bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Music Intervention on Pallidum‐DMN Circuit of Schizophrenia
Authors: Yao Yutong , He Hui , Duan Mingjun , Li Shicai , Li Cheng , Chen Xi , Yao Gang , Chang Xin , Shu Haifeng , Wang Hongming , Luo Cheng
Published: September 2020

Music intervention has been applied to improve symptoms of schizophrenic subjects as a complementary treatment in medicine. Although the psychiatric symptoms, especially for motivation and emotion, could be increased in schizophrenia, the underlying neural mechanisms remain poorly understood. We employed a longitudinal study to measure the alteration of striatum functional networks in schizophrenic subjects undergoing Mozart music listening using resting‐state functional magnetic resonance imaging (fMRI). Forty‐five schizophrenic inpatients were recruited and randomly assigned to two groups. Under the standard care with antipsychotic medication, one group received music intervention for 1 month and the other group is set as control. Both schizophrenic groups were compared to healthy subjects. Resting‐state fMRI was acquired from schizophrenic subjects at baseline and after one‐month music intervention and from healthy subjects at baseline. Striatum network was assessed through seed‐based static and dynamic functional connectivity (FC) analyses. After music intervention, increased static FC was observed between pallidum and ventral hippocampus in schizophrenic subjects. Increased dynamic FCs were also found between pallidus and subregions of default mode network (DMN), including cerebellum crus and posterior cingulate cortex. Moreover, static pallidus‐hippocampus FC increment was positively correlated with the improvement of negative symptoms in schizophrenic subjects. Together, these findings provided evidence that music intervention might have an effect on the FC of the striatum‐DMN circuit and might be related to the remission of symptoms of schizophrenia.
Identification of Six Flavonoids as Novel Cellular Antioxidants and Their Structure-Activity Relationship
Authors: Zhang Qiang , Yang Wenbo , Liu Jiechao , Liu Hui , Lv Zhenzhen , Zhang Chunling , Chen Dalei , Jiao Zhonggao
Published: September 2020

This study is aimed at determining the relationship of flavonoid structures to their chemical and intracellular antioxidant activities. The antioxidant activities of 60 flavonoids were investigated by three different antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, oxygen radical absorption capacity (ORAC), and cellular antioxidant activity (CAA) assays. The result showed 6 flavonoids as good cellular antioxidants evaluated for the first time. The cellular antioxidant activities of compounds 7-methoxy-quercetin, 3-O-methylquercetin, 8-hydroxy-kaempferol, quercetin-3-O-α-arabinofuranose, kaempferol-7-O-glucopyranoside, and luteolin6-C-glucoside were linked with the upregulation of antioxidant enzyme activities (superoxide dismutase, catalase, and glutathione peroxidase). A structure-activity relationship suggested that 2,3-double bond, 4-keto groups, 3′,4′-catechol structure, and 3-hydroxyl in the flavonoid skeleton played important roles in the antioxidant behavior. Furthermore, the cell proliferative assay revealed a low cytotoxicity for 3-O-methylquercetin. The present results provide valuable information for the dietary application of flavonoids with different structures for high antioxidant.
Human Detection through RSSI Processing with Packet Dropout in Wireless Sensor Network
Authors: Wang Haijing , Zhang Fangfang , Zhang Wenli
Published: September 2020

This paper presents a device-free human detection method for using Received Signal Strength Indicator (RSSI) measurement of Wireless Sensor Network (WSN) with packet dropout based on ZigBee. Packet loss is observed to be a familiar phenomenon with transmissions of WSNs. The packet reception rate (PRR) based on a large number of data packets cannot reflect the real-time link quality accurately. So this paper firstly raises a real-time RSSI link quality evaluation method based on the exponential smoothing method. Then, a device-free human detection method is proposed. Compared to conventional solutions which utilize a complex set of sensors for detection, the proposed approach achieves the same only by RSSI volatility. The intermittent Karman algorithm is used to filter RSSI fluctuation caused by environment and other factors in data packets loss situation, and online learning is adopted to set algorithm parameters considering environmental changes. The experimental measurements are conducted in laboratory. A high-quality network based on ZigBee is obtained, and then, RSSI can be calculated from the receive sensor modules. Experimental results show the uncertainty of RSSI change at the moment of human through the network area and confirm the validity of the detection method.
Nonparametric Range-Based Double Smoothing Spot Volatility Estimation for Diffusion Models
Authors: Cai Jingwei
Published: September 2020

We consider nonparametric spot volatility estimation for diffusion models with discrete high frequency observations. Our estimator is carried out in two steps. First, using the local average of the range-based variance, we propose a crude estimator of the spot volatility. Second, we use usual nonparametric kernel smoothing to reconstruct the volatility function from the crude estimator. By inference, we find such a double smoothing operation can effectively reduce the estimation error.
Educational Intervention Improved Parental Knowledge, Attitudes, and Practices (KAP) and Adherence of Patients with Celiac Disease to Gluten-Free Diet
Authors: Elsahoryi Nour Amin , Altamimi Eyad , Subih Hadil Shafee , Hammad Fwziah Jammal , Woodside Jayne V.
Published: September 2020

