bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparison of ratio of patient’s height to thyromental distance with modified mallampati test and upper lip bite test for prediction of difficult laryngoscopy
Authors: Gauchan Sabin , Thapa Chitra , Acharya Sulav , Dangol Sanam
Published: December 2023

Various airway evaluation tests are performed to predict difficult intubation. The ratio of Height to thyromental distance has been reported to have a good predictability. This study tested the performance of ratio of height to thyromental distance and compared it with commonly performed airway evaluation tests: the modified Mallampati test and upper lip bite test. This descriptive study was conducted in 120 patients presenting for surgery under general anesthesia with endotracheal intubation. Preoperative airway assessment was done using Modified Mallampati test, upper lip bite test and ratio of height to thyromental distance. The Cormack and Lehane grading was done during laryngoscopy to determine easy or difficult visualization of larynx. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of three tests were calculated. Difficult laryngoscopy was seen in 9 patients (7.5%). The sensitivity, specificity, positive predictive value, negative predictive value respectively for the tests were modified Mallampati test (22.2%, 89.2%, 14.3% and 93.4%), upper lip bite test (22.2%, 100%, 100% and 94.1%), ratio of height to thyromental distance (77.8%, 95.5%, 58.3% and 94.16%). In conclusion, we found that the ratio of patient’s height to thyromental distance performed better than MMT and ULBT in predicting difficult visualization of larynx in our population.
Prevalence of root caries and associated factors among elderly population visiting a dental teaching hospital in Kathmandu, Nepal
Authors: Joshi Rojin , Gautam Suman , Joshi Barsha
Published: December 2023

Among the oral ailments which are observed by dental practitioners in elderly, root caries is a significant one. It has been reported that about a third of older population bears most of the root caries burden. Root surface caries is one of the significant oral health problems in the elderly, and the incidence of root surface caries has been found to be one of the major risk factors for tooth loss. Limited studies have been carried out on root caries in elderly patients in context of Nepal. Hence, the objective of this study was to find the prevalence of root caries and its associated factors among the elderly population. This observational cross sectional study was done on 188 adult patients of 60 years and above. A specifically designed questionnaire was used to collect the following information: socio-demographic characteristics, use of medication, oral hygiene practices and oral health behaviour. Data were analyzed using Chi square test and descriptive statistics were calculated. It was found that the prevalence of root caries was 61.7% and it increased with age. There was an association between root caries and socioeconomic status which showed root caries was seen more in adults of upper middle class. More of root caries was seen in females, those who were unmarried, taking medications and non vegetarians. Oral hygiene habits and oral health behaviour had a positive impact on root caries. More of root caries was seen on buccal surface of molars.
Penerapan Zahir Accounting Versi 6 Untuk Pengolahan Data Akuntansi Pada Toko Kenanga
Authors: Fauziah Nur Shiami Natasya
Published: December 2023

Toko Kenanga merupakan perusahaan dagang yang bergerak di bidang pakaian, yang menjual perlengkapan sekolah, dalam pencatatan data keuangan pada Toko Kenanga masih di lakukan secara manual. Pengolahan akuntansi secara manual memiliki risiko yang lebih besar dibandingkan dengan menggunakan sistem yang sudah terkomputerisasi, hal ini berdampak pada ketidaksesuaian laporan keuangan, pencatatan transaksi dan alat hitung yang masih manual, sehingga dalam pengerjaannya kurang efektif dan efisien, begitu juga dengan bukti transaksi yang menumpuk dan memungkinkan mudah hilang ataupun rusak. Zahir Accounting menghasilkan laporan keuangan yang akurat, mudah dipahami, fleksibel dan tepat waktu, baik dari dalam perusahaan maupun dari luar perusahaan.  Metode penelitian yang digunakan yaitu metode pengumpulan data yang terdiri dari wawancara, observasi, dan studi pustaka. Dengan adanya sistem pengolahan data secara terkomputerisasi dapat meminimalisir terjadinya kesalahan dalam pengolahan data yang berhubungan dengan toko, agar dalam pencatatan laporan keuangan lebih mudah, praktis, dan akurat. Adapun metode pengolahan data menerapkan aplikasi program akuntansi yaitu Zahir Accounting Versi 6. Dengan adanya penerapan aplikasi ini diharapkan dapat mendukung jalannya suatu sistem agar dapat terolah secara efisien sehingga diperoleh hasil yang lebih baik terutama pada laporan keuangan.
Management of Ischemic Priapism in a 14 Year Old Patient
Authors: ŞİMŞEK Alper , BÜTÜN Salih , DURAN Mesut Berkan , KÜÇÜKER Kürşat , ÇELEN Sinan , ÖZLÜLERDEN Yusuf
Published: December 2023

Introduction: Priapism can occur in all age groups, including neonatales, children and adolescents. Pediatric priapism treatment is similar to adult priapism treatment, but there are no guidelines for the management of priapism, which is not common in children.

