bluuebunny/crossref_metadata_2025 huggingface dataset:
The Antibacterial Activity Comparison between Novel Carbon-Based Nanofilm Coated Titanium Alloy and Co-Cr-Mo Alloy
Authors: Ma Tianying , Ran Tianfei , Ke Song , Qin Yinyin , Wang Min
Published: August 2022

Objective. The purpose of this study was to reveal the antibacterial activity of carbon-based nanofilm titanium alloy. Methods. The experiments were performed both in vitro and in vivo of animals using two circular-piece test specimens of the same specification, which were made from carbon-based nanofilm coated titanium alloy and commonly used in artificial joints Co-Cr-Mo alloy, respectively. In the in vitro experiments, the two test specimens were cocultured with standard strains of Staphylococcus aureus and Escherichia coli, and the antibacterial properties of the two test specimens were evaluated via inhibition zone size, scanning electron microscopy, fluorescence staining, colony forming unit count, and others; the cytotoxicities of the two test specimens were evaluated by coculturing and them with rabbit bone marrow mesenchymal stem cells (BMSCs). In the in vivo experiments, the two test specimens were implanted in the muscle tissue of experimental rabbits to evaluate their histocompatibilities. Results. Both in vitro cocultures of the carbon-based nanofilm titanium alloy and the Co-Cr-Mo alloy with Staphylococcus aureus and Escherichia coli failed to form inhibition zone. However, some biofilms were observed on the surface of the Co-Cr-Mo alloy. Fewer bacteria adhered to the carbon-based nanofilm titanium alloy can be observed via scanning electron microscopy and fluorescence staining techniques. Meanwhile, the colony forming counts showed that, compared with the Co-Cr-Mo alloy, the carbon-based nanofilm titanium alloy had fewer bacteria adhered (

P
<
0.05

). After coculture of the two test specimens with rabbit BMSCs, there was no significant difference in cell count, and both cell counts showed no cytotoxicity. In the in vivo experiment of animals, there are relatively fewer giant cells and better histocompatibility in tissues near the carbon-based nanofilm titanium alloy. Conclusion. Compared with Co-Cr-Mo alloy, the novel carbon-based nanofilm titanium alloy enjoys stronger in vitro antibacterial activity and better in vivo histocompatibility.
Effects of Changyu Daotan Decoction on Depression via Restoration of Mice Hippocampus and Alteration of Expression of Relevant Neurotrophic Factors
Authors: Zhang Suifeng , Chen Qian , Wu Lirong , Sun Ke , Lan Xiaofang , Xie Xin , Yan Junfeng
Published: August 2022

Depression, a sort of common psychological disorder, is a serious hazard to people’s health and social progress. Conventional clinical means for this disorder nowadays are mostly chemical medicine treatments accompanied by psychological counseling. Chinese application of using TCM to treat mental diseases like depression could be traced from hundreds of years ago, in comparison to the long-term depression course and the chemical medicine administration demerits like side effects and resistance, traditional Chinese medicines are milder, more lasting, stable and are the optimal choice for perennial depression treatment. This study was committed to making a comprehensive investigation of Changyu Daotan Decoction’s efficacy in the depression mice model, and it turned out that the Changyu Daotan Decoction was capable of restoring the hippocampus of the depression mice and altering the expressions of neurotrophic factors (the expressions of β-Catenin, cyclin D1 and in GSK-3β BDNF, GFAP, NGF, and Wnt signaling pathways). Results of metabonomics analysis showed that the contents of GABA, His, Tyr, Trp, PA, and 5-HIAA in the mice of the Changyu Daotan Decoction group were restored after administration and showed a conspicuous relevance with the metabolic.
Caffeic Acid Phenethyl Ester Inhibits Basal Lipolysis by Activating PPAR-Gamma and Increasing Lipid Droplet-Associated Perilipin in Mature Rat Adipocytes
Authors: Trang Nguyen Thi Thu , Chiu Wan-Chun , Feng Yu-Ting , Hsieh Shu-Lin , Tung Do Dinh , Chang Jungshan , Fong Tsorng-Harn
Published: August 2022

Abnormal lipolysis is correlated with metabolic syndrome. Caffeic acid phenethyl ester (CAPE), a natural product from honeybee hives, has been reported to improve metabolic syndrome. However, the effects of CAPE on lipolysis and perilipin-1 (the major lipid droplet-associated protein) in mature adipocytes were not clarified. In this study, mature adipocytes were isolated from the epididymal fat pads of male rats and incubated with CAPE to estimate lipolysis by measuring glycerol release. It was found that the basal lipolysis was inhibited by CAPE in a dose- and time-dependent manner. The lipid droplet-associated perilipin-1 and phosphorylated peroxisome proliferator-activated receptor (PPAR) gamma levels increased following CAPE treatment by Western blot analysis. Moreover, a specific PPAR-gamma inhibitor (T0070907) could partly reverse the effect of CAPE on basal lipolysis. Furthermore, treatment of adipocytes with dibutyryl-cAMP (db-cAMP) or isoproterenol (ISO) increased lipolysis, but the drug-induced lipolysis was abrogated by combination treatment with CAPE. The lipid droplet-associated perilipin-1 level was also decreased in the drug-induced groups but increased when combined treatment with CAPE. In conclusion, our results revealed that a decrease in basal lipolysis and an increase in lipid droplet-associated perilipin-1 levels induced by CAPE may be involved in the regulation of lipid metabolism through activation of PPAR-gamma in mature adipocytes.
Epigenetic Alterations under Oxidative Stress in Stem Cells
Authors: Huang Min , Wu Qiang , Jiang Zhi-Hong
Published: August 2022

