bluuebunny/crossref_metadata_2025 huggingface dataset:
Intercalated Organic Redox-active Anions for Enhanced Capacity of Layered Double Hydroxides
Authors: Gerlach Patrick , Douard Camille , Gaalich Insaf , Athouël Laurence , Sarmet Julien , Leroux Fabrice , Tavoit-Gueho Christine , Stevens Philippe , Toussaint Gwenaëlle , Brousse Thierry
Published: June 2023

A Layered Double Hydroxide (LDH) compound LDH ([Mg2Al(OH)6]+ x 2 H2O) intercalated with a redox active organic anion, Anthraquinone-2-sulfonate (AQS), has been envisioned as an electrode material for high power aqueous based battery. The purpose is to use this interlayer redox active molecule for the enhancement of the specific capacity at the LDH composite electrode, which should allow fast charge transfer at the negative electrode for high power storage applications. This is achieved by the reduction of AQS in charge and oxidation in discharge within a redox inactive LDH matrix. The first charge of this new material [Mg2Al(OH)6]+[AQSO3]− x 2 H2O leads to a capacity of 100 mAh g−1 at − 0.78 V vs Ag/AgCl (based on the weight of the active material) when operated in aqueous 1 M sodium acetate electrolyte. However, low cycling stability was observed, since a drastic loss in specific capacity occurs after the first charge. This study focuses at elucidating the mechanism behind this phenomenon via in situ UV/vis experiments. Subsequently, the dissolution of charged AQS anions into the electrolyte during the first charge of the anode has been identified and quantified. Such understanding of fading mechanism might lead to the design of improved LDH-based electrodes, which utilize redox active anions working in the positive potential range with enhanced cycling ability.
Highly Sensitive and Selective Electrochemical Monitoring of Antibiotic Ciprofloxacin Using Electrochemically Exfoliated@reduced Graphene Oxide/Clay Graphite Electrode
Authors: Azriouil M , Chhaibi B. , Hrioua A. , Laghrib F. , Farahi A. , Bakasse M. , Lahrich S. , EL Mhammedi M. A.
Published: June 2023

This research work covers the development of a green, sensitive, selective, and simple electrochemical strategy for the detection of ciprofloxacin (Cipro) in biological fluids, wastewater, and drug samples. Herein the carbon paste electrode was modified using reduced graphene oxide and clay nanocomposite based on the electrochemical reduction of GO (ErGO-Clay@CPE). The electrochemical impedance spectroscopy (EIS) and cyclic voltammetry were used for the electro-characterization of ErGO-Clay@CPE, and the results supported that the ErGO-Clay improved the electrode’s conductivity and surface area. Moreover, the electrochemical performance was inspected by differential pulse voltammetry (DPV) and chronoamperometry in phosphate buffer (PB, pH = 6). The data demonstrated a magnificent sensitivity of ErGO-Clay@CPE regarding Cipro. Under the optimized operating conditions, the electro-analytical response was linearly related to the Cipro concentration in the range of 0.03–2.0–50.0 μM with a lower detection limit (DL = 3 × SDblank/P) and sensitivity of 2.24 nM and 96.28 μA μM−1 cm−2, respectively. Furthermore, the ErGO-Clay@CPE was applied to identify the Cipro in drugs, wastewater, and urine samples, with satisfied recoveries.
Ecofriendly Synthesis of Tenorite (CuO) Nanoparticles Composite with β-cyclodextrin as an Electrochemical Sensor for the Determination of the Anticancer Drug Phloretin
Authors: Korgaonkar Karuna , Pollet Bruno G. , Seetharamappa J. , Kalanur Shankara S.
Published: June 2023

The present study reports the eco-friendly synthesis of single-phase tenorite (CuO) nanoparticles using an aqueous extract of Plectranthus scutellarioides for the first time. These CuO nanoparticles were combined with β-cyclodextrin (β-CD) to form CuO@β-CD nanocomposite. The prepared CuO@β-CD nanocomposite was characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM) with energy dispersive X-ray (EDX), fourier-transform infrared (FT-IR), zeta potential and the particle size analyser techniques. The nanocomposite was further utilized to fabricate an electrochemical sensor for the electrochemical investigation of an anticancer drug, phloretin (PHL). PHL exhibited two irreversible oxidation peaks at 0.807 V and 1.126 V on CuO@β-CD/GCE in phosphate buffer solution of pH 3. A 9-fold increment in the oxidation peak current of PHL was seen at CuO@β-CD/GCE when compared to that at bare/GCE. The oxidation peak current was observed to vary linearly with the concentration of PHL in the range of 0.05–102.04 μM for square wave voltammetric (SWV) method. The values of limit of detection (LOD) and limit of quantification (LOQ) were calculated and found to be 0.012 and 0.041 μM, respectively. The low relative standard deviation (RSD) values for inter- and intra-day assays revealed the good reproducibility and stability of the proposed method.
Recurrent Hydatidiform Moles: A Clinical Challenge—A Case Report and an Update on Management and Therapeutical Strategies
Authors: Riccio S. , Galanti F. , Scudo M. , Di Troia L. , Ferrillo M. G. , Manzara F. , Ianiri P. , Battaglia F. A.
Published: June 2023

