bluuebunny/crossref_metadata_2025 huggingface dataset:
Portable Respiration Monitoring System with an Embroidered Capacitive Facemask Sensor
Authors: Simić Mitar , Stavrakis Adrian K. , Sinha Ankita , Premčevski Velibor , Markoski Branko , Stojanović Goran M.
Published: May 2022

Respiration monitoring is a very important indicator of health status. It can be used as a marker in the recognition of a variety of diseases, such as sleep apnea, asthma or cardiac arrest. The purpose of the present study is to overcome limitations of the current state of the art in the field of respiration monitoring systems. Our goal was the development of a lightweight handheld device with portable operation and low power consumption. The proposed approach includes a textile capacitive sensor with interdigitated electrodes embroidered into the facemask, integrated with readout electronics. Readout electronics is based on the direct interface of the capacitive sensor and a microcontroller through just one analog and one digital pin. The microcontroller board and sensor are powered by a smartphone or PC through a USB cable. The developed mobile application for the Android™ operating system offers reliable data acquisition and acts as a bridge for data transfer to the remote server. The embroidered sensor was initially tested in a humidity-controlled chamber connected to a commercial impedance analyzer. Finally, in situ testing with 10 volunteering subjects confirmed stable operation with reliable respiration monitoring.
Pentraxin-3 in the Spinal Dorsal Horn Upregulates Nectin-1 Expression in Neuropathic Pain after Spinal Nerve Damage in Male Mice
Authors: Zhu Min , Yu Hongli , Sun Ying , Yu Wenli
Published: May 2022

Purpose: Neuropathic pain often originates from nerve injury or diseases of the somatosensory nervous system. However, its specific pathogenesis remains unclear. The requirement for excitatory synaptic plasticity in pain-related syndromes has been demonstrated. A recent study reported that pentraxin-3 is important in glutamatergic synaptic formation and function. Meanwhile, nectin-1 mediates synaptogenesis in neurological disorders. The present study aimed to evaluate whether pentraxin-3 and nectin-1 modulate spinal nerve damage-related neuropathic pain in male mice. Methods: L4 spinal nerve ligation (SNL) in male mice was performed to induce experimental neuropathic pain. Mechanical allodynia and heat hyperalgesia following SNL were based on paw withdrawal (PW) threshold and PW latency, respectively. Spinal pentraxin-3 levels and nectin-1 expression following SNL were examined. Pentraxin-3 and nectin-1 knockdown models were established by the shRNA method. These models were used with a recombinant pentraxin-3 cell model to investigate the underlying mechanisms of SNL. Results: The SNL operation generated persistent decreases in mechanical PW threshold and thermal PW latency, with subsequent long-lasting elevations in spinal pentraxin-3 and nectin-1 expression levels. Pentraxin-3 knockdown reduced SNL-associated neuropathic pain behaviors as well as nectin-1 amounts in the spinal dorsal horn. Nectin-1 deficiency impaired mechanical allodynia and thermal hyperalgesia following spinal nerve injury. The application of recombinant pentraxin-3 in the spinal cord triggered an acute nociception phenotype and induced spinal overexpression of nectin-1. The intrathecal knockdown of nectin-1 prevented exogenous pentraxin-3-evoked pain hypersensitivity. Conclusions: The findings suggest spinal pentraxin-3 is required for SNL-triggered neuropathic pain via nectin-1 upregulation in male mice.
Processing of an Audiobook in the Human Brain Is Shaped by Cultural Family Background
Authors: Hakonen Maria , Ikäheimonen Arsi , Hultèn Annika , Kauttonen Janne , Koskinen Miika , Lin Fa-Hsuan , Lowe Anastasia , Sams Mikko , Jääskeläinen Iiro P.
Published: May 2022

Perception of the same narrative can vary between individuals depending on a listener’s previous experiences. We studied whether and how cultural family background may shape the processing of an audiobook in the human brain. During functional magnetic resonance imaging (fMRI), 48 healthy volunteers from two different cultural family backgrounds listened to an audiobook depicting the intercultural social life of young adults with the respective cultural backgrounds. Shared cultural family background increased inter-subject correlation of hemodynamic activity in the left-hemispheric Heschl’s gyrus, insula, superior temporal gyrus, lingual gyrus and middle temporal gyrus, in the right-hemispheric lateral occipital and posterior cingulate cortices as well as in the bilateral middle temporal gyrus, middle occipital gyrus and precuneus. Thus, cultural family background is reflected in multiple areas of speech processing in the brain and may also modulate visual imagery. After neuroimaging, the participants listened to the narrative again and, after each passage, produced a list of words that had been on their minds when they heard the audiobook during neuroimaging. Cultural family background was reflected as semantic differences in these word lists as quantified by a word2vec-generated semantic model. Our findings may depict enhanced mutual understanding between persons who share similar cultural family backgrounds.
p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation
Authors: Kondylis Vangelis , Schneider Farina , Schorn Fabian , Oikonomou Nikos , Straub Beate Katharina , Werner Sabine , Rosenstiel Philip , Pasparakis Manolis
Published: May 2022

