bluuebunny/crossref_metadata_2025 huggingface dataset:
Near-Optimal Variance-Based Uncertainty Relations
Authors: Xiao Yunlong , Jing Naihuan , Yu Bing , Fei Shao-Ming , Li-Jost Xianqing
Published: April 2022

Learning physical properties of a quantum system is essential for the developments of quantum technologies. However, Heisenberg’s uncertainty principle constrains the potential knowledge one can simultaneously have about a system in quantum theory. Aside from its fundamental significance, the mathematical characterization of this restriction, known as ‘uncertainty relation’, plays important roles in a wide range of applications, stimulating the formation of tighter uncertainty relations. In this work, we investigate the fundamental limitations of variance-based uncertainty relations, and introduce several ‘near optimal’ bounds for incompatible observables. Our results consist of two morphologically distinct phases: lower bounds that illustrate the uncertainties about measurement outcomes, and the upper bound that indicates the potential knowledge we can gain. Combining them together leads to an uncertainty interval, which captures the essence of uncertainties in quantum theory. Finally, we have detailed how to formulate lower bounds for product-form variance-based uncertainty relations by employing entropic uncertainty relations, and hence built a link between different forms of uncertainty relations.
Targeting Muscle-Resident Single Cells Through in vivo Electro-Enhanced Plasmid Transfer in Healthy and Compromised Skeletal Muscle
Authors: Florio Francesca , Accordini Silvia , Libergoli Michela , Biressi Stefano
Published: April 2022

Skeletal muscle is composed of syncytial muscle fibers, and by various mononucleated cellular types, such as muscle stem cells, immune cells, interstitial and stromal progenitors. These cell populations play a crucial role during muscle regeneration, and alterations of their phenotypic properties have been associated with defective repair and fibrosis in aging and dystrophic muscle. Studies involvingin vivogene modulation are valuable to investigate the mechanisms underlining cell function and dysfunction in complex pathophysiological settings. Electro-enhanced transfer of plasmids using square-wave generating devices represents a cost-effective approach that is widely used to transport DNA to muscle fibers efficiently. Still, it is not clear if this method can also be applied to mononuclear cells present in muscle. We demonstrate here that it is possible to efficiently deliver DNA into different muscle–resident cell populationsin vivo. We evaluated the efficiency of this approach not only in healthy muscle but also in muscles of aging and dystrophic animal models. As an exemplificative application of this method, we used a strategy relying on a reporter gene-based plasmid containing regulatory sequences from thecollagen 1 locus, and we determined collagen expression in various cell types reportedly involved in the production of fibrotic tissue in the dystrophic settings. The results enclosed in this manuscript reveal the suitability in applying electro-enhanced transfer of plasmid DNA to mononucleated muscle-resident cells to get insights into the molecular events governing diseased muscle physiology.
Blocking Intermediate-Conductance Calcium-Activated Potassium Channels in the Macrophages Around Ganglionated Plexi Suppresses Atrial Fibrillation Vulnerability in Canines With Rapid Atrial Pacing
Authors: Ma Yazhe , Fu Yuntao , Wang Youcheng , Yang Mei , Yao Yajun , He Shanqing , Liu Dishiwen , Cao Zhen , Wang Xi , Tang Yanhong , Zhao Qingyan , Huang Congxin
Published: April 2022

Previous studies have indicated that ganglionated plexi (GP) function influences atrial fibrillation (AF) vulnerability, and intermediate-conductance calcium-activated potassium channels (SK4) have a close relationship with cardiomyocyte automaticity and the induction of AF. However, the effects of the SK4 inhibitor on GP function and AF vulnerability are unknown. Eighteen beagles were randomly divided into a control group (n = 6), rapid atrial pacing (RAP) group (n = 6), and triarylmethane-34 (TRAM-34, an SK4 inhibitor) group (n = 6). TRAM-34 (0.3 ml, 15 mmol/L) and saline were locally injected into GPs in the TRAM-34 group dogs and dogs from the other groups, respectively. After that, dogs in the RAP and TRAM-34 groups were subjected to RAP, and the neural activity of anterior right GP (ARGP) and atrial electrophysiology were measured. The levels of inflammatory cytokines and function of macrophages in the ARGP were measured in the three groups. At 10 min after TRAM-34 injection, ARGP activity and atrial electrophysiology did not significantly change. The atrial pacing shortened effective refractory period (ERP) values at all sites and increased the AF vulnerability and ARGP neural activity, while TRAM-34 reversed these changes. The levels of CD68 + cells, induced nitric oxide synthase (iNOS), interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α in the ARGP tissues were higher in the RAP group and TRAM-34 group than they were in the control group. Furthermore, the levels of the CD68 + cells, iNOS, and inflammatory cytokines in the ARGP tissues were higher in the pacing group than those in the TRAM-34 group. Based on these results, administration of TRAM-34 into the atrial GP can suppress GP activity and AF vulnerability during atrial pacing. The effects of TRAM-34 might be related to macrophage polarization and the inflammatory response of GP.
Hybrids Provide More Options for Fine-Tuning Flowering Time Responses of Winter Barley
Authors: Fernández-Calleja Miriam , Ciudad Francisco J. , Casas Ana M. , Igartua Ernesto
Published: April 2022

