bluuebunny/crossref_metadata_2025 huggingface dataset:
Fresh Vegetables and Irrigation Water Microbial Quality in One Village and Two Periurban Farms in the Centre Region of Cameroon
Authors: Dalambert MINKA Joseph , Desoeuvres FOGANG FOKO , Yolande MOBOU Estelle , Sylvain Leroy SADO KAMDEM
Published: March 2024

The present study investigated the seasonal variation of microbial quality of irrigation water and vegetables produced at Nkolondom, Ebogo1 and Meyo farms in the Centre region of Cameroon. The physicochemical analysis of irrigation water was also studied. A total of 81 fresh horticultural products were harvested in the three farms and 27 water samples collected. For microbial quality, total aerobic mesophilic bacteria, total coliforms, E.coli and Vibrio spp were researched. Parameters such as pH, temperature, electrical conductivity, turbidity and total dissolved solids were measured at the water sampling sites. Data collected were analyzed using Statgraphics version 7.1 software. Results showed that total aerobic mesophilic bacteria had the highest count (9.78 log cfu/g) followed by total coliforms (7.5 log cfu/g), while faecal coliforms and Vibrio were the least represented. The maximal number of aerobic mesophilic bacteria was counted in parsley during the dry season (9.78 log cfu/g). The microbiological quality of irrigation water and vegetables was unacceptable, exceeding the standards accepted by WHO and International Commission on Microbiology Standards for Foods limits for safe consumption. These results indicate that the microbial hazard of these vegetables is alarmingly high and that consumers should be aware to take correct actions while consuming them.
PENGEMBANGAN BEBE ANAK DENGAN SUMBER IDE HEWAN KELINCI UNTUK ANAK USIA 5 TAHUN
Authors: Safaamalia  , Sugiyem Sugiyem
Published: March 2024

Penelitian ini mengembangkan bebe anak dengan menerapkan sumber ide hewan kelinci. Jenis penelitian yang digunakan adalah penelitian pengembangan (Research and Development) dengan model pengembangan 4D yang terdiri dari 4 tahap, yaitu : definisi (definition), desain (design), pengembangan (development), dan penerapan (disseminate). Metode pengumpulan data dalam penelitian ini dilakukan dengan penilaian uji publik bebe anak dengan sumber ide hewan kelinci. Hasil pengembangan busana bebe anak, yaitu busana bebe anak dengan siluet longtorso, kerah rebah yang di variasikan dengan telinga kerinci yang motifnya dibordir dengan siluet hewan kelinci. Hasil produk busana bebe anak ini memiliki kualifikasi sangat baik pada uji publik.
FACTORS DRIVING THE USE OF SOCIAL MEDIA IN BUYING FASHION READY TO WEAR
Authors: Resi Sepsilia Elvera  , Jerusalem Mohammad Adam , Himmah Laila Nurul , Mahanani Chytra , Nurlita Asri Andarini
Published: March 2024

Penelitian ini bertujuan untuk melihat Faktor pendorong penggunaan media sosial dalam membeli busana Ready To Wear. Populasi penelitian adalah mahasiswa Tata Busana Universitas Negeri Yogyakarta yang membelipakaian Ready To wear. Sampel diambil dari partisipan yang membeli busana Ready To Wear melalui media sosial. Data diambil menggunakan kuesioner dan observasi. Data yang terkumpul dianalisis secara deskriptif kuantitatif menggunakan pendekatan Exploratory Factor Analysis (EFA).Hasil penelitian menunjukan bahwa tingkat penggunaan media sosial sosial oleh mahasiswa menunjukan 3 faktor, dengan hasil cumulative sebesar 76.201. Artinya variabel penggunaan media social memiliki tingkatan yang cukup signifikan didalam pembelian busana ready to wear factor tersebut sebesar 76.20%. Pada variabel Minat Beli Busana Ready To Wear memiliki tingkatan yang cukup signifikan didalam pembelian busana ready to wear factor tersebut sebesar 76.20%
Penilaian E-modul Menggambar Ilustrasi Desain Gaya Harajuku
Authors: Siahaan Maria Angelina Arimbi , Eneng Lutfia Zahra  , Melly Prabawati
Published: March 2024

ABSTRAK

Penelitian ini bertujuan untuk mengetahui hasil penilaian e-modul Menggambar Ilustrasi Desain Gaya Harajuku dan menghasilkan e-modul Menggambar Ilustrasi Desain Gaya Harajuku. Metode penelitian yang digunakan dalam penelitian ini adalah metode kuantitatif deskriptif dengan pendekatan pre-eksperimental one-shot case study. Teknik pengumpulan data menggunakan instrumen tertutup-terbuka, yang diberikan kepada panelis ahli dengan menggunakan indikator berdasarkan aspek karakteristik modul yang baik dan berdasarkan aspek elemen mutu modul. Hasil penelitian ini menunjukkan bahwa penilaian berdasarkan aspek karakteristik modul yang baik memperoleh persentase penilaian sebesar 90,07%, sedangkan penilaian berdasarkan aspek elemen mutu modul memperoleh persentase penilaian sebesar 93,01%. Maka secara keseluruhan penilaian e-modul Menggambar Ilustrasi Desain Gaya Harajuku memperoleh persentase penilaian sebesar 91,54% dan berada pada kategori “Sangat Baik” sehingga dapat digunakan dalam proses pembelajaran.

