bluuebunny/crossref_metadata_2025 huggingface dataset:
A Local Approach to Parameter Space Reduction for Regression and Classification Tasks
Authors: Romor Francesco , Tezzele Marco , Rozza Gianluigi
Published: May 2024

Parameter space reduction has been proved to be a crucial tool to speed-up the execution of many numerical tasks such as optimization, inverse problems, sensitivity analysis, and surrogate models’ design, especially when in presence of high-dimensional parametrized systems. In this work we propose a new method called local active subspaces (LAS), which explores the synergies of active subspaces with supervised clustering techniques in order to carry out a more efficient dimension reduction in the parameter space. The clustering is performed without losing the input–output relations by introducing a distance metric induced by the global active subspace. We present two possible clustering algorithms: K-medoids and a hierarchical top–down approach, which is able to impose a variety of subdivision criteria specifically tailored for parameter space reduction tasks. This method is particularly useful for the community working on surrogate modelling. Frequently, the parameter space presents subdomains where the objective function of interest varies less on average along different directions. So, it could be approximated more accurately if restricted to those subdomains and studied separately. We tested the new method over several numerical experiments of increasing complexity, we show how to deal with vectorial outputs, and how to classify the different regions with respect to the LAS dimension. Employing this classification technique as a preprocessing step in the parameter space, or output space in case of vectorial outputs, brings remarkable results for the purpose of surrogate modelling.
Scale Dependence of Distributions of Hotspots
Authors: Wilkinson Michael , Veytsman Boris
Published: May 2024

We consider a random field $$\phi ({\textbf{r}})$$

ϕ
(
r
)

in d dimensions which is largely concentrated around small ‘hotspots’, with ‘weights’, $$w_i$$

w
i

. These weights may have a very broad distribution, such that their mean does not exist, or is dominated by unusually large values, thus not being a useful estimate. In such cases, the median $${\overline{W}}$$

W
¯

of the total weight W in a region of size R is an informative characterisation of the weights. We define the function F by $$\ln {\overline{W}}=F(\ln R)$$

ln

W
¯

=
F

(
ln
R
)

. If $$F'(x)>d$$

F
′

(
x
)

>
d

, the distribution of hotspots is dominated by the largest weights. In the case where $$F'(x)-d$$

F
′

(
x
)

-
d

approaches a constant positive value when $$R\rightarrow \infty $$

R
→
∞

, the hotspots distribution has a type of scale-invariance which is different from that of fractal sets, and which we term ultradimensional. The form of the function F(x) is determined for a model of diffusion in a random potential.
Experimental and numerical mechanical characterisation of additively manufactured polymeric lattice structures under uniaxial tensile load
Authors: Bruson Danilo , Iuliano Luca , Galati Manuela
Published: May 2024

Additive manufacturing enables the production of lighter, more robust components with intricate features like lattice structures. However, since the mechanical behaviour of lattice structures is not fully characterized, the application of such potential is limited today. The challenge with lattice structures tensile tests is defining a suitable design that fits the standard requirements and process characteristics. In the polymeric powder bed fusion process, the problem is to produce powder-free geometries and to avoid stress concentrations zones, adapting the specimen accordingly. In this regard, numerical simulation may provide insightful information and support the analysis of the deformation mechanisms. This paper analyses a new tensile sample for lattice structures using finite element analysis. The sample is designed following the EN ISO 527 standard prescriptions. An area with a controlled gradation of the lattice relative density is designed to ensure both powder-free voids and fracture localization within the lattice specimen gauge length. Experimental tests are performed to validate the numerical results using a modified body cubic centred topology with two different strut diameters. The specimens are produced in polyamide by powder bed AM process. Due to the complexity of the lattice design, a digital image correlation is used to compute the full range of strains at the macroscopic level. Experimental and numerical strain maps results showed a good agreement. The recorded deviation was attributed to the process-induced defect, such as the geometrical accuracy that, if compensated, boosted the capability of the numerical model to predict the mechanical behaviour of the lattice structure.
ACRE, a class of AP2/ERF transcription factors, activates the expression of sweet potato ß-amylase and sporamin genes through the sugar-responsible element CMSRE-1
Authors: Maeo Kenichiro , Nakaya Yuki , Mitsuda Nobutaka , Ishiguro Sumie
Published: May 2024

Sugars, synthesized by photosynthesis in source organs, are loaded and utilized as an energy source and carbon skeleton in sink organs, and also known to be important signal molecules regulating gene expression in higher plants. The expression of genes coding for sporamin and β-amylase, the two most abundant proteins in storage roots of sweet potato, is coordinately induced by sugars. We previously reported on the identification of the carbohydrate metabolic signal-responsible element-1 (CMSRE-1) essential for the sugar-responsible expression of two genes. However, transcription factors that bind to this sequence have not been identified. In this study, we performed yeast one-hybrid screening using the sugar-responsible minimal promoter region of the ß-amylase gene as bait and a library composed only transcription factor cDNAs of Arabidopsis. Two clones, named Activator protein binding to CMSRE-1 (ACRE), encoding AP2/ERF transcription factors were isolated. ACRE showed transactivation activity of the sugar-responsible minimal promoter in a CMSRE-1-dependent manner in Arabidopsis protoplasts. Electric mobility shift assay (EMSA) using recombinant proteins and transient co-expression assay in Arabidopsis protoplasts revealed that ACRE could actually act to the CMSRE-1. Among the DEHYDRATION -RESPONSIVE ELEMENT BINDING FACTOR (DREB) subfamily, almost all homologs including ACRE, could act on the DRE, while only three ACREs could act to the CMSRE-1. Moreover, ACRE-homologs of Japanese morning glory also have the same property of DNA-binding preference and transactivation activity through the CMSRE-1. These findings suggested that ACRE plays an important role in the mechanism regulating the sugar-responsible gene expression through the CMSRE-1 conserved across plant species.
The Influence of Extended Reality on Climate Change Education
Authors: Newton Mark H. , Annetta Leonard A.
Published: May 2024

