bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative Radionuclide Imaging Analysis of Enhanced Drug Delivery Induced by Photoimmunotherapy
Authors: Aung Winn , Tsuji Atsushi B. , Sugyo Aya , Fujinaga Masayuki , Zhang Ming-Rong , Higashi Tatsuya
Published: August 2021

Photoimmunotherapy (PIT) is an upcoming potential cancer treatment modality, the effect of which is improved in combination with chemotherapy. PIT causes a super-enhanced permeability and retention (SUPR) effect. Here, we quantitatively evaluated the SUPR effect using radiolabeled drugs of varying molecular weights (18F-5FU, 111In-DTPA, 99mTc-HSA-D, and 111In-IgG) to determine the appropriate drug size. PIT was conducted with an indocyanine green-labeled anti-HER2 antibody and an 808 nm laser irradiation. Mice were subcutaneously inoculated with HER2-positive cells in both hindlimbs. The tumor on one side was treated with PIT, and the contralateral side was not treated. The differences between tumor accumulations were evaluated using positron emission tomography or single-photon emission computed tomography. Imaging studies found increased tumor accumulation of agents after PIT. PIT-treated tumors showed significantly increased uptake of 18F-5FU (p < 0.001) and 99mTc-HSA-D (p < 0.001). A tendency toward increased accumulation of 111In-DTPA and 111In-IgG was observed. These findings suggest that some low- and medium-molecular-weight agents are promising candidates for combined PIT, as are macromolecules; hence, administration after PIT could enhance their efficacy. Our findings encourage further preclinical and clinical studies to develop a combination therapy of PIT with conventional anticancer drugs.
Novel Aptamer-Based Small-Molecule Drug Screening Assay to Identify Potential Sclerostin Inhibitors against Osteoporosis
Authors: Lee Chien-Ching , Hung Chao-Ming , Chen Chung-Hwan , Hsu Yi-Chiang , Huang Yuan-Pin , Huang Tsung-Bin , Lee Mon-Juan
Published: August 2021

A novel aptamer-based competitive drug screening platform for osteoporosis was devised in which fluorescence-labeled, sclerostin-specific aptamers compete with compounds from selected chemical libraries for the binding of immobilized recombinant human sclerostin to achieve high-throughput screening for potential small-molecule sclerostin inhibitors and to facilitate drug repurposing and drug discovery. Of the 96 selected inhibitors and FDA-approved drugs, six were shown to result in a significant decrease in the fluorescence intensity of the aptamer, suggesting a higher affinity toward sclerostin compared with that of the aptamer. The targets of these potential sclerostin inhibitors were correlated to lipid or bone metabolism, and several of the compounds have already been shown to be potential osteogenic activators, indicating that the aptamer-based competitive drug screening assay offered a potentially reliable strategy for the discovery of target-specific new drugs. The six potential sclerostin inhibitors suppressed the level of both intracellular and/or extracellular sclerostin in mouse osteocyte IDG-SW3 and increased alkaline phosphatase activity in IDG-SW3 cells, human bone marrow-derived mesenchymal stem cells and human fetal osteoblasts hFOB1.19. Potential small-molecule drug candidates obtained in this study are expected to provide new therapeutics for osteoporosis as well as insights into the structure–activity relationship of sclerostin inhibitors for rational drug design.
Efficient Generation of Neural Stem Cells from Embryonic Stem Cells Using a Three-Dimensional Differentiation System
Authors: Yoon Sang-Hoon , Bae Mi-Rae , La Hyeonwoo , Song Hyuk , Hong Kwonho , Do Jeong-Tae
Published: August 2021

Mouse embryonic stem cells (ESCs) are useful tools for studying early embryonic development and tissue formation in mammals. Since neural lineage differentiation is a major subject of organogenesis, the development of efficient techniques to induce neural stem cells (NSCs) from pluripotent stem cells must be preceded. However, the currently available NSC differentiation methods are complicated and time consuming. This study aimed to propose an efficient method for the derivation of NSCs from mouse ESCs; early neural lineage commitment was achieved using a three-dimensional (3D) culture system, followed by a two-dimensional (2D) NSC derivation. To select early neural lineage cell types during differentiation, Sox1-GFP transgenic ESCs were used. They were differentiated into early neural lineage, forming spherical aggregates, which were subsequently picked for the establishment of 2D NSCs. The latter showed a morphology similar to that of brain-derived NSCs and expressed NSC markers, Musashi, Nestin, N-cadherin, and Sox2. Moreover, the NSCs could differentiate into three subtypes of neural lineages, neurons, astrocytes, and oligodendrocytes. The results together suggested that ESCs could efficiently differentiate into tripotent NSCs through specification in 3D culture (for approximately 10 days) followed by 2D culture (for seven days).
Using Chemical Ecology to Enhance Weed Biological Control
Authors: Gaffke Alexander M. , Alborn Hans T. , Dudley Tom L. , Bean Dan W.
Published: August 2021