SQSTM1/p62 is a multitasking protein that functions as an autophagy receptor, but also as a signaling hub regulating diverse cellular pathways. p62 accumulation in mice with autophagy-deficient hepatocytes mediates liver damage and hepatocarcinogenesis through Nrf2 overactivation, yet the role of the p62-Keap1-Nrf2 axis in cell death and hepatocarcinogenesis in the absence of underlying autophagy defects is less clear. Here, we addressed the role of p62 and Nrf2 activation in a chronic liver disease model, namely mice with liver parenchymal cell-specific knockout of NEMO (NEMOLPC-KO), in which we demonstrate that they show no inherent autophagy impairment. Unexpectedly, systemic p62 ablation aggravated the phenotype and caused early postnatal lethality in NEMOLPC-KO mice. Expression of a p62 mutant (p62ΔEx2-5), which retains the ability to form aggregates and activate Nrf2 signaling, did not cause early lethality, but exacerbated hepatocarcinogenesis in these mice. Our immunohistological and molecular analyses showed that the increased tumor burden was only consistent with increased expression/stability of p62ΔEx2-5 driving Nrf2 hyperactivation, but not with other protumorigenic functions of p62, such as mTOR activation, cMYC upregulation or increased fibrosis. Surprisingly, forced activation of Nrf2 per se did not increase liver injury or tumor burden in NEMOLPC-KO mice, suggesting that autophagy impairment is a necessary prerequisite to unleash the Nrf2 oncogenic potential in mice with autophagy-competent hepatocytes.
Machine Learning Algorithm for Distinguishing Ductal Carcinoma In Situ from Invasive Breast Cancer
Authors: Vy Vu Pham Thao , Yao Melissa Min-Szu , Khanh Le Nguyen Quoc , Chan Wing P.
Published: May 2022

Purpose: Given that early identification of breast cancer type allows for less-invasive therapies, we aimed to develop a machine learning model to discriminate between ductal carcinoma in situ (DCIS) and minimally invasive breast cancer (MIBC). Methods: In this retrospective study, the health records of 420 women who underwent biopsies between 2010 and 2020 to confirm breast cancer were collected. A trained XGBoost algorithm was used to classify cancers as either DCIS or MIBC using clinical characteristics, mammographic findings, ultrasonographic findings, and histopathological features. Its performance was measured against other methods using area under the receiver operating characteristic curve (AUC), sensitivity, specificity, accuracy, precision, and F1 score. Results: The model was trained using 357 women and tested using 63 women with an overall 420 patients (mean [standard deviation] age, 57.1 [12.0] years). The model performed well when feature importance was determined, reaching an accuracy of 0.84 (95% confidence interval [CI], 0.76–0.91), an AUC of 0.93 (95% CI, 0.87–0.95), a specificity of 0.75 (95% CI, 0.67–0.83), and a sensitivity of 0.91 (95% CI, 0.76–0.94). Conclusion: The XGBoost model, combining clinical, mammographic, ultrasonographic, and histopathologic findings, can be used to discriminate DCIS from MIBC with an accuracy equivalent to that of experienced radiologists, thereby giving patients the widest range of therapeutic options.
Surgical Resection plus Intraoperative Radiofrequency Ablation versus Chemoembolization for the Treatment of Intermediate-Stage (BCLC B) Hepatocellular Carcinoma with Preserved Liver Function: A Propensity Score-Matched Analysis
Authors: Kim Gun Ha , Kim Jin Hyoung , Ko Heung Kyu , Chu Hee Ho , Kim Seong Ho , Shin Ji Hoon , Gwon Dong Il , Ko Gi-Young , Yoon Hyun-Ki , Kim Ki-Hun , Shim Ju Hyun , Kim Nayoung
Published: May 2022

The purpose of this study was to compare the efficacy and safety of surgical resection (SR) plus intraoperative radiofrequency ablation (IORFA) with transarterial chemoembolization (TACE) in patients with intermediate-stage HCC and Child–Pugh class A liver function. Treatment-naïve patients who received SR plus IORFA (n = 104) or TACE (n = 513) were retrospectively evaluated. Patients were subjected to a maximum 1:3 propensity score matching (PSM), yielding 95 patients who underwent SR plus IORFA and 252 who underwent TACE. Evaluation of the entire study population showed that progression-free survival (PFS) and overall survival (OS) were significantly better in the SR plus IORFA than in the TACE group. After PSM, the median PFS (18.4 vs. 15.3 months) and OS (88.6 vs. 56.2 months) were significantly longer, and OS rate significantly higher (HR: 0.65, p = 0.026), in the SR plus IORFA group than in the TACE group. Stratified Cox regression analysis and doubly robust estimation revealed that treatment type was significantly associated with both OS and PFS. Rates of major complications were similar in the SR plus IORFA and TACE groups. In conclusion, SR plus IORFA showed better survival outcomes than TACE. SR plus IORFA may provide curative treatment to patients with intermediate-stage HCC with ≤4 tumors and Child–Pugh class A.
Cancer Survival in Adults in Spain: A Population-Based Study of the Spanish Network of Cancer Registries (REDECAN)
Authors: Guevara Marcela , Molinuevo Amaia , Salmerón Diego , Marcos-Gragera Rafael , Carulla Marià , Chirlaque María-Dolores , Rodríguez Camblor Marta , Alemán Araceli , Rojas Dolores , Vizcaíno Batllés Ana , Chico Matilde , Jiménez Chillarón Rosario , López de Munain Arantza , de Castro Visitación , Sánchez Maria-José , Ramalle-Gómara Enrique , Franch Paula , Galceran Jaume , Ardanaz Eva
Published: May 2022

