bluuebunny/crossref_metadata_2025 huggingface dataset:
Contesting Discourses and Transmodalization in J.M.Coetzee’s Fiction
Authors: Ghaznavi Sadia
Published: December 2021

South African metafictive literature by white writers, specifically J. M. Coetzee (Nobel laureate, 2003), is essentially pivoted on the black-white dialectics of discourse. The narrative is informed with a variety of sociopolitical inflections that pronounce in various ways the contemporary ideology in South African literature. Critics have greatly delineated the racio-political quagmire of the colonial subject in metafictive literature appearing in the last few decades of twentieth century. However, a deeper analysis of the representation of the colonial subject that interrogates the discourses in narrative is still untapped. J.M.Coetzee’s South African-based novels, mainly Waiting for the Barbarians (1980), Life and Times of Michael K (1983) and Age of Iron (1990), manifest a metafictional consciousness that investigates the constructs of reality of the colonial subject. It is significant to explore the logocentric premise in the representation of colonial subject and how this contributes to the meaning of the fictional word. This study is a narratological research of Coetzee’s technique of transmodalization (narrative mode shifts) between two types of discourses, the pedagogical and performative, and employs Homi K Bhabha’s (1994) theoretical framework of representative discourse. In examining the narrative mode shifts between frame breaks, metanarrative, narrative of words, narrative of dreams, and narrative of topography, this research argues that a non-position is generated between the contesting discourses. This research becomes a model for the study of colonial dynamics in metafictive white writing. It aims to unravel the elements integral in voicing the conditionality of the colonized subject and the contention of representation. This study also explores the metonymical relationships in narrative that reflect intrinsic aspects of the signification of representation.
Lessons Learned: COVID 19 and Individuals Experiencing Homelessness in the Global Context
Authors: Karabanow Jeff , Seven Bozcam Emel , Hughes Jean , Wu Haorui
Published: December 2021

The coronavirus disease (COVID-19) pandemic has affected all our lives but did not affect all parts of societies equally. This study uses a systematic literature review approach to examine the experiences of homeless populations during COVID-19. Our literature review identified lessons learned and promising practices from the field at a global level, and summarizes academic studies in order to promote future efforts to prepare homeless populations for potential extreme events in the future. Forty-one of 209 articles were selected to prepare this literature review. Following the academic database search, grey literature from various organizations were also identified to enrich the literature results and analysis. Findings from these articles were grouped under three main themes to better illustrate the results: (1) impact of COVID-19 on people experiencing homelessness (PEH), (2) support mechanisms, and (3) promising practices. A comparative approach also was used to examine how PEH responded during two previous pandemics (severe acute respiratory syndrome [SARS] in 2003 and Swine Flu 2009) compared to the COVID-19 pandemic. Findings showed that there was continuous improvement in the disaster preparedness for PEH during COVID-19 when compared to past pandemics. In addition, promising practices have emerged. However, ongoing issues, such as lack of personal protective equipment (PPE), staff shortages, and communication problems, still persist in the field. More research regarding PEH during pandemics is needed, and their voices should be included.
Relevansi Transformational Leadership Di Lembaga Pendidikan Kristen
Authors: Windarwati Maria Titik , Sirait Junio Richson , Istinatun Hestyn Natal , Parulian Tamba , Emeliana Emeliana
Published: December 2021

Transformational leadership is a leadership model that is still relevant to use today. All Christian educational institutions require this pattern to develop quality in every implementation of the civitas academical. This paper aims to examine the relevance of transformation leadership patterns in Christian educational institutions through literature studies. The method in this research uses literature studies with descriptive analysis techniques. Through this study concluded that transformational leadership patterns are very relevant to be applied. Through this study, concluded that transformational leadership is very relevant to implemented in educational institutions. Transformational leadership has a role important in the achievement of the quality of education in Christian educational institutions.
Pengajaran Makna Kata Telanjang Berdasarkan Kejadian 3:1-7
Authors: Istinatun Hestyn Natal , Kristiawan Ragil , Daliman Muner , Sirait Junio Richson
Published: December 2021

Genesis 3:1-7 is the most important of the four chapters in the chapter. The problem that occurred was when the woman in the garden came face to face with a snake who said to her, “you will never die” (Gen 3:4). These words resulted in a dialogue that made the woman not only see and think that the fruit gave understanding, but she also took, ate and gave it to her husband and her husband ate it (Gen 3:6). This action has caused their eyes to be opened so that they know that they are naked (Gen. 3:7a), and they make their loincloths, because naked is a picture of their sinful condition. Meanwhile the LORD God had announced His Law “…in the day that you eat of it, you shall surely die” Genesis 2:17.
Ujian Kesetiaan Persembahan Dimasa Pandemi Covid-19 Berdasarkan Maleakhi 3:10
Authors: Situmeang Saul , Ferinia Rolyana , Hutagalung Stimson
Published: December 2021

The Covid-19 pandemic has disrupted the financial structure of church members. The dilemma when it comes to paying offerings and tithing or making a living. Based on this dilemma gap, the purpose of this study is to describe the offerings and tithes of the Natar district congregation and to analyze the faithfulness of church members in paying tithes and offerings. This research method was qualitative with a descriptive approach. The data collection technique used were financial data from the church treasurer about offerings and tithes giver. The first stage was to create a data graph to see the giving unit and the second stage was analyze the economic situation of the congregation and the level of faithfulness of the congregation. The results of the ongoing COVID-19 pandemic research increase the faith of church members through the provision of integrated offerings that increase during the pandemic and the giving of tithes given every month. Evidence of increased faith is that they are more enthusiastic and active in preaching the gospel.
ABOUT THE CREATIVE ROLE OF N. NAZARBAYEV IN CREATING AN EFFECTIVE GOVERNANCE SYSTEM IN INDEPENDENT KAZAKHSTAN
Authors:   Institute of Diplomacy, Academy of Public Administration under the President of the Republic of Kazakhstan, Suleimenov Tuleutai
Published: December 2021

