bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementation Of Electronic Money In Developing Payment Transactions Through Islamic Economic Perspective
Authors: Toyyibi Abdul Majid
Published: June 2021

AbstractPurpose - By upholding the value of sharia principles economic activities. Electronic money is a financial transaction that is used by the community as a substitute for cash, and ottopay is part of it, to help become a financial intermediary with an electronic system through QR and billers.Method - The research is based on researching ottopay in its transactions by using a descriptive qualitative.Result - From the research method process used in the study resulted in the study that the implementation of ottopay in topping up by filling directly via the bank ATM or through an agent by clicking the wallet menu then top up and following the steps until the confirmation is successful and the balance is ready whenever it can be used.Implication - The existence of the Ottopay system is a support for the community to be able to think forward in the world of finance and technology, in addition, ottopay can be used as a business opportunity to provide benefits in the form of added value in the form of turnover that can be owned by merchants and can be used as additional income for the community.  Originality - The implementation of ottopay between users and publishers and users and merchants is in accordance with the rules of the DSN MUI fatwa, therefore the benefits of the ottopay application can guarantee security, easy and practical use so that people's economic turnaround is faster because it has an electronic digital system.
Post-Industrial model of Society, Education and science in Philosophical concepts of Radical Pedagogy in the context of Globalization for the Sustainable Development
Authors: Zinchenko Viktor , Krokhmal Nataliia , Horpynych Оlha , Fialko Nataliia
Published: June 2021

Critical theory of education should be based on a critical theory of society, which is conceptually analyzes the features of actually existing industrial and post-industrial societies and their relations of domination and subordination (oppression), conflict and the prospects for progressive social change and transformative practices that make projects more complete, freer life and democratic society. Criticality theory means a way of seeing and understanding, building categories, making connections, reflection and participation in practice theory, theory of withdrawal of social practice.This term contains an element of emancipation, liberation and self-determination of the oppressed and exploited masses, recognizing that people are socially excluded from the material security, education and decision-making can share vidrefleksuvaty their situation, realize that it is unauthorized again, and realize that they must organize themselves in order to change the structure of society.
Phenomenology: The Experience of HIV/AIDS Mothers in Self Disclosure to Their Children in Yogyakarta
Authors:   Universitas Jenderal Achmad Yani Yogyakarta, Hidayati Rizqi Wahyu , Rukmi Dwi Kartika
Published: June 2021

In Indonesia, there is 150,296 people with HIV AIDS. The prevention efforts is increased by awareness of the sufferer’s. They can do self- disclosure about their HIV status with the family. However, mothers feel afraid to tell their children because of the stigma. They afraid their children will leak their status to others, or become depressed. Whereas the openness of status has a positive impact on mothers, such as providing social support and increasing mother's motivation in caring of their children. The study aimed to determine the experiences of mothers with HIV in self-disclosure to children in Yogyakarta. This study used qualitative research with an interpretive phenomenological approach. Data analysis using Interpretative Phenomenology Analysis. The data collection technique used semi-structured interviews. The sampling technique used purposive sampling with the inclusion criteria: HIV women with 26-45 years and already having children. The number of participants was 5 participants in Yogyakarta. This research got 5 themes to achieve the research objectives. These themes were (1) Feeling "guilty" of children; (2) Trying to rise of life; (3) Trying to let go of the burdens life; (4) Disappointed caused by frightened; (5) Relief of being children acceptance. Self-disclosure is important because it can reduce the burden on clients of people living with HIV AIDS (PLWHA). Self-disclosure to children may increase motivation to live through the ARV treatment. Therefore, the main theme emerged was releasing one's burdens to rise in life
The Infrastructure Development Compatibility To Enhance Community Welfare
Authors: Asfar Ali , Zauhar Soesilo , Rochmah Siti , Hermawan Hermawan
Published: June 2021

This paper aims to describe and analyze the regulations, the interest of actors and the budgets compatibility between the central government, regional governments in infrastructure development of Rokan Hilir District. This research uses a descriptive approach, with qualitative research methods. The research findings show that there is no compatibility between the regulations of the central government and regional governments, therefore the regulations made by the central government cannot be carried out effectively and there are also conflicts with the wishes of local communities. The central government prioritizes the interests of the country as a whole rather than the interests of the people in the region. Infrastructure development in Rokan Hilir Regency is strongly influenced by the Executive Actor and Political Actor (Legislative). The 2012 fiscal year to 2017 indicated that the operating budget is greater than the development budget, this is happened due to the siphoning of the budget to pay the salaries of temporary workers, and other routine expenditures. The implication is that Rokan Hilir Regency unable to carry out some physical development (infrastructure).
The Effect of Ownership Structure and Leverage Towards Dividend Policy and Corporate Values
Authors: Khongrat Etty , Kusumawati Andriani , Habsyi Taber Al , Suharyono Suharyono
Published: June 2021

