bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Beef Production System on the Health, Performance, Carcass Characteristics, and Meat Quality of Holstein Bulls
Authors: Rutherford Naomi H. , Gordon Alan W. , Arnott Gareth , Lively Francis O.
Published: October 2020

The aim of this study was to evaluate the effect of production system on the health, performance, carcass characteristics, and meat quality of autumn born (AB) and spring born (SB) Holstein bulls. The study involved a total of 224 Holstein bulls and was conducted over two years (2017/18, 2018/19). The four production system treatments differed during the grower period and consisted of: (i) grazed with no concentrate supplementation (G), (ii) grazed with 2 kg concentrate supplementation per day (G2), (iii) grazed with ad libitum access to concentrates (GA) and (iv) housed with ad libitum access to concentrates and grass silage (HA). All bulls were finished on ad libitum concentrates and grass silage and were slaughtered at a mean age of 15.5 months. Total grower dry matter intake (DMI) (p < 0.001) and total finishing DMI (p < 0.001) differed between production systems for both AB and SB bulls, with that of GA bulls being the greatest in both cases. Average daily gain (ADG) during the grower period was greatest (p < 0.001) for the HA production system in the AB bulls and the GA and HA production systems for the SB bulls. However, during the finishing period, G bulls had the greatest (p < 0.001) ADG of the AB bulls, while that of the SB bulls was from the G2 production system (p < 0.001). For both AB and SB, bulls on the GA and HA production systems produced heavier cold carcass weights than the G and G2 bulls (p < 0.001). There was no significant difference (p > 0.05) in health, carcass conformation, fat classification, or meat quality between production systems.
Antibacterial and Cytotoxic Activities of Ten Commercially Available Essential Oils
Authors: Oliveira Ribeiro Sofia , Fontaine Véronique , Mathieu Véronique , Zhiri Abdesselam , Baudoux Dominique , Stévigny Caroline , Souard Florence
Published: October 2020

There is a huge concern in the medical field concerning the emergence of bacterial resistance to antibiotics. Essential oils are a source of antibacterial compounds that can overcome this problem. Ten essential oils that are commercially available were investigated in the present study: ajowan, basil, German chamomile, Chinese cinnamon, coriander, clove, lemongrass, Spanish lavender, oregano and palmarosa. Their direct, synergistic and indirect antibacterial activities were evaluated against different human pathogenic Gram-positive and Gram-negative strains. To evaluate their possible use in clinics, the cytotoxicity of these essential oils was also tested on keratinocyte and epithelial cell lines. Except for the Chinese cinnamon, coriander and lemongrass, all other essential oils presented no cytotoxicity at 32 and 16 μg/mL. The highest indirect antibacterial activities were observed with the palmarosa and Spanish lavender in association with penicillin V. These two associations presented a 64-fold decrease against a resistant strain of Staphylococcus aureus, however, at a cytotoxic concentration. It can also be highlighted that when tested at a non-cytotoxic concentration, the activity of oregano in association with penicillin V presented an eight-fold decrease. These results show the interest to use essential oils in combination with antibiotics to reduce their concentrations inside drugs.
Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity
Authors: Barran Gervonne , Kolodziejek Jolanta , Coquet Laurent , Leprince Jérôme , Jouenne Thierry , Nowotny Norbert , Conlon J. Michael , Mechkarska Milena
Published: October 2020

Ocellatins are peptides produced in the skins of frogs belonging to the genus Leptodactylus that generally display weak antimicrobial activity against Gram-negative bacteria only. Peptidomic analysis of norepinephrine-stimulated skin secretions from Leptodactylus insularum Barbour 1906 and Leptodactylus nesiotus Heyer 1994, collected in the Icacos Peninsula, Trinidad, led to the purification and structural characterization of five ocellatin-related peptides from L. insularum (ocellatin-1I together with its (1–16) fragment, ocellatin-2I and its (1–16) fragment, and ocellatin-3I) and four ocellatins from L. nesiotus (ocellatin-1N, -2N, -3N, and -4N). While ocellatins-1I, -2I, and -1N showed a typically low antimicrobial potency against Gram-negative bacteria, ocellatin-3N (GIFDVLKNLAKGVITSLAS.NH2) was active against an antibiotic-resistant strain of Klebsiella pneumoniae and reference strains of Escherichia coli, K. pneumoniae, Pseudomonas aeruginosa, and Salmonella typhimurium (minimum inhibitory concentrations (MICs) in the range 31.25–62.5 μM), and was the only peptide active against Gram-positive Staphylococcus aureus (MIC = 31.25 μM) and Enterococcus faecium (MIC = 62.5 μM). The therapeutic potential of ocellatin-3N is limited by its moderate hemolytic activity (LC50 = 98 μM) against mouse erythrocytes. The peptide represents a template for the design of long-acting, non-toxic, and broad-spectrum antimicrobial agents for targeting multidrug-resistant pathogens.
Changes in Bioactive Compounds, Antioxidant Activity, and Nutritional Quality of Blood Orange Cultivars at Different Storage Temperatures
Authors: Habibi Fariborz , Ramezanian Asghar , Guillén Fabián , Castillo Salvador , Serrano María , Valero Daniel
Published: October 2020

