bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Transverse Restraint on Welding Residual Stress in V-Groove Butt Welding
Authors: Park Jeongung , An Gyubaek , Ma Ninshu , Kim Seongjoon
Published: April 2022

When evaluating the safety of steel structures, welding residual stress is used as the secondary load and if there is any restraint, the yield stress of the base material is used for secondary load, regardless of the size of the restraint. Of late, as the yield stress of members is increasing with the increase in the use of high-strength steels, the proportion of the residual welding stress in the total load during the evaluation of the safety of structures is increasing. Therefore, it is necessary to investigate the effect of the size of the restraint on the residual welding stress, determine reasonable residual stress according to the size of the restraint, and apply the residual stress as a secondary load. To investigate the effect of constraint conditions on residual welding stress, thermoelastic–plastic analysis was performed for different member thicknesses, yield stresses, and constraint sizes. The restraint did not affect the residual stress in the direction of the weld line but did affect the residual stress in the direction perpendicular to the weld line. The restraint moved the tensile stress to the compression stress in the direction perpendicular to the weld line at the first layer of the weld and moved the compression stress to the tensile stress at the middle and final layers of the weld. The change in residual stress was the largest in the middle of the weld.
Designing Possibilistic Information Fusion—The Importance of Associativity, Consistency, and Redundancy
Authors: Holst Christoph-Alexander , Lohweg Volker
Published: April 2022

One of the main challenges in designing information fusion systems is to decide on the structure and order in which information is aggregated. The key criteria by which topologies are constructed include the associativity of fusion rules as well as the consistency and redundancy of information sources. Fusion topologies regarding these criteria are flexible in design, produce maximal specific information, and are robust against unreliable or defective sources. In this article, an automated data-driven design approach for possibilistic information fusion topologies is detailed that explicitly considers associativity, consistency, and redundancy. The proposed design is intended to handle epistemic uncertainty—that is, to result in robust topologies even in the case of lacking training data. The fusion design approach is evaluated on selected publicly available real-world datasets obtained from technical systems. Epistemic uncertainty is simulated by withholding parts of the training data. It is shown that, in this context, consistency as the sole design criterion results in topologies that are not robust. Including a redundancy metric leads to an improved robustness in the case of epistemic uncertainty.
Screening for Biofilm-Stimulating Factors in the Freshwater Planctomycete Planctopirus limnophila to Improve Sessile Growth in a Chemically Defined Medium
Authors: Kruppa Oscar , Czermak Peter
Published: April 2022

Planctomycetes such as Planctopirus limnophila offer a promising source of bioactive molecules, particularly when they switch from planktonic to sessile growth, but little is known about the corresponding biosynthetic gene clusters and how they are activated. We therefore screened for factors that promote sessile growth and biofilm formation to enable the cultivation of P. limnophila in a fixed-bed reactor. We carried out screening in microtiter plates focusing on biofilm formation and changes in optical density in response to various C:N ratios, metal ions, and oxidative stress. We used MTT assays and crystal violet staining to quantify biofilm formation. Positive factors were then validated in a fixed-bed bioreactor. The initial screen showed that D1ASO medium supplemented with NH4Cl to achieve a C:N ratio of 5.7:1, as well as 50 µM FeSO4 or CuSO4, increased the biofilm formation relative to the control medium. Exposure to H2O2 did not affect cell viability but stimulated biofilm formation. However, the same results were not replicated in the fixed-bed bioreactor, probably reflecting conditions that are unique to this environment such as the controlled pH and more vigorous aeration. Although we were able to cultivate P. limnophila in a fixed-bed bioreactor using a chemically defined medium, the factors that stimulate biofilm formation and inhibit planktonic growth were only identified in microtiter plates and further evaluation is required to establish optimal growth conditions in the bioreactor system.
Advances in Research of Short Peptides
Authors: Bojarska Joanna
Published: April 2022

Short peptides are unique biomolecules, which combine the advantages of classical small molecules and mature proteins and have attracted increasing interest due to their wide range of applications [...]
Preclinical Pharmacokinetic Studies of a Novel Diuretic Inhibiting Urea Transporters
Authors: Xu Yue , Zhang Hang , Li Nannan , Ma Wen , Wang Shuyuan , Sun Jianguo , Yang Baoxue
Published: April 2022

Urea transporter (UT) inhibitors are a class of promising novel diuretics that do not cause the imbalance of Na+, K+, Cl−, and other electrolytes. In our previous studies, 25a, a promising diuretic candidate inhibiting UT, was discovered and showed potent diuretic activities in rodents. Here, a sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of 25a in rat plasma, urine, feces, bile, and tissue homogenates was developed and validated to support the preclinical pharmacokinetic studies. The tissue distribution, excretion, and plasma protein binding were investigated in rats. After a single oral dose of 25a at 25, 50, and 100 mg/kg, the drug exposure increased linearly with the dose. The drug accumulation was observed after multiple oral doses compared to a single dose. In the distribution study, 25a exhibited a wide distribution to tissues with high blood perfusion, such as kidney, heart, lung, and spleen, and the lowest distribution in the brain and testis. The accumulative excretion rate of 25a was 0.14%, 3.16%, and 0.018% in urine, feces, and bile, respectively. The plasma protein binding of 25a was approximately 60% in rats and 40% in humans. This is the first study on the preclinical pharmacokinetic profiles of 25a.
Microstructural and Physicochemical Analysis of Collagens from the Skin of Lizardfish (Saurida tumbil Bloch, 1795) Extracted with Different Organic Acids
Authors: Jaziri Abdul Aziz , Shapawi Rossita , Mokhtar Ruzaidi Azli Mohd , Noordin Wan Norhana Md. , Huda Nurul
Published: April 2022

