bluuebunny/crossref_metadata_2025 huggingface dataset:
FACTORS INFLUENCING ONLINE LEARNING ENGAGEMENT: INTERNATIONAL STUDENTS’ PERSPECTIVE AND THE ROLE OF INSTITUTIONAL SUPPORT
Authors: ABUBAKARI Mussa Saidi , NURKHAMID Nurkhamid , PRIYANTO Priyanto
Published: October 2022

The study was intended to model online learning engagement of international students studying in Indonesia to determine which factors affect learner engagement. A survey was conducted online, and 102 international students filled the questionnaire. Partial Least Squares-Structural Equation Modeling (PLS-SEM) technique was used for data analysis. The results show that the variables: university support (T = 2.881, P< 0.01), motivation (T = 3.411, P< 0.01), and personal innovativeness (T = 2.426, P< 0.05) were the significant predictors of international students’ engagement in online learning. Other variables like instructor interactivity, student-material interaction, student-student interactions, and self-regulated learning didn’t significantly affect learner engagement. The findings of this exploration can be used as empirical data for higher education institutions’ managers when developing support programs for international students during their studies in a destination country. Other findings’ implications and recommendations are discussed.
UNDERGRADUATES’ ATTITUDES TOWARDS DISTANCE EDUCATION AND PERCEPTIONS OF READINESS FOR E-LEARNING DURING THE COVID-19 PANDEMIC
Authors: KULOGLU M. Esad , YILDIZ Sevilay
Published: October 2022

The COVID-19 pandemic, which suddenly took the whole world under its influence, also radically affected the educational environments. This research aimed to examine the attitudes of undergraduates towards distance education, their perceptions of readiness for e-learning, and the relationship between these two variables during the COVID-19 pandemic, the effects of which are also felt in higher education. Thus, quantitative research paradigm and correlational design were used in the study. Data were collected online in two weeks via the Attitude Scale towards Distance Learning (ASDL) and E-Learning Readiness Self-Assessment Instrument (ERSI). Using the convenient sampling method, 1422 undergraduate students enrolled in a summer school program at a state university in Turkiye were included in the sample. The findings of the research indicate that the participants’ attitudes towards distance education are moderate, and their perceptions of readiness for e-learning are high-level during the COVID-19 pandemic. There is a moderate positive correlation between these two variables. There are also positive, moderate, or strong correlations between the ASDL and some subscales of the ERSI. The findings of the study provide useful information about the distance education carried out during the COVID-19 pandemic.
A SNAPSHOT OF FLIPPED INSTRUCTION IN ENGLISH LANGUAGE TEACHING IN TURKIYE: A SYSTEMATIC REVIEW
Authors: BALTACI Hasan Serif
Published: October 2022

This study aims to explore the trends and the perceived benefits and challenges of flipped language instruction regarding student achievement and attitudes in Turkiye. To that end, the databases, including Web of Science Core Collection, Scopus, Eric and DergiPark were reviewed, and a total of 20 articles were analyzed. Systematic review was utilized as the research methodology. The findings revealed that flipped instruction in ELT has gained importance since 2015 in Turkiye and has been gradually receiving more attention in research and practice. In the reviewed studies, the most employed research method turned out to be the mixed method, whilst the purely quantitative and qualitative studies were not abundant. It is seen that writing has been the most frequently researched language skill with respect to flipped instruction, whereas the other skills were not subject to investigation considerably. Furthermore, apart from language skills as the primary focus, the studies also concentrated on students’ perceptions, achievement, self-directed learning, attitudes, and classroom engagement. Finally, the reviewed studies illustrated the challenges and benefits of the flipped classroom in relation to students’ achievement and attitudes towards learning. In the light of the findings, implications for practice and recommendations for future research are provided.
TÜRKİYE’DE GENÇ İZLEYİCİLER, YOUTUBE KÜLTÜRÜ VE HAYRAN KAVRAMI
Authors: KESİCİ İpek
Published: October 2022

Günümüzde dijital teknolojiler ile gelişen dijital kültürlerin oluşumunu ve gündelik hayattaki yerini kavrayabilmek adına iletişim teknolojilerine izleyici ve kullanıcı perspektifinden yaklaşmak gerekir. Bu sebeple bu çalışmada genç izleyiciler kapsamında YouTuber’lara duyulan ilgi ve hayranlık analiz edilmiştir. Araştırma yöntemi olarak niteliksel yöntem tercih edilmiş ve 10-14 yaşları arasında toplamda 12 kişi ile derinlemesine mülakatlar gerçekleştirilmiştir. Çalışmada elde edilen bulgular arasında YouTuber hayranlığında en fazla öne çıkan kavramların ünlü olma, samimiyet, kurgusal içerikler, çocuksuluk ve erişim olduğu saptanmıştır. Katılımcıların, belirtilen kavramları dijital kültüre uygun olarak tekrar tanımladığı gözlemlenmiştir. Dijital hayran kültürü, geçmişteki eğilimlerden beslenen fakat kendisine içkin kavramlarıyla yeni bir kültür oluşturmuştur.
Exposure of the retina to subthreshold micro- and nanosecond laser at early stages of age-related macular degeneration
Authors: Gavrilova Natalia A. , Gadzhieva Nuria S. , Subbota Elena A.
Published: October 2022