Kata kunci : E-modul, Menggambar, Ilustrasi Desain, Gaya Harajuku
Pengaruh E-book Fashion Product Portfolio Terhadap Motivasi Belajar Mahasiswa
Authors: Andriani Siska , Arrsyi Esty Nurbaity , Sesnawati Yeni
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh e-book Fashion Product Portfolio terhadap motivasi belajar mahasiswa. Penelitian ini menggunakan metode eksperimen dengan pendekatan kuantitatif, desain penelitian pre-experiment tipe intact group comparison. Populasi dalam penelitian ini adalah mahasiswa Program Studi Desain Mode yang sedang mengambil mata kuliah Portofolio tahun ajaran 2023/2024 yang berjumlah 43 mahasiswa. Teknik pengumpulan data dilakukan dengan menggunakan kuesioner. Uji validitas yang digunakan adalah uji validitas konstruk. Teknik analisis yang digunakan adalah uji chi square. Teori yang digunakan adalah teori motivasi belajar oleh Frederick J. McDonald. Hasil penelitian ini menunjukkan terdapat pengaruh e-book Fashion Product Portfolio terhadap motivasi belajar mahasiswa. Hal ini dikarenakan e-book Fashion Product Portfolio merupakan buku elektronik berisi sistematika format portofolio mengenai pembuatan produk busana mulai dari konsep desain sampai dengan realisasi produk yang dapat dibaca dan digunakan kapan saja dan dimana saja menggunakan perangkat elektronik sehingga memudahkan mahasiswa untuk mengerjakan tugas maupun belajar secara mandiri. Keunggulan ini terbukti dapat meningkatkan motivasi belajar, terutama pada aspek indikator “lebih senang mengerjakan tugas secara mandiri” yang memperoleh persentase tertinggi.

Kata Kunci: motivasi belajar, e-book, portofolio.
Pulau Sebira Dalam Karya Batik Dengan Pewarna Alami Kayu Bakau
Authors: Hazmi Fariz Al , Kurnia Panji
Published: March 2024

Pulau Sebira merupakan salah satu pulau yang terletak di bagian paling utara Kepulauan Seribu Provinsi DKI Jakarta memiliki banyak keindahan alam yang dapat menjadi inspirasi dalam sebuah karya seni. Penelitian ini bertujuan untuk mengimplementasikan objek visual yang menjadi ciri khas lingkungan Pulau Sebira ke dalam sebuah motif batik dengan melakukan eksplorasi stilasi dan deformasi bentuk sehingga terbentuknya Batik Sebiran. Selain itu, penelitian ini juga menggunakan Bakau Merah (Rhizopora stylosa) sebagai pewarna pada batik tulis. Metode penelitian ini menggunakan metode kualitatif dengan melakukan uji coba eksplorasi terhadap motif, zat pewarna alami, dan desain dalam merancang Batik Sebiran. Jenis riset penelitian dan penciptaan ini menggunakan Research-led Practic, dimana dalam penelitian dan penciptaan karya batik Sebiran ini sebelunya dilakukan penelitian terlebih dahulu untuk mendapatkan hasil dari eksplorasi konsep yang kemudian hasil penelitian tersebut diimplementasikan ke dalam sebuah karya. Hasil yang diperoleh yaitu batik sebiran dengan lima desain yang berbeda dengan motif yang terinspirasi dari lingkungan Pulau Sebiran. Setiap desain memberikan filosofi dari berbagai motif yang tersusun menjadi karya batik. Lingkungan Pulau Sebira yang unik menjadi sebuah motif dalam karya batik tulis dengan memvisualisasikan lingkungan yang menjadi ciri khas pulau Sebira seperti Penyu sisik, Mercusuar peninggalan masa penjajahan belanda, pohon pidada, barongko yaitu makanan khas suku Bugis, Perahu dan ikan selar.
Makna Sahabatku Dalam Karya Seni Lukis
Authors: Anjani Chika Destry , Mudjiati
Published: March 2024

Melukis makna suatu persahabatan  merupakan kegiatan untuk mengekspresikan ide, imajinasi, dan emosi perupa yang akan memunculkan keindahan yang menggambarkan siapa sosok sahabat perupa. Tujuan penelitian ini adalah meningkatkan kemampuan perupa dalam pembuatan karya dan dapat mengemukakan ide, gagasan tentang makna persahabatan dalam karya seni lukis. Mengembangkan unsur rupa pada karya seni lukis dan mengasah kemampuan dalam mengimajinasikan bentuk-bentuk karakter. Menjadikan karya perupa sebagai pengingat dalam suatu persahabatan. Penelitian yang dilakukan perupa menggunakan metodelogi narative research dan Focus Group Discussion. Teknik yang digunakan adalah teknik plakat, pada teknik ini cat disapukan secara merata dan tebal. Melalui proses analisis konseptual, visual dan operasional terpilih dua karya. Karya terpilih 1 tentang bersenang-senang bersama dan karya terpilih 2 tentang terjadinya perpisahaan. Kesimpulan dari penulisan ini yaitu, meningkatkan kemampuan, keunikan perupa pada pembuatan karya, terampil dalam mengemukakan ide dan gagasan,  mengembangkan unsur rupa, teknik, serta bahan pada karya seni lukis,  mengasah kemampuan dalam mengimajinasikan bentuk-bentuk karakter pada makna persahabatan dalam karya seni lukis. Menjadikan kenangan bagi setiap orang yang bersahabat dengan membuat karya seperti perupa.
Picture Book Legenda Ki Rangga Gading Sebagai Media Pembelajaran Anak
Authors: Mauliani Aysha Davina , Mudjiati  , Kherid Zaitun Y.A
Published: March 2024

