bluuebunny/crossref_metadata_2025 huggingface dataset:
Combination of electrical submersible pump and gaslift for offshore wells in Vietnam
Authors:   Faculty of Geology & Petroleum Engineering, Hochiminh City University of Technology, VNU-HCM, Vietnam, Phạm Sơn Tùng , Trần Đình Hậu ,   Faculty of Geology & Petroleum Engineering, Hochiminh City University of Technology, VNU-HCM, Vietnam, Trương Lê Hiếu Nghĩa ,   PetroVietnam Exploration Production Corporation – PVEP POC, Vietnam
Published: March 2023

Artificial lifting systems have been in use for a long time all over the world. Artificial lifting systems act on the fluid column in the tubing to support and push the fluid column to the surface. Through the use of each method separately, we can analyze the advantages and disadvantages, the impacts and limitations of each method on the fluid column in the tubing, from which we can design an artificial lifting system to optimize production. In addition, practical limitations also have negative effects on the system such as injection pressure and injection gas available causing a restriction on the production when using GL, or pump horsepower and power supply causes limitations when using ESP. For those reasons, we can combine the two methods together to create an efficient production system. In this study paper, the effects on the fluid column in the tubing are analyzed when combining two methods, which are the GL method and the ESP method. Each method causes a different effect on the fluid column. That difference in this paper will be analyzed based on the "equivalent depth" method, which will represent the pressure points at each position in the tubing when using each artificial lifting method. In addition, we will use the "nodal analysis" method to find out the actual product of the production system when using a combination of the two methods. Based on the analysis of two methods "equivalent depth" and "nodal analysis", it has been proved that it is feasible and appropriate to combine the two methods GL and ESP for many special production wells that can be used for specific fields, such as deep wells. The systems of this combination can be used for wells for long time with respect to the pressure drop over time.
Determination of skin factor using two different methods: pressure transient analysis and production data analysis
Authors:   Faculty of Geology & Petroleum Engineering, Hochiminh City University of Technology-VNU-HCM, Vietnam, Phạm Sơn Tùng , Võ Hoàng Thọ ,   Faculty of Geology & Petroleum Engineering, Hochiminh City University of Technology-VNU-HCM, Vietnam, Trương Lê Hiếu Nghĩa ,   PetroVietnam Exploration Production Corporation – PVEP POC, Vietnam
Published: March 2023

Skin factor is an important parameter in petroleum production engineering. Skin factor is used to optimize production, petroleum production analyzing and forecast, and help determine the Inflow Performance Relationship curve. Skin factor are usually determined by Pressure Transient Analysis which certainly causes the temporary close of the production, hence it also leads to the financial loss because of non-productive time of the well. In order to avoid this unwanted situation, this paper presented another method to determine skin factor using production data analysis. A workflow to calculate the skin factor is proposed for two different methods. The first method is based on production data analysis and the second one is based of the Pressure Transient Analysis. A process to estimate the skin factor by the Pressure Transient Analysis method was proposed which consisted of 6 main steps: collection of input data, data pre-processing, running model, model matching, selection of model, and sensitivity analysis. Another workflow using production data analysis was also proposed in this research to estimate the skin factor as well. The workflow consisted of three main steps: preparation of input data, selection of suitable flow regimes, and sensitivity analysis. The paper also pointed out the uncertainties of these two methods and how to deal with them in order to have highly reliable results. These proposed workflows for the two methods were then applied for a real case study with actual data and results were compared to analyze the feasibility of the proposed workflow. The factors affecting the accuracy of skin factor estimation were discussed also based on the obtained results. This research showed that it was possible to estimate skin factor daily based on production data because the difference between results obtained by the two methods were small and acceptable.
“Er-Riâye li-Hukûkillâh” Bağlamında Bir Mütekebbir Âlim Portresi
Authors: ULU Mahmut
Published: March 2023

Allah, ilim sahiplerini övmüş, onları kendisiyle ve meleklerle birlikte kendi ilahlığına şahitlik etmek gibi yüce bir makama koymuştur. İlim sahiplerinden bir kısmı bu büyük ikram karşısında şükür ile minnet duyarken bir kısmı kendisine ikram edilen bu lütfu nefsinden bilerek kibirlenmiştir. Böylece ilmiyle kibirlenen âlim tekebbüre kapılarak mütekebbirlerden olmuştur. Bundan kaynaklı olarak içinde bulunduğu şartlar ve imkânlar neticesinde kimi zaman perdelenmek suretiyle hikmetten nasipsiz bırakılmak, kimi zaman da nefsine uyup azgınlaşmak suretiyle hakikati görmekten mahrum kalabilmiştir. İnsanın kendisini biricik ve eşsiz görmesi kibir kavramıyla ifade edilmiş, bir kimsenin kibirlenmesine tekebbür, kibirlenen kimselere de mütekebbir denmiştir. Kibir tasavvufun en önemli konularından biri olan nefsin temel hususiyetlerinden biri sayıldığı için sûfîlerin dikkatini çekmiş, müellif sûfîlerin bir kısmı teliflerinde kibir ve türevlerini ele almıştır. Bunlardan biri Hâris el-Muhâsibî’dir. Bu çalışmada Muhâsibî’nin er-Riâye adlı eseri temel alınmak kaydıyla kısmen diğer tasavvuf teorisyenlerinin düşüncelerinden de istifade edilerek ilmiyle kibirlenen kimseyi ifade eden mütekebbir âlim prototipi üzerinde durulmuştur.
ЕТНІЧНІ УКРАЇНЦІ В ЛАВАХ ФРАНЦУЗЬКОГО ІНОЗЕМНОГО ЛЕГІОНУ В ІНДОКИТАЇ ТА ПІД ЧАС ПЕРШОЇ ІНДОКИТАЙСЬКОЇ ВІЙНИ 1946–1954 РР .
Authors: Чмихало Григорій
Published: March 2023

