bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and laboratory manifestations in critically ill patients with COVID-19 and deceased people
Authors: Lysko V.I.  , Moroz А.V. , Holubenko O.S. , Chaika S.M. , Samoilova S.M. , Popova S.S. , Shevelova T.I. , Nasibullin O.Kh. , Chub I.V. , Burakova T.V. , Boklan Yu.O. , Trykhlib V.I. , Danylenko Yu.I. , Kulova O.V. , Samoilenko O.I. , Hrushkevych V.V. , Nevmerzhytsky S.O. , Tsiurak N.R. , Bieliaieva K.P. , Martynchyk О.S. , Yeroshenko A.O. , Lysenko T.I.
Published: August 2021

This article provides a review of the literature on the symptoms, laboratory blood values of critically ill patients who recovered and those who died of the new coronavirus disease COVID-19. Physicians should consider the following when predicting the course of the disease: in the first 3 days after admission, patients who recovered were slightly more likely to have leukocytosis and leukopenia, normal and increased lymphocyte counts; there were more individuals with increased number of band neutrophils, and patients who subsequently died were more likely to have normocytosis, granulocytosis, lymphopenia, thrombocytopenia, and higher erythrocyte sedimentation rate. The evaluation of laboratory indices in dynamics is of great importance for the prognosis: patients who recovered, on day 4–6 had a less pronounced growth of leukocytes and subsequently, on the contrary, their reduction; on day 4–6 of hospital stay, there was a decrease in the number of lymphocytes with subsequent growth; high creatine phosphokinase values at the beginning of hospitalization decreased significantly from day 7–9 to reference values; from the time of hospitalization, there was a decrease in lactate dehydrogenase content; the average prothrombin index tended to decrease, but within normal limits. Patients who died later, already from day 4–6 had an increase in leukocyte count, a decrease in lymphocyte level; thrombocytopenia was registered more often, which persisted with time and decreased significantly, especially after 9 days; in all periods of observation, erythrocyte sedimentation rate was higher (median of 30–40 mm/h); from day 7, there were significant fluctuations in maximum creatine phosphokinase values with their significant increase; at the beginning of hospitalization, these patients had higher lactate dehydrogenase levels compared to the first group and maintained their advantages during all periods of observation with significant fluctuations of maximal values; when comparing these patients by observation periods, there were slight fluctuations in the prothrombin index, which most often registered in about 80 % of patients with a subsequent increase after day 9, but within normal limits; also, at the beginning of hospitalization, there were significant fluctuations in the minimum prothrombin index towards very low rates.
Efficacy of a combination of regional methods of anesthesia with general anesthesia in corneal transplantation
Authors: Mynka N.V. , Kobelyatsky Yu.Yu.
Published: August 2021

Background. Despite the significant development of modern anesthesiology, the pain relief of surgical patients is still unsatisfactory. Inadequate pain management causes psychological discomfort and complications. The combination of general anesthesia with various options for local anesthesia allows one to get closer to solving the problem of pain. The aim of the study was to compare the effect of multicomponent balanced anesthesia (intravenous + inhalation) and multicomponent balanced anesthesia, supplemented by pterygopalatine fossa blockade on the safety and efficacy of anesthesia for corneal transplantation. Materials and methods. The study included 73 patients, divided into two groups. Group С received multicomponent balanced anesthesia, group B — pterygopalatine fossa blockade additionally. The main criteria for evaluating the results of the study were: stability of hemodynamics and gas exchange during surgery, the severity of intraoperative pain syndrome by recording the analgesia nociception index, the severity of postoperative pain syndrome and the incidence of postoperative nausea and vomiting. Results. Both schemes of anesthetic management made it possible to avoid pronounced fluctuations in hemodynamic and gas exchange parameters at all stages of the study. Analyzing the severity of intraoperative pain, we found that in group С, pain relief could be considered insufficient during the first 7 minutes of the most traumatic stage of the operation, while in group B the analgesia nociception index did not decrease below 50. Statistically significant differences were obtained during 8 out of 10 minutes of the stage. Analysis of the pain relief quality in the postoperative period has shown that the level of pain according to the visual analogue scale upon awakening was equal to 0 in both groups, at the next three stages of the study (two and six hours after surgery and on the morning of the next day) the level pain in group C was significantly higher than in group B. Conclusions. The addition of regional blockade to multicomponent general anesthesia allows for adequate control of postoperative pain without compromising the safety profile.
Delirium in neurological practice
Authors: Dubenko O.Ye. , Nikonov V.V.
Published: August 2021

Delirium is an acute, usually reversible, fluctuating impairment of the level of consciousness, attention, and cognitive activity resulted from impaired brain metabolism due to a wide range of various neurological and non-neurological diseases, the effects of drugs and other substances. The main manifestations of delirium are acute changes in consciousness, disturbance of attention, perception, often with the development of hallucinations, emotion, sleep-wake cycle, psychomotor and autonomic activity. Delirium is divided into hypoactive and hyperactive subtypes depending on the severity of psychomotor and emotional disturbances. Patients with acute stroke are also often susceptible to episodes of delirium at the risk factors such as age, pre-existing cognitive impairment, pneumonia, urinary tract infections, and right hemispheric stroke. The pathophysiology of delirium has been less known, but there is evidence of the role of cholinergic deficiency. Delirium is a transient condition, but it needs treatment to prevent the development of complications since it is usually associated with poor functional outcomes, longer hospitalization and higher mortality. The strategy for the treatment of patients with delirium should be directed to early identification of its symptoms, elimination of modifiable risk factors and metabolic causes. In patients with severe symptoms of agitation and hallucinations, short-term prescription of antipsychotics for their relief is possible.
A rare interesting case of fatal air embolism after intravenous contrast during computed tomography
Authors: Hasan Naved Y. , Rugaan Asiah Salem
Published: August 2021

