bluuebunny/crossref_metadata_2025 huggingface dataset:
An Open Comparative Randomized Study of the Effectiveness and Safety of Risperidone and Sodium Valproate for Secondary Prevention of Relapses of Bipolar Disorder I for 24 Months
Authors: Kostyukova E. G. , Ryvkin P. V. , Alfimov P. V. , Shafarenko A. A. , Andreychik L. A. , Burygina L. A. , Mosolov S. N.
Published: January 2023

Background: Comparative studies of monotherapy with second-generation antipsychotics (SGA) or mood stabilizers in the prevention therapy of Bipolar Disorder (BD) relapses, including those with psychotic symptoms, have not been conducted. Objective: a comparative study of the clinical features of risperidone (RIS) and sodium valproate (SV) in the prevention of relapses of BD. Patients and methods: 96 patients with BD-I (F31, ICD-10) were included, the duration of the disease was at least 2 years, the presence of at least two affective episodes (including psychotic symptoms). Design — open comparative randomized study. Study duration was 24 months. Patients were sequentially divided into groups of RIS and SV, comparable in the number of patients, clinical and sociodemographic indicators. The effectiveness of therapy was determined by comparing the indicators of the dynamics of the course of the disease for 2 years preceding the start of therapy (control period) and 2 years after the treatment beginning. Results: 14 patients dropped out in the first month after the start of therapy due to adverse events, 82 completed the study. The total duration of episodes decreased by 40-60%, the frequency — by 37.2% — 43.3% (p ≤ 0.05). The proportion of responders in the RIS group was 78.1%, SV — 68.3%. Complete suppression of phase formation was observed in 43.75% in the RIS group, in 10.7% — in the SV group. In the RIS group, the total duration of depressive episodes decreased by 38.3% (NS), manic by 65.2% (p ≤ 0.001), in the SV group — by 31.9% (NS) and by 52.9% (p ≤ 0.05), respectively. As to BD with psychotic symptoms, 85% of respondents were in the RIS group, and 50% were in the SV group. The average number of adverse events per patient in the group of SV was 0.9, RIS — 2.1. Conclusions: SV and RIS are comparable in effectiveness with better tolerance of SV. In patients with psychotic symptoms, the effectiveness of RIS was higher than that of SV.
Association of Non-Suicidal Self-Harm with Anxiety, Depression and Aggressive Behavior in Young Men of Military Age
Authors: Evseev V. D. , Bokhan N. A. , Mandel A. I. , Kadochnikova S. V.
Published: January 2023

Background: suicidal behavior, intentional self-harm and non-suicidal self-harm are important precursors of suicide in children and adolescents. The objective: to determine the prevalence and structure of non-suicidal self-harm, as well as the relationship of non-suicidal self-harming behavior with aggression, anxiety and depression in a non-clinical group of young men of military age. Participants and methods: the object of the study was 507 young men (from 18 to 27 years old). The average age of the examined was 19.32 years (± 2.35). Assessment of non-suicidal self-harm was carried out using a clinical interview and the scale of self-harming behavior (Polskaya N.A., 2014). The analysis of patterns of aggressive behavior was carried out with the Buss-Perry Aggression Questionnaire (BPAQ) to identify the propensity to aggression, the assessment of anxiety and depression level was assessed on Beck Anxiety and Depression Scales (BAI; BDI). Results: the study showed a high prevalence of non-suicidal selfharm in the non-clinical population of young people (33.9%). Instrumental self-harm was committed at least once in a lifetime by 14.7% of the surveyed, somatic — 19.2%. The most common acts of instrumental self-harm are blows with a fist, foot, head or body body on hard surfaces and cuts with cutting objects. From somatic — biting nails and lips, biting cheeks and tongue, combing the skin and creating obstacles to wound healing were the most frequent. As a result of the correlation analysis of the links of acts of self-harm with the domains of the scale of propensity to aggression from instrumental self-harm, a significant positive correlation was found in relation to self-burns. Punching your body and pulling out your hair turned out to be associated with all domains of the aggression scale. Self-harming was accompanied by depressive symptoms. Symptoms of anxiety correlate with somatic self-harm — punching your body, scratching your skin and biting your cheeks or tongue. Conclusion: non-suicidal self-harm showed positive correlations with manifestations of aggression, anxiety and depression. Effective and evidence-based prevention programs can be implemented at the population, subpopulation and individual levels to timely identify self-harming behavior. At the stage of psychiatric examination of young people, it is advisable to include in the complex of psychodiagnostic methods scales aimed at identifying self-harm, anxiety, depression and aggressive behavior.
Treatment of Acute Drug-Induced Psychoses, Associated with Modern Synthetic Psychoactive Substances
Authors: Bokhan N. A. , Usov G. M. , Rakitin S. A. , Kurushkin M. V.
Published: January 2023

