bluuebunny/crossref_metadata_2025 huggingface dataset:
Efecto de la suplementación de fisetina vs el ejercicio aeróbico en los niveles de peroxidación lipídica en el cerebro de ratas con diabetes
Authors: Franco Guerra Nora Camila , Arriaga Sánchez Andrea Estefanía , Obregón Vázquez Amalia Ximena , Lara Moreno Rodrigo , Loera López Juan Carlos , Sánchez Briones Luis Alberto , Vera Delgado Karla Susana , Sánchez Duarte Elizabeth
Published: January 2025

La diabetes se caracteriza por cuadros de hiperglucemia crónica, la cual condiciona la aparición del estrés oxidativo (EO), que es responsable de muchas de las complicaciones de esta enfermedad. La peroxidación lipídica es un importante biomarcador de EO debido a su toxicidad y a su capacidad para alterar otras macromoléculas, lo que provoca daño celular. En la diabetes, el cerebro es susceptible al daño oxidativo por su alta tasa de consumo de oxígeno, su abundante contenido de lípidos y relativa escasez de enzimas antioxidantes. La fisetina es un flavonoide que se encuentra en diversas frutas y verduras que ha demostrado tener efectos antiinflamatorios y antioxidantes. Además, el ejercicio físico también se considera una estrategia no farmacológica importante para prevenir y/o atenuar las alteraciones celulares inducidas por el EO. El presente estudio evaluó de manera comparativa los efectos de la suplementación con fisetina y del ejercicio aeróbico de intensidad moderada sobre los niveles de peroxidación lipídica en el cerebro de ratas con diabetes. Se utilizaron 16 ratas macho de la cepa Wistar, las cuales fueron separadas en 4 grupos (n=4): control sano (Ctl), diabetes (D), diabetes con fisetina (D+Fis) y diabetes con ejercicio aeróbico de intensidad moderada (D+EA). La diabetes fue inducida con una dosis única de estreptozotocina (65 mg/kg). Las ratas de los grupos D+Fis y D+EA fueron sometidas a 8 semanas de tratamiento y entrenamiento físico, respectivamente. Al finalizar, se determinó la peroxidación lipídica en el cerebro, mediante la cuantificación de las sustancias reactivas al ácido tiobarbitúrico (TBARS). Los resultados mostraron que los niveles de TBARS aumentaron de manera significativa en las ratas del grupo D en comparación al grupo Ctl (p<0.05). En cambio, los niveles de TBARS disminuyeron significativamente en el grupo D+EA (p<0.05), mientras que en el grupo D+Fis la diferencia no fue significativa con respecto al grupo D. Estos hallazgos implican que el ejercicio aeróbico, como terapia antioxidante, es más benéfico que la fisetina para reducir la peroxidación lipídica en el cerebro durante la diabetes.
Reverberation Time and Musical Emotion in Recorded Music Listening
Authors: Wilkie Hannah , Harrison Peter
Published: January 2025

The influence of room acoustic parameters on musical emotion has to a degree been studied musicologically and empirically. However, there remain large gaps related to limitations in emotion measures and aspects of acoustic setting, with various iterations of digital acoustic reproduction represented in research. This psychological study explores the ways in which systematic alterations to reverberation time (RT) may influence the emotional experience of music listening over headphones. A quantitative approach was adopted, whereby musical stimuli with parametrically altered RTs were heard over user headphones. These were compared for domain-specific musical emotions on the Geneva Emotional Music Scale (GEMS). The main findings showed that the RTs and related acoustic features did not have a strong effect on “Unease” or “Vitality” components of the GEMS, but rather longer RTs had a significant positive effect on aspects of “Sublimity” (i.e., “Nostalgia,” “Transcendence,” “Wonder”). These results suggest that subjective percepts beyond pleasantness or emotional impact are affected by reverberation-based manipulations to room acoustic sound. The study outcomes have particular relevance to recorded music with artificial reverberation, and create scope for complex interactions between reverberation time and emotion more broadly.
In Memoriam Professor Kęstutis Nastopka (1940–2024)
Authors: Satkauskytė Dalia
Published: January 2025

-
Впровадження європейських принципів відкритої науки в Національній академії наук України
Authors: Загородній Анатолій Глібович , Хіміч Олександр Миколайович , Андон Пилип Іларіонович , Дубровіна Любов Андріївна , Радченко Анна Ігорівна , Жук Олександр Михайлович , Діденко Юлія Володимирівна , Свістунов Сергій Якович , Шадура Віталій Миколайович , Тульчинський Вадим Григорович , Горбачук Василь Михайлович , Ніколаєвська Олена Анатоліївна , Коломієць Олександр Вікторович , Гарагуля Сергій Сергійович , Симоненко Тетяна Василівна , Заїка Віктор Миколайович , Новицький Олександр Вадимович , Проскудіна Галина Юріївна , Резніченко Валерій Анатолійович , Капіца Юрій Михайлович , Черновська Світлана Миколаївна , Шахбазян Карина Суренівна
Published: January 2025

У статті наведено результати діяльності з впровадження в НАН України європейських принципів відкритої науки — нового підходу до організації наукового процесу на основі поширення знань з використанням цифрових технологій і нових засобів спільної роботи дослідників. Побудована в НАН України централізована інфраструктура відкритої науки сприятиме підвищенню продуктивності наукових досліджень, глибшій інтеграції українських вчених у європейський дослідницький простір, ефективнішому пропагуванню отриманих науковцями НАН України наукових результатів і ширшому залученню міжнародних грантів.
Зміни НАН України в контексті сучасних реалій
Authors: Тимоха Олександр Миколайович
Published: January 2025

