bluuebunny/crossref_metadata_2025 huggingface dataset:
Perceptions of the COVID-19 vaccine and willingness to receive vaccination among health workers in Nigeria
Authors: Adejumo Oluseyi Ademola , Ogundele Olorunfemi Akinbode , Madubuko Cynthia Roli , Oluwafemi Rosena Olubanke , Okoye Ogochukwu Chinedum , Okonkwo Kenechukwu Chukwuemeka , Owolade Sunday Samson , Junaid Oladimeji Adedeji , Lawal Olutoyin Morenike , Enikuomehin Adenike Christianah , Ntaji Maureen Iru , Sokunbi Aisha , Timothy Aina Omodele , Abolarin Olatunji Sunday , Ali Emmanuel Olalekan , Ohaju-Obodo John Oghenevwirhe
Published: July 2021

Objectives: The study aimed to examine health workers’ perceptions of the coronavirus disease 2019 (COVID-19) vaccine in Nigeria and their willingness to receive the vaccine when it becomes available.Methods: This multi-center cross-sectional study used non-probability convenience sampling to enroll 1,470 hospital workers aged 18 and above from 4 specialized hospitals. A structured and validated self-administered questionnaire was used for data collection. Data entry and analysis were conducted using IBM SPSS ver. 22.0.Results: The mean age of respondents was 40±6 years. Only 53.5% of the health workers had positive perceptions of the COVID-19 vaccine, and only slightly more than half (55.5%) were willing to receive vaccination. Predictors of willingness to receive the COVID-19 vaccine included having a positive perception of the vaccine (adjusted odds ratio [AOR], 4.55; 95% confidence interval [CI], 3.50−5.69), perceiving a risk of contracting COVID-19 (AOR, 1.50; 95% CI, 1.25–3.98), having received tertiary education (AOR, 3.50; 95% CI, 1.40−6.86), and being a clinical health worker (AOR, 1.25; 95% CI, 1.01−1.68).Conclusion: Perceptions of the COVID-19 vaccine and willingness to receive the vaccine were sub-optimal among this group. Educational interventions to improve health workers' perceptions and attitudes toward the COVID-19 vaccine are needed.
Fundamentos del diseño gráfico de videojuegos
Authors: Rojas Camilo Fabian
Published: July 2021

El presente artículo corto hace muestra de los resultados parciales que se han obtenido dentro de la investigación en desarrollo, que hace parte del proceso de doctorado en diseño que se viene realizando en la Universidad de Palermo - Argentina.

La investigación tiene como fin la búsqueda de una teoría centrada en los elementos de diseño que componen a los videojuegos, para ello se debe reinterpretar los fundamentos del diseño gráfico, los cuales han sido establecidos teniendo en cuenta los productos visuales físicos y digitales de manera general. Así que para ello en la primera fase se ha planteado hacer uso de un método hermenéutico que permita desde la semiótica reinterpretar el significado de cada elemento de diseño teniendo en cuenta las características y cualidades de los videojuegos.
Uso de tecnologías emergentes en la enseñanza de la realidad urbana FAUD UNC Córdoba, Argentina
Authors: Mariconde María Marta , Incatasciato Adriana
Published: July 2021

En la sección Disertaciones sobre Diseño del Vol 7, Nº1 de la revista Designia, las autoras invitadas presentan un artículo corto de reflexión, en el que se exponen prácticas pedagógicas con tecnologías emergentes en la asignatura de Morfología III: Morfología Urbana, de la FAUD Universidad Nacional de Córdoba, Argentina.

El taller experimental toma como objeto de estudio al sector del Mercado Norte de la ciudad de Córdoba y allí propone el desarrollo de lecturas de ciudad, enfocadas en el análisis del color urbano, bajo la aplicación didáctica de herramientas tecnológicas como dispositivos y aplicaciones móviles e internet.

La metodología propuesta incluye el desarrollo de un mapeo digital colaborativo del sector, un relevamiento del color digital percibido y la conceptualización de los resultados a partir de un video de síntesis.

La experiencia, arroja resultados que permiten visualizar las ventajas de la tendencia educativa del aprendizaje móvil y el uso de los recursos tecnológicos. Se considera que el ejercicio motiva y dinamiza los procesos de enseñanza y aprendizaje y fomenta la construcción colaborativa del conocimiento.
Sistematización de la dialéctica del paisaje para la gestión participativa del espacio público
Authors: Berezovsky María
Published: July 2021

Para la sección Disertaciones sobre Diseño del Vol 8, Nº 1 de la revista Designia, la autora invitada presenta un artículo corto de reflexión, que se deriva del proyecto de investigación adelantado para conseguir el título de Magíster en Planiﬁcación y Diseño del Paisaje, de la Universidad Católica de Córdoba, Argentina.

