bluuebunny/crossref_metadata_2025 huggingface dataset:
Does Modified Mediterranean and Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns Interact with Psychological Disorders on Sleep Quality and Quantity? YaHS-TAMYZ study
Authors: Sherafatmanesh Saeed , Madadizadeh Farzan , Hosseinzadeh Mahdieh , Mohammadi Mohammad , Mirzaei Masoud , Khosravi-Boroujeni Hossein , Salehi-Abargouei Amin
Published: October 2023

BackgroundThe separate relationship between dietary food intake and psychiatric illnesses on individuals' sleep has been discovered in previous investigations. However, it is yet unknown how these variables combine to affect the quantity and quality of sleep.ObjectiveThe purpose of the present cross-sectional study was to assess the possible interaction between Dietary Approaches to Stop Hypertension (DASH) and Modified Mediterranean (mMED) dietary patterns (DPs) and psychological ailments (PAs) on sleep quality and duration among Iranian adults, Yazd, Iran.Methods and Materials:Baseline data from a large Iranian cohort study (Yazd Health Study: YaHS-TAMYZ) were used in the current investigation. A validated food frequency questionnaire was utilized to obtain participants' dietary consumption. The adherence level of a priori DPs was calculated according to the earlier scientific literature. The depression, anxiety, and stress scale-21 (DASS-21) questionnaire was employed to assess PAs. To gather information regarding the individuals' sleep quality and duration, a nocturnal sleep questionnaire and short version of the Pittsburgh questionnaire were utilized. Finally, the multivariable adjusted binary logistic regression test was used to examine the interaction between DPs and PAs on sleep quality and duration.ResultsParticipants with the greatest adherence to the mMED DP and with severe depression had significantly lower odds of "low sleep quality" than those without depression signs and the lowest imitation of the diet (P for interaction: 0.039).ConclusionA Mediterranean-like diet might help those with severe depression among people with severe depression. Prospective investigations are needed to confirm this finding.Keywords: Mediterranean; Dietary Approaches To Stop Hypertension; Diet; Depression; Anxiety; Stress; Psychological Well-Being; Sleep
Quantitative trait loci detection for three tiller-related traits and the effects on wheat (Triticum aestivum L.) yields
Authors: Cai Yibiao , Zhou Xiaohan , Wang Chenyang , Liu Aifeng , Sun Zhencang , Li Shihui , Shi Xinyao , Yang Shuang , Guan Yuxiang , Cheng Jiajia , Wu Yongzhen , Qin Ran , Sun Han , Zhao Chunhua , Li Junming , Cui Fa
Published: October 2023

Tiller-related traits play an important role in determining the yield potential of wheat. Therefore, it is important to elucidate the genetic basis for tiller number when attempting to use genetic improvement as a tool for enhancing wheat yields. In this study, a quantitative trait locus (QTL) analysis of three tiller-related traits was performed on the recombinant inbred lines (RILs) of a mapping population, referred to as KJ-RILs, that was derived from a cross between the Kenong 9204 (KN9204) and Jing 411 (J411) lines. A total of 38 putative additive QTLs for spike number per plant (SNPP), maximum tiller number (MTN), and ear-bearing tiller rate (EBTR) were detected in eight different environments. Among the QTLs, three major and stable QTLs were first documented herein. The genetic effects of two co-located major and stable QTLs, i.e., qSnpp-KJ-5D.1 and qMtn-KJ-5D, for yield-related traits were characterized. These beneficial alleles were selected for wheat breeding programs, and their potential for future application in molecular breeding technology for yield improvement was evaluated. The candidate genes underlying qMtn-KJ-5D were predicted based on multi-omics data, and TraesKN5D01HG00080 was identified as a likely candidate gene. Overall, our results will help elucidate the genetic architecture of tiller-related traits and can be used to develop novel wheat varieties with high yields.
Delphi method applicability in drug foresight
Authors: Lintonen Tomi , Karjalainen Karoliina , Rönkä Sanna , Kotovirta Elina , Niemelä Solja
Published: October 2023

Background
The aim of the current study was to assess the accuracy of expert predictions, which were derived using a Delphi panel foresight study in 2010, on a variety of drug-related topics in Finland in 2020.
Methods
The material used to evaluate the accuracy of the predictions consists of published reports on statistics, survey results, official register data, wastewater analyses and official documents. Whenever possible, we used multiple information sources to ascertain possible changes related to the predictions.
Results
In 2010, the majority – but not all – of the experts accurately predicted an increase in drug use. Indeed, more people experimented with or used drugs, and more drug residues were found in wastewater monitoring. The experts also correctly predicted an increase in population-level approval of drug use, but this development has been rather slow. Contrary to predictions, there was no marked increase in the use of new synthetic drugs. However, the misuse of buprenorphine increased during the 2010s. In the drug market, unit prices were surprisingly stable over the ten-year period. There were no changes in legislation related to the legal status of drugs, as was foreseen by the experts. However, enforcement moved in the direction foreseen by the experts: more lenient measures have been taken against users. Drug care system reforms favored a combination of mental health and addiction care units between 2010 and 2020, as foreseen by the experts.
Conclusions
It seems to have been easier for the experts to foresee the continuation of existing trends, e.g., increasing use of drugs or widening approval of drugs, than to predict possible changes in the popularity of distinct groups of drugs such as new psychoactive substances (NPS). Even armed with the prediction that drug imports and wholesale would increasingly fall into the domain of organized crime, this undesirable development could not be stopped. Expert disagreement can also be seen as a valuable indication of uncertainty regarding the future. Foresight related to drug-related issues can produce relatively accurate and realistic views of the future at least up to ten years ahead.
Prediction of the success rates after endoscopic treatment of stone related ureteral stricture: Could the assesement of ureteral wall thickness play a role?
Authors: Sahin Cahit , Sobay Resul , Sinanoglu Orhun , Arikan Ozgur , Uslu Mehmet , Bicaklioglu Fatih , Sahinler Emre Burak , Yildirim Salih , Sarica Kemal
Published: October 2023

