bluuebunny/crossref_metadata_2025 huggingface dataset:
La pragmática de un etiquetaje pragmático para la plataforma observahumor.com
Authors: Ruiz Gurillo Leonor
Published: November 2023

Trabajar con un hecho pragmático como el humor, dependiente del género discursivo en el que aparece y del contrato conversacional que establecen el hablante- escritor y el oyente-lector (Ruiz Gurillo, 2016), es una tarea compleja. En este sentido, recoger corpus lingüísticos basados en las evidencias investigadoras y metodológicas comprobadas a lo largo de los últimos años se convierte en un desafío para el investigador interesado en la pragmática del español. Este artículo presenta la necesidad de contar con un etiquetaje pragmático para poder aplicarlo a un corpus de humor, en concreto a la plataforma OBSERVAHUMOR.COM. Aunque la bibliografía ha insistido en marcas humorísticas que constituyen pistas que ayudan a los destinatarios a interpretar el humor (véase, entre otros, Burgers y van Mulken, 2017), conviene discriminar otro grupo de elementos, los indicadores humorísticos. Se trata de elementos comunes en la lengua que, sin embargo, se convierten en elementos de por sí humorísticos en un contexto dado (Ruiz Gurillo, 2014; Timofeeva y Ruiz Gurillo, 2021). El repaso de las distintas marcas e indicadores humorísticos que actúan en diferentes corpus de humor constituye la base para la propuesta de un etiquetaje pragmático que se ilustra con los distintos corpus que componen la plataforma: CHILDHUM, VALESCO.HUMOR, ERASMUS.HUMOR, COLUMNAS.HUMOR, FEMMES.UP y BLOGS.HUMOR.
Los campos del léxico escatológico en el humor negro infantil
Authors: Jiménez Ruiz Juan Luis
Published: November 2023

El objetivo de nuestra investigación consiste en la comprobación de los procesos lingüísticos inferenciales que están detrás del fenómeno del humor negro o de mal gusto en la población infantil. Para ello, partiendo de los resultados obtenidos en el Proyecto “Metapragmática del humor infantil: adquisición, perspectiva de género y aplicaciones” (GRE 14-19, Universidad de Alicante), vamos a observar las manifestaciones lingüísticas que emplea la población infantil para expresar el humor negro o de mal gusto. Y nos vamos a centrar en este trabajo en el análisis de los campos del léxico escatológico, como expresión de este humor negro o de mal gusto, empleado por los niños y niñas de edad comprendida entre los 8 y los 12 años.
Cytotoxic activity of ethyl acetate extract of Chromolaena odorata on MCF7 and T47D breast cancer cells
Authors: Yusuf Hanifah , Novia Hijra , Fahriani Marhami
Published: November 2023

One of the most cancers in women that can be fatal is breast cancer. Radiation therapy, chemotherapy, or a combination of the two are often used to treat cancer, and these treatments tend to modify the immune system and weaken defences. Using natural compounds from plants has become a research interest to prevent cancer cell development. The aim of this study was to determine the anticancer activities of ethyl acetate extract of Chromolaena odorata (EACO) against breast cancer cells (MCF-7 and T47D). The viability of the cells was determined by the MTT colorimetry assays. The apoptosis test was performed by using flow cytometry. The IC50 value for MCF-7 cells was 218.78 μg/mL and 307.61 μg/mL for T47D. The extract acted selectively against breast cancer cells, with selectivity indexes against MCF-7 and T47D were 12.77 and 9.08, respectively. The viable cells of T47D cells were decreased from 85±36.5% (24 hours) to 54±34% (48 hours) after treatment with IC50 of EACO. Significant decrease of the MCF-7's viable cells were observed between 48 and 72 hours after treatment with IC50 (68.5±17.7% to 51.01±12.1%, respectively). Apoptosis assay showed that T47D and MCF-7 cells were mainly in the necrosis stage (83.35±0.49% and 95.15±1.76%, respectively). This study suggested that ethyl acetate extract of C. odorata is promising to be developed as an anticancer agent.
Criminalization of destroying or wasting bank property: between necessity and excess of incrimination
Authors: Negritu Ludmila
Published: November 2023

In this scientific research, we are interested in the analysis of the criminal norms whose regulatory object is the acts of intentional destruction or waste of the bank’s property by the bank’s administrator, in the administration process, approach carried out through the chain of systematic, critical and comparative interpretation of the relevant provisions. The purpose of the action undertaken is to reveal the need to criminalize the named offenses as a result of the finding of a parallel framework for their criminalization, consequently revealing an excess of criminal regulation due to the “ambiguities” that characterize the incriminating precept, recorded in paragraph (3) art. 197 of the Criminal Code of the Republic of Moldova, located in Chapter VI of the Special Part of the Criminal Code, entitled “Offenses against patrimony”.
Development and In Vitro Evaluation of Nanoparticles of Silymarin Using Central Composite Design
Authors: Agrawal Yashu , Goyal Manoj Kumar
Published: November 2023

Silymarin is a phytoconstituent derived from the plant Silybum marianum with poor oral absorption and bioavailability but possesses hepatoprotective activity, anticancer activity, cardioprotective, neuroprotective, stabilizing, anti-inflammatory, and antioxidant activity. Therefore, the current work aims to develop a nanoformulation of silymarin to increase bioavailability, reduce dosing frequency, minimize toxicity, and improve patient compliance. Silymarin nanoparticles were created via the ionic gelation technique, employing chitosan and TPP as the primary polymers. A central composite design was employed for formulation optimization. Chitosan and TPP were employed as independent variables, while particle size and encapsulation efficiency were considered as dependent variables. The prepared nanoparticles were evaluated through entrapment efficiency, in vitro drug release, and drug-excipient interaction studies. Thirteen experiments were conducted using the experimental runs created by the central composite design. The average particle size was between 149nm and 294nm. The encapsulation efficiency percentage was between 65.4% and 87.3%. The polydispersity index had a value of 0.437. The zeta potential of the optimized formulation was determined to be 38.1 mV. The compatibility studies between the drug and excipients were confirmed using Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimetry. The successful encapsulation of silymarin within the polymer core was verified through scanning electron microscopy analysis. The silymarin-loaded nanoparticles were observed to have a significant drug release of 98,942.43% over 24 hours. The outcomes of the study of Silymarin nanoparticles showed a substantial increase in the dissolution rate, which can be ascribed to the changed solubility properties of the drug. This result is consistent with the stated aim of improving drug absorption.

