bluuebunny/crossref_metadata_2025 huggingface dataset:
Tratamiento de aguas residuales domésticas en humedal del Barrio Santiaguito, Texcoco de Mora, México
Authors: Hernández Alonso Beatriz , Corlay-Chee Langen , Morales-Hernández Erica , Vázquez´-Cervantes Santos , Hernández-Tapia Alejandro , Chamizo-Checa Angelina
Published: April 2024

Para el tratamiento de las aguas residuales se pueden emplear métodos físicos, químicos o biológicos. Los humedales artificiales son sistemas construidos específicamente para el tratamiento de las aguas residuales creando un panorama similar a las funciones de los humedales naturales, optimizando los procesos que permite la remoción de los contaminantes. El objetivo de este trabajo fue determinar la eficiencia del humedal del Barrio Santiaguito, localizado en Texcoco de Mora, México y la calidad del agua tratada de acuerdo a los indicadores establecidos por las NOM-001-SEMARNAT-2021 y NOM-003-SEMARNAT-1997, con la finalidad de proponer alternativas para mejorar los procesos de tratamiento. Se obtuvieron eficiencias en remoción de 100 % para bacterias coliformes totales (CT) y fecales (CF), 57.7 % en Demanda Química de Oxígeno (DQO) y Demanda Bioquímica de Oxígeno (DBO5), 98.47 % en sólidos sedimentables (SS), 60.25 % en nitrógeno total y solo 22.92 % para sólidos suspendidos totales (SST). Por lo anterior, se concluye que existe restricción por SST en la descarga de las aguas residuales tratadas, por lo que se proponen como alternativas para mejorar los procesos de tratamiento, el reducir el número de especies vegetales presentes y darles mantenimiento mediante podas periódicas, así como lavado o cambio de material filtrante y dar seguimiento a la eficiencia del humedal mediante muestreos en diferentes horarios y épocas del año.
Estimación de la energía de uso final consumida durante la extracción y aserrado de la madera
Authors: Meza-López Pedro , Nájera-Luna Juan A. , Cruz-Carrera Ricardo de la
Published: April 2024

Introducción: La actividad forestal enfrenta desafíos energéticos que implican la determinación precisa del uso final de energía para lograr mejoras en su rendimiento.Objetivo: Estimar la cantidad de energía de uso final consumida durante el procesamiento de los recursos forestales maderables.Materiales y métodos: El consumo final total de energía (CFT) se determinó en seis empresas (unidades estadísticas) de transformación primaria de la madera en Pueblo Nuevo, Durango. Los datos de actividad y los usos significativos de la energía (USEn), correspondientes a dos años, se obtuvieron mediante una auditoría energética. Los datos se desagregaron por unidad estadística, actividad, forma y aplicación de la energía y se expresaron en toneladas equivalentes de petróleo (tep).Resultados y discusión: El consumo de energía por unidad estadística se estimó en 71.19 tep·año-1, liberando 260.14 tCO2e·año-1. El USEn se identificó en vehículos con motor de diésel (75 %). El uso de gasolina y energía eléctrica en máquinas correspondió al 14.2 % y 10.7 %, respectivamente. Los motores utilizaron hasta 98 % de la energía eléctrica. La extracción de madera ocupó 69 % del CFT, más del doble que el aserrado de madera. El consumo de energía fue significativamente diferente entre unidades estadísticas (Tukey, P < 0.05) durante el aserrado, pero no en la extracción de madera.Conclusiones: El consumo de energía en la actividad de extracción de madera fue similar entre las unidades estudiadas, pero no en la etapa de aserrado. Un programa efectivo de gestión de la energía y la integración de la dendroenergía podría optimizar el modelo de consumo.
Cadena de valor y comercialización de la raicilla en el municipio de Mascota, Jalisco
Authors: Nava-Cárdenas Jade Quetzal , Palacios Rangel María Isabel , Ocampo-Ledesma Jorge Gustavo , Aguilar-Ávila Jorge , Ortiz-Martínez Germán
Published: April 2024

La Raicilla es una bebida artesanal análoga al mezcal, que se produce a partir de la destilación de agave. El objetivo de este trabajo es describir la estructura y organización de la cadena de valor de la raicilla producida en la Sierra Occidental de Jalisco, para mostrar los cambios en la producción y organización de los raicilleros en una línea de tiempo. La pregunta a responder es: ¿Cuáles son las características de la cadena de valor de la Raicilla? Se realizaron encuestas a los productores y se efectuaron entrevistas con actores clave. Se observó que la mayoría de los productores ingresan al mercado a través de una estructura vertical, y un número importante de ellos vende su producto en canales de ciclo corto. Se enfrentan a problemas como la escasez de materia prima, limitada formación técnica y falta de innovación en el procesamiento de la bebida. La cadena de valor está poco articulada, carece de cohesión interna y prevalece el individualismo. Es necesario innovar las estrategias comerciales y mejorar el desempeño de cada eslabón de la cadena, para fortalecer la presencia del destilado en el mercado del mezcal.

