bluuebunny/crossref_metadata_2025 huggingface dataset:
Human papillomavirus (HPV) genotypes and associated cervical disease in an anti-retroviral setting in Accra, Ghana
Authors: Amelor Dodzi , Donkoh Emmanuel Timmy , Asmah Richard Harry , Nortey Priscilla , Oppong Samuel , Wiredu Edwin K
Published: February 2022

Background
The vast majority of women diagnosed with HIV/AIDS are found in the Sub-Saharan African region. These women have a high chance of being infected with human papillomaviruses (HPV), which causes cervical cancer and precursor lesions. Early initiation of HAART coupled with a high HAART compliance may reduce disease burden, but in Ghana, little is known about the distribution of HPV infections and epithelial changes in this vulnerable group.
Methods
This work was carried out to establish the distribution of genital HPV genotypes among women living with HIV attending a special HIV outpatient clinic at the Korle-Bu Teaching hospital Accra, Ghana. Pap smears were performed for 538 selected women. A highly sensitive nested multiplex PCR (NMPCR) assay was conducted for the detection and typing of human papillomavirus (HPV) genotypes. These included, 6/11, 16,18, 31, 33, 35, 39, 42, 43, 44, 45, 51, 52, 56, 58, 59, 66, and 68. Cervical smears were examined for cytologic abnormalities by two cytologists and verified by a pathologist.
Results
Coverage of HAART in this population was 84%. HPV DNA was detected in 280 out of the 538 individuals studied, 52.0% (95%CI 47.7–56.3). Out of these 129 (46.1%, 95%CI 40.1–52.1) had multiple HPV infections and 151 (53.9%, 95%CI 47.9–59.9) had single infections. The prevalence of LR HPV was 10.2% (95% CI: 11.3–17.6). while that of HR HPV was 29.7% (95% CI: 27.4–35.7). The commonest HR types were, 35 ,18 ,58 ,52 and 45 in descending order. The frequency of HPV 16 was 2.4%. Cytologically, 2.8% had ASCUS, 3.9% LGSIL and 2.8% HGSIL, none of the women was found to have atypical glandular cells or adenocarcinoma. The commonest HPV genotypes detected among women with ASCUS were HPV-18 (25% of all ASCUS cases), 52 (25% of all ASCUS cases) and 68 (25% of all ASCUS cases). Among women with LSIL most prevalent were HPV-52 (66.5% of all LSIL cases), HPV-18 (22.2% of all LSIL cases) and HPV 45 (22.2% of all LSIL cases). HPV-16, 52 and 42 were each found in 50% of all High-grade lesions., being the top three in that order for high grade intraepithelial/severe dysplasia lesions
Conclusions
There is a high burden of HPV infection in women living with HIV attending clinic at the KBTH. Given the high prevalence of HIV-HPV coinfection despite the high coverage of HAART, associated cervical lesions represent a major public health burden. These results show that currently available prophylactic vaccines have the potential to be useful in the primary prevention of HPV infections among immunocompromised women. This study also found a cross-sectional association between early age at first sex and the presence of precancerous cervical lesions. Efforts to make vaccines available to young girls before sexual debut should be prioritized along with education on safe sexual habits.
CpG ODN (K3)—Toll-Like Receptor 9 Agonist—Induces Th1-type Immune Response and Enhances Cytotoxic Activity in Advanced Lung Cancer Patients: A Phase I Study
Authors: Otsuka Tomoyuki , Nishida Sumiyuki , Shibahara Takayuki , Temizoz Burcu , Hamaguchi Masanari , Shiroyama Takayuki , Kimura Keiko , Miyake Kotaro , Hirata Haruhiko , Mizuno Yumiko , Yagita Mayu , Manabe Yusuke , Kuroda Etsushi , Takeda Yoshito , Kida Hiroshi , Ishii Ken J , Kumanogoh Atsushi
Published: February 2022

Background: Cytosine-phosphate-guanine oligodeoxynucleotide (CpG ODN) (K3)—a novel synthetic single-stranded DNA immune adjuvant for cancer immunotherapy—induces a potential Th1-type immune response against cancer cells. We conducted a phase I study of CpG ODN (K3) in patients with lung cancer to assess its safety and patients’ immune responses. Methods: The primary endpoint was the proportion of dose-limiting toxicities (DLTs) at each dose level. Secondary endpoints included safety profile, an immune response, including dynamic changes in immune cell and cytokine production, and progression-free survival (PFS). In a 3 + 3 dose-escalation design, the dosage levels for CpG ODN (K3) were 5 or 10 mg/body via subcutaneous injection and 0.2 mg/kg via intravenous administration on days 1, 8, 15, and 29. Results: Nine patients (eight non-small-cell lung cancer; one small-cell lung cancer) were enrolled. We found no DLTs at any dose level and observed no serious treatment-related adverse events. The median observation period after registration was 55 days (range: 46-181 days). Serum IFN-a2 levels, but not inflammatory cytokines, increased in six patients after the third administration of CpG ODN (K3) (mean value: from 2.67 pg/mL to 3.61 pg/mL after 24 hours). Serum IFN-g (mean value, from 9.07 pg/mL to 12.7 pg/m after 24 hours) and CXCL10 levels (mean value, from 351 pg/mL to 676 pg/mL after 24 hours) also increased in eight patients after the third administration. During the treatment course, the percentage of T-bet-expressing CD8+ T cells gradually increased (mean, 49.8% at baseline and 59.1% at day 29, p = 0.0273). Interestingly, both T-bet-expressing effector memory (mean, 52.7% at baseline and 63.7% at day 29, p = 0.0195) and terminally differentiated effector memory (mean, 82.3% at baseline and 90.0% at day 29, p = 0.0039) CD8+ T cells significantly increased. The median PFS was 398 days. Conclusions: This is the first clinical study showing that CpG ODN (K3) activated innate immunity and elicited Th1-type adaptive immune response and cytotoxic activity in cancer patients. CpG ODN (K3) was well tolerated at the dose settings tested, although the maximum tolerated dose was not determined. Trial registration: UMIN-CTR number 000023276. Registered 1 September 2016, https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000026649
Attitude and Utilization of Non-Pharmacological Labor Pain Management among Obstetrics Care Providers in Harari Regional State Health Facilities, Ethiopia.
Authors: Eyeberu Addis , Debela Adera , Getachew Tamirat , Dheresa Merga , Alemu Addisu , Dessie Yadeta
Published: February 2022