У виступі перелічено основні проблеми, які сьогодні постають перед науковою сферою в Україні і пов’язані з масовою еміграцією науковців, зникненням низки критично важливих наукових напрямів, скороченням годин на викладання природничих і технічних дисциплін у шкільних програмах тощо. Наголошено на необхідності створення наукових «інкубаторів», які б стали прикладами ефективного залучення іноземної допомоги і поліпшення ситуації з кадровим потенціалом. Зазначено, що Академія має брати більш активну участь у формуванні освітньої політики держави.
El uso de anticuerpos monoclonales en dermatología
Authors: Castrillón Rivera Laura Estela , Palma Ramos Alejandro , Castañeda Sánchez Jorge Ismael
Published: January 2025

Introducción: La participación de los componentes inmunitarios en las patologías inflamatorias de la piel ha traído como consecuencia la posibilidad de intervenir en los procesos que las desencadenan o perpetúan, de ahí la importancia de conocer las diversas terapias biológicas que tienen como blanco, proteínas específicas que son el resultado de la disfunción de la respuesta inmune en varias enfermedades de la piel. En el presente trabajo de revisión, se presentan diversos aspectos relacionados con el criterio de selección de los productos biológicos (o biofarmacéuticos) con particular interés en los anticuerpos monoclonales (mAb) así como las principales patologías dermatológicas en los que se han aplicado. Esto, en virtud de que los mAb se han utilizado mayormente en la terapéutica de neoplasias y se explora la posibilidad de su uso en otros padecimientos de la piel además del cáncer. Desarrollo del tema: La presente revisión bibliográfica aborda los principales aspectos relacionados con: a) Seguridad e inmunogenicidad de los anticuerpos monoclonales, b) Aplicaciones terapéuticas de los mAb en dermatología: Psoriasis, Dermatitis atópica, Hidrandenigtis supurativa, Urticaria, Pénfigo, Alopecia areata, Pioderma gangrenoso Pitiriasis nubra pilaris, Sarcoidosis cutánea, Síndrome de Behcet y en otras patologías, c) Biosimilares en dermatología y d) Lesiones cutáneas asociadas con el uso de anticuerpos monoclonales. Discusión: La terapéutica basada en mAb es un área de constante crecimiento y la tecnología recombinante ha permitido la obtención de moléculas cada vez más estables y menos inmunogénicas que permitirán ofrecer opciones terapéuticas a varias patologías dermatológicas con características de hiperinflamación o inmunosupresión. Conclusión: El aumento de estudios clínicos para el uso potencial de anticuerpos monoclonales en dermatología permitirán su autorización por las agencias regulatorias y aumentar el arsenal terapéutico para padecimientos de difícil control.
Therapeutic role of medicinal plants against viral diseases focusing on COVID-19: Application of computational chemistry towards drug design
Authors: Mollaamin Fatemeh , Shahriari Sara , Monajjemi Majid
Published: January 2025

Introduction: The phytocompounds of curcumin, epicatechin-gallate, luteolin-7- glucoside, and zingerol extracted from Garlic, Turmeric/Curcuma, Green tea, Welsh onion/Leek, and Ginger, respectively, were studied in this paper. Therefore, the purpose of this research is evaluating the effective physicochemical properties of these herbal products to to fight against the SARS-CoV-2 infection. Materials and Methods: The properties of these phytocompounds including dipole moment, thermochemistry, chemical shielding tensors, charge density, electrostatic potential and electron donating and electron accepting through frontier orbitals have been computed due to density functional theory (DFT) and m062x/cc-pvdz pseudo=CEP method towards the drug delivery system. Results and Discussion: T hermochemical properties have evaluated the combined group contribution and atom connectivity index with uncertainties in the estimated property values. The minimum Gibbs free energy of –1014.602×103 and –990.992×103 kcal·mol-1 for luteolin-7-glucoside and epicatechin-gallate, respectively, has been calculated versus dipole moment, which can indicate the most stability of these structures as natural antiviral medications. In fact, it can be established how phytocompounds of allicin, curcumin, epicatechin-gallate, luteolin-7- glucoside, and zingerol extracted from Garlic, Turmeric/Curcuma, Green tea, Welsh onion/Leek, and Ginger, respectively, may act as the efficient antiviral of Coronavirus disease receptor. The NMR analysis has demonstrated the critical points of the principal components of medicinal plants for binding to the active site of TMH (Tyr160-Met-161-Hi162) COVID-19, while each active atom of O or N as the electronegative atoms for binding to the H remarks the maximal shift in all steps in the NMR spectrum. Moreover, UV–VIS spectra reported a positive induction of antioxidant compounds, such as polyphenols and f lavonoids. Conclusions: Thus, these natural drugs may be either a new or safe treatment or even are employed as antiviral nutraceuticals in elevating immunity and producing endurance to virus infections.
The theoretical description for cobalt oxyhydroxide-assisted resveratrol electrochemical determination in vines and juices
Authors: Tkach Volodymyr V. , Kushnir Marta V. , Storoshchuk Nataliia M. , Luganska Olga V. , Kopiika Vira V. , Novosad Nataliia V. , Lukanova Svitlana M. , Ivanushko Yana G. , Ostapchuk Valentyna G. , Melnychuk Svitlana P. , Yagodynets Petro I. , De Oliveira Sílvio C. , Ferrão de Paiva Martins José I. , O´Neill de Mascarenhas Gaivão Isabel , Monteiro Maria João , Kormosh Zholt O. , Garcia Jarem R. , Da Silva Filho Eloi A. , Vitriak Oksana P.
Published: January 2025