The assessment of cancer survival at the population level is essential for monitoring progress in cancer control. We aimed to assess cancer survival and its trends in adults in Spain. Individual records of 601,250 adults with primary cancer diagnosed during 2002–2013 and followed up to 2015 were included from 13 population-based cancer registries. We estimated net survival up to five years after diagnosis and analyzed absolute changes between 2002–2007 and 2008–2013. Estimates were age-standardized. Analyses were performed for 29 cancer groups, by age and sex. Overall, age-standardized five-year net survival was higher in women (61.7%, 95% CI 61.4–62.1%) than in men (55.3%, 95% CI 55.0–55.6%), and ranged by cancer from 7.2% (pancreas) to 89.6% (prostate) in men, and from 10.0% (pancreas) to 93.1% (thyroid) in women in the last period. Survival declined with age, showing different patterns by cancer. Between both periods, age-standardized five-year net survival increased overall by 3.3% (95% CI 3.0–3.7%) in men and 2.5% (95% CI 2.0–3.0%) in women, and for most cancer groups. Improvements were greater in patients younger than 75 years than in older patients. Chronic myeloid leukemia and myeloma showed the largest increases. Among the most common malignancies, the greatest absolute increases in survival were observed for colon (5.0%, 95% CI 4.0–6.0%) and rectal cancers (4.5%, 95% CI 3.2–5.9%). Survival improved even for some cancers with poor prognosis (pancreas, esophagus, lung, liver, and brain cancer). Further investigation of possible sociodemographic inequalities is warranted. This study contributes to the evaluation of cancer control and health services’ effectiveness.
Non-Robustness of Ang’s Risk Classification in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma in Japanese Patients
Authors: Itami Jun , Kobayashi Kenya , Mori Taisuke , Honma Yoshitaka , Kubo Yuko , Murakami Naoya , Omura Go , Okuma Kae , Inaba Koji , Takahashi Kana , Kashihara Tairo , Shimizu Yuri , Takahashi Ayaka , Nakayama Yuko , Matsumoto Fumihiko , Yoshimoto Seiichi , Igaki Hiroshi
Published: May 2022

Background: Validity of the risk classification by Ang for human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) remains to be studied in the patients treated by modalities other than chemoradiotherapy and in Japanese patients. Materials and Methods: Between 2010 and 2018, 122 patients with HPV-related OPSCC in stages III and IV by the TNM classification 7th edition (TNM-7) were treated curatively at a single institution in Japan. The median age was 62.7 years. Over 50% of the patients underwent surgery with or without adjuvant therapy. The influence of multiple factors on survival was analyzed. Results: The amount of smoking dichotomized at 10 pack-year, which was used in Ang’s risk classification, was not predictive of prognosis, and Ang’s risk classification was not significantly influential on prognosis in multivariate analysis. In the patients treated with definitive radiation therapy, Ang’s risk classification was not predictive of the prognosis in univariate analysis. The impact of smoking was significant only in the patients undergoing the definitive operation. Conclusions: Ang’s risk classification was not robust in predicting the prognosis of general Japanese HPV-related OPSCC patients. The amount of smoking might have different prognostic influences depending on the therapeutic method.
Olive Mill Wastewater (OMW) Treatment Using Photocatalyst Media
Authors: Al Bawab Abeer , Abu-Dalo Muna , Khalaf Aya , Abu-Dalo Duaa
Published: May 2022

A new nanophotocatalysts series of M2Zr2O7 (M = Mn, Cu, and Fe) and doped Fe2Zr2O7 systems were prepared via sol-gel using the pechini method, characterized, and tested in photocatalytic degradation of olive mill wastewater (OMW). The photocatalytic degradation of the prepared materials was evaluated by measuring total phenolic compounds (TPCs) using the Folin-Ciocalteu method for variable pH under a commercial LED lamp (45 W). The removal of TPCs was measured at different contact times ranging from 2 h to 6 days. X-ray diffraction (XRD) and transmission electron microscope (TEM) analysis approved the nano size of (5–17 nm) and quasi-spherical morphology of the prepared materials. ICP-OES analysis confirmed the XRD analysis and approved the structure of the prepared materials. Aggregation of the nanomaterials was observed using TEM imaging. Brunauer-Emmett-Teller (BET) analysis measured a 67 m2/g surface area for Fe2Zr2O7. Doping Fe with Mn increased the surface area to 173 m2/g and increased to 187 m2/g with a further increase of the Mn dopant. Increasing the Mn dopant concentration increased both surface area and photocatalytic degradation. The highest degradation of TPCs was observed for Mn2Zr2O7 around 70% at pH 10 and exposure time up to one day.
Performance, Reaction Pathway, and Pretreatment of Au Catalyst Precursor in H2/O2 Atmosphere for the Epoxidation of Propylene
Authors: Yang Zixuan , Su Huijuan , Cheng Yanan , Sun Xun , Sun Libo , Zhao Lijun , Qi Caixia
Published: May 2022

Gas-phase epoxidation of propylene in the copresence of H2 and O2 was performed over the catalyst of Au on as-synthesized TS-1 that contained a small amount of anatase TiO2. The catalytic performance was studied by washing or nonwashing the catalyst precursor to modulate the content of purity (K, Cl) and then calcining the samples in O2 or H2 prior to reaction. The results show that the catalytic performance of Au/TS-1 can be improved without washing (more K+ and Au maintained) and O2 pretreatment. It was found that the calcination in O2 was able to maintain more metallic Au and form more surface-active oxygen species and thus providing a better yield of propylene oxide with the assistance of potassium. Interestingly, more acrolein can be produced over the catalysts with respect to the in situ calcination in O2 than that in H2 when the feed only contained 10% O2 and 10% propylene in argon, while there was no formation of propylene oxide. On the other hand, the catalyst precursor calcined in H2 prefers the formation of successive oxygenates of PO.
The Protection of Zinc against Acute Cadmium Exposure: A Morphological and Molecular Study on a BBB In Vitro Model
Authors: Branca Jacopo J. V. , Carrino Donatello , Paternostro Ferdinando , Morucci Gabriele , Fiorillo Claudia , Nicoletti Claudio , Gulisano Massimo , Ghelardini Carla , Di Cesare Mannelli Lorenzo , Becatti Matteo , Pacini Alessandra
Published: May 2022

