bluuebunny/crossref_metadata_2025 huggingface dataset:
ABO blood groups and expression of blood group antigens of epithelial ovarian cancer in Chinese women
Authors: Li Lian , Wang Chao , Zhou Jingjing , Wang Lili , Xing Tongyu , Dai Hongji , Zhou Yao , Qi Lisha , Zhao Yanrui , Huang Caiyun , Li Haixin , Liu Ben , Zheng Hong , Chen Kexin , Li Ding
Published: April 2022

Background：The association of ABO blood groups with epithelial ovarian cancer (EOC) risk has been reported. However, the results are inconsistent and little is known about the alterations of histo-blood group antigens expression and ABO gene expression in ovarian tumor tissues. Methods：We used two single nucleotide polymorphisms in ABO gene (rs8176719 and rs8176746) to determine ABO blood group of 1,870 EOC cases and 4,829 controls. Expression of A and B antigen in 70 ovarian tumor tissues and adjacent normal tissues were detected by immunohistochemistry. Gene expression and DNA methylation profiling was detected in ovarian tumor tissues.Results：In this case-control study, blood group A was associated with increased risk for EOC compared with blood group O (OR = 1.18, 95 % CI = 1.03 – 1.36, P = 0.019), this association remained significant after multivariate adjustment (adjusted OR = 1.48, 95% CI= 1.11 – 1.96, P = 0.007). Patients with blood group A had higher rate of aberrant histo-blood group antigen expression compared to patients with blood group O and B (76.5% vs. 21.1%, 5.0%, P<0.001). ABO gene expression was down-regulated in ovarian tumor tissues compared with paired adjacent normal tissues (P = 0.027). NFYB was positively correlated with ABO gene expression (r = 0.38, P<0.001) and DNA methylation level of four CpG sites was significantly inversely correlated with ABO gene expression (cg11879188, r = - 0.3, P = 0.002; cg22535403, r = - 0.30, P = 0.002; cg13506600, r = - 0.22, P = 0.025; cg07241568, r = - 0.21, P = 0.049). Conclusions：We identified blood group A was associated with increased EOC risk in Chinese women and provided the clues of the possible molecular mechanisms of blood group A related to ovarian cancer risk. Functional studies are warrant to clarify the role of A antigen and ABO gene in ovarian cancer carcinogenesis.
Comparative Study between Topical Steroid alone versus Combined Fractional Erbium:YAG laser with Topical Steroid in Treatment of Alopecia Areata
Authors: Shokeir Hesham Ali , Yousry Anas , Ibrahim Shady Mahmoud Attia
Published: April 2022

Introduction: AA is a common autoimmune skin disease that causes hair loss on the scalp and sometimes other areas of the body.Background and Objectives: New therapy approaches for alopecia areata are emerging, with the goal of improving clinical outcomes. In this study, the effects of topical steroids against fractional Er: YAG laser followed by topical steroids in the treatment of alopecia areata will be compared.Methods: A total of 30 participants with alopecia areata were included in the study. Each patient's lesions were treated with one of two methods: topical clobetasol propionate or fractional Er: YAG laser followed by topical clobetasol propionate. SALT score, patient satisfaction, and dermoscopic imaging were used to evaluate therapeutic response.Results: Both treatment modalities showed a significant clinical improvement in alopecia areata with a statistically significant reduction in the SALT score. The SALT score was more evident in the laser-steroid group. On comparing the dermoscopy findings in both treated areas before and after treatment, a significant reduction was found regarding all dermoscopic findings of alopecia areata in both modalities.Combining fractional Er: YAG laser with topical steroids is found to be a safe treatment modality and more effective than topical steroids in alopecia areata.
Lysophosphatidic acid enhances P2X3 receptor-mediated currents in rat dorsal root ganglion neurons
Authors: Qiao Wen-Long , Li Qing , Hao Jia-Wei , Wei Shuang , Li Xue-Mei , Liu Ting-Ting , Qiu Chun-Yu , Hu Wang-Ping
Published: April 2022

Lysophosphatidic acid (LPA), a lipid metabolite, plays a role in both neuropathic and inflammatory pain through LPA1 receptors. P2X3 receptor has also been shown to participate in these pathological processes. However, it is still unclear whether there is a link between LPA signaling and P2X3 receptors in pain. Herein, we show that a functional interaction between them in rat dorsal root ganglia (DRG) neurons. Pre-application of LPA enhanced P2X3 receptor-mediated and α,β-methylene-ATP (α,β-meATP)-evoked inward currents in a concentration-dependent and voltage-independent manner. LPA shifted the concentration-response curve for α,β-meATP upwards, with an increase of 44.18 ± 8.74% in the maximal current response of P2X3 receptors to α,β-meATP in the presence of LPA. Enhancement of α,β-meATP-evoked currents by LPA was blocked by the LPA1 receptor antagonist Ki16198, but not by the LPA2 receptor antagonist H2L5185303. The LPA-induced potentiation was also prevented by intracellular application of either G- protein inhibitor or protein kinase C (PKC) inhibitor, but not by Rho inhibitor. Moreover, LPA increased the membrane excitability of DRG neurons, with a significant increase in the amplitude of the depolarization and the number of spikes induced by α,β-meATP in the presence of LPA. Finally, LPA exacerbated α,β-meATP- induced nociceptive behaviors in rats. These results suggested that LPA enhanced the functional activity of P2X3 receptors in rat primary sensory neurons through a mechanism that depends on the activation of the LPA1 receptor and its downstream PKC rather than Rho signaling pathway, indicating a novel peripheral mechanism underlying the sensitization of pain.
Polypoidal Choroidal Vasculopathy and Pachychoroid Neovasculopathy representing Different Manifestations of the Same Spectrum in the Same Patient: A Case Report
Authors: Andres Quiroz-Gonzalez Erick , A. Quiroz-Reyes Miguel , Graue-Wiechers Federico
Published: April 2022

