bluuebunny/crossref_metadata_2025 huggingface dataset:
Soft tissue reconstruction of low voltage electric burn injuries of the thumb and first web space by the first dorsal metacarpal artery island flap: a three-year study from Eastern India
Authors: Gupta Madhumita , Jash Prabir Kumar
Published: March 2020

Background: Complex soft tissue defects of thumb and first web space are a reconstructive challenge. Low voltage electric burns of the hand commonly result in localised and deep soft tissue destruction. The first dorsal metacarpal artery flap (FDMA) is an attractive local flap option to reconstruct these. This study illustrates our experience with the same.Methods: Between March 2014 and February 2017, 16 patients with complex soft tissue defects of thumb and first web space resulting from low voltage electric burns underwent reconstruction with the FDMA flap and subsequent structured hand therapy. In the follow up visits objective assessment of hand function included tests of mobility using Kapandji Score, sensory evaluation with static 2 point discrimination and cortical reorientation. The Subjective Satisfaction Score was used to ascertain the patient’s overall perception of aesthetic and functional outcome.Results: Majority (43.75%) of the patients had defects involving the thumb IP joint. No case of complete flap failure was noted. In a mean follow-up of 11.5 months the reconstructed thumb showed return of good protective sensation as well as mobility. Though cortical reorientation was complete in only 18.75 %, it did not substantially impede hand functioning. All patients were satisfied with the functional and aesthetic result.Conclusions: In cases of low voltage electric burn injuries the FDMA flap is a reliable reconstructive option for small to moderate sized complex defects of thumb and first web space. It has minimal donor site morbidity and can be accomplished in a relatively simple single stage procedure.
On the Properties of Algebraic Geometric Codes as Copy Protection Codes
Authors: Deundyak Vladimir M. , Zagumennov Denis V.
Published: March 2020

Traceability schemes which are applied to the broadcast encryption can prevent unauthorized parties from accessing the distributed data. In a traceability scheme a distributor broadcasts the encrypted data and gives each authorized user unique key and identifying word from selected error-correcting code for decrypting. The following attack is possible in these schemes: groups of c malicious users are joining into coalitions and gaining illegal access to the data by combining their keys and identifying codewords to obtain pirate key and codeword. To prevent this attacks, classes of error-correcting codes with special c-FP and c-TA properties are used. In particular, c -FP codes are codes that make direct compromise of scrupulous users impossible and c -TA codes are codes that make it possible to identify one of the aackers. We are considering the problem of evaluating the lower and the upper boundaries on c, within which the L-construction algebraic geometric codes have the corresponding properties. In the case of codes on an arbitrary curve the lower bound for the c-TA property was obtained earlier; in this paper, the lower bound for the c-FP property was constructed. In the case of curves with one infinite point, the upper bounds for the value of c are obtained for both c-FP and c-TA properties. During our work, we have proved an auxiliary lemma and the proof contains an explicit way to build a coalition and a pirate identifying vector. Methods and principles presented in the lemma can be important for analyzing broadcast encryption schemes robustness. Also, the c-FP and c-TA boundaries monotonicity by subcodes are proved.
Modern Approaches to Detect and Classify Comment Toxicity Using Neural Networks
Authors: Morzhov Sergey V.
Published: March 2020

The growth of popularity of online platforms which allow users to communicate with each other, share opinions about various events, and leave comments boosted the development of natural language processing algorithms. Tens of millions of messages per day are published by users of a particular social network need to be analyzed in real time for moderation in order to prevent the spread of various illegal or offensive information, threats and other types of toxic comments. Of course, such a large amount of information can be processed quite quickly only automatically. that is why there is a need to and a way to teach computers to “understand” a text written by humans. It is a non-trivial task even if the word “understand” here means only “to classify”. the rapid evolution of machine learning technologies has led to ubiquitous implementation of new algorithms. A lot of tasks, which for many years were considered almost impossible to solve, are now quite successfully solved using deep learning technologies. this article considers algorithms built using deep learning technologies and neural networks which can successfully solve the problem of detection and classification of toxic comments. In addition, the article presents the results of the developed algorithms, as well as the results of the ensemble of all considered algorithms on a large training set collected and tagged by Google and Jigsaw.
Estimation of Length of Node-to-Node Paths Distribution in the Global Network
Authors: Kononova Alexandra I. , Gorodilov Alexey V.
Published: March 2020

The experiment aimed at finding a distribution of path lengths between nodes in the global network and an estimation of parameters of that distribution is described.In particular, the method of measurement of path length with traceroute utility of the GNU/Linux system and limitations on the selection of nodes imposed by traceroute are described. e measurement results are provided and high values of skewness and kurtosis for all resulting distributions are noted. Simulation model of this experiment was developed to test the experiment validity in the determination of distribution parameters in the global network. This model is also described. It is shown that high values of skewness and kurtosis of the measured distributions are not the result of the measurement technique, therefore the global network could not be described by the Barabasi–Albert ´ model. Several most viable hypotheses explaining diffierences in skewness and kurtosis of experimentally obtained pathlength distribution estimations and values derived from the Barabasi–Albert model are listed. Results of diffierent hypotheses ´ simulations are provided. It is shown that the most fitting hypothesis is that definitive influence on skewness and kurtosis of path-length distribution estimations is caused by the quasi pre-fractal structure of the global network.
Parallel Algorithm for Solving the Graph Isomorphism Problem
Authors: Vasilchikov Vladimir Vasilyevich
Published: March 2020

