bluuebunny/crossref_metadata_2025 huggingface dataset:
ТЕОРЕТИЧНА ПІДГОТОВКА КУРСАНТІВ ЯК ФАКТОР, ЩО ВПЛИВАЄ НА РІВЕНЬ СКЛАДНИКІВ СПЕЦІАЛЬНОЇ ФІЗИЧНОЇ ПІДГОТОВЛЕНОСТІ
Authors: Соловей О. М. , Пожидаєв М. Ю. , Дищенко Д. В. , Вознюк К. Г. , Петренко С. П. , Анісімов Д. О.
Published: April 2022

Нині основною складовою частиною професійної діяльності працівників правоохоронних органів є високий рівень компетентності і рівень спеціальної фізичної підготовленості. Незважаючи на це, рівень теоретичної підготовки курсантів і здобувачів вищої освіти та їхні теоретичні знання не завжди відповідають вимогам, які сприяють підвищенню мотивації до занять зі спеціальної фізичної підготовки і вдосконаленню їх рівня. Тому проблемою нашого дослідження є визначити рівень теоретичної підготовки курсантів та її вплив на розвиток складників спеціальної фізичної підготовки протягом навчального процесу. Мета – визначити вплив теоретичної підготовки курсантів на їх рівень складників спеціальної фізичної підготовленості під час навчального процесу. Матеріал і методи: аналіз та узагальнення науково-методичної літератури та нормативних документів, анкетування, педагогічне спостереження, методи тестування спеціальної фізичної підготовленості, послідовний педагогічний експеримент; методи математичної статистики. Стимулюючими факторами успішного навчання в університеті є оволодіння професією (72,6 %), набуття знань (70,3 %), наявність бажання навчатися (93,4 %). Отримують задоволення від дисципліни «Спеціальна фізична підготовка» 28,3 %, мають бажання займатися додатково фізичними вправами 58,1 %. Із форми заняття обрали лекції в поєднанні з практичними заняттями 89,2 %, лекції в поєднанні із самостійною роботою – 60,3 %, лекції в поєднанні із семінарськими заняттями і консультаціями –61,8 %. 55,0 % задоволені змістом лекцій і практичних занять, 31,6 % достатньо зрозумілі поняття і терміни під час лекцій, 13,3 % відчували інтерес до проблем, що розглядалися під час лекції. 19,1 % вважають рівень власної підготовленості високим, 41,6 % – середнім і 34,4 % – нижчим за середній. Достовірно (р<0,05) покращились показники швидкісно-силових здібностей (на 3,1%), спритності (на 3,2 %), сили (на 25,4 %) та витривалості (на 3,6 %). Професійні мотивації першокурсників («оволодіння професією», «отримання диплома», «набуття знань») прямо пов’язані з формуванням професійних вмінь та навичок та набуттям теоретичних знань із дисципліни «Спеціальна фізична підготовка». Набуті теоретичні знання відіграють важливу роль у підвищенні рівня спеціальної фізичної підготовленості курсантів і здобувачів.
ЗАСОБИ ФІЗИЧНОЇ ТЕРАПІЇ ДЛЯ ЛІКУВАННЯ НАДЛИШКОВОЇ ВАГИ У ДІВЧАТ 19-20 РОКІВ
Authors: Сергата Н. С. , Халік Є. Ю.
Published: April 2022

У статті визначена хвороба, яка викликана надмірним харчуванням. У світі збільшилося число людей, які страждають від надлишкової ваги. Це одна з центральних проблем сучасної медицини та реабілітації. Визначено, що чим більше маса тіла, тим коротшою є середня тривалість життя, тим більша ймовірність розвитку таких важких захворювань, як цукровий діабет, атеросклероз, ішемічна хвороба серця і багато інших недуг, які ведуть до зниження і втрати працездатності в активному творчому віці. Зазначено, що в останні роки розроблені і впроваджені в клінічну практику багато методів дослідження, які дають змогу рекомендувати нові, більш досконалі методи та засоби фізичної терапії. Розробляються ефективні комплекси фізіотерапевтичних вправ, проводяться різні методики лікувального масажу, застосовується дієтотерапія, використовують рухові засоби фізичної терапії (підбирається необхідне навантаження за допомогою таких видів рухової активності, як скандинавська хода, аквааеробіка) та багато іншого. Визначено, що для профілактики та лікування надлишкової ваги для дівчат 19-20 років найбільш ефективними є регулярні заняття фізіотерапевтичним вправами, скандинавською ходою, аквааеробікою, проведення лікувального масажу та виконання рекомендацій із лікувального харчування. У роботі розкриті основні методи дослідження, а саме: аналіз засобів та методів фізичної терапії, метод анкетування; антропометричні вимірювання; оцінка функціонального стану кардіореспіраторної системи; педагогічний експеримент; методи математичної статистики. Наведені засоби фізичної терапії для лікування та профілактики надмірної ваги є одним із варіантів підходу до проблеми зменшення надмірної ваги. Створені з метою надання допомоги людям, які страждають від надмірної ваги, ці засоби дозволяють не тільки нормалізувати обмін речовин, а й попереджати можливі патологічні стани з боку різних систем організму.
ПОЄДНАННЯ ІГРОВОГО, ЗМАГАЛЬНОГО ТА КОМУНІКАТИВНОГО МЕТОДІВ НАВЧАННЯ ГРІ У ПРОЦЕСІ СПОРТИВНОГО ВІДБОРУ ЮНИХ ФУТБОЛІСТІВ
Authors: Дулібський А. В. , Зьомко О. В. , Дулібський А. А.
Published: April 2022