Background: The pachychoroid spectrum comprises various clinical manifestations. There are three exclusive characteristics, all of which have unknown etiology and controversial pathogenesis: a pachychoroid, the presence of pachyvessels at the external choroid and inner choroidal attenuation.Purpose: The purpose of this study was to describe a patient with clinical and multimodal manifestations in the pachychoroid spectrum.Patients: Here, we describe a single patient with an unusual disease presenting as different clinical variants in both eyes simultaneously. The patient presented with acute visual loss in the right eye with massive hemorrhagic maculopathy and a chronic decrease in visual acuity and metamorphopsia in the left eye with pigmentary changes and subretinal fluid at the geometric center of the fovea. Method: The patient underwent a complete ophthalmological examination and multimodal imaging and was diagnosed with polypoidal choroidal vasculopathy (PCV) and pachychoroid neovasculopathy (PNV), two different manifestations of the same disease spectrum occurring simultaneously.Results: Due to the active nature of the disease, the patient received three doses of intravitreal antiangiogenic agents in each eye.Conclusion: The diagnosis of CNV should always be considered when macular subretinal fluid is present. Although many different degenerative etiologies were considered, such as pathological choroidal neovascularization due to age-related macular degeneration (AMD) and the pachychoroid spectrum, the evaluation of the choroid vasculature through swept-source or enhanced depth imaging OCT revealed the disease origin to be idiopathic. PCV and PNV are considered to represent a single end stage of the pachychoroid spectrum with different manifestations; the former presents with aneurysmatic characteristics, while the latter lacks this anomaly.
Function matters: Coronavirus cross-binding antibodies do not cross-neutralize
Authors: Farcet Maria R. , Schwaiger Julia , Karbiener Michael , Kreil Thomas R.
Published: April 2022

Background
During the current pandemic, the Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) neutralization capacity of the immunoglobulin (IG) supply has changed from undetectable for lots manufactured from plasma collected before the pandemic, to now highly potent.
Objective
As antibodies induced by exposure to or vaccination against Coronaviruses were shown to be cross-coronavirus reactive, it was of interest to understand whether SARS-CoV-2 neutralizing antibodies would result in increased functional IG potency also against seasonal Coronaviruses.
Methods
IG lots from US plasma collected before SARS-CoV-2 emerged and collected during the pandemic were analyzed by live virus neutralization assay for SARS-CoV-2 and seasonal Human coronaviruses (HCoVs) NL63 and OC43 neutralizing antibody content.
Results
Pre-pandemic IG showed no SARS-CoV-2 neutralizing antibody titers. However, IG lots produced from plasma of post-coronavirus disease 2019 (COVID-19) individuals exhibited robust anti-SARS-CoV-2 potency (1267 IU/ml) which further increased approximately 4-fold in pandemic IG lots reaching a mean titer of 5122 IU/ml. Nonetheless, neutralizing antibody potencies to the HCoVs NL63 and OC43 remained stable over this period, i.e., have not increased correspondingly.
Conclusion
The present results show that cross-Coronavirus-reactive antibodies are not cross-neutralizing, i.e., SARS-CoV-2 antibodies do not neutralize seasonal Coronaviruses NL63 and OC43.
An Enhanced Spectrum Allocation Algorithm for Secondary Users in Cognitive Radio Networks
Authors: Agarwal Sheenu , Vijay Sandip , Bagwari Ashish
Published: April 2022

Wireless communication is a vast field in order to do researches on transmitter sections, wireless mediums, receiver sections, repeaters as well as different antennas. The spectrum used for wireless communication is limited and the number of users is increasing day by day. To use the available spectrum efficiently cognitive radio were introduced in which different allocation schemes were proposed by the researchers. In this paper an enhanced artificial bee colony algorithm is proposed for predicting and sensing the channel of primary user which results in the efficient usage of the available spectrum via secondary users, the enhanced artificial bee colony algorithm first predict the channel allocated to primary user, thereafter it performs sensing of the channel due to which the false alarm probability reduced and overall throughput of the network increases. The proposed algorithm overcomes the drawbacks of modified traditional methodologies which were used only for sensing a channel and shows 11.8% more efficiency as compared to binary artificial bee colony algorithm. In future, the method for predicting the channel’s availability can be enhanced in order to maximize the probability of channel allocation to the secondary user.
Recurrent Radiculopathy Caused by Epidural Gas After Percutaneous TLIF spine surgery
Authors: Fares Ali Housein , Tonetti Jerome
Published: April 2022