Use of new synthetic drugs (synthetic cannabinoids — “spices”, synthetic psychostimulants — “salts”, synthetic GABA-agonists — “butyrates”) is associated with a high risk of psychoses. Nowadays there are no evidence-based guidelines for treatment of these psychotic disorders. Objective: to develop effective therapeutic strategies for the treatment of acute substance-induced psychoses associated with modern synthetic drugs. Material and methods: 96 patients with substance-induced psychoses associated with synthetic cannabinoids (n = 32), synthetic psychostimulants (n = 33), and synthetic GABA-agonists (n = 31) were examined. In these groups we estimated effectiveness of different combination therapy: desintoxication and benzodiazepine, desintoxication and benzodiazepine and haloperidol, desintoxication, benzodiazepine and phenibut. The following methods were used: clinical-psychopathological, laboratory, statistics. Results: сomparative efficacy of therapeutic strategies differed in three investigated groups. In psychoses associated with synthetic cannabinoids the most effective strategy was haloperidol add-on. Differences between treatment approaches in group of psychostimulants-induced psychoses were not found. In psychoses associated with synthetic GABA-agonists the most effective strategy was phenibut add-on. Conclusion: the choice of effective therapeutic intervention in drug-induced psychosis should be based on type of synthetic drug.
Тhe clinical case of benign monomelic amyotrophy of the lower limb
Authors: Andreev R. V. , Smolyannikova A. V. , Golokhvastov S. Yu. , Emelin A. Yu. , Lobzin V. Yu. , Litvinenko I. V. , Tsygan N. V. , Frunza D. N. , Markova M. N. , Lupina N. A.
Published: January 2023

The benign monomelic amyotrophy of the lower limb is a slowly progressive disease that is clinically manifested by muscle atrophy in only one lower limb. This disease is quite rare, while it is most common in Asian countries (about 80 cases have been described). According to the literature a total of 16 cases of benign monomelic amyotrophy of the lower limb were described in Europe by 2000. Etiology and pathogenesis have not been reliably studied now. The article presents a clinical case of the development of this disease in a 42-year-old patient. The patient was admitted with complaints of weakness in the right leg and its decrease in volume. During the period of hospitalization, diff erential diagnosis was carried out with amyotrophic lateral sclerosis, progressive muscle atrophy, Hirayama disease, vascular and paraneoplastic processes. According to the results of a comprehensive laboratory and instrumental examination, the diagnosis was fi rst established: benign monomelic amyotrophy of the lower limb. The father of a patient who had atrophy of the muscles of the left lower limb would also be examined. According to the data of hereditary anamnesis, an assumption was made about the presence of the phenomenon of anticipation in the inheritance of benign monomelic amyotrophy of the lower limb. This article describes for the fi rst time a case of benign monomelic amyotrophy of the lower limb in the domestic literature, as well as a familial case of this disease all over the world.
KEARIFAN LOKAL BUDAYA SUKU SAKAI TERHADAP SUMBER DAYA PERAIRAN DI KABUPATEN BENGKALIS
Authors: Putra Setia , Effendi Erdianto
Published: January 2023

AbstrakMasyarakat Suku Sakai menangkap ikan di sungai dengan menombak dan mengail, serta menangkap udang dengan menggunakan tangguk. Di rawa-rawa atau di sungai-sungai kecil mereka menangkap ikan dengan menggunakan lukah dan jaring.  Mereka memasang lukah dari jaring pada sore hari menjelang malam dan pada pagi hari dapat dilihat hasil tangkapannya. Ada larangan menangkap ikan dengan putas,  pukat, sentrum dan racun bisa didenda adat berupa uang adat yang disepakati Pengurus Bathin (Kepala, Manti, Mangku). Dilarang menebang hutan dekat sungai dan danau, bila dilakukan maka didenda adat untuk memulihkan kerusakan dan disuruh menanam pohon 7 kali lebih banyak.Kata Kunci: kearifan lokal, perairan, Sakai AbstractThe Sakai tribe catches fish in the river by using the spear and hook, and using tangguk for shrimp. In swamps or small rivers they used a fish trap and netting to catch the fish. They put on the fish trap nets on the afternoon or before the night and they take the catch out in the morning. There is a ban on fishing with putas, gillnets, centrum and toxins and it can be fined by indigenous customary pecuniary who agreed by Bathin Board (Chief, Manti, Mangku). It is forbidden to cut down the forests near the rivers and the lakes, and the indigenous fined to recover the damage is to plant the tree seven times more.Keywords : local wisdom, water, Sakai
Membangun profil siswa berkebinekaan global melalui ajaran Tamansiswa Ngandel, Kandel, Kendel, dan Bandel
Authors: Jamalulail Qodri , Yuniharto Bonifatius Sigit , Zulfiati Heri Maria
Published: January 2023

Belajar sejarah bagi siswa sekolah Dasar melalui membaca buku merupakan hal yang membosankan. Penelitian ini bertujuan untuk mendeskripsikan penanaman profil siswa berkebinekaan global melalui implementasi ajaran Tamansiswa Ngandel, Kandel, Kendel, dan Bandel. Data penelitian diperoleh melalui kegiatan observasi pembelajaran, wawancara siswa dan dokumentasi hasil pembelajaran. Subjek penelitian merupakan siswa kelas lima SDN Sariharjo tahun pelajaran 2021/2022. Lokasi penelitian adalah monument Jogja Kembali. Implementasi ajaran Tamansiswa ditempuh melalui enam langkah model pembelajaran koorperatif tipe penyelidikan kelompok (GI) yaitu 1) menentukan pembahasan materi pelajaran dan mengelompokkan siswa; 2) menyusun kegiatan belajar; 3) melakukan pengamatan dan usaha memperoleh informasi; 4) menyelesaikan laporan kelompok; 5) memaparkan laporan hasil belajar; dan 6) mengevaluasi pemahaman siswa. Hasil penelitian menunjukkan bahwa siswa senang belajar sejarah melalui kegiatan kunjung museum. Ajaran Tamansiswa ngandel, kandel, kendel, dan bandel nampak saat siswa mengalami secara langsung kegiatan perencanaan, penyelidikan sampai pelaporan hasi penyelidikan. Profil siswa berkebinekaan global nampak melalui siswa dapat menghargai sejarah dan lokasi peninggalan sejarah di dekat sekolah mereka.
Potential Enhancement in The Nutritional Value of Local Agro-Waste Through Cultivation of Pink Oyster Mushroom (Pleurotus djamor)
Authors: Hutabarat Amelia Lulu Rosalin , Lestari Wenni Meika , Kuswoyo Anton , Ali Abdul Muta , Sari I.
Published: January 2023

