bluuebunny/crossref_metadata_2025 huggingface dataset:
Gender Violence among UAGro's High School Students
Authors: Cortés-Dillanes Yolanda Emperatriz , Guevara-Rojo Mónica , Antúnez-Nájera Guadalupe
Published: September 2022

This study asked: What is the dimension of gender-based violence among female students at the middle school level at the Autonomous University of Guerrero in Acapulco? The general objective was: to know the indexes of gender violence in the students and the resources that are applied to prevent, attend and eradicate it. It is a quantitative research, a survey was designed and applied to 284 female students. The results provide data indicating situations of gender violence that occur in these spaces, the students experience harassment and/or sexual harassment, it is essential that the institution addresses this situation in a structural way.
PM Summit – Sponsor
Authors: Vázquez Adrián , Salazar Karina , Mendiola María
Published: September 2022

Project management has gradually become an indispensable element for organizations, which need to make their investments more and more profitable. Within organizations, aware of the implications of poor project management and administration, there is a need to create new areas within their organizational structure with the sole purpose of controlling projects from the moment they are formulated, during their execution and until their completion. Nowadays it is very important in the execution and progression of each project to have a suitable Sponsor, the one who will be aware of what you do and in turn giving approval, with the support to approve the activities that a Project Manager will carry out in a job.
Red of Academic Corps in Educational Research of the UAEM
Authors: Carreto-Bernal Fernando , Rojas-Rodríguez María Teresa
Published: September 2022

The network of Academic research bodies UAEM educational, dwells four thematic networks REDIES, social and natural sciences, health sciences, information technology and top-level researchers average 100 teachers and 22 Academic bodies. In December 2013, if the First Meeting of Educational Research Academic Bodies of the Faculty of Geography at the UAEM, at the initiative of CA geography education and training UAEM-CA-144, whence if ACHIEVEMENT integrate CA 15 10 institutions and 20 participants, where the work accomplishment know if that is before Realizing by CA oriented educational research emerging as major initiative the need to work in RED and established the basis for the organization and register Thematic networks based on collegial work inter with the Secretariat of Research and Advanced Studies of UAEM. One of the challenges was to incorporate the NMS With the aim Supporting teachers on recognition on the stage of research in the UAEM.
Articulation of the substantive functions in the Intercultural University of the State of Tabasco
Authors: Morales Guadalupe , Arcos Nicolás , Carrillo Jaime , Reyes Emma
Published: September 2022

Intercultural University of the State of Tabasco incorporates the main functions such as teaching, research and outreach. The purpose of the current work was to know the state about the coordination among these functions. The research was carried out through collective and individual interviews to different actors and considering the analysis of documents previously selected. The results show that the outreach and teaching have a bigger grade of coordination since students and teachers consider that the relation among different academic and community actors has allowed taking advantage of the activities for learning and the development of the communities. The coordination between teaching and research is not clear in the actions that are carried out. In the case of outreach and research it was identified that it is necessary to carry out actions that allow improving the interrelation of these functions since no many activities have allowed reaching a relation between these functions. The coordination of the three main functions is almost non-existent and in the cases that it is identified, the activities were not planned with that purpose.
Pengaruh Metode Latihan Bagian Terhadap Keterampilan Berenang Gaya Bebas
Authors: Rudiana Raden Dadan Pra , Prasetiyo Arif Fajar , Koswara Lala
Published: September 2022

Tujuan dari penelitian ini adalah Untuk mengetahui pengaruh metode latihan bagian terhadap keterampilan renang gaya bebas, serta publikasi di jurnal biormatika. Menggunakan teknik total sampel dengan jumlah 20 sampel, metode penelitian menggunakan eksperimen One-Group Pretest-Posttest Design. Dengan hasil penelitian adalah sebagai berikut terdapat pengaruh metode latihan bagian terhadap keterampilan renang gaya bebas,
Systematic Literature Review : Efektivitas Penggunaan Media Evaluasi Digital dalam Pembelajaran Matematika
Authors: Azzahro Tifani Arum , Subekti Fitrianto Eko
Published: September 2022

Suatu proses pembelajaran yang menjenuhkan dikarenakan kurangnya media dan fasilitas pembelajaran serta cara mengajar yang terlalu monoton akan mempengaruhi tingkat berpikir serta hasil belajar siswa. Beagian dalam proses tersebut adalah evaluasi yang digunakan sebagai tolak ukur guru dalam memberikan nilai maupun predikat ketuntasan bagi siswa. Pengembangan evaluasi tentunya berperan penting dan harus diinovasikan bersamaan dengan pengembangan – pengembangan faktor lainnya. Salah satunya yaitu dengan perkembangan teknologi infromasi dan komunikasi di era digital yang sedang mengalami kemajuan pesat. Akan bagus jika dimanfaatkan dalam bidang pendidikan. Ketika proses pembelajaran dinilai sudah menemukan cara yang efektif, bisa diterima, dan membuat peserta didik antusias, maka dalam penugasan yang kemudian akan diberikan harus mampu membuat siswa lebih tertarik. Hal tersebut bisa dilakukan dengan menerapkan teknologi sebagai bahan media evaluasi pembelajaran yang baru. Peneliti melakukan penelitian dengan metode Systematic Literature Review, yang bertujuan untuk mengidentifikasi efektivitas media evaluasi pembelajaran digital dalam berbagai jurnal – jurnal penelitian yang bertema evaluasi pembelajaran dalam sekolah. Sebanyak 25 literatur dari berbagai database kemudian diinterpretasi dan menghasilkan review tentang penggunaan dan efektivitas bagi siswa dan guru dari sebuah media evaluasi digital dalam pembelajaran matematika yang berbasis web ataupun aplikais khusus pembelajaran. Demikian hasil dari penelitian menunjukkan bahwa media evaluasi digital dapat meningkatkan minat dan motivasi belajar siswa serta dalam penggunaannya sangat membantu guru untuk menyampaikan materi pembelajaran dengan interaktif.

