bluuebunny/crossref_metadata_2025 huggingface dataset:
EXTENSIVELY DRUG-RESISTANT ENTERIC FEVER IN CHILDREN: SURGING THREATS OF ANTIMICROBIAL RESISTANCE AND POSSIBLE SOLUTIONS
Authors: Bibi Saima , Gilani Syed Yasir Hussain , Siddiqui Tahir Saeed , Syed Fibhaa , Arif Mohammad Ali , Haider Nighat
Published: September 2023

Background: Enteric fever is an infectious disease caused by Salmonella enterica including Salmonella Typhi and Paratyphi A and is associated with potentially serious outcomes, especially in developing countries. The study was conducted with the aim to present the clinical features, laboratory characteristics and antibiotic susceptibility in patients with culture-proven extensively drug-resistant (XDR) enteric fever and to explore drug combinations as a possible solution for the growing problem of antimicrobial resistance. Methods: This descriptive cross-sectional study was conducted in the Paediatric unit of Ayub teaching hospital. Patients admitted with culture-proven XDR enteric fever were included. Patient characteristics were documented on a predesigned proforma.  Response to antimicrobial agents including ceftriaxone and levofloxacin, azithromycin and meropenem and meropenem alone was assessed. Data was entered and analyzed using SPSS version 26. Results: A total of 53 patients participated in this study. The majority of patients 36 (67.9%) were male and above 5 years of age(n=38,71.7%). The mean age of the participants was 7.08±3.02 years. The major presenting features included fever, anorexia and pain abdomen in 53 (100%), 51 (96.2%) and 41 (77.4%) respectively. The mean duration of symptoms prior to hospitalization was 8.92±3.361 days. Of the total patients, 32(60.4%) responded to the initial therapy with ceftriaxone and levofloxacin, 11(20.8%) patients responded to meropenem alone and 10 (18.9%) patients responded to meropenem and azithromycin in combination. There was no statistically significant difference in mean duration to show response in patients receiving either of the treatments (p=0.484). Conclusion: Paediatric patients with XDR enteric fever mainly presented with fever, anorexia and pain abdomen and showed good response to therapy with the combination of ceftriaxone and levofloxacin inspite of the apparent resistance on blood culture and sensitivity
MICRO RNA 182-3-P, 519-D-5P, 378-3P AS NON-INVASIVE PREDICTORS OF PREECLAMPSIA
Authors: Ali Zaima , Zafar Uzma , Tauseef Ambreen , Zaki Saima , Khaliq Saba
Published: September 2023

Background: MicroRNAs (miRNAs) are an emerging field of interest in many diseases. Some of the miRNAs have been reported to be expressed differentially in diseased states of pregnancy. The current study was designed to measure and compare the levels of microRNA 182-3-p, 519-d-5p, and 378-3p and it was hypothesized that the microRNA 182-3-p, 519-d-5p, and 378-3p can be used as a non-invasive predictor of preeclampsia. Methods: Expression level of the miRNAs 182-3-p, 519-d-5p, and 378-3p was measured in the serum of preeclamptic and normal pregnancies by real-time PCR. Data was entered and analysed by Statistical Package for the Social Sciences 22 (SPSS). Results: Significantly high expression levels of MiRNA 182-3p, 519-d-5p and low levels of miR-378-3p were associated with preeclampsia (PE). Conclusion: The results revealed that miR-182-3p is a powerful predictor of PE with an Odds Ratio of 5.9 and can be used as a noninvasive, reliable predictor of PE to screen these patients at an early stage. Screening at early gestation with follow-up studies can emphasize the results
NON-OBSTRUCTIVE CORONARIES IN PATIENTS PRESENTING WITH THE NON ST-ELEVATION ACUTE CORONARY SYNDROME
Authors: Zada Shakir , Bhatti Khalid Iqbal , Zeb Muhammad , Pirah Romana , Musaddiq Daniyal , Memon Aziz ur Rehman
Published: September 2023

Background: Worldwide, cardiovascular diseases are the major cause of mortality and morbidity with acute coronary syndrome as the most common clinical manifestation. In a typical clinical setup, around 30% of the patients presented with “ST-segment elevation myocardial infarction (STEMI)” caused by the complete occlusion of the coronary artery and the remaining 70% with intermittent or partial occlusion of the coronary termed as non-ST elevation The aim of this study was to assess the prevalence and characteristics of non-obstructive coronary arteries among patients presenting with non ST-elevation acute coronary syndrome (NSTE-ACS) at a tertiary care cardiac center of Karachi, Pakistan. Methods: This was a descriptive cross-sectional study, conducted at a tertiary care hospital in Karachi. Study inclusion criteria were patients of either gender admitted with NSTE-ACS and age between 30-70 years. A routine coronary angiogram was performed in all the patients and the absence of ≥50% stenosis in any major epicardial vessel was taken in non-obstructive coronaries. Results: A total of 174 patients (30–70 years) were included, of which 99 (56.9%) were male and the mean age was 59.43±11.24 years. In the distribution of socioeconomic status, 54 (31.0%) were lower class, middle class 81 (46.6%) while upper-class status were 39 (22.4%). Hypertension was observed in 76 (43.7%), chronic kidney disease in 20 (11.5%), and hyperlipidemia in 55 (31.6%). Non-obstructive coronary arteries were noted in 25 (14.4%) patients. Conclusion: It is to be concluded that non-obstructive coronary arteries are fairly prevalent in patients arriving in hospital with NSTE-ACS in our population. Further research is needed to better understand the underlying pathophysiology and optimal management strategies for patients with NOCA in the setting of NSTEMI.
STUDENTS’ PERSPECTIVE OF AN IDEAL MEDICAL TEACHER - EXPECTATIONS AND REALITY
Authors: Parveen Zahida
Published: September 2023

