bluuebunny/crossref_metadata_2025 huggingface dataset:
138-OR: Pioglitazone Amplifies the Decrease in HbA1c and Prevents the Increase in Plasma Ketone Caused by Dapagliflozin in Type 1 Diabetes Mellitus Patients
Authors: ABDUL-GHANI MUHAMMAD , BASKOY GOZDE , NAKHLEH AFIF , ABDELGANI SIHAM , AL-MULLA FAHD , ABU-FARHA MOHAMED , ALAJMI FAHAD , ALESSA THAMER , DEFRONZO RALPH A. , SHEHADEH NAIM
Published: July 2024

Introduction and Objectives: SGLT2 inhibitors (SGLT2i) lower the plasma glucose concentration in T1DM patients. However, they cause an increase in plasma ketone concentration and risk of ketoacidosis. The aim of the present study is to examine whether pioglitazone amplifies the decrease in HbA1c and prevents the increase in plasma ketone concentration caused by dapagliflozin in T1DM patients.

Methods: After a 4-week run in period, 60 T1DM patients received dapagliflozin 10 mg for 12 weeks. At week 16 patients were randomized to receive in double blind fashion pioglitazone (45 mg) or matching placebo for an additional 16 weeks.

Results: T1DM patients were 42±3 years of age, 30% female, BMI=26.8±0.7, HbA1c=8.5±0.2%, insulin dose= 63±4 units, and eGFR=114±6 ml/min. Dapagliflozin caused -0.63±0.18%, and -0.56±0.11% decrease from baseline in HbA1c at week 16 in subjects receiving pioglitazone and placebo, respectively (both p<0.001). At week 32, the decrease from baseline in HbA1c was -0.86±0.3 and -0.44±0.17 in subjects receiving pioglitazone and placebo, respectively. Thus, the HbA1c was -0.42±0.12 lower in subjects receiving pioglitazone versus placebo (p<0.05). Plasma ketone concentration increased above baseline by 0.12±0.03 mM and 0.14±0.03 mM at week 16 in subjects receiving pioglitazone and placebo, respectively (both p<0.05). At week 32 plasma ketone concentration remained elevated above baseline in subjects receiving placebo (0.15±0.03 mM, p<0.05), and decreased below baseline (-0.06±0.02mM, p<0.05) in subjects receiving pioglitazone. Thus, the difference in plasma ketone concentration between subjects receiving pioglitazone and placebo at week 32 was -0.19±0.3, p<0.001.

Conclusion: Addition of pioglitazone to SGLT2i in T1DM patients amplifies the decrease in HbA1c and prevents the increase in plasma ketone caused by SGLT2i, allowing long-term cardiovascular and renal outcome studies to be carried out safely in T1DM patients.

Disclosure

M. Abdul-Ghani: None. G. Baskoy: None. A. Nakhleh: None. S. Abdelgani: None. F. Al-Mulla: None. M. Abu-farha: None. F. Alajmi: Consultant; Novo Nordisk. Research Support; Novo Nordisk. Speaker's Bureau; Novo Nordisk. T. Alessa: None. R.A. DeFronzo: Advisory Panel; AstraZeneca, Novo Nordisk, Boehringer-Ingelheim, Intarcia Therapeutics, Inc., Aardvark, Renalytix, Corcept Therapeutics, Alnylam Pharmaceuticals, Inc. Research Support; Boehringer-Ingelheim, AstraZeneca, 89bio, Inc., Amgen Inc., Medality, Corcept Therapeutics. Speaker's Bureau; AstraZeneca, Corcept Therapeutics, Renalytix. N. Shehadeh: Research Support; Abbott. Advisory Panel; AstraZeneca, Eli Lilly and Company, Boehringer-Ingelheim. Research Support; Novo Nordisk Foundation.

Funding

The study was funded by JDRF grant to MAG. Astrazeneca provided dapagliflozin.
229-OR: Orforglipron Improves Markers of Beta-Cell Function and Insulin Sensitivity in Type 2 Diabetes
Authors: ROSENSTOCK JULIO , ROBINS DEBORAH A. , DUFFIN KEVIN L. , WILSON JONATHAN M. , MATHER KIEREN J. , BANERJEE HIYA , LIN YANZHU , EYDE SARAH , KAZDA CHRISTOF M. , KONIG MANIGE
Published: July 2024

Orforglipron (OFG), an oral, non-peptide GLP-1 receptor agonist, demonstrated significantly greater glycemic control and weight loss at doses ≥12 mg vs placebo (PBO) or dulaglutide (DU) 1.5 mg in a 26-week phase 2 study of adults with type 2 diabetes (T2D) (Table). These exploratory analyses investigated mechanisms by which OFG improved glycemic control in T2D by analyzing exploratory biomarkers.

Participants with T2D (mean age, 58.9 years; baseline HbA1c, 8.1%; weight, 100.3 kg) treated with diet and exercise, with/without metformin, were randomized to PBO, DU 1.5 mg, or once-daily OFG 3, 12, 24, 36, or 45 mg. Biomarkers of β-cell function and insulin sensitivity were analyzed by mixed model repeated measures, excluding data after study drug discontinuation or rescue drug initiation.

Biomarkers of β-cell function were improved by OFG at 26 weeks from baseline (Table). HOMA-B significantly increased with OFG at doses ≥12 mg vs PBO or DU. HOMA-IR (computed with insulin) significantly decreased from baseline with OFG at doses ≥24 mg but was not significantly different vs PBO and DU. Fasting glucose-adjusted glucagon significantly decreased with OFG at doses ≥12 mg vs PBO and with OFG 12, 24, and 45 mg vs DU.

These analyses suggest improved glycemic control with OFG vs DU may be partly explained by improved β-cell function and insulin sensitivity. Additional studies are ongoing to understand these mechanisms.

