bluuebunny/crossref_metadata_2025 huggingface dataset:
Recrystallization and Micronization of p-Toluenesulfonamide Using the Rapid Expansion of Supercritical Solution (RESS) Process
Authors: Yang Tsung-Mao , Su Chie-Shaan , Li Jin-Shuh , Lu Kai-Tai , Yeh Tsao-Fa
Published: August 2019

This study is focused on the micronization of p-toluenesulfonamide (p-TSA) using the rapid expansion of supercritical solution (RESS) process. Taguchi’s experimental design method was applied to determine the optimum operating conditions. L9(34) orthogonal array with four control factors and three levels of each control factor was used to design nine experimental conditions. Four control factors were selected, including extraction temperature, extraction pressure, pre-expansion temperature, and post-expansion temperature. The particle size and morphology of the prepared samples were observed by scanning electron microscopy (SEM). In addition, Fourier transform infrared spectrometer (FTIR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC) were employed to compare the differences between the raw and micronized p-TSA particles. The experimental and analytical results indicated that the extraction temperature was the most significant factor for the micronization of p-TSA in the RESS process, and the optimal operating conditions were at an extraction temperature of 50 °C, an extraction pressure of 220 MPa, a pre-expansion temperature of 220 °C, and a post-expansion temperature of 30 °C. The p-TSA particles were micronized from the original average size of 294.8 μm to the smallest average size of 1.1 μm at the optimal RESS process conditions. Furthermore, the physicochemical characteristics of p-TSA did not differ significantly before and after recrystallization.
Design of a Solid-State Circuit Breaker for a DC Grid-Based Vessel Power System
Authors: Tapia Lukas , Baraia-Etxaburu Igor , Valera Juan José , Sanchez-Ruiz Alain , Abad Gonzalo
Published: August 2019

Electric propulsion and integrated hybrid power systems can improve the energy efficiency and fuel consumption of different kinds of vessels. If the vessel power system is based on DC grid distribution, some benefits such as higher generator efficiency and lower volume and cost can be achieved. However, some challenges remain in terms of protection devices for this kind of DC grid-based power system. The absence of natural zero crossing in the DC current together with the fast and programmable breaking times required make it challenging. There are several papers related to DC breaker topologies and their role in DC grids; however, it is not easy to find comprehensive information about the design process of the DC breaker itself. In this paper, the basis for the design of a DC solid-state circuit breaker (SSCB) for low voltage vessel DC grids is presented. The proposed SSCB full-scale prototype detects and opens the fault in less than 3 µs. This paper includes theoretical analyses, design guidelines, modeling and simulation, and experimental results.
Review of Channel Estimation for Candidate Waveforms of Next Generation Networks
Authors: Ijiga Owoicho E. , Ogundile Olayinka O. , Familua Ayokunle D. , Versfeld Daniel J. J.
Published: August 2019

The advancement in wireless communication applications encourages the use of effective and efficient channel estimation (CE) techniques because of the varying behaviour of the Rayleigh fading channel. In most cases, the emphasis of most proposed CE schemes is to improve the CE performance and complexity for ensuring quality signal reception and improved system throughput. Candidate waveforms whose designs are based on filter bank multi-carrier (FBMC) modulation techniques such as filter bank orthogonal frequency division multiplexing based on offset quadrature amplitude modulation (OFDM-OQAM), universal filtered multicarrier (UFMC) and generalised frequency division multiplexing based on offset quadrature amplitude modulation (GFDM-OQAM) are no exception to the use of these proposed CE techniques in the literature. These schemes are considered as potential waveform candidates for the physical/media access control layer of the emerging fifth generation (5G) networks. Therefore, pinpoint CE techniques represent an important requirement for these waveforms to attain their full potentials. In this regard, this paper reviews the concept of CE as applicable to these waveforms as well as other waveform candidates under consideration in the emerging 5G networks. Since the design of the majority of the waveform candidates is filter based, a review of the general filter design considerations is presented in this paper. Secondly, we review general CE techniques for candidate waveforms of next generation networks and classify some of the studied CE techniques. In particular, we classify the CE schemes used in filter bank OFDM-OQAM and GFDM-OQAM based transceivers and present a performance comparison of some of these CE schemes. Besides, the paper reviews the performances of two linear CE schemes and three adaptive based CE schemes for two FBMC based waveform candidates assuming near perfect reconstruction (NPR) and non-perfect reconstruction (Non-PR) filter designs over slow and fast frequency selective Rayleigh fading channels. The results obtained are documented through computer simulations, where the performances of the studied CE schemes in terms of the normalised mean square error (NMSE) are analysed. Lastly, we summarise the findings of this work and suggest possible research directions in order to improve the potentials of the studied candidate waveforms over Rayleigh fading channels.
Programming Protocol-Independent Packet Processors High-Level Programming (P4HLP): Towards Unified High-Level Programming for a Commodity Programmable Switch
Authors: Hang Zijun , Wen Mei , Shi Yang , Zhang Chunyuan
Published: August 2019

