bluuebunny/crossref_metadata_2025 huggingface dataset:
RNA Epigenetics in Chronic Lung Diseases
Authors: Wang Xiaorui , Guo Zhihou , Yan Furong
Published: December 2022

Chronic lung diseases are highly prevalent worldwide and cause significant mortality. Lung cancer is the end stage of many chronic lung diseases. RNA epigenetics can dynamically modulate gene expression and decide cell fate. Recently, studies have confirmed that RNA epigenetics plays a crucial role in the developing of chronic lung diseases. Further exploration of the underlying mechanisms of RNA epigenetics in chronic lung diseases, including lung cancer, may lead to a better understanding of the diseases and promote the development of new biomarkers and therapeutic strategies. This article reviews basic information on RNA modifications, including N6 methylation of adenosine (m6A), N1 methylation of adenosine (m1A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), 2′O-methylation (2′-O-Me or Nm), pseudouridine (5-ribosyl uracil or Ψ), and adenosine to inosine RNA editing (A-to-I editing). We then show how they relate to different types of lung disease. This paper hopes to summarize the mechanisms of RNA modification in chronic lung disease and finds a new way to develop early diagnosis and treatment of chronic lung disease.
Diagnostic and Prognostic Risk Assessment of Heat Shock Protein HSPA1B rs2763979 Gene Variant in Asthma
Authors: Faisal Salwa , Abdelaal Sherouk , Jeraiby Mohammed A. , Toaimah Fatihi Hassan Soliman , Kattan Shahad W. , Abdel-Gawad Abdelhady Ragab , Riad Eman , Toraih Eman A. , Fawzy Manal S. , Ibrahim Ahmed
Published: December 2022

Given the significant role the heat shock protein Hsp70 plays in modulating cellular homeostasis in several chronic inflammatory disorders, the genetic variation of the inducible HSP70 (HSPA1B) gene may impact protein expression and disease phenotype. The HSPA1B rs2763979 variant has been associated with multiple inflammatory scenarios, but no previous studies have explored its association with asthma. In this sense, this cross-sectional study enrolled 90 children with asthma and 218 age-/sex-matched healthy volunteers for rs2763979 variant genotyping by TaqMan allelic discrimination analysis. The results were investigated under several genetic models and associated with disease susceptibility and clinicolaboratory data. Overall analysis, including the 308 participants, revealed a higher C allele frequency among patients relative to controls (43.0% vs. 33%, p = 0.006). Furthermore, patients with the C variant initially had a higher risk of asthma under heterozygous (OR = 2.75, 95%CI = 1.46–5.18, p = 0.003), homozygous (OR = 3.35, 95%CI = 1.19–9.39, p = 0.008), dominant (OR = 2.83, 95%CI = 1.52–5.25, p < 0.001), and overdominant (OR = 2.12, 95%CI = 1.20–3.74, p = 0.008) models. However, after employing a 1:1 nearest propensity matching analysis, the studied variant showed only borderline significance with asthma under the dominant model in 71 matched cohorts. Interestingly, patients who carry the rs2763979 CC genotype showed favorable spirometric parameters in terms of better (mean ± SD) forced vital capacity (86.3 ± 7.4 vs. 77.7 ± 6.1 and 75.7 ± 7.2 for CT and TT, respectively, p = 0.021), forced expiratory volume in one second before bronchodilation (60.7 ± 12.9 vs. 54.9 ± 7.6 and 56.1 ± 7.5 for CT and TT, respectively, p = 0.021), and an improvement in peak expiratory flow rate after inhaled salbutamol bronchodilator (p = 0.044) relative to the counterpart genotypes. In conclusion, the HSPA1B rs2763979 variant might have prognostic utility as a genetic marker for asthma in our population. Further larger studies on different ethnicities are recommended to validate the results.
A Whole-Genome Sequencing Study Implicates GRAMD1B in Multiple Sclerosis Susceptibility
Authors: Esposito Federica , Osiceanu Ana Maria , Sorosina Melissa , Ottoboni Linda , Bollman Bryan , Santoro Silvia , Bettegazzi Barbara , Zauli Andrea , Clarelli Ferdinando , Mascia Elisabetta , Calabria Andrea , Zacchetti Daniele , Capra Ruggero , Ferrari Maurizio , Provero Paolo , Lazarevic Dejan , Cittaro Davide , Carrera Paola , Patsopoulos Nikolaos , Toniolo Daniela , Sadovnick A Dessa , Martino Gianvito , De Jager Philip L. , Comi Giancarlo , Stupka Elia , Vilariño-Güell Carles , Piccio Laura , Martinelli Boneschi Filippo
Published: December 2022