Seiring dengan perkembangan zaman cerita rakyat lisan luntur, menyebabkan banyak anak-anak yang tidak mengenal hal tersebut. Maka dari itu, perupa mengambil Skripsi Penciptaan Karya Seni Rupa dengan judul “Picture Book Cerita Legenda Jawa Barat Sebagai Media Pembelajaran Anak (Edisi: Ki Rangga Gading)”. Bertujuan mengangkat cerita legenda dari daerah Tasikmalaya, Jawa Barat kepada masyarakat luas, membuat picture book yang inovatif dan interaktif. Penelitian ini menggunakan metode kualitatif. Data dikumpulkan dengan cara dokumentasi, observasi, dan juga kuisioner. Kemudian hasil data tersebut dianalisis. Kesimpulan hasil penelitian berdasarkan analisis karya, kekuatan karya perupa buat ada di gaya ilustrasi dengan teknik digital painting, menggunakan warna menarik, dengan memperlihatkan ekspresi tokoh, memperlihatkan ciri khas karakteristik budaya Sunda.  Menggunakan teknik pop-up page. Teknik tersebut didominasi oleh ilustrasi atau gambar dengan sedikit teks cerita dengan tampilan visual yang lebih berdimensi membuat lebih nyata dengan kejutan yang diberikan setiap halamannya, biasa disebut “buku anak”. Sehingga mampu menarik minat baca anak dan media belajar bagi anak, untuk mengenal suku dan budaya Indonesia khususnya Jawa Barat.
Rafflesia Indonesia Sebagai Motif Tekstil Printing Tas Fashion Wanita
Authors: Pohan Irna Fhitramadhani , Candrasari MC. Wara , Kherid Zaitun Y.A
Published: March 2024

Tujuan penciptaan karya adalah untuk mengimplementasikan Rafflesia Indonesia sebagai motif dengan teknik digital printing dalam produk tas fashion wanita. Metode penelitian ini menggunakan metode kualitatif deskriptif (studi literatur; penjelajahan grant tour question;). Pada penjelajahan grant tour question, melakukan eksplorasi terhadap objek yang dijadikan sebagai acuan dalam penciptaan motif desain tekstil pada Rafflesia Indonesia, untuk selanjutnya dilakukan proses cetak digital printing. Pembuatan produk tas fashion wanita dilakukan melalui eksplorasi desain secara digital dan manual. Proses ini perlu dilakukan untuk menghasilkan sample produk dan mengetahui kinerja fungsi tas. Hasil yang diperoleh yaitu 5 tas fashion wanita yang diciptakan dengan konsep multifungsi gaya; berbahan perpaduan kulit produk hewan sapi dan kain polyester sesuai spesifikasi pengguna; menyesuaikan tren warna dan tas fashion 2020. Sekaligus sebagai pengenalan dan apresiasi Rafflesia Indonesia melalui motif yang ditampilkan.
Mitos Maung Putih Dalam Karya Lukis Modern
Authors: Fauzih Vebriyan Tri , Pahala Agam Akbar
Published: March 2024

Penciptaan ini bertujuan untuk penyampaian informasi mengenai pengaruh mitos Maung putih dalam kaitannya terhadap pelestarian ekologi serta korelasinya dalam menjaga stabilitas alam yang divisualisasikan dalam bentuk karya lukis. Melemahnya mitos sebagai kontrol perilaku masyarakat membuat banyak masyarakat menjadi sembarangan dalam menggunakan dan mengeksploitasi sumber daya alam yang berakibat ekologi alam terganggu. Penciptaan ini berangkat dari faktor internal tentang cerita arketipe bersama almarhum ayah yang kemudian mengacu dari aspek konseptual, aspek visual dan aspek operasional serta beberapa landasan kerangka teori dalam penciptaan dengan prinsip estetika seni modern. Penciptaan ini menggunakan metode kualitatif dengan pendekatan Artistic Research, di mana penelitian dan praktik penciptaan karya dilakukan secara bersamaan. Terdiri atas desain metode penciptaan, teknik dan instrumen pengumpulan data, dan teknik penyajian dan analisis data. Penciptaan karya ini memvisualisasikan kehadiran mitos maung putih dalam penjagaan ekologi alam dengan menggunakan interes seni pragmatis, interes bentuk semi figuratif, dan prinsip estetika modern. Karya divisualisasikan dalam bentuk karya lukis. Alat dan bahan utama yang digunakan adalah cat akrilik dan cat semprot di atas multipleks dengan menggunakan teknik blending. Penciptaan karya ini diharapkan dapat dijadikan sebagai himbauan kepada masyarakat untuk turut peduli serta selalu menjaga dan menghormati budaya adat istiadat dalam melestarikan ekologi alam.
Fatores de Risco Associados ao Desenvolvimento do Câncer de Próstata: uma Revisão da Literatura Brasileira
Authors: Silva Iran Alves da , Messias Maria Clara Amorim , Weller Mathias
Published: March 2024

Objetivo: Analisar estudos sobre os fatores de risco associados com o desenvolvimento do câncer de próstata (CP) no Brasil. Material e Método: A busca de estudos originais dos tipos caso-controle, transversal e de coorte nos últimos 10 anos, ocorreu nas bases de dados, Google acadêmico, LILACS, Medline e SciELO. Utilizou os seguintes descritores: “Neoplasias da Próstata”; “Fatores de Risco” e “Brasil” e seus sinônimos. Ao realizar a busca foi encontrado um total de 3.454 estudos e destes foram incluídos 12 publicações que cumpriram os critérios à síntese dessa revisão. Resultados: Os artigos selecionados tiveram origem nas seguintes regiões do Brasil, região Nordeste apresentou seis estudos dos selecionados, três no Sudeste, dois no Sul e um no Centro-oeste. O tamanho amostral variou entre 23 e 662 participantes. Nos 12 artigos analisados identificou-se que a maioria dos trabalhos representou estudos descritivos (N= 09), comparando possíveis fatores de risco em grupos de pacientes baseando-se na identificação dos fatores de risco em estudos internacionais. Outros estudos do tipo caso- controle (N= 03) aplicaram métodos analíticos de estatística para identificar os fatores de risco. A história familiar, o tabagismo, o sedentarismo, a ancestralidade africana e o uso prolongado de medicamentos foram os fatores de risco mais frequentes identificados nos 12 estudos. Concluões: A maioria dos estudos brasileiros até hoje são descritivos e existem apenas poucos estudos do tipo caso-controle, sendo muito provável que existem mais fatores de risco e que eles podem variar em diferentes populações do país.
DISHARMONI PERATURAN KEPOLISIAN DENGAN PERATURAN KEJAKSAAN DALAM PELAKSANAAN KEADILAN RESTORATIF
Authors: Arif Fahmi , Kholif As Syafii Nur Hamida
Published: March 2024

