bluuebunny/crossref_metadata_2025 huggingface dataset:
Trigger Point Injection Therapy in the Management of Myofascial Pain Syndrome in the Maxillofacial Area
Authors:   Center for Advanced Training of Medical Specialists, Arsenova I.A. , Pohodenko-Chudakova I.O. ,   Novosibirsk, Belarusian State Medical University, Lar’kina M.A. ,   Dental Clinic "Dentaliya-Blesk
Published: January 2021

Цель. Оценить эффективность инъекций в триггерные точки при лечении миофасциального болевого синдрома челюстно-лицевой области. Материал и методы. С 2014-2017 гг. было пролечено 124 человека с миофасциальным болевым синдромом лица, из них 76 женщин и 48 мужчин в возрасте от 19 до 62 лет. Кроме клинических и рентгенологических методов диагностики всем пациентам выполняли электромиографию и тестирование болей по визуальной аналоговой шкале боли (VAS). С целью купирования миофасциального болевого синдрома применялись методы традиционной терапии: шиновая терапия, коррекция окклюзии, медикаментозная и физиотерапия. При неэффективности традиционных методов выполнялись инъекции «Лимфомиозот» и «Траумель С» в триггерные точки по методике J. Kersschot (2010). Контрольные осмотры проводились через 1, 3, 6, 12 и 18 и 24 месяца после выполнения манипуляции. При контрольных осмотрах обращали внимание на жалобы пациентов, определяли интенсивность боли по VAS. Критерием положительных результатов лечения являлось отсутствие болей в покое и при функциях. Результаты. При стандартном лечении положительные результаты были получены у 86 из 124 человек (69,4%). Инъекции в триггерные точки, выполняемые при недостаточной эффективности лечения у 38 человек, привели к прекращению боли у 32 (84,2%) пациентов. Как показали наши наблюдения, длительный период без боли (в течение двух лет) наблюдали у 12 (37,6%) человек. Продолжительный эффект в течение периода времени до полутора лет был констатирован у 8 пациентов (25%), до 1 года – у 7 человек (21,8%), до 6 месяцев – у 5 (15,6%). Заключение. Инъекции в триггерные точки повышают эффективность терапии и обеспечивают длительный период ремиссии заболевания, что проявляется в отсутствии болевых приступов и ощущения дискомфорта. Научная новизна статьи Впервые для лечения миофасциального болевого синдрома (МБС) лица была использована методика с применением инъекций «Лимфомиозот» и «Траумель С» в триггерные точки. Установлено, что данная методика инъекций в триггерные точки является эффективным методом лечения МБС лица в независимости от причины, его вызвавшей. Показано, что применение инъекций в триггерные точки при миофасциальном болевом синдроме лица способствовало быстрому купированию болей и длительному безболевому периоду сроком наблюдения до двух лет.
Biomarkers of Hypoxic-Ischemic Encephalopathy in Newborns
Authors: Noorishadkam Mahmood , Savabieh Shekoofeh , Sharifi Mohammad Emad
Published: January 2021

Biomarkers are particles that are released from target organs during tissue hypoxia injury. Recognizing biomarkers released from the damaged brain helps physicians determine the extent of tissue damage and the use of protective techniques in clinical treatment.  Previous studies revealed that biomarkers such as brain-specific proteins (neuron-specific enolase (NSE), S100B, ubiquitincarboxy-terminal hydrolase-L1, total Tau) and cytokines, including IL-6, IL-1β, IL-10, IL-13, interferon-gamma, TNF alpha and brain-derived neurotrophic factor are useful in diagnosing hypoxic-ischemic encephalopathy (HIE) and predicting nerve growth outcomes. However, optimal sensitivity and specificity of these biomarkers have not been achieved, which has limited their clinical application. This review focuses on biomarkers such as lactate, LDH, NRBC, NSE, S100B, GFAP, CPK-BB, IL-6, NPBI, UCHL-1. More sensitive and accurate instruments such as brain imaging (such as brain MRI), brain function (such as NIRS, aEEG), and long-term neuroassay should be used in the future to confirm biomarkers of neonatal brain damage.
Aula de português na educação superior: Um olhar para a aprendizagem significativa
Authors: Luciani Luciana Paula Bento
Published: January 2021

Independentemente da disciplina que se ministra, é possível provocar discussões em prol de uma aprendizagem significativa. Certamente alguns conteúdos são mais propícios que outros. Além disso, de modo geral, disciplinas e conteúdos direcionados ao futuro campo de atuação profissional tendem a atrair mais o interesse e a participação dos alunos. Com base nesses pressupostos, este artigo apresenta um relato de experiência e discute os resultados alcançados com a aplicação de uma atividade que teve como objetivo promover o desenvolvimento das quatro habilidades necessárias à competência interativa e comunicacional, conforme Irandé Antunes (2016): ler, escrever, falar e ouvir – fundamentais para toda e qualquer atuação cidadã e profissional. Tal proposta foi apresentada na disciplina de Redação Comercial I, ministrada para alunos do primeiro semestre do curso de graduação em Administração de Empresas, de uma Instituição de Ensino Superior da cidade de São Paulo. A atividade elaborada para essa referida turma parte da técnica “pequenos grupos para formular questões”, proposta por Masetto (2003, p. 119), e termina com a escrita e reescrita de um artigo de opinião. Dessa forma, pretende-se mostrar, ainda, como, a partir de uma técnica interativa e de materiais que fazem parte do cotidiano social e profissional dos alunos, foi possível propiciar um estudo efetivo da língua da materna.
Principais motivadores de desvios ortográficos no ensino fundamental
Authors: Lourenço Naira Cristina Sarturi de Melo , Bertucci Barbosa Juliana
Published: January 2021

