bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 3 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Authors: Fox Emily M. , Miller Todd W. , Balko Justin M. , Kuba Maria G. , Sánchez Violeta , Smith R. Adam , Liu Shuying , González-Angulo Ana María , Mills Gordon B. , Ye Fei , Shyr Yu , Manning H. Charles , Buck Elizabeth , Arteaga Carlos L.
Published: March 2023

PDF file - 6.6MB
Supplementary Figure 5 from Stromal Estrogen Receptor-α Promotes Tumor Growth by Normalizing an Increased Angiogenesis
Authors: Péqueux Christel , Raymond-Letron Isabelle , Blacher Silvia , Boudou Frédéric , Adlanmerini Marine , Fouque Marie-José , Rochaix Philippe , Noël Agnès , Foidart Jean-Michel , Krust Andrée , Chambon Pierre , Brouchet Laurent , Arnal Jean-François , Lenfant Françoise
Published: March 2023

PDF file - 517K, Vascular cell proliferation status
Supplementary Figure 2 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Authors: Fox Emily M. , Miller Todd W. , Balko Justin M. , Kuba Maria G. , Sánchez Violeta , Smith R. Adam , Liu Shuying , González-Angulo Ana María , Mills Gordon B. , Ye Fei , Shyr Yu , Manning H. Charles , Buck Elizabeth , Arteaga Carlos L.
Published: March 2023

PDF file - 190K
Supplementary Figure 10 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Authors: Fox Emily M. , Miller Todd W. , Balko Justin M. , Kuba Maria G. , Sánchez Violeta , Smith R. Adam , Liu Shuying , González-Angulo Ana María , Mills Gordon B. , Ye Fei , Shyr Yu , Manning H. Charles , Buck Elizabeth , Arteaga Carlos L.
Published: March 2023

PDF file - 4.2MB
Supplementary Figure 1 from A Kinome-Wide Screen Identifies the Insulin/IGF-I Receptor Pathway as a Mechanism of Escape from Hormone Dependence in Breast Cancer
Authors: Fox Emily M. , Miller Todd W. , Balko Justin M. , Kuba Maria G. , Sánchez Violeta , Smith R. Adam , Liu Shuying , González-Angulo Ana María , Mills Gordon B. , Ye Fei , Shyr Yu , Manning H. Charles , Buck Elizabeth , Arteaga Carlos L.
Published: March 2023

PDF file - 376K
Supplementary Figure Legends 1-5 from Thrombospondin-1 Triggers Cell Migration and Development of Advanced Prostate Tumors
Authors: Firlej Virginie , Mathieu Jacques R.R. , Gilbert Cristèle , Lemonnier Loïc , Nakhlé Jessica , Gallou-Kabani Catherine , Guarmit Basma , Morin Aurélie , Prevarskaya Natalia , Delongchamps Nicolas Barry , Cabon Florence
Published: March 2023

PDF file - 47K
Supplementary Figures 1-6, Table 1 from Cell-Permeable NM23 Blocks the Maintenance and Progression of Established Pulmonary Metastasis
Authors: Lim Junghee , Jang Giyong , Kang Seeun , Lee Guewha , Nga Do Thi Thuy , Phuong Do Thi Lan , Kim Hyuncheol , El-Rifai Wael , Ruley H. Earl , Jo Daewoong
Published: March 2023

PDF file - 842K
Supplementary Data 9 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Authors: Mamessier Emilie , Sylvain Aude , Bertucci François , Castellano Rémy , Finetti Pascal , Houvenaeghel Gilles , Charaffe-Jaufret Emmanuelle , Birnbaum Daniel , Moretta Alessandro , Olive Daniel
Published: March 2023

PDF file - 75K, FVB control mice (n=6, light grey bars) and MMTV-Neu mice (n=6, dark grey bars) were followed from 3 months of age until tumor occurrence, and a Kaplan-Meier curve was established to determine tumor-free survival. Arrows indicate when the samples were collected. Mice were sacrificed during the last sample (VI).
Supplementary Data 8 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Authors: Mamessier Emilie , Sylvain Aude , Bertucci François , Castellano Rémy , Finetti Pascal , Houvenaeghel Gilles , Charaffe-Jaufret Emmanuelle , Birnbaum Daniel , Moretta Alessandro , Olive Daniel
Published: March 2023

PDF file - 39K, NK-cell phenotypes after exposition to breast tumor cells. NKG2D, NKp30 and DNAM-1 MFI values without, or after direct or indirect exposition to breast cancer cell lines. A paired nonparametric Wilcoxon t-test was used to evaluate the significance of the variations observed in exposed NK cells compared to non-exposed NK-cells. Only p-values<0.05 were considered as significant. p<0.05 = *; p�0.005 = **; p�0.0005 = ***.
Supplementary Figure 4 from Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells
Authors: Terme Magali , Ullrich Evelyn , Aymeric Laetitia , Meinhardt Kathrin , Coudert Jérôme D. , Desbois Mélanie , Ghiringhelli François , Viaud Sophie , Ryffel Bernard , Yagita Hideo , Chen Lieping , Mécheri Salaheddine , Kaplanski Gilles , Prévost-Blondel Armelle , Kato Masashi , Schultze Joachim L. , Tartour Eric , Kroemer Guido , Degli-Esposti Mariapia , Chaput Nathalie , Zitvogel Laurence
Published: March 2023

PDF file - 111K, Phenotypic features of Kit+ NK cells compared with Kit- NK cells
Supplementary Data 3 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Authors: Mamessier Emilie , Sylvain Aude , Bertucci François , Castellano Rémy , Finetti Pascal , Houvenaeghel Gilles , Charaffe-Jaufret Emmanuelle , Birnbaum Daniel , Moretta Alessandro , Olive Daniel
Published: March 2023

PDF file - 47K, Breast cancer cell lines known features (Perou and Sorlie cell lines classification, ERBB2 status, estrogen and progesterone expression, Phenotype of the stem cell population, HLA-C genotype and allotype).
Supplementary Figure 1 from Cancer-Induced Immunosuppression: IL-18–Elicited Immunoablative NK Cells
Authors: Terme Magali , Ullrich Evelyn , Aymeric Laetitia , Meinhardt Kathrin , Coudert Jérôme D. , Desbois Mélanie , Ghiringhelli François , Viaud Sophie , Ryffel Bernard , Yagita Hideo , Chen Lieping , Mécheri Salaheddine , Kaplanski Gilles , Prévost-Blondel Armelle , Kato Masashi , Schultze Joachim L. , Tartour Eric , Kroemer Guido , Degli-Esposti Mariapia , Chaput Nathalie , Zitvogel Laurence
Published: March 2023

