bluuebunny/crossref_metadata_2025 huggingface dataset:
Loss of interleukin-10 activates innate immunity to eradicate adult T-cell leukemia-initiating cells
Authors: El Hajj Hiba , Hleihel Rita , El Sabban Marwan , Bruneau Julie , Zaatari Ghazi , Cheminant Morgane , Marçais Ambroise , Akkouche Abdou , Hasegawa Hideki , Hall William , De Thé Hugues , Hermine Olivier , Bazarbachi Ali
Published: February 2021

Adult T cell leukemia/lymphoma (ATL) is associated to chronic human T cell leukemia virus type 1 (HTLV-1) infection and carries a poor prognosis. Arsenic trioxide (AS) and interferon-alpha (IFNα) together selectively trigger Tax viral oncoprotein degradation and cure Tax-driven murine ATL. AS/IFNα/zidovudine treatment achieves a high response rate in patients with chronic ATL. Interleukin 10 (IL-10) is an immuno-suppressive cytokine whose expression is activated by Tax. Here we show that, in ATL, AS/IFNα-induced abrogation of leukemia initiating cell activity requires IL-10 expression shutoff. Loss of IL-10 secretion drives production of inflammatory cytokines by the microenvironment, followed by innate immunity-mediated clearance of Taxdriven leukemic cells. Accordingly, anti-IL-10 monoclonal antibodies significantly increased the efficiency of AS/IFNα therapy. These results emphasize the sequential targeting of malignant ATL cells and their immune microenvironment in leukemia initiating cell (LIC) eradication and provide a strong rational to test AS/IFNα/anti-IL10 combination in ATL.
Risk Management Mitigation in the New Normal Era
Authors: Wijaya Oscarius Yudhi Ari
Published: February 2021

The mitigation of business risk management in the Covid 19 pandemic is a powerful means of controlling the transmission and easing of socio-economic interactions. To avoid Covid 19 transmission, business organizations should adopt new cultural behaviors that align with proper health protocols to avoid Covid 19 transmission. This is because there are differences in the behaviors of business organizations. This research uses a qualitative approach with a literature study. It focuses on business and management mitigation risk factors in Covid 19 pandemic, as well as their impact on its transmission. The results show that the Covid 19 pandemic risk impacts private businesses as well as the state as a public organization entity equally responsible for solving the problem. Furthermore, no business is ready with adequate risk management planning for Covid 19 transmission. This has an impact on the risk of uncertainty for business sustainability. Moreover, there needs to be a proper theoretical, conceptual, and empirical risk management mitigation of Covid 19 transmission. Consequently, this enhances the control of transmission in office and business place clusters.
Estimación de Parámetros para un Modelo del SARS-CoV-2 en Ecuador en Presencia de Incertidumbre
Authors: Castro Paula , De los Reyes Juan Carlos , González-Andrade Sergio , Merino Pedro
Published: February 2021

En este artículo presentamos el modelo matemático de tipo compartimental con individuos asintomáticos utilizado por el Centro de Modelización Matemática (MODEMAT) para estudiar la propagación del SARS-CoV-2 en Ecuador, así como el esquema variacional de tipo bayesiano desarrollado para estimar los diferentes parámetros del modelo, en presencia de incertidumbre de los datos observados. Esta estimación permite realizar actualizaciones periódicas del número efectivo de reproducción, así como proyecciones a corto plazo, mediante métodos de ensamble de la incidencia de la epidemia.
Diseño de un Controlador Predictivo Aplicado a un Convertidor Reductor de Corriente Continua
Authors: Medina Sánchez Martín , Naranjo Cevallos Marjorie
Published: February 2021

En el presente artículo, se presenta el diseño de un controlador predictivo (MPC) aplicado a un convertidor reductor de corriente continua. En un principio se muestra el análisis matemático del convertidor reductor y se obtiene su modelo matemático lineal y no lineal, considerando los modos de conducción continua y discontinua del convertidor. Se presenta la metodología para diseñar el controlador predictivo basado en el método de matriz dinámica de control, y para disminuir la carga computacional, se optimiza analíticamente la función de costo del controlador predictivo. Para contrastar los beneficios del control MPC, se propone el diseño de un controlador convencional proporcional, integral y derivativo (PID). Mediante simulación, se evalúa la respuesta transitoria temporal del sistema no lineal de la planta bajo los controladores MPC y PID. Se concluye que la respuesta de la planta con el controlador MPC presenta una respuesta transitoria aceptable y sin error en estado estacionario. Finalmente, se comparan las bondades de cada uno de los dos controladores diseñados.
The Relationship Between Caregiver Workload and Stress Levels with Clinical Symptom Severity in Cerebral Palsy
Authors: Özden Fatih , Arık Ahmet , Özkeskin Mehmet , Bakırhan Serkan
Published: February 2021

