bluuebunny/crossref_metadata_2025 huggingface dataset:
Efek Musik Suara Alam (Nature Sounds Music) terhadap Penurunan Kecemasan pada Pasien Pasca Stroke
Authors: Wulandari Tri suraning , Kurniawati Ratna , Azizatul Ilmiyah Vina
Published: August 2023

Stroke merupakan suatu kondisi yang diakibatkan oleh terganggunya aliran darah serebral yang menyebabkan kerusakan neurologis. Kerusakan neurologi tersebut menjadi sumber kecemasan sampai bahkan kematian.  Prevalensi kecemasan pada stroke (post stroke anxiety/PSA) sebesar 10,9% dan terbanyak terjadi pada laki-laki dengan tingkat kecemasan rendah, sedang hingga berat. Kecemasan pasca stroke tersering muncul ketika aktivitas sehari-harinya tidak mampu dilakukan. Dampak kecemasan pasca stroke  yang dialami lama, berpengaruh terhadap kualitas hidupnya. Pemberian musik suara alam (piano, suara burung, suara gemericik air) menjadi pilihan mengatasi kecemasan pasca stroke.  Penelitian bertujuan untuk mengetahui efek musik suara alam (nature sounds music) dalam menurunkan kecemasan pada pasien pasca stroke. Penelitian quasi eksperimental  dengan one group pre test  and post test design. Sampel penelitian adalah pasien pasca stroke yang sudah lebih dari 6 bulan dan tidak mampu melakukan aktivitas sehari-hari. Teknik pengambilan sampel menggunakan purposive sampling. Teknik pengambilan data dengan wawancara dan observasi, kuesioner menggunakan  Hamilton Rating Scale for Anxiety (HRS-A) . Analisa data menggunakan uji paired t. Hasil Penelitian dari 17 responden, 11 responden dengan tingkat kecemasan sedang dengan 64,7% dan sisanya mengalami tingkat kecemasan berat dengan 35,3%, sedangkan uji beda diperoleh nilai p sebesar 0,000 yang bermakna dan terdapat perbedaan kecemasan baik sebelum atau sesudah diberikan musik suara alam (nature sounds music). Nilai mean pada post-test (18,53) mengalami penurunan dibanding pada pre-test (21,53). Kesimpulan musik suara alam (nature sounds music) efektif untuk mengatasi masalah keperawatan kecemasan pasien pasca stroke
Determinan Kepatuhan Penerapan Protokol Kesehatan Dalam Upaya Pencegahan Penularan COVID-19 di Pasar Tradisional Ciputat Kota Tangerang Selatan
Authors: Manggala Yudha Agung , Ramadhan Gaung Eka
Published: August 2023

Virus Corona adalah virus RNA rantai positif yang beruntai tunggal yang tidak tersegmentasi. Virus-virus corona termasuk dalam ordo Nidovirales, keluarga Coronaviridae, dan sub-keluarga Orthocoronavirinae, yang dibagi menjadi kelompok (marga) α, β, γ, dan δ sesuai dengan karakteristik serotipik dan  genomiknya. Virus Corona termasuk dalam genus Coronavirus dari keluarga Coronaviridae ini dinamai sesuai dengan tonjolan berbentuk karangan bunga di selubung virus. Penelitian ini bertujuan untuk melihat determinan kepatuhan penerapan protokol kesehatan dalam upaya pencegahan penularan COVID-19 di pasar tradisional Ciputat Kota Tangerang Selatan. Metodologi penelitian yang digunakan dalam penelitian yaitu kuantitatifDesain penelitian yang digunakan cross sectional (Potong lintang). Penelitian ini dilakukan pada Juli- Agustus 2020 dengan 77 sampel, teknik pengambilan sampel yaitu random sampling. Analisa data menggunakan univariat dan bivariate dengan uji chi- square. Hasil analisis menunjukkan terdapat hubungan yang bermakna antara pengetahuan dengan kepatuhan penerapan protokol kesehatan dalam pencegahan penularan COVID-19 dengan nilai (P Value= 0,002), Perceived Susceptibility (Persepsi Kerentanan) (P Value 0,002), Perceived Severity (Persepsi Keparahan) (P Value= 0,003), Persepsi Barrier (Hambatan) (P Value= 0,005). Penelitian ini diharapkan dapat menjadi masukan bagi Dinas Kesehatan Kota Tangerang Selatan dalam mengambil langkah-langkah strategis upaya pencegahan penularan COVID-19 di Pasar Tradisional Ciputat Kota Tangerang Selatan.
Efektivitas Massage untuk Meningkatkan Produksi Air Susu Ibu (ASI) pada Ibu Postpartum
Authors: Kartini Monica , Kusumadewi Berlian Nurtyashesti
Published: August 2023