An epidural gas (EG) containing pseudocyst is an unusual finding after surgery[1]. We presented a case of 72 years old woman presenting with recurrent radiculopathy due to epidural gas (EG) accumulation 2 weeks after percutaneous lumber spine surgery with posterior fixation and transforaminal lumbar interbody fusion (TLIF). After failure of Conservative treatment, the patient underwent revision spinal surgery to remove the gaseous cyst.
Transcriptome Analysis Reveals Drought Stress response Mediated by Biological Processes and Key Pathways in Gossypium Darwinii
Authors: Xu Cuilian , Ilyas Muhammad Kashif , Magwanga Richard Odongo , Lu Hejun , Khan M Kashif Riaz , Zhou Zhongli , Li Yujun , Kuang Zhengcheng , Ghafoor Abdul , Javaid Asif , Ibrar Danish , Wang Kunbo , Liu Fang , Chen Haodong
Published: April 2022

Background The allotetraploid wild cotton species, Gossypium darwinii, possess important traits of stress tolerance and good genetic stability that can be used for cotton improvement.Materials and Methods In this study, we analyzed the RNA-seq transcriptomes from leaves of G. darwinii seedlings with and without drought stress. A total of 86.7 million valid reads with an average length of 95.79 bp were generated from the two samples and 58,960 transcripts with a length of more than 500 bp were assembled. We searched the known proteins on the strength of sequence similarity; these transcripts were annotated with COG, KEGG and GO functional categories. According to gene expression abundance RPKM value, we carried out RT-qPCR analysis to determine the expression pattern of the obtained transcription factors.Results A total of 58,961 genes was differentially expressed (DEG), with 32,693 and 25,919 genes found to be upregulated and downregulated, respectively. Through gene ontology and KEGG pathways, the upregulated genes were found to associate with all the GO terms, molecular functions (MF), biological process (BP) and cellular components (CC), which are highly linked to enhancing drought stress tolerance.Conclusion The results obtained provide valuable information and a large number of transcripts, which can be exploited by cotton breeders in developing a more drought stress tolerant cotton germplasm.
Acute Mitral Valve Regurgitation Secondary to Papillary Muscle Rupture Due to Infective Endocarditis: A Case Report
Authors: Amirkhosravi Farshad , Abri Qasim Al , Lu Alexander J. , Nihum Lamees I. El , Eng Renee K. , von Ballmoos Moritz C. Wyler , Ramchandani Mahesh K.
Published: April 2022

Background: Papillary muscle rupture due to infective endocarditis is a rare event and proper management of this condition has not been described in the literature. Our case aims to shed light on treatment strategies for these patients using the current guidelines.Case Presentation: This case presents a 58-year-old male with acute heart failure secondary to papillary muscle rupture. He underwent an en bloc resection of his mitral valve with a bioprosthetic valve replacement. Specimen pathology later showed necrotic papillary muscle due to infective endocarditis. The patient was further treated with antibiotic therapy. He recovered well post-operatively and continued to do well after discharge.Conclusion: In patients who present with papillary muscle rupture secondary to infective endocarditis, clinical symptoms should drive the treatment strategy. Despite the etiology, early mitral valve surgery remains treatment of choice for patients who have papillary muscle rupture leading to acute heart failure. Culture-guided prolonged antibiotic treatment is vital in this category of patients, especially those who have a prosthetic valve implanted.
The Evolving Role of Nucleotide-binding Oligomerisation Domain-like Receptor Pyrin Domain 3 Inflammasome Activation in Vascular Endothelial Cells: A Review
Authors:   Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, United Kingdom, Abas Razif ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Basir Rusliza ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Mohd Thani Suryati ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Salihan Safuraa ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Saat Azmah ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Mohamad Zainal Nurul Hayati ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Mohamad Asri Siti Fadziyah ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Ab Razak Nur Izah ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Mohd Nor Nurul Huda ,   Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia, Kamaruddin Nur Aqilah ,   Department of Anatomy, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia
Published: April 2022

In the vascular wall, defence against pathogenic damage requires a group of monocytes, the endothelium, dendritic cells, macrophages and a subsequent involvement of pattern recognition receptors anticipating damage-associated molecular patterns (DAMPs) to initiate an innate immune response. The endothelium plays a crucial role in regulating the duration, location and extent of the inflammatory cascade to ensure a definitive immune defence. Molecular changes in the expression of chemokines and cell adhesion molecules ensure protective responses against infection and injury. The multiprotein oligomer complex nucleotide-binding oligomerisation domain (NOD)-like receptor pyrin domain 3 (NLRP3) inflammasome plays a key role in the activation of inflammatory processes in response to DAMPs and pattern-associated molecular patterns. As a result of NLRP3 inflammasome activation, caspase-1 is activated and interleukin-1β (IL-1β) is produced. Caspase-1 is the main mediator of inflammatory feedback to tissue injury, and it is engaged both in the initiation of the inflammatory response and in the induction of cell death. NLRP3 inflammasome promotes further inflammatory responses and pyroptosis in the vascular endothelium; thus, its optimum regulation is crucial in cardiovascular homeostasis. This review outlines our current perception of the role of NLRP3 in vascular endothelial cells.
Risk Prediction of Cerebral Infarction after Anterior Circulation Aneurysm Rupture in an Under-Equipped Centre
Authors:   Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Vinodh Vayara Perumall ,   Department of Neurosurgery, Queen Elizabeth 2 Hospital, Sabah, Malaysia, Ghani Abdul Rahman Izaini ,   Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Kandasamy Regunath ,   Department of Neurosciences, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Sellamuthu Pulivendhan ,   Department of Neurosurgery, Queen Elizabeth 2 Hospital, Sabah, Malaysia, Zenian Mohd Sofan ,   Department of Neurosurgery, Queen Elizabeth 2 Hospital, Sabah, Malaysia, Keowmani Thamron ,   Clinical Research Centre, Queen Elizabeth Hospital, Sabah, Malaysia
Published: April 2022

