bluuebunny/crossref_metadata_2025 huggingface dataset:
IBD Subtype-Regulators IFNG and GBP5 Identified by Causal Inference Drive More Intense Innate Immunity and Inflammatory Responses in CD Than Those in UC
Authors: Gao Sheng , Li Yichen , Wu Dingfeng , Jiao Na , Yang Li , Zhao Rui , Xu Zhifeng , Chen Wanning , Lin Xutao , Cheng Sijing , Zhu Lixin , Lan Ping , Zhu Ruixin
Published: April 2022

Background: The pathological differences between Crohn’s disease (CD) and ulcerative colitis (UC) are substantial and unexplained yet. Here, we aimed to identify potential regulators that drive different pathogenesis of CD and UC by causal inference analysis of transcriptome data.

Methods: Kruskal–Wallis and Dunnett’s tests were performed to identify differentially expressed genes (DEGs) among CD patients, UC patients, and controls. Subsequently, differentially expressed pathways (DEPs) between CD and UC were identified and used to construct the interaction network of DEPs. Causal inference was performed to identify IBD subtype-regulators. The expression of the subtype-regulators and their downstream genes was validated by qRT-PCR with an independent cohort.

Results: Compared with the control group, we identified 1,352 and 2,081 DEGs in CD and UC groups, respectively. Multiple DEPs between CD and UC were closely related to inflammation-related pathways, such as NOD-like receptor signaling, IL-17 signaling, and chemokine signaling pathways. Based on the priori interaction network of DEPs, causal inference analysis identified IFNG and GBP5 as IBD subtype-regulators. The results with the discovery cohort showed that the expression level of IFNG, GBP5, and NLRP3 was significantly higher in the CD group than that in the UC group. The regulation relationships among IFNG, GBP5, and NLRP3 were confirmed with transcriptome data from an independent cohort and validated by qRT-PCR.

Conclusion: Our study suggests that IFNG and GBP5 were IBD subtype-regulators that trigger more intense innate immunity and inflammatory responses in CD than those in UC. Our findings reveal pathomechanical differences between CD and UC that may contribute to personalized treatment for CD and UC.
The Emerging Role of N6-Methyladenosine RNA Methylation as Regulators in Cancer Therapy and Drug Resistance
Authors: Chen Zhaolin , Hu Ying , Jin Le , Yang Fan , Ding Haiwen , Zhang Lei , Li Lili , Pan Tingting
Published: April 2022

N6-methyladenosine (m6A) RNA methylation has been considered the most prevalent, abundant, and conserved internal transcriptional modification throughout the eukaryotic mRNAs. Typically, m6A RNA methylation is catalyzed by the RNA methyltransferases (writers), is removed by its demethylases (erasers), and interacts with m6A-binding proteins (readers). Accumulating evidence shows that abnormal changes in the m6A levels of these regulators are increasingly associated with human tumorigenesis and drug resistance. However, the molecular mechanisms underlying m6A RNA methylation in tumor occurrence and development have not been comprehensively clarified. We reviewed the recent findings on biological regulation of m6A RNA methylation and summarized its potential therapeutic strategies in various human cancers.
RRx-001 Exerts Neuroprotection Against LPS-Induced Microglia Activation and Neuroinflammation Through Disturbing the TLR4 Pathway
Authors: Fang Jie , She Jing , Lin Fang , Wu Jun-Chao , Han Rong , Sheng Rui , Wang Guanghui , Qin Zheng-Hong
Published: April 2022

Neuroinflammation plays an important role in the pathogenesis of many central nervous system diseases. Here, we investigated the effect of an anti-cancer compound RRx-001 on neuroinflammation and its possible new applications. BV2 cells and primary microglia cells were used to evaluate the role of RRx-001 in LPS-induced microglial activation and inflammatory response in vitro. And, we found that the increase in the synthesis and release of cytokines and the up-regulation of pro-inflammatory factors in LPS-treated microglial cells were significantly reduced by RRx-001 pretreatment. As the most classical inflammatory pathways, NF-κB and MAPK signaling pathways were activated by LPS, but were inhibited by RRx-001. Transcription of NLRP3 was also reduced by RRx-001. In addition, LPS induced oxidative stress by increasing the expression of Nox mediated by transcription factors NF-κB and AP-1, while RRx-001 pretreatment ameliorated Nox-mediated oxidative stress. LPS-induced activation of TAK1, an upstream regulator of NF-κB and MAPK pathways, was significantly inhibited by RRx-001 pretreatment, whereas recruitment of MyD88 to TLR4 was not affected by RRx-001. LPS-primed BV2 condition medium induced injury of primary neurons, and this effect was inhibited by RRx-001. Furthermore, we established a neuroinflammatory mouse model by stereotactic injection of LPS into the substantia nigra pars compacta (SNpc), and RRx-001 dose-dependently reduced LPS-induced microglial activation and loss of TH + neurons in the midbrain. In conclusion, the current study found that RRx-001 suppressed microglia activation and neuroinflammation through targeting TAK1, and may be a candidate for the treatment of neuroinflammation-related brain diseases.
Modulating the Band Alignments of Two-Dimensional In2Se3/InSe Heterostructure via Ferroelectric Polarization and Interlayer Coupling
Authors: Du Yabing , Wang Xiaolong , Dai Xianqi , Li Wei
Published: April 2022

