bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação da Saúde Bucal e Análise Microbiológica de Pacientes em Unidade de Terapia Intensiva
Authors: Bohneberger Gabriela , Couto Thaynara , Dallanora Fábio José , Dallanora Lea Maria Franceschi , Martini Geórgia Ribeiro , De Dea Bruna Eliza , Dirschnabel Acir José , Ramos Grasieli de Oliveira , Dallacosta Fabiana Meneguetti
Published: August 2023

Introdução: Pacientes internados em unidade de terapia intensiva (UTI) estão mais suscetíveis ao desenvolvimento de infecções hospitalares, as quais podem ser originadas a partir de focos infecciosos presentes na cavidade oral ou pela ausência de higienização adequada. Objetivo: Avaliar a condição oral e relacionar com as alterações da microbiota durante a permanência dos pacientes internados na unidade de terapia intensiva de um hospital universitário. Métodos: Trata-se de um estudo quantitativo experimental. Foram avaliados 64 pacientes quanto a condição de higiene oral, dados clínicos e coletas microbiológicas realizadas em três momentos distintos: C1, C2 e C3, correspondentes à 24, 72 e 168 horas após à internação. O material coletado foi submetido a sete testes microbiológicos para identificação dos microrganismos presentes. Resultados: O exame clínico apresentou índice de higiene oral simplificado alto em todos os momentos, 25% com cárie ativa, 17% com raízes residuais e 11% com outros focos de infecção. Mais de 50% apresentaram algum grau de ressecamento da mucosa em C1 e nas coletas posteriores se manteve ou aumentou. Quanto ao exame microbiológico foram identificadas 25 colônias distintas de microrganismos, dentre elas Candida sp., Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis e Enterobacter, microrganismos com potencial patogênico quando encontrados na cavidade oral. Conclusão: Os fatores clínicos do paciente como o alto índice de higiene oral, presença de focos infecciosos e ressecamento das mucosas associados aos microorganismos com potencial patogênico encontrados na cavidade bucal evidenciam a importância da higiene bucal nas unidades de terapia intensiva, para que com a diminuição do biofilme bucal seja reduzida a quantidade e a patogenicidade destes microrganismos. Reduzindo a ocorrência de infecções nosocomiais, principalmente a pneumonia associada à ventilação mecânica, que consequentemente podem gerar maior permanência do paciente em ambiente hospitalar.
A digital water strategy based on the digital water service concept to support asset management in a real system
Authors: Laucelli Daniele Biagio , Enriquez Laura Vanessa , Ariza Andres David , Ciliberti Francesco Gino , Berardi Luigi , Giustolisi Orazio
Published: August 2023

Digital transformation currently represents a clear opportunity for innovation in better management and planning of water distribution networks. Coupled with the increased investments in assets and the growing need of safe and high-quality water for the public, new opportunities are opening for digital tools that can help operators, consultant companies and researchers to support asset management tasks. This work presents the applications of a comprehensive digital water strategy on two real case studies with information provided by the Italian water company Acquedotto Pugliese. The proposed digital water strategy is based on the paradigm named digital water services. The strategy starts by improving the value of GIS and existing models' data. Then, advanced hydraulic modelling and topological analyses, using the complex network theory, along with artificial intelligence methodologies are the basis for the development of digital water services, which are the engineering apps that use the network digital twin to support the different stages of asset management, i.e., digital water strategy.
Community intervention trial for estimating risk of acute gastrointestinal illness from groundwater-supplied non-disinfected drinking water
Authors: Borchardt Mark A. , Kieke Burney A. , Spencer Susan K. , Lambertini Elisabetta , Burch Tucker R. , Loge Frank J.
Published: August 2023

By community intervention in 14 non-disinfecting municipal water systems, we quantified sporadic acute gastrointestinal illness (AGI) attributable to groundwater. Ultraviolet (UV) disinfection was installed on all supply wells of intervention communities. In control communities, residents continued to drink non-disinfected groundwater. Intervention and control communities switched treatments by moving UV disinfection units at the study midpoint (crossover design). Study participants (n = 1,659) completed weekly health diaries during four 12-week surveillance periods. Water supply wells were analyzed monthly for enteric pathogenic viruses. Using the crossover design, groundwater-borne AGI was not observed. However, virus types and quantity in supply wells changed through the study, suggesting that exposure was not constant. Alternatively, we compared AGI incidence between intervention and control communities within the same surveillance period. During Period 1, norovirus contaminated wells and AGI attributable risk from well water was 19% (95% CI, −4%, 36%) for children <5 years and 15% (95% CI, −9%, 33%) for adults. During Period 3, echovirus 11 contaminated wells and UV disinfection slightly reduced AGI in adults. Estimates of AGI attributable risks from drinking non-disinfected groundwater were highly variable, but appeared greatest during times when supply wells were contaminated with specific AGI-etiologic viruses.
Application of Feature Definition and Quantification in Biological
Sequence Analysis
Authors: Chen Weiyang , Li Weiwei
Published: August 2023

Biological sequence analysis is the most fundamental work in bioinformatics. Many research
methods have been developed in the development of biological sequence analysis. These methods
include sequence alignment-based methods and alignment-free methods. In addition, there are also
some sequence analysis methods based on the feature definition and quantification of the sequence itself.
This editorial introduces the methods of biological sequence analysis and explores the significance
of defining features and quantitative research of biological sequences.
CAD System Design for Two-class Brain Tumor Classification using
Transfer Learning
Authors: Bhardawaj Falguni , Jain Shruti
Published: August 2023

Background:

The occurrence of brain tumors is rapidly increasing, mostly in the younger
generation. Tumors can directly destroy all healthy brain cells and spread rapidly to other parts.
However, tumor detection and removal still pose a challenge in the field of biomedicine. Early detection
and treatment of brain tumors are vital as otherwise can prove to be fatal.

