bluuebunny/crossref_metadata_2025 huggingface dataset:
NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome
Authors: Zhao Xiaonan , Kotch Chelsea , Fox Elizabeth , Surrey Lea F. , Wertheim Gerald B. , Baloch Zubair W. , Lin Fumin , Pillai Vinodh , Luo Minjie , Kreiger Portia A. , Pogoriler Jennifer E. , Linn Rebecca L. , Russo Pierre A. , Santi Mariarita , Resnick Adam C. , Storm Phillip B. , Hunger Stephen P. , Bauer Andrew J. , Li Marilyn M.
Published: January 2021

PURPOSE

Neurotrophic tyrosine receptor kinase (NTRK) fusions have been described as oncogenic drivers in a variety of tumors. However, little is known about the overall frequency of NTRK fusion in unselected pediatric tumors. Here, we assessed the frequency, fusion partners, and clinical course in pediatric patients with NTRK fusion–positive tumors.

PATIENTS AND METHODS

We studied 1,347 consecutive pediatric tumors from 1,217 patients who underwent tumor genomic profiling using custom-designed DNA and RNA next-generation sequencing panels. NTRK fusions identified were orthogonally confirmed.

RESULTS AND DISCUSSION

NTRK fusions were identified in 29 tumors from 27 patients with a positive yield of 2.22% for all patients and 3.08% for solid tumors. Although NTRK2 fusions were found exclusively in CNS tumors and NTRK1 fusions were highly enriched in papillary thyroid carcinomas, NTRK3 fusions were identified in all tumor categories. The most canonical fusion was ETV6-NTRK3 observed in 10 patients with diverse types of tumors. Several novel NTRK fusions were observed in rare tumor types, including KCTD16-NTRK1 in ganglioglioma and IRF2BP2-NTRK3 in papillary thyroid carcinomas. The detection of an NTRK fusion confirmed the morphologic diagnosis including five cases where the final tumor diagnosis was largely based on the discovery of an NTRK fusion. In one patient, the diagnosis was changed because of the identification of an ETV6-NTRK3 fusion. One patient with infantile fibrosarcoma was treated with larotrectinib and achieved complete pathologic remission.

CONCLUSION

NTRK fusions are more frequently seen in pediatric tumors than in adult tumors and involve a broader panel of fusion partners and a wider range of tumors than previously recognized. These results highlight the importance of screening for NTRK fusions as part of the tumor genomic profiling for patients with pediatric cancer.
Extracardiac Intrapericardial Mass Impersonating as Left Atrial Mass: Echocardiographic Perspectives
Authors: Murukendiran Gopalswamy Jayaraj , Babu Saravana , Gadhinglajkar Shrinivas V. , Sreedhar Rupa , Palaniswamy Nithiyanandhan , Pillai Vivek
Published: January 2021

Extracardiac intrapericardial masses arising posterior to left atrium (LA) often mimic an intracardiac LA mass on echocardiography. Although transthoracic echocardiography (TTE) is the primary screening tool to detect any cardiac mass, transesophageal echocardiography (TEE) is proven superior to TTE in delineating the size, morphology, and exact site of origin of LA masses. We report a case, where the preoperative TTE diagnosed an LA mass which was later confirmed to be an extracardiac intrapericardial mass by cardiac magnetic resonance imaging and intraoperative TEE. The mass was compressing the LA, and the timely diagnosis avoided the opening of the LA for mass excision.
Outcomes of secondary autologus dermo-fat orbital implants in anophthalmic sockets
Authors: Hayat Nausheen , Jan Saad , Atiq Natasha , Cheema Alyscia
Published: January 2021

Objectives: To evaluate the outcomes of secondary autologous dermis-fat graft as an orbital implant in anophthalmic sockets.

Methods: In this prospective study, which was conducted at Jinnah Post Graduate Medical Centre, Karachi, between January 2015 and January 2020, we evaluated 12 patients between the ages of four and 60 years. Most of the adults were victims of trauma, whereas children were known cases of retinoblastoma or trauma and all underwent enucleation. All of them were primarily treated elsewhere and not offered primary orbital implants. We performed autologous dermis-fat graft as an orbital implant in these patients harvesting graft from gluteal region and followed them up to look for complications.

Results: Out of 12 patients two went into failure, while rest of the patients showed successful outcome. All patients underwent successful surgery. Initially, a silicon conformer was placed, which was later on replaced with artificial prosthetic eye.

Conclusion: Regardless of the small sample size, this procedure proved to be a safe and effective method for augmenting orbital volume in anophthalmic sockets in children and adults.

doi: https://doi.org/10.12669/pjms.37.2.3209

How to cite this:Hayat N, Jan S, Atiq N, Cheema A. Outcomes of secondary autologus dermo-fat orbital implants in anophthalmic sockets. Pak J Med Sci. 2021;37(2):426-431. doi: https://doi.org/10.12669/pjms.37.2.3209

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Niat Konsumen menggunakan Transportasi Ride-Hailing di tengah Pandemi COVID-19: Kerangka Kerja Konseptual dan Evaluasi Empiris
Authors:   Universitas Muhammadiyah Palopo, Sulawesi Selatan, Indonesia, Hamid Rahmad Solling
Published: January 2021

