bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of Profitability in Indonesian Islamic Banks: Insights on Financial Performance
Authors: Humairah Nadia , Andriansyah Yuli , Badjie Fatou
Published: February 2025

This study examines the factors influencing profitability in Islamic banks in Indonesia, focusing on leverage, firm size, capital adequacy, and liquidity. As Islamic banks operate under Sharia principles that emphasize ethical financial practices and risk-sharing, understanding these determinants is crucial for enhancing financial performance while adhering to regulatory and ethical standards. The study aims to provide insights into how these financial metrics interact to shape profitability, as measured by Return on Assets (ROA). A quantitative research approach was employed, utilizing secondary data from Islamic banks operating between 2007 and 2018. Multiple regression analysis was conducted to assess the relationships between the independent variables—leverage, firm size, capital adequacy, and liquidity—and the dependent variable, ROA. Diagnostic tests were performed to ensure the validity and reliability of the model. The results reveal that leverage and liquidity positively and significantly impact profitability, highlighting their roles in operational expansion and financial stability. Conversely, firm size has a significant negative effect, suggesting that larger institutions face operational inefficiencies. Capital adequacy, while essential for stability, does not directly influence profitability, indicating potential underutilization of capital. These findings align with and extend prior research, emphasizing the unique dynamics of Islamic banking. This study contributes to the understanding of Islamic finance by offering empirical evidence specific to Indonesia, a major market for this sector. The findings underscore the need for efficient resource allocation, robust liquidity management, and strategies to address inefficiencies in larger banks. These insights provide valuable guidance for practitioners and policymakers aiming to optimize financial performance in Islamic banking.
Soluble transferrin receptor and other indicators of iron homeostasis in pre-eclampsia
Authors:   Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russian Federation, Shcherbakov V.I. , Pozdnyakov I.M. ,   Novosibirsk State Medical University, Novosibirsk, Russian Federation, Shirinskayа A.V. ,   Novosibirsk City Clinical Perinatal Center, Novosibirsk, Russian Federation
Published: February 2025

The assessment of iron status in pre-eclampsia (PE) is challenging since its circulation is affected by both pregnancy and the hypoxia and inflammation associated with PE.
Objective. To study the levels of serum transferrin, soluble transferrin receptor, ferritin, serum iron and related molecules to assess iron homeostasis in PE.
Patients and methods. The study included 265 pregnant women. All patients were divided into two groups: pregnant women with PE (n = 185) and healthy women with normal pregnancy (n = 80) – control group. The levels of soluble transferrin receptor, transferrin, ferritin, iron, uric acid and chlorine ions in serum were assessed.
Results. Serum transferrin levels in PE patients did not differ significantly from that in healthy controls. Soluble transferrin receptor in both moderate and severe PE was almost the same as in normal pregnancy. This indicator was elevated in PE combined with mild anemia. Ferritin, serum iron and uric acid levels increased with PE severity.
Conclusion. Soluble TfR is one of the options for iron chelation, regulating its availability to cells and tissues. Ferritin elevation may serve as a marker of increased iron accumulation in tissues on the one hand, inflammation and its release from damaged tissue on the other. The degree of ferritin elevation may be an indicator of PE severity.
Key words: soluble transferrin receptor, iron homeostasis, pre-eclampsia, pregnancy
Evaluation of the efficacy of a combined oral contraceptive containing chlormadinone acetate in the treatment of hyperandrogenic dermopathy and its effect on psycho-emotional health in adolescents
Authors:   Kursk State Medical University, Kursk, Russian Federation, Khuraseva A.B. , Svyatchenko K.S. ,   Medical Center «Zhivitsa+» LLC, Kursk, Russian Federation
Published: February 2025

Objective. To study the therapeutic effects of a combined oral contraceptive (COC) Belara® (ethinylestradiol + chlormadinone acetate) in hyperandrogenic dermopathy in adolescents and the influence of this medication on psycho-emotional health in girls.
Patients and methods. This prospective study included 50 patients aged 16–18 years who had a need for contraception and clinical manifestations of hyperandrogenism: acne, oily seborrhea, and associated psychological discomfort. For contraception and correction of skin disorders, a low-dose monophasic COC Belara® containing 30 mcg ethinylestradiol and 2 mg chlormadinone acetate was prescribed. The patients’ health status was assessed at the beginning of therapy, after 3 and 6 months. The APSEA (Assessment of Psychological and Social Effect of Acne) scale was used to evaluate the impact of acne on girls’ daily life, mood and self-esteem. The Beck Depression Inventory was used to evaluate the psycho-emotional health.
Results. All patients prioritized the therapeutic effect of COC over clinical manifestations of hyperandrogenic dermopathy when choosing a contraceptive method and were motivated for long-term administration of medication to ensure reliable birth control. As a result of therapy, 15 (30%) patients showed positive dynamics of acne correction after 3 months, 32 (64%) patients had clinical recovery and 18 (36%) had persistent improvement after 6 months. Out of 38 girls with oily seborrhea, 15 (39.5%) subjectively noted improvement in hair quality after 3 months, and after 6 months, the problem persisted only in 5 (13.15%) adolescents. According to APSEA scale, the impact of acne on girls’ daily life, mood and self-esteem decreased after successful
treatment. After 6 months of therapy, signs of mild depression persisted in only 7 (14%) patients, moderate – in 1 (2%) patient.
Conclusion. The use of COC containing chlormadinone acetate is not only effective as contraception, but also has a statistically significant therapeutic effect in adolescent girls with clinical manifestations of hyperandrogenism in relation to the correction of acne and oily seborrhea. It helps to improve appearance, reduce the negative impact of acne on quality of life and thereby stabilize the emotional state.
Key words: acne, combined oral contraceptives, chlormadinone acetate, contraception
Giant mucinous ovarian carcinoma weighing 35 kilograms
Authors:   Patrice Lumumba Peoples' Friendship University of Russia (RUDN), Moscow, Russian Federation, Davydov A.I. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Chaniya K.O. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Asanishvili M.M. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Giorgadze M.B. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Lebedeva M.G. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Karpova I.O. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation, Khabarova M.B. ,   S.S.Yudin City Clinical Hospital, Moscow, Russian Federation
Published: February 2025