Climate change is a nuanced global issue with a scope that is often difficult to fully appreciate. This study examined an undergraduate course focused on the impacts and responses to climate change on the Outer Banks of North Carolina, USA. The course utilized a socioscientific issues (SSI) approach to examine global climate change in a local context that allowed for a deeper understanding of the inequitable impacts on humans and the environment. As part of the class, students were immersed in a 6-day field experience in the Outer Banks to investigate the challenges facing the barrier islands where they visited five sites and used augmented reality (AR) to learn about the impact of climate change at those respected locations. After each experience, the course instructors debriefed with the students to help make sense of the experiences and promote deeper understanding of the issue. Four weeks later, the class immersed in virtual reality (VR) to revisit the same five sites using the same information provided in the AR. Using a constant comparative and inductive analyzes using keywords in context, results suggest both AR and VR enhanced learning experiences. Findings indicated that the students generally felt that the VR experience was a suitable alternative, with the caveat that it cannot replace being immersed in the location, that both technologies increased their engagement, and increased their learning. Conversely, some students reported that the technology impeded their learning.
The Crucial Nexus of Microplastics on Ecosystem and Climate Change: Types, Source, Impacts, and Transport
Authors: Ratnasari Anisa , Zainiyah Isti Faizati , Hadibarata Tony , Yan Lau Yu , Sharma Sunny , Thakur Samrendra Singh
Published: May 2024

Microplastics (MPs) pollution is a significant concern within environmental degradation, prevalent across various ecosystems, including aquatic and terrestrial environments. Industries such as agriculture, laundry, tourism, personal care products, and cosmetics primarily contribute to MP pollution in both soil and aquatic ecosystems. The ingestion of MPs by marine and terrestrial organisms, followed by their subsequent transfer along the food chain, has been extensively documented. Additionally, the presence of MPs in the environment has potentially exacerbated climate change dynamics. Notably, studies have revealed that MPs in soils exhibit interactive effects on nitrogen and carbon cycles, leading to increased emissions of N2O by up to 37.5% and CO2 by up to 92%. Despite numerous studies highlighting MPs' abundance and adverse impacts on terrestrial and aquatic ecosystems, there remains a significant knowledge gap concerning their correlation with climate change and their broader implications for human and environmental health. While previous research has shed light on the ecological consequences of MPs, a comprehensive review addressing the correlation between MPs abundance in terrestrial and aquatic ecosystems and their impact on climate change and human health has yet to be presented. The present study offers a comprehensive overview of various types of MPs, their sources, impacts, and transport pathways under changing climatic conditions. The findings of this study are anticipated to contribute towards mitigating the transport of MPs within ecosystems, thereby minimizing ecological impacts and their associated greenhouse gas emissions.
Efficacy and Safety of Paragastric Neural Blockade in Controlling Pain, Nausea, and Vomiting After Sleeve Gastrectomy: A Randomized Controlled Trial
Authors: Katar Mehmet Kağan , Turan Umut Fırat
Published: May 2024

Background

There are difficulties in controlling the symptoms of pain, nausea, and vomiting after laparoscopic sleeve gastrectomy (LSG). This study aimed to evaluate the efficacy and safety of PGNB on pain and nausea and vomiting in the early postoperative period in patients who underwent LSG.

Methods

In this prospective, randomized, controlled, double-blind study, the patients were divided into two equally formed groups: patients who underwent PGNB after LSG and the control group. Postoperative pain symptoms were evaluated using the visual analog scale (VAS) scores, and nausea and vomiting symptoms were evaluated using the postoperative nausea and vomiting (PONV) scores.

Results

The study was completed with 90 patients, 45 patients in each group. The VAS scores measured at postoperative hours 1, 6, and 12 were statistically significantly lower in the PGNB group. There was no significant difference between the two groups in terms of the 24th hour VAS scores. The mean PONV scores of the PGNB and control groups were 0.47 ± 0.89 and 1.67 ± 1.95, respectively, revealing a significantly higher value for the controls. The mean time to first mobilization in the postoperative period was significantly shorter in the PGNB group. Upon the evaluation of patient satisfaction, it was determined that the satisfaction score of the PGNB group was significantly higher.

Conclusions

PGNB is an effective and safe method for managing pain, nausea, and vomiting that occur in the early period after LSG.

