bluuebunny/crossref_metadata_2025 huggingface dataset:
Active tectonics of western Kosova: Insights from geomorphic 1 and structural analyses
Authors: GÜRBÜZ Alper , SHALA Astrit , MUSTAFA Shemsi , ERTEN Aytekin
Published: October 2022

Kosovo is located in a key position in the central-west part of the Balkans providing an opportunity to understand the far-field effects of distributed intracontinental deformation caused by the Aegean extension in the south and Adriatic compression in the west. It is also situated along the NE-SW trending Shkodër-Pejë transverse zone, where the Dinarides and Albanides-Hellenides orogenic belts are juxtaposed. While the instrumental seismicity of the country indicates the activity of this fault zone and many others, the active faults in the country were not discussed in detail in the current literature. In this study, we analysed both the geomorphic and structural features of major mountain front faults in western Kosovo (i.e., Pejë, Istog, Krojmië and Prizen faults) to reveal the relative assessment of their activities and kinematic characters. Geomorphic and morphometric analyses of all the studied four different mountain fronts indicated high activity and tectonic uplift rates of over 0.5 mm/a. On the other hand, according to the collected kinematic data from the observed fault planes, all the studied faults are of normal character representing a dominance of NW-SE-directed extension in western Kosovo, which is most probably caused by the rollback of subducting slab in the Hellenic trench.
The Creativity And Motif of Tetuko Written Batik In Nganjuk Regency
Authors: Herlina Yekti
Published: October 2022

Nganjuk regency is known for its textile craft with itscharacteristics called Nganjukbatik. Nganjuk batik has some unique motifs such as the Ajuk Ladang, Sera Rumput, Sido Mukti Tungkak, Sundut Sate, Acacia Flower Tumpal, and Rambutan Flower Tumpal.These motifs are usually worn in any formal and informal events.Tetuko written batik of Nganjuk Regency as one of the sub-sectors of the creative industry is createdbased on local wisdom or the nation's cultural heritage. The creativity inmaking and developing this batik is needed to produce competitive and high-quality products. Thus, this study aims at determining the creativity and motifs of Tetuko written batik used during the batik-making process. It was done by employing a descriptive qualitative and experiment along with observation, interview, and documentation. The targets of conducting this study are to provide a contribution, inspiration, and innovation to encourage creative and critical thinking ability related to creativity and motifs in Tetuko written batik of Nganjuk Regency. It is expected that this batik appealsto more people and becomes a high-quality product.
Theater Elements of Mandiek Anak In Salareh AIA
Authors: Erdila Risa , Sahid Nur , Sathotho Surya Farid
Published: October 2022

This study aims to analyze the theatrical elements found in mandiekanak. Mandiekanak is a ritual that is part of BaralekGadang and only found in the Salareh Aia region. This research uses Schechner's performance studies approach to analyze research subjects. According to Carlson, the concept of cultural performance is used to look deeper at the events of mandiekanak. It also uses Dramaturgy theory to see the theatrical element while qualitative research methods collect data in purposive sampling. The collected data is then analyzed descriptively using ethnographic methods. The analysis results showed that the mandiekanak has the purpose of maintaining the family of the bride's father or bako, as for the theatrical elements in the form of scripts, performers, audiences, and venues. Manuscripts are rules that ensure the survival of a mandiekanak. The player refers to all people who are involved in it. The mandiekanak audience is participatory, while the place refers to the area where the mandiekanak exists
Ergodik Edebiyat: Yeni Bir Okuma Yöntemi mi? Hâlihazırdaki Yöntemlerin Yeni Adı mı?
Authors: TOPÇU Hayrunisa
Published: October 2022

20. ve 21. yüzyıllarda yaşanan bilimsel ve teknolojik gelişmeler yaşamın her alanını etkilemiş ve “dijital çağ” adıyla nitelendirilen yeni bir dönemi başlatmıştır. Dijitalleşmenin etkisiyle değişime uğrayan alanlardan biri de edebiyattır. Bu süreç elektronik edebiyat olarak anılan yeni bir alanın doğmasına yol açar. Elektronik edebiyat eserlerinin yaygınlaşması, yeni okuma yöntemlerine ihtiyaç duyulmasına neden olur. Bu yazının konusu olan ergodik edebiyat, elektronik metinlerin artmasıyla teori hâline getirilen bir okuma yöntemidir. Kavramın çerçevesi Espen J. Aarseth’in Cybertext Perspectives on Ergodic Literature adlı çalışmasından yola çıkılarak oluşturulacak, hipermetin ve sibermetnin tanımları yapılacak, bunların ergodik edebiyat ile ilişkisi tartışılacaktır. Çalışmanın temel amacı, ergodik edebiyat kavramının teorik düzeyde Türkçe literatüre kazandırılmasıdır.
Yürek Burgusu ile Ölüler Yaşıyorlar mı? Romanlarının Fantastik Unsurlar Bakımından Karşılaştırılması
Authors: DERE Mustafa
Published: October 2022

