bluuebunny/crossref_metadata_2025 huggingface dataset:
Video 1 from Complex Rab4-Mediated Regulation of Endosomal Size and EGFR Activation
Authors: Tubbesing Kate , Ward Jamie , Abini-Agbomson Raymond , Malhotra Aditi , Rudkouskaya Alena , Warren Janine , Lamar John , Martino Nina , Adam Alejandro P. , Barroso Margarida
Published: April 2023

Video S1. Rotating ROIs corresponding to 3D dSTORM in Figure 2A.
Supplementary Figures 1 - 12 from Role of WNT7B-induced Noncanonical Pathway in Advanced Prostate Cancer
Authors: Zheng Dali , Decker Keith F. , Zhou Tianhua , Chen Jianquan , Qi Zongtai , Jacobs Kathryn , Weilbaecher Katherine N. , Corey Eva , Long Fanxin , Jia Li
Published: April 2023

PDF file - 3153K, Figure S1. WNT7B is regulated by the AR in CRPC 22RV1 cells. Figure S2. TUNEL assays after WNT7B knockdown. Figure S3. Knockdown efficiency of WNT7B shRNA determined by RT-qPCR. Figure S4. WNT7B is required for 22RV1 cell growth. Figure S5. WNT7B is overexpressed in CRPC tumors. Figure S6. β-Catenin distribution in C4-2B cells. Figure S7. PKCα and PKCδ are direct AR target genes in C4-2B cells. Figure S8. WNT7B promotes osteoblast differentiation of ST2 and C3H10T1/2 cells. Figure S9. Insoluble WNT7B is bound to the cell membrane. Figure S10. Mouse ALP, BSP and GAPDH primers are specific for mouse genes. Figure S11. PC-produced WNT7B promotes ST2 osteoblast differentiation. Figure S12. PC-produced WNT7B promotes C3H10T1/2 osteoblast differentiation.
Supplementary Figures 1-3 from Akt Promotes Post-Irradiation Survival of Human Tumor Cells through Initiation, Progression, and Termination of DNA-PKcs–Dependent DNA Double-Strand Break Repair
Authors: Toulany Mahmoud , Lee Kyung-Jong , Fattah Kazi R. , Lin Yu-Fen , Fehrenbacher Brigit , Schaller Martin , Chen Benjamin P. , Chen David J. , Rodemann H. Peter
Published: April 2023

PDF file - 210K, API inhibits ionizing radiation-induced Akt phosphorylation/activation
Supplementary Figure 5 from EpCAM Modulates NF-κB Signaling and Interleukin-8 Expression in Breast Cancer
Authors: Sankpal Narendra V. , Fleming Timothy P. , Gillanders William E.
Published: April 2023

PDF file - 26K, Mutating IL-8 promoter at AP-1 and NF-kB binding ssites shows NF-kB is dominant player for IL-8 transcription
Supplementary Figure 4 from EpCAM Modulates NF-κB Signaling and Interleukin-8 Expression in Breast Cancer
Authors: Sankpal Narendra V. , Fleming Timothy P. , Gillanders William E.
Published: April 2023

PDF file - 27K, EpCAM and or IL-8 knockdown decreased matrigel invasion.
Supplementary Figure 3 from Analysis of mRNA Profiles after MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity
Authors: Gysin Stephan , Paquette Jesse , McMahon Martin
Published: April 2023

PDF file, 203K, Inhibition of ectopic cMYC expression by MEK inhibition.
Supplementary Figure 1 from Protein Kinase Casein Kinase 2–Mediated Upregulation of N-Cadherin Confers Anoikis Resistance on Esophageal Carcinoma Cells
Authors: Ko Hyeonseok , Kim Seongrak , Jin Cheng-Hao , Lee Eunjung , Ham Sunyoung , Yook Jong In , Kim Kunhong
Published: April 2023

PDF file - 71K, Western blot analysis for type of cadherin expressed in TE2, TE3, HCE4, and HCE7 (A) and for epithelial or mesenchymal markers and PKB/Akt activation in TE3 and HCE7 cells (B)
Supplementary Figures from Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress
Authors: Zimmerman Kristin M. , Jones Rebecca M. , Petermann Eva , Jeggo Penelope A.
Published: April 2023

Supplementary Figures PDF file - 558K, Figure S1. Growth parameters of 1BR3hTERT and U2OS cells. Figure S2. Additional images of BrdU replication recovery and �H2AX staining in HU-treated U2OS and/or 1BR3hTERT; description of DNA fibre assay. Figure S3. Depletion of ORC6 and CDC6 does not affect HU sensitivity in 1BR3hTERT. Figure S4. Selected concentrations of siRNA oligonucleotides do not significantly impair viability in additional cell lines selected. Figure S5. Assessment of HU treatment time required for complete HU-induced S phase damage induction
Supplementary Figure Legends from Diminished Origin-Licensing Capacity Specifically Sensitizes Tumor Cells to Replication Stress
Authors: Zimmerman Kristin M. , Jones Rebecca M. , Petermann Eva , Jeggo Penelope A.
Published: April 2023

Supplementary Figure Legends PDF file - 101K, Legends for Supplementary Figures S1-5
Supplementary Figure 1 from Migfilin Regulates Esophageal Cancer Cell Motility through Promoting GSK-3β–Mediated Degradation of β-Catenin
Authors: He Huan , Ding Fang , Li Yi , Luo Aiping , Chen Hongyan , Wu Chuanyue , Liu Zhihua
Published: April 2023

PDF file - 91K
Supplemental Figure Legend from Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
Authors: Newman Erika A. , Lu Fujia , Bashllari Daniela , Wang Li , Opipari Anthony W. , Castle Valerie P.
Published: April 2023

Legend for Supplemental Figures
Figure S4 from Kinetic Characterization of ASXL1/2-Mediated Allosteric Regulation of the BAP1 Deubiquitinase
Authors: Peng Hongzhuang , Cassel Joel , McCracken Daniel S. , Prokop Jeremy W. , Sementino Eleonora , Cheung Mitchell , Collop Paul R. , Polo Alexander , Joshi Surbhi , Mandell Jacob P. , Ayyanathan Kasirajan , Hinds David , Malkowicz S. Bruce , Harbour J. William , Bowcock Anne M. , Salvino Joseph , Kennedy Eileen J. , Testa Joseph R. , Rauscher Frank J.
Published: April 2023

