bluuebunny/crossref_metadata_2025 huggingface dataset:
Language Complexity in Historical Perspective: The Enduring Tropes of Natural Growth and Abnormal Contact
Authors: McElvenny James
Published: April 2021

Focusing on the work of John McWhorter and, to a lesser extent, Peter Trudgill, this paper critically examines some common themes in language complexity research from the perspective of intellectual history. The present-day conception that increase in language complexity is somehow a “natural” process which is disturbed under the “abnormal” circumstances of language contact is shown to be a recapitulation of essentially Romantic ideas that go back to the beginnings of disciplinary linguistics. A similar genealogy is demonstrated for the related notion that grammatical complexity is a kind of “ornament” on language, surplus to the needs of “basic communication.” The paper closes by examining the implications of these ideas for linguistic scholarship.
Seismogenic Structure Orientation and Stress Field of the Gargano Promontory (Southern Italy) From Microseismicity Analysis
Authors: Miccolis Simona , Filippucci Marilena , de Lorenzo Salvatore , Frepoli Alberto , Pierri Pierpaolo , Tallarico Andrea
Published: April 2021

Historical seismic catalogs report that the Gargano Promontory (southern Italy) was affected in the past by earthquakes with medium to high estimated magnitude. From the instrumental seismicity, it can be identified that the most energetic Apulian sequence occurred in 1995 with a main shock of MW = 5.2 followed by about 200 aftershocks with a maximum magnitude of 3.7. The most energetic earthquakes of the past are attributed to right-lateral strike-slip faults, while there is evidence that the present-day seismicity occur on thrust or thrust-strike faults. In this article, we show a detailed study on focal mechanisms and stress field obtained by micro-seismicity recorded from April 2013 until the present time in the Gargano Promontory and surrounding regions. Seismic waveforms are collected from the OTRIONS Seismic Network (OSN), from the Italian National Seismic Network (RSN), and integrated with data from the Italian National Accelerometric Network (RAN) in order to provide a robust dataset of earthquake localizations and focal mechanisms. The effect of uncertainties of the velocity model on fault plane solutions (FPS) has been also evaluated indicating the robustness of the results. The computed stress field indicates a deep compressive faulting with maximum horizontal compressive stress, SHmax, trending NW-SE. The seismicity pattern analysis indicates that the whole crust is seismically involved up to a depth of 40 km and indicates the presence of a low-angle seismogenic surface trending SW-NE and dipping SE-NW, similar to the Gargano–Dubrovnik lineament. Shallower events, along the eastern sector of the Mattinata Fault (MF), are W-E dextral strike-slip fault. Therefore, we hypothesized that the seismicity is locally facilitated by preexisting multidirectional fractures, confirmed by the heterogeneity of focal mechanisms, and explained by the different reactivation processes in opposite directions over the time, involving the Mattinata shear zone.
How Nanopores Influence Dry-Frame VP Pressure Sensitivity
Authors: Raj Rohit , Jaiswal Priyank , Wang Yulun , Grammer G. Michael , Weger Ralf J.
Published: April 2021

This paper investigates how nanopore size distribution influences dry-frame P-wave velocity (VP) pressure sensitivity. The study uses a set of twenty-three samples belonging to a single vertical core from the Mississippian-age Meramec formation of the mid-continent US. Individual samples had their facies interpreted, composition estimated, He-gas porosity (ΦHe) determined, and P-wave and S-wave transit times systematically measured for dry core-plugs in a 5–40 MPa loading and unloading cycle. Data from the unloading cycle were linearized in the log scale, and the slope of the best fitting line was considered as a representative of the dry-frame VP pressure sensitivity. A series of photomicrographs from each sample were analyzed using image processing methods to obtain the shape and size of the individual pores, which were mostly in the nanopore (10−6–10–9 m) scale. At the outset, the pore-shape distribution plots were used to identify and discard samples with excessive cracks and complex pores. When the remaining samples were compared, it was found that within the same facies and pore-shape distribution subgroups VP pressure sensitivity increased as the dominant pore-size became smaller. This was largely independent of ΦHe and composition. The paper postulates that at the nanopore scale in the Meramec formation, pores are mostly isolated, and an increase in the confining pressure increased the bulk moduli of the fluids in the isolated pores, which in turn increased the VP pressure sensitivity. The study proposes incorporating this effect quantitatively through a dual-fluid model where the part of the fluid in unconnected pores is considered compressible while the remaining is considered incompressible. Results start to explain the universal observation of why the presence of microporosity quintessentially enhances VP pressure sensitivity.
Market Costs and Financing Options for Grassland Carbon Sequestration: Empirical and Modelling Evidence From Qinghai, China
Authors: Wilkes Andreas , Wang Shiping , Lipper Leslie , Chang Xiaofeng
Published: April 2021