At the moment, there are no effective methods of treatment for age-related macular degeneration at its early stages. The perspective of treatment for age-related macular degeneration may be a method using subthreshold laser radiation.
In the present review of literature, analysis is represented of using both subthreshold micro- and nanosecond laser radiation on the retina in intermediate AMD stage. Subthreshold diode micro-pulse laser exposure of the retina in AMD has proven to be a safe procedure that allows for the regression of macular drusen.
While some authors noted an improvement in visual functions and a decrease in the probability of developing choroidal neovascularization with such treatment, multicenter trials have not yet confirmed the effectiveness of micro-pulse therapy as a method to prevent the neovascular AMD development.
Subthreshold nanosecond laser impact on the retina is safe for the structures of the eye fundus, theoretically more selective stimulates the natural biological and regenerative potential in the pigment epithelium and neuroepithelium due to remodeling of extracellular matrix, restores the thickness of the Bruchs membrane and metabolism between external retinal layers and choriocapillaris.
Encouraging results have been achieved from the use of nanopulse therapy as a method of preventing the development of advanced stage AMD in the absence of reticular pseudodrusen, however, it seems premature to recommend this technology for widespread clinical use - further research is needed.
The prospects of invading in wide clinical practice of subthreshold nanosecond laser impact on the intermediate stage of AMD on the basis of the obtained clinical research results are encouraging (regression of drusen, preventing of AMD progression in absence of reticular pseudodrusen), but there is currently no evidence base. It is required to conduct further researches.
Ocular surface and the upper eyelid contour after surgical treatment of upper eyelid retraction in thyroid eye disease
Authors: Anikina Liliia K. , Astakhov Sergey Yu. , Potemkin Vitaliy  V. , Babaeva Shohida E. , Kostygina Serafima A.
Published: October 2022

BACKGROUND: Most of the thyroid eye disease (TED) patients have dry eye syndrome. Upper eyelid retraction (UER) is the most common TED symptom and one of dry eye causes. There are two groups of UER surgical treatment methods: transconjunctival and transcutaneous, which can influence on upper eyelid contour, tear film and ocular surface.
AIM: To evaluate the influence of different methods of UER surgery on upper eyelid contour and ocular surface.
MATERIALS AND METHODS: 12 patients (19 eyes) were included in the study. Visual acuity test, measurements of UER and palpebral fissure height, Shirmer 1 test, LIPCOF-test and tear break-up time test, Meibomian gland dysfunction staging, corneal and conjunctival fluorescein staining and determination of the ocular surface disease index (OSDI) were performed before surgery and 1 week, 1 and 3 months after. Patients were divided into two groups. Patients of group 1 had UER less than 4 mm and they underwent an upper tarsal muscle extirpation. Patients of group 2 had UER 4 mm and more and they underwent a recession of the levator palpebrae superioris muscle apouneurosis.
RESULTS: In all patients UER and the height of the palpebral fissure decreased 7 days after surgery and increased again after 3 months, and the dynamics of this change was more pronounced in group 2. There was one patient (both sides) with poor upper eyelid contour after surgery in both groups. BCVA and OSDI improved, while other parameters had a large scatter of data.
CONCLUSIONS: We have found that surgical treatment of UER caused by TED improves the contour of the eyelid, increases visual acuity and leads to a subjective improvement in the condition of the ocular surface.
Pathogenesis and treatment principles ocular damage by self-defense gas weapons
Authors: Kacherovich Polina A. , Kulikov Alexey  N. , Lapina Natalia V. , Bespalov Alexander Ya. , Krasnov Konstantin A. , Kharitonova Natalya N. , Troyanovskiy Roman L.
Published: October 2022

The article presents the pathogenetic mechanisms of eye damage by gas self-defense weapons in detail. We discuss the mechanisms of eye damage and structural changes of the tissues after gas-trauma. The causes of these changes and the main clinical manifestations accompanying them are analyzed. We analyzed the factors, influencing the development of dystrophic changes of the ocular surface in detail. The information on various techniques for self-assistance, mutual aid and earlier specific treatment of this injury was summarized. An aqueous solution of pediphene substance promising for use is considered, which has a number of pharmacological properties that fundamentally affect the pathogenetic mechanisms of gas-weapon trauma. Its effectiveness was shown in the experiment in comparison with the control group without treatment and the group using the combined drug-dexamethasone in combination with an antibiotic.
Femtoassisted posterior lamellar keratoplasty in bullous keratopathy of stage IV–V (clinical application experience)
Authors: Tereshchenko Alexander  V. , Demyanchenko Sergey K. , Trifanenkova Yana M. , Golubeva Yulia Yu. , Vishnyakova Ekaterina N.
Published: October 2022

BACKGROUND: Bullous keratopathy is a chronic edema of the cornea, accompanied by a significant visual acuity loss and pain. The cause of bullous keratopathy is a pathological irreversible decrease in the number of endothelial cells, in which the endothelial layer cannot perform its main barrier and pumping functions.
AIM: To evaluate the reproducibility and functional results of femto-assisted posterior lamellar keratoplasty using intraoperative OCT at the stage IVV of bullous keratopathy.
MATERIALS AND METHODS: The study was conducted on 23 eyes of 23 patients diagnosed with stage IVV of bullous keratopathy. The mean age of patients was 69 12 years, there were 14 male patients and 9 female patients. Before surgery, light perception with correct light projection was recorded in 15 cases, in 5 cases the count of fingers at the face (0.005), in 3 cases visual acuity was 0.01. The central corneal thickness varied from 981 m to 1960 m and averaged 1008 96 m. Femto LDV Z8 femtosecond laser (Ziemer, Switzerland) was used to form an endothelial graft. All surgeries were performed using the Hi-R Neo 900 operating microscope with an integrated third-generation OCT module (Haag-Streit Surgical, Germany).
RESULTS: No intraoperative complications were noted. The presence of objective control in the form of intraoperative OCT made it possible in all cases to clearly differentiate stromal and endothelial surfaces of the posterior layered graft located in the anterior chamber of the eye. The postoperative course was standard for posterior lamellar keratoplasty, accompanied by resorption of corneal edema with restoration of its transparency. The normalization of corneal thickness was noted by 1 month after surgery, and the restoration of corneal optical properties was noted by 36 months and was accompanied by gradual increase in visual acuity. Corrected visual acuity by 1 month was 0.05 0.03, by 3, 6, 12 months 0.1 0.05, 0.15 0.05 and 0.15 0.04, respectively. By 12 months after surgery, the central corneal thickness was 596 42 m, the thickness of the ultrathin graft tended to decrease somewhat to 67 8 m, the loss of endothelial cells was 59.3%. Endothelial graft survival was achieved in 82.6% of cases.
CONCLUSIONS: The use of intraoperative OCT allows expanding the indications for posterior lamellar keratoplasty in bullous keratopathy, including the stage IVV of the disease.
Peripapillary retinoschisis associated with glaucomatous optic neuropathy (clinical cases)
Authors: Doktorova Taisiia A. , Suetov Aleksei A. , Boiko Ernest V.
Published: October 2022