Abstrak. Moda transportasi berbasis teknologi digital ride-hailing merupakan salah satu bisnis transportasi yang masih bisa bertahan dalam kondisi pandemi COVID-19. Di Indonesia layanan ini tidak sepenuhnya di non aktifkan tetapi hanya membatasi beberapa fitur layanan yang disesuaikan dengan protokol penangan COVID-19. Penelitian ini bertujuan untuk menguji pengaruh attitude, customer satisfaction, trust, dan subjective knowledge terhadap continuance intention pada jasa ride-hailing selama periode Pembatasan Sosial Berskala Besar (PSBB). Dengan pertimbangan jumlah keseluruhan dari populasi dalam penelitian ini tidak diketahui, maka sampel diambil menggunakan sampel non probabilitas dan diperoleh jumlan sampel sebanyak 225 responden pengguna layanan ride-hailing. Pengujian hipotesis menggunakan teknik Strukktural Equation Model. Berdasarkan hasil penelitian trust berpengaruh signifikan terhadap attitude, customer satisfaction berpengaruh signifikan terhadap trust, konstruk trust secara langsung maupun tidak langsung berdampak signifikan terhadap continuance intention yang dimediasi oleh attitude, customer satisfaction secara langsung maupun secara tidak langsung memiliki dampak positif signifikan terhadap attitude melalui trust, attitude berpengaruh signifikan terhadap continuance intention, customer satisfaction secara langsung secara tidak langsung memiliki dampak signifikan pada continuance intention yang dimediasi attitude serta trust, dan subjective knowledge berpengaruh signifikan terhadap continuance intention. Selanjutnya Hasil penelitian ini memberikan dukungan empiris terhadap Theory of Reasoned Action dengan menambahkan konstruk trust, subjective knowledge, dan customer satisfaction pada model penelitan. Dimana dari ketujuh hipotesis yang diajukan keseluruhannya dapat diterima. Kata kunci: Trust, attitude, subjective knowledge, customer satisfaction, continuance intention
Editor's Preface
Authors: Talviste Katre
Published: January 2021

Editor's Preface
“The Scar Will Always Be There”: The Post-Soviet Melancholia in Gundega Repše’s Novel 'Conjuring Iron'
Authors: Ostups Artis
Published: January 2021

The article discusses the cultural and narratological aspects of melancholic understanding of history in postmodern Latvian fiction. The first part of the study offers a brief overview of Latvian fiction of the 1990s and early 2000s with a special attention to the interrelated questions of history, trauma, and representation. The second part shifts from cultural contextualization to defining melancholic temporality and highlighting narrative ways of expressing it in fiction which addresses trauma, collective and individual, from a posttraumatic place in time. The third part analyzes the indirect and disjointed engagement with Soviet occupation in Gundega Repše’s novel Conjuring Iron (2011). This is done by focusing on the poetics of unnarrated as a sign of prolonged mourning and by thinking about the epistemology of a fragment.
When Books Speak of Books: G. Radvilavičiūtė’s Intertextuality
Authors: Cerri Adriano
Published: January 2021

The present article will analyze the intertextual dimension in the work of the Lithuanian essayist G. Radvilavičiūtė, especially focusing on her most successful book, Šiąnakt aš miegosiu prie sienos. In the introduction a brief review of U. Eco’s ideas on intertextuality will be presented, paying special attention to the notions of metafiction, dialogism, double coding, and intertextual irony. Within this theoretical framework, the main intertextual strategies used in Radvilavičiūtė’s book are examined in the core of the study. Particular attention will be paid to dialogism; for this strategy a detailed classification based on the two parameters of target and modality will be proposed. Then a peculiar kind of intertextuality is presented: while the author frequently makes a conscious and obvious use of references to other texts, I will suggest that it could also be possible to find traces of unconscious “intertextual echoes”. To demonstrate this, some similarities with V. Nabokov’s novel Laughter in the Dark are discussed. Such similarities could be due to an unconscious influence of this novel on the author (in this case they would be “echoes”), or to pure coincidence. In both cases, however, this is an interesting instance of hermeneutic cooperation between the author and the reader. Far from diminishing Radvilavičiūtė’s flourishing creativity, these considerations reinforce the idea that any open text calls for the addressee’s cooperation. Hence, the reader not only decodes intertextuality, but also actively creates a net of references that sometimes go beyond the author’s (conscious) intentions.
L’essence éthique du dialogue culturel
Authors: Franek Ladislav
Published: January 2021

The ethical essence of cultural dialogue. The definition of comparative literary studies in Slovakia. Historical poetics in the works of D. Ďurišin, focused on the typological essence of literary phenomena on the basis of interrelating theoretical and developmental aspects of national literature. The differences of Slovak methodology from Western positivist models of the study of interliterariness. Parallel existence of the principles of literary history and criticism in the reception analyses of Russian, German and French literatures by older Slovak scholars. The onset of realism in Slovak literature at the end of the 19th century (S. Hurban Vajanský). The important contribution of J. Felix’s critical reflection of universalist tendencies in European and esp. modern French writing. The complexity of organically incorporating these impulses into the context of Slovak literature as a result of the provincial character of a “small” nation. The wealth of translations from contemporary world literatures and its positive impact on the work of many Slovak writers in spite of the discontinuity of research in this area after 1989. Urgent need to return to similar forms of literary-cultural reflection and self-reflection through reviving an intensive philological, linguistic, theoretical-critical and historical study at our universities.
The Relevance of the Reading Process in the Context of Estonian Literary Criticism
Authors: Soosaar Susanna
Published: January 2021

