bluuebunny/crossref_metadata_2025 huggingface dataset:
BOOK CHAPTER PENGANTAR PENDIDIKAN
Authors: Amirudin  , Saputra Dani Nur , Ariningsih Kadek Ayu , Wau Maria Patrisia , Noviyani Rafiqa , Awe Ermelinda Yosefa , Firdausiyah Luluk
Published: September 2021

Book Chapter Pengantar Pendidikan disusun untuk kepentingan sebagai buku pegangan yang diikhtiarkan untuk membantu para mahasiswa dan dosen yang menempuh mata kuliyah Pengantar Pendidikan, Belajar dan Pembelajaran, oleh karena itu buku ini berdasarkan dan dirumuskan sesuai dengan Rencana pembelajaran di Fakultas Keguruan dan Ilmu Pendidikan di semua Universitas atau IKIP yang berhubungan dengan Pendidikan. Secara tradisi di Indonesia mata kuliah Pengantar Pendidikan, Belajar dan Pembelajaran yang di berlakukan di Fakultas Keguruan dan pendidikan atau LPTK dapat disajikan pada semester awal atau semester dua yang mengawali sekaligus membekali para mahasiswa yang akan memepelajari dan mendalami tentang ilmu pendidikan. Pendidikan adalah merupakan sebuah proses perubahan sikap dan perilaku seseorang atau kelompok melalui sebuah sistem pengajaran dan pelatihan tertentu, tujuan pendidikan suatu bangsa di sesuaikan dengan kepentingan bangsa itu sendiri, pendidikan dapat kita implementasikan sebagai revolusi industri yang dapat merubah cara pikir dan tingkah laku sesuai dengan mdel pendidikan saat ini.
Factors Affecting Choice Of Health Care Facilities Among The Adults of an Urban Community
Authors: Shrestha Raksha , Adhikari Sarita
Published: September 2021

Introduction: Health service delivery systems that are safe, accessible, high quality, people-centred, and integrated are critical for moving towards universal health coverage. World Health Organisation is supporting to improve the efficiency and effectiveness of health service delivery systems to all the population not only the patients. This study aims to identify the factors affecting the choice of health care facilities among the adults of an urban community and its association with the selected socio-demographic variables. 

Methods: A descriptive cross-sectional study was conducted among the community residence with 120 respondents using non-probability purposive sampling technique. Data was collected using semi-structured interview schedule that was analysed by using descriptive statistical methods such as frequency, percentage, mean, standard deviation and inferential statistics such as chi-square test.

Result: The findings of the study revealed that majority (60.8%) of the respondents used private health care facilities and there was significant association of the choice of health care facility with the health care services related factors whereas no significant association was found with the selected socio-demographic variables.

Conclusions: Based on the study findings, it concluded that various health care services related factors like availability, affordability, acceptability and accessibility factors tends to affect the choice of health care facility
LIS Activities in Nepal : An Overview in prospect of DoLIA
Authors: Sapkota Ram Kumar
Published: September 2021

Modern age is the age of Information Communication Technology (ICT). Every sectors are enhancing their performance, capacity and quality of job through the use of ICT. So implementing Information Communication Technology in the field of Land Administration is highly essential. Indeed it’s a need of time. On this way, in our context DoLIA is vigorously working on modernizing land administration and approaching towards paper and pencil free land administration and establishing Land Information System (LIS) in Nepal with full effort and dedication with limited manpower and resources.
Curious Chloride (Cmcl3) and Titanic Chloride (Ticl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (Eppsi) Nano Molecules for Cancer Treatment and Cellular Therapeutics
Authors: Heidari Alireza
Published: September 2021

In the current study, we study Curious Chloride (CmCl3) and Titanic Chloride (TiCl4)–Enhanced Precatalyst Preparation Stabilization and Initiation (EPPSI) Nano molecules incorporation into the Nano Polymeric Matrix (NPM) by immersion of the Nano Polymeric Modified Electrode (NPME) as molecular enzymes and drug targets for human cancer cells, tissues and tumors treatment under synchrotron and synchrocyclotron radiations.
Role of Biorepositories in Personalized Medicine: Isolation and Processing of Primary Tumor Cells for the initiation Tumor Cultures
Authors: H Zhang , J Ma , J Wang , W Moore , Z Liang
Published: September 2021

The introduction of three-dimensional (3D) tumor cultures has revolutionized anticancer drug research as these cultures allow for the study of drug resistance mechanisms that cannot be explored in traditional two dimensional (2D) monolayer cultures. Discoveries in the 3D tumor culture field suggest that individualized drug sensitivity testing of solid tumor specimens through the establishment and use of 3D tumor cell cultures following tissue collection will become a routine service offered by modern tissue repositories as they expand from their traditional research role to active participation in personalized medicine. Unfortunately, most information related to 3D tumor cultures comes from studies using established tumor cell lines rather than primary tumor cultures. However, accumulation of genetic aberrations in cancer cell lines occurs with increasing number of passages severely limiting their usefulness for personalized medicine. There is only very limited information available concerning technologies and standard operating procedures for the efficient and routine isolation and processing of primary tumor cells for the establishment of 3D tumor cultures from solid tumor specimens. The purpose of this work was to review experimental data from the literature that may provide relevant information concerning the isolation and processing of primary tumor cells for the establishment of 3D tumor cultures. Information reviewed here may help bio repositories in the development and standardization of technologies and standard operating procedures related to the use of 3D tumor cultures.
Evaluate the response of Apoptosis, Angiogenesis and Cancer Therapies
Authors: Gayan Chathura
Published: September 2021

