bluuebunny/crossref_metadata_2025 huggingface dataset:
Ochoa Syndrome: A Comprehensive Exploration
Authors:   Hospital General Centro Médico Nacional La Raza , “Dr. Gaudencio González Garza”. México., Cruz Islas Gabriela , Palacios Raya Vanessa Iliana ,   Hospital de Especialidades Centro Médico Nacional La Raza “Dr. Antonio Fraga Mouret”. México., Hernández Ernesto Nápoles ,   Hospital General Centro Médico Nacional La Raza , “Dr. Gaudencio González Garza”. México., Martínez Juárez Diego ,   Hospital General Centro Médico Nacional La Raza , “Dr. Gaudencio González Garza”. México., Mayo Nava Francisco ,   Hospital General Regional 1 Lic. Ignacio García Téllez , Cuernavaca, México., Hernández Valdivia Carlos Emilio ,   Hospital General Centro Médico Nacional La Raza , “Dr. Gaudencio González Garza”. México., Sanabria Quinteros Dulce María ,   Hospital General de Zona #2 "Dr. Adolfo Felix Loustaunau". Hermosillo, México., Mora Marrufo Laura Aurora de la ,   Instituto Mexicano del Seguro Social. Hospital General de Zona No. 1 - Dr. Emilio Varela Lujan. Zacatecas, Zacatecas, México, Delgado Enríquez Raúl Alonso ,   Hospital General Centro Médico Nacional La Raza , “Dr. Gaudencio González Garza”. México.
Published: December 2023

Objective: Ochoa Syndrome, also recognized as Urofacial Syndrome, presents an intricate confluence of urological anomalies and distinctive facial expressions during micturition. This article endeavors to meticulously dissect the genetic underpinnings and clinical intricacies that define this rare genetic disorder, providing a comprehensive overview for clinicians, geneticists, and researchers. Methods: A thorough review of existing literature, genetic studies, and clinical case reports was conducted to synthesize the current understanding of Ochoa Syndrome. Molecular pathways implicated in the pathogenesis of Ochoa Syndrome, with a focus on the HPSE2 gene, were elucidated, providing a foundation for the exploration of potential therapeutic interventions. Results: Ochoa Syndrome emerges as a consequence of mutations in the HPSE2 gene, unraveling a cascade of molecular events intricately linked to neurogenic bladder dysfunction and unique facial grimacing during voiding. The clinical spectrum encompasses a range of urological challenges, necessitating a nuanced approach to patient management and care. Conclusion: This article illuminates the complexities of Ochoa Syndrome, offering a roadmap for clinicians and researchers to navigate the intricate genetic landscape. By elucidating the molecular labyrinth that underlies this syndrome, we aim to not only enhance diagnostic precision but also pave the way for targeted therapeutic interventions, thereby advancing our collective understanding and management of this rare genetic enigma. Through this exploration, we endeavor to foster a deeper appreciation for the intricacies of Ochoa Syndrome and underscore the imperative for continued research in the pursuit of optimal patient outcomes.
How to Reduce the Cardiac Risk, One of the Most Common Perioperative Complications Following Invasive Surgery in Gynecology
Authors:   Department of Medical Imaging and Clinical Semiology Faculty of Medicine, University of Medicine, Tirana, Bele M.D. Phd Sonila , Cane M.D. Jon ,   University Hospital of Obstetrics & Gynecology "Queen Geraldine", Tirana, Hoxha Ass. Prof. Liri ,   Department of Medical Imaging and Clinical Semiology Faculty of Medicine, University of Medicine, Tirana
Published: December 2023

The role of preoperative cardiac evaluation is to determine the medical condition of the patient's cardiovascular status .A history and cardiovascular examination are crucial to identify severe cardiac conditions such as unstable coronary syndromes, serious arrhythmias, decompensated HF, and valvular disease. These conditions would place the patient in a high surgical risk category. In some situations, an additional diagnostic cardiac evaluation is necessary on the basis of the results of the initial preoperative test. In an acute surgical emergency, preoperative evaluation might have to be limited to simple tests, such as a rapid assessment of cardiovascular vital signs, ECG, blood pressure, hematocrit, electrolytes, renal function, blood analysis. Only the most essential tests and interventions are appropriate until the acute surgical emergency is resolved. Under other, less urgent circumstances, the preoperative cardiac evaluation may lead to a variety of responses, including delay or cancellation of surgery until the cardiac problem has been clarified and treated appropriately. This ideally would include direct communication with the surgeon, anaesthesiologist, and other physicians, as well as discussion directly with the patient and, if appropriate, the family. Conclusion: Preoperative cardiac evaluation is very important for all the patients undergoing gynaecologic surgery because cardiac related perioperative complications are well-known in general practice.
A Systemic Review of Organophosphorus Poisoning by Analyzing the Case Report
Authors:   Department of pharmacy Practice, Thanthai roever college of pharmacy, Perambalur, Tamil Nadu, India., R. Tamil Mozhi , N Abinaya ,   Department of pharmacy Practice, Thanthai roever college of pharmacy, Perambalur, Tamil Nadu, India., H Rajamohamed ,   Department of pharmacy practice, JSS Academy of Higher Education and Research, Ooty, Tamil Nadu, India., Ali S Mohamed Akram ,   Department of pharmacy Practice, Thanthai roever college of pharmacy, Perambalur, Tamil Nadu, India., KM Shahul Hameed ,   Department of pharmacy Practice, Thanthai roever college of pharmacy, Perambalur, Tamil Nadu, India., R Nepolean ,   Department of pharmaceutics, Thanthai Roever Of College Of Pharmacy, Perambalur, Tamil Nadu, India.
Published: December 2023