Crop adaptation requires matching resource availability to plant development. Tight coordination of the plant cycle with prevailing environmental conditions is crucial to maximizing yield. It is expected that winters in temperate areas will become warmer, so the vernalization requirements of current cultivars can be desynchronized with the environment’s vernalizing potential. Therefore, current phenological ideotypes may not be optimum for future climatic conditions. Major genes conferring vernalization sensitivity and phenological responses in barley (Hordeum vulgare L.) are known, but some allelic combinations remain insufficiently evaluated. Furthermore, there is a lack of knowledge about flowering time in a hybrid context. To honor the promise of increased yield potentials, hybrid barley phenology must be studied, and the knowledge deployed in new cultivars. A set of three male and two female barley lines, as well as their six F1 hybrids, were studied in growth chambers, subjected to three vernalization treatments: complete (8 weeks), moderate (4 weeks), and low (2 weeks). Development was recorded up to flowering, and expression of major genes was assayed at key stages. We observed a gradation in responses to vernalization, mostly additive, concentrated in the phase until the initiation of stem elongation, and proportional to the allele constitution and dosage present in VRN-H1. These responses were further modulated by the presence of PPD-H2. The duration of the late reproductive phase presented more dominance toward earliness and was affected by the rich variety of alleles at VRN-H3. Our results provide further opportunities for fine-tuning total and phasal growth duration in hybrid barley, beyond what is currently feasible in inbred cultivars.
Mixture × Genotype Effects in Cereal/Legume Intercropping
Authors: Demie Dereje T. , Döring Thomas F. , Finckh Maria R. , van der Werf Wopke , Enjalbert Jérôme , Seidel Sabine J.
Published: April 2022

Cropping system diversification through annual intercropping provides a pathway for agricultural production with reduced inputs of fertilizer and pesticides. While several studies have shown that intercrop performance depends on the genotypes used, the available evidence has not been synthesized in an overarching analysis. Here, we review the effects of genotypes in cereal/legume intercropping systems, showing how genotype choice affects mixture performance. Furthermore, we discuss the mechanisms underlying the interactions between genotype and cropping system (i.e., sole cropping vs. intercropping). Data from 69 articles fulfilling inclusion criteria were analyzed, out of which 35 articles reported land equivalent ratio (LER), yielding 262 LER data points to be extracted. The mean and median LER were 1.26 and 1.24, respectively. The extracted genotype × cropping system interaction effects on yield were reported in 71% out of 69 publications. Out of this, genotype × cropping system interaction effects were significant in 75%, of the studies, whereas 25% reported non-significant interactions. The remaining studies did not report the effects of genotype × cropping system. Phenological and morphological traits, such as differences in days to maturity, plant height, or growth habit, explained variations in the performance of mixtures with different genotypes. However, the relevant genotype traits were not described sufficiently in most of the studies to allow for a detailed analysis. A tendency toward higher intercropping performance with short cereal genotypes was observed. The results show the importance of genotype selection for better in cereal/legume intercropping. This study highlights the hitherto unrevealed aspects of genotype evaluation for intercropping systems that need to be tackled. Future research on genotype effects in intercropping should consider phenology, root growth, and soil nutrient and water acquisition timing, as well as the effects of weeds and diseases, to improve our understanding of how genotype combination and breeding may help to optimize intercropping systems.
Integrated Analysis of Physiological, mRNA Sequencing, and miRNA Sequencing Data Reveals a Specific Mechanism for the Response to Continuous Cropping Obstacles in Pogostemon cablin Roots
Authors: Yan Wuping , Cao Shijia , Wu Yougen , Ye Zhouchen , Zhang Chan , Yao Guanglong , Yu Jing , Yang Dongmei , Zhang Junfeng
Published: April 2022

Pogostemon cablin (patchouli) is a commercially important medicinal and industrial crop grown worldwide for its medicinal and aromatic properties. Patchoulol and pogostone, derived from the essential oil of patchouli, are considered valuable components in the cosmetic and pharmaceutical industries. Due to its high application value in the clinic and industry, the demand for patchouli is constantly growing. Unfortunately, patchouli cultivation has suffered due to severe continuous cropping obstacles, resulting in a significant decline in yield and quality. Moreover, the physiological and transcriptional changes in patchouli in response to continuous cropping obstacles remain unclear. This has greatly restricted the development of the patchouli industry. To explore the mechanism underlying the rapid response of patchouli roots to continuous cropping stress, integrated analysis of the transcriptome and miRNA profiles of patchouli roots under continuous and noncontinuous cropping conditions in different growth periods was conducted using RNA sequencing (RNA-seq) and miRNA-seq and complemented with physiological data. The physiological and biochemical results showed that continuous cropping significantly inhibited root growth, decreased root activity, and increased the activity of antioxidant enzymes (superoxide dismutase, peroxidase, and catalase) and the levels of osmoregulators (malondialdehyde, soluble protein, soluble sugar, and proline). Subsequently, we found 4,238, 3,494, and 7,290 upregulated and 4,176, 3,202, and 8,599 downregulated differentially expressed genes (DEGs) in the three growth periods of continuously cropped patchouli, many of which were associated with primary carbon and nitrogen metabolism, defense responses, secondary metabolite biosynthesis, and transcription factors. Based on miRNA-seq, 927 known miRNAs and 130 novel miRNAs were identified, among which 67 differentially expressed miRNAs (DEMIs) belonging to 24 miRNA families were induced or repressed by continuous cropping. By combining transcriptome and miRNA profiling, we obtained 47 miRNA-target gene pairs, consisting of 18 DEMIs and 43 DEGs, that likely play important roles in the continuous cropping response of patchouli. The information provided in this study will contribute to clarifying the intricate mechanism underlying the patchouli response to continuous cropping obstacles. In addition, the candidate miRNAs and genes can provide a new strategy for breeding continuous cropping-tolerant patchouli.
Improved Nitrogen Use Efficiency and Greenhouse Gas Emissions in Agricultural Soils as Producers of Biological Nitrification Inhibitors
Authors: Saud Shah , Wang Depeng , Fahad Shah
Published: April 2022

