bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune system activation and cognitive impairment in arterial hypertension
Authors: Schreiber Stefanie , Arndt Philipp , Morton Lorena , Garza Alejandra P. , Müller Patrick , Neumann Katja , Mattern Hendrik , Dörner Marc , Bernal Jose , Vielhaber Stefan , Meuth Sven G. , Dunay Ildiko R. , Dityatev Alexander , Henneicke Solveig
Published: November 2024

Chronic arterial hypertension disrupts the integrity of the cerebral microvasculature, doubling the risk of age-related dementia. Despite sufficient antihypertensive therapy in still a significant proportion of individuals blood pressure lowering alone does not preserve cognitive health. Accumulating evidence highlights the role of inflammatory mechanisms in the pathogenesis of hypertension. In this review, we introduce a temporal framework to explore how early immune system activation and interactions at neurovascular-immune interfaces pave the way to cognitive impairment. The overall paradigm suggests that prohypertensive stimuli induce mechanical stress and systemic inflammatory responses that shift peripheral and meningeal immune effector mechanisms toward a proinflammatory state. Neurovascular-immune interfaces in the brain include a dysfunctional blood-brain barrier, crossed by peripheral immune cells; the perivascular space, in which macrophages respond to cerebrospinal fluid- and blood-derived immune regulators; and the meningeal immune reservoir, particularly T cells. Immune responses at these interfaces bridge peripheral and neurovascular unit inflammation, directly contributing to impaired brain perfusion, clearance of toxic metabolites, and synaptic function. We propose that deep immunophenotyping in biofluids together with advanced neuroimaging could aid in the translational determination of sequential immune and brain endotypes specific to arterial hypertension. This could close knowledge gaps on how and when immune system activation transits into neurovascular dysfunction and cognitive impairment. In the future, targeting specific immune mechanisms could prevent and halt hypertension disease progression before clinical symptoms arise, addressing the need for new interventions against one of the leading threats to cognitive health.
Ciliopathy organoid models: a comprehensive review
Authors: Kuzinska Matylda Zofia , Lin Sally Yuan-Yin , Klämbt Verena , Bufler Philip , Rezvani Milad
Published: November 2024

Organoids allow for phenotypical recapitulation of ciliopathies, including excessive cyst formation and fibrogenic signaling. To this day, diseases of the kidney, the airway, the liver, and the retina have been successfully modeled “in the dish” with the help of multicellular three-dimensional cultures, organoids-on-a-chip, suspension cultures, and organoid engraftment models in animals. Moreover, multiple platforms have been tested in the context of drug assays, revealing several novel potential therapeutic candidates.
β3-adrenergic agonist counters oxidative stress and Na+-K+ pump inhibitory S-glutathionylation of placental cells: implications for preeclampsia
Authors: Liu Chia-Chi , Zhang Yunjia , Kim Yeon Jae , Hamilton Elisha J. , Xu Bei , Limas Jane , McCracken Sharon A. , Morris Jonathan M. , Makris Angela , Hennessy Annemarie , Rasmussen Helge H.
Published: November 2024

H/R-induced oxidative stress and deficient NO-dependent placentation are features of preeclampsia, yet nonspecific antioxidants and NO donors are ineffective. Here, activation of the microdomain-confined signaling pathway with an agonist for the eNOS-coupled β3-AR eliminates inhibitory glutathionylation of the Na+-K+ pump’s β1 subunit, uncoupling of eNOS, and activation of NADPH oxidase that are sources of H/R-induced oxidative stress. The agonist also eliminates H/R-induced inhibition of trophoblast migration and their integration into an endothelial network.
Comparative Assessment of Simoa and Lumipulse for Measuring Serum Neurofilament Light Chain in Multiple Sclerosis Patients
Authors: Gasque-Rubio Raquel , Cubas-Nuñez Laura , Tortosa-Carreres Jordi , Forés-Toribio Lorena , Castillo-Villalba Jéssica , Carratalá-Boscá Sara , Alcalá-Vicente Carmen , Quintanilla-Bordás Carlos , Gorriz David , Gascón-Gimenez Francisco , Cervera-Ygual Guillermo , Dominguez-Morán José Andrés , Carcelén-Gadea María , Laiz Marro Begoña , Casanova Bonaventura , Pérez-Miralles Francisco
Published: November 2024

Background: The assessment of serum neurofilament light chain (sNfL) is increasingly significant in the field of neurology. In multiple sclerosis (MS), it proves valuable as a marker for monitoring disease activity and treatment response.

Objective: To compare the Simoa and Lumipulse platforms for measuring sNfL and to establish age‐specific reference ranges within a substantial cohort of individuals diagnosed with MS.

Methods: Two hundred sixty‐one sNfL measurements from a cohort of 229 MS patients were analyzed with Simoa and Lumipulse. Reference ranges for sNfL were established for three age groups (18–39 years, 40–59 years, and > 60 years) selecting data from 166 patients with stable relapsing–remitting MS.

Results: While sNfL levels correlated between assays, Lumipulse exhibited values higher than Simoa. Passing–Bablok’s analysis confirmed linearity between the two datasets, and the Bland–Altman comparison further supported the agreement between the methods. Analyzing reference ranges for sNfL across three age groups in stable RRMS patients revealed significant differences between the groups on each of the platforms. Although the values followed the same trend, each technology utilized distinct reference ranges.