У статті досліджено участь етнічних українців, що служили та воювали у Французькому Індокитаї в основному в лавах французького Іноземного Легіону. З даної тематики наявні виключно загальні матеріали щодо перебування етнічних українців у Французькому Індокитаї та участі в подіях Першої Індокитайської війни. У статті на підставі мемуарів, спогадів, архівних матеріалів та некрологів зібрано данні щодо участі етнічних українців в подіях Першої Індокитайської та більш ранній період. Серед них розглянуто та проаналізовано спогади колишніх офіцерів Російської імператорської армії, таких як полковник Ф.І. Єлєсєєв він же лейтенант Іноземного Легіону Elise. Подано інформацію про легіонерів українського походження, що в різний час проходили службу та воювали у Французькому Індокитаї серед яких були Костянтин Слюсаренко, Федір Бак, Федір Безсмертний та інші.
Spirulina platensis effect on oxidative stress of rat’s offspring brain exposed to cigarette smoke during pregnancy and lactation
Authors: Abadi Kenny Cantika , Iswanti Febriana Catur , Jusman Sri Widia A , Fadilah Fadilah , Prijanti Ani Retno
Published: March 2023

Background: Maternal exposure to cigarette smoke during pregnancy and lactation might harmful for the fetus. The smoke contains many free radicals that could be eliminated by antioxidant. This study aimed to investigate the effect of Spirulina platensis ethanol extract as antioxidant against cigarette smoke exposure during pregnancy until lactation by assessing oxidative stress markers in neonatal brain tissues.

Methods: The experimental study used 26 offspring divided into four groups: (C) = offspring of maternal control group; (Cg) = offspring of maternal exposed to cigarette smoke; (CgSp) = offspring of maternal given spirulina and exposed to cigarette smoke; and (Sp) = offspring of maternal given spirulina only group, during gestation and 9 days lactation (30 days). Each group consisted of 6 offspring obtained from 2 adult females mated with male Sprague-Dawley rats. The exposure of cigarette smoke was 4 burn cigarettes/day for 30 days. The dose of extract was 200 mg/kg BW. The offspring were sacrificed, and the brain tissues were taken for MDA, MnSOD activity, as well as catalase activity, carbonyl, and GSH.

Results: There was no significant differences in MDA level between groups. The carbonyl, SOD, and catalase activity did not differ between the control and smoked group.

Conclusion: Exposure of four burned cigarettes smoke per day during pregnancy, and 9 days of lactation did not trigger oxidative stress. However, the effect of Spirulina platensis administration on rat offspring brain could not be analyzed.
ONLINE SPEAKING ASSESSMENT DURING THE COVID PANDEMIC:
Authors: Rohadi Tedi
Published: March 2023

Assessment is one of the basic elements of the teaching and learning process. With assessment, teachers can measure students' abilities. Teachers can measure the competencies that students achieve during the teaching process. In this pandemic era, the activity of the teaching process does not apply in the classroom. However, the teaching process can be applied online using technology. The objectives of this study are: (1) For the online voice assessment feature; (2) Investigate the implementation of online assessment of speaking skills in vocational schools; (3) Research the gaps and solutions to overcome the gaps in the implementation of online voice assessment in the pandemic era with 21st century skills. This study uses a qualitative model description to investigate the case design. The researcher collects data through interviews. The interview was conducted with an English teacher who teaches grade 12 of one of the SMKN in Kota Cirebon. The results of this study showed that the implementation of online speaking skills assessment is using WhatApp as a means of communication in the learning and assessment process, and speaking tasks are guided by using video dialogues and video presentations. The problems experienced by teachers in carrying out online speaking assessment are students' ability to think critically and responsibility to perform and fulfil the tasks; the limited media used in the online speaking skills assessment which is just WhatsApp, the kind of speaking task that is not compatible with 21st century skills. Then there are solutions to counter those problems are by teachers motivating students, guiding students in critical thinking and last but not least the role of government in developing and introducing how to use online platforms.
An Arduino-Based Smart Digital Flushable Toilet for Efficient Water Management And Enhanced Hygiene
Authors: Kabaso Winston , Zimba Aaron
Published: March 2023

Despite flushable toilet invention being helpful to humans, especially in towns and cities, flushing waste has become very expensive both in household and public places coupled with health risks of contracting some infectious diseases like streptococcus, diarrhea, etc, due to its use. These are primarily spread in public toilets such as hospitals, schools, bus stations, etc. Global warming and climate change have caused water management to become an issue that requires a concerted effort from all users, if not well managed at household and public levels, the monthly cost becomes high as some people tend to flush urine with the same amount of water as if it were stool by emptying the entire cistern into the bowl which is a waste of water hence pausing an economic challenge at both household and public places. Many people do not sanitize the toilet seat before use which if not well handled may harbor germs that may infect users. Therefore, the developed system ensures that there is automated flushing of waste with a distinct amount of water for urine and stool. The developed system also automatically sanitizes the toilet seat before someone sits on it hence reducing infectious diseases like covid-19. The system was developed using technologies and frameworks like Arduino Microcontroller which controls how the various toilet parts operate automatedly and C programming language was used for code.
Idiopathic Granulomatous Mastitis: A Management Dilemma
Authors: ABM Moniruddin  , Md Masudar Rahman  , Morsalin Rahaman  , Tanvirul Hasan  , Mst Nazmun Nahar  , Salma Chowdhury  , Baikaly Ferdous  , Md Rashed Khan  , MA Rouf
Published: March 2023