To evaluate the role of certain radiological parameters in predicting the success of endoscopic treatment in ureteral strictures formation.
51 adult patients with ureteral stricture formation (< 1cm) after ureteroscopic removal of proximal ureteric stones were included and in addition to stone and patient parameters, radiological parameters including ureteral wall thickness (UWT) at the impacted stone site were also measured on computed tomography (CT) images. Patients were evaluated in two groups: Group 1: Patients in whom a endoscopic treatment was successful and Group 2: Patients in whom other approaches were needed after endoscopic treatment failure. The possible relationship between the UWT values and other radiological parameter with the outcomes of endoscopic treatment was comparatively evaluated.
All patients developed ureteral stricture due to upper ureteral stones with ureteroscopic laser disintegration. No significant difference was present regarding the patient characteristics. Mean UWT value assessed at the treated stone site was significantly higher in cases unresponsive to endoscopic treatment with values of 2.77±1.03 mm and 4.25±1.32 mm in Group 1 and 2 respectively. A cut off value 3.55 mm for UWT was found to be highly predictive for endoscopic treatment failure.
Our current results indicated that assessment of UWT value at the obstructing stone could be helpful enough to predict the likelihood of failure following endoscopic management of strictures with high sensitivity and specifity. Evaluation of this particular parameter could let the endourologists to look for more rational treatment alternatives with necessary mesaures taken on time.
Clinical comparative study of transumbilical laparoendoscopic single-site surgery versus conventional laparoscopic surgery for patients with fallopian pregnancy
Authors: Han Ling , Zhang Bingyi
Published: October 2023

Object:
The Body Image Questionnaire (BIQ) score was introduced to objectively evaluate the aesthetic effects of single and porous laparoscopic salpingectomy.
Methods:
A total of 40 patients undergoing single-port laparoscopic salpingectomy for fallopian pregnancy admitted to People's Hospital of China Three Gorges University from January 2019 to July 2021 were enrolled, and 38 patients undergoing conventional laparoscopic surgery for the same disease were selected as the control group. Visual Analogue Scale (VAS) at 24 hours after surgery and BIQ were used to evaluate patients' body satisfaction and cosmetic satisfaction of postoperative wound scar.
Results:
here was no significant difference in the mean age, Body mass index (BMI), history of previous abdominal surgery, pelvic adhesion, Visual analogue score of pain at 24 h postoperatively, postoperative pain drug use, and Body Image Scale（BIS）score between the two groups. Two groups of patients with postoperative fever, intraoperative blood loss, postoperative 24 hours Hb decreased, total length of hospital stay, there was no statistically significant difference. However, there were statistical differences between the two groups in postoperative cosmetic score, total hospitalization cost, and operation time.
Conclusion:
Single port laparoscopic salpingectomy is safe and feasible and has certain advantages inincision beauty and incision pain.
Dose Dependent Tranexamic Acid Blunting of Penumbral Leukocyte Mobilization and Blood Brain Barrier Permeability Following Traumatic Brain Injury: An In-vivo Murine Study
Authors: Culkin Matthew C , Bele Priyanka , Georges Anastasia P , Carlin Patricia Santos , Niziolek Grace , Kaplan Lewis J , Smith Douglas H , L Jose L Pascual
Published: October 2023

Background. Early post-TBI Tranexamic acid (TXA) may reduce blood-brain-barrier (BBB) permeability, but it is unclear if this effect is fixed regardless of dose. We hypothesized that post-TBI TXA demonstrates a dose dependent reduction of in vivopenumbral leukocyte (LEU) mobilization, BBB microvascular permeability, and enhanced neuroclinical recovery.
Study Design. CD1 male mice (n=40) were randomized to TBI by controlled cortical impact (Injury, I) or sham craniotomy (S), followed by IV bolus of either saline (placebo, P) or TXA (15, 30, or 60mg/kg). At 48h, in-vivo pial intravital microscopy (IVM) visualized live penumbral BBB microvascular LEUs and albumin leakage. Neuroclinical recovery was assessed by Garcia Neurological Test (GNT) scores and animal weight changes at 24 and 48h after injury.
Results.I+TXA60 reduced live penumbral LEU rolling compared to I+P (p<0.001) and both lower TXA doses (p=0.017 vs. I+TXA15, p=0.012 vs. I+TXA30). LEU adhesion was infrequent and similar across groups. Only I+TXA60 significantly reduced BBB permeability compared to I+P (p=0.004). All TXA doses improved GNT scores relative to I+P at both 24 and 48h (p<0.001 vs. I+P for all at both time points). Mean 24-hour body weight loss was greatest in I+P (-8.7±1.3%) and lowest in TXA15 (-4.4±1.0%, p=0.051 vs. I+P).
Conclusion. Only higher TXA dosing definitively abrogates penumbral LEU mobilization, preserving BBB integrity post-TBI. Some neuroclinical recovery is observed even with lower TXA dosing. Better outcomes with higher dose TXA after TBI may occur secondary to LEU-mediated penumbral cerebrovascular inflammation blunting.
Protective effects of metformin against doxorubicin-induced hepatoxicity in rats
Authors: lal-Shahsavar Shabnam , Zolbanin Naime Majidi , Jafari Abbas , Ghasemnejad-Berenji Morteza
Published: October 2023

