bluuebunny/crossref_metadata_2025 huggingface dataset:
Indoor Navigation and Tourist Guide Using Augumented Reality
Authors:   Department of Computer Science and Engineering, V.S.B College of Engineering Technical Campus, Coimbatore,Tamilnadu, India., N Nikil , P Dinesh Kumar
Published: May 2023

The suggested project is based on augmented reality concepts for indoor route innovation. When travelling to a remote location, you can use a g-map to navigate outside, but when it comes to the interior, you are left in the dark and helpless. Here is our service that allows you to travel within a faraway city to an open area where you can receive our aid with the improvement of augmented reality. Our app uses augmented reality (AR) images to point users in the right direction inside. For instance, if you received confirmation from a college while travelling there, you don't need to wait for the inside navigation to be completed. It was secured by us. Our suggested strategy will enable you to move freely within the college grounds.
Speech to Sign Language Converter & Vice Versa Using Machine Learning
Authors:   Department of Computer Science and Engineering, Institute of Technology and Management Gorakhpur, Uttar Pradesh, India., Sahu Khushi , Mishra Kirti , Rai Mridul
Published: May 2023

Taking into account the complications faced by pupils of speech and hearing impaired, we would like to present a tool that connects the gap in communication and facilitate better interaction. In situations where a spoken person is untrained with sign language, the need is unavoidable for a sign language interpreter in order to setup an interchange of expounding. We propose a system that allows two-way conversation between deaf people and people with other voices. In this paper, we present an efficient prototype in two stages. In the early stages, sign language gestures are fed into the system in real time using the device's computer vision capabilities. These gestures are then recognized using our Deep Neural Network while the fine-tuned hand detection with edge detection algorithm interprets it as text as well as audio. The second stage is to convert the audio to text and optionally display the relevant hand gestures for the same The system can recognize more than 300 sign words in Indian Sign Language. .Key Word: Concurrent Neural Networks, Natural Language Processing, Machine Learning, Sign Language Converter, Computer Vision
Metode Penetapan Mustahiq Zakat Pada Mustahiq Center Baznas Kabupaten Wonosobo
Authors: Anwar Choerul , Handoyo Handoyo
Published: May 2023

This paper will analyze the method of determining mustahiq zakat through the mustahiq center at BAZNAS Wonosobo Regency. In this study the writer will use a qualitative approach with descriptive methods. The data source used is the method of determining mustahiq zakat through the mestahiq center used by the Wonosobo National Amil Zakat Agency (BAZNAS). The results of this study can be concluded that the National Amil Zakat Agency (BAZNAS) of Wonosobo Regency in determining mustahiq zakat by developing an integrated national Mustahiq database system (Mustahiq Data Center). This system is presented in an effort to sharpen the target of zakat recipients by utilizing existing poverty data in Wonosobo district.
Das Jungneolithikum in Schleswig-Holstein
Authors: Schultrich Sebastian
Published: May 2023

This book offers a comprehensive study of the Younger Neolithic period ([YN], c. 2850 – 2250 BC) of Schleswig-Holstein (SH). Apart from presenting all currently known artefacts and contexts of that period in detail, a particular focus was placed on the examination of YN battle axes. They appear to be the most common artefact that is preserved from the YN, and they are very well suited for investigating social phenomena. These artefacts furthermore changed diachronically. While battle axes of the early stage are shaped more or less equally elaborately, late specimens exhibit significant morphological variation and difference, as some specimens were shaped very elaborately whereas others were quite simple. The same difference has been observed for the subsequently used flint daggers. It is suggested that this difference reflects the emergence of a more stratified society. Many battle axes appear to have been deposited as broken pieces. As the ratio of cutting edges to butt ends is unequal (2:1) both in SH and in a wider region and as many pieces have “decorations” (Applikationen, pars pro toto shaft holes), battle axes are regarded as intentionally deposited. Accordingly, a large proportion of single finds are regarded as intentional depositions. Another focus was set on examining the transition to the YN. It is argued that many aspects that are said to characterize the YN are rooted in the preceding Middle Neolithic. A novelty is that social role becomes marked in funerary contexts. Thus, the transformation to the YN marks a certain point where already initiated societal changes become visible for first time. The examination of certain attributes revealed furthermore that there are differences between western and eastern SH which are not determined by chronological changes only. Rather, general differences appear between western and eastern regions, an in a wider geographical as well as temporal frame, which might be linked to different social orientations – either collectively or individually acting groups.
Conhecimentos de comunidades tradicionais e quilombolas sobre a pesca artesanal: estado da questão
Authors: Abreu Carem Cristini Nobre de , Reis Maria Clareth Gonçalves
Published: May 2023

