bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasma Phosphorylated-tau181 is a Predictor of Post-Stroke Cognitive Impairment: A Longitudinal Study
Authors: Huang Li-Kai , Chao Shu-Ping , Hu Chaur-Jong , Lo Yu-Chun , Hsieh Yi-Chen
Published: July 2021

IntroductionPost-stroke cognitive impairment (PSCI) cannot be neglected because it drastically influences the daily life of patients and their families. However, there are no studies exploring the association between preclinical blood biomarkers of neurodegeneration including plasma amyloid-β (Aβ), tau and brain-derived neurotrophic factor (BDNF) together with the risk of PSCI. The present longitudinal study was to investigate whether these blood biomarkers with imaging markers of cerebral small vessel disease can improve the prediction for PSCI. In addition, we also explored the association between blood biomarkers with the trajectories of PSCI.MethodsAdult patients with first ever acute ischemic stroke were recruited, and the cognitive and functional abilities of these patients were evaluated. Furthermore, blood biomarkers of neurodegeneration including plasma Aβ-40, Aβ-42, total tau, phosphorylated tau 181 (p-tau181), and BDNF levels and image markers of cerebral small vessel disease were measured. Each patient was followed up at 3 and 12 months at the outpatient department.ResultsOf 136 patients, 40 and 50 patients developed PSCI at 3 and 12 months after stroke, respectively. In functional trajectories, 27 patients did not have PSCI at 3 months but did at 12 months. By contrast, the PSCI status of 17 patients at 3 months was reversed at 12 months. Patients with high acute plasma p-tau181 had a significantly lower PSCI risk at 3 months (odds ratio [OR] = 0.62, 95% confidence interval [CI] = 0.40–0.94, p = 0.0243) and 12 months (OR = 0.69, 95% CI = 0.47–0.99, p = 0.0443) after adjustment for covariates and image biomarkers. Discrimination and reclassification statistics indicated that the p-tau181 level can improve discrimination ability for PSCI at 3 and 12 months, respectively. Additionally, the plasma p-tau181 level was the highest in subjects without PSCI followed by those with delayed-onset PSCI and early-onset PSCI with reversal, whereas the lowest plasma p-tau181 level was found among those with persistent PSCI, showing a significant trend test (p = 0.0081).ConclusionsPlasma p-tau181 is a potential biomarker for predicting early- and delayed-onset PSCI. Future studies should incorporate plasma p-tau181 as indicator for timely cognitive intervention in the follow-up of patients with stroke.
Optimized Carrier Extraction at Interfaces for 23.6% Efficient Tin–Lead Perovskite Solar Cells
Authors: Hu Shuaifeng , Otsuka Kento , Murdey Richard , Nakamura Tomoya , Truong Minh Anh , Yamada Takumi , Handa Taketo , Matsuda Kazuhiro , Nakano Kyohei , Sato Atsushi , Marumoto Kazuhiro , Tajima Keisuke , Kanemitsu Yoshihiko , Wakamiya Atsushi
Published: July 2021

Carrier extraction is a key issue which limits the efficiency of perovskite solar cells. In this work, carrier extraction is improved by modifying the perovskite layers with a combination of ethylenediammonium diiodide post-treatment and glycine hydrochloride additive. Ethylenediammonium dications primarily affect the top surface of the perovskite films, while glycinium cations preferentially accumulate at the bottom region. The top and bottom interface modifications improve the crystallinity of the perovskite films and lower the density of electrical traps via surface passivation effects, resulting in long charge carrier lifetimes. The orientated aggregation of the ethylenediammonium and glycinium cations at the charge collection interfaces result in the formation of surface dipoles, which facilitate charge extraction. The performance of the treated solar cell devices also increases. The fill factor rose to 0.82, and the power conversion efficiency reaches 23.6% (23.1% certified). The open circuit voltage reaches 0.91 V, just 0.06 V below the Shockley–Queisser limit. The unencapsulated devices also show improved stability under AM 1.5G, retaining over 80% of the initial efficiency after 200 h continuous operation in inert atmosphere. Our strategy is also successfully applied to centimeter-scale devices, with efficiencies up to 21.0%.
Chiral Generation of Hot Carriers for Polarization-Sensitive Plasmonic Photocatalysis with Hybrid Nanostructures
Authors: Negrin-Montecelo Yoel , Movsesyan Artur , Gao Jie , Burger Sven , Wang Zhiming , Nlate Sylvain , Pouget Emilie , Oda Reiko , Comesana-Hermo Miguel , Govorov Alexander , Correa-Duarte Miguel
Published: July 2021

Mastering the manipulation of chirality at the nanoscale has long been a priority for chemists, physicists and materials scientists, given its importance in the biochemical processes of the natural world and in the development of novel technologies. In this vein, the formation of novel metamaterials and sensing platforms resulting from the synergic combination of chirality and plasmonics has opened new avenues in nano-optics. Recently, the implementation of chiral plasmonic nanostructures in photocatalysis has been proposed theoretically as a means to drive polarization-dependent photochemistry. Nevertheless, the lack of synthetic procedures leading to the formation of robust plasmonic photocatalysts with chiroptical features has hindered the advancement of this field. In the present work, we demonstrate that the use of inorganic nanometric chiral templates for the controlled assembly of Au and TiO2 nanoparticles leads to the formation of plasmon-based photocatalysts with polarization-dependent reactivity. The formation of plasmonic assemblies with chiroptical activities induces the asymmetric formation of hot electrons and holes generated via electromagnetic excitation, opening the door to novel photocatalytic and optoelectronic features. More precisely, we demonstrate that the reaction yield can be improved when the helicity of the circularly polarized light used to activate the plasmonic component matches the handedness of the chiral substrate. Our approach may enable new applications in the fields of chirality and photocatalysis, particularly toward plasmon-induced chiral photochemistry.
Prognostic impact of co-expression of LLCL2 and SLC7A5 in ERα-positive breast cancer patients
Authors: Hisada Tomoka , Kondo Naoto , Wanifuchi-Endo Yumi , Osaga Satoshi , Fujita Takashi , Asano Tomoko , Uemoto Yasuaki , Nishikawa Sayaka , Katagiri Yusuke , Terada Mitsuo , Kato Akiko , Sugiura Hiroshi , Okuda Katsuhiro , Kato Hiroyuki , Komura Masayuki , Morita Satoshi , Takahashi Satoru , Toyama Tatsuya
Published: July 2021

