bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Different Salinity Stress on the Transcriptomic Responses of Freshwater Crayfish (Procambarus clarkii, Girard, 1852)
Authors: Luo Lei , Yang Li-Shi , Huang Jian-Hua , Jiang Shi-Gui , Zhou Fa-Lin , Li Yun-Dong , Jiang Song , Yang Qi-Bin
Published: July 2024

Salinization of freshwater ecosystems is a pressing global issue. Changes in salinity can exert severe pressure on aquatic animals and jeopardize their survival. Procambarus clarkii is a valuable freshwater aquaculture species that exhibits some degree of salinity tolerance, making it an excellent research model for freshwater aquaculture species facing salinity stress. In the present study, crayfish were exposed to acute low salt (6 ppt) and high salt (18 ppt) conditions. The organisms were continuously monitored at 6, 24, and 72 h using RNA-Seq to investigate the mechanisms of salt stress resistance. Transcriptome analysis revealed that the crayfish responded to salinity stress with numerous differentially expressed genes, and most of different expression genes was observed in high salinity group for 24h. GO and KEGG enrichment analyses indicated that metabolic pathways were the primary response pathways in crayfish under salinity stress. This suggests that crayfish may use metabolic pathways to compensate for energy loss caused by osmotic stress. Furthermore, gene expression analysis revealed the differential expression of immune and antioxidant-related pathway genes under salinity stress, implying that salinity stress induces immune disorders in crayfish. More genes related to cell proliferation, differentiation, and apoptosis, such as the Foxo, Wnt, Hippo, and Notch signaling pathways, responded to high-salinity stress. This suggests that regulating the cellular replication cycle and accelerating apoptosis may be necessary for crayfish to cope with high-salinity stress. Additionally, we identified 36 solute carrier family (SLC) genes related to ion transport, depicting possible ion exchange mechanisms in crayfish under salinity stress. These findings aimed to establish a foundation for understanding crustacean responses to salinity stress and their osmoregulatory mechanisms.
Bio-Inspired Optimization Algorithm Associated with Reinforcement Learning for Multi-Objective Operating Planning in Radioactive Environment
Authors: Kong Shihan , Wu Fang , Liu Hao , Zhang Wei , Sun Jinan , Wang Jian , Yu Junzhi
Published: July 2024

This paper aims to solve the multi-objective operating planning problem in the radioactive environment. First, a more complicated radiation dose model is constructed, considering difficulty levels at each operating point. Based on this model, the multi-objective operating planning problem is converted to a variant traveling salesman problem (VTSP). Second, with respect to this issue, a novel combinatorial algorithm framework, namely hyper-parameter adaptive genetic algorithm (HPAGA), integrating bio-inspired optimization with reinforcement learning, is proposed, which allows for adaptive adjustment of the hyperparameters of GA so as to obtain optimal solutions efficiently. Third, comparative studies demonstrate the superior performance of the proposed HPAGA against classical evolutionary algorithms for various TSP instances. Additionally, a case study in the simulated radioactive environment implies the potential application of HPAGA in the future.
Experiences of Domestic Violence in Adult Patients with Brain Injury: A Select Overview of Screening, Reporting, and Next Steps
Authors: Chan Jessie P. , Harris Kristen A. , Berkowitz Arielle , Ferber Ally , Greenwald Brian D. , Valera Eve M.
Published: July 2024

This select overview examines the important intersection of adult domestic violence, including intimate partner violence and elder abuse, with brain injury. Despite the high prevalence of domestic violence amongst brain injury patients, there is a notable gap in screening and management training for providers. To provide optimal patient care, brain injury medicine clinicians must screen, recognize, and treat patients who have experienced domestic violence. This select overview highlights barriers to screening, validated screening tools from other medical disciplines, and management considerations for the brain injury clinician. A suggested protocol for domestic violence screening and management, as well as recommended resources for providers and patients, is summarized.
Hyperactivity in ADHD: Friend or Foe?
Authors: Hoy Beverly-Ann , Bi Michelle , Lam Matthew , Krishnasamy Gayuni , Abdalmalak Androu , Fenesi Barbara
Published: July 2024

Background: Hyperactivity may play a functional role in upregulating prefrontal cortical hypoarousal and executive functioning in ADHD. This study investigated the neurocognitive impact of movement during executive functioning on children with ADHD. Methods: Twenty-four children with and without ADHD completed a Stroop task and self-efficacy ratings while remaining stationary (Stationary condition) and while desk cycling (Movement condition). Simultaneous functional near-infrared spectroscopy (fNIRS) recorded oxygenated and deoxygenated changes in hemoglobin within the left dorsolateral prefrontal cortex (DLPFC). Results: Among children with ADHD, the Movement condition produced superior Stroop reaction time compared to the Stationary condition (p = 0.046, d = 1.00). Self-efficacy improved in the Movement condition (p = 0.033, d = 0.41), whereas it did not in the Stationary condition (p = 0.323). Seventy-eight percent of participants showed greater oxygenation in the left DLPFC during the Movement condition vs. the Stationary condition. Among children without ADHD, there were no differences in Stroop or self-efficacy outcomes between Stationary and Movement conditions (ps > 0.085, ts < 1.45); 60% of participants showed greater oxygenation in the left DLPFC during the Movement vs. the Stationary condition. Conclusions: This work provides supportive evidence that hyperactivity in ADHD may be a compensatory mechanism to upregulate PFC hypoarousal to support executive functioning and self-efficacy.
Modeling and Assessment of Temperature and Thermal Stress Field of Asphalt Pavement on the Tibetan Plateau
Authors: Li Bin , Xie Yadong , Bi Yanqiu , Zou Xiaoling , Tian Fafu , Cong Zhimin
Published: July 2024