Epigenetic regulation of gene expression, including DNA methylation and histone modifications, provides finely tuned responses for cells that undergo cellular environment changes. Abundant evidences have demonstrated the detrimental role of oxidative stress in various human pathogenesis since oxidative stress results from the imbalance between reactive oxygen species (ROS) accumulation and antioxidant defense system. Stem cells can self-renew themselves and meanwhile have the potential to differentiate into many other cell types. As some studies have described the effects of oxidative stress on homeostasis and cell fate decision of stem cells, epigenetic alterations have emerged crucial for mediating the stem cell behaviours under oxidative stress. Here, we review recent findings on the oxidative effects on DNA and histone modifications in stem cells. We propose that epigenetic alterations and oxidative stress may influence each other in stem cells.
[Retracted] Analysis of the Impact of the Development Level of Aerobics Movement on the Public Health of the Whole Population Based on Artificial Intelligence Technology
Authors: Ji Weiping , Qiu Xuan
Published: August 2022

With the enhancement of China’s comprehensive national power and the improvement of people’s living standards, health has become the goal that people pursue. While people are thirsty for extensive knowledge and a healthy body, they also pay more attention to the cultivation of elegant temperament and the enjoyment of beauty, and aerobics has become a hot spot for national fitness with its advantages of coordinated and beautiful movements, bright and cheerful rhythm and obvious fitness effects. Aerobics is a new popular fitness sports, from the beginning of development by most fitness enthusiasts, especially it is a women’s favorite. To this end, the characteristics, value, status, and role of aerobics in the public health of all people are discussed, and the problems of poor recognition effect in the existing aerobics difficulty aerobics action recognition methods are proposed to apply the graph convolutional neural network to the aerobics difficulty aerobics action recognition. The video of aerobics is divided into several images, and the background of the aerobics difficult aerobics action image is eliminated, and the gray scale co‐generation matrix is set to estimate the local area blur kernel of the difficult action image to correct the visual error of the difficult action image. “change to” The aerobics action is divided into several difficult action images, and the gray‐scale symbiosis matrix is set to estimate the local area fuzzy core of the difficult action image, and correct the visual error of the difficult action image. On this basis, the graph convolutional neural network is pre‐trained to construct a human‐directed spatial‐temporal skeleton map, and the human‐directed spatial‐temporal map representation is modeled with temporal dynamic information to achieve aerobics difficult aerobics action recognition. The experimental results show that the recognition time of the difficult aerobics movements based on the graph convolutional neural network is shorter and the number of false recognitions is less in complex and simple backgrounds, which proves that the proposed method improves the recognition of difficult aerobics movements to achieve the goal of promoting the development level of aerobics and improving the public health of all people.
Globularia alypum Extracts Attenuate Hyperglycemia and Protect against Various Organ Toxicities in Alloxan-Induced Experimental Diabetic Rats
Authors: Tiss Mohamed , Hamden Khaled
Published: August 2022

In this study, we attempted for the first time to determine the phytochemical compositions and biopharmaceutical properties of Globularia alypum methanol extract (GAME) and Globularia alypum water extract (GAWE). High-performance liquid chromatography with diode array detection (HPLC-DAD) analysis was performed to establish the chemical profile of the investigated extracts. Chemical composition analysis was taken in the presence of various bioactive compounds such as quercetin 7-O-glucoside and apigenin 7-O-glucoside in GAME. In GAWE, various abundant compounds were found in the extract such as quercetin 7-O-glucoside, apigenin, quercetin, apigenin 7-O-glucoside, and cinnamic acid. This study showed that the administration of GAWE and GAME to type 1 diabetic rats decreased fasting blood glucose, protected pancreas β-cells from death and injury, increased liver glycogen rate, and ameliorated oral glucose tolerance test. Moreover, GA reduced weight loss, and diabetes decreased basic physical activity. In addition, the administration of GA extracts in diabetic rats protected from diabetes-induced liver, kidney, testes, heart, and bone toxicities. Conclusion. GAWE has possible value for antidiabetic oral medication.
Kartogenin Induced Adipose-Derived Stem Cell Exosomes Enhance the Chondrogenic Differentiation Ability of Adipose-Derived Stem Cells
Authors: Xie Aiguo , Xue Jixin , Wang Yuting , Yang Chao , Xu Miao , Jiang Yongkang
Published: August 2022

