bluuebunny/crossref_metadata_2025 huggingface dataset:
Freiheit, Kontrolle und Verantwortlichkeit in der Gesellschaft
Authors: Albrecht Stephan
Published: July 2023

Die Verantwortung der Wissenschaften ist Ausgangspunkt intensiver Diskussionen. Aber wer trägt eine wie geartete Verantwortung für was? Das vorliegende Werk basiert auf langjähriger Forschungsarbeit zu den Entwicklungen in der modernen Biotechnologie. Die gründliche Analyse zeigt: Verantwortung tragen meistens die anderen. Politische, rechtliche, administrative und innerwissenschaftliche Kommunikations- und Handlungsstrukturen verhindern oder verdünnen Verantwortung bis zur Unauffindbarkeit. Stephan Albrecht weist anhand zahlreicher Beispiele aus Medizin, Landwirtschaft, Pharmazie und Umwelttechnik nach, dass der biotechnologische Fortschritt nicht evolutionär, sondern politisch gestaltet, menschengemacht ist. Ein grundlegender Fehler in diesem Fortschritt ist indessen, dass dieser nicht angemessen öffentlich, als Res publica, verstanden und verhandelt wird. Der Autor schlägt in demokratischer Perspektive eine institutionelle Ausprägung der Wahrnehmung von Verantwortung in den und für die Wissenschaften vor, die sich an den spezifischen Herausforderungen technologischer Innovationen orientiert und zugleich auf den besten Praktiken politischer und bürgerschaftlicher Willensbildung aufbaut.
FORMAÇÃO PEDAGÓGICA EM APRENDIZAGEM DIALÓGICA: CONTRIBUIÇÕES PARA A FORMAÇÃO DE PROFESSORES(AS) EM TEMPOS DE DISTANCIAMENTO SOCIAL
Authors: SILVA VIVIAN MASSULLO , BRAGA FABIANA MARINI , CARVALHO AMANDA DE , MOREIRA RAQUEL
Published: July 2023

RESUMO Este artigo apresenta resultados de pesquisa desenvolvida a partir do curso de formação em Aprendizagem Dialógica, ofertado remotamente durante o período de distanciamento social ocasionado pela pandemia da COVID-19, com recorte específico sobre a formação de professores(as). A pesquisa foi realizada por meio de formulário eletrônico preenchido pelos(as) cursistas, relatos e grupo focal comunicativo, realizados após o término do curso. O objetivo foi compreender o impacto do curso de formação em Aprendizagem Dialógica no conhecimento teórico e prático de professores(as) e sua relação com o enfrentamento do isolamento social. Pautados no referencial da Metodologia Comunicativa, as respostas obtidas foram sistematizadas em elementos transformadores e excludentes em relação às contribuições do curso para a formação de professores(as) e para o enfrentamento da pandemia. Como resultados, destacam-se a dimensão instrumental, a necessidade da formação de professores(as) aliada às evidências científicas e a criação de sentido como elementos transformadores. Os dados também revelaram que a falta de diálogo e a estrutura verticalizada dos sistemas de ensino são elementos que distanciam as práticas pedagógicas dos(as) professores(as) de melhores resultados educacionais. Os elementos apontados como transformadores deram suporte para que os(as) participantes buscassem respostas para os problemas enfrentados em seus cotidianos profissionais e pessoais. Esperamos que este artigo contribua com o campo da formação de professores(as), promovendo reflexão sobre a necessidade de alinhar essa formação com os estudos produzidos pela comunidade científica internacional.
UM PANORAMA DAS AÇÕES EXTENSIONISTAS DESENVOLVIDAS EM CURSOS SUPERIORES DE COMPUTAÇÃO
Authors: MIRANDA FREDERICO SEVERO , AMARAL MARÍLIA ABRAHÃO
Published: July 2023

RESUMO: O tripé das universidades brasileiras é composto por ensino, pesquisa e extensão. A partir das ações de extensão, é possível articular o conhecimento científico em conjunto com as necessidades da sociedade e, dessa forma, respaldadas por valores democráticos e igualdade de direitos, tais ações são capazes de promover o desenvolvimento social local. Entendendo a importância social oportunizada pelas ações de extensão, propõe-se a seguinte pergunta: como estão sendo realizadas as ações de extensão nas universidades? Neste contexto, o método utilizado para responder à pergunta em questão foi a execução de uma revisão bibliográfica sistemática que considerou as publicações dos últimos dez anos presentes nas seguintes bases digitais: ACM, CEIE, IEEE, RBIE, Renote, ScienceDirect, SBIE e WIE. Foram utilizadas 25 palavras-chave, um critério de inclusão e seis critérios de exclusão. Após a extração dos dados e análise crítica referente aos artigos selecionados a partir de uma perspectiva freireana, foi construído um panorama sobre as ações extensionistas na área de Computação. Um dos oito itens que compõem esse panorama trouxe à luz, por exemplo, que 61,54% das ações de extensão abordam tópicos referentes ao pensamento computacional ou ao ensino de programação. Observando-se o panorama geral encontrado, foi possível concluir que as ações de extensão apresentaram, por exemplo, uma hegemonia de tópicos de estudos, foco específico em um determinado público, baixo protagonismo discente, entre outras questões.
“THE FAILURE OF NEW SCHOOL REFORM”: ATALIBA DE OLIVEIRA INTERPRETING THE PAULISTA SCHOOL RENOVATION (THE 1930s AND 1940s)
Authors: VALDEMARIN VERA TERESA , OLIVEIRA MARCUS ALDENISSON DE
Published: July 2023

