bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of neutrophil gelatinase associated lipocalin, ischemia modified albumin with uric acid in the etiopathogenesis of preeclampsia
Authors: Parasher Nitin , Kaushik Priya , Singh Naveen Kumar , Sweta  , Yadav Lalit , Bhurer Yadav Bibek , Suri Arpita
Published: October 2022

Objectives

Preeclampsia is a multisystem illness that manifests in the third trimester of pregnancy after 20 weeks of gestation and is marked by proteinuria and hypertension (PE). Changes in lifestyle, such as eating a high-calorie diet and delaying delivery, have raised the likelihood of developing PE. Eclampsia, abrupt renal failure, thromboembolic episodes leading to cardiac and brain problems, pulmonary embolism, and coagulopathy associated with HELLP syndrome are a few of the complications that might follow preeclampsia in pregnant moms. The objects of this study is to estimate and correlate the levels of NGAL (neutrophil gelatinase associated lipocalin), IMA (ischemia modified albumin) and Uric acid in prreclampsia.

Methods

40 diagnosed cases of preeclampsia and 40 healthy age and gestational age matched healthy controls were included in the study. Blood samples were collected from them and serum NGAL, IMA and Uric acid levels were estimated. Estimation of NGAL (neutrophil gelatinase associated lipocalin), IMA (ischemia modified albumin) was done by commercially available ELISA kits standard spectrophotometry methods in autoanalyzer Mind ray BS300 using commercially available kits.

Results

The parameters of NGAL and IMA were significantly increased in patients with PE (p<0.001) when compared with the healthy control subjects. γ-glutamyl transferases and OPN were found in patients with ALD (p<0.001) when compared with the control subjects. OPN showed significant positive correlations with AST (r=0.76, p<0.001), ALT (r=0.64 p<0.001), ALP (r=0.68, p<0.001), and GGT (r=0.61, p<0.001).

Conclusions

The current study focuses on the roles of NGAL and IMA, two sensitive markers of kidney injury that are particularly useful in identifying widespread endothelial dysfunction. As a result, the pattern of elevated NGAL and IMA levels can be useful for diagnosis.
Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
Authors: Martins Fabiane Ferreira , Souza-Mello Vanessa , Aguila Marcia Barbosa , Mandarim-de-Lacerda Carlos Alberto
Published: October 2022

Brown adipose tissue (BAT) remains active in adults, oxidizing fatty acids or glucose and releasing energy in the form of heat. Brown adipocytes and enhanced thermogenesis are targets for treating obesity and its comorbidities. BAT shows high synthesis activity and secretes several signaling molecules. The brown adipokines, or batokines, take action in an autocrine, paracrine, and endocrine manner. Batokines have a role in the homeostasis of the cardiovascular system, central nervous system, white adipose tissue, liver, and skeletal muscle and exert beneficial effects on BAT. The systemic function of batokines gives BAT an endocrine organ profile. Besides, the batokines Fibroblast Growth Factor-21, Vascular Endothelial Growth Factor A, Bone Morphogenetic Protein 8, Neuregulin 4, Myostatin, and Interleukin-6 emerge as targets to treat obesity and its comorbidities, deserving attention. This review outlines the role of six emerging batokines on BAT and their cross-talk with other organs, focusing on their physiological significance and diet-induced changes.
Farmers’ perspectives on the adoption of smart farming technology to support food farming in Aceh Province, Indonesia
Authors: Agussabti Agussabti , Rahmaddiansyah Rahmaddiansyah , Hamid Ahmad Humam , Zakaria Zakaria , Munawar Agus Arip , Abu Bakar Basri
Published: October 2022

The possible future challenge for food agriculture development led to the transition from conventional to modern agricultural management using smart farming technology (SFT). Some factors detaining the use of SFT for food commodities, specifically in small farmers’ communities, are global climate change, low-quality human resources of farmers, and extension workers. Small farmers generally have relatively small land, limited access to capital and farming input, and grow different kinds of commodities according to seasons. This research examined the adoption readiness in using SFT for three food commodities in Aceh Province, Indonesia, namely rice, maize, and potatoes. The sample comprises 70 farmers per commodity and 48 extension workers, obtained through the quota sampling method, culminating in 258 respondents. The readiness measurement for SFT adoption was conducted by introducing various models, images, videos, and RITX applications. The collected data were investigated and analyzed using the Mann–Whitney and Kruskal–Wallis for two or more categories. The result showed that both farmers and extension workers have a positive perception of the application of SFT. However, in terms of readiness, farmers have a relatively lower readiness level than the extension workers due to their low capacity. This means it is essential to focus on the economic and capacity building of farmers by providing them with appropriate SFT devices to overcome the high investment cost and provide the technical skill for its application to overcome this situation.
Die heile Welt als Geschenk des Nils
Authors: Wimmer Stefan Jakob
Published: October 2022