The importance of the reading experience has been accepted in literary studies ever since the advent of reading-response theories in the 1970s-1980s. Several notable scholars have stressed that meaning is created through the interaction between reader and text, highlighting the significance of the reader. Even though the main principles of reader-response have become commonplace, for some time, reading theories remained relatively stagnant. In the 2000s, however, the topic of reading was rediscovered as new perspectives for examining the reading experience and the reader’s relationship with the text were offered. These new theories shed new light on the figure of the reader and on the work that goes into the process of reading. While the question of the experience of reading has been under discussion in the Anglo-American context, it has never been widely discussed in Estonia. The purpose of this article is to give an overview of well-known reader-response theories that became popular in the 1970s. In addition, examples of a renewed interest in reader-response theories in recent decades are presented. Finally, the article will also examine how Estonian-language literary criticism has engaged with reader-response theories.
Albanian Literature in Its Critical Evaluation Process. Case Study: Periodicals
Authors: Kërbizi Marisa , Macaj Edlira
Published: January 2021

The aim of this article is to analyze the process of evaluation of Albanian literature in literary periodicals (print or online). The research aims to explain the nature of criticism of Albanian literature in accordance with three main periods of Albanian literary history (1920–1944; 1945–1990; 1991–present). The paper has a short chronological presentation of the main periodicals which deal with literature. It also deals with the reception of Albanian literature in old and new periodicals. Some of the most important research questions of this paper are: Is there a continuation in the critical approaches to Albanian literature from the beginning to the present? Do critics have a ‘critical’ interaction between them while they express their evaluation regarding literature? Who are the critics? Which is the core role of certain critics and periodicals? The methodology used in this paper embraces a historical, analytical, statistical and interpretative approach. The paper will be developed in two parallel sections. The first one will elaborate quantitatively official data related to the number of periodicals which deal with the evaluation of literature in its theoretical and critical aspects and the other section will describe, analyze and interpret the data. The research results tend to prove that the process of critical evaluation of Albanian literature has experienced similar characteristics with Albanian literature itself. The critical reflection or criticism has turned out to be a refracting process. The critical evaluations are marred occasionally by low levels of professionalism or political interference.
Reconstruction of a Mangled Hand with a Thoracodorsal Artery Perforator Free Flap: A Report of Two Cases
Authors: Park Hyun Sik , Kim Dong-Jin , Hwang Joing Ick
Published: January 2021

Mangled hands are a severely injured condition that is a rare and challenging problem for reconstructive surgeons. Surgical flaps such as anterolateral thigh, radial forearm, or thoracodorsal artery flaps have been used for multiple-digit resurfacing. In this report, we describe two cases of complex defects that included multiple digits in patients who underwent reconstruction with thoracodorsal artery perforator (TDAP) free flaps. All massive soft tissue defects were completely covered with a TDAP free flap. The thinner perforator flap could be harvested, and the patients regained the ability to pinch and grasp. Therefore, the authors present two cases of mangled hands successfully treated with TDAP free flap.
TM-polarized angle-dispersive metasurface for axisymmetric extension of beam steering angles
Authors: Li Ying , Xu Lijin , Yang Jun , Deng Guangsheng , Yin Zhiping , Li Xiangxiang , Wang Xiong
Published: January 2021

Axisymmetric extension of beam steering angles by metasurfaces is of great interest due to its potential application in extending the angular scan range of existing phased arrays. This angle-multiplexed manipulation functionality requires anti-symmetrically angle-dispersive phase gradient, as well as anti-symmetric angular phase dispersion over continuous incident angles, which is difficult to be implemented by existing metasurfaces. In this work, a series of meta-atoms with asymmetric structures are developed to achieve the required phase response. Based on the asymmetric meta-atoms, an angle-dispersive metasurface for axisymmetric beam steering of transmitted transverse-magnetic (TM) wave is designed, fabricated and tested, whose simulation and experimental results demonstrate the axisymmetric extension capability of beam steering angles from -53° ≤ θi ≤ 53° to almost -90° ≤ θt ≤ 90°.
UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin
Authors: Saini Natalie , Giacobone Camille K. , Klimczak Leszek J. , Papas Brian N. , Burkholder Adam B. , Li Jian-Liang , Fargo David C. , Bai Re , Gerrish Kevin , Innes Cynthia L. , Schurman Shepherd H. , Gordenin Dmitry A.
Published: January 2021