The present study aimed to examine the effect of locally available agro-industrial wastes on the growth and productivity of pink oyster mushrooms (Pleurotus djamor) and the potential use of substrates as animal feeding based on its compositional change following mushroom growth. A total of three substrate formulations labeled OPF (80% oil palm frond), CS (80% corn straw), and OPFCS (40% oil palm frond + 40% corn straw) were prepared. Aside from the earliest mycelium completion, pinhead formation, and fruiting bodies maturation, CS and OPFCS exhibit the best total yield, dry weight, and biological Efficiency. On the contrary, P. djamor grown in OPF resulted in the minimum in most of the parameters measured. Therefore, CS, single and in combination with OPF could be utilized as an alternative growing media for the cultivation of P. djamor. The analysis of chemical compositions showed that the growth of P. djamor significantly reduced the crude fiber (CF) and increased the crude protein (CP) content of the mycelium-treated substrate. In contrast, THE CP content of the spent is unchanged or relatively lower than that of the initial substrate. It can be concluded that compared to the spent, mycelium-treated substrate had higher values of being used for animal feeding.
La redazione delle Animadversiones nell’esperienza di un Difensore del Vincolo
Authors: Giannelli Vito
Published: January 2023

Dopo alcuni cenni sulle modalità di stesura delle animadversiones, con riferimento anche a fattispecie concrete in riferimento ai singoli capi di nullità, si passano in rassegna i diversi mezzi di prova previsti dalla giurisprudenza rotale. Si affronta anche la stesura delle animadversiones sia nella procedura amministrativa del super rato che in quella in favor fidei.
Students’ Perception of the Implementation on Total Physical Response (TPR) in English Teaching
Authors: Zur Sarjaniah , Selfieni Selfieni
Published: January 2023

This study aims to determine students' perceptions of the application of the total physical response (TPR) method in foreign language lessons in the classroom. The participants of this study focused on students in one of Islamic Junior High School in Poleang. Vocabulary is a major problem for students in learning English. This study uses a qualitative research. The main reason for descriptive research in qualitative research begins with the question 'how' or 'what'. Qualitative research aims to explain the phenomenon profusely through deep data collection. This study offers some important insights into a number of aspects of theoretical and pedagogical benefits. The findings of this study can be used as a reference for those who conduct research on students' perceptions in the application of the total physical response (TPR) method in learning foreign languages in the classroom. The application of the TPR method in learning English in the classroom makes the class more fun, interesting, and provides new experiences for students. While the benefits of applying the TPR method in the classroom learning process include making students easy to understand the material, encouraging student motivation, encouraging student enthusiasm, making students more interested and active in participating in the learning process.
La construcción de ciudadanía mediante el diálogo socrático en espacios interculturales
Authors: Bermeo Vega José Luis
Published: January 2023

En las últimas dos décadas, cada vez más instituciones de educación superior en diversos países han realizado importantes esfuerzos por formar a sus estudiantes en lo que algunos llaman ciudadanía global y otros –dependiendo del enfoque que se dé al concepto–, ciudadanía para el siglo XXI o ciudadanía crítico democrática, que, para efectos de este trabajo, se puede entender como una manera de situarse consciente y autónomamente frente a un mundo cada vez más problemático para incidir en él procurándole una transformación positiva. Las maneras de desarrollar las habilidades del ciudadano global, así como las formas de medirlas, han sido, a su vez, muy diversas. Este ejercicio se propone presentar algunos resultados preliminares de una experiencia formativa iniciada en 2018 en la Universidad Iberoamericana, Ciudad de México, que explora la aplicación del diálogo socrático en espacios interculturales como herramienta para el desarrollo de tres habilidades constitutivas de la ciudadanía global: el pensamiento crítico, la empatía y la solidaridad.
Biostimulatory effect of seaweed extract on the fruiting and runner production of Strawberry
Authors: Rana Vishal Singh , Lingwal Kusum , Sharma Sunny , Rana Neerja , Pawar Ravina , Kumar Vijay , Sharma Umesh
Published: January 2023

The strawberry plant is an herbaceous perennial and having a shallow root system needs effective nutrient management. The conventional farming system involves the enormous use of chemicals which leads to the degradation of plant and soil health. On the contrary, organic fruit production is more beneficial for plant health and organic fruit production has gained momentum due to increasing the cost of fertilizers and growing ecological concerns. Seaweed extracts are considered an organic farm input as they are environment-friendly and safe for human health. Keeping in view the bio-stimulatory potential of seaweed extracts, a study was conducted to elucidate their effect on the blooming, yield, quality, and runners' production of strawberries under polyhouse conditions during the year 2018-19. The seaweed extract (SWE) was used at variable concentrations viz, 0.75 ml L-1, 1.0 ml L-1, and 1.25 ml L-1 which were applied at the pre-flowering stage (PFS) or Fruit set stages (FSS) or both the stages (PSS and FSS). The study revealed that the foliar spray of seaweed extract at pre-flowering and fruit set enhanced the blooming characteristics and runner production. Furthermore, the plant treated with 1.0-1.25 ml L-1 seaweed extract at the pre-flowering and fruit set stage exhibited the highest cumulative yield and better fruit quality characteristics.
Variability, character association and path analysis for Annona yield and quality attributes
Authors: S. Mahla Jagruti , V. Soni Nishit , C. Patel Pranay , V. Patel, Ashita , Dasalania Jay P. , Roul Sarojini
Published: January 2023

