bluuebunny/crossref_metadata_2025 huggingface dataset:
СТРУКТУРА РОСЛИННИХ ЕКСПОЗИЦІЙ КРЕМЕНЕЦЬКОГО БОТАНІЧНОГО САДУ
Authors: Lisnichuk A. M. , Hutsalo N. B.
Published: March 2021

The findings of the systematic analysis of Kremenets Botanical Garden displays are given. For the purpose of maintaining, optimizing and arranging plant compositions, the ecological and biomorphological features of species have been clarified.
The flora of botanical expositions includes 272 species of 3 divisions, 5 classes, 66 families, 138 genera. The systematic analysis demonstrated a numerous representation of the Magnoliophyta division by the number of families (56, 84.9 %), genera (120, 87.6 %) and species (205, 75.4 %), of which Magnoliópsida contains 172 species (63.2 %), with Liliopsida containing 33 species (12.1 %). The Pinophyta division is represented by 6 families, 13 genera, and 62 species (22.8 %). The Polypodiophyta division has smaller numbers – 4 families, 4 genera, and 5 species (1.8 %). According to Ch. C. Raunkiær’s classification, decorative cultures are present in 5 life forms. The Phanerophytes play a significant role in the expositions’ design; their percentage is 48.1 % (131 species). According to the classification of I. G. Serebriakov in the structure of display there are 8 types, which are dominated by herbaceous plants (89 species, 32.7 %). According to ecological indicators, 5 types of ecomorphs have been identified: the heliomorph, the hygromorph, the thermomorph, the acidomorph, and the tropomorph. Among them heliophytes (165 species, 60.7 %), mesophytes (97 species, 35.7 %), microthermophytes (265 species, 97.4 %), subacidophiles (96 species, 35.3 %), and mesotrophs (230 species, 84.5 %) are dominant. It is established that the displays on the territory of the Botanical Garden are stable cultural phytocenoses (or close to that), which function in specific conditions. For the purpose of optimizing botanical expositions, it is advisable to expand the range of ornamental plants.
ОЦІНКА БІОЛОГІЧНОЇ ДІЇ ЕЛЕМЕНТВМІСНИХ ЛІПІДНИХ КОМПЛЕКСІВ З CHLORELLA VULGARIS НА ФУНКЦІОНАЛЬНИЙ СТАН ЗДОРОВИХ ЩУРІВ
Authors: Bodnar O. I. , Kovalska H. B. , Lukashiv O. Ya. , Grubinko V. V.
Published: March 2021

Chlorella is one of the most promising species of algae, which is widely cultivated for the industrial production of nutraceuticals in the form of tablets or powder. The value of Chlorella is primarily due to the high content of proteins and lipids (51–58 % and 20–23 % of dry weight respectively), carotenoids and an almost complete set of vitamins. At the same time, in the process of cultivation, a method was developed to enrich algobiomass and its individual components (primarily the lipid fraction) with selenium, zinc, chromium, as important regulatory trace elements.

From chlorella, we obtained seleniumlipid, selenium-zinclipid and selenium-chromiumlipid complexes, and their constancy and structure were grounded by chromatographic and mass spectrometric analysis. After feeding healthy rats with a starch solution of selenium-zinclipid complex (1 ml of which contained 0.4 μg of selenium, 2.5 μg of zinc and 0.5 mg of lipids) and selenium-chromiumlipid complex (1 ml contained 1.85 μg of selenium, 1.1 μg of chromium, 0,45 mg of lipids), no signs of intoxication were found (total medium molecular peptides content was reduced to 1.5 times, the content of TBA-active products and diene conjugates were also decreased), antioxidant processes (increase of glutathione content and activity of glutathione peroxidase while reducing the functional role of catalase) were activated (by increasing of succinate dehydrogenase and cytochrome oxidase activity, glutamate dehydrogenase - the way of glutamate formation), which contributed to the successful functioning of the antioxidant system and maintenance of energy and metabolic homeostasis in the body.

The obtained results enable the use of biologically active additives from chlorella, enriched with trace elements Se (IV), Zn (II) and Cr (III), as promising therapeutic and prophylactic substances, which will contribute to the successful functioning of the antioxidant system, maintain energy metabolism and metabolism correction of pathological processes, which is the basis for further studies of the biological activity of the complexes under study.
MEASURING METHODOLOGY AND PARAMETRIC TESTS OF ROTARY POSITIONING TABLE
Authors: Tuleja Peter
Published: March 2021

Urgency of the research. The use of positioning tables as peripheral devices for production or robotic technology is an urgent need for today's automated operations. Since their task is to extend the user's possibilities in the workplace, their design and
control method and, last but not least, the technical parameters must correspond to the level of machine tools and robots. Target setting. The aim of this paper was to approach in a real case the methodical approach to the determination of key parameters of rotary positioning units intended for manufacturing technology and robotics. The tests carried out on the real representative gave an answer to the question of the applicability of the selected methodology for measuring selected parameters of the rotary uniaxial positioning table. Actual scientific researches and issues analysis. Research in this area consisted in designing a methodological basis for obtaining relevant data useful for evaluating the technical level of the prototype being measured. Uninvestigated parts of general matters defining. In the paper and basically also in the performance of the tests on the VAPOS module it was not possible to perform full parametric tests for some problems related to the technical design of the sample (prototype), therefore the proposed measurement methodology focused rather on the issue of making and justifying the use of some building elements of the table. The research objective. The aim of the project and the article was to verify the validity of the methodology used and to
verify the suitability of the type of reducer used in such a technique. The statement of basic materials. The basic materials for the creation of the article were processed data from sample measurement at our department. Some of the data contained in the measurement protocol was not difficult to disclose because it is the know-how of the department and the sponsor. Conclusions. The conclusions of the paper and the project show the suitability of the chosen methodology and the results from measurements according to this methodology were used for further improvement of the design of the rotary table at the manufacturer and in the development of new types of reducers of their supplier.
ДИНАМІЧНИЙ АНАЛІЗ ПОСЛІДОВНОСТЕЙ API-ВИКЛИКІВ ОС ANDROID
Authors: Kazymyr Volodymyr , Karpachev Igor , Sipakov Vladyslav
Published: March 2021

