bluuebunny/crossref_metadata_2025 huggingface dataset:
Accurate Parameter Estimation of a Hydro-Turbine Regulation System Using Adaptive Fuzzy Particle Swarm Optimization
Authors: Liu Dong , Xiao Zhihuai , Li Hongtao , Liu Dong , Hu Xiao , Malik O.P.
Published: October 2019

Parameter estimation is an important part in the modeling of a hydro-turbine regulation system (HTRS), and the results determine the final accuracy of a model. A hydro-turbine is normally a non-minimum phase system with strong nonlinearity and time-varying parameters. For the parameter estimation of such a nonlinear system, heuristic algorithms are more advantageous than traditional mathematical methods. However, most heuristics based algorithms and their improved versions are not adaptive, which means that the appropriate parameters of an algorithm need to be manually found to keep the algorithm performing optimally in solving similar problems. To solve this problem, an adaptive fuzzy particle swarm optimization (AFPSO) algorithm that dynamically tunes the parameters according to model error is proposed and applied to the parameter estimation of the HTRS. The simulation studies show that the proposed AFPSO contributes to lower model error and higher identification accuracy compared with some traditional heuristic algorithms. Importantly, it avoids a possible deterioration in the performance of an algorithm caused by inappropriate parameter selection.
The Cooling Effect of Large-Scale Urban Parks on Surrounding Area Thermal Comfort
Authors: Aram Farshid , Solgi Ebrahim , Higueras García Ester , Mosavi Amir , R. Várkonyi-Kóczy Annamária
Published: October 2019

This empirical study investigates large urban park cooling effects on the thermal comfort of occupants in the vicinity of the main central park, located in Madrid, Spain. Data were gathered during hot summer days, using mobile observations and a questionnaire. The results showed that the cooling effect of this urban park of 125 ha area at a distance of 150 m could reduce air temperatures by an average of 0.63 °C and 1.28 °C for distances of 380 m and 665 meters from the park. Moreover, the degree of the physiological equivalent temperature (PET) index at a distance of 150 meters from the park is on average 2 °C PET and 2.3 °C PET less compared to distances of 380 m and 665 m, respectively. Considering the distance from the park, the correlation between occupant perceived thermal comfort (PTC) and PET is inverse. That is, augmenting the distance from the park increases PET, while the extent of PTC reduces accordingly. The correlation between these two factors at the nearest and furthest distances from the park is meaningful (p-value < 0.05). The results also showed that large-scale urban parks generally play a significant part in creating a cognitive state of high-perceived thermal comfort spaces for residents.
Linear Active Disturbance Rejection Control for DC Bus Voltage of Permanent Magnet Synchronous Generator Based on Total Disturbance Differential
Authors: Zhou Xuesong , Liu Mao , Ma Youjie , Yang Bao , Zhao Faqing
Published: October 2019

The wind power grid-connected inverter system has nonlinear, strong coupling, and is susceptible to grid voltage fluctuations and nonlinear load effects. To achieve satisfactory control results, the voltage outer loop is controlled by an improved linear active disturbance rejection control (LADRC). LADRC has strong adaptability, robustness and operability. It can automatically detect and compensate for internal and external disturbances, and correct complex controlled objects to integrator series. The total perturbation differential signal is introduced in the traditional linear extended state observer (LESO), which improves the dynamic perturbation observation ability of LESO. The frequency response characteristics analysis shows that the new LADRC has better anti-interference performance. The effectiveness of the improved controller under multiple operating conditions is verified by simulation.
Flue Gas Desulphurization in Circulating Fluidized Beds
Authors: Deng Yimin , Ansart Renaud , Baeyens Jan , Zhang Huili
Published: October 2019

Sulphur dioxide (SO2) is mostly emitted from coal-fueled power plants, from waste incineration, from sulphuric acid manufacturing, from clay brick plants and from treating nonferrous metals. The emission of SO2 needs to be abated. Both wet scrubbing (absorption) and dry or semi-dry (reaction) systems are used. In the dry process, both bubbling and circulating fluidized beds (BFB, CFB) can be used as contactor. Experimental results demonstrate a SO2-removal efficiency in excess of 94% in a CFB application. A general model of the heterogeneous reaction is proposed, combining the external diffusion of SO2 across the gas film, the internal diffusion of SO2 in the porous particles and the reaction as such (irreversible, 1st order). For the reaction of SO2 with a fine particulate reactant, the reaction rate constant and the relevant contact time are the dominant parameters. Application of the model equations reveals that the circulating fluidized bed is the most appropriate technique, where the high solid to gas ratio guarantees a high conversion in a short reaction time. For the CFB operation, the required gas contact time in a CFB at given superficial gas velocities and solids circulation rates will determine the SO2 removal rate.
The Mechanism of Changes in Hydraulic Properties of Populus euphratica in Response to Drought Stress
Authors: Li Duan , Si Jianhua , Zhang Xiaoyou , Gao Yayu , Luo Huan , Qin Jie , Gao Guanlong
Published: October 2019