A pesca artesanal e os quilombos integram o universo de 28 atividades socioeconômicas e culturais que compõem as comunidades tradicionais brasileiras. Buscamos neste artigo identificar o seguinte estado da questão: quais são os temas, os sujeitos das pesquisas, onde estão situadas as comunidades pesquisadas e quais foram os conceitos utilizados para compreender as temáticas dos estudos acadêmicos sobre a pesca artesanal relacionados com os quilombos e as comunidades tradicionais? Os dados analisados foram obtidos nos resumos dos estudos de pós-graduação, constantes no Catálogo de Teses e Dissertações da CAPES, no qual identificamos 368 pesquisas resultantes das buscas “pesca artesanal AND quilombola” (40) e “pesca artesanal AND comunidades tradicionais” (328). Diante de tal universo, nos interessamos em analisar um escopo de 70 estudos finalizados entre 2012 a 2021, divididos em duas grandes áreas de conhecimento: multidisciplinar e ciências humanas. Após o uso de critérios de seleção e descarte definidos, o recorte temático final que constitui um corpus de análise do presente estudo foi formado por 17 pesquisas: quatro teses e 13 dissertações. Resultam dessa análise a identificação de sete comunidades quilombolas, cinco comunidades tradicionais da pesca artesanal, quatro estudos de caso e 67 conceitos/grupo de conceitos trabalhados em 13 áreas do conhecimento científico: Antropologia, Ciências Sociais, Educação, Educação e Contemporaneidade, Educação e Cultura, Linguagens e Representações, Cognição e Linguagem, Desenvolvimento Social, Direto Ambiental e Políticas Públicas, Políticas Públicas, Estratégias e Desenvolvimento, Políticas Sociais e Sociologia Política.
The Students' Guide to Learning Design and Research
Authors: Kimmons Royce , Caskurlu Secil
Published: May 2023

Written by students for students, this book is a continually-evolving class project for students of educational technology, learning, and instructional design.
Rapid Academic Writing
Authors: Kimmons Royce , West Richard
Published: May 2023

This book provides a primer on several aspects of academic writing.
Foundations of Learning and Instructional Design Technology
Authors: West Richard
Published: May 2023

This book received the 2018 AECT Outstanding Book Award!
"What is this field?" "Where have we come from as a discipline, and where are we going?" "What do I want to study?"These and other questions are typical for new students in the field of Learning and Instructional Design Technology. This textbook is designed to help answer these questions and provide the quickest route to understanding the history and current trends in the field. After surveying classic theories and writings, as well as more recent applications of theory and practice, students will be better prepared to chart their own course and careers within the discipline. This book is designed to support foundations courses common in departments, as well as seminars on current trends and issues.
Design for Learning
Authors: McDonald Jason , West Richard
Published: May 2023

Our purpose in this book is twofold. First, we introduce the basic skill set and knowledge base used by practicing instructional designers. We do this through chapters contributed by experts in the field who have either academic, research-based backgrounds, or practical, on-the-job experience (or both). Our goal is that students in introductory instructional design courses will be able to use this book as a guide for completing a basic instructional design project. We also hope the book is useful as a ready resource for more advanced students or others seeking to develop their instructional design knowledge and skills.
Preface
Authors: Selimovic Amina
Published: May 2023

Preface
Introduction
Authors: Bøe Marianne Hafnor , Jakku Nina , Jensen Pernille Friis
Published: May 2023

Gender is a primary key for understanding Islam and Muslims in present day Scandinavia. Through norms and regulations, gender has proven inherent to how Islam is governed, perceived, and debated in public, but also pivotal for how Scandinavian Muslims understand, practice and negotiate their own religion. Moreover, the correlation between gender and Islam is a topic addressed by an increasing number of researchers in the Scandinavian countries. In this special issue of the Scandinavian Journal of Islamic Studies, we have gathered a selection of the ongoing research in this field. The articles included here, offer a peak into some of the currents in the highly diverse and emerging research field gender and Islam in Scandinavia. They also give an idea of the breadth of topics, disciplines, approaches and perspectives involved in such studies.
Le droit des individus d’appartenir à une communauté ou une nation et le droit réciproque du peuple autochtone de déterminer son régime de citoyenneté
Authors: Motard Geneviève , Picard Alexane
Published: May 2023

Ce texte examinera les dispositions de la DNUDPA touchant l’appartenance à une communauté ou à un peuple autochtone. Le droit de définir la composition d’un groupe étant une expression du droit à l’autodétermination, nous explorerons de quelles manières se manifestent les différents processus menant à la définition du groupe et à la saisie de l’identité autochtone par le droit au Canada. Il est ainsi conclu que l’apport de la DNUDPA est de soutenir les efforts des peuples et communautés autochtones cherchant à redéfinir leurs citoyennetés par les mécanismes de leur choix.
Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations
Authors: Lauterbur M. Elise , Cavassim Maria Izabel A. , Gladstein Ariella L. , Gower Graham , Pope Nathaniel S. , Tsambos Georgia , Adrion Jeff , Belsare Saurabh , Biddanda Arjun , Caudill Victoria , Cury Jean , Echevarria Ignacio , Haller Benjamin C. , Hasan Ahmed R. , Huang Xin , Iasi Leonardo Nicola Martin , Noskova Ekaterina , Obšteter Jana , Pavinato Vitor Antonio Corrêa , Pearson Alice , Peede David , Perez Manolo F. , Rodrigues Murillo F. , Smith Chris C. R. , Spence Jeffrey P. , Teterina Anastasia , Tittes Silas , Unneberg Per , Vazquez Juan Manuel , Waples Ryan K. , Wohns Anthony Wilder , Wong Yan , Baumdicker Franz , Cartwright Reed A. , Gorjanc Gregor , Gutenkunst Ryan N. , Kelleher Jerome , Kern Andrew D. , Ragsdale Aaron P. , Ralph Peter L. , Schrider Daniel R. , Gronau Ilan
Published: May 2023