PDF file - 87K, Kit+ CD11b- NK cells expand in lymphoid organs of mice bearing different types of tumors
Supplementary Data 1 from Human Breast Tumor Cells Induce Self-Tolerance Mechanisms to Avoid NKG2D-Mediated and DNAM-Mediated NK Cell Recognition
Authors: Mamessier Emilie , Sylvain Aude , Bertucci François , Castellano Rémy , Finetti Pascal , Houvenaeghel Gilles , Charaffe-Jaufret Emmanuelle , Birnbaum Daniel , Moretta Alessandro , Olive Daniel
Published: March 2023

PDF file - 320K, Supplemental Data 1: Ligands and receptors respectively expressed by tumor and NK-cells. Natural killer (NK) cells are components of the innate immune system that play a central role against tumor cells. They have an innate ability to distinguish normal from "modified" cells, such as cancer cells, through a broad range of activating and inhibitory receptors. These receptors act like little sensors of the malignant self (Moretta et al, 2006); the integration of these opposite signals determines whether an NK-cell will eliminate a potential target or not. NK-cell activating receptors are the natural cytotoxicity receptors (NKp30, NKp46 and NKp44) and NKG2D. They recognize various ligands expressed by transformed cells and/or stressed or activated cells. To date, NKp30 has two described ligands, B7H6 and BAT3. NKG2D can bind MICA, MICB and the members of the ULBP family. The ligand(s) of NKp46 or NKp44 are unknown. The main NK-cell inhibitory receptors are the killer immunoglobulin receptors (KIRs) and NKG2A (Moretta et al., 1995 & 2001), which recognize members of the HLA-I family expressed by normal cells, respectively HLA-A, -B or -C for the KIRs and HLA-E for NKG2A. The signal is fine-tuned by co-activators such as DNAM-1, CD2, NKp80, 2B4, NTBA and co-inhibitors such as the CD85 family, B7-H3 or LAIR. Among co-activator receptors, DNAM-1 binds the heterodimer PVR/Nectin2 receptors, CD2 binds CD58, NTBA binds another NTBA molecule, and 2B4 binds CD48. The co-inhibitory receptors from the CD85 family bind HLA-I molecules, while ligands of the LAIR family and B7H3 are still unknown.
Supplementary Figures 1-2 from PGE2-Induced CXCL12 Production and CXCR4 Expression Controls the Accumulation of Human MDSCs in Ovarian Cancer Environment
Authors: Obermajer Nataša , Muthuswamy Ravikumar , Odunsi Kunle , Edwards Robert P. , Kalinski Pawel
Published: March 2023

PDF file - 175K
Supplementary Methods, Figures 1-6, Table 1 from Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair
Authors: Goellner Eva M. , Grimme Bradford , Brown Ashley R. , Lin Ying-Chih , Wang Xiao-Hong , Sugrue Kelsey F. , Mitchell Leah , Trivedi Ram N. , Tang Jiang-bo , Sobol Robert W.
Published: March 2023

Supplementary Methods, Figures 1-6, Table 1 from Overcoming Temozolomide Resistance in Glioblastoma via Dual Inhibition of NAD+ Biosynthesis and Base Excision Repair
Supplementary Figure 1 from Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
Authors: Falcon Beverly L. , Barr Sharon , Gokhale Prafulla C. , Chou Jeyling , Fogarty Jennifer , Depeille Philippe , Miglarese Mark , Epstein David M. , McDonald Donald M.
Published: March 2023

Supplementary Figure 1 from Reduced VEGF Production, Angiogenesis, and Vascular Regrowth Contribute to the Antitumor Properties of Dual mTORC1/mTORC2 Inhibitors
Supplementary Figure 3 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Authors: Farnsworth Rae H. , Karnezis Tara , Shayan Ramin , Matsumoto Masataka , Nowell Cameron J. , Achen Marc G. , Stacker Steven A.
Published: March 2023

PDF file - 86K
Supplementary Figures 1-6 from Pivotal Role of Reduced let-7g Expression in Breast Cancer Invasion and Metastasis
Authors: Qian Pengxu , Zuo Zehua , Wu Zhengsheng , Meng Xianyi , Li Gaopeng , Wu Zhengzhou , Zhang Weijie , Tan Sheng , Pandey Vijay , Yao Yandan , Wang Puyue , Zhao Liqing , Wang Jun , Wu Qiang , Song Erwei , Lobie Peter E. , Yin Zhinan , Zhu Tao
Published: March 2023

PDF file - 2.16MB
Supplementary Figure 1 from A Role for Bone Morphogenetic Protein-4 in Lymph Node Vascular Remodeling and Primary Tumor Growth
Authors: Farnsworth Rae H. , Karnezis Tara , Shayan Ramin , Matsumoto Masataka , Nowell Cameron J. , Achen Marc G. , Stacker Steven A.
Published: March 2023

PDF file - 98K
Supplementary Movie 2 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
Authors: Timpson Paul , McGhee Ewan J. , Morton Jennifer P. , von Kriegsheim Alex , Schwarz Juliane P. , Karim Saadia A. , Doyle Brendan , Quinn Jean A. , Carragher Neil O. , Edward Mike , Olson Michael F. , Frame Margaret C. , Brunton Valerie G. , Sansom Owen J. , Anderson Kurt I.
Published: March 2023

Supplementary Movie 2 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
Supplementary Figure 5 from Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer
Authors: Yoo Young A. , Kang Myoung Hee , Lee Hyun Joo , Kim Baek-hui , Park Jong Kuk , Kim Hyun Koo , Kim Jun Suk , Oh Sang Cheul
Published: March 2023

PDF file - 107K
Supplementary Figure 7 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
Authors: Timpson Paul , McGhee Ewan J. , Morton Jennifer P. , von Kriegsheim Alex , Schwarz Juliane P. , Karim Saadia A. , Doyle Brendan , Quinn Jean A. , Carragher Neil O. , Edward Mike , Olson Michael F. , Frame Margaret C. , Brunton Valerie G. , Sansom Owen J. , Anderson Kurt I.
Published: March 2023

Supplementary Figure 7 from Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53
Supplementary Figure 2 from Sonic Hedgehog Pathway Promotes Metastasis and Lymphangiogenesis via Activation of Akt, EMT, and MMP-9 Pathway in Gastric Cancer
Authors: Yoo Young A. , Kang Myoung Hee , Lee Hyun Joo , Kim Baek-hui , Park Jong Kuk , Kim Hyun Koo , Kim Jun Suk , Oh Sang Cheul
Published: March 2023