Disclosure

J. Rosenstock: Research Support; Biomea Fusion, Inc. Other Relationship; Lilly Diabetes. Research Support; Merck & Co., Inc., Novartis Pharmaceuticals Corporation, Corcept Therapeutics. Other Relationship; Novo Nordisk. Research Support; Pfizer Inc. Other Relationship; Sanofi, Boehringer-Ingelheim. Research Support; Shionogi & Co., Ltd. Other Relationship; Structure Therapeutics, Inc. Advisory Panel; Terns Pharmaceuticals, Zealand Pharma A/S. Other Relationship; Applied Therapeutics, Hanmi Pharm. Co., Ltd., Oramed Pharmaceuticals. Advisory Panel; Scholar Rock. D.A. Robins: None. K.L. Duffin: Employee; Eli Lilly and Company. J.M. Wilson: Employee; Eli Lilly and Company. K.J. Mather: Employee; Eli Lilly and Company. H. Banerjee: None. Y. Lin: Stock/Shareholder; Eli Lilly and Company, Pfizer Inc., AstraZeneca. S. Eyde: None. C.M. Kazda: Employee; Eli Lilly and Company. M. Konig: None.

Funding

Eli Lilly and Company
344-OR: The MOTS-c/CK2 Pathway Is a Novel Molecular Target for Type 2 Diabetes in East Asians
Authors: KUMAGAI HIROSHI , JEONG KIM SU , MILLER BRENDAN , HYUNG LEE SHIN , ZEMPO HIROFUMI , NATSUME TOSHIHARU , WAN JUNXIANG , RAMIREZ RICARDO , MEHTA HEMAL H. , NISHIDA YUICHIRO , FUKU NORIYUKI , DOBASHI SHOHEI , MIYAMOTO-MIKAMI ERI , NAITO HISASHI , HARA MEGUMI , IWASAKA CHIHARU , YAMADA YOSUKE , HIGAKI YASUKI , TANAKA KEITARO , YEN KELVIN , COHEN PINCHAS
Published: July 2024

Introduction & Objective: MOTS-c is a mitochondrial DNA-encoded microprotein that improves impaired glucose metabolism caused by aging and high fat diet. The presence of a naturally occurring genetic variant of MOTS-c, K14Q MOTS-c, increases the susceptibility to type 2 diabetes (T2D) in East Asians. Nevertheless, the precise mechanism of MOTS-c action has not been fully elucidated. Here, we demonstrate that the protein kinase CK2 is a functional and direct target of MOTS-c and that the reduced binding of K14Q MOTS-c to CK2 increases the risk of T2D.

Methods: We performed in vitro experiments, including dot blot, kinase activity, and surface plasmon resonance assays, to investigate the direct interaction between MOTS-c and CK2. We also examined the impact of MOTS-c treatment on CK2 activity in skeletal muscle, as well as on muscle glucose uptake in young mice. Subsequently, we investigated the impact of a naturally occurring K14Q MOTS-c variant on the prevalence of T2D in 12,068 Japanese individuals.

Results: Dot blot and cell-free kinase activity assays demonstrated that MOTS-c activated CK2 by binding directly to its α subunit, and this binding was confirmed using a surface plasmon resonance assay. Importantly, the binding affinity of K14Q MOTS-c to CK2α was 16-fold less than that of the wild type MOTS-c, and K14Q MOTS-c did not activate CK2 in the cell-free kinase activity assay. Skeletal muscle CK2 activity was lower in old mice and higher after exercise, and was increased by MOTS-c administration, but not K14Q MOTS-c. MOTS-c administration, but not K14Q MOTS-c, significantly enhanced muscle glucose uptake, which was blunted by a CK2 inhibitor. In humans, the K14Q MOTS-c carriers exhibited an increased risk of type 2 diabetes, particularly among individuals aged 60 and above, while this increased risk was mitigated by daily physical activity.

Conclusion: Together, these findings provide evidence that CK2 is required for MOTS-c effects and that the MOTS-c/CK2 pathway is a potential therapeutic target for T2D.

Disclosure

H. Kumagai: None. S. Kim: None. B. Miller: None. S. Lee: None. H. Zempo: None. T. Natsume: None. J. Wan: None. R. Ramirez II: None. H.H. Mehta: None. Y. Nishida: None. N. Fuku: None. S. Dobashi: None. E. Miyamoto-Mikami: None. H. Naito: None. M. Hara: None. C. Iwasaka: None. Y. Yamada: None. Y. Higaki: None. K. Tanaka: None. K. Yen: None. P. Cohen: None.
348-OR: Multiancestry Whole Genome Sequencing (WGS) Meta-analysis to Identify Loci Associated with Imaging-Measured Hepatic Steatosis
Authors: ALLRED NICHOLETTE , RAUT CHINMAY , CHEN YANHUA , OLIVERI ANTONINO , O'CONNELL JEFFREY , RYAN KATHLEEN , ROTTER JEROME I. , RICH STEPHEN S. , HAKIM AARON , PEYSER PATRICIA , BIELAK LAWRENCE F. , LIU CHING-TI , TERRY JAMES G. , FORNAGE MYRIAM , WAGENKNECHT LYNNE E. , SPELIOTES ELIZABETH K. , TRANS-OMICS FOR PRECISION MEDICINE (TOPMED)PROGRAM NHLBI , CONSORTIUM GOLD
Published: July 2024

Introduction and Objective: Steatotic liver disease, formerly called non-alcoholic fatty liver disease (NAFLD), is the most common cause of chronic liver disease worldwide; yet, few effective methods for prevention/treatment exist making it one of the biggest unmet public health needs of our time. To date, genetic studies have been limited to identifying common variants in predominantly European-ancestry populations or focused on surrogate phenotypes, e.g. liver enzymes, identifying association with comorbidities. Here we present a multi-ancestry whole genome sequencing (WGS) association study to discover rare variants associated with imaging-measured hepatic steatosis.

Methods: Study-, ancestry- and sex-stratified association analyses were conducted using SAIGEgds in nine studies with imaging-measured hepatic steatosis adjusted for age, sex, alcoholic drinks per week and principal component estimates of admixture. Stratified results were meta-analyzed using a fixed-effects model. Cochran’s Q-test and the I2 metric were used to estimate heterogeneity.

Results: Meta-analyses included 23,156 European, African, Hispanic and Chinese ancestry individuals and identified five significant loci (P<5x10-08): PNPLA3, PPP1R3B, HAPLN4, intergenic region on chr14 and F11-AS1. Nine additional variants trended toward association (P<5x10-07). Sex-stratified meta-analyses revealed additional associations in an intergenic region on chr10, RP11-115J16.1 and UBE3B. Variants in RP11-115J16.1 remained significant in European ancestry samples. Significantly associated variants in SLC2A1-AS1 and LINC01684 were novel loci in African Americans.