Information about the postharvest physiological behavior of blood orange cultivars can provide comprehensive insight into the best period of storage to maintain the highest fruit quality during prolonged cold storage. In this paper, changes in nutritional quality, bioactive compounds, and antioxidant enzymes in the juice of four blood orange cultivars (“Moro”, “Tarocco”, “Sanguinello”, and “Sanguine”) stored at 2 and 5 °C were studied. Parameters were measured after 0, 30, 60, 90, 120, 150, and 180 days, plus 2 days at 20 °C for shelf life. Sucrose was the sugar found in higher concentrations and decreased during storage in all cultivars, as did glucose and fructose. Organic acids decreased at both temperatures, with the highest content found in “Sanguinello”, especially major (citric acid) and ascorbic acid. Total phenolics content (TPC), total anthocyanins (TAC), and individual cyanidin 3-glucoside and cyanidin 3-(6″-malonylglucoside) increased for all cultivars, with “Sanguinello” having higher concentrations. The antioxidant enzymes catalase (CAT), ascorbate peroxidase (APX), and superoxide dismutase (SOD) were also higher in “Sanguinello” and increased during storage. Overall, these results together with the sensory analysis suggested that “Sanguinello” would be the best cultivar for prolonged storage. The results of this study could be useful to select the best storage duration and temperature for each cultivar and provide the presence of such a high-value commodity for fresh consumption or juice processing long after the harvest season.
Anthocyanins from Purple Tomatoes as Novel Antioxidants to Promote Human Health
Authors: Gonzali Silvia , Perata Pierdomenico
Published: October 2020

Anthocyanins are plant secondary metabolites belonging to the class of polyphenols, whose beneficial roles in the prevention and treatment of several important human diseases have been demonstrated in many epidemiological studies. Their intake through diet strictly depends on the eating habits, as anthocyanins are contained in red and purple fruit and vegetables as well as in some processed foods and beverages, such as red wine. Genetic engineering and breeding programs have been recently carried out to increase the content of anthocyanins in candidate plant species which cannot offer satisfactory levels of these precious compounds. Tomato (Solanum lycopersicum) is a vegetable commodity where these strategies have resulted in success, leading to the production of new anthocyanin-rich fruit varieties, some of which are already marketed. These varieties produce purple fruits with a high nutraceutical value, combining the health benefits of the anthocyanins to the other classical tomato phytochemicals, particularly carotenoids. The antioxidant capacity in tomato purple fruits is higher than in non-anthocyanin tomatoes and their healthy role has already been demonstrated in both in vitro and in vivo studies. Recent evidence has indicated a particular capacity of tomato fruit anthocyanins to act as scavengers of harmful reactive chemical species and inhibitors of proliferating cancer cells, as well as anti-inflammatory molecules.
Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain
Authors: Mullins Caitlyn A. , Gannaban Ritchel B. , Khan Md Shahjalal , Shah Harsh , Siddik Md Abu B. , Hegde Vijay K. , Reddy P. Hemachandra , Shin Andrew C.
Published: October 2020

Obesity prevalence is increasing at an unprecedented rate throughout the world, and is a strong risk factor for metabolic, cardiovascular, and neurological/neurodegenerative disorders. While low-grade systemic inflammation triggered primarily by adipose tissue dysfunction is closely linked to obesity, inflammation is also observed in the brain or the central nervous system (CNS). Considering that the hypothalamus, a classical homeostatic center, and other higher cortical areas (e.g. prefrontal cortex, dorsal striatum, hippocampus, etc.) also actively participate in regulating energy homeostasis by engaging in inhibitory control, reward calculation, and memory retrieval, understanding the role of CNS oxidative stress and inflammation in obesity and their underlying mechanisms would greatly help develop novel therapeutic interventions to correct obesity and related comorbidities. Here we review accumulating evidence for the association between ER stress and mitochondrial dysfunction, the main culprits responsible for oxidative stress and inflammation in various brain regions, and energy imbalance that leads to the development of obesity. Potential beneficial effects of natural antioxidant and anti-inflammatory compounds on CNS health and obesity are also discussed.
A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases
Authors: Ramli Nur Zuliani , Yahaya Mohamad Fairuz , Tooyama Ikuo , Damanhuri Hanafi Ahmad
Published: October 2020

Nutraceuticals have been extensively studied worldwide due to its neuroprotective effects in in vivo and in vitro studies, attributed by the antioxidative properties. Alzheimer (AD) and Parkinson disease (PD) are the two main neurodegenerative disorders that are discussed in this review. Both AD and PD share the similar involvement of oxidative stress in their pathophysiology. Nutraceuticals exert their antioxidative effects via direct scavenging of free radicals, prevent damage to biomolecules, indirectly stimulate the endogenous antioxidative enzymes and gene expressions, inhibit activation of pro-oxidant enzymes, and chelate metals. In addition, nutraceuticals can act as modulators of pro-survival, pro-apoptotic, and inflammatory signaling pathways. They have been shown to be effective particularly in preclinical stages, due to their multiple mechanisms of action in attenuating oxidative stress underlying AD and PD. Natural antioxidants from food sources and natural products such as resveratrol, curcumin, green tea polyphenols, and vitamin E are promising therapeutic agents in oxidative stress-mediated neurodegenerative disease as they have fewer adverse effects, more tolerable, cheaper, and sustainable for long term consumption.
A Method for Building Service Process Value Model Based on Process Mining
Authors: Zhou Xuequan , Zacharewicz Gregory , Chen David , Chu Dianhui
Published: October 2020