Cadmium (Cd) is a well-known occupational and environmental pollutant worldwide, and its toxicity is widely recognised. Cd is reported to increase the permeability of the blood–brain barrier (BBB) and to penetrate and accumulate in the brain. Although many lines of evidence show that Cd toxicity is induced by different mechanisms, one of the best known is the Cd-dependent production of reactive oxygen species (ROS). Zinc is a trace element known as coenzyme and cofactor for many antioxidant proteins, such as metallothioneins and superoxide dismutase enzymes. To date, very little is known about the role of Zn in preventing Cd-induced blood–brain barrier (BBB) alterations. The goal of this study was to test the Zn antioxidant capacity against Cd-dependent alterations in a rat brain endothelial cell line (RBE4), as an in vitro model for BBB. In order to mimic acute Cd poisoning, RBE4 cells were treated with CdCl2 30 µM for 24 h. The protective role of ZnCl2 (50 µM) was revealed by evaluating the cell viability, reactive oxygen species (ROS) quantification, cytochrome C distribution, and the superoxide dismutase (SOD) protein activity. Additionally, the effectiveness of Zn in counteracting the Cd-induced damage was investigated by evaluating the expression levels of proteins already known to be involved in the Cd signalling pathway, such as GRP78 (an endoplasmic reticulum (ER) stress protein), caspase3 pro- and cleaved forms, and BAX. Finally, we evaluated if Zn was able to attenuate the alterations of zonula occludens-1 (ZO-1), one of the tight-junction (TJ) proteins involved in the formation of the BBB. Our data clearly demonstrate that Zn, by protecting from the SOD activity impairment induced by Cd, is able to prevent the triggering of the Cd-dependent signalling pathway that leads to ZO-1 dislocation and downregulation, and BBB damage.
Regulation of Chloroplast ATP Synthase Modulates Photoprotection in the CAM Plant Vanilla planifolia
Authors: Wang Hui , Wang Xiao-Qian , Xing Yi-Zhang , Zhao Qing-Yun , Zhuang Hui-Fa , Huang Wei
Published: May 2022

Generally, regulation of cyclic electron flow (CEF) and chloroplast ATP synthase play key roles in photoprotection for photosystems I and II (PSI and PSII) in C3 and C4 plants, especially when CO2 assimilation is restricted. However, how CAM plants protect PSI and PSII when CO2 assimilation is restricted is largely known. In the present study, we measured PSI, PSII, and electrochromic shift signals in the CAM plant Vanilla planifolia. The quantum yields of PSI and PSII photochemistry largely decreased in the afternoon compared to in the morning, indicating that CO2 assimilation was strongly restricted in the afternoon. Meanwhile, non-photochemical quenching (NPQ) in PSII and the donor side limitation of PSI (Y(ND)) significantly increased to protect PSI and PSII. Under such conditions, proton gradient (∆pH) across the thylakoid membranes largely increased and CEF was slightly stimulated, indicating that the increased ∆pH was not caused by the regulation of CEF. In contrast, the activity of chloroplast ATP synthase (gH+) largely decreased in the afternoon. At a given proton flux, the decreasing gH+ increased ∆pH and thus contributed to the enhancement of NPQ and Y(ND). Therefore, in the CAM plant V. planifolia, the ∆pH-dependent photoprotective mechanism is mainly regulated by the regulation of gH+ rather than CEF when CO2 assimilation is restricted.
Early and Innovative Rehabilitation in Warkany Syndrome 2 Associated with Agenesis of the Corpus Callosum: A Case Report
Authors: Settimo Carmela , Bonanno Lilla , Tresoldi Maria , Muratore Rosalia , Cucinotta Francesca , Tripodi Emanuela , Piccolo Adriana , Anchesi Smeralda , Impallomeni Caterina
Published: May 2022

Trisomy 8 mosaicism syndrome (T8MS) or “Warkany’s syndrome 2” is a rare chromosomal disorder characterized by three copies of chromosome 8 in some cells of the body. T8MS incidence in the world population is about 1/25,000–50,000 live births with a 5:1 ratio between males and females. Since chromosomal mosaicism is often present in this syndrome, affected subjects present a phenotype varying from mild dysmorphism to severe structural anomalies. Malformations, including corpus callosum agenesis and renal abnormalities, have been described by many studies. We present a case in a girl 36 months in age, born to assisted fertilization (FIVET) and prenatal diagnosis by amniocentesis. In a fetus in the 22 week of gestation, she presented trisomy 8 mosaicism with ventriculomegaly, agenesis of the corpus callosum and a sequence of polymalformations. Through the early identification of symptoms that gradually occurred during development, the girl was submitted, early, to innovative complex instrumental using virtual reality (VR) rehabilitation. This study involves continuous monitoring and early management of symptoms, with the aim of improving the neurobehavioral outcomes of children with this rare disease by inducing structural neuroplastic responses and significantly reducing the impact that this disorder has on the development of children born without corpus callosum.
Comparison of Surgical Outcomes of Laparoscopic Glue and Laparoscopic Suture Hernioplasty in Pediatric Female Inguinal Hernia
Authors: Ho In Geol , Ihn Kyong , Jeon Ho Jong , Na Yonghyun , Lee Dongeun , Han Seok Joo
Published: May 2022

This study aimed to report the surgical outcomes of laparoscopic glue hernioplasty (LGH) compared with conventional laparoscopic suture hernioplasty (LSH) in pediatric female inguinal hernia repair. We retrospectively analyzed 465 female pediatric patients who underwent laparoscopic inguinal hernia repair between January 2013 and December 2020. LGH and LSH were performed in 95 and 370 cases, respectively. Surgical outcomes (length of hospital stay, operative time, complications, and recurrences) were compared between the LGH and LSH groups. We found that the operation times for bilateral hernia repair were shorter in the LGH group (LGH: 35.5 ± 8.2 min, LSH: 45.2 ± 11.6 min; p < 0.001). No significant differences in complications or recurrences were observed between the two groups during the follow-up period. Our findings suggest that LGH is a feasible and easily applied surgical technique for the treatment of pediatric female inguinal hernia.
Vitamin D and Parathyroid Hormone during Growth Hormone Treatment
Authors: Durá-Travé Teodoro , Gallinas-Victoriano Fidel
Published: May 2022

