bluuebunny/crossref_metadata_2025 huggingface dataset:
Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study
Authors: Uema Deise , Alves Carolina , Mesquita Marcella , Nuñez Jose Eduardo , Siepmann Timo , Angel Martin , Rego Juliana F. M. , Weschenfelder Rui , Rocha Filho Duilio R. , Costa Frederico P. , Barros Milton , O’Connor Juan M. , Illigens Ben M. , Riechelmann Rachel P.
Published: March 2019

The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted of factors associated with CHD in advanced NET pts with carcinoid syndrome (CS) and/or elevated urinary 5-hidroxyindole acetic acid (u5HIAA). CHD was defined as at least moderate right valve alterations. The results were the following: Among the 139 subjects included, the majority had a midgut NET (54.2%), 81.3% had CS, and 93% received somatostatin analogues. In a median follow-up of 39 months, 48 (34.5%) pts developed CHD, with a higher frequency in pts treated in public (77.2%) versus private settings (22.9%). In a multivariate logistic regression, unknown primary or colorectal NETs (Odds Ratio (OR) 4.35; p = 0.002), at least 50% liver involvement (OR 3.45; p = 0.005), and being treated in public settings (OR 4.76; p = 0.001) were associated with CHD. In a Cox multivariate regression, bone metastases (Hazard Ratio {HR} 2.8; p = 0.031), CHD (HR 2.63; p = 0.038), and a resection of the primary tumor (HR 0.33; p = 0.026) influenced the risk of death. The conclusions were the following: The incidence of CHD was higher in pts with a high hepatic tumor burden and in those treated in a public system. Delayed diagnosis and limited access to effective therapies negatively affected the lives of NET patients.
Smoking Dependent Alterations in Bone Formation and Inflammation Represent Major Risk Factors for Complications Following Total Joint Arthroplasty
Authors: Ehnert Sabrina , Aspera-Werz Romina H. , Ihle Christoph , Trost Markus , Zirn Barbara , Flesch Ingo , Schröter Steffen , Relja Borna , Nussler Andreas K.
Published: March 2019

Numerous studies have described a correlation between smoking and reduced bone mass. This not only increases fracture risk but also impedes reconstruction/fixation of bone. An increased frequency of complications following surgery is common. Here, we investigate the effect of smoking on the clinical outcome following total joint arthroplasty (TJA). 817 patients receiving primary or revision (including clinical transfers) TJA at our level-one trauma center have been randomly interviewed twice (pre- and six months post-surgery). We found that 159 patients developed complications (infections, disturbed healing, revisions, thrombosis, and/or death). Considering nutritional status, alcohol and cigarette consumption as possible risk factors, OR was highest for smoking. Notably, mean age was significantly lower in smokers (59.2 ± 1.0a) than non-smokers (64.6 ± 0.8; p < 0.001). However, the number of comorbidities was comparable between both groups. Compared to non-smokers (17.8 ± 1.9%), the complication rate increases with increasing cigarette consumption (1–20 pack-years (PY): 19.2 ± 2.4% and >20 PY: 30.4 ± 3.6%; p = 0.002). Consequently, mean hospital stay was longer in heavy smokers (18.4 ± 1.0 day) than non-smokers (15.3 ± 0.5 day; p = 0.009) or moderate smokers (15.9 ± 0.6 day). In line with delayed healing, bone formation markers (BAP and CICP) were significantly lower in smokers than non-smokers 2 days following TJA. Although, smoking increased serum levels of MCP-1, OPG, sRANKL, and Osteopontin as well as bone resorption markers (TRAP5b and CTX-I) were unaffected. In line with an increased infection rate, smoking reduced 25OH vitamin D3 (immune-modulatory), IL-1β, IL-6, TNF-α, and IFN-γ serum levels. Our data clearly show that smoking not only affects bone formation after TJA but also suppresses the inflammatory response in these patients. Thus, it is feasible that therapies favoring bone formation and immune responses help improve the clinical outcome in smokers following TJA.
The Impact of Corporate Diversification and Financial Structure on Firm Performance: Evidence from South Asian Countries
Authors: Mehmood Rashid , Hunjra Ahmed Imran , Chani Muhammad Irfan
Published: March 2019

We examined the impact of corporate diversification and financial structure on the firms’ financial performance. We collected data from 520 manufacturing firms from Pakistan, India, Sri Lanka, and Bangladesh. We used panel data of 14 years from 2004–2017 to analyze the results. We applied a two-step dynamic panel approach to analyze the hypotheses. We found that product diversification and geographic diversification significantly affected the firms’ financial performance. We further found that dividend policy and capital structure had a significant impact on the firm’s financial performance.
Nanocomposite of Poly(l-Lactic Acid) with Inorganic Nanotubes of WS2
Authors: Shalom Hila , Sui XiaoMeng , Elianov Olga , Brumfeld Vlad , Rosentsveig Rita , Pinkas Iddo , Feldman Yishay , Kampf Nir , Wagner H.D. , Lachman Noa , Tenne Reshef
Published: March 2019