With the emergence and development of servitization, more and more enterprises are turning from product focus to service focus. Service is customer-oriented, and driven by customer requirements. Value is the goal pursued by all actors in the service. In order to analyze the mechanism of multi-actor collaborative value creation in the service process, this paper proposes a method for building a service process value model, based on process mining. Driven by the raw data and an event log of service activities and processes in the real world, stored in the service system, the method uses process mining techniques and combines domain knowledge to describe the construction steps of the service process value model at the conceptual level. We focus on the specific processes and activities in the service, and mainly consider the value creation of the activity. The model proposed in this paper aims, to reflect how service actors co-create value in the actual execution of service processes, and to help service actors achieve their value goals. We use a case study inspired by an industrial case to validate our idea. Moreover, we develop a new plug-in, based on the α-algorithm for ProM, to realize the model construction in the case study.
Renewable Waste-to-Energy in Southeast Asia: Status, Challenges, Opportunities, and Selection of Waste-to-Energy Technologies
Authors: Tun Maw Maw , Palacky Petr , Juchelkova Dagmar , Síťař Vladislav
Published: October 2020

Rapid urban population growth that boosts increased waste generation and electricity demand has led to a possible alternative waste-to-energy solution in Southeast Asia. Despite some issues related to the development of the waste-to-energy sector such as public perception, all stakeholder involvement, public–private partnerships, funding, and climate factors, some Southeast Asian countries have made a reasonably successful step toward the developed technologies. Therefore, this study aimed to highlight an overview of the waste-to-energy sector in Southeast Asian countries to specify the status, challenges, opportunities, and selection of the technologies suited for the specific country. In order to achieve this aim, the study collected, synthesized, and evaluated data about waste resources, current waste management, waste-to-energy utilization, and its potential in the region based on published research papers and policy reports. It was found that the major waste-to-energy technologies in the region are incineration, landfills with gas capture, and anaerobic digestion. The total quantity of the waste-to-energy capacity from landfill biogas plants, incineration plants, and other waste-to-energy practices in the region accounts for over 323 MW at present and is expected to grow to double its current size by 2022. Meanwhile, by 2030, the realizable generation potential from renewable municipal waste in six Southeast Asian countries (Indonesia, Malaysia, Philippines, Singapore, Thailand, and Vietnam) amounts to 17.26 terawatt-hours (TWh). The study also specifies the requirements and considerations for the selection of waste-to-energy technologies, as well as the dimensions related to the development of the technologies. Additionally, four major aspects—technical, financial, environmental, and social and political—regarding the challenges and opportunities for the development of these technologies are considered. The challenges and opportunities related to the development of waste-to-energy in the region reveal how to overcome the drawbacks and to grasp the benefits at present and in the near future. Finally, the study is concluded with suggestions for the selection of the technologies in the region.
Tracking Robot Location for Non-Destructive Evaluation of Double-Shell Tanks
Authors: Cree Christopher , Carter Emily , Wang Heng , Mo Changki , Miller John
Published: October 2020

(1) Background: Non-destructive evaluation of double-shell nuclear-waste storage tanks at the U.S. Department of Energy’s Hanford site requires a robot to navigate a network of air slots in the confined space between primary and secondary tanks. Situational awareness, data collection, and data interpretation require continuous tracking of the robot’s location. (2) Methods: Robot location is continuously monitored using video image analysis for short distances and laser ranging for absolute location. (3) Results: The technique was demonstrated in our laboratory using a mockup of air slot and robot. (4) Conclusions: Location tracking and display provide decision support to inspectors and lay the groundwork for automated data collection.
A Robotic Calibration Method Using a Model-Based Identification Technique and an Invasive Weed Optimization Neural Network Compensator
Authors: Le Phu-Nguyen , Kang Hee-Jun
Published: October 2020

The study proposed a robotic calibration algorithm for improving the robot manipulator position precision. At first, the kinematic parameters as well as the compliance parameters of the robot can be identified together to improve its accuracy using the joint deflection model and the conventional kinematic model calibration technique. Then, an artificial neural network is constructed for further compensating the unmodeled errors. The invasive weed optimization is used to determine the parameters of the neural network. To show the advantages of the suggested technique, an HH800 robot is employed for the experimental study of the proposed algorithm. The improved position precision of the robot after the experiment firmly proves the practicability and positional precision of the proposed method over the other algorithms in comparison.
Localisation of Ancient Migration Pathways inside a Fractured Metamorphic Hydrocarbon Reservoir in South-East Hungary
Authors: M. Tóth Tivadar , Molnár László , Körmös Sándor , Czirbus Nóra , Schubert Félix
Published: October 2020