While the role of common genetic variants in multiple sclerosis (MS) has been elucidated in large genome-wide association studies, the contribution of rare variants to the disease remains unclear. Herein, a whole-genome sequencing study in four affected and four healthy relatives of a consanguineous Italian family identified a novel missense c.1801T > C (p.S601P) variant in the GRAMD1B gene that is shared within MS cases and resides under a linkage peak (LOD: 2.194). Sequencing GRAMD1B in 91 familial MS cases revealed two additional rare missense and two splice-site variants, two of which (rs755488531 and rs769527838) were not found in 1000 Italian healthy controls. Functional studies demonstrated that GRAMD1B, a gene with unknown function in the central nervous system (CNS), is expressed by several cell types, including astrocytes, microglia and neurons as well as by peripheral monocytes and macrophages. Notably, GRAMD1B was downregulated in vessel-associated astrocytes of active MS lesions in autopsied brains and by inflammatory stimuli in peripheral monocytes, suggesting a possible role in the modulation of inflammatory response and disease pathophysiology.
Revealing the Potential Markers of N(4)-Acetylcytidine through acRIP-seq in Triple-Negative Breast Cancer
Authors: Zhang Xingda , Zeng Jiaqi , Wang Jianyu , Yang Zihan , Gao Song , Liu Honghao , Li Guozheng , Zhang Xin , Gu Yue , Pang Da
Published: December 2022

Understanding the causes of tumorigenesis and progression in triple-receptor negative breast cancer (TNBC) can help the design of novel and personalized therapies and prognostic assessments. Abnormal RNA modification is a recently discovered process in TNBC development. TNBC samples from The Cancer Genome Atlas database were categorized according to the expression level of NAT10, which drives acetylation of cytidine in RNA to N(4)-acetylcytidine (ac4C) and affects mRNA stability. A total of 703 differentially expressed long non-coding RNAs (lncRNAs) were found between high- and low-expressed NAT10 groups in TNBC. Twenty of these lncRNAs were significantly associated with prognosis. Two breast cancer tissues and their paired normal tissues were sequenced at the whole genome level using acetylated RNA immunoprecipitation sequencing (acRIP-seq) technology to identify acetylation features in TNBC, and 180 genes were significantly differentially ac4c acetylated in patients. We also analyzed the genome-wide lncRNA expression profile and constructed a co-expression network, containing 116 ac4C genes and 1080 lncRNAs. Three of these lncRNAs were prognostic risk lncRNAs affected by NAT10 and contained in the network. The corresponding reciprocal pairs were “LINC01614-COL3A1”, “OIP5-AS1-USP8”, and “RP5-908M14.9-TRIR”. These results indicate that RNA ac4c acetylation involves lncRNAs and affects the tumor process and prognosis of TNBC. This will aid the prediction of drug targets and drug sensitivity.
A Multisite Assessment of Saudi Bachelor Nursing Students’ Perceptions of Clinical Competence and Learning Environments: A Multivariate Conceptual Model Testing
Authors: Abuadas Mohammad Hamdi
Published: December 2022

Background: It is thought that students’ perceptions of educational and clinical learning environments improve the effectiveness of curricula and professional standards. It is essential to examine the educational and clinical learning environments in which nursing students learn, as well as how nursing students evaluate particular factors of these environments. Objectives: The objectives of this study were to (1) identify nursing students’ perceptions on professional competence and learning environments in the classroom and clinical settings and (2) test a hypothetical model of variables that influence and predict students’ perceptions of learning environments and professional competencies. Methods: The study employed a descriptive cross-sectional methodological design. Five hundred and eighteen undergraduate nursing students were recruited from three Saudi Arabian universities using a convenient sampling technique. Using valid and reliable self-reported questionnaires, including the Dundee Ready Educational Environment Measure (DREEM), the modified Clinical Learning Environment Inventory (CLEI), and the Nurse Professional Competence Scale-Short (NPCS-SF), data were collected. Results: Perceptions of professional competence and learning environments were positive among nursing students. With satisfactory fit indices, the final model found that students’ perceptions of clinical competence were significantly predicted by their perceptions of the clinical environment (B = 0.43, p < 0.001), students’ perceptions of university environments (B = 0.29, p < 0.001), ward type (B = 0.12, p < 0.001), and students’ year of study (B = 0.11, p < 0.001). The students’ perceptions of clinical environments were significantly predicted by their perceptions of the university environment (B = 0.31, p < 0.001), gender (B = 0.13, p < 0.001), students’ year of study (B = 0.12, p < 0.001), and ward type (B = 0.11, p < 0.001). Moreover, the students’ perceptions of the university environment were significantly predicted by gender (B = 0.11, p < 0.001) and length of training (B = 0.12, p < 0.001). Conclusions: A range of factors might influence students’ perceptions of their professional competence and learning environments. Improving the learning environments and clinical experiences of students could enhance their clinical competence. This study’s findings provide evidence for how to enhance the learning environments in the classroom and clinical settings in order to improve students’ clinical competence, which will ultimately result in better patient outcomes. It is a top priority for nursing educators all around the world to improve classroom and clinical learning settings that foster students’ learning and professional competencies.
Patients’ Experience of Medication Brand Changes during Hormone Therapy for Breast Cancer—An Interpretative Phenomenological Analysis
Authors: Eraso Yolanda , Moon Zoe , Steinberga Ieva
Published: December 2022

