bluuebunny/crossref_metadata_2025 huggingface dataset:
Unusual case of Marchiafava-Bignami disease presenting as axial hypotonia
Authors: Miletic-Drakulic Svetlana , Jevdjic Jasna , Aleksic Dejan , Toncev Gordana
Published: September 2017

Introduction. Marchiafava-Bignami disease is a rare disorder mostly associated with chronic heavy alcohol consumption that results in progressive demyelination and necrosis of the corpus callosum. Case report. We reported a 35-year-old woman with a history of alcohol consumption and malnutrition. Neurological examination revealed axial hypotonia, dysarthric speech and lack of motor coordination. The brain multislice computed tomography imaging demonstrated hypodense lesion of the corpus callosum. On the basis of her history, clinical features and imaging studies, the diagnosis of an acute form of Marchiava-Bignami disease was made. Definite diagnosis was confirmed at autopsy. Conclusion. Marchiafava-Bignami disease is of a medical emergency and early recognition and early aggressive treatment are critical for a good clinical outcome. To our knowledge, this is the first case of Marchiafava-Bignami disease presented with axial hypotonia.
Morphological characteristics of the myocardial bridges in the level of the anterior interventricular branch of a human fetal heart
Authors: Cukuranovic Ognjen , Mandaric Vladimir , Pantovic Vukica , Mihailovic Dragan , Jovanovic Ivan , Veljkovic-Cukuranovic Aleksandra , Cukuranovic-Kokoris Jovana , Vasovic Ljiljana
Published: September 2017

Background/Aim. Myocardial bridges (MB) are narrower or wider fascicles of the atrial or ventricular muscle fibres which form a ?bridge? either across the main trunks of coronary arteries or their major subepicardial branches. The aim of this research was to determine and present the exact frequency, morphological, morphometric and histological characteristics of the MB in the level of anterior interventricular branch (AIB) in human fetal hearts. Methods. The study was performed on 63 human fetal hearts. Images of the analyzed hearts were captured with a digital camera and afterwards morphometrically evaluated with ImageJ. Characteristic cases of the MB were dissected, sampled and further routinely processed for the subsequent histological analysis. Finally, the obtained morphometric data were statistically analyzed. Results. The presence of the MB on the AIB was proven histologically and under the magnifying glass. Myocardial bridges were found in 53.97% of the hearts. The percentage of the hearts with only one MB detected on AIB 88.24% was significantly higher than the percentage of the hearts with two MBs on the AIB (11.76%) (p < 0.001). Conclusion. We suggest that the MBs are just one anatomical variation of the fetal period as well as of adulthood.
The application of the local histograms of apparent difusion coefficient in differentiation of brain astrocytomas
Authors: Mihailovic Jelena , Grujicic Danica , Lavrnic Slobodan , Dakovic Marko
Published: September 2017

Background/Aim. Microstructural diversity of brain astrocytomas makes their diagnostics and differentiation by using the diffusion weighted imaging (DWI) difficult. In this study we used the histogram-based positioning of regions of interests on the apparent diffusion coefficient (ADC) maps in order to restrict the determination of diffusion parameters to regions of interest (ROI) corresponding to maximum cellularity. Success of ADC standard deviation (?ADC) and kurtosis (K) in differentiation of brain astrocytomas was evaluated. Methods. The thirtyone patients (16 women and 15 men, median age 37 years, age range 6?72 years) with suspected supratentorial astrocytomas were included in the retrospective study. The magnetic resonance imaging (MRI) examinations were performed using the 1.5 T MR system (Avanto; Siemens, Erlangen, Germany) and 8-channel phased array head coil. The DWI images were acquired in three orthogonal directions for the b-values 0, 500 and 1000 s mm-2. The histogram calculations and determination of diffusion parameters were performed using the MIPAV software package and the statistical analysis was done in the Openstat software. Results. The ADC values enabled differentiation of diffuse astrocytomas (DA) from a high-grade astrocytoma (HGA), but not between the classes of HGA. In addition, the ?ADC value provided discrimination between the anaplastic astrocytoma (AA) and glioblastoma multiforme (GBM) with 100% of sensitivity and 89% of specificity . The kurtosis value can also differentiate between the grades AA and GBM although with the lower sensitivity and specificity. Conclusion. The histogram analysis of tumor region on the ADC maps can provide a guidance for an appropriate choice of the ROIs. The parameters which characterize diffusion of such defined ROIs, as well as their combination can improve differentiation of brain astrocytomas.
ABO blood group and risk of glioma: A case control study from Serbia
Authors: Azanjac-Arsic Ana , Miletic-Drakulic Svetlana , Vesic Katarina , Toncev Gordana
Published: September 2017

