bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical characterization of pulp components in unbleached softwood kraft fibers recycled with the assistance of laccase/HBT system
Authors: da Silva Thiago Alessandre , Mocchiutti Paulina , Zanuttini Miguel A. , Ramos Luiz Pereira
Published: July 2023

Oxidative treatments, without and with assistance of a Laccase-Mediator System (LMS), were characterized in relation to their effects on the chemical composition and strength properties of the fibrous fraction of an unbleached recycled softwood kraft pulp. The LMS, composed of a Trametes hirsuta laccase extract and 1-hydroxybenzotriazole (HBT), was applied on the fibrous fraction of a recycled pulp at low consistency under continuous stirring and oxygen bubbling. Control treatments adding neither the enzyme nor the mediator were also considered. The LMS treatment caused a partial reversion of the detrimental effects of hornification. A considerable increase in the amount of carbonyl groups on the lignin structure was observed as a result of the enzyme treatment. The amount of extractives in ethanol:toluene also increased after the enzymatic treatment, and the dioxane-soluble kraft lignin underwent a noticeable decrease in its apparent molecular mass. This latter effect was readily attributed to the hydrolysis of aryl-ether bonds that survived the severity employed in the pulping process. These observations were useful to explain why LMS-recycled fibers produce handsheets with 9.4% better tensile strength than the control pulps.
Bio-modification of eucalyptus chemithermo-mechanical pulp with different white-rot fungi
Authors: Yang Qifeng , Zhan Huaiyu , Wang Shuangfei , Fu Shiyu , Li Kecheng
Published: July 2023

Modification of chemithermomechanical pulp (CTMP) by fungal treatment was investigated. Eucalyptus CTMP was treated with three different types of white-rot fungi, namely, Phanerochaete chrysosporium (P.c-1767), Trametes hirsute 19-6 (T.h-19-6), and Trametes hirsute19-6w (T.h-19-6w), under a stationary culture condition. Pulp total weight loss, lignin loss, and cellulose loss were determined to compare the different enzymes secreted by the three fungal strains. Pulp physical strengths, optical properties, and bleachability after the fungal treatment were investigated to compare the effect of fungal treatment on the pulp quality improvement. The results show that lignin reduction by both T.h-19-6 and T.h-19-6 (w) was about twice as much as that by P.c-1767. However, the selectivity of T.h-19-6 (w) towards lignin over cellulose was only 0.82, while that of T.h-19-6 was as high as 4.43. After T.h-19-6 treatment, pulp tensile, tear, and internal bonding strength increased by about 27%, 38%, and 40%, respectively.
Parent-Reported Clinical Utility of Pediatric Genomic Sequencing
Authors: Smith Hadley Stevens , Ferket Bart S. , Gelb Bruce D. , Hindorff Lucia , Ferar Kathleen D. , Norton Mary E. , Sahin-Hodoglugil Nuriye , Slavotinek Anne , Lich Kristen Hasmiller , Berg Jonathan S. , Russell Heidi V.
Published: July 2023

BACKGROUND AND OBJECTIVES

Genomic sequencing (GS) is increasingly used for diagnostic evaluation, yet follow-up care is not well understood. We assessed clinicians’ recommendations after GS, parent-reported follow-up, and actions parents initiated in response to learning their child’s GS results.

METHODS

We surveyed parents of children who received GS through the Clinical Sequencing Evidence Generating Research consortium ∼5 to 7 months after return of results. We compared the proportion of parents who reported discussing their child’s result with a clinician, clinicians’ recommendations, and parents’ follow-up actions by GS result type using χ2 tests.

RESULTS

A total of 1188 respondents completed survey measures on recommended medical actions (n = 1187) and/or parent-initiated actions (n = 913). Most parents who completed recommended medical actions questions (n = 833, 70.3%) reported having discussed their child’s GS results with clinicians. Clinicians made recommendations to change current care for patients with positive GS results (n = 79, 39.1%) more frequently than for those with inconclusive (n = 31, 12.4%) or negative results (n = 44, 11.9%; P < .001). Many parents discussed (n = 152 completed, n = 135 planned) implications of GS results for future pregnancies with a clinician. Aside from clinical recommendations, 13.0% (n = 119) of parents initiated changes to their child’s health or lifestyle.

CONCLUSIONS

In diverse pediatric clinical contexts, GS results can lead to recommendations for follow-up care, but they likely do not prompt large increases in the quantity of care received.
THE CONCENTRATION OF HEAVY METALS IN MARINE WATERS FROM PHU YEN TO BEN TRE
Authors: Vinh Le Thi , Thom Pham Van , Thu Nguyen Hong , Kiem Duong Trong , Tam Pham Huu
Published: July 2023