The aim of this study is to compare the functional status, spasticity, motor function status of children with cerebral palsy and their caregivers' workload and stress levels. A single-center prospective cross-sectional study was carried out with 30 children with Cerebral Palsy (CP) and their 30 caregivers. The clinical status of the children was assessed with the Modified Ashworth Scale (MAS), Gross Motor Function Classification System (GMFCS), The Functional Independence Measure for Children (WeeFIM). The caregivers' workload and stress levels were evaluated with Bakas Caregiving Outcomes Scale (BCOS) and Perceived Stress Scale (PSS), respectively. The mean age of the children was 11.46±7.45 years. In correlation analysis, the caregivers' BCOS score was related to the children's MAS score (p<0.05). On the other hand, there was a significant relationship between BCOS and PSS scores of the caregivers (p<0.05). Greater levels of spasticity in the children were associated with greater levels of workload. Stress level is higher in caregivers with a high workload.
Gravidez na adolescência: Contribuições dos profissionais de saúde frente à educação sexual e reprodutiva
Authors: Alves Rayssa Stéfani Sousa , Sousa Francisco Lucas Leandro de , Leite Airton César , Silva Mariana Pereira Barbosa , Silva João Kelson Araújo da , Silva Elielson Rodrigues da , Santos Sidney Freires dos , Rodrigues Hugo Alexandre , Maia Carlos Colares , Silvestre Filipe Eugênio Rodrigues , Almeida Luiz Fernando de , Sorio Cristiany Favalessa , Favalessa Ana Rosemere , Santos Bruna Kely Oliveira , Amando Maria Augusta Oliveira , Mendonça Leticia César Jatobá , Miranda Carolina Queiroga de , Fernandes Jéssica Moreira , Morais Lynna Stefany Furtado
Published: February 2021

Este estudo tem como objetivo compreender as contribuições dos profissionais de saúde frente a educação sexual e reprodutiva das adolescentes. Trata-se de uma revisão integrativa de literatura, com abordagem qualitativa, realizada por meio da buscativa de artigos indexados na Biblioteca Virtual em Saúde (BVS), com o auxílio das seguintes bases de dados: Scientific Electronic Library Online (SCIELO), National Center for Biotechnology Information (PUBMED), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS). Os critérios de inclusão compreendem pesquisas de revisão da literatura disponíveis nos bancos de dados descritos, compreendidos entre os anos de 2000 a 2020. Como critérios de exclusão, não foram considerados artigos mediante a recompensação monetária, incompletos e não convergentes com este estudo. Após a aplicação dos critérios de inclusão e exclusão, restaram 14 artigos cientificos. Os resultados evidenciam a informação e o conhecimento inadequado dos adolescentes em relação às questões de sexualidade e prevenção da gravidez precoce, considerando a necessidade de uma educação sexual mais ampla com espaços de diálogos e discussões de dúvidas das adolescentes, tanto na escola, como no âmbito familiar. Portanto, é de grande importância que ocorra a participação e cooperação dos profissionais de saúde no processo de educação das adolescentes, promovendo o acesso à informações referente à métodos contraceptivos, conhecimento sobre as DST e orientações quanto as consequencias de uma gravidez precoce para a sua vida familiar, na escola ou na vida profissional, repercutindo sobre os projetos pessoais.
Probióticos na prevenção e tratamento das doenças periodontais
Authors: Massambani Natan Santos , Fernandes Nicolly Cardoso , Costa Priscila Paganini , Pedriali Maria Beatriz Bergonse Pereira , Ito Fernanda Akemi Nakanishi , Maia Luciana Prado
Published: February 2021

A literatura tem demonstrado que os probióticos podem ser um possível aliado na prevenção e tratamento das doenças periodontais. O presente estudo tem como objetivo revisar a literatura quanto ao uso dos probióticos na prevenção e tratamento das doenças periodontais. Na maioria dos estudos clínicos incluídos nessa revisão de literatura, os probióticos apresentaram resultados favoráveis quando usados na prevenção e como auxiliares ao tratamento da gengivite e periodontite, trazendo melhora no índice de placa, índice gengival e redução na profundidade de sondagem, além da redução de microrganismos periodontopatogênicos e alteração da resposta imunológica. Os probióticos apresentaram resultados favoráveis na maioria dos estudos clínicos incluídos nessa revisão de literatura, quando usados na prevenção e como coadjuvante. Entretanto ainda se fazem necessários mais estudos para se estabelecer protocolos mais claros quanto às cepas mais indicadas, meios de utilização e o tempo de uso.
Avaliação da qualidade e do entendimento das Gestantes e Puérperas na Atenção Primária no Pré-natal
Authors: Silva Dayane Lima Caldeira da , Cebriano Gabriel Conde y Martin , Figueiredo Helga Rocha Pitta Portella , Passos Isabelle Cristiny Gregorio Amorim , Barbosa Karen Lorrana Reis , Andrade Paloma Pereira de , Santos Thiago Nascimento Sousa , Santiago Victória Emília Leitão
Published: February 2021

O objetivo visa apresentar a importância de um pré-natal de qualidade, de como esta gestante recebe as informações e se recebe, e sobre o impacto das informações passadas durante esse período. Trata-se de um estudo de revisão integrativa, de natureza qualitativa, que proporciona de uma forma ampla o conhecimento e a incorporação da aplicabilidade de artigos anteriores com assuntos que apresentam hipóteses idênticas ou relacionadas ao tema. Para levantamento dos dados, foram utilizadas as palavras-chave e alguns critérios de inclusão, como: ter coleta de dados que apresentem a visão da gestante durante o ciclo gravídico puerperal e estudo que tenha sido realizado em âmbito nacional. E como resultado selecionamos para o estudo 14 artigos relacionados ao tema e posteriormente classificados em duas categorias: percepção da gestante e/ou puérperas e, qualidade da assistência. Mesmo com alguns pontos positivos, concluímos que, os estudos apresentados destacam que ainda há necessidade de melhorias na estratégia, promoção e educação em saúde no atendimento básico ao pré-natal para que tenhamos efetividade e qualidade adequada em todo o Brasil. Sendo assim, é indubitável que ainda exista um déficit em relação à qualidade da assistência na Atenção Primária à Saúde (APS) à gestante e puérpera. Por esse motivo, sugerimos utilizar a tecnologia atual a nosso favor para incentivo e também, a realização de mais estudos e revisões com estes cenários.
Impact of 10-valent pneumococcal conjugate (PCV 10) vaccination on incidence and mortality rates of pneumococcal meningitis in children under 5 in Brazil
Authors: Nóbrega Mércia de França , Medeiros Larissa Mercielly Nóbrega , Sáfadi Marco Aurélio Palazzi
Published: February 2021

