bluuebunny/crossref_metadata_2025 huggingface dataset:
STUDY ON CHEMICAL CONSTITUENTS AND CYTOTOXICITY OF ASPIDISTRA LETREAE
Authors: Ho Duc Viet
Published: March 2020

A phytochemical investigation of whole Aspidistra letreae plants led to the isolation of 2H-chromen-2-one (1), α-tocopherol (2), (E)-phytol (3), asparenydiol (4) and (25S)-spirost-1β,3α,5β-triol (5). Their structures were determined on the basis of NMR spectral evidences and in comparison with the reported data. Of these, asparenydiol (4) was isolated from the genus Aspidistra for the first time. This is also the first report on the separation and structural determination of (25S)-spirost-1β,3α,5β-triol (5) as a pure compound. The methanol extract exhibited a moderate cytotoxicity against the LU-1, HeLa, MDA-MB-231, Hep-G2, and MKN-7 human cancer cell lines with IC50 values ranging from 52.58 ± 3.65 to 64.78 ± 4.89 μg/mL.
A theoretical study of structure, bonding and property of platinum(II)-8-hydroxyquinolines complexes with carbene and heavier homologues
Authors: Loan Huynh Thi Phuong , Duc Hoang Van , Nhung Nguyen Thi Ai
Published: March 2020

In this work, a theoretical study for platinum(II)-8-hydroxyquinolines-tetrylene complexes [{PtCl-C9H6NO}-NHEPh] (Pt-EPh) are investigated for the first time using density functional theory (DFT). Quantum chemical calculations using DFT and charge methods at the BP86 level with basic sets SVP, TZVPP have been carried out to get insight into the structures and property for Pt-EPh. The optimization of equilibrium geometries of the ligands EPh in Pt-EPh are bonded in distorted end-on way to Pt fragment with the bending angle, a, slightly decreases from carbene Pt-CPh to germylene Pt-GePh. Quantum chemical parameters such as EHOMO, ELUMO, the energy gap (ELUMO – EHOMO), electronegativity (χ), global hardness (η), and global softness (S) in the neutral molecules have been calculated and discussed. Bond dissociation energies (BDEs), De (kcal.mol-1), decrease from the slighter to the heavier homologues. The hybridization of atoms E have large p characters while the hybridization of atom Pt has greater d character which lead to the Pt-E bond possesses not only NHEPh→{ PtCl-C9H6NO} strong σ-donation but also a significant contribution π-donation NHEPh→{PtCl-C9H6NO} and a weak π-backdonation metal-ligand NHEPh←{PtCl-C9H6NO} in complexes Pt-Eph was also considered.
Completeness of tuberculosis (TB) notification: inventory studies and capture-recapture analyses, six European Union countries, 2014 to 2016
Authors: Straetemans Masja , Bakker Mirjam I , Alba Sandra , Mergenthaler Christina , Rood Ente , Andersen Peter H , Schimmel Henrieke , Simunovic Aleksandar , Svetina Petra , Carvalho Carlos , Lyytikäinen Outi , Abubakar Ibrahim , Harris Ross J , Ködmön Csaba , van der Werf Marieke J , van Hest Rob
Published: March 2020

Background

Progress towards the World Health Organization’s End TB Strategy is monitored by assessing tuberculosis (TB) incidence, often derived from TB notification, assuming complete case detection and reporting. This assumption is unlikely to hold in many settings, including European Union (EU) countries.

Aim

We aimed to assess observed and estimated completeness of TB notification through inventory studies and capture–recapture (CRC) methodology in six EU countries: Croatia, Denmark, Finland, the Netherlands, Portugal Slovenia.

Methods

We performed record linkage, case ascertainment and CRC analyses of data collected retrospectively from at least three national TB-related registers in each country between 2014 and 2016.

Results

Observed completeness of TB notification by inventory studies was 73.9% in Croatia, 98.7% in Denmark, 83.6% in Finland, 81.6% in the Netherlands, 85.8% in Portugal and 100% in Slovenia. Subsequent CRC analysis estimated completeness of TB notification to be 98.4% in Denmark, 76.5% in Finland and 77.0% in Portugal. In Croatia, CRC analyses produced implausible results while in the Netherlands and Slovenia, it was methodologically considered not meaningful.

Conclusion

Inventory studies and CRC methodology suggest a TB notification completeness between 73.9% and 100% in the six EU countries. Mandatory reporting by clinicians and laboratories, and cross-checking of registers, strongly contributes to accurate notification rates, but hospital episode registers likely contain a considerable proportion of false-positive TB records and are thus less useful. Further strengthening routine surveillance to count TB cases, i.e. incidence, accurately by employing record-linkage of high-quality TB registers should make CRC studies obsolete in EU countries.
Coronavirus disease (COVID-19) Community Testing Team in Scotland: A 14-day review, 6 to 20 February 2020
Authors: Mark Kate , Steel Katie , Stevenson Janet , Evans Christine , McCormick Duncan , Willocks Lorna , McCallum Alison , Jones Laura , Johannessen Ingolfur , Templeton Kate , Koch Oliver , Mackintosh Claire
Published: March 2020

In response to the outbreak of COVID-19, we set up a team to carry out sampling in the community. This enabled individuals to remain in self-isolation in their own homes and to prevent healthcare settings and services from being overwhelmed by admissions for sampling of suspected cases. There is evidence that this is a cost effective, safe and necessary service to complement COVID-19 testing in hospitals.
Candida auris: epidemiological situation, laboratory capacity and preparedness in the European Union and European Economic Area*, January 2018 to May 2019
Authors: Plachouras Diamantis , Lötsch Felix , Kohlenberg Anke , Monnet Dominique L ,   the Candida auris survey collaborative group
Published: March 2020

