bluuebunny/crossref_metadata_2025 huggingface dataset:
Superfluid stiffness and Josephson quantum capacitance: Adiabatic approach and topological effects
Authors: Wang Jun-Ang , Assili Mohamed , Kotetes Panagiotis
Published: June 2024

We bring forward a unified framework for the study of the superfluid stiffness and the quantum capacitance of superconducting platforms exhibiting conventional spin-singlet pairing. We focus on systems which in their normal phase contain topological band touching points or crossings, while in their superconducting regime feature a fully gapped energy spectrum. Our unified description relies on viewing these two types of physical quantities as the charge current and density response coefficients obtained for slow spatiotemporal variations of the superconducting phase. Within our adiabatic formalism, the two coefficients are given in terms of Berry curvatures defined in synthetic spaces. Our paper lays the foundation for the systematic description of topological diagonal superfluid responses induced by singularities dictating the synthetic Berry curvatures. We exemplify our approach for concrete one- and two-dimensional models of superconducting topological (semi)metals. We discuss topological phenomena which arise in the superfluid stiffness of bulk systems and the quantum capacitance of Josephson junctions. We show that both coefficients become proportional to a topological invariant which counts the number of topological touchings or crossings of the normal phase band structure. These topological effects can be equivalently viewed as manifestations of chiral anomaly. Our predictions appear experimentally testable in topological semimetals with proximity-induced pairing, such as in graphene-superconductor hybrids at charge neutrality.

Published by the American Physical Society
2024
Unlearnable Games and “Satisficing” Decisions: A Simple Model for a Complex World
Authors: Garnier-Brun Jérôme , Benzaquen Michael , Bouchaud Jean-Philippe
Published: June 2024

As a schematic model of the complexity economic agents are confronted with, we introduce the “Sherrington-Kirkpatrick game,” a discrete time binary choice model inspired from mean-field spin glasses. We show that, even in a completely static environment, agents are unable to learn collectively optimal strategies. This is either because the learning process gets trapped in a suboptimal fixed point or because learning never converges and leads to a never-ending evolution of agent intentions. Contrarily to the hope that learning might save the standard “rational expectation” framework in economics, we argue that complex situations are generically and agents must do with solutions, as argued long ago by Simon []. Only a centralized, omniscient agent endowed with enormous computing power could qualify to determine the optimal strategy of all agents. Using a mix of analytical arguments and numerical simulations, we find that (i) long memory of past rewards is beneficial to learning, whereas overreaction to recent past is detrimental and leads to cycles or chaos; (ii) increased competition (nonreciprocity) destabilizes fixed points and leads first to chaos and, in the high competition limit, to quasicycles; (iii) some amount of randomness in the learning process, perhaps paradoxically, allows the system to reach better collective decisions; (iv) nonstationary, “aging” behavior spontaneously emerges in a large swath of parameter space of our complex but static world. On the positive side, we find that the learning process allows cooperative systems to coordinate around satisficing solutions with rather high (but markedly suboptimal) average reward. However, hypersensitivity to the game parameters makes it impossible to predict who will be better or worse off in our stylized economy. The statistical description of the space of satisficing solutions is an open problem.

Published by the American Physical Society
2024
Molecular Drivers of Aging in Biomolecular Condensates: Desolvation, Rigidification, and Sticker Lifetimes
Authors: Biswas Subhadip , Potoyan Davit A.
Published: June 2024

Biomolecular condensates are dynamic intracellular entities defined by their sequence- and composition-encoded material properties. During aging, these properties can change dramatically, potentially leading to pathological solidlike states, the mechanisms of which remain poorly understood. Recent experiments reveal that the aging of condensates involves a complex interplay of solvent depletion, strengthening of sticker links, and the formation of rigid structural segments such as beta fibrils. In this study, we use various coarse-grained models to investigate how solvent expulsion, biopolymer chain rigidity, and the lifetimes of sticker contacts influence the viscoelastic properties and aging dynamics of condensates. We find that the rigidity of the biopolymer backbone is essential for replicating the predominant elastic behavior observed in experiments. In contrast, models using fully flexible chains—an assumption common in simulations of intrinsically disordered proteins—fail to exhibit a dominant elastic regime. We also demonstrate that altering the solvent content within condensates affects the crossover between storage and loss moduli. This suggests that desolvation plays a significant role in condensate aging by promoting the transition from a viscous to an elastic state. Furthermore, the lifetime of sticker pairs profoundly influences the mature state of the condensates; short-lived stickers lead to a Maxwell fluid behavior, while longer-lived, irreversibly cross-linked stickers result in solidlike properties, consistent with the Kelvin-Voigt model. Finally, by incorporating the chain rigidification, desolvation, and sticker pair formation into a nonequilibrium dynamic aging simulation, we show the molecular mechanism of forming solid shells around the condensate surfaces observed in a recent experimental report.

Published by the American Physical Society
2024
Conflict resolution: how to LEVEL
Authors: Marques Joan F.
Published: June 2024

Purpose

To assist managers in applying a set of intuitively appealing actions that can be helpful in conflict resolution.

