bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceptions from Members-Consumers of a University Community for Sustainable and Healthy Eating: Evidence from Greece
Authors: Mastora Athina , Chatzitheodoridis Fotios , Skalkos Dimitris
Published: February 2024

Healthy eating is a vital component of a sustainable daily life, especially after the pandemic of COVID-19. In this study we investigated the perceptions and attitudes of the members of a Greek University community especially the young members of this on: i) health itself, ii) healthy eating, and iii) healthy eating campaigns today. The research was conducted in the last three months of 2023, via a questionnaire survey electronically, and 1406 members-consumers, participated. Sta-tistical analysis included descriptive and cluster analysis to group respondents into homogenous segments was performed by employing One-Way Anova. The highlights of the results indicate that consumers perceive physical, mental health and energy efficiency as health preconditions, while they perceive a balanced and sustainable diet as the main parameter of healthy eating. They are influenced mostly by doctors and health providers and use information mostly based on common sense and upbringing for their healthy eating choices. The cluster analysis revealed two distinctive groups of consumers categorized by this study as the “approachables”(54,5%) effected by the todays sustainable knowledge and concepts on healthy eating, and the “conservatives” (45,5%) who they reluctant to accepted these as such.
Sequence Fingerprints in HerA Helicase: Implications for DNA Repair and Cancer
Authors: Azam Sabiya , Anjum Rana Salman
Published: February 2024

In archaea, the interaction of HerA helicase and NurA nuclease is required for 3' end resection during DNA double-stranded break repair, and its disruption results in unfaithful DNA repair. Interactions transpire by the four conserved domains, including the N-terminal HAS domain (HerA-ATP synthase), which serves as a binding site for the exonuclease NurA. As a HerA hexamer between its two subunits, the conserved C-terminal brace extension functions as an adjacent brace. DBD serves as a location for DNA binding, which causes the DNA strands to be propelled into the HerA pocket to begin unwinding. The putative pore entrance is made up of four helix coils, which provide a suitable charged surface for guiding DNA into the pore. The crystal structure of the complex HerA-NurA allows for the identification of key residues for protein-protein interaction. This allows us to predict that most archaeal HerA orthologs will be able to interact with one another. Archaeal HerA is a homo-hexameric assembly featuring a DNA-binding domain that is conserved. It also features distinctive ATP and NurA binding domains. Following the structure and sequence conservation criteria, we find one HerA ortholog in Pyrobaculum calidifontis and multiple HerA paralogs, but the role of none is established yet.Interestingly, orthologous HerA is part of an Mre11-Rad50 gene neighborhood while paralogous HerA is not, which could be misleading. As a result, it sought to describe the criteria that may be used as a possible fingerprint for identifying orthologous genes, as well as the cloning procedures and tactics that would aid in the confirmation of the HerA helicase in P. calidifontis. Their confirmation is based on PCR cloning and characterization following HerA construct creation.
Effects of 2D Ultrasonic Vibration on Plasticity and Fracture Characteristic of 1060 Aluminium Alloy Sheet for Incremental Forming
Authors: Lv Yuan , Wang Yifan , Wang Yan , Pan Xixiang , Yi Cong , Dong Mengen
Published: February 2024

The 1060 aluminium alloy is widely applied to electronic industry, construction area, aerospace field, traffic engineering, decoration and consumption goods market for its good chemical, physical and mechanical properties. In general, excellent processing property is necessary and important for manufacturing of complicated panels. In this paper, a special 2D ultrasonic vibration incremental forming method is designed to improve its plasticity and mechanical properties. Three kind of processing methods including traditional single point incremental forming, longitudinal ultrasonic vibration incremental forming and 2D ultrasonic vibration incremental forming are conducted for flexible manufacture of conical parts of 1060 aluminium alloy sheet. Then micro-hardness tests, residual stress tests and scanning electron microscopy tests are carried out to probe its revolution of micro-structure and mechanical properties and to analysis the effects of different types of ultrasonic vibration on plasticity and fracture characteristic of 1060 aluminium alloy. It is proved that 2D ultrasonic vibration is facilitated to improvement of plasticity and surface qualities of 1060 aluminium alloy than the other two processing methods. So, the novel 2D ultrasonic vibration incremental forming possesses substantial application values on flexible and rapid manufacturing of complicated thin-walled component of aluminium alloy.
Fuzzy Modeling Framework Using Sector Non-Linearity Techniques for Fixed-Wing Aircrafts
Authors: Brusola P. , Garcia-Nieto Sergio , Salcedo Jose Vicente , Martínez Miguel , Bishop Robert H
Published: February 2024

This paper presents a mathematical modeling approach utilizing a fuzzy modeling framework for fixed wing aircraft systems with the goal of creating a highly desirable mathematical representation for model-based control design applications. The starting point is a mathematical model comprised of fifteen non-linear ordinary differential equations representing the dynamic and kinematic behavior applicable to a wide range of fixed wing aircraft systems. Here the proposed mathematical modeling framework is applied to the AIRBUS A310 model developed by ONERA. The proposed fuzzy modeling framework takes advantage of sector non-linearity techniquesto recast all the non-linear terms from the original model to a set of combined fuzzy rules. The result of this fuzzification is a more suitable mathematical description from the control system design point of view. Therefore, the combination of this fuzzy model and the wide range of control techniques available in the literature for such kind of models will enable us to avoid common control design methods, such as gain scheduling, where stability issues can be extremely challenging.
Mental Health Nursing Student’s Perception of Clinical Simulation about Patients at Risk of Suicide: A Qualitative Study
Authors: Del Pozo-Herce Pablo , Tovar-Reinoso Alberto , Martínez-Sabater Antonio , Chover-Sierra Elena , Pacheco-Tabuenca Teresa , Carrasco-Yubero Jorge , Sánchez-González Juan Luis , González-Fernández Silvia , Santolalla-Arnedo Iván , Sufrate-Sorzano Teresa , Juárez-Vela Raúl , García-Carpintero-Blas Eva
Published: February 2024

