bluuebunny/crossref_metadata_2025 huggingface dataset:
تطبيق طريقة العصف الذهني على أساس الذكاء المنطقي الرياضي وأثرها على الكفاءة النحوية لطلاب التخصص الأول بمؤسسة مركز العربية باري كديري/The Implementation of The Brainstorming Method Based on Mathematical-Logical Intelligence and Its Influence on Arabic Grammar Competence in of Takhassus Class Students at Arabic Center Pare Kediri
Authors: Syakur Abd. , Zunairoh Yuyun , Al Akiti Ayman , Iqbal Muhammad
Published: May 2023

Most non-native students regard Nahwu as the most challenging subject. at Markaz Arabiyah, Nahwu teaching still applies a conventional method namely the lecture method and uses a few media. Therefore, the researcher offers an alternative method as a solution to solve the problems. In this case, this research aimed to know the influence of Brain Storming method based on Mathematical-Logical intelligence on student's competence in Nahwu subject. The method of this study is experimental with Quasi-Experimental Design which used Non-equivalent Control Group Design. The population consisting of 30 students of which 14 students are from the control class and 16 students are from the experimental one. The strategy of data collection used in this study consisted of test. The data analysis used a t-test. The result of this study showed that independent data of the T-Test Sample, it could be known that the Significance Value (2-Tailed) is 0,021 < 0,05 which meant that there were significant differences between the average of the experimental class and the control one. The influence and effectivity level of that method is taken from the N Gain Score test which showed 45,19% for the experimental class and 29,73% for the control class. It meant that the Brain Storming method is effective enough, while the conventional one is not effective
Use of Synonymous in The Qur'an (Semantic Analysis Study)
Authors: Al Sayyid Abdul Rahman , Habibi Muhammad Yusuf , Arief Ahmad Fahmy , Husin Saifudin Ahmad
Published: May 2023

In the use of language, sometimes we find a difference between one speech and another speech with expressions that have one meaning. This phenomenon is also called by linguists with synonyms. Synonyms are two words that have one or more meanings, such as "death" and "died". This research aims to: 1. know the analysis of the word forms that are synonymous in Surah Al-Baqarah, 2. Analyze the meaning of rich words that are synonymous in Surah Al-Baqarah. The type of research used in this research is literature research with a qualitative approach. The primary data used are verses containing synonymous words in surah Al-Baqarah. And this research uses content analysis with the krippendorf data analysis model. The results of this research are: there are three forms of synonymous words which include: 1. synonyms inletter form , 2. synonyms in formname, and synonyms in the formfi'il. Adapum means 1. for synonyms inletter formamong them said  "from"can meanli ibtida ghayyah (to begin the purpose), li tab'idh (part),liziyadatil taukid(for amplifier), while the word "on  " can meanthat of (Because), min (from) 2. Tosynonyms in formnameamong them the words "the other daywhich is used to mention the end of world life, while the wordDoomsdayused for the mention of after the end of life in the world, and 3. Forsynonyms in formfi'il for example saidcreationwhich is used for the creation from nothing to exist, while the wordmake  used from there then made into something new. In this study there is something new in that the division of synonym forms is different from the usual types of synonyms, namely: the synonym form consists of isim, fi'il, and letters while the synonym type consists ofat-taraduf al kamil, syibhut taraduf, at-taqaruf ad-dalali, at-tafawuf (fil 'umum, fil special, fil quwwah, Fil malamih)
The Effectiveness of Using Reality Augmented Media to Increase The Students’ Learning Motivation in Chemical Bonding Material
Authors: Nurillah Happy Sagita , Purwanto Kriesna Kharisma , Fatayah Fatayah
Published: May 2023

The purpose of this study was to determine the effectiveness of using Augmented Reality media to increase student learning motivation. This type of research is a quantitative quasi-experimental design with Pretest-Posttest Non-Equivalent Control Group Design. The sample in this study were 42 students in class X-Natural Science and X-Social Science. The research instrument used was a motivational questionnaire with 4 indicators, namely Attention, Relevance, Confidence, Satisfaction (ARCS). Data collection techniques were carried out by giving motivational questionnaires to students before and after learning. The data that has been obtained, then analyzed using the completeness formula of student achievement to determine the level of effectiveness of Augmented Reality media on student learning motivation. The results of the effectiveness of the media in the experimental class and the control class obtained the final motivational completeness percentages of 100% and 86%, respectively. Based on the results of the effectiveness of the media, it can be concluded that the use of Augmented Reality media is stated to be very effective for increasing student motivation in chemical bonding material.
Analysis of ballistic limitations in testing the possibility to establish laser communication with the descending vehicle in the atmospheric descent phase
Authors: Evdokimov R.A. , Gribkov A.S. , Tugaenko V.Yu. , Ovchinnikov A.G.
Published: May 2023

The paper presents the Plasma-SA space experiment to study possibility of establishing a laser communication channel between the descent vehicle of the Soyuz transport spacecraft and ground stations at the atmospheric descent phase, when plasma layer is blocking radio communication. Design limitations associated with safe installation of the scientific equipment onboard the Soyuz spacecraft descent vehicle are briefly considered. Ballistic limitations caused by the descent trajectory and the descent vehicle control at the atmospheric phase determining location areas of the ground-based laser radiation sources were analyzed. Principal possibility to register test signal from the ground source by the equipment installed onboard the descent vehicle is demonstrated. Effect of deviation from the calculated trajectory and of alteration in the roll angle during descent control with its registration is demonstrated, and ways to improve these conditions are proposed.
IMPLICATIONS OF THE DANISH DEFINITENESS ALTERNATION FOR CONCORD IN NANOSYNTAX
Authors: Ross Hayley
Published: May 2023

