bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Penerapan Fitur Aplikasi Si Perlu dalam Meningkatkan Kedisiplinan Kerja Karyawan Puskesmas Kecamatan Yosowilangun Kabupaten Lumajang Perspektif Etos Kerja Islam
Authors: Nasrullah Adam , Fuaddi Muhammad Anwar , Sutrisno Moch , Fitriana Aniqotuzzuhro'
Published: May 2024

The Yosowilangun Health Center in improving employee discipline, implements an attendance system using the Si Need application feature with the aim of making it easier to control, supervise and evaluate the level of employee discipline. The Si Perlu application feature also has deficiencies in its work system, such as this application cannot be used when the lights are off, it is difficult to access employee attendance at the same time, and this application can be accessed if the employee's cellphone has a high capacity because this application has high RAM requirements as well. This study aims to determine the application of the Islamic work ethic to the employees of the district health center. Yosowilangun. This research uses qualitative techniques with descriptive research types. Data collection methods used are observation, literature study, interviews and documentation. The results of this study show that by enforcing absenteeism using the Si Need application feature at the Kec. Yosowilagun, employee discipline at work can be said to be stable and has increased.
Pendekatan Project Based Learning (PJBL) untuk Meningkatkan Keterlibatan Siswa dan Prestasi Belajar pada Mata Pelajaran Sejarah Kelas X di SMA Swasta Kartika 1-4 Pematangsiantar
Authors: Harahap Rika Rahmadhani
Published: May 2024

The research explores the utilization of project-based learning approaches in teaching history to tenth-grade students at Kartika 1-4 Pematangsiantar Private High School. Forty students participated in the study, with the objective of assessing the impact of this approach on academic performance and engagement levels. Various data collection instruments, such as observation sheets, interviews, written exams, field notes, and student worksheets, were employed in this two-cycle classroom action research. Study results suggest that integrating project-based learning models into history learning can positively impact student engagement and academic performance. The increase in students' grades in each cycle corroborates these findings. In cycle I, research success criteria that emphasize students' active participation in physical, mental and social aspects in the learning process are met in 75% of cases. Student learning outcomes are scored 75 on a scale of 1 to 100. When the project-based learning paradigm was implemented, student participation increased significantly, with an average score of 80% and a rise from 67% to 92% between cycles. Furthermore, each learning outcome's average score rose from 72.5% in cycle I to 95% in cycle II, with an 83.8% categorization level. These findings imply that the use of project-based learning approaches can enhance students' academic achievement and encourage ongoing learning.
Sejarah dan Fungsi Masjid Syekh Zainal Abidin di Pudun Julu, Kecamatan Batunadua, Kota Padangsidimpuan
Authors: Rambe Ahmad Zubeir , Ritonga Sakti , Nasution Kasron
Published: May 2024

This research examines the history and development of Syekh Zainal Abidin Mosque in Pudun Julu, Batunadua District, Padangsidimpuan, using a historical methodology approach. Built in 1880 AD, the mosque serves as an exemplar of Islamic architectural art, reflecting the evolution of Islam and the process of Islamization in Padangsidimpuan. The mosque is named after its founder, Syekh Zainal Abidin, also known as Harahap (1811-1901). Initially serving as a center for spiritual activities, political affairs during the colonial era, an educational institution, a place for traditional spiritual practices (parsulukan), and a medical center. However, presently, its function is primarily focused on being a place of worship, without involving religious and social rituals as in the past. This transformation reflects the mosque's adaptation to changing times while preserving its spiritual values. This study provides insights into the dynamic roles of the mosque within the local context.
Dinamika Arsitektur Masjid Jamik Ismailiyah Tanjung Beringin, 1937-1982
Authors: Al Zufri Al Zufri , Asari Hasan , Siregar Yusra Dewi
Published: May 2024

This research aims to describe the architectural dynamics inherited by the Bedagai Kingdom through cultural acculturation, focusing on the Jamik Ismailiyah Mosque. The mosque was founded in 1880 by Prince Ismailiyah and underwent dynamic changes in form while still maintaining its historical existence. This research uses the historical method which includes heuristics, verification, interpretation, and historiography to explore the problem in depth. Observations were made using architectural theory and diachronic theory to provide a complete picture of the architectural dynamics of the Jamik Ismailiyah Mosque in Tanjung Beringin District, Serdang Bedagai. The results showed that since the establishment of the mosque in 1880 until 1982, there were various architectural acculturations that mostly still dominated traditional Malay architectural patterns. This research reveals the dynamics and development of the mosque's architectural concept based on history and acculturation findings, including changes in the layout and additions to the mosque building, providing a complete picture of the dynamic development during the period 1937-1982.
Persepsi Masyarakat Panipahan Terhadap Tuan Syekh Haji Muhammad Sa’id bin Isma’un, 1965-2002
Authors: Sitepu Khairani Akmal , Sumanti Solihah Titin , Batubara Abdul Karim
Published: May 2024