Simulation is a key tool in population genetics for both methods development and empirical research, but producing simulations that recapitulate the main features of genomic data sets remains a major obstacle. Today, more realistic simulations are possible thanks to large increases in the quantity and quality of available genetic data, and to the sophistication of inference and simulation software. However, implementing these simulations still requires substantial time and specialized knowledge. These challenges are especially pronounced for simulating genomes for species that are not well-studied, since it is not always clear what information is required to produce simulations with a level of realism sufficient to confidently answer a given question. The community-developed framework stdpopsim seeks to lower this barrier by facilitating the simulation of complex population genetic models using up-to-date information. The initial version of stdpopsim focused on establishing this framework using six well-characterized model species (Adrion et al., 2020). Here, we report on major improvements made in the new release of stdpopsim (version 0.2), which includes a significant expansion of the species catalog and substantial additions to simulation capabilities. Features added to improve the realism of the simulated genomes include non-crossover recombination and provision of species-specific genomic annotations. Through community-driven efforts, we expanded the number of species in the catalog more than three-fold and broadened coverage across the tree of life. During the process of expanding the catalog, we have identified common sticking points and developed best practices for setting up genome-scale simulations. We describe the input data required for generating a realistic simulation, suggest good practices for obtaining the relevant information from the literature, and discuss common pitfalls and major considerations. These improvements to stdpopsim aim to further promote the use of realistic whole-genome population genetic simulations, especially in non-model organisms, making them available, transparent, and accessible to everyone.
A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila
Authors: Oikawa Izumi , Kondo Shu , Hashimoto Kao , Yoshida Akiho , Hamajima Megumi , Tanimoto Hiromu , Furukubo-Tokunaga Katsuo , Honjo Ken
Published: May 2023

Nociception is a neural process that animals have developed to avoid potentially tissue-damaging stimuli. While nociception is triggered in the peripheral nervous system, its modulation by the central nervous system is a critical process in mammals, whose dysfunction has been extensively implicated in chronic pain pathogenesis. The peripheral mechanisms of nociception are largely conserved across the animal kingdom. However, it is unclear whether the brain-mediated modulation is also conserved in non-mammalian species. Here, we show that
Drosophila
has a descending inhibitory mechanism of nociception from the brain, mediated by the neuropeptide Drosulfakinin (DSK), a homolog of cholecystokinin (CCK) that plays an important role in the descending control of nociception in mammals. We found that mutants lacking
dsk
or its receptors are hypersensitive to noxious heat. Through a combination of genetic, behavioral, histological, and Ca
2+
imaging analyses, we subsequently revealed neurons involved in DSK-mediated nociceptive regulation at a single-cell resolution and identified a DSKergic descending neuronal pathway that inhibits nociception. This study provides the first evidence for a descending modulatory mechanism of nociception from the brain in a non-mammalian species that is mediated by the evolutionarily conserved CCK system, raising the possibility that the descending inhibition is an ancient mechanism to regulate nociception.
Back to the future: omnipresence of fetal influence on the human brain through the lifespan
Authors: Walhovd Kristine B. , Krogsrud Stine Kleppe , Amlien Inge K. , Sørensen Øystein , Wang Yunpeng , Bråthen Anne Cecilie Sjøli , Overbye Knut , Kransberg Jonas , Mowinckel Athanasia M. , Magnussen Fredrik , Herud Martine , Håberg Asta K. , Fjell Anders M. , Vidal-Piñeiro Didac
Published: May 2023

Human fetal development has been associated with brain health at later stages. It is unknown whether growth in utero, as indexed by birth weight (BW), relates consistently to lifespan brain characteristics and changes, and to what extent these influences are of a genetic or environmental nature. Here we show remarkably stable and life-long positive associations between BW and cortical surface area and volume across and within developmental, aging and lifespan longitudinal samples (N = 5794, 4-82 years of age, w/ 386 monozygotic twins, followed for up to 8.3 years w/12,088 brain MRIs). In contrast, no consistent effect of BW on brain changes was observed. Partly environmental effects were indicated by analysis of twin BW discordance. In conclusion, the influence of prenatal growth on cortical topography is stable and reliable through the lifespan. This early life factor appears to influence the brain by association of brain reserve, rather than brain maintenance. Thus, fetal influences appear omnipresent in the spacetime of the human brain throughout the human lifespan. Optimizing fetal growth may increase brain reserve for life, also in aging.
Cancers adapt to their mutational load by buffering protein misfolding stress
Authors: Tilk Susanne , Frydman Judith , Curtis Christina , Petrov Dmitri
Published: May 2023

In asexual populations that don’t undergo recombination, such as cancer, deleterious mutations are expected to accrue readily due to genome-wide linkage between mutations. Despite this mutational load of often thousands of deleterious mutations, many tumors thrive. How tumors survive the damaging consequences of this mutational load is not well understood. Here, we investigate the functional consequences of mutational load in 10,295 human tumors by quantifying their phenotypic response through changes in gene expression. Using a generalized linear mixed model (GLMM), we find that high mutational load tumors up-regulate proteostasis machinery related to the mitigation and prevention of protein misfolding. We replicate these expression responses in cancer cell lines and show that the viability in high mutational load cancer cells is strongly dependent on complexes that degrade and refold proteins. This indicates that upregulation of proteostasis machinery is causally important for high mutational burden tumors and uncovers new therapeutic vulnerabilities.Cancers can successfully survive an accumulation of thousands of protein-damaging mutations. Here, we show that high mutational load tumors mitigate these damaging consequences by up-regulating complexes that buffer against protein misfolding stress – providing novel therapeutic vulnerabilities and suggesting that disruption of proteostasis is a hallmark of somatic evolution.
A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells
Authors: Ahmed-Seghir Sana , Jalan Manisha , Grimsley Helen E. , Sharma Aman , Twayana Shyam , Kosiyatrakul Settapong T , Thompson Christopher , Schildkraut Carl L. , Powell Simon N.
Published: May 2023

