bluuebunny/crossref_metadata_2025 huggingface dataset:
'Self-being' and 'Becoming a teacher' with Nature-Friendly Play: Focusing on the Philosophical Thinking of Post-Structuralism by Deleuze
Authors: Yoo Seung-Yoeun ,   The Korea Associantion For Early Childhood Education Administration
Published: July 2024

This study was commenced as an attempt to illuminate the relationship between children’s play patterns and teachers’ personal lives in nature-friendly play by the revised Nuri Curriculum based on Deleuze’s philosophical perspective. The research had been conducted for three years from 2022 with a teacher with 10 years of experience and 5 year-old children in a private kindergarten located in S city. The researcher observed the development of children’s play patterns and conducted observations and interviews with the teacher. This study was also intended to explore how indoor and outdoor play spaces are formed and evolved in creation and extinction, focusing on the flexibility of children’s play and the teacher-child interactions. The basic data including teachers' reflective journals, play videos, teacher interviews, and anecdotal record were analyzed through the post-qualification research method.
As the result of this study, the life history and beliefs of a teacher as well as her thoughts based on educational philosophy were found to have a vivid effect on teacher’s flexibility and nomadic characteristics in children’s play. This result is considered to be very significant in exploring the teachers’ attitudes and support required in children’s free and creative play that the revised Nuri Curriculum aims for.
A Study on the social demands for Policy of Integration of Early Childhood Education and Childcare
Authors: Ko Jea-Ug ,   The Korea Associantion For Early Childhood Education Administration
Published: July 2024

This study investigated the social demands of experts in setting the policy direction for convergence of Confucianism. The subjects were public and private kindergartens, workers at national and public daycare centers, and academic experts located across the country. The research method was to analyze a total of 2,246 questionnaires from a randomly selected sample.
As a result of the study, first, the administrative central ministries that were divided into the Ministry of Education and the Ministry of Health and Welfare were integrated into the Ministry of Education. Second, in the qualifications required for kindergarten and integrated teachers, the current kindergarten teachers and childcare teachers are mixed depending on the type of program, and the university obtains teacher qualifications. An opinion was presented to divide the students into levels according to their educational background. Third, among the stakeholders who benefited from the consolidation of kindergartens, parents appeared to be the most likely. Fourth, the response was that the integration of kindergartens should be preceded by the integration of the administrative organization of central government agencies. Fifth, as a result of analyzing the names and operation directions of infants and toddlers according to the integration of kindergartens, the method of separating children by age during the integration of kindergartens It was said that children aged 3 to 5 were separated. Sixth, opinions on the name of the integrated kindergarten were answered in the following order: infant school, children's school, and play school. The conclusion of the study is that in order to promote kindergarten integration, it is necessary to provide high-quality education and childcare services that make infants and toddlers happy by considering the opinions of various stakeholders.
GLP-1 Receptor Agonist Treatment Improves Fasting and Postprandial Lipidomic Profiles Independently of Diabetes and Weight Loss
Authors: Della Pepa Giuseppe , Patrício Bárbara G. , Carli Fabrizia , Sabatini Silvia , Astiarraga Brenno , Ferrannini Ele , Camastra Stefania , Gastaldelli Amalia
Published: July 2024

Treatment with glucagon-like peptide 1 receptor agonists reduces liver steatosis and cardiometabolic risk (CMR). Few data are available on lipid metabolism, and no information is available on the postprandial lipidomic profile. Thus, we investigated how exenatide treatment changes lipid metabolism and composition during fasting and after a mixed-meal tolerance test (MMTT) in adults with severe obesity without diabetes. Thirty individuals (26 females and 4 males, 30–60 years old, BMI >40 kg/m2, HbA1c 5.76%) were assigned (1:1) to diet with exenatide 10 μg twice daily treatment (n = 15) or without treatment as control (n = 15) for 3 months. Fasting and postprandial lipidomic profile (by liquid chromatography quadrupole time-of-flight mass spectrometry) and fatty acid metabolism (following a 6-h MMTT/tracer study) and composition (by gas chromatography-mass spectrometry) were evaluated before and after treatment. Both groups had slight weight loss (−5.5% vs. −1.9%, exenatide vs. control; P = 0.052). During fasting, exenatide, compared with control, reduced some ceramides (CERs) and lysophosphatidylcholines (LPCs) previously associated with CMR, while relatively increasing unsaturated phospholipid species (phosphatidylcholine [PC], LPC) with protective effects on CMR, although concentrations of total lipid species were unchanged. During MMTT, both groups showed suppressed lipolysis equal to baseline, but exenatide significantly lowered free fatty acid clearance and postprandial triacyclglycerol (TAG) concentrations, particularly saturated TAGs with 44–54 carbons. Exenatide also reduced some postprandial CERs, PCs, and LPCs previously linked to CMR. These changes in lipidomic profile remained statistically significant after adjusting for weight loss. Exenatide improved fasting and postprandial lipidomic profiles associated with CMR mainly by reducing saturated postprandial TAGs and CERs independently of weight loss and diabetes.

