bluuebunny/crossref_metadata_2025 huggingface dataset:
GLYPROLINES AS MODULATORS OF IMMUNOREACTIVITY WITHIN CONDITIONS OF “SOCIAL” STRESS
Authors: Samotrueva M. A. , Yasenyavskaya A. L. , Bashkina O. A. , Myasoedov N. F. , Andreeva L. A.
Published: September 2019

The most important direction in the development of modern medical science is the study of protective, compensatory and pathological reactions of the organism that occur in response to various stress factors.

The aim of the study is the subsequent development of methods for pharmacological correction of these reactions. The remedies for the correction of stress-induced immunity disorders are represented by the glyprolin group – the Selank drug and the Pro-Gly-Pro peptide compound – and are of particular interest. The aim of the experiment was to study the immunomodulating effect of glyprolines on the basis of the “social stress” model.

Materials and methods. The experiment was performed on non-linear male rats aged 6-8 months. A model of a sensor contact was used as a model of the experimental “social stress”. The animals were divided into groups (n = 10): a “control” group was represented by individuals with aggressive and submissive types of behavior, formed within the conditions of the experimental “social stress” for 20 days; and 2 experimental groups in which the animals were intraperitoneally administered Selank (100 µg/kg) and Pro-Gly-Pro (100 µg/kg) against the background of the experimental “social” stress once a day for 20 days. A functional activity of the immune system was studied on the basis of standard immunopharmacological tests: a delayed-type hypersensitivity test (DTH test), a direct agglutination test (DAT), a latex test for studying the Neutrophil phagocytic rate of peripheral blood, and the essessment of the leucogram.

Results. It has been established, that within the conditions of the “social” stress, the changes in the immune response are multidirectional. That fact confirms the theory of “the immune disbalance” caused by the action of stressors. As a result of studying the effect of glyprolines within the conditions of “the social stress”, Selank and Pro-Gly-Pro proved to be effective immunocorrectors, restoring cellular and humoral immunogenesis reactions as well as the phagocytic activity of neutrophils and leucogram indices.

Сonclusion. The carried out study expands understanding of the immunoreaction pathogenesis within the stress-induced conditions in order to further develop a pharmacological strategy for correcting the revealed disorders through the substances of the neuropeptide structure.
Projetos na escola pública: a percepção dos alunos
Authors: Santos Marlene
Published: September 2019

Este artigo apresenta resultados parciais de uma pesquisa de abordagem qualitativa sobre as percepções de um grupo de estudantes do Ensino Médio da rede pública estadual de São Paulo sobre a utilização da estratégia de projetos no ensino de Filosofia. A coleta de dados foi realizada a partir da aplicação de um questionário semiestruturado a um grupo de 15 alunos, provenientes de sete diferentes turmas do terceiro ano do Ensino Médio. Os dados coletados e analisados reforçam nossa concepção, também presente em diversos estudos recentes, sobre a necessidade de maior adequação das práticas pedagógicas às necessidades e aos interesses dos educandos.
O acervo da Escola Técnica Estadual Henrique Lage como fonte de pesquisa para a história da educação fluminense
Authors: Costa Nailda Marinho da , Ignácio Sâmela Cristinne Furtado de Carvalho
Published: September 2019

O artigo trata do uso e do potencial do acervo da Escola Técnica Estadual Henrique Lage como fonte de pesquisa para a história da educação fluminense. Acervo localizado em dois espaços distintos no interior da instituição escolar: no Centro de Memória Henrique Lage e no arquivo da escola. O primeiro se constitui como um espaço de pesquisa e recuperação da memória da escola criada em 1923 como escola profissional para meninos e que hoje integra o conjunto de seis escolas técnicas centenárias da Fundação de Apoio à Escola Técnica do Rio de Janeiro; o segundo se constitui como um setor ligado à secretaria escolar que é alvo de atuação do primeiro, tendo em vista que no arquivo se encontra uma documentação produzida e acumulada pela instituição escolar desde a sua criação, portanto de valor histórico, até os dias atuais.
Professores-narradores de pessoas trans*: experiência e metodologia em Itaboraí
Authors: Brasil de Moraes Cristiano Da Silva
Published: September 2019

O que dizem professores de pessoas trans* de uma cidade na região metropolitana do Rio de Janeiro sobre sua educação, seu convívio em sala de aula e seu processo de escolarização? A partir da colaboração dos estudos de gênero e sexualidade e da história da educação e da profissão docente, as narrativas desses educadores e educadoras da cidade de Itaboraí sobre seus alunos foi registrada, dando corpo auma dissertação de mestrado. Neste texto, apontamos quais caminhos metodológicos foram tomados e comentamos parte dos discursos desses agentes da educação.
DINÂMICA DE MATÉRIA ORGÂNICA DE SUPERFÍCIE CONDICIONADA PELA TOPOGRAFIA EM FLORESTA ATLÂNTICA DE MACIÇO COSTEIRO, PARNA-TIJUCA, RJ
Authors: Miranda Felipe Soter de Mariz e , Avelar André de Souza
Published: September 2019

