bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling of the Hemodynamics of Vascular Prostheses "Kemangiprotez" in Silico
Authors: Клышников К.Ю. , Klyshnikov K.U.
Published: December 2017

The paper describes aspects of the application of numerical simulation of fluid flows in clinical medicine with interventions on the human
vascular system. The modeling method used in the study is verified using the data of the doppler sonography of the patient underwent vascular
replacement. It was shown that the deviation between the numerical experiment and the clinical data - pressure curves at the inlet and
outlet of the studied vessel, is 20%. The obtained quantitative characteristics of the flow: peak systolic velocity, final diastolic velocity,
minimum diastolic velocity, resistivity index, pulsatility index, systole/diastole index are comparable between verification and experimental data.
Thus, for the proximal site of the clinical vessel the corresponding indices were 96.5 cm/s; 4.5 cm/s; 36.2 cm/s; 1.05; 11.5; 21.3. For simulation,
107.9 cm/s; 4.44 cm/s; 43.9 cm/s; 1.05; 12.0; 24.3. In addition, the work describes the application of tested method in two clinical vascular
prostheses "KemAngioprotez" for the assessment of zones of increased shear stress and, thus, the risk of thrombus formation. It is shown that
the distribution of critical zones corresponds to zones of anastomosis between prosthesis segments, which may be a potential location for optimization
of the device.
Resenha de Argumentação em contexto escolar: relatos de pesquisa, de Liberali, Damianovic, Ninin, Mateus & Guerra
Authors: Larré Julia Maria Raposo Gonçalves de Melo , Richter Carla Lima
Published: December 2017

Os estudos relacionados à argumentação colaborativa em situação escolar vêm atualmente sendo realizados em diversos grupos de pesquisa de variados contextos acadêmicos no Brasil. Esta resenha apresenta a obra Argumentação em contexto escolar: relatos de pesquisa, organizada Liberali, Damianovic, Ninin, Mateus & Guerra, que propõe contribuir com a temática supracitada, trazendo um conjunto de pesquisas que possuem como objetivo principal proporcionar discussões e trazer aporte teórico para a compreensão dos processos argumentativos na esfera educacional.
A construção da argumentação no resumo acadêmico a partir da utilização dos operadores de contraposição
Authors: Da Silva Marcos Antônio , Andrade Luiz Henrique Santos de
Published: December 2017

Este estudo analisa a polifonia de enunciadores, bem como os operadores argumentativos de contraposição, em resumos acadêmicos que fazem parte de um projeto “guarda-chuva” maior. Para tal empreendimento, lançamos mão da Teoria da Argumentação na Língua proposta por Oswald Ducrot (1987, 1988) e Anscombre e Ducrot (1983, 1994). A metodologia empregada é de natureza descritiva e qualitativa, tendo em vista que estamos atentos ao funcionamento desses operadores tanto como elementos coesivos quanto pelo fato de serem utilizados como uma estratégia argumentativa, orientando os enunciados para determinadas conclusões. A análise realizada no corpus, constituído de cinco resumos acadêmicos, constatou que se trata de um gênero discursivo que apresenta como principal estratégia argumentativa a polifonia de enunciadores, em que os operadores de contraposição analisados não funcionam apenas como elementos de ligação de palavras e orações, mas também ativam pontos de vista diferentes, corroborando para o leitor perceber o posicionamento do locutor responsável pelo texto.
A constituição do ethos em perguntas e respostas: o caso da entrevista
Authors: Radi Alan Ribeiro , Figueiredo Maria Flávia
Published: December 2017

Com base no conceito retórico de ethos, buscamos, nesta pesquisa, averiguar como dois oradores de caracteres distintos engendram discursivamente uma imagem positiva de si no objetivo de corresponder às expectativas de seus respectivos auditórios. Esperamos, dessa maneira, alcançar um objetivo maior que é entender de que forma os gêneros discursivos, os propósitos comunicativos e o ethos se interrelacionam. Para isso, contamos com a teoria retórica com fundamento em Aristóteles, Eggs, Meyer e Fiorin. No que concerne ao estudo dos gêneros, auxiliam-nos Cavalcante e Marcuschi. Ademais, valemo-nos das contribuições de Figueiredo no tocante à prosódia. Como corpus, selecionamos uma entrevista concedida por Padre Fábio de Melo a Danilo Gentili, que foi analisada de forma qualitativa. Os resultados demonstram que, na interrelação entre gênero discursivo, propósito comunicativo e ethos, o propósito comunicativo atua como protagonista, exercendo papel coercitivo sobre os gêneros nos quais o ethos se manifesta.
الجملة في اللغة العربية (دراسة تقابلية بين مدرسة النحو التقليدية والحديثة)
Authors: Roviin Roviin
Published: December 2017

This article discusses about the difference between traditional and modern nahwu schools in studying of the Jumla (sentence). Jumla is a compound words because it is a combination of two or more words. Traditional nahwu schools agree that the jumla is any structure that fully benefits. The modern nahwu schools hold that the jumla  is all statements consisting of two principal things, the first is the earlier one and the second is the last part which has the function of statement or question and the other. The traditional nahwu schools divide the jumla  into two parts, the first is the ismiya and the second is fi'liya. The jumla ismiya consists of mubtada and khobar while the jumla fi'liya is composed of fi'il and fa'il. The division of jumla according to modern nahwu schools is the jumla basitho and the jumla murokkaba. The  jumla basitho consists of one composition only, while the jumla murokkaba consists of musnad and musnad ilaih. The  jumla ismiya can be defined as a musnad in which the form of words, phrases or compositions. Whereas if the musnad is a fi'il structure then it is called the composition of fi'liyah, either consisting of words, phrases or compositions.
The effectiveness and safety of mht depending on the type, route of administration of estrogens, and the type of progestogen. Analysis of data from clinical trials and international recommendations
Authors: С. О. Шурпяк
Published: December 2017