This research aims to examine and analyze the effect of Destination Branding on Destination Image. Testing and analyzing the effect of destination branding on destination selection and destination image on destination selection. Meeting planners who live in Jakarta and Bali destination. This research used an explanatory research with simple random sampling technique. Data collection techniques were carried out with questionnaires that distributed to 165 respondents Meeting Planners who lived in Jakarta and Bali. The data analysis used in the study is General Structured Component Analysis (GSCA). The results of this study indicate that the GSCA analysis results have shown that Destination Branding has no significant effect on the Destination Image, with a path coefficient of 0.545 with a value (p-value 0.272> 0.005). The results of the GSCA analysis have proven that Destination Branding has a significant effect on destination selection with a path coefficient of 0.266 and a p-value <0.001. The results of the GSCA analysis have shown that destination image has a significant positive effect on Destination Selection with a path coefficient of 0.299 with a p-value of <0.001.
Assessing Gombe State Citizens’ Attitude And Perception Towards Nigeria’s Cashless Policy
Authors: Bachama Yusufu Nigel , Bello Matthew Funsho
Published: June 2021

The Central Bank of Nigeria (CBN) introduced the cashless policy in 2011, which eventually took effect in 2012. The aim of the policy amongst others is to reduce the amount of physical cash circulating in the economy and encouraging more electronic-based transactions. The objective of this study is to review the CBN cashless policy in Gombe State and assess peoples’ behavior and attitudes towards the policy in the State since its inception. Questionnaires were administered on 300 bank customers across the 11 Local Government Areas (LGAs) of the State. The findings revealed that 65% of respondents do not know what the cashless policy is all about, 80% are happy with the introduction of cash-lite (Cashless) points such as Automated Teller Machines, Point of Sales, and Internet Banking etc. As an interim verdict, 25% of the respondents believe that the cashless policy is necessary, 24% believe that the CBN approach to its implementation is the best and 43% believe that the policy will succeed. The study recommends that more banks’ branches and cash-lite channels need to be established especially in other LGAs; there is also the need to consolidate in infrastructural development; and financial literacy for all.
The Classics at World’s End.
Authors: Maas Tycho
Published: June 2021

The Dutchman Johannes Willem van Grevenbroek (1644-circa 1726) was secretary of the Dutch East India Company’s Council of Policy at the Cape from 1684 to 1694. In the years that had passed since Jan van Riebeeck’s landing at the Cape in 1652, marking the first permanent European settlement in modern-day South Africa, regular expeditions had been launched into its hinterland. A year after his retirement from VOC service, Grevenbroek wrote a letter in Latin about the Cape’s native inhabitants: Elegans et accurata gentis Africanae circa Promontorium Capitis Bonae Spei vulgo Hottentotten Nuncupatae Descriptio Epistolaris (An Elegant and Accurate Account of the African Race Living Round the Cape of Good Hope, Commonly Called Hottentots). In this paper, I consider Grevenbroek’s engagement with ancient (Greek and Roman) antiquity in his framing of the Khoi. Ancient times had left early modern Europe with an authoritative literature on the world’s geography and history, descriptions about its then-known people, and suppositions about the ways of life of its many un-known people in yet to be discovered realms. In his letter, Grevenbroek returns to the Classical sources to meaningfully recapture the Cape native people and thus renegotiate the popular contemporary European image about them.
Construir tamaños de muestra a partir de datos del Tercer Censo Nacional Agropecuario (3er CNA): una alternativa ante la ausencia de marco muestral
Authors: Romero Barrera Yajaira , Ávila Cárdenas Jacqueline , Suárez Villota Pedro David , Fuentes Benítez Juan Carlos
Published: June 2021

Una de las principales limitantes en la realización de estudios socioeconómicos por encuestas en el sector agropecuario es la ausencia de marcos muestrales actualizados y suficiente información con respaldo estadístico. El primer reto por superar es la definición de un diseño muestral que permita elegir una muestra representativa. En este libro se presentan conceptos generales sobre métodos de muestreo, una propuesta metodológica para el uso de los datos del Tercer Censo Nacional Agropecuario (CNA), así como un ejemplo de aplicación para definir el marco muestral y la muestra, los cuales emplean los registros de las unidades productoras agropecuarias (UPA). A su vez, está dirigida a personas y entidades que, en sus dinámicas productivas, de mercado y política pública requieren realizar estudios por encuestas y recolectar y analizar datos para la toma de decisiones, convirtiéndose así en una guía práctica para la correcta aplicación de metodologías de muestreo en el sector agropecuario del país.
Using Emerging Telehealth Technology as a Future Model in Vietnam During the COVID-19 Pandemic: Practical Experience From Phutho General Hospital
Authors: Nguyen Ngoc Huy , Nguyen An Quang , Ha Van Thi Bich , Duong Phuong Xuan , Nguyen Thong Van
Published: June 2021

Telehealth has emerged as a model of modern technology for health care services in Vietnam during the COVID-19 pandemic. To actively prevent the outbreak of COVID-19 by using a national digital transformation program, the Vietnamese Ministry of Health launched project 2628/Quyet dinh-Bo y te, which approved a scheme for remote medical examinations and treatments for 2020 to 2025. The project aims to connect 1000 hospitals to strengthen the quality of medical services by using the expertise of central hospitals to support rural areas via provincial hospitals. Phutho General Hospital (PGH) is one of leading provincial hospitals that participated in and applied the early telehealth systems in Vietnam. By using telehealth systems, PGH can offer valuable support to doctors’ activities by streamlining and facilitating their work. Telehealth was demonstrated to be feasible, acceptable, and effective at PGH in Vietnam, and it resulted in considerable improvements in health care outcomes. The COVID-19 pandemic has facilitated the acceleration and enhancement of telehealth in Vietnam. The success of telehealth in Phutho may be a useful reference for other parts of the world. However, this telehealth system focuses on the connectivity among doctors rather than the connectivity between doctors and patients, which is an area that needs further assessment.
Revealing Public Opinion Towards COVID-19 Vaccines With Twitter Data in the United States: Spatiotemporal Perspective (Preprint)
Authors: Hu Tao , Wang Siqin , Luo Wei , Zhang Mengxi , Huang Xiao , Yan Yingwei , Liu Regina , Ly Kelly , Kacker Viraj , She Bing , Li Zhenlong
Published: June 2021