Keywords: Silymarin, nanoformulation, central composite design.
Application of the React Model Containing Ethnomathematics of Javanese Scripture to Develop the Character of Love of Homeland and Student Learning Outcomes
Authors: Eriawandi Dio , Saptono Sigit , Sugiyo Pranoto Yuli Kurniawati
Published: November 2023

This research was conducted at SDN Sangiang 3 Tangerang and SDN Gandasari 2 Tangerang on class IV students. This research focused on mathematics subjects using the REACT model containing Javanese ethnomathematics to develop the character of love for the country and student learning outcomes because students' knowledge of local wisdom is still low, which can be connected to mathematics lessons. The method used in the research is quasi-experimental with a quantitative approach. The experimental design used in this research is a simple experimental design (Pretest-Posttest Control Group Design). The population in this study were all fourth grade students at SDN Sangiang 3 Tangerang and SDN Gandasari 2 Tangerang. The samples in this study were the experimental class at SDN Sangiang III and the control class at SDN Gandasari II, with a total of 60 students. The data collection techniques and instruments in this research are observation, questionnaire instruments, and test instruments. The data analysis technique in this research uses the N-Gaian test and a related sample t-test (polled variance). Based on the analysis results from the N-gain test with a result of 0.732, it shows that the application of the REACT model assisted by Javanese ethnomathematics can improve student learning outcomes. Likewise, the results of the descriptive analysis show that the average calculation of students' love of their homeland character before and after being given the REACT learning model with the help of ethnomathematics Javanese script experienced an average increase of 2.43 points, and the results of the Pillai's Trace, Wlks'Lambda, Hotelling's Trace, or Roy's Largest Root tests were all the same, namely a value of 0.000, meaning this is less than the set significance of 5%, therefore Ho is rejected. In other words, the application of the REACT learning model assisted by Javanese ethnomathematics can influence the character of love for one's country and the results of learning mathematics curve material simultaneously.

Keywords: React Model, Ethnomathematics, Javanese Script, Love Of Homeland Characters, Learning Outcomes
Plastik Biodegradable Berbasis Carboxymethyl Cellulose dari Ampas Tebu
Authors: Rahmasari Etyka , Zamhari Mustain , Silviyati Idha
Published: November 2023

Penumpukan sampah plastik sintetik pada lingkungan dapat menyebabkan pencemaran lingkungan, guna menanggulangi hal tersebut maka munculah inovasi untuk mengganti penggunaan plastik sintetik dengan plastik biodegradable. Biopolimer yang berpotensi sebagai bahan baku carboxymethyl cellulose adalah ampas tebu yang mengandung selulosa mencapai 40-50%. Selulosa yang digunakan sebagai bahan baku plastik biodegradable harus diturunkan terlebih dahulu. Salah satu turunan selulosa adalah Carboxymethyl Cellulose (CMC). Carboxymethyl Cellulose adalah eter polimer selulosa berbentuk linier, bersifat biodegradable, dan tidak beracun. Sintesis CMC dilakukan dengan reaksi alkalisasi dan karboksimetilasi menggunakan media pelarut. Pembuatan CMC diawali dengan ekstraksi selulosa ampas tebu, kemudian selulosa melalui proses alkalisasi menggunakan NaOH konsentrasi 5%, 15%, 25%, 35%, dan 45% dalam media reaksi berupa isopropanol. Tahap berikutnya adalah proses karboksimetilasi menggunakan asam trikloroasetat (TCA) konsentrasi 15%, 20%, dan 25%. Hasil penelitian menunjukkan bahwa Carboxymethyl Cellulose yang didapatkan telah memenuhi SNI 06-3736-1995 adalah pada konsentrasi NaOH 35% dan konsentrasi asam trikloroasetat 20% dengan hasil analisis derajat substitusi, kemurnian, dan pH berturut-turut yaitu 0,82, 99,80%, dan 7,02. Penambahan Carboxymethyl Cellulose berpengaruh terhadap kemampuan plastik biodegradable dimana dari hasil pengamatan plastik biodegradable yang dihasilkan dapat terdegradasi 100% dalam 4 hari dengan nilai kuat tarik sebesar 6,946 MPa, dan %elongasi sebesar 12%.
Ultrasound examination of mammary glands in patients with infertility on background violations of menstrual function
Authors: Gladenko Svitlana
Published: November 2023

The objective. Іs to investigate the state of the mammary glands in patients with infertility of endocrine genesis.
Materials and methods. The study was conducted in 110 patients with endocrine infertility who underwent an ultrasound examination of the mammary glands. The first group (n=52) consisted of patients with a regular menstrual cycle against the background of luteal phase insufficiency, the second group (n=58) consisted of patients with a menstrual cycle disorder with anovulation. Statistical processing of the research results was carried out using the standard programs "Microsoft Excel 5.0" and "Statistica 8.0".
Results and their discussion. Changes in the mammary glands according to the type of PCH in the studied group were found in 44 out of 110 patients (40.0%), underdevelopment of the structural elements of the mammary glands - in 19 out of 110 (17.3%), early involutional changes - in 6 out of 110 (65, 4%), focal formations – in 4 out of 110 (3.6%). The frequency of fibrocystic disease in patients of the II group was 1.3 times higher compared to the I group - 24 (41.3%) versus 20 (38.4%), respectively, p<0.01. At the same time, focal mammary gland formations of the fibroadenoma type were diagnosed 3.5 times more often in patients of the I group - 3 (5.8%) versus 1 (1.7%) in the II group, p<0,01.
Conclusions. In infertility of endocrine genesis, the first place in the structure of mammary gland pathology is diffuse fibrocystic disease - 40.0%. The frequency of underdevelopment of mammary glands is 17.3%, early involutional changes 10.3%, and focal formations like fibroadenoma are 3.6% of cases.
Molecular Docking of Andrographoilde and HDAC2 inhibitor an approach to manage for Beta Thalassemia
Authors: Khare Soumya , Chatterjee Tanushree , Gupta Shailendra , Patel Ashish
Published: November 2023

