bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI KOMUNIKASI PEMASARAN PARIWISATA DI MASA PANDEMI COVID-19 (TOURISM MARKETING COMMUNICATION STRATEGY IN THE COVID-19 PANDEMIC PERIOD)
Authors: SARASWATI1 HESTI DWI , Afifi Subhan
Published: March 2022

Pandemi Covid-19 memberikan dampak yang sangat signifikan terhadap industripariwisata. Menarik untuk mengkaji bagaimana pemerintah daerah mengembangkanstrategi komunikasi pemasaran di masa krisis, untuk memulihkan sektor pariwisata diera new normal. Penelitian ini bertujuan untuk mengeksplorasi dan menganalisisstrategi komunikasi pemasaran pariwisata di masa Pandemi Covid-19 yangdilaksanakan oleh Dinas Pariwisata dan Kebudayaan, Kabupaten Majalengka.Penelitian ini menggunakan paradigma interpretif dengan pendektan deskriptifkualitatif dan studi kasus sebagai metodenya. Data dikumpulkan melalui wawancaramendalam kepada para narasumber yang berkompeten dengan perencanaan danimplementasi strategi komunikasi pemasaran pariwisata. Selain itu, datadikumpulkan melalui observasi dan analisis dokumen terkait. Hasil penelitianmenunjukan bahwa strategi komunikasi pemasaran pariwisata di masa pandemiCovid-19 yang dilakukan oleh Dinas Pariwisata dan Kebudayaan, KabupatenMajalengka, mengacu pada aktivitas komunikasi pemasaran yang menggabungkankonsep bauran pemasaran pariwisata (tourism marketing mix) dan konsep bauranpromosi (promotion mix). Pelaksanaan komunikasi pemasaran pariwisata Majalengkamenggunakan konsep bauran promosi yang terdiri dari advertising, personal selling,public relations, sales promotion dan pemanfaatan media sosial. Studi inimemberikan kontribusi akademik berupa tambahan referensi terkait komunikasipemasaran di masa krisis dengan konteks pariwisata lokal.
ГРАФИЧЕСКАЯ ПРЕЗЕНТАЦИЯ ПАРЦЕЛЛИРОВННЫХ КОНСТРУКЦИЙ В ЯЗЫКОВОЙ СТРУКТУРЕ РОМАНА А. БЕЛОГО «ПЕТЕРБУРГ»
Authors: ALIYEVA Elvina
Published: March 2022

В статье впервые проводится анализ графической презентации парцеллированных конструкций на материале языка произведения А. Белого «Петербург», выявляется ее своеобразие. Анализ графической презентации данных конструкций позволил выявить различные типы структур, графические символы, своеобразие включения их в текст. По количеству в конструкции парцеллятов выделяются однозвенные и многозвенные структуры, среди которых преимущественно используются первые. Пунктуационное оформление разделительных пауз между базовой частью и парцеллятом, между парцеллятами, а также в конце парцеллированной структуры представлено 7 графическими символами однозвенных структур и 6 — многозвенных
структур. Всего в языковой структуре романа выявлено 13 графических символов парцеллированных конструкций. По соотношению распространенности базовой части и парцеллята были выделены два типа конструкций, в которых: а) преобладает объем базовой части; б) преобладает объем парцеллятов. Включение в текст также имеет свои особенности: последовательное расположение частей конструкции; выделение парцеллята или парцеллятов в абзацы, либо дистанцированное расположение парцеллятов от базовой части. Делается вывод, что графическая презентация парцеллированных конструкций способствует выразительности и экспрессивности повествования.
Disaster Sites Roaming Smart Car with Hand Gesture Controller
Authors: Zapiee Mohd Khuzaimi , Mohana Dharnishaa , Balasingam Sheshalani , Panessai Ismail Yusuf
Published: March 2022

This research is about an Internet of Things (IoT) project and research about smart car development. IoT is machine or device that can transfer data over a network without a connection between human-to-human or human-to-device interaction. One of the significant of IoT is the revolution of smart car. This project is a research about smart car that help civilian in distress that have been caught in a natural disaster like land slide or even an earthquake and traps in a collapsed building or it can be a smart car that can recon the site. This smart car can assist the rescue squad to detect that survivor by going through the small hole that been create by the collapsed building and give the rescue squad the where about of the survivor and provide information to the rescuer about the site. The smart car also have solar system to power the system and can run longer than powered only with battery. The smart can also have anti capsize that may make the smart car overturn in the disaster site while roaming in the disaster to detect the victims. This feature help the smart car easily to roam freely with the unstable environment. The smart car also provided with camera for the rescue squad to analyse the structure in the disaster and avoid to dig the rubble or disaster site and killed the victims and the user can gain the insight of the site and gain information more detailed. The smart car can be controlled with a globe type controller for easier the user to control the smart car in the unstable and fragile site.
WILSON’S DISEASE PRESENTING AS COOMB’S TEST NEGATIVE HEMOLYTIC ANEMIA
Authors: Sarvodey Shyam , M Manini , N Mothi S , BR Srirama , Darla H Tanishka
Published: March 2022