Objective:

This paper presents the Computer Aided Diagnostic (CAD) system design for two classification
of brain tumors employing the transfer learning technique. The model is validated using machine
learning techniques and other datasets.

Methods:

Different pre-processing and segmentation techniques were applied to the online dataset. A
two-class classification CAD system was designed using pre-trained models namely VGG16,
VGG19, Resnet 50, and Inception V3. Later GLDS, GLCM, and hybrid features were extracted
which were classified using Support Vector Machine (SVM), k-Nearest Neighbor (kNN), and Probabilistic
Neural Network (PNN) techniques

Results:

The overall classification accuracy using Inception V3 is observed as 83%. 85% accuracy
was obtained using hybrid GLCM and GLDS features using the SVM algorithm. The model has been
validated on the BraTs dataset which results in 84.5% and 82% accuracy using GLCM + GLDS +
SVM and Inception V3 technique respectively.

Conclusion:

2.9% accuracy improvement was attained while considering GLCM + GLDS + SVM
over kNN and PNN. 0.5% and 1.2% accuracy improvement were attained for CAD system design
based on GLCM + GLDS + SVM and Inception v3 model respectively.
Traditional Medicinal Plants in Cancer Therapy and Chemoprevention:
A Review of Preclinical and Clinical Studies
Authors: Sidhic Jameema , George Satheesh , Narayanankutty Arunaksharan
Published: August 2023

Cancer has become a significant public health concern in the past few decades, and it is
now the world's second cause of death. Although there are various types of cancer treatments, such
as chemotherapy, immune therapy, radiation, hormone therapy, gene editing, etc., they all have
adverse reactions and significant failings. Plant and dietary mixtures have been utilized to treat
malignant growth over the entire course of time. These mixtures likewise might be helpful in anticipation
of malignant growth. Chemoprevention is cancer prevention that makes use of plant phytochemicals
and synthetic substances. Because of their reduced toxicity and inexpensive cost, phytoconstituents
are gaining much interest in chemoprevention effectiveness. As a result, the chemopreventive
power of naturally occurring phytochemicals is of great interest. Populace studies propose
that a decreased gamble of malignant growth is related to the maximum usage of vegetables and
natural products. This review summarised the latest research on plants and their chemicals targeting
various malignancies and their mechanisms of cancer suppression by modulating multiple signaling
pathways. It provides a small outline of green synthesized nanoparticles, an emerging area to combat
cancer.
The Effect of Preconception Counseling According to the Theory of
Planned Behavior with the Presence of the Spouse on Preconception
Health Behaviors – A Training Trial Study
Authors: Abiri Leila , Vakilian Katayon , Shabani Fatemeh , Zamanian Maryam , Sooki Zahra
Published: August 2023

Background and Objective:

Preconception care consists of biomedical, behavioral, and social services, along with health interventions, for women and couples before conception to improve
their health status and reduce individual and environmental high-risk behaviors. This study aimed to
assess to preconception counseling according to the theory of planned behavior with the presence of
the spouse on preconception care behaviors.

Materials and Methods:

This study was an educational trial. The researcher randomly divided women
into two intervention and control groups. The control group only received routine preconception care
in the presence of the spouse. The intervention group, according to the theory of planned behavior, received 60-minute face-to-face counseling weekly sessions. The main outcomes of behavior were divided into two categories: screening tests and vaccinations and individual lifestyle (exercise, nutrition,
and smoking). The questions also focused on men’s check-up tests. The data normality was analyzed
by group, variable type, and measurement stage using the Shapiro-Wilk test and the skewness and kurtosis results. Levene's and Mochli's tests were used to check the homogeneity of variances and assumption of sphericity, respectively. Data were analyzed using independent t-tests, chi-square, repeated measures test, and SPSS 26 software.

Result:

The previous lifestyle behaviors were respectively 15.22 + 2.836, 15.49 + 2.769, and 16.84 +
1.894 before, immediately, and 4 weeks after the intervention in control, and 12.70 + 3.69, 15.53 +
3.02, and 16.60 + 2.73 in the intervention group, indicating no significant differences (p=0.08). However, the two groups significantly increased healthy lifestyles over time(p=0.001). The results also
showed that the mean of test and vaccination was respectively 4.44 ± 2.99, 2.75 ± 6.42, and 2.49 ±
8.31 before, immediately, and 4 weeks after the intervention in control, and 4.09 + 3, 6.74 + 2.87, and
8.35 + 2.37 in the intervention group, indicating no significant differences(p=0.99).

Conclusion:

Since the presence of the husband during the training of women's pre-pregnancy care can
affect their health behaviors regardless of the type of intervention, men are suggested to attend prepregnancy training and consultations for at least one session.
Improving Hydroxytyrosol Derivatives Content in Virgin Olive Oil using
Ultrasound-assisted Maceration with Olive Leaf Extract
Authors: Christou Atalanti , Alkiviadi Aristi , Goulas Vlasios
Published: August 2023

Background:

Olive oil is rich in monounsaturated fatty acids and is an essential Mediterranean diet component. Many of its health benefits are associated with the presence of phenolic
compounds. Several strategies for the enhancement of the phenolic content and, more specifically,
the concentration of hydroxytyrosol derivatives in olive oils have been proposed, as extra virgin
olive oil (EVOO) of high phenolic content is preferred by health-conscious consumers.