Актуальність теми дослідження. На сьогодні набуло значного поширення використання користувачами мобільних пристроїв та додатків з метою зберігання приватної та конфіденційної інформації. Поряд з цим, існують методи та шляхи поширення шкідливого програмного забезпечення (ПЗ) в операційній системі (ОС) Android. Для ефективної боротьби з ними постає необхідність розробки нових покращених підходів до виявлення шкідливого ПЗ в OС Android. У статті розглянуто новий метод динамічного аналізу додатків, який дозволить покращити існуючу систему безпеки. Постановка проблеми. У галузі забезпечення ефективної та безпечної роботи мобільних пристроїв функціональна та інформаційна безпека розглядаються як дві фундаментальні складові, що взаємодоповнюють одна одну. Одним із найефективніших способів отримання зловмисником доступу до конфіденційної інформації є використання ОС Android. Одним із засобів підвищення надійності роботи є розробка моделей безперервного динамічного захисту. Аналіз останніх досліджень і публікацій. Розглянуто останні публікації у відкритому доступі, включаючи дані Google Malware Project, PScout Android Permissions Mappings та Axplorer Permissions Mappings та роботу Android
Malware Detection Using Permission Analysis. Виділення недосліджених частин загальної проблеми. Розробка та математичне обґрунтування моделей безперервного аналізу API-викликів в ОС Android. Постановка завдання. Запропонувати базову модель захисту ОС Android, що ґрунтується на аналізі послідовностей API-викликів. Виклад основного матеріалу. У статті наведено метод отримання та аналіз послідовностей API-викликів OС Android за допомогою інструментарію Frida. Також наведено найбільш репрезентативні результати тестування запропонованого методу. Висновки відповідно до статті. Запропоновано метод динамічного аналізу шкідливого ПЗ з використанням інструментарію для реверс-інжинірингу Android та IOS додатків – Frida. Запропонований метод динамічного аналізу API-викликів можна використовувати для покращення існуючих систем аналізу APK, а метод дослідження вірусних послідовностей можна поширити для всіх характерних вірусних груп.
Qualidade de vida de pacientes em tratamento com anticoagulante oral
Authors: De Araújo Hirla Vanessa Soares , Meira Andreza do Carmo de Albuquerque Pôrto , Bem Paulo Henrique do Nascimento , Dos Anjos Rita de Cássia Cordeiro Bastos Leite , Belo Rebeka Maria de Oliveira , Bezerra Simone Maria Muniz da Silva , De Saturno Maria Regina Silva
Published: March 2021

Objetivo: Avaliar a qualidade de vida de pacientes que fazem uso de anticoagulante oral. Métodos: Estudo descritivo, transversal, com abordagem quantitativa, realizado no ambulatório egresso de anticoagulante oral de um hospital de referência. A amostra foi de 93 pacientes. Foi utilizado questionário semiestruturado, abordando variáveis socioeconômicas e clínicas e o instrumento Duke Anticoagulation Satisfaction Scale (DASS). Resultados: Houve predominância do sexo feminino (51; 54,4%), com idade média de 51,25 ±12,10 anos. A principal indicação de anticoagulante oral foi a troca de válvula cardíaca (46; 49,5%) seguida da fibrilação atrial (18; 19%). Na avaliação da qualidade de vida, no domínio total o resultado encontrado foi de 79,0± 21,6 indicando que estes usuários apresentam pior qualidade de vida quando comparados com a literatura. Conclusão: Este estudo demonstrou que os pacientes apresentaram baixa qualidade de vida. Observou-se que quanto maior a idade do indivíduo, menor o escore DASS e melhor qualidade de vida. As comorbidades associadas são fatores que contribuem para uma pior avaliação.
Assistência a saúde prestada a hipertensos e diabéticos no Brasil: revisão integrativa
Authors: Ferreira Fábio da Costa , Silva Marcos Valério Santos da
Published: March 2021

Objetivo: Analisar as evidências disponíveis na literatura cientifica sobre a assistência à saúde prestada aos usuários hipertensos e diabéticos no Brasil. Métodos: Trata-se de estudo de revisão integrativa das bases de dados Scientific Eletronic Library Online (Scielo), Literatura Latino-Americana e do Caribe (LILACS) e Base de Dados em Enfermagem (BDENF), utilizando-se descritores de acordo com os Descritores em Ciências da Saúde (DeCS) e combinando-os por meio do uso do operador booleano AND, critérios de inclusão: publicações de 2009 a 2018 em português, espanho e inglês, sendo excluídos os duplicados e aqueles que não aboradaram a temática. Resultados: Foram selecionados nove estudos para analise, os quais abordaram a temática proposta pelo atual estudo, logo emergiram dois principais grupos temáticos: Estrutura das unidades de saúde e Processos de atendimentos. Tendo os mesmos impactos relevantes sobre a assistencia prestadas aos usuários hipertensos e diabéticos. Considerações finais: Como limitação destaca-se a inclusão de inúmeros estudos com diferentes delineamentos de pesquisa dificultando a analise, quanto potencialidade tem a amostragem dos estudos selecionados, pois proporcionou um efetivo entendimento da qualidade da assitencia prestada aos hipertensos e diabéticos no Brasil. Além disso, os achados subsidiarão a atuação de gestores e profissionais de saúde.
Avaliação da saúde bucal de pacientes portadores de diabetes mellitus tipo II atendidos em uma Unidade Básica de Saúde no Estado do Amazonas
Authors: Sarmento Maria das Graças Silva , Da Silva Michelli Domingos , Crainey James Lee
Published: March 2021