We are reporting a fatal case of air embolism. Although minor cases of air embolism may go unnoticed, this is a case of fatal air embolism after intravenous entry of air, which presented with sudden onset of pulseless electrical activity during a computed tomography scan in the radiology department, requiring cardiopulmonary resuscitation for 15 min. Subsequently, after admission to the intensive care unit, we achieved return of spontaneous circulation. The patient was intubated and ventilated in a shock state. He remained in refractory shock despite of supportive care. Cardiaс arrest was registered again in the catheterization lab and the patient could not be revived after 4 h from the initial cardiac arrest. А computed tomography scan was reported to reveal a significant amount of intra-cardiac air, which was the likely cause patient’s death. The case is a rare condition, which highlights the importance of early diagnosis and delivers a message to the medical staff to have a high index of suspicion in patients who have risk factors, and who develop sudden shock with hypoxemia, in order to treat this potentially life-threatening condition effectively in a timely manner.
Influence of thyroid-stimulating hormone on the recurrence after radiofrequency ablation for atrial fibrillation
Authors: Brynza M.S. , Bogun N.Yu. , Shmidt O.Yu.
Published: August 2021

Atrial fibrillation is one of the most common sustained disorders of cardiac rhythm and is associated with an increased risk of mortality, morbidity due to thromboembolic complications, and heart failure. It is important to highlight that the causative factors are vast. It is well-known that thyroid dysfunction has a proarrhythmic effect and increases the risk of cardiovascular disease. Hyperthyroidism or thyrotoxicosis is recognized to be a baseline risk factor for the development of atrial fibrillation. However, the role of hypothyroidism in atrial arrhythmogenesis is less recognized and not fully understood. At the moment radiofrequency catheter ablation is actively used in the treatment of atrial fibrillation, which in most cases has high efficiency and persistent effect. Despite that, the recurrence of supraventricular tachyarrhythmia can be observed in some patients even after radiofrequency catheter ablation. Patients with a history of hypothyroidism or even high-normal thyroid-stimulating hormone levels are more likely to have a recurrence of supraventricular tachyarrhythmia after radiofrequency catheter ablation. Therefore, thyroid-stimulating hormone levels should be determined in patients who have undergone radiofrequency catheter ablation of atrial fibrillation, especially paroxysmal atrial fibrillation. Consequently, it should be noted that the assessment and correction of modifying risk factors before radiofrequency catheter ablation may provide opportunities for future prevention of recurrence of supraventricular paroxysmal arrhythmias, improve the prognosis and overall quality of life in patients of this group. We have demonstrated the clinical case and emphasized the association of high-normal thyroid-stimulating hormone levels with supraventricular tachyarrhythmia recurrence after radiofrequency catheter ablation for atrial fibrillation.
Blood concentrations of endothelin, interleukins 6 and 10 in men with diabetes mellitus
Authors: Luchytskiy E.V. , Luchytskiy V.E. , Zubkova G.A. , Rybalchenko V.M. , Skladanna I.I.
Published: August 2021

Background. Pathological activation of cytokines is one of the key links in the pathogenesis of diabetes mellitus (DM) and the development of its complications, in particular from the cardiovascular system. According to the vast majority of researchers, the imbalance of pro- and anti-inflammatory cytokines in patients with diabetes mellitus is a significant risk factor for mortality from cardiovascular disease. The purpose of the study was to determine the concentration of markers of a nonspecific inflammatory response (interleukin (IL) 6 and IL-10) in the blood of men with DM and their association with glycated hemoglobin levels and body mass index. Materials and methods. There were examined 46 men with type 2 DM and 28 men with type 1 DM. According to the results of the analysis of variance of the control group, type 2 DM and type 1 DM had significant differences in some indicators. Results. The correlation analysis of the obtained indicators of interleukin concentration showed that in men with type 2 DM under the age of 50 years, the indicators of IL-6 concentration significantly positively correlated with indicators of IL-10 concentration in blood (Spearman’s correlation coefficient 0.562, p<0.031) and negatively with the duration of diabetes mellitus (Spearman’s correlation coefficient –0.508, p<0.031). In the group of patients with type 2 DM aged 50 years and older, there was a positive correlation between the blood concentration of IL-6 with the blood concentration of IL-10 (Spearman’s correlation coefficient 0.509, p<0.031), the blood concentration of IL-10 with glycated hemoglobin levels (Spearman’s correlation coefficient 0.391, p<0.04) and the duration of diabetes mellitus (Spearman’s correlation coefficient 0.551, p<0.005). In the group of patients with type 1 DM, there was a positive correlation of IL-6 in the blood with indicators of the blood concentration of IL-10 (Spearman’s correlation coefficient 0.707, p<0.001) and a positive correlation between the concentration of IL-10 with the duration of DM (Spearman’s correlation coefficient 0.379, p<0.039). Conclusions. Mean levels of IL-6 were significantly elevated in men with type 2 diabetes aged 50 years and older. Mean IL-10 levels were significantly elevated in men with type 2 diabetes regardless of the age of the patients. A significant positive correlation was found between the indicators of IL-6 and IL-10 in the examined patients with type 2 diabetes regardless of age also in patients with type 1 diabetes mellitus.
Evaluation of the achievement of target glycemic levels in children and adolescents with type 1 diabetes mellitus with insulin pump therapy according to a modified training program
Authors: Tashmanova A.B. , Rakhimova G.N. , Berkinbaev S.F.
Published: August 2021