Graphical Abstract
Role of Hypoxia in Mesenchymal Stem Cells from Dental Pulp: Influence, Mechanism and Application
Authors: Ma Muyuan
Published: May 2024

Mesenchymal stem cells (MSCs) from dental pulp (DP-MSCs), which include dental pulp stem cells (DPSCs) isolated from permanent teeth and stem cells from human exfoliated deciduous teeth (SHED), have emerged as highly promising cell sources for tissue regeneration, due to their high proliferative rate, multi-lineage differentiation capability and non-invasive accessibility. DP-MSCs also exert extensive paracrine effects through the release of extracellular vesicles (EVs) and multiple trophic factors. To be noted, the microenvironment, commonly referred to as the stem cell niche, plays a crucial role in shaping the functionality and therapeutic effects of DP-MSCs, within which hypoxia has garnered considerable attention. Extensive research has demonstrated that hypoxic conditions profoundly impact DP-MSCs. Specifically, hypoxia promotes DP-MSC proliferation, survival, stemness, migration, and pro-angiogenic potential while modulating their multi-lineage differentiation capacity. Furthermore, hypoxia stimulates the paracrine activities of DP-MSCs, leading to an increased production of EVs and soluble factors. Considering these findings, hypoxia preconditioning has emerged as a promising approach to enhance the therapeutic potential of DP-MSCs. In this comprehensive review, we provide a systematic overview of the influence of hypoxia on DP-MSCs, shedding light on the underlying mechanisms involved. Moreover, we also discuss the potential applications of hypoxia-preconditioned DP-MSCs or their secretome in tissue regeneration. Additionally, we delve into the methodologies employed to simulate hypoxic environments. This review aims to promote a comprehensive and systematic understanding of the hypoxia-induced effects on DP-MSCs and facilitate the refinement of regenerative therapeutic strategies based on DP-MSCs.

Graphical Abstract
LncRNA MEG3 Restrains Hepatic Lipogenesis via the FOXO1 Signaling Pathway in HepG2 Cells
Authors: Meng Xiangyu , Long Mei , Yue Nanxi , Li Quan , Chen Jia , Zhao Hongye , Deng Wei
Published: May 2024

Nonalcoholic fatty liver disease (NAFLD) become a main public health concern, and is characterized by lipid accumulation in the hepatocytes. We found that overexpression of lncRNA MEG3 significantly reduced the expression of FOXO1, ACC1, and FAS, and subsequently decreased the lipid accumulation in HepG2 cells. Moreover, inhibition of lncRNA MEG3 could increase the lipid accumulation and the mRNA and protein levels of FOXO1, ACC1, and FAS. Further study showed that lncRNA MEG3 regulates the lipogenesis process by inhibiting the entry of FOXO1 into the nucleus translocation. Our study demonstrated that lncRNA MEG3 regulates de novo lipogenesis by decreasing the expression and nucleus translocation of FOXO1 in HepG2 cells, suggesting that lncRNA MEG3 could be a promising therapeutic target in lipid metabolic disorders.
HAX1-Overexpression Augments Cardioprotective Efficacy of Stem Cell-Based Therapy Through Mediating Hippo-Yap Signaling
Authors: Cai Wen-Feng , Jiang Lin , Liang Jialiang , Dutta Suchandrima , Huang Wei , He Xingyu , Wu Zhichao , Paul Christian , Gao Xiang , Xu Meifeng , Kanisicak Onur , Zheng Junmeng , Wang Yigang
Published: May 2024

Although stem/progenitor cell therapy shows potential for myocardial infarction repair, enhancing the therapeutic efficacy could be achieved through additional genetic modifications. HCLS1-associated protein X-1 (HAX1) has been identified as a versatile modulator responsible for cardio-protective signaling, while its role in regulating stem cell survival and functionality remains unknown. In this study, we investigated whether HAX1 can augment the protective potential of Sca1+ cardiac stromal cells (CSCs) for myocardial injury. The overexpression of HAX1 significantly increased cell proliferation and conferred enhanced resistance to hypoxia-induced cell death in CSCs. Mechanistically, HAX1 can interact with Mst1 (a prominent conductor of Hippo signal transduction) and inhibit its kinase activity for protein phosphorylation. This inhibition led to enhanced nuclear translocation of Yes-associated protein (YAP) and activation of downstream therapeutic-related genes. Notably, HAX1 overexpression significantly increased the pro-angiogenic potential of CSCs, as demonstrated by elevated expression of vascular endothelial growth factors. Importantly, implantation of HAX1-overexpressing CSCs promoted neovascularization, protected against functional deterioration, and ameliorated cardiac fibrosis in ischemic mouse hearts. In conclusion, HAX1 emerges as a valuable and efficient inducer for enhancing the effectiveness of cardiac stem or progenitor cell therapeutics.

Graphical Abstract
MD-DATA: the legacy of the ABC Consortium
Authors: Hospital Adam , Orozco Modesto
Published: May 2024

The ABC Consortium has been generating nucleic-acids MD trajectories for more than 20 years. This brief comment highlights the importance of this data for the field, which triggered a number of critical studies, including force-field parameterization and development of new coarse-grained and mesoscopic models. With the world entering into a new data-driven era led by artificial intelligence, where data is becoming more essential than ever, the ABC initiative is leading the way for nucleic acid flexibility.
Crosstalk between cancer cells and macrophages promotes OSCC cell migration and invasion through a CXCL1/EGF positive feedback loop
Authors: Huang Wei , Jiang Mingjing , Lin Ying , Qi Ying , Li Bo
Published: May 2024

Background

C-X-C motif chemokine ligand 1 (CXCL1) and epithelial growth factor (EGF) are highly secreted by oral squamous cell carcinoma (OSCC) cells and tumor-associated macrophages, respectively. Recent studies have shown that there is intricate "cross-talk" between OSCC cells and macrophages. However, the underlying mechanisms are still poorly elucidated.