The Qinghai–Tibet Plateau (QTP) is the highest altitude plateau in the world, characterized by strong solar radiation and large diurnal temperature differences and so on, which brings a great negative impact on the temperature and thermal stress field of asphalt pavement. The purpose of this study is to analyze the temperature field and thermal stress status of asphalt pavement in the QTP to provide a reference for pavement design and maintenance in high-altitude areas. The finite element method was applied to establish the temperature field model to study the distribution and variation of pavement temperature. On this basis, the influence of cooling amplitude on pavement thermal stress was studied during cold waves. In addition to this, the key internal factors affecting the thermal stress of pavement, such as surface thickness, surface temperature shrinkage coefficient, surface modulus, and base modulus, were analyzed by an orthogonal test. It was found that temperature and solar radiation have a significant effect on the pavement temperature field. When the cold wave came, the cooling rate had a considerable impact on the thermal stress of the pavement, that is, every 5 °C increase in cooling rate would increase the thermal stress by more than 50%. The temperature shrinkage coefficient and surface modulus of the surface layer material had the greatest influence on the pavement thermal stress. The thermal stress could be reduced by more than 0.4 Mpa for every 5 × 10−6/°C reduction in the surface temperature shrinkage coefficient or every 1000 Mpa reduction in the surface modulus. This study can provide a reference for improving the temperature field and thermal stress field of asphalt pavement in the plateau area.
Selection of 110 kV Prefabricated Steel Substations Considering Seismic Vulnerability in China
Authors: Che Weixian , Liang Junbo , Deng Jun , Yi Jiang
Published: July 2024

Prefabricated modular substations are expected to become the mainstream construction type for substations in China. However, there is a lack of scientific basis for structural selection and seismic performance evaluation. Taking a 110 kV substation as an example, this study compares the construction cost of cast-in situ reinforced concrete (RC) substations and prefabricated steel (PS) ones. Two types of PS structures are considered: one with H-section steel columns and the other with box-section steel columns. A seismic vulnerability analysis is performed to compare the probability distribution of various damage states of substation building structures under different seismic damage levels. Results indicate that the construction cost of PS structures is approximately 27.9% higher than that of cast-in situ concrete. When using H-section steel columns, there is a significant difference in the flexural stiffness in two horizontal directions, resulting in reduced seismic performance in the weak-axis direction. The construction cost of using box-section steel columns is slightly higher than that of the H-section steel case, but its seismic performance is significantly improved. Although the probability of slight and moderate damage states for the box-section steel column scheme is generally higher than that of the cast-in situ RC scheme, the probability of collapse is reduced. Thus, box-section steel columns are recommended for prefabricated modular substation building structures.
Study on the Repair Effect of Self-Healing Cementitious Material with Urea-Formaldehyde Resin/Epoxy Resin Microcapsule
Authors: Mao Hanqing , Cao Xuemei , Guo Minru , Jiang Chaozhe , Chen De
Published: July 2024

Recent studies on microencapsulated self-healing cementitious materials have primarily focused on the particle size and preparation methods of the microcapsules. However, there has been limited attention paid to the microscopic aspects, such as the selection of curing agents and the curing duration of these materials. In this study, urea-formaldehyde resin/epoxy resin E-51 microcapsules were synthesized through in situ polymerization. This research investigates the feasibility of self-healing from a molecular mechanism perspective and evaluates the repair performance of microencapsulated self-healing cement mortar with varying microcapsule concentrations, curing agent types, and curing ages. The findings demonstrate that the microcapsule shells bond effectively with the cementitious matrix, with radial distribution function peaks all located within 3.5 Å. The incorporation of microcapsules enhanced the tensile strength of the modified cement mortar by 116.83% and increased the failure strain by 110%, indicating improved adhesion and mechanical properties. The restorative agent released from the microcapsule core provided greater strength after curing compared to the uncured state. Although the overall strength of the microencapsulated self-healing cement mortar decreased with higher microcapsule concentrations, the repair efficiency improved. The strength recovery rate of 28-day aged modified cement mortar had a significant improvement with the addition of X and Y curing agents, respectively.
Enhancing Post-Mastectomy Care: Telehealth’s Impact on Breast Reconstruction Accessibility for Breast Cancer Patients
Authors: Stearns Stephen A. , Lee Daniela , Bustos Valeria P. , Haddad Anthony , Hassell Natalie , Kim Erin , Foppiani Jose A. , Lee Theodore C. , Lin Samuel J. , Lee Bernard T.
Published: July 2024