Background

Lethal giant larvae homolog 2 (LLGL2) functions as a promoter of tumor growth and localizes at cell junctions and membranes with solute carrier family 7 member 5 (SLC7A5) in estrogen receptor α (ERα)-positive breast cancer. LLGL2 and SLC7A5 have been reported to be involved in resistance to endocrine therapy. This study aimed to assess the effects of LLGL2/SLC7A5 co-expression in predicting prognosis and response to endocrine therapy in ERα-positive breast cancer patients.
Methods

The associations of clinicopathological factors with LLGL2 and SLC7A5 expression or LLGL2/SLC7A5 co-expression at the mRNA and protein level were assessed in invasive breast cancer patients with long-term follow-up. The median follow-up period was approximately10 years. Survival curves were analyzed using the Kaplan–Meier method and verified by the log-rank test. A Cox proportional hazards regression analysis was used for univariate and multivariate analyses of prognostic values using stepwise linear regression.
Results

We identified a positive association between low mRNA expression of LLGL2 or SLC7A5 alone and longer disease-free survival (DFS) and overall survival (OS) in ERα-positive breast cancer patients, but not in ERα-negative patients. We also identified that low LLGL2/SLC7A5 mRNA co-expression (LLGL2low/SLC7A5low) was associated with longer survival compared with other combination groups in all breast cancer patients. In ERα-positive breast cancer patients, LLGL2low/SLC7A5low showed longer survival compared with LLGL2high/SLC7A5high and a positive trend of longer survival compared with other combination groups. We also observed that LLGL2low/SLC7A5low showed longer survival compared with LLGL2high/SLC7A5high in ERα-positive breast cancer patients receiving adjuvant tamoxifen therapy. Multivariate analysis demonstrated that LLGL2low/SLC7A5low was an independent favorable prognostic factor of both DFS and OS in ERα-positive breast cancer patients. High co-expression of LLGL2 and SLC7A5 protein showed a positive trend of shorter survival.
Conclusions

Our study showed that co-expression of LLGL2 and SLC7A5 mRNA is a promising candidate biomarker and suggested that the LLGL2–SLC7A5 axis may be a therapeutic target in early breast cancer patients, especially in those receiving adjuvant tamoxifen therapy.
Investigating Wear and Predicting Lifetime of the Roller Cavities for the Net-shape Blade Rolling
Authors: Jin Qichao , Wang Wenhu , Jiang Ruisong , Guo lei
Published: July 2021

The die undergoing severe loads which induces inevitably wear in the pressure forming process, and the wear of die arouses obsessions about the die’s service lifetime. In order to obtain the geometrical shape transformation caused by wear and predict the service lifetime for a pair of rollers in net-shape blade rolling process, this paper quantified the distributions and evolutions of the local wear over roller cavities based on the local contact load responses, and predicted the lifetime which related to wear by a mathematical models. Firstly, the net-shape blade rolling process and the local contact load responses were summarized. Then, an improved wear model was provided based on the Archard formula, and the impact factors of the model was standardized by a regression analysis experiment. The transient wear distributions and evolutions over the roller cavities were enumerated, and the wear distribution for one rolling cycle was calculated based on wear accumulation effect. Finally, a lifetime prediction model was proposed to predict the service lifetime of the rollers according to the wear accumulation effect, and an experimental verification was carried out to validate the model. The results showed that the wear model and lifetime prediction model can be used for investigating the wear and lifetime prediction of the roller cavities for the net-shape blade rolling process.
H13 Subtype Avian Influenza Viruses Are Crossing Host Species Barrier From Wild Waterfowl to Land Fowl
Authors: SUN Weiyang , ZHAO Menglin , YU Zhijun , LI Yuanguo , ZHANG Xinghai , FENG Na , WANG Tiecheng , WANG Hongmei , HE Hongbin , ZHAO Yongkun , YANG Songtao , XIA Xianzhu , Gao Yuwei
Published: July 2021

