bluuebunny/crossref_metadata_2025 huggingface dataset:
Dynamic Colormap Visualization Integratedwith Harris Hawks Optimization for EnhancedLung CT Segmentation and Diagnostic Precision
Authors: Dorgham Osama , Ryalat Mohammad , Najdawi Nijad , Alkhawaldeh Rami , AlShaqsi Jamil , Al-Betar Mohammed
Published: November 2024

This study presents a novel method that utilizes Harris Hawks Optimization (HHO) combined with dynamic colormap visualization to enhance the quality of lung CT scan segmentation. The Harris Hawks optimization algorithm is a swarm-based method used to enhance multi-level thresholding for image segmentation, hence facilitating the identification of regions of interest (ROIs) in medical images. An analysis of different colormap schemes, including Accent, Gray, Hot, Inferno and Jet, was conducted to improve the visualization of segmented images.The experimental results show the efficiency of the HHO algorithm from the segmentationaccuracy perspective as compared to the conventional optimization techniques using publicly available datasets from the Cancer Imaging Archive. In particular, the average SSIM was above 98% while the Jaccard Index was more than 90%. The expert evaluation confirms earlier findings that using the HHO algorithm with the Inferno colormap, particularly with four or five thresholds, achieves optimal image clarity and diagnostic value for clinical purposes. In addition, the method provides a promising way to enhance diagnostic precision and treatment strategies for lung diseases, making it highly valuable for pulmonaryhealthcare, particularly in urgent scenarios such as pandemics.
The burden of shift schedules: development and theoretical cross-validation of the Shift Load Index for optimised recovery and emergency department planning
Authors: SCHMIDT Laura , PEREZ Clément , VALERO Bérénice , SCHLATTER Sophie , FRATICELLI Laurie , TAZAROURTE Karim , MAZZA Stéphanie , DOUPLAT Marion
Published: November 2024

Background Healthcare workers in emergency departments work during atypical hours, which can lead to disturbances in the sleep-wake rhythm and provoke a high risk of sleepiness during stressful working hours. We developed and tested an adapted, simplified index to predict the recovery limitations exclusively relying on work schedules.Methods We conducted a retrospective observational multisite study. 140 shifts by 55 healthcare workers across two emergency departments were included. We calculated a Shift Load Index for each day, using the previous two weeks' schedules to assess the recovery limitations of different work patterns. The Shift Load Index rating contains nine items with three levels of risk: half of the maximum score 18 is the cut-off score for a heightened risk. We compared the Shift Load Index ratings with the existing biomathematical model Fatigue Audit InterDyne (FAID)), a commercial tool established in heavy industries, and with the auto-evaluation of instant sleepiness (Karolinska Sleepiness Scale).Results The average Shift Load Index amounted to 6.07 (± 3.14) and varied between 0 to 13, while 21% of shifts were rated at heightened risk and 2% at zero risk. The Shift Load Index did not differ between physicians and nurses. The Shift Load Index was a significant predictor of FAID scores (peak FAID FATIGUE, p < 0.000; peak FAID ALERTNESS, p = 0.047).Conclusions The Shift Load Index offers a promising avenue for assessing workload and recovery limitations in emergency department settings, facilitating targeted planning at both individual and team levels. Its correlation with established models encourages further validation through expanded studies.
Ketoprofen loaded β-Cyclodextrin complexation for enhancing solubility of BCS Class II Drugs.
Authors: Doshi Mitali , Kakade Prajakta , Deshmukh Tejeswini , Gandhi Ravikiran , Mali Kiran
Published: November 2024

Ketoprofen is the most widely used non-steroidal anti-inflammatory drug (NSAID) which comes under BCS Class II, making it effective for relieving pain and inflammation. However, despite its therapeutic benefits, Ketoprofen has low aqueous solubility, which significantly hinders its oral bioavailability. This limitation highlights the need for innovative strategies to improve its absorption in the body. One promising approach involves forming cyclodextrin inclusion complexes, which act as a specialized delivery system for drugs with poor solubility. In our study, we focused on synthesizing Ketoprofen/ β- cyclodextrin inclusion complexes using microwave irradiation, with molar ratios of 1:1 and 1:2. The main goal of our research is to investigate how these β-cyclodextrin complexes affect the solubility and bioavailability of Ketoprofen. To thoroughly evaluate the effectiveness of this novel system, we will examine various parameters, including the percentage of practical yield. This will be carried out using exacting laboratory techniques such as in-vitro drug dissolution investigations, differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FTIR). We will also assess drug content uniformity to ensure a comprehensive analysis of how these complexes enhance the properties of ketoprofen.
A Mixed-methods Approach to Investigating Chinese English Majors’ Writing Self- Efficacy, Writing Self-Regulated Learning Strategies and Writing Proficiency
Authors: Zhu Peiqi , Sun Xiaohui
Published: November 2024