Em vista à importância da dinâmica de matéria orgânica para a ecologia florestal, o presente trabalho analisou a influência topografia sobre os processos de produção e estocagem de serapilheira em área de Floresta Atlântica Ombrófila pertencente ao PARNA-Tijuca, RJ. A pesquisa englobou aspectos da vegetação, a produção, redistribuição e estocagem de serapilheira, além de características do solo como presença de matéria orgânica e fertilidade. Tais variáveis foram comparadas entre as condições de divisor de drenagem, alta e baixa encostas e o fundo de vale. O divisor de drenagem destaca-se apresentando vegetação mais baixa, com dossel um pouco mais aberto, maior densidade de indivíduos e favorável às palmeiras, em comparação às demais áreas. As variações encontradas na estrutura da vegetação não se materializaram em diferenças significativas entre as posições na encosta em relação à massa de detritos orgânicos aportados ao solo durante um ano. A redistribuição de serapilheira pela topografia é essencialmente associada ao momento da queda dos detritos, e o material já depositado no solo também pode ser mobilizado para o movimento encosta abaixo. Condicionadas pelo gradiente de umidade vinculado à topografia, taxas de decomposição diferenciadas resultam em estoques de serapilheira significativamente menos espesso no fundo de vale onde a decomposição é mais rápida. O divisor de drenagem, menos úmido, apresenta estoque mais espesso. Os estoques foram similares e intermediários na alta e baixa encosta. Como provável reflexo da decomposição mais lenta da serapilheira, o divisor de drenagem apresentou pior condição de fertilidade, com alta acidez e presença de alumínio.
Liver Functional Evaluation Using Gadoxetic Acid Versus the Gold Standard Hepatobiliary Scintigraphy in Patients with Bile Duct Diseases
Authors: Shorikov M. A. , Sergeeva O. N. , Kashkadaeva A. V. , Averinova S. G. , Lapteva M. G. , Frantsev D. Yu. , Polyakov A. N. , Kudashkin N. E. , Alekhin A. P. , Moroz E. A. , Virshke E. R. , Dolgushin B. I.
Published: September 2019

Objective. To compare liver function assessments using Gd-EOB-DTPA-enhanced MRI and the gold standard hepatobiliary scintigraphy (HBS) in patients with bile duct diseases.

Material and methods. The investigation enrolled 18 patients (male/female = 11/7; age, 29–70 years, Klatskin tumor (n=16), bile duct epithelial dysplasia (n=1), intrahepatic cholangiolithiasis (n=1)) after biliary decompression, who underwent 21 paired MRIs and 99mTc-mebrofenin HBS at a study interval of no more than 3 days. In the same regions of interest with a size of 30–50 pixels located in liver segments II–III, IV, V–VIII, and VI–VII, a MRI signal was measured before MR contrast agent (MRCA) injection into the standard vascular phases and at 10, 20, 30 and 40 minutes, then the signal was expressed as a percentage of intensity compared to the precontrast series. After MR volumetry, the functional volumes of the left and right liver lobes were also defined as the area under the MRCA accumulation curve, which was multiplied by the lobe volume and expressed as a percentage of the similarly calculated function of the entire liver. Similar intensity parameters and functional volumes were estimated for a HBS study.

Results. The lobe functional volumes measured by the two methods were highly correlated (R=0.8; p<0.001) and did not show a significant difference at all when comparing with the Mann–Whitney test (p>0.3). The excretion rate of 99mTc-mebrofenin was also highly correlated with MRI findings (R=0.5–0.9; p<0.05). Conclusion. Gd-EOB-DTPA-enhanced MRI revealed a high correlation with the gold standard; however, additional studies are needed to clarify the possibilities and limitations of replacing one method with another one.><0.05).

Conclusion. Gd-EOB-DTPA-enhanced MRI revealed a high correlation with the gold standard; however, additional studies are needed to clarify the possibilities and limitations of replacing one method with another one.
Invasive Mucormycosis with Lung Involvement in a Female Patient with Aplastic Anemia
Authors: Sheikh Zh. V. , Tyurin I. E. , Sinopal’nikov A. I. , Arablinskiy A. V. , Safonova T. D. , Fedyaeva E. V. , Murav’ev O. B. , Shvayko S. N.
Published: September 2019

Mucormycosis is an infection caused by one of several types of mold. Invasive mucormycosis is the most aggressive, rapidly progressive fungal infection. The disease is characterized by high attributable mortality. The early and accurate diagnosis of invasive mucormycosis determines the choice of an adequate therapeutic policy, by improving the prognosis of the disease. The method of choice for diagnosing pulmonary mucormycosis is computed tomography that allows accurate determination of the location and extent of the lesion, the state of the lung parenchyma, and the presence of concomitant complications. The paper describes a clinical case of damage to the lung and skin in invasive mucormycosis in a 28-year-old woman with aplastic anemia. The case is of interest due to a larger number of immunocompromised patients, especially those susceptible to the disease.
Magnetic Resonance Imaging in the Differential Diagnosis of Multiple Sclerosis and Other Demyelinating Diseases
Authors: Krotenkova I. A. , Bryukhov V. V. , Konovalov R. N. , Zakharova M. N. , Krotenkova M. V.
Published: September 2019

The diagnosis of multiple sclerosis (MS) is quite complicated, which is associated with its clinical features and the lack of unique confirmatory tests. Magnetic resonance imaging (MRI) is one of the ways to confirm the diagnosis and also makes it possible to establish a differential diagnosis with other demyelinating diseases and to exclude diseases that mimic MS. This review presents not only MRI criteria for MS and other diseases similar to the MRI pattern, but also additional clinical and laboratory data, without which it is impossible to make a correct diagnosis.
Efek Jus Pisang Tongka Langit (Musa troglodytarum) Terhadap Ginjal Mencit (Mus musculus) Model Malaria
Authors: Samson Efraim , Sopacua Melati , Eddy La
Published: September 2019