Stable hydraulic conductivity in forest trees maintains the survival of trees which contribute to productivity in forest ecosystems. Drought conditions break down this relationship, but the mechanisms are poorly known. To increase the understanding of the mechanism of hydraulic characteristics during drought, we determined hydraulic parameters in Populus euphratica Oliv. (P. euphratica) in a time-series of drought using a high-pressure flow meter. We found that P. euphratica could enhance hydraulic transport in severe drought stress under a threshold of soil water content. Drought-induced loss of hydraulic conductance could seriously impair water transport capacity. The soil water content of about 4.5% in the rhizosphere could lead to canopy mortality yet maintain live roots. Hydraulic conductance could be changed under drought stress as a consequence of changes in the anatomical structure and physiology. Furthermore, there was also a trade-off between hydraulic efficiency and safety. The consideration of hydraulic efficiency was first within the range of hydraulic safety limit. Once the hydraulic safety limit was reached, safety would be taken as the first consideration and hydraulic efficiency would be reduced. Research on the mechanism of hydraulic properties in riparian plants in arid areas provides a scientific basis for riparian forest restoration.
Nutrient Composition of Popularly Consumed African and Caribbean Foods in The UK
Authors: Apekey Tanefa A. , Copeman June , Kime Nichola H. , Tashani Osama A. , Kittaneh Monia , Walsh Donna , Maynard Maria J.
Published: October 2019

(1) Background: Traditional foods are important in the diets of Black Africans and Caribbeans and, more widely, influence UK food culture. However, little is known about the nutritional status of these ethnic groups and the nutrient composition of their traditional foods. The aim was to identify and analyse African and Caribbean dishes, snacks and beverages popularly consumed in the UK for energy, macronutrients and micronutrients. (2) Methods: Various approaches including focus group discussions and 24-h dietary recalls were used to identify traditional dishes, snacks, and beverages. Defined criteria were used to prioritise and prepare 33 composite samples for nutrient analysis in a UK accredited laboratory. Quality assurance procedures and data verification were undertaken to ensure inclusion in the UK nutrient database. (3) Results: Energy content ranged from 60 kcal in Malta drink to 619 kcal in the shito sauce. Sucrose levels did not exceed the UK recommendation for adults and children. Most of the dishes contained negligible levels of trans fatty acid. The most abundant minerals were Na, K, Ca, Cu, Mn and Se whereas Mg, P, Fe and Zn were present in small amounts. (4) Conclusion: There was wide variation in the energy, macro- and micronutrients composition of the foods analysed.
Genomics of Avian Viral Infections
Authors: Smith Jacqueline
Published: October 2019

The poultry industry currently accounts for the production of around 118 million metric tons of meat and around 74 million metric tons of eggs annually. As the global population continues to increase, so does our reliance on poultry as a food source. It is therefore of vital importance that we safeguard this valuable resource and make the industry as economically competitive as possible. Avian viral infections, however, continue to cost the poultry industry billions of dollars annually. This can be in terms of vaccination costs, loss of birds and decreased production. With a view to improving the health and welfare of commercial birds and to minimizing associated economic losses, it is therefore of great importance that we try to understand the genetic mechanisms underlying host susceptibility and resilience to some of the major viral pathogens that threaten the poultry species. Some avian viruses, through their zoonotic potential, also pose a risk to human health. This Special Issue will present papers that describe our current knowledge on host responses to various viral pathogens, the genetics underlying those responses and how genomics can begin to provide a solution for resolving the threat posed by these infections.
Effects of Nutrient Composition and Lettuce Cultivar on Crop Production in Hydroponic Culture
Authors: Sapkota Sundar , Sapkota Sanjib , Liu Zhiming
Published: October 2019

A greenhouse research study was conducted at Eastern New Mexico University, Portales, NM, USA, in 2019 to examine the effects of different nutrient solutions on the growth and weight of two lettuce cultivars grown in a floating hydroponic system. Two lettuce cultivars, Buttercrunch and Black Seeded Simpson, were subjected to one of four different nutrient concentrations of N, K and Ca at 150, 100, and 150 ppm (N1), 210, 235, and 200 ppm (N2), 250, 300 and 250 ppm (N3), and 300, 350, and 350 ppm (N4), respectively. The Buttercrunch cultivar and N3 treatment proved significantly more productive than the other cultivar/treatment combinations. The greatest fresh weights were recorded in the N3 nutrient solution, 115.33 and 93.17 g/plant for Buttercrunch and Black Seeded Simpson, respectively. Buttercrunch had the greatest fresh weight, leaf number, and leaf and root length in all nutrient solutions. The nitrogen content of the solutions showed a significant positive relationship with chlorophyll content for both cultivars. It is expected that the development of a cheap and easy-to-use hydroponic system will help growers produce high-quality organic vegetables including lettuce.
The Effect of Dioxin Contamination and Remediation on Property Values
Authors: Zwickle Adam , Cox Jeffrey G. , Zhuang Jie , Hamm Joseph A. , Upham Brad L. , Chung Minwoong , Cruz Shannon , Dearing James W.
Published: October 2019