Case presentation: We present a pediatric low-flow priapism case who was unresponsive to conservative methods and underwent T-shunt operation

Conclusions: In the present case, we wanted to emphasize when distal shunt surgery, which is rarely performed in pediatric patients, is necessary and how it is managed.
Development of physical qualities of teenage freestyle wrestlers
Authors: Danko Grigory , Danko Taras , Heretic Anatoly , Krupenya Svitlana , Zhivolovych S.
Published: December 2023

This article deals with issues aimed at the development of free wrestling in the adolescent period of child development. One of the most difficult, it is not for nothing that it is called "transitional" and "turning point", "difficult" or even "critical". These names fully reflect the complexity and importance of the processes taking place in this age period. The transition from childhood to adulthood is the main content of this period. At this age, qualitatively striking changes occur, mental and physical elements of growing up appear. Hormonal restructuring of the body leads to changes in self- awareness, communication with adults and peers, changes in ways of communicating with the surrounding world, emergence of new interests. A new look at the content of moral and ethical norms that shape behavior, activity and communication with others is emerging.

A distinctive feature of the development of modern freestyle wrestling is the growth of athleticism and general physical training of athletes. The main condition for the high efficiency of physical training of wrestlers in the adolescent period is a strict accounting of the age and individual anatomical and physiological characteristics of athletes and individual stages of adolescent development, characteristic of this period.

Sports training, as a separate type of physical training, is a specially organized and consciously managed pedagogical process, the purpose of which is to improve or maintain at the required level basic and special developed physical qualities, various motor skills and abilities, high functional capabilities of human organs and systems, as well as knowledge related to them.

General physical training is a process of harmonious development of the main physical qualities that have a positive effect on achieving results in a specific sport and the effectiveness of building the training process as a whole.
Dynamics of indicators of cadets’ physical and psycho-emotional state in the process of engagement in sports games
Authors: Zimnikov O.O. , Yahodzinskyi V. P. , Nikitin A. M. , Kostushko I. A. , Stoyanov R. V. , Sydorchuk V. V. , Romanchenko D. Yu. , Stasiuk V. M. , Kozlov S. V.
Published: December 2023

The aim of the article is to investigate the impact of sports games (football) on indicators of cadets’ physical and psycho-emotional state during their studying at a higher military educational institution (HMEI). The research was conducted at the Military Institute of Tank Troops of the National Technical University “Kharkiv Polytechnic Institute” (Kharkiv) in 2022-2023. 85 male cadets who studied in the third year took part in the research. Two groups were formed: the experimental group (EG, n=42), whose cadets played football during sports and mass work (SMW), and the control group (CG, n=43), whose cadets practiced according to the traditional method of SMW. The number of hours for physical training per week for EG and CG cadets was the same. The physical state of the cadets was assessed by such indexes as body mass, vital, strength, Robinson, heart rate recovery time after a standard load. The psycho-emotional state of the cadets was assessed using the WAM methodology (well-being, activity, mood). At the end of the experiment, better indicators of physical state were found in EG compared to CG. At the same time, while studying at the HMEI, the improvement of all studied indicators is more pronounced in the EG than in the CG. The best level of psycho-emotional state in cadets of both groups was found at the end of the experiment, however, it was better in EG than in CG. It was established that sports games, in particular football, during military training had a positive effect on the physical and psycho-emotional state of cadets, and also contributed to the cohesion of military units. Significant changes were found in the indicators of the cardiovascular and respiratory systems of the EG cadets. A high level of indicators of cadets’ physical and psycho-emotional state will contribute to the improvement of their success in mastering academic disciplines during their studying at the HMEI, which will ensure the effectiveness of their professional and combat activities in the future.
General physical fitness of powerlifters as a basis for effective strength development
Authors: Kyrychenko Taras
Published: December 2023

The article, based on the analysis and synthesis of data from the source base and practical experience, identifies the main features of the general physical fitness of powerlifting athletes as the basis for effective strength development. The attention is focused on the issues related to the individualization of the training process and the management of the physical condition of athletes, the importance of various forms of manifestation of strength abilities. It is emphasized that the growth of sports achievements i s primarily due to the improvement of the methodology of strength development. It is noted that the level of strength development in powerlifters is one of the most urgent problems of the educational and training process in this sport, and the solution of this problem will significantly increase the effectiveness of sports training in powerlifting.

The most important physical quality to develop in the process of general physical training of powerlifters is strength. In general, "strength" is defined as the ability to overcome external resistance or to counteract it with the help of muscle effort. The following specific forms of strength are distinguished by the nature of the effort and the mode of muscle function: fast strength, maximum strength, power endurance, and explosive strength.

Muscular effort in the conditions of the training process of powerlifters can manifest itself in different ways: once or repeatedly, in cyclic or variable work with high or low resistance, at high speed or slowly, in a relaxed or tense state of muscles. An important physical quality that needs to be developed in the process of general physical training of powerlifters is endurance. Endurance is usually equated with the powerlifter's ability to perform muscle work (squats with a barbell, bench press, deadlift) for a long time during competitions without signs of significant fatigue.
Fitness program for correction of overweight in women
Authors: Sergienko Yuri , Krupenya Svitlana , Chaplygin Vasily , Ovdeichuk A.O.
Published: December 2023

The article discusses a fitness program for the correction of overweight in women of early adulthood. This problem is very relevant for women of early adulthood today. More and more people have problems with obesity and overweight. One of the leading methods of body weight correction is physical exercises, which, in addition to reducing excess weight, also contribute to the normalization of metabolism, restoration of the body's adaptation to physical activity; normalization of the functions of the cardiovascular and other body systems, these programs are fitness.