Fantastik; alışılmadık dünyaların ve gerçeküstü/olağandışı unsurların anlatıldığı eserlerin ortak adıdır. Daha çok roman sahasında kendisini göstermiştir ve ilk defa 1970 yılında Bulgar asıllı Fransız edebiyat teorisyeni Tzvetan Todorov (1939-2017) tarafından yeni bir edebî türü karşılamak için öne sürülmüştür. Amerikan edebiyatında Henry James’in (1843-1916) Yürek Burgusu ile Türk edebiyatında Hüseyin Rahmi Gürpınar’ın (1864-1944) Ölüler Yaşıyorlar mı? romanı bu türün dikkat çeken örneklerindendir. Hayalet romanı olarak şöhret bulan iki eser, fantastik unsurların kullanımı bakımından büyük ölçüde birbirine benzemektedir. Bu incelemede fantastik türü hakkında kısaca bilgi verildikten sonra söz konusu eserler fantastik unsurlar bakımından karşılaştırılarak olay örgüsü, şahıs kadrosu, zaman, bakış açısı ve mekân gibi anlatı öğeleri bağlamında değerlendirilmeye çalışılmıştır. Ortaya konulan yorumları somutlaştırmak için de zaman zaman romanlardan alıntılara yer verilmiştir.
Instructor Perception of Incorporating Active Learning in College of Agriculture Classrooms
Authors: Karcher Elizabeth , Guberman Daniel , Bonem Emily , Lumkes John
Published: October 2022

Significant numbers of studies declare the effectiveness of “active learning” and numerous universities develop programs to support the incorporation of active learning methods, yet despite various incentives, adoption is met with resistance. This work shares the results of a study of instructor perceptions about active learning at a large research university in the United States. Instructor motivation, perceptions of competence and autonomy (related to colleagues and administrators), experience in training programs, as well as actual practices were explored with regard to active learning. Drawing on self-determination theory, this exploratory study will help universities in developing strategies for increasing the adoption of evidence-based teaching practices. Our results suggest that the work climate related to colleagues, gender, and participation in a Faculty Learning Community influenced both the implementation and motivation to implement active learning in the classroom.
Kualitas Pelayanan Surat Keterangan Catatan Kepolisian Online: Studi Kasus di Kepolisian Resor Sidoarjo
Authors: Wardana Aditya Eka
Published: October 2022

Abstract

This study aims to describe the quality of online police record certificate (SKCK) services with a case study at the Sidoarjo Resort Police. The service quality theory approach used is Parasuraman, Zeithml, Berry with five indicators, namely: tangible, reliability, responsiveness, assurance, and empathy. The method used in this research is descriptive qualitative research method. Data collection is done by observation, interviews, documentation. Determination of informants is determined by purposive sampling and then followed by the snowball technique. Check the validity of the data using data triangulation. Data analysis used qualitative analysis with stages, data reduction, data presentation, and conclusion drawing. The conclusion of the study is that the innovation of online SKCK services at the Sidoarjo Police is seen from the quality of services that run more efficiently and make it easier for the community.

Keywords: innovation, public service, service quality

 

Abstrak

Penelitian ini bertujuan mendiskripsikan kualitas pelayanan surat keterangan catatan kepolisian (SKCK) online dengan studi kasus di Kepolisian Resor Sidoarjo. Pendekatan teori kualitas pelayanan yang digunakan dari Parasuraman, Zeithml, Berry dengan lima indikator yaitu: tangible, reliability, responsiveness, assurance, dan emphaty. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif deskriptif. Pengumpulan data dilakukan dengan observasi, wawancara, dokumentasi. Penentuan informan ditentukan dengan purposive sampling lalu dilanjutkan dengan teknik snowball. Pemeriksaan keabsahan data menggunakan Triangaulasi data. Analisis data menggunakan  analisis kualitatif dengan tahapan, reduksi data, penyajian data, penarikan kesimpulan. Kesimpulan penelitian adalah inovasi layanan SKCK online di Polres Sidoarjo dilihat dari kualitas pelayanan berjalan dengan lebih efisien dan memudahkan masyarakat.

Kata kunci: inovasi, layanan publik, kualitas pelayanan
Tedaviye Dirençli Temporal Lob Epilepsili Olgularda Serum ve Bos’ta Otoantikorlar: Olgu Serisi
Authors: CANBAZ KABAY Sibel , TÜZÜN Erdem , AKDAĞ Gönül , ÇETİNER Mustafa , AYAS Selahattin , ÖZIŞIK KARAMAN Handan Işın , AKKOYUN ARIKAN Fatma
Published: October 2022

Nöbet önleyici ilaca(NÖİ) dirençli temporal lob epilepsili hastaların serum ve beyin omurilik sıvısı (BOS) analizinde nöronal antikor varlığını araştırmayı amaçladık. İlaca dirençli temporal lob epilepsisi tanısı ile izlenen, lomber ponksiyonu kabul eden 8 hastayı değerlendirdik. İlaca dirençli temporal lob epilepsisi nedeniyle takip ettiğimiz ve otoimmün epilepsi şüphesi duyduğumuz olgularda nöronal antikorları ve klinik özellikleri araştırdık. Tüm hastalarda hem serum hem de BOS'ta nöronal otoantikorlar negatif bulundu. BOS ve serum incelemelerinde nöronal antikorlar saptanmasa da bu durum çalışma grubumuzda epilepsi başlangıç yaşının erken olması ile ilişkili olabilir. Subakut bir klinik, nöbet sıklığının alışılmadık derecede yüksek olması, nöbetlerin çeşitliliği ve değişkenliği, NÖİ’lara direnç, kişide veya ailesinde otoimmün hastalık varlığı, kanser öyküsü veya viral prodrom varlığı, santral sinir sistemi inflamasyonun gösterilmesi, nöral antikorların varlığında Otoimmün epilepsi ayırıcı tanıda düşünülmelidir.
Capitalism is Ending, but
Authors: Fishman L.
Published: October 2022