Backgraund/Aim. Gliomas are the most common primary brain tumors and the etiology is unknown. The aim of this study was to investigate possible association between incidence in relation to glioma and certain blood groups. Methods. The case-control study included 100 pathologically confirmed cases of glioma at the Clinical centar of Kragujevac, Serbia, between 2014 and 2015, and 200 age and sex-matched controls without malignant diseases in personal and family history at the same institution. After signing the informed consent, all patients filled out an epidemiological questionnaire. Results. In the analysis comparing the glioma patients with the control group, a significant association (p < 0.0005) was observed in relation to the blood group AB. Furthermore, it was not observed a significant association in relation to the blood group A (p = 0.070), blood group B (p = 0.256), blood group O (p = 0.768) among the compared groups. Also, in the analysis comparing glioma patients with the control group, a significant association was observed in relation to the years spent in hometown (p = 0.035), changing the place of residence (p = 0.007), the body weight (p = 0.002) and the body mass index (p < 0.0005). Univariate binary logistic regression showed that higher number of years spent in the hometown [odds ratio (OR) 1.011 95% confidence interval (Cl) 1.000? 1.023; p = 0.043], increased body weight (OR 0.976 95% Cl 0.959?0.993, p = 0.006) and increased body mass index (OR 0.898 95% Cl 0.839?0.961; p = 0.002) increase the risk of glioma. However, a change of the residence decreases the risk of glioma (OR 0.327 95% Cl 0.147?0.727; p = 0.006). Univariate binary logistic regression analysis revealed that the individuals with group AB were at 3.5-fold increased risk of developing glioma compared to the individuals with other ABO blood groups (OR 3,429 95% Cl 1,83?6,41; p < 0.0005). Also, there was more male patients with glioma with the blood group AB (p = 0.001). Conclusion. In a present study, we demonstrate that individuals with the group AB have an increased risk of developing glioma.
Impact of the hyperbaric oxygen therapy on the redox status in patients with systemic lupus erythematosus
Authors: Rabrenovic Milorad , Nikolic Tamara , Rabrenovic Violeta , Bradic Jovana , Tresnjic Sasa , Petkovic Anica , Jakovljevic Biljana , Masic Sinisa , Bokonjic Dubravko
Published: September 2017

Background/Aim. Hyperbaric oxygen therapy (HBOT) is a method which increases oxygen solubility in plasma up to 20 times. This effect is very important in the treatment of circulatory disorders, which reduces oxygenation and leads to increased production of inflammatory mediators and free oxygen radicals. The aim of this study was to examine the impact of HBOT on the oxidative stress parameters in the patients with systemic lupus erythematosus (SLE). Methods. This prospective study included 18 females with SLE [American College of Rheumatology (ACR) criteria], average age 52.2 ? 8.82 years, treated with HBOT for 60 min/day, with average partial oxygen pressure of 2.2 atmospheres absolute (ATA), during 10 days, in combination with appropriate medication therapy for SLE. The following parameters were determined in the serum: C-reactive protein (CRP), hemoglobin, creatinine, albumin, complement 3 (C3), antinuclear antibodies (ANA), glomerular filtration rate (GFR) using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula. In the urine, parameters of oxidative stress were spectrofotometrically determined: levels of superoxide anion radical (O2 ??), hydrogen peroxide (H2O2), nitrites (NO2-) and concentration of thiobarbituric acid reactive substances (TBARS). In hemolysate, the parameters of antioxidant protection: superoxide dismutase (SOD), catalase (CAT) and reduced gluthatione (GSH), were measured. The samples for the analysis were collected three times: before HBOT (initial values), after 10 days of HBOT and 1 month after beginning the treatment in relation to the initial value. Results. We noticed a statistically significant (p < 0.05) decrease in a level of O2 ??, both after 10 days and after 1 month of HBOT (8.26 ? 13.62; 8.39 ? 4.94; 11.92 ? 6.86 nmol/mL, respectively). Values of other parameters of oxidative stress such as NO2-, TBARS and H2O2- showed no significant difference during the monitored period. Regarding the parameters of antioxidant the protection, we revealed slightly higher value of GSH after treatment (initial value: 66.34 ? 16.31; after 10 days of HBOT 79.43 ? 36.77; after 1 month of HBOT69.72 ? 22.32 ?mol/mL red blood cells) which was held after a month, but it was not statistically significant. Activity of SOD and CAT, before and after HBOT, did not change significantly. Conclusion. Our results suggested the potential beneficial effects of HBOT on redox status in the patients with SLE by decreasing the levels of O2??.
Advanced magnetic resonance techniques in early differentiation of pseudoprogression versus progression in the patients with glioblastoma multiforme
Authors: Mihailovic Jelena , Dakovic Marko
Published: September 2017

Background/Aim. The diagnosis of glioblastoma multiforme progression may be confounded by a phenomena termed pseudoprogression (PSP) and pseudoresponse (RCT) which has become more common with the adoption of radiation therapy with concurrent and adjuvant application of temozolomide (CRT). Distinguishing of these phenomena is based on the follow-up scans since no single imaging method or technique is yet capable of performing their discrimination. In this study, we evaluated the dynamic susceptibility contrast (DSC perfusion) imaging and magnetic resonance (MR) spectroscopy to predict the prognosis and time to progression in the patients with glioblastoma multiforme. Methods. Fourty patients with primary glioblastoma multiforme were included in the analysis. The patients were examined in 3rd week after surgery and 10th week after the beginning of CRT. The MR exams were performed using the 1.5 T MR scanner (Avanto; Siemens, Erlangen, Germany). The maps of perfusion parameters and time-to-peak (TTP) parameter were calculated using the DPTools v3.79 software. The 3D CSI PRESS MR spectroscopy was performed in the area corresponding to the contrast enhancement on the T1W images. Results. Thirty-two of the 40 patients had progressive disease and 8 had pseudoprogression. Progressive disease showed the mean time of the peak values of 33 ? 7 s in 3rd and 30 ? 5 s in 10th week with no statistical significance between these two periods (p > 0.05). The patients with pseudoprogression showed the mean time of the peak values of 32 ? 8 s in 3rd week and 43 ? 9 s in 10th week; it was statistically significant difference (p < 0.05) was which favors better response to therapy. The spectroscopy results showed presence of glycine peak at 3.56 ppm in 6 patients with progressive disease which was not seen on spectra with pseudoprogression. Conclusion. The observed significant differences in the TTP values for PSP and RCT can provide basis for distinguishing two entities. The presence of glycine peak in the MR spectra could be a marker of RCT.
Six-months success of radiofrequency ablation in cardiac arrhythmias treatment: Experience of our centre
Authors: Jurcevic-Mudric Ruzica , Angelkov Lazar , Tomovic Milosav , Kojic Dejan , Milojevic Predrag
Published: September 2017