Composites of poly(l-lactic acid) (PLLA) reinforced by adding inorganic nanotubes of tungsten disulfide (INT–WS2) were prepared by solvent casting. In addition to the pristine nanotubes, PLLA nanocomposites containing surface modified nanotubes were studied as well. Several surface-active agents, including polyethylene imine (PEI), were studied in this context. In addition, other biocompatible polymers, like poly d,l-lactic acid (PDLLA) and others were considered in combination with the INT–WS2. The nanotubes were added to the polymer in different proportions up to 3 wt %. The dispersion of the nanotubes in the nanocomposites were analyzed by several techniques, including X-ray tomography microscopy (Micro-XCT). Moreover, high-temperature rheological measurements of the molten polymer were conducted. In contrast to other nanoparticles, which lead to a considerable increase of the viscosity of the molten polymer, the WS2 nanotubes did not affect the viscosity significantly. They did not affect the complex viscosity of the molten PLLA phase, either. The mechanical and tribological properties of the nanocomposites were found to improve considerably by adding the nanotubes. A direct correlation was observed between the dispersion of the nanotubes in the polymer matrix and its mechanical properties.
Effect of Temperature, Pressure, and Chemical Composition on the Electrical Conductivity of Schist: Implications for Electrical Structures under the Tibetan Plateau
Authors: Sun Wenqing , Dai Lidong , Li Heping , Hu Haiying , Liu Changcai , Wang Mengqi
Published: March 2019

The experimental study on the electrical conductivities of schists with various contents of alkali ions (CA = K2O + Na2O = 3.94, 5.17, and 5.78 wt.%) were performed at high temperatures (623–1073 K) and high pressures (0.5–2.5 GPa). Experimental results indicated that the conductivities of schist markedly increased with the rise of temperature. Pressure influence on the conductivities of schist was extremely weak at the entire range of experimental temperatures. Alkali ion content has a significant influence on the conductivities of the schist samples in a lower temperature range (623–773 K), and the influence gradually decreases with increasing temperature in a higher temperature range (823–1073 K). In addition, the activation enthalpies for the conductivities of three schist samples were fitted as being 44.16–61.44 kJ/mol. Based on the activation enthalpies and previous studies, impurity alkaline ions (K+ and Na+) were proposed as the charge carriers of schist. Furthermore, electrical conductivities of schist (10−3.5–10−1.5 S/m) were lower than those of high-conductivity layers under the Tibetan Plateau (10−1–100 S/m). It was implied that the presence of schist cannot cause the high-conductivity anomalies in the middle to lower crust beneath the Tibetan Plateau.
Variation of the Pore Morphology during the Early Age in Plain and Fiber-Reinforced High-Performance Concrete under Moisture-Saturated Curing
Authors: Vicente Miguel A. , Mínguez Jesús , González Dorys C.
Published: March 2019

In this paper, two concrete mixtures of plain concrete (PC) and steel fiber-reinforced high-performance concrete (SFRC) have been scanned in order to analyze the variation of the pore morphology during the first curing week. Six cylinders of 45.2-mm diameter 50-mm height were performed. All of the specimens were kept in a curing room at 20 °C and 100% humidity. A computed tomography (CT) scan was used to observe the internal voids of the mixtures, and the data were analyzed using digital image processing (DIP) software, which identified and isolated each individual void in addition to extracting all of their geometrical parameters. The results revealed that the SFRC specimens showed a greater porosity than the PC ones. Moreover, the porosity increased over time in the case of SFRC, while it remained almost constant in the case of PC. The porosity increased with the depth in all cases, and the lowest porosity was observed in the upper layer of the specimens, which is the one that was in contact with the air. The analysis of the results showed that the fibers provided additional stiffness to the cement paste, which was especially noticeable during this first curing week, resulting in an increasing of the volume of the voids and the pore size, as well as a reduction in the shape factor of the voids, among other effects.
Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review
Authors: Jin Yining , Acharya Harini G. , Acharya Devansh , Jorgensen Rick , Gao Haoran , Secord James , Ng Perry K. W. , Gangur Venugopal
Published: March 2019

The prevalence of wheat allergy has reached significant levels in many countries. Therefore, wheat is a major global food safety and public health issue. Animal models serve as critical tools to advance the understanding of the mechanisms of wheat allergenicity to develop preventive and control methods. A comprehensive review on the molecular mechanisms of wheat allergenicity using animal models is unavailable at present. There were two major objectives of this study: To identify the lessons that animal models have taught us regarding the molecular mechanisms of wheat allergenicity and to identify the strengths, challenges, and future prospects of animal models in basic and applied wheat allergy research. Using the PubMed and Google Scholar databases, we retrieved and critically analyzed the relevant articles and excluded celiac disease and non-celiac gluten sensitivity. Our analysis shows that animal models can provide insight into the IgE epitope structure of wheat allergens, effects of detergents and other chemicals on wheat allergenicity, and the role of genetics, microbiome, and food processing in wheat allergy. Although animal models have inherent limitations, they are critical to advance knowledge on the molecular mechanisms of wheat allergenicity. They can also serve as highly useful pre-clinical testing tools to develop safer genetically modified wheat, hypoallergenic wheat products, novel pharmaceuticals, and vaccines.
Ethylene Measurements from Sweet Fruits Flowers Using Photoacoustic Spectroscopy
Authors: Popa Cristina
Published: March 2019

