bluuebunny/crossref_metadata_2025 huggingface dataset:
The The Effects of Centella asiatica Extract (CAE) on Methamphetamine-Induced Neurotoxicity via Human Neuroblastoma Cell Line
Authors: Mat Zain Mazatulikhma Mat Zain , Shamsuddin Nursyamila , Ahmad Noorden Mohd Shihabuddin
Published: November 2021

Methamphetamine (METH) was reported to caused neurotoxicity and cell death, in vitro. Centella asiatica or ‘pegaga’ is a native tropical herb with antioxidant and neuroprotective activities. Although the effects of Centella asiatica against oxidative stress and neuronal cell death have been reported in previous studies, however, the potential effects of Centella asiatica against psychostimulant methamphetamine (METH) are limited. Therefore, this study was aimed to evaluate the effects of Centella asiatica extract (CAE) against METH on all-trans retinoic acid, RA-differentiated human neuroblastoma, SH-SY5Y cells. The RA-differentiated SH-SY5Y cells were used to resemble dopaminergic neuronal-like cells. Cell viability was quantitatively assessed by 3-(4,5-dimethylthiazol-2-yl)-2 tetrazolium bromide, MTS assay.  CAE at varying concentrations from 1pg/mL to 1mg/mL significantly decreased the viability of the undifferentiated SH-SY5Y cells in a concentration-dependent manner. At 1mg/mL of CAE, significantly increased the viability of differentiated SH-SY5Y cells. Meanwhile, CAE at 100µg/mL and 1mg/mL significantly reversed the METH-induced neuronal cell death. The results revealed that promising treatment of CAE on METH-induced neurotoxicity is mediated by its high content of asiaticoside, asiatic acid, madecassoside and madecassic acid. Taken together, this study may suggest CAE as a potential therapeutic treatment for METH-induced neurotoxicity, in vitro.
ANALISIS PENGARUH NPL, CAR, BOPO DAN IRR TERHADAP PERTUMBUHAN KINERJA KEUANGAN BANK YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2011-2015
Authors: Nurul Ichsan Reza , Nasution Lukman
Published: November 2021

This study aims to determine whether NPL, CAR, BOPO, and IRR affect the growth of financial performance of banks listed on the IDX, either partially or simultaneously. This research method is multiple linear regression. The banking company studied was a foreign exchange National Private Commercial Bank (BUSN) listed on the Indonesia Stock Exchange (BEI). This study uses secondary data obtained from the Indonesia Stock Exchange website, namely www.idx.co.id using a sample of 16 companies from a population of 23 banking companies during the 2011-2015 period. From the research results obtained multiple linear regression equation Y = 0.995 + 0.002NPL– 0.008BOPO- 0.025CAR + 0.009IRR. The results of this study indicate that partially the IRR variable has an effect on ROA, while the NPL, CAR and BOPO variables have no effect on ROA while simultaneously NPL, CAR, BOPO, and IRR have an effect on ROA. The value of R = 0.716, meaning that the relationship between the variables NPL, OEOI, CAR and IRR on ROA is 71.6% or in other words the relationship between variables is strong. Meanwhile, the value of Adjusted R ^ 2 is 0.487 or 48.7%, which means that the effect of NPL, CAR, BOPO and IRR on Return on Assets (ROA) is 48.7%. While the remaining 51.3% is influenced by other variables which are not used in this study.
RETURN SAHAM PERUSAHAAN SUBSEKTOR PROPERTI DAN REAL ESTATE DI INDONESIA: RASIO LIKUIDITAS, RASIO SOLVABILITAS, DEGREE OF LEVERAGE
Authors: P. Geno Much. Rizal , Nuradmanta Rizky Windrasta , Firmansyah Amrie
Published: November 2021

Keuntungan dalam berinvestasi di pasar modal dapat dicerminkan melalui perolehan return atas saham yang dipilih. Saat ini, semakin banyak investor yang berminat berinvestasi di perusahaan properti. Bisnis properti sangat menjanjikan dikarenakan tingginya permintaan dari masyarakat dan harga jual properti yang memiliki kecenderungan selalu naik. Penelitian ini bertujuan untuk menguji pengaruh rasio likuiditas, rasio solvabilitas, dan degree of leverage terhadap return saham. Penelitian ini menggunakan sampel data keuangan perusahaan yang bergerak di subsektor properti dan real estate yang terdaftar di BEI pada periode tahun 2012 s.d. tahun 2019. Hasil penelitian ini menunjukkan bahwa solvabilitas berpengaruh positif terhadap return saham sedangkan likuiditas, operating leverage dan financial leverage tidak berpengaruh terhadap return saham perusahaan.
PENANGANAN PEMBIAYAAN BERMASALAH PADA PEMBIAYAAN AKAD MURABAHAH DI PT. BPRS BOGOR TEGAR BERIMAN CABANG
Authors: Marlina Asti , Sopiandi Aulia Eka
Published: November 2021

Pembiayaan merupakan salah satu fungsi utama lembaga keuangan, terutama lembaga keuangan bank. Terdapat beberapa bentuk akad pembiayaan pada perbankan syariah, salah satunya pembiayaan dengan akad Murabahah. Dan dalam suatu lembaga perbankan tidak bisa terhindar dari suatu masalah, salah satunya risiko pembiayaan. Pembiayaan bermasalah merupakan pembiayaan tidak lancar yang dialami oleh pihak BPRS dimana nasabah tidak dapat atau tidak mau memenuhi kewajiban untuk membayar kembali dana yang dipinjamnya secara utuh pada saat jatuh tempo maupun sesudahnya. Dari latar belakang ini, penelitian ini dilakukan untuk mengetahui bagaimana prosedur pembiayaan Murabahah hingga bagaimana langkah PT. BPRS Tegar Beriman dalam melakukan penanganan pembiayaan bermasalah
Tendensi Kinerja dan Proyeksi Pertumbuhan Bisnis Asuransi di Masa Depan
Authors: Triani Neks , Abbas Ahmad , Syahrir Sasmita Nabila
Published: November 2021

