bluuebunny/crossref_metadata_2025 huggingface dataset:
Adolescent and Young Adult Initiated Discussions of Advance Care Planning: Family Member, Friend and Health Care Provider Perspectives
Authors: Bedoya Sima Z. , Fry Abigail , Gordon Mallorie L. , Lyon Maureen E. , Thompkins Jessica , Fasciano Karen , Malinowski Paige , Heath Corey , Sender Leonard , Zabokrtsky Keri , Pao Maryland , Wiener Lori
Published: June 2022

Background and Aims

End-of-life (EoL) discussions can be difficult for seriously ill adolescents and young adults (AYAs). Researchers aimed to determine whether completing Voicing My CHOiCES (VMC)—a research-informed advance care planning (ACP) guide—increased communication with family, friends, or health care providers (HCPs), and to evaluate the experience of those with whom VMC was shared.

Methods

Family, friends, or HCPs who the AYAs had shared their completed VMC with were administered structured interviews to assess their perception of the ACP discussion, changes in their relationship, conversation quality, and whether the discussion prompted changes in care. Open-ended responses underwent thematic analysis.

Results

One-month post-completion, 65.1% of AYA had shared VMC completion with a family member, 22.6% with a friend, and 8.9% with an HCP. Among a sample of respondents, family (47%) and friends (33%) reported a positive change in their relationship with the AYA. Participant descriptions of the experience fell into five themes: positive experience (47%), difficult experience (44%), appreciated a guide to facilitate discussion (35%), provided relief (21%), and created worry/anxiety (9%). Only 1 HCP noted a treatment change. Family (76%), friends (67%), and HCP (50%) did not think the AYA would have discussed EoL preferences without completing VMC.

Conclusions

VMC has potential to enhance communication about ACP between AYA and their family and friends, though less frequently with HCPs. Participants reported a positive change in their relationship with the AYA after discussing VMC, and described experiencing the conversation as favorable, even when also emotionally difficult.
How Does the Parent–Adolescent Relationship Affect Adolescent Internet Addiction? Parents’ Distinctive Influences
Authors: Qi Huaiyuan , Kang Qinhong , Bi Cuihua
Published: June 2022

Although previous research has demonstrated that parent–adolescent relationships have a significant effect on adolescent Internet Addiction (IA), the mechanisms underlying these associations and parental differences in these effects have received insufficient attention. We investigated the mediating role of Perceived Social Support and Dual System of Self-Control (DSSC) in the relationship between Father-Adolescent Relationships/Mother-Adolescent Relationships (FAR/MAR) and adolescent IA, as well as the differences in the effects of FAR and MAR. A cross-sectional survey of 732 Chinese adolescents was conducted using the Adolescent Pathological Internet Use Scale, Parent–Adolescent Relationship Scale, Multidimensional Scale of Perceived Social Support, and Dual System of Self-Control Scale. Multiple linear regression analysis, Pearson correlation analysis and structural equation modeling were used. The results of structural modeling analysis showed that neither FAR nor MAR directly predicted adolescent IA. In contrast, FAR/MAR had an impact on adolescent IA mainly through the mediating effects of Perceived Social Support and Impulsive System. Furthermore, in the relationship between FAR/MAR and adolescent IA, the Impulsive System and Perceived Social Support both served as chain mediators, as did Perceived Social Support and the Reflective System. And more importantly, unlike FAR, MAR affects adolescent IA through the mediating effect of the Reflective System. Multiple linear regression showed that the regression coefficient of MAR on adolescent IA had stronger significance compared to FAR, MAR is deserving of more attention than FAR. These findings contribute to our understanding of the mechanisms underlying the association between FAR/MAR and adolescent IA and suggest that family relationship-focused training approaches are critical for suppressing adolescent IA. These interventions should be tailored to the unique circumstances of each family.
Assessing Protected Area Zoning Effectiveness With Remote Sensing Data: The Case of Nahuel Huapi National Park, Argentina
Authors: Rivarola María Daniela , Dein Jacob , Simberloff Daniel , Herrero Hannah Victoria
Published: June 2022

Protected areas (PAs) remain the most important tool to prevent biodiversity loss and habitat degradation worldwide, but the formal creation of a PA constitutes only the first step. In recent decades, concerns about PA effectiveness have arisen, and several PAs have been evaluated using different methods. Results show that while some PAs are achieving their conservation goals, others have been less effective. Particularly, assessing broadscale outcomes is a method that allows us to monitor change over time at a large scale, using remote sensing data. In this study, we evaluated the effectiveness of Nahuel Huapi National Park, with particular attention to its three protection categories: Strict Natural Reserve (SNR), National Park (NP), and National Reserve (NR) (IUCN categories Ia, II, and VI respectively). We compared changes in Normalized Difference Vegetation Index (NDVI) among sites in these categories and between them and neighboring unprotected areas, over the period 2000–2020. Overall, habitat degradation was low, and we found no difference among the four categories evaluated. Nevertheless, a greening process has been conspicuous in the entire area, with higher values both in the SNR and in the unprotected area. We propose possible explanations as we consider variables such as dominant tree species, precipitation, temperature, elevation, and wildfires. This study supports the importance of NHNP at the regional and national levels, particularly its SNR areas.
Surgical Site Infection Following Single-Port Appendectomy: A Systematic Review of the Literature and Meta-Analysis
Authors: Köhler Franziska , Reese Lena , Kastner Carolin , Hendricks Anne , Müller Sophie , Lock Johan F. , Germer Christoph-Thomas , Wiegering Armin
Published: June 2022

Introduction

Surgical site infections (SSIs) are one of the most common postoperative complications after appendectomy leading to recurrent surgery, prolonged hospital stay, and the use of antibiotics. Numerous studies and meta-analyses have been published on the effect of open versus conventional laparoscopic appendectomy (CLA) reporting faster postoperative recovery and less postoperative pain for CLA. A development from CLA has been the single-port appendectomy (SPA), associated with a better cosmesis but seemingly having a higher risk of wound infections. The aim of this systematic literature review and meta-analysis is to investigate whether reduced port or SPA alters the ratio of SSIs.