Introduction: The possibility of resveratrol electrochemical determination, assisted by cobalt (III) oxyhydroxide and its composites with conducting polymers has been evaluated from the theoretical point of view. Methodology: The correspondent mathematical model has been developed and analyzed by means of the linear stability theory and bifurcation analysis. Results: The analysis of the model confirms that the cobalto oxyhydroxide may serve as an efficient electrode modifier for resveratrol electroanalytical determination. Conclusion: Depending on the analysis conditions, the electroanalytical process may be either diffusion- or kinetically controlled. On the other hand, the oscillatory behavior is also possible being even more probable than in the simplest cases, due to the impact of the chemical and electrochemical stages on DEL.
Inhibitory effect of the essential oil of Schinus molle L. against pathogens causing periodontal disease
Authors: Cadena-Viteri Carlos , Lima-Illescas Miriam , Pacheco-Quito Edisson-Mauricio , Balseca-Ibarra Mariela Cumandá , Sacoto-Figueroa Fernanda , Cuenca-León Katherine
Published: January 2025

Introduction: There are several oral diseases caused by various microorganisms. In this work, we discuss periodontal pathogens, which cause chronic degenerative damage in the supporting tissues of teeth. This is why several treatments have been developed for their eradication, including phytocomponents and essential oils as an option in antimicrobial therapy. Objective: The aim of this study was to determine the inhibitory effect of the essential oil of the plant species Schinus molle L. native to Ecuador on strain of Porphyromonas gingivalis at different concentrations. Methodology: This was a laboratory and longitudinal study in which the Porphyromonas gingivalis ATCC 33277 strain was cultured in 20 Petri dishes, working with several exposure subgroups, including Group 1 - 50% essential oil of Schinus molle leaves; Group 2 - 100% essential oil of Schinus molle L.; Group 3 - 0.12% chlorhexidine (positive control); Group 4 - saline solution (negative control) with different incubation periods of 24 and 72 hours. Results: The Porphyromonas gingivalis ATCC 33277 sample exposed to 100% plant species Schinus molle L. for 24 hours had an inhibition zone of 15 mm, demonstrating high sensitivity, and exposure for 72 hours produced a zone of 14 mm, also suggesting sensitivity. Exposure to S. molle L. at 50% for 24 hours produced a zone of inhibition of 9.65 mm, showing sensitivity; however, it is worthwhile to continue developing and evaluating this area of study. Conclusions: This study demonstrates that phytotherapy using the essential oil of the plant species Schinus molle L. represents a therapeutic option in cases of infections caused by Porphyromonas gingivalis.
New results regarding the existence, uniqueness and convergence of the solution for nonlinear fractional Volterra integro-differential equations via Caputo-Fabrizio operator
Authors: Guechi Moufida , Khalouta Ali
Published: January 2025

In this paper, we study new results regarding the existence, uniqueness and convergence of the solution of nonlinear fractional Volterra integrodifferential equations via Caputo-Fabrizio operator. The main results of this paper are based on the Banach contraction principle. Furthermore, we investigate the approximate analytical solutions of the proposed problem using a new combination method called Khalouta decomposition method. Some illustrated examples of our results are provided with some numerical simulations of the solutions.
Cambios e hibridaciones en los hábitos y gustos alimentarios de las familias inmigrantes en espacios urbanos marginales de Culiacán, Sinaloa
Authors: Acosta Moreno Gladis Zulema , Cota Elizalde Beatriz Delia
Published: January 2025

La migración, como fenómeno social y cultural en México y, de forma particular, en la zona geográfica del valle de Culiacán, Sinaloa, se expresa en los cambios alimentarios de las familias inmigrantes que se establecen en un nuevo contexto cotidiano. Esto se refleja en los hábitos alimentarios adquiridos mediante algunos condicionantes sociales, como el gusto, la disponibilidad alimentaria y el ingreso salarial. De este modo, siendo la alimentación inmigrante un tema prioritario para las políticas de asistencia alimentaria y de salud, se presenta un estudio mixto, predominantemente cualitativo, con la aplicación de 15 entrevistas semiestructuradas dirigidas a las madres de familia y una encuesta sobre hábitos alimentarios y datos sociodemográficos aplicada a 103 familias inmigrantes establecidas en la Sindicatura de Aguaruto de Culiacán, Sinaloa, con el objetivo de analizar los hábitos alimentarios adquiridos en su nuevo espacio geográfico y de revelar patrones de consumo alimentarios de la población inmigrante establecida en espacios urbanos marginales. Los resultados apuntan a una hibridación en la cultura alimentaria construida en los nuevos espacios donde se establecen, reflejada en gustos, hábitos alimentarios y patrones de consumo combinados con alimentos del lugar de origen y alimentos regionales, así como la tendencia a preferir alimentos industrializados, condicionados por el ingreso económico, el gusto y la disponibilidad alimentaria de la región, elementos que han constituido el habitus alimentario construido en los nuevos espacios de asentamiento.
Subjetividades disonantes: experiencias vividas en la práctica del Trabajo Social desde la perspectiva de la disidencia sexual y de género en Cartagena de Indiasdisonantes. Experiencias vividas en torno a la praxis del trabajo social en perspectiva de disidencia sexual y de género en Cartagena de Indias
Authors: Pérez Alvárez Alexander
Published: January 2025