Os desvios ortográficos na linguagem escrita são comuns no ensino fundamental. Sejam eles motivados pela fala ou pela convenção ortográfica é importante o desenvolvimento de um trabalho de análise desses desvios e a elaboração de atividades de adequação à linguagem escrita. Este trabalho pretende analisar os desvios ortográficos, observando os processos fonológicos presentes na escrita de textos de alunos do 6º ano do Ensino Fundamental de uma escola pública urbana do município de Aguaí, interior de São Paulo, para posterior tomada de decisão na elaboração de atividades para superação desses desvios na linguagem escrita. Foi utilizada a pesquisa quantitativa, com mapeamento das irregularidades ortográficas através de tabelas indicativas da motivação do desvio apresentado, classificadas em duas categorias: a das provenientes de convenção ortográfica ou dos hábitos da fala (Bortoni-Ricardo, 2005); e qualitativa, uma vez que foram feitas análises dos dados coletados. Através da pesquisa pôde-se observar que os desvios mais recorrentes na escrita dos alunos do 6º ano de uma escola pública urbana do município de Aguaí-SP têm motivação na transposição da fala para a escrita. Assim, a prática pedagógica para aquisição da linguagem escrita deve estar pautada no estudo da linguagem oral, suas possibilidades e a adequação para a linguagem culta escrita. Dessa forma, é imprescindível o respeito às diversidades socioculturais no trato com os discentes, de forma que sejam acolhidos no ambiente escolar e não limitados pela imposição da norma culta.
Efecto de la adición de subproductos agroindustriales en las propiedades físicas de un biopolímero almidón-gelatina
Authors: Salazar López Ricardo , Francisco Ponce Blanca Aurora , Vidal Silva Isamar Maydeth , Maldonado Astudillo Yanik Ixchel , Jiménez Hernández Javier , Flores Casamayor Verónica , Arámbula Villa Gerónimo
Published: January 2021

En este trabajo se reporta el efecto de la adición de subproductos de mango, jamaica y café a una formulación de almidón-gelatina para elaborar una bioplástico en forma de cuchara. Se encontró que la adición de los subproductos mejoró las propiedades mecánicas del bioplástico debido a la compatibilidad de sus componentes observados a nivel microscópico (la dureza aumento de 190 hasta 290 N). Asimismo, las propiedades físicas de los bioplásticos como el ángulo matiz (63-89), y los índices de solubilidad y absorción en agua se modificaron por la adición de subproductos. Se observó que las condiciones de máxima estabilidad de los bioplásticos obtenidas a partir del modelado de las isotermas de adsorción a 35 °C con la ecuación de GAB y el cálculo el volumen de microporo correspondieron a una actividad de agua cercana a 0.40, independientemente del subproducto agregado.  Las distintas formulaciones exhibieron un evento endotérmico a una temperatura de 180ºC, asociado a un proceso de fusión, así como una elevada tasa de degradación en suelo después de 120 h. Los subproductos probaron ser un refuerzo en la formulación de bioplásticos. El uso de subproductos de mango, café y jamaica representan una alternativa interesante para incrementar su potencial tecnológico.
Cocción tradicional con especias de Phaseolus vulgaris L. y su efecto antinutricional e inhibición bacteriana
Authors: Olivas Orozco Guadalupe Isela , Lamz Piedra Alexis , Cázares Chávez Zulema , Jiménez Galindo José Cruz , Molina-Corral Javier , Sepúlveda David , Rios-Velazco Claudio
Published: January 2021

En el presente trabajo se estudió el efecto del uso de métodos tradicionales para la cocción del frijol: remojo, cocción en olla de barro o de presión, y adición de especias (laurel o epazote). Con respecto al ácido fítico, los resultados muestran que la cocción en olla de presión con previo remojo, es el método que disminuye en mayor proporción la concentración de este factor antinutricional. Para la disminución de α-oligosacáridos rafinosa y estaquiosa, el remojo es el tratamiento que da una mejor respuesta para disminuir los α-galactosacáridos. La cocción en olla de barro disminuye considerablemente estos compuestos en comparación con el uso de olla a presión. El uso de hojas de epazote y de laurel fue muy efectivo para disminuir la concentración de oligosacáridos, además de inhibir el crecimiento microbiano. Por otro lado el uso de presión en la cocción fue el más efectivo para la disminución de la actividad de los inhibidores de tripsina. Una combinación de cocina tradicional mexicana (uso de especias) y cocina moderna (olla a presión) es la mejor manera de disminuir los compuestos antinutricionales y preservar la calidad microbiana de los frijoles cocidos. Estos resultados muestran la importancia de estudiar y preservar la cocina tradicional mexicana.
Actividad de extractos de plantas y hongos entomopatógenos para el control del picudo de la guayaba (Conotrachelus dimidiatus Champion) Coleóptera: Curculionidae
Authors: Delgado-Ortiz Juan Carlos
Published: January 2021