When replication forks encounter DNA lesions that cause polymerase stalling a checkpoint pathway is activated. The ATR-dependent intra-S checkpoint pathway mediates detection and processing of sites of replication fork stalling to maintain genomic integrity. Several factors involved in the global checkpoint pathway have been identified, but the response to a single replication fork barrier (RFB) is poorly understood. We utilized the
E.coli
-based Tus-
Ter
system in human MCF7 cells and showed that the Tus protein binding to
TerB
sequences creates an efficient site-specific RFB. The single fork RFB was sufficient to activate a local, but not global, ATR-dependent checkpoint response that leads to phosphorylation and accumulation of DNA damage sensor protein γH2AX, confined locally to within a kilobase of the site of stalling. These data support a model of local management of fork stalling, which allows global replication at sites other than the RFB to continue to progress without delay.
High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen
Authors: Yang Wan-ping , Li Mei-qi , Ding Jie , Li Jia-yan , Wu Gang , Liu Bao , Gao Yu-qi , Wang Guo-hua , Luo Qian-qian
Published: May 2023

High-altitude polycythemia (HAPC) occurs in high-altitude (HA) environments and involves an imbalance between erythropoiesis and eryptosis. Spleen/splenic macrophages are an important primary tissue/cell of eryptosis and iron recycling. However, the role of the spleen in the pathogenesis of HAPC and the effect of hypobaric hypoxia (HH) on the biology of the spleen and splenic macrophages are still unclear. We used a mouse hypobaric hypoxia (HH) exposure model to simulate an
in vivo
study of 6000 m HA exposure. For
in vitro
studies, we used a primary splenic macrophage model treated with 1% hypoxia. We found that the HH-treated mouse model promoted erythropoiesis and led to erythrocytosis. In addition, HH exposure resulted in marked splenic contraction followed by splenomegaly for up to 14 days. HH exposure impaired the red blood cell (RBC) handling capacity of the spleen, which was caused by a decrease in splenic macrophages in the red pulp. Moreover, HH treatment for 7 and 14 days promoted iron mobilization and ferroptosis in the spleen, as reflected by the expression of metabolism-related proteins and ferroptosis-related proteins. All of the protein expression levels were similar to the gene expression levels in human peripheral blood mononuclear cells. Single-cell sequencing of the spleen further demonstrated a significant decrease in macrophages in the spleen 7 days after HH exposure. In
in vitro
studies, we confirmed that primary splenic macrophages decreased and induced ferroptosis following hypoxic treatment, which was reversed by pre-treatment with the ferroptosis inhibitor ferrostatin-1. Taken together, HH exposure induces splenic ferroptosis, especially in red pulp macrophages, which further inhibits the clearance of RBCs from the spleen. As such, it promotes the retention of RBCs in the spleen and causes splenomegaly, which may further lead to the persistent production of RBCs and ultimately to the development of HAPC.
Zebrafish Rif1 impacts zygotic genome activation, replication timing, and sex determination
Authors: Masser Emily A. , Noble Tyler D. , Siefert Joseph C. , Goins Duane , Sansam Courtney G. , Sansam Christopher L.
Published: May 2023

Deregulated DNA replication causes human developmental disorders and cancer, but we know little about how DNA replication is coordinated with changes in transcription and chromatin structure. The initiation of replication forks follows a spatiotemporal pattern called the replication timing program. We have developed the zebrafish into a model system to study the mechanisms by which the replication timing program changes during the extensive changes in the cell cycle, transcription, chromatin organization, and nuclear structure that occur during development. Our previous studies identified changes in DNA replication timing patterns occurring from the onset of zygotic transcription through gastrulation in zebrafish embryos. Rif1 is required for DNA replication timing in a wide range of eukaryotes. The broader role of Rif1 in establishing the replication timing program and chromatin structure during early vertebrate development remains unknown. We have generated Rif1 mutant zebrafish and have performed RNA sequencing and whole-genome replication timing analyses on multiple developmental stages. Rif1 mutants were viable but had a defect in female sex determination. Surprisingly, Rif1 loss predominantly affected DNA replication timing after gastrulation, while its impacts on transcription were more substantial during zygotic genome activation. Our results indicate that Rif1 has distinct roles in DNA replication and transcription control that manifest at different stages of development.
Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy
Authors: Liffner Benjamin , Cepeda Diaz Ana Karla , Blauwkamp James , Anaguano David , Frölich Sonja , Muralidharan Vasant , Wilson Danny W. , Dvorin Jeffrey , Absalon Sabrina
Published: May 2023

Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell biology, but study of these organisms using light microscopy is often hindered by their small size. Ultrastructural expansion microscopy (U-ExM) is a microscopy preparation method that physically expands the sample ∼4.5x. Here, we apply U-ExM to the human malaria parasite Plasmodium falciparum during the asexual blood stage of its lifecycle to understand how this parasite is organized in three-dimensions. Using a combination of dye-conjugated reagents and immunostaining, we have catalogued 13 different P. falciparum structures or organelles across the intraerythrocytic development of this parasite and made multiple observations about fundamental parasite cell biology. We describe that the microtubule organizing center (MTOC) and its associated proteins anchor the nucleus to the parasite plasma membrane during mitosis. Furthermore, the rhoptries, Golgi, basal complex, and inner membrane complex, which form around this anchoring site while nuclei are still dividing, are concurrently segregated and maintain an association to the MTOC until the start of segmentation. We also show that the mitochondrion and apicoplast undergo sequential fission events while maintaining an MTOC association during cytokinesis. Collectively, this study represents the most detailed ultrastructural analysis of P. falciparum during its intraerythrocytic development to date, and sheds light on multiple poorly understood aspects of its organelle biogenesis and fundamental cell biology.
aspiración y la pérdida de /s/ en el español de Chile como ejemplo de opacidad
Authors: Bro´s Karolina
Published: May 2023

En este artículo se estudia la llamada aspiración de /s/ implosiva y su pérdida en una variedad del español contemporáneo encontrada en Chile. El concepto de debilitamiento del fonema /s/ se presentará en términos generales, seguido por la presentación del problema dentro de los principales marcos teóricos desde los años 90 del siglo XX hasta hoy en día. El análisis demostrará que una combinación de conceptos propuestos por fonólogos léxicos y de la teoría de la marcación de rasgos fonológicos es el camino correcto hacia la resolución del problema de la opacidad de los procesos fonológicos experimentados en el español de Chile, la derivación siendo el término clave en el reanálisis del chileno dentro del marco de la Teoría Derivacional de la Optimidad.
Descripción funcional de introducciones de tesis doctorales en las disciplinas de química y lingüística
Authors: Jara Solar Iván
Published: May 2023

El presente artículo busca describir, mediante los lineamientos del análisis de género, las introducciones de 34 tesis doctorales correspondientes a las disciplinas de química y lingüística presentadas en el período académico 2003-2007 en la Universidad Católica de Valparaíso de Chile. De acuerdo a este análisis, y a partir de la configuración de una propuesta modélica para introducciones de tesis doctorales, el propósito comunicativo de la introducción en una tesis doctoral es justificar la investigación. Destaca la realización de “pasos retóricos” no descritos en la literatura, como definiciones, procedimiento o impacto, así como la ocurrencia optativa de otros como preguntas, procedimiento u originalidad. Otro hallazgo relevante del estudio en la configuración retórica de la introducción es la distinción de dos audiencias, que se han denominado audiencia primaria y audiencia secundaria, referidas a dos diferentes niveles de lectores objetivo.
Las bases materiales de la desigualdad Caracterización socio-espacial de las redes de servicios urbanos básicos en la ZMVM
Authors:   Urbanista, Maestra y Dra. en Urbanismo por la Universidad Nacional Autónoma de México (UNAM), Caracheo Miguel Celia Elizabeth , Flores Peña Sergio Armando ,   Programa de doctorado en Urbanismo de la UNAM
Published: May 2023

El punto de partida de este trabajo es la noción de que la vida en las ciudades es en esencia una condición socio-técnica, entendida como la forma en que los elementos tecnológicos condicionan la vida humana. Planteamos que las redes de servicios públicos particularmente de agua potable y saneamiento son el soporte fundamental de las actividades urbanas y que de ellos dependen, en buena medida, el vigor de los intercambios, flujos e interacciones de todos los órdenes, que distinguen, en intensidad y sentido, la vida urbana en diferentes lugares. El objetivo por tanto es, identificar los arreglos institucionales que se gestan en la Zona Metropolitana del Valle de México (ZMVM) para mejorar la cobertura de los servicios urbanos básicos y qué relación tienen con la satisfacción de los usuarios. Se revelan diferencias sustanciales de cobertura y calidad, entre la Ciudad de México, el Estado de México e Hidalgo, que dan cuenta de la poca efectividad de la supuesta administración metropolitana. Se plantea como indispensable modificar la arquitectura institucional de los entes locales como condición básica para propiciar una mejor prestación de los servicios, y modificar los mecanismos de coordinación en el ámbito metropolitano.
Management and leadership: relevant notes on Bernardinho’s work and actions
Authors: De Oliveira Aurélio Luiz , Pilatti Luiz Alberto
Published: May 2023

The present study aims to identify the updates and new elements incorporated by Bernardo Rocha de Rezende, known as “Bernardinho”, in the model proposed in the book Transformando Suor em Ouro (Turning Sweat Into Gold). This is a documental, qualitative and exploratory study. The research corpus consisted of eight lectures. The lectures were transcribed in full for analysis. In order to organize and analyze the data, the technique of content analysis was applied, using the software Nvivo Pro 12. It was found that the most emphasized themes in the lectures were: team, focus, leadership, extreme training, discipline and success and its traps. New themes, also widely used, were incorporated: organizational culture, training methodology and hard and soft skills. It is concluded that Bernardinho's main (updated) teachings for leaders to have a winning team are: choosing the right people to work with, always putting the team first, focusing on what is important, imposing extreme work and demanding discipline.
A importância do marketing de relacionamento em uma empresa no setor de saúde e estética da cidade de Manaus
Authors: Ladislau Alice da Silva , Silva Victor Fabian Pinheiro , Machado Victor Hugo Sampaio , Roberto José Carlos Alves , Lira Junior José Roberto
Published: May 2023