High incidence of malaria cases encourage various treatments efforts including exploration of various local knowledge, related to utilization of medicinal plants. The tongka langit banana (Musa troglodytarum) is a unique and endemic plant species from Moluccas, wich based on public testimonies were belived to have ability to cure fever, hepatitis, malaria, increasing male stamina and make better kidney function. The purpose of this research was to examine the effect of tongka langit banana juice on the mice kidney (Mus musculus) of the malaria model. Twenty male mice were used which consist of 5 donor mice and 15 test mice further devided into 5 treatment groups, such as, K (+) group, K (-) group, P1 dose group with tongka langit banana intake (0,55 g/mice/day); P2 (0,65 g/mice/day); dan P3 (0,75 g/mice/day), each group consisted of 3 mice. The results showed, that feeding mice with tongka langit banana juice is effective to decreased kidney damages of mice malaria model, such as, hydropic degeneration, necrosis, and atrophy. Of the three dose given, 0,75 g/mice/day is the most effective dose.
Pengaruh Bahan Kalsium Oksida pada Waktu Pengikatan Pasta Beton Geopolimer dan Konvensional
Authors: Qomaruddin Mochammad , Umam Khotibul , Istianah Istianah , Adi Saputro Yayan , Purwanto Purwanto
Published: September 2019

Pasta geopolimer merupakan pasta dengan bahan limbah fly ash sebagai binder dan pasta konvensional merupakan pasta yang menggunakan semen sebagai bahan utama binder. Substitusi penambahan bahan limbah pada penelitian ini bertujuan untuk komparasi antara pasta geopolimer dan pasta konvensional dengan beberapa variasi limbah. Metode yang digunakan dalam penelitian ini adalah eksperimental setting time dengan prosentase variasi perbandingan binder  100% FA : 0%, 90% : 10%,  80% : 20. Aktivator 1 : 2 (NaOH dan Na2SiO3) Molaritas yang dipakai yaitu 8M dan 12M. Proses Setting time (waktu pengikatan awal) yaitu saat pencampuran binder dengan air maupun aktivator kemudian penurunan jarum terjadi setelah waktu terjadi setiap 5 menit. Dari hasil setting time dengan perbandingan pasta konvensional dan pasta geopolimer menunjukan bahwa waktu ikat awal paling cepat terjadi pada pasta geopolimer 12M penambahan gypsum 20% yaitu selama 7 menit. untuk waktu ikat awal paling cepat dengan perbandingan pasta geopolimer 8M dan 12M terjadi pada pasta geopolimer 12M. Sedangkan pada untuk pengikatan akhir terjadi paling cepat pada pasta geopolimer 12M dengan penambahan gypsum 8M yaitu selama 15 menit.
The Charcot Marie Tooth Disease Mutation R94Q in MFN2 Decreases ATP Production but Increases Mitochondrial Respiration under Conditions of Mild Oxidative Stress
Authors: Wolf Christina , Zimmermann Rahel , Thaher Osamah , Bueno Diones , Wüllner Verena , Schäfer Michael K.E. , Albrecht Philipp , Methner Axel
Published: September 2019

Charcot-Marie-Tooth disease is a hereditary polyneuropathy caused by mutations in Mitofusin-2 (MFN2), a GTPase in the outer mitochondrial membrane involved in the regulation of mitochondrial fusion and bioenergetics. Autosomal-dominant inheritance of a R94Q mutation in MFN2 causes the axonal subtype 2A2A which is characterized by early onset and progressive atrophy of distal muscles caused by motoneuronal degeneration. Here, we studied mitochondrial shape, respiration, cytosolic and mitochondrial ATP content as well as mitochondrial quality control in MFN2-deficient fibroblasts stably expressing wildtype or R94Q MFN2. Under normal culture conditions, R94Q cells had slightly more fragmented mitochondria but a similar mitochondrial oxygen consumption, membrane potential and ATP production as wildtype cells. However, when inducing mild oxidative stress 24 h before analysis using 100 µM hydrogen peroxide, R94Q cells exhibited significantly increased respiration but decreased mitochondrial ATP production. This was accompanied by increased glucose uptake and an upregulation of hexokinase 1 and pyruvate kinase M2 suggesting increased pyruvate shuttling into mitochondria. As these changes coincided with decreased levels of PINK1/Parkin-mediated mitophagy in R94Q cells, we conclude that the disease-causing R94Q mutation in MFN2 causes uncoupling of mitochondrial respiration from ATP production by a less efficient mitochondrial quality control triggered by oxidative stress.
Controlling Characteristics of the Slot Wave by Virtual Capacity Setting: LIP Solving Slot Allocation Based on Data Splitting Method
Authors: Ye ZhiJian , Zhai Wenpeng , Zheng Xinxin , Huang Shihao
Published: September 2019

Management of demand and capacity for airport operation is important. The effect of capacity setting on slot adjustment, maximum adjustment and flight delay has been extensively investigated and discussed in previous slot adjustment models. But its effect on characteristics of flight waves has not been studied deeply. At present, in order to resolve the problem that Linear Integer Programming (LIP) is limited in slot allocation due to its fast dimension growth and large memory consumption, the general practice is to optimize the slot application according to data-splitting technology. However, the relationship among data splitting method, capacity setting and characteristics of slot wave has not been investigated in detail, which limits the application of LIP in slot allocation. Through the detailed analysis and testing, we found that the waveform and amplitude of slot wave can be controlled and designed by appropriate virtual capacity settings, while the number of capacity constraints and the computing time is reduced by adopting appropriate data feeding method. Our research also provides clues for further research on the construction of the flight waves for airlines operating at specific airports in order to establish direct or indirect connectivity, and increase hit rate by using our approaches.
Sulfonated Carbon Material as An Efficient Solid Acid Catalyst for Biodiesel Synthesis via Oleic Acid Esterification Under High Voltage Conditions
Authors: Mahdavi Mohammad , Darab Amir hosein
Published: September 2019