Background: Morbidity and mortality is high among aneurysm rupture patients. Despite surviving the initial rupture, morbidity is high as they suffer from vasospasm and cerebral infarction (CI). Most prediction tools for CI after aneurysmal subarachnoid haemorrhage (SAH) are complex and are not routinely available in all neurosurgical centres. Current therapies for prevention of CI are still debatable and selective usage among high-risk patients is advised. These factors necessitate a simple prediction model for identifying patients in the high risk group to initiate early preventive treatment of CI. Methods: Patients with anterior circulation aneurysm rupture who underwent surgical clipping were included. Demographic data and factors related to CI were collected to determine significance and were used to develop VINODH score (VS). Results: Two hundred patients were included with a median age of 51 years old. Multivariate analysis proved only four predictors were significant (P < 0.01) for developing CI. These predictors were used for the development of VS which was named after the main author and the model’s sensitivity was 79.0% and specificity was 83.0%. This highly predictive score (receiver operating characteristic [ROC]: 0.902) was internally validated. Conclusion: VS is a reliable tool for early identification of patients at risk of CI after aneurysmal SAH.
Predictors Affecting Diabetes Related Distress among Diabetes Patients
Authors:   Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia, Jia Yii Liew , Vanoh Divya ,   Dietetics Programme, School of Health Sciences, Universiti Sains Malaysia, Kelantan, Malaysia
Published: April 2022

Background: Diabetics experienced distress due to the disease. This distress may impact the quality of life and adherence to treatment by the diabetics. Thus, this study is aimed at identifying the factors affecting diabetes-related distress (DRD) among diabetic patients. Methods: A total of 100 diabetic subjects aged 18 years old and above were recruited. Data on socio-demographic data, anthropometry, hand grip strength (HGS) and body fat percentage were obtained. DRD was assessed using the Malay version of the 17-item diabetes distress scale (MDDS-17) questionnaire. Multiple linear regression was employed to identify the predictors of DRD and the significance value was set at P < 0.05. Results: The majority of the subjects had low DRD (93%). Univariate analysis revealed that higher DRD scores were correlated with being single, never exercising and having lower education level, body weight, body fat percentage, body mass index (BMI) as well as HGS (P < 0.05). However, further multivariate regression analysis revealed that only smoking and being single/ divorced/widow were the predictors of DRD. Conclusion: Predictors of DRD in this study were smoking and being either single/ divorced/widow. These factors must be taken into consideration during the medical management of diabetics in order to ensure more holistic management of the disease and the distress it caused.
Single-crystal elasticity of (Al,Fe)-bearing bridgmanite up to 82 GPa
Authors: Fu Suyu , Zhang Yanyao , Okuchi Takuo , Lin Jung-Fu
Published: April 2022

Thermoelastic properties of mantle candidate minerals are essential to our understanding of geophysical phenomena, geochemistry, and geodynamic evolutions of the silicate Earth. However, the lower-mantle mineralogy remains much debated due to the lack of single-crystal elastic moduli (Cij) and aggregate sound velocities of (Al,Fe)-bearing bridgmanite, the most abundant mineral of the planet, at the lower mantle pressure-temperature (P-T) conditions. Here we report single-crystal Cij of (Al,Fe)-bearing bridgmanite, Mg0.88Fe0.1Al0.14Si0.90O3 (Fe10-Al14-Bgm) with Fe3+/ΣFe = ~0.65, up to ~82 GPa using X-ray diffraction (XRD), Brillouin light scattering (BLS), and impulsive stimulated light scattering (ISLS) measurements in diamond-anvil cells (DACs). Two crystal platelets with orientations of (–0.50, 0.05, –0.86) and (0.65, –0.59, 0.48), that are sensitive to deriving all nine Cij, are used for compressional and shear wave velocity (νP and νS) measurements as a function of azimuthal angles over 200° at each experimental pressure. Our results show that all Cij of singe-crystal Fe10-Al14-Bgm increase monotonically with pressure with small uncertainties of 1–2% (±1σ), except C55 and C23, which have uncertainties of 3–4%. Using the third-order Eulerian finite-strain equations to model the elasticity data yields the aggregate adiabatic bulk and shear moduli and respective pressure derivatives at the reference pressure of 25 GPa: KS = 326 ± 4 GPa, µ = 211 ± 2 GPa, KS′ = 3.32 ± 0.04, and µ′ = 1.66 ± 0.02 GPa. The high-pressure aggregate νS and νP of Fe10-Al14-Bgm are 2.6–3.5% and 3.1–4.7% lower than those of MgSiO3 bridgmanite end-member, respectively. These data are used with literature reports on bridgmanite with different Fe and Al contents to quantitatively evaluate pressure and compositional effects on their elastic properties. Comparing with one-dimensional seismic profiles, our modeled velocity profiles of major lower-mantle mineral assemblages at relevant P-T suggest that the lower mantle could likely consist of about 89 vol% (Al,Fe)-bearing bridgmanite. After considering uncertainties, our best-fit model is still indistinguishable from pyrolitic or chondritic models.
Half-wormholes in nearly AdS$_2$ holography
Authors: Garcia-Garcia Antonio , Godet Victor
Published: April 2022