Article Highlights
REDD1 Is a Promising Therapeutic Target to Combat the Development of Diabetes Complications: A Report on Research Supported by Pathway to Stop Diabetes
Authors: Sunilkumar Siddharth , Dennis Michael D.
Published: July 2024

The stress response protein regulated in development and DNA damage response 1 (REDD1) has emerged as a key player in the pathogenesis of diabetes. Diabetes upregulates REDD1 in a variety of insulin-sensitive tissues, where the protein acts to inhibit signal transduction downstream of the insulin receptor. REDD1 functions as a cytosolic redox sensor that suppresses Akt/mTORC1 signaling to reduce energy expenditure in response to cellular stress. Whereas a transient increase in REDD1 contributes to an adaptive cellular response, chronically elevated REDD1 levels are implicated in disease progression. Recent studies highlight the remarkable benefits of both whole-body and tissue-specific REDD1 deletion in preclinical models of type 1 and type 2 diabetes. In particular, REDD1 is necessary for the development of glucose intolerance and the consequent rise in oxidative stress and inflammation. Here, we review studies that support a role for chronically elevated REDD1 levels in the development of diabetes complications, reflect on limitations of prior therapeutic approaches targeting REDD1 in patients, and discuss potential opportunities for future interventions to improve the lives of people living with diabetes. This article is part of a series of Perspectives that report on research funded by the American Diabetes Association Pathway to Stop Diabetes program.

Article Highlights
Glucagon resistance in individuals with obesity and hepatic steatosis can be measured using the GLUSENTIC test and index
Authors: A. S. Kjeldsen Sasha , M. Richter Michael , J. Jensen Nicole , S. D. Nilsson Malin , Heinz Niklas , D. Nybing Janus , H. Linden Frederik , Høgh-Schmidt Erik , P. Boesen Mikael , L. Andersen Thomas , H. Johannesen Helle , A. J. Trammell Samuel , J. Grevengoed Trisha , Madsbad Sten , Vilstrup Hendrik , Vinholt Schiødt Frank , Møller Andreas , B. Rashu Elias , Nørgaard Kirsten , Schmidt Signe , L. Gluud Lise , B. Haugaard Steen , J. Holst Jens , Rungby Jørgen , J. Wewer Albrechtsen Nicolai
Published: July 2024

Increased plasma levels of glucagon (hyperglucagonaemia) promote diabetes development but is also observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This may reflect hepatic glucagon resistance towards amino acid catabolism. A clinical test for measuring glucagon resistance has not been validated. We evaluated our glucagon sensitivity (GLUSENTIC) test, consisting of two study days: a glucagon injection and measurements of plasma amino acids, and an infusion of mixed amino acids and subsequent calculation of the GLUSENTIC index (primary outcome measure) from measurements of glucagon and amino acids. To distinguish glucagon-dependent from insulin-dependent actions on amino acid metabolism, we also studied patients with type 1 diabetes (T1D). The delta-decline in total amino acids was 49% lower in MASLD following exogenous glucagon (p=0.01), and the calculated GLUSENTIC index was 34% lower in MASLD (p<0.0001), but not T1D (p>0.99). In contrast, glucagon-induced glucose increments were similar in controls and MASLD (p=0.41). The GLUSENTIC test and index may be used to measure glucagon resistance in individuals with obesity and MASLD.
XVIII CENTURY AZERBAIJAN HISTORICAL REALITY AND LITERATURE
Authors: Fidan Alizade
Published: July 2024

Throughout the entire history of mankind, literature has been a fact of the time of its creation. When we look at the issue both in a universal context and in a local one, we see approximately the same picture. Just as Homer is a fact of ancient Greece, the work of the genius Azerbaijani poet Nizami Ganjavi of the 12th century is considered to be the fact of the mighty Seljuk Empire, the state of the Atabays of Azerbaijan. Khagani Shirvani's literary heritage, dominated by rebellious and grievous motives, was a literary phenomenon caused by the state of the Shirvanshahs, the Akhsitan dynasty. The invasion of the Mongols, the invasion of Emir Timur, the period-specific manifestations of discontent against oppression and slavery, the spread of philanthropy and the phenomenon of Imadaddin Nasimi.. The work of Alishir Navai, the Uzbek-Chagatai poet and statesman of the 15th century, the author of the first “Khamsa” in Turkic, and the great Turkic culture, which was called the Timurid renaissance, were echoes of Huseyn Baygara's rule which lasted 37 years, in culture, science and literature. The establishment of the Safavid state of Azerbaijan in the XVI century and the fact that Azerbaijan remained the “metropolis and central province of the state” (Efendiyev, 2007: 11) throughout the century, the domestic and foreign policy has had a direct impact on the change of the direction of literature. The biggest event was the stabilization of the tradition of writing in the Azerbaijani language, the preference for the folk language, and the rapid development of ashug poetry. If in the literature of three centuries ago there was a palace splendor, then in the poetry of this period there is already a roar of battlefields, heroic motives surpass love poems, ashug poetry, which is closer to the people, and therefore has a lot of influence and propaganda power. The 18th century Azerbaijani literature is also a “mirror that shows the straight and the crooked” of its time. The article examines the most important events in the history of Azerbaijan of the XVIII century, their influence on the development of literature and features of their reflection in artistic works.
EDUCATIONAL EVENT AS A COMPONENT OF THE SYSTEM OF LANGUAGE TRAINING OF FOREIGN STUDENTS
Authors: Kravchenko Yulia , Gnatenko Svitlana , Tkachenko Valeriia
Published: July 2024