Methods

Pubmed, Embase, and Cochrane databases were screened for suitable articles. All articles published between January 1, 2002, and March 23, 2022, were included. Articles regarding children below the age of 18 were excluded as well as manuscripts that investigated solemnly open appendectomies. Articles were screened for inclusion criteria by two independent authors. Incidence of SSI was the primary outcome. Duration of operation and length of hospital stay were defined as secondary outcomes.

Results

A total of 25 studies were found through a database search describing 5484 patients. A total of 2749 patients received SPA and 2735 received CLA. There was no statistical difference in the rate of SSI (P = 0.98). A total of 22 studies including 4699 patients reported the duration of operation (2223 SPA and 2476 CLA). There was a significantly shorter operation time seen in CLA. The length of hospital stay was reported in 23 studies (4735 patients: 2235 SPA and 2500 CLA). A shorter hospital stay was seen in the SPA group (P < 0.00001). Separately performed analysis of randomized controlled trials could not confirm this effect (P = 0.29).

Discussion

SPA is an equally safe procedure considering SSI compared to CLA and does not lead to an increased risk of SSI. A longer operation time for SPA and a minor difference in the length of stay does lead to the use of SPA in selected patients only.
A Combination of Lactic Acid Bacteria and Molasses Improves Fermentation Quality, Chemical Composition, Physicochemical Structure, in vitro Degradability and Rumen Microbiota Colonization of Rice Straw
Authors: Chen Xu , Ma Yulin , Khan Muhammad Zahoor , Xiao Jianxin , Alugongo Gibson Maswayi , Li Shengli , Wang Yajing , Cao Zhijun
Published: June 2022

Aims

This study aims to evaluate the effect of lactic acid bacteria (LAB) and LAB-molasses (LAB + M) combination on the fermentation quality, chemical composition, physicochemical properties, in vitro degradability of rice straw and the characteristics of rumen microbial colonization on rice straw surface.

Methods and Results

There were three pretreatments, including control (not treated, Con), treated with LAB, or LAB + M. The results showed that both LAB and LAB + M treatments altered the physical and chemical structures of rice straw and were revealed by scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD) spectroscopy, respectively. Moreover, both LAB and LAB + M pretreated rice straw increased the crude protein (CP) content, dry matter (DM) recovery, and in vitro digestibility and decreased the pH value, neutral detergent fiber (NDF), and acid detergent fiber (ADF) contents. The LAB + M pretreated rice straw increased the gas production (GP72) and rumen microbial colonization on the rice straw surface.

Conclusions

It is observed that LAB + M treatment could increase digestibility and the rumen microbial colonization on the rice straw surface. Therefore, LAB + M treatment can provide an alternative strategy to improve the quality of rice straw. Significance and impact of the study: This study provides an optimal pretreatment to improve the rice straw digestibility and rumen microbial colonization.
PENGARUH VARIASI WAKTU DAN SUHU INKUBASI METIL SALISILAT SEBAGAI CLEARING AGENT TERHADAP KUALITAS PREPARAT JARINGAN LIPOSARKOMA
Authors: Wiryanti Wiwin , Yohana Dein , Durachim Adang , Mahmud Dani
Published: June 2022

Liposarkoma adalah neoplasma ganas dengan diferensiasi adiposit. Salah satu subtipe dari liposarkoma adalah atypical lipomatous tumour yang secara makroskopik memiliki ukuran yang relatif besar, sedangkan secara mikroskopik sangat mirip dengan sel lemak normal. Jaringan yang mengandung lemak mempunyai sifat yang sulit ditembus oleh cairan fiksatif pada proses pematangan jaringan sehingga memungkinkan terjadinya prosesing jaringan yang tidak sempurna. Salah satu tahap pematangan jaringan yang berpengaruh terhadap kualitas preparat adalah clearing. Xylol merupakan agen clearing yang umum digunakan. Karena sifatnya berbahaya dan toksik maka digunakan agen clearing lain. Metil salisilat digunakan sebagai clearing agent karena bersifat non polar yang dapat melarutkan lemak. Selain itu, metil salisilat juga dapat larut dengan agen dehidrasi dan dapat larut dengan parafin sehingga dapat mengeraskan jaringan. Tujuan penelitian ini adalah untuk mengetahui apakah ada pengaruh variasi waktu dan suhu inkubasi metil salisilat sebagai clearing agent serta mengetahui perbedaannya dengan xylol menggunakan metode kuasi eksperimen. Sampel menggunakan organ jaringan mencit yang telah diinduksi dengan sel tumor liposarkoma sebanyak 75 preparat dari 5 blok. Parameter yang digunakan adalah interpretasi kualitas preparat berupa pengukuran intensitas warna inti dan sitoplasma menggunakan software ImageJ serta kejelasan membran sel oleh dokter patologi anatomi. Hasil penelitian menunjukan bahwa terdapat pengaruh waktu dan suhu inkubasi metil salisilat terhadap kualitas preparat jaringan liposarkoma dan tidak terdapat perbedaan kualitas intensitas warna inti dan membran sel dibandingkan dengan xylol. Saran penelitian adalah menemukan waktu dan suhu yang optimal untuk kesempurnaan metil salisilat sebagai clearing agent sehingga mendapatkan kualitas preparat yang baik.
Resposta cardiorrespiratória de paraplégicos pelo teste de membro superior: série de casos
Authors: Floripes de Souza Meretica Larissa , Souza Danielly Fernanda de , Silva Juliana Fernandes da , Nascimento Luisa Kulkamp do , Fernandes Maria Vitória Fabrini , Silva Beatriz Almeida , Rodrigues Dionatan Costa , Méndes Maria Verónica Gonzáles , Moraes Gabriela Fóz , Souza Roger Burgo de
Published: June 2022