Asia’s grasslands provide livelihoods for some of the region’s poorest people. Widespread grassland degradation reduces the resilience and returns to herding livelihoods. Reversing degradation and conserving grasslands could not only improve herders’ situation, but also make a huge contribution to mitigating climate change by sequestering carbon in soils. However, the means for reaching each of these objectives are not necessarily the same. To realize this potentially huge dual livelihood/climate change mitigation outcome from improved grassland management, it is necessary to have detailed understanding of the processes involved in securing better livelihoods and sequestering carbon. Based on household surveys on the Tibetan Plateau and modeling results, this study estimates economic and market costs of grassland carbon sequestration, and analyzes the implications of household and carbon project cash flows for the design of financing options. Five scenarios are modeled involving cultivation of grass on severely degraded grassland (all scenarios) and reduced grazing intensity on less degraded land, which requires destocking by 29, 38, 47, 56, and 65% in each scenario). Modeling results suggest that economic benefits for herders are positive at low levels of destocking, and negative at high levels of destocking, but initial investments and opportunity costs are significant barriers to adoption for households in all destocking scenarios. Existing rural finance products are not suitable for herders to finance the necessary investments. Market costs–the cost at which transactions between herders and carbon project developers are feasible–depend on the scale of project implementation but are high compared to recent carbon market prices. Large initial investments increase project developers’ financing costs and risk, so co-financing of initial investments by government would be necessary. Therefore, public policies to support grassland carbon sequestration should consider the potential roles of a range of financial instruments.
Prioritizing Sex Recognition Over Learned Species Recognition: Hierarchical Mate Recognition in an Invasive Fish
Authors: Magellan Kit , García-Berthou Emili
Published: April 2021

Mate recognition is the process of identifying and assessing the appropriate species, sex or population of another individual for their suitability as a potential mate. Recognition may be innate or learned. Learning, the acquisition of knowledge or skills through experience, involves a relatively long-term change in behavioral responses. In this study we examined learned and innate mate recognition in invasive male mosquitofish, Gambusia holbrooki, interacting with female conspecifics and male and female native toothcarp, Aphanius iberus. Male mosquitofish directed no mating attempts at male toothcarp whereas numerous attempts were made toward female toothcarp. Male mosquitofish therefore differentiated between males and females, but initially did not distinguish between con- and heterospecific females. Neither the presence of a male toothcarp, nor the presence of a refugia affected the number of mating attempts received by females. However, by the second day males appeared to learn to more accurately direct their mating attempts, with larger female mosquitofish receiving the most attention, though smaller toothcarp females were still harassed. We propose that male mosquitofish, with a coercive mating system, are selected for persistence despite rejection by potential mates. In this scenario, the pool of potential mates may include heterospecifics whose avoidance of mating attempts may be ignored by male mosquitofish. It may thus be adaptive for male mosquitofish to prioritize sex recognition over species recognition: if one sex is recognized as a “non-mate” this will cut 50% from the pool of potential mates whereas recognition of a single species will remove many fewer potential mates from the pool. This innate sex recognition together with rapid learning of species identity may be a factor in the invasive success of mosquitofish.
DNA Methylation and Expression Profiles of Whole Blood in Parkinson’s Disease
Authors: Henderson Adrienne R. , Wang Qi , Meechoovet Bessie , Siniard Ashley L. , Naymik Marcus , De Both Matthew , Huentelman Matthew J. , Caselli Richard J. , Driver-Dunckley Erika , Dunckley Travis
Published: April 2021

Parkinson’s disease (PD) is the second most common age-related neurodegenerative disease. It is presently only accurately diagnosed at an advanced stage by a series of motor deficits, which are predated by a litany of non-motor symptoms manifesting over years or decades. Aberrant epigenetic modifications exist across a range of diseases and are non-invasively detectable in blood as potential markers of disease. We performed comparative analyses of the methylome and transcriptome in blood from PD patients and matched controls. Our aim was to characterize DNA methylation and gene expression patterns in whole blood from PD patients as a foundational step toward the future goal of identifying molecular markers that could predict, accurately diagnose, or track the progression of PD. We found that differentially expressed genes (DEGs) were involved in the processes of transcription and mitochondrial function and that PD methylation profiles were readily distinguishable from healthy controls, even in whole-blood DNA samples. Differentially methylated regions (DMRs) were functionally varied, including near transcription factor nuclear transcription factor Y subunit alpha (NFYA), receptor tyrosine kinase DDR1, RING finger ubiquitin ligase (RNF5), acetyltransferase AGPAT1, and vault RNA VTRNA2-1. Expression quantitative trait methylation sites were found at long non-coding RNA PAX8-AS1 and transcription regulator ZFP57 among others. Functional epigenetic modules were highlighted by IL18R1, PTPRC, and ITGB2. We identified patterns of altered disease-specific DNA methylation and associated gene expression in whole blood. Our combined analyses extended what we learned from the DEG or DMR results alone. These studies provide a foundation to support the characterization of larger sample cohorts, with the goal of building a thorough, accurate, and non-invasive molecular PD biomarker.
Experimenting With Online Governance
Authors: Tchernichovski Ofer , Frey Seth , Jacoby Nori , Conley Dalton
Published: April 2021