S4. Refinement of the mechanism for ASXL stimulation of BAP deubiquitinase activity.
Supplementary Figures 1-6 from Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells
Authors: Schnepp Patricia M. , Shelley Greg , Dai Jinlu , Wakim Nicole , Jiang Hui , Mizokami Atsushi , Keller Evan T.
Published: April 2023

Supplementary Figure 1: Cell outlier removal. Supplementary Figure 2: Gene Expression Profiles. Supplementary Figure 3: Technical Variation in DU145 clusters. Supplementary Figure 4: Upstream Regulator Analyses in Bulk Sequencing Samples. Supplementary Figure 5: Comparison of NUPR1 Target Gene Expression between Single Cell and Bulk Sequencing Samples. Supplementary Figure 6: NUPR1 necessary for docetaxel resistance in PC3 cells.
Supplementary Data 6 from Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma
Authors: Chen Xufeng , Wong Patty , Radany Eric H. , Stark Jeremy M. , Laulier Corentin , Wong Jeffrey Y.C.
Published: April 2023

PDF file - 66K, (A) Immunofluorescence analysis for RAD51 (red) and cyclin A (green) co-staining in U266B1 cells at indicated time point after IR; Nuclei were stained with DAPI (blue). (B) Flow Cytometry assays for BrdU-incorporation and cell cycle distribution in U266B1 and RPMI8226 cells
Supplemental Figure S3 from Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium
Authors: Youngblood Victoria , Wang Shan , Song Wenqiang , Walter Debra , Hwang Yoonha , Chen Jin , Brantley-Sieders Dana M.
Published: April 2023

Supplemental Figure S3: Inhibiting Slit activity rescues tumor cell-induced EphA2-deficient endothelial cell migration.
Supplementary Data 4 from Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma
Authors: Chen Xufeng , Wong Patty , Radany Eric H. , Stark Jeremy M. , Laulier Corentin , Wong Jeffrey Y.C.
Published: April 2023

PDF file - 197K, MM cells were pretreated with 200 nM of SAHA for 16 hours, followed by 6 Gy IR. Whole cell extracts were prepared at indicated time points after IR, and analyzed by western blot assay with respective antibodies. Anti-tubulin antibody was included as a loading control
Supplementary Data 1 from Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma
Authors: Chen Xufeng , Wong Patty , Radany Eric H. , Stark Jeremy M. , Laulier Corentin , Wong Jeffrey Y.C.
Published: April 2023

PDF file - 60K, Effects of SAHA on (A) IC50/IC90, and (B) acetylation of histone H4 (fold changes measured by densitometry for western blot signals) in Multiple Myeloma cells in vitro
Supplementary Figures S1-S4 from c-Src-p38 Mitogen-Activated Protein Kinase Signaling Is Required for Akt Activation in Response to Ionizing Radiation
Authors: Kim Min-Jung , Byun Joo-Yun , Yun Chang-Hwan , Park In-Chul , Lee Kee-Ho , Lee Su-Jae
Published: April 2023

Supplementary Figures S1-S4 from c-Src-p38 Mitogen-Activated Protein Kinase Signaling Is Required for Akt Activation in Response to Ionizing Radiation
Supplementary Figure 2 from Prometastatic NEDD9 Regulates Individual Cell Migration via Caveolin-1–Dependent Trafficking of Integrins
Authors: Kozyulina Polina Y. , Loskutov Yuriy V. , Kozyreva Varvara K. , Rajulapati Anuradha , Ice Ryan J. , Jones Brandon C. , Pugacheva Elena N.
Published: April 2023

Supplementary Figure 2. (A) Quantification of relative fluorescence intensity units (RFU) of ÃŸ1 integrin in BT459 and MDA-MB231LN cells as in (B); graph is mean RFU, % of siCon (assigned as 100%) +/-S.E.M; n=3, 15 cells/per treatment; one-way ANOVA with Dunnett's post-hoc analysis; ligand-bound: MDA-MD-231LN *p<0.023 (siCon/siN2 and N3), BT459 *p<0.0052 (siCon/siN2 and N3); ligand-free: p is not significant (ns). (B). Representative confocal images of MDA-MB-231 cells treated with siCon and siNEDD9 (N3) for 48h and stained with ÃŸ1 integrin (ligand-bound/extended and ligand-free/bent) (green) without permeabilization, DNA (blue); Dotted lines represent cell borders, insets-the enlarged areas of individual cells (white lines) of b1 integrin surface staining (left) or heatmaps of b1 integrin surface staining intesity (right) indicated by rectangles in the main panel. Scale bar, 10$m; (C). Quantification of relative fluorescence intensity units (RFU) of ligand-bound ÃŸ1 integrin in MDA-MB-453 and ZR75-1 cells with or w/o Nedd9-cDNA; graph is mean RFU, % of control (assigned as 100%) +/-S.E.M; n=3, 15 cells/per treatment; t-test: MDA-MB-453 and ZR75-1 *p<0.0001 (w/o Nedd9-cDNA/with Nedd9-cDNA). (D). Quantification of number of FITC-Col.I positive vesicles (%) co-stained with EEA1 or Rab7 in MDA-MB-435 cells cells incubated with FITC-collagen I and stained with anti-EEA1/or Rab7; normalized to control; 15cells/per staining; t-test, EEA1: *p<0.0001(w/o Nedd9-cDNA/with Nedd9-cDNA), Rab7: *p=0.0088 (w/o Nedd9-cDNA/with Nedd9-cDNA). (E-F). Confocal images of MDA-MB-231-siCon,-siN2) cells stained with anti-Integrin b1 active (12G10)
Supplementary Table S2 from PARP Inhibition Induces Enrichment of DNA Repair–Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells
Authors: Bellio Chiara , DiGloria Celeste , Foster Rosemary , James Kaitlyn , Konstantinopoulos Panagiotis A. , Growdon Whitfield B. , Rueda Bo R.
Published: April 2023

Supplementary Table S2: p-values of RT-PCR analysis of RAD51 gene family in CD133+ cells and CD133- CD117- cells FACS purified (Figure 6A and 6B).
Supplementary Figures from PARP Inhibition Induces Enrichment of DNA Repair–Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells
Authors: Bellio Chiara , DiGloria Celeste , Foster Rosemary , James Kaitlyn , Konstantinopoulos Panagiotis A. , Growdon Whitfield B. , Rueda Bo R.
Published: April 2023

