bluuebunny/crossref_metadata_2025 huggingface dataset:
Use of MONTANIDE ISA 78 VG as adjuvant for the manufacture of antibacterial vaccines for chickens
Authors: Pankratov S. V.
Published: August 2024

Relevance. The use of antimicrobial agents and vaccine prophylaxis are the main ways to prevent and control most diseases of bacterial etiology. At the same time, uncontrolled use of antimicrobial agents without determining the sensitivity of microorganisms, as a rule, does not give the opportunity to obtain a positive therapeutic result. At the same time, a competently designed scheme of inactivated vaccine administration, taking into account the epizootic situation, is an effective and safe tool for controlling bacterial diseases.

In this regard, the results of testing of vaccine samples against bacterial diseases of birds based on the modernized oil adjuvant Montanide ISA 78 VG presented in this article are interesting and modern.

Methods. Four vaccine samples were manufactured for research based on the oil adjuvant Montanide ISA 78 VG. The first sample of the vaccine is against avian salmonellosis, the second — against avian pasteurellosis, the third — against avian respiratory mycoplasmosis, the fourth — against avian hemophilosis. All manufactured vaccine samples were investigated for sterility, stability and viscosity of the emulsion according to generally accepted methods. To determine the reactogenicity and antigenic activity of the vaccine samples, young egg-laying hens aged 25–40 days were used.

Results. Analysis of the obtained results of physical and biological properties of tested inactivated vaccines against bacterial diseases of birds allows us to conclude that the vaccine against respiratory mycoplasmosis of birds made on the basis of adjuvant Montanide ISA 78 VG is a safe and effective immunobiological preparation.
Concentration of kisspeptin, testosterone and cortisol in the blood of cows during the transit period with energy metabolism disorders
Authors: Shiryaev G. V. , Larkina T. A. , Nikitin G. S. , Prituzhalova A. O. , Shiryaeva N. A. , Perinek O. Yu. , Kurochkin A. A.
Published: August 2024

In the clinically healthy cows of the Holstein breed (n = 20), a hormonal background was studied during theperiod of deepness and after the edema. For this purpose, the concentration of kisspeptin, testosterone and cortisol was determined in serum cows in the blood cows. The animals conducted regular observation with the conduct of clinical and obstetric and gynecological studies. Depending on the concentration of glucose and beta-hydroxybutyric acid on the 5th day after calving, the cows were divided into two groups. The first group included 15 heads with a glucose concentration greater than 3 mmol/l and a beta-hydroxybutyric acid level below 1 mmol/l. In the second group, 5 heads had violations in energy exchange (glucose levels less than 3 mmol/l, beta-hydroxybutyric acid above 1 mmol/l). On the 15th day after the hotel, normalization of energy homeostasis was recorded. The concentration of kisspeptin in the preventive period in both groups decreased to the hotel. At the same time, the concentration of kisspeptin in the blood of animals in the group with energy exchange disorders was 2.4–3 times higher on the 9th, 7th and 5th days before calving (p < 0.01–0.05) compared with the first group. In production experience, the concentration of all three hormones after the hotel decreased with significant intergroup differences. The level of kisspeptin was reliably higher in the preventive period in the experimental group and on the 5th day after the hotel (p < 0.05). The cortisole level was held at a high level of up to 7 days after the hotel (p < 0.05). The concentration of testosterone in the blood throughout the transit period was reliably high in the animals of the experimental group.
Rationing of diets of dairy cows for non-degradable protein with protein supplements of plant origin
Authors: Golovin A. V.
Published: August 2024

Methods. This scientific and economic experiment was conducted under the conditions of the Moscow Region on 3 groups of Holstein breed cows showing milk yield of 8000 kg to study the efficiency of rationing of the content of non-degradable protein in feed rations for highly productive cows upon the use of various sources of protected plant-based protein.

Results. It was found that the increase in content of non-degradable protein from 35% in the control group to 40% in experimental groups I and II for the period from day 21 until day 100 of lactation by feeding corn gluten (0.85 kg) and extruded soy protein concentrate (1.0 kg) accordingly instead of sunflower meal (1.2 kg) in the control group, with the similar concentration of raw protein of 17.2% in dry matter of the feed, contributed to the increase in milk yield with 4% fat content over 100 days of lactation by 6.3% and 8.5% (p ≤ 0.05) and the increase in feed costs (ME) by 5.3–6.7%. In physiological studies, an increase in the digestibility of crude protein by 2.0% and 3.2% abs (p ≤ 0.05), in groups of cows receiving protected protein supplements, as well as a tendency for more intensive digestion of crude fat by 1.2% and 2.2% abs. (p ≤ 0.1). Economic calculations showed that the use of the studied protein supplements in the diets of animals of experimental groups I and II made it possible to reduce the cost of 1 c of milk with basic fat content by 41.8 and 56.0 rubles, while receiving additional profit in the amount of 2845.1 and 3861.3 rubles compared to control.
Experimental assessment of the relationship between the indigenous composition of the intestinal microflora and the elemental status of the common carp (Cyprinus caprio) against the background of the use of new feed additive
Authors: Sizentsov A. N. , Miroshnikova E. P. , Arinzhanov A. E. , Kilyakova Yu. V.
Published: August 2024

Relevance. Aquaculture is an intensively developing industry worldwide and is an important source of food for the population. Satisfaction of nutritional needs in micronutrients is a physiologically significant part of fish nutrition and, as a result, ensures their health. Currently, various approaches are being used to ensure the resistance of fish to diseases of various etiologies and to increase their productivity. One of the promising methodological approaches is the study of the fish microbiome as a sustainable alternative to improve aquaculture methods.