Medication adherence to hormone therapy (HT) in breast cancer survivors is often suboptimal and is affected by a range of factors. Patients are usually prescribed different generic formulations of HT drugs and their impact on side effects and on adherence and persistence is poorly understood. This study aimed to explore women’s lived experience of HT medication brand changes (generic substitution) and its impact on side effects, quality of life and medication-taking behaviors, as well as on adherence and persistence. Nine female breast cancer survivors who had previous experience of HT medication brand changes participated in the study. Individual, online, semi-structured interviews were conducted and analyzed using interpretative phenomenological analysis. The findings identified three superordinate themes and nine subordinate themes that influenced the lived experience of medication brand changes for these patients: (i) experiencing brand changes, (ii) responsiveness of health care providers and (iii) future expectations. Women reported negative physical and emotional experiences of brand changes, which is often compounded by healthcare professionals’ lack of information and reassurances, disbelief in the worsening of side effects and inconsistent advice regarding generics. These have implications for women’s self-efficacy for medication-taking behaviors, ability to manage side effects and HT adherence and persistence.
Leaf Removal Impacted Jasmonic Acid Metabolism and AsA-GSH in the Roots of Malus baccata (L.) Borkh. under Suboptimal Low Root-Zone Temperatures
Authors: Dai Ping , Zhai Meiling , Li Lijie , Yang Huan , Ma Huaiyu , Lyu Deguo
Published: December 2022

In the early growing season in northern China, suboptimal low root-zone temperatures is a common abiotic stress that impairs root function and leaf development in fruit trees. In this study, we investigate the physiological role of leaves in jasmonate metabolism and the capacity of scavenging reactive oxygen species in Malus baccata (L.) Borkh. roots under suboptimal low root-zone temperatures. In the presence of intact leaves, suboptimal low root-zone temperatures significantly increased allene oxide synthase (AOS), jasmonate-resistant 1 (JAR), and jasmonic acid carboxyl methyltransferase (JMT) activities and transcription in jasmonate biosynthesis. Meanwhile, elevated endogenous jasmonic acid (JA), methyl jasmonate (MeJA), and jasmonate-isoleucine (JA-Ile) contents were also observed, as were significantly decreased glutathione reductase and dehydroascorbate reductase activities and AsA/DHA and GSH/GSSG ratios. Conversely, leaf removal substantially reduced AOS, JMT, and JAR activities and transcription at most time points and JA (6–24 h), MeJA (1–24 h), and JA-Ile (1–24 h) levels in roots, affecting key enzymes in the AsA–GSH cycle and the AsA/DHA and GSH/GSSG ratios in response to low-temperature treatment, as a result of a significant increase in malondialdehyde content. Thus, leaves are crucial for jasmonate metabolism in roots under suboptimal low root-zone temperatures, with leaf removal exacerbating root oxidative stress by altering JA signaling and AsA–GSH cycle activity.
Correlations between the Phylogenetic Relationship of 14 Tulasnella Strains and Their Promotion Effect on Dendrobium crepidatum Protocorm
Authors: Zhao Jiayi , Li Zhenjian , Wang Siyu , Yang Fu , Li Lubin , Liu Lei
Published: December 2022

The compatibility of mycorrhizal fungi with the early growth stage of orchids is essential for their growth. In this study, the compatibility and promotion effects of 14 Tulasnella strains from different hosts were studied by co-culturing them with the protocorms of Dendrobium crepidatum, which has high ornamental and economic value in China. The ITS–LSU–SSU–TEF combined sequence analysis divided the 14 strains into three clades belonging to Tulasnella calospora (clades A and B) and Tulasnella asymmetrica (clade C). All the strains were compatible with D. crepidatum protocorms within 90 d of the co-culture. Strain T12 in Clade A had a significantly higher (p < 0.05) effect on the biomass and morphology of D. crepidatum, and strain T13 in Clade C had a significantly lower (p < 0.05) effect than the other strains. Through morphological principal component analysis, we constructed a hierarchical cluster analysis tree, which was consistent with the phylogenetic tree of these 14 strains at the clade level. Orthogonal partial least squares-discriminant analysis showed that these strains have an important effect on the plant height, root number, and length of D. crepidatum. The findings of this study will contribute to the identification of Tulasnella strains, conservation of D. crepidatum resources, and commercial utilization of mycorrhizal technology.
Influence of Biochar Mixed into Peat Substrate on Lettuce Growth and Nutrient Supply
Authors: García-Rodríguez Álvaro F. , Moreno-Racero Francisco J. , García de Castro Barragán José M. , Colmenero-Flores José M. , Greggio Nicolas , Knicker Heike , Rosales Miguel A.
Published: December 2022

The use of peat in traditional cultivation systems and in commercial nurseries is an environmental problem. In this work, we evaluated the partial replacement of peat with different amounts of biochar sourced from vineyard pruning as plant growing substrates. We studied its effect on the growth of lettuce plants under greenhouse and semi-hydroponic conditions. Substrate mixtures contained 30% (v/v) of vermiculite and 70% (v/v) of different biochar:peat treatments as follows: 0:70 (B0), 15:55 (B15), 30:40 (B30), 50:20 (B50), and 70:0 (B70). Higher biochar treatments increased the pH and electrical conductivity of the substrate, negatively affecting plant growth and germination (especially in B70). The partial substitution of peat by 30% biochar (B30) delayed seed germination but improved plant growth and nitrogen use efficiency (NUE), with shoots containing higher levels of organic nitrogen and nitrate. Moreover, it increased the water holding capacity (WHC) and led to an efficient use of nutrients. Our study demonstrates that biochar can successfully replace and reduce peat and N fertilizer consumption. This has the potential to promote more sustainable farming with positive impacts on both plant growth and the environment.
Development of BC3F2 Tomato Genotypes with Arthropod Resistance Introgressed from Solanum habrochaites var. hirsutum (PI127826)
Authors: Panizzon Diniz Flávia Cristina , Vilela de Resende Juliano Tadeu , Lima-Filho Renato Barros de , Pilati Laura , Gomes Gabriella Correia , Roberto Sergio Ruffo , Da-Silva Paulo Roberto
Published: December 2022

