bluuebunny/crossref_metadata_2025 huggingface dataset:
The Arabic Version of MELASQoL Scale: Translation, Cultural Adaptation, with Assessment of Reliability and Validity
Authors: Abou-Taleb Doaa AE , EA Moubasher Alaa , K Ibrahim Ahmed , MK Youssef Eman
Published: November 2021

Background: Melasma has significant emotional and psychological effects and significant negative impact on patients’ quality of life (QoL). Melasma QoL Scale (MELASQoL) is a specific questionnaire that has been developed to assess the effect of melasma on patient’s QoL. Objective: Translation, cultural adaptation, reliability and validation of melasma specific QoL sale (MELASQoL) into Arabic. Patients and Methods: A total of 65 adult Egyptian female patients with melasma aged ≥18 years old with skin phototypes type III-V were enrolled in this study. Wood’s light was used for determination of the type of melasma either epidermal, dermal or mixed. Melasma severity was assessed by using the melasma area and severity index (MASI) score and the new modified score (mMASI). The impact of melasma on QoL was evaluated using the Arabic version of MELASQoL scale after translation and cultural adaptation according to the WHO guidelines. The questionnaire’s reliability and validity was assessed. Results: The internal consistency for the 10-item of the MELASQoL-A scale was excellent; Intra-class Correlation Coefficient (ICC) = 0.914 and Cronbach’s alpha coefficient (Cronbach α = 0.944) indicating high reliability of the developed Arabic version. There was significant positive correlation between the MELASQoL-A scale and the MASI score (r= 0.41; p= 0.0027), and the mMASI score (r = 0.36; p= 0.0032). Conclusion: The Arabic version of the MELASQoL scale was found to be a reliable and valid measure for evaluating the QoL among Egyptian melasma patients, supporting its use in Arab communities.
Flushing Associated with Prolonged Mask Wearing During Covid-19 Pandemic Among the General Population
Authors: Zhang Zhenying , Shi Jialiang , Han Changxu , Chen Yan
Published: November 2021

Wearing mask was encouraged to prevent dispersal of droplets and to reduce the risks of environmental contamination by COVID-19 during COVID-19 pandemic. However, we noticed a rise in the initial attack, relapse or exacerbation of flushing among general population due to long-time mask wearing. In this manuscript, we reported the characters of the mask-related flushing, and attempted to explain the reasons and put forward some precautions for that. We suggested that general public should be aware of proper and rational mask wearing to avoid inducing and aggravating flushing. We hope that our findings will contribute to increase the awareness about mask related flushing.
Nature Reviews Endocrinology: Acromegaly
Authors: Obi Chike , Achebe Claudio
Published: November 2021

Acromegaly is a rare disease most often caused by the prolonged secretion of excess growth hormone from a pituitary adenoma. The disease is associated with multiple significant comorbidities and increased mortality. The delay to diagnosis is often long. This may be because of low disease awareness among health care professionals, the insidious onset of differentiating features, and because patients are likely to present with complaints typical of other conditions more frequently seen in primary care. Early identification of acromegaly facilitates prompt treatment initiation and may minimize the permanent effects of excess growth hormone. The primary treatment for many patients will be pituitary surgery, although not all patients will be eligible for surgery or achieve a surgical cure
Innervation of the Thymus Gland: A Short Review of Function and Histology
Authors: Babalola Bolaji
Published: November 2021

The thymus, a primary lymphoid organ and the initial site for development of T cell immunological function, is morphologically similar across species. It is actually an epithelial organ in which its epithelial cells provide a framework containing T cells as well as smaller numbers of other lymphoid cells. A symbiotic interaction exists between the thymic microinvironment and developing T cells, and the specificity of T cell release into the systemic circulation is under thymic control. The thymic cortex in a young animal is heavily populated by developing T cells along with a smaller proportion of associated epithelial cells. Larger, more mature T cells are found in the medulla where epithelial and other cell types are more abundant. Understanding normal morphological features of the thymus and their perturbations provides a cornerstone to assessing immune system function.
Re-Print Non-Aspirin Nsaids Use is Associated with Lowering of Liver Fibrosis Scores in Patients with Fatty Liver Disease
Authors: Ogbu Ikechukwu , Akhondi Hossein , Ayutyanont Napatkamon , Manov Andre
Published: November 2021

Only a few studies are available with appropriate data on the effects of non-aspirin, non-steroidal anti-inflammatory drugs (NSAID’s) use in patients with fatty liver disease. We performed a retrospective study of 1347 patients with imaging studies that showed fatty liver disease from 2016 through 2019. Then we determined the change in validated indices using Fibrosis-4 (FIB4) and NAFLD fibrosis score (NFS). Patient’s clinical information, including NSAID’s use, was collected at baseline and then yearly. Using generalized linear model, we estimated the association between the non-aspirin NSAID’s use and change in the baseline indices. Non-aspirin NSAID’s use was found to be associated with significant lowering of FIB-4 score (0.596 units lower, p-value <0.0001) and NFS score (0.431 units lower, p-value 0.0027) every year. In this retrospective study of patients with fatty liver disease found on imaging, non-aspirin NSAID’s use was associated with lowering of fibrotic scores, suggesting that non- aspirin containing NSAID’s use might be associated with a lower risk for advanced fibrosis in patients with fatty liver disease. Summary: Non-aspirin NSAID’s use is associated with lowering of hepatic fibrosis scores in patients with fatty liver disease.
A Systematic Review: Predict the COVID-19 Severity by HDL and Triglycerides Level
Authors: Setiawan Nathan Daniel , Yumilia Hoo
Published: November 2021