The avian influenza virus H13 subtype circulates primarily in waterfowl. To explore the ability of the H13 virus to cross the host barriers, we genetically analysed two H13 isolates from wild birds in China and evaluated the infectivity of these subtypes in chickens. Genetic and molecular analyses showed differences in the lineages and amino acid sequences between the two subtypes; A/mallard/Dalian/DZ-137/2013 (H13N6) belonged to Group I, while A/Eurasian Curlew/Liaoning/ZH-385/2014 (H13N8) belonged to Group III. The nucleotide sequence results showed high homology (approximately 96.9%-100%) to sequences in GenBank. Neither H13 isolate replicated in adult chickens or 20-day-old chicks; however, the H13N8 strain replicated in 1- and 10-day-old chicks. Viruses were recovered from the nasal turbinate, tracheal, lung and colon tissues of chicks at 1, 3 and 5 days post-inoculation. The H13N6 isolates replicated inefficiently in 1-day-old chicks and did not replicate in 10-day-old chicks. Serological surveillance results showed that domestic chickens had a 4.6%-10.4% (15/328-34/328) positive antibody titre to the H13 virus. H13N6 and H13N8 isolates replicated in mammalian cell lines, including 293T, Madin-Darby canine kidney and chicken embryo fibroblast cells. Our results suggest that the AIV H13 subtype may cross the host barrier from wild waterfowl to land fowl.
Folk Medicinal Use of Some Animals and Their Products in Wolaita, Southern Ethiopia
Authors: Wendimu Abenezer , Tekalign Wondimagegnehu
Published: July 2021

Background

Ethiopia is endowed with a diverse set of floral and faunal resources that are useful to human beings in one or another ways. A faunal resource has played a significant role in human life from the earliest days of recorded history for medicinal purposes to treat different ailments and is still common in many parts of the world.
Methods

A field survey was carried out in Diguna Fango district from March 2021 to June 2021 by personal interviews through semi-structured questionnaires and open group discussions.
Results

Altogether 200 (125 male and 75 female) informants provided information regarding the therapeutic uses of different animal parts/products. A total of 39 animal parts/products used for the treatment of 159 different ailments were identified. Mammals occupied the highest use report 26(66.67%), followed by arthropods 5(12.81%) and avian species 4(10.26%). Further, some most popular zootherapeutic animals i.e. Phacochoerus africanus, Hystrix cristata, Bos taurus, Equus africanus asinus, Homo sapiens, etc. were used to treat more than three different ailments. Anemia, asthma, bone fractures, cold, evil eye, fever, pleurisy, rheumatism, skin disease, and stomach pain were some of the frequently occurring ailments. The most frequently used route was dermal (72%), followed by oral and nasal routes each with 14%. Drinking 32(33%), eating 25(26%), and tying 11(11.30%) were the major modes of application. Fidelity level showed the leg of Bos taurus and fur of Lepus fagani with the highest (FL = 100%) to treat slipped disc and wound, respectively. The highest value of the RFC index was scored by Bos taurus (RFC = 1).
Conclusion

The results show that there’s a wealth of ethnozoological knowledge to be documented which could be of use in developing new drugs. Hence, it’s hoped that the knowledge contained during the paper is going be useful in future ethnozoological, ethnopharmacological, and conservation-related research of the region.
Comparative genomics and polyploid dynamics in tetraploid cotton (Gossypium)
Authors: Peng Renhai , Xu Yanchao , Liu Zhen , Chen Liyang , Zhou Zhongli , Cai Xiaoyan , Wang Kunbo , Wei Yangyang , Liu Yuling , Wang Heng , Hu Guan-jing , Grover Corrinne , Hou Yuqing , Wang Yuhong , Li Pengtao , Wang Tao , Lu Qaunwei , Wang Yuanyuan , Wang Qinlian , Tian Shilin , Wendel Jonathan , Liu Fang
Published: July 2021

Allotetraploid species of cotton (Gossypium) represent a model system for the study of plant polyploidy, molecular evolution and domestication. In this study three high-quality draft assemblies of tetraploid cottons are presented, comprising one early form of domesticated Gossypium hirsutum (AD1-genome, Gh), i.e., Gossypium hirsutum race punctatum (GhP), and two recently described wild species of tetraploid cotton, G. ekmanianum (AD6, Ge) and G. stephensii (AD7, Gs). Using comparative phylogenomics, we confirm a monophyletic origin of tetraploid Gossypium and provide a dated whole-genome level perspective for the evolution of the clade. Recombination and patterns of selection are asymmetric between the two co-resident genomes in the allopolyploid nucleus. Considerable gene structural variation occurs widely within homoeologous genomes and between heterologous genomes during evolution and domestication. Despite few large-scale chromosomal structure variations among tetraploid cotton, frequent homoeologous exchanges between subgenomes in all species have contributed to diversity and asymmetrically between subgenomes. Abiotic and biotic adaptive evolution was driven by various evolutionary forces, leading to transcriptome change and gene family expansion. Our study marks a milestone in modern polyploid crop research, completing genome sequencing for all species of polyploid Gossypium, and will facilitate a better understanding of the genomic landscape and crop improvement dynamics of polyploids.
Factors Affecting Squatting Ability in Total Knee Arthroplasty Using High Flexion Prosthesis
Authors: Li Tiejian , Sun Jingyang , Du Yinqiao , Gao Zhisen , Ma Haiyang , Zhou Yonggang
Published: July 2021