Marine fish collagen has attracted considerable attention due to its characteristics, including its biodegradability, biocompatibility, and weak antigenicity, and is considered a safer material compared to collagen from terrestrial animals. The aim of this study was to extract and characterize collagen from the skin of lizardfish (Saurida tumbil Bloch, 1795) with three different acids. The yields of acetic acid-extracted collagen (AESkC), lactic acid-extracted collagen (LESkC), and citric acid-extracted collagen (CESkC) were 11.73 ± 1.14%, 11.63 ± 1.10%, and 11.39 ± 1.05% (based on wet weight), respectively. All extracted collagens were categorized as type I collagen with mainly alpha chains (α1 and α2) detected and γ and β chains to some extent. Fourier transform infrared (FTIR) spectra showed an intact triple-helical structure in the AESkC, LESkC, and CESkC. UV-vis spectra and X-ray diffraction further demonstrated the similarity of the extracted collagens to previously reported fish skin collagens. AESkC (Tmax = 40.24 °C) had higher thermostability compared to LESkC (Tmax = 38.72 °C) and CESkC (Tmax = 36.74 °C). All samples were highly soluble in acidic pH and low concentrations of NaCl (0–20 g/L). Under field emission scanning electron microscopy (FESEM) observation, we noted the loose, fibrous, and porous structures of the collagens. The results suggest that the lizardfish skin collagens could be a potential alternative source of collagen, especially the AESkC due to its greater thermostability characteristic.
Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs
Authors: Hussain Haya , Ahmad Shujaat , Shah Syed Wadood Ali , Ullah Abid , Ali Niaz , Almehmadi Mazen , Ahmad Manzoor , Khalil Atif Ali Khan , Jamal Syed Babar , Ahmad Hanif , Halawi Mustafa
Published: April 2022

Alzheimer’s disease is an emerging health disorder associated with cognitive decline and memory loss. In this study, six curcumin analogs (1a–1f) were synthesized and screened for in vitro cholinesterase inhibitory potential. On the basis of promising results, they were further investigated for in vivo analysis using elevated plus maze (EPM), Y-maze, and novel object recognition (NOR) behavioral models. The binding mode of the synthesized compounds with the active sites of cholinesterases, and the involvement of the cholinergic system in brain hippocampus was determined. The synthesized curcumin analog 1d (p < 0.001, n = 6), and 1c (p < 0.01, n = 6) showed promising results by decreasing retention time in EPM, significantly increasing % SAP in Y-maze, while significantly (p < 0.001) enhancing the % discrimination index (DI) and the time exploring the novel objects in NORT mice behavioral models. A molecular docking study using MOE software was used for validation of the inhibition of cholinesterase(s). It has been indicated from the current research work that the synthesized curcumin analogs enhanced memory functions in mice models and could be used as valuable therapeutic molecules against neurodegenerative disorders. To determine their exact mechanism of action, further studies are suggested.
Public Perceptions and Willingness-to-Pay for Nanopesticides
Authors: Liu Peiyuan , Zheng Xiaodong , Shangguan Shuangyue , Zhao Lina , Fang Xiangming , Huang Yuxiong , Hermanowicz Slav W.
Published: April 2022

The usage of pesticides is deemed essential to ensure crop production for global food security. Conventional chemical pesticides have significant effects on ecosystems. Nanopesticides are increasingly considered an emerging alternative due to their higher efficiency and lower environmental impacts. However, large knowledge gaps exist in the public perceptions and willingness-to-pay (WTP) for nanopesticides. Thus, we conducted a regional survey of pesticide users and food consumers on perceptions and WTP for nanopesticides across China. We found that 97.4% pesticide users were willing to pay for nanopesticides, with a main price from 25% to 40% higher than for conventional pesticides. Experience with applying pesticides, income, familiarity with and attitude toward nanopesticides, and trust in industries were significant determinants of WTP. Although the public were not familiar with nanopesticides, they had positive attitudes toward their future development and supported labeling nanoscale ingredients on products. Pesticide users presented high trust levels in governments and industries, while 34% of food consumers neutrally or distrusted industries in selling and production. This study highlights the socioeconomic and technological aspects of nanopesticides, which could provide guidance for industries to develop market strategies and for governments to design relevant regulation policies effectively, contributing to crop yield improvement and sustainable agriculture.
Application of Exogenous Iron Alters the Microbial Community Structure and Reduces the Accumulation of Cadmium and Arsenic in Rice (Oryza sativa L.)
Authors: Li Tingting , Li Jiayuan , Zhan Xin , Wang Xueli , He Bing , Cao Feishu , Liao Changjun , Yu Yuefeng , Zhang Zengyu , Zhang Junhui , Li Bei , Chen Jiancheng , Li Hong , Zhu Zhiqiang , Wei Yanyan , Hu Junming
Published: April 2022