Based on an analysis of the current situation of nitrogen fertiliser application, it is suggested that improving the nitrogen utilisation efficiency of crops is an important means of promoting the sustainable development of agriculture and realises the zero increase in chemical fertiliser application. Nitrate loss and nitrous oxide (N2O) emissions caused by nitrification and denitrification are the main reasons for the low utilisation rate of nitrogen fertilisers. N2O is a greenhouse gas that has caused a sharp increase in global temperature. Biological nitrification inhibition refers to releasing natural compounds that inhibit nitrification from plant roots. The natural compounds released are called biological nitrification inhibitors (BNIs), which specifically inhibit the activity of microorganisms in soil nitrification. Biological nitrification inhibitors can significantly improve rice (Oryza sativa), corn (Zea mays) and other crops by 5–10%, which can increase the nitrogen utilisation rate of corn by 3.1%, and reduce greenhouse gas N2O emissions. Compared with plants that do not produce BNI, the amount of N2O released can be reduced by up to 90%. The BNI released by Brachialactone (Brachiaria humidicola) accounted for 60–90% of the total inhibition of nitrification. In summary, biological nitrification inhibitors that inhibit nitrification, improve nitrogen utilisation and crop yield, and reduce greenhouse gas emissions play an important role. This paper reviews the plants known to release BNIs, reviews the plants known to inhibit soil nitrification but with unknown BNIs and further discusses the important role of bio nitrification inhibition in agricultural systems.
Analysis of College Students’ Entrepreneurship Education and Entrepreneurial Psychological Quality From the Perspective of Ideological and Political Education
Authors: Jin Yuqian
Published: April 2022

The purpose is to meet the needs of social development, encourage college students’ employability, and alleviate social pressure. First, the domestic and international employment situation is discussed along with the derivation of entrepreneurship education. Second, ideological and political education is summarized, and accordingly, its internal advantages and external conditions are explained. Then, the current situation and existing problems of entrepreneurship education in Chinese higher education institutions are analyzed from the perspectives of entrepreneurship ideology, entrepreneurship thinking, and entrepreneurship ability. Consequently, a proposal is put forward to integrate entrepreneurship education into ideological and political education to promote the coordinated development of the multidisciplinary course. Finally, the Questionnaire Survey (QS) is designed on the relationship between college students’ entrepreneurship education and ideological and political education, and the QS is conducted from three aspects: college students’ entrepreneurship views, suggestions, and cognition of the ideological and political education. The QS results show that less than 10% of students are very interested in entrepreneurship education, and most students believe that entrepreneurship education plays a very limited role in their growth. Additionally, classroom teaching accounts for the most in entrepreneurship education, while extracurricular practice accounts for only 15%. In terms of teaching content, 80% of students believe that teachers of professional courses have made outstanding contributions to teaching results, but the number of teachers of professional courses is the least among all teachers. Further, the satisfaction of entrepreneurship education among college students is analyzed through the QS by issuing to three local higher education institutions, finding that the college students’ understanding of entrepreneurship education is incomplete. The advantages of ideological and political education should be fully exerted to improve the recognition of entrepreneurship education, and entrepreneurship education should be integrated into daily teaching content. In this way, entrepreneurship education and ideological and political education can be fused, and entrepreneurship education can promote students’ entrepreneurial ability and entrepreneurial thinking.
Exploration on the Core Elements of Value Co-creation Driven by AI—Measurement of Consumer Cognitive Attitude Based on Q-Methodology
Authors: Zhu Yi , Wang Peng , Duan Wenjie
Published: April 2022