Network algorithms are building blocks of network applications. They are inspired by emerging commodity programmable switches and the Programming Protocol-Independent Packet Processors (P4) language. P4 aims to provide target-independent programming neglecting the architecture of underlying infrastructure. However, commodity programmable switches have tight programming restrictions due to limited resources and latency. In addition, manufacturers tailor P4 according to their architecture, putting more restrictions on it. These intrinsic and extrinsic restrictions dilute the goal of P4. This paper proposes P4 high-level programming (P4HLP) framework, a suite of toolchains that simplifies P4 programming. The paper highlights three aspects: (i) E-Domino, a high-level programming language that defines both stateless and stateful processing of data plane in C-style codes; (ii) P4HLPc, a compiler that automatically generates P4 programs from E-Domino programs, which removes the barrier between high-level programming and low-level P4 primitives; (iii) modular programming that organizes programs into reusable modules, to enable fast reconfiguration of commodity switches. Results show that P4HLPc is efficient and robust, thus is suitable for data plane high-level programming. Compared with P4, E-Domino saves at least 5.5× codes to express the data plane algorithm. P4HLPc is robust to policy change and topology change. The generated P4 programs achieve line-rate processing.
Dynamic Viscosity, Surface Tension and Wetting Behavior Studies of Paraffin–in–Water Nano–Emulsions
Authors: Cabaleiro David , Hamze Samah , Agresti Filippo , Estellé Patrice , Barison Simona , Fedele Laura , Bobbo Sergio
Published: August 2019

This work analyzes the dynamic viscosity, surface tension and wetting behavior of phase change material nano–emulsions (PCMEs) formulated at dispersed phase concentrations of 2, 4 and 10 wt.%. Paraffin–in–water samples were produced using a solvent–assisted route, starting from RT21HC technical grade paraffin with a nominal melting point at ~293–294 K. In order to evaluate the possible effect of paraffinic nucleating agents on those three properties, a nano–emulsion with 3.6% of RT21HC and 0.4% of RT55 (a paraffin wax with melting temperature at ~328 K) was also investigated. Dynamic viscosity strongly rose with increasing dispersed phase concentration, showing a maximum increase of 151% for the sample containing 10 wt.% of paraffin at 278 K. For that same nano–emulsion, a melting temperature of ~292.4 K and a recrystallization temperature of ~283.7 K (which agree with previous calorimetric results of that emulsion) were determined from rheological temperature sweeps. Nano–emulsions exhibited surface tensions considerably lower than those of water. Nevertheless, at some concentrations and temperatures, PCME values are slightly higher than surface tensions obtained for the corresponding water+SDS mixtures used to produce the nano–emulsions. This may be attributed to the fact that a portion of the surfactant is taking part of the interface between dispersed and continuous phase. Finally, although RT21HC–emulsions exhibited contact angles considerably inferior than those of distilled water, PCME sessile droplets did not rapidly spread as it happened for water+SDS with similar surfactant contents or for bulk–RT21HC.
Vulnerability Assessment of Korean Electric Power Systems to Late-Time (E3) High-Altitude Electromagnetic Pulses
Authors: Kim Soobae , Jeong Injoo
Published: August 2019

High-altitude electromagnetic pulses (HEMPs) are bursts of electromagnetic energy that result from nuclear weapon detonations at altitudes at or above 30 km. A HEMP is comprised of three components: E1, E2, and E3. E1 and E2 are instantaneous emissions that can damage electronic components, whereas E3 generates low-frequency, geomagnetically-induced currents in transmission lines and power transformers. These currents can lead to the half-cycle saturation of power transformers and increased reactive power consumption. This study assessed the impact of the E3 HEMP on Korean electric power systems. For this assessment, two publicly available E3 HEMP environments were identified. A Direct Current (DC)equivalent model of Korean power systems was developed to calculate the geomagnetically-induced currents and increased the reactive power absorption of transformers in power systems. The vulnerability assessment involved two types of analysis: Static power flow analysis and dynamic transient stability analysis. The maximum electric field limit was determined by performing a steady-state analysis. The capability of the Korean electric power systems to maintain synchronism and acceptable voltages in the transient stability time frame following an E3 HEMP event was evaluated. Furthermore, the effects of detonations at five target locations were compared. It was concluded that Korean electric power systems cannot maintain their stability when affected by an E3 HEMP.
Incorporating Location Aspects in Process Integration Methodology
Authors: Bütün Hür , Kantor Ivan , Maréchal François
Published: August 2019

The large potential for waste resource and heat recovery in industry has been motivating research toward increasing efficiency. Process integration methods have proven to be effective tools in improving industrial sites while decreasing their resource and energy consumption; however, location aspects and their impact are generally overlooked. This paper presents a method based on process integration, which considers the location of plants. The impact of the locations is included within the mixed integer linear programming framework in the form of heat losses, temperature and pressure drop, and piping cost. The objective function is selected as minimisation of the total cost of the system excluding piping cost and ϵ -constraints are applied on the piping cost to systematically generate multiple solutions. The method is applied to a case study with industrial plants from different sectors. First, the interaction between two plants and their utility integration are illustrated, depending on the piping cost limit which results in the heat pump and boiler on one site being gradually replaced by excess heat recovered from the other plant. Then, the optimisation of the whole system is carried out, as a large-scale application. At low piping cost allowances, heat is shared through high pressure steam in above-ground pipes, while at higher piping cost limits the system switches toward lower pressure steam sharing in underground pipes. Compared to the business-as-usual operation of the sites, the optimal solution obtained with the proposed method leads to 20% reduction in the overall cost of the system, including the piping cost. Further reduction in the cost is possible using a state of the art method but the technical and economic feasibility is not guaranteed. Thus, the present work provides a tool to find optimal industrial symbiosis solutions under different investment limits on the infrastructure between plants.
Game-Based Hierarchical Cooperative Control for Electric Vehicle Lateral Stability via Active Four-Wheel Steering and Direct Yaw-Moment Control
Authors: Zhao Lin , Lu Shaobo , Zhang Bohan
Published: August 2019