The aim of the study was to study the degree of relationship between the composition of the intestinal microflora and the level of essential elements in the body of carp (Cyprinus caprio) against the background of the use of feed additives “Bubitan” and “Intebio”.

Methods. The object of research was carp yearlings (n = 60) grown in the conditions of LLC “Irikla-fish” (Orenburg region). Feed additives “Intebio” and “Butitan” were used as growth and development regulating factors. Dynamic indicators of changes in the species composition of the intestinal microbiome and elemental status were carried out using metagenomic sequencing, atomic emission (NPP-ISP) and mass spectrometry (MS-ISP) methods.

Results.The data obtained indicate a significant effect of the tested phytobiotics on the indices of indigenous microflora. The closest indicators of the distribution of taxonomic groups of intestinal microbiocenosis in relation to the control were registered against the background of the use of the phytobiotic «Butitan». Correlation analysis of the data allows us to state with a high level of reliability that a significant increase in the number of microorganisms of the genus Hydrotalea and Flavobacterium has a positive effect on the degree of assimilation of macro- and microelements from the feed.
Web-Based User Center Design
Authors: Sufaidah Siti , Ahmadi Zuhal
Published: August 2024

Web-Based User Center Design is an e-commerce application that is engaged in conventional buying and selling serving the manufacture of t-shirts, jackets, shirts, uniforms, etc. With an existing design or customizing an existing design, the purpose of making a Web-Based User Center Design application is to build a special e-commerce application in the convection field for convection entrepreneurs, as for the benefits of making this e-commerce application, which is expected can make it easier to sell and promote its products so that it can increase turnover for convection entrepreneurs.
Classification of Prospective Students with Rapid Miner
Authors: Sifaunajah Agus , Wahyuningtyas Riesca Dewi
Published: August 2024

The application of information systems in various daily life processes results in data accumulation. Classification is a process in data mining to perform data analysis to generate models to describe the classes contained in the data. In this study, the ID3 Algorithm was used to classify prospective student data. This research employed a qualitative research model using the rapidminer tool application to carry out the classification process. Processed data is data obtained from surveys through google form media. The results of this study showed a classification model using the Interactive Dichotomizer Algorithm (id3), which can be developed into an information system for the admission of prospective students. It also revealed that data classification of students "cannot" or "can" at the foundation of the boarding school Bahrul Ulum Jombang in the form of a decision tree. Based on the decision tree, it was found that 50.72% (35 people) were classified as poor/incapable, and 49.27% â€‹â€‹(34 people) were classified as capable from a total of 69 data on prospective students.
Iot Based Heart Rate Detector Design
Authors: Sujono Sujono , Fuad Tsamrul
Published: August 2024

Heart rate is a very vital part of the human body, if the heart rate exceeds the maximum limit it will be very dangerous for the body. So we need a heart rate recording device that can store heart rate recording data so that it makes it easier to control health. This study aims to test the heart rate recording system with a comparison of a factory-made device, namely an oximeter. Making measuring instruments consists of making hardware and making software. In making hardware, several components are used, namely pulse sensors, NodeMCU, Oled and the device for making software is the Arduino IDE. Testing of the heart rate detection device is carried out by placing a pulse sensor at the tip of the finger to measure the heart rate of respondents of different ages. The test results show that the measuring tools that have been made show that manual calculations and using tools have fairly good accuracy. The results of the data obtained from the test were 60% (3 out of 5 people) who had the same heart rate using either a device or an oximeter. The average accuracy value of the heart rate recording system when compared to an oximeter is relatively small, namely 1-2 bpm.
Growth Analysis of Mahogany Seeds Using Android Based Seed Measurement Applications
Authors: Kholil Muhammad kholil asyari , Hartanti Dyah Ayu Sri , Widya Moh Anshori Aris
Published: August 2024

This mahogany seed measurement application is one of the systems used to simplify the analysis process for mahogany seeds. This application measurement is used to determine the development of mahogany seedlings when it's time to move. This research on making a simple application for measuring mahogany seeds which is not widely known by the wider community which has the potential to become one of the applications that are needed by Mahogany Farmers. This simple application receives an input in the form of data, then it is determined for various reasons so that these seeds are feasible to be moved to a more adequate place. The criteria for relocating were the small number of dead mahogany seedlings with a certain age, the height of the mahogany seeds and the good condition of the mahogany seeds. This research was conducted to make it easier for mahogany seed farmers to analyze the development or growth of mahogany seedlings and to make it more practical to use.
Optimization of Queries on Databases by Using the Ingres Algorithm
Authors: Nudin Nur lhsan , Sifaunajah Agus , Arifin Muhyiddin Zainul
Published: August 2024

