bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical characteristics of combined rosacea and migraine
Authors: Wienholtz Nita K. F. , Christensen Casper E. , Zhang Ditte G. , Rechnagel Anne-Sofie A. , Byrnel Helene V. S. , Haugaard Jeanette H. , Ashina Messoud , Thyssen Jacob P. , Egeberg Alexander
Published: October 2022

Background

An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear.

Objective

The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine.

Methods

In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine.

Results

We found a prevalence of migraine of 54% in patients with rosacea, and a prevalence of rosacea of 65% in patients with migraine. Concomitant migraine was significantly associated with the rosacea features flushing (odds ratio = 2.6, 95% confidence interval = 1.4–4.7, p = 0.002), ocular symptoms (odds ratio = 2.4, 95% confidence interval = 1.5–3.9, p < 0.001), and burning (odds ratio = 2.1, 95% confidence interval = 1.3–3.4, p = 0.002), whereas papules/pustules were inversely related with concomitant migraine (odds ratio = 0.5, 95% confidence interval = 0.3–0.8, p = 0.006). No association was found between concomitant migraine and centrofacial erythema, rhinophyma, telangiectasia, edema, or dryness. Concomitant rosacea was not associated with any specific migraine subtype in patients with migraine.

Conclusion

This study highlights a substantial overlap between rosacea and migraine, particularly in patients with certain rosacea features. Individuals with rosacea should be asked about concomitant migraine, and comorbidities should be considered when choosing between treatments.
Two rare diseases, acute calcific retropharyngeal tendinitis, and crowned dens syndrome, mimicking meningitis: A case report
Authors: Igami Eriko , Fukae Jiro , Kanazawa Kazo , Fuse Atsuhito , Nakajima Asuka , Eguchi Hiroto , Hattori Nobutaka , Shimo Yasushi
Published: October 2022

We report two rare cases. One involved acute calcific retropharyngeal tendinitis, an inflammatory condition of the longus colli tendon triggered by the deposition of calcium hydroxyapatite crystals. The other involved crowned dens syndrome, caused by pseudogout of the atlantoaxial junction following deposition of calcium pyrophosphate dehydrate or calcium hydroxyapatite. Although these two diseases involve different mechanisms, the common symptoms of neck pain and fever resemble those of meningitis. Accurate diagnosis can thus be difficult without background knowledge of these conditions. Cerebrospinal fluid examination and cervical computed tomography are useful for distinguishing these pathologies from meningitis.
Variation of vitamin B contents in maize inbred lines: Potential genetic resources for biofortification
Authors: Safiul Azam Fardous Mohammad , Lian Tong , Liang Qiuju , Wang Weixuan , Zhang Chunyi , Jiang Ling
Published: October 2022

Vitamin B and its derivatives possess diverse physiological functions and are essential micronutrients for humans. Their variation in crops is important for the identification of genetic resources used to develop new varieties with enhanced vitamin B. In this research, remarkable variations were observed in kernels of 156 maize inbred lines, ranging from 107.61 to 2654.54 μg per 100 g for vitamin B1, 1.19–37.37 μg per 100 g for B2, 19.60–213.75 μg per 100 g for B3, 43.47–590.86 μg per 100 g for B5, and 138.59–1065.11 μg per 100 g for B6. Growing inbreeds in Hainan and Hebei provinces of China revealed environmental and genotype interactions among these vitamins and the correlations between them in maize grain. Several inbred lines were identified as good sources of vitamin B and promising germplasms for maize breeding, namely By855 and Si273 are overall rich in all the studied vitamins, and GY386B and CML118 are specially enriched with derivatives of vitamin B6. The present study can assist maize breeders with germplasm resources of vitamin B for biofortification to offer people nutritious foods.
Molecularly imprinted polymer-specific solid-phase extraction for the determination of 4-hydroxy-2(3H)benzoxazolone isolated from Acanthus ilicifolius Linnaeus using high-performance liquid chromatography-tandem mass spectrometry
Authors: Ma Xingbin , Lin Hongling , Yong Yanhong , Ju Xianghong , Li Youquan , Liu Xiaoxi , Yu Zhichao , Wujin Cuomu , She Yongxin , Zhang Jiyu , Abd El-Aty A. M.
Published: October 2022

The minor constituent found in Acanthus ilicifolius Linnaeus, 4-hydroxy-2 (3H) benzoxazolone alkaloid (HBOA), has a range of versatile applications. Herein, a quick and straightforward method for extracting HBOA from A. ilicifolius Linnaeus was proposed. HBOA was used as a template, whereas methacrylic acid, ethylene glycol dimethacrylate, and acetonitrile were used as functional monomers, cross-linkers, and porogens, respectively. Molecularly imprinted polymers (MIPs) were synthesized by precipitation polymerization, and their adsorption isotherms, dynamics, and selective binding ability were characterized and analyzed. The results showed that the adsorption amount of the template was 90.18 mg/g. The MIPs were used as solid-phase extraction fillers and actual sample extraction columns, with a linear range of 0–100 μg/L, average recovery of 78.50–101.12%, and a relative standard deviation of 1.20–3.26%. The HBOA concentrations in the roots, stems, and leaves were 1,226, 557, and 205 μg/g, respectively. In addition, MIP–SPE was successfully used in isolating and purifying HBOA from different parts of A. ilicifolius Linnaeus, indicating its effectiveness in extracting and determining HBOA in other herbs.
Tumor microenvironment in non-melanoma skin cancer resistance to photodynamic therapy
Authors: Cerro Paulina A. , Mascaraque Marta , Gallego-Rentero María , Almenara-Blasco Manuel , Nicolás-Morala Jimena , Santiago Juan Luis , González Salvador , Gracia-Cazaña Tamara , Juarranz Ángeles , Gilaberte Yolanda
Published: October 2022