Penelitian ini bertujuan untuk menganalisis tendensi kinerja dalam laba yang dilaporkan oleh perusahaan asuransi di Indonesia dan memproyeksikan pertumbuhan bisnisnya di masa depan. Sampel penelitian ini terdiri dari perusahaan asuransi yang terdaftar di Bursa Efek Indonesia dan laporan keuangan menggunakan data periode 2013-2018. Variabel penelitian diuji menggunakan model efek signifikansi logistik. Temuan penelitian ini mengungkapkan bahwa rerata tendensi kinerja perusahaan asuransi menyimpang dari laba aktualnya dan rerata prospek bisnisnya diproyesikan mengalami laju pertumbuhan negatif di masa mendatang. Berdasarkan pada uji efek signifikansi, hasilnya menemukan bahwa laba perusahaan asuransi yang dilaporkan menyimpang cenderung melemahkan pertumbuhan bisnis.Kata kunci: Bisnis Asuransi; Laba; Pertumbuhan.
Information System Success: Influence to Consumer Behavior in the Use of Mobile Payment in M-Commerce
Authors: Pelegrin Mark Anthony L.
Published: November 2021

Both businesses and consumers have experienced significant changes as a result of the rise of m-commerce. The benefits of using a new system are perceived by users depending on their assessment of the system, information, and service quality. In one of the cities in the Cavite area, the researcher wants to assess the influence of information system success in customer behavior in mobile payments in m-commerce. This study consisted of 405 respondents and used purposive and quota sampling with a descriptive quantitative design and a survey questionnaire as the instrument. Analysis of variance, multivariate analysis of variance, and independent-sample t-test was considered as statistical techniques that will help determine consumer behavior in the use of mobile payment in m-commerce. This study's findings have numerous key implications for the usage of mobile payments in m-commerce research.
EFEKTIVITAS PENGGUNAAN INFOGRAFIS ALUR DALAM PENYAMPAIAN INFORMASI
Authors: Sari Widya , Yani Aditya Rahman , El-Chidtian Aileena Solicitor Costa Rica
Published: November 2021

In this modern era, there has been a need for practical and interesting information to the public. Likewise, UPN "Veteran" Jawa Timur continues to improve the model of information delivery from Standard Operating Procedures (SOPs) in its academic service system. This research was conducted to find a solution in creating a model of delivering that information using visual infographic style. Visual infographic style can combine information with design that can help individuals and organizations communicate briefly and clearly to the audience. The type of infographic used is the type of infographic that explains the flow in stages in various models will be measured their level of effectiveness. The research method used is qualitative and quantitative methods, namely by conducting literature studies, interviews and observations. The data obtained will be analyzed using the TOWS Matrix, an analysis of the target audience's insights using the why test method, the preparation of the questionnaire, and the inference of the results of the questionnaire. Through this infographic media, it is expected that information about SOPs in the academic service system can be conveyed clearly and easily understood by UPN "Veteran" Jawa Timur students.
REPRESENTASI VISUAL IMAGE DALAM FOTOGRAFI LANDSCAPE ANSEL ADAM
Authors: Darmawan Yurif Setya
Published: November 2021

Alam liar di daerah Amerika Barat (Wildwest) merupakan sebuah tempat yang sering dijadikan subjek fotografi sejak pertengahan abad 19, (Weber, 2002). Pada tahun 1860an, seorang fotografer bernama Charleton Watkins menyusuri San Fransisco hingga sampai pada lembah Yosimite. Charleton Watkins mengabadikan hamparan pemandangan lembah Yosimite menggunakan alat kamera dan menyimpannya dalam kepingan material film. Bersamaan dengan ditemukannya proses perekaman image foto kedalam kepingan film sehingga memberikan semangat manusia untuk melakukan ekspedisi di daratan Amerika. Fotografi diperthitungkan sebagai alat saintifik yang sempurna, fotografi dapat dijadikan sebagai bukti otentik dokumentasi di bidang keilmuan geografi, arkeologi, topografi dan lain sebagainya.
KAJIAN DESAIN ENVIRONMENTAL GRAPHIC DESIGN UMEDA HOSPITAL
Authors: Hananto Brian Alvin , Timothy Eldad , Krisananda Rafi , Stefanus Togu
Published: November 2021

Environmental graphic design (EGD) adalah sebuah obyek desain grafis yang belum banyak dibahas karena seringkali dinilai inferior. Hal itu dikarenakan EGD seringkali dinilai hanya ‘melengkapi’ desain interior ataupun arsitektur yang secara volume lebih tinggi dibangingkan EGD, namun hal itu bukan berarti EGD merupakan sebuah obyek desain yang remeh. Tulisan ini akan membahas EGD dari Umeda Hospital yang didesain oleh Kenya Hara. Kajian terhadap desain tersebut dilakukan dengan melihatnya sebagai obyek desain grafis: memiliki elemen gambar dan tulisan. Dengan melihat relasi antara kedua elemen tersebut dalam EGD Umeda Hospital, penulis mendapatkan kesimpulan bagaimana EGD tersebut dirancang tidak hanya fungsional semata, namun juga konseptual dan juga memiliki pertimbangan estetik yang tidak kalah penting. Penulis berharap tulisan ini dapat menunjukkan otoritas dan mungkin kompleksitas dari disiplin desain grafis dalam perancangan EGD yang tidak kalah dengan disiplin ilmu lainnya.
Comparisons of Propensity Score Methods for Time to Event Outcomes: Evaluation through Simulations and Oral Squamous Cell Carcinoma Case Study
Authors: Ma Sophie , Said Badr Id , Hosni Ali , Xu Wei , Keshavarzi Sareh
Published: November 2021

Introduction & Objective: In observational studies, it is recommended to use propensity score (PS) methods or covariate adjustment for confounding effect adjustment. However, few guidelines are available regarding the choice of PS approaches or covariate adjustment for the best performance in a particular data. In this study, we compared different PS methods and conventional covariate adjustment to investigate the treatment effect for the overall population on time-to-event outcomes.