Data obtained from investigations which have been carried out in the sea from Phu Yen to Ben Tre during 1999 - 2004 indicated that the heavy metal concentrations ranged from 1.3 to 23.1 μg/1 (mean 9.2 μg/1) for Zn; 0.3 - 5 .9 μg/1 (mean 2.7 μg/1) for Cu; 0.1 - 3.0 μg/1 (mean 1.3 μg/1) for Pb: 0.04- 0.4 μg/1 (mean 0.2 μg/1) for Cd: 0.45 - 5.7 μg/1 (mean 1.9 μg/1) for Cr: and 72.5 - 205.5 μg/1 (mean 121.9 μg/1) for Fe. Some data relating to As, Hg and Ni showed that As ranged from 1.2 to 5.9 μg/1 (mean 1.7 μg/1); Ni: 0.9 - 2.3 μg/1 (mean 1.44 μg/1): Hg: 0.07 - 0.62 μg/1 (mean 0.14 μg/1). Mean concentration of metals Zn, As, Cu were lower than those in Southeastern coastal sea and GulfofThailand, while mean concentration of Pb, Cu, Hg and Cd were similar. According to Vietnamese Standards for aquaculture waters, Zn in some stations exceeded the maximum allowable concentration and Fe exceeded the maximum allowable concentration in almost stations.
STRUCTURAL DYNAMIC OF SEAGRASS COMMUNITIES IN THE PHU QUOC ISLAND (KIEN GIANG PROVINCE)
Authors: Huong Tu Thi Lan
Published: July 2023

Three seagrass species at eight sites in the Phu Quoc island (Kien Giangprovince) were surveyed using the quadrat sampling method in May 2006, September and December 2007. Density, biomass ofthree species and environmental factors were analyzed to determine dynamics and correlation using ANOVA - two factor. ANOVA showed that temperatures, turbidirty, rain fall influence seagrass density as well as biomass. Three seagrass species reached maximum shoot density and biomass in December (dry season) anddecline in May (rainy season). Average total biomass ofseagrasses ranged from 210 DWg/m2 (Enhalus acoroides); 225.52 DWg/m2 (Cymodocea serrulata); 239.23 DWg/m2 (Thalassia hemprichii). Average shoot density ofEnhalus acoroides: 74 shoots/m2; Thalassia hemprichii: 520 shoots/m2; Cymodocea serrulata: 774 shoots/m2.
Efeitos do horário de verão sobre acidentes no Brasil: Uma abordagem de Regressão Descontinua
Authors: Franco Cleiton , Sampaio Gustavo Ramos , Sampaio Breno , Machado Weily Toro
Published: July 2023

O horário de verão é uma política de redução do consumo de energia instituída no Brasil todos os anos a partir da segunda semana de outubro. O presente trabalho tem por objetivo avaliar os possíveis efeitos da política do horário de verão sobre os acidentes nas rodovias federais brasileiras. Os dados de ocorrência de acidentes da polícia rodoviária federal utilizados compreendem o período de 2007 a 2013, agregados por dia e hora para cada Estado brasileiro. Primeiramente foram apreciados os efeitos a curto prazo sobre o número de acidentes na transição de entrada do horário de verão nos estados que sofreram a intervenção, por meio do modelo de Regressão Descontinua. A transição para o horário de verão, aproximadamente os primeiros vinte e quatro dias, reduzem o risco de acidentes nas rodovias federais através da realocação de uma hora de luminosidade da manhã para a tarde. Logo após foi mensurada a duração do efeito da mesma política a longo prazoem todos os estados, por meio do modelo de Diferenças em Diferenças. Ambos os modelos revelaram que a aplicação da política do horário de verão apresentou evidências na redução sobre o número de acidentes nas rodovias federais brasileiras. A fim de complementar a análise, foram realizados testes de robustez que determinaram os efeitos de tendências anteriores, Estados com maior risco de acidentes, decomposição em horas de luminosidade e período final do horário de verão. Os resultados apontaram que os Estados em que a política do horário de verão foi utilizada os acidentes sofreram redução de 10% (dez por cento).
ASSESSING SHEAR STRENGTH OF SILICA-NASH GEOPOLYMER COMPOSITE USING MOLECULAR DYNAMIC SIMULATION
Authors: Ji Koochul , Won Jongmuk
Published: July 2023

Alkali aluminosilicate hydrate (NASH) geopolymer has been utilized as an environmentally friendly binder to replace
conventional cement-based binders for ground improvement. Because shear strength is one of the critical mechanical
properties in assessing the performance of geopolymer-improved soils, this study investigated the shear strength of silica-NASH geopolymer (S-G-S) composite using molecular dynamic simulation to simulate the shear behavior of
geopolymer-improved soils in the molecular scale. The NASH geopolymer was first successfully constructed, which
showed comparable modulus of elasticity to the observed experimental results, followed by adding silica layers to
develop an S-G-S composite using geometry optimization and isobaric-isothermal ensemble simulation. The obtained
interfacial shear strength of the developed S-G-S composite increased as shear velocity increased. In addition, the higher interfacial shear strength of the S-G-S composite than the shear strength of geopolymer-improved soils in literature implies the shear failure of geopolymer-improved soils is unlikely to occur at the soil-geopolymer interface. The framework shown in this study can be used as a reference model to provide molecular-scale insight into the shear behavior of geopolymer-improved soils under the variation of many influencing factors (soil mineralogy, temperature, and alkali activator content).
The potential of mRNA vaccine in HCC treatment
Authors: Rui Han
Published: July 2023

Neoantigen mRNA vaccines are a potential form of immunotherapy for Hepatocellular Carcinoma (HCC). These neoantigens can be targeted with personalized mRNA vaccines, which are designed to stimulate the patient’s immune system to recognize and destroy cancer cells. Neoantigen mRNA vaccines are developed using RNA sequences that are synthesized based on the genetic mutations found in HCC patients. These RNA sequences are formulated into a vaccine and administered to the patient, typically in combination with other cancer treatments for enhancing the anti-cancer effect. Several preclinical and clinical studies have shown promising results for neoantigen mRNA vaccines in HCC immunotherapy. Early results suggest that they may be a valuable addition to the treatment options available for HCC patients. However, more research is needed to determine the safety and efficacy of these vaccines.
Overview of major cutaneous and subcutaneous skin problems in horses and their associated risk factor in and around Bishoftu town
Authors: Alemayo Negera , Soressa Bakala , Bikila Abebe
Published: July 2023