Este artículo analiza experiencias en la intervención social de trabajadoras sociales en Cartagena desde la perspectiva de la disidencia sexual y de género. Con un grupo de profesionales egresadas del programa de Trabajo Social de la Universidad de Cartagena se busca identificar influencias socioculturales, develar mediaciones y resistencias y reflexionar sobre cómo el contexto heteropatriarcal contribuye a la reproducción o a la problematización de discursos hegemónicos en la intervención profesional. Romper con la lógica binaria y de subordinación permite reconocer formas de expresión de los cuerpos, los deseos y posibilita hablar de disidencias sexuales, entendidas como una categoría dinámica que desafía el orden heteronormativo en la sociedad y desde la cual es importante replantear la praxis del Trabajo Social para asegurar una intervención más disonante, emancipadora y transformadora.
Construcción social, vínculos intersubjetivos y sujetos situados: el caso de los “escuadrones de la muerte” en las calles del sur de Veracruz, México
Authors: Jimémez-Herrera Julio
Published: January 2025

El presente estudio se interna en el mundo subjetivo y cotidiano de un grupo de sujetos que se caracterizan por vivir y beber en las calles de la región sur de Veracruz - México, culturalmente conocidos como escuadrones de la muerte. Desde la perspectiva metodológica, con abordaje cualitativo, de corte comprensivo-narrativo, se apuntala en los supuestos del construccionismo social, se implementa una estrategia de amistad y se aplican entrevistas no estructuradas. Los resultados revelan que el contexto y el grupo de individuos brindan mayor solidaridad, afecto y cohesión que las familias de origen, al compartir sus historias con sus iguales, lo cual hace que se vinculen intersubjetivamente y, en consecuencia, persistan en las calles.
La transcendencia de la escritura en el entorno digital universitario
Authors: Rossette García Javier , Martínez Gabriela Clemente
Published: January 2025

Desarrollado bajo técnica documental, el presente manuscrito tiene como finalidad exponer los argumentos de la comunidad científica sobre el acto comunicativo escrito, así como su trascendencia global al difundirse a través de los dispositivos electrónicos en formato digital. Esto conlleva al planteamiento de posturas a favor y en contra de este fenómeno, donde el análisis pone énfasis tanto en las opiniones a favor de la escritura manual (texto analógico) y quienes están a favor de la escritura electrónica (texto digitalizado). De ahí que, profesores y profesoras tienen que advertir el papel que juegan los nuevos entornos de aprendizaje, saber utilizarlos y, a su vez, crear una conciencia axiológica en el estudiantado, sobre la importancia del uso normativo de la lengua que, bajo cualquier circunstancia o contexto, lleva implícita un valor histórico-social perenne.
Potential of artificial intelligence and search engines to successful passing the test part of primary accreditation and primary specialized accreditation
Authors: Zheleznova E. A. , Vlasov V. V. , Vlasova A. V. , Depui T. I. , Podobed I. V.
Published: January 2025

ChatGPT is a language model that has many benefits and applications in healthcare and medicine. It can be useful for medical professionals in various fields, including research, diagnostics, patient monitoring, and education. However, the use of GPT chat also entails a number of ethical issues and limitations, such as accuracy, plagiarism, copyright infringement and bias.

The study aim was to assess the potential of passing primary accreditation and primary specialized accreditation using artificial intelligence — ChatGPT, and the Yandex search engine.

The study consisted of 2 stages. The study revealed that using ChatGPT made it possible to pass General Medicine primary accreditation and Cardiology primary specialized accreditation. Using ChatGPT4 significantly accelerated the test. However, despite the significant acceleration of artificial intelligence, the quality of the answers does not allow successful accreditation in all specialties. A tendency was noted that the subjects began to trust the bot's answers to a greater extent without checking it.
Implementing the Kids’ Athletics Program in the System of Increasing the Level of Physical Performance of Youth
Authors: Jakubík Ján , Broďáni Jaroslav
Published: January 2025

Objectives. The objective of this study was to verify the impact of the IAAF project “Kids’ Athletics” on the physical performance of pupils in primary education through the design and implementation of an athletics program.
Materials and methods. The present study was conducted using a two-group non-concurrent experiment, in which the experimental group (decimal age 8.64 years) consisted of 50 probands and the control group (decimal age 8.55 years) consisted of 60 probands aged 8-9 years. Additionally, 8 physical abilities tests were used to obtain selected indicators of the level of motor performance and probands’ skill. The effectiveness of the 7-month experimental program was evaluated using comparative analysis through non-parametric statistical methods: Wilcoxon and Mann-Whitney U test and substantive significance assessment: Cohen (r). The difference in the progress of both samples was also determined. 
Results. From a total of 8 motor tests in the experimental sample, a progress was observed in all 8 cases, of which the following changes were significant in 6 tests: Movement Set with Bar (z = 3.84, p < 0.00, r = 0 .54), Static Pull‑Up Hold (z = 3.53, p = 0.00, r < 0.50), Sit-Up (z = 5.29, p < 0.00, r = 0.75), 3-Way Ball Rolling (z = 4.31, p < 0.01, r = 0.61), the 4×10m Shuttle Run (z = 4.20 m, p < 0.01, r = 0.59) and the Beep Test (z = 4.64, p < 0.01, r = 0.66). In the case of the control group, there was a progress at the level of statistical significance in the Sit-Up (z = 2.87, p < 0.01, r = 0.37), in the 4×10 m Shuttle Run (z = 4.94, p <0.01, r = 0.64) and the Beep Test (z = 2.98, p<0.01, r = 0.38). 
Conclusions. It has been proven that the “Kids’ Athletics” program, composed of selected disciplines of Kids’ Athletics supplemented by athletic movement games, has a significant impact on a wider range of physical abilities in 8- to 9-year-old children compared to the traditional content of the ISCED 1 state education program. Based on the findings of this study, as well as the comparison of other research works devoted to related issues, it is pointed out the feasibility of implementing such an athletic program into the annual timetables of Physical Education and Sports in primary education at this particular age period.
Open Field Behavior in Mice v1
Authors: Sun Yue , H. Roth Richard , Hwang Fuu-Jiun , B. Ding Jun
Published: January 2025