Objective. The objective of this study is to explore the effect of kartogenin (KGN-)-pretreated adipose-derived stem cell-derived exosomes (ADSC-EXOs) on the chondrogenic differentiation ability of ADSCs. Methods. Adipose-derived stem cells (ADSCs) were treated with different doses of KGN, and exosomes (EXOs) were extracted. EXOs were then identified using an electron microscope (EM), nanoparticle tracking analyzer, nanoparticle tracking analysis software, and exosomal protein markers. EXOs were labeled with the fluorescent dye PKH67 and their uptake by cells was evaluated. A cell counting kit-8 (CCK-8) assay, flow cytometry, clonogenic assay, and a cell scratch assay were used to detect the abilities of proliferation, apoptosis, clone formation, and migration of ADSCs, respectively. Subsequently, Alcian blue staining and toluidine blue staining were used to detect the chondrogenic differentiation ability of ADSCs in each group. Quantitative real-time polymerase chain reaction (qRT-PCR) and Western blot (WB) techniques were used to detect the expression of chondrogenic differentiation-related genes. Results. In this study, ADSCs and KGN-induced ADSC-EXOs were successfully extracted and isolated. EXOs and ADSCs coculturing results showed that KGN-induced ADSC-EXOs can significantly promote proliferation, clone formation, migration, and chondrogenic differentiation of ADSCs and inhibit apoptosis. In addition, KGN-induced ADSC-EXOs can increase the expression of chondrogenic-related genes in ADSCs (Aggrecan, Collagen III, Collagen II, and SOX9), and can significantly decrease the expression of chondrolysis-related genes (MMP-3, ADAMTS4, and ADAMTS5). Conclusion. KGN-induced ADSC-EXOs can enhance the chondrogenic differentiation ability of ADSCs by promoting cell proliferation and migration while inhibiting cell apoptosis. KGN treatment can also increase the expression of chondrogenic differentiation-related genes and decrease the expression of chondrolysis-related genes. These results provide a new approach to cartilage repair and regeneration.
Human-Wild Animals Conflict in and around Amba Forest, Ezha District, Gurage Zone, Southern Ethiopia
Authors: Sime Demelash , Siraj Zemedkun , Teklemariam Ashenafi , Tilahun Belete
Published: August 2022

The conflicts between humans and wild animals with the same resources are common but seldom reported in Ethiopia. This study was carried out to assess the causes, impacts, and mitigation strategies of the local communities with human-wild animal conflict (HWC) in and around Amba forest of Ezha District, Gurage Zone, Ethiopia: implications for wildlife conservation. Cross-sectional study design was applied, and data were collected from November 2019 to July 2020 through a semistructured questionnaire, focus group discussion (FGD), and field observation. A total of 53 respondents were randomly selected. The data were analyzed using SPSS software, and the results were presented using tables, graphs, charts, and text. The study result revealed that human-wild animal conflict exists, and it was seriously occurring at various places, time, and seasons. Papio anubis, Potamochoerus larvatus, Cercopithecus aethiops, Hystrix cristata, and Crocuta crocuta were the main conflicting wild animals, respectively. Abundance of wild animals, presence of forest, crop raiding, expansion of agriculture, and livestock predation were the main causes of conflict in the study area. There was a statistically significant relation between conflict and the cause of conflict (χ2(5) = 17.075,

p
=
0.004

). Psychological and economic impacts were the main impacts encountered. Most of the respondents (86.8%) had applied conflict mitigation strategies, but it was ineffective, although the trend of conflict was increasing. Many of the respondents (41.5%) had a negative attitude toward wild animals, but 58.5% encouraged wild animals’ conservation. HWC had increasing trends of conflict, and thus, a negative attitude was developed by the communities on wild animal coexistence and conservation. Therefore, awareness creation, training, and promoting coexistence mechanisms between humans and wild animals are necessary in the study area.
Study on Seismic Response Characteristics of Shield Tunnel in Soil‐Rock Combination Stratum
Authors: Shao Guang-Biao , Fan Xi-Sen , Shang Jin-Hua , Lu Li-Xin
Published: August 2022

The sharp change of stiffness in the soil‐rock combination stratum is the weak point in the seismic design of the tunnel structure. To explore the influence of soil‐rock combination stratum vibration on the shield tunnel, the section of Jinan rail transit line 4 at the Olympic Sports Center is used as the research background. Firstly, the two‐dimensional numerical model is established, and the internal force calculation and distribution law of the structure are studied. Then, based on the third similarity theory, the model similarity physical relationship is derived. The shaking‐table model test of the soil‐rock‐structure system is carried out. The seismic response law of tunnel cross‐section is studied by the model test and numerical analysis. The results revealed the following: (1) the peak bending moment distribution diagram derived from numerical calculation is consistent with that obtained from the shaking‐table model test, which has shown that the numerical and experimental methods are correct, and the research results are available for the seismic resistance of shield tunnels. (2) The deformation, axial force, shear force, and bending moment of the tunnel structure in the soil‐rock combination stratum under the action of S‐wave change abruptly and significantly at the soil‐rock interface section, and the difference in structural stress between the upper and lower sides of the soil‐rock interface increased by 65.5%. The excessive stress difference changes the damage mode of the tunnel. (3) The relative difference and abrupt change of bending moment and shear force at the interface is more significant than the axial force, so that the tunnel structure at the soil‐rock interface is most prone to bending‐shear damage.
[Retracted] Endophytic Fungi and Secondary Metabolites of Rehmannia Glutinosa Based on Traditional Chinese Medicine Fingerprints
Authors: Geng Xiaotong
Published: August 2022