Value co-creation (VCC) goes through the stage of co-production, customer experience, service-dominant logic, and service ecosystem. The integration of science and technology has become a key factor to the process of VCC. The rise and application of artificial intelligence (AI) technology has added a new driving force to VCC and began to affect its original practical logic. Based on the consumer perspective, this study uses Q-methodology to measure consumer cognitive attitude toward the use of AI technology in VCC, aiming to explore the key factors that affect VCC. The study found that content quality, information security, efficiency concern, and degree of manipulation have become the important concerns of consumers for VCC under AI integration. Moreover, their different statements have their specific focus and direction. The study demonstrates and analyzes the importance of the four factors and proposes the combination of human and non-human actors (technology and system) to shape the new model of VCC in the future, which is worth further deepening and exploring for academia and enterprises.
Modeling Noise-Related Timbre Semantic Categories of Orchestral Instrument Sounds With Audio Features, Pitch Register, and Instrument Family
Authors: Reymore Lindsey , Beauvais-Lacasse Emmanuelle , Smith Bennett K. , McAdams Stephen
Published: April 2022

Audio features such as inharmonicity, noisiness, and spectral roll-off have been identified as correlates of “noisy” sounds. However, such features are likely involved in the experience of multiple semantic timbre categories of varied meaning and valence. This paper examines the relationships of stimulus properties and audio features with the semantic timbre categories raspy/grainy/rough, harsh/noisy, and airy/breathy. Participants (n = 153) rated a random subset of 52 stimuli from a set of 156 approximately 2-s orchestral instrument sounds representing varied instrument families (woodwinds, brass, strings, percussion), registers (octaves 2 through 6, where middle C is in octave 4), and both traditional and extended playing techniques (e.g., flutter-tonguing, bowing at the bridge). Stimuli were rated on the three semantic categories of interest, as well as on perceived playing exertion and emotional valence. Correlational analyses demonstrated a strong negative relationship between positive valence and perceived physical exertion. Exploratory linear mixed models revealed significant effects of extended technique and pitch register on valence, the perception of physical exertion, raspy/grainy/rough, and harsh/noisy. Instrument family was significantly related to ratings of airy/breathy. With an updated version of the Timbre Toolbox (R-2021 A), we used 44 summary audio features, extracted from the stimuli using spectral and harmonic representations, as input for various models built to predict mean semantic ratings for each sound on the three semantic categories, on perceived exertion, and on valence. Random Forest models predicting semantic ratings from audio features outperformed Partial Least-Squares Regression models, consistent with previous results suggesting that non-linear methods are advantageous in timbre semantic predictions using audio features. Relative Variable Importance measures from the models among the three semantic categories demonstrate that although these related semantic categories are associated in part with overlapping features, they can be differentiated through individual patterns of audio feature relationships.
“I Think You Are Trustworthy, Need I Say More?” The Factor Structure and Practicalities of Trustworthiness Assessment
Authors: Lee Michael A. , Alarcon Gene M. , Capiola August
Published: April 2022

Two popular models of trustworthiness have garnered support over the years. One has postulated three aspects of trustworthiness as state-based antecedents to trust. Another has been interpreted to comprise two aspects of trustworthiness. Empirical data shows support for both models, and debate remains as to the theoretical and practical reasons researchers may adopt one model over the other. The present research aimed to consider this debate by investigating the factor structure of trustworthiness. Taking items from two scales commonly employed to assess trustworthiness, we leveraged structural equation modeling to explore which theoretical model is supported by the data in an organizational trust context. We considered an array of first-order, second-order, and bifactor models. The best-fitting model was a bifactor model comprising one general trustworthiness factor and ability, benevolence, and integrity grouping factors. This model was determined to be essentially unidimensional, though this is qualified by the finding that the grouping variables accounted for significant variance with for several organizational outcome criteria. These results suggest that respondents typically employ a general factor when responding to items assessing trustworthiness, and researchers may be better served treating the construct as unidimensional or engaging in scale parceling of their models to reflect this response tendency more accurately. However, the substantial variance accounted by the grouping variables in hierarchical regression suggest there may be contexts in which it would be acceptable to consider the theoretical factors of ability, benevolence, and integrity independent of general trustworthiness.
Development and Psychometric Evaluation of Family Caregivers’ Hardiness Scale: A Sequential-Exploratory Mixed-Method Study
Authors: Hosseini Lida , Sharif Nia Hamid , Ashghali Farahani Mansoureh
Published: April 2022

Objective

Caring for patients with Alzheimer’s disease (AD) is a stressful situation and an overwhelming task for family caregivers. Therefore, these caregivers need to have their hardiness empowered to provide proper and appropriate care to these older adults. From the introduction of the concept of hardiness, few studies have been conducted to assess the hardiness of caregivers of patients with AD. Presumably, one reason for this knowledge gap is the lack of a proper scale to evaluate hardiness in this group. This study was conducted to develop a reliable and valid Family Caregivers’ Hardiness Scale (FCHS) to measure this concept accurately among Iranian family caregivers sample.

Methods

This study is a cross-sectional study with a sequential-exploratory mixed-method approach. The concept of family caregivers’ hardiness was clarified using deductive content analysis, and item pools were generated. In the psychometric step, the samples were 435 family caregivers with a mean age of 50.26 (SD ± 13.24), and the data were gathered via an online form questionnaire. In this step, the items of the FCHS were evaluated using face and content validity. Then, the factor structure was determined and confirmed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) followed by convergent and divergent validity, respectively. Finally, scale reliability, including stability, and internal consistency were evaluated.