The objective of this study was to assess the impact of 10-valent pneumococcal conjugate (PCV10) vaccination on the incidence and mortality of pneumococcal meningitis in children under 5 in Brazil. A descriptive ecological, population-based quantitative study of secondary data from SINAN records for 2003-2009 and 2011-2017 and on vaccine coverage for 2011-2017 was conducted. The study was approved under permit CAAE 23629719.6.0000.5181. After PCV10 vaccine introduction, a substantial consistent reduction in incidence of and mortality rates of pneumococcal meningitis (70.33% Northeast, 69.49% Southeast) was observed across all regions of Brazil. Although the Human Development Index (HDI) improved during the study period, lethality rates remained high (North = 34.45% pre versus 40.08% post-vaccination), with no clear pattern of reduction associated with improved HDI in Brazil. In the final years of the study, a concerning decline in vaccination coverage rates was evident. Only the South (96.52%) and Mid-West (96.17%) regions attained the ≥ 95% vaccine coverage recommended by the Ministry of Health. This situation highlights the need for urgent measures to restore coverage rates and prevent recrudescence in cases and deaths associated with potentially preventable diseases.
Wild and farmed burbot Lota lota: differences in energy consumption and behavior during the spawning season
Authors: Slavík O , Horký P
Published: February 2021

Farmed fish released in a native environment can display different spawning behaviour compared to their wild conspecifics. In our study, farmed and wild burbot, a species recently introduced for aquacultural production, were equipped with electromyogram (EMG) radio tags. EMG biotelemetry allows a description of the spatial distribution of fish together with simultaneous measurements of individual energy consumption. Farmed burbot were released into the wild to simulate stocking or hatchery escape and were observed over a nocturnal phase during November to January. The observational period was assumed to cover the whole spawning season, including an expected peak of spawning activity determined according to egg production by naturally spawning burbot in an experimental seminatural river channel. We detected increased energy consumption and lower movement activity at the time of expected peak spawning for wild burbot only. Across the whole spawning season, farmed females showed lower movement activity and energy consumption than wild females, whereas the opposite results were found for farmed males. Farmed and wild fish kept larger distances between each other than the individuals within a group (farmed and wild) across the whole spawning season. The closest positions occurred between males and females in the wild group, while for farmed fish, the closest position was found within the same sex. Sexually conditioned energy consumption and spatial distribution differed between wild and farmed fish.
New clearance evaluation method for hepatological diagnostics
Authors: Tichý JA , Loučka M , Trefný ZM , Hojerová M , Svačinka J , Müller J , Friedrichová M
Published: February 2021

Pulse dye densitometry (PDD) enables the evaluation of
hemodynamic state as well as liver function. A repeated
examination, even after a short pause (or under stress
condition), enables to follow safely the dynamics of liver
pathology. From presented parameters we have evaluated as
reliable the C5-clearance, an expression of equilibrium state in
the two compartment liver system. Furthermore, T-index
expresses ratio of C5 value to cardiac output, it is a sensitive
indicator of the blood pole, i.e. sinusoidal uptake, which is in very
good correlation with staging of hepatopathies. The isolated h
constant in correlation to T-index is valuable For functional
grading. The Japanese automatic analyzer of indocyanine green
(ICG) dilution and elimination curves, after incorporation of a two
compartment mathematical model, becomes more useful for
complex hepatological diagnostics. Non-invasive PDD is becoming
of uppermost importance to clinical interest, yielding comparable
results as other complicated and invasive examinations and may
be, therefore, repeated in short time intervals for different
indications with minimal stress of examined patient.
Fiber type composition of unoperated rat soleus and extensor digitorum longus muscles after unilateral isotransplantation of a foreign muscle in long-term experiments
Authors: Soukup T , Smerdu V , Zachařová G
Published: February 2021

We examined the effects of the unilateral heterochronous
isotransplantation on the fiber type composition and myosin
heavy chain (MyHC) isoform content of unoperated slow soleus
and fast extensor digitorum longus muscles of female inbred
Lewis strain rats. Comparison was made between “control”
unoperated muscles of experimental rats (after intramuscular
transplantation surgery) with the corresponding muscles of
completely naive (unoperated) rats of three age groups (5-, 8-
and 14-month-old). This was done in order to ascertain whether
these muscles can be used as reliable controls to the
transplanted and host muscles for our ongoing grafting
experiments. The fiber type composition was determined by
assessing the histochemical reaction for myofibrillar adenosine
triphosphatase, the MyHC isoform content was determined
immunocytochemically using monoclonal antibodies specific to
different MyHC isoforms and by sodium dodecyl sulphate
polyacrylamide gel electrophoresis. Our experiments show that
the heterochronous intramuscular isotransplantation procedure
had no significant effect on the fiber type composition and MyHC
isoform content of the “control” unoperated muscles of the
experimental rats when compared to the corresponding muscles
of the naive animals. Furthermore, the duration and type of
isotransplantation did not also lead to differences among
corresponding “control” muscles of experimental animals. We
conclude that the unoperated muscles of the experimental rats
can be used as controls in our current transplantation project
dealing with long-term grafting experiments.
Serotonin-depleted rats are capable of learning in active place avoidance, a spatial task requiring cognitive coordination
Authors: Petrásek T , Stuchlík A
Published: February 2021