To solve the problems they face, online communities adopt comprehensive governance methods including committees, boards, juries, and even more complex institutional logics. Helping these kinds of communities succeed will require categorizing best practices and creating toolboxes that fit the needs of specific communities. Beyond such applied uses, there is also a potential for an institutional logic itself to evolve, taking advantage of feedback provided by the fast pace and large ecosystem of online communication. Here, we outline an experimental strategy aiming at guiding and facilitating such an evolution. We first review the advantages of studying collective action using recent technologies for efficiently orchestrating massive online experiments. Research in this vein includes attempts to understand how behavior spreads, how cooperation evolves, and how the wisdom of the crowd can be improved. We then present the potential usefulness of developing virtual-world experiments with governance for improving the utility of social feedback. Such experiments can be used for improving community rating systems and monitoring (dashboard) systems. Finally, we present a framework for constructing large-scale experiments entirely in virtual worlds, aimed at capturing the complexity of governance dynamics, to empirically test outcomes of manipulating institutional logic.
Barriers and Facilitators Associated With Vaccine Acceptance and Uptake Among Pregnant Women in High Income Countries: A Mini-Review
Authors: Qiu Xiao , Bailey Heather , Thorne Claire
Published: April 2021

Vaccination during pregnancy is a safe and effective intervention to protect women from potentially severe consequences of influenza and reduce risk of influenza and pertussis in their infants. However, coverage remains variable. In this mini-review we update findings from a 2015 systematic review to describe results from recent studies in high income countries on the uptake of influenza and pertussis vaccination in pregnancy, reasons for vaccine hesitancy and barriers to increasing uptake, from maternal and healthcare provider (HCP) perspectives. Studies reported highly variable uptake (from 0% to 78%). A main facilitator for uptake among pregnant women was receiving a recommendation from their HCP. However, studies showed that HCP awareness of guidelines did not consistently translate into them recommending vaccines to pregnant women. Safety concerns are a well-established barrier to uptake/coverage of maternal immunization; 7%-52% of unvaccinated women gave safety concerns as a reason but these were also present in vaccinated women. Knowledge/awareness gaps among pregnant women and lack of confidence among HCPs to discuss vaccination were both important barriers. Several studies indicated that midwives were more likely to express safety concerns than other HCPs, and less likely to recommend vaccination to pregnant women. Women who perceived the risk of infection to be low were less likely to accept vaccination in several studies, along with women with prior vaccine refusal. Findings highlight the importance of further research to explore context-specific barriers to vaccination in pregnancy, which may include lack of vaccine confidence among pregnant woman and HCPs, and policy and structural factors.
Association Between Respiratory Alkalosis and the Prognosis of COVID-19 Patients
Authors: Wu Chenfang , Wang Guyi , Zhang Quan , Yu Bo , Lv Jianlei , Zhang Siye , Wu Guobao , Wu Shangjie , Zhong Yanjun
Published: April 2021

Aim: The aim of the study was to describe the clinical characteristics of patients with or without respiratory alkalosis, and analyze the relationship of respiratory alkalosis and the outcome of adult coronavirus disease 2019 (COVID-19) patients.

Methods: Clinical and laboratory data of adult COVID-19 patients in a single center in China, were retrospectively collected and analyzed. The Kaplan-Meier (KM) curve and cox regression were adopted to analyze the association between respiratory alkalosis and prognosis of COVID-19 patients.

Results: Of 230 adult COVID-19 patients, 66 patients (28.7%) had respiratory alkalosis on admission. Of 66 patients, the median age was 53 years old (range, 21–84 years), and 43 (65.2%) were female. Compared with those without respiratory alkalosis, patients with respiratory alkalosis were significantly older (P = 0.002), had a higher proportion of female (P = 0.004), and showed higher ratios of underlying diseases including hypertension (P = 0.023) and cardiovascular disease (P = 0.028). Moreover, they demonstrated higher proportion of severe events (P = 0.001). Patients with respiratory alkalosis had a higher possibility of developing severe events compared with those without respiratory alkalosis (Log Rank P = 0.001). After adjusting for gender, age, and comorbidities, patients with respiratory alkalosis still showed significantly elevated risks of developing to severe cases (HR 2.445, 95% CI 1.307–4.571, P = 0.005) using cox regression analyses.

Conclusions: Respiratory alkalosis as a common acid—base disorder in COVID-19 patients, was associated with a higher risk of developing severe event.
Blood Oxygenation Level-Dependent Response to Multiple Grip Forces in Multiple Sclerosis: Going Beyond the Main Effect of Movement in Brodmann Area 4a and 4p
Authors: Alahmadi Adnan A. S. , Pardini Matteo , Samson Rebecca S. , D’Angelo Egidio , Friston Karl J. , Toosy Ahmed T. , Gandini Wheeler-Kingshott Claudia A. M.
Published: April 2021

This study highlights the importance of looking beyond the main effect of movement to study alterations in functional response in the presence of central nervous system pathologies such as multiple sclerosis (MS). Data show that MS selectively affects regional BOLD (blood oxygenation level dependent) responses to variable grip forces (GF). It is known that the anterior and posterior BA 4 areas (BA 4a and BA 4p) are anatomically and functionally distinct. It has also been shown in healthy volunteers that there are linear (first order, typical of BA 4a) and nonlinear (second to fourth order, typical of BA 4p) BOLD responses to different levels of GF applied during a dynamic motor paradigm. After modeling the BOLD response with a polynomial expansion of the applied GFs, the particular case of BA 4a and BA 4p were investigated in healthy volunteers (HV) and MS subjects. The main effect of movement (zeroth order) analysis showed that the BOLD signal is greater in MS compared with healthy volunteers within both BA 4 subregions. At higher order, BOLD-GF responses were similar in BA 4a but showed a marked alteration in BA 4p of MS subjects, with those with greatest disability showing the greatest deviations from the healthy response profile. Therefore, the different behaviors in HV and MS could only be uncovered through a polynomial analysis looking beyond the main effect of movement into the two BA 4 subregions. Future studies will investigate the source of this pathophysiology, combining the present fMRI paradigm with blood perfusion and nonlinear neuronal response analysis.
Glycolysis-Based Genes Are Potential Biomarkers in Thyroid Cancer
Authors: Xu Feng , Xu Huan , Li Zixiong , Huang Yuanyuan , Huang Xiaoling , Li Yangyi , Zheng Xiaohe , Chen Yongsong , Lin Ling
Published: April 2021