Idiopathic Granulomatous Mastitis (IGM), or Granulomatous Lobular Mastitis (GLM) or simply GM (Granulomatous Mastitis) is a benign chronic and sometimes recurrent inflammatory process of unknown etiology, involving one or both breasts, commonly in women of childbearing age. In has no definite diagnostic hallmark or marker. It is to be diagnosed by exclusion of all other diseases. Biopsy is mandatory. A challenge is there to differentiate IGM from other diseases including malignancy, tuberculosis and other granulomatous reactions, It has no specific curative treatment. Breastfeeding from the IGM breast is safe, if not on immunosuppressive or steroid treatment. It has long been classically treated with oral steroids with or without such other immunomodulators as methotrexate, azathioprine etc. Recently, intralesional triamcinolone injection has been shown to improve the symptoms. But local high concentration intralesional triamcinolone, systemic immunosuppressive agents are unsafe for breastfed babies. If a woman chooses systemic treatment, after Shared Decision Making (SDM), she should be cautioned about milk suppression and untoward effects both in mother and baby. Some women prefer no medication during lactation. Complicated cases or failure of conservative treatment calls for surgical treatment in the form of local wide resection or mastectomy etc. The patients may suffer physically, mentally, and economically, significantly lowering the quality of life. There is no consensus on its management strategies. Its management still remains as a challenge. We like to review, discuss, and share about its masked etiology, presentations, diagnostic aids plus the available avant-garde optimum management strategies.
KYAMC Journal Vol. 13, No. 04, January 2023: 250-256
HUBUNGAN LAYANAN PERAWAT DENGAN KEPUASAN PASIEN
Authors: ARIAWAN HIDAYAT SYAHFRIL
Published: March 2023

Abstract

 

Introduction : Patient satisfaction is one indicator of success of health services. One of the factors which influences patient satisfaction is nurse services. There are five aspects in providing nurse services, namely attention, acceptance, communication, cooperation, and responsibility.

Objective : The research objective was to determine the relation between nurse services and patient satisfaction in the Edelweiss room at the Islamic Hospital of Malang, UNISMA.

Research methods : This study used the Observational Analytic method with a cross-sectional approach to 52 respondents. Data was collected by using  purposive sampling technique from December 2022 to January 2023. The instrument used was a questionnaire sheet and the Statistical test used was Fisher.

Results : Based on the results of the study, from 52 respondents there are 47 respondents (90.4%) states that the nurse service was good and satisfied, while no respondents (0%) states that the nurse service was good, but it is not satisfied, and no respondents (0%) who states that the nurse service was not good but satisfied, while those who states that the nurse service was not good and dissatisfied were 5 respondents (9.6%). From the statistical test which was carried out according to the Fisher Exact Test analysis has obtained the value of p = 0.000 <0.05 . Thus H0  is rejected and H1 is accepted, which means there is a relation between nurse services and patient satisfaction in Edelweiss Room of the Malang Islamic Hospital, UNISMA.

Suggestion : For this reason, the results of this study should be used as a basic reference for improving the quality of service at the Malang UNISMA Hospital and as an initial lesson for further research.
PENGARUH TIME BUDGET PRESSURE, LOCUS OF CONTROL, DAN KOMITMEN PROFESIONAL TERHADAP PERILAKU DISFUNGSIONAL AUDIT
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Tejo Yessie Beatrix , Sofian Sofian ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: March 2023

Laporan keuangan menjadi salah satu elemen penting dalam perusahaan yang digunakan oleh banyak pemangku kepentingan. Auditor sebagai pihak ketiga memiliki bertanggung jawab untuk melakukan audit atas laporan keuangan perusahaan guna memberikan jaminan bahwa laporan keuangan perusahaan telah disajikan sesuai dengan PSAK dan bebas dari salah saji material. Dalam melaksanakan prosedur audit, time budget pressure, locus of control, dan komitmen profesional menjadi faktor-faktor yang dapat mendorong auditor melakukan perilaku disfungsional audit. Penelitian kuantitatif ini bertujuan untuk menguji pengaruh time budget pressure, locus of control, dan komitmen profesional terhadap perilaku disfungsional audit. Objek penelitian ini adalah auditor yang bekerja pada Kantor Akuntan Publik (KAP) di Wilayah Surabaya yang terdaftar pada Direktori Kantor Akuntan Publik tahun 2022. Data penelitian ini adalah data primer yang bersumber dari pembagian kuesioner. Teknik penyampelan dilakukan dengan convenience sampling. Sample penelitian ini terdiri dari 136 auditor dari 27 Kantor Akuntan Publik di Wilayah Surabaya. Teknik analisis data menggunakan analisis regresi linear berganda. Hasil penelitian ini menunjuukan bahwa time budget pressure berpengaruh positif terhadap perilaku disfungsional audit. Sedangkan locus of control dan komitmen profesional tidak berpengaruh terhadap perilaku disfungsional audit.
Assessing the demographic connectivity of common cockles in a shallow estuary as a basis for fisheries management and stock protection efforts
Authors: Hansen FT , Erichsen AC , Saurel C , Freitas PS
Published: March 2023