Background. There is some controversy concerning a potential interaction between vitamin D and PTH and the GH/IGF-1 axis. The goal of this study is to assess vitamin D and PTH status in children with GH deficiency at diagnostic and during treatment with rhGH. Methods. Longitudinal and descriptive study in 110 patients, aged 3.3–9.1 years, with GH deficiency (GHD group) treated with rhGH. At diagnosis and after 12, 24, 36, and 48 months of treatment, a clinical (height, weight, and bone age) and laboratory (phosphorus, calcium, calcidiol, PTH, IGF-1) evaluation was performed. Concurrently, 377 healthy children, aged 3.8–9.7 years, were enrolled and constituted a control group. Vitamin D status was stated in accordance to the U.S. Endocrine Society criteria. Results. No significant differences were found in the prevalence of vitamin D deficiency among control (11.43%) and GHD (13.6%) groups at the moment of diagnosis, remaining without significant changes at 12 (12.9%), 24 (14.6%), 36 (13.1%), and 48 months (13.3%) of treatment. There were not any significant differences in serum levels of calcium, phosphorus, and calcidiol, but a steady increase (p < 0.001) in PTH was detected. Conclusions. Prepubertal patients with GH deficient do not appear to have a higher risk of vitamin D deficiency than healthy subjects, and with treatment with rhGH, no changes in the organic content of vitamin D were observed although a significant increase in PTH levels was detected.
A Severe Systemic Infection in a 14-Year-Old Boy That Took Place during the COVID-19 Pandemic
Authors: Główczewski Adam , Gałązka Przemysław , Peikow Agata , Kojro-Wojcieszonek Anna , Tunowska Dominika , Krogulska Aneta
Published: May 2022

Introduction: Since March 2020, the COVID-19 pandemic has been a global talking point. Access to health care has become more difficult, and such an obstacle increase the risk of inadequate medical care, especially among paediatric patients. Case: This report describes the case of a previously healthy teenager who was staying home for 2 months due to a strict lockdown period in the COVID-19 pandemic and was admitted to hospital for fever, nausea and lumbar pain. He was diagnosed consecutively with meningitis, sepsis, paraspinal abscesses and endocarditis. Further investigation did not reveal any risk factors or immunodeficiency in the patient. Discussion: Sepsis is defined as the presence of systemic inflammatory response syndrome (SIRS) associated with a probable or documented infection. It is the leading cause of death from infection, especially if not recognized and treated quickly. Sepsis may lead to various complications, such as infective endocarditis, meningitis and abscesses. Although such complications may initially be latent, they can promote internal organ dysfunction and the possibility of their presence should be considered in any patient with systemic infection. Any child with a fever should be treated as one with the possibility of developing a severe infection. Conclusion: The presented case shows that even a previously healthy child staying in long-term home isolation can develop a severe infection with multiorgan complications, and the COVID-19 pandemic should not extend the diagnostic process in patients with symptoms of infection.
A Glance at the Molecules That Regulate Oligodendrocyte Myelination
Authors: Wang Shunqi , Wang Yingxing , Zou Suqi
Published: May 2022

Oligodendrocyte (OL) myelination is a critical process for the neuronal axon function in the central nervous system. After demyelination occurs because of pathophysiology, remyelination makes repairs similar to myelination. Proliferation and differentiation are the two main stages in OL myelination, and most factors commonly play converse roles in these two stages, except for a few factors and signaling pathways, such as OLIG2 (Oligodendrocyte transcription factor 2). Moreover, some OL maturation gene mutations induce hypomyelination or hypermyelination without an obvious function in proliferation and differentiation. Herein, three types of factors regulating myelination are reviewed in sequence.
Deposition and Application of Indium-Tin-Oxide Films for Defrosting Windscreens
Authors: Ramanauskas Ruslanas , Iljinas Aleksandras , Marcinauskas Liutauras , Milieška Mindaugas , Kavaliauskas Žydrūnas , Gecevičius Giedrius , Čapas Vytautas
Published: May 2022

The plasma-activated reactive evaporation technique was used for the formation of indium-tin-oxide (ITO) films. The ITO films were deposited on a heated (up to 350 °C) glass substrates using various mass ratios of indium and tin. The optical and electrical properties of the deposited ITO films were determined. The influence of the indium-to-tin mass ratio on the optical transmittance, bandgap, resistivity and resistance of ITO films was investigated. The bandgap of ITO films was increased from 3.18 to 3.37 eV, and the MIn/MSn ratio increased from 4.25 to 10.00. The average values of optical transmittance at the visible light wavelengths increased from ~43% to ~64% as tin mass was reduced. We demonstrated that ITO films with low resistivity ranging from 7.4 × 10−3 to 43.7 × 10−3 Ω·cm were obtained, and the MIn/MSn ratio changed from 4.25 to 10.00. The ITO film formed at the 9.25 MIn/MSn ratio demonstrated high transparency, a wide bandgap and optimal resistivity and resistance values. The heating characteristics indicated that the frozen ice on the ITO films was completely removed after 30 s when the applied voltage was 24 V.
Verification of the Non-Axisymmetric Deformation Mechanism of Bearing Rings after Quenched in a Multi-Field Coupled Simulation
Authors: Liu Qian , Ju Dongying , Li Xusheng , Ishikawa Kousuke , Lv Rui , Lian Weifeng , Zhang Min
Published: May 2022