Numerous fractured hydrocarbon reservoirs exist in the metamorphic basement of the Pannonian Basin in Hungary. Many decades of experience in production have proven that these reservoirs are highly compartmentalised, resulting in a complex mosaic of permeable and impermeable domains situated next to each other. Consequently, in most fields, only a small amount of the total hydrocarbon reserve can be extracted. This paper aims to locate the potential migration pathways inside the most productive basement reservoir of the Pannonian Basin, using a multiscale approach. To achieve this, evaluation well-log data, DFN modelling and a composition analysis of fluid trapped in a vein-filling zeolite phase are combined. Data on a single well are presented as an example. The results of the three approaches indicate the presence of two highly fractured intervals separated by a barely fractured amphibolite. The two zones are probably part of the communicating fracture system inside the single metamorphic mass. The gas analysis further specifies the migrated fluids and indicates hydrocarbons of a composition similar to that of the recently produced oil. Consequently, we conclude that the two zones do not only form an ancient migration pathway but are also members of a more recent hydrocarbon system.
Plant-Growth-Promoting Bacteria Mitigating Soil Salinity Stress in Plants
Authors: Shilev Stefan
Published: October 2020

Soil deterioration has led to problems with the nutrition of the world’s population. As one of the most serious stressors, soil salinization has a negative effect on the quantity and quality of agricultural production, drawing attention to the need for environmentally friendly technologies to overcome the adverse effects. The use of plant-growth-promoting bacteria (PGPB) can be a key factor in reducing salinity stress in plants as they are already introduced in practice. Plants having halotolerant PGPB in their root surroundings improve in diverse morphological, physiological, and biochemical aspects due to their multiple plant-growth-promoting traits. These beneficial effects are related to the excretion of bacterial phytohormones and modulation of their expression, improvement of the availability of soil nutrients, and the release of organic compounds that modify plant rhizosphere and function as signaling molecules, thus contributing to the plant’s salinity tolerance. This review aims to elucidate mechanisms by which PGPB are able to increase plant tolerance under soil salinity.
Influence of Radar and Gauge Rainfall Data Sources on the Analysis of Spatial Distribution of Traffic Accidents and Rainfall Events
Authors: Yoon Seong-Sim , Ji Un , Bae Inhyeok
Published: October 2020

The records of 24,797 traffic accidents (9039 involving fatalities or severe injury) during rainy conditions from 2007 to 2017 in Seoul, South Korea, were used to analyze the spatial distribution of the traffic accidents and rainfall events based on radar and gauge rainfall data. According to the spatial correspondence analysis between rainfall distribution and accident locations for localized and stratiform rain events, radar data in a two-dimensional grid (250 by 250 m) of 10 min temporal resolution benefited the localized rainfall distribution concerning the accident location. The relative accident rate (RAR) from radar data, which was used as a quantitative reference value for the effect of rainfall on traffic accidents, was about 18% higher than that from gauge rainfall. The radar data more clearly classified the number of traffic accidents during rainy conditions because its spatial distribution was more precise for all accidents. In addition, the RAR estimation of accidents involving fatalities and severe injury during rainfall could provide information on the district in which traffic accidents increase due to rainfall. The study results support the adoption of radar-derived rainfall data to analyze the influence of rainfall on accidents and the development of more accurate risk-assessment tools for drivers and planners.
Treatment Strategy of Transarterial Chemoembolization for Hepatocellular Carcinoma
Authors: Miyayama Shiro
Published: October 2020

Transarterial chemoembolization (TACE) is a first-line treatment for patients with hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer stage B (BCLC-B). There are two major techniques of TACE: conventional TACE (cTACE) using iodized oil and gelatin sponge particles, and TACE using drug-eluting beads (DEB-TACE). The latest randomized controlled trial proved the superiority of cTACE regarding local effects over DEB-TACE; however, cTACE also damages the liver more severely. Therefore, cTACE should be performed for localized HCCs as selectively as possible. On the other hand, DEB-TACE has less liver toxicity and is favorable for patients with an advanced age, large and/or bilobar tumors, or a poor liver function. However, some BCLC-B HCCs are TACE-resistant and the concept of TACE unsuitability (mainly up-to-7 criteria out) has been proposed by Asia-Pacific Primary Liver Cancer Expert Meeting. Systemic therapy is recommended for patients with TACE-unsuitable HCC; however, the condition of TACE-unsuitable HCC does not always rule out TACE monotherapy and some up-to-7 criteria out tumors may also be good candidates for superselective cTACE when localized in limited liver segments. The sequential therapy of an antiangiogenic and TACE is also a novel option for patients with TACE-unsuitable HCC, antiangiogenic-refractory HCC, or even down-staged HCC.
An Enhanced Adaptive Block Truncation Coding with Edge Quantization Scheme
Authors: Yang Ching-Nung , Chou Yung-Chien , Chang Tao-Ku , Kim Cheonshik
Published: October 2020

