bluuebunny/crossref_metadata_2025 huggingface dataset:
Pressure Results of Primary Open-Angle Glaucoma Surgery by Trabeculectomy in Kankan, Guinea
Authors:   Faculty of Health Sciences and Techniques, University of Conakry, Republic of Guinea, MD Sovogui , Z Zoumanigui ,   Bartimee Ophthalmological Clinic, Republic of Guinea, MB Doukoure ,   Bartimee Ophthalmological Clinic, Republic of Guinea, F Camara ,   Kankan Regional Hospital, Republic of Guinea, K Vonor ,   University of Kara in Togo, Republic of Guinea
Published: March 2024

Purpose: To assess the pressureal outcomes of primary open-angle trabeculectomy surgery for primary open-angle glaucoma. Materials and Methods: This was a six-month prospective observational study. Patients operated by the trabeculectomy technique and followed during the study period were included. Not included were those who had combined surgery. Recruitment was comprehensive. Our variables were epidemiological, clinical, paraclinical and therapeutic. Epi info version 7.4.0 was used for data analysis. Conclusion: Glaucoma remains a public health problem in Kankan. Trabeculectomy concluded an overall success in lowering postoperative intraocular pressure with almost no complications. Given these results, it would be better to undertake it in 1st intention.
Full Thickness Macular Hole after Laser Assisted in Situ Keratomileusis: A Case Report and Review of the Literature
Authors:   Faculty of Medicine, University of Toronto, Toronto ON, Canada, I Sverdlichenko , S Tayeb ,   Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto ON, Canada, Y You ,   Save Sight Institute, University of Sydney, Sydney, Australia, M Cruz-Pimentel ,   Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto ON, Canada, P Yan ,   Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto ON, Canada
Published: March 2024

Purpose: While myopia is known to be a risk factor for Macular Hole (MH) formation, there have been no reviews evaluating the association between LASIK procedure and MH development. Our case series and literature review examine the clinical characteristics and visual outcomes of patients who developed MH following LASIK. Methods: A retrospective chart review was completed for two patients who developed MH following LASIK. For the literature review, Ovid/MEDLINE was searched for all patients who developed MH following LASIK. Results: Two patients with history of LASIK procedure presented with unilateral MH. Both patients were only mildly myopic and lacked other risk factors for MH. They both underwent pars plana vitrectomy, Internal Limiting Membrane (ILM) peel with ILM flap draped over and tucked into the macular hole, followed by 20% sulfur hexafluoride tamponade. Both cases had MH closure and improvement in final visual acuity. The literature review included 25 cases and 27 eyes with MH following LASIK. Twenty-four cases were female and myopic, and the mean refraction was -8.64 D. The average duration from LASIK to MH development was 15.3 months. Mean preoperative best corrected visual acuity was Snellen 20/235. Seventy-seven percent (21/27) of eyes underwent vitrectomy, with a MH closure rate of 100% and final visual acuity of Snellen 20/89. Conclusion: Myopia is a known risk factor for MH formation. However, LASIK procedure may introduce an additional increased risk of MH formation in myopic eyes. Thus, although rarely reported, patients considering LASIK should be counselled on this potential risk.
INFLUENCE OF MULTIVITAMIN COMPLEX ON ZOOTECHNICAL INDICATORS OF HYBRID YOUNG FATTERN RABBIT
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KULMAKOVA N.I.
Published: March 2024

The problem of increasing the production of highquality, profitable and in-demand livestock products on the market is acute at the present stage of agricultural development. Rabbit breeding today is a promising branch of beef farming, the main product of which is highquality dietary meat. The article presents the results of a study of age dynamics and live weight gain of hybrid young rabbits for fattening when different doses of the multivitamin complex “NutriCel” are included in their diet. From August to October 2023, a scientific and economic experiment was carried out on the territory of the rabbit breeding farm of Russian Rabbit LLC, Kostroma district, Kostroma region. As a result of the scientific experiment, the following data were obtained: the best results were obtained in experimental group No. 2, the animals of which were fed 0.5 ml/animal/day: a significant increase in live weight of young fattening rabbits was 3.06 kg (P≤0.05), which is 0.11 kg (3.59%) more than the control. The absolute increase had an advantage over the analogues of the control and experimental groups No. 1 and No. 3 by 20 g (6.4%; P≤0.01). The average daily gain was higher by 2.64 g (5.77%; P≤0.01) compared with peers in the control group. The relative increase exceeded the control by 0.14% (1.41%). At the same time, the safety of the young animals was 100%. In order to increase live weight gain, we recommend including the multi-vitamin complex “NutriCel” in the diet of rabbits with a dosage of 0.5 ml/bird/day for preventive purposes within 3–5 days from the moment of weaning. It showed a positive effect not only on the zootechnical parameters of young rabbits, but also on immunity in general.
Phenological characteristics of rose cultivars grown in protected soil using hydroponic technology
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Zubik I.N.
Published: March 2024

