bluuebunny/crossref_metadata_2025 huggingface dataset:
ПЕРЕОСМИСЛЮЮЧИ ГЕНОЦИД: КОЛИ СУСІДИ ПОЧИНАЮТЬ НЕНАВИДІТИ
Authors: Gerasimov Ilya
Published: January 2022

Ілля Герасимов вважає, що емпіричний матеріал, представлений у книжці Омера Бартова («Анатомія геноциду: життя і смерть міста, що називалось Бучач», Нью-Йорк, 2018), суперечить моделі, запропонованій автором. У галицькому містечку Бучач, де євреї, українці та поляки жили разом упродовж століть, місцеві жителі-християни взяли активну участь у Голокості, а потім і в українсько-польських етнічних чистках. Пояснення Бартовим масового знищення сусідів у роки Другої світової війни засноване на телеологічному баченні поступової ескалації давніх міжетнічних конфліктів до рівня відкритого насильства. Герасимов показує, що книга залишає без відповіді два ключові питання: як пояснити максимальну інтенсивність Голокосту в регіоні, який не мав передісторії насильства по відношенню до євреїв (якщо саме «сусіди» становили основну масу переслідувачів євреїв, як стверджує Бартов)? І чому «сусіди» настільки одностайно виступили проти місцевих євреїв (якщо, як показує книжка, Голокост був організований і координувався нацистами)? Спираючись на насичений опис Бартовом Голокосту в Бучачі, Герасимов пропонує власні відповіді на ці запитання. Він розглядає  участь у геноциді давніх членів однієї соціальної мережі («сусідів») як типовий і навіть основоположний фактор, а не як скандальне відхилення.

Рушійною силою геноциду в цій моделі виявляється не вкорінена ненависть потужного націоналістичного руху до Іншого, а бажання приєднатися до спільноти «своїх», прагнення будь-якою ціною довести свою причетність до національного проєкту, що розсипається, у ситуації загрози національному суверенітету. В умовах війни і відсутності демократичних політичних інститутів через іноземну окупацію або диктаторський режим, коли обіцяна національна єдність підірвана громадянською війною і відсутністю самої спільної мови, здатної сформулювати і поширити критерії приналежності до єдиної нації, – це прагнення довести свою причетність через убивство «чужинця» в межах досяжності, тобто сусіда. Не давня традиція ксенофобської ворожнечі веде до геноциду, а нещодавнє і стрімко розвинене прагнення приєднатися до легітимної національної спільноти. Цим пояснюється центральна роль «сусідів» у здійсненні геноциду як спроби проведення нових кордонів політичного співтовариства «негативно» – через стигматизацію колишніх членів старого політичного простору, яких найпростіше оголосити «чужинцями» або «ворогами народу».
Business Process Analysis and Modeling Using the Business Process Improvement Framework at the Internal Quality Assurance STMIK STIKOM Indonesia
Authors: Putra Desak Made Dwi Utami , Welda Welda
Published: January 2022

STMIK STIKOM Indonesia is a college that organizes two study programs namely Informatics Engineering and Computer Systems. STIKI Indonesia has set SPMI in accordance with the PPEPP cycle. To ensure that SPMI can run as stipulated, the monitoring process is carried out with an Internal Quality Audit (AMI) facilitated by the STIKI Indonesia Internal Quality Assurance Institute (LPMI). Repeated business processes cause delays in obtaining the results of AMI's recapitulation, even though the results of the recapitulation are urgently needed as a report in the Senate Meeting to be evaluated as an effort to improve quality management at STMIK STIKOM Indonesia.

Therefore the business process model that runs on the implementation of the Internal Quality Audit of STMIK STIKOM Indonesia will further be identified the existing problems and be analyzed and corrected. Business Process Improvement (BPI) is an approach or method that the writer will use to improve existing business processes at the AMI stage. BPI aims to improve business processes and ensure that issues in an organization's business processes are handled properly. Business process modeling that will be used is Business Process Model and Notation (BPMN) which is a tool to describe or model business process diagrams based on flowchart techniques, arranged to create graphical models of business operations where there are activities and flow controls that define work order
Group Decision Support System Penentuan Dana Pengembangan Pariwisata dengan Model AHP, TOPSIS dan Copland Score
Authors: B Muslimin , Mauko Arfan , Prakoso Paholo Iman , Latipah Asslia Johar
Published: January 2022

Bali is promoting the development of tourist villages and the development of many tourist villages in the area. The development of tourism villages can generate large regional income or income derived from the tourism sector. The problem is that not all tourist villages develop and generate revenue for the government, even many tourist villages are quiet from tourist visits. The selection of the best tourism village aims to find out what supporting factors can increase tourist visits and provide assistance to the tourist village. The purpose of the aid providers is to improve the quality of tourism in the area. The model used in the selection of tourist villages is the AHP and BORDA models. Both models are able to rank tourist villages from several criteria owned by tourist villages. The decision holder in this system is the Tourism Office of Tabanan Regency and the Province of Bali..
Sistem Informasi Inventori Pada CV.Tri Manunggal Berbasis Website
Authors: Wirayanti Ni Putu Eka , Sugiartawan Putu , Suryawan I Wayan Dharma
Published: January 2022