Peripapillary retinoschisis is a rare condition and is detected more often in patients with glaucoma or glaucoma suspects, while data on the pathophysiological mechanisms of development and the effect on the course of glaucoma are limited. The article presents two clinical cases of unilateral peripapillary retinoschisis detected accidentally during a routine examination of patients with glaucoma.
Ciclosporin use for prevention of pterygium recurrence
Authors: Bochkareva Anna N. , Kolenko Oleg V.  , Egorov Victor V. , Smoliakova Galina P. , Banshchikov Pavel A.
Published: October 2022

BACKGROUND: Despite the development of new methods for treatment of pterygium, the frequency of its recurrence ranges from 5 to 89%.
AIM: Was to evaluate the effectiveness of ciclosporin for prevention of pterygium recurrence.
MATERIALS AND METHODS: Under follow-up, there were 104 patients operated for pterygium, of which 26 had a high risk of recurrence, they were divided into 2 groups: the 1st group 13 patients received 0.05% ciclosporin in addition to basic therapy; the 2nd group 13 patients receiving only basic therapy. Patients of studied groups were under dynamic observation for 1 year.
RESULTS: After 3 months, all patients of the 1st group showed normalization of the osmolarity of the lacrimal fluid (OLF) and the ocular surface disease index (OSDI). In patients of the 2nd group, elevated values of OLF and OSDI remained characterizing the persistence of an inflammatory reaction signs and a high risk of the disease recurrence, as well as the formation of a hypertrophic scar in 38.5% of cases. In one year after surgery, 3 patients of group 2 had a recurrent pterygium, which required surgical retreatment.
CONCLUSIONS: We obtained results showing a positive effect of ciclosporin use on dynamics of inflammatory reactions of the ocular surface in postoperative period, which made it possible to prevent pterygium recurrence after its surgical treatment in patients with high risk of recurrence.
Transplantation of the oral mucosa epithelial layer in the treatment of corneal defects with limbal stem cell deficiency
Authors: Сhentsova Ekaterina V. , Borovkova Natalia V. , Tselaya Tatyana V. , Storozheva Maya V. , Ponomarev Ivan N. , Makarov Maxim S.
Published: October 2022

BACKGROUND: Corneal epithelialization occurs due to proliferation and differentiation of limbal stem epithelial cells. Death of these cells or damage of its microenvironment leads to limbal stem cell deficiency. In bilateral total limbal damage (both eyes), autologues limbal stem cells transplantation becomes impossible. So, it is revalent to find new sources of autologous progenitor cells. One of such sources are buccal cells from cheek mucosa.
AIM: To study the reparative effect of buccal cells in oral mucosa autologous epithelial layer in a mechanical limbal stem cell deficiency model.
MATERIALS AND METHODS: The study was conducted on 7 Chinchilla rabbits (14 eyes). At the first stage, rabbits underwent bilateral total limbectomy and mechanical de-epithelialization of the cornea resulted in fibrovascular pannus development. Then, a full-layer flap of the cheek mucosa measuring 5 5 mm was taken, and epithelial layer was separated by 0.5% dispase solution. After superficial keratectomy to transparent layers, a layer of buccal epithelium was placed to the cornea and covered with a soft contact lens. In controls soft contact lens, was placed on the cornea. Temporary tarsorrhaphy was performed for 5 days. In the postoperative period, the area of the deepithelized surface, neovascularization and corneal transparency were evaluated.
RESULTS: On the 7th30th day, a reduction of erosion was noted in experimental and control eyes, but the dynamics of recovery processes did not significantly differ. On day 60, the area of erosion in the experimental eyes was significantly less than in the control (p = 0.038). Recurrence of erosion was noted in 4 control and 3 experimental eyes.
CONCLUSIONS: In our model of limbal stem cell deficiency, the use of a buccal epithelium layer did not reveal a pronounced reparative effect.
Comparative evaluation of the results of phacoemulsification using domestic and foreign viscoelastics
Authors: Dzhaliashvili Georgiy Z. , Farikova Elmaz E.
Published: October 2022

BACKGROUND: Phacoemulsification, being the safest technique, is the golden standard of cataract surgery worldwide. However, as any surgery, it is accompanied by inevitable damage to intraocular structures. The most prevalent among them is the loss of corneal endothelial cells. In order to prevent these complications, various viscoelastics with particular features and characteristics are widely used.

AIM: To compare the anatomical and functional state of ocular structures after standard phacoemulsification with monofocal posterior chamber intraocular lens (IOL) implantation using domestic (Kogevisc and Adgevisc) and foreign (Viscoat and Amvisc Plus) viscoelastics.