Hydatidiform mole, complete or partial (CHM/PHM), is the most common type of gestational trophoblastic disease (GTD), which is characterized by excessive trophoblastic proliferation and abnormal embryonic development. Some patients present with sporadic or familiar recurrent hydatidiform moles (RHMs), which are characterized by two or more episodes of the disease. A healthy 36-year-old woman was admitted to the Obstetrics and Gynecology Unit of Santa Maria Goretti Hospital, Latina, because of RHMs at 6 weeks of amenorrhea, with an obstetrical anamnesis of RHMs. We performed uterine dilatation and curettage with suction evacuation. The histological examination confirmed the diagnosis of PHM. The clinical follow-up was conducted according to recent guidelines on the diagnosis and management of GTD. After the return to the baseline values of the beta-human chorionic gonadotropin hormone, a combined oral contraceptive therapy was proposed, and the patient was invited to undergo in vitro fertilization (IVF) techniques, specifically oocyte donation, to reduce the possibility of similar future cases of RHMs. Although some etiopathogenetic mechanisms involved in RHMs are still unknown, all patients of childbearing age who are affected by this syndrome should be properly treated and directed towards a correct clinical path as IVF, to have a successful and safe pregnancy.
Wide E-Plane Beamwidth Microstrip Patch Antenna Using H-Shaped Gap-Coupling with Three Parasitic Patches for the K-Band
Authors: Park Jeong-Hun , Lee Moon-Que
Published: June 2023

This article presents a new wide E-plane beamwidth rectangular microstrip patch antenna adopting H-shaped gap-coupling with three parasitic patches for the K-band vehicle parking monitoring system, while keeping single substrate. Both side and upper parasitic elements serve as λ and λ/2 resonators and are excited primarily by magnetic and electric couplings, respectively. The synthesis of radiation patterns from main and auxiliary elements results in the E-plane wide-beamwidth property. The proposed gap-coupling antenna provided the peak gain of 4.82 dBi, E-plane half-power beamwidth (HPBW) of 143.4°, and co-to-cross-pol ratios of 22.7 and 20.2 dB within the HPBW for the E- and H-planes, respectively. The presented geometry showed excellent figure of merits compared with others for the K-band.
Influence of Initiation Modes in the Bundle-Series Initiation of a Large Number of Shock Tubes by Detonators
Authors: Choe Yong Chol , Han Un Chol , Kim Jong Min
Published: June 2023

The bundle-series initiation is currently used as the method for simultaneously transmitting blast signals from a detonator to a large number of shock tubes for blasting using shock tubes and its initiation modes affect the ability and probability of signal transmission. A numerical study of the influence of initiation modes on the pressure impulse generated by detonators and transmitted to a large number of shock tubes has been undertaken with ANSYS AUTODYN code and validated through experimental results of signal transmission probability of shock tubes. Numerical simulations and experiments used lateral and frontal bundle-series initiation modes for a large number of shock tubes. For a bundle of many shock tubes, peak pressures of pressure impulses affected within all shock tubes beside the first layer around a detonator, and signal transmission probabilities were higher for frontal bundle-series initiation mode than for lateral bundle-series initiation mode. The magnitude of a numerically obtained pressure impulse to a bundle of shock tubes shows a good correlation with the experimentally obtained signal transmission probability of shock tubes. Finally, the results are employed in the application of a frontal bundle-series initiation mode with the simultaneous bundle-series initiating a large number of shock tubes for blastings in mining and construction.
Splenic Lymphangioma Mimicking Lymphomatous Involvement: A Case Report with Review of the Literature
Authors: Soleimani Neda , Pouraminaee Fatemeh , Anbardar Mohammad Hossein , Bahador Ali , Rahimi Benyamin , Mohammadzadeh Sahand , Aghakhaninejad Fatemeh , Farahmand Mohammad , Hasani Mahsa
Published: June 2023

Lymphangioma is a benign malformation of lymphatic vessels usually found in the head and neck areas or axilla. They may involve visceral organs with a lower percentage. Splenic lymphangioma is a rare tumor. This disease is often seen in children but may be diagnosed incidentally in adults. Most patients are asymptomatic, but in large and multifocal lesions, the patient may have some nonspecific symptoms such as abdominal pain, abdominal distention, nausea, vomiting, and loss of appetite. Physical examination may show no specific findings or detect palpable masses. The preoperative diagnosis of splenic lymphangioma is challenging. Histopathological evaluation and sometimes immunohistochemistry tests can result in a definitive diagnosis. In this study, we present an 18-year-old man, with Burkitt’s lymphoma who underwent laparotomy and total splenectomy as a result of cystic lesions discovered accidentally during imaging with the final diagnosis of splenic lymphangioma after histopathological evaluation.
Supplementary Figure S3 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Supplementary Figure S3. Top 20 master regulators that were differentially expressed in Cas9-p15 control and MELK knockout (KO) MDA-NB-231 cells.
FIGURE 5 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

CARM1 KO sensitizes cells to saturated FA. Sensitivity of control and CARM1 KO A1847 cells to BSA conjugated palmitate FA determined by colony formation assay (A), which was quantified as dose–response curves (B). C–D, Same as A and B but not control and CARM1-overexpressing CAVO3 cells. E, Expression of cleaved PARP, cleaved Lamin A, CARM1 and a loading control β-actin in control and CARM1 KO A1847 cells treated with or without SCD1 inhibitor CAY10566 and supplemented with 1 mg/mL BSA conjugated oleic acid or BSA control. Data represent mean ± SEM, n = 4 biologically independent experiments.
FIGURE 4 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

