bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Zingiber Officinale and Propolis supplementation on Hospitalized Covid-19 Patients' Oxygen Saturation
Authors: Yudhani Ratih Dewi , Yuliana Heri Suselo  , Dwi Rahayu  , Jatu Aphridasari  , Hartono Hartono
Published: October 2023

Antiviral, anti-inflammatory, and supportive therapy are required in the Covid-19 management, whilst there is no available specific antiviral for Covid-19 patients. Zingiber officinale and Propolis were reported to suppress the pro-inflammatory cytokines and their safety profiles were considered in several toxicity studies. However, their efficacy in hospitalized Covid-19 patients has not been clarified yet. This study explored the activity of Z. officinale and Propolis in modulating the clinical signs and hematology parameters in hospitalized Covid-19 patients. A total of 22 subjects were divided into a control group (standard therapy), and a treatment group (standard therapy and supplemented with the combination of Z. officinale 500 mg/day and Propolis 1000 mg/day). We analyzed the differences in demographic characteristics, clinical signs, and hematology parameters at pre and post-treatment in both groups. The increased oxygen saturation in control and treatment groups were 0.45 ± 0.45 and 3.45 ± 1.16, respectively (p = 0.011). Moreover, the high-fluorescent lymphocyte count (HFLC) and mean platelet volume (MPV) in the treatment group tend to be lower compared to the control, although it is not statistically significant. The supplementation of Z. officinale and Propolis has beneficial effects in alleviating clinical signs of Covid-19 disease, especially in the enhancement of oxygen saturation, and tend to restore the hematological parameters.
Vitamin D3 and the Molecular Pathway of Skin Aging
Authors: Danimayostu Adeltrudis Adelsa , Martien Ronny , Lukitaningsih Endang , Danarti Retno
Published: October 2023

Many women pay attention to skin aging. Signs of aging such as lines, wrinkles, dry skin, hyperpigmentation, and loss of elasticity affect skin appearance and self-confidence. Age, lifestyle, and particularly UV irradiation stimulate reactive oxygen species (ROS) production. ROS induces the breakdown of collagen through matrix metalloproteinases (MMPs). Collagen and elastin play a pivotal role in skin aging. They maintain skin integrity, strength, and resiliency. Antioxidant and keratolytic agents are often used in anti-aging products, including several vitamins such as vitamin A, B, C and E. To date, several studies have been reported in the literature for the effects of vitamin D on collagen synthesis and MMPs inhibition. This review focuses on identifying and assessing the molecular pathways of vitamin D effects related to skin aging. The literature was collected from Google Scholar, Elsevier, Science Direct, PubMed, and Scopus databases and accessed between January 2019 and May 2022. The literature screening was conducted using keywords like “vitamin D3”, “collagen”, “matrix metalloproteinases”, “skin aging” and related to the study topic were included. The effect of vitamin D3 on MMPs inhibition (particularly on MMP-1, MMP-3, and MMP-9) has been widely published. Several studies have reported that vitamin D increases collagen synthesis and clinically improves skin elasticity. However, there have been controversial results regarding how vitamin D3 affects transforming growth factor-β (TGF-β) correlated with skin elasticity by the molecular pathway. Therefore, it can be concluded that vitamin D3 is a potential alternative agent in improving skin aging.
Alginate-ZnO-Poly(ethylene glycol) dimethacrylate (PEGDMA) via Interpenetrating Polymer Network as a Functional Material for Wound Dressing
Authors: Nurjanah Ane , Amran Muhammad Bachri , Rusnadi Rusnadi
Published: October 2023

Alginate is a biopolymer that has been widely applied as a wound dressing material. To increase the mechanical and antibacterial properties of a wound dressing material, nanoparticles and synthetic polymers are used to modify alginate. One of the materials synthesized into nanoparticles is ZnO, which has potential applications in the medical field because of its good antibacterial properties. On the other hand, PEGDMA has not been widely used in the medical field, opening opportunities to develop research, especially regarding wound dressing materials. However, there has never been a detailed report on the modification of alginate using ZnO and PEGDMA. In this paper, alginate was modified using ZnO and poly(ethylene glycol) dimethacrylate (PEGDMA; alginate–ZnO–PEGDMA, AZP), which was synthesized using the Interpenetrating Polymer Network (IPN) method. AZP can increase a wound dressing material’s mechanical properties by 78% and the antibacterial properties by 94%, which indicates that alginate modification with ZnO and PEGDMA produces high-performance wound dressing materials.
Persistence to Antihypertensive and Clinical Outcomes in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention
Authors: Kristin Erna , Dinarti Lucia Kris , Febrinasari Ratih , Pratiwi Woro Rukmi , Yasmina Alfi , Jaya Sudi Indra
Published: October 2023