Loss of property value is a major concern in communities faced with the toxic byproducts of industrial practices. Even after site remediation, stigma may persist and negatively affect market values of residential properties. To study the effects of contamination and of remediation on property values in Midland, Michigan, where dioxins have been released into the environment through the incineration of contaminated waste and the discharge of contaminated water for many years, records of assessed value were obtained for 229 homes within the same neighborhood for the previous 18 years. A multilevel, longitudinal analysis was conducted to determine if there was a relationship between level of dioxin and assessed value after controlling for housing characteristics. Remediated and un-remediated properties saw increases in value at a similar rate over time. However, a property’s level of dioxin was found to have a small, significant, and negative relationship with assessed value, and this negative effect was present regardless if a home had been remediated or not. These results suggest that while environmental remediation may be effective at removing the contamination, its economic effects may persist for a longer period of time.
Exploring Epidemiological Characteristics of Domestic Imported Dengue Fever in Mainland China, 2014–2018
Authors: Yue Yujuan , Liu Qiyong
Published: October 2019

Epidemiological characteristics of domestic imported dengue fever in mainland China, 2014–2018, including time-series, spatial mobility and crowd features, were analyzed. There existed seasonal characteristics from August to November. The 872 domestic imported cases from 8 provinces, located in the southeastern, southwestern and southern coastal or border areas, were imported to 267 counties in 20 provinces of mainland China, located in the outer areas along the southwest-northeast line. The 628 domestic imported cases were still imported to the adjacent counties in the provinces themselves, 234 domestic imported cases were imported to 12 other provinces except the 8 original exported provinces, 493 cases in 2014 reached the peak, and 816 domestic imported cases were from Guangdong (675) and Yunnan (141). Domestic imported cases from Guangdong were imported to 218 counties, and 475 cases from Guangdong were imported to the adjacent counties in Guangdong itself. There were more male cases than female cases except in 2016. Domestic imported cases were clustered from 21 to 50 years old. The top three cases were from farmer, worker and housework or unemployed. The findings are helpful to formulate targeted, strategic plans and implement effective public health prevention and control measures.
Water Quality of the Mun River in Thailand—Spatiotemporal Variations and Potential Causes
Authors: Tian Haoyu , Yu Guo-An , Tong Ling , Li Renzhi , Huang He Qing , Bridhikitti Arika , Prabamroong Thayukorn
Published: October 2019

The water quality of the Mun River, one of the largest tributaries of the Mekong River and an important agricultural area in Thailand, is investigated to determine its status, identify spatiotemporal variations and distinguish the potential causes. Water quality dataset based on monitoring in the last two decades (1997–2017) from 21 monitoring sites distributed across the basin were analyzed using seasonal Kendall test and water quality index (WQI) method. The Kendall test shows significant declines in fecal coliform bacteria (FCB) and ammonia (NH3) in the upper reaches and increases in nitrate (NO3) and NH3 in the lower reaches. Strong temporal and spatial fluctuations were observed in both the concentrations of individual parameters and the WQI values. Seasonal variation of water quality was observed at each monitoring site. WQI values in August (flood season) were generally among the lowest, compared to other seasons. Spatially, sites in the upper reaches generally having lower WQI values than those in the lower reaches. Excessive phosphorus is the primary cause of water quality degradation in the upper reaches, while nitrogen is the primary parameter for water quality degradation in the lower reaches. Urban built-up land is an important “source” of water pollutants in the lower basin, while agricultural land plays a dual role, affecting across the basin.
Hydrotransport-Oriented Zn, Cu, and Pb Behavior Assessment and Source Identification in the River Network of a Historically Mined Area in the Hokuroku Basin, Northeast Japan
Authors: Lu Qingqing , Bian Zhengfu , Tsuchiya Noriyoshi
Published: October 2019

Aquatic ecosystems continuously receive potentially hazardous heavy metals from natural and anthropogenic sources. Focusing on the origin of heavy metals, this study aims to estimate the load contribution of tributaries from individual watershed and human drainage and to dissect the source of heavy metals, as commonly required for environmental impact assessment. Using integrated water dynamics, Geographic Information System (GIS), and chemical analysis, we identified and evaluated the heavy metal sources of the Kosaka river system in Hokuroku basin, which is a historically mined area in Northeast Japan, both in the high-water and low-water seasons. The migration and diffusion behaviors of heavy metals along with hydro-transport were analyzed, and the effects of mining activities on regional water quality both in the high-water and low-water seasons were clarified. The results indicate that Zn pollution was obvious in the Kosaka River network, especially in the downstream area. The spatial heterogeneity of heavy metal outflows from tributary watersheds was obvious, and the variations had strong correlations with mine site locations. The heavy metal flows in the mainstream increased sharply in the vicinity downstream of the Kosaka refinery drainage outlets. Compared to the low-water season, the influences of human drainage were slighter in high-water season, with lower contribution rates due to the dilution effect of the greater water discharge. Downscale sampling is effective to identify pollutant sources in regional basins.
Association of Perceived Built Environment Attributes with Objectively Measured Physical Activity in Community-Dwelling Ambulatory Patients with Stroke
Authors: Kanai Masashi , Izawa Kazuhiro P. , Kubo Hiroki , Nozoe Masafumi , Mase Kyoshi , Koohsari Mohammad Javad , Oka Koichiro , Shimada Shinichi
Published: October 2019