This article attempts to answer the question: is the description of Modernity in terms of “capitalism” justified? The author shows that during the history of the 20th‑21st centuries, the pictures of capitalism drawn by theorists got more and more atypical elements. Among these are the theories of imperialism, dependent development, a single industrial society, and especially the world-system analysis. Also noteworthy is the description “modern” applied to the societies of this period. A situation has arisen where many phenomena fit into the concept of “capitalism”, or “capitalism with numerous prefixes”. Thus, “capitalism” in various guises becomes “too much”. Eventually, capitalism itself has come down to the universal phenomena of violence, inequality and exploitation. The productivity of discussing modernity in a paradigm revolving around the notion of “capitalism” is becoming less and less obvious. Too wide range of practices has become associated with “capitalism with prefixes”, which forced a number of researchers to refuse to identify modernity with capitalism in favor of various concepts based on retro-metaphors (“neo-feudalism”). Numerous concepts of “post-capitalism” have also emerged. The author substantiates that at the theory layer, the difference between the types of what is still interpreted as “capitalism” or already as “post-capitalism” does not have a qualitative character. Of all the aforesaid, the marxian concept of human “prehistory” becomes relevant as a more universal paradigmatic frame for comprehending modern trends. Therefore, the concept of communism will still remain a worldview horizon that gives a meaning to this “prehistory”. In a situation where capitalism ends, but “prehistory” does not, this will make it possible to single out social relations that determine the “prehistory” nature by themselves, and not through the prism of denouncing or apologizing (which is “capitalism” initially) of their political discourses.
Modern Ideological Challenges to the Rule of the CPC
Authors: Lomanov A.
Published: October 2022

China’s ability to regulate and control the situation in the ideological sphere has increased markedly during the recent decade. At the same time, Chinese society is becoming more and more diverse, which makes social thought more and more heterogeneous. The article focuses on the changes that have taken place in relations between the ideology of CPC and non-official trends of thought. Through publications of Chinese researchers the article analyzes the key aspects of the CPC policy aimed at strengthening the leadership of the official ideology and preventing radicalization of public sentiment. In China experts are especially concerned about the ability of non-mainstream ideas to challenge the “national ideological security”. The increase in the influence of official ideology led to weakening of neo-liberalism, universal values, and historical nihilism. However, the mode of interaction between the official ideology of the CPC and other ideological currents cannot be reduced to confrontation between “Chinese authoritarianism” and “Western liberalism”. The full picture can be seen only by taking into account the complex relationship of Party ideology with the diverse ideas of the “gray” zone. Intense debates in China are focused on trends that have no clear theoretical basis and political orientation, but are capable to mobilize masses and radicalize public sentiment. The authorities search for optimal response to outbursts of radical Internet-populism while seeking to put nationalism and consumerism into reasonable limits. The reaction of Chinese society to the coronavirus epidemic has demonstrated that at a time of crisis and decrease in people’s confidence in the effectiveness of the work of the state there was an explosive growth of pro-Western and populist sentiments. The task of combining the leading role of the normative ideology of the CPC with the diversity of social ideas will remain relevant over a long time.
Cooperation Prospects in Eurasian Region in the Context of the Biological Weapons Convention
Authors: Malygina A. , Zavriev S.
Published: October 2022

The BТWC was drafted in the late 1960s with a primary focus on the prohibition of biological weapons. In the 50 years that have passed since the Convention entered into force in 1972, the life sciences, genetic, pharmaceutical and biomedical technologies have stepped forward in their evolution and reached an unprecedented level of development. However, the BТWC is still the only multilateral agreement that provides rich opportunities for solving problems in the field of global biosecurity, including but not limited to the issues of preventing the use of the achievements of biological and medical sciences for purposes harmful to human health, animals and plants. The implementation of the provisions of the Convention at the national and regional levels should help to minimize a wide range of biological risks. At present, Russia pays special attention to further development of regional cooperation on biosecurity with the countries of Eurasian region. Such partnership, on the one hand, creates opportunities for strengthening the BTWC regime, and on the other, it contributes to onward elaboration of plans for scientific and technical cooperation with neighboring states, which is important for improving joint strategies of responding to emerging biosecurity risks, preventing the spread of infectious diseases, and comprehensively strengthening economic and technological potential of Eurasia. The paper provides an overview of Russia’s efforts aimed at building the partnership biosecurity network in the Eurasian region. By the middle of 2022, Russia has concluded memorandums of understanding in the field of biosecurity with four participants of the Commonwealth of Independent States (Armenia, Uzbekistan, Tajikistan, Turkmenistan) and expects to sign extra four agreements (with Belarus, Kazakhstan, Kyrgyzstan and Azerbaijan). The authors analyze Russian official narrative related to the BTWC and biosecurity, summarize Russia’s expectations about the regional cooperation in this field, and suggest some recommendations on practical steps to make this cooperation sustainable and mutually beneficial for all the participants including Russia. The paper presents a detailed analysis of prospects for further strengthening the regional cooperation in the context of the BТWC in such multilateral formats as the Collective Security Treaty Organization, the Commonwealth of Independent States, and the Shanghai Cooperation Organisation.
"Hidden Life on Your Hands": Teacher's Guide
Authors:   University of Dundee, Stanley-Wall Nicola , Carneiro Joana ,   University of Dundee
Published: October 2022