CARM1 expression sensitizes cells to SCD1 inhibition. Sensitivity of control and CARM1 KO A1847 cells to SCD1 inhibitor CAY10566 determined by colony formation assay (A), which was quantified as dose response curves (B). Sensitivity of control and CARM1-overexpressing CAVO3 cells to SCD1 inhibitor CAY10566 determined by colony formation assay (C), which was quantified as dose–response curves (D). E, Sensitivity of the indicated ovarian cancer cell lines to SCD1 inhibitor CAY10566 determined by colony formation assay, which was quantified as dose–response curves. P value was calculated using a two-tailed Student t test. Data represent mean ± SEM, n = 4 biologically independent experiments.
FIGURE 5 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Differential gene expression profile, consolidated gene set enrichment, and network analyses. A, Differences in gene expression are shown in volcano plot format, where the X-axis denotes the log2-transformed fold-change and the Y-axis denotes the –log10-transformed P value. The log2 fold-change was calculated as Cas9-p15 control cell fold-change/MELK KO MDA-MB-231 cell fold-change, resulting in positive values for genes overexpressed in the WT condition and negative values for genes overexpressed in the KO condition. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. The 10 most differentially expressed genes by P value are labeled using their gene symbol. B, Differences in the hallmark enrichment pattern are shown in a modified volcano plot format, where the X-axis denotes the normalized enrichment score and the Y-axis denotes the –log10-transformed P value. The normalized enrichment score was calculated as Cas9-p15 control cell score/MELK KO MDA-MB-231 cell score, resulting in positive values for hallmarks enriched in the WT condition and negative values for hallmarks enriched in the KO condition, as indicated at the top of the plot. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. Significant hallmarks are labeled using their gene set name. C, Pathway enrichment profile of the MELK-centered PPI network. In the left part of the plot, significantly enriched pathways, listed along the Y-axis, are represented in dot plot format; the X-axis represents the –log10-transformed P value; and the size of the dots reflects the number of pathway genes contained in the network. To the right of the dot plot, overlaps between enriched pathways and three gene sets defined after analyzing the MELK-centered protein–protein interaction network are indicated in heat map format. The gene sets of interest are indicated in the X-axis underneath the heat map, where dark blue denotes the presence of pathway genes and light blue denotes the absence of pathway genes in these gene sets.
FIGURE 5 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Differential gene expression profile, consolidated gene set enrichment, and network analyses. A, Differences in gene expression are shown in volcano plot format, where the X-axis denotes the log2-transformed fold-change and the Y-axis denotes the –log10-transformed P value. The log2 fold-change was calculated as Cas9-p15 control cell fold-change/MELK KO MDA-MB-231 cell fold-change, resulting in positive values for genes overexpressed in the WT condition and negative values for genes overexpressed in the KO condition. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. The 10 most differentially expressed genes by P value are labeled using their gene symbol. B, Differences in the hallmark enrichment pattern are shown in a modified volcano plot format, where the X-axis denotes the normalized enrichment score and the Y-axis denotes the –log10-transformed P value. The normalized enrichment score was calculated as Cas9-p15 control cell score/MELK KO MDA-MB-231 cell score, resulting in positive values for hallmarks enriched in the WT condition and negative values for hallmarks enriched in the KO condition, as indicated at the top of the plot. The nominal P value threshold at 5% is indicated by a dashed blue horizontal line. Significant hallmarks are labeled using their gene set name. C, Pathway enrichment profile of the MELK-centered PPI network. In the left part of the plot, significantly enriched pathways, listed along the Y-axis, are represented in dot plot format; the X-axis represents the –log10-transformed P value; and the size of the dots reflects the number of pathway genes contained in the network. To the right of the dot plot, overlaps between enriched pathways and three gene sets defined after analyzing the MELK-centered protein–protein interaction network are indicated in heat map format. The gene sets of interest are indicated in the X-axis underneath the heat map, where dark blue denotes the presence of pathway genes and light blue denotes the absence of pathway genes in these gene sets.
FIGURE 2 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

CARM1 enhances SCD1 expression by recruiting XBP1s to their promoters independently of its enzymatic activity. A, ChIP-seq track of CARM1 and H3R17me2a in the SCD1 promoter. The arrow indicates the CARM1 and H3R17me2a peak in the promoter region of SCD1 gene. B, ChIP-qPCR analysis for the binding of CARM1 and H3r17me2a or negative control IgG at the SCD1 promoter in control and CARM1 KO A1847 cells. C, CUT&RUN track of XBP1s in the SCD1 promoter. The arrow indicates the XBP1s peak in the promoter region of SCD1 gene. D, ChIP-qPCR analysis for the binding of XBP1s or negative control IgG at the SCD1 promoter in control and CARM1 KO A1847 cells. P value was calculated using a two-tailed Student t test. Data represent mean ± SEM, n = 3 biologically independent experiments.
FIGURE 1 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