Horses are the most important animals in the packing and transport systems of Ethiopia. Though disease and related problems are significant impediments to their performance, their socioeconomic contribution is frequently undervalued; as a result, their welfare is severely jeopardized. As a result, this cross-sectional study was carried out to identify the major skin problem of working horses in and around Bishoftu town, as well as associated risk factors. A total of 414 working horses were considered for the study. Selected horses were clinically examined for visible skin lesions, and a questionnaire survey was performed simultaneously. The overall prevalence of skin problems was found to be 60%. In decreasing order, the skin problems recorded in the study were wound (41.3%), epizootic lymphangitis (16.4%), and sarcoids (1.9%). There was a significant difference (x2 = 15.66, p 0.05) in the prevalence of wounds among different body condition scores; horses in poor body condition were more exposed to wounds than horses in better body condition. There was a significant difference (p 0.05) in the prevalence of wound up by age group, indicating that horses in their senior years were particularly vulnerable. Injuries caused by an improper harness and saddle design were more prevalent (x2 = 409.93, p = 0.000). A slightly higher proportion of wounds was encountered in the chest area of the body (24%). There was a significant difference (x2 = 4.0028, p 0.05) in the prevalence of epizootic lymphangitis depending on the type of work that indicated that cart horses were more highly affected than pack horses. But there was no significant difference based on age, body condition score, or housing system. There was a significant difference in the prevalence of sarcoids between horses that had been sheltered and those that had not; the non-sheltered horses had a significantly higher prevalence than the sheltered horses. The anatomical distribution of the occurrence of wounds on the horses was found to indicate an association between areas of harnessing, packing, and inappropriate hobbling. This study showed wounds as a major skin problem for working horses in the region. A comprehensive equine health programme should be implemented in order to alleviate the prevailing problem.
ORKÖY ferdi proje uygulamalarının orman köylüsüne sosyoekonomik katkısı (Sakarya Orman Bölge Müdürlüğü örneği)
Authors: UZUN Hamdi , BEKİROĞLU ÖZTÜRK Sultan , KALKAN BALCI Kısmet Kubra
Published: July 2023

Bu çalışmanın amacı, Sakarya Orman Bölge Müdürlüğünde 2002-2016 yılları arasında uygulanan ORKÖY ferdi projelerinin sosyoekonomik katkısının belirlenmesidir. Kocaeli ve Sakarya illerindeki orman köylerinde sosyal nitelikli kredi kullanan 338, ekonomik nitelikli kredi kullanan 228 ve kredi kullanmayan 187 kişiye anket uygulanmıştır. Ekonomik nitelikli kredi kullanan deneklerin güncel durumda kredi konusundaki ortalama net kârı (2017 yılı parasal değeri) 9.411 TL/yıl olup kredi öncesine göre %26,4 artmıştır. Bununla birlikte ekonomik nitelikli kredi kullananlardan ferdi projesi faal olanlar hane gelirine %20 katkı sağlamıştır. Sosyal nitelikli kredi kullananlarda odun tüketimi kredi öncesine göre %14,5 düşerken, ekonomik nitelikli kredilerde %6,3, kredi kullanmayanlarda ise %9,3 oranında düşmüştür. Sosyal nitelikli kredi kullananlarda su ısıtma gideri %71,8, ekonomik nitelikli kredi kullananlarda %5,5 oranlarında düşerken, kredi kullanmayanlarda ise %9,4 artmıştır. Orman suçlarında ise ekonomik nitelikli kredi kullananlarda %76,9, sosyal nitelikli kredi kullananlarda %17,1 ve kredi kullanmayanlarda %56,8 oranlarında düşme saptanmıştır. Deneklerin, sosyal ve ekonomik nitelikli ferdi proje uygulamalarının ormandan usulsüz faydalanmayı, sırasıyla (0-5 puan aralığında) çok fazla (4,03) ve çok (3,67) düzeylerinde azalttığı kanaatinde oldukları görülmüştür.
A Qualitative Study of the Experiences of Obesity, Body Image, and Mental Health of British-Born
Afro-Caribbean Male Students at a West Yorkshire University in England
Authors: Mbabazi Johnson , Nalweyiso Dorothy Irene , MacGregor Fiona , Breckon Jeff , Kunonga Edward , Tolchard Barry , Dawson Rosemary , Teke Jennifer , Bettany-Saltikov Jossette , Kagugube George William , Nnyanzi Lawrence Achilles
Published: July 2023