Kata Kunci: efektivitas, media evaluasi, digital
Potencial natural à erosão na sub-bacia hidrográfica do córrego Rico, no município de Muniz Freire (ES)
Authors: Fiorese Caio Henrique Ungarato , Aguilar Tiago Oliveira de
Published: September 2022

O objetivo deste estudo foi avaliar a erosão potencial na sub-bacia hidrográfica do córrego Rico (BHCR), a fim de subsidiar melhorias em conservação ambiental e produtividade econômica. Os procedimentos ocorreram no programa ArcGIS®, com auxílio de um banco de dados geográficos. Foi delimitada a BHCR com auxílio de Modelo Digital de Elevação. O potencial erosivo foi estimado através da Equação Universal de Perda dos Solos, com os parâmetros: decli- vidade, comprimento de rampa, erodibilidade e erosividade. A erosão foi quantificada, classifcada e mapeada. A classe de erosão mais abrangente é a “forte”. Porém, as classes “moderada a forte” a “muito forte” contabilizam 91,841%. As perdas de solo variam de 6,933 ton/ha.ano a 12173,283 ton/ha.ano, com média aritmética de 1715,276 ton/ ha.ano e desvio padrão igual a 792,560 ton/ha.ano. Tais resultados indicam alta tendência à perda de solos, podendo causar perdas associadas a um planejamento incorreto das atividades rurais. O emprego de técnicas conservacionistas, a correta ocupação antrópica e manutenção da cobertura vegetal são medidas de extrema relevância para a BHCR.
Toksisitas PC Gamers Terhadap Release Eksklusivitas Epic Games Store di Steam Discussion
Authors: Jahja Hartanto , Isnaini Muhamad
Published: September 2022

Eksklusivitas merupakan hal yang sangat langka di komunitas game PC, dan langkah yang dilakukan oleh Epic Games, menciptakan konflik yang baru di platform PC. Karena Steam memiliki user mayoritas di platform PC, banyak PC Gamers yang tidak dapat membeli gim baru yang mereka inginkan di dalam aplikasi store yang mereka sudah pakai sejak lama dan sukai, karena banyak yang beralih eksklusif ke Epic Games. Forum diskusi dan halaman ulasan yang seharusnya membahas hal seputar gim tersebut menjadi platform untuk menyampaikan kritik dan amarah para PC Gamers karena mereka tidak setuju dengan langkah penerbit dan pengembang. Dengan Maksim Percakapan Grice dan metode Analisis Percakapan, peneliti ingin melihat ragam jenis pelanggaran dan implikasi yang muncul di dalam percakapan forum di Steam Discussion HITMAN 2. Hasil analisis menunjukkan bahwa setiap maksim yang dilanggar memunculkan implikasi tersendiri dan percakapan pun berubah menjadi perdebatan yang toksik diantara para pengguna yang pro dan kontra. Selama Epic Games masih membuka pintu bagi para pengembang gim untuk release eksklusif di aplikasi peluncur mereka, perdebatan toksik tidak akan berhenti.
Analisis Semiotika Iklan Layanan Pencegahan Narkoba
Authors: Hakim Lukman , Ningsih Sheila Fitria
Published: September 2022

Kasus penyalahgunaan narkoba selalu terjadi setiap tahun. Akses mendapatkan narkoba semakin mudah, akibatnya penyebaran narkoba menjadi semakin luas, padahal pencegahan narkoba telah dilakukan pada semua kalangan, mulai dari anak-anak hingga dewasa. Penelitian ini membahas upaya pencegahan narkoba yang dilakukan pemerintah melalui Iklan Layanan Masyarakat (ILM). Iklan menjadi metode kampanye yang digunakan untuk menjangkau generasi muda. Kreativitas menyusun iklan yang menarik menjadi kata kunci agar pesan anti narkoba dapat dipahami dengan baik. Salah satunya melalui Iklan Layanan Masyarakat Stop Narkoba: “Kita Udah Gak Bisa Bareng Lagi” yang ditayangkan di stasiun televisi. Penelitian ini menggunakan metode kualitatif dengan pendekatan analisis semiotika yang dibawakan oleh Ferdinand De Saussure. Pengumpulan data penelitian dilakukan dengan cara memahami ILM pada kanal Youtube. Hasil penelitian ini menunjukkan iklan tidak hanya menjadi upaya pencegahan, namun iklan juga menjadi sumber informasi tentang dampak negatif yang disebabkan oleh narkoba termasuk efek sosial, kesehatan mental dan fisik yang dapat mengakibatkan kematian.
Confidentiality Preserving Instant Runoff Voting System
Authors:   CSE Department, GITAM Institute Of Technology, GITAM University, Visakhapatnam, Kharat Reena , Naidu P.Sanyasi ,   CSE Department, GITAM Institute Of Technology, GITAM University, Visakhapatnam, Chattar Shital ,   Computer Department, Pimpri Chinchwad College of Engineering, Pune, India.
Published: September 2022