Cadmium (Cd) and arsenic (As) contamination of soil has been a public concern due to their potential accumulation risk through the food chain. This study was conducted to investigate the performance of ferrous sulfate (FeSO4) and ferric oxide (Fe2O3) nanoparticle (Nano-Fe) to stabilize the concentrations of Cd and As in paddy soil. Both Fe treatments led to low extractable Cd and the contents of specifically sorbed As contents, increased (p < 0.05) the Shannon index and decreased (p < 0.05) the Simpson diversity indices compared with the control. Nano-Fe increased the relative abundances of Firmicutes and Proteobacteria and decreased the abundances of Acidobacteria and Chloroflexi. Moreover, the addition of both forms of Fe promoted the formation of Fe plaque and decreased the translocation factor index (TFs) root/soil, TFs shoot/root, and TFs grain/shoot of Cd and As. These results suggest that exogenous Fe may modify the microbial community and decrease the soil available Cd and As contents, inhibit the absorption of Cd and As by the roots and decrease the transport of Cd and As in rice grains and the risk intake in humans. These findings demonstrate that soil amendment with exogenous Fe, particularly Nano-Fe, is a potential approach to simultaneously remediate the accumulation of Cd and As from the soil to rice grain systems.
Nutritional and Psychological Considerations for Dietary Therapy in Eosinophilic Esophagitis
Authors: Molina-Infante Javier
Published: April 2022

The step-up empiric elimination diet, starting from one/two food groups of most local allergens remains the current gold standard for a dietary approach in eosinophilic esophagitis (EoE) patients. Milk, followed by wheat and egg, is the most frequent food that triggers EoE in pediatric and adult patients. Elimination diets, with restrictions over four food groups, may be limited to highly motivated patients, in which nutritional counseling is recommended. Malnourishment is uncommon in EoE patients and likely multifactorial (concomitant gastrointestinal eosinophilic disorders or IgE-mediated food allergies, feeding difficulties, abnormal feeding behavior). Avoidant/restrictive food intake disorder in EoE children on highly restrictive diets was lately described and may warrant specific psychological support. As for adults, quality of life may be impaired by symptom severity and dietary restrictions, aside from recently reported food impaction-related specific anxiety in up to 43% of patients. Severe symptoms, feeding dysfunction, and diet restrictions may negatively influence psychosocial adjustment for patients and their caregivers.
Resolution Limit of Correlation Plenoptic Imaging between Arbitrary Planes
Authors: Scattarella Francesco , D’Angelo Milena , Pepe Francesco V.
Published: April 2022

Correlation plenoptic imaging (CPI) is an optical imaging technique based on intensity correlation measurement, which enables detecting, within fundamental physical limits, both the spatial distribution and the direction of light in a scene. This provides the possibility to perform tasks such as three-dimensional reconstruction and refocusing of different planes. Compared with standard plenoptic imaging devices, based on direct intensity measurement, CPI overcomes the problem of the strong trade-off between spatial and directional resolution. Here, we study the resolution limit in a recent development of the technique, called correlation plenoptic imaging between arbitrary planes (CPI-AP). The analysis, based on Gaussian test objects, highlights the main properties of the technique, as compared with standard imaging, and provides an analytical guideline to identify the limits at which an object can be considered resolved.
Eight-Channel LAN WDM (De)Multiplexer Based on Cascaded Mach–Zehnder Interferometer on SOI for 400GbE
Authors: Zhao Zhizun , Li Zhen , Niu Jiaqi , Zhang Gaolu , Chen Hongliang , Fu Xin , Yang Lin
Published: April 2022

In this paper, we design and experimentally demonstrate an eight-channel cascaded Mach–Zehnder interferometer (MZI) based Local Area Network (LAN) Wavelength Division Multiplexing (WDM) (de)multiplexerwith channel spacing of 800 GHz on a silicon-on-insulator. By cascading a three-stage MZI, eight target wavelengths are (de)multiplexed. The length difference of the third-stage MZI delay arms is adjusted so that the output channels skip the guard band. In order to keep the central wavelength of each channel from shifting, we utilize a wide waveguide for the phase delay arm in MZI to achieve large fabrication tolerance, and the multi-mode interference (MMI) couplers as power splitters with weak dispersions. The measurement results of the fabricated device show the precise wavelength alignment over the whole working wavelength range.
A New Type of Etched Fiber Grating Hydrophone
Authors: Liu Wen-Fung , Li Jia-Guan , Chang Hung-Ying , Fu Ming-Yue , Chen Chi-Fang
Published: April 2022

We propose a new type of fiber hydrophone composed of an etched fiber Bragg grating and a special packaging structure for detecting acoustic waves in the low-frequency band under water. The operating mechanism is based on the mechanical vibration of the fiber Bragg grating from the induced vibrating stress of acoustic pressure. The induced pressure of acoustic waves pushes the silicone rubber thin film, causing its vibration and then stretching the fiber Bragg grating, thus resulting in the grating wavelength shift which is overlapped with a tunable laser. The variation in the overlapped light intensity is transferred to an electrical signal by using a photodetector. From the experimental results, we can determine that the smaller the fiber diameter, the higher the sensitivity and frequency response. In order to confirm that this FBG hydrophone has the ability to work in high-frequency acoustic waves, this fiber grating hydrophone and a standard piezoelectric hydrophone are experimentally compared to in the same test conditions in the frequency range from 4 to 10 kHz. According to the experimental results, the fiber grating hydrophone has better responsivity than that of the conventional hydrophone. Due to the unique sensing structure design, this wide-band fiber hydrophone can be useful in long-term continuous monitoring of acoustic waves.
Characterization and Toxicity of Hypoxoside Capped Silver Nanoparticles
Authors: Badeggi Umar M. , Omoruyi Sylvester I. , Ismail Enas , Africa Charlene , Botha Subelia , Hussein Ahmed A.
Published: April 2022