While increased glycolysis has been identified as a cancer marker and attracted much attention in thyroid cancer (THCA), the prognostic role of it remains to be further elucidated. Here we aimed to determine a specific glycolysis-associated risk model to predict THCA patients' survival. We also explored the interaction between this signature and tumor immune microenvironment and performed drug screening to identify specific drugs targeting the glycolysis-associated signature. Six genes (CHST6, POM121C, PPFIA4, STC1, TGFBI, and FBP2) comprised the specific model, which was an independent prognostic indicator in THCA patients determined by univariate, LASSO and multivariate Cox regression analyses. The receiver operating characteristic (ROC) curve analysis confirmed the excellent clinical performance of the prognostic signature. According to the specific gene signature, patients were categorized into high- and low-risk subgroups. The high-risk group was characterized by decreased immune score and elevated tumor purity, as well as worser survival prognosis compared to the low-risk group. We also validated the expression of these genes in clinical samples and in-vitro experiments. Lastly, we identified potential drugs targeting the glycolysis-associated signature. The derived glycolysis-related signature is an independent prognostic biomarker for THCA patients and might be used as an efficacy of biomarker for drug-sensitivity prediction.
Impact of Acute Kidney Injury on Critically Ill Children and Neonates
Authors: Leghrouz Bassil , Kaddourah Ahmad
Published: April 2021

Acute kidney injury (AKI) is a clinical syndrome that manifests as an abrupt impairment of kidney function. AKI is common in critically ill pediatric patients admitted to the pediatric intensive care units. AKI is a deleterious complication in critically ill children as it is associated with increased morbidity and mortality. This review provides an overview of the incidence, morbidity, and mortality of AKI in critically ill children in general and specific cohorts such as post-cardiac surgeries, sepsis, critically ill neonates, and post stem cell transplantation.
Mitochondrial Function as a Potential Tool for Assessing Function, Quality and Adulteration in Medicinal Herbal Teas
Authors: Woodley Steven B. , Mould Rhys R. , Sahuri-Arisoylu Meliz , Kalampouka Ifigeneia , Booker Anthony , Bell Jimmy D.
Published: April 2021

Quality control has been a significant issue in herbal medicine since herbs became widely used to heal. Modern technologies have improved the methods of evaluating the quality of medicinal herbs but the methods of adulterating them have also grown in sophistication. In this paper we undertook a comprehensive literature search to identify the key analytical techniques used in the quality control of herbal medicine, reviewing their uses and limitations. We also present a new tool, based on mitochondrial profiling, that can be used to measure medicinal herbal quality. Besides being fundamental to the energy metabolism required for most cellular activities, mitochondria play a direct role in cellular signalling, apoptosis, stress responses, inflammation, cancer, ageing, and neurological function, mirroring some of the most common reasons people take herbal medicines. A fingerprint of the specific mitochondrial effects of medicinal herbs can be documented in order to assess their potential efficacy, detect adulterations that modulate these effects and determine the relative potency of batches. Furthermore, through this method it will be possible to assess whole herbs or complex formulas thus avoiding the issues inherent in identifying active ingredients which may be complex or unknown. Thus, while current analytical methods focus on determining the chemical quality of herbal medicines, including adulteration and contamination, mitochondrial functional analysis offers a new way of determining the quality of plant derived products that is more closely linked to the biological activity of a product and its potential clinical effectiveness.
Molecular Regulation of the Melatonin Biosynthesis Pathway in Unipolar and Bipolar Depression
Authors: Dmitrzak-Weglarz Monika , Banach Ewa , Bilska Karolina , Narozna Beata , Szczepankiewicz Aleksandra , Reszka Edyta , Jablonska Ewa , Kapelski Paweł , Skibinska Maria , Pawlak Joanna
Published: April 2021

Melatonin is a neurohormone that maintains the circadian rhythms of the body. By regulating the secretion of other hormones and neurotransmitters, it acts as a pleiotropic modulator that affects, for example, reproductive, immune, cardiovascular, sleep, and wake systems and mood. Thus, synthetic melatonin has become an essential component in the treatment of depressive disorders. Although we know the pathway of melatonin action in the brain, we lack comprehensive cross-sectional studies on the periphery of depressed patients. This study aimed to comprehensively analyze the differences between healthy control subjects (n = 84) and unipolar and bipolar depression patients (n = 94), including an analysis of the melatonin pathway at the level of the genes and serum biomarkers. An innovative approach is a pilot study based on gene expression profiling carried out on clinical and cell culture models using agomelatine and melatonin. We confirmed the melatonin biosynthesis pathway's molecular regulation dysfunctions, with a specific pattern for unipolar and bipolar depression, at the AANAT gene, its polymorphisms (rs8150 and rs3760138), and examined the serum biomarkers (serotonin, AANAT, ASMT, and melatonin). The biological pathway analysis uncovered pathways and genes that were uniquely altered after agomelatine treatment in a clinical model and melatonin treatment in a cell culture model. In both models, we confirmed the immunomodulatory effect of melatonin agents in depression.
Abscisic Acid as an Emerging Modulator of the Responses of Plants to Low Oxygen Conditions
Authors: González-Guzmán Miguel , Gómez-Cadenas Aurelio , Arbona Vicent
Published: April 2021