Design/methodology/approach

Utilizing a mindful strategy of listening, empathizing, visualizing, considering effects, and liaising with involved parties toward resolving conflicts in a mutually considerate way.

Findings

Leveling with colleagues, especially when in a supervisory position, will demonstrate respect for individual perspectives, and the will to reflect on both sides of a situation before coming to a decision.

Practical implications

Applying LEVEL may take more time than jumping to quick conclusions, but it will enhance employees’ reverence for their leader, as they find that decisions are well-considered, and respectfully communicated.

Originality/value

An intuitively sound way of leading mindfully and respectfully in increasingly complex work environments.
Organisational vulnerability: exploring the pathways
Authors: Chipangura Paul , van Niekerk Dewald , Mangara Fortune , Zembe Annegrace
Published: June 2024

Purpose

This study aimed to address the underexplored domain of organisational vulnerability, with a specific focus on understanding how vulnerability is understood in organisations and the underlying pathways leading to vulnerability.

Design/methodology/approach

This study utilised a narrative literature review methodology, using Google Scholar as the primary source, to analyse the concepts of organisational vulnerability in the context of disaster risk studies. The review focused on relevant documents published between the years 2000 and 2022.

Findings

The analysis highlights the multifaceted nature of organisational vulnerability, which arises from both inherent weaknesses within the organisation and external risks that expose it to potential hazards. The inherent weaknesses are rooted in internal vulnerability pathways such as organisational culture, managerial ignorance, human resources, and communication weaknesses that compromise the organisation’s resilience. The external dimension of vulnerability is found in cascading vulnerability pathways, e.g. critical infrastructure, supply chains, and customer relationships.

Originality/value

As the frequency and severity of disasters continue to increase, organisations of all sizes face heightened vulnerability to unforeseen disruptions and potential destruction. Acknowledging and comprehending organisational vulnerability is a crucial initial step towards enhancing risk management effectiveness, fostering resilience, and promoting sustainable success in an interconnected global environment and an evolving disaster landscape.
Relationship between firefighter protective clothing design ease and heat stress
Authors: Boisvert Reannan , McQuerry Meredith , Schofield Sheryl
Published: June 2024

Purpose

Clothing fit, including garment ease and drape, impacts the volume of air between clothing layers and the body, directly affecting the amount of heat that can be transferred through a multi-layer clothing system. As most acute firefighting fatalities are caused by overexertion and heat strain, the purpose of this research was to determine the impact of ease allowances on air gaps in structural firefighting turnout suits and their subsequent effect on total heat loss (THL) when worn on a three-dimensional form.

Design/methodology/approach

Four turnout suits with chest ease allowances of 6″, 8″, 10″ and 12″ were evaluated using an ANDI dynamic sweating thermal manikin. The average predicted manikin THL of each ensemble was calculated from the thermal and evaporative resistance measurements. A three-dimensional (3D) body scanner was utilized to calculate the distance and volume of clothing air gaps between the base layer and each turnout suit.

Findings

Results demonstrate that reductions in upper body ease measurements trend towards statistically significant increases in THL, to a point, with fit limitations being reached before benefits can be significantly realized. An increase in standard chest ease measurements significantly decreased heat loss, even when forced convection from movement was considered.

Originality/value

This is the first article of its kind to explore the relationship between garment ease and predicted manikin THL, especially for fire service protective clothing. Findings indicate a valid recommendation for turnout gear designers and manufacturers to optimize clothing fit to improve breathability and potentially reduce incidents of heat strain in the fire service.
Roles and responsibilities of stakeholders involved in local-level flood risk management: a study in the Deduru Oya basin in Sri Lanka
Authors: Wanninayake Sisira Bandara , Nianthi Rekha , Dayarathne Banda O.G.
Published: June 2024

Purpose

Disasters are occurring worldwide, and Sri Lanka has also become a victim of multiple disasters. Though there is a disaster management mechanism from the national level to the local level in Sri Lanka, several gaps are identified in pre- and postdisaster management activities. Among them, the responsibilities of local-level stakeholders in flood management activities are not performing at a satisfactory level. Therefore, the flood damage from the previous events was too great. Accordingly, the purpose of this study is to assess the roles, responsibilities and performance of stakeholders involved in local-level flood risk management activities.

Design/methodology/approach

The Deduru Oya basin in Sri Lanka was selected as the study area. The study hypothesized that “ineffective roles, responsibilities and performance of local level stakeholders have weakened the flood risk management in the Deduru Oya basin.” The stratified random sampling method selected the sample (n = 425) from the flood-vulnerable population. Primary data were collected through a questionnaire survey, key informant interviews and field observations. Secondary data were collected from reports, work plans, journal papers and published maps. Descriptive data analysis methods and thematic data analysis methods were used in the study.

Findings

About 69% of the respondents state that they are not satisfied with the involvement of government agencies in local-level flood risk management activities, while 10% of the respondents state that they are satisfied. The thematic analysis reveals several gaps, such as the lack of reservations in the Deduru Oya, improper land use practices, no inundation areas are identified and mapped out and the effects of illegal sand mining in the Deduru Oya. In addition to that, the lack of legal power vested in local governments in disaster management and the weaknesses of current legislation on flood risk management are the other major courses of local-level ineffectiveness.