Objective: To examine how the recent sharp rise in telemedicine has impacted trends in accessibility of breast reconstruction (BR). Patients and Methods: A retrospective study reviewed patients who underwent a total mastectomy at our institution from 1 August 2016 to 31 January 2022. By comparing cohorts before and during the widespread implementation of telemedicine, we assessed telehealth’s impact on healthcare accessibility, measured by distance from patients’ residences to our institution. Results: A total of 359 patients were included in this study. Of those, 176 received total mastectomy prior to the availability of telemedicine, and 183 in the subsequent period. There were similar baseline characteristics among patients undergoing mastectomy, including distance from place of residence to hospital (p = 0.67). The same proportion elected to receive BR between groups (p = 0.22). Those declining BR traveled similar distances as those electing the procedure, both before the era of widespread telemedicine adoption (40.3 and 35.6 miles, p = 0.56) and during the height of telemedicine use (22.3 and 61.3 miles, p = 0.26). When tracking follow-up care, significantly more patients during the pandemic pursued at least one follow-up visit with their original surgical team, indicative of the increased utilization of telehealth services. Conclusions: While the rate of BR remained unchanged during the pandemic, our findings reveal significant shifts in healthcare utilization, highly attributed to the surge in telehealth adoption. This suggests a transformative impact on breast cancer care, emphasizing the need for continued exploration of telemedicine’s role in enhancing accessibility and patient follow-up in the post-pandemic era.
Epithelioid Hemangioma of the Spine: A Case Series and Treatment Flow Chart—Experience from a Single Centre
Authors: Asunis Emanuela , Cini Chiara , De Robertis Mario , Griffoni Cristiana , Bandiera Stefano , Righi Alberto , Ghermandi Riccardo , Pipola Valerio , Girolami Marco , Tedesco Giuseppe , Gambarotti Marco , Gasbarrini Alessandro
Published: July 2024

Epithelioid hemangioma is recognized by the World Health Organization as a distinct benign neoplasm; however, it is characterized by locally aggressive and rarely metastasizing behavior. Epithelioid vascular tumors are rare bony vascular lesions with varying degrees of malignant potential that remain controversial because of their rarity, unusual morphological features, and unpredictable biological behavior. The application of new molecular tools, such as massive parallel sequencing technologies, have provided new diagnostic markers and an opportunity to further refine the classification of bone vascular neoplasms. Very few cases of EH of the spine have been reported in the literature; therefore, it is difficult to make evidence-based therapeutic decisions for these patients. We report herein our experience with eleven patients suffering from EH of the spine. The study population included three males and eight females treated in our center from 2016 to the present; the average age was 44.8 years (range 14–75 years). The surgical, clinical, and radiographic data were retrospectively analyzed. The mean follow-up was 34.8 months. All patients presented lytic vertebral body lesions, six of them with pathological fracture. The majority of patients (80%) presented myelo-radicular compression. All patients were surgically treated, and preoperative embolization was performed in all cases. In light of the literature review and the clinical experience of our center, we can consider EH a locally aggressive tumor that requires surgical treatment in case of symptoms. Here, we propose a treatment algorithm that could be useful in the management of patients with this rare disease.
Efficacy of Ipilimumab and Nivolumab in Patients with Melanoma and Brain Metastases—A Danish Real-World Cohort
Authors: Kattenhøj Karoline Dreyer , Møberg Christine Louise , Guldbrandt Louise Mahncke , Friis Rasmus Blechingberg , Mapendano Christophe Kamungu , Petersen Søren Kjær , Ruhlmann Christina Halgaard Bruvik , Svane Inge Marie , Donia Marco , Ellebaek Eva , Schmidt Henrik
Published: July 2024

Combination immunotherapy using ipilimumab/nivolumab is the golden standard treatment for patients with melanoma and asymptomatic brain metastases (MBM). However, it remains uncertain if real-world patients have the same treatment effects compared to patients enrolled in clinical trials. The aim of this study was to compare clinical benefits between real-world patients and patients enrolled in clinical trials when administering ipilimumab/nivolumab in treatment-naive patients with asymptomatic MBM. Using data from the Danish Metastatic Melanoma Database (DAMMED), 79 patients with clinical parameters similar to the inclusion criteria from two phase II trials, the ABC and the CheckMate-204 trials, were included in the analyses. Thirteen patients (16.5%) achieved complete response (CR) and an overall response rate (ORR) of 46.9%. We found an overall 6-month Progression-Free Survival (PFS) rate of 53.5% and a median PFS of 6.5 months. Median overall survival (mOS) was not reached during the 5-year follow-up. These results were comparable to the phase II trials. In conclusion, clinical benefits from phase II studies were comparable to Danish real-world data regarding OS, PFS, and CR. Confirming that combination immunotherapy can be recommended as first-line treatment for patients with asymptomatic, treatment-naive melanoma brain metastases.
Genetic Testing Uptake among Ovarian Cancer Survivors in the Genetic Risk Analysis in Ovarian Cancer (GRACE) Study
Authors: White Larissa , Sawyer Jennifer , Zepp Jamilyn , Prado Yolanda , Reyes Ana , Maiyani Mahesh , Shuster Elizabeth , Zucker Rachel , Henrikson Nora , Rope Alan , Weinmann Sheila , Feigelson Heather , Ezzell Hunter Jessica
Published: July 2024

Background: Recommendations state all people with ovarian cancers (OCs) receive genetic counseling, but testing uptake is only between 15 and 31%. Those with a prior diagnosis of OC who have not received genetic testing represent a missed opportunity for life-saving genetic risk information. The Genetic Risk Analysis in ovarian CancEr (GRACE) study aimed to evaluate the feasibility of the retrospective identification (“Traceback”) of individuals diagnosed with OC. Methods: This nonrandomized intervention study within two integrated health care systems identified participants with a history of OC between 1998 and 2020 who did not have genetic testing or testing limited to BRCA1/2. Participants received clinical genomic sequencing via a custom 60 gene panel. This study measured the feasibility of the Traceback methodology in OC survivors. Results: The initial cohort included 929 individuals, of which 57% had no prior genetic testing. Of the 302 eligible for recruitment, 88 consented to participate. We were able to outreach 97% of the eligible population using contact information from medical records. The stage at diagnosis was the only factor associated with consent. Of the 78 who returned their saliva sample, 21% had pathogenic/likely pathogenic variants, and 79% had negative results. Conclusion: The GRACE study resulted in a 29% uptake of genetic testing in OC survivors. The time since diagnosis did not have an impact on consent or ability to contact. GRACE can inform the implementation of future Traceback programs, providing guidance on how to prevent and mitigate the burden of OC and other hereditary cancers.
Non-Invasive 3D Breast Tumor Localization: A Viable Alternative to Invasive Tumor Marking
Authors: Bjelica Dragana , Colakovic Natasa , Opric Svetlana , Zdravkovic Darko , Loboda Barbara , Petricevic Simona , Gojgic Milan , Zecic Ognjen , Skuric Zlatko , Zecic Katarina , Ivanovic Nebojsa
Published: July 2024