Different environmental and developmental cues involve low oxygen conditions, particularly those associated to abiotic stress conditions. It is widely accepted that plant responses to low oxygen conditions are mainly regulated by ethylene (ET). However, interaction with other hormonal signaling pathways as gibberellins (GAs), auxin (IAA), or nitric oxide (NO) has been well-documented. In this network of interactions, abscisic acid (ABA) has always been present and regarded to as a negative regulator of the development of morphological adaptations to soil flooding: hyponastic growth, adventitious root emergence, or formation of secondary aerenchyma in different plant species. However, recent evidence points toward a positive role of this plant hormone on the modulation of plant responses to hypoxia and, more importantly, on the ability to recover during the post-hypoxic period. In this work, the involvement of ABA as an emerging regulator of plant responses to low oxygen conditions alone or in interaction with other hormones is reviewed and discussed.
Sound and Soundscape in Restorative Natural Environments: A Narrative Literature Review
Authors: Ratcliffe Eleanor
Published: April 2021

Acoustic experiences of nature represent a growing area in restorative environments research and are explored in this narrative literature review. First, the work surveyed indicates that nature is broadly characterized by the sounds of birdsong, wind, and water, and these sounds can enhance positive perceptions of natural environments presented through visual means. Second, isolated from other sensory modalities these sounds are often, although not always, positively affectively appraised and perceived as restorative. Third, after stress and/or fatigue nature sounds and soundscapes can lead to subjectively and objectively improved mood and cognitive performance, as well as reductions in arousal, although some inconsistencies in findings are observed. Fourth, theoretical frameworks of restorative environments would benefit from inclusion of acoustic environmental properties such as sound intensity or frequency. Fifth, findings regarding positive, learned semantic associations with nature have arisen as a result of recent work on sounds and restoration. This represents another important area of potential theoretical development for broader restorative environments research.
Study on the Experience of Public Health System Construction in China's COVID-19 Prevention
Authors: Zhang Pengfei
Published: April 2021

Background: China's experience in the process of COVID-19 prevention provides a reference for other countries in the world. This article studied the experience of public health system construction in China's COVID-19 prevention.

Methods: Based on literature review and theoretical analysis, this paper constructs a theoretical framework of national public health system construction in health crisis. Based on this theoretical framework, combined with the policies and measures formulated by the Chinese government in the process of COVID-19 prevention, this article evaluate the advantages and deficiencies of China's public health system construction in response to COVID-19.

Results: The Chinese government ensured the adequate supply of health resources, improved people's ability to pay medical expenses, and adopted advanced public health propaganda methods based on the Internet to help people grasp the basic information and development trend of COVID-19 in the process of COVID-19 prevention. At the same time, the utilization efficiency of health resources was low in China, people's ability to pay for medical expenses was unequal, and the disclosure of virus information in the early stage of the outbreak of COVID-19 is not timely.

Conclusions: Other countries can learn from the advantages of China's public health system construction and avoid China's deficiencies in the process of public health system construction, which will help them improve the efficiency of COVID-19 prevention.
“They Just Tell Me to Abstain:” Variable Access to and Uptake of Sexual and Reproductive Health Services Among Adolescents Living With HIV in Kenya
Authors: Lawrence Sarah , Moraa Hellen , Wilson Kate , Mutisya Immaculate , Neary Jillian , Kinuthia John , Itindi Janet , Nyaboe Edward , Muhenje Odylia , Chen Tai-Ho , Singa Benson , McGrath Christine J. , Ngugi Evelyn , Kohler Pamela , Roxby Alison C. , Katana Abraham , Ng'ang'a Lucy , John-Stewart Grace C. , Beima-Sofie Kristin
Published: April 2021

Background: To improve holistic care for adolescents living with HIV (ALHIV), including integration of sexual and reproductive health services (SRHS), the Kenya Ministry of Health implemented an adolescent package of care (APOC). To inform optimized SRH service delivery, we sought to understand the experiences with SRHS for ALHIV, their primary caregivers, and health care workers (HCWs) following APOC implementation.

Methods: We completed a mixed methods evaluation to characterize SRHS provided and personal experiences with access and uptake using surveys conducted with facility managers from 102 randomly selected large HIV treatment facilities throughout Kenya. Among a subset of 4 APOC-trained facilities in a high burden county, we conducted in-depth interviews (IDIs) with 40 ALHIV and 40 caregivers of ALHIV, and 4 focus group discussions (FGDs) with HCWs. Qualitative data was analyzed using thematic analysis. Facility survey data was analyzed using descriptive statistics.

