bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving Screening for Social Determinants of Health in an Outpatient Complex Care Clinic
Authors: Randolph Arielle , Butts Breann , White Cynthia , Auberger Amelia , Bohache Meredith , Goddard-Roaden Carrie , Beck Andrew F. , Brinkman William B. , Thomson Joanna
Published: September 2024

BACKGROUND

Families of children with medical complexity (CMC) may face challenges related to Social Determinants of Health (SDoH). Although standardized SDoH screening has been implemented in numerous medical settings, there has been limited study of screening among CMC. Our global aim is to improve access to institutional and community resources for families of CMC with identified needs. Here, we aimed to establish SDoH screening for families in our outpatient Complex Care Center and attain a screening rate of 80%.

METHODS

A multidisciplinary team in our clinic used quality improvement methods to implement and study an expanded SDoH screen, which included 3 questions specific to the needs of CMC (ie, emergency planning, social support, and medical equipment concerns). Interventions, informed and refined by 5 key drivers, were tested over a 12-month period. A statistical process control chart tracked key outcome and process measures over time.

RESULTS

SDoH screening sustained a mean of 80% after implementation during the study period. Incorporating registration staff in screen distribution was our most impactful intervention. At least 1 SDoH concern was identified on 56% of screens; concerns specific to CMC and mental health were most frequently reported. A total of 309 responses to positive screens were reported in total.

CONCLUSIONS

Successful implementation of an expanded, tailored SDoH screen revealed a multitude of social needs specific to families of CMC that otherwise may not have been recognized. Our team continues to develop and distribute resources to address identified needs.
RIQUEZA Y ABUNDANCIA DE MARIPOSAS DIURNAS (INSECTA: LEPIDOPTERA) EN ÁREAS PERTURBADAS DE LOS ANDES CENTRALES DE COLOMBIA
Authors: Gómez Salazar Juan Camilo , Ordoñez-Díaz Martha Melizza , Guevara Giovany , Murillo-Montoya Sergio Adrián
Published: September 2024

En este estudio, se evaluó la abundancia y riqueza de especies de mariposas diurnas en tres coberturas vegetales de un área ubicada en los Andes centrales de Colombia. Se realizaron tres muestreos en cada tipo de cobertura, entre diciembre de 2021 y enero-febrero de 2022, utilizando dos métodos de captura: jama entomológica y trampa Van Someren-Rydon, esta última cebada con banano en descomposición y camarón licuado. Se registraron 725 especímenes distribuidos en seis familias, 21 subfamilias y 179 especies. Los resultados evidenciaron la presencia de especies indicadoras de áreas perturbadas, como Anarthia amathea amathea, Heliconius clysonymus clysonymus, Phoebis philea philea, Pyrisitia venusta aequatorialis, Spicauda simplicius, Hermeuptychia hermes, Heliconius melpomene, Adelpha alala alala y Oxeoschistus simplex simplex. Se reportaron especies de la subfamilia Heliconiinae endémicas de la cordillera central, como Heliconius cydno cydnides y Heliconius erato chestertonii. Se observó una elevada riqueza y abundancia de mariposas presentes en esta región subandina. Se recomienda realizar estudios en otra época del año (verano), para garantizar una representatividad mayor de las especies de mariposas allí existentes.
The impact of fenugreek, black cumin, and garlic on dough rheology, bread quality, antimicrobial activity, and microstructural analysis using a scanning electron microscope
Authors: Zerlasht Mehwish , Javaria Sadaf , Quddoos Muhammad Yousaf , Arshad Rizwan , Yaqub Shazia , Zubair Khalid Muhammad , Sana Mahmood Sayyad , Rafique Ayesha , Umar Farooq Muhammad , Alsulami Tawfiq , Akram Saima , Rafique Hamad
Published: September 2024

Fenugreek, black cumin, and garlic are herbs that are rich sources of antimicrobial and nutritional bioactive compounds. This study investigated the influence of herbs on the rheological characteristics of dough and the quality parameters of bread. The antimicrobial activity of the herbs was determined against the pathogens at 50 and 100 mg/mL concentrations. Maximum zone inhibition was measured for fenugreek against Salmonella typhimurium (16.5 mm) at 100 mg/mL concentration. Dough development time and departure time increased with the increase in concentration of the herbs. Farinograph quality number (FQN), mixing tolerance index, and stability varied significantly with the treatments such as physio-chemical, structural, textural, and sensory parameters at herbs concentration 0.25, 0.5, and 0.75%, respectively. Ash, fiber, fat, protein content, firmness, and total phenolic content were increased with treatments. However, a decrease in moisture content and total plate count was observed due to the addition of herbs. The microstructure revealed that the addition of fenugreek significantly improves the bread structure. The sensory profile of bread was not affected with the addition of herbs at a concentration of 0.50%.
Ocena długoterminowej efektywności zatrudnieniowej dofinansowań na podjęcie
działalności gospodarczej na przykładzie beneficjentów z terenu województwa
podkarpackiego w latach 2015-2022
Authors: Bednarz Bartłomiej
Published: September 2024