ABSTRACT: Under the perspective guided by Darnton (1986), this article aims to capture the interpretations made by Ataliba Antonio de Oliveira about the new school movement. It is about a teacher from São Paulo who followed and resisted closely and from within the onslaughts and attempts at pedagogical renewal in progress in the São Paulo school system. By writing more than two hundred chronicles, interpreting among other themes the initiatives of the Escolanovistas in São Paulo, Ataliba de Oliveira pointed out the errors that characterized “the failure of new school reform”. After inventorying and analyzing these chronicles, this article intends to answer the question: How did Ataliba de Oliveira interpret the new school movement and the tentatives of inserting this pedagogical doctrine in the Paulista school apparatus between 1930 and 1940? The comparative logical structures the most of the chronicles, and through them, are revealed his most scathing criticism to the reform, the reformers, and the educational consequences of those actions. He also revealed the patterns that he intended to preserve. Taken together, the chronicles of Ataliba de Oliveira made up the interpretation that “the failure of new school reform” occurred because its apologists did not consider the data and situations of the Paulista school reality, nor the conditions faced by teachers and students in the educational task.
Psychological distress in nursing students: relationship with screen time, diet and physical activity
Authors: Ramón-Arbués Enrique , Granada-López José Manuel , Satústegui-Dordá Pedro José , Echániz-Serrano Emmanuel , Sagarra-Romero Lucía , Antón-Solanas Isabel
Published: July 2023

Objective: to determine the prevalence of anxiety and depression symptoms, as well as their association with screen time, diet and physical activity, in a cohort comprised by nursing students. Method: a descriptive and cross-sectional study conducted with a sample of 648 Nursing students. The instruments used were the Hospital Anxiety and Depression Scale, the short version of the International Physical Activity Questionnaire and the Spanish Healthy Eating Index (Índice de Alimentación Saludable Español, IASE). Different multiple linear regression models were performed to analyze the association between anxiety/depression symptoms and screen time, diet and physical activity. Results: the prevalence values for anxiety and depression symptoms were 24.1% and 3.7%, respectively. Prolonged screen times (>6 hours a day), low levels of physical activity and inadequate diet were independently and significantly associated with deeper psychological symptoms. Conclusion: Nursing students’ mental health might benefit from the implementation of initiatives promoting healthy lifestyles.
Beyond science denialism: disinformation during the Covid-19 pandemic
Authors: Miskolci Richard
Published: July 2023

Abstract An analysis of an archive formed by editorials from two of the most important Brazilian newspapers during the first two years of the Covid-19 pandemic identified the predominance of a framing that attributed decisions of the Bolsonaro government to a denial of science. Based on historical and sociological sources, this paper discusses what this normative framing about science and health ignored, especially how the extreme-right adapted use of the paradigm of disinformation created by the tobacco industry to the new mediatic ecosystem. The paper concludes that the journalistic framing of science denialism emphasized criticisms that accused the state of incompetence, giving less visibility to the role of the federal Unified Healthcare System during the health emergency.
Percorrendo labirintos: identidades fragmentadas e cultura política no divã
Authors: Vasconcelos Francisco Thiago Rocha
Published: July 2023

Resumo A presente resenha aborda o livro da historiadora e psicanalista francesa Elisabeth Roudinesco, uma polêmica (e necessária) reconstrução crítica de temas tabus do pensamento e da ação política vinculados aos estudos pós-coloniais, decoloniais, subalternos e aos movimentos negro, feminista radical e queer. A autora se concentra no que chama de “derivas identitárias”, consolidadas nos estudos e nas produções acadêmicas sobre gênero, raça, “pós-colonialidades” e interseccionalidade, em paralelo ao “identitarismo” de direita.
Sugarcane (Saccharum officinarum) bagasse as a source of fiber and fat replacer in ice creams: chemical, microbiological, and sensory evaluation
Authors: Moreno Luis Zuniga , Damian Fernando , Landines Edgar , El-Salous Ahmed
Published: July 2023

Abstract Agricultural by-products are relevant sources of valuable bioactive compounds, such as fiber, which its regular ingestion is associated with health benefits. This study evaluated the chemical, microbiological, and sensory properties of ice cream using the sugarcane bagasse as a partial fat replacer and fiber-enrichment component. Three ice cream formulations containing 15% (T1); 20% (T2) and 25% (T3) of sieved dried bagasse fiber were produced and compared against a control ice cream (C) without including the by-product. Fat content reduction was 53.40%, 78.88% and 81.99%, respectively; and, the total dietary fiber values increased 14.2%, 19.0% and 24.3%, respectively. Microbiological parameters of all ice cream formulations complied with the requirements established in the Ecuadorian standard for ice creams - NTE INEN 706:2013 and the limits for the mold and yeast count included in the Argentine Food Code. Compared with the control sample (C), formulation T1 did not show a significant statistical difference (p > 0.05) for four out of the five sensory parameters assessed (appearance, texture, flavor, and general acceptance, except taste) using a 9-point structured hedonic scale. The bagasse fiber resulted in a promising food ingredient suitable for reducing fat content and increasing fiber value.
CLINICAL PHOTOGRAPHIC AND RADIOLOGICAL CORRELATION IN PATIENTS WITH SCOLIOSIS
Authors: Gonçalves Thales Henrique Garcia , Defino Helton Luiz Aparecido
Published: July 2023