The knowledge of genetic variability among the genotypes for yield and quality attributes is the utmost requirement for any crop improvement work. The eighteen Annona genotypes of two species were studied for five leaves and fruit morphological attributes and twenty-nine components related to growth, yield and fruit quality. The experiment was arranged in a randomized block design in two replicates. A vast variability among the genotypes was revealed as seen based on the significant difference from ANOVA for all the quantitative traits. For morphological traits, genotypes showed variations for leaf shape, base and apex also for fruit shape and segmentation. The high magnitude of heritability and genetic advance as per cent mean was noted for most of the traits indicated presence of fixable genes and least influence of environment for inheritance. The results of the association analysis presented significant and positive association of fruit yield with growth and fruit morphology and fruit quality attributes at both genotypic and phenotypic levels. A strong influence of fruit traits and fruit quality related traits on yield observed owing to their positive and significant direct effects. The pulp/seed ratio, fruit weight, fruit per plant, total soluble solids, sugar content could be emphasize to discriminate the various Annona genotypes so as to utilize them for future hybridization programme to generate desirable genotypes for yield and quality.
METHODOLOGY FOR REMOTE SENSING MONITORING OF ORGANIC WHEAT CROPS
Authors: Chanev Milen , Filchev Lachezar , Valcheva Darina
Published: January 2023

In the presented methodology for aerospace monitoring of autumn wheat crops, grown under the conditions of organic farming, the ways of applying ground and aerospace methods are discussed in detail. This includes field experiments, phenological observations, GIS and remote sensing methods and data (data from Sentinel-2 satellite and WingtraOne unmanned aerial vehicle with MicaSense RedEdge-MX multispectral camera and RGB camera) and statistical analyses. In order to achieve the aim and objectives of the study, an experiment was conducted on a organically certified production field sown with einkorn (Triticum monococum) in the period 2020-2021. The field is part of the holding of ET "Borislav Slavchev" in the village of Byala Reka, Parvomai Municipality, South-Central Bulgaria on the soil type of leached chernozem clays, with a size of 136 da.
Do Actions Speak Louder than Words? A Foreign Exchange Intervention Analysis
Authors: Pinzón-Puerto Freddy , Villamizar-Villegas Mauricio
Published: January 2023

We revisit an old question but with a new identification strategy, namely the difference in exchange rate effects between announced (“vocal”) and secret (“dirty”) foreign exchange intervention. Using a Regression Discontinuity Design, we exploit a rule-based intervention mechanism enacted by the Central Bank of Colombia that, under observable and deterministic conditions, triggered either the issuance of FX options or the ability to exercise them. We take the former (issuance) as central bank announcements under a sharp setting, since the rule and information that triggered the issuance of options was public, and we take the latter (exercise) as secret trades under a fuzzy setting, since traders could have chosen (but were not required) to exercise their options in the following days after issuance. Our results indicate that, unconditionally, both announcements and secret trades carry similar effects. However, the effects of announcements are considerably amplified conditional on: (i) higher central bank credibility, (ii) less frequent announcements, and (iii) episodes of higher FX volatility.
Doenças raras e o grau de informação da população
Authors: Silveira Pâmela da Silva Campos da , Souza Ana Beatriz Aquino de , Moreira Carla Patrícia de Souza , Viana Neto Amaro
Published: January 2023

Doenças raras são aquelas que ocorrem quando há dano ou alteração no estado de saúde do indivíduo e não acontecem com extrema frequência comparado às doenças consideradas mais comuns. Elas constituem um importante problema de saúde coletiva que não é devidamente reconhecido, o que implica a negligência de informações fundamentais quanto ao nível de conhecimento social que deveriam contribuir para uma gestão de saúde pública significativa. Para tal, a pergunta norteadora deste material foi: Qual é o nível de informação da população brasileira sobre a existência dessas doenças? Assim, o objetivo principal foi conhecer o grau de informação da população acerca das doenças raras. A metodologia adotada foi uma pesquisa aplicada, de abordagem qualitativa e procedimentos técnicos documentais e bibliográficos, com objetivos exploratórios e descritivos. A partir disso, foi definido doenças raras através da literatura científica, elaborou-se um questionário on-line e uma entrevista estruturada aplicados na internet a fim de descobrir o nível de desconhecimento da população brasileira sobre doenças raras e os desafios comuns aos gestores dos 17 estabelecimentos de saúde habilitados como Serviço de Referência em Doenças Raras pelo Ministério da Saúde. Entre os principais resultados e conclusões estão que 58,7% da população é orientada no assunto enquanto 41,3% ainda tange ao desconhecimento, sendo necessário ainda haver campanhas de educação em saúde direcionada ao percentual de público leigo. Além disso, obteve-se a resposta de apenas 1 instituição entre as 17 habilitadas revelando a necessidade dos gestores da saúde em apoiar e implementar ações para identificação precoce desse tipo de enfermidade e que as doenças raras ainda são invisíveis para muitas pessoas. A partir dos resultados obtidos foi produzido um e-book direcionado a população geral com o intuito de disseminar informações importantes sobre a temática.
Assessing the impact of liquidity on the value of assets return
Authors: Khan Muhammad Asim , Hussain Arsalan , Ali Muhammad Muzaffar , Tajummul Mohsin Ali
Published: January 2023