Research on the active components of medicinal plants has always been the focus of research, and research on the active components of medicinal plant endophytic fungi and their secondary metabolites has also attracted widespread attention. Endophytic fungi of medicinal plants are widely distributed and are ubiquitous in various biological groups in nature. Rehmannia glutinosa contains a variety of active ingredients, which are regarded as the top grade of Chinese medicinal materials. It is of certain significance to study endophytic fungi and their metabolites of Rehmannia glutinosa. In this paper, endophytic fungi and their secondary metabolites of Rehmannia glutinosa were studied using fingerprint technology, which initially understands the diversity of endophytic fungi in Rehmannia glutinosa. In this paper, the roots and leaves of Rehmannia glutinosa were used as experimental materials. The fungi were cultured in the medium, the fungi were isolated and purified by the tissue block method, the fungal growth of Rehmannia glutinosa in different parts was determined, and the types of endophytic fungi were identified by microscopic identification and fingerprinting. The isolated strains were tested for biological activity using oryza oryzae spores, and highly active strains were screened. Fermentation products of endophytic fungi were separated and purified by chromatography, and the structure of the compounds was identified by nuclear magnetic resonance spectroscopy. Through the above studies, the population structure of endophytic fungi of Rehmannia glutinosa was determined, 3 highly active strains were found, and the structures of 7 endophytic fungi metabolites were identified, of which 3 were newly discovered compounds.
A Study on the Effects and Influencing Factors of Agricultural Support and Subsidy Policies from Big Data Computing and Analysis
Authors: Chen Kexin , Wang Zhenyu
Published: August 2022

Agriculture is the backbone of any country in any given situation. Without agriculture, it will be very difficult for any living being to survive. To increase productivity in agriculture, the farmers are dependent on government policies and subsidiaries provided to them. The policies and subsidiaries should support and encourage farmers to work hard and do some innovations in agriculture. In this research work, an agriculture dataset concerning the policies and subsidiaries of China is considered. The research proposed a subsidy distribution algorithm for evaluating the policies. The proposed model provided an accuracy of 98% in determining the research objectives. The study results revealed that procedural support for government subsidy policies and agricultural support is low. It is recommended to increase domestic policy to support agriculture.
Analysis of Vehicle-Pedestrian Accident Risk Based on Simulation Experiments
Authors: Cheng Rui , Pan Ye , Xie Lian
Published: August 2022

Vehicle-pedestrian accidents are one of the main types of road traffic accidents in China because of their mixed traffic features. By analyzing the characteristics of vehicle-pedestrian accidents, the head injury criterion (HIC) was selected as a quantitative index of pedestrian head injury risk, and vehicle-pedestrian collision simulation tests were carried out using PC-Crash. From the collected test data, the multivariate relationship models between the HIC, vehicle speed, and collision angle were fitted for different vehicle types. A risk assessment method for vehicle-pedestrian accidents based on the HIC was proposed by the Fisher optimal segmentation algorithm. Finally, a new index for evaluating the accuracy of accident risk classification, the degree of error classification, was proposed to verify the validity of the accident risk assessment method. The results show that vehicle speed, collision angle, and vehicle type play a key role in pedestrian injury. Flat-headed vehicles are more likely to cause head injuries to pedestrians than high-headed and low-headed vehicles. Rear-end collisions cause more injuries to pedestrians than side collisions. The research results can provide guidance and a basis for accident liability determination, speed limit management, vehicle safety design, and human injury mechanism analysis.
River Pollution by Heavy Metals and Associated Impacts on the Adjacent Community, the Case of Holeta and Golli Rivers, Holeta Town, Ethiopia
Authors: Temesgen Mathewos , Shewamolto Abebe
Published: August 2022

This study aimed to determine the level of heavy metals in the Holeta and Golli rivers and their impacts on the community of Holeta town, Ethiopia. Water samples were collected from eight randomly selected locations (4 sites from each river). A questionnaire survey, FGD, and KII were also used. Secondary data were also taken from the nearby health center. The flame atomic absorption spectrometer was used to analyze the samples. Fe, Mn, Ni, Cr, Pb, Cu, Zn, Co, and Cd were the identified heavy metals. The Holeta River contains Fe > Mn > Zn > Ni > Cr > Cu > Pb > Co > Cd, whereas the Golli River contains Fe > Mn > Zn > Ni > Cr > Cu > Pb > Co > Cd. The levels of Fe, Cr, Ni, Fe, and Mn were above the permissible limit of WHO (1984) and USEPA (1992). The primary sources of income for the people who lived in the area were farming and jobs on flower farms. Wastewaters discharged from the surrounding flower farms were the major polluting source (84.3%) of the river. About 84.3% of the surrounding community claimed that wastewaters discharged from the flower farms are the major polluting sources of both rivers. Many of the flower farmworkers (43.9%) have also exposure to toxic insecticides and pesticides used on the farm. About 60% and 20.5% of the workers have frequent severe headaches and skin irritation due to exposure to heavy metals. Generally, both the surrounding community and flower farmworkers are facing significant health and socioeconomic impacts due to the heavy metals joining the rivers. Therefore, effective management of pollution sources and continuous monitoring of the river quality is very imperative to minimize the impacts.
[Retracted] The Effect of CT‐Guided Artificial Pneumothorax plus Thoracoscopy and Central Venous Catheterization on the Drainage Effect of Pediatric Empyema and Pulmonary Function
Authors: Liu Xiaoping , Yang Yanxia , Ma Xueping , Wang Xin , Ma Bing , Li Shuhua
Published: August 2022

