bluuebunny/crossref_metadata_2025 huggingface dataset:
Antiproliferative Activity of microRNA-125a and its Molecular Targets
Authors: Russo Aniello , Potenza Nicoletta
Published: November 2018

Background:

MicroRNA-125a is present in all animals with bilateral symmetry and displays a conserved nucleotide sequence with a section of 11 bases including the seed region that is identical in all considered species. It primarily downregulates the expression of LIN28, thereby promoting cell differentiation and larval phase transitions in nematodes, mammals and insects.

Objective:

In this review, we focus on the cellular control of miR-125a expression and its antiproliferative activity.

Results:

In mammalians, microRNA-125a is present in most adult organs and tissues in which it targets proteins involved in the mitogenic response, such as membrane receptors, intracellular signal transducers, or transcription factors, with the overall effect of inhibiting cell proliferation. Tissue levels of miR-125a generally raise during differentiation but it is often downregulated in cancers, e.g. colon, cervical, gastric, ovarian, lung, and breast cancers, osteosarcoma, neuroblastoma, glioblastoma, medulloblastoma, retinoblastoma and hepatocellular carcinoma.

Conclusion:

The antiproliferative activity of miR-125a, demonstrated in many cell types, together with the notion that this miRNA is downregulated in several kinds of cancers, give a substantial support to the concept that miR-125a plays an oncosuppressive role.
How Adat Law Breaks The Cycle Of Vengeance: The Epkeret Tradition in Southern Buru
Authors: Siswanto Ari , Teslatu Leo Christy Menoha
Published: November 2018

AbstractThis study was conducted on epkeret practice as an adat institution to resolve the conflict in South Buru. Specifically, the examined problems are how epkeret contributes to resolving inter-family conflicts and how the parties perceive epkeret. This study aims to identify the potential of epkeret as a customary  dispute resolution. The research, which was mainly conducted using interview method, reveals that epkeret played an important role in preventing the cycle of violence in society. Another result obtained is that parties associated with epkeret have a positive perception of this adat institution.IntisariPenelitian ini dilakukan terhadap praktik epkeret sebagi pranata adat untuk menyelesaikan konflik di Buru Selatan. Secara lebih spesifik masalah yang diteliti adalah bagaimana kontribusi epkeret dalammenyelesaikan konflik antar-keluarga dan bagaimana pihak-pihak yang terkait mempersepsikan epkeret. Penelitian ini bertujuan mengidentifikasi potensi epkeret sebagai salah satu cara penyelesaian sengketa secara adat. Penelitian yang terutama dilakukan melalui metode wawancara ini mengungkapkan bahwa epkeret memainkan peran penting untuk mencegah siklus kekerasan di dalam masyarakat. Hasil lain yang diperoleh adalah bahwa pihak-pihak yang terkait dengan epkeret memiliki persepsi positif terhadap pranata adat ini.
Possition of Legal Service Agreement Between Advocates and Clients in Law Number 8 of 1999 on Consumer Protection
Authors: Rusdiana Sa'ida
Published: November 2018

AbstractThe legal services agreement established between the Advocate and the Client is bent in submission to the provisions set forth in Law Number 8 of 1999 on Consumer Protection. The rights and obligations arising between the Advocate and the Client under legal service agreement shall be protected by Law Number 8 of 1999. In the event of a dispute between the Client and the Advocate, the execution of the legal services agreement may use dispute resolution as stipulated in Law Number 8 of 1999 on Consumer Protection. Advocates can be regarded as business actors as referred to Law Number 8 of 1999 on Consumer Protection, in addition to performing professional duties that adhered to the professional code of ethics and legislation as mandated by Law No. 18 of 2003 on Advocates, an Advocate through a legal services agreement conducting business activities in various economic fields.IntisariPerjanjian pemberian jasa hukum yang dibuat antara Advokat dan klien tunduk pada ketentuan yang diatur dalam UU No. 8 Tahun 1999 tentang Perlindungan Konsumen. Berkaitan dengan hak dan kewajiban yang timbul antara Advokat dan klien berdasarkan perjanjian pemberian jasa hukum mendapat perlindungan dalam undang-undang tersebut. Apabila terjadi sengketa antara klien dan Advokat dalam pelaksanaan perjanjian pemberian jasa hukum dapat menggunakan payung hukum penyelesaian sengketa sebagaimana diatur dalam UU No. 8 tahun 1999 tentang Perlindungan Konsumen. Advokat dapat dikatakan sebagai pelaku usaha sebagaimana dimaksud dalam UU No. 8 tahun 1999 tentang Perlindungan Konsumen, karena selain menjalankan tugas profesi yang berpegang pada kode etik profesi dan peraturan perundang-undangan sebagaimana diamanatkan oleh UU No. 18 Tahun 2003 tentang Advokat, seorang Advokat melalui perjanjian pemberian jasa hukum menyelenggarakan kegiatan usaha dalam berbagai bidang ekonomi.
Model Mitigasi Risiko pada Lembaga Penjamin Kredit di Indonesia
Authors: Zuleha Siti
Published: November 2018