Writing self-efficacy and writing self-regulated learning (SRL) strategies are pivotal factors influencing writing proficiency from the social cognitive perspective. This study used a mixed-methods design to investigate theirrelationships among English majors in the Chinese English as a Foreign Language (EFL) context. The study was conducted in two stages. In Stage One, quantitative data were collected from 73 English major sophomores at a key university in Beijing through cluster sampling. Participants completed two self-reported questionnaires assessing writing self-efficacy and writing SRL strategies, alongside a timed writing proficiency test. Stage Two involved qualitative data collection, where four students from both low and high proficiency groups were purposefully selected for think-aloud protocols and retrospective semi-structured interviews. The results revealed significant positive correlations between writing self-efficacy, writing SRL strategies and writing proficiency. Notably, there were substantial differences in writing self-efficacy and writing SRL strategy use between high and lowproficiency writers, particularly in the use of English writing self-efficacy and environmental SRL strategies. Moreover, writing self-efficacy accounted for 24% and writing SRL strategies for 9.9% of the variance in writing proficiency. The writers’ perceptions and possible mechanisms were provided as supplementary. Implications for language instructors and EFL learners are discussed in the end.
Profiling current cancer survivorship practices and enhancing survivorship care in public hospitals in Victoria, Australia
Authors: Nash Tegan , Lisy Karolina , Laing Erin , Kelly Helana , Cridland Kate , Jefford Michael
Published: November 2024

Purpose
Comprehensive survivorship care involves cancer surveillance, management of post-treatment effects, health promotion, and coordination between care sectors. This study aimed to understand current survivorship practices, build awareness, and support improved survivorship care in Victoria, Australia.
Methods
This project had three components: (1) a survey of 20 Victorian clinical sites, assessing elements described in the Victorian Quality Cancer Survivorship Framework; (2) educational webinars for oncology health professionals, to increase survivorship knowledge and awareness, (3) implementation of targeted survivorship care quality initiatives in a sample of health services. Survey, evaluation and outcome data were reported descriptively.
Results
All sites responded to the survey (3 hospitals have a common operating model hence supplied a single response). Most (11/18, 60%) rated their survivorship care as ‘developing’ and did not have a clear survivorship care policy (13/18, 72%). Provision of post-treatment information was inconsistent, as was assessment for needs. Most sites do not stratify survivors (< 25% of survivors received stratified care at 13/18 sites, 72%), provide survivorship care plans (< 25% survivors received SCP at 8/18 sites, 44%), and collect limited outcome data. Webinars were well received, with 98% of health professionals reporting improved knowledge and awareness. All seven sites valued targeted implementation support to improve aspects of survivorship care.
Conclusions
Current Victorian survivorship care appears suboptimal. There was good health professional engagement with educational webinars and with improvement activities.
Implications for Cancer Survivors
Results have informed survivorship improvement work, focusing on implementing policy, improving aspects of care delivery and building capability across the state.
The Role of Anesthesia in Decision-making for Robotic/Laparoscopic Urological Surgery: A Propensity Score Matching Analysis
Authors: Wei Mei-Yu , Zhang Ce , Hou Dong-Nan , Wen Li-Jie , Yang Bo
Published: November 2024

Background
Comparative studies between robotic and laparoscopic surgeries primarily focus on surgical aspects, with less emphasis on anesthesia. This study explores the role of the anesthesia team in making complex decisions between robotic-assisted laparoscopic surgery (RALS) and conventional laparoscopic surgery (CLS) by comparing postoperative indicators from Enhanced Recovery After Surgery (ERAS).
Methods: This retrospective analysis included patients who underwent partial nephrectomy and radical prostatectomy for prostate and renal cancer at the Urological Surgery Department of the Second Affiliated Hospital of Dalian Medical University from 2021 to 2023. Propensity score matching (PSM) with a 1:1 ratio was used, considering variables such as age, gender, BMI, operation type, and preoperative comorbidities. Primary outcomes included anesthesia, surgery, and recovery times. Secondary outcomes included resting and activity Visual Analog Scale (VAS) scores, voluntary activities, and the incidence of nausea/vomiting, dizziness, surgical site pain, respiratory depression, and anxiety on postoperative day one (POD1).
Results: A total of 252 cases were assigned to experienced RALS and CLS groups. The anesthesia and surgery times for RALS were 158.52 and 140.15 minutes, respectively, significantly longer than those for CLS (136.56 and 125.34 minutes) (P < 0.05). However, there were no differences in PACU recovery times (24.63 vs. 26.51 minutes) or rest-VAS scores (0.96 vs. 1.06) between the RALS and CLS groups. Activity-VAS scores showed a statistically significant difference between RALS (2.19) and CLS (1.86) (P < 0.05). The occurrence rates of voluntary activity, nausea/vomiting, dizziness, and anxiety were 19.5% vs. 29.1% (P < 0.01), 33% vs. 27.9% (P < 0.05), 25% vs. 18% (P < 0.05), and 12.6% vs. 16.8% (P < 0.05) for the RALS and CLS groups, respectively. No significant differences were observed in pharyngeal pain (6.3% vs. 10.1%), respiratory depression (0.5% vs. 1.7%), or oxygen requirement (5.2% vs. 7.8%) between groups.
Conclusions: From the anesthetist’s perspective, RALS extends surgery and anesthesia durations, increasing the potential risks to respiratory, circulatory, and central nervous systems during the perioperative period. RALS also increases the patient's financial burden. Therefore, it is crucial to consider the patient’s physical condition when selecting the surgical approach, alongside tumor prognosis and economic costs in clinical decision-making.
RETRACTED: Comparative study between a three and a five-level inverter for DTC control of the doubly fed induction motor
Authors: Cherifi Djamila , Miloud Yahia , ALI Omar OULED
Published: November 2024