Fitness is one of the world's most popular health improvement systems, which allows us to meet the modern needs of different age groups who want to make their figure beautiful and their health strong. The modern fitness industry offers a wide variety of techniques, and these techniques allow to expand the range of effects of physical exercises on the body of those who exercise.

We have developed an experimental program, the essence of which is that, taking into account the initial data and individual characteristics of the body constitution of the course participants, physical activity and training volumes were constantly adjusted throughout the program, which gives participants the opportunity to properly approach the training process, learn the basic steps, movements, adapt to the load, try and choose training for their further development, and modern training programs used in the fitness facility help to achieve results in the most

To achieve an effective weight loss result, two components must be used: nutritional adjustments and certain fitness training methods. Proper nutrition is an integral part of this process. Dual work improves metabolism and thus metabolic processes in the body, which helps to accelerate the process of reducing body fat.

To achieve the goal and objectives, we initially formed two groups of 10 participants who were engaged in a sports club, all of whom were of the first age group, of whom 70% had problems with overweight.
Lament for Watermelon
Authors: Muhammad Shah Daniel
Published: December 2023

.
Laparoscopic Sentinel Lymph Node Mapping Using NIR Fluorescence with ICG in Early Endometrial Cancer: Experience at a Tertiary Care Oncology Centre
Authors: Bhati Priya , Gupta Saumya , Garg Monal , Puthenveettil Nitu , Nair Indu R , Rajanbabu Anupama
Published: December 2023

Objective: To determine the detection rates and location of sentinel nodes as well as to determine intraoperative and postoperative surgico-pathological outcomes in endometrial cancer patients who underwent laparoscopic staging with sentinel node biopsy using ICG dye. Materials and Methods: This retrospective study was conducted in a tertiary care oncology centre, Amrita Institute of medical sciences, Kochi from April 2021 to March 2023. All cases of biopsy proven early stage endometrial carcinoma that underwent laparoscopic staging with SLN mapping using the ICG dye were included. All histological types were included, as long as the disease was confined to the uterus, clinically and on MRI. Results: A total of 80 patients were found eligible for the study. Only the patients with apparent uterine confined disease on preoperative MRI were selected for sentinel mapping, 80 % of whom had IA disease on MRI, and 20 % had IB, 13.5 % were high grade histology.The overall SLN detection rate was 93.75%, and bilateral detection rate was 92.5 %. Most common location was external iliac in 40.8% cases. Only 1 patient was found to harbour nodal micro metastasis on ultrastaging. Final histopathology identified stage IA in 63 (78.75%) patients, IB in 14 (17.5%), Stage II in 2 (2.5%) and Stage IIIC1 in 1 (1.25%) patient. Conclusion: Laparoscopic staging with SLNB using ICG is a practicable approach for uterine limited disease on preoperative evaluation. It extends the benefits of minimally invasive surgery to these patients, while overcoming the limitations of prohibitive cost or availability of expensive robotic equipment.
Differences in Nasopharyngeal and Lung Histopathology in Wistar Rats (Rattus norvegicus) Given Inhaled Formaldehyde Exposure with Doses of 20, 30, and 40 ppm
Authors: Niti Wedayani Anak Agung Ayu , Qadar Punagi Abdul , Audrey Nova , Cangara Husni , Kawi Junior David Giffard , Yusuf Ricky Setiadi
Published: December 2023

Background: Formaldehyde is known as a chemical substance that may induce structural cell changes in several organs, especially the respiratory system. Different concentrations of exposure may result in different degrees of severity in histopathology. Method: Twenty male Wistar rats were divided into 4 groups. Inhalation of 10% formaldehyde exposure in 6 hours per day over 16 weeks was done. Nasopharyngeal and lung tissues were taken with hematoxylin-eosin (H&E) staining to see histopathology structural changes and degree of severity. Bivariate analysis was conducted to find the correlation coefficient. Results: This experimental study found that severe dysplasia is correlated with long exposure. A strong correlation is found between concentrations and dysplasia (r=0.682), and a moderate correlation between duration of exposure and dysplasia (r=0.488).Discussion: Dysplasia of nasopharyngeal and lung tissue are in line with exposure of formaldehyde in rats. Formaldehyde exposure with 10 ppm and 15 ppm may lead to structural cell changes such as vacuolar degeneration, cell necrosis, epithelial exfoliation, and erosion in nasal passage. Also, longer exposure increases the severity of dysplasia. Squamous metaplasia was found in 20 ppm of formaldehyde over 2 weeks of exposure, in the epithelial respiratory system. Conclusion: The severity of dysplasia in rats is in line with the duration and concentrations of formaldehyde exposure. Long exposure will increase the severity of dysplasia and, similarly, high concentration of formaldehyde exposure increases the severity of dysplasia.
Voided Urine Sample in the Diagnosis of Prostate Cancer in Patients with Serum PSA Ranging between 2.6 to 10 ng/mL
Authors: C. Ghagane Shridhar , Shadab Rangrez , Nerli R. B. , Rai Shreyas , Thakur Madhukar L. , Gomella Leonard
Published: December 2023