Wilson’s Disease (WD) is an autosomal recessive genetic disorder associated with excess storage of copper in liver, brain and other organs. Wilson
’s disease could be fatal if not diagnosed early and not treated. We report a 10year old female case presenting with discoloration of eyes, dark urine,
generalized itching with loss of appetite and nausea turned out to be Wilson’s disease presenting as Coomb’s test negative Hemolytic Anemia and
comorbid Rickettsial fever. Slit lamp examination revealed Kayser-Fleischer ring around the cornea, and 24-hour urinary copper and serum
ceruloplasmin conrmed the diagnosis. Treatment aimed at preventing accumulation of copper in tissues and reducing already accumulated copper
in the body. A combination of copper chelators like D-penicillamine and zinc therapy is used to prevent progress of WD. She was started on DPenicillamine with Zinc supplements and Tablet Doxycycline for Rickettsial fever. Prognosis and possibility of requirement of Liver
transplantation at later stage of life explained to the attenders.
FIXATION OF FRACTURE SCAPHOID WITH HEADLESS COMPRESSION SCREWA PROSPECTIVE STUDY ASSESSING FUNCTIONAL OUTCOME
Authors: Gautam Rakesh Kumar , Singh Manjeet , Bhattacherjee Dhritobroto , Kumar Juvesh , Singhal Shrey , Singh Chahal Jashandeep , Sagar Sagar
Published: March 2022

Introduction: Scaphoid fractures are among the most common injuries which are usually resulting from RTA, Accidental fall, Sports injury. The
greatest problems for the orthopaedic surgeon to treating the unstable scaphoid fracture and the complications (persistent pain at wrist, non-union,
hypertrophic scar) occur from Herbert screw xation that results in wrist strength. 25 patients were included in our study Material And Methods:
from OCTOBER 2019 to APRIL 2021, with subsequent period of follow up of 6 months (OCTOBER 2021). 25 patients with scaphoid fracture
treated by operative xation by Herbert screw. Regarding functional results, 24 case Results: s (96%) had no difculty doing day to day activity, in
last follow up according to Modied Mayo Wrist Score. Regarding post-operative complications, Scar tenderness (2 cases, 8%) was seen and
treated with local inltration of corticosteroids. One patient had developed cast failure and one patient had developed persistent pain. Conclusion:
We have concluded that fractures of scaphoid when xed with headless compression screw shows excellent functional outcome.
“A COMPARATIVE STUDY OF ESMOLOL AND DEXMEDETOMIDINE ON HAEMODYNAMIC RESPONSES TO CARBON DIOXIDE PNEUMOPERITONEUM DURING LAPAROSCOPIC SURGERY.”
Authors: Patel Chirag , Kothari Nikita , Khatri Kinjal , Parmar Yatin
Published: March 2022

Background: The advent of laparoscopic surgery has beneted the patient and surgeon, however creation of pneumoperitoneum for same has
bearings during the perioperative period. These effects of pneumoperitoneum are associated with signicant haemodynamic changes, increasing
the morbidity of the patient.
Aim: The present study compared the efcacy of dexmedetomidine and esmolol on hemodynamic responses to CO2 pneumoperitoneum during
laparoscopic surgery.
Material And Method: A total of 60 patients aged 20-50 y, American Society of Anaesthesiologists (ASA) physical status I or II, of either sex,
planned for laparoscopic surgery were included. The patients were randomly divided into two groups of 30 each. Group D received
dexmedetomidine bolus dose 1 mcg/kg IV in 100 ml NS and Group E received esmolol bolus dose 1 mg/kg IV in 10 ml of NS before creating
pneumoperitoneum.
Measurement: Heart rate (HR), systolic blood pressure, diastolic blood pressure and mean arterial pressure (MAP) were recorded preoperative,
vitals were recorded at intubation time, after intubation before creating pneumoperitoneum, after creating pneumoperitoneum, at 3,5,10 min and
then every 10 min intervals till 30 min after pneumoperitoneum. Propofol induction dose, intraoperative fentanyl requirement and rescue drug were
also recorded.
Result: In group D, there was no statistically signicant increase in HR and blood pressure after pneumoperitoneum at any time intervals, whereas
in Group E, there was a statistically signicant increase in MAP and HR after pneumoperitoneum at 10, 20, and 30 min. There was a signicant
decrease in induction dose of propofol and intraoperative fentanyl requirement in Group D and E.
Conclusion: Dexmedetomidine is more effective than esmolol for attenuating the hemodynamic response to pneumoperitoneum in elective
laparoscopic surgery. Dexmedetomidine and esmolol also reduced requirements of anaesthetic agents
TO ASSESS THE EFFECT OF VITAMIN D SUPPLEMENTATION IN THE PROGNOSIS OF CONGESTIVE HEART FAILURE PATIENTS BY 2D ECHOCARDIOGRAPHY IN NORTH INDIAN POPULATION
Authors: Kumar Randhir , Maurya Pavan , Chaturvedi Mridul , Chanana Sarthak
Published: March 2022

With growing epidemic of CAD there is a increase of patients of heart
failure in our country. Inspite of optimal use of ACE inhibitors, beta
blockers, statins (drugs which can alter the natural history of heart
failure) these patients have a gradually downhill course. Advanced
therapy like CRT and implantable debrillation therapy to reduce the
incidence of sudden cardiac death are very costly. Most of the Indian
poor patients can't afford such a costly therapy. Cheap intervention
which can alter the natural history of heart failure are strongly needed.
Most of the Indian patients have low vitamin D level. Low Vitamin D
level have been linked to increase risk of MI, Stroke, CVD mortality
and heart failure.
ASSOCIATION OF FAMILY CONFLICT AND FAMILY COHESION WITH DEVELOPMENT OF COMORBID DISRUPTIVE BEHAVIOR DISORDER IN CHILDREN WITH ATTENTION DEFICIT HYPERACTIVE DISORDER – A CASE CONTROL STUDY
Authors: Debnath Chandana , Kr Das Kaushik , Kr Patra Dipak
Published: March 2022