Lipids are a major component in the process of SARS-CoV-2 infection. The clinical significance of plasma lipid profiles during COVID-19 has been described in several studies to date. The purpose of this mini-review is to summarize previous research studies regarding the association of plasma lipid profile with the clinical severity of SARS-CoV-2 infection. This edition presents mini-review reports on research studies related to LDL and TG levels that can predict severity in patients with COVID-19. Atherogenic dyslipidemia that occurs during infection is reported to be very strongly correlated with a more severe prognosis in COVID-19 infection. Therefore, lipid profiles should be performed to indicate acute and measurable inflammation in COVID-19 patients, and fish oil and statin therapy should also be considered to improve the condition.
Obesity – Can Allium fistulosum L. be a remedy?
Authors: Rahmatullah Mohammed , Jahan Rownak
Published: November 2021

Obesity is one of the major problems facing human beings at present. Because of the consumption of refined sugar and foods rich in carbohydrates, as well as adoption of a more sedentary lifestyle (often by necessity as is the case with most office workers), people in all countries are increasingly getting obese, which in turn is leading to other disorders like diabetes and cardiovascular complications. Existing conventional drugs have adverse side-effects, which is the major cause for scientists to look towards the plant kingdom for discovery of newer drugs with less or no side-effects. The Allium genera of plants are widely known for their medicinal properties, in particular Allium cepa (onion) and Allium sativum (garlic), whose beneficial actions include anti-obesity effects. In this mini review, we examine a lesser known plant of the Allium genera, namely Allium fistulosum L. and review its anti-obesity potential. The conclusion of the present study is that the plant contains phytochemicals like ferulic acid and quercetin, which possess anti-obesity mechanisms of action thus rendering the plant to be of potential use against obesity.
Re-Print Cell Impact: Pathophysiological Mechanism of Sars-Cov-2 in the Olfactory and Gustatory System
Authors: Tafur Delgado Juan Esteban , Jesús Bravo Diz Geovanny , Humanes Moreno Katherine Stella
Published: November 2021

Smell and taste alterations are very common in patients with COVID 19, even when we are in an asymptomatic phase of the disease, it is reported that up to 80 to 90% of patients present anosmia and ageusia as a cardinal symptom of the disease. In this manuscript we will mention the alterations and the mode of action of the Sars-cov-2 virus at the level of the nasal and buccal fossae, taking into account the alterations at the cellular level as a result of this, based on current evidence, remembering that it is still unknown. A lot about this disease and the way this virus works.
Clinical Presentation of Primary Hyperparathyroidism in Lahore, Pakistan – A Single Center Study
Authors: Khalid Rizwan , Hassaan Muhammad , Raza Ali
Published: November 2021

Aim: To assess different clinical presentations and outcomes of primary hyperparathyroidism in Pakistan. Study Design: Retrospective cross-sectional study. Study Setting: East Surgical Ward, Mayo Hospital, Lahore. Duration: 2011 to 2016 Introduction: PHPT is a common endocrine condition with a wide range of clinical manifestations differing according to geographic. Discussion: The most common clinical presentation in our study was bone pains which were in contrast to the asymptomatic cases being most common manifestation in US and Western countries. 90% (n 36) of the patients had bony involvement while 47.5% (n 19) had renal involvement at the time of presentation. Conclusion: Due to lack of routine biochemical screening tests in developing countries, primary hyperparathyroidism is detected late.
Penerapan Metode Design Thinking terhadap Pemasaran Produk pada Coffee Shop Rimbun
Authors: Raja Ainya Alfatiha  , Sukoco Iwan
Published: November 2021

Dewasa ini antusiasme masyarakat terhadap produk kopi cukup meningkat, hal ini juga diiringi dengan peningkatan jumlah pertumbuhan coffee shop. Peningkatan jumlah coffee shop menandakan bahwa persaingan pada industri kopi akan semakin ketat. Sehingga pelaku bisnis perlu menentukan strategi untuk memasarkan produk. Salah satu cara yang mampu digunakan adalah design thinking, dengan menggunaka 5 tahapan empathize, define, ideate, prototype, serta test. Studi ini bersifat deskriptif kualitatif dengan memanfaatkan tipe penelitian studi literature. Pengumpulan informasi dalam penyusunan artikel ini diperoleh melalui data primer yakni wawancara dan observasi serta data sekunder yaitu buku, jurnal ilmiah, website, dll. Selain itu, artikel ini mengidentifikasi permasalahan menggunakan metode design thinking. Berdasarkan hasil yang diperoleh dari artikel ini, design thinking dapat dijadikan metode penentuan strategi pemasaran dan pengembangan bagi Coffee Shop Rimbun
Decolonising Arts and Culture in Belgium
Authors: Gossiaux Axel Mudahemuka
Published: November 2021