The authors have requested that this preprint be removed from Research Square.
Identification and evaluation of tumor pyroptosis-associated antigens for design a vaccine candidate against lung cancer
Authors: Nguyen Truc Ly , Kim Heebal
Published: November 2024

Lung cancer is the leading cause of cancer-related mortality worldwide, necessitating the development of new treatment strategies. This study aims to design a novel multi-epitope vaccine targeting pyroptosis-associated proteins (CARD8, NAIP, NLRP1, and NLRP3) using immunoinformatics. T-cell and B-cell epitopes were identified from these proteins and assessed for antigenicity, non-toxicity, and immune-stimulatory potential. Fifteen epitopes with high scores were selected and combined with suitable adjuvants and linkers to form a vaccine construct. The three-dimensional structure of the vaccine was predicted, refined, and validated through molecular modeling techniques. Molecular dynamics simulations confirmed the vaccine's structural stability and flexibility under physiological conditions. Furthermore, in silico immune simulations suggested that the vaccine could elicit strong humoral and cellular immune responses, including high antibody production and robust T-helper and T-cytotoxic cell activation. These findings suggest the vaccine’s potential to generate long-term immunity. While computational predictions are promising, in vitro and in vivo validation is required to confirm the vaccine’s efficacy and safety. This study highlights the potential of targeting pyroptosis pathways in lung cancer and underscores the value of computational tools in accelerating vaccine design. If proven effective in experimental settings, this vaccine could contribute to more effective lung cancer immunotherapies, offering a new avenue for treatment in a disease with limited options.
A Novel Approach of Ransomware Detection with Dynamic Obfuscation Signature Analysis
Authors: Su Leli , Cheng Huapeng , Li Lianlian , Zhang Chicheng , Wang Yuanyuan , Zhao Jia
Published: November 2024

The exponential rise in ransomware attacks has intensified the demand for sophisticated detection methodologies capable of addressing complex evasion tactics. Dynamic Obfuscation Signature Analysis (DOSA) offers an adaptive, multi-layered framework designed to counter ransomware’s polymorphic transformations through a hybrid approach that combines static analysis, dynamic signature mapping, and machine learning-based adaptation. DOSA’s architecture enhances detection accuracy and operational efficiency, with a modular design that supports real-time processing across file-based, network-based, and memory-based detection layers. Experiments demonstrated that DOSA achieved high accuracy rates, maintaining detection efficacy across a diverse array of ransomware variants by continuously evolving signature profiles based on obfuscation patterns. The framework also exhibited substantial resource efficiency, making it suitable for deployment in diverse environments with varied computational constraints. By providing precise and adaptable threat detection, DOSA contributes a significant advancement to the field of ransomware resilience, offering a robust methodology for preemptive ransomware management within modern cybersecurity infrastructures.
Design and Evaluation of an Impact-Type Cacao Bean Huller
Authors: Hernando Herald Kam
Published: November 2024

The study mainly aimed to develop an impact-type cacao bean hulling machine and evaluate its performance in producing cacao nibs in terms of input capacity, hulling capacity, hulling efficiency, nib recovery, large nib recovery, purity, noise level, and power consumption. The cacao huller was subjected to three varying tangential velocities in the cracking mechanism, specifically at 40m/s, 47m/s, and 54m/s, and using three different volumes of air in the winnowing mechanism with 41m3/hr, 45m3/hr, and 49m3/hr. The data gathered were arranged in a Completely Randomized Design-Two Factorial and comparison among means using Statistical Tool for Agricultural Research (STAR) software. The analysis showed that the tangential speed of the machine significantly affected all parameters except purity and noise level; moreover, the air volume significantly affected the hulling efficiency, nib recovery, large nib recovery, and purity. Impact-type cacao bean huller with 47m/s and 41m3/hr gave the highest input and hulling capacities of 195.60kg/hr and 156.53kg/hr, respectively. Furthermore, the highest hulling efficiency, nib recovery, and large nib recovery of 96.84%, 96.98%, and 86.75%, respectively, were obtained from tangential velocity of 40m/s and volume of air of 41m3/hr. The lowest power consumption and noise level were obtained from the 40m/s and 45m3/hr combination with 3.99kwh and 88.20dB, respectively. Cost analysis showed that the machine was financially feasible with a payback period of 0.24 years and an annual net income of Php410,747.00. When considering mass production of cacao nibs, the most desirable setup of the machine was the combination of 40 m/s tangential velocity and 41 m3/hr volume of air.
Pengaruh Alam dan Budaya dalam Pembentukan Makanan Tradisional di Lembah Lenggong, Perak
Authors:   Fakulti Teknikal dan Vokasional, Universiti Pendidikan Sultan Idris, Perak, Malaysia, Abdul Raji Mohd Nazri ,   Institut Peradaban Melayu, Universiti Pendidikan Sultan Idris, Perak, Malaysia, Ab. Karim Shahrim ,   Fakulti Sains dan Teknologi Makanan, Universiti Putra Malaysia, Selangor, Malaysia, Esa Jamilah Hani ,   Jabatan Warisan Negara Zon Tengah, Lenggong, Perak, Malaysia
Published: November 2024