: Suicide is a serious public health problem, with a global mortality rate of 1.4% of all deaths worldwide, and the leading cause of unnatural death in Spain. The use of clinical simulation has proven to be a beneficial tool in the training of nursing students. Such experiences allow them to develop cognitive and affective skills that are fundamental for the detection of warning signs and use of interventions in cases of people who want to take their own lives. Working in a mental health environment can be difficult for nursing students; therefore, the purpose of this study was to explore the perceptions of nursing students on the approach, management and intervention of suicidal crisis through clinical mental health simulation. Methods: qualitative descriptive phenomenological study through focus groups and reflective narratives in a sample of 45 students. A thematic analysis was performed using ATLAS-ti. Results: After the analysis, three themes were obtained: (a) management and handling of emotions (b) identification of suicide motives (c) intervention in suicidal crisis. Discussion: Clinical simulation in mental health allows students to exercise clinical judgment reasoning, detect warning signs for a better treatment approach, and provide tools for effective intervention and management of patient care. The results of this study indicate that nursing students face challenges in approaching mental health clinical simulation due to lack of prior exposure.
Control Method of Load Sharing between AC Machine and Energy Storage Bank in the DC Grid
Authors: Kozak Maciej , Słodkowski Maciej , Sawicki Seweryn
Published: February 2024

The article presents the issues related to load sharing in direct current grid and a novel control method which has advantages over known solutions. Unlikely of many similar sounding papers this article shows attempt of creation fully controllable non-isolated system which allows load sharing between permanent magnet alternator equipped with machine side converter (MSC) and dual active bridge (DAB) tied to batteries or supercapacitor. The power sharing is essential feature of parallel connected direct current generators and all types of voltage sources in this way are contributing power to the system. Such system should have possibility of the rapid voltage build up in the case of sudden electrical load changes. To keep the optimal efficiency of the alternator the rotational speed changes according to proper mapping of driving combustion engine. When rotational speed is too low then sudden electrical load can cause significant voltage drop and time needed for voltage build up will vary according to RPM increase. In such situations the undervoltage system can trip the breaker and finally there may be a blackout. To avoid such problem the DC systems which consist of batteries and supercapacitor were introduced. System components include a self-excited synchronous generator (SESG) operating at variable shaft speed as well as batteries and supercapacitors that provide electricity for sudden electrical load changes on the distribution grid. The core of presented system is in power distribution method which consists of programmed controllers structure allowing precise currents distribution. A novelty in the proposed method is the use of a cascaded system of current and DC voltage regulators which allows power distribution precise control. In contrary to previously presented solutions, the proposed system allows fast and accurate control of currents loading parallel connected DC voltage sources for wide range generator speed changes. In presented solution both converters have been equipped with Schottky diodes preventing flow of equalizing currents between closed transistors in the parallel mode of operation. An experimental test-stand of the described system is presented with its theoretical basis and experimental results.
Sensory Integration: A Novel Approach for Healthy Ageing and Dementia Management
Authors: Maneemai Ongart , Cujilan Alvarado Maira Cristina , Calderon Intriago Lina Graciela , Donoso Triviño Alicia Jeanette , Franco Coffré Joicy Anabel , Pratico Domenico , Schwartz Kristof , Tesfaye Tadele , Yamasaki Takao
Published: February 2024

Sensory processing is a crucial function of the nervous system that significantly affects a large portion of the population, particularly older individuals who may be dealing with different forms of dementia. The global population of people aged 65 or older has reached a substantial count of around 703 million, representing approximately 9% of the total global population. Within this demographic, an estimated 5-8% of those aged 60, highlighting the growing need to address sensory modulation challenges for healthy aging. Sensory diet, derived from sensory integration theory, provide a tailored approach to modulating sensory experiences and triggering neuroplastic changes in the brain. Recent neuroimaging studies have revealed intricate structural and functional alterations in the brain associated with the implementation of sensory diets. Furthermore, the integration of the Metaverse, augmented reality, and virtual reality has opened up personalized experiences, fostering cognitive stimulation and emotional well-being for individuals during aging. This article offers a comprehensive exploration of the effectiveness of sensory diets in enhancing attentional control, self-regulation, and alleviating sensory-related distress among the healthy aging and dementia population. By employing precise quantitative evaluations such as sensory processing scales and advanced neuroimaging methodologies, it presents solid evidence of the tangible impact of these interventions. Emphasizing the importance of interdisciplinary cooperation and leveraging technological advancements, the article underscores the crucial need for customized sensory diets to optimize sensory processing and improve the overall well-being of older individuals contending with sensory modulation challenges and dementia.
Survival and Neurological Outcomes Following Corpectomy for Spinal Metastatic Disease: A Single Institutional Experience
Authors: Chowdhury AJ , Teferi Nahom , Lee Sarah J , Vivanco-Suarez Juan , Chenoweth David , Littlefield Connor P , Petronek Michael , Buatti John M , Noeller Jennifer , Hitchon Patrick W
Published: February 2024