A Stackelberg game-based cooperative control strategy is proposed for enhancing the lateral stability of a four-wheel independently driving electric vehicle (FWID-EV). An upper‒lower double-layer hierarchical control structure is adopted for the design of a stability control strategy. The leader‒follower-based Stackelberg game theory (SGT) is introduced to model the interaction between two unequal active chassis control subsystems in the upper layer. In this model, the direct yaw-moment control (DYC) and the active four-wheel steering (AFWS) are treated as the leader and the follower, respectively, based on their natural characteristics. Then, in order to guarantee the efficiency and convergence of the proposed control strategy, a sequential quadratic programming (SQP) algorithm is employed to solve the task allocation problem among the distributed actuators in the lower layer. Also, a double-mode adaptive weight (DMAW)- adjusting mechanism is designed, considering the negative effect of DYC. The results of cosimulation with CarSim and Matlab/Simulink demonstrate that the proposed control strategy can effectively improve the lateral stability by properly coordinating the actions of AFWS and DYC.
Investigation of Wheelhouse Flow Interaction and the Influence of Lateral Wheel Displacement
Authors: Rajaratnam Eleanor , Walker Duncan
Published: August 2019

The aim of this research was to improve the understanding of the complex flow features found around a wheel and wheelhouse and to examine how the lateral displacement of the wheel affects these features and the production of exhibited pressures and forces. A bespoke rotating wheel rig and accompanying wheelhouse with a fully-pressure-tapped wheel arch was designed and manufactured at Loughborough University. Wind tunnel tests were performed where force and pressure measurements and Particle Image Velocimetry (PIV) data were obtained. The experimental data was used to validate unsteady CFD predictions where a k- ω SST Improved Delayed Detached Eddy Simulation (IDDES) turbulence model was used in STAR-CCM+ (10.04.009, Siemens). The CFD showed good agreement with all trends of the experimental results providing a validated numerical methodology. For both methodologies, a lower amount of wheelhouse drag was found generated when the wheel was rotating. However, the CFD showed that whilst this was the case, total configuration drag had increased. This was attributed to an increase of the wheel and axle drag, illustrated by the change in separation over the wheel itself when located within a wheelhouse and so overcompensating the reduction in body and stand drag. Differences in vortex locations when comparing to previously-attained results were due to differences in housing geometry, such as blockage in the cavity or housing dimensions. Experimental and computational results showed that up until a 10 mm displacement outboard of the housing, overall drag decreased. The reduction in housing drag was credited to a reduction in the size of outboard longitudinal vortex structures. This led to the lateral width of the shear layer across the housing side being narrower. Overall, this study identified that there were potential benefits to be gained when offsetting a wheel outboard of the longitudinal edge of a model housing.
Delay by Spin-Up of Captive Vortex
Authors: Tesař Václav
Published: August 2019

Recent application of fluidics show increasing importance with respect to signals encoded in flow pulses, in oscillators as well as in closely related devices for correcting the distorted pulse shapes. The parameters of the pulses are adjusted using the output of the fluidic circuits generating the time delays. Currently they are mostly based on the speed of the flow propagation channels. This paper focuses on a much less known delay principle, based on the dynamics of spin-up of a vortex rotating inside a closed cavity and shows some simple fluidic circuits using this principle. Apart from an experimentally investigated model, the manuscript also contains a simple theory for the captive vortex dynamics.
Comparison of Natural Regeneration in Natural Grassland and Pine Plantations across an Elevational Gradient in the Páramo Ecosystem of Southern Ecuador
Authors: Quiroz Dahik Carlos , Marín Franklin , Arias Ruth , Crespo Patricio , Weber Michael , Palomeque Ximena
Published: August 2019