Conclusion: Simoa and Lumipulse platforms proved equally effective in monitoring patients with MS. The enhanced accessibility of the Lumipulse platform facilitates the expansion of research on sNfL as a biomarker for monitoring MS, thus offering promising opportunities for broader accessibility and advancement in this field.
Construction of the Information Dissemination Model and Calculation of User Influence Based on Attenuation Coefficient
Authors: Guo Lin , Zhang Su , Liu Xiaoying
Published: November 2024

Users’ online activities serve as a mirror, reflecting their unique personas, affiliations, interests, and hobbies within the real world. Network information dissemination is inherently targeted, as users actively seek information to facilitate precise and swift communication. Delving into the nuances of information propagation on the Internet holds immense potential for facilitating commercial endeavors such as targeted advertising, personalized product recommendations, and insightful consumer behavior analyses. Recognizing that the intensity of information transmission diminishes with the proliferation of competing messages, increased transmission distances, and the passage of time, this paper draws inspiration from the concept of heat attenuation to formulate an innovative information propagation model. This model simulates the “heat index” of each node in the transmission process, thereby capturing the dynamic nature of information flow. Extensive experiments, bolstered by comparative analyses of multiple datasets and relevant algorithms, validate the correctness, feasibility, and efficiency of our proposed algorithm. Notably, our approach demonstrates remarkable accuracy and stability, underscoring its potential for real‐world applications.
Effect of Hydrogen Sulfide on Sympathoinhibition in Obese Pithed Rats and Participation of K+ Channel
Authors: Gomez Carolina B. , Sánchez-López Araceli , Carvajal Karla , Centurión David
Published: November 2024

Elevated blood pressure is the leading metabolic risk factor in attributable deaths, and hydrogen sulfide (H2S) regulates vascular tone and blood pressure. Thus, this study aims to evaluate the mechanism by which NaHS (H2S donor) produces inhibition of the vasopressor sympathetic outflow in obese rats. For that purpose, animals were fed a high‐fat diet (HFD) (60% calories from fat) for 12 weeks. They were anesthetized, pithed, and cannulated to evaluate the role of the potassium channel on NaHS‐induced sympathoinhibition. Animals received selective electrical stimulation of the vasopressor sympathetic outflow, an intravenous (i.v.) administration of (1) tetraethylammonium (TEA, non‐selective K+ channel blocker, 16.5 mg/kg), (2) 4‐aminopyridine (4‐AP, KV channel blocker, 5 mg/kg), (3) barium chloride (BaCl2, KIR channel blocker, 65 μg/kg), (4) saline solution (vehicle of TEA, 4‐AP, and BaCl2, 1 mL/kg), (5) glibenclamide (KATP channel blocker, 10 mg/kg), and (6) glibenclamide vehicle (DMSO + glucose 10% + NaOH, 1 mL/kg), and then a 310 μg/kg·min NaHS i.v. continuous infusion. We observed that (1) NaHS produced inhibition of the vasopressor sympathetic outflow and (2) the sympathoinhibitory effect by NaHS was reversed by the KIR channel blocker, BaCl2, in obese rats. The above data suggest that the potassium channel could be involved in the sympathoinhibition induced by NaHS.
Angiotensin Receptor–Neprilysin Inhibitor in Heart Failure Patients With Renal Dysfunction
Authors: Zhu Xiaogang , Li Xialing , Zhu Lingxuan , Tong Zichuan , Xu Xiuying
Published: November 2024

Heart failure (HF) and renal dysfunction often coexist and interact in many complex and bidirectional pathways, leading to detrimental effects on patient outcomes. The treatment of HF patients with renal dysfunction presents a significant clinical challenge. Interestingly, sacubitril/valsartan, an angiotensin receptor–neprilysin inhibitor (ARNI), may have beneficial effects on cardiac and renal outcomes in patients with HF with reduced ejection fraction, particularly by slowing the rate of decrease in the estimated glomerular filtration rate compared to a single angiotensin–converting enzyme inhibitor. Recently, more reports have emphasized the renal protection of sacubitril/valsartan in patients with HF. In HF patients with renal dysfunction, however, there is no strong evidence supporting the use of sacubitril/valsartan to reduce the absolute risk of hyperkalemia and worsening renal function; therefore, the administration of ARNI requires a careful balance between the benefits and risks. Furthermore, the lack of evidence‐based management highlights the importance of an individualized approach based on published experience and multidisciplinary collaborations, as well as underlines the need for in‐depth studies investigating the underlying mechanisms in cardiorenal interactions with a focus on treatments.
Severe Antiphospholipid Syndrome and Diffuse Glomerulonephritis After Adalimumab Treatment in a Patient With Ulcerative Colitis
Authors: Rivera-Burgos Ileana , Vilá Luis M.
Published: November 2024