SMKN 1 Ende has a library as one of the facilities provided by the school to support student learning activities. The existence of a library is very important in increasing knowledge for students in schools. However, based on the results of an interview conducted with one of the librarians of SMKN 1 Ende, currently, school library data management is still using manual methods such as recording visitor member data, book data, borrowing data, and returning books in the ledger. As a result, it is inefficient and has a very big risk of mistakenly recording data on borrowing and returning books and other problems that often occur, namely when searching for data on borrowing and returning books where librarians have to reopen existing files so that it takes time. long enough. To overcome the existing problems, it is necessary to make a school library information system that will be tailored to the needs of the library. Based on the description of the problems in the library of SMKN 1 Ende, the theme that will be discussed by the researcher is "Library Information System at SMKN 1 Ende is Website Based". With this system, it can help the data management process by library officers in carrying out their duties such as collecting data on library visitor members, data collection of books, data collection of borrowing transactions, and returning books so that officers complete their duties quickly.
Sistem Informasi Administrasi Pembayaran SPP Pada SD PGRI Kota Denpasar
Authors: Cintya Dewi Ni Putu Senantri , Sugiartawan Putu
Published: January 2022

Abstract. The development of information technology is currently running rapidly to reach all fields, one of which is in the field of education. In educational institutions, it requires good management of data management to meet student needs. The administrative payment system in the field of education is very important to record student administration payment payments at the school. Accuracy and accuracy in the payment system are the main factors in obtaining effective and efficient results. With the use of these computers, will make it easier to process data and is very influential in work effectiveness. So the existence of information technology is a means to facilitate the community in managing data and presenting information in an educational institution. To solve this problem, it is necessary to have the right solution in the form of an administrative information system at SD PGRI Denpasar City. The use of this information system will have a positive impact in carrying out administration and make it easier for 2 staff employees to enter the names of students, then be able to record anyone who has not or is late in paying the tuition fee. Based on the description, the title of the research to be made is the Design of Administrative Information Systems at SD PGRI Denpasar City Based on a Website.
SPK Sistem Pendukung Keputusan Promosi Kenaikan Jabatan dengan Fuzzy AHP di STMIK STIKOM Indonesia
Authors: Sugiartawan Putu , Suprihanto Didit
Published: January 2022

Employees who are placed according to their knowledge, skills, and abilities tend to have high motivation, so the resulting performance will also increase. To ensure the right person or employee in the right position too, employee selection has always been a very important part of the company organization, especially in high schools. The decision-making process for promotion of promotion can be completed with a decision support system used by managers as a support for information in solving problems to fill positions, where the performance function can calculate the consideration of each competency possessed by each HR. DSS can provide alternative solutions when a person or group of people is difficult to make the right and appropriate decision. DSS is not to replace the function of decision-makers in making decisions, but only as a tool for decision-makers in carrying out their duties. THE fuzzy AHP method is able to determine the weight with the comparison value of each criterion, and this model Fuzzy-AHP method can cover the limitations of the AHP method, namely imprecision in overcoming Multi-criteria decision making which has subjective criteria. With this method approach, the ranking results of the determination of the position are obtained in accordance with the preferences of the decision-maker
Rancang Bangun Sistem Informasi Geografis Pelanggan Unit Jasa Pengelolaan Sampah pada BUMDesa Catu Krewo Sedana
Authors: Widiartha Komang , Sandika I Kadek Budi , Kumala Dewi Desak Putu Diah
Published: January 2022

Badan Usaha Milik Desa (BUMDesa) Catu Kwero Sedana is BUMDesa located in Pecatu village, South Kuta District, Badung-Bali Regency. The waste handling mechanism carried out by the waste management service unit at the BUMDesa Catu Kwero Sedana is the collection of garbage to residents' houses or businesses in the village of Pecatu. BUMDesa focuses on the quality of services provided to its customers. Until now there are still complaints from customers, especially new customers and prospective customers, related to the start of service and / or registration as new customers. The problem that often occurs is the difficulty of finding the location of garbage collection at the customer's site. If the customer registers himself through a contribution collector who is collecting customer bills, the employee in charge of transporting waste is sometimes constrained to find the customer's location. In addition, related to the amount of tariffs that will be charged to customers. Employees of garbage transport who do not know the size of the contribution rates of customers will find it difficult to provide the range of tariffs that will be charged to customers according to the rules stated in the regulations of Pecatu village. To overcome these problems, it is necessary to have a system that can provide information to employees of garbage transport regarding the position / location of garbage collection of each customer, the amount of tariff in accordance with applicable regulations, and recapitulation of payment of customer contributions. This information system can be developed based on websites with a geographic information system (GIS) model by utilizing the Application Programming Interface (API) maps owned by Google. The application of GIS to waste management has been extensively investigated and shows positive results
Android-based Geographic Information System for Worship Places in Fakfak Regency
Authors: Arridha Riyadh , Magfirah Titing , Hayunada Carlina Dewi , Astuti Diah
Published: January 2022

