bluuebunny/crossref_metadata_2025 huggingface dataset:
Boccaccio y Dante en el Curial e Güelfa.
Authors: Butiñá Jiménez Julia
Published: January 2019

-
Estudio de algunas unidades lingüísticas designativas (2).
Authors: Otaola Olano Concepción
Published: January 2019

-
Sobre la fecha de Hipp. De Glandulis.
Authors: Rodríguez Alfageme Ignacio
Published: January 2019

-
Descripción fónica del habla de las Cinco Villas (Gredos).
Authors: Esgueva Martínez Manuel
Published: January 2019

-
Mito y lírica.
Authors: López Férez Juan Antonio
Published: January 2019

-
Innatismo: entre la lingüística y la filosofía.
Authors: Lledó Emilio
Published: January 2019

-
Algunos problemas de la traducción de la terminología onírica griega al castellano
Authors: Barrigón Fuentes María del Carmen , Nieto J. María
Published: January 2019

-
Lugar preferente de la novela corta en la literatura norteamericana.
Authors: Álvarez Calleja María Antonia
Published: January 2019

-
RESEÑAS de Textos teatrales hispánicos del siglo XVI
Authors: Baranda Nieves
Published: January 2019

RESEÑA de : Ferrer Valls, Teresa. Nobleza y espectáculo teatral : (1535-1622). Valencia :
UNED/Universidad de Sevilla/Universitat
de Valencia, 1993. RESEÑA de : Canet Vallés, José Luis. De la comedia humanística al teatro representable :
(Égloga de la tragicomedia de Calisto y Melibea, Penitencia de amor, Comedia Thebayda, Comedia Hipólita. Comedia
Serafina). Valencia : UNED/Universidad de Sevilla/Universitat de Valencia, 1993. RESEÑA de : Pérez Priego, Miguel
Ángel. Cuatro comedias celestinescas. Valencia : UNED/Universidad de Sevilla/Universitat de Valencia,
1993
Cuestiones lingüísticas sobre el texto oral.
Authors: Lamíquiz Ibáñez Vidal
Published: January 2019

-
Significación, aspectos y valores de las oraciones condicionales.
Authors: Deza Enríquez Ana Jimena
Published: January 2019

-
La poesía chilena emergente (1973-1985).
Authors: Lorente Medina Antonio
Published: January 2019

-
El despertar de la mujer norteamericana: creación de una estética feminista en The Awakening de Kate Chopin.
Authors: Álvarez Calleja María Antonia
Published: January 2019

-
Sobre San Juan de la Cruz y sobre la historia de las ideas literarias.
Authors: Abad Nebot Francisco
Published: January 2019

-
Escritoras de las minorías étnicas en Canada.
Authors: Gibert Maceda María Teresa
Published: January 2019

-
Transtextualidad y novela criminal: a propósito de Asesinato en Prado del Rey, de Vázquez Montalbán.
Authors: Valles Calatrava José R.
Published: January 2019

-
El apriorismo en la semantización y en el análisis del texto literario.
Authors: Quintana Docio Francisco
Published: January 2019

-
Notas sobre la ambición femenina como origen de la ambigüedad actancial en Anne Marie, de Lucien Bodard.
Authors: Soler Pérez Ana
Published: January 2019

-
Situación actual de la lengua francesa en la enseñanza primaria y secundaria dentro del territorio MEC.
Authors: Calvet Lora Rosa María
Published: January 2019

-
Psychosocial risk factors, organizational conflict and job satisfaction in Health professionals: A SEM model.
Authors: Sureda Elena , Mancho Javier , Sesé Albert
Published: January 2019

Objetivo: Poner a prueba un modelo de interdependencia sobre el efecto que los factores de riesgo psicosocial generan sobre el conflicto organizacional y la satisfacción laboral en profesionales sanitarios. Método: Se utilizó un diseño selectivo transversal con una muestra de 249 trabajadores de un hospital público. Los riesgos psicosociales se evaluaron mediante la herramienta F-PSICO, la variable conflicto organizacional fue operacionalizada mediante un conjunto de indicadores contenidos en una encuesta elaborada por un equipo multidisciplinar de profesionales sanitarios expertos en mediación laboral; y la satisfacción laboral fue medida con cuatro dimensiones del cuestionario Font Roja. El ajuste del modelo se estimó con modelos de ecuaciones estructurales. Resultados: Se obtuvo un ajuste adecuado del modelo, que supone que cuanto mayor es el riesgo psicosocial, mayor es el conflicto organizacional, y menor la satisfacción laboral percibida. También sitúa la conflictividad laboral como mediadora entre los riesgos psicosociales y la satisfacción laboral. Conclusiones: La contribución única del estudio aporta evidencias empíricas del papel de predictor directo de los riesgos psicosociales sobre la conflictividad en el lugar de trabajo para los profesionales de la salud. Así, la prevención del riesgo psicosocial puede ser una vía eficiente para reducir la conflictividad y para aumentar la satisfacción laboral.
Violence in dating relationships: Validation of the Dominating and Jealous Tactics Scale in Spanish youth
Authors: Muñoz-Rivas Marina J. , Redondo Natalia , Zamarrón Dolores , González María Pilar
Published: January 2019

