bluuebunny/crossref_metadata_2025 huggingface dataset:
Arctic sea ice melt onset favored by an atmospheric pressure pattern reminiscent of the North American-Eurasian Arctic pattern
Authors: Horvath Sean , Stroeve Julienne , Rajagopalan Balaji , Jahn Alexandra
Published: April 2021

The timing of melt onset in the Arctic plays a key role in the evolution of sea ice throughout Spring, Summer and Autumn. A major catalyst of early melt onset is increased downwelling longwave radiation, associated with increased levels of moisture in the atmosphere. Determining the atmospheric moisture pathways that are tied to increased downwelling longwave radiation and melt onset is therefore of keen interest. We employed Self Organizing Maps (SOM) on the daily sea level pressure for the period 1979–2018 over the Arctic during the melt season (April–July) and identified distinct circulation patterns. Melt onset dates were mapped on to these SOM patterns. The dominant moisture transport to much of the Arctic is enabled by a broad low pressure region stretching over Siberia and a high pressure over northern North America and Greenland. This configuration, which is reminiscent of the North American-Eurasian Arctic dipole pattern, funnels moisture from lower latitudes and through the Bering and Chukchi Seas. Other leading patterns are variations of this which transport moisture from North America and the Atlantic to the Central Arctic and Canadian Arctic Archipelago. Our analysis further indicates that most of the early and late melt onset timings in the Arctic are strongly related to the strong and weak emergence of these preferred circulation patterns, respectively.
Predictors of adenoma size and location in primary hyperparathyroidism
Authors: Filser Barbara , Uslar Verena , Weyhe Dirk , Tabriz Navid
Published: April 2021

Purpose

In primary hyperparathyroidism (PHPT), intraoperative localization of the parathyroid adenoma can be challenging, especially in cases of negative preoperative imaging. Since a focused unilateral parathyroidectomy has benefits compared to a conventional bilateral neck exploration, the question arises whether adenoma size prediction can facilitate a targeted approach. We investigated whether single parathyroid adenoma size can be estimated using preoperative parathyroid hormone (PTH), calcium, and phosphate in patients with PHPT. Preoperative imaging accuracy was evaluated.

Methods

The data of 156 patients who underwent curative parathyroidectomy for single adenoma PHPT were analyzed retrospectively. Information obtained included laboratory data, imaging results, intraoperative data, and final pathology. Imaging accuracy was analyzed descriptively. The association between preoperative biochemical markers and adenoma dimensions was investigated using Spearman’s correlation coefficient and multivariable regression modeling.

Results

Cervical ultrasound correctly predicted adenoma laterality in 95.5%, sestamibi scintigraphy in 80.6%, both had lower true-positive rates for quadrant prediction. Patients with negative imaging results showed higher thyroid volumes than those with positive results. Adenoma volume was positively correlated with preoperative PTH (p < 0.001) and calcium (p < 0.001) and negatively correlated with preoperative phosphate (p = 0.001). Using these preoperative biochemical markers and patient age and BMI, adenoma volume can be significantly predicted using the multivariable regression algorithm.

Conclusion

Cervical ultrasound is superior to scintigraphy for predicting adenoma location and should be the first-choice imaging method, but both methods may be limited by increased thyroid volume. Large adenomas are more likely with higher PTH, higher calcium, and lower phosphate levels. In cases of undetermined adenoma location, an estimation of adenoma volume via our algorithm could corroborate sonographic volume measurements of the suspected adenoma.
Effect of Specimen Placement on Model Rock Blasting
Authors: Zhang Zong-Xian , Chi Li Yuan , Zhang Qingbin
Published: April 2021

Small-scale model blasting plays an important role in understanding mechanism of rock fragmentation by blasting and improving blast technology in rock and mining engineering. Because a specimen (or model) often needs to be placed on either a ground or another material in model blasting, an additional interface appears between the specimen and the ground (or material), compared with an engineering blast that does not have such an interface. In this paper, four model blasts with high-speed photography were presented. The results showed that: (1) as the impedance of a rock specimen was smaller than that of the ground material, the specimen was thrown up and a certain amount of kinetic energy was brought with such a bounce. Thus, this placement should be avoided in model blasts. (2) As a rock specimen was placed on three blocks of the same type of rock as the specimen the specimen was not bounced up during blasting. Correspondingly, no kinetic energy was induced by specimen bounce. Therefore, this placement is recommended for model blasting. If very high specific charge must be used in model blasting, the above-recommended method will not work well due to possible breakage of the base material during blasting. In this case, the rock specimen can be placed on a material with smaller impedance than that of the rock specimen so that specimen bounce can be reduced. Accordingly, such a possible specimen bounce should be estimated by stress wave analysis.
Electrochemical deposition of nickel targets from aqueous electrolytes for medical radioisotope production in accelerators: a review
Authors: Mieszkowska M. , Grdeń M.
Published: April 2021