Background: We present a detailed description and the preliminary results of our original technique for non-invasive three-dimensional tumor localization in the breast, which was created as an alternative to standard invasive tumor marking before neoadjuvant systemic therapy (NAST), aiming to enable adequate surgery after complete tumor regression. Methods: A detailed description of the technique is provided in the main text. The technique’s feasibility and precision were assessed in a single-arm, prospective study based on the histological parameters of the adequacy and rationality of the excision of completely regressed tumor beds. Results: Out of 94 recruited patients, 15 (16%) were deemed unsuitable, mainly due to the tumors’ inadequate ultrasound visibility. Among the 79 processed patients, 31 (39%) had complete clinical regression after NAST and were operated on using our technique. The histological parameters of surgical precision (signs of tumor regression: 24/31; microscopic cancer residues: 7/31) were verified in all excised specimens (100% precision). There were no positive margins in seven cases with microscopic residues, indicating our technique’s capacity to enable oncologically safe post-NAST surgery. Conclusions: The proposed technique is feasible and satisfactorily accurate in determining the location of regressed tumors, thus representing an alternative to invasive tumor marking, especially in surgical centers lacking trained staff and equipment for invasive marking. The technique’s limitations are mainly related to the inadequate ultrasound visibility of the tumor.
Reduced Dose of Post-Transplant Cyclophosphamide with Tacrolimus for the Prevention of Graft-versus-Host Disease in HLA-Matched Donor Peripheral Blood Stem Cell Transplants: A Prospective Pilot Study
Authors: Juárez Alex , Salas María Queralt , Pedraza Alexandra , Suárez-Lledó María , Rodríguez-Lobato Luís Gerardo , Solano María Teresa , Serrahima Anna , Nomdedeu Meritxell , Cid Joan , Lozano Miquel , Charry Paola , Arcarons Jordi , Llobet Noemí , Rosiñol Laura , Fernández-Avilés Francesc , Rovira Montserrat , Martínez Carmen
Published: July 2024

PTCY 50 mg/kg/day on days +3/+4 is an excellent strategy to prevent GVHD. However, its use is associated with adverse outcomes such as delayed engraftment, increased risk of infection, and cardiac complications. This pilot study evaluates the efficacy and toxicity of a reduced dose of PTCY (40 mg/kg/day) combined with tacrolimus in 22 peripheral blood HLA-matched alloHSCT patients. At day +100, the cumulative incidences of grade II–IV and III–IV acute GVHD were 18.2% and 4.5%, respectively. No grade IV acute GVHD or steroid-refractory disease was observed. The cumulative incidences of all-grade and moderate-severe chronic GVHD at 1-year were 11.4% and 6.4%, respectively. No patient died from transplant-related complications. Two-year OS and RFS were 77.1% and 58.3%, respectively. All patients engrafted, with neutrophil and platelet recovery occurring at a median of 15 (IQR 14–16) and 16 days (IQR 12–23), respectively. The cumulative incidences of bloodstream bacterial infections, polyomavirus BK hemorrhagic cystitis, HHV6 reactivation, CMV reactivation, and fungal infections were 13.6%, 9.1%, 9.1%, 4.6%, and 6%, respectively. Only one early cardiac event was observed. These results suggest that PTCY 40 mg/kg/day on a +3/+4 schedule provides adequate immunosuppression to allow for engraftment and prevent clinically significant GVHD with a low toxicity profile.
Impact of Genomic Mutation on Melanoma Immune Microenvironment and IFN-1 Pathway-Driven Therapeutic Responses
Authors: Mentucci Fátima María , Romero Nuñez Elisa Ayelén , Ercole Agustina , Silvetti Valentina , Dal Col Jessica , Lamberti María Julia
Published: July 2024