Non-melanoma skin cancer has recently seen an increase in prevalence, and it is estimated that this grow will continue in the coming years. In this sense, the importance of therapy effectiveness has increased, especially photodynamic therapy. Photodynamic therapy has attracted much attention as a minimally invasive, selective and repeatable approach for skin cancer treatment and prevention. Although its high efficiency, this strategy has also faced problems related to tumor resistance, where the tumor microenvironment has gained a well-deserved role in recent years. Tumor microenvironment denotes a wide variety of elements, such as cancer-associated fibroblasts, immune cells, endothelial cells or the extracellular matrix, where their interaction and the secretion of a wide diversity of cytokines. Therefore, the need of designing new strategies targeting elements of the tumor microenvironment to overcome the observed resistance has become evident. To this end, in this review we focus on the role of cancer-associated fibroblasts and tumor-associated macrophages in the resistance to photodynamic therapy. We are also exploring new approaches consisting in the combination of new and old drugs targeting these cells with photodynamic therapy to enhance treatment outcomes of non-melanoma skin cancer.
Association of metastatic nodal size with survival in non-surgical non-small cell lung cancer patients: Recommendations for clinical N staging
Authors: Zhang Yanan , Liu Zhehui , Wang Hongmin , Liang Fengfan , Zhu Liqiong , Liu Haifeng
Published: October 2022

Background

This study aims to analyze the prognostic significance of the metastatic lymph node (mLN) size in non-small cell lung cancer (NSCLC) patients receiving chemoradiotherapy (CRT) to provide some information for the optimization of clinical nodal (cN) staging.

Methods

A retrospective study with 325 NSCLC patients was conducted between January 2011 and December 2018 at two participating institutes. We evaluated the potential relationship between the mLN size and the survival to propose a potential revised nodal (rN) staging.

Results

Kaplan–Meier analyses showed significant differences in the overall survival (OS) based on the cN staging and the size of mLNs (N0, ≤2 cm, and >2 cm). We found that the nodal size correlated statistically with the response to CRT. The HRs of OS for patients with bulky mLNs increase significantly compared with patients in the non-bulky mLNs group in the cN2-3 group. Interestingly, the HRs of patients with bulky cN2 disease and non-bulky cN3 disease were similar to each other. We classified the patients into five subsets: N0, rN1(cN1), rN2(non-bulky cN2), rN3a(bulky cN2, and non-bulky cN3), and rN3b(bulky cN3). In our study, the rN stage showed better prognostic discrimination than the 8th IASLC cN staging and was an independent prognostic factor for survival.

Conclusions

In addition to the anatomic location, the size of mLNs correlated statistically with the response to CRT and should be incorporated into the cN staging system to predict survival more accurately.
The Analgesic Museum
Authors: Koebner Ian J. , Bonilla Bethney , Slatman Jenny , Parry Manon
Published: October 2022

This manuscript uses the perspectives and insights that emerged from the Analgesic Museum conference held virtually on March 11, 2022 as a mechanism for considering the role museums and artists can play in the public health effort to reduce the burden of persistent pain. One hundred and fifty-seven individuals from 22 countries registered for the Analgesic Museum conference. The event explored the intersection of art and pain management practices with presentations centered on three domains of interest: exhibition development, arts experiences and practices, and research and creative scholarship.
The developing brain: Challenges and opportunities to promote school readiness in young children at risk of neurodevelopmental disorders in low- and middle-income countries
Authors: Hadders-Algra Mijna
Published: October 2022

This paper discusses possibilities for early detection and early intervention in infants with or at increased risk of neurodevelopmental disorders in low- and middle-income countries (LMICs). The brain's high rate of developmental activity in the early years post-term challenges early detection. It also offers opportunities for early intervention and facilitation of school readiness. The paper proposes that in the first year post-term two early detection options are feasible for LMICs: (a) caregiver screening questionnaires that carry little costs but predict neurodevelopmental disorders only moderately well; (b) the Hammersmith Infant Neurological Examination and Standardized Infant NeuroDevelopmental Assessment (SINDA) which are easy tools that predict neurodisability well but require assessment by health professionals. The young brain's neuroplasticity offers great opportunities for early intervention. Ample evidence indicates that families play a critical role in early intervention of infants at increased risk of neurodevelopmental disorders. Other interventional key elements are responsive parenting and stimulation of infant development. The intervention's composition and delivery mode depend on the infant's risk profile. For instance, in infants with moderately increased risk (e.g., preterm infants) lay community health workers may provide major parts of intervention, whereas in children with neurodisability (e.g., cerebral palsy) health professionals play a larger role.
Compact neutron source from head-on collision of high energy density plasma jets
Authors: Cui Ye , Ke Yan-Zhao , Yang Xiao-Hu , Ma Yan-Yun , Shao Fu-Qiu
Published: October 2022