Purpose
Doxorubicin (DOX) is one of the most commonly prescribed anti-cancer drugs. However, DOX-induced hepatotoxicity is a dose-limiting side effect. This study aimed to clarify the potential protective effects of metformin on DOX-induced hepatotoxicity in rats.
Methods
The animals were divided into six groups (n=6 each): Control Group, DOX group, metformin 200 mg/kg group, DOX + metformin 50 mg/kg group, DOX + metformin 100 mg/kg group, and DOX + metformin 200 mg/kg group. Hepatic injury was induced by a single intraperitoneal injection of DOX (20mg/kg). The activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) in serum were determined. Furthermore, the hepatic histopathological changes were evaluated. In order to identify the markers of oxidative stress, the level of malondialdehyde (MDA) and the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue were measured.
Results
Results showed that DOX provoked a marked elevation in ALT, AST, and ALP serum levels. In addition, oxidative stress was significantly boosted in DOX-treated rats compared to control rats. All these were abolished with the metformin administration. Histological examination also showed that metformin could significantly reduce DOX-induced alterations. The most prominent effect was observed by high-dose metformin.
Conclusion
This study showed that metformin could prevent doxorubicin-induced hepatoxicity.
Controllable preparation of Zeolite-P/calcined diatomite with MgCl2
Authors: Guo Zhengzheng , Ren Zijie , Gao Huimin , Guan Junfang , Li Peiyue , Zheng Renji , Yin Hang , Chen Zhijie
Published: October 2023

Developing highly efficient calcined diatomite (C-D)-based filter aids with excellent adsorption performance is of great significance. Herein, Zeolite-P was successfully synthesized on the surface of C-D through hydrothermal modification with NaOH and MgCl2 as efficient morphology control agents. The optimal Zeolite-P/C-D material perfectly retained the diatomite structure and showed a whiteness of 83.36% and a high specific surface area of 237.47 m2/g, leading to an excellent adsorption capacity for methylene blue trihydrate (MB) of 125.46 mg/g and a good permeability of 0.43 darcy. The porous fibrous microspheres Zeolite-P was synthesized on the surface of C-D under controlled conditions to improve the adsorption performance of Zeolite-P/C-D material. By developing diatomite-based composites for filter aids applications, this study paves the way for the comprehensive and efficient utilization of low-cost diatomite resources.
Genetic dissection and identification of stripe rust resistance genes in the wheat cultivar Lanhangxuan 121, a cultivar selected from a space mutation population
Authors: Wu Qimeng , Liu Lei , Zhang Dandan , Li Chenchen , Nie Ruiqi , Duan Jiangli , Wan Jufen , Zhao Jiwen , Cao Jianghao , Liu Dan , Liu Shengjie , Wang Qilin , Zheng Weijun , Yao Qiang , Kang Zhensheng , Zhang Wentao , Du Jiuyuan , Han Dejun , Wang Changfa , Wu Jianhui , Li Chunlian
Published: October 2023

Stripe rust is a devastating disease of wheat worldwide. Chinese wheat cultivar Lanhangxuan 121 (LHX121), selected from an advanced line L92-47 population that had been subjected to space mutation breeding displayed a consistently higher level of resistance to stipe rust than its parent in multiple field environments. The aim of this research was to establish the number and types of resistance genes L92-47 and LHX121 using separate segregating populations. The first population developed from a cross between LHX121 and susceptible cultivar Xinong 822 comprised 278 F2:3 lines. The second validation population comprised 301 F2:3 lines from a cross between L92-47 and susceptible cultivar Xinong 979. These lines were evaluated for stripe rust response at three sites during the 2018-2020 cropping season. Affymetrix 660K SNP arrays were used to genotype the lines and parents. Inclusive composite interval mapping detected QTL QYrLHX.nwafu-2BS, QYrLHX.nwafu-3BS, and QYrLHX.nwafu-5BS for resistance in all three environments. Based on previous studies and pedigree information, QYrLHX.nwafu-2BS and QYrLHX.nwafu-3BS were likely to be Yr27 and Yr30 that are present in the L92-47 parent. QYrLHX.nwafu-5BS (YrL121) detected only in LHX121 was mapped to a 7.60 cM interval and explained 10.67-22.57% of the phenotypic variation. Compared to stripe rust resistance genes previously mapped to chromosome 5B, YrL121 might be a new adult plant resistance QTL. Further, there were a number of variations signals using 35K SNP array and differentially expressed genes using RNA-seq between L92-47 and LHX121 in the YrL121 region, indicating that they probably impair the presence and/or function of YrL121.
Fluctuating selection at work: Estimating the firms’ fitnesses from time series of their market caps and forecasting their future shares
Authors: Fort Hugo
Published: October 2023