Kazakhstan at the present stage has the status of a large regional state in the Eurasian space, plays an active role in the system of international relations, occupying a worthy place on the political map of the world. The strategy of independence of N. A. Nazarbayev formed the basis for the vision of modernizing modern Kazakhstani society and strengthening the independence of our country in the new world. The values ​​of our independence: multinationality of a single people, common national interests, education and science, demarcation of state borders, peaceful foreign policy.
MANAGEMENT RISKS OF DIGITAL DEVELOPMENT STRATEGY IMPLEMENTATION
Authors:   General Director of Smart Technologies Solutions LLP, PhD candidate Almaty Management University (AlmaU), Batyrbekova Maiya
Published: December 2021

Risk management is becoming a key area of expertise of IT projects, particularly for projects in which directly or indirectly take part a significant number of natural and legal entities, representatives of state agencies and authorities.The main risks of multifunctional IT projects and management practices are shown in the present article.
Repertoires of MicroRNA-30 family as gate-keepers in lung cancer
Authors: Kanthaje Shruthi , Baikunje Nandakishore , Kandal Irfan , Ratnacaram Chandrahas Koumar
Published: December 2021

Lung cancer is a prominent global health issue responsible for the highest fraction of cancer-related mortality. The disease burden has incited the investigation of associated molecular pathways, to explore better therapeutic possibilities. MicroRNAs are extensively studied in recent years for their pivotal role in the regulation of several tumorigenic pathways. MicroRNA-30 (miR-30) family is primarily investigated in case of non-small cell lung cancer (NSCLC) and has been found to play the role of a tumour suppressor. There are six members of miR-30 family: miR-30a, miR-30b, miR-30c-1, miR-30c-2, miR-30d and miR-30e. They regulate several imperative signalling pathways like p53, PI3K/AKT, resulting in the modulation of key carcinogenic events involving cell proliferation, apoptosis, metastasis, epithelial-mesenchymal transition, and drug resistance. Their altered levels are documented in NSCLC tissue and blood samples. They are suggested as biomarkers of disease progression and therapeutic outcomes in lung cancer. They possess immense therapeutic potential in the treatment of lung cancer and combat the emerging problem of drug resistance by modulating prime regulatory axes. However, there are many limitations in the existing studies, and additional research is required for the comprehensive understanding of pathways so that the tumour suppressive potential of miR-30 can be translated into clinical benefits. In this review, we present a deeper understanding of the regulatory role and clinical significance of miR-30 and have emphasized the emerging roles in lung cancer.
A short review on the influence of magnetic fields on neurological diseases
Authors: Funk Richard H. W. , Fähnle Manfred
Published: December 2021

This study reviews the use of magnetic and electromagnetic fields (EMF), pulsed electromagnetic fields (PEMF), and transcranial magnetic stimulation (TMS) in Parkinson’s disease, Alzheimer’s disease (AD), or Multiple Sclerosis (MS). The Introduction provides a review of EMF, PEMF, and TMS based on clinical observations. This is followed by a description of the basic principles of these treatments and a literature review on possible mechanisms describing the coupling of these treatments with biological responses. These response mechanisms include the cell membrane and its embedded receptors, channels and pumps, as well as signaling cascades within the cell and links to cell organelles. We also discuss the magnetic contribution to coupling EMF, as well as the recent finding of cryptochrome as a putative magnetosensor. Our conclusion summarizes the complex network of causal factors elicited by EMF such as those arising from the cell membrane via signaling cascades to radical oxygen species, nitric oxide, growth factors, cryptochromes and other mechanisms involving epigenetic and genetic changes.
Anti PD-L1 antibody: is there a histologic-oriented efficacy? Focus on atezolizumab in squamous cell non-small cell lung cancer
Authors: Gemelli Maria , Bidoli Paolo , Colonese Francesca , Canova Stefania , Cortinovis Diego
Published: December 2021

Squamous cell lung cancer (SqCLC) is the second most common histotype of non-small cell lung cancer (NSCLC) and is characterized by severe prognosis and lack of specific target agents. Atezolizumab is the first anti Programmed Death Ligand-1 (PDL-1) inhibitor approved for NSCLC patients of both histology in case of disease progression after first or further lines of therapy. Numerous studies are investigating the potential role of atezolizumab in different therapeutic setting, including SqCLC subtype. We searched for published clinical trials in Pubmed database, using the terms “atezolizumab”, “squamous cell lung cancer”, “NSCLC” and “non-small cell lung cancer”. We also searched for recently concluded and not yet published or ongoing trials in clinicaltrials.gov and in data from the latest international congresses. The aim of this review is to summarize current evidence on atezolizumab in SqCLC, from first line setting to novel potential indications from ongoing trials. Strengths and weaknesses of atezolizumab treatment were highlighted to speculate the role of this immune checkpoint inhibitor in novel future clinical scenarios.
Một số giải pháp quản lý công tác hướng nghiệp cho học sinh trung học phổ thông huyện Châu Thành, tỉnh An Giang
Authors: Trần Phú Hào
Published: December 2021

Giáo dục hướng nghiệp là một bộ phận của giáo dục toàn diện giúp mỗi học sinh có sự hiểu biết về tính chất của ngành nghề mà mình hướng tới, biết phân tích thị trường hoạt động và tháo gỡ vướng mắc hoặc rèn luyện bản thân. Từ đó, mỗi học sinh tự xác định được đâu là nghề nghiệp phù hợp hoặc không phù hợp với mình. Bài viết nghiên cứu những nguyên nhân dẫn đến việc học sinh ở 3 trường trung học phổ thông của huyện Châu Thành, tỉnh An Giang lựa chọn sai ngành nghề. Từ đó, tác giả nêu ra một số giải pháp quản lý công tác hướng nghiệp cho học sinh trung học phổ thông trên địa bàn huyện.
Thực trạng công tác giáo dục thể chất trong các trường tiểu học tại quận Bình Tân, thành phố Hồ Chí Minh
Authors: Mã Tấn Xuân , Nguyễn Quang Sơn
Published: December 2021