Angiogenesis, the growth of new blood vessels from the existing vasculature, and is maintained in adult tissues by the balanced presence of both angiogenic inducers and inhibitors in the tissue milieu. When inducers predominate, vascular endothelial cells (VECs) become activated and in this activated VECs, distinct cell signaling pathways are initiated providing the specificity of anti-angiogenic therapies to the tumor vasculature. VEC apoptosis has been well documented in regressing vessels, and it has been shown that, in addition to activating the VECs, some inducers such as vascular endothelial growth factor also up-regulate Fas expression, thus sensitizing the cell to apoptotic stimuli. Endogenous angiogenesis inhibitors, such as thrombospondin-1(TSP-1) and pigment epithelium-derived factor (PEDF), stimulate signaling cascades within the VECs and also induce the expression of Fas ligand in activated VECs. Therefore, when inhibitors predominate, the apoptotic cascade is initiated ,thus anti-angiogenic therapies can target the inducer supply or directly target the VECs. Although clinical studies suggest that anti-angiogenic therapies may prove to be most effective when used in combination with traditional therapies
Penanganan Risiko Keamanan Informasi Aplikasi Webmarket Berdasarkan ISO 27001:2013 (Study Kasus pada PT Sanjaya Citra Anugrah)
Authors: M. Hadi Prayitno
Published: September 2021

Sanjaya Citra Anugerah (SCA) adalah perusahaan yang bergerak dibidang sewa menyewa dan penjualan alat berat, memiliki komitmen untuk memastikan keamanan informasi organisasi untuk menjaga aspek kerahasiaan, integritas dan ketersediaan informasi dari ancaman kegagalan keamanan informasi. Hal tersebut diwujudkan dengan mengimplementasikan sistem manajemen keamanan informasi yang berdasarkan pada standar internasional ISO 27001:2013.

Penelitian ini bertujuan untuk mendeskripsikan ruang lingkup sistem manajemen keamanan informasi, faktor internal dan eksternal yang mempengaruhinya dan untuk mengidentifikasi secara garis besar potensi kegagalan keamanan informasi dan dampaknya. Potensi kegagalan tersebut, merupakan risiko yang harus di idetifikasikan berdasarkan kondisi saat ini, yang selanjutnya ditentukan penyebabnya hingga disusun rencana penanganan risiko dimaksud, sehingga keamanan informasi dapat terjaga dan pada akhirnya meningkatkan tingkat kepercayaan dari stakeholder.

Kata kunci : Keamanan Informasi, ISO 27001:2013, risiko
Implementasi Big Data Analytical Untuk Perguruan Tinggi Menggunakan Machine Learning
Authors: Purnomo Rakhmat , Wowon Priatna  , Tri Dharma Putra
Published: September 2021

The dynamics of higher education are changing and emphasize the need to adapt quickly. Higher education is under the supervision of accreditation agencies, governments and other stakeholders to seek new ways to improve and monitor student success and other institutional policies. Many agencies fail to make efficient use of the large amounts of available data. With the use of big data analytics in higher education, it can be obtained more insight into students, academics, and the process in higher education so that it supports predictive analysis and improves decision making. The purpose of this research is to implement big data analytical to increase the decision making of the competent party. This research begins with the identification of process data based on analytical learning, academic and process in the campus environment. The data used in this study is a public dataset from UCI machine learning, from the 33 available varibales, 4 varibales are used to measure student performance. Big data analysis in this study uses spark apace as a library to operate pyspark so that python can process big data analysis. The data already in the master slave is grouped using k-mean clustering to get the best performing student group. The results of this study succeeded in grouping students into 5 clusters, cluster 1 including the best student performance and cluster 5 including the lowest student performance
Pembangunan Aplikasi E-Magang Perguruan Tinggi dengan Memanfaatkan SDLC SCRUM pada Agile Project Management
Authors: Kustanto Prio , R. Wisnu P. Pamungkas  , Fathurrozi Ahmad
Published: September 2021

Higher Education facilitates the process of Internship students through several stages, which can be taken by students after fulfilling the requirements. The Process of Internship, starting with making an official letter of submission to the company where the internship is accompanied by the submission of proposals internships until the implementation of Internship Work in the company is completed. After the internship process is completed students then make a report Internship. Readiness of Study Program to the Faculty in managing the process of implementation of internship work vary. Especially readiness when the Study Program enrolls students until obtaining the scheduling of the seminar report Internship.

Universities that have fewer students may not be a problem. But if universities have a large number of Faculties and Study Programs, so the number of active students owned is also a lot, this can be the first step of the complexity of a system. The problems that arise are conflicting schedules of supervisors, examiners and rooms.

To facilitate the implementation of the process, e-Magang application is made to help the application process of Internship. The e-Internship application is built with the phase flow of the Scrum SDLC method in Project Management.
Problem synonimii wyrażeń inny niż_ i różny od_
Authors: Wołk Mariola
Published: September 2021

Przedmiotem badań w niniejszym artykule jest rodzaj relacji semantycznej, jaka zachodzipomiędzy dwiema jednostkami języka: inny niż_ i różny od_. Ponieważ uznawanie ichsynonimiczności wydaje się raczej powszechne, w rozważaniach tych podjęta została próbasfalsyfikowania tej hipotezy. W tym celu przywołane zostały zarówno argumenty za jejutrzymaniem (np. testy substytucji pokazujące możliwości zamieniania porównywanychprzymiotników w wielu kontekstach), jak i za jej odrzuceniem (np. ograniczenia nałożonena dystrybucję jednostki różny od_). W analizie uwzględnione zostały także propozycjedefiniowania obu wyrażeń w słownikach współczesnej polszczyzny. Ustalenia końcowezawierają rozstrzygnięcie badanego problemu oraz wstępne eksplikacje opisywanychjednostek.
Futbolculara Uygulanan Core Egzersizlerinin Bazı Motorik Özellikler Üzerine Etkisi
Authors: İRİ Ruçhan , ÖZTEKİN Burak , ŞENGÜR Emrah
Published: September 2021