There is little evidence on how perceptions of the built environment may influence physical activity among post-stroke patients. This study aimed to explore the associations between perceived built environment attributes and objectively measured physical activity outcomes in community-dwelling ambulatory patients with stroke. This cross-sectional study recruited patients who could walk outside without assistance. We assessed both objectively measured physical activity outcomes such as number of steps and duration of moderate-to-vigorous physical activity (MVPA) with an accelerometer and the patients’ perceived surrounding built environment with the International Physical Activity Questionnaire Environmental Module. Sixty-one patients (67.0 years old) were included. The multiple linear regression analysis showed significant associations of the presence of sidewalks (β = 0.274, p = 0.016) and access to recreational facilities (β = 0.284, p = 0.010) with the number of steps taken (adjusted R2 = 0.33). In contrast, no significant associations were found between perceived built environment attributes and MVPA. These findings may help to suggest an approach to promote appropriate physical activity in patients with stroke depending on their surrounding built environment.
Remarkable Reduction of Cocaine Use in Dual Disorder (Adult Attention Deficit Hyperactive Disorder/Cocaine Use Disorder) Patients Treated with Medications for ADHD
Authors: Manni Corrado , Cipollone Giada , Pallucchini Alessandro , Maremmani Angelo G. I. , Perugi Giulio , Maremmani Icro
Published: October 2019

Background: Cocaine use disorder (CUD) is a growing public health concern, but so far no effective pharmacotherapies have been demonstrated. Stimulant medications have proved to be promising in CUD treatment. The self-medication hypothesis (SMH) can help to explain this phenomenon better, especially in cases where CUD co-occurs with adult attention deficit hyperactivity disorder (A-ADHD). Methods: In the present retrospective study, a sample of 20 consecutive patients (aged from 18 to 65 years) with dual disorder (A-ADHD/CUD), under treatment with methylphenidate (MPH) or atomoxetine (ATM) medications, was followed to study the effects of A-ADHD treatment on cocaine use. Patients were followed for a mean period of 7 months (minimum 1, maximum 30 months). All individuals were assessed with standardized questionnaires to evaluate diagnosis, treatment efficacy, and clinical improvement. Results: the results showed that behaviors reflecting cocaine addiction were sharply reduced during the stimulant treatment of A-ADHD, and were not correlated with age, gender, familiarity, length of treatment, or medication used. CUD improvement was closely correlated with the A-ADHD improvement. This study supports the validity of the SMH in ADHD patients with co-occurring CUD.
Exercise as an Alternative Approach for Treating Smartphone Addiction: A Systematic Review and Meta-Analysis of Random Controlled Trials
Authors: Liu Shijie , Xiao Tao , Yang Lin , Loprinzi Paul D.
Published: October 2019

Background: With the emergence of electronic products, smartphones have become an indispensable tool in our daily life. On the other hand, smartphone addiction has become a public health issue. To help reduce smartphone addiction, cost-effective interventions such as exercise are encouraged. Purpose: We therefore performed a systematic review and meta-analysis evaluating existing literature on the rehabilitative effects of exercise interventions for individuals with a smartphone addiction. Methods: We searched PubMed, Web of Science, Scopus, CNKI, and Wanfang from inception to September 2019. Nine eligible randomized controlled trials (RCT) were finally included for meta-analysis (SMD represents the magnitude of effect of exercise) and their methodological quality were assessed using the PEDro scale. Results: We found significant positive effects of exercise interventions (Taichi, basketball, badminton, dance, run, and bicycle) on reducing the total score (SMD = −1.30, 95% CI −1.53 to −1.07, p < 0.005, I2 = 62%) of smartphone addiction level and its four subscales (withdrawal symptom: SMD = −1.40, 95% CI −1.73 to −1.07, p < 0.001, I2 = 81%; highlight behavior: SMD = −1.95, 95% CI −2.99 to −1.66, p < 0.001, I2 = 79%; social comfort: SMD = −0.99, 95% CI −1.18 to −0.81, p = 0.27, I2 = 21%; mood change: SMD = −0.50, 95% CI 0.31 to 0.69, p = 0.25, I2 = 25%). Furthermore, we found that individuals with severe addiction level (SMD = −1.19, I2 = 0%, 95%CI:−1.19 to −0.98) benefited more from exercise engagement, as compared to those with mild to moderate addiction levels (SMD = − 0.98, I2 = 50%, 95%CI:−1.31 to −0.66); individuals with smartphone addiction who participated in exercise programs of 12 weeks and above showed significantly greater reduction on the total score (SMD = −1.70, I2 = 31.2%, 95% CI −2.04 to −1.36, p = 0.03), as compared to those who participated in less than 12 weeks of exercise intervention (SMD = −1.18, I2 = 0%, 95% CI−1.35 to −1.02, p < 0.00001). In addition, individuals with smartphone addiction who participated in exercise of closed motor skills showed significantly greater reduction on the total score (SMD = −1.22, I2 = 0 %, 95% CI −1.41 to −1.02, p = 0.56), as compared to those who participated in exercise of open motor skills (SMD = −1.17, I2 = 44%, 95% CI−1.47 to −0.0.87, p = 0.03). Conclusions: Exercise interventions may have positive effects on treating smartphone addiction and longer intervention durations may produce greater intervention effects.
Skin Melanoma and Subsequent Risk of Prostate Cancer: A Lithuanian Cancer Registry Study
Authors: Patasius Ausvydas , Urbonas Vincas , Smailyte Giedre
Published: October 2019