Background/Aim. Numerous trials have shown a high success of radiofrequency ablation (RFA) in the treatment of the patients with cardiac arrhythmias. We aimed to examine the RFA initial success in treatment of different cardiac arrhythmias and the RFA success after 6 months of followup. Second aim was to evaluate influence of all clinical and echocardiography parameters on initial and 6-month success and failure of RFA. Methods. The present study included 320 consecutive patients with atrial and ventricular arrhythmias in which RFA was performed during 2014 in the Institute for Cardiovascular Diseases ?Dedinje?, Belgrade, Serbia. We evaluated the initial RFA success and success of this procedure after 6-month follow-up. We also investigated the prognostic role of clinical and echocardiography parameters on initial and 6-month success and failure of RFA. Results. The RFA initial success for RFA of atrioventriculas (AV) node and AV nodal reentrant tachycardia (AVNRT) was 100%, RFA of pulmonary veins 99%, RFA of atrial flutter 92%, RFA of premature ventricular complexes (PVC) and the Wolf-Parkinson-White (WPW) syndrome 87%, RFA of ventricular tachycardia 85% and RFA of atrial tachycardia 78%. The success of RFA after 6 months of follow-up for RFA of the AV node was 100%, RFA of AVNRT 94%, RFA of atrial flutter 90%, RFA of WPW syndrome 86%, RFA of pulmonary veins 79% (paroxysmal atrial fibrillation 88% and persistent atrial fibrillation 63% with a significant difference p < 0.05), RFA of PVC 78%, RFA of ventricular tachycardia 77% and RFA of atrial tachycardia 67%. Conclusion. This study proved a very high RFA initial success in treatment of cardiac arrhythmias and a satisfactory RFA success after 6 months of follow-up. Only the prognostic value had the type of atrial fibrillation in the group with catheter ablated pulmonary veins: after 6-month follow-up, the patients with paroxysmal atrial fibrillation had a significantly better outcome than those with persistent form.
Platelet aggregability and anticoagulant proteins activity during dobutamine stress echocardiography in asymptomatic patients four months after percutaneous coronary intervention
Authors: Jovic Zoran , Subota Vesna , Dzudovic Boris , Mladenovic Zorica , Maric-Kocijancic Jelena , Djuric Predrag , Spasic Marijan , Djenic Nemanja , Romanovic Radoslav , Miloradovic Vladimir , Matunovic Radomir , Obradovic Slobodan
Published: September 2017

Introduction: Platelets aggregability (PA) and the activation of hemostasis,
during myocardial ischemia within physical or mental stress, can be one of
many factors that influence the process of stent thrombosis after
percutaneous coronary intervention (PCI). Objective: The aim of the study is
to investigate the relationship between PA and activity of anticoagulant
proteins with myocardial ischemia during dobutamine stress echocardiography
(DSE) in asymptomatic patients four months after PCI. Methods: The study
population included 74 asymptomatic patients who had successful PCI four
months before high-dose dobutamine stress echocardiography (DSE).PA on
epinephrine (EPI) and adenosine diphosphate (ADP) were determined by Light
Transmission Aggregometry (LTA), together with plasma activity of protein C
(PC) and antithrombin (AT) before DSE and at the peak stage of the stress
test. Patients were divided into several groups whether they have baseline or
induced disturbance of segmental myocardial kinetics or not. All patients
were on clopidogrel and aspirin therapy at the time of DSE. Results: There
were no statistically significant difference in PA on ADP (47.50% vs. 50.20%;
p=0.970) as well as on EPI (59.30% vs. 60.30%, p=0.600) before and at the
peak DSE. A statistically significant difference was found in the
anticoagulant activity of the AT (84.85% vs. 74.75%, p=0.001) and PC (77.75%
vs. 67.60%, p<0.001). Significance of differences in antithrombin and the
protein C, refers to the result before and at the peak levels of the test.
There was no significant difference in PA and plasma activity of
anticoagulant proteins in patients with or without induced myocardial
ischemia at the peak of DSE. Patients who had increased wall motion score
index (WMSI) at the peak of DSE had higher EPI induced PA (68.60% vs. 54.70%
p=0.017) than patients with normal myocardial contractility. Conclusion:
There are no changes in the PA before and after DSE, however, plasma activity
of anticoagulant proteins decreased at the peak level of the test. Platelet
aggregability on EPI significantly increases at the peak of DSE in patients
with segmental myocardium hypocontractility.
The significance of smoking as a risk factor for the disorder of the obstructive pulmonary pattern in the patients with systemic sclerosis
Authors: Stefanovic-Neskovic Jelena , Petronijevic Milan , Ristic Andjelka , Djurovic Branka , Stevic-Carevic Silvija , Neskovic Branimir
Published: September 2017