Results: Of 102 surveyed facilities, only 56% reported training in APOC and 12% reported receiving additional adolescent-related SRHS training outside of APOC. Frequency of condom provision to ALHIV varied, with 65% of facilities providing condoms daily and 11% never providing condoms to ALHIV. Family planning (FP) was provided to ALHIV daily in 60% of facilities, whereas 14% of facilities reported not providing any FP services to ALHIV. Screening and treatment for STIs for adolescents were provided at all clinics, with 67% providing STI services daily. Three key themes emerged characterizing experiences with adolescent SRHS access and uptake: (1) HCWs were the preferred source for SRH information, (2) greater adolescent autonomy was a facilitator of SRH discussions with HCWs, and (3) ALHIV had variable access to and limited uptake of SRHS within APOC-trained health facilities. The primary SRHS reported available to ALHIV were abstinence and condom use education. There was variable access to FP, condoms, pregnancy and STI testing, and partner services. Adolescents reported limited utilization of SRHS beyond education.

Conclusions: Our results indicate a gap in SRHS offered within APOC trained facilities and highlight the importance of adolescent autonomy when providing SRHS and further HCW training to improve SRHS integration within HIV care for ALHIV.
Visually Induced Roll Circular Vection: Do Effects of Stimulation Velocity Differ for Supine and Upright Participants?
Authors: Wang Yixuan , Du Bo , Wei Yue , So Richard H. Y.
Published: April 2021

Visually induced circular vection (CV) has been the subject of a wide range of functional brain and behavioral research. Participants in MRI or PET studies on CV were mostly in a supine viewing position, while participants in behavioral studies on CV were mostly in an upright viewing position. This study examines the effects of viewing positions (upright and supine) on roll CV reported by 16 participants while watching random dots (92 × 60 degrees field-of-view) rotating at different angular velocities (2, 4, 8, 16, 32, 64 deg/s) for 30 s. Viewing positions affected roll CV durations differently depending on the stimulation velocities. At slower velocities (2, 4, and 8 deg/s), participants exhibited significantly longer roll CV sensations when they were sitting in an upright position as opposed to lying in a supine position. The onset of roll CV was also significantly earlier with participants in an upright position despite similar roll CV intensities in both viewing positions. Significant two-way interactions between effects of viewing positions and dot rotating velocities for some conditions were noted. Consistency between current findings and the hypothesis predicting a weaker roll CV in upright positions based upon perceived gravity by the otolith organs is discussed.
Trends in the Epidemiology of Leishmaniasis in the City of Barcelona (1996–2019)
Authors: Palma David , Mercuriali Lilas , Figuerola Jordi , Montalvo Tomás , Bueno-Marí Rubén , Millet Joan-Pau , Simón Pere , Masdeu Eva , Rius Cristina
Published: April 2021

Background: Leishmaniasis is a neglected zoonosis produced by 20 different flagellated parasites of the Leishmania genus, a protozoan transmitted to humans and other vertebrates by the bite of dipteran insects of the Phlebotominae subfamily. It is endemic in Mediterranean countries and the number of cases is expected to increase due to climate change and migration. Prioritizing public health interventions for prevention and control is essential. The objective was to characterize the epidemiology and temporal trends in the incidence of human leishmaniasis in the city of Barcelona, between the years 1996 and 2019.

Methods: A population-based, analytical observational study among residents in the city of Barcelona was conducted of all the cases of leishmaniasis reported between 1996 and 2019 to the Public Health Agency. The epidemiological survey contains clinical, diagnostic, and epidemiological data, including contact with suspicious mammals or insects. Annual incidence-rates were calculated by sex, age, and country of origin. Chi-square tests were used to assess association between studied risk factors, periods of time and type of leishmaniasis.

Results: During the study period a total of 177 cases of leishmaniasis were reported in Barcelona, being 74.6% (n = 132) of the total cases in Spanish born, although within the foreign-born population the incidence was higher. Median age was 34 years (IQR = 10–48) and 121 (66.8%) were male. The main type was cutaneous (46%) followed by visceral (35.1%). The cumulative incidence was 0.47 per 100,000 inhabitants, with the highest incidence found in 2017 (1.60 per 100,000 inhabitants). A higher incidence was observed in the 0–4-year-old group (1.73 per 100,000 inhabitants), but increased during the study period for all age groups. There was an increase of foreign origin cases, and a decrease in the number of cases associated to any immunosuppression.

Conclusion: In Barcelona, leishmaniasis incidence continues to be higher in people under 5 years of age, and 25–64 years old males, but it has also increased in population from foreign country of birth. There is an increase of the cases since 2016, probably due to the changes in the notification system, increasing the diagnosis of cutaneous leishmaniasis. Improvements in the current surveillance system are needed. Notification of the disease, vector, and reservoir control activities are also essential for the control of the disease.
Risk Stratification of Cholangiocarcinoma Patients Presenting with Jaundice: A Retrospective Analysis from a Tertiary Referral Center
Authors: Lleo Ana , Colapietro Francesca , Maisonneuve Patrick , Aloise Monia , Craviotto Vincenzo , Ceriani Roberto , Rimassa Lorenza , Badalamenti Salvatore , Donadon Matteo , Pedicini Vittorio , Repici Alessandro , Di Tommaso Luca , Voza Antonio , Torzilli Guido , Aghemo Alessio
Published: April 2021