Einzigartige Umweltbedingungen in Ägypten mit der Leben ermöglichenden und fördernden Fruchtbarkeit des Niltals inmitten einer lebensfeindlichen Wüste, haben eine Wahrnehmung von der Welt bedingt, die von der Zusammenschau des Gegensätzlichen durchdrungen ist. Dieses komplementäre Denken umfasst dabei alle Bereiche der Wirklichkeit: von anthropologischen und politischen Modellen bis zu religionsgeschichtlichen Paradigmen, die auch vom Alten Israel und vom Christentum reflektiert und adaptiert wurden. Diese Sicht auf die Welt hat sich Jahrtausende lang als tragfähig erwiesen und lohnt den erneuten Blick.
Alteration in NMDAR subunits in different brain regions of chronic unpredictable mild stress (CUMS) rat model
Authors: Chen Jing , Luo Yanmin , Liang Xin , Kong Xiangru , Xiao Qian , Tang Jing , Qi Yingqiang , Tang Yong , Xiu Yun
Published: October 2022

N-Methyl-d-aspartate receptor (NMDAR) signaling pathway has been implicated in the pathogenesis and treatment of depression. However, the role of NMDAR subunits in depression is still unclear. In this study, alteration in all seven NMDAR subunits in several brain areas of rats exposed to chronic unpredictable mild stress (CUMS), an animal model of depression, was detected. Our findings demonstrated that: (1) CUMS could induce a reduction in sucrose preference, an indicator of typical depression-like behaviors; (2) CUMS significantly reduced the NMDAR subunits of GluN2B and GluN3 in the medial prefrontal cortex (mPFC), but not altered all seven NMDAR subunits in hippocampus and corpus callosum of rats; (3) subunit composition of NMDARs in corpus callosum was different from that in mPFC, PFC and hippocampus; and (4) the mRNA expressions of GluN2B, GluN3A and GluN3B in mPFC as well as mRNA expression of GluN2C in corpus callosum were correlated to sucrose preference in rats. These findings suggested that GluN2B and GluN3 in mPFC may contribute to the pathophysiology of depression.
Legal validity of Online Dispute Resolution (ODR) System in India and Indonesia
Authors: Nikam Rahul Jairam , Singh Nongthombam Bangkim
Published: October 2022

Advancement in technology brought many inevitable changes with more efficiency, making human life easier. Benefit of technology shall be incorporated for effective and efficient justice delivery in dispute resolution mechanism. New development in this area is online arbitration dispute resolutions (ODR) which have been without doubt adopted and practices by justice delivery system across the globe. But the question remains the same as whether justice delivery system is equipped to cope up in the same pace with the changes taking place in the society and technology. Are the existing laws being enough to conduct online system as an effective mechanism to settle disputes among the parties? Keeping in context the preceding query, the present research resorted tracing the laws relevant to the use of ODR mechanism in India and Indonesia, as their present legal framework of arbitration addressing dispute resolution through the ODR mechanism lack specific laws. The present research adopts a mixed method using both primary and secondary data for tracing and comparison the ODR system in India and Indonesia. It is concluded that ODR deliverance are valid and enforceable in the present legal framework of both the countries. Therefore, people must not be doubtful while using ODR mechanism to settle their disputes. It also demonstrates that an ample scope is there in the existing laws of both the countries to accommodate and enhance the overall process and deliverance of ODR mechanism through amendments and separate guidelines.
COMPLEX COACERVATION OF CHICKPEA PROTEIN ISOLATE AND PECTIN: EFFECT OF BIOPOLYMER RATIO AND pH
Authors: ADAL Eda
Published: October 2022

Complex coacervation is an up-and-coming encapsulation technique widely working in the medicinal, food, agriculture, and textile industries. This study investigated the effect of biopolymer ratio and pH on the complexation between chickpea protein isolate (CPI) and pectin (PC) through zeta potential, turbidity measurement, and visual observations. Pectin showed a negative charge profile between pH 2-9. The isoelectric point of the chickpea protein isolate was found as 4.5 (pI). Soluble complexes were formed in the system with pHs below the pI of CPI with positive charges, whereas PC had negative ones. Complex coacervates formed at pH 3.1 with a 4:1(CPI: PC) biopolymer ratio. The turbidity and visual appearance revealed that larger aggregates were formed in CPI-PC coacervates. The findings could help in the development of pH-sensitive biopolymer carriers for use in functional foods and biomaterials.
ANALYSIS OF RASFF NOTIFICATIONS: 2021 FOOD AND FOOD CONTACT MATERIAL DATA REVIEW
Authors: IRMAK Nil , YILMAZ Kübra , DENİZ ŞİRİNYILDIZ Derya , YORULMAZ Aslı
Published: October 2022