The Danish definiteness alternation presents two challenges for Nanosyntax. First, it displays structural allomorphy of the definiteness marker between a suffix and prenominal article; second, there is concord between the definiteness marker and noun gender. I show that Nanosyntax can address both issues, explaining the suffix-article alternation by virtue of its spellout algorithm and the lexical overlap between suffix and article. This account provides a deeper explanation for the structural allomorphy than the Distributed Morphology analysis proposed by Hankamer & Mikkelsen (2018). The existing proposal for concord in Nanosyntax (Caha, 2019) cannot handle this combination of gender concord and allomorphy, so I propose a simple copying mechanism which handles concord more flexibly. This new proposal, however, is substantially less restrictive than Caha’s framework, paving the way for future work to balance restrictiveness with empirical coverage of prefix/suffix alternations and concord across languages.
Arctic exploitation issues in the works of the Russian and foreign researchers (XIX-early XX centuries)
Authors: Kyz'yurova N.
Published: May 2023

The Arctic region attracts attention of different states as a potential source of geopolitical influence. The struggle for the resources of the Extreme North is not over - the states are trying to prove their rights to various sections of the Arctic shelf. Therefore, it is important to turn to the experience of previous generations, especially to the development of science in the region according to the changing geopolitical situation, to identify what difficulties the researchers of the past periods faced and how cooperation of states progressed not to harm the fragile environment of the Arctic along the search for new resources. The paper compares the ideas of the Russian and western researchers on the development of science in the Arctic in the XIX and early XX centuries. The study analyzes the sources and literature of the period under study. The paper examines such aspects as the prevailing geopolitical thoughts in the study period - what influenced the appeal specifically to marine resources, the development of Arctic resources - what resources scientists paid attention to, research potential - what tasks were set when studying the region and what difficulties science faced. Common are ideas on the ocean resources development, search for sea passages and the need of natural resources exploitation in the region. Different is realization of thoughts about cooperation and, in general, about development of the Arctic resources.
G.M. Burov - a discoverer and initiator of the Mesolithic studies in the European North-East
Authors: Volokitin A. , Volokitina N. , Rodov S.
Published: May 2023

Grigory M. Burov (22.09.1933 - 24.02.2013), a graduate of the Kiev University, arrived in Syktyvkar in 1957. He worked in the Komi Branch of the Academy of Sciences of the USSR until 1968. Subsequently, he worked in Ulyanovsk and Simferopol.

However, the period of his work in the Komi Region turned out to be the most productive .G.M. Burov is a discoverer of numerous sites of the Mesolithic, Early Metal and Early Iron Age of the previously unexplored Vychegda territory. G.M. Burov analyzed and published materials from Komi all the subsequent years of his life.

The Vis 1 (Mesolithic) and Vis 2 (mid I millennium A.D.) peatbogs discovered by G.M. Burov in the vicinities of the Sindor village have gained worldwide fame. The exemplary paleogeographic studies were carried out in the Sindor microregion. The leading geobotanist and peat specialist S.N. Tyuremnov and other scientists compiled pollen diagrams, described profiles of peatlands, restored the historical courses of the Vis and Simva Rivers. They also obtained a series of direct radiocarbon datings of wooden artifacts.

A unique collection of items made of wood, bark, and grass was obtained at the Vis 1 peatbog. It included fishing tools - fragments of nets and a fishing spear; hunting tools - bows, arrows, a spear; means of transportation - skis, sledge runners, a paddle; household items including a box of birch bark, mats of wood shakes. Many items are decorated with carved geometric ornaments. The sculptural head of an elk on one of the skis is particularly noteworthy.

G.M. Burov was the first of the researchers who justified the cultural differentiation of the Mesolithic sites of the European North-East. He identified two cultural types: the Kama-Pechora type dating back to the VIII-VII millennium B.C., and the Vis type (the second half of the VII-VI millennium B.C.). The Middle Vychegda Mesolithic culture identified by him belongs to the Kama-Pechora type.
On the eve of the anniversary: how the Russian Federation celebrated the centenary of the 1917 revolution
Authors: Men'kovskiy V.
Published: May 2023

There are a lot of high-quality theoretical and concrete-historical studies in the modern Russian-language "revolutionary" historiography. The revolutionary events of 1917 constantly attracted the attention of historians and politicians. However, the official state position towards the revolution was sounded with caution and not entirely definitely in the Russian Federation. So, the “centenary” is a good occasion for analyzing the concepts and views proposed by the professional historical community in this social-political context. One of the most debated issues are common and opposite components of February and October, analysis of the relationship between the stages of the revolutionary process, periodization of the revolution. The paper considers the attitude to this complex of issues in the contemporary Russian-language historiography. The role and place of historical studies in the modern Russian reflection on the causes of revolution, its driving forces, progress and results are analyzed.
Hunting pits of Eastern Fennoscandia: archaeology and ethnography
Authors: Shahnovich M.
Published: May 2023

The purpose of the work is to analyze the method of hunting for large animals using trapping pits. These interesting archaeological artifacts are known in the tundra and North taiga zone of Northern Eurasia. The paper deals with the main problems of the initial stage of their study.