Recently, image compression using adaptive block truncation coding based on edge quantization (ABTC-EQ) was proposed by Mathews and Nair. Their approach deals with an image for two types of blocks, edge blocks and non-edge blocks. Different from using the bi-clustering approach on all blocks in previous block truncation coding (BTC)-like schemes, ABTC-EQ adopts tri-clustering to tackle edge blocks. The compression ratio of ABTC-EQ is reduced, but the visual quality of the reconstructed image is significantly improved. However, it is observed that ABTC-EQ uses 2 bits to represent the index of three clusters in a block. We can only use an average of 5/3 bits by variable-length code to represent the index of each cluster. On the other hand, there are two observations on the quantization levels in a block. The first observation is that the difference between the two quantization values is often smaller than the quantization values themselves. The second observation is that more clusters may enhance the visual quality of the reconstructed image. Based on variable-length coding and the above observations, we design variants of ABTC-EQ to enhance the visual quality of the reconstructed image and compression ratio.
Improving Low Frequency Isolation Performance of Optical Platforms Using Electromagnetic Active-Negative-Stiffness Method
Authors: Zhao Yamin , Cui Junning , Zhao Junchao , Bian Xingyuan , Zou Limin
Published: October 2020

To improve the low-frequency isolation performance of optical platforms, an electromagnetic active-negative-stiffness generator (EANSG) was proposed, using nano-resolution laser interferometry sensors to monitor the micro-vibration of an optical platform, and precision electromagnetic actuators integrated with a relative displacement feedback strategy to counteract the positive stiffness of pneumatic springs within a micro-vibration stroke, thereby producing high-static-low-dynamic stiffness characteristics. The effectiveness of the method was verified by both theoretical and experimental analyses. The experimental results show that the vertical natural frequency of the optical platform was reduced from 2.00 to 1.37 Hz, the root mean square of displacement was reduced from 1.28 to 0.69 μm, and the root mean square of velocity was reduced from 14.60 to 9.33 μm/s, proving that the proposed method can effectively enhance the low frequency isolation performance of optical platforms.
Mineralization of Biomaterials for Bone Tissue Engineering
Authors: Wu Xinchen , Walsh Kierra , Hoff Brianna L. , Camci-Unal Gulden
Published: October 2020

Mineralized biomaterials have been demonstrated to enhance bone regeneration compared to their non-mineralized analogs. As non-mineralized scaffolds do not perform as well as mineralized scaffolds in terms of their mechanical and surface properties, osteoconductivity and osteoinductivity, mineralization strategies are promising methods in the development of functional biomimetic bone scaffolds. In particular, the mineralization of three-dimensional (3D) scaffolds has become a promising approach for guided bone regeneration. In this paper, we review the major approaches used for mineralizing tissue engineering constructs. The resulting scaffolds provide minerals chemically similar to the inorganic component of natural bone, carbonated apatite, Ca5(PO4,CO3)3(OH). In addition, we discuss the characterization techniques that are used to characterize the mineralized scaffolds, such as the degree of mineralization, surface characteristics, mechanical properties of the scaffolds, and the chemical composition of the deposited minerals. In vitro cell culture studies show that the mineralized scaffolds are highly osteoinductive. We also summarize, based on literature examples, the applications of 3D mineralized constructs, as well as the rationale behind their use. The mineralized scaffolds have improved bone regeneration in animal models due to the enhanced mechanical properties and cell recruitment capability making them a preferable option for bone tissue engineering over non-mineralized scaffolds.
The Relationship between Carotid Doppler Ultrasound and EEG Metrics in Healthy Preschoolers and Adults
Authors: Portnova Galina V. , Maslennikova Aleksandra V. , Proskurnina Elena V.
Published: October 2020

Despite widespread using electroencephalography (EEG) and Doppler ultrasound in pediatric neurology clinical practice, there are still no well-known correlations between these methods that could contribute to a better understanding of brain processes and development of neurological pathology. This study aims to reveal relationship between EEG and Doppler ultrasound methods. We compared two cohorts of adults and preschool children with no history of neurological or mental diseases. The data analysis included investigation of EEG and carotid blood flow indexes, which are significant in neurological diagnosis, as well as calculation of linear and non-linear EEG parameters and ratios between the systolic peak velocities of carotid arteries and carotid blood asymmetry. We have found age-dependent correlations between EEG and power Doppler ultrasound imaging (PDUI) data. Carotid blood flow asymmetry correlated with delta-rhythm power spectral density only in preschoolers. The ratios of blood flow velocities in the internal carotid arteries to those in the common carotid arteries correlated with higher peak alpha frequency and lower fractal dimension; moreover, they were associated with lower Epworth sleepiness scale scores. The study revealed significant correlations between EEG and PDUI imaging indexes, which are different for healthy children and adults. Despite the fact that the correlations were associated with non-clinical states such as overwork or stress, we assumed that the investigated parameters could be applicable for clinical trials.
Comprehensive Analysis of Tumour Sub-Volumes for Radiomic Risk Modelling in Locally Advanced HNSCC
Authors: Leger Stefan , Zwanenburg Alex , Leger Karoline , Lohaus Fabian , Linge Annett , Schreiber Andreas , Kalinauskaite Goda , Tinhofer Inge , Guberina Nika , Guberina Maja , Balermpas Panagiotis , von der Grün Jens , Ganswindt Ute , Belka Claus , Peeken Jan C. , Combs Stephanie E. , Boeke Simon , Zips Daniel , Richter Christian , Krause Mechthild , Baumann Michael , Troost Esther G.C. , Löck Steffen
Published: October 2020