El picudo de la guayaba es el principal problema fitosanitario, ocasionando pérdidas del 60% en la producción; el principal método de control del picudo de la guayaba es la aplicación de insecticidas químicos como el paratión metílico y el malatión. El objetivo del estudio fue evaluar la eficiencia de hongos entomopatógenos en combinación con diferentes extractos vegetales en el control de Conotrachelus dimidiatus. En el presente estudio se evaluó la efectividad biológica de cepas nativas de Beauveria bassiana y Metarhizium anisopliae, la susceptibilidad del picudo de la guayaba a extractos vegetales, así como la compatibilidad de B. bassiana y M. anisopliae con los extractos vegetales para el control del picudo. Se calculó la CL50 de las cepas que presentaron mayor patogenicidad sobre los adultos de C. dimidiatus; posteriormente estos fueron expuestos a las CL50 y concentraciones subletales de los extractos. Los resultados demostraron que las cepas de B. bassiana fueron patogénicas para el insecto. El extracto de pimienta y semilla de jícama mostraron actividad insecticida. Las mezclas entre los hongos y los extractos registraron mortalidades del 90 %.
Dodatek kwartalny
Authors: Paduszyńska Marta , Lasek Jagoda , Konopacka Joanna , Jurek Michał , Witczak Radosław
Published: January 2021

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Evaluation of Seasonal Differences in the Antioxidant Activity of Needle Juices of Picea abies L. and Pinus sylvestris L. with Luminol-enhanced Chemiluminescence
Authors: Bushmeleva K.N. , Vyshtakalyuk A.B. , Terenzhev D.A. , Nikitin E.N.
Published: January 2021

Background: Coniferous tree species typical of the central part of Russia can be evaluated not only as sources of wood but also as a raw material for obtaining biologically active substances. Methods: A comparative evaluation of needle juices of Pinus sylvestris and Picea abies in the summer and winter periods was the objective of this study and carried out in this study by chemiluminescence analysis and testing for membrane-protective activity. Juices were evaluated for the content of flavonoids and ascorbic acid, which some authors suggest are markers of stress in plants. An increase in the content of flavonoids and ascorbic acid in Pinus sylvestris L. in the summer period is a sign of an adaptive reaction of plants to the high intensity of ultraviolet radiation, which is typical for the growing conditions of pine as a photophilous plant. An increase in these indicators in Picea abies L. in winter is a sign of the plant stress response to low temperatures. Result: The membrane-protective activity of needle juices concerning peroxidation and osmotic hemolysis was revealed, which is more prominent in Pinus sylvestris L. needle juice. The analysis revealed more prominent antioxidant properties in the juice of Pinus sylvestris L. needles compared to that of Picea abies L. both in summer and in winter.
Note sur un essai d'utilisation d'un substitut de sérum pour la croissance des mycoplasmes
Authors: Bréard Alain
Published: January 2021

Un produit de synthèse (Basal medium supplementation, BMS) a été utilisé comme substitut de sérum lors de cultures de mycoplasmes. En milieu gélosé, les colonies deviennent atypiques; en milieu liquide, l'examen microscopique ne montre que des éléments coccoïdes et la croissance est moindre, quantitativ ement, par rapport aux milieux contenant un sérum animal. Après la dixième subculture, lors d'un passage sur milieu traditionnel, les bactéries retouvent toutes leurs caractéristiques. Grâce à sa composition connue, ce substitut de sérum devrait pouvoir être utilisé pour des études fines des mycoplasmes (en biologie moléculaire par exemple), mais il n'est pas conseillé pour l'isolement des souches ou la production d'antigènes.
Epidémie de listériose observée chez des bovins au Nigeria
Authors: Akpavie S.O. , Ikheloa J.O.
Published: January 2021

Une épidémie de listériose, accompagnée de mortinatalité, d'avortements, de signes d'atteinte du système nerveux et de mortalité a été observée dans un troupeau de bovins. L'histopathologie n'a pas révélé de micro-abcès cérébraux typiques, mais l'existence d'une méningite purulente très importante. L'examen bactériologique a permis d'isoler Listeria monocytogenes en culture.
Etude comparative des populations de tiques sur des bovins Goudali et Wakwa dans un parcours naturel infesté de la zone sub-humide du plateau de Wakwa, Cameroun. Observations préliminaires
Authors: Tawah C.L.
Published: January 2021