Human skin is continuously exposed to environmental DNA damage leading to the accumulation of somatic mutations over the lifetime of an individual. Mutagenesis in human skin cells can be also caused by endogenous DNA damage and by DNA replication errors. The contributions of these processes to the somatic mutation load in the skin of healthy humans has so far not been accurately assessed because the low numbers of mutations from current sequencing methodologies preclude the distinction between sequencing errors and true somatic genome changes. In this work, we sequenced genomes of single cell-derived clonal lineages obtained from primary skin cells of a large cohort of healthy individuals across a wide range of ages. We report here the range of mutation load and a comprehensive view of the various somatic genome changes that accumulate in skin cells. We demonstrate that UV-induced base substitutions, insertions and deletions are prominent even in sun-shielded skin. In addition, we detect accumulation of mutations due to spontaneous deamination of methylated cytosines as well as insertions and deletions characteristic of DNA replication errors in these cells. The endogenously induced somatic mutations and indels also demonstrate a linear increase with age, while UV-induced mutation load is age-independent. Finally, we show that DNA replication stalling at common fragile sites are potent sources of gross chromosomal rearrangements in human cells. Thus, somatic mutations in skin of healthy individuals reflect the interplay of environmental and endogenous factors in facilitating genome instability and carcinogenesis.
Validity and precision of the International Physical Activity Questionnaire for climacteric women using computational intelligence techniques
Authors: Ferreira Freitas Ronilson , Santos Brant Rocha Josiane , Ives Santos Laercio , de Carvalho Braule Pinto André Luiz , Rodrigues Moreira Maria Helena , Piana Santos Lima de Oliveira Fernanda , Marques Maria Suzana , Souza Guerra Júnior Geraldo Edson , de Oliveira Silva Guerra Kelma Dayana , Araújo Drummond Andreia Maria , Villas Boas Spelta João Victor , Ananias Meira Trovão Carolina , Schmidt França Dorothéa , Borges Oliveira Lanuza , Prates Caldeira Antônio , Silveira Vasconcelos D’Angelo Marcos Flávio
Published: January 2021

This study aimed to evaluate the validity and precision of the International Physical Activity Questionnaire (IPAQ) for climacteric women using computational intelligence techniques. The instrument was applied to 873 women aged between 40 and 65 years. Considering the proposal to regroup the set of data related to the level of physical activity of climacteric women using the IPAQ, we used 2 algorithms: Kohonen and k-means, and, to evaluate the validity of these clusters, 3 indexes were used: Silhouette, PBM and Dunn. The questionnaire was tested for validity (factor analysis) and precision (Cronbach's alpha). The Random Forests technique was used to assess the importance of the variables that make up the IPAQ. To classify these variables, we used 3 algorithms: Suport Vector Machine, Artificial Neural Network and Decision Tree. The results of the tests to evaluate the clusters suggested that what is recommended for IPAQ, when applied to climacteric women, is to categorize the results into two groups. The factor analysis resulted in three factors, with factor 1 being composed of variables 3 to 6; factor 2 for variables 7 and 8; and factor 3 for variables 1 and 2. Regarding the reliability estimate, the results of the standardized Cronbach's alpha test showed values between 0.63 to 0.85, being considered acceptable for the construction of the construct. In the test of importance of the variables that make up the instrument, the results showed that variables 1 and 8 presented a lesser degree of importance and by the analysis of Accuracy, Recall, Precision and area under the ROC curve, there was no variation when the results were analyzed with all IPAQ variables but variables 1 and 8. Through this analysis, we concluded that the IPAQ, short version, has adequate measurement properties for the investigated population.
Predicting in-hospital mortality from Coronavirus Disease 2019: A simple validated app for clinical use
Authors: Magro Bianca , Zuccaro Valentina , Novelli Luca , Zileri Lorenzo , Celsa Ciro , Raimondi Federico , Gori Mauro , Cammà Giulia , Battaglia Salvatore , Genova Vincenzo Giuseppe , Paris Laura , Tacelli Matteo , Mancarella Francesco Antonio , Enea Marco , Attanasio Massimo , Senni Michele , Di Marco Fabiano , Lorini Luca Ferdinando , Fagiuoli Stefano , Bruno Raffaele , Cammà Calogero , Gasbarrini Antonio
Published: January 2021

Backgrounds

Validated tools for predicting individual in-hospital mortality of COVID-19 are lacking. We aimed to develop and to validate a simple clinical prediction rule for early identification of in-hospital mortality of patients with COVID-19.

Methods and findings

We enrolled 2191 consecutive hospitalized patients with COVID-19 from three Italian dedicated units (derivation cohort: 1810 consecutive patients from Bergamo and Pavia units; validation cohort: 381 consecutive patients from Rome unit). The outcome was in-hospital mortality. Fine and Gray competing risks multivariate model (with discharge as a competing event) was used to develop a prediction rule for in-hospital mortality. Discrimination and calibration were assessed by the area under the receiver operating characteristic curve (AUC) and by Brier score in both the derivation and validation cohorts. Seven variables were independent risk factors for in-hospital mortality: age (Hazard Ratio [HR] 1.08, 95% Confidence Interval [CI] 1.07–1.09), male sex (HR 1.62, 95%CI 1.30–2.00), duration of symptoms before hospital admission <10 days (HR 1.72, 95%CI 1.39–2.12), diabetes (HR 1.21, 95%CI 1.02–1.45), coronary heart disease (HR 1.40 95% CI 1.09–1.80), chronic liver disease (HR 1.78, 95%CI 1.16–2.72), and lactate dehydrogenase levels at admission (HR 1.0003, 95%CI 1.0002–1.0005). The AUC was 0.822 (95%CI 0.722–0.922) in the derivation cohort and 0.820 (95%CI 0.724–0.920) in the validation cohort with good calibration. The prediction rule is freely available as a web-app (COVID-CALC: https://sites.google.com/community.unipa.it/covid-19riskpredictions/c19-rp).