Common cockle Cerastoderma edule populations in the Danish Limfjorden constitute an important ecosystem component and a valuable resource for fishermen and industries, providing a large proportion of cockle landings in both Denmark and the European Union. However, processes driving cockle recruitment and mortality are not well understood, and prevent sustainable fisheries management and species protection efforts. We report a thorough study of processes that are the main drivers of population recruitment, namely larval dispersal and settlement. Outputs from biophysical modelling of cockle larval dispersal, connectivity analysis and derived graph theory metrics were used to analyse potential demographic connectivity or isolation between known cockle populations and other parts of Limfjorden. The results show that the most productive and commercially important cockle beds are almost exclusively dependent on larval imports from unexploited spawning biomass elsewhere rather than on self-recruitment, allowing for exploitation levels that would be unsustainable otherwise. Other parts of Limfjorden are relatively isolated, relying mostly on self-recruitment. The results also show that in some areas where predicted larval settlement potentials are highest, the absence of a cockle population indicates that other factors, likely environmental, are more important. This study provides an example of contrasting population dynamics and connectivity, suggesting that the vulnerability of cockle populations to exploitation or natural mortality may be highly variable and interlinked. Ignoring processes affecting larval dispersal may jeopardise cockle populations and fisheries in Limfjorden. This study highlights the importance of understanding processes of marine connectivity for the protection of bivalve populations and sustainable fisheries management.
Research of dynamics of monovalent ions in urine at various stages of urolithiasis development in in vivo experiment
Authors: Verlov N. A. , Gulina L. S. , Burdakov V. S. , Kulakov I. S. , Landa S. B. , Bogdanov A. A. , Yakovleva A. V. , Emanuel V. L.
Published: March 2023

Introduction. Experimental model of intraperitoneal injection of sodium oxalate is one of the most promising and practical models of oxalate urolithiasis in rodents.

Purpose of the study. To describe the urolithiasis progression in experimental animals with regard to the changes in the ion balance at various stages of pathology formation.

Materials and methods. We treated male ICR (CD‑1) outbred laboratory mice with a single injection of sodium oxalate (NaOx) to perform nephrolithiasis modeling. The ionic composition of urine and blood serum in the control and experimental groups was examined by capillary electrophoresis. The presence of oxalate crystals in the urine sediment and histological data can assess the severity of the pathology.

Results and conclusions. Increase of the level of Na and Ca ions and decrease of the level of K, NH4, Mg ions was observed in 4 hours and 24 hours after intraperitoneal injection of sodium oxalate, that can be regarded as a depression of tubular reabsorption and secretion.
Arterial stiffness as therapeutic target for smokers with comorbidity
Authors: Gordeev A. I. , Khidirova L. D. , Kalenova S. A. , Osmieva Z. M. , Vasilenko A. A.
Published: March 2023

Cigarette smoking has long been considered a risk factor for cardiovascular disease and a major preventable cause of death and disability in developed and developing countries. It is known that smoking can cause endothelial dysfunction and hemodynamic defects such as arterial stiffness. Among various surrogate markers of cardiovascular risk, arterial stiffness plays a central role and is a strong independent predictor of cardiovascular events, in addition to classical cardiovascular risk factors. This review presents the main mechanisms that explain the development of arterial stiffness during smoking, presents various treatment options for arterial stiffness as a therapeutic target for smokers with cardiorespiratory comorbidity.
A New MCDM Approach in Evaluating Airport Service Quality: MEREC-Based MARCOS and CoCoSo Methods
Authors: SUMERLİ SARIGÜL Sevgi , ÜNLÜ Merve , YAŞAR Esra
Published: March 2023

Service quality is seen as an important corporate strategy to ensure competitive advantage. With the increase in demand for air transport, airports have become an important venue, which has brought the issue of airport service quality to the forefront. In airports, which are described as the doors of cities opening to the world, the quality of service is determined if the service provided to passengers coincides with the level of meeting the expectations of the passenger. In this context, within the scope of the study, it is aimed to measure the quality of service by evaluating 17 airports that are evaluated as five-star airports by Skytrax in 2021 based on 11 criteria. While the importance of the criteria was determined with MEREC from the MCDM methods, the ranking of 17 airports according to the quality of service was obtained with MARCOS and CoCoSo methods. Criteria used to assess the quality of service of airports; transportation services, security screenings, immigration services, signs, arrival services, departure services, transfer passenger services, terminal comfort level, terminal facilities, shopping facilities and food/beverage services. As a result of the analysis made by the MEREC method, it was determined that the most important criterion affecting the quality of service at airports was the immigration services criterion. According to the joint results of both MARCOS and CoCoSo methods, it was determined that Chubu Centrair Airport was the airport that offered the best service quality to passengers, and Tokyo Haneda Airport was the last airport in terms of service quality.
Equivalence of the Four Fundamental Forces via Singularity Cancellation in Complex Function Theory
Authors: CHEN WEN-XIANG
Published: March 2023

This paper proposes a novel mathematical framework based on complex function theory to investigate the equivalence of the four fundamental forces: gravitational, electromagnetic, strong nuclear, and weak nuclear. By employing the properties of singularities in complex functions, we demonstrate that the equivalence can be achieved by cancelling out singularities in a specific way. Our approach not only expands the understanding of the interrelation between these forces but also provides new insights for potential unified theories.
O portato na execução pianí­stica
Authors: Richerme Cláudio
Published: March 2023

Devido a imprecisões teóricas e à pouca informação que se tem a respeito, aexecução de passagens em portato, ao piano, continua sendo objeto de dúvidas oumesmo descaso de muitos pianistas. Uma análise acústica do portato, bem como deseu contexto em alguns diferentes estilos musicais, pode trazer conclusões maisefetivas para a sua execução.Palavras"chave: portato, piano, técnica, interpretação, pedal
Traços de Max Beckmann e Naum Gabo na abertura da arte
Authors: Barroso Ana Beatriz
Published: March 2023