Objectives: Attention Decit Hyperactivity Disorder (ADHD) is one of the most common neuro-developmental disorders in children. Most
common comorbidity is Disruptive behavior disorder (DBD) consisting of Oppositional Deant Disorder (ODD) and Conduct Disorder (CD).
Family and social environmental factors may contribute to develop DBD in children with genetic vulnerability. This study was done to nd out the
association of family conict and family cohesion with development of comorbid DBD in children with ADHD. Methods: This case-control, cross
sectional study was done in a child Guidance clinic of R.G Kar Medical College, Kolkata. Total study population(N=154) comprises of children
diagnosed as ADHD with co morbid DBD (N=53), ADHD only (N=39) and Normal children (N=62). Children fullling the inclusion and
exclusion criteria were screened using Child symptom inventory (for10-12 years age) and Devereux Scales of Mental Disorders (for 13-15 years
age) and then diagnosed according to DSM IV TR. Control population was collected from schools after screening out for having any psychiatric
disorder (N =62). The consenting parents of the cases and control were assessed using Family Environmental scale (F.E.S). Results: Signicant
differences were found in family conict and family cohesion among these 3 groups. Families of children with ADHD with co morbid DBD (ODD
or CD) had signicantly higher family conict and lower cohesion than families of children with ADHD alone and control children. Conclusion:
High family conict and low cohesion are associated with development of DBD in children with ADHD.
“EFFECTIVENESS OF BALLISTIC EXERCISES AND STRENGTHENING EXERCISES TO REDUCE KNEE PAIN AND INCREASE LOWER LIMB STRENGTH IN YOUNG BADMINTON PLAYERS: A RANDOMIZED CONTROL TRIAL”
Authors: H Shah Digvi , Solanki Vidhya
Published: March 2022

Background: Badminton is one of the most active recreational sports played worldwide. The quick and repetitive movements while playing leads
to strenuous impact loading on the lower extremities. This further leads to knee pain, reduction in muscle strength.
Objective:To nd out the effectiveness of ballistic exercises and strengthening exercises to reduce knee pain and increase lower limb strength.
Methods: In a 6-weeks intervention study, 30 participants with knee pain were studied. The participants were divided into 3 groups Group A
(Ballistic Exercises), Group B (Strengthening Exercises), and Group C (Control Group) by lottery allotment method. A proper warm-up and cooldown regime was also given to the participants. Pre and post-treatment data were collected and analyzed using SPSS 22.0. Paired t-test and a oneway ANOVA test were used to nd out the signicance of the treatment.
Results: A signicant improvement in pain and muscle strength was found in Group A and B (p<0.05). Greater statistically signicant
improvement was seen in Group A as compared to B and C.
Conclusion: The study concluded that Ballistic Exercises are more effective as compared to Strengthening Exercises in order to reduce knee pain
and increase lower limb strength in young badminton players.
CIRCOM: A Robust and Scalable Language for Building Complex Zero-Knowledge Circuits
Authors: Muñoz-Tapia Jose L. , Belles Marta , Isabel Miguel , Rubio Albert , Baylina Jordi
Published: March 2022

A zero-knowledge (ZK) proof guarantees that the result of a computation is correct while keeping part of the computation details private. Some ZK proofs are tiny and can be verified in short time, which makes them one of the most promising technologies for solving two key aspects: the challenge of enabling privacy to public and transparent distributed ledgers and, enhancing the scalability limitations of distributed ledgers. Most practical ZK systems require the computation to be expressed as an arithmetic circuit that is encoded as a set of equations called rank-1 constraint system (R1CS).
In this paper, we present \circom, a programming language and a compiler for designing arithmetic circuits that are compiled to R1CS. More precisely, with \circom, programmers can design arithmetic circuits, and the compiler outputs (i) a file with the R1CS description, (ii) \wasm and \cpp programs to efficiently compute all values of the circuit. We also provide an open-source library called \circomlib, with multiple circuit templates. Moreover, \circom can be complemented with \snarkjs, a tool for generating and validating ZK proofs from R1CS. Altogether, our software tools abstract the complexity of the proving mechanisms and provide a friendly interface to model low-level descriptions of arithmetic circuits.
SVFL: Efficient Secure Aggregation and Verification for Cross-Silo Federated Learning
Authors: Luo Fucai
Published: March 2022

Cross-silo federated learning (FL) allows organizations to collaboratively train machine learning (ML) models by sending their local gradients to a server for aggregation, without having to disclose their data. This paper proposes SVFL, an efficient protocol for cross-silo FL, that supports both secure gradient aggregation and verification. We evaluate the performance of SVFL and show, by complexity analysis and experimental evaluations, that its computation and communication overhead remain low even on large datasets, with a negligible accuracy loss (less than $1\%$). Furthermore, we conduct an experimental comparison between SVFL and other existing FL protocols, and show that SVFL achieves significant efficiency improvements in both computation and communication.
Efficient Propagation Modeling for Communication Channels with Reconfigurable Intelligent Surfaces
Authors: Liu Yuanzhi , Sarris Costas
Published: March 2022

We present a hybrid numerical method that combines full-wave analysis with ray-tracing to efficiently model propagation in reconfigurable intelligent surface (RIS)-enabled communication channels. Full-wave simulation is used to obtain the radiation pattern of the transmitter and the complex radar cross-section (RCS) of the RIS. Then, the RIS is imported into a ray-tracer as a secondary transmitter. That enables the modeling of the interaction of the RIS with complex environments. We present the formulation of the proposed technique and its validation against full-wave (finite element) results in representative scenarios of indoor propagation in the presence of an RIS.
Third-Party Institutional Proxy Advisors: Conflicts of Interest and Roads to Reform
Authors: Fagan Matthew
Published: March 2022

With the rise of institutional activist investors in recent decades—including a purported 495 activist campaigns against U.S. corporations in 2016 alone—the role that third-party institutional proxy advisors play in corporate governance has greatly increased. The United States Office of Government Accountability estimates that clients of the top five proxy advisory firms account for about $41.5 trillion in equity throughout the world. For several years, discussions have developed regarding conflicts of interest faced by proxy advisors. For example, Institutional Shareholder Services, the top proxy advisory firm in the world, frequently provides advice to institutional investors on how to vote proxies while simultaneously providing corporate clients with advice on how to improve their corporate governance. Situations like these have given rise to debate as to whether such conflicts are truly problematic.