We propose a new scheme to generate a neutron source with a short duration, and the scheme is validated in two-dimensional radiation hydrodynamic simulations. When a laser beam irradiates a deuterated polystyrene cone with a half-opening angle of 60°, high energy density plasma jets are produced due to the converging effect. As two laser-driven counter-propagating jets collide in a head-on configuration, the kinetic energy converts into internal energy efficiently, inducing a significant increase in density and temperature. Then, deuteron–deuteron thermonuclear reactions are triggered, and plenty of neutrons are released. The simulation results show that the total neutron yield is as high as 6.6×108 with a duration of 103 ps, providing a new way to achieve ultrafast diagnosis with high resolution in experiments.
Determinants of ventilatory inefficiency in transthyretin cardiac amyloidosis: The role of excessive ventilatory drive
Authors: Monfort Astrid , Thevenet Eugenie , Lacavalerie Mickael Rejaudry , Banydeen Rishika , Inamo Jocelyn , Neviere Remi
Published: October 2022

Background and objective: Along with impaired aerobic capacity, increased slope of the relationship between ventilation (VE) and pulmonary CO2 output (VCO2), i.e., VE-VCO2 slope is a common finding in patients with cardiac amyloidosis (CA), which suggests ventilatory inefficiency. Little is known about mechanisms leading to ventilatory inefficiency in CA patients. The purpose of this investigation was to examine the factors that underlie the abnormal ventilatory efficiency in transthyretin hereditary CA patients, such as excessive ventilatory drive, inability of pulmonary blood flow to increase adequately during exercise and excessive sympathetic stimulation, which are known mechanisms of VE-VCO2 slope increase.

Methods: In this single-center retrospective observational study, consecutive patients (n = 41) with known familial transthyretin amyloidosis p.Val142Ile mutation carriers with confirmed cardiac phenotype were included.

Results: Compared with CA patients without ventilatory inefficiency (VE-VCO2 slope < 36), patients with ventilatory inefficiency (VE-VCO2 slope ≥ 36) had increased inter-ventricular septum thickness, lower VO2 peak along with hyperventilation, and prolonged post-exercise heart rate recovery. By multivariate analysis, only excess of minute-ventilation at anaerobic threshold (β = 0.127; p = 0.011) remained an independent predictor of ventilatory inefficiency.

Conclusion: Our data suggest that high ventilatory stimulation during exercise leading to hyperventilation is the main determinant of ventilatory inefficiency in hereditary transthyretin cardiac amyloidosis patients. This novel finding helps to better understand the mechanism of exercise intolerance in these patients where physiological limitation may be related to both heart dysfunction and abnormal pulmonary response.
Global transcriptome analysis reveals potential genes associated with genic male sterility of rapeseed (Brassica napus L.)
Authors: Jiang Jianxia , Xu Pengfei , Zhang Junying , Li Yanli , Zhou Xirong , Jiang Meiyan , Zhu Jifeng , Wang Weirong , Yang Liyong
Published: October 2022

Rapeseed is the third leading source of edible oil in the world. Genic male sterility (GMS) lines provide crucial material for harnessing heterosis for rapeseed. GMS lines have been widely used successfully for rapeseed hybrid production. The physiological and molecular mechanism of pollen development in GMS lines of rapeseed (Brassica napus L.) need to be determined for the creation of hybrids and cultivation of new varieties. However, limited studies have focused on systematically mining genes that regulate the pollen development of GMS lines in B. napus. In the present study, to determine the stage at which pollen development begins to show abnormality in the GMS lines, we performed semi-thin section analysis of the anthers with five pollen development stages. The results indicated that the abnormal pollen development in DGMS lines might start at the meiotic stage, and abnormal pollen development in RGMS lines probably occurred before the tetrad stage. To investigate the critical genes and pathways involved in pollen development in GMS lines, we constructed and sequenced 24 transcriptome libraries for the flower buds from the fertile and sterile lines of two recessive GMS (RGMS) lines (6251AB and 6284AB) and two dominant GMS (DGMS) lines (4001AB and 4006AB). A total of 23,554 redundant DEGs with over two-fold change between sterile and fertile lines were obtained. A total of 346 DEGs were specifically related to DGMS, while 1,553 DEGs were specifically related to RGMS. A total of 1,545 DEGs were shared between DGMS and RGMS. And 253 transcription factors were found to be differentially expressed between the sterile and fertile lines of GMS. In addition, 6,099 DEGs possibly related to anther, pollen, and microspore development processes were identified. Many of these genes have been reported to be involved in anther and microspore developmental processes. Several DEGs were speculated to be key genes involved in the regulation of fertility. Three differentially expressed genes were randomly selected and their expression levels were verified by quantitative PCR (qRT-PCR). The results of qRT-PCR largely agreed with the transcriptome sequencing results. Our findings provide a global view of genes that are potentially involved in GMS occurrence. The expression profiles and function analysis of these DEGs were provided to expand our understanding of the complex molecular mechanism in pollen and sterility development in B. napus.
Manure properties, soil conditions and managerial factors regulate greenhouse vegetable yield with organic fertilizer application across China
Authors: Xiang Yangzhou , Li Yuan , Luo Xuqiang , Liu Ying , Yue Xuejiao , Yao Bin , Xue Jianming , Zhang Leiyi , Fan Jing , Xu Xiuyue , Li Yonghua
Published: October 2022