Tumor necrosis factor alpha inhibitors (TNFi) are biological drugs used worldwide to treat various autoimmune disorders. Paradoxically, TNF‐α antagonists can also induce autoimmune diseases being systemic vasculitis, systemic lupus erythematosus, and psoriasis, the most common. We present a 22‐year‐old woman with ulcerative colitis (UC) who was started on adalimumab 40 mg subcutaneously every 2 weeks. After two doses of adalimumab, she developed gangrene of all toes and acute kidney injury requiring hemodialysis. Skin biopsy showed thrombi in the small vessels of the dermis. Renal biopsy disclosed diffuse proliferative glomerulonephritis (GN) and acute tubulointerstitial nephritis. Serologic work‐up showed positive IgG anticardiolipin (ACL) antibodies and low C3 levels. Antinuclear, anti‐dsDNA, anti‐Smith, anti‐SSA, anti‐SSB, anti‐RNP, antineutrophil cytoplasmic antibodies, ACL (IgA and IgM), and anti‐β2‐glycoprotein I (IgG, IgM, and IgA) antibodies were not elevated. Lupus anticoagulant test and cryoglobulins were negative. Adalimumab was discontinued, and she was treated with enoxaparin, intravenous (IV) methylprednisolone pulse, IV cyclophosphamide, and plasmapheresis followed by maintenance therapy with warfarin, prednisone, azathioprine, and hydroxychloroquine. She did not have further thrombotic events, and the acute kidney injury completely resolved. ACL IgG antibodies decreased to normal levels, and repeated tests were negative. After 7 years, anticoagulation and immunosuppressive drugs were discontinued. During a follow‐up of 24 months, she remained in complete clinical remission. This report highlights the occurrence of autoimmune disorders induced by TNFi. Thus, careful monitoring of adverse immune reactions to TNFi is highly recommended.
Effects of Diet Supplemented With Hydrolyzable Tannin on the Growth Performance, Antioxidant Capacity, and Muscle Nutritional Quality of Juvenile Mastacembelus armatus
Authors: Xue Xiaowen , Chen Yiman , Yu Zhide , Feng Yuwei , Zhang Linan , Han Chong , Yin Xiaoli , Lu Baoyue , Shu Hu
Published: November 2024

In this study, four groups of diet were prepared, with eel commercial diet without hydrolyzable tannin (HT) as the control group (H0), and the other three groups were fed with diet containing 0.05% (H1), 0.1% (H2), and 0.2% (H3) doses of HT to juvenile Mastacembelus armatus with an initial body weight of (0.40 ± 0.005) g. Juvenile fish in all groups were fed continuously for 60 days. Growth indices, hepatopancreatic antioxidant enzymes, biochemical indices (including total superoxide dismutase [T‐SOD], catalase [CAT], malondialdehyde [MDA], total antioxidant capacity [T‐AOC], alanine aminotransferase [ALT], aspartate aminotransferase [AST], alkaline phosphatase [AKP], and triglyceride [TG]), the content of muscle amino acids and fatty acids, stomach and intestine enzyme activities (pepsin, amylase, lipase), and genes expressions were evaluated. The results showed that 0.1% HT significantly improved the growth performance, hepatopancreatic antioxidant capacity, as well as muscle quality and lipase activity of juvenile M. armatus. In summary, the optimal addition level of HT in the diet of juvenile M. armatus is 0.1%, which helps to improve aquaculture efficiency and improve the muscle quality of M. armatus. However, the long‐term effects of feeding HT on M. armatus and its physiological reaction mechanism need to be further explored.
Study on the Conductivity and Pressure Sensitivity Performance of Carbon Fiber Geopolymer
Authors: Yang Fei , Qiao Mengjie , Li Linchang , Hai Ran , Hui Cun
Published: November 2024

This study uses slag (SL), fly ash (FA), and carbon fiber (CF) as raw materials to fabricate a conductive geopolymer, exploring the impact of CF content on its workability and mechanical performance. The conductivity and pressure sensitivity performance of the geopolymer are tested using an embedded four‐electrode method. The findings indicate that the incorporation of CF reduces the fluidity of the geopolymer and shortens its setting time. With the increase of CF content, the compressive strength increases first and then decreases, while the flexural strength increases gradually when the CF content is 0.2 v%, the percolation threshold is reached, and the resistivity is 268 Ω·cm. The geopolymer exhibits good pressure sensitivity performance under both monotonic and cyclic loading. With a stress amplitude of 15 MPa and a loading rate of 1 kN/s, the specimen’s resistance change rate can reach −38.4%. The pressure sensitivity performance is optimal, with good repeatability and stability.
Durability and Efficacy of Faricimab in Treatment‐Resistant Retinal Edema Utilizing “Real‐World” Dosing Regimens
Authors: Savant Shravan V. , Kwan James T. , Barouch Fina , Chang Jeffrey , Ramsey David J. , Marx Jeffrey , Blaha Gregory , Klein-Mascia Kendra
Published: November 2024

Purpose: To retrospectively analyze clinical outcomes of patients with “treatment‐resistant” neovascular age‐related macular degeneration or diabetic macular edema who were switched to intravitreal faricimab injections (IFIs) using a “real‐world” treat‐and‐extend (TAE) protocol.

Methods: Seventy‐one eyes from 62 patients receiving antivascular endothelial growth factor injections were evaluated before and after switching to IFI. Demographic and clinical data were collected. Primary endpoints were treatment interval extension and presence of intraretinal or subretinal fluid on spectral‐domain optical coherence tomography (OCT) after switching to IFI. Secondary endpoints included best‐corrected visual acuity, average OCT central subfield thickness, and presence of a pigment epithelium detachment and pigment epithelium detachment height.

Results: The average treatment interval after switching to IFI significantly increased from 37.6 ± 10.8 days to 45.2 ± 16.6 days (p = 0.0016). At the last follow‐up, 35% of eyes were able to achieve a fluid‐free status post‐IFI. A chi‐square test of independence validated this finding by showing a significant difference in the OCT findings trending towards less or no fluid on follow‐up (X2 [3, N = 71] = 13.0705; p = 0.0003). The average central subfield thickness decreased from 327.2 ± 89.1 μm to 294.8 ± 86.5 μm (p = 0.0294). Best‐corrected visual acuity, intraocular pressure, pigment epithelium detachment presence, and height had no significant difference after switching to IFI.