Imaging features for radiomic analyses are commonly calculated from the entire gross tumour volume (GTVentire). However, tumours are biologically complex and the consideration of different tumour regions in radiomic models may lead to an improved outcome prediction. Therefore, we investigated the prognostic value of radiomic analyses based on different tumour sub-volumes using computed tomography imaging of patients with locally advanced head and neck squamous cell carcinoma. The GTVentire was cropped by different margins to define the rim and the corresponding core sub-volumes of the tumour. Subsequently, the best performing tumour rim sub-volume was extended into surrounding tissue with different margins. Radiomic risk models were developed and validated using a retrospective cohort consisting of 291 patients in one of the six Partner Sites of the German Cancer Consortium Radiation Oncology Group treated between 2005 and 2013. The validation concordance index (C-index) averaged over all applied learning algorithms and feature selection methods using the GTVentire achieved a moderate prognostic performance for loco-regional tumour control (C-index: 0.61 ± 0.04 (mean ± std)). The models based on the 5 mm tumour rim and on the 3 mm extended rim sub-volume showed higher median performances (C-index: 0.65 ± 0.02 and 0.64 ± 0.05, respectively), while models based on the corresponding tumour core volumes performed less (C-index: 0.59 ± 0.01). The difference in C-index between the 5 mm tumour rim and the corresponding core volume showed a statistical trend (p = 0.10). After additional prospective validation, the consideration of tumour sub-volumes may be a promising way to improve prognostic radiomic risk models.
A Multi-Enzyme Cascade for the Production of High-Value Aromatic Compounds
Authors: Engelmann Claudia , Johannsen Jens , Waluga Thomas , Fieg Georg , Liese Andreas , Bubenheim Paul
Published: October 2020

Cascade reactions are the basis of life in nature and are adapted to research and industry in an increasing manner. The focus of this study is the production of the high-value aromatic ester cinnamyl cinnamate, which can be applied in flavors and fragrances. A three-enzyme cascade was established to realize the synthesis, starting from the corresponding aldehyde with in situ cofactor regeneration in a two-phase system. After characterization of the enzymes, a screening with different organic solvents was carried out, whereby xylene was found to be the most suitable solvent for the second phase. The reaction stability of the formate dehydrogenase (FDH) from Candida boidinii is the limiting step during cofactor regeneration. However, the applied enzyme cascade showed an overall yield of 54%. After successful application on lab scale, the limitation by the FDH was overcome by immobilization of the enzymes and an optimized downstream process, transferring the cascade into a miniplant. The upscaling resulted in an increased yield for the esterification, as well as overall yields of 37%.
Clock-Controlled Mitochondrial Dynamics Correlates with Cyclic Pregnenolone Synthesis
Authors: Witzig Melissa , Grimm Amandine , Schmitt Karen , Lejri Imane , Frank Stephan , Brown Steven A. , Eckert Anne
Published: October 2020

Neurosteroids are steroids synthetized in the nervous system, with the first step of steroidogenesis taking place within mitochondria with the synthesis of pregnenolone. They exert important brain-specific functions by playing a role in neurotransmission, learning and memory processes, and neuroprotection. Here, we show for the first time that mitochondrial neurosteroidogenesis follows a circadian rhythm and correlates with the rhythmic changes in mitochondrial morphology. We used synchronized human A172 glioma cells, which are steroidogenic cells with a functional core molecular clock, to show that pregnenolone levels and translocator protein (TSPO) are controlled by the clock, probably via circadian regulation of mitochondrial fusion/fission. Key findings were recapitulated in mouse brains. We also showed that genetic or pharmacological abrogation of fusion/fission activity, as well as disturbing the core molecular clock, abolished circadian rhythms of pregnenolone and TSPO. Our findings provide new insights into the crosstalk between mitochondrial function (here, neurosteroidogenesis) and circadian cycles.
Attitude towards People with Disability of Nursing and Physiotherapy Students
Authors: Oliva Ruiz Petronila , Gonzalez-Medina Gloria , Salazar Couso Alejandro , Jiménez Palomares María , Rodríguez Mansilla Juan , Garrido Ardila Elisa María , Merchan Vicente María Nieves
Published: October 2020

Background: Attitudes are a component of our behaviour. Health professionals should have a global perspective of disability. They must provide treatment to people with disability and care for them, but they also should accept them with no judgements or discrimination. The general objective of this study was to know the attitude towards people with disability of nursing and physiotherapy students at the University of Cadiz. Methods: This was a descriptive, correlational, transversal and synchronous study. A total of 200 students participated in the study (91 from the bachelor’s degree in nursing and 109 from the bachelor’s degree in physiotherapy). The ‘Attitudes towards people with disability scale’ was used. Results: The mean score for both groups of students was 157.05 (SD = 14.14). Conclusions: Attitudes towards disability of nursing and physiotherapy students at the University of Cadiz tend to be positive. However, this was considered not sufficient since they will be health professionals in the future.
Climate-Friendly Ethics Prescribed by Top World Airlines: Empirical Evidence
Authors: Ruban Dmitry A. , Yashalova Natalia N.
Published: October 2020