In agricultural systems, chemical ecology and the use of semiochemicals have become critical components of integrated pest management. The categories of semiochemicals that have been used include sex pheromones, aggregation pheromones, and plant volatile compounds used as attractants as well as repellents. In contrast, semiochemicals are rarely utilized for management of insects used in weed biological control. Here, we advocate for the benefit of chemical ecology principles in the implementation of weed biocontrol by describing successful utilization of semiochemicals for release, monitoring and manipulation of weed biocontrol agent populations. The potential for more widespread adoption and successful implementation of semiochemicals justifies multidisciplinary collaborations and increased research on how semiochemicals and chemical ecology can enhance weed biocontrol programs.
Optimising Productivity and Safety of the Open Pit Loading and Haulage System with a Surge Loader
Authors: Aguayo Ignacio Andrés Osses , Nehring Micah , Ullah G. M. Wali
Published: August 2021

The open pit mining load and haul system has been a mainstay of the mining industry for many years. While machines have increased in size and scale and automation has become an important development, there have been few innovations to the actual load and haul process itself in recent times. This research highlights some of the potential productivity and safety benefits that the incorporation of a surge loader may bring to the load and haul system through an analysis of the system, discussion of component characteristics, and mine planning aspects. The incorporation of the surge loader into open pit loading and haulage operations also enables improved safety. This is a result of a reduction in shovel–truck interactions and the reduced likelihood of truck overfilling and uneven loading. This paper details the number of mine worker deaths that a surge loader may have prevented within the Peruvian and Chilean mining industries.
Serenoa Repens (Saw Palmetto) for Lower Urinary Tract Symptoms (LUTS): The Evidence for Efficacy and Safety of Lipidosterolic Extracts. Part II
Authors: Strum Stephen
Published: August 2021

Part I of this 3-part series provided the groundwork for understanding the role of a standardized lipidosterolic extract of Serenoa repens (LSESr) in the treatment of LUTS. It documented that a treatment having a high therapeutic index (i.e., a ratio of benefit to adverse reactions) is a critical need in the demographic context of a rapidly growing elder population. Part I described the clinical symptomatology of LUTS and how it is quantified. A critique of the reports from four authoritative bodies: the European Scientific Cooperative on Phytotherapy (ESCOP), Cochrane 2012, the European Medicines Agency (EMA), and the AUA (American Urological Association) was presented. The foundation above then fine-tuned our search to require (a) consistent evaluability criteria, (b) the quantification of clinical findings, (c) the need to focus on studies employing a standardized LSESr product meeting the fatty acid profile set forth by the European Medicines Agency (EMA) and the US Pharmacopeia and (d) a global assessment of scientific investigations published in all languages and not limited to only English. With the above four constraints, “new” findings about LSESr vs. LUTS are presented. How did the search strategy and selection criteria lead to new understandings about the role of LSESr vs. LUTS? How safe is LSESr in contrast to its counterpart prescription drugs? Of the proposed major mechanisms of action of LSESr (e.g., 5-alpha reductase inhibition and anti-inflammatory activity), what are the key points? After initiating treatment with LSESr, when is clinical improvement seen? How durable is LSESr in ameliorating LUTS? Can LSESr prevent the progression of BPH?
Morphological aspects of decompensated osteoarthritis
Authors: Minasov Timur Bulatovich , Strizhkov Aleksey Evgenievich , Yakupova Ekaterina Rishatovna , Vakhitov-Kovalevich Ruslan Maratovich , Mukhametzyanova Elvina Ilshatovna , Khairutdinov Ruslan Faritovich , Ginoyan Akop Ovikovich
Published: August 2021

Degenerative pathology of the musculoskeletal system is one of the main causes of reduced mobility in patients of an older age group. The purpose of the research: to study the morphological features of the elements of the synovial environment of the knee joint against the background of decompensated osteoarthritis (OA). Signs of adaptation of the articular cartilage of the condyles of the femur in the form of restructuring of the cartilage tissue were revealed. The processes of replacing the subchondral bone with connective tissue followed by sclerosing, which subsequently led to decompensation of the structures of hyaline cartilage, were also revealed. Destructive-dystrophic processes in the menisci of the knee joint were noted. Collateral ligaments in patients with OA show signs of adaptation in the form of an expansion of the endotendineum interlayers between bundles of collagen fibers and an increase in the diameter of blood vessels.
Endogenous intoxication syndrome in pyelonephritis and methods of its therapy with the use of nutrient support
Authors: Letifov G. M.
Published: August 2021

Endogenous intoxication syndrome in pyelonephritis and methods of its therapy using nutritional support G.M. Letifov FSBEI HE «Rostov State Medical University Ministry of Health of Russia Rostov-on-Don Summary The aim of the study was to scientifically substantiate and determine the prospects for the use of nutritional support in the form of the use of dietary supplements containing a complex of natural dietary fibers, inulin (from artichoke), effective probiotics-short-chain fructooligosaccharides, maltodextrin 1.5 teaspoon 2 times a day. The course of treatment is 3 weeks. The appointment of a prebiotic complex, prevention of dysbiosis and restoration of the intestinal barrier function significantly reduced the risk of re-entry of opportunistic intestinal flora into the urinary system, thereby reducing the need for antibacterial prophylaxis of recurrent pyelonephritis.
Features of mental health and emotional burnout syndrome among teachers-defectologists of specialized educational institutions of school and primary vocational education
Authors: Suvorov Vadim Germanovich , Belova Tatyana Olegovna , Suvorova Kira Osipovna
Published: August 2021