Obesity, body image, and depression are all biopsychosocial phenomena that are frequently misunderstood across cultures. Body dissatisfaction is a psychological aspect of obesity that has been associated with disordered eating, low self-esteem, and depression. Nevertheless, body image dissatisfaction may affect non-obese individuals too. Those with a positive body image are more likely to participate in physical activity than those with a negative body image. Individuals who are satisfied with their body image are more likely to possess high self-esteem, confidence, and healthy eating habits. Obesity prevention among the black population is increasingly important. This study sought to examine the perceptions and experiences of British-born Afro-Caribbean male students at a West Yorkshire University in England regarding obesity, body image, and mental health. Twelve participants took part in 45-minute semi-structured interviews. The data was transcribed verbatim and analyzed using thematic analysis. Results revealed four major themes: "healthy lifestyle monitoring," "body image attitude," "experiences of attempting to maintain weight," and "reasons for weight change." Clinically obese individuals exhibited dissatisfaction with their body image. Depression was found to be strongly related to dissatisfaction with one's body image. Obesity is stigmatized and associated with low self-esteem in many societies in the United Kingdom, which impacts mental health. Future health promotion programs should teach obese individuals who are dissatisfied with their body image to deal with emotions like shame, guilt, and pride. Furthermore, individuals should adopt healthier eating habits and increase their physical activity, which is a broad strategy to reduce the incidence of obesity.
Modifiable Risk Factor in Acute Lower Respiratory Tract Infection in under 5 Children
Authors: Ahire Nilesh , Dakhane Shripad , Sonawane Ravindra , Patil Suhas , Sonawane Sagar
Published: July 2023

Objective: Acute lower respiratory tract infections are leading cause of morbidity and mortality in under five children in developing countries. Hence presence study was undertaken to study various modifiable risk factor for acute lower respiratory tract infection in under five children. Study Design: Data collected from a observational study of eighty Acute Lower Respiratory Tract Infection (ALRTI) cases of age group from 2 month to 5 year fulfilling WHO criteria of pneumonia to study various modifiable risk factor. Eighty healthy control of same age group also interrogated. Result: The significant modifiable risk factor were parental illiteracy, low socioeconomic status, overcrowding, partial immunization, pre lacteal feed, early weaning, malnutrition, parental smoking, history of respiratory infection in family and rickets. Conclusion: The present study has identified various modifiable risk factors for acute lower respiratory tract infection which can be tackled by effective education of community.
Study of Psychiatric Morbidity among Patients with Chronic Obstructive Pulmonary Disease in a Tertiary Health Care Institute
Authors: Singh Amandeep , Bhirud Mahesh
Published: July 2023

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a lung disease characterized by chronic obstruction of lung airflow that interferes with normal breathing and is not fully reversible. COPD is a progressive airway disease associated with psychological distress Screening the psychiatric disorders in COPD patients will be helpful in better management of the disease by assuring compliance as well as will help to improve quality of life of these patients leading to overall improvement in patients’ health, by helping in starting early psychiatry management whenever necessary. Methods: A single-center, cross-sectional, observational study performed at a tertiary care hospital between august 2016 and June 2018 to study psychiatric morbidity among patients with chronic obstructive pulmonary disease in a tertiary health care institute. A total of 68 clinically stable patients with COPD were screened for psychiatric morbidity by using Mini International Neuropsychiatric Interview (MINI) version 6.0.0. The clinical diagnosis was confirmed using DSM-5 and by qualified psychiatrist of the Department of Psychiatry. Result: Generalized anxiety disorder, Major depressive disorder, major depressive disorder with Anxiety, Panic attack, Phobia and Substance Abuse Disorder was present in 8.8%, 13.2%, 5.9%, 7.4%, 1.5% and 7.4% of study population respectively. Conclusions: We found that patients with COPD had high prevalence of depressive and anxious symptoms. Therefore, screening and treatment of these psychiatric comorbidities in patients with COPD may lead to significant improvements in patients’ quality of life.
Clonal Propagation of Vernonia elaeagnifolia
Authors: Kanimozhi C. , Silviya R. Angelin , Gopu B.
Published: July 2023

As the inclusion of plants in architecture is increasing in the recent years, the need of finding the best propagation techniques for the plants that adds aesthetic value is also increasing. This study focusses on identifying the best diameter of softwood cutting for promoting the propagation of Vernonia which is called as the ‘Curtain Creeper.’ The present investigation was carried out at SRM Urban Farm Centre, SRM Institute of Science and Technology during the period of 2021-2022. The softwood cuttings of Vernonia with three different diameters as 1 to 1.5 cm, 2 to 2.5 cm and 3 to 3.5 cm were taken and propagated under controlled condition by adopting completely randomized design (CRD). In each treatment, ten observations were recorded for different plant growth parameters. Among the different softwood cuttings of Vernonia, the cuttings with 3 to 3.5 cm (T3) diameter recorded highest mean values of stem thickness, stem length, number of roots, root length and leaf branches.
Efficiency of Parametric and Non Parametric Indices as the Indicators of Grain Yield Stability of Bread Wheat (Triticum aestivum L.) Genotypes under Rainfall Conditions
Authors: Bendada H. , Mehanni O. , Louahdi A.N. , Selloum S. , Guemaz S. , Frih B. , Guendouz A.
Published: July 2023