Pemberian Air Susu Ibu (ASI) pada dua tahun pertama kehidupan bayi meningkatkan kesehatan, pertumbuhan, perkembangan dan kecerdasan anak, serta memberi perlindungan terhadap berbagai penyakit. Namun demikian, seringkali dijumpai berbagai hambatan, baik dari sisi ibu maupun kurang optimalnya peran tenaga kesehatan dalam memberikan perawatan untuk ibu postpartum, sehingga target pemberian ASI secara dini dan eksklusif untuk bayi belum tercapai. Penelitian ini bertujuan untuk mengidentifikasi, mengevaluasi dan mensintesis literatur mengenai metode-metode massage dan pengaruhnya terhadap produksi ASI dan depresi ibu postpartum. Dengan menggunakan metode literature review, artikel-artikel penelitian ditelusur di database Pubmed dan GARUDA untuk artikel yang terbit tahun 2013-2023 dengan menggunakan kata kunci: massage, milk production, breast milk, breastfeeding, postpartum. Hasil penelusuran awal ditemukan 122 artikel, dan setelah dilakukan pengecekan dan appraisal, terdapat 22 artikel yang relevan untuk diakukan review. Terdapat berbagai jenis metode massage pada ibu postpartum efektif untuk meningkatkan produksi ASI, dan yang paling banyak dilakukan adalah pijat oksitosin, baik hanya pijat oksitosin saja maupun dikombinasikan dengan teknik lain seperti acupressure, pijat marmet, pijat oketani, terapi music maupun pemijatan dengan menggunakan lavender essential oil. Massage yang dilakukan pada ibu postpartum akan membuat ibu merasa nyaman, mengurangi depresi dan sensasi nyeri, membuat tubuh lebih rileks, menurunkan hormone stress, meningkatkan hormone prolactin dan oksitosin, serta meningkatkan produksi ASI. Pemijatan yang dilakukan sebanyak dua kali sehari (pagi dan sore) dengan durasi 10-15 menit atau 30-60 menit selama 3-14 hari efektif untuk meningkatkan produksi ASI ibu postpartum dan menurunkan depresi.
PEMILIHAN KOMPOSISI BATUBARA GC-8 ATAU SMM UNTUK MENDAPATKAN KUALITAS DAN BIAYA PRODUKSI YANG OPTIMUM DI PT. VINYSEA
Authors: Sulistyo Arif Budi , Rinaldi Aldi
Published: August 2023

PT. Vinysea adalah perusahaan terkemuka di Indonesia yang bergerak pada industri baja. Salah satu bahan baku utama adalah batubara, yang diolah dengan pemanasan tinggi menjadi kokas. Selanjutnya kokas menjadi bahan baku proses pembuatan baja dalam blast furnace. Kualitas batubara sangat menentukan mutu dari kokas yang dihasilkan.   Meskipun Indonesia memiliki sumber daya batubara yang berlimpah, dengan jumlah cadangan lima terbesar di dunia, namun memiliki kualitas yang rendah. Untuk mendapatkan kualitas yang bagus diperlukan pengembangan percampuran jenis batubara sebagai bahan baku pembuatan kokas, antara batubara lokal dan import, yang dikenal dengan metode coal blending. Penelitian ini bertujuan untuk mendapatkan kualitas kokas yang baik berdasarkan komposisi coal blending dari dua jenis batubara sehingga menghasilkan kokas dengan kandungan kimia yang sesuai dengan standar kualitas secara komersial. Setiap variasi komposisi dilakukan analisa proksimat (kadar air, kadar zat terbang dan kadar abu) untuk memverivikasi Certificate Of Analysis dari supplier, kemudian menghitung besarnya biaya yang dibutuhkan dalam pembelian setiap batubara tersebut. Dari tujuh variasi komposisi didapatkan komposisi SMM dan GC-8 sebesar 40/60 yang memenuhi spesifikasi dengan biaya yang paling rendah, yaitu $155.090/ton.
USULAN PENENTUAN WAKTU BAKU PADA OPERATOR PACKING FOLDING KAIN TETORON RAYON DENGAN METODE STOPWATCH
Authors: Krisnaningsih Erni , Dwiyatno Saleh , Sasongko Roland
Published: August 2023

Pengukuran kerja merupakan metode untuk menentukan waktu yang dibutuhkan oleh  karyawan yang mempunyai kualifikasi yang baik dalam melaksanakan pekerjaannya untuk bekerja pada keadaan normal dan wajar. Pengukuran waktu kerja menggunakan jam henti (Stopwatch ) diperkenalkan Frederick W. Taylor pada abad ke-19. Metode ini baik untuk diaplikasikan pada pekerjaan yang singkat dan berulang (repetitive) [10], [1].   Tujuan dari penentuan waktu baku antara lain   sebagai  usulan  bagi perusahaan  bagi  penentuan rencana dan jadwal kerja, Standar biaya dan penentuan kebutuhan budget, estimasi biaya produk, rencana kebutuhan mesin dan penentuan upah standar operator dan lain-lain. Penentuan waktu baku dengan metode stopwatch efektif diterapkan pada industri skala [1].Pengukuran waktu baku pada  PT. Cipta Lestari Ideanusa  dilaksanakan secara langsung dengan jam henti (stopwatch) dari hasil perhitungan terhadap waktu baku pada operator Packing Folding kain Tetoron  dengan mempertimbangkan tingkat keyakinan  (k) sebesar  95% = 2, tingkat ketelitian sebesar 0,05 serta  faktor penyesuaian dengan metode westinghouse system rating  dan pertimbangan objektif serta faktor kelonggaran sebesar 40%, maka diperoleh waktu  baku 152,98  detik atau 153 detik per unit produk. Dari hasil pengukuran waktu baku untuk menyelesaikan suatu siklus pekerjaan akan dipergunakan sebagai waktu standar penyelesaian suatu pekerjaan bagi semua pekerja yang akan melaksanakan pekerjaan yang sama dan dapat dijadikan sebagai acuan dalam penentuan sikap kerja 5S [6].
The Correlation between Study Behavior and Depression among Thai and International High School Students in Bangkok
Authors:   Suksanari School, Bangkok, Thailand, Akravuthiyarn Kotchanada , Thebpatipat Chananon ,   Bangkok Patana School, Bangkok, Thailand, Vootidetgumjorn Photsawee ,   Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand
Published: August 2023