In this paper, we offer an efficient parallel algorithm for solving the Graph Isomorphism Problem. Our goal is to construct a suitable vertex substitution or to prove the absence of such. The problem is solved for undirected graphs without loops and multiple edges, it is assumed that the graphs can be disconnected. e question of the existence or absence of an algorithm for solving this problem with polynomial complexity is currently open. Therefore, as for any time-consuming task, the question arises of accelerating its solution by parallelizing the algorithm. We used the RPM ParLib library developed by the author as the main tool to program the algorithm. This library allows us to develop effective applications for parallel computing on a local network in the .NET Framework. Such applications have the ability to generate parallel branches of computation directly during program execution and dynamically redistribute work between computing modules. Any language with support for the .NET Framework can be used as a programming language in conjunction with this library. For our experiments, we developed some C# applications using this library. The main purpose of these experiments was to study the acceleration achieved by recursive-parallel computing. Specially generated random regular graphs with varying degrees of vertices were used as initial data. A detailed description of the algorithm and its testing, as well as the results obtained, are also given in the paper.
The Determination of Distances between Images by de Rham Currents Method
Authors: Chukanov Sergey N.
Published: March 2020

The goal of the paper is to develop an algorithm for matching the shapes of images of objects based on the geometric method of de Rham currents and preliminary affine transformation of the source image shape. In the formation of the matching algorithm, the problems of ensuring invariance to geometric image transformations and ensuring the absence of a bijective correspondence requirement between images segments were solved. The algorithm of shapes matching based on the current method is resistant to changes of the topology of object shapes and reparametrization. When analyzing the data structures of an object, not only the geometric form is important, but also the signals associated with this form by functional dependence. To take these signals into account, it is proposed to expand de Rham currents with an additional component corresponding to the signal structure. To improve the accuracy of shapes matching of the source and terminal images we determine the functional on the basis of the formation of a squared distance between the shapes of the source and terminal images modeled by de Rham currents. The original image is subjected to preliminary affine transformation to minimize the squared distance between the deformed and terminal images.
O caso Herzog e outros versus Brasil: diálogo das cortes ou monólogo jurídico?
Authors: Mendonça Filho Alberto Hora , Jaborandy Clara Cardoso Machado
Published: March 2020

Em decorrência da internacionalização das normas jurídicas, os tratados internacionais detêm relevante papel na proteção dos direitos humanos. Assim, questiona-se: a ordem jurídica brasileira está aberta ao Direito Internacional dos Direitos Humanos, em especial, com relação às violações aos direitos humanos ocorridas durante a Ditadura Militar (1964-1985)? Visto isso, importante estudar, criticamente, a integração regional do Brasil ao Sistema de Proteção Regional aos Direitos Humanos, a partir do caso Herzog e outros vs. Brasil. Utiliza-se, para tanto, uma pesquisa qualitativa, sendo bibliográfica-documental, já que foram consultados artigos científicos e obras jurídicas, como regras legais, convencionais e constitucionais. Adotou-se ainda o método dedutivo. Ao cabo, conclui-se pela necessidade do diálogo das cortes, evitando-se o paroquialismo, como caractere da justiça.
O poder simbólico do discurso judicial – a construção de uma “cultura jurídica” no contexto da judicialização das políticas públicas
Authors: Ximenes Julia Maurmann
Published: March 2020

O presente artigo problematiza a judicialização das políticas públicas a partir da construção de uma cultura jurídica que utiliza o argumento de autoridade no discurso jurídico. Analisando o conteúdo de sentenças concedendo o Benefício de Prestação Continuada o artigo reflete sobre um habitus que valoriza um direito jurisprudencial em detrimento das definições postas pela política pública.
O sentido da(s) fórmula(s) de Radbruch: notas sobre uma controvérsia ainda atual
Authors: Ramos Andre Luiz Arnt
Published: March 2020

A(s) Fórmula(s) de Radbruch consiste(m) em importante marco para os desdobramentos da Teoria e da Filosofia do Direito a partir do Segundo Pós-Guerra. Seu alcance e sentido são objeto de acalentados debates pela literatura especializada, na qual se destacam as leituras de Robert Alexy e de Brian Bix. O primeiro sustenta que a(s) Fórmula(s) seria(m), ao mesmo tempo, proposição(ões) acerca do conceito de Direito e prescrição(ões) para a decisão judicial. O segundo, a(s) tem apenas como esta(s) última(s). Júlio Aguiar de Oliveira, após detida análise destas diferentes leituras, desbrava um terceiro caminho, no qual a(s) Fórmula(s) é(são) apenas proposição(ões) acerca do conteúdo do Direito. Defronte a este pano de fundo, o presente trabalho propõe uma recolocação dos termos do debate, a partir do escrutínio dos argumentos apresentados por cada autor, com ênfase às diferentes (e inconciliáveis) perspectivas de que partem. Sugere, ao final, que a consideração do contexto no qual veio a lume o texto continente da(s) Fórmula(s) corrobora a tese de Bix, no sentido de que ela(s) seria(m), ao menos primordialmente, prescrição(ões) à decisão judicial.
O prazo de internação provisória é prorrogável? Uma análise das decisões do Tribunal de Justiça do estado do Rio Grande do Sul no ano de 2018
Authors: Dias Felipe Da Veiga , Silva Patrícia Silveira da
Published: March 2020