The hormone therapy remains the most effective method for treating of the vasomotor symptoms and genitourinary syndrome in menopause. The evidence available to date suggests that for women younger than 60 and with a postmenopause no more than 10 years without contraindications, the benefits of administering systemic hormone therapy for the treatment of vasomotor symptoms, sleep disorders and prevention of bone loss exceed possible risks. In addition, the data about statistically significant reduction in all-cause mortality in women who initiate hormone therapy before the age of 60 and/or 10 years after the onset of menopause have been obtained.Menopausal hormone therapy (MHT) includes a wide range of hormonal drugs and administration routes that potentially have different risks and benefits, and therefore the term “class effect” is misleading and inappropriate. The risks of menopausal hormone therapy vary depending on the composition, dose and route of administration of hormones, as well as the timing of the onset and duration of use of both estrogens and progesterone. The use of transdermal estrogens in combination with progesterone seems safer for venous thromboembolism, especially in high-risk women. The use of transdermal estrogen drugs in comparison with oral estrogens is associated with a lesser likelihood of developing thrombotic risk, and possibly the risk of developing stroke and coronary heart disease. If progesterone is needed, micronized progesterone is a safer alternative.MHT requires a periodic reassessment of the benefits and risks for deciding whether to continue or stop using it. The use of postmenopausal hormone therapy in women with menopausal disorders should be based on an assessment of all risk factors for cardiovascular disease, age and time from the onset of menopause. The duration of therapy should be motivated by the indications, and the decision should be taken in conjunction with the doctor.
THE RELATIONSHIP BETWEEN DA’WAH AND ENTREPRENEURSHIP: A CASE STUDY ON INTEAM GROUP IN ENTERTAINMENT INDUSTRY IN MALAYSIA
Authors: Syarmimi J. Nur Aimie , Ahsan Ambo , , Z. E. R., Fathiah , M.N. Rafidah, , M. Masnih, , A.A Affan Zahidi, , M. N. Khairunneezam,
Published: December 2017

Purpose: Nasheed is an art and media of da’wah in Islam. In Malaysia, the songs of da’wah and divine is always welcome although various genres of new music are present. This study aims to examine the relationship between da’wah and entrepreneurship by one of the famous nasheed group in Malaysia which is Inteam.

Methodology: This methodology of this study is qualitatively conducted where entrepreneurs were interviewed via open ended questions. The specialist informants and interviewers were the tools employed for data gathering purpose.

Main findings: This study help to understand the concepts of entrepreneurs and its relationship with da’wah. It is hoped that the findings of this study would add a larger knowledge about entrepreneurs especially among Muslim entrepreneurs in Malaysia.

Limitations: This study is focused on two persons those were interviewed, which are Mr. Muhammad Hazamin and Mr. Mohd Syahril at Inteam records, at Damansara Kuala Lumpur. Their feedback were quite good because those respondent perfectly answered the questions.

Implications of the study will be elaborated together with recommendations for future studies.

The originality in this studies is, it should introduce element of da’wah even doing a business to be a good Muslim.
O saber dos pescadores artesanais de Macaé (RJ): subsídios para a conservação e manejo dos recursos pesqueiros marinhos
Authors: Da Silva Evelyn Raposo , Fischer Luciano Gomes , Mincarone Michael Maia
Published: December 2017

O presente estudo avaliou o conhecimento etnotaxonômico dos pescadores artesanais do município de Macaé e inventariou as principais espécies de pescados marinhos de interesse comercial da região. Foram identificadas, científica e etnotaxonomicamente, 131 espécies correspondentes a 81 nomes populares monomiais e a 66 binomiais. Os resultados mostraram que o principal critério para identificação/classificação do pescado é baseado em características morfológicas; no entanto, critérios como ontogenia e habitat também são utilizados. O estudo concluiu que o conhecimento tradicional local constitui uma importante fonte de informação e deve ser considerado no processo de formulação de estratégias de manejo e conservação dos recursos pesqueiros.
Análise do Processo de Implantação do Sistema de Gestão Ambiental Baseado na NBR 14001 : Estudo de Caso de uma Cerâmica em Sobral/CE
Authors: Oliveira Gomes Janielle Santana
Published: December 2017

O aumento da preocupação com as questões ambientais e a limitação dos recursos naturais levaram a sociedade e o meio corporativo a ter atitudes diferentes, que minimizem os impactos ambientais negativos. O presente artigo tem o objetivo de relatar a implantação de um Sistema de Gestão Ambiental - SGA, em uma indústria de cerâmica vermelha na cidade de Sobral/CE. A metodologia se deu em estudo de caso, pesquisa qualitativa, documental, observações e entrevistas. Explanou-se sobre a importância do setor cerâmico para a economia tanto local quanto para o Brasil, mas levando em consideração, sobretudo, os impactos causados por sua atividade. A empresa possui um SGA baseado na norma ISO 14001, desenvolvendo ações ambientais de acordo com as exigências legais desde a década de 1980. A primeira prática adotada como programa de qualidade foi a política do 5S, posteriormente implementaram a produção mais limpa (P+L) com o objetivo de ser mais eficaz e reduzir os impactos. A empresa possui 1.466 hectares em área de manejo, de onde é retirada toda a lenha de sua produção. Entre as ações ambientais que a empresa realiza está a coleta seletiva, vista também como uma ação socioambiental, pois ela é parceira do Ecoelce.
Comparison of The Number of Macrophage in Full Thickness Wound Incision between Merremia mammosa Extract Treatment and NaCl in Male Wistar Rats
Authors: Hidayat Fajar Kurniawan , Elfiah Ulfa , Sofiana Kristianningrum Dian
Published: December 2017