Acute coronary syndrome (ACS) is a life-threatening condition that carries a high risk of recurrent cardiovascular events and death. Persistence to treatment is known to reduce disease morbidity and mortality in patients with ACS. In this study, we focus on ACS patients undergoing their first percutaneous coronary intervention (PCI) to investigate the association between persistence to antihypertensive therapy and clinical outcomes. A retrospective cohort study with two years of follow-up was conducted with 367 patients recruited. Patients were deemed as having the persistence to antihypertensive therapy (C02, C03, C07, C08, C09) if the gap between prescriptions was ≤ 30 days. The clinical outcomes are defined as a composite of major adverse cardiac event (MACE), major adverse cardiovascular and cerebrovascular events (MACCE), myocardial infarction, recurrent PCI, stroke, all-cause death, cardiovascular death, and hospitalization. Cumulative persistence to antihypertensive showed 72.3% of ACS patients still taking antihypertensive one year after PCI. Persistence to treatment with antihypertensive therapy can be used as a predictor of MACE or MACCE because it was associated with recurrent PCI (RR 1.94, 95% CI = 1.02-3.71). Our study indicates that among ACS patients undergoing their first PCI, non-persistence to antihypertensive therapy may lead to worse clinical outcomes. This data will be useful to promote secondary prevention in ACS patients after PCI.
Association Of Single Nucleotide Polymorphism With Insertion/Deletion ACE Gene Detected Using RhAmp Platform In COVID-19 And Hypertension Patients
Authors: Faustine Ingrid , Malik Amarila , Andrajati Retnosari , Wanandi Septelia Inawati
Published: October 2023

The high activity of Angiotensin Converting Enzyme (ACE) in patients with hypertension is thought to affect the risk and severity of COVID-19. Insertion/deletion (I/D) and SNP polymorphisms of the ACE gene can affect ACE activity in the Renin-Angiotensin System (RAS). This study aims to identify linkage disequilibrium SNPs rs4331 (A/G), rs4341 (G/C), and rs4343 (G/A) with I/D polymorphisms reported in previous studies and their associations with the severity of COVID-19 with hypertension comorbid. A cross-sectional study in 2021 recruited 95 samples of COVID-19 patients from two regions representing the eastern and western parts of Indonesia. Detection of polymorphisms using rhAmp SNP showed the percentage of genotypes GG, AG, and AA at rs4331 according to genotype II, DI, and DD in polymorphism I/D (57%, 32%, and 11%). In contrast, rs4341 only showed one type of genotype (GG), and 37% of the samples were undetermined at rs4343. Based on the linkage disequilibrium, it is known that rs4331, rs1799752, and rs4343 are in strong LD (D'= 0.97 and 0.99), and rs4331 and rs1799752 can be markers of genes to replace one with another (R2= 0.957). The haplotype analysis showed a significant difference between the residents of western and eastern Indonesia (p = 0.005), whereas this was not the case with hypertension comorbidities and the severity of COVID-19. Seventeen percent of the G-I-G-G haplotypes showed moderate-severe severity, while 15% of the A-D-G-G haplotypes showed mild severity. Therefore, it can be concluded that the high I/D, rs4331, and rs4343 polymorphisms are likely co-inherited and that the G-I-G-G haplotype is associated with moderate-to-severe severity in COVID-19.
A Retrospective Study of Body Weight Changes in Patients Receiving Cyproheptadine in A Hospital-Based Outpatient Setting in Thailand
Authors: Chansane Sirasit , Suntornsantoon Woranat , Chaiyapak Pongpan , Thet Daylia , Siritientong Tippawan
Published: October 2023

Cyproheptadine has been used as an appetite stimulant to increase body weight in various population. This study aimed to determine the effect of cyproheptadine on weight changes in Thai patients. A retrospective longitudinal study was conducted in adult patients who were prescribed with cyproheptadine, having body weight records at 2 times consecutively during 12-month period at the medical outpatient department, the Police General Hospital, Thailand. Of 125 participants, 69.6% were females and the mean age was 78.38 (SD ± 11.68) years. Hypertension, dyslipidemia and diabetes mellitus were the most common underlying conditions. The mean body mass index (BMI) at 1st visit was 21.16 (SD ± 3.64) kg/m2. The mean body weight at 1st and 2nd visit were 52.46 (SD ± 11.11) kg, and 52.61 (SD ± 10.98) kg, respectively. Overall, there was no significant change in body weight between two visits. In underweight patients (BMI < 18.5 kg/m2), the mean BMI decreased significantly in the 2nd visit compared to 1st visit (p = 0.044). At the 2nd visit, older age and high-density lipoprotein cholesterol levels were negatively associated with body weight (p < 0.05). The polypharmacy (odds ratio (OR), 0.778; 95% confidence interval (CI), 0.616 – 0.982), the presence of hypertension (OR, 0.022; 95%. CI, 0.001 – 0.390) and low-density lipoprotein cholesterol levels (OR, 0.969; 95% CI, 0.942 – 0.996) were also negatively associated with abnormal BMI. Cyproheptadine might not improve the body weight of patients in this population. The factors associated with lower body weight in this study may be helpful in further research.
Knowledge and Attitude among Community Pharmacists regarding Pharmacovigilance – A Cross Sectional Survey
Authors: Ghozali MT , Murni Intan Waskita
Published: October 2023