Between January 2018 and May 2019, 349 cases of Candida auris were reported in the European Union/European Economic Area*, 257 (73.6%) colonisations, 84 (24.1%) bloodstream infections, seven (2.0%) other infections and one case of unknown infection/colonisation status (0.3%). Most cases (97.1%, n = 339) were reported from Spain or the United Kingdom, but also for the first time in Greece, the Netherlands and Poland. Laboratory capacity and preparedness has improved since January 2018.
Rapid assessment of regional SARS-CoV-2 community transmission through a convenience sample of healthcare workers, the Netherlands, March 2020
Authors: Reusken Chantal B , Buiting Anton , Bleeker-Rovers Chantal , Diederen Bram , Hooiveld Mariëtte , Friesema Ingrid , Koopmans Marion , Kortbeek Titia , Lutgens Suzanne PM , Meijer Adam , Murk Jean-Luc , Overdevest Ilse , Trienekens Thera , Timen Aura , Van den Bijllaardt Wouter , Van Dissel Jaap , Van Gageldonk-Lafeber Arianne , Van der Vegt Dewi , Wever Peter C , Van der Hoek Wim , Kluytmans Jan
Published: March 2020

To rapidly assess possible community transmission in Noord-Brabant, the Netherlands, healthcare workers (HCW) with mild respiratory complaints and without epidemiological link (contact with confirmed case or visited areas with active circulation) were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Within 2 days, 1,097 HCW in nine hospitals were tested; 45 (4.1%) were positive. Of six hospitals with positive HCW, two accounted for 38 positive HCW. The results informed local and national risk management.
НЕСПОРТИВНИЙ ЖЕСТ КОЗАКЕВИЧА ТА ЙОГО ЗНАЧЕННЯ У ВНУТРІШНІЙ ПОЛІТИЦІ ПОЛЬЩІ Й МІЖНАРОДНИХ ВІДНОСИНАХ
Authors: Kulyk Sergii
Published: March 2020

У Польщі є два політичні жести, які знає кожен. Перший  –  це  пальці  у  формі  літери «V», жест, відомий із часів «Солідарності». Другий, найпомітніший в історії польського спорту, – це жест Козакевича (пол. – gest Kozakiewicza), продемонстрований на Олімпійських іграх у Москві 1980 р. Влада СРСР і соціалістичної Польщі не надала публічного розголосу ні жесту, ні історії довкола нього. Під час «холодної» війни спортсмени з багатьох країн світу сприймали спортсменів із СРСР не лише як своїх суперників у змаганнях, але і як політичних, ідеологічних, культурних недругів. Тому жест у півруки відомого польського стрибуна із жердиною В. Козакевича, який він показав уболівальникам і суддям на стадіоні в Лужниках, зумовив підняття національного духу в Польщі, став символом визволення від комуністичного режиму. Політична реакція вищого партійного керівництва СРСР на жест польського атлета спростувала гасло, яким активно маніпулювала на міжнародній арені – спорт поза політикою. Здійснено спробу переосмислити значення жесту В. Козакевича в сучасних суспільно-політичних умовах, тому звертаємо увагу, насамперед, на: 1) політичний контекст іменного «жесту Козакевича»; 2) реакцію влади СРСР і ПНР щодо виступу спортсмена; 3) використання жесту як символу у внутрішньополітичній боротьбі у ПНР та проти СРСР; 4) політичні утиски В. Козакевича як відомого спортсмена; 5) використання В. Козакевичем історії свого жесту для створення особистого іміджу, у власній передвиборчій кампанії; 6) уживання вислову «жест Козакевича» у сучасній польській пресі та його значення. Доведено, що «жест Козакевича» з іменного перетворився на політичний, національний і міжнародний жест, він став універсальним у польській журналістиці.
ПРОЦЕС РЕГІОНАЛІЗАЦІЇ У ВЕЛИКІЙ БРИТАНІЇ
Authors: Gursky Taras , Kotsan Natalia
Published: March 2020

Здійснено аналіз процесу регіоналізації у Великій Британії. Визначено основні сучасні тенденції регіоналізації та їх роль у політичних процесах Великої Британії. Розглянуто позитивні зрушення в британському суспільстві, причиною яких стало розширення кола владних компетенцій місцевих органів. Установлено, що регіоналізацію можна розглядати як результат загального процесу кризи держави, що виражається в дифузії влади, тобто вона переходить як вверх – до транснаціональних організацій, так і вниз – до регіонів та інститутів громадської спільноти. Загальні причини регіоналізації виступають у прагненні зробити владу більш ефективною, перекласти на регіональну владу частину повноважень за прийняття рішень, задовольнити потреби тих чи інших прошарків суспільства до самоуправління. Висвітлено те, що проблема регіоналізації всередині країни виникає на сьогодні в багатьох країнах на основі ідей автономії, спираючись на історію, географію, культуру та інші шляхи, які йдуть вглиб століть та тисячоліть. Однак, саме зараз створюються зручні умови для розповсюдження самої ідеї регіоналізації, відродження подібних процесів із новою силою, на які діють численні каталізатори, головним із яких виступає глобалізація. Національні меншини продовжують заявляти про свою роль й отримують активну підтримку та захист зі сторони міжнародного співтовариства, твердо спираючись на норми міжнародного права, використовуючи можливість донести свою позицію до світової спільноти й об’єднати однодумців, використовуючи всі можливі засоби.
THE CONCEPT OF THE RESIDUAL LIFE OF THE BUILDINGS AT THE EXAMINATION OF INDUSTRIAL SAFETY
Authors: Kanunnikov Aleksandr , Buzalo Nina
Published: March 2020

The requirements of the rules for conducting an industrial safety expertise have established a mandatory definition of the residual life of buildings, however, to date, there is no exact definition of this notion. As a result, various methods of its calculation have their own unique interpretations, often contradicting each other. The situation is further aggravated by the need to clarify the results to owners of hazardous production facilities, who have their own idea of the life of buildings and the possibility of their further operation.