Traditional food is a valuable asset inherited from one generation to another. The formation of this traditional food in a specific district or country is influenced by various factors such as natural environment, cultural intermingling, political boundaries and local genius. As a result, the background and characteristic of traditional food can reflect the community’s origin, culture and identity. Despite that, research on the formation of traditional food is seemingly limited, particularly in rural areas. This phenomenon is due to the lack of appreciation of traditional food among the community especially the young generation. Thus, this study aims to understand the formation of traditional food in Lenggong Valley based on the influence of nature and culture. A qualitative research design was used in this study. The data was collected through semi-structured interviews, and purposive sampling technique was employed by the researchers. A total of 10 informants were involved in this study comprising Lenggong traditional food experts and entrepreneurs. In addition, snowball sampling technique was used to achieve data saturation. To validate the findings from semi-structured interviews, participant observations were also executed by the researchers. Several places were visited such as traditional food restaurants, events and homestays to conduct the observations. Findings for this study have concluded into two themes namely, (1) Lenggong traditional food based on the availability of natural resources; and (2) the influence of culture diversity in the formation of Lenggong traditional food. This study explores the formation process of Lenggong traditional food that is influenced by the natural environment and cultural diversity, in which the influence of both explains the ingenuity of the past people in crafting various types of food which can still be tasted until today. Findings for this study encourage the current generation to preserve and sustain this intangible heritage for the next generations to come. Beside inheritance, the uniqueness and differences of Lenggong’s traditional food connote a potential that can also be benefited as a tourist attraction.
Social Media As An Online Public Sphere: A Study among the First-Time Malay Voters
Authors:   Faculty of Leadership and Management, Universiti Sains Islam Malaysia, Negeri Sembilan, Malaysia, Kasmani Mohd Faizal
Published: November 2024

In a developing democracy like Malaysia, social media is pervasive in its influence on politics and democratic processes, particularly among the youth. Social media promotes the expression of opinions among groups, thereby opening up the realm of the public sphere in a semi-democratic country like Malaysia. Unlike the original conception of the public sphere, social media consists of spaces where citizens belonging to different groups and cultures, speak in different registers or languages, finding meaningful participation. Based on online interviews with 44 first-time voters among the Malay youth group, this article investigates the aspects of the interaction between young voters and the social media “public sphere.” It examines the platforms they use to communicate about politics, how they make sense of politics, and how they interact with other citizens through social media. The findings reveal four prevalent themes. First, young people have a keen interest in accessing political information on social media, albeit passively. Secondly, Twitter and Facebook were found to be the most influential social media channels for first-time voters seeking political information. Thirdly, out of concern about the surveillance practices on social media, private WhatsApp groups have emerged as the primary platform for first-time voters to engage in political discussions and debates. This leads us to the fourth theme, where the stories that feature on WhatsApp and Instagram are gaining prominence as the dominant platform for sharing political information. This trend highlights the potential for the incidental and ephemeral consumption of political content through these platforms. This trend may have significant implications for how political messages are communicated and received on these social media platforms.
Exploring Coping Strategies of Homeless Former Prisoners in Chow Kit Road, Kuala Lumpur
Authors:   School of Applied Psychology, Social Work and Policy, Universiti Utara Malaysia, Kedah, Malaysia, Jasni Mohd Alif ,   Institute for Psychotherapy, Correctional and Rehabilitation, Universiti Utara Malaysia, Kedah, Malaysia,   Ar-Riqab Welfare Organisation, Kuala Lumpur, Malaysia, Sulaiman Sabri ,   Faculty of Arts and Social Sciences, Universiti Malaya, Kuala Lumpur, Malaysia, Azmy Muna Maryam ,   School of Tourism, Hospitality and Event Management, Universiti Utara Malaysia, Kedah, Malaysia, Sohaimi Nor Suzylah ,   Research Institute for Indonesia, Thailand and Singapore, Ghazali Shafie Graduate School of Government, Universiti Utara Malaysia, Kedah, Malaysia
Published: November 2024

Subsisting on the streets requires homeless former prisoners to execute coping strategies, which were suggested in three major categories, namely, problemsolving-focused, emotion-focused, and avoidance. A lack of understanding exists regarding the coping strategies that homeless former prisoners utilise in navigating extremely challenging life conditions on the streets. Three strategies were selected and scrutinised in the current study to explore the key coping mechanism frequently employed by homeless former prisoners in tackling subsistence problems or challenges on the streets. A qualitative approach was administered by interviewing 30 homeless former prisoners to identify personal preferences for coping strategies. The findings revealed that the coping mechanisms were regularly employed simultaneously depending on the circumstances. Particularly, a higher tendency was demonstrated in applying avoidance coping operations, including drug abuse, solitude, pleasure-seeking activities, and worship, amongst homeless former prisoners. Nevertheless, homeless former prisoners also applied problem-solving focused coping strategies by searching for potential methods of higher income generation to improve their survival prospects. Summarily, formerly incarcerated individuals implemented coping strategies either collectively or interchangeably, subject to their current situations with varying suitabilities when subsisting on the streets. The implementation of these enhancements, along with greater integration of collective coping, will contribute to the advancement of significant intervention research. Research into coping strategies among homeless former prisoners can shed light on how these individuals adapt to life outside the prison system, how they develop survival skills, and how these skills may influence their behaviour and attitudes after release. Studying coping mechanisms post-release can offer insights into the challenges these individuals face when transitioning back into society
Political Breakthrough in a Rural Community during the 2011 Sarawak State Election: An Ethnographic Perspective
Authors:   Institute of Borneo Studies, Universiti Malaysia Sarawak, Sarawak, Malaysia, Bala Poline
Published: November 2024