Background: The incidence of spinal metastatic disease has risen with improved cancer survivorship. Separation surgery, the current standard surgical treatment, does not fully address spinal deformity. Advances in operative management warrant reevaluating maximal tumor resection and anterior column reconstruction with corpectomy.
Methods: An IRB-approved retrospective single-center review of 63 patients was performed. Demographics, tumor characteristics, clinical and radiographic data, treatments, and neurological and survival outcomes were analyzed.
Results: The mean age at presentation was 63.5 ± 9.6 years (range, 37-84 years) and 28 patients (44.4%) were female. Functional outcomes, measured by KPS, RAND-36 survey scores and Oswestry Disability Index all improved postoperatively (pre- vs postop: 70 to 80 (p=0.0056), 26.5 to 46.4 (p=0.0081), and 28.9 to 16.9 (p=0.0613), respectively). Spinal alignment also improved, with Cobb angle measurements showing a reduction in spinal kyphosis from -5 to 0 (p=0.021). Nine patients (14.5%) had non-fatal postoperative complications. The median OS for this cohort was 14.4 months (range, 0.6-145.0 months) with median follow-up time of 15.5 months.
Conclusion: In oligometastatic spinal disease patients with good functional status, corpectomy for decompression of neural elements, deformity correction, and spinal stabilization is associated with improvements in pain and functional outcomes without overwhelming morbidity.
The Overview of the Possible Exposure of Infants to Microplastics
Authors: Mišľanová Csilla , Valachovičová Martina , Slezáková Zuzana
Published: February 2024

Microplastics are small plastic pieces with sizes less than 5 mm. They are becoming a global concern due to the potential risk to human health. The potential risks of microplastics may be greater for infants because they do not have sufficiently developed metabolizing enzymes, have a lower ability to remove them, high sensitivity of target organs. Infants should be breastfed for the first six months of life. Breast milk is considered to be the most complete and suitable source of nutrition. However, if breastfeeding during this period is not possible, it is necessary to use formulas designed for infant initial feeding. Infants may be exposed to higher levels of MPs through infant foods or plastics products. The aim of this study is to describe the possible sources of exposure to microplastics such as human placenta, plastic feeding bottles, toys as well as the presence of released microplastics in infants feces, breast milk and infant formulas. There is still not enough data available from the studied area. Therefore, it is necessary to pay increased attention to minimizing the negative effects of microplastics on human health.
Qualtra Geothermal Power Plant: Life Cycle, Exergo-Economic and Exergo-Environmental Preliminary Assessment
Authors: Zuffi Claudio , Ungar Pietro , Fiaschi Daniele , Giampaolo Manfrida , Batini Fausto
Published: February 2024

Qualtra, an innovative 10 MW geothermal power plant proposal, employs a closed-loop design to mitigate emissions, ensuring no direct release into the atmosphere. A thorough assessment utilizing energy and exergy analysis, Life Cycle Assessment (LCA), Exergo-economic and Exergo Environmental Analysis (EevA) was conducted.
The LCA results, utilizing the ReCiPe 2016 midpoint methodology, encompass all the spectrum of environmental indicators provided. The technology implemented makes it possible to totally avoid direct atmospheric emissions from the Qualtra plant, so the environmental impact is mainly due to indirect emissions over the life cycle.
The results obtained for the Global Warming Potential indicator is about 6.6 g CO2/kWh, notably lower compared to other conventional systems. Contribution analysis reveals that the construction phase dominates, accounting for over 90% of the impact in all LCA MidPoint categories.
At the component level, a single score calculation incorporating normalization and weighting was executed. The resulting single score is then used into Exergo-Environmental Analysis (EEvA), highlighting the well system as the most impactful contributor, constituting approximately 45% of the total impact. Other substantial contributions to the environmental impact include the condenser (21%), the turbine (17%), and the HEGeo (14%). The Exergo-Economic analysis assesses cost distribution across major plant components, projecting an electricity cost of about 8.3 c€/kWh.
On the Origin of Evergreen Broad-Leaved Forest in Eastern Asia from the Evidence of Floristic Elements
Authors: Hua Zhu , Yunhong Tan
Published: February 2024