In the framework of this work, the authors consider the main factors that cause various interpretations of the concept of “residual life of buildings”, and also a definition is proposed allowing them to be excluded.
CRITERIA EVALUATION OF THE LIMIT DEPTH OF HORIZONTAL PRODUCTION
Authors: Bogomolova Oksana , Bogomolov Aleksandr
Published: March 2020

The paper presents the results of a study to determine the technological contours of horizontal underground workings and the maximum safe depth of their laying. The criterion for determining the limiting depth can be the condition that there are no points on the output circuit at which the stresses the tangential normal stress exceeds the tensile and compressive strengths of the host rock. The results of solving the problem of finding fracture zones on a circular cross-section working circuit are in satisfactory qualitative agreement with the result obtained independently of the authors.
UNDERSTANDING BEHAVIOR OF DIGITAL MONEY APPLICATION USAGE ON ADOLESCENTS
Authors: Pratika Yeyen
Published: March 2020

Information technology has changed the existing transaction process from

manual to digital-based. The presence of financial technology, especially

digital money drives to the high competition. Companies apply various

marketing strategies to win the market competition. The mechanism of

cashback promotion is mostly provided by digital money companies as their marketing strategies to attract customers. Cashback promotion program triggers a change of customer behavior to use digital money due to cashback promotion. This study aims to examine the factors that influence the use of digital money application on adolescents by using hedonic and utilitarian motivation, behavior aspect, intention to use and usage behavior. This studies used path analysis by utilizing the SmartPLS program. This study involved 113 respondents who have digital money application on their smartphone. The result found that hedonic motivation, utilitarian motivation and behavior aspect have a positive effect on the intention of use. In addition, intention of use also has a positive influence on usage behavior.
HOW COMPENSATION AND MOTIVATION GIVE IMPACT TO EMPLOYEE PERFORMANCE?
Authors: Achmad Gusti Noorlitaria , Adrianto Tedy , Riyanto Feri Djoko , Saman Anton
Published: March 2020

The success of a company is influenced by employee performance. By improving employee performance will make it easier for company goals to be achieved. One factor that can improve employee performance is the provision of compensation and motivation. This study aims to determine and analyze the effect of compensation and work motivation on employee performance. The sampling technique used is by taking a purposive sampling. The method used in this research is data collection through questionnaires, literature study, and observation. The technique used to analyze simple linear regression data and examine hypotheses simultaneously and partially. The result is compensation and motivation significantly influence employee performance simultaneously.
EMPLOYEE PERFORMANCE IN PT BPD KALTIM KALTARA SAMARINDA
Authors: Fajrina Nabila Nur , Militina Theresia , Achmad Gusti Noorlitaria
Published: March 2020

In this study involving PT BPD Kaltim Kaltara Samarinda. In this study, to see the performance of employees used a sample of 162 respondents, based on the results of the questionnaire that has been distributed, it can be seen that the number of respondents to be analyzed was 162 respondents. The data analysis used by the author is the Structural Equation Model (SEM). Hypothesis testing is done by multivariate analysis carried out through the WarpPLS program. Data analysis through partial Least Square (PLS) is done through two stages, namely: First, Assessing the outer model or measurement model. Second, assess the inner model or structural model.

The results showed that there was a positive and not significant effect between Openness on employee organizational citizenship behavior, There was a positive and significant effect between Conscientiousness on organizational citizenship behavior of employees, There was a positive and insignificant effect between Extraversion on organizational citizenship behavior of employees, There was an influence a positive and significant relationship between Agreeableness on organizational citizenship behavior of employees, There is a positive and significant influence between Neuroticism on organizational citizenship behavior of employees, There is a positive and insignificant effect between Openness on employee performance, There is a positive and insignificant effect between Conscientiousness on performance employees, There is a positive and significant influence between Extraversion on employee performance, There is a positive and significant effect between Agreeabl eness on employee performance, There is a positive and insignificant influence between Neuroticism on employee performance, There is a positive and not significant effect between organizational citizenship behavior on employee performance of PT BPD Kaltim Kaltara Samarinda Branch.
EFFECT OF SERVICE QUALITY AND BRAND TRUST ON CUSTOMER SATISFACTION AND CUSTOMER LOYALTY PERTAMINA HOSPITAL BALIKPAPAN
Authors: Wulur Lenny Meitha , Militina Theresia , Achmad Gusti Norlitaria
Published: March 2020

This research was conducted by Lenny titled "The Effect of Service Quality and Brand Trust on Customer Satisfaction and Customer Loyalty Balikpapan Pertamina Hospital" under the guidance of Prof. Dr. Theresia Militina, M.Siand Dr. Gusti Noorlitaria. A., SE., MM.

This study aimed to analyze the influence of service quality and brand trust to customer satisfaction and customer loyalty. The sampling method used in this study is nonprobability Sampling. The sample used in this study were a total of 110 respondents. Analysis of the data used in this study is Partial Least Square with the help of software SmartPLS3.0.

result This research shows: (1) Service Quality (X1) positive and significant impact on Customer Satisfaction (Y1), (2) Brand Trust (X2) positive and significant impact on Customer Satisfaction (Y1), (3) Service Quality (X1) positive and significant impact on Customer Loyalty (Y2), (4) Brand Trust (X2) has positive effect but not significant to Customer Loyalty (Y2), (5) Customer Satisfaction (Y1) positive and significant impact on Customer Loyalty (Y2).
HEALTH WATER MANAGEMENT SYSTEM IN URBAN AREA
Authors: Budi Agustyarum Pradiska , Junaedi Junaedi
Published: March 2020

Conservation of water resources in Indonesia is based on the management of springs on a large scale or in terms of water production. The approach that is often used is management from the demand side so that the mindset of the people is still trapped that water resources are free goods that can be taken without having to renew them again. This research tries to achieve direct community participation to participate in realizing and managing water resources directly.

Community participation techniques use advice on implementing policies to improve water resources. The policies offered include infiltration wells, biopori, and reforestation. The policy offer is the right alternative for households/communities directly. The purpose of this study is divided into 3, namely knowing the level of community WTP, knowing the variables that affect the WTP and preference analysis of alternative policy choices.