The article presents the results of a study of the psychological characteristics of emotional «burnout» in 55 teachers — oligophrenopedagogues. It was found that this category of subjects compared with teachers of mass educational institutions has a more frequent and early formation of the syndrome of emotional «burnout» with a predominance of phases of stress and exhaustion, leading to pronounced psychological disorders.
Features of accounting for property taxes by institutions
Authors: Gerasimova Larisa Nikolaevna
Published: August 2021

The article analyzes the basic rules of taxation for land tax and property tax. It is considered how to report on property taxes. The cases of payment of land tax by institutions, tax bases with and without cadastral value are analyzed. The variants when the land plot occupies the territory of several municipalities, cases when accounting periods are established and not established by local legislation are considered. The calculation of land tax and advance payments on it, as well as their reflection in accounting, is shown. The rules for determining the composition of property that is considered an object of taxation are considered, the calculation of property tax and the rules for reflecting it in accounting are given. Formulas and examples of calculating the average value of taxable property, residual value, advance payments for property tax for the reporting year, including and excluding benefits, and calculating property tax for the year are given.
Digitalization of the interaction of the parties to the employment contract in remote work
Authors: Lebedev V.A. , Lebedeva E.I.
Published: August 2021

From January 1, 2021, amendments to the Labor Code of the Russian Federation regulating remote (remote) work are in force. The new approaches of the legislator to the interaction of the employer and the remote (remote) employee in the conditions of digitalization are considered. The new rules have significantly clarified such key points for the remote format as the procedure for electronic interaction on employment, changes and termination of employment relations. The analysis of legally significant messages as facts of economic life, including the time of their delivery, the risks of participants in the relevant relations, is carried out. A comparative analysis of the use of digital approaches to the regulation of legally significant messages in civil, tax, and procedural legislation is carried out.
Prescribing of long-term antibiotics to adolescents in primary care: a retrospective cohort study
Authors: Lown Mark , McKeown Sam , Stuart Beth , Francis Nick , Santer Miriam , Lewith George , Su Fangzhong , Moore Michael , Little Paul
Published: August 2021

Background

Antibiotic overuse is linked to increased risk of antimicrobial resistance. Long-term antibiotics are commonly used for treating acne and prophylaxis of urinary tract infection. Their contribution to the overall burden of antibiotic use is relatively unknown.

Aim

To describe the volume of commonly prescribed long-term (≥28 days) antibiotic prescriptions in adolescents and young adults, trends over time, and comparisons with acute prescriptions.

Design and setting

A retrospective cohort study using UK electronic primary care records.

Method

Patients born between 1979 and 1996 and with data in the Care and Health Information Analytics database were included. The main outcome measures were antibiotic prescription rates per 1000 person-years and antibiotic prescription days per person-year between the ages of 11 and 21.

Results

In total, 320 722 participants received 710 803 antibiotic prescriptions between the ages of 11 and 21 years from 1998 to 2017. Of these 710 803 prescriptions, 191 443 (26.93%) were for long-term antibiotics (≥28 days and ≤6 months in duration). Long-term antibiotics accounted for more than two-thirds (72.48%) of total antibiotic exposure (days per person-year). Total long-term antibiotic prescribing peaked in 2013 at just under 6 days per person-year and declined to around 4 days in 2017.

Conclusion

Among adolescents and young adults, exposure to long-term antibiotics (primarily lymecycline used for acne) was much greater than for acute antibiotics and is likely to make an important contribution to antimicrobial resistance. Urgent action is needed to reduce unnecessary exposure to long-term antibiotics in this group. Increasing the use of, and adherence to, effective non-antibiotic treatments for acne is key to achieving this.
Population Dynamics of Mud Crab (Scylla serrata) in the Southeastern Coastal Region of Bangladesh
Authors: ZAFAR M. , AMIN S.M. NURUL , RAHMAN M.M.
Published: August 2021

Population parameters of male and female Scylla serrata were estimated using FiSAT software with length-frequency data collected from different areas of Cox’s Bazar, southeastern part of Bangladesh (Chakaria Sundarban, Moheshkhali and Kutubdia channel) to evaluate the growth parameters, mortality rates and exploitation levels. Asymptotic length (L∝) was 105.9 mm and 105 mm, and growth co-efficient (K) was 0.28/yr and 0.36/yr for male and female S. serrata, respectively. The natural mortalities of S. serrata were 0.49/yr and 0.58/yr and fishing mortalities were 0.35/yr and 0.38/yr for male and female accordingly. Recruitment of this species into the fishery takes place throughout the year. The exploitation level for S. serrata was found to be 0.41 for the male and 0.39 for the female. This study showed that the stocks of male and female S. serrata were not under fishing pressure (E< 0.50) in the Southeastern part of Bangladesh.
Growth Response and Heat Shock Protein (Hsp) Expression in Chlorella vulgaris Exposure to Elevated Temperatures
Authors: ZARGAR S. , KRISHNAMURTHI K. , DEVI S. SARVANA , GHOSH T.K. , CHAKRABARTI T.
Published: August 2021