Supplementary figures: SA, SB, SC, SD, SE, SF, SG and SH
Supplementary Figure 2 from TNF-α Induces Epithelial–Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism
Authors: Ho Ming-Yi , Tang Shye-Jye , Chuang Mei-Jen , Cha Tai-Lung , Li Jing-Yao , Sun Guang-Huan , Sun Kuang-Hui
Published: April 2023

PDF file-218K, Constitutive activation of GSK-3β led to a reduction in the TNF-α-mediated transformation, migration, and invasion of Caki-1 cells.
Table and Figure Legends from Stem Cell Marker Nestin Is Critical for TGF-β1-Mediated Tumor Progression in Pancreatic Cancer
Authors: Su Huei-Ting , Weng Ching-Chieh , Hsiao Pi-Jung , Chen Li-Hua , Kuo Tzu-Lei , Chen Yu-Wen , Kuo Kung-Kai , Cheng Kuang-Hung
Published: April 2023

PDF File - 33K, Legends for Table 1 and Figures 1-5.
Supplementary Figure 1 from TNF-α Induces Epithelial–Mesenchymal Transition of Renal Cell Carcinoma Cells via a GSK3β-Dependent Mechanism
Authors: Ho Ming-Yi , Tang Shye-Jye , Chuang Mei-Jen , Cha Tai-Lung , Li Jing-Yao , Sun Guang-Huan , Sun Kuang-Hui
Published: April 2023

PDF file-68K, TNF-α enhanced expression of MMP9 and E-cadherin repressors as well as tumorigenicity of renal cell carcinoma (RCC).
Supplementary document materials and methods from Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences
Authors: Kaymaz Yasin , Oduor Cliff I. , Yu Hongbo , Otieno Juliana A. , Ong'echa John Michael , Moormann Ann M. , Bailey Jeffrey A.
Published: April 2023

Detailed methods used in the study.
Supplementary Video 1 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer
Authors: Hu Xiaowen , Guo Jinyi , Zheng Lan , Li Chunsheng , Zheng Tim M. , Tanyi Janos L. , Liang Shun , Benedetto Chiara , Mitidieri Marco , Katsaros Dionyssios , Zhao Xia , Zhang Youcheng , Huang Qihong , Zhang Lin
Published: April 2023

AVI file - 5088K, let-7b inhibits breast cancer cell motility�individual cell motility.
Supplementary Figure Legend from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer
Authors: Hu Xiaowen , Guo Jinyi , Zheng Lan , Li Chunsheng , Zheng Tim M. , Tanyi Janos L. , Liang Shun , Benedetto Chiara , Mitidieri Marco , Katsaros Dionyssios , Zhao Xia , Zhang Youcheng , Huang Qihong , Zhang Lin
Published: April 2023

PDF file - 94K
Supplemental Figure 5 from Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075
Authors: Faivre Emily J. , Wilcox Denise , Lin Xiaoyu , Hessler Paul , Torrent Maricel , He Wei , Uziel Tamar , Albert Daniel H. , McDaniel Keith , Kati Warren , Shen Yu
Published: April 2023

AR-dependent prostate cancer cell lines are dependent on BET.
Supplementary Table 1 from The Unliganded Glucocorticoid Receptor Positively Regulates the Tumor Suppressor Gene BRCA1 through GABP Beta
Authors: Ritter Heather D. , Antonova Lilia , Mueller Christopher R.
Published: April 2023

PDF file - 55K
Supplementary Figures from Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene-Driven Non–Small Cell Lung Cancer
Authors: Burns Timothy F. , Dobromilskaya Irina , Murphy Sara C. , Gajula Rajendra P. , Thiyagarajan Saravanan , Chatley Sarah N.H. , Aziz Khaled , Cho Yoon-Jae , Tran Phuoc T. , Rudin Charles M.
Published: April 2023

Supplementary Figures PDF file - 3634K, S1 TWIST1 specific shRNAs suppress TWIST1 transcript and protein levels. S2 Mouse Twist1 can rescue the anti-proliferative effects of knockdown of human TWIST1 in A549 cells. S3 Growth inhibition by silencing TWIST1 is not p53-dependent in KRAS mutant NSCLC. S4 Growth inhibition by silencing TWIST1 is not p21-dependent in KRAS mutant NSCLC. S5 Growth inhibition by silencing TWIST1 is not dependent on induction of p27 in KRAS mutant NSCLC S6 Overexpression of SKP2 does not rescue loss of TWIST1 in KRAS mutant NSCLC. S7 Microarray analysis of three KRAS mutant NSCLC cell lines (H460, H727 and H358) six days after silencing of TWIST1 reveals a striking cell cycle arrest gene signature. S8 Enrichment plots after Gene Set Enrichment Analysis for A. ROSTY_CERVICAL_CANCER_PROLIFERATION_CLUSTER (left) CROONQUIST_IL6_DEPRIVATION_DN (middle) CHANG_CYCLING_GENES (right) B. KANG_DOXORUBICIN_RESISTANCE_UP C. BLUM_RESPONSE_TO_SALIRASIB DN (left) CROONQUIST_NRAS_SIGNALING_DN (right) D. FUJII_YBX1_TARGETS_DN following GSEA performed on shScram and shTWIST1 samples from three KRAS mutant cell lines (H460, H727 and H358) six days after TWIST1 knockdown samples (NOM p-values, FDR qvalues, and FWER p-values were all <0.001 for all gene sets)
Supplementary Table 3 from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Authors: Pirozzi Christopher J. , Carpenter Austin B. , Waitkus Matthew S. , Wang Catherine Y. , Zhu Huishan , Hansen Landon J. , Chen Lee H. , Greer Paula K. , Feng Jie , Wang Yu , Bock Cheryl B. , Fan Ping , Spasojevic Ivan , McLendon Roger E. , Bigner Darell D. , He Yiping , Yan Hai
Published: April 2023

Genes displaying more than 2-fold change among IDH1LSL:R132H/WT ad-GFP versus ad-Cre NSCs were selected for pathway analysis by DAVID.
Supplementary Fig. 4 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1
Authors: Indira Chandran Vineesh , Månsson Ann-Sofie , Barbachowska Magdalena , Cerezo-Magaña Myriam , Nodin Björn , Joshi Bharat , Koppada Neelima , Saad Ola M. , Gluz Oleg , Isaksson Karolin , Borgquist Signe , Jirström Karin , Nabi Ivan Robert , Jernström Helena , Belting Mattias
Published: April 2023

