bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALYSIS OF DOMAIN SPECIFICITY OF THE PROTECTIVE CHIMERIC ANTIBODY ch14D5a AGAINST GLYCOPROTEIN E OF TICK-BORNE ENCEPHALITIS VIRUS
Authors: Baykov I. K. , Emelyanova L. A. , Sokolova L. M. , Karelina E. M. , Matveev A. L. , Babkin I. V. , Khlusevich Ya. А. , Podgornyy V. F. , Tikunova N. V.
Published: July 2018

A drug for the prevention and therapy of tick-borne encephalitis virus is being developed on the basis of the protective chimeric antibody ch14D5a. At the same time, the epitope recognized by this antibody on the surface of glycoprotein E has not been localized yet. The aim of this work was to identify the domain of glycoprotein E, to which the protective antibody ch14D5a binds. As a result, four recombinant variants of glycoprotein E were generated using the bacterial expression system: (1) the rE protein containing the domains D1, D2, and D3 of glycoprotein E; (2) the rED1+2 protein containing domains D1 and D2; (3) the rED3_301 protein, which is domain D3 of glycoprotein E, and (4) the rED3_294 protein comprising domain D3 and a hinge region connecting domains D1 and D3. The rED3_294 and rED3_301 proteins were obtained in soluble monomeric form. The rE and rED1+2 proteins were extracted from the inclusion bodies of Escherichia coli. Using Western blot analysis and surface plasmon resonance analysis, it was demonstrated that the protective chimeric antibody ch14D5a and its Fab fragment bound specifically to domain D3 of glycoprotein E. Since the antibodies recognizing epitopes on the surface of domain D3 do not tend to cause antibody-dependent enhancement of the infection as compared to antibodies directed to domains D1 and D2, the data obtained confirm the promise of using the antibody ch14D5a in the development of a therapeutic preparation against the tick-borne encephalitis virus.
Impact of biotic stress management technologies on yield, economics and energy indices of pigeon pea (Cajanus cajan) grown in Central India
Authors: Singh Y. P. , Tomar S.P.S. , Singh Sudhir
Published: July 2018

The major biotic stresses limiting productivity of pigeon pea includes weeds and various diseases like wilt, sterility mosaic virus, blight and pests as pod-borer, pod-fly in field and bruchids in field as well as in storage. Results of on farm trials revealed significant impact of adoption of management techniques of biotic stresses on seed yield, net profit and benefit cost ratio as compared to existing practices of pigeon pea cultivation. Scientific management of weed, pod borer and wilt was increased in seed yield by 26.2, 46.1 and 12.2%, while saving of seed by 23.6% from bruchids compared with existing practice, respectively. Among biotic management practices, higher additional cost was observed on weed management (Rs. 2,974 ha-1) and it was minimum on pod borer management (Rs. 798 ha-1) compared with existing practices. Accordingly, additional maximum net returns were obtained with pod borer (Rs. 24,805 ha-1) and minimum with wilt (Rs. 9,401 ha-1). Interventions of biotic stresses management were significantly influenced the output, use-efficiency, productivity and net gains of energy compared to existing practices. Maximum additional net energy gain was in management of weed (25,649 MJ ha-1) followed by pod borer (13,349 MJ ha-1), bruchid (8,390 MJ ha-1) and wilt (5,325 MJ ha-1). After harvest of second crop of pigeon pea, organic carbon, bulk density, infiltration rate and available N, P, K, S and Zn were significantly increased with weed and wilt management over existing practice. Management of biotic stresses by proper technologies increased the productivity of pigeon pea of three folds (2.12 to 2.33 t ha-1) compared to its average productivity of India and also increased economic benefits and energy outcomes.
Macedonians of Islamic Religion in the Context of Identity Theories
Authors: Kulavkova Katica
Published: July 2018

In line with the theories of variability, fluctuation and instability of ethno-cultural identities, this paper deals with some sensitive issues surrounding the creation of new (sub-ethnic and sub-cultural) microidentities within one nation, in this case within the Macedonian nation. The research focuses on the initiative for declaring one part of the Macedonian nation, the Macedonians of Islamic religion, to be a separate ethnic group in 2011. It analyses the regional and historical background from which this initiative originated, mostly as an echo of the multicultural strategies and policies in the European and international context. It shows how the unstable politics destabilized the already fragile and fluctuating identity of this group toward an identity of resistance or even heresy, inspite of having preserved their primary Slavic linguistic and cultural identity. The paper argues that the Macedonians of Islamic religion are a part of the Macedonian social, cultural and religious reality and should therefore be recognized as a specific cultural-religious community within the Macedonian national entity. This issue is seen as very important in the present context, since the Macedonian identity is preasured and relativized itself. The paper underlines that the Macedonian national identity is inclusive, layered, more general and complex than its religious factor. Therefore this researcher proposes inclusive state policies for all Macedonians regardless of religious affiliation, inclusive civilizational strategies with inter-connective spiritual values (inter-religious palimpsests and symbiosis) and inclusive state secular strategies as protection against religious radicalisms, atavisms and conflicts.
Gender Domesticity Reinterpreted: Housework Division in Dual-Work Moroccan Families
Authors: Meryem Rostom
Published: July 2018