The article discusses one of the aspects of the educational process organized by the Department of Language Training at Zaporizhzhia State Medical and Pharmaceutical University, which faces certain challenges due to psychophysiological and linguistic factors. The former are related to overcoming differences in the sphere of education, requirements and control systems, as well as mastering new social-cultural, educational spaces, and moral-ethical norms of behavior; the latter are due to the complete absence or insufficiency of language training. All these and other problematic issues are in the focus of the tutor during the educational process. These two types of activities are interconnected, as the educational process is aimed at acquiring knowledge, professional skills and abilities, while the upbringing process contributes to the personal improvement of the student. Extracurricular educational activities allow students to improve their knowledge of the Ukrainian language, develop communicative abilities, reveal their inner potential and feel the team spirit. This, in turn, improves the quality of two-way communication between teacher → student and student → teacher.
HARPSICHORD IN THE SOUND PICTURE OF THE XX CENTURY MUSIC, EXEMPLIFIED BY F. POULENC’S СONCERT CHAMPETRE
Authors: Zhukova Olena
Published: July 2024

At the beginning of the XX century harpsichord went through a major revival. The builders’, performers’, and composers’ approach to reconstruction of this instrument and its sound characteristics have created a whole new system of artistic allusions. That system was unexpected in the context of the instrument’s history, yet logical, considering the aesthetic of the time. Original harpsichord pieces of the early–20th-century composers commonly embody mechanical or automatic movements, imitate life of a big industrial city, show evil underworld forces and at the same time allude to baroque aesthetics, the interest to which triggered the revival of the instrument. Paradoxically, the harpsichord in the beginning of XX century is seen as something new and fresh, something able to replace piano, which had already passed its high point. Yet, the harpsichord revival started thanks to the new generation's interest to the music of XVII–XVIII century. Poulenc’s harpsichord concerto, known also as Concert champêtre, written for Wanda Landowska and her unique Pleyel harpsichord, is treated here as one of the brightest examples of the multiplicity of meanings of the harpsichord sound in early 20th century.
CAUSING HARM TO PHARMACEUTICAL ACTIVITY AS AN OBJECT OF CRIMINAL LAW PROTECTION
Authors: Frolova Olena
Published: July 2024

The article is devoted to the issue of causing harm to pharmaceutical activity as an object of criminal law protection. As the author notes, the current legislation regulating the procedure for pharmaceutical activity contains certain guidelines for determining harm to the specified social values or its individual fragments. In the opinion of the author, characterizing the formation of harm "within" pharmaceutical activity as an object of criminal law protection and its consideration in the composition of criminal offenses, it is necessary to determine the types of actions that affect pharmaceutical activity and lead to its violation – formation in it or in certain types of damage to its individual "components". The author consistently proves that the aspects of influence on pharmaceutical activity, which give the committed act the properties of public danger, should be associated with various indicators of damage caused to pharmaceutical activity as an independent object of criminal law protection.
EDUCATIONAL AND PROFESSIONAL PROGRAMS FOR WAR VETERANS AND MEMBERS OF THEIR FAMILIES: ENSURING SUCCESSFUL INTEGRATION INTO UKRAINIAN SOCIETY
Authors: Shechenko Roman
Published: July 2024

The author researched and conducted an analysis that points to the critical importance of developing and implementing effective integration programs for veterans aimed at ensuring their successful transition to civilian life and active participation in society. Aspects including education, professional development, work opportunities, social integration, psychological support and assistance to families are clarified, systematized and analyzed as components of a large and interconnected system. It has been determined that an individualized and flexible approach is critical to the successful integration of veterans, taking into account their unique needs and experiences. It is noted that systemic solutions, especially the involvement of different sectors of society, are seen as successful and adaptive responses to the complex tasks and challenges faced by veterans. The research is substantiated, supporting the need for continuous improvement and adaptation of integration programs to the rapid changes in today's world. The relevance and necessity of developing and implementing comprehensive programs for veterans, which take into account their unique needs and promote full integration into society, are emphasized.
A MODERN PERSPECTIVE ON UNDERSTANDING THE FORMS AND METHODS OF STATE CONTROL IN ECONOMIC ACTIVITIES
Authors: Svitlychnyi Vitalii
Published: July 2024

This article explores the complexities surrounding the modern understanding of the forms and methods of state control in economic activities. It sheds light on the diversity of viewpoints within the scholarly community concerning the interpretation of "form" and "method" in legal terminology, which leads to varied definitions and understandings of how control is implemented through these concepts. The paper notes the presence of two traditional frameworks for distinguishing between forms and methods in scientific discourse, arguing that compiling a comprehensive catalog of forms or methods of control is unfeasible for large-scale systems, such as state oversight in economic matters. It underscores the challenge of delineating the variety of forms and methods of state control and calls for a focused examination of the interplay between these concepts in economic regulation by detailing their key attributes, interactions, and by highlighting the fundamental forms and methods necessary for effective control. The author introduces a novel perspective on the "form" and "method" categories of state control in economic activities, suggesting a fresh approach to organizing these methods.
A RETROSPECTIVE OF PILGRIMAGE LITERATURE AS A COMMUNICATION GUIDE TO THE WORLD OF SACRED CULTURE
Authors: Panchenko Svitlana
Published: July 2024