Research limitations/implications

The current research was limited to studying the involvement of local-level stakeholders in flood risk management, but the involvement of subnational and national-level stakeholders should be studied in future research.

Originality/value

This paper examines the involvement of local-level stakeholders in flood risk management. The results of the study confirm that the roles and responsibilities of local-level stakeholders are not well-defined and mandated, and therefore, the performance of stakeholders involved is minimal. Therefore, the results highlight the need for a well-established community-based flood risk management mechanism.
Centrality of sensory attributes in brand extension evaluations
Authors: Sekar Samuel Babu , Varki Sajeev , Elsantil Yasmeen
Published: June 2024

Purpose

Compared to typical brand extension research focusing on functional and symbolic attributes, this paper aims to examine brand extensions based on a brand's primary sensory attributes. Specifically, this paper investigates the interplay between brand equity and primary sensory attributes in shaping consumers' evaluations of brand extensions.

Design/methodology/approach

This study investigates the impact of primary or central sensory attributes on brand extension evaluations for brands with differing brand equities. The authors conducted two experiments preceded by seven pretests to develop and validate the stimulus materials. The authors aim to contribute to understanding how sensory and brand-related factors influence consumers' evaluations of brand extensions.

Findings

In these experiments, the authors find that a parent brand's central/dominant sensory attribute allows the parent brand to successfully extend into functionally unrelated categories. For example, Dove’s central attribute of touch allows it to extend successfully into categories such as towels and shaving razor. However, it does not perform as well as Irish Spring (known for smell) in categories such as cologne and scented fabric softener, where Irish Spring's central attribute of smell is more relevant. Interestingly, Irish Spring, a lower equity brand, outperforms Dove in smell-related extensions, indicating that sensory attributes can counter the impact of lower brand equity if the sensory attribute is relevant to the extension category.

Originality/value

This study investigates brand extensions based on sensory attributes such as smell and touch instead of typical brand extensions based on functional and symbolic attributes. In particular, the authors examine whether the perceived fit between the parent brand’s dominant sensory attribute and the extended category (i.e. sensory fit) is more important than the parent brand's equity in the evaluation of brand extensions.
Does coaching leadership facilitate employees' taking charge? A perspective of conservation of resources theory
Authors: Ren Lei , Yin Yishuai , Zhang Xiaobin , Zhu Di
Published: June 2024

Purpose

The purpose of this research is to examine the relationship between coaching leadership and employees' taking charge while incorporating the mediating role of work meaningfulness and the moderating role of challenge-hindrance stressor.

Design/methodology/approach

A total of 355 pairs of effective samples were collected through a two-stage supervisor-subordinate paired survey. Four hypotheses were tested using hierarchal regression analysis and bootstrapping method.

Findings

The findings show that coaching leadership is positively related to taking charge, and work meaningfulness positively mediates the coaching leadership-taking charge relationship; high challenge stressors and high hindrance stressors weaken the positive effect of coaching leadership on work meaningfulness respectively; challenge stressors and hindrance stressors further moderate the indirect relationship of coaching leadership and taking charge through work meaningfulness.

Originality/value

This study provides a new perspective for organizations to activate employees' taking charge, thereby enriching the antecedents of taking charge. By incorporating challenge-hindrance stressor framework, this study also provides answers to when coaching leadership will be less effective.
Transformational leadership and work engagement in remote work settings: the moderating role of the supervisor’s digital communication skills
Authors: Boccoli Gabriele , Gastaldi Luca , Corso Mariano
Published: June 2024

Purpose

This study explores the impact of transformational leadership on work engagement within remote work settings. More specifically, we investigate whether supervisor’s perceived digital communication skills moderate the relationship between perceived supervisor support and work engagement.

Design/methodology/approach

Moderated mediation model has been tested using a sample of 410 consultants in Italy who worked within a fully remote work setting during Covid-19 pandemic.

Findings

Drawing on construal level theory and social presence theory, our study provides insights into the dynamics of leadership and work engagement in remote work settings. We demonstrate that, despite the challenges posed by physical distance, transformational leaders can effectively stimulate the work engagement of remote collaborators. Moreover, our findings suggest that the perceived digital communication skills of supervisors play a crucial role in moderating the relationship between perceived supervisor support and work engagement. This underscores the importance of supervisors' adept use of digital tools in conveying psychological presence and fostering employee engagement in remote work environments.

Practical implications

Our study highlights the importance of developing supervisors' digital communication skills to support and stimulate employee engagement in remote work settings.

