bluuebunny/crossref_metadata_2025 huggingface dataset:
Tranformasi Digital Madrasah Untuk Peningkatan Mutu Layanan Pendidikan Di Mts Al Kaustar Kota Depok
Authors: Hariyadi Hariyadi
Published: May 2023

Indonesia telah memasuki era digital 4.0 dan sudah seharusnya era digital tidak hanya dijadikan jargon semata. Hal terpenting pada saat ini adalah adaptasi terhadap transformasi dan segala bentuk yang berkaitan dengan digitalisasi Teknologi Informasi. Masalah yang terjadi saat ini adalah lemahnya kemauan dan kemampuan sumber daya manusia (SDM) dalam menghadapi era digital ini. Penelitian ini bertujuan untuk mengetahui tantangan dan solusi dalam menghadapi transformasi Digital untuk peningkatan mutu layanan pendidikan di MTs Al Kautsar Kota Depok, adapun metode penelitian ini dengan menggunakan metode kombinasi (mixed methods), model tindakan (action research), serta penelitian dan pengembangan (Research and Development). Dari riset ini beberapa hal menjadi saran prioritas kepada lembaga untuk terus konsisten menghadapi era digital di antaranya sumber daya manusia (SDM) harus memiliki kualifikasi dan kompetensi yang baik, memiliki ketangkasan, inovasi, antisipasi, kreativitas, eksperimen, keterbukaan pikiran dan jaringan yang luas sehingga tranformasi digital madrasah untuk peningkatan mutu layanan dapat terlaksana dengan efektif dan efisien.
Sentimen Analisis Tradisi Kawin Tangkap Di Daerah Sumba Menggunakan Metode SVM
Authors: Para Udayani , Hariadi Fajar , Talakua Alfrian C.
Published: May 2023

Twitter merupakan salah satu media sosial yang populer di dunia. Indonesia merupakan negara pengguna Twitter terbanyak ke 5 di dunia. Melalui Twitter, pengguna bisa berbagi keseharian, membagikan foto, ataupun menyampaikan opini mengenai suatu hal. Biasanya, topik yang sedang menjadi perbincangan hangat di Twitter akan menjadi trending topic. Suku Sumba sendiri masih menganut sistem kekeluargaan patrilineal yang kental dengan berbagai ragam adat dan tradisi yang masih dipertahankan hingga masa kini, salah satunya adalah tradisi kawin tangkap dimana perkawinan tersebut terjadi atas dasar paksaan salah satu pihak. Menurut sebagian besar orang, tradisi kawin tangkap Suku Sumba ini merupakan pemaksaan perkawinan yang mengakibatkan terjadinya tindakan kekerasan seksual dimana korban mengalami kerugian fisik dan mental. Namun menurut tetua adat sekitar, tradisi kawin tangkap ini dianggap sebagai suatu perkawinan adat yang sah di dalam masyarakat dan harus terus dilestarikan dalam kehidupan masyarakat sekitar. Penelitian ini akan melakukan analisis tentang bagaimana tanggapan masyarakat Indonesia terhadap tradisi kawin tangkap yang terjadi di daerah Sumba melalui Twitter. Data yang akan dianalisis adalah tweets tentang tradisi kawin tangkap dari Agustus 2019 hingga Agustus 2022. Data tersebut kemudian akan diklasifikasi menjadi tiga kelas sentimen, yakni Negatif, Netral dan Positif. Dan akan Menggunakan Metode Support Vector Machine. Kemudian berdasarkan dari total 1394 data tweet tentang Kawin Tangkap didaerah Sumba dan telah dilakukan pemrosesan menggunakan SVM pada 418 data sehingga menghasilkan jumlah data berlabel negatif 175, berlabel netral 82 dan berlabel positif 161. Sehingga dapat disimpulkan bahwa opini masyarakat terkait kawin tangkap yang terjadi di daerah Sumba lebih cenderung bersentimen Negatif.
Implementasi OOP dalam Digital Marketing Rumah Kaktus Bandung
Authors: Suprayogi Bambang , Lesmana Budi , Novita Dien , Sumarni Teti
Published: May 2023

Website Rumah Kaktus Bandung Jawa Barat merupakan website yang dibangun dengan menggunakan framework bootstrap, PHP dan MySql dengan menu Beranda yang berisikan informasi sekitar informasi tentang kaktus, Tentang Kami informasi tentang Rumah Kaktus Bandung, Blog Kami tentang Informasi informasi sejarah rumah kaktus bandung dan Kontak berisikan informasi alamat dan no telepon Rumah Kaktus Bandung. Dalam penerapan framework bootstrap, PHP dengan database MySQL sebagai penampung data-data seperti data jenis tanaman kaktus agar bisa lebih dinamis dalam pengelolaan data Rumah Kaktus Bandung tersebut. Data tersebut dapat dipergunakan untuk sarana promosi sebagai salah satu implementasi digital marketing  rumah kaktus bandung dalam meningkatkan penjualan kaktus dengan pemanfaatan Object Oriented Programming dan sebagai penyampaian informasi berbagai jenis kaktus yang ada di rumah kaktus bandung kepada semua pihak baik secara online atau offline kepada masyarakat dengan cepat dan efisien
ANALISIS FAKTOR-FAKTOR KEBERHASILAN SISTEM E-LEARNING MENGGUNAKAN MODEL DELONE DAN MCLEAN
Authors: Raharja Dwi Risza Budi , Rokanta Siswono Akuan
Published: May 2023