Two-dimensional (2D) ferroelectric materials with robust polarization down to atomic thicknesses provide novel building blocks for functional heterostructures. The effects of ferroelectric polarization on the electronic properties of 2D ferroelectric heterostructures are rarely investigated. Here, based on the first-principles calculations, we study the effect of ferroelectric polarization and interlayer coupling on the electronic properties of the 2D In2Se3/InSe ferroelectric heterostructure. It is found that the ferroelectric polarization of In2Se3 can effectively tune the band alignments of the In2Se3/InSe heterostructure. When the direction of ferroelectric polarization is reversed (i.e., from up to down), the band alignments of In2Se3/InSe heterostructures transition from type I to type II. Meanwhile, we find that the transition between type I and type II band alignments can be induced by means of interlayer coupling (i.e., varying interlayer distances). The results demonstrate that ferroelectric polarization and interlayer coupling are effective methods to modulate the band alignments of In2Se3/InSe heterostructures.
The DREB A-5 Transcription Factor ScDREB5 From Syntrichia caninervis Enhanced Salt Tolerance by Regulating Jasmonic Acid Biosynthesis in Transgenic Arabidopsis
Authors: Liu Jinyuan , Yang Ruirui , Liang Yuqing , Wang Yan , Li Xiaoshuang
Published: April 2022

Salinity is a major limiting factor in crop productivity. Dehydration-responsive element-binding protein (DREB) transcription factors have been widely identified in a variety of plants and play important roles in plant stress responses. Studies on DREBs have primarily focused on the A-1 and A-2 DREB groups, while few have focused on the A-5 group. In this study, we concentrated on ScDREB5, an A-5b type DREB gene from the desiccation-tolerant moss Syntrichia caninervis. ScDREB5 is a transcription factor localized to the nucleus that exhibits transactivation activity in yeast. Ectopic ScDREB5 expression in Arabidopsis thaliana increased seed germination and improved seedling tolerance under salt stress. ScDREB5-overexpression transgenic Arabidopsis lines showed lower methane dicarboxylic aldehyde (MDA) and hydrogen peroxide (H2O2) contents, but higher peroxidase (POD), superoxide dismutase (SOD), and catalase (CAT) activities compared to wild plants. Moreover, the transcriptional levels of stress marker genes, including RD29B, COR47, LEA6, LEA7, ERD1, P5CS1, and salt overly sensitive (SOS) genes (SOS1, SOS2, and SOS3), were upregulated in the transgenic lines when subjected to salt treatment. Transcriptome and real-time quantitative PCR (RT-qPCR) analyses indicated that transgenic lines were accompanied by an increased expression of jasmonic acid (JA) biosynthesis genes, as well as a higher JA content under salt stress. Our results suggest that ScDREB5 could improve salt tolerance by enhancing the scavenging abilities of reactive oxygen species (ROS), increasing JA content by upregulating JA synthesis gene expression, regulating ion homeostasis by up-regulating stress-related genes, osmotic adjustment, and protein protection, making ScDREB5 a promising candidate gene for crop salt stress breeding.
Artificial Intelligence-Based Human–Computer Interaction Technology Applied in Consumer Behavior Analysis and Experiential Education
Authors: Li Yanmin , Zhong Ziqi , Zhang Fengrui , Zhao Xinjie
Published: April 2022

In the course of consumer behavior, it is necessary to study the relationship between the characteristics of psychological activities and the laws of behavior when consumers acquire and use products or services. With the development of the Internet and mobile terminals, electronic commerce (E-commerce) has become an important form of consumption for people. In order to conduct experiential education in E-commerce combined with consumer behavior, courses to understand consumer satisfaction. From the perspective of E-commerce companies, this study proposes to use artificial intelligence (AI) image recognition technology to recognize and analyze consumer facial expressions. First, it analyzes the way of human–computer interaction (HCI) in the context of E-commerce and obtains consumer satisfaction with the product through HCI technology. Then, a deep neural network (DNN) is used to predict the psychological behavior and consumer psychology of consumers to realize personalized product recommendations. In the course education of consumer behavior, it helps to understand consumer satisfaction and make a reasonable design. The experimental results show that consumers are highly satisfied with the products recommended by the system, and the degree of sanctification reaches 93.2%. It is found that the DNN model can learn consumer behavior rules during evaluation, and its prediction effect is increased by 10% compared with the traditional model, which confirms the effectiveness of the recommendation system under the DNN model. This study provides a reference for consumer psychological behavior analysis based on HCI in the context of AI, which is of great significance to help understand consumer satisfaction in consumer behavior education in the context of E-commerce.
Women as Agents of Change: Exploring Women Leaders’ Resistance and Shaping of Gender Ideologies in Pakistan
Authors: Chaudhary Nabiha , Dutt Anjali
Published: April 2022