У теоретико-дослідницькій роботі зроблена спроба ліквідувати певні прогалини в теорії та практиці детального вивчення проблем спортивного відбору та селекції юних футболістів на основі використання сучасних різногалузевих методів навчання грі у футбол. Сучасний професійний футбол висуває виключно різноманітні та надвисокі вимоги щодо рухових якостей, здоров’я, психо-інтелектуальних можливостей спортсменів. Рівень підготовленості та здібностей юних футболістів, які в майбутньому можуть відбутися як видатні особистості спорту, визначається найширшим комплексом певних рухових якостей, техніко-тактичних і тактико-стратегічних задатків і здібностей, психічних та особистісних властивостей. Метою роботи було вивчення змісту спортивного відбору на основі використання ігрового, змагального та комунікативного методів навчання грі у футбол на початкових етапах спортивної підготовки і спеціалізованого навчання. У процесі початкового спортивного відбору застосовувалися прості педагогічні тестування для оцінки рухових здібностей юних футболістів. Перевага надавалася тестам, які характеризують рівень розвитку рухових якостей гравців, зумовлених, передовсім, вродженими задатками, і особливо тим, які давали змогу оцінити швидкісні якості, координаційні здібності, психофізичну та розумову витривалість при аеробних і анаеробних змагально-ігрових навантаженнях. Рівень розвитку координаційних здібностей визначався якістю виконання складних і складно-координаційних вправ у процесі їх вивчення та вдосконалення. Оцінювання проводилося залежно від амплітуди ігрових рухів, дотримання структурно-ритмічного малюнку вправи, вміння швидко змінювати темп і ритм рухів відповідно до ігрових завдань. Загалом у дослідженні взяли участь 908 юних футболістів – учнів спеціалізованих спортивних шкіл і академій, віком від 7 до 10 років (основні та додаткові (т.зв. «прихідні») групи). Юні футболісти та їхні батьки незгоди з участю в наукових дослідженнях не виявляли, про що свідчать підписані письмові згоди на участь дітей в експериментальних заходах, де були задіяні учні спортивних шкіл і академій. Проаналізовані проблеми навчання, виховання, тренування, вдосконалення і розвитку повноцінного футбольного резерву торкаються найширшої низки питань організаційного, інфраструктурного, методичного і науково-практичного характеру. Вони пов’язані з проблемою продуманого управління системою багаторічного навчання і спортивної підготовки юних футболістів.
ОСОБЛИВОСТІ ВПЛИВУ НАВЧАЛЬНО-ТРЕНУВАЛЬНОГО ПРОЦЕСУ НА ФУНКЦІОНАЛЬНІ ПОКАЗНИКИ ЮНИХ СПОРТСМЕНІВ З БАДМІНТОНУ
Authors: Коваленко Ю. О. , Тищенко В. О. , Товстоп’ятко Ф. Ф. , Блізніченко В. В.
Published: April 2022

У статті наведено результати досліджень проблеми особливостей впливу змісту навчально-тренувального процесу на функціональну підготовленість юних бадмінтоністок. У результаті наукового пошуку виявлено брак досліджень у напрямі вивчення показників, що характеризують зміни функціонального стану серцево-судинної та дихальної систем юних спортсменів. Наукові роботи переважно присвячені дослідженням технічної та фізичної підготовленості бадмінтоністів. З’ясовано, що вирішальними для успіху в цьому виді спорту є такі рухові здібності, як швидкість реакції, швидкість одиночного руху, швидкісно-силові здібності, гнучкість, загальна та спеціальна витривалість. Отже, діапазон засобів і методів впливу є досить широким і складним у поєднанні. Тож під час планування тренувальних навантажень необхідно враховувати, з одного боку, забезпечення всебічного розвитку фізичних якостей і функціональних можливостей організму, а з іншого – формування техніки. Було вивчено вплив методики підготовки юних бадмінтоністів на показники, що є інформативними під час оцінювання діяльності кардіо-респіраторного блока спортсменів, зокрема з боку серцево-судинної системи – систолічний та діастолічний артеріальний тиск, артеріальний тиск середній, хвилинний об’єм кровообігу, систолічний об’єм кровообігу, індекс Робінсона, адаптаційний потенціал, коефіцієнт економічності кровообігу; з боку дихальної системи – проби Штанге-Генчі, життєва ємність легень, частота дихання, хвилинний об’єм дихання, максимальна вентиляція легень. Експериментальним шляхом підтверджено ефективність розробленої методики побудови навчально-тренувального процесу дівчат 13–14 років. Наприкінці дослідження значно покращилися показники систолічного об’єму та коефіцієнт економічності кровообігу, життєвої ємності легень, показники проб Штанге-Генчі, частоти дихання та максимальної вентиляції легень. Підтверджено ефективність застосування в методиці навчання бадмінтоністів на етапі спеціалізованої базової підготовки поєднання кардіотренувань з силовими, швидкісно-силовими та швидкісними вправами із використанням комбінації занять 2 на 3 (2-денні з акцентом на вдосконалення аеробних здібностей помірної інтенсивності та 3-денні з акцентом на вдосконалення силових, швидкісних та швидкісно-силових здібностей).
A ELABORAÇÃO DE MODELOS DIGITAIS DE ELEVAÇÃO COMO SUPORTE PARA IDENTIFICAÇÃO DE ÁREAS DE RE-EXISTÊNCIA DA PRODUÇÃO FAMILIAR DE BASE AGROECOLÓGICA NA REGIÃO DA MATA SUL DE PERNAMBUCO
Authors: Brasileiro Robson Soares
Published: April 2022