The arguments on the origin and evolution of the evergreen broad-leaved forest in eastern Asia, especially in the evolutionary process, exist generally, even contrary in some cases. The origin and evolution of the flora of eastern Asia, the formation time of Asian monsoon, and the implications from phylogenetic and molecular biogeographic studies in some important taxa, as well as in palaeobotanical evidences, are debatable. Most researches from different disciplines suggested that the monsoon in Miocene is a key to diversification of eastern Asian flora and its evergreen broad-leaved forest. The common view is that the evergreen broad-leaved forest of East Asia is closely related to the monsoon intensity and developments, which are caused by the uplift of Himalaya-Tibet, during or after the mid-Miocene. The analysis on the floristic elements show that the present subtropical evergreen broad-leaved forest in eastern Asia could have an early or ancient tropical origin and a tropical Asian affinity, but their species are dominated by the Chinese endemic or eastern Asian distribution, many of which are the tropical sister ones. The time of Himalayan uplift and intensity of monsoon climate is believed the key for the formation of the evergreen broad-leaved forest in eastern Asia. Combined existing palaeobotanical findings, the uplift of Himalayas and the formation of monsoon climate, as well as floristic elements of the subtropical evergreen broad-leaved forest, we believe that it was evolved from a Asian tropical rain forest after mid-Miocene in southeastern region of eastern Asia, while the ancient subtropical evergreen broad-leaved forests in southwestern region continuously evolved into the present subtropical ones.
Amphiphilic Graft Copolymers as Templates for the Generation of Binary Metal Oxide Mesoporous Interfacial Layers for Solid State Photovoltaic Cells
Authors: Lim Seung Man , Jeong Hayeon , Moon Juyoung , Park Jung Tae
Published: February 2024

The binary metal oxide mesoporous interfacial layers (bi-MO meso IF layer) templated by a graft copolymer is synthesized between a fluorine-doped tin oxide (FTO) substrate and nanocrystalline TiO2 (nc-TiO2). Amphiphilic graft copolymers, Poly(epichlorohydrin)-graft-poly(styrene), PECH-g-PS, was used as a structure-directing agent, and the fabricated bi-MO meso IF layer exhibits good interconnectivity and high porosity. Even if the amount of ZnO in bi-MO meso IF layer increased, it was confirmed that the morphology and porosity of bi-MO meso IF layer was well maintained. In addtion, bi-MO meso IF layer coated onto FTO substrates show higher transmittance compared with a pristine FTO substrate and dense-TiO2/FTO, due to the reduced surface roughness of FTO. The overall conversion efficiency (η) of a solid state photovoltaic cells, dye-sensitized solar cell (DSSC) fabricated with nc-TiO2 layer/bi-MO meso IF layer TZ1 used as a photoanode reaches 5.0% at 100 mW cm-2, which is higher than that of DSSC with a nc-TiO2 layer/dense-TiO2 layer (4.2%), resulting from enhanced light harvesting, good interconnectivity, and reduced interfacial resistance. The cell efficiency of the device did not change after 15 days, indicating that the bi-MO meso IF layer with solid-state electrolyte has improved electrode/electrolyte interface and electrochemical stability. Additionally, commercial scattering layer/nc-TiO2 layer/bi-MO meso IF layer TZ1 photoanode fabricated solid state photovoltaic cells (DSSC) achieved an overall conversion efficiency (η) of 6.4% at 100 mW cm-2.
Constructing a Model to Understand the Current Behavior of Tourists in Consuming Local Culinary at the Destination
Authors: Wachyuni Suci Sandi , Priyambodo Tri Kuntoro , Sulistyadi Yohanes , Entas Derinta , Murhadi Murhadi , Wiweka Kadek
Published: February 2024

To enhance local culinary offerings, it is imperative to comprehend visitor behavior prior to, during, and subsequent to their visit. This study utilizes a quantitative methodology. The sample for this study consisted of 482 tourists who indulged in traditional cuisine in Yogyakarta and Solo. Data was collected between February and March 2021 through the distribution of Google forms both directly and online via WhatsApp broadcast messages. The quantitative data analysis technique employed utilizes descriptive statistics and structural equation modeling (SEM). The variables investigated in this study demonstrate a favorable impact on consumer buying choices, with intrinsic variables (individual, motivational, and gastronomic experience) accounting for 52.5% or greater than extrinsic variables (social media and socio-cultural influences), which account for 41.4%. The behavior model is structured into three sequential stages: pre-consumption, consumption, and post-consumption. Tourists place experience as their foremost incentive for engaging in local cuisine excursions. This research has theoretical implications in terms of the uniqueness of visitor consumer behavior theory, specifically in the context of local culinary tourism. The behavior model undergoes a transformation into a comprehensive approach for assessing tourist behavior. The practical implications of this research can be utilized by many stakeholders, such as destination managers and the government, to sustain local culinary tourism destinations. These implications are based on market factors and involve the incorporation of information technology.
Optimizing Productivity Indicators through the Implementation of Industry 4.0 Technologies
Authors: Soto Osornio Juan Emigdio , González Lorence Armida , Navarrete Damian Jaime , Morales Morales Cornelio , Ayala Landeros José Gabriel
Published: February 2024

Key performance indicators are essential for any company to enhance its competitiveness. How-ever, a common issue is the manual collection of production data using record sheets, which are later digitized on desktop computers and processed in Excel sheets. Shockingly, 41% of companies in Mexico have no plans for digitalization. This work aims to develop a Real-time Productivity Indicator Monitoring System using Industry 4.0 technologies for a medium-sized manufacturing firm specializing in die-cutting automotive parts. The Advanced Quality Planning methodology was applied to develop the Conceptual, Product, and Process Engineering and its validation. The experimental tests demonstrated a reliability level of 99.98%, which exceeded initial expectations. The primary contributions presented in this work are related to the development of algorithms, communication protocols, data analysis, and general optimization of the calculation process. The study's only limitation was the short experimentation time.
Pelvic Ring Fractures: A Biomechanical Comparison of Sacral and Lumbopelvic Fixation Techniques
Authors: Tripathi Sudharshan , Nishida Norihiro , Soehnlen Sophia , Kelkar Amey , Kumaran Yogesh , Seki Toshihiro , Sakai Takashi , Goel Vijay K.
Published: February 2024