Depression significantly impacts people’s behavior and relationships with their loved ones by negatively influencing their emotions and actions. In Bangkok, there is an increasing prevalence of depression among Thai and international high school students due to variances in study habits. Thus, we conducted cross-sectional survey research to determine the correlation between study behavior and depression in Thai high school students. An online questionnaire was employed in this study to gather information on the study habits, including time management, of Thai and international students. To determine if study habits among Thai and international students are associated with depression, we employed the standard deviation, Ttest, and Pearson Correlation Coefficient. According to the information we have obtained, we have discovered that Thai high school students are more likely than international students to experience depression, which strongly shows that their academic curriculum is significantly more strenuous and stressful (p-value of 5.58). The outcomes of this study should aid in advancements in education and mental health research by promoting therapies, educational practices, and interventions by analyzing teenage problems, academic stress, and mental health.
Pattern of Poisoning and Fates of the Female Patients Admitted in the Medicine Wards of Rajshahi Medical College Hospital
Authors:   Nursing Instructor, Rajshahi Nursing College, Rajshahi, Bangladesh., Begum Rowshan Ara , Saha Ashees Kumar ,   Nursing Instructor, Pabna Nursing College, Pabna, Bangladesh., Haque Dr. Md. Jawadul ,   Professor & Adjunct Faculty Member, Dept. of Public Health, Northern University, Rajshahi, Bangladesh.
Published: August 2023

This study aimed to investigate the pattern of poisoning and the fates of female patients admitted to the medicine wards of Rajshahi Medical College Hospital. A retrospective analysis was conducted on data collected from 300 female patients. The study examined various factors, including age distribution, occupation, educational background, family structure, religious affiliation, and residential location. Statistical analyses were performed to determine the relationship between these factors and the pattern and outcomes of poisoning incidents. The results showed that the largest age group affected by poisoning incidents was between 20 and 39 years, comprising 67.7% of the population. Suicidal poisoning was the most common pattern, accounting for 95.7% of the cases. In terms of the types of poisoning, insecticides (OPC) were the most frequently reported, representing 60.0% of the incidents. Pesticides kept in the house were the primary source of poisoning, reported in 72.7% of the cases. Regarding the fates of the victims, 66.3% of the patients were completely cured, 30.0% experienced some disability, and 3.7% sadly succumbed to death. Analysis of age groups revealed that the percentage of victims completely cured was highest in the age group of 40-59 years (76.5%), while the percentage of victims cured with some disability was highest in the age group of 60+ years (71.4%). The relationship between age group and the fate of the victims was found to be statistically significant (χ2=17.49, df=6, p<0.05). Moreover, the analysis showed a significant relationship between the type of poisoning and the fate of the victims (χ2=1.141, df=8, p<0.001). Among different types of poisoning, insecticide (OPC) poisoning resulted in the highest percentage of complete cure (78.3%), while sedative poisoning had the lowest percentage of victims with some disability (11.8%). This study provides valuable statistical insights into the pattern of poisoning and the fates of female patients in a medical setting. The findings emphasize the need for targeted prevention strategies, early medical intervention, and comprehensive support services to improve outcomes and reduce the incidence of poisoning incidents. These results can inform healthcare providers, policymakers, and public health professionals in developing effective interventions and policies to address poisoning incidents among female patients.
Intestinal Intussusception Secondary to Appendiceal Mucocele, Report of a Case in A 53-Year-Old Female
Authors:   Zone General Hospital #33 Monterrey, Nuevo León., Jocelyn Unzueta , Miguel Amezcua ,   Regional Hospital 270 Reynosa, Tamaulipas.
Published: August 2023

Appendiceal intussusception is defined as the invagination of a portion of the appendix into its own lumen or into that of the cecum. In adults, the most common etiology is endometriosis (33%), followed by appendiceal mucocele (19%) and appendiceal inflammation (19%) [4]. Symptoms may be absent or mild. Lower abdominal pain or mass may be confused with appendicitis or tuboovarian mass in women. The diagnosis of appendiceal mucocele is often difficult preoperatively, even with the use of imaging. The definitive diagnosis is by histopathology. Treatment is surgical resection with care. Do not spill the contents, to prevent peritoneal pseudomyxoma with a poor prognosis [2]. In the present work, a 53-year-old female is reported with a 72-hour evolution of abdominal pain in the mesogastrium, accompanied by nausea and vomiting, normal vital signs on physical examination, without acute abdominal symptoms, with laboratories within normal parameters. , a computed tomography of the abdomen is taken which reports extensive intussusception at the ileocecal level which extends to the transverse colon, adjacent neoplastic etiology must be ruled out. An exploratory laparotomy was performed, finding intussusception of the ileum in the transverse colon with a 5 x 5 cm blind sentence, for which it was decided to perform a right hemicolectomy + mechanical lateral ileotransverse anastomosis. Patient with favorable evolution, hospitalized for 6 days.
International Trade and Economic Growth Nexus. Empirical Evidence from Uganda
Authors:   Mountains of Moon University, Erem Dr Emmanuel , Patrick Kato S.B. ,   Mountains of Moon University, Rwambale Kadhiri ,   Mountains of Moon University, Kisembo Robert ,   Mountains of Moon University
Published: August 2023