Objetivo: Este relato de experiência tem o objetivo de avaliar e descrever a luz da literatura sobre a saúde bucal dos pacientes portadores de diabetes mellitus tipo II atendidos na Unidade Básica de Saúde no Estado do Amazonas. Relato de experiência:  Trata-se de um estudo descritivo, do tipo relato de experiência, acerca do período em atendimento de saúde bucal em portadores de diabetes mellitus, em uma unidade básica de saúde no Estado do Amazonas no período de janeiro a dezembro de 2019.  Foi vivenciado que existe um alto índice de pessoas com dentes permanentes cariados, perdidos e obturados (CPOD), diabéticos através do atendimento especializado na UBS. A UBS conta hoje com equipes de saúde especializadas, e visa controlar a glicemia do paciente durante o tratamento odontológico. Os auxiliares de saúde bucal e os odontólogos, podem contribuir para melhora da qualidade de vida desses pacientes, ficando responsável pela realização de uma boa higiene oral. Considerações finais: Com relação as condições de saúde bucal, foi confirmado um auto índice de diabéticos que possui o índice de dentes cariados e obturados mais elevado, necessita de maior intervenção periodontal e classicamente evidenciou-se maiores problemas periodontias neste grupo.
BiasNet: A model to predict ligand bias towards GPCR signaling
Authors: Sanchez Jason , KC Govinda , Franco Julian , Garcia Jesus , sirimulla suman
Published: March 2021

Signaling bias is a feature of many G–protein coupled receptor (GPCR) modulating drugs with clinical implications. Whether it is therapeutically advantageous for a drug to be G Protein biased or β-Arrestin (β-Arr) biased, depends on the context of the signaling pathway. Here, we explored GPCR ligands that exhibit biased signaling to gain insights into scaffolds and pharmacophores that leads to bias. More specifically, we used BiasDB, a database containing information about GPCR biased ligands and all ligands which show a (β-Arr) / G protein bias or a G protein / β-Arr bias are considered for the study. Four machine learning models were trained on these ligands to classify them. The features which were most important for training the models were analyzed. Two of these features (number of secondary amines and number of aromatic amines) were more prevalent in β-Arr biased ligands. After training a Random Forest model on HierS scaffolds, we found five scaffolds which demonstrated G protein or β-Arr bias. We also conducted t-SNE clustering, observing correspondence between unsupervised and supervised machine learning methods. To increase the applicability of our work, we developed a web implementation of our models which can predict bias based on a user-provided SMILES patterns. Our web implementation is available at: drugdiscovery.utep.edu/biasnet.
Origins of Clustering of Metalate-Extractant Complexes in Liquid-Liquid Extraction
Authors: Nayak Srikanth , Kumal Raju R. , Liu Zhu , Qiao Baofu , Clark Aurora , Uysal Ahmet
Published: March 2021

Effective and energy efficient separation of precious and rare metals is very important for a variety of advanced technologies. Liquid-liquid extraction (LLE) is a relatively less energy intensive separation technique, widely used in separation of lanthanides, actinides, and platinum group metals (PGMs). In LLE, the distribution of an ion between an aqueous phase and an organic phase is determined by enthalpic (coordination interactions) and entropic (fluid reorganization) contributions. The molecular scale details of these contributions are not well understood. Preferential extraction of an ion from the aqueous phase is usually correlated with the resulting fluid organization in the organic phase, as the longer-range organization increases with metal loading. However, it is difficult to determine the extent to which organic phase fluid organization causes, or is caused by, metal loading. In this study, we demonstrate that two systems with the same metal loading may impart very different organic phase organization; and investigate the underlying molecular scale mechanism. Small angle X-ray scattering shows that the structure of a quaternary ammonium extractant solution in toluene is affected differently by the extraction of two metalates (octahedral PtCl62- and square-planar PdCl42-), although both are completely transferred into the organic phase. The aggregates formed by the metalate-extractant complexes (approximated as reverse micelles) exhibit more long-range order (clustering) with PtCl62- compared to that with PdCl42-. Vibrational sum frequency generation spectroscopy, and complimentary atomistic molecular dynamics simulations on model Langmuir monolayers, indicate that the two metalates affect the interfacial hydration structures differently. Further, the interfacial hydration is correlated with water extraction into the organic phase. These results support a strong relationship between the organic phase organizational structure and different local hydration present within the aggregates of metalate-extractant complexes, which is independent of metalate concentration.
Controlled Surface Reconstruction on Ferromagnetic Oxides: Spin Pinning Effect to the Oxyhydroxide Layer and Its Enhanced Oxygen Evolution Activity
Authors: Wu Tianze , Ren Xiao , Sun Yuanmiao , Sun Shengnan , Xian Guoyu , Scherer Günther G. , Fisher Adrian C. , Mandler Daniel , Ager Joel , Grimaud Alexis , Wang Junling , Sheng Chengmin , Yang Haitao , Gracia Jose , Gao Hong-jun , Xu Zhichuan J.
Published: March 2021