Palabras clave: Raicilla, tradición y cultura, destilado artesanal, mezcales, cadena de valor, mercado.
EVALUASI PROTAP RECALL DI PEDAGANG BESAR FARMASI PT. MILLENNIUM PHARMACON INTERATIONAL TBK CABANG MEDAN
Authors: Surbakti Christica Ilsanna , Waruwu Syukur Berkat , Tampubolon Manuppak Irianto
Published: April 2024

Penarikan kembali suatu produk atau lebih dikenal dengan product recall Hal ini biasa terjadi pada produk cacat yang disebabkan oleh kelalaian perusahaan pada saat produksi. Produsen melakukan tindakan product recall untuk meningkatkan citra produsen dan menjaga kepercayaan konsumen, karena produsen tentunya tidak ingin kehilangan konsumennya. Adapun tujuan recall adalah menjamin proses penarikan obat dari seluruh gudang (pusat/cabang) dan/atau pelanggan dalam batas waktu yang telah ditentukan, dengan prinsip: tepat waktu, dalam jumlah yang tepat, dan dengan proses yang baik dan benar sesuai dengan ketentuan yang berlaku. sesuai petunjuk BPOM/prinsipal agar tidak menimbulkan kerugian bagi masyarakat
POLA PENGGUNAAN OBAT ANALGETIK DAN ANTIPIRETIK DENGAN RESEP DOKTER DI APOTEK UNIVERSITAS SARI MUTIARA INDONESIA MEDAN
Authors: Br Ginting Grace Anastasia , Prayoga Andre , Tampubolon Manuppak Irianto
Published: April 2024

Analgesik atau yang sering disebut dengan obat pereda nyeri merupakan zat yang dapat mengurangi atau memblokir rasa sakit tanpa menghilangkan kesadaran. Pola peresepan obat analgesik dan antipiretik yang tidak tepat juga sering menimbulkan efek samping dan interaksi obat yang menimbulkan reaksi serius dan merugikan obat yang diresepkan dan biasa digunakan untuk mengatasi nyeri, demam, dan proses inflamasi. Tujuan penelitian adalah untuk mendeskripsikan pola penggunaan obat analgesik dan antipiretik yang diresepkan oleh dokter di Apotek Universitas Sari Mutiara Indonesia Medan dan mengetahui pola penggunaan obat analgesik dan antipiretik sesuai dengan pedoman penggunaan. dari analgesik dan antipiretik. Metode dalam penelitian ini adalah penelitian deskriptif dengan menggunakan metode survei retrospektif dan dengan teknik simple random sampling. Jumlah sampel yang digunakan sebanyak 82 resep yang mengandung obat analgetik dan antipiretik. Berdasarkan hasil penelitian, bahwa lembar resep diambil dari 82 lembar resep Analgesik dan Antipiretik di Apotek Universitas Sari Mutiara Indonesia Medan, diperoleh 39 (42%) lembar resep berisi obat analgesik dan antipiretik sebanyak 47 lembar resep. (51%) dan kombinasi analgesik dan antipiretik sebanyak 6 (7%) lembar resep. Penggunaan obat analgesik dan antipiretik terbanyak pada wanita dengan jumlah resep sebanyak 48 resep (59%). Berdasarkan usia, kasus terbanyak terjadi pada usia 20–59 tahun, yaitu sebanyak 52 resep (63%). Dokter yang memberikan resep obat analgesik dan antipiretik terbanyak adalah dokter umum yaitu sebanyak 65 resep (79,28%). Bentuk sediaan yang paling banyak diresepkan adalah bentuk kapsul sebanyak 64 resep (69,56%). Berdasarkan golongan dan nama analgesik yang paling banyak digunakan adalah Golongan Non Opioid yaitu sebanyak 81 resep (98,79%). Berdasarkan golongan dan nama obat antipiretik yang paling banyak digunakan adalah golongan Paraaminofenol yaitu sebanyak 42 resep (79,25%). Berdasarkan jenis obatnya, yang paling banyak digunakan adalah obat analgesik dan antipiretik generik sebanyak 71 resep (87%). Berdasarkan lama penggunaan obat analgesik dan antipiretik yang paling banyak digunakan adalah tiga hari sebanyak 69 (75%) resep, dan kombinasi analgesik dan antipiretik yang digunakan adalah Parasetamol dan Asam Mefenamat sebanyak 4 resep.
SOCIAL IMPACT OF AUTOMATED ACCOUNTING SYSTEMS: A REVIEW: ANALYZING THE SOCIETAL AND EMPLOYMENT IMPLICATIONS OF THE RAPID DIGITIZATION IN THE ACCOUNTING INDUSTRY
Authors: Temitayo Oluwaseun Jejeniwa  , Noluthando Zamanjomane Mhlongo  , Titilola Olaide Jejeniwa
Published: April 2024

This study examines the social impact of automated accounting systems, focusing on the implications for employment, ethical considerations, and broader societal effects. Employing a systematic literature review combined with content analysis, the research draws on recent academic articles, industry reports, and regulatory documents published between 2015 and 2024. The methodology aims to capture a comprehensive view of how automation and artificial intelligence (AI) are reshaping the accounting profession. Key findings reveal that automation acts as a dual-edged sword: it enhances efficiency and accuracy, enabling accountants to focus on higher-value strategic roles, but also raises concerns about job displacement for roles centered on manual tasks. Ethical and privacy considerations emerge as critical issues, necessitating robust frameworks to ensure data protection and maintain trust. The future landscape of accounting is poised to be significantly influenced by ongoing technological advancements, with a transformation in employment patterns and a heightened focus on ethical standards. To navigate this transition, the study recommends strategic initiatives for stakeholders, including updating educational curricula to include relevant digital age skills, developing regulations to address ethical and privacy concerns, and fostering industry collaboration to establish best practices. Lastly, the study underscores the transformative potential of automated accounting systems, highlighting the need for a balanced approach that leverages technological advancements while addressing associated challenges. Future research is encouraged to explore the long-term impacts of automation on the profession, focusing on employment patterns, ethical standards evolution, and societal implications.
Keywords:  Automated Accounting Systems, Employment, Accounting Industry, Digital Transformation.
THE IMPACT OF GENDER MAINSTREAMING ON HUMANITARIAN AID DELIVERY: A POLICY ANALYSIS
Authors: Ayo Amen Ediae  , Chidinma Favour Chikwe  , Kevin Namiiro Kuteesa
Published: April 2024