BACKGROUND

The COVID-19 pandemic has imposed a large, initially uncontrollable, public health crisis both in the United States and across the world, with experts looking to vaccines as the ultimate mechanism of defense. The development and deployment of COVID-19 vaccines have been rapidly advancing via global efforts. Hence, it is crucial for governments, public health officials, and policy makers to understand public attitudes and opinions towards vaccines, such that effective interventions and educational campaigns can be designed to promote vaccine acceptance.

OBJECTIVE

The aim of this study was to investigate public opinion and perception on COVID-19 vaccines in the United States. We investigated the spatiotemporal trends of public sentiment and emotion towards COVID-19 vaccines and analyzed how such trends relate to popular topics found on Twitter.

METHODS

We collected over 300,000 geotagged tweets in the United States from March 1, 2020 to February 28, 2021. We examined the spatiotemporal patterns of public sentiment and emotion over time at both national and state scales and identified 3 phases along the pandemic timeline with sharp changes in public sentiment and emotion. Using sentiment analysis, emotion analysis (with cloud mapping of keywords), and topic modeling, we further identified 11 key events and major topics as the potential drivers to such changes.

RESULTS

An increasing trend in positive sentiment in conjunction with a decrease in negative sentiment were generally observed in most states, reflecting the rising confidence and anticipation of the public towards vaccines. The overall tendency of the 8 types of emotion implies that the public trusts and anticipates the vaccine. This is accompanied by a mixture of fear, sadness, and anger. Critical social or international events or announcements by political leaders and authorities may have potential impacts on public opinion towards vaccines. These factors help identify underlying themes and validate insights from the analysis.

CONCLUSIONS

The analyses of near real-time social media big data benefit public health authorities by enabling them to monitor public attitudes and opinions towards vaccine-related information in a geo-aware manner, address the concerns of vaccine skeptics, and promote the confidence that individuals within a certain region or community have towards vaccines.
PHYSICAL AND CHEMICAL CHARACTERISTIC OF YOUNG COCONUT LEAVES (Cocos nucifera L.) AS TRADITIONAL PACKAGING
Authors: Hasanah Uswatun , Dewi Edlina Putri Sukma , Santoso Umar , Supriyadi Supriyadi
Published: June 2021

Traditional food is usually packed with natural packaging materials such as young coconut leaves (janur), but a little scientific information is available related to the packaging material. This study aimed to examine the physical and chemical characteristics of fresh and steamed janur (30 minutes steaming at 100 0 C). The physical and chemical properties of janur were expected to be the basis for the development of janur as an environmentally friendly packaging material. The results showed that fresh and steamed janur color was greenish-yellow and brownish-yellow. The fresh and steamed janur had a tensile strength 19.19 MPa and 30.62 MPa; water content 73.54% and 69.57%; and fat content 1.85% and 0.54%, respectively. After steaming, the microstructure of the cells became finer and irregular. The dominant fatty acid in fresh janur and steamed janur was palmitic acid (24.27%), and palmitoleic acid (38.56%), respectively. The treatment of steaming of janur influenced the physical and chemical characteristics of packaging materials.
Sensory Analysis, Caffeine, Chlorogenic Acid and Non-Volatile Taste Compounds of Arabica Coffee (Coffea arabica) Fermented with Sugar Addition for Brew Taste
Authors: Santosa Kresna Mulya , Supriyadi Supriyadi , Anggrahini Sri , Rahmadian Yudi
Published: June 2021

Arabica coffee is the most popular variety of coffee among the people because it has a more complex flavor than other coffee varieties. This study aims to determine sensory properties and non-volatile components in Arabica coffee fermented with sugar addition. The sensory assessment showed that the best cupping score was the samples fermented with the addition of 0.55% fructose with a total score of 85.25 compared to honey (H) and Fullwash (FW) samples. Fermentation with the addition of 0.55% fructose could produce better coffee compared to samples (H) and (FW). Fermentation with the sugar addition of 0.55% could affect non-volatile components such as soluble sugars, organic acids, amino acids, caffeine, and chlorogenic acid. The content of chlorogenic acid and caffeine analysed by HPLC was found relatively stable in green and roasted beans. Amino acids analysed by LCMS showed glutamate was the highest amino acid in all samples and were supposed to have a role in Maillard reaction contributing to coffee flavor. In conclusion, fermentation with the addition of 0.55% sugar in coffee processing could generally enhance the coffee flavor for brew taste with its potential as functional drink.
Intervenciones psicológicas en cuidadores primarios de pacientes con trasplante de células hematopoyéticas: Revisión descriptiva
Authors: Brenes-Mesa L. , Valero-Saldaña L.M. , Acosta-Maldonado B. , Rodríguez-Aguilar M.R. , Aguilar-Ponce J.L. , Rivera-Fong L.
Published: June 2021

Introducción: El ser cuidador primario informal de un paciente con indicación médica de trasplante de células progenitoras hematopoyéticas puede tener consecuencias negativas en su salud mental y calidad de vida.