The concept of liquidity has been widely discussed in the literature of financial management to determine its influence on the different aspects of company’s financial performance. In a firm, there is a deficit and surplus in liquidity related to stock and it needs to be monitored to control the equity of a company. Deficit liquidity arises from a shortage in stocks and this can cause the profitability to below and this can cause a cashflow concern for the company. Hence, it is critical to evaluate the impact of liquidity on the returns and value of the study. Therefore, the following research is mainly conducted to investigate the effect of liquidity on the stock return from the context of two markets which are Pakistan and the United Kingdom. The data is gathered from total of 60 companies where the 30 companies belong to Pakistan whereas the remaining 30 companies are from UK. The time frame from which the data is collected is from 2005 till 2019 which makes a total time period of 15 years. With respect to the results of regression of the Pakistani data, it was determined that the illiquidity has significant and negative influence on the stock return whereas interest rate and HML has significant and positive influence on stock return. It is clear that the investors are highly concerned with the liquidity of the Pakistani companies as the increase of liquidity would cause reducing the stock return. While reflecting to the results of regression on UK data, it was identified that illiquidity has insignificant influence whereas the book to market, SMB, HML, IR and LNGDP has significant influence. Book to market and interest rate has negative influence on stock return whereas SMB, HML, interest rate and GDP have positive effect on stock return. Furthermore, recommendation and limitations are also highlighted in the study.
The role of entrepreneurial orientation and social capital toward technology innovation among SMEs in Kurdistan
Authors: Lawa Kheder Omar , E-Vahdati Sahar
Published: January 2023

The emergence of the fourth industrial revolution has made fundamental changes to technology, industries, and societal patterns and processes. SMEs are familiarizing themselves with new technological innovations to adapt to the current shifts. SMEs significantly contribute to economic progress by creating jobs, generating revenue, reducing poverty, and launching new ventures, especially in developing economies. However, the contribution of the SMEs in Kurdistan is limited due to the weak capacity to produce technological innovations and the inability to execute manufacturing processes effectively. So, the study aims to investigate the impact of Entrepreneurial Orientation (EC) and Social Capital (SO) on the Technological Innovation (TI) of Kurdistan SMEs in the Kurdistan region of Iraq. This study used the resource-based theory as the underlying theory for its presumptions, and its model was constructed using self-administered questionnaires. Three hundred forty-four business owners participated in this study, yielding a response rate of 68%. The results of the current study showed that social capital and entrepreneurial orientation both significantly and positively affect technological innovation. The study will contribute to technology innovation adoption among small industrial companies in Kurdistan and reduce potential setbacks for technology adoption, highlighting externally generated knowledge of entrepreneurial orientation and social capital.
Exploring audit quality at the Inland Revenue Board Malaysia
Authors: Zainal Zuriahati , Saad Natrah , Zainol Arrifin Zaimah
Published: January 2023

Audit quality at the Inland Revenue Board Malaysia (IRBM) is a crucial element in the audit process to ensure no violation of tax reporting by the taxpayers. Hence, it is important to understand whether tax auditors perceive audit quality equally.  Furthermore, recognizing the level of audit quality is also important to assist the tax authority in strategizing their efforts. This triggers researchers to embark on this exploratory study through document review and interviews. Data gathered were analysed using descriptive and thematic analysis. Results indicate that there is different perception of audit quality among tax officers, namely competency to detect the amount of audit settlement, audit settlement within the time frame and the achievement of the given key performance indicators (KPIs). The findings further indicate that the level of audit quality is quite alarming particularly with reference to the number of aging cases. The findings from this study provide an insight to the IRBM in their effort to streamline the direction of the tax auditors in improving audit quality.
Thermodynamic properties of GaAs quantum dot confined by asymmetric Gaussian potential
Authors: Ghanbari Ahmad , Birooni Raziyeh
Published: January 2023

In the present work, we have calculated the thermodynamic properties of an asymmetrical Gaussian potential quantum dot under external electric field. To this end, we have solved the Schr�dinger equation and have obtained the energy levels and wave functions, analytically. According to the obtained eigenvalues, we have calculated the partition function of the system by the Poisson summation formalism. Afterward, we have deduced some thermodynamic properties such as mean energy, entropy, specific heat and free energy under the application of an external electric field using the canonical ensemble approach. These thermodynamic properties for an asymmetrical Gaussian potential GaAs quantum dot have been discussed in detail.
The E3 ligase TRIM31 regulates hematopoietic stem cell homeostasis and MLL-AF9 leukemia
Authors: Zhang Kai , Liu Dingdong , Li Yafei , Shi Zhencan , Guo Jun , Gao Chengjiang , Wang Hu , Ju Zhenyu , Diao Daojun
Published: January 2023