Bahrul Ulum Islamic Boarding School is the oldest cottage in Jombang district which was founded in 1830 AD until now. which of course has a very large number of students, both students and alumni status. The author wishes to research how to manage data in information systems with hundreds or millions of data quickly and easily. Proper query design is very influential on information system applications, if you only rely on conventional query techniques, the results needed to process queries are relatively slow, and the time required is also longer. The purpose of this research is to optimize the query using the ingress algorithm which will later be tested and compared the results with queries that have not been optimized or conventional to determine the extent to which the query process can be accelerated. The experimental results show that the execution time is more effective and faster using an optimized command using the Ingres algorithm with an average processing time of 0.13226 seconds, and an average request that has not been optimized 0.2079 seconds, in other words the result is 65% faster than unoptimized queries.
Web-based Academic Information System Security
Authors: Hariono Tholib , Iqbal Muhammad , Yaqin Nurul , Ashoumi Hilyah
Published: August 2024

Web-based Academic Information System (SIA) has been used by all students of the Faculty of Information Technology KH. A. Wahab Unwaha Jombang University. Because all student academic records are stored through the campus network, it is necessary to conduct research on security so that a secure system is obtained. This research was conducted with steps including analysis and testing of installed systems, analyzing needs, designing problem solutions, making repair modules, installing modules and retesting repair modules. From the results of the research conducted, it can be concluded that there are weaknesses in the login system. The weaknesses include the use of the Student Identification Number (NIM) as the default username and password, username and password data is not encrypted before being sent to the server over the network, traces of usernames and passwords left in the browser as a cache or in the password manager can be seen as unencrypted plaintext. From the security analysis results, the SIA login system can be improved by applying HMAC MD5 encryption technology and Challenge Handshake Authentication Protocol (CHAP). Challenge is generated by the server randomly and used as a key in the HMAC MD5 encryption process. With the use of challenge passwords sent in the form of hash values will always be different in each session. Javascript on the client side is used to perform encryption so that the data before being sent to the server is already in an encrypted state.
Conversion Design of Arduino-Based Semi-Automatic Clothes Washer
Authors: Hariono Tholib , Indryanto Surya Puji , Munawarah Munawarah , Ashoumi Hilyah
Published: August 2024

This research aims to develop and evaluate a system that converts a manual clothes washer into an Arduino-based semi-automatic one. The research method used is a method of designing and creating a system for the object of research or called the design method. The system design is used as an object where the system is discussed and tested to find out how the system works and performs itself. The design object is an efficient and practical clothes washing tool.Converting a manual clothes washer into an Arduino-based semi-automatic one is an innovative and efficient solution to increase convenience and effectiveness in the clothes washing process. The design of this conversion model provides a complete guide to convert a manual washing machine into a semi-automatic one, improving the efficiency and convenience of daily use. With proper implementation, this project can provide an effective and cost-effective solution for household users.
Design Of Overheat Detection Device On Vehicle Engine Through Monitoring Water Temperature Or Cooling Oil
Authors: Nur Huda Erfan , Zulfikar Zulfikar
Published: August 2024

Currently, there is a cooling system in vehicle engines that uses additional cooling which warns the driver that the engine's working temperature has exceeded a predetermined threshold, but not for older vehicles or those that still use a CDI (Capacitor Discharge Ignition) system that only relies on the cooling system. through the fins on the machine. To overcome the problems described previously, research was carried out. The result of this research is a tool or device that can detect excessive heat in a vehicle engine using the DS18B20 sensor. The temperature sensor results are processed using an NodeMCU ESP8266 Lolin microcontroller to obtain information about engine temperature. This tool provides a warning system with fan commands and an LCD display that shows the condition of the engine's working temperature at that time. With this tool, overheating of the engine can be prevented.
PORTABLE CLOTHES WASHING MACHINE MODEL DESIGN ARDUINO BASED
Authors: Indryanto Surya Puji , Hariono Tholib
Published: August 2024

The development of electronic technology provides great benefits for the world of electronics and for everyday life. Single chip computers, also called microcontrollers or microcomputers, also provide technology so that many human aids can be created. One of the tools to complete human tasks is washing clothes. Washing clothes is a routine task that humans do almost every day. It is true that automatic clothes washing machines have been created and many people are already using them, but in some cases, for example, people who travel or stay outside the home will find it difficult to carry or own a conventional clothes washing machine because it is large and takes up space to store. The aim of making this tool is to make it easier and simpler for people to use a clothes washing machine and to carry it everywhere. By using the Arduino system, the washing machine which originally used a module was replaced with an Arduino which is definitely simpler to use. Portability Easy to carry and use anywhere, including in dorms, small apartments, or while traveling. Efficiency Saves air and energy compared to general washing machines. Easy to use and operate. Suitable for small clothes: Ideal for washing small and delicate clothes, such as underwear, socks and towels.
Information system for collecting data on the area of ​​irrigated rice fields at the Jombang district agricultural service
Authors: Azzahra Shafira , Zulfikar Zulfikar
Published: August 2024