Background/Aim. Systemic sclerosis (SSc) is a chronic systemic disease of the connective tissue. It is characterized by diffuse microangiopathy, increased activity and creating deposits of collagen in the skin and internal organs. Involvement of the lung function disturbances in SSc is a bad prognostic sign. The aim of our study was to investigate the association between smoking habits and lung function disorder in the SSc patients. Methods. The testing was conducted at the Clinic for Rheumatology and Immunology of the Military Medical Academy in 2016. In this study, we included 42 patients with the newly diagnosed SSc and the patients whose disease had been diagnosed earlier. Results. The patients were classified according to the smoking habits, 14 (33.3%) patients were nonsmokers, while 28 (66.7%) patients were current (23 patients) or ex-smokers (5 patients). We found no significant differences in examined parameters among smokers and nonsmokers. In addition, distribution of the patients with the obstructive pulmonary pattern revealed by spirometry was uniform between smokers and nonsmokers. The concentrations of C reactive protein (CRP) were significantly higher in the SSc patients with the obstructive pulmonary pattern. The patients with the obstructive pattern on spirometry had significantly lower values of forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), FEV1/FVC ratio, diffusing lung capacity for carbon monoxide (DLCO) and FVC/DLCO ratio. Conclusion. In our study, we concluded that in the SSc patients with the obstructive pulmonary pattern revealed by spirometry, there were no significant differences between smokers and nonsmokers. CRP is a significant predictor of the lung involvement existence in the SSc patients.
Retroperitoneoscopic nephrectomy for a nonfunctioning kidney
Authors: Sekulic Vuk , Bogdanovic Jovo , Herin Ranko , Djozic Senjin , Popov Mladen
Published: September 2017

Background/Aim. The minimally invasive laparoscopic nephrectomy was first performed in 1991. The objective of this paper was to present the surgical technique of retroperitoneoscopic nephrectomy and to our experience with this procedure in removal of non-functioning kidneys. Methods. This retrospective study enrolled 55 patients who underwent retroperitoneoscopic nephrectomy at our institution during the period from January 2011 to November 2016. All patients had a unilateral non-functioning kidney confirmed by intravenous or computed tomography (CT)- urography and renal scintigram. Their medical records were analyzed for demographic data, duration of surgery, average blood loss, duration of hospital stay as well as time to return to normal life activities. Results. The mean age of patients was 43 years (range 23?78). Perioperative or early postoperative mortality was not recorded. Mean operative time was 82 minutes (range 45?210). The average blood loss was 90 mL (40?450). The average hospital stay was 4 days (3?7). Return to life activity was in average after 12 days (9?15). Conclusions. Retroperitoneoscopic nephrectomy for a non-functioning kidney is a feasible, safe, and effective minimally invasive method. The length of hospital stay and convalescence was shorter than after open nephrectomy.
Spirometric changes in children with asthma exposed to environmental tobacco smoke and treated with inhaled corticosteroids
Authors: Radic Snezana , Milenkovic Branislava , Gvozdenovic Branislav , Medjo Biljana , Dimic-Janjic Sanja
Published: September 2017

Background/Aim. Corticosteroids are the most frequently prescribed anti-inflammatory treatment in asthma. A purpose of this study was to compare the spirometric parameters as a response to inhaled fluticasone propionate (FP) treatment in children with asthma, exposed and nonexposed to environmental tobacco smoke (ETS). Methods. The study included 527 children aged between 1 and 16 years with persistent asthma divided into the groups of ETS exposed (ETSE, n = 337) and ETS free (ETSF, n = 190) children. Spirometry was performed before (1st set of results) and after 6 months of FP treatment (2nd set of results). Good lung function (GLF) was defined as forced expiratory volume in one second (FEV1) ? 85%, and ?poor lung function? (PLF) as FEV1 < 85%. Results. Among the ETSE children, 208 had one smoking parent, 129 had two, 228 had smoking mothers and 238 smoking fathers. The ETSE children received a higher FP dose (p < 0.0001) which was increased with the increase of the number of smokers in the family. The ETSE children had significantly lower lung function both in the 1st and 2nd sets of tests compared to the ETSF children (p < 0.05). After the FP treatment, both groups improved all spirometric parameters (p < 0.001). In the 2nd set of the spirometric tests, the children of smoking mothers had lower spirometry values compared to the children of smoking fathers (p < 0.05). The proportion of the children improving from the PLF to GLF after 6 months of FP was much higher among the ETSF than the ETSE children (p < 0.05). Conclusions. The ETSE children had lower spirometric values before FP. After 6-months of the FP treatment children in both groups improved the spirometric values, but the improvement was higher in the ETSF children.
Risk factors for recurrent Clostridium difficile infection among patients in the Clinical Centre of Vojvodina, Serbia: A retrospective clinical trial
Authors: Kovacevic Nadica , Doder Radoslava , Preveden Tomislav , Pete Maria
Published: September 2017