O marketing de relacionamento é uma estratégia que pode ser utilizada para captação e fidelização de clientes, como também para melhor na comunicação organizacional. Por isso, a implementação dessa ferramenta pode proporcionar melhora do desempenho interno da equipe, como também uma estratégia eficaz para disseminação da marca. Diante disso, o presente estudo tem como pergunta problema a busca por saber qual as vantagens da utilização do marketing de relacionamento em uma empresa do setor de saúde e estética? O objetivo geral do trabalho é desenvolver uma estratégia de melhoria do relacionamento interno em uma empresa do setor privado saúde e estética da cidade de Manaus. Esta pesquisa é definida quanto aos meios, como pesquisa que busca estudar um caso especifico, pois buscou analisar de forma isolada a problemática em uma empresa de forma individual e sistemática.  O resultado obtido na empresa foi possível avaliar e identificar que as problemáticas encontradas na organização poderiam ser facilmente resolvidas com a implementação das estratégias do marketing de relacionamento. Além disso, o alcance desse resultado foi possível com a utilização dos objetivos específicos traçados.
Study on the Impact of the Nationwide Rural Road Connectivity Programme in India (PMGSY) on the Socio-Economic Status of the Rural People under Wozhuro Rural Development Block, Wokha District, Nagaland, India
Authors: Khuvung Z. , Odyuo Mary N.
Published: May 2023

Rural road connectivity plays a significant role in the socio-economic growth and development of rural people by providing them access to basic amenities for a better livelihood. A study was conducted under the Wozhuro R.D. Block in Wokha district to find out the socio-economic impact of PMGSY road connectivity on rural livelihoods. A purposive random sampling design was used for the selection of respondents. A total of 100 respondents from three villages comprised the sample for the study. A structured interview schedule was developed, and data was collected through the personal interview technique. Statistical tools such as frequency, percentage, and the correlation coefficient were used for analysing the data obtained. The findings showed that rural roads had a great impact on both farm and non-farm sectors. The dependent variable, income                          generation, was found to have a positive and significant relationship with the independent variables, family size (r=0.20**) and land holding (r=0.27**). Also, farm benefits were found to have a positive and significant relationship with land holding (r=0.39**) and annual income                      (r=0.66**), and non-farm benefits (health r=0.44** and education r=0.70**) with annual income, respectively.
Thermal Indices Requirement of Kharif Groundnut (Arachis hypogaea L.) Varieties under Different Sowing Window in Western Maharashtra, India
Authors: Yadavrao Wankhede Sachin , Bhambhar Kharbade Sattappa , Satish Misal Suraj , Dadaji Jadhav Jaywant , Shaikh Abdul Aziz , Atmaram Sthool Vijay
Published: May 2023

An agro-meteorological investigation was undertaken during the kharif season of 2017 and 2018 at the Department of Agricultural Meteorology Farm, College of Agriculture, Pune, Maharashtra State (India). The experiment was laid out in split plot design with three replications. The treatment comprised of four varieties viz., V1: JL-501, V2: RHRG-6083 (Phule Unnati), V3: TAG-24 and V4: JL-776 (Phule Bharati) and four sowing windows viz., S1: 25rd MW (18th to 24th June), S2: 26th MW (25th June to 01st July), S­3: 27th MW (2nd to 8th July) and S4: 28th MW (09th to 15th July). Results showed that the higher GDD was observed in 26th MW sowing window with variety JL-776 (1826 and 1723) and RHRG-6083 (1763 and 1690) followed by variety JL-501 and TAG-24, whereas, higher heat use efficiency (0.088 and 0.100 g/GDD) at peg formation to rapid kernel growth stage was observed under 26th MW sowing window (S2) with variety JL-776 (V2) during 2017 and 2018, respectively. The highest HTU was observed in 26th MW sowing window in variety JL-776 (8254 and 6924) and RHRG-6083 (8171 and 7074) followed by variety JL-501 and TAG-24, whereas, higher heliothermal use efficiency (0.0200 and 0.0309 g/HTU) at peg formation to rapid kernel growth stage was observed under 26th MW sowing window (S2) in variety JL-776 (V2) during 2017 and 2018, respectively. Higher PTU (4818.42 and 4890.75) was observed under 26th MW sowing window (S2) in variety JL-776 (V2) this was followed by var. RHRG-6083, JL-501 and TAG-24 whereas, higher photothermal use efficiency (0.0284 and 0.293 g/PTU) at physiological maturity was observed under 26th MW sowing window (S2) with variety JL-776 (V2) followed by variety RHRG-6083, JL-501 and TAG-24 during 2017 and 2018, respectively.
A Review on Mitigation of Greenhouse Gases by Agronomic Practices towards Sustainable Agriculture
Authors: Devi Okram Ricky , Laishram Bibek , Singh Shobhana , Paul Akash , Sarma Hridesh Harsha , Bora Sarat Sekhar , Devi Sorokhaibam Bijayalakshmi
Published: May 2023