Voting is a mandatory application in any democratic country for decision making. The E-voting gives the promise or confidence of giving or delivering a convenient, straight forward and economical results. E-Voting system used many cryptographic methods to reduce the security problems in the election process. Voting is one of the essential activity which is used in various applications from student’s secretory elections, reality television shows, to national elections. With the goal of better efficiency, scalability, speed and lower cost, voting is currently changed from paper based to the use of electronic medium. This is targeted to meet better security, such that voting result gives true opinion of the voters. As of late in cryptography a few changes enable us to run troublesome calculations inside the encoded area. In democratic countries like India, Instant Runoff voting method is used in election of the President of India. In IRV, voter can vote by ranking the candidates in order of preference. To protect voter’s privacy, encryption is mostly used to ensure security in open network such as the internet. The cryptosystem based on Elliptic curve cryptography (ECC) is becoming the latest technology of public key cryptography. In proposed E-voting system, voter’s confidentiality is maintained by ECC, blind signature is used for ballot anonymity and authentication. This proposed scheme will effectively ensure confidentiality, anonymity and integrity of ballot in instant runoff voting method.
Perancangan Teknologi Hybrid Berbasis Energi Turbin Kinetik dan Energi Surya
Authors: Albari Indi , Sumarjo Jojo , Hanifi Rizal
Published: September 2022

Kampung regency parakan, desa cikampek utara, kabupaten karawang merupakan daerah yang memiliki banyak aliran sungai kecil dan debit air yang bervariasi dimana pemanfaatannya belum optimal. Teknologi Hybrid berbasis Turbin Kinetik dan Energi Surya merupakan alternative sumber energi listrik yang tepat untuk dikembangkan sebagai penerangan jalan umum. Dari hasil perhitungan perancangan turbin kinetik daya perancangan generator didapatkan yaitu sebesar 16,5 watt perjam pada saat turbin kinetik bekerja selama 12 jam, sedangkan jika turbin bekerja selama 24 jam maka daya perancangan generator sebesar 8,25 watt perjam. Didapatkan perancangan daya panel surya dari setiap intesitas matahari mulai dari jam 10:00 â€“ jam 14:00 yaitu sebesar 39,6 watt perjam (watt peak). Maka didapatakan hasil dari kedua perancangan yaitu kemampuan daya optimum turbin kinetik dan panel surya saling membeckup yaitu menggunakan 3 lampu LED 5 watt selama 10 jam dengan daya sebesar 150 watt pada penggunaan turbin bekerja selama 24 jam dan penggunaan panel surya bekerja selama 5 jam mulai dari jam 10:00 â€“ jam 14:00.
Electronic Application of Bartocar In Chronic Renal Failure Patients: A Literature Review
Authors: Arifatul Diktina Amalia , Arofiati Fitri
Published: September 2022

Chronic Renal Failure (CRF) is a slow, progressive and irreversible decline in renal function can lead to the inability of the kidneys to dispose of residual waste products and unable to maintain fluid and electrolyte balance. Hemodialysis treatment measures performed on CRF patients in order to survive. Fluid monitoring in CRF patients using telemonitoring (remote monitoring equipment), the application contains fluid control and diet to facilitate patients at home. To find out the nutritional monitoring of Chronic Renal Failure patients using the electronic application of bartocar (nutritional fluid monitoring sheet). In this literature review were use 3 data bases namely proquest, pubmed and google scholar, he last 5 years from 2016-2020. Inclusion criteria: Quantitative, qualitative and mix method research design, have communication tools such as mobile phones/computers, Based via online (smartphones and websites), Chronic renal failure undergoing hemodialysis, Free, the last 5 years 2016-2020. Exclusion criteria: Paid journals, Patients undergoing hemodialysis. From the results of the journal search obtained 35,944 English journals discussed only 10 journals discussed different topics.  Electronic bartocar (fluid monitoring sheet) in patients very helpful to facilitate diet, restriction of incoming and outgoing fluids and nutrients. This mHealth app is designed to help with early diagnosis of CRF and self-monitoring. This app can be accessed via online, android 4.0/ios mobile web application and website app. Bartocar serves to help monitoring fluids and nutrients in chronic renal failure patients at home.
Good Corporate Governance Organs, Company Size and Its Effect on Earnings Quality with Earnings Management as an Intervening Variable in Manufacturing Companies listed on the Indonesia Stock Exchange in 2016-2020
Authors: Lukmanul Hakim Wildan
Published: September 2022