Rapid Alert System for Food and Feed (RASFF) is a system that provides rapid information exchange to ascertain food safety. The aim of the current study is to prepare a detailed report of food and food contact material notifications of the year 2021 in RASFF portal. The related data in the internet tool were extracted and analyzed for subject, notification basis, notification type, products, notifying country, risk level, distribution status and measures taken. A total of 4438 notifications were identified and the most frequent hazard was pesticides. Alert, border rejection, information notification for attention, information notification for follow-up and news notification classes contained 1455, 1433, 972, 564 and 13 notices, respectively. The most frequently notifying country was Germany, followed by Spain. The mostly notified product category was fruits and vegetables and the majority of the cases had serious risk degree.
How COVID-19 Has Redistributed Human Mobility
Authors: Xiang Biao
Published: October 2022

The pandemic has ushered in drastic new restrictions on the right to move, as governments have imposed lockdowns in more or less organized ways. In pursuit of its zero-COVID policy, China has gone farther than most in the extent and rigor of its mobility restrictions. Responsibility for enforcement has been redistributed to lower-level officials, landlords, and migrant labor agencies, while food delivery companies and others in the mobility business have thrived. These redistributions of mobility are likely to remain in place beyond the pandemic, changing relations between government and citizens.
American Exceptionalism Redux
Authors: Delton Jennifer
Published: October 2022

A medical anthropologist’s analysis of pandemic attitudes in her Midwestern hometown draws on social science to explain lack of trust in expertise. But Americans had much greater trust in science and vaccines in the mid-twentieth century.
Transfer from Land Rights to Right of Building Use of Land from Stock Capital in the Limited Liability Company
Authors: Powers Madeleine Rose , Nugraheni Prasasti Dyah
Published: October 2022

In establishing Limited Liability Company, capital stock in the form of land is usually used. This is because the land has an economic value that continues to increase and has never decreased in certain period time. In this journal, author wants to analyze legal consequences of transfer of ownership rights to land to building rights on land from status of land ownership as result of inclusion of share capital in Limited Liability Company and legal reasons for not permitting ownership of land as condition for establishing Company. In this journal, author uses juridical and normative research method, which is legal writing which is carried out by analyzing secondary legal materials or library materials to find solution to legal problem that arises and uses problem approach based on law statute approach or general legal rules regarding land ownership that currently apply and problem approaches that are based on conceptual basis. The results of writing show that legal reasons do not allow and permit Limited Liability Company to control land with property rights relationship.
Role of Damang (Tribal Chief) on Domestic Violence Cases (Study at Palangka Raya City, Indonesia)
Authors: Husein Agustina Rahayu
Published: October 2022

This study aims to introduce the community to the customs of the Dayak tribe as well as to describe the role of the traditional head damang in handling cases of domestic violence that occurred in the city of Palangka Raya. The people of Central Kalimantan carry out their lives based on rules, norms or orders in navigating life that are regulated by traditional institutions in the form of kedamangan which in this kedamangan customary institution consist of damang, sub-district customary mantir, and village customary mantir. Damang is a customary leader and head of the district level customary peace mantir density who is authorized to enforce Dayak customary law in a customary area. The problem of domestic violence is a serious case that must be handled by the damang because the damang is a person who has the position to resolve and decide on a customary case that occurs in the adat community.
Advocacy and Combating Sexual Crimes in the Perspective of Child Protection Law
Authors: Mujiarti Umi
Published: October 2022

The purpose of this research is to find the right forms of advocacy against Child Victims of Sexual Crime and Efforts to Overcome Sexual Crime in a Child Protection Perspective. The method in this research is the Participant Research Method (the Method of the Participant Observer), which is to fully involve oneself in Advocacy and Efforts to Overcome Sexual Crimes against Children. This research with through an empirical juridical approach by conducting research approaches regarding matters that are juridical (law) and with a fact of facts that occur regarding matters of an empirical nature. The results in this study are forms Advocacy and Efforts to Overcome Sexual Crime in a Child Protection Perspective, in accordance with the Law on Child Protection, namely advocacy in the form of litigation (legal assistance / through judicial channels) and non-litigation (assistance outside the court route), efforts to combat sexual crimes by means of preventive (prevention), repressive (action); persuasive (by persuading or directing the community to comply with the prevailing values â€‹â€‹and norms) this is done by means of socialization and direction, coercive is control that is harsh or firm in nature (for example the imposition of a sentence by a judge) and rehabilitative (social rehabilitation).
Indonesian Penal Reform: Concept and Direction of Thought
Authors: Allamah Gita Nuzula , Masyhar Ali
Published: October 2022

Criminal law reform is essentially an effort to review and reform (reorientation and reform) criminal law in accordance with the development of the socio-political and socio-cultural values of Indonesian society that underlie social policies, criminal policies and law enforcement policies in Indonesia. Criminal law reforms in the context of improving the penal system are still being carried out. The reform of Indonesian law is currently directed at efforts to reorient the substance of criminal law rules which are considered no longer relevant to the life of the Indonesian people because many evil acts in the optics of society are not considered evil and are prohibited in the optics of positive law. All happened because Indonesian criminal law in general is a legacy from the Dutch, which is culturally different from the culture of Indonesian society which is Eastern-style. If you place the law as a reflection of society, then the current Indonesian criminal law does not reflect this, then the reform of Indonesian criminal law currently leads to a reorientation of the substance of Indonesian criminal law according to the will of the community.
Written Quotations and Its Legal Protection: How Indonesian Law Reform on Copyrights Law?
Authors: Fuadi M. Zulvi Romzul Huda , Diniyanto Ayon
Published: October 2022