Emerging data indicates that melanoma may be linked to prostate cancer. We evaluated if the incidence of melanoma was associated with subsequent risk of prostate cancer (PC). We extracted data from the Lithuanian cancer registry from 1993 to 2012. We calculated the standardized incidence ratios (SIRs) for PC as a ratio of observed number of cancer cases in people with previous melanoma diagnosis to the expected number of cancer cases in the underlying general population. Therein, 95% confidence intervals for the SIRs were estimated assuming the number of observed cancer cases follows the Poisson distribution. Overall, 65 PCs were observed versus 52.5 expected (SIR 1.24; 95% CI: 0.97–1.58) within a period of 24 years. A significantly increased risk of PC was found in patients with melanoma diagnosis over 70 years (SIR 1.62; 95% CI: 1.11–2.39) and in two periods of diagnosis (SIRs 1.76 and 1.62 in 1993–1997 and 2009–2012, respectively). A significantly increased risk was also found five to nine years after melanoma diagnosis (SIR 1.58; 95% CI: 1.05–2.38). Further studies are needed to evaluate the relationship between melanoma and subsequent risk of prostate cancer.
Exhaled Carbon Monoxide Levels in Forty Resistant to Cessation Male Smokers after Six Months of Full Switch to Electronic Cigarettes (e-Cigs) or to A Tobacco Heating Systems (THS)
Authors: Beatrice Fabio , Massaro Giuseppina
Published: October 2019

Cigarette smoke releases several toxic chemicals and carcinogens including carbon monoxide (CO). This study examined the levels of exhaled CO in smokers switching to electronic cigarettes (e-Cigs) or a tobacco heating system (THS) and their level of compliance six months after switching. On the basis of their own preferences, 40 male smokers unwilling or unable to stop smoking were switched to e-Cigs or THSs for six months (20 subjects in each group). Nicotine addiction and levels of carbon monoxide in the exhaled breath (eCO) were measured at baseline (the latter also at six months). The Shapiro Wilk test, graphical methods, Student T test or Mann–Whitney test were used to assess the normal distribution of variables and differences between the two groups after six months. The two groups showed no difference at baseline, but a significant higher addiction score in smokers choosing THS. E-Cig and THS showed significant reduced levels of eCO (both %COHb and COppm) after six months, which were within the range of non-smoker status. Reduced levels of %COHb did not significantly differ between the two groups, whilst the THS group had a significantly lower reduction in levels of COppm vs the e-Cig group (p < 0.05). Both e-Cigs and THSs are capable of significantly reducing eCO at least in the medium term, hence constituting a viable tobacco harm reduction approach in smokers who are unwilling or unable to stop smoking.
The Effect of Health Worker Training on Early Initiation of Breastfeeding in South Sudan: A Hospital-based before and after Study
Authors: Tongun Justin Bruno , Tumwine James K , Ndeezi Grace , Sebit Mohamedi Boy , Mukunya David , Nankunda Jolly , Tylleskar Thorkild
Published: October 2019

Globally, suboptimal breastfeeding contributes to more than 800,000 child deaths annually. In South Sudan, few women breastfeed early. We assessed the effect of a Baby-Friendly Hospital Initiative training on early initiation of breastfeeding at Juba Teaching Hospital in South Sudan. We carried out the training for health workers after a baseline survey. We recruited 806 mothers both before and four to six months after training. We used a modified Poisson model to assess the effect of training. The prevalence of early initiation of breastfeeding increased from 48% (388/806) before to 91% (732/806) after training. Similarly, early initiation of breastfeeding increased from 3% (3/97) before to 60% (12/20) after training among women who delivered by caesarean section. About 8% (67/806) of mothers discarded colostrum before compared to 3% (24/806) after training. Further, 17% (134/806) of mothers used pre-lacteal feeds before compared to only 2% (15/806) after training. Regardless of the mode of birth, the intervention was effective in increasing early initiation of breastfeeding [adjusted prevalence ratio (APR) 1.69, 95% confidence interval CI (1.57-1.82)]. These findings suggest an urgent need to roll out the training to other hospitals in South Sudan. This will result in improved breastfeeding practices, maternal, and infant health.
“Language Breathes Life”—Barngarla Community Perspectives on the Wellbeing Impacts of Reclaiming a Dormant Australian Aboriginal Language
Authors: Sivak Leda , Westhead Seth , Richards Emmalene , Atkinson Stephen , Richards Jenna , Dare Harold , Zuckermann Ghil’ad , Gee Graham , Wright Michael , Rosen Alan , Walsh Michael , Brown Ngiare , Brown Alex
Published: October 2019

Traditional languages are a key element of Indigenous peoples’ identity, cultural expression, autonomy, spiritual and intellectual sovereignty, and wellbeing. While the links between Indigenous language loss and poor mental health have been demonstrated in several settings, little research has sought to identify the potential psychological benefits that may derive from language reclamation. The revival of the Barngarla language on the Eyre Peninsula, South Australia, offers a unique opportunity to examine whether improvements in mental health and social and emotional wellbeing can occur during and following the language reclamation process. This paper presents findings from 16 semi-structured interviews conducted with Barngarla community members describing their own experienced or observed mental health and wellbeing impacts of language reclamation activities. Aligning with a social and emotional wellbeing framework from an Aboriginal and Torres Strait Islander perspective, key themes included connection to spirituality and ancestors; connection to Country; connection to culture; connection to community; connection to family and kinship; connection to mind and emotions; and impacts upon identity and cultural pride at an individual level. These themes will form the foundation of assessment of the impacts of language reclamation in future stages of the project.
Social and Psychological Predictors of Body Mass Index among South Africans 15 Years and Older: SANHANES-1
Authors: Mchiza Zandile June-Rose , Parker Whadi-Ah , Hossin Muhammad Zakir , Heshmati Amy , Labadarios Demetre , Falkstedt Daniel , Koupil Ilona
Published: October 2019