Introduction: Prostate cancer (PCa) cells are known to be shed into the prostatic urethra and thus can be collected through a voided urine sample. In this preliminary prospective study, we have assessed the feasibility of detecting cancer of the prostate using a voided urine sample and targeting the genomic VPAC receptors in patients with lower urinary tract symptoms and a serum PSA ranging between 2.6 to 10 ng/mL. Materials & Methods: Patients ≥40 years old, with lower urinary tract symptoms and serum prostate-specific antigen (PSA) ranging between 2.6 - 10 ng/mL formed the study group. The voided urine sample was collected from all these patients for biomarker testing. All patients underwent a standard 12-core prostate biopsy. The results of the histopathological studies were then compared to the results of the urine biomarker. Results: A total of 76 male subjects presented to our hospital with lower urinary tract symptoms and a serum PSA ≥ 2.6 and ≤ 10 ng/mL. The voided urine sample was positive for malignant cells in 24/25 (96%) patients with PCa. There was one case of a false negative in this group. Histopathological examination of the core biopsy specimens was positive for malignancy in 23 (92%) cases of PCa. Conclusions: Voided urine samples can be used to diagnose PCa by targeting the VPAC receptors that are expressed on malignant cells. This test is highly sensitive and serum PSA levels or Gleason’s score have no impact on the sensitivity of this test.
Correlation between Age at First Menarche and Breast Cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014
Authors: Zuraidah Endah , Agatha Nur Fitrianingsih Pujiano , Qanita Edwar Sarah , Irianti Handayani Supri
Published: December 2023

Background: Breast cancer is one of the most common cancer among Indonesian females. Many risk factors can increase the chance of developing breast cancer. Hormonal factor seems to play a role in many cases of breast cancer. The aim of this research is to determine the relationship between age at menarche and breast cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014.Methods: The retrospective research is using cross-sectional design study with random sampling technique. There are 98 samples. The samples were taken in Archive Unit of Anatomical Pathology of FMUI with a further investigation in Medical Record Unit and Medical Department of Surgery in Dr. Cipto Mangunkusumo National General Hospital Jakarta. The data were analyzed by using chi square test then Fisher test. Results: There is no statistically significant between age at menarche and breast cancer in Dr. Cipto Mangunkusumo National General Hospital Jakarta in 2010-2014 (p>0,05). The results of this study also indicate that the 40-49 year age group is the age group that has the highest number of breast cancer cases compared to other age groups. The age at first menstruation > 12 years was associated with the highest frequency of breast cancer cases in the study population. Conclusion: The age at first menstruation statistically did not significantly affect breast cancer incidence in Dr. Cipto Mangunkusumo Hospital Jakarta in 2010-2014. However, further research using different study designs and larger sample sizes required.
Ten Year Experience of Epidemiological Trends and Clinical Pattern of Vulvar Tumor
Authors: Paul Diptajit , Soni Abhishek , Chatterjee Sumit S , Chanda Abhirup , Kaushal Vivek , Chauhan Ashok
Published: December 2023

Objectives: Vulvar tumor is a relatively uncommon female genito-urinary tumor, occurs mainly in post-menopausal females. Incidence and patterns of vulvar tumor differ from nation to nation, depending upon multiple factors. The aim of this study was to evaluate epidemiological patterns and clinical profile of vulvar tumor in our institution retrospectively. Methods: This is a retrospective study done in a regional cancer centre of India over10-years period. Data of all vulvar tumor patients, regarding demographic profile and tumor characteristics were collected from record section and reviewed. These data were analysed to get an idea about clinic-epidemiological trends of vulvar malignancy. Results: Total 47-patients with biopsy proven vulvar malignancy were found. Mean age at presentation was 63.4 years. Majority of the patients belonged to rural origin, were post-menopausal and multiparous. Most of them had pruritus as typical presenting symptoms. Histopathologically, squamous cell carcinoma constituted the major bulk. Labia was the commonest site of presentation. Bilateralism was found in one-third among them, inguinal lymphadenopathy and extensive disease were found in five and four patients, respectively. Conclusions: The hallmark about the present article is that it was conducted in the only referral cancer institute of this state. Limited studies from different region of India have published local patients’ data on vulvar tumor. A nationwide collaboration in this regard will help to understand the exact burden of this relatively rare malignancy, epidemiological trends and risk factors as well as an idea about how to manage these patients.
Comparison of Different Dosimetric Indices for Volumetric Arc Modulated Treatment Planning Using 2 Different Treatment Planning Systems: A Feasibility Study for Total Body Irradiation
Authors: Kumari Reena , Yadav Budhi Singh , Kumar Pankaj
Published: December 2023

Objective: To compare two different treatment planning systems (TPSs) for plan quality and to check the feasibility of VMAT TBI on the Elekta linear accelerator ‘Versa HD’. Methods: Ten clinical VMAT TBI plans were replanned in Monaco TPS version 5 for retrospective dosimetric analysis and to check the feasibility of treatment delivery in Elekta Versa HD. A dose of 12 Gy in 6 fractions was prescribed to cover 95% PTV. The OARs were the lungs, kidneys, heart, liver, and brain. Dosimetric optimization and calculation were performed in Monaco TPS with a statistical uncertainty of 1%, 2 mm grid. The chosen criterion for plan evaluation and comparison was based on plan quality, dosimetric indices like conformity and homogeneity index, and OAR doses. The comparison of time for optimization, monitor units, and beam on time was also analyzed. Pre-treatment verification using Octavious phantom and gamma analysis using Low’s method with a dose difference of 3% and distance to agreement 3mm criteria was done. The dosimetry of 2 VMAT TBI plans were compared using Wilcoxon signed rank test. Result: The calculated average maximum and mean doses of the PTV were 14.3321Gy and 12.235Gy for eclipse; and 14.428Gy and 12.198Gy for the Monaco system, respectively. The planning time in Monaco was approx. 4.5–6hrs compared to 14–18hrs for Eclipse TPS. Statistically significant difference was observed between the results of 2 TPSs in terms of monitor units, mean doses to lungs, kidneys, heart, and liver and planning time (P < 0.05). However, calculated p values for HI, CI, and brain for both VMAT TBI plans were not statistically different. Conclusion: The study showed the feasibility of VMAT TBI for VERSA HD as it offers faster, better optimization in a single target compared to the Eclipse.
Evaluation of Response and Toxicity in Patients with Locally Advanced Rectal Cancer Treated with Neoadjuvant Chemoradiation
Authors: Shewalkar Balaji , Gite Arpit , Pant Punita , Patel Jitendra
Published: December 2023