Hematopoietic stem cells (HSC) are kept in a quiescent state to maintain their self-renewal capacity. Proper regulation of cyclin-dependent kinases (CDK) and cyclin proteins is critical for the maintenance of HSC homeostasis. Here, we found that the E3 ligase, TRIM31, regulates HSC homeostasis and leukemia through the accumulation of CDK8. TRIM31 deficiency promotes hematopoietic stem and progenitor cell proliferation and long-term HSC exhaustion. Serial competitive transplantation assays showed that TRIM31-deficient HSC exhibit impaired reconstitution ability. TRIM31 loss led to a lower rate of survival of mice under conditions of stress (5-fluorouracil administration), which was correlated with a lower number of hematopoietic stem and progenitor cells. In a murine model of acute myeloid leukemia, the initiation of leukemia was significantly accelerated upon TRIM31 deletion. Mechanistically, we found that ubiquitin-mediated degradation of CDK8 was impaired by TRIM31 deletion, which further induced transcriptional expression of PBX1 and cyclin D1. Taken together, these findings reveal the function of TRIM31 in the regulation of HSC homeostasis and leukemia initiation, and indicate the physiological importance of TRIM31 in the early stage of the development of leukemia.
WILL WE BE ABLE TO USE RECYCLED PLASTICS OR SHALL WE DECIDE FOR PACKAGING FREE PRODUKCTION?
Authors: MILICHOVSKÝ FRANTIŠEK , MAJEROVÁ ADÉLA
Published: January 2023

Recycled plastic and its use are imperative for preserving the environment, including proper plastic wash-out. Will we ever be able to push the Czech population and firms to use recycled material? Or is it happening spontaneously? A questionnaire created on Google Forms involves ten legislative and motivational questions comprising relevant data on the amount of plastic in municipal waste between 2010 and 2020 from the Czech Statistical Office. We found that the population understands the importance of using recycled material and recycled plastic without the government's impulse. Despite the high capital intensity, the state should impose taxes to protect the sustainable environment. We suggest a comprehensive and in-depth survey to acquire more accurate data.
Analisis Debit Banjir Rencana Daerah Tangkapan Air Waduk Tugu Menggunakan HEC-HMS
Authors: Rasyid Anas Zulfikar , Suharyanto Suharyanto , Kodoatie Robert Johanes , Satriyawan Yogi Pandhu
Published: January 2023

Over the course construction  of Tugu Reservoir, it is proposed to build a spillway gate to increase its  performance as a flood control infrastructure. The construction planning of spillway gate requires a calculation of design flood discharge for Tugu Reservoir Catchment Area. The latest calculation was carried out during its construction planning in 2010. Therefore, it is necessary to evaluate and recalculate the design flood discharge using the latest data. This study aims to model design flood discharge of Tugu Reservoir Catchment Area using HEC-HMS software. This software is able to simulate rainfall-runoff modeling in a catchment area. Based on field conditions, Tugu Reservoir catchment has parameters, curve number value of 79, impervious value of 5%, and a lag time of 4.81 minutes. The result of the HEC-HMS modeling shows that the design flood discharge of Tugu Reservoir for Q100 is 369,30 m3/s; Q1000 is 656,70 m3/s; and QPMF is 995.30 m3/s. Based on the test using Creager Graph, the design flood discharge for Tugu Reservoir is still in the reasonable category with C value below 100. The result of the HEC-HMS modeling is not much different from the calculation result of Tugu Reservoir Construction Planning in 2010.
Analisis Respon Tekanan Air Pori Terhadap Muka Air Waduk Pada Bendungan Jatibarang
Authors: Setyadi Angga , Suharyanto Suharyanto , Edhisono Sutarto
Published: January 2023

The construction of dams is very important for fulfill water demand and as flood control. In addition to having many benefits, a dam also has a high risk. The stability of the dam is strongly influenced by the magnitude of the pore water pressure. The purpose of the study was to determine the response of pore water pressure to the reservoir water level, as well as to find out the comparison of the results of pore water pressure analysis using plaxis 2D and piezometer instrument readings. The piezometer readings are graphed as a function of the reservoir water level. Based on the graph, it can be seen that the piezometer readings correspond to the fluctuations in the reservoir water level. The piezometer upstream side have a faster response to the reservoir water level, which is between 14 to 41 days. While downstream piezometers have a longer response, which is between 25 to 61 days. Pore ​​water pressure analysis using plaxis 2D at location P.17 (upstream) resulted in a smaller value than piezometer reading. While at location P.18 (downstream) it produces a greater value than the piezometer reading. The relative error value of the two analyses is 7.73% < 12% is still considered good, so the difference is acceptable.
Real-World Experience of Apremilast in Treating Psoriatic Arthritis Patients with Comorbidities
Authors: Chan Antoni , Rigler Kathryn , Herdman Linda
Published: January 2023

This observational study aimed to evaluate the efficacy and real-world experience of apremilast (APR) in treating psoriatic arthritis (PsA) patients with co-existing conditions presenting to clinic. Data from 28 patients treated with APR for PsA were collected between January 2016 and January 2019. Outcome measures disease activity score 44-C-reactive protein (DAS44-CRP), 0–68 for tender and 0–66 for swollen joint count, were collected at Weeks 0, 16, and 52. Response was classified using the Psoriatic Arthritis Response Criteria (PsARC). Adverse events or worsening of pre-existing conditions were recorded. Results included outcomes at Weeks 16 and 52 which showed a percentage reduction in mean DAS44-CRP at Weeks 16 and 52 by -1.4 and -1.9, respectively. There was percentage reduction at Weeks 16 and 52 of tender (-55.5%, -75.4%) and swollen (-45.8%, -61.5%) joint counts from baseline. It was also found that 19/28 (68.0%) patients were responders by PsARC criteria up to Week 52. Responders had shorter disease duration (mean: 4.9 years, standard deviation: 1.9) and lower previous exposure to biologic disease-modifying antirheumatic drugs (bDMARD); 16/19 subjects (84.0%) had no previous bDMARD. There were no serious adverse events during the study and no worsening of co-existing conditions during treatment. In this real-world observational study, APR was shown to be effective in PsA patients with multiple co-existing conditions. APR was more effective in PsA patients with shorter disease duration and in bDMARD naïve patients. APR provides another effective treatment option for PsA patients with multiple co-existing conditions.
Possibilities of aggressive oncosurgery in treatment of IIA–IIIB stages of cervical cancer
Authors: Khakimov G. A. , Tashmetov M. N. , Khakimova G. G. , Musurmonov K. U. , Khakimova S. G.
Published: January 2023

Introduction. Arming gynecological oncology with modern chemotherapy schemes, elements of aggressive oncosurgery, it is possible to achieve an increase in the number of cured patients with locally advanced forms of cervical cancer (CC), providing an improvement in the immediate and long-term results of treatment. The proposed method of surgical treatment is the method of choice for the surgical treatment of patients with locally advanced forms of cervical cancer (stages IIA–IIIB).