AbstractIn Indonesia there are two types of credit schemes, both credit with collateral and guarantee scheme. This study aims, describes the construction of credit-based credit agreement law and constructs a risk mitigation model.This study used a doctrinal approach that the data being studied is limited to secondary dominated by primary legal materials. Qualitative analysis method based on the theory of stage by testing the level of horizontal synchronization between the Insurance with the Guarantee Act. The results showed, credit with guarantee scheme is an expansion of the provisions of subrogation and debt coverage as stipulated in the Civil Code.IntisariDi Indonesia dikenal dua jenis skema kredit yang terdiri atas kredit dengan skema agunan (collateral)dan kredit dengan skema penjaminan. Penelitian ini bertujuan mendeskripsikan konstruksi hukumperjanjian kredit dan mengkonstruksi model mitigasi risiko pada lembaga penjamin kredit. Penelitiandilakukan dengan pendekatan doktrinal dan konsekuensianya data yang diteliti sebatas data sekunder yang didominasi oleh bahan hukum primer. Metode analisis kualitatif berbasis pada teori tangga dengan menguji taraf sinkronisasi horizontal antara Undang-Undang Perasuransian dengan Undang-Undang Penjaminan. Hasil penelitian menunjukkan, kredit dengan skema penjaminan merupakan perkembangan dari ketentuan subrogasi dan penanggungan utang menurut KUHPerdata. Namun lembaga ini memiliki kekhususunan berupa kewajiban mitigasi risiko.
Peran PTUN dan AUPB Menuju Tata Kelola Pemerintahan yang Baik (Good Governance)
Authors: Putrijanti Aju , Leonard Lapon T. , Utama Kartika Widya
Published: November 2018

Abstract The Administrative Court has an important role to supervise the government’s duty, based on principle of  good governance and regulations. Principles of good governance have been developed for some reasons. The aim of this research are to know the role of judge’s verdict and the development of principle of good governance. This research is use normative juridis method. The novelty is to strengthened the role of the judge’s verdict to build a good governance and to improve the knowledge of the importance of principles of good governance to build good governance.Intisari Pengadilan Tata Usaha Negara memiliki peran penting dalam melakukan pengawasan terhadap penyelenggaraan pemerintahan yang didasarkan pada pengujian terhadap Asas-asas Umum Pemerintahan yang Baik dan perundang-undangan. Asas-asas Umum Pemerintahan yang Baik telah mengalami perkembangan yang penting. Tujuan yang akan dicapai adalah untuk mengetahui peran putusan Hakim dan perkembangan Asas-asas Umum Pemerintahan yang Baik.Penelitian menggunakan metode yuridis normatif. Keterbaruan yaitu meningkatkan peran Pengadilan Tata Usaha Negara dan kemampuan untuk lebih memahami arti penting Asas-asas Umum Pemerintahan yang Baik menuju tata kelola yang lebih baik.
Kandungan Lemak, Koesterol dan Profile Asam-asam Lemak Daging Kerbau Yang Disuplementasi Pakan Campuran Garam Karboksilat Kering
Authors: Yurleni Yurleni , Priyantoi Rudi , Wiryawan Komang G
Published: November 2018

Penelitian bertujuan untuk mengkaji pengaruh suplementasi campuran garam karboksilat kering (CGKK) yang berasal dari minyak ikan terhadap kandungan lemak, kolesterol dan profil asam-asam lemak daging kerbau. Daging berasal dari kerbau jantan umur 1,5-2 tahun yang dipelihara secara intensif selama 2,5 bulan dengan pemberian pakan hijauan 35% dan konsentrat 65%. Suplementasi CGKK berbahan dasar minyak ikan lemuru ditambahkan sebanyak 45 g/kg konsentrat. Setelah pemeliharaan ternak dipotong. Untuk analisa daging digunakan otot longissimus dorsi. Penelitian menggunakan rancangan acak lengkap apabila ada perbedaan di uji'dengan uji lanjut Least Square MeansModels (LSMEAN). Hasil penelitian memperlihatkan bahwa suplementasi CGKK menurunkan kandungan asam-asam lemak jenuh daging kerbau dan meningkatkan kandungan asam-asam lemak tak jenuh daging kerbau. Dapat disimpulkan bahwa suplementasi CGKK meningkatkan profil asam-asam lemak tak jenuh terutama asam lemak omega-3 yaitu EPA dan DHA.

Kata kunci : kerbau, suplementasi, minyak ikan, asam-asam lemak daging.
What matters most in CEO compensation?
Authors: Beavers Randy
Published: November 2018

Components of compensation have been analysed in previous studies of corporate financial variables of interest but never together to get a sense of the complete picture of what truly matters. This paper includes variable interactions using the difference-in-differences methodology for panel regressions. Data is collected from Capital IQ, Compustat, CRSP, and ExecuComp for S&P 1500 firms from 2006 to 2013. Inside debt is negatively related to a firm’s total risk, idiosyncratic risk, and CEO turnover. Inside debt is positively related to diversification, liquidity, firm value, and return. Overconfidence is negatively related to total risk, liquidity, investment, and firm value. The CEO pay slice is positively related to total risk but negatively related to diversification, liquidity, and firm value. Interactions among these variables lead to an increase in total risk but a decrease in investment, diversification, liquidity, and firm value. Inside debt mitigates CEO risky decision making, whereas CEOs who are overconfident by their option exercise behaviour or their relative compensation to other directors creates a situation where they are encouraged to take on more risk, which, on average, is shown to harm the firm.
Przemiany własnościowe ziemi rolnej w Polsce
Authors: Jędruchniewicz Andrzej , Maśniak Jacek
Published: November 2018