The aviation industry contributes substantially to the global climate change, and, thus, airline companies need development of climate-friendly ethics. The content of the codes of conduct of 16 airline companies boasting either the greatest number of daily departures or the largest air fleet (or both) are analyzed. It is established that 25% of these companies prescribe climate-friendly behavior often focusing on emissions. Moreover, many other companies prescribe pro-environmental behavior. The situation seems to be promising, although improvements of the existing corporate ethical prescriptions are necessary. Despite its tentative character and certain limitations, this study permits putting the climate-friendly ethics of airlines on the international agenda. Practically, it is important to add climate-related notions to those codes of conduct where these do not exist and to use successful examples as ethical templates for the entire aviation industry.
New Low-Voltage Driving Compensating Pixel Circuit Based on High-Mobility Amorphous Indium-Zinc-Tin-Oxide Thin-Film Transistors for High-Resolution Portable Active-Matrix OLED Displays
Authors: Fan Ching-Lin , Tsao Hou-Yen , Chen Chun-Yuan , Chou Pei-Chieh , Lin Wei-Yu
Published: October 2020

In recent years, active-matrix organic light-emitting diodes (AMOLEDs) has been the most popular display for portable application. To satisfy the requirement for the application of the portable display, the design of the compensating pixel circuit with the low-voltage driving and low-power consumption will be requested. In addition to the circuit with the design of the low-voltage driving, high-mobility thin-film transistors as driving device will be also necessary in order to supply larger driving current at low-voltage driving. Therefore, the study presents a new low-voltage driving AMOLED pixel circuit with high-mobility amorphous indium–zinc–tin–oxide (a-IZTO) thin-film transistors (TFTs) as driving device for portable displays with high resolution. The proposed pixel circuit can simultaneously compensate for the threshold voltage variation of driving TFT (ΔVTH_TFT), OLED degradation (ΔVTH_OLED), and the I-R drop of a power line (ΔVDD). By using AIM-Spice for simulation based on fabricated a-IZTO TFTs with mobility of 70 cm2V−1S−1 as driving devices, we discovered that the error rates of the driving current were all lower than 5.71% for all input data when ΔVTH_TFT = ±1 V, ΔVDD = 0.5 V, and ΔVTH_OLED = 0.5 V were all considered simultaneously. We revealed that the proposed 5T2C pixel circuit containing a high-mobility a-IZTO TFT as a driving device was suitable for high-resolution portable displays.
Post-Mortem Investigations for the Diagnosis of Sepsis: A Review of Literature
Authors: Stassi Chiara , Mondello Cristina , Baldino Gennaro , Ventura Spagnolo Elvira
Published: October 2020

To date, sepsis is still one of the most important causes of death due to the difficulties concerning the achievement of a correct diagnosis. As well as in a clinical context, also in a medico-legal setting the diagnosis of sepsis can reveal challenging due to the unspecificity of the signs detected during autopsies, especially when no ante-mortem clinical data, laboratory, and cultural results are available. Thus, a systematic review of literature was performed to provide an overview of the main available and updated forensic tools for the post-mortem diagnosis of sepsis. Moreover, the aim of this review was to evaluate whether a marker or a combination of markers exist, specific enough to allow a correct and definite post-mortem diagnosis. The review was conducted searching in PubMed and Scopus databases, and using variable combinations of the keywords “post mortem sepsis diagnosis”, “macroscopic signs”, “morphology”, “histology”, “immunohistochemical markers”, “biochemical markers”, and “forensic microbiology”. The article selection was carried out following specific inclusion and exclusion criteria. A total of 44 works was identified, providing data on morphological aspects of the organs examined, histological findings, immunohistochemical and biochemical markers, and cultural assays. The review findings suggested that the post-mortem diagnosis of sepsis can be achieved by a combination of data obtained from macroscopic and microscopic analysis and microbial investigations, associated with the increased levels of at least two of three biochemical and/or immunohistochemical markers evaluated simultaneously on blood samples.
Unifying Aspects of Generalized Calculus
Authors: Czachor Marek
Published: October 2020

Non-Newtonian calculus naturally unifies various ideas that have occurred over the years in the field of generalized thermostatistics, or in the borderland between classical and quantum information theory. The formalism, being very general, is as simple as the calculus we know from undergraduate courses of mathematics. Its theoretical potential is huge, and yet it remains unknown or unappreciated.
A Socio-Economic Model of Sales Tax Compliance
Authors: Alshira’h Ahmad Farhan , Alsqour Moh’d , Lutfi Abdalwali , Alsyouf Adi , Alshirah Malek
Published: October 2020