We find half-wormhole solutions in Jackiw-Teitelboim gravity by allowing the geometry to end on a spacetime D-brane with specific boundary conditions. This theory also contains a Euclidean wormhole which leads to a factorization problem. We propose that half-wormholes provide a gravitational picture for how factorization is restored and show that the Euclidean wormhole emerges from averaging over the boundary conditions. The wormhole is known to be dual to a Sachdev-Ye-Kitaev (SYK) model with random complex couplings. We find that the free energy of the half-wormhole is strikingly similar to that of a single realization of this SYK model. These results suggest that the gravitational path integral computes an average over spacetime D-brane boundary conditions.
The systematic assembly of prostate specific antigen electrochemical sensors based on asymmetric Co(II) phthalocyanines, graphitic quantum dots and an aptamer
Authors:   , Nxele Siphesihle Robin
Published: April 2022

The need for low-cost, efficient and simple diagnostic tools has led to more research going into this subject, with the aim of making such medical devices more accessible where they are needed. This has led to more researchers developing point-of-care devices for this purpose worldwide, by sensor fabrication. This thesis focuses on electrochemical sensor development for the early diagnosis of prostate cancer. It is common knowledge that prostate cancer is one of the most prevalent carcinomas that have claimed lives due to late diagnosis where even the most invasive treatments have failed. For this reason, development of early detection devices that can even be used in the comfort of home is necessary and quite crucial. Electrochemical sensors have gained much attention due to their ease of fabrication, cost effectiveness, simplicity, ease of use and high efficiency. Using nanocomposites as modifiers has also become popular as they provide greater stability and improve detection limits when used together with biomolecules. With that said, the work reported herein has combined nanocomposites of graphenebased quantum dots, gold nanoparticles, phthalocyanines and an aptamer in order to fabricate aptasensors for the electrochemical detection of prostate cancer biomarker. The aptamer is specifically designed to bind to the biomarker, and the nanocomposites are expected to enhance current output thus lowering detection limits and increasing stability and efficiency. Reproducible results are also expected. Prior to the detection of the prostate cancer biomarker, the quantum dots-phthalocyanine nanohybrids were used to detect L-cysteine, which is an amino acid, in order to verify the synergistic effects as electrode modifiers that lead to the enhancement of current output. This increase in current output is then v exploited for the improvement of aptasensor functionality upon incorporation of the aptamer, for the detection of prostate specific antigen. The research in this thesis has been carried out with the intention of contributing to the world of medical research, more so because of the ever-increasing need for medical care to become accessible to all and not only to those who can afford expensive technologies and treatments.
Flash sale and online impulse buying: Mediation effect of emotions
Authors: Martaleni Martaleni , Hendrasto Ferdian , Hidayat Noor , Alfandy Dzikri Amin , Nyoman Kerti Yasa Ni
Published: April 2022

Flash sale (FS) is a marketing strategy that is widely used and developed in sales through e-commerce. The implementation of the FS strategy is to provide discounts or special propositions on products offered within a certain time limit. Time restrictions aim to encourage consumers’ emotions to make impulse buying (IB). This study examines the effect of consumer emotions as a mediating variable on IB among Shoppee consumers in Indonesia caused by FS activities that are not carried out on certain important days. The required data were collected through the distribution of online questionnaires to respondents who, in the last three months, had made transactions through Shoppee e-commerce platform. A total of 150 questionnaires are analyzed using PLS-SEM. The results of the analysis show that the flash sale strategy carried out by the Shoppee e-commerce platform in Indonesia has a direct effect on increasing consumer emotions. This means that the higher the intensity of the FS promotion, the stronger the influence on consumer emotions. Emotions increase IB. FS has no significant effect on increasing IB. Subsequent findings show that FS indirectly has a positive and significant effect on IB through emotions. In other words, this study proves that the emotions are a mediating variable in online IB. This study is helpful for companies in developing appropriate strategies for their promotions in utilizing consumers’ impulse buying behavior by using strategies that trigger consumers’ emotions.
“Best dentist ever” — evaluation strategies in the headlines of Danish and German positive online consumer reviews
Authors:   Adam Mickiewicz University, Sobkowiak Mikołaj , Waliszewska Karolina ,   Adam Mickiewicz University
Published: April 2022