The purpose of the article is to examine the pilgrimage genre in literature as a social and communication guide in the world of contemporary sacred culture from a communication perspective. Different types of guidebooks are considered, i.e., interviews, travelogues, diaries, records, review texts, memoirs, notes, and pilgrimage travel notes are given as a necessary communication tool during a pilgrimage. The research methodology consists of descriptive (using observation and interpretation techniques), historical and literary, and biographical methods of analyzing pilgrimage literature. The author used the analytical-descriptive method, which consists in the selection, description and analysis of data; the system-structural method helped to arrange the works of different genres and apply them according to the subject in chronological order, reproducing the logical sequence of the material presented. The scientific novelty of the article involves expanding the concept of pilgrimage and the pilgrimage genre in literature as a social and communication guide to the world of contemporary sacred culture based on pilgrimage guides, diaries, memoirs, pilgrimage notes, and other sacred literature. Conclusions. In the article, the author examines the multi-genre works of pilgrimage literature as a communication guide to the sacred world in order to encourage the transformation from a book or a movie to a real pilgrimage for those who have such an opportunity. The article analyzes pilgrimage records, guidebooks, diaries, travelogues, novels, novellas, short stories, and pilgrimage notes to study pilgrimage from a communication perspective for different categories of pilgrims. As a rule, various categories of pilgrims and representatives of different professions go on sacred journeys, and then they write memoirs, pilgrimage texts, songs, scripts for future plays and films, and artists reproduce all details in artworks, and thus pilgrimage penetrates all spheres of an individual’s cultural life, which indicates the highly spiritual component of such journeys. Before going on a pilgrimage, you need to prepare thoroughly, both physically and spiritually, so that guides allow you to follow the trail of others and then plan your sacred journey relatively well. You will never return from a pilgrimage the same as you were before because such travels utterly change the vector of your life. Observing different groups of pilgrims, we can conclude that they all have one thing in common: spiritual enrichment, purification from sins and temptations, and the achievement of catharsis, which will be present in the everyday life of each of us for as long as possible. These works can keep living in ideas for film scripts about pilgrimage, thus expanding their socio-cultural horizons.
EXERCISES AND TESTS IN ENGLISH ACADEMIC WRITING
Authors: Yasynetska Olena
Published: July 2024

The aim of this paper is to disclose the critical domain of academic writing and its pivotal role in scholarly communication and professional achievement. The study seeks to evaluate the efficacy of a structured academic writing approach using a mixed-methods design, incorporating pre-test and post-test assessments alongside qualitative insights derived from the participant feedback. The participants underwent an initial pre-test covering the structural aspects of academic writing, followed by engagement in a structured undergraduate course emphasising specific nuances of academic papers and mastery of cohesive elements for academic and professional purposes. The qualitative aspect provided a nuanced understanding of the learners’ experiences and perceptions. The structured undergraduate course entailed practical activities and tests covering fundamental aspects of academic writing. These encompass understanding the intended audience and purpose, recognising conventions and standards, grasping the subtleties of formal tone and language precision, refining skills in evidence-based argumentation, analysing the organisational structure of academic texts, evaluating the effectiveness of thesis statements, and incorporating tasks related to professional writing. The research underscores the practical application of acquired academic writing skills, aligning them with professional purposes. Overall, the study aims to contribute valuable insights into the effectiveness of a structured academic writing approach in preparing individuals for success in both academic and professional contexts.
POLAND AND UKRAINE: PERSPECTIVE OF INSTITUTIONAL ECONOMICS
Authors: Derkacz Arkadiusz Jan , Bodnaruk Iryna
Published: July 2024

The residential real estate market is one of the most important elements of any economy, based on housing objects that can be owned by different households on certain rights. Identifying all forms and rights of ownership in the housing market of Poland and Ukraine in accordance with the theses of institutional economics and comparing them was the main goal of the study. In our analysis, we want to confirm the hypothesis that the structure of property rights that exists in the residential real estate market and is described in various literature provides only a general description of the real situation. Therefore, the result of our research was the determination that the property rights operating on the housing market in Poland and Ukraine are much more diverse and complex than the five main forms described in the Ostrom model, which is the main basis for defining property rights. This made it possible to identify the existing forms of property rights, in particular for apartments that exist in the analyzed markets, and to establish the distribution of these rights among possible co-owners of these objects.
HR-MANAGEMENT DURING THE WAR: PERSONNEL SUPPORT
Authors: Zubarev Sergey
Published: July 2024

The relevance of the chosen topic is defined in the article. The essence of the concept of HR-management and personnel management is considered. The main differences in the application of HR-management and personnel management are studied. The scientific approaches to consider the elements of the personnel management system are defined. The values of personnel management are considered. The main components of personnel management in war conditions are studied. The functions of personnel management are defined. Challenges that arise in the personnel management system in connection with the beginning of military operations on the territory of Ukraine are considered. The dynamics of changes in the volume of average monthly salaries of employees and the level of unemployment in Ukraine are studied. According to the results of the review of the considered indicators trends changing, it`s possible to confirm that there is a multidirectional change in the average monthly salaries of employees and the unemployment rate in Ukraine. The importance of providing support to personnel who continues to work despite all the difficulties that arise today and may arise in the future is determined. The experience of remote control of the company`s personnel in the war conditions to ensure work efficiency and safety of employees is studied. A set of measures, aimed at supporting personnel in war conditions, are developed. The results of the conducted research are summarized and the prospects for continuing the research on the chosen topic are avaluated.
Pendampingan Organisasi Pemuda Muhammadiyah dalam Penyelenggaraan Kejuaraan Olahraga Tradisional untuk Meningkatkan Warisan Budaya dan Pengembangan Karakter Siswa Sekolah Menengah
Authors: Syaukani Agam Akhmad , Sudarmanto Eko , Fatoni Muhad , Sistiasih Vera Septi , Sulaiman Ahmad , Yulianingsih Ika
Published: July 2024