Methods:

The supplementation of EVOO with hydroxytyrosol derivatives from olive leaf extract
was performed with the employment of ultrasound-assisted maceration at different concentration
levels (2 g·L-1 oil and 4 g·L-1 oil), temperatures (20 and 40°C), and maceration times (20 and 40
min). The phenolic contents of enriched EVOOs were determined by spectrophotometric and
HPLC methods. In addition, the effect of supplementation on the physicochemical parameters of
EVOOs, namely acidity and extinction coefficients (K232 and K270), was also studied.

Results:

The addition of extract slightly increased the acidity values and extinction coefficients of
the samples, and at the same time, it significantly improved their phenolic composition. The use of
appropriate ultrasound-assisted maceration parameters (addition of olive leaf extract at a concentration level of 2 g L-1 at 20°C for 20 min) provided EVOO with acceptable values for total acidity
(<0.8%), K232 (<2.5), and K270 (<0.22), high contents of total phenolics and flavonoids, and improved hydroxytyrosol derivative contents.

Conclusion:

The enrichment of EVOO with leaf extract is a promising strategy to enhance its content in hydroxytyrosol derivatives, providing premium EVOOs with respect to their bioactive composition.
Depression Symptoms Amongst Older Brazilian and Chinese Women
Submitted to Different Social Distancing Measures Rigidness During
COVID-19 Outbreak
Authors: Bohn Lucimere , Lucena Clarice Martins , dos Santos André Pereira , Chen Sitong , Abdalla Pedro Pugliesi
Published: August 2023

Background:

It is plausible that depression symptoms and disrupting sleep quality were
differently affected according to the rigidity of social distancing during the COVID-19 outbreak.

Objective:

To describe and compare depression symptoms and sleep quality amongst older Brazilian
and Chinese women who were submitted to different social distancing measures (less rigid
(Brazil) versus more rigid (China)).

Methods:

This observational cross-sectional study assessed urban older women who underwent
home confinement with less (Brazil; n=1015) or more (China; n=644) rigidity. Socio-demographic
correlates, general health information, depression symptoms [Geriatric Depression Scale (GDS-
15)], and sleep quality [Pittsburgh Sleep Quality Index (PSQI)] were assessed through interviews.

Results:

1659 older women (66.74 ± 5.48 years old; 38.8% Chinese; 61.2% Brazilian) were included
for analysis. 22% of Brazilians and 19.6% of Chinese women presented depression symptoms.
The frequency of bad sleepers was 56.4% and 37.7% amongst Brazilian and Chinese older
women, respectively. After adjusting for socio-demographic variables, general health status, and
PSQI global score, Chinese women had a significantly higher score of depression symptoms (3.88
± 0.13) compared to the Brazilians (3.26 ± 0.10; p < 0.001).

Conclusion:

The frequency of poor sleep quality was very high regardless of the country. After adjusting
for confounders and sleep quality, older Chinese women had a significantly superior score
of depression symptoms exacerbating psychological distress by confinement rigidness.
Association Between Online Health Information–Seeking Behaviors by Caregivers and Delays in Pediatric Cancer: Mixed Methods Study in China
Authors: Wang Jiamin , Zhen Xuemei , Coyte Peter C , Shao Di , Zhao Ni , Chang Lele , Feng Yujia , Sun Xiaojie
Published: August 2023

Background

Pediatric cancer patients in China often present at an advanced stage of disease resulting in lower survival and poorer health outcomes. One factor hypothesized to contribute to delays in pediatric cancer has been the online health information–seeking (OHIS) behaviors by caregivers.

Objective

This study aims to examine the association between OHIS behaviors by caregivers and delays for Chinese pediatric cancer patients using a mixed methods approach.

Methods

This study used a mixed methods approach, specifically a sequential explanatory design. OHIS behavior by the caregiver was defined as the way caregivers access information relevant to their children’s health via the Internet. Delays in pediatric cancer were defined as any one of the following 3 types of delay: patient delay, diagnosis delay, or treatment delay. The quantitative analysis methods included descriptive analyses, Student t tests, Pearson chi-square test, and binary logistic regression analysis, all performed using Stata. The qualitative analysis methods included conceptual content analysis and the Colaizzi method.

Results

A total of 303 pediatric cancer patient-caregiver dyads was included in the quantitative survey, and 29 caregivers completed the qualitative interview. Quantitative analysis results revealed that nearly one-half (151/303, 49.8%) of patients experienced delays in pediatric cancer, and the primary type of delay was diagnosis delay (113/303, 37.3%), followed by patient delay (50/303, 16.5%) and treatment delay (24/303, 7.9%). In this study, 232 of the 303 (76.6%) caregiver participants demonstrated OHIS behaviors. When those engaged in OHIS behaviors were compared with their counterparts, the likelihood of patient delay more than doubled (odds ratio=2.21; 95% CI 1.03-4.75). Qualitative analysis results showed that caregivers’ OHIS behaviors impacted the cancer care pathway by influencing caregivers’ symptom appraisal before the first medical contact and caregivers’ acceptance of health care providers’ diagnostic and treatment decisions.