The incidence of diabetes mellitus in Indonesia continues to increase. There are some complications in the diabetic condition, one of which is diabetic ulcer. Diabetic ulcers in diabetes patient can increase the risk of amputation and expensive treatment costs, so the alternative treatmeant such as Merremia mammosa wich has antiinflamatory and antidiabetic is needed. This study aimed to determine the comparison of the number of macrophage in the incisional wound in hyperglycemic male wistar rats between treatment with Merremia mammosa extract and NaCl. The in vivo test was done by creating wound incision on the mice backs and treated with gentamycin ointment 5% in a positive control group, NaCl in a negative control group and Merremia mammosa extract in a dose of 100m), 200mg, 400mg in treatment group. The result obtained by counting the number of macrophage in histopatholgy examination. The result showed the number of macrophage were 0,36 cells/field of view in a negative control group, 0,52 cells/field of view in a positive control group, 0,48 cells/field of view in all Merremia mammosa treatment groups. The data analysis showed no significant difference with p-value of 0,729. In conclusion, there was no significant difference between the used of Merremia mammosa extract and NaCl on full thickness incisional wounds of hyperglycemic male wistar rats. Keywords: Diabetes Mellitus, Merremia mammosa extract, incisional wound
Leptin Inhibit the Effect of Pioglitazone in Reducing MMP-9 and MMP-13 of IL-1β-Induced Chondrocytes
Authors: Normasari Rena , Murniati Anis
Published: December 2017

Osteoarthritis (OA) is the most common cause of joint pain, but there’s still no satisfying treatment that can inhibit degradation of articular cartilage in OA. One approach that is being widely studied is through activation of PPAR-γ. Many studies have shown effect of PPAR-γ on OA either in vitro or in vivo in animal model. On the other hand, the main risk factor of OA is obesity. Obesity generally followed by increased of leptin level due to leptin resistance. The aim of this study is to examine the effect of pioglitazone as PPAR-γ agonist in reducing the level of MMP-9 and MMP-13 in OA chondrocyte with hyperleptinemia. MMP-9 and MMP-13 are key role enzymes that degrades cartilage in OA. This study use IL-1β-induced chondrocyte exposed to pioglitazone. Pioglitazone 0,1μM, 1μM, and 10μM reduce MMP-9 and MMP-13 level. Whereas pioglitazone together with leptin 10μg/ml reduce the decrease level of MMPs compared to the group without leptin. Leptin inhibit the effect of pioglitazone in reducing the level of MMPs.Keywords: OA, leptin, pioglitazone, MMP-9, MMP-13
The Correlation between Service Quality of Maternal and Child Healthcare/Family Planning Clinic and Degree of Maternal and Child Health at Two Primary Health Care Centers in Jember
Authors: Makayasa Putri Kunthi Kencana , Wiji Astuti Ida Srisurani , Sugiyanta Sugiyanta
Published: December 2017

The high Maternal Mortality Rate (MMR) and Infant Mortality Rate (IMR) is still a major health problem in Indonesia. As an one of indicator to assess the quality of maternal and child healthcare is MMR and IMR. Service quality consists of five dimensions i.e., tangible, responsiveness, reliability, assurance, and empathy. The aim of this research was to determine the correlation between service quality of maternal and child healthcare/family planning polyclinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. This research used cross-sectional design with 144 respondents. Service quality was measured using ServQual questionnaire and degree of maternal and children health were measured using MMR and IMR. The results of statistical test with Spearman correlation test showed that the significance (p) = 0.000 and correlation coefficients (r) = 0.690. Thus, it can be concluded that there were a strong correlation between service quality of maternal and child healthcare/family planning clinic and degree of maternal and child health at Two Primary Health Care Centers in Jember. Keywords: Maternal Mortality Rate, Infant Mortality Rate, ServQual.
The Selectivity of Ethanolic Extract of Buah Makassar (Brucea javanica) on Metastatic Breast Cancer Cells
Authors: Sutejo Ika Rahmawati , Putri Herwandhani , Meiyanto Edy
Published: December 2017

Treatment of cancer such as surgery, radiotherapy and chemotherapy has many side effects. Chemopreventive agent is needed to reduce the side effect and increase the effectivity of therapy. The discovery of cochemopreventive agent should consider on its selectivity to reduce side effects. The selective cochemopreventive agents work effectively in cancer cells and safe for normal cells. Buah Makassar (Brucea javanica) is a natural product that is empirically used for anti-inflammatory and antitumor. The purpose of this study is to determine the cytotoxic effect of ethanolic extract of buah Makassar against 4T1, MCF7, HeLa, and Vero cell lines. The cytotoxic test is performed by MTT assay. The parameter obtained from the cytotoxic test was IC50. Selectivity index is determined from IC50 ratio of cancer cells to normal cells. The results showed that ethanolic extract of buah Makassar has a cytotoxic activity on 4T1, MCF7, HeLa, and Vero cells with IC50 were 49,9±0,83 μg/mL; 107,6±8,14 μg/mL; 228,9±4,16 μg/mL and 395,5± 4,21 μg/mL respectively. It also has high selectivity on 4T1 metastatic breast cancer cell with selectivity index of 7,93. It can be concluded that the ethanolic extract of buah Makassar has potential to be delevoped as cochemopreventive agent especially on metastatic breast cancer. Keywords: Brucea javanica, MTT assay, selectivity index, 4T1, MCF7, HeLa, Vero
The Effect Of Mefenamic Acid On Longitudinal Development Of Growth Plate In Young Male White Rats
Authors: Hasan Muhamad
Published: December 2017