To better understand the responses of vegetable yields in a greenhouse system to organic fertilizer through a quantitative evaluation based on peer-reviewed journal articles and in consideration of environmental managerial factors. We conducted a meta-analysis of 453 paired observations from 68 peer-reviewed journal articles to assess the response of vegetable yields in greenhouse vegetable systems in China to organic fertilization. Compared with the control (no organic fertilizer), organic fertilization significantly increased the yields of vegetables by 44.11% on average. The response of vegetable yields to organic fertilizer tended to increase with the increasing experimental duration. Organic fertilizer application had the greatest potential for leafy vegetables (+76.44%), in loamy soils (+53.94%), at moderate organic fertilizer carbon input levels (+54.13%), and in soils with moderate initial soil total nitrogen levels (+50.89%). Aggregated boosted tree analysis indicated that organic fertilizer carbon inputs, vegetable type and experimental duration were the predominant factors that manipulated the response of vegetable yields to organic fertilizer application. The rational application of farmyard manure would be a promising strategy for increasing vegetable yields in greenhouse vegetable systems in China. Factoring in vegetable type, carbon and nitrogen inputs of organic fertilizer, and soil texture would benefit vegetable yields with the application of organic fertilizer.
Say that again: Quantifying patterns of production for children with autism using recurrence analysis
Authors: Mankovich Amanda , Blume Jessica , Wittke Kacie , Mastergeorge Ann M. , Paxton Alexandra , Naigles Letitia R.
Published: October 2022

The current research study characterized syntactic productivity across a range of 5-year-old children with autism and explored the degree to which this productivity was associated with standardized measures of language and autism symptomatology. Natural language samples were transcribed from play-based interactions between a clinician and participants with an autism diagnosis. Speech samples were parsed for grammatical morphemes and were used to generate measures of MLU and total number of utterances. We applied categorical recurrence quantification analysis, a technique used to quantify patterns of repetition in behaviors, to the children’s noun-related and verb-related speech. Recurrence metrics captured the degree to which children repeated specific lexical/grammatical units (i.e., recurrence rate) and the degree to which children repeated combinations of lexical/grammatical units (i.e., percent determinism). Findings indicated that beyond capturing patterns shown in traditional linguistic analysis, recurrence can reveal differences in the speech productions of children with autism spectrum disorder at the lexical and grammatical levels. We also found that the degree of repeating noun-related units and grammatical units was related to MLU and ADOS Severity Score, while the degree of repeating unit combinations (e.g., saying “the big fluffy dog” or the determiner-adjective-adjective-noun construction multiple times), in general, was only related to MLU.
Individualized prediction of chronic kidney disease for the elderly in longevity areas in China: Machine learning approaches
Authors: Su Dai , Zhang Xingyu , He Kevin , Chen Yingchun , Wu Nina
Published: October 2022

Background

Chronic kidney disease (CKD) has become a major public health problem worldwide and has caused a huge social and economic burden, especially in developing countries. No previous study has used machine learning (ML) methods combined with longitudinal data to predict the risk of CKD development in 2 years amongst the elderly in China.

Methods

This study was based on the panel data of 925 elderly individuals in the 2012 baseline survey and 2014 follow-up survey of the Healthy Aging and Biomarkers Cohort Study (HABCS) database. Six ML models, logistic regression (LR), lasso regression, random forests (RF), gradient-boosted decision tree (GBDT), support vector machine (SVM), and deep neural network (DNN), were developed to predict the probability of CKD amongst the elderly in 2 years (the year of 2014). The decision curve analysis (DCA) provided a range of threshold probability of the outcome and the net benefit of each ML model.

Results

Amongst the 925 elderly in the HABCS 2014 survey, 289 (18.8%) had CKD. Compared with the other models, LR, lasso regression, RF, GBDT, and DNN had no statistical significance of the area under the receiver operating curve (AUC) value (>0.7), and SVM exhibited the lowest predictive performance (AUC = 0.633, p-value = 0.057). DNN had the highest positive predictive value (PPV) (0.328), whereas LR had the lowest (0.287). DCA results indicated that within the threshold ranges of ~0–0.03 and 0.37–0.40, the net benefit of GBDT was the largest. Within the threshold ranges of ~0.03–0.10 and 0.26–0.30, the net benefit of RF was the largest. Age was the most important predictor variable in the RF and GBDT models. Blood urea nitrogen, serum albumin, uric acid, body mass index (BMI), marital status, activities of daily living (ADL)/instrumental activities of daily living (IADL) and gender were crucial in predicting CKD in the elderly.

Conclusion

The ML model could successfully capture the linear and nonlinear relationships of risk factors for CKD in the elderly. The decision support system based on the predictive model in this research can help medical staff detect and intervene in the health of the elderly early.
Dependence of radiation belt flux depletions at geostationary orbit on different solar drivers during intense geomagnetic storms
Authors: Gokani Sneha A. , Han De-Sheng , Selvakumaran R. , Pant Tarun Kumar
Published: October 2022