Neurotransmitter substrate of spatial cognition belongs to current
topics in behavioral neuroscience. The present study examined
the effects of serotonin depletion with p-chlorophenylalanine on
learning of rats in active place avoidance, a spatial task requiring
allothetic mapping and cognitive coordination and highly
dependent upon hippocampus. Serotonin depletion transiently
increased locomotor activity in response to footshocks, but it did
not change the avoidance efficiency measured by three spatial
parameters. These results suggest that serotonin
neurotransmission is not crucial for cognitive coordination and
allothetic learning, i.e. the processes, which are crucial for active
place avoidance performance.
Análisis de funciones matemáticas usando la primera y segunda derivada en estudiantes de Matemática y Física de la UNHEVAL
Authors: Paragua-Morales Melecio , Paragua-Macuri Carlos A. , Paragua-Macuri Melissa G. , Norberto-Chávez Liz A.
Published: February 2021

La finalidad del estudio fue probar la efectividad de la aplicación de la primera y segunda derivada para analizar las funciones matemáticas en los futuros docentes de Matemática y Física de la UNHEVAL; para ello, se hizo un estudio de tipo causa-efecto y diseño cuasiexperimental, esperando optimizar el aprendizaje de funciones de manera gráfica y analítica, mediante la ubicación exacta de los puntos máximos y mínimos, de inflexión, determinación de la concavidad hacia arriba y hacia abajo, y otros; se trabajó con una muestra de 114 estudiantes, de ellos 73 unidades de análisis eran de control y 41 experimentales; los datos fueron recogidos con las pruebas evaluativas escritas, y se procesaron obteniéndose los estadígrafos descriptivos que permitió decir que el valor Z = 7,09 es mayor respecto a la z crítica = 1,96 al 95% de confiabilidad, la cual permitió rechazar la hipótesis nula y aceptar la hipótesis de investigación, porque permite mejorar la aprehensión de la teoría y práctica, con el análisis de funciones aplicando las derivadas en los futuros docentes de matemática y física de la UNHEVAL.
Influence of Environmental Pollutants at the Pollen of Poaceae
Authors: Kobzar V.
Published: February 2021

More than 12,000 species belong to the Poaceae family globally; 300 species grow in Kyrgyzstan, anemophilous and releasing a huge amount of pollen into the atmosphere. Poaceae pollen is currently considered the leading airborne biological pollutant (PM10) and the leading cause of pollen allergy worldwide. She is one of the top global aeroallergens. Poaceae pollen has common features: small size, homogeneous morphology, high pollen production and abundance of species. The aim of this work was to study the effect of environmental pollutants on the pollen of Poaceae plants, the classification of identified teratomorphoses and assessment of their specific contribution to the aerobiological situation. The study of Poaceae pollen from various observation points of Kyrgyzstan using scanning electron microscopy revealed teratomorphoses of varying degrees of complexity: 1) deformation; 2) perforation; 3) fragmentation; 4) complex changes in the sculptural elements of the exine surface; 5) combined teratomorphosis, including several types with the transformation of one modification into another. This article summarizes the results of studies reflecting the effects of environmental pollutants on Poaceae pollen, and ultimately on the severity of symptoms and the prevalence of pollinosis.
Salinity Resistant of Introduced Woody-Shrub Species in Saline Soil of Absheron Peninsula
Authors: Asadov H. , Bagirova S. , Mirjalally I. , Efendiyeva R. , Atayeva
Published: February 2021

The aim of the scientific work is to identify the degree of salt tolerance of new tree-shrub species brought from various soil and climatic regions of the world, introduced and widely used in landscape arrangements on the Absheron peninsula of Azerbaijan. In connection with the expansion and development of urban development, greening arrangements are also expanded, the appearance of large cities changed, the number of new parks, boulevards and green spaces increased, especially in the coastal zones of the Caspian Sea embankments. The structure of the soil of the Absheron Peninsula is sandy, sandy-loamy, with low water retention capacity. The Absheron peninsula of Azerbaijan is characterized by a characteristic sign of arid zones. However, the soil composition remains unchanged, which is characterized by chloride-sulfate, sulfate-chloride and chloride-carbonate salinization. In the coastal zones, chloride-carbonate salinization predominates, mainly 1500–2000 m from the sea, mainly chloride – sulfate, and sulfate – chloride in the central part of the peninsula. Due to the degree of salinity, the degree of salt tolerance is different for different species of woody-shrub plants. In the natural flora of the peninsula tree species are completely absent, the species composition of shrubs is small, mainly are found ephemeral and ephemerid species of herbaceous plants. The objects of study were Magnolia grandiflora L., Cupressus macrocarpa L., Sophora japonica L., among shrubs Nandina domestica Thunb., Ligustrum japonicum Thunb., Jasminum nudiflorum L., Lisium chinensis Mill, Euonymus japonica L., Nerium oleander, new types of cypress trees, various types of palm trees, etc. It was revealed that, in saline soil of the Absheron peninsula, the degree of influence of salinizing ions (Cl−, SO42−, and CO32−) on the accumulation of chlorophylls in the leaves of new introduced species has a direct correlative relationship. Toxic ions affect the protein-chlorophyll bond, the destruction of chloroplasts, and a decrease in photosynthesis, resulting in the formation of chlorophyllide and phytic acid, which promotes the formation of burns on a leaf blade and reduced the photosynthetic productivity.
Genetics and Epigenetics of Alzheimer’s Disease: new Cognitive Technologies and Neurocommunication
Authors: Sirotko I. , Volobuev A. , Romanchuk P.
Published: February 2021