Background: Medical teacher plays an important role in the education of medical students. Medical students always portray their teacher as an ideal. The objective of the study was to find the gap between the best qualities that an ideal medical teacher should have and the best qualities that a medical teacher actually has. Methods: This cross-sectional survey was conducted at Ayub Medical College Abbottabad from April 2021 to Dec 2021. Consented students of 4th year and Final year MBBS were the participants. Data regarding the qualities of the best medical teacher was collected on Likert scaled validated survey questionnaire. Two closed-ended questionnaires were used. Items were the same in both questionnaires. One questionnaire (Questionnaire A) was regarding expectations of students and what qualities they expected in their ideal medical teacher. The second questionnaire (questionnaire B) was about the qualities that a medical teacher actually had been exhibiting that students had experienced. Data was analyzed using SPSS version 22.0. Results: A total of 210 students participated in this study, 126 students were from 4th year and 84 were from the final year of MBBS. Ninety-one and a half percent of students thought that an ideal medical teacher should be competent in his/her subject but in reality, 48% of students reported that their teachers are competent. Ninety-four percent of students rated that an ideal medical teacher should have excellent communication skills but in reality, only 33% reported that their teachers are having good communication skills. Eighty-three (83%) students expect their teachers should be students friendly but in reality, only 22% of teachers are students caring. Eighty-nine percent of students expect that an ideal medical teacher shall demonstrate clinical skills to students but in reality, only 36% experienced demonstration from their teachers. Conclusion: There is a big gap between the expected qualities of a medical teacher and the qualities that a teacher is having in reality from students’ perspectives.  Teachers should be trained to bridge this gap,
Isolation and characterization of multi drug resistance bacterial pathogens from Song and Suswa river water in Dehradun
Authors: Pant Rakesh , Gupta Amit , Rohilla Bharat , Singh Arsh , Arya Priya , Shreya Sunidhi , Patrick Nirmal , Kumar Vijay
Published: September 2023

Antibiotics are antimicrobial drugs that kill germs and are crucial in the fight against bacterial infections. These medications are widely used in the prevention and treatment of diseases because they may either kill or stop bacteria from growing. Microbial resistance refers to bacteria's capacity to survive antibiotics' bacteriostatic or cytotoxic effects. The samples for this study are taken from Song and Suswa River, Dehradun, Uttarakhand. The main aim of this study is to isolate several species to find out if them are resistant to antibiotics. The methodologies used in this research are isolation and haracterization of bacteria, antibiotics sensitivity test. There were 17 types of antibiotics were used i.e. Azithromycin, Amikacin, Cefaclor, Cefepime, Cefoxitin, Doxycycline Hydrochloride,Erythromycin, Gentamycin, Kanamycin, Levofloxacin, Mecillinam, Mezolocilline, Penicillin G, Vancomycin, Tetracycline, Ticarcilline, Nitrofurantoin. The result was that species like Salmonella, Pseudomonas, E. coli, Klebsiella were resistant, sensitive, and intermediate against the 17 antibiotics. Antibiotic-resistant bacteria can potentially be transferred from one to another in a society. This is gradually getting frequent these days. In short, antibiotic resistance cannot be prevented or, in some cases, reversed, but we can certainly slow its progression.
Analytical method validation of cinnamaldehyde content in cinnamon (Cinnamomum burmannii) extract using high-performance liquid chromatography
Authors: Eka Puspita Oktavia , Rifai Pratita Ihsan Bachtiar , Saraswati Andini
Published: September 2023

The use of herbal medicinal plants has been found widely in the community as traditional medicine. One example is the Cinnamon plant (Cinnamomum burmannii) which contains cinnamaldehyde as the main compound. Cinnamaldehyde is known to have a major role in lowering blood sugar levels. Determination of the content of bioactive compounds in extracts is beneficial in determining the safety, quality, and efficacy of the plants used. So it is necessary to do a quantitative analysis test on the cinnamaldehyde compound in cinnamon plants by determining its levels using the HPLC method. It is necessary to validate the method analysis based on parameters including selectivity, linearity, accuracy, precision, detection limit, and quantitation limit. The mobile phases in this method were acetonitrile mobile and 0.04�etic acid solution (60:40), The stationary phase was octadecylsilane (C-18), The flow rate was adjusted at 1.0 mL/min with column temperature adjusted at 29°C, injection volume 20 μl, and using a Photodiode array detector at a wavelength of 280 nm. The results showed that the resolution value obtained was 3.401; the correlation coefficient value obtained is 0.9941; The percent recovery obtained between 98.74% - 101.95%; percent RSD obtained between 0.92% - 2.68%; and the LOD and LOQ values were 0.069 ppm and 0.23 ppm. The HPLC method met the validation requirement and can conclude to be valid.
Design synthesis in-silico study and biological evaluation of quinoline derivatives as potential antibacterial agents
Authors: Kumar Gurjar Vinod , Raj Mukeshbhai Dodiya , Raju Kushwaha , Devanshi Parekh Subhash
Published: September 2023

The purpose of this article is to synthesize some novel quinoline-3-Carboxylic acid derivatives, analyze them, and assess their antibacterial potential. With the help of elemental analysis, IR, NMR, and mass spectral data, the synthesized derivatives were identified. Derivatives' antibacterial activity was determined using the cup and plate diffusion method. At doses of 50 μg/ml and 100 μg/ml, the substance demonstrated substantial antibacterial potential against the tested strains. To predict the pharmacokinetic properties (ADME) of these derivatives, in-silico investigations were also carried out. For the current study, the in silico Swiss ADME-assisted results were shown to be suitable for the derivation and synthesis of efficient antibacterial drugs.
Comparative analysis of antioxidant, antimicrobial, and tyrosinase inhibitory activities of Centella asiatica (l.) Urb and Eichhornia crassipes (mart.) Solms
Authors: Powthong Pannapa , Suntornthiticharoen Pattra
Published: September 2023