Conclusions: In “treatment‐resistant” patients receiving anti‐VEGF therapy for neovascular age‐related macular degeneration or diabetic macular edema, switching to IFI in a “real‐world” TAE protocol led to statistically significant improvements in treatment interval and retinal fluid on spectral domain OCT.
The Impact of Landfill Operations on Borehole Water Quality
Authors: Sackey Lyndon N. A. , Kwablah Rita , Agyemang Lawrencia S. Y.
Published: November 2024

Water is crucial for life, and although groundwater is considered safe, it can degrade due to inadequate source protection and inefficient resource management. The aim of the study was to assess the impact of landfill operations on water quality from selected landfill sites. Spectrometry analytical techniques were used to assess the physicochemical parameters of the samples. The study found that while Salmonella was absent in most samples, E. coli and total coliforms were present, making the water unsafe for domestic use. Although turbidity, pH, temperature and other parameters were within acceptable GSA/WHO levels, total coliform and E. coli raise concerns about faecal contamination and potential health risks. Cadmium was absent in all samples, but chromium, lead, arsenic and mercury were detected. These heavy metals could pose health hazards to consumers. The samples showed no risk of noncarcinogenic and carcinogenic risk to consumers, but then there is a potential health risk to consumers over time due to bioaccumulation. Regular monitoring and periodic assessments are recommended to ensure water safety. Proper waste management practices in landfill areas can minimize potential impacts on water quality, highlighting the need for continuous monitoring and assessment. The municipal authorities can inform residents of the situation and put in policies to protect human health. The results could help residents know the level of contamination of water from their boreholes and the necessary precautions to take to reduce their health impact. A treatment system can be developed in detail to their peculiar need.
Supplementary Table S9 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S9
Supplementary Table S8 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S8
Supplementary Table S6 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Supplementary Table S6
Figure S6 from KHSRP Stabilizes m6A-Modified Transcripts to Activate FAK Signaling and Promote Pancreatic Ductal Adenocarcinoma Progression
Authors: Xu Zilan , Zhou Yifan , Liu Shaoqiu , Zhao Hongzhe , Chen Ziming , Li Rui , Li Mei , Huang Xudong , Deng Shuang , Zeng Lingxing , Zhao Sihan , Zhang Shaoping , He Xiaowei , Liu Ji , Xue Chunling , Bai Ruihong , Zhuang Lisha , Zhou Quanbo , Chen Rufu , Lin Dongxin , Zheng Jian , Zhang Jialiang
Published: November 2024

Figure S6 and it's legend
Figure S3 from Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
Authors: Becker Jeffrey H. , Metropulos Anastasia E. , Spaulding Christina , Marinelarena Alejandra M. , Shields Mario A. , Principe Daniel R. , Pham Thao D. , Munshi Hidayatullah G.
Published: November 2024

Venetoclax has minimal effects on the efficacy of MRTX1133 on 2D ‘high’ confluent 2D tissue culture plastic.
Figure S1 from Targeting BCL2 with Venetoclax Enhances the Efficacy of the KRASG12D Inhibitor MRTX1133 in Pancreatic Cancer
Authors: Becker Jeffrey H. , Metropulos Anastasia E. , Spaulding Christina , Marinelarena Alejandra M. , Shields Mario A. , Principe Daniel R. , Pham Thao D. , Munshi Hidayatullah G.
Published: November 2024

PDAC cells in ‘high’ confluent collagen cultures exhibit reduced proliferation.
Figure S1 from Molecular Characterization and Classification of HER2-Positive Breast Cancer Inform Tailored Therapeutic Strategies
Authors: Li Yu-Wei , Dai Lei-Jie , Wu Xiang-Rong , Zhao Shen , Xu Yu-Zheng , Jin Xi , Xiao Yi , Wang Ying , Lin Cai-Jin , Zhou Yi-Fan , Fu Tong , Yang Wen-Tao , Li Ming , Lv Hong , Chen Siyuan , Grigoriadis Anita , Jiang Yi-Zhou , Ma Ding , Shao Zhi-Ming
Published: November 2024

Figure S1
Figure S12 from FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis
Authors: Liu Xiaoli , Chen Bonan , Xie Fuda , Wong Kit Yee , Cheung Alvin H.K. , Zhang Jinglin , Wu Qian , Fang Canbin , Hu Jintao , Wang Shouyu , Xu Dazhi , Chen Jianwu , Wang Yuzhi , Wong Chi Chun , Chen Huarong , Wu William K.K. , Yu Jun , Chan Michael W.Y. , Tsang Chi Man , Lo Kwok Wai , Tse Gary M.K. , To Ka-Fai , Kang Wei
Published: November 2024

Supplementary Figure S12
Supplementary Data Figure S2 from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
Authors: Rodarte Kathia E. , Nir Heyman Shaked , Guo Lei , Flores Lydia , Savage Trisha K. , Villarreal Juan , Deng Su , Xu Lin , Shah Rajal B. , Oliver Trudy G. , Johnson Jane E.
Published: November 2024