The past epidemiologic studies did not have definite explanation about the effect of consuming Mefenamic Acid on Longitudinal Bone Development. The aim of this study is to explain the effect of Mefenamic Acid on Longitudinal Bone Development. The design of this study was the Separate pretest, Posttest Only Control Group Design using 40 male wistar strain rats and divided into four groups. They consists of one pretest group, one control group and two treatment groups. The treatment groups were given mefenamic acid orally in the dose of 27 mg/200 g BW/day, and 54 mg/200 g BW/day which were dissolved in 2 ml of distilled water. After 4 weeks, the length of femur, length of growth plate and number of longitudinal cell of growth plate are noticed. The result was showed in all of experimental animals had a significant difference to control groups (p<0.05). Pair wise comparisons showed that significant difference (p<0.05) occurred in all of groups except between mefenamic acid 27 mg and mefenamic acid 54 mg that not significant difference. This study show that mefenamic acid treatment cause decrease of femur length, decrease of growth plate length and decrease number of growth plate cell. Keywords: mefenamic acid, chondrocyte, growth plate
Antibacterial Activity of Ethanolic Extract from Tempuyung Leaf (Sonchus arvensis L.) againts Salmonella typhi by In Vitro Study
Authors: Yanuarisa Rinda , Agustina Dini , Santosa Ali
Published: December 2017

Tifoid fever caused by Salmonella typhi (S. typhi) is endemic disease in Indonesia. S. typhi begin to resist to chloramphenicol, so it is necessary to study about natural material as traditional medicine such as tempuyung. The aim of this research was to study antibacterial activity and Minimum Inhibitory Concentration (MIC) of ethanolic extract from tempuyung leaf (Sonchus arvensis L.) againts growth of S. typhi. This research used quasy experimental methods with post test only control group design. Treatment consisted of 8 concentrations with 5 replications was 2,5 µg/disc, 5 µg/disc, 10 µg/disc, 20 µg/disc, 30 µg/disc, 40 µg/disc, 60 µg/disc, and 80 µg/disc. As much as 10 µl from each concentration was dropped into disc and placed in Mueller Hinton Agar. Then incubated for 18 hours to 37oC. Observation of bacterial inhibition zone by using a caliper. Result of this research that the leaf extract at a concentration 10 µg/disc, 20 µg/disc, 30 µg/disc, 40 µg/disc, 60 µg/disc, and 80 µg/disc can inhibit the growth of Salmonella typhi. Minimum Inhibitory Concentration of ethanolic extract from tempuyung leaf was 10 µg/disc qualitatively and 4,43 µg/disc quantitatively. Key words: Sonchus arvensis L., Salmonella typhi, antibacterial
Study of Kidney Repair Mechanism of Cassava Leaf Extract on Gentamicin induced Nephrotoxicity
Authors: Normasari Rena , Dewi Rosita , Rachmania Sheilla
Published: December 2017

Drugs consumption like gentamicin caused damage and decreased of kidney function. Cassava leaf contain lots of micronutrients, such as vitamin C, vitamin A and carotenoids, which also as an antioxidant. The results of the study conducted by Almashuri proved that cassava leaf have high levels of carotenoid compounds. The purpose of this study was to determine the effect of cassava leaf extract on the repairment of renal damage in mice in vivo. This research is true experimental using mice (mus musculus) and were grouped into 5 groups. Two control groups (positive and negative) and 3 treatment groups (cassava leaves 150, 300, and 450 mg / day). Gentamicin is given every day for 14 days and then observed on serum levels of creatinine along with histopathological scores of kidneys’ damage. Statistical analysis showed a significant reduction in serum levels of creatinine (P <0.05) and a significant decrease in renal histopathologic score. This study suggests that cassava leaf extract can repair kidney damage as a result gentamicin-induced nephrotoxicity in mice.Keywords: cassava leaf extract, creatinin, kidney histopathology
Effectiveness Test of Basil Leaf (Ocimum basilicum) Extract As Bioinsecticide In Mosquito Coil to Mosquito Aedes aegypti Death
Authors: Ramayanti Indri , Layal Kamalia , Pratiwi Putri Utami
Published: December 2017

Aedes aegypti is the vector of Dengue Haemorhagic fever. One of the method to prevent the spread of dengue fever is vector control. Principal activity to control this vector might decrease their population as transmitter of disease. One way of controlling mosquitoes vectors is using a bioinsecticide from basil leaf. Basil leaf extract has bioinsecticide effect to Aedes aegypti because basil leaf has some active compounds, such as Flavonoid, Saponin, Tannin and essential oils. These compound are toxic to mosquitoes. The purpose of this study was to determine the effectiveness of basil leaf (Ocimum basilicum L.) extract as mosquito coil against Aedes aegypti. The design of this study is xperimental study with 450 subjects of Aedes aegypti. Subjects were divided into six groups. They were 0% (negative control), 25%, 50%. 70%, 90% extract and Transfluthrin 0,03% (positive control). Each group contained 25 mosquitoes. Observation were carried out for 60 minutes with 10 minutes intervals and three times of repetition. The Data were analyzed by probit to calculate the value of Lethal consentration. The result of Probit Analyze showed that LC50 was at a concentration of 41,81% and LC90 was at concentration of 101.66%. The results showed that the extract of basil leaf (Ocimum basilicum L.) effective as Aedes aegypti bioinsecticide in mosquito coil.
The Effect Of Folic On Different Dosage Level Against Retina Destruction Level Of Mice With Peroral Methanol 50%
Authors: Darma Putra I Gusti Ngurah Agung , Munawir Al , Sugiyanta Sugiyanta
Published: December 2017