Background. Raising the knowledge level though education for a celiac disease patient’s parents could improve the parent’s adherence and practice and consequently recover the patient’s adherence and symptoms and increase the patient’s compliance. Aim. The present study was aimed at assessing the knowledge, attitudes, and practices (KAP) of parents who have children with celiac disease aged from 2 to 15 years old and the change in self-reported patient’s adherence pre-/posteducational intervention. Method. This intervention study was designed as a quasiexperiment with evaluation pre-/post intervention analyses. Two educational sessions were carried for the parents of CD patients. A reliable and valid questionnaire was used to assess all independent variables pre-/post intervention. The parents were asked to complete the questionnaire pre and post the education sessions. The time between the sessions was two weeks. Results. 100 parents were recruited, and 40 parents participated and completed the study. Baseline parent’s knowledge was significantly associated with the source of information (p value = 0.02), while the patient’s adherence was associated with the onset of disease (p value = 0.04). There were significant differences in the parent’s KAP and patient’s adherence between pre- and posteducational intervention (p value was ≤0.001, for all variables). Conclusion. Based on the results, this study suggested that the educational intervention increased the parent’s KAP and improved the patient’s adherence to the gluten-free diet significantly, which may lead to improvement in the celiac disease patients’ health outcomes.
Fish Bone Causing Perforation of the Intestine and Meckel’s Diverticulum
Authors: Shahid Fakhar , Abdalla Samir Omer , Elbakary Tamer , Elfaki Ahmad , Ali Syed Muhammad
Published: September 2020

Perforation of small bowel due to ingested fish bone is rare, the most common site is ileum and occasionally, it can involve the appendix and/or Meckel diverticulum. We report six patients who, developed bowel perforation after fish bone ingestion, four of them found to have rent in the ileum and two through Meckel’s diverticulum and presented with abdominal pain and localized peritonitis. All underwent surgical exploration and removal of the fish bone and closure of the small intestine/excision of the diverticulum. Foreign body ingestion should be kept in mind in suspicious cases, and laparoscopy is very important to diagnose such rare cases as they may commonly be missed by imaging.
Equipping the American Joint Committee on Cancer Staging for Resectable Pancreatic Ductal Adenocarcinoma with Tumor Grade: A Novel Staging System
Authors: Ren Hu , Wu Chao-Rui , Qiu Guo-Tong , Zhang Li-Peng , Aimaiti Saderbieke , Wang Cheng-Feng
Published: September 2020

Background. The 8th American Joint Committee on Cancer (AJCC) staging system for pancreatic ductal adenocarcinoma (PDAC) outperforms its previous version in reproducibility but not in survival discrimination. Tumor grade, an indicator of the aggressive biology of PDAC, has been suggested as a reliable prognostic factor. This study aimed to construct a novel staging system with greater prognostication for resectable PDAC by incorporating tumor grade into the 8th AJCC system. Methods. A total of 9966 patients with resectable PDAC from the Surveillance Epidemiology and End Results (SEER) database were randomly separated into training and interval validation sets. Another 324 patients from our center were included as an external validation set. We proposed a novel staging system by sorting the substages yielded by a combination of T, N, and tumor grade based on their overall survival (OS) and grouping them into several stages. Prognostic homogeneity and discrimination were determined using the likelihood ratio χ2 and the linear trend χ2 test, respectively. Prognostic accuracies were evaluated by the area under the receiver operating characteristics curve (AUC). Results. Using the 8th AJCC system, the prognosis of patients within the same stage was quite heterogeneous among different substages. The multivariate Cox model identified the tumor grade (hazard ratio 1.333, 95% confidence interval 1.250–1.423, p<0.001) was an independent prognostic factor of the OS. In the training set, the AUC, homogeneity, and discriminatory ability were superior for the novel staging system than for the 8th AJCC system (0.642 vs. 0.615, 403.4 vs. 248.6, and 335.1 vs. 218.0, respectively). Similar results were observed in the internal and external validation sets. Conclusions. The novel staging system incorporating tumor grade into the 8th AJCC system was associated with better prognostic accuracy, homogeneity, and discriminatory ability among resectable PDAC patients. Moreover, the novel staging system also allowed possibly adjuvant chemotherapy decisions.
3D Dynamic Programming Approach to Functional Equations with Applications
Authors: Asif Awais , Khan Sami Ullah , Abdeljawad Thabet , Arshad Muahammad , Ali Amjad
Published: September 2020

This article demonstrates the graphical existence of a single fixed point while imposing the contractive condition of Chatterjea typeF-contraction onF-metric space (briefly asF-MS). We present two examples that verify the validity of the results given in the paper. The paper further explains the subsistence of the fixed point even if the contractive condition is valid only for a closed ball inside the space rather than imposing it on the wholeF-MS. Moreover, the application of the mentioned results in finding a single solution of functional equations is described that is widely used in computer programming and optimization.
Rare Presentation of Self-Limiting Kikuchi–Fujimoto Disease in Relapsing Nature
Authors: Servatyari Karo , Yazdanpanah Hero , Dalugama Chamara
Published: September 2020

Background. Kikuchi–Fujimoto disease (KFD) is a rare, benign, and self-limiting disease that is commonly associated with cervical lymphadenopathy and fever. The disease has a wide spectrum of clinical manifestations, and definitive diagnosis is based on the histological appearance in the excision biopsy of the lymph nodes. Recurrence of KFD is reported rarely.Case Presentation. A 56-year-old Iranian woman with a background history of thrombocytopenia presented with fever, malaise, loss of appetite, and weight loss with cervical lymphadenopathy. The excision biopsy of the cervical lymph nodes confirmed the diagnosis of KFD, and she made a full recovery with improvement of symptoms, regression of cervical lymph nodes, and normalization inflammatory markers. One year after remission, she presented with similar clinico-biochemical profile, and repeat biopsy confirmed KFD.Conclusion. Although the rate of recurrence of the disease is very low, the treating physician should consider the possibility and confirm it histologically.
Targeting CDK12 for Cancer Therapy: Function, Mechanism, and Drug Discovery
Authors: Liu Hui , Liu Kangdong , Dong Zigang
Published: September 2020