The reducing potential of plant extracts in the green synthesis of nanoparticles has been associated with their phytochemicals. Although pharmacologically inactive, a norlignan diglucoside “hypoxoside” (HP) occurs in large quantities in the extract of Hypoxis hemerocallidea (HE). In this work, HP was isolated from HE where both were used in the biosynthesis of the corresponding silver nanoparticles (HP-AgNPs and HE-AgNPs). The AgNPs were fully characterized using various physicochemical techniques and their antimicrobial and anticancer properties were evaluated. Transmission electron microscopy (TEM) revealed sizes of 24.3 ± 4 nm for the HE-AgNPs and 3.9 ± 1.6 nm for the HP-AgNPs. The HE-AgNPs demonstrated enhanced anti-bactericidal effects on Escherichia coli and Salmonella enterica with a minimum inhibitory concentration (MIC) value of 1.95 µg/mL, competing well with the standard drug. The cytotoxic activity showed that the HE-AgNPs reduced cell viability with an IC50 of 0.81 and 4.0 µg/mL, respectively, for the U87 and U251 cells, while the HP-AgNPs displayed 0.20 and 0.55 µg/mL for both cell lines, respectively. Furthermore, while the HE-AgNPs were selective to U87 alone, the HP-AgNPs were selective to both glioblastoma cells tested. The study demonstrated the ability of a single phytoconstituent (hypoxoside), not only as the chief bioreductant in the extract, but also as a standalone reducing and capping agent, producing ultra-small, spherical, and monodispersed AgNPs with enhanced biological properties.
Exogenous Putrescine Increases Heat Tolerance in Tomato Seedlings by Regulating Chlorophyll Metabolism and Enhancing Antioxidant Defense Efficiency
Authors: Jahan Mohammad Shah , Hasan Md. Mahadi , Alotaibi Fahad S. , Alabdallah Nadiyah M. , Alharbi Basmah M. , Ramadan Khaled M. A. , Bendary Eslam S. A. , Alshehri Dikhnah , Jabborova Dilfuza , Al-Balawi Doha A. , Dessoky Eldessoky S. , Ibrahim Mohamed F. M. , Guo Shirong
Published: April 2022

Crops around the world are facing a diversity of environmental problems, of which high temperatures are proving to be the most serious threat to crops. Polyamine putrescine (Put) acts as a master growth regulator that contributes to optimal plant growth and development and increased stress tolerance. Here, the current study aimed to elucidate how Put functions in regulating chlorophyll (Chl) metabolism, oxidative stress, and antioxidant defense, as well as to characterize the expression of genes related to heat stress in tomato seedlings under such stress. The results revealed that Put treatment significantly attenuates heat-induced damage by promoting biomass production, increasing photosynthetic efficiency, and inhibiting excessive production of oxidative stress markers. Heat stress markedly decreased the Chl content in the tomato leaf and accelerated the leaf yellowing process. However, Put-treated tomato seedlings showed a higher Chl content, which could be associated with the functions of Put in elevating PBGD activity (Chl biosynthesis enzyme) and suppressing the activity of the Chl catabolic enzyme (Chlase and MDCase). Under high-temperature stress, the expression levels of the gene encoding factors involved in Chl biosynthesis and Chl catabolism were significantly down- and upregulated, respectively, and this trend was reversed in Put-treated heat-stressed seedlings. In addition, exogenous application of Put boosted the activity of antioxidant enzymes, along with the levels of expression of their encoding genes, only in plants that were heat stressed. Furthermore, the expression levels of heat-shock-related genes (HSP90, HSP70, and HsfA1) were elevated in Put-treated, high-temperature-stressed tomato seedlings. Taken together, our results indicate that Put treatment significantly increases the heat tolerance of tomato seedlings, by elevating Chl concentrations and suppressing Chl catabolic enzyme activity, modulating endogenous free PA content, increasing antioxidant defense efficiency, and upregulating the expression of heat-shock-related genes.
Combinational Variation Temperature and Soil Water Response of Stomata and Biomass Production in Maize, Millet, Sorghum and Rice
Authors: Khanthavong Phanthasin , Yabuta Shin , Malik Al Imran , Hossain Md Amzad , Akagi Isao , Sakagami Jun-Ichi
Published: April 2022