Methods: In the Monte Carlo simulations, we compared the hazard ratio (HR) and precision estimated using covariate adjustment and eight different PS approaches, including matching, stratification, and inverse probability of treatment weighting (IPTW). In the Oral Squamous-Cell Carcinoma Cancer case study, we applied the aforementioned PS approaches to compare the effect of receiving post-operative radiation therapy (PORT) and having engraftable tumors on different time-to-event clinical outcomes.

Results: In the simulations, both IPTW and covariate adjustment produced unbiased HR estimates with small uncertainty. In the case study, covariate adjustment showed that patients with engraftable tumors were twice as likely to have local/regional recurrence (HR 1.98 [1.23, 3.18], p-value<0.005) and any recurrence or death (HR 2.02 [1.38, 2.96], p-value<0.001); patients received PORT were twice as likely to develop either local, regional, or distance recurrence (HR 2.12 [1.32, 3.41], p-value<0.005). Results produced by IPTW were consistent with covariate adjustment method (within ± 0.1 differences).

Conclusion: Covariate adjustment and the IPTW method performed well across simulations and the case study. In practice, care should be taken to select the most suitable method when estimating the treatment, exposure or intervention effect on time-to-event outcomes.
Performance of statistical methods to address treatment non-adherence in pragmatic clinical trials with point-treatment settings: a simulation study
Authors: Hossain Md Belal , Mosquera Lucy , Karim Mohammad
Published: November 2021

Introduction: The instrumental variable (IV)-based methods (e.g., two-stage least square [2SLS], two-stage residual inclusion [2SRI], and nonparametric causal bound [NPCB]) can be used to address non-adherence in pragmatic trials. These methods require assumptions, e.g., exclusion restriction, although they are known to handle unmeasured confounding. The inverse probability-weighted per-protocol [IPW-PP] method is useful in the same setting but requires different assumptions (no unmeasured confounding). Although all these methods aim to address the same problem, comprehensive simulations to compare their performance are absent in the literature. We performed extensive simulations when (1) confounding is present, (2) confounder is unmeasured but exclusion restriction is met, (3) exclusion restriction is violated, and (4) non-adherence is one-sided and differential.

Method: We compared the performance in terms of bias, standard error (SE), mean squared error (MSE), and 95% confidence interval coverage probability.

Results: For setting-1, IPW-PP outperforms IV-methods in terms of bias, SE, MSE, and coverage for <80% non-adherence but produces high bias beyond that point. IPW-PP also has high biases, but 2SLS and 2SRI work well for setting-2. For setting-3, 2SLS and 2SRI perform the worst in all scenarios; IPW-PP produces unbiased estimates when necessary confounders are measured and adjusted. For setting-4, IPW-PP has less bias, but 2SLS and 2SRI have higher SE and MSE. NPCB has wider bounds in all scenarios. We also analyze a two-arm trial to estimate the effect of vitamin A supplementation on childhood mortality after addressing non-adherence.

Conclusion: We need to be cautious using the IPW-PP when non-adherence is very high or strong unmeasured confounding and should avoid using the IV methods when the exclusion restriction assumption is violated or high differential non-adherence. Since assumptions are different and often untestable for IPW-PP and IV methods, we suggest analyzing data using both methods for a robust conclusion.
Translations for Our Nations: Addressing the Indigenous Language Gap in COVID-19 Health Communication
Authors: Yohathasan Thilaxcy , Stutz Sterling
Published: November 2021

Purpose: The availability of culturally safe and plain-language resources is necessary to reduce the spread of COVID-19 for Indigenous communities around the world. Translations For Our Nations is an initiative addressing these resource gaps, making available COVID-19 health resources in Indigenous languages on the web. The project began in April 2020 as a result of the Indigenous COVID-19 Health Partnership launched by Victor A. Lopez-Carmen, a Dakota and Yaqui medical student, Harvard Medical School) and co-founded by Sterling Stutz and Thilaxcy Yohathasan, (MPH-Indigenous Health at the University of Toronto), and Sukhmeet Singh Sachal (medical student, University of British Columbia).

Methods: Translators from Indigenous communities around the world signed up to participate in the project via a GoogleForm in April 2020. Over 100 Indigenous translators and community members in regions (South America, Asia, Africa, Europe, North America, and the Pacific) were provided the 5 English language source materials reviewed by physicians and Indigenous youth leaders. Translators submitted their translated documents via email and on September 1, 2020 the website Translations4OurNations.org was launched where the translated documents can be accessed and downloaded with more translations accepted on a rolling basis.

Results: Translations for our Nations has published COVID-19 health resources in 40+ Indigenous languages from around the world. The website also includes photos and text submissions from community members speaking to the importance of culturally-specific COVID-19 health information disseminated directly to communities in local languages and dialects.