S4. Hypoxia induces resistance to Abraxane in SKBR3 cells.
Supplementary Figure 7 from SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK
Authors: Li Hua , Cai Qi , Wu Hong , Vathipadiekal Vinod , Dobbin Zachary C. , Li Tianyu , Hua Xiang , Landen Charles N. , Birrer Michael J. , Sánchez-Beato Margarita , Zhang Rugang
Published: April 2023

PDF file - 55K, Upregulation of HRK contributes to apoptosis induced by SUZ12 knockdown
Supplementary Figure 3 from SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK
Authors: Li Hua , Cai Qi , Wu Hong , Vathipadiekal Vinod , Dobbin Zachary C. , Li Tianyu , Hua Xiang , Landen Charles N. , Birrer Michael J. , Sánchez-Beato Margarita , Zhang Rugang
Published: April 2023

PDF file - 81K, Alterations of the apoptosis regulating genes in SUZ12 knockdown EOC cells
Supplementary Figure 1 from Environmental Estrogens Differentially Engage the Histone Methyltransferase EZH2 to Increase Risk of Uterine Tumorigenesis
Authors: Greathouse K. Leigh , Bredfeldt Tiffany , Everitt Jeffrey I. , Lin Kevin , Berry Tia , Kannan Kurunthachalam , Mittelstadt Megan L. , Ho Shuk-mei , Walker Cheryl L.
Published: April 2023

PDF file - 319K, Photomicrographs of uteri stained with either hematoxylin and eosin or calbindin D9K from VEH-, DES-, GEN-, or BPA-exposed females (1, 50 or 50mg/kg, respectively) sacrificed on PND 12, 6hrs after the final of three exposures (all photomicrographs were taken at 20X). The scale bar is 100 �m.
Supplementary Figure 1 from CPEB1 Regulates the Expression of MTDH/AEG-1 and Glioblastoma Cell Migration
Authors: Kochanek Dawn M. , Wells David G.
Published: April 2023

Supplementary Figure 1 PDF file - 62K,pCPEB1 is up-regulated in CNS1 cells
Supplementary Figures 1-7 from Inhibition of the Nedd8 System Sensitizes Cells to DNA Interstrand Cross-linking Agents
Authors: Kee Younghoon , Huang Min , Chang Sophia , Moreau Lisa A. , Park Eunmi , Smith Peter G. , D'Andrea Alan D.
Published: April 2023

PDF file - 581K
Supplementary Figure 5 from Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis
Authors: Maji Sayantan , Chaudhary Pankaj , Akopova Irina , Nguyen Phung M. , Hare Richard J. , Gryczynski Ignacy , Vishwanatha Jamboor K.
Published: April 2023

Organ tropism
Supplementary Figure 2 from Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis
Authors: Maji Sayantan , Chaudhary Pankaj , Akopova Irina , Nguyen Phung M. , Hare Richard J. , Gryczynski Ignacy , Vishwanatha Jamboor K.
Published: April 2023

Quantification of angiogenic response by exosomal AnxA2
Supplementary Figure 1 from Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis
Authors: Maji Sayantan , Chaudhary Pankaj , Akopova Irina , Nguyen Phung M. , Hare Richard J. , Gryczynski Ignacy , Vishwanatha Jamboor K.
Published: April 2023

Characterization of exosomal AnxA2
Supplementary Figure Legends 1-6 from KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling
Authors: Appleman Victoria A. , Ahronian Leanne G. , Cai JiuFeng , Klimstra David S. , Lewis Brian C.
Published: April 2023

PDF file - 93K
Supplementary Figure 2 from KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling
Authors: Appleman Victoria A. , Ahronian Leanne G. , Cai JiuFeng , Klimstra David S. , Lewis Brian C.
Published: April 2023

PDF file - 7.8MB, KRASG12D and BRAFV600E induce pancreatic tumors in an orthotopic model
Supplementary Table S1 from Luteinizing Hormone–Induced Up-Regulation of ErbB-2 Is Insufficient Stimulant of Growth and Invasion in Ovarian Cancer Cells
Authors: Warrenfeltz Susanne W. , Lott Stephen A. , Palmer Travis M. , Gray Judy C. , Puett David
Published: April 2023

Supplementary Table S1 from Luteinizing Hormone–Induced Up-Regulation of ErbB-2 Is Insufficient Stimulant of Growth and Invasion in Ovarian Cancer Cells
Supplementary Figure Legend from The Invasion Inhibitor Sarasinoside A1 Reverses Mesenchymal Tumor Transformation in an E-Cadherin–Independent Manner
Authors: Austin Pamela , Freeman Spencer A. , Gray Christopher A. , Gold Michael R. , Vogl A. Wayne , Andersen Raymond J. , Roberge Michel , Roskelley Calvin D.
Published: April 2023

PDF file - 56K
Supplementary Figure 2 from The Invasion Inhibitor Sarasinoside A1 Reverses Mesenchymal Tumor Transformation in an E-Cadherin–Independent Manner
Authors: Austin Pamela , Freeman Spencer A. , Gray Christopher A. , Gold Michael R. , Vogl A. Wayne , Andersen Raymond J. , Roberge Michel , Roskelley Calvin D.
Published: April 2023

PDF file - 1740K, Supplemental data demonstrating sarasinoside A1's effects on the invasion of various tumor cell types
Supplementary Data - Tables from Epigenetically Regulated Chromosome 14q32 miRNA Cluster Induces Metastasis and Predicts Poor Prognosis in Lung Adenocarcinoma Patients
Authors: González-Vallinas Margarita , Rodríguez-Paredes Manuel , Albrecht Marco , Sticht Carsten , Stichel Damian , Gutekunst Julian , Pitea Adriana , Sass Steffen , Sánchez-Rivera Francisco J. , Lorenzo-Bermejo Justo , Schmitt Jennifer , De La Torre Carolina , Warth Arne , Theis Fabian J. , Müller Nikola S. , Gretz Norbert , Muley Thomas , Meister Michael , Tschaharganeh Darjus F. , Schirmacher Peter , Matthäus Franziska , Breuhahn Kai
Published: April 2023

Supplementary Data - Tables
supplemental materials from Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis
Authors: Danoch Hila , Kalechman Yona , Albeck Michael , Longo Dan L. , Sredni Benjamin
Published: April 2023

supplemental materials and supplemental figure legends for publication
Supplemental figure 3 from Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane–Induced Death by AS101 via Inhibition of the VLA-4–IL10–Survivin Axis
Authors: Danoch Hila , Kalechman Yona , Albeck Michael , Longo Dan L. , Sredni Benjamin
Published: April 2023