Background/Aim. In the last two decades the incidence of recurrent Clostridium difficile infection (CDI) has risen. The aim of this study was to determine the risk factors for the recurrent CDI among patients hospitalized with the initial CDI. Methods. We conducted a retrospective clinical trial at the Clinic for Infectious Diseases, Clinical Center of Vojvodina, Serbia, between January 2010 and January 2016. We enrolled 488 patients with the initial CDI who were treated with oral vancomycin (125 mg, 4 times per day) or oral metronidazole (400 mg, 3 times per day) for 10 days. After the completion of therapy, there was 60 days of the follow-up period for the assessment of the rates of relapse. To determine the risk factors for the CDI relapse, we compared the demographics, clinical and laboratory characteristics of the patients who had a relapse with the patients who had a stable clinical response. Results. Of the 488 cases, 29.09% recurred. The relapse occured in 22.72% patients who received vancomycin and in 36.60% patients treated with metronidazole (p = 0.038). A statistically significant effect on the CDI relapse had the comorbidities such as a malignancies (19.52% vs 8.82%, p = 0.023) and the postoperative CDI (25.67% vs 10.29%, p = 0.035), hipoalbuminemia (< 25 g/L) (70.27% vs 41.94%; p = 0.034) and the concomitant antibiotic therapy (50.67% vs 20.29%; p = 0.031). The persistence of C. difficile toxin in the stool at the end of treatment was registered in 22.32% of patients treated with metronidazole vs 9.09% of patients given vancomycin (p = 0.03). Conclusion. Our data suggest that the important risk factors for the CDI relapse are comorbidities (surgery within a month before developing CDI and malignancy), hipoalbuminemia (< 25g/L) and concomitant non-CDI antibiotics therapy. Vancomycin is more effective than metronidazole in the elimination of C. difficile toxins. The presence of C. difficile toxins in the stool after the successful completion of the initial CDI therapy does not affect significantly the occurrence of relapse.
The impact of breast augmentation on the skin temperature of the breast
Authors: Piscevic Branislav , Brdareski Zorica , Stepic Nenad , Djordjevic Boban , Vulovic Dejana , Jovanovic Marko , Vulovic Dejan
Published: September 2017

Background/Aim. Complications of breast augmentation, as one of the most common cosmetic surgery, may be different. Besides usual early, local postoperative complicatons, the most common late complication is capsular contracture. As a specific complication of skin functions after this operation only disturbance of sensibility is described. Since the skin has other functions as well, and because there are no literature data available, the aim of this research was measuring the skin temperature before and after surgery. Methods. A prospective intervential study was done in 49 adult women. Bilateral augmentative mammaplasty was performed for breast hypoplasia or on the personal request of a patient with autrophic breasts. Measuring the temperature of the breast skin was done in two points, before the operation, and seven days and three months after surgery. The temperature measurement was done by the infrared thermometer (Pyrometer TROTEC BP21). Statistically significant difference was determined using the t-test for related samples. Differences were considered statistically significant if p was less than 0.05. Eta squared coefficient was use to determine the import size and according to the Cohen criteria everything over 10:14 signified a major impact. The data were analyzed by the IBP SPSS Statistics v20. Results. In a majority of patients the breasts were hypoplastic (69.39%). The most commonly used implants were 275?500 mL volume (46.94%), and the least common implants were over 500 mL (16.33%). In a little less than 2/3 of the patients submammary incision was used (61.22%). In a majority of patients (67.35%) the prosthesis were placed subglandularly. The average value of the temperature before the operation at the point 1 was 34.49?C, seven days after surgery 34.81?C, and three months after surgery 34.10?C; and at the point 2: 34.60 ?C, 34.91?C and 34.19?C in the same time intervals. In relation to the size of the breasts before operation and the size of the implant manufacturer, the localization of the incision and placement of the localization of the prosthesis, no statistically significant differences in the temperature of the skin of the breast before and after surgery was observed. Conclusion. Our results on the change of skin temperature after the breast augmentation could be significant preoperative information for the patients.
Clear cell/endometrioid type ovarian carcinoma associated with endometriosis of the ipsilateral ovary
Authors: Rudic-Biljic-Erski Ivana , Vasiljevic Mladenko , Rakic Snezana , Dzatic-Smiljkovic Olivera , Mihajlovic Sladjana
Published: September 2017

Introduction. Ovarian endometriosis has been identified as a risk factor for occurrence of endometriosis-associated ovarian carcinoma. We presented a rare case of simultaneous clear cell/ endometrioid ovarian carcinoma and endometriosis of the ipsilateral ovary. Case report. A 47-yearold patient underwent surgery for right ovarian endometriotic cyst. A total hysterectomy with bilateral salpingooophorectomy, lymphadenectomy in the right psoas muscle region and omentectomy were performed as well as multiple peritoneal biopsies. Six cycles of chemotherapy were instituted postoperatively using the Taxol-CBDCA protocol. Abdominal and pelvic CT did not demonstrate recurrence of the disease postoperatively and after completed chemotherapy treatment. Six months after the completion of treatment, the patient felt well without the disease recurrence. Conclusion. Clear cell and endometrioid subtypes of ovarian carcinoma have good prognosis if they are diagnosed and treated at an early stage of the disease. In our patient, the carcinoma was detected in the first stage and successfully treated with combination therapy, i.e., surgical and chemotherapy.
Severe imported malaria in a Serbian referral center
Authors: Poluga Jasmina , Karic Uros , Dakic Zorica , Katanic Natasa , Lavadinovic Lidija , Milosevic Branko , Nikolic Natasa , Urosevic Aleksandar , Jegorovic Boris , Pavlovic Milorad
Published: September 2017