The “Hidden Life on your Hands” video is the result of a public engagement activity with schoolchildren aged 11 and 12, and introduces children to basic concepts of microbiology, highlighting the diversity of microbial life present on our hands normally invisible to the naked eye. This was created by the Stanley-Wall laboratory based in the Division of Molecular Microbiology at the University of Dundee.
Evaluación de la exposición a arsénico y factores de riesgo de aterogénesis en una población Altoandina en Perú
Authors:   Yadira Fernández Jerí Grupo de investigación Bioquímica Toxicológica, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos, Lima, Perú, Fernández Jerí Yadira , Benavides Rivera Elena Rafaela ,   Grupo de investigación Bioquímica Toxicológica, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos, Lima, Perú, Dávila Espinoza Cristopher Emanuel ,   Grupo de investigación Bioquímica Toxicológica, Facultad de Farmacia y Bioquímica, Universidad Nacional Mayor de San Marcos, Lima, Perú, Gonsebatt María E. ,   Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, México, del Razo Luz M. ,   Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Ciudad de México, México
Published: October 2022

La exposición a arsénico (As) a través del agua de consumo es una problemática mundial que afecta a varias áreas geográficas. Sin embargo, la información relacionada con su exposición y sus efectos en Perú es limitada. Con el objetivo de estimar la relación entre la exposición a As y los factores de riesgo de aterogénesis en residentes de Jauja, Perú (3390 msnm), se realizó un estudio transversal en residentes de Apata (n = 31) y Molinos (n = 81) que consumían agua con concentraciones de As entre 5 y 47 µg/L, respectivamente. Se evaluaron las concentraciones de As en agua y orina por espectrofotometría de absorción atómica con generación de hidruros, además del perfil lipídico, la actividad arilesterasa de la paraoxonasa 1 (PON-ARE), la presión arterial y los niveles de glucosa en ayunas (Glu). En el estudio participaron 112 adultos de 18 a 81 años de edad. La mediana de las concentraciones de As total en orina (AsT-U) fue de 4.4 y 28.5 µg/L para Apata y Molinos, respectivamente. Según el análisis de regresión lineal múltiple por pasos, la disminución de la actividad PON-ARE y las concentraciones de colesterol no HDL estuvieron relacionadas con mayor concentración de AsT-U (Apata: β = –0.26, IC de –0.93 a –0.17, R2 = 0.07, p < 0.001; Molinos: β = –0.38, IC de –0.797 a –0.295, R2 = 0.15, p < 0.001). Por otra parte, se observó un aumento de Glu a mayor concentración de AsT-U (β = 0.22, IC de 0.09 a 0.35, R2 = 0.09, p < 0.05). Los resultados sugieren que la exposición a As puede aumentar el riesgo de aterogénesis en la población de Molinos Jauja, Perú.
The Role of Age to Sustainable Fast Fashion Consumption Behaviour: An Empirical Study of Chinese Consumers
Authors: Cao Yanghui
Published: October 2022

Previous studies implied the different behavioral intention formation of a specific object for individuals in different age groups, but few research to Chinese consumers’ sustainable fast fashion behaviour were found considering the enormous amount of consumption and waste of fast fashion products in China. Meanwhile, as a fast developing country, it might be insufficient to conduct research ignoring the consequences of different education level and growing environment among different generations. Thus, to generate in-depth and heuristic Chinese consumers information, this study developed proposed theoretical framework (TORA) based on research by Fishbein and Ajzen (1975), while the validity among Chinese consumers was tested as well. Following the TORA model, this study aims to investigate if consumers’ age will moderate the relationship between attitude and intention, and the relationship between subjective norms to behavioral intention. Through structural equation modelling in AMOS, it was found that the model has a well fit to large sample of Chinese consumers, while the moderation effect of age was not significant in the whole sample. Further hierarchical regression analysis conducted in SPSS and Process was able to locate the moderation effect of if divide the consumers into groups by age. Which is, age is significantly and positively moderating the path subjective norms to intention in younger generation (18-25), but significantly positive moderating attitude to intention in consumers aged 26-39. Implications in marketing and to policy makers are discussed at the end of this research.
Incoherence of Deep Isotropic Neural Networks increase their performance on Image Classification
Authors: Feng Wenfeng , Zhang Xin , Song Qiushuang , Sun Guoying
Published: October 2022

Although neural network architectures are critical for their performance, how the structural characteristics of a neural network affect its performance has still not been fully explored. We here map architectures of neural network to directed acyclic graphs, and find that incoherence, a structural characteristic to measure the order of directed acyclic graphs, is a good indicator for the performance of corresponding neural networks. Therefore we propose a deep isotropic neural network architecture by folding a chain of same blocks then connecting the blocks with skip connections at different distances. Our models, named FoldNet, have two distinguishing features compared with traditional residual neural netowrks. First, the distances between block pairs connected by skip connections increase from always equal to one to specially selected different values, which lead to more incoherent graphs and let the neural network explore larger receptive fields and thus enhance its multi-scale representation ability. Second, the number of direct paths increases from one to multiple, which leads to a larger proportion of shorter paths and thus improve the direct propagation of information throughout the entire network. Image classification results on CIFAR-10 and Tiny ImageNet benchmarks suggested that our new network architecture performs better than traditional residual neural networks.
Estimating the Burden Among Informal Caregivers of Stroke Survivors in East Coast Peninsular Malaysia: A Short-Term Longitudinal Study
Authors: Bin Suliman Mohd Azmi , Chen Xin Wee , Ibrahim Mohd Ismail , Musa Kamarul Imran , Hamzah Nurfaten , Nadal Iliatha Papachristou , Mustapha Feisul Idzwan , Abdul Rahim Mohd Zulkifli , Sidek Norsima Nazifah , Abdullah Jafri Malin , Kamalakannan Sureshkumar
Published: October 2022