Background: Total knee arthroplasty (TKA) is widely used as a treatment for knee osteoarthritis. Few studies have analyzed the factors affecting squatting ability of patients after TKA. The purpose of this study is to comprehensively analyze the factors affecting squatting ability after TKA and to determine which important factors should be paid attention to.Methods: Three hundred primary TKA cases with a minimum 3-year follow-up were retrospectively analyzed. All patients received a conventional posterior-stabilized TKA implant and underwent a standard perioperative care pathway. The patients were divided into two groups according to the knee flexion angle (Group I -squatting group, Group II - inability squatting group). Demographic, operative, and clinical data were collected. Radiographic assessment included joint line joint line elevation, patella position, posterior condylar offset (PCO) , etc. Statistical analysis of effect of all the above factors on squatting ability was done. Results: The univariate analysis showed age, prosthesis size, preoperative ROM and joint line position were correlated with squatting ability (p-values ≤0.10). In the final multivariate analysis, joint line position and preoperative ROM were independent influencing factors that affecting squatting ability after TKA (p-values < 0.01). Conclusion: Preoperative ROM and joint line position were independent influencing factors affecting squatting ability after TKA. Patients should be counseled accordingly and made to understand these factors. In order to ensure patients can squat postoperatively, we should improve surgical techniques to control joint line elevation.
Fabrication of a stable light-activated and p/n type AgVO3/V2O5-TiO2 heterojunction for pollutants removal and photoelectrochemical water splitting
Authors: Yu Hai , Miao Zhang , Wang Yanfen , Lv Jianguo , Yang Lei , Liu Yanmei , Gao Qian , He Gang , Sun Zhaoqi
Published: July 2021

In this study, TiO2 nanorod arrays (TiO2) was fabricated and modified with the AgVO3 quantum dots (QDs) decorate on interfacing few-layer V2O5 to form a heterojunction material for removal pollutants and photoelectrochemical (PCE) water splitting. The AgVO3/V2O5-TiO2 nanorod arrays (AgVO3/V2O5-TiO2) synthesized by the secondary hydrothermal method were loaded with conductive glass, which facilitated the formation of one-dimensional (1D) nanorod and p-n junction structures. Through instrumentations, to investigate the structural, morphological, optical, photocatalytic and PCE characteristics of the materials. The TiO2 modified by AgVO3 and V2O5 can significantly improve the visible light optical absorption, the reduce the electron-hole pair binding rate and shorten the band gap (3.07-1.41eV) of TiO2. The resulting photocurrent density (116uA/cm2 ) and photodegradation efficiency (rate constant, k = 0.025min− 1) of AgVO3/V2O5-TiO2 are approximately 20 (6uA/cm2) and 5 times (0.005min− 1) higher than those of bare TiO2, respectively. The AgVO3/V2O5-TiO2 achieved a current density of 10mA at an overpotential of 246.2mV and exhibited excellent oxygen evolution reaction (OER) performance. The systematic PEC experiments concluded that the optimized of the TiO2 interface by AgVO3 and V2O5 could promote the separation and transport of charge carriers.
Strategy of extra Zr doping on the enhancement of thermoelectric performance for TiZrxNiSn synthesized by a modified solid-state reaction
Authors: Chen Jun-Liang , Yang Hengquan , Liu Chengyan , Liang Jisheng , Miao Lei , Zhang Zhongwei , Liu Pengfei , Yoshida Kenta , Chen Chen , Zhang Qian , Zhou Qi , Liao Yuntiao , Wang Ping , Li Zhixia , Peng Biaolin
Published: July 2021

Half-Heusler alloys, which possess the advantages of high thermal stability, large power factor and good mechanical property, have been attracted increasing interest in mid-temperature thermoelectric application. In this work, the extra Zr-doped TiZrxNiSn samples were successfully prepared by a modified solid-state reaction followed by spark plasma sintering. It demonstrates that extra Zr doping could not only improve the power factor on account of an increase in Seebeck coefficient but also suppress the lattice thermal conductivity originated from the strengthened phonon scattering by the superlattice nanodomains and the secondary nanoparticles. As a consequence, an increased power factor of 3.29 mW m− 1 K− 2 and a decreased lattice thermal conductivity of 1.74 W m− 1 K− 1 are achieved in TiZr0.015NiSn, leading to a peak ZT as high as 0.88 at 773 K and an average ZT value up to 0.62 in the temperature range of 373 − 773 K. This work gives a guidance for optimizing the thermoelectric performance of TiNiSn-based alloys by modulating the microstructures on the secondary nanophases and superlattice nanodomains.
Effect of Goal-directed Haemodynamic Therapy Guided by Non-invasive Monitoring on Perioperative Complications in Elderly Hip Fracture Patients Within an Enhanced Recovery Pathway.
Authors: Lorente Juan Victor , Reguant Francesca , Arnau Anna , Borderas Marcelo , Prieto Juan Carlos , Torrallardona Jordi , Carrasco Laura , Solano Patricia , Pérez Isabel , Farré Carla , Jiménez Ignacio , Ripollés-Melchor Javier , Monge Manuel Ignacio , Bosch Joan
Published: July 2021