Gender mainstreaming in humanitarian aid delivery has become increasingly important in recent years as organizations seek to address the differential impact of crises on women, men, girls, and boys. This policy analysis examines the impact of gender mainstreaming on humanitarian aid delivery, focusing on its effectiveness in promoting gender equality and improving the overall outcomes of humanitarian interventions. The analysis explores the evolution of gender mainstreaming in humanitarian aid, highlighting key policy frameworks and guidelines that have shaped its implementation. It also examines the challenges and limitations associated with gender mainstreaming, including issues related to funding, capacity building, and coordination among humanitarian actors. Furthermore, the analysis assesses the impact of gender mainstreaming on the design, implementation, and monitoring of humanitarian programs. It examines how gender considerations have been integrated into needs assessments, program design, and evaluation processes, and how this has influenced the quality and effectiveness of humanitarian aid delivery. The analysis also considers the broader implications of gender mainstreaming on humanitarian action, including its potential to transform power dynamics, challenge gender stereotypes, and promote women's leadership in humanitarian decision-making processes. It highlights the importance of adopting a gender-sensitive approach that recognizes and addresses the specific needs and vulnerabilities of women, men, girls, and boys in humanitarian settings. Overall, this policy analysis underscores the critical importance of gender mainstreaming in humanitarian aid delivery and calls for greater commitment and investment in gender-responsive programming. It concludes with recommendations for strengthening gender mainstreaming efforts, including enhancing coordination among humanitarian actors, increasing funding for gender-sensitive programming, and promoting gender equality within humanitarian organizations.
Keywords: Impact: Gender Mainstreaming, Humanitarian, Aid Delivery, Policy Analysis.
A REVIEW OF ADVANCED EDUCATIONAL METHODS AND THEIR IMPACT ON U.S. COMPETITIVENESS IN THE GLOBAL MARKET
Authors: Olateju Temitope Akintayo  , Chima Abimbola Eden  , Oyebola Olusola Ayeni  , Nneamaka Chisom Onyebuchi
Published: April 2024

This research explores the integration of advanced educational methods in the United States and its implications for national competitiveness. The literature review underscores the critical link between education and economic competitiveness by examining the historical evolution of the U.S. education system. U.S. education's current state reveals strengths and weaknesses, necessitating innovative solutions. The potential impact of advanced methods on student outcomes, the reduction of educational disparities, and alignment with workforce needs are analyzed. Challenges such as resistance to change, equity concerns, and ethical considerations are addressed. Policy implications emphasize the need for flexible, equitable, and data-driven strategies to maximize the transformative potential of advanced educational methods for a more inclusive and globally competitive future.
Keywords: Advanced Educational Methods, U.S. Education System, Global Competitiveness, Student Outcomes, Educational Disparities, Policy Implications.
CONCEPTUALIZING E-GOVERNMENT INITIATIVES: LESSONS LEARNED FROM AFRICA-US COLLABORATIONS IN DIGITAL GOVERNANCE
Authors: Temitayo Oluwaseun Jejeniwa  , Noluthando Zamanjomane Mhlongo  , Titilola Olaide Jejeniwa
Published: April 2024

This review paper explores the dynamics, challenges, and successes of Africa-US collaborations in e-Government, highlighting the significant impact of digital governance initiatives on improving public service delivery and governance. Through an examination of theoretical frameworks, key concepts, and contextual differences, the paper synthesizes lessons learned and best practices from these international collaborations. It identifies critical success factors, including leadership, stakeholder engagement, and capacity building, while also addressing common challenges such as the digital divide and technological infrastructure. Emerging trends such as artificial intelligence, blockchain, and digital identity systems offer new avenues for future collaborations. The paper concludes with recommendations for strengthening these partnerships, emphasizing the importance of technology transfer, policy harmonization, and sustainable development goals alignment.
Keywords: E-Government, Digital Governance, Africa-Us Collaborations, Technology Transfer, Digital Divide, Emerging Technologies.
THE STRATEGIC VALUE OF BUSINESS ANALYSTS IN ENHANCING ORGANIZATIONAL EFFICIENCY AND OPERATIONS
Authors: Oladapo Adeboye Popoola  , Henry Ejiga Adama  , Chukwuekem David Okeke  , Abiodun Emmanuel Akinoso
Published: April 2024