In this paper, the elliptical deformation mechanism of the bearing ring after quenching has been studied by using the theory of “metal-thermal-mechanical” and the multi-field coupling simulation method. It has been mainly considered that it occurred as an experimental phenomenon in the past that, when the bearing ring had been oil quenched, a vapor film had usually formed on its surface, and the breakage and boiling of the vapor film had been observed to be uneven in a circumferential direction. For this reason, based on the phase transition kinetics, several types of heat transfer boundary conditions on the outer surface of bearing rings during oil quenching have been assumed, and the multi-field coupled simulation of the quenching process of bearing rings has been carried out in this paper. According to the simulation results, it could be concluded that when two different heat transfer boundary conditions have been set on the outer surface of the bearing outer ring in the form of orthogonal symmetry, the quenched bearing outer ring would produce elliptical deformation. The above simulation results have been basically verified by comparing the experimental results.
Defective ZnO Nanoflowers Decorated by Ultra-Fine Pd Clusters for Low-Concentration CH4 Sensing: Controllable Preparation and Sensing Mechanism Analysis
Authors: Chen Yang , Zhang Wenshuang , Luo Na , Wang Wei , Xu Jiaqiang
Published: May 2022

To detect low concentration of CH4 is indeed meaningful in industrial manufacturing, such as the petrochemical industry and natural gas catalysis, but it is not easy to detect low concentration of CH4 due to its high symmetrical and stable structure. In this work, defect-rich ZnO1−x nanoflowers (NFs) were synthesized by a two-step route so as to obtain defect-enhanced gas-sensing performance, namely hydrothermal synthesis followed by H2 treatment. In order to achieve low-concentration detection of CH4, the ultra-thin Pd clusters’ (Cs, diameter about 1–2 nm) sensitizer was synthesized and decorated onto the surface of ZnO1−x NFs. It is found that Pd Cs-2/ZnO1−x gas sensors show enhanced gas-sensing properties to CH4, even at ppm concentration level. At its optimal working temperature of 260 °C, the gas response to 50 ppm CH4 can reach 5.0 with good gas selectivity; the response and recovery time is only 16.2 and 13.8 s, respectively. In the Results, we discussed the CH4 gas-sensing mechanism deeply. Overall, it is very necessary to detect low-concentration methane safely. It is possible for further safe detection of low-concentration methane gas in the future.
Synthesis and Characterization of Ti-Ta-Shape Memory Surface Alloys Formed by the Electron-Beam Additive Technique
Authors: Ormanova Maria , Dechev Dimitar , Ivanov Nikolay , Mihai Geanina , Gospodinov Marin , Valkov Stefan , Enachescu Marius
Published: May 2022

The electron-beam cycling additive technique was proposed for the formation of shape memory Ti-Ta coatings on titanium substrate. On a commercially pure Ti plate, Ta film with a thickness of about 4 μm was deposited by direct current (DC) magnetron sputtering. The sample was then subjected to an electron-beam surface alloying by a scanning electron beam. On the already-formed Ti-Ta surface alloy, a Ta coating with the same thickness was further deposited and the specimen was again subjected to electron-beam alloying for the second cycle. The same procedure was repeated for the third cycle. The structure obtained after each cycle Ti-Ta coatings was studied by X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), and Energy-dispersive X-ray spectroscopy (EDX). The Young’s modulus, hardness, and shape memory effect (SME) were studied by nanoindentation experiments. The results showed that the thickness of the Ti-Ta coatings is about 50 μm in all cases, where the Ta content increases after each technological cycle. It was found that the obtained phase composition is in the form of a double-phase structure of α’ martensitic and β phases, where the highest amount of beta is registered in the case of the Ti-Ta coating obtained after the third cycle. The results obtained for the Young’s modulus and hardness showed that both mechanical characteristics decrease significantly after each cycle. Additionally, the elastic depth recovery ratio increases with an increase in the number of cycles.
Surface and Void Space Analysis of the Crystal Structures of Two Lithium Bis(pentafluoroethanesulfonyl)imide Salts
Authors: Collart Anne , Zeller Matthias , Hillesheim Patrick C.
Published: May 2022

Analysis of two crystal structures of lithium bis(pentafluoroethanesulfonyl)imide is presented. Two orientations of the anion, that is a cis and trans orientation, are observed. Both structures exhibit unique interactions leading to the formation of discrete fluorous domains in the solid-state. A notable difference in the F···F interactions is seen when contrasting the two orientations wherein the trans geometry has a higher percentage of fluorine interactions than the cis orientation. The inclusion of water molecules in one of the structures also leads to the formation of a polar domain formed through a series of cyclical hydrogen bonding rings. The two structures allow for a detailed examination of the bond distances and angles involved in the formation of the two structures. Analysis of the void space in the two structures leads to the observation that the trans conformation exhibits notably higher void space as compared with the cis orientation. Hirshfeld surface analysis is used to help rationalize the interactions leading to unique changes in geometries and structure.
Ni-CeO2 Catalyst with High Ni Loading Prepared by Salt-Assisted Solution Combustion for CO2 Methanation
Authors: Han Cui , Cao Zhongqi , Yang Jiliang , Lu Xinkang , Liu Hui , Jin Zheyu , Zhang Ying , Yang Shuqing , Zheng Xianmin , Wang Luhui
Published: May 2022

An Ni-CeO2 catalyst with high Ni loading (50 wt.%) prepared by a salt-assisted solution combustion method was characterized by different methods and used for CO2 methanation. The specific surface area of the Ni-CeO2 catalyst prepared by salt-assisted solution combustion is 7 times that of the catalyst prepared by conventional solution combustion. The Ni-CeO2 catalyst prepared by salt-assisted solution combustion has smaller particle sizes of Ni and exhibits excellent activity at low temperatures. The high Ni loading and small Ni particle size can provide more metal Ni site and Ni-CeO2 interface, which help to improve the CO2 methanation performance.
High-Efficiency p-n Homojunction Perovskite and CIGS Tandem Solar Cell
Authors: Hedayati Maryam , Olyaee Saeed
Published: May 2022