The rapid development of technology greatly affects people's lives today, one of which in Fakfak City has all been entered by the development of information technology. Fakfak is one of the regencies on the Papua island, the people of Fakfak Regency highly uphold religious values ​​and it is proven by the motto "Satu Tungku Tiga Batu". In Fakfak Regency, one of the the problems faced by some people is the search of worship places that must be done manually, by asking people around, or by looking at a map. In addition, some places of worship have historical values ​​that need to be known by many people. For example, the oldest mosque in Papua and West Papua is in Fakfak Regency. Regarding to this problem, an information system was created that can display information about places of worship in Fakfak. The method used in this research is a waterfall process model. This application is tested using black box methods and questionnaires. The result reveals that an Android-based application of the Geographic Information System for Places of Worship in Fakfak Regency can help to make it easier for tourists and the Fakfak community to find and obtain information related to places of worship in Fakfak. The results of the black box test state that the functions of the application are running well. The questionnaire test gave results from questions filled out by 20 respondents who stated that the application of the Geographic Information System for Places of Worship was suitable to use by the Fakfak community in obtaining information about places of worship and information on religious history and making it easier for users to find the location of the worship places they wanted to visit.
O protagonismo estudantil e os desafios da sociedade contemporânea: um diálogo sobre projeto de vida
Authors: Rocha Sabrina Crisóstomo , Brito Renato de Oliveira , Cerce Livia Maria Rassi
Published: January 2022

Este artigo apresenta os resultados de uma pesquisa que visa compreender se o desenvolvimento de um projeto de vida individual pode contribuir para o protagonismo estudantil de jovens e adolescentes do Ensino Médio. O estudo considera aspectos como autonomia, protagonismo, engajamento, responsabilidade, dos jovens frente aos desafios da sociedade contemporânea. Este estudo foi estruturado tendo por base as respostas obtidas por meio de um questionário aplicado a 21 estudantes do Ensino Médio. Essa investigação assume caráter qualitativo pautando-se nos procedimentos da Análise de Conteúdo. Todavia, as informações coletadas também foram interpretadas de forma quantitativa. Observou-se que estudantes do Ensino Médio que refletem sobre seu projeto de vida apresentam características desenvolvidas positivamente quanto ao engajamento, dedicação, motivação, postura frente ao cotidiano e formação da identidade. Não existe um momento exato para que o indivíduo tome direção na vida, mas um atraso na escolha dele pode acarretar desistência na procura de caminhos positivos, ausência de metas, descomprometimento com a carreira profissional e familiar.
Tradeoffs in life history investment of eelgrass Zostera marina across estuarine intertidal conditions
Authors: Ruesink JL , Briones Ortiz BA , Mawson CH , Boardman FC
Published: January 2022

Plant ecological strategies are associated with tradeoffs between investment in each module (e.g. leaf, stem) and the longevity or rate of production of these modules, while clonal species can exhibit additional tradeoffs between asexual and sexual reproduction. To evaluate intraspecific life history patterns, we applied multivariate analyses to a suite of 7 distinct traits plus density in a clonal marine angiosperm (eelgrassZostera marina) across sites and seasons. We expected life history tradeoffs for ecotypes at different sites, but positively correlated investment seasonally due to variation in photoperiod at 46°N. Relative growth rate (RGR), an indicator of suitable growing conditions, varied seasonally by 3-fold and strongly tracked photoperiod, with small variation among sites. Consistent with tradeoffs across ecotypes, shoot size (length, mass), module production (leaf and shoot emergence rates), and flowering tended to load in opposite ways on the first 2 principal components (62% of total trait variation). Annual life histories were separated from perennial life histories in both space (higher tidal elevations) and time (2 mo lag in flowering). In perennial populations, flowering peaked seasonally with daylength, but size continued to increase after the summer solstice, and asexual branching occurred in early spring and late summer, so investment in most life history traits did not align with RGR. Seasonal variation in shoot density was pronounced for small ecotypes, but for larger ecotypes, variation occurred through change in shoot size. Because the functional traits of foundation species help shape their role, documented covariation in these traits addresses a gap between environmental conditions and community response that is mediated by biogenic structure.
Fertility and Pregnancy Outcomes after High-Intensity Focused Ultrasound Ablation for
Uterine Fibroids and Adenomyosis: A Review
Authors: Thomas Li Kwok To , Wong WS Felix
Published: January 2022

High-intensity focused ultrasound (HIFU) ablation, also known as focused ultrasound surgery, is the latest advancement in treating uterine fibroids and adenomyosis. Limited evidence, in terms of case series only, suggest that ultrasound-guided focused ultrasound/magnetic resonance-guided focused ultrasound treatment for fibroids and adenomyosis could be a safe alternative to myomectomy or uterine artery embolisation for females who wish to have babies. It also appears that this non-invasive HIFU treatment can shorten the treatment to pregnancy interval after HIFU ablation. Further studies are needed to confirm such findings.
The Damage of a Concrete Pavement in an Alpine Cold Region
Authors: Antonietti S. , Paglia C.
Published: January 2022