Sulfonated carbon was used as an efficient and reusable heterogeneous solid acid catalyst for the synthesis of biodiesel via esterification of oleic acid with methanol under high voltage conditions. Using an inexpensive and reusable catalyst, environmental benignity, excellent yields in short times, synthesis in atmospheric pressure and low temperature conditions are some of the important features of this protocol. In the final results were confirmed by GC.
A Quantitative Public Health Risk Assessment Tool for Planning for At-Risk Populations
Authors: Peters Rachel , Hipper Thomas J. , Kricun Hilary , Chernak Esther
Published: September 2019

The Drexel University Center for Public Health Readiness and Communication developed a quantitative public health risk assessment tool that has been used in Pennsylvania and across the United States. The tool assesses hazard impacts on health care and public health metrics and incorporates the planning needs of at-risk populations. The flexible platform using Microsoft Excel allows planners to customize hazard assessment and use jurisdiction-specific data. Findings from the risk assessment can guide planning and evaluate preparedness progress over time.
Elbow Flexion Reanimation
Authors: Shah Neil V. , Kelly John J. , Patel Aakash M. , White Colin M. , Hausman Michael R. , Koehler Steven M.
Published: September 2019

» Restoration of elbow flexion in the setting of brachial plexopathy is crucial and can be accomplished in a number of ways. Current options include non-free muscle transfers, including tendon, nerve, and pedicled flap transfers, and free functional muscle transfers, most frequently involving transfer of the gracilis muscle.

» Currently, free functional muscle transfer is employed when all other options have been exhausted. Graft-related advantages include lack of functional deficits at the donor site, similar size of vascular structures of the gracilis to the thoracoacromial artery and cephalic vein, and contractile fibers running in parallel to the muscle’s course.

» Evidence is limited when comparing various methods of elbow flexion reanimation, particularly when evaluating free functional muscle transfers and non-free muscle transfers against each other. However, current but limited evidence appears to demonstrate favorable functional outcomes with free functional muscle transfers, although prospective studies are needed to confirm these findings.
Variación morfológica en Heterophrynus boterorum (Arachnida: Amblypygi: Phrynidae)
Authors: Vasquez Palacios Sebastian , Chirivi Joya Daniel Andres , García Hernández Andrea Lorena , Mantilla Meluk Hugo , Torrez Carrera Jhon Deiber
Published: September 2019

Se evaluó la variación morfológica de Heterophrynus boterorum con relación a su distribución geográfica, comparando poblaciones de la vertiente oriental y occidental de la cordillera Central y una población de la cordillera Oriental de los Andes, en los departamentos de Tolima y Quindío, Colombia. Mediante técnicas de estadística univariada y multivariada, (ACP, ANOVA y Kruskal-Wallis), se compararon poblaciones presentes en municipios de ambas vertientes y cordilleras. Se encontró variación entre poblaciones en 15 de 33 caracteres morfológicos examinados. La mayor variación se encontró en el tamaño de palpos, número de espinas y tubérculos. La población del municipio de Lérida se diferenció notablemente de las demás poblaciones del análisis. El resto de poblaciones formaron un grupo morfológico con amplia variabilidad, principalmente en tamaño. Heterophrynus boterorum podría considerarse como modelo de estudio para el efecto del gradiente ambiental y altitudinal de los Andes en la diversificación morfológica de los Amblypygi.
Evaluación rápida de Mamíferos en áreas de conservación de la corporación autónoma del departamento del Quindío, Colombia.
Authors: Vasquez Palacios Sebastian , Chica-Gálvis Carlos Andres , Mantilla-Meluk Hugo , Díaz-Giraldo Vanessa , Botero-Zuluaga Mariana , O. Montilla Sebastián
Published: September 2019

Se presenta el listado de los mamíferos medianos y grandes registrados en 11 áreas de conservación del departamento del Quindío, Colombia. La fase de campo se desarrolló en cinco municipios, entre julio y diciembre del 2016, y el muestreo incluyó recorridos por transectos e instalación de cámaras trampa. Se confirma la presencia de 21 especies de mamíferos en las áreas estudiadas. Las áreas con mayor número de especies hacen parte de la Reserva Forestal Central o están cerca a otras áreas de conservación, situación que podría estar permitiendo la interconexión entre reservas por corredores biológicos. Cuatro de las especies registradas se encuentran bajo categoría de amenaza: Tapirus pinchaque (En Peligro), Aotus lemurinus, Leopardus tigrinus y Mazama rufina (Vulnerable). Se resalta la presencia de Leopardus pardalis como nuevo registro para el departamento.
Diagnóstico del estado de la colección de anuros del Museo de La Salle, Bogotá, Colombia
Authors: Cárdenas Hincapie Julieth Stella , Delgadillo Méndez Diana Alexandra
Published: September 2019