Conclusions

A validated simple clinical prediction rule can promptly and accurately assess the risk for in-hospital mortality, improving triage and the management of patients with COVID-19.
Self-fashioning and othering: Women’s double strategies of travel writing
Authors: Boter Babs , Villaescusa Illán Irene
Published: January 2021

This essay examines early 20th century travel texts written by two European women: the Catalan journalist Aurora Bertrana (1899-1974) who lived in French Polynesia from 1926 until 1929, and her contemporary, the Dutch journalist Mary Pos (1904-1987), who travelled to the Dutch East Indies in the fall of 1938 and returned early in 1939. Our research is double-focused: on the one hand it examines issues of empire, colonisation, and orientalism, and on the other hand it explores issues of modernity and feminism. The travel texts under study offer personal registrations of self-fashioning strategies that both authors employ, which significantly question gender expectations regarding women’s social and sexual practices, their professional, familial and marital roles, and their opportunities for education. Presenting them as emancipated modern women, however, the accounts are also embedded in an orientalist and colonial discourse and seem to impose their own views of modernity and feminism on other women–despite ardent appeals to intercultural understanding.
British Influence as a Factor of Forming the Modern Identity of Hong Kong
Authors: Papashvili G.Z. , Kurnykin O.Yu. , Tazhiyeva M.N.
Published: January 2021

The article considers the process of forming the modern identity of Hong Kong and proves underlying role of the British influence in this process. It is pointed out that the process goes back to the 19th century, when well-off Chinese started to move to the British Hong Kong in trying to find more comfortable conditions for life and business and reaches its pinnacle in 1970-1980, when Hong Kong not only becomes economically developed but transforms into a factor of cultural influence in the region mainly due to the promotion of its original (civilization-state) pop-culture. It’s stated that Hongkongers use cultural and semiotic resources to emphasize specificity of their cultural code. And particularly these kinds of resources played the biggest role in this process. Authors conclude that the British influence was one of the structural factors which determined the nature and contents of Hong Kong’s identity. At the same time, they note that the process of its forming is based on evolved for centuries Chinese national tradition which contains self-preserving mechanisms which make it possible for Hongkongers to interpret external cultural drawings in a unique way.
Securitization of Memory Politics and Identity Politics as Academic and Political Tools
Authors: Fadeeva L.A.
Published: January 2021

The article discusses securitization of memory politics and identity politics as a part of academic tools and some kind of political tools. The author characterizes the process of securitization analyzing both academic and political discourse of the last decade. The securitization of the politics of memory and identity, as well as the politicization of history are reflected in academic publications and political declarations, pouring out into hot discussions, debates, wars of memory, struggle of identities. Research findings can create basis for a political turn or a new foreign policy course. Securitization puts the category of identity in the context of international security while identity politics could be used as a soft power element or foreign policy tool. There has been a turn towards defining identity politics as a concrete ideological weapon that can be used against opponents in the ideological and political struggle. This significantly changes meaning of identity politics. The author considers that in scientific analysis it is advisable to avoid extreme politization of identity.
Magyarországi „munkavállaló-barát” (employee friendly) szervezetek – Valóság vagy utópia (avagy mit tanulhatunk tőlük?) = The Hungarian employee friendly organizations: reality or Utopia (or what can we learn from them?)
Authors: Primecz Henriett , Kiss Csaba , Toarniczky Andrea , Csillag Sára , Szilas Roland , Bácsi Katalin , Milassin Anda
Published: January 2021

A szerzők feltáró kutatásukban munkavállaló-barát szervezeti megoldásokat kerestek és vizsgáltak multiparadigmikus (Primecz, 2008) megközelítéssel, kritikai és funkcionalista szemszögből. Munkavállalóbarát szervezeti gyakorlatnak tekintették azokat a szervezeti kultúrában gyökerező szervezeti kereteket és gyakorlatokat, amelyek nagymértékben támogatják a munkavállalókat a munka és magánélet egyensúlyának elérésében és megtartásában (Toarniczky et al., 2011). Eredményeik szerint a munkavállaló-barát gyakorlatokat akkor értékelik legjobban a szervezeti tagok, ha a közvetlen vezető és kollégák jól értik a támogatandó munkavállaló helyzetét és rugalmasan fordítják le a hétköznapokra a HR-rendszereket. Ezzel együtt több feszültség keletkezik a szervezetben a munkavállaló-barát gyakorlatokban, amelyekre figyelni lehetne, anélkül, hogy a kialakított gyakorlatokat felszámolnák. _____ The authors in their research investigated employee friendly practices, which they defined as frameworks and practices rooted in organisational culture that gives maximum support for employees trying to reach and keep balance between work and private life (Toarniczky et al., 2011) through multiparadigm research (Primecz, 2008). They conducted exploratory research (interviews, focus groups, document-analysis, and questionnaire) at ten Hungarian-based organizations, and they investigated employee friendly work practices through functionalist and critical lenses. Their results shows that employee friendly practices work well, when the immediate boss and colleagues understand the need of organization al member, who are supported, and HR procedures are translated flexibly. At the same time tension within the organization al subgroups always present, and this should be handled by the organization without cancelling employee friendly practices.
The Morbid Equation of Quantum Numbers
Authors: Dongfang XD
Published: January 2021