Research on the gendered division of household labour suggests that spouses’ inequitable housework division is determined by economic, cultural and/ or pragmatic considerations. While these factors are partially supported by the literature on household labour division, results of this study further suggested that women perform more housework than their spouses out of choice and are not necessarily unhappy with their unbalanced share. The data for the study were drawn from in-depth semi-structured interviews administered to 30 Moroccan female primary school teachers. Building on Thompson’s (1991) distributive justice framework, this paper focuses on examining women’s underlying motivation for doing a far greater proportion of housework tasks than do their husbands in spite of working for pay. It also states the implications of such a deliberate choice.
Pemurnian Silikon (Si) Hasil Reduksi Silika dari Fly Ash Batubara
Authors: Andarini Novita , Haryati Tanti , Yulianti Rika
Published: July 2018

Fly ash merupakan limbah hasil pembakaran batubara yang mengandung beberapa senyawa kimia yang dapat dimanfaatkan.. Salah satu senyawa kimia dengan persentase tinggi di dalam fly ash adalah senyawa silika (SiO2). Penelitian ini bertujuan untuk mendapatkan silikon murni hasil dari reduksi silika dari fly ash batubara. Silika diperoleh dengan metode ekstraksi yaitu dengan menggunakan NaOH 3M dan HCl 1M, dilanjutkan dengan pemurnian silika menggunakan HCl 37%. Silika murni yang diperoleh kemudian direduksi menggunakan metode metalotermal dengan logam magnesium. Komposisi massa silika dan magnesium yang digunakan dioptimasi dengan empat variasi perbandingan massa silika:magnesium masing- masing 1:0,8 ; 1:1,5; 1:2 dan 1:2,5. Produk optimum hasil dari proses reduksi kemudian dimurnikan menggunakan 150mL HCl 2M lalu dipanaskan pada suhu 80oC sambil distirer selama 3 jam. Hasil analisa XRF (X-Ray fluorescence) menunjukkan persentase kadar silika yang diperoleh dari proses ekstraksi yaitu 79,72% dan meningkat kadar kemurniannya menjadi 93,76% setelah dilakukan pemurnian. Karakterisasi produk dari reaksi reduksi silika oleh magnesium menggunakan XRD dengan program software Match 3 secara keseluruhan terhadap semua variasi massa silika:magnesium menunjukkan bahwa silikon yang dihasilkan hanya diperoleh pada variasi silika:magnesium 1:0,8 yaitu sebanyak 4,8%. Hal ini ditunjukkan dengan munculnya puncak 2 theta pada titik 42.77 o, 48.43o dan 78.39o. Kemurnian silikon kemudian meningkat menjadi 5,6% setelah dilakukan pemurnian.Kata Kunci: fly ash, pemurnian, reduksi, silika, silikon
Visitas a João Paulo Borges Coelho: leituras, diálogos e futuros
Authors: Cardoso Rodrigo Octávio
Published: July 2018

Visitas a João Paulo Borges Coelho: leituras, diálogos e futuros é uma coletânea de 13 ensaios de notáveis especialistas em literaturas africanas de língua portuguesa, discutindo a obra de João Paulo Borges Coelho, um dos autores mais profícuos das literaturas em língua portuguesa nos últimos anos. Trata-se de textos que examinam algumas das linhas de força da obra do escritor moçambicano, explorando temas, imagens e questões teóricas caras à crítica literária contemporânea. Promovem, assim, um debate enriquecedor que ilumina diversas problemáticas relativas às literaturas africanas, à teoria pós-colonial e à crítica literária, em suas relações com outras disciplinas como a história, a sociologia e a ecocrítica. A coletânea também apresenta, ao final, um conto inédito do autor analisado.
O Atlântico negro encontra o Oceano Índico: gerando novos paradigmas para um transnacionalismo do Sul Global – Perspectivas Literárias e Culturais
Authors: Hofmeyr Isabel
Published: July 2018

Com a recente virada transnacional nas ciências humanas e sociais, as  questões relacionadas ao translocalismo passaram a dominar a agenda acadêmica. Os estudos da África Austral orientados por perspetivas transnacionais basearam-se, geralmente, no modelo do Atlântico negro. Este artigo defende que é preciso complementar essa perspectiva com um engajamento sistemático com o Oceano Índico. O artigo descreve as principais tradições historiográficas associadas ao Oceano Índico, para realçar o modo como esses temas desafiam os pressupostos teorizados anteriormente com base no modelo do Atlântico negro. Na parte final do artigo, defende-se que a inclusão do Oceano Índico na cartografia da África do Sul ampliaria os mapas dos estudos culturais e literários desse país.
PENGGUNAAN KOMUNIKASI INSTRUKSIONAL OLEH PENDIDIK DI TAMAN PENDIDIKAN AL QUR’AN
Authors: April Ismaliza
Published: July 2018

The general purpose of this research was to explore the utilization of instructional communication by the teachers in the Al Qur’an Education Institution. Specifically the research aimed at describing the use of instructional communication by the teachers based on verbal communication, non-verbal communication, and communication with media. The resultf of the research shows that the teachers of the Al Qur’an Education Institution of Husnul Khatimah has been using instructional communication properly. Eventhough, this research gives some suggestions to improve the teachers` competence in using the instructional communication.
MENUMBUHKAN MINAT MEMBACA SEBAGAI UPAYA PENINGKATAN MUTU TENAGA PENDIDIK PAUD DI INDONESIA
Authors: Surtiawati Cucu
Published: July 2018