This research examines the Panipahan community's perception of the figure of Tuan Sheikh Haji Muhammad Sa'id Bin Isma'un in Panipahan City, Riau, during the period 1965-2002. The background of this research is the important role of Tuan Sheikh Haji Muhammad Sa'id in the religious and social life of the Panipahan community. The main question asked is how the Panipahan community perceived the contribution and influence of Mr. Sheikh Haji Muhammad Sa'id during this period. The research method used is a descriptive qualitative approach, with data collection techniques through in-depth interviews, observation, and document analysis. The results showed that the Panipahan community had a very positive view of Tuan Sheikh Haji Muhammad Sa'id, recognizing his contribution in religious education, moral development, and social conflict resolution. The conclusion of this study is that Tuan Sheikh Haji Muhammad Sa'id is recognized as an influential and respected figure, who has made a significant impact on social and religious development in Panipahan, Riau. The findings strengthen the argument that religious figures have an important role in shaping social and cultural dynamics in local communities.
Hadis Rasulullah SAW yang Berkaitan dengan Janabah dan Tayamum
Authors: Sukatin Sukatin , Adhiyah Adhiyah , Asshidiqi Hasbi , Masobirin Masobirin , Nurmania Nurmania
Published: May 2024

Islam stands out as the only religion that places a profound emphasis on cleanliness, purity, and health for humanity, particularly among Muslims, through practices like bathing and tayammum ablution. These practices are divinely commanded to ensure that individuals remain healthy, clean, and free from various impurities. The Islamic faith is not only profound but also adorned with blessings and conveniences bestowed by Allah. As an omniscient deity, Allah facilitates ease in worship to prevent His creations from negligence and disobedience. This facilitation, known as kerhoksoan, becomes evident when accessibility to water poses a challenge. In such instances, Allah has provided a practical solution through the ritual of tayammum. Expanding on the significance of tayammum, it serves as a testament to Allah's benevolence, offering flexibility in adherence to religious practices. This divine accommodation ensures that even under challenging circumstances, believers can maintain spiritual and physical well-being.
Menganalisis Kemampuan Berpikir Kritis Peserta Didik pada Pembelajaran Biologi dalam Strategi Problem-Based Learning
Authors: Azla Marisa , Efvita Yuke , Laila Rika Rahma
Published: May 2024

The aim of this research was to analyze students' critical thinking abilities in biology learning process that used a problem-based learning strategy. This research used a quantitative approach, and research design was descriptive. The population consists of class X students at SMA N 2 Mandau. This research was conducted in August 2023. The total sample was 180 respondents. The instrument was questionnaires. The research results showed that an average percentage of 77.4% of respondents answered Yes, the meaning that respondents used their critical thinking skills in the biology learning process based on critical thinking indicators. Biology learning process at SMA N 2 Mandau showed the involvement of critical thinking skills using problem-based learning strategies. It was showed that students' critical thinking abilities was in the high category. Problem-based learning strategy can train the students to be more active in critical thinking.
Efektivitas Penggunaan Model Pembelajaran Cooperative Learning dalam Mata Pelajaran Biologi Terhadap Hasil Belajar Siswa
Authors: Huda Muhammad Komarul
Published: May 2024

This research evaluates the effectiveness of the Cooperative Learning instructional model in enhancing high school students' Biology learning outcomes. Employing an experimental design with pretest-posttest control groups, the study randomly selects two groups of students. Data collection methods include pretests, posttests, classroom observations, and questionnaires to assess interactions and perceptions. Descriptive and inferential statistics analyze significant differences in learning outcomes before and after implementing Cooperative Learning. Findings aim to inform educators, teachers, and stakeholders about the model's efficacy in Biology education. Implications suggest potential improvements in teaching strategies for Biology and other subjects, offering valuable insights for educational practitioners. This research contributes to understanding the Cooperative Learning model's effectiveness in enhancing students' learning outcomes, providing a basis for recommending more effective teaching strategies in various educational contexts.
Peran Intelektual Indonesia dalam Politik pada Periode 1997-1999
Authors: Pakpahan Irwan Luigi Mukhtar , Sumantri Pulung , Nurasiah Nurasiah
Published: May 2024

This research delves into the intricate dynamics of Indonesian intellectuals and the political landscape from 1997 to 1999. Utilizing qualitative research and literature analysis, it unveils the pivotal role intellectuals played in shaping democracy in Indonesia during these tumultuous years. The findings emphasize democracy's imperative nature, evolving from a necessity to a social reality. Intellectuals' engagement from 1997-1999 reflects a collective effort to establish a democratic framework. The social and political dynamics of the 1998 reform era significantly influenced democratic development. Presently, the impact is evident, granting unprecedented freedom of expression, association, and press freedom. The Reform Movement, responding to multifaceted crises, emerged as an unwavering force, enjoying overwhelming public support. This research illuminates the Reform Movement's profound significance in shaping Indonesia's democratic landscape, underscoring its nonnegotiable essence.
Kebijakan DPRK Gayo Lues Tentang Reformasi Birokrasi di Lingkup Pemerintah Gayo Lues: Studi Kasus DPRK Kabupaten Gayo Lues
Authors: Andika Mawan Arris , Junaidi Junaidi , Indra Farhan
Published: May 2024