Conclusions

Our ﬁndings suggest that OHIS among Chinese pediatric caregivers may be a risk factor for increasing the likelihood of patient delay. Our government and society should make a concerted effort to regulate online health information and improve its quality. Specialized freemium consultations provided by health care providers via online health informatic platforms are needed to shorten the time for caregivers’ cancer symptom appraisal before the first medical contact.
A Digital Music-Based Mindfulness Intervention for Black Americans With Elevated Race-Based Anxiety: A Multiple-Baseline Pilot Study (Preprint)
Authors: Jones Grant , Herrmann Felipe , Nock Matthew K
Published: August 2023

BACKGROUND

Race-based anxiety is a substantial health issue for the Black community. Although mindfulness interventions have demonstrated efficacy for alleviating anxiety, three central barriers prevent Black Americans from accessing existing mindfulness treatments: high costs, excessive time commitments, and limited cultural relevance. There is a need for novel mindfulness interventions for the Black community that can overcome these barriers.

OBJECTIVE

The goal of this web-based study was to examine the preliminary efficacy, feasibility, and acceptability of a novel digital music-based mindfulness intervention for middle-to-low-income Black Americans with elevated race-based anxiety.

METHODS

This study used a nonconcurrent multiple-baseline design (n=5). The intervention featured contributions from Lama Rod Owens (a world-renowned meditation teacher and LA Times best-selling author) and Terry Edmonds (the former chief speechwriter for President Bill Clinton). We examined the effect of the intervention on state anxiety and assessed its feasibility and acceptability using quantitative and qualitative measures.

RESULTS

Results revealed that administration of the intervention led to significant decreases in state anxiety (Tau-U range –0.75 to –0.38; P values<.001). Virtually all feasibility and acceptability metrics were high (ie, the average likelihood of recommending the intervention was 98 out of 100).

CONCLUSIONS

This study offers preliminary evidence that a digital music-based mindfulness intervention can decrease race-based anxiety in Black Americans. Future research is needed to replicate these results, test whether the intervention can elicit lasting changes in anxiety, assess mechanisms of change, and explore the efficacy of the intervention in real-world contexts.
The burden of disease attributable to dietary risks in China, 1990-2019: a systematic subnational analysis for the Global Burden of Disease Study 2019 (Preprint)
Authors: Wang Wenxiu , Zhuang Zhenhuang , Li Jianhong , Wang Qihe , Qu Pengfeng , Liu Sana , Huang Tao , Liu Aidong
Published: August 2023

BACKGROUND

Temporal trends and geographical variations in non-communicable diseases (NCDs) attributable to suboptimal diets in China have not been systematically investigated.

OBJECTIVE

This study aimed to estimate the disease burden related to major foods and nutrients at national and provincial levels in China from 1990 to 2019.

METHODS

Following the methods of the Global Burden of Disease Study (GBD) 2019, all-cause and cause-specific and province-specific mortality and disability-adjusted life-years (DALYs) burden attributable to diet were comprehensively evaluated across the 33 province-level administrative units in China between 1990 and 2019.

RESULTS

Nationally, in 2019, 2.0 million (95% uncertainty interval [UI]: 1.5, 2.6) deaths and 46.8 million (35.6, 60.0) DALYs were attributable to dietary risks in China, of which cardiovascular diseases accounted for the highest proportion among all cause outcomes (1.7 million [1.3, 2.3] deaths, 39.0 million [29.2, 49.7] DALYs). The age-standardized death and DALY rates associated with dietary risks were 162 (121, 211) deaths per 100 000 population in 1990 and 115 (85, 152) deaths per 100 000 population in 2019, and 3 570 (2 740, 4 544) DALYs per 100 000 population in 1990 and 2 394 (1 823, 3 071) DALYs per 100 000 population in 2019, with percentage change of -28.8% and -32.9% from the 1990’s estimates. High consumption of sodium (855 385 [320 611, 1 546 463] deaths; 21.1 million [35.6, 9.3] DALYs), low consumption of whole grains (383 478 [192 387, 502 816] deaths; 8.6 million [4.6, 11.3] DALYs), and high consumption of red meat (323 380 [204 050, 456 381] deaths; 8.7 million [6.1, 11.8] DALYs) were the leading dietary risk factors for deaths and DALYs of estimated burden in 2019. The burden of disease caused by dietary risks varied substantially across China, with the western and northeastern provinces demonstrating a comparatively high age-standardized rate linked to dietary risks.

CONCLUSIONS

Although the age-standardized death and DALY rates associated with dietary factors have declined since 1990, the impact of suboptimal diet on the burden of NCDs and regional disparities across China remains an important public health concern. The results from our study hold the potential for guiding the development of effective and localized dietary interventions that can enhance the quality of diets and alleviate the burden of dietary-related diseases.
Green Synthesis and Electrochemical Study of Undoped and Doped Al2O3 Nanoparticles Using Hibiscus rosa-sinensis Leaves Extract
Authors: Haider Farzana , Nabi Gul Asimullah Khan , Shah Kiran , Khan Kafeel Ahmad , Khan Haseeba
Published: August 2023

In the present work, nanoparticles of Al2O3, Cu-Al2O3, and Ni-Al2O3 were prepared using Hibiscus rosa-sinensis plant leaf extract through co-precipitation method. The prepared nanomaterials were characterized through TGA, EDX, SEM, UV-Vis, XRD, and FTIR instruments. The electrochemical behavior of Al2O3, Cu-Al2O3, and Ni-Al2O3 has been studied in DMF solution in the potential ranges from −1.5 to 1.5 V. The nanoparticles are thermally stable, according to the TGA, and the XRD patterns revealed that all the Al2O3, Cu-Al2O3, and Ni-Al2O3 particles were crystalline, with the mean sizes of 12.44, 34.61, and 31.63 nm, respectively. The cyclic voltammogram showed a cathodic peak (Epc) at 0.49 V with an anodic counterpart (Epa) at 0.49 V [E1/2 = 1.748 V]. The optical band gaps of Al2O3, Cu-Al2O3, and Ni-Al2O3 were 3.8, 3.2 and 3.65 eV, owed a cathode. It is observed that the electrochemical behavior of Ni-Al2O3 was identical to that of Al2O3 and Cu-Al2O3. The anodic and cathodic peak values rise with the scan rate. The one-electron oxidation and reduction processes are reversible, as seen by the shifting cathodic peak value toward higher negative values. All cycles exhibit absorption has a constant anodic current. This result indicated the diffusion-based redox process.
Fiscal Decentralization and Corruption: The Facts of Regional Autonomy Policies in Indonesia
Authors: Syarif Ahmad
Published: August 2023