O presente artigo analisou dezenove decisões proferidas pelo Tribunal de Justiça do Estado do Rio Grande do Sul, no período de janeiro a outubro de 2018, partindo de um método indutivo, para verificar como estava se decidindo sobre a possibilidade da prorrogação do prazo de internação provisória, vez que a legislação atual estabelece ser improrrogável. A pesquisa também tinha como objetivo saber quais seriam os atos infracionais que possivelmente autorizariam sua prorrogação, além de selecionar os argumentos jurídicos e subjetivos/discricionários utilizados pelo Tribunal. O marco teórico da pesquisa se concentrou na análise da legislação vigente, voltada para a teoria da proteção integral, a partir de um viés criminológico crítico, com um método predominantemente dedutivo. O resultado obtido demonstra divergência entre duas Câmaras Cíveis do Tribunal, sendo que uma delas sempre autorizou a prorrogação, independentemente do ato infracional praticado, além de ter utilizado um modelo padrão de decisão, com fundamentos majoritariamente discricionários. Por sua vez, a outra Câmara somente em uma das decisões autorizou a prorrogação, porém, em todas elas deixou aberta uma margem para a prorrogação em casos excepcionais, sem, contudo, definir quais casos seriam esses. Como conclusão, a pesquisa demonstrou que embora a sociedade brasileira atual esteja vivendo em uma era pós-democrática, onde cada vez mais os direitos e garantias fundamentais não serão efetivados, e todos órgãos estarem comprometidos com o capital, não pode ser descartado que o futuro da legislação tende a trazer muitos benefícios para essa área que durante muito tempo foi subalternizada e marginalizada.
The Impact of Migration on a Regulated Rental Market
Authors: Tyrcha Adam Alexander
Published: March 2020

Throughout the 20th century, the Swedish rental market has generally been heavily regulated, with both a rental queue in place, as well as generally fixed rents, with limited ability to vary these. Though these systems remain in place, in the 21st century, a number of deregulatory measures have been taken. Meanwhile, evolving migration flows and strong humanitarian migration in particular have continued. These developments combined mean that now more than ever, impacts of migration on the rental housing market are increasingly likely. This paper investigates the relationship between foreign-born and internal migration and rents on the housing market. Findings suggest that foreign-born migration, and refugees in particular, impact rents, especially in major cities.
Udział kompleksów SWI/SNF opartych na aktywności BRG1 w determinowaniu fenotypu komórek nowotworowych
Authors: Sobczak Maciej , Strachowska Magdalena , Robaszkiewicz Agnieszka
Published: March 2020

ATP-zależne kompleksy remodelujące chromatynę stanowią ważny element epigenetycznego mechanizmu regulującego transkrypcję. Posiadają one zdolność do wstawiania, usuwania i przesuwania nukleosomów w obrębie elementów regulatorowych genów kontrolując w ten sposób dostępność DNA dla maszynerii transkrypcyjnej. Jednym z czterech zidentyfikowanych i opisanych dotychczas kompleksów jest SWI/SNF, w którym enzymatycznymi „motorami” są białka BRM i BRG1. Rosnąca liczba opublikowanych prac wskazuje na udział BRG1 w patofizjologii niektórych typów nowotworów, ponieważ aktywność tego enzymu odpowiada za ekspresję genów, których produkty odpowiadają za proliferację, naprawę DNA, transport przezbłonowy czy metabolizm. Inhibitory BRG1 i enzymów, które determinują aktywność BRG1 lub znakują histony mające ulec przemieszczeniu przez BRG1 mogą stać się w przyszłości alternatywą dla obecnie stosowanych w terapiach związków hamujących wzrost guzów lub suplementem zwiększającym wrażliwość nowotworów na działanie leków przeciwnowotworowych.
Anti-Breast Cancer Activities of 8-Hydroxydaidzein by Targeting Breast Cancer Stem-Like Cells
Authors: Rajabi Sadegh , Shojaee Maryam , Malmir Ali , Rezaei Tavirani Mostafa , Noori Shokoofe
Published: March 2020

Purpose: Cancer stem cells (CSCs) play an important role in various stages of cancer development and therapy refractoriness. 8-Hydroxydaidzein (8-OHD) has revealed anti-cancer activity in different tumors. Accordingly, we aimed to assess the effects of 8-OHD on the suppression of breast cancer stem-like cells (BCSCs). Methods: The anti-proliferative and pro-apoptotic properties of 8-OHD were examined by MTS assay and flowcytometry. The expression levels of stemness markers and JAK2/STAT proteins were measured by quantitative real time-PCR (qRT-PCR) and western blotting, respectively. Results: 8-OHD significantly decreased three out of six stemness markers and remarkably reduced viability and induced apoptosis of spheroidal and parental cells compared to controls. Further experiments using CD95L, as a death ligand, and ZB4 antibody, as an extrinsic apoptotic pathway blocker, showed that 8-OHD induced apoptosis through the intrinsic pathway, proposing a mechanism by which 8-OHD triggers apoptosis. Results of western blot analysis also revealed a marked decline in the phosphorylation of JAK2 and STAT proteins. Conclusion: Our study, for the first time, elucidated an anti-BCSC activity for 8-OHD via decreasing stemness markers, inducing toxicity and stimulating apoptosis in these cells and parental cells. Our results also suggested a novel mechanism by which 8-OHD induces apoptosis in BCSCs.
Introdução
Authors: Kato Danilo Seithi , Narita Felipe Ziotti
Published: March 2020

Introdução - v. 2, n. 2, 2012
Introdução
Authors: Kato Danilo Seithi , Narita Felipe Ziotti
Published: March 2020

Introdução - v. 3, n. 1, 2013
Introdução
Authors: Kato Danilo Seithi , Narita Felipe Ziotti
Published: March 2020

Introdução - v. 3, n. 2, 2013
Introdução
Authors: Kato Danilo Seithi , Narita Felipe Ziotti
Published: March 2020

Introdução - v. 5, n. 2, 2015.
Editorial
Authors: Kato Danilo Seithi , Narita Felipe Ziotti
Published: March 2020