During the 1980s, reforestation programs using exotic species (Pinus spp.) were established in the páramo ecosystem of Ecuador. The aims of this study were: (1) to compare the natural regeneration between pine plantations (Pi) and natural grassland (NG) across an elevational gradient and (2) to identify the attributes of Pi and soil properties that were influencing herbaceous and woody plant composition and their plant cover. In total, six independent Pinus patula (Schltdl. & Cham. plantations (two per each elevation) were selected and distributed in an elevational range (3200–3400, 3400–3600, 3600–3800 m a.s.l.). Adjacent to Pi, plots in NG were established for recording natural regeneration. Both, namely the attributes and the soil samples, were measured in Pi. The results showed that natural regeneration differs significantly between both types of vegetation. As expected, NG holds more plant diversity than Pi; the elevational range showed a clear tendency that there was more herbaceous richness when elevation range increases, while the opposite was found for woody species. Moreover, attributes of Pi influenced herbaceous and woody vegetation, when saturated hydraulic conductivity (Ksat) in the soil, basal area (BA) and canopy density (CD) increased, herbaceous species richness and its cover decreseased; and when Ksat and the acidity in the soil increased, woody plants richness and its cover decreased. The plantations have facilitated the establishment of shade tolerant species. More studies are needed to evaluate if removal with adequate management of pine plantations can improve the restoration and conservation of the native vegetation of the páramo ecosystem.
Rapid and Cost-Efficient Enterovirus Genotyping from Clinical Samples Using Flongle Flow Cells
Authors: Grädel Carole , Terrazos Miani Miguel Angel , Barbani Maria Teresa , Leib Stephen L , Suter-Riniker Franziska , Ramette Alban
Published: August 2019

Enteroviruses affect millions of people worldwide and are of significant clinical importance. The standard method for enterovirus identification and genotyping still relies on Sanger sequencing of short diagnostic amplicons. In this study, we assessed the feasibility of nanopore sequencing using the new flow cell “Flongle” for fast, cost-effective, and accurate genotyping of human enteroviruses from clinical samples. PCR amplification of partial VP1 gene was performed from multiple patient samples, which were multiplexed together after barcoding PCR and sequenced multiple times on Flongle flow cells. The nanopore consensus sequences obtained from mapping reads to a reference database were compared to their Sanger sequence counterparts. Using clinical specimens sampled over different years, we were able to correctly identify enterovirus species and genotypes for all tested samples, even when doubling the number of barcoded samples on one flow cell. Average sequence identity across sequencing runs was >99.7%. Phylogenetic analysis showed that the consensus sequences achieved with Flongle delivered accurate genotyping. We conclude that the new Flongle-based assay with its fast turnover time, low cost investment, and low cost per sample represents an accurate, reproducible, and cost-effective platform for enterovirus identification and genotyping.
Two Years of Viral Metagenomics in a Tertiary Diagnostics Unit: Evaluation of the First 105 Cases
Authors: Kufner Verena , Plate Andreas , Schmutz Stefan , Braun Dominique L. , Günthard Huldrych F. , Capaul Riccarda , Zbinden Andrea , Mueller Nicolas J. , Trkola Alexandra , Huber Michael
Published: August 2019

Metagenomic next-generation sequencing (mNGS) can capture the full spectrum of viral pathogens in a specimen and has the potential to become an all-in-one solution for virus diagnostics. To date, clinical application is still in an early phase and limitations remain. Here, we evaluated the impact of viral mNGS for cases analyzed over two years in a tertiary diagnostics unit. High throughput mNGS was performed upon request by the treating clinician in cases where the etiology of infection remained unknown or the initial differential diagnosis was very broad. The results were compared to conventional routine testing regarding outcome and workload. In total, 163 specimens from 105 patients were sequenced. The main sample types were cerebrospinal fluid (34%), blood (33%) and throat swabs (10%). In the majority of the cases, viral encephalitis/meningitis or respiratory infection was suspected. In parallel, conventional virus diagnostic tests were performed (mean 18.5 individually probed targets/patients). mNGS detected viruses in 34 cases (32%). While often confirmatory, in multiple cases, the identified viruses were not included in the selected routine diagnostic tests. Two years of mNGS in a tertiary diagnostics unit demonstrated the advantages of a single, untargeted approach for comprehensive, rapid and efficient virus diagnostics, confirming the utility of mNGS in complementing current routine tests.
Glass Crystal Models: A First Approach to a Hidden Treasure of Teaching and Scientific Heritage
Authors: Peixe Carolina , Casanova Conceição , Lia Ferreira Joana , Coutinho Inês
Published: August 2019

Glass crystal models arrived in Portugal around the late 19th century, when high schools, universities, and polytechnics were gradually provided with teaching collections to support science education. Therefore, they are an important material evidence of teaching methodologies of mineral and geology science in the 20th century. The Passos Manuel high school in Lisbon, owns a significant collection of scientific heritage, currently on a long-term loan at the National Museum of Natural History and Science and the University of Lisbon, which includes a set of 98 glass crystal models. Besides glass, these models are composed by adhesives, paper, cardboard, textile threads, paper/textile adhesive tapes, and metal nuts and screws. Also, they show several levels of intervention and different conservation states. In this paper, the first results of a multi-analytic approach to chemically characterize these objects’ material composition will be presented. Characterization was done based on portable equipment (pXRF), or by collecting small samples further analyzed using optical microscopy and FTIR-ATR techniques. This study allowed for a first distinction between original materials from the old repairs; to develop a more accurate assessment of the conservation condition; and finally, as one of the main aims of this work, to determine preventive conservation measures in order to better preserve these cultural objects.
Interactive Effects of Sertraline and Diphenhydramine on Biochemical and Behavioral Responses in Crucian Carp (Carassius auratus)
Authors: Xie Zhengxin , Lu Guanghua
Published: August 2019