PDF file - 133K
Supplementary Figures 1-2 from Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGFβ1 in Melanoma Enhances Tumor Infiltration and Immunosuppression
Authors: Díaz-Valdés Nancy , Basagoiti María , Dotor Javier , Aranda Fernando , Monreal Iñaki , Riezu-Boj José Ignacio , Borrás-Cuesta Francisco , Sarobe Pablo , Feijoó Esperanza
Published: March 2023

Supplementary Figures 1-2 from Induction of Monocyte Chemoattractant Protein-1 and Interleukin-10 by TGFβ1 in Melanoma Enhances Tumor Infiltration and Immunosuppression
Supplementary Figure 4 from FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines
Authors: Kreiter Sebastian , Diken Mustafa , Selmi Abderraouf , Diekmann Jan , Attig Sebastian , Hüsemann Yves , Koslowski Michael , Huber Christoph , Türeci Özlem , Sahin Ugur
Published: March 2023

PDF file - 99K
Supplementary Figure 3 from FLT3 Ligand Enhances the Cancer Therapeutic Potency of Naked RNA Vaccines
Authors: Kreiter Sebastian , Diken Mustafa , Selmi Abderraouf , Diekmann Jan , Attig Sebastian , Hüsemann Yves , Koslowski Michael , Huber Christoph , Türeci Özlem , Sahin Ugur
Published: March 2023

PDF file - 1.40 MB
Supplementary Figure 1 from CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis
Authors: Thomas Shibu , Harding Michael A. , Smith Steven C. , Overdevest Jonathan B. , Nitz Matthew D. , Frierson Henry F. , Tomlins Scott A. , Kristiansen Glen , Theodorescu Dan
Published: March 2023

PDF file - 25K, Detail of the gene signature of Ral-dependent transcription and molecular concepts
Supplementary Figure Legends 1-5 from Mammalian Sterile 20–like Kinase 1 Suppresses Lymphoma Development by Promoting Faithful Chromosome Segregation
Authors: Kim Tae-Shin , Lee Da-Hye , Kim Sang Kyum , Shin So Youn , Seo Eul-Ju , Lim Dae-Sik
Published: March 2023

PDF file - 32K
Supplementary Figure 2 from A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
Authors: Waaler Jo , Machon Ondrej , Tumova Lucie , Dinh Huyen , Korinek Vladimir , Wilson Steven Ray , Paulsen Jan Erik , Pedersen Nina Marie , Eide Tor J. , Machonova Olga , Gradl Dietmar , Voronkov Andrey , von Kries Jens Peter , Krauss Stefan
Published: March 2023

PDF file - 77K, The figure shows full-length and uncropped Western blots of analyzed lysates from SW480 cells exposed to different concentrations of JW55 for 24 hours
Supplementary Figure 1 from A Novel Tankyrase Inhibitor Decreases Canonical Wnt Signaling in Colon Carcinoma Cells and Reduces Tumor Growth in Conditional APC Mutant Mice
Authors: Waaler Jo , Machon Ondrej , Tumova Lucie , Dinh Huyen , Korinek Vladimir , Wilson Steven Ray , Paulsen Jan Erik , Pedersen Nina Marie , Eide Tor J. , Machonova Olga , Gradl Dietmar , Voronkov Andrey , von Kries Jens Peter , Krauss Stefan
Published: March 2023

PDF file - 160K, Determination of IC50-values in HEK293 cells (ST-Luc) and biochemical assays (TNKS1/2 and PARP) using XLfit
Supplementary Figures 1-2 from Pocket Proteins Suppress Head and Neck Cancer
Authors: Shin Myeong-Kyun , Pitot Henry C. , Lambert Paul F.
Published: March 2023

PDF file - 473K
Supplementary Figure 7 from Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity
Authors: Pietra Gabriella , Manzini Claudia , Rivara Silvia , Vitale Massimo , Cantoni Claudia , Petretto Andrea , Balsamo Mirna , Conte Romana , Benelli Roberto , Minghelli Simona , Solari Nicola , Gualco Marina , Queirolo Paola , Moretta Lorenzo , Mingari Maria Cristina
Published: March 2023

PDF file - 48K
Supplementary Materials and Methods, Figure Legends 1-6 from miR-103/107 Promote Metastasis of Colorectal Cancer by Targeting the Metastasis Suppressors DAPK and KLF4
Authors: Chen Hsin-Yi , Lin Yu-Min , Chung Hsiang-Ching , Lang Yaw-Dong , Lin Ching-Jung , Huang John , Wang Wei-Chi , Lin Feng-Mao , Chen Zhen , Huang Hsien-Da , Shyy John Y.-J. , Liang Jin-Tung , Chen Ruey-Hwa
Published: March 2023

PDF file - 52K, Supplementary materials includes statistical analysis, antibodies and reagent information, supplementary references, and supplementary figure legend
Supplementary Figure 1 from Melanoma Cells Inhibit Natural Killer Cell Function by Modulating the Expression of Activating Receptors and Cytolytic Activity
Authors: Pietra Gabriella , Manzini Claudia , Rivara Silvia , Vitale Massimo , Cantoni Claudia , Petretto Andrea , Balsamo Mirna , Conte Romana , Benelli Roberto , Minghelli Simona , Solari Nicola , Gualco Marina , Queirolo Paola , Moretta Lorenzo , Mingari Maria Cristina
Published: March 2023

PDF file - 43K
Supplementary Figure 2 from Differential Effects of Polymorphic Alleles of FGF Receptor 4 on Colon Cancer Growth and Metastasis
Authors: Heinzle Christine , Gsur Andrea , Hunjadi Monika , Erdem Zeynep , Gauglhofer Christine , Stättner Stefan , Karner Josef , Klimpfinger Martin , Wrba Friedrich , Reti Andrea , Hegedus Balazs , Baierl Andreas , Grasl-Kraupp Bettina , Holzmann Klaus , Grusch Michael , Berger Walter , Marian Brigitte
Published: March 2023

PDF file - 56K, Describes FGFR4 overexpression on RNA and protein level for the stable transfectants used
Supplementary Table 2 from Definition of Genetic Events Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem/Progenitor Cells
Authors: Hertwig Falk , Meyer Katharina , Braun Sebastian , Ek Sara , Spang Rainer , Pfenninger Cosima V. , Artner Isabella , Prost Gaëlle , Chen Xinbin , Biegel Jaclyn A. , Judkins Alexander R. , Englund Elisabet , Nuber Ulrike A.
Published: March 2023