Implications:  Indigenous Nations have the right to access vital health information in their mother tongue. This project is led by and designed for Indigenous youth and Indigenous community members to empower individuals and communities to make informed choices regarding their health and exposure risks, and decrease the risk of COVID-19 transmission in Indigenous communities around the world.
Análisis del ciclo de vida aplicado para la evaluación ambiental en la reutilización del pavimento rígido. Caso de estudio vía Cuenca- Girón- Santa Isabel
Authors: Orellana Albán Sandy Tamara , Coronel Sacoto Diego Fernando
Published: November 2021

Introducción: La red vial estatal, está expuesta y es vulnerable a la acción de los desastres naturales, y el cambio climático incrementa los riesgos de destrucción, amenazando la infraestructura actual y futura. La ubicación geográfica del Ecuador y su geomorfología hacen que las carreteras de la red nacional sean propensas a amenazas de terremotos, deslizamientos, inundaciones y actividad volcánica, condiciones que generan interrupciones en actividades y servicios que dependen de la red vial nacional, sumado a esto, el hecho que muchas vías ya han cumplido su ciclo de vida. Objetivo: El objetivo de la presente investigación es analizar los posibles impactos ambientales que se podrían reducir con la reutilización del pavimento rígido, en la vía Cuenca- Girón- Santa Isabel, aplicando la herramienta de Análisis de Ciclo de Vida. Metodología: Se empleó la metodología estandarizada del Análisis del Ciclo de Vida (ACV), conforme lo establece la Norma ISO 14040, utilizando el software SimaPro 9.1.1, con licencia de la Universidad Católica de Cuenca, utilizando el método de evaluación el CML-IA baseline, y la base de datos Ecoinvent, que permite analizar las categorías de impacto. Resultados: Los resultados muestran que las categorías de mayor contribución a los impactos ambientales son: Agotamiento abiótico (80%), Calentamiento Global (30%), Agotamiento abiótico (combustibles fósiles) (50%), Toxicidad humana (80%), Ecotoxicidad acuática marina (30%), Ecotox acuático de agua dulce (30%), y la etapa que mayor contribuye a la contaminación ambiental es la etapa de transporte de carga pesada con un 80 % por emisiones esto debido al consumo y producto de la combustión de diésel y otros combustibles. Conclusión: La reutilización del pavimento rígido si presenta menores impactos ambientales, sin embargo, el uso y consumo de combustible determinaría su factibilidad en cuanto a los costos que se generen para la reutilización del pavimento que ha cumplido su ciclo de vida. La metodología ACV puede ser utilizada como herramienta con ciertas limitaciones, para la evaluación ambiental y la factibilidad para su difusión en el país.
El Museo de la Cultura Indígena de Tihosuco y el conflicto de la Guerra de Castas: la cohesión social a través del turismo de la memoria
Authors: Medina Cecilia del Socorro , Pérez González Elena M.ª
Published: November 2021

La Guerra de Castas fue un hecho histórico ocurrido en la selva de la Península de Yucatán a finales del siglo XIX. En el año 1993, se inauguró un museo dedicado a este conflicto, en torno al cual giran diferentes iniciativas locales turísticas en la región. Este museo, denominado Museo de la Cultura Indígena en Tihosuco, en Quintana Roo, es comúnmente conocido como el Museo de la Guerra de Castas y difunde un peculiar binomio de argumentos en torno al conflico: uno para la comunidad local y otro para los turistas.
Habeas Corpus como garantía del derecho a la vida e integridad en el Ecuador
Authors: Soria-Carpio Clara
Published: November 2021

Este ensayo busca presentar un acercamiento a la acción de habeas corpus como una garantía adecuada y eficaz ante la vulneración del derecho a la vida y a la integridad física de las personas privadas de libertad en el Ecuador. Normativamente, el conocido como habeas corpus correctivo ha sido establecido desde hace más de diez años en el régimen constitucional ecuatoriano; sin embargo, se lo ha considerado desde una concepción tradicional: aquella acción que busca verificar si han existido causales de ilegalidad, ilegitimidad y arbitrariedad frente a una privación de libertad.La constante actualización jurisprudencial que ha desarrollado la Corte Constitucional propone nuevos retos a la sociedad, a los litigantes y a los jueces, ya que se han establecido los primeros parámetros prácticos a considerar ante las innegables vulneraciones a la integridad de las personas privadas de libertad y, a la vez, se ha ratificado al habeas corpus, como la garantía adecuada y eficaz para proteger la vida y la integridad de las personas privadas de libertad.
Vaccine Hesitancy: Past and Present in the COVID-19 Era
Authors: Lin Leesa , Larson Heidi J
Published: November 2021

Vaccine-hesitant individuals are a heterogeneous group that are indecisive in varying degrees – more of a spectrum – about specific vaccines or vaccination in general. Vaccine hesitancy is complex, varying by vaccine, time, context, geographic region, and sub-population. There is an “infodemic” that needs to be fought alongside the pandemic as exposure to misinformation is linked to a reduction in an individual’s intentions to vaccinate. In addressing vaccine hesitancy, it is key to 1) identify the subpopulations susceptible to vaccine hesitancy, 2) diagnose issues through various research methods – surveys, in-depth interviews, focus groups, or media monitoring – and 3) develop context-tailored, evidence-based interventions to address those reasons. Sensitivity to the context and effective communication are key to successful immunization programs, alongside other critical factors (confidence, complacency and convenience – the 3Cs model); engaging stakeholders in dialogue is critical to intervention design and implementation.
Перспективи впровадження електронного рекрутингу у Збройних Силах України
Authors: Kosevtsov Vyacheslav , Tikhonov Grigory , Bilyk Aleksandr
Published: November 2021