The research that the researcher conducted has the intention of testing the effect of managerial ownership, institutional ownership, audit committee, the proportion of independent commissioners, and firm size on earnings quality. The intervening variable in this study is earnings management with empirical studies on companies that are included in the IDX list for the 2016-2020 period. There are 193 companies that the researchers made as the population in the research that the researchers held. Purposive sampling is a sampling technique used by researchers and obtained as many as 28 companies as samples. The research carried out by researchers utilizes secondary data taken from annual reports obtained from the Indonesia Stock Exchange or company websites in the 2016-2020 period. The model used in the research is panel data regression using the Eviews 9 application. The results of the research are managerial ownership, institutional ownership, audit committee, and the proportion of independent commissioners simultaneously giving effect to earnings management and earnings quality. In addition, all variables have a significant partial effect on earnings management and earnings quality, except for the proportion of independent commissioners that does not have a significant effect on earnings quality. The mechanism of Good Corporate Governance in this study has a significant effect on earnings quality with earnings management as an intervening variable. However, firm size does not have a significant effect on earnings quality with earnings management as an intervening variable.
Transforming Social Behavior in Society through the Implementation of Digital Literacy
Authors: B. Ngenget Edmundus
Published: September 2022

Globalization is a necessity that cannot be avoided, as well as the rapid flow of technology. So, people must be able to react wisely. This is because, if people are not digital literate and blind to digital literacy, the easy situation will actually become a boomerang for themselves and others, such as the occurrence of various crime cases in online and offline media. Digital literacy is predicted to be able to overcome problems regarding various ignorance in utilizing digital which of course affects various aspects. For this reason, the researcher wants to find out more about the transformation of social behavior in society through digital implementation. The method used is descriptive quantitative by selecting respondents through purpose sampling which is adjusted to the research objectives, then the process of obtaining data using surveys which are distributed to all respondents. In addition to surveys, observation and interviews are also used to increase the validity of the research results. The results of the study show that the transformation of social behavior goes from bad to better which is seen from the mindset and culture and then forms social behavior in the community that seems to have changed. Where they can think more critically, improve the quality of culture and not be careless when they behave, they also help to harmonize society through the social behavior displayed.
Analysis of Determinants of Coffe Grower’s Decisions to Participate in Fores and Land Rehabilitation Programs in Lengkiti Sub District, Ogan Komering Ulu District
Authors: Karlina Cynthia , Sjarkowie Fachrurrozie , Minha Amruzi
Published: September 2022

This study analyzes internal factors (income, expenditure, land area, education, availability of labor, age and location) and external factors (transportation, communication, market, capital). Where internal and external factors can affect the participation of farmers in forest and land rehabilitation programs in Lengkiti District, Ogan Komering Ulu Regency. The approach model in this research is statistical analysis. The data processing in this research uses SPSS 26 with binary logistic regression analysis. The results showed that 120 coffee farmers from the selected sample, it was known that 53 coffee farmers participated in the Forest and Land Rehabilitation Program in Lengkiti District, Ogan Komering Ulu Regency, as many as 67 coffee farmers who did not participate in the Forest and Land Rehabilitation Program in Lengkiti District. Ogan Komering Ulu Regency classified by the model is 55.8%. The variables that affect the participation of farmers in the forest and land rehabilitation program are the income variable (X1) with a sig value of .025, the land area variable (X3) with a sig value. .026, and the location variable with a value of sig. .014.
The Effect Of Understanding Regional Financial Accounting Systems, Regional Financial Management And Accountability On Opd Performance With Supervision As Moderating Variables In
Authors: Morita Rahel Promovenda Bella , Br Bukit Rina , Gaddafi Muammar
Published: September 2022

The changes that have taken place since the beginning of the 1998 reform have brought changes to national development, including the performance of the regional organization (OPD) with supervision as a moderating variable in the provincial Government of North Sumatra. Population of this research is the Budget User Authority, the Technical Activities Executive Officer, Financial administration officer across the regional working units. The sampling technique used is the saturated sampling technique. The number of OPD is  The hypotheses were analyzed using the Structural Equation Model (SEM) method with the help of SmartPLS 3.0 software. The results of this study were the understanding of the regional financial accounting systems,regional property management, accountability influence the Regional Working Unit Performance simultaneously. Supervision has no positive effect and does not significantly moderate the influence of Regional Financial Management on Performance OPD the Provincial Government of North Sumatra
Relational Thinking And Problem Solution Strategies Beginning Algebra High School Students
Authors: Pandapotan Nainggolan Sahat
Published: September 2022

Many students' difficulties in learning early algebra are associated with deficiencies in learning during the student's transition from arithmetic to algebra. relational thinking; a way of thinking that can be a gateway to algebraic thinking, is touted as one of the solutions to these difficulties. This study aims to determine the profile of relational thinking and early algebra problem solving strategies for junior high school students. Through the phenomenological design, the researcher selected six participants who fit the research criteria. The data analyzed refers to several theoretical frameworks on relational thinking from several experts. This study focuses on the indicators of interpreting the equals sign , using the relationship between numbers and applying the basic properties of number operations, as well as the methods students use in solving initial algebraic problems (algebraic forms and linear equations of one variable). As a result and its implication, students' relational thinking is seen in several items, namely the first 3 indicator items: each item is seen in S1, S4, and S6; The second 2 indicator items are visible on the S4; and the third 3 indicator items are seen in S1. The majority of subjects do computing dominantly and or apply the nature of operations based on procedural knowledge. Similarly, in solving early algebra problems, it was found that the dominant tendency of students to consider algebraic expressions from a procedural perspective rather than a structural perspective (based on mathematical concepts or structures). From these results, it is deemed necessary to develop relational thinking since students study arithmetic in elementary school, including by familiarizing students with number sentences in various forms and encouraging understanding of mathematical structures (relationships between elements and understanding of the nature of number operations).
Reminiscencia y musicoterapia como intervenciones no farmacológicas en pacientes con demencia y cuidadores familiares
Authors: Birigay Mínguez Celia , Corcuera de Velasco Jaime
Published: September 2022