The loss of electron flux of the outer radiation belt has been widely studied in terms of the mechanism that brings in these losses. There are a few studies which have attempted to explain the interplanetary conditions that favor the depletions. As the Sun is the prime cause of any change happening in the magnetosphere, it is important to look at the solar drivers that bring in such changes. In this study, we attempt to understand the effect of solar structures and substructures on the loss of radiation belt high-energy electrons during intense geomagnetic storms. The superposed epoch analysis is used to observe any peculiar changes in GOES electron flux data during the storms that are associated with solar structures such as CME and CIR, ICME substructures such as the magnetic cloud, magnetic cloud with sheath, ejecta, ejecta with sheath, and only sheath. The long-term data also give an opportunity to compare the flux decrease during solar cycles 23 and 24. It has been observed that 1) CIR-associated storms cause a comparatively higher flux decrease than CME-associated storms, 2) sheath-related storms bring out a higher flux decrease, and 3) there is no significant change in flux for the storms of both the solar cycles. The flux decrease in intense storms at the geostationary orbit is essentially triggered by the “Dst effect.” Apart from this, the minimum IMF Bz and northward IMF Bz before turning southward add to the flux decrease. These results hold true for the electron depletions occurring only during intense geomagnetic storms and may alter otherwise.
Injury characteristics in Norwegian male professional football: A comparison between a regular season and a season in the pandemic
Authors: Dalen-Lorentsen Torstein , Andersen Thor Einar , Thorbjørnsen Christian , Brown Michael , Tovi David , Braastad Anders , Lindinger Tom Gerald , Williams Christian , Moen Eirik , Clarsen Benjamin , Bjørneboe John
Published: October 2022

The Coronavirus Disease-19 (COVID-19) pandemic forced the Norwegian male premier league football season to reschedule, reducing the fixture calendar substantially. Previous research has shown that a congested match schedule can affect injury rates in professional football. Therefore, we aimed to investigate whether the Norwegian premier league teams suffered more injuries in the more match congested 2020 season than in the regular 2019-season. We invited all teams having participated in both seasons to export their injury data. Only teams that used the same medical staff to register injuries in both seasons were included, and to maximize data comparability between seasons, we applied a time-loss injury definition only. Seven of 13 teams agreed to participate and exported their injury data. Both seasons had 30 game weeks, but the 2020 season was 57 days shorter than the 2019 season. The match injury incidence did not differ significantly [incidence rate ratio 0.76 (0.48–1.20; p = 0.24) in the 2020 season compared to the 2019 season. Furthermore, we found no differences in the number of injuries, days lost to injury, matches missed to injury, or injury severity. We could not detect any differences between the two seasons, suggesting the congested match calendar combined with the safety measures in the 2020 season can be a safe alternative in future seasons.
Nitrogen budgets and nitrogen use efficiency as agricultural performance indicators in Lake Victoria basin
Authors: Ntinyari Winnie , Gweyi-Onyango Joseph , Giweta Mekonnen , Mutegi James , Mochoge Benson , Nziguheba Generose , Masso Cargele
Published: October 2022

Too little nitrogen (N) is a threat to crop productivity and soil fertility in sub-Saharan Africa (SSA). Nitrogen budgets (NB) and nitrogen use efficiency (NUE) are critical tools for assessing N dynamics in agriculture and have received little or no attention in the region. Data were collected from smallholder farmers clustered into two categories, farmers applying and farmers not applying N fertilizers. NB were calculated using the Coupled Human and Natural Systems (CHANS) model approach for field and farm spatial scales. The results showed spatial variabilities in NB and NUE at the field level (maize and rice) across all the catchments. At the field level, N balances were negative for the two crops in all the catchments. Similarly, at the farm gate, a deficit of −78.37 kg N ha−1was observed, an indicator of soil N mining. NUE values at the field scale varied across the catchments for both crops, with values for maize grown without N ranging from 25.76 to 140.18%. Even with the application of mineral N at higher levels in rice fields compared to maize fields, NUE values ranged between 81.92 and 224.6%. Our study revealed that the Lake Victoria region suffers from inefficient N cycling due to depleted soil N pools and low synchrony between N input and N removal. Therefore, a challenge lies in exploiting more sustainable N sources for farmers in the region for sustainable farming systems. The NB and NUE provide critical information to agriculture stakeholders to develop environmental, agronomic, and economically viable N management solutions.
Special Issue: “Assessment and Rehabilitation of Existing Reinforced Concrete Structures and Infrastructures: Methods, Techniques and New Frontiers”
Authors: Gino Diego , Bertagnoli Gabriele
Published: October 2022

In the last several decades, assessment and rehabilitation of the existing built environment constitute two of the major challenges for engineers, practitioners, and code-makers all over the world [...]
Dose Reduction and Image Quality Optimization of Pediatric Chest Radiography Using a Tungsten Filter
Authors: Kim Eunhye , Muroi Kenzo , Koike Takahisa , Kim Jungmin
Published: October 2022