Background: Under rainfall conditions, grain yield stability is one of the most important objectives of breeding programs, especially in diverse environments. Under such conditions, stability analysis offers the best solution for the relative performance of genotypes over environments. The aims of this study are the selection of adapted and stable bread wheat genotypes based on the using of some parametric and non-parametric index. Methods: The experiment was conducted during the four consecutive agricultural seasons (2016/17-2017/18, 2018/19 and 2019/20) at the level of the experimental station of Setif (ITGC). Eight (08) genotypes of bread wheat were tested in this study. To calculate the parametric and non-parametric indices, we use the STABILITYSOFT program. Result: The association between Wricke’s ecovalence (Wi²), the mean variance component (θᵢ) and the Stability variance (σ²ᵢ) indices with the grain yield proved that the best genotypes for growing under these conditions are G1, G2, Hidhab, Arz, Wifak and Ain Abid. In addition, the selection based on the non-parametric index and the combination selection based on highest grain yield with the parametric and non parametric indices proved that the genotypes G1, G2 and Wifak are the more stable and adapted genotypes under semi-arid conditions. In addition, based on the static and dynamic concepts, the parametric indices bi and CVi are related to the dynamic concept, while the other indices are associated with static stability concept. Overall, the results of this study confirmed that the parametric and Non-parametric methods are the suitable tools to identify the most stable bread wheat genotypes at various environmental conditions.
The Effect of Incorporating Date Waste and Saccharomyces Cerevisiae into the Diet of Ouled Djellel Ewes during Early Lactation and Late Lactation
Authors: Benatallah S.A. , Lakhdara N. , Lakhdari K. , Boussaada T. , Kherraze M.E. , Boukhechem S. , Dib A.L.
Published: July 2023

Background: This study aims to determine the effects of supplementary diets with date waste and Saccharomyces cerevisiae on biochemical parameters in Ouled Djellel ewes at early and late lactation. Methods: Thirty pregnant ewes, were divided into 5 groups. All ewes received wheat straw (1Kg),in addition to wheat straw, the control group (33CON) received 500 g of concentrate. The other groups (8.33REB,25REB, 16REB,16REBsc) were fed with a mixture of date waste and concentrate in different proportions,and Saccharomyces cerevisiae at a rate of 2 gr/ewe for the 5th group. Blood samples were collected at the beginning and at the end of lactation to determine biochemical profile by spectrophotometry.Feed analyses were performed according to AOAC standards. Results: Ewes fed the 8.33REB, 25REB, 16.6REB, 16.6REBsc rations had lower serum levels for the majority of biochemical parameters compared to the 33CON control group.The results indicated that serum glucose, aspartate aminotransferase and urea decreased slightly in the groups supplemented with date waste and Saccharomyces cervicea (Pand lt;0.05) whereas,albumin and cholesterol were marginally significant.Therefore, date waste could be distributed, partially to ewes as an alternative to concentrate.
On a discrete boundary value problem in a quarter-plane
Authors: Vasilyev Vladimir B. , Mashinets Anastasia A.
Published: July 2023

We study the solvability of a discrete analogue of a model pseudo-differential equation in a quarter-plane in discrete Sobolev–Slobodetskii spaces. Using a concept of periodic wave factorization for elliptic periodic symbol, we describe solvability conditions for the equation and for a certain boundary value problem related to this equation. In particular, for certain values of the index of periodic wave factorization, a formula for a general solution of the model discrete pseudo-differential equation is obtained, there are some arbitrary functions in the formula. For their unique determination, we introduce certain additional conditions such as a discrete analogues of integral conditions on angle sides. The existence and uniqueness theorem for the stated boundary value problem is proved and a priori estimates for the solution are obtained. A comparison between discrete and continuous solutions for a special choice of discrete objects is also given.
predictors need for complementary interventions using mobile application technology in women with breast cancer
Authors: Dewi Inggriane , Tri Widianti Anggriyana , Fatmawati Ariani , Wulandari Silfia , Indah Sarirudi Tita
Published: July 2023

Background. Some women with breast cancer tend to have psycho-social stress, embarrassment from the disease’s treatment, and difficulty asking for help. Furthermore, several studies indicate limited use of complementary online intervention in mental and spiritual health care, particularly when using mobile-based technologies.

Purpose. This study identifies the key factors that affect the need for mobile-app complementary interventions and the variables affecting them among Indonesian breast cancer patients.

Methods. A cross-sectional survey study with a simple random sampling technique included 112 patients between May and July 2022. The research instrument used is The Quality of Life-Breast Cancer questionnaire, Functional Assessment of Chronic Illness Therapy–Spiritual Well-Being (FACIT-Sp), Palliative Performa Scale Version 2, and The Need for Complementary Interventions using mobile-app technology (NCIM) to measure Predictors of The Need for Complementary Interventions. Meanwhile, multiple linear stepwise regression was used, and the potential multicollinearity effects among NCIM predictive variables were assessed through the collinearity analysis of variable inflation factors.

Results. The mean score of NCIM was 25.17 and ranged from 10 to 40, and multiple regression analysis showed that the psychological and social dimensions of quality of life, as well as Facit-Sp, significantly affected the NCIM. This explains 8.5% of the total variance in the need for Mobile-app Complementary Intervention.

Conclusion. Women with breast cancer have a high need for complementary interventions based on mobile technology. This study can provide the development of complementary intervention using mobile application technology.
Effectiveness of m-health based self-management on self-efficacy in patients with cancer: A systematic review and meta-analysis
Authors: Anakotta Olivya , Rochmawati Erna , Saidi Sanisah Binti
Published: July 2023

Introduction: M-health has been developed and tested through studies in various settings and found was useful for providing knowledge and experience for nurses in cancer care settings. However, none has synthesized the effectiveness of m-health on self-management of patients with cancer. To evaluate the effect of interventions using mobile-based application on patient’s self-management. Outcome measures were patients’ medical adherence, self-efficacy and self-management level and health literacy.

Method: The review is reported in accordance with the guidelines of the PRISMA statement. A systematic was conducted in five databases. Randomized controlled trials and quasi-experimental trial were eligible for inclusion.  