This paper reviews reported methods of the electrochemical deposition of nickel layers which are used as target materials for accelerator production of medical radioisotopes. The review focuses on the electrodeposition carried out from aqueous electrolytes. It describes the main challenges related to the preparation of suitable Ni target layers, such as work with limited amounts of expensive isotopically enriched nickel; electrodeposition of sufficiently thick, smooth and free of cracks layers; and recovery of unreacted Ni isotopes from the irradiated targets and from used electrolytic baths.
Clinical features and risk factors of Raynaud’s phenomenon in primary Sjögren’s syndrome
Authors: Lin Wei , Xin Zhifei , Ning Xiaoran , Li Yang , Ren Xiuying , Su Yashuang , Liu Meilu , Guo Shaoying , Yang Liu , Liu Yixuan , Zhang Fengxiao , Zhang Wen
Published: April 2021

Objective

The aim at the current study was to investigate the clinical characteristics and risk factors of Raynaud’s phenomenon (RP) in patients with primary Sjögren’s syndrome (pSS).

Methods

Retrospective analysis of the medical records of 333 new-onset pSS patients was performed. Demographic, clinical, and serological data were compared between individuals with and without RP. Logistic regression analysis was used to identify risk factors.

Results

RP was present in 11.41% of the pSS patients. pSS-RP patients were younger (49.74±14.56 years vs. 54.46±13.20 years, p=0.04) and exhibited higher disease activity (11 [5.75–15] vs. 7 [4–12], p=0.03) than those without. The prevalence of lung involvement was significantly higher in pSS patients with RP (60.53% vs. 17.29%; p<0.001). A significantly higher proportion of patients with pSS-RP tested positive about antinuclear (ANA), anti-RNP, and anti-centromere antibodies (ACA) compared to those without (p=0.003, <0.001, and 0.01, respectively). Multivariate analysis identified lung involvement (odds ratio [OR]=8.81, 95% confidence interval [CI] 2.02–38.47; p=0.04), anti-RNP positive status (OR=79.41, 95% CI 12.57–501.78; p<0.0001), as well as ACA (OR=13.17, 95% CI 2.60–66.72; p=0.002) as prognostic factors for pSS-RP.

Conclusion

The presence of RP defined a subset of pSS with a unique phenotype, manifesting as increased lung involvement and a higher frequency of anti-RNP antibodies and ACA, as well as greater disease activity. These results suggest that RP has clinical and prognostic value of pSS patients. Further prospective studies with a larger number of subjects are warranted to confirm our findings and assess the prognostic and treatment implications of RP in pSS patients.

Key Points• Raynaud’s phenomenon (RP) was present in 38 (11.41%) of 333 patients with primary Sjögren’s syndrome (pSS), with patients with RP exhibiting a younger age and higher disease activity.• The presence of RP indicates a subset of pSS with a unique phenotype, with manifestations including increased lung involvement and a higher frequency of anti-RNP antibodies and anti-centromere antibodies.• Patients with pSS and RP need close follow-up and long-term observation (including assessment of microangiopathy), with specific attention paid to the possible development of clinical features of systemic sclerosis.
Safe from what? Understanding environmental non-migration in Chilean Patagonia through ontological security and risk perceptions
Authors: Wiegel Hanne , Warner Jeroen , Boas Ingrid , Lamers Machiel
Published: April 2021

Why do communities prefer to stay in place despite potentially dangerous changes in their environment, even when governmental support for outmigration or resettlement is provided? That is the key question this paper seeks to answer. Voluntary immobility is a burgeoning research topic in environmental change-related migration studies, although the role of local sense-making of perceived risks and migration pressures has received only little attention. In order to examine decisions for non-migration, we argue that we need to consider people’s ontological security, or subjective sense of existential safety, which shapes risk perceptions. We apply this to the case of Villa Santa Lucía in Chilean Patagonia, where the local population has rejected relocation policies after the village was severely damaged by a mudslide in December 2017. We show how this rejection is not based on the lack of abilities to move, but on a fundamentally different risk assessment grounded in locally specific social representations of nature and human-nature relations. This alternative understanding of environmental risks allows the local population to uphold their sense of ontological security while remaining in Villa Santa Lucía, and renders relocation to avoid exposure to natural hazards futile or even inconsistent with local identities. We conclude that local sense-making of environmental risks is an important component of a more fine-grained understanding of environmental non-migration decisions.
How to Draw the Line Between Health and Disease? Start with Suffering
Authors: Hofmann Bjørn
Published: April 2021

How can we draw the line between health and disease? This crucial question of demarcation has immense practical implications and has troubled scholars for ages. The question will be addressed in three steps. First, I will present an important contribution by Rogers and Walker who argue forcefully that no line can be drawn between health and disease. However, a closer analysis of their argument reveals that a line-drawing problem for disease-related features does not necessarily imply a line-drawing problem for disease as such. The second step analyzes some alternative approaches to drawing the line between health and disease. While these approaches do not provide full answers to the question, they indicate that the line-drawing question should not be dismissed too hastily. The third step investigates whether the line-drawing problem can find its solution in the concept of suffering. In particular, I investigate whether returning to the origin of medicine, with the primary and ultimate goal of reducing suffering, may provide sources of demarcation between health and disease. In fact, the reason why we pay attention to particular phenomena as characteristics of disease, consider certain processes to be relevant, and specific functions are classified as dys-functions, is that they are related to suffering. Accordingly, using suffering as a criterion of demarcation between health and disease may hinder a wide range of challenges with modern medicine, such as unwarranted expansion of disease, overdiagnosis, overtreatment, and medicalization.
Arithmetic properties of polynomial solutions of the Diophantine equation $$P(x)x^{n+1}+Q(x)(x+1)^{n+1}=1$$
Authors: Dilcher Karl , Ulas Maciej
Published: April 2021