Background: In a woman’s life, labor pain is the most severe pain that they have ever face. In Ethiopia, the provision of pain relief in labor is often neglected. Furthermore, evidence strongly urged that further research is needed on non-pharmacological labor pain management. Therefore, healthcare providers’ attitudes and utilization of non-pharmacological labor pain management need to be assessed. Method: A facility-based cross-sectional study was conducted from May 20 to June 10, 2021, in Harari regional state health facilities, Ethiopia. All obstetric caregivers in Harari regional state health facilities were included in the study. A structured questionnaire adapted from the previous studies was used to collect data. The data was entered into Epi-data version 3.1 statistical software. Statistical analysis was carried out by using SPSS for windows version 22. Multivariate linear regression analysis was employed to determine the association between independent variables and the outcome variable.Result: The overall utilization of non-pharmacological labor pain relief methods was 59.3% [(95% CI (53.9,63.4)]. Three hundred five (65.5%) of the study participants had unfavorable attitudes. Females compared to males (β= -0.420; 95% CI: -0.667, -0.173), clinical experience (β= -0.201; 95% CI: -0.268, -0.134), knowledge sum score (β =0.227: 95%; CI: 0.18,0.247), and attitude sum score (β=0.376; 95% CI: 0.283, 0.47) were showed significantly association with utilization of non-pharmacological labor pain management.Conclusion: The overall utilization of non-pharmacological labor pain relief methods was relatively good compared to other studies done in Ethiopia but all women’s need for labor relief methods should not be ignored. In this study sex of the respondents, clinical experience, individual preference, attitude and knowledge were factors associated with utilization of non-pharmacological labor pain management. All stake holds need to work together to improve the attitude of health providers and to increase utilization of non-pharmacologic labor pain management.
Effect of a short-term light stress on resistance, signaling, metabolism, and cell division of Ulva prolifera revealed by omics
Authors: Gu Kai , Liu Yuling , Jiang Ting , Cai Chuner , Zhao Hui , Liu Xuanhong , He Peimin
Published: February 2022

Ulva prolifera is the main species of green tide algae in the Yellow Sea, China, and its growth process is significantly affected by light intensity. The work used four omics to reveal the molecular mechanism of U. prolifera responding to high light. Four-omics conjoint analysis showed the interconversion of sugars in the algae, fatty acid synthesis, steroid synthesis, photosynthesis, pyrimidine metabolism and carbohydrate metabolism. After 12 hours of high light, the photosynthetic capacity of U. prolifera increased and the carbon sequestration mode changed from C3 pathway to C4 pathway. At the same time, the glucose metabolism pathway was enhanced, but the energy metabolism pathway was weakened, and the overall energy consumption showed a decreasing trend. Different resistance modes have different response mechanisms to high light stress. In addition, the growth, development and reproduction of U. prolifera were inhibited, indicating that U. prolifera may be in a dormant state after 12 hours of hight light stress, reducing energy consumption caused by unnecessary developmental physiological processes. The response mechanism of U. prolifera to high light stress was preliminarily obtained through the combined analysis of four kinds of omics, which provided the basis for future research.
A Hybrid Strategy for Reduction in Time Consumption for Cloud Datacenter Using HMBC Algorithm
Authors: ullah ARIFULLAH , Alam Tanweer , Aziza Chakir , Sebai Dorsaf , Abualigah Laith
Published: February 2022

Cloud technology is a utility where different hardware and software resources are accessed on pay-per-user ground base. Most of these resources are available in virtualized form and virtual machine (VM) is one of the main elements of visualization. In virtualization, a physical server changes into the virtual machine (VM) and acts as a physical server. Due to the large number of users sometimes the task sent by the user to cloud causes the VM to be under loaded or overloaded. This system state happens due to poor task allocation process in VM and causes the system failure or user tasks delayed. For the improvement of task allocation, several load balancing techniques are introduced in a cloud but stills the system failure occurs. Therefore we hybrid modified artificial bee colony for improvement in task allocation of VM and minimizing time consummation in cloud datacenter like makespan, total processing time, response time of algorithms, response time of datacenter and degree of imbalance. The consequences of the proposed task scheduling algorithm are matched with existing heuristic-based scheduling procedures. The experimental consequences demonstrate that our approach is efficient when it is compared with the existing algorithms and reduce 1.7 % in time consumption for cloud datacenter.
Declining Importance of Herbivores in Structuring a Heavily Impacted Urban Coral Reef near Cartagena Bay, Colombia
Authors: Shantz Andrew , López-Londoño Tomás , Gomez-Campo Kelly , Iglesias-Prieto Roberto , López-Victoria Mateo , Medina Mónica
Published: February 2022