Beta thalassemia is a disorder of globin gene synthesis resulting in the absent production of beta globin chain in RBC. The property of inducing gamma globin gene expression by the search for bioactive compounds exhibiting is of great interest. Regulation of HDAC activity by dietary flavones couldhave important implication in developing epigenetic therapy to regulate the cell geneexpression. Several pharmacological agents have been identified overthe past two decades that reactivate gamma globin gene transcription through differentcellular system. We will search for the complementary and alternative medicine (CAM)which regulated switch from fetal to adult globin gene expression could be prevented hasresult in the development of new class of therapeutic agent consisting of some bioactivecompounds such as flavanone for the treatment of beta thalassemia. Flavones one suchmolecule of plant origin are known to interfere with HDAC2 enzyme and to enhance theacetylation restoring cell homeostasis, p38 MAPK pathway. Induction of HbF expression inerythroid cells is an important and another therapeutic approach in beta thalassemia. We used Schrodinger suites to develop computational approaches for estimating drug and target binding affinities. The target enzyme's sequence alignments contain 539 amino acid residues, and bioactive compounds that act as ligand molecules were acquired from the plant Andrographis paniculata. We used molecular docking, and ADME analysis. The current study explores the binding pattern of Andrographoilde and Vorinostat (SAHA) against their target protein (PDBIDs: 6G3O), respectively using molecular docking approaches. The molecular docking results show that Andrographoilde binds within the active region of HDAC2 inhibitors by forming hydrogen bonds against ASP104 and TYR 308 respectively. However, the Vorinostat interacts with TYR 308 and GLY 142respectively. Our comparative results show that andrographoilde may be a similar therapeutic agent for managing beta thalassemia as compare to vorinostat. However, functional studies are needed to confirm their proposed relevance in beta thalassemia in vitro and in vivo evaluation studies are required.
Conformity assessment of Pharmaceutical Storage on the Rural Public Health Center of West Kalimantan Indonesia
Authors: Ghozali MT , Mahar Astuti Yeni
Published: November 2023

The storage condition of pharmaceutical drugs and medical disposables in the primary healthcare providers (e.g., public health centers) should meet the required quality standard to maximize financial profit and avoid loss. In order to ensure this matter, a conformity assessment is required. This study aimed to examine the conformity of the storage condition in the rural public health center of Dalam Kaum village, West Kalimantan, Indonesia, with the Regulation of the Minister of Health of the Republic of Indonesia Number 74 of 2016 and the indicators for the storage of pharmaceutical drugs and medical disposables. This study was a descriptive non-experimental method applying quantitative and qualitative approaches by observation using a checklist and interviews. Overviews of the conditions were compared with guidelines sourced from the Regulation, including storage method, storage stability, flammable and explosive material storage, narcotic and psychotropic drug storage, and storage with risk of contamination. In addition, the indicators included the percentage of damaged or expired drugs, dead stock of drugs, and turnover ratio (TOR). The study's findings reported that the conformity of the storage condition based on the Regulation was 100% for storage method, storagestability,narcotic and psychotropic drug storage, and storage with risk of contamination, while 0% was for flammable and explosive material storage. In terms of the indicators, this study found 10.8% for damaged or expired drugs, 53.4% for dead stock of drugs, and 8.53 times per year for TOR. Based on the findings, it could be concluded that almost all aspects of the public health center of Dalam Kaum village conformed to the Regulation of the Minister of Health of the Republic of Indonesia. Unfortunately, only one aspect showed conformity regarding the indicators for the storage of pharmaceutical drugs and medical disposables.
Effects of the Aronia Melanocarpa extract action on the activity of mitochondrial creatine kinase under immobilization stress in old rats
Authors: SHVETS Volodymyr , MASLAK Hanna , DAVYDOV Vadim , BEREST Halyna , NOSULENKO Inna , VOSKOBOİNİK Oleksii , OMELİANCHYK Liudmyla , BRAZHKO Oleksandr
Published: November 2023

The effects of the Aronia melanocarpa extract on mitochondrial creatine kinase isoenzyme of the old rats heart under stress were studied. The research was performed on 30 male rats of the Wistar line. For expiriment were used old (22–25 months) animals. It was established, that the injection of the extract (Aronia melanocarpa) at a dose of 0.2 g/kg 60 minutes before the immobilization has limited sensitivity of the heart muscle’s CPK-MT to damaging stress factors (reduced medium pH, increased medium tonicity, increased concentration of calcium, activated free radical processes), and helps the normalization of its kinetic properties, has an influence on the myocardium’s kinetic supply. Thus, the extract of Aronia melanocarpa increases the myocardial resistance to the injury effect of stress.
Impact of timing of antiseizure medication withdrawal on seizure recurrence in glioma patients: a retrospective observational study
Authors: Meer Pim van der
Published: November 2023

Join the Journal of Neuro-Oncology's Editor-In-Cheif, Dr. Jason Sheehan, and Associate Editor, Dr. Randy D'Amico, for a discussion with Dr. Pim van der Meer on his latest publication on the impact of timing of antiseizure medication withdrawal on seizure recurrence in glioma patients.
Pengaruh Financial Distress, Growth Opportunities Dan Managerial Ownership Terhadap Accounting Conservatism Dengan Risk Litigation Sebagai Moderasi Pada Perusahaan Manufaktur Di Bursa Efek Indonesia 2019-2021
Authors: Dhanendra Dhanendra , Trisnawati Estralita , Verawati Verawati
Published: November 2023