Environmental responses of stomatal conductance (gs) as basic information for a photosynthesis-transpiration-coupled model have been increasing under global warming. This study identified the impact of gs behavior under different soil water statuses and temperatures in rice, maize, millet, and sorghum. The experiments consisted of various soil moisture statuses from flooding to drying and combination of soil moisture status and temperature. There was a reduction in shoot biomass of maize and sorghum caused by decreasing of gs, photosynthesis (A), and transpiration (E) in early imposed waterlogging without dependent temperature, whereas millet and rice were dependent on temperature variation. The effect of gradual soil drying, gs, A, and E of maize, millet, and sorghum were caused by low temperature, except rice. The impact of the combination of various soil water statuses and temperatures on gs is important for the trade-off between A and E, and consequently shoot biomass. However, we discovered that an ability to sustain gs is essential for photo assimilation and maintaining leaf temperature through evapotranspiration for biomass production, a mechanism of crop avoidance in variable soil water status and temperature.
Reaction Extraction of Levulinic Acid and Formic Acid from Cellulose Deep Hydrolyzate
Authors: Dong Baoshi , Cong Haifeng , Li Xingang , Li Hong , Gao Xin
Published: April 2022

Levulinic acid (LA), a platform chemical with high added value, can be obtained by deep hydrolysis of cellulose, but accompanied by the production of formic acid (FA). Due to its high water content, the recovery of levulinic acid and formic acid from aqueous solution consumes a lot of energy in industry. This paper will use the method of reactive extraction to explore the optimal conditions for the recovery of levulinic acid and formic acid from deep hydrolysate. First, the kinetic and thermodynamic parameters of the reaction process were studied. Then, the effects of different parameters, such as temperature, catalyst dosage, and raw material ratio, on the reaction extraction process were investigated. Finally, through the simulation and optimization of the process, the optimized recovery conditions were chosen to realize the recovery of formic acid and levulinic acid. It is found that reactive extraction can achieve the purpose of efficiently separating levulinic acid and formic acid from the aqueous solution by the yield of 99.1% and 99.9%, respectively.
Drying Biomass with a High Water Content—The Influence of the Final Degree of Drying on the Sizing of Indirect Dryers
Authors: Havlík Jan , Dlouhý Tomáš , Pitel’ Ján
Published: April 2022

This article deals with the influence of the final drying degree of moist biomass used as fuel in a power or CHP plant on indirect dryer sizing. For a description of the drying process, experiments with wet bark containing approx. 50 wt% of water were carried out in a laboratory indirect dryer. A new parameter called drying effectivity was introduced, whose size varies according to the degree of biomass being dried. Its maximum value corresponds to the optimal biomass drying, when the relative size of the indirect dryer to evaporate the required mass of water from the biomass would be smallest. Based on the experimentally determined drying characteristics of wet bark, the optimal drying of 13 wt% of water content was evaluated. If the bark was dried to a lower water content, the required relative size and price of the dryer would increase. Similarly, drying a bark with water content above 31 wt% is not very advantageous because drying effectivity continues to increase rapidly at this stage, and the required relative size of the dryer therefore decreases.
Modern Warfare, Spiritual Health, and the Role of Artificial Intelligence
Authors: Konigsburg Joyce Ann
Published: April 2022

Modern warfare utilizes artificial intelligence (AI) combined with remotely piloted aircraft (RPA) to enhance battlefield strategy and create advantages against adversaries. Military drones extend the range of combat, which limits risks, thereby minimizing casualties and loss of human life. With onboard AI systems, drones provide more data and facilitate rapid decision-making for greater situational awareness during conflicts. Military leaders also theorize that remote missions would be physically, emotionally, and psychologically easier for drone pilots, thus reducing mental health issues that plague fighter pilots. However, the intersection of AI with military drones creates unique situations of stress and trauma. RPA personnel manifest symptoms of post-traumatic stress disorder (PTSD) that adversely affect their spiritual health and well-being.
Spirituality in Primary Care Settings: Addressing the Whole Person through Christian Mindfulness
Authors: Cooper Zach
Published: April 2022

Spirituality is integral to the provision of high-quality health and mental healthcare. Despite this, there is limited research on how to assess and address spiritual determinants of health within primary care settings. Many individuals initiate care within primary care settings, and several will only receive care from their primary care provider. The high prevalence of individuals receiving care within primary care settings coupled with the positive impact spirituality has on health and mental health reveal the need to care for spiritual needs within primary care settings. Integrated care is a model of treatment that addresses the fragmentation of healthcare by assessing and addressing the psychosocial determinants of health within primary care settings. The structure of integrated care models is designed to treat the biological and psychosocial determinants of health and, as a result, provide suitable context for assessing and addressing spirituality in primary care settings. The purpose of this paper is to (1) summarize the efforts to integrate spirituality within primary care (whole person care models), (2) summarize the integrated care efforts to promote psychosocial integration, (3) highlight Christian mindfulness as a potential form of intervention to address spirituality within integrated care models, and (4) operationalize the delivery of Christian mindfulness within a fully integrated care model. The conclusions from the conceptual review include both practice innovation for the assessment and intervention of spirituality in integrated care as well as potential direction for future research to study Christian mindfulness within integrated care settings.
Провокація кримінального правопорушення: порівняльно-правовий аспект
Authors: Каменський Д.
Published: April 2022

У науковій статті здійснено авторську спробу проаналізувати, з позицій юридичної компаративістики, проблематику провокації кримінального правопорушення, спираючись на релевантні законодавчі та правозастосовні джерела в Україні та деяких інших державах.