ABSTRACT Objective: The study correlates angular radiographic measurements and measurements from photographs of the trunk of patients with adolescent idiopathic scoliosis. Methods: a cross-sectional study of 10 patients with adolescent idiopathic scoliosis and indication for surgical treatment in follow-up in the spine sector of HCRFMRP-USP. They were evaluated through measurements taken from clinical photographs of the patient’s torso and angles on panoramic radiographs of the spine. Results: only the correlation between the axilla angle (AHA) and the proximal thoracic curve and main thoracic curve was observed in the sample studied. No correlation was observed between the other compared variables. The study was carried out in a sample with a small number of patients, whose objective was to carry out a pilot study to explore this topic. Conclusion: the analysis of deformities should consider the aesthetic aspect and radiographic evaluation; however, in this study, no statistical correlation was observed between these parameters. Level of Evidence IV; Case Series Study.
Onomatopoetic words – between speech and language
Authors: Sharonov Igor
Published: July 2023

The article is devoted to the class of onomatopoetic interjections in Russian (e.g. miau-miau, bats, chpock and so on). Their primary function is to represent sound imitations. Some of them can also function as predicates and as metatekst words. There are few classifications of Russian onomatopoetic words. In one of them these words should be classified according to the level of their conventional status, relevant to translation purposes (Vlakhov, 1980). On the one end of the conventional scale words are highly conventional, language specific and translatable (gav-gav, tik-tak). On the other end of the scale there are nonconventional words, iconically depicting the sound itself. One more classification tends to divide these words as depicting acoustic events / non-depicting acoustic events, but indicating actions and demonstrating emotional effect of suddenness (Sharonov, 2010; Kanerva, 2018). The special attention in the article is devoted to the analysis of three groups of words which have not been considered precisely by Russian linguists. One group serves to interpret musical sounds, one more group serves to interpret chats, assess somebody’s words as bullshits (bla-bla, traly-valy and so on). And the last one contains onomatopoetic euphemisms of swear words.
Determining factors of sustainability report using the institutional isomorphism theory approach
Authors: Nugrahani Tri Siwi , Kusuma Hadri , Arifin Johan , Muhammad Rifqi
Published: July 2023

One form of company participation in sustainable development is the preparation of quality reports (SR) taking into account SR content and pressure from stakeholders including the determinants of SR quality in companies listed on the IDX during 2017-2020 with an isomorphism theory approach. The sample for this study was 444 companies using the purposive method, with the criteria for companies compiling SRs during the year of observation either separately or in combination with the annual financial statements. Data analysis with multivariate regression. The results showed that environmental pressure and social pressure coercively isomorphism had an effect on SR quality, and industrial pressure had mimetic isomorphism affected SR quality, while normative pressure from the audit committee had no effect on SR quality because p > 0.05. This study proves that testing the quality of SR with a coercive, mimetic, and normative isomorphism theory approach can determine the quality of SR.
The power of sharing the case of Sederhana (SA) restaurants in Indonesia
Authors: Adnan Muhammad Akhyar
Published: July 2023

This paper aims to investigate and describe how the practice of sharing system is applied in one of Indonesia’s well-known and largest indigenous restaurant chains. The research applies a case study method. It is focused only on a single company with around two hundred branches nationwide. The data were mainly collected by deep interviews and observations. All data are analysed qualitatively. An interactive model as suggested by Miles and Huberman (1994) is adopted. The study found that this company has a very distinctive method not only for its financial matters, but also the operations in general. The operations seem to apply the mixed musharaka and mudharaba principles; although the Islamic term is hardly used, the values applied are Islamic in nature. The business model can offer widely that there is another model of business which promises the power of sharing among the participants.
Elections and Electoral Processes in Somaliland: A Fading Democracy
Authors: Abdulahi Hamdi I
Published: July 2023

After declaring its independence from Somalia in 1991, Somaliland has built a system to deliver basic services to its citizens. Despite having relatively good security, Somaliland has to date received no international recognition. With the presidential term extension made by the House of Elders (the Guurti) in October 2022, politics in Somaliland is at fever pitch. Public demonstrations, sporadic clashes, mass arrests, and hate speech add to a general sense of political disorder. Several factors have shaped the current outlook for democracy in Somaliland, including clan politics, a rent-seeking mentality, and weak institutional and legal frameworks. This study seeks to emphasise the contentious way in which elections have been held in Somaliland, and which have led to a loss of confidence in the country. The results, as witnessed in the 2017 presidential election, led to disputes, mass protests, and loss of life. Election time in Somaliland has therefore been a cause of concern for both political parties and the Somaliland Election Commission. In the battle for political leadership, the pre- and post-electoral aftermath has become conventional. But the main victim of the battle for political leadership has been the Somaliland Election Commission which is torn between contesting political parties.
Senior Drivers’ Body Movement Strategies for Getting in and Out of Cars: A Study by Vehicle Typology
Authors: Fernandes Susana C. F.
Published: July 2023

During normal ageing, physical changes take place, namely in terms of the biomechanical, musculoskeletal, and psychomotor systems, that reduce strength, flexibility, motor coordination, balance, and precision of movements. This article analyses the motion behaviour of a sample of 49 senior and pre-senior subjects during the process of entry to (ingress) and exit from (egress) new car models not experienced before, obtained over five days at the Geneva International Motor Show. The methodological process is based on visual studies using photography and video to analyse motion behaviour. This investigation identifies five entry movement strategies and three exit movement strategies in three types of vehicle groups. The movements adopted in the egress of the vehicle were more complex and difficult, in general, than those observed for ingress, requiring greater flexibility, agility/dexterity, and physical strength of subjects, involving more contact or support with vehicle parts. The main factor that influences movement strategies is essentially related to subjects’ levels of physical capacity and previous experiences. In conclusion, there are no significant changes in the subjects’ somatic movement strategies based on vehicle types.
Deflection of Null and Time-like Geodesics in Topological Defects Space-time Geometry
Authors: Ahmed Faizuddin , Kayum Abdul , CHOUDHURY MONJUR ALOM , Hassan Mahmudul
Published: July 2023