Introduction: Poison is any substance that obstructs with ordinary body functions and is capable of affecting adverse effects in living organisms. Self-poisoning from organophosphorus [OP] pesticides is a significant clinical issue in rural areas of developing countries and is responsible for an estimated 2,00,000 fatalities annually. Suspicion recognizable clinical symptoms the odour of pesticides or solvents and decreased butyrylcholinesterase activity in the blood are used for diagnosis. Case Study: A 30 years old female patient was admitted in a Tertiary Care Hospital, with an alleged history of dimethoate compound poisoning. On arrival the patient was drowsy responds to painful stimuli and afebrile. The treatment was begin with Gastric lavage with normal saline Inj.Pralidoxime in an intravenous route and Atropine was also administered intravenously and repeated every 5 minutes until the pupil dilated and Ranitidine was given to prevent ulceration. Discussion: The initial method to treat organophosphorus poisoning is to decontaminate the patient by removing and destroying all clothing and using drying agent such as flour sand or bentonite. The patient's irrational usage of medication therapy causes a worsening of the condition and a 10- to 15-day hospitalization. Conclusion: As per the standard treatment guidelines, atropine should be given as first-line therapy because muscarinic effects are reversed by atropine. By providing this to the patient, you will minimise the severity of their illness minimise down on their stay in the hospital and ultimately save their lives.
Analysis of Financial Ratios to Assess Performance Regional Government Finance of Kediri City and Trenggalek Regency 2019-2021
Authors:   Faculty of Economic and Business, Kadiri University, Kediri, Indonesia, Prihardani Oktaviani Wahyu , Putri Dina Amelia ,   Faculty of Economic and Business, Kadiri University, Kediri, Indonesia, Rukmini Meme ,   Faculty of Economic and Business, Kadiri University, Kediri, Indonesia, riningsih Duwi ,   Faculty of Economic and Business, Kadiri University, Kediri, Indonesia, Eferyn Krissantina ,   Faculty of Economic and Business, Kadiri University, Kediri, Indonesia
Published: December 2023

The research aims to analyze financial ratios to assess the financial performance of local governments in Kediri City and Trenggalek Regency in 2019-2021. Research results 1) The independence ratio of the Kediri City Government in 2019-2020 shows a low independence ratio with a percentage of 26% and 27%, while for 2021 the independence criteria shows medium with a percentage value of 42%. The results with the Trenggalek Regency Government from 2019-2021 show a very low independence ratio. The effectiveness ratio in the city of Kediri in 2019-2021 shows the same result, which is very effective. The percentage results in 2019-2020 have the same value, which is 17%, while in 2021 it has a percentage of 15%. 2) The effectiveness ratio in the Kediri City Government in 2019-2021 has a percentage value greater than 100% so that it can be interpreted that the effectiveness ratio in this government is very effective. in 2019 it has a percentage of 107%, in 2020 it has a percentage of 110% and in 2021 it has a percentage of 168%. The results of the Trenggalek Regency Government in 2019 and 2021 have percentages of less than 100%, namely 95% and 91%, which means they are quite effective, while in 2020 they have a percentage of 101%, which means they are very effective. 3) The Efficiency Ratio in the City Government of Kediri in 2019 has a percentage of 94% which means efficient, in 2020 it has a percentage of 94% which means efficient and in 2021 it has a percentage of 89% which means efficient.
The Analysis of Antithesis and Oxymoron in “The Da Vinci Code”
Authors:   Azerbaijan University of Languages The candidate for a degree, Aliyeva Roya Yavar
Published: December 2023

The article deals with the linguistic analysis of antithesis and oxymoron in “The da Vinchi Code”. The extended information about the antithesis and oxymoron is provided in the article. “The da Vinchi Code” of D. Brown is proved to be enriched with antithesis and oxymoron. The use of both stylistic devices adds emotionality to the language of the fictions, and this in the expression of both the inner and outer world of the characters created in the fiction, their feelings and excitement to the smallest point have been observed in the article. Together with these stylistic devices, it is possible to draw a reader’s attention to the work more. The possibility of turning the phrases expressed by “as” into oxymarons by the transformation method is also dealt with. The article also deals with the investigation of how the oxymoron found in “The Da Vinci Code” was found to be more commonly used in a number of languages, and it was not difficult to determine that they were oxymorons. Besides, the existence of a purposeful use of such stylistic figures in the examples of fictionals is also taken into regard. Different patterns of oxymoron and antithesis are presented and analyzed in the article. It is estimated that these stylistic tools enrich the language of fictionals and add colorful shades to it. It is proved in the article, that transformation of some phrases into oxymoron is a complex process together with its elements. The ways of these two stylistic tools, which can be transformed from one to the other by the method of transformation, are dealt as well. Moreover different thoughts about the antithesis and oxymoron are provided in this article. It is also mentioned that each writer and poet has their own attitude to these linguistic phenomena.
Studying Taiwanese Tourists' Satisfaction with Da Nang Beach Tourism Products - Vietnam
Authors:   University of Sciences, Thai Nguyen University, Vietnam, Tien Nguyen Van , Trang Nghiem Thu ,   University of Sciences, Thai Nguyen University, Vietnam
Published: December 2023

Da Nang beach is very famous not only in Vietnam but all over the world. Da Nang beach tourism products are increasingly attracting international tourists, typically the market with high paying ability such as Taiwanese tourists. Studying satisfaction to improve the quality of Da Nang beach tourism products helps increase loyalty and attract visitors from the Taiwanese market. This is very necessary to promote the development of marine tourism - which is a potential tourism market to thrive in the current new normal period.
PENGARUH KEPEMIMPINAN KEPALA SEKOLAH TERHADAP KINERJA GURU DI SMP NEGERI 5 LEDO
Authors: Toni Toni , Aunurrahman Aunurrahman , Halida Halida
Published: December 2023