This article draws on empirical data and ethnographic evidence as a springboard to explore issues affecting narratives and observations made during the 2011 Sarawak State Election. It throws light on ways in which communities and cultures at the periphery of the Malaysian nation state grapple with the potentials and consequences of elections in the process of economic, political and social transformation. Eschewing aspects of candidates’ selections, electoral campaign process and actual voting behaviour of individual voters, the main analysis is of the formulation of local understandings and meanings of the state elections in two rural settlements of Ba’ Kelalan and Bario located close to the border between Sarawak and Kalimantan. This article suggests that an account of their experiences is a necessity in order to understand what functions and whose interest elections serve, and most importantly what election actually does and means within particular circumstances of local history. As a political phenomenon, elections can look different from the perspective of those close to the centre of power in contrast to those with little power within a political hierarchy.
The Application of an Augmented Reality Offline System for Rural Tourism Development at Pa’ Lungan, Bario
Authors:   Faculty of Art, Sustainability and Creative Industry, Universiti Pendidikan Sultan Idris, Perak, Malaysia, Mohd Rafee Yakup , Maying Doris ,   Faculty of Applied and Creative Arts, Universiti Malaysia Sarawak, Sarawak, Malaysia, Aman Leong Sarah Naemah ,   Faculty of Applied and Creative Arts, Universiti Malaysia Sarawak, Sarawak, Malaysia
Published: November 2024

The development of rural tourism is one of the Malaysian government’s primary priorities for improving the socioeconomic and living conditions of the local community. Therefore, new ideas for assisting the rural population’s growth and economy through tourism must be explored. This article examines the application of augmented reality (AR) offline systems in improving this issue. It aims to review the planning, implementation, and effectiveness of the Interactive Digital Map (ID-MAP) as part of a rural tourism project in Pa’ Lungan, Bario, Sarawak. The study is carried out through a practical visual approach and analysed through observational, experiential and reflection approaches. The analysis elaborates on one of the main themes contained in the ID-MAP, which is linked to the famous tourist attraction of Pa’ Lungan – a megalithic rock called Batuh Ritung. The outcome was initially presented through an exhibition that applied digital information delivery using AR applications. As a result, an offline system was developed to assist locals in efficiently promoting tourism sites. This serves as an alternative platform that can verify the eligibility of tourist spots based on the existing digital and interactive multimedia systems, which are vital components in developing the smart village concept with Bario as a case study. Thus, this research has opened new interdisciplinary research opportunities and can be considered an alternative method to visual-based research, especially to stimulate the tourism industry and inform stakeholders and academics on the future of rural tourism.
RAPID QUANTITATIVE ANALYSIS OF METHAMPHETAMINE BY PORTABLE NEAR-INFRARED SPECTROSCOPY AND PLS MODELING
Authors: Liu Shan , Chen Yuemeng , Wang Fang , Wu Jingjie , Tang Guo , Bai Song
Published: November 2024

To rapidly detect different types of methamphetamine in the field, a portable near infrared spectroscopy (NIR) method was used to model and analyze the collected samples. Transmission spectra of 359 methamphetamine crystal samples (content range of 7.5-99.4%) and 187 methamphetamine tablet samples (content range of 2.43-23.91%) were collected, first-order derivatives and the Savitaki-Golay smoothing method were applied for spectral preprocessing. The drug concentrations in the calibration and validation sample sets were analyzed using high-performance liquid chromatography. The partial least squares quantitative analysis models were built, and the quantitative models for methamphetamine crystals were 2.10, 2.12 and 2.19% for root mean square error of cross-validation (RMSECV), root mean square error of validation (RMSEV) and root mean square error of prediction (RMSEP), respectively; in contrast, RMSECV, RMSEV, and RMSEP of methamphetamine tablets were 0.78, 0.80, and 0.82%, respectively. The results of the internal cross-validation and the methodology review show that the measurements of the modeled results are consistent with the true values, and that the model has good stability and can be used for accurate field measurements. Therefore, real time sample analysis can be performed using NIR technology combined with chemometric models, which helps the police to determine the quality of drugs in a timely manner for case analysis.
A Practical Guide to Verify which Analytical Techniques and Organic Foods have Already been Investigated
Authors: Valderrama Patrícia , S. Bruni Andressa Rafaella
Published: November 2024