Konservatisme akuntansi merupakan prinsip untuk mengakui beban sebanyak-sebanyak dibandingkan dengan pendapatan sehingga dapat menghasilkan laba yang konservatif. Hal tersebut bertujuan untuk mengurangi sikap oportunis yang ditunjukkan oleh manajer dalam menyajikan laporan keuangan. Laporan keuangan merupakan gambaran kinerja pada suatu perusahaan, sehingga para manajer selalu mengusahakan untuk menghasilkan kinerja laporan keuangan yang baik supaya para pemangku kepentingan menilai bahwa kinerja manajemen tersebut baik. Hal tersebut tentunya akan mempengaruhi sikap konservatif dalam penyajian laporan keuangan perusahaan. Penelitian ini bertujuan untuk menguji apakah financial distress, growth opportunites, dan managerial ownership mempengaruhi accounting conservatism pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2019-2021 dengan risk litigation sebagai variabel moderasi. Firm size merupakan variabel kontrol yang ditambahkan pada penelitian ini. Penelitian ini menggunakan perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia pada tiga periode yaitu dari tahun 2019 ke tahun 2021 yang memiliki populasi sebanyak 513 sampel perusahaan. Teknik pemilihan sampel pada penelitian ini menggunakan teknik pemilihan sampel purposive sampling yaitu teknik pemilihan sampel dengan kriteria-kriteria yang telah ditentukan sehingga hasil dari teknik pemilihan sampel tersebut, sampel yang terpilih adalah sebanyak 99 perusahaan. Sumber data yang digunakan pada penelitian ini merupakan data sekunder yang berupa laporan keuangan perusahaan manufaktur yang diperoleh dari situs resmi Bursa Efek Indonesia. Metode analisis penelitian ini adalah regresi data panel, dengan menggunakan software Eviews 13. Hasil dari penelitian ini adalah financial distress berpengaruh negatif terhadap accounting conservatism sedangkan growth opportunities dan managerial ownership tidak berpengaruh terhadap accounting conservatism. Risk litigation sebagai variabel moderasi tidak dapat memoderasi hubungan antara financial distress, growth opportunities, dan managerial ownership dengan accounting conservatism.
Penilaian Pembelajaran Bahasa Indonesia Dalam Kurikulum Merdeka Berbasis Digital (I-EVAL)
Authors: Supriyono Supriyono , Subyantoro Subyantoro , Pristiwati Rahayu
Published: November 2023

Peningkatan mutu pendidikan di Indonesia telah dilakukan sejak tahun 2009 oleh pemerintah Indonesia. Pemerintah telah memenuhi kewajiban anggaran pendidikan sebesar 20% dari APBN dan terus meningkatkan anggaran pendidikan dari Rp 332,4T pada tahun 2013 menjadi Rp 550T pada tahun 2021. Dari berbagai indikator keberhasilan belajar siswa, belum menunjukkan hasil yang menggembirakan. Krisis pembelajaran diperparah dengan adanya pandemi covid 19. Covid 19 menyebabkan learning loss. Untuk mengantisipasi learning loss dan learning gap di Kementerian Pendidikan dan Kebudayaan (sekarang Kemendikbudristek), telah memberlakukan Kurikulum Darurat. Kurikulum Darurat secara signifikan mampu mengurangi indikasi learning loss dan learning gap selama pandemi baik untuk pencapaian literasi maupun numerasi. Untuk mengatasi potensi learning loss dan learning gap selama pandemi, perlu dikembangkan kurikulum yang secara komprehensif mampu mengatasi krisis pembelajaran yang merupakan masalah akut di Indonesia. Melihat berbagai tantangan yang terjadi, Kementerian Pendidikan, Kebudayaan, Riset dan Teknologi (Kemendikbudristek) berupaya melakukan upaya pemulihan pembelajaran. Salah satu upaya yang dilakukan Kemendikbudristek untuk mengatasi permasalahan yang ada adalah dengan menerapkan Kurikulum Merdeka (yang sebelumnya disebut Kurikulum Prototipe). Pelaksanaan Kurikulum Merdeka menuntut guru untuk memahami esensi Kurikulum Merdeka termasuk pelaksanaan penilaian (assesmen). Penilaian yang dilakukan berfungsi sebagai proses pembelajaran (assessment as learning), untuk proses pembelajaran (assessment for learning), dan penilaian pada akhir proses pembelajaran (assessment of learning) yang berbasis pada digital atau internat evaluation (I-Eval)
Exchange Trade Fund (ETF) Syariah Sebagai Alternatif Investasi Halal
Authors: Suryosumirat R. Adji
Published: November 2023

Perkembangan pasar modal di Indonesia berkembang sangat pesat, pada pasar modal terdapat berbagai bentuk produk investasi yang ditawarkan. Salah satu produk investasi yang ditawarkan adalah Exchange Trade Fund (ETF). Penelitian ini bertujuan untuk melihat tantangan dan peluang dari ETF Syariah sebagai alternatif investasi halal. Penelitian ini menggunakan metode kualitatif. Sedangkan analisis data terdiri dari reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian didapatkan bahwa investasi dalam ETF Syariah juga memberikan akses kepada investor ke pasar modal global dengan menawarkan eksposur pada saham-saham atau instrumen keuangan syariah di berbagai negara. Sebagai alternatif investasi halal, ETF Syariah harus tetap mematuhi prinsip-prinsip syariah, termasuk larangan terhadap riba, maisir, dan gharar. Oleh karena itu, investor perlu memastikan bahwa ETF yang dipilih telah terverifikasi oleh otoritas yang berwenang dan memenuhi standar syariah yang ditetapkan.
Pengaruh Pelatihan Dan Motivasi Kerja Terhadap Kinerja Karyawan Pada PT Bank Panin Cabang Palembang
Authors: Chandrasari Yohana Theresia Evrata , Perizade Badia , Zunaidah Zunaidah , Widiyanti Marlina
Published: November 2023