L'objectif de l'étude était de déterminer la résistance aux tiques des races Goudali et Wakwa respectivement pure sang zébu et demi-sang Brahman. Cinq taurillons de chaque race ont été mis dans un même parc pendant les mois de juillet-août. Les dénombrements de tiques ont été effectués chaque semaine pendant un mois par stade, espèce et sexe. Les résultats ont montré que les espèces adultes recueillies étaient, par ordre décroissant d'abondance : Amblyomma variegatum, Rhipicephalus lunulatus et Hyalomma spp. Les taurillons Wakwa présentaient davantage de tiques que les Goudali (en particulier A. variegatum et Hyalomma spp.) sans que cette différence soit statistiquement significative. La signification d'une variabilité intra-raciale montre qu'une sélection pour la résistance aux tiques, surtout Amblyomma variegatum, pourrait être effective. Ces observations indiquent clairement qu'une étude de plus longue haleine serait nécessaire pour déterminer l'importance réelle de la différence de populations de tiques observée chez les deux races bovines, pour évaluer les mécanismes biologiques de résistance à Amblyomma variegatum et pour estimer l'héritabilité de la résistance aux tiques.
Modern approaches to social and pedagogical support of disabled children and their families
Authors: Boldina Marina A. , Deeva Elena V. , Shadsky Oleg G.
Published: January 2021

We discuss modern approaches to social and pedagogical support of disabled children and their families. Based on modern statistical data and an analysis of its dynamics in recent years, the deterioration of the situation with child disability in the Russian Federation is indicated, which inevitably actualizes the state social policy in this area. The legal framework for recognizing a child as a disabled person and his subsequent social protection is analyzed. A reasonable conclu-sion is made about the insufficiency of an exclusively legislative approach to social support of a disabled child. It is determined that disabled children are children with various mental or physical abnormalities that cause developmental disorders that prevent children from living a full life. Dis-abled children as a social category need social protection, help, support. The leading position in the upbringing, socialization, meeting needs, education, career guidance of a child with develop-mental problems is held by the family. Problems, features, functions of the family of a disabled child are identified. Activities to assist parents in raising a disabled child are one of the most im-portant areas of social and pedagogical support. The concepts of social support, social and peda-gogical support of disabled children are analyzed. We give definition of social and pedagogical support, considered as a set of measures aimed at: social and communicative development of children; development of cognitive mental processes in disabled children; physical development of disabled children and emotional-volitional development. It is concluded that properly organized social and pedagogical support effectively helps disabled children acquire the qualities necessary for their functioning in society, develop social communication, receive education.
Ideal type of personality as system formative factor of national state ideosystem
Authors:   Order Zhukov Military University of Radio-Electronic Systems, Pogorely A.P.
Published: January 2021

Discussed is ideology as ideo-system, in what ideal personality type is system-forming factor. Examples of educational systems in Sparta (Agoge) and Athens (Paideia) confirm this idea. Russian history presents the phenomenon of “Domostroi” as a similar example. Closer confirmation of this phenomenon is “Moral code of the Builder of communism”. Ideal personality type formed in modern Russia is inferior to the Soviet one in objective characteristics. New amendments to the Constitution of the RF in the future should lead to the fact, that the country should create a system of education and upbringing that can form an ideal personality type, corresponding to spiritual and moral code of our people.
Development of tools for practical stage of professional evaluation of qualifications: experience of support in the field of nanotechnologies
Authors:   amara branch of Russian Presidential Academy of National Economy and Public Administration, Golub G.B. , Fishman I.S.
Published: January 2021

Researched is the problem of improving the quality of assessment tools, as the main task of current stage of development of independent assessment of qualifications. The experience of evaluating assessment tools shows, that a number of them violate qualimetric principles of standardized assessment and requirements set by regulators of independent assessment of qualifications system. i.e. the Ministry of Labor and social protection of the Russian Federation and the National Agency for Development of Qualifications. The article presents and discusses typical difficulties of developers of assessment tools for independent assessment of qualifications, and provides recommendations for their prevention. The procedure and basic steps of developer of assessment tools for professional exam are proposed, i.e. unification of the content, development of evaluation criteria, and unification of the evaluation procedure.
Problem of Internet dependence in school, youth and adult midst
Authors:   Kurgan State University, Zakharova E.M. , Bernikova S.M. , Bakina M.I. , Andreeva M.V.
Published: January 2021

Researched is the problem of Internet addiction among users of Kurgan region in age range from 13 to 60 years in comparative aspect. In literature review of the problem, the main types of Internet addiction, its symptoms, negative consequences, and prevention directions are considered. Based on diagnostic methods of L.N. Yurieva and T.Yu. Bolbot, as well as Kimberly Young, 109 respondents were tested for Internet addiction. Comparative characteristics of various indicators of Internet addiction in three age categories are presented: schoolchildren (13–18 years old), students (19–30 years old) and adult users (31–60 years old). The study showed that the majority of Internet addicts are in youth age category (50%), 30% of school children are covered by Internet addiction, and there is no Internet addiction in adult environment. At the same time, the second stage of Internet addiction, that requires therapeutic measures, is also more pronounced in the youth environment (10%), in the school environment of such users are only 2%. The hobby stage is more typical for adult users (83%), 64% of school children are engaged in it, and 20% of young people are engaged in it. The following types of preferences prevail among dependent users: self-addiction in 47%, dependence on social networks in 42%, cyber-addiction (computer games) in 11%
Value and significance of the discipline “Foreign language” within formation and content of modern system of professionally oriented education at the initial stage
Authors:   Lomonosov Moscow State University, Borisenko T.I.
Published: January 2021