MATERIALS AND METHODS: 60 cataract patients (60 eyes) were included in the clinical study, which were divided into two equal groups. In the first group (30 patients, 30 eyes), Adgevisc and Kogevisc (Solofarm, Russia) were used during the procedure. The mean age of the patients was 66 11 years. In the second group (30 patients, 30 eyes), Viscoat (Alcon) and Amvisc Plus (BauschLomb) were used. The mean age of the patients was 69.03 10.44 years. All patients underwent phacoemulsification with the implantation of the AcrySof IOL (model SA60AT, Alcon) according to the standard technique. Visual acuity, IOP level, CCT, corneal endothelial cell density were assessed. All studies were performed before surgery, the next day, 7 days and 1 month after surgery.

RESULTS: In patients of the second group, on the 1st (p 0.05) and 7th day (p 0.01) after surgery, a statistically significant increase in IOP was revealed compared to the first group. The central cornea thickness in the early postoperative period was higher in patients of the second group, however, it was not statistically significant. The loss of corneal endothelial cells 1 month after surgery was 8.5 7.0% (p 0.01) in the first group and 6.6 6.4% in the second group (p 0.01). The mean value of endothelial cell loss in patients of the first group was higher, however, it was not statistically significant. The best corrected visual acuity in both groups at all stages of follow-up after surgery (days 1, 7 and 30) was comparable, there was no significant difference between the groups.

CONCLUSIONS: The clinical efficacy of domestic adhesive and cohesive viscoelastics Adgevisc and Kogevisc (Solofarm, Russia) in phacoemulsification using the soft-shell technique is comparable to the foreign analogues Viscoat (Alcon) and Amvisc Plus (Bausch Lomb), which is confirmed by the absence of statistically significant differences in the studied parameters of the postoperative state of ocular structures and explained by their similar composition, molecular weight and viscosity.
The creation of a corneal incision with a femtosecond laser
Authors: Nizametdinova Yulduz Sh. , Takhtaev Yuri V.
Published: October 2022

BACKGROUND: The cutting action of a femtosecond laser (FS-laser) on the corneal tissue is performed using a photodestructive effect. FS-laser technology is used in many different areas of corneal surgery, and studying this effect is an actual issue.
AIM: To evaluate the surface of the corneal incision created by a FS-laser (experimental study).
MATERIALS AND METHODS: 20 porcine eyes were divided into two groups (FS-laser and keratome). The corneal tissue surface in the area of contact between two lips of the incision was visualized by electron microscopy.
RESULTS: In all cases, we received a full-thickness incisions through the cornea. Images obtained by electron microscopy showed regular surface, no signs of thermal or mechanical damage to the corneal structure.
CONCLUSIONS: The FS-laser is used as a microscopic scalpel in surgery. The precision cutting process is performed by mechanical forces generated by photodestruction by expanding cavitation bubbles.
A preliminary evaluation of a low-cost multispectral sensor for non-destructive evaluation of olive fruits’ fat content
Authors: Aquino Arturo , Noguera Miguel , Millan Borja , Mejías Andrés , Ponce Juan Manuel , Andújar José Manuel
Published: October 2022

This study presents a preliminary evaluation of a low-cost multispectral device for the non-destructive assessment of olive fruits’ fat content. The developed device integrates a multispectral sensor, with a spectral response of 18 channels falling in a range from 410 to 940 nm, a calibrated light source, and a programmable board, in a ‘gun’-shaped device whose trigger activates sample reading. The device was used to measure 50 intact olive samples, which were subsequently chemically analysed to determine their actual fat content. Then, the multispectral readings from the 18 channels were used as input variables to train a neural network, using the actual fat content registers as reference data. The measured results, in terms of root-mean-square-error and coefficient of determination, shows promising capabilities of the developed low-cost device in the prediction of fat content of intact olives, what stands up for further development and experimentation.
Modelado dinámico del ph en reactores raceway con redes neuronales
Authors: Otálora Pablo , Guzman Jose Luis , Gil Juan Diego , Berenguel Manuel , Acien Gabriel
Published: October 2022

Este trabajo se centra en el desarrollo de modelos de red neuronal para predicción de pH en fotobiorreactores raceway. Se han obtenido modelos capaces de predecir el valor del pH con un tiempo de muestreo de un minuto y un horizonte de predicción de hasta un día, para fotobiorreactores de aguas residuales o limpias. Los modelos emplean datos relativos a las condiciones climáticas y la operación del reactor. Los resultados obtenidos validan el uso de estas técnicas para el modelado de procesos biológicos, proporcionando modelos precisos, sencillos y de rápida ejecución.
Estrategias de modelado simplificadas de una máquina de absorción alimentada por energía solar para controladores basados en modelo
Authors: Pataro Igor M. L. , Gil Vergel Juan Diego , Domingo Álvarez José , Guzmán José-Luis , Berenguel Manuel
Published: October 2022

Las máquinas de absorción, a pesar de ser soluciones prometedoras para los sistemas de refrigeración de edificios, tienen un principio de funcionamiento no trivial, y los modelos estudiados suelen ser complejos, con un alto costo computacional y requieren la medición de muchas variables o condiciones específicas de operación. Por ello, con el objetivo de desarrollar modelos adecuados para el control automático, este trabajo propone la formulación de modelos simplificados que puedan representar adecuadamente el comportamiento de una máquina de absorción. En concreto, se estudia un modelo de parámetros concentrados basado en un balance energético, un modelo Auto-Regresivo con variables exógenas (ARX), y un modelo no lineal ARX (NARX) para proporcionar una solución simple y eficiente para estimar la temperatura de salida de los diferentes elementos de una máquina de absorción: generador, evaporador y condensador. El sistema estudiado es la instalación solar térmica del edificio CIESOL, situada en la Universidad de Almería, España. Los resultados han demostrado que todos los modelos propuestos estiman satisfactoriamente las salidas de la máquina de absorción, siendo el NARX el que ha conseguido los mejores resultados en términos de índices de error. Sin embargo, el modelo de primeros principios tiene el mejor compromiso entre rendimiento de error y coste computacional, presentando un tiempo de cómputo casi 100 veces menor al resto durante la validación.
Desarrollo de gemelo digital de un alimentador de bandejas e integración en entorno de realidad virtual
Authors: Ridao Olivar Miguel Ángel , Gómez Jiménez Javier , Castaño Fernando , Escaño Juan Manuel
Published: October 2022

