bluuebunny/crossref_metadata_2025 huggingface dataset:
Aspalathus linearis (Rooibos) Targets Adipocytes and Obesity-Associated Inflammation
Authors: Nehme Rawan , Chervet Arthur , Decombat Caroline , Longechamp Lucie , Rossary Adrien , Boutin Rebecca , Rousset Amandine , Senejoux François , Vachias Caroline , Auxenfans Céline , Fraisse Didier , Guyon Jean-Baptiste , Filaire Edith , Berthon Jean-Yves , Diab-Assaf Mona , Delort Laetitia , Caldefie-Chezet Florence
Published: April 2023

Excess weight and obesity are the fifth leading cause of death globally, and sustained efforts from health professionals and researchers are required to mitigate this pandemic-scale problem. Polyphenols and flavonoids found in Aspalathus linearis—a plant widely consumed as Rooibos tea—are increasingly being investigated for their positive effects on various health issues including inflammation. The aim of our study was to examine the effect of Rooibos extract on obesity and the associated low-grade chronic inflammatory state by testing antioxidant activity, cytokine secretions, macrophage polarization and the differentiation of human adipocytes through the development of adipospheroids. Rooibos extract significantly decreased ROS production and the secretion of pro-inflammatory cytokines (IFN-γ, IL-12, IL-2 and IL-17a) in human leukocytes. Additionally, Rooibos extract down-regulated LPS-induced macrophage M1 polarization, shown by a significant decrease in the expression of pro-inflammatory cytokines: TNFα, IL-8, IL-6, IL-1β and CXCL10. In addition, Rooibos inhibited intracellular lipid accumulation and reduced adipogenesis by decreasing the expression of PPARγ, Ap2 and HSL in adipospheroids. A significant decrease in leptin expression was noted and this, more interestingly, was accompanied by a significant increase in adiponectin expression. Using a co-culture system between macrophages and adipocytes, Rooibos extract significantly decreased the expression of all studied pro-inflammatory cytokines and particularly leptin, and increased adiponectin expression. Thus, adding Rooibos tea to the daily diet is likely to prevent the development of obesity associated with chronic low-level inflammation.
Nutrition-Related N-of-1 Studies Warrant Further Research to Provide Evidence for Dietitians to Practice Personalized (Precision) Medical Nutrition Therapy: A Systematic Review
Authors: Allman-Farinelli Margaret , Boljevac Brianna , Vuong Tiffany , Hekler Eric
Published: April 2023

N-of-1 trials provide a higher level of evidence than randomized controlled trials for determining which treatment works best for an individual, and the design readily accommodates testing of personalized nutrition. The aim of this systematic review was to synthesize nutrition-related studies using an N-of-1 design. The inclusion criterion was adult participants; the intervention/exposure was any nutrient, food, beverage, or dietary pattern; the comparators were baseline values, a control condition untreated or placebo, or an alternate treatment, alongside any outcomes such as changes in diet, body weight, biochemical outcomes, symptoms, quality of life, or a disease outcome resulting from differences in nutritional conditions. The information sources used were Medline, Embase, Scopus, Cochrane Central, and PsychInfo. The quality of study reporting was assessed using the Consort Extension for N-of-1 trials (CENT) statement or the STrengthening Reporting of OBservational Studies in Epidemiology (STROBE) guidelines, as appropriate. From 211 articles screened, a total of 7 studies were included and were conducted in 5 countries with a total of 83 participants. The conditions studied included prediabetes, diabetes, irritable bowel syndrome, weight management, and investigation of the effect of diet in healthy people. The quality of reporting was mostly adequate, and dietary assessment quality varied from poor to good. The evidence base is small, but served to illustrate the main characteristics of N-of-1 study designs and considerations for moving research forward in the era of personalized medical nutrition therapy.
Heat-Killed Lacticaseibacillus paracasei Repairs Lipopolysaccharide-Induced Intestinal Epithelial Barrier Damage via MLCK/MLC Pathway Activation
Authors: Xie Zhixin , Zhang Gongsheng , Liu Rongxu , Wang Yucong , Tsapieva Anna , Zhang Lili , Han Jianchun
Published: April 2023