Qua khảo sát cho thấy thực trạng cơ sở vật chất và đội ngũ còn thiếu, chương trình giảng dạy môn thể dục còn nhiều bất cập, học sinh rất thích tập luyện thể dục thể thao và kết quả đánh giá thể lực của học sinh theo tiêu chuẩn rèn luyện thân thể có trên 97% học sinh đạt. Kết quả nghiên cứu làm cơ sở cho việc đề ra các giải pháp nâng cao chất lượng công tác giáo dục thể chất cho học sinh trong các trường tiểu học tại quận Bình Tân, Thành phố Hồ Chí Minh.
Nghệ thuật kiến trúc Miếu Thất Phủ tỉnh Vĩnh Long
Authors: Lê Hoàng Nam , Nguyễn Hùng Dũng
Published: December 2021

Miếu Thất Phủ tỉnh Vĩnh Long là một công trình nghệ thuật văn hóa vật thể đặc sắc của người Hoa trên địa bàn tỉnh nói riêng và trên đất nước Việt Nam nói chung, mang đậm nét văn hóa Trung Hoa cổ. Bài viết tìm hiểu sâu hơn về lịch sử, giá trị văn hóa, nghệ thuật kiến trúc ở Miếu Thất Phủ, từ đó giúp đọc giả có thể hiểu rõ hơn về tầm quan trọng của Di tích lịch sử - văn hóa Miếu Thất Phủ với lịch sử phát triển của địa phương, góp phần nâng cao ý thức của người dân trong việc tìm hiểu và giữ gìn,bảo tồn giá trị văn hóa địa phương.
Phát huy vai trò của ban chỉ đạo giảm nghèo trong thực hiện chính sách giảm nghèo bền vững trên địa bàn huyện Võ Nhai, tỉnh Thái Nguyên
Authors: Nguyễn Thị Linh
Published: December 2021

Giảm nghèo bền vững trên địa bàn huyện Võ Nhai được xác định là nhiệm vụ khó khăn, lâu dài, đòi hỏi cần có sự vào cuộc của cả cộng đồng, trong đó, ban chỉ đạo giảm nghèo các cấp có vai trò đặc biệt quan trọng. Tuy vậy, thực tế cho thấy có nhiều yếu tố chủ quan và  khách quan đã và đang làm ảnh hưởng tới hoạt động của ban chỉ đạo giảm nghèo. Trước yêu cầu của tình hình mới, cần phải có những giải pháp phù hợp khắc phục những hạn chế nhằm phát huy vai trò của ban chỉ đạo trong thực hiện chính sách giảm nghèo tại địa phương này.
Quản lý hoạt động giáo dục đạo đức nghề nghiệp cho sinh viên ngành giáo dục mầm non, Trường Đại học Đồng Tháp
Authors: Dương Huy Cẩn , Lê Hồng Cẩm Tú
Published: December 2021

Bài báo đề cập và phân tích thực trạng hoạt động giáo dục đạo đức nghề nghiệp cho sinh viên ngành Giáo dục Mầm non, Trường Đại học Đồng Tháp. Từ đó đề xuất một số biện pháp quản lý hoạt động giáo dục đạo đức nghề nghiệp phù hợp với điều kiện thực tế, có tính khả thi, góp phần nâng cao chất lượng giáo dục đạo đức nghề nghiệp cho sinh viên ngành Giáo dục Mầm non ở Trường Đại học Đồng Tháp đáp ứng yêu cầu đổi mới căn bản và toàn diện giáo dục đào tạo trong giai đoạn hiện nay.
Biện pháp quản lý đội ngũ giáo viên chủ nhiệm của hiệu trưởng trường trung học phổ thông huyện Châu Thành, tỉnh Sóc Trăng trong bối cảnh mới
Authors: Ngô Khánh Vy
Published: December 2021

Quản lý đội ngũ giáo viên chủ nhiệm lớp ở trường trung học phổ thông là một trong những biện pháp có ý nghĩa quan trọng để thực hiện mục tiêu giáo dục toàn diện cho học sinh. Xuất phát từ thực trạng quản lý đội ngũ giáo viên chủ nhiệm lớp, bài viết đề xuất các biện pháp quản lý đội ngũ giáo viên chủ nhiệm của hiệu trưởng các trường trung học phổ thông trên địa bàn huyện Châu Thành, tỉnh Sóc Trăng, đáp ứng yêu cầu đổi mới giáo dục trong bối cảnh hiện nay.
Ảnh hưởng của đòn bẩy tài chính và kinh doanh đa ngành đến hiệu quả kinh doanh của các hợp tác xã nông nghiệp ở Việt Nam
Authors: Đoàn Vinh Thăng
Published: December 2021

Nghiên cứu này đánh giá ảnh hưởng của đòn bẩy tài chính và kinh doanh đa ngành đối với hiệu quả kinh doanh của các hợp tác xã nông nghiệp (Khu vực I) tại Việt Nam. Dựa trên dữ liệu thu thập từ 3.584 hợp tác xã thuộc Khu vực I, kết quả ước lượng bằng mô hình hồi quy (OLS) chỉ ra rằng, mức độ sử dụng đòn bẩy tài chính có ảnh hưởng tích cực lên hiệu quả kinh doanh, đại diện bởi hệ số ROA. Tuy nhiên, khi tỉ lệ vốn vay trên tổng tài sản cao hơn mức 42,5% thì sự gia tăng đòn bẩy tài chính sẽ làm giảm hệ số ROA. Ngoài ra, kết quả còn cho thấy các hợp tác xã kinh doanh đa ngành sẽ có hiệu quả cao hơn so với các hợp tác xã không đa dạng hóa ngành nghề kinh doanh.
Tương tác của Zn với hai vô hướng trong mô hình 3-3-1-1
Authors: Trịnh Thị Hồng , Lê Thị Tuyết Dung
Published: December 2021