Methods

The expression of CXCL1 was detected by immunohistochemistry in OSCC clinical samples. CXCL1 levels were evaluated by RT‒PCR and ELISA in an OSCC cell line and a normal epithelial cell line. The expression of EGF was determined by RT‒PCR and ELISA. The effect of EGF on the proliferation of OSCC cells was evaluated by CCK-8 and colony formation assays. The effect of EGF on the migration and invasion ability and epithelial-mesenchymal transition (EMT) of OSCC cells was determined by wound healing, Transwell, RT‒PCR, Western blot and immunofluorescence assays. The polarization of macrophages was evaluated by RT‒PCR and flow cytometry. Western blotting was used to study the molecular mechanism in OSCC.

Results

The expression of C-X-C motif chemokine ligand 1 (CXCL1) was higher in the OSCC cell line (Cal27) than in immortalized human keratinocytes (Hacat cells). CXCL1 derived from Cal27 cells upregulates the expression of epithelial growth factor (EGF) in macrophages. Paracrine stimulation mediated by EGF further facilitates the epithelial-mesenchymal transition (EMT) of Cal27 cells and initiates the upregulation of CXCL1 in a positive feedback-manner. Mechanistically, EGF signaling-induced OSCC cell invasion and migration can be ascribed to the activation of NF-κB signaling mediated by the epithelial growth factor receptor (EGFR), as determined by western blotting.

Conclusions

OSCC cell-derived CXCL1 can stimulate the M2 polarization of macrophages and the secretion of EGF. Moreover, EGF significantly activates NF-κB signaling and promotes the migration and invasion of OSCC cells in a paracrine manner. A positive feedback loop between OSCC cells and macrophages was formed, contributing to the promotion of OSCC progression.
Characterization of HIV variants from paired Cerebrospinal fluid and Plasma samples in primary microglia and CD4+ T-cells
Authors: Gumbs Stephanie B. H. , Stam Arjen J. , Mudrikova Tania , Schipper Pauline J. , Hoepelman Andy I. M. , van Ham Petra M. , Borst Anne L. , Hofstra LMarije , Gharu Lavina , van Wyk Stephanie , Wilkinson Eduan , de Witte Lot D. , Wensing Annemarie M. J. , Nijhuis Monique
Published: May 2024

Despite antiretroviral therapy (ART), HIV persistence in the central nervous system (CNS) continues to cause a range of cognitive impairments in people living with HIV (PLWH). Upon disease progression, transmigrating CCR5-using T-cell tropic viruses are hypothesized to evolve into macrophage-tropic viruses in the CNS that can efficiently infect low CD4-expressing cells, such as microglia. We examined HIV-1 RNA concentration, co-receptor usage, and CSF compartmentalization in paired CSF and blood samples from 19 adults not on treatment. Full-length envelope CSF- and plasma-derived reporter viruses were generated from 3 subjects and phenotypically characterized in human primary CD4+ T-cells and primary microglia. Median HIV RNA levels were higher in plasma than in CSF (5.01 vs. 4.12 log10 cp/mL; p = 0.004), and coreceptor usage was mostly concordant for CCR5 across the paired samples (n = 17). Genetically compartmentalized CSF viral populations were detected in 2 subjects, one with and one without neurological symptoms. All viral clones could replicate in T-cells (R5 T cell-tropic). In addition, 3 CSF and 1 plasma patient-derived viral clones also had the capacity to replicate in microglia/macrophages and, therefore have an intermediate macrophage tropic phenotype. Overall, with this study, we demonstrate that in a subset of PLWH, plasma-derived viruses undergo genetic and phenotypic evolution within the CNS, indicating viral infection and replication in CNS cells. It remains to be studied whether the intermediate macrophage-tropic phenotype observed in primary microglia represents a midpoint in the evolution towards a macrophage-tropic phenotype that can efficiently replicate in microglial cells and propagate viral infection in the CNS.
The Association between Circadian Syndrome and Frailty in US adults: a cross-sectional study of NHANES Data from 2007 to 2018
Authors: Sun Lirong , Huo XingWei , Jia Shanshan , Chen Xiaoping
Published: May 2024

Purpose

Frailty and Circadian Syndrome (CircS) are prevalent among the elderly, yet the link between them remains underexplored. This study aims to examine the association between CircS and frailty, particularly focusing on the impact of various CircS components on frailty.

Materials and methods

We conducted a cross-sectional analysis using data from the National Health and Nutrition Examination Survey (NHANES) spanning 2007 to 2018. The 49-item Frailty Index (FI) was employed to assess frailty. To understand the prevalence of CircS in relation to frailty, we applied three multivariate logistic regression models. Additionally, subgroup and interaction analyses were performed to investigate potential modifying factors.

Results

The study included 8,569 participants. In fully adjusted models, individuals with CircS showed a significantly higher risk of frailty compared to those without CircS (Odds Ratio [OR] = 2.18, 95% Confidence Interval [CI]: 1.91–2.49, p < 0.001). A trend of increasing frailty risk with greater CircS component was observed (trend test p < 0.001). Age (p = 0.01) and race (p = 0.02) interactions notably influenced this association, although the direction of effect was consistent across subgroups. Sensitivity analysis further confirmed the strength of this relationship.