Cyclin-dependent kinase 12 (CDK12) is a member of the CDK family of proteins (CDK) and is critical for cancer development. Years of study into CDK12 have generated much information regarding the intricacy of its function and mechanism as well as inhibitors against it for oncological research. However, there remains a lack of understanding regarding the role of CDK12 in carcinogenesis and cancer prevention. An exhaustive comprehension of CDK12 will highly stimulate the development of new strategies for treating and preventing cancer. Here, we review the literature of CDK12, with a focus on its function, its role in signaling, and how to use it as a target for discovery of novel drugs for cancer prevention and therapy.
DNA Methylation in Peripheral Blood and Risk of Gastric Cancer: A Prospective Nested Case–control Study
Authors: Chamberlain James A , Dugué Pierre-Antoine , Bassett Julie K. , Milne Roger L. , Joo Jihoon E. , Wong Ee Ming , Brinkman Maree T. , Stuart Geoffrey W. , Boussioutas Alex , Southey Melissa C. , Giles Graham G. , Mitchell Hazel , English Dallas R. , Hodge Allison M.
Published: September 2020

DNA methylation in peripheral blood is a potential biomarker of gastric cancer risk which could be used for early detection. We conducted a prospective case–control study nested within the Melbourne Collaborative Cohort Study. Genomic DNA was prepared from blood samples collected a median of 12 years before diagnosis for cases (N = 168). Controls (N = 163) were matched to cases on sex, year of birth, country of birth, and blood sample type using incidence density sampling. Genome-wide DNA methylation was measured using the Infinium HumanMethylation450K Beadchip. Global measures of DNA methylation were defined as the median methylation M value, calculated for each of 13 CpG subsets representing genomic function, mean methylation and location, and reliability of measurement. Conditional logistic regression was conducted to assess associations between these global measures of methylation and gastric cancer risk, adjusting for Helicobacter pylori and other potential confounders. We tested nonlinear associations using quintiles of the global measure distribution. A genome-wide association study of DNA methylation and gastric cancer risk was also conducted (N = 484,989 CpGs) using conditional logistic regression, adjusting for potential confounders. Differentially methylated regions (DMR) were investigated using the R package DMRcate. We found no evidence of associations with gastric cancer risk for individual CpGs or DMRs (P > 7.6 × 10−6). No evidence of association was observed with global measures of methylation (OR 1.07 per SD of overall median methylation; 95% confidence interval, 0.80–1.44; P = 0.65). We found no evidence that blood DNA methylation is prospectively associated with gastric cancer risk.

Prevention Relevance: We studied DNA methylation in blood to try and predict who was at risk of gastric cancer before symptoms developed, by which stage survival is poor. We did not find any such markers, but the importance of early diagnosis in gastric cancer remains, and the search for markers continues.
A Randomized Controlled Trial on Efficacy of Surgical Excision of Nondysplastic Leukoplakia to Prevent Oral Cancer
Authors: Arduino Paolo G. , Lodi Giovanni , Cabras Marco , Macciotta Alessandra , Gambino Alessio , Conrotto Davide , Karimi Dora , Haddad Giorgia El , Carbone Mario , Broccoletti Roberto
Published: September 2020

The aim of this study was to evaluate the effectiveness of surgical excision to prevent cancer in patients with nondysplastic oral leukoplakia (OL). This study was the first randomized controlled clinical trial comparing surgical treatment with standard care in this group of patients. Patients were divided into two groups. The first group underwent standard care, that is smoking counseling, follow-up visits every 6 months, and control biopsy when indicated. The second group underwent surgical excision, together with standard care. Oral cancer onset was the primary outcome; secondary outcomes included healing, recurrence after surgery, onset of new lesions, and worsening of the primary lesions. The differences in distribution of the patients' and lesions' characteristics were investigated through nonparametrical tests (Wilcoxon rank-sum and Fisher exact). Univariate and multivariate logistic regressions have been performed to estimate the odds ratio of the treatment on the recurrence or worsening of the lesions. A total of 260 patients took part in the study of which 132 were women (50.8%); during the follow-up period, two subjects developed oral cancer, one for each arm. Surgical treatment, when compared with standard care, was associated with a lower probability of the treated zone to remain healed during the follow up period (OR = 7.43; 95% confidence interval, 2.96–22.66). In conclusion, it is possible to assumed that regular clinical follow-up could be considered a reliable standard of care among patients with nondysplastic OLs.