Conclusion: Taken together, multi-ancestry analysis of imaging-measured hepatic steatosis using WGS replicated previously associated loci and identified novel sex- and ancestry-specific loci. Functional studies are underway to determine the biological impact of these findings.

Disclosure

N. Allred: None. C. Raut: None. Y. Chen: None. A. Oliveri: None. J. O'Connell: None. K. Ryan: None. J.I. Rotter: None. S.S. Rich: None. A. Hakim: None. P. Peyser: None. L.F. Bielak: None. C. Liu: None. J.G. Terry: None. M. Fornage: None. L.E. Wagenknecht: None. E.K. Speliotes: Other Relationship; University of Michigan.

Funding

National Institute of Diabetes and Digestive Kidney Disease (R01 DK128871)
Sitting Time and Its Interaction With Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes
Authors: Dai Wen , Albrecht Sandra S.
Published: July 2024

OBJECTIVE

To evaluate whether associations between sitting time and all-cause and heart disease mortality are modified by physical activity in adults with diabetes.

RESEARCH DESIGN AND METHODS

Data came from 6,335 U.S. adults with diabetes from National Health and Nutrition Examination Survey 2007–2018 (baseline), with mortality follow-up through 2019. Sitting time and moderate to vigorous physical activity (MVPA) were self-reported. Cox models were adjusted for sociodemographics, lifestyle factors, and medical conditions.

RESULTS

Over a median follow-up of 5.9 years, 1,278 all-cause and 354 heart disease deaths were documented (mean age, 59.6 years; 48.3% female). Longer sitting time was associated with greater all-cause and heart disease mortality risk in inactive (MVPA <10 min/week) or insufficiently active (MVPA 10 to <150 min/week) adults with diabetes, but not in active adults (MVPA ≥150 min/week) (all-cause mortality: P = 0.003 for interaction; heart disease mortality: P = 0.008 for interaction).

CONCLUSIONS

In adults with diabetes, meeting guideline-recommended physical activity may offset the elevated all-cause and heart disease mortality risk associated with excessive sitting time.
The Relationship Between Body Mass Index (BMI) and Balance in Down Syndrome Children at the X Depok Foundation
Authors: Mailani Rena , David Natasya Salima , Faradillah Kiki Rezki , Ismiyasa Suci Wahyu
Published: July 2024

Introduction: In Indonesia, there are more than 300,000 children with Down syndrome. Down syndrome is a chromosomal abnormality that occurs while still in the womb. Children with Down syndrome have a high risk of being overweight or even obese. This increase in BMI causes various problems, one of which is the weakening of strength and loss of balance.Purpose: To determine the relationship between body mass index (BMI) and balance in children with Down syndrome at Yayasan X.Method: This study used a correlational study design with a cross-sectional approach with a sample of 89 children with Down syndrome. This research was conducted offline by using the pediatric balance scale and measuring body mass index (BMI).Result: This study used SPSS 23 and the results obtained p =0,000 on balance with the correlation coefficient between BMI of 0.559 conclusion there is a unidirectional relationship between BMI and balance.Conclusion: There is a relationship between body mass index and balance in the same direction in childrenwith Down syndrome at Yayasan X.
Effectiveness of PTR Home-based Exercise and Education Program in COPD Patients: Systematic Review
Authors: Trisnowiyanto Bambang , Arif Fadli
Published: July 2024

Pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) patients requires time and full adherence to the treatment program. The difficulty of transportation and the patient's economic barriers raise the need for pulmonary telerehabilitation (PTR). The purpose of this study was to summarize existing literature data regarding the effectiveness of PTR home-based exercise and education program in COPD Patients. A systematic review with qualitative descriptive analysis method of the study from the electronic database Pubmed, Willey Online Library, Science Direct, EBSCO, Ovid. There are 6 articles included in this study that stated that the effectiveness of home-based PTR exercise and education programs is comparable to hospital-based PR exercise and education programs in evaluating exercise capacity and quality of life. 5 articles had a dropout rate from participants in the intervention group <20% and 1 article had a dropout rate from participants in the intervention group >20%. 3 articles had a dropout rate from control group participants <20% and 3 articles had a dropout rate from control group participants >20%. Effectiveness of the PTR home-based exercise and education program is comparable to the effectiveness of the hospital-based PR exercise and education program in evaluating exercise capacity and quality of life with the cost efficiency of treatment.
Keywords: effectiveness, PTR, patient’s, COPD.
The Effect of Static Stretch and Static Contraction on Pain and Functional Ability of Knee Pain Sufferers
Authors: Fitri Desi Tri Syawatul , Siwi Ken , Waritsu Cakra , Putri Fadma
Published: July 2024

Background: Knee pain is caused by various things, for example, excessive daily activities, obesity, osteoarthritis, trauma to the knee, age, post-surgery, and the work of housewives who often carry out excessive daily activities by squatting for a long time while washing. dishes and washing clothes, resulting in knee pain and decreased functional ability. Research Method: This research is quantitative research with an experimental design (the one-group pretest-posttest) involving 10 samples of PKK mothers. The research began in May 2023-February 2024, and the intervention was carried out for 2 weeks with an intensity of 6 meetings. There are 2 instruments used, namely the visual analogue scale (VAS) to measure pain and the Jette scale to measure functional ability. Data analysis used SPSS with the Wilcoxon test. Results: Giving a combination of Static Stretch and Static Contraction can significantly reduce pain (p<0.05) and increase the functional ability of knee pain sufferers (p<0.05). Conclusion: There is an effect of the combination of Static Stretch and Static Contraction on reducing pain and increasing the functional ability of knee pain sufferers at PKK Rt 02 Dusun Manggung Sidoarjo.
The Relationship between Physical Activity Levels and Quality of Life in Menopausal Women
Authors: Guna I Wayan Adi Wira , Andayani Ni Luh Nopi , Ayu I Gusti , Putra I Putu Yudi Pramana
Published: July 2024