Стаття присвячена дослідженню процесу впровадження електронного рекрутингу у провідних країнах світу та Збройних Силах України його використання у практичній роботі керівників військових організаційних структур з метою підвищення спроможностей її персоналу у виконанні завдань, що стоять перед нею. Розглянуті сучасні наукові тенденції щодо визначення системи рекрутінгу та питання з підвищення його ефективності, сформовано основні проблемні аспекти питань його впровадження та оцінки. Визначено напрямки удосконалення оцінки персоналу на основі рекрутінгу, здійснено їх загальну характеристику та шляхи подальшого його розвитку.
Custo-efetividade das abordagens terapêuticas da leucemia linfocítica aguda em pacientes pediátricos
Authors: Cavalcante Francisca Thaís de Sousa , Lima Thayana Maria Navarro Ribeiro de , Bezerra Paula Maria Maracajá , Vieira Thiago Isidro , Cavalcanti Yuri Wanderley , Sousa Simone Alves de
Published: November 2021

Objetivo: Realizar uma análise de custo-efetividade dos protocolos antineoplásicos mais utilizados no tratamento da leucemia aguda em pacientes pediátricos. Métodos: Realizou-se uma análise de custo-efetividade, com uso de modelo de árvore de decisão, a partir da consulta de dados secundários de sistemas de informação em saúde do Brasil, o SIGTAP - SUS. A população foi composta por pacientes pediátricos registrados na base de dados do RHC do INCA, na faixa-etária de 0 a 19 anos, apresentando leucemia linfocítica/linfoide/linfoblástica como neoplasia de base, no período de 1997-2017. Resultados: Para os pacientes do sexo masculino, o transplante de medula óssea (TMO) exibiu um custo incremental alto em relação às alternativas e demonstrou a menor efetividade. O tratamento realizado com Qt associada ao TMO (QtTMO), embora de custo incremental maior, apresentou efetividade muito superior às alternativas, tornando-se custo-efetiva. A associação de Qt com radioterapia (QtRxt) se revelou o tratamento com maior custo-efetividade. Para o sexo feminino, o tratamento realizado com QtTMO se apresentou como o menos custo-efetivo, juntamente com o TMO. Por sua vez, a QtRxt se mostrou com custo-efetividade maior em relação às alternativas. Conclusão: Os resultados desta análise econômica revelaram melhor custo-efetividade para a QtRxt e pior custo-efetividade para a TMO, em ambos os sexos. Essa análise mostrou diferentes cenários de acordo com o sexo do paciente, em particular, o tratamento com QtTMO pode constituir uma opção terapêutica custo-efetiva para os pacientes do sexo masculino, porém não para os do sexo feminino.
Estratégias de reprodução socioeconômica da agricultura familiar no cerrado piauiense
Authors: Silva Antonio Joaquim da , Barbosa Eriosvaldo Lima , Santos Laudenides Pontes dos , Vieira Valdira de Caldas Brito , Chaves Sammya Vanessa Vieira , Silva Júnior Francisco José da
Published: November 2021

Este artigo pretende examinar como os agricultores familiares de Uruçuí, Piauí, marcados por um patrimônio de saberes e práticas tradicionais que se ajustam à modernidade, constroem as suas estratégias de reprodução econômica para o atendimento das suas necessidades de produção e consumo, haja vista o município se consolidar nas atividades do agronegócio globalizado, o que tem causado incertezas sobre o futuro do trabalho agrícola familiar. A análise se embasa no método etnográfico, por meio de observações sistêmicas e aplicação de entrevistas semiestruturadas com 254 agricultores familiares, distribuídos em 17 comunidades rurais do município, cujas perguntas envolveram questões sobre a terra, o trabalho e as relações com o mercado. Concluiu-se que a agricultura familiar de Uruçuí manifestava uma grave crise social marcada, sobretudo, por parcos rendimentos financeiros e dificuldades de acesso às linhas de crédito rurais, o que comprometia a produção familiar, repercutindo na economia de aprovisionamento e na pluriatividade.
Enfermagem, doação de órgãos e aspectos legais: Diagnóstico situacional no Brasil e em Roraima
Authors: Freitas Adriana Gomes de , Figueiredo Dionah Bandeira de , Teixeira Sabrina Torres , Ramos Ricardo Luiz , Machado Helenira Macêdo Barros
Published: November 2021

O estudo busca refletir acerca das diretrizes e orientações da política nacional da doação de órgãos, assim como descrever as variáveis envolvidas no procedimento aliado à atuação do profissional de enfermagem, com enfoque na estrutura organizacional do Estado de Roraima. Trata-se de uma pesquisa de cunho exploratório descritiva com abordagem qualitativa, onde a coleta de dados se fez por meio de revisão sistemática de literatura nos bancos de dados LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SciELO (Scientific Eletronic Library Online) e BVS (Biblioteca Virtual em Saúde), assim como documentos oficiais do Ministério da Saúde e outras Instituições Competentes, disponibilizados eletronicamente. Em sequência os dados foram agrupados e expostos em quadros. A pesquisa forneceu um diagnóstico situacional do Estado de Roraima, tendo como diferencial a abordagem do papel da Enfermagem nesta área de atuação, tendo em vista que este profissional está envolvido ininterruptamente na assistência do paciente e seus familiares, de forma a esclarecer os anseios e dúvidas quanto a doação de órgãos em todos os seus processos.
Impacto do ensino remoto na saúde mental de discentes universitários durante a pandemia da Covid-19
Authors: Pessoa Juliana dos Santos , Ginú Isabel Luiza do Nascimento , Carneiro Lucilla Vieira , Silva Vitória Polliany de Oliveira , Matias Lucas David Maia , Melo Vilma Felipe Costa de
Published: November 2021