In this information and knowledge era, people tend to develop their expertise by obtaining information and knowledge as much as and as fast as possible. They will stand behind if they do not follow and adapt the advanced science and technology. Reading is a tool to obtain many kinds of information and reading habit is a precondition to build and develop reading society. However, reading has not become a habit aand reading interest is not high enough for most most of people in Indonesia. Reading skill and reading habit of the teachers of early childhood education are suspected unsatisfactory. This article discusses how to create reading interest and develop reading habit of the teachers of early childhood teachers as a means of improving their quality.
Edukasi Etika Bisnis dan Investasi Syariah Bagi Pengelola dan Anak Asuh Yayasan Islamadina
Authors: Aji Tony Seno , Isbanah Yuyun , Kistyanto Anang , Witjaksono Andre Dwijanto , Budiono Budiono
Published: July 2018

The orphanage's foundation has largely begun to grow the business. This is a form of development of financial independence. Orphanages no longer fully expect to fund from donors. In line with the above, the ability to manage ethical business and selection of sharia investment alternatives need to be understood by foundation managers and residents of orphanages. Training implementation methods using lecture, discussion, test, and simulation techniques. Training is carried out in two stages. The first stage of learning business ethics and sharia investment. The second stage is the simulation of investment instrument transactions. The target to be achieved is the acquisition of knowledge of managers/administrators and residents of orphanages related to business ethics and sharia investment instruments. Education of Business Ethics and Sharia Investment for the Managers and residents of Yayasan Islamadina was held on October 15, 2017. The activity was attended by 41 people. The results of the evaluation show that the level of satisfaction of the training and the ability of the resource persons are included in the high category. The results of the activities increased participants' understanding of business ethics and sharia investment instruments between before and after the training. This is demonstrated by the Wilcoxon Test results which show there are differences in pretest value with the posttest value, the conclusion there is increasing participants' understanding of the business ethics and sharia investment instruments between before training with after training.
Determination of Acrylamide in Portuguese Bread by UPLC-MS/MS: Metrological and Chemometric tools
Authors: Jesus Susana , Delgado Inês , Rego Andreia , Brandão Carlos , Dos Santos Rui Galhano , Bordado João , Castanheira Isabel Palmira
Published: July 2018

Acrylamide (AA) is known for its potential health hazards and it is present in processed potatoes, coffee, and bread. Wheat is still the most important cereal for bread making, however, the interest in its substitution by other grains is growing due to the consumer demand for novels and healthy foods, like oat and rye flour. The aim of this study was to analyze the AA content of confectioned bread in fifty-four different pastries and make an association of acrylamide contents and the place of production to identify the quality of the flour used. There was a wide variability in AA levels among different breads and within different bread varieties. The median of AA values was 787 µg/kg for whole grain bread, 783 µg/kg for oat bread and 253 µg/kg in rye bread.

With the cluster analysis, it was possible to conclude that besides the factors like baking temperature-time and fermentation time which affects AA formation in bread products, several other parameters such as the formulation, flour quality and the varieties of processing techniques, among others, play a crucial role in the AA formation.
A Vision-based navigation system for landing procedure
Authors: Del Pizzo Silvio , Papa Umberto , Gaglione Salvatore , Troisi Salvatore , Del Core Giuseppe
Published: July 2018

An autonomous vision-based landing system was designed and its performance is analysed and measured by an UAS. The system equipment is based on a single camera to determine its position and attitude with respect to a well-defined landing pattern. The developed procedure is based on photogrammetric Space Resection Solution, which provides the position and camera attitude reckoning starting from at least three, not aligned, reference control points whose image coordinates may be measured in the image camera frame. Five circular coloured targets were placed on a specific landing pattern, their 2D image frame coordinates was extracted through a particular algorithm. The aim of this work is to compute UAS precise position and attitude from single image, in order to have a good approach to landing field. This procedure can be used in addition or for replacement of GPS tracking and can be applied when the landing field is movable or located on a moving platform, the UAS will follow the landing pattern until the landing phase will be closed.
ISME activity on the use of Autonomous Surface and Underwater Vehicles for acoustic surveys at sea
Authors: Antonelli Gianluca , Arrichiello Filippo , Caiti Andrea , Casalino Giuseppe , De Palma Daniela , Indiveri Giovanni , Razzanelli Matteo , Pollini Lorenzo , Simetti Enrico
Published: July 2018

The paper presents an overview of the recent and ongoing research activities of the Italian Interuniversity Center on Integrated Systems for the Marine Environment (ISME) in the field of geotechnical seismic surveying. Such activities, performed in the framework of the H2020 European project WiMUST, include the development of technologies and algorithms for Autonomous Surface Crafts and Autonomous Underwater Vehicles to perform geotechnical seismic surveying by means of a team of robots towing streamers equipped with acoustic sensors.
Calibration standards for hydrophones and autonomous underwater noise recorders for frequencies below 1 kHz: current activities of EMPIR “UNAC-LOW” project
Authors: Biber Alper , Korakci Ata Can , Golick Alexander , Robinson Stephen , Hayman Gary , Ablitt Justin , Barrera-Figueroa Salvador , Buogo Silvano , Mauro Salvatore , Borsani Fabrizio , Curcuruto Salvatore , Linné Markus , Sigray Peter , Davidsson Per
Published: July 2018

