bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical value of combined predictors of RET%, γ-GT, LDH in the ABO neonatal hemolytic disease
Authors: Liu Xiaoxiao , Dong Yan , Qin Yingchao , Xue Chunyan , Lyu Wei
Published: December 2023

Objective

The purpose of this study is to examine the prognostic significance of the amalgamated indicators, reticulocyte percentage (RET%), lactate dehydrogenase (LDH), and γ-Glutamyltransferase (γ-GT), in neonatal ABO hemolytic disease.

Methods

A total of 137 hospitalized children with pathological jaundice were included. Based on their medical conditions, they were categorized into two groups, hemolytic (67 cases) and non-hemolytic (70 cases). Pearson linear correlation and binary logistic multivariate analysis were used to analyze LDH, γ-GT, RET% and hemolysis. Furthermore, the predictive value of the combined predictors of RET%, LDH, and γ-GT on ABO neonatal hemolytic disease was evaluated using the ROC curve analysis.

Results

The laboratory indexes of the two groups were subject to analysis using binary logistic regression to identify suspicious influencing factors. The study revealed that RET%, LDH, and γ-GT were independent risk factors for hemolysis. Pearson linear correlation analysis indicated a positive correlation between LDH and γ-GT with RET% (r = 0.529, P < 0.01; r = 0.526, P = <0.01, respectively). Furthermore, the predictive value of each combined predictor was obtained using the ROC curve, and it was observed that combined predictor L (RET% + LDH + γ-GT)>L1 (RET% + LDH)>L2 (RET% + γ-GT).

Conclusion

Combined predictor L (RET% + LDH + γ-GT)demonstrate its optimal diagnostic efficacy, offering a novel approach towards diagnosing early-onset ABO hemolytic disease of the newborn.
Repurposing of Bryophyllum pinnatum for dysmenorrhea treatment: a systematic scoping review and case series
Authors: Zurfluh Leonie , Spinelli Marialuigia Giovannini , Betschart Cornelia , Simões-Wüst Ana Paula
Published: December 2023

Dysmenorrhea affects women throughout their reproductive years but there has been a lack of effective and well-tolerated treatment options. Pain symptoms mainly result from inflammatory processes and increased contractile activity in the myometrium. The reported use of Bryophyllum pinnatum preparations against inflammation and pain in ethnomedicine as well as current pharmacological data on their inhibition of myometrial contractility led us to hypothesize that this medicinal plant might be a new treatment option for dysmenorrhea. In the first part of the present work, clinical, in vivo, and in vitro studies on the anti-nociceptive and anti-inflammatory, as well as on myometrium relaxing properties of B. pinnatum are reviewed. In the second part, cases of five women with dysmenorrhea who were tentatively treated with a B. pinnatum product are described. The review revealed thirty-three experimental in vivo and in vitro studies, but no clinical study, reporting anti-nociceptive and anti-inflammatory effects of B. pinnatum extracts and compounds in a wide range of conditions. Moreover, sixteen publications on smooth muscle contractility revealed relaxing effects. The latter consisted of clinical evidence, as well as of in vivo and in vitro data. The evidence reviewed therefore provided a rational basis for the use of B. pinnatum in the treatment of dysmenorrhea. We subsequently set out to tentatively treat patients with a well-tolerated B. pinnatum product that is registered (without indication) and commonly used in obstetrics and gynecology in Switzerland. All five treated patients reported a reduction in pain symptoms and 4 out of 5 indicated a reduced intake of painkillers during menstruation. Taken together, the reviewed information on the pharmacological properties and clinical evidence of B. pinnatum extracts and compounds as well as the outcomes of all five patients in the case series support our hypothesis in favor of B. pinnatum as a new, well-tolerated therapeutic approach for dysmenorrhea. Prospective clinical studies are urgently needed.
Identifying hotspots of woody plant diversity and their relevance with home ranges of the critically endangered gibbon (Nomascus hainanus) across forest landscapes within a tropical nature reserve
Authors: Li Xinran , Zhang Zhidong , Long Wenxing , Zang Runguo
Published: December 2023

Introduction

To achieve effective conservation objectives, it is crucial to map biodiversity patterns and hotspots while considering multiple influencing factors. However, focusing solely on biodiversity hotspots is inadequate for species conservation on a landscape scale. This emphasizes the importance of integrating hotspots with the home ranges of species to identify priority conservation areas.

Methods

Compiling the vegetation data with environmental and anthropogenic disturbance data collected from kilometer-grid plots in Bawangling Nature Reserve, Hainan, China, we analyzed the spatial distribution of plant diversity (species richness and Shannon-Wiener index), as well as the main drivers affecting these patterns. We also investigated the spatial distribution of hotspots using a threshold approach and compared them with the home ranges of the flagship species, Hainan gibbon (Nomascus hainanus).

Result

Climate and soil are predominant drivers shaping the spatial pattern of plant diversity in Bawangling Nature Reserve, surpassing the influence of anthropogenic disturbance and topographic factors. Both diversity indices exhibit a generally similar pattern with exceptions in surrounding areas of Futouling and Elongling. The hotspots identified by the Shannon-Wiener index showed a higher spatial overlap with the home ranges of Hainan gibbon compared to the species richness hotspots. The recently established Hainan gibbon Group E in 2019, located 8 km away from the original Futouling habitat, does not coincide with identified hotspots.