CARM1 regulates genes involved in FA metabolism. A, Expression of CARM1 and a loading control β-actin in control and CARM1 knockout (KO) A1847 cells determined by immunoblot. B, Scatter plot of KEGG pathway analysis for genes upregulated in wildtype compared with CARM1 KO A1847 cells (WT/KO >2, FDR < 0.05). Dot size represents gene number, color represents P value. P values were calculated by KEGG analysis. C, Volcano plot illustrating the protein expression detected by RPPA in wildtype or CARM1 KO A1847 cell lysates. Red dots and green dots indicate protein expression significantly upregulated in wildtype and knockout cells, respectively. SCD1, FASN, and ACC1 were highlighted in blue. P value was calculated using a two-tailed Student t test. D, Schematic of the MUFA synthesis pathway. E, mRNA expression of ACC1, FASN, and SCD1 in control and CARM1 KO A1847 cells determined by qRT-PCR analysis. P value was calculated using a two-tailed Student t test. F, Expression of SCD1, FASN, ACC1 and a loading control β-actin in control and CARM1 KO A1847 cells as determined by immunoblot. G, Expression of SCD1, FASN, ACC1 and a loading control β-actin in control and CARM1 overexpressed CAOV3 cells as determined by immunoblot. P value was calculated using a two-tailed Student t test. Data represent mean ± SEM, n = 3 biologically independent experiments.
The Role of Social Media in Breast Cancer Care and Survivorship: A Narrative Review
Authors: Aristokleous Iliana , Karakatsanis Andreas , Masannat Yazan A , Kastora Stavroula Lila
Published: June 2023

Background: Female breast cancer (BC) is the most diagnosed cancer and the leading cause of malignancy-related death worldwide. With the widespread utilisation of the Internet, social media has presented an invaluable yet underemployed tool in the context of BC medical information dissemination, support hub formation, and patient empowerment. Summary: In this narrative review, we explore the untapped potential of social media in this context, caveats, and future directions that may aid in formulating a new era of patient led, in addition to patient-centred care. Key Messages: Social media represents a powerful tool with significant potential to enable the seeking and sharing of BC-related information, and enhance patient education, communication, engagement, and empowerment. However, its use is associated with a number of limitations, including confidentiality and addiction issues, excessive and inaccurate information, and a possibility of jeopardising the patient-doctor relationship. Further research is needed to shed more light on this topic.
Clinical and Radiographic Evaluation of Short Locking-Taper Implants Supporting Single Crowns in the Posterior Region: A 12-Year Retrospective Study
Authors: Liao Yilin , Wu Xinyu , Zhao Yaoyu , Yan Qi , Shi Bin
Published: June 2023

Few studies have reported the outcomes of short implants with a follow-up time > 10 years. This retrospective study aimed to evaluate the long-term outcomes of short locking-taper implants supporting single crowns in the posterior region. Patients who received these supporting implants (≤ 8 mm) in the posterior region from 2008 to 2010 were included. The clinical and radiographic outcomes and patient satisfaction were recorded. A total of 18 patients with 34 implants were included. The cumulative survival rate was 91.4% and 83.3% at implant and patient levels, respectively. Tooth brushing habit and history of periodontitis were significantly associated with implant failure (P < .05). The median marginal bone loss (MBL) was 0.24 mm (IQR: 0.01 to 0.98 mm). Biologic and technical complications occurred in 14.7% and 17.8% of implants, respectively. The mean modified Sulcus Bleeding Index was 0.52 ± 0.63, and the mean peri-implant probing depth was 2.38 ± 0.79 mm. All patients were at least quite satisfied, with the majority of patients (88.9%) being fully satisfied with the treatment. Within the limitations of this study, the short locking-taper implants supporting single crowns in the posterior region achieved promising outcomes in the long-term follow-up.
Probing Depth and Peri-implant Health as Related to Buccal and Lingual Bone Thickness Around Dental Implants: An Experimental Study
Authors: Zhou Miao Xian , Salinas Thomas J , Gruwell Scott F
Published: June 2023

A retrospective chart review was conducted of CBCT images captured between November 2019 and April 2021 on patients who underwent dental implant placement and had a periodontal charting. The buccal and lingual bone thickness around the implants was measured as an average of three measurements taken from the buccal and lingual aspects of implants. Implants with peri-implantitis were placed in Group 1, and implants with peri-implant mucositis or good peri-implant health were placed in Group 2. Wilcoxon rank sum test was used to compare the differences between the bone thicknesses of the groups. In total, 93 CBCT radiographs were screened, and 15 CBCT images with both an implant and corresponding periodontal charting were analyzed. Of the 15 implants examined, 5 presented with peri-implantitis (33%), 1 with peri-implant mucositis, and 9 with good peri-implant health. Within the limitations of this study, buccal bone thickness averaging ≥ 1.10 mm or midlingual probing depths ≤ 3.4 mm correlates with a more favorable peri-implant response. Larger studies are needed to substantiate these findings.
Cardiac Magnetic Resonance Imaging Versus Invasive-Based Strategies in Patients With Chest Pain and Detectable to Mildly Elevated Serum Troponin: A Randomized Clinical Trial
Authors: Miller Chadwick D. , Mahler Simon A. , Snavely Anna C. , Raman Subha V. , Caterino Jeffrey M. , Clark Carol L. , Jones Alan E. , Hall Michael E. , Koehler Lauren E. , Lovato James F. , Hiestand Brian C. , Stopyra Jason P. , Park Carolyn J. , Vasu Sujethra , Kutcher Michael A. , Hundley W. Gregory
Published: June 2023

Background:

The optimal diagnostic strategy for patients with chest pain and detectable to mildly elevated serum troponin is not known. The objective was to compare clinical outcomes among an early decision for a noninvasive versus an invasive-based care pathway.