Prevention Relevance: Oral white patches can transform into cancer and none has provided clinical guidelines to prevent it. For the first time ever, we have showed that the clinical follow up of non dysplastic lesions was able to provide benefits if compared with surgical excision.
Deep Learning to Estimate RECIST in Patients with NSCLC Treated with PD-1 Blockade
Authors: Arbour Kathryn C. , Luu Anh Tuan , Luo Jia , Rizvi Hira , Plodkowski Andrew J. , Sakhi Mustafa , Huang Kevin B. , Digumarthy Subba R. , Ginsberg Michelle S. , Girshman Jeffrey , Kris Mark G. , Riely Gregory J. , Yala Adam , Gainor Justin F. , Barzilay Regina , Hellmann Matthew D.
Published: September 2020

Real-world evidence (RWE), conclusions derived from analysis of patients not treated in clinical trials, is increasingly recognized as an opportunity for discovery, to reduce disparities, and to contribute to regulatory approval. Maximal value of RWE may be facilitated through machine-learning techniques to integrate and interrogate large and otherwise underutilized datasets. In cancer research, an ongoing challenge for RWE is the lack of reliable, reproducible, scalable assessment of treatment-specific outcomes. We hypothesized a deep-learning model could be trained to use radiology text reports to estimate gold-standard RECIST-defined outcomes. Using text reports from patients with non–small cell lung cancer treated with PD-1 blockade in a training cohort and two test cohorts, we developed a deep-learning model to accurately estimate best overall response and progression-free survival. Our model may be a tool to determine outcomes at scale, enabling analyses of large clinical databases.

Significance:

We developed and validated a deep-learning model trained on radiology text reports to estimate gold-standard objective response categories used in clinical trial assessments. This tool may facilitate analysis of large real-world oncology datasets using objective outcome metrics determined more reliably and at greater scale than currently possible.

This article is highlighted in the In This Issue feature, p. 1
Spontaneous Tumor Lysis Syndrome
Authors: Wesemüller Wiebke , Taverna Christian
Published: September 2020

Tumor lysis syndrome (TLS) is a hemato-oncological emergency characterized by metabolic and electrolyte imbalances which are associated with disintegrating tumor cells. The syndrome is frequently observed when starting cytotoxic treatment of hematological malignancies, while the incidence of spontaneous tumor lysis prior to the start of tumor therapy is rare. Here, we present a case of spontaneous TLS in a male patient who was referred with unspecific symptoms and suspected metastatic malignancy. He developed acute renal failure before the diagnosis of a high-grade B-cell lymphoma (double hit lymphoma) and start of therapy. Although the course of TLS would have required intensive care, the patient rejected such treatment for personal reasons and died soon after the discontinuation of therapy. The case emphasizes the life-saving relevance of early detection and appropriate treatment of TLS. It also demonstrates the importance of actively screening for TLS, primarily in patients with malignant diseases and high tumor load, even if they are not receiving cytotoxic therapy.
Invasive Cancer Confined to the Nipple of the Conserved Breast: A Case Report
Authors: Kitahara Miyuki , Hozumi Yasuo , Takeuchi Naoto , Ichinohe Satoko , Machinaga Mitsuki , Iijima Tatsuo
Published: September 2020

Invasive breast cancer deriving from the milk duct and lobule that develops in the nipple is extremely rare, except in Paget’s disease and skin cancer. This is the second reported case of the development of invasive cancer confined to the nipple after breast-conserving surgery. A 69-year-old woman visited our department due to redness, swelling, and bloody discharge of the right nipple in the last month. A needle biopsy was suggestive of invasive ductal carcinoma; we performed a removal surgery of the right residual breast tissue and a second sentinel lymph node biopsy. She underwent these procedures 10 years previously as well. Thus, we diagnosed the present lesion as a local recurrence, but it was unknown whether the lesion was a true recurrence or second cancer, namely, metachronal ipsilateral breast cancer. The present case helps promote awareness that invasive cancer rarely develops in the nipple after conserving surgery. Patients should be encouraged to visit a medical facility if experiencing skin changes and swelling of the nipple. Additionally, breast cancer patients must be carefully selected for breast-conserving surgery; failure to do so may later result in nipple-specific local recurrence.
Health-Related Quality of Life and Survival in Prostate Cancer Patients in a Real-World Setting
Authors: Bergius Susanne , Roine Risto P. , Taari Kimmo , Sintonen Harri
Published: September 2020

Objective: To analyze the health-related quality of life (HRQoL) and survival of real-world prostate cancer (PC) patients and to calculate quality-adjusted life-years (QALYs) experienced under different treatment strategies. Materials and Methods: PC patients undergoing active surveillance (n = 226), radiation treatment (n = 280), surgery (n = 299), or hormonal treatment (n = 62) responded to the generic 15-dimensional (15D) HRQoL questionnaire at the time of the diagnosis and were followed up 3, 6, 12, and 24 months later. QALYs experienced during the follow-up were calculated for each treatment group, and variables associated with survival were analyzed using Cox proportional hazards models. Results: HRQoL was stable during the first 2 years after diagnosis in all other treatment groups, except in patients treated with hormonal therapy. The overall survival within 6.5-year follow-up time was 84.4%. The number of QALYs experienced during the 2-year follow-up was similar in patients in active surveillance (1.790), surgery (1.784), and radiation groups (1.767), but significantly lower in the hormonal therapy group (1.665). Conclusions: Patients receiving hormonal treatment had significantly impaired HRQoL and survival compared with other treatments. Although the number of QALYs experienced was similar in the 3 other treatment lines, there were marked differences between treatment lines on some 15D dimensions.
Descriptive Analysis of Cross-Reactive Anaphylaxis as a Different Clinical Subtype of Nonsteroidal Anti-Inflammatory Drug (NSAID) Hypersensitivity
Authors: Vásquez Laura del Mar , Silva Diana Lucia , Ramírez Luis Fernando , Olaya Manuela , Serrano Carlos Daniel
Published: September 2020

