bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis histórico de la precipitación en Felipe Carrillo Puerto
Authors: Dra Mercedes  , Vargas-Magaña María Fernanda
Published: January 2024

El presente trabajo versa en un análisis de la precipitación histórica en el periodo de 1972 2012 de las estaciones FELIPE CARRILLO PUERTO (DGE) – QROO, X PICHIL QROO y SEÑOR QROO del Servicio Meteorológico Nacional en el Estado de Quintana Roo para determinar los even tos secos y húmedos del poblado Felipe Carrillo Puerto. Se definieron áreas de polígonos circun dantes a las estaciones mediante diagramas de Voronoi y se calculó el índice estandarizado de precipitación (SPI) para la precipitación reportada por cada estación. Se encontró que hay cambios de los patrones de precipitación entre las estaciones que pueden responder a factores geográficos de la zona. Se propuso el cálculo del SPI mediante un factor areal en la zona de estudio. Los re sultados muestran que el factor areal no cambia los eventos húmedos y secos de la zona, lo cual nos permite contar con una distribución de la precipitación en el área cercana a la estación. Los patrones de precipitación muestran para la zona de estudio mayores eventos secos para los últimos años del registro, es decir eventos de sequía en la zona.
Comparative analysis of the availability and satisfaction of patients with acne with medical assistance in various healthcare facilities
Authors: Golikova L. O. , Antonenkov Yu. E.
Published: January 2024

Accessibility and satisfaction with the quality of care for patients with acne are relevant, including in Russia. Therefore, Voronezh Oblast, being one of the largest in the Central Federal District, is able to present these indicators for the whole of Russia. The aim was to compare the accessibility and satisfaction of patients with acne with medical assistance in various healthcare facilities through a survey. The results obtained during the work revealed significant problems in this area and created opportunities for overcoming them.
Assessment of criteria influencing the location of healthcare facilities in small and hard-to-reach areas
Authors: Deev I. A. , Polikarpov A. V. , Golubev N. A. , Moravskaya S. V. , Kobyakova O. S.
Published: January 2024

Aim. To identify and systematize the criteria influencing the location of healthcare facilities in small and hard-to-reach areas.

Material and methods. Within the study, regulatory legal acts of the Russian Federation and methodological guidelines on territorial planning were analyzed. Content analysis and statistical methods were used.

Results. The following criteria for a comprehensive assessment of the location of healthcare facilities should be used: 1. Age structure of the population. 2. Distance to a similar medical organization. 3. Population size within the working radius of the organization. 4. Availability of public roads (criteria and categories of roads). 5. Availability of public transport. 6. Climatic. 7. Availability of medical workers residing in the locality. 8. Availability of mobile medical teams. 9. Dilapidation and breakdown of buildings. Taking into account various criteria affecting the accessibility of primary health care to a patient, it is possible to develop and implement management decisions on the rational placement of healthcare facilities at the regional level with detail for each locality.

Conclusion. The use of criteria in territorial planning for a comprehensive assessment of the location of healthcare facilities makes it possible to take into account regional climatic, geographic, infrastructural, social and other features of the Russian constituent entities. This contributes to the implementation of development targets for primary health care in small and hard-to-reach areas.
Cognitive-matrix analysis of research on primary health care development in the Russian Federation for the period from 2012 to 2022
Authors: Orlov S. A. , Shepel R. N. , Voshev D. V. , Savchenko D. O. , Gellekh D. A. , Gorlov А. B. , Mezhidov K. S. , Turlay M. V. , Sentsova A. V. , Zhamalov L. M. , Kontsevaya A. V. , Drapkina O. M.
Published: January 2024

The distribution of publications posted in the Elibrary for the period from January 1, 2012 to December 31, 2022, in the structure of a cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation made it possible to establish areas of scientific interest and identify gaps in specific areas and indicators characterizing its current and future development.

Aim. To distribute scientific publications according to the relevant segments of the cognitive matrix of taxonomic characteristics for the analysis and assessment of primary health care in the Russian Federation.

Material and methods. A database of 41824 publications was used, for which a triple review was carried out with the involvement of 9 experts selected according to appropriate criteria for level of education, work experience in the healthcare system, and academic credentials. At the first two stages, publications not related to primary health care, as well as duplicate publications, were excluded. At the final stage of reviewing, a selective analysis of publications was carried out, assessing the correctness of their distribution into the corresponding taxa of the cognitive matrix, followed by adjustment (if necessary).

Results. A cognitive matrix of taxonomic characteristics has been generated for the analysis and assessment of primary health care in the Russian Federation, containing 30339 publications distributed across relevant domains, subdomains and primary health care indicators. The matrix is also presented in a heat map format, allowing an assessment of the most studied taxa of primary health care, as well as highlighting those areas in primary health care in which more research should be carried out to provide a basis and methodology for making informed decisions on its development.