Evolutionary economics has been useful to explain the nature of the processes of innovation, as well as providing useful heuristics for applied research. However, quantitative tests are rare and in general fail to capture the observed dynamics of firms in real markets. A main problem is how to estimate the fitnesses of companies. We present a quantitative implementation of fluctuating selection to explain and forecast the dynamics of firms’ market capitalizations (MC). We start by proposing a recipe to estimate the financial fitness of a company from its MC time series, which is completely analogous to the Malthusian fitness of evolutionary biology. Using Malthusian fitnesses in terms of MC implies that all companies, through their stocks, irrespective of their industry or sector, are competing for investors’ money. These fitnesses, in turn, allow to forecast the companies’ proportions of total MC through a natural selection equation. We validate the method using the daily MC of public-owned Fortune 100 companies across 2000–2021. This Fluctuating Selection from Market Capitalization (FSMC) formula is particularly accurate in forecasting the MC proportions of companies. It outperforms the geometric random walk stochastic benchmark for all forecasting instances across validation periods ranging from a month to a year.JEL codes: B52, C51, C52, C53, C63, G17
Prolonged corticosteroid regimen with slow monthly tapering course is effective for the initial episode of steroid sensitive nephrotic syndrome; Evidence from a Randomized control trial
Authors: Udupitikankanange Jayantha , Randula Sithira , Darshana Nuwan
Published: October 2023

Background
The benefits of prolonged steroid therapy in the initial episode Steroid Sensitive Nephrotic Syndrome (SSNS) has been challenged. This study was conducted to determine whether prolonged corticosteroid regimen for the initial episode of SSNS resulting in highly favorable results with slow monthly tapering course against prolonged regimen with steep dose reduction and rapid tapering course.
Methods
A randomized control trial was conducted among 65 children aged 1-12years with nephrotic syndrome after achieve remission with daily prednisolone for 28 days. They were randomized into two groups based on prednisolone regimen; Author Experimental Regimen (AER)(n = 32) and Kidney Disease Improving Global outcome (KDIGO)(n = 33) regimen. AER group (total 7 months) received a prolonged prednisolone regimen with slow monthly tapering course. KDIGO regimen group received prolonged regimen with steep dose reduction and rapid tapering course. Both groups were followed up to three years at 6-month, 12-month, 24 month and 36 months respectively.
Results
The mean (SD) duration of remission following the initial episode was significantly prolonged in the AER group compared to the KDIGO group (17.3 vs 8.4 months). Relapse rate, relative risk for relapse, cumulative relapse status and incidence of steroid dependence were statistically significantly very low in AER group. Children in AER group had lower risk to develop adverse events due to steroid therapy.
Conclusion
The prolonged corticosteroid regime with a slow monthly tapering course showed a highly favorable results for the initial episode of SSNS. Hence, AER is recommended to manage children with initial episode of SSNS to achieve better outcome.
The gut microbiota and psoriasis: A two-sample Mendelian randomization study Running title: Gut microbiota and psoriasis
Authors: Guo Chenqi , Li Junchen , Zhang Jianfeng , Xu Fan , Wang Yingdong , Gu Xiangru , Zhang Min , Zhang Yu
Published: October 2023

Background
Increasing evidence suggests an association between the gut microbiota and psoriasis, but the causal relationship between them is not yet clear.
Methods
To explore the relationship between the gut microbiome (GM) and psoriasis, a bidirectional dual-sample Mendelian randomization (MR) study was conducted. The genome-wide association study (GWAS) summary statistics of the gut microbiota and psoriasis were obtained from the most extensive GWAS database. We used maximum likelihood (ML), MR Egger regression, weighted median, inverse variance weighting (IVW), and weighted models to study the causal relationship between the gut microbiota and psoriasis. Then, sensitivity analyses such as level multiple validity analysis, Cochran’s Q test, and the retention method were used to evaluate the reliability of the results.
Results
MR analysis revealed that the class Mollicutes (OR = 1.003, 95% CI = 1.001–1.006, P = 0.004019), genus Lachnospiraceae FCS020 group (OR = 1.003, 95% CI = 1.000-1.005, P = 0.04076), and phylum Tenericutes (OR = 1.003, 95% CI = 1.001–1.006, P = 0.004019) were causally associated with an increased risk of psoriasis. The family Victivallaceae (OR = 0.998, 95% CI = 0.997-1.000, P = 0.005296) and order Pasteurellales(OR = 0.998, 95% CI = 0.996 -1.000, P = 0.047) were also linked to a decreased risk of psoriasis. The results of the sensitivity analysis were robust. There is no evidence of a reverse causal relationship from psoriasis to the identified bacterial taxa found in the results of reverse MR analysis results.
Conclusion: Our study comprehensively evaluated the potential causal relationship between the gut microbiota and psoriasis, demonstrating that specific gut microbiota can affect the development of psoriasis and providing new directions for future prevention and treatment of psoriasis.
Requirements Business Value and Test Case Attributes based Test Case Prioritization Using Deep Reinforcement Learning.
Authors: Khan Tamim Ahmed , Akhtar Zobia Jabeen
Published: October 2023

Testing is a cost-intensive process whereas regression testing is used for the purpose of finding out if there is a regression in a post-evolution or post-maintenance scenario. It is expensive to run all test cases for regression testing and therefore we require a test case selection strategy so that we may select a subset of test cases from a previously available set of all test cases. Test case prioritization is a mechanism that can be used as a test subset selection strategy for regression testing. We investigate how requirements priority and importance as well as test case parameters such as fault severity, fault count, and their inter-dependency can be used for proposing a reward function to improve results. We use a deep reinforcement learning approach to optimize or prioritize the test cases using our reward function. We make use of an off-policy, model-free, and value-based test case prioritization approach considering a deep Q-Network (DQN) agent and a reward system based on a business value of test cases that prioritize the test cases against those business values. We use performance metrics to measure the performance and effectiveness of our research. We have compared our results with the published research and conclude that the results achieved from our approach outperform the previously published results of state-of-the-art studies.
Scientific Analysis of Two Compound Eye Beads Unearthed in Hejia Village, Zhouling
Authors: Li Jingyu , Sun Feng , Ha Wenhui , Zhai Haihong , Zhai Congwen
Published: October 2023