Çalışmanın amacı futbolculara uygulanan core egzersizlerinin bazı motorik özellikler üzerine etkisinin incelenmesidir. Çalışmaya amatör futbol liginde oynayan 18-25 yaş arası 30 futbolcu gönüllü olarak katılmıştır. Futbolcuların BMI, VYY, sürat, dikey sıçrama, anaerobik güç ve aerobik performansları ölçülmüştür. Kontrol ve deney gruplarının ön test, son test ölçümleri arasındaki farklılığın belirlenmesinde Wilcoxon İşaretli Sıralar testi, ön test ve son test ölçümlerinin gruplar (kontrol-deney) arasındaki farklılığın belirlenmesinde Mann-Whitney U testi analizi kullanılmıştır. Kontrol grubunun ön test son test sonuçlarının karşılaştırılmasında cooper ve VYY değişkenlerinde fark olduğu tespit edilmiştir. Deney grubunun ön test son test karşılaştırılmasında cooper, 20 m sprint, dikey sıçrama, çeviklik, VYY ve anaerobik güç değişkenlerinde anlamlı fark tespit edilmiştir. Kontrol ve deney gruplarının ön test sonuçlarının karşılaştırılmasında dikey sıçrama ve anaerobik güç değişkenlerinde fark olduğu farkın deney grubu lehine olduğu tespit edilmiştir. Kontrol ve deney gruplarının son test sonuçlarının karşılaştırılmasında dikey sıçrama, anaerobik güç ve çeviklik değişkenlerinde gruplar arası karşılaştırılmasında fark olduğu, farkın deney grubu lehine olduğu tespit edilmiştir. Sonuç olarak, takım içerisinde kendi antrenman metotlarıyla yüklenmeler yapan futbolculara farklı egzersizler uygulandığında performans gelişiminin olumlu şekilde olacağı tespit edilmiştir. Belirli bir amaç doğrultusunda futbolcuların performansını arttırmak amacıyla yapılacak periyotlamalarda core egzersizlerinin kullanılması önerilmektedir.
Preoperative imaging patterns and intracranial findings in single-suture craniosynostosis: a study from the Synostosis Research Group
Authors: Ravindra Vijay M. , Awad Al-Wala , Baker Cordell M. , Lee Amy , Anderson Richard C. E. , Gociman Barbu , Patel Kamlesh B. , Smyth Matthew D. , Birgfeld Craig , Pollack Ian F. , Goldstein Jesse A. , Imahiyerobo Thomas , Siddiqi Faizi A. , Kestle John R. W. , _ _
Published: September 2021

OBJECTIVE

The diagnosis of single-suture craniosynostosis can be made by physical examination, but the use of confirmatory imaging is common practice. The authors sought to investigate preoperative imaging use and to describe intracranial findings in children with single-suture synostosis from a large, prospective multicenter cohort.

METHODS

In this study from the Synostosis Research Group, the study population included children with clinically diagnosed single-suture synostosis between March 1, 2017, and October 31, 2020, at 5 institutions. The primary analysis correlated the clinical diagnosis and imaging diagnosis; secondary outcomes included intracranial findings by pathological suture type.

RESULTS

A total of 403 children (67% male) were identified with single-suture synostosis. Sagittal (n = 267), metopic (n = 77), coronal (n = 52), and lambdoid (n = 7) synostoses were reported; the most common presentation was abnormal head shape (97%), followed by a palpable or visible ridge (37%). Preoperative cranial imaging was performed in 90% of children; findings on 97% of these imaging studies matched the initial clinical diagnosis. Thirty-one additional fused sutures were identified in 18 children (5%) that differed from the clinical diagnosis. The most commonly used imaging modality by far was CT (n = 360), followed by radiography (n = 9) and MRI (n = 7). Most preoperative imaging was ordered as part of a protocolized pathway (67%); some images were obtained as a result of a nondiagnostic clinical examination (5.2%). Of the 360 patients who had CT imaging, 150 underwent total cranial vault surgery and 210 underwent strip craniectomy. The imaging findings influenced the surgical treatment 0.95% of the time. Among the 24% of children with additional (nonsynostosis) abnormal findings on CT, only 3.5% required further monitoring.

CONCLUSIONS

The authors found that a clinical diagnosis of single-suture craniosynostosis and the findings on CT were the same with rare exceptions. CT imaging very rarely altered the surgical treatment of children with single-suture synostosis.
A multicenter analysis of the prognostic value of histone H3 K27M mutation in adult high-grade spinal glioma
Authors: Akinduro Oluwaseun O. , Garcia Diogo P. , Higgins Dominique M. O. , Vivas-Buitrago Tito , Jentoft Mark , Solomon David A. , Daniels David J. , Pennington Zach , Sherman Wendy J. , Delgardo Mychael , Bydon Mohamad , Kalani Maziyar A. , Zanazzi George , Tsankova Nadejda , Bendok Bernard R. , McCormick Paul C. , Sciubba Daniel M. , Lo Sheng-fu Larry , Clarke Jennifer L. , Abode-Iyamah Kingsley , Quiñones-Hinojosa Alfredo
Published: September 2021

OBJECTIVE

High-grade spinal glioma (HGSG) is a rare but aggressive tumor that occurs in both adults and children. Histone H3 K27M mutation correlates with poor prognosis in children with diffuse midline glioma. However, the role of H3 K27M mutation in the prognosis of adults with HGSG remains unclear owing to the rarity of this mutation, conflicting reports, and the absence of multicenter studies on this topic.