Ethylene is a classical plant hormone and has appeared as a strong molecule managing many physiological and morphological reactions during the life of a plant. With laser-based photoacoustic spectroscopy, ethylene can be identified with high sensitivity, at a high rate and with very good selectivity. This research presents the dynamics of trace gases molecules for ethylene released by cherry flowers, apple flowers and strawberry flowers. The responses of distinctive organs to ethylene may fluctuate, depending on tissue sensitivity and the phase of plant development. From the determinations of this study, the ethylene molecules at the flowers in the nitrogen flow were established in lower concentrations when the value is correlated to the ethylene molecules at the flowers in synthetic air flow.
Base-Promoted SNAr Reactions of Fluoro- and Chloroarenes as a Route to N-Aryl Indoles and Carbazoles
Authors: Iqbal Muhammad Asif , Mehmood Hina , Lv Jiaying , Hua Ruimao
Published: March 2019

KOH/DMSO-promoted C-N bond formation via nucleophilic aromatic substitution (SNAr) between chloroarenes or fluoroarenes with indoles and carbazole under transition metal-free conditions affording the corresponding N-arylated indoles and carbazoles has been developed.
Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica
Authors: Qi Zeng , Li Zhuo , Guan Xuewa , Wang Cuizhu , Wang Fang , Li Pingya , Liu Jinping
Published: March 2019

Panax ginseng Meyer cv. Silvatica (PGS), which is also known as “Lin-Xia-Shan-Shen” or “Zi-Hai” in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15–20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (1), ginsengenin-S2 (2), ginsenoside-S3 (3), ginsenoside-S4 (4), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.
Non-Isothermal Sublimation Kinetics of 2,4,6-Trinitrotoluene (TNT) Nanofilms
Authors: Hikal Walid M. , Weeks Brandon L.
Published: March 2019

Non-isothermal sublimation kinetics of low-volatile materials is more favorable over isothermal data when time is a crucial factor to be considered, especially in the subject of detecting explosives. In this article, we report on the in-situ measurements of the sublimation activation energy for 2,4,6-trinitrotoluene (TNT) continuous nanofilms in air using rising-temperature UV-Vis absorbance spectroscopy at different heating rates. The TNT films were prepared by the spin coating deposition technique. For the first time, the most widely used procedure to determine sublimation rates using thermogravimetry analysis (TGA) and differential scanning calorimetry (DSC) was followed in this work using UV-Vis absorbance spectroscopy. The sublimation kinetics were analyzed using three well-established calculating techniques. The non-isothermal based activation energy values using the Ozawa, Flynn–Wall, and Kissinger models were 105.9 ± 1.4 kJ mol−1, 102.1 ± 2.7 kJ mol−1, and 105.8 ± 1.6 kJ mol−1, respectively. The calculated activation energy agreed well with our previously reported isothermally-measured value for TNT nanofilms using UV-Vis absorbance spectroscopy. The results show that the well-established non-isothermal analytical techniques can be successfully applied at a nanoscale to determine sublimation kinetics using absorbance spectroscopy.
Application of Solid Lipid Nanoparticles to Improve the Efficiency of Anticancer Drugs
Authors: Bayón-Cordero Laura , Alkorta Itziar , Arana Lide
Published: March 2019

Drug delivery systems have opened new avenues to improve the therapeutic effects of already-efficient molecules. Particularly, Solid Lipid Nanoparticles (SLNs) have emerged as promising nanocarriers in cancer therapy. SLNs offer remarkable advantages such as low toxicity, high bioavailability of drugs, versatility of incorporation of hydrophilic and lipophilic drugs, and feasibility of large-scale production. Their molecular structure is crucial to obtain high quality SLN preparations and it is determined by the relationship between the composition and preparation method. Additionally, SLNs allow overcoming several physiological barriers that hinder drug delivery to tumors and are also able to escape multidrug resistance mechanisms, characteristic of cancer cells. Focusing on cell delivery, SLNs can improve drug delivery to target cells by different mechanisms, such as passive mechanisms that take advantage of the tumor microenvironment, active mechanisms by surface modification of SLNs, and codelivery mechanisms. SLNs can incorporate many different drugs and have proven to be effective in different types of tumors (i.e., breast, lung, colon, liver, and brain), corroborating their potential. Finally, it has to be taken into account that there are still some challenges to face in the application of SLNs in anticancer treatments but their possibilities seem to be high.
Tantalum Oxynitride Thin Films: Assessment of the Photocatalytic Efficiency and Antimicrobial Capacity
Authors: Cristea Daniel , Cunha Luis , Gabor Camelia , Ghiuta Ioana , Croitoru Catalin , Marin Alexandru , Velicu Laura , Besleaga Alexandra , Vasile Bogdan
Published: March 2019

Tantalum oxynitride thin films have been deposited by reactive magnetron sputtering, using a fixed proportion reactive gas mixture (85% N2 + 15% O2). To produce the films, the partial pressure of the mixture in the working atmosphere was varied. The characteristics of the produced films were analyzed from three main perspectives and correspondent correlations: the study of the bonding states in the films, the efficiency of photo-degradation, and the antibacterial/antibiofilm capacity of the coatings against Salmonella. X-ray Photoelectron Spectroscopy results suggest that nitride and oxynitride features agree with a constant behavior relative to the tantalum chemistry. The coatings deposited with a higher reactive gas mixture partial pressure exhibit a significantly better antibiofilm capacity. Favorable antibacterial resistance was correlated with the presence of dominant oxynitride contributions. The photocatalytic ability of the deposited films was assessed by measuring the level of degradation of an aqueous solution containing methyl orange, with or without the addition of H2O2, under UV or VIS irradiation. Degradation efficiencies as high as 82% have been obtained, suggesting that tantalum oxynitride films, obtained in certain configurations, are promising materials for the photodegradation of organic pollutants (dyes).
The Golden Egg: Nutritional Value, Bioactivities, and Emerging Benefits for Human Health
Authors: Réhault-Godbert Sophie , Guyot Nicolas , Nys Yves
Published: March 2019

