bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeting blood-brain barrier leakage for visualizing , monitoring, and evaluating ischemia reperfusion injury with Rus-Tc99m Probe
Authors: Gong Shuaishuai , Wang Jieman , Chen Zhuo , Pan Xuewei , Wu Yunhao , Zhang Yuanyuan , Yu Boyang , Li Fang , Kou Junping
Published: May 2020

Background : Cerebral ischemia-reperfusion (I/R) injury as a serious threat to human health is characterized by cerebral endothelial leakage, as a result of the damage of blood-brain barrier (BBB). It is thus quite attractive to realize real-time monitoring of BBB damage for therapeutic surveillance.Methods : In this study, a radioactive probe is constructed by conjugating ruscogenin (Rus), a neuroprotectants, to technetium-99m (Tc 99m ) to assess the damage of cerebral endothelial in BBB.Results : In vitro study proves that the probe can penetrate more efficiently in damaged BBB. Then, longitudinal nuclear imaging distinguishes mice with BBB leakage from normal ones, which is validated by evans blue staining of brain tissue. Higher nuclear signal also correlates with poorer blood circulation in brain. Further, by visualizing brain signal during drug treatment, the probe finds that the most obvious protective efficacy of Rus occurs at 12 h post administration, which is superior than edaravone (Edara).Conclusion : Altogether, the probe is promising to monitor I/R injury real-time by radioactive-imaging of BBB integrity. Importantly, Rus as a neuroprotectants may serve as a potential theranostic agent for I/R treatment.
A Systematic Review and Meta-Analysis on the Relation Between Helicobacter Pylori Infection and Atherosclerosis in the Iranian Population
Authors: Keikha Masoud , Karbalaei Mohsen
Published: May 2020

Background: Various evidences have recently been provided indicating the relationship between infection with Helicobacter pylori and the extra-gastric complication, especially atherosclerosis. Atherosclerosis is the most important predisposing factor for cardiovascular disorders due to the high prevalence of cardiovascular disorders in developing countries (areas where a high population of people are infected with Helicobacter pylori), in particular in Iran.Methods: In a current systematic review and meta-analysis study, we collected all studies of the isolation of Helicobacter pylori from atherosclerotic plaques in Iranian cardiovascular patients to investigate the presence or absence of a relationship between Helicobacter pylori infection and susceptibility to atherosclerosis. The present meta-analysis was done by Comprehensive Meta-Analysis software (CMA-Ver. 2.0). This software has the ability to combine studies and impact sizes into the results and is highly acceptable.Results: Overall, the frequency of H. pylori in atherosclerotic plaques in the coronary artery disease (CAD) patients was estimated to be 41.30%. However, the highest and lowest frequency of infection with Helicobacter pylori were 80% and 0%, respectively.Conclusions: However generally, regarding the previous studies, we collected all the Iranian published articles and showed that the infection with Helicobacter pylori was significantly related with the atherosclerosis, but further complementary and more extensive studies are required to confirm this hypothesis.
Transcriptome-wide identification and characterization of the MYB gene family in sickle seagrass (Thalassia hemprichii)
Authors: Jie Shen , Zefu Cai , Shiquan Chen , Daoru Wang , Wu Zhongjie
Published: May 2020

Background: Sickle seagrass ( Thalassia hemprichii ) is one of the most important marine plants living in the tropical climate, mainly distributed in Southeast Asian waters. It is an important food source for marine herbivores and plays important roles in nitrogen fixation, water purification and maintaining the balance of marine ecology. In recent years, the area of aquatic plants has declined rapidly, affecting the ecological balance. However, the molecular mechanism of aquatic plants has been poorly studied.Results: In this study, all transcriptional information of T. hemprichii was obtained by using high-throughput sequencing technology, and 32,097 unigenes were identified by annotation. In addition, 119 MYB transcription factors were screened, and 61 genes with complete ORF were sequenced. Furthermore, 17 clays were identified according to the information of Arabidopsis .Conclusions: This study provides useful information for enriching the genetic information of T. hemprichii , and further exploring the molecular mechanisms of the evolution, development, and physiological functions of Sickle seagrass.
Risk factors for recurrent wheezing after bronchiolitis in infants: 2-year follow up in China
Authors: Chen Sainan , Gu Wenjing , Wu Min , Hao Chuangli , Zhu Canhong , Shao Xuejun , Wang Yuqing
Published: May 2020