Originality/value

This study contributes to the literature by providing one of the first empirical tests of the relationship between transformational leadership, perceived supervisor support, supervisor’s digital communication skills and work engagement within a remote work setting. By challenging prior assumptions and offering novel insights, our research enhances understanding of leadership dynamics and provides practical guidance for organizations navigating the challenges of remote work.
A quantitative analysis of cosmeceuticals: business service quality and client satisfaction
Authors: Bond Mariah C.
Published: June 2024

Purpose

The purpose of the quantitative correlational research study was to determine the relationship, if any, between the predictor variable, cosmeceutical business service quality, and the outcome variable, cosmeceutical client satisfaction, in the southeast region of the United States of America. Cosmeceuticals were cosmetics and medications administered by estheticians.

Design/methodology/approach

Literature on business service quality and client satisfaction theories was synthesized after extensive review. Quantitative research data were collected and statistically analyzed on the following subscales of consumer satisfaction: general satisfaction, technical quality, interpersonal manner, communication, financial aspects, time spent with professionals and accessibility/convenience. The hypotheses addressed the research question (RQ) of whether cosmeceutical business service quality affects client satisfaction. The Cosmeceutical Client Satisfaction Questionnaire 18 (CCSQ-18), a web-based research instrument, had strong reliability with a Cronbach’s alpha of 0.84. The target population (N = 50) included randomly selected female cosmeceutical consumers in the southeast region of the United States of America. The researcher did not digress from the detailed research protocol, instrumentation, data collection or data analyses. Through the Likelihood Ratio (LR) chi-squared statistic (18) = 65.35 and its associated probability, Prob > chi-squared = 0.000, the researcher determined the predictor variable cohesively has a statistically significant effect on the outcome variable.

Findings

Research results concluded that a significant relationship exists between cosmeceutical business service quality and cosmeceutical client satisfaction in the southeast region of the United States of America.

Originality/value

The findings detailed in the results complimented the argument that, generally, business service quality is important to consider, because good business is based on client satisfaction.
What is the role of national media environments in shaping the impact of CSR on a firm’s performance?
Authors: Hong Gahye , Cho Hyo Eun , Kim Juhee , Shin Jiyoung
Published: June 2024

Purpose

This study aims to contribute to the existing literature on corporate social responsibility (CSR) by examining the influence of national media environments on the economic consequences of CSR. Drawing on signaling theory, this study distinguishes between two country-level media environments − digital media accessibility and media freedom − of which the prior research has often implied their value in cultivating the stakeholders’ awareness about the firms’ socially responsible behavior, suggesting that they amplify the benefits of CSR actions.

Design/methodology/approach

This study conducts multilevel analysis with a sample of 44,222 firm-year observations representing 6,726 companies from 57 countries over the period 2003–2019.

Findings

This study finds supportive evidence that CSR is more positively related to financial gains in countries with greater digital media accessibility. This study concludes that digital media accessibility affects a firm’s reputation and legitimacy benefits derived from CSR actions, resulting in better financial performance (FP).

Originality/value

The findings of this paper contribute to the existing literature on the CSR–FP relationship by demonstrating the relevance of considering the media environment to better explain the link between CSR and FP. In doing so, this study enriches our understanding of the importance of the media at macro-level institutions by examining how and why these media environments cultivate a culture of CSR as a strategic tool for firms.
Victoria’s Secret: the falling angels
Authors: Majumdar Arup , Prabha Subba Lakshmi , Sachdeva Kirti
Published: June 2024

Research methodology

Secondary research

Case overview/synopsis

Victoria’s Secret, a lingerie retailer founded by Roy Raymond in 1977, is the largest retailer in women’s intimate apparel in North America. Nevertheless, the business has been under fire in the recent past for failing to be inclusive and diverse, declining revenues and engaging in high-profile controversies. Victoria's Secret has experienced competition from emerging lingerie brands including Savage X Fenty, which Rihanna established in 2018, ThirdLove and Aerie by American Eagle & Knix. Victoria's Secret tried to reinvent itself in reaction to these difficulties by altering its marketing approach, switching out its “angels” for more diversified models, and launching a new range of cozy, informal loungewear. However, there were conflicting reactions to these initiatives, and the company's sales have been declining.

Complexity academic level

Executive training programs, upper level undergraduate and graduate MBA students in strategic, marketing and general management. Students should understand the basics of strategic management and marketing before undertaking to analyse this case.
Elevated CO2 enhances decomposition and modifies litter‐associated fungal assemblages in a natural Eucalyptus woodland
Authors: Nielsen Uffe N. , Bristol Dylan , Blyton Michaela , Delroy Brendan , Powell Jeff R.
Published: June 2024

Litter decomposition is a key process governing carbon and nutrient cycles in forest ecosystems that is expected to be impacted by increasing atmospheric carbon dioxide (CO2) concentrations.

We conducted two complementary field studies to assess the effects of elevated CO2 on Eucalyptus tereticornis litter decomposition processes. First, we used bags of two different mesh sizes to assess the effect of macrofauna and elevated CO2 over 24 months on mass loss of litter grown under ambient CO2. We then assessed the effect of elevated CO2 during the decomposition of litter grown under each combination of (i) ambient CO2 or elevated CO2 and (ii) during a psyllid outbreak that triggered significant canopy loss or later in canopy developing when psyllid densities were low.