Irrigation is one of the important elements in agriculture, especially in rice fields. Irrigation makes water more available to plants and can increase yields. Therefore, irrigation efficiency and monitoring are important to support agricultural productivity. Looking at the rapid development of technology utilization, it is also needed to help irrigation managers at the Department of Agriculture to collect data systematically. One of them is creating a data collection system in a more modern way. regarding the case of irrigation managers at the Department of Agriculture who have so far been using manual methods. The purpose of this study is to design an Information System for recording the area of ​​rice field irrigation. The SDLC (System development life cycle) method is used with a Waterfall process model: analysis, design, code generation, testing, and support. This system is created using PHP and MySQL programs, Google Chrome software, XAMPP, and MySQL database. The results of the study show that the designed system can help facilitate data collection on the area of ​​rice field irrigation at the Department of Agriculture, Jombang Regency.
Keywords: Information System; Data Collection; Irrigation; waterfall
Automatic Watering of Potted Plants Using Arduino-Based Real-Time Clock
Authors: Ihsan Hayatul , Zulfikar Zulfikar
Published: August 2024

In the era of rapid technological development, humans rely on tools and technology to make their work easier, making technology a basic need. This study aims to design a device for watering plants automatically with time settings. This tool uses RTC DS 3231 which functions to set the watering time that has been determined by the user and sends commands to the Arduino nano to turn on the bc547 transistor so that the pump can water according to the schedule that is set automatically. The research methodology is carried out by designing, creating, and implementing system components including Arduino nano as a controller, and bc547 transistor to turn the water pump on and off. The study's results prove that the tool made can function properly and be developed as expected by the researcher. This tool works automatically based on the watering time determined according to the user's wishes.
Data Visualization of Development Improvement and Budget Assistance for Village Residents Using the R Studio Program in Jombatan Village, Jombang District
Authors: Isrofi Isrofi , Zulfikar Zulfikar
Published: August 2024

Indonesia is a country that implements a regional self-government system, where each region is given the freedom to manage an exclusive area. This sovereignty does not only apply at the provincial and regional levels but also includes villages. Implementing "Law Number 6 of 2014 concerning Villages marks the beginning of a new era in village financial management". This law increases village income by allocating the Village Budget sourced from the State Budget (APBN). Village financial management is expected to be carried out more transparently, and accountably, and involve the population's participation. Village financial management includes all activities consisting of planning, implementation, management, reporting, and accountability of village finances.
Farmer Group Information System at the Jombang Regency Agriculture Service
Authors: Firdaus Thalisa , Zulfikar Zulfikar
Published: August 2024

The Jombang Regency Agriculture Service is one of the Regional Government Apparatus. The Agriculture Service has the task of assisting the Regent in government affairs and the Regional Government's authority in agriculture. In this case study, the following problems were found: the existence of agricultural extension workers whose performance was poor due to the lack of systematic monitoring. This study aimed to build an Information System for Agricultural Development Patterns in Jombang Regency. The results obtained were in the form of increased agricultural competitiveness in the era of the Industrial Revolution 4.0. With the sipotan system, the agriculture service can track, monitor, and identify regional potential by agricultural extension workers. With the sipotan system, it can be seen which extension workers are performing well and which are not.
ОБЛІКОВА І КОНТРОЛЬНА ФУНКЦІЇ В УПРАВЛІННІ ПРОЦЕСАМИ ОПТИМІЗАЦІЇ ЛОГІСТИЧНИХ ВИТРАТ НА ПІДПРИЄМСТВІ
Authors: Яремко І. Й.
Published: August 2024

Анотація. Розробка оперативного і стратегічного управління процесами оптимізації логістичних витрат спирається на той чи інший базис систематизованої внутрішньої та зовнішньої інформації, базову основу якої складають дані бухгалтерської системи та організованого на підприємстві внутрішнього контролю. Проаналізовано проблемні питання облікової і контрольної функції в управлінні логістичними витратами підприємства. Встановлено, що на обмеженість інформаційної функції бухгалтерського обліку в управлінні витратами на логістику впливають регламентовані методи узагальненого відображення такого типу витрат. Аргументовано, що інформаційна функція бухгалтерського обліку посилюється за рахунок відображення більш деталізованого і систематизованого складу логістичних витрат, що, у свою чергу, підвищує дієвість організованого на підприємстві контролю. Обґрунтовано необхідність формалізованого відображення логістичних витрат у бухгалтерській системі підприємства на основі удосконалення їх класифікації та розроблення відповідної методики їх відображення. Доведено, що впроваджений у практику розглядуваний управлінський інструментарій повинен бути акцентованим на ті інформаційні запити, які стають необхідними саме для впровадженого на підприємстві підходу до управління витратами і собівартістю. Наведено облікову і контрольну функції та інформаційне охоплення ними об’єктів і процесів при використанні підприємством як основи деяких концепцій управління витратами. Зроблено висновок, що існуючий бухгалтерський підхід до відображення логістичних витрат не може повноцінно забезпечити функції обліку та контролю в системі цілеорієнтованого управління. В концепціях сучасного управління дієвим визнається диференційований підхід до обробки даних про логістичні витрати, систематизованих у розрізі їх видів і за місцями виникнення.
СТАН ТА ПЕРСПЕКТИВИ РОЗВИТКУ ФОНДОВОГО РИНКУ З УРАХУВАННЯМ ОСТАННІХ ТЕНДЕНЦІЙ ТА ВИКЛИКІВ
Authors: Агрес О. Г. , Садура О. Б.
Published: August 2024