The ecotoxicity of psychiatric pharmaceuticals to aquatic organisms is being increasingly recognized. However, current ecological studies focus on the effects of individual psychiatric pharmaceuticals, with little attention being given to their combined effects. In this study, the interactive effects of two psychiatric pharmaceuticals, sertraline (SER) and diphenhydramine (DPH), on bioconcentration and biochemical and behavioral responses were investigated in crucian carp (Carassius auratus) after seven days of exposure. DPH was found to increase the accumulation of SER in fish tissues relative to SER-alone exposure. In addition, the mixture of SER and DPH significantly changed the activities of antioxidant enzymes and led to significant increases in malondialdehyde content, relative to SER alone. Concerning the neurotoxicity, relative to SER-alone exposure, brain AChE activity was significantly enhanced in fish following the combined exposure. Regarding behavioral responses, swimming activity and shoaling behavior were significantly altered in co-exposure treatments compared with the SER alone. Moreover, the inhibition effects on the feeding rates were increased in co-exposure treatments compared to SER alone. Collectively, our results suggest that the mixtures of psychiatric pharmaceuticals may pose more severe ecological risks to aquatic organisms compared to these compounds individually.
An Intervention to Improve Uptake of Referrals for Children with Ear Disease or Hearing Loss in Thyolo District, Malawi: Acceptability and Feasibility
Authors: Baum Antonia , Mulwafu Wakisa , Phiri Mwanaisha , Polack Sarah , Bright Tess
Published: August 2019

(1) Introduction: Poor uptake of referral for ear and hearing services in Malawi has been demonstrated in previous research. A multi-component educational intervention was developed to address poor uptake. The aim of this study was to explore the feasibility and acceptability of the intervention. In addition, we aimed to provide a case study of an intervention development and feasibility testing process in preparation for a potential randomised trial. (2) Methods: The intervention included three components: (i) an information booklet; (ii) personalised counselling by a community health worker and an expert mother; (iii) a text message reminder. To assess feasibility, the counselling and information booklet were provided for caregivers of eligible children (<18 years) at ear and hearing outreach camps in Thyolo. Text message reminders were sent to caregivers after the camps. After 4 weeks, all caregivers were revisited and completed a structured questionnaire and a subset were interviewed in-depth. (3) Results: 30 children were recruited, and 53% took up the referral. Interviews found counselling with a booklet was acceptable. It provided motivation, enabled a two-way conversation, and helped dispel fear. It allowed information to be shared with social networks, initiating conversations about raising funds. The text message reminder was reported to be a valued prompt. Challenges to feasibility included low network coverage, and time needed for counselling. Residual barriers included the costs of transportation. The cost was £3.70/camp. (4) Conclusions: The study found that counselling with an information booklet was feasible and acceptable. The process of testing the feasibility of the intervention identified some adaptations to the intervention components and delivery which could be implemented before it is tested in a trial. This study highlighted the value of the feasibility testing process.
Risk of Seizures in Patients with Organophosphate Poisoning: A Nationwide Population-Based Study
Authors: Chuang Chieh-Sen , Yang Kai-Wei , Yen Chia-Ming , Lin Cheng-Li , Kao Chia-Hung
Published: August 2019

Objective: Previous research has demonstrated that patients with a history of organophosphate poisoning tend to have a higher risk of neurological disorder. However, research on the rate of seizure development in patients after organophosphate poisoning is lacking. This study examined whether individuals with organophosphate poisoning have an increased risk of seizures through several years of follow-up. Patients and Methods: We conducted a retrospective study on a cohort of 45,060 individuals (9012 patients with a history of organophosphate poisoning and 36,048 controls) selected from the Taiwan National Health Insurance Research Database. The individuals were observed for a maximum of 12 years to determine the rate of new-onset seizure disorder. We selected a comparison cohort from the general population that was randomly frequency-matched by age, sex, and index year and further analyzed the risk of seizures using a Cox regression model adjusted for sex, age, and comorbidities. Results: During the study period, the risk of seizure development was 3.57 times greater in patients with organophosphate poisoning compared with individuals without, after adjustments for age, sex, and comorbidities. The absolute incidence of seizures was highest in individuals aged 20 to 34 years in both cohorts (adjusted hazard ratio = 13.0, 95% confidence interval = 5.40−31.4). A significantly higher seizure risk was also observed in patients with organophosphate poisoning and comorbidities other than cirrhosis. Conclusions: This nationwide retrospective cohort study demonstrates that seizure risk is significantly increased in patients with organophosphate poisoning compared with the general population.
Association of Depression and Excessive Daytime Sleepiness among Sleep-Deprived College Freshmen in Northern Taiwan
Authors: Tsou Meng-Ting , Chang Betty Chia-Chen
Published: August 2019