Jaman semakin berkembang dan teknologi juga mengalami perubahan yang sangat pesat, banyak sekali hal-hal baru yang tercipta dan digunakan untuk menunjang aktivitas sehari-hari. Misalnya yang sedang berkembang saat ini terkait dengan penggunaan teknologi real time. Dimana kita akan dapat berkomunikasi secara langsung tanpa harus mengadakan pertemuan dalam artian dapat dilakukan di kota atau pulau yang berbeda. Dari perkembangan tersebut, terciptalah sebuah e-learning yang membantu pelaksanaan proses pembelajaran secara online, baik itu mengunduh materi, mengumpulkan tugas, hingga melakukan komunikasi dua arah antara dosen dengan mahasiswa atau mahasiswa dengan mahasiswa melalui sebuah forum. Dalam kondisi pandemi Covid-19 yang sudah masuk ke Indonesia, memaksa Anda untuk melakukan semua aktivitas di rumah dan ini akan menguji kualitas sistem E-Learning yang terdapat di universitas X. Dampak dari pandemi tersebut telah membuat keputusan bahwa Kuliah hybrid akan dilakukan. dengan konsep perkuliahan dilakukan secara dua arah. Dari metode tersebut timbul permasalahan karena penerapan metode kuliah hybrid merupakan hal yang baru, sehingga timbul pertanyaan, apakah metode perkuliahan sudah berhasil diterapkan dan mahasiswa menerima penerapan sistem tersebut
Peningkatan Keamanan Sistem Informasi Nilai Dengan Notifikasi Whatsapp Di Prodi Teknik Informatika Universitas Pelita Bangsa
Authors: Firmansyah Andri
Published: May 2023

Perkembangan teknologi telah mengalami kemajuan yang pesat dalam beberapa dekade terakhir. Dalam bidang teknologi informasi, terdapat penemuan dan pengembangan komputer, internet, smartphone, dan aplikasi digital yang terus meningkatkan koneksi, akses, dan produktivitas manusia. Program studi Teknik Informatika umumnya memiliki sistem informasi nilai yang memudahkan mahasiswa untuk memantau kemajuan akademik mereka. Sistem informasi ini memungkinkan mahasiswa untuk mengakses informasi nilai secara cepat, akurat, dan efisien. Namun, seperti halnya dengan teknologi lainnya, ada kemungkinan bahwa sistem informasi nilai untuk mahasiswa masih memiliki celah keamanan yang perlu diatasi. Hasil penelitian menunjukkan bahwa pengguna sistem informasi nilai ini merasa lebih tenang karena mereka dapat mengetahui aktivitas login yang terjadi pada akun WhatsApp mereka. Selain itu, pengguna juga dapat menerima notifikasi secara instan melalui pesan WhatsApp jika terdapat aktivitas login mencurigakan atau dilakukan dari perangkat yang tidak dikenal.
High Availability Moodle dengan Load Balancer pada Three-tier Architecture
Authors: Ismail Ade
Published: May 2023

LMS Moodle merupakan salah satu platform e-learning yang populer dan banyak digunakan oleh institusi pendidikan. Namun, keberhasilan penggunaan platform ini sangat tergantung pada performansi dan kehandalan sistem. Oleh karena itu, pengujian performansi Moodle pada arsitektur three tier menggunakan JMeter menjadi topik yang diminati dalam beberapa penelitian. Pada penelitian ini, dilakukan pengujian performansi Moodle dengan variabel yang dinilai meliputi response time, error rate, concurrency, dan availability pada arsitektur three tier dengan tambahan unsur load balancing menggunakan JMeter. Pengujian dilakukan dengan jumlah user yang bervariasi dan waktu yang berbeda, dengan tujuan untuk mengevaluasi performansi Moodle dalam kondisi yang berbeda. Selain itu, dilakukan juga pembandingan antara hasil pengujian pada arsitektur three tier dengan arsitektur single tier. Hasil pengujian menunjukkan bahwa arsitektur three tier dengan tambahan unsur load balancing memiliki performansi yang lebih baik daripada arsitektur single tier, dengan nilai rata-rata response time yang lebih rendah, error rate yang lebih kecil, nilai concurrency yang lebih tinggi, dan nilai availability yang lebih stabil pada waktu yang berbeda. Hal ini menunjukkan bahwa penggunaan arsitektur three tier dengan tambahan unsur load balancing dapat meningkatkan performansi platform e-learning Moodle.
Purwarupa Aplikasi Android Jual Beli Ikan Hias Online
Authors: Khaeruzzaman Yaman , Arrosyid Firman
Published: May 2023

Transaksi jual beli online semakin meningkat terutama untuk jenis barang atau benda mati. Hal ini dikarenakan sarana penunjang logistic pengiriman tidak ada kendala kebijakan pengiriman.  Berbeda dengan jual beli mahluk hidup seperti ikan hias yang membutuhkan penanganan proses logistik yang khusus seperti penyediaan media air beroksigen di dalam bungkus yang tidak boleh bocor dan membutuhkan waktu pengiriman yang singkat untuk menjaga agar ikan hias tersebut tetap hidup dan sehat.   Permasalah lain yang dihadapi yaitu sulitnya memahami penjelasan lokasi penjual, lamanya proses pengiriman, ikan hias tidak sesuai dengan gambar dan deskripsinya, harga ikan tidak transparan dan dicantumkan, serta penjual atau pembeli sulit dihubungi. Oleh sebab itu kebutuhan pengembangan aplikasi android jual beli ikan hias online muncul pada komunitas penggemar ikan hias Mega Mendung Betta Cirebon, dengan tujuan membangun sistem yang dapat menghubungkan penjual dan pembeli, dan memfasilitasi kemudahan proses jual beli seperti memberikan lokasi penjual dan pembeli yang lebih akurat dan estimasi waktu pengiriman dari tempat penjual ke tempat pembeli,  serta membantu mempromosikan produk ikan hiasnya lebih luas.  Penelitian ini menggunakan metode analisis deskriptif dan metode pengembangan sistem prototipe. Sumber data yang digunakan adalah data primer sekunder, didapat dari hasil observasi, wawancara dan studi pustaka.  Implementasi aplikasi menggunakan bahasa pemrograman PHP dan Java, serta menggunakan MySQL sebagai pengolah database. Perancangan sistem dimodelkan dengan menggunakan Data Flow Diagram (DFD) dan Entity Relationship Diagram (ERD).  Purwarupa aplikasi android jual beli ikan hias online berhasil dibuat dan diuji menggunakan blackbox testing dengan hasil 23 dari 24 butir pengujian atau 95,83 % telah berhasil dan sesuai dengan yang diharapakan.
Virtual Museum Lukis Berbasis WebGl Untuk Meningkatkan Pengetahuan Seni Lukis
Authors: Damayanti Retno , Wibowo Dimas Wahyu , Muslik Ahmad Kofi Anan Farizqi
Published: May 2023