Over the last few decades, computer-mediated communication (CMC) has become a significant element of our reality and, subsequently, an item of interest for researchers within many disciplines. CMC’s rapid development has resulted in the emergence of new, multimodal means of expression, text genres, and communication styles. Among the new genres are online consumer reviews, which impact the behavior of online consumers to a large extent, but are also valuable for linguistic researchers due to their structure, content, and functions. The headlines of online consumer reviews seem to be of particular importance, although they have not received much attention in linguistic research so far. This paper offers a contrastive analysis of 200 headlines of positive online customer reviews for Danish and German dental care providers. Because of the way consumer reviews are displayed and consumed online, their headlines can be treated as separate texts and are analyzed as such throughout the paper. The investigation’s overall goal is twofold: (i) to identify the basic communicative functions of the headlines, and (ii) to describe the linguistic means employed to express those functions. The analysis seeks to find potential similarities and differences between the headlines of positive reviews written in Danish and German. The findings show that there is little variation between the two subsets of the analyzed corpus as far as communicative functions and employed linguistic means are concerned. This may indicate that the identified features could be treated as characteristic of the genre rather than language-specific.
Word and truth — a look at Johannes V. Jensen’s journalism. Part 2
Authors: Jørgensen Aage
Published: April 2022

Since the establishment of the Johannes V. Jensen Centre at Aarhus University in 1993, studies of the Nobel Prize winner have shifted from the biographical to the textual. At the same time, the publication especially of early works with critical commentary has intensified. The present article traces some themes throughout a half-century of Jensen’s journalism, which was first assembled in book form in 2014 under the title Word and Truth. The material brings more nuance to impressions of the poet’s opinions and positions, in part because the anthologizing of his journalistic works has, until now and for good reason, skimmed only the cream. Now the dregs are considered as well, and even this portion of Jensen’s work impresses with its linguistically seductive energy and fascinating images. Jensen himself agreed to have most of the articles reprinted, and they were included in the so-called mythic volumes. Jensen regarded myth as a special genre, his own reply in all modesty to what H. C. Andersen had done for the fairy tale. Jensen’s journalism spans also biographically, from the poet’s native soil in Jutland, to distant parts of the world, with the capital as well as rural Tisvilde as important stops along the way. The poet’s efforts to protect nature and implied archeological interests (not only in a Danish context) are reflected in a number of articles. Just as meaningful, but modernity-oriented, is an enthusiasm for technical development, machinery, and traffic on land, sea, and air. Life’s origins and the development of the species are viewed with a Darwinist perspective. The present article’s second part deals with Jensen’s tradition-bound understanding of the relationship between the sexes and, in that connection, his fear of “sexual confusion” often mentioned, most painfully in the 1907 intimidation of his colleague Herman Bang. Finally, attention is given to the part of Jensen’s journalism that portrays his own travels and his writings on other’s contributions to the genre of travel literature.
Pizza “Grandiosa” and Norwegian culinary traditions
Authors:   St. Petersburg State University, Livanova Aleksandra
Published: April 2022

When it comes to the harmful effects of globalization on Norwegian traditional values, one often draws on the example of the pizza “Grandiosa” phenomenon. Not only the daily assortment of dishes, but also traditional Christmas fare gave way to the “Grandiosa.” Experts in the field of culture and cultural heritage show much interest in this phenomenon; it is also addressed in Norwegian fiction, mostly as something ignoble. The change in Norwegian tastes that happened with this pizza is called the “revolution in eating habits.” Researchers render it impossible to find a rational explanation of this phenomenon. However, the traditional Norwegian cuisine is rather ascetic, with preference to universal dishes, which is easily explained by difficult natural conditions. And in our days, the lack of time dictates the extra need for universal dishes that combine components of the first and the second, as well as a side dish, and which do not require much time for cooking. Frozen pizza is perfect in that regard, and kebabs, tapas, and tacos followed it to the Norwegian table. Pizza was just the first to announce the era of food globalization, and it served as a conduit of globalization in Norwegian cuisine.
To the Question of Legal Regulation of Organization and Experimental Legal Regimes in the Sphere of Innovative Technologies
Authors:   Irkutsk state University, Chagin I.B.
Published: April 2022

The article is devoted to the order of organization and implementation of experimental legal regimes in the Russian Federation and foreign countries. The author investigates modern domestic and foreign law enforcement practice of establishing experimental legal regimes in the field of innovative technologies, and using the example of Russian legislation, the mechanism of establishing experimental legal regimes presents the data on initiative proposals in this direction. As criteria for the analysis the peculiarities of normative-legal regulation of the procedure for establishing experimental legal regimes; peculiarities of the circle of persons and the territory of experimental legal regimes; peculiarities of determining the authorized officials and bodies that make decisions on the establishment of experimental legal regimes are highlighted. The question of understanding the order of experimental legal regimes establishment as either a law-making initiative or an administrative procedure is raised. The author substantiates the value of experimental legal regimes, which lies in the possibility to identify the negative consequences of the introduction of innovative technologies on a limited scale. The problem of establishing a balance between the rights and obligations of authorized bodies and persons taking the initiative to establish experimental legal regimes is outlined. The need for theoretical and legal research on the role of the state in the regulation of social relations associated with experimental legal regimes is pointed out.
PARTICIPATION OF ANATOLY FEDOROVICH KONI IN THE FORMATION OF THE EMPIRE CRIMINAL LAW POLICY IN 1906–1917
Authors:   Saint Petersburg Institute (Branch), All-Russian State University of Justice, Kodintsev A.Ya. , Rybin D.V. ,   Saint Petersburg Institute (Branch), All-Russian State University of Justice
Published: April 2022