Conclusion. Systematized and ordered publications can serve as a basis for a wide range of users in the preparation of systematic reviews and other publications on specific domains, subdomains, primary health care indicators and universal health coverage principles. This study has shown the high efficiency of the cognitive matrix of taxonomic characteristics as a unified tool for aggregation or decomposition of features characterizing the development of primary health care in the Russian Federation.
FIELD EXPERIMENTAL INVESTIGATION OF THE INSULATION DETERIORATION CHARACTERISTICS OF OVERHEAD PIPELINE FOR STEAM HEATING NETWORK
Authors: Lin Junguang , Zhao Jianfa , Wang Xiaotian , Chen Kailun , Zhang Liang
Published: January 2024

The thermal insulation performance of pipeline is significant for the safety and economical operation of
vapor steam network. In order to investigate the long-time insulation performance of pipeline, a field test was carried out in pipelines of 12 different heating networks with the operating time ranging from 1 to 11 years. Two different types of insulation coating layer were included. The total heat flux and surface heat flux in a pipeline were measured to obtain the equivalent thermal conductivity of the insulation coating layer, and a deterioration coefficient was applied to analyze the insulation deterioration characteristics. The results show that the one-dimensional thermal conduction method is feasible to calculate the heat flux of the pre-manufactured pipeline with hard insulation materials, and an error less than 2% for pipeline 1 was obtained. Further, a proper size of slip in the insulation coating layer has improved the insulation performance by 13.6% in pipeline 2. For the soft type insulation coating, the structure has been changed under the long-term effect of gravity. Accordingly, a single thermal conductivity cannot accurately characterize the heat transfer process within the insulation layer. The surface heat flux accounts for less than 30% of the total heat loss. The insulation deterioration trend with operating time cannot exactly be obtained by the surface heat flux. In addition to the thickness reduction at the top and hollow at the bottom, the convection heat leakage from the gaps should also be a concern for long time operation.
BLENDING HYDROGEN WITH LPG AND METHANE IN PREMIXED AND STRATIFIED FLAMES: AN EXPERIMENTAL STUDY
Authors: Sellan Dhanalakshmi , Pillai Sidharth K. , Murugan Raju , Balusamy Saravanan
Published: January 2024

This experimental work investigates the effects of blending hydrogen into liquefied petroleum gas (LPG)/air flames and methane/air flames under different stratified mixture conditions. A laboratory scale, a swirl-stabilized burner with two annular tubes, is used to examine the stability and structure of the flames. Fully premixed fuel-air mixture are provided through an inner and outer annulus, with equivalency ratios of φ1 and φ2. Two experimental scenarios are studied to understand the hydrogen blending by mass. In the first scenario, hydrogen was introduced to replace LPG in the inner stream, while in the second scenario, hydrogen replaced LPG in the outer stream. The second scenario involves optimizing the operating conditions of the burner to achieve flame stabilization with a hydrogen blend of up to 90%. The study employs direct flame imaging and simultaneously captures OH*/CH* chemiluminescence imaging. The findings reveal that in the first scenario, a flashback occurs when hydrogen replaces LPG beyond 20% in the inner stream. However, in the second scenario, no flashback is observed even when hydrogen in the outer stream replaces up to 90% of LPG. The study also reports stable flame structures for various operating conditions using chemiluminescence imaging. These results underscore the importance of fuel blending strategies and demonstrate the potential of hydrogen as a feasible alternative fuel in combustion applications.
A simplified approach for local buckling in metal-faced profiled sandwich panels
Authors: Tahir Muhammad Naeem , Hamed Ehab
Published: January 2024

Local buckling (wrinkling) is very common in metal-faced insulating sandwich panels (MFISPs) due to the small thickness of their face sheets. In some cases, wrinkling leads to sudden failures, while in others it leads to degradation of the overall stiffness and can decrease the failure load. A simplified finite-element modelling approach is presented to estimate the local buckling pressure of such panels. In the proposed approach, only the face sheet under compression is modelled, thus avoiding the need to perform a full three-dimensional (3D) structural analysis. The working assumption is that the relative deflection of the buckled face against the face under tension (unbuckled face) can be modelled using a two-parameter elastic foundation approach. The elastic foundation is simulated by closely spaced horizontal and vertical springs that model the rigidities of the foam core. Two models are used to determine the elastic foundation properties. The simplified approach was validated through comparisons with 3D analyses of full sandwich panels and available experimental results. It was found that the proposed approach can be applied to various types of MFISPs (flat or heavily profiled) with a variety of foam cores and face sheet thicknesses.
Preoperative evaluation of systolic murmur with point-of-care echocardiography before an elective thoracic surgery - A case report -
Authors: Lee Jaemoon , Lee Minki , Lee Sookyung , Oh Chung-Sik , Kim Tae-Yop
Published: January 2024

Background: Systolic murmur suggesting the association of aortic valve (AV) stenosis or obstructive pathology in the left ventricular outflow tract (LVOT) usually requires preoperative echocardiographic evaluation for elective surgery.Case: In a 63-year-old female patient undergoing elective thoracic surgery, the systolic murmur was auscultated on the right sternal border of the second intercostal space in the preoperative patient holding area. Point-of-care (POC) transthoracic echocardiography (TTE) demonstrated a systolic jet flow in the LVOT area. The peak systolic velocity of the continuous wave Doppler tracing, aligned to the LVOT and the AV, was approximately 1.5 m/s. The peak/mean pressure gradient was 11/6 mmHg for the AV and 9/5 mmHg for the LVOT. Anesthesia was induced under continuous TTE imaging. Intraoperative transesophageal echocardiography also confirmed the absence of any cardiac pathology.Conclusions: POC echocardiography offered a thorough preoperative evaluation of an unexpectedly identified systolic murmur, avoiding a potential delay in the operation schedule for conventional preoperative echocardiographic evaluation.
Improved flood quantile estimation for South Africa
Authors: D van der Spuy  , JA du Plessis
Published: January 2024