The production of hydrogen by water electrolysis suffers from the kinetic barriers in the oxygen evolution reaction (OER) that limits the overall efficiency. As spin-dependent kinetics exist in OER, the spin alignment in active OER catalysts is critical for reducing the kinetic barriers in OER. It is effective to facilitate the spin polarization in ferromagnetic catalysts by applying external magnetic field, which increases the OER efficiency. However, more active OER catalysts tend to have dynamic open-shell orbital configurations with disordered magnetic moments, without showing an apparent long-range interatomic ferromagnetism; thus controlling the spin alignment of these active catalysts is challenging. In this work, we report a strategy with spin pinning effect to make the spins in active oxyhydroxides more aligned for higher intrinsic OER activity. Such strategy bases on a controllable reconstruction: ferromagnetic oxides with controlled sulfurization can evolve into stable oxideFM/oxyhydroxide configurations with a thin oxyhydroxide layer under operando condition. The spin pinning effect is found at the interface of oxideFM/oxyhydroxide. The spin pinning effect can promote spin selective electron transfer on OER intermediates to generate oxygens with parallel spin alignment, which facilitates the production of triplet oxygen and increases the intrinsic activity of oxyhydroxide by ~ 1 order of magnitude. Under spin pinning, the spins in oxyhydroxide can become more aligned after magnetization as long-range ferromagnetic ordering is established on the magnetic domains in oxideFM. The OER kinetics are facilitated accordingly after magnetization, implying that the spin pinning effect is involved in the rate-determining step and this step is spin dependent. The spin polarization process in OER under spin pinning is also believed to be sensitive to the existence of active oxygen ligand (O(-)) in oxyhydroxide. When the O(-) is created in 1st deprotonation step under high pH, the spin polarization of ligand oxygens will be facilitated, which reduces the barrier for subsequent O-O coupling and promotes the O2 turnover.
Temperature-Dependent Solid-State NMR Proton Chemical-Shift Values and Hydrogen Bonding
Authors: Malär Alexander A. , Völker Laura A. , Cadalbert Riccardo , Lecoq Lauriane , Ernst Matthias , Böckmann Anja , Meier Beat H. , Wiegand Thomas
Published: March 2021

Temperature-dependent NMR experiments are often complicated by rather long magnetic-field equilibration times, for example occurring upon a change of sample temperature. We demonstrate that the fast temporal stabilization of the magnetic field can be achieved by actively stabilizing the temperature which allows to quantify the weak temperature dependence of the proton chemical shift which can be diagnostic for the presence of hydrogen bonds. Hydrogen bonding plays a central role in molecular recognition events from both fields, chemistry and biology. Their direct detection by standard structure determination techniques, such as X-ray crystallography or cryo-electron microscopy, remains challenging due to the difficulties of approaching the required resolution, on the order of 1 Å. We herein explore a spectroscopic approach using solid-state NMR to identify protons engaged in hydrogen bonds and explore the measurement of proton chemical-shift temperature coefficients. Using the examples of a phosphorylated amino acid and the protein ubiquitin, we show that fast Magic-Angle Spinning (MAS) experiments at 100 kHz yield sufficient resolution in proton-detected spectra to quantify the rather small chemical-shift changes upon temperature variations.
Rotaxane CoII Complexes as Field-Induced Single-Ion Magnets
Authors: Cirulli Martina , Salvadori Enrico , Zhang Zhi-Hui , Dommett Michael , Tuna Floriana , Bamberger Heiko , Lewis James , Kaur Amanpreet , Tizzard Graham , van Slageren Joris , Crespo Otero Rachel , Goldup Stephen , Roessler Maxie
Published: March 2021

Mechanically chelating ligands have untapped potential for the engineering of metal ion properties by providing reliable control of the number, nature and geometry of donor atoms, akin to how a protein cavity controls the properties of bound metal ions. Here we demonstrate this principle in the context of CoII-based single-ion magnets. Using multi-frequency EPR, susceptibility and magnetization measurements we found that these complexes show some of the highest zero field splittings reported for five-coordinate CoII complexes to date. The predictable coordination behavior of the interlocked ligands allowed the magnetic properties of their CoII complexes to be evaluated computationally a priori and our combined experimental and theoretical approach enabled us to rationalize the observed trends. The predictable magnetic behavior of the rotaxane CoII complexes demonstrates that interlocked ligands offer a new strategy to design metal complexes with interesting functionality.
Promotion and Tuning of the Electrochemical Reduction of Hetero- and Homobimetallic Zinc Complexes
Authors: Kelsey Shaun , Kumar Amit , Oliver Allen G. , Day Victor W. , Blakemore James
Published: March 2021

Compounds containing multiple metals attract significant interest due to the useful redox and reactivity properties of such species. Here, the electrochemical properties of a family of macrocyclic complexes that feature a zinc(II) center paired with a second redox-inactive metal cation in heterobimetallic (Na+, Ca2+, Nd3+, Y3+) motifs or a homobimetallic (Zn2+) motif have been investigated. The new complexes were prepared via a divergent strategy, isolated, and structurally characterized by single-crystal X-ray diffraction (XRD) analysis. XRD results show that the structure of the complexes is modulated by the identity of the incorporated secondary metal ions. Cyclic voltammetry data reveal that ligand-centered reduction is promoted in the bimetallic complexes and that the paired metal ions synergistically influence the redox properties of the complexes. Similar to prior work from our group and others, the bimetallic complexes containing stronger Lewis acids undergo more significant reduction potential shifts; contrasting with prior work on complexes containing redox-active metals, however, the zinc(II) complexes studied here display faster electron transfer (as judged by lower reorganization energies, λ) when incorporating di- or tri-valent Lewis acids in contrast to monovalent (and more weakly acidic) sodium. The quantified trends in these data offer insights that help distinguish metal- versus ligand-centered reduction of bimetallic complexes.
A Potential–dependent Thiele Modulus to Quantify the Effectiveness of Porous Electrocatalysts
Authors: Wan Charles , Greco Katharine , Alazmi Amira , Darling Robert , Chiang Yet- Ming , Brushett Fikile
Published: March 2021