At a minimum, institutional investors must be confident in the services that are provided to them by proxy advisors. Without a showing that recommendations are given in a neutral and non-biased way, accidentally or intentionally, the system cannot work effectively to maximize shareholder fairness.

This Note posits that, despite the fact that third-party proxy advisors are currently acting within the law, reforms should be made that better address and limit the amount of conflicts of interest that may arise as a result of their business. Such reform should take place through legislation, informal SEC notice and comment, or, potentially, through the voluntary action of proxy advisory firms.
Скорочення трудомісткості виготовлення обробки отворів складної форми із застосуванням керованої розточувальної системи
Authors: Aleksiienko H.
Published: March 2022

У статті розкрито принципи скорочення трудомісткості виготовлення обробки отворів складної форми із застосуванням керованої розточувальної системи. Визначено етапи еволюції сучасної металообробної техніки. Охарактеризована будова розточувальної головки та визначено її місце у загальні металообробній системі на базі верстата з числовим програмним управлінням. Підкреслено, що на сьогодні, з розвитком автоматизації виробництва, більшою мірою використовують автоматичні розточувальні головки, які мають автоматичну радіальну подачу, що робить їх більш універсальними як при обробці отворів, так і при обробці зовнішніх поверхонь, такі головки мають великий діапазон обробки. Визначено характеристики автоматичної розточувальної головки та наголошено на перевагах застосування. Так використання автоматичних розточувальних головок дозволяє значно скоротити час обробки, збільшити точність і підвищити якість поверхні, що обробляється. Враховуючи, що розточувальні головки за своєю суттю, є приладдям яке знімається, спектр їх застосувань доволі широкий від координатно-розточувальних верстатів до агрегатних верстатів на базі обробних центрів. Представлено структурну схему управління верстатом з ЧПУ з відокремленням основних блоків, що входять до її складу та умовно розкрито схему реалізації керування обертами розточувальної головки. Наголошено, що впровадження мікропроцесорної системи управління позиціонуванням різця в розточувальній головці дозволить збільшити можливості формоутворення, а саме виконувати фасонні, циліндричні, ступінчасті та конусні отвори за один підхід, що дозволить скоротити час обробки, і найголовніше керувати точністю одержуваної продукції, а також скоротити номенклатуру використовуваного інструменту. Сформовано математично модель управління розточувальної головки та описано основні фактори впливу. Підкреслено, що технологічний процес характеризується силою різання та положенням розточувальної головки і може бути представлений у вигляді траєкторії руху її розточувальної кромки. Наголошено, що така система управління здійснює реалізацію процесу розточування отворів за рахунок формування траєкторії та порівняння її з еталонною траєкторією. Здійснення передачі даних блоком зворотного зв’язку запропоновано на технології Bluetooth, яка в умовах сьогодення є бюджетною та максимально дієвою у рамках заявлених вимог.
Mitybos savitumai nėštumo laikotarpiu
Authors: Petereit Rūta
Published: March 2022

Nėštumas – tai gyvenimo periodas, kai užsimezgusios gyvybės egzistavimą nuo pirmųjų dienų sąlygoja daug veiksnių. Tai ypatinga moters dvasinė būsena, kuri mobilizuoja kūrybines jėgas, skatina saugoti sveikatą, tinkamai maitintis. Nuo nėščiosios mitybos nemaža dalimi priklauso pieno gamyba ir jo maistinė vertė, gimsiančio naujagimio fizinė būklė bei pačios moters sveikata.
Revision of the family Metarbelidae (Lepidoptera) of the Oriental Region. VIII. Genus Lutzkobesia Lehmann, 2019
Authors: Yakovlev Roman V. , De Vos Rob , Hulsbosch Ramon , Zolotuhin Vadim V.
Published: March 2022

In the eighth part of the revision on the Asian Metarbelidae (Lepidoptera) we consider the genus Lutzkobesia Lehmann, 2019, which includes two species, distributed in Western Indonesia (the islands of Sumatra and Java): L. hollowayi Lehmann, 2019 and L. tenera (Roepke, 1957) comb. n.
Plasma Calcium and Phosphorus Levels and Cardiovascular Disease Risks in Egyptian Type 2 Diabetic Patients
Authors: Al-Okbi Sahar , Sabry Seham , Al-Siedy Enas S. K. , Elsayed Shaimaa
Published: March 2022