This article presents a clinical case of a 64-year-old female patient who had not seen a physician for 8 years. The main complaints on admission were dyspnea at rest, sensation of shortness of breath, weakness, forced semi-sitting position. A comprehensive clinical and laboratory examination was performed, which resulted in the diagnosis of a giant ovarian tumor without signs of malignant process. To prevent hypotensive syndrome, as well as to verify the diagnosis (cytology), drainage of the neoplasm was performed under ultrasound guidance with the installation of multi-perforated drainage. During 3 days of follow-up, 33 liters of serous and hemorrhagic discharge of muddy color were passively leaked through the drainage. Cytology report: reactive inflammation. Total hysterectomy with bilateral salpingo-oophorectomy, large omental resection, and peritoneal biopsy were performed. A tumor of 50 × 40 × 42 cm was removed. Body mass index before surgery was 34.5 kg/m2; after surgery – 21.3 kg/m2. Pathology report: mucinous adenocarcinoma without penetration of the ovarian capsule. pT1a, V1, Lv0, Pn0.
Conclusion. Tumors with a mean diameter >40 cm should be classified as extremely giant ovarian tumors. Patients with such tumors require a multidisciplinary approach.
Key words: extremely giant ovarian tumors, mucinous carcinoma, multidisciplinary approach
Media Augmented Reality (AR) Untuk Menstimulasi Kemampuan Membaca Permulaan Pada Anak Usia Dini
Authors: Novianti Rahmah , Pratiwi Niken
Published: February 2025

Early reading skills are one of the important aspects of language development in early childhood. Early reading is the first stage where children learn to recognize letters, sounds, and words simply. This study aims to determine whether media-based augmented reality (AR) can stimulate early reading skills in children. This type of research is a development research using the ADDIE model. The methods used to collect was instruments. The location of the research was at Darul Hikmah Islamic Kindergarten, the research was conducted in August-September 2024. The results of the study showed that the early reading skills were 43%, after the use of AR-based media, children's early reading skills increased to 78%. Based on this, it can be concluded that using media-based AR can improve children's early reading skills. This research implies that teachers can use AR-based media in the learning process.
Analisis Kombinasi Alat Berat pada Pekerjaan Galian Batu As Maindam STA 0+25 Sampai 0+50 (Studi Kasus : Proyek Pembangunan Bendungan Cijurey Paket 1)
Authors: Ardhya Maharani Shinta , Tunggulgeni Ekodjati , Arsita Laksmi Anasya
Published: February 2025

Peningkatan produktivitas merupakan kunci keberhasilan proyek konstruksi. Penelitian ini berfokus pada analisis kombinasi alat berat yang optimal untuk memaksimalkan produktivitas pekerjaan galian batu pada proyek Bendungan Cijurey. Dengan mempertimbangkan faktor-faktor seperti kapasitas alat, waktu siklus, dan efisiensi kerja, penelitian ini mengidentifikasi kombinasi alat yang mampu menghasilkan volume galian terbesar dalam waktu tercepat. Selain itu, penelitian ini juga memperhitungkan biaya operasional dan kepemilikan untuk setiap kombinasi alat. Hasil penelitian menunjukkan bahwa kombinasi dengan pengurangan jumlah dump truck dari 4 menjadi 3, yaitu Rock Drill Breaker 2 Excavator 1 Dump Truck 3, dapat mempertahankan prduktivitas sebesar 50,31 m3/jam dengan durasi pekerjaan tetap 340 jam. Selain itu, kombinasi ini mampu meningkatkan optimasi operasional dan mengurangi biaya operasional dari RP945.227.618,20 menjadi Rp837.206.928,80 dengan selisih penghematan sebesar Rp108.020.689,40 dibandingkan dengan kombinasi alat yang ada saat ini.
Peningkatan Nilai Kepadatan Tanah Lunak yang Dicampur dengan Limbah Pasir Galian C dan Air Laut
Authors: Saputra Asrul , Rokhman  , Rini Retno Puspa , Iqbal  , Jafaruddin Ahmad Januar
Published: February 2025