The performance of the most frequently used flood frequency probability distributions in South Africa (Log-Normal, Log Pearson3 and Generalised Extreme Value) were reviewed and all tend to perform poorly when lower exceedance probability frequency events are estimated, especially where outliers are present in the dataset. This can be attributed to the challenge when analysing very limited ‘samples’ of annual flood peak populations, which are an unknown. At present outliers are inadequately 'managed' by attempting to 'normalise' the flood peak dataset, which conceals the significance of the observed data. Thus, to adequately consider the outliers, this study was undertaken with the aim to improve the current statistical approach by developing a more stable and consistent methodology to estimate flood quantiles. The approach followed in the development of the new methodology, called IPZA, might be considered as unconventional, given that a multiple regression approach was used to accommodate the strongly skewed data, which are often associated with annual flood peak series. The main advantages of IPZA are consistency, the simplicity of application (only one set of frequency factors for every parameter, regardless of the skewness), the integrated handling of outliers and the use of conventional method of moments, thereby eliminating the need to adjust any moments. The performance of IPZA exceeded initial expectations. The results are more consistent and, by taking outliers into account, appear to be more sensible than existing probability distributions. It is recommended that IPZA should be used as a valuable addition to the existing set of decision-making tools for hydrologists/engineers performing flood frequency analyses.
Parallel rapid expression and purification of proteins for crystallography (PREPX): large scale 1 L cultures v1
Authors: not provided michael.fairhead
Published: January 2024

This protocol details the parallel rapid expression and purification of proteins for crystallography (PREPX) at a 1 L culture scale. Recombinant proteins are expressed in Escherichia coli using the autoinduction method and then purified in parallel using a IMAC, desalt, tag cleavage, reverse IMAC and gel filtration work flow.
Manifestation of linguistic aesthetics and characters in Javanese wedding ceremonial discourse
Authors: Mulyana Mulyana
Published: January 2024

This research is an exploration into a wedding ceremonial discourse (WCD) in the contexts of Javanese traditional ceremonies. In doing so, the study focuses the observation in the practices in Yogyakarta and the surrounding regions, where Javanese traditional wedding is still a norm. The data were collected in two main sources, namely the spoken discourses from the speech makers in wedding ceremonies,and written references on wedding scripts used as supplementary data. Two main features are shown as a result of the study. First, Javanese language aesthetics are manifested in the expressions of delivered by the speech makers in the wedding ceremonies, despite the use of occasional mix with Indonesian. Secondly, the use of the language in WCD also reflect the expected characters of the speech makers in the ceremonies. WCD shows dynamics of language use. Within its development, the discourse of wedding speech in the Javanese language will continue to sustain and develop under several changes with regards to the ceremonial procedures, sentence structure, diction, and language selection.
The Javanese philosophy behind the panakawan characters: An Ethnolinguistic analysis of the play Semar Mbangun Kahyangan
Authors: Widayat Afendy , Dwiadmojo Ghis Nggar
Published: January 2024

This ethnolinguistic analysis delves into the world of Panakawan characters in the Javanese play "Semar Mbangun Kahyangan," unveiling the profound tapestry of Javanese philosophy into their portrayal. The Panakawan, celebrated for their wit and linguistic artistry, stand as iconic figures in traditional Javanese wayang (shadow puppetry) and theater. This study explored their linguistic and cultural dimensions, illuminating their role as carriers of Javanese wisdom and cultural values. Employing ethnolinguistic methods, it examined the linguistic features, discourse patterns, and cultural intricacies interwoven within the dialogues and actions of the Panakawan characters. The analysis uncovers language's role in conveying Javanese philosophical concepts, moral teachings, and the interconnectedness of life and society within the play. It dissected the linguistic strategies, humor, and linguistic playfulness of the Panakawan, revealing their capacity to impart profound philosophical messages while captivating audiences. Furthermore, this study also revealed the inseparable bond between language, culture, and the embodiment of Javanese philosophy in the play "Semar Mbangun Kahyangan." It offers insights into the Panakawan's function as cultural emissaries and guardians of the Javanese ethos. This ethnolinguistic exploration extends an invitation to readers to uncover the concealed Javanese philosophy within the eloquent expressions and deeds of the Panakawan. It is expected to provide a significant contribution to ethnolinguistics, cultural studies, and philosophy by spotlighting the Panakawan characters' pivotal role as conduits for conveying the profound philosophy that shapes Javanese culture and character.
RSM based modelling and optimization of Marshall properties of steel-slag and lime-modified asphalt mixtures
Authors:   Dept. of Civil and Mining Engineering, Confluence University of Science and Technology, Daniel Oguntayo , Olumide Ogundipe ,   Civil Engineering Department, Ekiti State University, Oluwasegun Aluko ,   Civil Engineering Department, Ekiti State University, Yusuf Babatunde ,   Civil Engineering Department, University of Ilorin
Published: January 2024