Introdução. Indivíduos com lesão da medula espinal (LME) apresentam alterações da capacidade cardiorrespiratória e importante estresse dos membros superiores durante as atividades. Objetivo. Analisar as respostas cardiorrespiratórias de indivíduos paraplégicos submetidos ao teste de exercício de membros superiores sem apoio (UULEX). Método. Séire de casos com quatro indivíduos paraplégicos, nível neurológico T4 e T10.  Todos os participantes realizaram o teste UULEX. As variáveis frequência cardíaca (FC), frequência respiratória (FR), pressão arterial sistólica (PAS), pressão arterial diastólica (PAD), Escala de Borg fadiga (BF) e Borg dispneia (BD) foram coletadas antes e após teste. Resultados. A maioria das variáveis alteraram seus valores após o UULEX. Conclusão. As respostas cardiorrespiratórias encontradas foram compatíveis com respostas fisiológicas normais durante uma atividade física.
EFFECTIVENESS OF ULTRASONIC IRRIGATION ON CALCIUM HYDROXIDE REMOVAL WITH DIFFERENT SOLUTIONS: AN IN VITRO STUDY
Authors: Nguyen Duc Quynh Trang , Nguyen Thi Thuy Duong
Published: June 2022

Background: Calcium hydroxide has been widely used in endodontics as an intracanal medicament. Before obturation, calcium hydroxide, an intracanal medicament should be completely removed from the root canal system sinceresidual calcium hydroxide might adversely affect the outcome of endodontic treatment results. Various irrigation techniques to remove this intracanal medicament have developed. The aim of this in vitro study was to evaluate the effectiveness in removing calcium hydroxide from the root canal, with or without using ultrasonic activation. Materials and methods: Sixty extracted single-rooted mandibular premolar were instrumented using ProTaper rotary instruments, filled with calcium hydroxide and divided into six groups (n=10/group). Subsequently, calcium hydroxide was removed by six different protocols. Group I, II, II were flushed using 2.5% NaOCl, 17% EDTA, 10% citric acid, respectively. Group IV, V, VI were flushed using the same irrigants respectively with ultrasonic activation. Finally, the roots were grooved longitudinally and split
in two halves. Selected half of each tooth was observed under a stereomicroscope at 30x magnification to assess the residual calcium hydroxide score. Results: NaOCl 2,5% demonstrated the significantly higher score of residual calcium hydroxide than EDTA 17% and citric acid 10% (p<0.05). Groups combined with ultrasonic irrigation was significant lower than the others (p<0.05). Conclusion: None of the six techniques could remove all calcium hydroxide completely. Ultrasonic irrigation was more effective in removing calcium hydroxide than syringe delivery.
Key words: calcium hydroxide, irrigation solution, ultrasonic irrigation
INVESTIGATION ON THE PHENOTYPIC CHARACTERISTICS OF ANTIBIOTIC RESISTANCE AND SOME GENETIC CHARACTERISTICS OF KLEBSIELLA PNEUMONIAE ISOLATES CAUSING INFECTIONS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL AND KHANH HOA GENERAL HOSPITAL
Authors: Tran Thi Tuyet Ngoc , Le Thi Lan Huong , Nguyen Hoang Bach , Le Van An
Published: June 2022

Objectives: To definite antibiotic-resistant phenotypes of Klebssiella pneumoniae isolated; Identifying some virulence genes and antibiotic resistance genes in strains of Klebssiella pneumoniae isolated from clinical samples collected in infected patients. Methods: We cultured, isolated and identified Klebsiella pneumoniae. Then we definitely the sensitivity to antibiotics of bacteria by disk diffusion (Kirby-Bauer) method, definited the production of ESBL. Considering the proportion of blaNDM-1, blaKPC, blaOXA-48, magA, rmpA genes by multiplex PCR. Results: Klebssiella pneumoniae isolates were resistant to antibiotics with high proportion. All 43 isolates of Klebssiella pneumoniae with ESBL (+) had higher proportion of antibiotic resistance than ESBL (-) isolates. Klebssiella pneumoniae carried antibiotic resistance genes blaNDM-1, blaKPC, blaOXA-48 were 11%, 2%, 2%. There were 24% isolates of Klebssiella pneumoniae carring virulence genes rmpA, 9% of them carring magA gene. Conclusions: Klebssiella pneumoniae is highly resistant to many antibiotics. Especially Klebssiella pneumoniae isolates ESBL (+). The proportion of Klebssiella pneumoniae carrying the antibiotic resistance blaNDM-1, blaKPC, blaOXA-48 genes were 11%, 2%, 2%. The proportion of carrying the virulence magA, rmpA genes is 24% and 9%.
Key words: Klebsiella pneumonia, antibiotic resistant, PCR
FACTORS RELATED TO THE RESULTS OF SURGICAL TREATMENT OF ZYGOMATIC FRACTURES WITH MINIPLATES
Authors: Huynh Van Tanh , Tran Tan Tai
Published: June 2022

Background: Fracture of the zygomatic complex is one of the most common facial injuries in maxillofacial trauma and mainly caused by traffic accidents. The objective of this study was to investigate the factors related to the results of surgical treatment of zygomatic fractures with miniplates. Subjects and Methods: 46 patients (average age 34.24 ± 15.16) were diagnosed with zygomatic fractures. All of patients were operated and treated with titanium miniplates. This study assessed the general treatment results of: anatomy, aesthetics and function at the time of discharge, 3 months, 6 months postoperatively. This study also investigated the factors related to the results of surgical treatment of zygomatic fractures with miniplates. Results: Factors
associated with post-operative results include: Clinical manifestations: restricted mouth opening, maxillary sinus fracture (p<0.05) X-ray: number of fracture lines (≥ 4 lines) and type IV fracture (p<0.01); overlapping fracture; comminuted fracture; depressed fracture (p<0.05); number of miniplates used: ≥ 2 (p<0.05). Conclusions: Evaluating factors related to surgical results helps clinicians evaluate and make prognosis in order to develop treatment plan in time and minimize complications after surgery.
Key words: Fracture of the zygomatic complex; Affecting factors; Internal fixation with miniplates
A STUDY ON SERUM IRON, TRANSFERRIN AND FERRITIN LEVELS IN NEPHROTIC SYNDROME PATIENTS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Le Van An , Le Chuyen , Duong Thi Ngoc Lan , Pham Thi Thuy Vu , Nguyen Thi Thu Thao , Vo Hoang Lam
Published: June 2022