Organic food is produced under specific regulations and must not contain residues from synthetic fertilizers, chemical pesticides, genetically modified organisms, hormones, and antibiotics. Several analytical methods were already been developed to evaluate different organic foods based on separation techniques or elemental analysis, as well as considering molecular spectroscopy. In some cases, chemometric tools were also considered. Research concerning organic food seems to have started in 1980. Until now, this has been a prominent topic of study. Thus, this review proposes a practical guide to verify which analytical techniques and organic food have already been investigated until this moment, which contributes to and facilitates the development of research in this latent topic of study.
The Role of Aspartate Aminotransferase / Platelet Ratio Index Score in Predicting Intrahepatic Cholestasis of Pregnancy and its Relationship with Total Bile Acid Level: A Case-Control Study from a Tertiary Center
Authors: Demir Merve , Sertel Emre
Published: November 2024

OBJECTIVES: The aim of this study is to examine the value of the first-trimester aspartate aminotransferase to platelet ratio index (APRI) score in predicting intrahepatic cholestasis of pregnancy (ICP) occurring later in pregnancy. Another aim of the study is to determine the relationship between APRI scores and total bile acid (TBA) levels in pregnant women with ICP.
STUDY DESIGN: This retrospective case-control study was conducted by examining the hospital records of women diagnosed with ICP (n=66) and healthy controls (n=70) among women followed during pregnancy. Hemoglobin (Hb), platelet count (PLT), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) values of all patients were obtained from routine blood test data taken in the first and third trimesters. The first and third-trimester APRI scores of the patients were calculated. Demographic data, laboratory findings, and APRI scores of women with and without ICP during pregnancy were compared. Using Roc analysis, the values of AST, ALT, PLT values, and APRI scores were examined in predicting ICP among the first trimester findings of the patients. In addition, TBA levels of patients with ICP at the time of diagnosis were obtained from hospital records. The relationship between the first and third-trimester APRI scores and TBA levels in patients with ICP was evaluated using correlation analysis.
RESULTS: In the first and third-trimester laboratory values, AST and ALT levels and APRI scores were found to be higher and PLT values were lower in patients with ICP compared to healthy controls. Among the first trimester measurements of these data, the APRI score had the highest predictive value in predicting ICP (AUC values are 0.648 for AST, 0.655 for ALT, 0.633 for PLT, and 0.705 for APRI). In an examination of patients with ICP, the APRI score calculated in the first and third trimesters showed a positive correlation with the TBA level at diagnosis (r=0.435 p<0.001 for the first trimester and r=0.433 p<0.001 for the third trimester in the Spearman analysis).
CONCLUSIONS: In the future, the APRI score calculated in the first trimester of pregnancy may be used as a tool to predict ICP that may occur in the following weeks. There may be a positive correlation between APRI score and serum TBA level in patients with ICP.
Relationship of strength and difficulty factors and video game addiction in adolescents of Denpasar Junior High School
Authors: Kurniawan I Gde Yudhi , Mahardika I Komang Ana , Aryani Luh Nyoman Alit , Santosa I Ketut Arya
Published: November 2024

Introduction: Video game addiction in adolescents can result in negative impacts on daily functioning, including personal, social, and educational. Finding the strength and difficulty factors and the related factors is beneficial for better diagnosis and treatment. Method: This study was conducted using a cross-sectional study design to examine the relationship between strength and difficulty factors and video game addiction. The research was conducted at three chosen junior high schools in Denpasar City from March to April 2024. The inclusion criteria are junior high school students in Denpasar City. The exclusion criteria were students with severe comorbidities, a history of psychiatric disorders, and who refused research approval. Data analysis consists of descriptive statistical analysis, proportional comparison analysis, and logistic regression tests. Result: From the 209 samples, 56.9% were male, 36.4% played long games, 71.3% had WIFI at home, and 64.6% had low-income parents. The distribution of supporting and confounding factors in the sample based on the Strength and Difficulty Questionnaire (SDQ) found that the prevalence of abnormal emotions was 82 (39.2%), abnormal Conduct was 67 (32.1%), abnormal hyperactivity was 105 (50.2%), abnormal peer was 139 (66.5%), total difficulty (ECHP) was 131 (62.7%) and abnormal prosocial was 23 (11%).
O léxico nos anúncios de emprego: um estudo em países lusófonos
Authors: Ribeiro Sílvia
Published: November 2024

This article aims to contribute to the description of the lexicon used in job advertisements, specifically by analysing the profession/occupation nouns that appear as titles in 300 job advertisements published online in three Portuguese-speaking countries: Angola, Brazil and Portugal. The study involved identifying and describing the main word formation processes that operate in the construction of these nouns, proposing a comparative analysis of the data from the three countries in scope. The results obtained confirm trends found in other Romance languages (Marchal & Torny 2003; Buvet 2018), with a prevalence of compositional profession/occupation nouns, mainly following the Noun-Preposition-Noun compositional scheme, which may be related to the growing technicality and specialisation of these nouns. The use of English terms is also relevant, especially in adverts published in Portugal, which reflects a trend already studied in other countries (van Hooft 2015; Andreani & Pulcini 2016)
Comprehensive Analysis of Allerkhand Tablet: A Novel Ayurvedic Herbal Formulation helps to regulates the Allergic Conditions
Authors: Bijeshmon PP  , Sibi Narayanan  , Anusree NM  , Meera Mohan K  , Greeshma KM  , Veena K  , Jewel Varghese
Published: November 2024