En el presente artículo se tiene como objetivo principal la elaboración del gemelo digital del alimentador de bandejas presentes en una célula de fabricación flexible, la cual se encuentra ubicada en los laboratorios del departamento de Ingeniería de Automática y Sistemas de la Universidad de Sevilla. Además, dicho gemelo digital se integra dentro de un sistema de realidad virtual, el cual permite interactuar con todos los elementos presentes en la célula de fabricación flexible, para su automatización y supervisión.
Assessment of serum MMP-9, TIMP-1 levels and MMP-9/TIMP-1 ratio in migraine patients with and without aura
Authors: Karademir Fazilet , Ozturk Musa , Altunkaynak Yavuz , Doventas Yasemin , Mutluay Belgin , Basoglu Koseahmet Fulya , Baybas Sevim
Published: October 2022

Matrix metalloproteinases (MMP) are the enzymes responsible for proteolytic ac­tivity of extracellular matrix proteins. Tissue inhibitors of metalloproteinases (TIMPs) are their endogenous inhibitors. MMP-9 acts on the basal membrane of cerebellar epithe­lium and is antagonized by TIMP-1. MMP-9/TIMP-1 ratio exhibits the net activity of MMP-9. These enzymes are thought to have a role in migraine physio­pathogenesis. Total of 50 treatment-naive migraine patients (25 with aura and 25 without aura) with no other diseases, were included. 25 healthy control subjects of cor­responding age and gender were enrolled. For MMP-9 and TIMP-1 analysis, one serum sample from control group and two samples from patients were collected (during headache and headache-free periods). The enzyme levels were quantitatively analyzed by competitive ELISA method. Duration and severity of the pain and duration of the disease were recorded. There was no significant difference in MMP-9 levels between patient and control groups during headache and headache-free periods (p: 0,746, p: 0,243). TIMP-1 levels were significantly lower and MMP-9/TIMP ratios were higher comparing with the control group (p: 0.001). Positive correlation was obtained between the duration of pain and MMP-9 levels in the headache-free period for both patient groups (p<0.05). There was also a positive correlation between MMP-9/TIMP-1 ratio and severity of pain (p<0.05). In our study, low TIMP-1 levels of patients in both headache and headache-free periods suggest that disturbance of proteolytic protection has a role in neuro-inflammation and pain in migraine. Therefore, these enzymes could be potential targets in migraine therapies.
Relation between maternal vitamin D level and in vitro-fertilization laboratory outcome in normal responding patients 35 years old or less
Authors: Bahgat Nagwan Ahmed
Published: October 2022

Background: Vitamin D relation to pregnancy outcome have been extensively studied and proved, but the relation between the vitamin D and fertility and fertility treatment especially in vitro-fertilization still a matter of debate.Methods: A retrospective cohort study in large IVF center in Abu Dhabi, UAE involved young normal responding patients aged 35 years old or less attending the clinic for IVF treatment. Patient were divided in to three groups according to the serum level of vitamin D. the IVF laboratory outcome was calculated and compared in the three groups.Results: We found that the prevalence of vitamin D in patients seeking fertility treatment especially IVF was significantly high. But on the other hand, and after analysing the results of the cycles laboratory out come in the three groups, we found that no significant difference that could be attributed to maternal level of vitamin D.Conclusions: The prevalence of vitamin D deficiency and insufficiency in infertile patients is significantly high but no significant effect of vitamin D deficiency on the IVF laboratory outcome.
Management of ureterovaginal fistula: a retrospective study
Authors: Sharma Divya , Chaudhary Ranjit
Published: October 2022

Background: Ureterovaginal fistulae are a rare but extremely serious complication of gynaecologic surgery. The objective of this study is to evaluate the feasibility and outcome of endourology in the management of ureterovaginal fistulae.Methods: Retrospective study from August 2018 to April 2022 comprising 18 consecutive cases. Patients ranged from 25-45 years, most common preceding gynaecological intervention was total abdominal hysterectomy, most common presenting complaint was urinary leak. All patients in which the imaging studies showed the ureter communicating with the urinary bladder were taken up for primary stenting. Rest of the cases were subjected to a urinary diversion by percutaneous nephrostomy.Results: 12 cases had fistula on right and 6 on left side. Imaging studies showed communication in 12 cases in which primary retrograde stenting was attempted. We were successful in 8 cases.  In remaining 10 cases percutaneous nephrostomy was done. In the 10 cases of urinary diversion, antegrade stenting could be done in 3 cases. 2 out of these did not show any ureteric communication in the initial imaging studies. Overall, 11/18 cases (61.1%) could be stented, rest 7 cases were managed by ureteric reimplantation.Conclusions: Primary retrograde stenting should be considered the primary mode of intervention in all cases of ureterovaginal fistula where imaging studies show a ureteric communication with the bladder. When it is not possible or when imaging studies fail to demonstrate a communication, achieve a urinary diversion by nephrostomy and reassess after 2 weeks. All cases managed by endoscopic approach must be followed up after stent removal.
Real-world use and acceptance of biosimilar rituximab in oncology practice in India
Authors: Bunger Deepak , Rajani Anil , Patel Lav , Sharma Shreekant
Published: October 2022