Coral reefs are beginning to experience conditions unlike any in recent history. Understanding ecosystem function on future reefs will require reassessing ecological processes under novel environmental regimes. For many coastal reefs, severely degraded water quality will be a hallmark of these novel regimes. While herbivory has traditionally been considered essential for maintaining coral dominance recent evidence from urban reefs suggests this pattern may be changing. Here, we reexamined the importance of herbivory on a shallow, turbid reef exposed to extensive coastal development. We found that although herbivore biomass, size-structure, and grazing rates were significantly reduced relative to a nearby protected reef, coral cover on this shallow urban reef remained > 45%. In contrast, coral cover at the nearby protected site was roughly 50% lower. Differences in coral cover between the sites were due to greater cover of two groups of corals at the urban site: depth-generalist Orbicella spp. (O. faveolate and O. annularis), and weedy species Agaricia spp. Both groups are tolerant of low light levels but susceptible to coral bleaching. Our results suggest that diminished top-down pressure did not promote algal dominance. Instead, turbidity-induced reductions in available light drove community structure, leading to dominance of coral and algae species able to acclimate to low-light. Our study demonstrates how environmental context can alter the importance of critical processes on coral reefs and highlights the need to reexamine traditional paradigms in reef ecology to understand ecosystem function on future reefs.
Investigating the Susceptibility of Treatment-Resistant Oesophageal Tumours to Natural Killer Cell-Mediated Responses.
Authors: Mylod Eimear , Mckenna Ellen , Davern Maria , Barr Martin P , Donlon Noel E , Bibby Becky AS , Bhardwaj Anshul , Reynolds John V , Lysaght Joanne , Maher Stephen G. , Conroy Melissa J.
Published: February 2022

Introduction: The majority of oesophageal adenocarcinoma (OAC) patients do not respond to multimodal treatment regimens and face dismal survival rates. Natural killer (NK) cells are crucial anti-tumour immune cells, and this study investigated the susceptibility of treatment-resistant OAC cells to these potent tumour killers.Methods: Natural killer receptor (NKR) ligand expression by OE33CisP (cisplatin-sensitive) and OE33CisR (cisplatin-resistant) cells was investigated. The immunomodulatory effects of OE33CisP and OE33CisR cells on NK cell phenotype and function were assessed. Finally, the impact of chemotherapy regimens on NKR ligand shedding was examined.Results: Our data revealed significantly less surface expression of activating ligands B7-H6, MICA/B, ULBP-3 and activating/inhibitory ligands PVRL-1 and PVRL-4 by OE33CisR cells, compared to OE33CisP cells. Co-culture with OE33CisR cells reduced the frequencies of Nkp30+ and NKp46+ NK cells and increased frequencies of TIGIT+, FasL+ and TRAIL+ NK cells. Frequencies of IFN-γ-producing NK cells increased while frequencies of TIM-3+ NK cells decreased after culture with OE33CisP and OE33CisR cells. Frequencies of circulating NKP30+ NK cells were significantly lower in OAC patients with the poorest treatment response and in patients who received FLOT chemotherapy. B7-H6 shedding by OAC tumour cells was induced by FLOT.Conclusion: OE33CisR cells express less activating NKR ligands than OE33CisP cells and have differential effects on NKR expression by NK cells. However, neither cell line significantly dampened NK cell cytokine production, death receptor expression or degranulation. Finally, our data indicate that FLOT chemotherapy and obesity may promote B7-H6 shedding and immune evasion with detrimental consequences in OAC patients.
EFFECTS OF TWO TYPES OF CONTROLLABLE DEFORMATION ON ENERGY EXTRACTION OF A FLEXIBLE HYDROFOIL
Authors:   School of Mechanical Engineering, Shandong University, Jinan, Shandong 250061, China, Zhang Yubing , Wang Yong , Sun Guang , Han Jiazhen , Xie Yudong ,   Key Laboratory of High-efficiency and Clean Mechanical Manufacture, Shandong University, Ministry of Education, Jinan, Shandong 250061, China
Published: February 2022

Energy extraction capacity of controllably flexible hydrofoil was studied under two identified deformation modes. Deformation modes, flexure parameters (flexure amplitude  and flexure coefficient ) and motion parameters (reduced frequency f* and pitching amplitude 0) were investigated to understand the effects of controllably flexible deformation on energy extraction. The results reveal that deformation modes affect the effective angle of attack and vortex structure, which influence hydrodynamic performance. The energy extraction capacity improves from the deformation mode 2 to the rigid hydrofoil and then to the deformation mode 1. Under the deformation mode 1, lift, moment and power coefficients are increased obviously with the increase of , while they increase slightly with . Power coefficients and efficiency are sensitive to , which influences the development of leading-edge vortices. The flexible coefficient  affects the wake structure, which has less impact on variation of force coefficient. As the increase in f*, averaged power coefficients firstly increase and then decrease. Further, the optimal f* is subjected to 0. Interestingly, a critical reduced frequency f*s, which is generally increase with increasing 0, was found under three modes. The condition that f* > f*s. is a prerequisite for subsequent adjustments of flexure modes and parameters according to different requirement of power coefficient under different tidal currents. The range of high efficiency () is: deformation mode 1 (36.1%<<54.3%) > rigid hydrofoils (34.2%<<41%) > deformation mode 2 (26.9%<<30.3%).
Entanglement Negativity in Flat Holography
Authors: Basu Debarshi , Chandra Ashish , Parihar Himanshu , Sengupta Gautam
Published: February 2022

We advance holographic constructions for the entanglement negativity of bipartite states in a class of (1+1)-dimensional Galilean conformal field theories dual to asymptotically flat three dimensional bulk geometries described by Einstein Gravity and Topologically Massive Gravity. The construction involves specific algebraic sums of the lengths of bulk extremal curves homologous to certain combinations of the intervals appropriate to such bipartite states.
Our analysis exactly reproduces the corresponding replica technique results in the large central charge limit. We substantiate our construction through a semi classical analysis involving the geometric monodromy technique for the case of two disjoint intervals in such holographic Galilean conformal field theories.
A REGRESSIVIDADE DEMOCRÁTICA DA BNCC
Authors: Mendes da Silva Itamar , Giovedi Valter Martins
Published: February 2022