Purpose: To study the response after neoadjuvant chemoradiation in patients with locally advanced rectal cancer with capecitabine 825 mg/m2 daily PO bid with radiation at a dose of 45Gy/20#/4 weeks, to study the clinical profile of different patients with locally advanced rectal cancer, and to assess the toxicity of patients treated with neoadjuvant chemoradiationtherapy. Materials and Methods: A prospective observational study was conducted in 60 patients with histopathologically proven locally advanced rectal carcinoma from October 2018 to April 2020 . Neoadjuvant chemoradiation was planned with capecitabine 825 mg/m2 PO bid with radiation at a dose of 45 Gy/20#/4 weeks. Radiological response was assessed 6 weeks after treatment completion, and surgery was planned according to the response. Results: Thirty-seven patients underwent definitive surgery. Pathological complete response was observed in one patient, near complete response in seven, partial response in 27, and poor or no response in two patients. Of 37 patients who have undergone surgery, 30% of patients received sphincter preserving surgery. Radiation-induced acute skin and lower gastrointestinal tract lesions were observed. Capecitabine-induced diarrhea, hematological toxicities, and a few patients with hand foot syndrome were observed. Conclusion: In locally advanced rectal cancer, preoperative radio-chemotherapy with capecitabine improves local control and reduces the risks of acute and late toxicity compared to postoperative radiochemotherapy. Thus, preoperative radiochemotherapy with capecitabine is safe and well tolerated in locally advanced rectal cancer, especially in tumors of the lower and middle rectum.
Knowledge, Attitudes, and Practices of Gynecologic Cancer Patients at Maharaj Nakorn Chiang Mai Hospital Toward COVID-19: A Cross-Sectional Survey
Authors: Chuenchitkultavorn Varisa , Suprasert Prapaporn , Phianpiset Rattiya
Published: December 2023

Background and Aim: During the Covid-19 pandemic, the knowledge, attitudes, and practices about COVID-19 infection in gynecologic cancer patients were still limited. This study aimed to explore these issues.Methods: Gynecologic cancer patients who attended our gynecologic oncology unit between February and June 2022 were invited to a cross-sectional survey using a WHO survey tool. Results: 363 patients participated with 20.9% undergoing treatment and receiving the COVID-19 vaccine significantly less than the surveillance participants (85.4% vs.57.9%, P < 0.01). Forty-eight participants developed a COVID-19 infection. The most common vaccine used for the two first doses was AstraZeneca. Regarding attitudes issues, most participants felt health literacy was obtained easily. They considered that they had a moderate probability to have severe symptoms of COVID-19 infection and almost all knew the proper behavior for prevention. The participant reported little stress and most trusted healthcare workers and family doctors. They agreed with lifting regular rules to control the COVID-19 pandemic. The other opinions that were significantly higher in participants who did not receive the vaccine versus those who received the vaccine, were as follows: “If everyone is vaccinated, no need for me to vaccinate”, “the stress made me not want to vaccinate”, “no need to vaccine due to rare disease” and “the vaccine is unsafe”. Conclusion: Gynecologic cancer patients who were under treatment received the COVID-19 vaccine less than those under surveillance. Most participants revealed a good attitude toward this pandemic. However, unvaccinated participants were concerned about the severe side effects of the vaccine.
Clinico-Epidemiological Presentation and Treatment Outcome of Peripheral T-Cell Lymphoma– Not Otherwise Specified (PTCL-NOS): A Single Institutional Experience
Authors: Roy Partha Sarathi , Mallik Sreya , Sarma Anupam , Hazarika Munlima , Reddy Raghavender , D Nithin Raj
Published: December 2023