The BRAFV600E mutation, found in approximately 50% of melanoma cases, plays a crucial role in the activation of the MAPK/ERK signaling pathway, which promotes tumor cell proliferation. This study aimed to evaluate its impact on the melanoma immune microenvironment and therapeutic responses, particularly focusing on immunogenic cell death (ICD), a pivotal cytotoxic process triggering anti-tumor immune responses. Through comprehensive in silico analysis of the Cancer Genome Atlas data, we explored the association between the BRAFV600E mutation, immune subtype dynamics, and tumor mutation burden (TMB). Our findings revealed that the mutation correlated with a lower TMB, indicating a reduced generation of immunogenic neoantigens. Investigation into immune subtypes reveals an exacerbation of immunosuppression mechanisms in BRAFV600E-mutated tumors. To assess the response to ICD inducers, including doxorubicin and Me-ALA-based photodynamic therapy (PDT), compared to the non-ICD inducer cisplatin, we used distinct melanoma cell lines with wild-type BRAF (SK-MEL-2) and BRAFV600E mutation (SK-MEL-28, A375). We demonstrated a differential response to PDT between the WT and BRAFV600E cell lines. Further transcriptomic analysis revealed upregulation of IFNAR1, IFNAR2, and CXCL10 genes associated with the BRAFV600E mutation, suggesting their involvement in ICD. Using a gene reporter assay, we showed that PDT robustly activated the IFN-1 pathway through cGAS-STING signaling. Collectively, our results underscore the complex interplay between the BRAFV600E mutation and immune responses, suggesting a putative correlation between tumors carrying the mutation and their responsiveness to therapies inducing the IFN-1 pathway, such as the ICD inducer PDT, possibly mediated by the elevated expression of IFNAR1/2 receptors
HSV-1 and Cellular miRNAs in CSF-Derived Exosomes as Diagnostically Relevant Biomarkers for Neuroinflammation
Authors: Scheiber Christian , Klein Hans C. , Schneider Julian M. , Schulz Tanja , Bechter Karl , Tumani Hayrettin , Kapapa Thomas , Flinkman Dani , Coffey Eleanor , Ross Duncan , Čistjakovs Maksims , Nora-Krūkle Zaiga , Bortolotti Daria , Rizzo Roberta , Murovska Modra , Schneider E. Marion
Published: July 2024

Virus-associated chronic inflammation may contribute to autoimmunity in a number of diseases. In the brain, autoimmune encephalitis appears related to fluctuating reactivation states of neurotropic viruses. In addition, viral miRNAs and proteins can be transmitted via exosomes, which constitute novel but highly relevant mediators of cellular communication. The current study questioned the role of HSV-1-encoded and host-derived miRNAs in cerebrospinal fluid (CSF)-derived exosomes, enriched from stress-induced neuroinflammatory diseases, mainly subarachnoid hemorrhage (SAH), psychiatric disorders (AF and SZ), and various other neuroinflammatory diseases. The results were compared with CSF exosomes from control donors devoid of any neuroinflammatory pathology. Serology proved positive, but variable immunity against herpesviruses in the majority of patients, except controls. Selective ultrastructural examinations identified distinct, herpesvirus-like particles in CSF-derived lymphocytes and monocytes. The likely release of extracellular vesicles and exosomes was most frequently observed from CSF monocytes. The exosomes released were structurally similar to highly purified stem-cell-derived exosomes. Exosomal RNA was quantified for HSV-1-derived miR-H2-3p, miR-H3-3p, miR-H4-3p, miR-H4-5p, miR-H6-3p, miR-H27 and host-derived miR-21-5p, miR-146a-5p, miR-155-5p, and miR-138-5p and correlated with the oxidative stress chemokine IL-8 and the axonal damage marker neurofilament light chain (NfL). Replication-associated miR-H27 correlated with neuronal damage marker NfL, and cell-derived miR-155-5p correlated with oxidative stress marker IL-8. Elevated miR-138-5p targeting HSV-1 latency-associated ICP0 inversely correlated with lower HSV-1 antibodies in CSF. In summary, miR-H27 and miR-155-5p may constitute neuroinflammatory markers for delineating frequent and fluctuating HSV-1 replication and NfL-related axonal damage in addition to the oxidative stress cytokine IL-8 in the brain. Tentatively, HSV-1 remains a relevant pathogen conditioning autoimmune processes and a psychiatric clinical phenotype.
The Nature of Pointer States and Their Role in Macroscopic Quantum Coherence
Authors: Turner Philip , Nottale Laurent
Published: July 2024

This article begins with an interdisciplinary review of a hydrodynamic approach to understanding the origins and nature of macroscopic quantum phenomena in high-temperature superconductivity, superfluidity, turbulence and biological systems. Building on this review, we consider new theoretical insights into the origin and nature of pointer states and their role in the emergence of quantum systems. The approach includes a theory of quantum coherence underpinned by turbulence, generated by a field of pointer states, which take the form of recirculating, spin-1/2 vortices (toroids), interconnected via a cascade of spin-1 vortices. Decoherence occurs when the bosonic network connecting pointer states is disrupted, leading to their localisation. Building further on this work, we explore how quantum particles (in the form of different vortex structures) could emerge as the product of a causal dynamic process, within a turbulent (fractal) spacetime. The resulting particle structures offer new insights into intrinsic spin, the probabilistic nature of the wave function and how we might consider pointer states within the standard “point source” representation of a quantum particle, which intuitively requires a more complexed description.
Ag-Coated Super Duplex Stainless Steel AISI2507 with or without Crystallization of Secondary Phase as Advanced Li-Ion Battery Case Material
Authors: Jo Hyeongho , Ok Jung-Woo , Lee Yoon-Seok , Je Yonghun , Kim Shinho , Kim Seongjun , Park Jinyong , Lee Jaeyeong , Shin Byung-Hyun , Yoon Jang-Hee , Kim Yangdo
Published: July 2024