As an active participant of special commissions on the development of criminal laws of the Empire, Anatoly Fedorovich Koni, nevertheless, in the last quarter of the XIX century, practically did not touch upon the issues of the criminal law theory (the exception was the work of the young lawyer in 1866). The practical experience gained by the famous senator allowed him to move into the sphere of theoretical jurisprudence. Being a member of the State Council Kony took an active part in the development of the state criminal policy and at the beginning of the 20th century, he did not only write the works on the criminal law theory, but also stated his objectives of the contemporary criminal policy. A.F. Koni subjected outdated norms in the field of criminal law to harsh criticism, noted their ineffectiveness and often – meaninglessness. His criticism of the outdated norms influenced the procedure of their abolition in the early twentieth century – at the time of the adoption and enactment of the new Criminal Code of the Empire. The criminal and legal views of Anatoly Fedorovich Koni during the specified period were not the subject of special study by scientists, since only a small part of his works on criminal law was published. Using archival materials and little-known publications, we consider the contribution of A.F. Koni to the development of criminal law and criminal law policy of the Russian state in the period between the two revolutions.
ositions of the Constitutional Court of the Russian Federation in the Housing Sphere: Problems of Implementation
Authors:   Irkutsk Institute (Branch), All-Russian State University of Justice, Suslova S.I.
Published: April 2022

The article expresses the hypothesis that non-execution of the decisions of the Constitutional Court of the Russian Federation in the housing law sphere is often predetermined by the political and legal moments associated with the need to choose between the protection of economic turnover and housing rights of citizens. Often the apparent fair decision aimed at taking into account the social importance of housing relations, on the scale of public policy can lead to serious adverse economic consequences. The hypothesis was confirmed when analyzing several fundamental decisions of the Constitutional Court of the Russian Federation in the sphere of regulation of housing relations, including the position on the possibility to sell residential premises in which underage family members of the owner reside and who do not have the right of ownership, the position on property immunity with regard to the only residential premises, as well as the position on the execution major repairs by a public authority (former landlord of the residential premises). It is concluded that the most effective are those decisions of the Constitutional Court of the Russian Federation, in which this choice is made unambiguously, without any attempts to reconcile these two areas.
Analysis of precipitation characteristics and changes of drought and flood disasters on Anhui Province between 1961 and 2020, based on time series
Authors: Zhang Xianqi , Zhao Dong , Zhao Yue , Wen Yihao
Published: April 2022

The analysis of annual precipitation evolution characteristics is of great value and significance for revealing the spatial and temporal variation patterns of regional precipitation, water resources development and utilization, short-term climate, drought, flood disaster prediction, etc. The Mann-Kendall (MK) mutation test, cumulative distance level method, and Morlet wavelet analysis were used to analyze the precipitation evolution in Anhui Province from 1961 to 2020. The results showed that the average annual temperature and precipitation in Anhui Province showed a significant increasing trend during 1961–2020, with warming and humidification. 1994 was the year of abrupt climate change in Anhui Province, and the temperature after the abrupt change was 2.10 times that before the abrupt change. El Niño-Southern Oscillation (ENSO) has a synchronized resonance cycle with droughts and floods in Anhui Province at 5.8 a. The annual scale of ENSO events is an important theoretical support for regional drought and flood warnings. The chance of drought and flooding in Anhui Province is greater than 50% in the year of ENSO event or two years after the event, and the year of ENSO event or the year after is prone to drought and flooding, so we should strengthen the flood and drought warning, disaster prevention and mitigation.
Synthetic Utility of Aminomercapto[1,2,4]triazoles in the Preparation of Fused
Triazoles
Authors: Riyadh Sayed M. , Abolibda Tariq Z. , Sayed Abdelwahed R. , Gomha Sobhi M.
Published: April 2022

Triazoles and their fused derivatives are regarded as one of the most pharmacologically
significant pillars due to their potent, broad, and numerous activities. This current review
presents recent progress in the synthetic utility of 3-substituted-4-amino-5-mercapto[1,2,4]-
triazoles as building blocks for a diverse range of fused [1,2,4]triazoles with pharmacological
interest eg. pyrazolo-triazoles, triazolo-thiadiazoles, triazolo-triazoles, triazolo-thiadiazines,
triazolo-triazines, triazolo-tetrazines, triazolo-thiadiazepines, and others. The biological activity
of some triazoles and their fused derivatives are also presented. This suggests that triazoles
can be particularly promising synthons in synthesis of functionalized heterocyclic compounds
used in the design of novel, highly effective pharmaceuticals with a broad spectrum of bioresponses.
All of these topics are drawn in this review from the period from 2000 to 2020.
Temporal Speech Parameters Detect Mild Cognitive Impairment in Different
Languages: Validation and Comparison of the Speech-GAP Test® in
English and Hungarian
Authors: Kálmán János , Devanand Davangere P. , Gosztolya Gábor , Balogh Réka , Imre Nóra , Tóth László , Hoffmann Ildikó , Kovács Ildikó , Vincze Veronika , Pákáski Magdolna
Published: April 2022

Background:

The development of automatic speech recognition (ASR) technology allows
the analysis of temporal (time-based) speech parameters characteristic of mild cognitive impairment
(MCI). However, no information has been available on whether the analysis of spontaneous speech can
be used with the same efficiency in different language environments.