Interpretamos textos do artista germânico Max Beckmann (1884"1950) e dorusso Naum Gabo (1890"1977) com o intuito de estudar os possí­veis desdobramentosde uma cultura que se consolida nas vanguardas modernistas e se fortalece até opresente: a dos escritos de artistas. Sublinhamos, nesse sentido, a valorização dosenso de liberdade pessoal e de integração social apontada em obras e discursos.Enfocamos, enfim, o lento processo de abertura do sistema tradicionalmente fechadoda arte, em andamento na atualidade.Palavras"chaves: comunicação, artes, escrita, abertura.
Arte como convenção institucional
Authors: Anjos Marlon José Alves dos
Published: March 2023

O presente trabalho, através da teoria Instituição Arte avançada pelo filosofo George Dickie 1926, aborda um tema que constitui uma lacuna, ou se preferir, parte faltante na discussão sobre obras de arte ao longo da sua história: a questão da falsificação e o mundo da arte. Os sistemas de eleição dos artefatos artí­sticos, revisitando paradigmas artí­sticos, trazendo à luz a validação enquanto obra de arte em si mesma, o valor ou o menor valor do objeto e todo o longo discurso reflexivo que se forma sobre esse assunto são imprescindí­veis a um mundo em transformação.
REABILITAÇÃO COGNITIVA E MUSICOTERAPIA
Authors: Rosário Verônica Magalhães , Loureiro Cybelle Maria Veiga
Published: March 2023

As técnicas modernas de neuroimagem permitiram a documentação de alterações funcionais, estruturais e de padrões de conectividade no cérebro relacionadas com o fazer musical. Evidências cientí­ficas demonstram que a neuroplasticidade cerebral estimulada pelo treinamento musical pode produzir modificações em habilidades cognitivas. Estudos recentes nas neurociências, neuromusicologia e cognição musical tem dado destaque ao papel da música na reabilitação cognitiva. Os resultados oferecem um importante suporte para as pesquisas clí­nicas realizadas na área da musicoterapia. A principal abordagem que desenvolveu técnicas em que a música é utilizada como elemento mediador de respostas funcionais reorganizadas através de intervenções terapêuticas sistemáticas é a Musicoterapia Neurológica. O presente artigo busca apresentar alguns conceitos fundamentais resultantes de pesquisas que descrevem a utilização da música no treinamento e reabilitação de funções cognitivas como atenção, memória e funções executivas. A utilização da música na reabilitação cognitiva parece ser uma área promissora para a pesquisa em musicoterapia, principalmente valendo-se dos embasamentos teóricos nas áreas afins e das práticas resultantes dessa multidisciplinaridade.
O rap e o funk em atendimentos musicoterapêuticos em uma unidade socioeducativa
Authors: Santos Hermes Soares
Published: March 2023

O presente artigo é apresentar como estilos como o rap e o funk, cujo os conteúdos contém problemáticas sociais diversas podem ser utilizados em atendimentos musicoterapêuticos em uma unidade socioeducativa. Será apresentada uma composição de funk e os elementos de ressocialização em seu conteúdo. Serão utilizados conceitos de Identidade Sonoro Musical (ISo), um conceito da área musicoterapêutica (BARCELLOS, 2003) e conceitos da Psicologia Sóciohistórica (FURTADO, 2002) para a análise da composição.
ORQUESTANDO SONORIDADES EN VINCULARIDAD: Dispositivo ICMus para adultos en Rehabilitación Psiquiátrica
Authors: Barbaresco Maria Fernanda , Galli Giovanni , Castagnero Giovanna , Saviotti Francesco Maria
Published: March 2023

El artí­culo recorta una experiencia de investigación mixta perteneciente a un programa breve de Musicoterapia, desarrollado mediante Talleres Grupales semanales durante 5 meses del año 2016. Los participantes fueron adultos con diagnóstico psiquiátrico en rehabilitación del Departamento de Salud Mental de una institución pública italiana. El proyecto tuvo como finalidad valorar la praxis musicoterapéutica basada en la evidencia tomando como referencia principal los conceptos publicados por el Equipo ICMus (Investigación, Clí­nica y Comunidad Musicoterapéutica) [1], y se caracterizó por tener una doble meta asistencial e investigativa: Sensibilización de las debilidades y fortalezas con empoderamiento de las capacidades intra e interpersonales para un mayor despliegue de la expresión y creatividad potencial en el afrontamiento de la vida cotidiana. Descripción y análisis de los campos sonoro-notables individuales y su relación con una selección de variables psicológicas, y de las estéticas psicosonoras grupales que constituyeron la base del proceso de subjetivación y salud. La metodologí­a utilizada consistió en entrevistas individuales preliminares y sesiones musicoterapéuticas grupales, orientadas por la escucha de la singularidad y los emergentes relacionales colectivos. El registro y procesamiento de los datos fue efectuado a través de autoevaluaciones completadas por los propios usuarios como mediante matrices y protocolos con contrastación de profesionales en 3 paí­ses. La resultante tuvo la marca que señala el tí­tulo del estudio: un dispositivo musicoterapéutico, una indagación empí­rica y un tiempo acotado que supo integrar sonoridades al servicio de la vincularidad grupal.
ARTE & ADVERSIDADE: UMA ESPERANÇA EQUILIBRISTA PARA O ENSINO MÉDIO EM TEMPOS SOMBRIOS
Authors: Combinato Denise Stefanoni , Endrizzi Ana Dair Moraes Ortiz , Lima Dayse Rodrigues de , Bahiense Deborah Caroline Ramos , Reis Gislaine Aparecida dos , Camargo Karina Aparecida de
Published: March 2023