Celem opracowania jest przedstawienie i ocena procesu przekształceń własnościowych ziemi rolnej w Polsce z uwzględnieniem roli, jaką odegrała polityka kształtowania polskiego modelu rolnictwa opartego na gospodarstwach rodzinnych. Zadaniem obecnie prowadzonej polityki kształtowania ustroju rolnego jest ochrona i rozwój gospodarstw rodzinnych. Od 2003 roku występują ułatwienia w dostępie do ziemi dla tych gospodarstw. W latach 1992–2016 Agencja Nieruchomości Rolnych sprzedała łącznie ponad 2,6 mln ha gruntów rolnych. Osoby fizyczne zakupiły 80,8% sprywatyzowanych gruntów rolnych, a 19,2% tego typu gruntów nabyły osoby prawne. W 2016 roku w gospodarstwach prywatnych znajdowało się 91,4% użytków rolnych ogółem, a własność publiczna stanowiła 8,6%. Struktura własnościowa ziemi rolnej w Polsce jest zróżnicowana przestrzennie. Udział prywatnej własności jest największy w województwach mazowieckim i świętokrzyskim, a najmniejszy w województwie zachodniopomorskim.
Bezpieczeństwo żywnościowe Polski na tle wybranych krajów Europy Wschodniej
Authors: Kraciuk Jakub
Published: November 2018

Celem artykułu jest ukazanie stanu bezpieczeństwa żywnościowego Polski oraz trzech krajów Europy Wschodniej sąsiadujących z naszym krajem: Białorusi, Rosji i Ukrainy. Analizowane kraje różnią się między sobą zarówno pod względem wielkości posiadanego potencjału gospodarczego, wielkości samych gospodarek, jak i poziomem ich rozwoju. Gospodarki poszczególnych krajów charakteryzuje też określona specyfika. W pierwszej części opracowania ukazano podstawy teoretyczne analizy bezpieczeństwa żywnościowego jako elementu bezpieczeństwa ekonomicznego. W następnej części dokonano charakterystyki analizowanych krajów, ukazując ich specyfikę oraz główne determinanty rozwoju. W części analitycznej przedstawiono stan bezpieczeństwa żywnościowego analizowanych krajów, wykorzystując Global Food Security Index, który został opracowany na zlecenie firmy DuPont przez Economist Intelligence Unit. Ukazano trzy składowe indeksu bezpieczeństwa żywnościowego, jakimi są: dostępność cenowa, dostęp do żywności oraz jakość i bezpieczeństwo żywności. Biorąc pod uwagę niektóre determinanty składowych bezpieczeństwa żywnościowego, podjęto próbę oceny wpływu rozwoju gospodarczego poszczególnych krajów na ich bezpieczeństwo żywnościowe.
Pozycja konkurencyjna Polski na światowym rynku zagęszczonego soku jabłkowego
Authors: Kraciński Paweł
Published: November 2018

Celem badań było określenie pozycji konkurencyjnej Polski na rynku zagęszczonego soku jabłkowego w latach 2004–2015. W badaniu wykorzystano: saldo obrotów, udział w światowym eksporcie, wskaźnik ujawnionej przewagi komparatywnej (RCA) oraz indeks relatywnej komparatywnej przewagi eksportu (XRCA). Zastosowane mierniki wykazały, że eksport z Polski był konkurencyjny. Saldo handlu zagęszczonym sokiem jabłkowym w latach 2004–2015 wzrosło. W badanym okresie zwiększył się też udział Polski w światowym eksporcie soku. W latach 2004–2015 Polska miała przeciętną i silną przewagę komparatywną w eksporcie zagęszczonego soku jabłkowego, a Chiny silną. Najsilniejszą przewagę komparatywną w latach 2013–2015 uzyskały Mołdawia i Ukraina.
Dostępność dziczyzny na polskim rynku w kontekście potrzeb konsumentów
Authors: Kwiecińska Katarzyna , Gębski Jerzy , Kosicka-Gębska Małgorzata
Published: November 2018

Dziczyzna, mimo że ma dużą wartość odżywczą, pojawia się w diecie Polaków sporadycznie. Czynnikami ograniczającymi zainteresowanie konsumentów dziczyzną są przede wszystkim ograniczona dostępność mięsa dzikich zwierząt w punktach handlowych oraz wysokie ceny mięsa i wyrobów z dziczyzny. W pracy wykorzystano wyniki badania jakościowego prowadzonego metodą CATI w grupie 450 osób spożywających dziczyznę. Wykazano, że dostępność dziczyzny (zarówno fizyczna, jak i ekonomiczna) wpływa na zainteresowanie konsumentów tego rodzaju mięsem. Na polskim rynku obserwuje się poprawę dostępności fizycznej dziczyzny. Wysokie ceny mięsa nadal stanowią istotną barierę ograniczającą zainteresowanie konsumentów dziczyzną.
Genetic polymorphism of lactic acid bacteria isolated from “Pirot ‘ironed’ sausage” from Serbia
Authors: Bogdanovic Svetlana , Jelusic Aleksandra , Beric Tanja , Nikolic Ivan , Danilovic Bojana , Stankovic Slavisa , Dimkic Ivica
Published: November 2018