The project entitled “UNderwater Acoustic Calibration standards for frequencies beLOW 1 kHz” (“UNAC-LOW”), currently active within the European Metrology Programme for Innovation and Research (EMPIR), is presented by describing its objectives and current activities. The project aims at developing the metrological capacity of the European Union (EU) for the calibration of hydrophones and autonomous recording systems for the frequency range between 20 Hz and 1 kHz, for which traceability is presently not fully available. In this way, EU metrological capacities for absolute measurement of underwater sound will be improved, with a direct effect on the implementation of regulation and EU Directives that require underwater acoustic measurements to be traceable. After having completed the initial project tasks regarding the review of existing methods and the design of the experimental setups, comparison measurements between the project partners are currently under way and their results will be validated and presented upon project end after first quarter of 2019. To ensure long-term operation of the calibration capabilities by each partner, a coherent EU metrology strategy for underwater acoustics will be developed as one of the main project outcomes. Current activities include the implementation of the calibration setups developed in earlier stages of the project for both hydrophones and autonomous recorders. The methods that shall be used for hydrophones are the pressure method in a closed chamber and the standing wave tube method. For autonomous recorders, in addition to the above methods, calibrations will be performed using free-field methods in different open-water test sites possessing suitable characteristics for low frequency measurements.
Point cloud processing techniques and image analysis comparisons for boat shapes measurements
Authors: Catalucci Sofia , Marsili Roberto , Moretti Michele , Rossi Gianluca
Published: July 2018

Photomodelling is a new and fast solution for 3D modelling, based on the same principles of photogrammetry. The comparison between photomodelling and the metrological technique of structured light 3D scanning, provided by the Creaform Go Scan 50 with metrological certification, is the aim of this paper, defining performances and verifying the potential of this innovative, simple and economical technique.
Editorial to selected papers from the 1st IMEKO TC19 Workshop on METROLOGY FOR THE SEA
Authors: Leccese Fabio
Published: July 2018

Editorial to selected papers from the 1st IMEKO TC19 Workshop on METROLOGY FOR THE SEA
Dummy
Yersinia pestis Strains: Selection Criteria, Usage Guidelines
Authors: Sazanova E. V. , Malyukova T. A. , Popov Yu. A.
Published: July 2018

Objective of the work was to develop selection criteria for the dummy Y. pestis strains, as well as principles of the setting-up a panel and its application for practicing laboratory and differential diagnostics of plague. Studied were the RF regulations, statutory documents and methodological recommendations on the laboratory diagnostics of plague and safety of works with microorganisms; training courses for specialists to qualify for work with the agents of particularly dangerous infections. Research method: analytical. Consequently, established were the term for “dummy strain”; selection criteria for the Y. pestis strains used in the practical course within the frames of the training programme “Microbiology and Laboratory Diagnosis of Plague”; and algorithm of the course application in view of biological risk mitigation during the process of education.
Melioidosis: Milestones of the Scientific Studies
Authors: Senina T. V. , Shubnikova E. V.
Published: July 2018

Anniversary of melioidosis agent discovery. Discussed are the key advances of world science in the sphere of Burkholderia pseudomallei ecology, epidemiology, clinical picture, and treatment of the disease. Apart from this, summarized are the data on the 50-years long study of melioidosis, carried out by the specialists of Plague Control Agency of the Russian Federation.
Bilateral Inferior Angle Ossicles of the Scapula: Pain Generators in a Young Woman
Authors: Gilde Alex K. , Henne Timothy D.
Published: July 2018

Case:

We present the case of a 16-year-old woman with refractory shoulder pain despite nonoperative treatment. The only shoulder pathology that was noted on advanced imaging was an unfused ossicle on the inferior angle of each scapula. She was successfully treated with simple excision bilaterally; as demonstrated by the shoulder scores, there was substantial improvement.

Conclusion:

In young patients with vague and refractory shoulder pain with essentially normal radiographic findings, an ossicle on the inferior angle of the scapula may be considered a pain generator. Excision of the ossicle may provide excellent definitive treatment after more common shoulder pathology has been ruled out.
Knee Osteoarthritis with Chronic Quadriceps Tendon Rupture Treated with Total Knee Arthroplasty and Extensor Mechanism Allograft Reconstruction
Authors: Piatek Allison Z. , Lee Patrick , DeRogatis Michael J. , Boyajian David A. , Issack Paul S.
Published: July 2018

Case:

A 51-year-old male construction worker with a history of chronic quadriceps tendon rupture presented with no active knee extension and tricompartmental knee osteoarthritis. He underwent simultaneous total knee arthroplasty and extensor mechanism allograft reconstruction. At 4 years postoperatively, the patient had pain-free knee function and active extension.

Conclusion:

The combination of a chronic quadriceps tendon rupture with lack of active knee extension and knee osteoarthritis is a rare and challenging problem. To our knowledge, this combined diagnosis and the treatment described in this case report have not been reported previously in the literature.
Biologic Therapies as Adjunctive Treatments in Rotator Cuff Repair
Authors: Mistry Jaydev , Henn R. Frank , Etcheson Jennifer I. , Gwam Chukwuweike U. , George Nicole E. , Delanois Ronald E.
Published: July 2018

* The incidence of rotator cuff tears is on the rise; however, despite advancements in surgical techniques to augment repairs, failure rates continue to pose a challenge for orthopaedic surgeons.

* A poor biologic environment is believed to be partly responsible for the inadequate tissue healing sometimes associated with rotator cuff tear repairs. Consequently, to provide the missing biologic component(s) required for adequate tendon repair, treatment strategies involving the use of adjunctive biologic therapies have been evaluated.