To realize optimal bureaucratic reform, institutions are needed that have integrity in supervising and supporting government performance, especially in district/city areas, namely the people's representative council. regional (DPRD). The author as a researcher chose qualitative descriptive research to explore the research object. This research shows that the Gayo Lues Regency Government is actively implementing a number of policies to advance the region. The policy focus covers various aspects such as infrastructure development, the policies implemented in Gayo Lues Regency are clearly related to and in line with local laws and regulations. The main goal is to increase the efficiency and transparency of public services. Implementation of reforms includes organizational restructuring, increasing human resource capacity, simplifying administrative processes, and applying information technology. The principles of clean government and good governance are the foundation, with a focus on eradicating corruption and improving the quality of government.
Analisis Peran Perdagangan Maritim Terhadap Sejarah Perekonomian ASEAN
Authors: Darma Aditya , Hutauruk Ahmad Fakhri , Kaban Benny Junior
Published: May 2024

Maritime trade is an economic activity carried out through sea routes such as exports and imports, the main function of maritime trade is to improve the economy of a country and the welfare between entrepreneurs, this maritime trade is not only carried out by two countries but can even be between one country and one organization that has members with several countries in it such as ASEAN. The purpose of this study is to provide knowledge about the role of maritime trade in the history of the economy in ASEAN. The results of this study explain the influence of maritime trade on the economic development of ASEAN and ASEAN member states. ASEAN is an organization formed with the aim of improving the economies of the countries in Southeast Asia consisting of Indonesia, Malaysia, Singapore, Thailand, Vietnam, Brunei Darussalam, Cambodia, Philippines, Myanmar, Laos. This study uses qualitative research with a library study approach to research accurate and relevant data so that readers can easily understand the range of knowledge from this research.
Pengembangan Media Audio Visual Berbasis Film Pendek pada Materi Teks Anekdot pada Kelas X SMK Bina Taruna 2 Medan
Authors: Sarah Ade , Ali Ali , Rita Rita
Published: May 2024

This study aimed to develop and assess the feasibility of short film-based audio-visual learning media for anecdotal text material in class X SMK. The population and sample included 31 students, utilizing the Research and Development (R&D) approach. Following the ADDIE model's five steps—analysis, design, development, implementation, and evaluation—the results indicated the media's validity and suitability for class X SMK students, as determined by media and material experts. Media expert I assessed it as 90% "very appropriate," media expert II as 86% "very eligible," material expert I as 85% "decent," material expert II as 82% "decent," and teacher's assessment as 94% "very feasible." Tested in SMK Bina Taruna 2 Medan, it received 88% "very feasible." In conclusion, the short film-based audio-visual learning media for anecdotal text material is deemed suitable for class X SMK, serving as an effective learning medium.
Pengembangan Bahan Ajar Teks Debat Berbasis Sosial Politik Siswa Kelas X SMA
Authors: Syauqi Muhammad Abrar , Ali Ali , Kartika Rika
Published: May 2024

This study aimed to develop a socio-political-based debate text learning module for class X SMA. Following the 3D model (Define, Design, and Development) proposed by Thiagarajan, the module underwent validation by four experts, including two material experts and two design experts. Utilizing a Likert scale questionnaire, the validation sheet assessed material and design aspects. The material's quality received an average score of 3.60 from the first material expert, deemed "valid and good," and 3.55 from the second material expert, also "valid and good." Design assessment yielded an average of 4.44 from the first expert and 4.25 from the second expert, both indicating "valid and very good." Based on these evaluations, the socio-political debate text learning module is deemed feasible for use, meeting the criteria of validity and quality in both material and design aspects.
Pengembangan Bahan Ajar dengan Media Pembelajaran Scrapbook Materi Teks Biografi pada Siswa Kelas X SMA Istiqlal Deli Tua
Authors: Suhailah Afifah , Rita Rita , Safina Nila , Syahputra Ridwan
Published: May 2024

This study aimed to depict the development, validation, and feasibility of employing Scrapbook learning media for biographical text material in class X SIVIA at SMA Istiqlal, Deli Tua. Utilizing the Research and Development (R&D) approach following the Borg and Gall model, including needs analysis, media development planning, validation, design improvement, product testing, and product revision, involving 150 students. Purposive sampling was employed, with 26 students selected. Both qualitative and quantitative data were collected. The outcome is a Scrapbook-based teaching material. Material expert validation I resulted in a "Good" categorization at 79%, while Material expert validation II reached 82%, indicating a "Good" rating. Design expert I yielded an 80% rating, also "Good," while Design expert II achieved a "Very Good" score at 86%. Teacher responses rated at 82% were deemed "Good," and student responses, totaling 87%, were "Very Good." Trial results from 26 students demonstrated improved learning outcomes using Scrapbook teaching materials.
Pengembangan Media Pembelajaran Wordwall dalam Teks Cerpen Siswa Kelas XI MAS Proyek Univa Medan
Authors: Rosmaini Rosmaini , Ali Ali , Safina Nila
Published: May 2024

This study aims to describe the development process and feasibility of Wordwall learning media in short story texts for XI grade students at MAS Project Univa Medan. The population comprised students from XI MIPA 1, XI MIPA 2, XI IIS, and XI IIA, totaling 100 students, with a sample of 31 students from class XI IIS. Data were collected through questionnaires, observation, interviews, documentation, and questionnaires to explore learning website-based short story material on Wordwall media. Following the Research and Development (R&D) model by Borg and Gall, the study progressed through stages including information gathering, product development, validation test, product revision, and product trial. Results show that Wordwall learning media for short story texts in XI MAS Project Univa Medan are highly feasible. Material experts rated it "Decent" (80%) and "Very Decent" (86%), while media experts rated it "Very Decent" (94%) and (93%), and teachers rated it "Very Decent" (91%). Field implementation tests with 31 students yielded a "Very Feasible" rating (90%). Evaluation tests indicated Wordwall's effectiveness in short story texts, with a "Very Effective" rating (90%).
Penerapan Model Pembelajaran Group Investigation dalam Meningkatkan Hasil Belajar Biologi pada Siswa Kelas XI MIA di SMA Negeri 3 Pematangsiantar
Authors: Huda Muhammad Komarul
Published: May 2024