Background: The prolonged and excessive loss of protein through urine in nephrotic syndrome patients decreases blood protein and leads to other changes such as dyslipidemia, disorders of blood components, hematopoiesis…., if the blood albumin level decreases continuously, the more obvious these disorders, the serum iron, transferrin and ferritin levels will be changing. The aim of the study was to determine the concentrations of serum iron, transferrin, ferritin in nephrotic syndrome patients and the relation between these parameters. Materials and methods: Descriptive cross-sectional studies of 68 patients with the diagnosis of nephrotic syndrome and without renal failure. Results: The mean concentration of serum iron was 8.9 μmol/L, with the low level was 30.9%. While the serum transferrin which was lower than normal was 100% and the mean concentration was 0.68 mmol/L. The mean concentration of serum ferritin was 610.3 pmol/L, and its high level was 67.6%. Conclusions: Concentration of serum ferritin was elevated and inversely correlated with serum iron and transferrin concentrations.
Key words: iron, transferrin, ferritin, nephrotic syndrome
PERIODONTAL STATUS IN HYPERTENSIVE PATIENTS AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Tran Tan Tai , Doan Thi Van Khanh , Ho Sy Minh Duc , Nguyen Thi Thuy Hang
Published: June 2022

Background: Hypertension is one of the major causes of cardiovascular diseases in the world. Periodontal disease is a chronic inflammatory disorder of the tissues surrounding the teeth. Previous studies found that there is a biological relationship between hypertension and periodontitis since both diseases share some common risk factors. The objectives of this study were to determine the association between hypertension and periodontal parameters in periodontitis patients. Subjects and Method: A cross-sectional study of 100 hypertensive patients who visited the Department of Cardiology at the Hue University of Medicine and Pharmacy Hospital. Clinical examination of periodontal indices and interview about the history of hypertension for all study subjects. Results: Average results of periodontal indices of hypertensive patients are: plaque index (PlI) 1.83 ± 0.44, gingival index (GI) 1.20 ± 0.39, periodontal pocket depth (PPD) 2.72 ± 0.42 mm, clinical attachment loss (CAL) 2.03 ± 1.50 mm; The rate of periodontitis in hypertensive patients is 74% with proportion of moderate, severe and mild level are 34%, 26% and 13% respectively; duration of hypertension and periodontal indices of the patients are also positively correlated (p<0.05).There was a statistically significant relationship between periodontal status and blood pressure index (p <0.05). Conclusion: There is a possible association between periodontal disease and hypertension. Therefore, further investigation is recommended thus will help in managing oral and systemic health diseases.
Key words: hypertension, periodontal diseases, oral health
VIETNAMESE ANESTHESIOLOGISTS TRAINING ABOUT EMERGENCY FRONT OF NECK ACCESS IN THE CANNOT INTUBATE - CANNOT OXYGENATE CRISIS
Authors: Dam Thi Phuong Duy , Nguyen Van Minh , Choyce Andrew , Ko Sara
Published: June 2022

Background: Emergency front of neck access (eFONA) is the last resort in the Cannot Intubate - Cannot Oxygenate (CICO) crisis. The presence of an algorithm and a well-trained team have been recognized as being essential in reducing errors to achieve a positive outcome. The objective of this study was to evaluate the current situation regarding training, experience and availability of the various means of managing CICO and eFONA in Vietnamese hospitals. Methods: We sent out a link for a 10-question electronic survey to lead anaesthesiologists who subsequently distributed the link to their staff. This was followed by a paper questionnaire at the anaesthesia conference in Hue City. Results: 49.3% of anesthetists are aware of local guidelines in their hospital compared to 69.5% being aware of international guidelines. Only 90 (29.8%) respondents felt they could manage the CICO/eFONA crisis with confidence. Some form of training in managing a CICO crisis has been received by two thirds of respondents (203, 67.2%). Only 88 (29.1%) respondents had received any hands-on simulation training. The majority of participants agreed that some form of compulsory training for CICO/eFONA would be appropriate (98.7%, 298/302). Conclusion: There was a shortage in training, the experience of anesthetists and availability of the various means of managing CICO and eFONA in Vietnamese hospitals. Simulation training should play a vital part in this situation
Key words: CICO, eFONA, training and equipment
EARLY ASSESSMENT THE EFFECT OF INTRAARTICULAR AUTOSOMAL PLATELET-RICH PLASMA INJECTION IN THE PRIMARY KNEE OSTEOARTHRITIS TREATMENT
Authors: Pham Minh Trai , Nguyen Hoang Thanh Van
Published: June 2022

Introduction/Background: Osteoarthritis is a degenerative joint disease that commonly occurs in the elderly population. Treatment goals include pain relief, improvement in knee function, improved quality of life and reduction in disability. Several studies describe the use of biological therapies such as autosomal plateletrich plasma as effective and safe methods in the treatment of pain and joint dysfunction caused by knee osteoarthritis. Objectives: To evaluate the analgesic, mobility functional improvement efficacy, and safety of intraarticular autosomal platelet-rich plasma (PRP) injection in the primary knee osteoarthritis treatment. Materials and Methods: Prospective descriptive study of 38 knee joints of 31 patients was diagnosed with primary osteoarthritis according to the American College of Rheumatology (ACR) classification criteria and in
Kellgen & Lawrence grade II, III. The patient was assessed about clinical features, subclinical features and the VAS score, Lequesne index at the initial of the study and 30 days later. Results: The VAS score at 30 days postinjection of PRP lower than the initial value with a statistically significant difference (40.55 ± 9.65 and 65.71 ± 10.06, respectively, with p < 0.001). The Lequesne index at 30 days post-injection of PRP lower than the initial value with a statistically significant difference (12.50 ± 2.64 and 16.74 ± 2.40, respectively, with p < 0.001). The improvement of VAS score and Lequesne index is better in the patient with Kellgren & Lawrence grade II than those with Kellgren & Lawrence grade III (27.24 ± 6.55 and 22.59 ± 5.95, respectively, with p < 0.05). The incidence of the observed complications was not reported in this study. Conclusions: The intraarticular PRP injection in the primary knee osteoarthritis treatment is a safe approaching and has a significant effect
on pain relief and physical function improving after 30 days. The improvement of the VAS score and Lequesne index is greater in the patient with the early grade on Kellgren & Lawrence classification.
Key words: Knee osteoarthritis, intraarticular injection, autosomal platelet-rich plasma, PRP.
ATLARDA EGZERSİZİN NİTRİK OKSİT, İNTERLÖYKİN-10 DÜZEYLERİ VE KASPAZ-6 AKTİVİTESİ İLE BAZI BİYOKİMYASAL PARAMETRELERE ETKİSİ
Authors: DEMİREL Mehmet , EREN Meryem , ŞENTÜRK Meryem
Published: June 2022