Supplemental Figure S3. The T127 and Jurkat human T leukemic cells that do not secrete IL-10 are not sensitized by AS101 to Paclitaxel-induced death.
Supplementary Video 2 from Inhibition of Eg5 Acts Synergistically with Checkpoint Abrogation in Promoting Mitotic Catastrophe
Authors: Chen Yue , Chow Jeremy P.H. , Poon Randy Y.C.
Published: April 2023

AVI file - 565K
Supplementary Figure 1A from Kinin B2 Receptor Mediates Induction of Cyclooxygenase-2 and Is Overexpressed in Head and Neck Squamous Cell Carcinomas
Authors: Zhang Weiping , Bhola Neil , Kalyankrishna Shailaja , Gooding William , Hunt Jennifer , Seethala Raja , Grandis Jennifer R. , Siegfried Jill M.
Published: April 2023

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Supplementary Table S2 from EZH2 Loss Drives Resistance to Carboplatin and Paclitaxel in Serous Ovarian Cancers Expressing ATM
Authors: Naskou Johanna , Beiter Yvonne , van Rensburg Ruan , Honisch Ellen , Rudelius Martina , Schlensog Martin , Gottstein Julia , Walter Larissa , Braicu Elena I. , Sehouli Jalid , Darb-Esfahani Silvia , Staebler Annette , Hartkopf Andreas D. , Brucker Sara , Wallwiener Diethelm , Beyer Ines , Niederacher Dieter , Fehm Tanja , Templin Markus F. , Neubauer Hans
Published: April 2023

Table S2.
Supplementary Fig. S2 from Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer
Authors: Miyawaki Masayoshi , Yasuda Hiroyuki , Tani Tetsuo , Hamamoto Junko , Arai Daisuke , Ishioka Kota , Ohgino Keiko , Nukaga Shigenari , Hirano Toshiyuki , Kawada Ichiro , Naoki Katsuhiko , Hayashi Yuichiro , Betsuyaku Tomoko , Soejima Kenzo
Published: April 2023

Immunoblotting analysis of H3122-CER cells.
Supplementary Fig. S1 from Overcoming EGFR Bypass Signal-Induced Acquired Resistance to ALK Tyrosine Kinase Inhibitors in ALK-Translocated Lung Cancer
Authors: Miyawaki Masayoshi , Yasuda Hiroyuki , Tani Tetsuo , Hamamoto Junko , Arai Daisuke , Ishioka Kota , Ohgino Keiko , Nukaga Shigenari , Hirano Toshiyuki , Kawada Ichiro , Naoki Katsuhiko , Hayashi Yuichiro , Betsuyaku Tomoko , Soejima Kenzo
Published: April 2023

Efficacy of ALK-TKIs for Ba/F3 cells transduced with EGFR wild type.
Supplementary Methods from Glutathione S-Transferase Mu2 Suppresses Cancer Cell Metastasis in Non–Small Cell Lung Cancer
Authors: Tang Sheau-Chung , Wu Chih-Hsien , Lai Chien-Hung , Sung Wen-Wei , Yang Wan-Jung , Tang Lee-Chun , Hsu Chung-Ping , Ko Jiunn-Liang
Published: April 2023

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Supplementary Figure 2 from Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling
Authors: Tabusa Hana , Brooks Teresa , Massey Andrew J.
Published: April 2023

PDF file - 25K, Inhibition of proliferation of HCT116 colon carcinoma cells by PAK4 or PAK1 RNAi is independent of RAF/MEK/ERK signaling.
Supplementary Figure 1 from Knockdown of PAK4 or PAK1 Inhibits the Proliferation of Mutant KRAS Colon Cancer Cells Independently of RAF/MEK/ERK and PI3K/AKT Signaling
Authors: Tabusa Hana , Brooks Teresa , Massey Andrew J.
Published: April 2023

PDF file - 30K, Knockdown of PAK4 reduces the proliferation of mutant KRAS or BRAF colon carcinoma cells in vitro.
Supplementary Figure 1 from Multiple Functions of Sushi Domain Containing 2 (SUSD2) in Breast Tumorigenesis
Authors: Watson Allison P. , Evans Rick L. , Egland Kristi A.
Published: April 2023

PDF file - 4.4MB, Immunohistochemical analysis on cell lines using anti-SUSD2 antibody
Supplementary Figure Legends 1-2 from MUC1 Drives c-Met–Dependent Migration and Scattering
Authors: Horm Teresa M. , Bitler Benjamin G. , Broka Derrick M. , Louderbough Jeanne M. , Schroeder Joyce A.
Published: April 2023

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Supplementary Figure 2 from MUC1 Drives c-Met–Dependent Migration and Scattering
Authors: Horm Teresa M. , Bitler Benjamin G. , Broka Derrick M. , Louderbough Jeanne M. , Schroeder Joyce A.
Published: April 2023

PDF file - 1.9MB, A c-Met kinase inhibitor does not affect the viability of MDA-MB-231-MUC1 or MDA-MB-231-control cells: MTT proliferation assay comparing MDA-MB-231-MUC1 or MDA-MB-231-control cells that are untreated, treated with DMSO vehicle, or treated with SU11274, a selective c-Met kinase inhibitor
Supplementary Figure 1 from MYC-Induced Epigenetic Activation of GATA4 in Lung Adenocarcinoma
Authors: Castro Inês C. , Breiling Achim , Luetkenhaus Katharina , Ceteci Fatih , Hausmann Simone , Kress Sebastian , Lyko Frank , Rudel Thomas , Rapp Ulf R.
Published: April 2023

PDF file - 227K, GATA4 promoter analysis and in-vivo material used for next generation-sequencing
Supplementary Table 3C from Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
Authors: Lehman Heather L. , Van Laere Steven J. , van Golen Cynthia M. , Vermeulen Peter B. , Dirix Luc Y. , van Golen Kenneth L.
Published: April 2023

PDF file - 50K, Expression of RhoC GTPase Akt-consensus sequence mutants do not affect SUM149 viability. Propidium iodide (PI) based apoptosis assay with the expression of RhoAS73D phosphomimetic mutant. Cells were PI stained and fixed in 70% ethanol prior to FACS analysis. Transfected cells are compared to either vector transfected control or mock transfectants (UT)
Supplementary Table 1 from Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
Authors: Lehman Heather L. , Van Laere Steven J. , van Golen Cynthia M. , Vermeulen Peter B. , Dirix Luc Y. , van Golen Kenneth L.
Published: April 2023