Statistical and optimization techniques are useful tools in understanding the interactions and relationships between the asphalt mix variables and the contribution of each variable to the resulting asphalt mixture properties. This study explores the response surface methodology to study the influence of steel slag and lime on the Marshall properties of asphalt mixtures using Box Behnken Design tool. The independent variables considered are steel slag (0-100%), lime (0-4%) and bitumen (4-8%). The stability, flow, Marshall quotients, bulk density, Vb and VMA obtained were 1.98-6.35 kN, 3.27-4.53 mm, 0.53-1.60 kN/mm, 2.08-2.29 kg/m3, 7.67-14.7% and 14.02-24.63%, respectively; indicating that the steel-slag and lime-modified asphalt mixtures satisfy the specification limits recommended by the asphalt institute and Nigeria General Specification for Roads and Bridges. The models' analysis of variance revealed could well predict the Marshall properties of the mixtures, and the terms of steel-slag, lime and bitumen content are significant. Likewise, based on the optimization analysis, 24.93% of steel slag, 2.43% of lime and 5.51% of bitumen content were selected as the optimal values for the modified asphalt mixtures. Additionally, a mean error of less than 5% was attained for all the responses, demonstrating the effectiveness of RSM in designing asphalt mixtures.
A SAÚDE BUCAL DURANTE O PRÉ-NATAL: UMA REVISÃO INTEGRATIVA
Authors: Fernandes Barros Elton , Bandeira de Pontes Santos Hellen
Published: January 2024

O pré-natal é um conjunto de cuidados assistenciais e procedimentos clínicos para a manutenção da saúde gestacional. Sob a perspectiva da saúde oral no contexto do serviço público, que é considerado como acesso principal a esses cuidados, caracteriza-se de extrema importância devido às diversas alterações sistêmicas que resultam ou amplificam em alterações orais prejudiciais à saúde da gestante e, consequentemente, à do feto. Assim, este estudo tem como objetivo realizar uma revisão de literatura sobre o pré-natal no contexto da saúde bucal pública do Brasil, evidenciando as características e limitações. Trata-se de uma revisão de literatura que, com o auxílio de descritores, consistiu na busca de artigos em três bases de dados: Scientific Electronic Library Online (SciELO), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e PubMed. Nos estudos analisados, percebeu-se que fatores socioeconômicos, hábitos e percepções inadequadas, o desconhecimento dos profissionais e as atitudes negligentes foram os principais achados encontrados no contexto do pré-natal odontológico na saúde pública do Brasil. Neste estudo, os dados encontrados demonstram desde fatores socioeconômicos a atitudes profissionais como empecilhos na prática do pré-natal odontológico na saúde pública do Brasil, o que reflete em precariedade nessa conduta assistencial e a necessidade de reformulação estrutural de políticas públicas para aplicabilidade. Diante disso, há inúmeros fatores limitantes para a efetivação dessa conduta no contexto da saúde bucal pública, tanto pela baixa procura pelo cuidado por parte das gestantes e pela negligência por parte dos profissionais. Assim como, visualiza-se a necessidade de fortalecer o processo de continuidade do cuidado através de campanhas e palestras educativas para um maior envolvimento das gestantes nesse período.
CARACTERIZAÇÃO DA BOVINOCULTURA DE LEITE URBANA NO MUNICÍPIO DE JOÃO PESSOA-PB
Authors: Veloso dos Santos Lima Tayná , Batista dos Santos Sandra , Santana de Moura Guilherme , Barbosa Junior Sebastião André , Cordão Maiza Araújo
Published: January 2024

O leite é um dos alimentos mais consumidos no mundo e o Brasil ocupa o quarto lugar no ranking da produção leiteira mundial. Dentro desta produção, existem pequenos produtores rurais que utilizam a bovinocultura de leite como principal renda para a sua família. Objetivou-se realizar uma caracterização do perfil socioeconômico desses pequenos produtores urbanos, identificando a forma de criação, manejo sanitário, reprodutivo e alimentar das vacas leiteiras. A pesquisa foi realizada em sete pequenas propriedades na região sul de João Pessoa-PB e foi baseada em um questionário abordando o perfil socioeconômico do produtor, o tipo de criação, os custos de produção e a renda obtida da atividade. Foram coletadas amostras de leite para teste diagnóstico de mastite clínica e subclínica utilizando o teste da caneca de fundo preto e o CMT (California Mastitis Test). Estes dados foram analisados por meio de estatística descritiva sobre os principais fatores estudados e os resultados apontaram que a bovinocultura de leite urbana da cidade de João Pessoa é representada por pequenos produtores sem assistência técnica, com pouco estudo, mão de obra inteiramente familiar e que as formas utilizadas no manejo produtivo e sanitário são rústicas. O conhecimento é repassado de pai para filho e permanece até hoje, desta forma sem acesso a novas tecnologias para a produção de leite e a ordenha é 100% manual. Com a crescente urbanização próxima destes produtores rurais, o leite é vendido na grande maioria para a população local, vizinhos e amigos.
De lo vivo a lo pintado. Dinámicas territoriales y representaciones culturales en una comarca mediterránea / From the living to the painting. Territorial dynamics and cultural representations in a Mediterranean region
Authors: Gómez Moreno María Luisa , Zayas Fernández Belén , Reyes Corredera Sergio
Published: January 2024