Purpose of the study. Introduction into clinical practice of the method of surgical treatment of IIA–IIIB stages of cervical cancer.

Material and methods. Long-term results of treatment of 155 patients with morphologically verified stage IIA–IIIB cervical cancer were studied. The patients underwent neoadjuvant chemotherapy (NACT) (n = 110) and chemoradiotherapy (CRT) (n = 45). When resectability was achieved, the patients underwent surgical treatment using a new technique. Overall survival (OS) and progression-free survival (PFS) outcomes were assessed.

Results. In the period from 2017 to 2020, 155 patients with stage IIA–IIIB cervical cancer after NACT (n = 110) and CRT (n = 45) underwent combinedextended extirpation of the uterus with appendages according to our patented method. The most frequent postoperative complications were urination disorders in 106 (67 [60.9%] and 19 [42.2%]) patients, lymphatic cysts in 30 (20 [18.2%] and 10 [22.2%]) patients and vesicovaginal fistula in 7 patients (5 [4.6%] and 2 [4.4%]), respectively. According to the results of a pathomorphological study, the most frequent tumor response to NACT was III degree of therapeutic pathomorphosis (TP) in 44 (40.0%) patients of group 1 and in 21 patients – IV-degree TP, amounting to 46.6%. The median follow-up was 28.7 (from 3.6 to 51.1) months. During this time, 30 patients died in both groups (17 [15.5%] and 13 [28.9%]) (p = 0.047). Disease progression occurred in 16 (10.3%) patients (6 [5.5%] and 10 [22.2%]) (p = 0.004), respectively. The 3-year OS was 83.8 ± 3.7 and 71.0 ± 6.8 (p = 0.131), PFS – 93.5 ± 2.6 and 77.7 ± 6.6 (p = 0.006).

Conclusions. The proposed method of surgical treatment of IIA–IIIB stages of cervical cancer has a novelty and can be used in practical medicine for the surgical treatment of oncology diseases in cervical cancer
Mortal Complication of Kikuchi–Fujimoto Disease; Lower Gastrointestinal Bleeding, Case Presentation and Literature Review
Authors: Akgol Gur Sultan Tuna , Tahiroğlu Aslı Leyla , Kocak Abdullah Osman
Published: January 2023

In this report, we inform you that a patient with CFD, known as a benign disease, died due to massive lower GI bleeding. Although KFD is a benign disease, we have seen in this case that it can result in death. A 28-year-old Turkish male patient was brought to the hospital with complaints of high fever, fatigue, sweating and difficulty breathing. A cervical examination revealed that the patient had lymphadenopathy. The patient did not have any cutaneous lesions. Genital examination revealed melena. A normal cranial and abdomen, thorax CT was obtained. The patient was intubated because of respiratory failure and unstable hemodynamics. The patient developed pancytopenia as a result of blood tests. The patient died due to massive lower gastrointestinal bleeding.
”Gör plats!”
Authors: Apelmo Elisabet , Alftberg Åsa
Published: January 2023

”Make room!” Concerning ableism, paternalism and the construction of dis/ability Within the social work profession, social vulnerability and social justice are central concerns. However, professional emphasis is on economic and social conditions and less on dis/ability, despite the fact that dis/ability is important, not only for services aimed specifically at people with dis/abilities, but the entire profession of social work is linked to dis/ability in various ways. The purpose of the article is to contribute to a deepened understanding of vulnerability in general and, in particular, the vulnerability of people with dis/abilities. An advertisement from the Swedish Public Employment Service’s campaign “Make room!” forms a point of departure for a theoretical discussion of how dis/ability is constructed.  The article demonstrates how the advertisement is based on paternalistic and ableistic ways of thinking that connect dis/ability, gender, and race/ethnicity. Able-bodied perfection is regarded as desirable, while the deviant body is linked to deficiency and suffering. The article also deals with the critical discussion that followed the advertisement, which eventually led to the Swedish Public Employment Service withdrawing it.  Finally, we argue in favour of a cripistemological perspective in social work. This means taking previously marginalized knowledge as a starting point and reformulate traditional perspectives. It also means seeking cross-border cooperation between social work and the disability rights movement as well as other social movements. Thus, the lived experience of vulnerability that can result from impairment and its effects, as well as the political vulnerability that arises due to lack of resources, are made visible, without vulnerability being interpreted from paternalistic and ableistic perspectives. Moreover, ideas of the normal body and the normal way of thinking and feeling can be
Personality of individually housed dairy-beef crossbred calves is related to performance and behavior
Authors: Michalski Emily , Woodrum Setser Megan M. , Mazon Gustavo , Neave Heather W. , Costa Joao H. C.
Published: January 2023