In this work, we study the deflection of photon light and/or time-like geodesics in the background of the topological defects in four-dimensional space-time geometry. These topological defects geometries are cosmic string space-time with screw dislocation, spiral dislocation, and spacelike dislocation. We derive the deflection of light-like and time-like geodesics and show the effects of cosmic string parameter, screw dislocation parameter, and spacelike dislocation parameter on them. Our derivation technique is based on the fact that the photon rays (light-like) and/or time-like geodesics is along the path parallel to the z-axis with constant radius of the cylinder.
Irreducible Ankle Fracture Dislocation Because of Tibialis Posterior and Flexor Digitorum Longus Tendon Entrapment in the Interosseous Membrane
Authors: Shon Hyun-Chul , Lim Eic-Ju , Yang Jae-Young
Published: July 2023

Case:

We describe the case of a 63-year-old man with anterior ankle dislocation and fracture confirmed by x-ray. Postreduction x-ray and computed tomography (CT) revealed Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association (AO/OTA) type 44C3 and Lauge-Hansen pronation-external rotation–type ankle fractures.

Conclusion:

This was a rare case of ankle fracture dislocation because of entrapment of the tibialis posterior and flexor digitorum longus tendons in the interosseous membrane. Tendon entrapment should be suspected in cases of high-energy injuries, Weber type C fractures, Lauge-Hansen pronation-external rotation fractures, syndesmosis widening, and irreducible fractures using manual closed reduction. Fractures and soft tissues should be evaluated by changing the CT settings.
Identifying the Change of Seepage Field in Karst Aquifer under Tunnel Engineering: Insight from FEFLOW Modeling
Authors: Zhang Yunhui , Hu Xiangbo , Luo Huan , Liu Yang , Yao Rongwen , Duo Ji , Li Xiao , Huang Xun
Published: July 2023

Water inrush is one of the most serious phenomena threatening the safety of tunnel construction. The West Qinling 1# tunnel, as the major section of the Bailong River diversion project, traverses a complicated karst area and would be faced with a water inrush disaster. Based on geological and hydrogeological conditions, the Finite element subsurface flow system software is used to simulate and predict the development of the natural seepage field and dredging construction conditions of the seepage field on the West Qinling 1# tunnel area. The prediction results show that the groundwater level will drop up to 113.9 m under dredging construction conditions, with an impact radius of up to 11.5 km. Seepage field evolution and water influx were simulated under two conditions of construction plugging construction, respectively. The prediction results show that the groundwater level in the middle part of tunnel 1# is 112.68 m depth without blocking condition with an influence range of 10.5 km. The maximum water volume per unit length of the karst cave increases to 4.32 m3/d·m. In the plugging condition, the influencing scope does not significantly reduce, but the extent of the impact is greatly weakened. The groundwater level generally dropped at 10–25 m depth and the karst cave section unit length of the maximum water volume of 0.83 m3/d·m in the rainy season. The achievements of this study would provide a vital reference for the prevention of water inrush in karst tunnel construction.
Knowledge, Attitudes and Acceptance towards COVID-19 Vaccination among Health Care Workers in Mukalla city-YEMEN: an analytical cross-sectional study
Authors: Bnqadeem Aseel , Alsabban Mohammed , Bokir Khulod , Al-Ghazali Ruqaiah , Gaber Sarah Bin Ali , Balfaqih Sumaia , Marei Fatima Bin , Al-Amodi Fatima , Atash Sumaia
Published: July 2023

Background

COVID-19 vaccination is one of the greatest public health interventions to reduce the burden of the COVID-19 pandemic. Yemen began on April 2021 to vaccinate healthcare workers for COVID-19 with the vaccine. However, the media's negative portrayal of vaccines safety and efficacy has led to concerns regarding the acceptance of the vaccine. Therefore, our study aimed to assess knowledge, attitudes and acceptance towards COVID-19 Vaccination among HCWs in Mukalla city-Yemen.

Methods

An analytical cross-sectional study was conducted using convenience sampling method in Mukalla city among healthcare workers from April 2022 to May 2022. Data were collected by a self-administered questionnaire. A Chi-square test was used to assess the association between independent variables (demographic) and dependent variables (knowledge, attitude and acceptance). Correlation between knowledge and attitude levels with rate of acceptance was assessed using Pearson correlation coefficient.

Results

449 respondents were included in the final analysis, of which 237 (52.8%) were males and 212 (47.2%) were females, with a mean age ± SD of 31.0 ± 7.6 years. The overall results regarding knowledge, attitude, and acceptance rates of the COVID-19 vaccines were 65.3% 63.7% and 68.8% (with an efficacy of 90%), respectively. Acceptance was statistically associated with participants’ job, vaccination state, whether they were dealing with suspected cases of COVID-19 and their source of COVID-19 related information (p-value < 0.05). level of acceptance was moderately correlated with attitude level (r = 0.527).