* Biologic rotator cuff repair therapies—such as platelet-rich plasma (PRP), patches and scaffolds, mesenchymal stem cells (MSCs), and cytokines—have been investigated in both animal models and human clinical trials.

* Biologic augmentation carries tremendous potential for improving rotator cuff healing, although the degree of short-term and long-term healing reported in the literature has varied.
From Static Spinal Alignment to Dynamic Body Balance: Utilizing Motion Analysis in Spinal Deformity Surgery
Authors: Diebo Bassel G. , Shah Neil V. , Pivec Robert , Naziri Qais , Patel Ashish , Post Nicholas H. , Assi Ayman , Godwin Ellen M. , Lafage Virginie , Schwab Frank J. , Paulino Carl B.
Published: July 2018

* Three-dimensional motion analysis is necessary to bridge the gap between static spinal radiographic alignment and dynamic body balance in the setting of pediatric and adult spinal deformities.

* Lessons learned from gait analysis in patients with adolescent idiopathic scoliosis may be applicable to patients with adult spinal deformity, with the potential to improve our understanding of dynamic compensatory mechanisms, the hip-spine complex, and proximal junctional kyphosis.

* Dynamic and functional assessments such as gait analysis are expected to be the future of pediatric and adult spinal deformity research, with potential clinical and surgical applications.
Trends in penaeid shrimp landings by sona boats at Visakhapatnam Fishing Harbour, Andhra Pradesh
Authors: Maheswarudu G. , Sreeram Miriam Paul , Dhanwanthari E. , Varma J. B. , Sajeev C. K. , Satya Rao S. , Narayana Rao K.
Published: July 2018

Sona boats operate mostly in the northern part of the Bay of Bengal up to sand heads. The boats (13-15 m OAL) worthy to conduct voyage fishing for 10-20 days exploit resources upto a depth of 100 m. The present study analysed the trends in penaeid shrimp landings by sona boats at Visakhapatnam Fishing Harbour, for the period from 2001 to 2010. During the period, annual fishing effort ranged from 4,77,710 to 16,31,507 h with an average of 10,15, 230 h. Annual penaeid shrimp catch varied from 1,409 to 7,496 t, average being 4,892 t. Average catch per hour (CPH) was estimated at 4.81 kg. Annual penaeid shrimp contribution from the sona boats to the total fish landings was 10.2 to 22% (average 15.9). Both fishing effort and penaeid shrimp catch showed increasing trend during the period. Penaeid shrimp fishery was supported by 14 genera/species dominated by Metapenaeus monoceros followed by M. dobsoni. Mean annual species composition and CPH for each species were computed for two span, first being 2001-2005 and the second during 2006-2010. The CPH for the penaeid shrimps increased by 1.5% from span-1 to span-2. CPH for smaller shrimp species declined whereas increased for commercial species. Expected catch for each year estimated by Schaefer production model (CEDA; r2=0.72) showed underexploitation during 2001 and 2004; optimum state of exploitation for four years during 2005, 2006, 2007 and 2009 and overexploitation for four years during 2002, 2003, 2008 and 2010. In terms of total fish landings, 2001 and 2002 showed underexploitation, optimum state during six years i.e., 2003, 2006, 2007, 2008, 2009 and 2010; while overexploitation during 2004 and 2005. Considering the exploitation rate of both penaeid shrimps and total fish, by sona boats, the study suggests restriction of fishing effort at the 2009-2010 level to ensure sustainability of the resources.
Determinants of credit default swaps implied ratings during the crisis: was sovereign risk mispriced?
Authors: Alberta Oliveira Maria , Santos Carlos
Published: July 2018

This paper addresses the question of whether sovereign risk pricing was related to macroeconomic fundamentals, between 2007 and 2015, in a sample of OECD countries. The authors argue that the conflicting evidence in the literature is due to poor methodology options. The researchers innovate by modelling sovereign credit default swaps implied ratings as our sovereign risk proxy, instead of spreads, avoiding common pitfalls. Furthermore, the authors improve the variable selection, model specification and the econometric procedures used. A panel ordered probit model is chosen, assuring robust inference. The authors relax the parallel lines assumption, allowing for rating-varying coefficients of explanatory variables. The result is the first congruent model of sovereign risk during the years of the financial crisis and of the Euro Area crisis. Fiscal space variables, economic activity indicators, variables pertaining to external imbalances, and contagion proxies are relevant, with effects matching theory priors. The scientists clarify conundrums in the previous literature, posed by lack of significance of some macro fundamentals and by puzzling signs of some estimated coefficients. Moreover, this is the first paper to estimate not only the global risk premium, but also the impact of changing risk aversion. The authors find no support for claims of sovereign risk mispricing during the sample period. The results allow relevant policy conclusions, namely concerning the validity of different fiscal consolidation paths in financially distressed countries.
Impact of climate change on water requirements and growth of potato in different climatic zones of Montenegro
Authors: Knežević Mirko , Zivotić Ljubomir , Čereković Nataša , Topalović Ana , Koković Nikola , Todorovic Mladen
Published: July 2018