El litoral mediterráneo experimenta tensiones crecientes ejercidas por la difusión de nuevos usos urbanos y agrarios que amenazan sus valores ambientales y patrimoniales. Este artículo explora las posibilidades del concepto sistema GTP (geosistema, territorio y paisaje)como instrumento de apoyo para la regulación de estos procesos en la comarca de la Axarquía (Málaga, España) con el objetivo de armonizar valores culturales, económicos y ambientales.La côte méditerranéenne connaît des tensions croissantes dues à la diffusion de nouveaux usages urbains et agricoles qui menacent ses valeurs environnementales et patrimoniales. Cet article explore les possibilités du concept de système GTP (géosystème, territoire et paysage) en tant qu’instrument de soutien pour la régulation de ces processus dans la région d’Axarquía (Malaga, Espagne) dans le but d’harmoniser les valeurs culturelles, économiques et environnementales.The Mediterranean coast is under increasing tensions exerted by the diffusion of new urban and agricultural uses that menace its environmental and heritage values. This article explores the possibilities of the GTP system concept (geosystem, territory and landscape) as a support instrument for the regulation of these processes in the Axarquía region (Malaga, Spain) with the aim of harmonizing cultural, economic and environmental values.
Identifying Indicators of High-Conflict Divorce Among Parents
Authors: Deck Premela , Eisensmith Sarah , Skinner Brittany , Cafaro Jacqueline
Published: January 2024

The burgeoning field of forensic social work supports clients engaged in the legal system. Forensic social work professionals working in family court will often be called upon to assess family dynamics, provide treatment to reduce maladaptation post-divorce, and advise divorcing parents as they navigate the complexities of court. Of particular interest to the forensic social work field are the various risks and protective factors that escalate or mitigate interparental conflict throughout the divorce process. Interparental conflict is a primary moderator accounting for psychological and physiological differences between children of divorced parents and children with intact parents. This systematic review examined the factors that contribute to conflict in divorcing parents and ways to identify high-conflict cases,. Peer-reviewed articles (n=11) were systematically selected using rigorous methods, including PRISMA-P protocols for systematic reviews and database searches using the search string “conflict AND divorce*.” Articles were extracted to identify themes of varying levels of conflict. There is no consistent definition of high conflict in pre-divorce parents, and recent articles offer new conceptualizations of this construct. All studies that met inclusion criteria for the review identified at least one of five themes of pre-divorce conflict: conflict resolution/communication, social network, parent characteristics, satisfaction with agreements, and pervasive mistrust.
Deciphering the Influence of Mid-term Examinations on Student Learning Outcomes: A Comprehensive Investigation Employing Statistical and Machine Learning Approaches
Authors: Liu Liyuan , Han Meng
Published: January 2024

It is widely recognized that mid-term examinations serve as a fundamental assessment method for evaluating students’ learning progress at the midpoint of a semester. A plethora of previous studies have underscored the significance of mid-term exams as a determinant of final grades, exhibiting a positive correlation with final exam outcomes. Nevertheless, these investigations frequently analyze the entire student population without accounting for disparities in students’ mental states and learning objectives, particularly in the aftermath of receiving their mid-term exam results. In the present study, we scrutinize the mid-term and final grades of 171 students participating in a statistics course. Diverging from prior research, which typically employs the entire student data as a singular group, we partition students into two distinct categories: those who attain higher mid-term exam scores and those who secure lower mid-term exam scores. Our analysis reveals that students achieving higher mid-term exam scores are more likely to obtain lower final exam scores, while students with lower mid-term scores tend to attain superior final exam results. This phenomenon is attributed to the influence of learning from failure, which motivates students who initially underperform to adopt new strategies and strengthen their learning objectives. Furthermore, we utilize a non-linear Support Vector Machine (SVM) model to forecast students’ final performance, recognizing that learning is a non-linear process replete with uncertainties. The model’s interpretation discloses that the mid-term exam and assignments administered during the mid-term exam period constitute the most influential factors impacting students’ final performance. Consequently, the meticulous monitoring of students’ mid-term grades and the implementation of strategic incentives to bolster their learning outcomes are paramount for ensuring their success in academic courses.
Specifics of cystic fibrosis genetic spectrum in Georgia
Authors: Khurtsilava Ia , Agladze Dodo , Parulava Tsitsino , Margvelashvili Lali , Kvlividze Oleg
Published: January 2024

Cystic fibrosis (CF) is a life-threatening autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR). F508del is the most common mutation in the world. Other mutations are rare and population specific.

 The study aimed to comprehensively analyze the distribution of CFTR mutations in Georgian CF patients. Knowing the prevalence and characteristics of specific mutations can be reflected in genetic counseling and management strategies. 

We reviewed the data of 129 CF patients, aged < 18 years, from all parts of Georgia. 91 patients with a clinically confirmed CF diagnosis were tested for CF-causing mutations (constituting 70.5% of all currently registered CF patients in the country). These patients have been analyzed for rare CFTR variants by massively parallel sequencing of the entire CFTR coding region and adjacent introns combined with the analysis of intra-CFTR rearrangements. 