The open field test is widely used to assess spontaneous locomotor activity, exploratory behavior, and anxiety-like responses in rodents.
Modified CTAB procedure for extraction of plant DNA from bird feces v1
Authors: Motta Carina , Marciano de Godoy Vinicius , Corrêa Côrtes Marina
Published: January 2025

Modified CTAB procedure to extract plant DNA from bird feces stored in alcohol. Final concentration of the 2% CTAB solution include the following: CTAB, NaCl, EDTA, Tris-HCl (pH 8.0), PVP (40). We recommend making a new batch of CTAB solution before each extraction. Modifications include an increased lysis time (up to 12 hours), as well as the use of sodium acetate ( ) and NaCl ( ) in the wash step. DNA acquired is suitable for PCR.
[RETRACTED] Fracionamento de Extratos de Cianobactérias em Manifold Utilizando a Resina Diaion HP20-SS v2
Authors: Pereira de Jesus Rômulo , Manoel Crnkovic Camila , M. Borges Ricardo
Published: January 2025

[RETRACTED]

This protocol presents a detailed method for the fractionation of extracts using the Diaion HP20-SS resin, a version of DIAIONTM HP20 with smaller particles, made of porous polystyrene/divinylbenzene. The procedure includes steps for extract preparation, column packing, extract addition, and fraction collection using different proportions of isopropanol (IPA).
Tamoxifen Administration in Transgenic Mice v1
Authors: Sun Yue , H. Roth Richard , Hwang Fuu-Jiun , B. Ding Jun
Published: January 2025

This protocol describes the procedure for inducing CreER-mediated recombination at loxP sites in transgenic mice through the administration of tamoxifen or 4-hydroxytamoxifen (4-OHT). 4-OHT is the active metabolite of tamoxifen and directly binds to the estrogen receptor (ER) domain of CreERT2. Therefore, tamoxifen is preferred for systemic or long-term in vivo induction due to its stability, whereas 4-OHT enables more precise and rapid Cre activation but is less stable and requires careful handling.
Collective Identity and Care Ethics: Insights From Chilean Migrant Solidarity Initiatives
Authors: Hernández Araya Tamara
Published: January 2025

Based on ten months of ethnographic fieldwork conducted with more than twelve migrant organizations in Chile, this article examines how mutual support groups establish and maintain networks of care that their members view as moral imperatives. These organizations develop sophisticated citizenship narratives while emphasizing the importance of nurturing both their collective ethos and solidarity initiatives. Through analyzing how members interpret their collaborative care and solidarity efforts, this article reveals how care practices generate a distinctive form of sociability that departs from traditional Chilean solidarity frameworks. This emergent sociability manifests as an ethical project that challenges prevailing paradigms and expands our understanding of citizenship dynamics within migrant communities. The research contributes to anthropological perspectives by illuminating the intricate relationships between care practices, collective identity formation, and human interaction within migrant support networks.
METHODOLOGY FOR IDENTIFYING OPERATING OBJECTS IN OIL FIELD DEVELOPMENT BASED ON MATHEMATICAL AND STATISTICAL INDICATORS (USING THE EXAMPLE OF THE PIRALLAHI (NORTHERN FOLD) FIELD)
Authors:   Azerbaijan State University of Oil and Industry, Baku, Azerbaijan Republic, SULEYMANOVA Vafa , MANSUROVA Samira ,   Azerbaijan State University of Oil and Industry, Baku, Azerbaijan Republic, MAMMADOVA Nazile ,   Azerbaijan State University of Oil and Industry, Baku, Azerbaijan Republic
Published: January 2025

Background. In this research, a table based on samples taken from wells in each of the two horizons and using the formation parameter values was compiled. As a result of the researches, five formation parameters (geological and technological) were included in the matrix, and parametric criteria were used to determine the degree of similarity or difference between the upper and lower layers of the KS.

Methods. In Pirallahi using the actual data of the wells that opened both layers, (CUS and CLS) calculations were made according to statistical indicators based on the values of the relevant indicators and checked with parametric criteria. Since the calculated prices are lower than the table values and there is a similarity between both objects, it is recommended to combine them and operate them together. Such an approach leads to intensification of development.

Results. Due to the examination of complex geological and operational data, the following proposals are recommended along with the consolidation of similar layers in the north of Pirallahi.

Conclusions. Thus, since the geological and production indicators between the objects KSupper and KSlower are almost similar, it is advisable to combine them into one object and exploit one grid of wells. The allocation of such objects leads to the intensification of exploitation, and the results can be used in drawing up projects for the development of such layers.
STRUCTURIZATION OF TECHNOLOGICALLY CHANGED VOLUMES OF THE "PIVDENNYI" QUARRY OF C. KRYVYI RIH
Authors:   State Institution "Institute of Environmental Geochemistry of the National Academy of Sciences of Ukraine", Kyiv, Ukraine, OSMACHKO Liubov , VERKHOVTSEV Valentin ,   State Institution "Institute of Environmental Geochemistry of the National Academy of Sciences of Ukraine", Kyiv, Ukraine
Published: January 2025

Background. The research took place within the "Pivdennyi" iron ore quarry in Kryvyi Rih c. with the aim of comprehensive and effective further use of the technogenically transformed areas of the subsoil and the earth's surface of Kryvbas. A brief overview of the achievements of previous researchers is given.