In the present study, we examined the potential biological activities of two marginal weeds, Centella asiatica (L.) Urb and Eichhornia crassipes (Mart.) solms, using various solvents (water, methanol, and ethyl acetate). The ethyl acetate and ethanol crude extracts of Centella asiatica exhibited notable antioxidant activity, as indicated by their DPPH radical scavenging ability, with values of 349.33±3.92 and 348.48±2.96 µg Vitamin C equivalents/0.01 g dry matter, respectively. These extracts effectively inhibited free radicals from DPPH at half maximal effective concentrations (EC50) of 160.46±1.62 and 1,330±25.25 µg/mL, respectively. Furthermore, the ethyl acetate crude extract of E. crassipes (Mart.) solms, demonstrated the highest content of total phenolic compounds, with 185.88 ± 2.31µg GAE/0.01 g dry matter, as determined by the Folin-Ciocalteu colorimetric assay. Additionally, the ethyl acetate extract of E. crassipes (Mart.) solms, displayed potent tyrosinase inhibitory activity, with an IC50 value of 67.93±0.82 µg/mL. Regarding antimicrobial activity, both the ethyl acetate and ethanol crude extracts of C. asiatica (L.) Urb exhibited potential against three of the seven tested bacterial strains, as determined by the agar well diffusion method. These findings highlight the significant biological activities of C. asiatica (L.) Urb and E. crassipes (Mart.) solms, extracts, suggesting their potential for various scientific applications. Further studies are necessary to explore their diverse range of potential applications.
The impact of walking as a physical activity on vitamin D levels and sleep quality
Authors: G Rambu Kareri Dyah , R Tallo Manafe Derri , M Br Damanik Efrisca
Published: September 2023

Vitamin D is a fat-soluble compound with antioxidant properties that are important for maintaining the body's mineral balance. Vitamin D can be obtained from exogenous sources (food) or endogenously synthesised by the skin through exposure to the sun's ultraviolet rays. Although it is a vitamin, it is also considered a hormone because it is activated by chemical reactions in the body. The aim of this study was to analyse the effect of walking on vitamin D levels and sleep quality. The research used a quasi-experimental method with a randomised pre- and post-test-controlled group design. In this study, two groups were randomised, the intervention group and the control group. Both groups were pre-tested and then post-tested to find out the difference in average vitamin D levels and sleep quality. Gender, age, BMI, systolic and diastolic blood pressure were not found to be confounding variables. There were no significant changes in the pre- and post-sleep quality scores of the control group. In addition, there was no significant difference in pre-sleep quality and a significant difference in post-sleep quality. However, there is a significant difference in changes in vitamin D levels between the control and intervention groups. There is a significant effect of walking on vitamin D levels and sleep quality.
The effect of robust coffee towards the malondialdehyde level in healthy adults
Authors: Lidesna Shinta Amat Anita , Pieter Louis Wungouw Herman , Pakan Prisca
Published: September 2023

Coffee contains more than a thousand molecules, including phenolic compounds, vitamins, minerals and alkaloids. Caffeine, cafestol, kahweol and chlorogenic acid are related to lipid metabolism and can affect serum lipid profiles. Clinical studies have reported the effects of caffeine on cardiac arrhythmias, liver function, serum cholesterol and blood pressure. Malondialdehyde (MDA) in the human body is a by-product of free radicals (oxidative stress), which can indicate whether oxidative stress is detrimental. This study aims to analyse the effect of strong coffee on MDA levels in healthy adults. This study used a quasi-experimental design with a nonequivalent control group. This design was divided into two groups: the treatment group and the control group. The treatment group was given the treatment of drinking coffee and not eating foods that can raise cholesterol. In the control group, they did not drink coffee or eat foods that could cause increased malondialdehyde levels. The results showed that coffee increased MDA levels in 91% of the samples. Thus, strong coffee can increase malondialdehyde (MDA) levels in healthy adults.
Hypertension treatment in rural Indonesia during the COVID-19 pandemic: An analysis
Authors: Riwu Magdarita , Lidia Kartini , Pakan Prisca
Published: September 2023

People with chronic diseases are at higher risk of a pandemic threat because COVID-19 can affect their clinical outcomes, including mental illness and cardiovascular disease. COVID-19 has reduced access to healthcare facilities and physicians for patients with chronic diseases who require regular visits, follow-ups, testing and prescription refills. The aim of this study is to analyse the effectiveness of hypertension therapy based on the patient's blood pressure level at each visit. This is a descriptive-analytical study that uses a cross-sectional approach and retrospective data. Data collection started in April and ended in October 2021. Data were collected from the medical records of the Oesapa Health Centre in Kupang City to conduct the research. 165 respondents participated in the study. The results of the study of patients with hypertension in the area of research data showed non-compliance in carrying out health control or treatment, namely 229 respondents (83.27%), then two visits by 28 respondents (10.18%), three visits by 13 respondents (4.73%), four visits with 3 respondents (1.10%), five and ten visits for health check-ups, each with only one respondent (0.36%). The results of this study suggest that the pandemic state of COVID-19 has a significant impact on patients' compliance with their health check-ups and on their treatment outcomes.
A Password and Least Significant Bit Substitution Based Steganography Technique for Image Hiding
Authors: Mandal Unmesh , Nag Diotima , Das Goutam , Saha Rimpi
Published: September 2023