Egg is an encapsulated source of macro and micronutrients that meet all requirements to support embryonic development until hatching. The perfect balance and diversity in its nutrients along with its high digestibility and its affordable price has put the egg in the spotlight as a basic food for humans. However, egg still has to face many years of nutritionist recommendations aiming at restricting egg consumption to limit cardiovascular diseases incidence. Most experimental, clinical, and epidemiologic studies concluded that there was no evidence of a correlation between dietary cholesterol brought by eggs and an increase in plasma total-cholesterol. Egg remains a food product of high nutritional quality for adults including elderly people and children and is extensively consumed worldwide. In parallel, there is compelling evidence that egg also contains many and still-unexplored bioactive compounds, which may be of high interest in preventing/curing diseases. This review will give an overview of (1) the main nutritional characteristics of chicken egg, (2) emerging data related to egg bioactive compounds, and (3) some factors affecting egg composition including a comparison of nutritional value between eggs from various domestic species.
Determinants of Undernutrition among Young Children Living in Soth Nikum District, Siem Reap, Cambodia
Authors: Blaney Sonia , Menasria Lylia , Main Barbara , Chhorvann Chhea , Vong Lenin , Chiasson Lucie , Hun Vannary , Raminashvili David
Published: March 2019

Background: Child undernutrition is of public concern in Cambodia. An understanding of factors influencing child nutritional status is essential to design programs that will reduce undernutrition. Using the UNICEF conceptual framework of causes of malnutrition, our research investigates the relationship between nutritional status of children aged 6–23 months and its immediate and underlying determinants. Methods: Baseline data from a cluster-randomized controlled trial aiming to assess the impact of the promotion of optimal feeding practices combined or not with the provision of local foods among 360 children 6–23 months of age were used. Anthropometry and biochemical measurements were performed at baseline. Data on each determinant of undernutrition were collected through interviews and direct observations. Results: Our results show that the degree of satisfaction of proteins and zinc requirements as well as the access to improved water sources and sanitation were positively associated with length-for-age, while having a better health status and a higher degree of satisfaction of energy, protein, zinc, and iron requirements were associated to an improved weight-for-length. Only child health status was associated to ferritin. Conclusion: Our results reiterate the importance of improving child diet and health status, but also the access to a healthy environment to ensure an optimal nutritional status.
One- and Two-Year Effects of the Healthy Primary School of the Future on Children’s Dietary and Physical Activity Behaviours: A Quasi-Experimental Study
Authors: Bartelink Nina H. M. , van Assema Patricia , Kremers Stef P. J. , Savelberg Hans H. C. M. , Oosterhoff Marije , Willeboordse Maartje , van Schayck Onno C. P. , Winkens Bjorn , Jansen Maria W. J.
Published: March 2019

Schools can help to improve children’s health. The ‘Healthy Primary School of the Future’ (HPSF) aims to sustainably integrate health and well-being into the school system. This study examined the effects of HPSF on children’s dietary and physical activity (PA) behaviours after 1 and 2 years’ follow-up. The study (n = 1676 children) has a quasi-experimental design with four intervention schools, i.e., two full HPSF (focus: nutrition and PA) and two partial HPSF (focus: PA), and four control schools. Accelerometers and child- and parent-reported questionnaires were used at baseline, after 1 (T1) and 2 (T2) years. Mixed-model analyses showed significant favourable effects for the full HPSF versus control schools for, among others, school water consumption (effect size (ES) = 1.03 (T1), 1.14 (T2)), lunch intake of vegetables (odds ratio (OR) = 3.17 (T1), 4.39 (T2)) and dairy products (OR = 4.43 (T1), 4.52 (T2)), sedentary time (ES = −0.23 (T2)) and light PA (ES = 0.22 (T2)). Almost no significant favourable effects were found for partial HPSF compared to control schools. We conclude that the full HPSF is effective in promoting children’s health behaviours at T1 and T2 compared with control schools. Focusing on both nutrition and PA components seems to be more effective in promoting healthy behaviours than focusing exclusively on PA.
The Effect of Serum 25-Hydroxyvitamin D on Serum Ferritin Concentrations: A Longitudinal Study of Participants of a Preventive Health Program
Authors: Munasinghe Lalani L. , Ekwaru John P. , Mastroeni Silmara S. B. S. , Mastroeni Marco F. , Veugelers Paul J.
Published: March 2019