Considerando a possibilidade de a arte promover reflexão e alento em momentosde adversidade, o objetivo geral deste trabalho foi ampliar a experiência de estudantesdo Ensino Médio articulando arte e pandemia, tendo em vista o fortalecimento para oenfrentamento das adversidades ocasionadas pela pandemia da COVID-19, incluindoaspectos subjetivos, sociais e de ensino-aprendizagem. A partir da canção "O Bêbado e aEquilibrista" , composta por Aldir Blanc e João Bosco, buscamos discutir, refletir e criar comalunos de uma escola estadual de ensino integral através da participação em uma disciplinaeletiva com ensino remoto. Adotamos uma abordagem qualitativa pautada na pesquisaaçãoe fundamentada na Pedagogia histórico-crí­tica e Psicologia histórico-cultural. Após aapresentação e discussão da música – significados e contexto da composição, propomosa criação de paródias a fim de incentivar os alunos a expressarem seus sentimentos emforma de arte. Como resultado, identificou-se nos relatos e nas composições dos alunosexpressões de solidão, isolamento, perdas, medo, saudade e, ao mesmo tempo, esperançaem relação ao futuro. Destaca-se que, antes da atividade proposta, os sentimentos dosalunos eram predominantemente negativos e, após a expressão artí­stica, os sentimentosse transformaram e foram identificados a, por exemplo, feliz, calmo, tranquilo, entre outros.
Sintesis de las Artes: Una Utopia de la Modernidad y el Escultor Jorge Oteiza
Authors: Arnaiz Ana Maria , Elorriaga Jabier , Laka Xabier
Published: March 2023

Entender la modernidad artí­stica de las primeras vanguardias pasa por situarse frente a uno de sus mayores legados que artí­stica y vitalmente nos ha determinado: la voluntad de una "sí­ntesis de las artes" , uno de los ejes constituyentes de la modernidad y punto de inflexión de todo el devenir de la práctica artí­stica desde principios del siglo XX hasta los nuevos ámbitos de operatividad e integración de arte-arquitectura-ciudad-comunidad en la actualidad.Este empeño de colaboración entre las artes hizo posible un proceso moderno irreversible que llevaba implí­cita la búsqueda de una nueva noción de monumentalidad: la creencia común del espí­ritu moderno para recuperar unarelación con lo público que trabajase sobre las nuevas bases del sentimiento de lo colectivo, una vida comunitaria activa, mediante la creación de un ámbito común interdisciplinar. Una "nueva monumentalidad" donde la ciudad, como verdadero y complejo fenómeno cultural de la modernidad, estaba vinculada a ella y la sí­ntesis serí­a el vehí­culo para su transformación en obra de arte total: "la ciudad como obra de arte" .Toda ello supuso el establecimiento de una nueva era para la arquitectura y el arte, una nueva y estrecha relación entre ambas, desde el extremo de lo programático y universal de los primeros planteamientos utópicos de las primeras vanguardias, hasta los enfoques sociales y vitalistas de la "crisis" tardomoderna del modelo en la década de los 50. La aspiración de la modernidad, de crear un nuevo espacio por la obra de arte integrada, quedaba ya inoculado en la esencia y en el devenir del arte y sus disciplinas.Será en el escultor vasco Jorge Oteiza y en su praxis de integración "conclusiva" de escultura, arquitectura, ciudad y comunidad en una unidad indivisible, donde encontraremos un entendimiento pleno de esa utopí­a moderna de la "sí­ntesis de las artes" .
Por um Olhar Contemporâneo
Authors: De Almeida Bruno Gomes
Published: March 2023

O presente texto reflete sobre o que consideramos como sendo as principais caracterí­sticas de um suposto "olhar contemporâneo". A arte contemporânea, além de ter dado vazão a uma vastidão de repertórios dos mais variados meios e feituras, foi capaz de consolidar um processo instaurado por uma prática que busca cada vez mais a ampliação de seu próprio território de ação, assegurando muito mais do que um procedimento, uma postura diferente diante do mundo. Dessa forma, relevando os trabalhos de importantes precursores desta tendência, busca-se uma reflexão que considere os aspectos essenciais dessa postura que caracteriza o "contemporâneo" na arte. Entendendo o termo menos sob o ponto de vista da categoria ou gênero artí­stico, e mais pela nova condição que ele inaugura, algo que transpassa os processos de criação e produção artí­sticos, adentrando a esfera da existência. Dessa maneira, o "contemporâneo" promove um outro "olhar", outras formas de perceber a realidade, como se o status quo do artista se liberasse do aprisionamento do "ato criador" e sugerisse a sua condição a qualquer um que queira experimentar o "lugar do artista", ampliando sua existência para a atuação de um verdadeiro "agenciador de sentidos".
Coleção como arquivos de memória: processo, poética e conservação
Authors: Penna Tatiana Duarte , Froner Yacy-Ara
Published: March 2023

Trata-se do estudo do acervo do artista plástico Pedro Moraleida Moraleida falecido em 1999, no que diz respeito a sua poética , processo e conservação. Relatos e testemunhos, publicações e exposições e de seus próprios escritos guardados em espaços reais e imaginários possibilitaram uma nova narrativa através de um novo corpus e um novo significado.
Application of different watershed units to debris flow susceptibility mapping: A case study of Northeast China
Authors: Lv Jiangfeng , Qin Shengwu , Chen Junjun , Qiao Shuangshuang , Yao Jingyu , Zhao Xiaolan , Cao Rongguo , Yin Jinhang
Published: March 2023