The results of the analysis show that the WTP level of the city of Surakarta is still low, which is equal to WTP ≤ Rp. 50,000. Policy variables can influence the level of willingness to pay by 42.60% compared to other variables only able to influence by 15.95% calculated using multinomial logistic regression. The results of the Analytical Hierarchy Process (AHP) analysis show that the ranking 1 weighting is the infiltration well policy.
THE ROLE OF PROFIT-LOSS SHARING IN DEVELOPMENT of MSMEs
Authors: Afkar Taudlikhul , Utomo Sigit Prihanto , Miradji Moch Afrizal , Hariawan Ferry
Published: March 2020

This study provides an overview of the development of MSMEs from the perceptions of MSMEs, not from the perspective of Islamic financial institutions. The purpose of this study is to show the development model of MSMEs through a profit-loss sharing agreement that is applied to the type of bound investment. It is applied in the mudharabah muqayyadah contract through the principle of profit sharing distribution. The method used in this study is a survey of MSMEs. The results of this study indicate that the development of MSMEs can be carried out with a mudharabah muqayyadah agreement through the principle of profit sharing distribution. To develop MSMEs in order to gain increased revenue, enlarge business scale, and diversify businesses, there needs to be a fair distribution of profit-loss sharing with the principles of revenue sharing, profit sharing, and agreed risk builders despite restrictions in business management such as the type of business determined by the owner of the fund, there are limits in the management of funds, as well as restrictions in running a business or investment, where businesses run must be guided by sharia principles
CACING TANAH (Lumbricus rubellus) SEBAGAI UMPAN ALTERNATIF DAN KARAKTERISTIK KESUKAAN IKAN HASIL TANGKAPAN PANCING ULUR (Hand line) DI PERAIRAN TELUK PALABUHANRATU
Authors: Saisar Fazri , Zulkarnain  , Mawardi Wazir , Apriliani Izza Mahdiana
Published: March 2020

Penelitian ini bertujuan untuk membandingkan hasil tangkapan pancing ulur (hand line) dan karakteristik kesukaannya terhadap penggunaan jenis umpan cacing tanah (Lumbricus rubellus) dan umpan ikan tembang (Sardinella fimbriata) yang biasa digunakan oleh nelayan di Teluk Palabuhanratu sebagai kontrol. Penelitian ini menerapkan metode uji coba penangkapan (experimental fishing) dengan 19 kali ulangan (trip). Komposisi hasil tangkapan terdiri atas 6 jenis ikan dengan jumlah total berjumlah 157 ekor yang didominasi oleh ikan layang (Decapterus kurroides) sebanyak 81 ekor (51,26%), swanggi (Priacanthus tayenus) sebanyak 42 ekor (26,58%), kurisi (Nemipterus hexodon) sebanyak 21 ekor  (12,29%), kuwe (Caranx sp) sebanyak 10 ekor (6,33%), petek (Leiognathus sp) sebanyak 2 ekor (1,26%) dan barakuda (Sphyraena sp) sebanyak 1 ekor (0,63%). Perbandingan hasil tangkapan pancing ulur berbeda pada setiap perlakuan dengan menggunakan kedua jenis umpan. Pancing ulur dengan menggunakan umpan ikan tembang memberikan jumlah hasil tangkapan sebanyak 93 ekor (59,2%). Sedangkan pada pancing ulur menggunakan umpan cacing tanah memberikan hasil tangkapan sebanyak 64 ekor (40,8%). Perbandingan total hasil tangkapan dari kedua jenis umpan memberikan pengaruh yang signifikan pada taraf (α) = 5%.

Kata kunci: cacing tanah, komposisi hasil tangkapan, umpan, pancing ulur
Laporan Kasus: Sindrom Bruns pada Neurosistiserkosis Intraventrikuler
Authors: Naryana Kadek Agus Sudha , Susilawathi Ni Made , Sudewi Anak Agung Raka
Published: March 2020

Latar Belakang: Sindrom Bruns adalah sekumpulan gejala peningkatan intrakranial seperti nyeri kepala, vertigo, dan muntah yang bersifat periodik dan dipicu oleh perubahan posisi kepala.

Kasus: Laki-laki 38 tahun, suku Bali datang ke rumah sakit dengan keluhan pusing bergoyang selama dua bulan dan memberat dalam dua minggu terakhir, disertai muntah dan nyeri pada kepala yang bersifat periodik. Pemeriksaan fisik menunjukkan vertigo tipe sentral yang bersifat periodik. Pemeriksaan laboratorium darah normal, pemeriksaan feses tidak ditemukan telur cacing, dan tes serologi positif. Pemeriksaan pencitraan kepala menunjukkan hidrosefalus, kalsifikasi multipel parenkim, dan lesi kistik soliter di ventrikel empat. Pemberian albendazole dan kortikosteroid selama 10 hari menunjukkan perbaikan klinis.

Diskusi: Kista neurosistiserkosis dapat ditemukan di ventrikel empat ( 43%-70%), ventrikel lateral (11%-43%), dan ventrikel ketiga (1%-29%). Kista yang bergerak bebas di sistem ventrikel dapat menimbulkan hidrosefalus yang bersifat periodik.

Simpulan: Manifestasi neurosistiserkosis intraventrikuler yang jarang dapat berupa Sindrom Bruns. Penegakan diagnosis pada Sindrom Bruns memerlukan MRI kepala.

Kata Kunci: Sindrom Bruns, Neurosistiserkosis Intraventrikuler, Hidrosefalus
Gambaran Pengetahuan dan Perilaku Masyarakat Tentang Epilepsi di Kecamatan Kewapante, Kabupaten Sikka
Authors: Suryawijaya Nathasia , Sam Candida Isabel Lopes , Gelgel Anna Marita
Published: March 2020

Latar belakang: Rendahnya pengetahuan masyarakat akan epilepsi berpengaruh buruk terhadap kualitas hidup penyandang epilepsi.

Tujuan: Untuk mengetahui gambaran pengetahuan dan perilaku masyarakat Kecamatan Kewapante terhadap epilepsi.

Metode Penelitian: Studi deskriptif terhadap 160 orang pada bulan September – November 2018 di Kecamatan Kewapante dengan teknik cluster random sampling dan menggunakan kuesioner.