The Dominant and Jealous Tactics Scale (Kasian & Painter, 1992) is one of the most extensively used instruments to measure dominance and jealousy in dating relationships of young adults and adolescents. The goal of this study is to analyze the psychometric properties of this scale and validate its adequacy for young Spanish population. the sample was made up of 8105 youths from the Region of Madrid, aged between 14 and 26 years. Results of the confirmatory factor analysis indicate two correlated factors: Dominant Tactics and Jealous Tactics, along the lines of the original study. The reliability of the scale was good. With regard to convergent validity, positive and significant correlations were observed with the modified version of the Conflicts Tactics Scale (M-CTS; Neidig, 1986), which measures physical and verbal violence in dating relationships. With regard to known groups validity, we observed significant differences in dominant and jealous tactics as a function of age and gender, in the expected direction. This scale is a reliable and valid instrument to assess dominant and jealous tactics in dating relationships of youth and adolescents in Spain.
Participación familiar en los centros de educación secundaria
Authors: Hernández-Prados María-Ángeles , García-Sanz Maria-Paz , Parra-Martínez Joaquín , Gomariz Vicente María-Ángeles
Published: January 2019

Se analiza la percepción de las familias españolas sobre su participación en los centros escolares de secundaria, identificando perfiles de participación familiar basados en los rasgos sociodemográficos (titularidad del centro, nacionalidad, etc.) y las distintas vías de participación (comunicación, actividades del centro, sentimiento de pertenencia, implicación en AMPA, Consejo escolar y desde el hogar). Se realiza análisis cluster en dos fases con los datos recogidos de 5022 familias de estudiantes de secundaria de España, mediante la aplicación de un cuestionario. Se aprecian tres modelos diferentes de participación familiar en los centros escolares: familias españolas con moderada participación y bajo sentimiento de pertenencia; familias inmigrantes con baja participación y moderado sentimiento de pertenencia; y por último, familias españolas con alta participación y elevado sentimiento de pertenencia.
¿Postureo o disfrute de la experiencia gastronómica? Efectos de la reputación y la experiencia en la recomendación de los restaurantes de alto nivel
Authors: Daries Ramón Natalia , Ferrer Rosell Berta , Cristóbal Fransi Eduard , Mariné Roig Estela
Published: January 2019

En este estudio se ha desarrollado un modelo explicativo basado en la teoría de la moti¬vación fundamentada por la posibilidad de obtener reputación y reconocimiento por con¬sumir gastronomía de alto nivel y la motivación basada en el disfrute de la experiencia gastronómica, con la finalidad de analizar sus efectos en la intención de recomendación de este tipo de experiencias. El estudio confirma que la experiencia gastronómica y el estatus afectan positivamente a la intención de revisita y a la recomendación del consumo de gastro¬nomía de alto nivel, siendo el efecto de la experiencia mucho más fuerte.
Are users’ ratings on Tripadvisor similar to hotel categories in Europe?
Authors: Martin-Fuentes Eva , Mateu Carles , Fernández César
Published: January 2019

European countries do not have the same hotel classification system. Therefore, the criteria and requirements used to assign star ratings to hotels do not concur among the different countries. There have been some criticisms about the way hotel stars are assigned, because the requirements do not necessarily match the quality of service offered. Technical criteria such as infrastructure and room dimensions are taken into account, but users do not perceive them although these have nothing to do with the satisfaction. This study aims to determine whether the hotel category of about 80,000 hotels in 9 different European countries on TripAdvisor is related to customer satisfaction, measured from the point of view of the user ratings on this site. The one-way ANOVA test shows that there are significant differences between the average ratings of the hotel category, except in the classification of 1-star and 2-star hotels from most countries analysed that behave similarly, and 1-star and 3-star hotels from Austria, Greece, Portugal, Spain and UK that are ranked similarly.
Determinación del papel de las características demográficas de los consumidores en el proceso de formación de lealtad basada en aspectos socialmente responsables
Authors: Martínez Patricia , Rodríguez del Bosque Ignacio
Published: January 2019

La responsabilidad social corporativa (RSC) se ha convertido en un elemento crucial en la estrategia corporativa de las compañías hoteleras. Una de las principales razones es que el desarrollo de este tipo de iniciativas favorece el desarrollo de mayores niveles de lealtad entre los consumidores. Igualmente, las características demográficas de los consumidores son una línea de investigación que tradicionalmente ha centrado la atención de multitud de investigadores por considerarse herramientas útiles para la segmentación de los mercados y la caracterización de los consumidores. Sin embargo, son pocos los estudios que han tratado de explorar el papel que juegan las características demográficas de los consumidores en sus respuestas comportamentales basadas en aspectos de RSC. De este modo, el objetivo de esta investigación es analizar el papel de tres características demográficas –género, edad y nivel educativo– en un modelo conceptual que relaciona las percepciones de RSC y la lealtad de los consumidores. Los resultados revelan que estas variables demográficas moderan diversas relaciones del modelo propuesto.
Propuesta metodológica basada en indicadores para la valoración del potencial turístico del paisaje en áreas rurales: el caso del municipio de Atlautla (México)
Authors: Méndez-Méndez Alberto , Serrano de la Cruz Santos-Olmo Manuel Antonio , Salinas Chávez Eduardo , García-Romero Arturo
Published: January 2019

La consideración del paisaje como una herramienta para la planificación del desarrollo turístico es cada vez más común en las zonas rurales de todo el mundo. En este artículo se describe un nuevo método para evaluar el potencial turístico del paisaje en las zonas rurales que aún no se han incorporado al turismo, pero donde se conoce la existencia de un amplio capital natural y cultural. El método se basa en el diseño y uso de indicadores para evaluar la calidad de dos recursos complementarios del potencial turístico: los tipos de paisaje y los atractivos turísticos. La aplicación del método en un municipio del centro de México permi¬tió determinar el potencial turístico de los tipos de paisaje a partir de su calidad intrínseca, más la consideración de la calidad de los atractivos turísticos que albergan en su interior. Los resultados destacan la importancia de la relación paisaje-turismo, considerada en varias esca¬las de análisis, como base para la planificación y gestión de proyectos de turismo sostenible.
Percepciones y valoraciones sociales del paisaje en destinos turísticos. Análisis de la ciudad de Sevilla a través de técnicas de investigación cualitativas
Authors: Mercado Alonso Inmaculada , Fernández Tabales Alfonso
Published: January 2019