Cel: Celem opracowania jest ocena długoterminowej efektywności zatrudnieniowej
dofinansowań na podjęcie działalności gospodarczej finansowanych z Funduszu Pracy i
przeznaczonych dla osób bezrobotnych na przykładzie beneficjentów z terenu województwa
podkarpackiego w latach 2015-2022. Metodyka: W badaniu dokonano systematycznego
przeglądu literatury, wykorzystując bogaty dorobek krajowej i zagranicznej literatury
przedmiotu – wybierając tę o wysokiej jakości, oryginalności oraz aktualności.
Posługując się metodą desk research, wykorzystano dane empiryczne udostępniane w
Centralnej Ewidencji i Informacji o Działalności Gospodarczej (obejmujące lata
2015-2024) oraz w Systemie Udostępniania Danych o Pomocy Publicznej (z okresu
2015-2022). Wyniki: W wyniku przeprowadzonej analizy uzyskano informacje o jej
efektywności zatrudnieniowej po trzech, czterech, pięciu, sześciu, a nawet siedmiu
latach od momentu zakończenia udziału w niej osób bezrobotnych. Ustalono, że
samozatrudnienie jako forma aktywizacji zawodowej w długim okresie nie jest tak
efektywna, jak sugerowałyby dane przedstawiane przez Ministerstwo Rodziny, Pracy i
Polityki Społecznej. Implikacje i rekomendacje: Na podstawie opracowanych wyników
uzasadniona wydaje się korekta zasad dotyczących przyznawania dofinansowań na podjęcie
działalności gospodarczej dla osób bezrobotnych, np. w zakresie długości wymaganego
czasu prowadzenia przedsiębiorstwa. Istnieje potrzeba kontynuowania badań w celu
poszerzenia badanej grupy o przedsiębiorstwa w pozostałych województwach powstałe w
wyniku udzielonej pomocy, analizy innych niż Fundusz Pracy źródeł finansowania, a także
struktury beneficjentów i informacji o efektywności zatrudnieniowej dofinansowań w
poszczególnych sektorach gospodarki. Oryginalność/wartość: Powstałe opracowanie wypełnia
lukę w literaturze w zakresie braku informacji o poziomie efektywności zatrudnieniowej
beneficjentów badanej formy pomocy w okresie dłuższym niż 24 miesiące.
Ocena sytuacji finansowej polskich jednostek samorządu terytorialnego w 2022 roku z
wykorzystaniem metod taksonometrycznych
Authors: Zientarski Kamil
Published: September 2024

Cel: Celem artykułu jest zaprezentowanie sytuacji finansowej samorządów
grupowanych według poszczególnych szczebli oraz relacji zachodzących pomiędzy nimi, a
także propagowanie wykorzystywania w tym celu metod taksonometrycznych. Przegląd
literatury pozwala stwierdzić, iż problematyka ta nie jest podejmowana w pracach
naukowych. Metodyka: Do analizy sytuacji finansowej JST użyto metod taksonometrycznych.
Obliczenia zostały wykonane w dwóch kategoriach, co wynika z występowania w polskim
podziale administracyjnym miast na prawach powiatu. Zaproponowano również analizę
korelacji liniowej Pearsona jako sposób wyboru optymalnej metody taksonometrycznej.
Wyniki: Potwierdzono hipotezę o zróżnicowaniu sytuacji finansowej samorządów danych
szczebli. Prawdziwa okazała się także powszechna opinia, iż najgorszą sytuacją finansową
charakteryzują się powiaty. Przyczynami tego stanu są nadmiar nałożonych na nie zadań
oraz niewielkie możliwości wpływania na własne strumienie dochodowe. Potwierdzono
również, iż miasta na prawach powiatu mają lepszą sytuację finansową niż gminy i
powiaty, co jest pochodną ich bogactwa endogenicznego. Implikacje i rekomendacje:
Rekomenduje się przeprowadzanie analogicznych badań w zakresie przekroju regionalnego
różnych szczebli JST względem siebie. Oryginalność/wartość: W pracy udowodniono
empirycznie, iż nawet przy bardzo małych liczbach obiektów można stosować metody
taksonometryczne oraz wybierać optymalną z nich. Zaproponowano także autorskie
przekształcenie danych w procedurze normalizacyjnej.
Virtue Ethics and Organizational Culture Management in Humanitarian Assistance
Authors: Płachciak Adam
Published: September 2024

Aim: The aim of the article is to investigate the validity of virtue ethics to
humanitarian organizational culture management. Methodology: The method applied is
basically focused on the analyses of the relevant literature. Results: The results of
the paper show that a humanitarian virtuous agency conducted by innate moral qualities
can employ standards that are far beyond formal code duties or effectiveness.
Implications and recommendations: Virtue ethics, by stressing the importance of
motivational aspects, has unquestionable implications in analyses around humanitarian
organizational culture management. Originality/value: Motivational aspects become
fundamental for relief workers, especially in situations where normality means lack of
normality.
Free vibration and transient response of initially compressed CNT-reinforced composite plates
Authors: Thinh Nguyen Van , Anh Nguyen Dong , Trang Le Thi Nhu , Tung Hoang Van
Published: September 2024

This paper investigates the linear free vibration and nonlinear transient response of carbon nanotube (CNT)-reinforced composite plates subjected to pre-existent compressive load in thermal environments. CNTs are reinforced into matrix according to uniform and functionally graded distributions. The properties of constitutive materials are assumed to be temperature-dependent while the effective properties of nanocomposite are determined using an extended rule of mixture. Governing equations are established within the framework of classical plate theory incorporating von Kármán nonlinearity and initial geometrical imperfection. Analytical solutions of deflection and stress function are assumed to satisfy simply supported boundary conditions, and Galerkin method is applied to obtain a time differential equation including both quadratic and cubic nonlinear terms. Fourth-order Runge–Kutta numerical integration scheme is employed to determine dynamical deflection-time response of nanocomposite plates. Numerical analyses are presented to consider the influences of CNT volume fraction, CNT distribution, initial compressive load, geometrical imperfection, elevated temperature and plate geometry on the natural frequencies and nonlinear dynamical response of nanocomposite plates. The study reveals that the natural frequency and dynamical deflection are strongly decreased and increased when initial compressive load is increased, respectively. Numerical results also find that the natural frequencies are enhanced and dynamical deflection is dropped as a result of increase in volume percentage of CNTs, respectively.
Comparative analysis of TREC and KREC concentration levels in children at medical and biological risk (CHD – frequently ill children, children who have been operated for congenital heart defect with combined thymectomy, children – without it) and those conditionally healthy
Authors: Rovda Yu. I. , Vedernikova A. V. , Shabaldin A. V. , Filipenko M. L. , Sinitskaya A. A. , Khalivopulo I. K. , Grishacheva E. O. , Otstavnov G. A. , Shkitin Ya. V. , Minyailova N. N. , Khobotkova T. S. , Dadonov V. V.
Published: September 2024

The purpose of the study was to compare and analyze the levels of KREC (kappa-deleting recombination excision circle) and TREC (T cell receptor excision circle) levels, which indirectly reflect impaired maturation of T and/or B lymphocytes, in children of the medical and biological risk group and the comparison group (patients considered relatively healthy, relative to the population).