For each integer$$n\ge 1$$n≥1we consider the unique polynomials$$P, Q\in {\mathbb {Q}}[x]$$P,Q∈Q[x]of smallest degreenthat are solutions of the equation$$P(x)x^{n+1}+Q(x)(x+1)^{n+1}=1$$P(x)xn+1+Q(x)(x+1)n+1=1. We derive numerous properties of these polynomials and their derivatives, including explicit expansions, differential equations, recurrence relations, generating functions, resultants, discriminants, and irreducibility results. We also consider some related polynomials and their properties.
Investigation of the uptake of molybdenum by plants from Argentinean groundwater
Authors: Lawson-Wood Kathryn , Jaafar Maisarah , Felipe-Sotelo Mónica , Ward Neil I.
Published: April 2021

Some regions of Argentina are affected by high concentrations of molybdenum, arsenic and vanadium from natural sources in their groundwater. In particular, Mo levels in groundwater from Eduardo Castex (La Pampa, Argentina) typically exceed the guidelines for drinking water formerly established by WHO at 70 μg/L. Therefore, this study investigated the uptake of Mo in plants, using cress (Lepidium sativum L.) as a model using hydroponic experiments with synthetic solutions and groundwater from La Pampa. Cress grown from control experiments (150 μg/L Mo, pH 7) presented an average Mo concentration of 35.2 mg/kg (dry weight, d.w.), higher than the typical total plant range (0.7–2.5 mg/kg d.w.) in the literature. Using pooled groundwater samples (65.0–92.5 μg/L Mo) from wells of La Pampa (Argentina) as growth solutions resulted in significantly lower cress Mo levels (1.89–4.59 mg/kg d.w.) than were obtained for synthetic solutions of equivalent Mo concentration. This may be due to the high levels in these groundwater samples of As, V, Fe and Mn which are known to be associated with volcanic deposits. This research addressed the hitherto scarcity of data about the effect of various physicochemical parameters on the uptake of Mo in plants.
Dynamically complete markets under Brownian motion
Authors: Diasakos Theodoros M.
Published: April 2021

This paper investigates how continuous-time trading renders complete a financial market in which the underlying risk process is a Brownian motion. A sufficient condition, that the instantaneous dispersion matrix of the relative dividends is non-degenerate, has been established in the literature for single-commodity, pure-exchange economies with many heterogenous agents where the securities’ dividends as well as the agents’ utilities and endowments include flows during the trading horizon which are analytic functions. In sharp contrast, the present analysis is based upon a different mathematical argument that assumes neither analyticity nor a particular underlying economic environment. The novelty of our approach lies in deriving closed-form expressions for the dispersion coefficients of the securities’ prices. To this end, we assume only that the pricing kernels and dividends satisfy standard growth and smoothness restrictions (mild enough to allow even for options). In this sense, our sufficiency conditions apply irrespectively of preferences, endowments or other structural elements (for instance, whether or not the budget constraints include only pure exchange).
Continuous size fractionation of magnetic nanoparticles by using simulated moving bed chromatography
Authors: Arlt Carsten-Rene , Brekel Dominik , Neumann Stefan , Rafaja David , Franzreb Matthias
Published: April 2021

The size fractionation of magnetic nanoparticles is a technical problem, which until today can only be solved with great effort. Nevertheless, there is an important demand for nanoparticles with sharp size distributions, for example for medical technology or sensor technology. Using magnetic chromatography, we show a promising method for fractionation of magnetic nanoparticles with respect to their size and/or magnetic properties. This was achieved by passing magnetic nanoparticles through a packed bed of fine steel spheres with which they interact magnetically because single domain ferro-/ferrimagnetic nanoparticles show a spontaneous magnetization. Since the strength of this interaction is related to particle size, the principle is suitable for size fractionation. This concept was transferred into a continuous process in this work using a so-called simulated moving bed chromatography. Applying a suspension of magnetic nanoparticles within a size range from 20 to 120 nm, the process showed a separation sharpness of up to 0.52 with recovery rates of 100%. The continuous feed stream of magnetic nanoparticles could be fractionated with a space-time-yield of up to 5 mg/(L∙min). Due to the easy scalability of continuous chromatography, the process is a promising approach for the efficient fractionation of industrially relevant amounts of magnetic nanoparticles.
Load Forecasting Based on LSTM Neural Network and Applicable to Loads of “Replacement of Coal with Electricity”
Authors: Chen Zexi , Zhang Delong , Jiang Haoran , Wang Longze , Chen Yongcong , Xiao Yang , Liu Jinxin , Zhang Yan , Li Meicheng
Published: April 2021