This study assesses the impact of implementing the Group Investigation (GI) Learning Model on the Biology learning outcomes of grade XI MIA students at SMA Negeri 3 Pematangsiantar. Employing a quasi-experimental design, two experimental groups applied the GI Learning Model, while the control group received conventional teaching. Results revealed a significant enhancement in Biology learning outcomes for the experimental groups, as reflected in improved pre-test and post-test scores. Conversely, the control group exhibited no noteworthy changes. Student responses conveyed a high level of satisfaction with the GI Learning Model in the context of Biology education. These findings recommend educators and policymakers consider GI Learning Model implementation as an effective alternative for enhancing Biology learning outcomes in high schools. Further research is necessary to explore factors influencing the success of this model, along with its implications for curriculum development and teaching methods.
Pengembangan e-LKPD Berbasis Realistic Mathematics Education (RME) Berbantuan Google Form untuk Meningkatkan Kemampuan Berpikir Kritis Siswa Kelas IV SD
Authors: Asni Ade Saswita , Hidayat Wahyu
Published: May 2024

The Covid-19 pandemic forced a swift shift to online learning, prompting the creation of innovative tools like e-Worksheets. This study introduces e-LKPD, a product grounded in Realistic Mathematics Education (RME) and facilitated through Google Forms, designed to enhance critical thinking skills in fourth-grade students. Utilizing the Research and Development (R&D) method with the ADDIE model, the product underwent rigorous evaluation. Results revealed high validity percentages (92.05% for media, 84.67% for material, 94.28% for language) and practicality (93% teacher response, 84.67% student response). Importantly, the e-LKPD demonstrated effectiveness in improving critical thinking skills, establishing itself as a crucial resource for sustaining educational quality amid the challenges posed by the pandemic, ensuring continued progress in the realm of online education. The development of this e-LKPD aligns with the evolving landscape of education, providing a valuable tool to foster critical thinking skills in the digital era.
Penerapan Model Pembelajaran Problem Based Learning (PBL) untuk Meningkatkan dan Hasil Belajar Siswa pada Materi Sistem Pencernaan Manusia di Kelas XI IPA 2 SMAN 1 Bandar Petalangan
Authors: Nadra Syarifah
Published: May 2024

This study aimed to enhance students' interest and learning outcomes in this subject using discussion method and Problem Blended Learning (PBL) model. The research, conducted to determine the most effective teaching method, employed Classroom Action Research with two cycles, including pre-cycle actions. Each cycle consisted of four stages: 1) planning, 2) implementation, 3) observation, and 4) reflection. Results revealed an improvement in learning motivation, as seen in students' active participation during question-and-answer sessions. In the 2020/2021 academic year, the first cycle showed 32.14% of students actively engaged, increasing to 60.71% in the second cycle. Regarding the on-time assignment submission indicator, participation rose from 71.42% in the first cycle to 96.42% in the second cycle. Additionally, the percentage of students scoring above the minimum passing grade increased from 46.43% in the first cycle to 71.42% in the second cycle.
Penerapan Metode Pembelajaran Jigsaw Berbantuan Video Interaktif untuk Meningkatkan Hasil Belajar Siswa Kelas XI di SMAN 1 Kerinci Kanan
Authors: Ardilah Ardilah , Rahayu Indah Ayu Puji , Ertiana Ira , Aisah Siti
Published: May 2024

This research aimed to investigate the effectiveness of the jigsaw learning method assisted by interactive videos in enhancing the learning outcomes of class XI-IPA students at SMAN 1 Kerinci Kanan, specifically focusing on the human digestive system subject. Utilizing a single-cycle PTK (classroom action research) involving planning, implementation, and reflection stages within two meetings, the study engaged 16 students, comprising 7 females and 9 males. Data collection involved interactive learning activities, group discussions, presentations, and reflections on completed Student Worksheets (LKPD). The outcomes revealed a notable improvement in students' learning achievements, indicating the success of the jigsaw method assisted by video learning media in augmenting the knowledge of the students through collaborative activities, presentations, and discussions. The findings underscore the potential of integrating interactive videos with the jigsaw method as an effective approach for enhancing comprehension and engagement in learning the human digestive system among high school students.
Penerapan Metode Inkuiri dengan Teknik Copy the Master dalam Pembelajaran Menulis Cerpen di Kelas XII SMKN Terpadu Provinsi Riau
Authors: Fitri Meliya , Liberti Liberti , Vivinovarina Vivinovarina , Yuliana Yuliana
Published: May 2024