Editorial - v. 9, n. 1, 2019.
Práticas experimentais aplicadas ao ensino de Química como ferramenta para a aprendizagem
Authors: Peixoto Sandra Cadore , Solner Tiago Barboza Baldez , Soares Gabriel De Oliveira , Fantinel Leonardo
Published: March 2020

Considerando que os recursos didáticos podem ser facilitadores dos processos de ensino e aprendizagem, a proposta deste estudo é relatar uma experiência com a utilização de atividades experimentais na sala de aula de Química/Ciências. Para tal, inicialmente elaborou-se um material de apoio, intitulado “Aprendendo Química”, visando favorecer a execução das atividades experimentais conjugadas com as teóricas. Após, as atividades foram aplicadas em uma turma do Ensino Fundamental de uma Escola Pública do município de Paraíso do Sul - RS, constituída por dezessete alunos do 9º ano, buscando incentivar professores à diversidade de atividades na prática docente e despertar nos alunos o interesse em adquirir conhecimento. Após o desenvolvimento das atividades experimentais, solicitou-se aos alunos que preenchessem um questionário constituído por quatro questões objetivas, com o intuito de avaliar o contexto do aluno perante a Ciência. Frente a isso, a utilização das atividades experimentais descritas neste trabalho, contribuíram para os processos de ensino e aprendizagem relacionados à Ciências/Química, pois permitiu que os alunos se apropriassem dos conhecimentos de forma a poder transformar o seu aprendizado. Os resultados evidenciaram aspectos positivos para a aprendizagem dos alunos, instigando o protagonismo do estudante. Por fim, a experimentação teve um papel relevante na aprendizagem escolar.
Educação Profissional e lazer: (con)formar o futuro trabalhador?
Authors: Guimarães A. Vitor
Published: March 2020

Este artigo resulta de pesquisa de doutoramento cujo objetivo foi delimitar e analisar os significados das relações estabelecidas entre educação, lazer e trabalho no interior de escolas de educação profissional e tecnológica (EPT), com base nas atividades e nas manifestações culturais relacionadas ao lazer e incorporadas aos processos educacionais e ao cotidiano dessas escolas. No recorte da realidade estudada, a pesquisa foi desenvolvida em duas escolas da Rede Federal de Educação Profissional, Científica e Tecnológica – o Colégio Técnico da UFMG e os campi I e II do Cefet-MG, em Belo Horizonte –, tomando-se como princípio fundamental de pesquisa a dialética materialista. Tendo como principal fonte de dados a realidade estudada no interior dessas escolas, os procedimentos metodológicos levaram em conta dois movimentos de pesquisa interligados, necessariamente integrados por correlações em espiral: a pesquisa bibliográfica e documental; e a pesquisa de campo, propriamente dita. No recorte tratado aqui, busca-se evidenciar as contradições e aspectos relacionados às atividades e manifestações culturais relacionadas ao lazer como parte dos processos educacionais nas escolas pesquisadas, considerando sua possível articulação a uma formação profissional conformada ao mercado de trabalho, ao mesmo tempo em que revelam-se suas potencialidades de emancipação e busca de autonomia e liberdade.
Neurogastronomia, a ciência em benefício da gastronomia
Authors: Santos Maiara Dos
Published: March 2020

ResumoO presente artigo abordará neurogastronomia, uma ciência relativamente nova que estuda o sistema que envolve o paladar e todo o processo perceptivo da experiência gastronômica a nível sensorial.Todos os sentidos são imprescindíveis na definição dos gostos e sabores. O olfato é considerado o maior aliado do paladar na formação dos sabores. Se não sentimos os cheiros, não conseguiremos identificar os sabores de maneira adequada.A formação dos sabores não se restringe apenas ao paladar e ao olfato, a visão e a audição também são fundamentais.Charles Spence[1] o precursor da área, ressalta que a iluminação do ambiente e a cor da louça interferem no sabor final dos alimentos. Em uma experiência com o chef Ferran Adrià, Spence provou que um mousse de morango fica 10% mais doce em um prato branco do que em um prato preto e ainda mais doce se o prato for redondo.A percepção dos sons tanto do ambiente quanto da crocância dos alimentos, fazem parte da experiência dos sentidos do comensal.A gastronomia se apropria desse conhecimento e traz além da questão nutricional da comida o despertar da sensorialidade e da sinestesia provocada pelas cores, sabores, texturas e aromas, retroalimentando a carga sensorial, emocional e cognitiva..             Este estudo propõe uma breve abordagem sobre o tema neurogastronomia ressaltando a importância do tema para a gastronomia, indústria alimentícia, para a nutrição e medicina, pois, pode auxiliar na recuperação do paladar de pessoas que fazem quimioterapia, dependentes químicos e no auxílio de distúrbios alimentares.
BENEFÍCIOS DA MELATONINA NA ENXAQUECA
Authors: Bento Diana Bittencourt , Rigo Flavia Rigo
Published: March 2020

A enxaqueca (migrânea) é uma doença neurológica crônica e incapacitante. Sua fisiopatologia é multifatorial, e as crises são deflagradas por fatores desencadeantes, que variam na sua intensidade e diversidade. Mecanismos como o genético, hormonal, ambiental e comportamental são destacados, sendo que as bases biológicas ocorrem através da intermediação de neurotransmissores. Atualmente, não existe tratamento padronizado para o completo alívio dos sintomas da enxaqueca, apenas terapia que promove uma melhora significativa na qualidade de vida dos pacientes. A melatonina, produzida a partir da glândula pineal é um hormônio que está envolvido no controle de ritmos circadianos e exerce uma série de efeitos farmacológicos. A melatonina medeia suas ações através dos receptores de melatonina MT1 / MT2. As síndromes de dor crônica são frequentemente associadas à desincronização de ritmos circadianos e biológicos, que também causam distúrbios no ciclo sono-vigília. Os efeitos analgésicos mediados pela melatonina parecem envolver β-endorfinas, receptores GABA, receptores opióides e a via óxido nítrico-arginina. A eficácia da melatonina como agente analgésico e ansiolítico foi demonstrado em vários modelos animais de dor. Estudos clínicos também estão evidenciando o efeito analgésico da melatonina, em diferentes condições patológicas, o que o torna uma alternativa promissora para o tratamento de dores refratárias, como a enxaqueca.
Perfil epidemiológico da esquistossomose mansônica em Minas Gerais
Authors: Silva José Paula
Published: March 2020