In the European part of Russia, the trapping pits were studied insignificantly. Extensive work was carried out in Sweden, Norway, and Finland. The pits were dug and provided with special long fences. The main huntable animals were reindeer and elk. In Russia, the trapping pits are known from the Karelian Isthmus to the Barents Sea. They were used from the Mesolithic to the XVI century. In the Middle Ages in Fennoscandia, the traps could be made by aborigines, Sami, and neighboring groups as Karelians, Finns, Germans. Against a comprehensive study of ethnography and archeology, the hunting pits are good informative archaeological assets.
At the origins of private insurance in the Vologda province: the authorized agent merchant I.T. Bovykin
Authors: Leyman I.
Published: May 2023

The paper describes the insurance activity of the Vologda merchant Ivan Tikhonovich Bovykin in the second third of the XIX century. The main source of materials was publications in the “Vologda Provincial Gazette” for 1838–1860. According to the data obtained, I.T. Bovykin was the most active authorized agent in the Vologda province, representing the largest and most famous private insurance institutions of the Russian Empire in different years. From 1847 to 1859, he, the only one in the province, was engaged in transport insurance. In the field of fire insurance despite high competition, I.T. Bavykin was active from 1848 to 1859, working on behalf of the country’s oldest insurance joint-stock company. Moreover, during the considered period he was the only agent in the province specializing in life insurance.
Vaccination Against SARS-CoV-2 and Mortality in Hemodialysis Patients: Three is Good
Authors: YAVUZ Demet , KARAGÖZ ÖZEN Düriye Sıla , BAŞBULUT Eşe , BİLGİN Melek , DEMİRAG Mehmet Derya
Published: May 2023

This study has investigated the vaccination rates against SARS-CoV-2 infection, antibody response to vaccine types, and factors affecting mortality in maintenance hemodialysis patients.98 of 143 patients undergoing hemodialysis in our clinic had 3 doses of BNT162b2 (Pfizer-BioNTechh) or CoronaVac (Sinovac Life Sciences) vaccine. Of these 98 patients, blood samples were obtained from 52 patients who agreed to obtain serum samples before and after vaccination. The serum samples were analyzed using the Abbott SARS-CoV-2 immunoassay designed to detect IgG antibodies against the receptor-binding domain of the S1 subunit of the spike protein of SARS-CoV-2. The rate of vaccination with at least one dose of vaccine was 85.3%, and the frequency of SARS-CoV-2 infection was 58.7%. The patients whose antibody titer was obtained after the third dose of vaccine (n=52) were divided into two groups according to the last vaccine type, as BioNTechh group of 16 patients and the Sinovac group of 36 patients. Considering all 52 patients with 3 doses of vaccine, the median antibody level was 397.3 (min-max) (4.5-40000) before the third vaccine dose, while 1325.3 (min-max) (10.5-40000) after the third vaccine dose (P
Relevance of Compliance on Islamic Law by The Construction of MUI DSN Fatwa on Murābahah Financing Products at BMT Khasanah Tawang, Weru
Authors: Retnowati May Shinta , Allhumahira Inaiyaya Zuhrifa
Published: May 2023

Murābahah is one of the financing products at BMT Khasanah Tawang, Weru Sragen that is most in demand by customers or the public. Basically there are no ribawi provisions from the profits of murabahah transactions. The concept of murabaha contract transactions is more transparent, because murabaha schemes in financial institutions are required to notify customers about price objects or products and agree on the benefits received by the institution. So transactions must be carried out in a trustworthy and honest manner. In Murabahah there are conditions that must be met by financial institutions in Indonesia. According to DSN MUI Fatwa No. 04/DSN-MUI/IV/2000, the first provision of article no 5 that banks buy goods needed by customers on behalf of their own banks, and these purchases must be lawful and free of usury, in other words the bank must first purchase goods or assets ordered by customers legally and free from usury. And in the DSN-MUI fatwa number 17/DSN-MUI/IX/2000, it has been explained in the first decree no. 2 that customers who are unable or unable to pay due to force majeure may not be subject to sanctions. Problems at BMT Khasanah Weru are customers who use capital financing for personal needs. The method used in this research is descriptive qualitative, data collection is done by means of interviews, documentation and observation. The results of the research on the application of Murābahahat BMT Khasanah Tawang, Weru the application of Murabahah financing products is in accordance with DSN MUI fatwa No. 04/DSN-MUI/IV/2000 and DSN-MUI fatwa number 17/DSN-MUI/IX/2000. BMT Khasanah Tawang addresses the problems of customers who use capital financing to buy personal needs with several evaluations.
Pengaruh Non-Performing Financing Pembiayaan Mudharabah dan Musyarakah Terhadap Profitabilitas dengan Dimoderasi oleh Good Corporate Governance Pada Bank Umum Syariah di Indonesia
Authors: Rusyda Deffa Salsabilah , Kholmi Masiyah , Mawardi Fahmi Dwi
Published: May 2023

The purpose of this study is to analyze and test the effect of Non-Performing Financing on Mudharabah Financing and Musyarakah Financing on Profitability moderated by Good Corporate Governance in Islamic Commercial Banks in Indonesia for the 2017-2021 period. This study uses a population of all Islamic Commercial Banks in Indonesia for the 2017-2021 period. The sampling method in this study used a purposive sampling method. The data acquisition technique in this study uses secondary data, namely in the form of an annual report for Islamic Commercial Banks in Indonesia in the 2017-2021 period. The data analysis method used is Multiple Linear Regression Analysis and Moderated Regression Analysis (MRA). The results of the study show that Non-Performing Financing of mudharabah financing and musyarakah financing simultaneously (Test F) has an effect on profitability and this study provides evidence that Non-Performing Financing of mudharabah financing and musyarakah financing has a negative and significant effect on Profitability in Islamic Commercial Banks. As well as Good Corporate Governance (GCG) can moderate Non-Performing Financing mudharabah financing and musyarakah financing on profitability.
Pengaruh ROA, CAR, LDR dan BOPO Terhadap Pertumbuhan Laba Pada Bank Umum di Indonesia yang Terdaftar di Otoritas Jasa Keuangan Tahun 2014-2018
Authors: Fitriyah Fitriyah , Wiryaningtyas Dwi Perwitasari , Prianto Fajar Wahyu
Published: May 2023