La colección de anuros del Museo de La Salle es una de las más antiguas de Colombia, con 2059 especímenes recolectados desde 1917. Esa antigüedad representa un reto para cuantificar el estado de la colección de manera integral, considerando que no cumplirá necesariamente con los estándares actuales de calidad. Debido a esto, se implementó una metodología para evaluar el estado de la colección a partir de su salud, la completitud de datos, la representatividad taxonómica, la identificación taxonómica y la representatividad geográfica. Registramos 13 familias, siendo Craugastoridae la más abundante, con 44 especies y 517 especímenes. El departamento con el mayor número de especímenes es Cundinamarca, con 363 registros y 52 especies. Encontramos que la mayoría de los individuos presentan condiciones óptimas de conservación y preservación. Los resultados de esta investigación permitieron solucionar problemas de la colección, y se espera que, a partir de la metodología utilizada, el ejercicio sea de utilidad para otras colecciones.
Primer registro de leucismo en Dasyprocta fuliginosa (Dasyproctidae, Rodentia) en Ecuador
Authors: Mejía Valenzuela Edison Gabriel
Published: September 2019

El leucismo es un desorden hipopigmentario congénito que ha sido descrito en varias especies de mamíferos silvestres, como una condición anormal e inusual. Se presenta el primer registro de Dasyprocta fuliginosa con leucismo y se discuten las posibles causas de esta condición.
La organización-empresa: ¿un sistema vivo? Aportes de la teoría de la complejidad y la filosofía ambiental a la teoría administrativa y organizacional
Authors: Arias-Pineda Andrés Alberto , Ramirez-Martinez Leonardo
Published: September 2019

Rev.esc.adm.neg

La concepción de la organización-empresa como un sistema vivo, dinámico y caórdico, conformada y gestionada por cuerpos mundo-de-la-vida simbólico-biótico, emerge de preguntarse por los aportes qué hacen las teorías de la complejidad y la filosofía ambiental a las teorías administrativas y organizacionales; es decir por cuestionar la posibilidad de reconfigurar las lógicas administrativas, que se hallan en una crisis estructural, a partir de la perspectiva epistémica complejo-ambiental o por la necesidad de entender qué significa gestionar organizaciones sociales vivas.  En otras palabras, surge como una propuesta para comprender el fenómeno administrativo-organizacional en tiempos de sociedad de organizaciones y crisis ambiental e implica comprender la organización social tipo taxis como un sistema social vivo que establece entramadas relaciones con su entorno, afectando el desarrollo de sus operaciones y procesos.

La vitalidad de estos sistemas deviene de sus redes informales, de su cultura organizacional, de la posibilidad de flexibilizar sus estructuras y sus procesos, y de su clausura referencial. 

El texto se despliega en dos rutas de trabajo. El primer trayecto pretende comprender la relación entre los problemas civilizatorios actuales, y la institucionalización del pensamiento administrativo clásico en la sociedad. El segundo intenta aportar en la discusión epistémica en el campo de las Teorías Organizacionales y Administrativas, desde el lente teórico de las Teorías de la Complejidad y el Caos, y la Filosofía Ambiental.
Efectos de las buenas prácticas en el valor de marca de las universidades chilenas
Authors: León Mauricio , Améstica-Rivas Luis , King-Domínguez Andrea , Gurrola Cesar
Published: September 2019

Rev.esc.adm.neg
El presente artículo tiene como objetivo valorar financieramente las marcas de las 58 universidades chilenas, creando un ranking de desempeño e identificando las principales variables que inciden en su valor. Para estos efectos, se utiliza una adaptación del método de múltiplos de valoración de empresas en base a los estados financieros de las instituciones para el período 2012 - 2015, un análisis factorial de componentes principales y una regresión lineal múltiple a partir de variables institucionales. 
Como resultados principales se establece que un 88 % de las universidades pose un valor de marca positivo, destacando las dos universidades líderes del país. Estos resultados son coincidentes con rankings de calidad y reputación, existiendo una correlación positiva entre el valor de marca y los rankings. Los determinantes del valor de la marca son la calificación del cuerpo académico, dada por su nivel de postgraduación, y la infraestructura institucional.
Aunque el valor de marca en la educación superior ha recibido atención académica en los últimos años, encontrar un mejor método para determinar su valor y las dimensiones que lo explican no está exento de cuestionamientos. Sin embargo, avanzar empíricamente es un reflejo de la inquietud científica de una dimensión poco estudiada como es la perspectiva económica – financiera. Se pretende, por tanto, que los resultados puedan servir de apoyo a los gestores universitarios, al poder descifrar las variables que contribuyen favorablemente en el valor de su marca y, por ende, generar estrategias adecuadas para fortalecerla o mantenerla en el tiempo.
Integrated Reservoir Characterization and Simulation to Optimize Recovery from a Mature Carboniferous North Sea Gas Field with Water Influx
Authors: Weijermans Peter-Jan , Huibregtse Paul , Arts Rob , Benedictus Tjirk , De Jong Mat , Hazebelt Wouter , Vernain-Perriot Veronique , Van der Most Michiel
Published: September 2019

The E17a-A gas field, located offshore The Netherlands in the Southern North Sea, started production in 2009 from Upper Carboniferous sandstones, initially from three wells. Since early production history of the field, the p/z plot extrapolation has consistently shown an apparent Gas Initially In Place (GIIP) which was more than 50% higher than the volumetric GIIP mapped. The origin of the pressure support (e.g. aquifer support, much higher GIIP than mapped) and overall behavior of the field were poorly understood.

An integrated modeling study was carried out to better understand the dynamics of this complex field, evaluate infill potential and optimize recovery. An initial history matching attempt with a simulation model based on a legacy static model highlighted the limitations of existing interpretations in terms of in-place volumes and connectivity. The structural interpretation of the field was revisited and a novel facies modeling methodology was developed. 3D training images, constructed from reservoir analogue and outcrop data integrated with deterministic reservoir body mapping, allowed successful application of Multi Point Statistics techniques to generate plausible reservoir body geometry, dimensions and connectivity.