Perkembangan teknologi yang terus berkembang secara tidak langsung mempunyai dampak positif dan negatif, salah satunya yaitu kurangnya kesadaran dalam mengetahui peninggalan sejarah. Salah satunya adalah sebuah karya seni lukis yang mempunyai cerita atau sejarah masing-masing. Oleh karena itu untuk tetap mempertahankan serta meningkatkan pengetahuan mengenai karya seni lukis dapat dengan memanfaatkan perkembangan teknologi yaitu sebuah Virtual Museum Lukis. Virtual Museum Lukis yang dikembangkan berbasis WebGL dengan menggunakan Three Js yang merupakan library javascript khusus untuk mengolah objek secara 3D sehingga user dapat mengakses melalui browser pc masing-masing. Dengan teknologi tersebut memungkinkan pengguna dapat merasakan seolah-olah berada didalam museum, dan dapat berkeliling serta berinteraksi dengan koleksi museum dengan cara menekan tombol yang sudah disediakan. Dalam melakukan pengembangan Virtual Museum Lukis, terdapat sebuah metode yang dapat membantu dan dapat mempermudah dalam proses pembuatan yaitu menggunakan Multimedia Development Life Cycle. Sehingga menghasilkan nilai usability sebesar 87,4%, nilai fungsionalitas sebesar 85,7% dan nilai uji keefektifan Virtual Museum Lukis untuk meningkatkan minat dan pengetahuan seni lukis sebesar 71,6% yang didapatkan dari pengujian dengan user sebanyak 30 responden.
PENCEGAHAN DEMAM BERDARAH PADA LINGKUNGAN SEKOLAH TAMBOSUPA MELALUI PERILAKU HIDUP BERSIH-SEHAT
Authors: Indalifiany Astrid , Sabarudin Sabarudin , Halik Halik , Hikmah Nurull , Nggawu La Ode , Nirmala Fifi
Published: May 2023

Dengue fever is an infectious disease spread by the bite of the Aedes mosquito, especially Aedes aegypti. The fact that the Aedes aegypti mosquito often bites during the day during school activities, makes schools a potential location for the spread of DHF. To stop the spread of dengue fever, clean and healthy living behavior (PHBS) can be implemented by washing hands properly, keeping classrooms clean, eating healthy food, exercising regularly, and getting enough sleep. Other efforts are wearing a mask when in crowds, maintaining a safe distance, and using 3M-plus to prevent dengue, such as draining, covering, and burying. The purpose of this service is to educate junior high school students in Tambosupa Konawe Selatan Village about maintaining a clean school environment and avoiding various diseases, especially DHF, to increase their knowledge and skills regarding clean and healthy behavior (PHBS).
PENYULUHAN TEKNIK PERBANYAKAN DAN PENGEMASAN LEBAH MADU (TRIGONA SP.) DI KECAMATAN BARUGA, KOTA KENDARI
Authors: Rianse Ilma Sarimustaqiyma , Sadimantara Fahria Nadiryati , Baka Wa Kuasa , Kolewora Yusuf Musafir , Kusumabaka Rianse Muhammad Iqbal , Kasman Arifin Ida Mardhiah Afrini
Published: May 2023

Program Kemitraan Masyarakat Fakultas Pertanian Universistas Halu Oleo Kendari dengan salah satu mitra Kelompok Tani Mataiwoi Kecamatan Baruga Kota Kendari telah melaksanakan pengabdian kepada masyarakat dengan tujuan memberikan dorongan, spirit kepada kelompok tani hortikultura dan tanaman perkebunan dalam meningkatkan usaha lebah madu Trigona sp. dalam meningkatkan produktifitasnya. Pelaksaaan Program Kemitraan Masyarakat (PKM) menjadi sangat tepat sebagai sarana dan media transfer teknologi untuk meningkatkan produktivitas Kelompok Tani. Metode Pelaksanaan Kegiatan PKM dilaksanakan atas dasar hasil observasi dan permasalahan yang di temukan di lapangan.Target luaran yang dicapai dari pelaksanaan program ini adalah: (1) Mitra tani menguasai teknik perbanyakan dan pemindahan koloni Trigona sp.,yang berdasarkan kaidah ekologinya (2) Mitra tani mengetahui ada cara pembuatan stup yang di senangi oleh lebah madu Trigonasp., (3) Mitra tani dapat mengenal cara pemanenan madu Trigonasp., yang baik dan higenis (4) Mitra tani dapat mengemas madu yang layak jual dengan standarisasi instansi terkait sehingga produk madu yang dihasilkan lebih diterima oleh konsumen karena tingkat kesadaran konsumen tentang produk yang lebih aman semakin baik
Effect of thermomechanical aging on the surface roughness and color stability of novel CAD-CAM materials: An in-vitro study
Authors: DİKEN TÜRKSAYAR Almira Ada , DÖNMEZ Mustafa Borga , HİSARBEYLİ Duygu , SEÇKİN KELTEN Özlem
Published: May 2023

Objective:. This in-vitro study aimed to evaluate the surface roughness (Ra) and color stability of novel monolithic CAD-CAM materials after thermomechanical aging.