This research aims to determine the influence of the principal's leadership on teacher performance at SMP Negeri 5 Ledo. This research method is quantitative with a descriptive approach, with questionnaires supported by document studies and interviews to obtain optimal results. The population in this study were teachers at SMP Negeri 5 Ledo, the sample taken was 20 teachers, namely all teachers at SMP Negeri 5 Ledo. The results of the research show that there is an influence between the principal's leadership on teacher performance at SMP Negeri 5 Ledo. Judging from the results of the Persial test (T-Test), the Tcount value is 3.581 and the Ttable value is 2.042 with a significance value of 0.002. With the test criteria T count > T table and if significance < 0.05 then H0 is rejected so that there is a significant influence between the principal's leadership on teacher performance at SMP Negeri 5 Ledo. Then the coefficient of determination shows that the R square value is 0.416, namely the influence of the principal's leadership on teacher performance at SMP Negeri 5 Ledo is 25.2%. This means that the influence of the principal's leadership on teacher performance is in the low category out of a total of 100%. However, it can be suggested that school principals should have more control over teachers in making lesson plans and provide supervision over teachers so that their performance improves.
The promise of AI in medicine: A call for greater education for Pakistani medical professionals
Authors: Khan Muhammad Masharib , Malik Sumaira Malik , Vohra Fabiha Vohra
Published: December 2023

Madam,
AI is revolutionizing the world in all spheres and the institution of medicine worldwide is no exception. While we are most familiar with its contribution to radiology, AI has now extensive applications within dermatology, ophthalmology, pathology, medicine, ophthalmology, neurosciences and more. Through progressive efforts of both doctors and programmers, AI is now becoming more adept in the field of medicine. Some of its applications in modern medicine include staging of skin cancers by looking at dermatoscopic images (1), classifying age-related macular degeneration and diabetic macular edema by through OCT images (2), and more. The accuracy by which AI performs these tasks is comparable to a human being.
However, Pakistan being in the developing stage is still lagging behind. With inadequate resources, constant economic desolation, and limited knowledge and data in the field of IT, the country is far behind in this rapidly progressive field.
According to a study that included participants throughout Pakistan 74% of doctors and 68.8% of medical students had a basic knowledge of AI but only 27.3% of doctors and 19.4% of students were aware of its medical applications (3). In another study only 56.7% of the participants were familiar with AI and its subtypes, which highlighted the unawareness about AI in more than 40% of the participants. These studies clearly show the deficit in knowledge that medical personnel have about AI, its applications and impact on health care.
AI and its rapid progress in health sectors worldwide are creating discrepancies between them and us. Hence, the senior authorities in our education system should come up with a proposition that can shorten this gap. By introducing basic levels of AI in the medical curriculum with a course spanning only around 1 week, including basics of coding and computational thinking (5), our medical personnel will be able to incorporate a fundamental level of computational thinking and coding language. This will help them in adapting to the revolutionized healthcare system as well as give them enough command to grapple with it and give feedback to improvise AI even more. And since medical science is based on logical reasoning and problem-solving, much like IT, we believe that our medical students can and will be able to inculcate this into their skills. This can be our very first step towards a much more efficient and progressive healthcare system.
Self-reported musculoskeletal pain, headache, jaw pain and swallowing dysfunction in a sample of young Saudi adults who stutter
Authors: Almudhi Abdulaziz , Zafar Hamayun
Published: December 2023

Objective: To report the prevalence of musculoskeletal pain, headache, jaw pain and difficulty in swallowing among people who stutter (PWS).
Method: The cross-sectioal study was conducted from October 3, 2021, to March 21, 2022, after approval from the ethics review committee of King Khalid University, Abha, Saudi Arabia, and comprised adult people who stutter belonging to different regions of Saudi Arabia. They were divided into five groups based on stuttering severity as estimated by Stuttering Severity Instrument-4. Data was collected on musculoskeletal pain in different body areas using a questionnaire.. Data ws analysed using SPSS 22.
Results: Of the 101 Arabic-speaking subjects, 63(62.4%) were males and 38(37.6%) were females. The overall mean age was 27+/7 years (range: 18-39 years). The largest group was of subjects with moderate severity of stuttering 31(30.6%); 21(68%) males and 10(32%) females. The increase in number of musculoskeletal pain locations was related to the severity of stuttering (p<0.05). The most common musculoskeletal pain sites were the lower back 31(31%), neck 26(26%) and shoulder 26(26%). Frequent headaches and difficulty chewing hard food due to jaw pain were reported by 49(49%) and 22(22%) participants, respectively (p<0.05). Swallowing difficulty was reported by 9(9%) participants (p>0.05).
Conclusions: Widespread chronic musculoskeletal pain of low intensity was found to be common among people who stuttered, and the number of pain locations was positively related to stuttering severity.
Key Words: Stuttering, Musculoskeletal pain, Headache, Jaw, Deglutition.
Pulmonary barotrauma as a complication of mechanical ventilation for management of COVID-19 associated acute respiratory distress syndrome (CARDS)
Authors: Khan Shahmeer , Kiran Hilal  , Arshad Ainan , Nankani Avinash , Zehra Rizvi Syeda Zoha , Ul Haq Tanveer
Published: December 2023

Objectives: To identify that incidence of pulmonary barotrauma secondary to mechanical ventilation for the management of acute respiratory distress syndrome associated with coronavirus-disease-2019, and to compare it with the incidence of pulmonary barotrauma trauma secondary to mechanical ventilation associated with all the other causes.
Method: The retrospective case-control study was conducted at the Aga Khan University Hospital, Karachi, and comprised data from October 2020 to March 2021 of patients who underwent mechanical ventilation. The data was divided into two groups. Data of acute respiratory distress syndrome associated with coronavirus-disease-2019 was in group 1, and that of acute respiratory distress syndrome associated with any other cause in control group 2. Medical records were reviewed to obtain demographic and clinical data, while the institutional picture archiving and communication system was used to review radiological images. Data was analysed using SPSS 24.
Results: Of the 261 cases, 115(44%) were in group 1; 87(75.6%) males and 28(24.3%) females. There were 146(56%) controls in group 2; 96(65.7%) males and 50(34.2%) females. There were 142(54.4%) subjects aged >60 years; 61(43%) in group 1 and 81(57%) in group 2. The incidence of pulmonary barotrauma in group 1 was 39(34%) and 8(5.5%) in group 2 (p<0.0001).
Conclusion: Mechanical ventilation in the management of acute respiratory distress syndrome associated with coronavirus-disease-2019 was found to be associated with a significantly higher incidence of pulmonary barotrauma than acute respiratory distress syndrome associated with any other cause.
Key Words: COVID-19, Respiratory distress syndrome, Barotrauma, Pulmonary ventilation, Mediastinal emphysema.
Exenatide and Metformin Improve Serum Indices and Intestinal Flora in patients with Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease
Authors: Jiang Xiaojie , Shi Tingting , Han Dan , Chen Juan
Published: December 2023