Following a series of static-dynamic iterations, a satisfying history match was achieved which matches observed reservoir pressure data, flowing wellhead pressure data, water influx trends in the wells and RFT pressure profiles of two more recent production wells. The new facies modeling methodology, using outcrop analogue data as deterministic input, and a revised seismic interpretation were key improvements to the static model. Apart from resolving the magnitude of GIIP and aquifer pressure support, the reservoir characterization and simulation study provided valuable insights into the overall dynamics of the field – e.g. crossflows between compartments, water encroachment patterns and vertical communication. Based on the model a promising infill target was identified at an up-dip location in the west of the field which looked favorable in terms of increasing production and optimizing recovery. At the time of writing, the new well has just been drilled. Preliminary logging results of the well will be briefly discussed and compared to pre-drill predictions based on the results of the integrated reservoir characterization and simulation study.

The new facies modeling methodology presented is in principle applicable to a number of Carboniferous gas fields in the Southern North Sea. Application of this method can lead to improved understanding and optimized recovery. In addition, this case study demonstrates how truly integrated reservoir characterization and simulation can lead to a revision of an existing view of a field, improve understanding and unlock hidden potential.
Polymorphism of MUC1 gene in Vietnamese gastric cancer patients: a case-control study
Authors: Nguyen Lan Thi Ngoc , Dang Dzung Thi Ngoc , Ta Van Thanh , Dang Huy Quang , Tran Chuc Van , Yamaguchi Masamitsu
Published: September 2019

Background Gastric cancer is a malignant type of cancer associated with many factors such as environment, behavior, infection, and genetics, which include Single Nucleotide Polymorphism. A few studies revealed polymorphisms of the Mucin 1 gene have a role and significance as a susceptible factor contributing to gastric cancer. The aim of this research is to evaluate the association between Single Nucleotide Polymorphisms of the Mucin 1 gene and Vietnamese gastric cancer patients.Methods 302 gastric cancer patients and 304 controls were interviewed for social-economic characteristics, smoking and drinking status, personal and family history of gastric diseases. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism analysis. The association of Single Nucleotide Polymorphisms with gastric cancer was evaluated using multifactor regression models.Results AA genotype for rs4072037 was found to be highly associated with gastric cancer (OR: 2.07 (95% CI: 1.46-2.90). GG genotype for rs2070803 increased the risk of gastric cancer (OR:1.96 (95% CI: 1.37-2.78). These genotypes in combination with other factors such as old age, male gender, alcoholism and personal history of gastric disease also showed an increased risk of having gastric cancer.Conclusions rs4072037 and rs2070803 of Mucin 1 genes are two genotypic risk factors of gastric cancer. Those in combination with other factors such as gender, family history, smoking and drinking habits significantly increase the risk of gastric cancer.
Relationship of lymphovascular invasion with lymph node metastasis and prognosis in superficial esophageal carcinoma: Systematic review and meta-analysis
Authors: Yang Jinxin , Lu Zhouyi , Wang An , Tan Yulong , Zhang Dekang
Published: September 2019

Background:The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esophageal carcinoma (SEC) remains unclear.Methods:We searched Embase, PubMed, Web of Science, and Cochrane Library databases for prospective articles to better understand the relationship between LVI, LNM, and SEC diagnosis.Results:We included 28 articles containing data for 5041 patients (range: 29-498) in our meta-analysis. The hazard ratio between LVI and overall survival (OS) was 1.62 with 95% confidence interval (CI) (1.17-2.26; p = 0.004) and the odds ratio between LVI and LNM was 5.7 with 95% CI (4.43-7.33; p < 0.0001). LVI in patients diagnosed with SEC results in a poor OS rate and a higher rate of LNM.Conclusions:The results indicate that LVI plays a dominant role in the prognosis of LNM in SEC and in the prognostic prediction for SEC.Keywords: Lymphovascular invasion; lymph node metastasis; prognosis; superficial esophageal carcinoma
Determinants of Undernutrition among Children Under-Five Years Old in Southern Ethiopia: Does Pregnancy Intention Matter? A Community-Based Unmatched Case-Control Study
Authors: Shaka Mohammed Feyisso , Woldie Yetayal Birhanu , Lola Hirbaye Mokona , Olkamo Kalkidan Yohannes , Anbasse Adane Tesfaye
Published: September 2019

Background Stunting, which describes a small height for one’s age, is an indicator of chronic malnutrition. It develops mainly as a result of prolonged food deprivation or a chronic disease or illness. Unintended pregnancies and unplanned births are among the psychological factors that negatively affect the nutritional status of children. Therefore, this study aimed to determine the effects of unintended pregnancies and other family and child characteristics on the nutritional status of children under 5 years old. Methods A community-based unmatched case-control study was conducted among 302 children (151 cases and 151 controls) 6–59 months old in Wonago town, Gedeo Zone, SNNPR, Ethiopia. The cases were randomly selected from among the stunted children, and the controls were randomly selected from among the non-stunted children. The descriptive characteristics of the respondents were compared using the chi-squared test, and a multivariable logistic regression was used to assess the effects of an unintended pregnancy on stunting, after controlling for the other variables, with a p value of 0.05. Results The result revealed that unintended pregnancy is found to be among predictors of stunting where children from unintended pregnancy were about three times more likely to be stunted [AOR: 2.62, CI: (1.26, 5.45)]. The other predictors identified in this study were educational status of the father, wealth index of the household and daily meal frequency. From the finding, children from illiterate fathers [AOR: 3.43, CI: (1.04, 11.29)], children from poorer household economic status [AOR: 2.32, CI: (1.20, 4.49)] and children whom their daily meal frequency is below the recommended number of feeding [AOR: 4.50, CI: (1.31, 15.49)] were found to be more stunted. Conclusions Based on the results of this study, the children born from unintended pregnancies exhibited a significantly higher risk of stunting. Therefore, preventing unintended pregnancy could play a great role in decreasing the risk of stunting in children.
Periodontal disease status and treatment need among a Kurdish population in Sulaimani/ Iraq as assessed by CPITN index.
Authors: Gul Sarhang
Published: September 2019