The results of studies on the phenological characteristics of five cultivars of cut roses (Chiri, Grand Prix, Gratsia, Jumilia, Red Naomi) when grown in low-volume culture in the Moscow region are presented. Jumilia with folded leaves has the greatest potential for budding (7 days), the highest shoot growth activity and early entry into the phase of mass growth of stems and leaves (14 days). Red Naomi in the middle of the row has low bud awakening (14 days), the least shoot growth activity and late entry into the phase of mass regrowth of stems and leaves (21 days). Jumilia, regardless of its location in the greenhouse, and Chiri at the beginning of the row and in the variant with a folded leaf are characterized by faster bud formation (39–41 days). Gratsia and Red Naomi in the middle of the row are characterized by slower bud formation (47–48 days). Jumilia in the folded leaf varieties and at the beginning of the row is distinguished by the earliest entry into the commercial phase (49–50 days). Gratsia and Red Naomi in the middlerow variety (60–62 days) are characterised by long peduncle formation. The longest peduncle at the time of cutting was observed in Gratsia (90,4–95,1 cm) and Jumilia (86,2–90,2 cm). Chiri has the shortest stem (65,4–70,3 cm).
THEORETICAL AND PRACTICAL JUSTIFICATION OF ROOTSTOCK SELECTION IN VEGETATIVE REPRODUCTION OF INTRODUCED SPECIES OF THE GENUS SYRINGA L. (OLEACEAE) IN THE CONDITIONS OF THE ORENBURG REGION
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, NAZAROVA N.M.
Published: March 2024

The proper selection of rootstock and graft combinations in lilac introducers, in order to take full advantage of grafting, requires a thorough understanding of the synergy of cultivar-rootstock combinations, as well as the identification of factors that may influence this process. The article analyzes the results of three grafting experiments using Syringa vulgaris L. and Syringa josikaea J. Jacq. ex Rchb. seedlings and vegetative rootstocks (rooted shoots) of Syringa vulgaris L. as rootstocks. The grafting material was the dormant buds of four highly ornamental cultivars of S. vulgaris L. – ‘Au- cubaefolia’, ‘Sensation’, ‘Marc Micheli’, ‘Congo’ and the late hybrid Syringa × prestoniae МсКelveу ‘Miss Canada’. It was found that the survival rate of cultivars on a particular rootstock may depend on the systematic affiliation of the mother plants of the cultivars. The best survival rate among all studied cultivars in the climatic conditions of the Orenburg region is achieved when using rooted vegetative shoots of S. vulgaris as a rootstock (over 90%), the worst – on the seed rootstock of S. josikea J. Jacq. ex Rchb. (up to 40%). The influence of the ambient temperature and humidity at the time of oculant fusion on the survival rate of grafts using S. vulgaris L. vegetative rootstock has been demonstrated (Wilcoxon T-test, statistical significance level p <<0.05). It is recommended to select the rootstock individually for each cultivar in order to achieve maximum survival rates of lilac cultivars in the climatic and geographical conditions of the Orenburg region and/or regions with similar conditions.
Effectiveness of new herbicides on corn crops in the conditions of the Western Ciscaucasus
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, Filipenko N.N.
Published: March 2024

When studying the effectiveness of using promising herbicides on crops of corn hybrids in the central zone of the Krasnodar Territory, it was found that corn crops are predominantly contaminated with dicotyledonous weeds such as Theophrastus rope, upturned acorn grass, ragwort, white pigweed, self-seeded poppy, and shepherd’s purse. Cereal (monocot) weeds are represented by blue bristle grass, green bristle grass and chicken millet. Perennial weeds include by field bindweed. The most effective herbicide is Adengo in the 1–2 leaf stage, giving a yield increase of 56.1 c/ha. At the same time, corn hybrids in the mid-early group yielded 91.5 c/ha and those in the mid-ripening group 77.1 c/ha. To obtain a corn yield of 100 c/ha, it is necessary to apply the herbicide Adengo (0.5 l/ha) at the stage of 1–2 leaves in the technology of cultivation of its hybrids DKS3969, DKS3 and DKS3789
PROTEIN PRODUCTIVITY OF EARLY-MATURING SOYBEAN VARIETIES IN THE CONDITIONS OF THE KALUGA REGION
Authors:   Timirâzevskaâ selʹskohozâjstvennaâ akademiâ, KHRAMOY V.K.
Published: March 2024

The article presents data on the duration of the growing season, biomass accumulation, seed productivity, protein content in seeds and protein yield with seed yield of four earlymaturing soybean varieties – Magheva, Kasatka, Svetlaya, and Georgiya of the selection of the Institute of Seed Production and Agrotechnology – a branch of the Federal Scientific Agroengineering Center VIM. The study of early-maturing soybean varieties capable of sustainable maturing in the Nonchernozem zone is aimed at solving the problem of protein deficiency in grain crops produced in agricultural enterprises, which is important for the devel- opment of animal husbandry. The research was carried out in 2018–2019 on sod-podzolic, sandy loam soils. The Svetlaya and Kasatka soybean varieties had the shortest growing season – 94 days, the Magheva variety had a 9-day longer growing season and the Georgiya variety had a 14-day longer growing season. The earliest maturing soybean varieties are Svet- laya and Kasatka. The sum of temperatures at the level of 1623°C is sufficient for the formation of seed yield. The soybean varieties Magheva and Georgiya require a sum of temperatures 150–200°C higher. The varieties with a long growing season – Georgiya and Magheva – are characterized by a high level of biomass accumulation and higher seed yield, on average over two years their seed yields were 1.64 and 1.48 t/ha respectively, while those of the varieties Svetlaya and Kasatka were 1.30 and 1.34 t/ha respectively. The soybean variet- ies Magheva (40.7%) and Kasatka (39.8%), while Georgiya (36.1%) had the lowest. Protein yield with the seed yield was more dependent on the seed yield. The correlation coefficient between protein yield and seed yield was 0.91, and between protein yield and seed protein content was 0.19. The varieties with the highest protein yields were Magheva and Georgiya with 602 and 599 kg/ha respectively. The varieties with the lowest protein yield were Kasatka (529 kg/ha) and Svetlaya (500 kg/ha).
Analysis of sterilizer oil losses through variations in pressure and boiling time with dominated fresh fruit bunch overripe fraction
Authors: Renjani Rengga Arnalis , Panjaitan Boy Doli , Fadhillah Nabillah Nissya , Purwoto Harsunu
Published: March 2024