Discussion

Our findings indicate that the hotspots of plant diversity within the habitat of Hainan gibbon Group E are relatively limited, emphasizing the necessity of giving precedence to its conservation. Integrating hotspots with the home ranges of critically endangered species offers decision-makers valuable information to establish rational conservation networks in the context of changing environments, as well as a reference for habitat restoration of species.
The impact of a speaker’s voice quality on auditory perception and cognition: a behavioral and subjective approach
Authors: Schiller Isabel S. , Aspöck Lukas , Schlittmeier Sabine J.
Published: December 2023

Introduction

Our voice is key for conveying information and knowledge to others during verbal communication. However, those who heavily depend on their voice, such as teachers and university professors, often develop voice problems, signaled by hoarseness. The aim of this study was to investigate the effect of hoarseness on listeners’ memory for auditory-verbal information, listening effort, and listening impression.

Methods

Forty-eight normally hearing adults performed two memory tasks that were auditorily presented in varied voice quality (typical vs. hoarse). The tasks were Heard Text Recall, as part of a dual-task paradigm, and auditory Verbal Serial Recall (aVSR). Participants also completed a listening impression questionnaire for both voice qualities. Behavioral measures of memory for auditory-verbal information and listening effort were performance and response time. Subjective measures of listening effort and other aspects of listening impression were questionnaire rating scores.

Results

Results showed that, except for the aVSR, behavioral outcomes did not vary with the speaker’s voice quality. Regarding the aVSR, we found a significant interaction between voice quality and trial, indicating that participants’ recall performance dropped in the beginning of the task in the hoarse-voice condition but not in the typical-voice condition, and then increased again toward the end. Results from the listening impression questionnaire showed that listening to the hoarse voice resulted in significantly increased perceived listening effort, greater annoyance and poorer self-reported performance.

Discussion

These findings suggest that hoarseness can, at least subjectively, compromise effective listening. Vocal health may be particularly important in the educational context, where listening and learning are closely linked.
Body image disturbance, interoceptive sensibility and the body schema across female adulthood: a pre-registered study
Authors: Naraindas Akansha M. , Cooney Sarah M.
Published: December 2023

Introduction

Body image disturbance (BID) typically involves explicit negative attitudes toward one’s shape and weight and is associated with altered interoceptive sensibility (the subjective perception of internal bodily states). This association is a known risk factor for the development and maintenance of eating disorders. However, while research has centred on younger women with eating disorders, diverse facets of BID appear in women without eating disorders across adulthood. Research shows that in the general population, young women (ages 18–25) with high BID exhibit disturbances in the body schema: an implicit sensorimotor representation of the body in space which includes mental simulation of a movement such as motor imagery. Given that body image is subject to age-related influences, it is important to investigate how age-related variation in BID can influence the body schema beyond young adulthood alone. Here, we examine the relationship between BID, interoceptive sensibility and the body schema across female adulthood.

Methods

Cross-sectional data was collected online from 1,214 women across four age groups: Young adults (18–24), Adults (25–39), Middle-aged adults (40–59), and Older aged adults (60–75). BID was indexed by questionnaires measuring body objectification, state, and trait body dissatisfaction. Interoceptive sensibility (IS) was measured using the MAIA-2 questionnaire. The body schema was evaluated through the Own Body Transformation task: a mental rotation task which assesses the capacity to make an embodied mental transformation.

Results

Analyses revealed that while body objectification and trait body dissatisfaction decreased from young to older adulthood, state body dissatisfaction showed a marked increase. A negative relationship between IS and BID across all age groups was also evidenced. Finally, age, BID and orientation of the presented body were significant predictors of the time taken to make an embodied transformation.

Discussion

These findings highlight the consistent relationship of BID and IS across age groups beyond young adulthood and demonstrate the varying importance of different aspects of BID as individuals age. We also evidence for the first time that disruptions in body image have the potential to impact implicit sensorimotor representations of the body even in women without eating disorders across female adulthood.
Validity of an online, self-administered Timeline Followback for alcohol use with adolescents
Authors: Hareskov Jensen Natascha , Vallentin-Holbech Lotte , Dash Genevieve F. , Feldstein Ewing Sarah W. , Rømer Thomsen Kristine
Published: December 2023

Objective

The Timeline Followback (TLFB) is a widely used and well-validated interview-based tool for assessing patterns of recent health risk behavior. There is some evidence of the validity of the TLFB as a self-administered online tool for assessing alcohol use, but further research is needed to establish its validity in younger populations and populations outside the United States. Further, it is unknown how self-administered online TLFB formats compare to more timesaving and commonly used single-item alcohol questions. The primary aim of the current study was to validate a new online, self-administered TLFB for alcohol use against the TLFB interview in a sample of European (Danish) adolescents aged 16–18 years (N = 30).

Methods

Participants completed a TLFB telephone interview, a self-administered online version of the TLFB, and single-item alcohol questions. Assessments were administered using a within-subject, counter-balanced design. Estimates of number of drinking days, binge-drinking days, maximum drinks consumed on one occasion, total drinks, and drinks per drinking day were compared across metrics.