Background This study identifies the prevalence and severity of periodontal diseases in a given population of Sulaimani using the Community Periodontal Index of Treatment Needs (CPITN) and attempts to find the relation of CPITN with age, sex, location, visit to dentist, tooth brushing, use of mouth wash and interdental aids, systemic disease, smoking status and missing teeth.Methods Subjects attending Periodontics clinics at College of Dentistry, University of Sulaimani were examined. Periodontal examinations were performed using CPITN, plaque index (PI) and bleeding index (BI). Other data including location, visit to dentist, tooth brushing, use of mouth wash and interdental aids, presence of systemic diseases, smoking status and missing teeth were also collected. The data were subjected to logistic regression to find a relation between periodontal status (CPITN ≥ 3 or not as dependent variable) and other variables.Results Among the 1354 subjects (mean age 30.8 ± 12.9 years) examined, 43.6% were male and the majority of these (80.9%) were from urban areas. The mean PI and BI were 0.64±24 and 0.39±0.28, respectively. Calculus was the most prevalent highest score amongst examined subjects (62.2%), followed by shallow pocket (22.2%) and bleeding (9%). Among the sextants, lower central sextants were found to have the highest percentage of calculus (73.1%), followed by lower left (49.7%) and lower right (48.7%). The highest percentages of shallow and deep pockets were found at upper left (14%, 2.5%, respectively) and upper right (11.4%, 3.2%, respectively) sextants. Logistic regression analysis showed that age, sex, frequency of brushing and smoking significantly correlated with CPITN scores.Conclusion Prevalence and severity of periodontal diseases are high in the examined population and at population level age, sex, brushing and smoking were shown to have an impact on periodontal condition.
The different dietary sugars modulate the composition of the gut microbiota in honeybee during overwintering
Authors: Wang Hongfang , Liu Chunlei , Liu Zhenguo , Wang Ying , Ma Lanting , Xu Baohua
Published: September 2019

Background: The health of honeybee colonies is critical for bee products and agricultural production, and colony health is closely associated with the bacteria in the guts of honeybees. Although colony loss in winter is now the primary restriction in beekeeping, the effects of different sugars as winter food on the health of honeybee colonies are not well understood. Therefore, in this study, the influence of different sugar diets on honeybee gut bacteria during overwintering was examined.
Methods: The bacterial communities in honeybee midguts and hindguts before winter and after bees were fed honey, sucrose, and high-fructose syrup as winter-food were determined by targeting the V4 region of 16S rDNA using the Illumina MiSeq platform.
Results: The dominant microflora in honeybee guts were the phyla Proteobacteria (63.17%), Firmicutes (17.61%; Lactobacillus, 15.91%), Actinobacteria (4.06%; Bifidobacterium, 3.34%), and Bacteroidetes (1.72%). The dominant taxa were conserved and not affected by season, type of overwintering sugar, or spatial position in the gut. However, the relative abundance of the dominant taxa was affected by those factors. In the midgut, microbial diversity of the sucrose group was higher than that of the honey and high-fructose syrup groups, but in the hindgut, microbial diversity of the honey and high-fructose groups was higher than that in the sucrose group. Sucrose increased the relative abundance of Actinobacteria (Bifidobacteriales Bifidobacteriaceae) and Alphaproteobacteria (Rhizobiales and Mitochondria) of honeybee midgut, and honey enriched the Bacteroidetes and Gammaproteobacteria (Pasteurellales) in honeybee hindgut. Hgh-fructose syrup increased the relative abundance of Betaproteobacteria (Neisseriales: Neisseriaceae) of the midgut.
Conclusion: The type of sugar used as winter food affected the relative abundance of the dominant bacterial communities in honeybee guts, not the taxa. which could affect the health and safety of honeybee colonies during overwintering. The presence of the supernal Alphaproteobacteria, Bifidobacteriales, and Lactobacillaceae in the gut of honeybees fed sucrose and cheaper than honey both indicate that sucrose is very suitable as the overwintering food for honeybees.
Physical integrity of three Long-Lasting Insecticidal Net products 30 months after a mass-distribution campaign in Benin
Authors: AHOGNI Idelphonse Bonaventure , Gnanguenon Virgile , Sovi Arthur , Salako Albert Sourou , Azondekon Roseric , Dagnon Jean-Fortuné , Attolou Roseline H. , Gnanvi Janyce J. , Akinro Bruno , Yovogan Boulais , Sominahouin André Aimé , Nwangwu Udoka C , Tokponnon Filémon , Padonou Gil Germain , Akogbeto Martin Codjo
Published: September 2019