The medical and biological risk groups were:

1) 15 children with operated congenital heart defects with combined thymectomy and 9 without it; the average age is 5 months ±4 months and 7 months ±3 months, respectively; and

2) 27 children with relatively frequent morbidity of the respiratory tract (acute respiratory viral infection more than 8 times a year) aged 1.6±1.4 months, among whom the proportion attending a preschool institution is 20 people (74%).

The comparison groups were:

1) 16 relatively healthy children (health group 1) aged 1.7±1.6 years, among whom the proportion of those attending a preschool institution was 13 people (81%); and

2) 48 apparently healthy newborn children, whose average age was 15±12 days.

Quantitative determination of TREC and KREC was carried out using a multiplex test system developed at the Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences (Novosibirsk). The average concentrations of TREC and KREC were determined in apparently healthy newborns. Children with a high incidence of infectious respiratory morbidity (more than 8 cases of acute respiratory viral infection per year) had a significantly higher risk of developing disorders of both T cell and B cell immunity, compared with the healthy population. Children who underwent total thymectomy during surgical treatment of congenital heart defects had a higher risk of developing immunodeficiency conditions, affecting predominantly T cell immunity, in comparison with the group of children operated on with preservation of the thymus gland.
Expression of checkpoint molecules by regulatory T cells in multiple myeloma
Authors: Ostanin A. A. , Batorova D. S. , Sizikova S. A. , Krukovich A. B.
Published: September 2024

In multiple myeloma (MM), the content of T lymphocytes expressing “checkpoint” molecules PD-1, TIM-3, LAG-3, etc. is increased. Regulatory T cells (Treg) can suppress antitumor immune response and play a sufficient role in MM pathogenesis. Like effector T lymphocytes, some Tregs express checkpoint receptors PD-1, TIM-3, etc., however, the biological meaning of such expression, as well as the consequences of blockade of these receptors, are not clear. The significance of type I regulatory T cells (Tr1), which produce the immunosuppressive cytokine interleukin-10, in MM also remains unexplored. The purpose of this work was to study the content of PD-1- and TIM-3-expressing Tregs and Tr1 in patients with MM. The study included 36 patients with MM and 24 matched healthy donors. The content of CD4+CD25hiCD127-FoxP3+Tregs and IL-10-producing CD4+IL-10+Tr1 populations expressing PD-1 and TIM-3 was assessed in peripheral blood (PB) and bone marrow (BM) by flow cytometry. The relative content of circulating CD4+CD25hiCD127-FoxP3+Tregs and IL-10-producing CD4+IL-10+Tr1 was significantly higher in MM patients compared to healthy donors. A higher relative content of IL-10-producing T lymphocytes was noted compared to Treg. The relative content of Tregs and Tr1 in BM samples did not differ significantly from PB values. The proportion of Tregs expressing PD-1 and TIM-3 in patients with MM did not differ significantly from the values in healthy donors. The content of PD-1- and TIM-3-positive CD4+IL-10+T cells was significantly higher in PB samples from MM patients compared to donors.

IL-10-producing CD4+T cells constitute a significant proportion of T lymphocytes in the PB and BM of patients with MM and may play an important role in the pathogenesis of MM. Their content exceeds that of CD4+CD25hiCD127-FoxP3+Treg. A relatively small number of Tregs express the checkpoint receptors PD-1 and TIM-3, no different from donors. The proportion of PD-1-/TIM-3-positive cells is ~20% of CD4+IL-10+T cells and significantly exceeds the values of healthy individuals.
Features of the expression of genes of antimicrobial peptides and the microbiome at the level of the mucous membrane of the upper respiratory tract during aging
Authors: Burmakina V. V. , Vartanova N. O. , Khoreva M. V. , Gorodishchenskaya S. V. , Avagyan A. S. , Svitich O. A.
Published: September 2024

Today, the proportion of elderly and senile people is steadily growing throughout the world. The most important factors in the first line of immune defense of the mucous membranes of the upper respiratory tract are β-defensins, which are a group of secretory proteins with antimicrobial activity. The aim of this study was to study the expression of genes for antimicrobial peptides β-defensins and the composition of the microbiome of the mucous membranes of the upper respiratory tract in elderly people and long-livers with various aging phenotypes.

The main study group included 67 centenarians and 49 elderly people, who were further divided into two subgroups depending on the course of aging (pathological and successful aging). Nucleic acids were isolated from nasopharyngeal scrapings and the expression levels of the DEFB1 and DEFB4 genes were determined using real-time polymerase chain reaction. The composition of the microbiota in nasopharyngeal swabs was determined by MALDI-TOF mass spectrometry.

In analyzing the expression of the DEFB1 gene in elderly people and centenarians with successful and pathological aging phenotypes, no difference was revealed between the groups. Expression of the DEFB4 gene was increased in centenarians with pathological aging compared to centenarians with successful aging and in the elderly group. Excessive production of antimicrobial peptides is dual in nature; on the one hand, they provide the first line of defense against microorganisms, and on the other, they are cytotoxic to their own cells. An increase in the expression of the DEFB4 gene during aging may be due to an increase in the number of pathogen-associated molecular patterns, which can be one’s own microbiota and/or components of microbial metabolism. Analysis of the microbiota composition showed an increase in biodiversity in individuals with a successful aging phenotype compared to a pathological phenotype. Particular attention is paid to Staphylococcus spp., the species composition of which depends on the aging phenotype. In the pathological aging group, the frequency of St. aureus colonization is significantly higher than in the successful aging group.