The aim of the study was to investigate the influence of Exenatide combined with Metformin on fasting blood glucose, postprandial glucose, triglycerides, total cholesterol, alanine aminotransferase, aspartate aminotransferase, and intestinal flora in type 2 diabetes mellitus cases with non-alcoholic fatty liver disease. A total of 128 type 2 diabetes mellitus patients with non-alcoholic fatty liver disease, diagnosed from January 2019 to January 2022, were included and randomly assigned to either Group A (n=64) or Group B (n=64). Group A received Metformin, while Group B received Exenatide injection and Metformin. After 24 weeks of treatment, blood glucose indices (fasting blood glucose and postprandial glucose), blood lipid indices (triglycerides and total cholesterol), liver function indices (alanine aminotransferase and aspartate aminotransferase) were all lower in Group B than in Group A (P < 0.001 for all).
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Drug susceptibility, Prevalence and effect of Pseudomonas aeruginosa on wound healing from burn patients
Authors: Azam Saima , Mustafa Mohammad Zahid , Taj Muhammad Kamran , Mengal Muhammad Azam , Mengal Muhammad Alam , Hussain Ashiq
Published: December 2023

Objective: To determine the prevalence, antibiotic susceptibility and effect of Pseudomonas aeruginosa in relation to burn patients.
Method: The cross-sectional study was conducted at the Centre for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan, Quetta, Pakistan, from March 2018 to May 2021, and comprised pus swab cultures were isolated from inpatients with 2nd and 3rd degree burns aged up to 60 years at Bolan Medical Complex Hospital and Sandeman Provinical Hospital, the two main government tertiary care hospitals in Quetta. The samples were immediately cultured, and evaluated using biochemical tests, antibiotic susceptibility and molecular identification using polymerase chain reaction. Data was analysed using SPSS 20.
Results: Of the 720 burn wound samples, 424(58.9%) were positive for Pseudomonas aeruginosa; 304(42%) males and 120(16%) females (p<0.02). The overall mean age of the patients was 27.7±6.2 years (range: 1-60 years). The mean total burn surface area was not significantly different in positive 29.6±6.2% and negative 30.3±6.2% cases (p>0.05). The time leading to skin grafts in positive patients was 29.5±6.5 days compared to 22.3±6.3 days for negative patients (p< 0.007), and the time required for wound healing was 25.0±4.7 days and 16.7±5.2 days, respectively (p<0.001). Length of hospital stay of Pseudomonas aeruginosa positive patients was 38.0±7.8 days compared to 32.1±6.8 days for negative patients (p<0.001).
Conclusion: Nosocomial infections and multidrug resistance species were observed frequently at the burn wound site. P. aeruginosa.
Key Words: Antibiotics, antimicrobial resistance, burn wounds, nosocomial infection, Pseudomonas aeruginosa.
Retroperitoneal liposarcoma: case of a giant tumour inside the abdomen
Authors: Khan Shahzaib , Areeb Zafar  , Murk Lakhani  , Arsalan Baig  , Ali Hassan  , Owais Khan
Published: December 2023

Retroperitoneal liposarcomas are rare malignant tumours that often grow rapidly in size and become symptomatic late in the disease course, posing diagnostic and therapeutic challenges. Although abdominal imaging can reliably diagnose the tumour, definitive diagnosis is only possible through biopsy after surgical excision, which remains the primary treatment modality for these tumours. Long-term survival is primarily determined through histologic grade and post-resection tumour margins. We report the case of a 43-year-old male patient, seen at Dr Ruth KM Pfau Hospital Karachi, who underwent successful surgical excision for a well-differentiated retroperitoneal liposarcoma and had no radiographic evidence of local recurrence at both 3 and 12-month follow-ups.
Keywords: Retroperitoneal liposarcoma, surgical excision, tumour recurrence, tumour grade.
Setting the boundaries and scope of practice for the two sister specialities of dentistry: operative dentistry-endodontics and prosthodontics
Authors: Farhan Raza Khan
Published: December 2023

Dental academia in Pakistan has recently achieved an important milestone. The name of Operative Dentistry speciality has been changed to Operative Dentistry & Endodontics (ODE). It was a much-needed change that was first felt about two decades ago. However, with the correction of name, there are certain challenges that this speciality has to manage now. These include improving the curriculum, setting up standards, and lastly, setting up its boundaries and scope of practice as some of its scope overlaps with a sister speciality called Prosthodontics. This overlapping of the boundaries of dental disciplines is a problem that is unique to Pakistan, India, and some East Asian countries where Operative Dentistry or Conservative Dentistry is combined with Endodontics. This paper aims to discuss the objective delineation of dental procedures and suggest a model of peaceful co-existence of sister dental specialities.
Keywords: Scope-of-practice regulation, Appointment, Credentialing, Group practice.
Editorial: The commons, the rarities
Authors: Geslin Benoît
Published: December 2023

Editorial: The commons, the rarities.
Variability of parameters of the COVID-19 epidemic process due to influence of regional social-hygienic factors
Authors: Zaitseva Nina V. , Kleyn Svetlana V. , Alekseev Vadim B. , Kiryanov Dmitry A. , Glukhikh Maxim V.
Published: December 2023