The problem is that not all FFBs processed daily are more than 90% ripe fruit, causing the yield not to reach the target. This study aims to analyze condensate oil losses from non-standard FFB quality (FFB overripe as much as 25-26%) against time and pressure variations in the sterilizer. The observed indicators include oil losses, moisture content, and non-oil solids (NOS). The study was conducted in 2 stages; the first stage was to test the length of boiling time for each peak stew. The second stage is divided into two pressure variations treatments at each stew's peak. The quantitative presented data is analyzed using simple statistics. All data analyzed statistically is presented in graphical form to visualize the data distribution. In overripe FFB conditions, as much as 25-26% shows that the three best times for peak 1 are 10 minutes with a pressure of 1.0 kg/cm2, peak 2 is 15 minutes with a pressure of 1.5 kg/cm2, and peak 3 is 65 minutes with pressure 3.1 kg/cm2. he best boiling based on the right boiling time to achieve the lowest oil losses is 90–100 minutes in one boiling cycle. If a boiling cycle of 90-100 minutes is carried out, the oil losses achieved are 0.78-0.98%. The longer the boiling process is under FFB overripe, the more oil comes out of the mesocarp and finally comes out mixed with condensate water.
Performa Tungku Hibrid Energi Surya dan Gas untuk Alat Pengering Kabinet dengan Sistem Cerdas
Authors: Amalia Anugerah Fitri , Waris Abdul , Mursalim Mursalim
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengevaluasi kinerja alat pengering kabinet yang menggunakan hibrid energi surya dan LPG. Energi terbarukan sangat penting untuk pengeringan pertanian. Mesin pengering sistem hibrid ini menggunakan teknologi fuzzy logic dan expert system untuk mengoptimalkan jumlah energi yang digunakan. Metode pengujian meliputi: uji kolektor surya, katup udara dan gas, serta pengeringan dan konsumsi energi dengan menggunakan 10 kg sagu segar. Hasilnya menunjukkan bahwa hibrid dan non-hibrid (gas saja) memenuhi persyaratan suhu dan kadar air sagu untuk pengeringan. Dengan integrasi teknologi fuzzy logic dan expert system, mesin ini dapat mengoptimalkan penggunaan energi surya dan gas secara efisien, dapat terlihat hasilnya 53% dari 100% lebih hemat dibanding non-hibrid.  Selain penghematan energi, biaya pengoperasian sistem hibrid lebih murah dari non-hibrid.  Kesimpulan, penerapan sistem hibrid surya-LPG pada alat pengering tipe kabinet dapat mengoptimalkan kinerja dan mengurangi konsumsi energi serta biaya operasional.
Introducing Indonesian endemism, its threat and conservation solution for SMA Negeri 10 students in Kamarian Village, West Seram Regency, Maluku
Authors: Leimena Handy Erwin Pier , Seumahu Cecilia Anna , Sahertian Dece Elizabeth , Ukratalo Abdul Mahid , Kaihena Martha
Published: March 2024

West Seram Regency on Seram Island in Maluku Province, Indonesia has extraordinary biodiversity and is the habitat of several endemic species of Maluku and Indonesia. As a form of implementation of the dharma of community service, socialization was conducted with students of SMA Negeri 10 in Kamarian Village, West Seram Regency, Maluku about Indonesian endemism, its threats and conservation. The socialization was attended by 38 students. The socialization results indicate that 91% of students demonstrated a good understanding of endemic species, and 82% of students obtained information on endemic species from this activity. Additionally, students were able to identify 11 Indonesian endemic species, as well as the threats and efforts to protect them. This activity has the potential to increase environmental awareness among school students, the nation's young generation.
Música para os Seus Ouvidos: Um Caso de Alucinose Musical Idiopática
Authors: Pereira Correia Joana Raquel , Fernandes Flores Tiago , Correia Costa Joana Filipa
Published: March 2024

A alucinose musical é uma doença com fisiopatologia mal-esclarecida, na qual a hipoacusia e as patologias do humor poderão ser fatores desencadeantes. Apesar de não existir uma abordagem terapêutica consensual, a psicoeducação desempenha um papel fulcral.Apresenta-se o caso de uma mulher de 84 anos de idade com hipoacusia e perturbação depressiva reativa ao papel de cuidadora do marido. Quatro dias após introdução de medicação antidepressiva iniciou quadro de alucinose musical auditiva, onde ouvia músicas da sua infância de forma contínua, ao longo do dia. Estas queixas mantiveram-se apesar da interrupção da terapêutica antidepressiva e mostraram-se refratárias à toma de antipsicóticos.Após despiste de patologias orgânicas foi iniciada psicoeducação, com enfoque no aumento da atividade social e estímulos auditivos e otimização das patologias co-mórbidas, tendo a doente apresentado evolução favorável e resolução quase completa das queixas.
“A rua é nóis": sobre a saudade da partilha do comum
Authors: Urpia Ana de Oliveira
Published: March 2024

Com base em uma experiência de atendimento psicológico on-line à mulheres negras quilombolas no contexto da pandemia, pretendemos: 1) refletir sobre casa e rua na realidade da população negra, guiados pelas noções de “forma social escravista” e de “re-territorialização”, ambas de Muniz Sodré, destacando, do interior dessas reflexões e a partir das elaborações teóricas de Carl Gustav Jung no campo da psicologia analítica, e de Achille Mbembe e Muniz Sodré no campo das relações étnico-raciais, dois conceitos em construção para a compreensão do sofrimento sociorracial: trauma racial e sombra branca; 2) refletir sobre o lugar da “partilha do comum” no cuidado à saúde mental da população negra de zonas rurais e urbanas. Do ponto de vista teórico-metodológico, trabalhamos ao modo de uma comunicação rapsódica, no sentido grego da palavra (raptein = coser): costurando história de caso e proposições conceituais.
Os eternos e constantes desafios do trabalho editorial
Authors: Silveira Maria Elisa Luiz da
Published: March 2024