Penelitian ini bertujuan untuk mengevaluasi pengaruh campuran pasir dan air laut terhadap nilai kepadatan tanah lunak. Tanah lunak yang memiliki daya dukung rendah karena sifatnya yang menyerap air secara berlebihan, maka diperbaiki dengan mencampurkan pasir untuk mengendalikan kadar air. Pengujian dilakukan menggunakan air tawar dan air laut untuk menganalisis perbedaan nilai kepadatan kering maksimum (γdry max) serta kadar air optimum (Wopt). Hasil menunjukkan bahwa penambahan pasir meningkatkan kepadatan tanah, dengan pencampuran optimal pada kisaran 42-45% pasir. Air laut memberikan hasil kepadatan hampir setara dengan air tawar, meskipun terdapat sedikit penurunan dalam nilai berat jenis. Hasil penelitian menunjukkan bahwa variasi campuran pasir meningkatkan kepadatan tanah lunak, sementara air laut memberikan alternatif yang layak untuk mengurangi penggunaan air tawar di daerah pesisir.
Особенности медико-социальной характеристики пациентов трудоспособного возраста с гипертонической болезнью.
Authors:   Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» (Federal State Budgetary Educational Institution of Higher Education named after N. I. Pirogov) of the Ministry of Health of the Russian Federation, Abdrakhmanov A. R. , Buslaeva G. N. ,   Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» (Federal State Budgetary Educational Institution of Higher Education named after N. I. Pirogov) of the Ministry of Health of the Russian Federation, Oprishchenko S. A. ,   Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» (Federal State Budgetary Educational Institution of Higher Education named after N. I. Pirogov) of the Ministry of Health of the Russian Federation, Polunin V. S. ,   Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N. I. Pirogov» (Federal State Budgetary Educational Institution of Higher Education named after N. I. Pirogov) of the Ministry of Health of the Russian Federation
Published: February 2025

Hypertension is the leading disease among diseases of the circulatory system in the Russian Federation and is not only an important medical, but also a socio-economic problem.
The purpose of the study: to study the medical and social characteristics of patients of working age with hypertension.
Materials and methods. A study was conducted of 247 patients aged 30 to 50 years with an established diagnosis of «Hypertension with predominant heart disease without (congestive) heart failure» (hereinafter referred to as hypertension – GB), attached to a territorial polyclinic.
The results of the work. In the observed patients, the diagnosis of GB in most cases was established when contacting a medical organization, in every fourth patient during periodic medical examination, in every sixth during medical examination. The average age of patients was 42.4±5.4 years, more women than men, two thirds of patients with higher education and are satisfied with their financial
situation, three quarters are satisfied with housing conditions, 71.8% of patients are married.
Conclusion. According to the survey, the medical and social characteristics of patients with GB made it possible to form a socio-hygienic portrait of a patient with GB: most of the population is occupied by women, the average age is almost the same for both groups and is 42.4±5.4 years old, who mostly have higher education, are married, are satisfied with their financial situation, housing conditions and morally- the psychological climate in the family, however, 53.6% of patients have bad habits, 66.0% have an average and high cardiovascular risk.
The scope of the results. The use of the analyzed medical and social characteristics of patients of working age with hypertension for the formulation of preventive measures.
Competence-based approach to personnel management in healthcare: historical aspects.
Authors:   Smolensk State Medical University of the Ministry of Health of the Russian Federation, Semchenkov A. V. , Tikhonova N. K. ,   Smolensk State Medical University of the Ministry of Health of the Russian Federation
Published: February 2025

Based on the analysis of publications, historical aspects of the formation and implementation of competency models for personnel management in healthcare are presented.
Purpose: based on an analysis of global experience in applying the competency-based approach in personnel management, to assess the degree of implementation of corporate models of personnel competencies in healthcare.
Materials and methods. An in-depth study of the literature on the development and application of a competency model in management in medical organizations from a historical perspective was carried out. Methods used: historical, analysis.
Results. The introduction of personnel assessment based on soft competencies into healthcare practice in European countries, Canada, and the USA has proven itself to be successful. In Russia, the modern model of managing a medical organization requires a global and dynamic revision. The competency-based approach to personnel management in healthcare has a high level of theoretical development: the methodology of its construction and the regulatory framework. However, the experience of implementing this approach in healthcare, organizing all stages and procedures for working with personnel in conditions of personnel shortages in a specific medical organization,
is in its infancy.
The implementation of a competency-based approach to personnel management in healthcare has a high level of theoretical development: the methodology of its construction and the regulatory framework. Despite the high level of theoretical development, the modern model of managing a medical organization requires a global and dynamic revision. In Russia, the experience of implementing this approach in healthcare, organizing all stages and procedures for working with personnel in conditions of personnel shortages in a specific medical organization, is in the process of formation.
Findings. The methodology for constructing a corporate model of soft competencies of personnel, the algorithm and diagnostic tools for personalized assessment of personnel in a specific medical organization require detailed development.
Artificial intelligence – a new word in nephrology: points of application and perspectives (literature review).
Authors:   Samara State Medical University, Ministry of Health of the Russian Federation, Sedashkina O. A. , Kolsanov A. V. ,   Samara State Medical University, Ministry of Health of the Russian Federation
Published: February 2025