This study investigated how psychological distress and the proxies for social position combine to influence the risk of both underweight and overweight in South Africans aged 15 years and older. This was a cross-sectional study that included 2254 men and 4170 women participating in the first South African National Health and Nutrition Examination Survey (SANHANES-1). An analysis exploring the associations of social and mental health characteristics with body mass index (BMI) was conducted using binary and multinomial logistic regressions. Results suggested that, overall, women had a higher risk of overweight/obesity compared to men (age-adjusted odds ratio [AOR] 4.65; 95% confidence intervals [CI] 3.94–5.50). The gender effect on BMI was smaller in non-African participants (AOR 3.02; 95% CI 2.41–3.79; p-value for interaction = 0.004). Being employed and having a higher level of education were associated with higher risks of overweight and obesity and a lower risk of underweight. Being single or without a spouse and poor mental health were found to increase the odds of being underweight, especially in men. To conclude, there are strong social gradients and important gender and ethnic differences in how BMI is distributed in the South African population.
Effect of Native and Acetylated Dietary Resistant Starches on Intestinal Fermentative Capacity of Normal and Stunted Children in Southern India
Authors: Balamurugan Ramadass , Pugazhendhi Srinivasan , Balachander Gowri M. , Dharmalingam Tamilselvan , Mortimer Elissa K , Gopalsamy Geetha L. , Woodman Richard J. , Meng Rosie , Alpers David H. , Manary Mark , Binder Henry J. , Brown Ian L. , Young Graeme P. , Ramakrishna Balakrishnan S.
Published: October 2019

The health benefits of dietary amylase resistant starch (RS) arise from intestinal microbial fermentation and generation of short chain fatty acids (SCFA). We compared the intestinal fermentative capability of stunted and nonstunted (‘healthy’) children in southern India using two types of RS: high amylose maize starch (HAMS) and acetylated HAMS (HAMSA). Twenty children (10 stunted and 10 healthy) aged 2 to 5 years were fed biscuits containing HAMS (10 g/day) for two weeks followed by a 2-week washout and then HAMSA biscuits (10 g/day) for 2 weeks. Fecal samples were collected at 3-4 day intervals and pH and SCFA analyzed. At entry, stunted children had lower SCFA concentrations compared to healthy children. Both types of RS led to a significant decrease in fecal pH and increase in fecal acetate and propionate in both healthy and stunted children. However, while HAMS increased fecal butyrate in both groups of children, HAMSA increased butyrate in healthy but not stunted children. Furthermore, healthy children showed a significantly greater increase than stunted children in both acetate and butyrate when fed either RS. No adverse effects were reported with either RS. Stunted children have impaired capacity to ferment certain types of RS which has implications for choice of RS in formulations aimed at improving microbial function in stunted children.
Positive Outcomes of a Comprehensive Health Literacy Communication Training for Health Professionals in Three European Countries: A Multi-centre Pre-post Intervention Study
Authors: Kaper Marise S. , Winter Andrea F. de , Bevilacqua Roberta , Giammarchi Cinzia , McCusker Anne , Sixsmith Jane , Koot Jaap A.R. , Reijneveld Sijmen A.
Published: October 2019

Many professionals have limited knowledge of how to address health literacy; they need a wider range of health literacy competencies to enhance empowerment and person-centred prevention. We evaluated whether: (1) a comprehensive health literacy training increased self-rated competencies of health professionals to address health literacy related problems and support the development of people’s autonomy and self-management abilities after training and 6–12 weeks later, (2) professionals were satisfied with the training, (3) outcomes differed for the three participating European countries. Health professionals (N = 106) participated in a multicentre pre-post intervention study in Italy, the Netherlands and Northern Ireland. The 8-hour training-intervention involved health literacy knowledge, the practice of comprehensible communication skills, shared decision-making, and enhancing self-management. Self-rated health literacy competencies and training satisfaction were assessed at baseline, immediately after training and 6-12 weeks later, and analysed by multi-level analysis. Professionals’ self-rated health literacy competencies significantly improved following training in all three countries; this increase persisted at 6-12 weeks follow-up. The strongest increase regarded professional’s skills to enhance shared-decision making and enabling self-management after training and follow-up respectively. Professionals perceived the training as relevant for practice. Competency increases seemed to be consistent across countries. In three countries, professionals’ self-rated health literacy competencies increased following this comprehensive training. These promising findings should be confirmed in a further full effect study. Implementation of this training in European education and health care may improve person-centred communication by professionals and might help to tackle health literacy related problems and to strengthen people’s abilities in achieving better health outcomes.
Hyperhidrosis, Endoscopic Thoracic Sympathectomy, and Cardiovascular Outcomes: A Cohort Study Based on the Korean Health Insurance Review and Assessment Service Database
Authors: Park Jae-Min , Moon Duk Hwan , Lee Hye Sun , Park Ju-young , Lee Ji-Won , Lee Sungsoo
Published: October 2019