Copyright is still on its way to legalizing a lot of homework to be done. One of these jobs is to protect the economic rights of cited sources for commercial use. So far, the copyright law has not specifically regulated this matter. The law does not even protect the economic rights of citation sources quoted for commercial purposes. This study formulates the problem (1) how is the current legal protection regarding copyright for written works? and (2) how the legal protection should be regarding copyrights for excerpts of written works. The aims of this research are (1) to find out the current legal protection regarding copyright for citations of written works; and (2) formulating the legal protection that should be on copyright for excerpts of written works. The method used in this research is using normative juridical research. The conclusion in this study is to answer the formulation of the problem.
The Expression Change of Mmp-8 and Collagen Type-2 Intracell in Lung Tissue Due to Electronic Smoke Exposure
Authors: Suryadinata Rivan Virlando , Wirjatmadi Bambang , Andriani Merryana , Sumarmi Sri
Published: October 2022

The number of electronic smokers has increased annually. Exposure to an electronic cigarette will increase free radicals in the body and result in oxidative stress causing lung tissue damage. The severity degree of lung tissue damage caused by electronic smoke exposure depends on the duration of electronic cigarette smoke exposure, and will affect Matrix Metalloproteinase-8 and collagen type-2 in the cells. The study aims to understand the change degree of Matrix Metalloproteinase-8 and collagen type-2in lung tissue due to electronic cigarette smoke exposure. This study applied the experimental method with a post control group design. The male Wistar rats were used as the animal models in this research to assess cell damage through the Matrix Metalloproteinase-8 expression and collagen type-2 in the lung tissue using immunohistochemical staining. Exposure to electronic smoke cigarettes was given to each group of animal models with the difference in amount and time duration. The expression of Matrix Metalloproteinase-8 indicated a significant increase due to electronic smoke exposure (ANOVA, p=0.000). Meanwhile the expression of collagen type-2 showed a significant decrease because of electronic smoke exposure (ANOVA, p=0.000). Besides, MMP-8 and collagen type-2 manifested relationship existence and strong impact (r=0.948, p=0.000).  The negative impact of exposure to electric cigarette smoke causes increased expression of Matrix Metalloproteinase-8 and decreased expression of type-2 collagen in lung tissue.
Population Control Policy Implementation in the Framework of National Health Insurance
Authors: Wahyudi Fikri Mourly , Siswanto Hadi , Hartono Budi
Published: October 2022

The presence of National Health Insurance at the same time with the implementation of regional autonomy affects the implementation of many other policies, including population control. Different understanding and commitment of implementors resulted in mixed results, with unsuccessful trends of implementing population control policy in the frame of National Health Insurance. Cimahi as the most populous city in West Java needs to implement the policies effectively to prevent negative impact of overpopulation. An analysis needs to be conducted to assess the implementation of the policies in Cimahi. The purpose of this study was to analyze the implementation of population control policy within the framework of National Health Insurance. This research was conducted in Cimahi and used qualitative design with case study approach. Data collected through in-depth interview and questionnaires to the implementors of the policies. Data analyzed with the concept of Edwards III and Analysis Hierarchy Process. The results showed that the policies implemented facing difficulties, with National Health Insurance not necessarily encouraging population control through the use of contraceptive. It is suggested that Cimahi City Government improve policies implementation by integrating mutually supportive policies, communicating and disseminating, increasing resources, and increasing cooperation between institutions.
COPD Symptoms and Risk Factors of Respiratory Disorders in Builders
Authors: Lorensia Amelia , Suryadinata Rivan Virlando , Savitri Kadek Yuli Dwi
Published: October 2022

Decreased lung function is at risk for COPD (chronic obstructive pulmonary disease). Risk identification is a strategy to improve the quality of self-management, through the identification of risk factors and early symptoms of COPD. This study aims to determine the relationship between risk factors and early symptoms of COPD in builders related to pulmonary function disorders. The design of this study was case control in Rungkut District, Surabaya in September-December 2018. The research variables were lung function disorders, risk factors and early symptoms of COPD, with ordinal data scale and chi-square test analysis. This study involved 158 respondents consisting of 79 respondents with lung function disorders and 79 respondents with no lung function disorders. The highest total risk factor for COPD in both groups was smoking, and there was no significant difference (P = 0.75) on the early symptoms of COPD in the pulmonary dysfunction group and in the group with no lung function disorders. The highest total initial symptoms of COPD in both groups were chronic cough and sputum hypersecretion. However, there was no significant difference between the two groups (P = 1.00). There was no relationship between COPD risk factors and early symptoms of COPD in the pulmonary dysfunction group and the no lung function group.
Stakeholder Perception of Health Resources and Village-Funds Optimizing for Maternal and Child Health Program
Authors: Sriatmi Ayun , Jati Sutopo Patria , Martini Martini , Mustofa Syamsulhuda Budi , Budiyono Budiyono
Published: October 2022