Results

The finding revealed that FCHS consists of five factors, namely, “Religious Coping” (5 items), “Self-Management” (6 items), “Empathic Communication” (3 items), “Family Affective Commitment” (3 items), and “Purposeful Interaction” (4 items) that explained 58.72% of the total variance. The results of CFA showed a good model fit. Reliability showed acceptable internal consistency and stability.

Conclusion

Based on the results of the psychometric evaluation of the FCHS, turned out that the concept of hardiness in Iranian family caregivers is a multidimensional concept that is most focused on individual-cultural values, emotional family relationships, and social relationships. The designed scale also has acceptable validity and reliability features that can be used in future studies to measure this concept in family caregivers.
Lexical Effects on the Perceived Clarity of Noise-Vocoded Speech in Younger and Older Listeners
Authors: Tamati Terrin N. , Sevich Victoria A. , Clausing Emily M. , Moberly Aaron C.
Published: April 2022

When listening to degraded speech, such as speech delivered by a cochlear implant (CI), listeners make use of top-down linguistic knowledge to facilitate speech recognition. Lexical knowledge supports speech recognition and enhances the perceived clarity of speech. Yet, the extent to which lexical knowledge can be used to effectively compensate for degraded input may depend on the degree of degradation and the listener’s age. The current study investigated lexical effects in the compensation for speech that was degraded via noise-vocoding in younger and older listeners. In an online experiment, younger and older normal-hearing (NH) listeners rated the clarity of noise-vocoded sentences on a scale from 1 (“very unclear”) to 7 (“completely clear”). Lexical information was provided by matching text primes and the lexical content of the target utterance. Half of the sentences were preceded by a matching text prime, while half were preceded by a non-matching prime. Each sentence also consisted of three key words of high or low lexical frequency and neighborhood density. Sentences were processed to simulate CI hearing, using an eight-channel noise vocoder with varying filter slopes. Results showed that lexical information impacted the perceived clarity of noise-vocoded speech. Noise-vocoded speech was perceived as clearer when preceded by a matching prime, and when sentences included key words with high lexical frequency and low neighborhood density. However, the strength of the lexical effects depended on the level of degradation. Matching text primes had a greater impact for speech with poorer spectral resolution, but lexical content had a smaller impact for speech with poorer spectral resolution. Finally, lexical information appeared to benefit both younger and older listeners. Findings demonstrate that lexical knowledge can be employed by younger and older listeners in cognitive compensation during the processing of noise-vocoded speech. However, lexical content may not be as reliable when the signal is highly degraded. Clinical implications are that for adult CI users, lexical knowledge might be used to compensate for the degraded speech signal, regardless of age, but some CI users may be hindered by a relatively poor signal.
A Cohort-Based Case Report: The Impact of Ketamine-Assisted Therapy Embedded in a Community of Practice Framework for Healthcare Providers With PTSD and Depression
Authors: Dames Shannon , Kryskow Pamela , Watler Crosbie
Published: April 2022

Amid an international pandemic and a worsening mental health crisis, ketamine-assisted therapy is emerging as a promising solution for those deemed “treatment resistant.” Post-traumatic stress disorder (PTSD) and depression are on the rise, with accelerating direct (e.g., burden of suffering) and indirect (e.g., disability/role impairment and impact on family) costs. Psychedelic-assisted therapies show significant promise in the treatment of a number of clinically challenging conditions, including depression, anxiety, PTSD, addiction, and end-of-life distress. Ketamine is currently the only safe, effective and legal widely available psychedelic-like medicine. To address the echo pandemic of health care provider distress, a multi-disciplinary team was charged with developing a ketamine-assisted psychotherapy program, delivered in a community of practice (CoP) group model and evaluated in a quality improvement framework. Program evaluation occurred through mixed methods. Quantitative mental health assessments included the PHQ-9 for depression, the PCL-5 for PTSD, GAD-7 for generalized anxiety disorder (GAD), and B-IPF for work/life functionality. Participant narrative feedback was collected to evaluate outcomes and for quality improvement purposes. Mean mental health scores were collected across three cohorts, totaling 94 patients. The mean aggregate scores of participants meeting the mental health assessment cut-off criteria (screening positive) were analyzed to assess clinical significance. Mean aggregate results comparing baseline vs. outcome measures (measured within 1–2 weeks after completion of the 12-week program) were clinically significant, demonstrating significant improvements in depression, post-traumatic stress disorder, generalized anxiety disorder and work/life functionality. In summary, 91% saw improvements in generalized anxiety, 79% saw improvements in depression, 86% of those who screened positive for PTSD now screen negative, and 92% had significant life/work functionality improvements. Qualitative feedback was overwhelmingly positive, with several unsolicited self-reports of transformation. Participant and team feedback enables the program to continue improving with each iteration. Results speak to the effectiveness of ketamine for psychedelic-assisted therapy, supported by a CoP framework. Outcomes are relevant for mental health programming, education and healthcare policy.
Knowledge, Attitudes, and Practices Toward Coronavirus and Associated Anxiety Symptoms Among University Students: A Cross-Sectional Study During the Early Stages of the COVID-19 Pandemic in Bangladesh
Authors: Patwary Muhammad Mainuddin , Disha Asma Safia , Bardhan Mondira , Haque Md. Zahidul , Kabir Md. Pervez , Billah Sharif Mutasim , Hossain Md. Riad , Alam Md. Ashraful , Browning Matthew H. E. M. , Shuvo Faysal Kabir , Piracha Awais , Zhao Bo , Swed Sarya , Shah Jaffer , Shoib Sheikh
Published: April 2022

Background

University students’ knowledge, attitude, and practice (KAP) toward COVID-19 are vital to prevent the spread of the virus, especially in the context of developing countries. Consequently, the present study aimed to determine the KAP levels of university students and associated anxiety during the earlier stage of the pandemic in Bangladesh.