Business analysts play a crucial role in enhancing organizational efficiency and operations by bridging the gap between business needs and technological solutions. This review explores the strategic value of business analysts in driving organizational success through effective analysis, communication, and stakeholder engagement. Business analysts act as key facilitators in organizations, translating business objectives into actionable requirements for technology solutions. By conducting thorough analysis of business processes, systems, and data, business analysts identify opportunities for improvement and recommend strategic solutions to enhance operational efficiency. Their role extends beyond mere problem-solving; they also play a pivotal role in aligning business goals with technology initiatives, ensuring that projects deliver tangible value to the organization. Furthermore, business analysts excel in communication and stakeholder engagement, acting as liaisons between business units, IT teams, and external vendors. Their ability to translate complex technical concepts into clear, understandable language enables them to facilitate collaboration and consensus among diverse stakeholders. This skill is particularly valuable in Agile environments, where collaboration and communication are key principles. Moreover, business analysts are instrumental in driving organizational change and transformation. By conducting impact assessments, developing change management strategies, and providing training and support, business analysts ensure that technology implementations are successful and sustainable. Their holistic approach to problem-solving and their focus on delivering value make them invaluable assets to organizations seeking to improve efficiency and operations. In conclusion, the strategic value of business analysts in enhancing organizational efficiency and operations cannot be overstated. Their unique blend of analytical skills, communication prowess, and stakeholder engagement abilities make them indispensable in driving organizational success. By leveraging the expertise of business analysts, organizations can streamline processes, improve decision-making, and achieve their strategic objectives with greater efficiency and effectiveness.
Keywords:  Strategic Value, Business Analysts, Enhancing, Organizational Efficiency, Operations.
Le temps psychologique et l’engagement dans l’évaluation des commotions cérébrales
Authors: Cantin Maya , Gingras Marie-Laurence , Roussel Noémie , Patry Mireille , Chamberland Cindy , Tremblay Sébastien
Published: April 2024

Plusieurs chercheurs et professionnels de la santé soulignent l’importance d’améliorer la validité écologique des outils de détection des commotions cérébrales (CC), notamment en pratique sportive afin de susciter davantage l’engagement des athlètes envers le processus d’évaluation. Le développement d’une nouvelle approche de détection de CC a permis d’identifier la perception de la durée de l’évaluation comme un facteur potentiellement déterminant de l’engagement. La présente étude vise à déterminer s’il existe une relation entre l’engagement de l’individu et la durée perçue d’une tâche en fonction de sa structure segmentée ou non segmentée. Pour ce faire, le visionnement de séquences de jeu de soccer via l’application de Simulation ENgageante Immersive et Cognitive (SENIC) est effectué par deux échantillons de 22 étudiants-athlètes du Rouge et Or de l’Université Laval. À la lumière des résultats, il ne semble pas avoir d’influence significative de la segmentation de la tâche  sur l’engagement auto-rapporté des participants ni sur l’expérience temporelle subjective. De plus, ces deux dernières variables ne présentent pas de corrélation significative. Les résultats de cette étude contribueront à rendre les outils de détection des CC plus engageants, rendant la performance des athlètes plus représentative de leur pratique sportive. C’est en comprenant le lien entre la performance et la réaction des athlètes au test SENIC qu’il serait possible d’améliorer le suivi des CC dans le domaine du sport.
Effet de la stimulation visuelle rythmique sur la perception de la douleur
Authors: Deslauriers Coralie , Côté-Cazes Thaliane , Etcheverry Audrey , Coll Michel-Pierre
Published: April 2024

La douleur chronique affecte plusieurs milliers d'individus et réduit leur qualité de vie. Des traitements efficaces comportant peu d'inconvénients sont donc nécessaires. Une technique potentielle pour diminuer la douleur est la stimulation visuelle rythmique à l’aide de fréquences alpha (8-12 Hertz). Toutefois, peu d’études démontrent son efficacité. Ainsi, cette étude vise à déterminer si l’effet de la stimulation visuelle rythmique à une fréquence alpha de 10 Hertz diminue la perception de la douleur induite par un laser comparativement aux conditions Base et 1 Hertz. Vingt participant.es en santé âgé.es entre 19 et 37 ans ont été recruté.es. Les participant.es étaient exposé.es à chaque condition de stimulation visuelle rythmique (1 Hertz et 10 Hertz) pendant dix minutes. Après chaque condition, la douleur était évaluée sur une échelle visuelle analogue. Les résultats indiquent que la stimulation visuelle rythmique a un effet non spécifique aux fréquences de 10 Hertz et de 1 Hertz sur la perception de la douleur. Il est proposé que l’habituation, des mécanismes différents et des petites tailles d’effet ont pu influencer les résultats. Cette étude a permis d’évaluer que la stimulation visuelle rythmique a un effet modeste sur la douleur aiguë expérimentale.
Sacituzumab Govitecan (Trodelvy)
Authors: CADTH
Published: April 2024

CADTH reimbursement reviews are comprehensive assessments of the clinical effectiveness and cost-effectiveness, as well as patient and clinician perspectives, of a drug or drug class.
The assessments inform non-binding recommendations that help guide the reimbursement decisions of Canada’s federal, provincial, and territorial governments, with the exception of Quebec.
This review assesses sacituzumab govitecan (Trodelvy), 180 mg lyophilized powder for solution for injection, for IV use.
Indication: For the treatment of adult patients with unresectable, locally advanced or metastatic, HR-positive, human epidermal growth factor receptor 2-negative (immunohistochemistry [IHC] 0, IHC 1+ or IHC 2+/in situ hybridization-negative) breast cancer who have received endocrine-based therapy and at least 2 additional systemic therapies in the metastatic setting.
SISTEM INFORMASI PENERIMAAN SISWA BARU SMA KRISTEN WAMENA BERBASIS WEB
Authors: HELUKA YESKIEL
Published: April 2024