This contribution gives insight into the decolonisation of thought by presenting Black Out, a transmedia initiative located in the city of Liège in Belgium. Black Out is a project designed for promoting black music and culture and fighting against racism, principally through information technology and social media. I highlight how Black Out may participate in efforts for decolonising arts and culture in Belgium and Europe. To do so, I present a few contextual elements about racism and the postcolonial debate in Belgium before giving examples on how the projects of Black Out are in line with some of the driving forces of the decolonial approach.
ENVIRONMENTALLY SENSITIVE AREAS OF IRRIGATION LAND USE IN WESTERN SIBERIA
Authors:   Institute for Water and Environmental Problems of Siberian Branch of the Russian Academy of Sciences, Orlova I. V.
Published: November 2021

Purpose: to identify the main environmental problems in areas of intensive use of irrigated lands in Western Siberia and to study the relationship between their manifestations and the territorial specifics of the irrigation land use functioning. Materials and methods. The research was carried out on the basis of a systematic approach and comparative geographical analysis. The indicators characterizing the modern structure and territorial specifics of irrigated land use, and parameters reflecting the ecological state of irrigated lands and adjacent territories are studied. Discussions. It was found that the specifics of the identified environmental problems depends not only on type of irrigated lands use but also on the territorial differentiation of irrigated land use and its specialization. For suburban areas with potato and vegetable growing specialization, environmental problems arising as a result of higher intensification of irrigation land use and the proximity effect of Western Siberia metropolis have been identified, which predetermines a high degree of environmental pollution and a high level of land and water resources degradation. For areas with livestock specialization, located in the peripheral and most arid natural and climatic conditions, a great dependence of environmental problems on the irrational structure of irrigation land use and non-observance of norms and technologies for irrigation has been established. Conclusions. For better understanding of the environmental problems causes, it is necessary to study the relationship between their manifestations and the territorial specifics of the irrigation land use functioning. The results of this study can contribute to the search for ways of reducing the irrigation impact on the environment and the development of effective strategies for the sustainable development of irrigation land use in Western Siberia.
IMPROVING METHODOLOGICAL APPROACHES TO ASSESSING PRODUCTION EFFICIENCY OF IRRIGATED CROP PRODUCTION
Authors:   Stavropol State Agrarian University, Bannikova N. V. , Esaulko A. N. ,   Stavropol State Agrarian University, Vaytsekhovskaya S. S. ,   Stavropol State Agrarian University, Kostyuchenko T. N. ,   Stavropol State Agrarian University, Telnova N. N. ,   Stavropol State Agrarian University
Published: November 2021

Purpose: adjustment and expansion of evaluation items of economic efficiency of crop growing in the conditions of irrigated agriculture, taking into account its features. Materials and methods. In the process of evaluation, the classical method of investment analysis, the computational-constructive method, one-parameter analysis of the sensitivity of the hydro-land reclamation project to key risks using the parameter variation method were used. The materials characterizing the water management complex and its state support indicators in the Stavropol Territory are presented. The data from agricultural enterprises in Novoaleksandrovsky and Ipatovsky districts of Stavropol Territory were used in calculations. Results. Based on the analysis of the features of irrigated agriculture, their economic aspects are considered and the corresponding methodological approaches to conducting a comprehensive evaluation of the economic efficiency of irrigated agricultural production are proposed. The approbation of individual elements of the proposed methods using averaged factual data made it possible to illustrate the possibility of modeling economic efficiency in conditions of different irrigation methods, using the example of growing vegetable and fodder crops in dynamics, to conduct an investment analysis of a hydro-reclamation project, to characterize indicators for assessing the efficiency using – the identification of the key resources of crop production in conditions of irrigation – land and water, to identify the determining role of the risks of fluctuations in prices for vegetable products as a critical factor for one of the resulting indicators in the project analysis – the payback period of projects for the organization of irrigated agriculture. Conclusions. The proposed methodological complex allows for a more reasoned and multilateral substantiation of the feasibility of irrigation and land reclamation projects implementation, conducting a comparative analysis of their economic parameters, and predicting the resistance level to changes in the main risk factors.
SCIENTIFIC BASIS FOR DEVELOPING HYDRAULIC ENGINEERING STRUCTURES TO ENSURE THE RELIABILITY AND SAFE OPERATION OF WATER INTAKES
Authors:   South-Russian State Polytechnic University (NPI) named after M. I. Platov, Khetsuriani E.D. , Garbuz A. Yu. ,   Russian Scientific Research Institute of Land Improvement Problems, Khetsuriani T. E. ,   South-Russian State Polytechnic University (NPI) named after M. I. Platov
Published: November 2021

Purpose: to consider a classification list of heuristic methods allowing solving various design problems in relation to hydraulic facilities located on reclamation systems, taking into account the conditions of the functional operation of soft floating structures as water intake structures. Materials and methods. Efficient use of water resources includes an ecosystem approach, which allows considering water body together with the catchment area, the implemented activities for water discharge (Q, m³/s) with the provision of environmental safety in zones of influence of water intake as a single system. The ecosystem approach to the water bodies under consideration (rivers, reservoirs, etc.) should provide for a set of design and structural measures in water technological complex to ensure environmental safety in the zones of its influence. Results and discussion. Ensuring the fulfillment of these two conditions implies the solution of a number of basic tasks to improve the existing constructive and technological units and to create new ones using modern high-strength synthetic fabric materials of national production. The selection of the required calculated volumes of supplied water resources from the object is from 1 to 100 m³/s and more, which cannot but affect its ecological component, while preserving biological resources and the fish species composition should be implied. Conclusions. In formation of constructive solutions to ensure environmental safety in the zones of influence of water technological complex, one of the most promising directions is the methodological basis for the synthesis of soft floating structures, which ensure the preservation of biological resources in a water body, protection from bottom and suspended sediments, as well as fulfillment of environmental safety requirements.
THE PROLETARSKIY RESERVOIR OPERATION AND USAGE
Authors:   Russian Scientific Research Institute of Land Improvement Problems, Kosichenko Yu. M. , Talalaeva V. F. ,   Russian Scientific Research Institute of Land Improvement Problems
Published: November 2021