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Virtual and experimental screening of new melatonin bioisosteres for the treatment of glaucoma
Authors: Babkov D. A. , Taran A. S. , Shevchenko A. A. , Naumenko L. V. , Zhukovskaya O. N. , Efremov A. M. , Bezsonova E. N. , Lozinskaya N. A. , Spasov A. A.
Published: March 2024

Background. Melatonin is an endogenous regulator of intraocular pressure (IOP), but its effectiveness as a drug for glaucoma treatment is limited.

The  aim of  the  study. To develop and  to  validate a  virtual screening method to identify bioisosteric analogs of melatonin that are promising for study as agents that reduce intraocular pressure.

Results. A database containing structural and experimental affinity information for 48 individual reference compounds was created. Risk assessments for mutagenic, carcinogenic, irritant and reproductive toxicity were performed in DataWarrior based on substructural analysis and identification of fragments that are markers of relevant toxicity. A virtual screening of 2457 structures was carried out and 25 compounds from the selected ones were experimentally studied for their effect on intraocular pressure (IOP) in intact rats. 10 of the 25 prioritized compounds were found to significantly reduce IOP; compound RU-398 reduced IOP by 40 %, K-165 – by 40.9 %, and RU-615 reduced glaucoma by 33.3 %.

Conclusion. The  effectiveness of  virtual screening after experimental validation was 40 %. The identified active compounds are promising for further study and development as the agents for the treatment of glaucoma.
Intraocular dirofilariasis: Surgical approaches, features of the clinical course (clinical case)
Authors: Arkhipov E. V. , Zaika V. A. , Kuzmin S. V. , Samsonov D. Yu. , Nefedieva M. D. , Zhuravskaya K. R.
Published: March 2024

The  aim. To  present a  clinical case of  surgical treatment of  parasitic invasion of the vitreous body caused by dirofilaria.

Material and methods. One patient with intraocular dirofilariasis got operated underwent surgical treatment including vitrectomy, phacoemulsification with implantation of an intraocular lens. At the stage of vitrectomy, a whole helminth was removed from the vitreal cavity using collet tweezers for subsequent typing. The uncorrected visual acuity of the right eye at the time of treatment was 0.4, of the left eye – 0.45.

Results. The  postoperative period had no  signs of  an  active inflammatory reaction. 4 months after surgical treatment, at a follow-up visit, visual acuity of the left eye reached 1.0. According to the parasitological study, a female Dirofilaria repens was identified. In the postoperative period, the areas of pronounced chorioretinal atrophy in the peripheral parts of the retina were visualized, which may be a consequence of mechanical contact of the parasite or the toxic effects of its metabolic products.

Conclusion. This  clinical example demonstrates the  possibility of  infection with the  ocular form of  dirofilariasis in  a  region that is  atypical for  the  presence of this helminth. Despite the positive outcome of the disease, in the presented patient, the long-term presence of the parasite in the vitreal cavity led to the formation of chorioretinal atrophy in the peripheral retina, which confirms the need for timely diagnosis and surgical treatment.
Effect of vaccination on morbidity and mortality from community-acquired pneumonia
Authors: Bayanova T. A. , Stukova E. S. , Kravchenko N. A.
Published: March 2024

Background. Community-acquired pneumonia remains one of the most common and life-threatening forms of pathology among respiratory diseases.

The aim of the study. To identify the features of the epidemiology of communityacquired pneumonia in the conditions of mass immunization against pneumococcal infection in the Irkutsk region.

Materials and methods. We conducted a descriptive epidemiological retrospective study. We studied the incidence of community-acquired pneumonia (including community-acquired pneumonia of bacterial and viral etiology) and mortality from this disease in the Irkutsk region for 2011–2022 according to statistical reporting forms No. 2, No. 5, No. 6, C51.

Results. The incidence of community-acquired pneumonia during the observation period remained at a high level: the long-term annual average rate among the total population was 627.3 [467.8÷786.8]. At the same time, there was a persistent decrease in the incidence of community-acquired pneumonia of bacterial etiology (Tdecrease = 6.8 %). Incidence rates of community-acquired pneumonia of bacterial etiology were distributed unevenly over  the  years and  the  compared population groups. The highest levels were recorded in children in 2018–2019 – 12.3 [10.8÷13.8] and 19.3 [17.8÷20.8], respectively. A decrease in the mortality rate from community-acquired pneumonia among children, adults and in the general population in 2020 was  shown, with a  subsequent increase in  the  rate among adults and  the  general population by  2.5  times. Against the  background of  ongoing immunization of the population against pneumococcal infection, there is a statistically significant decrease in the incidence of community-acquired pneumonia, including communityacquired bacterial pneumonia, and mortality from community-acquired pneumonia among different population groups.