Abstract
Background Context
Pelvic ring fractures are becoming more common in the aging population and can prove to be fatal, having mortality rates between 10% and 16%. Stabilization of these fractures is challenging and often require immediate internal fixation. Therefore, it is necessary to have a biomechanical understanding of the different fixation techniques for pelvic ring fractures.
Methods
A previously validated three-dimensional finite element model of the lumbar spine, pelvis, and femur was used for this study. A unilateral pelvic ring fracture was simulated by resecting the left side of the sacrum and pelvis. Five different fixation techniques were used to stabilize the fracture. A compressive follower load and pure moment was applied to compare different biomechanical parameters including range of motion (contralateral sacroiliac joint, L1-S1 segment, L5-S1 segment), and stresses (L5-S1 nucleus stresses, instrument stresses) between different fixation techniques.
Results
Transiliac -trans sacral screw fixation at S1 and S2 showed the highest stabilization for horizontal and vertical displacement at the sacral fracture site and reduction of contralateral sacroiliac joint for bending and flexion range of motion by 165% and 121%, respectively. DTSF (Double transiliac rod and screw fixation) model showed highest stabilization in horizontal displacement at the pubic rami fracture site, while the L5_PF_W_CC (L5-Ilium posterior screw fixation with cross connectors) and L5_PF_WO_CC ( L5-Ilium posterior screw fixation without cross connectors) showed higher rod stresses, reduced L1-S1 (approximately 28%), and L5-S1 (approximately 90%) range of motion.
Conclusions
Longer sacral screw fixations were superior in stabilizing sacral and contralateral sacroiliac joint range of motion. Lumbopelvic fixations displayed a higher degree of stabilization in the horizontal displacement compared to vertical displacement of pubic rami fracture, while also indicating the highest rod stresses. When determining the surgical approach for pelvic ring fractures, patient-specific factors should be accounted for to weigh the advantages and disadvantages for each technique.
Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases
Authors: Morshed Md Niaj. , Akter Reshmi , Mahmud Imran , Karim Md. Rezaul , Iqbal Safia , Islam Md. jakaria , Kang Se Chan , Yang Deok Chun
Published: February 2024

Rare ginsenoside compound K (CK), is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development as well as ginsenosides-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bio-conversion processes. Current research shows that CK has a wide range of pharmacological actions including boosting osteogenesis, lipid and glucose metabolism, lipid oxidation, insulin resistance, anti-inflammatory, and anti-apoptosis properties. Further research on the bioavailability and toxicology of CK can advance its medicinal application. The purpose of this review is to lay the groundwork for future clinical studies and the development of CK as a therapy for metabolic disorders. Furthermore, the toxicology and pharmacology of CK are investigated as well in this review. The findings indicate that CK primarily modulates signal-ing pathways associated with AMPK, SIRT1, PPARs, WNTs, and NF-kB. It also demonstrates a positive therapeutic effect of CK on nonalcoholic fatty liver disease, obesity, hyperlipidemia, diabetes, and its complications, as well as osteoporosis. Additionally, the analogues of CK showed more bioavailability, less toxicity, and more efficacy against disease states. Enhancing bioavailability and regulating hazardous variables are crucial for its use in clinical trials.
Baita Alit Berlayar Kala Pandemi
Authors: Astuti Cindy Cahyaning
Published: February 2024

Rasa syukur selalu tercurah kepada Allah SWT yang senantiasa melimpahkan rahmat, hidayah serta kesehatan, sehingga kami dapat melaksanakan program Kuliah Kerja Nyata Tangguh (KKN-Tangguh) Universitas Muhammadiyah Sidoarjo tahun 2020.Kuliah Kerja Nyata (KKN) adalah program yang ditempuh mahasiswa Universitas Muhammadiyah Sidoarjo merupakan perwujudan dari salah satu Catur Dharma Perguruan Tinggi, yaitu bermaksud memberikan pengalaman secara langsung baik fisik maupun mental kepada calonsarjana dengan terjun bersama masyarakat dengan menerapkan ilmu jurusan masing-masing.
Análisis bibliométrico del panorama actual de la producción científica mundial sobre el desarrollo de vacunas contra la caries dental (2011-2020)
Authors:   , Torres Loyola Alejandra Mercedes , Rojas Arana Carlos Adrian
Published: February 2024