El trabajo desarrollado en este artículo tiene como punto de partida el Convenio Europeo de Paisaje (Florencia, 2000) y el protagonismo que en él se otorga a la percepción social en su propia definición. Entendiendo que la población que percibe se compone, en el caso de los espacios turísticos, tanto de residentes como de visitantes, se plantea obtener información sobre cómo se percibe el paisaje urbano en los espacios de mayor frecuentación turística de la ciudad de Sevilla, cuáles son los principales conflictos identificados y las aspiraciones proyectadas en ambos grupos mediante la aplicación de una metodología de análisis cualitativo. A partir de dicha información se apuntan algunas conclusiones que pueden ser de utilidad en la gestión del paisaje urbano en espacios turísticos.
Aportación a los conceptos de turismo marinero/pesquero y pesca-turismo.
Authors: Moreno Muñoz Daniel
Published: January 2019

En los últimos años, los lugares costeros con una fuerte tradición pesquera intentan fomentar una nueva modalidad turística, el denominado turismo marinero/pesquero. Sin embargo, aún no se ha definido de forma unánime el concepto, ya que las distintas Leyes de Pesca presentan para esta actividad una diversidad de meanings. En esta investigación se muestran los resultados del análisis de la legislación existente en esta materia, así como de la literatura científica, y se aporta una nueva definición de turismo/pesquero y de pesca-turismo, con el fin de aclarar ambos términos.
Turismo de cruceros en la interfaz puerto-ciudad Mediterránea: nueva época del waterfront, con beneficios en un Smart Destination
Authors: Perea-Medina Beatriz , Andrade María J. , Rosa-Jiménez Carlos
Published: January 2019

Este estudio se sitúa en la literatura sobre la industria de cruceros atendiendo al fenó¬meno waterfront y al desarrollo de una nueva interfaz crucero-ciudad promovida por el turismo de cruceros. Se parte de una hipótesis, el desarrollo de una nueva época del water¬front con la implicación del turismo de cruceros, que incide tanto en el waterfront como en el puerto, bajo el desarrollo de una nueva imagen como puerta de entrada a la ciudad, y la ciudad mediterránea, principalmente su casco histórico, al ser el área cultural atrayente, que forman parte de las intervenciones en la búsqueda de la relación puerto-ciudad. En este sen¬tido, se ponen de manifiesto los impactos positivos y negativos que trae consigo este tipo de turismo, tras estudiar diferentes casos de ciudades portuarias mediterráneas y se concluye, con la propuesta de una integración a través del desarrollo de un Smart Cruise Port en un Smart Destination, que beneficiaría la interrelación crucero-ciudad.
INVESTIGATION OF THE HUMAN RESOURCES NEEDS FOR THE EFFECTIVE AND EFFICIENT IMPLEMENTATION OF THE SHEEP AND GOAT BRUCELLOSIS PROGRAM IN GREECE
Authors: KATSIOLIS Aristomenis , THANOU Olga , TZANI Myrsini , DILE Chrysoula , KOROU Marilina , STOURNARA Athanasia , PETRIDOU Evanthia , GIADINIS Nektarios
Published: January 2019

The sheep and goats brucellosis program is one of the most important animalhealth programs with significant animal health, public health, and internationaltrade consequences. Several factors are involved in the implementation of thisprogram, while its success depends on the availability of an effective, well-trained,and fully engaged staff. Considering the poor results of sheep and goats brucellosisprogram in Greece mainly related to the limited number of veterinarians workingin the regional veterinary services, the present study aims to approach the numberof the human resources and more precisely of veterinarians that are essential forthe effective and efficient brucellosis control strategy in Greece. Therefore, the dataderived by the performance of the program for the years 2012 to 2015 are analyzed.Finally, economic and political circumstances – external factors that affect thefunctionality of the program as well as all relevant bottlenecks are being discussed.The findings of the present study indicate that approximately 485 veterinarians with485 assistants working for the needs of the brucellosis program would significantlyassist on the complete implementation of the brucellosis control and eradication ofthe disease in Greek sheep and goat holdings.
TRICHOPHYTOSIS IN BEEF CATTLE
Authors: DAVIDOV Ivana , RADINOVIĆ Miodrag , KOVAČEVIĆ Zorana , ERDELJAN Mihajlo , GALFI Annamaria , ILIĆ Saša
Published: January 2019

Trichophytosis is one of the most common skin diseases in cattle.Trichophytosis is a transmissible infectious skin disease caused most often byTrichophyton verrucosum with spores which can remain alive for years in a dryenvironment. This is a zoonotic disease, as it can equally infect people and animals.The infection spreads rapidly, and this fungal disease leads to certain economiclosses. Direct contact with infected animals is the most common method of spreadingthe infection. During this research, beef cattle aged 4 months were transported fromsouthern Serbia to the part of Vojvodina - Mačva. One month after the transportation,the characteristic gray-white round changes occured on the skin of beef cattle.Affected animals from five individual farms did not receive any treatment, whileanimals from other five farms were treated with Decanol® solution. As a conclusion,application of therapy or vaccination along with a high quality diet is the best wayto to suppress triphophytosis.
A fast iris recognition system through optimum feature extraction
Authors: Rana Humayan Kabir , Azam Md. Shafiul , Akhtar Mst. Rashida , Quinn Julian M.W. , Moni Mohammad Ali
Published: January 2019

With an increasing demand for stringent security systems, automated identification of individuals based on biometric methods has been a major focus of research and development over the last decade. Biometric recognition analyses unique physiological traits or behavioral characteristics, such as an iris, face, retina, voice, fingerprint, hand geometry, keystrokes or gait. The iris has a complex and unique structure that remains stable over a person's lifetime, features that have led to its increasing interest in its use for biometric recognition.