Intestinal epithelial barrier function is closely associated with the development of many intestinal diseases. Heat-killed Lacticaseibacillus paracasei (HK-LP) has been shown to improve intestinal health and enhance immunity. However, the function of HK-LP in the intestinal barrier is still unclear. This study characterized the inflammatory effects of seven HK-LP (1 μg/mL) on the intestinal barrier using lipopolysaccharide (LPS) (100 μg/mL)-induced Caco-2 cells. In this study, HK-LP 6105, 6115, and 6235 were selected, and their effects on the modulation of inflammatory factors and tight junction protein expression (claudin-1, zona occludens-1, and occludin) were compared. The effect of different cultivation times (18 and 48 h) was investigated in response to LPS-induced intestinal epithelial barrier dysfunction. Our results showed that HK-LP 6105, 6115, and 6235 improved LPS-induced intestinal barrier permeability reduction and transepithelial resistance. Furthermore, HK-LP 6105, 6115, and 6235 inhibited the pro-inflammatory factors (TNF-α, IL-1β, IL-6) and increased the expression of the anti-inflammatory factors (IL-4, IL-10, and TGF-β). HK-LP 6105, 6115, and 6235 ameliorated the inflammatory response. It inhibited the nuclear factor kappa B (NF-κB) signaling pathway-mediated myosin light chain (MLC)/MLC kinase signaling pathway by downregulating the Toll-like receptor 4 (TLR4)/NF-κB pathway. Thus, the results suggest that HK-LP 6150, 6115, and 6235 may improve intestinal health by regulating inflammation and TJ proteins. Postbiotics produced by these strains exhibit anti-inflammatory properties that can protect the intestinal barrier.
Insulin Sensitization by PPARγ and GLUT-4 Overexpression/Translocation Mediates the Antidiabetic Effect of Plantago australis
Authors: Estrada-Soto Samuel , Ornelas-Mendoza Kathia , Navarrete-Vázquez Gabriel , Chávez-Silva Fabiola , Almanza-Pérez Julio Cesar , Villalobos-Molina Rafael , Ortiz-Barragán Erandi , Loza-Rodríguez Hilda , Rivera-Leyva Julio César , Flores-Flores Angélica , Perea-Arango Irene , Rodríguez-Carpena Javier-German , Ávila-Villarreal Gabriela
Published: April 2023

Plantago australis Lam. Subsp. hirtella (Kunth) Rahn is a medicinal plant used as a diuretic, anti-inflammatory, antibacterial, throat cancer treatment and for the control of diabetes. P. australis was collected in the state of Morelos, México. The hydroalcoholic extract (HAEPa) of P. australis was obtained by maceration and concentrated in vacuo. Once dry, it was evaluated through an oral glucose tolerance test (OGTT) in normoglycemic mice and in a non-insulin-dependent diabetic mice model. The expression of PPARγ and GLUT-4 mRNA was determined by rt-PCR, and GLUT-4 translocation was confirmed by confocal microscopy. The toxicological studies were conducted in accordance with the guidelines suggested by the OECD, sections 423 and 407, with some modifications. HAEPa significantly decreased glycemia in OGTT curves, as well as in the experimental diabetes model compared to the vehicle group. In vitro tests showed that HAEPa induced an α-glucosidase inhibition and increased PPARγ and GLUT-4 expression in cell culture. The LD50 of HAEPa was greater than 2000 mg/kg, and sub-chronic toxicity studies revealed that 100 mg/kg/day for 28 days did not generate toxicity. Finally, LC-MS analysis led to the identification of verbascoside, caffeic acid and geniposidic acid, and phytochemical approaches allowed for the isolation of ursolic acid, which showed significant PPARγ overexpression and augmented GLUT-4 translocation. In conclusion, HAEPa induced significant antidiabetic action by insulin sensitization through PPARγ/GLUT-4 overexpression.
Association between Gallstone Disease and Statin Use: A Nested Case—Control Study in Korea
Authors: Kwon Mi Jung , Lee Jung Woo , Kang Ho Suk , Lim Hyun , Kim Eun Soo , Kim Nan Young , Choi Hyo Geun , Kim Min-Jeong
Published: April 2023

The correlation between statin use and the development of gallstone disease remains controversial. Existing data, primarily based on Caucasian populations, are biased, thus necessitating validation studies involving Asian cohorts. We conducted a nested case–control study using data from the Korean National Health Insurance Service Health Screening Cohort (2002–2019) to determine the likelihood of gallstone disease according to periods of previous statin use and type of statin. Among the 514,866 participants, 22,636 diagnosed with gallstones at ≥2 clinic visits (using the International Classification of Diseases, 10th revision, code K80) were matched 1:4 to 90,544 controls for age, sex, income, and residential area, and their statin prescription history for 2 years prior to the index date was examined. Propensity-score-weighted odds ratios (ORs) for gallstone disease were calculated using conditional logistic regression. Long-term use (>545 days) of any statin or lipophilic statins was associated with lower odds of incident gallstones (OR = 0.91, 95% confidence interval [CI] = 0.86–0.96, p < 0.001 and OR = 0.88, 95% CI = 0.83–0.93, p < 0.001, respectively) after adjusting for confounders. Short-term use (180–545 days) of any statin or hydrophilic statins was not statistically related to incident gallstones. In summary, prior statin medication, particularly long-term lipophilic statin use, may confer a preventive advantage against gallstone disease.
Effect of Excipients on the Quality of Drug Formulation and Immediate Release of Generic Metformin HCl Tablets
Authors: Arafat Mosab , Sakkal Molham , Yuvaraju Priya , Esmaeil Anna , Poulose Vijo , Aburuz Salahdein
Published: April 2023