Background/Aim. The World Health Organization estimates that 3.2 billion people are at a risk of being infected with malaria. Thus, the adequate diagnostic protocols for malaria, especially those aimed at determining disease severity, are paramount both in endemic and non-endemic setting. The aim of this study was to identify the demographic, parositological, clinical and laboratory characteristics associated with severe malaria in a non-endemic settings. Methods. We analyzed 22 patients with severe malaria and compared their clinical and laboratory findings with those of the patients with non-severe malaria in a search of predictors of disease severity. All patients were treated at the Infectious and Tropical Diseases University Hospital, Clinical Centre of Serbia in Belgrade, Serbia from 2000 to 2010. Results. The average age of patients with with severe malaria was 44.86 ? 12.33 years and men predominated (95.45%). The patients with severe malaria were infected Plasmodium falciparum (P. falciparum) significantly more frequently compared with those with non-severe disease (p =0.047). Jaundice was the most commonly observed feature of severe malaria, followed by anemia and renal failure. The multifactor analysis of variance showed that thrombocytopenia (p = 0.05) and high serum tumor necrosis factor-alpha levels (p = 0.02) were significantly associated with the disease severity. Conclusion. A high index of suspicion for malaria should be maintained when evaluating febrile patients returning from the malaria endemic regions. The elevated serum tumor necrosis factor-alpha levels and thrombocytopenia are associated with severe malaria in non-endemic settings.
Diabetes mellitus - factors that contribute to the occurrence, diagnosis and management of the disease
Authors: Cizmic Milica , Ristic Petar , Djuran Zoran , Karajovic Jelena , Zoranovic Uros , Nenezic Nemanja
Published: September 2017

nema
Dental management of patients taking antiplatelet, oral anticoagulant and novel anticoagulant medications
Authors: Bajkin Branislav , Mirkovic Sinisa , Vucinic Predrag , Vuckovic Biljana , Marjanovic Marjan
Published: September 2017

nema
Tecnologías de materiales compuestos
Authors: Escandón Juan Manuel
Published: September 2017

Los materiales poliméricos presentan características que permiten diversas aplicabilidades, es por ello que en este artículo, se describen tecnología utilizada y la distribución de las fibras según el tipo de composite  sus características ingenieriles, y los factores que influyen.
Plantas piloto: Una nueva opción en la formación técnica
Authors: Quiñones Iber James , Vera Mondragón Bairo Vera Mondragón
Published: September 2017

Profesionales de los Centros ASTIN y CEAI del SENA Regional Valle diseñaron y construyeron diversas plantas de procesos químicos, en busca de apoyar los procesos de formación que ofrece el Centro Multisectorial de Barrancabermeja (CMB), donde se imparten los programas de formación integral de Técnico Profesional Operador de Plantas y Tecnólogo en Procesos Químicos Industriales para operación de plantas de las diferentes empresas de los sectores Petroquímica y Oleoquímica.
Implementación y certificación del Sistema de Gestión de Calidad
Authors: Lenis Gil Gustavo Adolfo
Published: September 2017

Se describe la importancia de la implementación y certificación del Sistema de Gestión de Calidad en la competitividad dentro del mercado mundial;  las diferentes etapas que deben tener las empresas para la implementación y la certificación para así, lograr aprender a capitalizar las experiencias e incorporarlas, con rapidez y adecuación, las variantes del entorno económico, satisfaciendo las necesidades y expectativas de los clientes.
Editorial
Authors: Narváez Agudelo Aura Elvira
Published: September 2017

Editorial
¿Cómo embarcarse en proyectos tecnológicos?
Authors: Winterfeldt Lutz
Published: September 2017

Se describe uno de los procedimientos que el autor y sus colaboradores usan para abordar proyectos tecnológicos, esperando que le sirva al lector como guía en su propia búsqueda de una metodología clara y sencilla, fácil de seguir.
Aspectos analíticos y tecnológicos del proceso de punzonado de chapa (2da Parte)
Authors: Mateos S. , Rico J.C , Cuesta E. , Valiño G.
Published: September 2017

Se describen los aspectos tecnológicos del proceso  de las máquinas punzonadoras, que han evolucionado hacia máquinas automáticas e integradas permitiendo abarcar la fabricación de una amplia gama de piezas sobre la misma máquina y con escasa influencia sobre sus costos de preparación.
Polipropileno reforzado con fibra de yute – ¿Una alternativa al refuerzo con fibra de vidrio?
Authors: Wuttke B. , Hinrichsen G.
Published: September 2017

En este artículo se menciona la importancia de la búsqueda de nuevas aplicaciones para las fibras naturales diferentes a las textiles, y desarrollar las respectivas tecnologías que se necesitan para ello, por ejemplo, un posible uso como fibras de refuerzo para termoplásticos.
Sistemas para la adquisición de puntos en máquinas de medir por coordenadas
Authors: Onaciu Traian
Published: September 2017

En los procesos de control de calidad se manifiesta, de manera constante, la necesidad de sistemas más acertados de evaluación de las características geométricas individuales o de subconjuntos de los productos industriales. Entre la diversidad de medios implicados en encontrar solución al problema mencionado, la MMC (Máquina de medir por coordenadas) es el medio más complejo y eficaz.
El reciclaje de medios de almacenamiento de datos ópticos
Authors: Hahnsen H. , Orth P. , Schmitt M. , Tappe R.
Published: September 2017

Se plantea como opción de reciclaje los discos compactos,  como fuente de materia prima para plásticos de ingeniería de alta calidad. Sin embargo, se mencionó que por razones ecológicas y económicas este objetivo solo se puede alcanzar en la práctica con altos flujos volumétricos de artículos de desecho y residuos industriales, y con el desarrollo de una tecnología de reciclaje diseñada especialmente.
Nivelación y reglaje de máquinas troqueladoras
Authors: Sáenz Puentes Pedro María
Published: September 2017