Conclusion

Healthcare workers were found to have a moderate level of knowledge and attitude toward COVID-19 vaccination. However, acceptance rate was scaling down according to vaccine efficacy. Many demographic characteristics were significantly associated with acceptance of COVID-19 vaccination.
Cascade-amplification of melanoma-targeted radio-immunotherapy via fusogenic liposomes functionalized with multivariate-gated aptamer assemblies
Authors: Luo Zhong , Xue Rui , Ren Xijiao , Wang Shuang , Ge Xinyue , Yao Xuemei , Min Junxia , Li Menghuan , Wang Fudi , Li Liqi
Published: July 2023

Radio-immunotherapy exploits the immunostimulatory features of ionizing radiation (IR) to enhance antitumor effects and offers emerging opportunities for treating invasive tumor indications such as melanoma. However, insufficient dose deposition and immunosuppressive microenvironment (TME) of solid tumors limit its efficacy. To address these challenges, a cascade-amplification strategy based on multifunctional fusogenic liposomes (Lip@AUR-ACP-aptPD-L1) was reported. The liposomes were loaded with gold-containing Auranofin (AUR) and inserted with multivariate-gated aptamer assemblies (ACP) and PD-L1 aptamers in the lipid membrane, potentiating melanoma-targeted AUR delivery while transferring ACP onto cell surface through selective membrane fusion. AUR amplified IR-induced immunogenic death of melanoma cells to release antigens and damage-associated molecular patterns such as ATP for triggering adaptive antitumor immunity. AUR-sensitized radiotherapy also upregulated MMP-2 expression that combined with released ATP to cause AND-gate activation of ACP, thus triggering the in-situ release of CpG-based immunoadjuvants for stimulating dendritic cell-mediated T cell priming. Furthermore, AUR inhibited tumor-intrinsic ERK1/2-HIF-1α-VEGF signaling to suppress infiltration of immunosuppressive cells for fostering an anti-tumorigenic TME. This study offers an approach for solid tumor treatment in the clinics.
Green synthesis of pyrazolines as anti-inflammatory, antimicrobial and antioxidant agents
Authors: Pawar Kiran Prakash , Bhosale Sachin , Dhake Avinash , Shinde Nirmala
Published: July 2023

Green methods such as microwave technique and grinding technique have been found superior over the conventional method in view of reaction time and energy requirement. Pyrazoline derivatives , 2a-i and 3a-i, were synthesized both conventional heating and by microwave irradiation, the synthesized compounds were characterized by 1H NMR, 13C NMR, IR and mass spectral analyses. They were screened for their in vitro anti-inflammatory, antimicrobial and antioxidant activities. Antimicrobial activity was performed by Agar plate method and 2d & 2e were active against Gram negative bacteria E. coli and S. aureus, 3c and 3g showed antioxidant activity (IC50=48.13 and 46.03μg/ml),3c shows respectively anti-inflammatory activity at (EC50= 11.00±1.26 µg/mL) 3c ,3d and 3e showed good anti-inflammatory activity at concentration (EC50= 11.70±0.98 µg/mL) & 11.70±0.98 µg/mL respectively.
Simulation of Triple-bands LSPR based on Exposed-core MOF with Multilayered Nanoshell: Application in Multiplex RI Sensing
Authors: Yang Guan , Hu Chengyuan , Chen Meize , Yang Xianchao , Liu Yuhuai , Sun Xiaohong , Yao Jianquan
Published: July 2023

A localized surface plasmon resonance (LSPR) refractive index (RI) sensor based on exposed-core micro-structured optical fiber (EC-MOF) with a multilayered nanoshell (MNS) is designed. The triple-bands LSPR provided by the MNS, which consists of a gold core and a silver shell that separated by a dielectric layer, can realize the detection of three different targets simultaneously for the first time to our best knowledge. The novel characteristics of intense and distinct resonance peak at shorter wavelength is different from the higher order SPR modes, and the physical mechanism of MNS is illustrated by plasmon hybridization theory. The RI sensing ability is investigated at 1.33-1.42 in both wavelength and amplitude interrogations with sensitivities of 2082 nm/RIU and 202 RIU-1. Peak 1 exhibits ultrasharp LSPR with full width half maximum (FWHM) only 6 nm, leading to figure of merit (FOM) of 347/RIU, about 6-356 times higher than other similar works. The influences of MNS structure, number, position and length in EC-MOF are all analyzed in detail. Results indicate that the sensing characteristics can be optimized by adjusting the geometrical dimensions of MNS and the sensor exhibits relative strong tolerance, which show great potential for multiplex biosensing used in harsh environment.
Genetic differences among populations of Gynura procumbens (Lour.) Merr.
Authors: Yu Jiangfan , Tan Xinjian , Huang Dunyuan , Zhong Qiuping , Gu Ping , Zhou Youcheng , Cao Linqing , Wang Liyun , Wan Xirui , Chen Chuansong , Yuan Yaqi , Guo Hongyan , Yan Chao , Wang Jinfeng , Ge Xiaoning
Published: July 2023

Twenty-four populations of Gynura procumbensfrom different geographical regions were studied to determine the genetic differences using ITS and trnL-trnF sequences. The ITS sequence had an aligned length of 718 bp and a G+C content of 49.8%, with 5 variable sites and 3 parsimonious informative sites. The trnL-trnF sequence had an aligned length of 835 bp and a G+C content of 35.0%, with 6 variable sites and 3 parsimonious informative sites. The phylogenetic tree based on trnL-trnFsequences showed that all populations of Gynura procumbens clustered into one branch, indicating that this sequence has strong identifying abilities in genetic difference studies. Furthermore, the phylogenetic analysis using both ITS and trnL-trnF sequences showed similar results. Populations collected from Taiwan and Indonesia were grouped into one clade, while those collected from Guizhou, Guangxi, Fujian, and Guangdong shared a close relationship, corresponding to their geographical distribution pattern.
Industrial solid waste based layered double hydroxide composite with enhanced adsorption affinity to Congo red, Acid red, and Reactive red
Authors: Zhang Siqian , Lee Jaewon , Li Bin , Zhang Tianyang , Baeck Sung-Hyeon , Shim Sang Eun
Published: July 2023