Thus, overexpression of the DEFB4 gene and changes in the composition of the microbiota of the mucous membranes of the upper respiratory tract may be one of the mechanisms explaining the increased susceptibility to infections in various aging phenotypes.
Impaired tolerance of monocyte-macrophages to lipopolysaccharide in patients with coronary atherosclerosis
Authors: Chegodaev E. S. , Nikiforov N. G. , Popov M. A. , Shumakov D. V. , Zybin D. I. , Orekhov A. N.
Published: September 2024

Atherosclerosis is a chronic disease in which lipids, cells and various proteins accumulate in the walls of the arteries, forming atherosclerotic plaques. The growth of plaques leads narrowing of the lumen of the blood vessels. Atherosclerosis is accompanied by local inflammation, while the number of hematogenous macrophages are derived from monocytes increases in the vascular wall. The reasons why the inflammatory reaction cannot be completed and becomes chronic are not clear. To resolve inflammation and protect tissues from high concentrations of cytokines that can cause apoptosis, there is a mechanism of immune tolerance of innate immunity. Lipopolysaccharide (LPS) tolerance of monocyte-macrophages is a phenomenon in which cells reduce their sensitivity to repeated exposure to LPS. This condition is characterized by a decrease in the ability of macrophages to produce proinflammatory cytokines and promotes resolution of inflammation. We hypothesized that in atherosclerosis, tolerance violations in monocyte-macrophages are possible. The study included patients who were admitted to the department of cardiac surgery, Moscow Regional Research and Clinical Institute (MONIKI). Patients were divided into patients with coronary atherosclerosis (CAD) with detected stenosis in 2 or more arteries and healthy controls without stenosis in the arteries according to the results of coronary angiography. In the present study, we examined the ability of macrophages from 13 patients with CAD and 11 patients without CAD to develop tolerance to LPS. To do this, we isolated CD14+ monocytes from the blood by positive selection using immunomagnetic separation and subjected them to two sequential LPS stimulations, immediately after cell isolation and after 6 days of culture. The secretion of cytokines TNFα, IL-1b, IL-6, IL-10, IL-8, and CCL2 was measured in cell culture supernatants using by ELISA. Our results showed impaired macrophage tolerance for CCL2 secretion and improved tolerance for IL-8 secretion in macrophages from patients with CAD compared with patients without. Since IL-8 and CCL2 are chemoattractants for other immune cells, it can be assumed that the observed impairment of macrophage tolerance to LPS in atherosclerosis increases the infiltration of other monocytes into the inflammatory site, contributing to the chronicity of inflammation.
Monocytes and macrophages transmit inflammatory signals to each other via extracellular vesicles
Authors: Erdyneeva D. B. , Stavskaya N. I. , Postnov A. Yu.
Published: September 2024

Monocytes and macrophages play an important role in the development of inflammatory diseases, including sepsis, etc. In addition to their role as “scavengers,” macrophages secrete various substances (mainly cytokines and chemokines), which have a systemic effect and modulate the microenvironment of the inflammatory focus. Disruption of their normal function can cause various immune pathologies and changes in tissue homeostasis. Macrophages are able to transmit signals to other cells in the area of inflammation, including various cytokines and other compounds. Usually, they are secreted directly into the extracellular space. However, the lifetime and range of action of these substances may be limited. An alternative method of intercellular communication is the packaging of substances into extracellular vesicles, which can help in signal propagation. Extracellular vesicles are small particles with a bilayer lipid membrane that transport various biologically active substances. There are different types of extracellular vesicles, each of which can have its own specific effect on other cells. Due to the presence of specific receptors on the surface of the vesicles, they can make selective delivery of biological molecules to certain cells. Vesicles can contain various components, such as nucleic acids, proteins, lipids, and even individual cell organelles. Therefore, it is not surprising that vesicles are able to modulate physiological processes in the body and be involved in the pathogenesis of various diseases. Establishing the mechanisms of vesicle participation in the development of inflammatory diseases, including chronic ones, is extremely important. The aim of the present study was to determine whether extracellular vesicles are capable of modulating the immune response. To do this, we assessed cytokine secretion by macrophages treated with vesicles from LPS-stimulated monocytes and macrophages. It was found that cells that received vesicles from LPS-activated monocytes and macrophages secrete more pro-inflammatory signaling molecules: the cytokine IL-6 and the chemokine IL-8. The results demonstrate that intercellular interaction and transmission of the inflammatory signal of monocytic cells also occurs through extracellular vesicles. In the future, additional research is needed to understand the full picture of what substances in the extracellular vesicles of monocytes and macrophages allow them to have an immunomodulatory effect not only on each other, but also on other types of cells.
The immune response formed by the introduction of a DNA vector containing a cDNA fragment of the human thyroid-stimulating hormone receptor gene into transgenic mice
Authors: Zubkov A. V. , Butova L. G. , Kuzmina N. S. , Yakovleva I. V. , Gavrilova N. F. , Kornoukhova A. A. , Sidorov A. V. , Khraim Wael B. V. , Kuzmenko V. V. , Zubkova I. V. , Fadeev V. V.
Published: September 2024