Results

All correlations between the drinking outcomes assessed via the TLFB interview and the TLFB online were positive, and statistically significant (rss = 0.86–0.94, p < 0.01). Wilcoxon signed-rank tests showed no significant differences between the TLFB interview and the TLFB online on drinking days, binge drinking days, max drinks, and total drinks. Participants reported drinking significantly more drinks per drinking day on the TLFB online (M = 4.66) compared to on the TLFB interview (M = 4.12; p = 0.009).

Conclusion

Overall, the results support the validity of the online, self-administered TLFB in a sample of European (Danish) adolescents.
Evolving trends among Pseudomonas aeruginosa: a 12-year retrospective study from the United Arab Emirates
Authors: Thomsen Jens , Menezes Godfred A. , Abdulrazzaq Najiba M. ,   The UAE AMR Surveillance Consortium, Moubareck Carole Ayoub , Senok Abiola , Everett Dean B.
Published: December 2023

Introduction

Pseudomonas is a group of ubiquitous non-fermenting Gram-negative bacteria (NFGNB). Of the several species associated with humans, Pseudomonas aeruginosa (PA) can acclimate to diverse environments. The global frequency of PA infections is rising and is complicated by this organism's high intrinsic and acquired resistance to several clinically relevant antibiotics. Data on the epidemiology, levels, and trends of antimicrobial resistance of PA in clinical settings in the MENA/GCC region is scarce.

Methods

A retrospective 12-year analysis of 56,618 non-duplicate diagnostic Pseudomonas spp. from the United Arab Emirates (UAE) was conducted. Data was generated at 317 surveillance sites by routine patient care during 2010–2021, collected by trained personnel and reported by participating surveillance sites to the UAE National antimicrobial resistance (AMR) Surveillance program. Data analysis was conducted with WHONET (https://whonet.org/).

Results

Among the total isolates (N = 56,618), the majority were PA (95.6%). Data on nationality revealed 44.1% were UAE nationals. Most isolates were from soft tissue (55.7%), followed by respiratory tract (26.7%). PA was more commonly found among inpatients than among outpatients, followed by ICUs. PA showed a horizontal trend for resistance to fluoroquinolones, 3rd- and 4th-generation cephalosporins, and decreasing trends of resistance for aminoglycosides and meropenem. The highest percentage of multidrug resistant (MDR) isolates was reported in 2011 at 35.6%. As an overall trend, the percentage of MDR, extensively drug-resistant (XDR), and possible pandrug-resistant (PDR) isolates generally declined over the study period. Carbapenem-resistant PA (CRPA) were associated with a higher mortality (RR: 2.7), increased admission to ICU (RR: 2.3), and increased length of stay (LOS) (12 excess inpatient days per case), as compared to carbapenem-susceptible PA (CSPA).

Conclusion

The resistance trends in Pseudomonas species in the UAE indicated a decline in AMR and in percentages of Pseudomonas isolates with MDR and XDR profiles. The sustained Pseudomonas spp. circulation particularly in the hospital settings highlights the importance of surveillance techniques, infection control strategies, and stewardship to limit the continued dissemination. This data also shows that CRPA are associated with higher mortality, increased ICU admission rates, and a longer hospitalization, thus higher costs due to increased number of in-hospital and ICU days.
The impact of centralized coronary stent procurement program on acute myocardial infarction treatments: evidence from China
Authors: Jian Weiyan , Zhou Wuping , Zhang Lanyue
Published: December 2023

Background

The advent of coronary stents has resulted in many more many lives being saved from acute myocardial infarction (AMI). However, the high price associated with this method of treatment also imposes a heavy economic burden on healthcare systems. As a country making significant use of coronary stents, in 2021, China introduced a program around this method of treatment grounded in centralized procurement and it is the focus of this paper to assess the impact of this policy on AMI treatments.

Methods

The patients with AMI are selected as the study group, and the patients with pre-cerebral vascular stenosis are selected as the control group, and individual-level medical insurance settlement data are collected from the years 2018, 2019, and 2021. Differences-in-differences methodology is used to analyze the impacts of this program on the probability changes in respect of AMI patients receiving stent therapy, as well as changes relating to cost, length of stay and 30-day readmission.

Results

The results show that the reform has led to a reduction in the probability of AMI patients using stents to 51% of the original rate. Additionally, the average cost is shown to have decreased by 41%, and no significant changes can be found in respect of the length of stay and 30-day readmission.

Conclusion

In sum, the centralized procurement program is shown to reduce not only the medical expenses incurred by treating patients with AMI, but also the use of coronary stents, resulting in changes to the treatment patterns of patients with AMI.
Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: an experience of a multidisciplinary rehabilitation program at a physical and rehabilitation medicine unit
Authors: Paéz Valeria , Rodriguez-Fernandez Maria , Morales Diego , Torres Camillo , Ardiles Andrés , Soza Sergio , Bustos Cynthia , Manríquez Fernanda , García Cesar , Rocco Rossana , Lang Morin
Published: December 2023

Background

Post-COVID disabilities, encompassing physical, cognitive, and psychological aspects, constitute the primary health sequelae for survivors. While the rehabilitation needs post COVID-19 are now well understood, each country possesses unique characteristics in terms of populations, healthcare systems, social dynamics, and economic profiles, necessitating context-specific recommendations. This study aims to address two main objectives: (1) analyze the impact of an 8-week multidisciplinary rehabilitation program on the quality of life, functional capacity, cognition, and mental health adaptations in adults recovering from COVID-19 in northern Chile, and (2) propose a personalized model for predicting program dropouts and responses.