In this study, we proposed a technique incorporating Principal Component Analysis (PCA) based on Discrete Wavelet Transformation (DWT) for the extraction of the optimum features of an iris and reducing the runtime needed for iris templates classification. The idea of using DWT behind PCA is to reduce the resolution of the iris template. DWT converts an iris image into four frequency sub-bands. One frequency sub-band instead of four has been used for further feature extraction by using PCA. Our experimental evaluation demonstrates the efficient performance of the proposed technique.
Cetacean morbillivirus, a journey from land to sea and vice versa
Authors: Di Guardo Giovanni , Mazzariol Sandro
Published: January 2019

Cetacean Morbillivirus, the most relevant pathogen impacting the health and conservation of cetaceans worldwide, has shown in recent years an increased tendency to cross “interspecies barriers”, thereby giving rise to disease and mortality outbreaks in free-ranging dolphins and whales. The present “Opinion Article” deals with the evolutionary “trajectories” of this viral pathogen, likely originating from Rinderpest Virus, along with its "journey" from land to sea (and vice versa), mimicking that of cetaceans' terrestrial ancestors.
Rapid changes in tissue mechanics regulate cell behaviour in the developing embryonic brain
Authors: Thompson Amelia J , Pillai Eva K , Dimov Ivan B , Foster Sarah K , Holt Christine E , Franze Kristian
Published: January 2019

Tissue mechanics is important for development; however, the spatio-temporal dynamics of in vivo tissue stiffness is still poorly understood. We here developed tiv-AFM, combining time-lapse in vivo atomic force microscopy with upright fluorescence imaging of embryonic tissue, to show that during development local tissue stiffness changes significantly within tens of minutes. Within this time frame, a stiffness gradient arose in the developing Xenopus brain, and retinal ganglion cell axons turned to follow this gradient. Changes in local tissue stiffness were largely governed by cell proliferation, as perturbation of mitosis diminished both the stiffness gradient and the caudal turn of axons found in control brains. Hence, we identified a close relationship between the dynamics of tissue mechanics and developmental processes, underpinning the importance of time-resolved stiffness measurements.
Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing
Authors: Yang Fu , Quan Zhenghui , Huang Huanwei , He Minghui , Liu Xicheng , Cai Tao , Xi Rongwen
Published: January 2019

Heterochromatin Protein 1 (HP1) is a conserved chromosomal protein in eukaryotic cells that has a major role in directing heterochromatin formation, a process that requires co-transcriptional gene silencing mediated by small RNAs and their associated argonaute proteins. Heterochromatin formation requires erasing the active epigenetic mark, such as H3K4me2, but the molecular link between HP1 and H3K4 demethylation remains unclear. In a fertility screen in female Drosophila, we identified ovaries absent (ova), which functions in the stem cell niche, downstream of Piwi, to support germline stem cell differentiation. Moreover, ova acts as a suppressor of position effect variegation, and is required for silencing telomeric transposons in the germline. Biochemically, Ova acts to link the H3K4 demethylase dLsd1 to HP1a for local histone modifications. Therefore, our study provides a molecular connection between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development, transposon silencing, and heterochromatin formation.

Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (see decision letter).
Programmed genome editing of the omega-1 ribonuclease of the blood fluke, Schistosoma mansoni
Authors: Ittiprasert Wannaporn , Mann Victoria H , Karinshak Shannon E , Coghlan Avril , Rinaldi Gabriel , Sankaranarayanan Geetha , Chaidee Apisit , Tanno Toshihiko , Kumkhaek Chutima , Prangtaworn Pannathee , Mentink-Kane Margaret M , Cochran Christina J , Driguez Patrick , Holroyd Nancy , Tracey Alan , Rodpai Rutchanee , Everts Bart , Hokke Cornelis H , Hoffmann Karl F , Berriman Matthew , Brindley Paul J
Published: January 2019

CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle. This secreted ribonuclease is crucial for Th2 polarization and granuloma formation. Schistosome eggs were exposed to Cas9 complexed with guide RNA complementary to ω1 by electroporation or by transduction with lentiviral particles. Some eggs were also transfected with a single stranded donor template. Sequences of amplicons from gene-edited parasites exhibited Cas9-catalyzed mutations including homology directed repaired alleles, and other analyses revealed depletion of ω1 transcripts and the ribonuclease. Gene-edited eggs failed to polarize Th2 cytokine responses in macrophage/T-cell co-cultures, while the volume of pulmonary granulomas surrounding ω1-mutated eggs following tail-vein injection into mice was vastly reduced. Knock-out of ω1 and the diminished levels of these cytokines following exposure showcase the novel application of programmed gene editing for functional genomics in schistosomes.
Programmed knockout mutation of liver fluke granulin attenuates virulence of infection-induced hepatobiliary morbidity
Authors: Arunsan Patpicha , Ittiprasert Wannaporn , Smout Michael J , Cochran Christina J , Mann Victoria H , Chaiyadet Sujittra , Karinshak Shannon E , Sripa Banchob , Young Neil David , Sotillo Javier , Loukas Alex , Brindley Paul J , Laha Thewarach
Published: January 2019