Cholangiocarcinomas (CCAs) are a heterogeneous group of tumors that arise from the biliary tract. Jaundice is a common clinical presentation; however, the prognostic impact of this symptom is poorly understood, and current management recommendations lack solid evidence. We aim to assess the clinical outcomes and predictive factors of CCA patients presenting with jaundice in the Emergency Room (ER). We retrospectively analyzed all consecutive ER cases presenting with jaundice between January 2010 and December 2017. During the study period, 403,766 patients were admitted to the ER, 1217 (0.3%) presented with jaundice, and in 200 (0.049%), the diagnosis was CCA. CCA cases increased during the study period (p for trend 0.026). Most of them presented with advance disease (stage III 46.5%, stage IV 43.5%) and median survival was 4.5 months (95% CI 3.4–6.0). Factors associated with better survival were age, stage of disease, presence of jaundice at the moment of diagnosis, and lack of concomitant viral hepatitis. A nomogram was constructed that significantly predicts 1-month, 6-month, and 1-year survival after patients’ admission. In conclusion, the majority of CCA patients presenting with jaundice to the ER have advanced disease and poor prognosis. Risk stratification of these patients can allow tailored management.
Deep Learning Prediction of Metastasis in Locally Advanced Colon Cancer Using Binary Histologic Tumor Images
Authors: Schiele Stefan , Arndt Tim Tobias , Martin Benedikt , Miller Silvia , Bauer Svenja , Banner Bettina Monika , Brendel Eva-Maria , Schenkirsch Gerhard , Anthuber Matthias , Huss Ralf , Märkl Bruno , Müller Gernot
Published: April 2021

In this study, we developed the Binary ImaGe Colon Metastasis classifier (BIg-CoMet), a semi-guided approach for the stratification of colon cancer patients into two risk groups for the occurrence of distant metastasis, using an InceptionResNetV2-based deep learning model trained on binary images. We enrolled 291 colon cancer patients with pT3 and pT4 adenocarcinomas and converted one cytokeratin-stained representative tumor section per case into a binary image. Image augmentation and dropout layers were incorporated to avoid overfitting. In a validation collective (n = 128), BIg-CoMet was able to discriminate well between patients with and without metastasis (AUC: 0.842, 95% CI: 0.774–0.911). Further, the Kaplan–Meier curves of the metastasis-free survival showed a highly significant worse clinical course for the high-risk group (log-rank test: p < 0.001), and we demonstrated superiority over other established risk factors. A multivariable Cox regression analysis adjusted for confounders supported the use of risk groups as a prognostic factor for the occurrence of metastasis (hazard ratio (HR): 5.4, 95% CI: 2.5–11.7, p < 0.001). BIg-CoMet achieved good performance for both UICC subgroups, especially for UICC III (n = 53), with a positive predictive value of 80%. Our study demonstrates the ability to stratify colon cancer patients via a semi-guided process on images that primarily reflect tumor architecture.
Patient-Reported Outcomes of Regular Aerobic Exercise in Gastric Cancer
Authors: Lee Myung-Kyung , Oh Jihyun
Published: April 2021

The benefits of exercise for health-related quality of life (HRQOL) and depression in patients with gastrointestinal disease remain unclear, and studies on gastric cancer are scant. This study examines the association between the maintenance of regular aerobic exercise at a recommended level and depression and HRQOL in patients with gastric cancer during or after treatment. In this cross-sectional study, a face-to-face survey was used to collect data from 126 patients with primary gastric cancer during or after treatment in a tertiary acute-care hospital in Korea. Regular exercise was defined as regularly maintained aerobic exercise of at least moderate intensity consuming ≥4 metabolic equivalents for ≥150 min/wk for at least 6 months. Depression was measured using the 9-item version of the Patient Health Questionnaire, and HRQOL was assessed using the EORTC QLQ-C30. Patients who maintained aerobic exercise at a recommended level were less likely to have depression and more likely to have improved global QOL, as well as physical, role, and emotional functioning. Patients with depression were less likely to report improved global QOL and functioning. Thus, exercise can have a synergistic effect on improvement in HRQOL via indirect positive effects on depression and direct effects on HRQOL in patients with gastric cancer. Oncology nurses should encourage patients with gastric cancer who suffer from a depressive mood to set up and implement specific plans for practicing regular exercise, which can lead to an improvement in both depression and HRQOL.
Subcritical Hydrothermal Co-Liquefaction of Process Rejects at a Wastepaper-Based Paper Mill with Waste Soybean Oil
Authors: Shie Je-Lueng , Yang Wei-Sheng , Liau Yi-Ru , Liau Tian-Hui , Yang Hong-Ren
Published: April 2021