Electrochemical reactors often employ high surface area electrocatalysts to accelerate volumetric reaction rates and increase productivity. While electrocatalysts can alleviate kinetic overpotentials, diffusional resistances at the pore-scale often prevent full catalyst utilization. The effect of intraparticle diffusion on the overall reaction rate can be quantified through an effectiveness factor expression governed by the Thiele modulus parameter. This analytical approach is integral to the development of catalytic structures for thermochemical processes and can be extended to electrochemical processes provided the relationship between reaction kinetics and electrode overpotential is incorporated. Here, we derive a potential-dependent Thiele modulus to quantify the effectiveness factor for porous electrocatalytic structures. We apply this mathematical framework to spherical microparticles as a function of applied overpotential across catalyst properties and reactant characteristics. The relative effects of kinetics and mass transport are related to overall reaction rates, revealing markedly lower catalyst utilization at increasing overpotential. Subsequently, we generalize the analysis to alternative catalyst shapes and provide guidance on the design of porous catalytic materials for use in electrochemical reactors.
Machine Learning Designs Non-Hemolytic Antimicrobial Peptides
Authors: Capecchi Alice , Cai Xingguang , Personne Hippolyte , Köhler Thilo , van Delden Christian , Reymond Jean-Louis
Published: March 2021

Machine learning (ML) consists in the recognition of patterns from training data and offers the opportunity to exploit large structure-activity database sets for drug design. In the area of peptide drugs, ML is mostly being tested to design antimicrobial peptides (AMPs), a class of biomolecules potentially useful to fight multidrug resistant bacteria. ML models have successfully identified membrane disruptive amphiphilic AMPs, however without addressing the associated toxicity to human red blood cells. Here we trained recurrent neural networks (RNN) with data from DBAASP (Database of Antimicrobial Activity and Structure of Peptides) to design short non-hemolytic AMPs. Synthesis and testing of 28 generated peptides, each at least 5 mutations away from training data, allowed us to identify eight new non-hemolytic AMPs against Pseudomonas aeruginosa, Acinetobacter baumannii, and methicillin resistant Staphylococcus aureus (MRSA). These results show that machine learning (ML) can be used to design new non-hemolytic AMPs.
Effects of COVID-19 on Sexual and Reproductive health
Authors: Shazia Mohammad  , Neema Acharya  , Kiran Borkar  , Shirin Mohammad
Published: March 2021

The outbreak of novel coronavirus disease was first reported in China in December 2019, and WHO declared the coronavirus pandemic on 11 March 2020. Since then, all the continents have observed a fast-growing upward trend in number of confirmed cases. During the epidemics, Sexual and reproductive health (SRH) and rights became a monumentous public health issue. The novel coronavirus (SARS-CoV-2) is new to humans and there is only some experimental data available to describe the sexual and reproductive health (SRH) effects of COVID-19 disease, including clinical appearance and consequences of COVID-19 infection during birth, or for people with STI (sexually transmitted infections) or HIV-related immunosuppression. We should not neglect the bearings at the level of the health system and delays or interludes in the routine availability of SRH facilities outside the therapeutic reach of SRH, such as pre-and postnatal tests, safe abortion, contraception, HIV/AIDS, and sexually transmitted infections. In addition, other factors warrant consideration, such as the possible rise in gender-based violence and domestic abuse and the consequences of COVID-19-related stigma and prejudice and their effect on SRH customers and health care providers. Therefore, the research community has an immediate requirement for the creation of all-inclusive clinical, epidemiological, and psycho-social behavioral ties between COVID-19 and SRH and the effects of rights. A comprehensive systematic literature search of the databases of PubMed, Web of Science, Embase, Medline, Cochrane and MedRxiv, was carried out.
The Effect of Topical Dapsone In Comparison With Tacrolimus On Dncb Induced Atopic Dermatitis In Mice
Authors: Aws D. Yousif  , Ahmed R. Abu-Raghif
Published: March 2021

To assess the effect of topical dapsone in the treatment of atopic dermatitis in comparison with tacrolimus.  A case-control study was done on 80 male Albino mice (20-30g) recruited from local markets, were treated with 1-Chloro-2,4-dinitrobenzene (DNCB)-induced atopic dermatitis and compared with age and the sex-matched control group comprised of 20 healthy male Albino mice. The topical applications of Tacrolimus 0.1% ointment and Dapsone 5% gel were performed on atopic dermatitis area for seven days and fourteen days once daily starting from the fourth day of induction and Complete blood count, IL-4 and IL-13 were measured in skin tissue homogenate in addition to histopathological evaluation of atopic dermatitis skin lesion and assessment of observational severity score and compared with those of controls. The results revealed that the levels of IL-4 and IL-13, total WBC, observational severity score, and the score of all histopathological markers were increased significantly in the group of mice treated with 1-Chloro-2,4-dinitrobenzene (DNCB) for A.D. induction in comparison with controls. These markers were reduced significantly after the topical application of tacrolimus. They showed a comparable reduction but after a longer duration of topical treatment with dapsone after two weeks of treatment. Topical application of dapsone on induced A.D. mice showed a significant reduction in the levels of IL-4 and IL-13, total WBC, observational severity score, and histopathological markers score and these effects were compared to those of topical tacrolimus.
Prevalence of Hypertension among Dental Patients with Diabetes Mellitus: An Institutional Study
Authors: Santhosh Kumar M P  , Arthi Balasubramaniam  , Sushanthi Suresh  , Indumathy Pandiyan
Published: March 2021