The low support on cross-sectoral commitment of village stakeholders to health programs was one of factors contributed maternal and infant mortality in Tegal Regency. Although village funds have been rolled out since 2015, its implementation hadn’t been optimal due to orientation focus on infrastructure development. The study aims to analyze perceptions and attitudes of village stakeholders towards village level resources and optimizing village funds for MCH programs based on 3 groups stakeholder (Decision Maker, Provider and Clients-Representatives). It’s quantitative research, population of all village level stakeholders with 300 people as samples from 30 selected villages. Data collected with interview using questionnaire and being analyzed with frequency distribution and statistically using Kruskal-Wallis test. Most of three group stakeholders had good perception of their health resources and positive attitude towards MCH programs, but different results were seen for attitudes towards optimizing village funds. Decision Maker group and Clients-Representatives group showed tendency refusing, while Provider group tend to agree on village funds optimizing for MCH programs. Statistically, there were differences in attitudes towards optimizing village funds for MCH program between three groups. Attitude differences was mainly due to lack of understanding from external health stakeholders about health programs, especially village’s MCH program.
Incidence of Stroke and Associated Risk Factors in Bogor, Indonesia: A Nested Case-Control Study
Authors: Saefurrohim Muhamad Zakki , Azam Mahalul , Rahayu Sri Ratna , Cahyati Widya Hary
Published: October 2022

The increasing number of stroke cases and their risk factors is a crisis that needs to be addressed. This study aimed to determine the number of new stroke cases in Bogor, Indonesia, and its risk factors. We conducted a nested case-control study from the Study of Non-Communicable Disease (NCD) Risk Factors of the National Health Institute of Research and Development, Ministry of Health, Indonesia, in 2018. A deep analysis was conducted on 1.210 respondents based on the subset of baseline this data. Data was collected by interview method on permanent residents in Bogor City, Indonesia in 2018. Diagnosis of stroke was based on the anamnesis of a neurologist and a neurological examination. Independent variables include sociodemographic characteristics, metabolic syndrome, and risky behaviors. The data was analyzed with a dual logistic regression test. The incidence of stroke during 2018 amounted to 48 cases (3.9%). The main determinants of stroke in this population include diabetes mellitus and systolic blood pressure being the main factors for stroke, with each p-value, AOR, and (95% CI) being 0,000, 0.222 (0.122-0.405), 0.003, 0.291 (0.128-0.662). There was no significant difference in metabolic syndrome outcomes one year before the diagnosis of stroke and the year when the stroke was diagnosed. Special attention is needed in DM patients with high blood pressure to prevent stroke.
Implementation of Hospital Occupational Health and Safety Standards at General Hospitals in Kendari City
Authors: Damayanty Sri , Susanto Agus , Hipta Wahyu Fajriana
Published: October 2022

A hospital is a health service facility with various activities with many potential dangers for hospital human resources and patients or patient companions. Potential hazards in the hospital can be in the form of occupational diseases and infectious diseases. There are also other potential hazards that affect the situation and conditions in the hospital. The specific objective of this research is to see the implementation of the Occupational Health and Safety standards, implemented in 3 (three) General Hospitals in Kendari City, Southeast Sulawesi. This research uses qualitative research methods with an observational approach and in-depth interviews. This research took place in 3 (three) General Hospitals in Kendari City, namely: Hospital A, Hospital B, and Hospital C. The informants in this study are those related to the K3 standard policies implementation in hospitals. The results showed that there are several hospitals that have not carried out all the stages of equipped facilities and infrastructure related to risk management aspects, efforts to manage hazardous and toxic materials (B3) from occupational safety and health aspects, to prevent and control fire as well as efforts to prepare for the face. Emergency or Disaster Conditions. It shows that the K3RS standards implementation in several hospitals has not been implemented optimally. It is recommended for the hospital to continue to refer to the rules governing the K3RS implementation. It includes the lack of infrastructure and facilities. Like always, briefings for all officers before working and evaluation at the end of each working hour.
The Oral Health and Comorbid Diseases Knowledge Between Urban and Rural Community during Pandemic
Authors: Wahyuni Indah Suasani , Herawati Irma Erika , Puspitasari Irma Melyani , Mutakin Mutakin , Milanda Tiana , Levita Jutti
Published: October 2022