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk memberikan pendampingan kepada Organisasi Pemuda Muhammadiyah Kowangan dalam penyelenggaraan kejuaraan olahraga tradisional tingkat SMP se-Kabupaten Temanggung. Olahraga tradisional tidak hanya menjadi bagian penting dalam warisan budaya, tetapi juga merupakan sarana efektif untuk mengembangkan karakter dan keterampilan siswa SMP.  Kegiatan ini mencakup tahapan perencanaan, pelaksanaan, dan evaluasi kejuaraan olahraga tradisional. Tim pengabdian memfasilitasi Organisasi Pemuda Muhammadiyah Kowangan dalam menyusun rencana kegiatan, memilih tempat, dan menyusun aturan main yang adil. Selain itu, pendampingan dilakukan melalui workshop untuk meningkatkan keterampilan teknis dan manajerial panitia kejuaraan. Kegiatan ini menghasilkan respon yang positif dari peserta dan jajaran Pengurus Daerah Muhammadiyah (PDM) Temanggung. Secara internal, ketua PCPM menyatakan bahwa banyak manfaat yang diperoleh sepanjang kegiatan pendampingan ini. Selanjutnya, pengetahuan dan keterampilan yang diperoleh PCPM dalam kegiatan ini dapat dimanfaatkan untuk melaksanakan agenda-agenda kerja yang akan datang. Pendampingan yang dilakukan selama 3 bulan memberikan dampak yang signifikan bagi peningkatan kapasitas organisasi PCPM Kowangan. Kegiatan ini dikatakan baru yang pertama kali diikuti oleh PCPM Kowangan. Ke depan diharapkan dapat dimanfaatkan untuk mengoptimalkan agenda kerja yang belum terlaksana agar dapat dilaksanakan dengan baik melalui perencanaan yang matang dan kolaborasi dengan pihak eksternal dengan skim kerja sama sponsorship seperti yang telah dilaksanakan pada kegiatan ini.
CUSTOMER ANXIETY AFTER COVID-19 AND ITS IMPACT TO THE BEHAVIORAL INTENTION AT HYPERMARKET
Authors: Fauziah Fenty , Nardi Nardi , Fitriansyah Fitriansyah , Zien Rushami , Nurfadillah Mursidah
Published: July 2024

The COVID-19 pandemic has significantly impacted the modern retail sector, particularly hypermarkets in East Kalimantan, influencing consumer behavior by creating anxiety and promoting both hedonic and utilitarian shopping behaviors. This study examines how attitudes toward behavior mediate the relationship between anxiety, utilitarian value, hedonic value, and behavioral intention among hypermarket consumers post-pandemic. The study addresses theoretical and empirical inconsistencies in these relationships. Involving 160 participants selected through systematic random sampling, data were analyzed using Partial Least Squares (PLS) with Smart PLS 3.0. Seven hypotheses were tested. Findings indicate that only utilitarian value and attitude toward behavior significantly affect behavioral intention. Both hedonic and utilitarian values predict attitudes toward behavior, while anxiety has a negative and insignificant effect on both behavioral intention and attitudes. Post-pandemic, consumers are no longer anxious about shopping at hypermarkets, suggesting a need for improved promotions and services in hypermarkets.
Polyphenol composition and antioxidant activity of wine raw materials and pomace from hybrid grapes, aronia, and Japanese quince ia melanocarpa) and Japanese quince (Chaenomeles japonica)
Authors: Rätsep Reelika , Maante-Kuljus Mariana , Karp Kadri , Kaldmäe Hedi , Põldma Priit , Koort Angela , Mainla Leila , Moor Ulvi
Published: July 2024

Wine pomace contains high amounts of bioactive compounds, mainly polyphenols, with varying concentrations depending on multiple factors. This research aimed to determine differences in the content of polyphenols and antioxidant activity of the wine raw materials and pomace of Japanese quince (‘Rasa’), aronia (seedlings), and grape (‘Hasansky Sladky’) and between harvest years (2021, 2022), as well as between fruits and pomace. Pomace from aronia and Japanese quince was obtained after maceration for 5 and 7 days, respectively, while grape pomace was collected on the day of harvest. The polyphenol content of fruits and pomace varied significantly between harvest years. Aronia had the highest total polyphenol content in fruits (989 mg GAE 100 g-1) and pomace (1022 mg GAE 100 g-1), followed by Japanese quince (625 and 722 mg GAE 100 g-1) and grapes (390 and 481 mg GAE 100 g-1). Aronia fruits and pomace had higher antioxidant activity. Compared to the fruits, aronia pomace had less chlorogenic acid and neochlorogenic acid. Flavanols were the main polyphenols in the Japanese quince, showing lower content in the pomace when compared to fruits, except catechin content was higher. The content of anthocyanins and flavonols was higher in the rosé wine pomace than in the fruits of grapes.
Point-of-Care Molecular Testing with tinto rangTM: A Food Grade Safe Fluorophore for Colorimetric LAMP Assays at Low Resource Settings
Authors: Singh Shikha , Shree Suresh Shakthi , Benazir Jahangir Fathima
Published: July 2024