The present paper deals with the impact of various sublethal levels of temperature (26, 31, 33, 36, 39, 42 and 45o C) on growth and heat shock protein (Hsp) expression in freshwater green alga Chlorella vulgaris. Impact of select levels of temperature on growth rate (based on optical density), population count, chlorophyll-a and biomass, of the alga was evaluated in artificial growth medium for a period of 15 days. To determine the induction of Hsp in the alga, it was exposed to select temperature levels for 3 hrs. and further kept for 6 hrs at culturing conditions at 26o C. Induction of Hsp was confirmed by immuno detection followed by SDSPolyacrylamide gel electrophoresis. The select growth parameters of the alga were reduced drastically at 39, 42 & 45o C. Temperatures below 39o C may be considered as the limit of safe exposure for thermal stress of the alga. The Hsp 70 expression was also observed only at 39o C.
Prevalence of Hepatopancreatic Parvovirus (HPV) in Penaeus monodon Postlarvae from Commercial Shrimp Hatcheries in Tamilnadu, Southeast Coast of India
Authors: UMA A. , KOTEESWARAN A. , KARUNASAGAR INDRANI , KARUNASAGAR IDDYA
Published: August 2021

The prevalence of hepatopancreatic parvovirus (HPV) in Penaeus monodon postlarvae produced from commercial shrimp hatcheries in Tamilnadu, located along the southeast coast of India was studied during the period July 2002 to July 2003. A total of 1020 hatchery tanks rearing postlarvae were screened by microscopic method and polymerase chain reaction (PCR). Microscopic observation of Giemsa stained smear by rapid method or wet mount observation of squash preparation of hepatopancreas from postlarvae samples from the different tanks revealed a prevalence of 7.74% for HPV and 2.75% for dual infection with HPV and monodon baculovirus (MBV). PCR analysis of samples during the period of study showed a prevalence of 9.3% for HPV and 4.5% for dual infection with HPV and MBV.
Differential Expressions of G6PD and Alkaline Phosphatase Isozymes Associated with Ontogeny and Air-breathing Transition in Channa punctate
Authors: AHMAD RIAZ , HASNAIN ABSAR-UL
Published: August 2021

Differential expressions of glucose-6-phosphate dehydrogenase (G6PD) and alkaline phosphatase (ALP) isozymes which are associated with distinct ontogenetic and developmental changes have been monitored using native PAGE. Prehatching organogenesis involving ectoderm and mesoderm coincided with temporal expression of G6PD-6a, G6PD-6b and ALP-2a isozymes. Abrupt expression of ALP-3 isozyme and silencing of G6PD-6b occurred as late as 14-15 day post-hatching at the time of the transition to air-breathing. These results demonstrate that repertory of G6PD and ALP isozymes in C. punctata is modified to meet the bimodal breathing requirements related to glucose and lipid metabolism despite quite advanced stage of development. Some specific features in the distribution of isozymes of the adult tissue have also been documented.
Successful Artificial Breeding of the Mekong Giant Catfish (Pangasianodon gigas, Chevey) Reared in Earthen Ponds by Boostering with Gonadotropin Releasing Hormone Analogue (GnRHa)
Authors: MENG-UMPHAN K. , MANOSROI J. , MANOSROI A.
Published: August 2021

Ten-year-old Mekong giant catfish (MGC) held in captivity were divided in three treatments. Treatment 1 served as the control, treatment 2 was injected once a week with gonadotropin releasing hormone analog (GnRHa) 50 µg•kg-1 and treatment 3 was given 100 µg•kg-1 during the spawning season (May-July, 2002). The highest level of Testosterone (T) in male occurred seven days after injection, but the highest Estradiol (E2) level in female occurred fourteen days after the first injection. The T and E2 levels post-injection were respectively significantly different (P<0.05) compared with the levels before injection. Before the spawning season, T and E2 were 800 ng•ml–1 in the males and 3,179 pg•ml-1 in the females, respectively. During the first and second weeks after injection, the T and E2 levels continued to increase. The male MGC achieved greater and earlier maturation than the females. More sperm density was also observed in treatment 2 and 3 as compared with the control. Better fecundity was also observed in treatment 2. We succeeded in lowering the age at which spawning and fertilization occurred by injecting the fish weekly with GnRHa. This technique will prove useful in captive breeding of MGC to increase the wild population of this endangered species in the Mekong River.
The Potential of Red Kwao Kreua (Butea superba) in Inducing Sex Reversal on Three Strains (Red, Ghana, Chitralada) of Nile Tilapia (Oreochromis niloticus L.) and the Effect of 17-α-Methyltestosterone (MT)
Authors: MENGUMPHAN K. , SAMITASIRI Y. , CARANDANG, JR R.
Published: August 2021

The present study aimed to investigate the potential of red kwao kreua and compare the effect between two MT dosage regimens in terms of inducing sex reversal, survival rate, feed conversion ratio and gain in weight on red, ghana and chitralada strains of Nile tilapia. Red kwao kreua, 100 g kg-1 , 200 g kg-1 and 300 g kg-1 , dried and pounded roots and 40 and 60 mg kg-1 MT were prepared and mixed per one kilogram fishmeal. Results revealed that MT treatments had a comparable effect in terms of male sex ratio, SR, FCR and GW and are statistically significant as compared to the control. Red kwao kreua treatments did not have significant difference with the control and with the MT treatments in some cases. However, a 72.2 + 25.5 % male sex ratio was obtained in treatment 3 of the chitralada strain. As to the effect of the treatments on the three strains it was observed that they generally have comparable effects.
Bioremediation of Nitrite from Brackishwater Using Lignocellulosic Agricultural Waste – Bagasse
Authors: KRISHNANI KISHORE K. , PARIMALA V. , GUPTA B.P. , AZAD I.S. , SHEKHAR M.S.
Published: August 2021