Physiologically during menopause, women will experience a decrease in the function of the ovaries which causes a decrease in reproductive hormones and increased health problems that have an impact on their quality of life. In general, the quality of life of menopausal women is influenced by several aspects, one of which is the level of physical activity carried out daily. This study aimed to determine the relationship between physical activity level to quality of life in menopausal women. The method used in this research is observational analytics with a cross-sectional approach. The sampling technique used is purposive sampling. The number of samples obtained in this study was 69 samples. Data collection was done by measuring physical activity levels and quality of life. Physical activity levels were measured using the Global Physical Activity Questionnaire (GPAQ) while quality of life was measured by the World Health Organization Quality of Life Questionaire (WHOQOL-BREF). Based on the non-parametric analysis test of Spearman rho, a value of p = 0.000 (p < 0.05) and a correlation coefficient r = 0.649. Based on the results of the study, it can be concluded that there is a significant relationship between the level of physical activity and menopausal women.
Analisis Semiotika Riffaterre dalam Puisi "Hiya Fil Masāi Waḥīdatin” Karya Mahmoud Darwish
Authors: Raden Muhammad Ardiansyah Kurniawan  , Ridwan Ritonga  , Aminuddin Hrp Arpin , Kastrawi Puji , Manan Nasution Abdul , Ismail
Published: July 2024

This study aims to uncover the deepest meaning of language signs in Mahmoud Darwish's Hiya Fil Masāi Waḥīdatin poetry using Micheal Riffaterre's semiotic theory. This research uses a descriptive method with qualitative analysis. The source of this research data is the poerty Hiya Fil Masāi Waḥīdatin which consists of 34 lines. In interpreting signs in poetry, Riffaterre offers two concepts of reading. The first stage is through heuristic reading, then hermeneutic reading, followed by models, variants, matrices, as well as hypograms. The results of this study were found in heuristic readings of the meanings that are still ambiguous and heterogeneous. On the other hand, in hermeneutic reading, the model that is in the form of "sadness" is found in stanzas 1 and 2. These two stanzas represent the entire content of the poem, for the whole stanza reflects a man's sorrow for him (his country). Then the model was developed into variants namely sympathy and struggle. The matrix in this poem describes "the meaning of a homeland". The hypogram of Hiya Fil Masāi Waḥīdatin poetry is backed by two poetries, namely Yaumiyātu Jurḥ Filasṭīnī and Al-Waṭan ‘an Syain which have the meaning of suffering from alienation and longing so that a sense of struggle arises.
Formulation And Evaluation Of Black Glutinous Rice Clay Mask (Oryza sativa L. Var Glutinosa) Using Bentonite And Kaolin Variations
Authors: Fiskia Ermalyanti , Nur Amran , Cindhany Darmaria Faridha Utami Mala
Published: July 2024

Black glutinous rice is a staple cuisine consumed frequently by Indonesians. Black glutinous rice's high anthocyanin content can stimulate collagen production. This study seeks to determine the effects of the kaolin and bentonite combination on different concentrations as a clay mask and obtain the optimal composition formula. Optimizing the clay mask formula using the factorial design procedure. The evaluation of a formula includes organoleptic, homogeneity, pH, irritation, and drying time tests. The research findings indicated that all preparations satisfied the evaluation criteria before the pH test. The results showed that kaolin can elevate the pH level, while bentonite can lower the pH. Preparations F1 and F2 satisfy the requirements, whereas F3 fails to fulfil the standards following the pH test. F1 (5 % bentonite and 15 % kaolin) and F2 (3 % bentonite and 25 % kaolin) were optimal clay mask formulas for black glutinous rice.
Program Pengabdian Masyarakat Internasional di Sekolah Bersepadu Musa-Asiah (Sepama) Cambodia: Pembelajaran Bahasa Indonesia Menggunakan Arab Pegon
Authors: Febriandika Nur Rizqi , Imron Rosyadi  , Yayuli
Published: July 2024

Kamboja merupakan suatu negara yang masih dalam area Asia Tenggara dan berbentuk kesatuandengan penduduknya secara mayoritas berkeyakinan agama budha (97%). Walaupun demikiandi bagian wilayah kamboja yakni daerah cham mayoritas beragama Islam dengan corak budayamelayu. Di Champ berdiri lembaga-lembaga pendidikan yang berbasis kepada keislamaanyang digunakan masyarakat Muslim Kamboja Khususnya dari ras melayu mendidik anakanaknyaatau generasi sebagai penerus perjuangan Islam masihlah sedikit. Tidak jarang jugamasyarakat kamboja mengirimkan anak-anaknya untuk menempuh pendidikan di Indonesiayang notabenya sebagai Negara Islam yang lebih maju. Walaupun demikian jumlah maysrakatMuslim yang bisa berbahasa Indonesia atau melayu masihlah sedikit dan minim mengingatmereka juga banyak tertarik melanjutkan studi di perguruan tinggi Muhammadiyah di Indonesia.Walaupun demikian mereka mengalami kesulitan dalam belajar bahasa asing yang notabenenyamenggunakan huruf alfabet sebab bahasa kamboja memiliki huruf sendiri yang berbeda denganhuruf alfabet. Oleh sebab itu kami akan melaksanakan pengabdian masyarakat selama 6 bulandi Sekolah Bersepadu Musa-Asiah (SEPAMA) Cambodia yang merupakan satu-satunya sekolahmuslim swasta yang dikelola oleh Yayasan Musa-Asiah Fondation. Pengabdiana masyarakat ini dalam bentuk pendampingan pembelajaran bahasa Indonesia menggunakan arab pegon karenadinilai lebih efektif dalam mengajarkan bahasa indonesia sebab sebagai seorang muslim merekasudah dibekali pembelajaran aksara arab sebelum masuk sekolah dasar. Tim pengabdian akanbekerjasama dengan pihak sekolah dalam merumuskan pembelajaran arab pegon yang sesuaidengan jenjang pendidikan. Setelah itu, mahasiswa akan diterjunkan di kamboja selama 6 bulansebagai penutur asing guna mengajarkan dan mencontohkan pembelajaran arab pegon.
Pendampingan Rumah Ibadah (Gereja dan Pura) pada Penyusunan Laporan Keuangan di Kabupaten Sorong
Authors: Sarah Kabes Yulce Jubelin , Khotimah Nurul , Firdaus Adnan , Tumana Ristan Jonmer , Munzir
Published: July 2024