Methods

A total of 44 subjects were enrolled, forming two groups during the study: a treatment group (n = 32) and a dropout group (n = 12). The treatment group participated in the 8-week multidisciplinary rehabilitation program.

Results

The results indicate that (1) After 8 weeks, the quality of life of the patients in the treatment group exhibited significant improvements reflected in all aspects of the Short Form-36 Health Survey (SF36, p < 0.005) and the total score (p < 0.001), with a concurrent decrease in dysfunctionality (p < 0.001). (2) Significant improvements were also observed in various physical performance tests, including the: 6-minute walk test, 1-min sit-to-stand, dynamometry, Tinetti balance, and Berg score (p < 0.001). Moreover, physical therapy led to a reduction in neuropathic symptoms and pain, psychological therapy reduced anxiety and depression, and language therapy enhanced memory and speech (all p < 0.05). (3) Demographic and clinical history characteristics did not predict responses to rehabilitation. (4) A regression model for predicting changes in SF-36 total score, based on physical function, physical role, general health, and mental health, was established based on the data from study (p < 0.01, adjusted R2 = 0.893). (5) Classification models for predicting dropouts achieved 68% accuracy, with key predictors of treatment adherence including diabetes, hypertension, and dyslipidemia, Tinetti balance, physical role, and vitality of SF36, and performance on the 6-minute walk test and 1-minute sit-to-stand.

Conclusions

This study demonstrates significant enhancements in quality of life, improved functional performance, and reductions in mental and cognitive burdens within an 8-week rehabilitation program. Additionally, it is possible to identify patients at risk of dropping out using cost-effective, outpatient, and clinically applicable tests.
Diffusiophoresis: a novel transport mechanism - fundamentals, applications, and future opportunities
Authors: Ganguly Arkava , Alessio Benjamin M. , Gupta Ankur
Published: December 2023

Diffusiophoresis involves the movement of colloidal-scale entities in response to concentration gradients of a solute. It is broadly categorized into two types: passive and active diffusiophoresis. In passive diffusiophoresis, external concentration gradients drive the motion, while in active diffusiophoresis, the colloidal entity itself assists in generating the gradients. In this perspective, we delve into the fundamental processes underlying passive and active diffusiophoresis and emphasize how prevalent both kinds of diffusiophoresis are in colloidal and natural systems. In particular, we highlight the colloidal focusing feature in passive diffusiophoresis and discuss how it underpins the variety of experimental observations and applications such as low-cost zetasizers, water filtration, and biological pattern formation. For active diffusiophoresis, we emphasize the dependence of particle trajectory on its shape and surface heterogeneity, and discuss how this dictates the applications such as drug delivery, removal of microplastics, and self-repairing materials. Finally, we offer insights and ideas regarding future opportunities in diffusiophoresis.
Risk perceptions of individuals living in single-parent households during the COVID-19 crisis: examining the mediating and moderating role of income
Authors: Liedl Bernd , Fritsch Nina-Sophie , Samper Mejia Cristina , Verwiebe Roland
Published: December 2023

The COVID-19 crisis had severe social and economic impact on the life of most citizens around the globe. Individuals living in single-parent households were particularly at risk, revealing detrimental labour market outcomes and assessments of future perspectives marked by worries. As it has not been investigated yet, in this paper we study, how their perception about the future and their outlook on how the pandemic will affect them is related to their objective economic resources. Against this background, we examine the subjective risk perception of worsening living standards of individuals living in single-parent households compared to other household types, their objective economic situation based on the logarithmised equivalised disposable household incomes and analyse the relationship between those indicators. Using the German SOEP, including the SOEP-CoV survey from 2020, our findings based on regression modelling reveal that individuals living in single-parent households have been worse off during the pandemic, facing high economic insecurity. Path and interaction models support our assumption that the association between those indicators may not be that straightforward, as there are underlying mechanisms–such as mediation and moderation–of income affecting its direction and strength. With respect to our central hypotheses, our empirical findings point toward (1) a mediation effect, by demonstrating that the subjective risk perception of single-parent households can be partly explained by economic conditions. (2) The moderating effect suggests that the concrete position at the income distribution of households matters as well. While at the lower end of the income distribution, single-parent households reveal particularly worse risk perceptions during the pandemic, at the high end of the income spectrum, risk perceptions are similar for all household types. Thus, individuals living in single-parent households do not perceive higher risks of worsening living standards due to their household situation per se, but rather because they are worse off in terms of their economic situation compared to individuals living in other household types.
Prognostic factors of poor postoperative outcomes in gastrectomies
Authors: Stüben B. O. , Plitzko G. A. , Stern L. , Li J. , Neuhaus J. P. , Treckmann J. W. , Schmeding R. , Saner F. H. , Hoyer D. P.
Published: December 2023

Background

Gastric cancer is one of the most common cancers worldwide and is the third most common cause of cancer related death. Improving postoperative results by understanding risk factors which impact outcomes is important. The current study aimed to compare immediate perioperative outcomes following gastrectomy.