The use of diagnostic radiology in pediatric patients has increased, and various positive effects have been reported, including methods to reduce radiation doses in children. Research has been conducted to preserve image quality while reducing exposure and doses in pediatric patients. This study aimed to measure four different filters to identify an optimized filter for pediatric patients. The experiment was conducted using four types of filters, including aluminum, copper, molybdenum, and tungsten. The optimal filter thickness was verified using a histogram to visually evaluate the spectrum by filter thickness, effective dose on a pediatric phantom, entrance skin dose, organ absorbed dose using the PC-based Monte Carlo (PCXMC) program version 2.0 simulation, figure of merit (FOM), and image quality. As a result of measuring the spectrum according to the tube voltage and the four types of filters, dose reduction and contrast improvement effects were obtained with a 0.05 mm tungsten filter. Additionally, effective entrance skin and organ absorbed dose decreased with the said filter. The aluminum, copper, and molybdenum filters demonstrated that the effective dose scarcely decreased even when the thickness was increased; meanwhile, the effective dose decreased when the tungsten filter was 0.05 mm. The FOM with a 0.05 mm tungsten increased by 91% in the lung field and 39% in the mediastinal field. The entrance skin and organ absorbed dose in pediatric patients can be reduced by removing low-energy photons that fail in image formation using a tungsten filter.
Prevention and Therapy of Metastatic HER-2+ Mammary Carcinoma with a Human Candidate HER-2 Virus-like Particle Vaccine
Authors: Ruzzi Francesca , Palladini Arianna , Clemmensen Stine , Strøbæk Anette , Buijs Nicolaas , Domeyer Tanja , Dorosz Jerzy , Soroka Vladislav , Grzadziela Dagmara , Rasmussen Christina Jo , Nielsen Ida Busch , Soegaard Max , Semprini Maria Sofia , Scalambra Laura , Angelicola Stefania , Landuzzi Lorena , Lollini Pier-Luigi , Thorn Mette
Published: October 2022

Vaccines are a promising therapeutic alternative to monoclonal antibodies against HER-2+ breast cancer. We present the preclinical activity of an ES2B-C001, a VLP-based vaccine being developed for human breast cancer therapy. FVB mice challenged with HER-2+ mammary carcinoma cells QD developed progressive tumors, whereas all mice vaccinated with ES2B-C001+Montanide ISA 51, and 70% of mice vaccinated without adjuvant, remained tumor-free. ES2B-C001 completely inhibited lung metastases in mice challenged intravenously. HER-2 transgenic Delta16 mice developed mammary carcinomas by 4–8 months of age; two administrations of ES2B-C001+Montanide prevented tumor onset for >1 year. Young Delta16 mice challenged intravenously with QD cells developed a mean of 68 lung nodules in 13 weeks, whereas all mice vaccinated with ES2B-C001+Montanide, and 73% of mice vaccinated without adjuvant, remained metastasis-free. ES2B-C001 in adjuvant elicited strong anti-HER-2 antibody responses comprising all Ig isotypes; titers ranging from 1–10 mg/mL persisted for many months. Antibodies inhibited the 3D growth of human HER-2+ trastuzumab-sensitive and -resistant breast cancer cells. Vaccination did not induce cytokine storms; however, it increased the ELISpot frequency of IFN-γ secreting HER-2-specific splenocytes. ES2B-C001 is a promising candidate vaccine for the therapy of tumors expressing HER-2. Preclinical results warrant further development towards human clinical studies.
Appraisal of Satellite Rainfall Products for Malwathu, Deduru, and Kalu River Basins, Sri Lanka
Authors: Perera Helani , Senaratne Nipuna , Gunathilake Miyuru B. , Mutill Nitin , Rathnayake Upaka
Published: October 2022

Satellite Rainfall Products (SRPs) are now in widespread use around the world as a better alternative for scarce observed rain gauge data. Upon proper analysis of the SRPs and observed rainfall data, SRP data can be used in many hydrological applications. This evaluation is very much necessary since, it had been found that their performances vary with different areas of interest. This research looks at the three prominent river basins; Malwathu, Deduru, and Kalu of Sri Lanka and evaluates six selected SRPs, namely, IMERG, TRMM 3B42, TRMM 3B42-RT, PERSIANN, PERSIANN-CCS, PERSIANN-CDR against 15+ years of observed rainfall data with the use of several indices. Four Continuous Evaluation Indices (CEI) such as Root Mean Square Error (RMSE), Percentage Bias (PBIAS), Pearson’s Correlation Coefficient (r), and Nash Sutcliffe Efficiency (NSE) were used to evaluate the accuracy of SRPs and four Categorical Indices (CI) namely, Probability of Detection (POD), Critical Success Index (CSI), False Alarm Ratio (FAR) and Proportion Correct (PC) was used to evaluate the detection and prediction accuracy of the SRPs. Then, the Mann–Kendall Test (MK test) was used to identify trends in the datasets and Theil’s and Sens Slope Estimator to quantify the trends observed. The study of categorical indicators yielded varying findings, with TRMM-3B42 performing well in the dry zone and IMERG doing well in the wet zone and intermediate zone of Sri Lanka. Regarding the CIs in the three basins, overall, IMERG was the most reliable. In general, all three basins had similar POD and PC findings. The SRPs, however, underperformed in the dry zone in terms of CSI and FAR. Similar findings were found in the CEI analysis, as IMERG gave top performance across the board for all four CEIs in the three basins. The three basins’ overall weakest performer was PERSIANN-CCS. The trend analysis revealed that there were very few significant trends in the observed data. Even when significant trends were apparent, the SRP projections seldom captured them. TRMM-3B42 RT had the best trend prediction performance. However, Sen’s slope analysis revealed that while the sense of the trend was properly anticipated, the amplitude of the prediction significantly differed from that of the observed data.
WPAxFuzz: Sniffing Out Vulnerabilities in Wi-Fi Implementations
Authors: Kampourakis Vyron , Chatzoglou Efstratios , Kambourakis Georgios , Dolmes Apostolos , Zaroliagis Christos
Published: October 2022