The ?Pirot ?ironed? sausage? (Pis) is a traditional, dry, fermented product originating from the town of Pirot, situated in southeastern Serbia. This product is made from different types of meat (goat, sheep, beef and donkey) and spices, without additives or starter cultures. Pis is an organic, unprocessed product, without heat or smoke treatment. The aim of this study was to characterize 120 isolates of lactic acid bacteria (LAB) from Pis produced by six different brands during a two-year period using phenotypic and genetic identification. Preliminary characterization of the LAB was based on general morphology and biochemical tests. Repetitive elements such as REP, BOX and GTG5, found in the genome of these bacteria, and randomly amplified polymorphic DNA-polymerase chain reaction (RAPD PCR) sequences were used for determination of genetic polymorphism. Identification by 16S rRNA gene sequencing showed the presence of only two LAB species, Lactobacillus sakei (76%) and Leuconostoc mesenteroides (24%). However, genetic polymorphism was detected using fingerprinting methods. In comparison with other primers, the profiles obtained with GTG5 showed the highest heterogeneity for most of the tested isolates, with sequencing results additionally confirming its discriminatory power. In addition, M13 RAPD primer also produced satisfactory separation of the tested isolates.
International Mobility Based on Women Labour: Study of Changes in Socio-Economic-Cultural Family Former migrant worker Jakatawa Bulaksari In the village, District Bantarsari, Cilacap Seen From the Perspective of Islamic Economic Theory
Authors: Haris Abdul , Azizah Siti Nur
Published: November 2018

Migration is marked by international mobility occurs due to population growth which is not matched by the growth of employment. For women in the village who do not have a higher education and do not have a lot of skills, international mobility is a golden opportunity to improve their families' income. This issue is very complex but interesting to be studied.  One of the purpose of this study was to Assess the social, economic, and cultural communities Jakatawa Bulaksari in general, particularly family / former international migrant workers (TKW) before becoming migrant workers, as well as how Islam views women migrant workers, it is well known that in Islam there are three pillars used to build the economic system in the Islamic view, that is how the wealth acquired over ownership (al-milkiyah), and how the management of property ownership (tasharruf fil milkiyah), as well as how the distribution of wealth in society (tauzi'ul tsarwah bayna an- Hoodoo). These three pillars, according to the researchers, the relevant applied in the case of Indonesian Workers (TKI), especially Labor Women (TKW) which is the object of this study were associated with changes in the behavior of economic, social, and cultural. This research was conducted by survey method is the explanation of descriptive research. This research was conducted in the area of Dusun Jakatawa, Bulaksari Village, District Bantarsari, Cilacap. Based on the findings availability of jobs in the hamlet jakatawa was very limited, coupled with limited human resources in the management of agricultural land, as well as the most supportive factor is the lifestyle of a consumer society, lack of education, which raises Hamlet jakatawa option for women to work outside the country.
Use of a subcutaneous ureteral bypass device for treatment of benign ureteral obstruction in cats: 174 ureters in 134 cats (2009–2015)
Authors: Berent Allyson C. , Weisse Chick W. , Bagley Demetrius H. , Lamb Kenneth
Published: November 2018

OBJECTIVE To determine outcomes of subcutaneous ureteral bypass (SUB) device placement for treatment of benign ureteral obstruction in cats.

DESIGN Retrospective case series.

ANIMALS 134 cats with SUB devices placed in 174 obstructed ureters during 144 hospitalizations.

PROCEDURES Medical records of cats that underwent SUB device placement for treatment of benign ureteral obstruction between 2009 and 2015 were reviewed. The SUB device was placed by use of fluoroscopic and surgical methods. Signalment, history, diagnostic imaging results, postprocedural results, duration of hospitalization, complications, and short- and long-term outcomes were recorded.

RESULTS Ureteral obstructions were caused by ureterolithiasis (114/174 [65.5%]), stricture (28/174 [16.1%]), both ureterolithiasis and stricture (29/174 [16.7%]), or pyonephrosis (1/174 [0.6%]); in 2 (1.1%) cats, the cause was not recorded. Fifty-two of the 134 (39%) cats had bilateral ureteral obstruction. At admission, 127 (95%) cats were azotemic. Median serum creatinine concentrations at admission and 3 months after SUB device placement were 6.6 and 2.6 mg/dL, respectively. Median renal pelvis diameters before and after the procedure were 9.2 and 1.5 mm, respectively. Postsurgical complications included device occlusion with blood clots (14/172 [8.1%]), device leakage (6/172 [3.5%]), and kinking of the device tubing (8/174 [4.6%]). Cats survived to hospital discharge after 135 of the 144 (94%) hospital admissions. The most common long-term complication was catheter mineralization (40/165 [24.2%]), which was documented a median of 463 days after device placement. A high postoperative serum ionized calcium concentration was significantly associated with SUB device occlusion.

CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that SUB device placement may be a viable option for treatment of cats with benign ureteral obstruction.
Noncardiogenic pulmonary edema associated with ozone exposure in three kittens
Authors: Caudal Victor , Whitty Justin , Snead Elisabeth C. R. , Starrak Gregory S.
Published: November 2018

CASE DESCRIPTION Three 21-week-old sexually intact female sibling domestic shorthair cats were brought to an emergency clinic because of signs of sudden respiratory distress that were noted by the owner after the cats had been confined for approximately 10 hours in a room with an operating ozone-generating air purifier. No other potential toxicant exposures were reported.