Methods

302 patients following gastric resections over a 10-year period (January 2009–January 2020) were identified in a database and retrospectively analysed. Epidemiological as well as perioperative data was analysed, and a univariate and multivariate analysis performed to identify risk factors for in-hospital mortality.

Results

In general, gastrectomies were mainly performed electively (total vs. subtotal 95% vs. 85%, p = 0.004). Patients having subtotal gastrectomy needed significantly more PRBC transfusions compared to total gastrectomy (p = 0.039). Most emergency surgeries were performed for benign diseases, such as ulcer perforations or bleeding and gastric ischaemia. Only emergency surgery was significantly associated with poorer overall survival (HR 2.68, 95% CI 1.32–5.05, p = 0.003).

Conclusion

In-hospital mortality was comparable between total and subtotal gastrectomies. Only emergency interventions increased postoperative fatality risk.
Stress Simulation on Cam-Type Transplanting Device of Semiautomatic Vegetable Transplanter
Authors: Markumningsih Sri , Hwang Seok-Joon , Kim Jeong-Hun , Jang Moon-Kyeong , Nam Ju-Seok
Published: December 2023

Stress measurements play a crucial role in safety analyses of transplanting devices. Strain gauges for stress measurements during field tests can be expensive and time-consuming. The aim of this study was to investigate the stress on the transplanting device of a cam-type semiautomatic vegetable transplanter using a simulation method. A three-dimensional simulation model was established, considering the dimensions and material properties of the transplanting device. The stress distribution and maximum stress values were obtained through simulations. The maximum stress values at 15 points within the transplanting device determined via the simulation were compared with the experimental stress data to verify the stress simulation model. The results show that the maximum stress obtained from the simulation correlated with that of the measured results, although differences were observed at different locations, particularly at strain gauge positions 11 and 13. Based on the simulation results, the maximum stress occurs at the upper link of the cam-type transplanting device, reaching a magnitude of 201.21 MPa, and the static safety factor is 1.04.
First Molecular Characterization of Small Ruminant Lentiviruses Detected in Romania
Authors: Olech Monika , Hodor Dragoş , Toma Corina , Negoescu Andrada , Taulescu Marian
Published: December 2023

Small ruminant lentiviruses (SRLVs) are a group of retroviruses that cause multisystem chronic diseases in goats and sheep and lead to production losses in these animals, negatively affecting animal health and welfare. Although molecular characterization of SRLV field isolates has been performed in many countries, there is currently no information on SRLV genotypes circulating in sheep and goats in Romania. Therefore, the main objective of this study was to conduct a molecular and phylogenetic analysis of SRLVs from Romania and determine the degree of genetic relatedness of the obtained sequences to other known SRLV reference strains. A total of 81 sheep lung tissue samples and 41 sheep lung lymph node samples were tested using nested real-time PCR, and samples positive for real-time PCR were used to amplify an 800 bp gag-pol fragment and an overlapping 625 bp fragment of the gag gene. Pairwise DNA distance and phylogenetic analysis showed that the Romanian SRLV strains were closely related to the A2 and A3 strains based on gag-pol sequences and to the A3 and A17 subtypes based on gag sequences. No recombination events were found. Our results revealed that the Romanian sequences have similar epitope patterns to other existing subtypes, although E/K and R/K mutations in epitope 3 were found only in the Romanian sequences, which may have potential value in serological diagnosis. This study is the first report on the genetic characterization of SRLV strains circulating in Romania and provides new information on SRLV heterogeneity. Further detailed studies should be conducted to better understand the divergence of SRLV Romanian strains.
In Ovo Feeding Techniques of Green Nanoparticles of Silver and Probiotics: Evaluation of Performance, Physiological, and Microbiological Responses of Hatched One-Day-Old Broiler Chicks
Authors: Ahmed Mervat M. N. , Ismail Zienhom S. H. , Elwardany Ibrahim , Lohakare Jayant , Abdel-Wareth Ahmed A. A.
Published: December 2023

The aim of this study was to investigate the effects of the in ovo feeding of green nanoparticles of silver (Nano-Ag), probiotics, and their combination on hatchability, carcass criteria and internal organs, biochemical parameters, and cecal microbial populations in hatched one-day-old chicks. On day 18 of incubation, 250 live embryo eggs were weighed and randomly assigned to one of five treatment groups: a negative control group, a positive control group consisting of chicks injected with 0.2 mL physiological saline, a group consisting of chicks injected with 0.2 mL Nano-Ag, a group consisting of chicks injected with 0.2 mL probiotics (Bifidobacterium spp.), and a group consisting of chicks injected with 0.2 mL combination of Nano-Ag and probiotics (1:1). The results showed that the in ovo injection of Nano-Ag or probiotics, alone or in combination, had no effect on hatchability, live body weight, or internal organs but improved (p < 0.05) chick carcass yield compared to the control groups. Furthermore, in ovo feeding decreased (p < 0.05) serum levels of cholesterol, triglycerides, urea, creatinine, alanine aminotransferase, and aspartate aminotransferase, as well as cecal E. coli, but increased Bifidobacterium spp. when compared to the control groups. Based on these findings, in ovo injections of green Nano-Ag and probiotics, either alone or in combination, have the potential to improve chick health and balance the microbial populations in hatched one-day-old chicks.
Prediction of Antibody Viscosity from Dilute Solution Measurements
Authors: Bhandari Kamal , Wei Yangjie , Amer Brendan R. , Pelegri-O’Day Emma M. , Huh Joon , Schmit Jeremy D.
Published: December 2023