CFTR gene analysis revealed 29 mutations in Georgian CF patients. The most common mutation was c.1545_1546delTA (1677delTA) with a frequency of 42.7%, while the second most common mutation, W1282X, was detected in 11.2% of all CF alleles. Another 27 CFTR mutations have low frequency, including F508del (6.7% of alleles). 3 novel mutations were found (c.708dupT; CFTRdele16_17; c.3170C>G) and reported to CFTR2 database.

According to the data, the distribution of CFTR mutations in the Georgian CF population differs regarding the high frequency of mutation c.1545_1546delTA (1677delTA) and the low frequency of the predominant F508del mutation. Compared to patients with F508 del and W1282X mutations, patients with 1677delTA have typical manifestations and complications; however, the frequency of growth retardation and liver damage is 3 times, and the frequency of chronic respiratory manifestations and chronic malnutrition is 2 times lower, though pancreatic insufficiency is more severe in patients with 1677delTa. CF-associated diabetes, distal intestinal obstruction syndrome, and hemoptysis were only observed in patients with the 1677delTA mutation. The mortality rate is lower compared to patients with F508del and W1282X mutations.
Study of bacteriological profile and antibiotic susceptibility pattern of pus isolates in tertiary care hospital
Authors: Sajjanar Vijetha , DE Premalatha , KC Siddesh , N Prakash
Published: January 2024

Surgical wound causes invasion of pathogens causing surgical site infections which are commonly polymicrobial in nature. This pus forming infection causes delayed wound healing, wound dehiscence and wound breakdown contributing to important healthcare associated infections (HAI) Multidrug resistance has emerged among organisms isolated in pus sample due to failure of appropriate use of antibiotics.

: 1. To study the bacteriological profile of pus samples 2. To determine the antibiotic susceptibility pattern of isolated pathogens from pus samples.

The study was conducted in department of microbiology, Shimoga institute of medical sciences, Shimoga from January 2018 to June 2018.All pus samples were processed on blood agar, MacConkey agar and incubated at 37°c under aerobic conditions for 24 hours. The organisms were identified as per standard conventional methods. The antimicrobial susceptibility tests were done by Kirby–Bauer’s Disk Diffusion method on Mueller–Hinton Agar and interpreted as per clinical laboratory standard institution guidelines (CLSI).

Out of 350 samples 250 were culture positive 100 were culture negative. Among culture positive most common organism isolated was followed by 86(34.45%), 72(28.8%), 55(22%), 20(8%), 9(3.6%), 2(0.8%), 3(1.2%) 3(1.2%), 3(1.2%). Gram positive organisms were most sensitive for linezolid, vancomycin and least sensitive to cefoxitin, erythromycin. Gram Negative Organisms Were Most Sensitive for Imipenam, Piperacillin tazobactam and least Sensitive for Ampicillin-sulbactam, Ciprofloxacin

is most common etiology of pus forming infection most importantly surgical site infections (SSI). MRSA prevalence in hospital set up indicates the failure of proper infection control practices implementation in the hospitals causing healthcare associated infections (HAI). Emergence of multidrug resistance among the pus isolates is because of non-judicious use of antibiotics.
Piedra blanca: micosis superficial en un paciente pediátrico
Authors: Baquedano Ordoñez Abner Bladimir , Aguilar Gutiérrez Katia , Gómez Sosa Keshia Danae , Sierra Aguilar Sonia Ivana , Villanueva Ordoñez Josué David
Published: January 2024

ANTECEDENTES: La piedra blanca es una micosis superficial crónica causada por hongos de levadura del género Trichosporon. Es una infección rara, asintomática y crónica que afecta el cabello externamente, sin invadirlo; aparece en forma de nódulos adherentes, blandos y blanquecinos. Se localiza principalmente en la cabeza, pero puede afectar otras áreas en menor frecuencia.

CASO CLÍNICO: Paciente pediátrica de 5 años, con dermatosis de 6 meses de evolución, localizada en piel cabelluda, caracterizada por nódulos asintomáticos, de 2 a 3 mm, de consistencia firme, blanquecinos, adherentes, que rodeaban el tallo del cabello en intervalos irregulares; recibió múltiples fármacos, como pediculosis resistente a  tratamiento. Se llevaron a cabo estudios del pelo afectado (examen directo con KOH y cultivo por hongos). Se confirmó el diagnóstico de piedra blanca por Trichosporon cutaneum. Se brindó tratamiento tópico, con resultados satisfactorios luego de tres meses.

CONCLUSIONES: Existen enfermedades que producen lesiones nodulares en el pelo; por tanto, debe considerarse la piedra blanca dentro del diagnóstico diferencial, y efectuar en la medida de lo posible el abordaje integral y oportuno, para evitar el retraso en el diagnóstico, implementar tratamientos inadecuados y costos innecesarios a los pacientes.
Síndrome de Cushing iatrogénico y síndrome de supresión de esteroides por la prescripción de conticosteroides tópicos
Authors: Jaime Sànchez Myriam Azucena
Published: January 2024

ANTECEDENTES: Los corticosteroides tópicos representan uno de los tratamientos de primera línea de diversas enfermedades dermatológicas, debido a su efecto antiinflamatorio y antiproliferativo. Cuando se aplican de forma adecuada son seguros y eficaces; no obstante, la exposición prolongada puede producir efectos secundarios graves.