Background. The management of patients with diseases of the urinary system is an extremely urgent task. The main problem is that
diseases of the urinary system are often without obvious specific symptoms until the stage of renal function limitation. In the first place,
among the complaints and clinical manifestations, come non-specific symptoms, such as anemia, bone deformity, cognitive and vascular
disorders and others, complicating the diagnosis of the underlying disease. In such a situation, early timely diagnosis of diseases of the
urinary system organs with the help of anamnestic, hereditary, clinical and laboratory, instrumental and genetic methods is relevant. The
difficulty lies in the shortage of personnel of nephrology service and interpretation of data by other specialists, so all the responsibility
for early detection of kidney diseases falls on district pediatricians, family physicians most closely interacting with the population.
Artificial intelligence (AI) has become a promising tool in the field of health care, and there are works on its application in nephrology
as a physician’s assistant. Аim of the study was to examine the works on the application of artificial intelligence in nephrology.
Materials and methods. An electronic search in PubMed was performed to retrieve articles published from 2014 to 2024 using
the keywords: Artificial intelligence technologies; machine learning; chronic kidney disease. Review, analysis, and systematization of
articles were performed manually. Out of 264 articles, articles (n=64) related to the diagnosis of kidney disease and the conservative
part of nephrology at the interface with AI were the object of the study. Results of the literature review allowed us to conclude that AI
methods are rapidly developing and can be used to create both descriptive and prognostic models of kidney diseases, personalization
of treatment regimens, and classification of images in imaging methods of examination, thus improving the quality of medical care,
interdisciplinary cooperation, obtaining new knowledge and development of science.
Ecological Index and Distribution Patterns of Seagrass in Banda Sea Tourism Park (TWP)
Authors: Rosalina Dwi , Awaluddin Awaluddin , Jamil Khairul , Surachmat Agus , Rombe Katarrina Hesty , Sabilah Anisa Aulia
Published: February 2025

ABSTRACTSeagrass beds have an important role as the main source of primary productivity or organic matter producers, habitat for various biota, nursery grounds, spawning grounds, food sources for rare biota, and support for the diversity of marine biota species, as well as the economic value of seagrass ecosystem services. This study aims to determine the ecological index and distribution pattern of seagrass in the Banda Sea Aquatic Tourism Park (TWP). The method used is a line transect with a quadrant size of 50 cm x 50 cm that is placed perpendicular to the shoreline. The results showed that the seagrass diversity index at the study site consisted of 7 types of seagrass, namely Thalassia hemprichii, Enhalus acoroides, Cymodocea rotundata, Cymodocea serrulata, Halodule uninervis, Halophila ovalis, and Syringodium isoetifilium. The diversity index is categorized as moderate with a value of H' = 0.01-0.05, and a uniformity value of 0.71 has a high uniformity, which means that the number of individual species from one species to another is not much different from a stable environmental condition. The distribution pattern of seagrass with Id 1 is a grouped category. The physicochemical parameters obtained were in accordance with the growth of seagrass life.Keywords: Banda sea, Distribution pattern, Diversity, Dominance, Seagrass, Uniformity
Application of Bandpass Filter Method on Single Channel 2D Seismic Data in Krakatau Waters
Authors: Simanungkalit Fredrich , Manik Henry , Ramdhani Haqqu
Published: February 2025

ABSTRAKSeismik menjadi salah satu metode yang menggunakan akustik kelautan untuk mengetahui struktur di bawah permukaan laut. Penampang seismik hasil akuisisi data biasanya terdapat noise yang merupakan gelombang atau sinyal yang tidak dikehendaki dan harus dibuang dari data utama. Untuk mengidentifikasi noise pada data seismik tersebut, dalam penelitian ini digunakan fungsi FFT atau Fast Fourier Transform. Penelitian ini bertujuan untuk memisahkan sinyal akustik objek dan noise pada data seismik dengan menggunakan fungsi FFT dan metode Bandpass Filter pada data SeismicSingle Channel 2D di Perairan Krakatau. Akuisisi data seismik yang digunakan pada penelitian ini menggunakan peralatan single-channel high resolution Seismic berupa EGG Multi Electrode Sparker dan hidrofon 16 elemen merek EGG sebagai receiver. Pengolahan data seismik dalam bentuk .segy pada penelitian ini menggunakan perangkat lunak Seisee dan Matlab. Frekuensi tepi optimal pada penelitian ini berkisar antara 7 Hz hingga 29 Hz, dan frekuensi 2400 Hz untuk tepi atas. Frekuensi cut-off optimal bergantung pada nilai frekuensi pada tiap trace dengan nilai frekuensi cut-off bawah menggunakan frekuensi pada kisaran 200 Hz hingga 400 Hz dan nilai frekuensi cut-off atas menggunakan frekuensi 1500 Hz. Kata kunci:  Bandpass Filter, FFT, Frekuensi, Noise, Seismik.ABSTRACTSeismic is one method that uses marine acoustics principle to determine the structure below the sea surface. Seismic cross-sections resulting from data acquisition usually contain noise which is an unwanted wave or signal and must be removed from the main data. To identify noise in the seismic data, this study used the Fast Fourier Transform. This study aimed to separate the object's acoustic signal and noise in seismic data by using the FFT function and Bandpass Filter method on single channel 2D seismic data in Krakatau waters. Seismic data acquisition used in this study was a single-channel high resolution seismic form of EGG Multi Electrode Sparker and EGG 16 elements hydrophone as receiver. Seismic data processing in the form of *.segy in this study were Seisee and Matlab software. The optimal edge frequency in this study ranges from 7 Hz to 29 Hz, and the frequency was 2400 Hz for the top edge. The optimal cut-off frequency depends on the frequency value in each trace, with the lower cut-off frequency value using a frequency in the range of 200 Hz to 400 Hz and the upper cut-off frequency value using a frequency of 1500 Hz.Keywords: Bandpass Filter, FFT, Frequency, Noise, Seismic
Salinity Distribution Pattern in Spermonde Waters Using Remote Sensing Data (Copernicus Marine Service) in 2022
Authors: Rosalina Dwi , Suryadi Lalu Penta Febri , Rombe Katarrina Hesty , Leilani Ani , Irwana Irwana , Haris Rangga Bayu Kusuma
Published: February 2025