Background. Currently, there is no specialized structured program in the world for group training of patients with type1 diabetes mellitus receiving insulin pump therapy. The purpose of this work was to evaluate the effectiveness of a modified training program in achieving target glycemic levels in children and adolescents with type 1 diabetes mellitus on insulin pump therapy. Material and methods. The training was carried out at the “School of type 1 diabetes mellitus” at the Children’s Clinical Hospital No. 2 in Almaty on an outpatient basis for five days. During the training, a modified program was used, which included all training sections. The survey enrolled 125 children and adolescents with type 1 diabetes mellitus, 68 of them were included in the group of a modified educational program, who studied annually at the “School of type 1 diabetes mellitus”. The group without training (controls) consisted of 57 children and adolescents with type 1 diabetes mellitus, who were trained at the “School of type 1 diabetes mellitus” by the traditional method. All subjects were tested on the basis of a questionnaire, which included 30 key questions on self-control of insulin pump therapy and bread units before and after training. Results. Sixty-eight patients with a modified training program were divided into two subgroups depending on the method of assessing glycemia. The compensation was evaluated by determining the level of glycated hemoglobin (HbA1c). Target therapy levels were better in the modified learning groups than in the control group, which confirms the greater role of motivated parents in the control of type 1 diabetes mellitus, with frequent blood glucose measurements on FreeStyle Libre sensors. Conclusions. The creation of a modified structured training program for patients with type 1 diabetes mellitus, taking into account individual characteristics, as well as cultural and national traditions, is relevant and timely.
Determination of learning requirements of stroke patients with type 2 diabetes in Turkey sample
Authors: Şengül Can Gonca , Uymaz Pelin
Published: August 2021

Background. In the 8th Diabetes Atlas of IDF, it was determined that the diabetes prevalence of Turkey between the ages of 20–79 in 2017 was 12.8%, IGT was 7.4%, and diabetes health expenditures were 5.445 million dollars. This study aimed to determine the learning needs and the factors affecting the need for discharge training in patients with stroke. Materials and methods. This is a descriptive and cross-sectional study with 109 patients consisting the study sample. The study population consisted of stroke patients who were hospitalized in the Neurology Department of a university hospital between April 15 and September 15, 2018. The data were obtained using the Introductory Information Form and and the Turkish version of the “Patient Learning Needs Scale (PLNS)” by the researchers. Analysis of the data can be accessed from the computer. Results. The mean total PLNS score was 200.43±34.77 (204). The drugs sub-dimension had a high importance level in the sub-dimension mean scores, and the community and follow-up sub-dimension had the lowest score with “3.63” in the significance level of sub-dimension mean scores. According socio-demographic characteristics and PLNS, among the groups, the differences were found to be statistically significant in the “Community and Monitoring” and “Skin Care” sub-dimesions. The “place”, sub-dimension of “Treatment and Complications” was found to be statistically significant. The “Health Illness” of the patients and the distribution of PLNS, “Medicines, Daily Life Activities, Community and Monitoring, Treatment and Complications, Skin Care and the difference of Total Scale Score were found to be statistically significant. İn the situation of discharge training given by whom, all sub-dimensions of the scale were found to be statistically significant regarding who the training was received from (p < 0.05). Conclusion. Consequently, the learning needs of patients with stroke were found to be high; thus, individual-specific training should be given in patient discharge education planning.
Pathophysiological and clinical aspects of interaction between coronavirus disease 2019 and thyroid
Authors: Pankiv V.I. , Pashkovska N.V. , Pankiv I.V. , Maslyanko V.A. , Tsaryk I.O.
Published: August 2021

In patients who were not previously diagnosed with any thyroid conditions, the scenario of COVID-19 related anomalies of the thyroid may include either: a process of central thyroid-stimulating hormone disturbances via virus‑related hypophysitis; an atypical type of subacute thyroiditis which is connected to the virus spread or to excessive cytokine production including a destructive process with irreversible damage to the gland or low triiodothyronine syndrome (non-thyroidal illness syndrome) which is not specifically related to the COVID‑19 infection, but which is associated with a very severe illness status. This review aimed to investigate thyroid changes resulted from the COVID-19 infection. Ongoing assessment of the effects of the COVID-19 pandemic will reveal more information on coronavirus-induced thyroid conditions. Routine thyroid assays performed in patients with severe infection/acute phase of COVID-19 are encouraged to detect thyrotoxicosis. After recovery, thyroid function should be assessed to identify potential hypothyroidism. There remain unanswered questions related to the predictive value of interleukin-6 in infected patients, especially in cases of cytokine storm, and the necessity of thyroid hormone replacement in subjects with hypophysitis-related central hypothyroidism.
Diabetes mellitus and acute coronary syndromes
Authors: Serhiyenko V.A. , Serhiyenko A.A.
Published: August 2021