Despite a growing focus on processes to promote gender equity, women remain significantly underrepresented in leadership positions in the Global South. In the present study we focus on the role of familial experiences in shaping and contesting gender ideologies of Pakistani women in the workplace. We specifically examine the reciprocal ways in which women leaders and their family members shape each other’s gender ideologies regarding the workplace. Data collected and analyzed for this study were semi-structured interviews with eight women in positions of leadership in Lahore, Pakistan, and interviews with one family members of each of the women leaders (thus 16 interviews total). Using thematic narrative analysis, we identified three thematic phases: learning gender expectations, resistance, and familial transformation. These phases reflect the progression of developing, resisting, and influencing individual and familial gender ideologies. We document the manifestation of these phases in three specific domains: education, marriage and motherhood, and the workplace. We then discuss how these findings contribute to understanding the experiences of women leaders and perceptions of their family members regarding women’s role in the workplace. Findings from our research provide novel insights into the ways globalization and capitalism continue to shape the socio-cultural context for women leaders in the Global South.
Does Tourism Induce Sustainable Human Capital Development in BRICS Through the Channel of Capital Formation and Financial Development? Evidence From Augmented ARDL With Structural Break and Fourier-TY Causality
Authors: Li Jun , Qamruzzaman Md.
Published: April 2022

The motivation of the study is to explore the nexus tourism-led sustainable human capital development (HCD) in Brazil, Russia, India, China, and South Africa (BRICS) for the period 1984–2019. The study applied several econometrical techniques for exposing the empirical association between tourism and HCD, such as the conventional and structural break unit root test, the combined cointegration test, long-run and short-run coefficients detected through implementing the Augmented Autoregressive Distributed Lagged (AARDL), and directional causality by following Toda-Yamamoto with Fourier function. The unit-roots test established variables are integrated in mixed order, wherein variables are stationary at a level or after the first difference. The estimated test statistics from the combined cointegration test and AARDL confirmed the long-run association between tourism, gross capital formation, financial development, and HCD. Tourism revealed a positive and statistically significant tie with HCD in the long run. Moreover, the joint effects of interactive terms TOR*GCF and TOR*FD (TOR, GCF, and FD denoting tourism development, gross capital formation, and financial development, respectively) established a positive and statistically significant relationship with HCD. In addition, the causality test revealed the feedback hypothesis available between tourism and HCD in all sample countries except India. In conclusion, the role of tourism development is critically important for sustainable HCD in BRICS. Therefore, in case of a policymaking concern, it is inevitable to address the tourism issues with care for capitalizing on the benefits for tourism development.
The Relationship Between Feedback Quality, Perceived Organizational Support, and Sense of Belongingness Among Conscientious Teleworkers
Authors: Liu Yanyan , Xu Nan , Yuan Qinghong , Liu Zhaoyan , Tian Zehui
Published: April 2022

The belongingness literature has largely examined the antecedents of non-teleworkers’ sense of belongingness, but little attention has been paid to what job-related factors could affect teleworkers’ sense of belongingness. Grounded in organizational support theory, our research focuses on why feedback quality from the direct leader brings sense of belongingness and considers how conscientiousness of teleworkers shapes this effect. Based on data from 329 participants obtained at three different time points from one technology service organization in China, our results indicated that teleworkers’ perceived organizational support serves as an essential mediator of the positive relationship between feedback quality from the direct leader and sense of belongingness. Additionally, the teleworkers’ conscientiousness strengthened the positive direct effect of feedback quality on perceived organizational support and the indirect effect on sense of belongingness. The moderating role of conscientiousness in strengthening the link between feedback quality and perceived organizational support was significant for high levels of conscientiousness and not significant for low levels. Finally, we discussed theoretical and practical implications.
Are Student Teachers’ Overall Expected Emotions Regarding Their Future Life as a Teacher Biased Toward Their Expected Peak Emotions?
Authors: Forster Markus , Kuhbandner Christof
Published: April 2022

Having functional expected emotions regarding one’s future life as a teacher is important for student teachers to maintain their motivation to choose a career as a teacher. However, humans show several biases when judging their emotional experiences. One famous bias is the so-called peak-end effect which describes the phenomenon that overall affective judgments do not reflect the average of the involved emotional experiences but the most intense and the most recent of the involved emotional experiences. Regarding student teachers’ expected positive emotions, such a bias would be functional since their motivation to become a teacher is enhanced. However, regarding student teachers’ expected negative emotions, such a bias would be dysfunctional since their motivation to become a teacher would be decreased. The aim of the present preregistered study was to examine whether student teachers’ expected future teaching-related emotions show a peak-end effect. Student teachers viewed 14 common events that could part of a typical everyday routine of a teacher and rated their expected emotional pleasure and discomfort for each of the events. Afterward, they were asked to rate their overall expected emotional pleasure and discomfort when looking at their future professional life as a whole. Results showed that expected pleasure was much larger than expected discomfort regarding both overall, peak, and average ratings. No peak-end effect was observed for overall expected discomfort which reflected the average expected discomfort across events. By contrast, overall expected pleasure was biased toward expected peak pleasure experiences. These findings indicate that student teachers judge their expected overall affect in a functional way: realistically when dealing with negative emotions but through rose-colored glasses when dealing with positive emotions.
A Comparative Analysis of the Effects of Objective and Self-Assessed Financial Literacy on Stock Investment Return
Authors: Liao Kaicheng , Zhang Yuchen , Lei Hanyun , Peng Geng , Kong Wei
Published: April 2022