Various studies have suggested a role of vitamin D in inflammation. However, its effect on ferritin, a biomarker of inflammation, has received relatively little attention. Therefore, we aimed to assess the association of serum 25-hydroxyvitamin D (25(OH)D) with serum ferritin (SF) concentrations, and to examine whether temporal increases in serum 25(OH)D concentrations are paralleled by a reduction in SF concentrations. Data from a community sample of Canadian adults who participated in a preventive health program (n = 6812) were analyzed. During the follow-up, serum 25(OH)D concentrations increased from 80.7 to 115.0 nmol/L whereas SF concentrations decreased from 122.0 to 92.0 µg/L (median follow-up time was 11.67 months). Cross-sectional analyses revealed that compared to participants with 25(OH)D concentrations of <50 nmol/L, those with 25(OH)D concentrations of 75 to <100, 100 to <125, and ≥125 nmol/L had SF concentrations that were 13.00, 23.15, and 27.59 µg/L lower respectively (p < 0.001). Compared to those without temporal improvements in 25(OH)D concentrations between baseline and follow-up, participants who improved their 25(OH)D concentrations with ≥50 nmol/L decreased their SF concentrations with 5.71 µg/L. For participants for whom the increase in 25(OH)D concentrations was less than 50 nmol/L, decreases in SF concentrations were less pronounced and not statistically significant. These observations suggest that despite strong associations between 25(OH)D and SF concentrations, interventions aiming to lower SF concentrations through sun-exposure and vitamin D supplementation should target substantial increases in 25(OH)D concentrations.
Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies
Authors: Sartini Marina , Bragazzi Nicola Luigi , Spagnolo Anna Maria , Schinca Elisa , Ottria Gianluca , Dupont Chiara , Cristina Maria Luisa
Published: March 2019

Coffee is a blend of compounds related to gastrointestinal physiology. Given its popularity and the epidemiology of colorectal cancer, the impact of this beverage on public health could be considerable. Our aim was to provide an updated synthesis of the relationship between coffee consumption and the risk of colorectal cancer. We conducted a systematic review and meta-analysis of 26 prospective studies. Regarding colorectal cancer, no significant relationship was detected. Stratifying for ethnicity, a protective effect emerged in US subjects. Concerning colon cancer, coffee proved to exert a protective effect in men and women combined and in men alone. Stratifying for ethnicity, a significant protective effect was noted in European men only and in Asian women only. Concerning rectal cancer, no association was found. Decaffeinated coffee exhibited a protective effect against colorectal cancer in men and women combined. Studies were appraised for their quality by means of the Newcastle-Ottawa Quality Assessment Scale for Cohort studies. Only one study proved to be of low quality. Ethnicity could explain the heterogeneity of the studies. However, little is known about the relationship between the genetic make-up and the risk of colorectal cancer associated with coffee. Further research is warranted.
The Role of Mineral and Trace Element Supplementation in Exercise and Athletic Performance: A Systematic Review
Authors: Heffernan Shane Michael , Horner Katy , De Vito Giuseppe , Conway Gillian Eileen
Published: March 2019

Minerals and trace elements (MTEs) are micronutrients involved in hundreds of biological processes. Deficiency in MTEs can negatively affect athletic performance. Approximately 50% of athletes have reported consuming some form of micronutrient supplement; however, there is limited data confirming their efficacy for improving performance. The aim of this study was to systematically review the role of MTEs in exercise and athletic performance. Six electronic databases and grey literature sources (MEDLINE; EMBASE; CINAHL and SportDISCUS; Web of Science and clinicaltrials.gov) were searched, in accordance with PRISMA guidelines. Results: 17,433 articles were identified and 130 experiments from 128 studies were included. Retrieved articles included Iron (n = 29), Calcium (n = 11), Magnesium, (n = 22), Phosphate (n = 17), Zinc (n = 9), Sodium (n = 15), Boron (n = 4), Selenium (n = 5), Chromium (n = 12) and multi-mineral articles (n = 5). No relevant articles were identified for Copper, Manganese, Iodine, Nickel, Fluoride or Cobalt. Only Iron and Magnesium included articles of sufficient quality to be assigned as ‘strong’. Currently, there is little evidence to support the use of MTE supplementation to improve physiological markers of athletic performance, with the possible exception of Iron (in particular, biological situations) and Magnesium as these currently have the strongest quality evidence. Regardless, some MTEs may possess the potential to improve athletic performance, but more high quality research is required before support for these MTEs can be given. PROSPERO preregistered (CRD42018090502).
Protective Effects of CISD2 and Influence of Curcumin on CISD2 Expression in Aged Animals and Inflammatory Cell Model
Authors: Lin Chai-Ching , Chiang Tien-Huang , Sun Yu-Yo , Lin Muh-Shi
Published: March 2019

Background: Inflammation and mitochondrial dysfunction have been linked to trauma, neurodegeneration, and aging. Impairment of CISD2 expression may trigger the aforementioned pathological conditions in neural cells. We previously reported that curcumin attenuates the downregulation of CISD2 in animal models of spinal cord injury and lipopolysaccharide (LPS)-treated neuronal cells. In this study, we investigate (1) the role of CISD2 and (2) how curcumin regulates CISD2 in the aging process. Materials and methods: The serial expression of CISD2 and the efficacy of curcumin treatment were evaluated in old (104 weeks) mice and long-term cultures of neural cells (35 days in vitro, DIV). LPS-challenged neural cells (with or without siCISD2 transfection) were used to verify the role of curcumin on CISD2 underlying mitochondrial dysfunction. Results: In the brain and spinal cord of mice aged P2, 8, 25, and 104 weeks, we observed a significant decrease in CISD2 expression with age. Curcumin treatment in vivo and in vitro was shown to upregulate CISD2 expression; attenuate inflammatory response in neural cells. Moreover, curcumin treatment elevated CISD2 expression levels and prevented mitochondrial dysfunction in LPS-challenged neural cells. The beneficial effects of curcumin in either non-stressed or LPS-challenged cells that underwent siCISD2 transfection were significantly lower than in respective groups of cells that underwent scrambled siRNA-transfection. Conclusions: We hypothesize that the protective effects of curcumin treatment in reducing cellular inflammation associated trauma, degenerative, and aging processes can be partially attributed to elevated CISD2 expression. We observed a reduction in the protective effects of curcumin against injury-induced inflammation and mitochondrial dysfunction in cells where CISD2 expression was reduced by siCISD2.
Cabazitaxel-Loaded Nanocarriers for Cancer Therapy with Reduced Side Effects
Authors: Kommineni Nagavendra , Mahira Shaheen , Domb Abraham J. , Khan Wahid
Published: March 2019