Efficiency has been known to be one of the most important factors in a solar cell. This article presents the results of a simulation performed on a perovskite/CIGS dual-junction solar cell. In this report, first, a top solar cell consisting of a perovskite absorber layer is simulated using the pn-junction; the separation and transfer of carriers in this structure are done by the internal electric field. The pn-junction has a discharge area smaller than the pin-junction, which increases carrier recombination and reduces optical losses. The perovskite band gap of 1.9 eV is considered, and the efficiency is 21.65% using the Au electrode. Then, the bottom solar cell is fabricated with a CIGS absorbent layer with a 1.4 eV band gap and an efficiency of 11.46%. After simulating and evaluating the performance of the top and bottom solar cells independently, both cells were simulated and examined for the dual-junction state. Since the perovskite and CIGS band gaps are both adjustable, these two materials can act as a proper partner for an absorbent layer in a dual-junction solar cell. In this structure, instead of the usual connection of p-i-n and n-i-p perovskite, n-type and p-type homojunction perovskite connection is used, in which the transfer and separation of carriers are done by an internal electric field. Due to the fact that in this structure, the discharge area is smaller, the recombination of carriers is increased, and the light losses are reduced, which will increase the absorption and efficiency of the cell. The results show that in the tandem design, we encounter an increase in Voc (2.25 V), thus increasing the efficiency of the solar cell (30.71%).
Effect of Mn Concentration on the Structural, Ferroelectric, Optical, and Magnetic Properties of BiFeO3 Nanoparticles
Authors: Kumar Shalendra , Kumari Kavita , Khan Mohammad Rizwan , Malik Maqsood Ahmad , Kumar Rajesh , Dalela Saurabh , Koo Bon Heun
Published: May 2022

In the present work, Bi1.05Fe1−xMnxO3, (x = 0, 0.01, 0.03, 0.05, 0.07, 0.10) NPs were synthesized successfully using the sol-gel technique followed by annealing at 550 °C. The synthesized NPs were investigated for their structural, ferroelectric, optical, and magnetic properties through X-ray diffraction, P-E (polarization vs. electric field) hysteresis loops, UV-vis absorption spectroscopy, Photoluminescence (PL) spectroscopy, and DC-magnetization. The analysis of XRD patterns revealed that the crystallite sizes, lattice parameters, and strain were found to be reduced with an increase in Mn concentration. The ferroelectric properties were studied from the P-E hysteresis loops, which revealed the maximum remnant polarization obtained for Bi1.05Fe0.95Mn0.05O3 NPs. The UV-vis and PL spectra revealed excellent optical properties indicating a reduction (1.91–1.36 eV) in the bandgap with an increase in Mn concentration. The magnetic properties were investigated through the magnetic field (H) dependent magnetization (M) hysteresis loops. The saturation magnetization was found to be maximum (~1.4 emu/g) for Bi1.05Fe0.90Mn0.10O3 NPs. The MH hysteresis loops narrow down near H = 0 forming a wasp waist shape that is maximum for Bi1.05Fe0.90Mn0.10O3 NPs and may be associated with the presence of the canted spins.
Patient Experience with a Gynecologic Oncology-Initiated Genetic Testing Model for Women with Tubo-Ovarian Cancer
Authors: Sadinsky Michaela Bercovitch , Power Joanne , Ambrosio Enza , Palma Laura , Zeng Xing , Foulkes William D. , Weber Evan
Published: May 2022

Background: Up to 20% of women diagnosed with tubo-ovarian carcinoma carry a germline pathogenic variant in a cancer-predisposing gene (e.g., BRCA1/BRCA2). Identifying these variants can help to inform eligibility for therapies, guide surveillance and prevention of new primary cancers, and assess risk to family members. The Gynecologic Oncology-Initiated Genetic Testing Model (GOIGT) was initiated at the McGill University Health Centre (MUHC) to streamline universal germline genetic testing for this population, while addressing the limited resources in the public healthcare system. This study aimed to evaluate the patient experience of participating in this model. Methods: Study participants were patients diagnosed with high-grade non-mucinous epithelial tubo-ovarian cancer who underwent genetic testing through the GOIGT model between 1 January 2017 and 31 December 2020. Eligible participants completed the retrospective questionnaires at least one month after result disclosure. Results: A total of 126 patients were tested through the GOIGT model during the study period, of which 56 were invited to participate. Thirty-four participants returned the study questionnaire. Overall, participants did not report decision regret following the genetic testing and were satisfied with the GOIGT model. Participants reported low levels of uncertainty and distress related to the implications of their test results for themselves and their family members. Conclusions: The results of this study support the continued implementation of mainstreamed genetic testing models for women with high-grade non-mucinous tubo-ovarian cancer. Further studies are required to compare experiences for patients with different genetic test results.
Effects of Bamboo Forest Type and Density on the Growth of Bletilla striata and Root Endophytic Fungi
Authors: Fu Hao , Song Zhilin , Li Shanmin , Lan Siren , Zeng Xinhua , Huang Weichang
Published: May 2022