Till now, comprehensive and quantitatively meaningful analyses of stock market participation outcomes of retail investors have been limited by data sources in developing countries. This article devised a special questionnaire related to stock investment to measure the financial literacy (FL) and stock investment return (SIR) for the subjects with stockownership in China and to theoretically and empirically study the effects of objective FL, self-assessed FL, and their composite FL on SIR. The results of the comparative analysis showed that self-assessed FL has a greater effect on SIR than objective FL, and the effect is mediated by risk preference. In addition, we found that competent and overconfident respondents have higher SIR, while under confident respondents cannot gain from the stock market. We also found that risk preference has a positive mediating effect in the relationship between competence and overconfidence and SIR, and a negative mediating effect in the relationship between under confidence and SIR. We thus concluded that confident investors can gain more stockholding returns via taking more risks regardless of the level of their actual financial knowledge. Our findings would be a meaningful complement to the studies of stock market participation.
How Does Inequality Affect the Residents’ Subjective Well-Being: Inequality of Opportunity and Inequality of Effort
Authors: He Qizhi , Tong Hao , Liu Jia-Bao
Published: April 2022

Based on the Chinese General Social Survey database (2010–2015), this article explores the relationship between income inequality and residents’ subjective well-being from the perspective of inequality of opportunity and inequality of effort. We find that inequality of opportunity has a negative impact on subjective well-being in China, where inequality of effort has a positive impact. Our empirical results are robust for changing the inequality indicators. In the sub-sample studies, consistent conclusions are obtained in rural areas, whereas in urban areas only inequality of effort has a significant impact. The results of mechanism study show that inequality of opportunity decreases residents’ sense of fairness, and inequality of effort increases residents’ sense of fairness, thus affecting their subjective well-being. The results of this study provide a good response to the inconclusive research findings on the impact of income inequality on subjective well-being.
Correlation of Motor Competence and Social-Emotional Wellbeing in Preschool Children
Authors: Salaj Sanja , Masnjak Mia
Published: April 2022

Introduction

The relations of motor skills to different developmental domains, i.e., cognitive, emotional, and social domain, are well-documented in research on children with poor motor competence and children with disabilities. Less conclusive evidence on interaction of motor and social or emotional development can be seen in research on typically developing children. The purpose of this study was to determine a correlation between motor skills and social-emotional functioning in typically developing preschool children and to identify differences in social-emotional functioning in children with different levels of motor competence.

Methods

A total of 125 preschool children (67 boys, 58 girls, average age 5.1 years) participated in this study. To assess children’s motor skills, we used the Test of Gross Motor Development–Second Edition that measures locomotor and object-control skills. To screen child’s social and emotional functioning, we used the Ages and Stages Questionnaire–Social Emotional: Second Edition. Spearman’s correlation analysis was used to determine association between motor skills and social-emotional functioning. Difference in social-emotional functioning between groups of preschool children with High and Low motor competences was calculated using Mann-Whitney U-test.

Results

The main result of this study is weak correlation of child’s motor skills to social-emotional functioning. Furthermore, preschool children with High and Low motor competences do not differ in risk for social and emotional difficulties.

Conclusion

Further research on typically developing children is needed to have more conclusive evidence on interaction of motor and social or emotional development.
Embodied Intelligence: Smooth Coping in the Learning Intelligent Decision Agent Cognitive Architecture
Authors: Kronsted Christian , Kugele Sean , Neemeh Zachariah A. , Ryan Kevin J. , Franklin Stan
Published: April 2022