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor (IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2012) for cholangiocarcinoma (CCA) in the Lower Mekong River Basin countries including Thailand, Lao PDR, Vietnam and Cambodia. We exploited this link to explore the role of the secreted growth factor termed liver fluke granulin (Ov-GRN-1) in pre-malignant lesions by undertaking programmed CRISPR/Cas9 knockout of the Ov-GRN-1 gene from the liver fluke genome. Deep sequencing of amplicon libraries from genomic DNA of gene-edited parasites revealed Cas9-catalyzed mutations within Ov-GRN-1. Gene editing resulted in rapid depletion of Ov-GRN-1 transcripts and the encoded Ov-GRN-1 protein. Gene-edited parasites colonized the biliary tract of hamsters and developed into adult flukes, but the infection resulted in reduced pathology as evidenced by attenuated biliary hyperplasia and fibrosis. Not only does this report pioneer programmed gene-editing in parasitic flatworms, but also the striking, clinically-relevant pathophysiological phenotype confirms the role for Ov-GRN-1 in virulence morbidity during opisthorchiasis.
Quantitative proteomics reveals key roles for post-transcriptional gene regulation in the molecular pathology of facioscapulohumeral muscular dystrophy
Authors: Jagannathan Sujatha , Ogata Yuko , Gafken Philip R , Tapscott Stephen J , Bradley Robert K
Published: January 2019

DUX4 is a transcription factor whose misexpression in skeletal muscle causes facioscapulohumeral muscular dystrophy (FSHD). DUX4’s transcriptional activity has been extensively characterized, but the DUX4-induced proteome remains undescribed. Here, we report concurrent measurement of RNA and protein levels in DUX4-expressing cells via RNA-seq and quantitative mass spectrometry. DUX4 transcriptional targets were robustly translated, confirming the likely clinical relevance of proposed FSHD biomarkers. However, a multitude of mRNAs and proteins exhibited discordant expression changes upon DUX4 expression. Our dataset revealed unexpected proteomic, but not transcriptomic, dysregulation of diverse molecular pathways, including Golgi apparatus fragmentation, as well as extensive post-transcriptional buffering of stress-response genes. Key components of RNA degradation machineries, including UPF1, UPF3B, and XRN1, exhibited suppressed protein, but not mRNA, levels, explaining the build-up of aberrant RNAs that characterizes DUX4-expressing cells. Our results provide a resource for the FSHD community and illustrate the importance of post-transcriptional processes in DUX4-induced pathology.
SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension
Authors: Gao Kaiyu , Li Yi , Hu Shumei , Liu Ying
Published: January 2019

Animals respond to mitochondrial stress with the induction of mitochondrial unfolded protein response (UPRmt). A cascade of events occur upon UPRmt activation, ultimately triggering a transcriptional response governed by two transcription factors: DVE-1 and ATFS-1. Here we identify SUMO-specific peptidase ULP-4 as a positive regulator of C. elegans UPRmt to control SUMOylation status of DVE-1 and ATFS-1. SUMOylation affects these two axes in the transcriptional program of UPRmt with distinct mechanisms: change of DVE-1 subcellular localization vs. change of ATFS-1 stability and activity. Our findings reveal a post-translational modification that promotes immune response and lifespan extension during mitochondrial stress.
Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity
Authors: Zhang Feng , Swartz Kenton Jon , Jara-Oseguera Andres
Published: January 2019

The Transient Receptor Potential Vanilloid 1 (TRPV) channel is activated by an array of stimuli, including heat and vanilloid compounds. The TRPV1 homologues TRPV2 and TRPV3 are also activated by heat, but sensitivity to vanilloids and many other agonists is not conserved among TRPV subfamily members. It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx). Here, we show that mutation of six residues in TRPV3 corresponding to the vanilloid site in TRPV1 is sufficient to engineer RTx binding. However, robust activation of TRPV3 by RTx requires facilitation of channel opening by introducing mutations in the pore, temperatures > 30°C, or sensitization with another agonist. Our results demonstrate that the energetics of channel activation can determine the apparent sensitivity to a stimulus and suggest that allosteric pathways for activation are conserved in the TRPV family.
Assessing Competency in Family Medicine Residents Using the Osteopathic Manipulative Medicine Mini-Clinical Evaluation Exercise
Authors: LeBeau Lawrence , Morgan Christine , Heath Deborah , Pazdernik Vanessa K.
Published: January 2019

Context

The Mini-Clinical Evaluation Exercise (Mini-CEX) is one example of a direct observation tool used for workplace-based skills assessment. The Mini-CEX has been validated as a useful formative evaluation tool in graduate medical education. However, no Mini-CEX has been reported in the literature that specifically assesses the osteopathic manipulative medicine (OMM) skills of family medicine residents. Therefore, the authors created and studied an OMM Mini-CEX to fill this skills assessment gap.

Objective

To determine whether the OMM Mini-CEX is perceived as an effective evaluation tool for assessing the OMM core competencies of family medicine residents.

Methods

Faculty and residents of The Wright Center for Graduate Medical Education National Family Medicine Residency program participated in the study. Each resident was evaluated at least once using the OMM Mini-CEX. Surveys were used to assess faculty and resident perceptions of the usefulness and effectiveness of the OMM Mini-CEX for assessing OMM competencies.