LAMP (loop-mediated isothermal amplification) has proven to be a highly robust, sensitive, and cost-effective method for detecting specific target nucleic acid sequences in a single-tube reaction without the need for sophisticated instruments. Traditionally, pH-sensitive dyes, DNA-binding dyes like Ethidium Bromide(EtBr), and SYBR have been employed to detect amplified products. However, these dyes present several drawbacks, limiting the widespread adoption of LAMP in diagnostic applications. 
To address this limitation, a novel dye called tinto rangTM has been introduced with promising applications in nucleic acid analysis. In this study, we present an evaluation of tinto rangTM's performance in comparison to commercially available dyes commonly used in LAMP assays. One of the unique advantages of tinto rangTM is its capability to facilitate the analysis of amplified nucleic acid products through three distinct methods: visual color change, changes in relative fluorescence, and turbidity.
In addition to assessing tinto rangTM's performance, we also investigated various approaches to tackle the issue of non-specific amplification, which has been a common challenge in LAMP reactions. The experimental results unequivocally demonstrate that tinto rangTM outperforms pH-indicating and other DNA-binding dyes used in LAMP assays, making it a superior alternative. This study paves the way for the broader adoption of tinto rangTM in various applications, including point-of-care diagnostics, disease monitoring, and molecular biology research.
Stress Response and Analgesia During and after Robotic-Assisted Pelvic Exenteration
Authors: Lifanova A. D. , Grazhdankin A. A. , Lutfarakhmanov I. I.
Published: July 2024

Introduction. Thoracic epidural analgesia or thoracic epidural anaesthesia (TEA) and opioid-based intravenous multimodal analgesia (MMA) provide adequate control of perioperative pain, however, comparative data are still to be gathered. Aim. To compare both anesthesia techniques in terms of stress response during and after robotic-assisted pelvic exenteration (PE). Materials and methods. 112 patients were divided into 2 equal groups A level of serum cortisol was measured at induction of anesthesia and in 2, 24, and 48 hours. The efficacy of analgesia was compared using a 10-point numeric pain scale. Analgesic administration and side effects were reported for 1–3 postoperative days. Results. Cortisol levels increased 2 hours after skin incision in the MMA group and only in 24 hours in the TEA group (p < 0.050). Postoperative cortisol levels were significantly lower in the TEA group (p = 0.001). Numeric pain scores were significantly lower in the TEA group (1.7 [1.0–3.2] vs. 2.7 [2.1–4.2]; 1.9 [1.0–3.3] vs. 3.5 [3.5–5.0]; 3.7 [3.0–4.8] vs. 4.2 [3.7–4.7], respectively; p < 0.050). Patients in the TEA group received less opioid administration (4.3 mg vs. 13.9 mg; 7.0 mg vs. 19.9 mg; 10.9 mg vs. 16.5 mg, respectively; p < 0.050). The two groups of patients were detected with no significant difference in the incidence of respiratory depression. Discussion. According to the study results, perioperative stress response was reduced with TEA being added to the anesthesia protocol. Patients in the TEA group received lower doses of analgesics. Both groups produced similar short-term postoperative outcomes. Conclusion. As compared to opioid-based MMA, TEA provided more effective analgesia and similar side effect profiles. Therefore, TEA appears to be an acceptable method for stress response suppression and pain management in patients undergoing robotic-assisted PE.
Circular RNA Expression Profile in Cervical Cancer and Construction of the Circular RNA‑MicroRNA‑Messenger RNA Regulatory Network
Authors: Begliarzade S. A. , Tamrazov R. I. , Musaev E. R. , Wang C.
Published: July 2024

Introduction. Cervical cancer (CC) remains the most common cancer in women worldwide. However, effective and specific biomarkers for the diagnosis and prognosis of cervical cancer are yet to be found. In recent years, the potential of circular RNAs (circRNAs) as new diagnostic, prognostic and therapeutic tools has received much attention. The current study involved an in-depth bioinformatics research to explore the circRNA-microRNA (miRNA)-messenger RNA (mRNA) regulatory network in order to identify important molecular processes and biological pathways supposedly associated with CC. Materials and methods. The study collected data on the expression of circRNA (GSE102686), miRNA (GSE30656) and mRNA of target genes (GSE9750), based on the Gene Expression Omnibus (GEO) database, in squamous cell carcinoma of the cervix samples and normal squamous epithelium of the cervix, dividing them into study and control groups. Protein-protein interaction (PPI), Gene Ontology (GO) analysis, and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed to further understand the function of circRNAs for their target genes. Results. A total of 105 differentially expressed circular RNAs (DECs), 144 differentially expressed microRNAs (DEMs), and 539 differentially expressed target genes (DEGs) were identified for cervical cancer. Concurrently, functional enrichment analysis of GO and KEGG pathways was performed for DEGs. Subsequently, searching databases for circRNA, miRNA and mRNA target genes, as well as PPI network analysis and functional enrichment revealed 3 DECs with significantly high expression levels (hsa_circ_0000745, hsa_circ_0084927 and hsa_circ_0002762), 6 DEMs with reduced expression levels (hsa -miR-145, hsa-miR-876-3p, hsa-miR-1229, hsa-miR-182, hsa-miR-520h and hsa-miR-1252) and 9 key genes such as ANGPT2, COL11A1, MEST, KIF20A, CLN6, FNDC3B, USP18, DLGAP5 and CXCL9, suggesting a potentially significant role in cervical cancer. Conclusion.Understanding the circRNA-miRNA-mRNA regulatory network is of great importance for evaluating the oncogenesis of CC, as well as discoverying new circRNAs as the main regulatory molecules in this network. This is considered to be a new direction in the diagnosis and targeted therapy of cervical cancer.
Raman Spectroscopy in Optical Non-Invasive Diagnostics of Skin Neoplasms
Authors: Kaganov O. I. , Loginova I. G. , Moryatov A. A. , Kozlov S. V. , Orlov A. E. , Bratchenko I. A. , Dzhuraev B. B.
Published: July 2024