The aim of the study is to investigate the effect of CT‐guided artificial pneumothorax combined with a thoracoscopic and central venous catheter on empyema drainage effect and pulmonary function in children. A total of 82 pediatric patients with empyema admitted to our hospital from January 2020 to December 2021 were retrospectively analyzed. The control group was treated with artificial pneumothorax combined with thoracoscopy. The study group was treated with a CT‐guided and central venous catheter. The operation time, intraoperative bleeding, surgical field exposure, WBC, C‐reactive protein, and pulmonary function were compared between the two groups. The size of effusion and sonographic staging were compared between the two groups. All children underwent spirometry and a maximal incremental cardiopulmonary exercise test. The operation indicators (operation time, intraoperative blood loss, etc.) and adverse reactions were compared between the two groups. The differences in the operation time, intraoperative blood loss, postoperative hospital stay, postoperative drainage volume, and surgical field exposure between the two groups had a statistical significance (P < 0.05); the differences in the body temperature, total peripheral white blood cell count, C‐reactive protein, size of effusion, and sonographic staging between the two groups had no statistical significance (P > 0.05); before operation, the differences in the expression levels of FVC (%), FEV1 (%), FEV1/FVC, and MVV (%) and indicators of cardiopulmonary function including VE/VO2, breathing reserve(%), VD/VT(%), and VO2/work between the two groups had no statistical significance, but at 6 months after operation, FVC (%), FEV1 (%), FEV1/FVC, and MVV (%) in the study group were significantly higher than those in the control group (P < 0.05) and VE/VO2 and VD/VT(%) in the study group were obviously lower than those in the control group (P < 0.05); the incidence rate of chest pain, pulmonary edema, and skin infection in the study group was lower than that in the control group (P < 0.05). CT‐guided artificial pneumothorax combined with thoracoscopic and central venous catheter drainage of empyema in children is more thorough, with less bleeding, less trauma, rapid recovery of pulmonary function, and is worthy of clinical promotion.
Influencing Factors of Students’ Ideological and Political Education, Identity, and Practice Concept Based on Double-Hurdle Model
Authors: Zhao Kai
Published: August 2022

With the further growth of the China’s socialist market economy and the influence of decadent western ideas, in the context of diverse cultural choices and diversified value orientations, social hot issues have become increasingly prominent. Under the background of multicultural choice and multivalue orientation, social hot issues are becoming increasingly prominent. In order to accurately grasp the specific situation of college students’ identification and training of socialist fundamental ideals and put forward targeted countermeasures and suggestions, by referring to economic research methods, this study builds a double-hurdle model, summarizes the significant factors that affect college students’ identification and training of socialist fundamental values, and analyzes the causes of significant factors and irrelevant factors. In this paper, we explore the status quo, optimization countermeasures, and certain influencing factors for students’ identification and practice of socialist core values. Furthermore, this study also puts forward the optimization countermeasures to enhance college students’ identification and training of socialist fundamental values.
Identifying Key Nodes in Complex Networks Based on Local Structural Entropy and Clustering Coefficient
Authors: Li Peng , Wang Shilin , Chen Guangwu , Bao Chengqi , Yan Guanghui
Published: August 2022

Key nodes have a significant impact, both structural and functional, on complex networks. Commonly used methods for measuring the importance of nodes in complex networks are those using degree centrality, clustering coefficient, etc. Despite a wide range of application due to their simplicity, their limitations cannot be ignored. The methods based on degree centrality use only first-order relations of nodes, and the methods based on the clustering coefficient use the closeness of the neighbors of nodes while ignore the scale of numbers of neighbors. Local structural entropy, by replacing the node influence on networks with local structural influence, increases the identifying effect, but has a low accuracy in the case of high clustered networks. To identify key nodes in complex networks, a novel method, which considers both the influence and the closeness of neighbors and is based on local structural entropy and clustering coefficient, is proposed in this paper. The proposed method considers not only the information of the node itself, but also its neighbors. The simplicity and accuracy of measurement improve the significance of characterizing the reliability and destructiveness of large-scale networks. Demonstrations on constructed networks and real networks show that the proposed method outperforms other related approaches.
Hierarchical Clustering Cuckoo Search Optimization Implemented in Optimal Setting of Directional Overcurrent Relays
Authors: Ma Lvbin , Yu Jiangtao
Published: August 2022

This study has proposed a hierarchical clustering cuckoo search optimization (HCSO) to solve the optimal setting problems of directional overcurrent relays (DOCRs) in the power system. Different from the randomly generated stepsize

