bluuebunny/crossref_metadata_2025 huggingface dataset:
An Increased Lateral Femoral Condyle Ratio Is a Risk Factor for Anterior Cruciate Ligament Injury
Authors: Pfeiffer Thomas R. , Burnham Jeremy M. , Hughes Jonathan D. , Kanakamedala Ajay C. , Herbst Elmar , Popchak Adam , Shafizadeh Sven , Irrgang James J. , Debski Richard E. , Musahl Volker
Published: May 2018

Background:

The purpose of this study was to examine the relationship between distal femoral morphology and anterior cruciate ligament (ACL) injury, ACL reconstruction (ACLR) failure, and contralateral ACL injury. It was hypothesized that increased posterior femoral condylar depth, quantified as the lateral femoral condyle ratio, would correlate with increased risk of primary ACL injuries, ACLR failures, and contralateral ACL injuries.

Methods:

The charts of consecutive patients who underwent arthroscopic knee surgery at an academic medical center from 2012 to 2016 with minimum follow-up of 24 months were retrospectively reviewed. Patients were stratified into 4 groups: (1) a control group of patients with no ACL injury, (2) patients with primary ACL injury, (3) patients with failed ACLR, and (4) patients with previous ACL injury and subsequent contralateral ACL injury. With use of lateral radiographs, the ratio of posterior femoral condylar depth to total condylar length was defined as the lateral femoral condyle ratio. Differences between study groups were identified with use of analysis-of-variance (ANOVA) and post-hoc testing with significance set at p < 0.05. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal cutoff for detecting increased risk of ACL injury.

Results:

Two hundred patients met the inclusion criteria. The mean lateral femoral condyle ratios (and standard deviations) were 61.2% ± 2.4% in the control group, 64.2% ± 3.8% in the primary ACL injury group, 64.4% ± 3.6% in the failed ACLR group, and 66.9% ± 4.3% in the contralateral ACL injury group. Patients who had a primary ACL injury, failed ACLR, or contralateral ACL injury had significantly higher ratios compared with the control group (p < 0.008). ROC curve analysis demonstrated that a lateral femoral condyle ratio of >63% was associated with an increased risk for ACL injury, with a sensitivity of 77% and a specificity of 72%.

Conclusions:

The data from this study show that increased posterior femoral condylar depth, quantified as the lateral femoral condyle ratio, is associated with an increased risk of ACL injury, including primary and contralateral ACL injuries. The data from this study may help clinicians to identify patients at a greater risk of ACL injury.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Improving the Ability in Writing Narrative Text of Junior High School Students through Peer Feedback
Authors: Noor Mochammad
Published: May 2018

This study employed classroom action research to investigate the impact of peer feedback strategy towards the improvement of eighth graders’ ability in writing narrative text. Planning, implementing, observing, and reflecting were conducted in one cycle that consisted of 7 meetings in which, 6 meeting for implementing the stages of peer feedback strategy, and 1 meeting for conducting the writing test. The result showed that students’ average score improved 13.86 points from the preliminary study result and got 91.2% positive responds from the students after this strategy had been implemented.
Factors Affecting the English Reading Literacy of Junior High School Students
Authors: Setianingsih Ika Sulis
Published: May 2018

This study aims at finding out how: (1) amount of input, (2)  amount of vocabulary, (3) learner’s motivation, (4) amount of input, amount of vocabulary, and learner’s motivation affect the English reading literacy; (5) amount of input affects amount of vocabulary, (6) amount of vocabulary affects learner’s motivation, and (7)  amount of input affects learner’s motivation. This study was an ex-post facto. The population comprised year VII students of SMP’s in Bantul District in the second semester of the academic year of 2013/2014. A sample of 384 students was established using the proportional sampling technique. The data were collected through a close-ended questionnaire and test. The close-ended questionnaire was used to collect the data related to students’ learning input and motivation. The test was used to find out the students’ knowledge on vocabulary and reading comprehension. The data were analyzed by employing the linear regression analysis for the linear variables, continued by the multiple regression analysis for the whole variables, and then followed by partial correlation. The findings showed that there is a significant effect of: (1) amount of input; (2) amount of vocabulary; (3) amount of inputs, the learner’s motivation, and amount of vocabulary; (4) amount of inputs and learner’s motivation; (5) learner’s motivation and amount of vocabulary; and (6) amount of inputs and amount of vocabulary on the English reading literacy of SMP students in Bantul District. Meanwhile, there is no significant effect of learner’s motivation on the English reading literacy of SMP students in Bantul District.
Student Language Anxiety in Learning English (A survey to non-English Major students in rural area)
Authors: Hidayati Tuti
Published: May 2018

Learners’ difficulties in learning a foreign language cannot merely be linked to the lack of ability or intelligence. Language anxiety or the feeling of tension, apprehension, fearfulness, and worry in language class had been pointed to greatly influence learner’s progress in mastering the target language. Highly anxious learners were found to achieve less and had low motivation. This study reports a survey investigating the level of language anxiety and its perceived causes and discusses some alternatives to deal with it. The participants were 114 non-English major students in State Islamic College of Teungku Dirundeng Meulaboh in West Aceh. Data were collected employing Foreign Language Classroom Anxiety Scale developed by Horwitz, Horwitz, and Cope, (1986). The finding indicated that the students participating in the study exhibited a moderate level of language anxiety obtaining FLCAS mean score 102.17. The main cause of language anxiety was attributed to fear of negative evaluation with the highest average mean 3,5. Communication apprehension and test anxiety were in the second and third rank with the average mean 3,3 and 3,1 respectively. Meanwhile, English classroom items were perceived to contribute the least to the students’ tense experience given the average mean 2,7. It is suggested that making the learners realize that they are not alone experiencing anxiety in learning a foreign language is crucial. Furthermore, it is important that teachers embrace a supportive and non-threatening role to provide a more effective foreign language learning.
English Teachers’ Perception on the Use of Authentic Assessment in 2013 Curriculum
Authors: Mardjuki Moch. Said
Published: May 2018