Exports, imports, and foreign direct investment were used as proxies in this study to examine the relationship between global trade and economic growth in Uganda from 1988 to 2018. Exports, imports, and foreign direct investment all strongly positively and significantly correlated with economic growth, according to empirical evidence. Unit root tests were performed using the Augmented Dickey Fuller test, and the results showed that all variables started out nonstationary but subsequently became constant. Due of the long-term correlations between the variables, cointegration was established using the Engle Granger Cointegration test. The variables' rate of adaptation to the long run within a one-year lag was 57%. Collectively, foreign investment, imports, and exports contribute for 77% of changes in the country's GDP. 23% of the variations in the growing size of the economy were caused by extra factors in the error term that were not included in the model. Because the F statistic was considered statistically significant, exports, imports, and foreign direct investment all have a significant impact on economic growth in the short run. For the sake of making policy suggestions, it is encouraged to use export marketing strategies to grow Uganda's exports and to give domestic businesses tax breaks to improve the way they perform. A welcoming investment atmosphere must also be provided for Uganda to attract foreign direct investment.
Does Work Motivation Mediate the Effect of Work Discipline on Employee Performance? Evidence from Indonesian Hotel Employees
Authors:   Management Department, Faculty of Economic and Business, Universitas Brawijaya, Indonesia., Mentari Karina Rizka , Armanu Armanu ,   Management Department, Faculty of Economic and Business, Universitas Brawijaya, Indonesia., Helmy Djawahir Achmad ,   Management Department, Faculty of Economic and Business, Universitas Brawijaya, Indonesia.
Published: August 2023

This study aims to determine the effect of work discipline on employee performance with work motivation as a mediation. The population in this study were all employees working at Swiss-Belinn Hotel Malang, and the sampling method used was the census method of 104 respondents. The data analysis method used is Partial Least Square (PLS). The study results show that work discipline positively and significantly affects employee performance. Work discipline is proven to have a positive and significant effect on work motivation. Work motivation also has a positive and significant effect on employee performance. Work motivation can mediate the relationship between work discipline and employee performance.
Random Versus Pseudorandom Physics
Authors:   Ph.D. Wayne State University, Detroit, Michigan, Brierly Joseph EL
Published: August 2023

Physical processes can be compared to a lottery. This article compares natural physical events to artificial ones created by man’s intervention. Manmade physical processes like a lottery cannot be perfectly random. Pure random behavior can only occur in nature without manmade intervention. Said another way all manmade lotteries have a nonrandom bias. The best that can happen is to contrive a lottery that converges on pure random behavior. This article explains why manual intervention invariably results in pseudorandom bias. In this article the label pseudorandom applies to any process occurring in nature that requires man’s intervention. The article asserts that Repulsion Gravity can be viewed as the element in nature that causes true randomness. Physical processes like Brownian Motion represent pure random behavior. This article compares random to pseudorandom behavior.
Influence of S-Ketamine, at low Doses, on the Electroencephalogram - BIS Suppression Rate: A Randomized Clinical Trial
Authors:   Hospital São Carlos - Rede D’Or, Ave. Pontes Vieira, 2531, São João do Tauape, Fortaleza, CE, 60130-241, Brazil, Nunes Rogean Rodrigues , Akamine Filipe Mitsuo ,   Hospital São Carlos - Rede D’Or, Ave. Pontes Vieira, 2531, São João do Tauape, Fortaleza, CE, 60130-241, Brazil, Meireles Bruno Rocha ,   Hospital Geral de Fortaleza, Fortaleza, CE, Brazil
Published: August 2023

Objective: To evaluate the influence of low doses of S-ketamine, during total intravenous anesthesia, on the suppression rate (SR) induced during total intravenous anesthesia (TIVA) by deepening the anesthetic plane. Methods: A triple-blind clinical trial was conducted with 20 patients who underwent elective operations under general anesthesia, randomly allocated into two groups, CG (control: 0.9% saline) and CGS (s-ketamine: 0.2 mg.kg-1). Each group was assessed at M0 (immediately before pre-oxygenation), M1 (3 minutes after SR stabilization) and M2 (3 minutes after infusion of s-ketamine or 0.9% saline). Bispectral index (BIS), electromyography, and SR were recorded at each moment. Results: There were no statistically significant changes regarding BIS and EMG from M1 to M2. There was also no indication of a significant difference between the average SR values concerning the factors group and moment, jointly (p=0.499), and separately (G1 and G2, p=0.812 and p=0.923). Conclusions: Low doses of s-ketamine were insufficient to determine changes in SR values, validating this important electroencephalographic parameter. Significance: The study findings reinforce that low doses of s-ketamine do not invalidate the SR values
Actitudes sociales hacia los delincuentes sexuales y su relación con la orientación a la dominancia social
Authors: Fernández Huelga Claudia , Moral Jiménez María de la Villa
Published: August 2023

Las actitudes sociales hacia delincuentes sexuales están sujetas a la influencia de mitos o prejuicios y el delito puede ser visto como un ataque a la jerarquía social. En el presente estudio se relacionan ambos constructos: las actitudes de la población y la preferencia por mantener una sociedad jerárquica, es decir, la orientación a la dominancia social. Participaron 322 sujetos, elegidos mediante una selección no probabilística, con edades comprendidas entre los 18 y los 65 años (M = 32.52, DT = 13.806), a los que se aplicaron escalas sobre actitudes hacia los delincuentes sexuales y su tratamiento (ATS-21 y ATTSO), así como sobre dominancia social (SDO). Se ha hallado que las personas con mayor orientación a la dominancia social presentan actitudes más negativas hacia los delincuentes sexuales y su tratamiento. Puntúan más alto en dominancia social los hombres, las personas con una afiliación política de derechas y las religiosas. Estos dos últimos grupos tienen actitudes más negativas hacia los delincuentes sexuales, junto con las mujeres, las personas con bajo nivel educativo y las mayores de 30 años. Los hallazgos pueden explicar por qué las personas pueden ser o no defensoras de la rehabilitación y reinserción de delincuentes sexuales dependiendo de ciertas características sociodemográficas y su nivel de dominancia social.
Adaptive reactivity of cerebral energy metabolism in individuals with vibration disease and diabetes mellitus type 2
Authors: Shevchenko Oxana I. , Lakhman Oleg L.
Published: August 2023