Methods: Forty specimens were obtained from 4 different materials (a resilient ceramic (C), ceramic-reinforced PEEK (BH), lithium disilicate glass ceramic (EX), and a resin based composites (B) (n=10). Initial Ra and color coordinates were recorded. All specimens were than subjected to thermomechanical aging. Ra and color coordinate measurements were repeated. CIEDE2000 formula was used to calculate the color changes (ΔE00). Kruskal-Wallis and Dunn tests were used to analyze data, while the effect of aging on Ra was analyzed with Wilcoxon test (α=.05).

Results: Regardless of aging, BH showed higher Ra than EX (P.05). Ra of ceramic-reinforced PEEK was above clinical threshold, regardless of thermomechanical aging.

Conclusion: Thermomechanical aging caused a color change that was perceptible for all the materials tested, while it was also unacceptable for ceramic-reinforced PEEK.
Validity and Reliability of the Turkish Version of the Postoperative Fatigue Scale
Authors: ÇETİNKAYA Funda , ÜNAL ASLAN Kevser Sevgi
Published: May 2023

Objective: Postoperative fatigue is an undesired and discouraging symptom that many patients experience after the surgery operation. Good assessment is essential to detect and manage this symptom. There is no specific Turkish validity and reliability measurement tool to assess postoperative fatigue. In this study, it was conducted to adapt the Postoperative Fatigue Scale (PO-FS) to Turkish in order to evaluate postoperative fatigue.

Methods: Methodological study method was applied. This study was conducted with a total of 276 patients. The data of the study were collected using the personal information form, PO-FS and Visual Analog Scale-Fatigue in April-July 2019.

Results: PO-FS sub-scales fatigue, vigor, and daily life activities have Cronbach’s α coefficient of 0.873, 0.898, and 0.815, respectively. The factorial analysis revealed that three factors explain 76.344% of the total variance. These findings suggest that Turkish version of PO-FS is a valid and reliable scale.

Conclusion: PO-FS’s Turkish translation is valid and can be reliably used for determining the postoperative fatigue of patients.
Evaluation of Residual Root Canal Sealer Removal Efficacy of Different Irrigation Activation Techniques by Confocal Laser Microscopy Analysis
Authors: UĞUR AYDIN Zeliha , ALTUNBAŞ Demet , KOŞUMCU Sevim , MEŞECİ Büşra , DOĞAN Tülin
Published: May 2023

Objective: The purpose of this study was to use confocal laser microscopy analysis to evaluate the effectiveness of conventional needle irrigation (CNI), EndoActivator (EA), and EDDY during endodontic retreatment.

Methods: This study included 45 maxillary incisor teeth with a single root and canal. Root canals were prepared with ProTaper Universal files (Dentsply Sirona, Ballaigues, Switzerland) and obturated with labeled sealer mixed with 0.1% Rhodamine B and gutta percha according to single cone techniques. Initial root canal filling material was removed using ProTaper Universal Retreatment files and F4 files. Teeth randomly were divided into 3 groups (n = 15) depending on the activation technique: CNI, EA (Dentsply, Tulsa Dental Specialties, Tulsa, OK), and EDDY (VDW, Munich, Germany). Confocal laser microscopy was used to evaluate the penetration area, depth, and percentage of the residual sealer in the apical, middle, and coronal sections after irrigation activation.

Results: In all sections, the EDDY group had a lower penetration area of residual sealer than the CNI group (P< .05). In comparison to the coronal section, the penetration percentage of the CNI and EA groups was lower in the apical section (P< .05). In the CNI group, the penetration depth was higher at the coronal section than at the apical and middle sections (P< .05), and it was higher at the coronal section than at the apical section.

Conclusion: Within the limitations of this study, none of the activation systems tested could completely remove the residual sealer. However, the lowest residual sealer was seen after using EA and EDDY.
Проект Федерального закона «О патриотическом воспитании в Российской Федерации» – основа всей системы отношений и деятельности в этой сфере
Authors: Лутовинов Владимир Ильич
Published: May 2023

В настоящее время по-прежнему отсутствует системная и целенаправленная работа с молодёжью, в том числе с использованием программно-целевых методов. Все более неотложным является решение задачи фундаментального и всеобъемлющего рассмотрения комплекса проблем, накопившихся в сфере патриотического воспитания как важнейшего компонента воспитания в целом. Их решение невозможно без создания принципиально новой нормативной правовой базы, основанной на глубоком и всестороннем анализе происходящих в российском обществе изменений, тенденций развития, новых подходов к созданию качественно иных основ патриотической работы с подрастающим поколением, учитывающих систему его ценностей, потребностей и интересов. Очевидны необходимость и неотложность разработки и принятия федерального закона «О патриотическом воспитании в РФ».
At present, there is still no systematic and purposeful work with young people, including the use of program-targeted methods. More and more urgent is the solution of the problem of fundamental and comprehensive consideration of the complex of problems that have accumulated in the field of patriotic education as the most important component of education as a whole. Their solution is impossible without the creation of a fundamentally new regulatory framework based on a deep and comprehensive analysis of the changes taking place in Russian society, development trends, new approaches to creating qualitatively different foundations for patriotic work with the younger generation, taking into account the system of its values, needs and interests. The necessity and urgency of the development and adoption of the federal law «On Patriotic Education in the Russian Federation» is obvious.
Русский патриотизм как историческое явление
Authors: Кириченко Олег Викторович
Published: May 2023