METHODS

The authors studied a cohort of 30 adult patients with diffuse HGSG who underwent histological confirmation of diagnosis, surgical intervention, and treatment between January 2000 and July 2020 at six tertiary academic centers. The primary outcome was the effect of H3 K27M mutation status on progression-free survival (PFS) and overall survival (OS).

RESULTS

Thirty patients (18 males and 12 females) with a median (range) age of 50.5 (19–76) years were included in the analysis. Eighteen patients had H3 K27M mutation–positive tumors, and 12 had H3 K27M mutation–negative tumors. The median (interquartile range) PFS was 3 (10) months, and the median (interquartile range) OS was 9 (23) months. The factors associated with increased survival were treatment with concurrent chemotherapy/radiation (p = 0.006 for PFS, and p ≤ 0.001 for OS) and American Spinal Injury Association grade C or better at presentation (p = 0.043 for PFS, and p < 0.001 for OS). There were no significant differences in outcomes based on tumor location, extent of resection, sex, or H3 K27M mutation status. Analysis restricted to HGSG containing necrosis and/or microvascular proliferation (WHO grade IV histological features) revealed increased OS for patients with H3 K27M mutation–positive tumors (p = 0.017).

CONCLUSIONS

Although H3 K27M mutant–positive HGSG was associated with poor outcomes in adult patients, the outcomes of patients with H3 K27M mutant–positive HGSG were somewhat more favorable compared with those of their H3 K27M mutant–negative HGSG counterparts. Further preclinical animal studies and larger clinical studies are needed to further understand the age-dependent effects of H3 K27M mutation.
Use of an intraoperative sodium oxychlorosene–based infection prevention protocol to safely decrease postoperative wound infections after spine surgery
Authors: Alentado Vincent J. , Berwanger Robert P. , Konesco Anabel M. , Potts Alex J. , Potts Caroline A. , Stockwell David W. , Dbeibo Lana , DePowell John J. , Horn Eric M. , Khairi Saad A. , McCanna Shannon P. , Mobasser Jean-Pierre , Rodgers Richard B. , Potts Eric A.
Published: September 2021

OBJECTIVE

Postoperative infection remains prevalent after spinal surgical procedures. Institutional protocols for infection prevention have improved rates of infection after spine surgery. However, prior studies have focused on only elective surgical patients. The aim of this study was to determine the efficacy of a multiinstitutional intraoperative sodium oxychlorosene–based infection prevention protocol for decreasing rate of infection after instrumented spinal surgery.

METHODS

A retrospective analysis was performed at two tertiary care institutions with level I trauma programs, and patients who underwent posterior instrumented spinal fusion between January 1, 2011, and May 31, 2019, were included. Postoperative deep wound infection rates were captured before and after implementation of a multiinstitutional infection prevention protocol. Possible adverse outcomes related to infection prevention techniques were also examined. In addition, consecutive patients treated from January 1, 2018, to May 31, 2019, were prospectively included in a database to collect preoperative and postoperative spine-specific quality of life measures and to assess the impact of postoperative infection on quality of life.

RESULTS

A total of 5047 patients fit the inclusion criteria. Of these, 1043 patients underwent surgery prior to protocol implementation. The infection rate of this cohort (3.5%) decreased significantly after protocol implementation (1.2%, p < 0.001). Postoperative sterile seroma rates did not differ between the preprotocol and postprotocol groups (0.7% vs 0.7%, p = 0.5). In the 1031 patients who underwent surgery between January 2018 and May 2019, the fusion rate was 89.2%. Quality of life outcomes between patients with infection and those without infection were similar, although statistical power was limited owing to the low rate of infection. Notably, 2 of 10 patients who developed deep wound infection died of infection-related complications.

CONCLUSIONS

An intraoperative sodium oxychlorosene–based infection prevention protocol helped to significantly decrease the rate of infection after spine surgery without negatively impacting other postoperative procedure-related metrics. Postoperative wound infection may be associated with higher-than-expected rate of postoperative mortality.
The novel prognostic value of postoperative follow-up lateral spread response after microvascular decompression for hemifacial spasm
Authors: Cho Minjae , Ji So Young , Go Kyeong-O , Park Kyung Seok , Kim Jong-Min , Jeon Young-Tae , Ryu Jung-Hee , Park Sanghon , Han Jung Ho
Published: September 2021

OBJECTIVE

The lateral spread response (LSR) is an aberrant electrophysiological response in which a stimulus on one branch of the facial nerve spills over to other branches of the nerve, which can be captured by electrodes near each branch. The authors performed this study to evaluate the prognostic value of the follow-up LSR with a sufficient time interval from intraoperative LSR (IO-LSR) after microvascular decompression (MVD) for hemifacial spasm (HFS), excluding the interference of various intraoperative situations.

METHODS

A total of 247 patients treated with MVD for HFS between June 2011 and March 2019 were enrolled in this study. The IO-LSR was routinely evaluated in all patients. The LSR was checked again on postoperative day (POD) 2 after surgery (POD2-LSR). A total of 228 patients (92.3%) were considered cured at the last clinical follow-up.