Introdução – A esquistossomose é uma parasitose endêmica em Minas Gerais, sendo o estado responsável pela metade das notificações no Sistema Nacional de Agravos. Objetivos – Determinar o perfil da parasitose em Minas Gerais. Materiais e métodos – A partir de dados de notificações entre os anos de 2007 a 2014, foram feitas as comparações entre as variáveis relacionadas a esquistossomose em Minas Gerais, comparadas a população do estado, e as notificações nos demais estados do Brasil no mesmo período. Resultados - Os dados sobre a esquistossomose em Minas Gerais mostraram um maior número de notificações em adultos, de área urbana. Discussão – Os resultados demonstram que apesar do maior número de notificações ser em área urbana a maior proporção é na área rural, e com menor escolaridade. Conclusão - O indivíduo típico de Minas Gerais com esquistossomose (quando da notificação do primeiro sintoma), mora na região urbana é do sexo masculino, possui entre 20 a 39 anos, seu grau de instrução é de 1ª a 4ª série do ensino fundamental incompleto e quando tratado evolui para a cura.
NIKOLAY FEDOROVICH GAMALEYA - TALENTED ORGANIZER OF MEDICAL SCIENCE (ON THE 160TH ANNIVERSARY OF HIS BIRTH)
Authors: Knopov Mikhail Sh. , Taranukha V. K
Published: March 2020

In the article, there is presented the life and career of a prominent domestic epidemiologist, the talented organizer of the medical science, well-known public figure, a wonderful teacher, professor, Nikolay Fedorovich Gamaleya.
FEBRILE INFECTION-RELATED EPILEPSY SYNDROME (FIRES): COMPLICATED DIAGNOSIS AND CASE REPORT
Authors: Shakaryan Armen K. , Kholin A. A , Turkot N. V , Shakhmaeva D. V , Mitrofanova I. V
Published: March 2020

Febrile infection-related epilepsy syndrome (FIRES) is an acute disease provoked by the nonspecific febrile illness with the development of refractory status epilepticus. It frequently occurs in previously healthy children. The pathogenesis of this syndrome is still unknown. The leading initial symptoms include acute fever, seizures, consciousness disorders and imitate neuroinfection or autoimmune pathology of CNS. These features make diagnosis extremely difficult, and there are in addition some difficulties with the verification of the diagnosis. Interpretation of MRI results allows identifying involved parts of the brain. However, the EEG record pattern is not precise. We report a clinical case of FIRES occurred in a 14-year-old previously healthy boy. The disease began similarly to an acute neuroinfection disease with prolonged refractory status epilepticus
DISORDERS OF THE NERVOUS AND CARDIOVASCULAR SYSTEMS AT THE STAGE OF PERSISTENT INFECTION (ORGANIC LESIONS)
Authors: Nafeev Aleksandr A. , Kozlova T. G , Kotkova G. P , Tamarova L. N , Nikonov M. E
Published: March 2020

The authors give a description of the established case of Ixodes tick borreliosis (ITB) in the boy of 5 years associated with disorders of the central nervous and cardiovascular systems due to the delayed diagnosis. The peculiarity of this case was the presence of the initial neurological deficit
HIV INFECTION MANIFESTATIONS IN GASTROENTEROLOGY: EMERGING ISSUES IN PATHOGENESIS
Authors: Khalilulin T. R , Bessarab Timur P. , Mazus A. I , Nagibina M. V
Published: March 2020

The review provides current data on the pathogenesis of HIV infection, focusing on its gastrointestinal manifestations. The authors deal with specific characteristics of the digestive system, which play a key role in infecting, preserving HIV reservoirs, and HIV-caused disease progressing. The study addresses various aspects of the gastroenterological pathology combined with the HIV infection.
DEPENDENCE OF GRAVITY OF LIVER DISEASE FROM REPLICATIVE ACTIVITY OF VIRUS HEPATITIS B AND D
Authors: Abdukadirova M. A , Khikmatullaeva Aziza Saydullaevna , Hodjaeva M. E , Kan N. G
Published: March 2020

The article is devoted to the study of the connection between the replicative activity of HBV DNA and HDV RNA with the formation of CP at all stages of development of chronic hepatitis of viral nature, evidence that a high level of HBV DNA is a pronounced predictor of liver cirrhosis (LC) progression. The purpose of the study is to study the dependence of the severity of liver damage on the replicative activity of the hepatitis B virus and D. Materials and methods. The study included 67 patients with cirrhosis of the liver in the outcome of viral hepatitis B and 140 patients with an outcome of cirrhosis against the background of chronic hepatitis B + D. The clinical stage of LC was determined according to the Child-Puy classification. Results. A direct link has been established between the increase in the viral load of HBV DNA and HDV RNA with the duration of the disease. A tendency was revealed to increase the severity of the disease in patients with LC of viral etiology with an increase in viral load. The biochemical indices of blood showed a tendency to an increase in the level of cytolytic enzymes against the background of high replicative activity of HBV DNA and HDV RNA. The conclusion. Thus, a high level of HBV DNA is a pronounced predictor of the progression of LC at all stages of the pathological process.
CASES OF LEPTOSPIROSIS FOLLOWING INTERNATIONAL TRAVEL
Authors: Sayfullin Ruslan Faritovich , Zvereva N. N , Karan L. S , Petrov E. M , Bazarova M. V , Sayfullin M. A
Published: March 2020