Methods:

The CMR-IMPACT trial (Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients with Acute Chest Pain and Detectable to Elevated Troponin) was conducted at 4 United States tertiary care hospitals from September 2013 to July 2018. A convenience sample of 312 participants with acute chest pain symptoms and a contemporary troponin between detectable and 1.0 ng/mL were randomized early in their care to 1 of 2 care pathways: invasive-based (n=156) or cardiac magnetic resonance (CMR)–based (n=156) with modification allowed as the patient condition evolved. The primary outcome was a composite including death, myocardial infarction, and cardiac-related hospital readmission or emergency visits.

Results:

Participants (N=312, mean age, 60.6 years, SD 11.3; 125 women [59.9%]), were followed over a median of 2.6 years (95% CI, 2.4–2.9). Early assigned testing was initiated in 102 out of 156 (65.3%) CMR-based and 110 out of 156 (70.5%) invasive-based participants. The primary outcome (CMR-based versus invasive-based) occurred in 59% versus 52% (hazard ratio, 1.17 [95% CI, 0.86–1.57]), acute coronary syndrome after discharge 23% versus 22% (hazard ratio, 1.07 [95% CI, 0.67–1.71]), and invasive angiography at any time 52% versus 74% (hazard ratio, 0.66 [95% CI, 0.49–0.87]). Among patients completing CMR imaging, 55 out of 95 (58%) were safely identified for discharge based on a negative CMR and did not have angiography or revascularization within 90 days. Therapeutic yield of angiography was higher in the CMR-based arm (52 interventions in 81 angiographies [64.2%] versus 46 interventions in 115 angiographies [40.0%] in the invasive-based arm [
P
=0.001]).

Conclusions:

Initial management with CMR or invasive-based care pathways resulted in no detectable difference in clinical and safety event rates. The CMR-based pathway facilitated safe discharge, enriched the therapeutic yield of angiography, and reduced invasive angiography utilization over long-term follow-up.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT01931852.
Impact of a Prior Cancer Diagnosis on Quality of Care and Survival Following Acute Myocardial Infarction: Retrospective Population-Based Cohort Study in England
Authors: Teece Lucy , Sweeting Michael J. , Hall Marlous , Coles Briana , Oliver-Williams Clare , Welch Cathy A. , de Belder Mark A. , Deanfield John , Weston Clive , Rutherford Mark J. , Paley Lizz , Kadam Umesh T. , Lambert Paul C. , Peake Michael D. , Gale Chris P. , Adlam David ,   on behalf of the VICORI Collaborative
Published: June 2023

Background:

An increasing proportion of patients with cancer experience acute myocardial infarction (AMI). We investigated differences in quality of AMI care and survival between patients with and without previous cancer diagnoses.

Methods:

A retrospective cohort study using Virtual Cardio-Oncology Research Initiative data. Patients aged 40+ years hospitalized in England with AMI between January 2010 and March 2018 were assessed, ascertaining previous cancers diagnosed within 15 years. Multivariable regression was used to assess effects of cancer diagnosis, time, stage, and site on international quality indicators and mortality.

Results:

Of 512 388 patients with AMI (mean age, 69.3 years; 33.5% women), 42 187 (8.2%) had previous cancers. Patients with cancer had significantly lower use of ACE (angiotensin-converting enzyme) inhibitors/angiotensin receptor blockers (mean percentage point decrease [mppd], 2.6% [95% CI, 1.8–3.4]) and lower overall composite care (mppd, 1.2% [95% CI, 0.9–1.6]). Poorer quality indicator attainment was observed in patients with cancer diagnosed in the last year (mppd, 1.4% [95% CI, 1.8–1.0]), with later stage disease (mppd, 2.5% [95% CI, 3.3–1.4]), and with lung cancer (mppd, 2.2% [95% CI, 3.0–1.3]). Twelve-month all-cause survival was 90.5% in noncancer controls and 86.3% in adjusted counterfactual controls. Differences in post-AMI survival were driven by cancer-related deaths. Modeling improving quality indicator attainment to noncancer patient levels showed modest 12-month survival benefits (lung cancer, 0.6%; other cancers, 0.3%).