The main purpose of this study was to compare two types of watershed units divided by the hydrological analysis method (HWUs) and mean curvature method (CWUs) for debris flow susceptibility mapping (DFSM) in Northeast China. Firstly, a debris flow inventory map consisting of 129 debris flows and 129 non-debris flows was randomly divided into a ratio of 70% and 30% for training and testing. Secondly, 13 influencing factors were selected and the correlations between these factors and the debris flows were determined by frequency ration analysis. Then, two types of watershed units (HWUs and CWUs) were divided and logistic regression (LR), multilayer perceptron (MLP), classification and regression tree (CART) and Bayesian network (BN) were selected as the evaluation models. Finally, the predictive capabilities of the models were verified using the predictive accuracy (ACC), the Kappa coefficient and the area under the receiver operating characteristic curve (AUC). The mean AUC, ACC and Kappa of four models (LR, MLP, CART and BN) in the training stage were 0.977, 0.931, and 0.861, respectively, for the HWUs, while 0.961, 0.905, and 0.810, respectively, for the CWUs; in the testing stage, were 0.904, 0.818, and 0.635, respectively, for the HWUs, while 0.883, 0.800, and 0.601, respectively, for the CWUs, which showed that HWU model has a higher debris flow prediction performance compared with the CWU model. The CWU-based model can reflect the spatial distribution probability of debris flows in the study area overall and can be used as an alternative model.
Uncovering the significance of expanded CD8+ large granular lymphocytes in inclusion body myositis: Insights into T cell phenotype and functional alterations, and disease severity
Authors: McLeish Emily , Sooda Anuradha , Slater Nataliya , Kachigunda Barbara , Beer Kelly , Paramalingam Shereen , Lamont Phillipa J. , Chopra Abha , Mastaglia Frank Louis , Needham Merrilee , Coudert Jerome David
Published: March 2023

Introduction

Inclusion body myositis (IBM) is a progressive inflammatory myopathy characterised by skeletal muscle infiltration and myofibre invasion by CD8+ T lymphocytes. In some cases, IBM has been reported to be associated with a systemic lymphoproliferative disorder of CD8+ T cells exhibiting a highly differentiated effector phenotype known as T cell Large Granular Lymphocytic Leukemia (T-LGLL).

Methods

We investigated the incidence of a CD8+ T-LGL lymphoproliferative disorder in 85 IBM patients and an aged-matched group of 56 Healthy Controls (HC). Further, we analysed the phenotypical characteristics of the expanded T-LGLs and investigated whether their occurrence was associated with any particular HLA alleles or clinical characteristics.

Results

Blood cell analysis by flow cytometry revealed expansion of T-LGLs in 34 of the 85 (40%) IBM patients. The T cell immunophenotype of T-LGLHIGH patients was characterised by increased expression of surface molecules including CD57 and KLRG1, and to a lesser extent of CD94 and CD56 predominantly in CD8+ T cells, although we also observed modest changes in CD4+ T cells and γδ T cells. Analysis of Ki67 in CD57+ KLRG1+ T cells revealed that only a small proportion of these cells was proliferating. Comparative analysis of CD8+ and CD4+ T cells isolated from matched blood and muscle samples donated by three patients indicated a consistent pattern of more pronounced alterations in muscles, although not significant due to small sample size. In the T-LGLHIGH patient group, we found increased frequencies of perforin-producing CD8+ and CD4+ T cells that were moderately correlated to combined CD57 and KLRG1 expression. Investigation of the HLA haplotypes of 75 IBM patients identified that carriage of the HLA-C*14:02:01 allele was significantly higher in T-LGLHIGH compared to T-LGLLOW individuals. Expansion of T-LGL was not significantly associated with seropositivity patient status for anti-cytosolic 5'-nucleotidase 1A autoantibodies. Clinically, the age at disease onset and disease duration were similar in the T-LGLHIGH and T-LGLLOW patient groups. However, metadata analysis of functional alterations indicated that patients with expanded T-LGL more frequently relied on mobility aids than T-LGLLOW patients indicating greater disease severity.

Conclusion

Altogether, these results suggest that T-LGL expansion occurring in IBM patients is correlated with exacerbated immune dysregulation and increased disease burden.
Effect of inlet pipe design on self-cleaning ability of a circular tank in RAS
Authors: Zhang Yuji , Yang Xu , Hu Jiajun , Qu Xiaoyu , Feng Dejun , Gui Fukun , Zhu Fang
Published: March 2023

To improve the water reuse efficiency of circular recirculating aquaculture tanks in Recirculating Aquaculture Systems (RAS) this research investigated the effect of inlet pipe deployment distance d (the distance between the stream tube hole and the tank wall) and the inlet pipe deployment angle α (the acute angle between the inlet pipe jetting direction and the nearest tank wall) on the self-cleaning ability of the circular aquaculture tank under dual and single inlet pipe designs. First, waste collection experiments were conducted to figure out the preferable inlet pipe design based on the efficiency of waste collection. Then, flow field measurement experiments were carried out employing the Particle Image Velocimetry (PIV) technique to measure the flow field in the near bottom layer of the tank, and the essential mechanism of the inlet pipe deployment on the waste collection was explored by analyzing the flow field and the corresponding hydrodynamic characteristic indicators, such as the average flow velocity (vavg), the uniformity coefficient of water flow (DU50), and the water resistance coefficient (Ct). The results indicate that the variations of waste movement, flow filed and hydrodynamic indicators are consistent in both designs of dual inlet and single inlet, and merely differ in the absolute value. Based on the comprehensive analysis, the optimal performance of self-cleaning can be obtained at α=0°~10°, 20°~30°, 40°~50° for d=1/2 r, 1/4 r, and 1/50 r, respectively. At the same flow rate condition, the jetting velocity of the inlet pipe in the single inlet pipe design is significantly greater than that in the dual inlet pipe design, and the hydrodynamic characteristics of the waste collection are better. Therefore, in circulating water aquaculture production, it is recommended to design the inlet pipe in a similar aquaculture tank to the single inlet pipe with d=1/4 r, α=20°~30°, thus improving the self-cleaning ability of the aquaculture tank. The study results also provide a reference for adjusting the inlet pipe in circular recirculating aquaculture tank.
Transcriptome profile of halofuginone resistant and sensitive strains of Eimeria tenella
Authors: Sun Pei , Wang Chaoyue , Zhang Yuanyuan , Tang Xinming , Hu Dandan , Xie Fujie , Hao Zhenkai , Suo Jingxia , Yu Yonglan , Suo Xun , Liu Xianyong
Published: March 2023