The adverse drug reaction reporting system or pharmacovigilance, as a part of post-marketing surveillance, is the responsibility of every country and national government. Therefore, optimization of knowledge and attitude regarding the system were very essential. This study aimed to examine the relationship between knowledge and attitude regarding pharmacovigilance among pharmacists working in public healthcare services in the rural area. This study was a cross-sectional analytical observational research involving 48 hospital and community pharmacists carried out from July to December 2021 at Bantul Regency, Yogyakarta, Indonesia. Descriptive statistics and frequency distribution analysis were conducted to obtain an overview of knowledge and attitude regarding pharmacovigilance system, while chi-square examined the relationship between them. The results showed that 60.4% of participants had good knowledge, and 52.1% had a positive attitude regarding the system. It was also confirmed that there was a relationship between knowledge and attitude with a p-value of 0.045. Therefore, there was a relationship between knowledge and attitude regarding pharmacovigilance among pharmacists working in rural public healthcare. Based on the results of this study, it was highly recommended for healthcare practitioners, especially pharmacists, to learn and practice pharmacovigilance in their respective practice.
L-proline as co-crystal forming amino acid for enhanced dissolution rate of lamotrigine: Development of buccal tablet
Authors: Abdelrahman Howaida , Essa Ebtesam , El Maghraby Gamal , Arafa Mona
Published: October 2023

Lamotrigine is an antiepileptic drug with slow dissolution rate which can reduce its oral bioavailability. In addition, it was reported to have first pass metabolism. Accordingly, the aim of this work was to enhance its dissolution rate utilizing co-crystallization technique to be suitable for incorporation in buccal dosage form. L-proline was selected as co-crystal co-former for enhancing dissolution in addition to its beneficial anticonvulsant properties. Formulations containing lamotrigine and L-proline at different molar ratios were prepared using ethanol assisted co-grinding. The prepared formulations were characterized using FTIR, X-Ray powder diffraction, differential scanning calorimetry and dissolution studies. The formulation recorded the highest dissolution rate was incorporated in fast disintegrating tablet for buccal use.  Characterization techniques suggested the formation of lamotrigine-l-proline co-crystals with 1:2 molar ratio being optimum for interaction. This interaction resulted in significant enhancement in dissolution rate with the ratio of lamotrigine to proline at molar ratio of 1:4 showed greatest dissolution rate (% DE= 80.57). The prepared tablet utilizing lamotrigine and L-proline at molar ratio of 1:4 showed fast disintegration and rapid dissolution rate compared with control tablet containing lamotrigine alone. The study suggested L-proline as an efficient co-crystal co-former for enhancing dissolution rate of lamotrigine for buccal delivery.
LC-HRMS Metabolite Profiling of Lunasia amara Stem Bark and In Silico Study in Breast Cancer Receptors
Authors: Agus Saputra  , Ietje Wientarsih  , Mohamad Rafi  , Lina Noviyanti Sutardi  , Silmi Mariya
Published: October 2023

L. amara is a medicinal plant used as an aphrodisiac. Several studies show it has a compound with biological activities such as inhibition of cell proliferation, one of the mechanisms leading to anticancer activities. This study aimed to profile the metabolites and predict activity against two breast cancer receptors (ERα (3ERT) and HER2 (3PPO)) with an in silico approach. Metabolite profiling of water and 80% ethanol extract was analyzed by UHPLC-Q-Orbitrap-HRMS. Also, we performed a radical scavenging activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH). Putative identification of metabolite in L. amara showed the 46 metabolites (4 unknown) were identified and predominantly as quinoline alkaloids. Some of the compounds from glycosides and phenol groups were also identified. From the antioxidant capacity test results, the 80% ethanol extract had a higher radical scavenging capacity than the aqueous extract. Based on the molecular docking results, the highest affinity for the ERα receptor was found in the tested compound tetrahydropapaveroline and exceeded the native 4-OHT ligand. For the HER2 receptor, graveolinine has the highest affinity but is still below the native lapatinib ligand. Ligand interactions with the amino acids Leu 387 and Glu 419 on the active site of the ERα receptor and Phe1004 on the HER2 receptor are thought to play an important role in increasing the energy affinity. Overall, all compounds showed higher affinity for HER2 receptors than ERα. Alkaloids demonstrated anticancer activity. Further research should be conducted to determine the in vitro activity of these compounds on breast cancer cells.
Effectiveness of Dry Grinding and Wet Grinding Methods on Solution and Dissolution Rate of Nimodipine-HPMC Nanoparticles
Authors: Fadhila Muthia
Published: October 2023