En el texto, se reflexiona acerca de la enseñanza de la temática del paisaje en ámbitos universitarios, a partir del uso de herramientas digitales. De acuerdo con lo anterior, se presenta una propuesta pedagógica que incluye el diseño de un manual y un curso, para la planiﬁcación y adecuada intervención del paisaje.
Movilización de las narrativas y redes de apoyo en estudiantes con desempeño académico favorable: Una revisión empírica
Authors: Barrera Cortes Yudy Tatianaa , Agudelo Torres Daniela , Burgos Jenny Paola
Published: July 2021

El objetivo fue presentar una revisión sobre el desempeño académico y su relación con los factores asociados. La atención se centra en la posibilidad de generar procesos de movilización a partir de las narrativas de los estudiantes que tienen un bajo desempeño académico, desde la visibilización de los recursos posibilitadores de quienes tienen un desempeño académico favorable. La narrativa fue entendida desde la perspectiva ontológica del ser, es decir, como organizadora de la realidad de las personas. A partir de la consultoría sistémica, se obtuvo un escenario de intervención que buscaba favorecer la emergencia de narrativas más centradas en alternativas de solución que en el problema. Para dar cuenta de esta revisión se presentan tres categorías: Factores asociados, familia y consultoría y construcción de escenarios, las cuales se organizaron a partir de la revisión de 50 artículos que permitieron fortalecer la comprensión del fenómeno donde elementos como la implicación de la familia o la posibilidad del lenguaje como escenario interventivo, se configuran como ejes fundamentales dentro de la investigación.
Alcances y limitaciones de Programas de Entrenamiento Cognitivo Computarizado Dirigidos al Trastorno por déficit de atención con hiperactividad
Authors: Cruz Sonia Gisela Rios , Blanco Parga María Lucia , Chacón Ruiz Jhon Erick , Contreras Cifuentes Angie Tatiana , Corredor Maria Fernanda , Martínez Cárdenas Juliana , Muñoz Valdés Ana Lorena , Palencia Amaya Valeria Valentina , Penagos Fajardo Luz Adriana Milena , Zapata Orjuela Maria Fernanda
Published: July 2021

Antecedentes: En los últimos años se ha incrementado la utilización de programas de entrenamiento cognitivo computarizado (ECC) como una alternativa terapéutica no invasiva, basados en la capacidad del cerebro para modificarse estructural y funcionalmente. Dirigidos a beneficiar tanto a  la población sana como la diagnosticada con un trastorno específico, incluyendo allí el Trastorno por déficit de atención con hiperactividad (TDAH). Sin embargo, su efectividad y la posibilidad de transferir los resultados a la vida cotidiana, aún es un tema controversial. El presente estudio tuvo como objetivo identificar los alcances y limitaciones de programas de ECC dirigidos a niños con TDAH.

Método: Se tomó como referente artículos publicados en revistas científicas registradas en la base de datos PROQUEST, durante los años 2008 a 2018, bajo los comandos “cognitive training”, “ADHD”, “children y youth”.

Resultados: Se ubicaron 1229 artículos, en la  búsqueda manual de la lista de referencia se identificaron 6 estudios que cumplieron con los requisitos de inclusión, es decir programas de ECC que fueron evaluados a través de estudios empíricos controlados, dirigidos a niños con TDAH.

Conclusiones: La revisión permitió identificar que en general el ECC es útil para el tratamiento del TDAH en lo que respecta a las dificultades atencionales o de memoria de trabajo; es ambigua la evidencia en lo que respecta a su impacto en la vida cotidiana
Efecto de reciprocidad y retroalimentación audiovisual en una tendencia cooperativa o egoísta
Authors: Sánchez Díaz Juan Manuel , Otálora Morales Diego Mauricio , Trout Garzón Tatiana Mercedes , Ovalle Zuleta Maria Alejandra
Published: July 2021

El objetivo del presente estudio es identificar el efecto de la presentaciónde vídeos que promueven conducta prosocial o egoísta, luego de haber desarrolladouna tendencia a comportarse de forma altruista o egoísta en la tarea experimentaldel dilema del prisionero. 70 estudiantes universitarios fueron expuestos a dosmodalidades del dilema del prisionero de 50 ensayos, con el fin de inducir dostendencias, una prosocial y otra egoísta. Posterior a los 50 ensayos, se presentó unvídeo que promovía la conducta opuesta a la tendencia previamente desarrolladay finalmente se realizó un último ensayo del dilema del prisionero. Los resultadosindican que existe un efecto estadísticamente significativo de reciprocidad en latarea del dilema del prisionero. No se observó una relación significativa entre lapresentación del vídeo y el cambio en la tendencia previamente desarrollada.
Purpose in Life During COVID-19 Confinement: Effect of Physical Activity and Meditation
Authors: Romero-Ramos Néstor , Romero-Ramos Óscar , Suarez Arnoldo José González
Published: July 2021

Introduction

The pandemic caused by the COVID-19 virus has led states to issue orders for confinement and suspension of activities such as education. The purpose of this study is to interpret the Purpose in Life Test (PIL) and its relationship to physical activity and mental relaxation/meditation in confinement.

Material and methods

A survey was conducted in an online form on 533 individuals (39 ± 11 years) using the Purpose in Life Test (PIL) and an ad-hoc questionnaire regarding physical activity time (PA), mental relaxation/meditation time (RM), hours of sleep (HS), number of people in confinement (NPC) and concerns and satisfaction during confinement.

Results

The overall mean of the PIL test was 114 ± 16, indicating a strong life purpose, and there were no differences by sex or by levels of physical activity, but for RM and age levels. The scores of the PIL test were positively correlated with the age, PA and time of RM. On the other hand, the main concern is the economy (50%) and health or getting sick by COVID-19 (37%), and what gives the greatest satisfaction is the family (40%) and sharing and spending time with the family (33%). People who perform RM activities at least 30 min/week have significantly higher PIL test scores.