Researched are the old problems and new challenges in professional language acquisition regarding social sciences in mass communication of the information society. The preparatory stage is designed for an individual entering the chosen social activity. Systematic bilingual strategies in reading and speaking ensure sustainable progress for personal and social wellbeing. The methodology of teaching is based on the underlying correlation between subject language philosophy and rhetoric. These methods intend to allow a student to adapt to higher education system to continue to learn the content of a basic education science in a native language at the same time to receive foreign language instructions. A bilingual education approach is certainly temporal. Anyway the climax point of language teaching is envisaged to create cross contextual skills to meet qualification requirements to stay afloat in profession via education.
Value of internet resources on stage of modern training in foreign languages
Authors:   Kemerovo State Universit, Mityakina O.V. , Monastyrskaya E.A. , Silkova M.A.
Published: January 2021

Shown is experience of using Internet resources in training students in foreign language. The relevance of using information environment in teaching foreign languages is due to forced distance learning. To activate the cognitive interest and develop communicative abilities of students in non-linguistic areas, advisable is to use project methods. Mandatory condition is the appeal of participants in educational environment to social networks, they enable online communication with native speakers. The E-mail project is considered as a means of implementing linguo-culturological approach in teaching a foreign language. The article describes two methodological tasks of project activity in the aspect of cross-disciplinary connections. The authors note the effectiveness of using the electronic information environment for training students in English.
Workshop for the Assessment of Social-Emotional Competences : Application of SEC-I and SEC-SJT
Authors: Schneider Sarah , Wolf Daniel , Schütz Astrid
Published: January 2021

The modular workshop offers a science-based introduction to the concept of social-emotional competences. It focuses on the psychological assessment of such competences in in institutions specialized in the professional development of people with learning disabilities. As such, the workshop is primarily to be understood as an application-oriented training programme for professionals who work in vocational education and use (or teach the usage of) the assessment tools SEC-I and SEC-SJT (Inventory and Situational Judgment Test for the assessment of social-emotional competence in young people with (sub-) clinical cognitive or psychological impairment) which were developed at the University of Bamberg. The workshop comprises seven subject areas that can be flexibly put together as required: theoretical basics and definitions of social-emotional competence, the basics of psychological assessment, potential difficulties in its use, usage of the self-rating scale, the situational judgment test, the observer-rating scale, and objective observation of behaviour. The general aim of this workshop is to learn how to use and apply the assessment tools in practical settings.
Complexidade enunciativa em memórias da Emília
Authors: Santos Aline Suelen , Jurado Filho Lourenço Chacon
Published: January 2021

Este artigo analisa um recorte da complexidade enunciativa da narrativa Memórias da Emília (1939 [1969]). Essa análise tem como objetivo descrever em que planos dessa complexidade deslocamentos do locutor-narrador são representados no material analisado. Para tanto, como referencial teórico-metodológico, foram utilizados os estudos sobre a heterogeneidade mostrada, de Authier-Revuz (1998, 2004), e os estudos sobre o paradigma indiciário, de Ginzburg (1991). Os resultados expuseram uma complexidade enunciativa constitutiva da organização do dizer, sob a forma de uma complexa justaposição de enunciações em que o locutor, atribuído à figura de narrador, simula relações dialógicas construídas como enunciadas por diferentes interlocutores nessas relações. Essa complexidade indicia planos de enunciação que marcam uma heterogeneidade de formas de inscrição do outro no (fio do) discurso, que não se enunciam numa transparência do dizer, dada a dialogia que constitui esses planos. Essas diferentes formas sugerem, pois, que se narra por uma justaposição de planos enunciativos.
Desempenho de edifícios altos com emprego da interação solo-estrutura
Authors: Bahia Gabriela de Athayde Duboc , Cunha Renato Pinto da , Mota Neusa Maria Bezerra
Published: January 2021

Este trabalho apresentou como objetivo verificar a influência da interação solo-estrutura (ISE) em um edifício alto por meio de um processo iterativo entre os programas CAD/TQS e GARP realizado no trabalho de Bahia (2015). Para isso, escolheu-se uma edificação residencial, localizada em Águas Claras/DF, com dados de controle de recalques e provas de carga. Iniciou-se a modelagem da estrutura, com a utilização do programa CAD/TQS, considerando os apoios indeslocáveis. Com os resultados dos esforços obtidos foram calculados os recalques das fundações por meio do software GARP. Em seguida, procedeu-se a retroanálise dos esforços da estrutura, flexibilizando os apoios com os dados de recalque obtidos pelo GARP. Esta iteração foi realizada até que a convergência dos resultados de carregamento e recalque fosse alcançada. Os efeitos do ISE foram verificados para os primeiros andares do edifício. As maiores variações foram do esforço normal (Fz) de 0,7 kN no P216 ao final do 2° pavimento; do momento em x (Mx) de -118,3 kN.m no P216 ao final do 1° pavimento; do momento em y (My) de -0,7 kN.m no P221 ao final do 1° pavimento. No caso dos recalques, os resultados se aproximaram mais aos do monitoramento de recalques após a ISE, porém a média da variação relativa ainda foi alta, atingindo -38,9%. Os resultados se mostraram satisfatórios, visto que pesquisas recentes têm apresentado diminuição de recalques, considerando a ISE, e aumento dos esforços.
First-line treatment of advanced ovarian cancer: an expert update
Authors:   Department of Oncology, University Hospital Split and School of Medicine Split, Croatia, Petrić-Miše Branka
Published: January 2021