With the complete implementation of the “Replacement of Coal with Electricity” policy, electric loads borne by urban power systems have achieved explosive growth. The traditional load forecasting method based on “similar days” only applies to the power systems with stable load levels and fails to show adequate accuracy. Therefore, a novel load forecasting approach based on long short-term memory (LSTM) was proposed in this paper. The structure of LSTM and the procedure are introduced firstly. The following factors have been fully considered in this model: time-series characteristics of electric loads; weather, temperature, and wind force. In addition, an experimental verification was performed for “Replacement of Coal with Electricity” data. The accuracy of load forecasting was elevated from 83.2 to 95%. The results indicate that the model promptly and accurately reveals the load capacity of grid power systems in the real application, which has proved instrumental to early warning and emergency management of power system faults.
Integrated Commonsense Reasoning and Deep Learning for Transparent Decision Making in Robotics
Authors: Mota Tiago , Sridharan Mohan , Leonardis Aleš
Published: April 2021

A robot’s ability to provide explanatory descriptions of its decisions and beliefs promotes effective collaboration with humans. Providing the desired transparency in decision making is challenging in integrated robot systems that include knowledge-based reasoning methods and data-driven learning methods. As a step towards addressing this challenge, our architecture combines the complementary strengths of non-monotonic logical reasoning with incomplete commonsense domain knowledge, deep learning, and inductive learning. During reasoning and learning, the architecture enables a robot to provide on-demand explanations of its decisions, the evolution of associated beliefs, and the outcomes of hypothetical actions, in the form of relational descriptions of relevant domain objects, attributes, and actions. The architecture’s capabilities are illustrated and evaluated in the context of scene understanding tasks and planning tasks performed using simulated images and images from a physical robot manipulating tabletop objects. Experimental results indicate the ability to reliably acquire and merge new information about the domain in the form of constraints, preconditions, and effects of actions, and to provide accurate explanations in the presence of noisy sensing and actuation.
Modulatory effect of olanzapine on SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expressions in the rat brainstem
Authors: Pałasz Artur , Żarczyński Piotr , Bogus Katarzyna , Mordecka-Chamera Kinga , Della Vecchia Alessandra , Skałbania Jakub , Worthington John J. , Krzystanek Marek , Żarczyńska Małgorzata
Published: April 2021

Background

Phoenixin, spexin and nesfatin-1 belong to a family of newly discovered multifunctional neuropeptides that play regulatory roles in several brain structures and modulate the activity of important neural networks. However, little is known about their expression and action at the level of brainstem. The present work was, therefore, focused on gene expression of the aforementioned peptides in the brainstem of rats chronically treated with olanzapine, a second generation antipsychotic drug.

Methods

Studies were carried out on adult, male Sprague–Dawley rats that were divided into 2 groups: control and experimental animals treated with olanzapine (28-day-long intraperitoneal injection, at dose 5 mg/kg daily). All individuals were killed under anesthesia and the brainstem excised. Total mRNA was isolated from homogenized samples of both structures and the RT-PCR method was used for estimation of related SMIM20/phoenixin, NPQ/spexin and NUCB2/nesfatin-1 gene expression.

Results

Long-term treatment with olanzapine is reflected in qualitatively different changes in expression of examined neuropeptides mRNA in the rat brainstem. Olanzapine significantly decreased NPQ/spexin mRNA expression, but increased SMIM20/phoenixin mRNA level in the rat brainstem; while NUCB2/nesfatin-1 mRNA expression remained unchanged.

Conclusions

Olanzapine can affect novel peptidergic signaling in the rat brainstem. This may cautiously suggest the presence of an alternative mode of its action.
Enhancement of light aircraft 6 DOF simulation using flight test data in longitudinal motion
Authors: Nguyen L.V.T. , Tyan M. , Lee J.-W. , Kim S.
Published: April 2021

This paper proposes a procedure to improve the accuracy of the light aircraft 6 DOF simulation model by implementing model tuning and aerodynamic database correction using flight test data. In this study, the full-scale flight testing of a 2-seater aircraft has been performed in specific longitudinal manoeuver for model enhancement and simulation validation purposes. The baseline simulation model database is constructed using multi-fidelity analysis methods such as wind tunnel (W/T) test, computational fluid dynamic (CFD) and empirical calculation. The enhancement process starts with identifying longitudinal equations of motion for sensitivity analysis, where the effect of crucial parameters is analysed and then adjusted using the model tuning technique. Next, the classical Maximum Likelihood (ML) estimation method is applied to calculate aerodynamic derivatives from flight test data, these parameters are utilised to correct the initial aerodynamic table. A simulation validation process is introduced to evaluate the accuracy of the enhanced 6 DOF simulation model. The presented results demonstrate that the applied enhancement procedure has improved the simulation accuracy in longitudinal motion. The discrepancy between the simulation and flight test response showed significant improvement, which satisfies the regulation tolerance.
Law and Development Minus Legal Transplants: The Example of China in Vietnam
Authors: Erie Matthew S. , Hai Ha Do
Published: April 2021