Bu çalışmada, 20 adet Safkan İngiliz atlarında egzersizin bazı biyokimyasal parametrelerin yanında oksidatif stres göstergelerinden nitrik oksit (NO), temel inflamatuvar sitokinlerden interlöykin-10 (IL-10) düzeyleri ve apoptoz belirteçlerinden kaspaz-6 aktivitesi üzerindeki etkileri belirlendi. Bu amaçla atlar, 10 günlük süre boyunca 11:00 ve 13:00 saatleri arasında günde bir kez egzersize tabi tutuldu. Egzersiz öncesi ve sonrası hayvanların v. jugularisinden kanları alınıp, elde edilen serumlarda aspartat amino transferaz (AST), laktat dehidrojenaz (LDH), kreatin kinaz (CK) enzim aktiviteleri ile glikoz, toplam kolesterol, trigliserid, albümin, üre ve kreatinin, plazmalarda NO, IL-10 düzeyleri ile kaspaz-6 aktiviteleri belirlendi. Egzersiz; serum AST, LDH, CK, plazma kaspaz-6 aktiviteleri ile IL-10 ve serum albümin düzeylerini etkilemedi. Bununla birlikte egzersize bağlı olarak, her ne kadar referans değerler arasında olmakla birlikte, serum glikoz düzeylerinde düşme, toplam kolesterol, trigliserid, üre, kreatinin ve plazma NO düzeylerinde ise yükselme saptandı. Sonuç olarak; yarış atlarında incelenen biyokimyasal parametreler, oksidatif stres, sitokin ve apoptoz belirteçlerinin egzersiz süresi, türü ve yoğunluğuna bağlı olarak değişebileceği kanaatine varıldı.
EBELERİN YETKİLERİ HAKKINDA GÖRÜŞLERİ; NİTEL BİR ÇALIŞMA
Authors: GÖKDUMAN KELEŞ Mine , ALTİNKAYA S.ozlem
Published: June 2022

Bu araştırmanın amacı ebelerin yetkileri ilgili görüşlerini değerlendirmek amacıyla yapılmıştır. Nitel araştırma yöntemi tekniklerinden görüşme tekniği kullanılmış olup fenomenolojik bir araştırmadır. Örneklemi; maksimum çeşitlilik örnekleme tekniğiyle belirlenen Türkiye’nin Akdeniz bölgesinde bir şehir hastanesi doğumhane biriminde çalışan 11 ebe oluşturmuştur. Veriler yarı yapılandırılmış form ile bireysel görüşme ve ses kaydı alınarak toplanmış, içerik analizi yoluyla çözümlenmiştir. Nitel verilerin analizi sonucu 5 tema, 12 alt tema, 38 kod oluşturulmuştur. Bu çalışmada ebeler çalıştıkları doğumhane ortamının gürültülü, yoğun, stresli olarak bildirmişlerdir. İlaveten mesleklerini severek yaptıklarını, anne ve bebek sağlığından sorumlu olduklarını dile getirmişlerdir. Ayrıca ebelerin yetkilerini; gebeyi karşılama, gebenin yatışını yapma, gebenin ilk değerlendirmesini yapma, gebeye tedaviyi uygulama, doğum öncesi takibini yapma, doğum yaptırma ve doğum sonrası bir saat anne ve bebek takibi olarak belirtmişlerdir. Ebeler doğumhaneye yatış yapma, reçete yazma, indüksiyon uygulama yetkilerinin kendilerine tanımlanmasının uygun olacağını da düşünmektedirler. Ebelerin belirttiği yetki alanlarının; Sağlık Meslek Mensupları ile Sağlık Hizmetlerinde Çalışan Diğer Meslek Mensuplarının İş ve Görev Tanımlarına Dair Sayı: 29007 ve 2014 belirlediği Yönetmeliği’nin yetkinlik alanlarıyla orantılı olduğu saptanmıştır. Lisans eğitimlerinde ve hizmet içi eğitimlerde ebelerin yetkilerine yönelik eğitimler verilerek bilgilerinin güncellenmesi sağlanmalıdır. Ebeliği kapsayan yasa ve yönetmeliklerde düzenlemeler yapılmalıdır. Bu düzenlemelerde ebelerde zorunlu mesleki sorumluluk sigortası da dâhil edilmelidir.
GERİATRİK BİREYLERDE POLİFARMASİ VE KARDİYAK RİSK FAKTÖRLERİNİN DENGE, DÜŞME VE FONKSİYONEL BAĞIMSIZLIĞA ETKİSİNİN İNCELENMESİ
Authors: KIZILKAYA Nurettin , SAKA Seda
Published: June 2022