XLS file - 147K, Six groups of genes (A-F), which show the highest correlation to one of the three tumor types
Supplementary Methods, Figure Legends 1-7 from RANK Induces Epithelial–Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis
Authors: Palafox Marta , Ferrer Irene , Pellegrini Pasquale , Vila Sergi , Hernandez-Ortega Sara , Urruticoechea Ander , Climent Fina , Soler Maria Teresa , Muñoz Purificación , Viñals Francesc , Tometsko Mark , Branstetter Dan , Dougall William C. , González-Suárez Eva
Published: March 2023

PDF file - 167K
Supplementary Figure 7 from RANK Induces Epithelial–Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis
Authors: Palafox Marta , Ferrer Irene , Pellegrini Pasquale , Vila Sergi , Hernandez-Ortega Sara , Urruticoechea Ander , Climent Fina , Soler Maria Teresa , Muñoz Purificación , Viñals Francesc , Tometsko Mark , Branstetter Dan , Dougall William C. , González-Suárez Eva
Published: March 2023

PDF file - 89K, RANK/RANKL expression significantly associates with tumor subtype and lymph node metastasis
Supplementary Figure 1 from RANK Induces Epithelial–Mesenchymal Transition and Stemness in Human Mammary Epithelial Cells and Promotes Tumorigenesis and Metastasis
Authors: Palafox Marta , Ferrer Irene , Pellegrini Pasquale , Vila Sergi , Hernandez-Ortega Sara , Urruticoechea Ander , Climent Fina , Soler Maria Teresa , Muñoz Purificación , Viñals Francesc , Tometsko Mark , Branstetter Dan , Dougall William C. , González-Suárez Eva
Published: March 2023

PDF file - 91K, RANK is expressed and active in MCF10A cells
Supplementary Figure 2 from Platelets and P-Selectin Control Tumor Cell Metastasis in an Organ-Specific Manner and Independently of NK Cells
Authors: Coupland Lucy A. , Chong Beng H. , Parish Christopher R.
Published: March 2023

PDF file, 430K, 4T1.2 subcutaneous tumor growth in platelet-deficient mice.
Supplementary Figure 7 from Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment
Authors: Zhang Yan , Daquinag Alexes C. , Amaya-Manzanares Felipe , Sirin Olga , Tseng Chieh , Kolonin Mikhail G.
Published: March 2023

PDF file - 406K, Tumor cellularity and desmoplasia in obese and lean animals
Supplementary Figure 4 from Frequent PVT1 Rearrangement and Novel Chimeric Genes PVT1-NBEA and PVT1-WWOX Occur in Multiple Myeloma with 8q24 Abnormality
Authors: Nagoshi Hisao , Taki Tomohiko , Hanamura Ichiro , Nitta Masakazu , Otsuki Takemi , Nishida Kazuhiro , Okuda Keiko , Sakamoto Natsumi , Kobayashi Satoru , Yamamoto-Sugitani Mio , Tsutsumi Yasuhiko , Kobayashi Tsutomu , Matsumoto Yosuke , Horiike Shigeo , Kuroda Junya , Taniwaki Masafumi
Published: March 2023

PDF file - 467K, Genome copy number alterations of translocation partner loci
Supplementary Figure 3 from Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment
Authors: Zhang Yan , Daquinag Alexes C. , Amaya-Manzanares Felipe , Sirin Olga , Tseng Chieh , Kolonin Mikhail G.
Published: March 2023

PDF file - 2.2MB, Identification of ASC among mouse PBMC leukocytes
Supplementary Tables 1-4 from A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs
Authors: Kim Tae-Min , Huang Wei , Park Richard , Park Peter J. , Johnson Mark D.
Published: March 2023

Supplementary Tables 1-4 from A Developmental Taxonomy of Glioblastoma Defined and Maintained by MicroRNAs
Supplementary Figure 5 from A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D
Authors: Ting Huei-Ju , Yasmin-Karim Sayeda , Yan Shian-Jang , Hsu Jong-Wei , Lin Tzu-Hua , Zeng Weisi , Messing James , Sheu Tzong-Jeng , Bao Bo-Ying , Li Willis X. , Messing Edward , Lee Yi-Fen
Published: March 2023

PDF file - 275K
Supplementary Figure 3 from A Positive Feedback Signaling Loop between ATM and the Vitamin D Receptor Is Critical for Cancer Chemoprevention by Vitamin D
Authors: Ting Huei-Ju , Yasmin-Karim Sayeda , Yan Shian-Jang , Hsu Jong-Wei , Lin Tzu-Hua , Zeng Weisi , Messing James , Sheu Tzong-Jeng , Bao Bo-Ying , Li Willis X. , Messing Edward , Lee Yi-Fen
Published: March 2023

PDF file - 116K
Supplementary Figure 1 from Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer–Initiating Cells
Authors: Ohata Hirokazu , Ishiguro Tatsuya , Aihara Yuki , Sato Ai , Sakai Hiroaki , Sekine Shigeki , Taniguchi Hirokazu , Akasu Takayuki , Fujita Shin , Nakagama Hitoshi , Okamoto Koji
Published: March 2023

PDF file - 261K, ROCK inhibitors greatly improve sphere-forming efficiency from primary colon cancer cells
Supplementary Figure 4 from CD44s Regulates the TGF-β–Mediated Mesenchymal Phenotype and Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
Authors: Mima Kosuke , Okabe Hirohisa , Ishimoto Takatsugu , Hayashi Hiromitsu , Nakagawa Shigeki , Kuroki Hideyuki , Watanabe Masayuki , Beppu Toru , Tamada Mayumi , Nagano Osamu , Saya Hideyuki , Baba Hideo
Published: March 2023

PDF file - 1.4MB, TGF-beta signaling did not induce the expression of CD133 in HCC cells
Supplementary Figure Legends 1-6 from Histone Deacetylase Inhibitors Influence Chemotherapy Transport by Modulating Expression and Trafficking of a Common Polymorphic Variant of the ABCG2 Efflux Transporter
Authors: Basseville Agnes , Tamaki Akina , Ierano Caterina , Trostel Shana , Ward Yvona , Robey Robert W. , Hegde Ramanujan S. , Bates Susan E.
Published: March 2023

PDF file - 82K
Supplementary Figure 1 from Candidate Pathways for Promoting Differentiation or Quiescence of Oligodendrocyte Progenitor-like Cells in Glioma
Authors: Dougherty Joseph D. , Fomchenko Elena I. , Akuffo Afua A. , Schmidt Eric , Helmy Karim Y. , Bazzoli Elena , Brennan Cameron W. , Holland Eric C. , Milosevic Ana
Published: March 2023