RESULTS

The IO-LSR disappeared in 189 patients (76.5%), and among them, 181 patients (95.8%) were cured 1 year after surgery. The POD2-LSR disappeared in 193 patients (78.1%), and 185 patients (95.9%) among them were cured. Among the 189 patients in which the IO-LSR disappeared, the POD2-LSR reappeared in 26 patients (13.8%). In contrast, the POD2-LSR disappeared in 30 (51.7%) of 58 patients for whom the IO-LSR continued at the end of surgery. When classified into groups according to the status of the IO-LSR and POD2-LSR, in the group of patients in whom both LSRs disappeared, the cure rate was 98.2%, which was significantly higher than that of the other 3 groups (p < 0.05, Cochran-Armitage trend test). The use of both LSRs was found to be significantly associated with better predictability (p < 0.05, McNemar’s test).

CONCLUSIONS

Postoperative follow-up LSR examination may be beneficial in predicting clinical outcomes after MVD for HFS, especially when considered together with IO-LSR.
Targeting of cyclin-dependent kinases in atypical teratoid rhabdoid tumors with multikinase inhibitor TG02
Authors: Ding Andy S. , Huq Sakibul , Casaos Joshua , Raj Divyaansh , Morales Manuel , Zhao Tianna , Kim Timothy , Srivastava Siddhartha , Pant Ayush , Serra Riccardo , Gorelick Noah L. , Brem Henry , Tyler Betty
Published: September 2021

OBJECTIVE

Atypical teratoid rhabdoid tumors (ATRTs) are aggressive pediatric brain tumors with no current standard of care and an estimated median patient survival of 12 to 18 months. Previous genetic analyses have implicated cyclin D1 and enhancer of zeste homolog 2 (EZH2), a histone methyltransferase that is implicated in many cancers, as key drivers of tumorigenicity in ATRTs. Since the effects of EZH2 and cyclin D1 are facilitated by a host of cyclin-dependent kinases (CDKs), the authors sought to investigate the potential therapeutic effects of targeting CDKs in ATRTs with the multi–CDK inhibitor, TG02.

METHODS

Human ATRT cell lines BT12, BT37, CHLA05, and CHLA06 were selected for investigation. The effects of TG02 on cell viability, proliferation, clonogenicity, and apoptosis were assessed via Cell Counting Kit-8 assays, cell counting, clonogenic assays, and flow cytometry, respectively. Similar methods were used to determine the effects of TG02 combined with radiation therapy (RT) or cisplatin. Synergism indices for TG02-cisplatin combination therapy were calculated using CompuSyn software.

RESULTS

TG02 was observed to significantly impair ATRT cell growth in vitro by limiting cell proliferation and clonogenicity, and by inducing apoptosis. TG02 inhibited ATRT cell proliferation and decreased cell viability in a dose-dependent manner with nanomolar half maximal effective concentration (EC50) values (BT12, 207.0 nM; BT37, 127.8 nM; CHLA05, 29.7 nM; CHLA06, 18.7 nM). TG02 (150 nM) dramatically increased the proportion of apoptotic ATRT cells 72 hours posttreatment (TG02 8.50% vs control 1.52% apoptotic cells in BT12, p < 0.0001; TG02 70.07% vs control 15.36%, p < 0.0001). Combination therapy studies revealed that TG02 acted as a potent radiosensitizer in ATRT cells (BT12 surviving fraction, RT 51.2% vs RT + TG02 21.7%). Finally, CompuSyn analysis demonstrated that TG02 acted synergistically with cisplatin against ATRT cells at virtually all therapeutic doses. These findings were consistent in cell lines that cover all three molecular subgroups of ATRTs.

CONCLUSIONS

The results of this investigation have established that TG02 is an effective therapeutic against ATRTs in vitro. Given the lack of standard therapy for ATRTs, these findings help fill an unmet need and support further study of TG02 as a potential therapeutic option for patients with this deadly disease.
inserção do idoso no mercado de trabalho como instrumento garantidor da dignidade
Authors: Martins Silva Dayane , Tayanne Azarias de Oliveira Jéssica , Silva de Almeida Maikiane , Grossi Vieira Almeida Costa Nathércia , Ferreira de Souza Neto Sebastião , Elaine Carneiro de Moraes Bárbara , Maria dos Reis Fernanda , Dutra Franco Loren , De Fátima Alvarez Saraiva Marize
Published: September 2021

O presente artigo analisa o direito ao trabalho como forma de garantir a dignidade da pessoa humana, estuda a influência do aspecto sociocultural no exercício laboral dos idosos, examina as ações afirmativas propostas pelos governos, bem como o papel da função social da empresa na concretização de direitos trabalhistas desse grupo, além de averiguar de que forma a educação interfere em sua inserção no mercado de trabalho formal. O objetivo geral desta pesquisa é analisar a incorporação dos anciãos no mercado de trabalho, investigando os aspectos sociais, educacionais e governamentais. Para atingir tal escopo, realizou-se um levantamento bibliográfico e documental e uma pesquisa de campo explicativa (TUMELERO, 2020). Os resultados encontrados demonstram que o nível educacional do trabalhador é elemento essencial para a sua colocação de modo menos precário na atividade produtiva. Quanto mais baixo o grau de escolaridade, mais passíveis estarão os idosos de trabalharem de maneira informal.
Responsabilidade civil por danos morais coletivos causados pela veiculação de publicidade enganosa nas plataformas de Marketplace
Authors: GERMANO ALVES FABRICIO , Rodrigo Duarte de Melo Lucas
Published: September 2021