Ovarian cancer is the fifth most common cause of death among malignant diseases in women in Europe. The standard treatment is cytoreductive surgery, followed by platinum-taxane based chemotherapy. In patients with advanced disease, a valid option is a neoadjuvant chemotherapy followed by interval debulking surgery. Despite the progress in primary treatment, almost 70% of the patients relapse. There is a significant need for better first-line treatment to avoid or delay relapse and improve ovarian cancer outcomes. The most significant change involves the changes in the treatment schedule and new drugs in first-line chemotherapy. Bevacizumab is approved in first-line treatment combined with carboplatin and paclitaxel as it improves progression-free survival (PFS) in patients with a higher risk of recurrence. After achieving the response to first-line chemotherapy, maintenance therapy with poly-adenosine-diphosphate-ribose-polymerase (PARP) inhibitors prolongs PFS in patients with homologous recombination deficiency (HRD). Patients with BRCA mutations obtain the most significant benefit.
The importance of physical activity in colorectal cancer prevention
Authors:   School of Medicine, University of Zagreb and Croatian Institute of Public Health, School of Public Health Andrija Štampar, Zagreb, Croatia, Antoljak Nataša
Published: January 2021

Colorectal cancer is the second most common malignant neoplasm and the second cause of death from malignancies in both sexes. In 2017, 3689 people were diagnosed in the Republic of Croatia. Two thousand ninety-five people died of colorectal cancer in 2019. Colorectal cancer is preventable, and it appears that smoking and obesity are factors that affect its onset. Physical inactivity is closely related to obesity, and the question is whether it can be an independent predictor of colon cancer. We searched the literature on Pubmed for the past five years, including systematic reviews and meta-analyses on the association between physical activity and colon cancer incidence. Studies are methodologically diverse and involve different approaches. In most observational studies, greater physical activity is associated with a lower incidence of colon cancer, while in the interventional studies, results were more diverse. In general, smoking tobacco products has a much greater effect on colon cancer development, but physical activity is linked to the onset of the disease and should be one of the prevention measures.
FOR ELABORATION OF THE CONCEPT OF SCIENTIFIC LIBRARIES OF THE SIBERIAN BRANCH OF THE RUSSIAN ACADEMY OF SCIENCES HUMAN RESOURCES’ PROGRESS
Authors: Makeeva О. V. , Dergileva Т. V. , Artemyeva E. B.
Published: January 2021

Changes taking place in the society have a significant impact on libraries functioning. The areas of activities of scientific libraries that provide information support to scientists and specialists are expanding and modifying, which requires upgrading professional competencies of employees, causing constant professional development of their human resources and intensifying methodological support of activities. The State Public Scientific Technological Library of the Siberian Branch of the Russian Academy of Sciences (SPSTL SB RAS), being the scientific and methodological center of the Siberian Branch of the Russian Academy of Sciences (SB RAS) libraries, initiated work on elaboration of a concept for developing human resources of libraries included in the library system (59 libraries of local library subsystems of Novosibirsk, Buryat, Irkutsk, Kemerovo, Krasnoyarsk, Omsk, Tomsk, Tyumen and Yakutsk scientific centers). The article presents a draft concept proposed for discussion, which provides characteristics of the current situation. The concept defines goals, objectives, principles, directions, mechanisms, organizational and functional structure, targets for the development of human resources potential of SB RAS libraries, as well as vectors of development of SPSTL SB RAS methodological work with the staff of libraries of research institutions. Attention is paid at the development of vertical and horizontal coordination relationships (organizational, functional, methodological and technological), a set of measures is determined that are to ensure the project implementation and the set of goals achievement, lists of librarians’ competencies are proposed. Based the results of the discussion of the document in the library community, elaboration of the strategy for the human resources of SB RAS libraries development is planned, which implementation will increase the efficiency of information support for the scientists and specialists of scientific institutions.
THE INFORMATION BASE OF SIBERIAN AND THE FAR EASTERN LIBRARIES’ LOCAL HISTORY ACTIVITY
Authors: Mandrinina L. A. , Rykova V. V.
Published: January 2021