The proposed work introduces an image steganography technique using text-based password that acts as the symmetric key of encryption and decryption. It contains two components, an encoder, and a decoder. An encoder takes a secret image that needs to be hidden inside another cover image. The Combined image is encrypted with an eight characters’ password. The starting position of the cover image from where the secret image starts to hide depends on the password. Then the (Least Significant Bit) LSB Substitution technique is used to hide the entire secret image inside the cover image. The decoder takes the encrypted image and the password to retrieve the secret image back. The proposed work produces an encrypted image by keeping 99% information of the cover image and 100% information of the secret image, thus it provides lossless retrieval of the secret image. The proposed work includes dynamicity of position in steganography that ensures more security of image data over the network than the existing state of art methods.
Implikasi Legal Market Power Assessment dalam Big Data pada Era Ekonomi Digital
Authors: Stefanus
Published: September 2023

Perkembangan informasi dan teknologi dalam dunia hukum telah terjadi semenjak era digitalisasi ikut berkembang. Di Indonesia sendiri perkembangan ini mulai dengan adanya pengaturan mengenai telekomunikasi hingga yang terbaru mengenai perlindungan data pribadi. Sejauh ini pengaturan-pengaturan di Indonesia sendiri terlihat masih berdiri sendiri tanpa adanya paying hukum meskipun beberapa ahli hukum menyebutkan Undang-Undang Informasi dan Transaksi Elektronik sebagai semi payung hukum dari pengaturan digitalisasi di Indonesia. Masuknya elemen digitalisasi berupa Big Data sebagaimana halnya teknologi tak jarang menimbulkan sebuah distrupsi baru bagi penegakkan hukum persaingan usaha di Indonesia yang tak jarang kita ketahui sulit untuk melakukan pembuktian secara hukum, hal ini dapat terlihat dari adanya ilmu ekonomi sebagai salah satu ilmu yang membantu dalam penerapan hukum persaingan usaha, dengan masuknya Big Data ini muncul lagi ilmu baru yang nampaknya perlu menjadi perhatian bagi Komisi Pengawas Persaingan Usaha dalam melaksanakan aturan teknis terkait Undang-Undang tentang Larangan Praktek Monopoli dan Persaingan Usaha Tidak Sehat di Indonesia.
Interaksi Persaingan Usaha dan Perlindungan Data: Menelaah Bundeskartellamt v. Facebook
Authors: Safitri Siti Shalima
Published: September 2023

Big Data membawa tantangan baru dalam hal hukum persaingan usaha dan perlindungan data. Persinggungan pengaturan data dalam hukum persaingan usaha disebabkan sebagian besar produk digital dibayar oleh pengguna dan konsumen secara online dengan memberikan data pribadi mereka. Penulis akan membahas perihal apakah pelanggaran data dapat dianggap sebagai pelanggaran hukum persaingan usaha, mengingat kasus Facebook Jerman di mana Bundeskartellamt menyelidiki apakah dugaan pelanggaran ketentuan perlindungan data dapat diartikan bahwa Facebook menyalahgunakan posisi dominannya di pasar digital. Penelitian menggunakan metode hukum normatif dengan studi pustaka. Hasil penelitian menunjukkan penyalahgunaan (abuse) pasar digital tidak dapat ditarik dari sebatas dominasi atau persyaratan kontrak yang tidak adil, melainkan perlu adanya kombinasi dari kekuatan pasar serta tidak adanya pilihan lain atas persyaratan kontrak. Jika pengguna Facebook diberikan lebih banyak pilihan sehubungan dengan bagaimana data mereka dikumpulkan, maka mereka akan dianggap memberikan persetujuan secara sukarela (voluntary consent) di bawah hukum perlindungan data. Penelitian ini dapat dijadikan sebagai pedoman bagi pembentuk undang-undang dan otoritas berwenang di bidang persaingan usaha Indonesia untuk menyesuaikan peraturan persaingan usaha khususnya di era digitalisasi.
Factors influencing the change-supportive behavior: learning agility, perception of reasons and benefits for change
Authors: Franco Kettyplyn Kamila Sanches , Neiva Elaine Rabelo
Published: September 2023

This study aimed at describing the influence of individual factors such as Learning Agility and the perception of reasons and benefits for change on change-supportive behavior.  The study has also tested the effect of leadership position on learning agility and on change- supportive behaviors. The model was tested by a cross-section quantitative study in two corporations, with a sample of 324 employees. It used four instruments (learning agility scale, scales of reasons and benefits for change, and scale of behavioral responses to change) with evidence of validity, in addition to standard multiple regression analyses and structural equations to test the model. Results point out that reasons and benefits perceived for change and learning agility predict change-supportive behaviors, and also that leadership position predicts change-supportive behaviors.
Análise da voz como parâmetro de avaliação respiratória na pós COVID-19
Authors: De Andrade Naiara Lilian Favatto , Favatto Naline Cristina , Matsuo Adriano Ruy , Amorim Geová Oliveira , Esteves Roberto Zonato
Published: September 2023