Results: Eight studies were including. There was no significant effect on self-efficacy after interventions using mobile-based applications (SMD = 0.36, CI 95%, [ 0.16, 0.56 ], p < 0.00006). Qualitative synthesis shows that the use of m-health can improve changes in health behavior, health literacy and physical activity.

Conclusion: M-health app interventions may improve self-efficacy in cancer patients. Meanwhile, changes in health behavior in patients can be significantly improved using m-health based self-management. M-health can be integrated into health services for the management of patients with cancer.
Discovering the perceived social benefits of young peoples’ involvement in juvenile sports clubs including sports clubs’ friends and club involvement as perceived by youth members
Authors: Hogan Conor
Published: July 2023

By young people participating in sport they are experiencing many holistic benefits that are not only physical in nature but also beneficial to their social lives. For almost a century and a half young Irish sports participants have had the opportunity to participate in their native team games of hurling, camogie, and Gaelic football. Although volunteer-led and unprofessional sports for young and adult athletes alike, their governing bodies provide young people with an informal yet organised avenue to experience real-life socialisation with their peers and adult leaders. This paper seeks to establish the perceived social benefits of young peoples’ involvement in juvenile sports clubs including sports clubs’ friends and club involvement as perceived by youth members. As a result of this research, it is obvious that the respondents of this study (who identify as females and males only between the ages of 11 and 18 years of age) feel that having fun, being friends, and having respect for teammates are a social benefit. Adopting these practices will also help with sports success. Another notable outcome of this study showed that the young people researched could be good friends and would be dependable for the respondents if required by them in their lives. They felt happy because of the socialisation that they were experiencing as a result of being involved in their sporting clubs and perceived those in their social network enhanced their lives.
Nicotiana protein kinase 1 (NPK1) in sugarcane: effects on plant development and productivity in Oxisol
Authors: Aquino Gisele Silva de , Guerzoni Julia Tufino Silva , Carlos Eduardo Fermino
Published: July 2023

Losses in sugarcane crops due to water deficiencies have been increasing in Brazil and worldwide. NPK1 (Nicotiana protein kinase1) is naturally found in tobacco plants and provides tolerance to cold, heat, and salt stress, with positive results in corn, tobacco, and Arabidopsis. This study aimed to evaluate the development and productivity of transgenic sugarcane with the insertion of the tobacco NPK1 gene. Sugarcane plants cv. RB855536 were genetically transformed with the insertion of the NPK1 gene by biolistic (transgenic event obtained by biolistic) and agrobacteria (transgenic event obtained by Agrobacterium infection). These transgenic sugarcane plants were evaluated in relation to the control (non-genetically transformed sugarcane plants). The growth and productivity of the plants were evaluated in a greenhouse, at four periods: 60, 120, 180, and 270 days after planting (DAP). The measurements recorded included the average number, length, and diameter of the stems, number of green leaves, leaf area, and leaf area index. The fresh stalk mass was evaluated at 270 DAP. The insertion of the gene NPK1 significantly contributed to sugarcane development. There was a significant difference improvement on tillering across all the evaluated periods. At the end of the cycle, plants transformed using the Agrobacterium maintained a higher number of tillers, with 68 % more tillers than the other plants (control and biolistic). The fresh stalk mass was 48 % higher in productivity (than the control and biolistic). Transgenic sugarcane did not show any delay or decrease in growth compared to the conventional non-transformed sugarcane. Therefore, the results suggest that the insertion of the NPK1 gene into sugarcane is a promising alternative for increasing crop productivity
Agronomic biofortification with zinc in hydroponically cultivated lettuce
Authors: Lima Bianca Machado de , Noboa Caio Salvador , Lima Felipe Marques de , Mello Simone da Costa , Purquerio Luis Felipe Villani , Sala Fernando Cesar
Published: July 2023

Lettuce is the most cultivated leafy vegetable in hydroponic systems. The biofortification of lettuce with zinc (Zn) can contribute to relieving nutritional deficiencies in socially vulnerable populations. Biofortification is affordable, easy and fast, even in urban areas. Our objective was to evaluate the effect of Zn concentration in nutrient solutions on the production and agronomic biofortification of lettuce cultivars. The experimental design was completely randomized, in a split-plot design, with four replicates. We tested Zn concentrations of 0.3, 1.0, 1.7 and 2.4 mg L-1 in the hydroponic solution and the cultivars 'Vanda' and 'Saladela'. We evaluated plant diameter, number of leaves, fresh and dry mass of the aerial part and root, a chlorophyll index, Zn content and the accumulation of Zn in leaves and roots. 'Vanda' lettuce had the largest diameter, and 'Saladela' lettuce had the most leaves. The fresh mass of the aerial part was higher in 'Vanda' lettuce. For a Zn concentration of 2.4 mg L-1, the Zn contents of the leaves and roots were 733.3 and 2441 mg kg-1 and the accumulations of Zn in the leaves and roots were 931.66 and 4890 mg plant-1, respectively. Zn content and accumulation were higher in 'Saladela' lettuce. FM, DM did not decrease with increasing Zn concentration in the nutrient solution. Agronomically biofortifying the lettuce produced hydroponically using the nutrient film technique was thus possible
Effect of edapho-climatic conditions on fruit productivity, yield and olive oil quality in olive orchards (Olea europaea L.): case of a semi-arid region
Authors: Mohamed Elhabty , Zehor Ait Yacine , Jamal Aabdousse , Abdelhaq , Boundi , Aziz Hasib
Published: July 2023