Introduction. Within the theory on self-regulation of parasitic systems, natural and social factors are considered not only the necessary condition for interaction between an infectious agent and susceptible organisms but they are also seen as regulators of phase transformations over the epidemic process. The COVID-19 epidemic process, if it conforms to postulates outlined in this theory, should be determined by influence of certain combination of environmental factors.
The purpose of the study. To establish priority social and hygienic environmental factors potent of modifying COVID-19 epidemic process on the RF territory.
Materials and methods. We applied correlation-regression and factor analysis to establish cause-effect relations between environmental factors and parameters of the COVID-19 epidemic process. Parameters of the COVID-19 epidemic process were identified based on the SIR+L compartment model and used as dependent variables. Overall, 263 factors were examined; they were conditionally divided into seven groups (anti-epidemic activities, environment, etc.).
Results. The study findings revealed several priority statistically significant factors. They include anti-epidemic activities (“population covered by vaccination” especially in older age groups (r = –0.67–(–)0.69)), levels of economic development on a given territory (gross regional product (r = –0.22)), socioeconomic wellbeing of population (households’ expenditures on food (r = 0.27)), lifestyle indicators (retail alcohol sales as per specific products (r = 0.21–0.38)), quality of the environment, workplace included (r = 0.11–0.22), urbanization (motorway density (r = 0.18)), weather and climatic factors (average monthly temperatures (r = 0.22), average monthly insolation (r = –0.25)) and others.
Limitations. The set of the examined priority factors and a period of their analysis can be considered limitations of the present study.
Conclusion. The obtained estimates as regards the priority environmental factors determining the COVID-19 epidemic process can be used when developing systemic strategic decisions on public health protection and securing its safety both in specific regions and the country as a whole.
Apoptosis in germ cell in vitro in middle-aged and older men with chronic prostatitis under exposure to reprotoxicants (by the example of benzene)
Authors: Dolgikh Oleg V. , Alekseev Vadim B. , Dianova Dina G. , Alikina Inga N. , Nikonoshina Natalya A.
Published: December 2023

Introduction. The issues of studying the causes and development mechanism of chronic prostatitis as the most important factor in the formation of male infertility are extremely relevant nowadays. Confirmed reprotoxicants including aromatic hydrocarbons inhibit spermatogenesis and lead to androgen deficiency.
Purpose: to identify the features of spermatozoa apoptosis in vitro in middle-aged and older men with chronic prostatitis under exposure to reprotoxicants (using benzene as an example).
Material and methods. A study of the ejaculate in thirty men with chronic prostatitis was conducted.
19 men were under 36 years old, 11 men were over 44 years old. Intracellular and membrane cell death markers (AnnexinV-FITC+PI–, AnnexinV-FITC+PI+, Bax, caspase-3) in semen samples were identified by flow cytometry. Seminal fluid samples without benzene were control; samples with the addition of 0.001 µ/ml of benzene were experimental. Spontaneous and benzene-induced samples were incubated for 72 hours at 37 °C.
Results. The in vitro system revealed that the addition of 0.001 µg/ml benzene to the ejaculate of men under 36 years of age reduces the content of AnnexinV-FITC+PI–-spermatozoa (p < 0.05). The content of CD95+- and AnnexinV-FITC+PI–-spermatozoa in the sperm of men over 44 years of age was significantly reduced against the background of an increase in Bax compared with the results of patients under 36 years of age (p < 0.05).
Limitations. The study limitations are the use of specific cellular material — gametes, as well as indicators
of cell differentiation clusters reflecting the cell death.
Conclusion. In vitro experiment verification features of sperm lethal program in men with chronic prostatitis revealed the signs of apoptosis inhibition associated with age and a chemical modifier — benzene. We revealed the signs of the violations in mitochondrial regulation and phosphatidylserine realization of programmed germ cell death in older men relative to young men were revealed. It is recommended to use the content of Bax, CD95+- and AnnexinV-FITC+PI–-spermatozoa in an ejaculate as the diagnostic predictors of sperm fertility disorders in men = with chronic prostatitis under benzene exposure.
Bazı Değişkenler Açısından Ölüm Kaygısının İncelenmesi
Authors: DAĞCI Abdullah
Published: December 2023

Çalışmanın amacı, ölüm kaygısını bazı değişkenler açısından incelemektir. 409 katılımcı ile gerçekleştirilen bu araştırmada, betimsel araştırma modeli ve rastgele örnekleme yöntemi kullanılmıştır. Ölüm kaygısını çok çeşitli değişkenler açısından ele alması ve ilk yetişkinlik dönemindeki bireyler üzerinde gerçekleştirilmesi bakımından önemli bir çalışmadır. Araştırmanın sonuçlarına göre cinsiyet, yaş, dini inancının hayatına etkisi ve beş vakit namaz kılma sıklığı açısından ölüm kaygısı puanlarında farklılaşmalara ulaşılmıştır. Buna göre katılımcıların genel ölüm kaygısı düzeyleri düşüktür. Erkeklerin ölüm kaygısı, kızlardan daha yüksektir. ‘24 yaş ve üzeri’ grubun ölüm kaygısı en yüksektir. Büyükşehirlerde yaşayan grubun ölüm kaygısı en yüksektir. Sosyo-ekonomik durumu ‘yüksek’ olanların ölüm kaygısı en yüksektir. İlahiyat Fakültesi’ndeki öğrencilerin ölüm kaygısı, diğerlerinden daha yüksektir. Kendisini ‘dindar’ olarak tanımlayanların ölüm kaygısı, ‘dindar değil’ diyenlerinkinden daha yüksektir. Ailesini ‘dindar’ olarak algılayanların ölüm kaygısı, ‘dindar değil’ diyenlerinkinden daha düşüktür. Dini inancının hayatına etkisini ‘düşük’ düzeyde olduğunu belirtenlerin ölüm kaygısı en yüksektir. Beş vakit namazı ‘hiçbir zaman’ kılmayanların ölüm kaygısı, diğer gruplardan daha yüksektir.
IMPLEMENTASI PROGRAM E-SAMSAT DALAM RANGKA MENINGKATKAN DAN MENYEDERHANAKAN PELAYANAN MASYARAKAT DI KANTOR UPT BAPENDA SIDOARJO
Authors: Kurniawan Bagus Ananda , Ismail Ismail , Alverdo Marchelino Joshua
Published: December 2023