Conclusion. Despite the high incidence of community-acquired pneumonia, a statistically significant decrease in the incidence of community-acquired pneumonia of  bacterial etiology has been shown among children and  adults. The  decrease in mortality from community-acquired pneumonia has continued since the introduction of immunization against pneumococcal infection. The results of the study can be used to optimize epidemiological surveillance and epidemiological control of community-acquired pneumonia at the regional level.
The role of L-arginine in the pathogenesis of essential arterial hypertension
Authors: Shcherbak V. A. , Medvedeva A. S. , Aksenova T. A. , Shcherbak N. M. , Aksenov K. O.
Published: March 2024

The role of arginine in the development of primary arterial hypertension continues to be clarified up to the present moment. During natural metabolic processes in cells, methylated forms of arginine are produced – symmetric (SDMA) and asymmetric (ADMA) dimethylarginine. ADMA is a nitric oxide synthase inhibitor and is now considered a well-established marker for endothelial dysfunction. SDMA is not a nitric oxide synthase inhibitor, but may indirectly reduce nitric oxide production through competitive interaction with cellular L-arginine.

Currently, arginine preparations are practically not used for the treatment of primary arterial hypertension. This was the rationale for the given scientific review. The article summarizes the information available in the literature (2018–2022) on the pathogenetic mechanisms of  the  relationship between arginine and  the  development of impaired vascular tone. We used PubMed and RSCI databases for our review. Using keywords, 1784 publications were found over the past 5 years. The final selection criteria were time frame and matching keywords. The review provides data on the increased ADMA concentrations in experimental hypertensive animals and individuals with essential hypertension. The role of arginine metabolites in the genesis of endothelial dysfunction and arterial hypertension and the prospects for the therapeutic use of this compound are discussed.
Biological properties and genetic structure of clinic isolates of Klebsiella pneumoniae species
Authors: Belkova N. L. , Klimenko E. S. , Nemchenko U. M. , Grigorova E. V. , Sitnikova K. O. , Zugeeva R. E. , Smurova N. E. , Chemezova N. N. , Savilov E. D.
Published: March 2024

Klebsiella pneumoniae (Kp) species complex is a genetically and ecologically diverse group of bacteria that causes a wide range of infections in humans and animals.

The aim. To carry out biological characterization and genotyping based on the study of different loci of Klebsiella pneumoniae clinical isolates.

Materials and  methods. The  object of  the study was  three Klebsiella pneumoniae clinical isolates from different biotopes of patients from a regional children’s multidisciplinary hospital. We used a complex of bacteriological, molecular genetic and bioinformatic methods. Genotyping of the isolates was carried out using the Pasteur Institute service for strains of the K. pneumoniae species complex.

Results. All strains were sensitive to antimicrobial drugs from carbapenem (imipenem, meropenem) and  tetracycline groups (tigecycline), and  demonstrated high sensitivity to the Klebsiella polyvalent bacteriophage. The antibiotic resistance of the Kp ODKB-16 and ODKB-81 isolates to seven and eight antimicrobial drugs, respectively, was registered

Based on  the results of  multi-locus sequence typing, all  strains were assigned to  Kp1  phylogroup, K2  type and  differed in  sequence type, scgMLST629  profile and KL type. Kp ODKB-16 strain was identified as ST-65, scgST-11107, KL2; ODKB-07 strain – as ST-219, scgST-6401, KL125KL114; ODKB-81 strain – as ST-86, scgST-2800, KL2KL30. The virulence gene clusters AbST, CbST, YbST, SmST, and RmST have been characterized only in the genome of the Kp ODKB-16 isolate, allowing it to be characterized as highly virulent with multidrug resistance (MDR). Additionally, genes responsible for the synthesis of types 1 and 3 fimbrial adhesins were registered in all strains, and ter operon loci were identified only in Kp ODKB-16. Resistome analysis showed that all strains had 2b genotype. Plasmids were found in the genomes of Kp ODKB-81 (IncI2) and ODKB-16 (IncFIA + IncFIB + IncHI1B).

Conclusion. We used a comprehensive framework for genomic taxonomy of clinical isolates, which can contribute to the unification of global and regional peculiarities of the developing and microevolution of bacterial pathogens.
Analisis Kesiapan Belajar Siswa pada Pembelajaran Perdiferensiasi
Authors: Juari Erwin Winaryati Dyah Ristanti Ari , Nugraheni Nursiwi
Published: March 2024

Penelitian yang dilaksanakan ini memiliki tujuan guna mendapatkan gambaran terkait kesiapan belajar peserta didik kelas II SDN Pesantren. Hasil yang diperoleh dari penelitian ini digunakan dalam menentukan aspek strategi pembelajaran berdiferensiasi yang tepat untuk digunakan secara menyeluruh dalam muatan pembelajaran. Penelitian yang dilaksanakan mempergunakan metode deskriptif kualitatif, mempergunakan teknik pengumpulan data angket, wawancara, serta observasi bersama guru kelas. Pada riset ini peneliti memakai subjek penelitian sebanyak 29 peserta didik kelas II SDN Pesantren. Perolehan hasil dari riset ini menunjukkan bahwa kesiapan belajar merupakan keadaan individu yang menyeluruh sehingga seseorang siap untuk memberikan tanggapan ataupun jawaban dalam situasi tertentu dalam hal ini adalah kesiapan belajar. Pada riset ini terbukti bahwa kesiapan belajar peserta didik menunjukkan 78,94% yang termasuk dalam kriteria tinggi, hasil kesiapan belajar tersebut dijadikan landasan dalam menerapkan strategi pembelajaran berdiferensiasi dengan memperhatikan 4 aspek berdiferensiasi. Implementasi pembelajaran berdiferensiasi terbukti memberikan pengaruh pada peningkatan kualitas pembelajaran yang mengarah pada tercapainya capaian pembelajaran dalam kurikulum merdeka.
Implementasi Kebijakan Kurikulum Merdeka pada Siswa-Siswi Sekolah Dasar
Authors: Veronica Hemalia , Hayat Hayat
Published: March 2024