Legal transplants are broadly recognized as one of the main mechanisms by which donor states influence the legal development of recipient states. The experience of China, however, challenges convention. While, in recent years, China has been one of the largest capital-exporting countries in the world and has mobilized law to protect its investment in high-risk recipient states, legal transplants have, to date, not played a major role in China’s approach to law and development. This article examines this puzzle through the case of China’s participation in formulating Vietnam’s 2018 SEZ Bill. In doing so, this article sets forth a number of hypotheses as to why Chinese law has thus far not assumed the form of legal transplant. The example of the SEZ Bill demonstrates how Chinese legal transplants depend as much on the “pull” of recipient states as they do on the “push” of the donor. The case-study of the SEZ Bill raises important questions not only for Chinese law and development, but also, more generally, for the viability of “second-order” legal transplants: those from an Asian donor to an Asian recipient.
Impact of the COVID-19 pandemic on patients with pre-existing mood disorders
Authors: McLoughlin James , O’Grady Margaret M. , Hallahan Brian
Published: April 2021

Objectives:

To examine the psychological and social impact of the COVID-19 pandemic on patients with established mood disorders during a period of stringent mandated social restrictions.

Methods:

Semi-structured interviews were conducted with 36 individuals attending the Galway–Roscommon Mental Health Services with an International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10) diagnosis of either Bipolar Affective Disorder (BPAD) (n = 20) or Emotionally Unstable Personality Disorder (EUPD) (n = 16) in this cross-sectional study. We determined the impact of the COVID-19 restrictions on anxiety and depressive symptoms, impulsivity, thoughts of self-harm, social and occupational functioning and quality of life.

Results:

The COVID-19 pandemic deleteriously impacted mental health (56.3% v. 15.0%, χ2 = 7.42, p = 0.02), and mood (75.0% v. 20.0%, χ2 = 11.17, p = 0.002) to a greater extent in the EUPD compared to the bipolar disorder cohort, with 43.8% of individuals with EUPD reporting an increase in suicidal ideation. Psychometric rating scales [Beck Anxiety Inventory (BAI), Beck Depression Scale (BDS), Beck Hopelessness Scale (BHS), Barratt Impulsivity Scale (BIS)] and Likert scales for anxiety, mood and quality of life noted significantly higher levels of psychopathology in the EUPD cohort (p < 0.01). Qualitative analysis reflected quantitative data with themes of the employment of maladaptive coping mechanisms and reduced mental health supports notable.

Conclusions:

Individuals with EUPD are experiencing significant mental health difficulties related to the COVID-19 pandemic. The provision and recommencement of therapeutic interventions to this cohort, in particular, are warranted given the significant distress and symptoms being experienced.
Concealing Conflict Markets: How Rebels and Firms Use State Institutions to Launder Wartime Trade
Authors: Sweet Rachel
Published: April 2021

Although rebel groups are players on the international stage, little is known about their financial strategies at this scale. Existing research suggests that rebels succeed in cross-border trade by using informal networks that evade state authority. Yet rebels face a critical challenge: they operate in a normative environment that values state recognition and penalizes their illegitimate status. New evidence reveals that rebels can overcome this barrier and better connect to global economies not by evading the state but by infiltrating its institutions. Drawing on unprecedented data—the internal records of armed groups and their trading partners—I examine how rebels use state agencies in conflict zones to manufacture a legal cover for wartime trade. By using state agencies to provide false certification, rebels can place the stamp of state on their trade deals. This strategy of legal appropriation is a fundamentally different model of how conflict markets skirt sanctions and connect to global buyers. I develop a framework for how this strategy works that traces how international sovereignty norms and sanctions regimes create incentives for rebels, firms, and bureaucrats to coordinate around this legal veneer across the supply chain. The framework and evidence contribute theoretical and policy understandings for rebel governance, state building and fragmentation, and illicit global markets.
Variations in funding for treatment of obstructive sleep apnoea in England
Authors: Chaidas K , Ashman A
Published: April 2021

Objectives

This study aimed to review the funding policies of clinical commissioning groups for treatment of obstructive sleep apnoea in England.

Methods

Published policies from a randomly selected sample of 60 out of 190 clinical commissioning groups were reviewed.

Results

Continuous positive airway pressure was funded based on a clinical assessment or according to criteria that were in line with national guidelines in most clinical commissioning groups (49 of 60), with 11 clinical commissioning groups offering no policy. Mandibular advancement devices, tonsillectomy and nasal surgery were funded based on a clinical assessment or certain criteria in 16, 25 and 16 clinical commissioning groups, respectively. In contrast, only one clinical commissioning group provided funding for soft palate, tongue base or mandibular surgery. Hypoglossal nerve stimulation was not mentioned in any clinical commissioning group's policy.