Authentic assessment in 2013 Curriculum leads the students to be autonomous learner and become higher order thinking. However, the English teachers prefer to use non-authentic than authentic assessment. This study seeks to find out how English teachers use the authentic assessment in the classroom and the barriers and the way the English teachers solve the problems in conducting authentic assessment. Interview was used to find out of five postgraduate English education students at a university in Bandung used authentic assessment in the classroom. Authentic assessment can encourage the English teachers and students to be more creative and optimize student’s participation in learning process. However, several challenges lead to the implementation of authentic assessment: purpose of assessment, fairness, time allotment, objectivity and reliability of scoring. Therefore, 2013 Curriculum should be clearly stated the types of authentic assessment, the indicators, and time allocation to its teaching material.
Organizações Regionais para o Ordenamento Pesqueiro: O poder ouve a ciência?
Authors: Gonçalves Leandra Regina
Published: May 2018

Um dos desafios à governança global é garantir a eficácia dos regimes internacionais que buscam reduzir ou solucionar problemas. O manejo dos estoques de peixes, como os atuns, é um bom exemplo da magnitude desse desafio. Nesse sentido, foram criadas as organizações regionais para o ordenamento pesqueiro, para resolver a crise internacional de pesca. O papel das comunidades epistêmicas e a forma como se dá sua influência nas decisões políticas são dois dos fatores considerados cruciais para a eficácia dos regimes internacionais. Então, através de uma avaliação do desenho institucional dos painéis científicos da Convenção sobre a Conservação dos Recursos Vivos Marinhos Antárticos, Convenção Internacional para a Conservação dos Atuns e a Convenção para a Conservação do Atum do Sul, essa pesquisa buscou responder se o poder ouviu a ciência e se isso trouxe mais eficácia para o manejo pesqueiro. Concluiu-se que os tomadores de decisão podemouvir a ciência e isso pode resultar em maior eficácia para o acordo, porém, é necessário que o desenho dos painéis científicos possa propiciar que conhecimentos e reivindicações científicas sejam desenvolvidos de forma isolada da política. Na prática, isso ainda não seconcretizou plenamente.
El Foro China-CELAC y el nuevo regionalismo para un mundo multipolar: desafíos para la Cooperación ´Sur-Sur´
Authors: Vadell Javier Alberto
Published: May 2018

La I Conferencia Ministerial del Foro China-CELAC que se llevó a cabo los días 8 y 9 de enero de 2015 en Beijing y el Policy Paper de la República Popular de China (RPC) para América Latina y el Caribe (ALC) de 2016 se tornaron los marcos institucionales del sistema de asistencia, cooperación, comercio e inversiones entre la RPC y los países de ALC. Las preguntas que orientan nuestro artículo son: ¿la experiencia de acercamiento de la CELAC con la RPC conseguirá institucionalizar un marco adecuado para la Cooperación Sur-Sur extra regional? ¿Permitirá ampliar márgenes de autonomía de los países de la región en las negociaciones o, por el contrario, legitimará una tendencia existente en la economía global, es decir, recrear patrones y redes de comercio e inversiones globales en los moldes pensados por los grandes polos del centro capitalista global? Para responder las preguntas el trabajo discute la cuestión regional en ALC para examinar históricamente el nacimiento de la CELAC con el objetivo de analizar las relaciones de China con la región de ALC y las perspectivas futuras.
The role of sodium carbonate in PAM coagulation-flocculation for oil acidized wastewater treatment
Authors: Qin Jinyi , Wang Hainan , Qin Chuan , Meng Hailong , Qu Wengang , Qian Hui
Published: May 2018

The pH value of oil acidized wastewater is relatively low (pH = 6.1), which seriously affects the flocculation of polyacrylamide (PAM). NaOH was used to adjust the pH value, but the maximum was only 7.5. The regulation was limited as the Ca2+ in aqueous phase up to 1,350 mg L−1 consumed OH−. A novel formulation of Na2CO3 + PAM was proposed to form CaCO3 floc core to facilitate PAM coagulation. When the concentration was above 400 mg L−1, the PAM precipitation tended to be maximum, followed by NaOH adjustment of pH to 8.0 that could enhance PAM flocculation successively. The sewage sludge (SS) remained and residue oil reduced to 25 mg L−1 and 34mg L−1 respectively. The analysis of the species and composition of fatty acids indicated that the coagulation-flocculation selectively effected the sedimentation of saturated fatty acids (SAT). This provides a new idea for recovery of high value-added residual oil. The optimal additive of Na2CO3 is expected as promising coagulant aid to improve the PAM coagulation-flocculation of oil acidized wastewater.
Nanocrystals: The Preparation, Precise Control and Application Toward the Pharmaceutics and Food Industry
Authors: Wu Cao , Chen Zhou , Hu Ya , Rao Zhiyuan , Wu Wangping , Yang Zhaogang
Published: May 2018