The synthesis of hierarchically porous materials from industrial solid waste as catalysts or adsorbents has attracted much attention in environmental pollution control. The present work highlights the synthesis of a series of MgFeAl layered double hydroxide (LDH) with different ratios of Mg/(Fe + Al) from red mud and ferronickel slag under different pH to decolorize three red dye solutions, namely, Congo red (CR), acid red (AR), and reactive red (RR). The maximum adsorption capacity (386.1 mg.g–1) for CR was obtained by the MgFeAl-LDH sample with Mg/(Fe + Al) mole ratio of 2 synthesized under pH 10. The optimized synthesis parameters led to a high surface area and large pore volume of MgFeAl-LDH, thereby enhancing the mass transfer of adsorbate to the active sites of the adsorbent. Further, the MgFeAl-LDH sample was also efficient in removing AR (120.9 mg.g–1) and RR (114 mg.g–1). Moreover, the adsorption kinetics and isotherms of MgFeAl-LDH fitted well with the pseudo-second-order and Langmuir models, respectively. The MgFeAl-LDH system developed a valuable approach to utilize industrial waste for dye removal.
Heat stress and feeding effects on the mucosa-associated and digesta microbiome and their relationship to plasma and digesta fluid metabolites in the jejunum of dairy cows
Authors: Koch Franziska , Reyer Henry , Görs Solvig , Hansen Christiane , Wimmers Klaus , Björn Kuhla
Published: July 2023

The intestinal microbiota plays a pivotal role in digestive processes and maintains gut health and intestinal homeostasis. These functions may be compromised by increased environmental heat which in turn reduces feed intake and gut integrity, while activating the intestinal immune system. However, it is not known whether high ambient temperatures, causing heat stress (HS) to dairy cows, disturb the eubiosis of the microbial community and if so, to which extent the reduction in feed intake and the impairment of circulating and intestinal metabolites induced by HS account for the alterations of the jejunal microbiota. To address these questions, jejunal digesta, mucosa, and plasma samples from cows exposed to heat stress (HS: 28°C, temperature-humidity-index (THI) = 76, n = 10), or control conditions (CON: 16°C, THI = 60, n = 10), or pair-feeding (PF: 16°C, THI = 60, n = 10) for 7 days were collected. Digesta fluids were examined for pH, acetate, non-esterified fatty acids (NEFA), glucose, and lactate, whilst plasma metabolites were analyzed for glucose, lactate, beta-hydroxybutyrate (BHB), triglycerides, NEFA, creatinine and urea. The microbiota composition of digesta and mucosa samples were analyzed by 16S rRNA sequencing. The alpha diversity was higher in mucosa than digesta, but not affected by high ambient temperatures. However, the mucosa-associated microbiota appears more prone to ambient heat than the digesta microbiome. Furthermore, HS cows showed a greater mucosal abundance of Bifidobacteriaceae, Succinivibrionaceae UCG-001, Clostridia and a trend for Lactobacillus compared to CON cows. In the digesta, lower abundance of Colidextribacter and a trend for lower Lachnospiraceae UCG-008 were found in HS than CON cows. Several correlations between plasma or intestinal metabolites and microbiota were elucidated, including Methanobacteriaceae correlating positively with plasma BHB and digesta glucose concentrations. The shifts in the microbial profile of the small intestine give some implications for the adaptive responses under HS conditions. Moreover, the reduction in feed intake during HS had non-negligible effects on microbial diversity and the abundance of certain taxa, underpinning the importance of nutrient supply on maintaining intestinal homeostasis.
Assessment of Genetic Relation for Different Ploidy Levels of Aegilops and Triticum Possessing Different Genome-Bearing Species using Start Codon Target Marker
Authors: Ahmad Nariman Salih
Published: July 2023

The Fertile Crescent of Southwest Asia holds high genetic diversity of crop species of the grass tribe Triticeae, which provide staple food for the majority human population. Genetic diversity and their relationships were studied among 51 accessions from Aegilops and Triticum species from Iraqi Kurdistan. Eighteen SCoT markers were used to generate a total of 139 alleles. The discriminating power of the markers was assessed with polymorphism information content (PIC) and marker index (MI), that valued at 0.56 and 3.7, respectively. These results indicate the informativeness of the markers used for studying genetic diversity among the Aegilops and Triticum species. A high level of diversity was identified among the accession, to separate three distinct groups based on the SCoT data. All the accessions from different species with an ‘A’ genome were clustered together in a group, including Aegilops tauschii (possessing D genome). While the other Aegilops (U genome) were clustered in the other two groups. Analysis of molecular variance (AMOVA) partitioned 62% of variability among populations, while 38% of variation was considered between accessions within populations. Principal coordinate analysis (PCoA) for SCoT data showed that the first two components clarified 54.73% of the total variation, indicating consistent patterns of genetic relationships between the accessions. Genetic relationships inferred from UPGMA dendrogram analysis were matched with the PCoA, indicating that the grouping patterns of the accessions were in agreement with their botanical classifications. These results obtained could allow for future insight into wheat breeding programs.
Experiences of Nursing Students Who Are Victims of Dating Violence: a Qualitative Study
Authors: BARROSO-CORROTO Esperanza , LAREDO-AGUILERA José Alberto , COBO-CUENCA Ana Isabel , Carmona-Torres Juan Manuel
Published: July 2023