Sự thống nhất ZN sẽ trộn với các boson chuẩn của đối xứng 3-3-1 và tham gia vào các quá trình điện yếu như chúng ta đã biết. Sự tồn tại của ZN gắn với các đóng góp nhỏ và có thể cho giải thích những sai lệch của mô hình chuẩn. Như một ví dụ quan trọng, sự đóng góp của ZN  đối với các quá trình sinh và rã Higgs ở LHC (Large Hadron Collider) gần đây có thể cho giải thích các dị thường về các đại lượng đo lường Higgs. Bản thân ZN là một kênh khám phá cho vật lý mới ở LHC. Mô hình 3-3-1-1 cung cấp một cơ chế Higgs mới và có thể cũng góp phần cho giải thích về tự nhiên của Higgs, đồng thời dự đoán các hạt Higgs mới trong đó có cả vật chất tối. Chúng tôi khảo sát tương tác của ZN với các hạt vô hướng của mô hình 3-3-1-1.
Nghiên cứu chế biến nước uống từ quả gấc và quả chanh dây
Authors: Nguyễn Thị Huỳnh Như , Phạm Hà Thanh Nguyên
Published: December 2021

Nghiên cứu sử dụng thịt quả gấc làm nguyên liệu chế biến nước giải khát kết hợp với chanh dây góp phần tăng giá trị thương phẩm cho hai loại quả này cũng như phát triển sản phẩm mới trên thị trường. Quá trình nghiên cứu nhận được: tỉ lệ phối chế 15% dịch chanh dây, 10% thịt gấc, đường 18oBx sản phẩm được đánh giá có màu sắc, mùi vị ưa thích. Chế độ thanh trùng: nhiệt độ càng cao thời gian giữ nhiệt dài, sản phẩm xuất hiện mùi nấu chín, tổn thất vitamin C càng cao. Vì vậy, kết quả chọn nhiệt độ thanh trùng 85oC, thời gian giữ nhiệt 6 phút, giá trị thanh trùng P=9,88, cho sản phẩm phù hợp, đảm bảo được an toàn vệ sinh thực phẩm.
Multilevel Marketing: Inner Workings, Socioeconomic Effects and the Islamic Juridical View
Authors: Alrahawan Mohammad
Published: December 2021

The intent of this article is to highlight the origins and development of multilevel marketing, its inner workings, and Islamic juridical views on its activities. One group of Muslim scholars permits it while others forbid it. The view forbidding it is the majority opinion. The juridical viewpoint forbidding multilevel marketing is more convincing than the view permitting it because of research-based evidence highlighting the reality of its inner workings, its socioeconomic harms and stronger juristic arguments opposing it. The inner workings of multilevel market reveal why the majority opinion forbids this so-called business model. This article aims to introduce a sharia-compliant version of the multilevel marketing model which may align with the Islamic perspective.
مبدأ " العدول " عند الأصوليين وأثره في معالجة نوازل (وباء كورونا )
Authors: الريسوني قطب
Published: December 2021

يروم هذا البحث استجلاء السياق الاصطلاحيِّ والتاريخيِّ لمبدأ "العدول" عند الأصوليين"، وربطه بالمدارك الاجتهادية الاستثنائية التي انبثق من رحمها، كالاستحسان وسدّ الذرائع. أما الجانب التطبيقي فدار على بيان أثر هذا المبدأ الاجتهادي في معالجة نوازل كورونا واستيعاب تحدياتها النوازلية في إطار ما يكفله من الانزياح عن القواعد المطردة والأقيسة الجزئية نظراً إلى المآل وتنزيلاً على وزانه. وقد توسل الباحث بالمنهجين الاستقرائي والتحليلي، فكان الأول مطيته في تتبع اللمع الأصولية ذات النسب بمبدأ العدول، وتقري التطبيقات النوازلية الكاشفة عن إعماله في الاجتهادات والفتاوى، وكان الثاني مطيته في تحليل الأبعاد الاجتهادية الاستثنائية لهذا المبدأ، وكشف معالم تنزبلها في النماذج المنتخبة. ومن النتائج المتأدى إليها: أن نوازل الوباء ألفت متنفسها في سياق مبدأ استثنائي محكوم بتوابع التنزيل وخصوصيات الزمان والمكان؛ ذلك أن الوفاء بحاجات الناس في زمن الشدة والضيق، يقتضي من المجتهد- في أحيان كثيرة- الاستثناءَ من القواعد العامة، والعزوفَ عن الأقيسة الصماء، لتغليب ما يراه راجحاً في ميزان الشرع والمصلحة معاً، وهذا ما ارتسمه المفتون في معالجة نازلة تعجيل الزكاة، ونازلة منع المصافحة، ونازلة تعديل الثمن في عقود المقاولات المتراخية، وغير هذا وذاك مما أُفتي فيه إفراداً وجمعاً، وشُدَّ على حبلٍ متينٍ من مقاصد الشريعة، ونعم الحبلُ إذا استحرّت وتيرة النوازل، ولجّ داعي الاجتهاد.
التفسير المادي للقرآن الكريم – الاستمداد والإمداد تفسير الهداية والعرفان في تفسير القرآن بالقرآن أنموذجا
Authors: سعد الخطيب أحمد
Published: December 2021

مر التأليف في تفسير القرآن الكريم بمراحل عدة، أنتجت مناهج واتجاهات في التفسير، أكثرها كان علميا محمودا، وبعضها كان مذموما، إما لتأثره بمذهبية أو إيديولوجية يستمد منها منهجه في التفسير، أو لتعصبه لاتجاه ٍسياسي ونحوه ساعد على الانحراف بالتفسير عن مساره، وأدى إلى الانجراف نحو تيارٍ ما هكذا نستطيع القول: إن أدلجة التفسير وجعله أسير المذهبية والتعصب، قد بدأ مبكرا في القرن الثاني الهجري على يد المعتزلة، وفي العصر الحديث حاول بعض المحدَثين الذين انبهروا بالعلوم الحديثة وبنجاحها في تفسير بعض الظواهر الكونية، إلى جعل نظريات الفيزياء وسائر العلوم التطبيقية حاكما على تفسير القرآن الكريم، فقادهم هذا إلى إنكار المعجزات التي أيد الله بها أنبياءه ورسله، وتعسفوا في تأويلها، انتصارا لقوانين الطبيعة ونظرياتها، التي أثبتها العلم الحديث، ومن هؤلاء محمد أبو زيد الدمنهوري، الذي كتب تعليقات موجزة على هامش المصحف الشريف، وسماها الهداية والعرفان في تفسير القرآن بالقرآن، فأنكر فيه معجزات الأنبياء وأنكر وجود الملائكة والجن، وقام بتأويل كل الآيات الواردة في ذلك تأويلا ماديا، ولمناقشته كان هذا البحث.
التأصيل الشرعي لسلطة ولي الأمر في الإلزام بالحجر الصحي
Authors: عمر يوسف
Published: December 2021