Objetivo: Describir las intervenciones psicológicas disponibles para el cuidador primario de pacientes sometidos a trasplante de células hematopoyéticas.

Metodología: Se realizó una búsqueda sistematizada de los últimos 10 años con los términos MeSH: psychotherapy AND caregive AND stem cell transplantation en las principales bases de datos médicas y de psicología, para su análisis se empleó la estrategia: Problema, Intervención, Comparación y Outcomes (PICO).

Resultados: Se identificaron 122 artículos, de ellos diez cumplieron los criterios de inclusión. Las intervenciones provenían de profesionales de enfermería o trabajo social; el 50% incluyó diadas (paciente y cuidador primario), mostraron una tendencia de duración corta, enfocada al periodo posterior al trasplante. Se basan en el entrenamiento en solución de problemas, manejo de estrés, atención plena y expresión emocional. Las intervenciones lograron la disminución de la depresión, ansiedad y estrés en el cuidador; pero no alcanzaron permanencia en la significancia estadística de dichos restablecimientos.

Discusión: De acuerdo con lo observado en las publicaciones y por su impacto positivo en la salud mental, se recomienda la implementación de intervenciones psicológicas en cuidadores de pacientes con trasplante de células progenitoras hematopoyéticas.

Conclusión: El apoyo psicológico brindado al cuidador generalmente es de profesionales de la salud que no pertenecen al área de la psicología, con resultados clínicos favorables en las etapas más críticas de su estado mental.
Relevancia de los intangibles para la valoración de las acciones de las empresas en el mercado: evidencias desde el contexto argentino
Authors: Ficco Cecilia Rita , Werbin Eliana , Díaz Margarita , Prieto Moreno María Begoña
Published: June 2021

El objetivo de este trabajo es analizar la influencia de la información sobre activos intangibles y capital intelectual en la valoración de las acciones de las empresas que cotizan en el MCA, donde no se han constatado trabajos publicados de esta naturaleza. El análisis se realiza aplicando un modelo de construcción propia, basado en Ohlson (1995). Los datos corresponden al período 2009-2018 y han sido recolectados directamente de fuentes originales. Se obtuvieron de los estados financieros anuales consolidados de las empresas y de los registros de negociación de sus acciones en el Mercado de Valores de Buenos Aires. Los resultados revelan que los activos intangibles identificables, el capital humano y el estructural poseen relevancia valorativa, lo que contribuye a acrecentar la evidencia existente en torno al papel de los intangibles en la valoración externa de las empresas, la cual es particularmente limitada para mercados poco desarrollados.
Financial prudential behavior and economic growth
Authors: Rivas Aceves Salvador , Dávila Aragón Griselda
Published: June 2021

The 2008 global financial crisis showed not only that there is a link between real economy and financial markets, but also that financial stability is necessary for investment, innovation and of course economic growth. Regarding the link between real and financial sectors, several studies long before the 2008 financial crisis revealed positive impacts from financial sector on real economy, basically because a solid financial system promote physic and human capital accumulation, see Banerjee and Newman (1993) Galor and Zeira (1993), Aghion and Bolton (1997), Piketty (1997), Levine (1997), Levine and Zervos (1998), Rajan and Zingales (1998). When considering well-developed financial markets as economic growth promoters the researches of Levine (2005), Aghion et al. (2005) and Acemoglu et al. (2006) proved that financial develop indeed accelerates economic growth.
Tipo de cambio y crecimiento económico en México
Authors: Cerezo García Verónica
Published: June 2021

Durante 2001-2018 la tasa de inflación se mantuvo baja y estable en México y el crecimiento económico registró una tasa promedio anual de 2.5%, a pesar del constante aumento en las exportaciones. El notable estancamiento de la economía mexicana y de otras economías de América Latina, indujo a algunos autores a argumentar que el origen del lento crecimiento estriba en que los bancos centrales aprecian el tipo de cambio para anclar la inflación. Para acelerar el crecimiento económico proponen
un tipo de cambio competitivo. Para comprobar esta hipótesis elaboramos un modelo de regresión con rupturas para calcular el tipo de cambio de equilibrio; a partir de esto estimamos un modelo NADRL para conocer las desviaciones (apreciaciones y depreciaciones) con respecto al tipo de cambio de equilibrio. Los resultados muestran que durante 1993-2018 un tipo de cambio estable y competitivo per se no acelera el crecimiento económico.
Efecto de tratamiento con plasma frío en puré de jaca: descontaminación de esporas de Aspergillus niger y atributos de calidad
Authors: Casas-Junco Paloma Patricia , Solís-Pacheco Josué Raymundo , Ragazzo-Sánchez Juan Arturo , Aguilar-Uscanga Blanca Rosa , Calderón-Santoyo Montserrat
Published: June 2021

El puré de jaca se contaminó artificialmente con esporas de Aspergillus niger para tratarlo con plasma frío (30 W, 1.5 L / min de Helio, en un lapso de 0 a 16 min, posteriormente las muestras se almacenaron a 25 ºC durante 60 días en los que no hubo crecimiento, ni cambios en los sólidos solubles totales, color o aw,sin diferencias significativas en los perfiles aromáticos y tampoco en las muestras no tratadas, en el pH y la acidez total los cambios fueron mínimos. Se logró una reducción de 4 log (UFC / g) en las esporas de Aspergillus niger, coliformes y bacterias mesófilas aerobias después de 8 min de tratamiento a 30 W y 850 V con gas Helio. No se observó alteración en las propiedades sensoriales del puré de jaca tratado. El plasma atmosférico frío es una tecnología no térmica prometedora para su uso en productos de frutas procesadas.
La importancia del financiamiento sobre la producción científica en México
Authors: Ugarte Pineda Eva , Parra Huerta Gilberto
Published: June 2021