This review article summarizes the existing literature on the current state of the problem of diabetes mellitus and acute coronary syndromes. In particular, the issues are analyzed related to the etiology, epidemiology, main pathophysiological features, classification of acute coronary syndromes, acute coronary syndromes without persistent ST-segment elevation on the electrocardiogram, acute coronary syndromes with ST-segment elevation, non-atherosclerotic causes of acute coronary syndrome, laboratory and instrumental diagnostic tests. Issues were analyzed related to the main approaches to the treatment of acute coronary syndromes, management of patients with diabetes mellitus and acute coronary syndromes, recommendations for secondary prevention. Initial treatment with corticosteroids includes acetylsalicylic acid, bolus heparin and intravenous heparin infusion (in the absence of contraindications). Antiplatelet therapy with ticagrelor or clopidogrel is also recommended. Pain is controlled using morphine/fentanyl and oxygen in case of hypoxia. Nitroglycerin can also be used sublingually or by infusion to relieve pain. Continuous monitoring of myocardial activity for arrhythmia is required. The choice of reperfusion strategy in patients with diabetes mellitus should be based on many factors, including assessment of clinical status (hemodynamic/electrical instability, prolonged ischemia), complications of chronic coronary syndrome, ischemic load, echocardiography, assessment of left ventricular function and any other comorbidities. In addition, various methods for assessing coronary artery disease and predicting mortality due to surgery are needed to make a final decision. Advances in the sensitivity of cardiac biomarkers and the use of risk assessment tools now enable rapid diagnosis within a few hours of symptom onset. Advances in the invasive management and drug therapy have resulted in improved clinical outcomes with resultant decline in mortality associated with acute coronary syndrome.
Prevention of oral diseases: a general somatic approach
Authors: Horachuk V.V. , Dmitrenko I.A.
Published: August 2021

Background. Oral diseases are among the top three causes of the global burden of disease. Numerous scientific studies indicate the relationship between oral diseases and major somatic diseases. However, oral diseases are often viewed as a local problem that is not related to the health of the whole body. The purpose of the study was to substantiate a general somatic approach to the oral health conservancy and recovery based on the analysis of the prevalence of somatic diseases associated with oral diseases, common causal factors of them; to propose strategies for their prevention (on the example of Ivano-Frankivsk region). Materials and me­thods. Data of state and healthcare sector statistics (units), scientific sources (units); bibliosemantic, comparative and statistical analysis; generalizations. Results. It was found that the highest level of prevalence of somatic diseases associated with oral diseases was among the population of working age (due to diseases of the endocrine system, in particular, diabetes mellitus and obesity, cardiovascular diseases, the respiratory system, in particular, asthma, digestive system, rheumatoid arthritis), the population of older age groups and adolescents, as well as among the rural population. Risk behavior of the region's population is a common risk factor for somatic diseases associated with oral diseases due to the high level of alcohol and sugar-containing products consumption, intensive smoking. The preventive programs development for the oral health conservancy and recovery as an important component of overall health has been substantiated. These programs should be complex, intersectoral and interdisciplinary. The program structure consists of population and individual strategies for the prevention of the somatic diseases associated with oral diseases among the population of a given territory. Conclusions. A somatic approach to the prevention of oral diseases will contribute to the formation of policies to integrate the oral health conservancy and recovery into the overall prevention policy in health care.
Problems and perspectives of Ukraine medicine in the fight with the COVID-19
Authors: Authors No
Published: August 2021

No abstract
Clinical significance of anticancer vaccines (literature review)
Authors: Liubota R.V. , Yakovets Zh.P. , Vereshchako R.I. , Anikusko M.F. , Liubota I.I.
Published: August 2021

During the past few decades, the advances in cancer immunotherapy have revived interest in the potential use of vaccines for the malignant tumor treatment. Tumor-associated antigens, which are abnormally expressed by tumor cells, are of decisive importance in the development of anticancer vaccines. Through the stimulation of immunological memory, therapeutic anticancer vaccines can result in long-term remission or healing patients. Therapeutic anticancer vaccines due to the potential safety, specificity and duration of effect can become an alternative to or increase the effectiveness of existing immunotherapies. This article presents data on the tumor antigen structure, characteristics of anticancer vaccines and the results of studies on the clinical efficacy of anticancer vaccines.
Оптимізація протоколів лікування хворих на генералізований пародонтит при кардіоваскулярній патології
Authors: Kopchak O.V. , Biloklytska H.F. , Asharenkova O.V. , Yanishevskyi K.A.
Published: August 2021