This study aims to (1) to determine the effect of ROA, CAR, LDR, and BOPO influence partially to profit growth (2) to know influence of ROA, CAR, LDR, and BOPO influence simultaneously to profit growth (3) to know among ROA , CAR, LDR, and BOPO most dominant effect on profit growth. The method used in this research is quantitative method. The results of research is multiple linear regression equation Y = -31,223 + 261,741 X1 + 9,704 X2 + 6,480 X3 + 24,699 X4 + e. Partially ROA have positive significant effect with value equal to 15,690, equal to 2,014, CAR have not significant effect with value equal to 1,768, equal to 2,014, LDR have significant positive effect with value equal to 3,871, equal to 2,014, BOPO have significant positive effect with value equal to 19,159, equal to 2,014. Simultaneously ROA, CAR, LDR, and BOPO influence to profit growth with value equal to 131,670, equal to 2.58. The most dominant variable in this research is BOPO with value 19,159.
Essentials: Teaching English to Young Learners in Primary School
Authors: Summer Theresa , Böttger Heiner
Published: May 2023

This contribution is about selected key issues related to the teaching of English to young learners (TEYL). Focusing particularly on primary school education, it reflects upon central theories and evidence-based research related to how young learners acquire and learn English. After an outline of central teaching principles, we develop the notion of a principled mindset. This provides the basis for a discussion of competence development and the integration of materials – focusing particularly on the role of authentic materials, scaffolding, classroom phrases, and the importance of literary texts. A basic introduction into how to plan competence-based lessons or lesson sequences follows. Throughout this contribution, examples aim to highlight the importance of a theoretical grounding for teaching practice.
Through the Anti-Bias Looking Glass : The Messages We Send Our Learners in (Primary) ELT
Authors: Loder-Buechel Laura
Published: May 2023

English language teaching materials in primary schools are fraught with images and examples that upon closer scrutiny, need unpacking or even replacement to steer learners away from stereotypes and to promote deeper thought and encourage exposure to the world. The purpose of this paper is to introduce readers to the Learning for Justice’s Social Justice Standards and show how these can be applied to standard coursebook images for basic A1, A2 and B1 level activities. These same activities can be applied to images and texts from other sources, such as international newspapers’ images of the day. Secondly, results of a classroom experiment with pre-service teachers using the Dispositions for Culturally Responsive Pedagogy Scale will be shared and ideas for prompting discussion provided. Finally, larger project ideas for EFL lessons in public primary schools to promote an anti-bias stance to education will be suggested.
Fixed and on-demand regimens of acetaminophen in periodontal surgery
Authors: Piardi Carla Cioato , Vaz Cristiane Galli , Ferreira Maria Beatriz Cardoso , Pilger Diogo , Fernandes Marilene Issa , Weidlich Patrícia
Published: May 2023

Aim: to evaluate the clinical efficacy of an acetaminophen analgesic by comparing its prescription in fixed versus ondemand schedules after periodontal surgery. The hypothesis of the study was that the fixed regimen would be more effective than the on-demand regimen for postoperative analgesics following periodontal surgery. Methods: An open randomized clinical trial was conducted. The 68 patients who needed total flap surgery to restore supracrestal tissue attachment or surgical treatment of periodontitis were randomized”. Visual Analogue Scale was used to assess pain. The fixed group (n = 34) received 500 mg of acetaminophen every 4 hours for 2 days. The on-demand group (n = 34) was instructed to use the acetaminophen “as needed,” at intervals of no less than 4 hours between doses. Ibuprofen was the rescue medication for both groups. Pain scores and medication use were recorded 2, 6, 12, 24 and 48 hours after the surgical procedure. The study was registered at the Brazilian Registry of Clinical Trials under RBR-7wv259. Results: The two groups did not differ in relation to the frequency or the intensity of pain in a 48-hour period (n=20 in the fixed group, and n=22 in the on-demand group), or even in the intention-to-treat (n=34 in each group). Individuals who experienced moderate to severe pain used rescue medication more frequently in both groups. No adverse events were reported. Conclusion: Both regimens were effective in controlling postoperative pain after periodontal surgery.
Saha (Yakut) İlinde Rus İşgali ve Misyonerliğin Rolü
Authors: KILIÇASLAN Yusuf , TOPSAKAL İlyas
Published: May 2023