Glass compound eye beads is the exquisite embodiment of the glass making technology of ancient craftsmen, and is a example of the cultural exchange between China and the West in the Warring States Period. In the existing scientific research of compound eye beads, only the chemical element composition and fabtication process are discussed, and the weathering mechanism of this kind of objects are rarely discussed. In this study, two dots & mesh beads with seriously weathered surfaces were unearthed in Hejia village, Zhouling. Micromorphology, X-ray fluorescence spectroscopy (XRF) and microscopic laser Raman spectroscopy were used for non-destructive testing to analyze them. The results show that the two compound eye beads belong to the lead-barium silicate system. The substrate of the beads is glassy, the yellow weathered layer in is cerussite, the white weathered layer is barium sulfate and the blue weathered layer is walstromite. It is the first time that the walstromite has been found in the weathered layer of ancient glass. This study focused on the analysis of weathered layers of two compound eye beads, and inferred about their weathering mechanism. In order to provide data support for the subsequent protection of glass compound eye beads, it has certain scientific value.
Evaluation of Atrial Electromechanical Conduction Times and P- Wave Indices and Parameters in Children with Type-1 Diabetes Mellitus
Authors: Özde Şükriye , Aktüre Gülşah , Yavuzyılmaz Fatma , Arslanoğlu İlknur , Özde Cem , Kayapınar Osman , Kaya Adnan , Coşkun Gökhan , Sayın Ahmet Egemen
Published: October 2023

The aim of the study was to investigate the presence of signs of atrial cardiomyopathy, which is thought to be the main underlying cause of the physiopathology of atrial fibrillation (AF) in children with type 1 diabetes mellitus (T1DM). The study analysed echocardiographic atrial electromechanical conduction times (AEMct), P-terminal force in lead V1 (PTFV1), an electrocardiographic index not previously evaluated in the paediatric population, and a selection of P-wave parameters (P-WPs). This was a cross-sectional, observational study involving 105 children diagnosed with T1DM and 101 healthy children with comparable characteristics. P-WPs were evaluated through electrocardiography, and AEMct were assessed using echocardiography in each patient. A statistical comparison was made of all resultant data. PTFV1, P-wave dispersion (P-Wdi) and electrocardiogram time from P-wave onset to lateral mitral annular late diastolic peak velocity (PA-lateral) in the diabetes group, both in the univariate model (0.99 ± 0.90 vs 3.32 ± 2.36, p < 0.000; 75.4 ± 10.9 vs 79.1 ± 11. 2 p = 0.022; and 24.7 ± 11.6 vs 48.2 ± 14.4 p < 0.000; respectively) and in the multivariate model (Exp(B)/OR: 3.928, 95% CI: 2.339–6.596, p < 0. 001; Exp(B)/OR: 1.171, 95% CI: 1.109–1.236, p < 0.001; and Exp(B)/OR: 1.660, 95% CI: 1.265–1.236, p < 0.001; respectively) were significantly higher. A weak but statistically significant positive correlation was found between the mean HgA1c level and both P-Wdi (r = 0.204, p = 0.037) and inter-atrial electromechanical delay (r = 0.207, p = 0.044). The electrical deterioration of the atria may begin subclinically at a very early stage of T1DM that begins in childhood, even though the atria appear structurally normal. The results of this study indicate that T1DM in childhood could potentially be linked to an amplified threat of AF development.
The Effect of Blood Purification Combined with Psychological Care on Children with Amanita Phalloides Poisoning: A Retrospective Study
Authors: Yang Meng , Zong Yixuan , Zhu Guangfen , Cheng Xuejin , Liu Yunna , Zi Minxue , Su Xuan , Zhang Fan , Liu Kai , Zhang Lifang
Published: October 2023

Background: Amanita phalloides poisoning is a life-threatening condition that can cause acute liver failure, coagulopathy, and multi-organ failure. Blood purification treatment and nursing care are essential for managing this poisoning. However, there is a lack of systematic comparison of the effects of different blood purification methods and nursing techniques on the prognosis and quality of life of patients with Amanita phalloides poisoning.
Methods: We conducted a retrospective observational study of 43 patients with Amanita phalloides poisoning who were admitted to the PICU of a tertiary hospital from January 2019 to December 2021. We collected and analyzed their demographic and biochemical data, blood purification treatment, nursing method, and outcome. We also assessed the psychological state and quality of life of 3-year-old children using the Child Behavior Checklist (CBCL) before and after treatment.
Results: Blood purification treatment significantly improved the biochemical indicators and patient outcomes. Intensive and psychological care assistance reduced the average recovery time and increased the proportion of improved patients. Psychological care assistance also improved the psychological state of 3-year-old children. No significant differences in biochemical indicators existed between male and female patients before treatment. Prothrombin time and blood ammonia levels varied significantly by age before treatment.
Conclusions: Our study suggests that blood purification treatment effectively removes toxins and improves liver function and coagulation status in patients with Amanita phalloides poisoning. Intensive care and psychological care assistance can enhance the physical and mental health of the patients and promote their recovery. We recommend a comprehensive treatment and nursing program to improve patients' prognosis and quality of life with Amanita phalloides poisoning.
Network Attack Knowledge Reasoning Model based on Graph Convolutional Neural Networks
Authors: Ren WeiWu , Lei Ying , Hong Yu , Song XinTong , Yao JinYu , Du YaZhou , Li WenJuan
Published: October 2023