Taking care of stroke survivors can be taxing, however, it was understudied in Malaysia. This study aims to describe the burden of informal stroke caregivers within three months after hospital discharge. A longitudinal study design was conducted. Acute stroke survivors and their informal caregivers were recruited prior to hospital discharge, and the caregivers were interviewed by phone. Self-reported caregiver burdens were measured with Zarit Caregiver Burden Interview – Malay version (MZBI) and Caregiver Assessment of Function and Upset – Malay version (Malay-CAFU). The MZBI and Malay-CAFU scores were collected four times within three months. A total of 85 stroke survivors and 155 informal caregivers were recruited, with 58.1% of the caregivers were female. The stroke survivors had two caregivers on average. The mean (SD) scores for the three scales show a reduction, from 27.42 (12.73) in the first week to 17.77 (11.20) in the third month for MZBI, from 1.14 (0.94) to 0.62 (0.64) for instrumental activities of daily livings (IADL) of Malay-CAFU upset scale and 1.36 (1.00) to 0.78 (0.65) for activities of daily living (ADL) of Malay-CAFU upset scale in the same period. Stroke survivors may have several caregivers, usually their spouses or children. Within a short period, the caregiver’s burden was reduced. Early psychosocial support to alleviate the caregiver burden may be necessary.
Extracellular Secretomes of Leptospira Interrogans Serovar Icterohemorrhagiae Respond to the In Vivo Mimic of Physiological Osmolarity and Temperature Transition
Authors: Thiangtrongjit Tipparat , Reamtong Onrapak , Phumratanapraphin Weerapong , Limmathurotsakul Direk , Chatpun Surapong , Odton Mingkwan , Vanaporn Muthita , Pumirat Pornpan , Boonyuen Usa , Ampawong Sumate , Soonthornworasiri Ngamphol , Adisakwattana Poom , Chaisri Urai , Maneewatchararangsri Santi
Published: October 2022

Leptospirosis remains an important worldwide zoonotic disease caused by Leptospira spp affecting human and animals. This research aims to study the virulent-associated secreted proteins (protein secretome) of pathogenic Leptospira interrogans serovar Icterohemorrhagiae strain RGA (Leptospira RGA) transition from the environment to mammalian physiological osmolarity, temperature (37 °C) and carbon dioxide concentration (5% CO2) conditions for 24 h. Mass Spectrometry and bioinformatics approaches, we identified 69 potential secreted proteins from the culture supernatant of the Leptospira RGA isolate. We discovered transporters and porins such as phosphate porin, outer membrane efflux, ompA family protein, and polymer-forming cytoskeletal family protein under hyperosmotic condition. Under heat stress, degradation enzymes included zinc metallopeptidase, M23 family (LA3456, LA0709), Rhs family protein (LA1765), thermolysin metallopeptidase; / hydrolase family (LA1345, LA2501). Oxidative stress response proteins induced by osmolarity and temperature shifts included chaperon GrpE, DnaK (LA3705), antioxidants, i.e., thiol-specific redoxin, and peroxiredoxin (LA2809). In response to the in vivo transition, metabolic and other enzymes involved in energy production (COG:C), amino acid metabolism and transport (COG:E), and lipid metabolism and transport (COG:I), as well as moonlighting proteins functionally binding to plasminogen and fibronectin and regulating transcription, were also discovered. An overview of secreted proteins will supplement our understanding of Leptospira biology and pathogenesis during infection and also in response to environmental stimuli and their potential virulent determinants have the potential for developing leptospirosis vaccines and diagnosis.
Can a Two-Dose Influenza Vaccine Regimen Better Protect Older Adults? An Agent-Based Modeling Study
Authors: Williams Katherine V. , Krauland Mary G. , Harrison Lee H. , Williams John V. , Roberts Mark S. , Zimmerman Richard K.
Published: October 2022

Older adults (age ≥65) are at high risk of influenza morbidity and mortality. This study evaluated the impact of a hypothetical two-dose influenza vaccine regimen per season to reduce symptomatic flu cases by providing preseason (first dose) and mid-season (second dose) protection to offset waning vaccine effectiveness (VE). The Framework for Reconstructing Epidemiological Dynamics (FRED), an agent-based modeling platform, was used to compare typical one-dose vaccination to a two-dose vaccination strategy. Primary models incorporated waning VE of 10% per month and varied influenza season timing (December through March) to estimate cases and hospitalizations in older adults. Additional scenarios modeled reductions in uptake and VE of the second dose, and overall waning. In seasons with later peaks, two vaccine doses had the largest potential to reduce cases (14.4% with February peak, 18.7% with March peak) and hospitalizations (13.1% with February peak, 16.8% with March peak). Reductions in cases and hospitalizations still resulted but decreased when 30% of individuals failed to receive a second dose, second dose VE was reduced, or overall waning was reduced to 7% per month. Agent-based modeling indicates that two influenza vaccine doses could decrease cases and hospitalizations in older individuals. The highest impact occurred in the more frequently observed late-peak seasons. The beneficial impact of the two-dose regimen persisted despite model scenarios of reduced uptake of the second dose, decreased VE of the second dose, or overall VE waning.
Perspectives on Using Connected Vehicles for Transportation Infrastructure Condition Monitoring
Authors: Bridgelall Raj
Published: October 2022