Conclusions

Despite the drastic changes caused by confinement, individuals have a strong life purpose. Family companionship, home PA and RM act as a protective factor during confinement and in maintaining physical and mental health.
Implementing Simulationx in the Modelling of Marine Shafting Steady State Torsional Vibrations
Authors: Vulić Nenad , Bratić Karlo , Lalić Branko , Stazić Ladislav
Published: July 2021

Marine propulsion shafting systems are exposed to torsional vibrations originating from excitations in their prime movers and propellers. It is essential to analyse their steady state response in the earliest stage of ship design. The paper describes the implementation of SimulationX software based upon simulation modelling for these calculations. This software can be used either by the design office of the shipyard or by the classification society for verification within the plan approval phase. Some specifics of the input data preparation are briefly discussed. In addition, the simulation results depend on the modelling approach chosen. For these reasons, the real two-stroke Diesel engine ship propulsion system was chosen and several different models were implemented for system modelling. SimulationX calculation results are compared with those of two well-known and field-proven programs that use an analytical approach. Finally, the results are compared with the measurements performed on the actual newly built ship. Discussion reviews the selected SimulationX model, and its verification and validation in the case of engine cylinders with normal ignition.
Optimisation of the Topping-Up Process of Lubricating Oil in Medium-Speed Marine Engines
Authors: Młynarczak Andrzej , Rudzki Krzysztof
Published: July 2021

In this paper, we examine the problem of optimising the process of topping up lubricating oil in medium-speed marine engines. This process is one of the methods that can be applied to improve the properties of lubricating oil. The amount of fresh oil added to lubricating oil system always balances its consumption, but the method used to top up depends on the marine engineer. Small amounts of fresh oil can be added at short intervals, or large ones at long intervals, and the element of randomness often plays a significant role here. It would therefore be valuable to find a method that can help the mechanical engineer to choose the right strategy. We apply a multi-criteria optimisation method for this purpose, and assume that the criterion functions depend on the concentration of solid impurities and the alkalinity, which are among the most important aspects of the quality and properties of lubricating oil. These criterion functions form the basis for multi-objective optimisation carried out with the use of the MATLAB computer program.
Design Criteria for Scantling of Longitudinal and Transverse Connections in the Torsion Box Under Fatigue Loading
Authors: Silva-Campillo Arturo , Suárez-Bermejo Juan Carlos , Herreros-Sierra Miguel Ángel
Published: July 2021

Fatigue is one of the main failure modes in marine structures, and it is caused by the strong cyclic characteristics of the loads they support. This failure mode is amplified in areas of high stress concentration, such as at the intersection of primary and secondary elements. In this paper, a two-phase study is proposed that compares numerical and experimental results using a digital image correlation technique. The described procedure establishes selection, design, and scantling criteria and provides recommendations for the design of the transverse structure using specimens with different geometries. These geometries correspond to different designs for the transverse primary structure that use a longitudinal secondary stiffener with variable thickness and longitudinal spacing to transverse in a dynamic and quasi-static regime. The stress state for this regime is calculated based on the biaxiality indication concept, which uses the fatigue phenomenon (safety factor and sensitivity curves) and fracture mechanics (parameters of the Paris crack propagation law, correlation value, and law of variation of the stress intensity factor).
Proposal for the Evaluation of the Stability Level of Periodic Timetable in Terms of Operation and Infrastructure
Authors: Čechovič Lukáš , Šperka Adrián , Gašparík Jozef
Published: July 2021

The introduction of tact timetable in rail passenger transport is currently a new evolving trend that increases the efficiency of rail transport. This article seeks to contribute in this area of the issue and thus to raise and improve this system of organizing transport in railway transport. The aim is to propose a methodology that assesses the level of stability of tact timetable based on operational and infrastructural factors. The methodology identifies operational-infrastructural factors that affect the stability and reliability of tact timetable. Using scientific methods, it presents the method of their quantification and determination of the weights of these factors, which evaluate the line sections and transport points of the examined transport path. From a practical point of view, the methodology is generally tact applicable to other European railway networks. In the final part of the work, this methodological procedure is applied in the form of model examples for various transport path.
Impact of Signalling Device Failures in Context of the Railway Timetable
Authors: Gajdoš Adam , Vladislav Zitrický
Published: July 2021

The quality of the transport process in railway transport depends on the compliance of the timetable. Delays in rail transport are due to various reasons. One of the common factors is also failures in the stations or track interlocking systems. In the article is published the results of the performed simulation of failures of interlocking systems in the conditions of the transport laboratory at the Department of Railway Transport. The research was part of a student project solved at the University of Zilina.
Evaluation of Renewable Energy Investments from Public Financial Institutions
Authors: Čeryová Dominika , Ladvenicová Jana , Bajusová Zuzana
Published: July 2021

Renewable energy sources have become a compelling investment proposition, and investment into renewable power has grown in the recent years. Scale up renewable energy investment is critical to accelerate the global energy transformation and reap its many benefits, while achieving climate and development targets. Public finance institutions provide public money to support public and private sector projects as well as policies and programmes that serve the public good with economic, environmental, or social benefits. Several such institutions have been established and resourced with the aim of supporting renewable energy investments such as: international financial institutions, development finance institutions, local financial institutions, export credit agencies, and climate finance institutions. The main aim of this paper was to analyze the investments provided by this type of institutions in the renewable energy sector in the world with a specific focus on European Union member states in 2009–2016.
Occipito-Cervical Fixation Surgical Experience
Authors:   Department of Neurosurgery, Shebin Elkom Teaching Hospital, Al Minufiyah, Egypt, Shamseldein Ramadan
Published: July 2021