El presente estudio hace un abordaje sistemático sobre la importancia de trabajar con los adultos mayores que presentan algún tipo de demencia (deterioro cognitivo leve, Alzheimer, etc.), centrándonos en dos Terapias No Farmacológicas (TNF): reminiscencia positiva y musicoterapia, siendo este el principal objetivo de estudio. La base de este artículo está en la búsqueda activa de investigaciones que demuestran la eficacia del aumento del nivel cognitivo (memoria, lenguaje, concentración…) y de la disminución de la sintomatología depresiva como consecuencia de la implementación de la reminiscencia y/o musicoterapia como TNF, así como en la salud física, emocional y psicosocial de los familiares cuidadores que se ven afectados. Para ello, se ha llevado a cabo una búsqueda en Dialnet y Pubmed con un criterio temporal de 10 años, encontrando un total de 52 artículos que abordan estas TNF, siendo 18 aquellos que muestran una evidencia clara y resultados detallados sobre su eficacia. Tras llevar a cabo la presente revisión bibliográfica, se observa que las TNF son herramientas efectivas para la obtención de beneficios tanto a nivel cognitivo, conductual y emocional en pacientes y familiares; siendo alguno de ellos: la mejora del estado de ánimo y sintomatología depresiva, la calidad de vida, el fomento de la socialización y la comunicación de estos pacientes, así como la mejora en el bienestar, calidad de vida y satisfacción de los familiares cuidadores.
Escuela de padres para el desarrollo del valor del cuerpo afectivo-social, ético e intelectual
Authors: Velasco Santos Lorena , Guevara Ingelmo Raquel María , Moral García José Enrique
Published: September 2022

El presente trabajo trata de ofrecer y formar una visión holística de los valores del cuerpo mediante el diseño de una intervención dirigida a los padres de alumnos de Educación Infantil y primeros cursos de Educación Primaria. La propuesta persigue la revalorización de los valores afectivo-social, ético e intelectual del cuerpo y se fundamenta en una única metodología de trabajo, el método del caso. A través de este método se concreta, con un ejemplo familiar, las formas en que los valores del cuerpo pueden ser trasmitidos en el seno de la familia con pautas psicoeducativas específicas. La evaluación de resultados analiza el desarrollo en sí de la escuela de padres y el impacto de los contenidos abordados en dicha propuesta mediante una evaluación inicial y final. Se puede concluir que esta propuesta de intervención es muy importante para el conocimiento y desarrollo de los valores del cuerpo en diferentes dimensiones, para lo cual los padres tienen un papel esencial en el ámbito familiar, a pesar de que no siempre son conocedores de las herramientas o procedimientos adecuados para el desarrollo y fomento más eficaz de valores en sus hijos.
Provención, prevención y solución del conflicto humano desde las prácticas restaurativas
Authors: Rebollo Revesado Sonia
Published: September 2022

La vida humana está repleta de conflictos. A diario surgen todo tipo de controversias que las personas resuelven por sí mismas. Sin embargo, existen situaciones que son de difícil solución y por eso, se requiere la intervención de terceros, generalmente, se acude a jueces y tribunales. Esta hiperjudicialización de la vida diaria está provocando que algunas soluciones no se adapten a las necesidades reales de las partes y que el conflicto no resuelto se encone y cronifique hasta provocar un escalamiento y agravación del mismo. Cada vez surgen más voces que proponen el recurso a métodos adecuados de resolución de discrepancias en materia civil y mercantil y a la justicia restaurativa en materia penal. Sin embargo, hay una forma de luchar contra la judicialización de nuestra vida y es con la educación. La formación de los menores debe orientarse a la provención y a la prevención de los conflictos, como inversión necesaria para reducir, a futuro, la actual hiperlitigiosidad en España. Una forma efectiva de educar es acudiendo la filosofía restaurativa acuyos ejes centrales son la responsabilización y la reparación para conseguir la paz social.
Clinical observation of pneumomediastinum in a case of severe COVID-19-associated pneumonia in a teenager
Authors: Knizhnikova E. V. , Evseeva G. P. , Cherezov S. A. , Adlivankina T. M. , Telepneva R. S. , Suprun S. V. , Lebedko O. A.
Published: September 2022