The high antibody doses required to achieve a therapeutic effect often necessitate high-concentration products that can lead to challenging viscosity issues in production and delivery. Predicting antibody viscosity in early development can play a pivotal role in reducing late-stage development costs. In recent years, numerous efforts have been made to predict antibody viscosity through dilute solution measurements. A key finding is that the entanglement of long, flexible complexes contributes to the sharp rise in antibody viscosity at the required dosing. This entanglement model establishes a connection between the two-body binding affinity and the many-body viscosity. Exploiting this insight, this study connects dilute solution measurements of self-association to high-concentration viscosity profiles to quantify the relationship between these regimes. The resulting model has exhibited success in predicting viscosity at high concentrations (around 150 mg/mL) from dilute solution measurements, with only a few outliers remaining. Our physics-based approach provides an understanding of fundamental physics, interpretable connections to experimental data, the potential to extrapolate beyond training conditions, and the capacity to effectively explain the physical mechanics behind these outliers. Conducting hypothesis-driven experiments that specifically target the viscosity and relaxation mechanisms of outlier molecules may allow us to unravel the intricacies of their behavior and, in turn, enhance the performance of our model.
Characterization of Bending Strength in Similar and Dissimilar Carbon-Fiber-Reinforced Polymer/Aluminum Single-Lap Adhesive Joints
Authors: Bidadi Jamal , Saeidi Googarchin Hamed , Akhavan-Safar Alireza , Carbas Ricardo J. C. , da Silva Lucas F. M.
Published: December 2023

In recent years, the adhesive bonding method has gained increased attention, especially in the automotive industry, for constructing efficient body structures from dissimilar and lightweight materials such as aluminum and polymeric composites. Adhesively bonded automotive structures endure complicated loading conditions, including tensile and bending loading, during their service lives. To the best of the authors’ knowledge, there is no published work on the assessment of bending strength in single-lap adhesive joints (SLJs) when considering dissimilar adherends under three-point bending. In this study, three-point bend experiments were carried on the bending strength and the failure mechanisms of dissimilar SLJs made of carbon-fiber-reinforced polymer (CFRP) and aluminum substrates bonded with Araldite 2015 adhesive. Additional experiments were conducted individually on similar SLJs, including aluminum/aluminum and CFRP/CFRP, to investigate and compare the effects of adherend material type on the bending strength and failure behavior of SLJs. The results indicate that a CFRP/CFRP single-lap adhesive joint exhibits significantly higher joint strength in comparison to an aluminum/aluminum single-lap adhesive joint under three-point bending. The strength of dissimilar CFRP/aluminum single-lap joints usually falls between that of an aluminum/aluminum and that of a CFRP/CFRP single-lap adhesive joint. When the CFRP adherend is situated at the bottom of the joint in three-point bending, it imparts significantly greater joint strength and deformation compared to situations where the aluminum adherend is placed at the bottom.
Novel EMD with Optimal Mode Selector, MFCC, and 2DCNN for Leak Detection and Localization in Water Pipeline
Authors: Rajasekaran Uma , Kothandaraman Mohanaprasad , Pua Chang Hong
Published: December 2023

Significant water loss caused by pipeline leaks emphasizes the importance of effective pipeline leak detection and localization techniques to minimize water wastage. All of the state-of-the-art approaches use deep learning (DL) for leak detection and cross-correlation for leak localization. The existing methods’ complexity is very high, as they detect and localize the leak using two different architectures. This paper aims to present an independent architecture with a single sensor for detecting and localizing leaks with enhanced performance. The proposed approach combines a novel EMD with an optimal mode selector, an MFCC, and a two-dimensional convolutional neural network (2DCNN). The suggested technique uses acousto-optic sensor data from a real-time water pipeline setup in UTAR, Malaysia. The collected data are noisy, redundant, and a one-dimensional time series. So, the data must be denoised and prepared before being fed to the 2DCNN for detection and localization. The proposed novel EMD with an optimal mode selector denoises the one-dimensional time series data and identifies the desired IMF. The desired IMF is passed to the MFCC and then to 2DCNN to detect and localize the leak. The assessment criteria employed in this study are prediction accuracy, precision, recall, F-score, and R-squared. The existing MFCC helps validate the proposed method’s leak detection-only credibility. This paper also implements EMD variants to show the novel EMD’s importance with the optimal mode selector algorithm. The reliability of the proposed novel EMD with an optimal mode selector, an MFCC, and a 2DCNN is cross-verified with cross-correlation. The findings demonstrate that the novel EMD with an optimal mode selector, an MFCC, and a 2DCNN surpasses the alternative leak detection-only methods and leak detection and localization methods. The proposed leak detection method gives 99.99% accuracy across all the metrics. The proposed leak detection and localization method’s prediction accuracy is 99.54%, precision is 98.92%, recall is 98.86%, F-score is 98.89%, and R-square is 99.09%.
Lateral Control Calibration and Testing in a Co-Simulation Framework for Automated Vehicles
Authors: Bui Duc-Tien , Li Hexuan , De Cristofaro Francesco , Eichberger Arno
Published: December 2023