The restriction of social mobility and activity during the COVID-19 pandemic has been implemented to stop the deadly transmission of the SARS-CoV2 virus. People are forced to stay at home and strictly perform the COVID-19 health protocol in their daily activities. Currently, a continuous self-maintenance of the health, including oral health, is considered the best strategy worldwide. This community service activity aimed to assess the knowledge of the urban and rural adult community about oral health, comorbidity, and the quality of life (QoL) during this pandemic situation by using a pre-and post-test quasi-experimental design with an intervention of health-knowledge sharing using leaflets and videos, and a WHOQOL 2012 questionnaire to study the QoL. Paired t-test was used as statistical analysis. Total respondents were 131 (n = 76 for urban and n = 55 for rural), selected using the purposive sampling method. There was a significant difference between the results of the pre-test and post-test in both urban and rural groups (t count ranged from 1.69 to 5.98; p 0.05). Based on the WHOQOL 2012 questionnaire, both urban (90.79%) and rural (87.27%) respondents indicated a good QoL, while the remaining was scored as medium. Physical conditions/pain was the main domain that directly affects the QoL in both communities. It could be concluded that the knowledge-sharing intervention to the community gave a good impact in enhancing the knowledge of the respondents, however, a continuous program should be further carried out for better results.
Related Factors of Anxiety Level in Covid-19 Patient during Self Quarantine
Authors: Husna Putri Halimu , Ratnasari Nita Yunianti , Marni Marni
Published: October 2022

Coronavirus disease-19 was a pandemic in the world. One of the efforts to reduce the spread of Covid-19 cases was to self-quarantine. Self-quarantine impacted emotional mental disorders in the form of anxiety. This study aimed to identify factors related to the anxiety of Covid-19 patients who were undergoing self-quarantine. METHODS: This study used a descriptive research design with a cross-sectional study. The population was all confirmed COVID-19 patients who underwent self-quarantine in Wonogiri Regency as many as 70 respondents. Samples used clustered randomized sampling with 40 respondents. The instrument used a sociodemographic questionnaire, and anxiety was measured using Hamilton Rating Scale-Anxiety. Data were analyzed using multiple linear regression. RESULTS: The results showed that the mean age was 33.58 ± 11.08 years. Most participants were women 52.5%, 87.5% of the respondents had high education background, 37.5% were medical workers, 37.5% were private workers,  and 95% of the participants had received information about covid-19. The mean of the time they were self-quarantined was 8.1 ± 4.77 days. 55% of the participants had no anxiety, 15% had mild anxiety, 10% had moderate anxiety, and 20% had severe anxiety. Factors that affect the level of anxiety are age (p-value = 0.047), occupation (p-value = 0.031), education (p-value = 0.035) and length of self-quarantine (0.023). CONCLUSION: The conclusion said that age, occupation, education, and length of self-quarantine have a strong relationship and have a significant effect on anxiety. Social support is needed to reduce the anxiety of COVID-19 patients during self-quarantine.
Defining acute Essex-Lopresti injuries is problematic and variable: a systematic review
Authors: Kooistra B , van den Bekerom M , Priester-Vink S , Barco R
Published: October 2022

Purpose

The aim of this study was to systematically review clinical studies on the employed definitions of longitudinal forearm instabilities referred to as Essex-Lopresti (EL) injuries, interosseous membrane (IOM) injuries or longitudinal radioulnar dissociation.

Methods

A systematic literature search was performed in MEDLINE, Embase, CINAHL, Web of Science and Cochrane databases, adhering to PRISMA guidelines. All data on diagnosis and treatment were collected.

Results

In total, 47 clinical studies involving 266 patients were included. Thirty-nine of 47 studies did not mention an IOM lesion as part of the EL injury. The amount of preoperative positive ulnar variance varied from >1 to >12 mm. Nine studies used some form of dynamic pre-operative or intraoperative test of longitudinal radioulnar instability.

Conclusions

There is no accepted definition of EL injury in the literature. In order to prevent underdetection of acute EL injury, a radial head fracture in a patient with wrist and/or forearm pain should raise awareness of the possibility of an EL injury. In this case, comparative radiographic studies and some form of dynamic assessment of longitudinal radioulnar stability should be performed.
EGF promotes human trophoblast cell invasion by downregulating CTGF expression via PI3K/AKT signaling
Authors: Cheng Jung-Chien , Gao Yibo , Chen Jiaye , Meng Qingxue , Fang Lanlan
Published: October 2022

In brief

Although the pro-invasive role of epidermal growth factor (EGF) has been reported in human trophoblast cells, the underlying mechanism remains largely unexplored. This work reveals that EGF-induced downregulation of connective tissue growth factor (CTGF) mediates the EGF-stimulated human trophoblast cell invasion.