Background. The aim of this study was to investigate depression and other determinants (sleep-deprived behaviors such as hours spent sleeping, watching television, and on the computer) and their association with excessive daytime sleepiness (EDS) among college freshmen. Methods. Self-administered questionnaires were collected from two colleges in northern Taiwan from July to September 2014. A total of 2643 students (38.7% male; ages ranged 18–23 years; mean age of 18.8 ± 1.2 years) completed an anonymous questionnaire on lifestyle behaviors (including personal habits, sleep duration and quality, and hours spent watching television and on the computer); perception of one’s health, a validated depression scale (Brief Symptom Rating Scale, BSRS-5); insomnia symptoms (the Chinese version of the Athens Insomnia Scale, CAIS); and EDS rated with the Chinese Epworth sleepiness scale (CESS). The data were analyzed using the chi-squared test, t-test, multivariate logistic regression, and multiple linear regression. Results. The prevalence of EDS among college students was approximately 27.1% (717/2643). The risk of EDS was elevated with increasing severity of depression: odds ratio (OR) = 2.8/3.71/5.01 for female, and OR = 3.29/5.07/5.07 for mild/moderate/severe depression for male, respectively (p < 0.05; marginally higher in male severe depression, p = 0.08). If depression score increased by 1 point, CESS score increased by 0.35 point; if time spent on the computer during non-holidays increased by 1 h, CESS score increased by 0.1 point; and for those whose sleep duration increased by 1 h during non-holidays, CESS score decreased by 0.1 point. Conclusions. EDS significantly predicted depression among college freshmen. Using a computer for a long time and less sleep duration during non-holidays contributed to EDS of college freshmen. Youths who experience EDS are recommended to seek assessment for depression symptoms and sleep-deprived behaviors, thus allowing physicians to offer appropriate screening and treatment.
Deliberate Self-Harm Among Chinese Children with Different Types and Severity of Disabilities
Authors: Zhu Huiping , Abudusaimaiti Xiayidanmu , Xiang Joe , Gao Qi
Published: August 2019

Background: The aims of this study were to determine the prevalence of deliberate self-harm (DSH) and to compare the risk of self-harm in Chinese children with different types and severity of disabilities. Methods: Participants were 1300 children aged 6–17 years in Beijing, China; 650 children with disabilities and 650 healthy peers matched on age, gender and residence district. Questionnaires were completed anonymously by parents or children if the age or disability made it necessary. The associations between the disability type, severity and DSH were examined using the Chi-square testing and logistic regression models. Results: Children with a single disability or multiple disabilities had statistically higher rates of DSH than children without disabilities (15.6% and 39.7% compared to 10.9%). The prevalence of DSH was associated with the severity of disability, being 36.2% among children with level 1 (the most severe) disability, 19.8% among children with level 2 disability, and 9.2% among children with level 3 + 4 disability. The multivariable odds ratio (OR) of DSH among children with any disability was statistically higher than that among children without a disability (OR = 2.40; 95% CI = 1.71, 3.36; p < 0.05). Children with multiple disabilities (OR = 6.89; 95% CI: 4.24–11.20) and level 1 severity of disability (OR = 6.11; 95% CI: 3.91–9.56) had the highest risk of DSH. Conclusions: This study clearly demonstrated associations between the severity and type of disability and DSH. This finding highlights the importance of DSH in children with disabilities, and underlines the importance of the prevention of DSH among a vulnerable pediatric population in China.
A Citizen Science Approach to Determine Physical Activity Patterns and Demographics of Greenway Users in Winston-Salem, North Carolina
Authors: Dilley Joshua R. , Moore Justin B. , Summers Phillip , Price Amanda A. , Burczyk Matthew , Byrd Lynn , Sisson Patricia J. , Bertoni Alain G.
Published: August 2019

Citizen science is a growing method of scientific discovery and community engagement. To date, there is a paucity of data using citizen scientists to monitor community level physical activity, such as bicycling or walking; these data are critical to inform community level intervention. Volunteers were recruited from the local community to make observations at five local greenways. The volunteers picked their location, time to collect data and duration of data collection. Volunteer observations included recording estimated age, race or ethnicity and activity level of each individual they encountered walking, running or bicycling on the greenway. A total of 102 volunteers were recruited to participate in the study, of which 60% completed one or more observations. Average observational time lasted 81 minutes and resulted in recording the demographics and physical activity of a mean of 48 people per session. The majority of adult bicyclists observed were biking at a moderate pace (86%) and were white (72%) males (62%). Similar results were observed for those walking. We demonstrate the feasibility of using citizen scientists to address the current scarcity of data describing community-level physical activity behavior patterns. Future work should focus on refining the citizen science approach for the collection of physical activity data to inform community-specific interventions in order to increase greenway use.
Healthy or Unhealthy? The Cocktail of Health-Related Behavior Profiles in Spanish Adolescents
Authors: Sevil-Serrano Javier , Aibar-Solana Alberto , Abós Ángel , Julián José Antonio , García-González Luis
Published: August 2019