ABSTRACTSalinity is the total concentration of ions found in water. Salinity is important for the survival of organisms. Almost all marine organisms can only live in areas that have small changes in salinity. The aim of this research is to determine the distribution pattern of salinity in Spermonde waters in 2022 and to find out a comparative picture of the salinity distribution pattern on Kapoposang Island, Samatellu Lompo Island, Kuninggareng Lompo Island and Lanyukang Island in Spermonde waters in 2022. This research was conducted from August to October 2023 in Hasanuddin University Makassar, Makassar City, South Sulawesi Province. Research was conducted at the Indraja Laboratory, Faculty of Marine and Fisheries Sciences. The data used was satellite image data, namely CMEMS satellite image. The pattern of salinity distribution in Spermonde Waters with an average value of 34.04 ppt is the highest salinity in August, and for the average value of salinity distribution of 32.52 ppt is in January. The comparison pattern of salinity distribution in 2022 on Kapoposang Island, Lanyukang Island, and Samatellu Lompo Island has the same average value, namely the lowest January and the highest August, except for Koninggarang Lompo Island the highest average value is in September and the lowest is in January.Keywords: Salinity, Kapoposang Island, Lanyukang Island, Koninggareng Lompo Island, Samatellu Lompo Island
Chlorophyl-a Distribution and Sea Surface Temprature Using Modis Aqua Image Data in Bone Bay Waters
Authors: Rosalina Dwi , Suryadi Lalu Penta Febri , Leilani Ani , Sari Suci Puspita , Mustafa Mustafa , Suleman Yakub , Jamil Khairul , Surachmat Agus , Maharani Maharani
Published: February 2025

ABSTRACTOne of the parameters determining productivity in the sea is chlorophyll-a. The fertility level of chlorophyll-a is closely related to the concentration of chlorophyll-a. The higher the concentration of chlorophyll-a, the higher the water fertility level, conversely, if chlorophyll-a is low, the water fertility level will also be low. One factor influencing growth rate and chlorophyll-a production is temperature. This research aimed to determine the distribution of chlorophyll-a and sea surface temperature based on season in 2022 in the waters of Bone Bay using quantitative descriptive method and geographic information analysis (GIS) procedure in the form of analysis of Aqua MODIS remote sensing image data. The research results showed that the highest distribution of chlorophyll-a occurred in the east season with a concentration of 0.06-2.04 mg/m³, while the lowest distribution of chlorophyll-a occurred in the west season with a concentration of 0.07-1.76 mg/m³. Meanwhile, the highest intensity sea surface temperature distribution occurred in the west season, which was 28.76-37.09 °C and the lowest sea surface temperature distribution fell in the east season, which was 27.13-33.62 °C. Spatial temperature variability and sea surface chlorophyll-a can be used as information about potential areas for fishing grounds.Key words: chlorophyll-a distribution, sea surface temperature, Bone Bay, Aqua MODIS
Pemetaan Habitat Bentik Berbasis Objek Menggunakan Drone Di Perairan Pulau Gili Labak, Sumenep
Authors: Nugroho Adhitya , Nababan Bisma , Panjaitan James Parlindungan , Agus Syamsul Bahri
Published: February 2025

ABSTRAKPemetaan habitat bentik menggunakan drone memiliki kendala terkait kodisi cuaca dan lingkungan, seperti kecepatan angin dan sun glint yang dapat mengganggu pengambilan gambar dan klasifikasi gambar. Penelitian ini bertujuan untuk mengetahui sudut sensor drone yang optimal, waktu penerbangan drone terbaik di lokasi penelitian, serta mengetahui tingkat akurasi algoritma support vector machine menggunakan metode OBIA. Penelitian ini dilaksanakan di perairan Pulau Gili Labak pada bulan Oktober 2022 menggunakan drone DJI Phantom 4. Penelitian ini menerapkan dua sudut sensor 45° dan 90° serta waktu pengambilan pukul 08:00; 09:30; 13:15; 14:45. Klasifikasi citra drone menggunakan metode OBIA menggunkan metode contextual editing pada level 1 (perairan dangkal). Level 2 menggunakan klasifikasi terbimbing menggunakan algoritma klasifikasi machine learning yaitu support vector machine (SVM) dengan input themathic layer dari data lapangan. Klasifikasi habitat bentik dilakukan pada 6 kelas dengan penerapan skala segmentasi 25, 50, 70, 100. Berdasarkan hasil  pengambilan gambar waktu terbaik menerbangkan drone pada pukul 13:15 menggunakan sudut sensor 90º dilokasi penelitian, diperoleh nilai overall accuracy sebesar 84.06% serta nilai kappa 0.78656 pada skala segmentasi 50 dengan algoritma support vector machine.Kata kunci: pemetaan, habitat bentik, OBIA, drone, Pulau Gili LabakABSTRACTBenthic habitat mapping using drones has constraints related to weather and environmental conditions, such as wind speed and sun glint that can interfere with image capture and image classification. This study aims to determine the optimal drone sensor angle, the best drone flight time at the research location, and determine the accuracy of the support vector machine algorithm using the OBIA method. This research was conducted in the waters of Gili Labak Island in October 2022 using a DJI Phantom 4 drone. This research applied two sensor angles of 45° and 90° and the capture time at 08:00; 09:30; 13:15; 14:45. Classification of drone imagery using the OBIA method utilizes contextual editing at level 1 (shallow water). Level 2 uses guided classification using a machine learning classification algorithm, namely support vector machine (SVM) with themathic layer input from field data. Benthic habitat classification was performed on 6 classes with the application of segmentation scales of 25, 50, 70, 100. Based on the results of taking pictures of the best time to fly the drone at 13:15 using a 90º sensor angle at the research location, an overall accuracy value of 84.06% was obtained and a kappa value of 0.78656 on a segmentation scale of 50 with the support vector machine algorithm. Keywords: Mapping, Benthic Habitats, OBIA, Gili Labak Island
Efectividad de las pausas activas en el Síndrome de Burnout del profesional de enfermería en un hospital de Lima: Estudio pre y post
Authors:   , Primo Diaz Lucero del Carmen , Cueto Landeo Marlega
Published: February 2025