We present an analysis of 28 leptospirosis cases, associated with abroad traveling, and registered from 2011 to 2017 years. The relative ratio of leptospirosis with other imported infectious diseases is shown, and clinical and epidemiological features of imported leptospirosis cases were described.
PROFESSOR NIL FEDOROVICH FILATOV (1847 - 1902) - PEDIATRIC-INNOVATOR, CLINICIAN AND TEACHERS (TO THE 170TH ANNIVERSARY OF THE BIRTHDAY)
Authors: Morgoshiia T. Sh
Published: March 2020

The article contains the main milestones of life and career of professor Filatov. It was noted that during 25 years of scientific and teaching activity N.F. Filatov has made a significant contribution to the development of world Pediatrics. He is the author of over 70 scientific works, including “a Short textbook of pediatric diseases” (1893), aged 12 editions, and “Clinical lectures” (1900). His monograph “Lectures on acute infectious diseases” (1885) through 4 editions, “Semiotics and diagnosis of childhood diseases” (1890) - 9 editions, it is translated into German, Czech, Italian, Hungarian and French. In the monographs and manuals N.F. Filatov studied many of pokoleniya-pediatricians. He described the infectious disease named Filatov scarlatinal rubella. She was later described by the British physician Duxom; one of the presently used names of the disease - a disease Filatov-Dukes. In the first edition of “Lectures on infectious diseases” N.F. Filatov described is not known until the time of infectious mononucleosis, which he called idiopathic inflammation of the cervical lymphatic glands. The disease is now often called a disease Filatov. In 1895 N. F. Filatov, described an important diagnostic sign of measles is the appearance of catarrhal period of illness 1 - 2 days before appearance of rash spot grayish-white lesions on the mucosa of lips and cheeks. As was established later, this sign was first described by A.P. Belsky in 1890, then regardless of him. F. Filatov, and in 1896 Aplicom. In the literature, this symptom is known as spots Belsky-Filatova-Koplik. N.F. Filatov described the pathogenesis of some forms of edema syndrome in children, published works on prolonged afebrile forms of the flu. N. F. Filatov developed a clinical-physiological direction in Pediatrics. He created a large school of domestic pediatricians. Among his students were V.I. Molchanov and G.N. Speransky.
INDICATORS OF HEMOSTASIS IN PATIENTS WITH CHRONIC HEPATITIS C
Authors: Galeeva N. V , Kravchenko I. E
Published: March 2020

Goal of the study is to reveal the particular features of hemostasis in patients with chronic hepatitis C in dynamics of natural course of disease. Materials and methods. The indices of hemostasis in 535 patients with chronic hepatitis C were assessed by the number of platelets, degree of their aggregation with the use of inductor of adenosine triphosphate and without it (spontaneous aggregation of platelets). Coagulative hemostasis was analyzed by the activated partial thromboplastin time, antitrombin III, prothrombin ratio, prothrombin time, fibrinogen concentration in plasma and international normalized ratio. Based on the number of Tr, typical for the disseminated intravascular coagulation syndrome, conditionally the patients were divided into 3 groups: I group - hypercoagulability; II - transient phase between hyper and hypocoagulation and III- hypocoagulation, which also included patients with liver cirrhosis. Results and discussion. Independent on the phase of disseminated intravascular coagulation syndrome, increase of aggregation of Tr with the growth of maximal amplitude was observed. The main part of studied indices of coagulative hemostasis indicated at the condition of hypocoagulation in patients with chronic hepatitis C - this is significant increase of activated partial thromboplastin time, prothrombin time, international normalized ratio and decrease of fibrinogen concentration in the studied groups by the phases of disseminated intravascular coagulation syndrome. Value of antitrombin III changed oppositely, it decreased, so that plasma hemostasis tends to the hypercoagulation. Conclusion. Under the chronic hepatitis C all phases of disseminated intravascular coagulation syndrome were observed with the disorder of thrombocytic coagulative hemostasis. There was followed up multidirectional change of hemostasis which obtained in the most cases character of delitescent course of disseminated intravascular coagulation syndrome.
THE ANALYSIS OF CASE OF MIDDLE EAST RESPIRATORY SYNDROME IN NO ENDEMIC REGIONS
Authors: Petrov A. A , Karulina N. V , Sizikova T. E , Lebedev V. N , Borisevich Sergey V.
Published: March 2020

The some epidemiologic characteristics of etiologic agent of disease, possible main and intermediate reservoirs of agent in the nature, mechanism of agents transmission, modern methods of diagnostics and identification of agent, perspective trends of elaboration of therapeutics for special prophylactic and current of diseases are viewed. The possibility of existing in no endemic regions outbreaks of MERS as the result of accidental acquire by persons, arrival from Middle East countries, determines of elaboration of complex effective epidemic measures.
SERPEGINATING DERMATITIS: A CASE OF TISSUE (CUTANEUS) HELMINTHIASIS OR «LARVA MIGRANS SYNDROME»
Authors: Dikaya L. V , Minkina O. V , Dvornikov A. S , Shahmardanov M. Z , Gaydina T. A , Skripkina P. A
Published: March 2020