Research on the new student registration information system at Wamena Christian High School was carried out using a Waterfall system design, namely a linear system design method consisting of each stage that must be passed (completed first) and then proceed to the next stage. System architecture modeling uses a structured method, namely by describing system users with a picture of data flow and the interaction of the information system with data bases as data storage media. The use of the new student registration information system at Wamena Christian High School can help the process of accepting new students and make reporting easier.
ABSTRAKPenelitian sistem informasi pendaftaran Siswa Baru di SMA Kristen Wamena dilakukan dengan menggunakan perancangan sistem Waterfall yaitu sebuah metode perancangan sistem linear yang terdiri dari tiap tahapan harus dilalui (diselesaikan terlebih dahulu) bisa lanjut ketahap berikutnya. Pemodelan Arsitektur sistem menggunakan metode terstruktur yaitu dengan menggambarkan Pengguna sistem dengan gambaran alir data serta interaksi sistem informasi dengan data bases sebagai media penyimpanan data. Penggunaan sistem informasi pendaftaran siswa baru di SMA Kristen Wamena bisa membantu proses penerimaan siswa baru dan mempermudah pelaporannya.
ANALISIS MANAJEMEN SAMPAH RUMAH TANGGA DI INDONESIA: LITERATUR REVIEW
Authors: SUTALHIS M. , NOVARIA EVA
Published: April 2024

Household waste management is an important issue faced by multiple parties, from government, society, business, tourism and academics. The problems in this Literature Review include who are the main stakeholders involved in household waste management, what is the government's contribution to waste management efforts, especially household waste?, and what are the factors that influence the level of community participation in household waste management and management strategies? effective and sustainable household waste. . This research uses a qualitative approach (library research method). This study uses document analysis as a data collection approach, collecting information from journal articles, conferences, research papers, and internet media. The results of the analysis are that effective and sustainable household waste management requires a combination of various methods and strategies. The application of 3R and the Circular Economy concept can be a solution to minimize waste and create a sustainable waste management system. Most of what is used is plastic waste that can be recycled.
ABSTRAKManajemen sampah rumah tangga merupakan isu penting yang dihadapi oleh multi pihak, dari pemerintah, masyarakat, dunia usaha, pariwisata, dan pihak akademik. Permasalahan dalam Reviu Literatur ini adalah lain siapa saja pemangku kepentingan utama yang terlibat dalam manajemen sampah rumah tangga, bagaimana kontribusi pemerintah terhadap upaya manajemen sampah khususnya sampah rumah tangga?, dan apa saja faktor yang mempengaruhi tingkat partisipasi masyarakat dalam manajemen sampah rumah tangga serta strategi pengelolaan sampah rumah tangga yang efektif dan berkelanjutan. . Penelitian ini menggunakan pendekatan kualitatif (metode penelitian perpustakaan). Studi ini menggunakan analisis dokumen sebagai pendekatan pengumpulan data, mengumpulkan informasi dari artikel jurnal, konferensi, makalah penelitian, dan media internet. Hasil Analisis adalah manajemen sampah rumah tangga yang efektif dan berkelanjutan membutuhkan kombinasi berbagai metode dan strategi. Penerapan 3R dan konsep Circular Economy dapat menjadi solusi untuk meminimalkan limbah dan menciptakan sistem pengelolaan sampah yang berkelanjutan. Sebagian besar yang dimanfaatkan adalah sampah plastik yang dapat di daur ulang.
ALERGIA À PROTEÍNA DO LEITE DE VACA: UMA REVISÃO DE LITERATURA
Authors: Fiquene Letícia Paiva , Silva Helen Martins , Petitinga Kellym Monise Espindola dos Santos , Tanuri Eduardo Bezerra , Vieira Cláudia Caroline Lima dos Reis
Published: April 2024

A alergia à proteína do leite de vaca (APLV) é definida como uma reação adversa mediada pelo sistema imunológico às proteínas presentes no leite de vaca. Existem dois tipos principais de APLV: a mediada por IgE e a não mediada por IgE. A forma mediada por IgE é geralmente mais rápida em sua manifestação, com sintomas que aparecem de minutos a algumas horas após o consumo do leite. Já a forma não mediada por IgE tem uma apresentação mais tardia, com sintomas que podem levar horas ou dias para se desenvolver. Esta revisão narrativa de literatura reuniu artigos publicados nos últimos cinco anos nas bases de dados PUBMED e SciELO, objetivando indicar os principais fatores de risco para o desenvolvimento de APLV. Concluiu-se que os principais fatores de risco para o desenvolvimento da APLV estão relacionados com: fatores genéticos, exposição ambiental, fatores dietéticos e via de parto devido à microbiota.
A robust numerical method for the generation and simulation of periodic finite-amplitude internal waves in natural waters
Authors: Lloret Pierre , Diamessis Peter J. , Stastna Marek , Thomsen Greg N.
Published: April 2024

Abstract. The design and implementation of boundary conditions for the robust generation and simulation of periodic finite-amplitude internal waves is examined in a quasi two-layer continuous stratification using a spectral-element-method-based incompressible flow solver. The commonly-used Eulerian approach develops spurious, and potentially catastrophic, small-scale numerical features near the wave-generating boundary in a nonlinear stratification when the parameter A / (δ c) is sufficiently larger than unity ; A, δ are measures of the maximum wave-induced vertical velocity and pycnocline thickness, respectively, and c is the linear wave propagation speed. To this end, an Euler-Lagrange approach is developed and implemented to generate robust high-amplitude periodic deep-water internal waves. Central to this approach is to take into account the wave-induced (isopycnal) displacement of the pycnocline in both the vertical and (effectively) upstream directions. With amplitudes not restricted by the limits of linear theory, the Euler-Lagrange-generated waves maintain their structural integrity as they propagate away from the source. The advantages of the high-accuracy numerical method, whose minimal numerical dissipation cannot damp the above near-source spurious numerical features of the purely Eulerian case, can still be preserved and leveraged further along the wave propagation path through the robust reproduction of the nonlinear adjustments of the waveform. The near-and-far-source robustness of the optimized Euler-Lagrange approach is demonstrated for finite-amplitude waves in a sharp quasi two-layer continuous stratification representative of seasonally stratified lakes. The findings of this study provide an enabling framework for two-dimensional simulations of internal swash zones driven by well-developed nonlinear internal waves and, ultimately, the accompanying turbulence-resolving three-dimensional simulations.
Oribasius’ Collectiones medicae (books I to IV): language and style, sources, contents
Authors: Manco Caterina
Published: April 2024