The number of patients with autoimmune thyroid diseases (Graves’disease, Hashimoto’sthyroiditis) is increasing globally. The most important part in the diagnosis of Graves’ disease (GD) is the detection of autoantibodies to the thyrotropin receptor (TSHR) in Graves’ patients’ sera. For the differential diagnosis of antibodies to thyroid antigens, it is promising to use tests based on monoclonal antibodies to TSHR, which can be obtained not only as a result of immunization with native or recombinant TSHR protein, but also through DNA immunization with genetically engineered constructs containing fragments of the TSHR gene. Based on mRNA we isolated from the thyroid tissue in GD, a number of fragments of the thyrotropin receptor gene were cloned, suitable for DNA immunization of animals. The purpose of this work is to evaluate the immunogenic properties of one of the constructed vectors, pVAX1-TSHR (1160), in a mouse model. The successful inclusion of the extracellular domain gene fragment of the human TSHR (1160), which was transfected into CHO cells as a part of the pVAX1 vector was confirmed by immunoblotting and ELISA. The immune response formed to the injection of the pVAX1 vector into BALB/c mice, containing a fragment of the human TSHR gene, was detected in different versions of ELISA. Immunization of animals with the DNA vector pVAX1-TSHR according to an experimentally selected scheme was effective for the formation of mouse splenocytes, secreting antibodies to TSHR, which were used for successful hybridization. This was confirmed by the results of determining antibody production to TSHR in murine blood sera. The level of antibody production remained high (titer more than 1:10.000) at the 8th week of the experiment. As a result of selection of individual clones according to the criteria of proliferative activity and stability of antibody production, the most stable cultures secreting mAbs against TSHR were selected.
Non-HD-Chorea: An Expanding Universe
Authors: Cardoso Francisco , Maia Débora , Maciel Ricardo , Carr Jonathan , Hatano Taku , Durr Alexandra , Poewe Werner
Published: September 2024

The main aim of this article is to provide a practical diagnostic approach to phenocopies of Huntington disease (HD). These are defined as conditions characterized by a phenotype similar to HD but with no pathogenic repeat expansion in the HTT gene. Their frequency ranges from 2% to 40% depending on ethnicity and geographic location. The most frequent genetic causes are Huntington Disease-like 2/JHP3, followed by spinocerebellar ataxia genes (SCA17/TBP, SCA12/PPP2R2B and SCA3/ATXN3, CACNA1A), and frontotemporal dementia genes (C9orf72, and VCP). There is current recognition that a growing number of acquired causes can mimic HD. Autoimmune causes such as primary antiphospholipid syndrome, paraneoplastic chorea, and anti-IGLON5 antibodies, as well as stroke, and diabetes mellitus type 2 complications are the leading acquired causes of HD phenocopies. Finally, we provide practical recommendations on how to approach HD phenocopies considering age at onset, ethnicity, and geographic location of individuals.
Guía Pedagógica "Yo aprendo una segunda lengua, el español"
Authors:   Instituto Superior Tecnológico Tena, Gómez Rivas Inés Beatriz , Duarte Mora Martha Janina ,   Instituto Superior Tecnológico Tena, Lozada Zabala Verónica Lucia ,   Unidad Educativa José María Román (Riobamba), Alvarado Shiguango Tania Angélica ,   Instituto Superior Tecnológico Tena
Published: September 2024

¿Qué son las Guías Pedagógicas? La respuesta básica y más adecuada la hallamos en la página web del Ministerio de Educación del Ecuador: Las Guías Pedagógicas son un conjunto de fichas que contienen actividades articuladas con los Niveles de Logro de los Estándares de Aprendizaje de las Áreas Curriculares de Lengua y Literatura, Ciencias Naturales, Ciencias Sociales y Matemática de los Subniveles de Educación General Básica y Nivel de Bachillerato, que tiene como objetivo contribuir a la continuidad educativa, el refuerzo académico y la prevención de pérdida de aprendizajes en situaciones de emergencia (MINEDUC, 2024); estas guías pueden ser utilizadas por los docentes o desarrolladas por los estudiantes; en el caso del presente texto hay una amplia gama de ejercicios para que los niños angloparlantes puedan desarrollar la adquisición del lenguaje español con confianza, lo que generará un importante aprendizaje de su segunda lengua.
Gestión de la felicidad y emprendimiento universitario:revisión de la literatura
Authors: Cuesta-Valiño Pedro , Yustres-Duro Pilar , Melendo-Rodríguez-Carmona Laura , Núñez-Barriopedro Estela
Published: September 2024

the increasing importance of the concept of happiness management in the last 10 years makes it necessary to review the literature toassess the main lines of research and the possible gaps. Additionally, there is a need for more business and entrepreneurship education withinuniversities. Therefore, this paper aims to contribute to the advancement of happiness management in the context of university entrepreneurship,where the existing relationships between the constructs happiness management and entrepreneurship and happiness and entrepreneurship areidentified. In this work a literature review is made, where through five filtering processes a total of 391 articles selected as object of study arereached. Subsequently, the state of the art is discussed and the thematic areas of research on university entrepreneurship in relation to happinessmanagement are identified, which are: the analysis of management and business organization, the business models, the types of entrepreneurs-hips, the financing and the capabilities and training as the most prominent topics. In the end, the contributions of this study to the state of the artand the conclusions reached are mentioned, determining, through the identification of the different thematic areas, the roadmap for the imple-mentation of future happiness management strategies within university entrepreneurship
Escala de Clima de Innovación: análisis psicométrico en trabajadores peruanos
Authors: Dominguez-Lara Sergio , Fernández-Arata Manuel , Bárrig-Jó Patricia
Published: September 2024