This study used the subcritical hydrothermal liquefaction technique (SHLT) in the co- liquefaction of process rejects at a wastepaper-based paper mill (PRWPM) and waste soybean oil (WSO) for the production of biofuels and bio-char material. PRWPM emits complicated waste composed of cellulose, hemicellulose, lignin, and plastic from sealing film. The waste is produced from the recycled paper process of a mill plant located in central Taiwan. The source of WSO is the rejected organic waste from a cooking oil factory located in north Taiwan. PRWPM and WSO are suitable for use as fuels, but due to their high oxygen content, their use as commercial liquid fuels is not frequent, thus making deoxygenation and hydrogenation necessary. The temperature and pressure of SHLT were set at 523–643 K and 40–250 bar, respectively. The experimental conditions included solvent ratios of oil–water, temperature, reaction time, and ratios of solvent to PRWPM. The analysis results contained approximated components, heating values, elements, surface features, simulated distillations, product compositions, and recovery yields. The HHV of the product occurred at an oil–water ratio of 75:25, with a value of 38.04 MJ kg−1. At an oil–water ratio of 25:75, the liquid oil-phase product of SHTL has the highest heating value 42.02 MJ kg−1. Higher WSO content implies a lower heating value of the oil-phase product. The simulated distillation result of the oil-phase product with higher content of alcohol and alkanes obtained at the oil–water ratio of 25:75 is better than the other ratios. Here, the carbon number of the oil product is between C8–C36. The product conversion rate rises with an increase of the WSO ratio. It is proved that blending soybean oil with water can significantly enhance the quality of liquefied oil and the conversion rate of PRWPM. Therefore, the solid and liquid biomass wastes co-liquefaction to produce gas and liquid biofuels under SHLT are quite feasible.
Estimation of Methane Production and Electrical Energy Generation from Municipal Solid Waste Disposal Sites in Pakistan
Authors: Sohoo Ihsanullah , Ritzkowski Marco , Sohu Zubair Ahmed , Cinar Senem Önen , Chong Zhi Kai , Kuchta Kerstin
Published: April 2021

This work aimed to estimate the annual methane production from the municipal solid waste disposal sites in Pakistan. In this study, the Intergovernmental Panel on Climate Change (IPCC) default methodology was used to estimate theoretical methane formation potential of the waste disposal sites in major cities of Pakistan. The estimates of this study are based on the last population census conducted in the year 2017 and latest available data regarding the waste generation and management practices in the cities considered in the study. Results showed that 31.18 million tonnes of municipal solid waste (MSW) is generated annually. The top 10 major populated cities in Pakistan (with 20% share in country’s population) contributing 31% share in the total quantity of MSW generated in overall country. On average 50–60% of the MSW generated is collected and openly dumped at the designated waste disposal sites. After analyzing the data, we estimate that annually 12.8 MtCO2-eq of methane is emitted from the waste disposal sites in major cities considered in this study. The methane produced from the waste disposal sites can be sustainably utilized as a source of energy through transforming MSW disposal sites (open dumps) to sanitary landfills with methane capturing and utilization facilities. In the present scenario of waste management and methane formation potential, sanitary landfills would generate 62.35 MWh of electric power if 25% of the methane was recovered and utilized in power generation.
Validation of a 20 m Wind Turbine Blade Model
Authors: Willberg Christian , Ravi Rakesh , Rieke Johannes , Heinecke Falk
Published: April 2021

In the projects Smartblades and Smartblades 2 a full-scale 20 m rotor blade for the NREL CART3 wind turbine was designed, built and tested. The rotor blade was intended to have a strong bending–torsion coupling. By means of the experiments, the proof for the technology in question was supposed to be provided. The experimental work was accompanied by simulations. The aim of the paper was to describe and publish a reference finite element model for the 20 m rotor blade. The validation procedure is presented, as are the modelling strategy and the limitations of the model. The finite element model is created using quadratic finite shell elements and quadratic solid elements. Different data sets were used for the validation. First, the data of static test bench experiments were used. The validation comprised the comparison of global displacement and local strain measurements for various flap and edge bending tests and for torsion unit loading tests. Second, the blades’ eigenfrequencies and eigenvectors in clamped and free–free scenarios were used for validation. Third, the mass distributions of the finite element and real blade were investigated. The paper provides the evaluated experimental data, and all analysed scenarios and the corresponding finite element models in Abaqus, Ansys and Nastran and formats as a reference dataset.
Semi-Analytical Solution to Assess CO2 Leakage in the Subsurface through Abandoned Wells
Authors: Qiao Tian , Hoteit Hussein , Fahs Marwan
Published: April 2021

Geological carbon storage is an effective method capable of reducing carbon dioxide (CO2) emissions at significant scales. Subsurface reservoirs with sealing caprocks can provide long-term containment for the injected fluid. Nevertheless, CO2 leakage is a major concern. The presence of abandoned wells penetrating the reservoir caprock may cause leakage flow-paths for CO2 to the overburden. Assessment of time-varying leaky wells is a need. In this paper, we propose a new semi-analytical approach based on pressure-transient analysis to model the behavior of CO2 leakage and corresponding pressure distribution within the storage site and the overburden. Current methods assume instantaneous leakage of CO2 occurring with injection, which is not realistic. In this work, we employ the superposition in time and space to solve the diffusivity equation in 2D radial flow to approximate the transient pressure in the reservoirs. Fluid and rock compressibilities are taken into consideration, which allow calculating the breakthrough time and the leakage rate of CO2 to the overburden accurately. We use numerical simulations to verify the proposed time-dependent semi-analytical solution. The results show good agreement in both pressure and leakage rates. Sensitivity analysis is then conducted to assess different CO2 leakage scenarios to the overburden. The developed semi-analytical solution provides a new simple and practical approach to assess the potential of CO2 leakage outside the storage site. This approach is an alternative to numerical methods when detailed simulations are not feasible. Furthermore, the proposed solution can also be used to verify numerical codes, which often exhibit numerical artifacts.