Penelitian ini dilatarbelakangi adanya perbedaan penyelesaian perkara pidana pada beberapa kasus yang telah diselesaikan menggunakan keadilan restoratif. Hal tersebut timbul akibat adanya peraturan Kepolisian Nomor 8 Tahun 2021 dan Peraturan Kejaksaan Nomor 15 Tahun 2020 sebagai payung hukum masing-masing lembaga dalam melaksanakannya. Fokus rumusan masalah pada penelitian ini adalah bagaimana disharmoni antara Peraturan Kepolisian dan Peraturan Kejaksaan dalam pengaturan pelaksanaan keadilan restoratif. Metode penelitian yang digunakan adalah penelitian Yuridis Normatif dengan pendekatan perundang-undangan untuk memahami status dan kedudukan Kepolisian sebagai pelaksana Penyidikan dan Kejaksaan sebagai pelaksana Penuntutuan dalam Sistem Peradilan Pidana. Hasil dari penelitian ini menunjukkan bahwa 1) ditemukan perbedaan pasal yang terdapat pada Peraturan Kepolisisan dan Peraturan Kejaksaan yang mengatur mengenai syarat perkara pidana yang bisa diselesaikan dengan keadilan restorative Hasil Sinkronisasi tindak pidana yang bisa diselesaikan dengan keadilan restoratif hanyalah tindak pidana dengan ancaman pidana penjara tidak lebih dari 5 (lima) tahun serta nilai barang bukti atau kerugian yang timbul akibat adanya tindakan tersebut tidak lebih dari Rp. 2.500.000,00 (dua juta lima ratus ribu rupiah). Hal tersebut merupakan sinkronisasi dari sisi aturan pelaksanaan keadilan restoratif serta dari sisi kedudukan Kepolisian dalam Penyidikan dan kedudukan Kejaksaan dalam Penuntutuan pada Sistem Peradilan Pidana.
The initial experience of robot-assisted nephron-sparing surgery in patients with renal cell cancer
Authors: Komarov M. I. , Zhumabaev N. K. , Klimov A. V. , Arakelyan G. A. , Matveev A. V. , Khachaturyan A. V. , Zemskova V. Y. , Matveev V. B.
Published: March 2024

Purpose of the study: analysis of our experience in performing robotic-assisted nephron-sparing surgeries using the da robotic system. Material and Methods. The retrospective study included the first 37 consecutive patients who underwent robot-assisted partial nephrectomy from May 2020 to december 2022. Results. To assess the surgical outcomes in patients undergoing partial nephrectomy, three parameters associated with trifecta achievement were analyzed. The trifecta was assessed according to the standard criteria, whereas the quadfecta, which in addition to the trifecta included preservation of >90 % of the glomerular filtration rate (calculated according to Cockroft–Gault) in the postoperative period (3–7 days), did not assess the stage of chronic renal failure one year after surgery, thus probably demonstrating the high percentage of its achievement (54.1 %). A positive surgical margin was observed in 1 (2.7 %) patients. Warm ischemia time of more than 25 minutes was used in 8 patients (21.6 %). Complications in the postoperative period (Clavien–Dindo II and higher) were observed in 1 (2.7 %) patient. Trifecta and quadfecta rates were 78.4 % and 54.1 %, respectively. To analyze the surgeons’ experience, 37 renal cell cancer patients were divided into two subgroups with first 20 and subsequent robotic partial nephrectomies. There were no differences in gender, age and calculated RENAL value between 2 subgroups. depending on the surgeons’ experience, statistically significant differences in the duration of surgery (p=0.035) and blood loss during surgery (p=0.007) were found. Conclusion. Considering the extensive experience of surgeons in the field of laparoscopic surgery for tumors of the renal parenchyma, the outcomes of robotic partial nephrectomies performed in 37 patients seem to be satisfactory and successful. The accumulated experience of surgeons after 20 robotic-assisted nephron-sparing surgeries makes it possible to significantly reduce surgery time and blood loss. The technique of robotic-assisted partial nephrectomy requires further improvements.
The abscopal effect: mechanism of occurrence and prospects of using it in therapy of metastatic cancer
Authors: Khachaturyan A. V. , Bulychkin P. V.
Published: March 2024

The abscopal effect in oncology has been known for 70 years, but until recently its clinical significance was rather low. The development of immune response checkpoint inhibitors has led to an active study of this phenomenon. There is now evidence of improved survival among patients, in whom the abscopal effect has been documented, opening new perspectives for the treatment of cancers at different stages. This review presents data on the mechanisms of the abscopal effect, experimental and clinical data, current limitations and possible perspectives. The aim of the study was to investigate the current concept of the abscopal effect occurrence and to evaluate the prospects of using the abscopal effect in therapy of metastatic cancer. Material and Methods. We searched publications in Pubmed system from 2010 to 2023. Of 286 publications, 72 were used for writing the review. Results. In the era of widespread use of immune checkpoint inhibitors (ICIs) for cancer therapy, the abscopal effect appears to be an effective therapeutic approach with broad prospects of application in the treatment of patients with metastatic cancer. Conclusion. The incidence of the abscopal effect has increased with the advent of immune therapy, and the use of ICIs with radiation therapy (RT) has shown improved survival even in patients with advanced disease. More research is needed to establish standardized treatment protocols, including the optimal dose and timing of RT, as well as the efficacy and safety of combination therapy with different classes of ICIs. Further search for clinical and laboratory abscopal effect predictors, which could allow personalized treatment approaches, is required.
Multimodal therapy for metastatic colorectal cancer: a case of complete clinical and radiological response of liver metastases
Authors: Dobrodeev A. Yu. , Kostromitsky D. N. , Tarasova A. S. , Afanasyev S. G. , Babyshkina N. N. , Ponomaryeva A. A. , Larionova I. V. , Dronova T. A. , Azovsky D. I.
Published: March 2024