Penelitian ini dilakukan bertujuan untuk mengetahui pengaruh pelatihan dan motivasi kerja terhadap kinerja karyawan pada PT Bank Panin Cabang Palembang. Populasi dalam penelitian ini adalah seluruh karyawan tetap PT Bank Panin cabang Palembang pada tahun 2023 sebanyak 117 karyawan. Penentuan jumlah sampel yang digunakan oleh penulis dalam penelitian ini adalah dengan metode sensus (sampling jenuh) yang merupakan teknik penentuan sampel bila semua anggota populasi digunakan sebagai sampel. Hasil dari analisis linier berganda menunjukkan bahwa pelatihan dan motivasi kerja berpengaruh positif dan signifikan terhadap kinerja karyawan. Pelatihan, perlu adanya riset dalam memilih mengenai vendor, instruktur pelatihan serta materi pelatihan. Pada kategori instruktur, karyawan merasakan ada beberapa instruktur pada pelatihan belum terlalu menguasai materi pelatihan yang disampaikan. Motivasi kerja, diharapkan perlu adanya rolling dengan beberapa bagian unit kerja agar hubungan baik tetap terjalin antara pegawai. Selain itu juga perlu adanya penambahan kegiatan diluar jam kantor seperti makan bersama, family gathering yang bertujuan untuk memberikan hubungan yang lebih harmonis kepada sesama pegawai maupun atasan.
Analysis of clinicopathological features and prognostic factors of breast cancer brain metastasis
Authors: Chen Yu-Rui , Xu Zu-Xin , Jiang Li-Xin , Dong Zhi-Wei , Yu Peng-Fei , Zhang Zhi , Gu Guo-Li
Published: November 2023

BACKGROUND

Breast cancer (BC) has become the most common malignancy in women. The incidence and detection rates of BC brain metastasis (BCBM) have increased with the progress of imaging, multidisciplinary treatment techniques and the extension of survival time of BC patients. BM seriously affects the quality of life and sur-vival prognosis of BC patients. Therefore, clinical research on the clinicopathological features and prognostic factors of BCBM is valuable. By analyzing the clinicopathological parameters of BCBM patients, and assessing the risk factors and prognostic indicators, we can perform hierarchical diagnosis and treatment on the high-risk population of BCBM, and achieve clinical benefits of early diagnosis and treatment.

AIM

To explore the clinicopathological features and prognostic factors of BCBM, and provide references for diagnosis, treatment and management of BCBM.

METHODS

The clinicopathological data of 68 BCBM patients admitted to the Air Force Medical Center, Chinese People’s Liberation Army (formerly Air Force General Hospital) from 2000 to 2022 were collected. Another 136 BC patients without BM were matched at a ratio of 1:2 based on the age and site of onset for retrospective analysis. Categorical data were subjected to χ 2 test or Fisher’s exact probability test, and the variables with P < 0.05 in the univariate Cox proportional hazards model were incorporated into the multivariate model to identify high-risk factors and independent prognostic factors of BCBM, with a hazard ratio (HR) > 1 suggesting poor prognostic factors. The survival time of patients was estimated by the Kaplan–Meier method, and overall survival was compared between groups by log-rank test.

RESULTS

Multivariate Cox regression analysis showed that patients with stage III/IV tumor at initial diagnosis [HR: 5.58, 95% confidence interval (CI): 1.99–15.68], lung metastasis (HR: 24.18, 95%CI: 6.40–91.43), human epidermal growth factor receptor 2 (HER2)-overexpressing BC and triple-negative BC were more prone to BM. As can be seen from the prognostic data, 52 of the 68 BCBM patients had died by the end of follow-up, and the median time from diagnosis of BC to the occurrence of BM and from the occurrence of BM to death or last follow-up was 33.5 and 14 mo, respectively. It was confirmed by multivariate Cox regression analysis that patients with neurological symptoms (HR: 1.923, 95%CI: 1.005–3.680), with bone metastasis (HR: 2.011, 95%CI: 1.056-3.831), and BM of HER2-overexpressing and triple-negative BC had shorter survival time.

CONCLUSION

HER2-overexpressing, triple-negative BC, late tumor stage and lung metastasis are risk factors of BM. The presence of neurological symptoms, bone metastasis, and molecular type are influencing prognosis factors of BCBM.
Clinical study of standard residual liver volume and transient elastography in predicting poor prognosis of patients after hemihepatectomy
Authors: Yue Zhi-Qiang , Zhang Peng , Yan Shuai , Ju Lin-Ling , Wang Hui-Xuan , Yuan Liu-Xia , Chen Lin , Wu Jin-Zhu , Cao Ya-Li
Published: November 2023

BACKGROUND

Liver cancer resection, especially in patients with hemihepatectomy or extended hemihepatectomy, often leads to poor prognosis, such as liver insufficiency and even liver failure and death, because the standard residual liver volume (SRLV) cannot be fully compensated after surgery.

AIM

To explore the risk factors of poor prognosis after hemihepatectomy for hepatocellular carcinoma and evaluate the application value of related prognostic approaches.

METHODS

The clinical data of 35 patients with primary liver cancer in Nantong Third People's Hospital from February 2016 to July 2020 were retrospectively analyzed. The receiver operating characteristic curve was created using medcac19.0.4 to compare the critical values of the SRLV in different stages of liver fibrosis after hemihepatectomy with those of liver dysfunction after hemihepatectomy. It was constructed by combining the Child-Pugh score to evaluate its application value in predicting liver function compensation.

RESULTS

The liver stiffness measure (LSM) value and SRLV were associated with liver dysfunction after hemihepatectomy. Logistic regression analysis showed that an LSM value ≥ 25 kPa [odds ratio (OR) = 6.254, P < 0.05] and SRLV ≤ 0.290 L/m2 (OR = 5.686, P < 0.05) were independent risk factors for postoperative liver dysfunction. The accuracy of the new liver reserve evaluation model for predicting postoperative liver function was higher than that of the Child-Pugh score (P < 0.05).