Este artigo consiste em análise documental que evidencia o desrespeito à Constituição Federal e à LDBEN/96 efetivado na BNCC (Base Nacional Comum Curricular). Afirma-se que a BNCC, como documento de caráter normativo, impõe uma única concepção pedagógica e curricular: a Pedagogia e o Currículo por Competências. Ao fazê-lo, desrespeita os princípios constitucionais da pluralidade de concepções pedagógicas, da liberdade de ensinar e aprender e o da autonomia das escolas na construção de suas propostas pedagógicas.
Тревога и неопределенность в межкультурном взаимодействии: экспериментальное исследование
Authors: Хухлаев Олег Е. , Браткина Мария А.
Published: February 2022

Введение. В статье представлены результаты экспериментального исследования вклада тревоги и неопределенности в межкультурное взаимодействие, рассмотренного в контексте теории управления беспокойством/неопределенностью У. Гудиканста. Несмотря на наличие корреляционных исследований, подтверждающих базовые положения теории, экспериментально изучены только предпосылки желания взаимодействовать с представителями людьми иной культуры, которое является одной из характеристик эффективного межкультурного взаимодействия. Более представленным в теории управления беспокойством/неопределенностью критерием эффективности межкультурного общения является воспринимаемая эффективность межкультурного общения, ранее экспериментально не изученная. Эксперимент был нацелен как на проверку гипотезы о существовании прямого эффекта ситуаций неопределенности и тревоги на воспринимаемую эффективность межкультурного взаимодействия, так и на изучение опосредования данного влияния воспринимаемой предсказуемостью межкультурного общения и воспринимаемой межгрупповой тревогой. Методы. В исследовании использован экспериментальный дизайн 2 (манипуляция неопределенностью) × 2 (манипуляция тревогой). В качестве зависимых переменных выступали воспринимаемая предсказуемость межкультурного общения, межгрупповая тревога и воспринимаемая эффективность межкультурного взаимодействия в предполагаемом общении с партнером из Колумбии. Всего в эксперименте приняло участие 92 человека, возраст от 18 до 44 лет, 78 % из которых составляли женщины. Эксперимент проходил онлайн, на платформе для видеоконференций Zoom. Результаты. Проверка гипотез была осуществлена с помощью медиационного анализа, основанного на регрессиях. Экспериментально продемонстрированы непрямые эффекты ситуации неопределенности и тревоги на воспринимаемую эффективность межкультурной коммуникации. При этом данная связь опосредована воспринимаемой предсказуемостью и воспринимаемой межгрупповой тревогой. Обсуждение результатов. Результаты исследования соответствуют предположениям теории управления беспокойством/неопределенностью У. Гудиканста и выступают ее первым экспериментальным подтверждением. При этом показано, что тревога и неопределенность являются разными путями обеспечения эффективности межкультурного общения.
DESCRIÇÃO CONSTRUTIVA DE MINIBAR COMPACTO PARA COWORKING
Authors: Debora Eloise Sperandio  , Samantha Gollnick  , Aline Effting Guedes  , Amanda Guesser Nazário  , Carlos Eduardo Senna  , Sérgio Henrique Prado Scolari
Published: February 2022

Espaços de trabalho colaborativos, conhecidos como coworking, são cada vez mais comuns nas cidades brasileiras. Nesses espaços são valorizados diferentes elementos, com o intuito de estabelecer ações internas de interação. Estudar e compreender esses ambientes são de suma importância para o designer, que pode propor novas soluções técnicas de modo a atender às demandas de mercado. O presente artigo descreve parte do processo de concepção de um móvel do tipo minibar compacto, pensado para uso durante reuniões informais ou momentos de descontração. O produto em questão apresenta disposição construtiva que garante benefícios de praticidade. Tal característica tornou-se evidente por meio da busca de anterioridade, que foi realizada para conhecimento do estado da técnica.
O ENSINO DO DESIGN: DESAFIOS PARA A FORMAÇÃO PROFISSIONAL
Authors: Flavia Lumi Matuzawa  , Miriam Nathalie Ferreira Fortuna  , Berenice Santos Gonçalves
Published: February 2022

A acelerada evolução da tecnologia trouxe novos desafios para as práticas pedagógicas, demandando um replanejamento da sociedade e da educação para acompanhar esse processo contínuo. Diante de tantas transformações é importante refletir sobre a base da formação de designers para encontrar meios de adequá-los ao perfil contemporâneo. Nesse sentido, este artigo apresenta uma análise de referenciais provenientes de dois relatórios mundiais e diretrizes curriculares legitimadas que tratam do ensino superior. Discutem-se os principais desafios identificados nesses relatórios, procurando apontar iniciativas existentes nas diretrizes e destacar elementos que podem refletir na formação e na prática do futuro designer. A contribuição deste artigo reside nos subsídios apontados na discussão das informações apresentadas como um convite a estudos mais aprofundados para prover meios de formar indivíduos no nível superior, utilizando abordagens interdisciplinares e multivariadas que dominem diferentes competências em amplos aspectos – sociais, tecnológicos, econômicos, ambientais e políticos.
DESENVOLVIMENTO E CRIAÇÃO DAS PERSONAGENS DO JOGO ROUTE RAIDERS E IDENTIFICAÇÃO DO PERFIL DOS USUÁRIOS NO CENÁRIO PÓS-PANDÊMICO
Authors: Maria Eduarda Cardoso  , Gabriela Corbani Ribeiro  , Marli Teresinha Everling  , Viviane Cris Mendes Xavier  , José Francisco Pelegrino Xavier
Published: February 2022