En esta investigación se estudia el financiamiento de la investigación básica en México en el periodo 2009- 2019. El análisis utiliza datos de Web of Science y se enfoca en el Science Citation Index Expanded. Ponemos especial atención en el impacto que tienen los recursos del Conacyt sobre la producción académica. Los resultados revelan que 75.65 % de las publicaciones del periodo recibieron financiación. El Conacyt aparece como institución financiadora en 46.05 % de los documentos. Otro aspecto que estudiamos es la difusión de la investigación científica. Identificamos que 68.13 % de los documentos que recibieron apoyo económico del Conacyt se publicaron en revistas de acceso restringido, es decir, están detrás de muros de pago.
Lectura crítica del relato audiovisual como fuente de información en el filme Taxi Driver
Authors: Valhondo-Crego José Luis , Vivas Moreno Agustín
Published: June 2021

La presente investigación aborda, desde la metodología de la lectura crítica, el filme de ficción como documento audiovisual. Parte de la hipótesis de cómo el relato audiovisual es capaz de representar, mediante su lectura reflexiva, el espíritu de una época. Ciertos fenómenos sociales, como la soledad, pueden entenderse de un modo más profundo a partir de la mirada subjetiva de un autor y su obra ficticia. Desde décadas recientes, vivir solo ha dejado de ser algo estadísticamente marginal o socialmente extraño. Por una parte, se ha convertido en una oportunidad vital para alcanzar objetivos personales; por la otra, en un problema social que implica a un número cada vez mayor de individuos. A través de un ensayo de lectura del relato audiovisual, este artículo examina cómo se hace sensible al espectador la soledad a través del caso de estudio del filme Taxi Driver, con guion de Paul Schrader y dirección de Martin Scorsese. Se examina el modo en que se encarna esa soledad a través de la puesta en escena de un guion en el que la escritura de un diario personal es clave para racionalizar las imágenes documentales de una época.
Pectin Degradation in Fruit Juices by Pectinase from Meyerozyma sp. VITPCT75 Isolated from Phyllanthus emblica
Authors: Meena B. , Sowmeya V.G. , Praveen Archa B. , Swetha A. , Chandra D. Naga Sarath , Kavitha M.
Published: June 2021

This study aimed to identify and characterize a pectinase-producing novel yeast from the fermented juice of Phyllanthus emblica and apply the enzyme for fruit juice clarification. Among the five pectinase-producing yeasts, isolate-1 exhibited the highest pectinase activity and was further used in this study. Based on morphological, physiological, and 18SrRNAanalyses, isolate-1 was recognized as a new strain sharing 99% sequence homology with other Meyerozyma strains and was thus designated as Meyerozyma sp. VITPCT75. The strain produced pectinase optimally at a temperature and pH of 25oC and 7, respectively. Maximum pectinase production was observed after 4-days incubation. The enzyme exhibited optimum activity at the temperature of 25 °C and pH 7.0. The enzyme was more stable at a temperature and pH of 20 °C and 7, respectively. Storage stability studies revealed that the enzyme was stable at -20 °C. The cell-free supernatant was partially purified using ammonium sulfate and solvent precipitation. Acetone at a concentration of 20% assured an adequate partial purification. The molecular weight of pectinase was determined as 6 kDa. The enzymatic metal ion preference-related studies revealed that Ca²z, Kz, Cu²z, Fe²z, and Ba²z ions enhanced, Ni²z ions moderately inhibited, and Mn²z ions intensely inhibited the enzymatic activity. Neither Na+ and Mg2+ ions nor EDTA affected the enzyme activity. When subjected to fruit juice clarification, the enzyme significantly reduced the viscosity of the juice.
The Identification of the SARS-CoV-2 Whole Genome: Nine Cases Among Patients in Banten Province, Indonesia
Authors: Adhiyanto Chris , Hendarmin Laifa A. , Suwarsono Erike A. , Harriyati Zeti , Suryani  , Puspitaningrum Rini , Nurjadi Dennis
Published: June 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of virus that causes coronavirus disease 2019 (COVID-19), the respiratory illness responsible for the current pandemic. Viral genome sequencing has been widely applied during outbreaks to study the relatedness of this virus to other viruses, its transmission mode, pace, evolution and geographical spread, and also its adaptation to human hosts. To date, more than 90,000 SARS-CoV-2 genome sequences have been uploaded to the GISAID database. The availability of sequencing data along with clinical and geographical data may be useful for epidemiological investigations. In this study, we aimed to analyse the genetic background of SARS-CoV-2 from patients in Indonesia by whole genome sequencing. We examined nine samples from COVID-19 patients with RT-PCR cycle threshold (Ct) of less than 25 using ARTIC Network protocols for Oxford Nanopore’s Gridi On sequencer. The analytical methods were based on the ARTIC multiplex PCR sequencing protocol for COVID-19. In this study, we found that several genetic variants within the nine COVID-19 patient samples. We identified a mutation at position 614 P323L mutation in the ORF1ab gene often found in our severe patient samples. The number of SNPs and their location within the SARS-CoV-2 genome seems to vary. This diversity might be responsible for the virulence of the virus and its clinical manifestation.
Evaluating Desert Actinomycetes for Enzyme and Antibacterial Production
Authors: Alghamdi Abdulrahman A.M. , Abdelmoneim Tamer S. , Kadasa Naif , Almulaiky Yaaser Q.
Published: June 2021