Взаємозв’язок між захворюваннями пародонта та соматичною патологією доведений багатьма дослідниками. Аналіз даних, отриманих нами при обстеженні 348 пацієнтів, показав, що в осіб віком до 49 років найбільш часто були діагностовані різні форми гінгівіту (36,3–51,65 %) і генералізований пародонтит (ГП) І–ІІ ступеня (48,35–59,42 %). Проте у віці 50–69 років ГП був домінуючим захворюванням серед обстежених (93,2 % осіб), при цьому 56,03 % пацієнтів мали супутню кардіоваскулярну патологію (КВП). Наші дослідження показали, що, незважаючи на значну поширеність захворювань пародонта при КВП, ці хворі систематично не відвідували лікарів-стоматологів для лікування. Проведені нами дослідження свідчать про значну роль автоімунних процесів у формуванні й прогресуванні хронічних генералізованих захворювань пародонта в пацієнтів із супутніми коморбідними станами, зокрема з кардіоваскулярною патологією. Отримані нами дані переконливо свідчать, що одним із важливих автоантигенів, що визначає форми системної запальної відповіді та прогресування локальної й системної ендотеліальної дисфункції при ГП із КВП, є білки теплового шоку. З огляду на вищезазначене був розроблений новий диференційований підхід до лікування ГП при КВП, оснований на новій концепції патогенезу. Патогенетична терапія ГП при КВП базується на симультантному лікуванні захворювань (із включенням регенеративного методу терапії) з урахуванням тяжкості патологічних процесів, що мають взаємообтяжувальний перебіг. Міждисциплінарна інтеграція лікарів-стоматологів та кардіологів дозволить оптимізувати протоколи лікування з урахуванням наявності й тяжкості соматичної патології та підвищить якість лікування ГП в умовах коморбідності.
Чи ми змінюємось у часі, чи то час змінює нас?
Authors: Oshurko А.P.
Published: August 2021

Безперервний професійний розвиток (БПР) став ключем до прогресу нововведень і впроваджень у практичну діяльність лікаря-стоматолога. Такий нормативно-регулюючий механізм забезпечує всебічний процес саморозвитку та гарантує прогнозовані результати лікування, побудовані на основі доказової медицини. Метою даної роботи є висвітлення розробленої ГО «Асоціація стоматологів України» та апробованої моделі організації БПР на регіональному рівні з національною та міжнародною участю, адаптованої до карантинних вимог та поданої у реальному часі. Такий підхід забезпечує всіх учасників БПР необхідними теоретичними та практичними знаннями для збереження стоматологічного здоров’я людини.
Advertising as Guaranteeing: a Defense of Strict Liability
Authors: Helmreich Jeffrey S.
Published: August 2021

En muchas jurisdicciones, los publicistas son considerados estrictamente responsables de las declaraciones falsas de hechos. Esto puede parecer que se sale del enfoque moral ordinario del discurso, según el cual los individuos describen sus activida-des —la comida que prepararon anoche o la habitación que prepararon para los invita-dos—, sólo tienen que ser sinceros y cuidadosos con lo que dicen; si se esfuerzan en hacer las cosas bien, moralmente están libres de culpa si se equivocan. Esto pudiera dar pie a que se pensara que la responsabilidad objetiva por la publicidad falsa constituye una des-viación de la moralidad ordinaria o un contexto especial que se justifica por un estándar moral distinto a la norma. En este caso, sostengo, más bien, que las deudas comerciales suelen asumir la forma conocida de una acción verbal, en concreto garantías, de las que pretendo demostrar que los interlocutores ya son moralmente responsables de la veraci-dad, independientemente del error. Por esa razón, sostengo que la responsabilidad objeti-va de la publicidad falsa no sólo es justificable, sino que es natural e inevitable.
Derecho y moral (razón práctica): conexiones en tiempos del Estado de derecho constitucional
Authors: Vigo Rodolfo Luis
Published: August 2021

El Estado de derecho constitucional hizo visibles conexiones entre el derecho y la moral racional, y en ese punto, el “movimiento de rehabilitación de la razón práctica” de la década de los setenta, inspirado fuertemente en autores como Kant y Aris-tóteles, aportó un marco teórico funcional a esos fines. Son ejemplos ilustrativos de dicha afirmación las teorías jurídicas de Robert Alexy (dialógica-constructivista) y John Finnis (realista-iusnaturalista), que avalan —con distintos fundamentos— hasta nueve conexio-nes entre el derecho y la moral, las que facilitan una comprensión y operatividad del de-recho al servicio de un objetivamente mejor o más valioso derecho. Si no hay razón capaz de definir lo bueno o lo malo, lo justo o lo injusto se frustra ese propósito y se mantiene la distancia entre aquellas dos disciplinas y realidades inescindiblemente humanas.
Justice, Complexity, and Effective Governance in the Twenty-First Century
Authors: McInerney Thomas F.
Published: August 2021

La democracia constitucional está bajo presión en todo el mundo, gene-rando temor entre los ciudadanos de muchos países. Una fuente clave de consternación es la sensación de que los asuntos que consideramos que estaban resueltos ahora parecen no estarlo. Habiendo codificado e institucionalizado las normas que defienden los derechos humanos fundamentales, las libertades y las normas básicas durante décadas, asumimos que muchos problemas se habían resuelto definitivamente. Después de haber luchado por comprender estos problemas durante los últimos años, he llegado a creer que una fuente clave de nuestra sorpresa y consternación al ver abando-nadas o debilitadas las normas establecidas reside en un malentendido fundamental de la naturaleza y función del derecho. En lugar de establecer significados fijos y eternos, nece-sitamos entender la ley como provisional y en constante cambio. En este artículo, comienzo examinando algunos supuestos fundamentales de la teoría polí-tica, en particular la tradición contractualista. En la segunda parte, examino la reciente crítica basada en la complejidad que cuestiona la posibilidad del diseño legal e institucio-nal. En la tercera parte, considero si las alternativas a la teoría política contractualista y en particular el trabajo de Amartya Sen, podrían ofrecer bases superiores para pensar sobre la justicia política. En la parte final de mis comentarios, considero las implicaciones de estos puntos de vista y ofrezco algunos escenarios sobre cómo el desarrollo y la refor-ma legal e institucional podrían lograrse a través de enfoques más flexibles, participativos y basados en evidencia, a partir de la teoría de la complejidad. En conclusión, sugiero que, a pesar de la promesa de estos enfoques novedosos, es importante reconocer que ninguna estructura institucional puede garantizar la total fidelidad a las normas legales y que si-gue teniendo un papel importante la renovación de los compromisos compartidos de los ciudadanos con los valores fundamentales y la solidaridad social.
Apuntes conceptuales para la identificación de conflictos normativos entre normas
Authors: García Yzaguirre Víctor
Published: August 2021