Crystallization is a significant process employed to produce a wide variety of materials in pharmaceutical
and food area. The control of crystal dimension, crystallinity, and shape is very important because they will
affect the subsequent filtration, drying and grinding performance as well as the physical and chemical properties
of the material. This review summarizes the special features of crystallization technology and the preparation
methods of nanocrystals, and discusses analytical technology which is used to control crystal quality and performance.
The crystallization technology applications in pharmaceutics and foods are also outlined. These illustrated
examples further help us to gain a better understanding of the crystallization technology for pharmaceutics
and foods.
Role of Oxidative Stress in Diabetic Retinopathy and the Beneficial Effects of Flavonoids
Authors: Ola Mohammad Shamsul , Al-Dosari Dalia , Alhomida Abdullah S.
Published: May 2018

Diabetic Retinopathy (DR) is one of the leading causes of decreased vision and blindness in developed
countries. Diabetes-induced metabolic disorder is believed to increase oxidative stress in the retina. This results in
deleterious change through dysregulation of cellular physiology that damages both neuronal and vascular cells. In
this review, we first highlight the evidence of potential metabolic sources and pathways which increase oxidative
stress that contribute to retinal pathology in diabetes. As oxidative stress is a central factor in the pathophysiology
of DR, antioxidants therapy would be beneficial towards preventing the retinal damage. A number of experimental
studies by our group and others showed that dietary flavonoids cause reduction in increased oxidative stress
and other beneficial effects in diabetic retina. We then discuss the beneficial effects of the six major flavonoid
families, such as flavanones, flavanols, flavonols, isoflavones, flavones and anthocyanins, which have been studied
to improve retinal damage. Flavanoids, being known antioxidants, may ameliorate the retinal degenerative
factors including apoptosis, inflammation and neurodegeneration in diabetes. Therefore, intake of potential dietary
flavonoids would limit oxidative stress and thereby prevent the retinal damage, and subsequently the development
of DR.
Engineering of Microbial Cell Factories for the Production of Plant Polyphenols with Health-Beneficial Properties
Authors: Dudnik Alexey , Gaspar Paula , Neves Ana Rute , Forster Jochen
Published: May 2018

Polyphenols form a group of important natural bioactive compounds with numerous ascribed healthbeneficial
attributes (e.g. antioxidant, anti-inflammatory, anti-microbial and tumor-suppressing properties). Some
polyphenols can also be used as natural dyes or plastic precursors. Notwithstanding their relevance, production of
most of these compounds still relies on extraction from plant material, which for most of it is a costly and an
inefficient procedure. The use of microbial cell factories for this purpose is an emerging alternative that could
allow a more efficient and sustainable production. The most recent advances in molecular biology and genetic
engineering, combined with the ever-growing understanding of microbial physiology have led to multiple success
stories. Production of multiple polyphenolic compounds or their direct precursors has been achieved not only in
the common production hosts, such as Escherichia coli and Saccharomyces cerevisiae, but also in Corynebacterium
glutamicum and Lactococcus lactis. However, boosting production of native compounds or introduction of
heterologous biosynthetic pathways also brings certain challenges, such as the need to express, balance and maintain
efficient precursor supply. This review will discuss the most recent advances in the field of metabolic engineering
of microorganisms for polyphenol biosynthesis and its future perspectives, as well as outlines their potential
health benefits and current production methods.
Role of Formyl Peptide Receptors in Gastrointestinal Healing
Authors: Prevete N. , de Paulis A. , Sgambato D. , Melillo R.M. , D`Argenio G. , Romano L. , Zagari R.M. , Romano M.
Published: May 2018

The wound healing and the barrier restoration of the gastrointestinal (GI) mucosa must be continuously
ensured to allow homeostasis of the gastrointestinal tract and of all the surrounding tissues. Several lines of the
evidence report a key role of innate immunity, and in particular of Pattern Recognition Receptors (PRRs), in
controlling the homeostasis of GI tract by sensing commensal and pathogen bacteria, activating the immune response
and regulating epithelial repair, thus guaranteeing the morphological and functional recovery of the injured
tissue. We will discuss the role of a particular class of PRRs - the Formyl Peptide Receptors - in the homeostasis
of GI mucosa. We here report the results of studies that strongly suggest the possibility that the activation of
FPRs is crucial in the maintenance of homeostasis of the GI tract and provide indications of the potential clinical
relevance of new treatment regimens involving FPR modulation for several GI disorders.
Polyphenols, their Metabolites and Derivatives as Drug Leads
Authors: Almeida A. Filipa , dos Santos Claudia Nunes , Ventura Maria Rita
Published: May 2018

In this non-comprehensive review, the potential of natural polyphenols as lead compounds for the
design and synthesis of new molecules with potential application in several diseases was highlighted. Organic
synthesis has been essential for the development of new analogues of naturally found polyphenols, providing a
wide range of structural modifications for structure-activity relationship studies and improving or modulating the
biological activity of the promising compounds.
Switching Dipeptidyl Peptidase-4 Inhibitors to Tofogliflozin, a Selective Inhibitor of Sodium-Glucose Cotransporter 2 Improve Arterial Stiffness Evaluated by Cardio-Ankle Vascular Index in Patients with Type 2 Diabetes: A Pilot Study
Authors: Bekki Munehisa , Tahara Nobuhiro , Tahara Atsuko , Igata Sachiyo , Honda Akihiro , Sugiyama Yoichi , Nakamura Tomohisa , Sun Jiahui , Kumashiro Yuki , Matsui Takanori , Fukumoto Yoshihiro , Yamagishi Sho-ichi
Published: May 2018

Background:

We have found that anagliptin, a dipeptidyl peptidase-4 inhibitor (DPP-4) significantly
ameliorates arterial stiffness in Type 2 Diabetes Mellitus (T2DM) patients compared with an
equivalent hypoglycaemic agent, glimepiride. However, it remains unclear whether switching DPP-4
inhibitors to tofogliflozin, a selective inhibitor of Sodium-Glucose Cotransporter 2 (SGLT2) improves
arterial stiffness in T2DM patients.