Objetivo: Analisar a produção científica acerca do impacto do ensino remoto na saúde mental de discentes universitários durante a pandemia da Covid-19. Método: Trata-se de um estudo descritivo do tipo revisão integrativa da literatura. A busca dos artigos foi realizada por meio da Biblioteca Virtual em Saúde (BVS), nas bases de dados Medical Literature Analysis and Retrieval System Online (MEDLINE), Base de Dados em Enfermagem (BDENF), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Índice Bibliográfico Espanhol em Ciências da Saúde (IBECS), com a utilização dos Descritores em Ciências da Saúde (DeCS): “infecções por coronavírus”, “saúde mental” e “estudantes”, unidos com o operador booleano “AND”. Resultados: As buscas nas bases de dados resgataram 145 artigos. No entanto, após a leitura deles, a amostra final foi composta por 6 artigos que atenderam os critérios de elegibilidade estabelecidos. As evidências científicas demostraram os principais prejuízos do ensino remoto para a saúde mental dos universitários frente a pandemia da Covid-19. Houve destaque para os sintomas de ansiedade e depressão. Conclusão: Diante do atual cenário, os discentes tornaram-se um público altamente vulnerável ao aparecimento de transtornos mentais, que viabilizam o aparecimento de prejuízos cognitivos, afetando consequentemente o desenvolvimento da aprendizagem.
Quality of life in neuropathic pain: a literature review
Authors: Couto Dyecika Souza , Goulart Guilherme , Luciano Leonardo Luca , Cardoso Edvaldo José Rodrigues
Published: November 2021

Introduction: Neuropathic pain may develop after injury to the central nervous system, peripheral or both, when deleterious changes occur along the nociceptive modulatory pathways of the central nervous system. Proper management requires an interdisciplinary approach, as it can impact quality of life. Objectives: This review of the literature aims to assess the impact of pharmacological and non-pharmacological factors in the quality of life of patients with chronic neuropathic pain. Methodology: A systematized virtual search was carried out in PubMed®, collected articles between January 2010 and May 2020 using the terms “neuropathic pain”, “treatment”, “human” and “systematic review” using the filters of “systematic reviews ”E“ published in the last 10 years ”. All articles were formed by two independent reviewers and tabulated in a spreadsheet using Microsoft Excel® software. Results: Non-pharmacological interventions were addressed by most articles. Some articles addressed pharmacological interventions, with painful diabetic peripheral neuropathy being the main etiology. The most used quality of life measurement tools were: Medical Outcomes Study 36 (SF-36); EuroQol-5 Dimension (EQ-5D) and Beck Depression Inventory Score (BDI). Conclusion: The scarcity of high-quality studies that measure quality of life through validated tools is an obstacle to credible analysis of the impact of interventions on the life of chronic pain patients, however, in a preliminary way, cognitive behavioral therapy and the use of Spray THC/CBD oromucous has the potential to have a beneficial impact on quality of life.
Uma revisão integrativa sobre o uso de plantas aromáticas encontradas na Amazônia na promoção da fitoterapia
Authors: Ramos Lucilane Maria Penaforth , Souza Gabriel Oliveira de
Published: November 2021

Devido as suas propriedades terapêuticas, as plantas aromáticas são bastante utilizadas pela população para fins medicinais, aromatizantes, condimentares e para estudos científicos a respeito das ações farmacológicas: anti-inflamatória, antiespasmódica, antioxidantes, antissépticas, antimicrobianas, calmantes, carminativa, entre outras. Por isso, o objetivo vem com o intuito de facilitar a produção das plantas aromáticas para auxiliar a população e os profissionais da saúde a buscar conhecimentos sobre os efeitos farmacológicos e fisiológicos dos compostos bioativos de cada planta em prol da saúde humana, através da fitoterapia. O trabalho foi embasado em pesquisas de artigos publicados no período de 2013 a 2021 de acordo com a revisão bibliográfica nas plataformas cientificas: SciELO e PUBMED, com respectivas seleções e leituras dos artigos no mês de julho a setembro. No total foram obtidos 30 artigos, nos quais foram excluídos aqueles que continham repetições e não apresentavam contexto compatível com o tema, restando apenas 21 artigos selecionados. Com base, na revisão bibliográfica foram selecionadas 10 espécies de plantas aromáticas (Alecrim; Orégano; Boldo brasileiro; Arruda; Hortelã comum; Erva-cidreira; Capim-limão; Alfavaca; Sálvia; Alfazema), com suas respectivas informações: nome cientifico, nome popular, parte usada da planta, propriedade farmacológica, indicação terapêutica. O estudo identificou dentro da fitoterapia e da medicinal tradicional, diferentes abordagens e costumes acerca do uso correto no manejo de plantas medicinais. Além de contribuir para difundir o conhecimento a cerca dessa classe de plantas (aromáticas), o presente estudo fornece ferramentas com base na leitura acerca da forma do uso para o preparo mais eficiente dessas espécies aqui revisadas.
INFOLOGICAL MODELING TECHNOLOGY PROCESSES OF PERSPECTIVE FOLDED MATERIALS
Authors:   National Transport University, Kyiv, Ukraine, G Baranov , O Komisarenko ,   National Transport University, Kyiv, Ukraine, O Prohorenko ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The article is devoted to the development of methods infolohichnoho modeling and simulation polierhatychnoho documentary describing the test bearing properties nanomaterials that determine the 33 endurance and technological resources mixtures structural components pavement layers in terms the variety effects to cover non-stationary environment and traffic. Formalized mathematical description models and methods necessary for the system CM-PD as hardware and software testing technology polierhatychnoho structure formation nanomaterials under technical and technological orders endurance performance evaluation and resource material layers work surfaces for safe movement traffic forecasting. The peculiarities the modes interaction and the language simulation ergatic modeling for the search rational technologies creation road materials are substantiated. The proposed analytical tools aimed at forming the structure silicon-carbon polymers and composites with expected force-moment and mass-energy physicochemical properties to counteract the effects heterogeneous factors non-stationary environment. The method infological modeling processes for providing conditions for the purposeful between atomic and molecular interactions in the limited local spatial volumes is developed. Formalized parametrization of mutual functions distribution concentrations, pressure and temperatures, which jointly accelerates the stage thermodynamic self-organization and controlledly form the domain-granular structures substances artificial structural materials (SCM) road cover. The information analytical tools the KM-PD system provide the reliability the estimates endurance interval, mechanical strength, integrated resource, obtained by the methods simulation the MSC and in general, KSSSDO. Mixtures substances withstand similar effects from environmental factors and respond equally to microphase spatial separation compatible component components. The maximum levels energy efficiency ordered load bearing coverings are the achievement for the operation the transport and road complex with non-stationary flows moving objects on the surfaces the future ITS infrastructure provided by the agreed levels multiple heterogeneous interactions. KEY WORDS: THERMODYNAMIC SYNTHESIS, FORMATION OF NANOSTRUCTURES, DOCUMENTARIES DECISION, INFORMATION TECHNOLOGY, INFOLOHICHNE MODELING, CARRYING LAYERS TRANSPORT INTERACTION CRITERION SIMILARITY SECURITY RESOURCE SPACE SELF-ORGANIZATION.
RESEARCH ON THE EFFICIENCY OF SMALL PACKAGE DRAINAGE FUNCTIONING IN ROAD CONSTRUCTIONS
Authors:   National Transport University, Kyiv, Ukraine, A Bubela
Published: November 2021