Methods

A cross-sectional, online study with 544 university students was conducted during April 17–May 1, 2020. The questionnaire incorporated several KAP-related test items aligned with the World Health Organization (WHO) guidelines. Anxiety was measured with the 2-item Generalized Anxiety Disorder scale (GAD-2). Multivariable logistic regression analysis was performed to determine the association between KAP levels and anxiety adjusting for sociodemographic variables. Subgroup analyses included rerunning models stratified by gender and quarantine status.

Results

Approximately 50% of students showed high levels of knowledge about COVID-19 guidelines, 59% reported behavioral practices that aligned with COVID-19 guidelines, and 39% had negative attitudes toward COVID-19 guidelines. Attitudes differed by anxiety (χ2 = 23.55, p < 0.001); specifically, negative attitudes were associated with higher anxiety (OR: 2.40, 95% CI = 1.66–3.46, p < 0.001). Associations were significant for male (OR = 2.36; 95% CI = 1.45–3.84, p < 0.001) and female (OR = 2.45; 95% CI = 1.3–4.34; p < 0.001) students. Stratified analyses found non-quarantined students with negative attitudes had three times the chance of experiencing anxiety (OR = 3.14, 95% CI: 1.98–4.98, p < 0.001). Non-quarantined students with low levels of knowledge had half the chance of developing anxiety (OR = 0.49, 95% CI: 0.31–0.78, p < 0.01).

Conclusion

Based on these findings, it is recommended that university authorities continue to prioritize proactive and effective measures to develop higher levels of knowledge, more positive attitudes and better behavioral practices regarding COVID-19 for the mental health of their students.
Testing Emotional Vulnerability to Threat in Adults Using a Virtual Reality Paradigm of Fear Associated With Autonomic Variables
Authors: Brandão Marcus L. , Nobre Manoel Jorge , Estevão Ruth
Published: April 2022

Fear and anxiety are generally assessed as responses of prey to high or low levels of threatening environments, fear-conditioned or unconditioned stimuli, or the intensity and distance between predator and prey. Depending on whether a threat is close to or distant from the individual, the individual exhibits specific behaviors, such as being quiet (freezing in animals) if the threat is distant or fleeing if the threat is close. In a seminal paper in 2007, Dean Mobbs developed an active prevention virtual reality paradigm (VRP) to study a threat’s spatial imminence using finger shocks. In the present study, we used a modified VRP with a distinctive feature, namely a dynamic threat-of-loud noise paradigm. The results showed a significant reduction in the number of times the subjects were captured in the high predator phase (85 dB) vs. control phases, suggesting that the participants were motivated to avoid the high predator. Concomitant with avoidance behavior, a decrease in respiratory rate and an increase in heart rate characterized the defense reaction. These results demonstrate behavioral and autonomic effects of threat intensity in volunteers during a VRP, revealing a profile of defense reaction that reflects the individual emotional susceptibility to the development of anxiety.
Uncovering Barriers to Prenatal Physical Activity and Exercise Among South African Pregnant Women: A Cross-Sectional, Mixed-Method Analysis
Authors: Okafor Uchenna Benedine , Goon Daniel Ter
Published: April 2022

Background

The barriers to prenatal physical activity and exercise have been widely reported in the literature, highlighting context-specific challenges. However, generally, research on prenatal physical activity and exercise among pregnant women in South Africa is rare; and particularly concerning the barriers to their prenatal physical activity practice. This study assessed the barriers to physical activity participation among pregnant women in the Eastern Cape, South Africa.

Methods

This was a sequential explanatory mixed method, predominantly quantitative study involving 1,082 pregnant women. A structured self-administered questionnaire on perceived barriers to physical participation was applied to collect quantitative data; while a subset of 15 pregnant women participated in individual in-depth semi-structured interviews to augment quantitative data. Quantitative and qualitative data were analyzed using descriptive statistics and thematic analysis, respectively.

Results

The results of the quantitative analysis presented major barriers: lack of advice on prenatal physical activity and inadequate or conflicting information about prenatal physical activity; tiredness; work commitments; discomfort; lack of time; low energy; non-accessibility to physical activity; lack of financial resources, and safety concerns for the mother and the baby. Qualitatively, the barriers identified relate to four main themes: individual, lack of information, lack of resources, and environmental barriers.