Objective: To investigate the incidence of post-bronchiolitis recurrent wheezing and the risk factors.Methods: Infants with bronchiolitis were enrolled from November 2016 through March 2017. 24 healthy children were enrolled as the control group. Nasopharyngeal aspirates were obtained for detecting respiratory virus including by using RT-PCR and direct immunofluorescent assay. The serum levels of cytokine including TSLP, IL2, IL13, TIMP-1, MMP-9, IL33, IL5, IL4, IL25, TNF- α and MIP-1α were measured by using flow cytometry. The patients were followed every 3 months for a duration of 2 years by telephone or outpatient.Results: 1. 89 infants were enrolled, of which 81 patients were successfully followed up. 2. 22.2% of the patients experienced recurrent wheezing episodes. 3. The proportion of eczema, systemic glucocorticoid treatment and patients with moderate to severe condition were significantly higher in recurrent wheezing group than in non-recurrent wheezing group (52.4% vs 83.3%; 36.5% vs 66.7%; 33.3% vs 61.1%, respectively, both P<0.05); The serum level of TNF- α was lower in recurrent wheezing group (P< 0.05) ;The serum levels of IL-4、IL-5、IL-25、IL-33 were significantly higher among patients without recurrent wheezing (P< 0.05). 4. Logistic regression analysis showed that eczema was an independent risk factor for post-bronchiolitis recurrent wheezing (OR=7.488; 95% CI, 1.447-38.759; P=0.016). Conclusion: The prevalence of recurrent wheezing among infants after bronchiolitis was 22.2% in 2-year follow-up. Eczema is the only independent risk factor and no correlation was found between the specific virus and disease severity with post-bronchiolitis recurrent wheezing.This work was supported by the National Natural Science Foundation of China, No.81573167; Jiangsu Science and Technology Department, No. BE2017657; Science and Technology Project of Suzhou, No. SYSD2017092; No. LCZX201809
Three-dimensional laparoscopic partial nephrectomy for renal hilar tumors: an empirical analysis of 290 patients
Authors: Yang Feiya , Mou Lianjie , Xing Nianzeng
Published: May 2020

Objective To explore the feasibility of laparoscopic partial nephrectomy(LPN) in the treatment of renal hilar tumors. Methods Clinical data of 290 patients undergoing laparoscopic partial nephrectomy from January 2013 to August 2019 were retrospectively analyzed, including 27 patients with renal hilar tumors and 263 patients with non-hilar renal tumors. Perioperative data and follow-up results were compared between the two groups. Results Tumor size in Group A is smaller(2.97±0.88 vs 3.55±1.46,p<0.05), R.E.N.A.L. nephrometry score of Group A is higher(8.4±1.3 vs 6.5±1.7,p<0.01).The operation time, WIT and intraoperative blood loss in the Group A were slightly higher, but with no statistical difference (p>0.05). There was no significant difference between the two groups in intraoperative ultrasound rate, collection system repair rate, drainage time,postoperative hospital stay, and eGFR changes (p>0.05).The median follow-up period was 40 months. One patient with postoperative pathologic report of angiomyolipoma was found tumor recurrence and was currently undergoing regular reexamination. Conclusion Three-dimensional laparoscopic partial nephrectomy for renal hilar tumors is safe and feasible after detailed preoperative evaluation of the tumor and selection of appropriate surgical strategies.
Phenology Modelling and Forest Disturbance Mapping with Sentinel-2 time series in Austria
Authors: Löw Markus , Tatjana Koukal
Published: May 2020

Background Worldwide, forests provide natural resources and ecosystem services. However, forest ecosystems are threatened by increasing forest disturbance dynamics, caused by direct human activities or an altering natural environment. It is decisive to trace the intra- to trans-annual dynamics of these forest ecosystems. National to local forest communities request detailed area-wide maps that delineate forest disturbance dynamics at various spatial scales. Methods We developed a remote sensing based time series analysis (TSA) framework that comprises data access, data management, image pre-processing, and an advanced but flexible TSA. The data basis is a dense time series of multispectral Sentinel-2 images with a spatial resolution of 10 metres. We use a dynamic Savitzky-Golay-filtering approach to reconstruct robust but sensitive phenology courses. Deviations from the latter are further used to derive spatiotemporal information on forest disturbances. In a first case study, we apply the TSA to map forest disturbances directly or indirectly linked to recurring bark beetle infestation in Northern Austria. Finally, we use zonal statistics on different spatial scales to provide aggregated information on the extent of forest disturbances between 2018 and 2019.Results and Conclusion The outcomes are a) individual phenology models and deduced phenology metrics for each 10 metres by 10 metres forest pixel in Austria and b) forest disturbance maps useful to investigate the occurrence, development and extent of bark beetle infestation. The phenology modelling results provide area-wide consistent data, also useful for downstream analyses (e.g. forest type classification). Results of the forest disturbance detection demonstrate that the TSA is capable to systematically delineate disturbed forest areas. Information derived from such a forest monitoring tool is highly relevant for various stakeholders in the forestry sector, either for forest management purposes or for decision-making processes on different levels.
Combinatorial analyses reveal that cellular composition changes have different impact on transcriptomic changes of cell type specific genes in Alzheimer’s Disease brains
Authors: Xiang Shunian , Johnson Travis , Dong Tianhan , Huang Zhi , Cheng Michael , Wang Tianfu , Yang Kai , Ni Dong , Huang Kun , Zhang Jie
Published: May 2020

Background

Alzheimer’s disease (AD) brains are characterized by progressive neuron loss and gliosis which involves mostly microglia and astrocytes. Comparative transcriptomic analysis on AD vs. normal brain tissues helps to identify key genes/pathways involved in AD initiation and progression. However, many such studies using bulk brain tissue samples have not considered cell composition changes in AD brains, which may lead to expression changes that are not due to transcriptional regulation.

Methods

Using five large transcriptomic datasets including 1,681 brain tissue samples (882 AD, 799 normal) in total, we first mined frequent co-expression network modules across them, then combined differential expression and differential co-expression analysis on the mined modules in AD versus normal brains. Integrated with cell type deconvolution analysis, we addressed the question of whether the module expression changes are due to altered cellular composition or transcriptional regulation. We then used four additional large AD/normal transcriptomic datasets to validate our findings.