Este artigo procura investigar o desenvolvimento de iniciativas agroecológicas em região de predominância do setor sucro-energético na Zona da Mata Sul de Pernambuco. Através de uma perspectiva geográfica, procura-se analisar a trajetória e os obstáculos que dificultam a construção de territorialidades alternativas para a agricultura familiar de base agroecológica. As unidades de produção integradas na região em apreço são fortalecidas mediante processos de intercâmbios e articulação entre sujeitos sociais (pessoas) e atores sociais (instituições) viabilizando estratégias de inovação ao mesmo tempo em que revalorizam saberes tradicionais e uma relação mais harmoniosa entre os sistemas de produção agrícola e a natureza. Os territórios da agricultura familiar de base agroecológica são espaços conectados em várias escalas territoriais e quase imperceptíveis na imensidão do “deserto verde da cana-de-açúcar” na Mata Sul, constituem-se como uma forma de contestação da produção familiar perante o capital hegemônico, materializando-se enquanto um processo de “re-existência”, isto é, novas estratégias territorializantes dos sujeitos e atores sociais aqui estudados.
DEGRADAÇÃO AMBIENTAL EM GILBUÉS-PI: BASES CONCEITUAIS, CONDICIONANTES GEOAMBIENTAIS E IMPACTOS NA PAISAGEM
Authors: Silva Ivamauro Ailton de Sousa
Published: April 2022

As diferentes manifestações do clima e sua interação com outros elementos físicos como a formação geológica, o relevo, os solos, a cobertura vegetal e a ação antropogênica, interferem na maneira pela qual o meio ambiente e a sociedade obtêm os seus mais diversificados processos. O propósito e o foco central do artigo é abordar um panorama que enfatiza questões pertinentes à amplitude conceitual, os condicionantes geoambientais que influenciam o processo de degradação ambiental em Gilbués-Piauí. Considerado oficialmente como um “núcleo de desertificação”, Gilbués, apresenta intensa morfogênese natural e teve historicamente, três ciclos econômicos: a pecuária extensiva, a mineração de diamantes e atualmente a agricultura mecanizada. A pesquisa foi elaborada com base na pesquisa bibliográfica, elaboração de gráficos de pluviosidade, mapas temáticos construídos a partir de técnicas de sensoriamento remoto e geoprocessamento e registros fotográficos que destaca os aspectos físicos. Por meio da compreensão das condições ambientais e socioeconômicas da área de estudo, foi fundamental para identificar e elucidar os condicionantes de maior expressividade na degradação ambiental, bem como as vicissitudes climáticas (distribuição e intensidade das chuvas), litologia (arenitos e rochas sedimentares) suscetibilidade dos solos (arenosos), influência da topografia do terreno (comprimento da rampa/vertente), cobertura vegetal (ausência) e ação antropogênica (uso e ocupação do solo). Destarte, a região apresenta suscetibilidade natural à ocorrência e expansão do processo de degradação ambiental em Gilbués-PI, exercendo influência na configuração da paisagem do sudoeste piauiense
O ESTUDO DA NATUREZA NA GEOGRAFIA FÍSICA EM UMA PERSPECTIVA GEOSSISTÊMICA
Authors: Oliveira de Souza Júlio César , De Barros Corrêa Antônio Carlos
Published: April 2022

O estudo da natureza pela geografia no âmbito acadêmico tem a preocupação de desvelar os mecanismos que regem o funcionamento do meio natural e como os seus componentes interagem. Dentre as teorias geradas pela geografia na perspectiva da conexão entre as partes de um todo, a noção de análise integrada trazida pela teoria geral dos sistemas de Bertalanffy (1975) fora adaptada por Sotchava (1977) na perspectiva de agregar os elementos componentes do meio natural e o fator humano e assim, unidades de paisagem que guardam certa interação entre seus componentes passam a denominar-se de geossistema e podem ser avaliadas dentro desta concepção. Este artigo objetiva trazer algumas considerações de ordem teórica, acerca da aplicação da teoria dos geossistemas e sua efetividade à análise da natureza no âmbito da geografia.
INDICADORES MORFOMÉTRICOS COMO SUBSIDIO AO PLANEJAMENTO AMBIENTAL EM UM SETOR DO MÉDIO CURSO DA BACIA HIDROGRÁFICA DO RIO PACOTI- CE.
Authors: Queiroz Pedro Henrique , Silva Juliana Maria O , Sales Marta Celina L.
Published: April 2022

O rio Pacoti tem um curso longitudinal de cerca de 112,5 Km com uma área aproximada de 1.257 km² estando suas nascentes localizadas, na vertente setentrional do Maciço de Baturité, em nível altimétrico entre 700m e 900m, abrangendo os municípios de Pacoti e Guaramiranga, na Latitude de S 4º 12’ e Longitude de W 38º 54’ e sua foz localiza-se no município de Aquiraz na faixa costeira delimitada pelas coordenadas geográficas S 3° 49’ 05’’e W 38° 23’ 28’’. O rio banha os municípios de Pacoti, Redenção, Acarape, Pacajus, Guaiúba, Horizonte, Itaitinga, Fortaleza, Eusébio e Aquiraz.O recorte espacial de análise trata-se de um trecho do médio curso da bacia hidrográfica do rio Pacoti, inserido entre as coordenadas geográficas UTM 513283/9547103 e 543283/9523103, abrangendo aproximadamente 247,6km² e  inserida maior parte  nos municípios de Redenção e Acarape, sendo o acesso realizado através das rodovias CE- 060, BR-116 e CE-354. Visando compreender melhor a dinâmica hidrológica local, foi realizada a análise morfométrica, que fornece importantes indicadores para a compreensão dos recursos hídricos que serão utilizados para a viabilização de um desenvolvimento sustentável a partir das potencialidades dos recursos naturais existentes na bacia hidrográfica do rio Pacoti. Foram determinados os seguintes parâmetros: Hierarquia Fluvial, Coeficiente de Manutenção (Cm), Extensão do Percurso Superficial (Eps), Densidade de Drenagem (Dd), Densidade de rios (Dh), Índice de Circularidade (Ic), Coeficiente de Compacidade (Kc) e o Índice de Sinuosidade (Is). A partir da análise do uso da terra referente a 1988 e 2009, foi possível perceber as transformações pelo qual esse setor da bacia passou nos últimos 20 anos, bem como os agentes causadores de impactos ambientais na área.
TRABALHO, EDUCAÇÃO E CAPITAL: É POSSÍVEL UMA EDUCAÇÃO MAIS HUMANIZADORA?
Authors: Dos Santos Dionys Morais
Published: April 2022