The article proposes and analyzes the types of small drainage drainage for the effective removal of moisture accumulated in road structures. Object of study - drainage systems for drainage of road construction. Purpose of the work is to determine the effectiveness of the road structure under the influence of precipitation and infiltration moisture. To avoid long-term wetting of the pavement layers and the foundation of the road structure, it is necessary to prevent the accumulation of a large amount of free water in them by arranging a drainage system that will quickly drain the water and ensure its strength. The study of the transverse drainage of shallow laying in the experimental installation of the road structure was carried out according to two variants of the drainage structure. Measurements were made of the modulus of deformation, soil moisture, absolute soil moisture content of the soil and the gravel layer of the substrate. After drying the soil over time, the absolute humidity decreases by about 10%, which significantly affects the value of the modulus of deformation, which increases almost 2 times. The results of the article can be implemented in the development of road building standards for the construction of linear objects. KEYWORDS: CAR ROAD, DRAINAGE OF SMALL PAYMENT, CONSTRUCTION, MOISTURE, DEFORMATION MODULE, EARTH FLOOR, COATING BACK, BASE LAYER, EXPERIMENTAL INSTALLATION.
ON THE THEORY OF THE PROCESS OF BORONATION OF IRON-CARBON ALLOYS IN A MAGNETIC FIELD
Authors:   National Transport University, Kyiv, Ukraine, A Duleba , O Melnyk ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The article offers an analysis of the results of the processes of formation of iron borides from the point of view of quantum theory. The object of study is the phase composition, physicomechanical and electrophysical properties of boride, borosilicidal and aluminum-boride coatings on iron and steel. The research method is x-ray and metallographic analysis. Based on the analysis of the results of the formation of iron borides on boron diffusion from the point of view of quantum theory, it was found that a significant increase in the physicomechanical properties of partially microhardness and wear resistance occurs by establishing stable electronic configurations of chemical compounds. So, when creating FeB compounds, boron atoms (2s22p1) form sp3 configurations due to electrons of iron atoms (3d64s2), which have the donor property to form stable d5 configurations. Experimental studies of the properties of chemical compounds that form during diffusion saturation confirm a correlation with their electronic structure, and iron atoms tend to form a strong covalent bond with boron atoms. KEY WORDS: BORING, BOROSILICATION, ATOMS, ENERGY LEVELS, QUANTUM NUMBERS, ELECTRON CONFIGURATION.
HISTORICAL AND LEGAL ASPECTS OF REGULATING INTERNATIONAL MOTOR TRANSPORTATION
Authors:   National University of Water and Environmental Engineering, Rivne, Ukraine, O Kirichok , V Antoniuk ,   Rivne Motor Transport College of National University of Water and Environmental Engineering, Rivne, Ukraine, O Shevchenko ,   Rivne Motor Transport College of National University of Water and Environmental Engineering, Rivne
Published: November 2021