Concrete pavements still represent a wide range of existing infrastructure. In particular, for external parking lots. The concrete pavement in the present study was placed directly on a natural ground without steel rebar or nets, without separation layer against water upward movement and with no superficial abrasion coating. The structure was exposed to an alpine clima. The microstructure and several properties of the pavement were characterized, such as density, compression strength, porosity, and water permeability. After six years, the first damage appeared and the surface layer was restored by applying a 10 mm thick mortar. Cracks were formed due to the plastic shrinkage and hygrometric inadequate post-treatment, as well as differential ground subsidence. This latter was promoted by the too high presence of fine aggregate components, which induced a compaction problem. In addition, disgregation in an advanced stage was observed. Especially along the contraction junctions, because of a too early fresh mortar cutting. Freeze/thaw cycles in the presence of deicing salts, as well as vehicles loads, also increased the deterioration. Mortar detachment from the underground concrete was due to the insufficient surface preparation, lack of adhesion and no mechanical treatment, shrinkage tension, low direct tension of the mortar and general concrete low quality. Mortar spalling was also caused by the freeze/thaw cycles in the presence of deicing salts, in particular along junctions, that were cut only on a superficial level within the mortar layer and not in depth.
Success story of RCC for Heavy Loaded Pavement at Port of Montreal’s Container Terminals
Authors: D'Amours Louis
Published: January 2022

At the port of Montreal, port pavements, particularly those of container terminals, are literally bombed with various types of loadings, such as gantry cranes, forklifts or front-end loaders, non‑standard single-axle trucks and conventional trucks. The typical features of this transhipment equipment are such that it can generate significant loads and stresses in pavement structures. Indeed, wheel loads for some gantry cranes can even reach 63.7 T per wheel, which is definitely higher than the usual conventional truck load, usually a maximum of 5 tons per dual wheels. This communication will first set out the significance of such equipment and its influence on pavements, and how container terminals design methods have evolved over the past decades. Subsequently, the sustainable pavement concept, which has been in use these past years, will be presented, as well as how the design methodology has evolved through the design development. These composite pavements, which consist of RCC slabs overlaid with bituminous concrete, were developed from past experience with RCC slabs, in order to reduce maintenance requirements for transhipment area operators. The communication will also show how the methods and specifications used to construct these pavements have evolved over the past years.
An Innovative Method to Minimize the Joint Sealant Requirement in BCOA Pavements
Authors: Bulusu Venkata Joga Rao , Reddy Kusam Sudhakar , Reddy Muppireddy Amarnatha
Published: January 2022

The small paneled bonded concrete overlay on asphalt (BCOA) pavement is considered to be a very durable and maintenance free rehabilitation technique. These pavements have lower thickness requirement of cement concrete layer. However, the number of joints is high as the panel size is small and hence there is a huge requirement of joint sealant. In this work, an attempt was made to minimize the joint sealant requirement by changing the joint sawing pattern. Test section was constructed for the study and square panels of 1 m, 1.5 m size are adopted. The joint sawing was divided into two stages. In the first stage the panels were sawn into 3 m X 3 m size and after one day they are further sawed into 1 m X 1m or 1.5 m X 1.5 m sizes. It is often observed that this pattern of joint sawing results in the formation of full depth joints at a spacing of 3 m. Even in the full depth joints at 3 m interval, every third joint has a crack width of nearly 0.6 mm and other two joints have a crack width less than 0.3 mm. So, if these full depth joints only are sealed then the cost of sealant will be less and purpose of sealant will be fully served. This will save the sealant cost by 85% for 1 m panels and by 70% for 1.5 m panels. The crack width measurements and the frequency of full depth cracks are discussed.
Liquorelvezető sönt és hasi sebészet
Authors: Vertse Gergely , Takács Tamás , Szeleczky Márton , Lestár Béla , Imreh Domonkos
Published: January 2022

A szerzők három, sikerrel operált beteg esetét ismertetik, akiknél megelőzően lum­bo/ventriculoperitonealis sönt beültetése történt hydrocephalus miatt. Egy lapa­roszkópos epeműtét, egy nyílt cholecystectomia, illetve egy jobb oldali hemicolectomia esetét mutatják be, amelyeket szövődmény nélkül végeztek el. A liquorelvezető sönt megléte nem jelent kontraindikációt hasi sebészeti esetekben.
A modern inzulinkezelés inzulinpumpával, vagy inzulinpumpával és szenzorral
Authors: Gerő László
Published: January 2022

Száz évvel ezelőtt fedezték fel az inzulint. Ebből az alkalomból készült az összefog­lalás a pumpa, illetve pumpa és szenzor alkalmazásával szerzett tapasztalatokról, kiemelve a Magyarországon elérhető új alkalmazásokat. 2020. január 1-jétől ha­zánk­ban az 1-es típusú cukorbetegek 18, de továbbtanulás esetén 24 éves korukig 98%-os támogatással juthatnak hozzá az eszközökhöz. Az idősebb 1-es típusú betegek 80%-os anyagi támogatással kaphatják meg a pumpát, illetve a szenzort. Egy hazai cég által forgalmazott glükózszenzor a kö­zeljövőben szintén elérhető lesz. Kí­vá­natos lenne, hogy a labilis anyagcseréjű 1-es tí­pusú cukorbetegeknek minél nagyobb há­nyada használja az inzulinpumpát és a szenzort, mivel a kezeléssel stabilabb az anyagcsere, kisebbek a vércukorszint ingadozások és alacsonyabb lesz a glükózvariabilitás. Mindez a szövődmények kialakulásának csökkenéséhez vezethet.
Mobile Applications to Secure Tenure in Rural Tanzania
Authors: Matejcek Astrid , Verne Julia
Published: January 2022