Rus Çarlığı Sibirya hâkimiyeti için nehirler üzerinden hareketle Orta Lena’ya ulaşmış ve Saha boyları ile ilk temastan sonra bölgenin zenginliklerini fark etmiştir. XVII. Yüzyılın başlarından itibaren Rusların bölgeye ilgisi artmış ve keşif birlikleri ile ilerleme yoğunluk kazanmıştır. İlk başlarda kuzeyden güneye doğru olan işgal hareketinin yönü zamanla tüm Yakut bölgesini kapsayacak şekilde yeniden şekillendirilmiştir. Bölgeye intikal eden Kazak müfrezeleri bölgenin stratejik noktalarını işgal ederek ilk Rus müstahkemlerini inşa etmişilerdir. 1632’de Yakut kalesinin inşa edilmesi ile birlikte idari ve dini yapılanma eş zamanlı olarak gerçekleştirilmiştir. 1641’de Yakut Valiliği kurulmuş, ilk valiler Golovin ve Glebov ile birlikte resmi olarak ilk Ortodoks din adamları da (Filaret) bölgeye gönderilmiştir. Böylece Ortodoks misyonerlik faaliyetlerinin ilk temsilcileri bölgeye gelmiştir. İlk dini yapılar ise askerler tarafından inşa edilen kalelerin içerisine bina edilmiştir. İlk dini yapıların ortaya çıkması ile birlikte artık bölgede misyonerlik faaliyetleri için ortam oluşmaya başlamıştır. Özellikle Saha boyları arasında veya yakınlarında kurulan kiliseler ve manastırlar bölgenin Ruslaştırılmasına ve Hıristiyanlaştırılmasına katkı sağlayan en önemli faktörlerdir. Ruslar tarafından işgal edilen bölgede misyonerler ve din adamları dışında entelektüel birikime sahip insanların varlığından bahsetmek oldukça güçtür. Bu nedenden ötürü Rus devletini temsilen işgali Kazak müfrezeleri gerçekleştirmişlerse de bölgede kalıcı olmak adına ortak payda oluşturanlar misyonerler ve din adamlarıdır.
The word soup handicap: Why finding the right way to address people like me is tough
Authors: GR Raamesh
Published: May 2023

I have been blind in the left eye after a childhood accident, and fall into the category of ‘Divyāngjan’ (people with divine body parts), but that is not a term I like being described by. I prefer to be known by a handicap that restricts my activity, without any attempt to patronise with pity rather than empathy. This also goes for the several politically correct terms being used to describe people with disabilities these days. Most of these reflect a patronising attitude and serve no purpose. If people sincerely mean well, they need to engage practically with the obstacles faced by those dealing with disabilities. Merely changing descriptive terms, and without consulting those most affected, is like putting a band aid on the disability.
DETERMINING SUPPLY CHAIN STRATEGIES BY SWOT ANALYSIS: A CASE STUDY
Authors: AKSOY Songül
Published: May 2023

A strategy is a plan of action designed to achieve a long-term or general purpose. It is a military term, and its origin goes back to Sun Tzu. Its use in the modern sense coincides with the 1980s. In the increasingly competitive environment in recent years, businesses need to make a difference in the market, increase their profitability, closely follow technological developments, etc. They attach importance to developing their strategies in the corporate sense and in the field of business management strategies. However, it has been determined that enterprises cannot develop in the field of supply chain management strategies, which is one of their functional strategies, especially in the researches. Determining supply chain strategies will enable them to compete in the market, especially in terms of reducing costs, increasing customer experience, adopting innovative approaches or quality. Businesses may choose to compete in only one of these factors, or they may adopt several factors. In this study, a supply chain strategy determination study was carried out in a company that has a very important position in the wood-based panel industry sector and has adopted supply chain management, but where no strategic decisions or projects have been created. SWOT analysis was used in terms of company and supply chain process. Ten (10) supply chain strategies were determined.
OVERTOURISM AND DESTINATION BRANDING: THE MEDIATING ROLE OF FUNCTIONAL AND EMOTIONAL VALUES AMONG TOURISTS
Authors: Zarhari Nurul Ain Atiqah , Mat Som Ahmad Puad , Azinuddin Muaz , Hanafiah Mohd Hafiz
Published: May 2023

Purpose – This research note offers an integrative model of destination branding in the context of overtourism in an ecotourism destination. This study examines the impact of overtourism on the functional and emotional values and destination branding. Design – A quantitative research design was used. The research findings were collected through purposive sampling and a cross-sectional approach. Methodology/Approach – Three hundred and thirty-three (333) valid responses were utilised for hypothesis testing. Measurement of the study model and their interrelationship were examined based on Partial-least square-Structural Equation Modelling (PLS-SEM). Findings – The empirical results revealed that overtourism impacts tourists’ functional and emotional value and positively influences destination branding. In contrast, overtourism impacts both tourists’ functional and emotional values adversely. As predicted, tourists’ functional and emotional values mediate the relationship between the effects of overtourism and the destination branding. Originality of the research – This study makes a unique theoretical contribution to the destination branding literature by integrating and empirically testing the interrelationships between overtourism impacts, functional values, emotional values, and destination branding from the tourists’ perceptions. The results of the study are also valuable for destination managers and policy makers to develop sustainable destination branding for their respective tourism destinations.
Mesotelioma Peritoneal Maligno - Um relato de caso
Authors: Taveira Eliseu José Fleury , Santana Lanúscia Morais de , Rosa Victor Domingos Lisita , Gabriel Augusto Ribeiro , Vega Maria Cecilia Monteiro Dela , Azevedo Fernando Santos de , Gomes Arthur Moreira
Published: May 2023