This research investigates the effectiveness of the inquiry learning method employing the "copy the master" technique in enhancing short story writing skills among class XII students at the Agricultural Vocational School. The study employs action research methodology and involves class XII ATP-1, comprising 36 students. Findings reveal that the inquiry method, utilizing the "copy the master" technique, significantly improves short story writing abilities. Results from cycle I and II show an increase from an average score of 77.89 to 81.89, indicating a 4% improvement. The inquiry learning process involves steps such as reading the model writing, analyzing its content and form, creating a writing framework based on the model, and practicing writing by emulating the framework, ideas, or writing techniques from the model. This approach demonstrates promising potential for enhancing students' writing proficiency, offering valuable insights for educators seeking effective strategies to foster writing skills in vocational education settings.
Peningkatan Aktivitas dan Hasil Belajar Materi Tari Pendek Bertema Melalui Metode Field Trip pada Siswa Kelas II SD Negeri 010 Sei Simpang Dua
Authors: Kusrini Sri
Published: May 2024

This study aimed to improve teacher performance, student engagement, and learning outcomes in Thematic Short Dance for third-grade students at SD 010 Sei Simpang Dua. Twenty-six students from SD Negeri Kalibatur in the academic year 2021/2022 participated in the two-cycle research, involving planning, implementation, observation, and reflection. In that academic year, students' learning outcomes were hindered by a teacher-centered approach, limiting their creativity and engagement. To address this, the teacher implemented a field trip method in Thematic Short Dance. Results showed improvement from cycle I to cycle II. Average student learning outcomes increased from 75.40 to 80.65, with mastery rising from 69.23% to 88.46%. Student activity during learning also improved from 71.93% to 78.77%. Teacher performance rose from 80.42 (B) to 88.72 (A). The field trip method effectively enhanced teacher performance, student engagement, and learning outcomes. This research contributes to teaching methods in Arts and Skills (Seni Budaya dan Keterampilan - SBK) at the elementary school level.
Peningkatan Kemampuan Menulis Teks Berita dengan Menggunakan Model Pembelajaran Project Based Learning pada Siswa Kelas VII SMP Negeri 3 Talang Muandau
Authors: Pardede Maniar
Published: May 2024

Implementing the Project Based Learning (PBL) model has shown significant improvement in the ability to write news texts for seventh-grade students at SMP Negeri 3 Talang Muandau. This class action research utilized observation and instrument-based tests, including audiovisual presentations of national news videos and written post-test sheets, to collect data. Analysis involved individual and group scores, average student scores, and criteria-based assessment of student comprehension levels. Results revealed that in the first cycle, only 42% of students met the minimum completion criteria, with an average score of 55, while in the second cycle, all students met the criteria, achieving a 100% average score. Consequently, it can be inferred that the implementation of the PjBL model has significantly enhanced learning outcomes in news text writing for seventh-grade students at SMP Negeri 3 Talang Muandau.
Report on viral infections in ART
Authors: Anastasi Attilio , Capodanno Francesco , Parmegiani Lodovico
Published: May 2024

Human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) are widespread infectious agents. In developed countries, effective therapies have turned potentially lethal HCV, HBV and HIV infections into chronic diseases with a good quality of life, also in terms of reproductive chances. Serodiscordant status is the condition in which only one partner is HIV, HBV and/or HCV positive. In fertile serodiscordant couples, natural conception should be encouraged following specific prophylactic strategies, while infertile serodiscordant couples should be referred for treatment performed using assisted reproduction technology (ART). ART centers working with serodiscordant couples must set up an internal management and control system to guarantee the safety of operators, uninfected patients, gametes and embryos, and also of the fetus, especially during the cryopreservation step. Herein we summarize general features of HIV, HBV and HCV infection, their possible impact on human reproduction, and laboratory recommendations to achieve safe management of serodiscordant couples seeking pregnancy through ART. KEY WORDS: Viral infections, HBV, HCV, HIV, contamination.
Cross-contamination risk management in biobanking. Lesson from the pandemic
Authors: Parmegiani Lodovico , Sosa Fernandez Laura
Published: May 2024

Millions of human gametes are stored worldwide. Cryostorage presents many potential risks to the cryopreserved cells/tissues, including loss of viability and most of all contamination. Assisted reproductive technology (ART) clinics need to develop effective strategies to manage these risks. Human ART is the only medical discipline where human gametes and embryos with the potential to produce live births are routinely stored in liquid nitrogen or nitrogen vapor (LN2/NV). The risk of infection is real, especially when new, highly infectious agents arise. Airborne contaminants come into contact with LN2/NV and are cryopreserved. While some industrial sectors (drug manufacturing, food and beverage sterile packaging) carry out raw filtration of LN2 before use, this precaution is not yet mainstream, although it is increasingly used in the field of human ART. During the COVID-19 pandemic, manufacturers of drugs/disposables/culture media tried to mitigate contamination risk by sourcing raw materials from low-risk regions, but this approach is not feasible in the case of LN2/NV, which can thus become potential vectors of contamination. The risks associated with the use of contaminated LN2/NV are virus awakening and contamination of thawing cells, the environment, and operators. KEY WORDS: Cryopreservation, cryostorage, sterile liquid nitrogen, risk management, contamination, personalized virus-free vitrification.
Two Interviews with Jim Jarmusch
Authors: Peary Gerald
Published: May 2024