This work attempts to provide a way of scrutinizing the security robustness of Wi-Fi implementations in an automated fashion. To this end, to our knowledge, we contribute the first full-featured and extensible Wi-Fi fuzzer. At the time of writing, the tool, made publicly available as open source, covers the IEEE 802.11 management and control frame types and provides a separate module for the pair of messages of the Simultaneous Authentication of Equals (SAE) authentication and key exchange method. It can be primarily used to detect vulnerabilities potentially existing in wireless Access Points (AP) under the newest Wi-Fi Protected Access 3 (WPA3) certification, but its functionalities can also be exploited against WPA2-compatible APs. Moreover, the fuzzer incorporates: (a) a dual-mode network monitoring module that monitors, in real time, the behavior of the connected AP stations and logs possible service or connection disruptions and (b) an attack tool used to verify any glitches found and automatically craft the corresponding exploit. We present results after testing the fuzzer against an assortment of off-the-shelf APs by different renowned vendors. Adhering to a coordinated disclosure process, we have reported the discovered issues to the affected vendors, already receiving positive feedback from some of them.
How the Brain Becomes the Mind: Can Thermodynamics Explain the Emergence and Nature of Emotions?
Authors: Déli Éva , Peters James F. , Kisvárday Zoltán
Published: October 2022

The neural systems’ electric activities are fundamental for the phenomenology of consciousness. Sensory perception triggers an information/energy exchange with the environment, but the brain’s recurrent activations maintain a resting state with constant parameters. Therefore, perception forms a closed thermodynamic cycle. In physics, the Carnot engine is an ideal thermodynamic cycle that converts heat from a hot reservoir into work, or inversely, requires work to transfer heat from a low- to a high-temperature reservoir (the reversed Carnot cycle). We analyze the high entropy brain by the endothermic reversed Carnot cycle. Its irreversible activations provide temporal directionality for future orientation. A flexible transfer between neural states inspires openness and creativity. In contrast, the low entropy resting state parallels reversible activations, which impose past focus via repetitive thinking, remorse, and regret. The exothermic Carnot cycle degrades mental energy. Therefore, the brain’s energy/information balance formulates motivation, sensed as position or negative emotions. Our work provides an analytical perspective of positive and negative emotions and spontaneous behavior from the free energy principle. Furthermore, electrical activities, thoughts, and beliefs lend themselves to a temporal organization, an orthogonal condition to physical systems. Here, we suggest that an experimental validation of the thermodynamic origin of emotions might inspire better treatment options for mental diseases.
Evaluation of the Quality of the Housing Environment Using Multi-Criteria Analysis That Includes Energy Efficiency: A Review
Authors: Mazur Łukasz , Bać Anna , Vaverková Magdalena Daria , Winkler Jan , Nowysz Aleksandra , Koda Eugeniusz
Published: October 2022

The quality of the housing environment (HE) is an important issue that has a direct impact on the life of inhabitants. Aiming for quality in residential architecture begins with a well-designed HE, with the designing process being a value that is difficult to evaluate. Nowadays, a well-designed HE takes into account the energy efficiency of a building. An appropriate degree of thermal comfort, which is required by inhabitants, needs to be considered at the design stage. Designers can use building certification programs and multi-criteria analysis to motivate investors to construct buildings in accordance with energy efficiency requirements. These systems respond to the needs of energy efficiency, thermal comfort, sustainable heating, and ventilation. Defining ways and methods to evaluate quality in architectural projects will allow the value of the HE to be improved. For this purpose, a multi-criteria analysis of five systems that can be used to evaluate HE quality and energy efficiency in a temperate climate was conducted: (1) Building For Life 12, (2) Home Quality Mark, (3) Housing Quality Indicators, (4) Système D’évaluation De Logements (Sel), and (5) NF Habitat-NF Habitat HQE. This analysis concerned information about the systems, their applicability in practice, and the applied assessment measures. The article shows that the quality of the HE consists of specific factors that can be distinguished and indicated by evaluation systems. As a result of the carried out assessment of the housing environment, 13 original categories of building assessment criteria were defined. The results of the conducted analysis indicated that it is possible to: (i) identify factors for the improvement of HE quality; (ii) prepare objective systems for the measurement of the HE; and (iii) use such systems in practice, e.g., in the design industry, real estates, and public administration. Moreover, the systems can be used in legal regulations for updating urban policies.
Evaluation of the Operational Efficiency and Energy Efficiency of Rail Transit in China’s Megacities Using a DEA Model
Authors: Zhang Hao , Wang Xinyue , Chen Letao , Luo Yujia , Peng Sujie
Published: October 2022

To date, along with the rapid development of urban rail transit (URT) in China, the evaluation of operational efficiency and energy efficiency has become one of the most important topics. However, the extant literature regarding the efficiency of URT at the line level and considering carbon emissions is limited. To fill the gap, an evaluation model based on slacks-based measure (SBM) data envelopment analysis (DEA) is proposed to measure the efficiencies, which is applied to 61 URT lines in China’s four megacities. The findings are summarized as follows: (1) The average operational efficiency and energy efficiency of URT lines are low, and both have great room for improvement. (2) There are significant disparities in the efficiency of URT lines in the case cities. For instance, the average operational efficiency of URT lines in Guangzhou is higher than that of other cities, while the average energy efficiency of URT lines in Shanghai is higher than that of other cities. (3) The URT lines operated by state-owned enterprises have higher average operational efficiency, while the lines operated by joint ventures have higher average energy efficiency. Finally, some suggestions are provided to improve the efficiencies.
Evaluating and Enhancing the Energy Efficiency of Representative Residential Buildings by Applying National and International Standards Using BIM
Authors: Albdour Mohammad S. , Shalby Mohammad , Salah Ahmad A. , Alhomaidat Fadi
Published: October 2022