Background: Cardiovascular complication of diabetes is considered an important issue that needs deep investigations. The levels of plasma calcium (Ca) and phosphorus (P) have been implicated as having an association to cardiovascular diseases.
AIM: The objective of the present research was to study the plasma levels of both Ca and P and their association to the atherogenic ratio; total cholesterol: high density lipoprotein-cholesterol and the plasma albumin in male and female patients with type 2-diabetes. The interrelation between anthropometric parameters represented by body mass index (BMI), waist circumference and waist/hip ratio with Ca and P were studied. Also, the association between plasma Ca and P with their dietary intake were investigated.
Subjects and METODS: Thirty-one type 2-diabetic male and female patients participated in the study, in addition of ten healthy subjects. Biochemical parameters, anthropometric measurements and nutrients′ intake were assessed. Biochemical parameters include plasma Ca, P, lipid profile, albumin, liver function tests and creatinine.
RESULTS: Plasma Ca levels of female patients of BMI> 30 kg/m2 demonstrated significant increase compared to the control group.  All male and female patients showed significant increase in plasma P compared to the control group. Glycosylated hemoglobin of male and females showed significant high values compared to the control group except for diabetic male of BMI>30 kg/m2 that showed insignificant increase. No significant changes in plasma TG and LDL-C levels were noticed compared to the control.  Plasma TC of patients showed significant high levels compared to the control group. The levels of HDL-C of patients were significantly lower than that of the control. The ratios of TC/HDL-C diabetic patients either male or female and whatever their BMI were significantly higher than that of the control. No significant changes in plasma activities of ALT and AST and bilirubin levels were observed among the different groups including the control.  Plasma albumin levels demonstrated significant reduction compared to the control group whatever their sexes or BMI. Plasma creatinine levels of the different diabetic groups showed insignificant change from the control group except for the male group of BMI<30 kg/m2 that showed significant elevation. In male, plasma Ca showed significant negative correlation with albumin and positive correlation with creatinine and dietary vitamin D. In female, a significant positive correlation was noticed between plasma and dietary P while a negative correlation was observed between plasma Ca and dietary iron.
CONCLUSION: Elevated of plasma P together with reduced plasma albumin and elevated TC/HDL-C may reflect an association of plasma P to CVD in male and female diabetic subjects while high plasma Ca might predict CVD in only female diabetic patients of BMI > 30 kg/m2.
Malnutrition as Risk Factor for Febrile Neutropenia in Children with Acute Lymphoblastic Leukemia
Authors: Hanzelina Hanzelina , Widnyana A. A. N. K. P. , Windiani I Gusti Ayu Trisna , Karyana I Putu Gede , Ariawati Ni Ketut , Mahalini Dewi Sutriani
Published: March 2022

BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Febrile neutropenia is one of medical emergencies in ALL patients. One of the risk factors that associate with febrile neutropenia is malnutrition. Malnutrition reduce the body’s immunity that increase incidence of infection.
AIM: aimed to prove malnutrition as risk factor in children with ALL who had febrile neutropenia
METHOD: This is case-control study with samples a hundred children aged 1 month to 18 years old with ALL at Sanglah Hospital Denpasar between 2015 - 2021. Subjects were grouped into two, those with febrile neutropenia and without febrile neutropenia.  The relationship between malnutrition and febrile neutropenia was analyzed by using chi-square bivariate analysis test.
 
RESULTS: A hundred subjects were devided into two groups with 50 subjects each group. Bivariate analysis showed significant association between malnutrition and febrile neutropenia (OR 4.53; 95%CI 1.95 - 10.51; p-value <0.001).
CONCLUSION: Malnutrition as risk factor for febrile neutropenia in children with ALL.
Effect of Vitamin D Supplementation on Insulin Resistance Status in Pubertal Girls with Congenital Adrenal Hyperplasia
Authors: Abdou Marise , Hassan Mona Mamdouh , ElAtti Sahar Abd , Aiad Diana Nabil , Ibrahim Amany
Published: March 2022

Introduction: Congenital adrenal hyperplasia (CAH) patients especially females are at increased risk for developing obesity and resistance to insulin (IR). Rising evidence indicate that insufficient vitamin D levels are associated with impaired function of β-cells of islets of Langerhans and IR, however, this finding hasn’t been investigated in patients with CAH. The aim was to identify the vitamin D levels and insulin resistance status in pubertal females with CAH, following up at Diabetes Endocrine and Metabolism Pediatric Unit, Abou ElRish Children’s Hospital, Cairo University. We also examined the association between vitamin D level & insulin resistance and the impact of cholecalciferol administration on metabolic abnormalities.
Subjects and Methods: Sixteen pubertal CAH females with deficient or insufficient Vitamin D levels were recruited. Follow up was done after a period of 6 months during which oral Vitamin D replacement therapy was prescribed.
Results: The serum levels of 25-hydroxyvitamin D (25(OH)D3) were significantly raised following replacement therapy. Significant correlation was detected between HOMA-IR and serum levels of insulin, other IR indices both prior to and following vitamin D supplementation. However, HOMA-IR didn’t correlate with any of the following: 25(OH)D3 levels, 17 hydroxyprogesterone (17-OHP), or steroid dose either prior to or following replacement therapy.
Conclusion: Vitamin D replacement therapy didn’t have favorable effects on IR in females with CAH. Future research using randomized controlled trials is required to examine the impact of Vitamin D on IR. This might influence the production of adrenal androgen, resulting in reduction of the therapeutic effect of glucocorticoids and evolution of metabolic derangements.
Design of the integrated AFS and DYC scheme for vehicles via FTSM and SOSM techniques
Authors: Zhang Lina , Ma Li , Chen Shan
Published: March 2022

Improving the stability and safety is of great significance for the in-wheel electric vehicle. There are many studies only concentrating on active front steering (AFS) control or direct yaw-moment control (DYC). However, When the in-wheel electric vehicle is under extreme conditions, AFS or DYC alone is not effective. In this paper, an integrated controller of AFS and DYC is proposed. Firstly, the ideal values of yaw rate and sideslip angle can be calculated based on the two-degree-of-freedom vehicle model. Secondly, the AFS controller is obtained according to the backstepping-based fast terminal sliding mode (FTSM). Then, the DYC controller which consists of the upper controller and the lower controller is constructed. The upper controller is developed via the integral-based second-order sliding mode (SOSM). The appropriate torque is outputted to each wheel by the lower controller. Finally, the simulation results show that the actual yaw rate and sideslip angle can approach the ideal ones as closely as possible under the proposed integrated controller.
Investigation on chemical composition, antioxidant activity and SARS-CoV-2 nucleocapsid protein of endemic Ferula longipedunculata Peşmen
Authors: Göçeri A. , Demirtaş İ. , Alma M.H. , Adem Ş. , Kasra Z.A. , Gül F. , Uzun A.
Published: March 2022