Results

The integrative analysis revealed highly elevated expression level of microglia modules in AD without co-expression change. Decreased expression and elevated co-expression are observed for neuron modules in AD, while significant over-expression and co-expression perturbation are observed in astrocyte modules, all of which has not been previously reported. The expression levels of astrocyte modules also show the strongest correlation with the clinicopathological biomarkers among all cell type specific modules.

Conclusion

Further analysis indicated that the overall increased expression of the core microglia modules can be well explained by the increased microglia cell population in AD brains instead of bona fide microglia genes’ upregulation. In contrast, the decreased expression and perturbed co-expression in AD neuron modules are due to both neuron cell loss and expression regulation of neuronal pathways including differentially expressed transcription factors such as BCL6 and STAT3, which previous study was not able to identify from the shadow of the cellular composition change. Similarly, the strong changes in expression and co-expression in the astrocyte modules may be also due to a combinatory effect from astrogliosis and astrocyte gene activation in AD brains. In this work, we demonstrated that the combinatorial analyses not only provide a powerful approach to delineate the origin of transcriptomic changes in bulk tissue data, but also lead to a deeper understanding of genes in AD.
Do we really have a lack of ventilators?
Authors: Nosáľ Vladimír
Published: May 2020

The pandemia of COVID-19 is considered as „ventilator dependent“ disease. In a short study there are presented data from Switzerland showing that there was only short period of time when most of ventilators were needed, and moreover, their lack is highly probably not associated with increased frequency of deaths. COVID-19 showed us, that others parameters such as number of hospitalizations, patients on ICUs and ventilated patients may be important epidemiological markers.
Variations In Trim5α And Cyclophilin A Genes Among HIV-1 Elite Controllers and Non Controllers In Uganda; A Laboratory-Based Cross-sectional Study
Authors: Amanya Sharon Bright , Nyiro Brian , Wasswa Francis , Obura Bonniface , Nakabazi Rebecca , Nabulime Eva , Katabazi Shaba Fred , Nabatanzi Rose , Bayiyana Alice , Mboowa Gerald , Kayongo Alex , Wayengera Misaki , Sande Obondo J
Published: May 2020

Background Tripartite Motif Containing 5 alpha (TRIM5α), a restriction factor produced ubiquitously in cells and tissues of the body plays an important role in the immune response against HIV. TRIM5α targets the HIV capsid for proteosomal destruction. Cyclophilin A, an intracellular protein has also been reported to influence HIV infectivity in a cell-specific manner. Accordingly, variations in TRIM5α and Cyclophilin A genes have been documented to influence HIV-1 disease progression. However, these variations have not been documented among Elite controllers in Uganda and whether they play a role in viral suppression remains largely undocumented. Our study focused on identifying the variations in TRIM5α and Cyclophilin A genes among HIV-1 Elite controllers and non-controllers in Uganda.Methods PBMCs previously collected from HIV-1 Elite controllers and non-controllers were thawed, CD4+ T cells isolated and then cultured in presence of Anti-CD3 & Anti-CD28 for 48 hours in a CO2 incubator. RNA was extracted and RT qPCR was done using QuantiTect Probe RT-PCR Kit in a Rotor gene Q real-time PCR machine. mRNA was quantified using the delta CT relative quantification method. DNA was extracted using Qiagen Blood Genomic DNA Kit, PCR amplified and sequenced the exon 2 of TRIM5α and the promoter region of the CyclophillinA gene. Sequence data were analyzed using Mutation Surveyor to identify Single Nucleotide Polymorphisms (SNPs).Results From the sequence analysis, the rs10838525 G>A mutation in exon 2 of TRIM5α was found only among elite controllers (30%) while the rs3824949 was seen among 25% of the non-controllers. In the Cyclophilin A promoter, rs6850 was seen among 62.5% of the non-controllers and only among 10% elite controllers. rs17860048 was predominantly seen among elite controllers (30%) and 12.5% non-controllers. From gene expression analysis, we noted that the respective genes were generally elevated among elite controllers, however, this difference was not statistically significant (TRIM5α p=0.6095; Cyclophilin A p=0.6389).Conclusion Variations in TRIM5α and Cyclophillin A promoter may influence HIV viral suppression. The rs10838525 SNP in TRIM5α may contribute to viral suppression among HIV-1 elite controllers. The rs6850 in the cyclophillin A gene may be responsible for HIV-1 rapid progression among HIV-1 non-controllers.
COVID-19 Outbreak Prediction with Machine Learning
Authors: Ardabili Sina F. , Mosavi Amir , Ghamisi Pedram , Ferdinand Filip , Varkonyi-Koczy Annamaria R. , Reuter Uwe , Rabczuk Timon , Atkinson Peter M.
Published: May 2020