PDF file - 1.1MB, Histological and immunocytochemical characterization of the RACS-PDGFb-induced tumors in Ntv-a-Olig2-bacTRAP mice resemble human grade IV malignant glioblastoma. A-A1: Low magnification image of the hematoxylin and eosin stained cryostat section of the large, high grade tumor excised from the Ntv-a/ink4a/arf+/- Olig2::EgfpL10a mouse. Higher magnification of the boxed area in A shows similarities with the human GBM, including pseudopalisades (arrows), surrounding areas of necrosis (asterisk), and vascular proliferation (arrowheads). B: Large number of Olig2-positive cells in the PDGF-B-induced glioblastoma on the Ntv-a/ink4a/arf+/- Olig2: EgfpL10a background are labeled with the antibody against proliferation marker Ki67, confirming high proliferative index of tumor cells
Supplementary Figure 3 from Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response
Authors: Weaver Zoë , Difilippantonio Simone , Carretero Julian , Martin Philip L. , El Meskini Rajaa , Iacovelli Anthony J. , Gumprecht Michelle , Kulaga Alan , Guerin Theresa , Schlomer Jerome , Baran Maureen , Kozlov Serguei , McCann Thomas , Mena Salvador , Al-Shahrour Fatima , Alexander Danny , Wong Kwok-Kin , Van Dyke Terry
Published: March 2023

PDF file - 117K, Reduction of p-EGFR and p-S6 in BIBW 2992 and rapamycin-treated lungs at 4, 8, and 24 hours post-treatment
Supplementary Table 1 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Authors: Zhang Mary , Mathur Aarti , Zhang Yuwei , Xi Sichuan , Atay Scott , Hong Julie A. , Datrice Nicole , Upham Trevor , Kemp Clinton D. , Ripley R. Taylor , Wiegand Gordon , Avital Itzak , Fetsch Patricia , Mani Haresh , Zlott Daniel , Robey Robert , Bates Susan E. , Li Xinmin , Rao Mahadev , Schrump David S.
Published: March 2023

PDF file - 76K, TaqMan and ChIP Primers, and Antibodies
Supplementary Figure 2 from Mithramycin Represses Basal and Cigarette Smoke–Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells
Authors: Zhang Mary , Mathur Aarti , Zhang Yuwei , Xi Sichuan , Atay Scott , Hong Julie A. , Datrice Nicole , Upham Trevor , Kemp Clinton D. , Ripley R. Taylor , Wiegand Gordon , Avital Itzak , Fetsch Patricia , Mani Haresh , Zlott Daniel , Robey Robert , Bates Susan E. , Li Xinmin , Rao Mahadev , Schrump David S.
Published: March 2023

PDF file - 87K, Bar graph depicting total number of differentially expressed genes, as well as relative numbers induced or repressed under various treatment conditions
Supplementary Figure Legends 1-9 from Mitigating Age-Related Immune Dysfunction Heightens the Efficacy of Tumor Immunotherapy in Aged Mice
Authors: Hurez Vincent , Daniel Benjamin J. , Sun Lishi , Liu Ai-Jie , Ludwig Sara M. , Kious Mark J. , Thibodeaux Suzanne R. , Pandeswara Srilakshmi , Murthy Kruthi , Livi Carolina B. , Wall Shawna , Brumlik Michael J. , Shin Tahiro , Zhang Bin , Curiel Tyler J.
Published: March 2023

PDF file - 79K
Supplementary Figure 7 from Metastasis Suppressor NM23-H1 Promotes Repair of UV-Induced DNA Damage and Suppresses UV-Induced Melanomagenesis
Authors: Jarrett Stuart G. , Novak Marian , Dabernat Sandrine , Daniel Jean-Yves , Mellon Isabel , Zhang Qingbei , Harris Nathan , Ciesielski Michael J. , Fenstermaker Robert A. , Kovacic Diane , Slominski Andrzej , Kaetzel David M.
Published: March 2023

PDF file - 180K
Supplementary Figure 1 from Cancer Angiogenesis Induced by Kaposi Sarcoma–Associated Herpesvirus Is Mediated by EZH2
Authors: He Meilan , Zhang Wei , Bakken Thomas , Schutten Melissa , Toth Zsolt , Jung Jae U. , Gill Parkash , Cannon Mark , Gao Shou-Jiang
Published: March 2023

PDF file - 101K, KSHV infection converts BOEC cells into spindle shape, and upregulates the expression of lymphatic endothelial markers
Supplementary Figure 5 from Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis
Authors: Zhang Yi , Cheng Yan , Ren Xingcong , Hori Tsukasa , Huber-Keener Kathryn J. , Zhang Li , Yap Kai Lee , Liu David , Shantz Lisa , Qin Zheng-Hong , Zhang Suping , Wang Jianrong , Wang Hong-Gang , Shih Ie-Ming , Yang Jin-Ming
Published: March 2023

PDF file - 65K, Effects of NAC1 on transcription of DeltaNp63 in MEFs
Supplementary Figures 1-5 from Autoregulatory Mechanisms of Phosphorylation of Checkpoint Kinase 1
Authors: Wang Jingna , Han Xiangzi , Zhang Youwei
Published: March 2023

PDF file - 593K, S1 (A) HEK293T cells were transfected with Myc-Chk1 WT or D148A mutant for 48 hr, treated with 2 �M MG132 for additional 12 hr, and immunoblotted with indicated antibodies. (B) Alignment of the domain from CM1 to the distal C-terminus of Chk1 from different species. Figure S2 (A) HEK293T cells were transfected with Myc-tagged Chk1 FL, N- or Cterminal fragments for 48 hr, immunoblotted with indicated antibodies. (B) Schematic diagram of generating GFP-tagged Chk1 C terminal fragments. (C) HEK293T cells were transfected with Myc-Chk1 N-terminus and GFP-tagged Chk1 C-terminal fragments for 48 hr, immunoprecipitated with anti- Myc antibodies and immunoblotted with anti-GFP antibodies. (D) Myc-Chk1 WT or L449R mutant proteins were produced by in vitro transcription and translation, and used to perform in vitro kinase assay with the GST-Cdc25C (200-256) as the substrate. Figure S3 Constitutive activation of Chk1 inhibits S phase progression. Figure S4 HeLa Tet/Off cells were transfected and treated as shown in Figure S3A, cells were collected and cell cycle profile of GFP-positive cells was determined by flow cytometry. Figure S5 Models for Chk1 phosphorylation under different situations
Supplementary Figure 3 from Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis
Authors: Zhang Yi , Cheng Yan , Ren Xingcong , Hori Tsukasa , Huber-Keener Kathryn J. , Zhang Li , Yap Kai Lee , Liu David , Shantz Lisa , Qin Zheng-Hong , Zhang Suping , Wang Jianrong , Wang Hong-Gang , Shih Ie-Ming , Yang Jin-Ming
Published: March 2023