يهدف البحث إلى بيان التأصيل الشرعي للحجر الصحي في الحد من انتشار الأوبئة والأمراض المعدية، وذلك لأن الدول لجأت لتطبيق إجراءات إحترازية تقيد الحرية الشخصية كالحجر الصحي، وذلك لمقاومة الوباء السريع الانتشار المسمى بفيروس كوفيد 19، فبين الباحث التأصيل الشرعي للحجر الصحي، ومدى سلطة ولي الأمر في الإلزام بالحجر الصحي، وإثبات مشروعية عقاب المخالفين للحجر الصحي. فأنتظم البحث في ثلاثة مباحث: تكلمت في المبحث الأول عن تعريف الحجر الصحي ونشأته وضوابطه، وأما المبحث الثاني فبينت فيه التأصيل الشرعي للحجر الصحي، وخصصت المبحث الثالث للتأصيل الشرعي لسلطة ولي الأمر في الإلزام بالحجر الصحي.
Մարտիրոս Սարյանի «Գիսաստղը»
Authors: Մկրտչյան Մանե
Published: December 2021

Martiros Saryan’s "Fairy Tales and Dreams" series, in terms of the subject matter, pictorial language and aesthetic views, fully corresponds to the art of the younger generation of Russian Symbolism. The artist’s work of that period is characterized by mysterious plots, “wandering” images and recurring themes, giving rise to various interpretations. Such is "Comet", created in 1907. The key to the symbolism of this work is semantic analysis of the one-eyed figure and that of the gazelle, which are central to the composition. Some of Saryan’s notes and the parallels with the symbolistic thinking of the time, allow us to conclude that the gazelle symbolizes Nature as the Creator, while the one-eyed figure embodies Poet with universal knowledge. Martiros Saryan’s "Comet" asserts the unbreakable bond between Nature and Man, the artist's love and respect for nature and faith in man.
Use of External Approach for Severe Genu Valgo Knee Arthroplasty
Authors: Cabrera Sebastián Rosero , Gallardo William Pinzón , Rico Helberth Augusto González , Gómez Carlos Fernando Bastidas , Medina Tulio Sotomayor , Robles Andrea Carolina Wilcox , Moris Decknia Luz Vásquez , Tejeda Carlos José González
Published: December 2021

The deformities of the lower limbs (genu valgus and genu varus) are alterations frequently developed properly by physiological processes which usually disappear at 2 years (genu varus) and at 7-8 years (genu valgus), being considered in adults normal a 4º-6º genu valgus, however the appearance of the latter is also related to various metabolic pathologies, tumors, traumatic sequelae, infections, skeletal dysplastic and idiopathic genu valgus. In the bibliography, there is a greater consensus on the approach to varus deformity, not so in valgus deformities, where there is no bibliography with a level of evidence that defines established protocols to treat severe valgus deformities>20, currently good treatment results have been demonstrated by means of knee arthroplasty to correct genu valgus deformities, which showed good results in the alignment of the lower extremities through the balance of ligaments in patients with severe genu valgus with pain reduction. , improvements in knee function and with a low rate of complications, the use of these alternatives such as the external approach in total knee replacement in patients with severe genu valgus and medial collateral ligament insufficiency allows correcting large deformities using a technique simple and in most cases without the use of a prosthesis that generates a degree of constraint, progressively improving their living conditions.
TO THE QUESTION OF MULTIPROFILE USE GAS RESOURCES COAL DEPOSITS OF DONBASS
Authors: Bulat A. , Pymonenko L. , Pymonenko D.
Published: December 2021

The coal mining in Ukraine allows to receive and use various alternative gas resources. In article questions extending nitrogen in carboniferous deposits of the Western Donbass, Lviv-Volyn basin is considered, to take into attention the high content of nitrogen on the surveyed sites common review possibilities use given resource at the enterprises mining-metallurgical complex is made.
GAS PRESENCE OF THE COAL SEAM n8 OF THE LVIV-VOLYN BASIN
Authors: Buchynska I. , Yavny P. , Shevchuk O.
Published: December 2021

In the paper we have demonstrated the description of the structure, gas presence and methane content of the coal seam n8 of the Lviv-Volyn Basin. The map of its natural gas presence has been compiled. Executed studies have allowed us to distinguish the areas promising for possible methane extraction.
TECTONIC FEATURES OF MONOCLINES AT THE JUNCTION ZONE OF DNIEPER-DONETS SEDIMENTARY BASIN IN VIEW OF IDENTIFYING UNCONVENTIONAL HYDROCARBONS
Authors: Okrepkyi O. , Karpenko I.
Published: December 2021

Currently unconventional gas is considered to be coal bed methane, shale gas and tight gas. In our opinion, to this list should be added gas deposits controlled by inner surface unconformities in sedimentary rock complexes. Despite signs of «traditional» reservoirs – corresponding structural forms and others, specific features of their occurrence (under and above the unconformities with predominance of lithologic and stratigraphic factors in the formation of traps) can attribute them to unconventional gas. Even though there are all prerequisites to consider them as common types of deposits, they do not still refer to in integer directed search process. Add to this that these types of traps may also be characterized by the presence of «unconventional» gas properties such as low permeability, porosity, etc.
THE DESTRUCTION OF FLUID SATURATED COMPRESSED GEOMATERIAL
Authors: Bulat A. , Pylypenko Yu.
Published: December 2021

The investigation results of changes of the physical-mechanical and reservoir geomaterial properties of fluid saturation different degrees in the limit and beyond limit deformation area were given. The influence of the speed of longitudinal and transverse strains on changing of the strength and deformation parameters of coals and rocks, depending on the type of fluid and the value of the lateral overpressure at different energy costs of destruction was established. The approximation of filtration parameters changing curves by parametric splines under destruction was represented.
IMPROVING THE METHOD FOR DETERMINING THE LOAD ON THE WORKING FACE ON THE GAS FACTOR
Authors: Starikov G. , Pilyugin V. , Zavrajhin V. , Kolchik I. , Vasilkovsky V. , Mamleev Sh. , Mamleev Sh.
Published: December 2021