Статья посвящена актуальной сегодня теме «русского патриотизма» как исторического явления, не имеющего отношения к националистической злободневности, вытекающего из сформировавшейся за многие века этнической ментальности, этнической культуры, этнической традиции русского народа. Автор показывает, что русский патриотизм как «чувство, вера и знание», реализуемое по отношению к государству, прошел долгую, многовековую школу освоения высоких смыслов, выраженных в понятиях «Русская земля», «Святая Русь», «Москва – Третий Рим», и в этом качестве может рассматриваться как составная часть устоявшегося русского этнотипа, с его конкретными этническими границами и константами. Мы показываем, что Российское государство, заинтересованное в скором и эффективном решении чисто государственных проблем, с начала XVIII в. проводит новую политику формирования патриотизма – отдельно государственную и народную. Прозападный официальный курс трансформировался за прошедшие триста лет, но сохраняется до сегодняшнего дня. Противоречие, заложенное в основу этой модели, до сих пор оказывает негативное влияние на эффективность патриотического воспитания в стране, в том числе и на русский патриотизм.

The article is devoted to the current topic of «Russian patriotism» as a historical phenomenon that has nothing to do with nationalist topicality, arising from the ethnic mentality, ethnic culture, ethnic tradition of the Russian people that has been formed over many centuries. The author shows that Russian patriotism as a «feeling and knowledge», implemented in relation to the state, has gone through a long, centuries-old school of mastering high meanings, expressed in the concepts of «Russian land», «Holy Russia», «Moscow – the Third Rome», and this as an integral part of the established Russian ethnotype, with its specific ethnic boundaries and constants. We show that the Russian state, interested in the speedy and effective solution of purely state problems, from the beginning of the 18th century. pursues a new policy of formation of patriotism – separately state and folk patriotism. The pro-Western official course has been modified over the past three hundred years, but remains to this day. The contradiction underlying this model still has a negative impact on the effectiveness of patriotic education in the country, including Russian patriotism.
О связи исторического и мистического измерений (чудесах) в жизни Церкви на примере некоторых сказаний XVI–XVII веков
Authors: Лихачев Алексий
Published: May 2023

Автор как богослов и служащий священник в кратком системном обзоре выражает главную интуицию религиозного сознания о взаимосвязи материального и духовного миров. Эта связь – характерная черта «персоналистического дуализма» (всех авраамических религий), но постулируется богословской категорией «энергии» как ключевым понятием православного мировоззрения. Через анализ некоторых сказаний (в том числе «Сказания о Сошествии Иисусова Креста на Сахотском болоте», конец XVII в.) показываются примеры восприятия чудесных явлений, делается попытка раскрыть богатство объяснительного принципа Диалога, когда само бытие человека воспринимается как общение Творца и Его разумного творения. Предупреждается об опасности ложного мистицизма, преодолеваемой принципами трезвения и презумпции естественности.
The author, as a theologian and serving priest, in a brief systematic review expresses the main intuition of religious consciousness about the relationship between the material and spiritual worlds. This connection is a characteristic feature of «personalistic dualism» (of all Abrahamic religions), but is postulated by the theological category of «energy» as a key concept of the Orthodox worldview. Through the analysis of some legends (including the «Tale of the Descent of the Jesus Cross on the Sakhot Swamp», the end of the 17th century), examples of the perception of miraculous phenomena are shown, an attempt is made to reveal the richness of the explanatory prin ciple of Dialogue, when the very existence of a person is perceived as a communication between the Creator and His rational creation. It is warned about the danger of false mysticism, overcome by the principles of sobriety and the presumption of naturalness.
Письма к протоиерею Михаилу Труханову. Часть 1: Письма доктора П. К. Лукошевичуса
Authors: Шляхтина Наталья Валерьевна
Published: May 2023

Публикацией писем к протоиерею Михаилу Труханову мы начинаем новый этап работы с эпистолярным наследием этого богослова, духовного писателя и мыслителя. Мы представляем тексты, аккумулирующие в себе важные события или размышления, которые относятся к общим вопросам религиозной жизни этой эпохи. В лице о. Михаила люди искали духовника-старца и эксперта по самым важным духовным вопросам. В этом эпистолярном наследии мы находим следы церковной жизни 1970– 1990-х годов, характеристики людей и судеб, соприкоснувшихся в лице о. Михаила с неким идеалом веры и подлинной религиозности. В настоящем номере публикуются письма Петраса Казимировича Лукошевичуса, врача, близкого отцу Михаилу по совместному пребыванию в лагере. Перед нами предстает «торжество православия» – лагерный опыт духовности о. Михаила, признаваемый его друзьями–иноверцами и иноплеменниками. Ему П. К. Лукошевичус доверяет молиться за свой народ, хотя при этом критично относится и к «царской», и к советской власти. Публикация писем других корреспондентов к протоиерею Михаилу предполагается в нескольких номерах журнала.
By publishing letters to Archpriest Mikhail Trukhanov, we begin a new stage of work with the epistolary heritage of this theologian, spiritual writer and thinker. We present texts that accumulate important events or reflections that relate to the general issues of the religious life of this era. In the face of Michael, people were looking for an elder confessor and an expert on the most important spiritual issues. In this epistolary heritage, we find traces of church life in the 1970s–1990s, the characteristics of people and destinies that came into contact with a certain ideal of faith and true religiosity displayed by of Fr. Mikhail. This issue contains letters from Petras Kazimirovich Lukosevicius, a pediatrician who was close to Father Mikhail during their joint incarceration in the camp. Before us appears the «triumph of Orthodoxy» – the camp experience of spirituality Fr. Michael, recognized by his friends – infidels and foreigners. P. K. Lukoshevichus trusts him to pray for his people, although at the same time he is critical of both the «tsarist» and the Soviet authorities. The publication of letters from other correspondents to Archpriest Michael is expected in several issues of the journal.
Clinico-cytopathological subcategorization in thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance using the TIRADS and Bethesda classifications
Authors: Babajani Amirhesam , Rahmani Saeed , Raoufi Masoomeh , Eidgahi Elham Shaarbaf , Dastjerdi Amirreza Vahid , Behfarnia Poya , Khalili Shayesteh , Moghaddam Noushin Afshar
Published: May 2023

Introduction

Bethesda category III – atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) is a heterogeneous class of the Bethesda system for thyroid nodules. In order to clarify the therapeutic road for clinicians, this category was subclassified based on the cytopathological features. In this study, we evaluated the risk of malignancy, surgical outcome, demographic characteristics, and correlation of ultrasound features with the final outcome in patients with thyroid nodules based on AUS/FLUS subclassification.