A pesquisa teve como objetivo desenvolver um protocolo de avaliação vocal e respiratória de pessoas em recuperação da COVID-19. Como estudo piloto de aplicação, foi conduzida uma pesquisa exploratória com abordagem quantitativa, sendo os participantes em recuperação da COVID-19, selecionados mediante os dados epidemiológicos da Secretaria Municipal de Saúde de Santa Fé. O protocolo desenvolvido e aplicado foi composto por uma anamnese, testes de avaliação vocal e respiratória, e teste funcional. A anamnese contemplava dados antropométricos do participante, as queixas dos sintomas atuais e as queixas no diagnóstico da COVID-19, além do relato de fadiga. Na sequência, para a avaliação vocal, a análise acústica da voz foi realizada por meio do software Praat, utilizando os parâmetros: Tempo máximo fonatório (TMF), Jitter, Shimmer, Frequência fundamental e Intensidade. Por fim, para a avaliação funcional, foi performado o teste de caminhada de seis minutos (TC6). Além desses parâmetros base, foram avaliados dados vitais como: pressão arterial, saturação de oxigênio, frequência cardíaca e respiratória, e a mensuração da dispneia ao esforço por meio da Escala de Borg. A análise estatística dos dados coletados realizou-se de forma descritiva e inferencial por meio do software SPSS. Foi aplicado o teste Qui-quadrado de independência, e o nível de significância estatística adotada de p ≤0,05. As análises preliminares não apresentaram correlação estatisticamente significante entre as variáveis, porém podemos observar uma tendência de relação entre as medidas de tempo máximo fonatório, distância percorrida no TC6 e o relato de fadiga.
O trabalho docente no contexto da reprodução ampliada do capital
Authors: Feitosa Maria da Penha , Cruz Rosana Evangelista da
Published: September 2023

O objetivo do presente texto é analisar o trabalho docente no contexto da reprodução ampliada do capital. O que importa problematizar é como a racionalidade que antes envolvia apenas o trabalho em setores considerados diretamente produtivos tem paulatinamente atingido o setor de serviços, mais especificamente o trabalho docente. A metodologia utilizada foi o estudo bibliográfico, de natureza exploratória, orientado pela concepção materialista e dialética da história, no qual são discutidas categorias como trabalho, trabalho docente, subsunção, trabalho produtivo e trabalho "improdutivo", reprodução ampliada de capital, em diálogo com autores como Marx e Engels, Duarte, Saviani, Mészáros, Ferraz, Oliveira e outros. A leitura da bibliografia disponível para compreensão da temática foi feita considerando a linha teórica de interpretação da realidade dos autores e suas produções desde clássicos como Marx e Engels a autores contemporâneos.
Notificação de óbito para doação de córneas: desenvolvimento e avaliação de sistema digital
Authors: Cabianchi Ellen Catarine , De Freitas Rosane Almeida , Gavioli Aroldo , Dianin Antônio Henrique , De Oliveira Sergio Ricardo Lopes , Jaques André Estevam , Dos Santos Marcelo José , Agnolo Cátia Millene Dell
Published: September 2023

Desenvolver e avaliara usabilidade de um sistema digital de notificação de óbitos por parada cardiorrespiratória para fins de doação de córneas para transplante. Estudo metodológico de produção tecnológica, para desenvolvimento de sistema digital de notificação de óbitos, a partir de uma ficha de notificação elaborada e padronizada pela Central Estadual de Transplantes, em uso por todos os hospitais no estado do Paraná que possuem Comissão Intra-Hospitalar de Doação de Órgãos e Tecidos para Transplantes, seguido de avaliação da usabilidade do sistema por profissionais que atuam na assistência, em um hospital escola no município do noroeste do Paraná. Os dados foram coletados por amostra de conveniência através de questionário tipo Likert. Foi desenvolvido o sistema com base na ficha de notificação de óbito, onde a resposta do sistema orienta o enfermeiro notificante a qual conduta tomar. Após o desenvolvimento, avaliada a usabilidade por 101 enfermeiros com análise da confiabilidade e consistência interna do instrumento de medição por meio do cálculo do coeficiente Alfa de Cronbach, com valor final de 0,92 de confiabilidade, configurando uma confiabilidade alta. De acordo com os resultados do teste estatístico sua usabilidade foi considerada adequada para o público.
Palhaçoterapia em pacientes adultos: um estudo comparativo
Authors: Ribeiro Mateus Gonçalves , De Souza Ana Carolina Dominicci , Castiglioni Lilian , Batigalia Fernando , Dos Santos Junior Randolfo , Rondina João Marcelo , Bianchin Maysa Alahmar
Published: September 2023

O cenário de estudos empíricos quanto ao efeito da palhaçoterapia em pacientes adultos é escasso. Comparar a ansiedade e depressão e avaliar a eventual melhora no estado de humor entre pacientes adultos internados expostos e não expostos à palhaçoterapia. Análise descritiva e exploratória de 102 pacientes do Hospital de Base de São José do Rio Preto utilizando a Escala Hospitalar de Ansiedade e Depressão (HADS) e uma entrevista semi-estruturada. Dentre os participantes, 52 encontravam-se na enfermaria de transplante - a qual recebe semanalmente a participação do projeto “Eis-me aqui” de palhaçoterapia - e 50 na enfermaria de oncologia, a qual não participa do projeto. A HADS mediu o nível de ansiedade e depressão antes e após a exposição à palhaçoterapia e a entrevista semi-estruturada avaliou a satisfação dos pacientes com a intervenção e os classificou sociodemograficamente. Observou-se que ambos os grupos tinham níveis semelhantes de ansiedade e depressão (p=0,9845 e 0,9026 respectivamente) e que, no grupo de transplante, houve redução da ansiedade após a intervenção terapêutica (p=0,0020). A depressão pós-intervenção no mesmo grupo não obteve diferença estatística, provavelmente por ser um estudo transversal (p=0,2999). Ademais, com a entrevista semi-estruturada, pôde-se detectar a demanda por socialização e por melhora de humor. Os participantes, além de apresentarem melhora no humor e diminuição significativa da ansiedade, avaliaram a atividade como positiva; apesar de não ser observada também qualquer mudança nos níveis de depressão. Ratifica-se, pois, o potencial benéfico da palhaçoterapia para além do ambiente pediátrico.
Manejo de Spodoptera frugiperda com diferentes números de pulverizações de inseticidas biológicos e sintético
Authors: Loureiro Elisângela de Souza , Do Amaral Francieli Aparecida , Dias Pamella Mingotti , Pessoa Luis Gustavo Amorim , De Gregori Gabriela Silva , Machado Amanda Camargo , Rodrigues Andressa Silva , Cândido Gabriel Silva
Published: September 2023