A total of 13 Actinomycete strains were isolated from 70 soil samples collected from five locations across the Jeddah Province, while the other two locations located in Baljurashi province of Saudi Arabia. All 13 isolates were purified and subjected to enzymatic screening and antibacterial assays. The results indicated that two of these isolates (AC45 and AC69) produced both enzymes and exerted some antibacterial activity. Isolate AC45 produced more amylase and polygalacturonase (697.8 and 1498.59 units/ml, respectively) than isolate AC69; however, AC69 secreted more lipase than AC45 (6957 and 22127 unit/ml, respectively). Furthermore, both AC45 and AC69 exhibited good antibacterial activity against Staphylococcus aureus, Staphylococcus epidermidis, and Bacillus subtilis. The two isolates were identified using their 16S rRNA sequences, and the results suggest that isolate AC45 shares 99.71% similarity with Streptomyces lavenduligriseus and isolate AC69 shares 99% similarity with Streptomyces sp.
PERTANGGUNGJAWABAN HUKUM DOKTER PROGRAM INTERNSIP DALAM PELAYANAN KESEHATAN TERHADAP PASIEN
Authors: Irwanto Ade , Razy Fakhruddin
Published: June 2021

.  Suppose there is a problem related to the loss incurred to the patient when the doctor of the Internship program does not meet the established educational standards. In that case, health services will be exposed to a greater risk of civil liability if they ignore internal arrangements related to internal physicians. The risk of joint civil litigation will be very burdensome for interns and hospitals if hospital leaders issue wrong clinical assignments. Hospitals need to be aware that material and substance cannot be compared between hospitals and hospitals. Each hospital should ask their medical committee to arrange bylaws related to implementing the profession of interns in their respective hospitals. The approach used in this study is the method of the Legislative Approach (Statue Uproach), Conceptual Approach, and Sociological Approaches. By law anyone who causes or incurs a loss to another person is required to account for any such loss. Likewise, doctors, as health workers who have provided health services (medical measures) to patients, if the doctor incurs losses with these services, are obliged to provide accountability. The responsibility of doctors who commit malpractice can be punched in 3 (three) aspects: civil, criminal, and administrative matters.
Conformidade normativa dos estabelecimentos de educação infantil privados de Gravataí, RS
Authors:   Secretaria Municipal de Saúde de Gravataí, RS, Brasil, Cavalheiro Teixeira Suelen , Silva da Silva Patrícia ,   Secretaria Municipal de Saúde de Gravataí, RS, Brasil, Bordin Ronaldo ,   Programa de Pós-Graduação em Administração, Universidade Federal do Rio Grande do Sul
Published: June 2021

Introduction: In the state of Rio Grande do Sul, State Ordinance number 172/2005 establishes the technical regulation for licensing of preschool education (0-6 years old), including: aspects related to hygiene, conservation and organization of environments, furniture and utensils; minimum required professionals present in the staff; the need for an approved architectural project in municipal sanitary surveillance and operating authorization issued by the State or Municipal Board of Education, among others. Objective: To describe the regulatory compliance of private establishments for early childhood education in the city of Gravataí (RS), from January 2018 to April 2019. Method: The documents required to regularize the establishments with the Health Surveillance and the Municipal Department of Education were used as data source. Results: Of the 69 establishments registered in the period, 4 were banned by the Sanitary Surveillance, 5 closed its activities and 60 remained active. Among the 60 active establishments, 8 had a current sanitary permit, 20 had an architectural project approved by the municipal sanitary surveillance, 36 had minimum documentation and approval by the Gravataí Municipal Education Council and 13 relied on properly qualified teachers. Conclusions: Most establishments did not meet the requirements of the Ordinance that regulates their licensing.
Perfil da estrutura, equipe e trabalho da Vigilância Sanitária na VI Região de Saúde de Pernambuco
Authors:   Escola de Governo em Saúde Pública de Pernambuco (ESPPE), Arcoverde, PE, Brasil, Kelly de Souza Cabral Laryssa , Emanuel da Silva Melo Willians ,   VI Gerência Regional de Saúde (VI Geres), Arcoverde, PE, Brasil, Maria Silva Rodrigues Rosângela ,   VI Gerência Regional de Saúde (VI Geres), Arcoverde, PE, Brasil / Agência Pernambucana de Vigilância Sanitária (Apevisa), Arcoverde, PE, Brasil
Published: June 2021