IHC characterization of RPM tumors and histopathology assessment of allografts.
Gels and unmerged images from Neuroendocrine Differentiation in Prostate Cancer Requires ASCL1
Authors: Rodarte Kathia E. , Nir Heyman Shaked , Guo Lei , Flores Lydia , Savage Trisha K. , Villarreal Juan , Deng Su , Xu Lin , Shah Rajal B. , Oliver Trudy G. , Johnson Jane E.
Published: November 2024

PCR genotyping gels and unmerged images from immunofluorescence.
Supplementary Table 1 from TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas
Authors: Gonzalez-Buendia Edgar , Zhao Junfei , Wang Lu , Mukherjee Subhas , Zhang Daniel , Arrieta Víctor A. , Feldstein Eric , Kane J. Robert , Kang Seong Jae , Lee-Chang Catalina , Mahajan Aayushi , Chen Li , Realubit Ronald , Karan Charles , Magnuson Lisa , Horbinski Craig , Marshall Stacy A. , Sarkaria Jann N. , Mohyeldin Ahmed , Nakano Ichiro , Bansal Mukesh , James Charles D. , Brat Daniel J. , Ahmed Atique , Canoll Peter , Rabadan Raul , Shilatifard Ali , Sonabend Adam M.
Published: November 2024

Transcriptional targets of TOP2B based on gene lists from MsigDB
Supplementary Figure 2 from Kinobead Profiling Reveals Reprogramming of BCR Signaling in Response to Therapy within Primary CLL Cells
Authors: Linley Adam J. , Karydis Laura I. , Mondru Anil K. , D'Avola Annalisa , Al Shmrany Humood , Cicconi Silvia , Griffin Rebecca , Forconi Francesco , Pettitt Andrew R. , Kalakonda Nagesh , Rawstron Andrew C. , Hillmen Peter , Steele Andrew J. , MacEwan David J. , Packham Graham , Prior Ian A. , Slupsky Joseph R.
Published: November 2024

Supplementary Figure 2: A; Venn diagram showing overlap of larger kinobead signatures derived from MEC-1 and primary CLL cell experiments. B; Graph comparing kinases identified at either mRNA level, protein (by kinobead isolation) or both in our patient cohort. C; Venn diagram to compare overlap of the refined 32 kinase signature gained from primary CLL experiments in relation to the malignant lymphoid cell lines MEC-1, MAVER-1 and JeKo-1. D; Correlation graphs for 2 representative CLL patients, comparing intensities gained for our kinome signature for 2 biological repeats for baseline (Control F(ab')2) cells and in response to anti-IgM treatment. E; Heatmaps showing kinome fingerprints for CLL patients stratified according to IGHV mutation status, Binet staging or karyotype status. F; Graphs illustrating relative change in isolation of SYK and BTK in primary CLL cells from patients stratified according to in vitro iCa2+ flux response as being Non-Signaler (NS; iCa2<5%), or Signaler (S; iCa2+>5%).
YAP Regulates HER3 Signaling–Driven Adaptive Resistance to RET Inhibitors in RET-Aberrant Cancers
Authors: Katayama Yuki , Yamada Tadaaki , Tanimura Keiko , Kawachi Hayato , Ishida Masaki , Matsui Yohei , Hirai Soichi , Nakamura Ryota , Morimoto Kenji , Furuya Naoki , Arai Sachiko , Goto Yasuhiro , Sakata Yoshihiko , Nishino Kazumi , Tsuchiya Michiko , Tamiya Akihiro , Saito Go , Muto Satoshi , Takeda Takayuki , Date Koji , Fujisaka Yasuhito , Watanabe Satoshi , Fujimoto Daichi , Uehara Hisanori , Horinaka Mano , Sakai Toshiyuki , Yano Seiji , Tokuda Shinsaku , Takayama Koichi
Published: November 2024

Purpose:

Rearranged during transfection (RET) aberrations represent a targetable oncogene in several tumor types, with RET inhibitors displaying marked efficacy. However, some patients with RET-aberrant cancer are insensitive to RET tyrosine kinase inhibitors (TKI). Recently, drug-tolerant mechanisms have attracted attention as targets for initial therapies to overcome drug resistance. The underlying mechanisms of drug-tolerant cell emergence treated with RET-TKIs derived from RET-aberrant cancer cells remain unknown. This study investigated the role of YAP-mediated HER3 signaling in the underlying mechanisms of adaptive resistance to RET-TKIs in RET-aberrant cancer cells.

Experimental Design:

Four RET-aberrant cancer cell lines were used to assess sensitivity to the RET-TKIs selpercatinib and pralsetinib and to elucidate the molecular mechanisms underlying adaptive resistance using RNA sequencing, phospho–receptor tyrosine kinase antibody arrays, chromatin immunoprecipitation assay, and luciferase reporter assays. Clinical specimens from patients with RET fusion–positive lung cancer were analyzed for pretreatment YAP expression and correlated with treatment outcomes.

Results:

In high YAP-expressing RET-aberrant cancer cells, YAP-mediated HER3 signaling activation maintained cell survival and induced the emergence of cells tolerant to the RET-TKIs selpercatinib and pralsetinib. The pan-ErBB inhibitor afatinib and YAP/tea domain inhibitors verteporfin and K-975 sensitized YAP-expressing RET-aberrant cancer cells to the RET-TKIs selpercatinib and pralsetinib. Pretreatment YAP expression in clinical specimens obtained from patients with RET fusion–positive lung cancer was associated with poor RET-TKI treatment outcomes.