На підставі активного звернення до попередньої законотворчої роботи та опрацювання відповідного зарубіжного досвіду, спрогнозовані деякі перспективи вдосконалення міжгалузевого інституту провокації. Висвітлено доречні історичні та міжнародні аспекти проблематики, розглянуто позиції американських та європейський авторів щодо визначення ознак та меж допустимості провокації. Показано, що кожна держава намагається винайти свій власний, самобутній підхід до юридичної оцінки правоохоронної провокації.
Rancangan dan Asesmen Sistem Manajemen Risiko PT Rafi Pompa Energi
Authors: Utari Nisya Alviony Dwi , Prasetyo Aries Heru
Published: April 2022

PT Rafi Pompa Energi is a vendor company that was founded in 2017 in the South Jakarta area with relatively low risk management practices and has the potential to result in the company's operational failure. Therefore, the aim of this qualitative research is to design and assess the PT Rafi Pompa Energi Risk Management System using ISO 31000: 2018 guidelines. Based on the assessment that has been carried out, it identifies 31 corporate risks derived from four categories; financial risk, operational risk, strategic risk, and externality risk, with the results showing that 16 risks are high risk, 11 risks are moderate risk, and the remaining 4 risks are low risk. Therefore, it is necessary to have risk treatment plan as soon as possible for assessed corporate risks in order to minimize losses for PT Rafi Pompa Energi.
Rancangan Program Pengembangan SDM Stratejik Berbasis Kompetensi untuk Level Manajer di PT XYZ
Authors: Prabowo Chandra Wihardito , Saragih Eva Hotnaidah
Published: April 2022

PT XYZ, a company in outsourcing business, is in the midst of business model change. This change demands two things from the employees. First, because of the increasing complexity of the intended business process, companies need to improve their employees' capabilities. Second, for the process of change to work well and quickly employees need to be in tune with the core competencies of the company. This thesis focuses on achieving that second demand through employee development strategies and programs at the manager level. Managers have a role as a bridge between top management and staff. This unique position makes the manager role as a lever in the internalization of core competencies. The success of PT XYZ instilling core competencies in managers will determine the success of internalizing core competencies across the company. The success of such internalization will determine the success of business model change which will be the future of the company. This will be the foundation of PT XYZ in doing evolution. This thesis produces the design of the strategic scope and program scope of human resource development based on core competency. The strategic scope ensures human resource development will align with and support the corporate strategy. The program scope designs appropriate development activities to build core competencies, develop ways to evaluate them, and ensure managers can apply these core competencies in their jobs.
Rancangan Strategi Bisnis PT.Pel Berlian Pulau Mandangin Tahun 2021 – 2023
Authors: Rohman Abdur Rohman , Hidayati Aprihatiningrum
Published: April 2022

This thesis discusses about the business strategy design 2021 - 2023 period. The formulation of business strategy is carried out by conducting an external analysis, in order to obtain opportunities and threats that can affect the shipping industry, then formulate the strengths and weaknesses of PT. BPM, then performs the formulation of alternative strategies using internal and external analysis (IE) and the TOWS Matrix. And in order to obtain several alternative strategic options. The last step is choosing a strategy using the Quantitative Strategic Planning Matrix (QSPM).  QSPM analysis shows that the selected strategy for the 2021 - 2023 period is a product development and planning business implementation of the chosen strategy.
Strategi Bisnis Kewirausahaan Sosial ABC Periode 2021-2023
Authors: Hastono Diatrhi , Hidayati Aprihatiningrum
Published: April 2022

ABC is a social enterprise that gives training and coaching for business and management also provide mentoring for orphans to start their own business and acting as the linkage between the market and the orphans’ products. Hence, ABC needs a platform such as marketplace by 2023. To achieve this target, ABC has to build business and functional strategies to make the target comes true. ABC does external analysis by using PESTEL, Porter’s Five Forces, Competitor Profile Matrix, and Decision-Making Process. The internal analysis held by using 7S McKinsey. ABC also analyze any impact and map the stakeholder priority.  Based on all the analysis, the business strategy for 2021 to 2023 was built and named as Strategi BANGUN. For 2021, ABC has to confirm its curriculum and the marketplace concept. In the next year, ABC has to build its management system and gain some external fundings. By the end of 2023, ABC has to launch its own marketplace. These strategies need be supported by the functional strategies to be achieved. If all the business strategies could be achieved, then ABC’s target to have its own marketplace by 2023 will be fulfilled.
Standarisasi dan Perbaikan Proses Bisnis dengan Pendekatan Business Process Improvement Pada Viseworks Studio
Authors: Afif Arkan Muhammad , Prasetyo Aries Heru
Published: April 2022

Viseworks Studio is a pre-startup company running on digital art sector of creative industry that offers complete digital asset for visual branding and utility purpose such as: graphic design, photography, videography, animation, interior and architecture, and interaction design. In a new established company, there is no well-standardized business process that causes business cannot run maximally because it is still exploring what kind of activity that must be done and what must be avoided. With the existence of business process standardization and improvement, hopefully company can run the business effectively, efficently, and be able to create added value for customers. This research contains of qualitative data gathered from interview, experiment, and observation directly to the subject that is focused on the people, process, and technology aspect. The result of business process standardization and improvement are: gain of speed from the machine and waiting time, gain of quality, increase of product variety, and gain of product value. Although there has been an improvement, business process lifecycle must be running over the time to create improvement continuously.
Analisis Model Bisnis Hotel XYZ
Authors: Wisnusanjaya Adhityarama , Munir Ningky Sasanti
Published: April 2022