Generic medications are bioequivalent to brand-name medications, but the quality and purity of generic medications are still debatable. The aim of this study was to compare the generic product of metformin (MET) to its branded counterpart using pure MET powder as a reference. Quality control tablet assessment and in vitro evaluation of drug release were carried out in various pH media. Additionally, several analytical methods and thermal techniques were used, namely differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier-transform infrared (FTIR), and confocal Raman microscopy. The results showed a significant difference between the two products. In terms of friability assessment, mean resistance force, and tablet disintegration, the generic MET product showed significant weight loss, higher mean resistance force, longer disintegration time, and a slower rate of drug release. In addition, DSC and TGA showed that the generic product had the lowest melting point and the least weight loss compared to the branded product and pure powder. XRD and SEM demonstrated some changes in the crystallinity structure of the molecule particles for the generic product. Additionally, FTIR and confocal Raman revealed the same peaks and band shifts in all samples, but with differences in the intensity for the generic tablet only. The observed differences could be due to the use of different excipients in the generic product. The possibility of forming a eutectic mixture between the polymeric excipient and metformin in the generic tablet was presumed, which might be attributed to alterations in the physicochemical properties of the drug molecule in the generic product. In conclusion, using different excipients might have a significant effect on the physicochemical properties of drugs in generic formulations, leading to significant changes in drug release behavior.
The Current Status, Challenges, and Future Potential of Therapeutic Vaccination in Glioblastoma
Authors: Neth Bryan J. , Webb Mason J. , Parney Ian F. , Sener Ugur T.
Published: April 2023

Glioblastoma (GBM) is the most common malignant primary brain tumor and confers a dismal prognosis. With only two FDA-approved therapeutics showing modest survival gains since 2005, there is a great need for the development of other disease-targeted therapies. Due, in part, to the profound immunosuppressive microenvironment seen in GBMs, there has been a broad interest in immunotherapy. In both GBMs and other cancers, therapeutic vaccines have generally yielded limited efficacy, despite their theoretical basis. However, recent results from the DCVax-L trial provide some promise for vaccine therapy in GBMs. There is also the potential that future combination therapies with vaccines and adjuvant immunomodulating agents may greatly enhance antitumor immune responses. Clinicians must remain open to novel therapeutic strategies, such as vaccinations, and carefully await the results of ongoing and future trials. In this review of GBM management, the promise and challenges of immunotherapy with a focus on therapeutic vaccinations are discussed. Additionally, adjuvant therapies, logistical considerations, and future directions are discussed.
Smart pH- and Temperature-Sensitive Micelles Based on Chitosan Grafted with Fatty Acids to Increase the Efficiency and Selectivity of Doxorubicin and Its Adjuvant Regarding the Tumor Cells
Authors: Zlotnikov Igor D. , Streltsov Dmitriy A. , Ezhov Alexander A. , Kudryashova Elena V.
Published: April 2023

The main factors that determine the low effectiveness of chemotherapy are the low target bioavailability of antitumor drugs and the efflux process. In attempts to overcome this problem, several approaches are proposed here. Firstly, the development of polymeric micellar systems based on chitosan grafted by fatty acids (different types to optimize their properties), which, on the one hand, increase the solubility and bioavailability of cytostatics and, on the other hand, effectively interact with tumor cells due to the polycationic properties of chitosan, allowing for more effective penetration of cytostatic drugs into the cells. Secondly, the use of adjuvants—synergists of cytostatics (such as eugenol) included in the same micellar formulation—that selectively enhance the accumulation and retention of cytostatics in the tumor cells. pH- and temperature-sensitive polymeric micelles developed show high entrapment efficiency for both cytostatics and eugenol (EG) > 60% and release the drug in a prolonged manner for 40 h in a weakly acidic medium corresponding to the microenvironment of tumors. In a slightly alkaline environment, the drug circulates longer (more than 60 h). The thermal sensitivity of micelles is realized due to an increase in the molecular mobility of chitosan, which undergoes a phase transition at 32–37 °C. The effect of the cytostatic drug doxorubicin (Dox) on cancerous A549 cells and model healthy cells of human embryonic renal epithelium (HEK293T) was studied by FTIR spectroscopy and fluorescence microscopy. Micellar Dox penetrates into cancer cells 2–3 times more efficiently when using EG adjuvant, which inhibits efflux, as demonstrated by a significant increase in the ratio of intra- and extracellular concentrations of the cytostatic. However, here it is worth remembering about healthy cells that they should not be damaged: according to changes in the FTIR and fluorescence spectra, the penetration of Dox into HEK293T when using micelles in combination with EG is reduced by 20–30% compared to a simple cytostatic. Thus, experimental developments of combined micellar cytostatic drugs have been proposed to increase the effectiveness of cancer treatment and overcome multiple drug resistance.
The Role of Gut Microbiome in Psoriatic Arthritis—A Literature Review
Authors: Alexandru Cristina , Iorgus Carmen Catalina , Melesteu Ionut , Șerban Elena Daniela , Bobircă Florin , Constantin Maria Magdalena , Simu Razvan , Ancuța Ioan , Bojincă Mihai , Bobircă Anca
Published: April 2023

Psoriatic arthritis is a heterogeneous chronic autoimmune disorder characterized principally by skin lesions, arthritis, dactylitis and enthesitis. The exact etiology of the disease is yet to be discovered, with genetic predisposition alongside environmental factors being a well-known theory. In recent years, new discoveries have emphasized the role of gut microbiome in perpetuating inflammation in spondylarthritis. The exact mechanism through which dysbiosis underlies the pathophysiology of psoriatic arthritis is not defined. One of the current areas of focus in rheumatic research with new studies emerging annually is the link between microbiome and psoriatic arthritis. In this review, we synthesized the recent knowledge on intestinal microbiome and psoriatic arthritis. We screened two databases for articles, PubMed and Medline, using the following keywords: “microbiome”, “microbiota” and “psoriatic arthritis”. We described the current expertise on diversity and composition of gut microbiome in psoriatic arthritis, comparing the results with other inflammatory diseases. In the future, preventing the dysbiosis process that leads to the development of psoriatic arthritis could open the door to new therapeutic modalities. Moreover, fecal microbiota transplantation and probiotics’ benefits in modulating the gut microbiome are being intensively researched at the moment.
Dynamics of Endogenous Auxin and Its Role in Somatic Embryogenesis Induction and Progression in Cork Oak
Authors: Carneros Elena , Sánchez-Muñoz Jorge , Pérez-Pérez Yolanda , Pintos Beatriz , Gómez-Garay Aránzazu , Testillano Pilar S.
Published: April 2023