Introduction. Recent decades indicate a significant increase in the incidence of skin cancer. Aim. To upgrade the specialized device and to improve the quality of skin neoplasm diagnostics. Materials and methods. The study mainly involved the method of non-invasive differential diagnostics of skin neoplasms. The method relies upon optical research methods, including Raman spectroscopy, a spectroscopic technique. A 10-year study, conducted by the Department of Oncology, the Samara Regional Clinical Oncology Dispensary (SOKOD), included more than 500 observations. The study used samples of various skin neoplasms obtained during surgical treatment of patients. Experimental tests provided a certain spectrum of various benign and malignant human skin neoplasms, including melanoma. Results. A series of experimental tests resulted in an experimental setup that is absolutely safe to use. Discussion. The study involved comparison of individual characteristics of the Raman spectra, obtained in the examination of neoplasm and healthy skin for each patient, thereby individualizing the method. The study revealed a high accuracy rate of 92% (with sensitivity of 89%, specificity of 93%), thus minimizing risks of false negative results, which is essential for mass examination. Conclusion. Since the proposed device setup does not require consumable products and different reagents, the method is marked with lower time costs and maintenance burden. Raman spectroscopy obtains a significant potential, thus, can be widely used for skin neoplasms in various medical and preventive institutions.
Mechanisms of Spinal Metastases: New Perspectives
Authors: Beylerli O. A. , Gareev I. F. , Pavlov V. N. , Musaev E. R. , Chmutin G. E. , Wang C.
Published: July 2024

Metastases are considered to be a key mechanism for the spread of malignant tumors, whereby tumor cells separate from the primary site and form new tumor nodes in various parts of the body. Bone tissue, including the spine, is often affected by metastases, which can significantly worsen the prognosis and quality of life of patients. Metastasis comprises a complex multistep process during which tumor cells undergo molecular and phenotypic changes enabling them to migrate and adapt to new conditions in the body. Bone metastases can be osteolytic, causing bone destruction, or osteoblastic, stimulating excessive bone formation. Tumor cells enter the bone and activate osteoclasts or osteoblasts, thereby leading to remodelling of bone tissue and formation of a closed cycle of bone destruction and tumor growth. The characteristics of tumor cells are determined by their genetic and epigenetic changes, as well as interaction with the environment. Understanding the molecular and pathophysiological aspects of spinal metastasis is essential to developing effective treatments and improving therapeutic approaches. The paper considers new therapeutic approaches aimed at overcoming spinal metastasis in order to improve the prognosis and quality of life of patients.
SISTEM DIAGNOSIS PENYAKIT PERNAPASAN (ISPA) MENGGUNAKAN SWI-PROLOG
Authors: Wulandari Ika Arthalia , Mujito Mujito
Published: July 2024

Infeksi Saluran Pernapasan Akut (ISPA) adalah infeksi yang menyerang saluran pernapasan yang disebabkan virus. Berdasarkan hasil wawancara dan observasi yang dilakukan di Puskesmas salah satu Desa Lampung Timur, penyakit ISPA merupakan salah penyakit yang sering terjadi di Desa tersebut sepanjang tahun 2023 terbukti dari akhir tahun 2022 terdapat kurang lebih 20 anak yang terkena penyakit ISPA meningkat menjadi 30 anak di tahun 2023. Metode forward chaining merupakan salah satu metode yang dapat digunakan dalam untuk melakukan diagnosis Penyakit Infeksi Saluran Pernafasan Akut (ISPA). Sehingga dapat membantu orangtua dalam melakukan deteksi dini terhadap penyakit infeksi saluran pernafasan pada anak sehingga penanganan terhadap penyakit tersebut dapat dilakukan secepat mungkin dan dilakukan penanganan awal secepat mungkin untuk mencegah kondisi semakin memburuk. Berdasarkan hasil penelitian yang dilakukan, metode Forward Chaining berhasil memberikan rekomendasi penyakit yang dideritanya
SISTEM INFORMASI PENGELOLAAN ARSIP SURAT BERBASIS WEB PADA BADAN KESBANGPOL
Authors: Irawan Dedi , Asmanto Budi , Puspita Frica Nanda
Published: July 2024