Conclusion

Although most clinical commissioning groups provide funding for the use of continuous positive airway pressure, the availability of funding for other obstructive sleep apnoea treatment modalities is heterogeneous, leaving continuous positive airway pressure intolerant patients with limited therapeutic options in some regions.
Medical Ethics, Malpractice, and Emergency Medical Services: Some Congressional Concerns
Authors: Rogers Paul G.
Published: April 2021

Today, it is readily apparent that the legal and moral aspects of medical practice are becoming increasingly complex. This is not to say that the practitioners of, say, twenty years ago did not face complex legal and ethical questions. Certainly they did. But for them, such questions were not raised in such diverse ways as they are today.
The Ties That Bind: Life Care Contracts and Nursing Homes
Authors: Leonard Lawrence R.
Published: April 2021

Approximately 1.3 million of our nation's elderly live in nursing homes. Despite the increasingly important role of Medicare and Medicaid, many must bear the costs of their care. This Note examines one means of financing nursing home care—the life care contract. These require residents to pay an entrance fee and transfer to the nursing home all or part of their property in return for the home's promise to provide care for the remainder of the resident's life. The Note discusses the potential problems a life care resident may face, such as substandard living conditions or a home's financial instability. It concludes by delineating steps that potential residents can take in constructing life care contracts to ensure protection of their rights and needs.
Controlling Post-transfusion Hepatitis: A Proposal to Publicize Hepatitis Rates of Transfusion Facilities
Authors: Finkelstein Stan N. , Sapolsky Harvey M.
Published: April 2021

A federal requirement that donor blood be labelled as either “paid” or “volunteer” took effect on May 15, 1978. A major rationale for requiring such labelling is that physicians, now that they can distinguish between categories of blood, will fear liability for post-transfusion hepatitis resulting from the use of paid blood. Thus, supporters of the labelling requirement hope that it will deter the use of high-risk commercial blood. Some paid blood, however, is not commercial blood and in fact may be safer than volunteer blood. The labelling strategy for hepatitis control, therefore, has negative as well as positive attributes. This Article considers the efficacy of blood labelling as a hepatitis control measure and proposes an alternative strategy—the periodic publicizing of hepatitis rates of facilities that perform transfusions—that, if practiced responsibly, could significantly decrease hepatitis transmission rates.
Poppies, Ropes, and Shadow Play: Transcultural Memories of the First World War during Brexit
Authors: Sörgel Sabine
Published: April 2021

The years 2014 to 2018 witnessed the centenary of the First World War, commemorated around different cities and other locations around the world. In the United Kingdom, public centenary commemorations were funded by the Tory government, Heritage Lottery Fund, and private and corporate donors with an overall budget of over fifty million pounds, including the cultural programme 14–18 NOW that encompassed television documentaries, educational programmes, art exhibitions, theatre, and dance performances. 2016 was also the year of the divisive Brexit referendum, when Leave voters won by a small margin to end Britain’s membership of the European Union. As Britain sought to redefine its global political role, artists devised a set of suggestive transcultural acts of remembrance to spur public debate about the colonial past and current resurging nationalism. This article discusses three important theatrical events commissioned by 14–18 NOW: Paul Cummins and Tom Piper’s Blood Swept Lands and Seas of Red (2014), Akram Khan’s XENOS (2018), and William Kentridge’s The Head & the Load (2018). Each theatrical event refocused awareness regarding long-standing crises of identity conflicts at the heart of Britain’s contemporary politics, pointing towards an uncertain national future. Sabine Sörgel was Senior Lecturer in Dance and Theatre at the University of Surrey (2013–2019) and is now an independent scholar, writer, and dramaturge. Her most recent book is African Contemporary Dance Theatre: Phenomenology, Whiteness, and the Gaze (Palgrave Macmillan, 2020).
Imaging radar for automated driving functions
Authors: Iqbal Hasan , Löffler Andreas , Mejdoub Mohamed Nour , Zimmermann Daniel , Gruson Frank
Published: April 2021

This work presents the implementation of a synthetic aperture radar (SAR) at 77 GHz, for automotive applications. This implementation is unique in the sense that it is a radar-only solution for most use-cases. The set-up consists of two radar sensors, one to calculate the ego trajectory and the second for SAR measurements. Thus the need for expensive GNSS-based dead reckoning systems, which are in any case not accurate enough to fulfill the requirements for SAR, is eliminated. The results presented here have been obtained from a SAR implementation which is able to deliver processed images in a matter of seconds from the point where the targets were measured. This has been accomplished using radar sensors which will be commercially available in the near future. Hence the results are easily reproducible since the deployed radars are not special research prototypes. The successful widespread use of SAR in the automotive industry will be a large step forward toward developing automated parking functions which will be far superior to today's systems based on ultrasound sensors and radar (short range) beam-forming algorithms. The same short-range radar can be used for SAR, and the ultrasound sensors can thus be completely omitted from the vehicle.
Toward the Pursuit of What People Value
Authors: Teng-Calleja Mendiola , R. Clemente Jose Antonio , Menguito Ma. Ligaya , Bertulfo Donald Jay
Published: April 2021