Both macrofauna and elevated CO2 enhanced mass loss at late decay stages in the first study, with no interactive effect. Again, mass loss was greater at elevated CO2 at late decay stages in the second study, particularly for non‐psyllid‐impacted litter grown at elevated CO2. In both studies, CO2 concentration during decomposition influenced fungal assemblages and these effects were observed before any effects on decomposition were observed, with some fungi linked to saprotrophic guilds being found with higher frequency under elevated CO2. CO2 concentrations under which leaves developed and whether leaves were psyllid‐impacted was also important in shaping fungal assemblages.

Synthesis. The positive effect on mass loss at late decay stages is contrary to previous findings where elevated CO2 generally reduced decomposition rates. Our results show that elevated CO2 effects on decay rates are context‐specific. Further research is required to establish the mechanisms through which this occurs to better model elevated CO2 effects on global carbon dynamics.

Read the free Plain Language Summary for this article on the Journal blog.
Whole‐exome sequencing‐based mutational profiling of hepatocellular adenoma malignant transformation to hepatocellular carcinoma
Authors: Bu Yichao , Huang Run , Gao Jun , Qu Weifeng , Fu Xiutao , Liu Weiren , Ding Zhenbin , Zhou Jian , Fan Jia , Wang Xin , Chen Diyu , Tang Zheng
Published: June 2024

Hepatocellular adenoma (HCA) represents a rare benign hepatic neoplasm with potential for malignant transformation into hepatocellular carcinoma (HCC), yet the underlying mechanism remains elusive. In this study, we investigated the genomic landscape of this process to identify therapeutic strategies for blocking malignant transformation. Using micro‐detection techniques, we obtained specimens of adenoma, cancerous neoplasm and adjacent normal liver from three patients undergoing hepatic resection surgery. Whole‐exome sequencing (WES) was performed, and genomic interactions between HCA and HCC components within the same tumour were evaluated using somatic variant calling, copy number variation (CNV) analysis, clonality evaluation and mutational signature analysis. Our results revealed genomic heterogeneity among patient cases, yet within each sample, HCA and HCC tissues exhibited a similar mutational landscape, suggesting a high degree of homology. Using nonnegative matrix factorization and phylogenetic trees, we identified shared and distinct mutational characteristics and uncovering necessary pathways associated with HCA–HCC malignant transformation. Remarkably, we found that HCA and HCC shared a common monoclonal origin while displaying significant genetic diversity within HCA–HCC tumours, indicating fundamental genetic connections or evolutionary pathways between the two. Moreover, elevated immune therapy‐related markers in these patients suggested heightened sensitivity to immune therapy, providing novel avenues for the treatment of hepatic malignancies. This study sheds light on the genetic mechanisms underlying HCA–HCC progression, offering potential targets for therapeutic intervention and highlighting the promise of immune‐based therapies in managing hepatic malignancies.
The community of root fungi is associated with the growth rate of Norway spruce (Picea abies)
Authors: Hamberg Leena , Vanhatalo Jarno , Velmala Sannakajsa , Taylor Andy F. S. , MacKay John , Caron Sébastien , Asiegbu Fred O. , Sievänen Risto , Raumonen Pasi , Hytönen Tuija , Pennanen Taina
Published: June 2024

Our study delved into the relationship between root‐associated fungi, gene expression and plant morphology in Norway spruce cuttings derived from both slow‐and fast‐growing trees. We found no clear link between the gene expression patterns of adventitious roots and the growth phenotype, suggesting no fundamental differences in the receptiveness to fungal symbionts between the phenotypes. Interestingly, saplings from slow‐growing parental trees exhibited a higher richness of ectomycorrhizal species and larger roots. Some ectomycorrhizal species, typically found on mature spruces, were more prevalent on saplings from slow‐growing spruces. The ericoid mycorrhizal fungus, Hyaloscypha hepaticola, showed a stronger association with saplings from fast‐growing spruces. Moreover, saplings from slow‐growing spruces had a greater number of Ascomycete taxa and free‐living saprotrophic fungi. Aboveground sapling stems displayed some phenotypic variation; saplings from fast‐growing phenotypes had longer branches but fewer whorls in their stems compared to those from the slow‐growing group. In conclusion, the observed root‐associated fungi and phenotypic characteristics in young Norway spruces may play a role in their long‐term growth rate. This suggests that the early interactions between spruces and fungi could potentially influence their growth trajectory.
Antenatal pyelonephritis hospitalisation trends, risk factors and associated adverse outcomes: A retrospective cohort study
Authors: Gandhi Christy , Wen Timothy , Liu Lilly Y. , Booker Whitney A. , D'Alton Mary E. , Friedman Alexander M.
Published: June 2024

Objective

To analyse trends, risk factors and adverse outcomes associated with antenatal pyelonephritis hospitalisations.

Design

Retrospective cohort.

Setting

A national sample of US delivery hospitalisations with associated antenatal hospitalisations.

Population

US delivery hospitalisations in the Nationwide Readmissions Database from 2010 to 2020.