Bagasse is a complex native lignocellulosic agricultural waste left after extraction of juice from sugar cane in sugar mills. Bagasse is commonly used as a captive boiler fuel aside from its minor use as a raw material in the paper industry and in low-value products. There remains an ever present need to convert this material to useful value added products, which is an objective of our continued research. The aim of the present study is to investigate four different materials prepared from bagasse for the removal of nitrite from shrimp farm brackishwater (salinity 27±1 ppt) in laboratory condition. The experimental results showed that nitrite removal is effective using bagasse materials with the dose of 1 and 3 g•L-1. Raw bagasse fiber was found to be most effective followed by dried bagasse powder, which can be attributed to the rapid increase in bacterial counts and periphytic growth combined with ion exchange mechanism. Effect of bagasse materials on other water characteristics such as pH, salinity, alkalinity, dissolved oxygen, ammonia and phosphates has also been studied. The very low cost of lignocellulosic materials is a real advantage that renders it as a suitable alternative for the remediation of nitrite from aquaculture water.
The Effect of Incentivized Electronic Word-of-Mouth (EWOM) on Consumer Purchase Intention
Authors: Tamrin Muhammad Husni , Huda Nurul
Published: August 2021

Objective: Social media has a strong impact as a reference for consumers in getting information about the product. Electronic word-of-mouth (eWOM), which is usually delivered by social media, is still the most secure advertising media. This study provides information about incentivized eWOM on purchase intention and other factors that can affect consumers. Research Design & Methods: The method used in this research is the quantitative method with an associative approach. Descriptive analysis and structural equation modeling were used to measure the influence of these variables. Findings: The results showed that the incentivized eWOM had a significant effect on purchase intention but had no impact on the company’s brand awareness. Meanwhile, the attractiveness of advertising messages has no significant effect in influencing purchase intention but has a significant effect on the company’s brand awareness. Implications & Recommendations: Although this research give contributions to the e-WOM literature, several limitations and future research suggestion deserve mentions. Further research can examine the relative effectiveness of non-monetary incentives. Contribution & Value Added: Researchers have provided input and suggestions to SMEs to optimize incentivized eWOM to increase consumer purchase intention.
The Creation of Intention To Buy through Online Social Ties and Social Media Advertisement
Authors: Roosdhani M. Rifqy , Komaryatin Nurul
Published: August 2021

Objective: The growing number of social media users makes many companies want to get subscribers through their social media activities. There are several choices of strategies that can be done by the company to be able to take the huge market. Research Design & Methods: This study compares the effect of advertising activity on social media and user group development that has a strong tie to intention to buy. Findings: This research found that the social media advertisements has a better impact to intention to buy compared to social ties. Implications & Recommendations: This study was conducted on social media users on land Transportation Company that already has a group in social media, Facebook, and does advertising activities on it. Contribution & Value Added: The results of this study provide theoretical implications in the verification of the previous research results and managerial implications that can help the company in conducting marketing activities through social media.
PENERAPAN MODEL PEMBELAJARAN ADDIE TERHADAP HASIL BELAJAR SISWA PADA MATA PELAJARAN FIQIH
Authors: Qori Amarullah Risal , Fatmah Wahidah Nida
Published: August 2021

Penelitian ini bertujuan untuk mengetahui pengaruh penerapan  model pembelajaran ADDIE  pada mata pelajaran Fikih terhadap hasil belajar siswa kelas VIII Siswa SMPIT Plus Al Ittihad Cianjur  tahun ajaran 2020/2021. Metode yang digunakan pada penelitian ini adalah Quasi Eksperimen. Pada populasi penelitian ini yaitu seluruh siswa kelas VIII yang terdiri dari 8 kelas. sampel pada penelitian ini yaitu kelas VIII A yang berjumlah 30 siswa. Instrumen penelitian berupa soal uraian. Teknik pengumpulan data yang digunakan yaitu tes dan observasi. Teknik analisis data menggunakan SPSS 26.0. Berdasarkan analisis dari hasil hipotesis di atas dapat disimpulkan bahwa nilai sig adalah 0,000. Karena nilai sig < 0,05, maka Ho ditolak, H1 diterima sehingga disimpulkan bahwa terdapat perbedaan hasil belajar fiqih dengan model pembelajaran konvensional  dan dengan menggunakan model pembelajaran ADDIE, dengan kata lain pengunaan model pembelajaran ADDIE sangat efektif dalam meningkatkan hasil belajar fiqih siswa.  Pelaksanaan penerapan model pembelajaran ADDIE pada mata pelajaran Fiqih dengan tema “Kurban” SMPIT Plus Al Ittihad Cianjur dengan menerapkan langkah-langkah pembelajaran ADDIE yaitu, analisis, desain, pengembangan, implementasi dan evaluasi
La “Competencia TIC” desde la mirada de docentes de secundaria: más que habilidades digitales
Authors: Mateus Julio-César , Quiroz María Teresa
Published: August 2021