Several outbreak prediction models for COVID-19 are being used by officials around the world to make informed-decisions and enforce relevant control measures. Among the standard models for COVID-19 global pandemic prediction, simple epidemiological and statistical models have received more attention by authorities, and they are popular in the media. Due to a high level of uncertainty and lack of essential data, standard models have shown low accuracy for long-term prediction. Although the literature includes several attempts to address this issue, the essential generalization and robustness abilities of existing models needs to be improved. This paper presents a comparative analysis of machine learning and soft computing models to predict the COVID-19 outbreak as an alternative to susceptible-infected-recovered (SIR) and susceptible-exposed-infectious-recovered (SEIR) models. Among a wide range of machine learning models investigated, two models showed promising results (i.e., multi-layered perceptron, MLP, and adaptive network-based fuzzy inference system, ANFIS). Based on the results reported here, and due to the highly complex nature of the COVID-19 outbreak and variation in its behavior from nation-to-nation, this study suggests machine learning as an effective tool to model the outbreak. This paper provides an initial benchmarking to demonstrate the potential of machine learning for future research. Paper further suggests that real novelty in outbreak prediction can be realized through integrating machine learning and SEIR models.
Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non- human primates
Authors: Maisonnasse Pauline , Guedj Jérémie , Contreras Vanessa , Behillil Sylvie , Solas Caroline , Marlin Romain , Naninck Thibaut , Pizzorno Andres , Lemaitre Julien , Gonçalves Antonio , Kahlaoui Nidhal , Terrier Olivier , Fan Raphael Ho Tsong , Enouf Vincent , Bosquet Nathalie Dereuddre- , Brisebarre Angela , Toure Franck , Chapon Catherine , Hoen Bruno , Lina Bruno , Calatrava Manuel Rosa , Werf Sylvie van der , Lamballerie Xavier de , Grand Roger Le
Published: May 2020

COVID-19 has become a pandemic that has caused over 200,000 deaths worldwide, with no antiviral drug or vaccine yet available. Several clinical studies are ongoing to evaluate the efficacy of repurposed drugs that have demonstrated antiviral efficacy in vitro. Among these candidates, hydroxychloroquine (HCQ) has been given to thousands of individuals worldwide but definitive evidence for HCQ efficacy in treatment of COVID-19 is still missing.We evaluated the antiviral activity of HCQ both in vitro and in SARS-CoV-2-infected macaques. HCQ showed antiviral activity in monkey African green monkey kidney (VeroE6) cells but not in a model of reconstituted human airway epithelium. In macaques, we tested different treatment strategies in comparison to placebo, before and after peak viral load, alone or in combination with azithromycin (AZTH). Neither HCQ nor HCQ+AZTH showed a significant effect on the viral load levels in any of the tested compartments. When the drug was used as a pre-exposure prophylaxis (PrEP), HCQ did not confer protection against acquisition of infection.Our findings do not support the use of HCQ, either alone or in combination with AZTH, as an antiviral treatment for COVID-19 in humans.
TUTELAS DE URGÊNCIA E OS DIREITOS FUNDAMENTAIS SOB A VISÃO CONSTITUCIONAL DO PROCESSO CIVIL
Authors: OLIVER Renata Cristina Faria
Published: May 2020

O presente trabalho tem como objeto central o estudo dos direitos fundamentais e das tutelas de urgência em face dos princípios do prazo razoável e do contraditório, e como são conceituadas as medidas cautelares e antecipatórias, bem quais são suas destinações e aplicabilidade frente ao direito processual civil, sempre ponderando sobre a efetividade do provimento jurisdicional em razão da morosidade da justiça. Na pesquisa foi utilizado o método hipotético-dedutivo, que se desenvolve de modo investigativo com levantamento de informações constantes em livros, legislação e jurisprudência. A pesquisa demonstra a importância da ponderação quanto a efetividade do provimento jurisdicional face a longa duração do processo e como as tutelas de urgência podem ser manejadas a fim de resguardar o direito tutelado ou antecipar o os efeitos da tutela, sem que tais medidas afrontem os princípios fundamentais e o contraditório, buscando a eficácia e celeridade processual.
Blaming the Victim: Alienasi Gender dalam Media Online
Authors: Lestari Anna Puji
Published: May 2020

Bebagai data menunjukkan bahwa jumlah kasus pemerkosaan di Provinsi Jawa Tengah masih tergolong tinggi sehingga perlu mendapat perhatian dari semua pihak terkait. Berbagai kasus pemerkosaan di Jateng tak luput diberitakan oleh berbagai media massa, salah satunya adalah Suaramerdeka.com. Suaramerdeka.com merupakan media online lokal berbasis media cetak pertama di Indonesia. Bertitik tolak dari realita tersebut, penelitian ini dilakukan. Penelitian ini menggunakan pendekatan kualitatif dalam paradigma kritis dengan desain analisis isi framing Entman. Hasil penelitian menunjukkan bahwa berita kekerasan seksual di Suaramerdeka.com banyak menggunakan sudut pandang Blaming the Victim, indikasinya adalah terjadinya Alienasi Gender. Alienasi Gender merupakan konsep penting berdasarkan temuan dari penelitian ini yang menjelaskan bahwa korban kekerasan seksual ataupun pihak-pihak yang membela korban disingkirkan pendapatnya sebagai narasumber berita. Selain itu, juga terdapat pemilihan diksi bias yang mengukuhkan terjadinya Blaming the Victim berita-berita di media online. Pemilihan diksi bias dan praktik Alienasi Gender merupakan wujud kekerasan simbolik siber. Kekerasan Simbolik Siber menggambarkan kekerasan yang terjadi karena dominasi bahasa berita media di dunia maya.