Bletilla striata is a terrestrial orchid with high ornamental and medicinal values that is widely interplanted in bamboo forests. However, little is known about the effects of bamboo forest type and density on the growth of B. striata and its symbiotic relationship with root endophytic fungi. In this study, the growth state of B. striata, the community composition and diversity of its root endophytic fungal, and the fungal nutritional function were investigated in Phyllostachys edulis, P. iridescens and P. glauca forests with three densities. We found that the type and density of the bamboo forest had significant effects on the growth of B. striata, with the biomass, leaf width, root quantity and width being the highest in the low-density of the P. edulis forest. The community composition and abundance of root endophytic fungi in B. striata varied among different bamboo forests and densities, with P. edulis and P. iridescens forests dominated by Basidiomycota and Serendipita, while P. glauca prevailed by Ascomycota and Dactylonectria. The trophic modes of root endophytic fungi were also affected by forest types and densities. The abundance of symbiotroph fungi was the highest in P. edulis and P. iridescens forests and greatly varied with density gradient, and saprotrophic fungi comprised the highest proportion in the Ph. glauca forest. These results provide basic data for further research and the configuration between bamboo species and terrestrial orchids.
Cardiovascular Risk Stratification in Diabetic Retinopathy via Atherosclerotic Pathway in COVID-19/Non-COVID-19 Frameworks Using Artificial Intelligence Paradigm: A Narrative Review
Authors: Munjral Smiksha , Maindarkar Mahesh , Ahluwalia Puneet , Puvvula Anudeep , Jamthikar Ankush , Jujaray Tanay , Suri Neha , Paul Sudip , Pathak Rajesh , Saba Luca , Chalakkal Renoh Johnson , Gupta Suneet , Faa Gavino , Singh Inder M. , Chadha Paramjit S. , Turk Monika , Johri Amer M. , Khanna Narendra N. , Viskovic Klaudija , Mavrogeni Sophie , Laird John R. , Pareek Gyan , Miner Martin , Sobel David W. , Balestrieri Antonella , Sfikakis Petros P. , Tsoulfas George , Protogerou Athanasios , Misra Durga Prasanna , Agarwal Vikas , Kitas George D. , Kolluri Raghu , Teji Jagjit , Al-Maini Mustafa , Dhanjil Surinder K. , Sockalingam Meyypan , Saxena Ajit , Sharma Aditya , Rathore Vijay , Fatemi Mostafa , Alizad Azra , Viswanathan Vijay , Krishnan Padukode R. , Omerzu Tomaz , Naidu Subbaram , Nicolaides Andrew , Fouda Mostafa M. , Suri Jasjit S.
Published: May 2022

Diabetes is one of the main causes of the rising cases of blindness in adults. This microvascular complication of diabetes is termed diabetic retinopathy (DR) and is associated with an expanding risk of cardiovascular events in diabetes patients. DR, in its various forms, is seen to be a powerful indicator of atherosclerosis. Further, the macrovascular complication of diabetes leads to coronary artery disease (CAD). Thus, the timely identification of cardiovascular disease (CVD) complications in DR patients is of utmost importance. Since CAD risk assessment is expensive for low-income countries, it is important to look for surrogate biomarkers for risk stratification of CVD in DR patients. Due to the common genetic makeup between the coronary and carotid arteries, low-cost, high-resolution imaging such as carotid B-mode ultrasound (US) can be used for arterial tissue characterization and risk stratification in DR patients. The advent of artificial intelligence (AI) techniques has facilitated the handling of large cohorts in a big data framework to identify atherosclerotic plaque features in arterial ultrasound. This enables timely CVD risk assessment and risk stratification of patients with DR. Thus, this review focuses on understanding the pathophysiology of DR, retinal and CAD imaging, the role of surrogate markers for CVD, and finally, the CVD risk stratification of DR patients. The review shows a step-by-step cyclic activity of how diabetes and atherosclerotic disease cause DR, leading to the worsening of CVD. We propose a solution to how AI can help in the identification of CVD risk. Lastly, we analyze the role of DR/CVD in the COVID-19 framework.
The Role of Magnetic Resonance Enterography in Crohn’s Disease: A Review of Recent Literature
Authors: Biondi Marysol , Bicci Eleonora , Danti Ginevra , Flammia Federica , Chiti Giuditta , Palumbo Pierpaolo , Bruno Federico , Borgheresi Alessandra , Grassi Roberta , Grassi Francesca , Fusco Roberta , Granata Vincenza , Giovagnoni Andrea , Barile Antonio , Miele Vittorio
Published: May 2022

Inflammatory bowel disease (IBD) is the term used to identify a form of chronic inflammation of the gastrointestinal tract that primarily contemplates two major entities: ulcerative colitis (UC) and Crohn’s disease (CD). The classic signs are abdominal pain and diarrhoea that correlate with the localization of gastro-enteric disease, although in this pathology extraintestinal symptoms may coexist. The diagnosis of CD relies on a synergistic combination of clinical, laboratory (stool and biochemical), cross-sectional imaging evaluation, as well as endoscopic and histologic assessments. The purpose of this paper is to prove the role of imaging in the diagnosis and follow-up of patients with CD with particular focus on recent innovations of magnetic resonance enterography (MRE) as a pivotal diagnostic tool, analysing the MRE study protocol and imaging features during the various phases of disease activity and its complications.
Fractal Dimension Analysis of Earth Magnetic Field during 26 August 2018 Geomagnetic Storm
Authors: Wawrzaszek Anna , Modzelewska Renata , Krasińska Agata , Gil Agnieszka , Glavan Vasile
Published: May 2022

We analyse the fractal nature of geomagnetic field northward and eastward horizontal components with 1 min resolution measured by the four stations Belsk, Hel, Sodankylä and Hornsund during the period of 22 August–1 September, when the 26 August 2018 geomagnetic storm appeared. To reveal and to quantitatively describe the fractal scaling of the considered data, three selected methods, structure function scaling, Higuchi, and detrended fluctuation analysis are applied. The obtained results show temporal variation of the fractal dimension of geomagnetic field components, revealing differences between their irregularity (complexity). The values of fractal dimension seem to be sensitive to the physical conditions connected with the interplanetary shock, the coronal mass ejection, the corotating interaction region, and the high-speed stream passage during the storm development. Especially, just after interplanetary shock occurrence, a decrease in the fractal dimension for all stations is observed, not straightforwardly visible in the geomagnetic field components data.