The paper contains an improved basis for the forecast of the kinetic parameters of the evolution of gas from the coal mass and ruined coal to determine the load on the working face based on the physical properties of the coal seam and technological parameters of its recesses.
MODERN METHODS OF INVESTIGATION PHASE AND ELEMENTAL COMPOSITION OF THE CORE
Authors: Smirny M. , Epishev M.
Published: December 2021

Successful problem solving design and optimization techniques hydrocarbon largely depends on the mineralogical composition of reservoir rocks. It mineralogical composition directly determines the applicability of certain methods of treatment reagent wells are needed, such as shale gas. In this article we have shown excellence and effectiveness of the X-ray diffraction analysis in combination with elemental analysis for problems of geological services.
ABOUT GEOLOGICAL, NOOSPHERE AND SOCIAL COMPONENTS OF MODERN ECOLOGICAL SECURITY OF UKRAINE
Authors: Radzivill A. , Liventseva G.
Published: December 2021

Rational and comprehensive development of Coal and Gas Deposits will improve the environmental safety of the coal-mining regions and, as a consequence, to reduce Ukraine’s energy dependence on imported gas.
Bobble Head Doll Syndrome: what have we described in the scientific literature?
Authors: Souza Felipe dos Santos , Rivelli Alvaro Moreira
Published: December 2021

Introduction: The bobble head syndrome (BHDS) is described in the literature as a complex and rare syndrome with repetitive movements of the anteroposterior head. Furthermore, it is known that this movement disorder is due to the effect of pressure from the third dilated ventricle, which distorts the red dorsomedial nucleus and the dentatorubrotalamic pathways. Objective: to evaluate the number of studies on the syndrome and, added to the findings, describe the manifestations about the Bobble Head Doll Syndrome, elucidating the main neurological exams, treatments used and reported prognoses, in order to make it a potential diagnosis in children who present a compatible clinic. Methodology: a systematic review based on databases (SCIELO <LILACS and PUBMED), using the PRISMA method with the following descriptor: Bobble Head Doll Syndrome. The selection criteria included: studies made available in full, case reports, reviews and clinical trials. Exclusion criteria: articles not available in full, duplicates and works that only touched on the theme. Results: it was found in the scientific literature, PUBMED: 52 studies and SCIELO: 0. SCIELO: 2. Conclusions: the articles selected based on the established criteria showed a significant scientific scarcity around the Bobble Head Doll Syndrome. The dissemination of new studies and documentation of case reports is essential in understanding both the general syndrome and the specific knowledge of the procedures in which neurologists must take it. In this sense, the epidemiology is approximately between 2 and less than 5 years of age in children.
Expanding the neurological and imaging phenotype of women with adult-onset X- linked Adrenoleukodystrophy.
Authors: Pinto Wladimir Bocca Vieira de Rezende , Badia Bruno de Mattos Lombardi , Farias Igor Braga , Albuquerque Filho José Marcos Vieira de , Machado Roberta Ismael Lacerda , Souza Paulo Victor Sgobbi de , Oliveira Acary Souza Bulle
Published: December 2021

Background: X-linked Adrenoleukodystrophy (X-ALD) represents a key inherited metabolic disorder in neurological practice, representing an important differential diagnosis in different neurological contexts. Symptomatic female patients have been scarcely studied in large cohorts. Objectives: Evaluation of clinical, laboratory and genetic findings from a Brazilian cohort of women with X-ALD. Methods, design and setting: We performed a retrospective observational study of clinical, biochemical, genetic, neuroimaging and neurophysiological aspects of 10 Brazilian female patients with X-linked Adrenoleukodystrophy under clinical follow-up at the Neurometabolic Unit, Division of Neuromuscular Diseases, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. Results: Mean age at diagnosis was 46.2 years and at symptom-onset was 39 years. Female patients presented with spastic paraparesis and neurogenic bladder (60%), cognitive decline (50%), demyelinating sensorimotor polyneuropathy (40%), cerebellar ataxia (30%), epilepsy (20%), apraxia and psychotic symptoms (10%). The most common misdiagnosis were Primary Progressive Multiple Sclerosis and Hereditary Spastic Paraplegia. The main neuroimaging findings were corticospinal tract hyperintensity and cervical and thoracic spinal cord atrophy (60%), unspecific white matter changes (40%) and typical parieto-occipital leukodystrophy. All patients had abnormal profiles of plasma very-long chain fatty acids, all with elevated C26 levels and 80% with elevated C24 levels, but all with abnormally raised C26:C22 and C26:C24 ratio. The most common pathogenic variant observed was c.311G>A (p.Arg104His) (60%). Conclusions: Female patients with ABCD1 pathogenic variants must be carefully evaluated for neuropsychiatric disturbances and followed-up until elderly due to the common occurrence of variable motor, autonomic and sensory compromise.
Emerging therapies for amyotrophic lateral sclerosis applied to drug discovery
Authors: Albuquerque Pedro José Honório de , Lopes Laura Guerra , Carvalho Jordy Silva de , Lima Luzilene Pereira de , Pitta Marina Galdino da Rocha
Published: December 2021