Introduction: The European Network of Drug Allergy and the European Academy of Allergy and Clinical Immunology have classified hypersensitivity reactions induced by nonsteroidal anti-inflammatory drugs (NSAIDs) into 5 phenotypes according to the pathophysiology, clinical manifestations, number of drugs involved, and the presence of underlying diseases. This classification does not include anaphylaxis as part of NSAID cross-reactivity. The objective of this study was to characterize a group of patients with anaphylactic NSAID cross-reactivity. Method: This was a retrospective, descriptive, observational study. Patients who developed anaphylaxis to one NSAID plus another acute reaction (anaphylactic or not) to at least one other NSAID of a different chemical group were included. Demographic and clinical characteristics and the diagnostic approach were studied. Results: A total of 38 patients were included, 28 (73.7%) of whom were women. The mean age was 40 ± 17.7 years. The main organs affected in the anaphylactic reaction were the skin and the respiratory system, occurring in 35 (92.1%) and 33 (86.8%) patients, respectively. Thirty-two (84.3%) patients presented with cutaneous and respiratory involvement simultaneously. The main anti-inflammatory agent involved in anaphylactic reactions was acetylsalicylic acid in 9 (23.7%) patients, followed by dipyrone in 8 (21.1%). The most frequent allergic comorbidity was rhinitis in 20 (52%) patients. Skin tests were performed in 15 (39.5%) patients, showing positivity in 12 (80%), mainly to mites. A total of 36 of 38 patients were challenged with alternative drugs, and 35 (97.2%) tolerated meloxicam and/or etoricoxib. Conclusion: In the present study, NSAID cross-anaphylaxis was more frequent in women, and acetylsalicylic acid and dipyrone were the main triggers. Rhinitis was the main allergic comorbidity, and there was a high incidence of atopy. The majority tolerated selective COX-2 NSAIDs.
The Causal Relationship between Eating Animals and Viral Epidemics
Authors: Reddy Bhaskara L. , Saier Milton H., Jr.
Published: September 2020

For decades it has been known that infectious agents including pathogenic protozoans, bacteria, and viruses, adapted to a particular animal host, can mutate to gain the ability to infect another host, and the mechanisms involved have been studied in great detail. Although an infectious agent in one animal can alter its host range with relative ease, no example of a plant virus changing its host organism to an animal has been documented. One prevalent pathway for the transmission of infectious agents between hosts involves ingestion of the flesh of one organism by another. In this article we document numerous examples of viral and prion diseases transmitted by eating animals. We suggest that the occurrence of cross-species viral epidemics can be substantially reduced by shifting to a more vegetarian diet and enforcing stricter laws that ban the slaughter and trade of wild and endangered species.
Ten-Year Differences in Women’s Awareness Related to Coronary Heart Disease: Results of the 2019 American Heart Association National Survey: A Special Report From the American Heart Association
Authors: Cushman Mary , Shay Christina M. , Howard Virginia J. , Jiménez Monik C. , Lewey Jennifer , McSweeney Jean C. , Newby L. Kristin , Poudel Ram , Reynolds Harmony R. , Rexrode Kathryn M. , Sims Mario , Mosca Lori J. ,   On behalf of the American Heart Association
Published: September 2020

Background:

High awareness that cardiovascular disease is the leading cause of death (LCOD) among women is critical to prevention. This study evaluated longitudinal trends in this awareness among women.

Methods and Results:

Online surveys of US women (≥25 years of age) were conducted in January 2009 and January 2019. Data were weighted to the US population distribution of sociodemographic characteristics. Multivariable logistic regression was used to evaluate knowledge of the LCOD. In 2009, awareness of heart disease as the LCOD was 65%, decreasing to 44% in 2019. In 2019, awareness was greater with older age and increasing education and lower among non-White women and women with hypertension. The 10-year awareness decline was observed in all races/ethnicities and ages except women ≥65 years of age. The greatest declines were among Hispanic women (odds ratio of awareness comparing 2019 to 2009, 0.14 [95% CI, 0.07–0.28]), non-Hispanic Black women (odds ratio, 0.31 [95% CI, 0.19–0.49]), and 25- to 34-year-olds (odds ratio, 0.19 [95% CI, 0.10–0.34]). In 2019, women were more likely than in 2009 to incorrectly identify breast cancer as the LCOD (odds ratio, 2.59 [95% CI, 1.86–3.67]), an association that was greater in younger women. Awareness of heart attack symptoms also declined.

Conclusions:

Awareness that heart disease is the LCOD among women declined from 2009 to 2019, particularly among Hispanic and non-Hispanic Black women and in younger women (in whom primordial/primary prevention may be most effective). An urgent redoubling of efforts by organizations interested in women’s health is required to reverse these trends.
Glucagon-Like Peptide 1 Receptor Agonists and Heart Failure
Authors: Khan Muhammad Shahzeb , Fonarow Gregg C. , McGuire Darren K. , Hernandez Adrian F. , Vaduganathan Muthiah , Rosenstock Julio , Handelsman Yehuda , Verma Subodh , Anker Stefan D. , McMurray John J.V. , Kosiborod Mikhail N. , Butler Javed
Published: September 2020