Results

Eighty-one responses were received during 2 survey cycles within a 7-month period. The internal consistency of the survey responses had a high reliability (Cronbach α=0.93). Considering respondents who agreed that they had a clear understanding of the general purpose of a Mini-CEX, the perceived effectiveness score for the OMM Mini-CEX was higher among those who agreed that a Mini-CEX was a useful part of training than among those who disagreed or were unsure of its usefulness (median score, 4.0 vs 3.4, respectively; P=.047).

Conclusions

The results suggest the OMM Mini-CEX can be a useful direct observation evaluation tool to assess OMM core competencies in family medicine residents. Additional research is needed to determine its perceived effectiveness in other clinical specialties and in undergraduate medical education.
SMOKE AND HEAT DETECTORS ARRANGEMENT IN HALLWAYS
Authors: Jevtić Radoje , Blagojević Milan
Published: January 2019

Fire protection systems present very complex real time
systems that comprehend many different parts. Fire detectors present one of those parts. Fire detectors could be divided on several different ways depended on criteria. Very frequently used detectors in many fire protection systems were heat and smoke detectors. Their main role is to detect fire at early stage. Their number and arrangement in object is strictly regulated by proper standards. For some cases, there were certain differences between standards. This paper has written to show the potential arrangement of smoke and heat detectors in object with hallways realized by simulation in PyroSim 2012 simulator.
Key words: detector, arrangement, simulation
Common garden comparisons confirm inherited differences in sensitivity to climate change between forest tree species
Authors: Sáenz-Romero Cuauhtémoc , Kremer Antoine , Nagy László , Újvári-Jármay Éva , Ducousso Alexis , Kóczán-Horváth Anikó , Hansen Jon Kehlet , Mátyás Csaba
Published: January 2019

The natural distribution, habitat, growth and evolutionary history of tree species are strongly dependent on ecological and genetic processes in ecosystems subject to fluctuating climatic conditions, but there have been few experimental comparisons of sensitivity between species. We compared the responses of two broadleaved tree species (Fagus sylvaticaandQuercus petraea) and two conifer tree species (Pinus sylvestrisandPicea abies) to climatic transfers by fitting models containing the same climatic variables. We used published data from European provenance test networks to model the responses of individual populations nested within species. A mixed model approach was applied to develop a response function for tree height over climatic transfer distance, taking into account the climatic conditions at both the seed source and the test location. The two broadleaved species had flat climatic response curves, indicating high levels of plasticity in populations, facilitating adaptation to a broader range of environments, and conferring a high potential for resilience in the face of climatic change. By contrast, the two conifer species had response curves with more pronounced slopes, indicating a lower resilience to climate change. This finding may reflect stronger genetic clines inP. sylvestrisandP. abies,which constrain their climate responses to narrower climatic ranges. The response functions had maxima that deviated from the expected maximum productivity in the climate of provenance towards cooler/moister climate conditions, which we interpreted as an adaptation lag. Unilateral, linear regression analyses following transfer to warmer and drier sites confirmed a decline in productivity, predictive of the likely impact of ongoing climate change on forest populations. The responses to mimicked climate change evaluated here are of considerable interest for forestry and ecology, supporting projections of expected performance based on “real-time” field data.
Serverless OpenHealth at data commons scale—traversing the 20 million patient records of New York’s SPARCS dataset in real-time
Authors: Almeida Jonas S. , Hajagos Janos , Saltz Joel , Saltz Mary
Published: January 2019

In a previous report, we explored the serverless OpenHealth approach to the Web as a Global Compute space. That approach relies on the modern browser full stack, and, in particular, its configuration for application assembly by code injection. The opportunity, and need, to expand this approach has since increased markedly, reflecting a wider adoption of Open Data policies by Public Health Agencies. Here, we describe how the serverless scaling challenge can be achieved by the isomorphic mapping between the remote data layer API and a local (client-side, in-browser) operator. This solution is validated with an accompanying interactive web application (bit.ly/loadsparcs) capable of real-time traversal of New York’s 20 million patient records of the Statewide Planning and Research Cooperative System (SPARCS), and is compared with alternative approaches. The results obtained strengthen the argument that the FAIR reproducibility needed for Population Science applications in the age of P4 Medicine is particularly well served by the Web platform.
Assessing Teacher Digital Competence: the Construction of an Instrument for Measuring the Knowledge of Pre-Service Teachers
Authors: Lázaro Cantabrana José Luis , Usart Rodríguez Mireia , Gisbert Cervera Mercè
Published: January 2019

Assessing competences always poses a challenge and can be even more complicated when tackling a multidimensional competence like teacher digital competence (TDC). TDC is understood to consist of different dimensions linked to its components. This complexity gives rise to the need to organize and systematize both TDC training and its evaluation through a standard based on validated benchmark indicators. Designing and developing an instrument for TDC assessment has been a two-phase process. The COMDID-A self-assessment tool was developed in the first phase and COMDID-C, an instrument for assessing knowledge related to TDC, in the second. In this article we present the process of constructing the COMDID-C instrument. For this first stage, we worked with two samples, an expert validation and a pilot test sample. Due to the complexity of the test, we conducted a preliminary evaluation of the validity of its content, construction and reliability. Our results indicate that the test is well designed and consistent with its intended purpose. The next step will be administering the test to a larger sample that will allow the instrument to be externally validated.
Carcinoma Mucoepidermóide: Revisão de Literatura
Authors: Luís Cristina Mendes , Israel Mônica Simões
Published: January 2019