Penelitian ini berfokus pada penerapan kebijakan pemerintah terkait kurikulum merdeka yang baru diterapkan di Sekolah Dasar pada tahun 2022 ini. Tujuan penelitian ini adalah untuk mengetahui pemulihan pendidikan yang ada di Indonesia terutama pada siswa-siswi sekolah dasar yang terkena dampak pandemi selama 2 tahun. Selain itu, peneliti juga ingin menganalisis seberapa efektif penerapan kurikulum tersebut. Metode yang digunakan dalam penelitian yaitu deskriptif kualitatif, yaitu metode menganalisis secara terperinci dan detail, sedangkan Teknik pengumpulan data yang digunakan yaitu studi pustaka dan wawancara dengan guru yang sudah menerapkan kurikulum merdeka di sekolahnya. Studi Pustaka atau studi literatur adalah Teknik pengumpulan data yang diambil dari literatur atau jurnal ilmiah yang relevan dan akurat. Hasil penelitian menunjukkan bahwa penerapan kurikulum merdeka sangat efektif diterapkan di Sekolah Dasar karena kurikulum tersebut berfokus pada penilaian karakter yang berlandaskan Pancasila dengan tujuan membentuk sumber daya manusia yang unggul. Sehingga hal tersebut menjadikan daya pengetahuan dan keterampilan siswa semakin meningkat karena mereka berfokus pada pengembangan literasi dan numerasi.
Kuinka koira puhutaan kasvisruokailijaksi? Diskurssianalyyttinen avaus monilajiseen elämäntyylipolitiikkaan
Authors: Malila Ville
Published: March 2024

Yhteiskuntatieteissä on tarkasteltu monipuolisesti kasvissyöntiä ja veganismia, mutta lähes unohdettu, ettemme ruoki vain omaa lajiamme. Joissain perheissä koiranruokavalinnoistakin on tullut keino tavoitella eläineettisempää ja kestävämpää yhteiskuntaa. Koiran ruokkiminen kasvisruoalla kyseenalaistaa vallitsevia koiranruoka- ja koirakäsityksiä, mikä vaatii artikkelissa analysoitua diskursiivista oikeuttamista. Selvitän kasvisruokkijoiden etähaastatteluilla kootun ja diskurssianalyyttisesti tarkastellun aineiston avulla, millaisilla diskursseilla kasvisruokintaa oikeutetaan ja miten koiran luontoa ja luonnollisuuksia määritellään niissä. Käsitteellistän koiran kasvisruokinnan veganismin monilajiseksi elämäntyylipolitiikaksi ja tarkastelen kasvisruokintaa perustelevaa puhetta monilajisen elämäntyylipolitikan diskursseina, jotka kyseenalaistavat eläinsuhteidemme itsestäänselvyyksiä ja karnismiksi kutsuttua liharuokaideologiaa. Tutkimus avaa, miten koiraa ja sen ruokintaa tulkitaan koira(kulutuksen) politisoituessa osana koiran pitäjän elämäntapaa Aineistosta erottamani koiran yhteiskunnallisuuden diskurssi, mikroskopisoituva ravitsemusdiskurssi ja koiran ruokinnan moraalisuuden diskurssi painottavat eri tavoin koiran ja koiranruoan yhteiskunnallisuutta. Niiden luonnollisuudet kyseenalaistuvat, kun koira kytketään diskursseissa ihmiseen lajina tai huollettavana ja koiran ravintoa ajatellaan lähteidensä sijaan ravintoaineina. Koiran ruokinnasta tulee näin ihmisen vastuulla ja muunneltavissa oleva yhteiskunnallinen kysymys ja elämäntyylipolitiikan monilajistuminen kytkeytyy koirasuhteiden muutoksiin myöhäismodernissa yhteiskunnassa. Veganismissa elämäntyyliliikkeen koira näyttäytyy lajityypillisesti kohdattuna mutta äänettömänä jäsenenä, jonka osallistumishalukkuutta ei tarvitse kysyä (ruokaherkkyyksiä lukuun ottamatta). Koira on nimittäin välttämättä huoltajansa kautta osallinen, riippumatta siitä, tiedostaako huoltaja osallisuuden ja koirakulutuksensa poliittisuuden. Tutkimus esittelee yhteiskuntatieteellistä eläintutkimusta elämäntyylipolitiikkakeskusteluihin nivovaa käsitteistöä ja hahmottelee mahdollisia koirakäsitysten muutoksia ympäristökatastrofeihin mukautuvissa yhteiskunnissa.
ANALYSING THE EFFECTIVENESS OF THE COMPUTER-AIDED DESIGN OF HYDRAULIC STATIONS
Authors: Orekhov Dmitry
Published: March 2024

The relevance of the research is due to the importance of investment costs for technical solutions to improve industrial enterprises’ management. Over the past decades, the installed capacity of metal-cutting machines has increased by an order of magnitude, which led to an even more active growth in their performance. Despite this, labour productivity as a whole has increased only several times. In such a situation, it is advisable to choose technologies that will be based on the precise identification of goals and expected results, grounded on considering production and technological conditions of manufacturing, assuming the possibility of using both cost and resource-time indicators of the production process. The aim of the article is to assess the economic effect of introducing a system of computer-aided design of hydraulic stations at enterprises related to producing volumetric hydraulic drive, to develop proposals to improve the economic and profitable performance of this production. The tools for achieving this goal are, first of all, management efficiency and time reduction for designing equipment, cost reduction at the initial stages of the equipment production. The economic results of introducing the computer-aided design system show the effectiveness of the proposed solutions.
DEVELOPMENT OF A BP-SCHEME MODEL BASED ON THE AUTOMATA THEORY AND USING QUANTUM PROGRAMMING METHODS
Authors: Belyaev Igor' , Petrov Aleksey , Popov Anton
Published: March 2024