This study aims to describe the implementation of the e-Samsat program in order to improve and simplify community services at the UPT Bappenda Sidoarjo office in supporting public services that are transparent in tax sector revenue. This study used a qualitative research method with a descriptive research type. The location of this research includes government institutions that have involvement with the implementation of E-Samsat, namely the Regional Revenue Agency of Sidoarjo Regency as the agency in charge of implementing it. Data collection techniques were carried out by in-depth interviews with informants, activity documentation, and the use of written documents. Furthermore, the data analysis technique is by means of data reduction, data presentation, and drawing conclusions. Through the results of research conducted by researchers using an implementation indicator from Edward III with a communication indicator that has gone well through a series of socialization processes and dissemination through social media and print media. Indicators of disposition/attitude, the staff is good enough in providing services to taxpayers. In the indicator the organizational structure has been going well with the governor's regulations governing tax payments using the online system. On the resource dimension, training was held to improve the quality of the performance of staff at the Sidoarjo Regency Regional Revenue Agency.Key Words: implementation, e-samsat, tax
PROSES PRODUKSI PROGRAM MLC BERJARINGAN DI LPP RRI MEULABOH
Authors: Zahira Cut Intan
Published: December 2023

Banyaknya media dan program-program yang bermunculan membuat kebutuhan masyarakat terhadap informasi menjadi meningkat, hal itu mendorong perusahaan berlomba menciptakan program yang menarik Morning Live Chat adalah salah satu program unggulan yang dijalankan oleh Radio Republik Indonesia, dan dibuat dengan versi ‘mini’ oleh RRI Meulaboh, RRI Banda Aceh, RRI Lhokseumawe, dan RRI Takengon yang tergabung dalam koordinator wilayah XVII Aceh. Penelitian ini bertujuan untuk menganalisis bagaimana proses manajemen yang dilakukan oleh RRI Meulaboh dalam melakukan pengelolaan program Morning Live Chat Berjaringan, yang diharapkan mampu mendukung keilmuan yang terkait dengan radio. Penelitian ini menggunakan metode kualitatif deskriptif dengan melihat fakta-fakta yang terkait proses manajemen yang dijalankan serta teknik pengumpulan data yang dilakukan yaitu observasi partisipasi, wawancara, dan studi pustaka. Proses manajemen dalam penelitian ini terkait dengan penerapan model fungsi komunikasi George R. Terry, yaitu perencanaan, pengorganisasian, pelaksanaan, dan pengawasan serta faktor-faktor yang mendukung dan menghambat proses pengelolaan program Morning Live Chat Berjaringan.Kata kunci: Manajemen Produksi, Program, Siaran, RRI
KEPEMIMPINAN RELIGIUS DALAM IMPLEMENTASI KEBIJAKAN PENUTUPAN TEMPAT HIBURAN (KARAOKE) (STUDI KASUS KEBIJAKAN WALIKOTA MENUTUP TEMPAT HIBURAN (KARAOKE) DI KOTA PROBOLINGGO)
Authors: Marwiyah Siti , Puspitarini Renny Candradewi , Solihin Muhammad Hindun
Published: December 2023

Leaders have a mandate to carry out their obligations in accordance with their position and position, and follow applicable regulations. Leadership is also related to the background of understanding of religion, so that in making policies accompanied by religious values. Thus, religious leadership is realized. A phenomenon related to the religious leadership model and policy is the phenomenon related to the license of entertainment venues. As in the city of Probolinggo, which also issued a policy on entertainment place licenses. issued Perda Number 9 of 2015 concerning the Arrangement, Supervision and Control of Entertainment Place Businesses. This is interesting to study, especially with the five-dimensional theory, including ideology; intellectual; public practice; private practice; religious experience. The results showed that the leadership of the Mayor of Probolinggo for the 2019-2024 period implemented a policy of closing karaoke places in Probolinggo City. The policy illustrates a religious leadership model. The point is that the mechanism for closing karaoke places applies the principles of democracy and is related to the understanding of religion by the Mayor of Probolinggo. And there is a violation of Regional Regulation Number 9 of 2015 concerning Arrangement, Supervision, and Control of Entertainment Places. This policy does not only benefit one religion, but for religious harmony. It is not only the Muslim community that thinks badly of karoke places, but other religions as well. There are even karoke venues located in public places that are still close to schools and places of worship. In addition, it was found that there is the provision of song accompaniment when karaoke, the dress of guests and employees is not polite, and there is the sale and purchase of alcoholic beverages.Keywords : religious leadership, policies, entertainment permits
PENGARUH BUDAYA KERJA 5R TERHADAP KINERJA PEGAWAI SMK NEGERI 4 KOTA PROBOLINGGO
Authors: Nawangsih Veronica Sri Astuti , Rahmadi Andhi Nur , Karmawati Wiwit Dwi
Published: December 2023