Methods:

Nineteen T2DM patients who had received DPP-4 inhibitors for at least 1 year were enrolled
in this study. Clinical parameters and arterial stiffness evaluated by cardio-ankle vascular index (CAVI)
were measured at baseline and after 6-months treatment with tofogliflozin.

Results:

At 6 months after switching to tofogliflozin, CAVI, waist circumference, body weight, body
mass index, subcutaneous and visceral fat volume, white blood cell number, fasting plasma insulin, uric
acid, aspartate transaminase (AST), γ-glutamyl transferase (GTP), and advanced glycation end products
(AGEs) were significantly reduced, while red blood cell number, haemoglobin, and HbA1c values were
increased. When stratified by median values of change in CAVI after switching to tofogliflozin
(ΔCAVI), baseline serum levels of AGEs were significantly higher in the low ΔCAVI group (high responder)
than in the high one (low responder). ΔAST and ΔGTP were positively correlated with
ΔCAVI.

Conclusion:

The present study suggests that switching DPP-4 inhibitors to tofogliflozin ameliorates
arterial stiffness in T2DM patients partly via improvement of liver function. Baseline serum levels of
AGEs may identify patients who improve arterial stiffness more after treatment with tofogliflozin.
Characteristics and Outcomes of Patients with Anti-Glomerular Basement Membrane Antibody Disease and Anti-Neutrophil Cytoplasmic Antibodies
Authors: Balderia Percy G. , Andeen Nicole , Jefferson Jonathan A.
Published: May 2018

Background:

It is unclear whether patients with Anti-Glomerular Basement Membrane
(GBM) disease and Anti-Neutrophil Cytoplasmic Antibodies (ANCA), so called “Double-Positive”
(DP), have a different clinical presentation and outcome compared to patients with anti-GBM antibody
disease alone. This study describes the clinical and histologic characteristics as well as the patient
and renal outcomes of DP patients at the University of Washington compared to patients with
anti-GBM antibody disease alone.

Methods:

Adults admitted to the University of Washington and Harborview Medical Centers from
2000 to 2016 who had a kidney biopsy showing anti-GBM disease characterized by crescentic
glomerulonephritis with strong linear staining of glomerular basement membranes for IgG by immunofluorescence
were included. Subjects were classified into anti-GBM or DP based on serologic
testing. Information on demographics, clinical presentation, biopsy findings, initial treatment, and
rates of relapse and patient and renal survival were collected. Continuous and categorical variables
were analyzed using the Mann-Whitney U and Fisher’s exact tests, respectively.

Results:

There were 6 anti-GBM and 7 DP patients. Two patients were lost to follow-up after one
year. There was no significant difference in clinical presentation or outcomes between the two
groups. Two DP patients had greater than 50% global glomerulosclerosis. All the subjects developed
ESRD. Two DP patients had a relapse while off immunosuppression. Two patients in each
group died within 5 years of diagnosis.

Conclusion:

Two DP patients in our cohort had a relapse within 5 years of diagnosis. Multicenter
studies are needed to determine whether DP patients have a higher relapse rate and need prolonged
immunosuppression.
Pain-Related Behavior and Brain Activation in a Cynomolgus Macaque Model of Postoperative Pain
Authors: Hama Aldric , Natsume Takahiro , Ogawa Shin`ya , Awaga Yuji , Hayashi Ikuo , Matsuda Akihisa , Takamatsu Hiroyuki
Published: May 2018

Background:

Inadequate postoperative pain management could lead to persistent pain and
this is, in part, due to incomplete understanding of the mechanism of postoperative pain. Currently
available rodent models may have limited translatability to clinical postoperative pain. Thus, a preclinical
model of postoperative pain was developed in the cynomolgus macaque, a species that is
phylogenetically closer to humans than rodents.

Method:

The presence of pressure hypersensitivity was assessed with non-noxious pressure applied
proximally and distally (approximately 10 cm) to an abdominal incision in macaques. The effect of the
opioid morphine (intramuscular, i.m.), the nonsteroidal anti-inflammatory drug diclofenac (i.m.) and
the anticonvulsant pregabalin (i.m.) on pressure hypersensitivity was evaluated one and two days following
surgery. Brain activation during non-noxious pressure stimulation was observed with functional
magnetic resonance imaging.

Results:

Hypersensitivity to non-noxious pressure applied proximally and distally (approximately 10
cm) to the incision was observed, lasting for up to seven days and three days, respectively, following
surgery. Postoperative pressure hypersensitivity was attenuated with morphine but not with either diclofenac
or pregabalin. Bilateral activation of the insular cortex and cingulate cortex was observed
during non-noxious pressure stimulation proximal to the incision, which was attenuated with morphine.
By contrast, pregabalin reduced only cingulate cortex activation.

Conclusion:

The lack of antinociceptive efficacy of pregabalin on postoperative pain could be due to
the incomplete suppression of pressure-evoked brain activation. It is speculated that incomplete postoperative
pain relief observed in general could be due to residual or persistent activity of key pain nuclei
such as the insular cortex. The current macaque model could be used for further elaborating the
mechanism of postoperative pain as well as confirming the efficacy of potential treatments for the
management of postoperative pain.
Installation and Maintenance Principles of Seismic Isolators: Erzurum Health Campus
Authors: Sağıroğlu Merve , Maali Mahyar , Aydın Abdulkadir Cüneyt
Published: May 2018

Background:

The objective of isolation is to reduce the seismic forces transmitted through the structure using active and/or passive insulation systems.Seismic isolators, which are passive insulation systems and are placed between the foundation of the structure and the structure, are discussed throughout this study. Isolators consist of rubber layers that have horizontal flexibility, steel layers that increase rigidity and a lead or ball core, which increases vertical stiffness. Installation and maintenance of seismic isolators require great care in order not to exceed the displacements/section forces envisaged at the design of the structure during the earthquake.