Este trabajo explora las percepciones de los docentes peruanos sobre las TIC y su rol en la educación. Asimismo, analiza sus opiniones sobre la recientemente creada “Competencia TIC” en el Currículo Nacional peruano. A partir de una metodología cualitativa, realizamos cinco grupos focales entre mayo y octubre de 2019 con docentes en ejercicio de escuelas de la ciudad de Lima, Perú. Concluimos que, a pesar de su necesidad evidente, la alfabetización mediática no es parte de la estructura curricular obligatoria y la “Competencia TIC” que plantea el nuevo Currículo es comprendida más como una habilidad instrumental que con un enfoque sociocultural. Los docentes muestran interés en formarse en medios desde una mirada crítica, aunque requieren de importante orientación que debe traducirse en programas de capacitación y sensibilización que les permita comprender los medios desde una mirada menos centrada en el artefacto y más en los procesos de información y expresión que estos promueven.
Relaciones de poder en el orden del discurso: acceso de las mujeres al poder político
Authors: Jennifer Venegas Paniagua , Stephanie Guillén Rivera
Published: August 2021

La realidad social de las mujeres ha estado marcada por procesos de tensión constante relativos a su derecho de participación política. Este campo de análisis posibilita la discusión sobre la configuración de las relaciones de poder en la sociedad y, por ende, la producción y reproducción de condiciones de vida materiales y subjetivas, que subyacen en el desarrollo de la violencia de género, y que a su vez han determinado el surgimiento de movimientos de reivindicación de derechos. Históricamente la emisión del discurso ha sido restringida mediante diversos procesos de exclusión, desarrollados por Michel Foucault en El orden del discurso (1970). Estos se han evidenciado en el continuo impedimento a las mujeres de acceder a puestos políticos, porque la normativa no lo permitía, o bien, porque sectores hegemónicos no desean que las mujeres ocupen dichos cargos y emitan un discurso político, pues ello implica la cesión de una importante cuota de poder. Ante esto, se implementaron acciones afirmativas como la paridad y la alternancia para propiciar el respeto del derecho de las mujeres a ser electas. Dichas acciones evidenciaron que las respuestas normativas requieren también de cambios culturales que problematicen socialmente la violencia de género, y busquen articuladamente su erradicación
El sistema electoral del Congreso de los Diputados español en las elecciones generales del 10 de noviembre de 2019: representación gráfica y simulaciones de reforma
Authors: Miguel Ángel Sevilla Duro
Published: August 2021

El sistema electoral del Congreso de los Diputados español suele catalogarse como de proporcionalidad corregida. Las últimas elecciones generales, celebradas el 10 de noviembre de 2019, son buena muestra de cómo un sistema tachado tradicionalmente de bipartidista ha respondido ante un contexto pluripartidista sobrevenido. Este artículo pretende representar gráficamente el funcionamiento del sistema en las referidas elecciones prestando atención a sus elementos caracterizadores. Junto a esto ─y a la luz de las principales propuestas de la doctrina─ se realiza una simulación de resultados electorales alterando la circunscripción, el umbral (o barrera) electoral y la fórmula de asignación de escaños. Con todo ello se pretende poner de manifiesto la realidad actual del sistema y su hipotético funcionamiento en atención a las propuestas de reforma.
Democracia interna partidaria: tres resoluciones relevantes y una aproximación a la jurisprudencia electoral
Authors: Wendy González Araya
Published: August 2021

El artículo presenta una revista de la jurisprudencia electoral en material de democracia interna partidaria, deteniéndose en el análisis de tres resoluciones relevantes en la materia, dictadas en el último semestre, relativas a: 1) el cumplimiento partidario del principio de igualdad de participación; 2) el proceso de conformación de un partido político; y 3) la condición de inscripción electoral de los delegados de las asambleas y miembros de los comités ejecutivos.
Aportes de la jurisprudencia electoral a los Objetivos de Desarrollo Sostenible en el período 2015-2020
Authors: Max Alberto Esquivel Faerron
Published: August 2021

El artículo analiza la forma en la que el trabajo desarrollado por el Tribunal Supremo de Elecciones, en su función jurisdiccional, ha colaborado de manera decisiva a que el país cumpla los compromisos adquiridos en la Agenda 2030 de la Organización de la Naciones Unidas y en los Objetivos de Desarrollo Sostenible, lo cual, a su vez, ha contribuido a enfrentar con fortaleza institucional los retos que plantea la actual coyuntura para la democracia costarricense
Influencia del liderazgo en la cultura organizacional
Authors:   , García Aguilar Juanita del Carmen
Published: August 2021