Arthropod pests are among the biggest problems faced in tomato production worldwide. To overcome the losses caused by these pests, one of the most sustainable and economical strategies is the use of resistance introgressed from wild species. We aimed to develop BC3F2 tomato genotypes with high levels of zingiberene (ZGB) and resistance to whitefly (Bemisia tabaci biotype B), South American tomato pinworm (Tuta absoluta), and the two-spotted spider mite (Tatranychus urticae), from the wild accession of Solanum habrochaites var. hirsutum (accession PI127826). The quantification of ZGB in 520 BC3F2 genotypes and in the parentals yielded the selection of five genotypes with high ZGB content and three with low ZGB content, which were then infested with B. tabaci, T. absolute, and T. urticae. In these eight genotypes and in the parents, the types and amounts of trichomes on the leaves were determined. Additionally, molecular markers were used to identify the genotypes with a higher recurrent genome recovery. The results confirmed the transfer of resistance from S. habrochaites to the BC3F2 genotypes and showed that this resistance seems to be directly related to high concentrations of ZGB and the presence of type IV trichomes.
Chemotypes of Species of the Genus Thymus L. in Carpathians Region of Ukraine—Their Essential Oil Qualitative and Quantitative Characteristics and Antimicrobial Activity
Authors: Kryvtsova Maryna , Hrytsyna Myroslava , Salamon Ivan , Skybitska Maria , Novykevuch Olha
Published: December 2022

The study of the R&D in this paper is to determine the range of essential oils (EOs) in the raw materials of species of the genus Thymus of the natural flora in the Carpathian region and their antimicrobial activity. It was found that the component range of EO in species of the genus Thymus depends on the microclimatic conditions of the population. The range of essential oils in the raw material of Th. Serpyllum and Th. Pulegoides is 7–9 mL and Th. Marschallianus is 3.5 mL. The research found that the plants Th. Serpyllum and Th. Pulegoides that grow in sunny habitats have an aromatic mono- and bicyclic monoterpenoid chemotype (K/α-T-neol/ G/p-C/B), with total dominance of carvacrol and p-cymene. The populations of Th. Serpyllum, which grow on the edges of sparse pine forests, and populations of Th. Pullegioide, with denser plant cover and which grow in meadows, have an acyclic and bicyclic monoterpene chemotype (G/α-T-neol/B/K). Plants that grow in the communities of meadow-steppe vegetation have the following chemotypes: Th. Serpyllum—L/K/G with 63% of linalool, Th. Pullegioides—G/α-T-neol/L/B, and Th. Marschallianus—α-T-neol/K/L/α-T-nen/G/B. Of these, the dominant chemotypes are α-terpineol and carvacrol (28:6.5%). A wide spectrum of antimicrobial activity was registered in samples of Th. Pullegoides and Th. Serpyllum that have an aromatic-monoterpenoid chemotype. Essential oils of Th. Pullegoides were dominated by carvacrol, and p-cymene had the highest fungicidal action (41.00 ± 1.0%). Plant populations of Th. Pullegoides and Th. Serpyllum with the aromatic-monoterpenoid chemotype are suggested by R&D to be of use in the pharmaceutical industry. They have high contents of natural components, which are effective in a wide spectrum of antimicrobial activity. The EO of Th. Marschallianus had the lowest influence on the inhibition of bacterial and fungal reproduction.
Advances in Flow Modeling for Water Resources and Hydrological Engineering
Authors: Costanzo Carmelina , Padulano Roberta , Caloiero Tommaso
Published: December 2022

Surface and ground waters can be considered the main sources of water supply for agricultural, municipal, and industrial consumers. Over the centuries, the combination of both naturally occurring conditions and humanity’s actions has placed increasing pressure on these water resources. As an example, climate change and natural variability in the distribution and occurrence of water are among the natural driving forces that complicate the sustainable development of water resources. Recent advances in computer techniques have allowed scientists to develop complex models at different scales to support water-resource planning and management. The Special Issue “Advances in Flow Modeling for Water Resources and Hydrological Engineering” presents a collection of scientific contributions providing a sample of the state-of-the-art research in this field.
The Utility of High Intensity Interval Training to Improve Cognitive Aging in Heart Disease Patients
Authors: Taylor Jenna L. , Barnes Jill N. , Johnson Bruce D.
Published: December 2022

Adults with cardiovascular disease and heart failure are at higher risk of cognitive decline. Cerebral hypoperfusion appears to be a significant contributor, which can result from vascular dysfunction and impairment of cerebral blood flow regulation. In contrast, higher cardiorespiratory fitness shows protection against brain atrophy, reductions in cerebral blood flow, and cognitive decline. Given that high intensity interval training (HIIT) has been shown to be a potent stimulus for improving cardiorespiratory fitness and peripheral vascular function, its utility for improving cognitive aging is an important area of research. This article will review the physiology related to cerebral blood flow regulation and cognitive decline in adults with cardiovascular disease and heart failure, and how HIIT may provide a more optimal stimulus for improving cognitive aging in this population.
Swedish High School Students’ Drug and Alcohol Use Habits throughout 2020
Authors: Sfendla Anis , Bador Kourosh , Paganelli Michela , Kerekes Nóra
Published: December 2022