Background: Dating Violence (DV) is a type of Intimate Partner Violence that occurs between young people, and they are those behaviours that cause physical, sexual or psychological harm.
Objective/Aim: to know the experience of university students around dating violence.
Design and Methods: Qualitative study with a phenomenological approach was conducted through semi-structured individual interviews with nursing students’ victims of dating violence with the same starting categories. The public involve in this study were nursing students who freely agreed to participate in the interviews and gave their informed consent.
Reporting Method: the present study has adhered to relevant EQUATOR guidelines COREQ.
Results: Eleven nursing students participated, the sample was heterogeneous for gender and sexual diversity. Obtaining results about their experience with dating violence, manifestations of dating violence and cyber violence in their relationships, consequences, formal and informal help seeking and proposals for help as nursing students, among others.
Conclusion: Dating violence is a serious problem that seriously affects the victims and requires the creation of prevention programs. The experiences of university students about DV are mainly painful experiences, with serious consequences for those involved, needing help from their close environment and professional help to overcome the problems generated by their partners.
Implications: It is important due to the high prevalence of this phenomenon, also among nursing students, to provide key points to future health professionals and victims of dating violence on the correct way to act against violence due to lack of knowledge on the subject. This study clarifies the experiences of dating violence and how to offer help to victims from the informal and professional sphere.
Trial Registration: This study was approved by the Ethics Committee of Clinical Research of the Health Area of Talavera de la Reina (Toledo) with code 01/2021.
Primary Liver Rhabdomyosarcoma in a Burnt-out disease: An unusual presentation
Authors: Vadisetti Satya Niharika , Patkar Shraddha , Pai Trupti , Qureshi Sajid
Published: July 2023

Rhabdomyosarcoma is the most common soft tissue sarcoma in children. However, Primary hepatic RMS is rare and less than 20 cases are reported in literature. We present the case of a neonate who presented to us with a lumbar mass and lost follow-up during COVID pandemic. She came back to us with a Primary liver Rhabdomyosarcoma in the setting of a burnt out disease. In the setting of a diagnostic dilemma, we found histopathology as the cornerstone to diagnosis. Multimodality therapy based on the experience of similar case reports is the answer is such rare cases where specific guidelines are not yet defined.
Serum tau protein elevation in migraine: a cross-sectional case- control study
Authors: Overeem Lucas Hendrik , Raffaelli Bianca , Fleischmann Robert , Süße Marie , Vogelgesang Antje , Maceski Aleksandra Maleska , Papadopoulou Athina , Ruprecht Klemens , Su Wendy , Koch Mirja , Siebert Anke , Arkuszewski Michal , Tenenbaum Nadia , Kuhle Jens , Reuter Uwe
Published: July 2023

Background: Migraine is a disorder associated with neuropeptide release, pain and inflammation. Tau protein has recently been linked to inflammatory diseases and can be influenced by neuropeptides such as CGRP, a key neurotransmitter in migraine. Here, we report serum concentrations of total-tau protein in migraine patients and healthy controls.
Methods: In this cross-sectional study, interictal blood samples from n=92 patients with episodic migraine (EM), n=93 patients with chronic migraine (CM), and n=42 healthy matched controls (HC) were studied. We assessed serum total-tau protein (t-tau), and for comparison neurofilament light chain protein (NfL), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase L (UCH-L1) concentrations using the Neurology 4-plex kit, on a single molecule array HD-X Analyzer (Quanterix Corp Lexington, MA). Matched serum/cerebrospinal fluid (CSF) samples were used for post-hoc evaluations of a central nervous source of relevant findings. We applied non-parametric tests to compare groups and assess correlations.
Results: Serum t-tau concentrations were elevated in EM [0.320 (0.204 to 0.466) pg/mL] and CM [0.304 (0.158 to 0.406) pg/mL] patients compared to HC [0.200 (0.114 to 0.288) pg/mL] (p=0.002 vs. EM; p=0.025 vs. CM). EM with aura [0.291 (0.184 to 0.486 pg/mL); p= 0.013] and EM without aura [0.332 (0.234 to 0.449) pg/mL; p=0.008] patients had higher t-tau levels than HC but did not differ between each other. Subgroup analysis of CM with/without preventive treatment revealed elevated t-tau levels versus HC only in the non-prevention group [0.322 (0.181 to 0.463) pg/mL; p=0.009]. T-tau was elevated in serum (p=0.028) but not cerebrospinal fluid (p=0.76). In contrast to t-tau, all proteins associated with cell damage (NfL, GFAP, and UCH-L1), did not differ between groups.
Discussion: Migraine is associated with t-tau elevation in serum but not in the CSF. Our clinical study identifies t-tau as a new target for migraine research.
The association of dietary glycemic index and glycemic load with risk of irritable bowel syndrome
Authors: Reisian Mahnaz , Milajerdi Alireza , Keshteli Ammar Hassanzadeh , Abbasi Fatemeh , Haghighatdoost Fahimeh , Azadbakht Leila , Esmaillzadeh Ahmad , Adibi Peyman
Published: July 2023