Method

After evaluating 867 thyroid nodules from three different centers, 70 (8.07%) were initially diagnosed as AUS/FLUS. The cytopathologists re-interpreted the FNA samples and subclassified them into five subcategories: architectural atypia, cytologic atypia, cytologic and architectural atypia, and Hürthle cell AUS/FLUS, and atypia, which was not specified. Based on the suspicious ultrasound features, an appropriate ACR TI-RADS score was allocated to each nodule. Finally, the malignancy rate, surgical outcomes, and ACR TI-RADS scores were evaluated among Bethesda category III nodules.

Results

Among the 70 evaluated nodules, 28 (40%) were subclassified as Hürthle cell AUS/FLUS, 22 (31.42%) as cytologic and architectural atypia, 8 (11.42%) as architectural atypia, 7 (10%) as cytologic atypia, and 5 (7.14%) as atypia which was not specified. The overall malignancy rate was 34.28%, and the architectural atypia and Hürthle cell nodules displayed lower malignancy compared to other groups (P-Value<0.05). Utilizing ACR TI-RADS scores showed no statistical significance between Bethesda III subcategorization and ACR TI-RADS scores. However, ACR TI-RADS can be a reliable predictor for Hürthle cell AUS/FLU nodules.

Conclusion

ACR TI-RADS helps evaluate malignancy only in the Hürthle cell AUS/FLUS subcategory of AUS/FLUS. Besides, cytopathological reporting based on the suggested AUS/FLUS subclassification could help clinicians take appropriate measures to manage thyroid nodules.
Signaling metabolite β-aminoisobutyric acid as a metabolic regulator, biomarker, and potential exercise pill
Authors: Yi Xuejie , Yang Yang , Li Tao , Li Menghuan , Yao Tingting , Hu Guangxuan , Wan Genmeng , Chang Bo
Published: May 2023

Signaling metabolites can effectively regulate the biological functions of many tissues and organs. β-Aminoisobutyric acid (BAIBA), a product of valine and thymine catabolism in skeletal muscle, has been reported to participate in the regulation of lipid, glucose, and bone metabolism, as well as in inflammation and oxidative stress. BAIBA is produced during exercise and is involved in the exercise response. No side effect has been observed in human and rat studies, suggesting that BAIBA can be developed as a pill that confers the benefits of exercise to subjects who, for some reason, are unable to do so. Further, BAIBA has been confirmed to participate in the diagnosis and prevention of diseases as an important biological marker of disease. The current review aimed to discuss the roles of BAIBA in multiple physiological processes and the possible pathways of its action, and assess the progress toward the development of BAIBA as an exercise mimic and biomarker with relevance to multiple disease states, in order to provide new ideas and strategies for basic research and disease prevention in related fields.
Arabidopsis histone deacetylase HD2A and HD2B regulate seed dormancy by repressing DELAY OF GERMINATION 1
Authors: Han Yongtao , Georgii Elisabeth , Priego-Cubero Santiago , Wurm Christoph J. , Hüther Patrick , Huber Gregor , Koller Robert , Becker Claude , Durner Jörg , Lindermayr Christian
Published: May 2023

Seed dormancy is a crucial developmental transition that affects the adaption and survival of plants. Arabidopsis DELAY OF GERMINATION 1 (DOG1) is known as a master regulator of seed dormancy. However, although several upstream factors of DOG1 have been reported, the exact regulation of DOG1 is not fully understood. Histone acetylation is an important regulatory layer, controlled by histone acetyltransferases and histone deacetylases. Histone acetylation strongly correlates with transcriptionally active chromatin, whereas heterochromatin is generally characterized by hypoacetylated histones. Here we describe that loss of function of two plant-specific histone deacetylases, HD2A and HD2B, resulted in enhanced seed dormancy in Arabidopsis. Interestingly, the silencing of HD2A and HD2B caused hyperacetylation of the DOG1 locus and promoted the expression of DOG1 during seed maturation and imbibition. Knockout of DOG1 could rescue the seed dormancy and partly rescue the disturbed development phenotype of hd2ahd2b. Transcriptomic analysis of the hd2ahd2b line shows that many genes involved in seed development were impaired. Moreover, we demonstrated that HSI2 and HSL1 interact with HD2A and HD2B. In sum, these results suggest that HSI2 and HSL1 might recruit HD2A and HD2B to DOG1 to negatively regulate DOG1 expression and to reduce seed dormancy, consequently, affecting seed development during seed maturation and promoting seed germination during imbibition.
Accurate prediction of huanglongbing occurrence in citrus plants by machine learning-based analysis of symbiotic bacteria
Authors: Liu Hao-Qiang , Zhao Ze-long , Li Hong-Jun , Yu Shi-Jiang , Cong Lin , Ding Li-Li , Ran Chun , Wang Xue-Feng
Published: May 2023