In recent years, there are many methanol poisoned cases. Methanol poisoned cause of blindness, CNS problem, and metabolic acidosis. Folic acid is the one of many medicinal treatment for methanol poisoned. Folic acid has important role on methanol metabolism in our body. The aim of the study was to known the effect of addition folic acid on retina damage level of methanol poisoned. The method is experimental laboratories (true experiment design) with post test only control group design. The study included 5 separate test. The subject were mice which in 2 - 3 months age and had weight about 25 - 35 gr. There were 5 groups subject in the study. There were control group which given usual meals for mice and aquadest, negative control group which given methanol 7gr/ kgBW, treatment group 1,2, and 3 were given methanol 7gr/kgBW and folic acid 1 mg/kg BW, 3mg/kgBW, and 5 mg/kgBW. The treatment was given about 24 hours, then the eyes of the mice were taken to made blood smear. Damage of eyes were evaluated based score determined before. It can be concluded that addition folic acid can reduce retina damage level of metanol poisoned.
Nutrition Counseling on Group of First Thousand Days Of Life Effectively Improved Nutrition Awareness Knowledge and Attitude
Authors: Marchianti Ancah Caesarina Novi , Sakinah Elly Nurus , Diniyah Nurud
Published: December 2017

Nutrition status in the first thousand days of life (FTDL) of 270 days during pregnancy and 730 days in the infant's first life is a critical period, since the resulting consequences are permanent and irreparable. There are still many problems in the group of FTDL around the campus of University of Jember which require intensive handling, such as stunting, low energy protein, anemia, underweight and etc. Methods of improving the quality of nutrition for the FTDL group can be done by increasing knowledge about nutrition through counseling by utilizing various media (posters, brochures, videos, demos and presentation slides). This study aims to determine how far is the effectiveness of nutrition counseling in improving knowledge and attitude awareness on nutrition problems. The method used was to give counselling on nutrition in the target groups (members of Posyandu Catleya A and B) and assessed changes by comparing the level of nutritional knowledge and attitude before and after receiving counseling. The results showed there were significant differences in the level of nutritional knowledge and attitude between before and after the counseling about nutrition and food processing technology. It can be concluded that this method is quite effective to raise awareness of FTDL group on nutrition problems.

Keywords: food insecurity, nutrition counseling, nutrition awareness
Correlation Analysis of Food Consumption Pattern that Induced Hypertension on Farmer in Rural Areas of Jember Regency
Authors: Astuti Ida Srisurani Wiji
Published: December 2017

Food consumption pattern has been suspected as a factor that cause hypertension, whereas other than that it may also induced by another life style. Farmers’ hypertension prevalence is growing up in rural areas. This fact shows that the activity of farm as heavy as how farmers facing their problem in daily live. The aim of the study is explaining how the food consumption pattern of farmers induced hypertension meanwhile they are living in the rural areas, as the firsthand customer of the fresh product from farming and agroindustry. An observational analytic study by using asymmetry association of lambda was conducted to prove the correlation between hypertensive pattern consumption and prevalence hypertension of farmers. One hundred respondents (from Mayang and Ledokombo districts) were given food frequency questionnaire. The results showed the food pattern with high level of cholesterol, dairy milk and the product of it and using high mono sodium glutamate,were having a significant level of p value (< 0,05). It means there are strong correlation between them to hypertension prevalence.

Keywords: farmer, consumption pattern, hypertension
Comparison of the Effectiveness of 10% Sulfur Soap and 2-4 Ointment as Single Treatment
Authors: Zaelany Alief Ilman , Astuti Ida Srisurani Wiji , Sutejo Ika Rahmawati
Published: December 2017

Scabies disease caused by Sarcoptes scabiei var. hominis mites has become a problem in a whole world especially in developing countries like Indonesia. Scabies has a very contagious nature especially in places with dense population levels like Islamic boarding school. Permethrin which is a drug of choice for scabies has a fairly expensive price so it is less effective when used in mass treatment. In Indonesia, sulfur preparations, especially 10% sulfur soap and 2-4 ointment are easy to obtain because the price is affordable and available at the community health clinic. The purpose of this study is to know the difference in effectiveness of 10% sulfur soap and 2-4 ointment as a single treatment and combination on scabies disease. In this clinical trial study, treatment was performed on 3 groups, 10% sulfur soap group (n=36), 2-4 ointment group (n=36) and combination group (n=36). The examination was done on days 8, 15 and 22. Data analysis using SPSS version 23 with chi-square test. The results showed that the highest recovery rate was in combination group (week-1 (22,22%), week-2 (63,89%) and week-3 (94,44%)) followed by 2-4 ointment group (week-1 (11,11%), week-2 (72,22%) and week-3 (88,89%)) and 10% sulfur soap group (week-1 (2,78%), week-2 (52,78%) and week-3 (75,0%). The results of the analysis comparing the 10% sulfur soap group with the combination group showed p value on all consecutive examinations p=0,013, p=0,339 and p=0,022. In the comparison 2-4 ointment group to the combination group obtained p value on all examinations respectively p=0,206, p=0,448 and p=0,394. The conclusion is combination therapy had the highest cure rate and statistically significant (p=<0,05) was obtained in comparison of 10% sulfur soap to combination at week-1 and week-3 examination.

Keywords: scabies, comparison of the effectiveness, 10% sulfur soap, 2-4 ointment, combination, Islamic boarding school
The role of Cholecalciferol in the Improvement of Insulin Resistance in Diabetic Mice Model
Authors: Sakinah Elly Nurus
Published: December 2017

Insulin resistance is an important predictor of the incidence of diabetes mellitus. Vitamin D deficiency is one of the risk factors for insulin resistance, and there is a relationship between hypovitaminosis vitamin D with the prevalence of diabetes mellitus. Cholecalciferol is one form of vitamin D3. HOMA-IR levels are one of the parameters of insulin resistance. This study aims to prove that administration of cholecalciferol can improve insulin resistance conditions in diabetic mice model. This study used 20 mice divided into 5 groups negative control(STZ+propilen glycol), positive control (STZ+metformin), P1(STZ+cholealciferol 25ng), P2(STZ+cholealciferol 50ng), P3(STZ+cholealciferol 100ng). Mice given STZ dose 150mg / KgBB intraperitoneal to obtain hyperglycemia conditions. Administration of cholecalciferol for 14 days. The result obtained average HOMA-IR level after treatment is negative control(2,32), positive control (0,825), P1(0,975), P2(0,5), P3(0,3). The result obtained average HOMA-B level after treatment is negative control (2,76), positive control (11,92), P1 (18,4), P2(10,88), P3(35,35). The result of statistical analysis using Kruskall wallis test obtained p <0,005. The conclusion of this study is that administration of cholecalciferol may improve insulin resistance in diabetic model mice.