The aim of this study was to identify the prevalence and clustering of health-related behaviors in Spanish adolescents and to examine their association with sex, body mass index (BMI), different types of sedentary screen time, and adherence to 24-hour movement guidelines. A final sample of 173 students (M = 12.99 ± 0.51) participated in this study. Cluster analysis was conducted based on five health-related behaviors: PA and sedentary time derived from accelerometers, as well as healthy diet, sedentary screen time, and sleep duration derived from self-reported scales. Recommendations for 24-hour movement guidelines (i.e., physical activity (PA), screen time, and sleep duration) were analyzed both independently and combined. A total of 8.9% of the sample did not meet any of the guidelines, whereas 72.3%, 17.3%, and 1.7% of the sample met 1, 2, or all 3 guidelines, respectively. Six distinct profiles were identified, most of them showing the co-occurrence of healthy- and unhealthy-related behaviors. Given that most of the adolescents failed to meet the combination of PA, screen time, and sleep duration guidelines, these findings suggest the necessity to implement school-based interventions that target multiple health behaviors, especially because (un)healthy behaviors do not always cluster in the same direction.
Enablers and Barriers to the Utilization of Antenatal Care Services in India
Authors: Ogbo Felix Akpojene , Dhami Mansi Vijaybhai , Ude Ebere Maureen , Senanayake Praween , Osuagwu Uchechukwu L. , Awosemo Akorede O. , Ogeleka Pascal , Akombi Blessing Jaka , Ezeh Osita Kingsley , Agho Kingsley E.
Published: August 2019

Antenatal care (ANC) reduces adverse health outcomes for both mother and baby during pregnancy and childbirth. The present study investigated the enablers and barriers to ANC service use among Indian women. The study used data on 183,091 women from the 2015–2016 India Demographic and Health Survey. Multivariate multinomial logistic regression models (using generalised linear latent and mixed models (GLLAMM) with the mlogit link and binomial family) that adjusted for clustering and sampling weights were used to investigate the association between the study factors and frequency of ANC service use. More than half (51.7%, 95% confidence interval (95% CI): 51.1–52.2%) of Indian women had four or more ANC visits, 31.7% (95% CI: 31.3–32.2%) had between one and three ANC visits, and 16.6% (95% CI: 16.3–17.0%) had no ANC visit. Higher household wealth status and parental education, belonging to other tribes or castes, a woman’s autonomy to visit the health facility, residence in Southern India, and exposure to the media were enablers of the recommended ANC (≥4) visits. In contrast, lower household wealth, a lack of a woman’s autonomy, and residence in East and Central India were barriers to appropriate ANC service use. Our study suggests that barriers to the recommended ANC service use in India can be amended by socioeconomic and health policy interventions, including improvements in education and social services, as well as community health education on the importance of ANC.
Factors Associated with Practice-Level Performance Indicators in Primary Health Care in Hungary: A Nationwide Cross-Sectional Study
Authors: Kovács Nóra , Pálinkás Anita , Sipos Valéria , Nagy Attila , Harsha Nouh , Kőrösi László , Papp Magor , Ádány Róza , Varga Orsolya , Sándor János
Published: August 2019

The performance of general practitioners (GPs) is frequently assessed without considering the factors causing variability among general medical practices (GMPs). Our cross-sectional national-based study was performed in Hungary to evaluate the influence of GMP characteristics on performance indicators. The relationship between patient’s characteristics (age, gender, education) and GMP-specific parameters (practice size, vacancy of GP’s position, settlement type, and county of GMP) and the quality of care was assessed by multilevel logistic regression models. The variations attributable to physicians were small (from 0.77% to 17.95%). The education of patients was associated with 10 performance indicators. Practicing in an urban settlement mostly increased the quality of care for hypertension and diabetes care related performance indicators, while the county was identified as one of the major determinants of variability among GPs’ performance. Only a few indicators were affected by the vacancy and practice size. Thus, the observed variability in performance between GPs partially arose from demographic characteristics and education of patients, settlement type, and regional location of GMPs. Considering the real effect of these factors in evaluation would reflect better the personal performance of GPs.
Kinematic Analysis of Mae-Geri Kicks in Beginner and Advanced Kyokushin Karate Athletes
Authors: Błaszczyszyn Monika , Szczęsna Agnieszka , Pawlyta Magdalena , Marszałek Maciej , Karczmit Dariusz
Published: August 2019

Background: Each of the techniques used in sport is a complex technique requiring a combination of neuromuscular conduction, motor anticipation, and extremely developed proprioception. This is especially the case in martial arts when we deal with a kick or a blow to a specific target. Methods: The main purpose of this study was to determine the kinematic differences in the tested movement pattern among athletes with different levels of advancement in the conditions of kicking: in the air, at a target (a shield), and in direct contact with a competitor. Comparative analysis was performed among 26 players: 13 advanced (group G1) and 13 beginners (group G2). Kinematic data was recorded using an optical motion capture system. The examination consisted of performing three tests of mae-geri kick in sequences of three kicks in three different conditions (without a target, with a static target, and with an opponent). The examination was performed with the back leg and only the moment of kick was analyzed. Results: The most significant differences were observed in the movement of head, torso, hip, knee, and ankle segments, especially during a kick at a shield. Based on the conducted analysis, we can assume that karate training changes the strategy of neuromuscular control, promoting improvement of mobility pattern efficiency. Conclusion: Acquiring this type of knowledge can lead to better results, elimination of errors in training, especially in the initial period of training, and the prevention of possible injuries that occur during exercise or competition.
Measurement and Function of the Control Dimension in Parenting Styles: A Systematic Review
Authors: González-Cámara Marta , Osorio Alfonso , Reparaz Charo
Published: August 2019