Jevtana® is a micellar cabazitaxel (CBZ) solution that was approved for prostate cancer in 2010, and recently, this drug has been reported for breast cancer. The purpose of this study is to evaluate the mediated delivery of CBZ via liposomes and nanoparticles (NPs) for the treatment of breast cancer and compare these with a micellar formulation that is currently in clinical use. CBZ-loaded nanocarriers were prepared with particle sizes between 70–110 nm, and with the sustained in vitro release of CBZ for more than 28 days. Cytotoxicity studies on MCF-7 and MDA-MB-231 cells demonstrated the toxic potential of these nanocarriers. Cellular internalization revealed that NPs and liposomes have better permeability than micelles. Cell cycle analysis and apoptosis studies on MCF-7 and MDA-MB-231 cells confirmed G2/M phase arrest as well as cell death due to apoptosis and necrosis, where formulations were found to be effective compared to a micellar CBZ solution. Results from pharmacokinetic studies revealed that there is an increased circulation half-life and mean residence time for CBZ liposomes and NPs in comparison with a micellar CBZ solution. CBZ liposomes and NPs showed a reduction in hemolysis and neutropenia in comparison with a micellar CBZ solution in rats.
Root-growth Characteristics Contributing to Genotypic Variation in Nitrogen Efficiency of Bottle Gourd and Rootstock Potential for Watermelon
Authors: Ulas Abdullah , Doganci Esat , Ulas Firdes , Yetisir Halit
Published: March 2019

In this study, two hydroponic experiments were conducted in nutrient solution growth system. Experiments were conducted in growth chamber of Erciyes University, Agricultural Faculty in Kayseri, Turkey. In the first experiment, 10 local Turkish bottle gourd genotypes and two commercial watermelon cultivars were screened under 2 N doses (0.3 mM and 3.0 mM N) in RBD design with three replications for six weeks. In the second experiment, four genotypes (N-efficient: 70-07 and 07-45, N-inefficient: 35-10 and 45-07) were selected and used as rootstock for grafting with N-inefficient watermelon cultivar (Crimson Sweet) under 2 N doses. The grafted N-efficient gourd genotypes (07-45 and 70-07) significantly contributed to growth and biomass production of the N-inefficient watermelon plants as compared to non-grafted control plants and thus showed a higher rootstock potential for watermelon. The N-efficiency of some gourd genotypes was associated with vigor root growth and active root system particularly at low N conditions. These traits could be useful characters to select ‘N-efficient’ bottle gourd rootstocks for sustainable agriculture in the future.
Influences of Interface Properties on the Performance of Fiber-Reinforced Asphalt Binder
Authors: Miao Yinghao , Wang Ting , Wang Linbing
Published: March 2019

This paper presents an experimental study about the influence of interfacial properties on the performance of fiber-reinforced asphalt. In this study, four types of fiber including one fiber-reinforced plastic (FRP), two lignin fibers, and one basalt fiber are used, and also four types of asphalt: Asphalt No. 90, asphalt No. 70, one styrene-butadiene-styrene (SBS) modified asphalt, and asphalt rubber are used. The surface energy parameters of various asphalts and fibers and the shear strength of various fiber-reinforced asphalts are measured. On the basis of these measurements, the influences of surface properties of asphalt and fiber on the performance of fiber-reinforced asphalt are analyzed. The results show that the shear strength of asphalt binder can be significantly increased by adding fibers, and the reinforcement effect is closely related to the types of asphalt and fiber. It was discovered, for the same asphalt, that the basalt fiber has the best reinforcement effect, followed by the two lignin fibers, and the FRP. For the same fiber, asphalt rubber was the most reinforced, followed by the SBS modified asphalt, asphalt No. 70 and asphalt No. 90. It was also discovered, for the same asphalt, the higher the surface energy of the fiber, the better the fiber reinforcement effect. The analysis indicates a good correlation between the work of adhesion between asphalt and fiber and the effect of fiber reinforcement. The results can be used as a basis for the selection of the proper fiber-asphalt combination to improve fiber reinforcement effects.
Facile Preparation of Highly Conductive Poly(amide-imide) Composite Films beyond 1000 S m−1 through Ternary Blend Strategy
Authors: Wang Yanbin , Yu Huang , Li Yongchao , Wang Teng , Xu Tao , Chen Jinxing , Fan Zicheng , Wang Yufeng , Wang Biaobing
Published: March 2019