The impact of climate change on potato cultivation in Montenegro was assessed. Three scenarios (A1B, A1Bs and A2) for 2001–2030, 2071–2100 and 2071–2100, respectively, were generated by a regional climate model and compared with the baseline period 1961–1990. The results indicated an increase of temperature during the summer season from 1.3 to 4.8 °C in the mountain region and from 1 to 3.4 °C in the coastal zone. The precipitation decreased between 5 and 50% depending on the scenario, region and season. The changes in temperature and precipitation influenced phenology, yield and water needs. The impact was more pronounced in the coastal areas than in the mountain regions. The growing season was shortened 13.6, 22.9 and 29.7 days for A1B, A1Bs and A2, respectively. The increase of irrigation requirement was 4.0, 19.5 and 7.3 mm for A1B, A1Bs and A2, respectively. For the baseline conditions, yield reduction under rainfed cultivation was lower than 30%. For A1B, A1Bs and A2 scenarios, yield reductions were 31.0 ± 8.2, 36.3 ± 11.6 and 34.1 ± 10.9%, respectively. Possible adaptation measures include shifting of production to the mountain (colder) areas and irrigation application. Rainfed cultivation remains a viable solution when the anticipation of sowing is adopted.
Организация психологического обеспечения деятельности по освобождению заложников в условиях совершения террористического акта
Authors: Марьин Михаил Иванович , Касперович Юлия Григорьевна
Published: July 2018

The structure and methods of work of Ministry of Internal Affairspsychological service during the counter-terrorist operations are analysedin the article. The authors designate the service’s aims, tasks, functions,and mutual relations with other organizations and departments, who takepart in the emergency consequences elimination.Psychological methods of work of the service are demonstrated withthe examples of elimination of tragic events consequences in 2004:explosion in Moscow Metro (February and August), capture of airliners(August), and terrorist act in Beslan (September). The work ofpsychological service of Ministry of Internal Affairs of Chechen Republic isworthy to be praised.The authors offer some methods for increasing the effectiveness ofthe system of psychological support of activity on prevention andliquidation of the terrorist acts consequences in the Russian Federation.
Рецензия на книгу Роберта Эммонса «Психология высших устремлений: мотивация и духовность личности»
Authors: журнал Российский ­ психологический ­
Published: July 2018

/
Частотная специфичность осцилляторов гамма ритма
Authors: Данилова Нина Николаевна
Published: July 2018

In this article, there is analysis of gamma-rhythm ’s issue, which provides foundation for appearance and wide expansion of the binding conception of different networks into united system via mechanism of gamma-rhythm synchronization. Author research own issue of activity’s synchronization with narrow band gamma oscillators, adjusted to a certain frequency under conditions which stimulate gamma-rhythm increase. New research technology of gamma-rhythm which gets more precise data about brain localization of gamma-rhythm dipoles because of their projection to individual brain homographic section.
Intervention and Observational Trials are Complementary in Metabolomics: Diabetes and the Oral Glucose Tolerance Test
Authors: Gonzalez-Dominguez Alvaro , Lechuga-Sancho Alfonso Maria , Gonzalez-Dominguez Raul
Published: July 2018

Observational experimental designs are usually employed in metabolomics to elucidate
pathological mechanisms underlying disease development and to discover candidate biomarkers for diagnosis.
However, intervention trials can also be a suitable starting point before performing a validation
study in lager epidemiological cohorts, with a great potential in personalized medicine to investigate
how different patients respond to similar stimuli. In the present work, we provide a review of the literature
on the application of metabolomics to investigate metabolic alterations associated with diabetes, the
diabetes predisposing state of insulin resistance and the oral glucose tolerance test as a case study to
demonstrate the complementarity of observational and interventional study designs.
A Novel Model for Predicting LncRNA-disease Associations based on the LncRNA-MiRNA-Disease Interactive Network
Authors: Wang Lei , Xuan Zhanwei , Zhou Shunxian , Kuang Linai , Pei Tingrui
Published: July 2018

Background:

Accumulating experimental studies have manifested that long-non-coding RNAs (lncRNAs) play an important part in various biological process. It has been shown that their alterations and dysregulations are closely related to many critical complex diseases.

Objective:

It is of great importance to develop effective computational models for predicting potential lncRNA-disease associations.

Method:

Based on the hypothesis that there would be potential associations between a lncRNA and a disease if both of them have associations with the same group of microRNAs, and similar diseases tend to be in close association with functionally similar lncRNAs. A novel method for calculating similarities of both lncRNAs and diseases is proposed, and then a novel prediction model LDLMD for inferring potential lncRNA-disease associations is proposed.

Results:

LDLMD can achieve an AUC of 0.8925 in the Leave-One-Out Cross Validation (LOOCV), which demonstrated that the newly proposed model LDLMD significantly outperforms previous state-of-the-art methods and could be a great addition to the biomedical research field.

Conclusion:

Here, we present a new method for predicting lncRNA-disease associations, moreover, the method of our present decrease the time and cost of biological experiments.
Use of Big Data and Machine Learning Methods in the Monitoring and Evaluation of Digital Health Programs in India: An Exploratory Protocol (Preprint)
Authors: Mohan Diwakar , Bashingwa Jean Juste Harrisson , Dane Pierre , Chamberlain Sara , Tiffin Nicki , Lefevre Amnesty
Published: July 2018

BACKGROUND

Digital health programs, which encompass the subsectors of health information technology, mobile health, electronic health, telehealth, and telemedicine, have the potential to generate “big data.”