By relying on books I-IV of Oribasius’ Collectiones medicae, which deal with the powers of foods and their methods of cooking, in the first section of this contribution, we will present the authors mentioned by Oribasius and in what way the physician of the emperor Julian the Apostate arranges the material excerpted from them. In the second part, through a comparison of Oribasius’ book IV, 1 (taken as a sample passage) and Galen’s originals, we will try to point out the stylistic characteristics of Oribasius’ prose.
Resumen. Apoyándonos en los libros I-IV de las Collectiones medicae de Oribasio, que tratan de las propriedades de los alimentos y de sus métodos de cocción, en la primera sección de esta contribución presentaremos los autores mencionados por Oribasio y de qué manera el médico del emperador Juliano el Apóstata organiza el material extraído de ellos. En la segunda parte, a través de una comparación del libro IV, 1 de Oribasio (tomado como pasaje de muestra) y los originales de Galeno, intentaremos señalar las características estilísticas de la prosa de Oribasio.
Metáforas espinosas. Sobre los términos anatómicos ῥάχις, ἀνθερεών y γλῶττα
Authors: Andrés-Alba Iván
Published: April 2024

Este estudio, inserto en el marco de la Lingüística Cognitiva, explora los términos anatómicos ῥάχις ‘espinazo’, ἀνθερεών ‘mentón’ y γλῶττα ‘lengua’ con el objetivo de identificar las metáforas conceptuales subyacentes. Para ello, tras precisar el referente anatómico al que aludía en griego antiguo cada uno de estos términos, se analizará su desarrollo metafórico a partir de la noción de «puntiagudo» presente en elementos como espinos o espigas, evidenciando así el papel de la metáfora de imagen en la creación del léxico anatómico en la lengua griega.
Resilience and Psychological Distress in Genetic Testing for Alzheimer's Disease
Authors: Burgei Alicia
Published: April 2024

The relationship between resilience and psychological distress resulting from genetic testing for Alzheimer’s disease among non-cognitively impaired individuals is examined in this study. Preventative genetic testing determines the likelihood of developing or passing on genetic disorders. However, receiving genetic information, especially regarding incurable diseases like Alzheimer’s disease, can lead to significant psychological distress. Resilience, the ability to cope with adversity and recover quickly, is considered a protective factor against psychological distress. The purpose of this study is to investigate whether higher levels of resilience are associated with lower psychological distress from genetic testing for Alzheimer’s disease and to determine if having a familial history of Alzheimer’s disease influences this relationship. An online cross-sectional survey was conducted among 181 non-cognitively impaired participants (43.6% Male; 54.1% Female; Mage=38.1 [13.9]) using the Impact of Genetic Testing for Alzheimer’s Disease (IGT-AD) scale and the Brief Resilience Scale (BRS), along with a question about family history of Alzheimer’s disease. The results indicated a significant negative correlation between resilience and psychological distress, suggesting that individuals with higher resilience experienced lower distress related to genetic testing. However, family history did not mediate the relationship, meaning the protective effect of resilience was consistent regardless of familial risk. These findings have implications for developing targeted support services and resilience-based interventions to help individuals cope with the emotional impact of genetic testing for Alzheimer’s disease. Further research could explore other potential protective factors and examine the long-term impact of genetic testing results on psychological well-being and behavior.
The Effects of Psychosocial and Traumatic Stressors on MCI Diagnosis
Authors: Goulden Katherine
Published: April 2024

Background and Objective: Toxic stress exposure can have effects across the lifespan. Studies of civilians and veterans suggest a connection between psychosocial and traumatic stressor exposure in adulthood and a diagnosis of dementia later in life. The objective of this study was to investigate the impact of psychosocial and traumatic stressors on rates of MCI (Mild Cognitive Impairment) diagnosis in Vietnam Era Twin Study of Aging participants. Methods: 1,237 twin participants from the VETSA study were aged 61.72 ± 2.44 years at the time of data collection. Traumatic stress was measured by clinical interviewing, with psychosocial stressors quantified by self-report measures. Neuropsychological assessment determined MCI diagnosis. Previously conducted genotyping determined ApoE genotype. Mixed model analysis was used to determine effects on MCI diagnosis. Results: Our results from the mixed model analysis did not find a significant relationship between psychosocial and traumatic stress exposure and MCI diagnosis. PTSD diagnosis, measured by the DIS-III-R, collected for the Harvard Drug Study in 1996 (F = 0.249, p = 0.618) does not have a significant effect on MCI diagnosis. Life stress exposure, measured by the Holmes and Rahe (1967), (F = 0.249, p = 0.618) does not have a significant effect on MCI diagnosis. Significant associations were determined using the Type III fixed effects. Associations were considered statistically significant at p < 0.05, two-tailed. Implications: Few subjects in Wave 2 of VETSA had MCI (n = 147), due in part to the age of the participants at the time (Mean 61.72 ± (2.44 years)). This led to a lack of power in our analysis. Future studies should examine all available VETSA data.
Can Induced Awe Reduce Anti-Gay Prejudice in Heterosexual Adults and Does the Need for Closure Moderate this Effect?
Authors: Gupta Pankaj , Hamlin Iain
Published: April 2024