With worsening epidemiological trends for both the incidence and prevalence of type 2 diabetes mellitus (T2DM) and heart failure (HF) worldwide, it is critical to implement optimal prevention and treatment strategies for patients with these comorbidities, either alone or concomitantly. Several guidelines and consensus statements have recommended glucagon-like peptide-1 receptor agonists and sodium-glucose cotransporter type 2 inhibitors as add-ons to lifestyle interventions with or without metformin in those at high atherosclerotic cardiovascular disease risk. However, these recommendations are either silent about HF or fail to differentiate between the prevention of HF in those at risk versus the treatment of individuals with manifest HF. Furthermore, these documents do not differentiate among those with different HF phenotypes. This distinction, even though important, may not be critical for sodium-glucose cotransporter type 2 inhibitors in view of the consistent data for benefit for both atherosclerotic cardiovascular disease– and HF-related outcomes that have emerged from the regulatory-mandated cardiovascular outcome trials for all sodium-glucose cotransporter type 2 inhibitors and the recent DAPA-HF trial (Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction)demonstrating the benefit of dapagliflozin on HF-related outcomes in patients with HF with reduced ejection fraction with or without T2DM. However, the distinction may be crucial for glucagon-like peptide-1 receptor agonists and other antihyperglycemic agents. Indeed, in several of the new statements, glucagon-like peptide-1 receptor agonists are suggested treatment not only for patients with T2DM and atherosclerotic cardiovascular disease, but also in those with manifest HF, despite a lack of evidence for the latter recommendation. Although glucagon-like peptide-1 receptor agonists may be appropriate to use in patients at risk for HF, mechanistic insights and observations from randomized trials suggest no clear benefit on HF-related outcomes and even uncertainty regarding the safety in those with HF with reduced ejection fraction. Conversely, theoretical rationales suggest that these agents may benefit patients with HF with preserved ejection fraction. Considering that millions of patients with T2DM have HF, these concerns have public health implications that necessitate the thoughtful use of these therapies. Achieving this aim will require dedicated trials with these drugs in both patients who have HF with reduced ejection fraction and HF with preserved ejection fraction with T2DM to assess their efficacy, safety, and risk-benefit profile.
Association of Hypertriglyceridemia with All‐Cause Mortality and Atherosclerotic Cardiovascular Events in a Low‐Risk Italian Population: The TG‐REAL Retrospective Cohort Analysis
Authors: Arca Marcello , Veronesi Chiara , D’Erasmo Laura , Borghi Claudio , Colivicchi Furio , De Ferrari Gaetano Maria , Desideri Giovambattista , Pontremoli Roberto , Temporelli Pier Luigi , Perrone Valentina , Degli Esposti Luca , Montinari Caterina , Pisterna Alessia , Demontis Stefania , Senesi Ilenia
Published: September 2020

Background

Evidence regarding the relationships among high plasma triglycerides (TG), all‐cause mortality, and atherosclerotic cardiovascular disease (ASCVD) events in low‐to‐moderate risk individuals is limited. The aim of this study was to determine whether the presence of high TG levels influences the risk of all‐cause mortality and ASCVD events in a population cohort followed in the real‐world clinical setting.

Methods and Results

A retrospective longitudinal cohort analysis using administrative databases of 3 Italian Local Health Units was performed. All individuals with at least one TG measurement between January 1, 2010 and December 31, 2015 were followed through December 2016. Outcome measures included incident ASCVD events and all‐cause mortality. Individuals with normal TG levels (<150 mg/dL) were compared with those with high (150–500 mg/dL) and very high TG (>500 mg/dL). 158 042 individuals (142 289 with normal, 15 558 with high, and 195 with very high TG) were considered. In the whole cohort, the overall incidence rates of ASCVD and all‐cause mortality were 7.2 and 17.1 per 1000 person‐years, respectively. After multivariate adjustment for potential confounders, individuals with high and very high TG showed a significantly increased risk of all‐cause mortality (hazard ratio [HR]=1.49 [95% confidence interval (CI) 1.36–1.63],
P
<0.001, and HR=3.08 [95% CI 1.46–6.50],
P
<0.01, respectively) and incident ASCVD events (HR=1.61 [95% CI 1.43–1.82],
P
<0.001, and HR=2.30 [95% CI 1.02–5.18],
P
<0.05, respectively) as compared to those with normal TG.

Conclusions

Moderate‐to‐severe elevation of TG is associated with a significantly increased risk of all‐cause mortality and ASCVD events in a large cohort of low‐to‐moderate cardiovascular risk individuals in a real‐world clinical setting.
Effects of Home‐Based Cardiac Rehabilitation on Time to Enrollment and Functional Status in Patients With Ischemic Heart Disease
Authors: Schopfer David W. , Whooley Mary A. , Allsup Kelly , Pabst Mark , Shen Hui , Tarasovsky Gary , Duvernoy Claire S. , Forman Daniel E.
Published: September 2020

Background

Cardiac rehabilitation is an established performance measure for adults with ischemic heart disease, but patient participation is remarkably low. Home‐based cardiac rehabilitation (HBCR) may be more practical and feasible, but evidence regarding its efficacy is limited. We sought to compare the effects of HBCR versus facility‐based cardiac rehabilitation (FBCR) on functional status in patients with ischemic heart disease.