Due to the chronic shortage of energy-related analytical data and disintegration of building energy regulations, numerous existing residential buildings in Petra (Jordan) and many cities worldwide suffer from poor building energy design. This paper aims at investigating the potential of applying energy-saving standards in order to improve the whole-building energy consumption of low-rise residential buildings in mild and dry climate zones. Representative buildings were selected based on a field survey. Proposed strategies focused on applicable solutions such as envelope components, and energy-related systems were set. The models were created using Autodesk Revit, and then the results were generated by the EnergyPlus engine. The findings showed that the application of building energy standards greatly impacts the overall energy end-use, where up to 30% reduction can be achieved by applying the Jordanian code, and up to 45% by applying the American standard. This work provides guidance for the residential building industry and policymakers in Jordan and many other countries with similar building characteristics and climate zones.
Comparison of LID and Electrical Injection Regeneration of PERC and Al-BSF Solar Cells from a Cz-Si Ingot
Authors: Ding Siqi , Yang Chen , Qin Cheng , Ai Bin , Sun Xiaopu , Yang Jianghai , Liu Quan , Liang Xueqin
Published: October 2022

In order to study the effect of device structures and silicon wafer positions on light-induced degradation (LID) and regeneration, five groups of industrial PERC and Al-BSF solar cells were fabricated by using silicon wafers from different positions of a B-doped Czochralski silicon (Cz-Si) ingot. Then, the cells were subjected to a dark annealing (200 °C, 30 min), the first LID (45 °C, 1 sun, 12 h), an electrical injection regeneration (175 °C, 18 A, 30 min) and the second LID (45 °C, 1 sun, 12 h) in order, and the variations of performance of the cells with processing time were measured. It was found that after the electrical injection regeneration, the efficiency losses of PERC cells decreased from 1.28–1.76%absolute in the first LID to 0.09–0.16%absolute in the second LID, while those of Al-BSF cells decreased from 0.3–0.66%absolute in the first LID to 0 in the second LID. The efficiency losses of PERC cells during the first LID were caused by the co-action of B-O-defect-induced LID (BO-LID) and dissociation of Fe-B pairs, and the latter contributed 5.81–9.56% of the efficiency loss, while those of Al-BSF cells during the first LID were almost contributed by BO-LID solely. For both kinds of cells, the cells made from the silicon wafers from middle of the ingot had the best performance throughout the experiment. In addition, the LID and regeneration treatments only affected the spectral response of the cells in the wavelength larger than 700 nm.
Structure Optimization Research Based on Numerical Simulation of Flow Field in Ammonia-Based Wet Sintering Flue Gas Desulfurization
Authors: Li Ling , Zhang Buting , Zhu Ping , Yu Liangying , Zhao Guangjin , Li Min , Wang Hecen
Published: October 2022

Although more and more desulfurization equipment has been put into use in sintering plants, how to effectively remove sulfur dioxide from sintering flue gas in a desulfurization tower is still a great challenge in China. The desulfurization tower, as a critical part, needs further improvement and optimization. Therefore, based on the numerical simulation of the flow field of the ammonia-based wet desulfurization tower for sintering flue gas, ANSYS CFX is applied to conduct structural optimization research. Comparing the flow field distribution under different structure conditions, the results show that the flue gas distribution of the dual inlet tower is more uniform than that of the single inlet tower. The designed baffle not only effectively blocks the entry of the spray slurry, but also improves the flue gas distribution; the deflector with its simple structure, convenient operation, and stepped distribution installed in the entrance section can improve the uniformity of the flow field distribution. Based on the comprehensive analysis, these optimized structures are recommended in the design of an ammonia-based wet sintering flue gas desulfurization tower. This work not only develops a simulation of the desulfurization tower but also provides practical structures.
Fault Detection in HVDC System with Gray Wolf Optimization Algorithm Based on Artificial Neural Network
Authors: Jawad Raad Salih , Abid Hafedh
Published: October 2022

Various methods have been proposed to provide the protection necessitated by the high voltage direct current system. In this field, most of the research is confined to various types of DC and AC line faults and a maximum of two switching converter faults. The main contribution of this study is to use a new method for fault detection in HVDC systems, using the gray wolf optimization method along with artificial neural networks. Under this method, with the help of faulted and non-faulted signals, the features of the voltage and current signals are extracted in a much shorter period of the signal. Subsequently, differences are detected with the help of an artificial neural network. In the studied HVDC system, the behavior of the rectifier, along with its controllers and the required filters are completely modeled. In this study, other methods, such as artificial neural network, radial basis function, learning vector quantization, and self-organizing map, were tested and compared with the proposed method. To demonstrate the performance of the proposed method the accuracy, sensitivity, precision, Jaccard, and F1 score were calculated and obtained as 99.00%, 99.24%, 98.74%, 98.00%, and 98.99%, respectively. Finally, according to the simulation results, it became evident that this method could be a suitable method for fault detection in HVDC systems.