PDF file - 190K, Silencing of p21 expression inhibits senescence induction in NAC1-deficient tumor cells treated with irradiation
Supplementary Methods, Figure Legends 1-11 from Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death
Authors: Cheng Gang , Zielonka Jacek , Dranka Brian P. , McAllister Donna , Mackinnon A. Craig , Joseph Joy , Kalyanaraman Balaraman
Published: March 2023

PDF file - 115K
Supplementary Table 1 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models
Authors: Zhang Qiuyang , Liu Sen , Ge Dongxia , Zhang Qingsong , Xue Yun , Xiong Zhenggang , Abdel-Mageed Asim B. , Myers Leann , Hill Steven M. , Rowan Brian G. , Sartor Oliver , Melamed Jonathan , Chen Zhenbang , You Zongbing
Published: March 2023

PDF file - 63K, PCR Primer Sequences
Supplementary Figure 2 from Interleukin-17 Promotes Formation and Growth of Prostate Adenocarcinoma in Mouse Models
Authors: Zhang Qiuyang , Liu Sen , Ge Dongxia , Zhang Qingsong , Xue Yun , Xiong Zhenggang , Abdel-Mageed Asim B. , Myers Leann , Hill Steven M. , Rowan Brian G. , Sartor Oliver , Melamed Jonathan , Chen Zhenbang , You Zongbing
Published: March 2023

PDF file - 6.6MB, Immunohistochemical staining of laminin in whole prostate sections.
Supplementary Figure Legends 1-8 from LIGHT Delivery to Tumors by Mesenchymal Stem Cells Mobilizes an Effective Antitumor Immune Response
Authors: Zou Weibin , Zheng Huilin , He Tong-Chuan , Chang Jinjia , Fu Yang-Xin , Fan Weimin
Published: March 2023

PDF file - 164K
Supplementary Methods, Figure Legends 1-6 from Radiotherapy Increases the Permissiveness of Established Mammary Tumors to Rejection by Immunomodulatory Antibodies
Authors: Verbrugge Inge , Hagekyriakou Jim , Sharp Leslie L. , Galli Mara , West Alison , McLaughlin Nicole M. , Duret Hélène , Yagita Hideo , Johnstone Ricky W. , Smyth Mark J. , Haynes Nicole M.
Published: March 2023

PDF file - 119K, Detailed description of the Supplementary Materials and Methods, Experimental 4T1.2 in vivo Data and Figure Legends
Supplementary Figure 7 from NAC1 Is an Actin-Binding Protein That Is Essential for Effective Cytokinesis in Cancer Cells
Authors: Yap Kai Lee , Fraley Stephanie I. , Thiaville Michelle M. , Jinawath Natini , Nakayama Kentaro , Wang Jianlong , Wang Tian-Li , Wirtz Denis , Shih Ie-Ming
Published: March 2023

PDF file - 76K, Supporting data of quantitative binding assay
Supplementary Figure 5 from NAC1 Is an Actin-Binding Protein That Is Essential for Effective Cytokinesis in Cancer Cells
Authors: Yap Kai Lee , Fraley Stephanie I. , Thiaville Michelle M. , Jinawath Natini , Nakayama Kentaro , Wang Jianlong , Wang Tian-Li , Wirtz Denis , Shih Ie-Ming
Published: March 2023

PDF file - 63K, mOSE cells of NAC1 knockout mouse
Supplementary Video 4 from RALBP1/RLIP76 Depletion in Mice Suppresses Tumor Growth by Inhibiting Tumor Neovascularization
Authors: Lee Seunghyung , Wurtzel Jeremy G. T. , Singhal Sharad S. , Awasthi Sanjay , Goldfinger Lawrence E.
Published: March 2023

MOV file - 695K, 3D muCT reconstruction of the vasculature in a LLC tumor derived in a RLIP76-/- mouse
Supplementary Figure Legends 1-6 from Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-Mediated GLUT3 Transcription
Authors: Ha Tae-Kyu , Her Nam-Gu , Lee Min-Goo , Ryu Byung-Kyu , Lee Jin-Hee , Han Jikhyon , Jeong Seong-In , Kang Min-Ju , Kim Nam-Hoon , Kim Hyo-Jong , Chi Sung-Gil
Published: March 2023

PDF file- 18K
Supplementary Figure 3 from Caveolin-1 Increases Aerobic Glycolysis in Colorectal Cancers by Stimulating HMGA1-Mediated GLUT3 Transcription
Authors: Ha Tae-Kyu , Her Nam-Gu , Lee Min-Goo , Ryu Byung-Kyu , Lee Jin-Hee , Han Jikhyon , Jeong Seong-In , Kang Min-Ju , Kim Nam-Hoon , Kim Hyo-Jong , Chi Sung-Gil
Published: March 2023

PDF file- 128K, Activation of p53 by CAV1 depletion
Supplementary Table 4 from Dual Targeting of the Akt/mTOR Signaling Pathway Inhibits Castration-Resistant Prostate Cancer in a Genetically Engineered Mouse Model
Authors: Floc'h Nicolas , Kinkade Carolyn Waugh , Kobayashi Takashi , Aytes Alvaro , Lefebvre Celine , Mitrofanova Antonina , Cardiff Robert D. , Califano Andrea , Shen Michael M. , Abate-Shen Cory
Published: March 2023

XLS file, 239K, Differentially expressed gene set data for the intact mice.
Supplementary Table 4 from ESE3/EHF Controls Epithelial Cell Differentiation and Its Loss Leads to Prostate Tumors with Mesenchymal and Stem-like Features
Authors: Albino Domenico , Longoni Nicole , Curti Laura , Mello-Grand Maurizia , Pinton Sandra , Civenni Gianluca , Thalmann George , D'Ambrosio Gioacchino , Sarti Manuela , Sessa Fausto , Chiorino Giovanna , Catapano Carlo V. , Carbone Giuseppina M.
Published: March 2023

XLS file - 156K, Genes up- and down- regulated in ESE3low tumors compared to all tumors (Q<0.05)
Supplementary Figure 2 from Augmentation of Therapeutic Responses in Melanoma by Inhibition of IRAK-1,-4
Authors: Srivastava Ratika , Geng Degui , Liu Yingjia , Zheng Liqin , Li Zhaoyang , Joseph Mary Ann , McKenna Colleen , Bansal Navneeta , Ochoa Augusto , Davila Eduardo
Published: March 2023