the changes caused by the COVID-19 pandemic pushed organizations to attempt to remain current and competitive. Thus, the abilityto respond to new demands and adapt to shifting conditions was an unavoidable requirement, which implies innovating in the development oftheir processes. In that sense, the growing importance of innovative work behaviors in the development of organizations has driven researchersto investigate mechanisms that foster such behaviors in workers. The objective of this study was to analyze the psychometric properties of theInnovation Climate Scale (ICS). The instrumental study involved 273 Peruvian workers (50.916 % male) ranging in age between 22 and 76 yearsold (Mean = 45.224), employed for the most part in the private sector (75.092 %). The psychometric analysis explored item clarity and relevanceby means of assessment by expert judges (content validity). Internal structure was assessed via confirmatory factorial analyses, both of obliquemodels and bi-factor. Finally, scoring reliability (alpha coefficient) and construct reliability (omega coefficient) were estimated. This study findsthe ICS items to be clear and relevant, a greater empirical support for the unidimensional model as its internal structure, and an adequate relia-bility. In conclusion there is favorable evidence of validity and reliability for the application of the ICS in Peruvian companies as a useful tool tomeasure the innovative climate perceived by its workers, providing information for decision making and planning of innovation strategies andorganizational creativity
Ansiedad financiera en el gobierno corporativo mexicano:efecto de la autoeficacia y neuroticismo
Authors: Nava-Govela Alfredo , Beltrán Godoy Jaime H. , Mata-Mata Leovardo
Published: September 2024

financial anxiety affects board members in their judgment concerning strategic decisions for their organizations. Both, financial self-effi-cacy and neuroticism bear on the financial anxiety of board members. By applying a structural equation model, this paper analyzes the effect ofboth factors on the financial anxiety of board members in public, private, and non-profit corporations in Mexico. The approach of the structuralequation model is quantitative, non-experimental, and cross-sectional; and is based on a sample of 155 board members of Mexican institutions.The results show that financial self-efficacy affects negatively financial anxiety; whereas higher degrees of neuroticism affect positively financialanxiety. Following these results, it is advisable to consider these personality traits as relevant criteria for the selection of board members in Mexicaninstitutions. Corporate governance policies and practices should also be developed to ameliorate the effect of neuroticism and incentivize the effectof financial self-efficacy in the judgments of board members regarding organizational strategy. The methodology of this study is useful for boardsin institutions of other countries.
Morphological characteristics of wound healing with aloe extract, hydrogel, and their combination: experimental research
Authors: Cherdantseva Tatiana M. , Fedoseev Andrey V. , Inyutin Alexander S. , Nekrasova Marina S. , Kachkurkina Antonina A. , Antoshkin Iaroslav A.
Published: September 2024

BACKGROUND: Currently, there remains a high incidence of skin damage due to trauma, chronic diseases, burns, so it is important to study the issues of regeneration and treatment of skin wounds.
AIM: To conduct a morphological analysis of wound healing using aloe extract, hydrogel, and their combination in the experiment.
MATERIALS AND METHODS: The study involved 40 sexually mature guinea pigs, which were divided into a control group and 4 experimental groups (independent wound healing, application of aloe extract, hydrosorb gel, layer-by-layer application of drugs). Histological skin preparations were prepared on days 3, 7, 14, and 28 of the experiment. In each microslide, in 10 fields of view of the microscope at a magnification of ×50, morphometric parameters were measured in micrometers (µm): the thickness of the purulent-necrotic scab, inflammatory (leukocyte) infiltrate, granulation tissue, the length of the newly formed epithelium on days 3, 7, 14; the thickness of the epithelium, its length and the thickness of the connective tissue in the central part of the regenerate on the 28th day. All data were subjected to statistical processing.
RESULTS: The medications led to a decrease in the inflammatory reaction, acceleration of the formation of granulation tissue, and partial wound epithelization by day 7 of the experiment; however, more pronounced signs of wound healing were observed with layer-by-layer application of aloe extract and hydrogel. By day 14, regardless of the application method, the use of medications demonstrated signs of enhanced wound healing. Thus, the length of the epithelium increased by 1.2–1.6 times, the depth of granulation tissue increased by 1.0–1.2 times compared to the control group. By the end of the experiment, all animals had complete closure of the wound with scar formation, while in the experimental groups showed signs of skin remodeling with appendages.
CONCLUSION: Morphological analysis showed that aloe extract, hydrosorb gel, and their combination accelerated the wound healing processes of full-thickness skin wounds in the experiment.
Alice in Wonderland syndrome or delirium? a case of a five-year-old girl with hallucinations of snakes
Authors: Gülcü Üstün Nur Seda
Published: September 2024

Alice in Wonderland syndrome was first defined by the British psychiatrist John Todd in 1955 as a disorder characterized by episodes of visual illusions, body shape, temporal and spatial distortions. Delirium is a clinical neuropsychiatric disorder showing global encephalopathic dysfunction. In this case, we will present a patient of a 5-year-old girl with the complaint of seeing snakes. Our aim is to help make a differential diagnosis between the two diseases in a patient with similar complaints.
A literature review of allergen properties in fish collagen and its derivative products
Authors: Soedarini Bernadeta , Octavia Esther
Published: September 2024

Fish are generally categorized as allergens that cause reactions mediated by Immunoglobulin E (IgE). Fish collagen is one of the causes of allergic reactions, ranging from mild symptoms such as nausea and itching to severe symptoms such as anaphylaxis across all ages. Previous research has not specifically or comprehensively explained the characteristics of fish collagen and its derivatives as allergens. This study aims to address this gap by explaining the properties, contributing factors, and potential hazards of fish collagen and its derivatives as allergens. This research employed a literature review summarizing several main studies to produce comprehensive findings. The structure of collagen, contaminant allergens, and fish type can affect the allergenicity of fish collagen. Processing methods, such as heating, acid or enzyme treatment, and washing, can determine allergenicity. The structure of fish collagen can change upon heating, but its allergenicity cannot be reduced. Fish collagen is also known to have good resistance to enzymes; therefore, it can easily bind to immune cells. Another factor was age, in which adults had a greater frequency of IgE binding to fish collagen than did children and adolescents. They were included as potential allergens based on research results and existing data regarding allergy cases and their potential hazards. Therefore, there is a need for further research on allergies to fish collagen and its derivatives, especially in countries that do not require the inclusion of allergens where food safety matters.
Pengaruh substitusi tepung buah mangrove (Sonneratia alba) terhadap karakteristik fisikokimiawi dan sensori roti tawar
Authors: Sumartini Sumartini , Hasibuan Nirmala Efri , Azka Aulia , Ratrinia Putri Wening , Suryono Muhamad
Published: September 2024