θ

in traditional CSO, stepsize

θ

in HCSO is updated by a hierarchical clustering mechanism, which can balance the searching priority of exploration and exploitation for each solution. The superiority of HCSO is evaluated by solving the DOCRs coordination problem with the 3-bus, 8-bus, and 9-bus system, presented by linear programming (LP), nonlinear programming (NLP), and mixed integer nonlinear programming (MINLP) forms. Results show that under the same parameter setting conditions, the minimum value of the objective function by HCSO has reduced by

10.93
%

,

2.93
%

, and

0.46
%

, respectively, compared to that of CSO in the experimented cases 2, 3, and 4. It verifies that HCSO is more competitive than CSO in solving the DOCRs optimal setting problem irrespective of the DOCRs number and formulation type.
Qiliqiangxin Capsule Modulates Calcium Transients and Calcium Sparks in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes
Authors: Li Yuxin , Zhang Zhang , Hao Xuezeng , Yu Tingting , Li Sen
Published: August 2022

Background. The therapeutic effects of Qiliqiangxin capsule (QLQX), a Chinese patent medicine, in patients with chronic heart failure are well established. However, whether QLQX modulates cardiac calcium (Ca2+) signals, which are crucial for the heart function, remains unclear. Aim of the Study. This study aimed to evaluate the role of QLQX in modulating Ca2+ signals in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). Materials and Methods. Fluorescence imaging was used to monitor Ca2+ signals in the cytosol and nuclei of hiPSC-CMs. For Ca2+ spark measurements, the line-scan mode of a confocal microscope was used. Results. The QLQX treatment substantially decreased the frequency of spontaneous Ca2+ transients, whereas the amplitude of Ca2+ transients elicited by electrical stimulation did not change. QLQX increased the Ca2+ spark frequency in both the cytosol and nuclei without changing the sarcoplasmic reticulum Ca2+ content. Interestingly, QLQX ameliorated abnormal Ca2+ transients in CMs differentiated from hiPSCs derived from patients with long-QT syndrome. Conclusions. Our findings provide the first line of evidence that QLQX directly modulates cardiac Ca2+ signals in a human cardiomyocyte model.
Dynamic Nonlinear Connectedness between the Financial Inclusion, Economic Growth, and China’s Poverty Alleviation: Evidence from a Panel VAR Analysis
Authors: Chen Zhenhuan , Zhu Hongge , Zhao Wencheng , Cao Bo , Cai Yingli
Published: August 2022

Whether financial inclusion and economic growth can sustainably release poverty alleviation effects in long term has been the focus of academia and government sector. This article uses provincial panel data from 2004 to 2019 to examine the dynamic nonlinear connectedness between the financial inclusion, economic growth, income inequality, and poverty alleviation; the main objective is to reveal the direction and intensity of the long‐term and short‐term impact of each factor on poverty alleviation. By building a panel vector autoregression model (PVAR), the comparison analyses of national, eastern, central, and western sample groups verify the existence of dynamic nonlinear connectedness among the four variables. The study found that there is complex bidirectional causality between these variables, financial inclusion has the long‐term impact on promoting poverty alleviation in China, the impact of economic growth is relatively weak, and income inequality has weakened the positive impact of financial inclusion on poverty alleviation. Through the analysis of impulse response function, variance decomposition, and time‐varying nonparametric estimates in different economic regions, we find that the impact of financial inclusion on poverty alleviation presents a U‐shaped characteristic, and the contribution of financial inclusion to poverty alleviation in western regions is significant, but poverty reduction in eastern and central region mainly depends on economic growth. For policymakers, financial inclusion can be an effective way to alleviate relative poverty, but the poverty governance should focus more on reducing income inequality in China.
[Retracted] Analysis of the Influence of Geographical Environment on Chinese Ethnic Folk Dance, Taking the Development of Dance Curriculum in Huaihua No. 1 Middle School as an Example
Authors: Liu Xin , Ko Young Chun
Published: August 2022

Among the treasures of Chinese art, ethnic dance is an important part. As a key form of expression of national art and emotion, dance has strong regional and gender characteristics for those affected by different ethnic groups and regions. The unique characteristics of the region are the driving force for the masses of all ethnic groups in China to continuously promote the prosperity and development of ethnic and folk dances living alone in different living conditions and living environments. In the analysis of ethnic and folk dances, environmental elements have a profound impact on the rapid development of dance. The main reason for folk dance is the relationship between the costumes of the dance, the connotation of the dance, and the laws of nature, resulting in the derivation of the environment. The article will also focus on a more in‐depth discussion and analysis of the characteristics of Chinese folk dance. Scientific research on the regionality of ethnic dance plays a vital role in understanding and inheriting ethnic and folk dances.
[Retracted] Construction and Analysis of College English Teaching Path under the Multiple Network Teaching Environment and Credit System
Authors: Chong Bin , Tian Zhongshan
Published: August 2022