The quantum model of valence electron generation orbital penetration of alkali metal elements with unique stable structure is investigated. The electric field outside the atomic kernel is usually expressed by the Coulomb field of the point charge mode, and the composite electric field in atomic kernel can be equivalent to the electric field inside the sphere with uniform charge distribution or other electric fields without divergence point. The exact solutions of two Schrödinger equations for the bound state of the Coulomb field outside the atom and the binding state of the equivalent field inside the atom determine two different quantization energy formulas respectively. Here we show that the atomic kernel surface is the only common zero potential surface that can be selected. When the orbital penetration occurs, the law of conservation of energy requires that the two energy level formulas must have corresponding quantum numbers to make them equal. As a result, there is no solution to the quantum number equation, indicating that the two quantum states of the valence electron are incompatible. This irreconcilable contradiction shows that the quantized energy of quantum mechanics cannot absolutely satisfy the law of conservation of energy.
The quest towards understanding the molecular pathogenesis of triplet repeat disorders: Huntingtons Disease and Fragile X-Associated Tremor and Ataxia Syndrome
Authors: Amado Alana , Amado Alana
Published: January 2021

Trinucleotide repeat disorders encompass a group of neurological diseases driven by unstable repeat expansions. Huntingtons disease (HD) is characterized by chorea and brain atrophy. The normal huntingtin protein contains 6-34 CAG repeats; however, upon a threshold effect of >36 repeats, the huntingtin protein acquires toxic mechanisms that are harmful to the cell. Fragile X-Associated Tremor and Ataxia (FXTAS) is characterized by tremor, ataxia and neuronal loss. The normal
FMR1 gene contains 5-45 CGG repeats; however, upon a premutation CGG expansion of 55-200, FXTAS arises. A pathological hallmark of these disorders includes aggregate formation within the brain; suggestive of impaired protein and mRNA function. Furthermore, important molecules have been found to be sequestered into these aggregates withdrawing them from their normal roles. In this review, the ways mutant huntingtin and
FMR1mRNA aggregates induce intracellular dysfunction in HD and FXTAS is analyzed, specifically in the context of impaired neuronal processes and protein-protein interactions. Analysis revealed that huntingtin and
FMR1 mRNA are involved in the regulation of multiple cellular pathways; and whose impaired function results in a detrimental domino-effect that is destructive to the cell. The understanding of these molecular processes hopes to identify potential targets towards the treatment of HD and FXTAS
Simplified climate modelling to size economic boundaries
Authors: Anderl Thomas
Published: January 2021

The broader public demand reproducibility of scientific results particularly related to hot societal topics. The present work applies the 80:20-rule to climate change, concentrating on the essentials from the readily observable and identifying the inherent relationships in their potential simplicity. Observations on 400 Mio. years of paleoclimate are found to well constrain the compound universal climate role of CO
2. Combined with observations on the industrial-era atmospheric CO
2 and ocean heat evolvement, climate risk assessment and projections on the economic boundaries are performed. Independently in conjunction with energy budget studies, simple models are presented for the fundamental natural processes related to: (i) water vapor and CO
2 effect on temperature; (ii) transient and equilibrium climate; (iii) heating from the V/R-T (vibrational/rotational to translational) energy transfer; (iv) Earth emissivity changing with surface temperature; (v) water vapor for Earths energy balance maintenance; (vi) rainfall pattern altering with temperature; (vii) natures reaction on the anthropogenic energy consumption. In conclusion, realistic estimates point at precluding positive economic growth for the foreseeable future if temperatures are to be given a reasonable chance to become sustainably contained within sensible limits.
Of Kings and Horses: Two New Horse Skeletons from the Royal Cemetery at el-Kurru, Sudan
Authors: Näser Claudia , Mazzetti Giulia
Published: January 2021

This article presents the zooarchaeological evidence from two horse burials at the royal cemetery of el-Kurru, Sudan. The skeletons, whose survival after excavation was unknown, were recently rediscovered in storage in the Sudan National Museum. The article outlines the archaeological context of these specimens, their importance for research on equids in the ancient Nile valley and the first results of their zooarchaeological analysis.
NON-DESTRUCTIVE MAGNETIC TESTING OF THE PHYSICAL AND MECHANICAL PROPERTIES OF MISSION-CRITICAL MOUNTING COMPONENTS MADE OF 30HGSA STEEL
Authors: Sandomirski S. G.
Published: January 2021

The mounting products with mission-critical functions (bolts, studs, rods) used in aviation technology are subject to increased strength, hardness, and wear resistance requirements. They are made of specially developed medium-carbon steel 30KhGSA alloyed with chromium, manganese, and silicon. According to international classifications, the steel 30KhGSA is steel 42CrMo4-T (EN), 1.7225 (DIN, W.NR), 4140H (AISI). The balance between the strength and plastic properties of the products is achieved by the choice of the mode of their heat treatment – quenching and subsequent medium or high temperature tempering. Possible deviations in the chemical composition of the product materials and the modes of their heat treatment from the prescribed ones lead to unacceptable deviations of the properties of the products. This requires monitoring all products. The physical basis of magnetic structural analysis relies on the fact that mechanical and magnetic properties of steels are sensitive to the structural transformations occurring in them during thermal treatments. It has been proven that the coercive force Нc and the remanent magnetization Мr of many steels are related to their structure. When controlling mass batches of products, the best results in reliability and productivity are achieved by magnetization of products when they fall through a coil with the direct current and measuring the remanent magnetic flux Fd in the product. In this case, Fd in the product is not proportional to Mr, but to Hc of the product material. A characteristic feature of alloyed steels with a carbon content greater than 0.3 %, including steel 30KhGSA (steels 42CrMo4-T, 1.7225, 4140H, 37Cr4, 41Cr4, 46Cr2 and others), is a non-monotonic change in Hc with an increase in the tempering temperature Tо of products. Therefore, magnetic quality control of products from such steels requires a specific procedure. To test the tempering mode of such products, we have proposed to expose the magnetized products to a graded demagnetizing field with the strength Нp, before measuring Fd. The developed method allows us to choose the value of Hp, at which the optimum sensitivity to changes in Tо is achieved while monitoring products of specific sizes. In this report we show that such testing is based on the sensitivity of Fd in the product after its reverse magnetization in the field Hp to the remanent magnetization of the material Mr. We also article the technical means ensuring application of the developed methodology in industrial settings with a control output of up to 2 products per second. Examples of application of the method for controlling the hardness of small bolts made of steel 30HGSA, intended for use in aircraft construction, are given.
ASSESSMENT OF VIBRATION ACTIVITY OF A REDUCER AT USE OF DIFFERENT LUBRICANTS
Authors: Karpenko A. B.
Published: January 2021