This study describes gender-specific patterns in alcohol and drug use among Swedish high school students throughout 2020 and questions the current cutoffs for identifying addiction in this population. From September 2020 to February 2021, 1590 Swedish upper secondary high school students (mean age 17.15 years, age range 15–19 years, 39.6% male, and 60.4% female) completed the anonymous, electronic survey of the Mental and Somatic Health without borders study. The respondents reported their substance use habits during the previous 12 months using the Drug Use Disorders Identification Test (DUDIT) and Alcohol Use Disorders Identification Test (AUDIT). They also answered questions about changes in their alcohol and illegal drug use habits after the COVID-19 outbreak. No gender differences were detected in the prevalence and degree of alcohol use. Compared to female adolescents, significantly more male adolescents used drugs (and to a significantly higher degree, although with a small effect size). Substance use problems peaked in females at age 17 and in males at age 18. The COVID-19 outbreak affected alcohol consumption and illegal drug use in male and female adolescents similarly. For both genders, of those who used illegal drugs, over 40% reported increased use after the outbreak. Our results reinforce previous suggestions of the narrowing of gender differences in Swedish adolescents’ risk behaviors and challenge the previously validated gender-specific cutoffs for the AUDIT and DUDIT. An improved understanding of the impacts of gender diversity and evolving gender roles and norms on behaviors and mental health is warranted.
Spatial Distribution Profiles and Human-Health Risks of Heavy Metals in Surrounding Area Surface Soils of a Petrochemical Complex
Authors: Yi Miao , Zhang Shiyi , Li Min , Xiang Jun , Tang Bin , Yan Xiao , Zheng Jing , Li Guiying , An Taicheng
Published: December 2022

Despite the growing concern raised by organic pollutants from the petrochemical industry to the surrounding soils, the heavy metal (HM) pollution in these soils remains understudied. This study investigated the levels, potential sources, and human-health risks of 12 HMs in soils inside and in surrounding areas of a petrochemical complex. Generally, the levels of 12 HMs in all soil samples were lower than the national standard of China, except for the Cd in one surrounding soil sample. Approximately 40.9% and 98.1% of soils around and inside the petrochemical complex, respectively, were at slightly contaminated levels. The HM pollution in 94.4% of soils inside and 32% of soils in surrounding areas were mainly affected by petrochemical production. Human-health risk showed that although As posed an acceptable cancer risk for adults both in and around the complex, high cancer risk for surrounding children from As was observed. Moreover, around the complex, Cr, Cd, and Pb posed acceptable cancer risks for children, while Cd posed an acceptable cancer risk for adults. The spatial distribution of the health risks decreased with increasing distance from the complex. Overall, our results demonstrate that it is essential to minimize human exposure to HMs originating from the petrochemical industry, especially As, Cr, Cd, and Pb.
Placement Architectures in Practice: An Exploration of Student Learning during Non-Traditional Work-Integrated Learning in Rural Communities
Authors: Green Elyce , Hyde Sarah , Barry Rebecca , Smith Brent , Seaman Claire Ellen , Lawrence Jayne
Published: December 2022

Background: Work-integrated learning (WIL) in rural communities provides students with important learning opportunities while also providing a service to those communities. To optimise the potential benefits of work-integrated learning for health students and rural communities it is important to explore the practices and outcomes of these experiences. Methods: This study used a qualitative research design underpinned by the theoretical framework of Theory of Practice Architectures to examine the way students learn during these placements. Purposive sampling was used to identify students for participation in the study. Seven students from the disciplines of paramedicine, physiotherapy, and speech pathology participated in semi-structured interviews. Data were analysed using inductive thematic analysis. Results: The learning described by the students was examined, followed by a critical interrogation of the data to assess how these learnings and associated practices were made possible given the site-specific practice architectures. The findings of the research are represented by three themes: learning affordances related to placement design, learning through relationships between people and professions, and learning through rural embeddedness. Conclusion: Being embedded in rural communities gave the students access to several arrangements that fostered learning, particularly through the sayings, relatings and doings that the students engaged with. This research demonstrates the transformative potential of rural WIL opportunities for learning and future rural practice.
The Epidemiology of Young People’s Work and Experiences of Violence in Nine Countries: Evidence from the Violence against Children Surveys
Authors: Bhatia Amiya , Parvez Maryam , Pearlman Jodie , Kasalirwe Fred , Kiss Ligia , Kyamulabi Agnes , Walakira Eddy J. , Devries Karen , Tanton Clare
Published: December 2022