Background. Colorectal cancer is one of the most common cancers and the second leading cause of cancer-related deaths worldwide. Population-based studies have shown that 25–30 % of patients with colorectal cancer have synchronous liver metastases at the time of diagnosis. despite modern advances in oncology and surgery, only 25 % of patients with metastatic colorectal cancer (mCRC) are suitable for liver resection, which is the only curative treatment option for these patients. In recent years, the indications for curative treatment of mCRC have expanded. due to the introduction of new targeted drugs into clinical practice, the tumor response rate to preoperative therapy has increased, thus increasing surgical resection rate. Some patients experience a complete clinical response, which is defined as the complete disappearance of liver metastases. However, 30–70 % of patients develop recurrent metastases in the liver within the first year of follow-up, and currently, even in the presence of complete regression of metastases, it is recommended to perform resection of the initially affected hepatic segments. Case presentation. We describe a case of complete clinical and radiological response of liver metastases after chemotherapy in a patient with sigmoid colon cancer. Molecular genetic analysis revealed the wild type of the Kras, Nras and Braf genes. The patient received 3 courses of preoperative chemotherapy according to the FOLFOxIRI + Cetuximab regimen. Laparoscopic sigmoid colon resection with d3 lymph node dissection was followed by adjuvant chemotherapy with oxaliplatin and 5-fluorouracil (12 cycles). After 16 months of follow-up, no evidence of colon cancer recurrence and liver metastasis was found. Conclusion. Current targeted therapy has demonstrated efficacy in treating mCRC with synchronous liver metastases and makes it possible, in selected cases, to avoid the liver resection provided that a complete clinical and radiological response of the metastases is achieved.
A case of pathological complete regression in combined modality treatment of resectable Her2/neu-positive gastric cancer
Authors: Avgustinovich A. V. , Afanasyev S. G. , Spirina L. V. , Kaygorodova E. V. , Ermolenko R. V. , Samtsov E. N. , Frolova I. G. , Cheremisina O. V.
Published: March 2024

Background. Overexpression of Her2neu occurs in 15–20% of patients with gastric cancer and correlates with an unfavorable prognosis. Case report. We report a case of pathological complete regression of resectable gastric cancer with Her2/neu overexpression. The patient received combined modality treatment including 8 cycles of neoadjuvant chemotherapy with mFLOT + trastuzumab followed by R0 resection. The addition of targeted therapy did not have a negative impact on the perioperative period. Histolohical examination of the surgical specimen revealed pathological complete response (Mandart TGR1). Currently, the patient has been followed-up for 27 months without signs of disease relapse. Conclusion. Total neoadjuvant chemotherapy with mFLОТ+ trastuzumab for operable gastric cancer with Her2/neu overexpression allows us to hope for improved long-term treatment outcomes.
Comparison of the effectiveness of intraoperative radiotherapy with external beam radiotherapy in patients with early breast cancer
Authors: Manikhas A. G. , Gor L. A. , Topuzov E. E. , Morozova A. V. , Kalinin I. V.
Published: March 2024

Background. Breast cancer is the most common cancer in women. The main treatment for breast cancer includes surgery, chemotherapy, radiation therapy, and hormone therapy. The role of radiation therapy in the management of breast cancer continues to evolve. Radiation therapy is currently being de-escalated to include the use of intraoperative radiotherapy (IORT) and adjuvant endocrine therapy. Purpose of the study: to compare the efficacy of IORT with that of external beam radiotherapy (EBRT) in the treatment of early breast cancer. Material and Methods. A retrospective study of 559 patients with early breast cancer was conducted in Clinical Oncology Center of Saint Petersburg. The main treatment group included 273 patients who underwent breast-conserving surgery with IORT and sentinel lymph node biopsy. The control group included 286 patients who underwent breast-conserving surgery with sentinel lymph node biopsy and EBRT. Results. For all patients, the median follow-up time was 59.1 months (interquartile range: 43.7 to 80.7), the minimum follow-up period was 0.6 months, and the maximum follow-up period was 110.4 months. Recurrence occurred in 18 (6.6 %) patients of the main group and in 8 (2.8 %) patients of the control group. A statistically significant association of biological subtype with survival outcomes was found (p=0.02). The hazard ratio for Luminal B of 1.88 (95 % CI 1.02, 3.46) corresponded to a 65 % chance of an earlier onset of a negative outcome. The hazard ratio for triple-negative breast cancer of 3.01 (95 % CI 1.53, 5.95) corresponded to a 75 % chance of an earlier negative outcome. In the main treatment group, 11 (4 %) patients developed disease progression, and 2 of them died of multiple organ failure. In the control group, disease progression was observed in 18 (6.3 %) patients, 6 of whom died. However, the analysis of overall survival using the Kaplan–Meier curve showed a statistically non-significant log-rank p-value (0.73). The 3-year survival rates were 100 % (100 – 100) in the treatment group and 98.2 % (96.7 – 99.8) in the control group. The 5-yaer survival rates were 99.3 % (97.9 – 100) in the treatment group and 97.8 % (96.2 – 99.6) in the control group. These results showed advantage of IORT over EBRT. Conclusions. Intraoperative radiotherapy is a safe and effective alternative to external beam radiotherapy for early breast cancer.
Assessment of the safety and feasibility of neoadjuvant chemotherapy (2 cycles of FLOT chemotherapy + chemoradiotherapy) followed by surgery in the treatment of locally advanced gastric cancer
Authors: Mironova D. Yu. , Skoropad V. Yu. , Kolobaev I. V. , Ivanov S. A. , Kaprin A. D.
Published: March 2024