Geriatrik popülasyonda, hastaların fonksiyonelliği, denge ve düşme problemleri önemli bir yer tutmaktadır. Diğer taraftan geriatrik bireylerde kardiyak risk artmış, polifarmasi ise çok yaygındır. Çalışmamızda geriatrik bireylerde polifarmasinin ve kardiyak risk faktörlerinin denge, düşme ve fonksiyonel bağımsızlıkla ilişkisinin incelenmesi amaçlanmıştır. Çalışmaya bağımsız yürüyebilen ve sözel iletişim kurabilen 64 geriatrik gönüllü birey dahil edilmiştir. Katılımcıların demografik bilgileri ve kardiyak risk faktörleri kaydedilmiştir. Kardiyak risk skoru hesaplamasında Joint British Societies risk hesap cetveli kullanılmıştır. Kognitif durum değerlendirmesi için Mini Mental Durum Skalası (MMDS), fiziksel aktivite düzeyinin değerlendirilmesi için Yaşlılar için Fiziksel Aktivite Ölçeği (PASE), günlük yaşam aktivitelerinde bağımsızlık düzeyini belirlemek için Fonksiyonel Bağımsızlık Ölçeği (FBÖ), dengenin değerlendirilmesi için Berg Denge Ölçeği (BDÖ) ve düşme riskinin belirlenmesi için Tinetti Denge ve Yürüme Testi (TDYT) kullanılmıştır. Katılımcıların yaş ortalaması 80.46±8.22, vücut kütle indeksi (VKİ) ortalaması ise 26.09±14.47 olarak belirlenmiştir.Çalışmaya katılanların %51.6’sı erkek %48.4’ü kadındır. Korelasyon analizinde ise polifarmasi değerleri ile FBÖ, BDÖ, TDYT ve PASE değişkenleri arasında negatif yönlü orta düzey anlamlı ilişki bulunmuştur (p<0.05). Kardiyak risk skoru ile PASE, FBÖ, BDÖ, TDYT, arasında istatistiksel olarak anlamlı ilişki bulunmamıştır (p˃0.05). Çalışmamızda, geriatrik bireylerde polifarmasinin denge, düşme ve fonksiyonel bağımsızlığı olumsuz yönde etkilediği ve kardiyak risk skorunun denge, düşme ve fonksiyonel bağımsızlığa etkisinin olmadığı belirlenmiştir. Geriatrik popülasyonda sağlık hizmetlerinin sunumunda, denge, düşme problemleri ve fonksiyonel bağımsızlığa yönelik yaklaşımlar planlanırken polifarmasi ve kardiyak risklerin dikkate alınmasının uygulamaların etkinliğini artıracağı öngörülmektedir.
Patologias no concreto armado em elementos de projetos estruturais: uma revisão / Pathologies in reinforced concrete in elements of structural projects: a review
Authors: Silva Maria Eduarda de Almeida , Da Silva Elzelis Muller , Quaresma Danielly da Silva , Nunes Lucas Mateus Coelho , Passos Inaray de Sousa , Cordeiro Débora Reis , Caldas Ágata Maise de Jesus , Ogorodnik Maria Eduarda Assunção
Published: June 2022

Embora os avanços tecnológicos na área da engenharia civil tenham avançado , muitas estruturas apresentam um desempenho não satisfatório, devido a erros de projeto, má qualidade dos materiais, falta de manutenção e dentre muitos outros fatores que contribuem para a degradação da estrutura. Portanto, o presente estudo apresenta as patologias no concreto armado que ocorrem nos principais grandes elementos de projeto estrutural como as fundações, as lajes, as vigas e os pilares.  Geralmente as manifestações patológicas apresentam características comuns que permitem aos especialistas determinar a origem que conduziram ao surgimento, a causa e as consequências para a estrutura caso não haja intervenção corretiva.  Através de revisão bibliográfica o estudo apresenta as seguintes patologias, a corrosão, as fissuras, o concreto segregado ou mal vibrado e o desgaste superficial do concreto,  bem como sua origem, causa, e seus tipos .Além disso, apresenta os tratamentos para reforçar estruturas que apresentam patologias, de modo a trazer segurança e durabilidade à estrutura. Também ressalta-se a importância da prevenção e manutenção das estruturas , sob fiscalização eficiente  e do controle de qualidade de todas as áreas envolvidas nos projetos de construção civil, ou seja, todas as áreas do processo de construção pautadas na viabilidade social, econômica e ambiental.
Monogenic Diabetes Associated with the Glucose Gene Mutation: a Clinical Case of Early Diagnosis and a Brief Review of Literature
Authors: Солнцева А.В. , Беляева Е.А.
Published: June 2022

Сахарный диабет взрослого типа у молодых (MODY) является наиболее распространенной формой моногенного диабета. Заболевание возникает в результате мутации одного из генов, которые участвуют в синтезе и секреции инсулина. На сегодняшний день выделено 14 подтипов MODY, классифицированных по этиологической мутации. Один из часто встречающихся вариантов заболевания вызван инактивирующей мутацией гена фермента глюкокиназы. Для него характерна бессимптомная гипергликемия натощак, которая в большинстве случаев выявляется при проведении профилактических осмотров. Секреция эндогенного инсулина остается сохранной. При лабораторном исследовании уровни антител к различным структурам островковых клеток ниже диагностического значения. Окончательный диагноз верифицируется на основании молекулярно-генетического исследования.Значительная вариабельность клинико-лабораторных показателей пациентов затрудняет своевременную постановку диагноза. Раннее выявление заболевания позволяет выбрать рациональную тактику наблюдения и лечения.

Maturity onset diabetes of the young (MODY) is the most common form of monogenic diabetes. The disease occurs as a result of a mutation in one of the genes involved in the synthesis and secretion of insulin. To date, 14 MODY subtypes have been identified, classified by etiological mutation. One of the most common variants of the disease is caused by an inactivating mutation of the glucokinase gene. It is characterized by asymptomatic fasting hyperglycemia, which in most cases is detected during preventive examinations. The secretion of endogenous insulin remains intact. In a laboratory study, the levels of antibodies to various structures of the islet cells are below the diagnostic value. The verification of final diagnosis based on molecular genetic research.Significant variability of clinical and laboratory parameters of patients makes it difficult to make a timely diagnosis. Early detection of the disease allows to choose a rational tactics for monitoring and treating.
Individual and Collective Memory in Ishiguro’s the Buried Giant
Authors: GÜROVA Ercan
Published: June 2022