O objetivo deste estudo é promover uma revisão de literatura sobre o carcinoma mucoepidermóide, um tumor raro de glândula salivar e ressaltar a importância do diagnóstico histopatológico prévio à cirurgia definitiva, mesmo quando há características de benignidade.
Aspectos gerais da Síndrome do X-Frágil: principal causa hereditária de retardo mental
Authors: Gómez Marcela Kelly Astete , Acosta Angelina Xavier
Published: January 2019

Existe uma grande necessidade de divulgar informações sobre a Síndrome do X-frágil (SXF), não só para as famílias, mas principalmente para os profissionais da área de saúde. A SXF é considerada a principal causa hereditária e a segunda etiologia genética de retardo mental (RM). O indivíduo acometido pela SXF apresenta uma mutação no gene FMR-1 (Fragile Mental Retardation 1), localizado no cromossomo X. Além do RM, as principais características são: face alongada, orelhas grandes e macroorquidia. O tratamento atual disponível requer uma abordagem multidisciplinar, podendo combinar atendimentos terapêuticos, educação especial e uso de medicamentos de acordo com as necessidades específicas de cada portador. A SXF vem merecendo grande atenção, não apenas por sua prevalência, mas também pelas peculiaridades de sua transmissão e por distúrbios a ela associados. É de grande importância a identificação das famílias nas quais os alelos estão se segregando na forma de pré-mutação, para melhor orientação no aconselhamento genético.
O pragmatismo na educação médica
Authors: Schanaider Alberto
Published: January 2019

O decreto denominado REUNI tem fomentado intensa discussão e polêmica nas instituições Federais de Ensino Superior (IFES). Nesse cenário, a formação médica encontra-se na berlinda. Várias diretrizes não são adequadas para formar um médico preparado para o seu exercício profissional. Assim, acossados pela realidade da saúde pública, é imprescindível que a universidade e o Estado interajam para superar os desafios do processo ensino-aprendizagem e para zelar pela qualidade dos egressos.
Pode dançar provocar dor no joelho?
Authors: Peña Norberto , Mattar Márcia , Leite Carla , Lima Joana , Teixeira Jamille
Published: January 2019

A dor no joelho é uma das queixas mais freqüentes entre dançarinos. O objetivo deste trabalho foi estabelecer a prevalência e a incidência cumulativa de dor no joelho para melhor entender a relação entre dançar e o corpo do dançarino. Constituíram a amostra 47 alunos da Escola de Dança da UFBA. Para estabelecer a freqüência de dor no joelho foram escolhidos dois desenhos metodológicos: um estudo prospectivo, para estabelecer a prevalência, e um estudo de coorte, para verificar a incidência cumulativa da variável. Como resultado, verificou-se que a prevalência de dor no joelho entre 47 alunos foi de 31.9% (15 alunos). A incidência representada manteve-se entre 13.3% e 2.2%, apresentando uma gradativa tendência à diminuição.
O ganho de força dos direitos dos animais
Authors: FAVRE David
Published: January 2019

O foco deste artigo é traçar o progresso que tem se realizado em benefício dos
animais dentro das instituições jurídicas dos Estados Unidos. Enquanto existe uma
focalização na adoção de novas leis, existem ainda muitos passos ou mudanças que
são necessárias dentro das instituições jurídicas como um todo, se quisermos fazer
um progresso substancial em termos de mudança e implementação das leis. Por
exemplo, ao mesmo tempo em que legisladores devem estar convencidos da necessidade
de mudança, os juízes devem acreditar nas novas leis, caso contrário, a implementação
das leis não acontecerá.
Além dos tribunais e do parlamento, as instituições jurídicas incluem faculdades
de direito, revistas jurídicas, e as várias associações de advogados e de professores de
direito. Qual é a visibilidade e a credibilidade da temática animal nessas instituições?
Se não houver o progresso em todos os setores da comunidade jurídica, o sucesso da
proteção dos animais não será possível. Nós, nos Estados Unidos, temos progredido,
particularmente, nos últimos dez anos, mas ainda há muito por fazer. Ao mapear o
progresso e a sua falta, nos Estados Unidos, os leitores brasileiros e de outros países
terão algumas referências para que possam avaliar o progresso da questão dos direitos
e do bem-estar dos animais dentro de seus próprios países.
Dos Direitos morais aos Direitos Constitucionais - Para além do especismo elitista e eletivo
Authors: FELIPE Sônia T.
Published: January 2019

...
Ação civil pública em face da crueldade praticada pelo Centro de Controle de Zoonozes de Aracaju (Sergipe)
Authors: COSTA Sandro Luiz da
Published: January 2019

...
Algumas notas sobre a dimensão ecológica da dignidade da pessoa humana e sobre a dignidade da vida em geral
Authors: SARLET Ingo Wolfgang , FENSTERSEIFER Tiago
Published: January 2019

O presente estudo, à luz da teoria dos direitos fundamentais e de ordem jurídico-constitucional brasileira, analisa a dimensão ecológica da dignidade humana, bem como o reconhecimento da dignidade inerente a outras formas de vida não-humanas e à vida em geral.
Termo de Ajustamento de Conduta firmado entre MP/BA e Jardim Zoológico de Salvador/BA
Authors: Gordilho Heron Santana
Published: January 2019