Objective:

Installation and maintenance principles of the friction pendulum type isolators used in Erzurum Health Campus (hospital) are presented throughout this study. While the seismic isolators are anchoraged to directly concrete in the general application, they are placed between two steel plates of type S355J2 in this application, because of cold-weather conditions. To evaluate this condition, it is investigated the models with and without steel plate and compared to each other.

Methodology:

The models with and without steel plate were formed using finite-element method to compare the stress distributions on the isolator.

Conclusion:

The results demonstrated that the model with steel plates occur the uniform stress through surface and keep under control deformation of cross-section in the reinforced concrete.
Clinical Model to the Analysis of Synergy Pattern Changes of Back Muscles and its Relationship with the Occurrence of Fatigue
Authors: Torbati Armin HakKak Moghaddam , Tahami Ehsan , Kobravi Hamid Reza
Published: May 2018

Background:

Right sitting not only leads to flatness of the lumbar spine and waistline, it also causes other problems for health. The curved body pushes into lungs and breathing will be problematic.

Purpose:

The main purpose of this study was investigating changing procedure of lumber muscles patterns and its relationship with the occurrence of fatigue.

Methods:

Participants were ten male with average age 24 ± 1. Firstly, the process of fatigue during sitting was observed by mid-frequency index. For performing the necessary analysis, the 10-second window of time was used. The 15 minutes of time trial was divided into 3 sub-terms. Each sub-term was investigated separately. The sub-terms contain: The beginning of record until the 90th second, from the 90th second to the 600th second and from the 600th second to the 900th second.

Results:

Results showed that in each subject there were synergy patterns in both of the first and the second sub-terms. Maximum error between basis vectors in all of the subjects were 0.87 and 0.79 respectively and standard deviations were 5 and 10 respectively (Mean square error index). In some participants, there were not any synergy patterns in the third sub-term (minimum error between basis vectors in all of the subjects was 18 and standard deviation was 7.5) while in other participants, their muscles still followed special synergy patterns (maximum error between basis vectors in all of the subjects was 0.98 standard deviation was 7.5).

Conclusions:

Comparing the synergy patterns between different participants has determined that the synergy patterns were the same only in the first sub-term.
Optimism in a sea of uncertainties: the journalistic coverage on the research of new medicines in Brazil
Authors: Fioravanti Carlos Henrique , Fioravanti César Maschio
Published: May 2018

This paper deals with the journalistic coverage of biologically active compounds presented as promising drugs in Brazil. The sample consists of 214 journalistic stories on 40 compounds published in two daily newspapers and a monthly science magazine from January 1990 to December 2016. After 27 years, although journalists and scientists had claimed that all compounds would become drugs in a few years, only two completed the evaluation tests and were approved for commercialisation. The paper provides a series of strategies to build a more analytical view on drug research and development.
Evaluación del control interno en el proceso de tesorería de las pequeñas y medianas empresas de Medellín
Authors: Grajales-Gaviria Daniel Alberto , Castellanos-Polo Orlando Carmelo
Published: May 2018

Al evaluar la empresa por áreas de trabajo, se identifica que el departamento más susceptible a fraudes es el de Tesorería, por esta razón, se propone evaluar la estructura del control interno con énfasis al ciclo transaccional del proceso de tesorería en las pequeñas y medianas empresas por medio de una muestra representativa en el municipio de Medellín.

Esta revisión permitirá identificar debilidades en los procesos y brindar opciones de mejora con el fin de garantizar la eficacia, eficiencia, efectividad y economía en la gestión institucional.

El alcance de esta investigación está basado en los componentes del modelo de control interno COSO, los cuáles serán el enfoque modular para la revisión del proceso de tesorería; Se revisarán: El proceso de cuentas por pagar, el proceso de cuentas por cobrar, el proceso de recaudo de efectivo y el proceso de pagos de obligaciones.

El resultado de esta investigación permitirá alcanzar el objetivo de identificar las principales falencias en el proceso de tesorería en cuanto a los mecanismos de control interno que las pequeñas y medianas empresas de Medellín tienen estipulados.
El aprendizaje organizacional (AO) y el desempeño empresarial bajo el enfoque de las capacidades dinámicas de aprendizaje
Authors: Londoño-Patiño Julio Albeiro , Acevedo-Álvarez Carlos Alberto
Published: May 2018

El objetivo de este trabajo es presentar una reflexión sobre la relación entre el aprendizaje organizacional y el desempeño organizacional, bajo el enfoque de las capacidades dinámicas de aprendizaje, considerando las diversas tipologías que han sido planteadas por diferentes estudios para clasificar el aprendizaje organizacional que ocurre en las organizaciones, según su alcance colectivo o su nivel individual. Con base en estas tipologías, se consideran los factores que condicionan el desarrollo del aprendizaje con el desempeño empresarial, permitiendo encontrar las razones por las cuales las organizaciones deben asumir el aprendizaje como una plataforma de competitividad y permanencia en el tiempo como medida de mantenibilidad en entornos dinámicos y siempre cambiantes.