Occipito-cervical lesions not uncommonbut usually fatal conditions. Pain, limitation of movements, and weakness, were the main complaints of patients with upper cervical lesions. Internal fixation and fusion almost is a successful way for treatment by different means. CT scan is the imaging modality of choice for evaluation.
Attitude towards Cross-Culture Exchange in the 1685 French Embassy to the Kingdom of Siam
Authors: Beese Benjamin M.
Published: July 2021

Traditional histories of Early Modern exchange tend to emphasize the dispersion and adoption (or rejection) of European science and culture. More recently, there has been an historiographical trend to see early modern international interactions as multi-direction exchanges in which all parties are altered in each interaction. The 1685 French-Jesuit Embassy to Siam provides an interesting opportunity to explore the implications of this multi-directional approach. Although this exchange had no significant, lasting impact on either Siam or France, the dynamics at play demonstrate how each party’s attitude towards the exchange impacted their ability to achieve their aims. This paper uses Guy Tachard’s first-hand account of the 1685 Embassy, Voyage to Siam, to explore the political, scientific, and religious exchanges that took place between the French and the Siamese. On each of these levels, the French were consistently concerned with their own perception and cultural superiority whereas the Siamese were primarily motivated by a desire for an intellectual exchange. The Siamese successfully gained scientific equipment and knowledge from the French Jesuits whereas the Jesuits failed to convert Siam to Christianity. Thus, this interaction shows how differing attitudes lead to tangible differences in the outcome of this cross-cultural interaction.
Análise dialógica do discurso: uma revisão sistemática integrativa
Authors: Destri Alana , Marchezan Renata
Published: July 2021

A análise do discurso fundamentada nos desenvolvimentos teórico-metodológicos do Círculo de Bakhtin vem sendo praticada no Brasil desde a difusão da tradução de suas obras. O termo análise dialógica do discurso (ADD), no entanto, só foi popularizado após a publicação de “Análise e teoria do discurso” de Brait em 2006 e, como tal, solidificou-se o domínio de importante e distinta área de análise do discurso. Desde então, muito se dissertou sobre sua metodologia e, com a franca expansão da área, torna-se importante constituir uma revisão sistemática integrativa que investigue de forma rigorosa os conhecimentos já construídos no campo. Em vista disso, o objetivo desta pesquisa é, por meio do método de revisão citado, identificar, reunir, apreciar e sintetizar as principais contribuições das publicações teórico-metodológicas acerca da ADD, a fim de organizar as discussões metodológicas fundamentais e contribuir para possíveis direcionamentos de análise discursiva de cunho bakhtiniano. Destacaram-se, assim, três principais focos metodológicos para a ADD: as relações dialógicas, os gêneros discursivos e as formas da língua. Para o estudo desses focos, mostraram-se recorrentes as atividades analíticas integradas nomeadas aqui como descrição, análise e interpretação. De modo único, tais atividades promovem o encontro constitutivo entre linguística e metalinguística na relação dialógica do objeto de estudo com o pesquisador e com outros discursos relacionáveis. Nesse processo, o ideário bakhtiniano é mobilizado de forma coerente a fim de compreender, profundamente, o enunciado concreto por meio da contínua atribuição de sentidos desenvolvidos na atuação conjunta de elementos de singularidade e estabilidade.
A randomized control study for evaluating the efficacy of individualized homoeopathic medicine as an adjuvant therapy in mild to moderate cases of COVID-19
Authors: Phansalkar Shirish Kamlakar , Pacharne Tejaswini Deoram , Somawanshi Navnath Hanumant , Parekh Bhavik Ramesh
Published: July 2021

Objectives:

Understanding the efficacy of indicated homoeopathic medicine as an adjuvant to standard treatment in improving the subjective and objective parameters in patients with mild to moderate confirmed cases of COVID-19.

Materials and Methods:

Study design: A prospective randomized control trial conducted at Deenanath Mangeshkar Hospital, Erandwane, Pune, wherein Group A received standard treatment along with indicated homoeopathic medicine (experimental group) and Group B received the standard treatment and placebo (control group). Sample size: Fifty confirmed COVID positive, randomly selected patients in Groups A and B.

Results:

The indicated homoeopathic medicine as an adjuvant reduced subjective distress in a statistically significant proportion. It also reduced oxygen requirement, shortened hospital stay, promoted early recovery, and reduced worsening of the patients and shifting into the intensive care unit (ICU). By day 4 of treatment, subjective symptoms in 56% of patients in the experimental group were completely resolved, compared to 15% in the control group. The oxygen requirement on day 4 reduced by 46.2% in the experimental group, remaining unchanged in the control group. None of the patients in the experimental group needed shifting to the ICU compared to 16.7% in the control group. The average hospital stay was 6 days in the experimental group, compared to 9 days in the control group.

Conclusion:

Homoeopathic medicines played a significant role in helping to relieve the subjective and objective parameters of COVID-19.
Adhesive splinting in the treatment of periodontal diseases (clinical observation)
Authors: Kukushkin V. L. , Dashi-Dondokova A. O. , Kukushkina E. A.
Published: July 2021

.
Comparative clinical evaluation of the effectiveness of treatment of traumatic lesions of the oral mucosa
Authors: Iordanishvili A. K.
Published: July 2021

Relevance.Treatment of traumatic lesions of the oral mucosa in individuals who use removable acrylic dentures is a pressing problem in dentistry.