The essential and fatty oils were investigated and a quantitative analysis of the root, green and stem parts of F. Longipedunculata was performed by GC-MS and HPLC-TOF/MS and their antioxidant (DPPH method) activities and potential binding of phytochemicals against SARS-CoV-2 nucleocapsid were determined using Molegro Virtual Docker software. In the root part of the plant, the prominent components of oil were β-phellandrene (53.46%), ocimene (6.79%), 4-terpineol (5.94%) and santalol (5.03%). According to the quantitative results, vanillic acid (141.35 mg/kg), ferulic acid (126.19 mg/kg) and 4-hydroxybenzoic acid (119.92 mg/kg) were found in the roots; quercetin-3-β-O-glycoside (1737.70 mg/kg), quercetin (531.35 mg/kg) and ferulic acid (246.22 mg/kg) were found in the in the green part; and fumaric acid (2100.21 mg/kg), quercetin-3-β-O-glycoside (163.24 mg/kg), vanillic acid (57.59 mg/kg) were detected in the stem part. The antioxidant activity of all parts of the plant was higher than the control with BHT. Silibinin, rutin, and neohesperidin exhibited a stronger affinity than nucleotides. In the silico analysis, many of the phytochemicals were attached with strong hydrogen-bonds and electrostatic effects to the amino acids to which nucleotides are bound. The results indicated that the plant showed antioxidant effects and can be effective against SARS-CoV-2 thanks to the different phytochemical compounds it contains.
Limites e possibilidades de agentes comunitários de saúde na identificação de sintomas depressivos/Limitations and possibilities of community health workers in identifying depressive symptoms
Authors: Brito Rodrigues Ana Paula , Carvalho e Silva Sales Jaqueline , Silva Júnior Fernando José Guedes da , Silva de Moura Marcoeli , Ferreira de Souza Monteiro Claudete , Cardoso Costa Ana Paula , Tereza de Galiza Francisca
Published: March 2022

Objetivo: avaliar o conhecimento de agentes comunitários de saúde sobre identificação de sintomas depressivos na comunidade. Método: trata-se de pesquisa qualitativa, realizada em Unidade Básica de Saúde, em Teresina, Piauí, Brasil, com 15 agentes comunitários de saúde. Utilizou-se o método da Pesquisa-Ação. A produção dos dados aconteceu em janeiro e fevereiro de 2019, por meio de dois seminários temáticos, pautados no Método Criativo Sensível.  Os discursos foram submetidos à análise temática. Resultados: agentes comunitários de saúde reconhecem os sintomas depressivos por tristeza, choro, isolamento, anedonia e solidão, manifestados pelos indivíduos. Os limites para essa identificação, relatados pelos profissionais, foram dificuldade de acesso aos usuários e às famílias e estigma e preconceito com a depressão. Quanto às possibilidades, destacaram-se acesso à informação sobre a temática pela mídia, diálogo/conversa estabelecido entre usuário e profissional e acesso à rede de apoio. Considerações finais: conclui-se que o reconhecimento, as limitações e as possibilidades de identificação de sintomas depressivos por esses profissionais refletem no diagnóstico, planejamento e implementação de ações no cuidado em saúde mental de forma precoce e segura.
Fatores associados à autoeficácia e à adesão da terapia antirretroviral em pessoas com HIV: teoria social cognitiva/ Factors associated with self-efficacy and adherence to antiretroviral therapy in people with hiv: cognitive social theory
Authors: Da Rocha Cabral Juliana , Da Rocha Cabral Luciana , Chianca de Andrade Moraes Danielle , Cassia da Silva Oliveira Elizandra , De Aquino Freire Daniela , Pereira da Silva Felicialle , Célia de Oliveira Regina
Published: March 2022

Objetivo: analisar a adesão à terapia antirretroviral e a expectativa de autoeficácia em pessoas vivendo com o vírus da imunodeficiência humana (HIV) à luz da teoria social cognitiva. Métodos: estudo transversal, descritivo, epidemiológico e quantitativo com pessoas vivendo com o HIV. Dados foram coletados de abril a setembro de 2018, através do “Cuestionario para la Evaluación de la Adhesión al Tratamiento Antirretroviral” (CEAT-VIH) e a escala de expectativa de autoeficácia, validada e desenvolvida no Brasil, onde foi utilizado o teste Mann-Whitney. Foi aplicado o modelo de Poisson para avaliação da probabilidade de boa adesão ao instrumento CEAT-VIH. Resultados: identificou-se a média de idade de 44 anos, predomínio de homens. A adesão regular apresentou maior representatividade. A maior mediana da adesão encontrada foi para as questões relacionadas à experiência, efeitos e sentimentos negativos. No ajuste do modelo de Poisson, segundo o instrumento CEAT-VIH, verifica-se que apenas a escolaridade e a categoria relativa à atenção, à organização e ao planejamento para tomada da terapia antirretroviral (TARV) são fatores conjuntamente determinantes para boa adesão. Conclusão: observou-se a não adesão satisfatória ao tratamento medicamentoso, fato que se deve a fatores inerentes à TARV, como vulnerabilidade social, estigma e as relações de expectativa de autoeficácia, comprometendo a manutenção da sobrevida com maior morbidade e interferindo na qualidade de vida.
Perfil dos atendimentos pré-hospitalares em serviço de atendimento móvel de urgência no nordeste do brasil/Profile of pre-hospital care in a mobile emergency care service in northeast brazil
Authors: Batista de Carvalho Silva João , Batista de Oliveira Lairton , Karielle Coelho Macedo Fernanda , De Sousa Moura Levi David , Sylca de Jesus Sousa Antônia , De Sousa Nobre Roseanne , Gilberto Fernandes Pereira Francisco
Published: March 2022