Objetivo: El objetivo del presente estudio fue realizar un análisis bibliométrico de la investigación científica sobre el desarrollo de vacunas contra la caries dental. Métodos: Se realizó una extracción de la producción científica publicada sobre el desarrollo de vacunas contra la caries dental entre los años 2011 y 2020 de la base de datos Scopus . Se utilizó Microsoft Excel para la elaboración de tablas y Scival para el análisis de datos, los cuales se dividieron en indicadores de producción, impacto y colaboración. Se utilizó VOSviewer para el análisis de co-ocurrencia de las palabras clave y redes colaborativas. Resultados: Se recuperaron 106 estudios de la base de datos Scopus, que se realizaron sobre el desarrollo de vacunas contra la caries dental dentro de los años 2011-2020. La universidad de Wuhan, en China, fue la universidad con mayor producción científica sobre el tema, con 4 publicaciones, siendo el país donde se encuentra, el más productivo. Sobre las revistas más productivas, el primer lugar fue ocupado por Journal of Dental Research con 7 publicaciones. El mayor porcentaje de los documentos analizados se ubicaron en revistas de cuartil 1 y en el patrón de colaboración nacional. Conclusión: La mayoría de los manuscritos realizados respecto al desarrollo de vacunas contra la caries dental fueron publicados en China y en revistas del cuartil Q1. Además, se encontró que Yan Huimin, Yang Jingyi, Zhou Dihan, Yang Yi, Li Yuhong y Fan Mingwen encabezan la lista de autores más productivos. Asimismo, se identificó a Journal of Dental Research como la revista más productiva y citada.
Efecto del compostaje sobre la capacidad alelopática de hojarasca de Eucalyptus globulus var. compacta utilizando como indicador el cultivo de Lactuca sativa
Authors:   , Anaya Alonso Felix Andre
Published: February 2024

El objetivo principal de esta investigación consistió en evaluar la disminución de los compuestos aleloquímicos encontrados en la hojarasca de Eucalyptus globulus var. compacta por medio de compostaje, los compuestos aleloquímicos fueron en mayor proporción (según el laboratorio Slab) fenoles 27.55% y taninos 27.06%, la reducción de estos aleloquímicos se realizó por medio de diferentes compostajes combinados con estiércol bovino seco en diferentes relación Carbono/Nitrógeno (20, 25, 30 y 35) y en el control solo se utilizó estiércol. El estudio tuvo lugar en el distrito de San Isidro, Lima, Perú, al finalizar los 4 meses de compostaje se mandaron muestras al laboratorio Slab, donde se evidenciaron grandes diferencias en el porcentaje de aleloquímicos en el compostaje final comparado con el inicial; el tratamiento 3 (C/N 30) redujo exitosamente los taninos en un 92.7%, y fenoles en un 99.27%. Para evidenciar la eficacia de los compostajes producidos como aptos para cultivo, se utilizó a la Lactuca sativa como planta indicadora, teniendo 25 macetas (5 por tratamiento), cada maceta de 3 L con 2.5 kg de los compostajes y una lechuga. Después de 5 semanas de cultivo, se presenciaron diferencias significativas (p<0.05) en las variables de los tratamientos de Lactuca sativa a excepción de la variable porcentaje de germinación la cual no presentó diferencias significativas (p<0.05). El tratamiento con la mayor media de área foliar (1037.40cm2), peso fresco (109.16gr) y peso seco (12.34gr), fue el tratamiento 3 (C/N 30). Se empleó la media aritmética de las mediciones como indicador para las pruebas estadísticas. Como resultado del estudio, se determina que los tratamientos de compostaje de hojarasca alelopática de la variedad E. globulus var. compacta lograron el mayor éxito en la reducción…
Factores asociados a la infección por Covid-19 y a los costos por ausentismo laboral en trabajadores administrativos de una entidad mixta, Perú, 2021
Authors:   , Guzman Cuzcano de Cersso Jessica Catherine
Published: February 2024

OBJETIVO: Identificar factores asociados a COVID-19 y a los costos por ausentismo laboral en trabajadores administrativos de una entidad mixta de Lima. METODOLOGÍA: Estudio transversal analítico que incluyó trabajadores con síntomas respiratorios y contactos entre enero a diciembre del 2021 de una entidad financiera. Se consideró COVID-19 confirmado si tenía prueba molecular o antigénica positiva. Asimismo, se determinó la tasa global de ausentismo (TGA) como la división entre los días faltados con el total de días laborales. Se calcularon los costos relacionados al ausentismo según la metodología Heinrich. Los factores asociados se determinaron por chi cuadrado para categóricas. Para numéricas, T de Student o Kruskall Wallis según normalidad de las variables. RESULTADOS: Se incluyó 210 trabajadores con una edad media de 35,8 años, un 54,8% fueron mujeres y sólo un 18,1% tenían alguna comorbilidad. Un 54,8% presentó COVID-19 confirmada, hubo una TGA de 5,4% del total de días trabajados y el costo directo laboral fue $68,578.19. El COVID-19 confirmado se asoció a trabajo presencial y tener más de una comorbilidad. La tasa de ausentismo también al número de comorbilidades y a presentar COVID confirmado. Los costos relacionados a ausentismo, se asociaron a presentar COVID confirmado, mayor edad, mayor índice de masa corporal, más de una comorbilidad, trabajo remoto y a cargos gerenciales. CONCLUSIONES: El número de comorbilidades fue el factor común para presentar COVID-19 confirmado, ausentismo y sus costos laborales relacionados. El trabajo presencial presentó asociación con COVID confirmado y por tanto a mayor costo. Finalmente, presentar mayor edad, mayor índice de masa corporal y cargos gerenciales sólo se asociaron a mayores costos laborales.
The origin, inter-subspecies hybridization and adaptation of house mice (Mus musculus)
Authors: Huang Ling , Jing Meidong , Chen Yingjie , Yuan Wenbo , Song Ying , Bi Xiaoxin
Published: February 2024