Introdução: A descentralização e a municipalização da Vigilância Sanitária são preceitos do sistema único de saúde, pois sabe-se que as condições de gestão que os municípios vivenciam podem interferir nas ações a serem realizadas. Objetivo: Descrever o perfil da Vigilância Sanitária da VI Região de Saúde de Pernambuco. Método: Trata-se de um estudo com abordagem quantitativa descritiva, com dados secundários. Os dados fazem parte de um questionário elaborado e aplicado pelo departamento de Vigilância em Saúde da VI Gerência Regional de Saúde. Os dados foram analisados por estatística descritiva e apresentados em tabela. Resultados: Todos os municípios possuem coordenador, sendo a maioria efetivos e com curso superior da área de saúde. Estão com a equipe incompleta, contudo grande parte possui capacitação no Curso Básico de Vigilância Sanitária. Realizam reunião de equipe mensal, planejamento anual de ações e também avaliação de indicadores próprios. Não participam dos gastos do Programa de Qualificação das Ações de Vigilância em Saúde. Trabalham com sistema de vigilância sanitária, emitem licença de funcionamento, não trabalham com código sanitário e suas principais atividades são as inspeções. Possuem espaço físico adequado, com os materiais necessários e a maior dificuldade é o transporte. Conclusões: Entender o perfil da Visa municipal é essencial para que haja crescimento e eficácia na gestão. A Visa ainda passa por situações desfavoráveis devido a descentralização, mas as informações evidenciadas no estudo demonstram um avanço.
Amiúdes cambiantes | Frequent changes
Authors: Cavalcante Guilherme Silva
Published: June 2021

O ensaio Amiúdes Cambiantes é um compilado de fotografias que escrutinam este sintoma, oferecendo seu ângulo para salientar as condições que pairam sobre o sujeito contemporâneo. As fotografias foram tiradas entre os anos de 2018 a 2020, nos estados de Mato Grosso do Sul, Rio Grande do Sul e São Paulo.
Smudging boundaries - territories
Authors: Vastavikta Bhagat  , moomal shekhawat
Published: June 2021

We at SEA believe that the pandemic has a granularity of meta, non-linear narratives that become useful in making sense of the relational complexities of the pandemic and society. Thus, we set out to collect stories of fears, joys, agilities, fragilities, friendships, networks, collectives, home, work, infrastructures, entrepreneurship, privileges, marginalizations, migrations, desperation, gender, equity, etc. The glossary as a method became useful to reflect on this granularity of experiences and account for slippages during these times. These spatio-temporal stories, when read together or as individual instances produce a new sense of the emergent contemporary. This framework also allows us to speculate on the kind of world we will inhabit once the storm has passed.

We draw on multiple readings to bring out the nuances and patterns of social life produced in a pandemic. This we hope would allow us to collectively reflect on the restructured ideas of the self, the collective, society, space, and time.

On smudging of territorial spatialities, forming new peer networks, post institution and connecting with the world.
Acute effect of add-on therapy with tofogliflozin, a sodium glucose co‐transporter 2 inhibitor, on 24-hour glucose profile and glycemic variability evaluated by continuous glucose monitoring in patients with type 2 diabetes receiving dipeptidyl peptidase-4 inhibitors.
Authors: Aso Yoshimasa , Iijima Toshie , Hosonuma Soichiro , Kurai Hidetaka , Kanitani Hayato , Sakurai Shintaro , Tomaru Takuya , Jojima Teruo , Usui Isao
Published: June 2021

Aim: To investigate acute effects of add-on therapy with the sodium
glucose co‐transporter 2 inhibitor tofogliflozin to dipeptidyl peptidase
(DPP)-4 inhibitors on 24-hour glucose profile and glycemic variability
evaluated by continuous glucose monitoring (CGM) in patients with type 2
diabetes. Patients and methods: We studied 17 patients with type 2
diabetes who were hospitalized for glycemic control. CGM was performed
for 7 consecutive days in the last week of hospitalization.
Tofogliflozin 20 mg/day was started on day 4 after initiating CGM and
was administered to 10 patients receiving DPP-4 inhibitors and 7
patients not receiving DPP-4 inhibitors. We compared several CGM
parameters between day 2 to 3 (ie, before treatment with tofogliflozin)
and day 5 to 6 (ie, after starting treatment with tofogliflozin).
Results: After starting treatment with tofogliflozin, mean 24-hour
glucose and postprandial glucose after each meal were significantly
decreased in both groups of patients. Time in range (ie, at a glucose
level of 70-180 mg/dL) was significantly increased in both groups. The
standard deviation of 24-hour glucose and mean amplitude of glycemic
excursions, 2 indexes of glycemic variability, were significantly
decreased in patients receiving DPP-4 inhibitors but were unchanged in
those not receiving these drugs. Conclusions: Add-on therapy with
tofogliflozin to DPP-4 inhibitors acutely reduces 24-hour glucose levels
and improves glycemic variability in patients with type 2 diabetes.
External validation of the T.O.HO. score and derivation of the modified T.O.HO. score for predicting stone-free status after flexible ureteroscopy in ureteral and renal stones
Authors: Polat Salih , Danacioglu Yavuz Onur , Soytas Mustafa , Yarımoğlu Serkan , Koras Omer , Fakir Ali Emre , Seker Kamil Gokhan , Degirmenci Tansu
Published: June 2021