Este estudo vem reforçar a necessidade de levar, à sociedade, conhecimentos acerca de uma realidade imposta e falseada por discursos políticos estatais que legitimam os interesses do grande Capital e que tem na escola seu lócus de reprodução. Por meio de uma revisão bibliográfica que enfatiza as relações estabelecidas entre Educação e Capital, constatou-se que através de um processo de internalização do discurso ideológico, os ideários da flexibilidade e da empregabilidade atuam, explicitamente, como "formadores" de mão de obra alienada, ordeira e adestrada para atender às exigências do novo modelo de produção. A escola, nesse contexto, não deve ser entendida como a multiplicadora do Saber ou mera reprodutora de conhecimentos institucionalizados, mas como instituição pública que atende aos interesses do Capital. Desta forma, fez-se necessário uma investigação teórica capaz de nos conduzir a uma compreensão das principais bases que sustentaram um modelo educacional dominante e de que forma autores que versam sobre esse tema colocam formas de superação dessa estrutura.
CHANGES IN BASIC BLOOD SERUM ELECTROLYTES IN MEN UNDER 60 YEARS OLD WITH MYOCARDIAL INFARCTION, COMPLICATED BY ACUTE KIDNEY INJURY
Authors: V.A. Reiza , A.V. Golikov , B.B. Tassybayev , A.V. Gordienko
Published: April 2022

Abstract. Relevance. Acute kidney injury during myocardial infarction worsens the prognosis. At the same time, changes in electrolyte metabolism have been studied only in cases of severe lesions. And most of the data were obtained for patients over 60 years old.
Aim. To evaluate the features of changes in serum potassium, sodium, calcium, and chlorides in men under 60 years old with myocardial infarction complicated by acute kidney injury to improve prevention and outcomes.
Material and methods. The study included men 19-60 years old with type I myocardial infarction. The patients were divided into two age-comparable groups: I - study group, with acute kidney injury - 25 patients; II - control, without it - 168 patients. A comparative analysis of serum sodium, potassium, calcium and chloride concentration in the first 48 hours (1) and at the end of the third week of the disease (2), their dynamics, analysis of their impact on the risk of acute kidney injury (ANOVA) were performed.
Results. The study group differed from the control in high levels of sodium (143.3 ± 3.4 and 140.3 ± 4.5 (mmol/l); respectively; p = 0.004) and chlorides (104.6 ± 2.7 and 102.8 ± 3.5 (mmol/l); p = 0.047) at the end of the third week of the disease. The concentrations of the studied electrolytes increased at the second observation point in both groups of patients. The main markers of the acute kidney injury risk development in the first hours of myocardial infarction were: potassium levels < 4.75 mmol/l (absolute risk: 17.2%; p = 0.003), sodium ≥ 140 mmol/l (absolute risk: 18.2%; relative - 3.64; p = 0.01), chlorides ≥ 104 mmol/l (absolute risk: 22.6%; relative - 3.67; p = 0.02).
Conclusions. Men under 60 years old with acute kidney injury in myocardial infarction are characterized by low levels of potassium (<4.75 mmol/l) as well as higher levels of sodium (≥140 mmol/l) and chloride (≥104 mmol/l) serum in the first hours of IM. The listed above values should be used in the formation of the high-risk groups for the acute kidney injury development, as well as for prognostic modeling.
ANNUAL OUTCOMES OF ACUTE MYOCARDIAL INFARCTION COMBINED WITH TYPE 2 DIABETES MELLITUS
Authors: A.A. Tolmacheva , N.G. Lozhkina
Published: April 2022

Abstract. Relevance. The combination of acute myocardial infarction (AMI) and type 2 diabetes mellitus (DM2) entails early disability and mortality of the population, including among people of working age. The study of long-term outcomes of AMI in patients with type 2 diabetes is necessary to improve secondary prevention programs and reduce cardiovascular mortality.
Aim of the study. To evaluate the prognosis of myocardial infarction in combination with type 2 diabetes mellitus for 1 year.
Material and methods. He main group consisted of 115 patients with AMI and DM 2 (55 men and 60 women, the average age of patients was 63,2±5,3 years, men 62,3±5,5 years, women 64,3±4,9 years). The comparison group included 116 patients with AMI without concomitant DM 2 (in the comparison group 60 men, 56 women (mean age of patients 63,6±5,4 years, men 62,1±4,2 years, women 65,2±5,7 years). 12 months after the inclusion of patients in the study, an assessment of "endpoints" was carried out. Statistical data analysis was carried out using the modules of the SPSS Statistics 23.0 program.
Results. It was revealed that a history of type 2 diabetes increases the risk of cardiovascular death by 7.9 times (OR 7,929, 95% CI 1,758-35,758, p=0,002), 2.1 times (OR 2,138, 95% CI 1,050- 4,353, p= 0,034) the risk of repeated hospitalizations for myocardial ischemia. The annual unfavorable prognosis of AMI is affected by: a history of coronary artery disease (OR 5,653 CI 2,114- 5,114, p≤ 0,001); CHF II-IV FC according to NYHA (OR 4,316 CI 0,916-20,330, p= 0,048); multivessel coronary lesion (OR 4,759 CI 1,018-22,248, p= 0,032); anterior localization of AMI (OR 3,646 CI 1,630-8,156, p=0,01); brachiocephalic artery stenosis (OR 4,278 CI 1,042- 17,559, p=0,031); stage 3-4 chronic kidney disease (OR 6,406 CI 2,589- 15,852, p≤0,01); obesity (OR 2,368 CI 1,086- 5,164, p= 0,029).
Conclusion. The ideas about the annual outcomes of AMI in combination with type 2 diabetes in patients treated with modern methods of reperfusion therapy have been expanded.
THE ROLE OF RECOGNIZING RESPONSIBILITY FOR YOUR HEALTH AS A SOCIAL DETERMINANT OF HEALTH IN OLDER AGE GROUPS
Authors: S.N. Cherkasov , A.V. Fedyaeva , V.N. Avsadzhanishvili , A.L. Gorbunov
Published: April 2022