Background: Goal-Directed Hemodynamic Therapy (GDHT) has been shown to reduce morbidity and mortality in high-risk surgical patients. However, there is little evidence of its efficacy in patients undergoing hip fracture surgery. This study aims to evaluate the effect of GDHT guided by non-invasive haemodynamic monitoring on perioperative complications in patients undergoing hip fracture surgery.Methods: Patients > 64 years undergoing hip fracture surgery within an Enhanced Recovery Pathway were enrolled in this single-center, non-randomized, intervention study with a historical control group and 12-months follow-up. Exclusion criteria were patients with pathological fractures, traffic-related fractures and refractures. Control group patients received the standard care given at our hospital. Intervention group patients received an individualized management strategy aimed at achieving an optimal stroke volume by fluid administration, in addition to a systolic blood pressure > 90 mmHg and an optimal cardiac index according to the patient's age and baseline metabolic equivalents. No changes were made between groups in the enhanced recovery protocols, nor in the composition of the multidisciplinary team during the study period. Primary combined outcome was perioperative complications. Intraoperatively: haemodynamic instability, sustained cardiac arrhythmias. Postoperative complications: cardiovascular, respiratory, infectious and renal complications. Secondary outcomes were administered fluids, vasopressor requirements, perioperative transfusion, length of hospital stay, readmission and one-year survival.Results: 551 patients (Control group=272; Intervention group=279). Intraoperative haemodynamic instability was lower in the intervention group (37.5% vs 28.0%; p=0.017). GDHT patients had fewer postoperative cardiovascular (18.8% vs 7.2%; p < 0.001), respiratory (15.1% vs 3.6%; p<0.001) and infectious complications (21% vs 3.9%; p<0.001) but not renal (12.1% vs 33.7%; p<0.001). Intervention group patients had less vasopressors requirements (p<0.001) and received less fluids (p=0.001) than control group. Fewer patients required transfusion in GDHT group (p<0.001). For intervention group patients, median length of hospital stay was shorter (p < 0.001) and one-year survival higher (p<0.003).Conclusions: The use of GDHT decreases intraoperative complications and postoperative cardiovascular, respiratory and infectious but not postoperative renal complications. This strategy was associated with a shorter hospital stay and increased one-year survival.Trial registration: Clinicaltrials.gov: NCT02479321
Melatonin attenuates radiation-induced cortical bone-derived stem cells injury and enhances bone repair in postradiation femoral defect model
Authors: Hu Wei , Liang Jiawu , Liao Song , Zhao Zhidong , Wang Yuxing , Mao Xiaofei , Hao Siwei , Wang Yifan , Guo Bin
Published: July 2021

Background
Ionizing radiation poses a challenge to the healing of bone defects. Radiation therapy and accidental exposure to gamma-ray (γ-ray) radiation inhibit bone formation and increase the risk of fractures. Cortical bone-derived stem cells (CBSCs) are essential for osteogenic lineages, bone maintenance, and repair. This study aimed to investigate the effects of melatonin on postradiation CBSCs and bone defects.
Methods
CBSCs were extracted from C57/BL6 mice and were identified by flow cytometry. The effects of exogenous melatonin on the self-renewal and osteogenic capacity of postradiation CBSCs were detected in vitro. The underlying mechanisms in terms of genomic stability, apoptosis and oxidative stress-related signaling were further analyzed by western blotting, flow cytometry and immunofluorescence. Finally, the effects of melatonin on healing in postradiation bone defects were evaluated in vivo by micro-CT and immunohistochemical analysis.
Results
The radiation-induced reduced self-renewal and osteogenic capacity were partially reversed in postradiation CBSCs treated with melatonin. Melatonin maintained the genomic stability and apoptosis of postradiation CBSCs, and intracellular oxidative stress was decreased significantly while antioxidant-related enzymes were enhanced. Western blotting verified the anti-inflammatory effect of melatonin by downregulating the levels of IL-6 and TNF-α via extracellular regulated kinase (ERK)/nuclear factor erythroid 2-related factor 2 (NRF2)/heme oxygenase 1 (HO-1) signaling, distinct from its antioxidant effect via NRF2 signaling. In vivo experiments demonstrated that the newly formed bone in the melatonin plus Matrigel group had higher trabecular bone volume per tissue volume (BV/TV) and bone mineral density (BMD) values, and lower levels of IL-6 and TNF-α than those in the irradiation and the Matrigel groups.
Conclusions
This study suggested the potential of melatonin to protect CBSCs against γ-ray radiation and to assist the healing of postradiation bone defects.
The affiliative use of emoji and hashtags in the Black Lives Matter movement: A Twitter case study
Authors: Alfano Mark , Reimann Ritsaart , Quintana Ignacio , Cheong Marc , Klein Colin
Published: July 2021

Protests and counter-protests seek to draw and direct attention and concern with confronting images and slogans. In recent years, as protests and counter-protests have partially migrated to the digital space, such images and slogans have also gone online. Two main ways in which these images and slogans are translated to the online space is through the use of emoji and hashtags. Despite sustained academic interest in online protests, hashtag activism and the use of emoji across social media platforms, little is known about the specific functional role that emoji and hashtags play in online social movements. In an effort to fill this gap, the current paper studies both hashtags and emoji in the context of the Twitter discourse around the Black Lives Matter movement.
The Psychological Impact and suicidal behaviour in the context of COVID-19 pandemic, A Four Case report from Oman
Authors: maqbali Mandhar Al , Al-Huseini Salim , Eltanahy Ahmad Mohamed , Elawdy Mohamed
Published: July 2021

Background:Mandatory quarantine during COVID-19 has disrupted normal social and economic life and many people became trapped and isolated with increasing levels of anxiety and financial difficulties. Especially for vulnerable people, the COVID-19 pandemic had shown by many studies to increase the depressive and anxiety symptoms as well as suicidal ideation and suicidal attempts. Increased suicidal attempts had been associated with the increased burden of the health and economic impacts of the pandemic.Cases Presentation:Here, we report four cases of suicidal attempts during the COVID 19 outbreak due to the lockdown and related economic difficulties. Those cases were admitted to a general hospital from the period April 2020 to June 2020. All patients were males, tested negative for coronavirus and used violent methods of suicide. After receiving the appropriate treatment, all cases were discharged from the hospital.Conclusion:The COVID-19 pandemic and its economic and social impacts could result in significant consequences on vulnerable persons. As shown by many studies, Screening and early treatment are of paramount importance in preventing the mental health complications of the pandemic
Application of the concept of reflection in majejahitan activity by Bali Mulia society
Authors: Darmayasa Jero Budi , Wahyudin Wahyudin , Mulyana Tatang
Published: July 2021