Conclusion

The major barriers cited by the women were tiredness, lack of time, discomfort, and low energy. They also include lack of support, advice and information about prenatal physical activity. The multiple constraining factors responsible for low or non-prenatal physical activity of pregnant women in this setting highlight the need to tailor interventions to address their individual uniquely perceived barriers.
Effects of Serving as a State Functionary on Self-Rated Health: Empirical Evidence From China
Authors: He Li , Zhang Zixian , Wang Jiangyin , Wang Yuting , Li Tianyang , Yang Tianyi , Liu Tianlan , Wu Yuanyang , Zhang Shuo , Zhang Siqing , Yang Hualei , Wang Kun
Published: April 2022

Purpose

There is a strong link between occupation and self-rated health. Existing research has revealed the effects of occupation on self-rated health outcomes and the corresponding mechanisms. However, there is a lack of research on the effects of state services on self-rated health in China. Therefore, this study focuses on exploring the effects of serving as a state functionary in China on self-rated health to enrich research in related fields.

Method

Based on the data of 14,138 individuals collected from the 2016 China Labour-Force Dynamics Survey, the logit model was used to investigate the effects of serving as a state functionary on self-rated health and the difference in the effects across different populations.

Results

The results show that (1) serving as a state functionary has a significant positive effect on self-rated health; (2) self-rated health of elderly state functionaries is higher than that of younger state functionaries; (3) self-rated health of state functionaries in non-eastern regions is higher than that of state functionaries in eastern regions; and (4) state functionaries with lower education have higher self-rated health than highly-educated state functionaries; (5) Higher self-rated health of state functionaries is achieved primarily through better work time, better work environment and lower relative deprivation.

Conclusion

Serving as a state functionary in China has a significant positive correlation with self-rated health, with differences across populations of state functionaries. This study expands the current literature on the effects of occupation on self-rated health in the context of China.
Impact of Social Participation Types on Depression in the Elderly in China: An Analysis Based on Counterfactual Causal Inference
Authors: Wang Xiaofeng , Guo Jiamin , Liu Huawei , Zhao Tengteng , Li Hu , Wang Tan
Published: April 2022

Objectives

Depression is the leading cause of ill health and disability worldwide, and has become one of the key issues in the public health sector. Social participation is one of the most important measures to support the rapidly aging population and can reduce the risk of depression in the elderly. This study aims to explore the causal relationship between different types of social participation and depression in the elderly, and reduce the level of depression in the elderly by promoting social participation.

Methods

In order to accurately evaluate the causal relationship between participation in different types of social activities and depression in the elderly, this paper uses propensity score matching (PSM) for analysis based on counterfactual framework. The specific matching methods used are: k-nearest neighbor matching method, kernel matching method and radius matching method.

Results

In this study, 31.4% of the elderly have depression, and the proportion of female elderly is significantly higher. Participation in different social activities has different effects on depression in the elderly. Taking into account sample selection bias, participation in friend-making, exercise, and recreational activities can effectively reduce the risk of depression in the elderly. Compared with other social activities, participation in exercise and recreational activities are more helpful to reduce the risk of depression in the elderly. Participating in exercise activities only reduces the risk of depression in 60–69-year-olds, while participating in economic activities increases the risk of depression in the elderly aged 70 and over. Compared with the male elderly, participation in friend-making, exercise, and recreational activities results in the female elderly having stronger resistance to the risk of depression.

Conclusions

Depression was prevalent among the elderly. Through PSM analysis, different types of social participation have different effects on depression in the elderly. In order to maximize the positive effects of different types of social participation on depression in the elderly, it is necessary to provide differentiated social support environment for the elderly. Expanding the research on the relationship between social participation and depression of the elderly will help to formulate more reasonable public health policies and improve the mental health of the elderly.
Assessing the Association Between Internet Addiction Disorder and Health Risk Behaviors Among Adolescents and Young Adults: A Systematic Review and Meta-Analysis
Authors: Wang Jun , Hao Qing-hong , Tu Yang , Peng Wei , Wang Yang , Li Hui , Zhu Tian-min
Published: April 2022

Background

Internet addiction disorder (IAD) is a global issue that has resulted in a slew of physical and emotional consequences. Studies have indicated that health risk behaviors might be the risk factors for IAD. The published literature on the correlation between the two is lacking. Therefore, we conducted a comprehensive analysis to understand better the link between IAD and health risk behaviors among adolescents and young adults.

Methods

We searched ten electronic databases for relevant articles. Data were extracted based on IAD and health risk behaviors ( alcohol, smoking, suicidal, gambling and drug abuse). We calculated odds ratios (ORs), a pooled correlation coefficient (r) and 95% confidence intervals (CIs). A fixed-effect model was applied to summarize the pooled effects. Heterogeneity was examined using I2 statistics and Cochran's Q statistics. All analyses were conducted by using Stata version 15.0.

Results

A total of 16 studies and 61,823 participants were included in this study. Meta-analysis showed that IAD was positively correlated with drinking (r = 0.35; 95% CI 0.32–0.37) and smoking (r = 0.12; 95%CI 0.10–0.15), and was associated with an increased risk of suicidal behavior (OR= 1.95; 95% CI 1.65–2.30), drinking (OR= 1.75; 95% CI 1.65–1.85), and smoking (OR= 1.63; 95% CI 1.54–1.72) among adolescents.