Este artigo relata a criação e o desenvolvimento de personagens do jogo Route Raiders, além de identificar o perfil dos usuários no cenário pós-pandêmico. O jogo Route Raiders tem como propósito ressaltar a história local de cidades mediante pontos turísticos por meio de rotas gamificadas. Por causa da pandemia do coronavírus, ocorreram algumas mudanças nos locais públicos, transformando a forma como os sujeitos se relacionam, gerando medos e inseguranças. Utilizaram-se como instrumento para a criação das personagens fichas com critérios específicos, além do método de pesquisa bibliográfica para a fundamentação do estudo contendo a teoria dos cinco grandes fatores de Gordon Allport e transtornos da personalidade da quinta edição do Manual Diagnóstico e Estatístico de Transtornos Mentais. Foram elaboradas 165 personagens, sendo 15 para cada localidade: Joinville, Balneário Camboriú, Araquari, Itapoá, Vila da Glória, São Francisco do Sul, Campo Alegre, Florianópolis, Balneário Barra do Sul e Garuva, em Santa Catarina, e no Paraná a cidade de Curitiba. O turismo foi envolvido, levando-se em conta o contexto da pandemia da Covid-19, os impactos psicológicos sofridos pelo usuário durante a pandemia e uma hipótese do cenário pós-pandêmico. Com isso, espera-se agregar conhecimento acerca da identificação do perfil do usuário no pós-pandemia, bem como contribuir com a sensibilização para o patrimônio cultural de diferentes cidades por meio da criação de personagens.
SPHAN/Pró-Memória: abertura política e novos rumos para a preservação do patrimônio nacional
Authors: Miriane da Costa Peregrino
Published: February 2022

Uma breve comparação entre as políticas públicas de preservação do patrimônio cultural nacional entre 1960 e 80 evidencia uma mudança não só de objeto mas de discurso. O processo de abertura política e o dinamismo de Aloísio Magalhães foram aspectos fundamentais para a inclusão da pluralidade cultural na agenda oficial da cultura, caracterizando os novos rumos das políticas nesse setor. No entanto as páginas da história da institucionalização da cultura no Brasil no século XX são escritas com dificuldade, em virtude da escassez de fontes primárias disponíveis. O pesquisador da cultura que tenta ou efetivamente se debruça sobre essas fontes encontra pelo menos três problemas: falta de organização de arquivos institucionais, lacunas documentais − decorrentes em alguns casos da má preservação do patrimônio documental − e, consequentemente, indisponibilidade de acesso. Dessa forma, as oportunidades de trabalhar com a documentação do Conselho Nacional de Cultura (CNC), do Conselho Federal de Cultura (CFC), do Conselho Nacional de Política Cultural (CNPC), da Secretaria do Patrimônio Histórico e Artístico Nacional (SPHAN) e da Fundação Nacional Pró-Memória/Pró-Memória (SPHAN/Pró-Memória) – no âmbito dos programas de bolsas de pesquisa na Fundação Casa de Rui Barbosa (FCRB) e no Instituto do Patrimônio Histórico e Artístico Nacional (IPHAN) – foram valiosas. O presente artigo visa contribuir para uma redação dessa história, utilizando os arquivos dessas instituições, já extintas, como fonte, além de bibliografia sobre o assunto.
Memória e poder: mulheres artistas nas exposições museológicas no Brasil e em Portugal
Authors: Rebecca Corrêa e Silva  , Ursula Rosa da Silva
Published: February 2022

O presente artigo apresenta uma reflexão a respeito do papel do museu como instituição que reelabora e transmite valores e significados do patrimônio, devolvendo-os para a sociedade. Nesse aspecto, destacamos a exposição museológica enquanto veículo primordial de comunicação com o público, enfatizando sua contribuição para a construção de novas miradas sobre o patrimônio produzido por mulheres artistas. Partindo de uma perspectiva que integra sociomuseologia e gênero, fizemos uma análise comparativa de duas exposições museológicas recentes, realizadas no Brasil e em Portugal, que expuseram exclusivamente obras de mulheres artistas: O Museu Sensível – Uma Visão da Produção de Artistas Mulheres na Coleção do MARGS (Brasil) e Museu no Feminino – Mulheres Artistas na Coleção do MFTPJ (Portugal). Além da pesquisa historiográfica e qualitativa, foram entrevistados os diretores-curadores do Museu de Arte do Rio Grande do Sul Ado Malagoli (MARGS) e do Museu Francisco Tavares Proença Júnior (MFTPJ) quanto às respectivas exposições abordadas neste estudo, a fim de complementar as informações obtidas sobre os dois casos e propiciar a fundamentação para a análise comparativa.
Del legado institucional al modelo relacional: una exploración de la trayectoria reciente del Museo Municipal de Arte Decorativo Firma y Odilo Estévez (Rosario, Argentina, 1968-2010)
Authors: Horacio Miguel Hernán Zapata
Published: February 2022

El artículo busca contribuir a la reflexión sobre el papel del museo como una institución en la que actúan, simultáneamente, en las tareas de conservación, exhibición y difusión de un patrimonio artístico e histórico cuya misión es generar relatos acerca de ese patrimonio. Como estudio de caso, el artículo explora la trayectoria reciente del Museo Municipal de Arte Decorativo Firma y Odilo Estévez de la ciudad de Rosario (Argentina), desde una perspectiva que conjuga los aportes de la historia social y de los estudios museológicos del patrimonio cultural. Se centra en algunos de los cambios que se vienen dando en el museo, desde su instalación como entidad pública en 1968 hasta el año 2010, con el objetivo de reflejar sobre el rol que tiene hoy como “lugar de memoria” para el conjunto de la sociedad rosarina.
A contribuição da teoria das representações sociais para o estudo do patrimônio cultural – o exemplo da Ilha da Rita/SC
Authors: Cibele Dalina Piva Ferrari
Published: February 2022