The objective of the present work is to evaluate the relationship between the edapho-climatic conditions of the cultivation environment and the variability of olive productivity, yield, and quality of olive oil in orchards of the Moroccan Picholine (PM) population variety (Olea europaea L.). This work was carried out on different agricultural territorial units (agroecosystems) of the Beni Mellal-Khenifra region with a semi-arid climate during four agricultural seasons (2016/2017 to 2019/2020). For this purpose, the relevant agronomic and agro-biochemical parameters were studied, namely the stage of maturity, fruit and olive oil yields and quality indices. The data treatments of the results were performed according to descriptive and affiliated statistics by analysis of variance (ANOVA). We have found significant correlations (according to Pearson's R) between agroecosystems, particularly for weight of crude olives produced per hectare and temperature (R= 0.803), olive yield and humidity (R= 0.654), olive oil yield and temperature (R= 0.837), olive oil richness and humidity (R= -0.622), as well as the qualitative characteristics of the extracted oils, through the levels of free acidity and peroxide value (R = 0.467). These results confirm that in the studied semi-arid environments, the properties of the biotope of the cultivated olive groves, combined with the interannual agroclimatic variability, effectively influence the productivity of the olive trees, the oil production and the chemical and organoleptic quality of the extracted olive oil
Gene Variant Analysis for the Detection of Hemophilia: A Literature Review
Authors: Sumathi N. , Kumari K. Anitha
Published: July 2023

Background::

Proteins act as clotting factors to stop bleeding at the lesion site.
This implies that people with hemophilia tend to bleed longer after an injury and are more
prone to internal bleeding. Depending on the type of hemophilia, individuals with hemophilia
will have lesser amounts of factor VIII or factor IX than people without it.

Objective::

By analyzing the gene variant of hemophilia affected patient we can predict the severity
of disease at earlier stage which helps to avoid further complications.

Methods::

Predicting hemophilia can be achieved through potential technologies like machine
learning. Using these technologies, one can detect and predict the severity of hemophilia, such
as mild, moderate, or severe.

Results::

y comparing the methods used in protein structure analysis, the advantages and limitations
of methods used in protein structure analysis are discussed.

Conclusion::

The best practices in predicting hemophilia are highlighted in this study and particularly
aim at the basic understanding of applying the potential technologies in the prediction
of hemophilia and its severity. This study represents recent research on hemophilia and the use
of different machine learning techniques (MLT) in this area.
Real-World Adherence and Effectiveness of Remote Patient Monitoring Among Medicaid Patients With Diabetes: Retrospective Cohort Study
Authors: Park Sulki , Kum Hye-Chung , Zheng Qi , Lawley Mark A
Published: July 2023

Background

The prevalence of diabetes in the United States is high and increasing, and it is also the most expensive chronic condition in the United States. Self-monitoring of blood glucose or continuous glucose monitoring are potential solutions, but there are barriers to their use. Remote patient monitoring (RPM) with appropriate support has the potential to provide solutions.

Objective

We aim to investigate the adherence of Medicaid patients with diabetes to daily RPM protocols, the relationship between adherence and changes in blood glucose levels, and the impact of daily testing time on blood glucose changes.

Methods

This retrospective cohort study analyzed real-world data from an RPM company that provides services to Texas Medicaid patients with diabetes. Overall, 180 days of blood glucose data from an RPM company were collected to assess transmission rates and blood glucose changes, after the first 30 days of data were excluded due to startup effects. Patients were separated into adherent and nonadherent cohorts, where adherent patients transmitted data on at least 120 of the 150 days. z tests and t tests were performed to compare transmission rates and blood glucose changes between 2 cohorts. In addition, we analyzed blood glucose changes based on their testing time—between 1 AM and 10 AM, 10 AM and 6 PM, and 6 PM and 1 AM.

Results

Mean patient age was 70.5 (SD 11.8) years, with 66.8% (n=255) of them being female, 91.9% (n=351) urban, and 89% (n=340) from south Texas (n=382). The adherent cohort (n=186, 48.7%) had a mean transmission rate of 82.8% before the adherence call and 91.1% after. The nonadherent cohort (n=196, 51.3%) had a mean transmission rate of 45.9% before and 60.2% after. The mean blood glucose levels of the adherent cohort decreased by an average of 9 mg/dL (P=.002) over 5 months. We also found that variability of blood glucose level of the adherent cohort improved 3 mg/dL (P=.03) over the 5-month period. Both cohorts had the majority of their transmissions between 1 AM and 10 AM, with 70.5% and 53.2% for the adherent and nonadherent cohorts, respectively. The adherent cohort had decreasing mean blood glucose levels over 5 months, with the largest decrease during the 6 PM to 1 AM time period (30.9 mg/dL). Variability of blood glucose improved only for those tested from 10 AM to 6 PM, with improvements of 6.9 mg/dL (P=.02). Those in the nonadherent cohort did not report significant changes.

Conclusions

RPM can help manage diabetes in Medicaid clients by improving adherence rates and glycemic control. Adherence calls helped improve adherence rates, but some patients still faced challenges in transmitting blood glucose levels. Nonetheless, RPM has the potential to reduce the risk of adverse outcomes associated with diabetes.
Effective Prediction of Mortality by Heart Disease Among Women in Jordan Using the Chi-Squared Automatic Interaction Detection Model: Retrospective Validation Study (Preprint)
Authors: Bani Hani Salam , Ahmad Muayyad
Published: July 2023

BACKGROUND

Many current studies have claimed that the actual risk of heart disease among women is equal to that in men. Using a large machine learning algorithm (MLA) data set to predict mortality in women, data mining techniques have been used to identify significant aspects of variables that help in identifying the primary causes of mortality within this target category of the population.