Conclusions:

Measures of quality of AMI care are poorer in patients with cancer, with lower use of secondary prevention medications. Findings are primarily driven by differences in age and comorbidities between cancer and noncancer populations and attenuated after adjustment. The largest impact was observed in recent cancer diagnoses (<1 year) and lung cancer. Further investigation will determine whether differences reflect appropriate management according to cancer prognosis or whether opportunities to improve AMI outcomes in patients with cancer exist.
Regional Inequalities in Nineteenth-Century Female Wages: Evidence from Belgium
Authors: Buyst Erik , Delabastita Vincent
Published: June 2023

Although recent studies on the geography of the female labor force have highlighted strong spatial variation in women’s labor market participation, little is known about regional female wage inequalities in nineteenth-century industries. An analysis of female regional wage inequality for late-nineteenth-century Belgium, a country known for its early industrialization, finds a positive correlation between female industrial employment and wage levels, underlining the importance of industrial labor demand in shaping the female labor market experience. This finding is augmented by a correlational analysis of various market drivers.
A History of Double Criminality in Extradition
Authors: Boister Neil
Published: June 2023

This article sets out the history of double criminality in the law of extradition. It shows how that it only emerged as a legal requirement in the ‘Jay Treaty’, the 1794 treaty between theUSand UK. The article explores how the ‘Jay proviso’, a procedural requirement that the requesting state produce sufficient evidence to satisfy the requested state of the criminality of the requested person, morphed through interaction between common law and civil law states into a substantive requirement that the acts for which extradition is requested be criminal under the laws of both states. The article diccusses the evolution of the idea, and of its rationale, and then concludes that acceptance of this idea by the early part of the 20th Century confirmed its status as a general principle of law, or perhaps even a rule of customary international law.
Zur Bedeutung und Rolle von „Wirklichkeit“ und „Wahrheit“ in mittelalterlicher Literatur, mit einem besonderen Blick auf Der guote Gêrhart des Rudolf von Ems
Authors: Eberhardt Otto
Published: June 2023

Middle High German has no equivalent to our word “reality”. Instead the terms “wâr”, “wære”/“gewære”, and “wârheit” applied primarily. They could denote two things: either the higher reality in the divine realm, or simply everyday reality. Both are encountered in Der guote Gêrhart by Rudolf von Ems.
Zur Notwendigkeit eines textsortendifferenzierten Herangehens an mittelalterliche Stadtbücher
Authors: Smereka Joanna
Published: June 2023

This article connects the existing results of the study of the language of the medieval city chancellery of Cracow, which was conducted without distinguishing individual entries into the text types they represent, with the results of the analysis of the language in testamentary records. Wills, as a type of text, appear in city records as a mass source. It seems that the previous claim as to an almost unconditional avoidance of dialectal features in the city registry must undergo some reconsideration depending not only on the producer of the text, but also the entire context of the communicative situation and the type of text that is the written product of a social activity. The analy-sis not only verifies previous assertions, but also draws attention to a new research perspective on medieval city books, which is worth applying to the selection of the research corpus. The author also refers to her earlier contributions in the field of the syntactic research on the medieval city chancellery.
Establishing the true identity of Passiflora nephrodes (Passifloraceae), resulting in Passiflora rosacea, a new species from Santa Cruz, Bolivia
Authors: KUETHE J.R. , JUSTINIANO HERMES
Published: June 2023

The identity of Passiflora nephrodes, a species of Passiflora subg. Passiflora ser. Menispermifoliae, has been re-evaluated and the true species is here illustrated. This name has been long associated to cultivated material widely found in Europe, however recent collections made in Bolivia revealed that this name does not correspond to P. nephrodes as to type. Recent collections in Bolivia have shown that this plant does not correspond with the original source material for P. nephrodes. Endemic accessions, both from field collections and herbarium specimens of true P. nephrodes and plants commonly found in cultivation under this name have been closely examined and compared to the original literature and their respective type-materials. The cultivated plant, now found to be originating from the department of Santa Cruz, Bolivia, relates to a new species which is here described as Passiflora rosacea. New populations of true P. nephrodes have been found in the department of La Paz, Bolivia, and the original description for this species has been further improved based on those recent collections. The taxonomy, ecology, and conservation for both species is discussed.
Lectotypifications in Imperata (Poaceae: Panicoideae: Andropogoneae)
Authors: PINTO BIANCA LETICIA DE SOUZA , PRADO JEFFERSON , MARZINEK JULIANA , WELKER CASSIANO A. DORNELES
Published: June 2023

Imperata is a cosmopolitan grass genus with species well distributed across the American continent. During taxonomic studies of the genus, we observed problems in the typification of five names of Imperata species from the New World: I. arundinacea var. americana, I. brasiliensis, I. brasiliensis var. mexicana, I. brevifolia, and I. minutiflora. In this paper, we designate lectotypes for these names and present images of the chosen lectotypes.
Philodendron josephii (Araceae), a new species from central Amazonia, Brazil
Authors: BATISTA CAIO AUGUSTO DOS SANTOS , SOARES MARIA DE LOURDES DA COSTA
Published: June 2023

Philodendron josephii sp. nov. is described from terra firme tropical humid forest in Amazonas state, Brazil. This new species is similar in its leaf morphology to two other Amazonian species, P. maximum and P. megalophyllum, but differs by characters of the prophyll, petiole, flagelliform branches and ovary. The description is accompanied by illustrations, notes on the habitat, geographic distribution and conservation status.
Taxonomic review of the Andean crab spiders genus Coenypha Simon, 1895 (Thomisidae: Stephanopinae)
Authors: MACHADO MIGUEL , PREVIATO THALES , GRISMADO CRISTIAN J. , TEIXEIRA RENATO
Published: June 2023