To address the challenge of analyzing large-scale penetration attacks involving complex multiple relations and multi-hop pathways, we have proposed an attack knowledge inference model based on graph convolutional neural networks. The core concept of this model involves obtaining knowledge embeddings related to CVE, CWE, and CAPEC to construct attack context feature data and relationship matrices. Subsequently, we utilize a graph convolutional neural network model for attack classification and employ the CONVE model for attack inference within the same attack category. Research results have shown that this approach outperforms other inference methods in terms of both inference accuracy and efficiency. Through improvements to the graph convolutional neural network model, we have significantly enhanced the accuracy and generalization capability of the attack classification task. Furthermore, we have introduced the use of the CONVE model for attack inference tasks for the first time, and experimental results demonstrate that the CONVE model can infer implicit relationships between CVE-CVE, CVE-CWE, and CVE-CAPEC. This method allows for a deeper learning and understanding of entity relationships within the attack knowledge graph and even aids in revealing certain hidden connections.
Short-term extinction predicted by population viability analysis for a Neotropical salt marsh endemic bird
Authors: Sandretti-Silva Giovanna , Vannucchi Fabio Stucchi , Teixeira Larissa , Yeuw Tan Tjui , Mori Gustavo Maruyama , Reinert Bianca Luiza , Bornschein Marcos Ricardo
Published: October 2023

Salt marshes pose challenges for the birds that inhabit them, including high rates of nest flooding, tipping, and predation. The impacts of rising sea levels and invasive species further exacerbate these challenges. To assess the urgency of conservation and adequacy of new actions, researchers and wildlife managers may use population viability analyses (PVAs) to identify population trends and major threats. We conducted PVA for Formicivora acutirostris, which is a threatened neotropical bird species endemic to salt marshes. We studied the species’ demography in different sectors of an estuary in southern Brazil from 2006–2023 and estimated the sex ratio, longevity, productivity, first-year survival, and mortality rates. For a 133-year period, starting in 1990, we modeled four scenarios: 1) pessimistic and 2) optimistic scenarios, including the worst and best values for the parameters; 3) a baseline scenario, with intermediate values; and 4) scenarios under conservation management, with increased recruitment and/or habitat preservation. Projections indicated population decline for all assessment scenarios, with a 100% probability of extinction within 34 years in the pessimistic scenario and no extinction in the optimistic scenario. The conservation scenarios indicated population stability with 16% improvement in productivity, 10% improvement in first-year survival, and stable carrying capacity. The disjunct distribution of the species, with remnants concentrated in a broad interface with arboreal habitats, may seal the population decline by increasing nest predation. The species should be considered conservation dependent, and we recommend assisted colonization, predator control, habitat recovery, and ex situ conservation.
Equality, Diversity and Inclusion: A Case for Public Procurement Bid Disputes Management In Kenya
Authors: Nyathore Paul Mathenge , Wainaina Gituro , Awino Zachary Bolo , Kariuki James Thuo
Published: October 2023

The United Nations Sustainable Development Goals (SDGs) advocate for equality, diversity and inclusion. The SDG 5 promote gender equality while SDG 10 advocate for reduced inequalities. Public procurement has grown to become a critical means of helping governments achieve political, economic, social, technological, environmental, and even legal policy objectives. The objective of this paper was to assess equality, diversity and inclusion in management of bid disputes in Kenya. Content analysis of all the bid dispute cases heard and determined by Public Procurement Administrative Review Board (PPARB) between 2011 and 2020 was conducted. In addition, request for review procedures and guiding laws were also reviewed. Analysis of descriptive data supported by deductive reasoning was thereafter conducted. It was established that request for review filing procedures in Kenya do not favour would be applicants especially those falling in the categories of youth, women, people living with disabilities and MSMEs. The paper has made contribution to body of knowledge regarding management of public procurement bid disputes in Kenya. The paper recommended that policy review be initiated to promote equality, diversity and inclusion in management of bid disputes.
The combination of elesclomol and Cu2+ can inhibit the growth of colon cancer cells by targeting FDX1
Authors: Yu Jing , Peng Yuanhong , Wang Kang , Xu Qihuan , Li Haibin , Lu Yan , Ouyang Manzhao
Published: October 2023