Purpose: the studies of the Proletarskiy reservoir is to use the Novo-Manych dam in regulating the operation of the western and eastern sections with a water regulating structure between them. Materials and methods: the issues on use and regulation of water resources of the Proletarsk reservoir are considered, including the Novo-Manych dam, which divides the reservoir into the western and eastern sections. Results. The western section of the Proletarskiy reservoir is located between the Proletarskiy hydroelectric complex and the Novo-Manych dam and is a stretch of about 20 km. Under normal operating conditions, water flows from the western section to the eastern one through the water regulating structure in the Novo-Manych dam. At the same time, the main amount of water enters the western section along the river Egorlyk, it is discharged through the drain of the Proletarskiy hydroelectric dam into the Veselovskoye reservoir. The eastern section of the Proletarskiy reservoir is limited by the Novo-Manych dam on the western side and a blind dam on the eastern side. According to the initial project, the water resources of the Proletarskiy reservoir were used for shipping, irrigation, fisheries, and hydropower. The actual use of the reservoir's water resources for navigation is practically absent, irrigation is not performed, the fishery has lost its importance, and the hydropower industry has been out of service. Only recreation is used: the sanatorium “Manych”, about 30 hunting farms, the “Rostovsky” and “Chernye Zemli” reserves, the natural monument “Primanychskaya steppe”. The network of reservoirs and Manych-Gudilo lake is a wetland of international importance as a habitat for waterfowl. Conclusions. The issues of the use and regulation of water resources of the Proletarskiy reservoir and the Novo-Manych dam, dividing the reservoir into the western and eastern sections are considered.
Anania Sanahnetsi. On the Council of Chalcedon
Authors: Рамазян Георгий
Published: November 2021

В настоящей статье вниманию читателя предлагается перевод малоизвестного древнеармянского текста «О Халкидонском Соборе», который является одной из 15¬и глав (или слов) большого вероучительного произведения автора XI в. Анании Санахнеци - «Слова возражения против диофизитов». Данное произведение является одним из важнейших источников армяно-византийской богословской полемики XI в., его основная тема - защита главных вероучительных особенностей Армянской Церкви и попытка убедить своего православного оппонента в ненужности и непопулярности учения Халкидонского Собора.

In this article is presented a translation of a little-known text in Classical Armenian «On the Council of Chalcedon», which is one of 15 chapters of a large doctrinal work of Anania Sanahnetsi, an author of the 11th century, «Words of objection against the Diphysites». This work is one of the most important sources of the Armenian-Byzantine theological polemics of the 11 th century, its main theme is the defense of the main doctrinal features of the Armenian Church and an attempt to convince its Orthodox opponent of the uselessness and unpopularity of the teachings of the Council of Chalcedon.
Arnobius the Younger and His Works
Authors: Трофимов Пётр Сергеевич
Published: November 2021

Статья посвящена Арнобию Младшему - латиноязычному церковному писателю V в. Приводится краткий обзор основных проблем реконструкции биографии Арнобия (вопросов о его происхождении, принадлежности к клиру, знании им греческого языка и участии в переводе посланий свт. Кирилла Александрийского на латинский язык). Даётся краткое описание всех его сохранившихся произведений и приписываемого сочинения с указанием изданий, основных сведений о времени и цели написания, главных идеях, особенностях богословских положений или экзегетических методов произведения. Арнобий Младший характеризуется как незаслуженно забытый выдающийся полемист и незаурядный экзегет, одно из творений которого, «Диспут с Серапионом», ярко раскрывает христологическое учение Церкви и достойно считаться частью православного Предания. Тем не менее, автор статьи разделяет взгляд новейших исследователей о принадлежности антиавгустиновского трактата «Praedestinatus» Арнобию и об осуждении последнего Римской церковью за «полупелагианские» взгляды.

The article is dedicated to Arnobius the Younger, a Latin writer of the 5th century. Is given a brief overview of the main problems of reconstruction of the biography of Arnobius (questions about his origin, belonging to the clergy, his knowledge of the Greek language and participation in the translation of the epistles of St. Cyril of Alexandria into Latin). Briefly describe all his surviving works and the attributed work is given, indicating the editions, basic information about the time and purpose of writing, the main ideas, features of theological provisions or exegetical methods of the work. Arnobius the Younger is characterized as an undeservedly forgotten outstanding polemicist and extraordinary exegete, one of whose work, «Dispute with Serapion», clearly reveals the Christological teaching of the Church and is worthy of being considered part of Orthodox Tradition. Nevertheless, the author of the article shares the view of the latest researchers about the belonging to Arnobius of the anti-Augustinian treatise «Praedestinatus» and about his condemnation by the Roman Church for «semi-Pelagian» views.
Diversity & Inclusion nachhaltig in Unternehmen und Organisationen verankern: Faktoren einer offenen und inklusiven Unternehmenskultur für homosexuelle Mitarbeitende
Authors: Gurtner Andrea
Published: November 2021