The 21st century Homo sapiens evolves and improves using new nano, bio, information and cognitive technologies that provide and focus on cognitive and creative processes. 21st century brain H. sapiens combines internal and external layered information into a single algorithm for structuring, routing, storing, and retrieving information in the present and future time period. 4P and 5P medicine, 5G medical services, next-generation sequencing and pharmacogenetics are new modern foundations of personalized medicine. The next-generation information and communication infrastructure of 5G for clients (patients) from the medical sphere is an intelligent border-cloud platform with an integrated cloud network architecture. Next-generation mobile technologies are being introduced in a modern hospital: from higher communication speeds to smart computing and additional reality. 5G medical services are a revolution in the medical industry. Neuromarketing and neurobytes, neuroimaging of consciousness and brain-machine interfaces, biorobots and biochips interact with the “external and internal hippocampus”. The result of human activity in a market economy and a new society is intellectual property. The heterogeneous nature of dementia (Alzheimer’s disease, Peak, frontal-temporal degeneration) and the various pathophysiological features of specific dementia highlight the need to develop separate algorithms based on current biomarkers specific to these diseases. Modern prognosis of Alzheimer’s disease is achieved by structural neuroimaging, cognitive testing, and biological indicators (genotype APOE-ε4) based, both on orders, standards, and clinical recommendations, as well as on the quantitative assessment of brain structures using neurointerfaces. The functioning of integrated neural systems through integration and analysis of dynamic hybrid multimodal neural EEG and fMRI information, combined with neuropsychological testing, will enable the geriatric clinician to manage healthy aging of H. sapiens.
Psychosomatic Behavior Styles of Patients With Disorders with Schizophrenic Specter
Authors: Bolotina N. , Ku Bok Sun
Published: February 2021

The article is devoted to the study of psychosomatic behavior styles in patients with schizophrenic spectrum disorders. Empirically revealed the relationship between the psychosomatic behavior styles and individual typological characteristics The results of the study showed that people with schizophrenic spectrum disorders have two styles of psychosomatic behavior: cognitive and socio-cultural. It was found that this sample is characterized by such personal characteristics as anxiety, introversion, lability and sensitivity.
Укладання угод про визнання винуватості у вчиненні економічних правопорушень: вітчизняний та американський підходи
Authors: Каменський Д.В.
Published: February 2021

У статті в компаративістському режимі визначено юридичні підстави та охарактеризовано правозастосовні нюанси укладання угод про визнання винуватості у вчиненні економічних правопорушень. Розкрито причини усталеної, поширеної (до 95 % від загальної кількості порушених кримінальних справ) практики американського правозастосувача в частині укладання угод про визнання винуватості, показано переваги такого інституту саме в аспекті протидії держави злочинам економічного характеру. На цьому тлі вітчизняний аналог, запроваджений у правову систему відносно нещодавно, у зв’язку з ухваленням чинного КПК, наразі сприймається як нерозвинений, відносно непоширений інститут (до 15-20 % від загальної кількості порушених кримінальних справ), водночас маючи значний потенціал для подальшого вдосконалення. Обґрунтовано авторську позицію про те, що норма ст. 389-1 КК, присвячена відповідальності за умисне невиконання угоди про примирення або про визнання невинуватості, є проявом помилкової криміналізації та повинна бути виключена.
Поняття та зміст доказування прокурором при розслідуванні корупційних злочинів у сфері службової діяльності та професійної діяльності, пов’язаної з наданням публічних послуг
Authors: Сухачова І.О.
Published: February 2021

Стаття присвячена дослідженню сучасних концепцій кримінального процесуального доказування та їх впливу на реалізацію прокурором функції обвинувачення при доказуванні кримінального правопорушення на досудовому розслідуванні корупційних злочинів у сфері службової діяльності та професійної діяльності, пов’язаної з наданням публічних послуг. У статті встановлено, що на сьогодні в теорії кримінального процесу виокремлюють п’ять сучасних концепцій кримінального процесуального доказування, які можна виділити, зважаючи на його змістовно-функціональне розуміння: пізнавальна; діяльнісна; концепція судових доказів; комплексна; системна. Автором подано визначення поняття кримінального процесуального доказування прокурора на досудовому розслідуванні корупційних злочинів у сфері службової діяльності та професійної діяльності, пов’язаної з наданням публічних послуг, а також характеристика його елементів.
Thyme Oil Enhances the Inactivation of Salmonella enterica on Raw Chicken Breast Meat During Marination in Lemon Juice With Added Yucca schidigera Extract
Authors: Kiprotich Samuel , Mendonça Aubrey , Dickson James , Shaw Angela , Thomas-Popo Emalie , White Shecoya , Moutiq Rkia , Ibrahim Salam A.
Published: February 2021