Decentralization has posed new problems in Indonesian local governments, including disparities between regions, poor public services, fiscal indiscipline, and corruption cases. Before the implementation of regional autonomy, corruption cases were reported only in a few regions. A year after decentralization started, in 2002, more corruption cases were reported in more regions nationwide. The irony is that such decentralization, initiated to reduce corruption in the government, ended up with more corruption in the regions. This study investigates the relationship between fiscal decentralization—as proxied by capital expenditure and fiscal independence index—and the corruption index. This study also analyzes the macro factors and regional characteristics: inflation, civil servants’ salaries, education levels, and the differences in the corruption index at the regional level. The method used in this study is regression analysis by using panel data from longitudinal studies involving 15 cities in Indonesia in 2008, 2010, 2015, and 2017. The finding shows that the relationship of fiscal decentralization—expenditure, inflation rates, civil servants’ salaries, and local corruption—are not statistically significant to the corruption index. By contrast, the relationship between the fiscal independence index and educational level are statistically significant. The implementation of fiscal decentralization on expenditure increases corruption risks due to ineffective budget management, individual corrupt tendencies, and weak supervision system. Meanwhile, fair allocation of local income can increase public trust and prosperity and lower corruption risks.
TO EVALUATE THE CARDIOPROTECTIVE AND ANTI-OXIDANT EFFECT OF METHANOLIC EXTRACT OF THE LEAVES OF TRIBULUS TERRESTRIS IN WISTAR RATS
Authors: BARAKA BABIKER BASHIR HAROUN , V RAO BHAGYA , PKM NAGARATHNA , JHA DEEPAK KUMAR , VARDHINI N HARSHA
Published: August 2023

Objectives: The aim of the current study was to evaluate the cardio protective and anti-oxidant effect of methanolic extract of the leaves of Tribulus terrestris (TT) in Wistar Rats.
Methods: Extracted leaves of TT were evaluated for cardioprotective and antioxidant activities in in vivo model. Thirty rats were divided into 5 groups. Group I and II served as normal control and disease control (doxorubicin 20 mg/kg I.P.), respectively, while Group III was the treated group with standard drug (vitamin-E 10 mg/kg P.O). Group IV and V served as the test groups, which were pre-treated with 250 mg/kg and 500 mg/kg body weight per day of “TT,” and the treatment was given for 7 days, On the 5th day, doxorubicin was given I.P 20 mg/kg, then 48 h after I.P of doxorubicin, animals were sacrifice and then blood samples was taken for biochemical estimation, and the rat heart for histopathological examination. Along with it, antioxidant studies were carried out using heart tissue homogenate from each group.
Results: The administration of doxorubicin to control group’s rats presented a significant increase in serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein, creatine kinase-MB, serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic-pyruvic transaminase (SGPT), and decrease in high-density lipoprotein (HDL). Rats treated with TT showed decreased TCs, TGs, low-density lipoprotein, CKMB, SGOT, SGPT, and increases HDL levels. The histopathological studies also showed that the TT significantly minimized the damage induced by doxorubicin.
Conclusion: It can be concluded that the TT could be a potential candidate for the treatment of cardiotoxicity.
BIOCHEMICAL PROFILE OF PATIENTS WITH ORGANOPHOSPHORUS POISONING: REPORT FROM A RURAL-BASED TEACHING HOSPITAL IN EASTERN INDIA
Authors: Roy Utsab , Gayen Biplab Kumar , Kar Jugal Kishore , Dhua Aparup , Mahapatra Umakanta , Patra Manas
Published: August 2023

Objective: Organophosphorus (OP) poisoning is a very common form of poisoning, especially in rural areas due to the use of OP poisons for agricultural purposes. There is high mortality and morbidity among patients with a history of consumption of this poison. This study aimed to find various biochemical test parameters among patients with OP poisoning admitted to a hospital in the state of West Bengal, India.
Methods: This was an observational and cross-sectional study and conducted from January 2020 to July 2021. During the study period, any patients admitted to general medicine with a history of OP poisoning were included in the study. Aseptically collected venous blood was collected on admission, 12 h, 24 h, and 48 h of admission and immediately sent to the central laboratory for analysis in an automated analyzer.
Results: A total of 100 patients were analyzed. Among them, 80 patients were alive and 20 patients died. The majority of the patients were young adults (21–30 years [53%]). Among the patients, 64% were male, 91% were rural inhabitants, and 43% were a farmer in the profession. The level of hemoglobin was higher, total WBC count was lower, liver enzymes were lower, and urea and creatinine were lower among the patients who survived. However, the sodium, potassium, and calcium were not significantly different between dead and alive patients.
Conclusion: In the management of OP poisoning, the biochemical profile of blood may help identify the patients at risk, and appropriate management can be started accordingly. The biochemical profile also helps in the prognosis of OP poisoning.
DETECTION OF CARBAPENEMASE-PRODUCING CARBAPENEM-RESISTANT IN BLOOD CULTURE ISOLATES BY MCIM AND ECIM AND ITS SUSCEPTIBILITY TO TIGECYCLINE AND MINOCYCLINE
Authors: Kachari Pushpa , Anuradha K  , C Ravindranath
Published: August 2023