Objective:

The main goal of this international pilot study is to address the question of whether the
Speech-Gap Test® (S-GAP Test®), previously tested in the Hungarian language, is appropriate for and
applicable to the recognition of MCI in other languages such as English.

Method:

After an initial screening of 88 individuals, English-speaking (n = 33) and Hungarianspeaking
(n = 33) participants were classified as having MCI or as healthy controls (HC) based on Petersen’s
criteria. The speech of each participant was recorded via a spontaneous speech task. Fifteen
temporal parameters were determined and calculated through ASR.

Results:

Seven temporal parameters in the English-speaking sample and 5 in the Hungarian-speaking
sample showed significant differences between the MCI and the HC groups. Receiver operating characteristics
(ROC) analysis clearly distinguished the English-speaking MCI cases from the HC group based
on speech tempo and articulation tempo with 100% sensitivity, and on three more temporal parameters
with high sensitivity (85.7%). In the Hungarian-speaking sample, the ROC analysis showed similar
sensitivity rates (92.3%).

Conclusion:

The results of this study in different native-speaking populations suggest that changes in
acoustic parameters detected by the S-GAP Test® might be present across different languages.
Dysregulated Epigenetics of Chordoma: Prognostic Markers and Therapeutic
Targets
Authors: Shukla Hem , Tu Kevin , Lee Sang , Roy Sanjit , Sawant Amit
Published: April 2022

Chordoma is a rare, slow-growing sarcoma that is locally aggressive and typically resistant
to conventional chemo- and radiotherapies. Despite its low incidence, chordoma remains a clinical
challenge because therapeutic options for chordoma are limited, and little is known about the molecular
mechanisms involved in resistance to therapies. Furthermore, there are currently no established predictive
or prognostic biomarkers to follow disease progression or treatment. Whole-genome sequencing
of chordoma tissues has demonstrated a low-frequency mutation rate compared to other cancers.
This has generated interest in the role of epigenetic events in chordoma pathogenesis. In this review,
we discuss the current understanding of the epigenetic drivers of chordoma and their potential applications
in prognosis and the development of new therapies.
Premature Infants have no Higher Risk of Atopy and Respiratory Functions Compared to Control at 4-6 Years of Age
Authors: Satar Mehmet , Güven Tuğçe , Şimşek Hüseyin , Ufuk Altıntaş Derya
Published: April 2022

Aims:

This study aimed to evaluate the respiratory functions and atopy conditions of preterm
infants treated with aminophylline or caffeine for apnea in NICU in early childhood.

Materials and Methods:

This is a retrospective cohort study. In this study, 27 patients aged 4 to 6
years hospitalized in NICU for prematurity and 26 healthy children were included. The subjects
were evaluated for fx5, phadiatope, total IgE levels, skin tests, and respiratory function tests.

Results:

There was no statistically significant difference among groups in terms of fx5, phadiatope,
total IgE levels, and skin test results. Moreover, no statistically significant difference was found
among the groups in terms of FVC, FEV1, FEV1/ FVC, PEF, MEF75, MEF50, MEF25, and MEF25-75
values in respiratory function tests. Preterm neonates with bronchopulmonary dysplasia (BPD) had
higher FEV1 values compared to ones without BPD (p=0.02).

Conclusion:

Preterm infants treated with aminophylline or caffeine did not have a higher risk of
atopy and had similar respiratory function tests compared to healthy infants at 4-6 years old. However,
FEV1 values were higher in infants with BPD. These results suggested that respiratory functions
could be affected in the long-term follow-up of premature infants with BPD.
Evaluation of thein vivoAntioxidant and Antihemolytic Potential ofPeganum harmalaMethanolic Seed Extract
Authors: Djarmouni Meriem , Adjadj Moufida , Baghiani Abderrahmane
Published: April 2022

Background:

Peganum harmala L. is a medicinal herbal plant widely used in traditional medicine in various countries, especially in Algeria. This study aimed to carry out the extraction of P. harmala seeds and to evaluate the antioxidant and antihemolytic potentials of 100 mg/kg methanol extract in plasma, blood, and liver of Swiss albino mice.

Methods:

The antioxidant capacity of the plasma samples was performed using free radical scavenging (DPPH assay) and reducing power activities. However, the antihemolytic effect of methanol extract was measured in the blood induced by tBH. The biomarkers of oxidative stress were evaluated in liver tissues by measuring the activity of catalase enzyme (CAT), and the level of GSH and MDA products.

Results:

The results showed that 100 mg/kg of MOHE did not show any significant changes in plasma antioxidant capacity by DPPH assay when we compared with a control group (32.70 ± 4,45 %), however, the reducing power capacity of plasma is remarkable in methanolic extract and VitC groups. Fifty percent of red blood cell lysis was calculated (HT50) for measuring the antihemolytic effect, the results showed that MOHEhad a protective effect against RBC hemolysis with HT50 = 78,51 ± 11,32 min. In addition, MOHE increases the activity of CAT, GSH levels whereas it decreases the MDA levels in the homogenate liver, which demonstrates that MOHE inhibits the lipid peroxidation in the liver.

Conclusion:

This plant has a strong pharmacological power due to its secondary metabolite. However, its uses for therapeutic purposes is not without danger and exposes the risk of intoxication.