In light of climate change, projected population growth, increasing conflicts over land and the question of food security, the Tanzanian government takes the respective visions of environmental futures as a cause and justification for particular measures in the here and now. One such modality through which agricultural futures in the Kilombero Valley are currently made present and decided upon is the use of the Mobile Application to Secure Tenure (MAST). Through the use of this application, on the one hand, a more capital-friendly land legislation should be developed. On the other hand, by issuing Certificates of Customary Rights of Occupancy (CCRO), which are supposed to offer a certain security to current land users, expected conflicts are sought to be reduced and prevented. Thus, by examining the use of MAST and the particular ways in which it renders possible futures actionable, we contribute to ongoing research that aims to illustrate how “humans [...] do not own and shape ‘their’ future alone” (Granjou et al. 2017: 8). While such technologies are generally developed and employed to increase certainty, following the implementation and effects of MAST, in particular, we will show how the specific materiality of this mobile application not only allows to secure tenure, but at the same time creates new insecurities that contribute to the complex emergence of environmental futures in this part of rural Tanzania.
Images of the Future
Authors: Schick Johannes
Published: January 2022

This article analyzes the conceptions of anticipation and invention in the philosophies of Henri Bergson and Gilbert Simondon. In doing so, I analyze the questions how futures are anticipated and what role technologies play in the anticipation and invention of the future. Technologies are increasingly used to predict, prescribe and control behavior. These technologies are based upon the ontological belief that reality is computable and predictable. With Bergson and Simondon, I aim to show that this ontology does not take the temporal structure and the anticipatory faculty of living beings into account. Anticipation is an essential activity of a living being in its milieu. In order to survive, living beings structure their milieu to make their future actions reliable. Images are central to this process. They are constantly evoked by and with practices. They are transformed and used to anticipate and imagine the future. Yet, these images are affectively charged and can be an expression of what Bergson calls “myth-making function” (fonction fabulatrice). While Bergson describes this function as a positive force, one can ask whether this force turns against itself in face of our contemporary climate crisis, digital technologies and the crisis of open democracies. An alternative is to understand and to construct technical objects as essentially open in analogy to the living being. This implies a conception of the human not as a fixed conception, but as an “open adventure” (Simondon 2016: 121)that constantly re-invents itself in relation with nature and technology.
Police, clans and cash in Somalia
Authors: Hills Alice
Published: January 2022

This article explores the ways in which emergent police forces in conflict-affected Southern societies are shaped by cultural practices operating through social phenomena.  It uses the record of the prototypical police forces found in the Somali cities of Kismayo and Baidoa, 2014-2017, to explore the ways in which culture, power relations and local realities — in this case, clan-based calculations, Somali and international politics, and physical insecurity — influence police development. It draws on the cities' experience of a donor-funded 'basic policing' programme to identify the motivating forces shaping police evolution in a society familiar with many aspects of conventional policing operations and vocabulary but positioned at the opposite end of the technical and institutional spectrum to those shaping police studies' canonical literature.
Future Fears
Authors: Garsten Christina , Sörbom Adrienne
Published: January 2022

This paper is based on ethnographic work in organization that form part of what we term the Future Industry - such as think tanks, consultancies and governmental bodies - involved in the charting, description and analysis of geopolitical future scenarios. That is to say, an industry explicitly aiming for organizing the future. This type of activity has for centuries generally been left to politics, executed foremost by governments and political parties. In later decades, however, the future industry has taken up on political parties in formulating and advocating options and suggestions for the future. In the paper we analyse the Future Industry, which we see as serving, feeding into, the emotional streams of contemporary politics and economics. We wish to describe the emotion work the industry undertakes in order to get the attention of its significant others. In the interest of selling beliefs of the future, we suggest that it draws on reason, in the format of science, making its customers sense the pros and cons of the particular future it puts forth. In so doing, it at times may attempt in shaping the future, but what it foremost does, is selling ideas of the future as a commodity. The paper argues that the mapping of global futures to a large extent involves the making of a ‘geopolitics of emotion’. In anticipatory activities, involving the voicing of ‘global problems’ and the presentation of ‘desirable futures’, the cultivation, articulation and management of fear, anxiety, and hope, as well as a reliance on rationality, reason, and evidence, are central components.
Introduction
Authors: Mannitz Sabine , Thompson James
Published: January 2022

This special issue brings together research from various disciplines to not only assess the current state of human rights, aid and development projects, and legitimate governing orders – often framed as factors of human security – but also to critically examine the increasing reliance on measures of compliance and progress in these areas, reflecting the current “world of indicators,” as Richard Rottenburg and Sally Engle Merry put it (2015). While the tools and models currently being utilized are indeed quite powerful, the call for different, more effective kinds of knowledge and evaluative instruments in the face of (allegedly increasing) uncertainty, nevertheless, continues to grow at the same time. Yet neither the various political or humanitarian crises, nor the urgent calls to take action are by any means new. Far from representing an unusual state of affairs, uncertainty is both fundamental to the human condition and the world we inhabit. John Dewey (1938) described the very contingency of social life as the starting point for human reflection, for the generation of meaning and social constructions of evaluation.
La Telerehabilitación como Estrategia de Atención en Salud
Authors: Nuñez Machuca María Fernanda , Meneses Castaño Cyndi Yacira , Penagos Paola Teresa , Beltrán Arias Andres Felipe
Published: January 2022