Background
Colon adenocarcinoma (COAD) is the predominant histological type of colon cancer. Elesclomol, a unique copper ion carrier, is considered a potential anticancer drug and has been the subject of a series of clinical trials. FDX1 is the intended target of elesclomol and is believed to be a key regulatory factor in copper-mediated cell death. Through its specific targeting of FDX1, ES-Cu can lead to a reduction in Fe-S stability, potentially enabling more precise tumor destruction. However, further research is still needed regarding the use of elesclomol in the treatment of colon adenocarcinoma.
Methods
Through bioinformatics analysis, this study aims to explore the molecular expression, clinical relevance, and prognostic significance of FDX1 in COAD Additionally, based on in vitro and in vivo experiments, the therapeutic value of elesclomol in the treatment of colon adenocarcinoma will be investigated.
Result
The expression of FDX1 is significantly different between COAD and normal tissues. Patients with high expression of FDX1 tend to have better prognosis compared to those with low expression. FDX1 shows high sensitivity and specificity in diagnosing colon cancer. Immunohistochemical analysis suggests a strong correlation between FDX1 and various immune cells and immune checkpoints. TIDE scoring also indicates that patients with high FDX1 expression levels are more responsive to immune therapy. Furthermore, both in vitro and in vivo experiments have demonstrated that the combination of elesclomol and Cu2 + efficiently inhibits the growth of colon cancer cells, and the safety profile of this treatment approach is acceptable. Lastly, real-time quantitative PCR (qRT-PCR) experiments on colon cancer cell lines and animal tumor models have shown that elesclomol upregulates the expression level of FDX1.
Conclusion
The combination of elesclomol and Cu2 + can inhibit the growth of colon cancer cells by targeting FDX1.
Investigation of geomagnetic field variations in search of seismo-electromagnetic emissions associated with earthquakes in subduction zone of Andaman-Nicobar, India
Authors: Prajapati Rahul , Arora Kusumita
Published: October 2023

The study of seismo-electromagnetic emissions has the potential to provide new insights into the physics of seismic activity and improve our ability to monitor and predict earthquakes and other geophysical events. In this study, we examine one year of ground based geomagnetic data during March-2019 to April − 2020 from the Andaman subduction zone for signatures related to lithospheric processes. We focus on anomalous signatures in the vertical component of geomagnetic field after removing the global and seasonal effect from the data. We have also scanned for corresponding signatures in the polarization ratios estimated from spectral density in ULF range. Over the duration of one year, we noted an 80% enhancement in polarisation ratios and 67% deviations in diurnal ratios average 18 days before of earthquake events. Apart this, the significant enhances in diurnal and polarization ratio are successfully correlated with 11 out of 14 earthquakes shows an approximately 78 percent success ratio of present study.
Characteristics of Pseudophakic Retinal Detachment and Risk Factors of Recurrence
Authors: Gibelalde Ane , Pinar-Sueiro Sergio , Ibarrondo Oliver , Miguel Miguel Ruiz , Martínez-Soroa Itziar , Mendicute Javier
Published: October 2023

Background: The present study was designed to gain knowledge about the prognostic factors and evolution of pseudophakic retinal detachment (PRD) and to analyse the main characteristics of PRD, such as the mean time to retinal detachment following cataract surgery, as well as the clinical factors associated with the risk of recurrence and worse anatomical and functional outcomes.
Methods:This was a retrospective monocentric study of 330 patients with PRD who underwent surgery between 2012 and 2020.
All patients were pseudophakic andwere referred for retinal detachment surgery at Donostia University Hospital (Terciary Hospital, Spain).
Results: The mean age of the patients at the time of phacoemulsification was 63.06 ± 10.8 years, and 49.09% of them had moderate myopia [axial length (AL) (23.5-26.5 mm)]. In our series, macular detachment was evident in 69.09% (n=228) of the patients. The mean time that elapsed between phacoemulsification and PRD surgery was 4.04 ± 4.17 years, which was reduced by half in the event of surgical complications (2.24 ± 2.65). The rate of PRD was 28.79%. The anatomical results in terms of retinal reapplication were better with the combination of vitrectomy and scleral buckling (83.1% vs. 70.5%) (p=0,127) compared with vitrectomy. The variables associated with a higher risk of recurrence were male sex (hazardratio (HR)= 1.75), macular detachment (HR= 2.00) and the presence of proliferative vitreoretinopathy (PVR) (HR= 3.21).
Conclusions: PRD usually occurs within 4 years of phacoemulsification, although it may occur significantly earlier in the event of surgical complications. Macular involvement, PVR, and male sex are all associated with a higher risk of PRD recurrence.
Seedling responses to herbivory are driven by nutrient enrichment, grass competition and functional attributes
Authors: Bhadouria Rahul , Singh Rishikesh , Krishna Mayank , Tripathi Sachchidanand , Srivast Pratap , Raghubanshi Akhilesh Singh
Published: October 2023

The factors that affect the establishment and growth of tree seedlings include herbivory and competition for nutrients from the indigenous grasses. Grazers and browsers alter the dynamics of tree seedling establishment by directly devouring plant tissue, altering soil nutrient status (through fertilisation and trampling), and competing with grasses. Additionally, seedlings of the tree species with contrasting successional status and functional attributes may respond differently to these factors. In this study, we assessed the effects of different levels of soil nutrient availability, defoliation (mimicking herbivory), and grass competition on the seedlings of the four plant species with contrasting functional traits (N2-fixers versus non-N2-Fixers) and addressed whether there is any difference in the responses of individual species in terms of growth parameters (height, basal area, seedling biomass, relative growth rate), and leaf nutrient concentration. We observed that the defoliation significantly reduced the seedling survival. In the presence of grass, N2-fixing species fared better than non-N2 fixture species in terms of survival, which suggests that grass's competition for nutrients might lead to an increase in nodulation in N2-fixing species. Further, defoliated seedlings were able to increase their chances of survival when nutrient was supplemented. However, this effect was not observed when they were competing with grass for nutrients. The impact of defoliation was observed only for seedling height which reduced significantly; girth and dry weight were not found significantly different. Results of the study suggest that dry tropical seedlings are adapted to defoliation as they recover leaf function by increasing leaf number, leaf area, and leaf nutrients as well as stimulating compensatory branching. Higher relative growth response for height under nutrient addition and grass competition revealed that seedlings are taking advantage of nutrient supplements along with grass. Leaf N concentration was higher in N2 fixture species as compared to non-N2 fixture species. Although longer-term studies are needed to investigate the impacts of defoliation, nutrients, and grass competition, our findings give valuable information that can assist in the design of strategies for the restoration of India's dry tropical forests.
Managing hepatocellular carcinoma (HCC) across the stages: Efficacy and outcomes of stereotactic body radiotherapy (SBRT), a retrospective study
Authors: Mohamed Ahmed Allam , Berres Marie-Luise , Bruners Philipp , Lang Sven Arke , Trautwein Christian , Wiltberger Georg , Barabasch Alexandera , Eble Michael
Published: October 2023