The antiparasitic drug halofuginone is important for controlling apicomplexan parasites. However, the occurrence of halofuginone resistance is a major obstacle for it to the treatment of apicomplexan parasites. Current studies have identified the molecular marker and drug resistance mechanisms of halofuginone in Plasmodium falciparum. In this study, we tried to use transcriptomic data to explore resistance mechanisms of halofuginone in apicomplexan parasites of the genus Eimeria (Apicomplexa: Eimeriidae). After halofuginone treatment of E. tenella parasites, transcriptome analysis was performed using samples derived from both resistant and sensitive strains. In the sensitive group, DEGs associated with enzymes were significantly downregulated, whereas the DNA damaging process was upregulated after halofuginone treatment, revealing the mechanism of halofuginone-induced parasite death. In addition, 1,325 differentially expressed genes (DEGs) were detected between halofuginone resistant and sensitive strains, and the DEGs related to translation were significantly downregulated after halofuginone induction. Overall, our results provide a gene expression profile for further studies on the mechanism of halofuginone resistance in E. tenella.
An open-label observational study and meta-analysis of non-invasive vagus nerve stimulation in medically refractory chronic cluster headache
Authors: Simmonds Lucy , Lagrata Susie , Stubberud Anker , Cheema Sanjay , Tronvik Erling , Matharu Manjit , Kamourieh Salwa
Published: March 2023

Background

Many patients with cluster headache (CH) are inadequately controlled by current treatment options. Non-invasive vagus nerve stimulation (nVNS) is reported to be effective in the management of CH though some studies suggest that it is ineffective.

Objective

To assess the safety and efficacy of nVNS in chronic cluster headache (CCH) patients.

Method

We prospectively analysed data from 40 patients with refractory CCH in this open-label, observational study. Patients were seen in tertiary headache clinics at the National Hospital for Neurology and Neurosurgery and trained to use nVNS as preventative therapy. Patients were reivewed at one month and then three-monthly from onset. The primary endpoint was number of patients achieving ≥50% reduction in attack frequency at 3  months. A meta-analysis of all published studies evaluating the efficacy of nVNS in CCH was also conducted. We searched MEDLINE and EMBASE for all studies investigating the use of nVNS as a preventive or adjunctive treatment for CCH with five or more participants. Combined mean difference and responder proportions with 95% confidence intervals (CI) were calculated from the included studies.

Results

17/40 patients (43%) achieved ≥50% reduction in attack frequency at 3  months. There was a significant reduction in monthly attack frequency from a baseline of 124 (±67) attacks to 79 (±63) attacks in month 3 (mean difference 44.7; 95% CI 25.1 to 64.3; p < 0.001). In month 3, there was also a 1.2-point reduction in average severity from a baseline Verbal Rating Scale of 8/10 (95% CI 0.5 to 1.9; p = 0.001). Four studies, along with the present study, were deemed eligible for meta-analysis, which showed a responder proportion of 0.35 (95% CI 0.07 to 0.69, n = 137) and a mean reduction in headache frequency of 35.3 attacks per month (95% CI 11.0 to 59.6, n = 108), from a baseline of 105 (±22.7) attacks per month.

Conclusion

This study highlights the potential benefit of nVNS in CCH, with significant reductions in headache frequency and severity. To better characterise the effect, randomised sham-controlled trials are needed to confirm the beneficial response of VNS reported in some, but not all, open-label studies.
Life changing response to successive surgical interventions on cranial venous outflow: A case report on chronic fatigue syndrome
Authors: Higgins J. Nicholas P. , Axon Patrick R. , Lever Andrew M. L.
Published: March 2023

Recognition of similarities between chronic fatigue syndrome and idiopathic intracranial hypertension (IIH) has raised suggestions that they might be connected, with chronic fatigue syndrome representing a mild version of IIH, sharing many of its symptoms, but without the signature features of elevated intracranial pressure that characterize the complete syndrome. A further development of this idea factors in the effects of a cerebrospinal fluid leak, a known complication of IIH, to explain cases where symptoms seem out of proportion to the apparent physiological disturbance. Cranial venous outflow obstruction has been proposed as the pathological substrate. We describe a patient with multiple symptoms, including headache and disabling fatigue, in which this model guided investigation and treatment. Specifically, CT and catheter venography identified focal narrowings of both jugular and the left brachiocephalic veins. Treatment of brachiocephalic obstruction was not feasible. However, in separate surgical procedures, relief of jugular venous obstruction produced incremental and significant clinical improvements which have proven durable over the length of follow-up. We suggest that investigating chronic fatigue syndrome under this model might not only bring benefit to individual patients but also will provide new insights into IIH and its relationship with spontaneous intracranial hypotension.