The increasing interest in alternative and complementary therapies has spotlighted Ayurveda, an ancient system of medicine, for its holistic approach in managing allergies. Ayurvedic treatments for allergy typically focus on restoring balance of the Vitiated Doshas. This may involve dietary corrections, lifestyle changes, and the use of herbal remedies and rejuvenation therapies. Curcumin, the active component of turmeric, has been extensively studied for its anti-inflammatory, antioxidant, and immunomodulatory properties, which can be beneficial in managing allergic conditions. The current study was conducted for a scientific evaluation of Allerkhand tablet, an Ayurvedic patent medicine used to treat allergy and boost immunity. Allerkhand, a poly-herbal tablet formulation with Curcuma longa as the main ingredient and 18 other constituents, serves to improve immunity by combining anti-allergic and anti-histaminic effects. The product was subjected to qualitative phytochemical HPTLC, HPLC, and anti-microbial studies. Phytochemical analysis of Allerkhand in aqueous and methanolic extracts revealed the presence of 13 and 8 common compounds, respectively. According to HPTLC and HPLC analysis, sufficient quantity of curcuminoids are present in tablets. Significant antimicrobial zones were found against six bacterial strains. These findings support the traditional use of Allerkhand tablets as a natural remedy in regulating allergic conditions.
An Ayurvedic approach in the management of Vataj and Pittaj Jiwakantaka with special reference to Glossitis
Authors: Rounak Munshi  , Deepak Pandey
Published: November 2024

The article provides information about the management of Vataj and Pittaj Jiwakantaka with special reference to Glossitis, deals with the management of glossitis compared to Vataj and Pitaj Jiwakantaka which is the disease of Ayurveda, article consists of the definition, diagnoses and the management of glossitis, also the Ayurvedic approach and the management of the Jiwakantaka and the drugs related to its treatment as mentioned in Ayurveda.
A summarize review of few plants: Its Anti-Inflammatory properties due to their Phytochemical Components
Authors: Polly Gupta  , Shashank Tiwari
Published: November 2024

The aim of this review paper was to summarize some commonly available plants which have anti-inflammatory activity with their phytochemical constituents. The data were collected from Current Contents and Scientific Journals, which included in publications. In this paper, the plants have anti-inflammatory activity along with their phytochemical constituents and also mention the family, part used of the every plants. Herbal plants play a significant role in human health in relation to the prevention and treatment of inflammatory conditions. Herbal medicines are popular among the public and improvements in their formulation have resulted in a new generation of phytomedicines that are more potent than before. This paper highlights on the phytochemical constituents of anti-inflammatory activity of some herbal medicines used for treating inflammatory disorders and recent developments in various herbal species. The review gives a comprehensive overview of the phytochemical constituents of medicinal plants with anti-inflammatory potential.
Understanding the influence of Manasika Bhavas on Stanya Kshaya: A Conceptual Study
Authors: Hima Mol V.  , Prathima
Published: November 2024

Breast milk stands as the foremost source of nutrition in every individual's early life. According to Ayurveda, Stanya is considered an Upadhatu of Rasa and is pivotal for the nourishment and development of infants. Ayurveda defines decreased breast milk or lactation insufficiency as Stanya Kshaya, primarily attributed to emotions like anger, grief, and excessive affection, alongside dietary influences. Psychological factors such as emotional stress, anxiety, and maternal health also significantly impact milk production, necessitating both psychological and medical interventions. Any disruption in Agni affects Ahara Rasa, leading to disturbances in Rasa Dhatu, thereby affecting Stanya. Psychological aspects play a crucial role in the proper formation of Ahara Rasa. The significance of Manasika Bhavas lies in their advocacy of Soumanasya as a primary treatment for Ksheerajanana. This paper explores the correlation between psychological well-being and lactation outcomes, drawing on both contemporary psychological research and traditional Ayurvedic principles. Psychological stress, anxiety, depression, and maternal bonding are examined as key factors affecting hormonal balance and neuroendocrine pathways involved in lactation. Understanding these influences is crucial for holistic approaches to maternal health and breastfeeding support. The integration of psychological interventions alongside conventional medical treatments could enhance maternal lactation success rates and overall maternal-infant health outcomes. Thus, managing Stanya Kshaya requires thorough consideration of both psychological factors and dietary practices.
A critical review on usage of Ghrita in Pandu
Authors: Shivani V. Shete  , Parshuram D. Dongare  , V. S. Boinwad
Published: November 2024