Lateral vehicle control is of high importance in automated vehicles as it directly influences the vehicle’s performance and safety during operation. The linear quadratic regulator (LQR) controller stands out due to its high-performance characteristics and is used in the open source for self-driving functions. However, a notable limitation of the current approach is the manual calibration of LQR controllers based on the experience and intuition of the designers, leading to empirical uncertainties. To address this issue and enhance the lateral control performance, this paper concentrates on refining the LQR by employing three optimization algorithms: artificial bee colony optimization (ABC), genetic algorithm (GA), and particle swarm optimization (PSO). These algorithms aim to overcome the reliance on empirical methods and enable a data-driven approach to LQR calibration. By comparing the outcomes of these optimization algorithms to the manual LQR controller within an offline multibody simulation as a testing platform, this study highlights the superiority of the best-performing optimization approach. Following this, the optimal algorithm is implemented on a real-time system for the full vehicle level, revealing the model-in-the-loop and the hardware-in-the-loop gap up to 78.89% with lateral velocity when we use the relative error criterion (REC) method to validate and 2.35 m with lateral displacement when considering the maximum absolute value method.
Advancing Dimethacrylate Dental Composites by Synergy of Pre-Polymerized TEGDMA Co-Filler: A Physio-Mechanical Evaluation
Authors: Alrahlah Ali , Khan Rawaiz , Al-Odayni Abdel-Basit , Saeed Waseem Sharaf , Bautista Leonel S. , Alnofaiy Ibraheem A. , De Vera Merry Angelyn Tan
Published: December 2023

Dental resin composites (DRCs) have gained immense popularity as filling material in direct dental restorations. They are highly valued for their ability to closely resemble natural teeth and withstand harsh oral conditions. To increase the clinical performance of dental restorations, various fillers are incorporated into DRCs. Herein, the effect of incorporating pre-polymerized triethylene glycol dimethacrylate (P-TEGDMA) as a co-filler in varying proportions (0%, 2.5%, 5%, and 10% by weight) into bisphenol A-glycidyl methacrylate (BisGMA)/TEGDMA/SiO2 resin composite was investigated. The obtained DRCs were examined for morphology, rheological properties, degree of crosslinking (DC), Vickers microhardness (VMH), thermal stability, and flexural strength (FS). The results revealed that SiO2 and P-TEGDMA particles were uniformly dispersed. The introduction of P-TEGDMA particles (2.5 wt.%) into the resin composite had a remarkable effect, leading to a significant reduction (p ≤ 0.05) in complex viscosity, decreasing from 393.84 ± 21.65 Pa.s to 152.84 ± 23.94 Pa.s. As a result, the DC was significantly (p ≤ 0.05) improved from 61.76 ± 3.80% to 68.77 ± 2.31%. In addition, the composite mixture demonstrated a higher storage modulus (G′) than loss modulus (G″), indicative of its predominantly elastic nature. Moreover, the thermal stability of the DRCs was improved with the addition of P-TEGDMA particles by increasing the degradation temperature from 410 °C to 440 °C. However, the VMH was negatively affected. The study suggests that P-TEGDMA particles have the potential to be used as co-fillers alongside other inorganic fillers, offering a means to fine-tune the properties of DRCs and optimize their clinical performance.
Anti-Adhesive Surfaces Inspired by Bee Mandible Surfaces
Authors: Saccardi Leonie , Schiebl Jonas , Balluff Franz , Christ Ulrich , Gorb Stanislav N. , Kovalev Alexander , Schwarz Oliver
Published: December 2023

Propolis, a naturally sticky substance used by bees to secure their hives and protect the colony from pathogens, presents a fascinating challenge. Despite its adhesive nature, honeybees adeptly handle propolis with their mandibles. Previous research has shown a combination of an anti-adhesive fluid layer and scale-like microstructures on the inner surface of bee mandibles. Our aim was to deepen our understanding of how surface energy and microstructure influence the reduction in adhesion for challenging substances like propolis. To achieve this, we devised surfaces inspired by the intricate microstructure of bee mandibles, employing diverse techniques including roughening steel surfaces, creating lacquer structures using Bénard cells, and moulding resin surfaces with hexagonal patterns. These approaches generated patterns that mimicked the bee mandible structure to varying degrees. Subsequently, we assessed the adhesion of propolis on these bioinspired structured substrates. Our findings revealed that on rough steel and resin surfaces structured with hexagonal dimples, propolis adhesion was significantly reduced by over 40% compared to unstructured control surfaces. However, in the case of the lacquer surface patterned with Bénard cells, we did not observe a significant reduction in adhesion.
Evaluation of Antidepressant Activity of Capsaicin Nanoemulsion in Nicotine Withdrawal-Induced Depression in Mice
Authors: Krishnamoorthy Naveen Kumar , Roohi Tamsheel Fatima , Peddha Muthukumar Serva , Kinattingal Nabeel , Wani Shahid Ud Din , Krishna Kamsagara Linganna , Shakeel Faiyaz , Mehdi Seema
Published: December 2023