Abstract: The aim of the study was to assess the prevalence of recognition of responsibility for one's health in older age groups. Materials and research methods. An anonymous questionnaire was conducted for 1045 people of both sexes aged 60 years and older living in the metropolis (Moscow). The average age of the study group was 71.08 ± 1.3 years, men in the sample were 36%, women 64% respectively. Results of the study. The highest proportion of men and women of the older age groups who recognize responsibility for their health is observed in the age group 60–64, with an increase in age, the proportion that places primary responsibility for the state of health on the state and health systems, that is, taking a passive position, increases. Significant gender differences are not identified, but women are generally more responsible for their health, less often shifting responsibility to the state and the health system. The level of education has an impact on the fact that there is a decrease in the proportion of people who recognize the fact of responsibility for their health, in terms of increasing the age by 5 years, at which there is a decrease.
INVESTIGATION OF CONTENT OF BIOLOGICALLY ACTIVITY COMPOUNDS OF AERIAL PART OF CHENOPODIUM ALBUM L. PLANTING IN REPUBLIC BURYATIA
Authors: M.S. Bardakhanova
Published: April 2022

Abstract: In present study, the results are researching the chemical compounds of the aerial part of Chenopodium album L. growing on the territory the Republic of Buryatia. A study was conducted the qualitative composition and quantitative content of flavonoids in the flowering stage of vegetation of, the quantitative content of ascorbic acid, and the amount of phytoecdysteroids in three vegetation period: the vegetation stage, the flowering stage, the fruiting stage for the major component of 20-hydroxyecdysone.
The qualitative composition of flavonoids Ch. album is the major component quercetin. Because quantitative content of flavonoids is making in terms of quercetin. The results of quantitative content are: in water extraction - 3.38%; in water-alcohol extraction: 5.18% - 40%, 5.28 - 70%, 4.44 - 95% in terms of absolutely dry raw materials, confidence interval 0.5. The greatest content of flavonoids is extracted with ethyl alcohol 70%. Content of ascorbic acid in the aerial part Ch. album was 23.87 mg per 100g., confidence interval 0.8.
The content of 20-hydroxyectizone is equal to 28 mg/g – the vegetation stage, 18 mg/g – flowering stage, 32 mg/g – fruiting stage. The greatest content of 20-hydroxyectizone were at the period of fruiting.
For the first time, investigated the content of ascorbic acid and of 20-hydroxyecdysone Ch. album from Buryatia.
A CASE OF SUCCESSFUL SURGICAL TREATMENT OF CORONARY ARTERY DISEASE WITH COMPLICATED POSTINFARCTION LEFT VENTRICULAR ANEURYSM
Authors: A.K. Zhalilov , A.S. Vishhipanov , Кh.S. Namozov
Published: April 2022

Abstract: Left ventricular aneurysms (LV aneurysms) are a common complication of acute myocardial infarction, in which the scar area of the left ventricular tissue gradually becomes thinner and dyskinetic. The aneurysm often consumes some of the left ventricular ejection, which ultimately leads to chronic heart failure, which may be refractory to drug therapy and require surgical repair with apical left ventricular aneurysm. Surgical techniques to restore the volume and shape of the left ventricle have evolved over the years. Surgical treatment of LV aneurysms was first performed by Charles Bailey [1]. Denton Cooley and colleagues [2] reported about the first resection in cardiopulmonary bypass. Over the next decades, in addition to traditional linear plastics, new methods of patch remodeling were developed and published in order to improve the results [3,6]. Although aneurysmectomy has been performed for almost five decades, the most appropriate surgical approach for a patient with LV dyskinetic aneurysm is still controversial. Myocardial ischemia leads to the loss of a part of the viable myocardium and causes a whole complex of morphological and functional disorders of the heart. The latter, as a rule, are based on the processes of cicatricial transformation of the left ventricular myocardium, leading to disproportionate stretching and thinning of its walls, dilatation and spherization of its cavity, which in turn is the cause of pathological changes in intraventricular spatial-geometric relationships, which together define the concept ischemic remodeling. The formation of a left ventricular aneurysm often occurs with acute occlusion of the LAD, which leads to the development of severe angina pectoris and a clinic of severe heart failure. Plasty of the left ventricular aneurysm according to Dor and modified by Academician L.A. Bokeria - circular narrowing of the orifice of the aneurysmal sac and endoventriculoplasty of the left ventricle with a synthetic patch, in postinfarction LV aneurysms, has proven its safety and effectiveness. This operation is devoid of the disadvantages inherent in other methods of left ventricular reconstruction. It allows for a complete resection of the aneurysm with minimal risk of critical reduction of the LV cavity. Reconstruction of the left ventricular aneurysm and myocardial revascularization leads to a significant improvement in pumping function and a decrease in symptoms of heart failure. As a clinical example, a case of successful surgical treatment of a giant left ventricular aneurysm is presented.
ON THE ISSUE OF SHORTCOMINGS IN THE REGULATORY REGULATION OF PRESCRIBING, ACCOUNTING AND RETURN OF NARCOTIC DRUGS AND PSYCHOTROPIC SUBSTANCES
Authors: M.F. Mikaelyan , M.M. Khachatryan
Published: April 2022