The goalis a comparative assessment of the treatment of traumatic prosthetic stomatitis in patients using acrylic dentures with the use of various drugs for local use.

Material and methods.A comparative clinical observation of the treatment of traumatic prosthetic stomatitis in 52 people aged 61 to 79 years, using removable acrylic prostheses, with the use of local adhesive Solcoseril® dental adhesive paste (1 group) and gum gel with propolis ASEPTA® (group 2 ). To ensure the comparability of the obtained results and their reliability, a semi-quantitative method was used for visual assessment of the effectiveness of treating traumatic prosthetic stomatitis, which was assigned to each of the symptoms observed in patients that indicate the absence or severity of clinical symptoms.

The results of the study.Methods have been developed for determining the severity of traumatic prosthetic stomatitis and methods for assessing the effectiveness of its treatment, based on consideration of the most significant clinical symptoms of this pathology. It was established that on day 10 in group 1 of the study, the effectiveness of treatment was 82,1%, in group 2 – 81,17%.

Findings.A high effcacy of selected agents for the local treatment of traumatic lesions of the oral mucosa of prosthetic etiology has been shown.
Influence long-term use of statins on the course of inflammatory periodontal diseases in coronary artery disease patients
Authors: Petrova T. G. , Borodina N. B. , Yakhontov D. A. , Vanjunina V. V. , Peresvet L. D.
Published: July 2021

The relevance of the study is due to the high prevalence of inﬂammatory periodontal diseases in patients with cardiovascular pathology. Currently, for the treatment of ischemic heart disease (IHD), statins are used, which, in addition to hypolipidemic action, have anti-inﬂammatory properties, which can lead to an increase in the pressure of the inﬂammatory process, not only in heart vessels, but also in paradonte.

The aim of the study was to study the effect of prolonged use of statins on the course of inﬂammatory periodontal diseases in patients with IHD.

Materials and methods. A dental examination and study of the quality of life of 122 patients with ischemic heart disease (IHD) were performed. Surveyed were divided into two groups depending on the duration of receiving lipid-corrective therapy.

The results of the study. It has been established that in patients with coronary artery disease who take statins for a long time, the periodontal inﬂammation activity and the severity of its clinical manifestations are lower than in patients not using lipid-correcting therapy, which was accompanied by improvement in certain parameters of quality of life.
LOOKING BACK AS THE FOUNDATION FOR THE STRATEGIC DEVELOPMENT OF CONTROLLED SOCIO-ECONOMIC SYSTEMS
Authors: Тебекин Алексей Васильевич
Published: July 2021

Цель статьи - в интересах обеспечения эффективности формирования и реализации стратегии социально-экономического развития Российской Федерации на период до 2030 года проанализировать результаты реализации «Стратегии-2020», обсуждение которых не нашло должного отражения как в системе государственного управления, так и в научной среде. В качестве инструмента анализа результатов реализации «Стратегии-2020» в работе использован «взгляд назад» как элемент зрительной системы научной школы предпринимательства Й. Шумпетера. Выбор указанного инструмента обусловлен тем, что именно он дает понимание, на каком фундаменте реализации прошлых стратегий придется строить и реализовывать стратегии будущего развития управляемой социально-экономической системы. Научная новизна заключается в сформулированных на основе комплексного анализа результатов реализации «Стратегии-2020» рекомендациях по формированию «Стратегии-2030» социально-экономического развития Российской Федерации.

N the interests of ensuring the effectiveness of the formation and implementation of the strategy for the socio-economic development of the Russian Federation for the period up to 2030, the author has analyzed the results of the implementation of the «Strategy 2020» the discussion of which has not been properly reflected both in the public administration system and in the scientific community. As a tool for analyzing the results of the implementation of «Strategy 2020», the work uses a «look back» as an element of the visual system of the scientific school of entrepreneurship by J. Schumpeter. The choice of this tool is due to the fact that it is he who gives an understanding on what foundation the implementation of past strategies will have to build and implement strategies for the future development of a controlled socio-economic system. On the basis of a comprehensive analysis of the results of the implementation of the «Strategy-2020» recommendations were formulated for the formation of the “Strategy-2030” of the socio-economic development of the Russian Federation.
POLITICAL AND ECONOMIC ANALYSIS OF GLOBAL TRANSFORMATIONS
Authors: Шафранская Анастасия Максимовна
Published: July 2021

Автором представлен обзор проведенного на базе Московского государственного университета имени М.В. Ломоносова V Международного политэкономического конгресса (МПЭК), посвященного проблеме глобальных социально-экономических трансформаций и будущего России. Представлена тематика основных выступлений в рамках МПЭК. Сформулированы основные предложения по использованию инструментов политэкономического анализа глобальных трансформаций. Проанализирована политэкономия трансформационных процессов мировой социально-экономической системы, а также пути развития России в изменяющихся глобальных условиях.

