chamados Prolongamento e Deslocamento da experiência estética. Operações e efeitos são analisados a partir de reflexões conceituais, e em exemplos práticos, colhidos de oito textos de críticas sobre versões distintas do balé O Quebra Nozes, ilustrando como se organiza e como opera a crítica de dança.
VIDA E PLASTICIDADE EM CENA
Authors: Almeida Zaltronn Michele
Published: November 2024

Muito já foi escrito e ainda se fala das divergências existentes entre Konstantin Stanislávski e Vsévolod Meyerhold e, certamente, elas existiram. Em vários momentos, discordâncias no que concerne ao pensamento e à prática da criação cênica os levaram, de fato, a extremidades opostas. Mas, neste artigo, trato sobretudo das confluências de ideias e de buscas criativas entre esses grandes mestres do teatro. Longe de desconsiderar ou tentar diminuir a complexidade dessa relação, procuro ressaltar momentos de convergência, os quais se intensificaram nos anos finais de vida de ambos os artistas.
ENSINO DE ARTE E EDUCAÇÃO ANTIRRACISTA
Authors: Jarbas Siqueira Ramos  , Talita de Barros Lima Siqueira
Published: November 2024

Este trabalho tem como objetivo elaborar algumas considerações acerca da relação entre o ensino de Arte e a educação antirracista, buscando problematizar as questões políticas e pedagógicas relacionadas à implementação dos conteúdos da educação étnico-racial nos currículos e nas práticas educacionais brasileiras, bem como assinalar possíveis caminhos para a produção de uma educação antirracista e decolonial, tendo como ponto de partida o campo das artes.
TEATRO COMO INSTRUMENTO DE TRANSFORMAÇÃO SOCIAL:
Authors: Toledo Magdalena Sophia
Published: November 2024

Este artigo propõe uma reflexão sobre a Oficina de Teatro Livre e a Oficina para Formação de Atores da Escola de Teatro Popular do grupo Ói Nóis Aqui Traveiz de Porto Alegre. A partir de uma perspectiva etnográfica, através da observação participante centrada na convivência com o grupo, procuro identificar de que modo as práticas pedagógicas do grupo contribuem para uma ampliação dos sentidos e das possibilidades de um teatro político.
CONSIDERAÇÕES PARA O PROJETO POLÍTICO-PEDAGÓGICO DE UM TEATRO POSSÍVEL
Authors: Telles Sérgio
Published: November 2024

Este trabalho discute uma proposta de ensino do teatro com base nas práticas formativas do teatro de grupo da Zona Oeste da cidade do Rio de Janeiro onde, com raríssimas opções de acesso aos equipamentos e meios de produção cultural, a transmissão do conhecimento se realiza na prática artística. A partir de levantamento junto aos conjuntos locais, o artigo esboça um projeto pedagógico.
A Semantic Framework for Modular Knowledge Integration in Large Language Models
Authors: Etlune Kassandra , Richardson Sebastian , Howard Megan , Foster Benjamin , Russell Rosie , Murphy Daniel
Published: November 2024

The Adaptive Semantic Framework introduces a modular architecture for large language models, enabling dynamic integration of semantic components to enhance scalability and adaptability across diverse natural language processing tasks. By employing modular semantic units, the framework facilitates efficient knowledge incorporation, resulting in improved performance metrics such as accuracy and inference speed. Empirical evaluations demonstrate the framework’s resilience to noisy inputs, maintaining high accuracy levels and showing its robustness for real-world applications. Additionally, the framework’s capacity for domain adaptation without extensive retraining highlights its versatility and practical utility. The mathematical foundations of the framework provide a formal basis for modeling semantic modularity and integration, contributing to the theoretical understanding of large language model architectures. Comparative analyses with existing models establish the framework’s superiority, setting a new benchmark in the field. The scalability assessment reveals that the framework effectively manages computational demands, making it suitable for deployment in resource-constrained environments. Furthermore, the energy efficiency evaluation indicates a favorable balance between performance and power consumption, aligning with sustainable computing practices. Collectively, these contributions mark a substantial progression in the development of large language models, offering a robust foundation for future innovations in the field.