CONCLUSION

SRLV and LSM values can be used to evaluate the safety of hemihepatectomy. The new liver reserve evaluation model has good application potential in the evaluation of liver reserve function after hemihepatectomy.
An efficient sensor based on anodic activation of graphene oxide for sensitive and selective determination of dopamine in blood serum
Authors: Khudaish EMAD ALDEEN , Al Ghafri Lamiya , Al Hatmi Nusiba , Joudi Salah
Published: November 2023

A native graphene oxide (NGO) prepared by Hummers modified method was used as the template materials for the fabrication of electrochemically oxidative graphene oxide (OGO) onto a glassy carbon electrode (GCE). The fabrication of OGO-GCE persuaded via anodic reversible potentiodynamic of NGO base surface materials that increases the concentration of oxygen functionalities. The development of a new aldehyde/alcoholic functional group on OGO-GCE characterized by XPS analysis is a marked signal for oxygen richness surface which provoked on the cost of sp2 hybridized function. The EIS data underline that OGO-GCE promote the electron transfer kinetics much more than NGO-GCE by 9 times as estimated by the rate constant calculation. The XPS and EIS data highlight the influence of anodic treatment on increasing the interlayer spacing distance between the resultant OGO. Differential pulse voltammetry (DPV) results were evident for a promising efficiency of OGO-GCE on the simultaneous determination of dopamine (DA), ascorbic acid (AA) and uric acid (UA). In addition, the selectivity of the proposed sensor for DA quantification in the presence of high concentrations of AA and UA was achieved successfully with a detection limit (DL3s) approach to 12 nM. The analytical performance of OGO-GCE on serum blood revealed its potential application for trace DA quantification.
Teknologi Arsip Digital sebagai Upaya Peningkatan Layanan Administrasi di Kelurahan Sungai Pinang Luar Kota Samarinda
Authors: Puspitasari Novianti , Septiarini Anindita , Hakim Muhammad Irvan , Afifah Dinda Nur , Salsabila Zahra , Fornia Daviana Dwitasari Enka , Wahyudi Moh Ikhwan , Pramudya Pranata Eka , Hanif Ahmad Luthfi
Published: November 2023

Pelayanan prima merupakan hal yang sangat penting dilakukan bagi organisasi maupun instansi. Di dalam sebuah instansi khususnya instansi yang menyediakan pelayanan administrasi untuk masyarakat sangat penting untuk melakukan transformasi digital dalam hal pengelolaan kearsipan (dokumen). Namun, saat ini instansi yang melayani administrasi berkaitan dengan dokumen masyarakat khususnya surat menyurat masih belum maksimal dalam pelayanan dan pengelolaan arsipnya. Masalah inilah yang ditemui di Kelurahan Sungai Pinang Luar. Proses pelayanan administrasi terkait pembuatan surat menyurat masih dilakukan secara konvesional. Masyarakat harus mendatangi pihak kelurahan untuk membuat surat, kemudian perangkat desa membuat surat tersebut dengan waktu tunggu yang cukup lama. Selain itu dokumen yang telah selesai dibuat tidak berbentuk digital sehingga perangkat desa terkadang kesulitan untuk menemukan kembali dokumen yang dibutuhkan dengan cepat. Oleh karena itu, diperlukan manajemen kearsipan melalui transformasi digital pada proses pelayanan administrasi. Kegiatan pengabdian masyarakat ini mengusulkan proses digitalisasi dokumen berupa metode pendampingan peningkatan keterampilan Sumber Daya Manusia (SDM) berbasis teknologi yang merupakan program kemitraan masyarakat antara perguruan tinggi dengan perangkat desa dan masyarakat. Program ini mentransfer pengetahuan tentang digitalisasi dokumen dan teknologi QR-Code berupa sosialisasi dan pelatihan tentang penggunaan QR-Code, LinkTree dan Google Form untuk mengelola arsip, menyebarkan dokumen dan mempermudah masyarakat untuk mengurus dokumen kependudukannya. Hasil dari kegiatan ini mampu memberikan pemahaman kepada perangkat desa dan masyarakat serta diterapkan secara berkelanjutan oleh masyarakat serta perangkat desa.
Biodiesel production: An updated review of evidence
Authors: Ravindra B. Malabadi  , Sadiya MR  , Kiran P. Kolkar  , Raju K. Chalannavar
Published: November 2023

This review paper highlights the production of biodiesel from different plant based feedstocks via the transesterification process. Biodiesel is a renewable, non-toxic, environment-friendly and an economically feasible option to tackle the depleting fossil fuels and its negative environmental impact. Biodiesel in general possess higher kinematic viscosity and density than conventional diesel. However, because of food security concerns, the use of edible oil in biodiesel production is criticized globally. Non-edible plant oils, waste cooking oils, and edible oil industry byproducts are suggested as effective biodiesel feedstocks because nonedible feedstock does not compete with food from human consumption. High-potential second-generation feedstock for biodiesel production uses waist cooking oil, acid oil, and animal tallow. Non edible crops in India as a feedstock for biodiesel production are yellow oleander oil (Cascabela thevetia), Pongamia (Pongamia pinnata), Jatropha curcas, Mahua (Madhuca longifolia), Candlenut (Aleurites moluccanus), Rubber (Hevea brasiliensis), Soapnut (Sapindus mukorossi), Jojoba (Simmondsia chinensis), Tobacco (Nicotiana tabacum), Neem (Azadirachta indica), Karanja (Millettia pinnata), Castor (Ricinus communis), Polanga (Calophyllum inophyllum L), Cotton (Gossypium), Kusum (Carthamus tinctorius), Yellow oleander (Cascabela thevetia), Sea mango (Cerbera odollam), Tung (Vernicia fordii), and Bottle tree (Brachychiton rupestris). Biodiesel is a sustainable liquid bio-energy resource that might be used to replace diesel fuel. Despite having numerous advantages over conventional diesel, the biodiesel industry is still struggling in India because of various reasons and challenges like availability, high feedstock pricing, operational hurdles, and supply-chain management challenges.
Improvement of modern machine technologies for the care of cereal crops
Authors: Dimitri natroshvili  , Malxaz Dolidze  , Maia Lomishvili  , Mate Abuladze
Published: November 2023