Objective: In this study, we aimed to detect different Carbapenemase-producing carbapenem-resistant Enterobacterales (CREs) in blood isolates by phenotypic, modified carbapenem inactivation methods (mCIM) and amp; EDTA-carbapenem inactivation methods (eCIM), and also to study the susceptibility of these CREs toward Tigecycline and Minocycline.
Methods: This prospective study included 100 non-duplicate Enterobacterales organisms isolated from 250 blood samples positive for Enterobacterales that showed resistance to carbapenem (Imipenem). The isolates were identified by conventional routine biochemical tests. CRE isolates were screened for Carbapenemase production by the Clinical and Laboratory Standards Institute (CLSI)-recommended, mCIM and eCIM for evidence of the production of matello-beta-lactamase. Antimicrobial susceptibility for Tigecycline and Minocycline drugs was tested by the disk diffusion method on Mueller–Hinton agar according to CLSI guidelines, and susceptibility patterns were recorded. Clinical diagnosis data were collected from the requisition forms sent to our laboratory during test procedures.
Results: Out of 100 (40%) CRE isolates tested for mCIM, 34 samples showed positive results for the Carbapenemase enzyme. Among the mCIM-positive isolates, Klebsiella spp. showed the highest prevalence of 58.8% (20/34). While among mCIM-positive isolates (22/34), 64.7% were positive for eCIM (Matello beta-lactamase producer). Maximum samples had been received from the NICU ward from patients diagnosed with early-onset sepsis; 41.2% of these were Carbapenemase-producing Enterobacterales. Among CRE isolates, 86 isolates were susceptible to Tigecycline and 24 isolates were susceptible to Minocycline. 70 CRE isolates were susceptible to Tigecycline but resistant to minocycline, and all CRE isolates resistant to Tigecycline were not susceptible to Minocycline.
FREQUENCY OF CLAR AND JAK2 MUTATIONS IN SUDANESE CHRONIC MYELOID LEUKEMIA PATIENTS WITH PHILADELPHIA-POSITIVE DISEASE
Authors: Yasin Elrashed B , Yasin Aymen
Published: August 2023

Background: It is well-established that myeloproliferative diseases coexist with CLAR and JAK2. In Ph+ chronic myeloid leukemia (CML), only a few case reports indicate the existence of CLAR, JAK2V617F, and JAK2 exon 12 mutations.
Methods: This study examined CALR and JAK2 mutation profiles in Sudanese Chronic Myeloid Leukemia patients with Philadelphia-positive patients. Blood samples were collected from 100 patients with Ph+ CML chromosomes. Results for the JAK2V617F mutation were confirmed using the TaqMan® Mutation Detection Assay, and the four common mutations on exon 12 and CLAR mutations were confirmed using allele-specific PCR (AS-PCR) and Sanger sequencing.
Results: CML patients with CALR frameshift mutations were detected in two patients (2%), patients with JAK2 exon 12 mutations were found in two patients (2%), and patients with JAK2V617F mutations made up 4 (4%) of the total CML patients. No significant relationships existed between mutations and age, WBC, RBC, Hb, HCT, or platelet parameters. Patients with CLAR, JAK2 exon 12, and JAK2V617F mutations have normal leukocyte counts and lower values compared to triple-negative Ph+ CML, but these differences are not statistically significant (p values for each 0.084, 0.173, and 0.072).
Conclusion: It is conceivable for Ph+ CML and all mutations to coexist.
FETOMATERNAL OUTCOME OF GESTATIONAL DIABETES MELLITUS IN PRIMIGRAVIDA DELIVERED AT TERTIARY CARE HOSPITAL
Authors: Vishnoi Nirmla , Jakhar Rekha , Choudhary Ankita , Bharia Monika
Published: August 2023

Objective: To determine the Prevalence of gestational diabetes mellitus (GDM) in primigravida and their feto-maternal outcome who delivered at tertiary care hospital in western Rajasthan.
Methods: A retrospective chart review study will be conducted on primigravida delivered at the department of Obstetrics and Gynaecology, MDM Hospital Dr. S. N. Medical College, Jodhpur, Rajasthan, India from May 2022 to December 2022.
Results: The prevalence of GDM in primigravida was 6.42%, maximum occurrence between 34 and 36 weeks of gestation (53.3%). 8.8% of GDM patients had a preterm delivery, out of these 8 women polyhydramnios were seen in 4 women. 49% had lower segment cesarean section and 3% had instrument delivery. preeclampsia was seen in 25.56%, urinary tract infection in 10%, preterm labor was seen in 8.89%, premature rupture of membrane was seen in 5.56% of the study population. 10% of babies were low birth weight. The incidence of congenital anomalies was seen in 6.6%. Intrauterine death was seen in 2 babies who had congenital anomalies.
Conclusion: GDM is associated with adverse complications in both the mother and fetus.
Geospatial Analysis of Irrigation Challenges and Opportunities in Jharkhand
Authors: Shukla Rajkaran , Singh Surajbhan
Published: August 2023