Much of our everyday, embodied action comes in the form of smooth coping. Smooth coping is skillful action that has become habituated and ingrained, generally placing less stress on cognitive load than considered and deliberative thought and action. When performed with skill and expertise, walking, driving, skiing, musical performances, and short-order cooking are all examples of the phenomenon. Smooth coping is characterized by its rapidity and relative lack of reflection, both being hallmarks of automatization. Deliberative and reflective actions provide the contrast case. In Dreyfus’ classic view, smooth coping is “mindless” absorption into action, being in the flow, and any reflective thought will only interrupt this flow. Building on the pragmatist account of Dewey, others, such as Sutton, Montero, and Gallagher, insist on the intelligent flexibility built into smooth coping, suggesting that it is not equivalent to automatization. We seek to answer two complementary challenges in this article. First, how might we model smooth coping in autonomous agents (natural or artificial) at fine granularity? Second, we use this model of smooth coping to show how we might implement smooth coping in artificial intelligent agents. We develop a conceptual model of smooth coping in LIDA (Learning Intelligent Decision Agent). LIDA is an embodied cognitive architecture implementing the global workspace theory of consciousness, among other psychological theories. LIDA’s implementation of consciousness enables us to account for the phenomenology of smooth coping, something that few cognitive architectures would be able to do. Through the fine granular analysis of LIDA, we argue that smooth coping is a sequence of automatized actions intermittently interspersed with consciously mediated action selection, supplemented by dorsal stream processes. In other words, non-conscious, automatized actions (whether learned or innate) often require occasional bursts of conscious cognition to achieve the skillful and flexible adjustments of smooth coping. In addition, never-conscious dorsal stream information and associated sensorimotor processes provide further online adjustments during smooth coping. To achieve smooth coping in LIDA we introduce a new module to the LIDA cognitive architecture the Automatized Action Selection sub-module. Our complex model of smooth coping borrows notions of “embodied intelligence” from enactivism and augments these by allowing representations and more detailed mechanisms of conscious control. We explore several extended examples of smooth coping, starting from basic activities like walking and scaling up to more complex tasks like driving and short-order cooking.
Individual Strategies of Response Organization in Multitasking Are Stable Even at Risk of High Between-Task Interference
Authors: Reinert Roman , Brüning Jovita
Published: April 2022

Recently, reliable interindividual differences were found for the way how individuals process multiple tasks (at a cognitive level) and how they organize their responses (at a response level). Previous studies have shown mixed results with respect to the flexibility of these preferences. On the one hand, individuals tend to adjust their preferred task processing mode to varying degrees of risk of crosstalk between tasks. On the other, response strategies were observed to be highly stable under varying between-resource competition. In the present study, we investigated whether the stability of response strategies also persists with increased risk of crosstalk or whether individuals adjust their choice of response strategy, similar to what has been found at the level of task processing modes. Besides, related differences in multitasking efficiency were assessed. For this purpose, 53 participants performed the Free Concurrent Dual-Tasking (FCDT) paradigm, which allows them to control their task scheduling and response organization. The participants completed the FCDT paradigm under two conditions including task pairs characterized by either low or high levels of risk of crosstalk. The free choice of task scheduling resulted in the previously found distinct response patterns, best described as blocking, switching or response grouping. Remarkably, we did not find any notable adjustments of strategies of response organization to the extent of crosstalk. However, we observed suspected performance decrements of a switching strategy in the condition of high risk of crosstalk. The results suggest that individual strategies of response organization are stable habits. Further, they illustrate disadvantages of switching vs. blocking strategies of response organization in case of high task similarity.
From Silence to Speaking Up About Sexual Violence in Greece: Olympic Journeys in a Culture That Neglects Safety
Authors: Chroni Stiliani “Ani” , Kavoura Anna
Published: April 2022

The present study scrutinizes the role of societal culture in cases of sexual violence in Greek sport, as presented in the media after a two times Olympic medalist of Greece fired up the “‘me too’ Movement” in the country. Specifically, data for this study consisted of 36 media articles (14 international in the English language and 22 national in the Greek language), reporting multiple cases of sexual abuse and harassment in Greek sport and were published between January 2021 and January 2022. We drew on the cultural praxis heuristic to explore how the cultural setting operates as an underlying factor in priming athletes for harassment and abuse and in oppressing them into not speaking up. Our thematic analysis of media data revealed two overarching themes, namely,keeping the home intactandfailed negotiations with power. Based on these findings, we discuss how subtle manifestations of patriarchy and collectivism perpetuate sexualized violence in Greek sport as they promote a climate of silence, prevent safeguarding, maintain underreporting of sexual violence, and delayed the arrival of the #metoo. We conclude that under the current circumstances, change seems to be a threat to all involved in Greek sport, yet for different reasons. For the coaches, sport officials, stakeholders, state system, change would require them to relinquish male powers and authority, find new meaning of what it means to be and do as a man, and allow women to be seen as counterparts. For the female athletes-survivors, it would require them to prioritize the self and their self-care and let go of the in-group loyalty and subordination learned and exhibited from infancy. We also contend that mere translations of international and regional safeguarding guidelines and toolkits cannot foster awareness raising, nor the implementation of measures within cultural settings that divert from the Global North. If we care to combat the universal phenomenon of sexualized violence in sport, a glocal approach is needed, where local socio-cultural factors are acknowledged, their role is addressed, and violence is understood within its context.
Are There Neural Overlaps of Reactivity to Illegal Drugs, Tobacco, and Alcohol Cues? With Evidence From ALE and CMA
Authors: Li HuiLing , Zhao Dong , Liu YuQing , Xv JingWen , Huang HanZhi , Jin Yutong , Lu Yiying , Qi YuanYuan , Zhou Qiang
Published: April 2022