Methods. Generally accepted research methods are applied. The fixation of bedding elements in relatively undisturbed, small-sized blocks (hereinafter – "blocks" or "surviving block") of quartzites and shales of the Saksagan suite and in blocks of demarcation of surviving block – technogenic accumulations was carried out. In relatively undisturbed blocks of quartzite, such elements for banding, schistosity, linearity of mineral aggregates, axes of folded forms, striation, furrows, etc. were measured. The actual material regarding the placement of structural elements was processed using the StereoNett 2.46 program, and the displacement calculations of the blocks of the studied formations were also made.

Results. Among technogenic accumulations (scree slope, embankments and filled artificial cavities), according to the degree of structuring, unstructured and structured to varying degrees were observed. Layering, mechanical schistosity and linearity are fixed within them. It was found that the formation of the system of blocks of the "Pivdennyi" quarry took place during their rotation along both the vertical and horizontal axes.

Сonclusions. The emergence of newly formed planes of technogenic accumulations took place with the inheritance of the structural anisotropy existing in the surviving block with the creation of its own stratification. Therefore, the investigated system "surviving block – technogenic accumulations" developed and formed as a complete object, mutually coordinated, years – decades in surface conditions. The transformation of technogenic accumulations, their "completion"/structuring, as a result of which the integrity of disturbed and missing areas of the geological volume is restored, are constructive phenomena. They are practically a natural laboratory of processes of formation of structural and textural elements in loose accumulations. Their tracking in time would make it possible to actually observe the processes of self-creation/reproduction of modern technogenic-natural objects. The ranking of structural neo formations in technogenic accumulations can be used as one of the criteria for assessment the assimilation potential of these accumulations and their suitability for economic reclaim.
Applying the ETAS Model to Simulate Earthquake Sequences for Hazard Assessment in Crustal Seismicity Regions with Scarce Data
Authors: Šipčić Nevena , Kohrangi Mohsen , Marzocchi Warner , Bazzurro Paolo
Published: January 2025

Considering earthquake sequences in seismic hazard and risk analyses has become increasingly important. Many sequences around the world demonstrated that limiting the consideration to only mainshocks leads to underestimation of hazard and, more importantly, risk. Among the methods to simulate earthquake sequences, the epidemic-type aftershock sequence (ETAS) model has shown notable accuracy in representing these complex sequences making it a valuable tool for seismic hazard and risk assessment. However, the ETAS model is rather complex and for regional applications it requires many parameters to be calibrated. The calibration is most effective when a long instrumental catalog complete to low-magnitude events is available. However, this is rarely the case. Our study investigates the possibility of using the ETAS model with parameter values calibrated for a region with many recent sequences (namely central Italy) to simulate realistic sequences in two other crustal seismicity regions, namely Türkiye and Croatia. We compare three options (1) using a set of ETAS parameters calibrated based on local data, (2) fixing most ETAS parameters to values derived from a well-studied region with many recent sequences (central Italy) while locally calibrating the total background rate and productivity term (SimplETAS [SE] parameter set, akin to the simplETAS methodology of Mancini and Marzocchi (2023), and (3) fixing all ETAS parameters to values from central Italy except for the total background rate (Set of Central Italy [SCI] parameter set). The results show that simplified approaches based on central Italy data (SE and SCI) can produce simulated earthquake sequences that align well with the observed data even for Croatia and Türkiye. This reflects the applicability of modeling earthquake sequences for hazard and risk applications in many crustal regions where good quality observed instrumental catalogs complete to low-magnitude events are not available or they are available but do not contain significant sequences.
Reseña de: Humanismo y retórica visual, Víctor Mínguez Cornelles, Carmen Morte García y Rafael García Mahíques (dir.) y Teresa Sorolla Romero (coord.), Castellón de la Plana, Publicaciones de la Universitat Jaume I, Biblioteca Potestas n.9, 2024, 663 pp.
Authors: Burgos Martínez Mercedes
Published: January 2025

Reseña del volumen colectivo Humanismo y retórica visual, que incluye treinta y tres trabajos de los presentados en el XIV Congreso Internacional de la Sociedad Española de Emblemática, celebrado en Alcañiz en 2023. Las investigaciones subrayan la importancia de la retórica visual como herramienta de legitimación del poder y su impacto cultural e histórico.
Cervical cerclage for cervical insufficiency: methods and pregnancy outcomes at a tertiary hospital in South-Western Nigeria
Authors: Adebisi Mathew O. , Adekanye Emmanuel A. , Adeniyi Adebayo A. , Afolabi Oluwasesan B. , Okurumeh Ogheneovo I. , Adeyemo Olabisi T. , Adewara Olumide E. , Awoyinka Bbatunde S. , Bakare Adewumi
Published: January 2025