Objetivo: Descrever o perfil epidemiológico dos atendimentos pré-hospitalares realizados por um serviço móvel de emergência no município de Picos, Piauí, Brasil. Métodos: Trata-se de um estudo transversal, documental e retrospectivo com abordagem quantitativa, realizado nos meses de abril e maio de 2020. Foram analisados 4.220 registros com base nos atendimentos realizados pelo Serviço de Atendimento Móvel de Urgência às ocorrências que aconteceram no período de janeiro de 2019 a março de 2020. Os dados foram coletados das fichas de atendimento individuais da instituição, organizados por meio de um formulário e analisados à luz da estatística descritiva. Resultados: Foi observada frequência de ocorrências ligeiramente maior em indivíduos do sexo masculino (50,3%), predominância das faixas etárias de 20 a 30 anos (30,7%) e maior de 60 anos (34,2%), atendimentos realizados pela Unidade de Suporte Básico (65,9%). As ocorrências traumáticas provenientes de acidentes de transporte (68,5%) e as clínicas cardiológicas (18%) se apresentaram em maior percentual em relação às demais. As ocorrências traumáticas foram mais frequentes no período de outubro a dezembro e as clínicas nos meses de fevereiro e março. Conclusão: O perfil epidemiológico dos atendimentos corresponde à população do gênero masculino e faixa etária maior ou igual a 60 anos. Predominaram as ocorrências de natureza clínica, principalmente cardiológicas.
Perfil de gestantes institucionalizadas da região noroeste do Paraná / Profile of institutionalized pregnant women in the northwest region of Paraná
Authors: Tonon Martina Mesquita , Oliveira Magda Lúcia Félix de , Dematte Luciana Pizolio Garcia , Monteiro Leticia Rafaelle de Souza , Jaques André Estevam , Tonin Paula Teresinha
Published: March 2022

Objetivo: Analisar o perfil sociodemográfico de gestantes em situação de risco. Métodos: Trata-se de um estudo retrospectivo, do tipo documental, com caráter quantitativo, realizado em uma instituição não governamental na região noroeste do Paraná. Foram analisados prontuários correspondentes aos anos de 2016 a 2019, totalizando 180 prontuários. Os dados foram compilados e processados por meio de estatística descritiva simples. Resultados: Foram analisados 180 prontuários, desses, constatou-se que a idade mínima das gestantes institucionalizadas estava entre 12 anos e 40 anos de idade, com a faixa etária predominante entre 21 e 30 anos. Dentre essas, 91 gestantes (50,54%) se autodeclaravam pardas ou pretas. Quanto ao grau de escolaridade, 107 (59,44%) possuíam ensino médio incompleto, e 95 (52,78%) já haviam tido uma gestação anterior. Dentre os principais motivos pelos quais as gestantes se encontravam em situação de vulnerabilidade, estavam os transtornos mentais, a violência doméstica e os conflitos familiares. Conclusão: Estudos que avaliem o perfil sociodemográfico das gestantes em situação de vulnerabilidade social são importantes para que profissionais de enfermagem possam reconhecer e elaborar estratégias para minimizar riscos para a saúde materno-infantil, estabelecer maior vínculo e assisti-las de forma integral por meio do pré-natal.
MAPEAMENTO TÉRMICO NA ANÁLISE DAS CONDIÇÕES DE CONFORTO EM EDIFICAÇÕES
Authors: Kowalski Luiz Fernando , Monteiro da Rocha Odiléia Karina , Akmitsu Afuso Lucas , Gatica Ríspoli Ítalo Alberto Gatica Ríspoli
Published: March 2022

O desempenho térmico da edificação está diretamente associado às condições de conforto do usuário. Escolher materiais adequados juntamente com o monitoramento térmico de um ambiente são fatores que auxiliam no conforto, melhorando as condições de uso do espaço. Este trabalho tem como objetivo analisar a temperatura do ar interna em um edifício de uso laboratorial. Para aquisição de dados foram distribuídos sensores de temperatura em 10 pontos estratégicos no edifício. A partir dos resultados obtidos, nota-se pontos críticos de temperatura, influenciados pela geometria de insolação, isolamento térmico da cobertura e das paredes, ventilação e vegetação em seu entorno. Os resultados obtidos serviram como auxílio na produção de mapas térmicos do ambiente, possibilitando a identificação da temperatura do ar em toda a edificação em diferentes cenários. Através desses mapas foi possível avaliar as condições do conforto térmico da área de estudo, se mostrando uma ferramenta eficiente.
INFLUÊNCIA ESTRUTURAL DE PAVIMENTO RODOVIÁRIO PÓS-RECONSTRUÇÃO
Authors: Marques Almeida Antonia Fabiana , Cavalcante de Almeida Lucas , Lacerda de Oliveira Francisco Heber
Published: March 2022

O levantamento estrutural de uma rodovia avalia a capacidade de carga do pavimento e, a partir dos seus resultados, podem ser indicadas as medidas de manutenção ou reabilitação para garantia da sua vida útil. Esses levantamentos também podem ser utilizados para estimar, por meio de retroanálises, parâmetros dos materiais constituintes das camadas do pavimento. Nesse sentido, este trabalho tem como objetivo analisar os dados oriundos de levantamento deflectométrico de um trecho de rodovia em pavimentação flexível para verificar a eficácia da sua reconstrução e as informações de módulo de resiliência obtidas por retroanálises. Os resultados mostraram que, de maneira global, a reconstrução foi adequada para a capacidade estrutural da rodovia, com exceção de alguns segmentos, e que a análise deflectométrica e a retroanálise podem ser alternativas viáveis se comparadas aos ensaios destrutivos.
Review of the “Sisu Seriya” School Bus Service
Authors: Kumarage A. S. , Kandanaarachchi T. , Karunarathne A.
Published: March 2022