Abuses of most illegal drugs, including methamphetamine, marijuana, cocaine, heroin, and polydrug, are usually in conjunction with alcohol and tobacco. There are similarities and associations between the behavior, gene, and neurophysiology of such abusers, but the neural overlaps of their cue-reactivity and the correlation of neural overlap with drug craving still needs to be further explored. In this study, an Activation Likelihood Estimation (ALE) was performed on brain activation under legal (tobacco, alcohol) and illegal drug cues, for identifying the similarities in brain functions between different craving states. A Comprehensive meta-analysis (CMA) on the correlation coefficient between brain activation and craving scores in the selected literatures with subjective craving reports explained the degree of the craving via brain imaging results. In ALE, co-activation areas of the three cue-reactivity (posterior cingulate, caudate, and thalamus) suggest that the three cue-reactivity may all arouse drug-use identity which is a predictor of relapse and generation of conditioned reflexes under reward memory, thus leading to illegal drug relapses. In CMA, the brain activation was significantly correlated with subjective craving, with a correlation coefficient of 0.222. The neural overlap of tobacco, alcohol and most of the prevalent illegal drug cues not only further helps us understand the neural mechanism of substance co-abuse and relapse, but also provides implications to detoxification. Furthermore, the correlation between brain activation and craving is low, suggesting the accuracy of craving-based quantitative evaluation by neuroimaging remains unclear.
Postpartum Diet and the Lifestyle of Korean and Chinese Women: A Comparative Study
Authors: Li Jia , Gray Heewon L. , Kim Sohyun , Park Haeryun , Lee Youngmi , Lee Hongmie , Song Kyunghee
Published: April 2022

Objective

The study investigated and compared postpartum diet and behaviors, nutrition education, and psychological health status among Korean and Chinese postpartum women (0–6 months after delivery).

Methods

A total of 221 Korean mothers in Gyeonggi-do (South Korea) and 221 mothers in Jinhua (China) participated in the survey between November and December 2018, and the results were statistically analyzed using the SPSS Statistics 25.0 software.

Results

Many postpartum behaviors, such as postpartum diet pattern and care duration differed between Korean and Chinese mothers. The former showed a stronger desire for nutrition education compared with the latter (p < 0.001). Korean mothers' life and meal satisfaction, and contentment with their husband's support were all ~0.5 points higher compared with Chinese mothers, particularly regarding spousal support (p < 0.001). Postpartum depression stresses positively correlated with postpartum infant care stress and negatively correlated with life satisfaction. In addition, primipara mothers were more in need of infant care support and guidance concerning appropriate baby-feeding techniques compared with multipara mothers.

Conclusion

Traditional culture was a crucial factor that influenced the perceptions of postpartum women in South Korea and China. Culturally tailored nutrition education and exercise programs may benefit Korean and Chinese women after childbirth.
The Food Environment Around Primary Schools in a Diverse Urban Area in the Netherlands: Linking Fast-Food Density and Proximity to Neighbourhood Disadvantage and Childhood Overweight Prevalence
Authors: Smagge Bente A. , van der Velde Laura A. , Kiefte-de Jong Jessica C.
Published: April 2022

In the Netherlands, the neighbourhood food environment has received little attention in initiatives to combat overweight/obesity. This study maps the food environment around primary schools in The Hague, The Netherlands, and examines associations between neighbourhood disadvantage, the school food environment and childhood overweight using Geographic Information Systems (GIS). Linear regression analyses were performed to test the association between schools' disadvantage scores (proxy for neighbourhood disadvantage) and relative fast-food density within 400 m and 1000 m and fast-food proximity. Univariable and multivariable linear regression analyses were used to test the association between the school food environment and overweight prevalence among children in the respective sub-district in which the schools is found. Multivariable analyses were adjusted for the schools' disadvantage scores. Results show that fast-food outlets were available around most primary schools. Schools in disadvantaged neighbourhoods were closer to and surrounded by a higher number of fast-food restaurants, grillrooms and kebab shops. On the sub-district level, the density of such fast-food outlets was associated with overweight prevalence among children. These findings highlight the importance of national and local policies to improve the food environment, particularly in disadvantaged neighbourhoods.
General Practitioner Time Availability Per Inhabitant Per Year: A New Indicator to Measure Access to Primary Care
Authors: Beer Laura , Cohidon Christine , Senn Nicolas
Published: April 2022

Introduction

The number of general practitioners (GPs) per inhabitant, used commonly as an indicator of primary care (PC) access, reports only imprecisely on the true availability of GPs. The aim of this study is to develop a new PC access indicator that better reflects the availability of GPs to take care of patients at the population level, the average GP time availability per inhabitant per year.

Methods

We extracted the data from the Commonwealth Fund International Health Policy Survey of Primary Care Physicians conducted in 2015, including 11 Western countries and 12,049 randomly drawn GPs. We built the indicator by combining two questions about weekly workload in hours and percentage of time spent on face-to-face contact with patients. The indicator was then adjusted regarding the number of GPs, the weeks worked per year and the country's population size.