The growth of tourists to visits Bali area provide bright opportunities for the hotel industri. The intense level of price competition arises due to the large number of hotel developments taking place and the large number of un-used rooms. Hotel XYZ is one of the hotels in Bali with a strategic location. Fierce competition has the effect to difficulty determining the appropriate strategy. This research aims to analyze the business model of Hotel XYZ using Model bisnis kanvas(BMC) and formulate a new strategy for 2021-2022 using PEST (Politic, Economy, Social, Technology), Porter's Five Forces, and TOWS analysis. This research is an applied research using qualitative methods and analysis studies conducted at Hotel XYZ Bali and data collecting through by interviews, observations and literature studies. It was found that Hotel XYZ needs to add some BMC strategies such as maintaining the implementation of they CHSE (Cleanliness, Healthy, Safety, Environmental sustainability), improving ADR (Average Daily Rate) by continuously improving they service and products, renovating rooms to look fresh by changing wallpapers and headboards, sales teams need to more carefully to choose customer segments that earn more revenue than just customer volume. In addition, the need for top management cooperation with all its ranks in order to be dynamic when needed, especially difficult times in hard competition.
Buschke – Fisher – Brauer Keratoderma
Authors: Козин В.М. , Козина Ю.В.
Published: April 2022

Наследственные кератодермии редко встречаются в практике врача-дерматолога и вызывают затруднения при диагностике. Учитывая редкие случаи ладонно-подошвенной кератодермии Бушке – Фишера – Брауэра, авторы приводят описание клинических проявлений, патогистологии образцов, лечения и наблюдения за пациенткой Е.И.В., 49 лет, с жалобами на жемчужные гиперкератотические высыпания в течение 20 лет на коже верхних и нижних конечностей без субъективных ощущений. При необходимости подтверждения точечной кератодермии проводят специальные генетические исследования (α- и γ-адаптин-связывающий белок), ПЦР-исследования на ВПЧ. Терапию пациентке назначают не менее 2 раз в год (системные ретиноиды, ангиопротекторы, применение 5–10%-ной салициловой мази, кремов и мазей на основе мочевины), необходим постоянный уход за кожей кистей и стоп – мыльно-содовые ванночки, использование эмолентов, ношение мягкой, не травмирующей кожу обуви, иногда ношение ортопедической обуви, санаторно-курортное лечение.

Hereditary Buschke – Fisher – Brauer keratoderma is rare in the practice of a dermatologist and causes the diagnostic difficulties. Taking into consideration the rare cases of palmar- plantar Bushke – Fischer – Brauer keratoderma, the authors provide a description of the clinical manifestations, pathology of the samples, treatment and monitoring of the patient E.I.V., 49 years old, with complaints of pearl hyperkeratotic rashes on the upper and lower limbs, without subjective sensations during 20 years.If it is necessary to confirm point keratoderma, special genetic studies (α and γ-adaptin-binding protein), PCR studies on HPV are performed.The patient is prescribed therapy at least 2 times a year (systemic retinoids, angioprotectors, the use of 5–10% salicylic ointments, creams and ointments based on urea), constant care for the skin on the soles of the feet and palms of the hands – soap-soda baths, the use of emollients, wearing soft shoes, that do not cause the damage of the skin, sometimes wearing orthopedic shoes, so as spa treatment.
Analysis of interrelations of individual Psychological Characteristics of Pregnant Women and indices of Psychological Adaptation to Pregnancy
Authors: Василенко Т.Д. , Дремина Т.Ф.
Published: April 2022

В статье представлены результаты корреляционного и регрессионного статистического анализа индивидуально-личностных особенностей беременных женщин и показателей психологической адаптации беременных женщин в зависимости от наличия опыта материнства (позитивного, представленного наличием первого ребенка, и негативного, представленного опытом невынашивания беременности) в контексте жизненного пути личности. В нашем исследовании мы предполагаем, что беременная женщина обладает определенными индивидуально-психологическими особенностями, которые влияют на успешность адаптации к новой жизненной ситуации – беременности.В исследовании приняли участие 159 беременных женщин с различным опытом материнства (ожидающие первого ребенка, ожидающие второго ребенка и женщины, имеющие опыт невынашивания беременности (выкидыш)). Выборку составили беременные женщины, ожидающие первого ребенка, и женщины, имеющие опыт невынашивания беременности (выкидыш), в возрасте 22–27 лет (как нормородящие) и беременные женщины, ожидающие второго ребенка, в возрасте 28–32 года (как позднородящие).Результаты нашего исследования показали, что для беременных женщин с различным опытом материнства характерен специфичный комплекс индивидуально-психологических особенностей, которые помогают нам существенно дополнить представления об адаптации к беременности.