Aim. Demonstration of the clinical case of pneumomediastinum in a teenager with severe COVID-19- associated pneumonia.Materials and methods. The clinical case of spontaneous pneumomediastinum was presented, which was a complication of the severe course of COVID-19 pneumonia in a teenager.Results. Patient Ch., 15 years old, with obesity of the 1st degree, was admitted to the hospital of infectious diseases for patients with a COVID-19 on the 7th day of the illness in a severe condition and had complaints of an increase in body temperature to 40ºC, pronounced cough and weakness, dyspnea when walking and at rest. The PCR test for SARS-CoV-2 gave a positive result. Multispiral computed tomography showed polysegmental interstitial lesion of both lungs, which had multiple areas of “ground glass”, signs of pneumomediastinum, subcutaneous emphysema of the upper third of the chest, left-sided pleural effusion. The volume of lung tissue lesion was 50% on the right and 85% on the left. The positive effect of treatment was not observed after 2-3 days in the hospital. The condition of heavy severity continued due to intoxication syndrome, respiratory failure, inflammatory changes in lung tissue syndrome. In this regard, the patient was injected intravenously with tocilizumab (Actemra®) 400 mg. The child was released on the 20th day of hospitalization with a positive clinical effect.Conclusion. The above clinical case demonstrates that in children a novel coronavirus infection can occur not only in severe form, but also with the possible development of complications in the form of pneumomediastinum and low effectiveness of antibacterial and antiviral therapy, which required the use of humanized monoclonal antibodies (tocilizumab).
Neutrophil extracellular traps in the pathogenesis of obstetric complications in COVID-19 (brief review)
Authors: Zhukovskaya O. V.
Published: September 2022

Introduction. In the pathogenesis of the new coronavirus infection (COVID-19), innate cellular elements of the immune system are of great importance, among which special attention is paid to neutrophils and the mechanisms of their death – netosis, which leads to the formation of extracellular DNA traps. Neutrophil extracellular traps play an important role in the development of endothelial dysfunction and thrombotic disorders, which not only complicates the course of COVID-19 infection, but also causes severe obstetric complications that increase the risk of maternal and infant mortality. This review describes possible mechanisms for the formation of neutrophil extracellular traps, as well as their role in the pathogenesis of COVID-19.Materials and methods. An analysis of Russian (eLibrary) and foreign (PubMed) literature was carried out with a search depth of 2010-2021.Results. The pathogenesis of COVID-19 is directly related to the uncontrolled progression of systemic inflammation, which changes the innate immune response in the form of functional maladaptation and premature death of neutrophils with the formation of neutrophil extracellular traps. The neutrophils that were transformed by netosis play a key role in the development of thrombotic disorders of the microvasculature, which leads to the development of life-threatening complications such as acute respiratory distress syndrome and multiple organ failure, which increases the mortality of patients with COVID-19 infection. During pregnancy, increased formation of neutrophilic extracellular traps is the cause of hemodynamic disturbances of the fetoplacental complex, placental disorders and endothelial dysfunction, concomitant with the development of preterm labor and preeclampsia, which increases the risk of postpartum hemorrhage, maternal morbidity and mortality. Therefore, new data on neutrophil extracellular traps and mechanisms of formation may lead to a reconsideration of the pathogenesis of thrombotic disorders in pregnant women with COVID-19 infection, which is important for further management of pregnancy.
Detection of chronic obstructive pulmonary disease biomarkers using ROC-analysis
Authors: Vitkina T. I. , Kondratyeva E. V.
Published: September 2022

Aim. To identify key diagnostic criteria for chronic obstructive pulmonary disease (COPD).Materials and methods. We examined 112 patients with mild, moderate and severe COPD and 32 relatively healthy volunteers with no disturbances in the lung function. The level of IL-4, IL-6, IL-10, IL-17A, TNF-α, IFN-γ, TGF-β1 and CD4+CD126+ cells was determined by means of flow cytometry method. Prooxidant and antioxidant markers of oxidative stress 8-OHdeoxyguanosine, protein carbonyl, glutathione, glutathione reductase, glutathione peroxidase, thioredoxin-1, and thioredoxin reductase-1 were assessed by enzyme immunoassay.Results. The presence of high-ranking correlations of the proinflammatory link of immunity and components of the prooxidant system was revealed, which indicates the presence of systemic alterative processes in patients with COPD. Based on ROC-analysis, key biomarkers were identified in patients with stable COPD: 8-OH-deoxyguanosine, CD4+CD126+ cells, IL-17, and thioredoxin, and their threshold levels were established.Conclusion. The recommended diagnostic criteria will optimize the therapeutic strategies for COPD.
Evaluation of the involvement of PPARG2 gene rs1801282 polymorphism in the pathogenesis of bronchial asthma with obesity in children
Authors: Telepneva R. S. , Evseeva G. P. , Nagovitsyna E. В. , Suprun E. N. , Khaletskaya N. I. , Suprun S. V. , Lebedko O. A.
Published: September 2022