Hasil: Dari 160 responden, 70.6% berjenis kelamin perempuan, 38.1% berpendidikan terakhir tamat SD, 29% berada dalam kelompok usia 26 – 35 tahun, dan 30% bekerja sebagai ibu rumah tangga. Seluruh responden pernah mendengar atau mengetahui mengenai epilepsi, dan 68.1% pernah melihat serangan epilepsi. Sebanyak 60.6% mengatakan gangguan saraf sebagai penyebab epilepsi dan 66.3% percaya epilepsi dapat disembuhkan. Seluruh responden mengetahui serangan epilepsi sebagai kejang. Sekitar 61.9% responden keberatan jika anak mereka berinteraksi dengan penyandang epilepsi, 79.4% menolak anggota keluarga mereka menikah dengan penyandang epilepsi, 68.1% melarang penyandang epilepsi memiliki pekerjaan yang sama dengan orang lain, dan 71.9% menganggap penyandang epilepsi boleh memiliki anak.

Simpulan

Seluruh responden warga Kecamatan Kewapante mengetahui serangan epilepsi sebagai kejang, namun perilaku masyarakat terhadap penyandang epilepsi masih beragam. Diperlukan penyebaran edukasi lebih lanjut mengenai epilepsi.

Kata kunci: Epilepsi; Pengetahuan; Perilaku
Laporan Kasus: Tetanus Tipe General pada Usia Tua Tanpa Vaksinasi
Authors: Clarissa Tertia  , I Ketut Sumada  , Ni Ketut Candra Wiratmi
Published: March 2020

Latar Belakang: Tetanus disebabkan toksin diproduksi bakteri C.tetani yang mengancam nyawa dan menjadi masalah kesehatan dunia. Kurangnya pengetahuan mengenai resiko infeksi tetanus menyebabkan masyarakat meremehkan luka yang berpotensi tetanus.

Kasus: Wanita, 89 tahun datang ke unit gawat darurat dengan keluhan trismus, kekakuan seluruh tubuh terutama bagian leher, disfagia, dan nyeri pada perut dan punggung punggung, riwayat demam, dan telapak kaki kanan tertusuk kayu 5 hari SMRS tanpa injeksi anti-tetanus. Riwayat kejang dan vaksinasi tetanus disangkal. Pasien kompos mentis, gelisah dengan nyeri berat. Trismus 1cm, risus sardonikus, meningismus, uji spatula positif, opistotonos, disertai perut seperti papan. Luka 2x1cm disertai nanah pada plantar pedis dextra. Pasien diberikan anti-tetanus serum, ampicillin sulbactam, metronidazole, dan terapi simptomatik lainnya. Pada hari ke-2 perawatan, terdapat kejang umum tonik dan terdapat perburukan dan pasien dinyatakan meninggal.

Diskusi: Manifestasi klinis pada tetanus disebabkan oleh tetanolisin dan tetanospasmin yang berikatan dengan sinaptobrevin/vesicle-associated membrane protein (VAMP), menyebar retrograde ke lower motor neuron kemudian berikatan dengan inhibitor-GABA. Port d entry pada kasus, luka tertusuk kayu dengan tetanus derajat III. Skor Dakar dan Phillips pasien 5 dan 20 (severitas sangat berat, mortalitas >50%).

Kesimpulan: Prognosis penyakit tetanus bervariasi tergantung usia, masa inkubasi, klinis, dan komplikasi, sehingga diperlukan diagnosis dan tatalaksana sedini.

Kata Kunci: tetanus, C.tetani, toksin, GABA, spasme otot
A Tool Development for Test Case Based Code Optimization in Java
Authors: TAYMAZ Turgay , BİRANT Kökten Ulaş
Published: March 2020

Java has been a popular programming language since its first stable release in 1996 because of its platform independence. Along with its popularity Java has been a focus of performance studies since its debut. Developments in hardware has unbelievably advanced the performance of the devices that run Java and thus software performance has lost its popularity until the release of Android OS and rapid increase in mobile device ownership Java language usage has increased once again. Mobile devices having far less system resources compared to personal computers had re-brought software performance studies into the spotlight. However mobile devices have gone into a fast-paced development like all other information technologies and this brought down the need for software performance studies, again. Also, worth mentioning that development of new Java Virtual Machine (JVM) versions has made the specialized compiler studies, which may threaten the platform independency, obsolete except for specific situations. Today it is not enough to consider code optimization solely in terms of performance improvement. Much broader vision is needed like software development processes such as Maintainability, code readability, improving cooperation in multi-programmer projects, software quality assurance.In this study, white box testing approach is adopted as the software testing technique and static code analysis method is selected to ensure line coverage. A new software (JPA) has been developed based on a currently used testing tool (PMD) to improve the user experience.
Pemanfaatan Ampas Tebu Sebagai Pembangkit Listrik Biomassa Di PG. Sragi Pekalongan
Authors: Amin Muhammad Chaerul , Taufiq Arif Johar , Kurniawan Itmi Hidayat
Published: March 2020