O presente trabalho trata dos danos morais coletivos causados pela veiculação de publicidade enganosa no âmbito do comércio eletrônico. Serão abordadas questões referentes à publicidade enganosa veiculada nas plataformas de marketplace e respectiva responsabilidade civil. Ainda existem muitas dúvidas sobre sua classificação quanto à forma de averiguação da culpa e a determinação sobre quais sujeitos podem ser responsabilizados. A definição da responsabilidade é importante para a proteção do consumidor no comércio eletrônico, no qual sua vulnerabilidade é acentuada. Buscar-se-á verificar se tal responsabilização ocorrerá objetivamente ou subjetivamente, sobre quais sujeitos da relação de consumo ela recairá, se esta será solidária ou subsidiária e ainda quem serão os sujeitos atingidos. A metodologia utilizada consiste em pesquisa aplicada, com abordagem hipotético-dedutiva e qualitativa, com objetivo descritivo. Conclui-se que a responsabilidade civil por publicidade enganosa é objetiva e solidária entre o fornecedor vendedor e a plataforma de marketplace.
Liberdade de imprensa em momentos de crise
Authors: Tito Bianca , Alem Mello Ferreira Rafael
Published: September 2021

Diante da pandemia do novo coronavírus (COVID-19) o mundo se vê inserido em uma nova realidade, na qual diversos profissionais são chamados a assumir a linha de frente no combate a sua propagação. Utilizando do papel assumido pelos meios de comunicação durante esse período, o artigo analisa como a concretização do direito à informação, através do exercício da liberdade de imprensa, pode auxiliar os cidadãos em momentos de crise. O que é feito a partir da metodologia da pesquisa bibliográfica, levantando as principais referências consideradas pertinentes ao tema. Sua realização revela-se oportuna pela relevância e atualidade, contribuindo de maneira positiva com a produção de trabalhos que investiguem questões relacionadas a pandemia. Ao final, resta verificado que, com responsabilidade e unidos em prol da informação, os meios de comunicação exercem um importante papel para a sociedade no combate ao vírus, demonstrando a necessidade de informações verídicas especialmente em momentos de crise mundial.
Eine theoretische Orientierung für die Soziale Arbeit in Zeiten des Klimawandels
Authors: Schmidt Marcel
Published: September 2021

Während Begriffe wie Klimawandel und sozial-ökologische Transformation zum festen Bestandteil der fachlichen wie alltäglichen Kommunikation geworden sind, ist es weder der Disziplin noch der Profession Sozialer Arbeit bislang gelungen, sich fachlich und öffentlichkeitswirksam an dieser Diskussion zu beteiligen. Der Autor geht auf theoretischer Ebene der Frage nach, wie sich daran etwas ändern ließe und womit sich Soziale Arbeit in der Diskussion positionieren könnte.
Die soziale Konstruktion des Kindes und die generationale Ordnung in der Schule
Authors: Zollinger Andreas
Published: September 2021

Vorstellungen von Kindheit und vom Kind sind soziale Konstruktionen und als solche eng mit den Werten und Normen einer Gesellschaft verknüpft, so die Prämisse der sozialwissenschaftlichen Kindheitsforschung. Die Studie untersucht die Prägung dieser Vorstellungen in der Mitte des 19. Jahrhunderts. Analysiert wird der schulische Diskurs zu Kindern und Kindheit in deutschschweizerischen Lehrervereinszeitschriften mittels konstruktivistischer Grounded Theory. Es zeigt sich, dass Kinder durchwegs defizitär konstruiert werden und in der Schule eine strikt asymmetrische generationale Ordnung herrscht. Damit legitimieren Lehrpersonen ihr Ziel, in der Gesellschaft als professioneller Berufsstand anerkannt zu werden.
Financial Capacity and Illiteracy: Does Education Matter in Amnestic Mild Cognitive Impairment?
Authors: Giannouli Vaitsa , Tsolaki Magda
Published: September 2021

Neuropsychological assessment in amnestic mild cognitive impairment (aMCI) becomes complicated when education-literacy is taken into consideration. This study sought to explore the potential influence of literacy/illiteracy and education on financial capacity in patients with multiple-domain aMCI. Six groups consisting of aMCI (illiterate-no formal education, literate with low education, and literate with high education) and non-demented controls were examined. Literacy has an effect on financial capacity, as the illiterate aMCI group alone had the lowest scores in a financial capacity test resembling the performance of patients with mild Alzheimer’s disease. In controls there was a similar pattern, but all three healthy groups regardless of education scored above the cut-off score for incapacity.
Uncertainties in Adoption of Model-Based Definition and Enterprise for High-Value Manufacturing
Authors: Goher Kamran , Shehab Essam , Al-Ashaab Ahmad , Sarfraz Shoaib
Published: September 2021

The world is adopting digital technologies at a rapid pace which are the key enablers to improve every walk of life in the modern era. This quest for digitization has equal rigor within the manufacturing industry. 2D drawings have been used historically to define the specifications of a product for manufacturing. The evolution in digital technologies has made it possible to improve the way of representing these specifications in the form of 3D models which is known as Model-Based Definition (MBD). However, the 2D representation is still the authoritative source within the industry for engineering definition and related documents in the product lifecycle. Though MBD has been adopted in design, discrete part manufacturing, and inspection stages to some extent, the industry heavily relies on the conventional 2D representation of product definition. The digitization process of product definition lies within the adoption of MBD as the authoritative source for all the enterprise activities which is referred to as Model- based Enterprise (MBE). However, there are several uncertainties and risks in this process. In this work, it is ascertained to formulate the key uncertainties in the transformation towards MBD/E. These uncertainties are categorized and analyzed further for visualization.
Men with paraphilic interests and their desire to interact with a sex robot
Authors: Marečková Alena , Androvičová Renáta , Bártová Klára , Krejčová Lucie , Klapilová Kateřina
Published: September 2021