Abstract: The turnover of narcotic drugs and psychotropic substances in healthcare is regulated by a large volume of regulations that act as legal sources when working with these substances. But, despite the progressive changes in recent years to regulate relations in this area, there are still some shortcomings. In addition, in the near future, it is expected to cancel a number of documents related to this area of activity within the framework of the "normative guillotine", their new projects have been published, in which, unfortunately, there are also shortcomings. At the same time, the presence of some contradictions and shortcomings leads to an ambiguous understanding of certain points of legal norms. At the same time, the main burden and responsibility lies on the administrative shoulders of medical organizations, therefore, when developing legislative norms, first of all, it is necessary to focus on this category. The activities of medical organizations related to the turnover of narcotic drugs and psychotropic substances are carried out according to certain rules established in accordance with the regulatory acts of the Russian Federation. The study of individual acts showed that there are a number of unresolved issues in the provision of assistance to incurable patients, which cause discussion among practitioners engaged in this field. The study was conducted on the basis of a content analysis of the currently relevant information base regulating the turnover of these substances on the territory of the Russian Federation. Some shortcomings of regulatory regulation in terms of keeping records of prescription forms and the return of narcotic drugs have been identified. Based on the results of the analysis, it is proposed to take these comments into account in the draft documents being developed within the framework of the "normative guillotine". It is shown that a more responsible approach is needed to work with these substances, including when prescribing them, accounting for prescription forms and registration of journals, since the volumes of the regulatory array contribute to an increase in the "field" of legal collisions. In addition, there is a responsibility for violating the rules of accounting and storage of prescription forms, not only managers, but also employees who are responsible for accounting and storing them; attending physicians who receive forms for prescribing these drugs to patients.
PROCESS QUALITY MANAGEMENT OF PHARMACEUTICAL SERVICES
Authors: A.A. Klimenkova , A.A. Skripko , L.N. Geller , L.A. Gravchenko , E.O. Rodionov
Published: April 2022

Abstract: Currently, the result of the activity of any retail pharmaceutical organization is very consumer-oriented and aimed at the quality of the provision of pharmaceutical services, which subsequently has a positive effect on the level of provision of pharmaceutical care. Therefore, improving the quality of pharmaceutical services is relevant and significant in the implementation of pharmaceutical activities. The implementation of this approach is possible only with a systemic impact on the entire activities of the organization from strategic planning to the sale of high-quality finished products to the consumer. This circumstance necessitates the standardization of all production activities of a retail pharmaceutical organization from the standpoint of quality management systems.
Aim. Substantiation and development of methodological recommendations on the use of a process-oriented approach to improve the quality of pharmaceutical services provided to the population.
Matherials and methods. The authors used data from the content analysis of scientific literature and current regulatory documents regulating aspects of the functioning of the quality management system in a retail pharmaceutical organization
Results. This study is devoted to the rationale for the application of a process-oriented management structure in the activities of retail pharmaceutical organizations. The article presents a model of the functioning of a system of production processes in a pharmacy, as well as a scheme for the transformation of a pharmaceutical product and the production of pharmaceutical services in the course of such activities.
Conclusion. The methodological recommendations developed by the authors on the unification of the technology of performing basic production processes and synchronization of management, in the format of the successful functioning of the quality management system of a retail pharmaceutical organization, will contribute not only to improving the level of services provided, but also improve the quality of pharmaceutical care to the population.
ETIOLOGY AND PATHOGENESIS OF TEMPOROMANDIBULAR JOINT DISEASES
Authors: E.G. Borisova , A.P. Duda , E.S. Poplavskii , A.A. Serikov
Published: April 2022

Abstract: The article aims to review the available scientific literature on the topic: "Etiological factors and pathogenesis of diseases of the temporomandibular joint", in order to draw attention to the problems of classifying these pathologies from the standpoint of the cause of their occurrence. The particular relevance of the topic given by the fact that any dentist, regardless of his specialization, can face this problem. Studies carried out both in our and in foreign countries, despite a significant scatter of results, assert a wide epidemiological prevalence of TMJ pathology in all population groups. In addition, according to some authors, TMJ pathology in terms of frequency of occurrence among lesions of the tooth-jaw system is second only to periodontal diseases and caries. The vastness of TMJ pathologies is due to the structure, anatomical and topographic features, functional and morphological changes that occur during life, the presence of concomitant pathologies, as well as disturbances in the balance of the main components of the tooth-jaw system: muscles and the joints themselves. The factors that provoke TMJ diseases divided into several groups: occlusive; muscle; articular, traumatic and iatrogenic, errors in orthopedic and orthodontic treatment, overbite during treatment; systemic and hereditary - hypermobility or hyper-relaxation of the joint, dysplasia of connective tissue and, finally, hormonal, each of which considered both independently and in combination with others. The presence of extensive etiological factors makes the correct diagnosis and treatment difficult. Often, the incorrectness of the treatment of such patients consists in the elimination of individual symptoms instead of a complex effect on the causes, pathogenesis and symptoms of the disease. A thorough analysis of provoking factors, as well as the development of a classification reflecting the etiology of TMJ diseases will facilitate the treatment of pathology in the near future.
SIGNALING ROLE OF REACTIVE OXYGEN SPECIES IN PLATELETS
Authors: T.A. Prokhorova , O.K. Savushkina , I.S. Boksha , E.B. Tereshkina , E.A. Vorobyeva , G.Sh. Burbaeva
Published: April 2022