***

The number of rape victims in Central Java is very high so that need to gain attention from various parties. Many rape news in Central Java have been reported by numerous mass media, Suaramerdeka.com is one of them. Suaramerdeka.com is the first online local media based on printed media in indonesia. Based on that reality, this researched was conducted. This research is qualitative with critical paradigm on Framing Entman design. This research results show that many sexual assault news on Suaramerdeka.com used Blaming the Victim point of view. The indication is Gender Alienation practice took place. Gender Alienation is important concept based on this research which explain that the opinion of rape victims and the victim defenders were alienated as news resources. Beside that, bias diction was choosen on rape news that strengthen Blaming the Victim news on online media. Gender Alienation Practice and bias diction is Cyber Symbolic Violence. Cyber Symbolic Violence picturized violence that took place because of languange domination on online media.
Analisis Dampak Integrasi Data terhadap Kecepatan Pelayanan Publik di Kota Surabaya
Authors: Dewi Renny Sari
Published: May 2020

Since 2013, through Surabaya Single Window (SSW), the Government of Surabaya City has implemented the innovation of public service (electronic government, e-Government) to integrate residence data to the applicant with domicile of Surabaya. Synergy between information technology and public services, the authors suspect there is positive impact of access speed of e-Government after the integration of population data. A mount of 151 respondents have been surveyed when fill-in the SSW application for technical permissions to capture its response time. The researcher concludes that data integration factor through JSON data service technology can accelerate the process of filling data of population equal to 80.7 percent or equal 56.98 seconds faster. It means, if citizenship data integration is implemented thoroughly, the Public Service Integrated Unit (UPTSA) may be able to receive 2.850 application files per day.
Analisis Implementasi E-Bugdeting dengan Menggunakan Model CIPP pada Pemerintah Provinsi DKI Jakarta
Authors: Rahman Rama Andika Thio
Published: May 2020

This study aimed to analyse the effectiveness of e-Budgeting implementation in the Provincial Government of DKI Jakarta by using CIPP (Context, Input, Process, and Product) model from Stufflebeam (2003). The type of this research was a qualitative research using case-study approach.  The data were collected using interviews and documentation studies. The results of this study revealed that the implementation of e-Budgeting in DKI Jakarta Provincial Government was feasible to proceed as it was proven to be effective when viewed from the four components of CIPP Model that is context which focuses on the success of achieving the initial goal of budget transparency and accountability. Furthermore, in terms of inputs, the use of facilities, infrastructure and human resources was adequate. Viewed from the process, e-Budgeting simplified and minimized errors in the process of preparing the work plan and budget (RKA). From the output (Product), it improved the quality of regional budget (APBD) in terms of conformity with the Regional Medium-Term Development Plan (RPJMD) document and the control management of budget that plays an active role.
IT GOVERNANCE EVALUATION USING COBIT 5 FRAMEWORK ON THE NATIONAL LIBRARY
Authors: Andry Johanes Fernandes , Setiawan Ari Kurnia
Published: May 2020

National Library of Indonesia (NLI) is a public library located in Jakarta that was established in 1980 by the decree of Ministry of Education and Culture. This day NLI has already applied digitalization of its contents and its management with IT, IT has been an important aspect in an organization. The objective of IT implementation is to increase effectivity and performance in organization. In order to get maximum results good IT Governance is needed in order to align IT with business, the better IT Governance the greater outcome that the organization will get. The objective of this research is get an overview about the level of IT Governance on going, the analysis tool will be used is COBIT 5 focusing on DSS domain. The average score of DSS01, DSS02 and DSS 03 is in 1.2 to 1.6 and for the DSS04, DSS05 and DSS06 domain the average score is between 2.1 and 2.4
INFORMATION SHARING AND MECHANISM IN ONLINE COMMUNITY
Authors: Andriane Septiane , Pinem Ave Adriana , Handayani Putu Wuri
Published: May 2020

The emergece of C2C (customer to customer) community in e-commerce platform is expected to boost the number of SME moving to online plaform. Since the community could provide information and experience required by new e-commerce players. This study aims to analyse what information is shared by members in C2C community and what is the information sharing mechanism that implemented on it. Netnographic study was conducted by observing 1002 posts  from the Bukalapak community for six months. As Bukalapak is one of the largest C2C platfom in Indonesia. The result shows that the information shared could be classified by keyword in to five classes, namely categories of tips and tricks, ideas and problems with third parties, ideas and problems of features, community, and question and answer. The information category that has not been covered by Bukalapak original categories is and problems with third parties which mentioned in many posts by community member. The mechanisms used to share the information are including, standard, policy, status and reward.
Изменение объема кратковременной памяти под влиянием стрессогенного воздействия у курсантов
Authors: Битюцкая Екатерина В. , Лебедева Наталья А. , Цаликова Юлия Р.
Published: May 2020

Introduction. The effects of moderate-intensity stressors on short-term memory are studied, which is relevant to the professional training of first responders (firefighters) when preparing them for emergencies. This study investigates changes in the capacity of short-term memory under stress. Significant differences were found among memory parameters of fire cadets and students of civilian specialties. To the best of our knowledge, this is the first experimental study of the stress impact on the short-term memory capacity that takes into account professional education and training of the respondents. Methods. The study comprised 90 respondents, including 50 fire cadets of the Academy of State Fire Service and 40 students of Moscow universities. The subjects were divided into an experimental group and three control groups. Stressful stimuli (disturbing photo- and audio materials) were presented to respondents from two groups; respondents in two other groups were presented with neutral stimuli. The short-term memory capacity before and after the stressful stimulation was assessed with the Digit Span Test. The physiological signals of the subjects were measured during the experiment. Results. In fire cadets, stress resulted in a significant increase in memory capacity, while memory capacity showed a slight decrease in students. Physiological response to stressful conditions was different between students and fire cadets. Compared to cadets, the baseline muscle tension measures were higher in students. Compared to students, cardiovascular system parameters (systolic wave amplitude, pulse transit time) changed faster in cadets. However, these parameters changed not as substantially as those in students. Discussion. In fire cadets, memory capacity and its change due to stressful effects were associated with levels of non-verbal intelligence. It might also be mediated by emergency professionals' competencies. The system of selection, psychological training, and counseling of fire cadets in the Academy of State Fire Service is considered to be an important factor in the stability of cognitive functions under stress.
Детерминанты жизнестойкости у трех поколений современной России
Authors: Федотова Вера А.
Published: May 2020