Enteric pathogens such as Salmonella enterica can survive in low pH conditions and pose a food safety threat during marinating of raw poultry meat. A study was conducted to investigate the effectiveness of thyme oil for killing S. enterica on raw chicken during marination in lemon juice containing yucca extract. Samples of raw chicken breast were inoculated with a five-serovar mixture of S. enterica (~108 CFU/mL) and immersed for 2, 4, 6, and 8 h in four lemon-based marinades at 22°C: lemon juice alone (L), L with added 0.5% yucca extract (L + Y), L + Y and 0.5% thyme oil (L + Y + 0.5% TO) and L + Y + 1.0% TO. The L and L + Y served as controls. Survivors were determined by surface plating chicken homogenates on xylose-lysine tergitol-4 (XLT4) agar and XLT4 agar overlaid with non-selective agar (TAL) and counting bacterial colonies after 48 h of incubation (35°C). Marinades containing Y and TO significantly reduced initial viable populations of S. enterica compared to control (L and L + Y) solutions (P < 0.05). Based on S. enterica survivors on TAL medium, the L and L + Y reduced initial populations by 1.12 and 1.42 Log CFU/sample, respectively, after 8 h whereas, Log reductions caused by L + Y + 0.5% TO and L + Y + 1.0% TO, respectively, were 2.62 and 3.91 (P < 0.05). Numbers of survivors were higher on TAL compared to XLT4 agar (P < 0.05); however, the extent of sub-lethal injury caused by the marinades was not statistically significant (P > 0.05). The death rate of S. enterica increased significantly (P < 0.05) in the marinades containing TO (0.5 or 1.0%) compared to control (L + Y). Based on these results, thyme oil has good potential to increase the antimicrobial efficacy of lemon juice marinade against Salmonella on raw chicken breast and enhance the microbial safety of this popular poultry product.
Resilience Improves the Sleep Quality in Disabled Elders: The Role of Perceived Stress
Authors: Cai Yumei , Wang Junlei , Hou Liwen
Published: February 2021

The current research aims to prove the impact of resilience on sleep quality and to investigate the mediating function of perceived stress in the paths from resilience to sleep quality among disabled Chinese elders. The participants were 196 elders with visual and physical disability who resided in the nursing houses in Shanghai, including 102 males and 94 females whose mean age was 74.5 years old (standard deviation = 6.81). All the elders were measured with the 10-item Connor-Davidson Resilience Scale, Pittsburgh Sleep Quality Index (PSQI), and Perceived Stress Scale. The results showed that all the demographic variables were significantly related to perceived stress and PSQI scores. High levels of resilience could significantly enhance the quality of sleep in disabled Chinese elders. In addition, the two-step mediation models also confirmed the impact of resilience on sleep quality as mediated through perceived stress in this special aged population. Better knowledge on the mechanisms of sleep quality among older adults could benefit the prevention and treatment of some geriatric diseases.
RELIABILITY ASSESSMENT OF ENERGY EQUIPMENT AT EARLY STAGE OF DESIGN
Authors: GEORGIEVSKAIA E.V.
Published: February 2021

The minimization of the manufacturing and further maintenance cost of power equipment dictated by economic requirements leads to decreasing in metal consumption, growing in the stress of its assemblies, increasing in the design lifetime and overhaul periods, and decreasing in the amount of metal condition monitoring. At the same time, the design requirements for the reliability parameters are constantly advance due to the growing required level of industrial safety. The issue of ensuring the reliability parameters is acute already at the early stages of design when the final decisions about construction, material performance, operating modes, manufacturing, and repair technologies have not yet been made. The proposed calculation approach takes into account the individual characteristics of the developed power equipment and makes it possible to assess its reliability already in the early stages of design. It uses the correlation between the probability of no-failure operation and safety factors. So, it allows us to significantly reduces design time and cost.
TRANSPORTATION DEVICES FOR NON-RIGID CYLINDRICAL PRODUCTION OBJECTS WITH GAS-MAGNETIC PALLET GUIDES
Authors: PASHKOV E.V. , VOZHZHOV A.A.
Published: February 2021

The article presents typical layouts of technological equipment for processing non-rigid cylindrical parts using the levitation effect at the stage of their transportation and loading without direct mechanical contact with the mounting and guiding elements. The dependences of the carrying capacity of aerostatic supports on the size of the working gap and air pressure, varying in a wide range, are obtained experimentally. The design and principle of operation of transport devices using the effect of levitation of pallets with objects of processing are described.
ACCOUNTING THE ENVIRONMENTAL FACTOR WHEN EVALUATING THE EFFICIENCY OF THE COOLING SYSTEMS OF SHIP POWER PLANTS
Authors: FEDOROVSKAYA N.K. , FEDOROVSKIY K.Yu. , ENIVATOV V.V.
Published: February 2021

Methods for evaluating the efficiency of cooling systems for ship power plants are considering. The expediency of the integral indicator based on the reducing costs has been substantiating. A method has been developed for accounting for the ecological consequences of the operation of ships.
NEW CONSTRUCTION AND TECHNOLOGICAL SOLUTIONS FOR CREATING A TOOL FOR DISPOSAL OF COMPOSITE MATERIALS AND THE METHOD OF THEIR ULTRASTRY DIAGNOSTICS
Authors: LI X , GALINOVSKY A.L. , ABASHIN M.I. , KRAVCHENKO I.N.
Published: February 2021