Introducción: la telerehabilitación es considerada como una estrategia de salud innovadora, la cual busca mejorar el acceso a la salud desde un componente de atención integral, favoreciendo la aplicabilidad de diversos componentes y mejorando las condiciones de salud de los pacientes, con el fin de reintegrarlos a sus diversas actividades, este articulo tiene como objetivo presentar la telerehabilitación como una estrategia en salud. Método: se realizó una búsqueda en diversas bases de datos como, Pubmed, Pedro, EBSCO, Scielo encontrando un total de 235 artículos, de los cuales se seleccionaron 29 artículos y 8 guías clínicas de telerehabilitación en fisioterapia. Resultados:  Se logro identificar en un gran porcentaje los beneficios de la fisioterapia desde la telerehabilitación en pacientes que cursaban con diversas patologías, sin embargo, algunos estudios no recomiendan esta estrategia ya que manifiestan un bajo grado de evidencia. Conclusión: La telerehabilitación en el ámbito fisioterapéutico es una estrategia fundamental para la atención en salud de pacientes cuya condición de salud lo permite, obteniendo resultados satisfactorios desde la mejora de sus capacidades y la vinculación a diversas actividades.

Palabras Clave: Telerehabilitación, Atención Integral de Salud, Fisioterapia, Estrategias de Salud Digital
Designing and Constructing a Novel Artificial Pathway for Malonic Acid Production Biologically
Authors: Gu Shuying , Zhao Zhen , Yao Yonghong , Li Jingen , Tian Chaoguang
Published: January 2022

Malonic acid is used as a common component of many products and processes in the pharmaceutical and cosmetic industries. Here, we designed a novel artificial synthetic pathway of malonic acid, in which oxaloacetate, an intermediate of cytoplasmic reductive tricarboxylic acid (rTCA) pathway, is converted to malonic semialdehyde and then to malonic acid, sequentially catalyzed by a-keto decarboxylase and malonic semialdehyde dehydrogenase. After the systematic screening, we discovered the enzyme oxaloacetate decarboxylase Mdc, catalyzing the first step of the artificially designed pathway in vitro. Then, this synthetic pathway was functionally constructed in cellulolytic thermophilic fungus Myceliophthora thermophila. After enhancement of glucose uptake, the titer of malonic acid achieved 42.5 mg/L. This study presents a novel biological pathway for producing malonic acid from renewable resources in the future.
A Broad m6A Modification Landscape in Inflammatory Bowel Disease
Authors: Nie Kai , Yi Jun , Yang Yuanyuan , Deng Minzi , Yang Yan , Wang Tianyu , Chen Xuejie , Zhang Zhaoyu , Wang Xiaoyan
Published: January 2022

Background and Aims: N6-Methyladenosine (m6A) is the most common post-transcriptional modification on eukaryotic mRNA, affecting the mRNA’s fate. The role of m6A regulation in inflammatory bowel disease is unclear. Here, we investigated the m6A landscape in inflammatory bowel diseases (IBD).

Methods: Eleven human IBD microarray datasets were recruited from the Gene Expression Omnibus database and four were selected as discovery cohorts. An RNA-seq dataset from the Inflammatory Bowel Disease Multi’omics Database was used as a validation cohort. m6A regulators were measured in volunteers’ colonic samples. Consensus clustering and immune scoring were used to estimate the characteristics of m6A regulation in IBD. m6A-related characteristics of different sub-phenotypes, sample sources, and biological therapeutic responses were determined using seven independent datasets.

Results: m6A modification involves methyltransferases (writers), demethylases (erasers), and methylation-reading proteins (readers). A wide interaction exists between m6A regulators and IBD risk genes. The IBD risk loci can also be modified by m6A modifications in the public m6A sequencing data. Furthermore, m6A regulators displayed extensive differential expression in four independent discovery cohorts that share common differential genes (IGF2BP2, HNRNPA2B1, ZCCHC4, and EIF3I). In the validated cohort and enrolled volunteers’ colonic biopsy samples, the differential m6A regulators were reconfirmed. Two clusters of consensus clustering exhibit different immune phenotypes. m6A-modified positions exist in the core IBD immune cytokines. Another set of IBD datasets revealed m6A-related differences across clinical phenotypes, biological samples, and therapeutic response subgroups in IBD patients.