Agriculture is one among the sources of greenhouse gas emission in the World. Agriculture, being a prominent source of economic sectors in developing countries its impact on environmental climate changes both directly and indirectly through emission of greenhouse gases.  To achieve reduced GHGs emissions in agriculture sector, there is a need to adopt climate smart activities and improved food and nutritional security to ensure a climate-smart sustainable agriculture. This short article explores the key ways to mitigate green house gases emissions in agriculture and critically highlights the potential for bacterial nitrogen fixation in soybean which is a recent approach. Symbiotic nitrogen fixation shows a great potential for GHGs mitigation while supporting the agriculture simultaneously. Other agronomic practices include tillage, residue management, rice field management, climate smart agriculture, organic farming and bio energy etc. This will help the farmers and other stakeholders to bring an environmentally friendly agriculture towards more ecological farming approach for future sustainability.
Effect of Phosphorus and Potassium on Growth and Yield of lentil (Lens culinaris L.)
Authors: Sahithi Narisetty , Singh Rajesh , Indu Thakur , Dakshayani Devalla
Published: May 2023

The field experiment was conducted during Rabi season 2022 at experimental field of Crop Research Farm, Department of Agronomy, Naini Agricultural Institute, Sam Higginbottom University of Agriculture, Technology and Sciences, Prayagraj, Uttar Pradesh, India. The soil of experimental plot was sandy loam in texture, nearly neutral in soil reaction (pH7.3), low in organic carbon (0.36%), available nitrogen (171.57 kg/ha), available phosphorus (15.4 kg/ha) and available potassium (232.7 kg/ha). The research consists 3 levels of Phosphorus 30, 40, 50 kg/ha and Potassium 15, 20, 25 kg/ha. The experiment was layout in Randomized Block Design with 9 treatments each replicated thrice. Significantly higher plant height (25.20 cm), plant dry weight (10.34 g), and the yield attributes namely seeds/pod (2.27), pods/plant (91.90), seed yield (1847.93 kg/ha) and stover yield (2948.20 kg/ha) was with the treatment 9 [Phosphorus 50 kg/ha + Potassium 25 kg/ha].
Solvent free Synthesis of 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl] Acetohydrazide Derivatives as Novel Antimicrobial and Antitumor Agents
Authors: Paveendra J. , Vagdevi H. M. , Thippeswamy Dyamanna , Nayaka Yanjerappa Arthobha
Published: May 2023

In pursuit of designing novel chemical entities with antitumor and antimicrobial activities, 2-[(5-methyl-1,3-benzoxazol-2-yl)sulfanyl]acetohydrazidederivatives have been synthesized as a scaffold of a series of amine derivatives, these analogs were on reductive amination with solvent free condition. All the synthesized compounds were assessed for antibacterial, antifungal, and antitumor activities against standard strains. The compounds 3a, 3b and 3g showed highest degree of inhibition against A. flavus and compounds 3a, 3b, 3d and 3h Showed highest degree of inhibition against C. albicans, compounds 3a,3e and 3g has shown the encouraging antibacterial activityresults against E. coli and compounds 3a, 3b and 3h exhibited a promising activity against  B. subtilis. Compounds 3a, 3b and 3c exhibited promising antitumor activity.
Prevalence of Candida Species Isolated from Immuno-Compromised Patients
Authors: Kaur Sunpreet , Rajput Madhurendra Singh , Dhami Balveer Singh
Published: May 2023

Background: Resistance to fungal infections is increasing worldwide, which is highly relevant in immunosuppressed individuals. Candida fungi infection constitutes one of the most common causes of fungal infections in such patients, and it can lead to complications and death. The current study sought to examine the prevalence and species diversity of Candida in samples received by the Microbiology Laboratory over a two-year period.

Methods: The study involved 674 immunocompromised patients. Candida was isolated from clinical samples using wet mount, gram stain, and SDA culture. To further identify the organisms, several tests were conducted, including the germ tube test, cornmeal agar morphology, sugar assimilation, fermentation tests, and BACT/ALERT 3D.

Results: Candida species were found to be present in 6.5% of the population. Candida tropicalis was found to be the most common isolate 20 (45.45%), followed by Candida albicans 9 (20.45%), Candida glabrata 7 (15.9%), Candida parapsilosis 4 (9.09%), and Candida krusei 4 (9.09%). Diabetes, leukaemia, chronic kidney disease, and AIDS were the most common predisposing factors for candidiasis.

Conclusion: Men had a relatively high candidemia prevalence of 68.18%. Uncontrolled diabetes mellitus (DM) and chronic kidney disease (CKD) have been found to be the most common co-morbidities with candidemia in people aged 51 to 70.
Prediabetes and Fracture Risk Among Midlife Women in the Study of Women’s Health Across the Nation
Authors: Shieh Albert , Greendale Gail A. , Cauley Jane A. , Karvonen-Gutierrez Carrie A. , Karlamangla Arun S.
Published: May 2023

Importance

Whether prediabetes is associated with fracture is uncertain.

Objective

To evaluate whether prediabetes before the menopause transition (MT) is associated with incident fracture during and after the MT.