The article presents the results of two interrelated studies. The first is related to assessing the possibility of using a water-polymer ultrajet as a diagnostic tool for cutting tools for the disposal of plastics. The second is related to the development of a directly new tool design. As a result of research, it was shown that both the method of water-polymer diagnostics and the proposed design of the knife have prospects for practical application. A model of a composite tool for the disposal of composites is proposed, which potentially has high operational properties. The research results are confirmed by the data of a comparative analysis of various diagnostic methods and strength calculations of the tool.
DEVELOPMENT OF THE METHOD OF DESIGN OF TECHNOLOGICAL PROCESSES OF MANUFACTURING OF FING-SHAPED PARTS BY COMPRESSION
Authors: LAVRINENKO V.Yu. , POLYAKOV A.O.
Published: February 2021

The method has been developed for designing of technological processes for manufacturing of parts of the “ring” type by compressing of the oval blanks as a result of previous experimental and theoretical studies. The use of this method provides significant metal savings and an increase in the material utilization factor. The example of developing of technological process of stamping of ring detail by compression is presented.
Developing Philology Teachers’ Inclusive Competence in Postgraduate Education
Authors: Kazachiner Olena
Published: February 2021

This research focuses on the phenomenon of philology teachers’ inclusive competence development as a part of their professional competence.The purpose of the research is to substantiate scientifically the concept of inclusive competence development, to develop and experimentally test the system of philological disciplines teachers’ inclusive competence development in the system of postgraduate education.The following methodology tools were used as analysis, classification, and pedagogical experiments.As a result of this study, the pedagogical conditions for philological disciplines teachers’ inclusive competence development were singled out and theoretically substantiated. The first, stimulation of motivation of philological disciplines teachers to professional activity in the conditions of the inclusive educational environment. The second, updating the content of educational programs of advanced training courses for teachers of philological disciplines in view of the provisions of inclusive education. The third, combination of traditional and innovative forms and methods of teaching teachers of philological disciplines in postgraduate pedagogical education institutions for the implementation of inclusive education in general secondary education institutions. The last, involvement of language and literature teachers in team interaction with specialists of different profiles for the implementation of the tasks of inclusive education through these subjects in general secondary education institutions. It was experimentally proved that the introduction of the model of developing philological disciplines teachers’ inclusive competence in postgraduate education helps to increase their motivation to teaching languages and literature in the context of inclusion, interest in teaching children with special educational needs together with peers in general secondary education, acquisition and application of inclusive knowledge, ddeveloping inclusive skills, as well as significantly affect the level of languages and literature teachers’ professional competence in general. It was concluded that the prepared scientific and methodological support positively influences the stimulation of the process of philological disciplines teachers’ inclusive competence development.
Cybersecurity: A Key Challenge to the Information Age in Sierra Leone
Authors: Sawaneh Ibrahim Abdulai , Kamara Fatmata Kanko , Kamara Albert
Published: February 2021

Humans' growing desire to continuously interact with each other through the internet has both negative and positive consequences, especially if users tend to use it maliciously. The advent of social networking sites has broken the traditional barriers to communication. It is a cost-effective way of communicating using text-messages, video-messages, and voice-notes as it happens from a source (sender) to the audience (receivers). Anyone can participate if they have a mobile phone with internet facilities, and now, everyone is an online journalist and a reporter. Unfortunately, although social media platforms have numerous merits, these platforms still face critical challenges, especially in controlling and policing content post by users. The revolution in information technology and social networking platforms have provided a NEW NORMAL for online fraudsters and criminals. Fake news, hate speech, and political propaganda/rhetoric has created a confusing world, especially during the Covid-19 pandemic situation. Therefore, our paper presented some of the challenges and solutions to cybercrime.
Evaluasi Kesesuaian Lahan Untuk Tanaman Durian Menggunakan Metode Matching
Authors: Saputra Muhammad Frido , Adyatma Sidharta , Arisanty Deasy
Published: February 2021

Land suitability evaluation is a process of assessing the potential of land for a particular use, whether in agriculture, plantation, tourism, land conservation, or other types of use. This study aims to determine the land suitability class for durian plants in Aranio District and determine the inhibiting factors on the land using the matching method. The population in this study was 12 land units and each unit was taken 2 samples. Land units are obtained from overlay maps of landforms, slope maps, geological maps, soil association maps, and land use maps. The results showed that the land in Aranio District was included in the suitability class S2 (moderately suitable) with an area of 15069.68 hectares or 33.13%, S3 (marginally suitable) with an area of 1485.78 hectares or 3.27%, and N1 (not current suitable) with an area of 3980.03 hectares or 8.75%. The limiting factor is slope, erosion hazard, pH, soil depth, surface rock, alkaline saturation, flood hazard, phosphate, K2O, and N-Total. The villages in the Aranio sub-district are used to develop durian plants because they have land suitability classes of S2 and the use of shrubs, fields, and mixed gardens are above 50%, namely Tiwingan Baru and Tiwingan Lama villages.
Koreksi Bias Statistik Pada Data Prediksi Suhu Permukaan Air Laut Di Wilayah Indian Ocean Dipole Barat Dan Timur
Authors: Najib Mohamad Khoirun , Nurdiati Sri
Published: February 2021

The IOD can be measured using the Dipole Mode Index (DMI) which is calculated based on the sea surface temperature in the Indian Ocean. Therefore, DMI can be predicted using sea surface temperature forecasting data, such as data provided by the European Center for Medium-Range Weather Forecasts (ECMWF). However, the data still has a bias as compared to the actual data, so to get a more accurate prediction, corrected data is needed. Therefore, the aim of this study is to predict DMI based on sea surface temperature forecasting data that has been corrected for bias using the quantile mapping method, a method that connects the distribution of forecasting and actual data. The results showed that the DMI prediction using corrected data was more accurate than the DMI prediction using ECMWF data. DMI predictions using corrected data have high accuracy to predict IOD events in October-April.
Estrategias para abordar la diversidad afectivo-sexual por maestras y maestros (II)
Authors: García González Alfonso Javier , Márquez Lepe Esther
Published: February 2021