Agriculture has been the principal livelihood alternative of mankind to begin stationary human development and water was of primary significance for field crops after soil. Customary watering of plants gave enlargement of homestead items, which lead to the introduction of the possibility of irrigation. Steadily the procedures of irrigation advanced from customary to present day with proper method of time diffused various pieces of the world. Irrigation is characterized as the counterfeit utilization of water to soil for consistently providing the dampness basic for plant development. It achieved in various ways by flooding, wrinkles, spreading, by applying water underneath the land surfaces by sub-irrigation. Irrigation is firmly identified with various physical and social viewpoints. Indian agriculture history goes back to certain centuries and Chakulia, has been rice bowl for Jharkhand. Ranchi is one of the most famous city and district of Jharkhand. From the goes back, the economy of the district was agrarian and irrigation was the parts and package of the livelihood of the general population. The present research has been completed dependent on issues and prospects of irrigation in the district. The prime goals of the study are I) Finding out the determinants of irrigation, ii) Examining the Spatio-worldly variety of irrigation, iii) Exposing the effect of irrigation on agriculture and economy of the rancher, iv) Identifying the issues identified with irrigation in the district and v) studying the irrigation accessibility both surface and ground water in the district.
Thematic Concern and Technical Features in Karnad’s Tale-Danda
Authors: Manju Manju , Singh Dr. Nempal
Published: August 2023

Girish Karnad, a writer, explores Kalyan-Kranti's last days in his play Tale-danda. Girish hopes to draw attention to the divisions in Indian society and government. The centuries-old societal problem of caste is given the attention it deserves. Sharana's effort to outlaw it was brought to life. The plot revolves on the unconventional union of a Brahmin bride and a Cobbler groom. The failed marriage and its aftermath highlight the crude nature of the caste system. Sovidev's political plotting against his own father, Bijjal, is emblematic of the universal lust for power. Karnad brilliantly illustrates the social and political tensions of modern civilization by merging these two subjects.
Reflexiones éticas y políticas de filosofía desde un horizonte propio
Authors:   Centro de Investigaciones sobre América Latina y el Caribe, Magallón Anaya Mario
Published: August 2023

Hoy más que nunca es necesario considerar el papel que desempeñan las humanidades y las ciencias sociales y naturales en el replanteamiento de un proyecto global mundializado, en el que los principios de las relaciones sociales, de laética, de los derechos humanos, de la política, de la economía, de la ciencia sean el resultado de un proceso de investigación, de diálogo, de discusión y de análisis crítico, para asumir compromisos y responsabilidades con los setes humanos concretos e históricamente situados.
América Latina y la filosofía de la historia
Authors: Mateos Castro José Antonio
Published: August 2023

En un momento de crisis económica mundial, desde el Sur, donde las maquiladoras no duermen, donde la gente vende diarios que no sabe leer, cose ropas que no puede vestir, pule autos que no son ni serán de su propiedad, y levanta edificios que jamás habitará; se hace necesario plantear una filosofía de la historia abierta, "desde abajo", que justifique el ingreso a la Historia de los diferentes, de los sin-nombre, de los silenciados y, que actualice la memoria de un continente que aún tiene las "venas abiertas" y no acaba de ser plenamente nuestro.
Tendencias de clima laboral 2017 en empresas de servicios varios de Manzanillo, Colima, México
Authors: Jover Jiménez Isabel Felicita , Francisco González Renato
Published: August 2023

El presente estudio descriptivo – analítico, de corte triangular responde al objetivo de evaluar el clima organizacional en 18 empresas de Manzanillo representativas de 1005 colaboradores; a través de 479 encuestas, para un 48 % de representatividad muestral. Analizándose el comportamiento de 13 variables: (empresa, condiciones ambientales, ergonomía, creatividad e iniciativa, motivación, comunicación, reconocimiento, integración y trabajo en equipo, compañeros de trabajo, jefe y superiores, remuneración, puesto de trabajo y calidad), con 64 indicadores. Utilizados los métodos estadísticos: Análisis de componentes principales y ANOVA; alcanzando resultados que originaron estrategias y propuestas de mejora a tono con las oportunidades identificadas.
La migración centroamericana hacia Estados Unidos y México: ¿A qué mundo se enfrentan?
Authors: Barrón Pérez María Antonieta
Published: August 2023

El aumento de la migración en el mundo y hoy de centroamericanos, es resultado de la violencia, el desempleo, el bajo crecimiento económico, en suma, de la profunda crisis económica y social resultado de los cambios estructurales del modelo neoliberal. La migración de centroamericanos hacia México con la esperanza de pasar a los Estados Unidos es una respuesta a esta situación, pero ¿cuáles son los resultados de esta migración?
Ante la complejidad del fenómeno en este trabajo se pretende analizar la tendencia de las migraciones de tres países, Honduras, El Salvador y Guatemala, que hoy son los más importantes flujos migratorios que llegan a México y plantear las consecuencias para ellos; si se quedan en México, se enfrentan al desempleo o bien a mercados de trabajo precarios y vulnerables.
Globalización entre muros y fronteras: Escenario de la migración internacional
Authors: Roldán Dávila Genoveva
Published: August 2023

En los últimos cuarenta años, en el contexto de la globalización capitalista, diversos procesos han adquirido nuevas expresiones. En este artículo nos proponemos analizar, desde la heterodoxia, cuál ha sido el papel que han jugado las migraciones internacionales en el proceso de globalización y su vínculo con las características de la desterritorialización de las fronteras. A partir de lo anterior, se identifican las articulaciones y paralelismos de la “crisis migratoria” que ha alcanzado gran connotación en la Unión Europea y en el sistema migratorio Estados Unidos-México, Centroamérica, con la crisis sistémica que detonó en 2008, también reconocida como crisis civilizatoria por su carácter multidimensional.
Prediction of Learning Disability Using Machine Learning
Authors: Ravindran Anjana V , J Anjana V , P Meenakshi
Published: August 2023