Background: Amyotrophic Lateral Sclerosis (ALS) is a progressive neuromuscular disease mainly caused by genetic disorders. This progressive disorder involves the degeneration of motor neurons at various levels. Drugs have been studied, and they show improvement in survival and reduced progression of the disease, they are riluzole and edaravone. Objectives: Investigate emerging therapies for the treatment of ALS. Methods: The Pubmed database was used to conduct the research, and the keywords were “Amyotrophic Lateral Sclerosis”, “Emerging”, “Therapies”,”Drugs”, all present in Mesh. Articles from 2016 to 2021 were used. And the survey was conducted on May 2, 2021. Results: Only two drugs have been approved yet by the Food and Drug Administration for the treatment of ALS, riluzole and edaravone, and each one offers modest benefits in mortality and/or function. On the other hand, 88 studies of clinical intervention trials are active using different drugs. Current therapies under development include oral tyrosine kinase inhibitors (masitinib, trametinib); the antisense oligonucleotide (tofersen); the human monoclonal antibody inhibitor (ravulizumab); and mesenchymal stem cells (MSC); among others (RT001, Enoxacin, Engensis, ANX005, Deferiprone). Conclusions: Due to gaps in the knowledge of the specific pathophysiology of ALS, the definitive treatment is still a mystery. The drugs currently in use, riluzole and edaravone, are the most promising in terms of delaying the progression of the disease.
Trigeminal rhizotomies in the treatment of trigemium neuralgia
Authors: Przysiezny Bernardo , Haas Leandro José , Staedele Guilherme Voltolini , Dummer Carlos Henrique , Soares Matheus Durieux , Cobra Fernanda Jacobsen , Hessmann Julia Dummes , Schuster Anna Lydia , Lima Caroline Barbosa , Wandall Guilherme , Severino Wesley , Silva Laura Moll , Schlindwein Lucas , Walzburger Bryan Renan , Sanches Bruno Menegatti , Domingos João Pedro Latrônico , Simones Julia , Mees Wallace , Sanches Jacqueline Dulce Yumi , Meurer Gabriel Machura , Scheidt Gabriela
Published: December 2021

Background: Rhizotomy is a procedure that seeks to interrupt, the pain function of sensitive nerves. Trigeminal Neuralgia (TN) is a disease that can benefit from a trigeminal rhizotomy. Currently, percutaneous trigeminal radiofrequency rhizotomy and balloon microcompression techniques are widely used. Objective: To expose therapeutic experience of TN by trigeminal rhizotomy therapy. Methods: Retrospective study of TN patients undergoing trigeminal rhizotomy in a reference service in endovascular neurosurgery in Blumenau, Santa Catarina, from 2009 to 2019. The variables analyzed were gender, age, symptoms, comorbidities and procedural characteristics. Results: 39 patients were analyzed, 24 were women (61.5%) aged between 33 and 84 years and a mean of 62.8 years old. Regarding the symptoms presented, the most prevalent was headache (69.2%), followed by paresthesia (10.2%), tinnitus (7.7%) and dizziness (5.1%). For comorbidities, 25.6% had systemic arterial hypertension and 15.4% had dyslipidemia. The trigeminal branches most involved in rhizotomies were V2-V3 (56.4%), followed by V2 (28.2%), V1 (7.7%), V1-V2 (5.1%) and V3 (2.5%). The left side was more affected (56.4%). The percutaneous approach was performed in all patients, in 92.3% the balloon technique was performed and in 7.7% radiofrequency was used. In 79,5% of the cases, it was possible to accomplish the treatment with only one session. Conclusion: The approach of TN through rhizotomy proved to be a technique with low morbidity, reaffirming the good results of therapy. The monitoring of cases is essential to allow a better assessment of the long-term effectivenes of the treatment.
Leprosy prevalence, grade II rate of physical disability and proportion of multibacillary cases: A paradox that shows late diagnosis and hidden prevalence?
Authors: Santos Lucas Gomes , Leal Thiago Cavalcanti , Silva Leonardo Feitosa da , Armstrong Anderson da Costa , Carmo Rodrigo Feliciano do , Paiva João Paulo Silva de , Santana Gibson Barros de Almeida , Albuquerque Antônio Leopoldo do Nascimento Gama , Matos Thais Silva , Rocha Carlos Alberto de Oliveira , Souza Carlos Dornels Freire de
Published: December 2021

Introduction: In the last decades the number of leprosy cases has been decreasing in the world. This reduction has been questioned by researchers who believe there are more patients. Objectives: To analyze the temporal evolution of three epidemiological indicators (prevalence rate, grade II rate of physical disability and proportion of multibacillary cases) in order to find evidence of late diagnosis and hidden prevalence of leprosy in the state of Bahia, Brazil. Design and setting: This is an ecological study of time series. The unit of analysis was Bahia, Brazil. Methods: The data were obtained the DATASUS platform (http://datasus. saude.gov.br/). The inflection point regression model (joinpoint) was applied to assess the trend of the indicators from 2001 to 2015. The significance level of 5% and 95% confidence interval(95% CI). Results: There was a tendency to reduce the prevalence (AAPC -5.5%;p <0.001) accompanied by an increase in the rate of grade II (AAPC 2.7%; p <0.001). The presence of disabled individuals in the diagnosis, in addition to signaling for the late detection of the case, reflects the transcendence of the disease, that is, its social value. Finally, there was an increase in the proportion of multibacillary cases, increasing from 48.8% at the beginning of the time series to 66.5% at the end of it (AAPC 2.2%;p <0.001). Conclusions: This paradox suggests the existence of a late diagnosis and hidden prevalence in the state. Thus, the need to implement actions that make the diagnosis of new cases, reinforcing the hidden burden of leprosy and transmission, is reinforced.
Rehabilitation in traumatic brain injury due to automobile accident
Authors: Falcão Rafael Tenório , Arruda Alexandre Gabriel Taumaturgo Cavalcanti , Horta Wagner Gonçalves , Vieira Douglas de Albuquerque Veiga , Silva Guilherme de Souza
Published: December 2021