Results

On average, GPs worked 43 h a week. The average time spent on face-to-face contact with patients was 30.5 h/week (35 h including emails and telephone contact), ranging from 22 h in Sweden and 38 h in France. The mean time available of GPs for face-to-face contact was 69 min/inhabitant/year, ranging from 38 min in Sweden to 118 min in Australia. Including email and telephone contact, the mean contact time rose to 79 min/inhabitant/year, ranging from 48 min in Sweden to 127 min in Australia.

Conclusion

The new indicator provides an accurate and sensitive estimate of a GP's true time availability at the population level. Results should be interpreted in the context of PC workforce organization, which may help guide GP workforce development.
Active Inference and Epistemic Value in Graphical Models
Authors: van de Laar Thijs , Koudahl Magnus , van Erp Bart , de Vries Bert
Published: April 2022

The Free Energy Principle (FEP) postulates that biological agents perceive and interact with their environment in order to minimize a Variational Free Energy (VFE) with respect to a generative model of their environment. The inference of a policy (future control sequence) according to the FEP is known as Active Inference (AIF). The AIF literature describes multiple VFE objectives for policy planning that lead to epistemic (information-seeking) behavior. However, most objectives have limited modeling flexibility. This paper approaches epistemic behavior from a constrained Bethe Free Energy (CBFE) perspective. Crucially, variational optimization of the CBFE can be expressed in terms of message passing on free-form generative models. The key intuition behind the CBFE is that we impose a point-mass constraint on predicted outcomes, which explicitly encodes the assumption that the agent will make observations in the future. We interpret the CBFE objective in terms of its constituent behavioral drives. We then illustrate resulting behavior of the CBFE by planning and interacting with a simulated T-maze environment. Simulations for the T-maze task illustrate how the CBFE agent exhibits an epistemic drive, and actively plans ahead to account for the impact of predicted outcomes. Compared to an EFE agent, the CBFE agent incurs expected reward in significantly more environmental scenarios. We conclude that CBFE optimization by message passing suggests a general mechanism for epistemic-aware AIF in free-form generative models.
Contamination and Removal Efficiency of Microplastics and Synthetic Fibres in a Conventional Drinking Water Treatment Plant
Authors: Negrete Velasco Angel , Ramseier Gentile Stéphan , Zimmermann Stéphane , Stoll Serge
Published: April 2022

Microplastics have been detected all around the globe in freshwaters which are frequently used to produce drinking water. Therefore, the contamination of raw water with microplastics that supplies drinking water treatment plants, and their removal efficiency is raising more concern and interest. In the present study, we evaluated the microplastic contamination in a conventional drinking water treatment plant (Geneva, Switzerland) and the contribution of coagulation on the efficiency of the filtration systems (sand and activated carbon filtrations) in the removal efficiency of microplastics (MPs) and synthetic fibres. This work was performed in a pilot station that replicates the main drinking water treatment process. Raw water and effluents of each filtering processes were analysed for the presence of MPs and synthetic fibres with sizes ≥ 63 μm using infrared spectroscopy. The contamination of MPs in raw water and in drinking water ranged from 19.5 to 143.5 MPs/m3 and from 0 to 8 MPs/m3 (in presence and absence of coagulant), respectively. On the other hand, concentration of synthetic fibres ranged from 7.7 to 23.8 synthetic fibres/m3 in raw water and from 0 to 3 synthetic fibres/m3 in drinking water. Results show that on average 89% of microplastics and 81% of synthetic fibres (≥63 μm) are retained in water treatment in absence of coagulant. Better final removal efficiency of microplastics (97%) and synthetic fibres (96%) was observed in drinking water with coagulation treatment. The chemical composition of microplastics and synthetic fibres is found more heterogeneous in raw water than after sand filtration and activated carbon filtration.
How to See Pressure in Sport as a Challenge, Not a Threat
Authors: Meijen Carla , Turner Martin J. , Jones Marc V.
Published: April 2022

Playing sport is fun. But we can also get nervous about it. Many people competing in sports get nervous and feel pressure because doing their best is important to them. Feeling pressure is not automatically bad. If you see pressure as a positive challenge, it can help you do your best. However, seeing pressure as a negative threat can stop you from doing your best. Why? When you see pressure as something positive (a challenge), you believe in your abilities, feel in control of your situation, and are focused on facing the situation head-on. When you see pressure as a challenge, you might feel nervous, but you know this feeling helps you do your best, which helps your body respond in a helpful way. How can you make sure you see pressure as a challenge? One way is using techniques to help you to face pressure head-on, with self-belief, control, and excitement.
Caffeine Supplementation Strategies Among Endurance Athletes
Authors: Kreutzer Andreas , Graybeal Austin J. , Moss Kamiah , Braun-Trocchio Robyn , Shah Meena
Published: April 2022