En términos metodológicos, para relacionar el AO, las capacidades dinámicas de aprendizaje y el desempeño, se realizó una revisión de la literatura de orden descriptiva por periodo de tiempo, usando como referencia conceptos relacionados a la organización que aprende, partiendo desde el tipo de aprendizaje organizacional y el entorno que lo rodea (individual y colectivo); por último, se realizan unas consideraciones del aprendizaje organizacional y el desempeño empresarial que destaca la importancia del AO bajo el enfoque de las capacidades dinámicas y su incidencia en el desempeño, donde se evidencia su importancia en la competitividad empresarial desde sus diferentes niveles y estructuras.
Preferencias Estrategias de desarrollo económico local para el municipio de Girardota
Authors: Rojas-Arenas Iván Dario , Cardona-Quintero John Alejandro , Gallego-Alzate José Benjamín
Published: May 2018

El desarrollo económico endógeno supone un cambio de paradigma en la forma de pensar el desarrollo en las regiones, en un intento por explicar los procesos de acumulación y generación de riqueza, y el papel que juegan los actores locales en estos procesos. En el presente artículo, proponemos unas estrategias de desarrollo económico local para el Municipio de Girardota (del Departamento de Antioquia- Colombia), obtenidas a partir de una investigación participativa que incluyó un diagnóstico, con el fin de identificar las vocaciones económicas, y así definir objetivos y estrategias que puedan ser ejecutadas a partir de programas y proyectos. Las estrategias formuladas apuntaron a la solución de cuatro problemas fundamentales de la localidad: desempleo, baja calidad y poca pertinencia del sistema educativo, competitividad menguada en sectores claves de la economía local y escasos niveles de participación ciudadana. Las conclusiones a las que llegamos muestran la importancia de la participación real de la comunidad en la elaboración de estrategias de desarrollo alineadas con los intereses y necesidades de los distintos actores locales.
Análise das condições de trabalho na educação especial nos planos municipais de educação do interior da Bahia
Authors: Silva Osni Oliveira Noberto da , Miranda Theresinha Guimarães , Bordas Miguel Angel Garcia
Published: May 2018

Este artigo tem como objetivo investigar como as condições de trabalho dos professores da Educação Especial, são tratados nos planos municipais de educação das cidades da região do Piemonte da Diamantina. O estudo foi desenvolvimento a partir da pesquisa documental e análise dos dados foi feita através da Hermenêutica objetiva. A articulação entre o Plano Nacional e os Planos Municipais é visível. Ainda que não exista a garantia de que tudo que foi colocado como meta seja de fato materializado, os Planos servem inegavelmente como importantes instrumentos de diagnósticos e planejamento de ações para a melhoria da Educação de curto a médio prazo.
Application of threshold vector error correction model (TVECM) in describing adjustment of interest rate of working capital credit to BI rate movement
Authors: Sohibien Gama Putra Danu
Published: May 2018

Knowledge about bank behavior in adjusting the interest rate to BI rate movement is important not only for debtors to make a decision to borrow money, but also for government to know whether BI rate as a monetary policy tool success in influencing the movement of interest rate. The approach used for analyzing the data in this paper is TVECM. The data used in this paper are interest rate of working capital credit of conventional bank and BI rate of January 2008–July 2016. Bank is more agressive in correcting the disequilibrium by increasing the interest rate of working capital credit than decreasing it. Interest rate of working capital credit is significantly adjusted by bank approximately 64.95% of its disequilibrium when the disequilibrium is lower than 0.96. When it is between 0.96 and 0.76, interest rate of working capital credit will be adjusted approximately 11.87% of its disequilibrium.When it is higher than 0.76, interest rate of working capital credit will be adjusted approximately 11.88% of its disequilibrium. Moderate interest rate of working capital credit based on BI rate consideration is between 1.74 BI rate –0.96 and 1.74 BI rate +0.76. According to the selection criteria values, TVECM is better than VECM and VAR in modeling relationship between BI rate and interest rate of working capital.
A simple parameterization for tsunami run-up prediction
Authors: Cholifah Latifatul , Prastowo Tjipto
Published: May 2018

The linear shallow-water approximation is commonly used to describe tsunami propagation, where the wave is assumed as a long surface gravity wave. The evolution of wave height during its propagation from offshore to onshore is a classic problem. When arriving at a shoreline, the increased wave height causes severe destruction on infrastructures and fatalities. This problem has then been an important issue within the context of disaster risk reduction as it gives rise to the importance of tsunami run-up prediction. Using maximum run-up data from past events, we tested the applicability of the Green’s law based on shoaling only to calculate run-ups and found that the basic Green’s law was in doubt. Then, we examined energy density conservation involving refraction effect but no dissipation and derived a simple formula for parameterizing run-up height. Detailed descriptions on factors affecting run-ups, such as complex bathymetry and topography are not yet considered in the current study. The aim of this study is therefore to determine whether the modified Green’s law is applicable for tsunami run-up prediction using local water depths as external parameters and ray spacing widths in the normal direction of wave fronts related to refraction. The results are consistent with the measured run-ups, where approximately 70% of total points of observations confirm the modified Green’s law with a reasonable accuracy.
Analysis of rotating object using video tracker
Authors: Suwarno Djoko Untoro
Published: May 2018

The purpose of this paper is to show the use of video tracker to analyze circular motion. Measurement of circular motion such as angular velocity and angular acceleration is not easy to do observation and measurement directly. Through the video tracker tool, the analysis of speed and rotation acceleration becomes easier. The rotating object used as a research object is a spinner fidget. The initial velocity of the rotation depends on the pull of the finger on the spinner. The duration of rotating spinner fidget depends on the inertia and attenuation that occurs. Camera position and resolution of the camera greatly determine the data on the video tracker. The standard camera capability of 30 frames per second is less capable of capturing objects that rotate with high resolution.
Dört boyutlu mesleki bağlılık ölçeği uyarlama çalışması
Authors: UTKAN Çağrı , KIRDÖK Oğuzhan
Published: May 2018