OBJECTIVE

Our aim is to evaluate two digital health programs in India—the maternal mobile messaging service (Kilkari) and the mobile training resource for frontline health workers (Mobile Academy). We illustrate possible applications of machine learning for public health practitioners that can be applied to generate evidence on program effectiveness and improve implementation. Kilkari is an outbound service that delivers weekly gestational age–appropriate audio messages about pregnancy, childbirth, and childcare directly to families on their mobile phones, starting from the second trimester of pregnancy until the child is one year old. Mobile Academy is an Interactive Voice Response audio training course for accredited social health activists (ASHAs) in India.

METHODS

Study participants include pregnant and postpartum women (Kilkari) as well as frontline health workers (Mobile Academy) across 13 states in India. Data elements are drawn from system-generated databases used in the routine implementation of programs to provide users with health information. We explain the structure and elements of the extracted data and the proposed process for their linkage. We then outline the various steps to be undertaken to evaluate and select final algorithms for identifying gaps in data quality, poor user performance, predictors for call receipt, user listening levels, and linkages between early listening and continued engagement.

RESULTS

The project has obtained the necessary approvals for the use of data in accordance with global standards for handling personal data. The results are expected to be published in August/September 2019.

CONCLUSIONS

Rigorous evaluations of digital health programs are limited, and few have included applications of machine learning. By describing the steps to be undertaken in the application of machine learning approaches to the analysis of routine system-generated data, we aim to demystify the use of machine learning not only in evaluating digital health education programs but in improving their performance. Where articles on analysis offer an explanation of the final model selected, here we aim to emphasize the process, thereby illustrating to program implementors and evaluators with limited exposure to machine learning its relevance and potential use within the context of broader program implementation and evaluation.

INTERNATIONAL REGISTERED REPOR

DERR1-10.2196/11456
User-Centered Adaptation of an Existing Heart Failure Telemonitoring Program to Ensure Sustainability and Scalability: Qualitative Study (Preprint)
Authors: Ware Patrick , Ross Heather J , Cafazzo Joseph A , Laporte Audrey , Gordon Kayleigh , Seto Emily
Published: July 2018

BACKGROUND

Telemonitoring interventions for the management of heart failure have seen limited adoption in Canadian health systems, but isolated examples of telemonitoring programs do exist. An example of such a program was launched in a specialty heart failure clinic in Toronto, Canada, and a recent implementation evaluation concluded that reducing the cost of delivering the program is necessary to ensure its sustainability and scalability.

OBJECTIVE

The objectives of this study were to (1) understand which components of the telemonitoring program could be modified to reduce costs and adapted to other contexts while maintaining program fidelity and (2) describe the changes made to the telemonitoring program to enable its sustainability within the initial implementation site and scalability to other health organizations.

METHODS

Semistructured interviews probed the experiences of patients (n=23) and clinicians (n=8) involved in the telemonitoring program to identify opportunities for cost reduction and resource optimization. Ideas for adapting the program were informed by the interview results and prioritized based on (1) potential impact for sustainability and scalability, (2) feasibility, and (3) perceived risks to negatively impacting the program’s ability to yield desired health outcomes.

RESULTS

A total of 5 themes representing opportunities for cost reduction were discussed, including (1) Bring Your Own Device (BYOD), (2) technical support, (3) clinician role, (4) duration of enrollment, and (5) intensity of monitoring. The hardware used for the telemonitoring system and the modalities of providing technical support were found to be highly adaptable, which supported the decision to implement a BYOD model, whereby patients used their own smartphone, weight scale, and blood pressure cuff. Changes also included the development of a website aimed at reducing the burden on a technical support telehealth analyst. In addition, the interviews suggested that although it is important to have a clinician who is part of a patient’s circle of care monitoring telemonitoring alerts, the skill level and experience were moderately adaptable. Thus, a registered nurse was determined to be more cost-effective and was hired to replace the existing nurse practitioners in the frontline management of telemonitoring alerts and take over the technical support role from a telehealth analyst.

CONCLUSIONS

This study provides a user-centered example of how necessary cost-reduction actions can be taken to ensure the sustainability and scalability of telemonitoring programs. In addition, the findings offer insights into what components of a telemonitoring program can be safely adapted to ensure its integration in various clinical settings.
Circular Economy and Eco-Innovation Solutions for Low-Carbon Buildings in Cities: The Case of Kayseri
Authors: Sevindik Selman , Spataru Catalina
Published: July 2018

An analysis of eco-innovations solutions for efficient low carbon buildings through circular economy principles (reduce, reuse, recycle), that also consider economic and social indicators has been performed at the national (Turkey) and urban scale (Kayseri). The framework for the city of Kayseri and the implementation of the circular economy for construction chain were determined that the three enabler tools which are policies, funding and awareness and collaboration could help to implement circular city model in Turkey. Reducing energy intensity and understanding the factors that can influence this (such as urbanization and industrialisation) will help mitigate future climate changes, improve local air pollution and health.
Santa María de la Antigua del Darién, la primera ciudad española en Tierra Firme: una prospección arqueológica sistemática
Authors: Sarcina Alberto
Published: July 2018