El artículo tiene por objeto ofrecer criterios de identificación de conflic-tos normativos entre normas jurídicas. Para ello, se realiza una descripción y análisis, desde un enfoque analítico, respecto en qué casos dos normas prescriptivas condicionales son inconsistentes entre sí. Para ello i) delimitaré el tipo de normas relevantes para este estudio; ii) analizaré la necesidad de emplear nociones lógicas para conceptualizar y for-mular criterios de identificación de los casos de conflicto normativo, y iii) daré cuenta de las principales formas de entender la noción de conflicto normativo. Concluiré que es ne-cesario adoptar nociones y principios de la lógica deóntica a efectos de poder diferenciar casos de antinomia y de casos que no lo son.
El consentimiento y la falacia de la necesidad: una réplica a Beyleveld y Brownsword
Authors: Parmigiani Matías
Published: August 2021

En su influyente obra Consent in the Law, Beyleveld y Brownsword nos han prevenido en contra de la “falacia de la necesidad”, que es la pretensión en la que se incurre al suponer que la apelación al consentimiento siempre resulta necesaria para jus-tificar un acto, arreglo o medida que tiene a otra persona de destinataria. La intención del presente trabajo consiste en analizar críticamente esta supuesta falacia, a los fines de precisar si la necesidad de procurar el consentimiento ajeno es mayor o menor que la entrevista por estos autores.
Reflexiones desde el derecho al mejoramiento neural farmacológico (Neuroenhancement)
Authors: Cornejo Plaza María Isabel
Published: August 2021

En este texto se reflexiona acerca de las interfaces existentes entre una práctica novedosa denominada mejoramiento neural farmacológico en relación con las neurociencias, neuroética y neuroderecho. Describe los efectos que esta práctica produce en la cognición de sujetos sanos y, cómo su consumo está siendo problematizado por la literatura especializada, a varios niveles. La literatura destaca los aspectos éticos, de jus-ticia distributiva y los jurídicos en las distintas fuentes del derecho, tanto a nivel funcional como conceptual.
Filosofía del derecho naturalizada: posibilidad y refutación
Authors: Prieto Fetiva Camilo Humberto
Published: August 2021

Uno de los problemas actuales de la teoría del derecho gira en torno a la metodología que debe usar, en tal sentido las discusiones se centran en dos extremos: i) posturas que buscan mantener el método clásico del análisis conceptual, ii) posiciones que persiguen una interdisciplinariedad, lo que trae consigo la incorporación de nuevos méto-dos. Dentro del punto ii) se sitúa la denominada filosofía del derecho naturalizada pro-puesta por Leiter, la cual a su vez se basa en el realismo jurídico norteamericano y en el giro naturalista de Quine e igualmente, tiene como finalidad elevar los estándares de va-lidación empírica de las tesis ius-filosóficas. Así las cosas, el objetivo principal de este trabajo es el de lograr una clarificación concep-tual respecto a la propuesta de una filosofía del derecho naturalizada de Brian Leiter así como analizar las posibles ventajas y problemas que se desencadenan con su aplicación en el campo de la teoría del derecho. En tal sentido, este artículo se dividirá en tres par-tes: i) el giro naturalista en la investigación filosófica y planteamientos genéricos del rea-lismo jurídico norteamericano, 2) el neo realismo jurídico de Brian Leiter y la naturaliza-ción de la teoría jurídica, 3) problemas y críticas de la filosofía del derecho naturaliza-da.
Solar Powered Electric Vehicle Charging Station
Authors: B C Sagar
Published: August 2021

While electric vehicles are generally seen as clean vehicles, they are not completely clean because the production of electricity might generate emissions as well. This paper on a solar powered electric vehicle charging station is a working solution to close the gap in achieving a truly renewable and clean vehicle. The currently scenario of today solar energy ecosystem is that, it is highly unstructured and localized. There are about 50 solar power plants in India but none of them are connect in a manner that there would be a method to perform analytical analysis of the solar energy produced. This paper aims to finding a possible method to connect the solar powered electric vehicle charging station and to perform analytical operations to increase efficiency of Solar Energy.
Smart City Design Principles
Authors: Deora Prachi
Published: August 2021

: A smart city should embrace the concept of sustainable growth, as it is an urgent need, and we cannot hesitate in coping with precious natural resources and plunge into crisis. To make the city run as a smart city, several things should be included in the situation. To make the city run as a smart city, several things should be included in the situation. In the long term, smart city visions that are inclusive, pluralistic, and citizen-centric, focused on developing services and resolving local challenges, would be the most effective and cost-efficient. They are most likely to avoid potential issues by strengthening both physical facilities and amenities, as well as the city’s sense of culture.
Movie Recommendation Model from Data through Online Streaming
Authors: Komurlekar Runali
Published: August 2021