Die Vielfalt der Belegschaft und insbesondere die Dimension sexuelle Orientierung und Geschlechtsidentität gilt als Katalysator innerhalb eines ganzheitlichen Diversity & Inclusion Managements. Diese Studie untersucht, welche Bedeutung homosexuelle Mitarbeitende in der Schweiz einer offenen und inklusiven Unternehmenskultur beimessen. Befragt wurden 32 homosexuelle Personen zu ihren Erfahrungen am Arbeitsplatz. Als zentraler Faktor wurde die Haltung der unmittelbaren Vorgesetzten identifiziert. Inklusive Massnahmen auf Organisationsebene waren hingegen oft nicht vorhanden und wurden nicht erwartet. Wo sie vorhanden waren, wurden sie allerdings geschätzt. Der Artikel formuliert Massnahmen zur Inklusion von homosexuellen Mitarbeitenden im Rahmen eines nachhaltigen D&I Managements.
ADAPTIVE ALGORITHM FOR DETERMINING THE PARAMETERS OF AN INACCESSIBLE POINT OF AN OBJECT
Authors: Brailov Aleksandr , Panchenko Vitaliy
Published: November 2021

In the present research the optimizing approach to the determination of the parameters of an inaccessible point of an object is developed. The common issues are revealed and essential steps of their resolution are identified.

The essence of the problem is an objective contradiction between a requirement for the location of points A and B of the centers of the sighting tubes of optical devices in the same horizontal plane P1 and the lack of a real possibility to perform such to achieve this an identical one-level arrangement without error.

The aim of the study is to develop strategies for determining the position of an inaccessible point of an object in the minimum domain between intersecting sighting rays as well as an adaptive algorithm for determining the values of the parameters of an inaccessible point under the given absolute and relative errors.

To achieve this aim, the following problems are formulated and solved in the paper: 1. Develop strategies for determining the position of the inaccessible point of the object in the minimum domain between the intersecting sighting rays. 2. Develop an adaptive algorithm for determining the values of the parameters of an inaccessible point based on the specified absolute and relative errors.

In the proposed optimizing approach, the three-dimensional geometrical model with crossed directional rays for the determination of coordinates of the inaccessible point of an object is developed. It is discussed that points С and C', coordinated of which to be determined, locates in domain [CDM, CEM], [C'D'M, C'E'M] of the minimum distance ρmin between crossed directional rays.

The optimizing problem of the determination of coordinates of an inaccessible point of an object in space is reduced to a problem of the determination of the minimum distance between two crossed directional rays.

It’s known from the theory of function of multiple variables that function ρ = f (tC'D', tC'E') reaches its extremum ρmin when its partial derivatives by each variable are equal to zero.

Three strategies for selecting the position of the inaccessible point C (xC, yC, zC) in the found minimum region [CDM, CEM] are proposed. The required point C' (xC', yC', zC') can be located, for example, in the middle of the minimum segment [C'D'M, C'E'M].

The essence of the adaptive algorithm is in optimizing the variation of the initial values of data α, α', β, γ, γ', AB, at which the absolute and relative errors of the coordinates of the inaccessible point satisfy the error values set by the customer (0.0001-1.2%)

The proposed approach is verified using real experimental data.
SCREW DESCENT, ANALYTICAL DESCRIPTION OF WHICH INCLUDES THE EQUATION OF PARTICLE MOVEMENT ON AN INCLINED PLANE
Authors: Volina Tatiana
Published: November 2021

To study the modes of particle movement depending on the constructive parameters of the surface, it is important to have analytical dependencies of this movement. An analytical description of the movement of a load on the example of a material particle on the surface of a gravitational descent formed by a screw conoid and a coaxial vertical limiting cylinder was developed in the article. It makes it possible to find the constructive parameters of the descent, which will provide the required speed of the transportation. If the surface of the confining cylinder is absolutely smooth, then the movement of the particle along such a descent will be uniformly accelerated or equally slowed down depending on the value of the angle of inclination of the plane, that is, similar to movement along an inclined plane. If the angle of inclination of the plane is equal to the angle of friction, then the particle will move with a constant angular velocity of rotation, then one can find the linear velocity, which will also be constant. The value of this speed will be equal to the initial one. If the angle of inclination of the plane is equal to the angle of friction, but the coefficient of friction is not equal to zero, then the particle will be decelerated due to the action of the friction force of the particle on the surface of the cylinder. This is the difference from descent along an inclined plane, along which the particle in this case will move at a constant speed. In the general case, when the angle of ascent of the helix is ​​greater than the angle of friction, the driving force and the force of friction on the surface of the conoid and on the surface of the cylinder are balanced with each other and the angular velocity of rotation of the particle becomes constant. Consequently, it is possible to provide the required speed of transportation of the material at various ratios of the structural parameters of the surface with known coefficients of friction. To reduce the overall dimensions of the screw descent, it is necessary to reduce the radius of the limiting cylinder; however, with this limitation, the weight of loads should be taken into account.
The Production and characterization of Polyclonal Antibodies Against Interferon Alpha in Mice
Authors: Fatima Mehreen , Khalid Fatima , Quraishi Azra
Published: November 2021