The author provides an overview of the conducted on the basis of the Lomonosov. Moscow State University of the V International Political Economy Congress (IPEC), dedicated to the problem of global socio-economic transformations and the future of Russia. The topics of the main speeches in the framework of the IPEC are presented. The main proposals for the use of tools for the political economy analysis of global transformations are formulated. Analyzed the political economy of the transformation processes of the world socio-economic system, as well as the ways of development of Russia in the changing global conditions.
Posthuman Knowledge
Authors: Gemuend Julie
Published: July 2021

A review of Rosi Braidotti's Posthuman Knowledge (2019)
The Role of the Mdm2/MdmX E3 Ligase System in Carcinogenesis, and Current Chemotherapeutic Interventions: A Literature Review
Authors: Ives Rowan , Gandhi Krishna
Published: July 2021

Introduction: E3 (ubiquitin) ligases play a major role in the ubiquitin-proteasome system (UPS), responsible for the ubiquitination and degradation of various proteins. The UPS has many roles, including regulation of the cell cycle. To mediate these functions, there are many different types of E3s, each with different substrates. A major E3 system involved in oncogenesis is the Mdm2/MdmX system, which acts as a heterodimer to degrade the tumour suppressor, p53, responsible for inducing cell cycle arrest and/or apoptosis in cancer cells, as needed. Upon overexpression/hyperactivation through mutation, the Mdm2/MdmX system can promote carcinogenesis through increasing degradation of p53, preventing necessary cell cycle arrest/apoptosis in cancer cells.
Methods: A literature review was conducted to synthesize and analyze research on Mdm2/MdmX E3 overexpression/hyperactivation, and the treatment options available for cancers in which overexpression/hyperactivation plays a role.
Results: There are many types of mutations that may be present in cancer cells, however mutations leading to the inactivation of p53 are some of the most common. Inactivation of p53 can be achieved by direct gene mutation, or overexpression/hyperactivation of Mdm2/Mdmx. Current drugs target the expression of MdmX/Mdm2 or their binding interactions with p53. Inhibition of these interactions triggers apoptosis in cancer cells due to increased p53 activity. Therapies that have been developed to target the Mdm2/MdmX system include small molecule inhibitors such as Nutlins and MI compounds, as well as peptide drugs.
Discussion: Although direct mutations of p53 are commonly found in cancer, mutated p53 is not a viable drug target, so instead many treatment options specifically target a dysregulated Mdm2/MdmX system. Future studies should investigate novel drug targets, minimization of side effects, and treatment in the presence of mutations to other DNA repair systems.
Conclusion: This literature review aids in establishing an interdisciplinary perspective on the types of oncogenic mutations in the Mdm2/MdmX pathway, combining biochemical and mechanistic research with clinical applications and pharmacology, as well as identifying future drug targets involved in this system.
RECYCLING OF SPENT CATALYSTS FOR ENVIRONMENTAL PROTECTION
Authors: Cherkasova Tatiana G. , Isakova Irina V. , Tihomirova Anastasiya V. , Cherkasova Elizaveta V.
Published: July 2021

RECYCLING OF SPENT CATALYSTS FOR ENVIRONMENTAL PROTECTION
CIBERGEOGRAFÍA O EL SALTO DE LO TERRENAL A LO DIGITAL: LAS POSIBILIDADES Y RIESGOS DE UN MUNDO EN RED
Authors: BARRÍA HUIDOBRO CRISTIAN
Published: July 2021

Internet representa los cimientos de la sociedad interconectada de hoy, en donde además de remodelar la forma en que nos relacionamos con el mundo, también plantea desafíos a nuestra representación mental y gráfica de los espacios físicos. La integración de nociones virtuales en casi la totalidad de las interacciones en la sociedad moderna, ha evidenciado la necesidad de replantear algunas visiones tradicionales en diversos campos del saber. En este estudio abordamos el caso de la cibergeografía, disciplina emergente que si bien puede trazar sus raíces a los trabajos cartográficos del siglo XIX, no ha sido sino hasta las últimas décadas que ha visto un sustantivo incremento en la complejidad de las representaciones lógicas que requieren ser plasmadas en mapas, los cuales exigen una armonía con los componentes físicos que interactúan de alguna u otra forma, con el mundo virtual. A pesar de que, como casi todo el fenómeno “ciber”, la cibergeografía no cuenta con acuerdos 100% transversales a nivel de definiciones conceptuales, sí se han hecho avances epistemológicos importantes, llevando a la propuesta de ciertos criterios a la hora de plasmar cartográficamente los distintos niveles del ciberespacio, sin perder su relación con los elementos geográficamente tradicionales que componen el mundo físico.
CONFRONTACIÓN GEOPOLÍTICA EN EL INDO-PACÍFICO: TIEMPOS DE TURBULENCIA
Authors: LABBÉ VILLA ALFREDO
Published: July 2021

La confrontación en curso entre Estados Unidos y China por la super-hegemonía global constituirá un fenómeno/proceso determinante en las relaciones internacionales del siglo XXI. Su impacto sobre la Paz y la Seguridad Internacionales (en el sentido empleado en la Carta de Naciones Unidas) se manifiesta en los desarrollos políticos y militares que tienen lugar en el Indo-Pacífico, incluyendo una verdadera carrera de armamentos. Los Estados del Indo-Pacífico serán los primeros en sentir la presión -directa o indirecta- de Beijing y Washington para acomodar su Política Exterior a las demandas de alineamiento. Este trabajo aborda esta confrontación a partir de las categorías de análisis desarrolladas por Graham Allison en su libro “Destined for War: can America and China escape Thucydides trap?”, en particular la dinámica que ha llevado a la guerra a contendientes previos. También desarrollos en China -políticos, militares, tecnológicos- que exacerbarían la colisión y sus consecuencias para el orden mundial. Concluye con una reflexión sobre la postura que un país como Chile debería asumir.
The Wine Industry & the COVID-19 Pandemic
Authors: Canavati Sergio , Bauman Matthew , Wilson Damien
Published: July 2021