The condition of surface transportation infrastructure directly affects the economic health of a nation. However, it is difficult to justify the large sums of money needed to extend current methods to monitor all the multimodal infrastructure. The convergence of connected vehicle and cloud computing technologies presents an opportunity to automate the collection of ride quality and imagery data to continuously assess the condition of all roadways and railways. This paper presents several perspectives to help policy and standardization initiatives promote adoption.
Advanced Analysis of Electroretinograms Based on Wavelet Scalogram Processing
Authors: Zhdanov Aleksei , Dolganov Anton , Zanca Dario , Borisov Vasilii , Ronkin Mikhail
Published: October 2022

The electroretinography (ERG) is a diagnostic test that measures the electrical activity of the retina in response to a light stimulus. This test has a long history and has been extensively studied among years. Dr. James Dewar recorded the first electroretinogram signal in 1873. Later he described signal analysis using 4 components, namely amplitude, and latency of a-wave and b-wave. Nowadays, the international electrophysiology community has established the standard for electroretinography in 2008. However, from the point of view of signal analysis, the major change did not happen. ERG analysis is still based on the 4 components evaluation. The article describes ERG database including the classification of signals by using advanced analysis of electroretinograms based on wavelet scalogram processing. To implement an extended analysis of the ERG, the parameters extracted from the wavelet scalogram of the signal were obtained using digital image processing and machine learning methods. The results of the study show that the proposed algorithm implements the classification of adult electroretinogram signals by 19% more accurately and pediatric signals by 20% more accurately than the classical algorithm. The promising use of ERG is differential diagnostics, which may also be used in preclinical toxicology and experimental modeling. The problem of developing methods for electrophysiological signals analysis in ophthalmology is associated with the complex morphological structure of electrophysiological signals components, due to the generation of retina cell electrical responses to light stimulus.
Incomplete Diaphyseal Atypical Femoral Fracture due to Increased Anterolateral Bowing
Authors: Yoon Yong-Cheol , Oh Chang-Wug , Oh Jong-Keon , Kim Joon-Woo , Park Kyeong-Hyeon , Song Hyung Keun
Published: October 2022

Background:

Increased anterolateral bowing of the femur is associated with atypical femoral fractures among older patients (including both those receiving and those not receiving treatment with bisphosphonates) as well as a greater likelihood of occurring in the diaphyseal versus the subtrochanteric region. Prophylactic intramedullary (IM) nailing is recommended for the treatment of incomplete atypical femoral fractures, which are radiographically evident. However, this bowing deformity is considered to be a major obstacle to IM nailing as it may be associated with postoperative complications. Corrective osteotomy combined with IM nailing straightens the exaggerated curvature of the femur. We hypothesized that this technique may lead to the safe and rapid healing of incomplete diaphyseal atypical femoral fractures, thereby reducing lateral tensile stress.

Methods:

From October 2015 through March 2020, 17 female patients (20 femora) with a mean age of 76.1 years (range, 68 to 86 years) underwent a surgical procedure for the treatment of an incomplete diaphyseal atypical femoral fracture associated with anterolateral bowing. The surgical technique consisted of minimally invasive osteotomy and reconstruction with use of IM nailing, with or without an augmentation plate. Preoperative and postoperative radiographic findings (lateral and anterior bowing angles, anterolateral bowing grade, and lateral distal femoral angle [LDFA]) were compared. Primary union, time to union, and complications were evaluated as the outcomes.

Results:

Primary bone union was achieved in 19 of the 20 femora at a mean of 24.9 weeks (range, 20 to 40 weeks). There were 2 instances of delayed union, which healed at 36 and 40 weeks. The lateral bowing angle, anterior bowing angle, and LDFA significantly improved postoperatively (from 12.0° to 3.3°, from 17.3° to 11.5°, and from 93.5° to 88.8°, respectively) (p < 0.001). There was 1 instance of nonunion, which healed after plate augmentation without a bone graft.

Conclusions:

Given the pathophysiology of elevated lateral tensile stress, corrective osteotomy and IM nailing may be an acceptable solution for the treatment of incomplete diaphyseal atypical femoral fractures associated with increased anterolateral bowing.

Level of Evidence:

Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
Femoral Stem Cementation in Primary Total Hip Arthroplasty
Authors: El-Othmani Mouhanad M. , Zalikha Abdul K. , Cooper H. John , Shah Roshan P.
Published: October 2022

» Femoral stem cementation has undergone considerable investigation since bone cement was first used in arthroplasty, leading to the evolution of modern femoral stem cementation techniques.

» Although there is a worldwide trend toward the use of cementless components, cemented femoral stems have shown superiority in some studies and have clear indications in specific populations.

» There is a large evidence base regarding cement properties, preparation, and application techniques that underlie current beliefs and practice, but considerable controversy still exists.