Purpose:
Hepatocellular carcinoma (HCC) poses a unique challenge due to its predilection for developing a compromised liver, often limiting surgical options. Stereotactic body radiotherapy (SBRT) has emerged as a promising local treatment modality for HCC. This study aims to assess the effectiveness of SBRT in HCC patients unsuitable for surgery, focusing on local control, optimal radiation dosing, and prognostic factors.
Methods:
In this retrospective analysis, 52 HCC patients treated with SBRT were examined. The study assessed local control, progression-free survival (PFS), and overall survival (OS) while conducting dosimetric analyses. The relationship between mean liver dose and Child-Pugh Score (CPS) progression was also explored.
Results:
SBRT demonstrated a remarkable 95.7% freedom from local progression (FFLP) at 12 months. Notably, a D98% below 61 Gy (EQD2 α/ β 10) was associated with reduced FFLP (p-value 0.055). Logistic regression analysis revealed a dose-response relationship, with a 98% probability of tumor control at a prescribed radiation dose of 73.1 Gy. The study observed OS rates of 63.9% at one year and 32.8% at three years. Patients with portal vein tumor thrombus (PVTT) and larger tumors (≥ 37 cm³) experienced decreased PFS and OS. Multivariate analysis identified PVTT, larger tumor volume, and performance status as independent predictors of reduced OS. Notably, c-RILD was absent, but ncRILD occurred in 7.7% of patients. Regression analysis linked a mean EQD2 α/ β 3 dose to the liver with a 10% likelihood of ncRILD.
Conclusion:
SBRT offers a compelling option for achieving high local control and promising survival outcomes in HCC. The study supports a radiation dose range of 61-73.1 Gy, coupled with a mean liver dose under 12.6 Gy as EQD2, to achieve favorable FFLP rates with acceptable toxicity rates.
Homeowners’ Prioritization of Landscape Features Regarding Aesthetic, Environmental, Financial, and Psychological Benefits
Authors: Knuth Melinda , Wei Xuan , Zhang Xumin , Khachatryan Hayk
Published: October 2023

Maintaining and caring for residential landscapes is a crucial aspect of homeownership in the United States. For homeowners in the United States, residential lawns represent a significant economic investment, signal their social commitments, and reflect their personal characters. To investigate the differences in Florida homeowners’ priorities regarding residential landscape features, an online survey of 1220 homeowners was conducted. Four different groups of homeowners were identified based on their perceived importance of the four landscape features, namely, environmental, financial, aesthetic, and psychological benefits. Factors such as environmental and financial attitudes and social norms influencing homeowners’ decision-making were examined. The findings revealed that homeowners’ knowledge of landscaping practices and environmental attitudes impact their prioritization regarding landscape features.
Extremal stringy black holes in equilibrium at first order in $\alpha'$
Authors: Ortín Tomás , Ruipérez Alejandro , Zatti Matteo
Published: October 2023

We compute the first-order \alpha'α′ corrections to well-known families of heterotic multi-center black-hole solutions in five and four dimensions. The solutions can be either supersymmetric or non-supersymmetric, depending on the relative sign between two of the black-hole charges. For both cases, we find that the equilibrium of forces persists after including the \alpha'α′ corrections, as the existence of multi-center solutions free of unphysical singularities shows. We analyze the possibility of black-hole fragmentation.
The nexus between female directors and corporate cash holdings: Evidence from Indonesia
Authors: Sutrisno Bambang , Jaharuddin Jaharuddin , Asni Gani Nur , Maulianza Medo , Sriminarti Nurul
Published: October 2023

In the last decade, gender diversity on boards or women in the boardroom has gained the attention of academics and practitioners. This paper aims to explore how women directors affect corporate cash holdings in Indonesia. This study utilizes data on Kompas 100 index firms for 2014–2021. A fixed-effect estimator is used to analyze data. The study reveals that female directors positively influence cash holdings. This finding remains robust when employing an alternative proxy for female directors and excluding observations during the COVID-19 period. Additionally, the findings indicate notable variations in cash holdings between companies with and without female directors. Regarding control variables, a firm’s cash holdings are negatively influenced by board size, leverage, company size, and net working capital. Firm profitability and growth opportunities positively influence cash holdings. This paper also documents that institutional ownership weakens the nexus between female directors and cash holding. The findings highlight that female directors hold higher amounts of cash because of their increased risk aversion. This study enriches the discussion on female directors and cash-holding levels in a developing country with a two-tiered board system.
AcknowledgmentsThis study is not funded by any funding agency.