In connection with the increasing incidence of patients with skin manifestations of helminth infections after visiting endemic zones, dermatovenereologists need to know the skin manifestation of tropical countries diseases. At present, serpeginating dermatitis often causes difficulties in the diagnosis and choice of treatment tactics. Tissue helminthiasis is a skin disease caused by the parasitization of migratory zohelminth larvae, for which a person is an intermediate host. Infection is most often affected by people who come into contact with warm, moist, sandy soil contaminated by dog and cat feces. This article presents a clinical case of a patient with a diagnosis of the skin form of larva migrans syndrome treated with two courses of the anthelmintic drug of the benzimidazole group in a daily dose of 800 mg with regressing the dermatological manifestations of the disease within 2 weeks from the start of specific therapy.
COMMUNITY-ACQUIRED PNEUMONIA IN INFECTIOUS HOSPITAL PATIENTS: THE DEVELOPMENT OF RESISTANCE TO ANTIMICROBIALS
Authors: Avdeeva Marina G. , Shubina G. V. , Ganzha A. A. , Zhuravleva E. V.
Published: March 2020

The aim of the work was to study the structure, level and dynamics of resistance to antimicrobial drugs of the most common types of microorganisms in patients with community-acquired pneumonia (CAP) in the Krasnodar Territory, on the example of patients treated in a regional specialized infectious hospital for the period 2015-2017. Materials and methods. The results of bacteriological tests of expectoration, including 523 positive strains of microorganisms, are analyzed. The analysis does not include strains with hospital multidrug resistance. A bacterioscopy with Gram stain and sputum seeding on plate-like artificial nutrient media were carried out. Identification of the pathogen was performed by mass spectrometry using MALDI-TOF technology (Microflex LT, Bruker, Germany), phenotypically identified resistance mechanisms were confirmed on the automatic analyzer Vitek II Compact (BioMérieux, France). The sensitivity to antimicrobials was determined by the disc-diffusion method in the Müller-Hinton medium, using the disks by Bio-Rad, France. The antibioticogram was analyzed on the apparatus “Adagio” (Bio-Rad, France). Results. In the etiologic structure of community-acquired pneumonia, Streptoccocus pneumonia prevails in patients hospitalized in an infectious hospital in the Krasnodar Territory, which is determined in 73.56% of confirmed cases, which is twice as high as an average in Russia. Staphylococcus aureus was determined in 9.04% of casesd, with fluctuations in different years from 3.8% to 12.1%. Klebsiella pneumoniae was found in 4.61%, with variations from 1.7% to 9.3%. Pseudomonas aeruginosa was registered in 4.6%, altered from 1.3% to 7.8%. Other microorganisms were represented with Enterobacteriaceae family, 8.2% of the cases. The resistance of wild strains of microorganisms isolated at CAP to a number of antimicrobial agents has been established. A number of negative trends were noted: the emergence of pneumococcal strains resistant to beta-lactam antimicrobial drugs (benzylpenicillin MIC < 2μg); an increase in the resistance of pneumococci to macrolides, tetracyclines, sulfonamides. There is a high percentage of Staphylococcus aureus (80%) producing penicillinase, and an increase in their resistance to macrolides. A high level of Pseudomonas aeruginosa resistance to 3-rd and 4-th generation cephalosporins is noted. Conclusion. The obtained data determine the need for further monitoring of regional resistance of microorganisms, which will allow both adequate start therapy and the possibility of its timely correction. In the practical work of a doctor, it is important not only to be guided by local data on the resistance of microorganisms to antimicrobial drugs, but also to analyze the possible causes of its occurrence with the establishment of individual risk factors.
RESEARCH ANTIFUNGAL THERAPY OF OROPHARYNGEAL CANDIDIASIS IN HIV-INFECTED PATIENTS
Authors: Filina Y. S. , Volchkova Elena V. , Nesvizhskiy Yuri V. , Belaya O. F.
Published: March 2020

Modern medicine has made significant advances in the treatment of fungal infections. The problem of drug resistance of such a common conditional pathogen as Candida remains relevant for the last decade. The aims of the study were: 1) analysis of species and strain drift of Candida in patients with HIV/AIDS from oropharynx and intestine in two years; 2) the analysis of the dynamics of the sensitivity of Candida to standard antimycotic drugs. Treatment of candidiasis in HIV-infected patients leads to changes in the species and strain composition of Candida. After eradication of C. albicans which is sensitive to fluconazole, more resistant strains of other species (glabratae, krusei. tropicalis) takes its place in the biotope, which is one of the reasons for the low effectiveness of antimycotic therapy.
FEBRILE INFECTION-RELATED EPILEPSY SYNDROME (FIRES): COMPLICATED DIAGNOSIS AND CASE REPORT
Authors: Shakaryan Armen K. , Kholin A. A. , Turkot N. V. , Shakhmaeva D. V. , Mitrofanova I. V.
Published: March 2020

Febrile infection-related epilepsy syndrome (FIRES) is an acute disease provoked by the nonspecific febrile illness with the development of refractory status epilepticus. It frequently occurs in previously healthy children. The pathogenesis of this syndrome is still unknown. The leading initial symptoms include acute fever, seizures, consciousness disorders and imitate neuroinfection or autoimmune pathology of CNS. These features make diagnosis extremely difficult, and there are in addition some difficulties with the verification of the diagnosis. Interpretation of MRI results allows identifying involved parts of the brain. However, the EEG record pattern is not precise. We report a clinical case of FIRES occurred in a 14-year-old previously healthy boy. The disease began similarly to an acute neuroinfection disease with prolonged refractory status epilepticus
Estratégias de preservação para o patrimônio cultural
Authors: Cura Sara , Cardoso Diogo da Silva , Queiroz Luiz Antonio Pacheco , Viana Willian Carboni , Costa Maria Clara
Published: March 2020