The aim of the study was to analyze of the safety and feasibility of neoadjuvant chemotherapy (2 cycles of FLOT chemotherapy + chemoradiotherapy) followed by surgery in the treatment of locally advanced gastric cancer. Material and Methods. The phase II clinical trial included 47 patients with histologically verified locally advanced gastric cancer (cT3/T4a-b: 26/21 and cN0/N1–3: 20/27) treated at the A.F. Tsyba MRRC from 2018 to 2021. Lesion location was: upper third in 19 patients (esophageal invasion in 9 patients), middle third in 13 patients, lower third in 14 patients, and entire stomach in 1 patient. The tumor grade was G3 in 23 patients, G2 in 13 patients and G1 in 7 patients. Signet ring cell carcinoma was revealed in 4 patients. The patients received 2 cycles of induction chemotherapy with FLOT regimen (85 mg/m2 oxaliplatin + 200 mg/m2 calcium folinate + 50 mg/m2 docetaxel on day 1 + 2600 mg/m2 fluorouracil as 24-hour infusion from day 1; every 2 weeks) followed by 3d-conformal external beam radiotherapy (46 Gy in daily fractions of 2 Gy) combined with chemotherapy with capecitabine and oxaliplatin). The patients then underwent follow-up examination to exclude disease progression and to plan surgery. Postoperative complications were analyzed using the Clavien-dindo classification. Results. Induction chemotherapy followed by concurrent chemoradiotherapy was well tolerated. Forty-five (95.7 %) patients underwent surgery, 97.7 % of them underwent radical surgery. Postoperative complications were observed in 11 (23.4 %) patients. Grade III and more severe complications were observed in 3 (6.4 %) patients. It should be noted that postoperative mortality rate was low, amounting to 2.2 % (1 patient). Conclusion. Induction FLOT polychemotherapy followed by concurrent chemoradiotherapy was shown to be safe, feasible, and tolerable. Moreover, this treatment regimen did not reduce the frequency of R0 surgeries and did not increase incidence and severity of postoperative complications.
Fast neutron therapy in Tomsk: 40-year experience in cancer treatmnet
Authors: Startseva Zh. A. , Gribova O. V. , Velikaya V. V. , Sukhikh E. S. , Lisin V. A. , Novikov V. A.
Published: March 2024

The purpose of the study was to evaluate the efficacy of neutron therapy (NT) for salivary gland cancer and recurrent breast cancer. Material and Methods. The study included 130 patients with salivary gland cancer and 125 patients with recurrent breast cancer. Fast neutron therapy using U-120 cyclotron was given to the patients of the study group. Patients of the control group received standard radiotherapy (external beam radiotherapy). Results. Among patients with salivary gland cancer, a recurrence rate was significantly lower in patients who received a postoperative course of NT compared to patients of the control group (21.1 vs 45 %, p<0.05). The five-year overall survival rates were 73.8 ± 9.5 % and 43.2 ± 9.4 % in the study group and the control group, respectively (p<0.05). The five-year disease-free survival rates were 65.6 ± 7.5 % and 34.8 ± 9.1 % in the study and control groups, respectively (p<0.05). In patients with recurrent breast cancer, a significant increase in the frequency of complete regression in the study group compared to the control group was observed (91.8 vs 51.3 %, p<0.05). Ten-year survival rates in patients with no evidence of re-recurrence were 77.4 ± 8.7 % and 44.7 ± 8.8 % in the study group and the control group, respectively (p<0.05). Conclusion. The study demonstrated efficacy of fast neutron therapy in patients with salivary gland cancer and recurrent breast cancer. Neutron therapy did not result in serious complications, improved survival of the patients and decreased the recurrence rate compared with standard radiotherapy.
Estrés oxidativo en espermatozoides epididimarios de alpaca criopreservados con diferentes concentraciones de plasma seminal
Authors: Jimenez-Carpio Jhoana Stefani , Ugarelli-Galarza Alejandra , Evangelista-Vargas Shirley Sujey
Published: March 2024

Objective. To assess the oxidative stress on alpaca epididimal sperm frozen with different concentration of seminal plasma. Materials and methods. 29 post mortem alpaca epididymis were used. Epididymal sperm were obteined thought cuts and suspended in a diluent based on skim milk, egg yolk and fructose and dimethylacetamine. Samples were separated into four aliquots which were supplied with seminal plasma (v/v) in concentrations of 0, 10, 25 and 50% respectively; then, sperm motility was assessed before freezing; then, motility was assessed before freezing with an automatic freezer machine. After thawing, mitochondrial membrane activity, sperm viability, lipid peroxidation and sperm apoptosis were assessed using flow cytometry with images. Results. Sperm exposed to 50% seminal plasma showed the lowest post-thaw motility (3.5±3.7%) and the highest percentages of apoptotic cells (71.43±20.6%). No significant differences were found in the rest of parameters. Conclusions. This study constitutes non-conclusive evidence that presence of seminal plasma does not affect viability, mitochondrial activity, or lipid peroxidation of alpaca epididymal sperm during cryopreservation processes; however, when it is absent or added up to 25% in the cryopreservation process, it may be possible to obtain better results in terms of sperm motility and sperm apoptosis.
Composición bioquímica y mineral de especies vegetales consumidas por cabras en pastoreo en tres temporadas del año
Authors: Salgado-Beltrán Víctor Abrahán , Murillo-Amador Bernardo , Nieto-Garibay Alejandra , Armenta-Quintana José Ángel , Aguilera-Marin Narciso , Ortega-Pérez Ricardo
Published: March 2024

Objetive. Determine and compare the biochemical and mineral composition of plant species consumed by grazing goats in three seasons of the year (drought, rain, and transition). Materials and methods. Sampling of the plant species that consume goats in each season of the year were made, during the time the goats feed on the rangeland, following them by the feeding paths and registering the species, the organs consumed, and the proportion of consumption This data were used to calculate a preference index, registering the frequency of consumption The three most consumed species by goats per season were selected. Results. The most consumed species in the drought season were Cyrtocarpa edulis, Pithecollobium confine, and Cercidium floridum. During the rainy season, the most consumed species were Forchhammeria watsonii, Tecoma stans, and Cercidium floridum. The most consumed species during rainy season were, Cyrtocarpa edulis, Indigofera suffruticosa, and Mimosa distachya. The protein content and ethereal extract were superior (p≤0.05) in the drought season. The content of Ca, Mg, Mn, K, P, and total-N were superior (p≤0.05) in the rainy season. Conclusions. The plant species associated with the rangeland in the study area, showed variation per season of the year in mineral and biochemical content, although are a source of minerals and nutrients for goats.
Bentonita como adsorbente de arsénico y plomo en el tracto digestivo de bovinos: estudio in vitro
Authors: Fuentes-de María Torres Marco Tulio , Ramírez-Bribiesca Jacinto Efrén , Castro-González Numa Pompilio , Crosby-Galván María Magdalena , Pinto-Ruiz René , Hernández-Sánchez David
Published: March 2024