Abstract. This study sought to initiate conversations on the utility of the capability approach and a psychological lens in approximating a living wage. We put forth the concept of capability gap – defined as the difference between what one values and what one perceives as attainable. We used a set of valued domains of a good life that were identified based on well-being indicators in determining capability gaps. Five hundred workers (all breadwinners) belonging to households selected through stratified random sampling from purposively chosen middle- and low-income communities in the Philippines participated in the survey. From the data, we constructed a weighted capability measure that determines the capability gap, weighted by the perceived importance of each of the good life domains. We likewise derived an estimate of a living wage that yields a weighted capability that represents individuals' capabilities to achieve and pursue valued outcomes, freedoms, and entitlements. This initial attempt at estimating a living wage based on individuals' capability to achieve and pursue a good life is presented as the main contribution of the research. The limitations of the study as well as its implications to living wage research and policy are discussed.
Assessing the Impacts of Recent Crop Expansion on Water Quality in the Missouri River Basin Using the Soil and Water Assessment Tool
Authors: Chen Pan , Yuan Yongping , Li Wenhong , LeDuc Stephen D. , Lark Tyler J. , Zhang Xuesong , Clark Christopher
Published: April 2021

The Missouri River Basin (MORB) has experienced a resurgence of grassland conversion to crop production, which raised concerns on water quality. We applied the Soil and Water Assessment Tool (SWAT) to address how this conversion would impact water quality. We designed three crop production scenarios representing conversion of grassland to: (a) continuous corn; (b) corn/soybean rotation; and (c) corn/wheat rotation to assess the impact. The SWAT model results showed: (a) the lower MORB produced high total nitrogen (TN) and total phosphorus (TP) load before conversion (baseline) due mainly to high precipitation and high agricultural activity; (b) the greatest percentage increases of TN and TP occurred in the North and South Dakotas, coinciding with the highest amount of grassland conversion to cropland; and (c) grassland conversion to continuous corn resulted in the greatest increase in TN and TP loads, followed by conversion to corn/soybean and then conversion to corn/wheat. Although the greatest percentage increases of TN and TP occurred in the North and South Dakotas, these areas still contributed relatively low TN and TP to total basin loads after conversion. However, watersheds, predominantly in the lower MORB continued to be “hotspots” that contributed the greatest amounts of TN and TP to the total basin loads—driven by a combination of grassland conversion, high precipitation, and loading from pre‐existing cropland. At the watershed outlet, the TN and TP loads were increased by 6.4% (13,800 t/yr) and 8.7% (3,400 t/yr), respectively, during the 2008–2016 period for the conversion to continuous corn scenario.
A Comparison of Six Transport Models of the MADE‐1 Experiment Implemented With Different Types of Hydraulic Data
Authors: Zech Alraune , Attinger Sabine , Bellin Alberto , Cvetkovic Vladimir , Dagan Gedeon , Dentz Marco , Dietrich Peter , Fiori Aldo , Teutsch Georg
Published: April 2021

Six conceptually different transport models were applied to the macrodispersion experiment (MADE)‐1 field tracer experiment as a first major attempt for model comparison. The objective was to show that complex mass distributions in heterogeneous aquifers can be predicted without calibration of transport parameters, solely making use of structural and flow data. The models differ in their conceptualization of the heterogeneous aquifer structure, computational complexity, and use of conductivity data obtained from various observation methods (direct push injection logging, DPIL, grain size analysis, pumping tests and flowmeter). They share the same underlying physical transport process of advection by the velocity field solely. Predictive capability is assessed by comparing results to observed longitudinal mass distributions of the MADE‐1 experiment. The decreasing mass recovery of the observed plume is attributed to sampling and no physical process like mass transfer is invoked by the models. Measures like peak location and strength are used in comparing the modeled and measured plume mass distribution. Comparison of models reveals that the predictions of the solute plume agree reasonably well with observations, if the models are underlain by a few parameters of close values: mean velocity, a parameter reflecting log‐conductivity variability, and a horizontal length scale related to conductivity spatial correlation. The robustness of the results implies that conservative transport models with appropriate conductivity upscaling strategies of various observation data provide reasonable predictions of plumes longitudinal mass distribution, as long as key features are taken into account.
HMGA1B/2 transcriptionally activated-POU1F1 facilitates gastric carcinoma metastasis via CXCL12/CXCR4 axis-mediated macrophage polarization
Authors: Tang Cheng , Lei Xiong , Xiong Lingqiang , Hu Zhigao , Tang Bo
Published: April 2021

Tumor-associated macrophages (TAMs) in the tumor microenvironment contribute to poor prognosis in gastric cancer (GC). However, the underlying mechanism by which TAMs promote GC progression and metastasis remains elusive. Expression of POU1F1 was detected in 60 matched GC-normal tissue pairs using qRT-PCR and immunohistochemistry (IHC) analysis. The correlation between POU1F1 and the clinical-pathological factors of GC patients were further assessed. Cell proliferation was monitored by CCK-8, colony formation, and 5-Ethynyl-2’-deoxyuridine (EdU) incorporation assays. Cell migration and invasion were assessed by transwell assays. The impact on angiogenesis was evaluated by tube formation assay. Xenograft model was generated to investigate the role of POU1F1 on tumor growth and lung metastasis in vivo. GST pull-down and Co-immunoprecipitation (Co-IP) were used to study the interaction between HMGA1B/2 and POU1F1. Chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were performed to investigate the transcriptional regulation of POU1F1. Flow cytometry was performed to detect the surface expression of macrophage markers. Upregulated POU1F1 observed both in GC tissues and cell lines was positively correlated with poor prognosis. Knockdown of POU1F1 inhibited cell proliferation, migration, invasion, and angiogenesis in vitro, and suppressed tumor growth in vivo. HMGA1B/2 transcriptionally activated-POU1F1. POU1F1 promoted GC progression via regulating macrophage proliferation, migration, polarization, and angiogenesis in a CXCL12/CXCR4-dependent manner. POU1F1 also promoted GC metastasis in lung by modulating macrophage polarization through CXCL12/CXCR4 axis in vivo. HMGA1B/2-upregulated POU1F1 promoted GC metastasis via regulating macrophage polarization in a CXCL12/CXCR4-dependent manner.
Role of 3D quantitative tumor analysis for predicting overall survival after conventional chemoembolization of intrahepatic cholangiocarcinoma
Authors: Rexha Irvin , Laage-Gaupp Fabian , Chapiro Julius , Miszczuk Milena Anna , van Breugel Johanna Maria Mijntje , Lin MingDe , Konstantinidis Menelaos , Duran Rafael , Gebauer Bernhard , Georgiades Christos , Hong Kelvin , Nezami Nariman
Published: April 2021