» Although the cementing process adds technical complexity to total hip arthroplasty, growing evidence supports its use in certain cohorts. As such, it is critical that orthopaedic surgeons and investigators have a thorough understanding of the fundamentals and evidence underlying modern cementation techniques.
RESPONSABILIDADE PROFISSIONAL POR LESÃO DO NERVO LINGUAL PÓS-EXODONTIA DE TERCEIRO MOLAR INFERIOR: ANÁLISE DE NOVE PROCESSOS JUDICIAIS
Authors: Silva José Lucas Santos , Rodrigues Lívia Graziele , Coltri Marcos Vinícius , Goulart Douglas Rangel , Garcia Robson Rodrigues , Silva Rhonan Ferreira
Published: October 2022

Introdução: A remoção cirúrgica dos terceiros molares inferiores apresenta o risco potencial de lesões a estruturas nobres como o nervo lingual devido sua localização anatômica. O grau de comprometimento do nervo indicará se a lesão é transitória ou permanente. A injúria nervosa pode motivar o paciente a acionar judicialmente o cirurgião-dentista, e sendo evidenciada a culpa profissional, caberá a reparação pecuniária dos danos causados ao paciente, sejam de natureza material ou moral. Objetivo: Analisar nove decisões judiciais de 1ª e 2ª instância, disponíveis no site do Tribunal de Justiça de São Paulo (TJSP), motivadas pela lesão do nervo lingual durante a exodontia de terceiro molar inferior. Metodologia: Após a leitura e análise foram extraídas informações como: perfil das partes, tempo de duração dos processos, procedência ou não da ação, valor da indenização, responsabilidade profissional presença de TCLE. Resultados: Houve a improcedência, em primeira instância, de seis dos nove casos, a sentença foi reformada em quatro processos, confirmando-se a procedência da ação em sete dos nove casos. Nas ações procedentes, as indenizações para dano moral variaram de R$ 5 mil a R$ 50 mil, sendo a imperícia e negligência as modalidades de culpa mais atribuídas aos profissionais. Conclusão: Sabendo-se que a lesão do nervo lingual durante a extração de terceiro molar inferior, mesmo previsível, nem sempre é evitável, verifica-se a importância do TCLE (ou documento similar) na prática clínica como instrumento de defesa jurídica do profissional, diante da alegação de falha de informação. Este documento foi mencionado em apenas três dos nove casos processuais, sendo em que em dois destes não houve constatação de falha técnica ou de informação (ação improcedente nas duas instâncias).
EDITORIAL
Authors: Silva Ricardo Henrique Alves da
Published: October 2022

BOCA DE URNA

 

Pesquisa boca de urna indica: a RBOL – Revista Brasileira de Odontologia Legal tem 100% da preferência na leitura entre os profissionais que militam na Odontologia Legal.

É claro que inicio esse editorial com essa brincadeira... Mas o momento em nosso país é sério! Afinal, exercer o direito/dever ao voto demanda muita responsabilidade! Estamos em pleno processo eleitoral, a verdadeira festa da democracia em nosso país, onde temos o dever de escolher nossos mandatários para os cargos de Presidente, Governador, Senador, Deputado Estadual e Deputado Federal. Assim, por tão importante momento, fica o pedido (que é “chavão”, mas vale reforçar): vote consciente!

E em meio a todo esse agito democrático, aí está mais uma edição da nossa RBOL e, também, no mesmo espírito democrático, afinal são dez artigos, nos mais variados temas da nossa bela especialidade. Então, entre um debate e outro... Entre primeiro turno e segundo turnos... Fica a dica de aproveitar cada um dos importantes textos que aqui encontra.

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Identification of twin shaft gas turbine based on hybrid decoupled state multiple model approach
Authors: Aissat Sidali , Hafaifa Ahmed , Iratni Abdelhamid , Guemana Mouloud
Published: October 2022

The work presented in this paper focuses on presenting an hybrid identification method for a nonlinear dynamic gas turbine, from a real time input and outputs data exploitation, with the fuel flow as the input and the rotational speed of high pressure and low pressure turbine as outputs. The multi model, which are in the form of a weighted combination of local linear state space models, offer an interesting alternative of the nonlinear models because it takes into account a several operating modes. The models are identified with the help of decoupled models using a hybrid approach between parametric estimation using artificial intelligence algorithms.
Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice
Authors: Barjoan Eugènia Mariné , Chaarana Amel , Festraëts Julie , Géloen Carole , Prouvost-Keller Bernard , Legueult Kévin , Pradier Christian
Published: October 2022

Introduction: Socio-demographic factors are known to influence epidemic dynamics. The town of Nice displays major socio-economic inequalities, with over 50% of the population living below the poverty threshold in some districts. Objective: To measure the association between the incidence of SARS-CoV-2 and various factors related to social inequality in Nice during the first 6 weeks of 2021. Material and Methods: The study included residents of Nice with a first positive SARS-CoV-2 test (January 4 - February 14, 2021). Data were provided by the National information system for Covid 19 screening (SIDEP), and socioeconomic data were obtained from the National Institute of Statistics and Economic Studies (INSEE). Each case’s address was allocated to a census block to which we assigned a social deprivation index categorized into 5 classes. For each category, we calculated the incidence rate per age, per week and for the overall study period and the Standardised Incidence Ratio between the most deprived category compared to the remaining categories. We then calculated the Pearson’s correlation coefficient between the number of cases and each of the socio-economic variables within these blocks. To characterise the effect of the association of all these variables on the incidence rate, these were included in a Generalized Additive Model with a Poisson distribution. Results: We included 10 078 cases. The highest incidence rate was observed in the most socially deprived areas for each age group (2 669 to 4 901 cases /100 000 inhabitants). The number of observed cases in the worst level of social deprivation category (N = 2019) was significantly higher than expected (N = 1384) SIR = 1.46 [1.40–1.52], p < 0.001. Several socio-economic variables related to housing, work and income were correlated with the number of cases. In the Generalized Additive Model, we found a correlation between the indicators and the more deprived populations (density, overcrowded housing, poverty rate, certain occupations and uneducated populations). Conclusion: Local surveillance of epidemics provides complementary data to national and regional surveillance. Mapping socio-economic vulnerability indicators at the census block level and correlating these with incidence rates could prove highly useful to guide political decisions in public health.
Integrating omics reveals that miRNA-guided genetic regulation on plant hormone level and defense response pathways shape resistance to Cladosporium fulvum in the tomato Cf-10-carrying line
Authors: Liu Guan , Zhang Dongye , Zhao tingting , Yang Huanhuan , Jiang Jingbin , Li Jingfu , Zhang He , Xu Xiangyang
Published: October 2022