Li-ion batteries used in portable electronic devices and electric vehicles require high safety standards, necessitating the use of high-performance structural materials for battery casings. Super duplex stainless steel (SDSS) is a structural material suitable for portable electronic products owing to its excellent strength and corrosion resistance. SDSS AISI2507 was used to construct a Li-ion battery casing, a Ag coating was applied via physical vapor deposition (PVD) after the heat treatment of AISI2507 with or without a secondary phase, and the coating thickness was controlled by varying the PVD time. The thickness of the Ag coating layer increased proportionally with time, thereby enhancing the electrical conductivity. The structure and coating behavior were confirmed using FE-SEM, XRD, and GDS. The secondary phase was crystallized by the segregation of the alloy and formed a BCC structure. The FCC lattice structure exhibited excellent coating behavior on the austenite (FCC structure) of AISI2507. Conversely, the secondary phase exhibited low adhesion owing to differences in composition and crystal structure. However, the Ag coating layer on AISI2507 exhibited excellent electrical conductivity, outperforming conventional Ni-plated Li-ion battery casings comprising AISI304. However, the precipitation of the secondary phase must be controlled, as the formation of the secondary phase acts as a factor that decreases electrical conductivity from 58.8 to 53.6 (ICAS) %. The excellent performance of Ag-coated AISI2507 makes it suitable for the fabrication of enhanced Li-ion battery casings.
Exploring Reduced Graphene Oxide Sheets Stabilized by Cu(II) and Cu(I) Cations in Ethanol
Authors: Jezzini Aya , Davidson Anne , Hamieh Tayssir , Toufaily Joumana
Published: July 2024

In this study, ultrasound treatment was used to exfoliate commercially available graphite flakes into reduced graphene oxide (rGO) dispersed in ethanol. After centrifugation, solid copper chloride trihydrate was added, resulting in a green liquor containing Cu(II), Cu(I), and rGO. These liquors exhibited good and rapid photocatalytic activity in the degradation of eosin and bromophenol blue dyes (elimination in a few seconds) under visible-light irradiation. UV–visible spectroscopy confirmed the presence of rGO and Cu species. The size and morphology of the rGO sheets were investigated by several methods (SAXS, wide-angle XRD, SEM, and TEM). Negative UV peaks indicated light emission, which was independently verified by fluorescence. Intense plasmon peaks, with absorbances greater than 10, were observed after adding copper chloride salt. These plasmons were eliminated by a high dilution before the described catalytic tests were performed.
Ternary Copper(II) Coordination Compounds with Nonpolar Amino Acids and 2,2′-Bipyridine: Monomers vs. Polymers
Authors: Vušak Darko , Ležaić Katarina , Judaš Nenad , Prugovečki Biserka
Published: July 2024

Reactions of copper(II) sulfate with 2,2′-bipyridine (bipy) and amino acids with nonpolar side chains (l-alanine (HAla), l-valine (HVal), or l-phenylalanine (HPhe)) were investigated under different solution-based and mechanochemical methods. Five new ternary coordination compounds were obtained by a solution-based synthesis and three of them additionally by the liquid-assisted mechanochemical method: {[Cu(μ-l-Ala)(H2O)(bipy)]2SO4·2H2O}n (1a·2H2O), {[Cu(μ-l-Ala)(H2O)(bipy)][Cu(l-Ala)(H2O)(bipy)]SO4·2.5H2O}n (1b·2.5H2O), {[Cu(μ-l-Val)(H2O)(bipy)][Cu(l-Val)(H2O)(bipy)]3(SO4)2·4H2O}n (2·4H2O), [Cu(l-Phe)(H2O)(bipy)][Cu(l-Phe)(SO4)(bipy)]∙8H2O (3·8H2O), and [Cu(l-Phe)(H2O)(bipy)][Cu(l-Phe)(SO4)(bipy)]∙9H2O (3·9H2O). The compounds were characterized by single-crystal and powder X-ray diffraction, infrared spectroscopy, and a thermal analysis. Structural studies revealed two structural types, monomeric in 3·8H2O and 3·9H2O, polymeric architectures in 1a·2H2O, and mixed structures (monomeric and polymeric) in 1b·2.5H2O and 2·4H2O. The copper(II) ion is either pentacoordinated or hexacoordinated, with an observed Jahn–Teller effect. The crystal structures are based on an intensive network of hydrogen bonds and π interactions. 1a·2H2O and 2·4H2O showed substantial in vitro antiproliferative activity toward human hepatocellular carcinoma (HepG2) and moderate activity toward human acute monocytic leukemia cell lines (THP-1).
Habitat Suitability Analysis and Future Distribution Prediction of Giant Panda (Ailuropoda melanoleuca) in the Qinling Mountains, China
Authors: Ma Qi , Zhang Huihui , Liu Jiechao , Guo Yiman , Liu Kang
Published: July 2024

Climate change has triggered a series of global problems, posing a huge threat to the distribution of many plants and animals, especially endangered species such as the giant panda. Therefore, predicting the distribution of habitat quality under climate change conditions is of great significance for protecting these species. In this study, we examined the correlation between suitable habitat index and ecosystem services using 260 occurrence records and 13 environmental factors with giant pandas as the model species. The species distribution models can also be employed to predict and compare the potential geographical distribution of giant pandas at present and in the 2050s and 2090s in the Qinling Mountains of Shaanxi Province. The results show the following: (1) The relationship between suitable habitat index and ecosystem services of giant panda is not uniform. (2) From 2040 to 2100, the existing habitats may decrease by 47.8% to 98.5%. (3) The main direction of change in the center of the distribution of the giant panda’s habitat is to migrate first eastward and then northwestward. Our results regarding the potential distribution pattern of giant pandas in the Qinling Mountains and their response to climate change can provide important references for optimizing the conservation and habitat management of wild giant pandas in the Qinling Mountains.
Using Biosensors to Detect and Map Language Areas in the Brain for Individuals with Traumatic Brain Injury
Authors: Alduais Ahmed , Alarifi Hessah Saad , Alfadda Hind
Published: July 2024