Tax compliance is an issue that can be traced back to the introduction of taxes, which is the reason such compliance remains a significant topic in the current literature of academia and practice. Prior studies on the topic of tax compliance or non-compliance can be categorized into two, namely economic and social/psychological theories. In a more serious note, tax evasion has remained a key issue among governments all over the globe, with Jordan being no exception. Jordan has undertaken different fiscal measures to increase compliance in the domestic front in the past decades, but based on annual reports, the country is still experiencing a considerable increase in net public debt and fiscal deficit that can be traced back to the increased tax non-compliance rate. This is specifically true in the case of sales tax in Jordan. To compound the matter further, literature concerning the determinants of sales tax compliance as well as other determinants that drive non-compliance is still scarce, with a universal tax compliance model able to explain the issue with clarity still being elusive. Hence, this work proposed the determinants of sales tax compliance in the context of small and medium-sized enterprises (SMEs) in Jordan, extending Fischer’s model of tax compliance, and adding the moderating role of tax knowledge and direct effect of tax service quality. This study proposed a model encapsulating the social, psychological and economic factors to provide insight into the sales tax compliance of Jordanian SMEs.
Optimization Design of Rib Width and Performance Analysis of Solid Oxide Electrolysis Cell
Authors: Guo Meiting , Ru Xiao , Lin Zijing , Xiao Guoping , Wang Jianqiang
Published: October 2020

Structure design is of great value for the performance improvement of solid oxide electrolysis cells (SOECs) to diminish the gap between scientific research and industrial application. A comprehensive multi-physics coupled model is constructed to conduct parameter sensitivity analysis to reveal the primary and secondary factors on the SOEC performance and optimal rib width. It is found that the parameters of the O2 electrode have almost no influence on the optimal rib width at the H2 electrode side and vice versa. The optimized rib width is not sensitive to the electrode porosity, thickness, electrical conductivity and gas composition. The optimal rib width at the H2 electrode side is sensitive to the contact resistance at the interface between the electrode and interconnect rib, while the extremely small concentration loss at the O2 electrode leads to the insensitivity of optimal rib width to the parameters influencing the O2 diffusion. In addition to the contact resistance, the applied cell voltage and pitch width also has a dramatic influence on the optimal rib width of the fuel electrode. An analytical expression considering the influence of total cell polarization loss, the pitch width and the contact resistance is further developed for the benefit of the engineering society. The maximum error in the cell performance between the numerically obtained and analytically acquired optimal rib width is only 0.14% and the predictive power of the analytical formula is fully verified.
Numerical Simulation for Void Coalescence (Water Treeing) in XLPE Insulation of Submarine Composite Power Cables
Authors: Drissi-Habti Monssef , Raj-Jiyoti Das , Vijayaraghavan Soumianarayanan , Fouad Ech-Cheikh
Published: October 2020

Due to the growing demand for offshore renewable energy, the development of durable submarine power cables is critical. Submarine power cables are expected to have a service life of over 20 years. However, it has been shown that these cables suffer from water-tree flaws that progressively extend to conductors and corrode copper, which may lead to premature failure. Water treeing is caused by the of interconnection of voids (of a few nanometers) that are present in the insulator after manufacturing or formed during operation. The economic consequences of a breakdown can be drastic due to the heavy maintenance required. In the current study, the insulator is modelled as cubic unit cells containing water voids in the form of ellipsoids. The displacement field of ellipsoids is found to be dependent on its distribution in the cubic cell and on the applied electric field. Von Mises stress and effective plastic strain at the tips of the ellipsoid are found to be significant when either the relative distance between the two ellipsoids is short or the applied electric field is high. The proposed model is intended to provide insights into the ageing of cross-linked polyethylene (XPLE), which is extremely difficult to predict experimentally due to the excessive time needed to achieve coalescence of voids.
Conditions of the Occurrence of the Environmental Kuznets Curve in Agricultural Production of Central and Eastern European Countries
Authors: Kułyk Piotr , Augustowski Łukasz
Published: October 2020

The article examines the relationship between CO2 equivalent emissions and agricultural production, taking into account additional economic and social variables that correct the considered relationship for the six Central and Eastern European countries over the period 1992–2017. The aim of the article was to confirm or negate the occurrence of the environmental Kuznets curve (EKC) in the countries of Central and Eastern Europe. Countries that experienced a political transformation and were subsequently admitted to the European Union (EU) undergoing a preparatory period were included. The topic is timely as all EU countries are required to monitor their emissions under the EU Climate Monitoring Mechanism. The discussed problem is significant due to the changes taking place in the common agricultural policy, the choice of actions to be taken by individual countries in their national policies, and the choice of instruments to support the transformation of agriculture. Agriculture has a particularly large impact on emissions, especially N2O and CH4. This paper uses GLS (Generalized least squares) panel regression with random effects taking into consideration individual effects for countries. The conducted empirical research confirmed the hypothesis regarding the occurrence of the Kuznets curve in relation to agricultural production. In this situation, it is required to increase the activities of maintaining production growth, with the support of technological changes that significantly increase pro-environmental conditions, because, in the current circumstances, this growth takes place with an increase in CO2 gas emissions, thus leading to negative external effects.