Abstract The T.O.HO. scoring system was developed to predict stone-free
status after flexible ureterenoscopy (fURS) lithotripsy applied for
ureter and renal stones. This study aimed to perform the external
validation of the T.O.HO. score in the Turkish population and propose a
modification for this system. Material Methods Patients who underwent
fURS for kidney and ureteral stones between January 2017 and January
2020 were retrospectively analyzed. The patient and stone
characteristics and perioperative findings were noted. The T.O.HO. score
was externally validated and compared with the STONE score. Stone-free
parameters were evaluated with the multivariate analysis. Based on the
results of this analysis, the T.O.HO. score was modified and internally
validated. Results A total of 621 patients were included in the study.
The stone-free rate was determined as 79.8% (496/621) after fURS. The
regression analysis showed that stone area had better predictive power
than stone diameter (p=0.025). Lower pole (reference), middle pole
[odds ratio (OR)=0.492 p=0.016] and middle ureteral (OR=0.227,
p=0.024) localizations, stone density (OR=1.001, p<0.001), and
stone volume (OR = 1.008, p <0.001) were determined as
independent predictive markers for stone-free status. Based on the
effect size of the stone surface area in the nomogram, stone volume was
divided into five categories, at 1-point intervals. The AUC values of
the T.O.HO., STONE, and modified T.O.HO. score in predicting stone-free
status were calculated as 0.758, 0.634, and 0.821, respectively. The
modified T.O.HO. created by adding stone volume was statistically
significantly superior to the original version (ROC curve comparison, p
< 0.001). Conclusion The T.O.HO. score effectively predicted
stone-free status after fURS. However, Modified T.O.HO. SS showed the
best predictive performance compared with original T.O.HO. SS.
Non Recurrent Laryngeal Nerve and Arteria Lusoria: Rare and Little Known Association
Authors: Mediouni Azza , Sayedi Hela , chahed houda , Besbes Ghazi
Published: June 2021

Non recurrent laryngeal nerve (NRLN) is an extremely rare entity
constantly associated with an aberrant right subclavian artery also
called arteria lusoria. Knowing this association can help predicting a
NRLN preoperatively and thus to prevent its injury. We present two
patients in whome this association was proven.
Impact of Off-pump and On-pump Coronary Artery Bypass Grafting on In-hospital Mortality and Mid-term Survival of Octogenarians
Authors: Attia Rizwan , Panoulas Vasileios , Marczin Nandor , Bhudia Sunil , Raja Shahzad
Published: June 2021

Background: Octogenarians are being increasingly referred for coronary
artery bypass grafting (CABG). However, there is a paucity of studies
reporting impact of choice of surgical revascularization strategy on
in-hospital mortality and mid-term survival of octogenarians. We
evaluated our institutional experience to determine the impact of
off-pump and on-pump CABG on in-hospital mortality and mid-term survival
of octogenarians. Methods: We retrospectively analysed prospectively
collected data from the Patients Analysis and Tracking System database
(Dendrite Clinical Systems, Oxford, UK) for all isolated first-time CABG
procedures with at least 2 grafts performed at our institution from
January 2000 to September 2017. Over the study period, 566 octogenarians
underwent either off-pump (N = 374) or on-pump CABG (N = 192).
Short-term outcomes including in-hospital mortality as well as mid-term
survival was compared for the two groups. Results: The two groups had
similar preoperative demographics and mean number of distal anastomoses
(off-pump: 2.7 ± 0.6 [median 3] vs on-pump: 2.7 ± 0.3 [median
3]; P=0.6). However, more bilateral internal mammary artery grafts
were performed in the off-pump cohort compared to on-pump cohort (117
[31.3%] vs 22 [11.5%]; P <0.001). In-hospital
mortality for the entire cohort was 5.7% with significantly fewer
deaths in the off-pump cohort (4.3% vs 8.3%; P=0.04). The remaining
in-hospital outcomes were similar. Kaplan-Meier survival at 1 year
(89.7% vs 82.9%; P=0.048) and 5 year (71.1% vs 61.3%; P=0.038) was
significantly better for the off-pump cohort. Conclusion: Octogenarians
experience lower in-hospital mortality and improved mid-term survival
after off-pump CABG compared to on-pump CABG.
A screening tool to identify risk for bronchiectasis progression in children with cystic fibrosis
Authors: Caudri Daan , Turkovic Lidija , Klerk Nicholas de , Rosenow Tim , Murray Conor , Steyerberg Ewout , Ranganathan Sarath , Sly Peter , Stick Stephen , Breuer Oded
Published: June 2021

Background: The marked heterogeneity in CF disease complicates selection
of those most likely to benefit from existing or emergent treatments.
Objective: We aimed to predict progression of bronchiectasis in
preschool children with CF. Methods: Using data collected up to three
years of age, in the Australian Respiratory Early Surveillance Team for
CF (AREST CF) cohort study, clinical information, chest computed
tomography (CT) scores and biomarkers from bronchoalveolar lavage were
assessed in a multivariable linear regression model as predictors for CT
bronchiectasis at age 5-6. Results: Follow-up at 5-6 years was available
in 171 children. Bronchiectasis prevalence at 5-6 was 134/171 (78%) and
median bronchiectasis score 3 (range 0-12). The internally validated
multivariate model retained eight independent predictors accounting for
37% (Adjusted R2) of the variance in bronchiectasis score. The
strongest predictors of future bronchiectasis were: pancreatic
insufficiency, repeated intravenous treatment courses, recurrent lower
respiratory infections in the first 3 years of life and lower airway
inflammation. Dichotomizing the resulting prediction score at a
bronchiectasis score of above the median resulted in a diagnostic odds
ratio of 13 (95% CI 6.3-27) with a positive and negative predictive
values of 80% (95%CI 72%-86%) and 77% (95% CI 69%-83%)
respectively. Conclusion: Early assessment of bronchiectasis risk in
children with CF is feasible with reasonable precision at a group level,
which can assist in high-risk patient selection for interventional
trials. The unexplained variability in disease progression at individual
patient level remains high, limiting the use of this model as a clinical
prediction tool.