Nimodipine is a dihydropyridine calcium channel blocker that shares the general properties of nifedipine, but acts mainly on cerebral blood vessels. Nimodipine belongs to the Class II Biopharmaceutical Classification System (BCS) drug group, which has low solubility and high permeability. The purpose of this study was to look at the differences in the yield of nanoparticles between the dry grinding and wet grinding methods on the physicochemical properties, solubility, and dissolution rate of nimodipine nanoparticles. The nanoparticles were prepared a nimodipine: HPMC ratio of 1:0.6 using two different methods. Sample characterization was carried out using Particle Size Analyzer (PSA), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-ray Diffraction (XRD), and Fourier Transform Infrared (FT-IR). The Solubility test was carried out in CO2-free distilled water and the dissolution rate was carried out in phosphate buffer pH 7.2. The solubility of pure nimodipine in CO2-free distilled water was 0.339 µg/mL, the physical mixture was 1.948 µg/mL, the dry grinding nanoparticles were 3.367 µg/mL, and the wet grinding nanoparticles were 19.952 µg/mL. The dissolution test results obtained with the percentage of pure nimodipine dissolution at 60th minutes was 33.947%, the physical mixture was 39.482%, the dry grinding nanoparticles were 49.798%, and the wet grinding nanoparticles were 56.484%. Based on the results of the study, it can be said that the nimodipine-HPMC nanoparticles significantly increased the solubility and dissolution rate of nimodipine.
Isolation and Characterization of Curcumenotone, a Sesquiterpene from Curcuma aeruginosa Roxb as Antioxidant
Authors: Suharsanti Ririn , Wahyuono Subagus , Astuti Puji , Yuniarti Nunung
Published: October 2023

Antioxidant compounds are necessary to block the initiation of oxidation chain reactions and inhibit the formation of ROS which are the cause of various diseases. Natural antioxidants can be isolated from various sources, one of them from Curcuma aeruginosa Roxb Rhizome. This study was aimed to isolate and identify antioxidant compounds from Curcuma aeruginosa Roxb rhizome. To isolate the active compound, the 2,2-diphenyl-1-picrylhidrazyl (DPPH) free radical scavenging activity guide was used. Initially the Curcuma aeruginosa Roxb rhizome powdered material macerated with ethanol 70% to give ethanol extract (EE). The EE was then fractionated gradually with increasing polarity solvents to give n-hexane (HF), ethyl acetate (EAF), ethanol (EF) and insoluble (IF) fractions. The EF was the active fraction, was fractionated  into 6 fractions (EE.a-f)  based on their TLC picture. Two compounds (EF.a1 and EF.a2)  were isolated from active fraction (EF.a) by preparative TLC. The EF.a2 appeared as white crystals demonstrates better activity as anti radical DPPH, having 96.24% purity (HPLC). EF.a2 appeared as a single peak in GC (Rt 12,78), and having molecular weight at m/z 234. There were 2 absorbtion peaks at 226 nm and 260 nm in Uv-Vis spectrophotometer and absorption bands at 3364, 3314, 2905 and 1653 cm-1 on the FT-IR spectrum. Based on spectroscopic data (1H-,13C-NMR) and comparison with reported data, the EF.a2 was identified as sesquiterpene, curcumenotone (C15H22O2). The curcumenotone was shown potent antioxidant in DPPH radical scavenging assay had an IC50 53.24±1.51 µg/mL, ABTS radical scavenging assay had an IC50 41.33±3.15 µg/mL, and FRAP assay had an IC50 37,82±2.02 µg/mL.
Geigeria alata- a potential source for anti-Alzheimer’s constituents: In vitro and computational investigations
Authors: Osman Wadah , Maaz Mohamed A. , Ali Amna , Eltayeb Fadul  , Ahmed H. Arbab  , Mosab Yahya Al-Nour  , Ahmed Ashour  , Asmaa E. Sherif  , Hamada S. Abulkhair  , Ibrahim Sabrin R.M , Kholoud F. Ghazawi  , Gamal A. Mohamed  , Mona S. Mohamed
Published: October 2023

Antioxidants and acetylcholinesterase inhibitors play a key role in the prevention and management of degenerative disorders including Alzheimer’s disease in particular. Identifying new anticholinesterases from natural sources may contribute to combating this class of diseases. The present study aimed to evaluate the potential anti-Alzheimer’s activity of Geigeria alata (DC), a plant used in Sudanese folkloric medicine. Accordingly, the whole DC plant extract including twenty phytoconstituents of phenolic, flavonoid, and tannin types was evaluated in vitro as antioxidants and acetylcholinesterase inhibitors. As well, their pharmacokinetics, drug likeliness, and toxicity profiles were assessed. Additionally, the virtual binding of the plant’s phytoconstituents with the cholinesterase target was investigated by docking against two AChE X-ray crystallographic structures. The best effective DPPH radical scavenging activity was demonstrated by both ethyl acetate and n-butanol fractions with percentages of inhibition of 91 ± 0.02% and 90 ± 0.02% (IC50 22 ± 0.01 and 66 ± 0.02 µg/mL), respectively. The ethyl acetate fraction showed statistically significant, and the highest AChE inhibitory activity (78% inhibition, IC50 0.246 ± 0.02 mg/mL). Furthermore, the ethyl acetate fraction exhibited the highest total phenolic, flavonoid, and tannin values. Among identified compounds, quercetin and hispidulin showed promising in silico anti-AChE activity and hence merit further studies for the isolation and characterization of these active constituents.
Challenges in Achieving Optimal Warfarin Anticoagulation Control: A Comprehensive Exploration and Proposed Holistic Approaches
Authors: Nilamsari Wenny Putri , Hamdani Indri Yuliani , Suprapti Budi , Assegaf Mochammad Yusuf , Yogiarto Mohammad , Suharjono
Published: October 2023