The origin, inter-subspecies hybridization and genomic basis of adaptation of house mice (Mus musculus) were not well-resolved. Population genomic analyses with 349 samples from Eurasia confirmed the Pakistan-Himalaya-India junctional region as the origin centre. The divergence of Mus musculus domesticus, M. m. musculus and M. m. castaneus occurred during different interglacial stages beginning ~350 thousand years ago. Long-distance introgression from musculus into castaneus and from castaneus into musculus occurred in southern and northern China, respectively. Genomic introgression in hybrids from Europe and East Asia revealed that genomic differentiation, recombination rate, and biological functions of genes determined the introgression capability of distinct genomic regions. Unidirectional introgression of the Y chromosome made all wild mice in East Asia holding the musculus-type Y chromosome. Analyses on selective sweeps in the three subspecies elucidate the genomic basis of adaptation during spread. Our data provide novel insights into the origin and evolution of house mice.
Capturing Formulation Design of Battery Electrolytes with Chemical Large Language Model
Authors: Soares Eduardo , Sharma Vidushi , Brazil Emilio Vital , Na Young-Hye , Cerqueira Renato
Published: February 2024

Recent progress in large transformers-based foundation models have demonstrated impressive capabilities in mastering complex chemical language representations. These models show promise in learning task-agnostic chemical language representations through a two-step process: pre-training on extensive unlabeled corpora and fine-tuning on specific downstream tasks. By utilizing self-supervised learning capabilities, foundation models have significantly reduced the reliance on labeled data and task-specific features, streamlining data acquisition and pushing the boundaries of chemical language representation. However, their practical implementation in further downstream tasks is still in its early stages and largely limited to sequencing problems. The proposed multimodal approach using MoLFormer, a chemical large language model, aims to demonstrate the capabilities of transformer based models to non-sequencing applications such as capturing design space of liquid formulations. Multimodal MoLFormer utilizes the extensive chemical information learned in pre-training from unlabeled corpora for predicting performance of battery electrolytes and showcases superior performance compared to state-of-the-art algorithms. The potential of foundation models in designing mixed material systems such as liquid formulations presents a groundbreaking opportunity to accelerate the discovery and optimization of new materials and formulations across various industries.
Characterization of phosphate modified red mud based composite materials and study on heavy metal adsorption
Authors: Jin Wenlou , Yang Yanzhi , Jin Jiacheng , Xu Mingchen , Zhang Zhipeng , Dong Fan , Shao Min , Wan Yushan
Published: February 2024

In this paper, Bayer red mud (RM) and lotus leaf powder (LL) were used as the main materials, and KH2PO4 was added to modify the material. Under the condition of high temperature carbonization, RMLL was prepared and phosphate modified red mud matrix composite (PRMLL) was prepared based on KH2PO4 modification, which can effectively remove Pb2+ from water. The optimum preparation and application conditions were obtained by orthogonal experiment: dosage 0.1g, ratio 1:1 and temperature 600℃. The effects of PH, dosage and initial concentration on the adsorption of Pb2+ were studied. The pseudo-first-order, pseudo-second-order and Elovich kinetic models were fitted to the experimental data, and it was found that RMLL and PRMLL were more consistent with the pseudo-second-order kinetic model and chemisorption. Langmuir, Freundlich, Timkin and Dubinin-Radushkevich isothermal adsorption models were used to fit the experimental data, and it was found that RMLL and PRMLL were more consistent with Langmuir model. In addition, the maximum adsorption capacity of RMLL and PRMLL was 188.1mg/g and 213.4mg/g respectively. Are larger than the adsorption capacity of their monomers. Therefore, the use of RMLL and PRMLL as the removal of Pb2+ from water is a potential application material.
Modulation of human induced neural stem cell-derived dopaminergic neurons by DREADD reveals therapeutic effects on a mouse model of Parkinson’s disease
Authors: Wang Xueyao , Han Deqiang , Zheng Tianqi , Chen Zhiguo
Published: February 2024

Background
Stem cell-based therapy is a promising strategy for treating Parkinson’s disease (PD) characterized by the loss of dopaminergic neurons. Recently, induced neural stem cell-derived dopaminergic precursor cells (iNSC-DAPs) have been emerged as a promising candidate for PD cell therapy because of a lower tumor-formation ability. Designer receptors exclusively activated by designer drugs (DREADDs) are useful tools for examining functional synaptic connections with host neurons.
Methods
DREADD knock-in human iNSCs to express excitatory hM3Dq and inhibitory hM4Di receptors were engineered by CRISPR. The knock-in iNSCs were differentiated into midbrain dopaminergic precursor cells (DAPs) and transplanted into PD mice. The various behavior test such as the Apomorphine-induced rotation test, Cylinder test, Rotarod test, and Open field test were assessed at 4, 8, or 12 weeks post-transplantation with or without the administration of CNO. Electrophysiology were performed to assess the integrated condition and modulatory function to host neurons.
Results
DREADD expressing iNSC was constructed with normal neural stem cell characteristics, proliferation ability, and differentiation potential into dopaminergic neuorns. DAPs derived from DREADD expressing iNSC showed matched function upon administration of clozapine N-oxide (CNO) in vitro. The results of electrophysiology and behavioral tests of transplanted PD mouse models revealed that the grafts established synaptic connections with downstream host neurons and exhibited excitatory or inhibitory modulation in response to CNO in vivo.
Conclusion
iNSC-DAPs are a promising candidate for cell replacement therapy for Parkinson’s disease. Remote DREADD-dependent activation of iNSC-DAP neurons significantly enhanced the beneficial effects on transplanted mice with Parkinson’s disease.
No impact of time from diagnosis to treatment on survival in newly diagnosed AML treated with venetoclax-based regimens
Authors: Baden David , Zukunft Sven , Hernández Gema , Wolgast Nadine , Steinhäuser Sophie , Pohlmann Alexander , Schliemann Christoph , Mikesch Jan-Henrik , Steffen Björn , Sauer Tim , Hanoun Maher , Schäfer-Eckart Kerstin , Krause Stefan , Hänel Mathias , Einsele Hermann , Jost Edgar , Brümmendorf Tim , Scholl Sebastian , Hochhaus Andreas , Neubauer Andreas , Burchert Andreas , Kaufmann Martin , Niemann Dirk , Schaich Markus , Blau Wolfgang , Kiani Alexander , Görner Martin , Kaiser Ulrich , Kullmer Johannes , Weber Thomas , Berdel Wolfgang , Ehninger Gerhard , Müller-Tidow Carsten , Platzbecker Uwe , Serve Hubert , Bornhauser Martin , Röllig Christoph , Baldus Claudia , Fransecky Lars
Published: February 2024