Sympathetic overactivity is associated with hyperhidrosis and cardiovascular diseases. Endoscopic thoracic sympathectomy (ETS) is a treatment for hyperhidrosis. We aimed to compare the risk for cardiovascular events between individuals with and without hyperhidrosis and investigate the effects of ETS on cardiovascular outcomes. We conducted a nationwide population-based cohort study using data acquired from the Korean Health Insurance Review and Assessment Service. Subjects newly diagnosed with hyperhidrosis in 2010 were identified and divided into two groups according to whether or not they underwent ETS. Propensity scores were calculated using a logistic regression model to match hyperhidrosis patients with control subjects. Combined cardiovascular events were defined as stroke and ischemic heart diseases. Subjects were followed up until the first cardiovascular event or 31 December 2017. The risk for cardiovascular events with hyperhidrosis and ETS was analyzed using Cox proportional hazards regression analysis. The risk for stroke was significantly higher in the hyperhidrosis group than in the control group (hazard ratio (HR), 1.28; 95% confidence interval (CI), 1.08–1.51); nonetheless, no significant difference in the risk for ischemic heart diseases was observed between the hyperhidrosis group and the control group (HR, 1.17; 95% CI, 0.99–1.31). Hyperhidrosis patients who did not undergo ETS were at significantly higher risk for cardiovascular events than the control group (HR, 1.28; 95% CI, 1.13–1.45). However, no significant difference in the risk for cardiovascular events was observed between hyperhidrosis patients who underwent ETS and the control group. Hyperhidrosis increases the risk for cardiovascular events. ETS could reduce this risk and needs to be considered for high-risk patients with cardiovascular diseases.
Relationship between Foreign Macroeconomic Conditions and Asian-Pacific Public Real Estate Markets: The Relative Influence of the US and China
Authors: Liow Kim Hiang , Huang Yuting , Heng Kai Li
Published: October 2019

The aim of this paper was to examine the relationship between changes in the US and China macroeconomic conditions and the excess returns of nine Asian-Pacific public real estate markets (Singapore, Indonesia, Malaysia, the Philippines, Thailand, Australia, Taiwan, Hong Kong, and Japan). We found that there are insignificant correlations between macroeconomic conditions in the US and China and the real estate markets’ excess returns. Additionally, whilst the US macroeconomic factors show stronger causal relationships with the real estate markets in the long run, China’s macroeconomic variables have experienced a stronger causal relationship in the short run. Finally, key macroeconomic variables, such as the industrial production output index, long-term interest rates, and economic policy uncertainty, produced fluctuating impulse responses to shocks from the US and China. Overall, we conclude that the US economy continues to have a dominant influence in the Asian-Pacific real estate markets. However, during economic crises and in the short run, the impact of China’s economy grows significantly and outweighs that of the US In the context that a high degree of economic and financial integration has affected the interdependent level of international financial markets, the Asian-Pacific securitized real estate markets’ performances are also impacted by global shocks.
Financial Innovation and Financial Inclusion Nexus in South Asian Countries: Evidence from Symmetric and Asymmetric Panel Investigation
Authors: Qamruzzaman Md. , Wei Jianguo
Published: October 2019

This paper examines the nexus between financial inclusion and financial innovation while incorporating financial development and remittance inflows in the case of six South Asian countries—Bangladesh, India, Pakistan, Nepal, Bhutan, and Srilanka—by employing the panel autoregressive distributed lagged model under a linear and nonlinear framework using monthly data over the period 1990M1–2018M12. Further, a Granger-causality test with System GMM specification was performed for assessing directional causality. The study findings from Panel ARDL confirmed the positive association between financial innovation and financial inclusion, which was observed both in the long run and short-run. Considering the nonlinearity in the estimation, the standard Wald test confirms the existence of an asymmetric relationship both in the short-run and in long run horizon regarding causality test results. The study findings support the feedback hypothesis that the presence of bidirectional causality between the financial innovation and financial inclusion is both in the short-run and long run. Since the study findings established a critical relationship between financial innovation and financial inclusion, therefore effective policy guidelines are suggested so that the contribution from financial inclusion and financial innovation can assist in developing a vibrant financial sector.
Corporate Governance, Political Connections, and Bank Performance
Authors: Haris Muhammad , Yao Hongxing , Tariq Gulzara , Javaid Hafiz Mustansar , Ain Qurat Ul
Published: October 2019