In Indonesia warfarin remains the most widely oral anticoagulation prescribed. However, the time in therapeutic range remain low in Indonesia and also in some countries in throughout the world. This study aimed to analyse the challenges of optimal warfarin control from the perspectives of healthcare professionals, patients, health system, and to propose strategies to address these challenges. This research consists of two stages. The first stage was a prospective observational study aiming to analyse the challenges and the second stage of the research was focus group discussion to propose strategies to overcome the challenges. The result of this study showed that the average of TTR was 49.4 ± 32.1, where only 37.5% patients had TTR ≥ 65%. The average dosing consistency obtained was 62.33 ± 32.42%. With regard to INR monitoring interval, almost all patient who had supraterapeutic INR had their INR monitoring interval set to 1 month after the dose adjustment. There were also identified that only 43.8% patients classified as adherent and only 39.5 % patients had good knowledge of warfarin, indicating that the level of medication adherence and knowledge was not optimal. In this study, 14.6% of patients received other drugs that potentially interacted with warfarin that cause fluctuate INR. In conclusion, this study's results showed that there were multiple challenges for optimal warfarin control including barrier for dosing consistency, INR monitoring, patients’ adherence and knowledge, as well as drug interactions. However, there will be still room for improvement. The proposed strategy that likely will achieve optimal benefit was a holistic approach that combine multifaceted strategies to address each barrier.
Penanganan Kesehatan Jiwa di Jakarta, 1960-an–1970-an
Authors: Negoro Mustaqim Aji
Published: October 2023

This study examines the development of mental health management in Jakarta between the 1960s and 1970s. The discussion focuses on the question of how the process of expanding mental health services in Jakarta in the 1960s to 1970s took place. This is important because it has been in these years that awareness – both from the government and the private sector – emerged and developed rapidly in Jakarta. The majority of sources used in this paper are news in contemporary newspapers and magazines. Through this search, historical facts regarding the handling of mental health in Jakarta are collected and arranged chronologically.
Gerakan Agraria di Tapanuli Utara Awal Orde Baru (1971–1979)
Authors: Sinurat Lasron P.
Published: October 2023

Under the New Order government, the control of agrarian resources by the state was a way to ensure development programs that increased the country's economic income. This control is legitimized by agrarian political policies, including management through Law no. 5 of 1967 concerning the Basic Provisions of Forestry. In North Tapanuli, expanding the state forest area as mandated by the Forestry Law is a new chapter in the struggle for land rights, and triggers the emergence of community resistance movements. This article will discuss the history of the agrarian movement in North Tapanuli in 1971-1979. People's resistance signifies the inaccuracy of rural communities in the development of the country.
Science and Literature: Distances and Approaches
Authors: Santos Geraldo Mendes dos , Medri Moacyr Eurípedes
Published: October 2023

The Academy and other formal institutions that deal with knowledge tend to treat Science and Literature as distinct areas, each with very particular ways and methods of building knowledge. However, in certain aspects—perhaps the most important—both carry and disseminate their messages through the same symbolism and vehicle of communication, that is, the word. Both Science and Literature are useful, beautiful and edifying mechanisms, which can be used by the same person, in the same context or creative process, thanks to the proliferation of communication technologies, especially books, magazines, articles, computers and smartphones. In other words: these two segments are continuous or complementary, since all Sciences and technologies refer to reality, and this, in a broad sense, is an indivisible unit. This means that arbitrary divisions of knowledge help in the effort to organize studies, research and their products, but the established division is always compulsory and alienating, hence the urgent need for true interdisciplinary, considering that knowledge is one, with a universalizing character. This article aims to analyze the intricacies of these two areas of knowledge, drawing parallels between their construction processes and verifying the reasons for their distances and approaches over time.
Representation of cities as spaces through symbolist imagery in T.S. Eliot’s The Wasteland and Arun Kolatkar’s Kala Ghoda
Authors: Parmar Amisha
Published: October 2023

In twentieth-century's poetry, the city has become an important and complex theme because when writing about cities, poets tend to re-formulate and re-define their relation with literary and cultural traditions. The city poses a particular challenge for the modern poets because of their commitment to social and cultural traditions they feel that their role has been fused to simply responding to the social, moral, cultural and psychological transformations that the city symbolizes. Is it right to read a poet, or poetry, as an extension of a place? The answer is may or may not be. The question is to answer the unique narrative description of Bombay in Arun Kolatkar’s Kala Ghoda and the city of London in T.S. Eliot’s The Wasteland that defines the city using imagery and symbolism in the best manner. Walking through Bombay and reading Kala Ghoda Poems recreates a city that is constantly shifting and dancing around, full of noises and colours, all the while exposing those lives that are pushed out of an expanding concrete jungle, hidden under bright lights and tall towers—the triumphs of development. Eliot utilises the ‘unreal city’ London as the main setting for The Wasteland and the city comes to embody the title of the poem that id portrayed as ugly, cruel and grey, lacking any real human warmth or meaningful connections. The study will be centred on a reading and analysis of deconstructive poetry to show how postmodernism is hinted at while also demonstrating continuous sociocultural and socioreligious activities through the use of symbolism and imagery. The study will continue with chapters broken down into many aspects, including a comparative analysis of Eliot and Kolatkar's poetry, studying the issue of experimentalism and symbolism as well as imagery employed in Kolatkar's Kala Ghoda and Eliot's Wasteland. The subjectivities and experimentation in Indian English poetry and Western poetry can be understood and explored through a comparison of Arun Kolatkar and T.S. Eliot.
Improve Operational Efficiency at Cam Thuy District Culture, Information, Sports and Tourism Center, Thanh Hoa Province
Authors: Loan M.A. Le Thi Thanh
Published: October 2023