Keyword : cholecalciferol, HOMA-IR, HOMA-B, streptozotocin
Syzygium Samarangense Leaves Ointment Enhances Wound Healing Process Of Skin Burn Based On Collagen
Authors: Insani Ain Yuanita , Prameswari Mega Citra , Muharrom Novail Alif , Hidayati Toyibatul , Nugrahani Arista Prima , Sakinah Elly Nurus
Published: December 2017

Background: The World Health Organization (WHO) estimates the number of death in 2014 caused by burns is 265,000. Burns can caused skin damage as well as other complication problems such as dehydration, infection, and other multiple organ failures. Syzygium samarangense leaves contain flavonoids and saponins that can increase the activation of macrophages and TGF-B which is important to accelerate the process of collagen formation and wound healing process. Objective: Knowing the effect of Syzygium samarangense leaf extract on the healing process of burn based on collagen. Method: This in vivo study use true experimental design. We made burns by placing a coin that already heated in oven at 70ºC for 10 seconds. Rattus Wistar as experimental animals dividedinto 6 groups (n = 4) with details of Group A (normal), B (positive), C (negative). Groups D, E, and F were the groups that given ointment extract topically in doses of 15%, 30%, and 45% each day’s. Termination is done on day 7. Test statistics by using Anova and Kruskal Wallis. Results and discussion: From this research, Syzygium samarangense leaf extract can reduce the wound area (p <0,05) and increase the amount of collagen (p <0,05). Conclusion: Syzygium samarangense leaf extract ointment can accelerate the healing process of burns.

Keywords : Burns, Syzygium samarangense Leaves ointment, Saponin, Flavonoid, Collagen
Effect Artificial Rice Diet Administration to Coronary Artery Histopathology of Rat Model Type 2 DM
Authors: Roosyidah Monika , Efendi Erfan , Hairrudin Hairrudin
Published: December 2017

The most common macrovascular complication of type 2 DM’s patiens is coronary artery disease caused by coronary artery stricture or spasm or both of them. The atherosclerosis process in coronary artery can be seen through coronary artery histopathology of rat. DM can be controlled so that the complication can be prevented, for example by controlling diet. Artificial rice with high fiber is one of breakthrough for DM patients diet. The purpose of this research is to know about the effects of artificial rice diet administration to coronary artery histopathology of rat model type 2 DM. Rats are divided to four groups consist of control normal group given standart feeding, PBA1;PBA2;PBB group are inducted by high fat diet and low dose STZ so that they become rat model type 2 DM. Since PBA1 is feeded by formula 1 artificial rice, PBA1 is feeded by formula 2 artificial rice and PBB is feeded by common rice. Rats are terminated and their hearts are taken away to make histopathology object and their coronary artery are seen under light microscope. Histopathology images are based on foam cell formed. Kruskal-Wallis’s result shows that p= 0,046 (p<0,05), so that there is a significant difference between groups.Keywords : DM, atherosclerosis, foam cell, coronary artery histopathology
Development and validation of a fast, simple, cost-effective and robust HPLC method for lisinopril determination in solid pharmaceutical dosage forms
Authors: Bakovska Stoimenova Tanja , Piponski Marjan , Trendovska Serafimovska Gordana , Stefova Marina
Published: December 2017

A fast, simple, cost-effective and robust chromatographic method was developed and validated for determination of the antihypertensive drug lisinopril dihydrate in tablets under routine operational conditions, without ion-pair reagents, high column temperatures and an acidic mobile phase. Taking into consideration all four different pKa values of lisinopril, the separation was optimized using the C18 column (end-capped, 150 mm × 4.6 mm 5 µm) and a mobile phase composed of methanol and ammonium (or potassium) dihydrogen phosphate buffer (pH 7.2) with a flow rate of 1.1 ml/min, UV detection at 214 nm and a temperature of 40 °C. These optimized conditions led to the production of a single and symmetrical peak for lisinopril. This mobile phase is suitable for different HPLC columns, which makes it appropriate for industrial quality control laboratories. The developed method was validated, showing excellent validation results and the possibility to be implemented for the determination of lisinopril in combined dosage forms with other active substances.
Identifikasi Komponen Kimia pada Umbi Bentul (Colocasia esculenta (L.) Schoot) sebagai Pangan Fungsional
Authors: Fidyasari Ambar , Sari Rizky Mayang , Raharjo Sentot Joko
Published: December 2017