PDF file - 19K, Inflammatory and non-inflammatory breast cancer patient PCR and Affymetrix data sets
Supplementary Figure 2B from Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
Authors: Lehman Heather L. , Van Laere Steven J. , van Golen Cynthia M. , Vermeulen Peter B. , Dirix Luc Y. , van Golen Kenneth L.
Published: April 2023

PDF file - 40K, Inhibition of Akt1 and Akt2 does not significantly affect cell viability or proliferation. Propidium iodide (PI) based apoptosis assay with the inhibition of Akt1 or Akt2 using siRNA in IBC and nIBC cells. Cells were PI stained and fixed in 70% ethanol prior to FACS analysis
Supplementary Figure 3 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Authors: Abdollahi Pegah , Vandsemb Esten N. , Hjort Magnus A. , Misund Kristine , Holien Toril , Sponaas Anne-Marit , Rø Torstein B. , Slørdahl Tobias S. , Børset Magne
Published: April 2023

Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 3A, 3B, 3C and 3D. The image scanner Image J was used to compare the density of bands in each blot.
Supplementary Figure 2A from Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
Authors: Lehman Heather L. , Van Laere Steven J. , van Golen Cynthia M. , Vermeulen Peter B. , Dirix Luc Y. , van Golen Kenneth L.
Published: April 2023

PDF file - 83K, Inhibition of Akt1 and Akt2 does not significantly affect cell viability or proliferation. MTT proliferation assay after depletion of Akt1 or Akt2 using siRNA in IBC and nIBC cells demonstrates no significant difference in cell proliferation upon treatment
Supplementary Figure 2 from Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3
Authors: Abdollahi Pegah , Vandsemb Esten N. , Hjort Magnus A. , Misund Kristine , Holien Toril , Sponaas Anne-Marit , Rø Torstein B. , Slørdahl Tobias S. , Børset Magne
Published: April 2023

Densitometric quantification of Western blot bands. Each graph shows the ratio between expression of protein of interest and its GAPDH loading control for Figures 2A, 2B and 2C. The image scanner Image J was used to compare the density of bands in each blot.
Supplementary Figure 1 from Regulation of Inflammatory Breast Cancer Cell Invasion through Akt1/PKBα Phosphorylation of RhoC GTPase
Authors: Lehman Heather L. , Van Laere Steven J. , van Golen Cynthia M. , Vermeulen Peter B. , Dirix Luc Y. , van Golen Kenneth L.
Published: April 2023

PDF file - 397K, A heatmap showing the gene-wise correlation analysis comparing the PCR data set with the Affymetrix data set for the common samples only. The PCR genes and the Affymetrix genes are depicted respectively in the rows and the columns. Each cell at the intersection between a row (PCR gene) and a column (Affymetrix gene) is color-coded according to the strength of the Spearman correlation coefficient. The legend linking the color-code to the correlation coefficient is provided in the top left corner. Along the diagonal from top left to bottom right, a distinctive pattern of yellow squares can be discerned, indicating overall strong gene-wise correlations between the PCR genes and the Affymetrix genes, validating the gene expression profiles obtained using both techniques
Supplementary Figures 1-6 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Authors: Kastrati Irida , Joosten Stacey E. P. , Semina Svetlana E. , Alejo Luis H. , Brovkovych Svitlana D. , Stender Joshua D. , Horlings Hugo M. , Kok Marleen , Alarid Elaine T. , Greene Geoffrey L. , Linn Sabine C. , Zwart Wilbert , Frasor Jonna
Published: April 2023

Supplemental Figure 1. Tamoxifen treatment induces expression of NFκBB-related genes. Supplementary Figure 2. Immune cell composition and numbers in the tumor microenvironment do not significantly change upon tamoxifen treatment. Supplementary Figure 3. NFκB pathway and EMT/stemness factors in tamoxifen-tolerant persisters in T47D cells. Supplementary Figure 4. Expression of p65 and p50 proteins in MCF-7 CRISPR/Cas9 knock out clones. Supplementary Figure 5. NFκB pathway is not directly activated by tamoxifen. Supplementary Figure 6. Sorted NFκB+ vs NFκBâ^' or unsorted tamoxifen-tolerant cells based on GFP expression were reseeded for another round of clonogenic assay and the %GFP+ population was quantified in the second round.
Supplemental Table 3 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Authors: Kastrati Irida , Joosten Stacey E. P. , Semina Svetlana E. , Alejo Luis H. , Brovkovych Svitlana D. , Stender Joshua D. , Horlings Hugo M. , Kok Marleen , Alarid Elaine T. , Greene Geoffrey L. , Linn Sabine C. , Zwart Wilbert , Frasor Jonna
Published: April 2023

Supplemental Table 3. GSEA enrichment plots
Supplemental Table 2 from The NF-κB Pathway Promotes Tamoxifen Tolerance and Disease Recurrence in Estrogen Receptor–Positive Breast Cancers
Authors: Kastrati Irida , Joosten Stacey E. P. , Semina Svetlana E. , Alejo Luis H. , Brovkovych Svitlana D. , Stender Joshua D. , Horlings Hugo M. , Kok Marleen , Alarid Elaine T. , Greene Geoffrey L. , Linn Sabine C. , Zwart Wilbert , Frasor Jonna
Published: April 2023

Supplemental Table 2. DE Genes
Supplementary Figure 3 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

PDF file - 96K, Lentivirus and siRNA mediated knockdown of UNG, UBE3B, and ICMT
Supplementary Figure 2 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

PDF file - 56K, Different methods of analysis yield similar gene enrichments
Supplementary Figure 1 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

PDF file - 285K, Screen methodology, vehicle effects to verify screening conditions, and hit selection criteria
Supplementary Methods from AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers
Authors: Balaji Kavitha , Vijayaraghavan Smruthi , Diao Lixia , Tong Pan , Fan Youhong , Carey Jason P.W. , Bui Tuyen N. , Warner Steve , Heymach John V. , Hunt Kelly K. , Wang Jing , Byers Lauren Averett , Keyomarsi Khandan
Published: April 2023