A contribuição da teoria das representações sociais para o estudo do patrimônio cultural – o exemplo da Ilha da Rita/SC
Revelar o cenário, emprestar a paisagem: o trabalho in situ de Daniel Buren – 1967-1987
Authors: Tiago Machado de Jesus
Published: February 2022

Revelar o cenário, emprestar a paisagem: o trabalho in situ de Daniel Buren – 1967-1987
Uma janela aberta para a leitura de mundo: o desenho de crianças de 9/10 anos a partir de intervenções pedagógicas
Authors: Estela Maria Oliveira Bonci
Published: February 2022

Uma janela aberta para a leitura de mundo: o desenho de crianças de 9/10 anos a partir de intervenções pedagógicas
“Os museus podem contribuir para a dignidade da pessoa humana, para a dignidade social”
Authors: Maria Cristina Dias
Published: February 2022

Entrevista com Mário Chagas (Referência em museologia, o Prof. Dr. Mário Chagas realizou aula inaugural do Mestrado em Patrimônio Cultural e Sociedade na Univille em 2014, tematizando a relação entre museus e movimentos sociais na contemporaneidade)
Uma via em disputa: Rua do Príncipe, 1986 e 2004
Authors: João Abeid Filho  , Ilanil Coelho
Published: February 2022

O artigo analisa disputas travadas em processos de intervenção urbana tomando como referência de estudo a Rua do Príncipe, em Joinville, Santa Catarina. A pesquisa realizada focalizou dois projetos de intervenção que pretenderam articular a preservação do patrimônio cultural e que tiveram efeitos opostos. Diante disso, buscou-se compreender quais os fatores que têm orientado e que têm adquirido maior importância para a gestão pública do espaço urbano. A interpretação dos acontecimentos permitiu refletir sobre os usos sociais da rua, bem como sobre os propósitos que movem os projetos de intervenção em contextos diferenciados.
Turismo e direito como estratégias de preservação do patrimônio cultural arqueológico: o caso tapajônico
Authors: Anauene Dias Soares  , Filipe Vieira de Oliveira
Published: February 2022

Este artigo discute duas estratégias acerca da proteção do patrimônio cultural arqueológico brasileiro: o turismo, como fonte de acesso e valorização do patrimônio cultural, e o direito, com a efetividade normativa concernente a proteger o patrimônio cultural, por conta de seu valor quanto a memória e identidade de uma comunidade. Assim, a ausência de organização das atividades turísticas e as práticas ilícitas, como o tráfico ilícito e o comércio ilegal de bens culturais, podem ser consideradas algumas das responsáveis pela deterioração e dilapidação desses bens, como é observado com o patrimônio arqueológico tapajônico de Santarém – Pará. A pesquisa foi descritiva exploratória, identificando que a efetiva aplicação da legislação e a organização das atividades de visitação poderiam ser estratégias para a preservação e a manutenção do patrimônio cultural brasileiro, principalmente do arqueológico.
Tratamento cirúrgico de anquilose de articulação temporomandibular após trauma: relato de caso
Authors: Cristovão Marcondes de Castro Rodrigues  , Daniela Meneses Santos  , Mirlany Mendes Maciel Oliveira  , Matheus Silvestre Municci  , Claudia Jordão Silva  , Marcelo Caetano Parreira Silva
Published: February 2022

A anquilose de articulação temporomandibular (ATM) é uma alteração anatômica e funcional, podendo ter como principais agentes etiológicos o trauma ou a infecção. Seu tratamento representa um desafio no que diz respeito ao sucesso e à prevenção de recidiva. Atualmente, existem diversas modalidades de tratamento cujos objetivos são proporcionar maior qualidade de vida ao paciente e reestabelecer a funcionalidade do sistema estomatognático. Objetivo: Relatar o caso clínico de anquilose de ATM em decorrência de uma fratura de ossos da face. Relato de caso: Paciente do gênero masculino, 37 anos, vítima de queda da própria altura evoluindo com fratura bilateral de côndilo alta. Optou-se pelo tratamento conservador e por fratura de sínfise. Paciente não colaborou com o tratamento e retornou ao serviço sete anos após o trauma inicial apresentando diminuição de abertura bucal e dificuldade de higienização bucal, mastigação e socialização. Ao exame tomográfico, foi confirmado o diagnóstico de anquilose bilateral de ATM, e decidiu-se pela remoção cirúrgica do bloco anquilótico. Conclusão: A remoção cirúrgica da massa anquilótica da ATM representa um grande desafio em virtude da complexidade do tratamento, sendo de extrema importância um acompanhamento multiprofissional para a obtenção de sucesso no tratamento a longo prazo.
Perfil clínico-epidemiológico de pacientes internados com infecções odontogênicas
Authors: Caio César Gonçalves Silva  , Kalyne Kelly Gonçalves Negromonte  , Flávia Catarina da Silva Santos  , Ingrid Pereira de Miranda  , Mariane Ferreira Rodrigues de Melo  , Demóstenes Alves Diniz  , David Moraes de Oliveira
Published: February 2022