In 2019, the Center for Culture, Information, Sports and Tourism of Cam Thuy district was established by reorganizing public service units under the People's Committees of districts and towns—communes and cities operating in the fields of Culture, Sports, Tourism, Radio and Television. After nearly five years of operation, the Center has overcome some difficulties due to the merger and exceeded the tasks and goals compared to the plans set out for each year. However, in the current period, the development of the Center in the coming time will still be complex due to the old-fashioned way of thinking; the Center's activities are solitary, and cultural propaganda work needs to be coordinated. Change and attraction service activities have yet to be focused on. Therefore, studying the limitations in the Center's operations and proposing several solutions to improve the Center's operational efficiency in the future is necessary.
Благопожелание чаю в современной калмыцкой лирике: фольклорный аспект
Authors:   Kalmyk Scientific Center of the RAS (8, Ilishkin St., 358000 Elista, Russian Federation), Khaninova Rimma M.
Published: October 2023

Introduction. The article examines the genre of tea well-wishes in contemporary Kalmyk lyric poetry through the prism of folklore tradition. The fact that the theme has been somewhat understudied from the latter perspective makes the work relevant enough. Goals. The article aims to investigate the folklore aspect in Kalmyk poets’ narratives addressing Kalmyk tea. Materials and methods. The paper analyzes related Kalmyk- and Russian-language poems by contemporary Kalmyk poets representing different generations. The study shall examine a number of folklore genres, such as tea well-wishes, proverbs, sayings, and three-part (ternary) poems. The main methods employed are historical-literary, historical-functional, comparative analysis ones, and that of descriptive poetics. Results. In modern Kalmyk lyric poetry, the mentioned genre is represented by a number of poems dealing with ethnic foods. These are texts in Kalmyk and Russian created by poets of different generations — elderly and young ones. In terms of genre, literary tea well-wishes — like the latter’s folklore analogues — largely tend to synthesize different patterns: these often resemble yöräls (well-wishes) and magtals (praises), sometimes — tea well-wishes proper (Kalm. цәәд тәвх йөрәл) and farewell well-wishes (Kalm. хаалhин йөрәл). Conclusions. Tea well-wishes authored by Kalmyk poets describe offerings to ancestors, deities, as well as treats to guests, which reveals the primacy and undeniable significance of tea in rituals, rites, and hospitality. In the folklore tradition, representative texts addressing Kalmyk tea have been created mainly by elderly and middle-aged poets fluent in mother tongue, familiar with oral folklore, customs, rituals, and beliefs of ancestors.
Историческая фонетика бурятского языка в русскоязычной документации XVII в. (к постановке проблемы). Часть 2
Authors:   Institute for Mongolian, Buddhist and Tibetan Studies, Siberian Branch of the RAS (6, Sakhyanova St., 670047 Ulan-Ude, Russian Federation), Tishin Vladimir V. , Nanzatov Bair Z. ,   Banzarov Buryat State University, Institute of Oriental Studies, Department of Central Asia Philology (24A, Smolin St., 670000 Ulan-Ude, Russian Federation)
Published: October 2023

Introduction. It is in the mid-to-late 18th century at latest that the main phonetic characteristics of Buryat that distinguish the latter from other Mongolic languages — reflected in its western and eastern dialects — took shape. The initial period that had witnessed the formation of these specific elements still remains somewhat unclear. The paper analyzes authentic sources and attempts to show a possibility that the areal phonetic features of Buryat emerged within local population groups of Baikalia as far back as the early-to-mid 17th century. Goals. The article analyzes ethnonyms (and other onyms) relating to the Buryat population and recorded in seventeenth-century Russian-language documents to identify spelling (pronunciation) specificities characteristic of Buryat dialects. Materials and methods. The study examines ethnonyms and personal onyms across Buryat-related historical communities contained in seventeenth-century documents (Rus. otpiski) of Russian servicemen and Cossacks. The work focuses on names traced in two territorial groups of the Buryat population on different banks of the Angara River conventionally be referred to as ‘right-bank Angara territorial group’ and ‘left-bank Angara territorial group’ — regardless of any dialect classification. Results. The conducted analysis attests to that the mentioned period was already characterized by the existence of certain spelling (pronunciation) features within the two identified territorial groups of the Buryat population, the ones to reflect different stages in the development of the Buryat phonetic system. Conclusions. The revealed possibility implying the phonetic features of the Buryat language inherent to different stages of the latter’s development could have already existed as early as the mid-17th century in the population of two wide territorial areas of Baikalia makes it appropriate to outline further prospects of linguistic research to detail developmental chronologies for those phonetic characteristics that eventually led to the shaping of specific features in present-day Buryat.
Exploring Perceived Course Load and Learning Implications in the Context of Online Classes by College Students
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yun Ga-young , Kim Suyoun
Published: October 2023