Resumo

Introdução: o Mesotelioma Peritoneal Maligno (MPM) é uma doença rara e letal com variável grau de agressividade. A morbimortalidade está relacionada com a carga de doença tumoral e a sobrevida mediana sem tratamento é de cerca de 12 meses. Quimioterapia baseada em cisplatina é o tratamento padrão nos casos de doença avançada irressecável, ou nos pacientes que declinam cirurgia, associado a quimioterapia hipertérmica intraperitoneal (HIPEC). Desenvolvimento: paciente, 54 anos, com histórico de perda ponderal, desconforto e aumento progressivo de volume abdominal, com imagem evidenciando espessamento peritoneal difuso e ascite, foi submetido a laparoscopia e biópsia com achados positivos para MPM, sendo realizada quimioterapia de 3ª linha com cisplatina e gemcitabine, seguido de manutenção com gemcitabine, apresentando resposta completa, sendo, portanto, caso de resposta excepcional e atípica para doença. Considerações finais: Apesar dos fatores de prognóstico desfavoráveis e rápida progressão aos esquemas iniciais, o paciente do caso apresentou melhora clínica importante e ausência de doença mensurável com esquema de cisplatina e gemcitabine, seguido de gemcitabine de manutenção. Comparado com dados vigentes na literatura, tal resposta é excepcional e atípica, haja vista as características biológicas tumorais da doença.

Palavras-chave: Neoplasias Peritoneais; Oncologia; Antineoplásicos Alquilantes; Antimitóticos

Abstract

Objective: Malignant peritoneal mesothelioma (MPM) is a rare and lethal disease with variable degree of aggressiveness. Morbidity and mortality are related to the burden of tumor disease and median survival without treatment is about 12 months. Cisplatin-based chemotherapy is the standard of treatment in cases of advanced unresectable disease or in patients who decline surgery associated with intraperitoneal hyperthermic chemotherapy (HIPEC). Development: a 54-year-old patient with a history of discomfort, progressive increase in abdominal volume and weight loss, with an image showing diffuse peritoneal thickening and ascites, underwent laparoscopy and biopsy with positive findings for MPM, undergoing 3rd-line chemotherapy with cisplatin and gemcitabine, followed by maintenance with gemcitabine, showing a complete response, therefore being an exceptional and atypical response to disease. Final considerations: Despite the unfavorable prognostic factors and rapid progression to the initial regimens, the patient showed significant clinical improvement and absence of measurable disease with cisplatin and gemcitabine regimen, followed by maintenance gemcitabine. Compared with data from the literature, exceptional and atypical presentation, due to the tumor's biological characteristics of the disease.

Keywords: Peritoneal Neoplasms; Medical Oncology; Antineoplastic Agents, Alkylating; Antimitotic Agents
RELATO DE CASO: RECIDIVA LEISHMANIOSE VISCERAL GANGLIONAR EM UM PACIENTE COINFECTADO PELO VÍRUS DA IMUNODEFICIÊNCIA HUMANA
Authors: Benicio Bossler Caroline , Farias Porto Letícia Fernanda , Veloso Costa Coutinho Olivia Maria
Published: May 2023

Introdução: Leishmaniose Visceral (LV) é uma zooantroponose endêmica no país. O Vírus da Imunodeficiência Humana (HIV), causa imunodepressão que predispõe à coinfecção LV-HIV. O objetivo deste estudo é relatar um caso de recidiva de LV acometendo apenas cadeia de gânglios linfáticos difusamente, acompanhado pelo Serviço de Infectologia do Hospital Geral de Palmas. Desenvolvimento: Paciente JHA 34 anos, natural de Bacabal-MA, com diagnóstico anterior em 2013 de HIV e história de LV tratada resolutivamente há 5 meses com Anfotericina B Lipossomal e manutenção com profilaxia secundária. O paciente iniciou acompanhamento há 3 anos junto a Infectologia sendo diagnosticado com LV de caráter ganglionar difuso por meio de biópsia mesentérica. Retornou em fevereiro de 2022 com quadro de adenomegalia difusa (submandibular, cervical, axilar, inguinal), febre moderada, inapetência e perda ponderal a esclarecer. Laboratorialmente paciente apresentava pancitopenia. A tomografia de pelve confirmou o aumento dos gânglios. Com tal evidência, o mesmo foi requerido a internação hospitalar. Durante esse tempo o paciente fez uso de Anfotericina B Lipossomal durante 10 dias e recebeu alta da enfermaria, assintomático com regressão linfonodal e retorno em 15 dias ambulatorialmente para manutenção com profilaxia secundária até CD4 > 350. Considerações Finais: Tal caso, nos confirma que o agente da doença pode permanecer em órgãos do sistema monocítico fagocitário, sendo capaz de permanecer por longo período no indivíduo infectado. Pode ocorrer, devido a diversos fatores que afetam a resistência do hospedeiro, a reativação da doença. Neste caso, o paciente recebeu alta da profilaxia com CD4 > 200 e mesmo assim houve recidiva. Isso ilustra um caso atípico de LV, sem hepatoesplenomegalia e gamaglobulinemia. E reitera a importância do seguimento da profilaxia secundária em pacientes HIV por maior período.