Conclusion

This study identifies a strong positive correlation between CircS and frailty in the elderly. The risk of frailty escalates with an increasing number of CircS components. These findings highlight the intricate interplay between circadian syndrome and frailty in older adults, offering valuable insights for developing targeted prevention and intervention strategies.
Effect of social participation on the trajectories of activities of daily living disability among community-dwelling older adults: a 7-year community-based cohort
Authors: Wen Cai , Sun Shuangyuan , Huang Limei , Guo Yanfei , Shi Yan , Qi Shige , Ding Guomei , Wen Zhiqin , Wang Jiaqi , Ruan Ye , Zhao Qi
Published: May 2024

Introduction

Studies examining the effects of social participation on activities of daily living (ADL) disability are still scarce.

Aim

To assess the reciprocal relationship between ADL disability trajectories and social participation among older Chinese people aged ≥ 60 years.

Methods

This study included 2976 participants aged ≥ 60 years in six waves of a community-based survey from 2015 to 2022. Basic activities of daily living (BADL) and instrumental activities of daily living (IADL) were used to assess the ADL disability in each survey. Social participation was assessed by involvement in four social activities and an extensive social participation score. Group-based trajectory modeling was used to identify potential heterogeneity in longitudinal changes over 7 years and explore associations between baseline predictors of group membership and these trajectories.

Results

Two BADL disability trajectories were identified: stable (94.8%) and increase (5.2%). Additionally, three IADL disability trajectories were distinguished: stable (73.2%), moderate (20.2%), and increase (6.6%). After controlling for the potential covariates, each point increase in the extensive social participation score correlated with a 17% decrease in the odds of older individuals belonging to the increase BADL trajectory group (OR = 0.83, 95% CI = 0.68–1.00). For IADL, it decreased the odds of being assigned to the moderate trajectory group by 16% (OR = 0.84, 95% CI = 0.75–0.95) and to the increase trajectory group by 23% (OR = 0.77, 95% CI = 0.64–0.93).

Conclusions

Higher levels of social participation among older individuals were more likely to be classified as stable trajectories in both BADL and IADL. Increased participation in social activities by community-dwelling elderly adults may promote healthy aging.
Generative AI and Usage in Marketing Classroom
Authors: Ding Min , Dong Songting , Grewal Rajdeep
Published: May 2024

This article examines the role of Generative Artificial Intelligence (GenAI) in the context of marketing education, highlighting its substantial impact on the field. The study is based on an analysis of how GenAI, particularly through the use of Large Language Models (LLMs), functions. We detail the operational mechanisms of LLMs, their training methods, performance across various metrics, and the techniques for engaging with them via prompt engineering. Building on this foundation, we explore popular GenAI platforms and models that are relevant to marketing, focusing on their key features and capabilities. We then assess the practical applications of GenAI in marketing tasks and educational settings, considering its utility in tasks such as providing information, extracting data, generating content, conducting simulations, and performing data analysis. By examining these areas, this paper demonstrates the integral role of GenAI in reshaping both marketing strategies and teaching methodologies and argues for its adoption as a critical resource for forward-thinking marketers and educators.
Implementierung von Maßnahmen zur Optimierung psychischer Belastungen im Kontext Hochschule
Authors: Diebig Mathias , Heming Meike , Angerer Peter
Published: May 2024

Hintergrund

Aufgrund der aktuell sehr großen Anforderungen an wissenschaftliche Beschäftigte in deutschen Hochschulen steigt der Bedarf an Maßnahmen, die helfen, Arbeitsbedingungen in diesem Kontext zu analysieren, zu verändern und zu optimieren. Tatsächlich ist die Umsetzungsquote solcher Maßnahmen im Hochschulkontext aktuell sehr gering, und die Gründe für diese unzureichende Umsetzung sind nur teilweise aufgedeckt.

Ziel der Arbeit

Mittels Ergebnissen aus Interviews und Fallstudien soll ein Einblick in die Praxis geben werden. Es soll aufgezeigt werden, welche psychischen Belastungen im wissenschaftlichen Umfeld als kritisch bewertet werden und welche konkreten Vorgehensweisen zu deren Optimierung sich im Kontext Hochschule eignen.

Material und Methoden

In sieben qualitativen Interviews soll der Stellenwert von Gesundheit, typischen Stressoren bei der Arbeit, Herangehensweisen zur Förderung der Gesundheit der Beschäftigten sowie Wünschen und Erwartungen an Leitungsgremien von Hochschulen erörtert werden. In sechs Fallstudien wird der Fokus auf einzelne wissenschaftliche Einheiten gerichtet und beispielhaft die Durchführung von Vorgehensweisen zur Verbesserung der Arbeitsbedingungen erprobt. Interviews und Fallstudien wurden dokumentiert und qualitativ ausgewertet.

Ergebnisse

Die Ergebnisse zeigen, welche Herangehensweisen zur Gestaltung von Arbeitsbedingungen im Kontext Hochschule eingesetzt werden und mit welchen Herausforderungen und Problemen diese Ansätze verbunden sind. Es zeigt sich auch, dass trotz der hohen Bedeutung von gesundheitlichen Themen in den Einheiten der Bedarf an geeigneten Maßnahmen zur Verbesserung von Arbeitsbedingungen eher gering ist.