Background: Nowadays tubers are mostly explored to determinetheir essential components. Colocasia esculenta (l.) Schottis one of tubers that its use has not been maximally explored. Objective: This research aims to identify the chemical components onColocasia esculenta (l.) Schott. Methods: The research stages include, first, the determination for finding out the right plant; second, the preparation and implementation (including theflour preparation andits proximate testing asthe carbohydrate, protein, fat, carbon, moisture and fiber testing); third, the flour extraction for obtaining the PLA and its PLA analysis using HPLC. Results: The result shows the chemical components of protein is 3.45%, fat is 0.31%, moisture is 6.07%, carbon is 2.14%, carbohydrate is 88.03%, and fiber is 2.87%. The yield extraction results are 2.9% and 9.0%. Conclusion: The flour extraction analysis displays polysaccharide proven by the presence of DP and DP5 of 72.356% and 87.98%. However,its sugar molecule composition has not been identified yet.ABSTRAK Latar belakang: Umbi-umbian saat ini mulai banyak dieksplorasi untuk mengetahui komponen penting yang terdapat dalam umbi tersebut. Umbi bentul salah satu umbi yang pemanfaatan belum dieksplorasi secara maksimal.Tujuan: dari penelitian ini adalah untuk mengetahui komponen kimia yang terdapat dalam bentul. Metode: Tahapan penelitian ini meliputi  pertama,  tahap determinasi untuk mengetahui kebenaran tanaman yang akan digunakan. Kedua, tahap persiapan serta pelaksanaan meliputi proses pembuatan tepung bentul, pengujian mutu kimia atau proksimat tepung meliputi karbohidrat, protein, lemak, kadar abu, kadar air dan serat. Ketiga, ekstraksi tepung untuk mendapatkan senyawa yang diduga PLA dan analisanya dengan menggunakan HPLC.Hasil: Berdasarkan penelitian menunjukkan hasil komponen kimia protein 3,45%, lemak 0,31%, air 6,07%, abu 2,14%, karbohidrat 88,03%, dan serat 2,87%. Rendemen hasil ekstraksi tepung yaitu 2,9% dan 9,0%.Kesimpulan : Analisa dari ekstrak tepung terbukti mengandung polisakarida dengan adanya DP dan DP5 memiliki total 72,356% dan 87,98% namun belum diketahui jenis gula penyusunnya.
Perbedaan Kadar Hemoglobin, Asupan Zat Besi, dan Zinc pada Balita Stunting dan Non Stunting
Authors: Losong Nathania Helsa F. , Adriani Merryana
Published: December 2017

Background: Stunting is a chronic nutritional problem in children cause growth retardation which caused by poor parenting and inadequate intake. Low intake of macro nutrient and micro nutrient can affect to stunting in toddler. Intake of iron and zinc affect the incidence of stunting because iron and zinc affect growth hormone. In addition, low iron intake can affect hemoglobin levels in the body Objectives: The purpose of this study was to analyze the differences of hemoglobin level, iron and zinc intake in stunting and non stunting toddler. Methods: The research was an observational analytic with cross sectional design. The sample of this study were 42 toddler12-24 months in Tambak Wedi Public Health Center, Kenjeran  Sub-district, Surabaya, 21 toddler each stunting and non stunting. The data were collected by measuring height, food recall 2x24 hours, and blood sampling for hemoglobin measurement with cyanmethemoglobin method. The data were analyzed using chi square test and fisher test. Results: The result of this study showed there was difference of hemoglobin level (p=0.009), iron intake (p=0.004), and zinc intake (p=0.000) Conclusion: Stunting toddler have a lower hemoglobin level, iron and zinc intake more than non stunting toddler. Mother of toddler should have to increase the variant food source iron and zinc to prevent stunting in the future. ABSTRAK Latar belakang: Stunting merupakan masalah gizi kronis pada anak-anak yang menyebabkan terganggunya pertumbuhan linear anak dan diakibatkan oleh pola asuh dan asupan yang rendah.Rendahnya asupan zat gizi makro maupun mikro dapat mempengaruhi kejadian stunting pada balita. Asupan zat besi dan zinc dapat mempengaruhi kejadian stunting karena zat besi dan zinc mempengaruhi hormon pertumbuhan. Selain itu, asupan zat besi yang rendah dapat mempengaruhi kadar hemoglobin dalam tubuh. Tujuan: Menganalisis perbedaan kadar hemoglobin dan asupan zat besi serta zinc dari makanan pada balita stunting dan non stunting.Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain cross sectional. Sampel terdiri dari 42 balita berusia 12-24 bulan di wilayah Kerja Puskesmas Tambak Wedi Kecamatan kenjeran Surabaya, balitastunting dannonstunting masing-masing sebesar 21 sampel.Pengumpulan data menggunakan pengukuran tinggi badan, food recall 2x24 jam, dan pengambilan sampel darah untuk pengukuran kadar hemoglobin menggunakan metode cyanmethemoglobin. Data dianalisis menggunakan chi square test dan fisher test.Hasil: Hasil dari penelitian ini adalah terdapat perbedaan kadar hemoglobin (p=0,009), asupan zat besi (p=0,004), dan zinc (p=0,000) pada anak stunting dan non stunting.Kesimpulan: Balita stunting memiliki kadar hemoglobin dan asupan zat besi dan zinc yang lebih rendah daripada balita non stunting. Ibu balita sebaiknya meningkatkan variasi asupan sumber zat besi dan zinc agar dapat mencegah terjadinya stunting di masa yang akan datang.
Pola Konsumsi Makanan Sumber Yodium dan Goitrogenik dengan GAKY pada Anak Usia Sekolah di Ponorogo
Authors: Izati Imaniar Mahdiya , Mahmudiono Trias
Published: December 2017