The genus Coenypha Simon, 1895 is composed of species distributed on the Southern Andean Region and Patagonia, and presents remarkable somatic morphologies, such as the flattened habitus, enlarged femora I, and a wide opisthosoma. Molecular and morphology-based phylogenies have revealed the close relationship of this genus with sympatric species previously assigned to Stephanopis O. Pickard-Cambridge, 1869. Our recent cladistic analysis extended such preliminary results in recovering numerous morphological characters as synapomorphies of a well-supported clade, thus justifying the transfer of all species of ‘Andean Stephanopis’ to Coenypha. In the present work, we provide a taxonomic review of these species, update their diagnoses, descriptions and illustrate them through detailed photographs. New distribution records are presented, the male of C. antennata (Tullgren, 1902) is described for the first time, and two new species are described based on both sexes (Coenypha trapezium sp. nov. and Coenypha foliacea sp. nov.). Stephanopis exigua (Nicolet, 1849) is considered a nomen dubium. Stephanopis verrucosa (Nicolet, 1849), Thomisus spectrum Nicolet, 1849, and T. pubescens Nicolet, 1849 are synonymized with Coenypha nodosa (Nicolet, 1849). The synonymy of Thomisus nicoleti Roewer, 1951 (a replaced name for T. cinereus Nicolet, 1849 due to a homonymy) with Misumenops temibilis (Holmberg, 1876) is rejected, and considered together with Stephanopis spissa (Nicolet, 1849), Thomisus variabilis Nicolet, 1849 and Stephanopis maulliniana Mello-Leitão, 1951, synonyms of Coenypha ditissima (Nicolet, 1849); Stephanopis badia Keyserling, 1880 is transferred to Sidymella Strand, 1942.
Automatic Detection of Increased Signal Intensity from T2-Weighted Magnetic Resonance Images (MRIs) of Cervical Vertebra
Authors: Guan Yunzhi , Yang Shuo , Sun Chi , Zhang Yuxuan , Xu Guangyu , Wang Hongli , Zhang Yiman , Lu Weining , Jiang Jianyuan
Published: June 2023

Automatic detection of increased signal intensity (ISI) in spinal cord from T2-weighted magnetic resonance images (MRIs) of the cervical vertebra was design. To diagnose the conditions of spinal cord automatically and aid doctors in treating patients with cervical degenerative diseases.
724 MR T2 images were annotated by two doctors with ISI information and 245 MR T2 ones with the mask of cervical discs and spinal cord. The proposed approach contains three modules: (1) a module named region proposal to generate the ISI proposals. This module is based on three submodules:
(a) a Mask R-CNN model to segment the cervical disc and spinal cord, (b) a rule-based algorithm for verifying the segmentation result, (c) an algorithm for getting the segment of spinal cord according to the verified segmentation result; (2) a feature extraction method based on Laplace operator
to extract the feature of segments of spinal cord; (3) a classifier based on Linear Discriminant Analysis to classify the segments of spinal cord. Our ISI detection method achieved 31.9 AP in the test. And while using Fβ score (β = 1.3) the method got 85.4% recall
and 2.16 FP per image. In this study, we proposed an approach based on Mask R-CNN to detect ISI on MR T2 images automatically and achieved good performance both in accuracy and speed.
Rapid Detection of Human Adenovirus by Loop-Mediated Isothermal Amplification of Nucleic Acids Extracted Using Magnetic Nanoparticle Enrichment Technology
Authors: Hu Guohong , Ma Xinye , Zhang Xinyu , Wu Zhihui , Wu Yanqi , Chu Zhou , Chen Hui
Published: June 2023

The human adenovirus (HAdV) genotypes HAdV-3 and HAdV-7 are currently the most prevalent variants in China and are responsible for frequent mass outbreaks. Early diagnosis is crucial for infection control and timely treatment. Here we established an assay using loop-mediated isothermal
amplification (LAMP) for rapid detection of nucleic acids extracted using magnetic nanoparticle enrichment technology to detect these two HAdV genotypes. The LAMP assay results were 100% consistent with those obtained using quantitative polymerase chain reaction, and the turnaround time was
shorter, enabling earlier detection, diagnosis, and treatment of patients.
Enhanced In Vitro Cytotoxicity and In Vivo Nursing Care of Gastric Cancer Cells by Nanoparticles Bearing Platinum (IV) Prodrug of Cisplatin
Authors: Zhao Xiaoqian , Zhang Guoshan , Ke Jianlin , Wang Jianguo , Zhuo Hongqing
Published: June 2023

Gastric cancer is known as the fourth most common cancer and the second main cause of cancer-related deaths. Finding a suitable system of drug delivery for effective treatment in gastric cancer chemotherapy has been of great value in recent years. Platinum-based drugs are among the
most popular drugs for solid tumors chemotherapeutic agents in the clinic. However, severe side effects such as neurotoxicity and etc. It limits the use of extreme doses of the drug. To overcome these issues Pt(IV) prodrugs and nanocarriers as the platinum delivery systems might represent
the next generation of platinum-based drugs. The present assay aimed to develop a nanoparticles-based Pt(IV) prodrug delivery system to enhance the In Vitro cytotoxicity and In Vivo nursing care of gastric cancer. The characterizations depicted that the synthesized formulation
exhibited beneficial physicochemical properties. The biological assays showed that the synthesized formulation exhibited a sustained drug release profile. Moreover, the application of the synthesized formulation enhanced the In Vitro cytotoxicity and In Vivo nursing care of gastric
cancer. The results suggest that the developed formulation is one of the most important candidates for nursing care is to treat this kind of diseases.
A Systematic Evaluation of Imaging Diagnostic Morphology of Gastric Submucosal Tumors
Authors: Yu Libo , Feng Peipei , Li Lei
Published: June 2023