Abstract: With the Pandemic era and easy availability of internet, potential of digital movie and tv series industry is in huge demand. Hence it has led to developing an automatic movie recommendation engine and has become a popular issue. Some of these problems can be solved or at least be minimized if we take the right decisions on what kind of movies to ignore, what movies to consider. This paper examines the recommendations that are obtained with considering the sample movies that have never got an above-average rating, where average rating is defined here as the mid-value between 0 and maximum rating used, for example, 2.5 in 1 to 5 rating scale. The technique used is “collaborative filtering”. Comparison of different pre-training model, it is tried to maximize the effectiveness of semantic understanding and make the recommendation be able to reflect meticulous perception on the relationship between user utilisation and user preference. Keywords: movie recommendation system, user similarity, user similarity, consumption pattern
DOYO Rental Services
Authors: Naik Nora
Published: August 2021

The focus of this project is to design and create a webapp for vehicle rental system in Goa. This enables the owner to rent a vehicle that can be used by a customer in order to discover Goa with the help of famous tourist spots and nearby hotels and restaurants. This webapp Rental System helps the user to search for available cars and bikes and confirm with the owner directly. The user Interface makes the users feel very easy to work on it. The vehicle details can be added to the system or existed vehicle information can be modified too by owner. The transaction details of the vehicle rental system can be fetched by the owner, when its required. Thus, there is no delay in the availability of any vehicle information.
Automatic Speed Reduction to Avoid Accidents
Authors: Murthy V V R
Published: August 2021

Abstract: We analyse the automatic braking system to reduce the speed automatically to avoid the panic action of automobiles. Stop the vehicle when it is in the accidental zone, we applied the velocity calculation according to the weight of the body which can reach to required velocity state to avoid the accident. We are using the electromagnetic braking system to reduce the speed of vehicle it is about meet the accident. In this we achieve a better braking system and also it is relevant to future automobiles. The prototype has been prepared depicting the technology and tested as per the simulated conditions. In future the actual model may be developed depending on its feasibility
Detection of Plant Diseases Using Convolutional Neural Networks
Authors: Kurumaddali Krishna Vamsi
Published: August 2021

Abstract: Introduction of various technologies like Artificial Intelligence, Image Processing, etc. there has been a significant improvement in the growth of various sectors. They have automated a lot of existing tasks that happen to be difficult to be handled manually thereby reducing the load simultaneously providing precision, efficiency and productivity. This research provides various ways to improve the agricultural sector in terms of productivity and also in terms of efficiency. Image processing of crops for analysis, crop disease detection, etc. are some of the various applications of technology in agriculture. This also provides an effective way of monitoring various internal and external factors like soil fertility, water logging capacity, temperature, etc. Providing a much more cost-effective way of increasing agricultural output and improved efficiency, the implementation of modern technologies improves agricultural sector in various ways. Technological improvements provide the farmers security of their crops getting infected by any pests, being impacted by climate changes, etc. These improvements also reduce the time the farmer needs to spend on the farm by utilizing the concept of deep learning and neural networks. There are various other ways in which technology can benefit the agricultural sectors. Keywords: Agriculture, Artificial Intelligence, Deep Learning, Image Processing, Neural Networks.
Monitoring of Health Based On IOT
Authors: Ahuja Sanjograj Singh
Published: August 2021

Abstract: Intelligent and connected medical care is especially significant among various applications empowered by the Internet of Things (IoT). Organized sensors, either worn on the body or installed in our living surroundings, make conceivable the social affair of rich data demonstrative of our physical and psychological wellness. Grabbed consistently, amassed, and viably mined, such data can achieve an extraordinary positive change in the medical care scene. Specifically, the accessibility of information as of recently combined with another age of intelligent approach algorithm can: (a) work with an advancement in the act of medication, from the flow post facto analyse and treat sensitive position, to a proactive structure for a guess of infections at a beginning stage, combined with counteraction, fix, and generally speaking administration of health rather than illness, (b) empower personalization of treatment and the board options focused on especially to the particular conditions and needs of the individual, and (c) assist with reducing the expense of medical services while at the same time further developing results. In this paper, we feature the chances and difficulties for IoT in understanding this idea of things to come of medical care
A família cristã-nova Bernal Nunes de Miranda: entre fronteiras, religiosidades e a Inquisição na Bahia
Authors: Schetini Junior Ademir
Published: August 2021

O texto aborda o discurso da Inquisição portuguesa contra a heresia judaica na Bahia e destaca a atuação da instituição contra a família cristã-nova Bernal Nunes de Miranda. Ao acompanhar o percurso de duas gerações da família, enfatizam-se os aspectos do sangue, da fé e da heterodoxia. O artigo sublinha as migrações de Portugal ao Brasil, aponta as alternativas empregadas para a inserção social e discorre sobre os modos como os indivíduos geriram os estigmas e as barreiras no tempo dos juízes da fé. Analisa, por fim, alguns pormenores da religiosidade estranha ao catolicismo e avalia as possibilidades do criptojudaísmo no século XVIII.
Homens profanos: fluidez identitária entre renegados "portugueses" na Índia (c.1540-1612)
Authors: Nogueira Eduardo Borges de Carvalho
Published: August 2021