Design, Setting, and Participants

This cohort study used data collected between January 6, 1996, and February 28, 2018, in the Study of Women’s Health Across the Nation cohort study, an ongoing, US-based, multicenter, longitudinal study of the MT in diverse ambulatory women. The study included 1690 midlife women in premenopause or early perimenopause at study inception (who have since transitioned to postmenopause) who did not have type 2 diabetes before the MT and who did not take bone-beneficial medications before the MT. Start of the MT was defined as the first visit in late perimenopause (or first postmenopausal visit if participants transitioned directly from premenopause or early perimenopause to postmenopause). Mean (SD) follow-up was 12 (6) years. Statistical analysis was conducted from January to May 2022.

Exposure

Proportion of visits before the MT that women had prediabetes (fasting glucose, 100-125 mg/dL [to convert to millimoles per liter, multiply by 0.0555]), with values ranging from 0 (prediabetes at no visits) to 1 (prediabetes at all visits).

Main Outcomes and Measures

Time to first fracture after the start of the MT, with censoring at first diagnosis of type 2 diabetes, initiation of bone-beneficial medication, or last follow-up. Cox proportional hazards regression was used to examine the association (before and after adjustment for bone mineral density) of prediabetes before the MT with fracture during the MT and after menopause.

Results

This analysis included 1690 women (mean [SD] age, 49.7 [3.1] years; 437 Black women [25.9%], 197 Chinese women [11.7%], 215 Japanese women [12.7%], and 841 White women [49.8%]; mean [SD] body mass index [BMI] at the start of the MT, 27.6 [6.6]). A total of 225 women (13.3%) had prediabetes at 1 or more study visits before the MT, and 1465 women (86.7%) did not have prediabetes before the MT. Of the 225 women with prediabetes, 25 (11.1%) sustained a fracture, while 111 of the 1465 women without prediabetes (7.6%) sustained a fracture. After adjustment for age, BMI, and cigarette use at the start of the MT; fracture before the MT; use of bone-detrimental medications; race and ethnicity; and study site, prediabetes before the MT was associated with more subsequent fractures (hazard ratio for fracture with prediabetes at all vs no pre-MT visits, 2.20 [95% CI, 1.11-4.37]; P = .02). This association was essentially unchanged after controlling for BMD at the start of the MT.

Conclusions and Relevance

This cohort study of midlife women suggests that prediabetes was associated with risk of fracture. Future research should determine whether treating prediabetes reduces fracture risk.
High‐Throughput Bioprinting of Geometrically‐Controlled Pre‐Vascularized Injectable Microgels for Accelerated Tissue Regeneration
Authors: Franca Cristiane M. , Athirasala Avathamsa , Subbiah Ramesh , Tahayeri Anthony , Selvakumar Prakash , Mansoorifar Amin , Horsophonphong Sivaporn , Sercia Ashley , Nih Lina , Bertassoni Luiz E.
Published: May 2023

Successful integration of cell‐laden tissue constructs with host vasculature depends on the presence of functional capillaries to provide oxygen and nutrients to the embedded cells. However, diffusion limitations of cell‐laden biomaterials challenge regeneration of large tissue defects that require bulk‐delivery of hydrogels and cells. Herein, a strategy to bioprint geometrically controlled, endothelial and stem‐cell laden microgels in high‐throughput is introduced, allowing these cells to form mature and functional pericyte‐supported vascular capillaries in vitro, and then injecting these pre‐vascularized constructs minimally invasively in‐vivo. It is demonstrated that this approach offers both desired scalability for translational applications as well as unprecedented levels of control over multiple microgel parameters to design spatially‐tailored microenvironments for better scaffold functionality and vasculature formation. As a proof‐of‐concept, the regenerative capacity of the bioprinted pre‐vascularized microgels is compared with that of cell‐laden monolithic hydrogels of the same cellular and matrix composition in hard‐to‐heal defects in vivo. The results demonstrate that the bioprinted microgels have faster and higher connective tissue formation, more vessels per area, and widespread presence of functional chimeric (human and murine) vascular capillaries across regenerated sites. The proposed strategy, therefore, addresses a significant issue in regenerative medicine, demonstrating a superior potential to facilitate translational regenerative efforts.
Engineering of Defective MOF‐801 Nanostructures within Macroporous Spheres for Highly Efficient and Stable Water Harvesting
Authors: Yang Chuanruo , Wu Hao , Yun Jimmy , Jin Junsu , Meng Hong , Caro Jürgen , Mi Jianguo
Published: May 2023

Water harvesting using the metal‐organic framework (MOF)‐801 is restricted by limited working capacity, powder structuring, and finite stability. To overcome these issues, MOF‐801 is crystallized on the surface of macroporous poly(N‐isopropylacrylamide‐glycidyl methacrylate) spheres, called P(NIPAM‐GMA), through an in situ confined growth strategy, forming spherical MOF‐801@P(NIPAM‐GMA) composite with temperature‐responsive function. By lowering the nucleation energy barrier, the average size of the MOF‐801 crystals decreases by 20 times. Thus, abundant defects as adsorption sites for water can be installed in the crystals lattices. As a consequence, the composite provides an unprecedented high water harvesting efficiency. The composite is produced in the kilogram‐scale and can capture 1.60 kg H2O/kg composite/day from 20% relative humidity between 25 and 85 °C. This study provides an effective methodology for improving the adsorption capacity through controlled defects formation as adsorption sites and to improve the kinetics through the design of a composite with macroporous transport channel network.