This study investigates the impact of corporate governance characteristics and political connections of directors on the profitability of banks in Pakistan. The study uses the data of 26 domestic banks over the latest and large period of 2007–2016. Our findings firstly affirm that bank profitability is negatively affected by the presence of politically connected directors on the board, reporting significantly lower return on assets, return on equity, net interest margin, and profit margin. Secondly, our findings also affirm the negative political influence on the sustainability of the banking industry, reporting significantly lower return on assets, return on equity, net interest margin, and profit margin during the government transition of banks having politically connected directors sitting on their board. Our findings further report an inverted U-shaped relationship between board size and bank profitability, suggesting that a board size beyond 8–9 members decreases the profitability. The study further finds a positive impact of board composition, board independence, and director compensation on bank profitability, while also finding a negative impact of frequent board meetings, presence of foreign directors, and audit committee independence.
Light-Regulation of Tryptophan Synthase by Combining Protein Design and Enzymology
Authors: Kneuttinger Andrea C. , Zwisele Stefanie , Straub Kristina , Bruckmann Astrid , Busch Florian , Kinateder Thomas , Gaim Barbara , Wysocki Vicki H. , Merkl Rainer , Sterner Reinhard
Published: October 2019

The spatiotemporal control of enzymes by light is of growing importance for industrial biocatalysis. Within this context, the photo-control of allosteric interactions in enzyme complexes, common to practically all metabolic pathways, is particularly relevant. A prominent example of a metabolic complex with a high application potential is tryptophan synthase from Salmonella typhimurium (TS), in which the constituting TrpA and TrpB subunits mutually stimulate each other via a sophisticated allosteric network. To control TS allostery with light, we incorporated the unnatural amino acid o-nitrobenzyl-O-tyrosine (ONBY) at seven strategic positions of TrpA and TrpB. Initial screening experiments showed that ONBY in position 58 of TrpA (aL58ONBY) inhibits TS activity most effectively. Upon UV irradiation, ONBY decages to tyrosine, largely restoring the capacity of TS. Biochemical characterization, extensive steady-state enzyme kinetics, and titration studies uncovered the impact of aL58ONBY on the activities of TrpA and TrpB and identified reaction conditions under which the influence of ONBY decaging on allostery reaches its full potential. By applying those optimal conditions, we succeeded to directly light-activate TS(aL58ONBY) by a factor of ~100. Our findings show that rational protein design with a photo-sensitive unnatural amino acid combined with extensive enzymology is a powerful tool to fine-tune allosteric light-activation of a central metabolic enzyme complex.
Pyridine-Containing Macrocycles Display MMP-2/9 Inhibitory Activity and Distinct Effects on Migration and Invasion of 2D and 3D Breast Cancer Models
Authors: Proença Susana , Antunes Bernardo , Guedes Rita C. , Ramilo-Gomes Filipa , Cabral M. Fátima , Costa Judite , Fernandes Ana S. , Castro Matilde , Oliveira Nuno G. , Miranda Joana P.
Published: October 2019

The role of metalloproteinases (MMPs) on the migration and invasion of cancer cells has been correlated with tumor aggressiveness, namely with the up-regulation of MMP-2 and 9. Herein, two pyridine-containing macrocyclic compounds, [15]pyN5 and [16]pyN5, were synthesized, chemically characterized and evaluated as potential MMP inhibitors for breast cancer therapy using 3D and 2D cellular models. [15]pyN5 and [16]pyN5 (5–20 µM) showed a marked inhibition of MMPs activity (100% at concentrations ≥ 7.5 μM) when compared to ARP-100, a known MMP inhibitor. The inhibitory activity of [15]pyN5 and [16]pyN5 was further supported through in silico docking studies using Goldscore and ChemPLP scoring functions. Moreover, although no significant differences were observed in the invasion studies in the presence of all MMPs inhibitors, cell migration was significantly inhibited by both pyridine-containing macrocycles at concentrations above 5 μM in 2D cells (p < 0.05). In spheroids, the same effect was observed, but only with [16]pyN5 at 20 μM and ARP-100 at 40 μM. Overall, [15]pyN5 and [16]pyN5 led to impaired breast cancer cell migration and revealed to be potential inhibitors of MMPs 2 and 9.
Prognostic Value of the Echocardiographic Probability of Pulmonary Hypertension in Patients with Acute Decompensated Heart Failure
Authors: Carballo Sebastian , Musso Philippe , Garin Nicolas , Müller Hajo , Serratrice Jacques , Mach François , Carballo David , Stirnemann Jérôme
Published: October 2019

The prognostic value of pulmonary hypertension (PH) estimated by echocardiography in unselected patients with acute decompensated heart failure (ADHF) is poorly studied. Between November 2014 and September 2018, 657 patients were recruited in a prospective registry of ADHF (ClinicalTrials.gov NCT02444416). The probability of pulmonary hypertension was based on European Society of Cardiology (ESC) guidelines for echocardiographic evaluation. The median survival without all-cause mortality or readmission was 7 months. During the median follow-up period of 15 months, there were 450 events including 185 deaths. In multivariate analysis, the hazard ratio (HR) of all-cause mortality or readmission for patients with a high probability of PH was 1.67 (95% CI 1.29–2.17, p < 0.001) as compared to patients with a low or intermediate probability. The left ventricular ejection fraction (LVEF) and right ventricular function (RVF) were not associated with the primary outcome—HR 1.02 (95% CI 0.81–1.29; p = 0.84) and 0.96 (95% CI 0.76–1.23; p = 0.77) respectively. In patients admitted for ADHF, a high probability of PH as evaluated by echocardiography provided the highest independent prognostic value for mortality and readmission, whereas LVEF and RVF were not associated with prognosis. The identification of patients at high risk of PH by non-invasive measurement conveys important prognostic information and may guide management.