Introduction. Generational differences have been scarcely investigated. The factors that help individuals to cope with stressful factors and increasing tension are worth consideration in the context of present-day reality. This study addresses the predictors of hardiness in different generations of Russians. Methods. A sample of respondents from various regions of the Russian Federation, aged from 18 to 75 years, took part in the empirical study of values, subjective economic well-being, and hardiness factors. The study used the following techniques: (a) the PVQ-R technique for measuring individual values, (b) the Test of Hardiness by D. A. Leont'ev, (c) the Subjective Economic Well-being technique by V. A. Khashchenko, and (d) the Meaning-in-Life Orientations test (MOL) by D. A. Leont'ev), the modified version of the Purpose-in-Life test (PIL). Results. Representatives of generation Y have a higher overall level of hardiness. The external locus of control influences hardiness in all the three examined generations. This influence is positive for generations X and Y, and negative for baby boomers. Economic anxiety has a negative impact on hardiness in representatives of generations X, Y, and baby boomers. The values of individualism – ‘independence: thinking’ and ‘achievement’ – influence hardiness in representatives of generations X and Y. Discussion. Increased dissatisfaction with financial situation, the inability to save money, and increased economic anxiety decrease the level of hardiness in Russians. The increase in financial well-being can contribute to an increase in hardiness across all the groups of respondents. Independence in the choice of actions, ambitious goals in life, the desire to be successful, and the need for feeling safe and secure increase the ability to withstand stress among representatives of generations X and Y.
Why Do We Need New Markers for Male Hypogonadism and How Seminal Proteomics Might Solve the Problem?
Authors: Grande Giuseppe , Milardi Domenico , Baroni Silvia , Urbani Andrea , Pontecorvi Alfredo
Published: May 2020

Male hypogonadism is “a clinical syndrome that results from failure of the testis to
produce physiological concentrations of testosterone and/or a normal number of spermatozoa due
to pathology at one or more levels of the hypothalamic– pituitary–testicular axis”. The diagnostic
protocol of male hypogonadism includes accurate medical history, physical exam, as well as
hormone assays and instrumental evaluation. Basal hormonal evaluation of serum testosterone, LH,
and FSH is important in the evaluation of diseases of the hypothalamus-pituitary-testis axis. Total
testosterone levels < 8 nmol/l profoundly suggest the diagnosis of hypogonadism. An inadequate
androgen status is moreover possible if the total testosterone levels are 8-12 nmol/L. In this “grey
zone” the diagnosis of hypogonadism is debated and the appropriateness for treating these patients
with testosterone should be fostered by symptoms, although often non-specific. Up to now, no
markers of androgen tissue action can be used in clinical practice. The identification of markers of
androgens action might be useful in supporting diagnosis, Testosterone Replacement Treatment
(TRT) and clinical follow-up. The aim of this review is to analyze the main findings of recent
studies in the field of discovering putative diagnostic markers of male hypogonadism in seminal
plasma by proteomic techniques. The identified proteins might represent a “molecular androtest”
useful as a seminal fingerprint of male hypogonadism, for the diagnosis of patients with moderate
grades of testosterone reduction and in the follow-up of testosterone replacement treatment.
Eco-friendly and Enantiospecific Biginelli Synthesis Using (+)-Myrtenal as the Substrate – An Impeccable and Unequivocal Analysis of the Product
Authors: Dias Benincá Luiza Albino , Pereira Ligiéro Carolina Bastos , da Silva Santos Jonas , Junior Joel Jones , da Silva Flavia Martins
Published: May 2020

Background:

We found in the literature, an excellent review of the Biginelli reaction that addresses
the methodologies for obtaining enantiopure dihydropyrimidinones (DHPMs). In 1992, optically pure DHPMs
were obtained by fractional crystallization of the diastereomeric ammonium salt derivative with (S)-(-) and (R)-
(+)-α-methyl benzylamine and by other chiral resolution techniques, such as chiral high-performance liquid
chromatography (HPLC). Asymmetric syntheses of these compounds are also explained in the literature. The
main strategy is to use acid catalysts such as organophosphates, organometallic complexes, amines and
diamines, nanocomposites, and chiral ionic liquids, e.g., L-prolinium sulfate (Pro2SO4).

Objective:

The objective was to study the Biginelli reaction with a chiral aldehyde.

Methods:

A mixture of ethyl acetoacetate (0.26 g, 3 mmol), urea (0.18 g, 3 mmol) and ethyl lactate (EL) (1
mL) was left under heating at 70°C and stirring for 1 h. Next, (-)-(1R)-myrtenal (0.45 g, 3 mmol) was added,
and the medium was heated for 5 h more until the formation of a white solid. Ten millilitres of distilled water
was added, and the product was extracted with CH2Cl2 (3 x 4 mL). The solvent was evaporated, and the
product was recrystallized from ethanol-water.