This file contains the supplementary methods
Supplementary Figures 1-7 and Tables 1 and 2 from AXL Inhibition Suppresses the DNA Damage Response and Sensitizes Cells to PARP Inhibition in Multiple Cancers
Authors: Balaji Kavitha , Vijayaraghavan Smruthi , Diao Lixia , Tong Pan , Fan Youhong , Carey Jason P.W. , Bui Tuyen N. , Warner Steve , Heymach John V. , Hunt Kelly K. , Wang Jing , Byers Lauren Averett , Keyomarsi Khandan
Published: April 2023

Supplementary Fig. 1. AXL is a direct mediator of EMT Supplementary Fig. 2. AXL inhibition causes DNA damage and reduces levels of DNA repair markers. Supplementary Fig. 3. AXL knockdown cause DNA damage and decreases gene expression of DNA repair genes Supplementary Fig. 4. AXL inhibition is synergistic with PARP inhibition. Supplementary Fig. 5. AXL inhibition in combination with PARP inhibition causes increased subG1 and G2/M populations Supplementary Fig. 6. Correlation analysis with AXL expression in patient cohorts. Supplementary Fig. 7. AXL expression corresponds to expression of DNA repair proteins and EMT markers in patient cohorts Supplementary Table 1. Doubling time upon AXL knockdown Supplementary Table 2. DNA repair proteins and EMT markers analyzed by Reverse Phase Protein Assay
Supplementary Dataset 4 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

XLS file - 615K, Fourth group of genes from the siRNA screen analyzed for gene enrichment using selection criteria of a p-value less than 0.05 and a viability ratio in the lowest 10%
Supplementary Table 1 from Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA
Authors: Xin Hong , Brown Julie A. , Gong Changning , Fan Hao , Brewer Gary , Gnarra James R.
Published: April 2023

PDF file - 25KB
Supplementary Figures 1 - 3 from Association of the von Hippel–Lindau Protein with AUF1 and Posttranscriptional Regulation of VEGFA mRNA
Authors: Xin Hong , Brown Julie A. , Gong Changning , Fan Hao , Brewer Gary , Gnarra James R.
Published: April 2023

PDF file - 296KB
Supplementary Dataset 2 from Alkylation Sensitivity Screens Reveal a Conserved Cross-species Functionome
Authors: Svilar David , Dyavaiah Madhu , Brown Ashley R. , Tang Jiang-bo , Li Jianfeng , McDonald Peter R. , Shun Tong Ying , Braganza Andrea , Wang Xiao-hong , Maniar Salony , Croix Claudette M. St , Lazo John S. , Pollack Ian F. , Begley Thomas J. , Sobol Robert W.
Published: April 2023

XLS file - 596K, Second group of genes from the siRNA screen analyzed for gene enrichment using selection criteria of a p-value less than 0.05 and a viability ratio in the lowest 2.5%
Supplementary Table 5 from Identification of Genomic Targets of Transcription Factor Aebp1 and its role in Survival of Glioma Cells
Authors: Ladha Jayashree , Sinha Swati , Bhat Vasudeva , Donakonda Sainitin , Rao Satyanarayana M.R.
Published: April 2023

XLS file - 35K, List of genes common between ChIP-chip and Microarray analysis
Supplementary Figure 1 from Regulation of mTOR Complex 2 Signaling in Neurofibromatosis 2–Deficient Target Cell Types
Authors: James Marianne F. , Stivison Elizabeth , Beauchamp Roberta , Han Sangyeul , Li Hua , Wallace Margaret R. , Gusella James F. , Stemmer-Rachamimov Anat O. , Ramesh Vijaya
Published: April 2023

PDF file - 105K, Receptor phosphorylation in merlin-deficient Schwann cells in response to serum deprivation, IGF-1 and PDGF stimulation
Supplementary Table 3 from Identification of Genomic Targets of Transcription Factor Aebp1 and its role in Survival of Glioma Cells
Authors: Ladha Jayashree , Sinha Swati , Bhat Vasudeva , Donakonda Sainitin , Rao Satyanarayana M.R.
Published: April 2023

PDF file - 113K, Motifs enriched upon ChIP-chip analysis of Aebp1
Supplementary Methods from Caveolin-1 Upregulation Contributes to c-Myc–Induced High-Grade Prostatic Intraepithelial Neoplasia and Prostate Cancer
Authors: Yang Guang , Goltsov Alexei A. , Ren Chengzhen , Kurosaka Shinji , Edamura Kohei , Logothetis Richard , DeMayo Francesco J. , Troncoso Patricia , Blando Jorge , DiGiovanni John , Thompson Timothy C.
Published: April 2023

PDF file - 47K
Supplementary Figures 1-5 from Identification of Genomic Targets of Transcription Factor Aebp1 and its role in Survival of Glioma Cells
Authors: Ladha Jayashree , Sinha Swati , Bhat Vasudeva , Donakonda Sainitin , Rao Satyanarayana M.R.
Published: April 2023

PDF file - 938K, Figure S1A: Pearson's correlation values for AEBP1 expression data. Figure S1B: Pearsons Correlation values for ChIP-Chip data. Figure S2: Sequence of Aebp1 binding site in FABP4 and FABP7 and their validation by ChIP-PCR. Figure S3 (A-X): Chromosome wiggle view of Aebp1 binding sites. Figure S4: Chromosome wise distribution of genes common between ChIP-chip and microarray. Figure S5: Position weight matrix of predicted Aebp1 binding sites
Supplementary Movie 3A from Constitutive K-RasG12D Activation of ERK2 Specifically Regulates 3D Invasion of Human Pancreatic Cancer Cells via MMP-1
Authors: Botta Gregory P. , Reginato Mauricio J. , Reichert Maximilian , Rustgi Anil K. , Lelkes Peter I.
Published: April 2023

AVI file - 4MB, Real-time imaging of E6/E7/Ras PDECs plus sh-MMP-1 in 3D show a trabelcular spreading pattern with limited invadapodial protrusions into the ECM and increased horizontal spreading over 30 m.
Supplementary Figure 4 from WNT7A Regulates Tumor Growth and Progression in Ovarian Cancer through the WNT/β-Catenin Pathway
Authors: Yoshioka Shin , King Mandy L. , Ran Sophia , Okuda Hiroshi , MacLean James A. , McAsey Mary E. , Sugino Norihiro , Brard Laurent , Watabe Kounosuke , Hayashi Kanako
Published: April 2023

PDF file - 2.5MB
Supplementary Figure Legends 1-3 from Role of Plasminogen Activator Inhibitor-1 in Urokinase's Paradoxical In Vivo Tumor Suppressing or Promoting Effects
Authors: Jing Yuqi , Kovacs Krisztina , Kurisetty Vittal , Jiang Zhijie , Tsinoremas Nick , Merchan Jaime R.
Published: April 2023