Background: Peripheral T-Cell Lymphomas (PTCL) are aggressive malignant lymphoproliferative disorders that represent 10-15% of all non-Hodgkin’s lymphomas (NHL). PTCL- not otherwise specified (PTCL-NOS), comprises approximately 6% of all NHLs, which do not meet the criteria for other mature peripheral T-Cell lymphoma as defined in WHO classification. With limited long-term data evaluating the outcome of PTCL-NOS in the Indian population, we aimed to determine the clinico-epidemiological profile and treatment outcome of patients with PTCL-NOS in a cancer care center from North-East India. Material and Methods: A retrospective observational analysis was performed on the medical records of patients who were diagnosed with PTCL-NOS between January 2015 and December 2018 at Dr. B. Borooah Cancer Institute. Results: Our study evaluated fifty-three patients with PTCL-NOS with the mean age at presentation being 45.3 years (SD ± 16.3 years). The majority of the patients (77.3%) presented with advanced stage (III/IV) with bone marrow involvement in 35.8% of the patients. B-symptoms were present in 58.4% of the patients. Extra-nodal sites of involvement were seen in 64.1% of the patients. The anthracycline-based chemotherapy regimen was the most commonly used in the frontline setting in 71.6% of the patients. Radiation therapy (IFRT) was received by 26.4% of the patients. The overall response rate (ORR) to first-line chemotherapy was 94.3% with complete response (CR) achieved by 62.3% of patients. Twenty-nine (58%) patients had relapsed/ progressive disease. With a median follow-up duration of 38 months, the 3-year progression-free survival (PFS) rate and 3-year overall survival (OS) rate were 27.6% and 33.9% respectively. The median PFS was 22 ± 3.3 months and the median OS was 28 ± 7.1 months.Conclusion: PTCL-NOS is one of the aggressive subtypes of NHL with limited therapeutic options and poor outcomes. Proper treatment adherence and the availability of newer therapeutic options can further enhance the overall outcome.
Clinicopathological Evaluation of Gall-Bladder Lesions in Cholecystectomy Specimens with Special Emphasis to Incidentally Detected Cases of Gall-Bladder Carcinoma Along with Immunohistochemical Study of Cytokeratin 7 and Cytokeratin 20
Authors: Bora Kakoli , Saikia Chandan Jyoti
Published: December 2023

Introduction: Cholecystectomy specimens show wide clinicopathological spectrum varying from common non neoplastic diseases to rare neoplastic lesions and histopathological examination the gold standard for final diagnosis. Gall Bladder Cancers (GBCs) are rare and account for 0.5% to 1.09% of all gall bladder lesions. It is either clinically suspected or incidentally diagnosed following cholecystectomy. Methods: It was a Hospital based cross-sectional Study. All cases diagnosed clinically & radiologically and operated as cholecystitis were included in the study. Histopathological diagnosis of gallbladder lesions, age & sex distribution in different gallbladder pathology, association with gall stones, Pathological pT staging of malignant cases and CK7 & CK20 immunohistochemical findings in malignant cases were observed in this study. Results: A total 340 cases of gallbladder specimens were examined histopathologically and 12 cases of gallbladder carcinoma were diagnosed. The most common histopathological diagnosis was chronic cholecystitis (79.4%) followed by chronic cholecystitis with cholesterolosis (7.6%) and adenocarcinoma (3.5%). The most common age group for gallbladder lesions was 4th decade (26.2%). Age varies from 09 – 85 years with a mean age of 39.4 years. Overall females (83%) are more commonly affected than males (17%) with male: female ratio is 1:4.96. Gallstones were present in 89.1% among total cases, 83.3% in malignant cases. Incidentally detected gallbladder carcinoma was 1.17% and most common histopathological type was adenocarcinoma NOS with Pathological pT staging was pT1 & pT2 only i.e. early stage. CK7 positivity was found in 91.6% cases and CK20 was positive in 16.7% cases. Both CK7 & CK20 was positive in 16.7% and both CK7 & CK20 was negative in one case (8.33%). Conclusions: Although the most common gall bladder histopathology diagnosis is chronic cholecystitis, the possibility of any incidental malignancy needs to be ruled out by mandatory routine histopathological examination of all cholecystectomy specimens.
An Assessment of the Effectiveness of an Intervention to Quit Tobacco Use in Patients Seek Treatment from the Institute of Oral Health, Maharagama, Sri Lanka
Authors: Amarasinghe Hemantha , Ananda WFD , Hariachandra SKD , Subashani RADG , Wipularathna KS , Nadira ASF , Jayasinghe Ruwan D
Published: December 2023

Background: Tobacco is consumed in both smoked and smokeless forms. STEP Survey Sri Lanka 2015 showed that 29.4% males and 0.1% females were current smokers, Smokeless Tobacco (SLT) use was found in 26% of males and 5% of females. Dental setting could be considered as a suitable venue to provide brief health education message to persuade quit from tobacco. The aim of this study was to assess the effectiveness of brief intervention among tobacco users attending the Institute of Oral Health, Maharagama, Sri Lanka. Methods: Dental Surgeons provide routine care for the patients at the OPD and assess the use of tobacco at the beginning and help patients to quit tobacco which takes only 3-5 minutes. Method of intervention of this study is to provide brief messages to quit tobacco based on oral health effects due to tobacco use: staining teeth, status of periodontal health, halitosis, smoker’s keratosis, whiteness (burning) of the mucosa and palate and chewer’s mucosa. Tobacco quit rate and attempts were assessed through the telephone conversation in 3 months, 6 months intervals. Results: One hundred and twenty eighty subjects were recruited for the study, 45 (35%) failed to contact after 6 months interval which yielded the total sample of 83. Among 73 betel chewers, 46 (63%) subjects were completely quit the habit after 6 months. Eight out of 10 subjects who chew betel quid more than 5 quid per day quit. Among 22 smokers, 7 (32%) completely quit smoking with brief intervention at dental setting. Conclusion: Brief intervention at dental setting immensely helps to quit habit of daily betel chewers. This is an ongoing study relatively larger sample is needed for confirmation of the findings.
Diagnostic Accuracy of Fine Needle Aspiration Cytology, Triple Test and Tru-cut Biopsy in the Detection of Breast Lesion
Authors: Agarwal Nirmal Kumar , Choudhury Dhirendra Nath , Minocha Akshit
Published: December 2023