The paper describes the concept of a new type of abstract automata “BP-scheme” (Business Process) that effectively distributes management commands between entities with their permanent growth in the paradigm of complexly modelled systems. The paper investigates the proposed model of the BP-scheme implementation, which is an artificial neural network, functioning based on fuzzy logic rules using the Takagi-Sugeno algorithm, for deriving rules in the form of functional dependencies. The model uses QPU (Quantum Processing Unit) in computing system behaviour, which implies a quick response to changes in the system entities. QPU used taking into account the developed rules of fuzzy neural network allows improving scenarios and predictive models of a complex system behaviour.
FORMALIZING ENTERPRISE’S BUSINESS PROCESSES WHEN MODELLING AN AUTOMATED CUSTOMER RELATIONSHIP MANAGEMENT SYSTEM
Authors: Bykova Anna , Bekmeshov Aleksandr
Published: March 2024

A pressing issue of automation and digitalization of processes in a manufacturing enterprise is the introduction of an automated customer relationship management system, namely a CRM system (Client Relationship Management System) into the structure of a functioning enterprise. The stage of in-depth study of the enterprise’s business processes, building the structure of business processes and modelling the future system allow one to significantly reduce the implementation time of the automated system, to clearly assess the compliance of the task and the future system, and to fulfil the effective implementation of a CRM system at a manufacturing enterprise. At the preliminary analysis stage, the issues of identifying the main entities of the system and determining the level of their interaction are resolved. The aim of the study is to describe the methodology for constructing a conceptual model of a CRM system using the example of conducting research on the structure of the enterprise’s business processes and further formalizing the results of preparatory work for the subsequent effective implementation of a CRM system. The main research methods are theoretical analysis, formalization and methods for constructing information models. The novelty of the work lies in examining poorly-studied aspects of the preliminary analysis when implementing CRM systems, identifying patterns in the description of typical non-production processes and their formalization for a functioning manufacturing enterprise. The study results can be used in designing the architecture, programming and setting up a CRM system at an enterprise in the field of mechanical engineering and other types of production.
DEVELOPING AN ALGORITHM FOR ASSESSING THE EFFECTIVENESS OF MEASURES AND MEANS OF PERSONAL DATA PROTECTION IN THE HEALTHCARE SECTOR
Authors: Sedakov Kirill , Rytov Mikhail
Published: March 2024

The features of existing directions and methods for assessing the effectiveness of information protection measures in medical institutions are considered. A comprehensive analysis of objects and identifying threats to the security of personal data is carried out. The authors identify key stages of the object research, consisting of determining the cost of information resources, identifying the most relevant threats, and calculating the damage from their application. The analysis of the possibility of implementing and eliminating threats is performed; a classification of the most critical threat groups is built. The main scientific result of the performed research states that this algorithm application is possible both for scientific purposes and for forming effective personal data protection systems in various organizations. Based on this, this study will lead to increasing the level of the effectiveness assessment for the protection measures of confidential information in medical organizations.
Can spinodal decomposition occur during decompression-induced vesiculation of magma?
Authors: Nishiwaki Mizuki
Published: March 2024

Volcanic eruptions are driven by decompression-induced vesiculation of supersaturated volatile components in magma. The initial phase of this phenomenon has long been described as a phase of nucleation and growth. Recently, it was proposed that spinodal decomposition (an energetically spontaneous phase separation that does not require the formation of a distinct interface) may occur during decompression-induced magma vesiculation. This suggestion has attracted considerable attention and is currently only based on qualitative textural observations of decompression experiment products (the independence of bubble number density on decompression rate; the homogeneous spatial distribution of the bubbles). In this study, I used a simple thermodynamic approach to quantitatively investigate whether spinodal decomposition can occur during the decompression-induced vesiculation of magma. I drew the binodal and spinodal curves for each magma on the chemical composition-pressure plane by approaching hydrous magmas at several conditions of temperature and chemical composition as two-component symmetric regular solutions of silicate and water, and using experimentally determined values of water solubility in these magmas. The spinodal curve was much lower than the binodal curve for all the magmas at pressures sufficiently below the second critical endpoint (approximately less than 1000 MPa). In addition, the final pressure of all the decompression experiments performed to date fell between these two curves. This suggests that spinodal decomposition is unlikely to occur in the pressure range of magmatic processes in the continental crust or at realistic decompression rates, and that decompression-induced magma vesiculation results from nucleation, as previously suggested. To test this thermodynamic approach, I estimated the ‘microscopic’ surface tension between the melt and the bubble nucleus in previous decompression experiments by substituting the pressure of the spinodal curve into the equation for the dependence of surface tension on the degree of supersaturation. The resulting values were significantly more scattered than those obtained by the conventional method of inversion of the experimental bubble number density using the classical nucleation theory formula. Therefore, it is difficult to judge whether the equation of surface tension as a factor of supersaturation (based on the nonclassical nucleation theory) is appropriate for magma systems. Further careful consideration should be given to both experimental and theoretical aspects of magma vesiculation.
But he’s our S.O.B.: Morally questionable actions of in-group members are more acceptable
Authors: McLaughlin Peter Joseph , Miller Bethany , Bechtold Jennifer , Bennett Elizabeth , Miller Chelsey
Published: March 2024