Abstract
Background
The effectiveness of long-lasting insecticidal nets (LLINs) mainly relies on their physical integrity, an important indicator of the LLINs durability in households. The present study aims to assess this physical integrity for three widely used LLIN products: DawaPlus®2.0, PermaNet®2.0 (polyester) and DuraNet® (polyethylene), distributed in Benin during the mass campaign of 2014.
Methods
The study was conducted from October 2014 to June 2017 in three districts of Benin: Tori-Bossito, Toffo, and Ouesse. Nine hundred LLINs (a cohort of 300 LLINs per product) in use and found hanging on sleeping materials were selected and tagged. Every six months, the LLIN attrition and their physical condition was monitored. The holes were counted by category allowed to calculate the proportionate hole index (pHI) and classify the LLINs into "good ", "serviceable" or "torn" categories. Factors associated with loss of integrity have also been identified following World Health Organization Guidelines.
Results
After 30 months of use, 55.9% (n= 503; 95% CI: 52.6-59.2) of the LLINs were lost. Attritions due to physical damage were similar between the LLIN products and were respectively 28.3% for PermaNet® 2.0, 29.7% for DawaPlus® 2.0, and 31% for DuraNet® (p˃0.05). The mean pHI was significantly higher for DuraNet® LLINs (pHI= 1431) than DawaPlus® 2.0 (pHI =366) and PermaNet® 2.0 (pHI =321) (<0.001). A significant difference was also observed between the proportion of LLINs in “torn” condition and included 8.7% of PermaNet® 2.0, 14.3% of DawaPlus® 2.0, and 34.1% of DuraNet® (p <0.001). The use of LLINs every night, the frequency of washing and other factors were significantly associated with the physical damage of the LLINs (p <0.001).
Conclusion
These results suggest that the physical barrier conferred by the LLIN can be significantly affected during the normal course of its use depending on the type of product distributed. National malaria programs must, therefore, consider the physical integrity performance in local conditions in the choice of LLIN product to be distributed.
Keywords: LLINs, physical integrity, pHI, malaria, Benin.
Molecular analysis of prothrombotic gene variants in venous thrombotic diseases. Different risk factors in different sex and clinical forms.
Authors: Cernera Gustavo , Amato Felice , Elce Ausilia , Liguori Renato , Bruzzese Dario , Lullo Antonella Miriam Di , Castaldo Giuseppe , Zarrilli Federica , Comegna Marika
Published: September 2019

Background The role of prothrombotic gene variants as risk factors for venous thrombotic diseases is controversial and the ordering of tests for thrombophilia in the clinical context is scarcerly respective of evidence-based data. Methods We studied FVL, FVR2, FII G20210A, MTHFR C677T and A1298C, beta-fibrinogen -455 G>A, FXIII V34L, HPA-1 L33P variants and PAI-1 4G/5G alleles in: 343 patients with deep vein thrombosis (DVT), 164 with pulmonary embolism (PE), 126 with superficial vein thrombosis (SVT), 118 with portal vein thrombosis (PVT), 75 with cerebral vein thrombosis (CVT), 119 with retinal vein thrombosis (RVT) in comparison with 430 subjects from the general population (GP) of the same geographical area (Southern Italy). Results About 40% of patients with DVT, PE and SVT have a prothrombotic predisposition represented by FVL, FVR2 and FII G20210A variants (significantly more frequent than in the general population), significantly higher in PE males. While, in patients with PVT and CVT only FII G20210A variant is more frequent particularly in females. Finally, RVT is poorly related to prothrombotic risk factors, confirming that local vascular and other factors have a pivotal role in its pathogenesis. Conclusions Our data indicate that only FVL, FVR2 and FII G20210A are related to vein thrombotic diseases while all the other gene variants, frequently ordered in the clinical context, do not have a role as risk factors. Furthermore, the evidence of a sex difference for some variants, once confirmed in larger populations, may help to promote sex-specific prevention of such diseases.
A comprehensive bioinformatics analysis Young-Aged Coronary Heart Disease
Authors: Liao Xinxue , Zhong Xiang-bin , Zhou Hua-qiang , Zhang Shao-Zhao , Zhou Hui-min , Sun Xiu-ting , Huang Man , Yang Da-ya , Guo Yue , Xiong Zhen-yu , Zhuang Xiao-dong , Liao Xin-xue
Published: September 2019

Background Coronary heart disease (CHD) is a leading cause of morbidity and mortality worldwide[1]. Although effective primary and secondary prevention successfully reduced the mortality of CHD, morbidity and mortality of young aged coronary heart disease (YA-CHD) didn’t decrease. However, little is known about the prevalence and mechanism of YA-CHD.Methods Dataset GSE 12288 from Gene Expression Omnibus was imported and performed comprehensive bioinformatics analysis, including gene ontology analysis (GO analysis), pathway analysis, protein-protein interaction network (PPI) analysis and core network analysis.Results RAP1A, which regulates platelet integrin activation and has a critical role in platelet production, was significantly up regulated, while TNKS2, which keeps the integrity of the leukocyte telomere structure and shows a significant association with longevity, was significantly downregulated. Biological process analysis showed “phagosome” pathway was mostly significant related to YA-CHD. Innate immune response module and type I interferon signaling module, interacts with IRF1, may major in the regulation of YA-CHD progression and maybe the potential therapeutic target of YA-CHD.Conclusions RAP1A and TNKS2 in peripheral leukocytes may serve as novel biomarkers in predicting the onset of YA-CHD. Further studies about weather IRF1 influence YA-CHD through regulating innate immune type I interferon signaling pathway was needed.