Анотація. У статті досліджується фондовий ринок як важлива складова сучасної економіки, відіграючи ключову роль у мобілізації капіталу, корпоративному управлінні та оцінюванні вартості активів. Метою статті є аналіз сучасного стану та перспективи розвитку фондового ринку з урахуванням останніх тенденцій та викликів. Визначено, що останніми роками спостерігається значне зростання його капіталізації, розширення спектра торгових інструментів та поява нових учасників ринку. В ході дослідження встановлено, що впродовж січня-грудня 2023 року основна частина торгівлі цінними паперами була зосереджена на двох операторах організованих ринків капіталу – “ПЕРСПЕКТИВА” та “ПФТС”, на які припадало 96,6% від загальної вартості угод з фінансовими інструментами. Виявлено, що сучасний фондовий ринок характеризується стрімким розвитком, появою нових інструментів та учасників, геополітичною нестабільністю, зростанням волатильності та стрімким розвитком нових фінансових технологій (фінтех). Важливим викликом на сьогодні є зміна поведінки інвесторів, що проявляється в таких аспектах: зростання ризикоаверсності, адже інвестори стають більш обережними та схильними до інвестування в консервативні активи, такі як депозити та облігації; короткострокове мислення (інвестори дедалі частіше прагнуть отримати швидкий прибуток, незважаючи на довгострокові перспективи розвитку компаній; недостатній рівень фінансової грамотності; вплив соціальних мереж, що може призвести до поширення дезінформації та необґрунтованих рекомендацій). Перспективи розвитку фондового ринку залишаються позитивними, що обумовлено низкою факторів, таких як зростання ролі інституційних інвесторів, розвиток онлайн-інвестування, поява нових інвестиційних інструментів (ETF, біржові облігації та деривативи), підвищення ролі ESG-інвестування. Реалізація цих перспектив залежить від низки факторів, таких як політична стабільність, сприятливий інвестиційний клімат та ефективне регулювання фондового ринку.
STUDY OF METHODS OF MEASURING SOCIAL RESPONSIBILITY OF BUSINESS IN THE SYSTEM OF SUSTAINABLE DEVELOPMENT OF THE REGION
Authors: Клюс Юлія , Ніжніков Ілля
Published: August 2024

The article proves that in modern conditions the sustainable development of regions is possible on the basis of the creation and development of institutions of coordination of interests between all the main participants of market relations: business, state, society. Business should assume responsibility for many areas of society development directly related to its economic activity (ecology, social programmes in the field of territorial development, improvement of the quality of life of the entire population: health care, labour protection, education, culture, sports). Analysis of the mechanisms of social responsibility implementation in practice shows that at the current stage of development socially responsible business behaviour should be elevated to the rank of the main direction of state policy. To achieve political, economic and social goals facing society, it is necessary to consistently implement large-scale measures to create social infrastructure in industrial regions, protect and expand the reproduction of natural resources, and create conditions for sustainable socio-economic development. The interrelationships of business social responsibility and sustainable development are studied, and priorities on the part of business and the territories of presence are identified. The experience is generalised and methodological approaches to macroeconomic assessment of damage and losses of the region's economy due to the environmental factor in accordance with different development scenarios are proposed. The theoretical foundations of the social responsibility of business as a system that naturally ensures the increase of socio-economic development of regions on the basis of the principles of sustainable development, necessity and sufficiency for sustainable development of the territory are developed; it is determined that the nature of compensation measures depends largely on the structure, functions and main directions of the implementation of social responsibility of business. A set of methodological approaches to the social assessment of business in the system of sustainable socio-economic development of the region
Radiographic evaluation of the healing process of alveolar abscess through regulation of VEGF and angiogenesis
Authors: Asykarie Ichda Nabiela Amiria , Epsilawati Lusi
Published: August 2024

Objectives: This review article aims to explain how the regulation of vascular endothelial growth factor (VEGF) and angiogenesis on alveolar abscess healing process evaluation using radiograph.
Review: The databases used in this review are Google Scholar, PubMed, and Science Direct. A total of  1280  search results appeared based on keywords. The search results were selected by title and abstract according to their relevance to the review topic. A total of 24 literatures were reviewed. The alveolar bone destruction is one of the signs of an inflammatory lesion in the alveolar bone. Bone damage that occurs in cases of the abscess will reduce the absorption of x-rays thereby giving a radiolucent appearance on radiographic examination. A radiographic examination is a supporting examination that can be used to develop the healing process. The processes of angiogenesis and osteogenesis of bone homeostasis will complement each other for the bone healing process, while VEGF is a growth factor that can increase the expression of BMPs and osteoblast differentiation so that the bone healing process can take place properly.
Conclusion: VEGF plays a significant role in both bone healing and regulation of vascular development and angiogenesis. However, excessive VEGF can also be harmful to the process of bone repair because it can stimulate the recruitment of osteoclasts. Therefore, VEGF regulation has an important role in apical abscess healing, and radiographic images that are quantitatively analyzed can be used to quantify this healing process.
Síncope como forma de presentación del tromboembolismo pulmonar masivo bilateral
Authors: Barcelay-Leyva Favián Alexis
Published: August 2024