Two interviews with the American independent filmmaker, Jim Jarmusch, make up this chapter. In the first, he discusses his concert film, Year of the Horse, which is a recording of the live concert music of Neil Young and his legendary musicians, Crazy Horse. Jarmusch hopes his documentary provides “a little insight into the greatest garage band in the world.” His second interview concerns Ghost Dog: the Way of the Samurai, a modern-age gangster film about a Zen-obsessed assassin played by Forest Whitaker. His film is an homage to American-style crime films made by Japanese and French filmmakers. Jarmusch describes his protagonist as “Don Quixote as a fool" for his samurai-like killings motivated by “seemingly outmoded chivalric rules.”
A Woman of Two Worlds
Authors: Hunter Avalyn
Published: May 2024

This chapter discusses the background and heritage of Rosa Hoots. It looks at her parents, Augustus Captain and Jane Moore, and the impact of the Civil War and federal policies on their lives. It continues through Rosa's marriage to Al Hoots and the personal losses that she and her husband suffered and concludes with the effect of the oil boom on Rosa Hoots's life and her management of Useeit.
Summer of Futility
Authors: Hunter Avalyn
Published: May 2024

The chapter follows Black Gold to the Latonia race meeting, where he encountered the colt who would be his primary nemesis for the rest of the year: Wise Counsellor. It explores Wise Counsellor's unlikely origins and his emergence as a top racehorse that was clearly Black Gold's superior at this point in both colts' development. It continues the theme of Worthmore as Black Gold's secondary antagonist and concludes with the injury that sidelined Black Gold for the remainder of the summer racing season.
Advancing Breast Cancer Subtype Prediction and Mutation Analysis: Integrating Deep Learning and Machine Learning Techniques in Genomic Research
Authors: Gadamsetty Samhita , Angayarkanni Pitchumani
Published: May 2024

Breast cancer, a heterogeneous disease, can be classified into several subtypes, each associated with distinct genetic mutations and clinical outcomes. As per the research article by National Institutes of Health it was stated that 25% of hereditary cases are due to the mutation of highly penetrant genes which leads to 80% lifetime risk of breast cancer [15]. This study aims to apply advanced deep learning and machine learning algorithms to predict breast cancer subtypes and to identify key genetic mutations contributing to the disease using a comprehensive gene expression dataset. We analyzed a dataset comprising 1904 samples, encompassing 331 genes and 175 gene mutations, sourced from a public platform and including PAM50 and Claudin low categorizations. Due to limited observations, SMOTE was employed for data augmentation, and Principal Component Analysis (PCA) was used to assess data variance. Several machine learning models, including Random Forest Classifier, Support Vector Machine, K-Nearest Neighbor, XGBoost, and Stacked models, were applied alongside deep learning techniques like Convolutional Neural Network and Multi-Layer Perceptron. The Stacked model demonstrated superior performance with an accuracy of 0.955, outperforming other models. The deep learning models achieved accuracies of 0.911 (CNN) and 0.936 (MLP). KNN analysis revealed potential clusters based on gene and mutation data, with the silhouette metric identifying "siah1_mut," "nras_mut," and "hras_mut" as significant mutations. The optimal clustering achieved a silhouette score of 0.997 for two clusters. These mutations may play pivotal roles in breast cancer pathogenesis and could serve as targets for therapeutic interventions. Our findings demonstrate the effectiveness of integrating stacked algorithms and deep learning models in predicting breast cancer subtypes. The identification of key mutations through clustering techniques provides valuable insights into the genetic underpinnings of breast cancer, which could guide future research and the development of targeted therapies. This study highlights the potential of advanced computational approaches in elucidating the complex landscape of breast cancer genomics and paves the way for personalized medicine in oncology.
Empirical Evaluation of Deep Learning Architectures in the Early Detection of Alzheimer s Disease through MRI Data Analysis
Authors: Kumari Rashmi , Kohli Anvi , Sunil Arya , Dadhich Arushi , Das Subhranil , Singh Raghwendra Kishore
Published: May 2024

Alzheimer's disease (AD) poses a significant challenge to healthcare systems worldwide, necessitating early detection and intervention for effective management. In this paper, various Deep Learning (DL) architectures such as CNN, Residual Neural Networks (ResNet), and U-Net with Gating (UGNet), and VGG16 for detecting AD at an early stage by applying MRI data which is acquired from the Open Access Series of Imaging Studies (OASIS) dataset. In this method, MRI data is firstly preprocessed for extracting the relevant features which are used for training these models. Paramters of the evaluation metrics such as Classification accuracy, precision, specificity, and area under the receiver operating characteristic curve (AUC-ROC) are applied for assessing the performance of four DL models while AD patients. From the simulation results, it has been observed that high classification accuracy and AUC-ROC scores has been achieved in VGG16 as compared with other models. However, ResNet performs better when it comes on classifying complex image tasks in detecting AD. When convolutional and deconvolutional pathways with gating mechanisms are considered, UG-Net performs a notable performance in comparing to CNN and ResNet. These findings have supported the potentiality of DL techniques in detecting early diagnosis and intervention strategies while contributing to much-improved patient care.
Web Service-Oriented E-learning: Proposition of Semantic Approach to Discover Web Services Related to the E-learning System
Authors: Halim Mohamed , Tahiri Abdelmajid , Ghzizal Yassir El , Adadi Nouha , Chenouni Driss
Published: May 2024