This study was designed to assess 3D vs. 1D and 2D quantitative tumor analysis for prediction of overall survival (OS) in patients with Intrahepatic Cholangiocarcinoma (ICC) who underwent conventional transarterial chemoembolization (cTACE). 73 ICC patients who underwent cTACE were included in this retrospective analysis between Oct 2001 and Feb 2015. The overall and enhancing tumor diameters and the maximum cross-sectional and enhancing tumor areas were measured on baseline images. 3D quantitative tumor analysis was used to assess total tumor volume (TTV), enhancing tumor volume (ETV), and enhancing tumor burden (ETB) (ratio between ETV and liver volume). Patients were divided into low (LTB) and high tumor burden (HTB) groups. There was a significant separation between survival curves of the LTB and HTB groups using enhancing tumor diameter (p = 0.003), enhancing tumor area (p = 0.03), TTV (p = 0.03), and ETV (p = 0.01). Multivariate analysis showed a hazard ratio of 0.46 (95%CI: 0.27–0.78, p = 0.004) for enhancing tumor diameter, 0.56 (95% CI 0.33–0.96, p = 0.04) for enhancing tumor area, 0.58 (95%CI: 0.34–0.98, p = 0.04) for TTV, and 0.52 (95%CI: 0.30–0.91, p = 0.02) for ETV. TTV and ETV, as well as the largest enhancing tumor diameter and maximum enhancing tumor area, reliably predict the OS of patients with ICC after cTACE and could identify ICC patients who are most likely to benefit from cTACE.
U-survival for prognostic prediction of disease progression and mortality of patients with COVID-19
Authors: Näppi Janne J. , Uemura Tomoki , Watari Chinatsu , Hironaka Toru , Kamiya Tohru , Yoshida Hiroyuki
Published: April 2021

The rapid increase of patients with coronavirus disease 2019 (COVID-19) has introduced major challenges to healthcare services worldwide. Therefore, fast and accurate clinical assessment of COVID-19 progression and mortality is vital for the management of COVID-19 patients. We developed an automated image-based survival prediction model, called U-survival, which combines deep learning of chest CT images with the established survival analysis methodology of an elastic-net Cox survival model. In an evaluation of 383 COVID-19 positive patients from two hospitals, the prognostic bootstrap prediction performance of U-survival was significantly higher (P < 0.0001) than those of existing laboratory and image-based reference predictors both for COVID-19 progression (maximum concordance index: 91.6% [95% confidence interval 91.5, 91.7]) and for mortality (88.7% [88.6, 88.9]), and the separation between the Kaplan–Meier survival curves of patients stratified into low- and high-risk groups was largest for U-survival (P < 3 × 10–14). The results indicate that U-survival can be used to provide automated and objective prognostic predictions for the management of COVID-19 patients.
Anthropogenic nitrate in groundwater and its health risks in the view of background concentration in a semi arid area of Rajasthan, India
Authors: Rahman Abdur , Mondal N. C. , Tiwari K. K.
Published: April 2021

An increased nitrate (NO3−) concentration in groundwater has been a rising issue on a global scale in recent years. Different consumption mechanisms clearly illustrate the adverse effects on human health. The goal of this present study is to assess the natural and anthropogenic NO3− concentrations in groundwater in a semi arid area of Rajasthan and its related risks to human health in the different groups of ages such as children, males, and females. We have found that most of the samples (n = 90) were influenced by anthropogenic activities. The background level of NO3− had been estimated as 7.2 mg/L using a probabilistic approach. About 93% of nitrate samples exceeded the background limit, while 28% of the samples were beyond the permissible limit of 45 mg/L as per the BIS limits. The results show that the oral exposure of nitrate was very high as compare to dermal contact. With regard to the non-carcinogenic health risk, the total Hazard Index (HITotal) values of groundwater nitrate were an average of 0.895 for males, 1.058 for females, and 1.214 for children. The nitrate health risk assessment shows that about 38%, 46%, and 49% of the samples constitute the non-carcinogenic health risk to males, females, and children, respectively. Children were found to be more prone to health risks due to the potential exposure to groundwater nitrate.