Recent studies have shown different results in identifying which parenting style is the most beneficial for children, which has encouraged certain authors to wonder whether parental control is still needed for optimal parenting. As such investigations have been conducted with different measuring instruments, it is necessary to check whether the use of different instruments leads to different results. In order to figure this out, a systematic review of the recent literature (Web of Science and Scopus, 2000–2017) was carried out. This review found that, using certain instruments, parental control is associated with better outcomes in children, while using certain others, control is associated with worse outcomes. The difference seems to be in the way of measuring parental control.
Research on Relationships between Sexual Identity, Adverse Childhood Experiences and Non-Suicidal Self-Injury among Rural High School Students in Less Developed Areas of China
Authors: Li Xuyang , Zheng Huilie , Tucker Winter , Xu Wenyan , Wen Xiaotong , Lin Yixiang , Jia Zhihui , Yuan Zhaokang , Yang Wei
Published: August 2019

Purpose: The objective of this study was to examine the influence of sexual identity and adverse childhood experiences (ACEs) on non-suicidal self-injury (NSSI) among rural high school students in less developed areas of China. Methods: Behavior risk factors data collected from 1810 students from a high school in Jiangxi province, China. Five measures of childhood abuse and household dysfunction were summarized, and ACE was divided into 0, 1, 2, 3–5 ACEs. Logistic regression analysis was used to explore the influence of sexual identity, adverse childhood experiences, and their interaction with non-suicidal self-injury. Results: Compared with heterosexual students, high school students who identify as lesbian, gay, or bisexual (LGB) have a higher tendency of non-suicidal self-injury (AOR = 3.250, 95% CI = 1.69–6.28, p < 0.01). There was also a graded relationship between cumulative ACEs exposure and non-suicidal self-injury behaviors (AOR = 1.627, 95% CI = 1.02–2.60, p < 0.05). Odds for NSSI are higher among students with both experienced ACEs and identified as LGB (AOR = 2.821, 95% CI = 1.51–5.29, p < 0.05). Conclusions: Non-suicidal self-injury is associated with ACEs exposure and with those who identify as LGB, and the NSSI odds are greater when students identify as LGB and have experienced ACEs. More interventions to reduce non-suicidal self-injury should focus on LGB and ACEs and more attention needs to be paid to those who identify as LGB and have been exposed to ACEs.
Exploring Spatiotemporal Pattern of Grassland Cover in Western China from 1661 to 1996
Authors: Yang Fan , He Fanneng , Li Shicheng , Li Meijiao
Published: August 2019

Historical grassland cover change is vital for global and regional environmental change modeling; however, in China, estimates of this are rare, and therefore, we propose a method to reconstruct grassland cover over the past 300 years. By synthesizing remote sensing-derived Chinese land use and land cover change (LULCC) data (1980–2015) and potential natural vegetation data simulated by the relationship between vegetation and environment, we first determined the potential extent of natural grassland vegetation (PENG) in the absence of human activities. Then we reconstructed grassland cover across western China between 1661 and 1996 at 10 km resolution by overlaying the Chinese historical cropland dataset (CHCD) over the PENG. As this land cover type has been significantly influenced by anthropogenic factors, the data show that the proportion of grassland in western China continuously decreased from 304.84 × 106 ha in 1661 to 277.69 × 106 ha in 1996. This reduction can be divided into four phases, comprising a rapid decrease between 1661 and 1724, a slow decrease between 1724 and 1873, a sharp decrease between 1873 and 1980, and a gradual increase since 1980. These reductions correspond to annual loss rates of 7.32 × 104 ha, 2.90 × 104 ha, 17.04 × 104 ha, and −2.37 × 104 ha, respectively. The data reconstructed here show that the decrease in grassland area between 1661 and 1724 was mainly limited to the Gan-Ning region (Gansu and Ningxia) and was driven by the early agricultural development policies of the Qing Dynasty. Grassland was extensively cultivated in northeastern China (Heilongjiang, Jilin, and Liaoning) and in the Xinjiang region between 1724 and 1980, a process which resulted from an exponential increase in immigrants to these provinces. The reconstruction results enable provide crucial data that can be used for modeling long-term climate change and carbon emissions.
Dissecting the Proton Transport Pathway in Oral Squamous Cell Carcinoma: State of the Art and Theranostics Implications
Authors: Lorenzo-Pouso Alejandro I. , Pérez-Sayáns Mario , Rodríguez-Zorrilla Samuel , Chamorro-Petronacci Cintia , García-García Abel
Published: August 2019

Cancer cells overexpress proton exchangers at the plasma membrane in order acidify the extracellular matrix and maintain the optimal pH for sustaining cancer growth. Among the families of proton exchangers implicated in carcinogenesis, carbonic anhydrases (CAs), monocarboxylate transporters (MCTs), Na+/H+ exchangers (NHEs), sodium bicarbonate cotransporters (NBCs), and vacuolar ATPases (V-ATPases) are highlighted. Considerable research has been carried out into the utility of the understanding of these machineries in the diagnosis and prognosis of several solid tumors. In addition, as therapeutic targets, the interference of their functions has contributed to the discovery or optimization of cancer therapies. According to recent reports, the study of these mechanisms seems promising in the particular case of oral squamous cell carcinoma (OSCC). In the present review, the latest advances in these fields are summarized, in particular, the usefulness of proton exchangers as potential prognostic biomarkers and therapeutic targets in OSCC.