Budaya kerja adalah model kebiasaan dalam komunitas yang diwujudkan sebagai bentuk kinerja. Budaya kerja berhubungan dengan nilai yang dipahami dalam organisasi sebagai media antar pegawai yang mempengaruhi kinerja pegawai. Salah satu budaya kerja adalah budaya kerja 5R yakni ringkas, rapi, resik, rawat, dan rajin. Budaya kerja 5R juga tepat diterapkan di lingkungan sekolah, termasuk di SMK Negeri 4 Kota Probolinggo. Sekolah ini dikenal dengan kedisiplinan yang cukup tinggi. Hal ini menarik untuk diteliti, terkait pengaruh budaya kerja 5R pada kinerja pegawai pada lingkungan SMK Negeri 4 Kota Probolinggo. Riset ini bagian dari riset kuantitatif dengan deskriptif. Data dalam riset merupakan data primer dihimpun dari kuesioner yang dijawab oleh responden, yaitu pegawai SMKN 4 Kota Probolinggo sebanyak 88 orang. Hasil riset dan pembahasan menunjukkan variabel budaya kerja 5R memberikan pengaruh positif yang signifikan pada kinerja pegawai di SMKN 4 Kota Probolinggo.Kata kunci: budaya kerja; 5R; Kinerja Pegawai
Analisis Pemanfaatan Sp4n Lapor Untuk Meningkatkan E-governnment di Diskominsa Aceh Barat Daya
Authors: Santia Nova , Mauliansyah Fiandy
Published: December 2023

Layanan Aspirasi dan Pengaduan Masyarakat Online (LAPOR) atau dikenal juga dengan LAPOR SP4N adalah media komunikasi pengaduan pelayanan publik yang digunakan oleh Dinas Komunikasi, Informasi dan Rambu (Diskominsa) untuk meningkatkan e-government di Kabupaten Aceh Barat Daya. Kajian ini melihat SP4N LAPOR. Tujuan dari penelitian ini adalah untuk mengetahui bagaimana Diskominsa Aceh Barat Daya menggunakan website Sp4n Lapor untuk meningkatkan e-government, kesulitan dan permasalahan yang dihadapi selama implementasi website Sp4n Lapor, dan apakah saluran komunikasi website Sp4n Lapor telah beroperasi dengan baik. Penelitian ini menggunakan metodologi penelitian deskriptif kualitatif. Temuan peneliti dari penelitian ini menunjukkan bahwa penggunaan Sp4n Lapor untuk meningkatkan E-government di Kabupaten Aceh Barat Daya belum optimal karena kantor masih baru, infrastruktur belum memadai, sosialisasi kurang, masyarakat belum memahami mekanisme Sp4n Lapor dan website tampilan tidak menarik dan terkendala dalam sumber daya manusia, kebijakan dan anggaran.Kata Kunci :  E-government, pelayanan publik, dan Sp4n Lapor.
PENGUATAN SISTEM PRESIDENSIAL MELALUI PENERAPAN AMBANG BATAS PARLEMENTARY THRESHOLD
Authors: Fikri Sultoni , Firmansyah Muhammad , Sabina Vina
Published: December 2023

Penelitian ini bertujuan untuk mengkaji penguatan sistem presidensial melalui penerapan ambang batas parlemen dalam pemilu di indonesia. Penelitian ini menggunakan jenis penelitian hukum normatif.. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan perundang-undangan serta pendekatan konseptual. Hasil penelitian ini  menunjukkan pentingnya penerapan parliamentary threshold, dimana pembentukan suatu threshold sebenarnya merupakan upaya pemerintah dan DPR untuk merampingkan partai politik guna meningkatkan efektifitasnya dalam pemerintahan. Untuk mengkonsolidasikan partai politik dan meningkatkan stabilitas politik, yang pada akhirnya akan menawarkan kekuasaan, otoritas, dan martabat pemerintah, diperlukan ambang batas parlemen. dalam membentuk pemerintahan yang stabil adalah penerapan ambang batas parlemen. Di negara demokrasi ini, ambang batas parlemen adalah gagasan yang tepat untuk mengurangi jumlah partai politik. Ambang batas parlemen sekarang digunakan, tetapi dapat dikatakan bahwa itu tidak efisien karena lebih banyak partai politik yang memenuhi syarat untuk parlemen daripada lebih sedikit. Ini karena kompromi partai politik, bukan penelitian ilmiah, menentukan tingkat persentase yang digunakan. perhitungan persentase ambang batas parlemen perlu dilihat dari berbagai sudut, bukan hanya terletak pada jalan tengah yang tipis antara partai besar dan partai kecil. Selain itu, penggunaan ambang batas parlemen nasional dapat dipertimbangkan kembali agar penyederhanaan partai politik dapat terjadi secara nasional hingga ke daerah karena memperkuat pemerintah daerah sama pentingnya untuk membangun pemerintahan nasional yang stabil seperti memperkuat pemerintah pusat. Namun, karena setiap kepentingan daerah berbeda dan harus dipenuhi secara bertahap, penerapan ambang batas parlemen nasional tidak dapat dibagi secara seragam besaran persentasenya.Kata kunci : Ambang Batas, Parlemen, Partai Politik
KEMAMPUAN MEREGULASI EMOSI PADA REMAJA KORBAN PELECEHAN SEKSUAL DI KELURAHAN WANEA, KOTA MANADO
Authors: Tambanua Silvana Gita , Solang Deetje , Kaunang Sinta
Published: December 2023

Regulasi emosi merupakan kemampuan individu dalam mengatur dan menyesuaikan emosi yang dirasakan, meliputi pengaturan perasaan, reaksi fisiologis, cara berpikir, dan respon emosi, serta kemampuan untuk cepat menenangkan diri setelah kehilangan kendali atas emosi yang dirasakan, baik secara sadar maupun tidak sadar. Penelitian ini bertujuan untuk menyelidiki kemampuan regulasi emosi pada remaja yang menjadi korban pelecehan seksual. Penelitian ini menggunakan pendekatan kualitatif dengan studi kasus sebagai metode penelitian. Hasil penelitian menunjukkan bahwa subjek penelitian menunjukan emosi negatif yang dihasilkan oleh dampak pelecehan seksual yang dialami. Namun, subjek mampu mengatur emosinya dengan baik ketika menghadapi situasi yang memicu emosi negatif. Temuan ini menunjukkan bahwa remaja korban pelecehan seksual memiliki kemampuan yang baik dalam regulasi emosi.Kata kunci: regulasi emosi, remaja,pelecehan seksual
ANALISIS TERHADAP IMPLEMENTASI HUKUM DALAM PENGELOLAAN SAMPAH (LIMBAH) B3 DI KABUPATEN PIDIE
Authors: Qasthary Auzan , Suhaibah Suhaibah , Al Muttaqien Al Muttaqien
Published: December 2023