Abstract: This A learning disability is a neurological disorder. The children predicted with learning disability may find it difficult to spell, read, write, organize things and so on. Learning disabilities are not related to intelligence or motivation. People with learning disabilities have average or above-average intelligence but may need special accommodations and support to learn and succeed. Early identification, assessment, and intervention are critical for managing learning disabilities. With appropriate support and accommodations, people with learning disabilities can achieve their full potential and lead fulfilling lives. Machine Learning algorithms can be useful in predicting learning disabilities because they can analyse large amounts of data quickly and accurately, and they can identify patterns that may not be apparent to human observers. Deep learning models can lead to better and faster predictions and they are capable to work with unstructured data as well. While Machine Learning and Deep Learning algorithms have shown promise in predicting learning disabilities, it’s important to use these tools in a responsible and ethical manner to ensure that individuals’ privacy and autonomy are protected. By leveraging the power of these algorithms, we can help to ensure that children with learning disabilities receive the support they need to reach their full potential. In this study, six models, ANN and CNN, were assessed for their effectiveness in predicting specific learning disabilities. The performance measure used to evaluate the models was accuracy. Among the models, KNN is found to be the most accurate with 90.33% followed by Random Forest with 79.22%, CNN with 77.69% LSTM with 77.57%, ANN with 57.57% and SVM with 57.57%.
Pancreatic Perivascular Epithelial Cell Tumor (PEComa) with Liver Metastasis: a Case Report and Literature Review
Authors: Stepanova Yu. A. , Ayvazyan Kh. A. , Kalinin D. V. , Zhavoronkova O. I. , Shirokov V. S. , Zhao A. V.
Published: August 2023

Aim: to present a clinical case of pancreatic PEComa with liver metastases with an emphasis on morphological features, radiology diagnostic methods and features of treatment tactics, allowing practitioners to get an idea about this rare mesenchymal tumors composed of “perivascular epithelioid cells”, and a review of literature data on pancreatic PEComa, including 32 author's cases.

General statements. A 22-year-old woman who was surgically treated for pancreatic head PEComa with infiltration of the duct of Wirsung, common bile duct, duodenal wall, focal invasion into the blood and lymphatic vessels, and perineural space infiltration. Synchronously, metastases were detected in both liver lobes, for which she took Everolimus for 6 years under the control of radiology methods with dose adjustment and frequency of administration. At the A.V. Vishnevsky National Medical Research Center of Surgery, the patient underwent right-sided hemihepatectomy and atypical resection of II-III liver segments.

Conclusion. To determine clearer criteria for the diagnosis and differential diagnosis of PEComa, to identify criteria for the malignancy of these tumors, to develop treatment tactics and further dynamic monitoring, a set of statistical data of significant group and randomized clinical trials are needed. Pancreatic PEComas in this group are extremely rare and often have a benign course. The presented clinical case demonstrates the most malignant form of this tumor with localization in the pancreas and liver metastases.
Phenotypes of Non-Alcoholic Fatty Liver Disease in Different Regions of the Russian Federation, Diagnostic and Therapeutic Approach in Clinical Practice
Authors: Ivashkin V. T. , Zharkova M. S. , Korochanskaya N. V. , Khlynov I. B. , Uspensky Yu. P.
Published: August 2023

Aim: to present data on the prevalence of various phenotypes of non-alcoholic fatty liver disease (NAFLD), the features of its diagnosis and treatment in various regions of the Russian Federation following a meeting of chief gastroenterologists.

Key points. Non-alcoholic fatty liver disease (NAFLD) holds the leading position among non-infectious liver diseases in the Russian Federation, its prevalence is 37.3 % and does not tend to decrease.

To get information on various aspects of NAFLD diagnosis and treatment, opinion of 18 chief external regional gastroenterologists and leading specialists in the field of liver diseases was studied by analyzing the responses to questions specially formulated for them. Information on the situation in the Ural, Privolzhsky, Southern, Central and North-western Federal Districts was obtained. Regional statistics on the prevalence of NAFLD and its certain phenotypes (steatosis, steatohepatitis, cirrhosis), diagnostic instruments and treatment approaches which are used in clinical practice, as well as on the most common associated conditions was presented.

Conclusions. The collected information allows to improve both administrative and treatment and diagnostic-related activities in managing patients suffering from this disease.
Enkripsi Data Teks Dengan AES dan Steganografi DWT
Authors: Umam Chaerul , Muslih Muslih
Published: August 2023

Pertukaran data melalui internet rawan akan adanya pencurian informasi. Maka dari itu, sebagai upaya pencegahan terjadinya hal itu diperlukan sebuah sistem keamanan. Terdapat berbagai macam usaha perlindungan suatu data, misalnya dengan menggunakan teknik kriptografi dan steganografi. Pada penelitian ini, membahas bagaimana hasil data teks yang telah dienkripsi menggunakan algoritma Advanced Encryption Standard (AES) 128-Bit dilanjutkan dengan teknik steganografi pada sebuah citra menggunakan algoritma Discrete Wavelet Transform (DWT). Kemudian data hasil percobaan dianalisis kualitasnya menggunakan parameter Mean Signal Error (MSE) dan Peak- to-peak Signal to Noise Ratio (PSNR) sebagai alat ukurnya. Pada percobaan ini kualitas gambar stego menggunakan DWT tergolong cukup baik dengan menghasilkan nilai MSE 0.16-0.26 dB dan nilai PSNR nya 46.27-52.2 dB.