Diabetes mellitus and hypertension co-exists in many individuals as the pathogenic relationship between diabetes mellitus and hypertension is actually bidirectional. Extraction of teeth is a common procedure performed in Dentistry and the Co-existence of these systemic diseases in dental patients can cause many complications like delayed wound healing, infection or bleeding during dental extractions. The aim of the present study was to assess the prevalence of hypertension among dental patients with diabetes mellitus in south Indian population. A retrospective study was conducted from the data of 6682 dental patients who visited the outpatient Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, Chennai, for dental extractions due to various reasons during the time period from June 2019 – to March 2020. Patients data was retrieved from the institutional digital data registry and statistically analysed. Among 6682 patients who underwent extractions, 904 [13.5%] patients had diabetes mellitus. Among 904 patients with diabetes mellitus, 419 [46.3%] patients had hypertension. Prevalence of hypertension was more in males than females and the results were statistically not significant [p=0.062, (>0.05)]. Prevalence of hypertension was more in 41-50 years age group and the results were statistically significant. [p<0.001, (<0.05)]. According to our study, a high proportion of patients with diabetes mellitus undergoing dental extractions had hypertension which can cause increased morbidity and mortality. Males and patients belonging to fifth decade of life were more affected by both diabetes mellitus and hypertension.
Assessment of phytochemicals and quantification of primary and secondary metabolites of Artabotrys hexapetalus (L.f.) Bhandari leaves
Authors: Kousalya P  , Doss VA
Published: March 2021

The main goal of the research was to explore the existence of phytochemicals, quantification of primary and secondary metabolites of leaves extract of Artabotrys hexapetalus  (L.f.) Bhandari. The phytochemical activity of leaves of Artabotrys hexapetalus was assessed using different solvent extracts like water, ethanol, acetone, chloroform and petroleum ether. Among the different solvent extracts, aqueous leaves extract revealed the high content of phytochemicals. So the aqueous leaves extract was used for further investigations. Aqueous leaves extract of Artabotrys hexapetalus was subjected to quantitative analysis of primary metabolites like carbohydrates, proteins and amino acids. Quantitative analysis of secondary metabolites like flavonoids, tannins and phenols were performed using aqueous leaves extract of Artabotrys hexapetalus. Qualitative screening of phytochemicals reported the existence of carbohydrates, amino acids, proteins, flavonoids, alkaloids, saponins, phenols, glycosides, tannins and diterpenes. Quantitative analysis showed the presence of carbohydrates (43.16±1.0 mg/g extract), proteins (60.4±0.88 mg/g extract), amino acids (19.33 ± 1.30 mg/g extract), flavonoids (28.3 ±0.91 mg/g extract), tannins (24.53±1.02 mg/g extract) and phenols (7.63±0.85 mg/g extract). The present study concluded that aqueous leaves extract of Artabotrys hexapetalus as a potential source of phytochemicals, primary and secondary metabolites.
Boon and bane of various Intracanal medicaments in modern endodontics - A review
Authors: Arjun Hegde  , Ganaraj Shetty  , Akshatha G. Kamath
Published: March 2021

Eradication of the micro-organisms from the root canal is one of the prime concerns for endodontic treatment. This procedure can fail because of the survival of resistant micro-organisms in the dentinal tubules. Non-toxic Intracanal medicaments can destroy bacteria, reduce inflammation, and stimulate hard tissue formation, which can be useful in achieving the success of root canal treatment after the accomplishment of chemo-mechanical preparation. Comprehensive research is essential to identify a suitable intracanal medicament. Therefore, this article aims to give a brief review to the clinicians about the most common Intracanal Medicaments in use that have evolved from the time of inception until the recent years which can be used during the root canal therapy that would fulfil their need & requirement.
Assessment of Medication Adherence Among Diabetic Mellitus Patients in a Tertiary Care Hospital
Authors: Kaavya S  , Srinivasan V
Published: March 2021

Diabetic Mellitus is a commonly known disease referred to as diabetics, needs to follow medication consistently without a break to keep the blood sugar level in control. Consistent medication deals with a measure of how patients adhere to their medications and is done by health care providers. This is very important because it ensures that the patient follows the doctors order correctly and also ensure that the treatment is not just based on a therapeutic contract between doctor and patient. This monitoring is very high, with patients having serious problems with diabetics and is reported low for chronic patients. The aim of this study is to assess medication adherence in type 2 diabetes patients. The study was carried out at Saveetha Medical College. Data was collected using a standardized questionnaire. Data entered in MS Excel and analyzed using Weka 3.8.3 and results interpreted. The best way health professionals can tackle the adherence problem is through quality patient counselling, as done in this study.
Implementasi Electronic Data Processing Pada Koperasi Wanita
Authors: Mutiarni Rita
Published: March 2021