Systematic evaluation of the diagnostic morphological features of submucosal tumors (SMTs) in the stomach. The Chinese and English-related clinical research literature published in Chinese and English databases (including PubMed, SinoMed, EMBASE, CNKI, Wanfang, VIP, etc.) from January
2000 to November 2022 were searched. Two researchers independently completed literature screening, content extraction, literature quality assessment, and RCT bias risk, and a meta-analysis was performed using Review Manager 5.3 software in Cochrane. A total of 8 literatures were included,
including 1175 patients with SMTs, including 597 GIST, 274 leiomyomas, 2 granulosa cell tumors, 143 ectopic pancreases, 31 cysts, 9 schwannomas, 66 lipoma, and 53 others. Four English and four Chinese literatures were included, and three of the selective results were reported as high risk.
The results of the meta-analysis showed significant differences in the shape characteristics, tumor size, echo characteristics, and origin level characteristics of SMTs patients with different diseases (P <0.05). However, imaging diagnostic efficacy was higher, and there was little
difference in imaging diagnostic efficacy among SMTs patients with other conditions (P >0.05). Current evidence indicates that imaging techniques have high diagnostic efficiency in the identification and diagnosis of SMTs diseases, and morphological heterogeneity is present in different
conditions.
Keratinized Odontogenic Cysts in a Malayan Tiger (Panthera tigris jacksoni)
Authors: Jeffrey Alison , Artzer Marjory , Gardhouse Sara , Sarvi Jasmine , McHaney Anastasia , Bell Cindy , Winter Douglas
Published: June 2023

A 14-year-old male intact Malayan tiger ( Panthera tigris jacksoni) was presented for a routine annual wellness exam and comprehensive oral health assessment and treatment, during which an odontogenic cyst was incidentally diagnosed from radiographs. Prior to a second immobilization for computed tomography (CT) and surgical removal of the cyst, the tiger developed anorexia, lethargy, and reluctance to train, which were clinical signs suspected to be reflective of pain secondary to the odontogenic cyst. A CT scan of the skull revealed 2 odontogenic cyst lesions associated with teeth 204-207 and 208-209, and associated tooth root resorption, focal lysis of the maxilla, communication with the left nasal passage, thinning of the ventral margin of the left orbit and maxillary foramen, and left mandibular lymphadenopathy. Complete enucleation of each cyst wall and surgical extraction of associated teeth were performed. Histopathologic findings were consistent with an odontogenic cyst containing keratinized stratified squamous epithelium, keratin debris within the cyst lumen, and a lymphoplasmacytic inflammatory infiltrate. Postoperatively, the tiger recovered uneventfully, clinical signs resolved within 2 weeks and have not recurred at the time of publication of this article. Similar keratinized odontogenic cysts are described in dogs, and there is only one other case report in a felid. This is the first known report of an odontogenic cyst in a tiger and of a keratinized odontogenic cyst in a nondomestic species.
Hypertension and traditional risk factors for cardiovascular diseases among treatment naïve HIV- infected adults initiating antiretroviral therapy in Urban Tanzania
Authors: Mwakyandile Tosi M. , Shayo Grace A. , Sasi Philip G. , Mugusi Ferdinand M. , Barabona Godfrey , Ueno Takamasa , Lyamuya Eligius F.
Published: June 2023

Background

Cardiovascular diseases (CVDs) have become an important cause of ill health and death among people living with HIV and/or AIDS (PLHIV) in the antiretroviral therapy (ART) era. There is scarce data on the burden of hypertension (HTN) and risk factors for CVDs among PLHIV in developing countries, including Tanzania during the ART era.

Objective(s)

To determine the prevalence of HTN and risk factors for CVDs among ART naïve PLHIV initiating ART.

Methods

We analysed baseline data of 430 clinical trial participants on the effect of low-dose aspirin on HIV disease progression among HIV-infected individuals initiating ART. HTN was the outcome CVD. Traditional risk factors for CVDs studied were age, alcohol consumption, cigarette smoking, individual and family history of CVDs, diabetes mellitus (DM), obesity/overweight, and dyslipidaemia. A generalized linear model (robust Poisson regression) was used to determine the predictors for HTN.

Results

The median (IQR) age was 37 (28, 45) years. Females were the majority contributing 64.9% of all participants. The prevalence of HTN was 24.8%. The most prevalent risk factors for CVDs were dyslipidaemia (88.3%), alcohol consumption (49.3%), and overweight or obesity (29.1%). Being overweight or obese predicted the occurrence of HTN, aPR 1.60 (95% CI 1.16–2.21) while WHO HIV clinical stage 3 was protective against HTN, aPR 0.42(95% CI 0.18–0.97).

Conclusion

The prevalence of HTN and traditional risk factors for CVDs in the treatment naïve PLHIV initiating ART are significant. Identifying these risk factors and managing them at the time of ART initiation may lower future CVDs among PLHIV.