The application of biosensors in neurolinguistics has significantly advanced the detection and mapping of language areas in the brain, particularly for individuals with brain trauma. This study explores the role of biosensors in this domain and proposes a conceptual model to guide their use in research and clinical practice. The researchers explored the integration of biosensors in language and brain function studies, identified trends in research, and developed a conceptual model based on cluster and thematic analyses. Using a mixed-methods approach, we conducted cluster and thematic analyses on data curated from Web of Science, Scopus, and SciSpace, encompassing 392 articles. This dual analysis facilitated the identification of research trends and thematic insights within the field. The cluster analysis highlighted Functional Magnetic Resonance Imaging (fMRI) dominance and the importance of neuroplasticity in language recovery. Biosensors such as the Magnes 2500 watt-hour (WH) neuromagnetometer and microwire-based sensors are reliable for real-time monitoring, despite methodological challenges. The proposed model synthesizes these findings, emphasizing biosensors’ potential in preoperative assessments and therapeutic customization. Biosensors are vital for non-invasive, precise mapping of language areas, with fMRI and repetitive Transcranial Magnetic Stimulation (rTMS) playing pivotal roles. The conceptual model serves as a strategic framework for employing biosensors and improving neurolinguistic interventions. This research may enhance surgical planning, optimize recovery therapies, and encourage technological advancements in biosensor precision and application protocols.
Single-Nucleotide Polymorphisms in WNT Genes in Patients with Non-Syndromic Orofacial Clefts in a Polish Population
Authors: Zawiślak Alicja , Woźniak Krzysztof , Tartaglia Gianluca , Agirre Xabier , Gupta Satish , Kawala Beata , Znamirowska-Bajowska Anna , Grocholewicz Katarzyna , Prosper Felipe , Lubiński Jan , Jakubowska Anna
Published: July 2024

Non-syndromic orofacial cleft (OFC) is the most common facial developmental defect in the global population. The etiology of these birth defects is complex and multifactorial, involving both genetic and environmental factors. This study aimed to determine if SNPs in the WNT gene family (rs1533767, rs708111, rs3809857, rs7207916, rs12452064) are associated with OFCs in a Polish population. The study included 627 individuals: 209 children with OFCs and 418 healthy controls. DNA was extracted from saliva for the study group and from umbilical cord blood for the control group. Polymorphism genotyping was conducted using quantitative PCR. No statistically significant association was found between four variants and clefts, with odds ratios for rs708111 being 1.13 (CC genotype) and 0.99 (CT genotype), for rs3809857 being 1.05 (GT genotype) and 0.95 (TT genotype), for rs7207916 being 0.86 (AA genotype) and 1.29 (AG genotype) and for rs12452064 being 0.97 (AA genotype) and 1.24 (AG genotype). However, the rs1533767 polymorphism in WNT showed a statistically significant increase in OFC risk for the GG genotype (OR = 1.76, p < 0.001). This research shows that the rs1533767 polymorphism in the WNT gene is an important risk marker for OFC in the Polish population.
Community Point of Care Testing in Diagnosing and Managing Chronic Kidney Disease
Authors: Gama Rouvick Mariano , Nebres Danilo , Bramham Kate
Published: July 2024

Chronic kidney disease (CKD) poses a significant global health challenge with increasing prevalence and associated morbidity. Point-of-care testing (POCT) provides an opportunity to improve CKD management and outcomes through early detection and targeted interventions, particularly in underserved communities. This review evaluates the roles of POCT in CKD, focusing on utility (through screening programs, monitoring of kidney function, and assessing participants on renally excreted medications), accuracy, and acceptability. Screening programs employing POCT have demonstrated promising outcomes, with improved rates of CKD diagnosis in groups with disparate health outcomes, offering a vital avenue for early intervention in high-risk populations. These have been conducted in rural and urban community or pharmacy settings, highlighting convenience and accessibility as important facilitators for participants. In addition, POCT holds significant promise in the monitoring of CKD, particularly in groups requiring frequent testing, such as kidney transplant recipients and patients on renin-angiotensin-aldosterone inhibitors. The consideration of the variable analytical performance of different devices remains crucial in assessing the utility of a POCT intervention for CKD. While the convenience and improved accessibility of home self-testing versus healthcare professional management is important, it must be balanced with acceptable levels of accuracy and precision to maintain patient and clinical confidence. Despite challenges including variability in accuracy and the user-friendliness of devices, patient feedback has generally remained positive, with studies reporting increased patient satisfaction and engagement. However, challenges regarding wider uptake are limited by healthcare professional confidence (in test reliability), the potential for increased workload, and early prohibitive costs. In conclusion, POCT represents a growing and valuable tool in enhancing CKD care, particularly in resource-limited settings, but careful consideration of device selection and implementation strategies is essential to achieve desired outcomes.
Thrombotic Long-Term Consequences of SARS-CoV-2 Infection in Patients with Compensated Cirrhosis: A Propensity Score-Matched Analysis of a U.S. Database
Authors: Ayoub Mark , Faris Carol , Juranovic Tajana , Aibani Rafi , Koontz Morgan , Chela Harleen , Anwar Nadeem , Daglilar Ebubekir
Published: July 2024