CASO CLÍNICO: Paciente femenina de 1 año y 7 meses, quien manifestó síndrome de Cushing iatrogénico y síndrome de supresión esteroidea por uso crónico y no supervisado de corticosteroides por vía tópica en el área del pañal.

CONCLUSIONES: Los corticoides tópicos son fármacos efectivos para el tratamiento de múltiples afecciones de la piel. El conocimiento de su prescripción es fundamental; por lo tanto, conocer los efectos adversos y el perfil de seguridad es imprescindible para la práctica pediátrica diaria.
construção de objetos de tecnodiscurso
Authors: Pinheiro Clemilton Lopes , Nogueira Stelyo Rubens de Souza
Published: January 2024

Neste trabalho, consideramos, por um lado, o quadro teórico da ADD (Análise do Discurso Digital), proposto por Marie-Anne Paveau, que tem como objeto de estudo o tecnodiscurso, isto é, produções discursivas digitais nativas que reúnem linguagem e tecnologia – intrinsecamente ligadas – em um compósito; por outro lado, o estudo de Lorenza Mondada, que propõe a noção de objetos de discurso como algo (uma espécie de “referente” discursivamente construído) em torno do qual a atividade enunciativa se organiza nas práticas de apreensão, formulação e descrição do mundo pelos falantes. Dadas as especificidades do tecnodiscurso, propomos a noção de objeto de tecnodiscurso, ou seja, referentes construídos pelos processos tecnodiscursivos, como categoria analítica da dinâmica tecnodiscursiva. As noções de objeto de discurso e objetos de tecnodiscurso guardam, portanto, semelhanças, mas também diferenças. Isso abre caminho para a problemática teórico-metodológica em torno da construção dos objetos de tecnodiscurso. Nosso objetivo é, portanto, apontar alguns elementos de reflexão sobre essa problemática.
Linguística textual, contrato comunicativo e tecnodiscursividade
Authors: Custódio Filho Valdinar , Hissa Débora Liberato Arruda
Published: January 2024

Este artigo propõe uma análise do processo de rolagem infinita efetivado em plataformas de mídias digitais a partir de critérios da linguística textual em suas interfaces com a proposta de contrato comunicativo (CHARAUDEAU, 2012) e tecnodiscurso (PAVEAU, 2021, entre outros trabalhos). Parte-se da convicção de que a coerência textual é depreendida a partir de um conjunto complexo de fatores, daí a necessidade de diálogos interdisciplinares (CAVALCANTE et al., 2020, 2022). Essa interlocução é particularmente importante para a análise de textos nativos digitais (PAVEAU, 2021), para o que é imperioso considerar as condições de tecnodiscursividade, dentre elas a deslinearização. Partimos da hipótese de que a descrição, no seio da linguística textual, da rolagem infinita se reverte de particularidades ainda não apontadas pelos estudiosos. Para tanto, analisamos dois feeds (cada um com vinte postagens) decorrentes de duas ações de navegação na plataforma Instagram. Os dados foram analisados em comparação com o processo de hiperlinkagem, para o qual são relevantes a intertextualidade e a continuidade temática (CAVALCANTE et al., 2022). Uma vez que essas duas estratégias não promovem os mesmos efeitos na rolagem infinita, há mudanças consideráveis em relação à deslinearização e ao papel do interlocutor no contrato comunicativo.
Trabalhos de pesquisa
Authors: Eixo Gestão - resumo expandido Associação Brasileira da Rede UNIDA -
Published: January 2024

Para ver o arquivo completo, acesse o seguinte link: http://historico.redeunida.org.br/congresso2016/v-2-n-1suplem-2016/at_download/file
Relatos de experiência
Authors: Eixo Rotas Críticas - resumo simples Associação Brasileira da Rede UNIDA -
Published: January 2024

Para ver o arquivo completo, acesse o seguinte link: http://historico.redeunida.org.br/congresso2016/v-2-n-1suplem-2016/at_download/file
Relatos de experiência
Authors: Eixo Rotas Críticas - resumo expandido Associação Brasileira da Rede UNIDA -
Published: January 2024

Para ver o arquivo completo, acesse o seguinte link: http://historico.redeunida.org.br/congresso2016/v-2-n-1suplem-2016/at_download/file
Analyzing teachers’ perceptions of the impact of Moodle personalized positive feedback on foreign language students’ motivation and engagement
Authors: Aissi Radhia , Mouas Samia
Published: January 2024

With the considerable growth of e/blended-learning, which has accelerated in HE settings, especially since 2020 due to the COVID-19 global pandemic, automated feedback (FB) has become the focus of increasing research interest (Cavalcanti, 2021). Yet, there is a scarcity of research that thoroughly examines the documented progress made up to date in this regard in Algerian universities. Thus, this study was carried out to capture university teachers’ perceptions of the impact of personalized positive FB via the Moodle platform on their students’ motivation and engagement in learning. The research design adopted consisted of quantitative data generated from teachers’ responses to an online questionnaire. Findings suggest that the importance of personalized positive FB emerges as a pivotal element in enhancing both motivation and engagement. Pearson correlation as a statistical technique was conducted to meet the objectives of this study. The results revealed a very weak relationship between teachers’ Moodle training and their quality of personalized automated FB and a weak correlation between teachers’ Moodle familiarity with personalized automated FB and their students’ motivation and engagement. Some important recommendations are presented.
Self-Defense Strategies Against Cyber- Attacks by Non-State Actors
Authors: Urbina Escobar Tomás
Published: January 2024