Purpose
To date, no existing research has explored the potential relationship between dietary Glycemic Index (GI) and Glycemic Load (GL) and the risk of developing Irritable Bowel Syndrome (IBS). Our objective was to examine this association within a substantial sample of Iranian adults.
Method
This study was conducted on 3363 general public adults in Isfahan, Iran. A validated dish-based 106-item semi-quantitative food frequency questionnaire was used to examine dietary GI and GL. The presence of IBS was explored using a modified Persian version of the ROME III questionnaire. Totally, 22.2% (n = 748) of study participants had IBS.
Result
Participants with the highest dietary GI, had higher odds for IBS than those in the lowest category (OR: 1.34; 95% CI: 1.03–1.75). However, the association became non-significant after controlling for potential confounders (OR: 1.14; 95% CI: 0.81–1.61). A positive significant association was found between dietary GI and odds of IBS-constipation predominant (IBS-C) (OR: 1.96; 95% CI: 1.09–3.52), but not with IBS-diarrhea predominant (IBS-D) (OR: 0.78; 95% CI: 0.43–1.40).
Conclusions
No substantial link was observed between dietary glycemic load (GL) and the risk of overall irritable bowel syndrome (IBS) or its subtypes. However, a positive correlation was discovered between dietary GI and IBS with constipation (IBS-C).
Endophthalmitis caused by Burkholderia cepacia complex (BCC): Clinical characteristics, antibiotic susceptibilities, and treatment outcomes
Authors: Beca Flavius A , Sengillo Jesse D , Robles-Holmes Hailey K , Iyer Prashanth G , Miller Darlene , Yannuzzi Nicolas A , Flynn Harry W
Published: July 2023

Purpose To report the clinical characteristics, antibiotic susceptibilities, and review the literature of Burkholderia cepacia complex (BCC) associated endophthalmitis.Study design: Retrospective, observational case seriesMethods Clinical and microbiology records were reviewed for patients evaluated at the Bascom Palmer Eye Institute and diagnosed with culture-confirmed endophthalmitis due to BCC. Antibiotic susceptibility profiles were generated using standard microbiologic protocols via an automated VITEK system.Results Endophthalmitis associated with BCC was diagnosed in three patients. Infection occurred in the setting of post-penetrating keratoplasty (PKP), glaucoma filtering surgery, and suspected trauma. All isolates demonstrated in vitro susceptibility to ceftazidime and meropenem. Presenting visual acuity (VA) ranged from hand motion to light perception. Initial treatment strategies included intravitreal ceftazidime (2.25 mg/0.1 mL) and vancomycin (1.0 mg/0.1mL) injections with fortified topical antibiotics in 2 patients, and surgical debridement of a corneoscleral melt with patch graft along with both topical fortified antibiotics oral antibiotics in the third patient. In all 3 patients, there was no VA improvement at last follow-up, as 2 eyes ultimately underwent enucleation and 1 eye exhibited phthisis bulbi at last follow-up. BCC related endophthalmitis was reviewed among 13 reports. Treatment outcomes were generally poor and antibiotic resistance was common. These BCC isolates cases demonstrated broad resistance patterns, with susceptibilities to ceftazidime (58%), ciprofloxacin (53%), and gentamicin (33%).Conclusions Endophthalmitis caused by B. cepacia is a rare clinical entity with generally poor visual outcomes despite prompt treatment with appropriate antibiotics.
Relaxation of mitochondrial hyperfusion in the diabetic retina via N6-furfuryladenine confers neuroprotection regardless of glycaemic status.
Authors: Anderson Aidan , Alfahad Nada , Wimalachandra Dulani , Bouzinab Kaouthar , Rudzinska Paula , Wood Heather , Fazey Isabel , Xu Heping , Lyons Timothy J. , Barnes Nicholas M. , Narendran Parth , Lord Janet M. , Rauz Saaeha , Ganley Ian G. , Curtis Tim M. , Wallace Graham R. , Hombrebueno Jose R.
Published: July 2023

The recovery of mitochondrial quality control (MQC) may bring innovative solutions for neuroprotection, while also imposing an extraordinary challenge given the need of holistic approaches to restore mitochondrial dynamics (fusion/fission) and turnover (mitophagy and biogenesis). In Diabetic Retinopathy (DR) this therapeutic approach is further compounded by our lack of understanding of human retinal neurodegeneration, but also of how MQC processes interplay during disease progression. Here, we show for the first time that mitochondria remodel towards hyperfusion during retinal neurodegeneration in human and murine diabetes. Using Mito-QC reporter, we demonstrate that mitochondrial hyperfusion blunts the homeostatic turnover of mitochondria in diabetes, causing metabolic, neuronal, and neuro-inflammatory (glial) stress. By mimicking this mitochondrial remodelling in vitro, we also generated a drug discovery platform whereby glycosylated N6-furfuryladenine(s) (but not other PINK1-activators) restored mitochondrial turnover and cellular bioenergetics by relaxing hyperfusion in a controlled fashion. Oral administration of glycosylated N6-furfuryladenine restored mitochondrial turnover in the murine (Ins2Akita) diabetic retina, improving clinical correlates (electroretinogram and SD-OCT) and conferring human-relevant neuroprotection regardless of glycaemic status. Collectively, our study provides new translational insights for neuroprotection in the diabetic retina through the holistic recovery of MQC.
Comparitive Study Between Different Frequency Analysis Methods Over Tidal Data
Authors: Kumar Tanmay
Published: July 2023

Decomposition of tidal frequencies of port 8443970 Boston, Massachusetts1, USA, into sinusoidal components due to the lunar phase and rotation of the earth. Effect of the rotation of earth was apparent through a RFFT2,3 frequency decomposition and the highest contributing frequency was 2.0 times per day, following the sublunar / antipodal nature of tides; A lowpass Butterworth filter4,5 was applied to the mean normalized tidal data in order to gauge effect of lunar phase on magnitude of tides. The output data was passed through RFFT, the highest contributing frequency was found to be 0.06896 times per day, which corresponds roughly to twice a month, this matches with the 2 sets of neap and spring tide during a lunar cycle. The above process was repeated with Welch’s Method6 and the Lomb-Scargle method. All three of them, independently lead to the same result, adding further veracity to the analysis. A comparison between the efficiency of the 3 methods was done using a profiler.