Background: To describe the treatment patterns, patient characteristics and usage pattern of biosimilar rituximab for the treatment of Non-Hodgkin lymphomas (NHL) in India.Methods: This real-world, retrospective, analysis included adult patients receiving biosimilar rituximab between April 2021 and March 2022.Results: A total of 750 patients with NHL who received biosimilar rituximab were included. The most common indications reported in this analysis were diffuse large cell B-cell lymphoma [DLBCL, 64.5% (n=484)], follicular lymphoma, [FL, 23.7% (n=178)], and mantle cell lymphoma [MCL, 5.3% (n=40)]; other subtypes constituted 6.4% of the patients (n=48). The mean age of patients among DLBCL, FL and MCL was 65.5, 55.3 and 57 years, respectively. Across the lymphomas, >90% of the patients received R-chemo as first-line therapy. R-CHOP was the most common regimen across indications.Conclusions: Biosimilar rituximab-based chemotherapy is being adopted in real‑world clinical practice in India for the management of patients with B-cell NHL including DLBCL, FL, MCL and other lymphomas.
Multiple stab incision technique to prevent postoperative acute compartment syndrome of leg in proximal and segmental fracture tibia and fibula: a prospective study
Authors: Naik K. Parthasarathi , S. Shankarlinga , Kyavater Basavaraj S. , M. Prashanthkumar
Published: October 2022

The objective is to study the effectiveness of Multiple stab incision technique in preventing acute compartment syndrome (ACS) in proximal and segmental fractures of both bones (Tibia and fibula) in leg. This study is prospective done at K. S. Hospital Koppal, Karnataka spanning for a period of one year (April 2020 to April 2021). A total of 20 patients of both genders aged 20-60 years were included in the study. Multiple stab incision technique was performed in patients after fixation of Tibia by either closed nailing or MIPPO plating. This procedure was done under spinal anesthesia. Multiple stab incision technique significantly decreased the chances of post-op ACS in proximal and segmental fractures of both bones (tibia and fibula) in leg. Multiple stab incision technique is help full in preventing developing compartment syndrome.

 
 
Improving level measurement techniques and measurement accuracy in vehicle fuel tanks
Authors: ATALAY Öner , BELLİ Buse , SEZGİN Oğuz
Published: October 2022

Measuring the level and accurate transmission of the amount of fuel in vehicle fuel tanks are important in many ways. In vehicle warehouse designs, very different geometric shapes are encountered. Vehicle geometry and equipment placement cause warehouses to be produced in very different geometries. It is very important that information about the amount of fuel is transmitted to the driver in the most accurate way so that the driving safety and the car can travel safe distances. Shaking the fuel in the tank on a flat road, slope or off-road conditions may affect the display of the correct amount of fuel. In the study, the maximum and minimum production tolerance and geometry of the vehicle tanks, known as the mathematical model, the turbulence caused by acceleration of the float fuel measurement system in contact with the liquid placed in the tank, as well as the accuracy of the Up/Down movement of the level measurement float and the measurement of the fuel level as a result of the turbulence, were examined. The study focused on the oscillation of the measuring part on the float and the preventive geometries.
An emission reduction method in liquid hydrogen powered fuel cell vehicles
Authors: UĞURLU Adem
Published: October 2022

An emission reduction method has been analyzed for Liquid Hydrogen (LH2) powered Fuel Cell Vehicles (FCVs) using GREET software in this study. In the analysis, cooling rates and Coefficient of Performance (COP) values of the proposed system have been calculated for FCVs that considered. Average reductions of the years 2010, 2020, 2030, 2040, and 2050 in emissions for the use of Auxiliary Air Condition (AAC) system in the FCVs are analyzed in g/year for Volatile Organic Compounds (VOC), Carbon Monoxide (CO), Nitrogen Oxides (NOx), Particulate Matters (PM10 & PM2.5), and Sulfur Oxides (SOx). Average reduction in Carbon Dioxide (CO2) emission is calculated and given in kg/year. All the emissions decrease in significant proportions due to the reduction in fuel consumption by less usage of the main AC system of the vehicles.
Effects of fly ash introduction on friction and wear characteristics of brake pads
Authors: YILMAZ Ali Can
Published: October 2022

Fly ash is a waste matter generally emitted abundantly from chimneys of the production facilities and should mostly be recycled. In this context, this study reveals the tribological effects of fly ash on brake pad components by doping the fly ash in basic brake pad matrix with various weight fractions of 30% (S30), 35% (S35) and 40% (S40) by reducing aluminum powder in the pad matrix. According to the results, as the fly ash concentration increases in the matrix, density and hardness of the structure were prone to decrease to an extent. Water immersion technique was used to determine density values and specially modified pin-on-disc tribotester was utilized to measure coefficient of friction (CF) and specific wear rate (SWR) values between brake pad samples and the cast iron rotating disc. Among prepared samples, maximum average reduction in density and hardness were observed to be by 3.97% and 10.67%, respectively. S30 depicted the minimum CF of 0.32 and maximum CF of 0.43 was performed by S40. Maximum specific wear rate was observed for S40 subtending to an increase of 8.67% from that of S30 to S40. Results showed that, though higher escalation in CF as the fly ash fraction elevates in the matrix, wear rates did not show a dramatic increase which is an indication of effectiveness of fly ash in brake pads in terms of braking performance and long term durability.
Current Approach to Genetic Causes of Female Infertility and Genetic Counseling
Authors: SHIRINOVA Nıgar , YALÇIN Fatma Zehra , TUĞ BOZDOĞAN Sevcan
Published: October 2022