OBJECTIVE

This study aims to predict mortality caused by heart disease among women, using an artificial intelligence technique–based MLA.

METHODS

A retrospective design was used to retrieve big data from the electronic health records of 2028 women with heart disease. Data were collected for Jordanian women who were admitted to public health hospitals from 2015 to the end of 2021. We checked the extracted data for noise, consistency issues, and missing values. After categorizing, organizing, and cleaning the extracted data, the redundant data were eliminated.

RESULTS

Out of 9 artificial intelligence models, the Chi-squared Automatic Interaction Detection model had the highest accuracy (93.25%) and area under the curve (0.825) among the build models. The participants were 62.6 (SD 15.4) years old on average. Angina pectoris was the most frequent diagnosis in the women's extracted files (n=1,264,000, 62.3%), followed by congestive heart failure (n=764,000, 37.7%). Age, systolic blood pressure readings with a cutoff value of >187 mm Hg, medical diagnosis (women diagnosed with congestive heart failure were at a higher risk of death [n=31, 16.58%]), pulse pressure with a cutoff value of 98 mm Hg, and oxygen saturation (measured using pulse oximetry) with a cutoff value of 93% were the main predictors for death among women.

CONCLUSIONS

To predict the outcomes in this study, we used big data that were extracted from the clinical variables from the electronic health records. The Chi-squared Automatic Interaction Detection model—an MLA—confirmed the precise identification of the key predictors of cardiovascular mortality among women and can be used as a practical tool for clinical prediction.
Feasibility, acceptability, satisfaction and challenges of a mHealth for community-based COVID-19 screening by community health workers in Rwanda: Insight from the e-ASCov project (Preprint)
Authors: Omorou Abdou Yacoubou , Ndihimye Pacifique , Hoen Bruno , Mutesa Léon , Karame Prosper , Nshimiyimana Ladislas , Galmiche Simon , Mugabo Hassan , Murayire Janvier , Mugisha Muco , Umulisa Marie Michele , Uwera Yvonne , Musanagabanwa Clarisse , Bigirimana Noella , Nsanzimana Sabin , Guillemin Francis , Rwabihama Jean-Paul
Published: July 2023

BACKGROUND

The pyramid-shaped organization of the Rwanda health system makes Community Health Workers (CHWs) central to the community-based management of outbreaks.

OBJECTIVE

This mixed method study explored the feasibility, acceptability, satisfaction and challenges of a mobile health (mHealth) tool for community-based COVID-19 screening in Rwanda.

METHODS

Two urban (Gasabo and Nyarugenge) and two rural (Rusizi and Kirehe) districts participated to the project (smartphone application for COVID-19 screening). A mixed-method approach was used to inform the feasibility (awareness, expectation), acceptability, (use, perceived benefits), satisfaction and challenges of the mHealth intervention. At the end of the project, CHWs were asked to complete a quantitative questionnaire on use and satisfaction of the application. Then, in-depth interviews (IDIs) and Focus Group Discussions (FGDs) were organised with CHWs. Transcripts were content-analysed.

RESULTS

383 CHWs were recruited and trained 378 of whom participated in this study. More than 7,000 registered and 20% referred to a local COVID-19 testing facility. Despite the application was a novel tool, CHWs were well aware of the use of such tool with appropriate expectations. Use, perceived benefit, and satisfaction were very high, although there were differences between urban and rural districts. The application was perceived as a tool to generate information on COVID-19, inform on the status of the pandemic and help curbing the spread of the pandemic in Rwanda. CHWs were satisfied with the application at all stages of its implementation in their districts.

CONCLUSIONS

In this proof-of-concept study, a smartphone application for screening COVID-19 proved useful as mHealth tool to be used by CHWs, with a potential to increase health system efficiency in an epidemic context. It appears important to analyse the context for its generalisation on a country-wide scale, both in the case of an epidemic and in order to take into account certain conditions at the community level.

CLINICALTRIAL

Not registred in clinicaltrials.gov
Rwanda National Ethics Committee (n°752/RNEC/2020)
No-Wait Flowshop Permutation Scheduling Problem : Fire Hawk Optimizer Vs Beluga Whale Optimization Algorithm
Authors: Baihaqi Muhammad Aghniya , Utama Dana Marsetiya
Published: July 2023

No-Wait Flowshop Permutation Scheduling Problem (NWPFSP) is a scheduling problem that states that every job completed on machine n must be processed immediately on the next machine. The NWPFSP problem is an extension of the flowshop problem. This article proposes two new algorithms fire hawk optimization and beluga whale optimization, to solve the NWPFSP problem and minimize makespan. The two new algorithms developed to solve the NWPFSP problem are tested on three different cases. Each algorithm was run 30 times and was compared using an independent sample t-test. The results were also compared with the Campbell Dudek Smtih algorithm. In addition, the effectiveness of the FHO and BWO algorithms was assessed against the CDS algorithm using the Relative Error Percentage (REP) method. The results show that the FHO and BWO algorithms are better at solving NWPFSP problems when compared to the CDS algorithm. However, the BWO algorithm is more recommended in cases with large data because it can provide better results.