Background: A ‘gold standard’ for the treatment of cervical insufficiency is by inserting cervical cerclage. This intervention may not be successful in all cases. Hence, there is a need to assess the methods and pregnancy outcomes of cervical cerclage, and draw conclusion from the findings.  Objectives were to assess the methods and pregnancy outcome of cervical cerclage in women with cervical incompetence at the federal teaching hospital, Ido-Ekiti, Ekiti State.
Methods: This is a 5-year retrospective review of the records of women that had cervical cerclage between June 2019 and June 2024. The data were retrieved and analyzed for their socio-demographic factors, clinical characteristics, landmark past clinical events, number of past cerclage insertions, and the methods and pregnancy outcomes of index cerclage. The data obtained were analyzed using SPSS version 26.
Results: There were 27 cases of cerclage placement per 2,489 deliveries (1 in 92 births) during the period under review. The mean age was 33.6±4.8 years. Majority (74.1%) aged 31 to 40 years. Two-thirds of women (66.7%) had no prior births, 25.9% had one birth, and 7.4% had two or more births. The McDonald’s technique was the most commonly used method, accounting for 92.6% of cases. Favourable outcome was recorded in 85.2% of the women.
Conclusions: This study showed that majority of the women treated with cerclage had successful pregnancy outcome, further supporting this intervention as a “gold standard” for managing cervical incompetence.
Vitamin B12 deficiency in pregnancy and its association with maternal and fetal outcomes
Authors: Jahan Noor , Fatema Kaniz , Das Tripti Rani , Pervin Hasna Hena , Sharmin Riffat Ara , Majumder Dipika , Islam Fahmida , Tamanna Tabassum , Nessa Meherun
Published: January 2025

Background: Pregnancy is a unique physiological state characterized by profound changes in a woman's body to support fetal growth and development. Adequate nutrition is vital during pregnancy to meet the increased demands of both the mother and the developing fetus. Among the various nutrients required during pregnancy, vitamin B12 stands out as a critical micronutrient. It plays a pivotal role in cellular replication, neurodevelopment, and the synthesis of DNA, making it essential for the proper growth and development of the fetus. This study was conducted to evaluate vitamin B12 deficiency in pregnancy and its association with maternal and fetal outcomes. 
Methods: This was a cross-sectional study conducted among consecutively selected pregnant women who had just given birth to a single live baby admitted to the department of obstetrics and gynecology and also the department of feto-maternal medicine, Bangabandhu Sheikh Mujib medical university (BSMMU), Shahbagh, Dhaka from September 2022 to August 2023. A total of 90 women of 18-40 years of age at their 28-40 weeks of gestation were included in this study. Study subjects with vitamin B12 levels of <200 pg/ml were considered as the low level (group I), whereas level ≥200 pg/ml was considered as the normal (group II). Observations were undertaken on pregnancy complications and perinatal outcomes, which were compared between the two groups.
Results: The study revealed majority (57.8%) of the study participants age were within 26-34 years, a housewife was 74.4% and multigravida constituted 70.0% of the respondents. The 31 (34.4%) of the respondents had vitamin B12 level below 200 pg/mL and 59 (65.60%) women had normal serum vitamin B12 levels (≥200 pg/mL). Congenital hydrocephalus was observed in 16.1% of the group I mothers compared to only 1.7% in group II (p=0.017) and neural tube defect was present in 9.7% of group I but in none of group II mothers (p=0.038). 
Conclusions: Mothers having vitamin B12 deficiency experience significantly higher rates of oligohydramnios, fetal hydrocephalus, and neural tube defects compared to those with normal vitamin B12 levels. However, there was no significant maternal complication.
The effect of letrozole on liver function test in polycystic ovarian syndrome with subfertile patient with and without fatty liver disease
Authors: Sarkar Binita , Akter Fatema , Jikria Najmatun , Sikdar Koushik
Published: January 2025

Background: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder characterized by subfertility, insulin resistance and metabolic dysfunction, commonly associated with nonalcoholic fatty liver disease (NAFLD). Letrozole is a first line ovulation induction agent, superior to clomiphene citrate but liver effects in PCOS patients with and without fatty liver disease has not been sufficiently explored. This study aims to determine the effect of letrozole on liver function tests (LFTs) in subfertile PCOS patients stratified by the presence of fatty liver disease.
Methods: This cross-sectional observational study carried out at department of obstetrics and gynecology, Shaheed Syed Nazrul Islam Medical College Hospital, Kishoreganj, Bangladesh from 1st October 2023 to 31st of March 2024. The study included 150 subfertile women with PCOS who had been divided equally between groups with or without fatty liver disease. The baseline characteristics, metabolic profiles and LFT parameters were analyzed.
Results: Across both groups, letrozole improved ovulation and pregnancy rates, but the patients with fatty liver disease had markedly increased LFT parameters compared to those without, for example (ALT: 39±7.9 versus 25.5±6.4 U/l; p<0.001). Fatty liver group also had worse metabolic markers. In patients with fatty liver, 20% of patients developed adverse liver effects.
Conclusions: Letrozole is effective for ovulation induction in subfertile PCOS patients but is hepatotoxic particularly if the patient has associated fatty liver disease. In high risk groups, therapists should closely monitor liver function.
Various presentations of gestational trophoblastic disease and its outcomes in a tertiary hospital
Authors: Begum Monowara , Khan Sadia Jabeen , Begum Shirin Akter , Khatun Sayada Fatema , Akter Nasrin , Khanom Suriya , Un-Nabi Mahmud , Faika Jakanta
Published: January 2025