Seiring perkembangan zaman, dunia kini menuntut terpenuhinya aspekkecepatan, ketepatan, dan efisiensi sehingga semua pihak dituntut untuk terusmenghasilkan inovasi terbaru dengan teknologi mutakhir yang akanmengarah pada peningkatan permintaan energi listrik. Namun masalahutamanya adalah dalam bisnis penyediaan energi listrik yang masih sangatbergantung pada bahan bakar fosil, yang semakin menipis. Dengan kondisiini, pengadaan energi alternatif dan terbarukan baru, efisien dan ramahlingkungan sangat diperlukan. Misalnya adalah ampas tebu. Hingga saat ini,ampas tebu hanya digunakan sebagai pakan ternak atau bahan pupuk danpembuatan batu bata. Namun, dengan semakin berkembangnya arealperkebunan tebu dan didukung oleh penelitian tentang kandungan kaloriampas tebu, maka penggunaan ampas tebu sebagai bahan bakar dimulai.Setiap kilogram ampas tebu dengan kadar gula sekitar 2,5% memiliki panas1825 kkal. Pada penelitian ini, dilakukan audit energi dan pengamatantentang penggunaan ampas tebu sebagai bahan bakar pembangkitan listrik diPabrik Gula Sragi Pekalongan menggunakan aplikasi Homer. Hasilpenelitian menunjukan potensi ampas tebu 14,363 ton/jam secara teori yangsudah dikonversikan menjadi energi listrik sebesar 30,48 MW dengan nilaikalori 26.214.300 kkalori. Pada hasil simulasi menggunakan softwarehomer energy mendapatkan nilai ampas tebu pertahunnya pada saat musimgiling sebesar 5.725 ton/tahun dan telah dikonversikan menjadi energi listriksebesar 2.204.100 kWh/tahun dengan penerapannya menggunakan generator2 MW.
Alat Pengukur Suhu Badan Dan Detak Jantung Portable
Authors: Jatmiko Pandu Igeng , Taufiq Arif Johar , Dwiono Wakhyu
Published: March 2020

Menjaga kesehatan merupakan hal yang sangat penting bagi kehidupan. Kesehatan tubuh perlu diperhatikan bagi semua orang, terutama adalah kesehatan jantung. Jantung merupakan salah satu organ penting yang dimiliki oleh manusia yang berfungsi memompa darah ke seluruh. Detak jantung beats per menit (bpm) ini merupakan parameter untuk menunjukkan kondisi jantung. Selain jantung, yang harus diperhatikan adalah suhu badan. Perubahan suhu badan sangat erat kaitannya dengan produksi panas yang berlebihan, untuk mengetahui suhu badan diperlukan alat unutuk mengukurnya. Dalam kehidupan sehari-hari untuk mengukur suhu badan dan detak jantung harus menggunakan 2 alat ukur sehingga cukup menyulitkan, maka perlu adanya suatu alat yang dapat mengukur suhu badan dan detak jantung secara bersamaan. Alat ukur suhu badan dan detak jantung dirancang berbasis mikrokontroler AT-Mega328 menggunakan sensor DS18B20 sebagai pengukur suhu dan pulse sensor untuk mendeteksi detak jantung. Data detak jantung dan suhu tubuh ditampilkan pada LCD 16x2 dan data pengukuran disimpan pada memori mikro SD. Penelitian ini bertujuan untuk memudahkan dalam mengetahui suhu badan dan frekuensi detak jantung per menit. Selisih rata-rata antara DS18B20 dengan termometer digital adalah sebesar 0,71%. Pengukuran detak jantung menggunakan pulse sensor dan beat per minute tensimeter selisihnya sebesar 2,64%.
Investigating The Approaches of English Teachers in Fostering EFL Students’ Language proficiency
Authors: Anggraeni Anita , Rachmijati Cynantia
Published: March 2020

This research is qualitatively descriptive, intending to define the efforts of English teachers at Boarding school and hereinafter referred to as Pesantren (al-Fatah) to develop students’ English language proficiency. Subjects of this study are two English teachers and Students at Pesantren al-Falah. This study also investigates the way of English teaching methods or strategies in the classroom. There are two main instruments to collect data, those are Observation and interview guidelines. The result of the study indicates that the most teaching methods used are still a teacher-centered, direct method and habituation. This is due to the influence of the traditional Arabic learning model which is still largely focused on what is conveyed by the teacher in the classroom. But this Pesantren also implemented a communicative approach to develop the speaking skill of the students. One of the challenges faced is students' negative perceptions of English which assume that English is a western culture that is synonymous with negative things. Therefore, to further strengthen the development of English language skills, English teachers need to be more exposed to English by offering their students even more usual practice and the right media and literature to minimize negative perceptions of Western culture.
General Considerations on Clinical Trials of Hemophilia Medicines
Authors: Avdeeva Zh. I. , Soldatov A. A. , Bondarev V. P. , Merkulov V. A.
Published: March 2020

Hemophilia is an orphan disease associated with deficiency or complete lack of certain blood coagulation factors due to mutation of genes encoding their synthesis. Patients with hemophilia need continuous replacement therapy with coagulation factor products which are produced by recombinant DNA technology or derived from donated blood plasma. The development of new products or improvement of the production process of already authorised medicinal products involve clinical trials that have to include both previously treated and untreated patients of different age groups. The aim of the paper was to perform an analytical review of general hemophilia issues and major requirements for clinical trials of coagulation factor IX products based on the updated documents of the European Medicines Agency. The paper summarises the basic principles of conducting clinical trials of coagulation factor IX products that are submitted for marketing authorisation as “new” products, based on recommendations of Russian and international regulatory documents, including the updated guideline of the European Medicines Agency. It sums up product safety issues associated with undesirable immunogenicity resulting in formation of inhibitors that provoke allergic reactions or reduce the effectiveness of therapy. The harmonisation of the requirements for clinical trials during preparation and updating of documents by Russian manufacturers should be based on the analysis of the experience with hemophilia products and latest scientific achievements in the disease treatment. In that case it will facilitate the introduction of innovative efficacious hemophilia products into clinical practice.
Protecting Mice from H7 Avian Influenza Virus by Immunisation with a Recombinant Adenovirus Encoding Influenza A Virus Conserved Antigens
Authors: Sedova E. S. , Verkhovskaya L. V. , Artemova E. A. , Shcherbinin D. N. , Lysenko A. A. , Rudneva I. A. , Lyashko A. V. , Alekseeva S. A. , Esmagambetov I. B. , Timofeeva T. A. , Shmarov M. M.
Published: March 2020