This research is qualitative research with case study method. The focus of this research is to explore the value of ethnomathematics in the culture of the Bali Mula society in the Kintamani sub-district, Bali Province. The research starts from the exploration phase of ethnomathematics, mapping ethnomathematics with school mathematics, explores aspects of pedagogy in the preservation of ethnomathematics and concludes on how ethnomathematics is applied to mathematics learning in schools. Data collection was carried out through observation of Mejejahitan activities carried out by Bali Mula women. Data from observations are then linked to the results of documentation analysis and strengthened by the results of interviews. The triangulation method is carried out to check the validity of the research data. Based on the results of data analysis there is a relationship between the activities of Mejejahitan with school mathematics. The mathematical concepts contained in the Majejahitan activity that is reflecting (reflecting) and predicting or predicting patterns. Because there is a relationship between Majejahitan activities with school mathematics, it can be said that there are ethnomathematics values in the culture of the Bali Mula society in Kintamani District, Bali Province.
Learning mathematics through Islam Nusantara culture: An etnomathematics study in Indonesia
Authors: Richardo Rino , Abdullah Ahmad Anis , Martyanti Adhetia , Sholihah Dyasih Alin , Nurshanti Widha
Published: July 2021

This study discusses the study of Islam Nusantara culture in mathematics learning. This research uses library method. The data obtained is a publication of research articles in a scientific journal. The article analyzed includes three stages, namely organize, synthesize, and identify. The results of data analysis show that (1) culture of Islam Nusantara can be used to teach a concept in learning mathematics, (2) this culture can be used as material in strengthening character education, (3) and this culture can develop the ability of cultural literacy.
Etnomatematika pada bangunan Umbul Binangun Taman Sari dalam aktivitas pembelajaran matematika
Authors: Putra Ryopanintama Yuniar , Alviyan Davet Nur , Arigiyati Tri Astuti , Kuncoro Krida Singgih
Published: July 2021

Penelitian ini dilakukan untuk menemukan unsur-unsur matematika (etnomatematika) pada bangunan Umbul Binangun. Metode penelitian yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan etnografi. Data-data yang dipakai adalah data yang didapat dari studi literatur, observasi, dokumentasi, dan wawancara. Observasi dan dokumentasi digunakan untuk mengidentifikasi etnomatematika pada bangunan Umbul Binangun. Sedangkan literatur dan wawancara digunakan untuk mengetahui lebih dalam nilai-nilai budaya yang ada pada bangunan Umbul Binangun. Hasil dari penelitian ini adalah terdapat unsur-unsur matematika (etnomatematika) pada bangunan Umbul Binangun, yaitu konsep persegi panjang, lingkaran, belah ketupat, dan garis sejajar.  Melalui kegiatan mengamati bangunan Umbul Binangun dalam pembelajaran matematika dengan pendekatan etnomatematika menjelaskan bahwa unsur budaya dapat digunakan dalam pembelajaran matematika.Ethnomathematics at Umbul Binangun Building for geometry learningAbstractThis research was conducted to find mathematical elements (ethnomathematics) in the Umbul Binangun building. The research method used in this research is a qualitative method with an ethnographic approach. The data used are data obtained from literature studies, observation, documentation, and interviews. Observation and documentation are used to identify ethnomathematics in the Umbul Binangun building. Meanwhile, literature and interviews are used to read more deeply about the cultural values that exist in the Umbul Binangun building. This study's results show elements of mathematics (ethnomathematics) in the Umbul Binangun building, namely the concept of rectangles, circles, rhombuses, and parallel lines. Observing the Umbul Binangun building in mathematics learning with ethnomathematics explains that cultural elements can be used in learning mathematics
Eksplorasi etnomatematika Museum Kereta Kraton Yogyakarta dan pengintegrasiannya ke dalam pembelajaran matematika
Authors: Setiana Dafid Slamet , Ayuningtyas Annis Deshinta , Wijayanto Zainnur , Kusumaningrum Betty
Published: July 2021

Penelitian ini bertujuan untuk mengeksplorasi unsur etnomatematika Museum Kereta Kraton Yogyakarta dan mengintegrasikannya ke dalam pembelajaran matematika. Jenis penelitian ini yaitu penelitian eksploratif. Data yang diperoleh berupa data kualitatif, sumber data penelitian diperoleh melalui observasi, wawancara, dokumentasi, dan studi literatur yang berkaitan dengan Museum Kereta Kraton Yogyakarta. Teknik pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Analisis data dalam penelitian ini menggunakan metode kualitatif-verifikatif, yaitu suatu metode induktif dalam penarikan kesimpulan dimana data dijadikan sebagai dasar untuk menyimpulkan gambaran umum keadaan objek kajian. Hasil penelitian menunjukkan bahwa unsur etnomatematika Museum Kereta Kraton Yogyakarta dapat diintegrasikan ke dalam pembelajaran matematika, diantaranya konsep luas bangun datar, volume bangun ruang, kesimetrisan, dan teselasi/pengubinan. Konsep-konsep tersebut dapat diterapkan dalam pembelajaran matematika sebagai masalah kontesktual sekaligus sebagai salah satu cara mengenalkan unsur budaya kepada siswa sebagai upaya mengembangkan pendidikan karakter siswa.Ethnomathematics exploration at Museum of Kereta Kraton Yogyakarta and its integration in mathematics instructionAbstractThis study aims to identify the potential for integrating ethnomathematics at Yogyakarta, particularly the Museum of Kereta Kraton (Kraton Railway Museum) into mathematics learning. This type of research was a qualitative descriptive study. The data obtained in the form of qualitative data, the source of research data obtained through observation, interviews, documentation, and study of literature related to Yogyakarta Kraton Railway Museum. The data collection technique was done by observing, interviewing, and documenting. The data analysis in this study used a qualitative-verification method, which is an inductive method of drawing conclusions where the data is used as a basis for concluding a general description of the state of the object of study. The results showed that the ethnomathematics of Yogyakarta Kraton Railway Museum has the potential to be integrated into mathematics learning. Ethnomathematics that can be integrated includes the concept of flat area, volume of space, symmetry, and tessellation /tiling. These concepts can be applied in mathematics learning as a contextual geometry problem as well as a way of introducing cultural elements to students.
Key Challenges and Opportunities for Cloud Technology in Health Care: Semistructured Interview Study (Preprint)
Authors: Cresswell Kathrin , Domínguez Hernández Andrés , Williams Robin , Sheikh Aziz
Published: July 2021