Conclusions:

The YAP–HER3 axis is crucial for the survival and adaptive resistance of high YAP-expressing RET-aberrant cancer cells treated with RET-TKIs. Combining YAP/HER3 inhibition with RET-TKIs represents a highly potent strategy for initial treatment.
Supp. Fig. 3 from Dual A2A/A2B Adenosine Receptor Antagonist M1069 Counteracts Immunosuppressive Mechanisms of Adenosine and Reduces Tumor Growth In Vivo
Authors: Schiemann Kai , Belousova Natalya , Matevossian Armine , Nallaparaju Kalyan C. , Kradjian Giorgio , Pandya Meghana , Chen Zhouxiang , Aral Esengul , Krauel Eva-Maria , Petrova Elissaveta , Boesler Carsten , Kitzing Thomas , Lecomte Marc , Wagner Christian , Blayo Anne Laure , Schann Stephan , Huck Bayard , Moisan Jacques , Zaynagetdinov Rinat
Published: November 2024

Supplementary Figure 3
Supplementary Figure S4 from Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
Authors: Xiang Shengyan , Craig Kendall C. , Luo Xingju , Welch Darcy L. , Ferreira Renan B. , Lawrence Harshani R. , Lawrence Nicholas J. , Reed Damon R. , Alexandrow Mark G.
Published: November 2024

Supplementary Figure S4
Supplementary Figure S1 from Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
Authors: Xiang Shengyan , Craig Kendall C. , Luo Xingju , Welch Darcy L. , Ferreira Renan B. , Lawrence Harshani R. , Lawrence Nicholas J. , Reed Damon R. , Alexandrow Mark G.
Published: November 2024

Supplementary Figure S1
Supplemental Figure 2 from SC134-TCB Targeting Fucosyl-GM1, a T Cell–Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models
Authors: Dave Foram , Vaghela Poonam , Heath Bryony , Dunster Zuzana , Dubinina Elena , Thakker Dhruma , Mann Katie , Chadwick Joe , Cane Gaëlle , Kaira Bubacarr G. , Mohammed Omar J. , Choudhury Ruhul , Paston Samantha , Parsons Tina , Vankemmelbeke Mireille , Durrant Lindy
Published: November 2024

Target-dependent SCLC binding
Figure S1 from Novel Inhibition of Central Carbon Metabolism Pathways by Rac and CDC42 inhibitor MBQ167 and Paclitaxel
Authors: Cruz-Collazo Ailed M. , Katsara Olga , Grafals-Ruiz Nilmary , Colon Gonzalez Jessica , Dorta-Estremera Stephanie , Carlo Victor P. , Chorna Nataliya , Schneider Robert J. , Dharmawardhane Suranganie
Published: November 2024

Supplementary Figure 1
Figure S6 from YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma
Authors: Furutake Yoko , Yamaguchi Ken , Yamanoi Koji , Kitamura Sachiko , Takamatsu Shiro , Taki Mana , Ukita Masayo , Hosoe Yuko , Murakami Ryusuke , Abiko Kaoru , Horie Akihito , Hamanishi Junzo , Baba Tsukasa , Matsumura Noriomi , Mandai Masaki
Published: November 2024

Supplementary Figure 6
Supplementary Table S1 from NAD+ Metabolic Enzyme Inhibitor as Radiosensitizer for Malignant Meningioma and its Modulation of P53 Expression
Authors: Lv Yifan , Deng Yuxuan , Feng Jie , Liu Jinqiu , Yang Mingxu , Pu Zhuonan , Zhang Shaodong , Wu Zhen , Ji Nan , Park Deric M. , Hao Huyu
Published: November 2024

Supplementary Table S1
Supplementary Figure S3 from NAD+ Metabolic Enzyme Inhibitor as Radiosensitizer for Malignant Meningioma and its Modulation of P53 Expression
Authors: Lv Yifan , Deng Yuxuan , Feng Jie , Liu Jinqiu , Yang Mingxu , Pu Zhuonan , Zhang Shaodong , Wu Zhen , Ji Nan , Park Deric M. , Hao Huyu
Published: November 2024

Supplementary Figure S3
Figure S6 from Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas
Authors: Charalambous Antonia , Mpekris Fotios , Panagi Myrofora , Voutouri Chrysovalantis , Michael Christina , Gabizon Alberto A. , Stylianopoulos Triantafyllos
Published: November 2024

Figure S6
Figure S5 from Tumor Microenvironment Reprogramming Improves Nanomedicine-Based Chemo-Immunotherapy in Sarcomas
Authors: Charalambous Antonia , Mpekris Fotios , Panagi Myrofora , Voutouri Chrysovalantis , Michael Christina , Gabizon Alberto A. , Stylianopoulos Triantafyllos
Published: November 2024

Figure S5
Supplementary Table 1 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

Individual and mean serum T-MMAU toxicokinetic parameters following three i.v. bolus doses of T-mavg-MMAU DAR4 in male cynomolgus monkeys.
Supplementary Figure 3 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

ADC in vitro activity against cancer cell lines with different HER2 expression levels.
Supplementary Figure 2 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