Results and Discussion:

(+)-Myrtenal was used as a chiral substrate for a study that led to ethyl (R)-4-((1R,5S)-
6,6-dimethylbicyclo [3.1.1]hept-2-en-2-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate by the
Biginelli synthesis using EL as a green solvent. The result is the first example of the enantiospecific Biginelli
reaction. The product was exhaustively characterized by several physical analysis methods, i.e., 1H, 13C and 2D
nuclear magnetic resonance (NMR) spectroscopies, infrared (IR) spectroscopy, mass spectrometry (MS), and
high-resolution MS (HRMS), and its structure was unequivocally elucidated by X-ray crystallography.

Conclusion:

Compound (4R)-4-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)-6-methyl-2-oxo-1,2,3,4- tetrahydropyrimidine-
5-ethyl carboxylate is the first example of the enantiospecific Biginelli reaction. In addition,
the process has the advantage of using EL as a green solvent. The product was characterized by 1H, 13C, and 2D
NMR and IR spectroscopy, MS, HRMS, and X-ray crystallography.
DFT Studies of Distinct Anilines with p-Hydroxycinnamic Acids for Antioxidant Profile
Authors: Kumar Ch. Ravi S. , Jha Anjali , Deepthi Sri
Published: May 2020

Background:

Life style and jobs in current situations have generated increased free
radicals such as hydroxyl (OH•) and superoxide (O2•) radicals, thereby increasing stress in humans.
Interest in search of antioxidants that trap these free radicals has increased to relieve stress.
β-carotene (provitamin A), ascorbic acid (vitamin C), tocopherol or vitamin E, Trolox; butyl hydroxy
toluene and phenolic compounds are the well-known antioxidants. Several methods evaluate
the antioxidant property existing in natural substances (medicinal plants and agri-food products)
and synthetic compounds (2-methyl-3- (pyrrolidin-2-ylideneamino) quinazolin-4 (3H) –one and
3,3'- (1,4- phenylenebis (methanylylidene)) bis (azanylylidene) (2-methyl-quinazolin-4 (3H) -one).

Objective:

The objective of this study is to focus on complexes with p-hydroxycinnamic acids to
trap free radicals in a greener way.

Method:

Spectroscopic shifts and structural studies were employed to attribute electronic properties
responsible for antioxidant profile. Spectroscopic shifts in wavenumbers were attributed with
Fourier Transform Infrared Spectra (FTIR) and Fourier Transform Raman spectra (FT Raman
Spectra). Structural studies were performed with Gaussian package, electron density method the
B3LYP method, basis set 6-31(d) for attributing electronic properties responsible for antioxidant
profile.

Result:

Interpretation of FTIR spectra revealed spectroscopic shifts in wavenumbers in all the
complexes responsible for bonding. Further, studies confirmed the formation of complex with reduced
intensities in Raman spectra. Computational studies revealed enhancement in molecular and
electronic properties responsible for antioxidant power.

Conclusion:

Studies revealed that complex with p-nitroaniline contribute to greater acceptor and
donor power responsible for antioxidant power. These higher powers suggest the best antiradicals
to trap free radicals.
PROTOTYPE PERANCANGAN MEMBUKA DAN MENUTUP PINTU GERBANG RUMAH MENGGUNAKAN MOTOR DC BERBASIS ANDROID
Authors: Irwanto Irwanto , Gustiono Vaka
Published: May 2020

The gate is one of the main security in maintaining a home. Because the gate is the first coating to protect the contents and building of the house. It also did not escape the perpetrators of robbery criminal acts to have a way to overcome the weakness of protection given extra security on the fence. With the development of wireless technology, one of which is cheap and easy-to-use Bluetooth that can be reached by mobile phones that can be reached by all groups, Bluetooth is a facility on cellular telephones that is used to order to open and close doors with a Bluetooth application that is installed on a smartphone. The testing tool system method opens the gate of the house using an Android-based DC motor using an ATMEGA 8 microcontroller consisting of several blocks that are interconnected to one another. The results of the whole set of tools open and close the automatic gate using an android-based motor from a minimum system of ATMEGA 8, 5V Power Supply, blue-tooth, relay, handphone, LCD. Each component is interrelated and connected to form a whole set of tools opening and closing automatic gates using an Android hard-ware based hard-ware. Based on the experimental results the following conclusions can be drawn: (1) Bluetooth can work with a speed of 2.4 GHz and within 10 meters, (2) The speed of the blue-tooth application on the device is 0.1 s and (3) Relay is used as much as 4 to control 4 commands i.e. the first door is open and closed and the second door is open and closed.
The Disclosure of Sharia Non-Compliance Income: Comparative Study between Full-fledged and Subsidiaries Malaysian Islamic Banks
Authors: Puneri Atharyanshah , Chora Moustapha , Ilhamiddin Nazarov , Benraheem Hafiz
Published: May 2020