BACKGROUND

The use of cloud computing (involving storage and processing of data on the internet) in health care has increasingly been highlighted as having great potential in facilitating data-driven innovations. Although some provider organizations are reaping the benefits of using cloud providers to store and process their data, others are lagging behind.

OBJECTIVE

We aim to explore the existing challenges and barriers to the use of cloud computing in health care settings and investigate how perceived risks can be addressed.

METHODS

We conducted a qualitative case study of cloud computing in health care settings, interviewing a range of individuals with perspectives on supply, implementation, adoption, and integration of cloud technology. Data were collected through a series of in-depth semistructured interviews exploring current applications, implementation approaches, challenges encountered, and visions for the future. The interviews were transcribed and thematically analyzed using NVivo 12 (QSR International). We coded the data based on a sociotechnical coding framework developed in related work.

RESULTS

We interviewed 23 individuals between September 2020 and November 2020, including professionals working across major cloud providers, health care provider organizations, innovators, small and medium-sized software vendors, and academic institutions. The participants were united by a common vision of a cloud-enabled ecosystem of applications and by drivers surrounding data-driven innovation. The identified barriers to progress included the cost of data migration and skill gaps to implement cloud technologies within provider organizations, the cultural shift required to move to externally hosted services, a lack of user pull as many benefits were not visible to those providing frontline care, and a lack of interoperability standards and central regulations.

CONCLUSIONS

Implementations need to be viewed as a digitally enabled transformation of services, driven by skill development, organizational change management, and user engagement, to facilitate the implementation and exploitation of cloud-based infrastructures and to maximize returns on investment.
Pemaknaan Simbolik pada Prosesi Kenduri Blang: Studi Kasus Gampong Ulee Gle Pidie Jaya
Authors: Anismar  , Rukaiyah  , Nasution Abdullah Akhyar
Published: July 2021

This study aims to determine the symbolic meaning of the kenduri blang procession in Gampong Ulee Gle Pidie Jaya. Researchers used qualitative-descriptive research methods. Data collection techniques are observation, interview, and document study. The results showed that the community interpreted kenduri blang as a symbol of gratitude and asked for blessings from Allah so that the next crop was bountiful. Besides that, kenduri blang can also strengthen the relationship between people to stay united and respect each other. Kenduri blang was held in September, precisely before the beginning of descending into the fields. The community participates by donating funds to buy buffalo, spices, and other necessities needed when the event is held.

Abstrak

Penelitian ini bertujuan untuk mengetahui makna simbolik dari prosesi kenduri blang di Gampong Ulee Gle Pidie Jaya. Peneliti menggunakan metode penelitian kualitatif-deskriptif. Teknik pengumpulan data yaitu observasi, wawancara, dan studi dokumen. Hasil penelitian menunjukkan bahwa masyarakat memaknai kenduri blang sebagai simbol kesyukuran dan meminta berkat dari Allah agar hasil panen berikutnya melimpah. Selain itu kenduri blang juga dimaknai sebagai pelestarian budaya Aceh, ajang memperkuat silaturrahmi antar masyarakat untuk tetap bersatu dan saling menghargai. Kenduri blang dilaksanakan pada bulan September tepatnya menjelang permulaan turun ke sawah. Masyarakat berpartisipasi dengan menyumbang dana untuk membeli kerbau, bumbu, dan keperluan lainnya yang dibutuhkan saat acara digelar.
Microstructurally small fatigue crack initiation behavior of fine and coarse grain simulated heat-affected zone microstructures in low carbon steels
Authors: Nishikawa Hide-aki , Furuya Yoshiyuki , Enoki Manabu , Enoki Manabu
Published: July 2021

Successive observation of fatigue crack initiation process was conducted
on six types of thermally simulated HAZ microstructures to clarify the
physical significance of fatigue life difference between coarse grain
(CG) and fine grain (FG) heat-affected zone (HAZ) microstructures. The
results showed the fatigue life-decreasing mechanism in the CGHAZ to be
successfully explained by acceleration of the shear mode fatigue crack
growth rate provided the crack is smaller than the prior austenite grain
size, based on the following experimental results. In other words, the
fatigue cracks initiated along the shear stress plane. In addition, the
prior austenite grain size of crack initiation life with the FG and
CGHAZ were comparable, since the shear mode fatigue crack growth rate of
the CGHAZ was faster than that of the FGHAZ. As a result, the remaining
fatigue life after the grain size crack initiation of the CGHAZ become
shorter than that of the FGHAZ as a function of grain size difference.
Deep brain stimulation of Anteromedial Globus Pallidus internus improved OCD rather than tics in a Tourette's syndrome patient
Authors: Aminzade Zahra , Fateh Sepand Tehrani , khoshnood Reza Jalili , Ashrafi Farzad , Salari Mehri
Published: July 2021