Somatic embryogenesis (SE) is a feasible in vitro regeneration system with biotechnological applications in breeding programs, although, in many forest species, SE is highly inefficient, mainly due to their recalcitrance. On the other hand, SE represents a valuable model system for studies on cell reprogramming, totipotency acquisition, and embryogenic development. The molecular mechanisms that govern the transition of plant somatic cells to embryogenic cells are largely unknown. There is increasing evidence that auxins mediate this transition and play a key role in somatic embryo development, although data on woody species are very limited. In this study, we analyzed the dynamics and possible role of endogenous auxin during SE in cork oak (Quercus suber L.). The auxin content was low in somatic cells before cell reprogramming, while it increased after induction of embryogenesis, as revealed by immunofluorescence assays. Cellular accumulation of endogenous auxin was also detected at the later stages of somatic embryo development. These changes in auxin levels correlated with the expression patterns of the auxin biosynthesis (QsTAR2) and signaling (QsARF5) genes, which were upregulated after SE induction. Treatments with the inhibitor of auxin biosynthesis, kynurenine, reduced the proliferation of proembryogenic masses and impaired further embryo development. QsTAR2 and QsARF5 were downregulated after kynurenine treatment. Our findings indicate a key role of endogenous auxin biosynthesis and signaling in SE induction and multiplication, as well as somatic embryo development of cork oak.
Bioinformatics and Expression Analysis of the Chitinase Genes in Strawberry (Fragaria vesca) and Functional Study of FvChi-14
Authors: He Tiannan , Fan Jianshuai , Jiao Gaozhen , Liu Yuhan , Zhang Qimeng , Luo Ning , Ahmad Bilal , Chen Qingxi , Wen Zhifeng
Published: April 2023

Plant chitinases (EC 3.2.1.14) are pathogenesis-related (PR) proteins and are well studied in many plant species. However, little is known about the genomic organization and expression of chitinase genes in strawberries (Fragaria vesca). Here, 23 FvChi genes were identified in the genome of strawberry (F. vesca) and divided into GH18 and GH19 subfamilies based on phylogenetic relationships. A detailed bioinformatics analysis of the FvChi genes was performed, including gene physicochemical properties, chromosomal location, exon–intron distribution, domain arrangement, and subcellular localization. Twenty-two FvChi genes showed upregulation after Colletotrichum gloeosporioides infection. Following the exogenous application of SA, FvChi-3, 4, and 5 showed significant changes in expression. The ectopic expression of FvChi-14 in Arabidopsis thaliana increased resistance to C. higginsianum via controlling the SA and JA signaling pathway genes (AtPR1, AtICS1, AtPDF1.2, and AtLOX3). The FvChi-14 protein location was predicted in the cell wall or extracellular matrix. We speculate that FvChi-14 is involved in disease resistance by regulating the SA and JA signaling pathways. The findings of this study provide a theoretical reference for the functional studies of FvChi genes and new candidates for strawberry stress resistance breeding programs.
The Invasive Plant Impatiens glandulifera Manipulates Microbial Associates of Competing Native Species
Authors: Ab Razak Nadia , Gange Alan C. , Sutton Brian C. , Mansor Asyraf
Published: April 2023

Impatiens glandulifera or Himalayan balsam is one of the most invasive weeds across Europe and can seriously reduce native plant diversity. It often forms continuous monocultures along river banks, but the mechanisms of this arrested succession are largely unknown. Here, we investigated the effect of arbuscular mycorrhizal (AM) fungi on balsam competitive ability with two native plant species, Plantago lanceolata and Holcus lanatus. We also studied how competition with Impatiens affects colonisation by foliar endophytes and mycorrhizas of two other co-occurring native species, Urtica dioica and Cirsium arvense. Mycorrhizal colonisation reduced balsam growth when the plants were grown singly, but appeared to have little effect when balsam experienced intra- or interspecific competition. Competition with balsam together with the addition of mycorrhizas had no effect on P. lanceolata biomass, suggesting that the fungi were beneficial to the latter, enabling it to compete effectively with balsam. However, this was not so with H. lanatus. Meanwhile, competition with Impatiens reduced endophyte numbers and mycorrhizal colonisation in U. dioica and C. arvense, leading to enhanced susceptibility of these plants to insect attack. Himalayan balsam is known to degrade soil fungal populations and can also reduce foliar beneficial fungi in neighbouring plants. This allows the plant to compete effectively with itself and other native species, thereby leading to the continuous monocultures.
The Formation of Volume Transmission Gratings in Acrylamide-Based Photopolymers Using Curcumin as a Long-Wavelength Photosensitizer
Authors: Pacheco Katherine , Aldea-Nunzi Gabriela , Pawlicka Agnieszka , Nunzi Jean-Michel
Published: April 2023