This article aims to analyze and provide a state-of-the-art conceptualization of the notion of self-defense within international law and the cyber realm. In the first section, the paper explores the concepts of self-defense, attack, and the use of force in international law, followed by their application in the cyberspace. The subsequent section, specifically applies the concept of self-defense in the event of a cyber-attack perpetrated by a non-state actors. The conclusion highlights that the cyber realm context introduces the possibility that aggressions from non-state actors can yield consequences even more severe than traditional kinetic attacks. This article serves as a foundation for future discussions in the defense sector and international law.
A Case of Myocardial Lipomatous Metaplasia as a Late Complication of Myocardial Infarction
Authors: Zoroufian Arezoo , Borjian Solmaz
Published: January 2024

The Article Abstract is not available.
New books on comics
Authors: Dzhumaylo O.A.
Published: January 2024

The review analyzes current issues and approaches in the academic study of comics on the material of generalizing scholar books published in 2020– 2022. The focus is on two dictionaries of key concepts in the field of comics studies (“Keywords for Comic Studies”, “Key Terms in Comics Studies”) and two collective monographs of a systematizing bent (“Comics Studies: a Guidebook”, “More Critical Approaches to Comics”). In addition, the monograph “Comics as a Research Practice: Drawing “Narrative Geographies Beyond the Frame” is discussed as an example of interdisciplinary (humanitarian geography in the study of comics) and activist practice in comics studies. The importance of research through the prism of a narrative approach is shown in the scholar book “The Narratology of Comic Art”. Taking into account the fact that comics are both a medium and an instrument of entertainment economics, politics, personal self-expression, and one of the notable forms of everyday culture, the following topical aspects of the theory and practice of studying comics are highlighted: the legitimization of comics in academic culture and contemporary neoliberal university; the intermedial / multimodal / transmedia status of comics; problematization of the concept of comics and its historiography as a constructed entity in dependence of the chosen scholar approach; specific historical, social, political, economic and cultural contexts in which comics are created and interpreted; comics as an expression of critical reflection and activist position (of the creator and of the researcher); intellectualization of academic discourse on comics; attention to the issues of specific poetics of comics as a verbal-visual-figurative medium, the breadth of its genre catalog, dynamic forms of distribution and consumption culture of comics (adaptation and transmedia storytelling).
Meaning making in the graphic novel by S. Anufriev and P. Pepperstein “The mythogenic love of castes”
Authors: Markov А.V.
Published: January 2024

The article explores a recently published graphic novel “The Mythogenic Love of Castes”, which is an art project based on the novel of the same name by S. Anufriev and P. Pepperstein. Pepperstein, the leader of the project, brought many artists on board to perform it, allowing the novel, which at its appearance was read exclusively as psychedelic and postmodern, to be actualized. In fact, being based on the ideas of Moscow Conceptualism this novel has offered a new type of unreliable narrator, which abandons Platonic and classicist schemes of a unified sequence of ideas and images. A number of explicit provisions of Moscow Conceptualism, in particular, the systematization of public and private experience on the basis of the general idea of the ordinary and the unbelievable, have been developed in the novel. The novel is not reduced to the psychedelic canon and new forms of storytelling but continues the experimental practice in the anthropology associated with the name of G. Garfinkel, whose method is partly assimilated through the work of Castaneda. But if in the 1990s this could be explained as a critique of ideologies, in the contemporary cultural situation a critique of self-evidence as a new explanation is needed. The graphic novel has several advantages for this critique of self-evidence: a) it allows us to convey both the main plot of psychedelic realism and the side plot of questioning obviousness, which when reading the book are often mixed together as a single motif of undermining familiar body images, b) it allows to focus not only on the action but also on the structure of the character’s thought, which has its own duration, c) it allows to introduce a series of iconological techniques which are impossible in the format of traditional illustrations for the novel. It is concluded that the graphic novel allows to give a consistent genre characteristic to the original literary novel.
Initial development of IEEE Very Small Size Soccer robots: Electromechanics, Computer Vision System and Navigation Strategy
Authors: Ferreira Ryan Henrique Xavier , Silva Pedro Lucas da , Oliveira Vinícius Caputo Resende de , Silva Junior Carlos Dias da , Freitas Elias José de Rezende
Published: January 2024

This paper presents the initial development of the IEEE Very Small Size Soccer (VSSS) robots, including the modeling and 3D printing of mechanical components, the integration of embedded electronics, a computer vision system, and the simulation of a navigation strategy. The proposed computer vision system can capture and process images during the VSSS match to provide the robots' and the ball's positions and velocities. From these odometry data, the proposed navigation strategy based on vector fields calculates commands to the robots, allowing different robot roles in the soccer match (striker, defender, and goalkeeper). This strategy, implemented in a simulator, is intuitive and has a low computational cost.