The polyclonal antibodies are used extensively for research purposes in many areas of biology, such as immunoprecipitation, histochemistry, enzyme linked immunosorbent assays (ELISA), diagnosis of disease and western blots. Typically, an animal’s immune system will generate a large group of antibodies that recognize several epitopes of a particular antigen. Interferon alpha plays an important role in immune response activation and therefore is of interest in studies related to autoimmune diseases. In this paper the production of antibodies against interferon was studied in order to quantify interferon production to analyze interferon levels in autoimmune disorders in the future. For the antibody production, one month old laboratory grade mice were injected with interferon alpha in combination with a Freund’s complete adjuvant for a course of five weeks after which the antibodies were obtained in mouse serum. Confirmation of the production of anti-interferon alpha antibodies was carried out by the Elisa, immune dot blot and western blot analysis. An interferon alpha of approximately 20.5-21.5 KDa was detected in immunedot blot test.  These antibodies may be produced in these mouse models commercially and could be used in future for treatment of autoimmune diseases by managing the interferon levels in the patients.

Copyright(c) The Authors
Formation of sets of independent components of a multidimensional random variable based on a nonparametric pattern recognition algorithm
Authors: Lapko Aleksandr V. , Lapko Vasiliy A. , Bakhtina Anna V.
Published: November 2021

The possibility of circumventing the problem of decomposition of the range of values of random variables when testing various hypotheses is considered. A brief review of the literature on this problem is given. A method for forming sets of independent components of a multidimensional random variable is proposed, based on hypotheses testing about the independence of paired combinations of components of a multidimensional random variable. The method uses a two-dimensional non-parametric algorithm for pattern recognition of the kernel type, corresponding to the criterion of maximum likelihood. In contrast to the traditional method based on the application of the Pearson criterion, the proposed approach avoids the problem of decomposing the range of values of random variables into multidimensional intervals. The results of computational experiments performed according to the method of forming sets of independent random variables are presented. Using the information obtained, an information graph is constructed, the vertices of which correspond to the components of a multidimensional random variable, and the edges determine their independence. Then the vertices of the complete subgraphs correspond to groups of independent components of a random variable. The obtained results form the basis for the synthesis of a multi-level nonparametric large volume data processing system, each level of which corresponds to a specific set of independent random variables.
La protección de los Derechos Sexuales y Reproductivos en tiempos de Covid-19
Authors: López Hernán , Pérez Alejandra
Published: November 2021

En Chile actualmente, no existe un reconocimiento normativo intencionado hacia los derechos sexuales y reproductivos dentro de la especialidad que merecen. Sin duda, en el contexto de pandemia y cuarentenas obligatorias que actualmente enfrenta la humanidad a consecuencia del virus SARS-CoV2 que da origen a la enfermedad Covid-19, se presenta un complejo escenario en la protección de los derechos fundamentales, encontrándose mayormente expuestos, amenazados o afectados en su ejercicio.
Pengaruh Motivasi Kerja Dan Lingkungan Kerja Terhadap Kinerja Karyawan Pada PT Sriwijaya Dinamika Perkasa Di Surabaya
Authors: Mulyadi Mulyadi , Purnomo Niko , Sutrisno Sutrisno , Komarudin Komarudin , Suryani N Lilis
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh motivasi kerja dan lingkungan kerja terhadap kinerja karyawan pada PT. Sriwijaya Dinamika Perkasa di Surabaya. Metode yang digunakan adalah explanatory research dengan teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini motivasi kerja berpengaruh signifikan terhadap kinerja karyawan sebesar 46,7%, uji hipotesis diperoleh t hitung > t tabel atau (7,190 > 2,001). Lingkungan kerja berpengaruh signifikan terhadap kinerja karyawan sebesar 48,8%, uji  hipotesis diperoleh t hitung > t tabel atau (7,492 > 2,001). Motivasi kerja dan lingkungan kerja secara simultan berpengaruh signifikan terhadap kinerja karyawan dengan persamaan regresi Y = 7,031 + 0,378X1 + 0,466X2 dan kontribusi pengaruh sebesar 65,2%, uji hipotesis diperoleh F hitung > F tabel atau (54,241 > 2,760).
Pengaruh Pelayanan Purna Jual Terhadap Loyalitas Konsumen Pada Dealer Piagio Vespa Di Kota Tangerang Selatan
Authors: Ani Anri , Hanifah Fadhilah , Christina Vita Stefanya , Sewaka Sewaka
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan purna jual terhadap loyalitas konsumen pada Dealer Piagio Vespa di Kota Tangerang Selatan. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 96 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel pelayanan purna jual diperoleh nilai rata-rata skor sebesar 3,414 dengan kriteria baik. Variabel loyalitas konsumen diperoleh nilai rata-rata skor sebesar 3,830 dengan kriteria baik. Pelayanan purna jual berpengaruh positif dan signifikan terhadap loyalitas konsumen dengan nilai persamaan regresi Y = 9,636 + 0,840X, dan nilai koefisien korelasi 0,771 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 59,4%. Uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
Pengaruh Store Atmosphere Terhadap Keputusan Pembelian Pada Starbucks Di Jakarta
Authors: Hidayat Haris Suganda , Nurlina Nurlina , Kharismawaty Rahayu , Wijaya Safta , Maddinsyah Ali
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh Store Atmosphere terhadap keputusan pembelian pada Starbucks di Jakarta. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 102 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel Store Atmosphere diperoleh nilai rata-rata skor sebesar 3,411 dengan kriteria baik. Variabel keputusan pembelian diperoleh nilai rata-rata skor sebesar 3,837 dengan kriteria baik. Store Atmosphere berpengaruh positif dan signifikan terhadap keputusan pembelian dengan nilai persamaan regresi Y = 9,297 + 0,852X, dan nilai koefisien korelasi 0,777 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 60,4%. Uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
Pengaruh Kualitas Pelayanan Terhadap Keputusan Pembelian Krispy Kreme Di Supermall Ciledug Tangerang
Authors: Lubis Imam Sofyan , Ardiansah Riyan , Jaya Syukur , Kasmad Kasmad
Published: November 2021