Characterization of DAR4 ADCs.
Fig. S4 from Inhibition of SUMOylation Induces Adaptive Antitumor Immunity against Pancreatic Cancer through Multiple Effects on the Tumor Microenvironment
Authors: Erdem Suna , Lee Hyojae James , Shankara Narayanan Jayanth Surya Narayanan , Tharuka Mohottige Don Neranjan , De la Torre Jorge , Ren Tianchen , Kuang Yixuan , Abeywardana Tharindumala , Li Kevin , Berger Allison J. , Lowy Andrew M. , White Rebekah R. , Chen Yuan
Published: November 2024

Fig. S4
Supplementary Figure 1 from Trastuzumab-MMAU Antibody-Auristatin Conjugates: Valine-Glucoserine Linker with Stabilized Maleimide Conjugation Improves In Vivo Efficacy and Tolerability
Authors: Goldberg Shalom D. , Satomaa Tero , Aina Olulanu , Aitio Olli , Burke Krista , Dudkin Vadim , Geist Brian , Irrechukwu Onyi , Hänninen Anna-Liisa , Heiskanen Annamari , Helin Jari , Hiltunen Jukka O. , Kinyamu-Akunda Jacqueline , Klein Donna M. , Kohli Neeraj , Kotiranta Titta , Lähteenmäki Tuula , Niemelä Ritva , Pitkänen Virve , Pynnönen Henna , Rittase William , Wiley Kristen , Zhou Junguo , Saarinen Juhani
Published: November 2024

Characterization of T-mavg-MMAU DAR8.
Data from YAP1 Suppression by ZDHHC7 Is Associated with Ferroptosis Resistance and Poor Prognosis in Ovarian Clear Cell Carcinoma
Authors: Furutake Yoko , Yamaguchi Ken , Yamanoi Koji , Kitamura Sachiko , Takamatsu Shiro , Taki Mana , Ukita Masayo , Hosoe Yuko , Murakami Ryusuke , Abiko Kaoru , Horie Akihito , Hamanishi Junzo , Baba Tsukasa , Matsumura Noriomi , Mandai Masaki
Published: November 2024

Abstract
Ovarian clear cell carcinoma (OCCC), which has unique clinical characteristics, arises from benign endometriotic cysts, forming an oxidative stress environment because of excess iron accumulation, and exhibits poor prognosis, particularly in advanced stages owing to resistance to conventional therapeutics. Ferroptosis is an iron-dependent form of programmed cell death induced by lipid peroxidation and controlled by Hippo signaling. We hypothesized that overcoming ferroptosis resistance is an attractive strategy because OCCC acquires oxidative stress resistance during its development and exhibits chemoresistant features indicative of ferroptosis resistance. This study aimed to determine whether OCCC is resistant to ferroptosis and clarify the mechanism underlying resistance. Unlike ovarian high-grade serous carcinoma cells, OCCC cells were exposed to oxidative stress. However, OCCC cells remained unaffected by lipid peroxidation. Cell viability assays revealed that OCCC cells exhibited resistance to the ferroptosis inducer erastin. Moreover, Samroc analysis showed that the Hippo signaling pathway was enriched in OCCC cell lines and clinical samples. Furthermore, patients with low expression of nuclear yes-associated protein 1 (YAP1) exhibited a significantly poor prognosis of OCCC. Moreover, YAP1 activation enhanced ferroptosis in OCCC cell lines. Furthermore, suppression of zinc finger DHHC-type palmitoyltransferase 7 (ZDHHC7) enhanced ferroptosis by activating YAP1 in OCCC cell lines. Mouse xenograft models demonstrated that ZDHHC7 inhibition suppressed tumor growth via YAP1 activation by erastin treatment. In conclusion, YAP1 activation regulated by ZDHHC7 enhanced ferroptosis in OCCC. Thus, overcoming ferroptosis resistance is a potential therapeutic strategy for OCCC.
Supplementary Table S3 from Viewing Native American Cervical Cancer Disparities through the Lens of the Vaginal Microbiome: A Pilot Study
Authors: Łaniewski Paweł , Joe Tawnjerae R. , Jimenez Nicole R. , Eddie Tristen L. , Bordeaux Skyler J. , Quiroz Verity , Peace Donna J. , Cui Haiyan , Roe Denise J. , Caporaso J. Gregory , Lee Naomi R. , Herbst-Kralovetz Melissa M.
Published: November 2024

Supplementary Table S3: Differences in global health and perceived stress measurements between participants with Lactobacillus-dominant microbiota and non-Lactobacillus-dominant microbiota.
Data from Viewing Native American Cervical Cancer Disparities through the Lens of the Vaginal Microbiome: A Pilot Study
Authors: Łaniewski Paweł , Joe Tawnjerae R. , Jimenez Nicole R. , Eddie Tristen L. , Bordeaux Skyler J. , Quiroz Verity , Peace Donna J. , Cui Haiyan , Roe Denise J. , Caporaso J. Gregory , Lee Naomi R. , Herbst-Kralovetz Melissa M.
Published: November 2024