Methods and Results

This was a pragmatic trial of 237 selected patients with a recent ischemic heart disease event, who enrolled in HBCR or FBCR between August 2015 and September 2017. The primary outcome was 3‐month change in distance completed on a 6‐minute walk test. Secondary outcomes included rehospitalization as well as patient‐reported physical activity, quality of life, and self‐efficacy. Characteristics of the 116 patients enrolled in FBCR and 121 enrolled in HBCR were similar, except the mean time from index event to enrollment was shorter for HBCR (25 versus 77 days;
P
<0.001). As compared with patients undergoing FBCR, those in HBCR achieved greater 3‐month gains in 6‐minute walk test distance (+95 versus +41 m;
P
<0.001). After adjusting for demographics, comorbid conditions, and indication, the mean change in 6‐minute walk test distance remained significantly greater for patients enrolled in HBCR (+101 versus +40 m;
P
<0.001). HBCR participants reported greater improvements in quality of life and physical activity but less improvement in exercise self‐efficacy. There were no deaths or cardiovascular hospitalizations.

Conclusions

Patients enrolled in HBCR achieved greater 3‐month functional gains than those enrolled in FBCR. Our data suggest that HBCR may safely derive equivalent benefits in exercise capacity and overall program efficacy in selected patients.

Registration

URL:
https://www.clini​caltr​ials.gov
; Unique identifier: NCT02105246.
Degeneration of Bioprosthetic Heart Valves: Update 2020
Authors: Kostyunin Alexander E. , Yuzhalin Arseniy E. , Rezvova Maria A. , Ovcharenko Evgeniy A. , Glushkova Tatiana V. , Kutikhin Anton G.
Published: September 2020

The implantation of bioprosthetic heart valves (BHVs) is increasingly becoming the treatment of choice in patients requiring heart valve replacement surgery. Unlike mechanical heart valves, BHVs are less thrombogenic and exhibit superior hemodynamic properties. However, BHVs are prone to structural valve degeneration (SVD), an unavoidable condition limiting graft durability. Mechanisms underlying SVD are incompletely understood, and early concepts suggesting the purely degenerative nature of this process are now considered oversimplified. Recent studies implicate the host immune response as a major modality of SVD pathogenesis, manifested by a combination of processes phenocopying the long‐term transplant rejection, atherosclerosis, and calcification of native aortic valves. In this review, we summarize and critically analyze relevant studies on (1) SVD triggers and pathogenesis, (2) current approaches to protect BHVs from calcification, (3) obtaining low immunogenic BHV tissue from genetically modified animals, and (4) potential strategies for SVD prevention in the clinical setting.
The Middle-Income Trap 2.0: The Increasing Role of Human Capital in the Age of Automation and Implications for Developing Asia
Authors: Glawe Linda , Wagner Helmut
Published: September 2020

We modify the concept of the middle-income trap (MIT) against the background of the Fourth Industrial Revolution and the (future) challenges of automation (creating the concept of the “MIT 2.0”) and discuss the implications for developing Asia. In particular, we analyze the impacts of automation, artificial intelligence, and digitalization on the growth drivers of emerging market economies and the MIT mechanism. Our findings suggest that improving human capital accumulation, particularly the upgrading of skills needed with the rapid advance of automation, will be key success factors for overcoming the MIT 2.0.
Revisiting Complementarity between Japanese FDI and the Import of Intermediate Goods: Agglomeration Effects and Parent-firm Heterogeneity
Authors: Ito Tadashi , Matsuura Toshiyuki , Yang Chih-Hai
Published: September 2020

This study revisits the nexus between foreign direct investment (FDI) and international trade in the dynamic perspective, focusing on intermediate goods imports of affiliates of Japanese firms operating in China. To examine the effect of the formation of the agglomeration and the recent FDI made by small firms, both of which have been overlooked in the literature, we construct a unique parent-affiliate matched panel data set of trade in intermediate goods, and estimate a discrete-time hazard model over the 2000–06 period. We found that affiliates owned by firms in agglomerated regions in Japan have a shorter duration of trade in intermediate goods compared with affiliates owned by smaller Japanese firms.
From Material to Infrastructure: Germaine Krull's Métal
Authors: Boersma Max
Published: September 2020

This article reexamines Germaine Krull's seminal 1928 photo book Métal, tracing the implications of the speculative analogy drawn by the project between metal and photography. Following this analogy through nineteenth- and early-twentieth-century architectural discourse, it newly situates the photographer's investigation against Sigfried Giedion's contemporaneous theorizations of iron construction and modern photography. Rather than critiquing or celebrating industry, Krull focuses on metal as it manifests the peculiar and fraught experience of living amid large-scale technical systems. In a singular way, Métal mobilizes its driving analogy to invoke—and, moreover, to theorize photographically—the infrastructures organizing Western European modernity.
Morphological characteristics and phylogenetic analyses reveal Antrodia yunnanensis sp. nov. (Polyporales, Basidiomycota) from China

Authors: HAN MEI-LING , AN QI , FU WEN-XIAN , CHENG XUAN , BU TIAN , LI WEN-JING
Published: September 2020

A new polypore, Antrodia yunnanensis, collected from southwestern China, is described and illustrated based on morphological characteristics and molecular evidence. It is characterized by annual, resupinate basidiocarps with greyish blue to dark greyish blue pore surface upon drying, round to angular pores measuring 2–3 per mm, a dimitic hyphal system with clamped generative hyphae, subicular hyphae bearing fine crystals, and cylindrical, thin-walled, smooth basidiospores measuring 7–9.9 × 2.5–3.1 µm. Molecular phylogeny inferred from ITS and nLSU sequence data showed that samples of A. yunnanensis formed a distinctive lineage in Antrodia sensu lato, and it nested a sister group with A. tropica.
Mericarp morphology of the genus Origanum (Lamiaceae) and its taxonomic significance in Turkey