El liderazgo y la cultura organizacional son dos caras de la misma moneda, que no pueden ser estudiadas ni comprendidas por separado. El talento de los líderes está reflejado en su habilidad para trabajar con la cultura, por tanto, la importancia del liderazgo está en la creación, conducción y transformación de la cultura organizacional. En este contexto, la presente investigación tiene como objetivo analizar la influencia del estilo de liderazgo en la cultura organizacional entre las pequeñas y medianas empresas del sector manufacturero de la provincia de Pichincha. Para tal fin, se utilizará una metodología mixta cuantitativa y cualitativa. En lo cuantitativo, se aplicará dos encuestas, a una muestra de 234 empresas, 150 pequeñas y 84 medianas. Para la variable liderazgo el cuestionario MLQ-5X de Bass y Avolio; y, en el caso de la cultura organizacional el cuestionario OCAI de Cameron y Quinn. Lo cualitativo se manifiesta en la adopción de dos grupos focales formados con una muestra de directivos y mandos medios de las pequeñas y medianas empresas. El carácter de la investigación también es mixto, exploratorio, descriptivo y correlacional, de corte transversal. Los datos obtenidos fueron sometidos a una evaluación multivariante. Las técnicas estadísticas utilizadas fueron el Análisis Factorial Confirmatorio (AFC) y el Modelo de Ecuaciones Estructurales (SEM). Se utilizó el software estadístico SPSS versión 24 y el programa AMOS versión 22. Los resultados de la investigación demuestran que el estilo de liderazgo predominante en las PYMES es transformacional, el tipo de cultura organizacional es clan y en lo referente a la relación entre las variables a un nivel de significancia p < 0.05 (0.017) el coeficiente de correlación es -0.159, demostrando que existe una correlación lineal débil pero significativa. Por lo tanto, se concluye que el liderazgo influye, de forma débil, en la cultura organizacional de las pequeñas y medianas empresas manufactureras de la Provincia de Pichincha.
Poner el cuerpo: entre la violencia institucional y la garantía de acceso a la interrupción del embarazo
Authors:   , Vega Lucía de la
Published: August 2021

Hemos pretendido indagar sobre la actuación de les trabajadores de la salud hacia las mujeres y personas con capacidad de gestar que intentan acceder a la interrupción legal del embarazo en el marco del sistema de salud pública de la Región sanitaria N° 11 desde diciembre de 2014 hasta la actualidad, tomando como hito el pedido de disculpas realizado por el Estado Argentino en el caso V.D.A (conocido como L.M.R) (V.D.A vs. Argentina, 2011). Hemos partido de dos hipótesis metodológicas:La primera de ellas es que el sistema de causales e indicaciones de aquel entonces resulta posibilitante de situaciones de violencia institucional por parte de efectores resistenciales/obstructores. La segunda de ellas es que, posicionándonos desde la perspectiva pro persona y la perspectiva de género, la interrupción del embarazo es legítima, no siendo posible admitir restricciones que nos posicionan en una lugar de poder de abuso y discrecionalidad sobre la salud y vida del otro/a.
Assessment of Duration of Adaptation to Conditions of Learning in Cadets
of Military Educational Institutions
Authors: Rakhmanov RS , Bogomolova ЕS , Tarasov AV , Razgulin SA , Shaposhnikova МА , Evdokimov AV
Published: August 2021

Introduction. It is relevant to determine periods of adaptation of local and non-resident students coming from other Russian regions to learning conditions. The objective of our study was to measure duration of cadets’ adaptation to the learning environment as assessed by the incidence of respiratory diseases in view of synergistic effects of health risk factors in the Kaliningrad enclave.
Materials and methods. We conducted a retrospective analysis of the incidence of respiratory diseases in cadets of two military universities (n = 3,381, n = 2,013) by cohorts (local and non-resident students) for five academic years in general and by year.
Results. The proportion of respiratory diseases in university cadets was as high as 70.9 ± 2.0 and 52.1 ± 1.1 % in Universities 1 and 2, respectively. The share of respiratory diseases in the first and fifth-year students was 72.3 and 59.9 % in University 1,and 60.3 and 38.1 % in University 2, respectively. The respiratory disease incidence in non-resident cadets was 1.8 and 1.2 times higher than that in locals: 1,102.6 ± 6.2 versus 617.7 ± 24.5 ‰ and 477.6 ± 14.1 versus 388.2 ± 16.1 ‰ (p = 0.001) in Universities 1 and 2, respectively. We found differences in the rates of acute sinusitis, acute tonsillitis, upper respiratory tract infections and influenza, community-acquired pneumonia, and lower respiratory tract infections between local and non-resident cadets. In the second university, differences in the incidence of acute sinusitis and upper respiratory tract infections were still observed in third-year students while in the first university they were still pronounced in cadets during the fourth year of study. We suppose that they might be attributed to learning conditions, ratios of local to non-resident cadets, differences in living conditions and nutrition between the students.
Conclusion. Duration of the period of adaptation of military university cadets to conditions of learning is influenced by a synergistic effect of adverse environmental factors. Adaptation of non-resident cadets lasts longer due to acclimatization to weather and climate conditions of the enclave. The incidence of respiratory diseases proves the differences in learning conditions between the universities.
Impact of Pandemic COVID-19 on Local Government’s Financial Performance in Indonesia
Authors: Anas M.
Published: August 2021

This research aims to know the impact of covid-19 on the performance of local government in Indonesia. This study uses qualitative approaches — sampling techniques with Stratified Random Sampling, based on the level of worst exposure to COVID-19. The results showed that the COVID-19 outbreak had no significant effect on the financial performance of local governments in Indonesia. The COVID-19 outbreak affects economic activity and people’s lives. The increase in growth was mainly driven by optimism and improvement from the health side. Although economic growth is expected to improve, public activity will not recover due to the limited availability of vaccines. Nevertheless, central and local governments are optimistic about future economic growth after mass and comprehensive vaccination, especially those affected by COVID-19.
Community Perspective on Environmental Pollution in the Citarum River, Karawang-West Java
Authors: Sholeh Muhammad , Pranoto  , Budiastuti Sri , Sutarno
Published: August 2021