Diskussion

Der Beitrag gibt einen Einblick in die organisatorische Praxis. Es soll weitere Forschung angestoßen werden, die dazu beiträgt, dass Maßnahmen zur Optimierung psychischer Belastungen im Kontext Hochschule weiter etabliert werden.
Coupled connectivity in the global complex network: the case of United Kingdom (1880–1925)
Authors: Polo-Martín Bárbara , Ducruet César
Published: May 2024

The main objective of this research is to analyse the connectivity of cities in a coupled network composed of planar (railways) and non-planar (maritime) topologies. It examines the state of the network during the 1880–1925 period, namely in the context of the first globalization wave (1880–1914), when trade and urban development were closely tied to progress in communications systems and steam propulsion especially. Edges represent intercity physical infrastructure on land, and inter-port ship voyages at sea. We tested several hypotheses in terms of inter-network specialisation and urban hierarchies with an application in the United Kingdom. The main results reveal that the networks are highly interdependent, whereas combined centrality is closely associated with city size and urban growth. We discuss the key results in light of network science, spatial science, maritime history, and transport research.
Locating Australian school students in sites of curriculum making: a literature review
Authors: Cairns Rebecca
Published: May 2024

Young people and children are central to conceptualisations of curriculum as a social process, especially in school-based settings. However, students have tended to be on the periphery of education policy development more broadly and curriculum reform more specifically. As a more inclusive approach to engaging students in curriculum consultation processes is beginning to be taken in Australia, it is timely to gauge the extent to which students are being actively engaged as curriculum actors and research participants across the Australian curricular landscape. This article draws on Priestley et al.’s (2021) sites of curriculum making model to frame a systematised literature review of a decade of Australian academic and grey literature for the purpose of identifying the sites and activities in which students are active and/or the focus of research. The review suggests there is a small body of research on curriculum negotiation within school-based nano and micro sites of curriculum making. However, an absence of academic research related to meso and macro curriculum making means we have a limited understanding of the dynamics of the activities, interactions, contestations and power relations that constitute curriculum making in these spaces in relation to students. This article considers some of the reasons for and implications of these trends, including how existing curriculum and student voice scholarship might inform future research. It argues that a better understanding of the possibilities and challenges of student-centred curriculum making activities could assist in moving beyond superficial “consultation” methods, especially during periods of significant curriculum renewal.
Dibble’s Reduction Thesis: Implications for Global Lithic Analysis
Authors: Shott Michael J.
Published: May 2024

Harold Dibble demonstrated the systematic effects of reduction by retouch upon the size and shape of Middle Paleolithic tools. The result was the reduction thesis, with its far-reaching implications for the understanding of Middle Paleolithic assemblage variation that even now are incompletely assimilated. But Dibble’s influence extended beyond the European Paleolithic. Others identified additional reduction methods and measures that complement Dibble’s reduction thesis, and applied analytical concepts and methods consistent with it to industries and assemblages around the world. These developments facilitated comprehensive reduction analysis of archaeological tools and assemblages and their comparison in the abstract despite the great diversity of their time–space contexts. Dibble argued that many assemblages are time-averaged accumulations. In cases from New Zealand to North America, methods he pioneered and that others extended reveal the complex processes by which behavior, tool use, curation, and time interacted to yield those accumulations. We are coming to understand that the record is no mere collection of ethnographic vignettes, instead a body of data that requires macroarchaeological approaches. Archaeology’s pending conceptual revolution in part is a legacy of Dibble’s thought.
Training for Recovery: Impact of Sprint Interval Training on Recovery Dynamics and Aerobic Performance in Kickboxing Athletes
Authors: Hall Andy , Williams Ashley K. , Babraj John
Published: May 2024

Purpose

Recovery within and between rounds is crucial to combat sports performance. We sought to determine whether sprint interval training (SIT) improves recovery dynamics and aerobic performance.

Methods

Eleven male kickboxing athletes (26 ± 5 years; body mass index 25 ± 3 kg/m2) were recruited. Participants were tested three times for VO2peak/time to exhaustion and critical power; baseline, 3 weeks control, 3 weeks of SIT (8 × 10 s lower body sprints followed by a maximum of 10 min recovery before completing 8 × 10 s upper body sprints). During SIT session 1 and 9 continuous gas analysis was performed.

Results

There was a significant reduction in recovery time between lower and upper body sprints with training (session 1: 441 ± 150 s; session 9: 268 ± 10 s; P < 0.01; d = 2.77) and change in oxygen off-kinetics amplitude (session1: 3.0 ± 0.7 L/min, session 9: 3.6 ± 1.0 L/min; P < 0.05; d = − 1.77), VO2 end (session 1: 0.59 ± 0.19 L/min, session 9: 0.81 ± 0.21 L/min; P < 0.05, d = − 0.90), time constant (session 1: 81 ± 21 s; session 9: 60 ± 11 s; P < 0.05; d = 1.03). Following training there was a significant improvement in critical power (P < 0.05; η2p = 0.72) time to exhaustion (P < 0.05; η2p = 0.30) but not VO2peak (P > 0.05).