Introduction. Features of the clinical course of bronchial asthma in children with obesity made it possible to identify a special phenotype, when the presence and severity of obesity determine a more severe course of asthma and a worse response to asthma therapy. Asthma, like obesity, is recognized as a classic example of multifactorial diseases, which are based on a rather complex gene network. Studying the genetic basis of both of these complex traits and linking them to the asthma phenotype should contribute to our understanding of the overall genetic basis of these pathological disorders.Aim. Evaluation of the clinical and genetic significance of the rs1801282 polymorphism of the PPARG2 gene (34C>G, p.Pro12Ala) in children with asthma and obesity.Materials and methods. 161 children with asthma were examined, including 59 patients with obesity 1-3 degrees. The examination included general clinical, functional, instrumental methods. The level of asthma control was determined according to the GINA criteria (2018). The study of gene polymorphisms was carried out by the real-time polymerase chain reaction.Results. An analysis of the frequencies of the PPARG2 gene polymorphism in children with bronchial asthma did not reveal any differences from the control group healthy people. In 61% of children with asthma and obesity, there was no control over the disease, which was associated with the G allele (OR 2.4 [95% CI: 1.09‒5.30], p=0.0281). An increase in the activity of lactate dehydrogenase and a decrease in the membrane potential of mitochondria in peripheral blood lymphocytes in children with the GG genotype were revealed, which may indirectly affect the level of disease control.Conclusion. The comorbidity of asthma and obesity in children affects the control of the disease. This manifests itself through immune mechanisms that play a key role in energy homeostasis and mitochondrial dysfunction of immunocompetent blood cells. The G-allele of the PPARG2 gene can be a marker of the lack of control over the disease in obese children with asthma. The pathogenetic significance of this polymorphism requires further study.
Features of psychophysiological status and level of myocardial stress in wrestlers with masked hypertension
Authors: Mestnikova E. N.
Published: September 2022

Aim. To reveal the features of the psychophysiological status and the level of myocardial stress in wrestlers with masked hypertension.Materials and methods. We examined 125 athletes, aged 18 to 30, male, Yakut nationality, high sportsmanship (candidate master of sports, master of sports). Depending on the level of blood pressure, athletes were divided into 2 groups: group 1 ‒ athletes with normal blood pressure (n=80, 64.0%); group 2 ‒ athletes with masked hypertension (n=45, 36.0%). A clinical examination, anthropometry, measurement of office and daily blood pressure levels, echocardiography of the left ventricle were performed.Results. In athletes with masked hypertension, a high level of reactive anxiety prevails, which increases the relative chance of developing hypertension by 2.6 times (OR 2.601 [95% CI: 1.123‒6.023], p<0.05), a sympathicotonic type of regulation of the cardiovascular system was noted, an increase in systolic myocardial stress and high levels of left ventricular wall thickness compared with athletes with normal blood pressure.Conclusion. High reactive anxiety can serve as a risk factor for the development of masked hypertension in athletes. A comprehensive assessment of the psychophysiological status and individual typological characteristics of athletes is necessary to prevent the development of prepathological and pathological changes in the cardiovascular system in athletes.
DILATED CARDIOMYOPATHY IN A PATIENT WITH CHRONIC HEPATITIS C: A CLINICAL CASE
Authors: Гончарова Анна Юрьевна , Титова Лилия Александровна , Толстых Елена Михайловна , Суслова Екатерина Юрьевна
Published: September 2022

Кардиомиопатии - группа заболеваний сердца различной этиологии. При дилатационной кардиомиопатии, проявляющейся расширением полости и систолической дисфункцией левого желудочка или обоих желудочков без влияния гемодинамических факторов, причины развития патологии могут лежать как в генетических мутациях, так и в инфекционном поражении миокарда, в том числе вирусами различных семейств. В связи с большим вкладом дилатационной кардиомиопатии в заболеваемость, инвалидизацию и смертность необходимо изучение способов диагностики данной патологии для максимально раннего выявления, в том числе диагностических возможностей различных лучевых методов визуализации сердца. При хроническом гепатите C существует возможность развития и прогрессирования поражения миокарда за счет прямого и непрямого иммуноопосредованного действия вируса. Был рассмотрен клинический случай диагностики проявлений дилатационной кардиомиопатии у пациента с хроническим гепатитом C, обратившегося за медицинской помощью в связи с возникшими жалобами кардиологического характера, проведен анализ данных истории болезни пациента, изучены результаты лабораторных исследований (общий и биохимический анализ крови, ИФА anti-HCV, ПЦР HBs Ag) и применявшихся методов визуализации (УЗИ органов брюшной полости, УЗИ плевральных полостей, УЗДГ вен нижних конечностей, Эхокардиография, ЭКГ)

Cardiomyopathies are a group of heart diseases of various etiologies. In dilated cardiomyopathy, manifested by cavity expansion and systolic dysfunction of the left ventricle or both ventricles without an influence of hemodynamic factors, causes of development of the pathology can lie both in genetic mutations and in infectious myocardial damage, including viruses of various families. Due to large contribution of dilated cardiomyopathy to morbidity, disability and mortality, it is necessary to study the methods for diagnosing this pathology for the earliest possible detection, including the diagnostic capabilities of various radiologic methods of cardiac imaging. In chronic hepatitis C, there is a possibility of development and progression of myocardial damage due to direct and indirect immune-mediated action of the virus. A clinical case of diagnosing dilated cardiomyopathy manifestations in a patient with chronic hepatitis C, who sought medical help due to cardiac complaints, was analyzed. The patient's medical history was reviewed also as the results of laboratory tests (CBC and blood chemistry, anti-HCV ELISA, PCR HBs Ag) and imaging methods used (abdominal organs ultrasound, pleural cavities ultrasound, ultrasound of the lower extremities veins, echocardiography, ECG)
RESEARCH OF GENETIC PREDISPOSITION, RISK FACTORS AND THE DEVELOPMENT OF MALIGNANT NEOPLASMS AMONG ADULT POPULATION (ON THE EXAMPLE OF THE VORONEZH REGION)
Authors: Данилов Валерий Михайлович
Published: September 2022