The article analyzes the basic legal aspects of one of the institutes of transport law - international freight road transport. The article focused on historical and legal aspects, of freight transport by road in international transport legal framework. The main directions and its systematization are provided in the article. The legal relations that arise during the international carriage of goods by road and which are drawn up by the relevant civil agreements are describes, the basic rights and obligations of the parties in these relations are detailed. Object of study - international road freight transport. The purpose of the work is to propose ways to improve the organization of the international road haulage system, to reveal the role of state bodies in ensuring its effective functioning in accordance with the legislation of Ukraine. Method Research - a multivariate analysis of the research object's operating conditions. In all countries of the world, transport is one of the important sectors of the economy and an integral part of interpersonal relations. The transportation process does not produce a new product, but acts as a link between enterprises, facilitating the functioning of other sectors of the economy, the fulfillment of social tasks, the rational and flexible use of productive forces, ensuring the country's defense capability. Therefore, the state policy of Ukrainian transport complex formation and development provides for timely, complete and qualitative satisfaction of the needs of public production and economic entities in international freight transportation, creation of equal conditions for the development of economic activity of road transport enterprises of all forms of ownership and entry of Ukrainian transport complex to the European and the world transport system The results of the article can be implemented in the work of motor transport enterprises that provide international freight. Estimated assumptions for the study object development - the search for the optimal system organization of international road haulage. KEYWORDS: INTERNATIONAL ROAD TRANSPORTATION, CARGO, CONVENTIONS, AGREEMENTS, CONTRACTS, CARRIER, FREIHGHT FORVARDER, CARGO RECEIVER, CARRIER VEHICLE
ANGULAR DEPENDENCE OF TWO-PHOTON ABSORPTION IN CdP2
Authors:   National Transport University, Kyiv, Ukraine, M Malysh , N Kulish ,   V. Lashkaryov Institute of Semiconductor Physics, NAS of Ukraine, Kyiv, Ukraine
Published: November 2021

In CdP2 linearly circular dichroism and frequency dependence of the two-photon absorption coefficient р have been studied in detail, however, we do not know the value of the absolute value of в and its dependence on polarization azimuth. Purpose of research: testing of possibilities of direct method of measuring the coefficient of two- photon absorption in solids. Object of research - monorcycles CdP2. The research method is experimental. The angular dependence of the two-photon absorption coefficient CdP2 and the intensity of light at the sample output is established. When designing and manufacturing elements of power optics and correlators from univalent crystals, one must take into account the following dependencies. KEYWORDS: POLARIZATION, TWO-PHOTON ABSORPTION, CdP2, POLARIZATION AZIMUTH
ORGANIZATION OF THE INTERCEPTING PARKING LOTS («PARK & RIDE» PARKING SYSTEM) IN KYIV
Authors:   National Transport University, Kyiv, Ukraine, V Polishchuk , S Yanishevskyi ,   National Transport University, Kyiv, Ukraine, O Humeniuk ,   National Transport University, Kyiv, Ukraine
Published: November 2021

The paper identifies the main problems with parking in Kiev and their causes, analyzes the European experience in organizing a parking system according to the Park & Ride principle, identifies the main goals and principles for designing the intercepting parking for the implementation of this system, and also studies the feasibility of such car parks in Kiev (an experiment to determine the total time spent by passengersresidents of Boyarka when they move in the morning «peak» periods to the central part of Kiev). Object of the study – the general methodological provisions for organizing intercepting parking (Park & Ride systems) and organizing combined trips (individual and public transport) using the intercepting parking at the «Ipodrom» metro station (Glushkov Avenue) in Kiev. Subject of the study – the process of moving passengers-residents of the Boyarka city in the morning periods of «peak» in the central part of the city of Kiev. As shown by the results of the experiment, the use of public transport (metro) to travel around Kiev as an alternative to individual transport allows passengers to reduce time and, more importantly, significantly increase the guarantee of timeliness of travel. In addition, moving along the route of the Boyarka – Kyiv city according to a combined scheme (using public transport when driving around the city, regardless of the area of location), will be economically advantageous. The organization in Kiev of a network of intercepting car parks at the end stations of metro lines («Teremki», «Lisova», «Chervony Khutir» and «Syrets») in combination with other measures (for example, restricting parking on the streets in the city center, introducing parking throughout the city center, a reliable metro network, as well as an improved view / supply of public transport services) will help to reduce the flow of individual cars on the radial trunk streets and in the center of Kiev. KEYWORDS: PARKING SYSTEM, CENTRAL PART, INTERCEPTIVE PARKING, PARK & RIDE SYSTEM, INDIVIDUAL CAR, PUBLIC TRANSPORT, COMBINED TRIP, TIME COSTS
ANALYSIS OF THE IMPACT OF ROAD SAFETY BARRIERS ON REDUCING THE RISK OF DANGEROUS ROAD ACCIDENTS AND THEIR CONSEQUENCES
Authors:   National Transport University, Kyiv, Ukraine, D Savostin-Kosiak , Jacek Michalski ,   Rzeszow University of Technology, Rzeszow, Poland
Published: November 2021

The weaknesses of the road systems were analyzed, including dangerous events generated by vehicle getting out of the road and consequent secondary dangerous events such as: driving over a barrier or other dangerous object located next to road or roofing of the vehicle. Particularly, the security, availability of technological solutions for protection barriers, columns and road signs on roads and bridges were considered. The preventive and protective functions of road equipment and engineering objects are given, which are adequate to the specific risk. Failures of safety barriers and road protection barriers and the consequences of their failures for people, properties and the environment were analyzed. Solutions for the construction of road barriers were analyzed in terms of: availability, the degree of reliability of their components and the possibility of maintaining risk within acceptable limits. The scope of fulfillment of required functional features, design methods, modern technological solutions, test methods and certification procedures were analyzed. Functional features of protective barriers regarding: the protection level, displacements and the level of impact intensity were taken into account. Literature point of view on aided design of protective barriers has been included which covers finite element method (method of sum of displacements) with appropriate analysis of forces, torques and displacements with CAD systems including use of LS-DYNA system for events and damage parameters. A large part of the publication deals with modern technological solutions and analyzes including design of protective barriers, modeling of their elements as well as modeling collisions with vehicles, taking into account the impact of the ground. KEYWORDS: PROTECTION BARRIERS, FAILURES OF PROTECTION BARRIERS, DESIGN METHODS, SECURITY OF PROTECTION BARRIERS