Methods

Antenatal hospitalisations with a pyelonephritis diagnosis within the 9 months before delivery hospitalisation were analysed. Clinical, demographic and hospital risk factors associated with antenatal pyelonephritis hospitalisations were analysed with unadjusted and adjusted logistic regression models with unadjusted and adjusted odds ratios as measures of effect. Temporal trends in antenatal pyelonephritis hospitalisations were analysed with Joinpoint regression to determine the relative measure of average annual percent change (AAPC). Risk for severe maternal morbidity and sepsis during antenatal pyelonephritis hospitalisations was similarly analysed with Joinpoint regression.

Results

Of an estimated 10.2 million delivery hospitalisations, 49 140 (0.48%) had an associated antenatal pyelonephritis hospitalisation. The proportion of deliveries with a preceding antenatal pyelonephritis hospitalisation decreased by 29% from 0.56% in 2010 to 0.40% in 2020 (AAPC −2.9%, 95% CI −4.0% to −1.9%). Antenatal pyelonephritis decreased, but risk for sepsis diagnoses increased during these hospitalisations from 3.7% in 2010 to 18.0% in 2020 (AAPC 17.2%, 95% CI 14.2%–21.1%). Similarly, risk for severe morbidity increased from 2.6% in 2010 to 4.4% in 2020 (AAPC 5.5%, 95% CI 0.8%–10.7%).

Conclusion

Antenatal pyelonephritis admissions appear to be decreasing in the USA. However, these hospitalisations are associated with a rising risk for sepsis and severe maternal morbidity.
Critically appraised topic: the use of vaccination to control the spread of foot‐and‐mouth disease in Australian livestock in the event of an incursion
Authors: Humphries B , Ward MP
Published: June 2024

With recent outbreaks of foot‐and‐mouth disease (FMD) in Indonesia and Bali, industry, government and public concern for its incursion into Australia is increasing. The potential impact of an outbreak on the agricultural industry and national economy could be devastating. To date, research conducted in relation to FMD in Australia predominantly concerns simulations and models performed to predict various outcomes. This project critically appraises the current literature regarding the simulated use of vaccination and its effectiveness for controlling the spread of FMD in Australia in the event of an outbreak. Findings from 10 modelling studies suggest that vaccination is effective at controlling the size and duration of an outbreak (under certain conditions), however, there is less clarity about cost‐effectiveness.
Parents' mental state language and child gender: A scoping review of developmental evidence
Authors: Farrell Callyn , Sanderson Ellen , Mulvihill Aisling , Thai Michael , Slaughter Virginia
Published: June 2024

Mental state language (MSL) is an important mechanism through which children learn about their social world and place within it. Previous research has suggested that parents may use MSL differently towards children based on their child's gender. However, findings are inconsistent. This scoping review explores the consistency of reported differences in parents' MSL use as a function of children's gender while exploring the methodological variables that may provide insights into these differences. Based on a review of the 27 studies included, 12 found a significant relationship between child gender and parents' MSL, while the remaining did not. The included studies used a range of methodological approaches to elicit MSL. This scoping review allows researchers and practitioners to reflect upon assumptions regarding the associations between child gender and parents' MSL. Further, we call for the use of diverse and informed approaches when studying these associations from a developmental perspective in the future.
COVID‐19 school closures and Chinese children's school readiness: Results from the natural experimental data
Authors: Tan Tony Xing , Wang Joy Huanhuan , Zhou Yi
Published: June 2024

Aims

To determine the associations between COVID‐19 school closures and school readiness skills for Chinese kindergarteners.

Design

We utilized the natural experimental condition created by local COVID‐19 outbreaks in 2022 (Study 1) to compare school readiness skills of children whose kindergartens were closed for 5 months (Group 1) with children whose kindergartens stayed open (Group 2). We further compared the school readiness skills of one pre‐COVID‐19 cohort (Cohort 2019) with one COVID‐19 cohort (Cohort 2021) from a fifth kindergarten (Study 2).

Samples

For Study 1, Group 1 included 445 children and Group 2 included 584 children aged 4–6 years. For Study 2, Cohort 2019 included 156 children and Cohort 2021 included 228 children aged 3–6 years.

Measures

For both studies, survey data on four school readiness skills were collected from parents. Additionally, Study 1 collected parental locus of control data from parents.

Results

Controlling for covariates, Study 1 revealed that Group 1 and Group 2 did not differ in terms of language and emergent literacy or approaches to learning. However, Group 1 scored lower than Group 2 on health and well‐being and arts and imagination. Study 2 revealed that Cohort 2021 scored higher than Cohort 2019 on language and emergent literacy but lower on the other three skills.