Sex robots may present an opportunity for a clinical management of individuals with paraphilic interests whose realisation would result in infliction of harm and/or legal consequences. We explored the prevalence of desire for sex robot experience in a control group and two target groups: one with paraphilic interests in minors, the other with interest in non-consent/violence. We expected both target groups to express a greater desire for sex robot experience than the control group, because sex robots would enable them to express paraphilic sexuality within legal limitations. We used data from two samples of male respondents. The control sample consisted of respondents from a representative online Czech sample (N = 806). Target groups of individuals with paraphilic interests consisted of 48 subjects sexually interested in minors and 57 subjects sexually interested in non-consent/violence against adults. Sex robot experience was desired by 18% of respondents in the control group, 37.5% of respondents in the group interested in minors, and 26% of respondents interested in non-consent/violence. This indicates that individuals with paraphilic interest in minors are slightly more open to the idea of sex robot experience. Studies exploring preferred features of sex robots and interest in their use in therapy are needed.
Levels of Receptor for Advanced Glycation End Products and Glyoxalase-1 in the Total Circulating Extracellular Vesicles from Mild Cognitive Impairment and Different Stages of Alzheimer’s Disease Patients
Authors: Haddad Mohamed , Perrotte Morgane , Ben Khedher Mohamed Raâfet , Madec Elise , Lepage Aurelie , Fülöp Tamás , Ramassamy Charles
Published: September 2021

Background: Growing evidence supports that receptor for advanced glycation end products (RAGE) and glyoxalase-1 (GLO-1) are implicated in the pathophysiology of Alzheimer’s disease (AD). Extracellular vesicles (EVs) are nanovesicles secreted by almost all cell types, contribute to cellular communication, and are implicated in AD pathology. Recently, EVs are considered as promising tools to identify reliable biomarkers in AD. Objective: The aim of our study was to determine the levels of RAGE and GLO-1 in circulating EVs from mild cognitive impairment (MCI) and AD patients and to analyze their correlation with the clinical Mini-Mental State Examination and Montreal Cognitive Assessment scores. We have studied the possibility that neuronal cells could release and transfer GLO-1 through EVs. Methods: RAGE and GLO-1 levels were measured in circulating EVs, respectively, by Luminex assay and western blot. Released-EVs from SK-N-SH neuronal cells were isolated and GLO-1 levels were determined by western blot. Results: Our data showed higher levels of RAGE in EVs from late AD patients while GLO-1 levels in EVs from early AD were lower as compared to control and MCI patients. Interestingly, levels of RAGE and GLO-1 in EVs were correlated with the cognitive scores regardless of age. For the first time, we demonstrated that GLO-1 was released from neuronal cells through EVs. Conclusion: Although more samples will be needed, our preliminary results support the use of peripheral EVs cargo as new tools for the discovery of peripheral AD biomarkers.
An Integrative Literature Review on the Nomenclature and Definition of Dementia at a Young Age
Authors: van de Veen Dennis ,   The PRECODE Study Group, Bakker Christian , Peetoom Kirsten , Pijnenburg Yolande , Papma Janne M. , de Vugt Marjolein , Koopmans Raymond
Published: September 2021

Background: There has been growing interest in young people living with dementia. Future research requires consensus on the terminology and operational definition of this group. Objective: The purpose of this integrative review was to explore and include all operational definitions used to define dementia at a young age. Methods: On August 14, 2020, the PubMed, Embase, Cinahl, and PsycInfo databases were searched for empirical and theoretical literature using Google. Various terms to describe and define ‘dementia’ and ‘at a young age’ were used to collect literature concerning terminology; age-related aspects, including cut-off ages and criteria; and etiologies of dementia at a young age. Results: The search yielded 6,891 empirical and 4,660 theoretical publications, resulting in the inclusion of 89 publications, including 36 publications containing an explicit discussion and 53 publications as confirmation. ‘Young-onset dementia’ was the most commonly used term of seven identified terms, in the last two decades. The age of 65 years at symptom onset was used most frequently when considering a total of six upper age limits and four criteria to define a cut-off age. Eight lower age limits and an option for subdivision based on age were included. We identified 251 different etiologies and 27 categories of etiologies. Conclusion: Despite relative consensus on the term young-onset dementia and an age at symptom onset being used as a cut-off criterion, much is still unclear concerning possible etiologies of dementia at a young age. In the current study, controversies were detected for discussion in an international consensus study.
Early Microstructure Changes of White Matter Fiber Bundles in Patients with Amnestic Mild Cognitive Impairment Predicts Progression of Mild Cognitive Impairment to Alzheimer’s Disease
Authors: He Fangmei ,   Alzheimer’s Disease Neuroimaging Initiative, Zhang Yuchen , Wu Xiaofeng , Li Youjun , Zhao Jie , Fang Peng , Fan Liming , Li Chenxi , Liu Tian , Wang Jue
Published: September 2021