Abstract: Review. Reactive oxygen species are formed as a result of redox reactions and are involved in signaling associated with cell growth, differentiation, and death. Platelets are both a source and a target of reactive oxygen species. The review regards the molecular mechanisms of the reactive oxygen species formation under platelet activation conditions and effects of altered redox balance on platelet function. The main platelet sources of reactive oxygen species are isoforms of NADPH oxidases, cyclooxygenase, xanthine oxidase, and mitochondrial electron transport chain. Reactive oxygen species produced during platelet activation by agonists act as secondary messengers and can interfere with signaling pathways that enhance agonist-induced platelet activation. The signaling pathway mediated by glycoprotein VI, the main platelet receptor for collagen, leading mainly to the generation of intracellular reactive oxygen species, as well as the signaling pathway activated by thrombin, leading to the production of extracellular reactive oxygen species are considered. Extracellular reactive oxygen species enhance initial signaling and support platelet recruitment and activation. Activated platelets are involved in the coupling of thrombosis, inflammation, and innate immune responses. The platelet antioxidant systems play an important role in preventing the cytotoxic effects of reactive oxygen species, as well as in the regulation of platelet signaling pathways. The authors of the review and other researchers have shown that the redox status of platelets can serve as a biomarker in the studies on prevention and treatment of diseases involving oxidative stress and can be used for objective assessments of the patients' condition severity (including depression and schizophrenia, in which the authors found a decrease in the activity of platelet glutathione -dependent antioxidant enzymes).
LIPID METABOLISM STATE IN MEN UNDER 60 YEARS OLD WITH METABOLIC SYNDROME DURING MYOCARDIAL INFARCTION
Authors: V.A. Reiza , A.V. Golikov , A.V. Gordienko , B.A. Chumak , G.D. Trukhin
Published: April 2022

Abstract: Relevance. The lipid metabolism changes during myocardial infarction (MI) in men with metabolic syndrome (MS) may be important for the MI complications development.
Aim. To evaluate the lipid metabolism changes in acute and subacute MI periods and their role in the MI complications development in men under 60 years old with MS to improve prevention and outcomes.
Material and methods. The study included men aged 19-60 years old with MI and MS. The patients were divided into two age-comparable groups: I - study group, with MS - 95 patients; II - control, without it - 571 patients. A comparative analysis of the lipid metabolism parameters and their dynamics in acute and subacute MI periods in selected groups, analysis of their influence on the risk of MI complications were performed.
Results. It was found that in the first hours of MI in the study group, higher levels of triglycerides (3.19 ± 2.34 mmol/l) were noted compared to the control group (2.44 ± 1.75 mmol/l; p=0.02). The dynamics of lipid metabolism at the end of the third week of MI, significant multidirectional changes in all parameters with more pronounced atherogenic changes in the study group were revealed. The risk of MI complications was associated with levels of triglycerides (TG) ˂5.2 (p=0.02), high density (HDL) ≥0.9 (p=0.04) and very low-density lipoproteins (VLDL) ˂0.9 (p=0.04) (mmol/l) of the first hours of MI.
Conclusions. The presence of MS impairs lipid metabolism in both acute and the subacute MI periods. In the study group, there is an increase in the levels of atherogenic lipids and their indices during the observation period. MI complications are associated with levels TG ˂5.2; HDL ≥0.9 and VLDL ˂0.9 (mmol/l) during the first hours of MI. It is expedient to use them in predictive modeling.
STRUCTURAL-FUNCTIONAL AND MOLECULAR DIAGNOSTIC PARALLELS IN ARTERIAL HYPERTENSION IN ELDERLY PATIENTS
Authors: E.A. Kartashova , E.I. Zheleznyak , Kh.M. Bataev
Published: April 2022

Abstract: Relevance. Among cardiovascular diseases arterial hypertension (AH) in elderly people over 60 years old is the main risk factor for stroke, heart failure, terminal renal failure and lethal outcome. Today hypertension is defined as accelerated aging of the arterial component of the cardiovascular system with developing of remodeling processes due to age. Studies of a molecular phenotype of hypertension in elderly patients with obtaining molecular profiles of biological samples determining the clinical course of hypertension and its classification characteristics are topical nowadays. The aim of the study is to search correlations between structural, functional and molecular diagnostic parameters in patients with AH of Grade 2 of a moderate and high risk. Methods and materials: The study involved patients over 60 years old with a diagnosis of Grade 2, moderate and high risk hypertension (Group 2, n=200), taking into consideration the criteria of inclusion and non-inclusion into the study. The control group (KG, Group 1) included 30 elderly people with no hypertension. Central blood pressure (BP) in the aorta and pressure on the brachial artery were measured, indicators of daily blood pressure monitoring, structural and functional parameters of the heart were evaluated on the basis of echocardiography. There was fulfilled a qualitative proteomic analysis of blood plasma based on time–of–flight mass spectrometry with a laser desorption and ionization and quantitative assessment of the level of proteins in the blood with the help of enzyme immunoassay. Results: There was revealed an increase of the blood concentration of MPO, apoD, HIF1α, TGFβ1, hyaluronidase 1, kininogen 1, fibulin 5 and their significant correlations with LVMM and ACC. Conclusions: There was determined diagnostic molecular profile of blood of elderly patients with AH of Grade 2 and confirmed the involvement of proteins in myocardial and vascular remodeling in elderly patients with AH.
DEVELOPMENT OF COMPOSITION AND ANALYSIS OF DENTAL GEL BASED ON PERILLA FRUTESCENS. L. LIQUID EXTRACT
Authors: T.Yu. Mandzhigoladze , N.V. Nikitina , L.N. Dukkardt
Published: April 2022