Introduction. Knowledge of adaptation options on the example of the reactivity of cerebral energy metabolism (CEM) under stress is important for determining the features of the development of vibration disease in the comorbid course of diabetes mellitus type 2 (DM2), the success of recovery in the rehabilitation period.
Objective of the study was adaptation options using the example of cerebral energy metabolism reactivity under stress in individuals with vibration disease caused by the simultaneous effect of local and general vibration (SLGV) and type 2 diabetes mellitus.
Materials and methods. Features of adaptation under stress were studied by the method of neuroenergy mapping with the measurement of the level of constant potential (DC-potential level). Groups were formed: I (n = 94) – patients with SLGV, II (n = 38) – with comorbid pathology (SLGV and DM 2), III (n = 39) – with DM2.
Results. More than 60% of all examined patients were established to be characterized by a rigid response to physical and emotional stress. Adequate CEM recovery reaction in the posthyperventilation period in the predominant number of cases was observed only in group I. In patients of group II, perverse (39%) and rigid (32%) reactions of recovery of DC-potential level were more common, group III – perverted and excessive response (33 % and 28%, respectively), characterizing the disorder of physiological adaptation in the presence of DM2.
Limitations. The limitations of the work are presented in the form of a brief description of working conditions, lack of study of the impact of industrial noise on cerebral hemodynamics, insufficient depth of the study of foreign literature materials on the issue under study.
Conclusion. The comorbid course SLGV and DM2 causes a persistent impairment of adaptation to stress, which is confirmed by the rigidity of the
DC-potential level in response to hyperventilation, quick verbal response test, and the inadequacy of response during the restoration of neuroenergy exchange in the posthyperventilation period.
Evaluation of the cytogenetic activity of the food dye Azorubine in a micronucleus test in mice
Authors: Yurchenko Valentina V. , Akhaltseva Lyudmila V. , Konyashkina Mariya A. , Yurtseva Nadezda A.
Published: August 2023

Introduction. Azorubine E122 (Carmoisine, Food Red 3) monoazo dye is used in the manufacture of desserts, caramels, sweets, marmalades, ice cream, alcoholic and non-alcoholic drinks, etc. The safety assessment of food additives includes the study of genotoxic potential. At the same time, for substances with a high or a small but long-term exposure (including food additives), in vivo tests are required.
Materials and methods. The genotoxic activity of aqueous solutions of synthetic food azo dyes E122 Azorubin was studied by the micronuclear method on bone marrow cells in mice (males, hybrids F1 CBA × C57Bl6/j). The studied substances were injected into the stomach of mice at doses of 250–2000 mg/kg twice with an interval of 24 hours, with the preparation of bone marrow preparations 24 hours after the last administration. The frequency of micronucleated (MN) polychromatophilic erythrocytes (PCEs) was estimated on the base of the results of the analysis of 4000 PСЕ. The proportion of PСE among all red blood cells was determined by analyzing 500 cells per animal.
Results. There was no statistically significant increase in the frequency of PCE with MN over the current control with a double administration of Azorubine in all studied doses. After exposure at doses of 1000 and 2000 mg/kg, the incidence of MN PCEs slightly exceeded the upper limit of the 95% CI of the accumulated negative control and the effect was dose-dependent and statistically significant, which does not allow recognizing the answer as clearly negative.
Limitations of the study are due to the methodology of the test: only cytogenetic disorders in a single tissue were analyzed under conditions of double enteral administration of the studied sample.
Conclusion. An analysis of the frequency of MN PCEs in the bone marrow of mice after a double injection of Azorubine at doses of 250–2000 mg/kg made it possible to qualify the result of the experiment as uncertain.
Morphological changes in the liver parenchyma in rats under subacute acrylamide intoxication and the possibility of their preventive treatment
Authors: Baygildin Samat S. , Repina Elvira F. , Karimov Denis O. , Bakirov Ahat B. , Gimadieva Alfiya R. , Khusnutdinova Nadezhda Yu. , Timasheva Gulnara V. , Akhmadeev Aidar R. , Smolyankin Denis A.
Published: August 2023

Introduction. Acrylamide, used in industry, is also formed in foods during high temperature processing. Acrylamide has a toxic effect on the nervous, reproductive, and other systems of the body, due to carcinogenic and genotoxic properties. Considering sufficiently serious threat of acrylamide to human health, it is relevant to carry out further fundamental research to study the mechanism of its impact on the body and the possibility of treatment of lesions caused by it.
The aims of this study is to assess morphological changes in the liver of experimental animals under acute acrylamide intoxication and study the possibility of their preventive treatment with complex compounds based on oxymethyluracil.
Materials and methods. Experimental studies on the subacute effects of acrylamide at a dose of 20 mg/kg on the histological structure of the liver were carried out on outbred female rats. The efficiency of preventive administration of complex compounds of oxymethyluracil with ascorbic acid, with sodium succinate and acetylcysteine ​​was also studied.
Results. Exposure to acrylamide for 28 days at a dose of 20 mg/kg of body weight in experimental rats, has been established to cause minor morphological changes in the structure of the liver: only focal cellular infiltrates were found in the centrilobular zones. In groups of rats that received preventive treatment with complex compounds based on oxymethyluracil, no formation of infiltrates and other pathological changes was observed.
Limitations. Limitations of the study are related to implementation of experimental studies of the pathomorphological changes in the liver of experimental animals using only one dose of acrylamide - 20 mg per kg of body weight during one limited period (28 days).
Conclusion. Exposure to acrylamide for 28 days at a dose of 20 mg/kg of body weight causes minor morphological changes in the structure of the liver in experimental rats. For the first time, the effectiveness of prophylactic correction of the toxic effect of acrylamide with complex compounds of oxymethyluracil with ascorbic acid, sodium succinate and acetylcysteine, which showed a certain protective effect on the liver, was studied.
Cultural, morphological and biochemical properties of Salmonella typhimurium indicator bacteria used in the Ames test and their applicability for the assessment of the test system quality
Authors: Egorova Olga V. , Mikheev Pavel V. , Trukhina Galina M. , Ilyushina Nataliya A.
Published: August 2023