Background: Cirrhosis causes an imbalance in the coagulation pathway and leads to a tendency for both bleeding and clotting. SARS-CoV-2 has been reported to be associated with a hypercoagulable state. This study examines SARS-CoV-2’s impact on hemostasis in compensated patients with cirrhosis. Methods: We analyzed the US Collaborative Network, which comprises 63 HCOs in the U.S.A. Compensated cirrhosis patients were split into two groups: SARS-CoV-2-positive and -negative. Patients’ baseline characteristics were used in a 1:1 propensity score-matched module to create comparable cohorts. We compared the risk of portal vein thrombosis (PVT), deep venous thrombosis (DVT), and pulmonary embolism (PE) at 6 months, and 1 and 3 years. Results: Of 330,521 patients, 27% tested positive and 73% remained negative. After PSM, both cohorts included 74,738 patients. Patients with SARS-CoV-2 had a higher rate of PVT compared to those without at 6 months (0.63% vs 0.5%, p < 0.05), 1 year (0.8% vs 0.6%, p < 0.05), and 3 years (1% vs. 0.7%, p < 0.05), a higher rate of DVT at 6 months (0.8% vs. 0.4%, p < 0.05), 1 year (1% vs. 0.5%, p < 0.05), and 3 years (1.4% vs. 0.8%, p < 0.05), and a higher rate of PE at 6 months (0.6% vs. 0.3%, p < 0.05), 1 year (0.7% vs. 0.4%, p < 0.05), and 3 years (1% vs. 0.6%, p < 0.05). Conclusions: The presence of SARS-CoV-2 infection in patients with compensated cirrhosis was associated with a higher rate of PVT, DVT, and PE at 6 months, and 1 and 3 years.
Supporting Immersive Video Streaming via V2X Communication
Authors: Huang Chenn-Jung , Hu Kai-Wen , Jian Mei-En , Lien Yi-Hung , Cheng Hao-Wen
Published: July 2024

With the rapid advancement of autonomous driving and network technologies, future vehicles will function as network nodes, facilitating information transmission. Concurrently, in-vehicle entertainment systems will undergo substantial enhancements. Beyond traditional broadcasting and video playback, future systems will integrate immersive applications featuring 360-degree views and six degrees of freedom (6DoF) capabilities. As autonomous driving technology matures, vehicle passengers will be able to engage in a broader range of entertainment activities while on the move. However, this evolution in video applications will significantly increase bandwidth demand for vehicular networks, potentially leading to bandwidth shortages in congested traffic areas. This paper presents a method for bandwidth allocation for vehicle video applications within the landscape of vehicle-to-everything (V2X) networks. By utilizing a millimeter-wave (mmWave), terahertz (THz) frequency band, and cell-free (CF) extremely large-scale multiple-input multiple-output (XL-MIMO) wireless communication technologies, we provide vehicle passengers with the necessary bandwidth resources. Additionally, we address bandwidth contention issues in congested road segments by incorporating communication methods tailored to the characteristics of vehicular environments. By classifying users and adjusting according to the unique requirements of various multimedia applications, we ensure that real-time applications receive adequate bandwidth. Simulation experiments validate the proposed method’s effectiveness in managing bandwidth allocation for in-vehicle video applications within V2X networks. It increases the available bandwidth during peak hours by 32%, demonstrating its ability to reduce network congestion and ensure smooth playback of various video application types.
A MobileFaceNet-Based Face Anti-Spoofing Algorithm for Low-Quality Images
Authors: Xiao Jianyu , Wang Wei , Zhang Lei , Liu Huanhua
Published: July 2024

The Face Anti-Spoofing (FAS) methods plays a very important role in ensuring the security of face recognition systems. The existing FAS methods perform well in short-distance scenarios, e.g., phone unlocking, face payment, etc. However, it is still challenging to improve the generalization of FAS in long-distance scenarios (e.g., surveillance) due to the varying image quality. In order to address the lack of low-quality images in real scenarios, we build a Low-Quality Face Anti-Spoofing Dataset (LQFA-D) by using Hikvision’s surveillance cameras. In order to deploy the model on an edge device with limited computation, we propose a lightweight FAS network based on MobileFaceNet, in which the Coordinate Attention (CA) attention model is introduced to capture the important spatial information. Then, we propose a multi-scale FAS framework for low-quality images to explore multi-scale features, which includes three multi-scale models. The experimental results of the LQFA-D show that the Average Classification Error Rate (ACER) and detection time of the proposed method are 1.39% and 45 ms per image for the low-quality images, respectively. It demonstrates the effectiveness of the proposed method in this paper.
Revisiting the Application of Ultrasonic Technology for Enhanced Oil Recovery: Mechanisms and Recent Advancements
Authors: Zhang Huan , Gao Chunyang , Zhang Hongli , Song Naijian , Cao Qiang
Published: July 2024

Ultrasonic technology, which has been receiving increasing attention from the petroleum industry, has emerged as a promising environmentally-friendly technology due to its high adaptability, simple operation, low cost, and lack of pollution; the mechanisms of this technology are clarified herein. At the same time, this paper presents a comprehensive review of the impact of ultrasound on enhanced oil recovery (EOR) by removing plugs, reducing oil viscosity, and demulsifying crude oil, while highlighting the latest advancements in this field. Lastly, this paper delves into the challenges and prospects associated with the industrial implementation of power ultrasound. The objective of this review is to provide a comprehensive overview of recent advancements, serving as a valuable reference for future investigations on ultrasound-assisted EOR. Oil field results demonstrate that oil production increased by 26.5% to 100%, water cut decreased by 5% to 96%, the success rate ranged from 75% to 90%, and the effect can last for a duration of 4 h to 12 months.