Laporan keuangan merupakan pertanggungjawaban suatu entitas melalui penyajian struktur posisi keuangan yang bertujuan untuk menunjukkan kinerja entitas pada suatu periode tertentu. Penyusunan laporan keuangan merupakan hal yang penting bagi suatu entitas atau organisasi, baik yang bersifat nirlaba maupun suatu entitas dengan tujuan mencari keuntungan atau keuntungan. FKUB Kabupaten Sorong yang merupakan mitra pelayanan memberikan informasi bahwa ditemukan kondisi rumah ibadah di Kabupaten Sorong yang belum melakukan pencatatan laporan keuangan sesuai standar dan melakukan pembukuan dengan menggunakan pencatatan manual. Penemuan inilah yang menjadi awal di lapangan sehingga diperlukan pendampingan bagi mitra. Metode pelaksanaan pengabdian berupa kegiatan workshop atau pendampingan secara langsung kepada mitra dan Masyarakat mitra dengan menganalisis menggunakan pree-test dan post-test. Adapun peserta berasal dari pengurus gereja 10 orang, pengurus pura 10 dan mitra FKUB 5 Orang. Kegiatan lokasi pendampingan dilakukan pada Gereja dan Pura yang berada di Distrik Salawati Kabupaten Sorong. Berdasarkan hasil analisis yang dilakukan dapat disimpulkan bahwa pelaksanaan pengabdian menunjukkan adanya peningkatan pengetahuan dalam menyusun laporan keuangan rumah ibadah sebelum dan sesudah dilaksanakannya pendampingan. Hasil persentase diperoleh setelah dilaksanakannya pendampingan meningkat dari 54,34% menjadi 92,50% dari total peserta sebanyak 25 orang.
Peningkatan Kompetensi Guru PAI dalam Menerapan Metode Pembelajaran Aktif pada Proses Pembelajaran Guna Meningkatkan Motivasi Belajar Siswa di Pesantren Muhammadiyah Se-Kabupaten Boyolali
Authors: Ibnu Rushd Dartim , Mohamad Ali  , Nurul Latifatul Inayati  , Muh. Nur Rochim Maksum  , Mahasri Shobahiya
Published: July 2024

Metode pembelajaran aktif atau Active Learning adalah urutan kegiatan proses pembelajaran yang sistematik dan berfokus terhadap keaktifan siswa, di mana guru memiliki posisi sebagai fasilitator yang membuat suasana belajar menjadi lebih ideal dan menghidupkan suasana agar peserta didik menjadi aktif. Pembelajaran aktif berprinsip bahwa yang belajar adalah siswa. Maka tugas guru adalah membantu siswa belajar dengan baik. Kurangnya tenaga pendidik yang ahli dalam metode pembelajaran aktif menjadi permasalahan tersendiri bagi kalangan akademisi. Terutama di lingkungan pondok pesatren yang menyebabkan siswa kurang termotivasi dalam belajar. Kenyataannya di dalam proses pembelajaran, baik di dalam pembelajaran nasional maupun pembelajaran yang bersifat agama cenderung banyak terpusat pada strategi pembelajaran klasik yang kurang adanya interaksi antara guru dan siswa. Di mana siswa hanya lebih banyak pasif sebagai pendengar.
Maka penulis memberikan solusi sebagai bentuk kegiatan pengabdian: pertama, melakukan pelatihan dan sosialisasi berupa Workshop kepada para guru dan staff kependidikan Pesantren Muhammadiyah se-Boyolali mengenai strategi pembelajaran aktif. Solusi tersebut diharapkan mampu memberikan bekal pengetahuan dan skill mengenai pembelajaran aktif dan dapat diaplikasikan dalam proses pembelajaran sehingga dapat lebih maksimal dan berdampak pada semangat belajar siswa yang meningkat. Kedua, di sisi lain di saat yang sama melakukan pendampingan kepada para guru ketika menerapkan strategi pembelajaran aktif ketika mengajar siswa, harapannya ada feedback dan evaluasi terhadap strategi pembelajaran aktif yang sudah dilakukan sehingga dapat dilakukan perbaikan-perbaikan yang dapat menjadikan lebih baik lagi dalam proses pembelajaran menggunakan strategi pembelajaran aktif.
Surrealismo ao New Queer Cinema
Authors: Cardoso Alexandre
Published: July 2024

Estendendo-se da literatura à fotografia e às artes plásticas e, mais tardiamente, ao cinema, o surrealismo revolucionou de maneira impressionante a linguagem clássica das artes. De fato, como se sabe, desde os alvores do século passado, o movimento introduziu seus singulares métodos de montagem e sua filosofia própria nas estruturas narrativas desses diferentes domínios estéticos, em honra do reconhecimento das manifestações do inconsciente. Diante disso, o objetivo do presente artigo é não apenas reapresentar o movimento, em sua conexão com a psicanálise, mas valer-se da própria revolução psicanalítica, com sua teorização da ambiguidade sexual,  para  examinar a questão dos gêneros e das posições sexuais no seio de uma cinematografia de risco mas não obstante marcada pela assinatura masculina e pela cisheteronormatividade.
Objects of Legal Relationships: Sector-Specific Approach
Authors: Ivanova S. V.
Published: July 2024

Introduction. The object of legal relationship is an important element of any legal relations. This is due to the fact that no legal relationship can take place if there is no an object. In the doctrine of law, the essence of an object of legal relationship is under dispute. As a result of doctrinal research, the monistic and pluralistic concepts have been formulated in the legal literature. The aim of this article is to study the theoretical provisions for the object of legal relationship and develop practical recommendations on amending the current legislation. Based on the provisions of the object of legal relationship concepts existing in the doctrine of law, the author investigates the specific features of the legal relationship objects of the animal world protection and use. Nowadays the study of the objects of faunistic legal relationships is relevant due to importance of the animal world objects for the society and state, because in the process of rights and liabilities fulfilment, the subjects of legal relationships satisfy the economic, environmental and social interests.

Materials and Methods. In the article, the methodological basis is formed by a set of philosophical, general scientific and specific scientific methods of cognition (analysis, synthesis, concrete-historical, logical methods, etc.).

The Results. Formulating the practical recommendations for amending the current animal welfare legislation is claimed to be the research result. The article differentiates the regulation of the faunistic and civil legal relationships.