Bu araştırmada Blau (2003) tarafından geliştirilen dört boyutlu
Mesleki Bağlılık Ölçeğini Türkçeye uyarlayarak, geçerlik ve güvenirliğini
incelemek amaçlanmaktadır. Araştırmanın çalışma grubunu Adana ili Çukurova
ilçesindeki devlet okullarında görev yapan toplam 525 öğretmen oluşturmaktadır.
Doğrulayıcı ve açımlayıcı faktör analizi için iki farklı öğretmen grubundan
veri toplanmış, toplanan veriler SPSS 24.0 ve AMOS 22.00 istatistik programları
ile analiz edilmiştir. Yapı geçerliği kapsamında yapılan analiz sonuçları 22
maddeden ve dört boyuttan oluşan modelin iyi uyum değerlerine sahip olduğunu
göstermiştir (x2=421.635, sd=200, x2/sd=2.108, NFI=.90,
IFI=.95, CFI=.95, GFI=.87, RMR=.80, RMSEA=.64, SRMR=.06). Faktör analizi
sonuçlarına göre dört boyuttan oluşan ölçek, varyansın %68.88’ini
açıklamaktadır. Ölçeğe ait Cronbach Alfa iç tutarlık katsayısı .90 olarak
bulunmuş, alt ölçeklere ait iç tutarlık katsayıları ise .83 ile .95
arasındadır. Elde edilen bulgular, araştırma kapsamında uyarlaması yapılan
Mesleki Bağlılık Ölçeğinin mesleki bağlılığın ölçülmesinde geçerli ve güvenilir
bir ölçme aracı olduğunu göstermiştir.
Öğrenmede motivasyonu etkileyen faktörlerin belirlenmesi: Isparta Meslek Yüksekokulu öğrencileri üzerine bir uygulama
Authors: HATIRLI Yüksel , DURAN Yasemin
Published: May 2018

Motivasyon, öğrenmede ve başarılı
olmada etkili olan en önemli faktörlerdendir. Eğitimde motivasyon birçok farklı
yaklaşımlar uygulanarak artırılabilir. Bu yaklaşımların, öğrencilerin öğrenmesi
üzerinde önemli bir etkisi vardır. Öğrenciler tutarlı bir şekilde motive
olmadıkları durumda öğrenmede problemler ortaya çıkmaktadır. Bu çalışmanın
temel amacı, Süleyman Demirel Üniversitesi Isparta Meslek Yüksekokulu’nda
öğrenim gören Tasarım, Halkla İlişkiler Tanıtım ve Pazarlama programları
birinci ve ikinci sınıf öğrencilerinin öğrenmede etkili olabilecek temel
motivasyon unsurlarını incelemek, öğrencilerin öğrenmede motivasyonlarını
etkileyen faktörlerin geliştirilen hipotezlerle test edilmesidir. Ayrıca
eğitimcilere öğrencileri motive etmek için kullanılabilecek yöntemlerden
öneriler sunmaktır. Bu çalışmada başlıca motivasyon teorilerinin öğrenmeye
etkisi araştırılmış olup, ardından Isparta Meslek Yüksekokulu’nda öğrenim gören
264 öğrenci ile anket uygulamasının sonuçları ortaya konmuştur. Anketler sonucu
elde edilen ham veriler, istatistik paket programı olan SPSS (20.0) yardımıyla,
frekans dağılımları ve çapraz tabloları oluşturularak değerlendirilmiş ve motivasyonlarını
etkileyen faktörler ortaya konan hipotezlerle Mann-Whitney U testi ve Kruskal
Wallis testi ile analiz edilmiştir. Çalışma sonucunda elde edilen bulgular ışığında
öğrencilerin öğrenme süreçlerini motivasyon temelli olarak geliştirecek
öneriler sunulmuştur.
Otel işletmelerinin müşteri ilişkileri yönetimine bakışı: Isparta örneği
Authors: DİKİCİ F. Hülya
Published: May 2018

Bu çalışmanın amacı, otel yöneticilerinin
müşteri ilişkileri yönetimine bakış açıları, otel işletmelerinde müşteri ilişkileri
yönetimi kapsamında gerçekleştirilen çalışmalar ve mevcut durumun ortaya konulmasıdır.
Bu amaçla, Isparta şehir merkezinde bulunan 3 yıldız ve üzerindeki otel yöneticileri
hedef kitle olarak belirlenmiştir. Hedef kitle ile yarı yapılandırılmış görüşme
tekniği esas alınarak görüşülmüş ve betimsel ve sistematik analiz yöntemi ile Isparta’daki
otellerin müşteri ilişkileri yönetimi analiz edilmiştir. Görüşmelerin analizi sonucunda
otel yöneticileri, otel müşterilerinin memnuniyetini sağlayarak müşteri sadakatinin
yaratılacağını belirtmişlerdir. Yöneticiler, aynı zamanda müşteri memnuniyeti ve
sadakatin, beraberinde otel işletmelerinin en temel amaçlarından olan kârlılık ve
büyüme hedeflerine ulaşılabilirliği kolaylaştırdığını vurgulamışlardır.
Implementation of Thematic Instructional Model in Elementary School
Authors: Chumdari Chumdari , Sri Anitah Sri Anitah , Budiyono Budiyono , Nunuk Suryani Nunuk
Published: May 2018