Conclusions

The associations of COVID‐19 school closures with Chinese children's school readiness skills were not uniform, with a positive relation with language and emergent literacy and negative associations with health and well‐being, approaches to learning, as well as arts and imagination.
Response rates to second‐line treatment with daratumumab bortezomib dexamethasone (DVD) in relapsed/refractory light chain amyloidosis (AL) after initial Bortezomib‐based regime
Authors: Bomsztyk Joshua , Ravichandran Sriram , Khwaja Jahanzaib , Cohen Oliver , Rauf Muhammad U. , Foard Darren , Martinez‐Naharro Ana , Venneri Lucia , Whelan Carol , Fontana Marianna , Hawkins Philip N. , Gillmore Julian , Lachmann Helen , Mahmood Shameem , Wechalekar Ashutosh D
Published: June 2024

Bortezomib is regularly used as frontline therapy for systemic AL amyloidosis. We assess the efficacy of second‐line daratumumab‐bortezomib‐dexamethasone (DVD) in AL amyloidosis in bortezomib‐exposed patients. A total of 116 patients treated with second‐line DVD were identified from a prospective observational study of newly diagnosed AL amyloidosis (ALchemy). DVD was initiated in both the relapsed setting or where there was an inadequate response defined as very good partial response (VGPR) or VGPR with organ progression/lack of organ improvement. A complete response (CR)/VGPR to second‐line DVD was achieved in 81 (69.8%) patients. A CR/VGPR was achieved in 67 (79.7%) in those who achieved a VGPR/CR to first line versus 14/32 (43.8%) in those who did not. Where DVD was initiated due to an inadequate response to first line (vs. at relapse), the median event‐free survival (EFS) was 18 vs. 34 months (p = 0.002). If a CR/VGPR was achieved to DVD, the 2‐year EFS was still lower in those with prior inadequate response 54% vs. 66% (p = 0.062). DVD is an efficacious second‐line treatment in systemic AL amyloidosis in a bortezomib‐exposed population. However, the response to DVD is poorer in those with an inadequate response to first‐line bortezomib.
Silibinin, a commonly used therapeutic agent for non‐alcohol fatty liver disease, functions through upregulating intestinal expression of fibroblast growth factor 15/19
Authors: Bai Yujie , Zhang Jing , Li Jialin , Liao Minghui , Zhang Yajing , Xia Yufeng , Wei Zhifeng , Dai Yue
Published: June 2024

Background and Purpose

Silibinin is used to treat non‐alcohol fatty liver disease (NAFLD) despite having rapid liver metabolism. Therefore, we investigated the role of the intestine in silibinin mechanism of action.

Experimental Approach

NAFLD mice model was established by feeding them with a high‐fat diet (HFD). Liver pathological were examined using H&E and oil red O staining. Tissue distribution of silibinin was detected by LC–MS/MS. SiRNA was employed for gene silencing and plasmid was used for gene overexpression. ChIP‐qPCR assay was performed to detect the levels of histone acetylation. Recombinant adeno‐associated virus 9‐short hairpin‐fibroblast growth factor (FGF)‐15 and ‐farnesoid X receptor (FXR; NR1H4) were used to knockdown expression of FGF‐15 and FXR.

Key Results

Oral silibinin significantly reversed NAFLD in mice, although liver concentration was insufficient for reduction of lipid accumulation in hepatocytes. Among endogenous factors capable of reversing NAFLD, the expression of Fgf‐15 was selectively up‐regulated by silibinin in ileum and colon of mice. When intestinal expression of Fgf‐15 was knocked down, protection of silibinin against lipid accumulation and injury of livers nearly disappeared. Silibinin could reduce activity of histone deacetylase 2 (HDAC2), enhance histone acetylation in the promoter region of FXR and consequently increase intestinal expression of FGF‐15/19.

Conclusion and Implications

Oral silibinin selectively promotes expression of FGF‐15/19 in ileum by enhancing transcription of FXR via reduction of HDAC2 activity, and FGF‐15/19 enters into circulation to exert anti‐NAFLD action. As the site of action is the intestine this would explain the discrepancy between pharmacodynamics and pharmacokinetics of silibinin.
Highlighting the importance of biodiversity conservation through the Holy Qur'an
Authors: Blankinship Lisa A. , Gillaspie Sarah , Aboul‐Enein Basil H.
Published: June 2024

Religious environmentalism relies upon religious texts and leadership to promote effective and long‐lasting change for environmental problems, such as responsible use and conservation of natural resources and biodiversity. World religions note the importance of biodiversity and humanity's responsibility in stewarding biodiversity as a member of ecological communities. We reviewed Quranic verses that relate to biodiversity and align with United Nations Sustainable Development Goals (SDGs). The Holy Quran was reviewed in electronic and hard copy formats, and verses related to biodiversity were translated to English and tabulated by Qur'anic chapter, verse, and narrative citation. Twenty‐one Qur'anic verses were identified that addressed biodiversity. Scriptures were divided into 5 groups that addressed provision of resources, governance or stewardship of resources, nature as a teacher, and human life in nature's communities or described creation of biodiversity. Qur'anic verses were aligned with 4 SDGs (goals 12–15), which address sustainable consumption of natural resources, global climate change, life in marine environments, and life in terrestrial environments, including freshwater ecosystems. This alignment demonstrates the interconnectedness of life, that conservation of biodiversity is referenced in the Quran, and how positive management of natural recourses can be beneficial to Muslim communities on local, national, and global scales. Positive movement toward ecofriendly practices, sound environmental resource use and management, biodiversity conservation, and governmental policies on conservation can be promoted through scriptures from the Holy Qur'an.
Patterns and correlates of potential range shifts of bat species in China in the context of climate change
Authors: Ke Can , Gong Li‐xin , Geng Yang , Wang Zhi‐qiang , Zhang Wen‐jun , Feng Jiang , Jiang Ting‐lei
Published: June 2024