Discussion and Conclusion. The article could be used in the educational activities of law universities and faculties, as well as in the activities of the executive authorities of the Russian Federation subjects. The author has provided the definition of a juridical and material objects of faunistic legal relationship and examined the differences and features thereof. To fill in the gaps in legislation, the author has proposed to develop and adopt the regulatory legal acts within the jurisdiction of the subjects of the Russian Federation aimed at regulating the relationships on the use of the wild animals not classified as hunting and fishing resources. The author has drawn the conclusion on the necessity to include CITES species and derivatives into the current animal welfare legislation. The theoretical and practical conclusions made by the author could be taken into account for further study of the specifics of the faunistic legal relationship.
Cytological Grading of Breast Carcinoma and Its Correlation with Histological Grading
Authors: Khadka Dinesh , Karki Smriti , Agrawal Meenu , Agrawal Rajat
Published: July 2024

Background. Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women. Since the easiest way of diagnosing breast carcinoma is Fine Needle Aspiration Cytology (FNAC), it is important to perform grading of the malignancy on aspirates obtained as it will provide valuable information for further management. Materials and Methods. It is a hospital-based prospective study conducted in the Department of Pathology (Cytopathology and Histopathology) at B.P. Koirala Institute of Health Sciences, Dharan, Nepal for one year, including forty-five (45) cases. Results. ost patients were in the age group 41–50 years. The most common type of carcinoma detected was an Infiltrating ductal carcinoma followed by Infiltrating lobular carcinoma. The correlation between cytopathology and histopathology findings was evaluated by utilizing the Simplified Black grading Modified Black grading, Hunt’s grading, and Nottingham Modification of Scarff-Bloom-Richardson grading system all of then showed more than 80% concordance rate. Conclusion. Grading of breast malignancy obtained from Fine Needle Aspiration Cytology smears is easy to perform and has a high concordance rate with histological grading.
Islamic Media Coverage Strategies in Post-Pandemic Hajj Reporting
Authors: Setiadi Anggi Arif Fudin , Ningsih Ida Nuraini Dewi Kodrat , Prastya Narayana Mahendra Prastya
Published: July 2024

The Hajj worship in 2022 is the first post-pandemic time for journalists outside Saudi Arabia to report on the Hajj process. This research discusses Islamic media's coverage strategy, which assigns journalists to Saudi Arabia to cover the Hajj. The research utilized a qualitative method with data sources based on interviews with journalists from Republika media, tv Muhammadiyah (tvMu), and NU Online. The research findings reveal that Indonesian journalists can merely cover the Hajj Media Centre of the Indonesian Ministry of Religious Affairs. Another limitation is the prohibition of Saudi Arabian authorities from taking pictures with professional cameras, so journalists employ smartphones to take photos and videos. Regarding news themes, Republika highlighted the importance of health protocols for Indonesian pilgrims. At the same time, NU Online and tvMu reported on religious principles addresed to their respective organizations' perspectives. Primary news sources included pilgrimage officers in Saudi Arabia and Indonesian authorities. In particular, tvMu and NU Online correspondingly interviewed news sources from their respective organizations.
New Zealand’s Coalition Government Gang Policy and the Death of Evidence
Authors: Tauri Juan Marcellus
Published: July 2024

A particular focus of the NZ government in relation to crime control is its stated aim to ‘smash the gangs’, signalled through a range of policies, including banning gang patches and providing police with enhanced dispersal powers. So far, one significant feature of the government's platform is its inability to provide evidence that demonstrates the efficacy of the criminal justice policies and interventions it plans to implement, such as boot camps and banning patches. Government members have also shown themselves immune to evidence of the efficacy of existing policies and interventions it has sought to remove, or that problematises their claims about the likely success of those they want to introduce. It is argued that the government is employing an ideology-based policy process that is driven by political expediency (winning votes) rather than employing an evidence-based approach, which would demonstrate a genuine concern for reducing crime and ‘making us safer’.
Unele considerații privind impactul deciziei Curții Constituționale a României nr. 176 din 24 martie 2022 asupra măsurii confiscării speciale a unor produse de tutun accizabile provenite din contrabandă
Authors: Coadă Ciprian
Published: July 2024

Adoptarea de către Curtea Constituțională a României a Deciziei nr.176 din 24 martie 2022, publicată în Monitorul Oficial al României nr.451 din 05.05.2022, a dat naștere unor vii discuții, cu privire la modalitatea de interpretare și efectelor acesteia, în raport de conținutul dispozițiilor art.4 - art.5 Cod penal și art.3 din Legea nr.187/2012, privind aplicarea legii penale de dezincriminare și a legii penale mai favorabile în cauzele penale aflate în curs și cele definitiv soluționate. O problemă apărută în practica instanțelor, dar mai puțin reflectată în literatura de specialitate, privește posibilitatea instanței de judecată de a dispune confiscarea specială a unor bunuri provenite din infracțiunea de contrabandă asimilată, potrivit art.112 alin.1 lit. f Cod penal, în cauzele finalizate cu o soluție de achitare, întemeiată pe dispozițiile art.16 alin.1 lit. b teza I Cod procedură penală și efectele Deciziei Curții Constituționale nr.176/2022. Dificultatea acestei probleme derivă din faptul că deși dispozițiile art.4 Cod penal impun judecătorului o soluție de înlăturare a efectelor confiscării în caz de dezincriminare a faptei, dispozițiile Regulamentului vamal al Uniunii Europene impun statelor membre soluții menite să protejeze Uniunea de comerțul inechitabil și ilegal, care să încurajeze activitățile economice legitime, stabilind în sarcina fiecărui stat obligația de a institui sancțiuni efective, proporționate și cu efect de descurajare, în caz de încălcare a legislației vamale unionale. Prioritatea dreptului unional îndeamnă, într-o astfel de situație, la identificarea unei soluții care să asigure eficiența și efectivitatea Regulamentului vamal al Uniunii Europene, așa încât, prin intermediul acestui studiu, vom încerca să demonstrăm, pe baza unor argumente de interpretare regăsite și în jurisprudența națională recentă, că măsura de siguranță a confiscării unor bunuri provenite din contrabandă poate fi aplicată nu doar în procedura contravențională subsecventă celei penale, ci și într-o cauză penală în curs, finalizată cu achitarea inculpatului.
Paparan PM10 dan PM2,5 Pada Pekerja Industri Phinisi di Kecamatan Bonto Bahari Kabupaten Bulukumba
Authors: Wahab Wahyudi , Saleh Muhammad , Amansyah Munawir , Susilawaty Andi , Basri Syahrul
Published: July 2024