The article provides a brief overview of library local lore activity with an emphasis on the local lore direction in book studies and bibliography of the Siberian- Far Eastern region; names organizations providing information support for local lore activities of libraries; lists local lore resources on the websites of regional libraries in Siberia and the Far East. Special attention is paid to the resources generated by the State Public Scientific Technological Library of Siberian Branch of the Russian Academy of Sciences, which is the center for information support of local history research in Asian Russia, and obtains unique techniques to create regional databases, as well as highly qualified specialists. It presents a list of databases providing information support of theoretical and practical aspects of local history activity in the regional libraries. Authors give a detailed description of DB “Scientific Sibirika”, which includes regional material on a wide range of local history: history, ethnography, economy, nature and natural resources of certain territories of Siberia and the Far East, Arctic. It is shown that theoretical and methodological research in the field of library local history, individual persons, are presented in the “professional” DB “Librarianship and bibliography in Siberia and the Far East”, which has a special heading “Local lore activities of libraries in Siberia and the Far East”; the bibliologic direction of local lore is implemented in the bibliographic DB “History of books and book business in Siberia and the Far East”. The paper concludes about the importance of library local history in the library activities, and the need to attract information resources of large libraries for more complete implementation of local history research.
Linking Financial Resources Ability and R & D Resources on New Product Performance. The Mediating role of Innovation Orientation and Competitive Position
Authors: Hersugondo Hersugondo , Wahyudi Sugeng , Nuryakin Nuryakin , Laksana Rio Dhani
Published: January 2021

This study aims to test empirical research on the effect of financial resource ability, research and development (R & D) on innovation orientation and competitive position. This study also examines the critical mediating role of innovation orientation and competitive position to achieving new products performance (NPP). This study used a quantitative research approach by comparing data from service industry and manufacture industry in Indonesia included in Indonesian-State-Ownership companies. The analysis unit in this study used middle managers and top managers who responsible for managing divisions within the Indonesian-State-Ownership companies. The number of respondents studied in this study was 287 sample. The purposive sampling technique was used in taking the research sample. This study indicated that financial resources abilities, research and development (R & D) abilities positive effect on innovation orientation and competitive position. This study also testing the importance role of innovation orientation and a competitive position to enhancing new products performance (NPP).
On the Solvability of Z3-Graded Novikov Algebras
Authors: Zhelyabin Viktor , Umirbaev Ualbai
Published: January 2021

Let N = N0+ N1+ N2 be a Z3-graded Novikov algebra. The main goal of the paper is to prove that over a field of characteristic not equal to 3 the algebra N is solvable if N0 is solvable. We also show that a $Z_2$-graded Novikov algebra N=N0+ N2 over a field of characteristic not equal to 2 is solvable if N0 is solvable. This implies that for every n of the form n=2k3l, any Zn-graded Novikov algebra N over a field of characteristic not equal to 2,3 is solvable if N0 is solvable.
Quantum Similarity in our DNA, and in DNA Storage
Authors: M. K. Nassief Andrew
Published: January 2021

The usage of Quantum Similarity through the equation Z = {∀θ ∈ Z → ∃s ∈ S ∧ ∃t ∈ T : θ = (s, t)}, represents a way to analyze the way communication works in our DNA. Being able to create the object set reference for z being (s, t) in our DNA strands, we are able to set logical tags and representations of our DNA in a completely computational form. This will allow us to have a better understanding of the sequences that happen in our DNA. With this approach, we can also utilize mathematical formulas such as the Euler–Mascheroni constant, regression analysis, and computational proofs to answer important questions on Quantum biology, Quantum similarity, and Theoretical Physics.
Derivation of Coulomb's Law Based on a Mechanical Model of Electromagnetic Field and a Spherical Source and Sink Model of Electric Charges
Authors: Wang Xiao-Song
Published: January 2021

We suppose that vacuum is filled with a kind of continuously distributed matter which may be called the $\Omega(1)$ substratum, or the electromagnetic aether. Suppose that the time scale of a macroscopic observer is very large compares to the the Maxwelllian relaxation time of the $\Omega(1)$ substratum. Thus, the macroscopic observer concludes that the $\Omega(1)$ substratum behaves like a Newtonian-fluid. Inspired by H. A. Lorentz, we speculate that electric charges may be extremely small hard spherical sources or spherical sinks with finite radii. Based on the spherical source and spherical sink model of electric charges, we derive Coulomb's law of interactions between static electric charges in vacuum. Further, we derive a reduced form of the Lorentz's force law for static electric charges in vacuum.
Practices with the experiment of the “body fall” with the use of the smartphone stopwatch and with the use of video analysis
Authors: Nunes Emanuelly Torres , Silva Ivanderson Pereira da
Published: January 2021

This study had as main objective to analyze the perceptions of middle school students about the limits and possibilities of using the smartphone's stopwatch and video analysis, through the Tracker software, to explore the phenomenon of falling bodies. For that, a teaching sequence with six stages was proposed and developed in four classes of the 1st grade of High School. This is a qualitative research, of the participant type of research, whose data collection strategies were participant observation and the use of questionnaires. The emerging data were treated in the light of the Discursive Textual Analysis. As main results, it was possible to verify that the students recognized different ways of producing science, meant science as a human product, appropriated different ways of scientific language, recognized the limits and potentialities of the first method, the second and the association between Those.
The influence of art and artistic and creative activities on the quality of information assimilation (complementary semantic approach in education)
Authors: Kashekova Irina E. , Medkova Elena S. , Piryazeva Elena N.
Published: January 2021