Climate change may diminish biodiversity; thus, it is urgent to predict how species’ ranges may shift in the future by integrating multiple factors involving more taxa. Bats are particularly sensitive to climate change due to their high surface‐to‐volume ratio. However, few studies have considered geographic variables associated with roost availability and even fewer have linked the distributions of bats to their thermoregulation and energy regulation traits. We used species distribution models to predict the potential distributions of 12 bat species in China under current and future greenhouse gas emission scenarios (SSP1‐2.6 and SSP5‐8.5) and examined factors that could affect species’ range shifts, including climatic, geographic, habitat, and human activity variables and wing surface‐to‐mass ratio (S‐MR). The results suggest that Ia io, Rhinolophus ferrumequinum, and Rhinolophus rex should be given the highest priority for conservation in future climate conservation strategies. Most species were predicted to move northward, except for I. io and R. rex, which moved southward. Temperature seasonality, distance to forest, and distance to karst or cave were the main environmental factors affecting the potential distributions of bats. We found significant relationships between S‐MR and geographic distribution, current potential distribution, and future potential distribution in the 2050s. Our work highlights the importance of analyzing range shifts of species with multifactorial approaches, especially for species traits related to thermoregulation and energy regulation, to provide targeted conservation strategies.
Epidemiological case‐control study on contact sensitisation in female foot care specialists with occupational contact dermatitis: Patch test data of the Information Network of Departments of Dermatology (IVDK), 2008 to 2022
Authors: Brans Richard , Schröder‐Kraft Claudia , Gina Michal , Heratizadeh Annice , Weisshaar Elke , Bauer Andrea , Strom Kerstin , Skudlik Christoph , Schubert Steffen ,   for the IVDK
Published: June 2024

Background

Mainly women work as foot care specialists (FCS). They are at risk to develop occupational dermatitis (OD).

Objectives

The objective of this study is to describe the contact sensitisation pattern of female FCS with OD.

Methods

In a retrospective study, patch test and clinical data collected by the Network of Departments of Dermatology (IVDK) from 2008 to 2022 were analysed. Data of 116 female FCS with OD were compared with data of 13 930 female patients with OD working in other professions and 78 612 female patients without OD.

Results

Hand dermatitis (93.1%) was significantly more common and face dermatitis (0.9%) significantly less common in female FCS with OD compared to other female patients with or without OD. Frequent suspected allergen sources were disinfectants, gloves, leave‐on and nail cosmetics. Occlusion and wetness were important co‐factors. The most common diagnoses were irritant contact dermatitis (26.7%) and allergic contact dermatitis (21.6%). No sensitisation to any of the baseline series allergens was significantly more frequent in female FCS with OD than in the two control groups. However, sensitisations to allergens which FCS are abundantly exposed to, including fragrances, preservatives, rubber ingredients and disinfectants, were most common.

Conclusions

FCS should be aware of the OD risk and prevention should be promoted.
Climate change is predicted to impact the global distribution and richness of pines (genus Pinus) by 2070
Authors: Salazar‐Tortosa Diego F. , Saladin Bianca , Castro Jorge , Rubio de Casas Rafael
Published: June 2024

Aim

Climate change is altering habitat suitability for many organisms and modifying species ranges at a global scale. Here we explored the impact of climate change on 112 pine species (Pinus), fundamental elements of Northern terrestrial ecosystems.

Location

Global.

Methods

We applied a novel methodology for species distribution modelling that considers uncertainty in climatic projections and taxon sampling, and incorporates elements of species' recent evolutionary history. We based our niche calculations on climate and soil data and computed projections across multiple algorithms and IPCC scenarios, which were ensembled into one single suitability map. We then used phylogenetic methods to account for recent evolution in climatic requirements by estimating the evolution of climatic niche. Edaphoclimatic and evolutionary analyses were then combined to calibrate the projections in areas showing high uncertainty. We validated our models using naturalized occurrences of invasive pine species.

Results

Our models predicted that by 2070, most pine species (58%) might face important reductions of habitat suitability, potentially leading to range losses and a decrease in species richness, particularly in some regions such as the Mediterranean Basin and South North America, albeit migration might mitigate these shifts in some cases. In contrast, our projections showed increased habitat suitability for approx. 20% of species, which may undergo range expansions under climate change. Moreover, the consideration of recent evolutionary trends modified projected scenarios, decreasing range loss and increasing range expansion for some species. The independent validation endorsed our models for many species and the influence of recent evolution in some cases.

Conclusions

We predict that climate change will impose drastic changes in pine distribution and diversity across biogeographical regions, but the magnitude and direction of change will vary significantly across regions and taxa. Species‐level responses are likely to be influenced by regional conditions and the recent evolutionary history of each taxon.