The use of polluted Citarum River water can cause various diseases, including diarrhea, skin diseases, respiratory infections, etc. This study examines the causes of Citarum River pollution in terms of how residents care about environmental conservation aspects of the Citarum River. The researchers used qualitative methods using questionnaires to explore public perceptions. This method explores four perceptions covering four main aspects: public perception, community participation, socio-economic community, and sanitation waste aspects. Questionnaire analysis with a bivariate statistical test approach and Cronbach's alpha test has the advantage of being able to clearly describe the updated condition of the Citarum River because the data can be justified. After all, it has a high level of confidence of around 95 percent. The results showed that in terms of public perception of the Citarum River, 68% were good, while in terms of community participation in preserving the Citarum River, 26% of the people also participated well, and 32% participated moderately in the maintenance of the Citarum River. As many as 42% of the community consisting of 27% less participate and 15% do not participate. The results of the questionnaire Socio-economy of the Citarum River community are classified as having a fairly good economic condition 59% and a moderate category 41%. The waste and sanitation questionnaire results showed that public awareness about waste and sanitation was also high. 45% percent of the community has a good awareness of the environment around the Citarum River, and 38% have sufficient awareness.
Managing Online Transportation Policy in Indonesia and Implementing It to Avoid Social Conflict
Authors: Gusti Djasa Pinara , Supriyono Bambang , Wardhono Hendro , Rozikin Mochammad
Published: August 2021

This research aims to analyze online transportation policy and its implementation in Indonesia at the ontological and sociological levels that significantly reduce social conflict. The problem is very interesting to be analyzed by conducting qualitative research based on public policy, abuse of power, and conflict resolution. Data were collected through in-depth interviews, observation, and documentation related to online transportation cases in Indonesia. Data were analyzed by using interactive models, data reduction, data display, data verification, and supported by triangulation. The results were based on the ontological and sociological levels using public policy and power perspectives to improve online transportation policy and practice. The vision and mission of public policy on managing online transportation policy are needed to provide information to stakeholders related to the regulations and sanctions in online transportation. This result provides inputs for better regulation of online transportation in Indonesia for state agencies as public officials and practitioners.
The Importance of Communication Management Improving the Performance of Construction Project Managers in Developing Countries
Authors: Lubis Zulkifli
Published: August 2021

The biggest threat that results in the project not being successful is failure to build a stakeholder project. Based on research on construction projects in developing countries, the lack of communication among workers due to cultural uniformity and the uniqueness of their respective regions can become work constraints that can affect implementation performance and productivity, namely, there is a 69.61% decrease in time performance. The main objective of this research is to analyze the role of communication management in improving the performance of construction project managers in developing countries, particularly the role of construction managers in implementing a construction project. This research uses a qualitative approach and a case study method. Sampling using purposive sampling. Forum Group Discussion to see how the opinions of construction project managers in Indonesia view the importance of communication management in the success of construction projects. The study results explain that the need for Public Relations Infrastructure management plays a role in ensuring various policies and communication to the public. This is a reflection of the effective function of public relations in the implementation of infrastructure development. In carrying out the construction, the construction project manager must pay attention to communication dynamics to support the success of infrastructure development projects. Contractors and other parties involved in infrastructure development must raise awareness of the essence of effective communication in fostering trust in the public concerned with infrastructure development.
The Impact of Internal Social Responsibility Policies on University Teachers
Authors: Rubio-Rodríguez Gustavo Adolfo , Santos Fernando de Almeida
Published: August 2021

The conduct of universities motivated by social practices strengthens their commitment to social responsibility, and professors are seen as significant agents that contribute to optimizing policies in this area. The purpose of this paper is to analyze the impact generated by the internal policies of university social responsibility of a Colombian university, compared to the organizational environment perceived by the professors. The research developed a descriptive, explanatory, and correlational approach. The vote was used to gather information, applied to 54 individuals chosen under stratified sampling by optimal allocation. The results were derived from applying the generalized additive model of location, scale, and shape; these teach that the impact of university social responsibility policies regarding the organizational environment is determined by the professor’s behavior, which depends on incentives to provide free services to low-income groups or communities. This could be interpreted as a lack of commitment that goes beyond what is strictly agreed in the workplace, highlighting the lack of social responsibility policies in favor of the environment surrounding them.
Political Identity and Religious Prejudice in a Post-Conflict Society: A Case Study of Poso, Indonesia
Authors: Kambo Gustiana , Yani Andi Ahmad
Published: August 2021

The article describes an alternative approach to postreligious social conflict analysis. The conflict which occurred in Poso district, Indonesia, is used as an example. The political perspective enables the examination of religious identity politicization in a society. Using the phenomenology method, the authors attempt to explore the meaning of concepts or phenomena based on the consciousness that occurs in some individuals who experiences conflict. The study indicates that the conflict in Poso was due to a change in political flow that was quickly accepted, as was the case with Islamic migrants entering the Poso region. They were initially only a minority, then became more extensive and occupied most of the strategic positions in the bureaucrat. This situation generated the indigenous Christian communities being marginalized that provoke social conflicts arose. Apart from intolerance and negative stigma, religious conflicts are also often triggered by the politicization of religion. This study contributes to strengthening the local context of policymakers in considering minority groups and indigenous peoples in the policy-making process.