Authors: ECEVİT-GENÇ GÜLAY , ÖZCAN TANER , DİRMENCİ TUNCAY , ARABACI TURAN
Published: September 2020

Origanum is a well-known genus that is widely distributed and comprises many hybrids and endemic species in Turkey. Some morphological and molecular studies in the literature have aimed to clarify infrageneric or sectional classification of the genus. However, studies regarding the shape, size, and color of mericarps of Origanum taxa remain limited. The mericarp micromorphology of 30 taxa, including 7 hybrids of the genus Origanum, were evaluated herein using both stereo microscopy and scanning electron microscopy (SEM) to determine some useful features for taxonomical classification of the genus. The shapes of mericarps are usually ellipsoid, rarely ellipsoid-oblong, obovoid, broadly obovoid, while the color of mericarps vary from shades of brown to reddish. A significant variation was observed in the surface ornamentation of mericarps, which was mainly useful at the sectional and species level. Also determined were 2 main types: I and II, and 5 subtypes: pusticulate, reticulate-ruminate, reticulate-foveate, ruminate, and foveate. The micromorphological characters of mericarps, in addition to their morphological features, will contribute taxonomically to the classification of the sections of the genus Origanum and separation of the species within the sections. In addition, these characters will be useful to understand the effect of hybridization on variations in the micromorphological characters. This was the first detailed study on the mericarp micromorphology of the genus Origanum and its taxonomic implications.
Description of two new species of Dinetus Panzer, 1806 (Hymenoptera: Crabronidae: Dinetinae) with key to species
Authors: MOKROUSOV MIKHAIL V. , KHEDHER HASSIB B.
Published: September 2020

Two new species—Dinetus rakhimovi Mokrousov et Khedher, sp. nov. from Uzbekistan and Dinetus tunisiensis Khedher et Mokrousov, sp. nov. from Tunisia are described and illustrated. The total number of Dinetus is increased so to 14 species in the world. An identification key to all species is given.
The Global Land Surface Satellite (GLASS) Product Suite
Authors: Liang Shunlin , Cheng Jie , Jia Kun , Jiang Bo , Liu Qiang , Xiao Zhiqiang , Yao Yunjun , Yuan Wenping , Zhang Xiaotong , Zhao Xiang , Zhou Ji
Published: September 2020

The Global Land Surface Satellite (GLASS) product suite currently contains 12 products, including leaf area index, fraction of absorbed photosynthetically active radiation, fraction of green vegetation coverage, gross primary production, broadband albedo, broadband longwave emissivity, downward shortwave radiation and photosynthetically active radiation, land surface temperature, downward and upwelling thermal radiation, all-wave net radiation, and evapotranspiration. These products are generated from the Advanced Very High Resolution Radiometer and Moderate Resolution Imaging Spectroradiometer satellite data. Their unique features include long-term temporal coverage (many from 1981 to the present), high spatial resolutions of the surface radiation products (1 km and 0.05°), spatial continuities without missing pixels, and high quality and accuracy based on extensive validation using in situ measurements and intercomparisons with other existing satellite products. Moreover, the GLASS products are based on robust algorithms that have been published in peer-reviewed literature. Herein, we provide an overview of the algorithm development, product characteristics, and some preliminary applications of these products. We also describe the next steps, such as improving the existing GLASS products, generating more climate data records (CDRs), broadening product dissemination, and fostering their wider utilization. The GLASS products are freely available to the public.
The Daoist Tradition in China’s Strategic Culture: Understanding the Pragmatic Dimensions of China’s Behavioural Trends in the International System
Authors: Anand. V
Published: September 2020

China’s strategic culture has mostly been understood from the competing prisms of Confucianism and realpolitik traditions. However, there is a need to go beyond this binary approach to explore the more nuanced civilisational basis of China’s strategic thinking. It is in this context that the role of Daoism becomes significant in understanding China’s behavioural patterns. The Daoist strategic tradition has been found to be a highly cogent system based on five key pillars—strategic rationalism, strategic aloofness, strategic optimisation, strategic restraint and strategic flexibility. These aspects have been found reflected in various key instances of China’s strategic practice, demonstrating its relevance for understanding China’s strategic culture.
Enhanced character embedding for Chinese named entity recognition
Authors: Jia Bingjing , Wu Zhongli , Wu Bin , Liu Yutong , Zhou Pengpeng
Published: September 2020

Traditional named entity recognition methods mainly explore the application of hand-crafted features. Currently, with the popularity of deep learning, neural networks have been introduced to capture deep features for named entity recognition. However, most existing methods only aim at modern corpus. Named entity recognition in ancient literature is challenging because names in it have evolved over time. In this paper, we attempt to recognise entities by exploring the characteristics of characters and strokes. The enhanced character embedding model, named ECEM, is proposed on the basis of bidirectional encoder representations from transformers and strokes. First, ECEM can generate the semantic vectors dynamically according to the context of the words. Second, the proposed algorithm introduces morphological-level information of Chinese words. Finally, the enhanced character embedding is fed into the bidirectional long short term memory-conditional random field model for training. To explore the effect of our proposed algorithm, experiments are carried out on both ancient literature and modern corpus. The results indicate that our algorithm is very effective and powerful, compared with traditional ones.