CLINICAL FINDINGS On initial examination, the 3 cats were severely dyspneic and tachypneic. Pulmonary crackles were audible on thoracic auscultation. Thoracic radiography revealed a marked peribronchial, unstructured interstitial pulmonary pattern that coalesced to a patchy alveolar pattern, consistent with noncardiogenic pulmonary edema.

TREATMENT AND OUTCOME A diuretic (furosemide, 2 mg/kg [0.9 mg/lb], IV) and bronchodilator (terbutaline sulfate, 0.01 mg/kg [0.005 mg/lb], IM) were administered, and supplemental oxygen was provided by placing the cats in an oxygen cage at 80% oxygen saturation. By 24 hours after placement in the oxygen cage, all cats had unremarkable respiratory rates and thoracic auscultation findings. Complete resolution of the respiratory signs and radiographic pulmonary lesions was achieved within 48 to 72 hours after initial evaluation. At a recheck examination performed 3 months after initial evaluation, the cats remained free of respiratory signs, and no radiographic pulmonary lesions were detected.

CLINICAL RELEVANCE To the authors’ knowledge, this was the first reported case of pulmonary toxicosis believed to have been caused by ozone exposure in cats. Associated respiratory signs were successfully and rapidly reversed following oxygen supplementation and medical treatment.
Krisis Ekonomi Krisis Politik Dunia Dan Ihsg
Authors: Ishak Ramli Vidyarto Nugroho,
Published: November 2018

The global economic crisis of 2008-2010 had an impact on the global economic slowdown. Plus the political crisis in the countries of the Middle East region called the Arab Spring had become the center of world attention, because it also lowers economic conditions and corporate America and in other developing countries. By using daily data price of crude oil, the price of gold and exchange rates as well Rp./USD IDX Composite Index from  the year 2010 - 2012, tested the impact of crude oil prices, global gold prices on the Stock Exchange Composite Index. The result was at the time of global economic and political crisis in oil prices and the world gold price positively affects JCI opposed  to when normal conditions. When the economic crisis plus the political crisis that led to the oil price increases, the share price (CSPI) on the Stock Exchange also increased. Funds drawn investors from investing in the United States and other developing countries is invested in Indonesia so that stock prices rise along with oil prices and gold prices. While the exchange rate negatively affects Rp./USD JCI Stock Exchange, as a stronger rupiah lead JCI Stock Exchange also increased
Implementasi Kombinasi 3ic Tools Sebagai Penentu Optimasi Pengendalian Persediaan Minyak Goreng
Authors: Purnomo Hery
Published: November 2018

The purpose of this study were: 1) To analyze the brands of cooking oil that entered the class A classification using the ABC method, 2). To maximize safety stock that must be provided, and 3) determine the most Reorder Point for cooking oil products that enter in class A. This research is a descriptive research with quantitative approach. Data collection uses observation, and interview studies. In data analysis techniques, the authors do it in three stages, namely the first stage of ABC analysis to identify products in class A, B, or C; the second stage calculates safety stock for cooking oil products that enter class A; and the third stage determines the size of the Reorder Point. Then taken the conclusion according to the purpose of research. The results of this research show that from 86 types of brands and packaging of cooking oil, there are 28 packs that belong to category A, with the highest safety stock calculation is on Sugarap brand oil of Reffil 2 Liter, and Reorder Point at most on brand oil of Rosebrand Packaging Reffil 1 liter.
Entertainment with Public Displays and Personal Screens
Authors: Ventä-Olkkonen Leena , Iivari Netta , Kuutti Kari
Published: November 2018

Human-computer interaction (HCI) research has recently become more interested in studying practices. Looking beyond the novelty of technology, practice studies try to understand how technology becomes integrated into everyday life and how it shapes everyday practices in the longer time span. The contribution of this article is to demonstrate how ubiquitous computing practices develop. The article also sheds light on children’s and their families’ smart device practices in private and public settings. This paper responds to the recent call for practice studies in HCI and tries to understand technology-mediated practices of children and their families in their everyday lives. We first focused on children’s practices with a multipurpose public display through an ethnographic field study, and then broadened our focus to the children’s and families’ smart device practices through a diary study. We showed that children’s practices with a public display were surprisingly similar to their other information and communication technology (ICT) practices at home and elsewhere. In both settings, displays were used for entertainment and time-killing, as well as for babysitting and social interaction. This study indicates that technology-mediated practices do not spring up from the ground fully formed. There are several factors contributing to the practices’ emergence: the artefact itself and its affordances, the nature of the space, and the mind-set of the users. This finding has many implications for research and design, indicating that when developing technology, we should pay attention to a variety of factors that might be contributing to the emergence of practice around that technology – factors not yet fully explored by current research.
METHODOLOGICAL PRINCIPLES OF EVALUATING ECONOMIC POTENTIAL OF INDUSTRIAL ENTERPRISE SUSTAINABLE DEVELOPMENT
Authors: Yemelyanov Olexandr Yuriiovych , Kurylо Oksana Bogdanovna , Petrushka Tetiana Oleksiivna
Published: November 2018