Penelitian yang dilakukan pada Koperasi Wanita di Jombang ini bertujuan untukMengetahui sebaran Koperasi di Jombang yang menyelenggarakan pencatatan transaksi secara komputerisasi (Electronic Data Processing), mengetahui penerapan unsur-unsur Electronic Data Processing dan Faktor Pendukung Kesuksesan Pelaksanaan Electronic Data Processing di Koperasi Wanita kabupaten Jombang, Mengetahui apakah variabel EDP dan Faktor Pendukung Kesuksesan  Pelaksanaan  Electronic  Data Processing berpengaruh terhadap keputusan manajemen Koperasi. Jenis penelitian adalah penelitian kualitatif, dengan melibatkan 19 responden sebagai sampel penelitian. Dari hasil penelitian diketahui bahwa Dari 306 Koperasi Wanita yang tersebar di 21 kecamatan di kabupaten Jombang, tidak semuanya dalam kondisi aktif. Untuk tahun 2017, sebanyak 70 Koperasi Wanita atau 23%, sampai bulan Juni, belum melakukan Rapat Anggota Tahunan, Ada 19 Koperasi Wanita (kopwan) atau 6% yang menggunakan komputer untuk membantu pencatatan transaksinya. Penerapan Electronic Data Processing dan Faktor pendukung kesuksesan pelaksanaan Electronic Data Processing di Koperasi Wanita kabupaten Jombang sudah baik, Variabel Electronic Data Processing dan Faktor Pendukung Kesuksesan Pelaksanaan Electronic Data Processing berpengaruh terhadap keputusan manajemen Koperasi.
Service Quality In Increasing Participation Of Co-Operative Members
Authors: Silintowe Yunita , Pasharibu Yusepaldo
Published: March 2021

Member participation is a significant element in spurring activity and for maintaining a unifying bond in a co-operative. This study explores service quality's effect on member participation in the primary employee co-operative (primkopkar) Manunggal. This type of research is explanatory with a quantitative approach. The population in this study were members of the Manunggal co-operative, and the sample in this study was 98 people. The data analysis tool used Structural Equation Modeling (SEM), which was processed with the Linear Structural Relationship (LISREL) statistical program. The results showed that service quality had a significant effect on increasing the participation of co-operative members.
Mewujudkan Sistem Peradilan Pidana Terpadu Melalui Case Management System (Studi di Kejaksaan Negeri Kota Bogor)
Authors: Suryadi E. Agus , Supardi H.
Published: March 2021

This legal writing motivated by the efforts made by the Bogor City State Prosecutor”s Office in order to make changes by implementing information technology innovations in handling general criminal cases, especially the handling of narcotics and psychotropic cases in order to realize good and professional governance. System, reduce abuse of power, and curb case administration from the SPDP stage to the implementation stage. The outline of this paper is to discuss the issue of implementing the Case Management System (CMS) in the data input process for handling narcotics and psychotropic crime cases at the Bogor City District Attorney”s Office in realizing an integrated criminal justice system. This research uses statutory, case, comparative, and conceptual approaches. The results showed that the data input process for handling cases of narcotics and psychotropic crimes was in accordance with the SOP, the application of an integrated case handling system in the Information Technology Integrated Case Management System (SPPT-TI) so that it could increase efficiency and effectiveness in case handling. However, there are still obstacles that were face, namely the lack of operator personnel and a lack of understanding of the application of the use of the Case Management System (CMS), but with these obstacles, training on CMS data entry conducted.
Apresentação
Authors: Svartman Eduardo Munhoz
Published: March 2021

Apresentação do Dossiê.
A Síria como ator na Guerra Civil Libanesa: motivações e efeitos da intervenção de uma terceira parte na resolução de conflitos
Authors: Ferreira Marcos Alan S. V. , Santos Vlademir Monteiro dos
Published: March 2021

Entre 1975 e 1991, o Líbano vivenciou uma sangrenta guerra civil, que vitimou aproximadamente cento e vinte mil pessoas. Produto das divisões sectárias em voga desde o período colonial, o conflito colocou cristãos e muçulmanos em confronto, além de ter a participação de terceiros com interesse regional. Apesar do caráter doméstico da guerra, dentre os atores regionais destaca-se a Síria. O comportamento de Damasco como terceira parte não foi homogêneo. Em algumas ocasiões, o governo sírio desempenhou a função de mediador, negociando tréguas entre as facções beligerantes. Em outras, interveio militarmente ou apoiou alguns grupos em detrimento de outros. Neste contexto, o presente artigo propõe-se a examinar o papel sírio na Guerra Civil Libanesa. O objetivo consiste em analisar essa atuação à luz da literatura de resolução de conflitos, em especial aquela que trata da intervenção de uma terceira parte no processo de resolução. Particularmente, será dada ênfase às motivações e aos efeitos da intervenção síria sobre a evolução e o término do conflito libanês. Os resultados demonstram que: a intervenção de uma terceira parte em um conflito doméstico é quase inevitável; sua ação é impelida por motivos diversos e contingentes; e que ela influencia a evolução desse tipo de beligerância.
Um outro general é possível (Entrevista do general espanhol Julio Rodríguez a Alexandre Fuccille)
Authors: Fuccille Alexandre
Published: March 2021

O general Julio Rodríguez foi Chefe do Estado-Maior da Defesa – mais alto cargo militar no Ministério da Defesa da Espanha. Atualmente milita no “Podemos”, partido político de esquerda deste país. Nesta entrevista, fala da transição do franquismo, sobre educação militar, o processo de “civilinização” do Ministério da Defesa, de Justiça Militar, serviço militar obrigatório na atualidade, e outros temas que impactam o campo das relações civis-militares.
A (im)possibilidade do uso de Lethal Autonomous Weapon System frente ao direito internacional humanitário e a ética
Authors: Hupffer Haide Maria , Petry Gabriel Cemin
Published: March 2021