With sexual prejudice continuing to be widely prevalent and seriously harmful, there is a need to find ways to reduce anti-gay prejudice (AGP). This online experimental study examined if a novel intervention, induced awe, can reduce AGP; if those high in need for closure (NFC) show higher AGP; and if NFC moderates the effect of awe on AGP. In total, 154 heterosexual adults completed the Need for Closure Scale (Roets & Van Hiel, 2011) before being randomly assigned to one of three emotion inducement interventions – 1) watching a 4.43 min long video of the target emotion, awe, 2) watching the comparison emotion, amusement, or 3) watching a neutral emotion as a control. Post intervention, the participants completed the explicit measures Homosexuality Attitudes Scale (HAS; Kite & Deaux, 1986). Data were analysed using a 2 (NFC) x 3 (emotion type) independent factorial ANOVA. None of the three hypotheses were supported since there were no main effects of awe or NFC on AGP, and no interaction effect of awe and NFC on AGP. Key implications of these results were 1) awe inducement does not change prejudicial attitudes at an explicit level (Dale et al., 2020), 2) factors beyond NFC, like Right Wing Authoritarianism (RWA) and Social Dominance Orientation (SDO), may influence the effectiveness of awe in reducing prejudice, and 3) questions were raised about certain boundaries for awe’s effectiveness. Methodological modifications suggested for future research include using implicit measures or veiled elicitation methods for authentic measurement of AGP, employing more potent awe elicitors, and assessing the mediating role of RWA and SDO on the effect of NFC on AGP.
Loneliness During the COVID-19 Pandemic: Implications for Mental Health and Substance Use
Authors: Cordaro Millie , Johnson Emma , Kinstley Chris , Haskard-Zolnierek Kelly , Medina Rachel , Perrotte Jessica , Howard Jeffrey , Howard Krista
Published: April 2024

Aim: Traumatic stressor events disrupt the normal daily functioning of individuals and groups, and the consequences of collective trauma magnify psychopathology and mental health issues. One overlooked mental health implication of traumatic stress is loneliness. The current study examines loneliness as a result of traumatic stress and its psycho-social correlates, including substance abuse and changes in daily health behaviors. Design: Cross-sectional, nationwide, online survey. Methods: This study was a cross-sectional, nationwide online survey that included 2,530 adults in the United States, 18-83 years old, and examined the associations between loneliness and psychosocial factors and substance use during the initial part of the COVID-19 pandemic. Results: Increased loneliness was associated with younger age, single marital status, and lower levels of education. Mental health disorders, including major depression, generalized anxiety, and somatization, were also associated with high levels of loneliness. Further, individuals with high levels of loneliness were more likely to report increased substance use, including alcohol and illicit drugs. Discussion: The findings of this study indicate that during times of collective traumatic events, high levels of loneliness are a risk factor for mental health and substance use. Further initiatives are warranted to create awareness and institute routine screenings for symptoms of loneliness to mitigate mental health distress and increases in substance abuse.
Knowledge Management in Parliament. A quantitative overview for Europe
Authors: Mittelstädt René
Published: April 2024

Despite being the fundamental pillar of our democratic systems, there has been a notable scarcity of research on knowledge management within parliamentary settings. The few existing approaches fail to consider the unique structure of parliaments and the challenges newly elected members face. Previous research concluded that knowledge in parliaments still tends to be tacit, informal, and not recorded. In view of the multitude of highly knowledge-intensive crises in the last decade, the need for political knowledge management becomes apparent. This paper investigates how members of the national parliaments in Europe manage their knowledge relevant for policy-making, using original data collected in a quantitative online-survey in mid-2023. I was able to show that both organizational and cultural barriers hinder good knowledge work and that a systematic approach is still not being pursued. I come to the conclusion that modern politics lacks sufficient resources and know-how to adequately evaluate and apply the flood of information in everyday business. This deficiency is especially detrimental to inexperienced MPs and members of the opposition. Building on these findings, a proposed model for political knowledge management is presented. The central pillars are, on the one hand, the creation of awareness, the formulation of a knowledge strategy, the more intensive integration of external expertise and the establishment of IT support.
Performance Characteristics of a Newly Developed Asymmetric Seven-Level Inverter Utilizing Various Hybrid Pulse Width Modulation Strategies
Authors: S. Farook
Published: April 2024

This study unveils a notable breakthrough in inverter technology, holding promise for substantial improvements in voltage quality and the attenuation of harmonic distortions within power systems. This study concentrates on the design and implementation of a novel Seven-Level Asymmetric Inverter (NSLAI) by incorporating various hybrid Pulse Width Modulation (PWM) techniques. The primary goal is to improve the output voltage magnitude while decreasing the Total harmonics compared to conventional PWM methods.
The investigation introduces a novel Seven-Level Asymmetric Inverter (NSLAI) with innovative Hybrid Pulse Width Modulation (PWM) strategy. The purpose of this study is to investigate the distinct features of a recently developed asymmetric seven-level inverter, with a focus on exploring its characteristics through the implementation of diverse hybrid pulse width modulation strategies. Hybrid PWM methodology intricately centers on enhancing voltage quality and achieving better harmonious spectral characteristics. The gate signal producing approach for this suggested PWM technology incorporates a hybrid PWM methodology that combines trapezoidal and sinusoidal waveforms, as well as a standard triangular carrier signal enabling NSLAI.  The hybrid version of PWM practices is deliberately used to generate switching signals for the NSLAI. An intensive evaluation of numerous indicators of effectiveness across multiple modulation indexes leads in the demonstrating of quantitative findings that compare the unique Hybrid PWM practice with established PWM tactics. Notably, the hybrid reference Carrier Overlapping strategy has emerged as a leading approach surpassing conventional pulse width modulation techniques. It achieves a significantly higher fundamental Root Mean Square voltage output and remarkably lower percentage of Total Harmonic Distortion values compared to all within the hybrid reference Variable Frequency strategy. The principal analytical tool used in the modeling investigation is MATLAB-SIMULINK. This study marks a watershed moment in the development of inverters, claiming significant improvements in battery power quality and distortion caused by harmonics avoidance across power systems, as evidenced by extensive simulation and prototype-based discoveries.
Real-Time Telerobotic Manipulator Control Using Hand Gestures
Authors: Krithika Vaidyanathan
Published: April 2024