Curcumin, a natural dye found in the Curcuma longa rhizome, commonly called turmeric, is used as a photosensitizer in acrylamide-based photopolymers for holographic data storage. We studied the absorbance of photopolymer films that show two absorption bands due to curcumin, acrylamide monomer (AA), and the crosslinking agent N,N′-methylenebisacrylamide (MBA). Analysis of the real-time diffraction efficiency of these films shows a maximum of 16% for the sample with the highest curcumin concentration. Moreover, increasing the curcumin load enhanced the refractive index contrast from 7.8 × 10−4 for the photopolymer with the lowest curcumin load to 1.1 × 10−3 for the photopolymer with the largest load. The sensitivity and diffraction efficiency of the recorded gratings also increased from 7.0 to 9.8 cm·J−1 and from 7.9 to 16% with the increase in curcumin load, respectively. Finally, the influence of NaOH on the photopolymerization of the AA-curcumin-based sample shows a diffraction efficiency increase with the NaOH content, revealing that the curcumin enol form is more efficient as a photosensitizer.
Scale Type Revisited: Some Misconceptions, Misinterpretations, and Recommendations
Authors: Feuerstahler Leah
Published: April 2023

Stevens’s classification of scales into nominal, ordinal, interval, and ratio types is among the most controversial yet resilient ideas in psychological and educational measurement. In this essay, I challenge the notion that scale type is essential for the development of measures in these fields. I highlight how the concept of scale type, and of interval-level measurement in particular, is variously interpreted by many researchers. These (often unstated) differences in perspectives lead to confusion about what evidence is appropriate to demonstrate interval-level measurement, as well as the implications of scale type for research in practice. I then borrow from contemporary ideas in the philosophy of measurement to demonstrate that scale type can only be established in the context of well-developed theory and through experimentation. I conclude that current notions of scale type are of limited use, and that scale type ought to occupy a lesser role in psychometric discourse and pedagogy.
Invigorating Interfaith Consciousness for the Common Good: Reimagining the Role of African Religion and Pentecostalism in Contemporary South Africa
Authors: Atabongwoung Gallous , Lütz Johannes M. , Austin Denise A.
Published: April 2023

Contemporary South Africa reflects complex, diverse, and evolving religious realities. Changes continue to manifest at the confluence of encounters between various religions and rapid changes in social institutions that affect, in one way or another, various religions in the nation. These realities are typically embedded in sociocultural contexts and give clarity and meaning to religious experiences. In the post-apartheid era, the spirit of openness toward religious tolerance often dwindles when it comes to interactions between African religion and Pentecostalism. When people understand why followers of other religions believe and practice their rituals and sacraments, this knowledge may help dispel mis- and disinformation and thereby construct inter-religious common ground. Using an extensive review of the relevant literature, this article investigates some of the factors that may limit harmony between African religion and Pentecostalism in South Africa. After providing some definitions and historical context, we discuss the power and legacy of anti-apartheid interfaith solidarity. We also explore ongoing factors hindering interfaith engagements between African religion and Pentecostalism in South Africa. We then explore opportunities for interfaith dialogue in South Africa. Utilizing Walter Hollenweger’s Pentecostal intercultural theology, we argue that expressive liturgy for biodiversity and sustainability, communal participation for reconciliation, and experiential spirituality focused on land care could provide a potential ‘fourth’ approach to interfaith dialogue for African religion and Pentecostalism in South Africa. This includes underappreciated albeit profitable interrelationships between Indigenous knowledge, traditional spirituality, and sustainable development. We also acknowledge some limitations and opportunities for future research. Finally, we offer a succinct concluding synthesis that recapitulates the paper’s main points. This article aims to invigorate interfaith consciousness through meaningful thematization of pertinent issues, including the articulation and application of relevant intercultural theology.
A Registration Algorithm for Astronomical Images Based on Geometric Constraints and Homography
Authors: Lin Bin , Xu Xiangpeng , Shen Zhihua , Yang Xia , Zhong Lijun , Zhang Xiaohu
Published: April 2023

The registration of astronomical images, is one of the key technologies to improve the detection accuracy of small and weak targets during astronomical image-based observation. The error of registration has a great influence on the trace association of targets. However, most of the existing methods for point-matching and image transformation lack pertinence for this actual scene. In this study, we propose a registration algorithm based on geometric constraints and homography, for astronomical images. First, the position changes in stars in an image caused by the motion of the platform where the camera had been stationed, were studied, to choose a more targeted registration model, which is based on homography transformation. Next, each image was divided into regions, and the enclosed stable stars were used for the construction of triangles, to reduce the errors from unevenly distributed points and the number of triangles. Then, the triangles in the same region of two images were matched by the geometric constraints of side lengths and a new cumulative confidence matrix. Finally, a strategy of two-stage estimation was applied, to eliminate the influence of false pairs and realize accurate registration. The proposed method was then tested on sequences of real optical images under different imaging conditions and confirmed to have outstanding performance in the dispersion rate of points, the accuracy of matching, and the error of registration, as compared to baseline methods. The mean pixel errors after registration for different sequences are all less than 0.5 when the approximate rotation angle per image is from 0.58 ×10−2 to 5.89 ×10−2.
Radiometric Terrain Flattening of Geocoded Stacks of SAR Imagery
Authors: Agram Piyush S. , Warren Michael S. , Arko Scott A. , Calef Matthew T.
Published: April 2023