As estratégias de preservação e conservação patrimonial têm lidado com conflitos de diversas ordens, segmentos e escalas. Sob este cenário complexo, o patrimônio cultural e, especificamente, sítios e bens arqueológicos, tornaram-se elementos centrais nos debates relacionados aos processos culturais, educativos, políticos e urbanísticos. O que tem atraído agentes de diferentes matizes políticas e econômicas, para satisfazer interesses que ora priorizam o lado estético do bem, ora reivindicam raízes históricas próprias. Neste sentido, a categoria patrimônio, como ferramenta analítica, será utilizada neste texto para embasar algumas considerações, em forma de ensaio, acerca dos bens arqueológicos e sobre as imbricadas práticas educativas de preservação, conservação e valorização.
Direito à memória
Authors: Zanetti Valéria Regina , Dallago Henrique Palaver , Gomes Cilene
Published: March 2020

Muitos são os dispositivos que tratam da preservação do patrimônio arqueológico, mas são poucas as ações que, de fato, atendem a esses dispositivos, sobretudo àquelas que envolvem o planejamento urbano e os setores dinâmicos da sociedade em municípios com forte crescimento urbano. Esse artigo, exploratório e reflexivo, baseado em análise qualitativa, fundamentado em evidências arqueológicas e documentos históricos, visa problematizar a forma como se tem efetivado o princípio da extroversão arqueológica, que consiste na expansão, comunicação, socialização, divulgação e publicização dos bens arqueológicos no município de São José dos Campos.
Casas de turma da ferrovia do contestado, Santa Catarina
Authors: Lino Jaisson Teixeira , Matias Everson Semler , Araujo Fabio
Published: March 2020

Pelo prisma arqueológico o presente artigo discute a contribuição histórica das casas de turmas, habitações destinadas a abrigar os funcionários responsáveis pela construção e manutenção da Linha Sul da ferrovia que ligou São Paulo ao Rio Grande do Sul, na segunda década do século XX. Não apenas a lente – da arqueologia – utilizada para analisar o passado é distinta, como é distinta também a parcela de personagens sobre a qual este estudo se debruça: os funcionários da Estrada de Ferro São Paulo – Rio Grande. Fazer emergir algum subsídio histórico, para a melhor investigação e consequente compreensão da industrialização da região do Contestado, no meio oeste do Estado de Santa Catarina, tanto das casas de turmas quanto dos turmeiros é o objetivo deste artigo. Para tanto, as reflexões contidas neste estudo projetam-se sobre dois elementos basilares: um alicerce bibliográfico e um alicerce arqueológico. As casas de turma foram estruturas habitacionais construídas ao longo da via-férrea e que serviram como moradia para famílias de trabalhadores deste empreendimento, seja durante a construção, seja durante a manutenção da ferrovia já em funcionamento.
Um espelho para Cleópatra
Authors: Caldas Marcos José de Araújo
Published: March 2020

Por um longo período, os estudos em cultura material foram negligenciados pelo debate historiográfico e apenas nas últimas décadas este vasto campo de estudos tornou-se um meio para abrir novos horizontes na pesquisa científica, especialmente àquela ligada à História Antiga. Este breve ensaio tem por objetivo analisar certos elementos da vida material egípcia e suas relações com a língua egípcia hieroglífica, na tentativa de contribuir para um melhor entendimento das modificações relativas à imagem de Cleópatra VII (69-30) em seu período de reinado.
Higher education in prehistory and archaeology
Authors: Oosterbeek Luiz
Published: March 2020

The growing divide between sciences and humanities has led, in the last decades, to their global weakening, leading to a pragmatic empire of technological solutions deprived from meaning and global reasoning. In parallel, the source o many current disruptive processes is the incapacity of understanding the implications of the global merger of economies and societies, but also the trend towards segregating new identities and cultural networks. We consider that education and training are key elements in the process of building shared landscapes, i.e., shared convergent perceptions of the territories, and that education in prehistory and archaeology should be structured within this framework. Reflecting on general concerns and perspectives of Humanities education at large, and on specific constraints in Europe and Portugal, we argue that the specific relevance of archaeology within a programme for humanities concerns its expertise in assessing adaptation mechanisms, economy-environment balances, techniques and technology, as well as its interdisciplinary approach, going beyond humanities and involving social and natural sciences. The text concludes by presenting the structure and strategy of the Master programme in Prehistoric Archaeology and Rock Art, as part of a wider programme of archaeology and cultural heritage education at the Polytechnic Institute of Tomar.
El efecto faro del salario mínimo en la estructura salarial: evidencias para México
Authors: Campos Vázquez Raymundo Miguel , Rodas Milián James Alexis
Published: March 2020

Esta investigación analiza los incrementos del salario mínimo en México para 2012 y 2015 con el propósito de identificar sus efectos en la estructura del ingreso laboral y el empleo. Los datos usados provienen de los registros administrativos del IMSS de 2000 a 2018 y, por lo tanto, el estudio se restringe al sector formal de la economía. Esos cambios representan un experimento natural, pues afectaron únicamente ciertos municipios. Adicionalmente, empleamos el método de control sintético para balancear características entre municipios tratados y controles. Los resultados indican que el salario mínimo es relevante para la parte baja de la distribución. Primero, los aumentos del salario mínimo se ven reflejados prácticamente uno a uno en los primeros cinco cuantiles de la distribución. Segundo, al comparar zonas tratadas con control se observa que el salario mínimo tiene un efecto en la estructura salarial, en promedio, hasta el cuantil 10 de la distribución. Finalmente, no se observa un efecto del salario mínimo sobre el empleo en el momento de las intervenciones de 2012 y 2015. Se discute de forma preliminar el efecto faro del incremento del salario mínimo en 2019.