When faced with extreme uncertainty and disruption, firms with superior knowledge and skills can not only identify more opportunities, but they can also envision how they will successfully exploit them. Firms that have developed the relevant knowledge, skills, and capabilities are more likely to act on perceived opportunities because they possess the expert schemas needed to focus on the most relevant information in the environment, process this information faster and more efficiently, and make decisions based on industry best practices. Despite the benefits of prior knowledge, deep expertise can also cause cognitive entrenchment leading experts to dismiss radically innovative and possibly disruptive ideas that fall outside the industry’s dominant paradigms.
Media Sosial, Word Of Mouth Dan Physical Environment Terhadap Proses Keputusan Pembelian
Authors: Suryana Debby
Published: July 2021

The purpose of this research are to analyze the influence of social media, word of mouth and physical environment on purchasing decision processes, and to analyze the dominant variables between social media, word of mouth, and physical environment for the purchasing decision process. The number of respondents in this study is 138 people. The data obtained analyzed using multiple linear regression analysis. The results showed that social media, word of mouth and physical environment had a significant effect on the purchasing decision process. Based on the results of multiple regression analysis, it can be seen that the largest regression coefficient value is the physical environment, this means that the physical environment is a variable that has a dominant influence on the purchasing decision process, followed by word of mouth and social media variables.
Peran Worklife Balance dan Stres Kerja terhadap Kinerja Karyawan dengan Organizational Citizenship Behavior sebagai Variabel Mediasi
Authors: Hikmah Miftahul , Lukito Hendra
Published: July 2021

The purpose of this study is to determine and analyze the effect of (1) Worklife balance on employee performance (2) Job Stress on employee performance (3) Worklife balance on OCB (4) Job Stress on OCB (5) OCB on employee performance (6) OCB as mediating role between Worklife balance and employee performance (7) OCB as mediating role between Job Stress and employee performance. The population in this study is employees of PT PLN (Persero) UP2B Sumbagteng, amounting to 50 people, with census techniques. Data analysis techniques using quantitative analysis with analysis tools SmartPLS 3.0. The results of this study found that: (1) Worklife Balance has a significant effect on employee performance (2) Job stress is contradictory and has a significant effect on OCB and employee performance (3) The magnitude of the effect of Worklife Balance on OCB is shown by the coefficient of determination R² of 0.261 or 26,1% (4) The magnitude of the influence of OCB on employee performance is shown by the coefficient of determination R² of 0.375 or 37,5% (5) Then there is also an indirect relationship with partial mediation by the OCB variable.
Analisis Peran Citra Perusahaan dan “Relationship Marketing” Terhadap Loyalitas Pelanggan Berbasis Kepercayaan Pelanggan pada PT. Dian Cipta Perkasa Jakarta
Authors: Soelistiawan Heroe , Lukitaningsih Ambar , Wiyono Gendro
Published: July 2021

Penelitian ini bertujuan untuk menguji pengaruh citra perusahaan dan relationship marketing terhadap kepercayaan dan loyalitas pelanggan pada business to business (B2B). Metode analisis data yang digunakan adalah structural equation modeling-partial least squares (SEM-PLS). Jumlah responden adalah 100 perusahaan. Teknik pengambilan sampel dalam penelitian ini dengan metode convinience sampling dimana pelanggan PT. Dian Cipta Perkasa adalah subjek dalam penelitian ini. Hasil penelitian menemukan bahwa citra perusahaan berpengaruh positif dan signifikan terhadap kepercayaan pelanggan, relationship marketing berpengaruh positif dan signifikan terhadap kepercayaan pelanggan, citra perusahaan tidak berpengaruh positif dan signifikan terhadap loyalitas pelanggan, relationship marketing berpengaruh positif dan signifikan terhadap loyalitas pelanggan dan kepercayaan berpengaruh positif dan signifikan terhadap loyalitas pelanggan. Secara umum ditemukan relationship marketing masih menjadi variabel yang paling menentukan dalam mendapatkan loyalitas pelanggan.
Rapid spread of the SARS-CoV-2 Delta variant in some French regions, June 2021
Authors: Alizon Samuel , Haim-Boukobza Stéphanie , Foulongne Vincent , Verdurme Laura , Trombert-Paolantoni Sabine , Lecorche Emmanuel , Roquebert Bénédicte , Sofonea Mircea T.
Published: July 2021

We analysed 9,030 variant-specific RT-PCR tests performed on SARS-CoV-2-positive samples collected in France between 31 May and 21 June 2021. This analysis revealed rapid growth of the Delta variant in three of the 13 metropolitan French regions and estimated a +79% (95% confidence interval: 52–110%) transmission advantage compared with the Alpha variant. The next weeks will prove decisive and the magnitude of the estimated transmission advantages of the Delta variant could represent a major challenge for public health authorities.
Real-world data shows increased reactogenicity in adults after heterologous compared to homologous prime-boost COVID-19 vaccination, March−June 2021, England
Authors: Powell Annabel A , Power Linda , Westrop Samantha , McOwat Kelsey , Campbell Helen , Simmons Ruth , Ramsay Mary E , Brown Kevin , Ladhani Shamez N , Amirthalingam Gayatri
Published: July 2021