Abstract: The aim of the study was to develop and substantiate the optimal composition, as well as methods for analyzing dental gel based on perilla grass of shrub extract of liquid. Based on the results of the studies, optimal adjuvants and compositions of dental gels on composite ointment bases were determined. Process parameters of gels, organoleptic properties, pH index, homogeneity, rheological characteristics, biopharmaceutical and microbiological indices, authenticity and quantitative content of active substances were studied. According to all indicators, the developed dental gels meet the requirements of GF XIV. However, the best structural and mechanical properties and high release kinetics (87%) have composition No.1, which includes PEO 400, PEO 4000, tween-80 and perillas shrub extract liquid, which allowed for subsequent studies with this gel. By TLC, rosemary and coffee acids, as well as tannins, flavonoids, saponins and chlorophyll were identified. The presence of shrub extract with liquid flavonoids in a perilla grass-based gel was confirmed by a cyanidine sample (red staining) and chalkone formation (yellow-orange staining appeared in the presence of alkali when heated). In addition, qualitative reactions were carried out, as a result of which tannins, saponins and chlorophyll were identified. A method of quantifying the sum of flavonoids using differential spectrophotometry in terms of rutin has been developed. As analytical wavelength it is chosen λmax = 395nm. It was found that the content of flavonoids in the gel in terms of rutin is 0,0123 ± 0,0002%. The relative error of the technique does not exceed ± 2,24%.
FEATURES OF THE ORGANOMINERAL COMPOSITION OF THE CENOPOPULATIONS OF MEDICINAL PLANTS OF THE CASPIAN LOWLAND
Authors: L.Ch. Sangadzhieva , E.N. Bambaeva , O.S. Sangadzhieva , Tz.D. Davaeva , Z.V. Sokhorova , A.V. Manzhikova
Published: April 2022

Abstract: The plants growing on the Caspian lowland contain all groups of the studied substances: sugars, tannins and extractives, vitamin C. The conducted studies indicate the prospects of using the studied species as medicinal plant raw materials. It was found that the largest number of low molecular weight BAS contain representatives of the sem. Asteraceae, Brassicaceae, Fabaceae, etc. The features of the accumulation of macronutrients in medicinal plants have been established. The study showed that the mass concentrations of chemical compounds have a strong variation in indicators and depend on the type of selected plants and the properties of the functional zone of growth. According to the absolute content of reducing sugars, cumin, thyme, tansy and chamomile were in the first place: 2.09, 1.98 and 1.95%, although the relative amount of reducing sugars in these species is not very large: 24.4, 30.7 and 33.9%, respectively, of the total amount of sugars. Thus, we can note a general trend for the medicinal plants studied by us: an increase in the proportion of reducing sugars relative to the total amount of sugars with a decrease in the absolute content of the sum of sugars in plants. The following plant species turned out to be the richest in ascorbic acid: sandy cumin, esparcet astragalus, camel thorn, naked licorice and Marshall's thyme (19.80 mg%), pharmacy chamomile, cardaria krupkovidnaya, chicory, yarrow (18.20) and sandy immortelle (17.00). It should be noted that this. Aster contains two species rich in tannins: common tansy and sandy immortelle (3.60 and 5.40%), the remaining species have an average content of 1.80%. Based on the data obtained, it can be concluded that the accumulation of mineral components in the studied medicinal plants is distributed as follows: N(NO3)>K2O>P2O5 and have high levels of variation, this may depend on the species specificity of plants.
DEVELOPMENT OF THE TECHNOLOGY OF GRANULES WITH THE POLYFRACTION EXTRACT ALFREDIA DROOPING (ALFREDIA CERNUA L.)
Authors: N.N. Semenova , D.V. Kompantsev , T.A. Shatalova , L.A. Michnik , Z.D. Hadzhieva
Published: April 2022

Abstract: Alfredia drooping is a source of vegetable raw materials with cerebroprotective, antioxidant and antiradical effects. We obtained a dry polyfraction extract from the lower, petiolate leaves of Alfredia. The purpose of the research is to develop a technology of water-soluble granules based on a polyfraction extract of Alfredia drooping dry for the preparation of a drink. We used polyextract from the leaves of alfredia drooping and water-soluble excipients: maltodextrin DE 12-19, starch sodium glycolate, sodium chloride and sucrose, ethyl alcohol 95% as objects of research. The wet granulation method was used to produce pellets. The technology of the granules consisted in the fact that all the components of the granules (humidity no more than 2%) were mixed, moistened with 95% ethyl alcohol and granulated by pressing through the mesh (holes 2 mm). The granules was dried at a temperature no higher than 30°C to a residual humidity of no more than 2%. The granules were then re-granulated and sieved through a sieve (2 mm holes).In the course of research, the product was evaluated according to the indicators "granulation ability", "disintegration", "uniformity of dosing", "dissolution", "taste". The composition of granules with alfredia polyextract was determined as a result of experiments: polyextract: maltodextrin: sugar: calcium glycerophosphate: starch sodium glycolate: sodium chloride in the ratio 1,41:0,8:1,2:0,16:0,16:0,13 g, respectively. The obtained granules have withstood all tests according to the indicators provided for by GF 14 of the edition: "description", "size of granules", "loss in mass during drying", "disintegration", "uniformity of mass", "microbiological purity". The shelf life for granules with Alfredia extract can be set for a duration of 18 months.