Conclusion

SIT improves recovery time associated and aerobic performance associated with improved oxygen off-kinetics. Therefore, training needs to focus on improving oxygen off-kinetics to enhance combat performance.
Does corporate governance moderate the impact of earnings management on capital structure of the listed corporations on Palestine and Amman Bourses
Authors: Abualhassan Shms Alduha , Nour Abdulnaser I. , Atout Sameh , Daraghma Zahran , Jebreen Kamel , Alzebdieh Rami Moh’d
Published: May 2024

The purpose of this research is to investigate the moderating role of corporate governance on the relationship between earnings management and debt level in capital structure. The paper used a hypothesis-testing research approach to gather data from the annual reports of 13 industrial companies listed on Palestine Exchange and 25 Jordanian companies listed on Amman Stock Exchange from 2013 to 2020. Descriptive and inferential statistics were employed, along with correlation analysis to evaluate linear relationships between variables. The fixed and random effect regressions were utilized to develop the research model. In the case of Palestinian manufacturing firms, the results revealed that Earnings Management (EM) had a significant negative impact on debt level. According to the moderating role of Corporate Governance (CG), larger boards and the existence of female members on the board of directors causes an increase in the high-leverage impact of EM, whereas CEO duality mitigates the high-leverage impact. However, in the case of Jordanian manufacturing firms, EM showed an insignificant impact on debt level. Regarding the moderating role of CG, it was proved that the presence of female members on the board of directors increased the firm’s reliance on debt financing as a result of EM practices, while institutional investors mitigate the effect of EM on debt financing, leading to a decrease in reliance on debt. The findings of this research are suitable for the regulators while formulating policies on the Corporate Governance and the Impact of Earnings Management on Capital Structure. These findings have guided the policymakers that they should enhance their focus on Palestine and Jordan companies to test Corporate Governance Moderates the Impact of Earnings Management on Capital Structure. This study is also helpful for the new researcher while investigating this area in the future.
Near-infrared two-photon absorption and excited state dynamics of a fluorescent diarylethene derivative
Authors: Sotome Hikaru , Nagasaka Tatsuhiro , Konishi Tatsuki , Kamada Kenji , Morimoto Masakazu , Irie Masahiro , Miyasaka Hiroshi
Published: May 2024

Near-infrared two-photon absorption and excited state dynamics of a fluorescent diarylethene (fDAE) derivative were investigated by time-resolved absorption and fluorescence spectroscopies. Prescreening with quantum chemical calculation predicted that a derivative with methylthienyl groups (mt-fDAE) in the closed-ring isomer has a two-photon absorption cross-section larger than 1000 GM, which was experimentally verified by Z-scan measurements and excitation power dependence in transient absorption. Comparison of transient absorption spectra under one-photon and simultaneous two-photon excitation conditions revealed that the closed-ring isomer of mt-fDAE populated into higher excited states deactivates following three pathways on a timescale of ca. 200 fs: (i) the cycloreversion reaction more efficient than that by the one-photon process, (ii) internal conversion into the S1 state, and (iii) relaxation into a lower state (S1’ state) different from the S1 state. Time-resolved fluorescence measurements demonstrated that this S1’ state is relaxed to the S1 state with the large emission probability. These findings obtained in the present work contribute to extension of the ON–OFF switching capability of fDAE to the biological window and application to super-resolution fluorescence imaging in a two-photon manner.

Graphical Abstract
A boundary element analysis of quasi-potential inviscid incompressible flow in multiply connected airfoil wing
Authors: Fahmy Mohamed Abdelsabour , Alzubaidi Mohammed Hassan M.
Published: May 2024

The quasi-potential flow in a doubly linked airfoil wing with a sharp trailing edge can be solved using a high-order boundary-element method (BEM). A bicubic Hermite spline interpolation is used to express the unknown, with node derivatives given by finite difference method. The revolutionary traits apply to bleeding-edge settings; specifically, challenges relating to the three-dimensional problem of multiply connected domains are investigated. Numerical validation examples were utilized to assess the implemented BEM approach.
Maternal health care for women with disabilities: perspectives of health professionals in Ghana
Authors: Obeng Bernard , Asante Emmanuel Agyemang , Agyemang Eric , Aryee Clement
Published: May 2024

In many developing countries, like Ghana, persons with disability face a lot of marginalisation and discrimination. Despite WHO’s assertion that disabled persons deserve equal access to healthcare, disparities remain. Health professionals play a pivotal role in reducing maternal mortality. Yet few studies engage professionals to understand these perceptions and how they shape service provision. This highlights the need for research investigating health professionals’ perceptions of delivering maternal healthcare to women with disabilities in Ghana. With the aid of a qualitative approach, this study explored the perceptions of healthcare professionals on disabled women who sought maternal healthcare in Ghana. Data was gathered from 25 healthcare workers, consisting of midwives and doctors. The thematic analysis uncovered two contrasting themes—positive perceptions highlighting the determination and strength of disabled women and negative perceptions shaped by cultural biases questioning the need for disabled women to become pregnant. Bridging this gap necessitates comprehensive training, patient-centred collaborative approaches, and anti-discrimination policies to establish an equitable Ghanaian healthcare system that safeguards the reproductive rights and options of pregnant and disabled women. Dedication from all stakeholders is imperative to ensure inclusiveness and fair treatment.
“The Dead Have Been Awakened in the Service of the Living”: Activist Community-Engaged Archaeology in Charleston, South Carolina
Authors: Gilmore Joanna K. , Ofunniyin Ajani Ade , Oubré La'Sheia O. , Fleskes Raquel E. , Schurr Theodore G.
Published: May 2024