Conclusion

We found significantly increased risks of suicidal behavior, drinking, and smoking in adolescents and young adults with IAD. These findings are important to expand our understanding of IAD and have great guiding significance for preventing health risk behaviors of adolescents and young adults.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021257729, identifier: PROSPERO CRD42021257729.
Understanding Societal Resilience—Cross-Sectional Study in Eight Countries
Authors: Bodas Moran , Peleg Kobi , Stolero Nathan , Adini Bruria
Published: April 2022

Civilian populations that are more prepared for emergencies are more resilient. Ample research has been carried out over the last three decades to identify the factors that contribute to public readiness to emergencies and disasters and enhance societal resilience. However, the analysis did not achieve an in-depth comprehension of the types of contributing factors, namely, contextual vs. target aspects. A cross-sectional study that explored attitudinal factors among civilian populations took place during the months of January–February 2021. Diverse representative samples (N≥ 500 each) of adults from eight countries (Italy, Romania, Spain, France, Sweden, Norway, Israel, and Japan) were engaged. The primary outcomes of this study were individual and societal resilience as well as emergency preparedness. The results suggest that in most countries, levels of trust are relatively high for emergency services and health services, and relatively low for politicians. In the overall sample, the individual preparedness index, which delineates the compliance with general household adjustment recommendation for emergencies, averaged at 4.44 ± 2.05SD (out of 8). Some variability was observed between countries, with some countries (e.g., Spain, Norway, and Italy) reporting higher preparedness rates than others (e.g., Japan). In the overall sample, levels of individual resilience were mediocre. Multivariate analysis showed that the following variables are predictors of societal resilience: trust (β = 0.59), social norms and communality (β = 0.20), individual resilience (β = 0.05), individual preparedness (β = 0.04), risk awareness (β = 0.04), and age (β = 0.03). The results of this study show that there are commonalities and differences between societies across Europe and beyond concerning societal resilience at large, including preparedness, individual resilience, and risk perception. Despite socio-cultural driven differences, this study shows that societies share varied characteristics that may contribute toward a common model for assessing societal resilience and for explaining and predicting resilience and readiness.
The SEED Wellness Model: A Workplace Approach to Address Wellbeing Needs of Healthcare Staff During Crisis and Beyond
Authors: Pai Padmini , Olcoń Katarzyna , Allan Julaine , Knezevic Andrea , Mackay Maria , Keevers Lynne , Fox Mim , Hadley Anne Marie
Published: April 2022

Workplace wellness has gained new meaning and significance in the healthcare workforce in the face of the COVID-19 pandemic. Healthcare workers across the world have carried the burden of responding to the public health crisis by having to work under new pressures and constantly changing environments, take on additional shifts, risk their own health and lives, and cope with the ongoing psychological and emotional strain. The purpose of this paper is to articulate a workplace wellness model applied across hospitals in the Illawarra Shoalhaven Local Health District, a regional area in New South Wales, Australia. The description of the development, components, and lessons learned from the SEED Wellness Model illustrates one possible solution about how to provide better care for the staff thus not only preventing staff burnout and turnover, but also creating lasting organizational benefits. The detailed model description can assist in developing a larger and more rigorous evidence-base to improve staff wellness in healthcare settings, both within Australia and internationally.
Why Is Skin Cancer Risk Elevated at Higher Altitudes?
Authors: Breen Ilana D. , Richmond Jillian M.
Published: April 2022

One of the strongest risk factors for skin cancer is direct exposure to the sun. Sunlight emits ultraviolet (UV) radiation, which can damage the DNA of the cells in our bodies. UV exposure causes mutations in DNA, and these accumulated mutations can lead to skin cancer. Melanin is a pigment present in the skin that gives skin its color. Melanin also helps protect skin against UV radiation and sun damage. In addition to protective effects of the skin, most of the damaging ultraviolet radiation from the sun is filtered out by the Earth’s atmosphere. However, at higher altitudes, there is less atmospheric filtering of UV radiation. Therefore, ultraviolet radiation exposure is increased at high altitudes, which explains the higher risk of skin cancer in regions with high elevation.
Solitary Cecal Ulcer: A Case Report
Authors: Li Chun Qiang , He An-Qi , Liu Gang
Published: April 2022

Background

Solitary cecal ulcer is a rare disease. Its etiology is unknown and there are no pathognomonic symptoms. There are rare reports mimicking carcinoma as seen in this case.

Case Presentation

A 64 year-old woman presented with a history of intermittent right lower abdominal pain for 20 years and worsening for 1 year. Colonoscopy revealed an enormous cecal ulcer. The PET-CT showed increased metabolism of the lesion. She underwent a right hemicolectomy. Histopathological examination revealed chronic non-specific inflammation. A rare diagnosis of the solitary cecal ulcer was ultimately made.

Conclusion

Solitary cecal ulcer is a rare, idiopathic entity. It mimics inflammatory bowel disease, malignancy, infection, etc. The comprehensive images of this case describe the characteristics of the disease.