Pengarsipan surat adalah proses kegiatan membuat, mencatat, dan mengarsipkan semua jenis surat baik itu surat masuk maupun surat keluar dalam sebuah instansi. Pada saat ini, prosedur yang diterapkan pada pengelolaan surat masuk dan surat keluar pada Badan Kesatuan Bangsa dan Politik Kota Metro dari mulai pembuatan, penerimaan, dan penyimpanan surat masih dilakukan secara manual. Adanya sistem informasi pengelolaan arsip surat dapat membantu mengurangi terjadinya kesulitan serta waktu yang dihabiskan untuk proses pencarian data surat lebih aman dan efektif, dan memperbaiki pengelolaan pengarsipan surat yang sudah ada.  Sistem informasi yang akan dibuat berbasis web, yang menggunakan bahasa pemrograman PHP MySQL yaitu database yang digunakan, framework yang digunakan adalah Codeigniter versi 3.1.9, Editor pembuatan program menggunakan Sublime Text 3 dan Google Chrome sebagai web browser. Pada penelitian ini didapatkan hasil yaitu sistem informasi yang dapat mengelola arsip surat masuk dan surat keluar yang sesuai dengan alur yang diterapkan, dan dapat menyelesaikan masalah yang ada saat ini.
The Body and the Gallery: Cross Exhibition Review of Sarah Lucas: HAPPY GAS, Women in Revolt!, and If Not Now, When?
Authors: Atkinson Nicole
Published: July 2024

From autumn 2023 to spring 2024, several of London's galleries showcased the works of contemporary women artists, including Sarah Lucas and Helen Chadwick. This review critically examines three key exhibitions: Women in Revolt! and Sarah Lucas: HAPPY GAS at Tate Britain, and If Not Now, When? at Saatchi Gallery’s Season on Sculpture. As the exhibitions highlight themes of identity, resilience, and empowerment, particularly focusing on the female body as a powerful medium of expression, this review explores how women artists utilise the female body in contemporary art as a form of resistance against traditionally repressive, male-dominated art practices. The female body, a common feature in feminist art, is often used as a symbol of rebellion, with artists asserting control and autonomy over their bodies through their work. By occupying these contemporary art spaces, these artists affirm their positions within both the public sphere and the broader art discourse. This cross-exhibition review delves into the current renaissance of the gallery space as a site of resistance, examining its contributions to wider feminist discourses and art practices.
KREATIVITAS PESERTA DIDIK DALAM PEMANFAATAN BARANG BEKAS SEBAGAI MEDIA PEMBELAJARAN ILMU PENGETAHUAN ALAM (IPA) DI SD INPRES WATUBOSE
Authors: Faradilah Faradilah , Rusdin  , Irawan Hadi Patanggu
Published: July 2024

This research was motivated by the creativity of students in using used goods as a medium for learning Natural Sciences (Science) at SD Inpres Watubose. This research starts from the problem of how students are creative in using used goods in science learning and what types of creativity are produced through the use of used goods as a science learning medium at SD Inpres Watubose. This research uses a qualitative approach. Data collection techniques through observation, interviews and documentation. The data analysis technique used is by analyzing data in the form of qualitative data and then interpreting it using an inductive mindset, namely a way of thinking that starts from specific facts, concrete events from research, then drawing generalizations through general characteristics. And the presentation of the data used is to present the data that has been collected in a simpler form. From the results of this research it was found that: 1) implementing activities to utilize used goods as a learning medium at SD Inpres Watubose can foster creativity in students and students can manage used goods so that they can be reused 2) In activities utilizing used goods carried out in schools there are Several types of learning media are produced through students' creativity, including: human breathing apparatus, hand joint movement props and sound sources. All learning media are made by reusing used goods.
Influence of compression ratio on the performance characteristics of a spark ignition engine
Authors: A. Raji Nurudeen ,   Department of Mechanical Engineering, Lagos State University, Ojo (Main campus), Lagos State, Nigeria, O. Kuku Rafiu , O. Openibo Adeshola , A. Owolabi Emmanuel ,   Department of Mechanical Engineering, Lagos State University, Ojo (Main campus), Lagos State, Nigeria,   Transport and Commuter Services, Lagos State Ministry of Transportation, Nigeria,   Department of Mechanical Engineering, Lagos State University, Ojo (Main campus), Lagos State, Nigeria
Published: July 2024

In this study, the influence of the compression ratio on the performance characteristics of a gasoline engine was investigated in detail using COMSOL simulations. Four compression ratios — 8, 9, 10 and 11 — were investigated at different engine speeds between 1000 and 1800. The analysis focused on power output, braking performance and fuel consumption in order to decipher the complicated relationships between compression ratios and engine dynamics. The results showed a significant increase in power output with increasing compression ratio, highlighting the delicate balance required for optimal power generation. Braking power increased with higher compression ratios, indicating a potential improvement in braking performance. In addition, the study showed a correlation between increased fuel consumption and higher compression ratios, highlighting the need for strategic fuel-saving measures. These results contribute to the understanding of gasoline engine behavior and provide insights into the trade-offs that need to be made when adjusting the compression ratio. Recommendations include experimental validation, exploration of dynamic compression control, research into integrated braking systems, investigation of sustainable fuel strategies and a focus on multi-metric optimization. The observed increase in power output at higher compression ratios highlights an important aspect of engine optimization. Engineers and researchers need to carefully consider compression ratio adjustments to ensure optimal power generation while maintaining efficiency. This insight can guide the development of engines that strike an ideal balance between power and fuel efficiency.