Particulat Matter (PM10) merupakan debu yang memiliki ukuran 0,25-10 mm dan Particulate Matter 2,5 adalah partikel dengan diameter aerodinamik lebih kecil dari 2,5 µm yang dengan mudahnya masuk ke saluran pernafasan melalui hidung hingga alveoli yang menyebabkan ganguan keluhan subjektif Infeksi Saluran Pernafasan Akut (ISPA) selain kadar debu, karakteristik pekerja juga berpengaruh terhadap keluhan-keluhan yang dialami pekerja. Tujuan penelitian ini untuk mengetahui kadar konsentrasi PM10 dan PM2,5 pada limbah serbuk kayu terhadap keluhan ISPA pada pekerja industri phinisi, Kec Bontobahari, Kab Bulukumba. Untuk mengetahui kadar konsentrasi PM10 dan PM2,5 pada limbah serbuk kayu terhadap keluhan ISPA pada pekerja industri phinisi di Kecamatan Bonto Bahari Kabupaten Bulukumba. Penelitian ini adalah penelitian kuantitatif menggunakan pendekatan Deskriptif. Populasi dalam penelitian ini adalah pekerja perahu phinisi di Kecamatan Bontobahari Kabupaten Bulukumba sebanyak 70 responden dengan menggunakan teknik pendekatan purposive sampling dan teknik analisis data yakni uji statistik chi-square. Dari hasil penelitian di dapatkan kadar di Pantai Mandala menghasilkan rata-rata 9,18 g/m3  untuk PM10 dan 0,94 g/m3 untuk PM2,5, di Pantai Bira dengan rata-rata PM10 4,02 g/m3  dan <0,1 g/m3 PM2,5 , dan Tanah Lemo dengan rata-rata 10,2 g/m3  dan 0,91 g/m3 untuk PM2,5 dimana kadar PM di lokasi tersebut tidak melebihi nilai ambang batas. Bagi pekerja di area industri phinisi agar senantiasa menggunakan masker disetiap bekerja untuk mengurangi risiko karena dengan menggunakan masker keluhan gangguan pernafasan kemungkinan bisa berkurang.
 
Kata Kunci : Kadar PM10,Kadar PM2,5 , Industri Phinisi
Unveiling the Presence of Escherichia coli in Meatball Cart Traders' Tableware: A Comprehensive Analysis in Region X
Authors: Dwi Yunatiasri Listy , Yudha Redi
Published: July 2024

Pedagang bakso gerobak keliling merupakan pedagang kaki lima dengan menggunakan gerobak yang dibawa oleh pedagang bakso dan berpindah-pindah, fasilitas makanan yang dimuat dalam gerobak memungkinkan tingkat sanitasi yang buruk diakibatkan oleh keterbatasan tempat dan kebersihan peralatan makan yang buruk mempunyai peranan penting dalam pertumbuhan penyebaran kuman penyakit oleh bakteri khususnya E.coli. Tujuan penelitian ini untuk mengetahui keberadaan Escherichia coli pada mangkuk yang digunakan pedagang bakso gerobak, mengetahui sarana (alat) dan sanitasi lingkungan, mengetahui tingkat pengetahuan, sikap, dan perilaku pedagang terhadap teknik pencucian, pengeringan, dan penyimpanan alat makan. Jenis penelitian ini bersifat deskriptif dengan analisa laboratorium untuk mengetahui keberadaan Escherichia coli pada mangkuk. Teknik sampel menggunakan total sampling dengan jumlah populasi 10 pedagang. Hasil pemeriksaan dari sepuluh sampel mangkuk 100% memenuhi syarat dengan standar baku mutu keberadaan Escheriscia coli sesuai Peraturan Menteri Kesehatan Republik Indonesia No. 1096/Menkes/Per/VI/2011 yaitu 0 (Nol) atau <1x101 CFU/cm2. Hasil observasi terkait peralatan 60% memenuhi syarat dan sanitasi tempat berjualan 80% memenuhi syarat. Perilaku pedagang bakso terhadap teknik pencucian, pengeringan dan penyimpanan dikategorikan cukup dengan rata-rata 65,45%. Penilaian sikap pedagang dikategorikan baik dengan nilai rata-rata 75,8%, dan perilaku pedagang dikategorikan cukup 65,4545%. Disarankan untuk selalu menjaga kebersihan terutama alat makan dan lingkungan berjualan.
Limbah Pelepah Batang Pisang dan Rak Telur Sebagai Inovasi K3 dalam Meredam Kebisingan
Authors: Alimus Nur Aqidatul Izzah , Mallapiang Fatmawaty , Haerana Bs. Titi , Jusriani Rini
Published: July 2024

Noise is unwanted sound and is a source of environmental pollution, especially the work environment. Some of the impacts of noise on health include communication disorders, decreased concentration, and temporary or permanent deafness. One of the alternatives in reducing noise is the use of waste banana stems and egg racks. The purpose of this study was to determine the effectivity of banana stems and egg racks as noise silencer. This type of research is a pure experimental research using a pretest and posttest design with a control group. Noise simulation of 93 dB was given to the control group and the treatment (intervention) group. Furthermore, the intervention group was given banana stem and egg rack noise dampening materials with a composition of 50%: 50%, thickness of 3 cm and 5 cm, and was not given any treatment to the control group. Results showed that the noise dampening material from banana stem fronds and egg racks with a composition of 50% : 50% with a thickness of 3 cm and 5 cm was able to reduce noise. The thicker the material, the greater the intensity of the muted noise. Conclusion: Banana stem waste and egg racks effective as noise silencer.
 