Huanglongbing (HLB), the most prevalent citrus disease worldwide, is responsible for substantial yield and economic losses. Phytobiomes, which have critical effects on plant health, are associated with HLB outcomes. The development of a refined model for predicting HLB outbreaks based on phytobiome markers may facilitate early disease detection, thus enabling growers to minimize damages. Although some investigations have focused on differences in the phytobiomes of HLB-infected citrus plants and healthy ones, individual studies are inappropriate for generating common biomarkers useful for detecting HLB on a global scale. In this study, we therefore obtained bacterial information from several independent datasets representing hundreds of citrus samples from six continents and used these data to construct HLB prediction models based on 10 machine learning algorithms. We detected clear differences in the phyllosphere and rhizosphere microbiomes of HLB-infected and healthy citrus samples. Moreover, phytobiome alpha diversity indices were consistently higher for healthy samples. Furthermore, the contribution of stochastic processes to citrus rhizosphere and phyllosphere microbiome assemblies decreased in response to HLB. Comparison of all constructed models indicated that a random forest model based on 28 bacterial genera in the rhizosphere and a bagging model based on 17 bacterial species in the phyllosphere predicted the health status of citrus plants with almost 100% accuracy. Our results thus demonstrate that machine learning models and phytobiome biomarkers may be applied to evaluate the health status of citrus plants.
Optimising Airport Ground Resource Allocation for Multiple Aircraft Using Machine Learning-Based Arrival Time Prediction
Authors: Sahadevan Deepudev , Al Ali Hannah , Notman Dorian , Mukandavire Zindoga
Published: May 2023

Managing aircraft turnaround is a complex process due to various factors, including passenger handling. Airport ground handling, resource planning, optimal manpower, and equipment utilisation are some cost-cutting strategies, particularly for airlines and ground handling service teams. Scheduled aircraft arrival and departure times are critical aspects of the entire ground management and passenger handling process. This research aimed to optimise airport ground resource allocation for multiple aircraft using machine learning-based prediction methodologies to enhance the prediction of aircraft arrival time, an uncontrollable variable. Our proposed models include a multiple linear regression (MLR) model and a multilayer perceptron (MLP)-based model, both of which are used for predicting round-trip arrival times. Additionally, we developed a MLP-based model for multiclass classification of arrival delays based on departure time and delay from the same airport. Under normal weather conditions and operational scenarios, the models were able to predict round-trip arrival times with a root mean squared error of 8 min for each origin–destination pair and classify arrival delays with an average accuracy of 93.5%. Our findings suggest that machine learning-based approaches can be used to predict round-trip arrival times based on the departure time from the same airport, and thereby accurately estimate the number of actual flight movements per hour well in advance. This predictability enables optimised ground resource planning for multiple aircraft based on constrained airport resource deployment and utilisation.
Estimating Freezing Injury on Olive Trees: A Comparative Study of Computing Models Based on Electrolyte Leakage and Tetrazolium Tests
Authors: Rezaei Mehdi , Rohani Abbas
Published: May 2023

Winter frost injury is a major limiting factor for olive cultivation in temperate regions. The response of olive shoots to freezing stress can be used for selecting genotypes resistant to freezing. The electrolyte leakage (EL) and tetrazolium tests (TZ) are commonly used to evaluate dead tissues in cold stress studies. The temperature–response curve of dead tissues to lethal temperature (LT) is measured with models to calculate LT50 and LT90. In this study, we evaluated the accuracy and efficiency of eighteen nonlinear regression models (NLRs) in calculating LT50 and LT90 of freezing stress in different olive cultivars at various stages of dormancy. After evaluating the prediction performance of NLR models, it was found that only eight models were suitable for the purpose of this research out of the eighteen models examined. The 2p-logistic and Gompertz models were selected for modeling EL and TZ, respectively. Our research findings indicate that the Roughani, Kawi, and Zard varieties of olive trees exhibit the best performance under artificial temperature-controlled conditions. Our findings provide valuable insights into selecting frost-resistant cultivars and designing effective strategies for cold acclimation in olive cultivation.
Nematicidal Effects of Four Terpenes Differ among Entomopathogenic Nematode Species
Authors: Kotsinis Vasileios , Dritsoulas Alexandros , Ntinokas Dionysios , Giannakou Ioannis O.
Published: May 2023

Entomopathogenic nematodes (EPNs) have been studied for more than half a century, and employed for insect pest management using augmentation, conservation, and classical biological control approaches. As obligate lethal parasitoids of insect larvae, EPN navigate a chemically complex soil environment and interact with their insect hosts, plants, and each other. EPN responses to various terpenes, such as herbivore-induced plant volatiles, have the potential to enhance EPN efficacy through their attraction. However, several of the terpenes are currently being formulated as biological fungicides, insecticides, and acaricides for above- or below-ground applications. We conducted laboratory experiments to investigate the possible nematicidal effect of four terpenes, carvacrol, geraniol, eugenol, and thymol, to two heterorhabditids and two steinernematid species. Each terpene showed nematicidal activity against at least two of the four EPN species, with carvacrol showing the strongest activity and Heterorhabditis bacteriophora the highest sensitivity. Despite the high sensitivity of both heterorhabditids and near-zero sensitivity of the steinernematids to thymol, carvacrol, and eugenol, an increasing effect was observed when steinermatid nematodes were exposed to geraniol, and a decreasing effect for heterorhabditids, with H. bacteriophora exhibiting higher mortality than H. indica. The virulence of the nematodes towards fourth instar Galleria mellonella was also tested after exposure to the median lethal doses of each terpene. No significant difference in virulence was observed between nematodes that were exposed or not exposed to sublethal doses. The experiments suggest that the tested terpenes have a strong effect on EPN viability, which should be considered when combining the two approaches in IPM. The terpenes did not have a universal effect on all nematode species, which merits further investigation, while virulence tests suggest that sublethal doses of these terpenes have no effect on the host-killing performance of EPNs.
The Role of Bispecific Antibodies in Relapsed Refractory Multiple Myeloma: A Systematic Review
Authors: Khanam Razwana , Ashruf Omer S. , Waqar Syed Hamza Bin , Shah Zunairah , Batool Saba , Mehreen Rameesha , Pachika Pranali , Roksana Zinath , Rehman Mohammad Ebad Ur , Anwer Faiz
Published: May 2023