Objective. To determine the recommended dose of bentonite as a chelator of arsenic (As) and lead (Pb) in the rumen, abomasal and duodenal environment by means of an in vitro system, considering the variables of ruminal fermentation and the adsorbent effect of As and Pb. Materials and Methods. Vials were prepared with 50 mL of anaerobic medium and 0.5 g of alfalfa as substrate. The culture media were added with 1.01 and 1.95 ppm of As and Pb, respectively. The treatments consisted of different levels of bentonite (B) added to the medium, B-0%, B-1.5%, B-3.0% and B-4.5%. The media were incubated for 24 h, and pH, volatile fatty acid (VFA) and N-NH3 production, in vitro DM digestibility (IVDMD) and chelating effect of bentonite were measured, simulating rumen, abomasum and duodenum conditions. A completely randomised design and orthogonal contrasts were used. Results. Bentonite did not modify the pH (p > 0.05) and the molar proportion of VFAs, but the total VFA concentration presented a negative linear effect with increasing bentonite levels. Likewise, the N-NH3 level decreased (p < 0.05) with increasing inclusion levels of bentonite. The IVDMD was reduced with B-3% and B-4.5% (52.36b and 49.74b%) in comparison to B-0% and B-1.5% (62.30a and 61.98a%). Treatments B-1.5% and B-4.5% improved (p < 0.05) As and Pb adsorption in the rumen, abomasal and duodenal environments. Conclusions. The recommended level of bentonite as chelator of As and Pb is 1.5%; doses of 4.5% affect IVDMD and, consequently, animal productivity.
Mobile Apps to Support Mental Health Response in Natural Disasters: Scoping Review
Authors: Ezeonu Nwamaka Alexandra , Hertelendy Attila J , Adu Medard Kofi , Kung Janice Y , Itanyi Ijeoma Uchenna , Dias Raquel da Luz , Agyapong Belinda , Hertelendy Petra , Ohanyido Francis , Agyapong Vincent Israel Opoku , Eboreime Ejemai
Published: March 2024

Background

Disasters are becoming more frequent due to the impact of extreme weather events attributed to climate change, causing loss of lives, property, and psychological trauma. Mental health response to disasters emphasizes prevention and mitigation, and mobile health (mHealth) apps have been used for mental health promotion and treatment. However, little is known about their use in the mental health components of disaster management.

Objective

This scoping review was conducted to explore the use of mobile phone apps for mental health responses to natural disasters and to identify gaps in the literature.

Methods

We identified relevant keywords and subject headings and conducted comprehensive searches in 6 electronic databases. Studies in which participants were exposed to a man-made disaster were included if the sample also included some participants exposed to a natural hazard. Only full-text studies published in English were included. The initial titles and abstracts of the unique papers were screened by 2 independent review authors. Full texts of the selected papers that met the inclusion criteria were reviewed by the 2 independent reviewers. Data were extracted from each selected full-text paper and synthesized using a narrative approach based on the outcome measures, duration, frequency of use of the mobile phone apps, and the outcomes. This scoping review was reported according to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews).

Results

Of the 1398 papers retrieved, 5 were included in this review. A total of 3 studies were conducted on participants exposed to psychological stress following a disaster while 2 were for disaster relief workers. The mobile phone apps for the interventions included Training for Life Skills, Sonoma Rises, Headspace, Psychological First Aid, and Substance Abuse and Mental Health Services Administration (SAMHSA) Behavioural Health Disaster Response Apps. The different studies assessed the effectiveness or efficacy of the mobile app, feasibility, acceptability, and characteristics of app use or predictors of use. Different measures were used to assess the effectiveness of the apps’ use as either the primary or secondary outcome.

Conclusions

A limited number of studies are exploring the use of mobile phone apps for mental health responses to disasters. The 5 studies included in this review showed promising results. Mobile apps have the potential to provide effective mental health support before, during, and after disasters. However, further research is needed to explore the potential of mobile phone apps in mental health responses to all hazards.
The Daily Experiences of Hispanic and Latinx Dementia Caregivers Study: Protocol for a Fully Remote Daily Diary Observational Cohort Study
Authors: Mildrum Chana Sofía , Álvarez Lorelí , Poe Abigail , Bibriescas Natashia , Wang Danny Hai , DiFiglia Stephanie , Azuero Andrés , Crowe Michael , Puga Frank
Published: March 2024

Background

The Hispanic and Latinx community is disproportionately affected by Alzheimer disease and related dementias (ADRDs). In the United States, approximately 8.5 million caregivers of individuals with ADRDs identify as Hispanic and Latinx people, and caregiving-related stress and burden place caregivers at elevated risk for poor mental health outcomes, as well as loneliness and social isolation. To date, there is limited knowledge about the daily stress experiences of Hispanic and Latinx caregivers. Given this knowledge gap, it is critical to examine how personal, cultural, and contextual factors influence daily stress, mental health, and resilience over time among Hispanic and Latinx ADRD caregivers.

Objective

The goal of this protocol report is to present the rationale, methodology, planned analytical strategy, progress completed to date, and implications of future findings for “Nuestros Días” (Spanish for “our days”), a fully remote daily diary (DD), observational cohort study examining the day-to-day experiences of Hispanic and Latinx ADRD caregivers.