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas pelayanan terhadap keputusan pembelian Krispy Kreme di Supermall Ciledug Tangerang. Metode yang digunakan adalah explanatory research dengan sampel sebanyak 96 responden. Teknik analisis menggunakan analisis statistik dengan pengujian regresi, korelasi, determinasi dan uji hipotesis. Hasil penelitian ini variabel kualitas pelayanan diperoleh nilai rata-rata skor sebesar 3,408 dengan kriteria baik. Variabel keputusan pembelian diperoleh nilai rata-rata skor sebesar 3,838 dengan kriteria baik. Kualitas pelayanan berpengaruh positif dan signifikan terhadap keputusan pembelian dengan nilai persamaan regresi Y = 9,285 + 0,853X, dan nilai koefisien korelasi 0,776 atau memiliki tingkat hubungan yang kuat dengan nilai determinasi 60,2%. Uji  hipotesis diperoleh signifikansi 0,000 < 0,05.
Analisis Performa Modul Surya Cell Terhadap Penggunaan Reflektor Alumunium Foil
Authors: Setiyono Joko , Pramadi Riyan , Sulanjari Sulanjari , Astuti Fifit
Published: November 2021

Modul sel surya merupakan perangkat yang dapat mengubah sinar matahari menjadi energi listrik. Sinar matahari merupakan sumber energi terbarukan yang dapat digunakan sebagai pembangkit listrik baru. Namun dalam pengerjaannya sesuai dengan permintaan penambahan modul solar cell tertentu agar daya keluaran yang dihasilkan dapat optimal. Penelitian ini bertujuan untuk mengetahui pengaruh penambahan reflektor terhadap intensiatas, daya masukan dan daya keluaran modul sel surya yang dihasilkan, serta mengetahui efisiensi dari variasi kemiringan sudut reflektor. Modul solar cell yang digunakan adalah 1 unit dengan kapasitas 50 Wp. Pengujian dilakukan pada pukul 10.00-14.00, dengan menggnakan 2 dan 4 reflektor. Penelitian ini menggunakan reflektor dengan kemiringan 45º, 55, dan 65º dengan tinggi reflektor 250mm pada setiap sisinya. Daya keluaran modul sel surya menggunakan reflektor tertinggi adalah 65.737 Watt dengan sudut kemiringan 65°.
Standar Pengukuran Debit dan Tekanan Air Pada Mesin Uji Pompa Sentrifugal Dengan Menggunakan Inverter
Authors: Basuki Budhy
Published: November 2021

Standar untuk mesin uji pompa sentrifugal telah dibuat dengan model seri dan paralel. Pengukuran yang dilakukan adalah tekanan dan debit air yang dihasilkan oleh sebuah pompa. Putaran pompa dapat divariasikan  dengan sebuah inverter dan inverter dapat dihubungkan dengan dua buah pompa. Hasil pengujian Frekwensi 50 Hz  pada pengujian pompa seri arus pompa-1 dan pompa-2 masing 1,75 amper dan 1,8 amper dan pengujian pompa paralel 50 Hz  pompa 1 dan pompa 2 didapat 1,8 dan 1,81 amper.
Maceral Association in Coal-bearing Formation of Mae Than Coal Mine in Lampang, Thailand - Implication for Depositional Environment
Authors:   Faculty of Environment and Resource Studies, Mahidol University, Nakhon Pathom 73170, Thailand, Sattraburut Thunyapat , Ratanasthien Benjavun ,   Department of Geological Sciences, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand
Published: November 2021

The Mae Than Basin in Lampang Province contains low-ranked coal reserves of northern Thailand. Coal seams and ball clays were mined in the southern part of the basin. This study focuses on the coal petrography of coal samples collected from the upper coal seam in the Mae Than Coal Mine. Both the organic and inorganic constituents provide information on the nature and characteristics of the coal, reflecting the physical and chemical behaviors of coal. Petrological analysis reveals that the Mae Than coals contain more huminite than liptinite macerals, while inertinite is negligible. Huminite occurs mainly in the form of texto-ulminite, textinite, densinite, and gelinite. Liptinite consists of sporinite, cutinite, resinite, suberinite, liptodetrinite, and terpenite. The morphology of cutinite, sporinite, and the presence of terpenite indicate that the peat-forming vegetation may consist of conifers. In addition to the macerals, the coal samples contain a small to moderate amount of mineral matter. Silica and clay minerals are the main minerals found in the cavities and between the cracks of the coals. The assemblage of macerals and mineral matter indicates that the Mae Than coals were formed mainly from common peat-forming vegetation, possibly conifers, in a freshwater forest swamp or mire in a warm temperate climate. In addition, the high degree of preservation of the macerals indicates a high water table and suggests rheotrophic, anoxic, limnotelmatic to telmatic conditions during deposition.
Підготовка наукових кадрів вищої кваліфікації зі спортивної медицини, лікувальної фізкультури та фізичної реабілітації в Україні
Authors: Клапчук В. В.
Published: November 2021