We have described an efficient approach to radiometrically flatten geocoded stacks of calibrated synthetic aperture radar (SAR) data for terrain-related effects. We have used simulation to demonstrate that, for the Sentinel-1 mission, one static radiometric terrain-flattening factor derived from actual SAR imaging metadata per imaging geometry is sufficient for flattening interferometrically compliant stacks of SAR data. We have quantified the loss of precision due to the application of static flattening factors, and show that these are well below the stated requirements of change-detection algorithms. Finally, we have discussed the implications of applying radiometric terrain flattening to geocoded SAR data instead of the traditional approach of flattening data provided in the original SAR image geometry. The proposed approach allows for efficient and consistent generation of five different Committee of Earth-Observation Satellites (CEOS) Analysis-Ready Dataset (ARD) families—Geocoded Single-Look Complex (GSLC), Interferometric Radar (InSAR), Normalized Radar Backscatter (NRB), Polarimetric Radar (POL) and Ocean Radar Backscatter (ORB) from SAR missions in a common framework.
Data Comparison and Cross-Calibration between Level 1 Products of DPC and POSP Onboard the Chinese GaoFen-5(02) Satellite
Authors: Lei Xuefeng , Liu Zhenhai , Tao Fei , Dong Hao , Hou Weizhen , Xiang Guangfeng , Qie Lili , Meng Binghuan , Li Congfei , Chen Feinan , Xie Yanqing , Zhang Miaomiao , Fan Lanlan , Cheng Liangxiao , Hong Jin
Published: April 2023

The Polarization CrossFire (PCF) suite onboard the Chinese GaoFen-5(02) satellite has been sophisticatedly composed by the Particulate Observing Scanning Polarimeter (POSP) and the Directional Polarimetric Camera (DPC). Among them, DPC is a multi-angle sequential measurement polarization imager, while POSP is a cross-track scanning simultaneous polarimeter with corresponding radiometric and polarimetric calibrators, which can theoretically be used for cross comparison and calibration with DPC. After the data preprocessing of these two sensors, we first select local homogeneous cluster scenes by calculating the local variance-to-mean ratio in DPC’s Level 1 product projection grids to reduce the influence of scale differences and geometry misalignment between DPC and POSP. Then, taking the observation results after POSP data quality assurance as the abscissa and taking the DPC observation results under the same wavelength band and geometric conditions as the same ordinate, a two-dimensional radiation/polarization feature space is established. Results show that the normalized top of the atmosphere (TOA) radiances of DPC and POSP processed data at the nadir are linearly correlated. The normalized TOA radiance root mean square errors (RMSEs) look reasonable in all common bands. The DPC and POSP normalized radiance ratios in different viewing zenith angle ranges at different times reveal the temporal drift of the DPC relative radiation response. The RMSEs, mean absolute errors (MAEs), relative errors (REs), and scatter percentage of DPC degree of linear polarization (DoLP) falling within the expected error (EE = ±0.02) of POSP measured DoLP are better than 0.012, 0.009, 0.066, and 91%, respectively.
StreetAware: A High-Resolution Synchronized Multimodal Urban Scene Dataset
Authors: Piadyk Yurii , Rulff Joao , Brewer Ethan , Hosseini Maryam , Ozbay Kaan , Sankaradas Murugan , Chakradhar Srimat , Silva Claudio
Published: April 2023

Access to high-quality data is an important barrier in the digital analysis of urban settings, including applications within computer vision and urban design. Diverse forms of data collected from sensors in areas of high activity in the urban environment, particularly at street intersections, are valuable resources for researchers interpreting the dynamics between vehicles, pedestrians, and the built environment. In this paper, we present a high-resolution audio, video, and LiDAR dataset of three urban intersections in Brooklyn, New York, totaling almost 8 unique hours. The data were collected with custom Reconfigurable Environmental Intelligence Platform (REIP) sensors that were designed with the ability to accurately synchronize multiple video and audio inputs. The resulting data are novel in that they are inclusively multimodal, multi-angular, high-resolution, and synchronized. We demonstrate four ways the data could be utilized — (1) to discover and locate occluded objects using multiple sensors and modalities, (2) to associate audio events with their respective visual representations using both video and audio modes, (3) to track the amount of each type of object in a scene over time, and (4) to measure pedestrian speed using multiple synchronized camera views. In addition to these use cases, our data are available for other researchers to carry out analyses related to applying machine learning to understanding the urban environment (in which existing datasets may be inadequate), such as pedestrian-vehicle interaction modeling and pedestrian attribute recognition. Such analyses can help inform decisions made in the context of urban sensing and smart cities, including accessibility-aware urban design and Vision Zero initiatives.
Axial Load Measurement of Bolts with Different Clamping Lengths Based on High-Frequency Ultrasonic ZnO Film Sensor
Authors: Jing Xuechao , Dai Hongwei , Xu Wanli , Zhao Yue , Zhang Jun , Yang Bing
Published: April 2023