PDF file - 48K, Inhibiting IRAK-1/-4 abrogates the effects of TLR1-TLR2 agonist in melanoma cells
Supplementary Data 2 from An NMR Metabolomics Approach for the Diagnosis of Leptomeningeal Carcinomatosis
Authors: Cho Hye Rim , Wen He , Ryu Young Jin , An Yong Jin , Kim Hyo Cheol , Moon Woo Kyung , Han Moon Hee , Park Sunghyouk , Choi Seung Hong
Published: March 2023

PDF file - 133K, The OPLS-DA method
Supplementary Table 2 from Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis
Authors: van der Weyden Louise , Papaspyropoulos Angelos , Poulogiannis George , Rust Alistair G. , Rashid Mamunur , Adams David J. , Arends Mark J. , O'Neill Eric
Published: March 2023

PDF file - 54K, Details of the microarray expression datasets used to analyse RASSF1 and RUNX2 expression levels
Supplementary Figure 6 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: March 2023

PDF file - 666K, Influence of LBW242 treatment on the activation of the intrinsic and extrinsic apoptosis pathways in MYCN amplified Kelly cells.
Supplementary Figure 1 from Loss of Rassf1a Synergizes with Deregulated Runx2 Signaling in Tumorigenesis
Authors: van der Weyden Louise , Papaspyropoulos Angelos , Poulogiannis George , Rust Alistair G. , Rashid Mamunur , Adams David J. , Arends Mark J. , O'Neill Eric
Published: March 2023

PDF file - 64K, U2OS cells were transfected with either non-targeting (NT) or siRNA RUNX2 as above, in the presence or absence of siRNA targeting RASSF1A, and endogenous YAP1 immunoprecipitates were blotted with the indicated antibodies
Supplementary Tables 2-4 from Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
Authors: Liu Can , Kelnar Kevin , Vlassov Alexander V. , Brown David , Wang Junchen , Tang Dean G.
Published: March 2023

PDF file - 190K
Supplementary Table 1 from Distinct microRNA Expression Profiles in Prostate Cancer Stem/Progenitor Cells and Tumor-Suppressive Functions of let-7
Authors: Liu Can , Kelnar Kevin , Vlassov Alexander V. , Brown David , Wang Junchen , Tang Dean G.
Published: March 2023

PDF file - 72K, HPCa sample information
Supplementary Figure 1 from Smac Mimetic LBW242 Sensitizes XIAP-Overexpressing Neuroblastoma Cells for TNF-α–Independent Apoptosis
Authors: Eschenburg Georg , Eggert Angelika , Schramm Alexander , Lode Holger N. , Hundsdoerfer Patrick
Published: March 2023

PDF file - 656K, Induction of apoptosis in NXS2 neuroblastoma cells by LBW242 in combination with etoposide or vincristine.
Supplementary Figure 6 from Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development
Authors: Okada Hikari , Honda Masao , Campbell Jean S. , Sakai Yoshio , Yamashita Taro , Takebuchi Yuuki , Hada Kazuhiro , Shirasaki Takayoshi , Takabatake Riuta , Nakamura Mikiko , Sunagozaka Hajime , Tanaka Takuji , Fausto Nelson , Kaneko Shuichi
Published: March 2023

PDF file - 133K, (A) Western blotting of PDGFR-o, POGFR-p, VEGFR2, p-AKT, p-ERK112 and GAPDH expression in Huh-7, HepG2, NH3T3, HLE, HUVEC and Lx-2 cells treated with peretinoin. (B) RTD-peR evaluation of collagen 1a2 in Lx-2, HLE and HUh-7 cells with or without peretinoin (20 IJM) (n=3). (C) Time course of PDGF-a, Sp1, c-Jun and p-c-Jun after peretinoin treatment in HUh-7 cells.
Supplementary Figure 3 from Acyclic Retinoid Targets Platelet-Derived Growth Factor Signaling in the Prevention of Hepatic Fibrosis and Hepatocellular Carcinoma Development
Authors: Okada Hikari , Honda Masao , Campbell Jean S. , Sakai Yoshio , Yamashita Taro , Takebuchi Yuuki , Hada Kazuhiro , Shirasaki Takayoshi , Takabatake Riuta , Nakamura Mikiko , Sunagozaka Hajime , Tanaka Takuji , Fausto Nelson , Kaneko Shuichi
Published: March 2023

PDF file - 507K, Heat map of serial gene expression profiling in liver of Pdgf-c Tg mice that developed hepatic fibrosis and tumors. Differentially expressed genes clustered in a one way hierarchical method among seven grouped samples: WT mice at 20 weeks and 48 weeks, non-tumor portion of Pdgf-c Tg mouse livers fed a basal diet at 20 weeks and 48 weeks, tumor portion (Hee) of Pdgf-c Tg mouse livers fed a basal diet at 48 weeks, non-tumor portion of Pdgf-c Tg mouse livers fed with 0.06% peretinoin at 20 weeks and 48 weeks. Three large clusters (A, B and e) were obtained. Representative gene names listed on right hand side.
Supplementary Figure 5 from miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer
Authors: Majid Shahana , Dar Altaf A. , Saini Sharanjot , Arora Sumit , Shahryari Varahram , Zaman Mohd Saif , Chang Inik , Yamamura Soichiro , Tanaka Yuichiro , Deng Guoren , Dahiya Rajvir
Published: March 2023

PDF file - 967K, Depletion of Src kinase by an additional siRNA sequence
Supplementary Figure 5 from SIRT1 Pathway Dysregulation in the Smoke-Exposed Airway Epithelium and Lung Tumor Tissue
Authors: Beane Jennifer , Cheng Luis , Soldi Raffaella , Zhang Xiaohui , Liu Gang , Anderlind Christina , Lenburg Marc E. , Spira Avrum , Bild Andrea H.
Published: March 2023

PDF file, 72K, SIRT1 and PI3K pathway activation in airway epithelial cells from current and formers smokers with and without lung cancer. CEL files from the training and test set samples in GSE4115 (n=129 samples, n=29 current smokers with lung cancer, n=22 current smokers without lung cancer, n=31 former smokers with lung cancer, n=26 former smokers without lung cancer) were processed as described in the methods. The pathway signature for PI3K was re-derived using the methods described above using a compendium of oncogenic signatures including BCAT, E2F3, MYC, p63, RAS, and SRC (GSE3151 and GSE12815). PI3K pathway activation probabilities for each sample were computed using the same methodology described for SIRT1. A. There is no significant difference in SIRT1 pathway activation between patients with and without lung cancer. SIRT1 is significantly activated in current smokers compared to former smokers (p<0.001). B. PI3K is significantly activated in patients with lung cancer (p<0.001).
Supplementary Figure 2 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: March 2023