PDF file - 108K
Supplementary Table 3 from The NSD2 p.E1099K Mutation Is Enriched at Relapse and Confers Drug Resistance in a Cell Context–Dependent Manner in Pediatric Acute Lymphoblastic Leukemia
Authors: Pierro Joanna , Saliba Jason , Narang Sonali , Sethia Gunjan , Saint Fleur-Lominy Shella , Chowdhury Ashfiyah , Qualls Anita , Fay Hannah , Kilberg Harrison L. , Moriyama Takaya , Fuller Tori J. , Teachey David T. , Schmiegelow Kjeld , Yang Jun J. , Loh Mignon L. , Brown Patrick A. , Zhang Jinghui , Ma Xiaotu , Tsirigos Aristotelis , Evensen Nikki A. , Carroll William L.
Published: April 2023

RNAseq Gene Lists
Supplemental Figure 3 from ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma
Authors: Cramer Gwendolyn M. , Jones Dustin P. , El-Hamidi Hamid , Celli Jonathan P.
Published: April 2023

S3. Clonogenic survival evaluation of PANC1 +/- TGFbeta treatment response.
Figure S5 from Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Authors: Wang Yao , Stear Jeffrey H. , Swain Ashleigh , Xu Xing , Bryce Nicole S. , Carnell Michael , Alieva Irina B. , Dugina Vera B. , Cripe Timothy P. , Stehn Justine , Hardeman Edna C. , Gunning Peter W.
Published: April 2023

Tpm3.1 localizes at cell cortex during mitosis.
Supplemental Figure 2 from ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma
Authors: Cramer Gwendolyn M. , Jones Dustin P. , El-Hamidi Hamid , Celli Jonathan P.
Published: April 2023

S2. The multi-drug resistant PANC1ORGR is more mesenchymal and more sensitive to PDT than PANC1.
Figure S4 from Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Authors: Wang Yao , Stear Jeffrey H. , Swain Ashleigh , Xu Xing , Bryce Nicole S. , Carnell Michael , Alieva Irina B. , Dugina Vera B. , Cripe Timothy P. , Stehn Justine , Hardeman Edna C. , Gunning Peter W.
Published: April 2023

Aurora-A inhibitor MLN8237 (MLN) shows no or low synergy with VCR or ATM.
Supplemental Figure 1 from ECM Composition and Rheology Regulate Growth, Motility, and Response to Photodynamic Therapy in 3D Models of Pancreatic Ductal Adenocarcinoma
Authors: Cramer Gwendolyn M. , Jones Dustin P. , El-Hamidi Hamid , Celli Jonathan P.
Published: April 2023

S1. Generating PANC1 oxaliplatin resistance decreases growth rate.
Figure S3 from Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects
Authors: Wang Yao , Stear Jeffrey H. , Swain Ashleigh , Xu Xing , Bryce Nicole S. , Carnell Michael , Alieva Irina B. , Dugina Vera B. , Cripe Timothy P. , Stehn Justine , Hardeman Edna C. , Gunning Peter W.
Published: April 2023

The combinations of anti-Tpm3.1 compounds and VCR synergistically arrest HeLa cells in mitosis.
Supplementary Table 1 from Genetic and Epigenetic Inactivation of Extracellular Superoxide Dismutase Promotes an Invasive Phenotype in Human Lung Cancer by Disrupting ECM Homeostasis
Authors: Teoh-Fitzgerald Melissa L.T. , Fitzgerald Matthew P. , Jensen Taylor J. , Futscher Bernard W. , Domann Frederick E.
Published: April 2023

PDF file - 353KB
Supplemental Figure S3AB from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Authors: Alam Maroof , Ahmad Rehan , Rajabi Hasan , Kufe Donald
Published: April 2023

Supplemental Figure S3AB. A. Soluble chromatin from H1299 cells was precipitated with anti-NF-ÃŽÂºB or a control IgG. The final DNA precipitates were amplified by qPCR with pairs of primers for the NF-ÃŽÂºB binding region (NBR; +313 to +415) in intron 1 or a control region (CR; -4964 to -4823). Results are expressed as the relative fold enrichment (mean{plus minus}SD of three determinations) compared with that obtained for the IgG control (assigned a value of 1). B. For re-ChIP analysis, soluble chromatin from H1299 cells was first precipitated with anti-NF-ÃŽÂºB, then released and reimmunoprecipitated with anti-MUC1-C. The final precipitates were amplified by qPCR with pairs of primers for the NBR and CR. The results (mean{plus minus}SD of three determinations) are expressed as the relative fold enrichment compared with that obtained with the IgG control (assigned a value of 1).
Supplemental Figure S2 from MUC1-C Induces the LIN28B→LET-7→HMGA2 Axis to Regulate Self-Renewal in NSCLC
Authors: Alam Maroof , Ahmad Rehan , Rajabi Hasan , Kufe Donald
Published: April 2023

Supplemental Figure S2. MCF-7/MUC1-C cells were co-transfected with Lin28B-P1-Luc and SV-40-Renilla-Luc plasmids. At 48 h following transfection, cells were left untreated (Control), treated with DMSO as vehicle control, or treated with 5 ÃŽÂ¼M BAY11-7085 for an additional 12 h. Results are expressed as relative luciferase activity (mean{plus minus}SD of three determinations) as compared to that obtained for the control untreated cells (assigned a value of 1).
Supplementary Table 1 from PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages
Authors: Avasarala Sreedevi , Wu Pei-Ying , Khan Samia Q. , Yanlin Su , Van Scoyk Michelle , Bao Jianqiang , Di Lorenzo Alessandra , David Odile , Bedford Mark T. , Gupta Vineet , Winn Robert A. , Bikkavilli Rama Kamesh
Published: April 2023

List of PRMT6-associated proteins
Supplementary Figure 1 from PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages
Authors: Avasarala Sreedevi , Wu Pei-Ying , Khan Samia Q. , Yanlin Su , Van Scoyk Michelle , Bao Jianqiang , Di Lorenzo Alessandra , David Odile , Bedford Mark T. , Gupta Vineet , Winn Robert A. , Bikkavilli Rama Kamesh
Published: April 2023

Supplementary Figure 1. Increased expression of PRMT6 in non-small cell lung cancer.