Roti tawar adalah produk makanan berbahan baku tepung terigu yang memiliki kandungan gluten tinggi. Gluten dapat berdampak negatif bagi kesehatan terutama pada individu dengan kondisi kesehatan tertentu, yaitu penyakit seliak, intoleransi gluten yang bersifat nonseliak, dan penyakit usus lainnya. Tepung alternatif diperlukan untuk mengurangi kandungan gluten pada roti tawar. Penelitian ini bertujuan untuk menentukan konsentrasi terbaik substitusi tepung buah mangrove terhadap roti tawar berdasarkan karakteristik sensori dan daya kembang. Perlakuan pembuatan roti tawar melalui substitusi tepung terigu dengan tepung buah mangrove, yaitu 0, 10, 20, 30, dan 40%. Parameter yang dianalisis meliputi proksimat, kadar serat kasar, daya kembang, hardness, cohesiveness, dan hedonik. Hasil penelitian menunjukkan bahwa komposisi kimia roti tawar, yaitu kadar air 13,21-17,86%, lemak 9,53-14,51%, protein 5,28-8,5%, abu 1,64-1,84%, karbohidrat 60,57-67,13%, serat kasar 2,91-8,26%, daya kembang 100,35-137,70%, nilai hardness 20,92-68,45 N, dan cohesiveness 0,58-0,82. Makin tinggi konsentrasi tepung buah mangrove pada roti tawar, maka makin menurunkan tingkat kesukaan panelis. Roti tawar substitusi tepung buah mangrove 10% memiliki tingkat kesukaan panelis tertinggi dengan rasa yang gurih, aroma harum, tekstur lembut, warna crust cokelat kekuningan dan crumb putih krim dan memiliki daya kembang yang baik.
Pengaruh penambahan minyak asiri kulit jeruk manis pada edible coating kitosan terhadap kualitas filet ayam
Authors: Siswanti Siswanti , Aunillah Nadiya Fistianati , Widowati Esti , Atmaka Windi , Widowati Dyah
Published: September 2024

Daging ayam merupakan salah satu sumber protein hewani yang mudah didapatkan dalam bentuk karkas utuh, potongan bagian-bagian tertentu, atau filet. Umur simpan filet ayam relatif rendah dan memiliki risiko kerusakan fisikokimia dan mikroba yang tinggi selama proses penyimpanan. Upaya untuk menjaga kualitas daging filet ayam selama penyimpanan salah satunya melalui aplikasi edible coating dari kitosan kombinasi dengan minyak asiri. Penelitian ini bertujuan menentukan konsentrasi terbaik penambahan minyak asiri kulit jeruk manis pada edible coating kitosan filet ayam selama 12 hari penyimpanan suhu dingin berdasarkan parameter susut masak, TPC, pH, TBA, dan TVB. Penelitian dilakukan melalui pembuatan edible coating menggunakan beberapa konsentrasi minyak asiri kulit jeruk manis, pengaplikasiannya pada filet ayam, dan penyimpanan suhu dingin (4oC; 12 hari). Variasi konsentrasi minyak asiri kulit jeruk manis pada edible coating, yaitu 0%, 0,25%, 0,5%, 0,75%, dan 1% (v/v). Perlakuan terbaik ditentukan dengan metode Bayes yang dilanjutkan Independent Samples T-Test terhadap sampel tanpa perlakuan coating. Hasil penelitian menunjukkan perlakuan konsentrasi 1% minyak asiri kulit jeruk manis merupakan perlakuan terbaik selama penyimpanan 3 hari (suhu dingin; 4oC) dengan kisaran nilai susut masak 16,65-25,17%; pH 5,39-6,49; TPC 4,46-7,50 log cfu/mL; TBA 0,061-0,258 mg malonaldehid/kg; TVB 15,81-17,54 mgN/100 g. Kualitas sampel perlakuan terbaik berbeda signifikan dan lebih baik daripada sampel tanpa coating berdasarkan semua parameter (kecuali TVB). Oleh sebab itu, lapisan kitosan dan 1% minyak asiri pada filet ayam mengindikasikan perlindungan potensial terhadap kualitas fisikokimia dan mikroba selama penyimpanan suhu dingin.
Formulasi dan karakterisasi paper soap antibakteri dengan penambahan nanokitosan dari cangkang kepiting bakau
Authors: Luthfiyana Novi , Asikin Nor , Khoirunnisa Mutia , Hidayat Taufik
Published: September 2024