Multiple myeloma is a heterogeneous clonal malignant plasma cell disorder, which remains incurable despite the therapeutic armamentarium’s evolution. Bispecific antibodies (BsAbs) can bind simultaneously to the CD3 T-cell receptor and tumor antigen of myeloma cells, causing cell lysis. This systematic review of phase I/II/III clinical trials aimed to analyze the efficacy and safety of BsAbs in relapsed refractory multiple myeloma (RRMM). A thorough literature search was performed using PubMed, Cochrane Library, EMBASE, and major conference abstracts. A total of 18 phase I/II/III studies, including 1283 patients, met the inclusion criteria. Among the B-cell maturation antigen (BCMA)-targeting agents across 13 studies, the overall response rate (ORR) ranged between 25% and 100%, with complete response/stringent complete response (CR/sCR) between 7 and 38%, very good partial response (VGPR) between 5 and 92%, and partial response (PR) between 5 and 14%. Among the non-BCMA-targeting agents across five studies, the ORR ranged between 60 and 100%, with CR/sCR seen in 19–63%, and VGPR in 21–65%. The common adverse events were cytokine release syndrome (17–82%), anemia (5–52%), neutropenia (12–75%), and thrombocytopenia (14–42%). BsAbs have shown promising efficacy against RRMM cohorts with a good safety profile. Upcoming phase II/III trials are much awaited, along with the study of other agents in concert with BsAbs to gauge response.
Influence of Several Heat Treatments on Residual Stress in Laser Powder Bed-Fused Maraging 18Ni-300 Steel
Authors: Yu Jae Hyun , Jin Qing-Ye , Ha Kyeongsik , Lee Wookjin
Published: May 2023

In laser powder bed fusion, process-inherited thermal residual stress is developed due to the thermal strain misfit between each layer. Detailed analysis and a prediction of the residual stress are needed because it can induce distortions of the components and, in some serious cases, stress-induced defects such as cracking. In this work, the effects of heat treatment conditions on residual stress in maraging 18Ni-300 steel, fabricated by laser powder bed fusion, were investigated. Cantilever-shaped specimens were used to experimentally analyze residual stress caused by the distortions of the specimens while cutting them from the supporters. The cantilever samples showed complex distortion behavior in the as-built state. They bent downward while cutting them from the supporter when the thickness was relatively thin, and the bending deformation became upward instead of downward with increasing thickness. Interpreting this behavior by finite element simulation showed that the downward bending was due to the compressive stress state at the top layer of the maraging steel. When the cantilever specimens were aging heat treated, the distortions were significantly reduced, implying that the process-inherited residual stress was diminished.
A Review of Medical Diagnostic Video Analysis Using Deep Learning Techniques
Authors: Farhad Moomal , Masud Mohammad Mehedy , Beg Azam , Ahmad Amir , Ahmed Luai
Published: May 2023

The automated analysis of medical diagnostic videos, such as ultrasound and endoscopy, provides significant benefits in clinical practice by improving the efficiency and accuracy of diagnosis. Deep learning techniques show remarkable success in analyzing these videos by automating tasks such as classification, detection, and segmentation. In this paper, we review the application of deep learning techniques for analyzing medical diagnostic videos, with a focus on ultrasound and endoscopy. The methodology for selecting the papers consists of two major steps. First, we selected around 350 papers based on the relevance of their titles to our topic. Second, we chose the research articles that focus on deep learning and medical diagnostic videos based on our inclusion and exclusion criteria. We found that convolutional neural networks (CNNs) and long short-term memory (LSTM) are the two most commonly used models that achieve good results in analyzing different types of medical videos. We also found various limitations and open challenges. We highlight the limitations and open challenges in this field, such as labeling and preprocessing of medical videos, class imbalance, and time complexity, as well as incorporating expert knowledge, k-shot learning, live feedback from experts, and medical history with video data. Our review can encourage collaborative research with domain experts and patients to improve the diagnosis of diseases from medical videos.
Intelligent Blasthole Detection of Roadway Working Face Based on Improved YOLOv7 Network
Authors: Pan Shan , Tian Zijian , Qin Yifeng , Yue Zhongwen , Yu Ting
Published: May 2023

Blasthole detection is crucial but challenging in tedious underground mining processes, given the diversity of surrounding rock backgrounds and uneven light intensity. However, existing algorithms have limitations in extracting image features and identifying differently sized objects. This study proposes a cascade-network-based blasthole detection method. The proposed method includes a blasthole feature extract transformation (BFET) module and a blasthole detection (BD) module. Firstly, we constructed the BFET module on the improved Cycle Generative Adversarial Network (CycleGAN) by multi-scale feature fusion. Then, we fused the convolution features of the generators in CycleGAN to obtain the enhanced feature map of the blasthole images. Secondly, the BD module was cascaded with the BFET module to accomplish the task of detecting blastholes. Results indicated that the detection accuracy of the blasthole image was significantly improved by strengthening the contrast of the image and suppressing over-exposure. The experimental results also showed that the proposed method enhanced the contrast of the image and could improve the accuracy of blasthole detection in real time. Compared with the YOLOv7 and CycleGAN+YOLOv7 methods, the detection accuracy of our method was improved by 5.34% and 2.38%, respectively.