The ultrasonic testing method has been widely used for measuring the axial load of bolts. However, systematic calibrations are prerequisite if specific bolts have different clamping length configurations, which leads to low efficiency and measurement errors. The focus of this work was to measure the axial load of bolts with different clamping lengths by proposing a method of clamping length correction based on piezoelectric films in order to avoid the complicated calibration steps. Firstly, the relationship between longitudinal wave time-of-flight (TOF) and axial load under different clamping lengths was studied to correct the difference between the effective stress length and the actual clamping length. Secondly, the high-frequency ZnO piezoelectric film sensor was fabricated on the bolts to improve the accuracy of longitudinal wave TOF measurement. The results showed that the center frequency of the fabricated ultrasonic sensor reached 25 MHz, which could realize the high precision measurement of TOF. The proposed correction model proved to be effective for decreasing the measurement error below 2.7% in this experiment. In conclusion, the proposed method simplified the calibration procedure for different application configurations of the same bolt and realized the efficient measurement of bolt axial load.
Production Change Optimization Model of Nonlinear Supply Chain System under Emergencies
Authors: Zhang Jing , Wu Yingnian , Li Qingkui
Published: April 2023

Aiming at the problem that the upstream manufacturer cannot accurately formulate the production plan after the link of the nonlinear supply chain system changes under emergencies, an optimization model of production change in a nonlinear supply chain system under emergencies is designed. Firstly, based on the structural characteristics of the supply chain system and the logical relationship between production, sales, and storage parameters, a three-level single-chain nonlinear supply chain dynamic system model containing producers, sellers, and retailers was established based on the introduction of nonlinear parameters. Secondly, the radial basis function (RBF) neural network and improved fast variable power convergence law were introduced to improve the traditional sliding mode control, and the improved adaptive sliding mode control is proposed so that it can have a good control effect on the unknown nonlinear supply chain system. Finally, based on the numerical assumptions, the constructed optimization model was parameterized and simulated for comparison experiments. The simulation results show that the optimized model can reduce the adjustment time by 37.50% and inventory fluctuation by 42.97%, respectively, compared with the traditional sliding mode control, while helping the supply chain system to return the smooth operation after the change within 5 days.
Electrodeposited Carbonyl Functional Polymers as Suitable Supports for Preparation of the First-Generation Biosensors
Authors: Sýs Milan , Bártová Michaela , Mikysek Tomáš , Švancara Ivan
Published: April 2023

The aim of this electrochemical study was to ascertain which type of electrochemically deposited carbonyl functionalized polymer represents the most suitable electrode substrate for direct covalent immobilization of biological catalysts (enzymes). For this purpose, a triad of amperometric biosensors differing in the type of conductive polymers (poly-vanillin, poly-trans-cinnamaldehyde, and poly-4-hydroxybenzaldehyde) and in the functioning of selected enzymes (tyrosinase and alkaline phosphatase) has been compared for the biosensing of neurotransmitters (dopamine, epinephrine, norepinephrine, and serotonin) and phenyl phosphates (p-aminophenyl phosphate and hydroquinone diphosphate). The individual layers of the polymers were electrochemically deposited onto commercially available screen-printed carbon electrodes (type C110) using repetitive potential cycling in the linear voltammetric mode. Their characterization was subsequently performed by SEM imaging and attenuated total reflectance FTIR spectroscopy. Molecules of enzymes were covalently bonded to the free carbonyl groups in polymers via the Schiff base formation, in some cases even with the use of special cross-linkers. The as-prepared biosensors have been examined using cyclic voltammetry and amperometric detection. In this way, the role of the carbonyl groups embedded in the polymeric structure was defined with respect to the efficiency of binding enzymes, and consequently, via the final (electro)analytical performance.
Bulgarian Roma at the Dawn of the COVID-19 Pandemic
Authors: Maeva Mila , Erolova Yelis
Published: April 2023

With the establishment of the state of emergency in Bulgaria on 8 March 2020 due to the spread of the COVID-19 pandemic, several restrictive measures aimed at social distancing were being introduced, to which the public had a contractionary reaction. The so-called “COVID-19 nests” led to the quarantine of a number of settlements. The ski-resort town of Bansko and the village of Panicherevo were the first isolated settlements targeted by our study. We focused on the reactions of the local Roma population, which were largely determined by their perceptions and understandings of infectious disease. The research methodology included ethnographic field research carried out in 2021. The data from the semi-structured interviews and focus-group discussions presented local responses to the pandemic, which to a large extent also represented the diversity of attitudes not only in the Roma community but also in Bulgarian society. The main questions we focused on were the great extent to which Roma are creating ethno-cultural strategies to cope/overcome the pandemic and how they are responding to the emergency measures and subsequent vaccination at the national and local levels.
Group Size Buffers against Energetic Stress in Honeybee Workers (Apis mellifera)
Authors: Lattorff H. Michael G.
Published: April 2023