Keywords: waste, banana stem fronds, egg racks, noise, OHS
KEMAMPUAN PEMECAHAN MASALAH MENGGUNAKAN BAHAN AJAR SISTEM PERSAMAAN LINEAR (SPL)
Authors: Sarassanti Yumi , Permatasari Rindah
Published: July 2024

Penelitian dilakukan dengan tujuan untuk menganalisis kemampuan siswa dalam memecahkan permasalahan menggunakan bahan ajar sistem persamaan linear di SMK Bina Sabjanoba. Metode dalam penelitian ini Peneliti menggunakan jenis penelitian kualitatif dengan pendekatan deskriptif. Subjek dalam penelitian ini merupakan siswa kelas X yang berjumlah 28 siswa. Teknik pengumpulan data dalam penelitian yakni tes dan juga angket. Intrumen dalam penelitian ini yaitu lembar soal tes kemampuan pemecahan masalah berkaitan dengan soal sistem persamaan linear serta lembar angket. Hasil penelitian menunjukkan kemampuan siswa dalam memecahkan permasalahan sistem persamaan linear dengan menggunakan bahan ajar sistem persamaan linear pada tingkat tinggi termasuk ke dalam kategori sangat rendah. kemampuan siswa dalam memecahkan masalah termasuk dalam kategori rendah kebanyakan siswa kesulitan dalam menyelesaikan masalah pada persamaan linear tiga variabel, sehingga bahan ajar yang dibuat masih perlu diperbaharui sehingga mudah dipahami oleh setiap siswa dan membantu siswa dalam memecahkan permasalahan sistem persamaan linear.
MATEMATIKA DALAM AL-QUR’AN
Authors: Surianto Surianto
Published: July 2024

Al-Qur’an merupakan kitab suci bagi umat Islam yang di dalamnya tidak hanya memuat tentang amaliah keagamaan saja tapi juga memuat tentang  sains dan ilmu pengetahuan tak terkecuali ilmu matematika. Berbicara matematika di dalam al-Qur’an, maka cukup banyak surah-surah al-Qur’an yang penjelasannya berhubungan dengan matematika, diantaranya surah Al-Kahfi, surah Al-‘Ankabuut, surah al-Baqarah dan surah an-Nisaa’. Dari latar belakang tersebut peneliti tertarik untuk meneliti lebih mendalam surah-surah yang di salah satu ayatnya terdapat rumus dasar matematika. kemuddian akan dikaji dari segi urutan penurunannya  serta hubungan dengan hikmah diturunkannya al-Qur’an secara bertahap dengan kurikulum pendidikan yang diterapkan di lembaga pendidikan. Dalam penelitian ini menggunakan metode deskriptif-kualitatif dan bersifat studi kepustakaan (library research). Teknik pengumpulan datanya dengan cara tela’ah dokumen dan Teknik analisis datanya menggunakan teknik analisis isi (content analysis). Hasil dari penelitian ini ialah 1). Surah-surah al-Qur’an yang di salah satu ayatnya terdapat pelajaran rumus dasar matematika berdasarkan urutan penurunannya ialah surah al-kahfi pada ayat ke 25 terdapat rumus penjumlahan, kemudian surah al-Ankabut pada ayat ke 14 terdapat rumus pengurangan, kemudian surah al-Baqarah pada ayat ke 261 terdapat rumus perkalian dan berikutnya surah an-Nisa’ pada ayat ke 12 terdapat rumus pembagian. 2). Tahapan mempelajari rumus dasar matematika yang ditawarkan oleh al-Qur’an yang diisyaratkan dalam tahapan penurunannya sama dengan kurikulum pendidikan yang terapkan di lembaga pendidikan formal khususnya di SD sederajat yaitu rumus dasar matematika yang pertama kali dipelajari di kelas satu SD sederajat ialah rumus penjumlahan dan rumus pengurangan, kemudian di kelas dua SD sederajat mempelajari rumus perkalian dan rumus pembagiat.
PENGEMBANGAN PERANGKAT PENGHITUNG NILAI DAN JUARA OTOMATIS BERBASIS EXCEL PADA RUBRIK PENILAIAN LOMBA POSTER
Authors: Daniarti Daniarti , Havizul Havizul
Published: July 2024

Penelitian ini bertujuan untuk membantu, mempermudah dan mempercepat tugas juri dalam melakukan penilaian terhadap hasil karya peserta lomba dalam perlombaan desain poster di acara Milad ke-2 Prodi Tadris Matematika FTIK IAIN Pontianak. Jenis penelitian yang digunakan adalah penelitian & pengembangan (RnD) dengan produk utama yang dihasilkan berupa perangkat penghitung nilai dan juara otomatis berbasis excel untuk lomba desain poster. Adapun model pengembangan yang digunakan adalah model Four-D yang terdiri atas empat tahap pengembangan, yaitu Define (Pendefinisian), Design (Perancangan), Develop (Pengembangan), dan Disseminate (Penyebaran). Perangkat penilaian berbasis excel ini diimplementasikan dalam kegiatan lomba desain poster yang digelar oleh Prodi Tadris Matematika dalam rangka Milad ke-2. Hasil implementasi menunjukkan perangkat ini dapat menghitung total skor dan nilai penentu juara lomba secara cepat dan realtime segera setelah ketiga juri selesai memasukkan penilaian, serta menampilkan nama peserta yang menjadi juara I, II, III, dan IV, sehingga perangkat ini sangat efektif dan efisien digunakan sebagai perangkat penghitung otomatis nilai dan juara dalam lomba desain poster.
EKSPLORASI ETNOMATEMATIKA MATERI GEOMETRI PADA MOTIF KAIN SONGKET MELAYU PONTIANAK
Authors: Nursila Risa , Saputri Sri Nurlailah , Zulkarnain Zulkarnain
Published: July 2024

Kebudayaan dapat digunakan untuk menggali konsep matematika sebagai upaya mendekatkan matematika dengan realistis dan persepsi masyarakat. Dan aspek kebudayaan ini bisa dijadikan bahan pembelajaran matematika di sekolah. Oleh karena itulah penelitian ini bertujuan untuk mengeksplorasi unsur serta konsep dari geometri pada kain songket melayu Pontianak menurut sudut pandang etnomatematika. Penelitian ini menggunakan metode penelitian kualitatif, pengumpulan data yang dilakukan dengan cara studi literatur. Bentuk penelitian ini ialah penelitian eksploratif melalui pendekatan etnografi. Hasil penelitian ini menunjukan bahwa motif-motif yang terdapat pada kain songket melayu Pontianak ditemukan unsur bangun datar geometri yakni belah ketupat, lingkaran dan jajar genjang. Juga terdapat konsep geometri transformasi yakni refleksi (pencerminan), translasi (perpindahan), dan dilatasi (pembesaran atau pengecilan) yang dapat dijadikan sumber belajar materi geometri.