The purpose of this paper is to analyze to what extend Islamic banks in Malaysia practice disclosure regarding Sharia non-compliant income. Furthermore, this paper also investigates how bank distribute the Sharia non-compliant income. This paper acquires qualitative approach. The qualitative approach is adopted by doinga document analysisabout the literatures from previous studies that the Sharia non-compliant income.Based on the data collected, Bank Islam clearly and properly discloses its Sharia non-compliance income and we recommend any other Islamic banks to follow it. Also, the study find out that does not matter whether they are full-fledge or subsidiaries, the practice is quite the same.
Meningkatkan Hasil Belajar Matematika Materi Penjumlahan Pecahan Penyebut Berbeda Melalui Model Pembelajaran Kooperatif Tipe STAD (Student Teams Achievement Divisions ) Pada Kelas Vb MIN 3 Bantul
Authors: Atmi Suwi
Published: May 2020

Learning using the STAD model is motivated by the low activity and student learning outcomes in mathematics with the subject of the addition of the fraction of the denominator of Bebeda in class VB MIN 3 Bantul. This is the cause because teachers do not use methods that activate students so students can participate in the learning process. Therefore learning is carried out using the STAD model. The class action using the STAD type cooperative learning model is carried out in 2 cycles.

               Learning using the STAD model aims to obtain data to determine the effectiveness of the type of STAD cooperative learning model in improving learning achievement and student learning activeness in learning mathematics. Learning using the STAD model is carried out in 2 cycles. Each cycle consists of 2 meetings. The subject of learning using the STAD model is students in class VB MIN 3 Bantul consisting of 10 male students and 7 female students. Learning using the STAD model was carried out in the first semester of the 2018/2019 school year between August and September 2018. The data collection technique used observation sheets and test sheets during action and implementation.

               The learning outcomes using the STAD model in the first cycle show that the activity and learning achievement increase is still small in scale. Out of 17 students, 11 students completed their studies and 6 students did not complete their studies. In the second cycle learning achievement increased significantly, from 17 students 17 students completed study. Based on the findings, data analysis and data processing obtained from the evaluation evaluation of each cycle in learning using this STAD model, it can be used as a reference regarding the use of STAD type cooperative learning models in the learning process can improve student learning outcomes in learning Addition of Denominators to Verbal Classes in class VB MIN 3 Bantul.

 

Keywords: activeness, learning achievement, STAD type cooperative learning
Pengaruh Living Values Education Program (LVEP) terhadap Penanaman Anti-radikalisme Siswa SD dalam Pembelajaran Tematik
Authors: Apriani An-Nisa
Published: May 2020

Penelitian ini bertujuan untuk mengetahui pengaruh LVEP terhadap penanaman paham anti-radikalisme siswa SD kelas II dalam pembelajaran tematik. Jenis penelitian ini adalah quasi experiment dengan desain pretest-posttest control group design. Populasi dalam penelitian ini adalah seluruh siswa Kelas II SD yang terdiri dari lima kelas.  Sampel terdiri dari dua kelas diambil dari kelima kelas tersebut untuk diberi perlakuan dengan menggunakan metode LVEP dan konvesional. Pemilihan sampel dilakukan secara acak dengan memperhatikan karakteristik siswa yang heterogen berdasarkan hasil wawancara dan observasi peneliti dalam pembelajaran tematik. Kelompok kontrol diberi perlakuan dengan pembelajaran konvensional, sedangkan kelompok eksperimen diberi perlakuan dengan menggunakan LVEP. Teknik pengumpulan data yang digunakan adalah observasi dan wawancara. Sedangkan teknik analisis data yang digunakan adalah uji-t dengan taraf signifikansi 0,05.

Hasil penelitian menunjukkan bahwa ada perbedaaan yang signifikan antara penanaman paham anti-radikalisme dengan LVEP dan pembelajaran konvensional. Perbedaaan tersebut terlihat di semua subkarakter anti-radikalisme yang mencakup nilai citizenship dengan hasil uji-t 0,065, nilai compassion dengan hasil uji-t 0,434, nilai courtesy dengan hasil uji-t 0,700, nilai fairness dengan hasil uji-t 0,504, nilai moderation dengan hasil uji t 1,000, nilai respect for other dengan hasil uji-t 0,826, nilai respect for creator dengan hasil uji-t 0,507, nilai self control  dengan hasil uji-t 0,303, dan nilai tolerance dengan hasil uji t 0,676.

Kata Kunci: LVEP, anti-radikalisme, pembelajaran tematik
Implementasi ASCO (Analyzing, Solving Problems, ans Comparing) terhadap Pembelajaran Membaca Kritis
Authors: Hariyati Nuria Reny
Published: May 2020

Abstract

Research on overcoming exposure to radical issues with critical thinking on critical reading learning is still rarely done. This research is important to be carried out in the reading of the story to avoid radical issues that have been entered in university by using the Asco method (Analyzing, Solving Problems, Comparing). This research approach uses the Quasi-Times Design Series with Control Group experiment. The research data collection, namely the initial test scores and final tests. The experimental group was B2-18 and the control group was B3-18. Data analysis of this study used the One Way Anova SPSS test for Windows with a significance level of <0.05. The results of this study, namely (1) A homogeneous group test of 0.049 which was declared valid because> 0.05 to test this relationship; (2) Anova test of the two groups of 0,000 was declared significant because <0.05. The results showed that there was a significant influence of Asco (Analyzing, Solving Problems, Comparing) on critical reading learning.

 
Keywords: Asco (Analyzing, Solving Problems, Comparing), Implementation, Critical   ReadingLearning 