With the wide spread of the Internet, information technology begins to enter all aspects of people’s lives, such as teaching. The trend of economic globalization and export‐oriented economic development have put forward urgent requirements for the level and quality of English teaching in colleges and universities. However, the current diversified information technology has brought many opportunities and challenges to college English teaching, and the traditional teaching mode can no longer meet the requirements of the new era. Both teachers and students need to communicate and interact through modern network media. Teaching reform has become an inevitable trend. The important premise of deepening college English teaching reform under the credit system is to grasp the needs of students. This paper analyzes the characteristics of the interactive teaching mode, points out the problems and challenges of the traditional English teaching, reveals the achievements and the problems of the reform under the credit system, and concludes that the English teaching mode, which is a practical and effective teaching mode.
A Case of Brachial Lymph Node Recurrences after the Resection of Locally Advanced Breast Cancer
Authors: Onishi Kayono , Watanuki Rurina , Yokoe Takamichi , Iwatani Tsuguo , Yamauchi Chisako , Onishi Tatsuya
Published: August 2022

We present a case of two recurrences in the brachial lymph nodes after initial resection, which was performed for radical cure. A 66-year-old woman was diagnosed with left breast cancer T4bN3cM0 Stage IIIC and an immunohistochemistry assay showed estrogen receptor (ER) positivity (5%), progesterone-receptor (PgR) positivity (1%), human epidermal growth factor receptor-2 (HER2) positivity (3+), and low Ki-67 (15%). After four courses of adriamycin and cyclophosphamide, followed by four courses of trastuzumab plus docetaxel, the patient underwent left mastectomy and axillary dissection. Postoperatively, she was diagnosed with breast cancer ypT1cN0M0, and trastuzumab and anastrozole were started. Postoperative irradiation was performed. Three years and 5 months after the initial breast cancer surgery, she had left brachial lymph node recurrence. It was resected, and tamoxifen was administered postoperatively. One year and 9 months after, she had another left brachial lymph node recurrence, and it was resected. She received radiation therapy to her upper limb and started taking exemestane. After 1 year and 3 months since the second recurrence surgery, there has been no recurrence. Our case suggests that the replacement of regional lymph nodes with tumor cells may result in the reconstruction of lymph flow to the upper arm and the development of brachial lymph node metastasis. There are no reports of resection of the recurrent tumor in the brachial lymph node for curative treatment. Therefore, careful follow-up is important in the future.
Myeloid Sarcoma Mimicking Dental Abscess in a Patient with Chronic Myeloid Leukemia: Diagnostic and Therapeutic Dilemma
Authors: Ali Elrazi A. , Abu-Tineh Mohammad , Abdelrazek Mohamed , Petkar Mahir , Karzoun Mzaki , Subahi Eihab A. , Szabados Lajos , Yassin Mohamed A.
Published: August 2022

Chronic myeloid leukemia (CML) is a hematologic malignancy that has significant improvement in its prognosis after the introduction of tyrosine kinase inhibitors. Transformation to accelerated phase or blast phase can happen. Myeloid sarcoma or chloroma is an uncommon extramedullary disease. It is very unusual for patients with CML to develop myeloid sarcoma. We report a young man with CML in the chronic phase who developed myeloid sarcoma. There were many difficulties in the diagnosis of myeloid sarcoma due to the simulation of other more common conditions like infections and other malignancies. In addition, there are treatment challenges because of lack of standardized treatment. The case shed light on this rare complication, the challenging diagnosis, and its implication in patients with CML.
Clinical Reasoning: Wilbrand’s Knee, Scotoma of Traquair, and Normal Tension Glaucoma
Authors: Pellegrini Francesco , Cuna Alessandra , Cirone Daniele , Ciabattoni Cristina , Caruso Ettore , Interlandi Emanuela , Zappacosta Antonio
Published: August 2022

An otherwise healthy 63-year-old woman was given a diagnosis of normal tension glaucoma (NTG) in the right eye (OD) 2 months before presentation. Standard computerized perimetry showed a unilateral right hemianoptic temporal field defect. On examination visual acuity was preserved, intraocular pressure was normal, there was a right relative afferent pupillary defect (RAPD) with an asymmetric cupping of the disc, but no pallor. Brain magnetic resonance imaging (MRI) showed a meningioma compressing the right optic nerve at its junction with the chiasm. Compressive disorders on the anterior chiasm, albeit rarely, may cause cupping of the disc and unilateral temporal visual field defect (junctional scotoma of Traquair) with normal visual acuity that should be considered in the differential diagnosis of NTG.
The Use of Chatbots as Supportive Agents for People Seeking Help with Substance Use Disorder: A Systematic Review
Authors: Ogilvie Lisa , Prescott Julie , Carson Jerome
Published: August 2022