Urgency of the research is determined by the urgent need to increase the competitiveness and improve the financial condition of Ukrainian industrial enterprises on the basis of their transition to sustainable development.
Target setting. The implementation of measures for building a sustainable model of enterprise economic development requires a preliminary evaluation of the economic potential of enterprise sustainable development.
Actual scientific researches and issues analysis. The study of the principles of enterprise economic development is a key issue for many scientists. In particular, the conditions and mechanisms of building innovative model of economic development of Ukraine were developed, the methods of evaluating economic development potential of enterprises were presented, and the peculiarities of implementation of sustainability measures were analyzed.
Uninvestigated parts of general matters defining. The issue of quantitative evaluation of enterprise sustainability development potential remains unresolved.
The research objective. The aim of this article is to develop methodological principles for evaluating economic potential of sustainable development of industrial enterprises as a prerequisite for developing scientifically sound sustainability policy.
The statement of basic materials. The article presents the typology of enterprise sustainable development kinds. The criteria for the development are suggested. The effect of sustainability measures on the level of economic development of enterprises is analyzed. The method of economic potential evaluation of sustainable development of industrial enterprises using the system of evaluation indicators is presented.
Conclusions. The employment of the developed methodological approaches to evaluation of the economic potential of industrial enterprise sustainable development will enhance the efficiency of management decisions on establishing sustainable development programmes in the enterprises.
START-UP: SEARCH OF WAYS OF INVESTMENT SUPPORT FOR DEVELOPMENT OF SMALL BUSINESS
Authors: Byba Volodymyr Vasylovych , Vasiuta Viktoriia Borysivna , Miniailenko Inna Valentynivna
Published: November 2018

Urgency of the research. The article is devoted to research of ways of investment support of small business as a driving force of the economy. The generalization of foreign experience has allowed to determine the main condition for the development of small business start-ups. Today, the implementation of startups is the future of an efficient economy.
Target setting. Successfully designed and developed technique for evaluating the value of startups are part of the financial success of their implementation.
Actual scientific researches and issues analysis. Famous foreign scientists as G. Kawasaki, M. Nijier, D. Wumek, J. Lyker, B. Feld and others have made significant contributions to the development of startups, their emergence in markets, the study of economic instruments for increasing profitability and attracting investments.
Uninvestigated parts of general matters defining. At the same time, insufficient scientific works highlight the economic indicators of the effectiveness of the introduction of start-ups. Need additional research on the development of tools for improving the financial success of new projects of small enterprises.
The research objective. Defining a system of economic indicators for the effective development of startups and testing tools for the costs of their identification and monitoring.
The statement of basic materials. The methods of estimating the projects of the launch of pre-investment investments were analyzed. The calculation of the investment value of the company and the method of returning the venture capital through the final cost is tested. The optimal way of evaluating the Startup Start Cost Index is determined on the basis of the average Startup Cost and Segment Cost Index.
In order to take into account the costs of implementing the startup it is expedient to use the theory of solving inventive tasks "Lean production", which will allow to build an effective system of management of aggregate expenses and further control over their dynamics.
Conclusions. The result of the introduction of effective startups is the intensification of investment and innovation activities, the development of small business, solving social problems.
SANATORIUM AND HEALTH RESORTS IN UKRAINE: VIEW CHARACTERISTIC, REGIONAL SPECIFICITY AND DYNAMICS OF DEVELOPMENT
Authors: Karyy Oleh Igorovych , Нalkiv Lіubov Ivanivna , Halaz Lina Volodymyrivna
Published: November 2018

Urgency of the research. The problem of preserving human health in modern conditions is of growing importance in an environment. The main role of solving this problem is played by institutions of sanatorium-resort type. Proceeding from this, there is a need for expanding the spectrum of theoretical-applied researches of the indicated subjects of management.
Target setting. To attract the attention of society and academics to the specifics of the sanatorium and resort institutions activities will focus a glance to the problems that can reduce the loss of human capital.
Actual scientific researches and issues analysis. The significant contribution to the research of this topic was done by such respected scholars as A. Mazaraki, N. Vedmid, V. Gumenyuk, and others.
Uninvestigated parts of general matters defining. On the background of a significant circle thorough scientific researches of the domestic sanatorium and resort area, the need for new research remains high, because, first of all, certain aspects of the regional dimension fell out of the scientists sigh, secondly, it requires deepening the theoretical basis for structuring the subjects of production sanatorium, health and wellness services.
The research objective. Based on the purpose of the work, the following tasks are defined: generalize the typology of sanatorium, health and wellness services; to conduct an integrated assessment of the activities of sanatorium and health resorts establishments in the regions of Ukraine; to study the dynamics of sanatorium and health resorts of Ukraine.
The statement of basic materials. The article generalizes approaches to the selection of sanatorium and resort activity types. A system of metrics has been formed and used for integrated assessment of their activity. The dynamics of sanatorium and health resorts establishments network is analyzed for the period 2001-2016.
Conclusions. Sanatorium and health resorts are important element to ensure the preservation and development of human potential. The public institutions approaches to the typology of these institutions may vary. Regional markets for sanatorium and resort services develop disproportionately, and the network of institutions is decreasing.
APPROACH TO ANALYTICAL SUPPORT FOR ASSESSING THE SECURITY OF HUMAN DEVELOPMENT
Authors: Nazarova Galina Valentynivna , Nazarov Nikita Kostiantynovych , Demianenko Alina Anatoliivna
Published: November 2018