Animación didáctica en la que se habla sobre el Eje transversal 3 en Educación Afectivo-Sexual, tratando de avanzar, tanto en su primera como segunda parte, en el conocimiento de la diversidad afectivo-sexual, así como en la propuesta de diferentes estrategias educativas para su abordaje dentro del ámbito escolar.
Sabemos que las personas que tienen algún tipo de diversidad afectivo sexual siguen siendo discriminadas y excluidas en muchos ámbitos de la sociedad, incluido el educativo. Para cambiar esta situación, es fundamental reflexionar desde los espacios escolares en la complejidad de esta realidad así como en sus implicaciones psicosociales.
Este eje trata de apoyar a los actores educativos (claustros, personal de gestión e inspección y AMPAS) que quieran trabajar sobre ello, proporcionando herramientas conceptuales, metodológicas y recursos educativos en el reconocimiento de manera preventiva y proactiva de la realidad LGTBI.
Confiamos en que este recurso didáctico-tecnológico responda a necesidades educativas planteadas desde el contexto social próximo como ejemplo de transferencia de la educación superior a todos los niveles educativos.
Os Direitos Sexuais da Criança e o Ambiente Familiar
Authors: Cavalcanti Mabel
Published: February 2021

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Terapia Multimodal para Disturbios de Desejo Sexual seguindo o Contexto de Terapia Comportamental
Authors: Geber Selmo
Published: February 2021

JARROUSSE, N.; POUDAT, F. X. Terapia Multimodal para Disturbios de Desejo Sexual seguindo o Contexto de Terapia Comportamental. Contracepition-Fertilité-Sexualité 17(15): 467-471, 1989.
Grupo de mulheres
Authors: Raposo Theremilza Cristina Santana
Published: February 2021

Este texto surgiu com o convite para falar, no V Congresso Brasileiro de Sexualidade sobre “Grandes Modelos em Terapia Sexual”. Com ele, a necessidade de abordar o trabalho de nosso instituição, mas sobretudo tentar lever aos profissionais que trabalham com mulheres um exemplo de como abordar a sexualidade, numa visão de gênero, e caminho de uma construção social feminino/masculino.O NuSS - Núcleo de Saúde e Sexualidade de Brasília - Cidadania e Gênero, surgiu em 1989, a partir da união de mulheres que, atuantes no movimento feminista, em suas áreas de formação, uniram-se, para resgatar uma reflexão sobre as relações de gênero, saúde e sexualidade feminina e direitos reprodutivos. Dente processo nasceu uma ONG - Organização Não Governamental - Feminista. O NuSS integra a Rede Nacional Feminista de Saúde e Direitos Reprodutivos, que congrega cerca de 80 ONG’s. Tem ação direta em práticas educativas nos temas relacionados com a saúde e sexualidade femininas, direitos reprodu- tivos, desenvolvimento de pesquisas a estudos nestes temas. Tem ainda, como objeto de ação, o trabalho junto aos Movimentos Sociais Organizados, Sindicatos, Congresso Nacional e Câmara Legislativa do Distrito Federal. Acreditando que o trabalho feito de maneira multidis- ciplinar pode gerar crescimento, dentro de uma ação de complemen- tariedade, a equipe do NuSS é formada por 1 antropóloga, 1 médica, 1 jornalista, 1 odontóloga e 2 psicólogas. Atualmente, o NuSS vem desenvolvendo, junto a grupos de mu- lheres, um trabalho de reflexão acerca da saúde sexual e reprodutiva, bem como um despertar para a cidadania.O trabalho em grupo pode ser visto como uma nova abordagem na terapia sexual, a partir do momento em que se permita a troca e a con- strução de reflexões cujas vivências individuais adquiram, coletivamente, um novo sentido.Esta perspectiva de trazer para o público o que antes parecia priva- do, não é uma abordagem recente. Ela faz parte da reflexão dos grupos de mulheres iniciada em décadas anteriores a esta em que vivemos.
Pengembangan Sistem Pelatihan Jarak Jauh Berbasis Moodle di Balai Diklat Keagamaan Bandung
Authors: Dedi Restendi  , Firman Nugraha  , Agus Trianto
Published: February 2021

[MOODLE BASED DISTANCE TRAINING SYSTEM DEVELOPMENT IN BALAI DIKLAT KEAGAMAAN BANDUNG]. Developing online training system is essential to create equalization over training opportunities, enrich learning materials, and increase trainees participation in learning. The development is also a medium to create accessible learning environment. Online training requires learning management system. One of the most widely used applications is Moodle. It has the latest version that can be used to improve online training’s quality, namely Moodle version 3.7.1. This study aims to find out Moodle-based remote training system implementation at Bandung Religious Training Center in 2020. Research and Development waterfall model is applied. Application testing is by using blackbox techniques. The analysis uses SCORM and Haughey theory. The result showed that Moodle-based remote training is considered good based on black box tests. It can be seen from several aspects of websites, such as appearance and content, implementation, institutional readiness, as well as facilities and infrastructure. Moodle 3.7.1 based remote training websites are recommended for socialization and provided remote training manual instructions