Introducción: El 25% y 40 % del profesional de enfermería que labora en hospitales de Lima presenta síndrome de burnout (SB), experimentando problemas físicos, psicosociales y deficiencia laboral. El objetivo de la investigación fue; evaluar la efectividad de las pausas activas en el síndrome de burnout que presenta el profesional de enfermería en un hospital de Lima. Materiales y Métodos: Se realizó un estudio de enfoque cuantitativo, diseño cuasi experimental de corte longitudinal. La recolección de datos fue a través de una encuesta aplicado a una muestra de 78 profesionales de enfermería en un hospital de Lima divididos en grupo experimental y de control. La variable pausas activas se midió a través de sesiones de aprendizaje mientras que para la variable de síndrome de burnout se hizo uso del cuestionario de Maslach Burnout Inventory. Resultados: El sexo que predomina son las mujeres con 80,8%, con una edad media de 35.9 años, el 46% son solteros. El promedio de SB en el pre - test fue de 62,9 y post - test de 31,9 obteniendo una diferencia entre medias de 30,6%. Conclusión: Las pausas activas son efectivas para mitigar el burnout en este grupo profesional.
Revisión bibliométrica de publicaciones sobre rehabilitación respiratoria en adultos con COVID-19
Authors:   , Valencia Borda Miguel Angel , Huaman Marin Caroline Sheyla
Published: February 2025

Antecedentes: El Covid-19 es causado por una nueva cepa de coronavirus denominado SARS-CoV-2 que tiene gran mortalidad y múltiples secuelas a corto, medio y largo plazo afectando en la calidad de vida, que han hecho necesaria la instauración de terapia respiratoria en estos pacientes, posterior a los años de la pandemia por este virus. Materiales y métodos: Estudio descriptivo con un enfoque bibliométrico, basándose en la revisión de artículos científicos sobre rehabilitación respiratoria en adultos con Covid-19, publicados en la base de datos de SCOPUS hasta noviembre de 2023. Resultados: Se obtuvieron 223 artículos, en su mayoría fueron artículos originales y publicados en el idioma inglés. El país con mayor producción científica relacionado al tema en mención fue Italia y la mayor producción por autor fue de 4 artículos. Conclusiones: Desde el inicio de la pandemia, se ha observado un notable incremento en el volumen investigaciones publicadas relacionadas del tema. Manteniendo cierto número por su importancia en la salud pública y la carga de la enfermedad en la actualidad. Estos estudios han sido desarrollados por instituciones que han generado precedente del manejo secuelar respiratorio de COVID-19 desde su aparición en estos últimos años.
Implementación de un servicio de tecnología IOT Y RFID en la gestión logística en el área de almacén de la empresa CONSORCIO FENIX SERVICIOS GENERALES S.A.C del distrito de Chilca - Cañete 2022
Authors:   , Castillo Llantoy Jose Armando , Jaules Mauro Josue Quri
Published: February 2025

El objetivo del estudio se orientó en conocer el impacto que tiene la tecnología IoT y RFID a la gestión logística en el área de almacén de la empresa Consorcio Fénix Servicios Generales S.A.C. durante el periodo comprendido del 2022 al 2024. Para este fin, se consideró una muestra de 100 herramientas, el diseño de investigación cuasi experimental, de tipo aplicada y con un enfoque cuantitativo. La mejora del flujo de inventario fue del 15% posterior a la implementación. Además, la rentabilidad de los proyectos realizados por la empresa aumentó en un 8%, mientras que la toma de decisiones basadas en datos aumentó en un 9%. Así mismo, se registró un aumento en la seguridad, que fue seis veces mayor. Por lo tanto, se infiere que la implementación de la tecnología IoT y RFID mejoró significativamente a la gestión logística.
Aggregation Behavior of Asphaltenes in Heavy Oil and Its Influencing Factors: A Multiscale Study Based on Molecular Dynamics Simulations and Quantum Chemical Calculations
Authors: Han Yuxiao , Fu Jian , Deng Shuyuan , Zhang Cenqian , Wang Bo , Gao Jie , Zhang Fan , She Yuehui
Published: February 2025