Urgency of the research. In the conditions of instability and uncertainty of the processes that affect people's security and human development, the importance of preventing and avoiding negative environmental impacts highlighted the issue of assessing the human development security.
Target setting. The formation of human development security is carried out under the influence of various factors, which are difficult to prevent in a timely manner, but with the help of a comprehensive assessment of this process it becomes possible to develop of a mechanism for anticipating and preventing the losses of human development.
Actual scientific researches and issues analysis. The issue of developing methodological support for measuring human development and human security was considered by foreign scientists: Mahbub ul Haq and A. Sen, M. Peleah and A. Ivanov, David A. Hastings and others; and Ukrainian scientists: O. Vlasyuk, T. Ivashchenko, E. Libanova, O. Makarova and O. Gladun and others.
Uninvestigated parts of general matters defining. Based on the work of foreign and domestic scientists, the issue of a comprehensive assessment of the human security development process has not been investigated.
The research objective. To develop a sequence for the development of a scientific and methodological approach to analytical support for the assessment of human development security.
The statement of basic materials. In the article a critical analysis of existing methodological approaches to the assessment of human development and human security was systematized and conducted. The methodical approach to the analytical support for assessing the security of human development, which will provide the most complete measurement of the process, is substantiated.
Conclusions. Taking into account the advantages and disadvantages of methodological approaches to the assessing of human development and human security has allowed to form a sequence of development of a scientific and methodological approach to analytical support for assessing the security of human development.
FORMATION AND DEVELOPMENT OF ORGANIC PRODUCTION OF THE UKRAINIAN MARKET
Authors: Kolomytseva Olena Vitaliivna , Vasilchenko Lidiya Serhiivna , Pepchuk Serhii Mykolaiovych
Published: November 2018

Urgency of the research. The organic production market over the past decades is extremely promising as demand for real food has increased. The urgency is caused by the problem of providing the population with ecologically safe products and the need for operation of the organic production market.
Target setting. The intensive technological development and the environment pollution endanger the further human development and lead to the necessity of reproducing approach usage for solving environmental problems. Partial reduction of environmental pollution is possible through organic production.
Actual scientific researches and issues analysis. The following scientists have made a great contribution to the problems concerned the development of organic production market in Ukraine: Chychkalo-Kondratska I. B., Cuzmenko O. B., Tovmashevska, О. A. Pearson D. and others
Uninvestigated parts of general matters defining. This problem above has already been researched in many papers. But in spite of this, the possibilities of adapting foreign experience to create a competitive organic production market in Ukraine are understudied.
The research objective is to determine the peculiarities of the formation and prospects for the development of organic production market, as well as to make a comparative analysis of organic market trends in Ukraine and other countries, to highlight the experience of state support of this market in these countries.
The statement of basic materials. The article contains the factors that describe priority of organic production development in Ukraine and the reasons that restrain it. The suggestions on effective development of organic production in Ukraine under conditions of economic changes are presented.
Conclusions. For the effective development of organic production in Ukraine a set of measures should be introduced, including legal, regulatory, financial, advisory support and improvement of control tools.
TOPICAL CONCEPTIONS OF THE DEVELOPMENT OF INFORMATION SOCIETY UNDER CONDITIONS OF NBIC-CONVERGENCE
Authors: Chubukova Olga Yuriivna , Rallie Nataliia Viktorivna , Zimbalevska Yuliia Viktorivna
Published: November 2018

Urgency of the research. The need for studying the problems and current trends in the field of integration of scientific achievements of the present in the context of its influence on the social paradigm is caused by the requirements and challenges of the next stage of civilization development - the information society.
Target setting. It is expedient to update the directions of the development of the information society and formulate its main concepts on the basis of the analysis of the achievements of world science.
Actual scientific researches and issues analysis. The scientific works of such scholars as I. Rodzin, S. Titarenko, M. Anissimov, J. Schummer, K. Borner, M. Rocco, V. Bainbridge and others are devoted to questions of the actual technological, social and economic aspects of the information society.
Uninvestigated parts of general matters defining. The scientists have not yet sufficiently developed the issues of developing and implementing the achievements of the newest world-building technologies in their synergy and interacting within the framework of the NBIC-convergence.
The research objective. The article aims to analyze and develop proposals for the actual concepts of building an information society in the context of NBIC-convergence.
The statement of basic materials. The article defines the main components of NBIC-convergence and the results of their interdependent development, which form the latest technological basis of the information society. It is substantiated the necessity of development of cognitive technologies in the socio-economic sphere in their synergy with information technologies. It is offered hypothetical directions of development of society in the post-informational era.
Conclusions. NBIC-convergence as the natural process of science towards the synergistic interaction and interdisciplinary scientific approaches creates the foundation for the transition to a new state of human capabilities through radical technological transformation.
SYNERGETIC INTERACTION OF THE BIOECONOMICS PRINCIPLES IN THE GLOBAL ECONOMIC SYSTEM STRUCTURE
Authors: Vdovichen Anatolii Anatoliiovych , Vdovichena Olga Hennadiivna
Published: November 2018