Se describen las recomendaciones respecto a verificación de la nivelación y reglaje de las máquinas troqueladoras del constructor de máquinas, del alemán R. Schlesinge
Modelo para la gestión estratégica de la tecnología (GET)
Authors: Pedroza Alvaro
Published: September 2017

Se propone un modelo de cómo utilizar los factores críticos de éxito y las necesidades críticas tecnológicas de empresas pequeñas y medianas, durante el proceso de análisis de sus metas, fortalezas y debilidades, oportunidades y amenazas, con el fin de ligar la estrategia tecnológica a la estrategia general. El modelo está compuesto de 5 etapas; en cada etapa se toman decisiones y para cada una de ellas se proveen matrices de decisión y sus correspondientes tablas de información de soporte que alimenta a dichas matrices. Finalmente se proveen referencias para un seguimiento más detallado del modelo.
Elaboración de un producto a partir de plástico reciclado
Authors: Solís-Molina Miguel , Martinez Sergio Andres , De Mendoza Adriana , Cabal Hincapie Rodrigo
Published: September 2017

Este proyecto planteó una propuesta mediante la cual la Cooperativa de Recicladores "Nuevas Luces" podría adoptar tecnología que le permitiría incursionar en áreas de mayor valor agregado. Para ello, se lleva a cabo un estudio del subsector de la transformación del plástico reciclado, que involucra el análisis de materiales, productos, procesos y mercados. El estudio es evaluado bajo los principios del desarrollo sostenible ecoeficiencia, equidad social y crecimiento económico, planteando, finalmente, posibles cursos de acción para darle continuidad a esta línea de investigación.
Moldeo por inyección: Control del proceso
Authors: AG BAYER
Published: September 2017

Se describe el control del proceso y sus propósitos en el moldeo por inyección de plásticos y lo que se debe tener en cuenta para la preparación de una producción que incluye tanto el ajuste y la optimización de los parámetros de la máquina, el arranque de la producción y su constante supervisión.
Progression i högre utbildning
Authors: Säfström Anna Ida
Published: September 2017

Syftet med denna studie är att undersöka innebörden och användningen av ordet progression inom högre utbildning. För att ta reda på i vilka betydelser ordet progression används, och hur användningen av ordet har förändrats över tid, genomförs här en systematisk begreppsanalys av vetenskapliga texter, statliga styrdokument och texter hämtade från svenska lärosätens hemsidor. Som utgångspunkt för analysen särskiljs progression i dess klassiska betydelse och progression som en kvalitet i utbildning, undervisning och läromedel. Resultatet av analysen visar att ordet progression används i allt högre utsträckning, men ofta med oklar betydelse. Det framkom också att det har skett en förskjutning mot användning av ordet progression som kvalitet hos utbildning. En definition av utbildningsprogression föreslås, och konsekvenser för högre utbildning diskuteras.
Ischio-pubic osteochondritis (Van Neck-Odelberg disease): A case report
Authors: Iqbal Muhammad , Naeem Muhammad , Babar Imran Muhammad , Shahzad Afzal Muhammad , Saeed Akhtar Muhammad
Published: September 2017

Background:

Ischio-pubic Osteochondritis is characterized by an atypical ossification pattern of the ischio-pubic synchondrosis. Radiologically it may mimic stress fracture, neoplasm, osteomyelitis, or post-traumatic osteolysis. 99mTc-MDP bone scintigraphy with SPECT/CT is one of the effective tools for its diagnosis.

Case presentation:

A male patient, 11 years of age visited nuclear medicine department of our hospital with complaint of pain in the right hip with no history of fever, trauma or fall. There were no signs of inflammation or swelling at the site of pain. X-ray showed lytic lesion in the right inferior ischio-pubic ramus with area of lucencies. A 99mTc-methylene diphosphonate (99mTc-MDP) bone scan showed focal area of increased uptake in the right inferior ischio-pubic ramus. SPECT/CT hybrid imaging showed areas of demineralization at the edges of ischio-pubic synchondrosis with areas of sclerosis, findings compatible with Ischio-pubic osteochondritis. Patient was later treated with anti-inflammatory drugs and steroids.

Conclusion:

Ischio-pubic Osteochondritis is one of the differential diagnosis in children presenting with pain in the groin, hip or gluteal region and limping gait. Ample awareness of this ailment is necessary for early diagnosis and proper management, to alleviate the suffering of child.
Practising multimedia presentation skills for high school students
Authors: Hồng Xuân Phan Thị
Published: September 2017

The Industrial Revolution 4.0 has put mankind before the challenges of changing. In order to participate in a flat world, people can not just use the traditional way of communication but also need the help of modern means. Presentation is not out of that rule and becomes multimedia. This article explores the issue of practising multimedia presentation skills for high school students in literature classes.
The Most Desired Positions: Brazilian Female Drug Traffickers in Inferno and Falcão: Mulheres e o tráfico
Authors: Castellanos Gonella Carolina
Published: September 2017

In order to analyze the gender performance and empowerment of Brazilian female drug traffickers, this article compares the character of Marta in Patrícia Melo’s novel Inferno (2000) with the testimonies of four real female drug traffickers collected in MV Bill and Celso Athayde’s book Falcão: Mulheres e o tráfico (2007). It argues that while female drug traffickers highlight their experience and use their kinship relations, Marta’s access to power and gender transgression are temporary because her community and other drug traffickers do not support her. The article also proposes the term “the most desired positions” to replace “hegemonic masculinities” because of the prominence that cisgender and trans women have begun to have in the world of drug trade.
The Problematic Alleviating Suffering Argument: Why genetic Engineering Is Unnecessary
Authors: Dürnholz Lorena
Published: September 2017