Influenza is a highly contagious disease that causes annual epidemics and occasional pandemics. Birds are believed to be the source of newly emerging pandemic strains, including highly pathogenic avian influenza viruses of the subtype H7. The aim of the study: to evaluate the ability of the recombinant human adenovirus, serotype 5, which expresses genes of influenza A highly conserved antigens (ion channel M2 and nucleoprotein NP), to provide protection to laboratory mice against infection with a lethal dose of avian influenza virus, subtype H7. To achieve this goal, it was necessary to adapt influenza A virus, subtype H7 for reproduction in the lungs of mice, to characterise it, and to use it for evaluation of the protective properties of the recombinant adenovirus. Materials and methods: avian influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) was adapted for reproduction in the lungs of mice by repeated passages. The adapted strain was sequenced and assessed using hemagglutination test, EID50 and LD50 for laboratory mice. BALB/c mice were immunised once with Ad5-tet-M2NP adenovirus intranasally, and 21 days after the immunisation they were infected with a lethal dose (5 LD50) of influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) in order to assess the protective properties of the recombinant adenovirus. The level of viral shedding from the lungs of the infected mice was evaluated by titration of the lung homogenates in MDCK cell culture on days 3 and 6 after infection. The level of specific antibodies to H7 avian influenza virus was determined by indirect enzyme immunoassay. Results: the use of Ad5-tet-M2NP adenovirus for immunisation of the mice ensured 100% survival of the animals that had disease symptoms (weight loss) after their infection with the lethal dose (5 LD50) of H7 avian influenza virus. The study demonstrated a high post-vaccination level of humoral immune response to H7 avian influenza virus. The virus titer decreased significantly by day 6 in the lungs of mice that had been immunised with Ad5-tet-M2NP compared to the control group. Conclusion: the Ad5-tetM2NP recombinant adenovirus can be used to create a candidate pandemic influenza vaccine that would protect against avian influenza viruses, subtype H7, in particular.
Realizing Expectations from Planting Trees on Private Land in Ontario, Canada
Authors: MacDonald Heather , McKenney Daniel , McLaven Kerry , Perry Suzanne
Published: March 2020

This study explores the motivations behind participation in tree planting programs by private landowners in Ontario, Canada, as well as perceptions as to whether benefits were realized up to ten years after trees were planted. Forests Ontario, which has offered tree planting support programs in this province since 2007, provides up to 90% of the cost of seedlings for tree planting projects at least one hectare (ha) in size. This online survey of 570 former participants in tree planting programs indicated that a desire to create a habitat for wildlife (77.6%) was the most common motivation for taking part in a tree planting program. Concern with restoring native forest cover was also a reason for most participants (71.4%), as well as with improving soil, air and water quality (54.8%), and addressing climate change (54.3%). The most common benefit of planting trees was an increase in well-being and enjoyment of their property (67% of respondents). Overall, 27% of respondents with a desire to increase wildlife habitat, and 20% of those wishing to improve their local environment reported an improvement after tree planting. Reported improvements in the local environment and wildlife increased with time since tree planting, whereas enhanced well-being and enjoyment of the property were evident among participants even with newly planted trees.
KORELASI TEORI LOVE THY NEIGHBOUR DENGAN UNDANG-UNDANG REPUBLIK INDONESIA NOMOR 13 TAHUN 1998 TENTANG KESEJAHTERAAN LANJUT USIA
Authors: Michael Tomy
Published: March 2020

UU No. 13-1998 dapat terlaksana dengan baik dengan teori love thy neighbour karena di dalam undang-undang tersebut keimanan dan ketakwaan terhadap Tuhan Yang Maha Esa, kekeluargaan, keseimbangan, keserasian, dan keselarasan. Sehingga diperoleh hasil bahwa teori love thy neighbour tidak bertentangan dengan Pancasila dan dapat menunjang pelaksanaan UU No. 13-1998.Kata kunci: Â Love Thy Neighbour, UU No. 13-1998
Kepastian Hukum Sertifikat Hak Atas Tanah Berdasarkan Peraturan Pemerintah Nomor 24 Tahun 1997
Authors: Susanto Bronto
Published: March 2020

Abstrak. Pendaftaran tanah untuk pertama kali berdasarkan PP No. 24 Tahun 1997 tidak menggunakan sistem publikasi negatif murni, tetapi sistem publikasi negatif bertendensi positif. Walaupun demikian, tidak merubah makna bahwa sistem publikasi pendaftaran tanahnya adalah sistem publikasi negatif, artinya Negara tidak menjamin kebenaran data sertipikat, buku tanah, dan surat ukur. Sertipikat hak atas tanah merupakan surat tanda bukti hak yang kuat tetapi tidak mutlak, artinya sertipikat hak atas tanah menjamin kepastian hukum bagi pemiliknya sepanjang sertipikat tersebut: a) diterbitkan atas nama yang berhak, b) hak atas tanahnya diperoleh dengan itikat baik, c) dikuasai secara fisik, dan d) tidak ada pihak lain dapat yang membuktikan sebaliknya. Penelitian ini adalah penelitian hukum yuridis normatif yang bertujuan menganalisis, mengetahui dan memahami penyelenggaraan pendaftaran tanah untuk pertama kali berdasarkan PP No. 24 Tahun 1997 yang menganut sistem publikasi negatif bertendensi positif, dan kepastian hukum sertipikat hak atas tanah yang terbit berdasarkan PP No 24 Tahun 1997. Kata kunci : PP No. 24 Tahun 1997, Sertipikat Hak Atas Tanah, Pendaftaran Tanah
PEMBANGUNAN HUKUM INVESTASI DALAM PENINGKATAN PENANAMAN MODAL DI INDONESIA
Authors: Suradiyanto Suradiyanto , Warka Made
Published: March 2020