The serviceability and durability of mechanisms substantially depends on a correctness of the choice of lubricants and a way of greasing. As lubricants for gears of reducers and their bearings use liquid hydrocarbon and synthetic oils and also ductile lubricants. Influence of lubricant on a vibration activity of mechanisms is considered. The criterion of quality determined the minimum power of a vibration signal here. As a measuring device the analyzer of vibration Vibro Vision-2 is used. At the beginning of article the studied object – a four-stage reducer is described. Further results of measurements of power of a vibration signal in the given frequency range for each of the considered lubricants are shown. At the same time the frequency range is divided into strips. The root-mean-square value (RMS) of vibration speed which determines vibration signal power was measured in each strip. RMS observed data in each frequency band is presented as a tables and schedules. Further on the basis of the obtained data the histogram of distribution of RMS on frequency stripes where each of the considered lubricants is presented is created. In conclusion the obtained data is analysed, conclusions are drawn on the reasons of vibration and recommendations about the choice of lubricant depending on the frequency range of a gearing of teeth are made.
HEALTHCARE 2019
Authors: Matveev V. I.
Published: January 2021

The article provides a brief description of the exhibition "Healthcare 2019", which was attended by 630 companies from 30 countries and 71 cities in Russia. It was possible to get acquainted with the modern system of health care organization, the necessary simple and complex medical equipment, numerous accessories and consumables. The exhibition presented: medical x-ray equipment of wide application (computer tomographs, mammographs, mobile devices), magnetic resonance imaging, ultrasound medical equipment, microscopes, endoscopic equipment, surgical navigation systems, as well as magnetic therapy, thermography and radiothermometry. The companies showed the best examples of modern medical equipment.
INFLUENCE OF ACOUSTIC-ELECTRONIC CHANNEL ON ACOUSTIC EMISSION HIT PARAMETERS
Authors: Sazonov A. A. , Shelobkov V. I. , Ivanov V. I.
Published: January 2021

The paper deals with the influence of acoustic emission (AE) signal propagation channel on the parameters of these signals, which are used to judge the object state. It is shown that the acoustic channel, which includes the testing object and the acoustic emission transducer, has a significant influence on the parameters of AE signals. This must be taken into account, both in the interpretation of signals and in the calibration of acoustic emission transducers. Specific examples of degradation of AE signal parameters during the passage of acoustic-electronic channels are shown.
THE CALCULATION OF BACKLASH IN THE GEARS BY USING THE MONTE CARLO METHOD
Authors: Timofeev B. P. , Dang N. T. , Tran M. H.
Published: January 2021

This paper is devoted to ensuring normal lateral clearance during the normalization of manufacturing errors of gear wheels and non-gear transmission elements. The task is complicated by the fact that GOST 1643–81 sets tolerances and maximum deviations relative to the working axles of the gears. The methods of calculating the lateral clearance of spur gears are considered. As the influencing factors on the lateral clearance, the thermal expansion of the link materials, the deviation of the interaxial distance of the wheels, the deviation of the engagement pitch, the radial run-out of the gear crowns, the error in the direction of the tooth, the parallelism and skew of the axles of the wheels are taken into account. The transmission accuracy parameters are read randomly. The results of calculation by the minimum-maximum method and the probabilistic method are compared. As a probabilistic calculation method, the Monte Carlo method is adopted. The input calculation parameters are taken equal to the maximum allowable values from GOST 1643–81, the parameters of the kinematic error of the wheels for calculation by the probabilistic method are considered distributed according to the equally probable and normal distribution laws.
OPERATING RANGE RESPONSIVENESS DEFINITION OF LUMINESCENT SMART COATING BY RESULTS OF IMPACT DAMAGES PARAMETERS ULTRASONIC MEASUREMENTS
Authors: Smotrova S. A. , Ivanov V. I. , Smotrov A. V. , Kuskova A. N. , Mantrova Yu. V.
Published: January 2021