The purpose of this research is to know the implementation of thematic instructional model and the achievement of student learning outcomes in the field of knowledge, skills, and attitude/character. This quantitative research was conducted in Elementary School in Surakarta City, from November 2015 to February 2016. The teachers and 63,433 students from 253 elementary schools became the population of this study. Samples were obtained through multistage cluster random sampling technique. The samples were eight classes from six schools in Laweyan Sub-district. Data collection involved observation, interview, questionnaire, and documentation technique. Data analysis used comparative analysis technique. The result of the research showed that in general, the thematic learning works appropriately. It can be elaborated as follows: (1)The planning and implementation of thematic learning is classified appropriate, (2) Student learning activity is less optimal mainly due to direct learning methods, (3) Average score of learning implementation is 76.5 on a scale from 0-100, (4) Average score of learning outcomes in terms of knowledge and skills is 83.5 on a scale from 0-100, (5) Average score of attitude aspect (behavior, craft, and neatness) is classified as ‘Good’, (5) Average score of student characters is 2.77 on a scale from 0-4. The score is categorized ‘Good’ or ‘in progress’, in which the students have shown particular but inconsistent behaviors. This character should be improved. In overall, the thematic model in Elementary School has been successfully implemented.
Inequalities of Hermite–Hadamard Type for GA-Convex Functions
Authors: Dragomir Sever S.
Published: May 2018

Some inequalities of Hermite-Hadamard type for GA-convex functions defined on positive intervals are given.
Effect of number of parents on some important biometric genetic parameters in rapeseed (Brassica napus L.)
Authors: Rameeh Valiollah
Published: May 2018

Half F2 diallel crosses of eight spring cultivars of rapeseed were used in partial circulant diallel analyses to estimate biometric genetic parameters for phenological traits, yield components and seed yield. The greatest variation in the GCA-to-SCA mean square ratio was related to days to flowering, and its lowest variation to days to maturity. A high coefficient of variation of the narrow-sense heritability estimate was obtained for days to maturity, followed by plant height and seed yield. For diallel analysis with a low number of parents, the differences of the heritability estimates of the traits were small; therefore, for precise estimation of heritability, a high number of diallel crosses will be preferred.
Factors Influencing the Selection of Retail Chains with Large Purchasing in Bosnia and Herzegovina
Authors: Gluhović Nikola
Published: May 2018

The aim of the paper is to analyse the impact of factors that dominantly influence the choice of trade chains with large purchases in Bosnia and Herzegovina in retail trade, mainly food, beverages and household hygiene products. The survey was conducted using the survey questionnaire on a representative sample of 350 respondents in Sarajevo, Banja Luka and Mostar, with the aim of determining the prevailing buying behaviour of consumers during large purchases in Bosnia and Herzegovina, in retail outlets from large retail chains. For the purpose of analysing the collected data, the statistical package of SPSS was used, and in particular the methods: variance analysis (ANOVA) and multivariate variance analysis (MANOVA). On the basis of the obtained results, factors that have the greatest influence on the selection of retail chains in large purchases in Bosnia and Herzegovina at the level of Sarajevo, Banja Luka and Mostar can be determined. The contribution of this research is reflected in the recognition and understanding of the behaviour of consumers in the selection of retail chains in Bosnia and Herzegovina. The correct understanding of the factors that lead consumers in making large purchases is of essential importance for the business of retail chains in Bosnia and Herzegovina.
The Resourse Valorisation of Authentic Tourist Offer of Western Serbia
Authors: Gligorijević Aleksandar , Novović Milan
Published: May 2018

In recent decades, from a global scale aspect, tourism demand is becoming more differentiated. On one hand, a preserved natural environment and clean air are demanded, while, on the other hand, a growing number of tourists want to travel and see cultural and historical heritage of the area in which they are spending their holiday. In order to compete in the world tourist market, an area must possess various and extensive resources. Therefore, new destinations that, above all, have a rich original tourist offer are required. Since Western Serbia has significant natural and anthropogenic resources, this paper explores its original tourist potential. In this sense, with the use of modern methodologies for evaluating the still untapped potential tourist area, this paper presents an approach to valorisation, both natural and anthropogenic resources of Western Serbia. The research aims, through this evaluation, to show how, in what way these resources can be placed in the function of tourism exploitation and greater involvement of Western Serbia in contemporary touristic trends.
Recurrent Multi-Organ Cystic Echinococcosis
Authors: Habor Adriana , Sidlovszky Noémi Ecaterina , Török Edina , Simu Iunius , Copotoiu Monica , Mureșan Larisa
Published: May 2018

Cystic echinococcosis is the disease that occupies, together with trichinosis, the first place in the zoonoses in Romania. We present the case of a 75-year-old urban patient known for echinococcosis, firstly operated for bone cysts in the right coxofemoral joint at the age of 24, then in 2000 she was operated for a lung hydatid cyst and in 2011 she underwent a surgery for recurrent bone echinococcosis.

After a 7-year lull, she returns due to the appearance of tumorous masses in the abdominal right flank, the right thigh, accompanied by pain in the right coxofemoral joint, functional impotence of the right lower limb, asthenia, anorexia. Based on clinical, immunological, imagistic examinations, the diagnosis of cystic echinococcosis localised in the liver, bone and muscle was established. Since the patient in association had ischaemic heart disease in NYHA III (New York Heart Association) congestive heart failure, surgical treatment was delayed and preoperative treatment with Albendazole 10-15mg/kg/day was started. Initially we will apply a conservative treatment, laparoscopic drainage and aspiration of the contents, saline instillation and aspiration.