Abstract
Vaginal dysbiosis is implicated in persistent human papillomavirus (HPV) infection and cervical cancer. Yet, there is a paucity of data on the vaginal microbiome in Native American communities. Here, we aimed to elucidate the relationships between microbiome, HPV, sociodemographic, and behavioral risk factors to better understand an increased cervical cancer risk in Native American women. In this pilot study, we recruited 31 participants (16 Native American and 15 non-Native women) in Northern Arizona and examined vaginal microbiota composition, HPV status, and immune mediators. We also assessed individuals’ sociodemographic information and physical, mental, sexual, and reproductive health. Overall, microbiota profiles were dominated by common Lactobacillus species (associated with vaginal health) or a mixture of bacterial vaginosis–associated bacteria. Only 44% of Native women exhibited Lactobacillus dominance, compared with 58% of non-Native women. Women with vaginal dysbiosis also had elevated vaginal pH and were more frequently infected with high-risk HPV. Furthermore, we observed associations of multiple people in a household, lower level of education, and high parity with vaginal dysbiosis and abundance of specific bacterial species. Finally, women with dysbiotic microbiota presented with elevated vaginal levels of proinflammatory cytokines. Altogether, these findings indicate an interplay between HPV, vaginal microbiota, and host defense, which may play a role in the cervical cancer disparity among Native American women. Future longitudinal studies are needed to determine the mechanistic role of vaginal microbiota in HPV persistence in the context of social determinants of health toward the long-term goal of reducing health disparities between non-Hispanic White and Native American populations.

Prevention Relevance: Cervical cancer disproportionally affects Native American women. Sociodemographic and behavioral factors might contribute to this disparity via alteration of vaginal microbiota. Here, we show the association between these factors and vaginal dysbiosis and immune activation, which can be implicated in high-risk HPV infection among Native American and other racial/ethnic populations.
Table S3 from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Table S3
Table S1 from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Table S1
Figure S5 from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Supplementary Fig S5. In vitro co-culture experiments of TAM and CD8+ T cells and the effect of CX3CR1 overexpression on BMDMs
Figure S4 from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Supplementary Figure S4. The effect of different immunotherapy combinations on tumor infiltrating NK/NKT cells
Figure S2 from Blocking CX3CR1+ Tumor-Associated Macrophages Enhances the Efficacy of Anti-PD1 Therapy in Hepatocellular Carcinoma
Authors: Xiang Xiaonan , Wang Kai , Zhang Hui , Mou Haibo , Shi Zhixiong , Tao Yaoye , Song Hongliang , Lian Zhengxing , Wang Shuai , Lu Di , Wei Xuyong , Xie Haiyang , Zheng Shusen , Wang Jianguo , Xu Xiao
Published: November 2024

Supplementary Figure S2. H22 orthotopic HCC immunotherapy model
Supplementary Table 3 from Organ-Specific Immune Setpoints Underlie Divergent Immune Profiles across Metastatic Sites in Breast Cancer
Authors: Egelston Colt A. , Guo Weihua , Simons Diana L. , Ye Jian , Avalos Christian , Solomon Shawn T. , Nwangwu Mary , Nelson Michael S. , Tan Jiayi , Bacon Eliza R. , Ihle Kena , Schmolze Daniel , Tumyan Lusine , Waisman James R. , Lee Peter P.
Published: November 2024

Multiplex immunofluorescence antibodies
Supplementary Figure 2 from Organ-Specific Immune Setpoints Underlie Divergent Immune Profiles across Metastatic Sites in Breast Cancer
Authors: Egelston Colt A. , Guo Weihua , Simons Diana L. , Ye Jian , Avalos Christian , Solomon Shawn T. , Nwangwu Mary , Nelson Michael S. , Tan Jiayi , Bacon Eliza R. , Ihle Kena , Schmolze Daniel , Tumyan Lusine , Waisman James R. , Lee Peter P.
Published: November 2024

Flow cytometry gating strategies continued. Shown for Innate cell panel (A) and B cell panel (B).
Supplementary Table S5 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Table S5 Clinicopathological characteristics of patients used for spatial transcriptome study.
Supplementary Table S3 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Table S3 Comparative p-values for PFS rate and DFS rate in high infiltration group and low-infiltration group, stratified using different cellular characteristics in TCGA.
Table S9 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Table S9. H&E imaging file guide. A spreadsheet mapping the positions in TMA1B and TMA2B to the unique TMA IDs.
Supplementary Fig S7 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Figure S7
Table S6 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Table S6. Multivariate Cox regression result. Full multivariate Cox regression results for OS and PFS, using the top 5 features from univariate analyses.
Table S3 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Table S3. Noise filtering parameters for image data. Configuration parameters for noise filtering of multiplexed images.
Supplementary Fig S16 from CD36+ Proinflammatory Macrophages Interact with ZCCHC12+ Tumor Cells in Papillary Thyroid Cancer Promoting Tumor Progression and Recurrence
Authors: Zhang Xin , Guo Limei , Tian Wenyu , Yang Ying , Yin Yue , Qiu Yaruo , Wang Weixuan , Li Yang , Zhang Guangze , Zhao Xuyang , Wang Guangxi , Lin Zhiqiang , Yang Meng , Zhao Wei , Lu Dan
Published: November 2024

Supplementary Figure S16
Figure S21 from The Spatial Structure of the Tumor Immune Microenvironment Can Explain and Predict Patient Response in High-Grade Serous Carcinoma
Authors: Van Kleunen Lucy B. , Ahmadian Mansooreh , Post Miriam D. , Wolsky Rebecca J. , Rickert Christian , Jordan Kimberly R. , Hu Junxiao , Richer Jennifer K. , Brubaker Lindsay W. , Marjon Nicole , Behbakht Kian , Sikora Matthew J. , Bitler Benjamin G. , Clauset Aaron
Published: November 2024

Fig S21. Random forest feature importance results split by feature type - OS. Feature importance results for overall survival show in Figure 7A, split by feature type and split by subtype for spatial network features.