Depression is a low-energy condition that has an impact on a person’s thoughts, actions, propensities, emotional state, and sense of wellbeing. According to the World Health Organization (WHO), 5% of adults are depressed. Individuals who are depressed are commonly prescribed antidepressants, and sometimes, individuals may have other psychiatric conditions that share overlapping symptoms with depression. These cooccurring conditions can complicate the diagnostic process, leading to a misdiagnosis and the prescription of antidepressants. Capsaicin (CAP) is a known antidepressant. Hence, this study aimed to assess the antidepressant activity of CAP nanoemulsion in nicotine (NC) withdrawal-induced depression in mice. Mice treated with CAP (3 mg/kg) showed reduced immobility in the forced swimming test (FST), tail-suspension test (TST), and open field test (OFT). During the OFT, the animals treated with nanoemulsion (CAP 3 mg/kg) spent less time in the corners than the control animals. Biochemical parameters, such as superoxide dismutase (SOD) and glutathione (GSH), were observed in reduced quantities in the NC withdrawal model (NWM), where they were slightly increased in the high-dose nanoemulsion (CAP 3 mg/kg) compared to the low-dose nanoemulsion (CAP 1 mg/kg). These results suggest that CAP caused antidepressant activity in the NWM via the nanoemulsion.
A Timber–Concrete–Composite Edge Connection for Two-Way Spanning Cross-Laminated Timber Slabs—Experimental Investigations and Analytical Approach
Authors: Stieb Thomas , Maderebner Roland , Dietsch Philipp
Published: December 2023

This paper introduces a method to create a moment-resisting edge connection between two cross-laminated timber (CLT) panels. With this connection, two-way spanning cross-laminated timber slabs can be realised, where the span exceeds the manufacturing and transport-related width of the individual CLT panels. Until now, mostly on-site gluing solutions have been suggested for such connections. In this study, a solution using a timber–concrete–composite (TCC) system is proposed. For this, self-tapping screws are inserted along the edge face of the CLT component, enabling the formation of a lap splice between two adjacent CLT elements. This lap splice is reinforced by additional rebars and filled with concrete. This means that only familiar, easy-to-handle materials are used on-site, and there is no need for adhesives, which can be difficult to apply. To evaluate the load-bearing capacity of the connection, it was subjected to a pure bending load in four-point bending tests, where load-bearing capacities of up to 70% of the characteristic load-bearing capacity of the solid CLT elements were achieved. An analytical approach for a simplified engineering calculation model is introduced to determine the load acting upon the screws. Based on the experimental results, it is shown that the analytical approach is able to adequately represent the load-bearing capacity of the connection. The analytically determined forces on the screws may then be used to carry out further verifications on this connection method.
An Output-Only, Energy-Based, Damage Detection Method Using the Trend Lines of the Structural Acceleration Response
Authors: Kordestani Hadi , Zhang Chunwei , Arab Ali
Published: December 2023

Using the trendlines of an acceleration response as a tool to decompose a structural response is a new topic that was proposed by authors in 2020. This paper provides a numerical/experimental investigation of using a Savitzky–Golay filter (SGF) in a method to calculate the trendline and decompose building acceleration responses when subjected to a seismic load. Hence, this paper proposes an output-only, energy-based, damage detection method in which the trend lines of a building’s structural acceleration responses are used to locate the damage. For this purpose, an adjusted SGF is utilized to calculate an especial trend line for each floor’s acceleration response of the building structural model. The energy of these trend lines is then calculated and normalized. Two damage indices are used, of which, the second one is being proposed for the first time in this paper. The accuracy of the proposed method is numerically and experimentally investigated using a five-floor building structural model subjected to white noise excitation through a shake table. The results prove that the proposed method is capable of accurately locating and quantifying structural damages with a severity of more than 10% in a noisy environment. In view that the proposed method locates the damage with no need of determining the structural modal properties or parameters, it can be categorized as an online and quick structural damage detection method.
Methyl Orange Adsorption on Biochar Obtained from Prosopis juliflora Waste: Thermodynamic and Kinetic Study
Authors: Diaz-Uribe Carlos , Ortiz Jarith , Duran Freider , Vallejo William , Fals Jayson
Published: December 2023

In the information contained herein, we fabricated biochar by means of a pyrolysis process; it used Prosopis juliflora waste (PJW) as a biomass source. The physical and chemical material characterization was carried out through FTIR, thermogravimetric, BET-N2 isotherm, and SEM-EDX assays. We studied the methylene orange (MO) adsorption onto PWJ biochar. The PJW biochar displayed a maximum percentage of MO removal of 64%. The results of the adsorption study indicated that Temkin isotherm was suitable to describe the MO adsorption process on PJW biochar; it suggests that the MO adsorption on PJW biochar could be a multi-layer adsorption process. Results showed that the pseudo-second-order model was accurate in demonstrating the MO adsorption on PJW (k2 = 0.295 g mg−1min−1; qe = 8.31 mg g−1). Furthermore, the results made known that the MO removal by PJW biochar was endothermic (ΔH = 12.7 kJ/mol) and a spontaneous process (ΔG = −0.954 kJ/mol). The reusability test disclosed that after four consecutive adsorption/desorption cycles, the PWJ biochar reduced its MO removal by only 4.3%.