Inovasi pembuatan produk sabun terus dikembangkan salah satunya berbentuk paper soap dengan penambahan nanokitosan yang memiliki manfaat sebagai antibakteri. Tujuan penelitian ini adalah mendapatkan kitosan berukuran nano dan menentukan formula terbaik paper soap antibakteri dengan penambahan nanokitosan cangkang kepiting bakau (Scylla sp.) melalui karakterisasi secara fisikokimia dan mikrobiologi. Pembuatan nanokitosan menggunakan cangkang kepiting bakau (Scylla sp.) menggunakan metode gelasi ionik. Formulasi paper soap dengan penambahan nanokitosan, yaitu 0; 0,25; 0,5; 0,75; dan 1%.  Hasil penelitian menunjukkan nanokitosan cangkang Scylla sp. berukuran 67,07 nm. Paper soap dengan penambahan nanokitosan Scylla sp (0; 0,25; 0,5; 0,75; dan 1%) menghasilkan nilai ph 9,18-9,27, kadar air 18,25-32,00% dan alkali bebas 0,003-0,010%. Seluruh konsentrasi paper soap bertekstur halus, memiliki aroma jasmine dan menunjukkan warna beige. Aktivitas bakteri Gram positif Staphylococcus aureus pada paper soap menghasilkan zona bening 3,5-14 mm dan pada bakteri Gram negatif mampu menghambat Echerichia coli 4,50-11,50 mm. Paper soap antibakteri dengan konsentrasi nanokitosan 0,5% adalah formulasi terbaik dalam menghambat pertumbuhan bakteri Gram positif (S.aureus) dan bakteri Gram negatif (E.coli). Paper soap antibakteri dengan penambahan nanokitosan cangkang (Scylla sp.) pada penelitian ini memenuhi kriteria sabun sesuai standar SNI.
Memahami Kebutuhan Belajar Generasi Z melalui Asesmen Personal Berbasis Artificial Intelegence
Authors: Bafadal Rifqi , Rosyid Fatiya
Published: September 2024

Penggunaan teknologi yang telah memasuki era AI menuntut pendidikan di Indonesia juga perlu ditingkatkan juga sesuai dengan perkembangan zaman, sehingga perlu adanya pembahasan terkait penggunaan AI dalam proses belajar mengajar. Artikel ini bertujuan untuk memahami kebutuhan belajar Generasi Z secara umum dan membahas asesmen personal berbasis AI untuk Generasi Z. Metode yang digunakan adalah penelitian kualitatif dengan pendekatan kepustakaan. Disebutkan bahwa bahwa Generasi Z memiliki kebutuhan belajar yang unik dan berbeda dengan generasi sebelumnya. Mereka menyukai pembelajaran interaktif, menggunakan teknologi, dan belajar hal-hal yang relevan dengan kehidupan mereka. Asesmen personal berbasis AI yang akan dibahas terdiri dari kuesioner, tes, dan analisis data dengan menggunakan AI ChatGPT. Kuesioner digunakan untuk mengumpulkan data tentang kebutuhan belajar, gaya belajar, dan bakat. Tes digunakan untuk mengukur kemampuan peserta didik terkait pengetahuan IPS. Analisis data menggunakan teknik AI ChatGPT untuk mengidentifikasi pola dan kebutuhan belajar peserta didik. Rekomendasi pembelajaran diberikan berdasarkan hasil analisis data. Uji coba asesmen personal berbasis AI menunjukkan bahwa asesmen ini cukup efektif dalam membantu memahami kebutuhan belajar peserta didik, memahami gaya belajar, maupun bakat peserta didik dan kemudian guru bisa memberikan rekomendasi pembelajaran yang sesuai dengan kebutuhan mereka berdasarkan data dari hasil assesmen.
Pengaruh Model Kooperatif Tipe TGT Berbantuan E-LKPD Crossword Puzzle terhadap Hasil Belajar IPA Kelas VIII
Authors: Ilma Izza Nuril , Sutrisno Sutrisno , Lestari Lia Puji
Published: September 2024

Tujuan penelitian ini adalah menuangkan hasil pengalaman praktik mengajar mandiri selama PPL PPG peneliti dalam meningkatkan hasil belajar IPA melalui model kooperatif tipe TGT berbantuan E-LKPD crossword puzzle. Metode dalam penelitian ini adalah penelitian pre-eksperimental dengan desain penelitian One Grup Pretest-Posttest. Penelitian ini menggunakan satu kelas eksperimen tanpa adanya kelas kontrol. Subjek penelitian ini adalah peserta didik kelas VIII SMPN 5 Malang dengan jumlah 32 orang dan objek penelitiannya hasil belajar peserta didik materi senyawa. Instrumen yang digunakan meliputi 1) pretest-posttest, 2) Lembar Kerja Peserta Didik, 3) lembar wa­wancara respon guru dan peserta didik terhadap pembelajaran, 4) lembar observasi, dan 5) dokumentasi. Untuk menjawab rumusan penelitian, analisis data yang diguna­kan merupakan data kuantitatif yang kemudian di deskripsikan. Hasil penelitian menunjukkan bahwa ada pengaruh model pembelajaran koopertif tipe TGT berbantuan E-LKPD crossword puzzle yang signifikan terhadap hasil belajar peserta didik. Selain itu juga dapat meningkatkan keterampilan sosial mereka melalui kegiatan berkelompok dan meningkatkan keaktifan selama proses pembelajara.
Literatur Riviu: Pembelajaran Berdiferensiasi dalam Kurikulum Merdeka Di Sekolah Dasar
Authors: Solikah Siti
Published: September 2024

Penelitian ini bertujuan untuk mengevaluasi dampak dari setiap artikel yang dianalisis terhadap proses pembelajaran, dengan fokus pada penyesuaian metode pembelajaran sesuai dengan kebutuhan individual siswa. Tinjauan pustaka digunakan sebagai metode utama, memungkinkan analisis mendalam terhadap berbagai literatur dan artikel untuk mengidentifikasi hubungan yang signifikan serta menemukan strategi dan model pembelajaran yang efektif. Implementasi pembelajaran diferensiasi yang disesuaikan dengan kebutuhan siswa diharapkan dapat meningkatkan motivasi intrinsik dan hasil belajar siswa secara keseluruhan. Pendekatan ini tidak hanya mempertimbangkan gaya belajar individu tetapi juga mengintegrasikan prinsip-prinsip kurikulum merdeka yang memberdayakan siswa sebagai subjek aktif dalam proses belajar. Hasil penelitian ini diharapkan dapat berkontribusi dalam mengembangkan praktik pembelajaran yang lebih responsif dan relevan, sesuai dengan evolusi kebutuhan pendidikan kontemporer.