Infertility is a disease of the male or female reproductive system and is defined as the inability to achieve pregnancy after 12 months or more of regular and unprotected sexual intercourse. Data shows that more than 186 million people worldwide are infertile. About 10% of the women of reproductive age are unable to conceive or maintain a pregnancy. In this study, the causes of female infertility were reviewed under several headings and the importance of genetic counseling in infertility was also mentioned. There are many different causes of female infertility, including both genetic and non-genetic causes. In this review, current developments and approaches in the genetic etiology of female infertility were reviewed under six main headings, chromosomal abnormalities, female genital system disorders, hypogonadotropic hypogonadism, primary ovarian failure, polycystic ovary syndrome, and gonadal dysgenesis. Also, the role of genetic counseling in these diseases was discussed. The aim of genetic counseling is to inform people with a hereditary disease or at high risk of carrying it about the course of the disease and treatment methods, and also to guide future generations and family members about their risks. After all tests and examinations, genetic counseling has a very important place in reproductive health.
Current Approach to Genetic Causes of Male Infertility and Genetic Counseling
Authors: BEREKETOĞLU Muhammed Burak , ABDULLAYEV Rashad , TUĞ BOZDOĞAN Sevcan
Published: October 2022

Generally, infertility is defined as the inability of couples who have had unprotected and regular intercourse for at least 12 months or longer to conceive naturally. When all societies in the world are examined, infertility is an important health problem affecting approximately 48 million couples, and it also has socio-cultural, economic, and psychological effects. While 8-12% of reproductive age couples have infertility problems, when gender-related reasons are examined, 20-30% of these reasons are male, 20-30% are female, and 25-40% are together with couples. While the etiology of 60% of male infertility causes has not been clarified yet, congenital urogenital anomalies are the most common causes, and genetic causes are the second most common cause among the known causes. While investigating genetic etiology in patients, chromosomal anomalies and Y microdeletions are at the forefront; however, the importance of monogenic causes has increased as some known genes have been associated with infertility because of familial segregation studies and the whole exome analyses with the development of new generation sequencing technologies. In this review, genetic causes of male infertility, diagnosis, and treatment approaches for genetic causes were examined by the current literature, and the importance of providing the proper genetic counseling to infertility patients was mentioned.
Jednostka i historia w myśli Rousseau i Kanta
Authors: Pieniążek Paweł
Published: October 2022

Artykuł przedstawia Rousseau i Kanta wizje historii w perspektywie zależności tej drugiej od pierwszej. Przede wszystkim skupia się na ukazaniu ich wewnętrznych trudności  i wewnętrznych napięć, zdecydowanie więcej miejsca poświęcając filozofii historii Kanta. Koncepcję tę ujmuje jako zwieńczenie teleologicznej struktury rozumu ludzkiego, nadając jej status praktyczno-moralnej fikcji i odrzucając jej wykładnię teoretyczno-naturalistyczną. Następnie analizowane są trudności odnoszące się do wykładni moralnej. Analiza ta prowadzi do tezy, że właśnie pod ich ciężarem moralnie rozumiana historiozofia Kanta faktycznie załamuje się, nie będąc w stanie znieść nieusuwalnego napięcia między porządkami moralnym i legalnym historii i ostatecznie kryjącego się za nim napięcia między jednostką i historią; tkwiło ono więc w samych moralnych podstawach tej ostatniej.
Zagadnienie „zwrotu” w myśli Heideggera w kontekście dziejowości bycia
Authors: Murzicz Paweł
Published: October 2022

Artykuł dotyczy zagadnienia „zwrotu”(Kehre) w myśli Martina Heideggera. Pokazuję i uzasadniam, że postawione w Byciu i czasie pytanie o bycie z pozycji bytu wyróżnionego, jakim jest Dasein, doprowadziło do uprzedmiotowienia bycia powielając, a nie przezwyciężając, dotychczasowy, według Heideggera metafizyczny, sposób myślenia. Zwrot w myśli Heideggera polega na tym, że próbuje on uniezależnić bycie od człowieka, tj. próbuje wyjść poza transcendentalny i subiektywistyczny punkt widzenia Dasein poprzez umieszczenie dziejowości Dasein na tle dziejowości samego bycia. To nie Dasein projektuje bycie, lecz przeciwnie, bycie projektuje rozumienie dla Dasein.

W tym kontekście pokazuję, że postulowane przez Heideggera myślenie bycia przybiera postać myślenia samego procesu istoczenia się dziejowych wykładni bycia.
Apofatyka w fenomenologicznych rozważaniach o sztuce
Authors: Krawiec Andrzej
Published: October 2022

W fenomenologii coraz częściej obserwujemy zainteresowanie filozofów wczesną myślą chrześcijańską – w tym apofatyką – co nie pozostaje bez wpływu na pojmowanie roli i znaczenia sztuki. „Niewidzialność” w sztuce oraz objawienie Boga poprzez dzieło artystyczne stanowi tajemnicę, wobec której tradycyjne modele estetyki filozoficznej nie znajdują w pełni satysfakcjonujących wyjaśnień. Teologia negatywna – wraz z kluczową dla niej drogą apofatyczną – wnosi do współczesnych debat estetycznych nową perspektywę rozumienia dzieła sztuki, a jej „redukcyjne” zastosowanie odnajdujemy zwłaszcza w teorii ikony. Analiza ikony dokonana przez Pawła Florenskiego w wielu punktach wykazuje zbieżność z kategorią „fenomenu przesyconego” Jeana-Luca Mariona, a redukcja henologiczna Henry’ego Duméry’ego — uzupełniająca i zarazem przekraczająca redukcje Edmunda Husserla — rozszerza horyzont „niewidzialnego” wymiaru sztuki o relację, jaką duch (inteligibilność) nawiązuje z Transcendencją. W niniejszym artykule wskazuję na spójność współczesnej refleksji fenomenologicznej z wczesnochrześcijańską apofatyką oraz teorią ikony, a także stawiam pytania o zasadność i przydatność tak skonstruowanej koncepcji estetyczno-teologicznej jako ogólnej filozoficznej teorii sztuki.
Spór o Filozofię hermeneutyczną [Włodzimierz Lorenc, "Filozofia hermeneutyczna. Inspiracje, klasycy, radykalizacje", Wydawnictwa Uniwersytetu Warszawskiego, Warszawa 2019]
Authors: Błaszczyk Marek
Published: October 2022