 

Palavras-chave: Leishmaniose Visceral; Recidiva; Doenças Linfáticas.
Experimental Analysis of the Effectiveness of Sodium Hexametaphosphate as Calcium Carbonate Scales Inhibitor
Authors: Paz Paulo , Netto Theodoro Antoun
Published: May 2023

Offshore oil and gas production is known to present severe flow assurance issues, in particular calcium carbonate (CaCO3) scale deposition, as its formation reaction is influenced by temperature and pH changes that occur during production. This study investigated the calcium carbonate scaling process using a newly developed 1-inch diameter mesoscale loop and also the efficiency of sodium hexametaphosphate (SHMP) as a scale inhibitor for calcium carbonate under drastic conditions of temperature, flow rate, and scaling ions concentration. The relationship between flow rate, temperature, experimental time, and CaCO3 formation parameters was evaluated using a dynamic methodology designed for the mesoscale loop. Moreover, scanning electron microscopy (SEM) images and energy-dispersive spectrum (EDS) chemical analysis were used to study changes in the microstructure and the elemental composition of the deposits in the absence and presence of the scale inhibitor. The inhibition effect was found satisfactory, as CaCO3 deposition greatly decreased. The deformed structures of the CaCO3 crystals observed by SEM images and EDS analysis helped visualize the changes due to the SHMP. Finally, the temperature changes due to the accumulation of deposits through thermal images were helpful in explaining what was happening inside the pipes system during the scaling tests.
Hyperreflective Material in Patients with Non-neovascular Pachychoroid Disease
Authors: Maruyama-Inoue Maiko , Yanagi Yasuo , Mohamed Shaheeda , Inoue Tatsuya , Kitajima Yoko , Ikeda Shoko , Kadonosono Kazuaki
Published: May 2023

Background: This study aimed to report eleven cases of non-neovascular pachychoroid disease with hyperreflective material (HRM) that occurred in Japanese patients.
Methods: A retrospective review of data from eleven patients who had non-neovascular retinal pigment epithelium (RPE) protrusion with HRM in the neurosensory retina between March 2017 and June 2022 was conducted. Clinical examination, color fundus photography, fluorescein angiography, spectral-domain optical coherence tomography (SD-OCT), and OCT angiography data were analyzed. Main outcome measureswere patient characteristics, changes in SD-OCT findings, and symptom outcomes.
Results:All cases had RPE protrusion and HRM with dilated choroidal veins, which were characteristic of pachychoroid disease. However, none of the cases had macular neovascularization (MNV). In 9 eyes (81.8%), HRM improved spontaneously without intervention and resulted in alterations in RPE, referred to as pachychoroid pigment epitheliopathy (PPE) or focal choroidal excavation (FCE). In these cases, symptoms such as metamorphopsia and distortion improved without treatment. In the remaining two cases (18.2%), HRM still persisted during the follow-up period.
Conclusion: There are some cases of non-neovascular pachychoroid disorder with HRM, which might be a new entity of pachychoroid spectrum disease or an early stage of PPE or FCE. These cases should not be misdiagnosed as MNV, and careful observation is necessary.
GUP modified Wigner function using classical-quantum unified framework
Authors: Sen Abhijit , Parida Bikram Keshari
Published: May 2023

The generalized uncertainty principle (GUP) is a natural consequence of many proposed
quantum gravity theories which further indicates the modification of the quantum mechanics and
classical mechanics. A unified classical-quantum framework also leads to the interpretation of a
Winger phase-space distribution of a state as a KvN wave function. In this article, we utilize the
classical-quantum unified framework to calculate the expression for the GUP modified Wigner
function of a classical harmonic oscillator in the configuration space instead of the conventional
approach of utilising the momentum space. Further, we plot the modified Wigner functions and
show that they are similar to what has been obtained before in the past literature.
Deformation Evaluation and Displacement Forecasting of Baishuihe Landslide after Stabilization based on Continuous Wavelet Transform and Deep Learning
Authors: Liu Yuting , Teza Giordano , Nava Lorenzo , Chang Zhilu , Shang Min , Xiong Debing , Cola Simonetta
Published: May 2023

Baishuihe Landslide is a large active landslide that threatens shipping transportation in the Three Gorges Reservoir (China). A manual monitoring system has been active since 2003. However, after the realization of some intervention works in 2018-2019, new automatic instruments providing continuous data on displacements, rainfall, reservoir water level, and groundwater table were installed. The data recorded by the new system show that these works led to an effective stabilization improvement since the present displacement rate is lower than that detected before interventions. However, the relevance of the Three Gorges basin and the potential hazard of a possible collapse requires a reliable forecast of the landslide evolution in a time scale from a few hours to a few days. To this aim, a two steps procedure is here proposed. In the first step, after a preliminary preprocessing-denoising of data, carried out by means of Discrete Wavelet Transform (DWT), a Continuous Wavelet Transform (CWT) procedure is used to provide scalograms of the time series of three quantities, e.g., landslide displacement rate, rainfall and the difference of water level between the piezometer and reservoir water level. In the second step, to evaluate the relationships among the velocity trend and the other significant quantities and obtain a reliable velocity forecast, the images given by binding together two or three scalograms of the mentioned quantities were analyzed with a Convolutional Neural Network (CNN) tool. Several trials with different combinations of input time series of 2 or 3 quantities were carried out in order to recognize the factors which mainly affect the current displacement evolution. The results show that, after the works, rainfall is an important factor inducing deformation acceleration. The hydrodynamic pressure induced by the difference between the ground water pressure and reservoir water level also plays a dominant role in accelerating the Baishuihe landslide. Furthermore, the coupling of rainfall and hydrodynamic pressure produces displacement velocities higher than what the quantities singularly do. These results provide valuable indications for optimizing the monitoring configuration on the landslide and obtaining velocity forecasts in a few hours/days.
The effect of family communication on anxiety and depression among adolescents: the mediating role of intimate relationship violence and problematic internet use
Authors: Huang Xin-cheng , Zhang Yue-ning , Wu Xiao-yu , Jiang Yang , Deng Yu-qian , Luo Yuan , Zhao Li-ping , Liu Qin-ling , Luo Sheng-yue , Wang Yan-yan , Jiang Mao-min , Wu Yi-bo
Published: May 2023