In newly diagnosed acute myeloid leukemia, immediate initiation of treatment is standard of care. However, deferral of antileukemic therapy may be indicated to assess comorbidities or pre-therapeutic risk factors. We explored the impact of time from diagnosis to treatment on outcomes in newly diagnosed acute myeloid leukemia undergoing venetoclax-based therapy in two distinct cohorts.
By querying the Study Alliance Leukemia database and the health network TriNetX, we identified 138 and 717 patients respectively with an average age of 76 and 72 years who received venetoclax-based first-line therapy. When comparing patients who started treatment earlier or later than 10 days after initial diagnosis, no significant difference in median overall survival was observed - neither in the SAL cohort (7.7 vs. 9.6 months, p=.42) nor in the TriNetX cohort (7.5 vs. 7.2 months, p=.41). Similarly, severe infections, bleeding, and thromboembolic events were equally observed between early and later treatments, both in the overall patient groups and specific subgroups (age ≥75 years or leukocytes ≥20/nl).
This retrospective analysis indicates that delaying the start of venetoclax-based therapy in newly diagnosed acute myeloid leukemia might be a safe option for selected patients, provided that close clinical monitoring is performed.
Study on Three-Dimensional Geological Sweet Spot Evaluation of Tight Sandstone Reservoirs Based on Well Logging Data
Authors: Xiao Hui , Zhang Lei , Liu Junchen , Xiang Jiuzhou , Wang Chunbing , Zhang Han
Published: February 2024

Tight sandstone oil and gas resources have emerged as a crucial element in the future energy landscape. The primary focus of geological evaluation for the development of tight sandstone reservoirs involves the comprehensive assessment and selection of oil layers with high potential, commonly referred to as 'sweet spots.' This study proposes a geological sweet spot evaluation model for tight sandstone reservoirs, which utilizes eight conventional well logging curve data as samples: crosswave time difference, compressional wave time difference, natural gamma, density, wellbore diameter, phase resistivity, amplitude resistivity, and average neutron porosity. The model applies factor analysis and normalization principles to quantitatively assess the vertical distribution of geological sweet spots within the reservoir. Validation of the model is conducted using exemplar wells. Additionally, the study integrates seismic data with well logging data and employs waveform indication simulation techniques to simulate the stratigraphic parameters of the reservoir. This approach facilitates the establishment of a three-dimensional geological sweet spot evaluation model, enabling the inversion of key parameters of geological sweet spots in the target stratum. Consequently, the model allows for a quantitative assessment of the lateral distribution of geological sweet spots in Block DF11-2.
Comparison of ex vivo periodontal defects with their respective 3D models generated by artificial intelligence on CBCT images
Authors: Gerhardt Maurício do Nascimento , Bittencourt Hélio Radke , Rockenbach Maria Ivete Bolzan
Published: February 2024

Objectives
To evaluate the correlation of measures of periodontal defects in 3D models segmented by an AI-driven tool with the actual defects in dry skulls and mandibles and to verify the influence of arch, presence of metal artifact (dental fillings/metal posts), type of defect and dental implant artifact on the measures.
Material and Methods
45 periodontal defects were measured with a digital caliper and periodontal probe in three human dried skulls and five mandibles. These skulls and mandibles were scanned with a Cone-Beam Computed Tomography (CBCT) device and their digital files followed automated segmentation by an AI-driven tool (Patient Creator, Relu BV, Leuven, Belgium). The same periodontal defects were measured on the digital model generated by the AI-tool. Correlations of the measuring methods were assessed by means of Intraclass Correlation Coefficient and the influence of arch, presence of artifact and type of defects on the differences were assessed by Student’s t-test.
Results
The intraclass correlations ranged from moderate to excellent values. None of the studied factors (arch, dental fillings/metal posts and type of defect) played a role on the differences between actual and digital defects (P > 0.05). Three-wall defects presented significant influence of dental implant artifact on the measures of height (P = 0.002).
Conclusions
3D models generated by the AI-driven tool presented periodontal defects with linear measures ranging from moderate to excellent correlations with the actual measures.