After performing DBS surgery on a patient with Tourette syndrome,
significant improvement was observed in OCD, but the tic remained
unchanged, which contradicts previous studies. Herein we discuss that
fluctuations in the therapeutic outcomes may be due to differences in
physiological conditions tic- or OCD-specified pathways.
The Recovery of an intravesical BCG-induced arthritis after RITUXIMAB treatment
Authors: amri Nejla El , Zeglaoui Héla , Hmila Salma , khalifa dhouha , Lataoui Sadok , Baccouche Khadija , Bouajina Elyes
Published: July 2021

BCG intra-vesical instillation is the standard of care for superficial
bladder cancer at high risk of relapse and progression. Yet, this
treatment can cause dysimmune complications. Osteoarticular
manifestations related to BCG therapy are rare and frequently mild. We
report a rare case of a severe form successfully treated with Rituximab.
Analysis of IgG, IgA, and IgM antibodies against SARS-CoV-2 spike protein S1 in convalescent and vaccinated patients with the Pfizer-BioNTech and CanSinoBio vaccines
Authors: Melgoza-González Edgar , Hinojosa-Trujillo Diana , Resendiz Monica , Mata-Haro Verónica , Hernández-Valenzuela Sofía , García-Vega Melissa , Bravo-Parra Marlene , ARVIZU-FLORES ALDO , Valenzuela Olivia , Velázquez Edgar , Soto-Gaxiola Alan , Gómez-Meza Martha , Pérez-Jacobo Fernando , Villela Luis , Hernández Jesús
Published: July 2021

The SARS-CoV-2 virus was detected for the first time in December 2019 in
Wuhan, China. Currently, this virus has spread around the world, and new
variants have emerged. This new pandemic virus provoked the rapid
development of diagnostic tools, therapies and vaccines to control this
new disease called COVID-19. Antibody detection by ELISA has been
broadly used to recognize the number of persons infected with this virus
or to evaluate the response of vaccinated individuals. As the pandemic
spread, new questions arose, such as the prevalence of antibodies after
natural infection and the response induced by the different vaccines. In
Mexico, as in other countries, mRNA and viral-vectored vaccines have
been widely used among the population. In this work, we developed an
indirect ELISA test to evaluate S1 antibodies in convalescent and
vaccinated individuals. By using this test, we showed that IgG
antibodies against the S1 protein of SARS-CoV-2 were detected up to 42
weeks after the onset of the symptoms, in contrast to IgA and IgM, which
decreased 14 weeks after the onset of symptoms. The evaluation of the
antibody response in individuals vaccinated with Pfizer-BioNTech and
CanSinoBio vaccines showed no differences two weeks after vaccination.
However, after completing the two doses of Pfizer-BioNTech and the one
dose of CanSinoBio, a significantly higher response of IgG antibodies
was observed in persons vaccinated with Pfizer-BioNTech than in those
vaccinated with CanSinoBio. In conclusion, these results confirm that
after natural infection with SARS-CoV-2, it is possible to detect
antibodies for up to ten months. Additionally, our results showed that
one dose of the CanSinoBio vaccine induces a lower response of IgG
antibodies than that induced by the complete scheme of the
Pfizer-BioNTech vaccine.
Approaches in the Photosynthetic Production of Sustainable Fuels by Cyanobacteria using Tools of Synthetic Biology
Authors: . Indrajeet , Rautela Akhil , Kumar Sanjay
Published: July 2021

Cyanobacteria, photosynthetic prokaryotic microorganisms having a simple
genetic composition are the prospective photoautotrophic cell factories
for the production of a wide range of biofuel molecules. Simple genetic
composition of cyanobacteria allows effortless genetic manipulation
which leads to increased research endeavour from the synthetic biology
approach. An improved development of synthetic biology tools, genetic
modification methods and advancement in transformation techniques to
construct a strain which can contain multiple target genes in single
operon will vastly expand the functions that can be used for engineering
photosynthetic cyanobacteria for the generation of biofuels. In this
review, recent advancements and approaches in synthetic biology tools
and biofuel production by metabolically engineered cyanobacteria have
been discussed. Various fuel molecules like isoprene, limonene,
α-farnesene, squalene, alkanes, butanol and fatty acids which can be a
substitute of petroleum and fossil fuels in future have been elaborated.
Becker Muscular Dystrophy (BMD) with Dilated Cardiomyopathy (DCM): A Case Report
Authors: Yongliang Chen , Yunlong Zhu , Yuying Zhou , Zeng Jianping
Published: July 2021

We report a case of a BMD complicated with dilated cardiomyopathy (DCM).
A 42-year-old male, his body posture and gait change began at the age of
23 years old. The patient experienced repeated shortness of breath when
he was 39 years old due to dilated cardiomyopathy.
Carotid access for percutaneous coronary intervention
Authors: Boulle Matthias De , Debing Erik , Belsack Dries , Vandeloo Bert
Published: July 2021

Vascular access for percutaneous coronary intervention (PCI) is usually
obtained through the radial or femoral, and to lesser extent the
brachial or ulnar artery. We describe the transcarotid approach for PCI
in a patient with severe peripheral artery disease. No adverse
neurological or cardiac events were observed.