A lagarta Spodoptera frugiperda (J. E. Smith, 1797) (Lepidoptera: Noctuidae), afeta a produtividade da cultura do milho, sendo necessárias alternativas para seu controle. Objetivou-se neste trabalho avaliar seu manejo com diferentes entomopatógenos e inseticida, e números de aplicações, em campo. O delineamento experimental foi em blocos ao acaso (DBC), avaliando-se um ensaio com uma pulverização com diferentes bioinseticidas e inseticida, e um com duas e três pulverizações utilizando diferentes bioinseticidas. Os tratamentos foram: testemunha (água destilada + espalhante adesivo Tween 80®); inseticida Exalt® (espinosinas: espinosade); fungo Metarhizium rileyi (Mr); bioinseticida a Xentari® (bactéria B. thuringiensis subsp. aizawai) (Bt); bioinseticida Diplomata® (vírus Helicoverpa armigera Nucleopolyhedrovirus (HearNPV). Com uma pulverização, 7 DAP o inseticida Exalt® proporcionou melhor controle. Após a segunda pulverização, 14 DAP, o tratamento Metarhizium rileyi (2 pv) proporcionou controle mais efetivo, após a terceira pulverização não houve diferença na infestação de insetos entre os tratamentos.
Explorando as inovações tecnológicas para potencializar a integração entre estudantes: o estudo de caso do curso de especialização em Gestão de Saúde
Authors: De Medeiros Caroline , De Pires Denise Elvira Pires , Miranda Junior Jaime , Do Prado Rosane Aparecida , Ribeiro Gerusa
Published: September 2023

O Ensino a Distância (EAD) é uma modalidade educacional em que a mediação didático-pedagógica ocorre por meio de tecnologias de informação e comunicação, possibilitando que estudantes e professores desenvolvam atividades educativas em locais e horários diversos. No entanto, um dos desafios enfrentados nesse processo é a integração social entre os estudantes, especialmente nas disciplinas iniciais do curso, pois os pólos ou cidades que recebem as aulas atendem a uma região ampla, com estudantes de características diversas. Para promover uma integração mais efetiva entre os estudantes do curso de especialização em gestão em saúde do IFSC, foi adotado o YouTube como ferramenta principal para a atividade obrigatória da primeira unidade curricular (Introdução à informática e AVA), utilizando a metodologia ativa. Os estudantes foram organizados em grupos e desafiados a criar vídeos apresentando temas relacionados ao curso. Para avaliar o grau de integração, um questionário foi aplicado a todos os participantes. Os resultados da dinâmica com o YouTube foram positivos, com mais de 70% dos estudantes que responderam ao questionário aprovando a utilização dessa ferramenta. Isso demonstra que a metodologia ativa, por meio do uso do YouTube, foi eficaz na promoção da integração social e no engajamento dos alunos, proporcionando uma experiência de aprendizagem enriquecedora no contexto do Ensino a Distância.
Hanseníase: limites e possibilidades do ensino na graduação de enfermagem
Authors: Chaves Ana Elisa Pereira , De Medeiros Soraya Maria , Clementino Francisco de Sales , De Oliveira Jonas Sami Albuquerque , Silva Sara da Rocha , Silva Flávia Gomes , Valença Cecília Nogueira , De Sousa Yanna Gomes
Published: September 2023

A Hanseníase é caracterizada como uma doença infectocontagiosa, que quando diagnosticada e/ou tratada tardiamente ocasiona lesões irreversíveis. Nesse sentido, o objetivo da pesquisa foi analisar as abordagens do ensino da Atenção à Hanseníase nos Cursos de Graduação em Enfermagem. Trata-se de um estudo exploratório-descritivo realizado com vinte e um docentes de seis cursos de graduação em enfermagem através de uma entrevista semiestruturada que ocorreu entre os meses de setembro a outubro de 2016. A análise do material empírico foi realizada com auxílio do software Interface de R pour les Analyses Multidimensionnelles de Textes et de Questionnaires, por meio da análise de Classificação Hierárquica Descendente e posteriormente foram sistematizados em classes. A análise dos dados revelou que os docentes vivenciam uma prática pedagógica de ensino limitada pela carga horária de aula reduzida nos componentes curriculares que abordam a hanseníase e falta de planejamento das atividades de trabalho das equipes de atenção básica. A utilização de aulas teóricas e práticas na rede de atenção à saúde é tida como possibilidade de formação de enfermeiros resolutivos no atual cenário de saúde. Portanto, o trabalho docente evidenciou fragilidades no tocante a qualidade do ensino prestado, o qual é organizado em currículos tradicionais que não respondem aos problemas de saúde pública.
Effect of Capital Structure, Company Size, Profitability, and Company Growth on Company Value
Authors: Rezeki Erlina Sri , Budi Santoso Selamet Eko , Wahyuni Sri , Dirgantari Novi
Published: September 2023