En el año 1510 se fundó Santa María de la Antigua del Darién, la primera ciudad española en Tierra Firme. En el 2013, el ICANH inició un Plan de Manejo y Protección de este sitio. En la primera etapa los principales objetivos arqueológicos fueron identificar y delimitar el área de la ciudad y comprobar o refutar la hipótesis de si Bahía La Gloria fue el puerto de la ciudad. Las evidencias de prospecciones por pozos de sondeo fueron cruzadas con imágenes satelitales, análisis de suelos e investigaciones subacuáticas. Como resultado, por primera vez, podemos definir con certeza la ubicación y los límites de la ciudad y del pueblo Cueva junto al cual fue construida. La falta de evidencias de origen español, tanto en las investigaciones subacuáticas como en las prospecciones terrestres, reducen la posibilidad de que Bahía La Gloria fuera el antiguo puerto marítimo de la ciudad.
Entre La Violencia, la colonización y la adjudicación de reservas
Authors: Calle Alzate Laura
Published: July 2018

La historia del pueblo sikuani ha estado asociada a la incursión colonizadora y a la usurpación de sus tierras ancestrales, lo que ha causado la ruptura de lazos culturales y de identidad. Desde una perspectiva histórica y etnográfica, este artículo aborda dos momentos relacionados con el abandono forzado y el despojo del territorio sikuani. A partir de los relatos sobre el pasado y la memoria de los habitantes del resguardo Wacoyo, examino el periodo de La Violencia de los años cincuenta y de la adjudicación de reservas en 1960 y 1970, como momentos clave para explicar la constitución de la territorialidad sikuani actual y los sentidos y significados que los sikuanis del presente le otorgan al despojo territorial del pasado. El artículo valoriza y hace visibles los relatos indígenas y el despojo asociado.
Entre el asombro y el asco: el consumo de insectos en la cuenca amazónica. El caso del Rhynchophorus palmarum (Coleoptera Curculionidae)
Authors: Cartay Rafael
Published: July 2018

A partir de una exploración de campo en la Amazonía peruana y de una extensa revisión bibliográfica sobre los insectos comestibles, un tema poco estudiado por la academia sudamericana, este artículo aborda la importancia del consumo de insectos entre grupos indígenas de la cuenca amazónica, en particular, de la larva del coleóptero Rhynchophorus palmarum, como una fuente alternativa de proteína y grasa en la dieta alimentaria cotidiana. Describe, además, la actividad económica de recolección, el procesamiento culinario, las distintas formas y la dimensión simbólica del consumo de insectos.
ABUSO SEXUAL: FORMAÇÃO PROFISSIONAL, CONDIÇÕES DE ENFRENTAMENTO DA PROTEÇÃO SOCIAL ESPECIAL E O ADOECIMENTO DO PROFISSIONAL QUE ATUA NO ATENDIMENTO ÀS VÍTIMAS
Authors: Alcoforado Elizabeth da Silva
Published: July 2018

O presente artigo é fruto da tese de doutorado em sociologia/UFPB - O PODER NOS MUROS DO SILÊNCIO: abuso sexual, segredo e família, defendida em 2016.As vítimas de violência sexual nas unidades de saúde e de assistência são sempre acolhidas por uma equipe multidisciplinar. A multiplicidade de olhares para uma mesma questão – o abuso sexual – favorece a compreensão deste problema como multifacetado. Como pontuou Azevedo e Guerra (2007), a vítima de abuso sexual apresenta-se como uma síntese de comorbilidade, ou seja, a vítima nunca se apresenta apenas com uma única modalidade de violência, mas como uma síntese de modalidade de violência intrafamiliar que será revelada no contato e na escuta qualificada da equipe multidisciplinar. A revelação da violência sexual, mediante relato da vítima junto aos profissionais qualificados, possibilita também a exposição de toda uma dinâmica da violência doméstica. Neste sentido, a atuação em rede é um ponto crucial, visto que várias demandas se apresentam, requerendo com isso que o trabalho seja fortalecido entre os técnicos de atendimento direto, como também com a equipe de referência e contra referência. Trabalhar com a dor do outro não representa uma tarefa fácil para as equipes multidisciplinares no setor de saúde e assistência social. As dificuldades de operacionalizar as ações por limitações institucionais, de formação, de apoio e falta de capacitação adequada, muitas vezes, leva a própria equipe a buscar formas criativas para suportar o peso do cotidiano permeado por histórias de violências.
SERVIÇO SOCIAL BRASILEIRO: DA GÊNESE CONTRADITÓRIA ÀS ATUAIS POSSIBILIDADES ÉTICO-POLÍTICAS
Authors: Oliveira Leidiane Souza de
Published: July 2018

Decorridas quase duas décadas do século XXI, as particularidades brasileiras, enquanto país periférico no circuito do capital mundial, são evidenciadas pela acentuada desigualdade entre as classes, profunda crise política com escândalos de corrupção e desmonte das legislações que regulam a proteção social e os direitos trabalhistas, cujas implicações resvalam no cotidiano profissional de Assistentes Sociais nos mais distintos espaços em que se inserem. No auge de suas oito décadas, o Serviço Social brasileiro, marcado pela contradição histórica que lhe caracteriza: atender simultaneamente interesses de classes antagônicas, é conjunturalmente afetado enquanto profissão, pelas transformações societárias no processo de desenvolvimento das relações sociais capitalistas. Buscamos nesse artigo, com o uso de pesquisa bibliográfica, apontar as recentes contradições entre os limites postos no contexto histórico dos primeiros anos do presente século e as possibilidades organizativas de uma resistência coletiva, cujos fundamentos ético-políticos pilares do projeto profissional crítico articula-se às lutas sociais gerais, como caminho possível de uma nova ordem societária.