Infecções na cavidade oral possuem grande potencial para propagação, e sua proximidade com estruturas anatômicas importantes, como as vias aéreas e estruturas vasculares, torna imprescindível o controle rápido dessas afecções. Objetivo: Identificar o perfil clínico-epidemiológico dos pacientes diagnosticados com infecções odontogênicas internados em um hospital de nível terciário da cidade do Recife (PE). Materiais e métodos: Abordagem quantitativa, retrospectiva, no período de março de 2016 a dezembro de 2017, na enfermaria do setor de cirurgia e traumatologia bucomaxilofacial do Hospital da Restauração. A amostra contou com 81 participantes de 1 a 71 anos. A coleta dos dados deu[1]se por análise de prontuários. Entre as informações coletadas, estavam dados sociodemográficos e clínicos. Resultados: Viu-se alta prevalência de crianças (< 10 anos) acometidas, totalizando quase 30% dos casos, assim como maior representação do sexo masculino (55,6%). A cárie esteve presente em 76,8% dos casos como fator etiológico, e as manifestações clínicas mais comuns foram edema (98,8%), secreção (37%) e trismo (28,4%). O tratamento de escolha em 100% dos casos foi a antibioticoterapia, sendo o medicamento mais utilizado a ceftriaxona (58/81). Conclusão: Este estudo possibilitou identificar aspectos relacionados ao perfil clínico-epidemiológico dos pacientes internados com infecção odontogênica, destacando o papel fundamental de programas de atenção e cuidado da higiene oral.
Efeito da terapia fotodinâmica na desinfecção do sistema de canais radiculares
Authors: Dionatan Gomes  , Kallyane Navarrete Gonçalves de Andrade  , Larissa Nunes Rosa  , Carlla Sloane Alberton  , Flávia Sens Fagundes Tomazinho
Published: February 2022

A desinfecção dos canais radiculares é fundamental para o sucesso do tratamento endodôntico. Objetivo: Avaliar a eficácia antibacteriana da terapia fotodinâmica utilizando diferentes protocolos em canais radiculares infectados com Enterococcus faecalis. Material e métodos: Utilizaram-se 32 dentes humanos. Os canais foram contaminados com E. faecalis por 72 horas. Após esse período, eles foram preenchidos com uma solução de azul de metileno a 25 μg/mL até a sua embocadura, ativados com laser diodo de baixa potência e então divididos em quatro grupos experimentais (n = 8) de acordo com o protocolo de uso do laser: grupo I) ativado por 3 minutos em um comprimento de onda de 660 nm com 40 mW de potência total; grupo II) ativado por 5 minutos em um comprimento de onda de 660 nm com 40 mW de potência total; grupo III) 3 minutos em um comprimento de onda de 780 nm com 40 mW de potência total; grupo IV) 5 minutos em um comprimento de onda de 780 nm com 40 mW de potência total. As amostras bacteriológicas foram coletadas antes (A1) e depois (A2) do procedimento específico de cada grupo. O número de unidades formadoras de colônias foi contado. Resultados: Foi observada redução significativa no número de unidades formadoras de colônia. Houve diferença estatisticamente significante entre os grupos, e o protocolo do grupo II foi o que obteve maior diminuição do número de células viáveis após o uso da terapia fotodinâmica. Conclusão: Viu-se, com a metodologia empregada, que a terapia fotodinâmica leva à redução da contaminação intracanal, mas não foi capaz de erradicar completamente as bactérias contaminantes.
Prevalence of foramen of Huschke and petrotympanic fissure in the Brazilian population: CBCT study
Authors: Ana Luiza Esteves Carneiro  , Danielle Ayumi Nishimura  , Romualdo Monteiro de Barros  , Henrique Tuzzolo-Neto  , Jun Ho Kim  , Claudio Costa
Published: February 2022

The aim of the present study was to analyze cone-beam computed tomography (CBCT) images to study the prevalence of foramen of Huschke (FH) and petrotympanic fissure (PF) in a sample of the Brazilian population. Material and Methods: A total of 146 CBCT exams were studied (292 ears), being 100 women (68.5%) and 46 men (31.5%). The images were evaluated by a maxillofacial radiology specialist, who noted the presence of FH and stated if the PF could be clearly observed. Frequency and descriptive analyses were performed on dedicated software (SPSS 10.0; SPSS Inc., Chicago, IL). Results: FH was observed in 10 ears (6.8%) of nine patients (13.14%), eight patients (11.68%) presenting it unilaterally, and one patient (1.46%) bilaterally. PF was observed in 113 patients (77.39%), 35 (23.97%) of those presenting it unilaterally and 78 (53.42%) bilaterally, being observed in 192 ears (65.75%). Conclusion: FH is an anatomical anomaly with prevalence of 6.8% of the studied ears, while PF is an anatomical feature that was observed on 65.75% of the ears.
Hetero-Diels-Aider Reactions of 1-0xa-1,3-butadienes
Authors: Tietze L. F. , Kettschau G. , Gewert J. A. , Schuffenhauer A.
Published: February 2022

Many biologically active and widely distributed natural products contain a dihydro- or a tetrahydropyran moiety. One of the best methods for the synthesis of these compounds is the hetero Diels-Aider reaction of 1-0Xia-1,3-butadienes which leads to substituted and annulated 3,4-dihydro-2H-pyrans usually in excellent yields and high selectivity. Further transformations of these substances e.g. by hydrogenation yield the tetrahydropyrans with the basic skeleton of the carbohydrates.