Background: Gestational trophoblastic disease encompasses a heterogeneous group of lesions arising from abnormal placental trophoblast proliferation. While molar pregnancy is the most common form, gestational trophoblastic neoplasia, though rare and often curable even with widespread dissemination, can follow any gestational event, including abortion, ectopic pregnancy, or term pregnancy. The aim of the study was to evaluate the various presentations and outcomes of gestational trophoblastic disease (GTD) in a tertiary hospital setting.
Methods: This retrospective study, conducted in the department of gynecological oncology at BSMMU from June 2023 to July 2024, included 173 patients with GTD. Diagnoses were confirmed using ultrasonography, serum beta-hCG, and histopathology. Data were retrospectively collected from medical records, documenting key demographic and clinical information. Ethical approval and informed consent were obtained. Data analysis was performed using SPSS version 22.
Results: Most participants were between 25-34 years (91.91%). The majority of GTD cases (54.91%) occurred in the 20-25 years age group, with bleeding per vagina being the most common clinical presentation (91.91%). Histopathology classified 72.83% of cases as complete moles. Treatment resulted in complete resolution for 85.55% of cases. Pre-evacuation beta hCG levels were above 100,000 IU/l in 72.83% of cases.
Conclusions: This study highlights the diverse presentations and favorable outcomes of gestational trophoblastic disease (GTD) in a tertiary hospital, emphasizing the importance of tailored management and monitoring strategies.
Pain relief by paracervical block during manual vacuum aspiration for early miscarriage
Authors: Zerin M. Ismat , Khatun M. Sharifa , Tamanna Zarin T. , Tamanna Musammat R. , Amin Rogina , Shilpi Umme S. , Ara Rifat
Published: January 2025

Background: Early miscarriage is a common clinical problem that requires safe and effective management. Manual vacuum aspiration (MVA) under paracervical block is a minimally invasive procedure that helps to minimize pain during the procedure. This study aims to determine the safety and effectiveness of paracervical block in reducing pain during MVA for early miscarriage.
Methods: A cross-sectional prospective observational study was conducted at the Department of Obstetrics and Gynaecology, Rajshahi Medical College Hospital, Bangladesh from January to June 2019. A total of 52 women with early miscarriages undergoing MVA were included. The procedure was done with a paracervical block given beforehand. Visual analog scale (VAS) was used to assess pain levels immediately after the procedure and 30 minutes later following the procedure.
Results: The average age of the patients (57%) was 20-30 years. The mean gestational age was 6-10 weeks, and 65.4 percent of patients had incomplete abortion. Immediately after MVA, 69.23% of patients had mild pain severity (VAS 0 to 3), though this rose to 80.77% at 30 minutes post procedure. The mean VAS scores was 2.92±1.38 immediately after procedure and 2.57±1.44 after 30 minutes of the procedure. The procedure was considered acceptable by most patients (86.54%) with few adverse effects.
Conclusions: During paracervical block for early miscarriage, MVA is a safe, effective and well tolerated means for pain relief and patient satisfaction.
Comparative study between vaginal isosorbide mononitrate and misoprostol for induction of cervical ripening prior to first trimester surgical abortion
Authors: Yadav Pawan , Singh Tanya , Singh Amrita , Shukla Savita
Published: January 2025

Background: To evaluate the efficacy of the tab. isosorbide mononitrate 80 mg and tab. misoprostol 400 µg given transvaginal for cervical ripening before surgical evacuation in early embryonic demise upto 12 weeks of gestation (missed abortion).
Methods: The present randomized controlled trial was conducted in Bebe Nanaki mother and child care centre, attached to govt. medical college, Amritsar, from August 2011 to September 2013 after approval of institutional research committee. All the 50 women were included after obtaining a written consent, and after proper history taking and examinations and were allocated randomly into two groups. In group A patients, tab. isosorbide mononitrate 80 mg was given and in group B patients, Tab. Misoprostol 400ug was given up to maximum of four doses until cervical dilatation of >8 mm has been achieved. Lack of cervical dilatation >8 mm after the 4th dose of medication was considered as a failure of treatment.
Results: In this study, the success rate was more with tab. misoprostol group (96%) as compared to tab. isosorbide mononitrate group (80%), whereas the failure rate with tab. misoprostol group was 4% and with tab. isosorbide mononitrate group was 20%. Cervical ripening with tab. misoprostol was rapid with less frequency of dosage and less induction to ripening interval. Specific side effects are there for both the groups.
Conclusions: In our study we observed that, tab. misoprostol appeared to be more effective than tab. isosorbide mononitrate.
Labour epidural analgesia and maternal and neonatal outcome
Authors: V. Rani , Natarajan Swathi
Published: January 2025

Background: This study was done to determine the maternal and neonatal outcomes in parturient who were administered with labour epidural analgesia. Primary objectives include the comparison of time to deliver after insertion of the epidural catheter at less than 4 cm and more than 4 cm of cervical dilatation, to determine the requirement of assistance for normal vaginal delivery, and also to determine adverse maternal outcomes.
Methods: The study was conducted at Arokya Women’s Centre, Salem, Tamil Nadu, India. The data was collected from medical records department, between July 2023 and June 2024. After obtaining written and informed consent, 749 parturient, who were willing for receiving labour epidural analgesia, were included in our study.
Results: In our study, majority of the parturient received labour epidural analgesia during their first stage of labour, i.e. less than 4 cm of cervical dilatation. The time to deliver in this age group is found to be more 465.4±393.3 minutes, as compared to those who were provided with labour epidural analgesia during their second stage of labour, 130.4±184, which was statistically significant (p value- 0.000).
Conclusions: We conclude that labour epidural analgesia, when administered between 1 and 4 cm of cervical dilatation, was helpful for parturient to have a pain-free, quicker delivery. We also observed that labour epidural did not cause an increased occurrence of post-partum haemorrhage among parturient and NICU admission among neonates.