Objectives This study aimed to explore the perceived course load and learning implications among college students within the context of online classes.
Methods To accomplish this goal, we conducted written interviews via an online platform with 23 college students who had experience with online classes. The collected data were analyzed using thematic analysis methods. Through this process, we extracted and elucidated the factors influencing college students’ course load in online classes and its impact on learning.
Results The study identified four main categories and fifteen themes related to course load. These categories included learner characteristics, instructor characteristics, class activities and assessments, and the inherent characteristics of the online environment. The findings revealed that these factors had both positive and negative effects. Positive effects included increased investment of time in learning and class participation, while negative effects included decreased concentration during class and increased fatigue.
Conclusions The findings of this study provide valuable insights for instructors in designing appropriate instructional elements and support strategies for online classes.
The mediating effect of parenting stress in the effect of fathers' work-family compatibility on subjective happiness
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee SeonMi , Chung Hyejeong , Joo SooKyung
Published: October 2023

Objectives The purposes of this study the benefits and conflicts of fathers' work-family compatibility on subjective happiness and parenting stress were identified, and the mediating effect of parenting stress was verified in these relationships.
Methods To this end, data from the 13th year of the Korean Children's Panel of the Child Care Policy Research Institute were used, and 1,170 working fathers who participated in the survey were studied. SPSS 23.0 was used for data analysis, and a three-stage multiple regression analysis by Baron & Kenny (1986) was conducted to verify the mediating effect of parenting stress.
Results The results of this study are as follows. First, it was found that there was a significant relationship between the father's work-family balance, parenting stress, and subjective happiness. The higher the work-family compatibility advantage, the lower the parenting stress and the higher the work-family compatibility conflict, the higher the parenting stress and the lower the subjective happiness. Second, it was found that parenting stress plays a partial mediating role as a result of examining the mediating effect of parenting stress in the effect of the father's work-family balance advantage on subjective happiness. Third, as a result of examining the mediating effect of parenting stress in the effect of the father's work-family balance conflict on subjective happiness, it was found that parenting stress plays a partial mediating role.
Conclusions The results of this study verified that the benefits and conflicts perceived by fathers while doing work-family compatibility affect subjective happiness, and found that parenting stress also plays a role as a mediator in subjective happiness. Therefore, it is necessary to continuously operate programs such as psychological support and father education to reduce conflicts and parenting stress caused by fathers' work-family balance, and to change social members' perceptions along with policy promotion.
The Structural Relationship between the Need to Explore Community Culture and University Life Adaptation and the Intention to Drop Out: A Multi-group Analysis based on the Experience of Exploring Community Culture for Early Childhood Education Department Freshmen
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Jinok Susanna , Han Jin Wook , Jo Hyeyoung
Published: October 2023

Objectives The purpose of this study is to find out the structural relationship between the need to explore community culture for early childhood education department freshmen and university life adaptation and the intention to drop out intention, and to analyze it in a multi-group analysis based on the experience of exploring community culture.
Methods The subjects of the study are 240 freshmen who entered the Department of Early Childhood Education in Gyeonggi-do, Chungcheong-do, Jeolla-do, and Gyeongsang-do. The directionality and normality of the research variables were validated using SPSS 23.0 and AMOS 25.0 programs. The structural relationship between variables was analyzed by the suitability of the structural model and path coefficient using structural equations. The differences between groups were verified by multi-group analysis after the test of homogeneity.
Results Main findings are as follows. First, the normality of the research variables was confirmed, and the mean of the intention to drop out midway was low. However, the perceived need for exploring the local community culture and adapting to university life, as well as the sub-domains of academic adjustment, social adjustment, and personal-emotional adjustment, was generally high. Second, the intention to drop out showed statistically significant negative correlation with the need to explore community culture, university life adaptation and sub-areas, academic adaptation, social adaptation, personal-emotional adaptation. Third, it was found that the need to explore community culture directly and indirectly affects the intention to drop out, and directly affects the university life adaptation. The results of this study can be interpreted as university life adaptation partially mediates in the process of the need to explore community culture affecting the intention to drop out. Fourth, as a result of multi-group analysis, in the cases of students with experience in exploring community culture, the need to explore community culture had had a greater impact on university life adaptation than those who did not.
Conclusions The results of this study confirm the importance of exploring community culture experience and suggest the direction for the internalization for the program. In addition, I would like to suggest a way to stably operate the extracurricular program suitable for the characteristics of each university and department.
A Study on the Development of Rhythm Creation Class Using Body Percussion: Focusing on Korean Traditional Music Classes in Middle School
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Park Eunjoo , Chu Sunghee
Published: October 2023