In 2013, 36 Ancestors of African descent were identified in an unmarked eighteenth-century burial ground during construction in Charleston, South Carolina. The site, later referred to as the Anson Street African Burial Ground, was buried beneath the growing city and forgotten in the centuries that followed. The ethical treatment of these ancestral remains was of paramount importance to our community. Historically, narratives relating to the lives of African descendant people in Charleston have been inadequately documented and shared. For these reasons, we engaged the local African American community in a multifaceted memorialization process. Together, we sought to sensitively ensure that the Ancestors’ identities and lives were fully explored according to the collective descendant community's wishes. To this end, we involved the community in researching and celebrating the Ancestors’ lives through arts and education programs and analyzed their and community members’ DNA to elucidate their ancestry. Our engagement initiatives increased access for all ages to archaeological, historical, and genetic research and encouraged active participation in the design of a permanent memorial. The Anson Street African Burial Ground Project provides a successful example of community-engaged activist archaeology focused on honoring the Ancestors and their descendants.
Hilbert transform view of water-wave theory
Authors: Krechetnikov R.
Published: May 2024

A general rethinking of the mathematical foundations of water surface waves from the perspective of the Hilbert transform uncovers shortcomings of the standard multiple-scale approach as well as elucidates the interplay of non-local and dispersive effects. Application of the Hilbert transforms to planar and cylindrical settings allows us to deduce new weakly nonlinear models, including an alternative to Zakharov's equation and an envelope equation for cylindrical waves on deep water, as well as to highlight the crucial differences between these geometries.
To Hedge or Not to Hedge: Scientific Claims and Public Justification
Authors: Ward Zina B. , Creel Kathleen A.
Published: May 2024

Scientific hedges are communicative devices used to qualify and weaken scientific claims. Gregor Betz has argued—unconvincingly, we think—that hedging can rescue the value-free ideal for science. Nevertheless, Betz is onto something when he suggests there are political principles that recommend scientists hedge public-facing claims. In this article, we recast this suggestion using the notion of public justification. We formulate and reject a Rawlsian argument that locates the justification for hedging in its ability to forge consensus. On our alternative proposal, hedging is often justified because it renders scientific claims as publicly accessible reasons.
Corruption and Co-Optation in Autocracy: Evidence from Russia
Authors: SZAKONYI DAVID
Published: May 2024

Do corrupt officials govern differently in elected office? This article develops a theoretical framework and analyzes new data from financial disclosures to estimate the governing costs of corruption. First, I uncover substantial hidden wealth held by roughly one quarter of the legislators in the Russian Duma; these “kompromat deputies” are vulnerable to damaging information being used against them by the regime. Analyzing their behavior in office, I find that these deputies are less active and more absent members of parliament. When called to vote, kompromat deputies from the opposition also more eagerly support the regime’s political agenda. Finally, kompromat deputies are less likely to win reelection, suggesting that they have shorter time horizons as well as that parties have incentives to rotate them out. Autocrats permit and then monitor corruption in order to co-opt potential challengers, who in turn trade loyalty to the regime in exchange for opportunities to self-enrich.
It's time for Africa – hidden diversity of the Aphidius colemani species group (Hymenoptera, Braconidae, Aphidiinae) south of the Sahara
Authors: Čkrkić Jelisaveta , Petrović Andjeljko , Kocić Korana , Mitrovski-Bogdanović Ana , Tomanović Željko
Published: May 2024

Aphidius colemani is an important biological control agent, used in greenhouses and open fields against aphid pests. Despite this economical importance, A. colemani, along with A. transcaspicus and A. platensis, has gone through a complex taxonomical history. The three species have only recently gained status as separate species again, comprising the morphologically defined Aphidius colemani species group. Other than sporadic records probably as a consequence of escape from greenhouses, the A. colemani species group members prefer warmer regions and there are numerous records from South America, Southern Europe and Asia. Based on slide-mounted material collected in the period 1964–2001 in Africa, we describe five new species belonging to this group, and report A. colemani, A. transcaspicus and A. platensis from several African countries. This data opens questions about the origin of the group and presents potential for the diversification of biological control agents against aphid pests.
Hanging by a Thread: The National Memorial for Peace and Justice and the Complexities of Memorializing and Mourning Lynching in America
Authors: BLAINEY MIA
Published: May 2024

BrANCH's Harriet Tubman essay prize seeks to reward the best undergraduate essay or research project by Black, Asian, or other minority ethnic students based in the UK. The prize is generously cosponsored by the Royal Historical Society.
The political economy of urban party switching in African elections: Evidence from Zambia
Authors: Siachiwena Hangala , Wahman Michael
Published: May 2024

Zambia experienced its third electoral turnover in the 2021 election. While the ruling Patriotic Front (PF) lost votes across the territory, the electoral collapse in urban Zambia was particularly remarkable. This paper argues that economic performance voting can explain urban party switching in Zambia. The argument is supported by a unique panel survey of Zambian voters in the period 2019–2022. We show that urban voters were more likely to desert the PF, even when we control for ethnicity. We also show that they were more likely to evaluate the economy poorly and more likely to change their electoral preferences in view of such poor economic evaluation. Our results stress that African elections should not be understood as static expressions of stable political cleavages but may function as real opportunities for political accountability. However, the extent to which voters are willing to re-evaluate their vote choice varies across space.