Pelo presente instrumento, o MINISTÉRIO PÚBLICO DO
ESTADO DA BAHIA, por intermédio da Primeira e da Segunda
Promotorias de Justiça do Meio Ambiente de Salvador, doravante
denominadas MINISTÉRIO PÚBLICO, e a SECRETARIA DE MEIO
AMBIENTE E RECURSOS HIDRICOS - SEMARH, localizado no
Centro Administrativo da Bahia, 3ª Avenida, nº 390, 4º Andar, por
seu Secretário da pasta, doravante denominado COMPROMISSÁRIO.
Parecer: utilização de animais em rodeios
Authors: MARTINS Renata De Freitas
Published: January 2019

A pedido da Mountarat Associação de Proteção Ambiental
elaboramos parecer sobre a utilização de animais em rodeios
como embasamento contrário ao Projeto de Lei, de autoria
do Sr. Veredor Alemão do Cruzado, que dispõe sobre a
promoção e realização de rodeio no Município de Santo André
e dá outras providências, com a consequente revogação da Lei
e do artigo  da Lei tendo em vista que se trata
de pretensão flagrantemente inconstitucional e ilegal, e no caso
de sua eventual aprovação, faria com que o Município deixasse
de cumprir fielmente a legislação ambiental pátria, não se coadunando com a tão necessária evolução sócio-ambiental.
AS (DES)ANALOGIAS ENTRE RACISMO E ESPECISMO
Authors: NACONECY Carlos M.
Published: January 2019

O ensaio trata de uma das mais importantes peças
argumentativas na defesa do status moral dos animais não-humanos,
a saber, aquela que evoca a semelhança moral entre duas formas de
discriminação preconceituosa - racismo e especismo. A análise inicia
caracterizando o que é um argumentum per analogiam e seu papel na
Ética Animal. Deixando de lado os pontos mais conhecidos dessa
aproximação analógica, na segunda parte, o estudo focaliza os aspectos
compartilhados mais sutis e, na terceira, o que há de moralmente
desanálogo entre atitudes racistas e especistas. O objetivo é mostrar
que seria enganador inferir que há uma simetria rigorosa entre ambos
os preconceitos, ao contrário do que é usualmente sustentado por
muitos eticistas.
PARADIGMAS FILOSÓFICOS - AMBIENTAIS E O DIREITO DOS ANIMAIS
Authors: CHALFUN Mary
Published: January 2019

No presente artigo, abordam-se alguns paradigmas
filosóficos e ambientais tais como antropocentrismo utilitarista
alargado, o ecocentrismo e ecologia profunda, juntamente com o
direito dos Animais. Pensamentos estes que influenciam de um lado
para o tratamento de subjugação animal e da natureza, de superioridade
humana, e de outro para um tratamento de equilíbrio, mais
igualitário. Aponta-se para o pensamento de que o Direito dos
Animais é uma realidade, que ultrapassa o entendimento de mero
ramo do direito ambiental, tratando-se de verdadeiro ramo autônomo,
multidisciplinar, uma realidade necessária, primordial para todos.
Essencial para que haja harmonia e respeito entre todas as espécies.
L'INESCUSABILE SPECISMO DEL MANGIATORE DI TARTARE DIVAGAZIONI SUI DIRITTI DEGLI ANIMALI
Authors: CHIASSONI Pierluigi
Published: January 2019

O Professor Pierluigi Chiassoni escreveu sobre os direitos dos

animais a um livro dedicado ao prof Silvana Castignone que estava
entre os primeiros a introduzir a questão dos direitos dos animais na
cultura jurídica italiana
O ABOLICIONISMO ANIMAL E A PARTICIPAÇÃO DO PODER PÚBLICO ATRAVES DA TRIBUTAÇÃO PASSIVA
Authors: MAZZOCHI Fernanda , PEREZ Pablo Luiz Barros
Published: January 2019

O Direito dos Animais é contextualizado como instrumento
essencial na transição dos animais da condição de objetos para o
status moral de sujeitos de direitos. São abordadas as constituições
do Brasil, da Alemanha e da Espanha em relação à questão ambiental
e dos animais. Após é explanada a Tributação como política pública
fomentadora da proteção dos animais O viés extra fiscal da tributação
é apresentado como veículo de indução da sociedade em prol dos
direitos dos animais Ao final são apresentados alguns projetos de lei
em tramitação ou arquivados que apresentem propostas de incentivos
tributários aos contribuintes que agirem na proteção dos animais, bem
como apresenta ideias possíveis para futuras propostas legislativas.
ABOLICIONISMO E DIREITO ANIMAL - DESCONSTRUINDO PARADIGMAS: UMA ABORDAGEM SOB O PRISMA DOS MOVIMENTOS EM PROL DOS DIREITOS ANIMAIS E DA ÉTICA DO CUIDADO
Authors: GRANT Carolina
Published: January 2019

O presente estudo te por escopo traçar um breve panorama acerca do abolicionismo e direito animal, mediante a compreensão e delineamento da ideologia/paradigma especista; o estudo, ainda que breve, dos principais movimentos em prol dos interesses e direitos animais, tais como Libertação Animal (Peter Singer) e Abolicionismo Animal (Tom Regan); a discussão em torno das cetegorias "sujeitos de direitos" e "personalidade jurídica" relativamente à tutela jurídica dos direitos animais; e a identificação dos contributos da ética do cuidado para a conformação de um novo paradigma moral/ideológico/filosófico capaz de atender às novas demandas sociais, globais, humanísticas e animais. A abordagem se dará através da proposta de desconstrução paradigmática, reflexão filosófica, revisão de pré-compreensões e conclusões gradualmente propositivas, de ordem sobretudo ideológica, filosófica e moral, mas também, evidentemente, jurídica.