Introduction. The Ames test has been widely used to study the mutagenicity of chemicals. In view of the implementation of a quality management system in the test facilities, the cultural, morphological and biochemical properties of strains used in the Salmonella/microsome test system were studied. An assessment of their applicability as additional characteristics of quality of the tester strain was made.
Materials and methods. The study of cultural and morphological characteristics of S. typhimurium strains was carried out using the commercial media.
The biochemical properties of S. typhimurium cultures were evaluated using a Vitek-2 system.
Results. Studies have shown that the procedure of marker verification for confirming the reference properties of tester strains, in addition to evaluation of the spontaneous mutation level and phenotypic characteristics (-his phenotype, the presence or absence of the R-factor plasmids, rfa- and ∆uvrB mutations), can be extended by periodically assessing their biochemical properties. Most of the biochemical characteristics of bacteria of the Salmonella typhimurium serovar are inherent for tester strains. Compared to the wild-type bacteria atypical features of tester strains are a negative reaction in the hydrogen sulfide production test, positive activity of tyrosine arylamidase, the ability to utilize 5-keto-D-gluconate, unstable activity of alpha-galactosidase. Differential selective media used to maintain wild-type Salmonella cultures are not universal for the growth of strains of the Salmonella/microsome test system. When choosing media for cytotoxicity, survival, or sterility assessment, it is necessary to take into consideration the growth characteristics of the Salmonella tester strains on different media: the ability to grow on selective media decreases in the series of Endo-agar > Salmonella Shigella -agar > Bismuth-sulfite agar > Ploskirev’s agar.
Limitations. The research is limited to the study of cultural, morphological and biochemical characteristics of S. typhimurium, but not Escherichia coli.
Conclusion. The described cultural and morphological properties of tested strains on different media can be used to assess cytotoxicity/survival of treated cultures performing studies according to OECD 471. The use of additional biochemical markers of authenticity and morphological properties of tester strains will help to ensure the quality of studies using the Ames test in the processes of conservation, reproduction, and routine testing.
Open Access: diseminación del conocimiento científico y académico
Authors: Armesto Núñez Dilcia D.
Published: August 2023

Con el surgimiento de la imprenta, a mediados del siglo XV, invento que vino a revolucionar la expansión y distribución del conocimiento, trajo como consecuencia avances significativos para la publicación y difusión de ideas en diversas disciplinas...
Una década de acreditación de programas de educación superior en México
Authors: González-Juárez Graciela
Published: August 2023

La evaluación educativa ha mostrado un desarrollo desigual en las instituciones educativas en el país, en el caso de la acreditación de programas educativos, ha empezado a discutirse en dos ejes: los procesos de acreditación programa educativo y en los efectos de la acreditación sobre el programa educativo. El objetivo fue analizar la productividad académica reportada durante la década de 2011 a 2021. Es una investigación documental, descriptiva, transversal y prospectiva. Los resultados obtenidos de los 42 documentos analizados se distribuyeron en los referidos a los procesos de acreditación de la calidad y en los efectos de la acreditación sobre el programa educativo. Los resultados muestran que este campo joven de la evaluación educativa tiene una producción académica gris, basada en congresos especializados, principalmente. Se identifican dos líneas de investigación generales: los procesos de acreditación de la calidad en las instituciones educativas y los efectos de la acreditación en el programa educativo y sus actores. Adherida a la rendición de cuentas, alguna investigación educativa se publica en sitios web oficiales. Se encuentra centralizada en la región metropolitana, principalmente. En otras líneas de trabajo, es necesario recuperar las experiencias de los pares evaluadores y sus efectos en la acreditación de calidad.
Decoding the Future of Finance: An Examination of Asset Tokenization and Web 3.0
Authors: Shi Jianzheng
Published: August 2023

This paper explores the rapidly evolving landscape of asset tokenization within the broader context of Web 3.0. Asset tokenization, the process of converting rights to an asset into a digital token on a blockchain, presents a transformative opportunity for various sectors, especially finance. This paper delves into the technicalities of asset tokenization, discusses its potential impacts, and forecasts its role in the future of digital economies. It argues that asset tokenization, fueled by the advancements in Web 3.0, will play a pivotal role in the democratization of finance, reducing entry barriers, and creating more efficient and transparent systems.
Identifikasi Jalur Evakuasi Bencana Alam Dan Non Alam Di Gedung Biro Pusat Administrasi Universitas Negeri Medan, Sumatera Utara
Authors: Matondang Muhammad Farouq Ghazali , Damanik Muhammad Ridha Syafii , Situmorang Amrita Ridha Syafii , Sinbutar Angg Violin , Fadilah Rayhan Ridha Syafii
Published: August 2023