The development of agricultural reclamation is primarily focused on solving the problem of food security by ensuring the sustainable and innovative development of agriculture and the effective assimilation of agricultural soils and natural resources using complex reclamation measures that depend on the introduction of new, resource-saving technologies and technical means of reclamation works. The most energy-intensive process in the entire technological cycle of caring for grain crops is soil processing, on which 50-60% of fuel is spent on average. The most energy-intensive process in the entire technological cycle of caring for grain crops is soil processing, on which 50-60% of fuel is spent on average Raising the care of cereal crops by 30-60% is achieved as a result of the intensification of mechanized work. The use of modern technical means in the restoration and construction of the country's reclamation systems is incredible without knowing their operating indicators, the main characteristics and parameters of the car; Water resources on the territory of Georgia are unevenly distributed: 1.34 million m3/km2 per year for western Georgia and 0.37 million m3/km2 for Eastern Georgia. Therefore, it is necessary to arrange irrigation systems in the eastern and southern regions of the country, and in the west - drainage systems. Therefore, the paper proposes two-rotor channel machines imported into Georgia, which allow the withdrawal of open channels to a depth of up to 1.45 m, which is used mainly for drainage and irrigation. The parameters of the working body of the rotary channel plugs, the determination of engine power and the hatching of the base car are calculated.
Behavior of Infringement of Online Virtual Property --In the Prospective of Criminal Law
Authors: Liu Jinrou
Published: November 2023

Entering the Internet information era, although attached to specific network technology, virtual property has established a close relationship with real property. By selling the wealth created in virtual space, people can convert their virtual property into real wealth, which has led to a high incidence of illegal acquisition of virtual property in recent years. However, the academic community and judicial practice have been debated for many years regarding the infringement of virtual property in cyberspace, and so far, a consensus has yet to be reached. In the academic community, a unified viewpoint on the legal attribute of the virtual property has yet to be formed; whether the virtual property is data or property has yet to be determined. In judicial practice, differences in the selection of the crime and punishment have also been a long-standing issue. Therefore, conducting an in-depth study on the regulation dilemma of infringing on network virtual property is of great importance.
Research on the Current Situation of Chinese College Students Test Anxiety
Authors: Jiang Panyun
Published: November 2023

Comparing the study pressure of todays students with those of the past, it is obvious that there are heavier bags, more homework, and less sleep time. Students learning pressure is getting heavier and heavier, and there is more and more anxiety about learning. In a specific time period every year, this pressure and anxiety will reach an explosive point, and this time period is often a period of time for students to take exams. This paper focuses on the overall degree of Test Anxiety among Chinese college students and conducts a Chinese-style questionnaire survey of the Test Anxiety Scale. Most Chinese students have a high or very highest anxiety index. This paper analyzes the current situation at the different examination stages for students, namely, before, during, and after the examination. It also provides different relief plans for different students with different test anxiety indexes, such as how to better prepare for exams or adjust their mentality.
Fostering Holistic Development: Exploring the Integration of Positive Psychology, Constructivist Teaching, and STEAM Education in Hong Kong Secondary Schools
Authors: YUEN HONG CHING
Published: November 2023

The proposed teaching approach strongly emphasizes students, promotes problem-solving skills, and encourages a positive outlook. The framework incorporates essential techniques such as scaffolding, securing, and flexible cognition, which Magoon has shown to support student learning and development. By adopting this constructive teaching approach, this study aims to cultivate critical thinking skills, resilience, and a sense of empowerment among students. This aligns with the principles of positive psychology and emphasizes the holistic development of students well-being. This research also explores integrating positive education with STEAM (Science, Technology, Engineering, Arts, and Mathematics) education. Combining two powerful educational approaches anticipates enhanced learning outcomes and increased student engagement. Students can foster creativity, innovation, and collaboration by applying their knowledge and skills in real-world contexts. The study highlights the Creating a Better World course offered in Hong Kong secondary schools as an exemplary model. Through this course, students gradually develop STEAM projects while incorporating positive education principles and cultivating a growth mindset. The results demonstrate that integrating positive education and constructivist instruction can upgrade students autonomous learning and critical thinking skills by providing a motivating and imaginative learning environment. As this integration is applied, teachers are encouraged to explore and innovate continuously to adjust to the necessities of various disciplines and students.
Azerbaycan Türkçesinde ve Türkiye Türkçesinin Doğu Ağızlarında Bulunan tulla- Fiili ve Türevlerinin Kökeni Üzerine.
Authors: NAHMEDOV Ahmet
Published: November 2023

Azerbaycan Türkçesinde ve Türkiye Türkçesinin doğu ağızlarında varlığını sürdüren “tulla-” (atmak, fırlatmak) fiili ve türevleri başka hiçbir çağdaş Türk lehçesinde bulunmamaktadır. Kelimenin “tul” isim köküne {+la-} isimden fiil yapım eki getirilmesiyle oluştuğu açıktır. Çağdaş Türk lehçelerinden sadece Çuvaşçada “dış, dıştaki” anlamında “tul” kelimesi bulunmaktadır. Bu durumda, /r~l/ Türkçesinin temsilcisi olan Hazar/Bulgar Türklerinin Azerbaycan-Anadolu coğrafyasında bulundukları dönemde bu kelimenin dile girdiği ilk ihtimal olarak görülebilir. Gerek Azerbaycan Türkçesinde gerekse de Türkiye Türkçesi ağızlarında bulunan rotasizm ve lambdasizm örnekleri bu olasılığı destekler niteliktedir.