Background: The majority of breast illnesses manifest as a palpable mass. The vast majority of breast lesions are not malignant, and the vast majority of benign lesions do not progress to cancer; however, the accuracy of diagnosis can be improved by a combination of preoperative tests such as physical examination, mammography, fine-needle aspiration cytology (FNAC), and Trucut needle biopsy (TCNB) or core needle biopsy (CNB). FNAC has gained in popularity and is now the primary treatment performed after a history and clinical examination to diagnose solid and cystic breast masses. This study was designed to assess the accuracy of FNAC in comparison to Triple Test and TCNB for the diagnosis of breast masses. Methodology: From January 2023 through May 2023, this study was conducted in the Tezpur Medical College and Hospital. The research included all female patients over the age of 20 with clinically palpable lumps. Palpable breast lumps need a complete clinical breast examination, imaging, and tissue sample for a clear diagnosis to rule out cancer.The Ultrasonography/Mammography, FNAC and tru-cut biopsy procedures were performed concurrently in the same region, and the results were compared to final histopathology as the gold standard. Result: The majority of the patients in the study were in age group of > 60 years. In our study Left breast was involved in 41 (58.5%) patients and right breast in 29 (41.4%) patients. The most frequent site involved was upper outer quadrant in 38 (54.2%). The overall sensitivity of FNAC in our study was 93.75%, tru-cut biopsy is 100% and that of triple test is 100% and specificity for malignancy was 91.6%, 93.6 and 95.6% for FNAC, tru-cut biopsy and triple test respectively. Conclusion: All three techniques have advantages and disadvantages. Core Needle Biopsy cannot be used in place of FNAC, and it is not required to identify all breast lesions. It can be utilised as an adjuvant in circumstances when cytology is definitive and biomarker tests are required. triple test and trucut were more accurate than FNAC in our testing.Trucut biopsy was able to provide histological diagnosis, and the findings were 100% consistent with the final histopathology report.
The Paraganglioma of the Bladder in a Patient with Von Hippel-Lindau Syndrome
Authors: Dalar Sevda
Published: December 2023

Paragangliomas are neuroendocrine neoplasms. They can be functional or non-functional. Although they can be seen in different localizations, they are rarely seen in the bladder. They may accompany hereditary syndromes. In this case report, a case of paraganglioma located in the bladder in a patient followed up with VHL syndrome is presented.
Incidence of Post-operative Pulmonary Complications Following Cytoreductive Surgeries and HIPEC- A Retrospective Analytic Study
Authors: Sureshan Roopesh , B Satheesan , Opneja Sonali , C Jashma , P Joona , Divakaran Namratha , John Mayan
Published: December 2023

Background and aims: Cytoreductive surgery (CRS) is performed to treat macroscopic disease and Hyperthermic intraperitoneal chemotherapy (HIPEC) is used to treat the microscopic residual disease. Abdominal surgeries are sometimes associated with pulmonary complications and also prolonged hospital stays. The aim of this retrospective study was to determine the incidence of post-operative pulmonary complications occurring within 30 days following CRS and HIPEC. The risk factors responsible were also identified. Materials and methods: The retrospective study was done in patients who underwent CRS and HIPEC. Patient’s data was retrieved from 31st May 2018 to 30th June 2022. The data was obtained from the patient records and registers kept in the medical records library. Post operative pulmonary complications were noted and risk factors were identified. Results: There were 27 surgeries of CRS with HIPEC during the study period.The procedure was done in patients with the primary tumour of ovary, colon, appendix, ewings sarcoma pelvis and peritoneum. 6 patients developed post operative pulmonary complications. The complications included pleural effusion in 4 patients and acute respiratory distress syndrome (ARDS) in 2 patients. Conclusion: The incidence of postoperative pulmonary complications in our study was 22 % following CRS and HIPEC. Pleural effusion was the common complication noted, followed by (ARDS). The intrinsic disease in association with hypoalbuminemia (< 2gm/dl) was found to be an important factor for causing pleural effusion.
Assessment of Knowledge about Palliative Care among Registered Nursing Professionals: A Prospective Cross-Sectional Study in a Tertiary Care Hospital in Central India
Authors: Bansal Shashank , Jinwala Prutha , Asati Vikas , Banappagoudar Sudharani B , Elhence Aditya , Shrivastava S P , Patidar Rajesh , Singhai Pankaj , Patel Swati , Chitalkar P. G.
Published: December 2023