El tromboembolismo pulmonar es una patología con una clínica variable, silente e inespecífica de difícil diagnósticoque representa un problema de salud de gran relevancia. Se presenta el caso de una paciente de 49años de edad, con antecedentes de ovalocitosis hereditaria, hipertensión arterial y fibromialgia primaria, que acudió al servicio de Urgencias por antecedentes recientes de pérdida del conocimiento. De acuerdo a losexámenes complementarios y estratificación de riesgo se concluyó: TEP masivo bilateral de riesgo intermediobajo.
Pericarditis purulenta tras realización de broncoscopia
Authors: Romeo-Allepuz Teresa , García-Domínguez Cristina , Urquízar-Ayen Fabiola , Martínez-Labuena Ana , Huertas-Puyuelo Ana Carmen
Published: August 2024

La pericarditis purulenta es una entidad muy poco frecuente con una mortalidad que con frecuencia superael 20% a pesar de la administración de un tratamiento adecuado. Presentamos aquí un caso de pericarditispurulenta por Streptococcus anginosus y Granulicatella adiacens tras la realización de una ecobroncoscopiadiagnóstica que inicialmente se manifestó como un taponamiento pericárdico y un shock séptico. Se lepracticó un drenaje pericárdico con una mejoría lenta, aunque progresiva. Sin embargo, el desarrollo de unapericarditis constrictiva obligó a la posterior realización de una pericardiectomía.
Reingreso hospitalario por insuficiencia cardiaca, ¿hay algo más?
Authors: De la Cueva-Genovés Daniel , Urbaneja-Zumaquero Víctor , Martín-Cortés Salvador
Published: August 2024

Hombre de 78 años con múltiples comorbilidades que presentó descompensación cardiaca recurrente a pesar de un tratamiento optimizado. Se realizó diagnóstico diferencial de las posibles causas de disnea refractaria, con diagnóstico de neumopatía intersticial y amiloidosis cardiaca. Se discutió la complejidad diagnóstica, destacando la amiloidosis cardiaca como un factor importante e infradiagnosticado. Finalmente, se resaltó la necesidad de una evaluación exhaustiva en casos clínicos con síntomas recurrentes/refractarios.
La nueva gobernanza instrumental del estado de bienestar. Transformaciones y retos
Authors:   Universidad de Guadalajara, Vargas Hernández José Guadalupe , Guerra García Ernesto , Valdez Zepeda Andrés
Published: August 2024

Este trabajo provee un marco de referencia para el análisis de los principales asuntos relacionados con la economía y la sociología del programa político denominado Estado de Bienestar (EB), sustentados en conceptos, teorías, métodos y resultados de las investigaciones empíricas desde una perspectiva económica y sociológica. El objetivo es construir un marco de referencia teórico-metodológico que facilite el análisis sociológico de instituciones de bienestar, localizar el campo de bienestar en la formación social y estudiar el grado de diferenciación que surge.
ACTIVITY OF SERUM ENZYMES OF YOUNG PIGS OF DIFFERENT GENOTYPES BY MELANOCORTIN RECEPTOR GENE (MC4R) AND THEIR RELATIONSHIP WITH FATTENING AND MEAT QUALITIES
Authors: Khalak Viktor , Gutyj Bohdan , Bordun Oleksandr
Published: August 2024

The article is devoted to studying the activity of serum enzymes, fattening, and meat qualities of young pigs of different genotypes by the melanocortin receptor gene MC4R, calculating the level of correlation between traits, and economic efficiency of research results. The experimental part of the research was carried out in the agricultural formations of the Dnipropetrovsk region, the Research Center for Biosafety and Environmental Control of Agricultural Resources of the Dnipro State Agrarian and Economic University, the Genetics Laboratory of the Institute of Pig Breeding and Agricultural Production of the National Academy of Agrarian Sciences of Ukraine and the Laboratory of Animal Husbandry of the State Institution “Institute of Grain Crops of the National Academy of Agrarian Sciences”. The work was carried out by the research program of the National Academy of Agrarian Sciences of Ukraine No. 30, ” Innovative Technologies of Breeding, Industrial and Organic Production of Pig Products,” task “To develop a local system of selection and hybridization of pigs using modern genetic methods (DNA markers)”. Laboratory studies and the results of control fattening indicate that the biochemical parameters of blood serum (activity of aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase) of young pigs of large white breed of the controlled population correspond to the physiological norm of clinically healthy animals, and according to the leading indicators of fattening and meat qualities (age of reaching body weight of 100 kg, days; fat thickness at the level of 6-7 thoracic vertebrae, mm; length of chilled carcass, cm) belongs to class I and class elite. Analysis of the data of control fattening and slaughter shows that young pigs of the second experimental group (MC4RAG) are superior to their peers of I (MC4RAA) in terms of average daily weight gain, age of body weight100 кг, fat thickness at the level of 6-7 thoracic vertebrae and length of chilled carcass by an average of 4.58%. Several significant associations between interior parameters (aspartate aminotransferase (AST) activity, units/l; alanine aminotransferase (ALT) activity, unit/l), fattening and meat qualities of young pigs of the controlled population is 28.57 %. This indicates the possibility of using interior indicators for early prediction of fattening and meat qualities of young pigs. The maximum increase in additional production was obtained from young pigs of the second experimental group (MC4RAG) – +3.24 %, and its cost, which was obtained from the sale of one head of young pigs of the specified genotype is equal to +261.56 UAH or +6.62 USD.
Evaluating the Effectiveness of Local Self-Government Websites with Use of Web Analytics
Authors:   National University of Water and Environmental Engineering, Vasyliv Volodymyr B. , Beztelesna Liudmyla I. ,   National University of Water and Environmental Engineering, Shvets Fedir D. ,   National University of Water and Environmental Engineering
Published: August 2024