Objectives The purpose of this study is to develop rhythm creation classes using physical percussion instruments, focusing on middle school Korean traditional music classes.
Methods To this end, the contents of creation were examined, focusing on the music curriculum revised in 2015 and 2022, and the necessity and significance of research were derived by reviewing previous domestic and foreign studies. In addition, eight middle school music textbooks were selected to explore educational elements and sanctions that meet the purpose and purpose of the study.
Results Based on the necessity and purpose of creative classes using Korean traditional music elements, the rhythm creation class sanctions using body percussion instruments was selected as  which plays as a Danmori rhythm, and a total of two session creative classes were sought. The class model was based on Dale's ‘Cone of Experience’ principle, and a class was developed to promote learners' creativity and community through creative and group activities.
Conclusions This study has the nature of a preliminary study to propose a rhythm creation class that can be realized in the field at a time when creative activities are emphasized in the music and curriculum. In the future, based on this class model, it is expected that a practical approach for effectiveness verification will be made through follow-up studies.
The effect of the elderly's participation in social activities on depression: Focusing on differences in family type and age group
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, koo Kyoung-chin
Published: October 2023

Objectives The purpose of this study is to examine the effect of the elderly's participation in social activities on depression and to identify the difference between family types and age groups in the relationship between participation in social activities and depression.
Methods The subjects of the study were 9,920 elderly people who participated in the survey on the status of the elderly (2020). The analysis method analyzed the collected data through multiple regression analysis and Chow test using SPSS 22.0.
Results The results of the study are as follows. First, economic and leisure cultural activities were found to have a negative effect on depression in the elderly's participation in social activities. Second, the difference in age groups was significant in the relationship between social activities and depression of the elderly. In participation in social activities, it was found that the late elderly had more negative effects on both economic activities and leisure and cultural activities than the early elderly. Third, the difference in family types was significant in the relationship between the elderly's participation in social activities and depression. In participation in social activities, there were more significant negative differences in economic activities for the elderly living alone than for the elderly living alone, and there were more significant negative differences in leisure and cultural activities for the elderly living alone than for the elderly living alone.
Conclusions Based on the above research results, practical measures according to family type and age group were proposed as a way to revitalize the elderly's participation in social activities to prevent depression in the elderly.
The moderating effect of deliberate rumination on the correlation between self-examination and post-traumatic growth in adults over the age of 20 who experienced traumatic events
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Mijeong , Choi Boyoung
Published: October 2023

Objectives This study aims to examine the moderating effect of deliberate rumination on the correlation between self-examination and post-traumatic growth in adults over the age of 20 who have experienced traumatic events.
Methods To achieve this goal, a nationwide online survey was conducted with 300 adults over the age of 20 who had experienced traumatic events, and the survey included self-examination, deliberate rumination, and posttraumatic growth scales. A total of 300 responses were analyzed using hierarchical regression analysis with SPSS 22 to confirm the moderating effect.
Results The results of the study showed that there was a significant positive relationship between self-examination and post-traumatic growth. Additionally, the moderating effect of deliberate rumination on the correlation between self-examination and post-traumatic growth was confirmed. In case of the high-degree of self-examination, the influence of deliberate rumination appeared to be marginal. Conversely, in contexts of limited self-examination, an uptick in deliberate rumination corresponded with a marked rise in post-traumatic growth.
Conclusions When self-examination is low, deliberate rumination can serve as a cognitive processing method that focuses on understanding and re-evaluating the cause and meaning of the traumatic event. It aids in concretizing the impact of the event on oneself and encourages viewing the traumatic event from an objective perspective, identifying its positive aspects. This approach can potentially enhance post-traumatic growth. The implications of the study and suggestions for counseling intervention were discussed.
A Study on Synonyms ‘붓다’ (to pour) and ‘쏟다’ (to spill) using Corpus Analysis: Focusing on the co-occurrence relationship
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Ahn Hyunsoo , Shin Jiwon
Published: October 2023

Objectives This study aims to provide foundational insights for effective instruction and learning by examining the synonymous verbs ‘붓다 (to pour)’ and ‘쏟다 (to spill)’. The research focuses on analyzing the co-occurring words and semantic relationships within a corpus and visualizing the results through language networks.
Methods Based on the examination of vocabulary usage in everyday conversation and spoken corpora of native Korean speakers, as well as the investigation of co-occuring words found in Korean language learner corpora, the semantic relationship and specific patterns of usage for ‘붓다’ (to pour) and ‘쏟다’ (to spill) were explored and visualized through language network analysis.
Results The results of this study are as follows: while native Korean speakers use various extended meanings of ‘붓다’ (to pour) and ‘쏟다’ (to spill), Korean language learners tend to rely on a limited set of co-occuring words provided in Korean textbooks. It indicates an insufficient understanding of the expanded meanings of these synonyms among learners. Additionally, even intermediate and advanced Korean learners have been found to lack a comprehensive understanding of the co-occuring words of ‘붓다 (to pour)’ and ‘쏟다 (to spill)’, leading them to mistakenly interchange the two terms.
Conclusions This study employs componential analysis to examine the distinctive characteristics of semantic relationships through the co-occurring words of ‘붓다 (to pour)’ and ‘쏟다 (to spill)’. Furthermore, we propose a suggested order of presenting meanings and representative co-occurring words for Korean language learners at different proficiency levels.