Este artigo discute o uso de Lethal Autonomous Weapon System (armas autônomas capazes de detectar e atacar alvos sem intervenção humana, detendo capacidade de autogoverno) que põe em xeque conceitos éticos e do Direito Internacional Humanitário, pela sua autonomia para realizar a tomada de decisões, como de vida ou morte.
A disputa pela Caxemira entre Índia e Paquistão: chauvinismo e perfil de forças militares
Authors: Neves Jr. Edson Jose
Published: March 2021

O artigo analisa as recentes transformações no conflito pela Caxemira entre Índia e Paquistão, destacando como variáveis relevantes o projeto do governo nacionalista hindu de Narendra Modi e o perfil de forças convencional e modernizado da Índia.
Unasul e União Europeia: análise comparada em termos de Segurança e Defesa
Authors: Neto Tomaz Espósito , Camara Lisa Belmiro
Published: March 2021

Ao se considerar a análise comparada como método ímpar para a compreensão dos mais variados fenômenos — entre eles as dinâmicas do cenário internacional —, este trabalho traça um paralelo entre os órgãos de segurança e defesa da UNASUL e da União Europeia, com o intuito de compreender a lógica da cooperação em segurança e defesa no âmbito das instituições regionais. Como problema de pesquisa, busca-se responder ao questionamento sobre o porquê de a cooperação em temas de segurança e defesa representar uma inflexão, visto que as questões ainda encontram travas que impedem seu aprofundamento no nível regional. Para tanto, a pesquisa se atém ao Conselho de Defesa Sul-Americano (CDS) da Unasul, que representa a primeira iniciativa de cooperação em segurança e defesa entre todos os países da América do Sul, e à Política Comum de Segurança e Defesa (PCSD) da União Europeia, que constitui o atual estágio da integração europeia sobre os referidos temas.
Ensino e Pesquisa como Prática Profissional: Entre Ciência Política, Relações Internacionais e Estudos de Defesa
Authors: Cepik Marco
Published: March 2021

Este texto discute duas dimensões da prática profissional de um professor e pesquisador da área de Ciência Política, Relações Internacionais e Estudos de Defesa. A primeira parte do texto explicita fundamentos do ensino de Teoria de Relações Internacionais. As seções subsequentes discutem os conteúdos da produção científica (a maior parte em coautoria) nas subáreas de Sociologia Histórica, Governança Digital, Estudos de Inteligência e Segurança Internacional. Atualmente, pesquiso os mecanismos sociais que explicam os efeitos recíprocos entre mudanças contextuais (transições globais climáticas, demográficas, energéticas e tecnológicas), estruturas (polaridade e governança) e padrões de interação entre as grandes potências (polarização e cooperação) na configuração da segurança internacional.
Editorial
Authors: Teixeira Júnior Augusto W. M. , Svartman Eduardo Munhoz
Published: March 2021

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A GESTÃO DO PATRIMÔNIO E A RESSIMBOLIZAÇÃO DE CÁRCERES TOMBADOS
Authors: Barradas Maranhão Ana Paula , Socrates Lavalle Sullasi Henry
Published: March 2021

The objective of this work is to analyze the process of cultural heritage policies of former detention houses and understand what their transformation in cultural and tourist instruments. Three old prisons were studied: the “Cadeia Eclesiástica (Aljube)” located in Olinda/PE (current “Museu de Arte Contemporânea de Pernambuco”), The “Casa de Câmara e Cadeia” located in Pirenópolis/GO (current “Museu do Divino Espírito Santo”) and the “Casa de detenção do Recife” (current “Casa da Cultura de Pernambuco”). As methodological procedures were carried out: semi-structured interviews; participant observation; and the survey of official and media documents, discussed under the perspective of the anthropology of heritage and tourism. The analysis of the data shows little memorial and cultural reflexivity on the part of the interviewees. The results show that the prisons in question survive for tourism sustainability, guaranteeing their maintenance, but in a more economical than memorial scope.
Impact of Inoculant Sources on Feed in Vitro Fermentability and Digestibility
Authors: A K Agustina A K Agustina , Evvyernie D , Zahera Rika , Permana I G , Toharmat Toto , Suryahadi S , Despal D
Published: March 2021

The aim of this research is to compare alternative inoculant source for in vitro rumen fermentation. In the first experiment, inoculant from fistulated cattle kept in LIPI and IPB (Fis1 and Fis2) and inoculant from Bogor municipality abattoir and IPB abattoir (Abo1 and Abo2) were tested for their pH, total bacterial count, and protozoal number using a complete block design with four replications. In the second experiment, the effect of the inoculant sources was tested on cornmeal (F1), soybean oil meal (F2), Napier grass (F3), and dairy cattle complete ration (F4) fermentability and digestibility including pH, VFA, NH3, IVDMD and IVOMD parameters. The results showed an unsignificant different protozoal number among inoculant sources. The pH of Fis2 rumen liquor was significantly lower (p<0.05) than others. The bacterial population was significantly higher (p<0.05) in Fis2 and Abo2 than Abo1, and Fis1. The inoculant pH after feed fermentability was not influenced by feed type but inoculant source with Fis1 was significantly higher (p<0.05) than Fis2, Abo2, and Abo1. The ammonia, VFA concentration, IVDMD, and IVOMD were influenced by interaction between inoculant sources and feed types. Although inoculant from cattle close to the laboratory (Fis2 and Abo2) were better in term of higher bacterial population, higher fermentability and digestibility for most type of feeds but other sources can be used in vitro study without differences in average fermentability and digestibility results.

Key words:        abattoir, fermentability, fistula, inoculant, in vitro