This study aims to determine the effect of capital structure, company size, profitability, and company growth on firm value. This research and the data used are secondary data in the form of the company's annual report. In this study, the population used is energy sector companies listed on the Indonesia Stock Exchange for the 2017-2021 period. The sample in this study was selected using a purposive sampling method and obtained 22 companies as a sample and the amount of data observed or researched was 81 data. The data analysis method in this study is multiple regression analysis using IBM SPSS Statistics version 26. The results of this study indicate that capital structure does not affect firm value, firm size has a positive effect on firm value, profitability has a positive effect on firm value, and company growth does not affect on firm value.
Digitalization of Management Information Systems at Intuition Bookstore Makassar City
Authors: Asriyani Ismail
Published: September 2023

Along with the development of the business world, computers have an important role in facilitating the completion of a job and helping to develop a maximum service system to support company performance, one of which is by building an information system. The process of managing book data can run smoothly and produce precise and accurate information, a digitization system is needed that can process the book management system as a whole in order to minimize errors that often arise. The purpose of this research is to design a desktop-based INTUISI bookstore management information system. The design method uses the UML method with the data analysis process using the PIECES method. The result is that the management digitization process at the INTUISI bookstore becomes easier and more efficient in reporting the management that occurs, this can be seen from the results of the User Acceptance Test (UAT).
Flood Disaster Response Cadre Training in Keliling Benteng Ulu Village, Martapura Barat Sub-District
Authors: Fujiati  , Nelly Al Audhah  , Dwi Setyohadi  , Endah Labati Silapurna  , Abrari Fauzi  , Brian Pramana Santoso  , Marcellino Febryan  , William Luth  , Sayid Akhmad Zein  , Irawanto
Published: September 2023

A flood is an event where land is submerged due to an increase in water volume. The flood that occurred in RT.05 Keliling Benteng Ulu Village was the worst compared to other RTs, because they live on the edge of the Martapura river and swamp environment. This service activity educates cadres to fulfill basic needs (clean water and sanitation needs, food clothing, temporary shelter, and health services) and provides leaflets/booklets on the stages of flood disaster management in fulfilling the basic needs of the community. The results of the pre and post test evaluation, cadres' knowledge has increased ≥ 80% regarding flood disaster response and about fulfilling the basic needs of flood disaster management independently (making freshwater fish jerky and instant ginger).
Training and Implementation of Catfish Feed Technology in the Sedana Sari Fish Farmers Group in Selat Village, Abiansemal, Badung, Bali
Authors: Sang Ayu Made Putri Suryani  , Anak Agung Sagung Putri Risa Andriani  , I Gusti Ayu Dewi Seri Rejeki  , Gede Agus Surya Pratama
Published: September 2023

Catfish is one type of freshwater cultured fish that has the potential to be developed. Cultivation with advanced technology in intensive systems requires more feed intake good quality pellet feed is needed but at an affordable price. The problem of the high cost of cultivating catfish is a challenge that must be resolved. Activities were carried out in 3 stages including counseling and workshops, planning, the practice of making fish feed pellets, and monitoring and evaluating. The results in the activities of catfish farmers conveyed problems and exchanged experiences of the problems experienced. Furthermore, to find out the sustainability of the program, the team conducted monitoring and evaluation and the activities continued even though there were few problems.
Modification and Characterization of Polyamide Nanocomposites with Organobentonite Cetyltrimethylammonium Bromide
Authors: Aritonang Barita , Ritonga Ahmad Hafizullah , Harefa Karnirius
Published: September 2023

Modification of bentonite with Cetyl Trimethyl Ammonium Bromide (CTAB) has been successfully carried out, resulting in the application of organobentonite as a filler. The purpose of this study was to determine the characteristics of the polyamide nanocomposite material before and after the addition of organobentonite filler. Commercial bentonite after being modified with CTAB is organophilic with a particle size of 9.55 nm. The results of the Fourier Transform Infra Red spectrum analysis show that there is a wide and sharp absorption band at wave number 3749.6 cm-1 which indicates the presence of Al-OH groups. The results of Scanning Electron Microscopy analysis of the surface morphology of the polyamide/organobentonite nanocomposite obtained a homogeneous and compatible mixture. The conclusion from the CTAB research results can unite polyamide and bentonite which have different polarities
To Investigate the Correlation Between the Socioeconomic Status and Cardiometabolic Associated Risk Indicator Among Middle Aged Adults in Selected Sub-Counties in Kisumu County in Nyanza Region in Kenya
Authors: Ambrose Barasa M , Doreen Cherop , Neel G.R , Aluoch Mercyline Natasha , Katabazi Aziz , Emmanuel Eilu
Published: September 2023

The prevalence of Cardio- metabolic associated risk indicators are known to vary significantly across the world (Huh et al., 2019). Study design. This was a cross-sectional quantitative study on correlation between socioeconomic and cardio metabolic associated risk indicators among Residents in selected sub counties in Kisumu county Nyanza region in Kenya. It involved the determination of five indicators of cardio metabolic disorders, which included; general obesity (BMI), central obesity (waist: hip ratio), blood pressure (SBP and DBP), dyslipidemia (Lipid profile) among the residents. Results. Our study showed a strong association between BMI, WC and hypertension in the study population. These findings are in agreement with other studies that also reported an association between hypertension and prehypertension, BMI and WC as well as diabetes (hypertension 19.4%, obesity 44%, hyperglycemia 21.8% and dyslipidemia 14.9%)
Development of Game-based Learning Media for Early Childhood Animal Recognition
Authors: Lestariningsih Tri , Kusbandono Hendrik , Paksi Angger Binuko , Afandi Yosi , Sumafta Ikhwan Baidlowi
Published: September 2023