Highly conductive thin films with suitable mechanical performances play a significant role in modern electronic industry. Herein, a series of ternary conductive polymer composites were fabricated by incorporating carbon black (CB) into binary conductive polymer composites of poly(amide-imide) (PAI) and polyaniline (PANI) to enhance their mechanical and conductive properties simultaneously. By varying the composition of PAI/PANI/CB ternary films, the conductivity enhanced by two orders of magnitude compared with the sum of PAI/PANI and PAI/CB binary conductive polymer composites, and a high conductivity of 1160 S m−1 was achieved. The improved conductivity is mainly because much more continuous conductive networks were constructed in the ternary conductive polymer composites. With the help of the unusual morphology, the tensile strength was also enhanced by more than 80% from 21 to 38 MPa. The origin for the improved morphology was discussed for further improvement.
Removing Pb(II) Ions from Aqueous Solution by a Promising Absorbent of Tannin-Immobilized Cellulose Microspheres
Authors: Pei Ying , Xu Gaoqiang , Wu Xiao , Tang Keyong , Wang Guozhen
Published: March 2019

Tannin/cellulose microspheres (T/C) were successfully prepared via a facile homogeneous reaction in a water/oil (W/O) emulsion for removing Pb(II) ions from aqueous solution. The structure of the microspheres was characterized by scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and a zeta potential test. The effects of pH, adsorbent dosage, contact time, and temperature on adsorption ability were investigated. The results showed that T/C microspheres could combine Pb(II)ions via electrostatic attractions and physical adsorption. Adsorption kinetics could be better described by the pseudo-second-order kinetic model. The adsorption behaviors were in agreement with the Langmuir adsorption isotherm model with a fitting correlation coefficient of 0.9992. The maximum adsorption capacity was 23.75 mg/g from the Langmuir isotherm evaluation at 308K with an initial pH of 5. The results suggested that tannin/cellulose microspheres could be a low-cost and effective adsorbent for removing Pb(II) ions from aqueous solution.
Exploring Next-Generation Engineering Bioplastics: Poly(alkylene furanoate)/Poly(alkylene terephthalate) (PAF/PAT) Blends
Authors: Poulopoulou Niki , Kasmi Nejib , Siampani Maria , Terzopoulou Zoi , Bikiaris Dimitrios , Achilias Dimitris , Papageorgiou Dimitrios , Papageorgiou George
Published: March 2019

Polymers from renewable resources and especially strong engineering partially aromatic biobased polyesters are of special importance for the evolution of bioeconomy. The fabrication of polymer blends is a creative method for the production of tailor-made materials for advanced applications that are able to combine functionalities from both components. In this study, poly(alkylene furanoate)/poly(alkylene terephthalate) blends with different compositions were prepared by solution blending in a mixture of trifluoroacetic acid and chloroform. Three different types of blends were initially prepared, namely, poly(ethylene furanoate)/poly(ethylene terephthalate) (PEF/PET), poly(propylene furanoate)/poly(propylene terephthalate) (PPF/PPT), and poly(1,4-cyclohenedimethylene furanoate)/poly(1,4-cycloxehane terephthalate) (PCHDMF/PCHDMT). These blends’ miscibility characteristics were evaluated by examining the glass transition temperature of each blend. Moreover, reactive blending was utilized for the enhancement of miscibility and dynamic homogeneity and the formation of copolymers through transesterification reactions at high temperatures. PEF–PET and PPF–PPT blends formed a copolymer at relatively low reactive blending times. Finally, poly(ethylene terephthalate-co-ethylene furanoate) (PETF) random copolymers were successfully introduced as compatibilizers for the PEF/PET immiscible blends, which resulted in enhanced miscibility.
A Novel Robust Method for Solving CMB Receptor Model Based on Enhanced Sampling Monte Carlo Simulation
Authors: Hou Wen , Yang Yunlei , Wang Zheng , Hou Muzhou , Wu Qianhong , Xie Xiaoliang
Published: March 2019

The traditional effective variance weighted least squares algorithms for solving CMB (Chemical Mass Balance) models have the following drawbacks: When there is collinearity among the sources or the number of species is less than the number of sources, then some negative value of contribution will appear in the results of the source apportionment or the algorithm does not converge to calculation. In this paper, a novel robust algorithm based on enhanced sampling Monte Carlo simulation and effective variance weighted least squares (ESMC-CMB) is proposed, which overcomes the above weaknesses. In the following practical instances for source apportionment, when nine species and nine sources, with no collinearity among them, are selected, EPA-CMB8.2 (U.S. Environmental Protection Agency-CMB8.2), NKCMB1.0 (NanKai University, China-CMB1.0) and ESMC-CMB can obtain similar results. When the source raise dust is added to the source profiles, or nine sources and eight species are selected, EPA-CMB8.2 and NKCMB1.0 cannot solve the model, but the proposed ESMC-CMB algorithm can achieve satisfactory results that fully verify the robustness and effectiveness of ESMC-CMB.
“‘You Shall Love the Alien as Yourself’: Hope, Hospitality, and Love of the Stranger in the Teachings of Jesus”
Authors: Gowler David B.
Published: March 2019