Globally, 497 million young people (15–24 years) are in the labour force. The current research on work and violence indicates reciprocal links across the life course. This study draws on data from 35,723 young people aged 13–24 years in the Violence Against Children Surveys (VACS) in nine countries to describe the epidemiology of work in order to explore associations between (1) current work and violence and (2) childhood violence and work in a hazardous site in young adulthood. The prevalence of past-year work among 13–24-year-olds was highest in Malawi: 82.4% among young men and 79.7% among young women. In most countries, young women were more likely to be working in family or domestic dwellings (range: 23.5–60.6%) compared to men (range: 8.0–39.0%), while men were more likely to be working on a farm. Work in a hazardous site was higher among young men compared to women in every country. Among children aged 13–17 years, we found significant positive associations between past-year work and violence among girls in three countries (aORs between 2.14 and 3.07) and boys in five countries (aORs 1.52 to 3.06). Among young people aged 18–24 years, we found significant positive associations among young women in five countries (aORs 1.46 to 2.61) and among young men in one country (aOR 2.62). Associations between childhood violence and past-year work in a hazardous site among 18–24-year-olds were significant in one country among girls and in three countries among boys. Continued efforts are needed to prevent hazardous work, improve work environments, and integrate violence prevention efforts into workplaces.
A Low-Cost Electrochemical Method for the Determination of Sulfadiazine in Aquaculture Wastewater
Authors: Liu Yang , Chen Jianlei , Hu Haiyan , Qu Keming , Cui Zhengguo
Published: December 2022

As the concept of green development spreads worldwide, environmental protection awareness for production and life has been continuously strengthened. Antibiotic residues in aquaculture wastewaters aggravate environmental pollution and threaten human health. Therefore, the detection of residual antibiotics in wastewater is crucial. In this paper, a new, simple, and low-cost method based on the glassy carbon electrode electrochemical sensor for the detection of sulfadiazine in aquaculture wastewater was developed without using complex materials to modify the electrode surface, to detect sulfadiazine which electrochemically oxidizes directly. The electrochemical performance of the sensor was studied and optimized with differential pulse voltammetry and cyclic voltammetry in the three-electrode system. The optimal electrolyte was acetic acid-sodium acetate buffer, and the optimal pH was 4.0. Finally, based on the optimized conditions, the newly established method showed satisfactory results for detecting sulfadiazine in aquaculture wastewater. The concentration of sulfadiazine and the peak current intensity showed a linear relationship in the range of 20 to 300 μmol/L, and the limit of detection was 6.14 μmol/L, the recovery rate of standard addition was 87–95%, with satisfactory reproducibility and low interference.
Positive Effects of Organic Substitution in Reduced-Fertilizer Regimes on Bacterial Diversity and N-Cycling Functionality in Greenhouse Ecosystem
Authors: Sun Na , Wang Liying , Sun Yanxin , Li Hong , Liao Shangqiang , Ding Jianli , Wang Guoliang , Suo Linna , Li Yanmei , Zou Guoyuan , Huang Shaowen
Published: December 2022

Conventional fertilization in the greenhouses of North China used excessive amounts of chemical and organic fertilizer, resulting in soil degradation and severe agricultural non-point source pollution. A nine-year study was conducted on a loamy clay soil in Shijiazhuang, Hebei province, to investigate the effects of reduced-fertilizer input regimes on soil property, bacterial diversity, nitrogen (N) cycling and their interactions. There were four treatments, including high organic + chemical fertilizer application rate and three reduced-fertilizer treatments with swine manure, maize straw or no substitution of 50% chemical N. Treatments with reduced-fertilizer input prevented soil salinization and acidification as in local conventional fertilization after being treated for nine years. In comparison to chemical fertilizer only, swine manure or maize straw substitution maintained higher nutrient availability and soil organic C contents. Fertilizer input reduction significantly increased bacterial richness and shifted bacterial community after nine years, with decisive factors of EC, Olsen P and C/N ratio of applied fertilizer. Soil chemical characteristics (EC, pH and nutrients), aggregation and C/N ratio of applied fertilizer selected certain bacterial groups, as well as N-cycling functions. Reduced-fertilizer input decreased the potential nitrification and denitrification functioning of bacterial community, but only in organic substitution treatments. The results of this study suggested that fertilizer input reduction combined with organic C input has potential in reducing non-point source pollution and increasing N-use efficiency in greenhouse vegetable production in North China.
Does the Creation of Food Safety Demonstration Cities Promote Agricultural Development? Evidence from China
Authors: Lv Jie , Huang Lu , Li Xiaoting
Published: December 2022

The creation of food safety demonstration cities (CFSDC) is among the key measures the Chinese government implemented to address the intensifying food safety problem. While effectively managing food safety issues, whether this measure will have an impact on agricultural development in China remains unknown. In this paper, based on panel data from 277 cities in China from 2011 to 2019, the impact of the construction of food safety demonstration cities on agricultural development is empirically examined using the difference-in-differences (DID) model. The results show that the CFSDC significantly improves the level of agricultural development, which still holds after various robustness tests. Analysis of the underlying mechanism indicates that the CFSDC promotes urban agricultural development by accelerating both technological innovation and industrial restructuring. The results of heterogeneity analysis show that the policy effects of the CFSDC exhibit significant heterogeneous characteristics depending on city size, city location, and city administrative level. The findings contribute to the understanding of the relationship between policy pilot projects and agricultural development and provide empirical support for promoting the governance of food safety issues and agricultural development.
ADIDAS: An Examined Approach for Enhancing Cognitive Load and Attitudes towards Synchronous Digital Learning Amid and Post COVID-19 Pandemic
Authors: Salem Mostafa Aboulnour , Sobaih Abu Elnasr E.
Published: December 2022