Asphaltenes and resins are important and complex components of heavy oils, and their self-aggregation behavior has a profound effect on the oil and gas industry. In this study, based on three classical molecular models of asphaltenes, the aggregation laws of asphaltenes with different structures and their influencing factors were investigated using molecular dynamics (MD) simulations and quantum chemical calculations. By analyzing the equilibrium conformations, interaction energy, radial distribution functions (RDFs), mean square displacements (MSDs), diffusion coefficients, cluster analyses, radii of gyration, electrostatic potentials, and nonbonding interactions, we found that archipelago-type asphaltenes have the strongest interactions, the highest probability of occurrence, and the best stability. In contrast, continental asphaltenes have the strongest diffusion ability in the heavy oil model. Quantum chemical calculations show that the asphaltene association is mainly driven by van der Waals forces initiated by the aromatic core and electrostatic attraction around the heteroatoms, whereas the aggregation behavior is influenced by a variety of factors, such as intermolecular van der Waals forces, hydrogen bonding, and π-π interactions. In addition, external conditions, such as temperature and pressure, considerably affect the aggregation behavior of asphaltenes. This study provides a theoretical basis for exploring the viscosity mechanism of heavy oils and scientific support for the efficient development of oil and gas fields.
The Effect of Gender on Stress Coping Strategies in University Students
Authors: Adams Sherifdeen
Published: February 2025

Introduction: Over the past years, stress among university students has always remained a subject of attention for academics since it affects not only their academic performance but also their physical and psychological fitness. Male and female students observe and respond to stressors inversely as a result of their dissimilarities in assessing stressful circumstances.
Aims: The study sought to examine the effect of gender on stress-coping strategies in university students.
Methods: The study adopted a cross-sectional design. The Stress Coping Inventory Style (SCSI) was used to ascertain the type of coping strategies used by students when confronted with academic stress. A total of twenty-eight (28) questions were administered to ninety (90) students at the University of South Wales. Data were analyzed using SPSS, with results presented using the Multivariate Analysis of Variance (MANOVA) to determine the statistical significance difference between variables and the level of analysis in this study was the individual given that groups were being compared based on gender. Statistical significance was set at 0.05, with 95% confidence intervals assessed.
Results: The study found that there was a statistical difference between females and males on stress coping strategies. “F(4,85) = 2.63, p=0.04; Wilks’ λ = 0.890”.
Conclusion: Gender has a significant effect on stress-coping strategies in university students.
JTC801 regresses uveal melanoma progression through novel methuosis-like cell death via lysosomal dysfunction
Authors: Liu Qiuyan , Huang Mingyan , Ji Xinpei , Zhu Ha , Chang Wenjun , Shen Hao , Yu Yizhi
Published: February 2025

Uveal melanoma (UM) is the most frequent primary intraocular malignancy in adults with high metastasis and mortality rate, whose effective therapeutic strategy is still in urgent need. Specifically, apoptosis-resistance is a great challenge for advanced UM patients, therefore novel therapeutic options targeting otherwise death modality, which may potentially enhance treatment effect, need to be further identified. Here, by a kinase inhibitor library of 113 approved drugs screening, JTC801, a selective antagonist of nociceptin receptor (NOP), exhibits a specifically strong tumor-killing ability in a lower dosage. JTC801 induces UM cell methuosis-like death characterized by cytoplasmic vacuolization, markedly regresses tumor progression and metastasis, prolongs the survival in multiple UM tumor models without apparent adverse effects. Mechanistically, JTC801-caused nutrient-deficient stress by mitochondrial damage which triggers macropinocytosis and cytoplasmic vacuolization in UM cells. Concomitantly, JTC801 is trapped into the macropinosomes that fuse with lysosomes, further causing lysosomal over-acidification, de-glycosylation of lysosomal associated membrane protein 1(LAMP1), inhibiting cathepsinsmaturation, and exacerbating lysosomal membrane permeabilization (LMP), eventually inducing UM cell methuosis-like death. Collectively, our findings identify JTC801 as a potential valuable antitumor drug especially for apoptosis-resistant advanced UM patients, and provide insight into the distinct tumor cytotoxicity role of JTC801 in UM treatment.
Results of a Pilot Trial of Infusion Rate Escalation During Convection Enhanced Delivery of Topotecan with a Multiport Catheter
Authors: Liu James K. C. , Tran Nam , Piteo Cecily , Peinhardt Alisa , Vogelbaum Michael A.
Published: February 2025

Purpose: Volume of distribution (Vd) during convection enhanced delivery is impacted by the physical characteristics of the tissue being treated. For Glioblastoma (GBM), Vd is substantially higher in non-contrast enhancing tumor than in contrast enhancing tumor due to higher infusate efflux in enhancing tumor. We hypothesized that increasing the infusion rate could overcome the infusate efflux rate in enhancing tumor to improve the Vd to volume of infusion (Vi) ratio and provide better tumor coverage.
Methods: A single center, IRB-approved pilot study was conducted to perform rate escalated delivery of Topotecan with Gadolinium-DTPA to contrast-enhancing recurrent high-grade glioma. A single Cleveland Multiport Catheter was surgically placed into enhancing tumor and then a 4-hour infusion was performed with real-time MRI visualization. Intra- and inter-patient rate escalation was performed.
Results: Three patients with rGBM were enrolled and treated. The initial infusion rate for patient 1 was 5 microliters/minute per microcatheter (4 total) and the final infusion rate for the third patient was 20 microliters/minute per microcatheter. We observed partial backflow at this rate and so did not escalate higher. There was coverage of both enhancing and non-enhancing tumor in all cases, and the Vd/Vi ratio ranged from 0.7 to 1.3. Patients tolerated the treatments well; there were no CTCAE Grade 3 or higher treatment related adverse events. The higher efflux rate associate with contrast-enhancing tumor tissue can be overcome with sufficient infusion rate escalation.
Conclusion: Increasing the rate of infusion can allow for larger volume of distribution into enhancing tumor tissue.
Adaptation of a neutron radiography instrument for live cell irradiation
Authors: Howell Nicholas , Sierro Frederic , Jarrah Raya , Dobie Christopher , Bevitt Joseph J. , Garbe Ulf , Jakubowski Klaudiusz , Safavi-Naeini Mitra
Published: February 2025