Pengelolaan limbah berbahaya dan beracun (B3) merupakan isu penting dalam upaya pelestarian lingkungan dan kesehatan masyarakat. Artikel ini bertujuan untuk menganalisis implementasi hukum dalam pengelolaan sampah B3 di Kabupaten Pidie. Kabupaten Pidie, sebagai salah satu daerah di Indonesia, menghadapi tantangan serius dalam mengelola sampah B3. Implementasi hukum yang efektif adalah kunci untuk mengurangi dampak negatif limbah B3 terhadap lingkungan dan kesehatan manusia. Artikel ini akan mengulas peraturan dan praktik pengelolaan sampah B3, mengidentifikasi kendala yang dihadapi dalam implementasinya, dan mengevaluasi dampak dari kebijakan yang telah ada.. Kata kunci: Implentasi Hukum; Pengelolaan; Sampah B3; Pidie
PENGARUH GAYA KEPEMIMPINAN DAN PROMOSI JABATAN TERHADAP KINERJA KARYAWAN PT. GLOBAL JET CARGO SURABAYA
Authors: Aoliya Muhammad Aan
Published: December 2023

This study aims to determine the simultaneous effect and partial work ability of employees which include leadership style, promotion on employee performance at PT Global Jet Cargo Surabaya and determine the leadership style variable that has a dominant influence on employee performance at PT Global Jet Cargo Surabaya. The sample in this study were employees at PT Global Jet Cargo Surabaya, namely 98 employees. This type of research is explanatory research (explanation), that is, if the data is the same, the researcher explains the causal relationship between variables through hypothesis testing. The sampling technique used in this study is non-probability sampling, namely the entire population is used as the research sample. Data analysis using the F test and t test. The conclusion from the research results can be seen that there is influence of leadership style and promotion both simultaneously and partially on the performance of employees at PT Global Jet Cargo. Leadership style variable has a dominant influence on employee performance at PT Global Jet Cargo.Keywords: leadership style, promotion employee performance
DAMPAK UNDANG – UNDANG KORUPSI DAN PENYALAHGUNAAN DANA PERPAJAKAN DIINDONESIA
Authors: Hutabarat Ela Suryani , Rasji Rasji
Published: December 2023

Penelitian ini bertujuan untuk mengeksplorasi dampak undang-undang korupsi dan penyalahgunaan dana perpajakan di Indonesia. Penelitian ini akan menganalisis pengaruh undang-undang ini terhadap pembangunan dan pertumbuhan ekonomi, kepercayaan investor, kesejahteraan masyarakat, dan pemerataan ekonomi di Indonesia. Selain itu, penelitian ini juga akan mengulas adanya hubungan antara tingkat korupsi dan penyalahgunaan dana perpajakan dengan ketimpangan sosial dan kesenjangan ekonomi di Indonesia. Penelitian ini akan melihat upaya pencegahan dan penanggulangan korupsi serta penyalahgunaan dana perpajakan yang telah dilakukan di Indonesia dan sejauh mana efektivitasnya. Hasil dari penelitian ini diharapkan dapat memberikan pemahaman yang lebih baik tentang dampak undang-undang korupsi dan penyalahgunaan dana perpajakan dan merekomendasikan langkah-langkah untuk memperbaiki situasi ini di Indonesia.Kata kunci : Korupsi, Ekonomi , pajak , undang – undang.
ANALISIS SOSIOCULTURAL DAN PENGGUNAAN BAHASA KEDUA DALAM MASYARAKAT (STUDI KASUS MAHASISWA BAHASA INGGRIS)
Authors: Khairunnisa Khairunnisa , H.M Yusuf Zakaria , Sagita Mustakim
Published: December 2023

Penelitian ini menjelaskan analisis sosiokultural dan penggunaan bahasa kedua dalam masyarakat, dengan fokus pada mahasiswa bahasa Inggris. Mahasiswa bahasa Inggris menghadapi lingkungan yang dinamis di mana bahasa kedua, yaitu bahasa Inggris, menjadi peran penting dalam kehidupan akademik dan sosial mereka. Studi ini mencoba untuk memahami dampak faktor-faktor sosiokultural pada penggunaan bahasa kedua mereka dalam konteks tersebut. Penelitian ini melibatkan analisis sosiokultural yang meliputi berbagai aspek, seperti konteks akademik, identitas linguistik, gaya komunikasi, perkembangan kemampuan bahasa, dan peran pendidik. Data dikumpulkan melalui wawancara, observasi, survei, dan analisis teks tertulis dari mahasiswa bahasa Inggris. Hasil penelitian menunjukkan bahwa pengaruh budaya asal, pengaruh lingkungan akademik, serta interaksi dengan dosen dan teman sebaya memiliki peran penting dalam penggunaan bahasa kedua mahasiswa. Terdapat juga variasi dalam penggunaan bahasa kedua, seperti diglossia dan code-switching, tergantung pada konteks social. Penelitian ini menyoroti pentingnya pengembangan identitas linguistik, peran pendidik, dan faktor-faktor sosial dalam penggunaan bahasa kedua mahasiswa bahasa Inggris. Hasil penelitian ini memiliki implikasi penting dalam perencanaan kurikulum dan strategi pengajaran bahasa kedua di lingkungan universitas. Sebagai hasilnya, penelitian ini membantu dalam memahami dinamika penggunaan bahasa kedua dalam masyarakat mahasiswa bahasa Inggris dan kontribusinya terhadap perkembangan mereka dalam pendidikan tinggi.Kata kunci: Analisis Sosiokultural; Lingkungan Akademik; Pengaruh Sosial; code-switching.