Urgency of the research is to take into account the principles of bioeconomy in integrating economic systems into the world economy with the focus on providing conditions for minimizing various risks.
Target setting. Determination of the bioeconomy principles in synergistic interaction, which will reveal their socio-economic beneficial effect for the development of the world economy.
Actual scientific researches and issues analysis. Solving the issues of economy formation and development both in the world and in Ukraine.
Uninvestigated parts of general matters defining. Studying synergistic interaction new forms and methods of bioeconomic processes and their integration into the global economic system.
The research objective. Studying the synergistic interaction basic principles of bioeconomy from the point of effective socio-economic development.
The statement of basic materials. Bioeconomy is considered as an economic mechanism for the biotechnology implementation. The value of this approach is to take into account the triple combination of the sustainable development principles: economic, social, biological, based on four fundamental foundations: gene technology and industry engineering; resource-restoration production; research-scientific integration; practical bioclast orientation.
Conclusions. The bioeconomy basic principles fulfillment will make it possible to reorient the global management system to a new high-quality level, on which basis strategy of socially-oriented and safe development of the economic system will be based.
CROWDSOURCING AS A PART OF COMPANY’S INTELLECTUAL CAPITAL
Authors: Dzhedzhula Viacheslav Vasylovych , Yepifanova Iryna Yuriyivna
Published: November 2018

Urgency of the research. In modern conditions of management it is important for enterprises to form of the necessary amount of intellectual capital.
Target setting. Most domestic enterprises do not pay enough attention to this issue. That is why it is very important to determine the directions of its growth.
Actual scientific researches and issues analysis. The issue of intellectual capital management, its influence on innovation activity has been considered in the works of L. Antonyuk, S. V. Zakharinko, A. Kendiukhov, G. R. Natroshvili, V. Tsipurindy, L. Fedulova.
The issues of crowdsourcing were considered in the works of Paul Whitla, Howe J., Maistrenko O. V., Khymych I.
Uninvestigated parts of general matters defining. The issue of evaluating the intellectual component of energy saving policy, in particular, with the help of the apparatus of hybrid neural networks, remains poorly developed.
The research objective. It is important to assess the factors influencing the intellectual capital of industrial enterprises, to determine the possibility of increasing the efficiency of using intellectual capital with the help of crowdsourcing.
The statement of basic materials. The components of intellectual capital have been investigated. The indexes of knowledge economy of Ukraine and developed countries have analyzed. The essence of crowdsourcing and its components have been defined; the modern examples of its application in the world and in Ukraine have been researched. It has been determined that this tool is used mainly in the social sphere in Ukraine. The importance of its use in raising the intellectual component of innovation activity of domestic enterprises has been substantiated.
Conclusions. It has been established that active involvement of students in the activity of the enterprise can be very promising for domestic enterprises.
Recommendations for industrial enterprises to increase attention to crowdsourcing as an important source of intellectual capital growth were developed.
Structural Basis for Selectivity in Flavin-Dependent Monooxygenase-Catalyzed Oxidative Dearomatization
Authors: Benítez Attabey Rodríguez , Tweedy Sara , Dockrey Summer A. Baker , Lukowski April L. , Wymore Troy , Khare Dheeraj , Brooks III Charles L. , Smith Janet L. , Narayan Alison
Published: November 2018

Herein, we disclose the structural basis for substrate binding in TropB, which performs a synthetically challenging asymmetric oxidative dearomatization reaction with exquisite site- and stereoselectivity across a range of substrates, providing a foundation for future protein engineering and reaction development efforts. Our hypothesis for substrate binding is informed by the first crystal structure of TropB and molecular dynamics simulations with the corresponding computational TropB model and is supported by experimental data.
Нефтяной кризис и доступ к рынкам капитала
Authors: Лукьяненко Карина Сергеевна
Published: November 2018

Целью данной статьи является анализ влияния низких цен на нефть на поведение кредиторов и прогнозировании их рыночного поведения в условиях нестабильности. Метод и методология проведения работы. Исследование, проведенной в данной статье основывается на трудах как отечественных ученых, так и иностранных авторов. В работе также используются данные статистических международных агентств. К статье использована общенаучная методология с применением системного подхода при рассмотрении ряда проблем, рассмотренных в статье. Результаты. Когда в январе 2016 года был отменен запрет на экспорт сырой нефти в США, многие в целом рассматривали его как положительное решение для промышленности и свободной торговли, но не было уверенности в ее влиянии на мировой рынок в целом. 2017 год стал годом, когда Соединенные Штаты подтвердили свой растущий статус экспортера энергии. Растущее место в качестве экспортера нефти и газа и недорогого поставщика может кардинально изменить позиции США на глобальном энергетическом ландшафте. Оптимистичные данные по ВВП США в третьем квартале помогли подтолкнуть нефть к недавним максимумам. Кроме того, октябрьский отчет о заработной плате показал, что внутренний рынок труда отскочил от последствий ураганов. Позитивная оценка заказов на товары длительного пользования в США также указывает на укрепление экономики. Наконец, сильные отчеты о доходах от корпоративных гигантов, которые помогли поддержать высокую стоимость, повысили настроения. В данной статье проанализировано влияние мирового нефтяного кризиса на производственно-добывающие компании США. В статье приведены статистические данные по банкротству, по динамике цен на нефть. В работе рассмотрены изменения при хеджировании активов нефтегазовых компаний. Область применения результатов. Результаты приведенных данных могут быть широко использованы как при построении прогнозов поведения нефтяной отрасли США так и финансового мирового рынка, связанного с деятельность нефтегазовых компаний. Выводы. В условиях, когда американская экономика остается на прочном фундаменте, результирующий рост спроса является хорошим предзнаменованием для цен на нефть. Курс на повышение цен на нефть уже намечен, неопределенным остается предел новых ценовых нефтяных максимумов.