Few topics are as controversial today as genetic engineering, which would allow parents to screen and subsequently modify the genome of their unborn children. Advocates commonly argue that genetic engineering is desirable because it could prevent diseases and dis- abilities and in this way alleviate suffering. However, this argument relies on a simplistic and one-sided view of health. By adopting a more relational perspective, it becomes clear that genetic engineering is unnecessary, firstly because the amount of suffering asso- ciated with the genetic conditions it could prevent is much lower than one might expect, and secondly because the suffering that might nevertheless be present can also be alleviated by other means, which are to be preferred.
Irony's Potential as Subversive Strategy: A Case Study of Anti-Racist Stand-Up Comedy
Authors: Ortmanns Charlotte
Published: September 2017

In this paper, I evaluate the potential of irony to subvert racist discourse.Irony is characterised by semantic forms that engage explicitand implicit language so as to communicate oppositional or contradictorymeanings for satirical or contentious purposes. This processis complicated as meaning often remains contested betweenthe author of a statement and its various interpreters. My analysis ofthe stand-up comedian Aamer Rahman’s work shows how irony canbe used by comedians in order to subvert dominant and exploitativediscourses. In particular, I illustrate how irony provides him with atool to evoke and simultaneously distance himself from anti-Muslimracist discourses. For white audiences with an interest in deconstructingtheir own complicity in racism, his comedy can functionas a Critical Public Pedagogy that enables critical self-reflection.
From Ceramic Centre to Creative Hub
Authors: Hesemans Hanna
Published: September 2017

This paper investigates how the concept of the Creative Hub – a term employed to define spaces of creativity that foster knowledge, innovation and economic growth – can form a positive addition to the creative redevelopment of the former Sphinx factory buildings in Maastricht. The policy of the European Creative Hub Network initiated by the British Council with support of the European Commission in the beginning of 2016 is applied to the policies of the Maastricht municipality with respect to the former Sphinx Factory. After setting up preliminary categories from the policy documents of the British Council, a research method of coding is employed to investigate the policy documents of the municipality of Maastricht. Similarities and differences are then highlighted. It is concluded that the Sphinx could benefit from more community involvement, individual initiative, a bottom up approach, a broader definition of creativity, less focus on regeneration, more flexibility and more inclusiveness.
Aachen’s Policies on Air Pollution: A Law and Economics Analysis
Authors: Moraal Mareike
Published: September 2017

This article compares the merits of two opposing air pollution policies in Aachen through a law and economics approach. Based on Cole’s property rights regimes, the current Aachener Approach and the soon to replace it Low Emission Zone (LEZ) are characterized as incentive-based and command-and-control regulation respectively, and subsequently evaluated on their efficiency and effectiveness using local government reports and legislation, and theoretical law and economics literature. This cost-benefit analysis shows the LEZ to be less efficient and of questionable effectivity in achieving reduction of air pollution levels compared to the current Aachener Approach.
Reminscences of Morals
Authors: Sheikh Nahal
Published: September 2017

In atrocities, bystanders might find themselves in a limbo-like state where it is extremely difficult to react responsibly to an occurring injustice. This article investigates the complex bystander character through a social-psychological analysis of Ari Folman's animated documentary film, Waltz with Bashir (2008). Theories of norm learning and delinquent behaviour are used to understand the unconscious self-perception of the protagonist, Ari, of his bystander role in the Sabra and Shatila Massacre of 1982. It is claimed that while Ari sees himself as a perpetrator of the massacre unconsciously, his behaviour as an innocent witness bearing no ethical responsibility creates a disruptive tension that endlessly haunts him.
Introduction
Authors: Waern Annika , Zagal José
Published: September 2017

The Digital Games Research Association - DiGRA - celebrated its 10th anniversary in 2011. Espen Aarseth declared 2001 as the â€œyear one of computer game studies as an emerging, viable, international, academic fieldâ€ (Aarseth 2001). As of this writing, the DIGRA conference has been organized five times and DiGRA is now taking the next step, to publish its own journal.
Replacing preconceived accounts of digital games with experience of play: When parents went native in GTA IV
Authors: Schott Gareth , Van Vught Jasper
Published: September 2017

Cautionary frameworks continue to dominate evaluations of games within political contexts, obstructing consideration of the specific conditions and experiences offered by particular game texts. This paper challenges this tendency of prior government-instigated research to promote viewpoints that are not textually evaluative or play-derived when reporting on perceptions of games possessed by the public. Instead, it prioritizes Dovey and Kennedyâ€™s (2006) argument that â€˜we cannot have recourse solely to [games] textual characteristics; we have to pay particular attention to the moment of its enactment as it is played.â€™ More concretely, this paper describes research sparked by the NZ Classification Officeâ€™s interest in exploring â€˜the extent to which the publicâ€™s perception of causal links between game playing and various social illsâ€™ might be â€˜moderated or even undermined by [knowledge of] how players actually respond to and negotiate their way through the content and characteristics of the mediumâ€™ (OFLC 2009, 24). Using both game-play observation and in-depth interviews, we concluded that the participantsâ€™ preconceptions of Grand Theft Auto IV (Rockstar North, 2008) were drastically reevaluated after experience playing the game, shifting attitudes and beliefs as to how games should be regulated.