In today’s world, websites have become an important channel of communication between local governments and citizens. Effective websites of local self-government bodies can help improve the provision of services to the population, raise citizens’ awareness of the government’s activities and stimulate citizens’ participation in decision-making. The aim of this study is to assess the effectiveness of the websites of local self-government of Rivne region with use of web analytics. The object of the study is 64 territorial communities of Rivne region. The study showed that the websites of local self-government in Rivne region have a number of problems that negatively affect their effectiveness. These problems include: 1) low attendance. Many local government websites have a low number of visitors, which indicates that they are not effective tools for informing citizens; 2) insufficient quality of content. The content on many local government websites is irrelevant, uninteresting and unpractical for users; 3) poor technical optimization. Many local government websites load slowly, are not optimized for mobile devices, and are not accessible to people with disabilities. However, the study also showed that the websites of rural and settlement communities have a higher traffic rate compared to urban communities. This may be due to the fact that in rural areas people have fewer alternative sources of information about the activities of the authorities. The study also identified a number of factors influencing the effectiveness of local government websites. These factors include: the relevance of the content; download speed; mobile optimization; user experience. The results of the study highlight the importance of an integrated approach to improving the effectiveness of local government websites. Local governments that want to have effective websites should improve the quality of content, optimize their websites technically, use SEO and social networks, and involve citizens in the development and improvement of their websites.
Anti-inflammatory and Antioxidant Activities of the Leaves of Rumex acetosa Ethanol Extract
Authors: Oluwasesan M. Bello , Aisha Ibrahim Saulawa , Saudat Muhammad Abubakar
Published: August 2024

To evaluate the antioxidant, anti-inflammatory, and Alzheimer’s activities of ethanol extract of Rumex acetosa (R. acetosa) leaves. In this context, the in vitro antioxidant activity was demonstrated by Flavonoid mg QE/g. Phenol mg GAE/g, Carotenoids µg/mL. The antiinflammatory activity was evaluated against heat, inhibiting the denaturation of albumin, cyclooxygenase, Lipo-oxygenase, nitric oxide production, and protease inhibition. The antiAlzheimer’s activity was evaluated by inhibition of acetylcholinesterase and butyrylcholinesterase assay and dopamine level. Total phenolic content was found respectively (48.79±1.71) while the positive control is 58.492 µg/ml (Gallic acid) mg gallic acid equivalent/g. The extract displayed significant inhibition of denaturation of albumin andprotease (43.56±0.27 and 48.15±0.38) respectively with the positive control employed being Aspirin (72.628 and 73.985). R. acetosa showed in vitro anti-inflammatory activity by inhibiting heat-induced albumin denaturation and protease inhibition. Our results show that ethanol leaf extract of R. acetosa has good antioxidant activity and interesting anti inflammatory properties but moderate Alzheimer’s properties. The medicinal plant can be used to prevent oxidative and inflammatory processes.
In silico Study of Secondary Metabolites from the Leaves of Rumex acetosa against Proteins associated with Inflammatory and Alzheimer
Authors: Suleiman Sani , Shehu Abdulsalam Shema , Oluwasesan M. Bello
Published: August 2024

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-beta (Aβ) peptides and hyperphosphorylated tau proteins, leading to neuronal loss and cognitive decline. The development of effective therapeutic interventions for AD remains a significant challenge. In this study, we performed an in-silico investigation to explore the potential of secondary metabolites derived from the leaves of Rumex acetosa as potential inhibitors of key proteins involved inAD pathogenesis. We first identified and characterized the major secondary metabolites present in sorrel leaves through a comprehensive literature review. Using molecular docking, we then evaluatedthe binding interactions between these phytochemicals and well-known AD-associated targets, including Aβ, tau protein, and acetylcholinesterase (AChE). The binding affinities, interaction patterns, and pharmacokinetic properties of the top-performing compounds were analyzed to assess theirpotential as drug candidates. Our results suggest that several sorrel leaf-derived secondary metabolites, such as rutin, quercetin, and kaempferol, exhibit promising binding interactions and favorable pharmacokinetic profiles against the studied AD targets. These findings provide valuable insights into the therapeutic potential of sorrel leaf extracts and highlight the need for further in-vitro and in-vivo validation to establish their efficacy in the treatment of Alzheimer's disease.
Lansia Berdaya Bangsa Sejahtera : Konsep Active Ageing terhadap Anak Muda Studi di Yogyakarta
Authors:   Prodi Ilmu Kesejahteraan Sosial, Fakultas Dakwah dan Komunikasi, UIN Sunan Kalijaga, Yogyakarta, Indonesia, Putri Alcyva Anindita Aisha , Hakim Lukman Nul ,   Pusat Riset Kesejahteraan Sosial, Desa dan Konektivitas, Badan Riset dan Inovasi Nasional (BRIN), Jakarta, Indonesia
Published: August 2024