During the development of the placenta, trophoblast cell invasion must be carefully regulated. Although EGF has been shown to promote trophoblast cell invasion, the underlying mechanism remains largely undetermined. Our previous study using RNA-sequencing (RNA-seq) has identified that kisspeptin-1 is a downstream target of EGF in a human trophoblast cell line, HTR-8/SVneo, and mediates EGF-stimulated cell invasion. In the present study, after re-analysis of our previous RNA-seq data, we found that the CTGF was also downregulated in response to the EGF treatment. The inhibitory effects of EGF on CTGF mRNA and protein levels were confirmed in HTR-8/SVneo cells by reverse transcription quantitative real-time PCR and western blot, respectively. Treatment with EGF activated both PI3K/AKT and ERK1/2 signaling pathways. Using pharmacological inhibitors, our results showed that EGFR-mediated activation of PI3K/AKT signaling was required for the EGF-downregulated CTGF mRNA and protein levels. Matrigel-coated transwell invasion assays demonstrated that EGF treatment stimulated cell invasion. In addition, the invasiveness of HTR-8/SVneo cells was suppressed by treatment with recombinant human CTGF. By contrast, siRNA-mediated knockdown of CTGF increased cell invasion. Notably, the EGF-promoted HTR-8/SVneo cell invasion was attenuated by co-treatment with CTGF. This study provides important insights into the molecular mechanisms mediating EGF-stimulated human trophoblast cell invasion and increases the understanding of the biological functions of CTGF in the human placenta.
América Latina entre el macondismo y el moralismo
Authors: Teles da Silveira Ronie Alexsandro
Published: October 2022

Muchas de las interpretaciones acerca de las relaciones de América Latina (AL) con los procesos de modernización adoptan el macondismo. Esta perspectiva afirma que AL es refrataria a la modernidad en función de su especificidad. Por lo general, los críticos al macondismo adoptan una perspectiva moralista que ratifica que AL no presenta ningún tipo de obstáculo a la modernidad. Así, el fracaso en su implantación en AL se refiere al modo cómo las acciones y políticas se realizan. De parte del macondismo, se afirma la existencia de una materia contraria a transformaciones modernizadoras. De parte del moralismo, se afirma la existencia de un medio transparente y receptivo. En el artículo, sugiero adoptar un ponto de vista intermedio dentro de este espectro que se presenta como un cuadro tensionado. Las fuerzas relevantes dentro de este se refieren a las limitaciones culturales, por una parte, y a la fuerza disciplinadora de los procesos de modernización, por otra. Este punto de vista parece más propicio a la elaboración de un discurso pertinente en cuanto a AL.
Polytrauma: Definition of the Problem and Management Strategy (Review)
Authors: Prokazyuk A. A. , Zhanaspaev M. A. , Aubakirova S. K. , Musabekov A. S. , Tlemisov A. S.
Published: October 2022

Polytrauma is a highly relevant problem from both scientific and clinical perspectives due to its high mortality rate (>20% in young and middle-aged individuals and >45% in the elderly). The lack of consensus in the definition of polytrauma complicates data collection and comparison of available datasets. In addition, selection of the most appropriate management strategy determining the quality of medical care and magnitude of invested resources can be challenging.

Aim of the review. To revisit the current definition of polytrauma and define the perspective directions for the diagnosis and management of patients with polytrauma.

Material and methods. Based on the data of 93 selected publications, we studied the mortality trends in the trauma and main causes of lethal outcomes, analyzed the polytrauma severity scales and determined their potential flaws, examined the guidelines for choosing the orthosurgical strategy according to the severity of the patient’s condition.

Results. The pattern of mortality trends in trauma directly depends on the adequacy of severity assessment and the quality of medical care. The Berlin definition of polytrauma in combination with a mCGS/PTGS scale most accurately classifies polytrauma into four severity groups. For the «stable» patients, the use of primary definitive osteosynthesis with internal fixation (early total care, or ETC) is the gold standard of treatment. For the «borderline» and «unstable» groups, no definitive unified strategy has been adopted. Meanwhile, in «critical» patients, priority is given to general stabilization followed by delayed major surgery (damage control orthopaedics, or DCO), which increases survival.

Conclusion. The use of artificial intelligence and machine learning, which have been employed for more specific goals (predicting mortality and several common complications), seems reasonable for planning the management strategy in the «controversial» groups. The use of a clinical decision support system based on a unified patient registry could improve the quality of care for polytrauma, even by less experienced physicians.
Applying digital technologies in the inclusive education at universities
Authors: Muller Olga
Published: October 2022

The article analyzes theoretical and practical aspects of the use of digital technologies in a university environment, notes the main problems and opportunities for integrating digital technologies into inclusive education. On the basis of the studied material, the author compiled the visual structure of the digital inclusive educational environment, demonstrating the multidimensionality and complexity of the digitalization process of inclusive education. A high level of preparation of students with special educational needs in the digital environment is an urgent task in the educational system, which can be ensured through the implementation of certain pedagogical conditions. The purpose of the article is to confirm the effectiveness of the implementation of pedagogical conditions for the formation of information competence of students with special educational needs by means of e-learning. As the designated pedagogical conditions, the following are described: the development of electronic information and educational environment and the development of interactive educational content by means of information technology. The scientific novelty of the research lies in the fact that pedagogical conditions have been developed and substantiated, contributing to the effective formation of information competence of students with special educational needs by means of e-learning. The theoretical significance of the work is presented by the results of the selection and systematization of the results of scientific research on the problem under study, which provides an objective and comprehensive view when assessing the prospects for the use of digital technologies in the context of inclusive education at a university. The practical significance of the work is presented by the developed pedagogical conditions that can be applied in the practice of teaching universities in order to improve the quality of training for students with special educational needs. Research methods: generalization, analysis and synthesis of information, comparison.
Incidentally Diagnosed Extraluminal Leiomyosarcoma of Infrarenal Inferior Vena Cava: A Case Report and Literature Review from a Radiologist’s Perspective
Authors: A Ebinesh , Ashta Aanchal , Satyam Satyam , Shanker Pradhan Gaurav , Sharma Rohin , Das Prince
Published: October 2022