The aim of this study was to evaluate differences in behavioral responses of individually housed dairy-beef crossbred calves to standardized personality tests (novel person, novel object, and startle test) and investigate associations of personality traits with performance and home pen behavior. Dairy-beef crossbred (Holstein x Angus) calves (n=29) were individually housed with ad libitum access to water and calf starter. Body weight was measured weekly and calf starter intake was recorded daily from day of arrival (8.5 ± 2.1; experimental day 1) for 76 days. Behavior within the home pen (eating, drinking, non-nutritive oral manipulation) and activity were recorded on experimental days 13, 32, 53, and 67 using a camera and a pedometer. The calves were subjected to standardized personality tests in their home pen at the end of the experimental period (80.7 ± 2.0 d of age), including a novel person test (stationary person in the corner of their home pen) and combined novel object/startle test (remote-controlled car in the pen, that suddenly moved when touched). A principal component analysis on the behaviors recorded from the tests (latency to approach person or object, time spent attentive and touching the person or object, and time spent inactive, playing and grooming) yielded 3 factors that explained 76.1% of the variance, and were interpreted as personality traits labeled “fearful”, “inactive”, and “bold”. These factors were examined in regression analyses for their associations with home pen behavior and performance. The factor “fearful” had negative associations with total average daily gain and average grain intake. In contrast, the factor “inactive” had positive associations with non-nutritive oral manipulation of buckets or walls. The factor “bold” had no significant association with any of the performance or home pen behavior measures. In conclusion, personality traits identified from standardized tests were related to performance and home pen behavior measures in individually housed, crossbred calves. These results complement work in group housed calves suggesting personality testing may be useful selective tools to identify high and low performing calves from an early age.
Bismuth-coated 80S15C bioactive glass scaffolds for photothermal antitumor therapy and bone regeneration
Authors: Du Jianhang , Ding Huifeng , Fu Shengyang , Li Dejian , Yu Bin
Published: January 2023

Background: Malignant bone tumors usually occur in young people and have a high mortality and disability rate. Surgical excision commonly results in residual bone tumor cells and large bone defects, and conventional radiotherapy and chemotherapy may cause significant side effects. In this study, a bifunctional Bi-BG scaffold for near-infrared (NIR)-activated photothermal ablation of bone tumors and enhanced bone defect regeneration is fabricated.

Methods: In this study, we prepared the Bi-BG scaffold by in-situ generation of NIR-absorbing Bi coating on the surface of a 3D-printing bioactive glass (BG) scaffold. SEM was used to analyze the morphological changes of the scaffolds. In addition, the temperature variation was imaged and recorded under 808 nm NIR laser irradiation in real time by an infrared thermal imaging system. Then, the proliferation of rat bone mesenchymal stem cells (rBMSCs) and Saos-2 on the scaffolds was examined by CCK-8 assay. ALP activity assay and RT-PCR were performed to test the osteogenic capacity. For in vivo experiments, the nude rat tumor-forming and rat calvarial defect models were established. At 8 weeks after surgery, micro-CT, and histological staining were performed on harvested calvarial samples.

Results: The Bi-BG scaffolds have outstanding photothermal performance under the irradiation of 808 nm NIR at different power densities, while no photothermal effects are observed for pure BG scaffolds. The photothermal temperature of the Bi-BG scaffold can be effectively regulated in the range 26–100°C by controlling the NIR power density and irradiation duration. Bi-BG scaffolds not only significantly induces more than 95% of osteosarcoma cell death (Saos-2) in vitro, but also effectively inhibit the growth of bone tumors in vivo. Furthermore, they exhibit excellent capability in promoting osteogenic differentiation of rBMSCs and finally enhance new bone formation in the calvarial defects of rats.

Conclusion: The Bi-BG scaffolds have bifunctional properties of photothermal antitumor therapy and bone regeneration, which offers an effective method to ablate malignant bone tumors based on photothermal effect.
Virus-like nanoparticles as a theranostic platform for cancer
Authors: Kim Kyeong Rok , Lee Ae Sol , Kim Su Min , Heo Hye Ryoung , Kim Chang Sup
Published: January 2023

Virus-like nanoparticles (VLPs) are natural polymer-based nanomaterials that mimic viral structures through the hierarchical assembly of viral coat proteins, while lacking viral genomes. VLPs have received enormous attention in a wide range of nanotechnology-based medical diagnostics and therapies, including cancer therapy, imaging, and theranostics. VLPs are biocompatible and biodegradable and have a uniform structure and controllable assembly. They can encapsulate a wide range of therapeutic and diagnostic agents, and can be genetically or chemically modified. These properties have led to sophisticated multifunctional theranostic platforms. This article reviews the current progress in developing and applying engineered VLPs for molecular imaging, drug delivery, and multifunctional theranostics in cancer research.
Low-Intensity Pulsed Ultrasound Promotes Osteogenic Potential of iPSC-Derived MSCs but Fails to Simplify the iPSC-EB-MSC Differentiation Process
Authors: Hua Ziyi , Li Shuang , Liu Qianzi , Yu Minxuan , Liao Mengling , Zhang Hongmei , Xiang Xuerong , Wu Qingqing
Published: January 2023

Graphical Abstract

We demonstrate LIPUS at the intensity of 40mW/cm2 and the D.C of 50% (LIPUS40/50) can enhance the osteogenic potential of iMSCs in vitro and in vivo. LIPUS40/50 seems to accelerate EB-iMSC transition, but itfails to convert iPSCs or EB cells into osteoblasts directly. These results represent an important step toward applying iPSCs safely and effectively in bone tissue engineering.