Решение проблемы снижения онкологической заболеваемости населения является одной из приоритетных для современного здравоохранения. При этом особую значимость имеет первичная профилактика злокачественных новообразований, направленная на выявление и устранение этиологических факторов. Проведенное исследование направлено на выявление взаимосвязи генетической предрасположенности, факторов риска и развития злокачественных новообразований. На основе специально разработанной анкеты проведен опрос 993 респондентов в возрасте от 18 до 85 лет, проживающих на территории Воронежской области. В ходе исследования установлено достоверно более частое развитие онкологических заболеваний у женщин с нормальным или увеличенным весом и курящих мужчин, имеющих фоновые предраковые заболевания во взаимосвязи с генетической предрасположенностью к развитию злокачественных новообразований. Полученные результаты позволили научно обосновать предложения по совершенствованию организации профилактики и раннего выявления онкологических заболеваний, которые могут быть реализованы на региональном уровне

One of the priorities for modern healthcare is finding a solution for the problem of reducing the cancer morbidity. However, primary prevention of malignant neoplasms is of particular importance, aimed at identifying and eliminating etiological factors. The conducted research is aimed at identifying the relationship of genetic predisposition, risk factors and the development of malignant neoplasms. According to a specially developed questionnaire, a survey of 993 respondents aged 18 to 85 years living in the Voronezh Region was conducted. The study found significantly more frequent development of cancer diseases in women with normal or increased weight and smoking men with background precancerous diseases in connection with a genetic predisposition to the development of malignant neoplasms. The obtained results allowed us to scientifically substantiate proposals for improving the organization of prevention and early detection of cancer diseases, which can be implemented at the regional level
Most Favored Racial Hierarchy: The Ever-Evolving Ways of the Supreme Court’s Superordination of Whiteness
Authors: Simson David
Published: September 2022

This Article engages in a critical comparative analysis of the recent history and likely future trajectory of the Supreme Court’s constitutional jurisprudence in matters of race and religion to uncover new aspects of the racial project that Reggie Oh has recently called the “racial superordination” of whiteness—the reinforcing of the superior status of whites in American society by, among other things, prioritizing their interests in structuring constitutional doctrine. This analysis shows that the Court is increasingly widening the gap between conceptions of, and levels of protection provided for, equality in the contexts of race and religion in ways that prioritize the interests of whiteness and set those interests as the normative baseline in both areas of constitutional law. While the Court has increasingly moved toward an aggressive and religion-conscious “most favored nation” equality theory in the Free Exercise Clause context, its continued march toward mandating colorblindness is arguably moving toward something akin to a “least favored nation” equality theory for race and race consciousness in the equal protection context. Arguments can be made that the most favored nation approach should also be applied to race. Doing so would provide more doctrinal space for racial equality-enhancing government programs and call into question deeply entrenched aspects of the Court’s current affirmative action jurisprudence. The Court’s refusal to even hint at the possibility of such an approach points to a racial project of superordinating the interests of white Americans to be constitutionally protected from race-conscious interference with their dominant position in the racial hierarchy over the application of consistent constitutional principles.
The Cossack law of the Hetmanate as a political and legal pheno menon
Authors: Makarchuk Volodymyr , Terliuk Ivan , Lytvynenko Anatoliy
Published: September 2022

Cossack law, as a legal system, is researched by the authors, as a civilizational phenomenon of Ukrainian history, as well as anentirely Ukrainian national-political and legal phenomenon, inseparable from the Cossack state, which had been the apogee of evolutionof which belongs to the times of the Hetmanate. It is emphasized that the origins of the process of origination of Ukrainian law itself,that is, the time when its original difference from the laws of neighboring states – Poland, Moscow, Ottoman Empire, etc., and belongsto the period of the Hetmanate (in particular, its initial stage of the Khmelnytskiy region). The thesis, which is argued by the authors ofthe article is that the decisive influence on the formation of the Ukrainian legal system at that time was, in fact, the civilizational choiceof the representatives of all social strata of the land population under the Hetman’s jurisdiction in favor of consolidating the basic principlesof Cossack philosophy reflecting a peculiar system of values in the arrangement of the society, including freedom, equity, equa -lity and public interest. Arguments of the authors are presented indicating the beginning of a new quality of Ukrainian Cossack law –in contrast to the former corporate one; it is becoming a sign of Ukrainian national law owing to the change in social nature. And thisquality, in general, could not be undermined by the changes of the dominant in the application of the homegrown and externallyimposed rights that fell to the decline of the Cossack-Hetman state, the last quarter of the 17the century and, in fact, throughout thewhole 18th century as well. It is concluded, that one of the consequences of the Cossack influence on the societal legal relations wasthe fact that the population of the Hetman region actually outstripped its historical time of pre-bourgeois societal relations.