According to Ayurveda, human body is made up from Saptdhatu, Tridosha and Trimal. These are the main functional unit which maintains equilibrium in body. Agni plays most important role in metabolism of body. With the help of Agni, food is converted into absorbable form and also it forms and nourishes Saptdhatu in progressive manner continuously. Any type of disequilibrium in the process, gives rise to diseases like Pandu, Grahani, Kushtha etc. Pandu Roga is disease entity described in Ayurvedic literature which is characterized as pallor complexion of the skin of the diseased person. Pandu is widely described in various Ayurvedic texts as an independent disease and also as associated symptom in many other diseases. The general treatment of Pandu is Snehana, Shodhana, Shamana with herbo-mineral combinations along with dietary modifications. There is specific mention of internal oleation before Shodhana Chikitsa is advised which marks its importance in treatment. Ghritpan is considered best for ignition of Jatharagni as well as Dhatvagni and it also has properties like Jivaniya, Rasayana etc. Ghritapan opposes the etiology of Pandu at level of constitution and diet. In Pandu Chikitsa Adhyay, various medicated Ghrita are described. This present study critically reviews role of Ghritapan in Pandu and different combination of medicated Ghrita described in Pandu Chikitsa Adhyay by Acharya Charaka along with its specific indications.
Efficacy of Ayurveda in the Prevention of Lifestyle Diseases or Non-Communicable Diseases (NCDs)
Authors: Sneha Srivastava  , Ritu K. Sureka
Published: November 2024

Lifestyle diseases occur due to an individual's everyday regimen and arise from an incorrect interaction between individuals and their environment. Bad eating habits, physical inactivity and a disrupted biological clock are primarily responsible for such diseases. In this context Ayurveda offers a well-organized system of conventional health care that promotes health maintenance and disease prevention via adherence to a balanced diet and vigorous lifestyle. There has been a strong connection between Ayurveda and Nutrition since ancient times. Interest in Ayurveda has grown across the globe due to its potential for managing and preventing lifestyle disorders. Acknowledged as one of the leading life sciences Ayurveda offers effective solution through Panchakarma, Rasayana, dietary control, lifestyle advice and rejuvenating therapies. The most effective and significant method in use is Ashtanga Yoga, a combination of Yogic and meditation exercises beneficial for regulating one's senses, focus and combating lifestyle disorders. Thus, Ayurveda is a holistic approach to health designed to help people live long, healthy and balanced life free from illness and diseases. This paper examines the causative factor behind certain lifestyle diseases and lays stress on their prevention through Ayurvedic techniques.
Evaluation of Antifungal Activity of Somaraji Taila Extract & Taila in Dadru Kushta (Tinea Infections) - An Experimental Study
Authors: Prashanth Gadgade  , Susheel Shetty  , Babu Paul
Published: November 2024

Dermatophytosis has become a significant health problem affecting children, adolescents, and adults worldwide. In India 5 out of 1000 people suffer from Tinea infections. The present study evaluated the antifungal activity of Somaraji Taila in Tinea (Dermatophytosis) in Invitro & Invivo model. Cultures were brought from MTCC a government body and inoculated in SDA media under aseptic condition. Later it was subjected to microscopic and macroscopic examination to identify the organism. A sensitivity test was done using SDA media by well diffusion method, with 4 different concentrations of Hydro-Methanolic extraction of Somaraji Taila ingredients. After the incubation period, the zone of inhibition was checked and was measured in mm. As the next phase of the study, animal study was also conducted to check antifungal properties & anti dermal toxicity on albino rat skin.
Review on understanding of Astha Sthoulya Doshas and Sthoulya Lakshanas
Authors: Vardhaman Iraj  , Mahesh Hirulal
Published: November 2024

Sthoulya is one among Santarpanotta Vikara and it is caused by Kapha Pradhana and Medodhushti. All the Santarponotta Nidanas and Medodhushti which will lead for Sthoulya. Sthoulya mainly features Chala Sphik Sthanah Udara Lambanam and Atisweda, Dhourgandy, Dourbalya as associated symptoms and these are considered as Sthoulya Doshas. Sthoulya leads to Kshudra Swasa and Alpaprana. Which implies the effect of Sthoulya on Pranavaha Srotas i.e., impairment in respiratory function which indicates Sthoulya does changes in normal breathing pattern. Life style disease and non-communicable diseases are major concern of health in present era. Obesity and Overweight are the major health care challenge that occupies the first place among non-communicable diseases creating an enormous socioeconomic and public health burden in most countries and is a worldwide epidemic. The worldwide prevalence of obesity nearly tripled between 1975 and 2020. Involvement of Meda, Agni, Kapha and Vata make the vicious curve of Samprapthi leading to chronic symptoms and complications like Ashta Sthoulya Doshas. Involved Agni and Ama in different stages which will make complicity to manage the Stholya and holistic approach is needed to treat the comorbidities like Ashta Sthoulya Doshas.
Role of Dashanga Lepa in Prameha Pidika
Authors: Ashima Kahi
Published: November 2024

Diabetes is a sickness recognized for its multifaceted headaches. Diabetic ulcer is one of the primary complications of diabetes. Diabetes impacts more than 8% of Indian person population. Up to 25% of diabetic sufferers develop foot ulcers. greater than 1/2 of foot ulcers come to be inflamed and require hospitalization and 20% of infections outcomes in amputation. Early powerful control can reduce the severity of complications along with preventable amputations and viable mortality and can also enhance universal pleasant of lifestyles. thousands of researches are being executed in this in which Ayurveda has a main role. distinctive numbers of Prameha Pidakas are cited in Ayurvedic Classics, according to Acharya Sushruta there are 10 distinctive styles of Prameha Pidakas. Dashanga Lepa is a poly herbal practice of Ayurveda, used to treat many skin ailments and Prameha Pidaka. In this article details description regarding Prameha Pidaka and Dashanga Lepa is explained.