One of the characteristic aircraft damages is impact by foreign object. In subsequent operation, the presence of impact damages to airframes made of polymer composite materials (PCM) leads to a violation of their structures and integrities. To avoid accidents it is necessary to identify and measure the parameters of such damages. The paper analyzes literature data, impact tests results and ultrasonic control of PCM samples. PCM samples represent plates. Dependences of PCM samples defect size on impact energy are revealed. It is shown that at energy of effect in a range 10…45 J damages with the linear sizes 25…70 mm are formed. The difference of the damages sizes on facing and turnaround surfaces of PCM samples is noted. The largest number of procedures in aviation is visual inspection with the naked eye or using any additional equipment. Its main disadvantage in relation to composite products is the fundamental inability to detect barely visible impact damage and internal defects that do not extend to the surface. The technology of impact damage detection using special impact -sensitive luminescent smart coatings with optical properties allows to improve the visual inspection procedure qualitatively. The result of the research is to define the permissible range of coating sensitivity. The luminescent smart coating operating range is determined: 10…20 J. Luminescent smart coating is developed for detection of barely visible impact damage on composite airframes.
DETERMINING THE RESOURCE OF THE OUTER RING OF A ROLLING BEARING BASED ON SIGNAL REGISTRATION AND SIMULATION OF THE TIME DEPENDENCE OF ACOUSTIC EMISSION PARAMETERS
Authors: Nosov V. V. , Pavlenko I. A. , Artyushchenko A. P. , Grigoriev E. V.
Published: January 2021

Traditionally, the problem of monitoring the condition of rolling bearings can be solved based on registration of control signals that occur when the bearing performs a kinematic function due to contact of surface damage which is accumulated and caused by the processes of friction, impact, heat generation, contact electrical interaction, generation of elastic vibrations from them, etc. Relative to the bearing function of bearings, the diagnostic value of such signals is quite low, since they depend on many factors that are not related to resource-determining processes and play a destabilizing role in establishing the connection between control parameters and condition. The solution of the problem must be carried out based on a systematic approach linking the control of the object with the main criterion of its performance. Since the cause of bearing failures is fatigue processes occurring in the material of their elements, the most promising methods are those based on the registration of signals associated with the restructuring of the structure and the accumulation of damage of the material, and in particular, the method of acoustic emission (AE) based on recording the phenomenon of waves of elastic radiation at loading. The development of the acoustic emission method for monitoring the state of rolling bearings is based on a multi-level model of the time dependence of AE parameters, and the control is based on the assessment of the intensity parameters of the resource-determining stage of uniform elastic fracture of representative structural elements of the material of the test object. AE informative signals are selected, and diagnostic parameters are determined at the interlevel transition from macro- to micro- and nano-level. The idea of the transitions is to select representative informative parameters and to trace the connection between them through AE strength indicators that can highlight a useful signal in conditions of high instability and heterogeneity of the accompanying processes. The experimental stup and the results of experimental studies of AE of rolling bearings with an artificially created defect on the surface of the outer ring are described, the results of control are compared with the results of the analysis of the stress-strain state around the created defect, the informative value of the concentration and kinetic index and the possibility of evaluating the resource based on it are shown.
Pengaruh Katalis Genteng Tanah Liat dalam Proses Produksi Bahan Bakar Cair dari Limbah Ban Bekas dengan Proses Pirolisis
Authors: Arahim Andry Anggoro , Widayat Widayat , Hadiyanto Hadiyanto
Published: January 2021

Penelitian ini bertujuan untuk melihat pengaruh katalis dari genteng tanah liat untuk memproduksi bahan bakar cair dari limbah ban bekas dengan proses pirolisis. Pirolisis menghasilkan produk yaitu cair (yield), arang (Char) dan gas. Alat pirolisis terdiri dari tabung reaktor, pipa stainless, pipa kaca, pipa kondensor dan kompor listrik. Katalis diletakkan pada pipa yang keluar dari reaktor sehingga katalis berperan dalam proses perubahan gas hasil pirolisis menjadi cair. Hasil XRF katalis genteng menunjukkan bahwa katalis genteng tanah liat mengandung silica alumina dimana dalam proses pirolisis silica alumina digunakan sebagai polimer, isomer dan pengkrekahan pada reaksi kimia hidrothermal. Hasil tanpa katalis menghasilkan yield lebih sedikit jika dibandingkan dengan penggunaan katalis. Yield di yeield dianalisis menggunakan Gas Chromatography-Mass spectrometry (GC-MS), hasil yield mengandung hidrokarbon dengan fraksi C5-C12 (bensin) sebesar 80,94%.
Jak rozmawiać z uczniami online? Kształtowanie wartości moralnych na e-lekcjach języka polskiego
Authors: Araszkiewicz Aleksandra
Published: January 2021

Autorka odnosi się do doświadczeń nauczania na odległość, które zostało wprowadzone w polskich szkołach w marcu 2020 roku. Zastanawia się nad tym, jak w tej nowej formie edukacji można kształtować wartości moralne oraz jak można rozmawiać z nastolatkami na trudne tematy. Przedstawia propozycję utworów literackich, które można uczynić punktem odniesienia do namysłu (i dyskusji) na zdalnych lekcjach języka polskiego w klasach VII i VIII. Teksty zostały pogrupowane w obrębie takich wartości, jak: szacunek, odpowiedzialność, samodyscyplina (rozumiana jako rozwijanie własnego potencjału i samokontrola), sprawiedliwość, a także przyjaźń i miłość. Do każdej z zaproponowanych lektur autorka podaje metody i formy pracy z uczniami. Zmiana sposobu nauczania uwypukliła, jaka jest rola szkoły w nowoczesnym świecie.