Kazuo Ishiguro’s seventh novel The Buried Giant (2015) investigates the concept of memory in a fantastical tale which is set in the early medieval history of the post-Roman period. In a pattern of quest, the main characters embark on a journey to accomplish their mission. As for Axl and Beatrice, an elderly couple, it is to find their son and recall their lost memories. For Wistan, a Saxon warrior, it is to terminate the she-dragon named Querig whose magical breath causes a mist of forgetfulness across the land. In a narration where individual and collective memory prove to be interconnected, the writer contemplates on loss, regret, forgetting and remembering. While the mutual dependency of the individual and collective memories are presented throughout the text, the nature of traumatic experiences and mourning process is put under the limelight. The end of the novel puts an emphasis on the question of whether remembering is a blessing or a curse for both the individual and the community or nation. In this article, therefore, brief biographical information about Kazuo Ishiguro will be first given and afterwards the interconnected of individual and collective memory will be explored with the help of scholars such as Maurice Halbwachs, Cathy Caruth and Anne Whitehead. The opportunities offered by the individual and collective recollection, as well as the dilemmas and constraits it causes will be exemplified through the main characters in the novel.
Intelectuales y mecanismos sociales en la reproducción del orden social queretano
Authors: Moreno Rubio Mónica Eugenia
Published: June 2022

Presentamos los resultados de una investigación interdisciplinaria realizada en la ciudad de Querétaro, México, sobre el orden social y sus intelectuales. Nos dimos a la tarea de rastrear a través del tiempo a partir de la segunda mitad del siglo XIX y hasta la década de los setenta del siglo XX dos elementos integrantes que forman parte del orden social hegemónico: la paz y el temor a la otredad, que se reflejan actualmente en un discurso reiterado que señala al migrante nacional residente en la ciudad como responsable de ciertos “males” que le aquejan. Identificamos a los intelectuales de dicho orden y analizamos que, a través de ciertos mecanismos sociales, reprodujeron y operaron estos elementos en distintos acontecimientos de relevancia histórica local, logrando su hegemonía a través del tiempo.
Türkiye’de Etkin Bir Tsunami Erken Uyarı Sistemi ve Tsunami Risk Azaltımı İçin Gereksinimler
Authors: NECMİOĞLU Öcal
Published: June 2022

Tarihsel çalışmaların yanısıra 21 Temmuz 2017 Mw 6.6 Bodrum-Kos ve 30 Ekim 2020 Mw 6.9 Doğu Ege depremlerinin neden olduğu tsunamiler ve etkileri, ülkemizin tsunami tehlikesine açık olduğunu karşı konulamaz bir şekilde ortaya koymuş bulunmaktadır. Özellikle kıyı şeritlerindeki kentsel ve turistik yerleşimler ile endüstriyel yapılaşmaların artması, çevre ve iç denizlerimizde yaşanabilecek herhangi bir tsunaminin ülkemize olan etkileri üzerinde dikkatle durulmasını gerektirmektedir. Olası bir tsunaminin oluşması durumunda mümkün olan en kısa sürede afet acil durum yönetimi bileşenlerine ve halka erken uyarı mesajını gönderebilmek kritik önem taşımaktadır. 2015-2030 Sendai Afet Risk Azaltma Çerçevesi, afet risk yönetiminde özellikle afet riskinin anlaşılması için ulusal ve uluslararası iş birliği mekanizmalarının güçlendirilmesi adına yol gösterici bir özellik taşımakta ve yeni risklerin önlenmesini, mevcut risklerin azaltılmasını ve afetlere karşı dirençliliğin artırılmasını hedeflemektedir. Bu kapsamda belirlenen 7 küresel hedeften birisi çoklu tehlike erken uyarı sistemlerinin, afet risk bilgisinin ve değerlendirmelerinin kullanımını ve bunların toplum tarafından ulaşılabilirliğinin 2030 yılına kadar önemli ölçüde arttırılması olarak tanımlanmıştır. Bu çalışma, bir deprem ülkesi olan ülkemizde bu yaklaşım doğrultusunda Türkiye'de deprem kaynaklı tsunami erken uyarısı ve tsunami riskinin azaltılmasına ilişkin sorunlara ve önerilere odaklanmaktadır.
Consequences of Ignoring a Level of Nesting on Design and Analysis of Blocked Three-level Regression Discontinuity Designs: Power and Type I Error Rates
Authors: Bulus Metin
Published: June 2022

Multilevel regression discontinuity designs have been increasingly used in education research to evaluate the effectiveness of policy and programs. It is common to ignore a level of nesting in a three-level data structure (students nested in classrooms/teachers nested in schools), whether unwittingly during data analysis or due to resource constraints during the planning phase. This study investigates the consequences of ignoring intermediate or top level in blocked three-level regression discontinuity designs (BIRD3; treatment is at level 1) during data analysis and planning. Monte Carlo simulation results indicated that ignoring a level during analysis did not affect the accuracy of treatment effect estimates; however, it affected the precision (standard errors, power, and Type I error rates). Ignoring the intermediate level did not cause a significant problem. Power rates were slightly underestimated, whereas Type I error rates were stable. In contrast, ignoring a top-level resulted in overestimated power rates; however, severe inflation in Type I error deemed this strategy ineffective. As for the design phase, when the intermediate level was ignored, it is viable to use parameters from a two-level blocked regression discontinuity model (BIRD2) to plan a future BIRD3 design. However, level 2 parameters from the BIRD2 model should be substituted for level 3 parameters in the BIRD3 design. When the top level was ignored, using parameters from the BIRD2 model to plan a future BIRD3 design should be avoided.
РОЛЬ СУЧАСНОЇ ХУДОЖНЬОЇ УКРАЇНСЬКОЇ ПІДЛІТКОВОЇ ЛІТЕРАТУРИ У ФОРМУВАННІ ЦІННІСНИХ ОРІЄНТАЦІЙ УЧНІВ СЕРЕДНЬОГО ПІДЛІТКОВОГО ВІКУ
Authors: Мельникович Галина
Published: June 2022