Bencana alam dapat mengancam keselamatan dan kesejahteraan masyarakat di berbagai daerah. Pada khususnya, gedung-gedung perkantoran dan institusi pendidikan perlu memiliki jalur evakuasi yang tepat untuk mengurangi risiko dan memberikan perlindungan bagi penghuninya. Penelitian ini bertujuan untuk mengidentifikasi jalur evakuasi bencana alam dan non alam di Gedung Biro Pusat Administrasi Universitas Negeri Medan, Sumatera Utara. Metode yang digunakan meliputi pendekatan kualitatif, survei lapangan, analisis perencanaan kebencanaan, dan wawancara dengan pihak terkait. Hasil penelitian menunjukkan bahwa gedung ini tidak memiliki beberapa jalur evakuasi yang telah ditentukan sesuai dengan peraturan kebencanaan yang berlaku. Jalur-jalur evakuasi ini melibatkan tangga,pintu keluar, dan jalur keluar alternatif yang dapat digunakan dalam berbagai skenario bencana. Selain itu, penelitian ini juga mengidentifikasi beberapa area yang memerlukan perbaikan atau peningkatan dalam hal keamanan dan aksesibilitas evakuasi. Temuan penelitian ini dapat menjadi dasar untuk perbaikan dan peningkatan rencana kebencanaan di Gedung Biro Pusat Administrasi Universitas Negeri Medan. Diharapkan hasil penelitian ini dapat menjadi panduan bagi pihak terkait dalam mengoptimalkan jalur evakuasi, meningkatkan kesadaran bencana, serta memperkuat kapasitas respon dalam menghadapi bencana alam dan non alam di lingkungan kampus.
Neonatologie in tijden van big data, machine learning en artificiële intelligentie: potentiële toepassingen gebruikmakend van continu gemonitorde vitale parameters. Een systematische review.
Authors: Schögler A. , Smets K.
Published: August 2023

Neonatology in times of big data, machine learning and artificial intelligence: potential applications using continuously monitored vital signs. A systematic review

Background: At the neonatal intensive care unit vital signs are continuously monitored, which yields a huge amount of values. At the moment, these are mainly used in a real-time bedside manner when values cross fixed boundaries triggering an alarm, also general trends are followed. Subtle patterns which may be a first sign of disease or clinical condition can be missed. By using scientific revolutions as big data, machine learning and artificial intelligence it may be possible to extract much more information from this amount of data.

Objective: We make an overview of possible applications more thoroughly using continuously monitored vital signs in the NICU, developed by using scientific evolutions as big data, machine learning or artificial intelligence.

Methods: A systematic search is carried out in four databases, PRISMA-guidelines are followed. The retained articles are analysed regarding the topic, the used methods, the results and possible implementation.

Results: We included 35 articles. The investigated topics and used methods were very diverse. Only a minority of possible applications are already studied enough to enable use in daily practice.

Conclusion: Applications using continuously monitored vital signs, developed by using scientific evolutions as big data, machine learning and artificial intelligence are promising and a lot of research is being carried out. Nevertheless, implementation is still very limited.
The Influence of Transformational Leadership on Indigenous Family Businesses: A Case Study of Zimbabwe Indigenous Family Businesses
Authors: Shumbambiri Gregory
Published: August 2023

The objective of the study was to establish the influence of transformational leadership in enhancing sustainable organizational growth for family-owned businesses in Zimbabwe. Transformational leadership is a management technique whose major purpose is to improve new ways of growing and sustaining the organization’s goals and aspirations. The study focused on family-owned businesses in Harare Metropolitan Province with the population for the study comprising owners, managers and employees of the family businesses. The research assumption was that family businesses that use elements of transformation leadership are more likely to survive after the death of the founding owner. Family-owned businesses creation, development and life span are basic to the achievement of the worldwide economy. Not much work has been done in the context of Zimbabwe’s family businesses, more so with emphasis on transformational leadership for family businesses in particular. The study revealed that transformational leadership style influences the growth of their family-owned businesses as transformational leadership style motivates positive changes in the followers. The study also revealed that transformational leadership elevates the interests of employees and stir employees to look beyond their own self-interests for the good of the company.
Tratamento com imunobiológicos na rinossinusite crônica
Authors: Sá Teixeira Pedro Henrique , Soares Itallo de Carvalho
Published: August 2023

Objetivo: analisar trabalhos científicos que abordem o tratamento da rinossinusite crônica utilizando imunobiológicos. Materiais e Métodos: trata-se de uma revisão integrativa da literatura, desenvolvida a partir da pergunta norteadora "Quais as atualizações no tratamento – utilizando imunobiológicos – da rinossinusite crônica?". Utilizou-se como banco de dados a Biblioteca Virtual de Saúde, com os descritores “sinusitis” AND “treatment” AND “eosinophils”, sendo encontrados 158 trabalhos. Além disso, utilizou-se o banco de dados do PUBMED, porém com descritores diferentes a fim de aumentar a amostragem de publicações. Os descritores foram “sinusitis” AND “rhinitis” AND “treatment” AND “immunotherapy”, encontrando-se 35 publicações. Resultados: apesar da escassez de publicações acerca dos imunobiológicos, dentre os estudos analisados, foi possível identificar os que abordavam de forma específica alguns dos imunobiológicos disponíveis para tratamento da rinossinusite crônica, como Omalizumabe, Dupilumabe, Benralizumabe e Reslizumabe. Conclusão: o horizonte para o tratamento da rinossinusite crônica utilizando os imunobiológicos mostra-se promissor, apesar da escassez de publicações científicas realizadas no Brasil, envolvendo uma amostragem maior e que comparem as terapias atuais – com corticoides e antibióticos – com a terapia imunológico.
Filistin’de Gizli Yahudi Örgütü Hashomer ve Faaliyetleri (1909-1918)
Authors: ALFARRA Abdelrahman
Published: August 2023