Methods

The study will recruit a cohort of up to 500 Hispanic and Latinx caregivers of individuals living with ADRD. Participants will complete measures assessing contextual, individual-level, and cultural factors at 3 intervals (enrollment, 6 months, and 12 months). Each of the timepoints will be followed by 21 days of DD surveys to report on daily stress, stress moderators, and mental health variables.

Results

Data collection began in March 2023 and is projected to end in December 2026. As of March 2024, we have enrolled 60 caregivers in the Nuestros Días study, 78.9% (n=15) of whom are Spanish speakers. The current completion rate for DD surveys is 79.4%, averaging approximately 18 surveys out of 21 completed. We expect to enroll 10 to 15 participants per month moving forward to achieve our enrollment goal.

Conclusions

Results from this study will identify which Hispanic and Latinx ADRD caregivers, and under what circumstances, appear to be at the greatest risk of experiencing poor mental health outcomes over time. This study represents a critical step forward in providing key guidance to develop effective, culturally sensitive interventions to support the health and well-being of Hispanic and Latinx ADRD caregivers, a historically underrepresented and underserved population in aging and caregiving research.

International Registered Report Identifier (IRRID)

DERR1-10.2196/55216
Introducing JMIR Rehabilitation and Assistive Technologies: A Venue for Publishing Interdisciplinary Research on the Development, Implementation, and Evaluation of Health Innovations and Emerging Technologies in the Field of Rehabilitation
Authors: Munce Sarah EP
Published: March 2024

Rehabilitation supports the affected individual and their caregivers in managing the health condition and its associated symptoms, altering the environment to accommodate needs, adapting tasks for safe and independent performance, facilitating self-management, and using assistive devices and technologies. JMIR Rehabilitation and Assistive Technologies focuses on pragmatic yet rigorous and impactful science that reports on the development, implementation, and evaluation of health innovations and interventions as well as emerging technologies in the field of rehabilitation.
Responsabilidad social empresarial, imagen y reputación de la empresa petrolera venezolana
Authors: Briceño Peña Antonio Nicolas , Flores Gutiérrez José Ovidio , Flores Márquez Sandra Lizbeth
Published: March 2024

La explotación petrolera genera importantes externalidades positivas, pero también implica fuertes impactos negativos. En este contexto, la responsabilidad social empresarial (RSE) es fundamental por su aporte al desarrollo sostenible (DS) y por las normativas que la rigen. Por ello, se planteó el objetivo de evaluar la RSE como predictor de la imagen (IMA) y la reputación (REP) de la compañía petrolífera del estado venezolano, mediante una investigación cuantitativa de alcance explicativo. Se aplicaron tres instrumentos tipo likert-7, adaptados de la literatura especializada, a una muestra de 400 trabajadores de la empresa en el año 2018, cuyos resultados fueron procesados con un modelo PLS-SEM. Los resultados mostraron que la RSE influye positivamente en la imagen que, a su vez, incide positivamente en la reputación empresarial. El principal aporte de esta investigación es ampliar el conocimiento en la relación entre la RSE la imagen y la reputación empresarial, en el contexto de la empresa pública petrolera.
Paridad de riesgo y diversificación en portafolios de inversión
Authors: Zapata Quimbayo Carlos Andres , García Gaona Robinson Alexander
Published: March 2024

El modelo de paridad de riesgo (PR) para la construcción de portafolios de inversión ofrece una alternativa valiosa y robusta frente al modelo media-varianza (MV) de Markowitz. En este trabajo se propone un marco de aplicación del enfoque de PR para dos portafolios diferentes: i) para el mercado de valores estadounidense y; ii) para un portafolio internacional con participación en los mercados desarrollados y emergentes en el que se incorporan México y Brasil. Para ello, introducimos una explicación de los fundamentos del enfoque de PR y de las estrategias de inversión basadas en PR. Luego, en la implementación del enfoque para los dos portafolios, se resaltan las limitaciones del modelo MV para el diseño de estrategias de inversión diversificadas, dado sus problemas de concentración y bajo desempeño. Además, se acompaña el ejercicio con métricas de concentración como el índice de Herfindahl-Hirschman (HHI) permitiendo confirmar la consistencia de los portafolios de PR al reducir su rebalanceo.
Agreement Between the Rapid Antigen Test for SARS-CoV-2 and the RT-qPCR Diagnostic Test
Authors: Barrios-Pérez Antonio , Cid-Oros Ivette , Becerril-Gutiérrez Carlos , Medina-Gómez Oswaldo S.
Published: March 2024

Objective: to assess the agreement between the rapid antigen testing (RATs) for SARS-CoV-2 and quantitative reverse transcription polymerase chain reaction (RT-qPCR). Methods: analytical CROSS-sectional study, conducted in three medical units from January 1, 2021, to June 30, 2022, in Mexico City, Mexico. Non-probabilistic sampling was performed using data from the Online Notification System for Epidemiological Surveillance. Data analysis was performed using frequency measures, Cohen’s kappa index, and maximum likelihood estimation. Results: Of 2173 participants with both diagnostic tests: 565 respiratory samples were concordant with a positive result (26.09% CI95% 24.25 - 27.99%), and 1229 with a negative result (56.55% CI95% 54.44 - 58.65%). The sensitivity of RAT VERSUS RT-qPCR was estimated to be 65.17% (95%CI 61.99 - 68.33%), while the specificity was 94.10% (95%CI 92.82 - 95.38%); a positive predictive value of 88.01% (95%CI 85.23 - 90.41%), and a negative predictive value of 80.27% (95%CI 78.19 - 82.24%). The Cohen’s kappa index was 0.62 (substantial agreement), and a calculated likelihood ratio of 40% at pre-test prevalence, a post-test probability of 88.3% was observed for a positive result with RAT in case of having COVID-19. Conclusion: The present study demonstrated substantial concordance between RAT and RT-qPCR, supporting the feasibility of using both tests. This provides clinicians with a valuable tool for informed decision making in the diagnostic context of COVID-19.