Background: Vascular leiomyosarcoma is a rare but most common vascular tumor of the inferior vena cava.Case presentation: We present the case of an incidentally diagnosed extraluminal leiomyosarcoma of the inferior vena cava in a 62 year old patient who presented with abdominal pain following blunt trauma. Ultrasonography showed a lobulated hypoechoic lesion in the upper abdomen. Computed tomography (CT) and magnetic resonance imaging (MRI) showed a circumscribed lobulated near homogeneously enhancing retroperitoneal lesion in anterior relation to the infrarenal inferior vena cava, right paramedian in location with imperceptible vena caval lumen at the site of maximum contact. In positron emission tomography (PET) CT the lesion showed mild fluorodeoxyglucose (FDG) uptake with no distant metastases. CT guided biopsy with immunohistochemical analysis showed leiomyosarcoma. Patient underwent surgical resection with inferior vena cava reconstruction.Conclusions: Leiomyosarcoma of the inferior vena cava is a rare tumor of vascular origin. Imaging plays an imperative role in the diagnosis and preoperative evaluation. This article also provides a comprehensive literature review of the radiological features of inferior vena caval leiomyosarcoma that would aid in optimal preoperative characterization and evaluation.
Importance of Sustainability Indicators in Construction SSCM
Authors: Cataldo Ieva
Published: October 2022

For ongoing review in the strategic planning of the construction industry, numerous complex categories such as ecological, social, and economic are necessary. The present research and analysis look at sustainable supply chain management (SSCM) in the construction industry from a holistic viewpoint, focusing on the construction company's long-term sustainable decision-making tools rather than only SCM for building projects. This article specifies a number of sustainability measures for assessing supplier networks of construction companies. By analyzing their use in prior literature and agreeing to the explanation, those indicators were grouped and assigned to the categories which better reflect the SSCM principle of their application in the construction sphere. For sustainable policymakers and construction business managers, the use of indicators can aid in the development of policies for the construction sector.
HER2 onkogeno amplifikacijos ir raiškos variacijos šaltinių nustatymas
Authors:   , Radžiuvienė Gedmantė
Published: October 2022

Assessment of sources of variation in HER2 oncogene amplification and expression
Gender peculiarities of visual perception and information processing in wrestlers
Authors:   National Universitiy of Ukraine on Physical Education and Sport, Korobeynikova L. , Berejna A. ,   National Universitiy of Ukraine on Physical Education and Sport, Korobeynikov G. ,   National Universitiy of Ukraine on Physical Education and Sport, Danko T. ,   National Academy of Security Service of Ukraine, Kostuchenko V. ,   National Universitiy of Ukraine on Physical Education and Sport
Published: October 2022

. Purpose: to study gender peculiarities of visual perception and information processing of female wrestlers. Material and methods. The research involved 23 female and 22 male wrestlers, members of the national teams of Ukraine. We studied the perception and decision-making in testing conditions using the hardware and software complex «Multispychometer-05». The perception of visual information was studied by the perceptual speed test. The athlete was asked to find the missing element of geometric shapes among the proposed on the display screen. The task was to quickly and accurately recognize the missing element. The following indicators were determined: speed, performance, accuracy and efficiency of visual perception. Decision making was studied by a choice test among three stimuli of different colors. The stimuli appeared randomly, the task of the athlete was to respond quickly and accurately to the corresponding stimulus with the right or left hand. The speed of sensory response was studied by the test of determining the latent time of a simple visual-motor reaction. The sportsman was offered to react to a random stimulus as quickly as possible. The latency and stability of the reaction were determined. Results: the study of gender peculiarities of visual perception and information processing in wrestlers was conducted. For sports wrestling perception and processing of information is an important property that provides adequate decision-making in the fight with the active action of the opponent. The best indicator in the study of decision-making time, in terms of choosing stimuli among different external stimuli, was found in men. They make decisions more quickly in conditions of time limit than women. At the same time, women have a faster level of perception of visual information with simultaneous psycho-emotional stress. Men have a faster nature of information processing and decision-making on external visual stimuli. It is advisable to use the results of the study for the construction of training load of women in wrestling. Conclusions. The results of the study showed that the faster nature of visual perception in women who specialize in wrestling than in men wrestlers. The presence of faster decision-making in men wrestlers compared to women in the choice of an external stimulus was revealed. The slowing down of the time of visual-motor reaction in women against the background of the growth of psycho-emotional tension is established. Keywords: freestyle wrestling, elite sportsmen, visual-motor reaction, gender peculiarities.