Osmanlı Devleti, Filistin’indeki hakimiyetini yitirme sebeplerinin başında, Siyonistlerin bölgede kurdukları gizli örtüler gelmektedir. Bunlar; karmaşık, gizli ve Filistin başta olmak üzere Osmanlı’nın toprak bütünlüğünü tehdit edecek niteliği taşıyan istihbari örgüt özelliğine sahiptiler. Hashomer da Filistin’de kurulan bu tür gizli Yahudi örgülerinden en önemlilerinden biridir. Tıpkı diğer Siyonist örgütler gibi bölgeyi kontrol altında tutmak amacıyla 1909 yılında Filistin’de kurulmuş olan silahlı oluşumlardan biridir. Çalışmada; 1909 yılından Birinci Dünya Savaşı’na uzanan süreçte bu örgütün kuruluşu ve yaptığı bazı faaliyetler ele alınmaktadır.
DeepQ Feature Selection and Recognition of Handwritten Prediction Using Convolutional Neural Networks
Authors: Sasi Kumar A. , Aithal P. S.
Published: August 2023

Purpose: Deep learning (DL) is referred to as the "hot subject" in pattern recognition and machine learning. The unmatched potential of deep learning allows for the resolution of the majority of complex machine learning issues, and it is evident that it will receive attention within the framework for mobile devices. There are tools for pattern recognition that can be used by smart applications of the next generation to make huge changes.
Design/Methodology/Approach: The deep feature convolutional network (DEEPQ-CNN) extracts the high representation and features of the hierarchical image from the relevant training data when data-driven learning is enabled. In addition, the DEEPQ-CNN characterization strategies are adapted to a couple of datasets in the boundaries and construction. The running time of the neural network and the network's weight are essential requirements for mobile computing.
Finding/Results: In the proposed system, the design of the image processing module is based on the characteristics of a mobile device's convolutional neural network. However, the use of mobile devices for data collection, processing, and construction is described. Last but not least, the computing conditions and mobile device data features are taken into account.
Original Value: For optical character recognition (OCR), specific datasets support the lightweight network structure. CNN is utilized to approve the proposed framework when examinations are made with the results of past methods to perceive the optical person.
Paper Type: Research
ABCD Analysis of Industries Using High-Performance Computing
Authors: P. A. Shajil Kumar , Rao Kunte R. Srinivasa
Published: August 2023

Purpose: High-Performance Computing (HPC) is the technique of increasing the overall processing capacity of the system, and achieving high performance in solving large problems in science, engineering, or business. This research paper investigated the High-Performance Computing industry using exploratory research methodology and a listing of ABCD analysis is done. Along with this, the identification of various applications and grand challenges in HPC and various Software Tools required for industry-specific application areas of HPC is done.
Design/Methodology/Approach: Qualitative exploratory research methodology to perform Industry Analysis of High-Performance Computing using ABCD Analysis. This research paper is written with the literature review of High-Performance Computing (HPC) industries and various software tools available to use in those industries.
Findings/Results: Finding of this research paper is the identification of various grand challenges in HPC industries like healthcare and medical field, engineering and design, aerospace sector, urban planning, and infrastructure, finance, and business. It also lists different HPC software tools that can be used to solve these challenges, along with the findings of ABCD analysis of HPC industry.
Originality/Value: Listing of ABCD Analysis (Advantages, Benefits, Constraints, and Disadvantages) of High-Performance Computing industry.
Paper Type: Industry Analysis research paper
Tapinella phuketensis n. sp. - a new species from Thailand (Insecta: Psocoptera)
Authors: Georgiev Dilian
Published: August 2023

A new species of Tapinella Enderlein, 1908 from Phuket Island, Thailand named Tapinella phuketensis n. sp. was described. It was found in a rain forest east of Karon Village at the west coast of the island. The species is unique in having blackish-brown wings with a white stripe in their middle part.
ESTUDO DA GOVERNANÇA DE TI EM UMA COOPERATIVA DE CRÉDITO
Authors: Bellini Daniela , Noveli Marcio
Published: August 2023

Esta pesquisa tem por objetivo analisar as características do framework de decisão e a identificação dos mecanismos de processo, estrutura e relacionamento, da Governança de Tecnologia de Informação (TI) de uma Cooperativa de Crédito. Realizou-se um estudo de campo com a intenção de identificar o caso particular da Sicoob Central em relação a sua estrutura de governança de TI, utilizando uma metodologia qualitativa, por meio de entrevistas semiestruturadas com membros da alta gestão e parte tática da organização. Realizou-se a caracterização do framework de decisão, considerando princípios de negócios, arquitetura de TI, infraestrutura de TI, necessidade de aplicações de negócio e investimentos em TI. De modo geral, o estudo lança luz sobre as práticas de governança do Sicoob Central e fornece insights sobre os processos decisórios, mecanismos estruturais e relacionamentos que sustentam a estrutura de governança de TI da organização. Essas descobertas podem ajudar outras organizações a desenvolver estratégias e estruturas eficazes de governança de TI que se alinhem com seus objetivos de negócios e melhorem seu desempenho geral.