Invasion of Cladosporium fulvum causes the most serious diseases affecting the reproduction of tomatoes. Cf-10 gene carrying line showed remarkable resistance to C. fulvum. To exploit its defense response mechanism, we performed a multiple-omics profiling of Cf-10-carrying line and a susceptible line without carrying any resistance genes at control and 3 days postinoculation (dpi) of C. fulvum. We detected 54 differentially expressed miRNAs (DE-miRNAs) between the control and 3 dpi in the Cf-10-carrying line, which potentially regulated plant–pathogen interaction pathways and hormone signaling pathways. We also revealed 1,100 differentially expressed genes (DEGs) between the control and 3 dpi in the Cf-10-carrying line whose functions enriched in pathways that were potentially regulated by the DE-miRNAs. Integrating DE-miRNAs, gene expression and plant-hormone metabolites demonstrated a regulation network where the down-regulation of miRNAs at 3 dpi activated crucial resistance genes to trigger host hypersensitive cell death, improved hormone levels and upregulated the receptors/critical responsive transcription factors (TFs) of plant hormones, to shape immunity to the pathogen. Notably, we identified and expressionally validated that the downregulation of miR9472 would upregulate the expression of IAA-LEUCINE RESISTANT (ILR)-LIKE GENE 6 (ILL6), a gene that transforms JA to its major active component (+)-7-iso-jasmonoyl-l-isoleucine (JA-Ile), to improve the level of JA-Ile and activate JA-response genes in the Cf-10-carrying line. Our results demonstrated regulatory network and potential new pathway underlying the resistance to C. fulvum in Cf-10 gene carrying line, providing a more comprehensive genetic circuit and valuable gene targets for modulating resistance to the virus.
Construction of a prediction model of cancer-specific survival after ovarian clear cell carcinoma surgery
Authors: Huang Mengqi , Ling Li , Liu Yanbo , Li Yujuan
Published: October 2022

Purpose
To construct a nomogram model for predicting postoperative cancer-specific survival (CSS) of patients with ovarian clear cell carcinoma (OCCC) and analyze in detail the risk factors associated with OCCC.
Methods
The clinical pathological data of 596 OCCC patients were collected from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2015. Of these patients, 420 were allocated to the training group and 176 patients to the validation group using bootstrap resampling. The nomogram was developed based on the Cox regression model for predicting the cancer-specific survival probability of patients at 3 and 5 years after the operation. The model was evaluated in both the training and validation groups using consistency index, Receiver Operating Characteristic (ROC), and calibration plots.
Results
The independent risk factors for CSS in OCCC patients included FIGO stage, race, age, tumor laterality, and the log odds of positive lymph nodes (LODDS). The nomograms were established for predicting the 3- and 5-year CSS of patients after operation. The c-index of the nomogram for CSS was 0.786 in the training group and 0.742 in the verification group. AUCs of the 3-year and 5-year ROC curves were 0.818, 0.824 in the training group; and 0.816, 0.808 in the verification group, respectively.
Conclusion
Based on the real population data, the construction of the CSS prediction model after OCCC surgery has high prediction efficiency, can identify postoperative high-risk OCCC patients, and can be a valuable aid for the tumor staging system.
Human Resource for Health Gaps in Nigeria: Stakeholders’ Policy Considerations Towards Accelerating Universal Health Coverage in Nigeria
Authors: Azodoh Ngozi Rosemary , Obitube KelvinFrancis
Published: October 2022

Introduction and objectives:
This study discussed issues relating to human resources for health that have impacted the advancement of access to healthcare for all Nigerians, as well as the policy considerations towards ameliorating these challenges. The objectives were to assess the current challenges of HRH towards enhancing Nigeria’s health workforce for the attainment of Universal Health Coverage and to discuss the current considerations of health policy makers towards enhancing Nigeria’s health workforce for the attainment of Universal Health Coverage
Materials and methods
The study employed the qualitative research method and adopted the descriptive survey design. A review of government documents, key informant interviews, participant observation and shared experiences were instruments for data collection. It then employed the descriptive method of analysis.
Results
The study established inadequate funding as a huge challenge to the health sector, and this also impacts on the working conditions of healthcare workers. It also highlighted the non-implementation of skills-gap analysis for determining the recruitment and distribution of healthcare personnel as a tangible contributor to addressing skilled health workforce gaps. Political, ethno-cultural and religious sentiments and practices were also highlighted as challenges impacting the delivery of financial access to healthcare for all Nigerians.
Conclusion
Aside advocating a holistic policy approach for addressing healthcare workforce gaps in the National Health System, the study supports the need for more professionals in communication to better orientate Nigerians towards understanding and embracing healthcare insurance. This will be geared towards accelerating Universal Health Coverage whilst ensuring financial access for all.