Background: Amnestic mild cognitive impairment (aMCI) is the transitional stage between normal aging and Alzheimer’s disease (AD). Some aMCI patients will progress into AD eventually, whereas others will not. If the trajectory of aMCI can be predicted, it would enable early diagnosis and early therapy of AD. Objective: To explore the development trajectory of aMCI patients, we used diffusion tensor imaging to analyze the white matter microstructure changes of patients with different trajectories of aMCI. Methods: We included three groups of subjects:1) aMCI patients who convert to AD (MCI-P); 2) aMCI patients who remain in MCI status (MCI-S); 3) normal controls (NC). We analyzed the fractional anisotropy and mean diffusion rate of brain regions, and we adopted logistic binomial regression model to predicate the development trajectory of aMCI. Results: The fraction anisotropy value is significantly reduced, the mean diffusivity value is significantly increased in the two aMCI patient groups, and the MCI-P patients presented greater changes. Significant changes are mainly located in the cingulum, fornix, hippocampus, and uncinate fasciculus. These changed brain regions significantly correlated with the patient’s Mini-Mental State Examination scores. Conclusion: The study predicted the disease trajectory of different types of aMCI patients based on the characteristic values of the above-mentioned brain regions. The prediction accuracy rate can reach 90.2%, and the microstructure characteristics of the right cingulate band and the right hippocampus may have potential clinical application value to predict the disease trajectory.
Reduced Synaptic Transmission and Intrinsic Excitability of a Subtype of Pyramidal Neurons in the Medial Prefrontal Cortex in a Mouse Model of Alzheimer’s Disease
Authors: Zhang Xiao-Qin , Xu Le , Yang Si-Yu , Hu Lin-Bo , Dong Fei-Yuan , Sun Bing-Gui , Shen Hao-Wei
Published: September 2021

Background: Abnormal morphology and function of neurons in the prefrontal cortex (PFC) are associated with cognitive deficits in rodent models of Alzheimer’s disease (AD), particularly in cortical layer-5 pyramidal neurons that integrate inputs from different sources and project outputs to cortical or subcortical structures. Pyramidal neurons in layer-5 of the PFC can be classified as two subtypes depending on the inducibility of prominent hyperpolarization-activated cation currents (h-current). However, the differences in the neurophysiological alterations between these two subtypes in rodent models of AD remain poorly understood. Objective: To investigate the neurophysiological alterations between two subtypes of pyramidal neurons in hAPP-J20 mice, a transgenic model for early onset AD. Methods: The synaptic transmission and intrinsic excitability of pyramidal neurons were investigated using whole-cell patch recordings. The morphological complexity of pyramidal neurons was detected by biocytin labelling and subsequent Sholl analysis. Results: We found reduced synaptic transmission and intrinsic excitability of the prominent h-current (PH) cells but not the non-PH cells in hAPP-J20 mice. Furthermore, the function of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels which mediated h-current was disrupted in the PH cells of hAPP-J20 mice. Sholl analysis revealed that PH cells had less dendritic intersections in hAPP-J20 mice comparing to control mice, implying that a lower morphological complexity might contribute to the reduced neuronal activity. Conclusion: These results suggest that the PH cells in the medial PFC may be more vulnerable to degeneration in hAPP-J20 mice and play a sustainable role in frontal dysfunction in AD.
Dementia Caregivers’ Experiences Engaging Supportive Services While Residing in Under-Resourced Areas
Authors: Cotton Quinton D. , Kind Amy J.H. , Kim Alice J. , Block Laura M. , Thyrian Jochen René , Monsees Jessica , Shah Manish N. , Gilmore-Bykovskyi Andrea
Published: September 2021

Background: Family caregivers of people living with dementia benefit from supportive service use to address care needs associated with caregiving. Yet, research consistently demonstrates low rates of service use. Existing research has focused on barriers and facilitators to service use, with few studies examining the influence of caregivers’ environmental context which often patterns social advantage and health services accessibility. Objective: To describe the perspectives of caregivers residing in socially disadvantaged areas have in regards to utilizing supportive services. Methods: Ten informal caregivers residing in socially disadvantaged areas participated in in-depth interviews that were analyzed using thematic analysis. Results: Across all interviews, caregivers spontaneously described common precedents of service use (crisis or accumulation of unmet needs) and a distinct sequence of stages (seeking, initiating, and utilizing) surrounding service engagement. Major themes characterizing caregivers’ experiences throughout service engagement highlight the varied influence of personal, familial, health, and social system-related factors. Findings demonstrate that caregivers may have different service needs as dementia progresses and that gerontological social work practice can facilitate service use. Conclusion: While preliminary, these findings provide important insights into new domains that can be further examined in future research and intervention efforts to improve supportive service use in socially disadvantaged and underserved communities.
Seasonal Characteristics of Temperature Gradient in a Glaciated Catchment in Eastern Himalaya
Authors: Vashisht Pradeep , Tayal Shresth
Published: September 2021

With climatic information from four stations in Rathong Chu valley for the period from 2017 to 2018, this study presents monthly and seasonal characteristics of the temperature lapse rate (TLR) in the eastern Himalayas. The station heights utilised in the study ranged from 1,742 to 4,450 m. The TLRs were assessed utilising a linear regression model. The mean yearly TLR for eastern Himalaya is less sheer (-0.52°C/100 m) beneath the tree line than (-0.47°C/100 m) over the tree line. The series of TLR exhibits two peaks in a year which confirms the distinctive controlling elements in the individual seasons. The highest TLR was found to be -0.60 °C/100 m during the pre-monsoon season below the tree line and -0.64 °C/100 m above the tree line. The post-monsoon has the second highest lapse rate change beneath the tree line (-0.58 °C/100 m) and in the monsoon (-0.57 °C/100 m) above the tree line. The minimum lapse rates were observed in the winter season below the treeline (-0.42 °C/100 m) and (-0.18 °C/100 m) above the tree line. The outcomes of this study add to the insight of elevation-dependent warming affected by worldwide climate change. Results also suggest that the climate and glacier modelling using the satellite temperature records or by applying the environmental lapse rate on temperature records from low altitudes may not be presenting the actual temperature trends.