O presente artigo oferece análise a respeito de trajetórias de três homens categorizados como apóstatas renegados pelo Santo Ofício de Goa. Súditos da Coroa portuguesa, tais homens, que viveram na Índia a partir de meados dos Quinhentos, aventuraram-se para além dos limites da entidade imperial luso-asiática, o Estado da Índia. Partindo para o Decão, no interior do subcontinente indiano, serviram a sultões, lutaram a favor destes contra portugueses, tornaram-se muçulmanos, assumiram aparência de iogues e retornaram à Cristandade lusitana. Neste contexto, metamorfosearam-se em outros para sobreviverem a duras condições de vida, bem como para escaparem de algozes. De modo a compreender como se deram tais transformações, sobretudo, quanto à identidade dos três renegados, cujas experiências foram analisadas pelo presente artigo mais detidamente a partir de documentação inquisitorial, foram utilizados os conceitos de sagrado e profano de Giorgio Agamben como principais instrumentos teóricos.
Contestação e memória do Tribunal do Santo Ofício: uma perspectiva protestante
Authors: Silva Elizete da
Published: August 2021

Neste artigo, pretendemos analisar as formas de contestação ao Tribunal do Santo Ofício português, empreendidas por setores do Protestantismo europeu, críticos do obscurantismo católico, mas que desenvolveram, também, instrumentos persecutórios na defesa de suas doutrinas. Investigamos, especialmente, no século XVIII, como o Iluminismo e a noção de liberdade de consciência contribuíram para forjar representações e a produção de textos contra as práticas inquisitoriais. Destacamos a trajetória do réu protestante lusitano Francisco Xavier de Oliveyra, escritor de contundentes opúsculos contra o referido tribunal eclesiástico. Abolida a Inquisição Portuguesa em 1821, o nascente Protestantismo Brasileiro, na segunda metade do século XIX, alimentou-se dessa memória na disputa com a Igreja Católica, hegemônica no País.
ANCHORED FALLOPIAN TUBE THROUGH THE DRAIN TUBE: A RARE CASE REPORT
Authors: Shrestha Prezma , Kunwar Asma , Rijal Yasoda , Aryal Susan , Adhikari Yagya , Bhattarai Shiva , Rawal Suniti
Published: August 2021

Stuck drain tube is a rare postoperative complication. We present a case
of 27 years female who underwent right salpingectomy with abdominal
drain on left side. Postoperatively drain couldn’t be removed and
diagnosis of stuck drain was made. Laparotomy revealed Fallopian tube
entering through both eyes of the drain tube.
Using honeynet data and a time series to predict the number of cyber attacks
Authors: Zuzcák Matej , Bujok Petr
Published: August 2021

A large number of cyber attacks are commonly conducted against home computers, mobile devices, as well as servers providing various services. One such prominently attacked service, or a protocol in this case, is the Secure Shell (SSH) used to gain remote access to manage systems. Besides human attackers, botnets are a major source of attacks on SSH servers. Tools such as honeypots allow an effective means of recording and analysing such attacks. However, is it also possible to use them to effectively predict these attacks? The prediction of SSH attacks, specifically the prediction of activity on certain subjects, such as autonomous systems, will be beneficial to system administrators, internet service providers, and CSIRT teams. This article presents multiple methods for using a time series, based on real-world data, to predict these attacks. It focuses on the overall prediction of attacks on the honeynet and the prediction of attacks from specific geographical regions. Multiple approaches are used, such as ARIMA, SARIMA, GARCH, and Bootstrapping. The article presents the viability, precision and usefulness of the individual approaches for various areas of IT security.
The effect of cross-linking procedure on corneal wavefront aberrations in patients with keratoconus
Authors: Resan Mirko , Cvejic Zeljka , Baenninger Philipp , Hafezi Farhad , Massa Horace , Vukosavljevic Miroslav , Pajic Bojan
Published: August 2021

Background/Aim. Corneal cross-linking (CXL) treatment shows the best results in stabilizing the cornea and stopping the progress of the ectatic process. The aim of the study was to assess the impact of CXL on the keratoconus regarding higher-order aberrations (HOAs) and potential improvement of visual function. Methods. In 19 patients, a standard epithelium-off CXL was performed with an energy density of three mW/cm2 for half an hour. The cornea was examined by Pentacam topography before CXL and one and six months after CXL. Best-corrected visual acuity (BCVA), topographic data, and aberrations were collected. Results. A significant reduction in vertical coma was observed from preoperative -1.03 ? 1.89 to -0.74 ? 1.73 (p = 0.004) six months after CXL, and in spherical aberration from preoperative -0.22 ? 1.05 to -0.08 ? 1.13 (p = 0.002) six months after CXL. Root mean square (RMS) HOAs six months after CXL also significantly reduced from 2.31 ? 1.82 to 2.26 ? 1.84 six months after CXL (p = 0.001). BCVA improved from preoperative 0.43 ? 0.15 to 0.71 ? 0.19 six months after surgery (p < 0.001). Conclusion. CXL is a very potent treatment method for keratoconus, which significantly reduces certain corneal wavefront aberrations, especially vertical coma, spherical aberration, and RMS, and leads to a significant improvement in visual acuity.