Cognitive learning activities through the introduction of animals in Early Childhood (AUD) have a very important role in developing all children's potential. One of them is the potential intelligence of children. AUD is a pretty good stage for training the brain of a child, where they will be more interested and active when they see a game or such that contains a lot of animation and sound. With the existence of game-based animal recognition learning media, it will be an interesting thing for early childhood, namely kindergarten, as well as teachers when interacting and conducive to learning. This learning medium contains several learning points and games that train children's cognitive abilities. There is a learning menu to recognize the name of the animal and its voice, then the game composes the word and guesses the illustration image of the animal, as well as the support of singing videos about animals given by the teacher to children. Game-based learning media is built using constructivism, using Luther Sutopo's method. The result of this research is an animal recognition learning medium for early childhood.
Bread Yeast Fermentation Method Production of Papaya (Carica Papaya L.) Fruit Bioethanol
Authors: Muliarta I Nengah , Setianingsih Ni Luh Putu Putri , Sudiarta I Wayan , Prawerti Desak Ayu Diah , Somariana I Kadek , Putra I Ketut Suwarmadi
Published: September 2023

Making bioethanol from papaya fruit is done through a fermentation process. Yield is influenced by the duration of fermentation and the mass variation of the bread yeast Saccharomyces cerevisiae. The pH treatment and initial sugar content of the substrate were also tested before the addition of glucose. This study aims to examine the effect of yeast concentration and fermentation time on the amount of bioethanol produced from papaya fruit in the manufacture of bioethanol. The maximum concentration of bioethanol produced by a concentration of 2% S. cerevisiae is 5.44% due to the addition of yeast, according to the number of nutrients in the sample. In order of concentration from high to low, it is 2% > 4% > 3% > 5% > 1%. While the maximum pH value of 4.9 with a concentration of 2% was obtained in ethanol production by Saccharomyces cerevisiae.
Green Marketing, Lifestyle, and the Purchase Intention of Bottled Water among Generation Z
Authors: Abhirama Abid , Wardani Nuruni Ika Khusuma , Amriel Egan Evanzha Yudha
Published: September 2023

This research aims to analyze the influence of green marketing and lifestyle on the purchase intention of Ades mineral water in Surabaya, particularly among Generation Z and millennials. The population in this study consists of consumers of packaged drinking water who are familiar with the Ades brand and are aged between 17 to 43 years. The sampling technique used to determine the sample is non-probability sampling with the purposive sampling method, involving 112 respondents. The analysis method employed is Smart PLS software with the Structural Equation Modeling (SEM) technique. The results of this study indicate that: (1) Green marketing has a positive influence on purchase intention, with a value of 0.590; (2) Lifestyle has a positive influence of 0.131 on purchase intention.
Comparison of Estimation of Glomerulus Filtration with MDRD and CKD-EPI Formula in Diabetes Mellitus Patients Type 2 in Bhayangkara Hospital Palembang
Authors: Mutholib Abdul , Asrori  , Refai  , Wibowo Wahyu Dwi Ari
Published: September 2023

Patients with uncontrolled type 2 diabetes mellitus (DM) can be at risk of complications with the kidneys. The decrease in the condition of the kidneys impacts the ability of the glomerulus to filter. This study aims to compare the estimated glomerular filtration rate (eGFR) based on Creatinine Levels with MDRD and CKD-EPI Formulas. The research was conducted with a cross-sectional approach. The study was carried out from March to April 2021. The sample size of this study was 97 data points on Type 2 DM. The result shows the average eGFR values with the MDRD and CKD-EPI formulas in people with Type 2 DM were 97.85 ml/min/1.73 m2 and 85.67 ml/min/1.73 m2. From the Mann-Whitney test, the results obtained were p> α (0.05), p-value = 0.3498. There were differences in the eGFR values calculated by the MDRD and CKD-EPI formulas.
The Effect of Training and Its Impact on the Performance of Agricultural Investors in the Nias District
Authors: Dachi Adventina , Lumbanraja Prihatin , Daulay Pardamean
Published: September 2023

This research investigates the influence of training initiatives on the performance of agricultural investors in the Nias District. With the agricultural sector playing a crucial role in the district's economy, enhancing investor performance becomes essential for sustainable growth. Initial findings suggest a positive correlation between training participation and investor performance. Training programs are shown to equip agricultural investors with valuable skills, knowledge, and techniques, enabling them to make informed decisions, optimize resource utilization, and implement best practices. Additionally, the study identifies various factors influencing the effectiveness of training, including program content, delivery methods, and ongoing support. In conclusion, this study emphasizes the significance of training programs in enhancing the performance of agricultural investors within the Nias District.
The Influence of Transformational Leadership on the Performance of Food Security, Agriculture, and Fisheries Service Employees in Nias Regency
Authors: Halawa Oliziduhu , Sadalia Isfenti , Meliala Janita S.
Published: September 2023

Leadership is very influential on activity and continuity in organizations, so leadership is one key to success in organizations. Leaders who aren't competent in anticipating and deliver response fast to change will cause organization slow for adapt change so that employee No will Once increase with optimal. The type of research is study quantitative. Study quantitative is data research in form the numbers obtained from respondent. Population in study This is whole Food Security, Agriculture and Fisheries Service Employees Regency Nias as many as 65 people. Questionnaire study given direct to respondent with choose one alternative answers that have available. Statement customized with need study with using a Likert Scale. In research this, method analysis used is method descriptive quantitative. This show that variable leadership transformational influential positive by 38.6%, p This can determined based on R Square value of 0.386 and significant to performance staff at the Department of Food Security , Agriculture and Fisheries Regency Nias.