It is well-established that people favor members of their in-groups, and also protect and cooperate more with them, compared with out-groups. We investigated whether this differential treatment applied to how people evaluate morally questionable behavior of others. In two experiments, one exploratory and one pre-registered, participants viewed narratives that randomly varied the political, racial, national, or religious affiliation of actors who commit morally questionable actions (e.g., failing to help a fellow student struggling to carry books). As hypothesized, people gave greater approval to behavior of in-group members, compared with when the same action was taken by an out-group member. This seemed to be caused less by mere group identity, and more because of potential utility from supporting an in-group member. Surprisingly, however, effects were not stronger when the in-group was presented as under threat. People also tended to rate in-group members as better intentioned and less biased. The strongest effects were related to whether the act reflects upon the group. Questionable behavior from in-group members was seen as an individual action by a “bad apple,” while the same action committed by an out-group member reflected badly on the whole group. This finding may explain reluctance by individuals to rectify the bad behavior of members of their groups. Overall, these results identify a factor that may contribute to intergroup conflict, given that the same action can lead to moral outrage or a more muted response, depending on group affiliation.
Stage 1 Programmatic Registered Report: Open Scholarship and Feedback in Applied Research/Understanding the Role of Climate Change in Applied Research: A Qualitative Registered Report
Authors: Evans Thomas Rhys , Bartlett James Edward , Robertson Olly May , Pennington Charlotte Rebecca , Burns Calvin , Dean Laura , Bradley Kate , Henderson Emma Louise , Wang Ruijie , Gourdon-Kanhukamwe Amélie , Wilson-Lemoine Emma , Wilson-Lemoine Jérémy E. , Branney Peter , Butler Joanna , Kalandadze Tamara , Zaneva Mirela , Keller Elias , Giannouli Vaitsa , Hartmann Helena , Pfuhl Gerit , Maskell Jan , Graham Christopher James , O'Dwyer Emma Jane
Published: March 2024

This manuscript is a programmatic Registered Report that is expected to be the basis of two final manuscripts, one of which explores the feedback mechanisms applied researchers adopt in their work and the role of open scholarship in applied research, and the second that focuses upon climate change.
Navigating the Ship through Troubled Waters: The Success Story of an Authentic Sri Lankan Venture - Jack Fruit Ceylon (Pvt) Ltd
Authors: Wijewardene L. , Samarakoon S.M.G.P.K. , Rathnayake D.T. , Lakshika V.G.P. , Rajakaruna A.K.K. , Banduge R.H. , Sewwandi D.M.P. , Chathuranga B.T.K. , Jayawickrama W.D.C. , Dulanjana N.V.R.
Published: March 2024

People who see the world differently are the ones who change and develop the world. The Jack Fruit Ceylon (Pvt) Ltd is the realisation of the dream of a young visionary leader, Mr. Dulanjana Vithanage, who perceived the world differently as a budding Sri Lankan entrepreneur. This case study unfolds the challenging yet successful story of Mr. Dulanjana, who commits to achieving Sri Lanka's development goals through an authentic and morally responsible passion. This case study also delves into the challenges faced by Mr. Dulanjana and the strategic measures he took to navigate the business through the complexities of the current turbulent environment. Using his visionary insights, Mr. Dulanjana incorporated his dream enterprise, Jack Fruit Ceylon (Pvt) Ltd, which transformed the conventional tradition of jackfruit consumption in Sri Lanka by innovatively adding value to the wasted jackfruit surplus and turning it into an entrepreneurial triumph. The case study illustrates his divergent strategies, leadership, management capabilities and his passion for morality. Drawing extensively from insightful interviews with Mr. Dulanjana, this case study provides a comprehensive panorama of Jack Fruit Ceylon (Pvt) Ltd. It sheds light on the company's tenacity, spotlighting its journey of triumph over challenges in the volatile, uncertain, complex and ambiguous (VUCA) world, and emphasises its unwavering commitment to sustainability and innovation.
Beyond Boundaries: Blue Lotus 360°'s CSR Initiative with Mithuru Mithuro NGO – Nurturing Sustainability in the VUCA Landscape
Authors: Anuradha P. A. N. S. , Kaushalya G. A. T. , Rathnayake D. T. , Thalgaspitiya U. K. , Silva K. P. K. H. , Abeywickrama H. N. , Kalansuriya D. I. , Kulathunga K. M. H. N. M. , Weerakkody W. A. D. M. , Nadarajah Uthayakumar , Weerasooriya Dayal , Handapangoda Supun
Published: March 2024

Blue Lotus 360° (Pvt) Ltd is a Sri Lankan cloud-based Enterprise Resource Planning (ERP) software system provider. They specialize in offering a user-friendly web-based ERP solution for businesses of all sizes and industries. Blue Lotus 360° brings a wealth of experience and expertise to drive strategic initiatives. With a global presence and local offices, Blue Lotus 360° serves thousands of users and collaborates with strategic partners. By actively embracing Corporate Social Responsibility (CSR) and engaging in strategic partnerships, Blue Lotus 360° enhances its reputation and competitiveness in the market while prioritizing social and environmental concerns. Blue Lotus 360° stands to gain substantially by embracing CSR principles, establishing itself as a magnet for individuals who prioritize values and ethics in their professional journeys. Among various CSR initiatives of the Blue Lotus 360°, the implementation of the ERP system at Mithuru Mithuro (MM) stands out as a notable work. MM is a leading non-government organisation in Sri Lanka which provides rehabilitation facilities for drug addicts, covering three districts on the island with a total of over 800 residents in their care. Recognizing the technology’s pivotal role in enhancing operational efficiency and addressing the existing issues in the organization, the Board of Directors of the MM Movement selected Blue Lotus 360° (Pvt) Ltd to implement an ERP system as it is a pioneering company in providing software solutions in the dynamic landscape of the volatile, uncertain, complex and ambiguous (VUCA) world.