In this article at first theoretical aspects of the cycloaddition are discussed which include ab initio calculations of the energies and the coefficients of 1-oxa-1,3-butadienes and different dienophiles. In addition, calculations of the transition structure of the cycloaddition of acrolein and ethene are presented. In the second chapter general considerations on the regia- and stereoselectivity of the cycloadditions are presented. In the following parts different hetero Diels-Aider reactions with activated and non-activated 1-oxa-1,3-butadiens and their use in diastereoselective transformations and the synthesis of natural products as carbohydrates, alkaloids, terpenes, steroids, cannabinoids, mycotoxins, ionophores and antibiotics are described. A point of emphasis is the domino Knoevenagel hetero Diels-Aider reaction in which the oxabutadienes are formed in situ and which allows the highly efficient synthesis of complex dihydropyrans starting from simple substrates. In the final chapters enantioselective cycloadditions, reactions on solid support and cycloadditions under high pressure are discussed.
Arginine Vasopressin, Synaptic Plasticity, and Brain Networks
Authors: Winklewski Pawel J. , Marcinkowska Anna B. , Biancardi Vinicia C.
Published: February 2022

The arginine vasopressin (AVP) neurohypophysial hormone is synthesized within specific central nervous system sites and axonally transported to multiple areas, acting as a neurotransmitter/neuromodulator. In this context, AVP acts primarily through vasopressin receptors A and B and is involved in regulating complex social cognition and behaviors and basic autonomic function. Many earlier studies have shown that AVP as a neuromodulator affects synaptic plasticity. This review updates our current understanding of the underlying molecular mechanisms by which AVP affects synaptic plasticity. Moreover, we discuss AVP modulatory effects on event-related potentials and blood oxygen level-dependent responses in specific brain structures and AVP effects on the network level oscillatory activity. We aimed at providing an overview of the AVP effects on the brain from synaptic to the network level.
The Role of Bupropion in the Treatment of Women with Sexual Desire
Disorder: A Systematic Review and Meta-Analysis
Authors: Sidi Hatta , Razali Nur Atikah , Choy Chia Lip , Roos Nur Aishah Che , Baharudin Azlin , Das Srijit
Published: February 2022

Although few clinical trials examined the efficacy of bupropion to treat sexual dysfunction
among female patients, a comprehensive and objective synthesis of the best available evidence
is still lacking. To date, to the best of our knowledge, there are no published systematic reviews or
meta-analyses specifically focusing on the role of bupropion in the treatment of female sexual dysfunction.
The main objective of the present study was to evaluate the efficacy of bupropion in the
treatment of female sexual dysfunction, and we hypothesized that bupropion is efficient in treating
female patients with sexual dysfunction. This review was conducted following the Preferred Reporting
Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A systematic search
for published literature was performed using Ovid, Medline, Scopus, Cochrane Library, Science Direct,
and PubMed databases. In our study, we found that bupropion was almost three-fold more favorable
in improving problems with sexual desire (pool estimate 2.845, 95% CI: 0.215 to 5.475, I2=
95.6%, p=0.034). A meta-regression was performed to explore heterogeneity and we found that only
the dosage of bupropion was statistically significant in explaining the variance, i.e., the lower the
dosage (150 mg vs. 300 mg), the better the improvement in the sexual desire of women with hypoactive
sexual desire disorder (HSDD). Based on the results of this systematic review and metaanalysis,
there is a potential role of bupropion as an effective treatment for women with HSDD.
An Update on Nondopaminergic Treatments for Motor and Non-motor
Symptoms of Parkinson’s Disease
Authors: Jing Xiao-Zhong , Yuan Xiang-Zhen , Luo Xingguang , Zhang Shu-Yun , Wang Xiao-Ping
Published: February 2022

Nondopaminergic neurotransmitters such as adenosine, norepinephrine, serotonin, glutamate,
and acetylcholine are all involved in Parkinson's disease (PD) and promote its symptoms.
Therefore, nondopaminergic receptors are key targets for developing novel preparations for the
management of motor and non-motor symptoms in PD, without the potential adverse events of dopamine
replacement therapy. We reviewed English-written articles and ongoing clinical trials of
nondopaminergic treatments for PD patients till 2014 to summarize the recent findings on nondopaminergic
preparations for the treatment of PD patients. The most promising research area of nondopaminergic
targets is to reduce motor complications caused by traditional dopamine replacement
therapy, including motor fluctuations and levodopa-induced dyskinesia. Istradefylline, Safinamide,
and Zonisamide were licensed for the management of motor fluctuations in PD patients, while novel
serotonergic and glutamatergic agents to improve motor fluctuations are still under research. Sustained-
release agents of Amantadine were approved for treating levodopa induced dyskinesia (LID),
and serotonin 5HT1B receptor agonist also showed clinical benefits to LID. Nondopaminergic targets
were also being explored for the treatment of non-motor symptoms of PD. Pimavanserin was approved
globally for the management of hallucinations and delusions related to PD psychosis.
Istradefylline revealed beneficial effect on daytime sleepiness, apathy, depression, and lower urinary
tract symptoms in PD subjects. Droxidopa may benefit orthostatic hypotension in PD patients.
Safinamide and Zonisamide also showed clinical efficacy on certain non-motor symptoms of PD patients.
Nondopaminergic drugs are not expected to replace dopaminergic strategies, but further development
of these drugs may lead to new approaches with positive clinical implications.
K-means clustering for classifying the quality management of secondary education in Indonesia
Authors: Mustakim Zaenal , Kamal Rahmat
Published: February 2022

Mapping educational management is critical for improving national education quality. This study aims to classify Indonesian provinces in terms of secondary education management within quality standard parameters. Framed in a quantitative approach with the K-means cluster analysis, this study applied eleven parameters to classify the provinces into three main clusters. These parameters were schools, new entrants, students, repeaters, drop-outs, graduates, teachers, classrooms, laboratories, libraries, and school health services. Secondary data related to secondary education in Indonesia published by the Ministry of Education and Culture were analyzed. With the R software, the clusters were formed based on the shared characteristics of the provinces. This study found that Cluster 1 had twenty-two provinces, Cluster 2 two provinces, and Cluster 3 ten provinces. Cluster 2 was found to be the best cluster, while West Java and East Java shared similar characteristics, hence in the same cluster. Further, 5.88% of the provinces were eligible to be pilot models for the standard quality management of education in Indonesia. There is, therefore, a pressing need for the improvement of education infrastructure to support a better-quality education.