Introduction: The use of chatbots in healthcare is an area of study receiving increased academic interest. As the knowledge base grows, the granularity in the level of research is being refined. There is now more targeted work in specific areas of healthcare, for example, chatbots for anxiety and depression, cancer care, and pregnancy support. The aim of this paper is to systematically review and summarize the research conducted on the use of chatbots in the field of addiction, specifically the use of chatbots as supportive agents for those who suffer from a substance use disorder (SUD). Methods: A systematic search of scholarly databases using the broad search criteria of (“drug” OR “alcohol” OR “substance”) AND (“addiction” OR “dependence” OR “misuse” OR “disorder” OR “abuse” OR harm*) AND (“chatbot” OR “bot” OR “conversational agent”) with an additional clause applied of “publication date” ≥ January 01, 2016 AND “publication date” ≤ March 27, 2022, identified papers for screening. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used to evaluate eligibility for inclusion in the study, and the Mixed Methods Appraisal Tool was employed to assess the quality of the papers. Results: The search and screening process identified six papers for full review, two quantitative studies, three qualitative, and one mixed methods. The two quantitative papers considered an adaptation to an existing mental health chatbot to increase its scope to provide support for SUD. The mixed methods study looked at the efficacy of employing a bespoke chatbot as an intervention for harmful alcohol use. Of the qualitative studies, one used thematic analysis to gauge inputs from potential users, and service professionals, on the use of chatbots in the field of addiction, based on existing knowledge, and envisaged solutions. The remaining two were useability studies, one of which focussed on how prominent chatbots, such as Amazon Alexa, Apple Siri, and Google Assistant can support people with an SUD and the other on the possibility of delivering a chatbot for opioid-addicted patients that is driven by existing big data. Discussion/Conclusion: The corpus of research in this field is limited, and given the quality of the papers reviewed, it is suggested more research is needed to report on the usefulness of chatbots in this area with greater confidence. Two of the papers reported a reduction in substance use in those who participated in the study. While this is a favourable finding in support of using chatbots in this field, a strong message of caution must be conveyed insofar as expert input is needed to safely leverage existing data, such as big data from social media, or that which is accessed by prevalent market leading chatbots. Without this, serious failings like those highlighted within this review mean chatbots can do more harm than good to their intended audience.
Cognitive Functioning in Long-Term Benzodiazepine Users
Authors: Zetsen Shirley P.G. , Schellekens Arnt F.A. , Paling Erik P. , Kan Cornelis C. , Kessels Roy P.C.
Published: August 2022

Background: Benzodiazepines are widely used in the treatment of anxiety disorders and sleep disturbances, but negative cognitive side effects have been reported after long-term use. Studies on the cognitive effects of long-term benzodiazepine use to date have typically included small samples and limited cognitive assessments. Objectives: This study examined cognitive performance on four cognitive domains in long-term benzodiazepine users, compared to normative data. Furthermore, it was examined whether sex, age, benzodiazepine dose, and state and trait anxiety moderated cognitive functioning in long-term benzodiazepine users. Methods: Neuropsychological tests targeting different cognitive domains were administered to 92 patients with long-term benzodiazepine use who were accepted for enrolment into a benzodiazepine discontinuation programme in an academic hospital. Test scores were compared to a large normative data sample. Results: Of the long-term benzodiazepine users, 20.7% could be classified as cognitively impaired across all domains, with the largest effects found in the domains processing speed and sustained attention, and an overall worse performance in women, an effect which appears to be moderated by state anxiety. No effects of age or benzodiazepine dose were found. Conclusions: These results extend those of earlier studies on benzodiazepine effects on specific cognitive domains. This study implies an overall detrimental cognitive effect in long-term benzodiazepine users rather than specific effects. Therefore, long-term benzodiazepine use should be avoided, and once present, tailored interventions aimed at tapering benzodiazepines are warranted.
The Development of Pulmonary Edema after Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke Patient; Neurogenic or Non-Neurogenic?
Authors: Alwahdy Ahmad Sulaiman , Sihombing Ika Yulieta Margaretha , Alfina Fitria Tahta , Syahdian Niken , Nurbaeti Putri , Futihandayani Annisa , Ramadhanti Allifka
Published: August 2022

Recombinant tissue plasminogen activator (r-tPA) is the first-line drug for the treatment of acute ischemic stroke, despite it may lead to a variety of complications in some cases. In patients with extensive stroke, infarction of the brain can cause suppression of the respiratory center in the brain leading to neurogenic pulmonary edema that potentially causes respiratory failure. Its etiology is either due to a neurogenic or non-neurogenic process. Nevertheless, the definite pathophysiology of these circumstances remains unclear. In this study, we reported four cases of post-thrombolytic ischemic stroke patients who suffer from pulmonary edema with different symptoms and onset times as well as we discuss the possible explanation behind these different outcomes.
Cell Therapy for Type 1 Diabetes: From Islet Transplantation to Stem Cells
Authors: Sordi Valeria , Monaco Laura , Piemonti Lorenzo
Published: August 2022

The field of cell therapy of type 1 diabetes is a particularly interesting example in the scenario of regenerative medicine. In fact, β-cell replacement has its roots in the experience of islet transplantation, which began 40 years ago and is currently a rapidly accelerating field, with several ongoing clinical trials using β cells derived from stem cells. Type 1 diabetes is particularly suitable for cell therapy as it is a disease due to the deficiency of only one cell type, the insulin-producing β cell, and this endocrine cell does not need to be positioned inside the pancreas to perform its function. On the other hand, the presence of a double immunological barrier, the allogeneic one and the autoimmune one, makes the protection of β cells from rejection a major challenge. Until today, islet transplantation has taught us a lot, pioneering immunosuppressive therapies, graft encapsulation, tissue engineering, and test of different implant sites and has stimulated a great variety of studies on β-cell function. This review starts from islet transplantation, presenting its current indications and the latest published trials, to arrive at the prospects of stem cell therapy, presenting the latest innovations in the field.