PDF file - 108K, The effective knockdown of UBC13, RAP80 or RNF168 was confirmed using western blotting
Supplementary Methods, Figure Legends 1-3 from Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy
Authors: Maas Amanda L. , Carter Shirron L. , Wileyto E. Paul , Miller Joann , Yuan Min , Yu Guoqiang , Durham Amy C. , Busch Theresa M.
Published: March 2023

PDF file - 63K
Supplementary Figure 2 from Tumor Vascular Microenvironment Determines Responsiveness to Photodynamic Therapy
Authors: Maas Amanda L. , Carter Shirron L. , Wileyto E. Paul , Miller Joann , Yuan Min , Yu Guoqiang , Durham Amy C. , Busch Theresa M.
Published: March 2023

PDF file - 3.4MB
Supplementary Methods from The CRTC1-NEDD9 Signaling Axis Mediates Lung Cancer Progression Caused by LKB1 Loss
Authors: Feng Yan , Wang Ye , Wang Zuoyun , Fang Zhaoyuan , Li Fei , Gao Yijun , Liu Hongyan , Xiao Tian , Li Fuming , Zhou Yang , Zhai Qiwei , Liu Xiaolong , Sun Yihua , Bardeesy Nabeel , Wong Kwok-kin , Chen Haiquan , Xiong Zhi-qi , Ji Hongbin
Published: March 2023

PDF file - 161K, Supplementary methods about plasmids and antibodies, immunofluorescence, soft agar assay and boyden chamber assay
Supplementary Figures 1-7, Tables 1-3 from SpliceArray Profiling of Breast Cancer Reveals a Novel Variant of NCOR2/SMRT That Is Associated with Tamoxifen Resistance and Control of ERα Transcriptional Activity
Authors: Zhang Luduo , Gong Chun , Lau Samantha L.Y. , Yang Nan , Wong Oscar G.W. , Cheung Annie N.Y. , Tsang Janice W.H. , Chan Kelvin Y.K. , Khoo Ui-Soon
Published: March 2023

PDF file - 2.2MB, Supplementary figure 1. IC 50 shows that AK47 is more resistant than its parental cell line ZR-75-1, although response to tamoxifen treatment was still observed. Supplementary figure 2. Heat map of 11 splice variants selected for further q-PCR validation Supplementary figure 3. BQ323636.1 was over-expressed in 293T and Hela cell lines to prove its predicted molecular weight Supplementary figure 4. In ER positive patients who have received tamoxifen treatment, BQ mRNA expression level is not significantly correlated with chest wall/breast relapse. Supplementary figure 5. BQ mRNA level and BQ/WT ratio correlates with ER and PR status while BQ/WT ratio correlates with "triple-negative" status. Supplementary figure 6. Schematic representation of the functional domains of NCOR2 wild type and variant BQ323636.1 and the amino acid sequence similarity of NCOR2 among different species. Supplementary figure 7. Schematic illustration showing the postulated dominant negative inhibitory effect of splice variant BQ323636.1 on the co-repressor function of NCOR2 wild type for ER� transcriptional activity. Supplementary table 1. Brest cancer cell lines used in SpliceArray profiling, and summary of the TaqMan real time qPCR validation results. Supplementary table 2. Primer and Taqman probe sequences used in qPCR validation Supplementary table 3. The correlation between BQ mRNA level, BQ/WT ratio and various clinical pathological parameters
Supplementary Methods, Figure 1 from Retinoic Acid/Alpha-Interferon Combination Inhibits Growth and Promotes Apoptosis in Mantle Cell Lymphoma through Akt-Dependent Modulation of Critical Targets
Authors: Dal Col Jessica , Mastorci Katy , Faè Damiana Antonia , Muraro Elena , Martorelli Debora , Inghirami Giorgio , Dolcetti Riccardo
Published: March 2023

PDF file - 123K
Supplementary Methods from PML-RARα and Its Phosphorylation Regulate PML Oligomerization and HIPK2 Stability
Authors: Shima Yutaka , Honma Yuki , Kitabayashi Issay
Published: March 2023

PDF - 55K, Real-time quantitative PCR data
Supplementary Figures 1-7 from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Authors: Koh Mei Yee , Lemos Robert , Liu Xiuping , Powis Garth
Published: March 2023

Supplementary Figures 1-7 from The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
Supplementary Figure 5 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Authors: Cavel Oren , Shomron Olga , Shabtay Ayelet , Vital Joseph , Trejo-Leider Leonor , Weizman Noam , Krelin Yakov , Fong Yuman , Wong Richard J. , Amit Moran , Gil Ziv
Published: March 2023

PDF file - 25K, The effect of PYP1 on the PDA cells proliferation. As revealed by XTT assay, PYP1 (2mum) had no effect on cancer cell proliferation induced by the EMPhi conditioned media.
Supplementary Figure 4 from Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor
Authors: Cavel Oren , Shomron Olga , Shabtay Ayelet , Vital Joseph , Trejo-Leider Leonor , Weizman Noam , Krelin Yakov , Fong Yuman , Wong Richard J. , Amit Moran , Gil Ziv
Published: March 2023

PDF file - 174K, Expression of the GDNF receptors GFRa1 and RET in specimens excised from patients with pancreatic ductal adenocarcinoma.(a) Low magnification (X20) immunofluorescence staining with anti-RET ab (green, Alexa 485), (b) anti-GFRa1 ab (red, Alexa 565) , and (c) overlay image with DAPI staining (blue). (d) Immunohistochemical staining of the same specimen with anti-CK19 ab (brown staining). (e) High magnification (X40) fluorescent microscope imaging performed with anti-RET (green, Alexa 485), (f) anti-GFRa1 antibodies (red, Alexa 565) and (g) DAPI (blue staining). The overlay image in (h) shows co-expression of the receptors by PDA cells.
Supplementary Figure 2 from Aptamer Identification of Brain Tumor–Initiating Cells
Authors: Kim Youngmi , Wu Qiulian , Hamerlik Petra , Hitomi Masahiro , Sloan Andrew E. , Barnett Gene H. , Weil Robert J. , Leahy Patrick , Hjelmeland Anita B. , Rich Jeremy N.
Published: March 2023

PDF file - 87K, TIC-specific aptamers preferentially bind TICs in comparison to non-TICs or U87MG cells.