Individuals of the Western honeybee species, Apis mellifera, live in large groups of thousands of worker bees, a queen, and a few drones. Workers interact frequently with related individuals while performing various tasks. Although it is well understood why and under which conditions sociality can evolve, the consequences for individuals living in permanent groups are less well understood. As individuals of solitary species become stressed when kept at high density, it might be the opposite in obligate social species. Here, I use an experimental laboratory set-up to study the effect of varying group sizes on the magnitude and within-group variance of stress responses towards energetic and heat stress. While only a weak difference was found in the magnitude of an energetic stress response as a function of group size, the within-group variance showed a statistically significant positive relationship with group size for the glucose/trehalose ratio, a marker for energetic stress. The heat stress marker, hsp70AB gene expression, did not show any relationship to group size. Individuals of obligate social species seem to benefit from adaptations to permanent group living, e.g., buffering against stress, especially at a higher density of individuals. The consequences of infections and immune system activation in isolated individuals are discussed.
Predicting the Sustainability of Pickleball Competitions as a New Sport from the Behavioral Intention of Pickleball Players
Authors: Wang Songyan , Chen Chao-Chien , Chu Yen-Hsu , Lin Hsiao-Hsien , Ting Kuo-Chiang , Hsu Chin-Hsien
Published: April 2023

This study focused on predicting the behavioral intentions of pickleball players. It analyzed the predictability of pickleball players’ behavioral beliefs on their attitudes, normative beliefs on subjective norms, control beliefs on perceived behavioral control, attitudes on behavioral intentions, subjective norms on behavioral intentions, and perceived behavioral control on behavioral intentions. The subjects were pickleball players, and purposive sampling was adopted for the questionnaire survey. A total of 226 valid questionnaires were collected. The data were analyzed with descriptive statistics and structural equation modeling. The results show that behavioral beliefs had a significant impact on attitudes; normative beliefs had a significant impact on subjective norms; control beliefs had a significant impact on perceived behavioral control; attitudes had no significant impact on behavioral intentions; subjective norms had a significant impact on behavioral intentions; and perceived behavioral control had a significant impact on behavioral intentions. In the future, researchers are suggested to extensively collect empirical data from players of different levels in pickleball competitions through interviews or on-site observations, and the analyses based on relevant theories can be conducive to the predictive analysis of the behavioral intentions of pickleball players, and practical suggestions are proposed regarding the sustainability of pickleball competitions.
Solid-State Shear Milling for Recycling Aluminum–Plastic Packaging Waste: A Sustainable Solution for Mixed Plastic Waste
Authors: Wei Baojie , Li Liang , Ding Shiyu , Chen Ning , Bai Shibing , Yang Shuangqiao
Published: April 2023

The application of paper–aluminum–plastic packaging has been widely adopted in various fields such as the food and medical industries, owing to its exceptional preservation and obstruction properties. Nonetheless, the recycling process for paper and aluminum from this packaging type typically involves water pulping and solvent separation. The resulting residual waste, commonly known as multi-plastic waste (PMW), poses significant challenges in terms of separation and recycling. In this research article, we propose a solution for the recycling of PMW using solid-state shear milling (S3M). This process utilizes powerful three-dimensional shear force to achieve pulverization and excellent dispersion of multicomponent polymers, all while maintaining ambient temperature conditions. The thermoplastic processability of milled PMW powder was improved. The results indicate that a significant reduction in the the average particle size of PMW from 700 μm to 226 μm after 10 milling cycles, as evidenced by both a particle size analyzer and SEM. Furthermore, S3M processing leads to a good dispersion of PMW domains, as confirmed by the reduction in domain size from 9.64 μm to 2.65 μm. DSC and DMA reveal excellent compatibility between the components of the composite, resulting in improved mechanical properties such as tensile stress (from 14.03 MPa to 22.02 MPa) and unnotched impact strength (from 3.26 KJ/m2 to 4.82 KJ/m2). The findings suggest that S3M technology could be an effective and sustainable method for recycling PMW without any separation process, with promising industrial application.
A Qualitative Assessment of Natural and Anthropogenic Drivers of Risk to Sustainable Livelihoods in the Indian Sundarban
Authors: Banerjee Sumana , Chanda Abhra , Ghosh Tuhin , Cremin Emilie , Renaud Fabrice G.
Published: April 2023

In the Indian Sundarban, multiple attributes and interactions of natural hazards, exposure, and vulnerability pose severe threats to lives and livelihoods. Understanding the cause-and-effect relationships contributing to the risk of loss of sustainable livelihoods has become imperative but has not yet been holistically explored in a single study that provides a broader picture of all possible complex interactions. This study used the impact chain tool to holistically understand the risk that manifests as a result of interactions of hazards, exposure, and vulnerability. The secondary literature and authors’ observations helped us structure the first draft of the impact chain, which was further developed and validated through fourteen gender-disaggregated interviews with key informants and delta dwellers. This validation process identified the complex interconnections contributing to risk as experienced by experts and delta dwellers, which is seldom reflected through exclusively quantitative data. A quantitative analysis of the qualitative data strongly indicated that tropical cyclones, rainfall variability, and storms are the dominant hazards that affect social–ecological vulnerability manifested through mangrove degradation, land loss due to erosion, and embankment breaching. Social vulnerability is caused by processes and factors that are either directly or indirectly influenced by natural hazards and social–ecological factors. Processes such as increasing seasonal male migration, uncertain agricultural income, and a lack of hazard-resistant housing exacerbates social vulnerability. Embankment breaching, the salinization of land and water, land loss due to erosion, mangrove degradation, land conversion, and groundwater abstraction were identified as the fundamental threats that can lead to a loss of sustainable livelihoods of the people if left unaddressed.