Adults receiving heterologous COVID-19 immunisation with mRNA (Comirnaty) or adenoviral-vector (Vaxzevria) vaccines had higher reactogenicity rates and sought medical attention more often after two doses than homologous schedules. Reactogenicity was higher among ≤ 50 than > 50 year-olds, women and those with prior symptomatic/confirmed COVID-19. Adults receiving heterologous schedules on clinical advice after severe first-dose reactions had lower reactogenicity after dose 2 following Vaxzevria/Comirnaty (93.4%; 95% confidence interval: 90.5–98.1 vs 48% (41.0–57.7) but not Comirnaty/Vaxzevria (91.7%; (77.5–98.2 vs 75.0% (57.8–87.9).
Práticas de contabilidade e controlo de gestão no setor automóvel
Authors: Gomes Isabel , Silva Amélia , Vale José , Silva Anabela
Published: July 2021

A indústria automóvel foi muitas vezes considerada o berço de filosofias de gestão e de práticas de contabilidade e controlo de gestão inovadoras. Várias são as teorias que concorrem para explicar as motivações dos gestores na escolha do modelo de contabilidade e controlo de gestão nas organizações. A Nova Sociologia Institucional interpreta o comportamento das organizações integrando-as no contexto em que estas operam e explica o processo de adoção de práticas, regras e rotinas (instituições) de gestão como um mecanismo de adaptação ao meio, em busca de legitimação. Adotando esta perspetiva teórica, este trabalho pretende identificar os principais instrumentos de controlo de gestão utilizadas pelas empresas multinacionais da indústria de montagem automóvel a operar em Portugal e identificar as motivações que sustentaram a decisão de as implementar. Nesta investigação realizamos um estudo de caso múltiplo, analisando comparativamente quatro organizações. Os dados foram recolhidos a partir de múltiplas fontes, designadamente: entrevistas semiestruturadas, documentos e observação direta. Os resultados sugerem a existência de práticas isomórficas de contabilidade e controlo de gestão. No entanto, serão necessários estudos longitudinais para compreender como e porquê ocorrem estes processos de isomorfismo.
Solutions of problems for the wave equation with conditions on the characteristics
Authors: Korzyuk V. I. , Kovnatskaya O. A.
Published: July 2021

In this paper we obtain a classical solution of the one-dimensional wave equation with conditions on the characteristics for different areas this problem is considered in. The analytical solution is constructed by the method of characteristics. In addition, the uniqueness of the obtained solution is proved. The necessity and sufficiency of the matching conditions for given functions of the problem are proved. When these conditions are satisfied and the given functions are smooth enough, the classical solution of the considered problem exists.
Gadolinium contained scintillation glass for neutron detection in a wide energy range.
Authors: Korzhik M. V.
Published: July 2021

Inorganic scintillation glasses form a domain of rapidly evolving detector materials used to measure various types of ionizing radiation. The most widespread are lithium-silicate glasses enriched with the 6Li isotope, which are used to register thermal neutrons. At the same time, due to the specificity of the energy dependence of the neutron cross-section of light nuclei, such materials are of little use for the evaluation of epithermal and more highly energetic neutrons. The use of rare earth elements in the composition of glasses makes it possible to increase the sensitivity to neutrons. In the BaO–Gd2O3–SiO2 system, doped with Ce ions, a scintillation glass with a yield of at least 2500 photons / MeV was created for the first time, which permits to create inexpensive detector elements of a significant volume for registering neutrons. It has been shown that a detector based on BaO–Gd2O3–SiO2 glass has satisfactory properties when detecting neutrons in a wide spectrum of their energies.
Facial-onset sensory-motor neuronopathy, a rare variant of Huntington’s disease or chance association?
Authors: Raul Juntas-Morales , Elisa De La Cruz , Florence Esselin , Nicolas Pageot , Guillaume Taieb , William Camu
Published: July 2021

Objectives: To describe a patient with facial-onset sensory-motor neuronopathy (FOSMN) that later developed Huntington’s disease (HD). Case report: A 62-year-old woman complained of progressive dysphagia 8 years before referral. At initial evaluation, there was excessive salivation, dysphagia, and sensory-motor trigeminal impairment. Denervation was noted on the upper limbs and the tongue. Blink reflexes were abolished. Genetic study of amyotrophic lateral sclerosis (ALS)-related genes was normal. She was diagnosed with FOSMN syndrome. Her clinical state progressively worsened with corneal anesthesia, severe denutrition, right arm and axial weakness. Seven years after referral, she was unable walk and developed generalized chorea. Abnormal huntingtin gene repeat expansion confirmed the diagnosis of HD. She died 16 years after onset of dysphagia. Conclusion: Cases with both HD and ALS have already been reported but not FOSMN and HD, to our knowledge. Some FOSMN cases have been linked to ALS-related gene mutations and HD phenocopies have been associated with C9ORF72 repeat expansions. Recently, huntingtin repeat expansions were described in the ALS population. Although a chance association cannot be excluded, data from the literature are in favor of a pathogenic relationship between FOSMN and HD in this particular case. We suggest that huntingtin gene be more systematically studied in patients with FOSMN.