[Objective]: The objective of this study is to explore the relationship between family communication, intimate relationship violence, problematic internet use, anxiety, and depression and validate their potential mediating role.
[Methods]: The study population consisted of Chinese adolescents aged 12 to 18 years, and a cross-sectional survey was conducted in 2022. Structural equation models were constructed using AMOS 25.0 software to examine the factors that influence adolescent anxiety and depression and the mediating effects of problematic internet use and intimate relationship violence.
[Results]: The results indicate that family communication was significantly and negatively related to intimate relationship violence (β = -0.309, p < 0.001), problematic internet use (β = -0.039, p < 0.05), depression (β= -0.081, p < 0.001), and anxiety (β = -0.092, p < 0.001). And the finds also indicate that imitate relationship violence mediated the relationships between family communication and depression (β = -0.108, CI: -0.133 -0.087), and between family communication and anxiety (β= -0.098; CI: -0.124 -0.079). Chain indirect effects between family communication and depression (β = -0.051; CI: -0.065 -0.041) or anxiety (β = -0.046; CI: -0.057 -0.037) via imitate relationship violence and then through problematic internet use were also found in the present study.
[Conclusions]: In conclusion, positive family communication is crucial in reducing anxiety and depression in adolescents. Moreover, problematic internet use and intimate relationship violence mediate the effects of positive family communication on anxiety and depression. Therefore, improving family communication and promoting interventions aimed at reducing intimate relationship violence and problematic internet use can help reduce anxiety and depression in adolescents, thus promoting their healthy development.
Self-assembling peptide and nano-silver fluoride in remineralizing early enamel carious lesions: Randomized Controlled Clinical Trial
Authors: Atteya Sara M. , Amer Hala A. , Saleh Susan M. , Safwat Yara
Published: May 2023

Background
Nanoparticles and regenerative biomineralization are new caries prevention technologies. This study assessed the remineralizing effect of self-assembling peptide (P11-4), Nanosilver Fluoride (NSF) and sodium fluoride (NaF) on white spot lesions (WSLs) in permanent teeth.
Methods
Sixty six young adults with WSLs on buccal surfaces in permanent teeth and ICDAS code 1 or 2, were randomly assigned to one of three groups; P11-4, NSF or NaF. Assessment of ICDAS scores, lesion activity and diagnodent readings of lesions were done at baseline and after 1, 3, 6 and 12 months of agents’ application. Comparisons between groups were made using X2 test and comparison within groups were made using McNemar test. Multilevel logistic regression analysis was used to assess the effect of agents on change of ICDAS scores after 12 months.
Results
There were 147 teeth in 66 patients; mean ± SD age = 13.46 ± 4.31 years. There was significant difference in change of ICDAS scores among the three groups after 3 and 6 months (p = 0.005). The regression in ICDAS score increased in all groups in all follow-up intervals with the greatest was among P11-4 group (54.5% after 12 months). Lesion activity assessment has shown significant difference between the three groups with the greatest reduction of lesion activity among the P11-4. Multilevel regression showed non-significant reduction of ICDAS in P11-4 and NSF varnishes compared to NaF varnish (AOR = 2.256, 95% CI: 0.58–8.77 and AOR = 2.119, 95% CI: 0.588,-7.636 respectively).
Conclusion
P11-4 and NSF varnish reduced the ICDAS scores, caries activity and diagnodent readings of WSLs in permanent teeth. However, the change in ICDAS scores was not significantly different from NaF.
Trial Registration
This trial was prospectively registered on the clinicaltrials.gov registry with ID: NCT04929509 on 18/6/2021
Decellularized liver hydrogel enhances cell engraftment in orthotopic hepatocyte transplantation by promoting cell–cell interaction and angiogenesis
Authors: Udagawa Daisuke , Nagata Shogo , Yagi Hiroshi , Nishi Kotaro , Morisaku Toshinori , Adachi Shungo , Nakano Yutaka , Tanaka Masayki , Hori Shutaro , Hasegawa Yasushi , Abe Yuta , Kitago Minoru , Kitagawa Yuko
Published: May 2023

Hepatocyte transplantation (HCT) is a potential bridging therapy or an alternative to liver transplantation. Conventionally, single-cell hepatocytes are injected via the portal vein. This strategy, however, has yet to overcome poor cell engraftment and function. Therefore, we developed an orthotopic hepatocyte transplantation method using a liver-derived extracellular matrix (L-ECM) gel. PXB cells (flesh mature human hepatocytes) were dispersed into the hydrogel solution in vitro, and the gel solution was immediately gelated in 37 ℃ incubators to investigate the affinity between mature human hepatocyte and the L-ECM-gel. During the 3-day cultivation in hepatocyte medium, PXB cells formed cell aggregates via cell–cell interactions. Quantitative analysis revealed human albumin production in culture supernatants. For the in vivo assay, PXB cells were encapsulated in the L-ECM gel and transplanted between the liver lobes of normal rats. Pathologically, the L-ECM gel was localized at the transplant site and retained PXB cells. Cell survival and hepatic function marker expression were verified in another rat model wherein thioacetamide was administered to induce liver fibrosis. Moreover, cell–cell interactions and angiogenesis were enhanced in the L-ECM gel compared to that in the collagen gel. Our results indicate that L-ECM gels can help engraft transplanted hepatocytes and express hepatic function as a scaffold for cell transplantation.