Service Oriented Computing (SOC) is a new paradigm for the flexible, scalable, and cost-effective development of distributed web applications and software. SOCs are widely used for their combination of existing web services, to efficiently create value-added applications. This paradigm, which has proven its efficiency in many fields and various information systems such as e-commerce, is considered to be very beneficial in the field of e-learning. This approach introduces the concept of discovery and invocation of web services published in service directories. Indeed, this document offers an infrastructure to discover web services related to the field of education. This proposition is based on the use of the e-learning domain ontology, the semantic descriptions of web services by OWL-S Language (Web Ontology Language for Web Services) as well as a matching algorithm, to find the adequate services that best meet the requests of users of the e-learning system.
Classification of Heart Disorders Using an Artificial Neural Network Approach
Authors: ti Sumiati , Hendriyati Penny , Triayudi Agung , Yusta Afrasim , Syaefudin Achmad
Published: May 2024

The influence of fast food is very large on people's health, it can cause dangers such as weight gain and obesity, poor nutrition, digestive disorders, increased blood pressure and cholesterol, increased risk of serious diseases such as cancer, diabetes and heart disease. Doctors who diagnose heart disease cannot be seen directly, with the help of an electrocardiogram, an examination using an electrocardiogram to detect abnormalities in the heart such as heart rhythm disturbances and pericarditis. The electrocardiogram tool detects how long the electrical waves last through measuring intervals and the amount of electrical activity in the heart muscle. The electrocardiogram tool consists of 12 leads. This research aims to diagnose heart abnormalities using the backpropagation method approach and to determine the level of accuracy of diagnosing heart abnormalities in patients. An artificial neural network is a network of interconnected nodes, where each connection has a connection weight distributed across all nodes. Meanwhile, the backpropagation learning algorithm is a guided learning algorithm whose input and output are known in advance. In addition to building artificial neural network models for predictive capabilities. Backpropagation is a method of working backwards, which can reduce the number of errors. The model will be evaluated using 10% separate data as validation data. The evaluation model created uses RMSE, confusion matrix, and ROV curve to find out how well the model performs in making predictions. The results of this research show an RMSE (Root Mean Square Error) value of 0.33, a matrix confusion value of 88.89%, and an ROC curve value with an ROC curve area = 0.88. The results of data analysis using artificial neural networks with the backpropagation method approach provide maximum results. The results of data analysis using artificial neural networks with a backpropagation method approach provide maximum results for diagnosing patient heart abnormalities.
Variational Autoencoder Diffusion Model (VAEDM) and Divergence Asynchronous Reinforcement Learning (DARL) for Rail Surface Defect Detection
Authors: Sekaran Samyuktha Sasi , Subaji Dr.M.
Published: May 2024

The speed and load capacity of trains are improving at an accelerating rate, which raises the standards for railway services' security criteria. The track's surface may progressively reveal varying degrees of defects because of the impacts of moisture, temperature, load, and other factors; if the flaws never addressed in a prompt period, the degree of defects would expand, significantly raising the probability of train service. The development of automatic RSDD (Rail Surface Defect Detection) has substantial practical and scientific implications. In this study, a multi-crack detection technique depends on Variational Autoencoder Diffusion Model (VAEDM), The introduction of VAEDM allows for the non-destructive detection of fastener and RSD. In order to produce hidden elements from images that have various cracks, VAEDM combines the multi-layer and a rail surface image encoder was introduced. Zero Shot- Divergence Asynchronous Reinforcement Learning (ZS-DARL), Policy-Gradient is used to establish the relationship between defects and non-defects. DARL transformer encoder is introduced for taking long-range dependences for FE (Feature Extraction) from detected objects images with various patterns and dimensions. The simulation outcomes on the open Railway Track Fault Detection (RTFD) and Rail Surface Defect Datasets (RSDDs) with rail surface defects are collected from rail tracks surface defect detection. Results are measured using the metrics like recall, precision, F-measure, and accuracy.
Leukoaraiosis: Epidemiology, Imaging, Risk Factors, and Management of Age-Related Cerebral White Matter Hyperintensities
Authors: Huang Wen-Qing , Lin Qing , Tzeng Chi-Meng
Published: May 2024

Leukoaraiosis (LA) manifests as cerebral white matter hyperintensities on T2-weighted magnetic resonance imaging scans and corresponds to white matter lesions or abnormalities in brain tissue. Clinically, it is generally detected in the early 40s and is highly prevalent globally in individuals aged >60 years. From the imaging perspective, LA can present as several heterogeneous forms, including punctate and patchy lesions in deep or subcortical white matter; lesions with periventricular caps, a pencil-thin lining, and smooth halo; as well as irregular lesions, which are not always benign. Given its potential of having deleterious effects on normal brain function and the resulting increase in public health burden, considerable effort has been focused on investigating the associations between various risk factors and LA risk, and developing its associated clinical interventions. However, study results have been inconsistent, most likely due to potential differences in study designs, neuroimaging methods, and sample sizes as well as the inherent neuroimaging heterogeneity and multi-factorial nature of LA. In this article, we provided an overview of LA and summarized the current knowledge regarding its epidemiology, neuroimaging classification, pathological characteristics, risk factors, and potential intervention strategies.
A Multimodal Ensemble Deep Learning Model for Functional Outcome Prognosis of Stroke Patients
Authors: Jung Hye-Soo , Lee Eun-Jae , Chang Dae-Il , Cho Han Jin , Lee Jun , Cha Jae-Kwan , Park Man-Seok , Yu Kyung Ho , Jung Jin-Man , Ahn Seong Hwan , Kim Dong-Eog , Lee Ju Hun , Hong Keun-Sik , Sohn Sung-Il , Park Kyung-Pil , Kwon Sun U. , Kim Jong S. , Chang Jun Young , Kim Bum Joon , Kang Dong-Wha ,   KOSNI Investigators
Published: May 2024