Altay Dilleri Ailesine mensup dillerde tespit ettiğimiz veriler bir ihtimali daha mümkün kılmaktadır: Tungus-Mançu lehçelerinde “dış taraf, dış yüz” anlamında kullanılan ve yazarlar tarafından Proto-Tungusça kökü “*t’uli” olarak kurgulanan bir kelime bulunmaktadır. Bu kelimenin karşılığının /l>ş/ değişimiyle tarihî ve çağdaş Türk lehçelerinde “taraf/yön; karşı taraf” anlamlarına sahip “tuş” (Proto-Türkçede “*dul”) olabileceği ve Hazar/Bulgar Türklerinden çok önce Azerbaycan ve Doğu Anadolu’ya yerleşen boy/boylar tarafından getirildiği ihtimalini de akla getirmektedir.
Horofunction compactifications of symmetric cones under Finsler distances
Authors: Lemmens Bas
Published: November 2023

In this paper we consider symmetric cones equipped with invariant Finsler distances, namely the Thompson distance and the Hilbert distance. We give a complete characterisation of the horofunctions of the symmetric cone \(A_+^\circ\) under the Thompson distance and establish a correspondence between the horofunction compactification of \(A_+^\circ\) and the horofunction compactification of the normed space in the tangent bundle. More precisely, we show that the exponential map extends as a homeomorphism between the horofunction compactification of the normed space in the tangent bundle, which is a JB-algebra, and the horofunction compactification of \(A_+^\circ\). Analogues results are established for the Hilbert distance on the projective symmetric cone \(PA_+^\circ\). The analysis yields a concrete description of the horofunction compactifications of these spaces in terms of the facial structure of the closed unit ball of the dual norm of the norm in the tangent space.
Development and validation of questionnaire regarding KAP survey on pulmonary and systemic TB
Authors: Elbahloul Muftah , Amer Khadija , Alghennai Sana
Published: November 2023

Background and aim:  A high level of awareness on tuberculosis (TB) is crucial for the success of the prevention and treatment among the high risk populations. Having a good knowledge, positive attitude and excellent level of practice towards tuberculosis may increase the acceptance of the control measures and decreasing the risk of contracting the disease.

 Aim of this study. was to develop and validate a questionnaire about knowledge, attitude and practice (KAP) among the nurses working in TB centres in Libya. Methodology: A Cross-sectional study was conducted among 384 randomly selected nurses working in tuberculosis centers in Libya. This study used a self-administrated questionnaire that takes approximately 15 minutes to complete and was generally well received by the respondent’s. The validation involved content validity and internal consistency for reliability.

Results: A total of 384 nurses in tuberculosis centers comprising of 84 (21.9%) were male nurses and 300 (78.1%) were female nurse. The ICC was in the range of 0.63–0.961, P<0.001, while for the attitude component items it was in the range of 0.682–8.99, p<0.001 and for the practice component items it ranged from 0.659–0.981, p<0.001.Cronbach’s alpha coefficient, used to assess internal consistency for knowledge, attitude and practice was.0.702, 0.776 and 0.752; respectively.

Conclusions: The questionnaire on TB knowledge, attitude, and practice was valid and reliable with good items that enable its use for assessing TB –KAP survey among the TB nurses.
Hiệu quả của việc sử dụng mô hình trường trọng lực trái đất toàn cầu trong nội suy trường trọng lực cục bộ bằng phương pháp Collocation
Authors: Nguyễn Văn Sáng
Published: November 2023

Mục đích của nghiên cứu này là đánh giá hiệu quả của việc sử dụng mô hình trường trọng lực trái đất toàn cầu (EGM) trong bài toán nội suy trường trọng lực cục bộ ở Việt Nam bằng phương pháp Collocation. Nội suy dị thường trọng lực bằng phương pháp Collocation và phương pháp sử dụng mô hình EGM theo kỹ thuật “Loại bỏ - Tính toán - Phục hồi” đã được nghiên cứu. Kết quả nội suy được đánh giá bằng cách so sánh với giá trị đã biết. Kết quả thực nghiệm tại Miền Trung - Việt Nam cho thấy: Khi sử dụng mô hình EGM theo kỹ thuật “Loại bỏ - Tính toán - Phục hồi”, độ chính xác nội suy dị thường trọng lực trên khu vực nghiên cứu đã tăng lên 2,5 lần; Các độ lệch dị thường trọng lực đã giảm đi đáng kể so với khi không sử dụng mô hình EGM. Điều này chứng tỏ hiệu quả của việc sử dụng mô hình EGM trong bài toán nội suy trường trọng lực cục bộ.
Mô hình tự động phân loại dữ liệu lớp phủ bề mặt phục vụ kiểm kê khí nhà kính bằng ảnh viễn thám.
Authors: Nông Thị Oanh , Trần Xuân Trường , Tạ Hoàng Trung , Trịnh Việt Nga
Published: November 2023

Gần đây, việc giám sát phát thải khí nhà kính đang nhận được sự quan tâm của các nhà khoa học, các nhà hoạch định chính sách và các cơ quan. Nhằm tính toán mức độ phát thải khí nhà kính, một bản đồ phủ bề mặt chính xác khu vực cần đánh giá là rất cần thiết. Nghiên cứu này sử dụng thuật toán Random Forest, ảnh vệ tinh Landsat 8, Sentinel 1,2, dữ liệu mô hình số địa hình xây dựng mô hình phân loại ảnh viễn thám thành lập bản đồ phủ bề mặt theo khuyến cáo của AFOLU phục vụ kiểm kê khí nhà kính. Kết quả thử nghiệm phân loại ảnh viễn thám trên khu vực Tây Bắc và Tây Nam Bộ cho kết quả độ chính xác tổng thể đạt lần lượt 83% và 80.5%, phù hợp cho xây dựng bản đồ phủ bề mặt phục vụ kiểm kê khí nhà kính.