Control of Objects from a remote distance became an important factor for mankind about decades ago. Since then there has been a tremendous amount of improvements in the field of remote control. Once the “Internet of Things(IoT)” had been introduced, remote control technology across various applications has also opted for this method of data transmission from device to device over the internet. Through this work, a new way of controlling a robotic arm that can mimic/repeat human hand gestures and operate in a remote location through the use of IoT technology is proposed. The robotic arm design involves generative designing for weight reduction over a five end-effector model for cost and weight reduction purposes, also for the cause of hand gesture recognition a Neural Network has been trained and implemented behind an application that has been completely programmed in python. As compared to traditional methods of controlling a robotic arm the proposed method provides better cost efficiency, data transmission, data collection, and accessibility due to the abundant availability of computers, and adaptability towards the growing technology.
Ultra-Low Power 9T FinFET Based SRAM Cell for IoT Applications
Authors: Prashant U. Jain
Published: April 2024

The rapid proliferation of Internet of Things (IoT) devices has escalated the demand for energy-efficient memory solutions. The development of SRAM (Static Random-Access Memory) has gathered significant attention, particularly for low-power applications and portable devices. This research introduces a novel approach to ensure robust performance and operational integrity, all while adhering to stringent power constraints amidst process and temperature fluctuations. This quest for alternative nano-devices has been ignited by the scaling and channel control challenges intrinsic to CMOS technology. Among the array of alternatives, including FinFETs, TFETs, and CNTFETs, FinFETs have emerged as strong contenders. FinFET SRAMs contribute to the ongoing drive for electronic devices to become more compact and energy-efficient. They offer a distinct advantage as a promising CMOS substitute, attributed to their high performance, stability, with low power consumption characteristics at the nanoscale. The study proposes an ultra-low power 9T FinFET based SRAM cell meticulously designed for IoT applications. Leveraging the unique attributes of FinFET based 9T cell, the proposed SRAM cell is tailored to achieving minimal power consumption while maintaining inherent stability. The study assesses the performance of the proposed SRAM cells for power dissipation, stability, speed, and energy efficiency, and compares them with existing SRAM structures. The results are obtained through the Monte Carlo simulation technique, which evaluates circuit performance under specified conditions. The study achieves remarkable efficiency gains with 9T SRAM cells compared to other configurations. Additionally, the reduced read and write access times facilitate expedited data retrieval and storage operations.
DAMPAK POLA ASUH ORANG TUA TERHADAP PERRKEMBANGAN KARAKTER DISIPLIN ANAK DI TK RA DIPONEGORO 143 KALITAPEN
Authors: Musrifah Siti
Published: April 2024

Pola asuh orang tua yang beragam akan memberikan dampak kepada perkembangan karakter anak usia dini. Penelitian ini memiliki tujuan untuk mengetahui tentang dampak pola asuh otoriter, permisif, dan demokratis orang tua dalam perkembangan karakter disiplin anak di TK RA Diponegoro 143 Kalitapen. Metode penelitian yang digunakan yaitu naratif dengan pendekatan kualitatif. Populasi penelitian ini adalah orang tua murid TK RA Diponegoro 143 Kalitapen dengan jumlah 35 responden. Sampel yang digunakan yaitu 35 responden yang dipilih dengan teknik total sampling atau sampel jenuh. Teknik yang digunakan untuk memperoleh data menggunakan kuisioner.  Analisis data yang dipilih yaitu analisis naratif berdasarkan hasil kuisioner. Hasil penelitian menunjukkan (1) pola asuh otoriter memiliki pengaruh terhadap karakter disiplin anak sebesar 46%, (2) pola asuh permisif memiliki pengaruh terhadap karakter disiplin anak sebesar 17%, dan (3) pola asuh demokratis memiliki pengaruh terhadap karakter disiplin anak sebesar 37%.
PENERAPAN METODE SOSIODRAMA PADA SENTRA BERMAIN PERAN
Authors: Hasanah Uswatun
Published: April 2024

The real world of the child is the world of play, play has very important benefits for the growth and development of the child, both psychic and physical child, through play children test their guesses about how the world functions, the child can explore and experiment with various things around him. Role-playing is not an easy activity, children who often practice with drama games are often those who succeed in life as adults. Sociodrama activities at the role-playing center at Yabakii Kesugihan Kindergarten are held from 07.30 to 10.00, in class B3 the role center learning is carried out one month twice face-to-face, namely every month of the first week and the third week with a total of 17 students. Sociodrama Activities in Role-Playing Center Learning Develop abstract, language, Social Emotional thinking skills, connect the knowledge that children already have with new knowledge, using role-playing tools that are small in size or according to the actual size.