Indonesia mengalami peningkatan pada struktur penduduk usia lanjut. Hal ini menyebabkan dampak positif dan negatif khususnya bagi keberlangsungan kehidupan bangsa. Lansia berdaya merupakan salah satu hal yang dapat meringankan kondisi bangsa untuk menjadi bangsa yang sejahtera. Konsep Active Ageing membawa bangsa Indonesia menjadi bangsa yang sejahtera. Konsep active ageing sendiri terdiri dari 8 faktor yang dibagi menjadi 2 bagian. Tentunya konsep ini akan berangkat sejak masa muda. Anak muda yang memahami konsep active ageing dapat menjadi lansia berdaya saat masa lanjut usia nanti. Hasil penelitian melalui metode statistic deskriptif ini penulis didapati bahwa anak muda memberikan hasil positif terhadap pengetahuan, sikap dan tindakan terhadap konsep active ageing tersebut. Bahwa Anak Muda sudah mengetahui pengaplikasian konsep active ageing dalam kehidupan sehari- hari mereka. Secara teori kebanyakan anak muda belum maksimal dalam pemahaman konsep active ageing ini. Untuk penerapan konsep active ageing harus terus diterapkan oleh anak muda dan diteruskan kepada generasi berikutnya. Pemerintah dalam hal ini dapat memberikan pendampingan dan pemberdayaan kepada remaja agar dapat menjadi individu yang produktif bahkan hingga masa lanjut usianya yang berdampak juga pada kesejahteraan bangsa Indonesia nantinya.
A labdarúgás oktatásának eredményessége az általános iskola 8. évfolyamában
Authors: Makkai Máté , Bognár József
Published: August 2024

A labdarúgás egy nagyon népszerű sportág hazánkban. Nem meglepő módon a testnevelés gyakorlati anyagának is szerves része. Bár a Nemzeti alaptanterv megengedi, hogy két másik sportjáték kerüljön feldolgozásra egy-egy tanév során, de a Testnevelési kerettanterv részletezi, milyen tartalmakat kell oktatni a labdarúgás területéről. Kutatásom azzal foglalkozik, hogy mennyire hatékony az labdarúgás-oktatás a Dr. Hesz Mihály Általános Iskola 8. osztályában. Az osztály létszáma 23 fő, amelyet 3 részben vizsgáltam: labdarúgó fiúk (N = 8 fő), nem labdarúgó fiúk (N = 5 fő), nem labdarúgó lányok (N = 10 fő). Három motoros (helyből távolugrás, törökülésből tizenöt méteres sprint, húszméteres ingafutás) és három labdarúgás-specifikus (célba rúgás, labdaemelgetés, szlalom labdavezetés) tesztet végeztettem el velük. Majd a labdarúgás tematikai egységem letanítása után újra elvégeztettem velük ugyanezeket a teszteket. A csoportok első teszten produkált egymáshoz viszonyított eredményeit kétmintás t-próba függvénnyel, a saját teljesítményfejlődésüket egymintás t-próbával vizsgáltam. Mindkét esetben a szignifikanciaszintnek a p < 0,05 értéket tekintettem. A labdarúgó fiúk a motoros tesztek tekintetében szignifikánsan jobban teljesítettek a nem labdarúgó lányoknál, a nem labdarúgó fiúknál átlagosan jobban, kivéve helyből távolugrásban. A sportágspecifikus teszteken átlagosan minden csoportnál jobban teljesítettek a labdarúgók, de szignifikáns eltérés a szlalom labdavezetés és labdaemelgetés tesztnél mutatható ki. A nem labdarúgó fiúk szignifikánsan jobban teljesítettek helyből távolugrásban, labdaemelgetésben és labdavezetésben, mint a lányok. A második teszten a labdarúgók szignifikánsan jobban teljesítettek labdavezetésben, labdaemelgetésben, törökülésből futásban, a lányok labdaemelgetésben, a nem labdarúgó fiúk bal lábbal történő célba rúgásban. Tematikus egységem tartalmait szükséges újragondolni. A kutatást érdemes lenne nagyobb populációra kiterjeszteni, hogy az eredmények jobban igazolhatók legyenek.
Kolajen Desteğinin Güncel Kullanım Alanları
Authors: Özmen Funda Büşra
Published: August 2024

Hücre dışı matrikste yüksek miktarda bulunan kolajen, son dönemde farmasötik, besin takviyesi ve kozmetik sektörlerin de gündemdedir. Kolajenin kaynakları, üretim teknikleri, kimyasal yapısı ve özelliklerine ilişkin artan bilgi, daha fazla kolajen bazlı ticari ürün ve biyomateryallerinin geliştirilmesine yardımcı olmuştur. Kolajen destekleri, özellikle yaşlanan insanlar için genel sağlığa fayda sağlamada önemli bir rol oynamaktadır. Bu yazıda cilt rejenerasyonu, kas-eklem-kemik sağlığı, sarkopeni, yara iyileşmesi ve osteoartrit gibi farklı klinik alanlarda kolajen desteğinin etkileri gözden geçirilmiştir. Değerlendirilen klinik çalışmalarda kolajen bazlı desteklerin, tanı almış hastalıkların tedavisinde ve komplikasyonları iyileştirmede yararlı olduğu sonucuna varılmıştır. Kolajen genel olarak güvenli bir besin desteği olarak görünse de farklı kaynaklardan elde edilen kolajenler için yüksek doz ve uzun süreli kullanımdaki etkilerini aydınlatmak amacıyla daha kapsamlı insan çalışmalarına ihtiyaç vardır.