Caffeine is widely accepted as an endurance-performance enhancing supplement. Most scientific research studies use doses of 3–6 mg/kg of caffeine 60 min prior to exercise based on pharmacokinetics. It is not well understood whether endurance athletes employ similar supplementation strategies in practice. The purpose of this study was to investigate caffeine supplementation protocols among endurance athletes. A survey conducted on Qualtrics returned responses regarding caffeine supplementation from 254 endurance athletes (f = 134, m =120; age = 39.4 ± 13.9 y; pro = 11, current collegiate athlete = 37, recreational = 206; running = 98, triathlon = 83, cycling = 54, other = 19; training days per week = 5.4 ± 1.3). Most participants reported habitual caffeine consumption (85.0%; 41.2% multiple times daily). However, only 24.0% used caffeine supplements. A greater proportion of men (31.7%) used caffeine supplements compared with women (17.2%; p = 0.007). Caffeine use was also more prevalent among professional (45.5%) and recreational athletes (25.1%) than in collegiate athletes (9.4%). Type of sport (p = 0.641), household income (p = 0.263), education (p = 0.570) or working with a coach (p = 0.612) did not have an impact on caffeine supplementation prevalence. Of those reporting specific timing of caffeine supplementation, 49.1% and 34.9% reported consuming caffeine within 30 min of training and races respectively; 38.6 and 36.5% used caffeine 30–60 min before training and races. Recreational athletes reported consuming smaller amounts of caffeine before training (1.6 ± 1.0 mg/kg) and races (2.0 ± 1.2 mg/kg) compared with collegiate (TRG: 2.1 ± 1.2 mg/kg; RACE: 3.6 ± 0.2 mg/kg) and professional (TRG: 2.4 ± 1.1 mg/kg; RACE: 3.5 ± 0.6 mg/kg) athletes. Overall, participants reported minor to moderate perceived effectiveness of caffeine supplementation (2.31 ± 0.9 on a four-point Likert-type scale) with greatest effectiveness during longer sessions (2.8 ± 1.1). It appears that recreational athletes use lower caffeine amounts than what has been established as ergogenic in laboratory protocols; further, they consume caffeine closer to exercise compared with typical research protocols. Thus, better education of recreational athletes and additional research into alternative supplementation strategies are warranted.
Kinematics of the Final Approach and Take-Off Phases in World-Class Men and Women Pole Vaulters
Authors: Hanley Brian , Gravestock Helen J. , Hopkinson Mike , Paradisis Giorgos P. , Merlino Stéphane , Bissas Athanassios
Published: April 2022

The pole vault is a highly technical event where the athletes must successfully convert horizontal velocity during the run-up to vertical velocity at take-off. The aim of this study was to compare the kinematics of men's and women's world-class pole vaulting. Video data were collected of the best clearances by 14 men and 11 women at the 2018 IAAF World Indoor Championships using three high-speed cameras (200 Hz). Running velocity, step lengths, step times, and pole angles were measured during the run-up; during take-off, distance from the plant box, angle and velocity of take-off, and relative positions of the foot and hands were measured. Men achieved greater clearance heights with faster run-ups, faster take-off velocities and higher hand grip positions (all p < 0.001), with each of the last three steps longer for men when expressed as absolute values (all p < 0.001), but not when expressed relative to stature. There were no differences in run-up pole angles, step times, take-off angle, take-off contact time or time from pole plant to take-off. Women differed in their approach and take-off for characteristics affected by stature and strength, such as fewer run-up steps, shorter take-off distances, and lower grip heights. These lower grips result from a shorter, lighter pole, and this disadvantage was greater than slower run-up velocities. Coaches should therefore note that sex-based differences occur in the pole vault that result from anthropometric differences, but which do not negate the adoption of similar technical models of vaulting.
Selective Hepatic Vascular Exclusion versus Pringle Maneuver in Major Hepatectomy: A Systematic Review and Meta-Analysis
Authors: Mobarak Shahd , Stott Martyn C. , Tarazi Munir , Varley Rebecca J. , Davé Madhav S. , Baltatzis Minas , Satyadas Thomas
Published: April 2022

Objectives

Mortality and morbidity following hepatic resection is significantly affected by major intra-operative blood loss. This systematic review and meta-analysis evaluates whether selective hepatic vascular exclusion (SHVE) compared to a Pringle maneuver in hepatic resection reduces rates of morbidity and mortality.

Methods

A systematic review and meta-analysis were conducted according to the PRISMA guidelines by screening EMBASE, MEDLINE/PubMed, CENTRAL and SCOPUS for comparative studies meeting the inclusion criteria. Pooled odds ratios or mean differences were calculated for outcomes using either fixed- or random-effects models.

Results

Six studies were identified: three randomised controlled trials and three observational studies reporting a total of 2,238 patients. Data synthesis showed significantly decreased rates of mortality, overall complications, blood loss, transfusion requirements, air embolism, liver failure and multi-organ failure in the SHVE group. Rates of hepatic vein rupture, post-operative hemorrhage, operative and warm ischemia time, length of stay in hospital and intensive care unit were not statistically significant between the two groups.

Conclusion

Performing SHVE in major hepatectomy may result in reduced rates of morbidity and mortality when compared to a Pringle maneuver. The results of this meta-analysis are based on studies where tumors were adjacent to major vessels. Further RCTs are required to validate these results.

Clinical Trial Registration

PROSPERO (CRD42020212372) https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=212372.