Background and Purpose The accurate prediction of functional outcomes in patients with acute ischemic stroke (AIS) is crucial for informed clinical decision-making and optimal resource utilization. As such, this study aimed to construct an ensemble deep learning model that integrates multimodal imaging and clinical data to predict the 90-day functional outcomes after AIS.Methods We used data from the Korean Stroke Neuroimaging Initiative database, a prospective multicenter stroke registry to construct an ensemble model integrated individual 3D convolutional neural networks for diffusion-weighted imaging and fluid-attenuated inversion recovery (FLAIR), along with a deep neural network for clinical data, to predict 90-day functional independence after AIS using a modified Rankin Scale (mRS) of 3–6. To evaluate the performance of the ensemble model, we compared the area under the curve (AUC) of the proposed method with that of individual models trained on each modality to identify patients with AIS with an mRS score of 3–6.Results Of the 2,606 patients with AIS, 993 (38.1%) achieved an mRS score of 3–6 at 90 days post-stroke. Our model achieved AUC values of 0.830 (standard cross-validation [CV]) and 0.779 (time-based CV), which significantly outperformed the other models relying on single modalities: b-value of 1,000 s/mm2 (P<0.001), apparent diffusion coefficient map (P<0.001), FLAIR (P<0.001), and clinical data (P=0.004).Conclusion The integration of multimodal imaging and clinical data resulted in superior prediction of the 90-day functional outcomes in AIS patients compared to the use of a single data modality.
The Influence of Non-High-Density Lipoprotein Cholesterol on the Efficacy of Genotype-Guided Dual Antiplatelet Therapy in Preventing Stroke Recurrence
Authors: Xu Qin , Meng Xia , Li Hao , Xie Xuewei , Jing Jing , Lin Jinxi , Jiang Yong , Wang Yilong , Zhao Xingquan , Li Zixiao , Liu Liping , Wang Anxin , Wang Yongjun
Published: May 2024

Background and Purpose Non-high-density lipoprotein cholesterol (non-HDL-C), which represents the total cholesterol content of all pro-atherogenic lipoproteins, has recently been included as a new target for lipid-lowering therapy in high-risk atherosclerotic patients in multiple guidelines. Herein, we aimed to explore the relationship between non-HDL-C level and the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin in preventing stroke recurrence.Methods This study comprised a post hoc analysis of the CHANCE-2 (Ticagrelor or Clopidogrel in High-Risk Patients with Acute Nondisabling Cerebrovascular Events II) trial, from which 5,901 patients with complete data on non-HDL-C were included and categorized by median non-HDL-C levels, using a cutoff of 3.5 mmol/L. The primary efficacy and safety outcomes were recurrent stroke and severe or moderate bleeding within 90 days.Results Ticagrelor-aspirin significantly reduced the risk of recurrent stroke in patients with low non-HDL-C (71 [4.8%] vs. 119 [7.7%]; adjusted hazard ratio [HR] 0.54; 95% confidence interval [CI], 0.40–0.74), but not in those with high non-HDL-C (107 [7.3%] vs. 108 [7.6%]; adjusted HR, 0.88; 95% CI, 0.67–1.16), compared with clopidogrel-aspirin (P for interaction=0.010). When analyzed as a continuous variable, the benefit of ticagrelor-aspirin for recurrent stroke decreased as non-HDL-C levels increased. No significant differences in the treatment assignments across the non-HDL-C groups were observed in terms of the rate of severe or moderate bleeding (5 [0.3%] vs. 8 [0.5%] in the low non-HDL-C group; 4 [0.3%] vs. 2 [0.1%] in the high non-HDL-C group; P for interaction=0.425).Conclusion CHANCE-2 participants with low non-HDL-C levels received more clinical benefit from ticagrelor-aspirin versus clopidogrel-aspirin compared to those with high non-HDL-C, following minor ischemic stroke or transient ischemic attack.
Membangun dan Mengimplementasikan Budaya Inovatif di Organisasi Modern: Analisis Strategi dan Praktik Terbaik untuk Meningkatkan Daya Saing Organisasi Publik
Authors: Putri Bella Kharisma , Frinaldi Aldri
Published: May 2024

The aim of writing this article is to look at corruption in the form of abuse of official authority in Indonesia. This article applies a qualitative method by applying a descriptive analysis system in presenting it. The data collection technique for this research is a library research library study sourced from various reading literature and previous research articles regarding corruption, a form of abuse of official authority in Indonesia. The rise in public officials caught in corruption cases is no longer a surprising phenomenon. Apart from allegations of self-enrichment, receiving gratuities and bribes, the status of corruption suspects is also given to those who, because of their policies, are suspected of causing state losses.