The article presents the results of correlational and regression statistical analysis of individual psychological characteristics of pregnant women and indices of psychological adaptation of pregnant women depending on the experience of motherhood (positive, represented by thepresence of the first child, and negative, represented by the experience of miscarriage) in the context of personality’s life journey. In our study, we suppose that a pregnant woman has certain individual psychological characteristics that have an impact on success of adaptation to a new reality situation – pregnancy. the study included 159 pregnant women with different maternity experience (expecting the first child, expecting the second child, and women with experience of miscarriage (abortion)). the sample consisted of pregnant women, expecting the first child and women with the experience of miscarriage (abortion) at the age of 22–27 years (as normal child bearing), and pregnant women, expecting the second child at the age of 28–32 years (as late child bearing).the results of our study showed that pregnant women with different experience of motherhood are characterized by a specific complex of individual psychological characteristics that help to supplement the view of adaptation to pregnancy fundamentally.
Psychological Factors in the Development of Cardiovascular Diseases at Different stages of Life
Authors: Березина Т.Н.
Published: April 2022

Цель исследования: изучение психологических факторов, влияющих на риск возникновения сердечно-сосудистых заболеваний при разных условиях.Методы исследования: естественный эксперимент, близнецовый метод. Были изучены две выборки испытуемых, соответствующих разным условиям:1) 100 пар монозиготных близнецов, уже завершивших жизненный путь, среди которых было 16 пар, в которых один из близнецов умер от острой формы сердечно-сосудистого заболевания во взрослом возрасте;2) 254 человека старше 70 лет, страдающих хроническим сердечно-сосудистым заболеванием, из которых 15 человек умерли в течение 1 года после обследования. У всех испытуемых были изучены особенности жизненного пути и личности или с помощью анкетирования, или посредством опроса родственников. Результаты: развитие острых форм сердечно-сосудистых заболеваний во взрослом возрасте связано с особенностями поведения типа А (целеволевые качества личности, общительность, наличие детей). Прогрессирование хронического заболевания в пенсионном возрасте усиливали нездоровый образ жизни и вредные привычки. Развитие смертельных форм хронического заболевания в пожилом возрасте: риск усиливался при слишком низком и высоком оптимизме, а развитие целеволевых черт, общительности и карьерные достижения выступали ресурсом, снижающим риск.

Abstractthe aim of the study was to study the psychological factors that affect the risk of cardiovascular disease under different conditions. Research methods: natural experiment, twin method. We studied two samples of subjects corresponding to different conditions: 1) 100 pairs of monozygotic twins who had already completed their life journey, among whom there were 16 pairs in which one of the twins died of an acute form of cardiovascular disease in adulthood, 2) 254 people older 70 years old suffering from chronic cardiovascular disease, of which 15 people died within 1 year after the examination. all subjects examined the characteristics of their life paths and personality either bymeans of questionnaires or by interviewing relatives. Results: the development of acute forms of cardiovascular disease in adulthood is associated with the characteristics of type a behavior (goal-oriented personality traits, sociability, the presence of children). Progression of a chronic disease in retirement age was reinforced by an unhealthy lifestyle and bad habits. the development of fatal forms of a chronic disease in old age: the risk increased with too low and high optimism, and the development of goal-oriented traits, sociability, and career achievements were a resource that reduced risk.
Non-demential Cognitive Disorders in Patients with epilepsy: Current state of the Problem
Authors: Коростий В.И. , Блажина И.Ю.
Published: April 2022

Введение. Изучение когнитивных расстройств вследствие неврологических и психических заболеваний представляет особый интерес в связи с большой распространенностью данной патологии и существенным влиянием на качество жизни пациентов и их социальную адаптацию.Цель. Изучение современного состояния проблемы нарушения когнитивных функций у пациентов, которые страдают эпилепсией, выявление факторов, влияющих на когниции.Материалы и методы. Проведен обзор и теоретический анализ первоисточников и современных научных исследований в области когнитивных нарушений при эпилепсии.Результаты. В данной публикации представлен всесторонний обзор научной литературы по поводу современного состояния проблемы когнитивных нарушений у пациентов, страдающих эпилепсией. Освещены результаты научных исследований в области этиопатогенетических факторов, оказывающих влияние на когнитивные функции.Выводы. Когнитивная дисфункция при эпилепсии является многофакторной по своей сути. Локализация и характер поражения, частота и вид эпилептических припадков, преморбидные характеристики пациентов, аффективные и поведенческие расстройства, характерологические изменения, побочные эффекты противосудорожных препаратов, течение заболевания, гендерные признаки и экзогенные заболевания оказывают влияние и обуславливают возникновение и прогрессирование когнитивного дефицита, который в свою очередь существенно влияет на качество жизни пациентов, их работоспособность и социализацию.

Introduction. the study of cognitive impairment due to neurological and mental illness is of particular interest because of the high prevalence of this pathology and significant impact on the quality of life of patients and their social adaptation.Purpose. the study of current state of the problem of cognitive impairment in patients with epilepsy, identification of factors that affect cognitions.Materials and methods. the review and theoretical analysis of primary sources and modern scientific researches in the field of cognitive impairments in epilepsy was carried out.Results. this publication offers a comprehensive review of scientific literature on the current state of the problem of cognitive impairment in patients with epilepsy. the results of scientific researches in the field of etiopathogenetic factors that influence cognitive functions are presented.Conclusions. Cognitive dysfunction during epilepsy is multifactorial in nature. localization and nature of disorder, frequency and type of epileptic seizures, premorbid characteristics of patients, affective and behavioural disorders, characterological changes, side effects of anticonvulsant drugs, course of the disease, gender characteristics, and exogenous diseases affect and lead to the occurrence and progression of cognitive deficits, which significantly affects the quality of life of patients, their ability to work and socialize.