School Transport is considered an essential service that provides equitable access to school children who have difficulties in accessing their respective schools. Different school transport systems in countries differ from each other based on their resources and topography. This paper presents a case study conducted on the Sri Lankan School Bus service “Sisu Seriya" initiated in 2005 to provide a sustainable, reliable and safe mechanism for providing State assistance for school transport. It provides bus service at a concessionary rate through a state subsidy to schoolchildren across the country, contracting bus operators in both public and private sectors, engaged for regularly scheduled services through a specific contractual arrangement in which a set of regulatory and safety conditions are stipulated. Sisu Seriya engages over 1,565 buses serving more than 100,000 school children daily. This paper has benchmarked the Sisu Seriya service through a systematic review of global best practices. Initiation of the system, design features, implementation mechanism and monitoring procedures of the Sisu Seriya service and areas for potential improvement are discussed based on its 15 years of operation, while elucidating the distinctive characteristics of the system. It further highlights how the service design has addressed the challenge of resource limitations, inherent to developing countries, through effective utilization of the existing fleet.
Study on the Candida in-patient with Pulmonary Tuberculosis
Authors: Song Sun Bo , Paik Nak Hyung
Published: March 2022

Candida was studied in the sputum of 173 cases of normal persons, and 180 cases of Pulmonary tuberculosis, by the culture method with Sabourand glucose agar containing penicillin and atreptomycin. Canbiba species were classified by the method of “Marten et al".Positive rates of candida species were 20.0% in Pulmonary tuberculosis and 8.7 % in normal persons, Positive rate of Candida albicans was 72.2% in Candida-positive tuberculosis patients and 73.3% in Candida-positive normal persons. In Pulmonary tuberculosis patients, Candida positive rate was 13.8% in the serous-sputum, and Candida positive rate was increased in proportion to the increase of the sputum.There was no significant relationship between the extent of lung parenchymal Iesions and/or the Gaffky numbers with Candida positive rates. ln patients treated by the antituberculosis drugs, but not having used Isoniazid 16.7% were Candida positive cases. This indicates were a lower rate in the group not havins used of P. A. S. and S. M. and in the duration of their treatment, there was nothing significant in the Candida positive rates. In the cavitarious patients, the Candida positive rate was 30. 4%, which is high. The size of the cavity did not effect the positive rates of the Candida species. It was also noticed that there was no relationship between the Candida positive rate and the erythrocyte sedimentation rate. Positive rates changed with clinical symptoms, 27.3% of cases with cough, 24. 0% of cases with anorexia, 24. 1 % of cases with body weight loss, 25. 0% of cases with dyspnea, so that, these are slightly higher rates than average, but the 15.4% of cases with chest pain is slightly Iower. Vertigo ancl night sweating are not significant t o positive rates. Ap pendix: Candida albicans, which was found most frequently, was characterized by the formation of Terminal chlamydospore in the com meaI agar.ln the past, it was complicated and required a long time to find chlamydospore. But, through much experience, we discovered a simplified method for chlamydospore and report it here.Germs cultured purely at Sabouraud glucose agar slant, are collected with a platinum wire loop. The surface of agar reantiostabbed along the wall of tube to the base" and placed in a beaker filled with water. It is then culturd for one to two days at room temperature, (20℃)We observe lineal growth along the stabbed line. There-after, a small amount of culture is taken and placed on the slide, covered with cover glass, pressed, and examined by microscope directly and by staining.For staining, we used Pfeiffer's solution and Gram’ s reagents.
Research on pulmonary tuberculosis chemotherapy
Authors: Kim Kyung sik
Published: March 2022

No abstract available
The Audiometric Studies on Chronic Pulmonary Tuberculosis Patients Treated with Streptomycin
Authors: Chang Kwang Sub , Choi Heung Jai , Kim Kiho , Kim Hyun Soo , Yoon Sang Ha
Published: March 2022

1) The audiometric studies of 103 case Selected from the Chronic pulmonary tuberculosis patients in Soon Wha Hospital were done.2) This study revealed that the hearing impairment is increased in its occurrence and severity along with the increasing amount of Streptomycin administered, and this tendency is more evident in the frequencies other than conversational area.3) In the detection of hearing impairment in Streptomycin toxity, the routine audiometric study is the primal importance rather than it's emergence of subjective symptoms.
An Evaluation of Streptomycin in the Pulmonary Tuberculosis Therapy Trials
Authors: Song Sun Bo , Kang Suck Yung , Kim Kyung Sik
Published: March 2022

Streptomycin and dihydrostreptomycin, causing estibular damage and hearing disturbance or deafness, have given us puzzles to use so frequently is desired by clinicians, so that those were recommended to use carefully 2-3 times weekly. However, according to recent report, the daily use of streptomycin accompanied with other antituberculosis drugs is considered to be far more effective than any other regimens of tuberculosis therapy.Therefore, we observed the four regimens of tuberculosis therapy for four months, which had no previous experiences of tuberculosis chemotherapy. The regimens were PAS-isoniazid, isoniazid-SM-(bi-or tri-weekly). PAS-isoniazid-SM(bi- or triweekly), and PAS-isoniazid-SM(daily, which was interrupted at 3 months after commencement of chemotherapy.)The results obtained were mainly concentrated on to clinical and roentgenographic improvement.reversal of infectiousness. erythrocyte sedimentation rate. change of εody weight, increasing of the numbers of lymphocytes and cavitary change . Of most effective regimen among four groups. we have learned that PAS-isoniazid-SM daily has brought us the impression of excellency in tuberculosis treatment. On the patients in which toxicity of SM appeared, there were three cases(3.8 percent) of hearing disturbance and six cases(7.7 percent) of tinnitus out of 78 cases. Thus, the fourth regimen may be considered to be of efficient regimen in tuberculosis therapy, if it is carried out under the careful observation and supervision.