Based on the analysis of studies from various areas of scientific knowledge, the article identifies the resources of art and artistic and creative activities having a positive impact on the development of human intellect, creativity, and mental health. The factors and conditions of the beneficial effect of art and artistic and creative activities on the quality of assimilated information are examined. The opportunity for incorporating the languages and methods of art into education is presented by the complementary semantic approach complementary-semantic approach, which, due to the complementarity of the languages of science and art, is aimed at generating different types of thinking (concrete, symbolic, sign, visual, associative, creative) the synthesis of which allows developing the independence of thinking and the skills of social adaptation and collective problem-solving.
Efficacy of herbal medicine in the treatment and immunorehabilitation of preschool children with recurrent acute nasopharyngitis
Authors:   Kemerovo State Medical University, Kemerovo, Russian Federation, Shabaldina E.V. , Akhtyamov D.R. ,   Kemerovo Children's Regional Clinical Hospital, Kemerovo, Russian Federation, Grivtsova S.V. ,   Kemerovo State Medical University, Kemerovo, Russian Federation, Shelkovnikov A.V. ,   Kemerovo Regional Clinical Hospital, Kemerovo, Russian Federation, Apalko S.V. ,   City Hospital No 40, Saint Petersburg, Russian Federation, Shabaldin A.V. ,   Kemerovo State Medical University, Kemerovo, Russian Federation
Published: January 2021

Objective. To assess the efficacy of herbal medicine (HM) in the treatment and immunorehabilitation of children aged 2–6 years with recurrent acute nasopharyngitis. Patients and methods. This study included 327 children aged between 2 and 6 years; 85 of them were healthy and comprised the control group. The remaining children (n = 242) were divided into two groups by simple calendar randomization: the group receiving HM (n = 133) and the group receiving standard treatment (n = 109). All children have undergone the following examinations 45 days following treatment initiation: clinical examination, complete blood count, measurement of total IgE in peripheral blood, rhinocytogram, assessment of nasopharyngeal lavage and cells from the mucous membrane of the posterior wall of the oropharynx. Nasopharyngeal lavage was tested using enzyme-linked immunosorbent assay (ELISA) for the level of cytokines, including interleukins-1β and 4 (IL-1β, IL-4), interferons-α and -γ (IFNa, IFNy), and tumor necrosis factor-α (TNFα).DNA was isolated from the cells of the pharyngeal mucosa and pharyngeal tonsil and for subsequent analysis of the local biotope: bacteria, viruses, and fungi. Results. We found that HM helped to reduce clinical manifestations of acute nasopharyngitis, reduced local inflammation after treatment, and decreased the concentration of opportunistic flora, including Staphylococcus aureus. Conclusion. The inclusion of HM in the treatment regimen for children with recurrent nasopharyngitis increases treatment efficacy and prevents relapses. Key words: nasopharyngitis, immunorehabilitation
Educative Penalty System as a Protection Implementation for Children who Commit Crime
Authors: Eviningrum Sulistya
Published: January 2021

Penalizing children who commit crime is actually intended for their-own sake. This kind of penalty has been created in such a way to suit the children. Therefore, the investigation carried out by the authorities before imposing the penalty should not eliminate the aspect of guidance and protection. The punishment formulations that give deterrent effect to those juvenile criminals should be the best effort through non-formal processes that have an optimal role to develop, such as families, schools, or social monitoring institutions. Namely: a). Informal warning; which involves the police to warn the children that they have done the wrong thing and make them not to do it again. There will not be any criminal minutes for this kind of punishment. b). Redeem mistakes with good deeds/ restitution: the children are asked to redeem their mistakes with good deeds, for example by paying compensation to the victim according to the children's capability. c). Community service: those children are ordered to do serve the community or fulfill certain tasks for several hours.
Implementation of Prudential Principles in the Use of Disinfectants as an Effort to Prevent Covid-19 Pandemic for Legal Protection of Ecosystems
Authors: Handayani Otih
Published: January 2021

The Covid-19 pandemic spreads almost all over the world, including Indonesia. The rapid spread of many fatalities resulted in the government using various means to overcome the pandemic, among others, with preventive efforts through massive disinfectant spraying. This research aims to lysis on applying the principle of prudence in the use of a disinfectant. This research is doctrinal/normative legal research with a statutory approach. Data is collected with literature studies, qualitatively analyzed. The results describe the use of large and inappropriate disinfectants that cause environmental pollution and adverse effects on public health. Environmental law analysis using Law No. 32 of 2009 and the regulations below can protect legal certainty and protect everyone's right to a good and healthy environment to protect the entire ecosystem.
Legal Political Perspective Wage System to Realize Social Justice
Authors: Suhartini Endeh
Published: January 2021

Manpower development is based on Pancasila and the 1945 Constitution of the Republic of Indonesia as regulated in the Manpower Act. In its implementation, labor relations aim to improve the welfare of workers and their families and create social justice in work relations that protect the interests of workers and companies for the sustainability of work relations. This research is empirical, descriptive, and explorative in nature. The results of the study show first.