Conclusion: Regulation of m6A methylation is widely involved in IBD occurrence and development. m6A modifications in risk variants, core cytokines, immune cells, and other proteins may deeply influence the pathophysiology and clinical phenotypes. Further studies are needed to determine its role in IBD.
Bridging the Gap: The Importance of TUBA1A α-Tubulin in Forming Midline Commissures
Authors: Buscaglia Georgia , Northington Kyle R. , Aiken Jayne , Hoff Katelyn J. , Bates Emily A.
Published: January 2022

Developing neurons undergo dramatic morphological changes to appropriately migrate and extend axons to make synaptic connections. The microtubule cytoskeleton, made of α/β-tubulin dimers, drives neurite outgrowth, promotes neuronal growth cone responses, and facilitates intracellular transport of critical cargoes during neurodevelopment. TUBA1A constitutes the majority of α-tubulin in the developing brain and mutations to TUBA1A in humans cause severe brain malformations accompanied by varying neurological defects, collectively termed tubulinopathies. Studies of TUBA1A function in mammalian cells have been limited by the presence of multiple genes encoding highly similar tubulin proteins, which leads to α-tubulin antibody promiscuity and makes genetic manipulation challenging. Here, we test mutant tubulin levels and assembly activity and analyze the impact of TUBA1A reduction on growth cone composition, neurite extension, and commissural axon architecture during brain development. We present a novel tagging method for studying and manipulating TUBA1A in cells without impairing tubulin function. Using this tool, we show that a TUBA1A loss-of-function mutation TUBA1AN102D (TUBA1AND), reduces TUBA1A protein levels and prevents incorporation of TUBA1A into microtubule polymers. Reduced Tuba1a α-tubulin in heterozygous Tuba1aND/+ mice leads to grossly normal brain formation except a significant impact on axon extension and impaired formation of forebrain commissures. Neurons with reduced Tuba1a as a result of the Tuba1aND mutation exhibit slower neuron outgrowth compared to controls. Neurons deficient in Tuba1a failed to localize microtubule associated protein-1b (Map1b) to the developing growth cone, likely impacting stabilization of microtubules. Overall, we show that reduced Tuba1a is sufficient to support neuronal migration and cortex development but not commissure formation, and provide mechanistic insight as to how TUBA1A tunes microtubule function to support neurodevelopment.
B1 siRNA Increases de novo DNA Methylation of B1 Elements and Promotes Wound Healing in Diabetic Rats
Authors: Yasom Sakawdaurn , Khumsri Wilunplus , Boonsongserm Papatson , Kitkumthorn Nakarin , Ruangvejvorachai Preecha , Sooksamran Apasee , Wanotayan Rujira , Mutirangura Apiwat
Published: January 2022

Alu (B1 in rodents) hypomethylation, commonly found in diabetes mellitus patients, increases DNA damage and, consequently, delays the healing process. Alu siRNA increases Alu methylation, reduces DNA damage, and promotes cell proliferation.

Aim: To explore whether B1 siRNA treatment restores B1 hypomethylation, resulting in a reduction in DNA damage and acceleration of the healing process in diabetic rat wounds.

Methods: We generated splinted-excisional wounds in a streptozotocin (STZ)-induced type I diabetic rat model and treated the wounds with B1 siRNA/Ca-P nanoparticles to generate de novo DNA methylation in B1 intersperse elements. After treatment, we investigated B1 methylation levels, wound closure rate, wound histopathological structure, and DNA damage markers in diabetic wounds compared to nondiabetic wounds.

Results: We reported that STZ-induced diabetic rat wounds exhibited B1 hypomethylation, wound repair defects, anatomical feature defects, and greater DNA damage compared to normal rats. We also determined that B1 siRNA treatment by Ca-P nanoparticle delivery restored a decrease in B1 methylation levels, remedied delayed wound healing, and improved the histological appearance of the wounds by reducing DNA damage.

Conclusion: B1 hypomethylation is inducible in an STZ-induced type I diabetes rat model. Restoration of B1 hypomethylation using B1 siRNA leads to increased genome stability and improved wound repair in diabetes. Thus, B1 siRNA intervention may be a promising strategy for reprogramming DNA methylation to treat or prevent DNA damage-related diseases.
Role of Ceramides in the Molecular Pathogenesis and Potential Therapeutic Strategies of Cardiometabolic Diseases: What we Know so Far
Authors: Shalaby Youssef M. , Al Aidaros Anas , Valappil Anjana , Ali Bassam R. , Akawi Nadia
Published: January 2022

Ceramides represent a class of biologically active lipids that are involved in orchestrating vital signal transduction pathways responsible for regulating cellular differentiation and proliferation. However, accumulating clinical evidence have shown that ceramides are playing a detrimental role in the pathogenesis of several diseases including cardiovascular disease, type II diabetes and obesity, collectively referred to as cardiometabolic disease. Therefore, it has become necessary to study in depth the role of ceramides in the pathophysiology of such diseases, aiming to tailor more efficient treatment regimens. Furthermore, understanding the contribution of ceramides to the pathological molecular mechanisms of those interrelated conditions may improve not only the therapeutic but also the diagnostic and preventive approaches of the preceding hazardous events. Hence, the purpose of this article is to review currently available evidence on the role of ceramides as a common factor in the pathological mechanisms of cardiometabolic diseases as well as the mechanism of action of the latest ceramides-targeted therapies.
WAFNRLTG: A Novel Model for Predicting LncRNA Target Genes Based on Weighted Average Fusion Network Representation Learning Method
Authors: Li Jianwei , Yang Zhenwu , Wang Duanyang , Li Zhiguang
Published: January 2022