Objective: This study aimed to assess the palliative care knowledge among the registered nurses working in tertiary care hospital in Madhya Pradesh. Methods and materials: A prospective cross-sectional study was conducted on 160 registered nurses working in different departments in tertiary care hospital in Madhya Pradesh, who were selected through a purposive sampling technique. The data was collected through an online questionnaire for the socio-demographic variables and validated a self-report questionnaire to measure the knowledge of health care professionals in palliative care and the data was analysed by IBM-SPSSv26. Results: A total of 160 participants enrolled in the study. Basic knowledge care was quite high among the samples (83.75%). Item 1,2 of pain in palliative care was quite high (83.43%) and item 3,4,5 has (22%) only, overall management of pain knowledge was (47%) which is on the lower side. The use of Morphine was 31.04%, Dyspnoea Management it was 38.33%, and in the communication of prognosis, it was 81.56%. Resuscitation knowledge was 46.85%, Psycho spiritual was 24.06% and Bereavement care was 69%. Conclusion: One of the biggest challenges in providing excellent palliative care is that nurses don’t know enough about it. Therefore, improving the quality of palliative care services provided to patients could be accomplished by increasing their knowledge through in-service education and retraining on the job.
Percutaneous Transhepatic Biliary Drainage for Malignant Biliary Obstruction in Advanced Solid Organ Malignancy: Clinical Outcomes and a Perspective on Quality of Life
Authors: Vaitiekunas Laurence , Caird Susan , Eriksen David
Published: December 2023

Background: Malignant obstructive jaundice is associated with a poor prognosis. Patients can undergo percutaneous transhepatic biliary drainage (PTBD), but the impact it has on quality of life is not well understood.Objective: To assess the potential impact of PTBD on quality of life in patients with obstructive jaundice from advanced malignancy using surrogate markers including complications, hospital length of stay, readmission, reintervention, and mortality. Methods: A retrospective analysis of a single-centre cohort of all patients with advanced solid organ malignancy undergoing PTBD between April 2020 and February 2022. Data was collected from electronic medical records.Results: Among the sixteen patients, abdominal pain and cholangitis were observed in 62.5% and 37.5% patients, respectively. Peritonitis, biliary leak, perihepatic abscess, and haemobilia occurred in individual cases. The median hospital length of stay post PTBD was nine days. The 30-day readmission rate for PTBD-related complications was 31.3% with a median of three total readmissions per patient. The 30-day reintervention rate was 62.5%. The 30-day all-cause mortality was 25% (95% CI:8.9-53.3), which included one procedure-related death. Conclusions: Quality of life in patients with obstructive jaundice from advanced solid organ malignancy undergoing PTBD can be adversely impacted due to the high risk of complications, reintervention, hospitalisation, and mortality. Thorough patient assessments are crucial in selecting appropriate candidates for PTBD.
Утвердження монополії більшовицької партії на владу в Україніна початку 1920-х рр.
Authors: Кузмінець Наталія
Published: December 2023

The article examines the hostile attitude of the Bolshevik Party towards its political opponents, shows the actions of the party's top leadership of the RCP (b), party and Soviet bodies and special services to eliminate the opposition national-communist and socialist parties, and the establishment of the soviet one-party system in Ukraine in the early 1920s.  In the article, the author traces the stages of the elimination of opposition parties by the Bolsheviks in Ukraine in the early 1920's. Initially, the Bolsheviks were forced to establish their power, relying for the the parties union, as a purely Ukrainian and so a all-Russian. After consolidating in the country, the Bolshevik Party decided to eliminate the Borotbists and bobbyists and their independent political activity, which was aimed at building Ukraine according to theirs own views. Applying ideological methods of influence on Borotbists and bobbyists, the Bolsheviks led these parties to self-destruction, leaning of the leaders of these parties. The left side of these parties has joined the ranks of the Bolsheviks.The second stage was more connected with the gradual cessation of the activities of All-Russian Socialist-Revolutionary and Menshevik parties in Ukraine. With the introduction of the NEP increased pressure for these parties. It was in 1921 that the Bolsheviks started a course the sole political existence. The SRs and the Mensheviks made a number of attempts to restore their former influence on the population, but all their attempts were neutralized by the Bolsheviks. The last UPP ceased to exist in 1925 in Ukraine and one-party regime was established . The status of the ruling party with all the institutions of power gave advantages to the Bolsheviks in relation to other parties. Using political, ideological, moral pressure, repression and terror, the Bolsheviks successfully completed the task of eliminating their political opponents. Multipartyism could not be from an ideological point of view.
Você pode não saber topologia, mas a topologia sabe você (ou por que predispor-se a esse estudo e sua aplicação clínica)
Authors: Silveira Lia Carneiro
Published: December 2023

O estudo da topologia coloca para a formação do analista a necessidade de um esforço a mais, um investimento em algo que, não raro, é visto como muito difícil e ou até mesmo considerado dispensável. Mas seria mesmo esta apenas mais uma ferramenta entre outras? A partir da experiência com um caso que me desafiou na clínica e de como o encontro com a topologia permitiu avançar em relação a ela, desenvolvo nesse texto algumas razões pelas quais entendo que vale a pena se aventurar por este campo.
Editorial
Authors: Furtado Luis Achilles Rodrigues
Published: December 2023

Editorial
Qual o preço do amparo? Da alienação violenta no amor à mortificação da não-escuta
Authors: Araujo Carla
Published: December 2023

O presente trabalho parte de uma experiência vivenciada em um dispositivo da rede socioassistencial voltado para mulheres em situação de violência e busca ponderar sobre o que pode o psicanalista dentro de uma instituição cujo discurso muitas vezes tende ao universal. Sabendo, com Lacan, sobre a impossibilidade de pensar sobre a existência d’A mulher, intenta-se, a partir de uma resenha clínica e da leitura da tábua da sexuação, lançar um olhar que possibilite um espaço de escuta para o sujeito, para além dos ideias institucionais, da vitimização e da tutela, de forma que algo do desejo e do gozo nas parcerias possa ser ouvido.