Neutron Capture Therapy (NCT) for cancer treatment is experiencing renewed interest due to advancements in accelerator-based neutron beams, treatment planning software, and patient positioning devices. This study presents the repurposing of an existing neutron radiography beamline (Dingo), at the OPAL research nuclear reactor, for radiobiological research and novel NCT development. Human glioblastoma cell cultures were irradiated for up to 10 mins with a flux of 2.57x108 n/cm2⋅s (± 2.73x107) and the resulting impact was quantified by assessing DNA damage by both immunocytochemistry and flow cytometry. This low cost methodology extends the capability of an existing beamline to allow the development of novel neutron capture agents and study of neutron radiobiological mechanisms. Increasing availability of neutron sources for biological study in this fashion will accelerate the development of NCT for disease specific clinical application.
A Reconfigurable Piezo-Ionotropic Polymer Membrane for Sustainable Multi-Resonance Acoustic Sensing
Authors: Kim Do Hwan , Ying Wu Bin , Kim Joo Sung , YU zhe , Kong Zhengyang , Boahen Elvis K. , Li Fenglong , Chen Chao , Tian Ying , Choi Hanbin , Lee Jung-Yong , Zhu Jin
Published: February 2025

Sensorineural hearing loss is the most common form of deafness, typically resulting from the loss of sensory cells on the basilar membrane, which cannot regenerate and thus lose sensitivity to sound vibrations. Here, we report a reconfigurable piezo-ionotropic polymer membrane engineered for biomimetic sustainable multi-resonance acoustic sensing, offering exceptional sensitivity (530 kPa⁻¹) and broadband frequency discrimination (20 to 3300 Hz) while remaining resistant to "dying." The acoustic sensing capability is driven by an ion hitching-in cage effect intrinsic to the ion gel combined with fluorinated polyurethane. In this platform, the engineered ionotropic polymer stretches under acoustic vibrations, allowing cations to penetrate the widened hard segments and engage in strong ion-dipole interactions (cation···F), thereby restricting ion flux and amplifying impedance changes. Additionally, the sensor’s sustainability is ensured through its self-healing properties and hydrophobic components, which enable effective self-repair in both conventional and aqueous environments without ion leakage, achieving a room-temperature healing speed of 0.3–0.4 µm/min. Leveraging this newly developed sustainable acoustic sensing technology, our devices demonstrate high proficiency in identifying specific sounds in everyday environments (e.g., human voices, piano notes), underscoring their potential as artificial basilar membranes.
The effect of circulating proteins and their role in mediating adiposity’s effect on endometrioid and non-endometrioid endometrial cancer risk: Mendelian randomisation and colocalization analyses
Authors: Wang Sabrina E , Tan Vanessa Y , Yarmolinsky James , Zheng Yadi , O’Mara Tracy A , Timpson Nicholas J , Gunter Marc J , Dossus Laure , Lee Matthew A
Published: February 2025

Background: Proteomics could enhance our understanding of endometrial carcinogenesis. However, addressing confounding in traditional observational studies remains challenging, especially given the strong impact of adiposity on the plasma proteome and endometrial cancer risk. The role of circulating proteins in mediating adiposity’s effect on endometrial cancer risk is also not fully elucidated.
Methods: Using Mendelian randomization (MR) and colocalization analyses, we examined the causal association between 2,751 unique proteins from UK Biobank (N Olink proteins=2,031; N=52,363) and deCODE (N SomaScan proteins=1,667; N=35,559) and endometrial cancer risk [overall (N cases=12,270; N controls=46,126), endometrioid (N cases=8,758), and non-endometrioid (N cases=1,230) in the meta-analysed Endometrial Cancer Association Consortium and Epidemiology of Endometrial Cancer Consortium data]. We performed enrichment analyses to explore pathways overrepresented among plasma proteins in endometrioid and non-endometrioid cancer subtypes. Additionally, we assessed the role of circulating proteins in mediating the effect of body mass index (BMI) on endometrial cancer risk using univariable and multivariable MR.
Results: We identified 20 associations between circulating proteins and endometrial cancer risk in MR and colocalization analyses. GSTO1-1 and SKAP1 were positively associated and MMP10 was negatively associated with both overall and endometrioid endometrial cancer; DTYMK and ABO were positively associated and TSSC4 was negatively associated with overall endometrial cancer; IGF2R was positively associated with endometrioid cancer; MAPK9 was positively associated and DNAJB14, IFI16, LCN2, and SCT were negatively associated with non-endometrioid endometrial cancer. Distinct pathways were overrepresented in endometrioid (e.g., PDGF signalling and PTEN gene regulation) and non-endometrioid (e.g., non-canonical NF-kB signalling) cancer subtypes. GSTO1-1 and IGF2R were identified as potential mediators for the effect of BMI on endometrioid cancer risk in univariable MR, but evidence for mediation was not observed in multivariable MR analyses.
Conclusions: We observed distinct plasma proteins and pathways associated with endometrioid and non-endometrioid endometrial cancers. These findings highlight candidate proteins for further mechanistic investigations, which could support the development of non-invasive methods to differentiate endometrial cancer subtypes and guide clinical intervention strategies. There was limited evidence that the effect of adiposity on endometrial cancer risk was mediated by circulating proteins examined in our study.