Abstrak:Â Penanaman modal suatu asing, sangat memepunyai peran yang penting, mengingatÂ  suatu Negara yang maju masing membutuhkan penanaman modal, apalagi suatau Negara yang sedang berkembang. Pemerintah Kabupaten dan Kota di seluruh Indonesia, menggali potensi daerahnya masing-masing dalam rangka melakukan promosi-promosi, sehingga akan dapat menarik gaerah penanaman modal dalam berinvestasi. Menindak lanjuti keinginan tersebut, maka Pemerintah Kabupaten/Kota masing-masing mengeluarkan Peraturan Daerah (disebutÂ  Perda), dalam rangka meningkatkan Pendapatan Asli Daerah (PAD), tanpa melihat kepentingan masyarakat serta dampak lainnya, Sasaran peningkatan PAD adalah masyarakat dan investor pada umumnya. atas kewenangan daerah Kabupaten/Kota, akhirnya berlomba-lomba mengeluarkan peraturan daerah (Perda) tanpa memperhitungkan aspek-aspek lainnya, yang dapat menghambat penanaman modal di wilayahnya masing-masing. Antara lain peraturan daerah tentang retribusi parkir, retribusi penerangan jalan dan perizinan bidang industri perdagangan dan penanaman modal.Keywords: Pembangunan Hukum Investasi, Peningkatan Penanaman ModalÂ
PENGUATAN SISTEM PRESIDENSIAL DALAM SISTEM KETATANEGARAAN INDONESIA
Authors: Hadi Syofyan
Published: March 2020

Furifikasi sistem presidensial dalam perubahan UUD NRI Tahun 1945 telah memberikan penguatan terhadap kedudukan Presiden. Namun demikian, furifikasi tersebut belum sepenuhnya memberikan penguatan, karena kewenangan presiden yang terlalu besar dalam bidang legislasi, lemahnya kewenangan legislasi DPD dan dianutnya sistem multipartai. Oleh karena itu, dalam rangka penguatan sistem presidensial perlu dilakukan perubahan, yakni penghapusan kewenangan legislasi Presiden, penguatan legislasi DPD, penyederhanaan partai politik dan pemilihan umum serentak
ESENSI ETIKA DALAM NORMA PEMBERHENTIAN PRESIDEN DAN/ATAU WAKIL PRESIDEN
Authors: Michael Tomy
Published: March 2020

Di dalam UUD NRI 1945 terdapat frase â€œperbuatan tercelaâ€ sebagai salah satu syarat untuk memberhentikan Presiden dan/atau Wakil Presiden menimbulkan ketidakjelasan norma. Hal lainnya yaitu memasukkan norma agama, norma kesusilaan dan norma adat ke dalamnya sebagai indikator perbuatan tercela. Hal ini membawa konsekuensi terhadap Presiden sebagai kepala eksekutif karena dengan adanya ketidakjelasan norma akan menimbulkan ketidakpastian hukum (muncul berbagai interpretasi). Di dalam mewujudkan indikator perbuatan tercela maka wajib menghilangkan perbuatan yang keberlakuannya dapat dinilai oleh masyarakat luas artinya di dalamnya harus mempersempit apakah yang dimaksud sebenarnya dengan perbuatan tercela.
PENEGAKAN HUKUM TERHADAP TINDAK KEKERASAN YANG DILAKUKAN OLEH SUAMI TERHADAP ISTRI
Authors: Warka Made , Dariati Dariati
Published: March 2020

Peristiwa kekerasan dalam rumah tangga (KDRT) didominasi oleh istri sebagai korban. Kekerasan dalam rumah tangga berkaitan erat dengan persoalan gender, adanya diskriminasi terhadap perempuan, serta diidentikkan dengan permasalahan pribadi dalam suatu keluarga. Kekerasan yang dilakukan oleh suami terhadap istri bukan hanya kekerasan fisik, tetapi juga kekerasan psikis, ekonomi dan seksual. Dengan berlakunya Undang-Undang Nomor 23 Tahun 2004, maka diharapkan penegakan hukum terhadap kekerasan yang dilakukan oleh suami terhadap istri dapat dilaksanakan secara maksimal. Baik dengan melakukan penanggulangan secara penal maupun non penal. Sehingga hambatan-hambatan dalam penyelesaian kekerasan yang dilakukan oleh suami terhadap istri dapat ditanggulangi. Penulisan bertujuan mengetahui pengaturan hukum kekerasan yang dilakukan oleh suami terhadap istri, serta faktor-faktor penyebab dan upaya penanggulangannya.
REDAKSI DAN DAFTAR ISI
Authors: Jurnal Ilmu Hukum DIH
Published: March 2020

ISSN: 0216-6534Â DIH â€“ JURNAL ILMU HUKUMÂ Â PenasehatKetua Umum Yayasan Perguruan Tinggi 17 Agustus 1945 SurabayaRektorÂ Penanggung JawabDekan Fakultas HukumÂ Pemimpin RedaksiKetua Program Doktor Ilmu HukumÂ Sekretaris RedaksiWiwik Afifah, S.Pi., S.H., M.H.Â Dewan PenyuntingProf. Dr. Made Warka, S.H., M.Hum.Dr. Soetanto Soephiady, S.H., M.H.Dr. Krisnadi Nasution, S.H., M.H.Dr. Hufron, S.H., M.H.Dr. Fajar Sugianto, S.H., M.H.Dr. Sri Setiadji, S.H., M.H.Â Mitra BestariProf. Dr. Mashudi, S.H., M.H. (Universitas Pasundan)Prof. Dr. Teguh Prasetyo, S.H., M.Si. (Universitas Kristen Satya Wacana Salatiga)Prof. Dr. I Dewa Gede Atmaja, S.H. (Universitas Udayana)Prof. Dr. Tjuk Wirawan, S.H. (Universitas Jember)Prof. Dr. IB. Supancana, S.H., M.H. (Central for Regulatory Research Jakarta)Dr. Gunarto Suhardi, S.H. (Universitas Katolik Atmajaya Yogyakarta)Prof. Dr. Zudan Arif F, S.H., M.H. (Kementerian Dalam Negeri Jakarta)Prof. Dr. I Nyoman Nurjaya, S.H., M.H. (Universitas Brawijaya)Dr. Harjono, S.H., M.C.L. (Universitas Airlangga)Dr. Kusnu Goesniadhi Slamet (Advokat/Surabaya)Â Pelaksana AdministrasiKasdi, S.Sos.; Suwasonoadi, S.E., M.M.Â PenerbitFakultas HukumUniversitas 17 Agustus 1945 SurabayaJl. Semolowaru 45 Surabaya Telp. 031-5905442; Email: fh@untag-sby.ac.id