Long non-coding RNAs (lncRNAs) do not encode proteins, yet they have been well established to be involved in complex regulatory functions, and lncRNA regulatory dysfunction can lead to a variety of human complex diseases. LncRNAs mostly exert their functions by regulating the expressions of target genes, and accurate prediction of potential lncRNA target genes would be helpful to further understanding the functional annotations of lncRNAs. Considering the limitations in traditional computational methods for predicting lncRNA target genes, a novel model which was named Weighted Average Fusion Network Representation learning for predicting LncRNA Target Genes (WAFNRLTG) was proposed. First, a novel heterogeneous network was constructed by integrating lncRNA sequence similarity network, mRNA sequence similarity network, lncRNA-mRNA interaction network, lncRNA-miRNA interaction network and mRNA-miRNA interaction network. Next, four popular network representation learning methods were utilized to gain the representation vectors of lncRNA and mRNA nodes. Then, the representations of lncRNAs and target genes in the heterogeneous network were obtained with the weighted average fusion network representation learning method. Finally, we merged the representations of lncRNAs and related target genes to form lncRNA-gene pairs, trained the XGBoost classifier and predicted potential lncRNA target genes. In five-cross validations on the training and independent datasets, the experimental results demonstrated that WAFNRLTG obtained better AUC scores (0.9410, 0.9350) and AUPR scores (0.9391, 0.9350). Moreover, case studies of three common lncRNAs were performed for predicting their potential lncRNA target genes and the results confirmed the effectiveness of WAFNRLTG. The source codes and all data of WAFNRLTG can be freely downloaded at https://github.com/HGDYZW/WAFNRLTG.
Vancomycin-Induced Modulation of Gram-Positive Gut Bacteria and Metabolites Remediates Insulin Resistance in iNOS Knockout Mice
Authors: Aggarwal Hobby , Pathak Priya , Singh Vishal , Kumar Yashwant , Shankar Manoharan , Das Bhabatosh , Jagavelu Kumaravelu , Dikshit Madhu
Published: January 2022

The role of oxidative and nitrosative stress has been implied in both physiology and pathophysiology of metabolic disorders. Inducible nitric oxide synthase (iNOS) has emerged as a crucial regulator of host metabolism and gut microbiota activity. The present study examines the role of the gut microbiome in determining host metabolic functions in the absence of iNOS. Insulin-resistant and dyslipidemic iNOS−/− mice displayed reduced microbial diversity, with a higher relative abundance of Allobaculum and Bifidobacterium, gram-positive bacteria, and altered serum metabolites along with metabolic dysregulation. Vancomycin, which largely depletes gram-positive bacteria, reversed the insulin resistance (IR), dyslipidemia, and related metabolic anomalies in iNOS−/− mice. Such improvements in metabolic markers were accompanied by alterations in the expression of genes involved in fatty acid synthesis in the liver and adipose tissue, lipid uptake in adipose tissue, and lipid efflux in the liver and intestine tissue. The rescue of IR in vancomycin-treated iNOS−/− mice was accompanied with the changes in select serum metabolites such as 10-hydroxydecanoate, indole-3-ethanol, allantoin, hippurate, sebacic acid, aminoadipate, and ophthalmate, along with improvement in phosphatidylethanolamine to phosphatidylcholine (PE/PC) ratio. In the present study, we demonstrate that vancomycin-mediated depletion of gram-positive bacteria in iNOS−/− mice reversed the metabolic perturbations, dyslipidemia, and insulin resistance.
Tra2beta-Dependent Regulation of RIO Kinase 3 Splicing During Rift Valley Fever Virus Infection Underscores the Links Between Alternative Splicing and Innate Antiviral Immunity
Authors: White Luke Adam , Bisom Thomas C. , Grimes Hunter L. , Hayashi Miyuki , Lanchy Jean-Marc , Lodmell J. Stephen
Published: January 2022

Rift Valley fever virus (RVFV) is an emerging pathogen that has potential to cause severe disease in humans and domestic livestock. Propagation of RVFV strain MP-12 is negatively impacted by the actions of RIOK3, a protein involved in the cellular immune response to viral infection. During RVFV infection, RIOK3 mRNA is alternatively spliced to produce an isoform that correlates with the inhibition of interferon β signaling. Here, we identify splicing factor TRA2-β (also known as TRA2beta and hTRA2-β) as a key regulator governing the relative abundance of RIOK3 splicing isoforms. Using RT-PCR and minigenes, we determined that TRA2-β interaction with RIOK3 pre-mRNA was necessary for constitutive splicing of RIOK3 mRNA, and conversely, lack of TRA2-β engagement led to increased alternative splicing. Expression of TRA2-β was found to be necessary for RIOK3’s antiviral effect against RVFV. Intriguingly, TRA2-β mRNA is also alternatively spliced during RVFV infection, leading to a decrease in cellular TRA2-β protein levels. These results suggest that splicing modulation serves as an immune evasion strategy by RVFV and/or is a cellular mechanism to prevent excessive immune response. Furthermore, the results suggest that TRA2-β can act as a key regulator of additional steps of the innate immune response to viral infection.