У статті наголошено, що аксіологічна сутність художньої української підліткової літератури презентується природньо не нав’язливим переходом гуманістично-ціннісних орієнтацій у внутрішнє надбання особистості підлітка середнього віку. Адже саме у цьому віковому періоді, йому вкрай необхідні для наслідування, у результаті осмисленого читання, позитивні вчинки героїв художніх творів, сприйняті не лише на когнітивному й емоційному рівнях, а й у проявах власної поведінки.
Особливу увагу акцентовано на тому, що аксіологічний вплив художньої підліткової літератури набуває більшої значимості, зумовленої специфікою сприймання прочитаного підлітками середнього віку. Доведено, що визначальна роль української художньої підліткової літератури для формування ціннісних орієнтацій  підлітків середнього віку полягає в тому, що художнє слово призводить до великих змін в емоційній сфері читача, сприяє спрямованості його реакцій на різні життєві події, змінює його ставлення до навколишнього світу й самого себе. Завдяки літературним можливостям у процесі читання  підліток відображає у своїй уяві певну картину, конкретну ситуацію, образ, переживає описані події, і чим сильніше його переживання, тим багатше його почуття і уявлення про дійсність. Підліток неначе проникає всередину подій художнього твору, ніби стає їх учасником. Отож, набуваючи живого змісту моральні норми й правила поведінки, наявні у художніх творах, сприймаються й стають ціннісними життєвими орієнтаціями.
Effect of spontaneous fermentation time on physicochemical, nutrient, anti-nutrient and microbiological composition of Lima Bean (Phaseolus lunatus) flour
Authors: Kouadio Patrick N’zi , Kouassi Martial-Didier Adingra , Kouadio Florent N’guessan , Kouadio Constant Attchelouwa , Kablan Tano
Published: June 2022

Objective: Lima bean (Phaseolus lunatus) is a protein-rich legume species, which the consumption causes a problem of digestion due to the high content of anti-nutritional factors. Thus, the objective of this study is to improve the nutritional quality of lima bean by means of fermentation. Methodology and results: The impact of spontaneous fermentation time on lima bean flour proximate composition, antinutrient factors and microbiological composition was evaluated. Lactic acid bacteria counts were the most abundant and their evolution was increased from 0 to 24 hours (3.66 to 10.34 log CFU/mL) and remained stable until 72 hours. A significant increase was observed in yeast and mould counts (2.89 to 6.61 log CFU/mL), while Bacillus counts remained stable. Furthermore, there was a significant reduction (P ˂ 0.05) of anti-nutritional factors such as tannins, phytate and oxalate during fermentation. Finally, lipids, fibres, ash, proteins and sugar content decreased significantly (P˂ 0.05) unlike carbohydrate content. Conclusion and Application of results: Spontaneous fermentation improved the nutritional quality of Lima bean flour. Fermented lima bean flour could be used in the formulation of instant infant meal and animal feed. Keywords: spontaneous fermentation, physicochemical, nutrient, anti-nutrition factors, fermentative microorganisms.
Efektivitas Pelatihan Sistem Surveilans bagi Alumni dengan Metode Online di Masa Pandemi Covid-19
Authors: Pascawati Nur Alvira , Susanto Nugroho , Rosdewi Naomi Nisari , Rusyani Yelli Yani
Published: June 2022

Pandemi COVID-19 memberikan dampak di berbagai sektor khususnya bidang pendidikan dan pelatihan yang saat ini berubah menjadi sistem online. Saat ini kebutuhan pelatihan sistem surveilans bagi para alumni yang bekerja dalam bidang surveilans sangat diperlukan untuk membantu mengendalikan penyebaran Covid-19 melalui penerapan kegiatan 3T (Tracing, Testing dan Treatment). Penelitian ini bertujuan untuk mengukur efektivitas pelatihan sistem surveilans bagi alumni dengan metode online di masa pandemi Covid-19. Penelitian ini menggunakan metode quasi ekperiment dengan desain one group pre test-post test. Sampel dalam penelitian ini adalah 30 alumni peminatan epidemiologi dan penyakit tropis yang berkerja di sektor kesehatan. Analisis data dilakukan dalam 2 tahap yaitu deskriptif dan uji beda (paired sample t-test). Hasil penelitian ini menunjukkan bahwa metode pelatihan online secara signifikan dapat meningkatkan pengetahuan, sikap dan keterampilan para alumni tentang metode surveilans di masa Pandemi Covid-19 dan mereka menyatakan bahwa dapat tetap aktif dalam setiap pembelajaran yang diberikan dan kualitas penugasan dapat membantu meningkatkan pemahaman mereka tentang materi pembelajaran. Beberapa kendala sarana prasarana seperti ketidakstabilan jaringan internet dan konkesi audio dan video cukup mempengaruhi fokus dari peserta.
The Quality Assurance of Medical Record Service Unit in Kariadi Hospital Semarang During Covid-19 Outbreak
Authors: Agiwahyuanto Faik , Astuti Retno , Elisanti Alinea Dwi , Ramadhany Nur Azizha
Published: June 2022

Policies regarding, the flow of medical record service procedures are needed during the COVID-19 pandemic. This pandemic requires medical record unit to adapted quickly. Differences in established patients who were not confirmed by the 2019-nCoV virus. Evaluation of quality assurance medical record service procedures during the COVID-19 pandemic for established patients who are not confirmed by the 2019-nCoV that support person-centered health care is crucial for the officer's needs. This study aims was to know the quality assurance of medical record service unit in Kariadi Hospital Semarang during COVID-19 outbreak. This research conducted from 1 July to 15 August 2020. Research instrument used in-depth interviews sheet and direct with participants used COVID-19 health protocol. Interviews were transcribed verbatim and analysed used Haase's adaptation of Colaizzi's phenomenological. Research data analysis used content analysis with software Atlas.ti. The results, Dr. Kariadi Hospital already has an Standard Operating Procedure (SOP) for the flow of medical record service procedures during the COVID-19 pandemic for new or old patients who are not confirmed by the 2019-nCoV virus. Conclusion that Dr. Kariadi Hospital used quality assurance of electronic medical record to process medical record documents for patients who are not confirmed by the 2019-nCoV.