The Trump administration’s controversial immigration policy has provoked significant opposition, including against a 35-day partial shutdown of the federal government over Trump’s insistence on a “wall,” but the most outrage was generated by the “zero-tolerance policy” for refugees and asylum seekers that resulted in the forced separation of thousands of children from their parents. This essay evaluates the current U.S. policy in light of the life and teachings of Jesus as portrayed in the New Testament Gospels, beginning with the flight into Egypt (Matthew 2:13–15; cf. Deuteronomy 10:19–20) but focusing primarily on Jesus’s teachings on hospitality—including the love of neighbor and the stranger—for those people with their “backs against the wall,” in the words of Howard Thurman. Key passages include the parables of the Good Samaritan (Luke 10:26–37), the Sheep and Goats (Matthew 25:31–46), and the Great Dinner (Luke 14:15–24).
A Robotic Head Stabilization Device for Medical Transport
Authors: Williams Adam , Sebastian Bijo , Ben-Tzvi Pinhas
Published: March 2019

In this paper, the design and control of a robotic device intended to stabilize the head and neck of a trauma patient during transport are presented. When transporting a patient who has suffered a traumatic head injury, the first action performed by paramedics is typically to restrain and stabilize the head and cervical spine of a patient. The proposed device would drastically reduce the time required to perform this action while also freeing a first responder to perform other possibly lifesaving actions. The applications for robotic casualty extraction are additionally explored. The design and construction are described, followed by control simulations demonstrating the improved behavior of the chosen controller paradigm, linear active disturbance rejection control (LADRC). Finally, experimental validation is presented, followed by future work and directions for the research.
Integration of Convolutional Neural Networks and Object-Based Post-Classification Refinement for Land Use and Land Cover Mapping with Optical and SAR Data
Authors: Liu Shengjie , Qi Zhixin , Li Xia , Yeh Anthony Gar-On
Published: March 2019

Object-based image analysis (OBIA) has been widely used for land use and land cover (LULC) mapping using optical and synthetic aperture radar (SAR) images because it can utilize spatial information, reduce the effect of salt and pepper, and delineate LULC boundaries. With recent advances in machine learning, convolutional neural networks (CNNs) have become state-of-the-art algorithms. However, CNNs cannot be easily integrated with OBIA because the processing unit of CNNs is a rectangular image, whereas that of OBIA is an irregular image object. To obtain object-based thematic maps, this study developed a new method that integrates object-based post-classification refinement (OBPR) and CNNs for LULC mapping using Sentinel optical and SAR data. After producing the classification map by CNN, each image object was labeled with the most frequent land cover category of its pixels. The proposed method was tested on the optical-SAR Sentinel Guangzhou dataset with 10 m spatial resolution, the optical-SAR Zhuhai-Macau local climate zones (LCZ) dataset with 100 m spatial resolution, and a hyperspectral benchmark the University of Pavia with 1.3 m spatial resolution. It outperformed OBIA support vector machine (SVM) and random forest (RF). SVM and RF could benefit more from the combined use of optical and SAR data compared with CNN, whereas spatial information learned by CNN was very effective for classification. With the ability to extract spatial features and maintain object boundaries, the proposed method considerably improved the classification accuracy of urban ground targets. It achieved overall accuracy (OA) of 95.33% for the Sentinel Guangzhou dataset, OA of 77.64% for the Zhuhai-Macau LCZ dataset, and OA of 95.70% for the University of Pavia dataset with only 10 labeled samples per class.
Urban Mapping Accuracy Enhancement in High-Rise Built-Up Areas Deployed by 3D-Orthorectification Correction from WorldView-3 and LiDAR Imageries
Authors: Rizeei Hossein Mojaddadi , Pradhan Biswajeet
Published: March 2019

Orthorectification is an important step in generating accurate land use/land cover (LULC) from satellite imagery, particularly in urban areas with high-rise buildings. Such buildings generally appear as oblique shapes on very-high-resolution (VHR) satellite images, which reflect a bigger area of coverage than the real built-up area on LULC mapping. This drawback can cause not only uncertainties in urban mapping and LULC classification, but can also result in inaccurate urban change detection. Overestimating volume or area of high-rise buildings has a negative impact on computing the exact amount of environmental heat and emission. Hence, in this study, we propose a method of orthorectfiying VHR WorldView-3 images by integrating light detection and ranging (LiDAR) data to overcome the aforementioned problems. A 3D rational polynomial coefficient (RPC) model was proposed with respect to high-accuracy ground control points collected from the LiDAR data derived from the digital surface model. Multiple probabilities for generating an orthrorectified image from WV-3 were assessed using 3D RCP model to achieve the optimal combination technique, with low vertical and horizontal errors. Ground control point (GCPs) collection is sensitive to variation in number and data collection pattern. These steps are important in orthorectification because they can cause the morbidity of a standard equation, thereby interrupting the stability of 3D RCP model by reducing the accuracy of the orthorectified image. Hence, we assessed the maximum possible scenarios of resampling and ground control point collection techniques to bridge the gap. Results show that the 3D RCP model accurately orthorectifies the VHR satellite image if 20 to 100 GCPs were collected by convenience pattern. In addition, cubic conventional resampling algorithm improved the precision and smoothness of the orthorectified image. According to the root mean square error, the proposed combination technique enhanced the vertical and horizontal accuracies of the geo-positioning process to up to 0.8 and 1.8 m, respectively. Such accuracy is considered very high in orthorectification. The proposed technique is easy to use and can be replicated for other VHR satellite and aerial photos.