SARS-CoV-2 (COVID-19) has disrupted university education and turned it into distance learning for at least one semester in many countries, including the Kingdom of Saudi Arabia (KSA). However, there was an issue with university students’ cognitive load at this critical time, because education totally stopped for about a month and then resumed remotely. This research draws on the cognitive load theory, particularly the extraneous load, to develop an instructional design model called ADIDAS. The model includes six stages, namely: analyse (A), design (D), improve (I), do (D), Assess (A), and Share (S). Thirty-four experts in instructional technology models have reviewed the ADIDAS model in Arab university contexts, producing a consensus about its suitability for use in distance learning amid the COVID-19 pandemic. Following the consensus of the experts, the model was applied to a sample of 527 students at King Faisal University, KSA. The results confirmed significant statistical differences with a very large effect size in relation to the attitude towards synchronous digital learning (SDL) and cognitive load pre and post ADIDAS. Students had a positive attitude towards SDL and a low cognitive load during the educational process pre adoption of the ADIDAS model, compared to post ADIDAS. The current research results have numerous implications for post the COVID-19 pandemic, especially in Arab countries and similar contexts.
Evaluation of a Trauma-Informed Parenting Program for Resource Parents
Authors: Stenason Lauren , Romano Elisa
Published: December 2022

Child maltreatment impacts many young people involved in the child welfare system, and it is important that the resource parents supporting these youth have knowledge and skills in trauma-informed care. The current study is a preliminary evaluation of the Resource Parent Curriculum (RPC), an in-service, 8-module, group-based parenting program developed by the National Child Traumatic Stress Network. Youth and caregiver outcomes were examined by way of a quasi-experimental design that included 22 resource parents in the experimental group and 21 in the waitlist control group and involved baseline, post-program, and 2-month follow-up assessments. For learning outcomes, RPC resulted in improvements in resource parents’ knowledge and beliefs about trauma-informed parenting. While not statistically significant, potential effects included improvements in resource parents’ tolerance of challenging youth behaviors and parenting self-efficacy. For behavioral outcomes, several non-significant potential effects were noted, including improvements in resource parents’ attachment relationships with their youth and increased social supports. This study was the first to evaluate RPC using a quasi-experimental design within a Canadian context and through a virtual delivery. Findings highlighted several benefits of the program and resource parents’ ongoing training needs.
A Call for Action on Chronic Respiratory Diseases within Physical Activity Policies, Guidelines and Action Plans: Let’s Move!
Authors: Orme Mark W. , Jayamaha Akila R. , Santin Lais , Singh Sally J. , Pitta Fabio
Published: December 2022

Global policy documents for the promotion of physical activity (PA) play an important role in the measurement, evaluation, and monitoring of population PA levels. The World Health Organisation (WHO) guidelines include, for the first time, recommendations for specific populations, including individuals living with a range of non-communicable diseases. Of note, is the absence of any chronic respiratory diseases (CRDs) within the recommendations. Globally, CRDs are highly prevalent, are attributable to significant individual and societal burdens, and are characterised by low PA. As a community, there is a need to come together to understand how to increase CRD representation within global PA policy documents, including where the evidence gaps are and how we can align with PA research in other contexts. In this commentary, the potential for synergy between evidence into the relationships between PA in CRDs globally and the relevance to current policies, guidelines and action plans on population levels of PA are discussed. Furthermore, actions and considerations for future research, including the need to harmonize and promote PA assessment (particularly in low- and middle-income countries) and encompass the synergistic influences of PA, sedentary behaviour and sleep on health outcomes in CRD populations are presented.
Challenges in the Diagnosis of Tertiary Syphilis: Case Report with Literature Review
Authors: Jankowska Lucyna , Adamski Zygmunt , Polańska Adriana , Bowszyc-Dmochowska Monika , Plagens-Rotman Katarzyna , Merks Piotr , Czarnecka-Operacz Magdalena , Żaba Ryszard
Published: December 2022

Tertiary syphilis is a large diagnostic challenge. It is rarely the case that it affects the skin, bone tissue and the eyes at the same time. The presented case shows that extensive symptomatology of syphilis poses a challenge in making a proper diagnosis in patients whose history does not suspect STDs. The study aims to present the case of a young woman hospitalized with a suspected autoimmune disease, diagnosed with symptomatic late syphilis with involvement of the skin, bones and eyes.
Ableism, Human Rights, and the COVID-19 Pandemic: Healthcare-Related Barriers Experienced by Deaf People in Aotearoa New Zealand
Authors: Roguski Michael , Officer Tara N. , Nazari Orakani Solmaz , Good Gretchen , Händler-Schuster Daniela , McBride-Henry Karen
Published: December 2022