Background: Automobile accidents (AA) stand as public health issue, being the second most prevalent cause of preventable unnatural death in Brazil. Traumatic brain injury (TBI) has a strong relationship with AA, with a high incidence of morbidity and mortality. Due to the wide spectrum of possible sequel, rehabilitation is essential to help patients to restore functionality and improve quality of life. Objectives: We sought to evaluate and characterize rehabilitation in cases of TBI, resulting from AA. Design and setting: This is an integrative literature review carried out by medical students from the University of Pernambuco. Methods: The databases BVS, PubMed and SciELO were used in this research together with the following descriptors: “Prognosis”, “Accidents, Traffic”, “Brain Injuries, Traumatic” and “Rehabilitation”. The focus was on articles published in Portuguese, Spanish and English between the years 2011 and 2021. Among the 44 articles found, only 06 were suitable to the research. Results: When compared the results of rehabilitation in specialized unit and those in non-specialized unit there were notable difference. Despite the longer hospital stay, the specialized units allowed for better recovery and greater functional independence for their patients. It was made clear that, even in cases of mild TBI, rehabilitation minimized functional impairments and improved recovering patient’s quality of life. Conclusions: It is necessary to expand the specialized units for better rehabilitation of patients with TBI, due to the treatment place being a major component in the process. The specialized units demonstrated considerable efficiency when compared to the non-specialized units.
Fibrinolytic therapy in the treatment of pediatric ischemic stroke
Authors: Ferreira Hanna dos Santos , Silva Agata Layanne Soares da , Peres João Lucas de Sousa
Published: December 2021

Introduction: Pediatric stroke is a disorder that can result in morbidity and mortality. The ischemic type is the most common and has thrombolytics as the preferred therapy. Objective: To evaluate the therapeutic management and efficacy of fibrinolytics in pediatric patients with ischemic stroke. Methodology: The literature review was carried out in PUBMED, MEDLINE, Embase databases, with the descriptors “Fibrinolytic Agents”, “Thrombolytic Therapy”, “Ischemic Stroke”, “Stroke”, “Pediatrics” and “Treatment”. Included were clinical trials, randomized controlled trials, cohort, case- control, and case series in English or Portuguese published in the last 5 years. It gathered 8 articles. Results: Treatment in the acute phase and for secondary prevention in the chronic phase of pediatric stroke are antithrombotic therapies and platelet antiaggregants, commonly aspirin. Comparing the latter and low molecular weight heparin, neither has shown superiority in preventing stroke recurrence. Without good evidence, however, aspirin is indicated for idiopathic stroke and anticoagulants in cardioembolic stroke by some guidelines. In recombinant tissue plasminogen activator therapy in one paper it was suggested there is more risk for conversion to hemorrhagic events compared to untreated, but in another paper hemorrhage was not seen. There was high mortality with this therapy and higher chances of being discharged to short term hospital, skilled nursing facility or intermediate care facility. In endovascular therapy, delay in diagnosis limits its use and stroke complications did not differ between patients who did or did not undergo this therapy. Conclusion: Further studies are needed to evaluate the efficacy of fibrinolytics.
Burkitt Lymphoma in a HIV infected patient with involvement of cranial nerves
Authors: Scherer Clara Sasse , Zattar Aléxia , Bayerl André , Fileti Maria Eduarda Angelo de Mendonça , Oliveira Raddib Eduardo Noleto da Nóbrega de , Guimarães Rafael Pereira , Nunes Thábata Emanuelle Martins , Ribas Gustavo da Cunha , Moro Carla Heloísa Cabral , Longo Alexandre Luiz
Published: December 2021

Context: Burkitt Lymphoma (BL) is a highly aggressive type of nonHodgkin’s (NHL) B-cell lymphoma and it’s rare in adults. The incidence is increased in those infected with the Human Immunodeficiency Virus (HIV). Endemic, sporadic, and associated with immunodeficiency are its subtypes. The disorder manifests with adenomegalies in several regions, including the Nervous System, and, when cranial nerves are affected, III and VII pairs are more involved. This study aimed to report on a rare case of IV and V cranial nerves pairs involvement caused by BL in a patient with immunosuppression due to HIV infection. Case report: S.A.R., 57 years old, female, diagnosed with HIV and in antiretroviral therapy sought assistance at a public hospital in Joinville. Right axillary lymph node enlargement since 03/20 with biopsy showing atypical lymphocytic infiltrate. On 09/20, she started with perioral paresthesia followed by crises of throbbing right hemicranial headache with dental arch irradiation. Later, she was admitted to the hospital with diplopia for 3 days, night sweats, and unintentional weight loss (2 kg). Skull Magnetic Resonance showed a small periventricular gliosis area and mastoiditis on the right. Main diagnostic hypothesis of BL with trigeminal neuralgia and trochlear palsy on the right. Referred to the intensive care unit, she entered in cardiorespiratory arrest and died. Conclusion: LB evolves rapidly and represents 1 /3 of NHL cases in HIV patients. Despite being an uncommon disease in adults, it’s important to be included in differential diagnosis in clinical presentations, as in the case reported.
Analysis of hospitalizations for Parkinson’s disease and the role of primary health care in patient care
Authors: Sousa Marianna Ramalho de , Ávila Beatriz da Silva , Moreira Caique Nunes , Oliveira Carla Resende Vaz , Souza Laura dos Santos de , Pereira Carolina Monte Santo Burdman , Gonçalves Michelly Hellem Alves de Freitas , Chenu Anne Claire , Durans Thamires Macedo , Rabelo Larissa Barros Assumpção , Ribeiro André Elias
Published: December 2021

Introduction: Parkinson’s disease (PD) is a neurological disorder that affects the dopamine-producing neurons and affects the patient’s movements. According to the World Health Organization, about 1% of the world’s population aged 65 years or older has PD. The study aims to analyze the hospitalizations for Parkinson’s disease in Brazil and highlight the importance of primary health care (PHC) in the care of these patients. Methods: This is an integrative literature review, using articles from the Pubmed and Medline databases, as well as the DATASUS database from January 2017 to January 2021. The descriptors used were: “Parkinson’s Disease”; “Comprehensive Health Care”; “Patient-Centered Care”. Results: In the period analyzed there were 3.536 hospitalizations for PD in Brazil with spending of R$14,937,372.3 highlighting the Southeast region that represents 49% of the total of these. Regarding sex, age and self-reported color/race, the most affected are men with 60.6%, individuals between 60 and 69 years (26.3%) and whites (49.9%). A total of 218 deaths were registered, with a mortality rate of 6.1%. Discussion: The PHC is responsible for part of the diagnosis and monitoring of patients with PD, being a central part in the coordination of care. It acts through the levels of care and improves the quality of life of its users through health actions, thus improving their quality of life. Conclusion: Basic health units must improve themselves through the continuous training of the professionals involved, thus resulting in a decrease in the mortality rate.