Background: Iodine deficiency disorders (IDD) is one of nutritional problem in Indonesia. Inadequate intake of iodine and excessive goitrogenic intake is are main cause of IDD. Objectives: This study aimed to determine factors associated with IDD among schoolchildren. Methods: This study was an observational analytic with case control design in Sidoharjo Village, Jambon Sub District, Ponorogo on May 2017. The sample was 62 students from the first – sixth grade of SDN IV Krebet. They are consist of 31 students suffer IDD and 31 students with non IDD measured from goiter palpation. The data was collected by interview using questionnaire, iodine and goitrogenic consumption using FFQ. Data were analyzed by using chi square, fisher exact, spearman correlation and logistic regression. Results: Dietary iodine source that are rarely consumed is seafood (79,03%). Dietary goitrogenic source that are often consumed is tiwul (48,39%). Logistic regression analysis showed that seafood intake is the most influence factor of IDD (p= 0,011). Conclusion: There was a relation between iodine intake and goitrogenic intake with IDD among school children. Meanwhile, there is no association between characteristic of family with IDD among school children.ABSTRAK Latar Belakang: Gangguan Akibat Kekurangan Yodium (GAKY) merupakan salah satu masalah yang ada di Indonesia hingga saat ini. Rendahnya asupan yodium dan tingginya konsumsi sumber goitrogenik adalah penyebab terjadinya GAKY.Tujuan: Untuk mengetahui faktor yang berhubungan terhadap kejadian GAKY pada anak usia sekolah.Metode: Penelitian ini merupakan penelitian observasional analitik dengan desain case control dan dilakukan di Desa Sidoharjo, Kecamatan Jambon, Kabupaten Ponorogo pada bulan Mei 2017. Sampel penelitian ini yaitu siswa SDN IV Krebet dari kelas I-VI yang terdiri dari 62 siswa dimana 31 siswa menderita GAKY dan 31 siswa tidak menderita GAKY yang didapatkan dari hasil pemerikasaan palpasi. Pengumpulan data dilakukan menggunakan metode wawancara dengan kuesioner dan FFQ untuk mengetahui pola konsumsi makanan sumber yodium serta goitrogenik. Data dianalisis menggunakan chi square, fisher exact, korelasi spearman dan regresi logistik.Hasil: Makanan sumber yodium yang jarang dikonsumsi oleh responden adalah ikan laut (79,03%). Sedangkan makanan sumber goitrogenik yang sering dikonsumsi oleh responden adalah tiwul (48,39%). Hasil uji regresi logistik menunjukkan bahwa faktor yang paling berpengaruh terhadap kejadian GAKY yaitu pola konsumsi ikan laut (p= 0,011).Kesimpulan: Terdapat hubungan antara pola konsumsi ikan laut, pola konsumsi telur dan pola konsumsi tiwul dengan kejadian GAKY. Sebaliknya tidak terdapat hubungan antara karakteristik keluarga dengan kejadian GAKY.
EFFECTIVITY AND RENAL SAFETY OF CYCLOSPORINE AND METHYLPREDNISOLONE COMBINATION THERAPY IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)
Authors: Wuryana Desantika , Suryana Bagus PP , Yulistiani Yulistiani
Published: December 2017

Cyclosporine and methylprednisolone combination are second line therapy for moderate to severe systemic lupus erythemathosus. Some study suggest that the combination were effective to decrease of systemic lupus erythematosus disease activity. But record from the study, cyclosporine cause nephrotoxicity side effect. Therefore, this study should be considered to monitore therapy effect on disease activity and renal side effect. The aim of this study is to analyze the effect of cyclosporine and methylprednisolone combination therapy on disease activity in systemic lupus erythematosus (SLE) assessed by MEX-SLEDAI and renal side effect assessed by creatinine, ureum and proteinuria. A cohort, observational prospective study was conducted to determine the effect of cyclosporine and methylprednisolone combination therapy on disease activity of SLE and renal side effect of this combination. Patients who met criteria were given cyclosporine and methylprednisolone combination that normally renal function tests. MEX-SLEDAI score, creatinine, ureum and proteinuria were measured for fourth times (one time in one mounth), before study, 1st mounth, 2nd mounth, and 3rd mounth. The study comprised 9 patients SLE were given cyclosporine and methylprednisolone combination that normally renal function tests. All patients were female and had productive age. At 3rd mounth, there was increase patients who had MEX-SLEDAI score <2 (55,6%) and one patient (11,1%) had increase of creatinine, ureum and proteinuria. In conclusion, cyclosporine and methylprednisolone combination therapy showed the effectiveness and safety in 88,9% patients and renal dysfunction in 11,1% patients.
ANALYSIS OF HOMA-IR, FOLLICLE SIZE, AND ESTRADIOL AFTER COMBINATION THERAPY OF METFORMIN AND CLOMIPHENE CITRATE IN POLYCYSTIC OVARY SYNDROME’S PATIENT
Authors: Dzykryanka Sylvy Medtasya , Yulistani Yulistani , Santoso Budi
Published: December 2017

PCOS is an ovarian dysfunction syndrome which characterized by the present of unovulation, hyperandrogenism, and polycystic ovarian morphology. The main cause of PCOS is still unclear, but many studies report that genetic factor have a great role. There are also two big concept in PCOS, hyperandrogenism and insulin resistance. Previous research by Ayaz et al (2013) has shown that metformin was given if there has been a resistance of clomiphene citrate. This study was designed to provide metformin and clomiphene citrate combination from the early administration to determine the effectiveness of the combination therapy. The objective of this study is to analyze HOMA-IR value, follicle size, and estradiol concentration after metformin and clomiphene citrate treatment in PCOS patient. Design of this study was an observational longitudinal prospective method. There was only a group with a total sample size 19 women of productive age (18-40 years) diagnosed with PCOS. The pre and post combination therapy was observed for ten weeks. Metformin 500 mg three times daily for ten weeks and clomiphene citrate 100 mg in 3rd day until 7th day of menstruation for two cycles were given to the subjects. The result showed that HOMA-IR value decrease after 10 weeks in which value before therapy was 4.9 ± 2.4 and after therapy 3.7 ± 2.2 with the achievement 21.1% HOMA-IR under 2.5. Estradiol concentration after therapy also decreased from 64.8 ± 24.7 pg/ml to 37.9 ± 17.9 pg/ml in ten weeks this concentration remained the range of the follicular phase estradiol levels. On the other hand, follicle size increased from 4.7 ± 0.6 mm to 10.7 ± 2.2 mm after combination therapy of metformin and clomiphene citrate with the occurrence of ovulation 31.6% but none of the samples were successfully pregnant. It is concluded that women with PCOS, declined HOMA-IR, estradiol, and increased follicle size was associated with a good response to combination therapy of metformin and clomiphene citrate.