Praca stanowi krytyczne omówienie książki Włodzimierza Lorenca zatytułowanej Filozofia hermeneutyczna. Inspiracje, klasycy, radykalizacje (Wydawnictwa Uniwersytetu Warszawskiego, Warszawa 2019). Celem naszym jest, po pierwsze, przybliżenie zasadniczych tez stawianych przez Autora; po wtóre natomiast – zaproszenie do namysłu nad fenomenem filozofii hermeneutycznej oraz jej miejscem we współczesnej myśli filozoficznej.
Umiarkowana obrona sceptycyzmu
Authors: Walicki Jakub
Published: October 2022

Artykuł stanowi próbę ukazania wiarygodności filozofii sceptycznej oraz jej ścisłego związku z mądrością. Objaśniam w nim podstawowe założenia sceptycyzmu, które staram się następnie zrewidować w kontekście kilku nowoczesnych „tropów sceptycznych” (retoryczny charakter wszelkiej argumentacji, gry językowe L. Wittgensteina, hermeneutyczna koncepcja wiedzy). Uwzględniając najczęściej spotykane zarzuty w stosunku do filozofii sceptycznej, objaśniam ich ograniczenia, powołując się na uwagi Sekstusa Empiryka. W ostatniej części artykułu ukazuję sceptycyzm jako pewien sposób bycia, który posiada istotne walory moralne.
Myśl polityczna Jacka Kuronia w perspektywie republikańskiej
Authors: Miksa Joanna
Published: October 2022

W artykule przedstawiam propozycję analizy myśli Jacka Kuronia w perspektywie republikańskiej. Wykorzystuję przy tym pojęcie przestrzeni wspólnej w wersji zaproponowanej przez Hannę Arendt oraz pojęcia podstawowe dla współczesnego republikanizmu w wersji zaproponowanej przez Philipa Pettita. Podstawowe tematy i pojęcia obecne w filozofii Pettita są obecne także w myśli Kuronia, w szczególności przekonanie o potrzebie aktywnego uczestnictwa obywateli w życiu publicznym. Jako polityk aktywny Kuroń brał udział w budowaniu instytucji państwowych po 1989 roku, z wprowadzeniem modelu gospodarki wolnorynkowej włącznie. Zmiany te przełożyły się na pojawienie się dramatycznie wysokiego poziomu bezrobocia. W myśli politycznej Kuronia można znaleźć uwagi i propozycje rozwiązań tego problemu, które można zinterpretować jako zgodne z duchem republikanizmu.
Estetyka afektu. Video-art Billa Violi
Authors: Taczkowska Kalina
Published: October 2022

Celem pracy jest omówienie wybranych prac Billa Violi odznaczających się najbardziej afektywną treścią po to, by na ich podstawie uzyskać wgląd w swoistość sztuki video jako gatunku artystycznego. W pracy zostaje postawiona teza, że tym, co odróżnia video-art od innych form sztuki, jest jego afektywny potencjał.
Heterotopy of the hysterical body
Authors: Mackiewicz Wojciech , Barański Jarosław
Published: October 2022

Heterotopia is the space of otherness, a counter-space. A very specific type of heterotopia is a human’s body, especially in its illness and sickness. Hysteria, the disease which can imitate many other diseases, is here a crucial example. From its ancient beginnings until today hysteria makes us reflect on the essence of illness and disease, on the definition of the human condition, on the social role of a healthy and ill human body, etc. The archeology of hysteria explains how disorders shape medical standards.
Szlachetny dzikus Jeana-Jacques’a Rousseau, a anarchoprymitywistyczny powrót do natury
Authors: Gołda Michał
Published: October 2022

Idea „szlachetnego dzikusa” przedstawiona przez Jeana Jacquesa Rousseau została wykorzystana w rozważaniach anarchoprymitywistów. Celem artykułu jest porównacie „szlachetnego dzikusa” Rousseau ze współczesnym „szlachetnym dzikusem” anarchoprymitywistów. Człowiek żyjący w stanie natury Rousseau to figura retoryczna, za sprawą której francuski filozof chciał rozważyć opozycję życia w naturze i poza naturą. Wydobyć różnicę między ludźmi funkcjonującymi w społeczeństwach cywilizowanych, a dzikimi jednostkami pozostającymi w pełnej symbiozie z naturą. Według niego porzucając przyrodę na rzecz życia w społeczeństwie, „szlachetny dzikus” stracił wiele pierwotnych i naturalnych przymiotów, zyskując w zamian profity potrzebne do zbiorowej egzystencji. Anarchoprymitywistyczna technofobia wyraża się w przekonaniu, że nauka i technika nie są w stanie dać człowiekowi szczęścia oraz prowadzą do degradacji środowiska, alienacji człowieka z natury I zniewolenia ludzi przez system. Postulowany przez nich powrót do natury ma na celu odrzucenie technologii, cywilizacji i społecznych zwierzchności oraz przejście z osiadłego do łowiecko-zbierackiego trybu życia. Ma to na nowo „obudzić” w ludziach szczęśliwego, szlachetnego dzikusa. Czy jest to jednak możliwe? Czy człowiek żyjący w symbiozie z naturą, postulowany przez anarchoprymitywistów, jest jedynie figurą retoryczną, jak obecny w filozofii Rousseau szlachetny dzikus? Czy możliwy jest prawdziwy powrót do natury, czy są to tylko I wyłącznie ideologiczne spekulacje?