The COVID-19 pandemic significantly affected global healthcare access and exacerbated pre-pandemic structural barriers. Literature on disabled people’s experiences accessing healthcare is limited, with even less framing healthcare access as a human rights issue. This study documents and critically analyses Deaf people’s healthcare access experiences in Aotearoa New Zealand during the COVID-19 pandemic. Eleven self-identified Deaf individuals participated in semi-structured videoconferencing interviews. Discourse analysis was applied to participant narratives with discourses juxtaposed against a human rights analysis. Barriers influencing healthcare access included: (1) the inability of healthcare providers to communicate appropriately, including a rigid adherence to face mask use; (2) cultural insensitivity and limited awareness of Deaf people’s unique needs; and (3) the impact of ableist assumptions and healthcare delaying care. Barriers to healthcare access represent consecutive breaches of rights guaranteed under the United Nations Convention on the Rights of Persons with Disabilities (CRPD). Such breaches delay appropriate healthcare access and risk creating future compounding effects. Action is required to address identified breaches: (1) The CRPD should also underpin all health policy and practice development, inclusive of pandemic and disaster management responsiveness. (2) Health professionals and support staff should be trained, and demonstrate competency, in Deaf cultural awareness and sensitivity.
Self-Rated Health and Life Satisfaction among Elderly Migrants in China: A Moderated Mediation Model of Resilience and Upward Intergenerational Support
Authors: Zhang Li , Hou Yanjie , Wang Hao , Yao Jun
Published: December 2022

Objective: This study aimed to test whether resilience mediates the association between self-rated health and life satisfaction and the moderated effect of upward intergenerational support among elderly migrants in China. Method: We used self-reported data collected from 654 elderly migrants in Nanjing. The regression analysis using bootstrapping methods was conducted to explore the mediating and moderating effects. Results: Resilience mediated the relationship between self-rated health and life satisfaction among elderly migrants in China. The moderated mediation analysis indicated that the upward intergenerational support moderated the path between self-rated health and resilience. Specifically, compared with those with a low level of emotional support, the self-rated health of elderly migrants with a high level of emotional support has a stronger effect on resilience. Moreover, the self-rated health of elderly migrants with a low level of financial support has a stronger effect on resilience than those with a higher level of financial support. Conclusion: Resilience could partially mediate the effect of self-rated health on life satisfaction among elderly migrants in China, and upward intergenerational support moderated the indirect relationship between self-rated health and life satisfaction via resilience.
Systematic Review of Smoking Cessation Interventions for Smokers Diagnosed with Cancer
Authors: Frazer Kate , Bhardwaj Nancy , Fox Patricia , Stokes Diarmuid , Niranjan Vikram , Quinn Seamus , Kelleher Cecily , Fitzpatrick Patricia
Published: December 2022

The detrimental impact of smoking on health and wellbeing are irrefutable. Additionally, smoking is associated with the development of cancer, a reduction treatment outcomes and poorer health outcomes. Nevertheless, a significant number of people continue to smoke following a cancer diagnosis. Little is understood of the smoking cessation services provided to smokers with cancer or their engagement with them. This systematic review aimed to identify existing smoking cessation interventions for this cohort diagnosed with breast, head and neck, lung and cervical cancers (linked to risk). Systematic searches of Pubmed, Embase, Psych Info and CINAHL from 1 January 2015 to 15 December 2020 were conducted. Included studies examined the characteristics of smoking cessation interventions and impact on referrals and quit attempts. The impact on healthcare professionals was included if reported. Included studies were restricted to adults with a cancer diagnosis and published in English. No restriction was placed on study designs, and narrative data synthesis was conducted due to heterogeneity. A review protocol was registered on PROSPERO CRD 42020214204, and reporting adheres to PRISMA reporting guidelines. Data were screened, extracted in duplicate and an assessment of the quality of evidence undertaken using Mixed Methods Assessment Tool. 23 studies met the inclusion criteria, representing USA, Canada, England, Lebanon, Australia and including randomized controlled trials (9), observational studies (10), quality improvement (3), and one qualitative study. Hospital and cancer clinics [including a dental clinic] were the settings for all studies. 43% (10/23) of studies reported interventions for smokers diagnosed with head and neck cancer, 13% (3/23) for smokers diagnosed with lung cancer, one study provides evidence for breast cancer, and the remaining nine studies (39%) report on multiple cancers including the ones specified in this review. Methodological quality was variable. There were limited data to identify one optimal intervention for this cohort. Key elements included the timing and frequency of quit conversations, use of electronic records, pharmacotherapy including extended use of varenicline, increased counselling sessions and a service embedded in oncology departments. More studies are required to ensure tailored smoking cessation pathways are co-developed for smokers with a diagnosis of cancer to support this population.
Pro-Environmental Behavior: Examining the Role of Ecological Value Cognition, Environmental Attitude, and Place Attachment among Rural Farmers in China
Authors: Meng Lin , Si Wentao
Published: December 2022

Studies on the factors that influence farmers’ pro-environmental behavior could promote environmental management in rural areas. Jinan of China was selected as the case study area in this study. A structural equation model and multiple hierarchical regression analysis were applied to analyze the influence mechanism of ecological value cognition on pro-environmental behavior. Environmental attitudes were set as the mediating variable and place attachment was selected as the moderating variable. The results showed that (1) ecological value cognition exhibited a positive influence on pro-environmental behavior in both direct and indirect ways. The indirect influence was mediated by environmental attitude. (2) Place identity and place dependence showed a positive direct influence on pro-environmental behavior. (3) It is suggested that in order to improve pro-environmental behavior, enhancing ecological value cognition, cultivating farmers’ positive environmental attitude, increasing farmers’ place attachment, and releasing reward and punishment measures are good strategies. The findings in this study are important to the improvement of the rural ecological environment and the quality of life of farmers. Meanwhile, the findings shed light on the construction process of ecological civilization and the improvement of public welfare.