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Реалізація функціонального потенціалу й особливості прояву спеціальної працездатності кваліфікованих спортсменів у циклічних видах спорту
Authors: Е. Н. Лысенко  , Н. П. Еременко  , В. В. Соколов
Published: November 2021

Мета. Визначити значення рівня загального (базового) функціонального потенціалу організму кваліфікованих веслувальників-байдарочників для подальшої його ефективної реалізації в умовах виконання спеціальних тренувальних і змагальних навантажень. Методи. Визначалася фізична працездатність спортсменів і реакція дихальної і серцево-судинної систем у реальному масштабі часу «breath-by-breath» (ергоспірометричний комплекс «Oxycon Pro», VIASYS Health) на максимальні і стандартні фізичні навантаження (тредміл LЕ-200 CЕ, веслувальний ергометр «Paddlelite»). Результати. Для спортсменів-лідерів на дистанції 1000 м у веслуванні на байдарках характерний високий рівень фізичної працездатності і більш високий рівень реалізації аеробних можливостей організму в умовах виконання фізичної роботи різного характеру енергозабезпечення та проходження контрольної дистанції 1000 м. Спортсменівлідерів на дистанції 200 м відрізняв знижений рівень фізичної працездатності, який поєднувався з незначним рівнем аеробних можливостей і більшою часткою анаеробних гліколітичних процесів в енергозабезпеченні. Зі збільшенням максимальної потужності тестувальної роботи, досягнутої спортсменами-веслувальниками в лабораторних умовах, відзначається збільшення швидкості проходження контрольної дистанції 1000 м, що свідчить про збільшення рівня спеціальної працездатності і рівня тренованості спортсменів. Висновки. За результатами виконання тестових навантажень у лабораторних умовах, що дозволяють визначити аеробні та анаеробні можливості організму спортсменів, можна прогнозувати рівень спеціальної працездатності кваліфікованих спортсменів-веслувальників.
Морфофункціональна характеристика організму спортсменок високої кваліфікації, які спеціалізуються у дзюдо
Authors: М. А. Чистякова
Published: November 2021

Мета. Дослідити морфофункціональний стан спортсменок високої кваліфікації, які спеціалізуються у дзюдо. Методи. Анкетування; дослідження морфофункціонального стану організму; педагогічне тестування (для оцінки змішаної аеробно-анаеробної працездатності – тест JMG, для оцінки анаеробної працездатності – тест SFJT). Результати. Порушення циклічності відзначено у 39,5 % спортсменок. Вищі значення маси тіла спостерігали в передменструальну фазу циклу. Прояв спеціальної роботоздатності має циклічний характер.  Так, найкращі показники функціональних і психофізіологічних можливостей організму спортсменок відмічено в постменструальну і особливо постовуляторну фази. В менструальну, овуляторну і передменструальну фази показники спеціальної роботоздатності знижуються.  Висновки. Встановлено, що показники спеціальної роботоздатності, швидкісні і координаційні можливості спортсменок високої кваліфікації, які спеціалізуються у дзюдо, змінювалися на фоні циклічних гормональних змін у динаміці менструального циклу.
Ефективність впливу дієтичної добавки «Лептин Менеджер» на зниження маси тіла у жінок з різними генотипами за геном рецептора до лептину, які займаються силовим фітнесом
Authors: Дроздовська С. Б. , Палладіна О. Л. , Юрьєв С. Д. , Поліщук А. О. , Гончаров С. В. , Досенко В. Є.
Published: November 2021

Мета. Встановити ефективність поєднаної дії дієтичної добавки Leptin ManagerTM та програми силового фітнесу на зниження маси тіла жінок І та ІІ періоду зрілого віку з різними генотипами. Методи. У дослідженні, яке тривало 3 міс., взяли участь 62 жінки ІІ періоду зрілого віку з надлишковою масою тіла (ІМТ ≥ 25), з них до експериментальної групи увійшла 21 жінка, яка брала участь у тренувальній програмі з силового фітнесу на фоні одночасного прийому препарату «Лептин Менеджер» (Xymogen, USA). Контрольну групу склали 17 жінок, котрі займалися силовим фітнесом і не приймали препарат, та 24 жінки, які не займалися фітнесом. Тренування було побудовано за системою Crossfit, функціонального тренінгу та включало роботу на тренажерах (блочні та важельні пристрої) за системою Full-body у кожному тренуванні. Q223R поліморфізм гена рецептора до лептину (LEPR) визначали методом полімеразної ланцюгової реакції (ПЛР) у реальному часі. Визначення лептину проводили ензимним імунозв’язуючим імуносорбентним методом, визначення композиційного складу тіла – методом біоімпедансометрії за допомогою приладу «Tanita». Результати. Рівень лептину у жінок з надмірною масою тіла характеризується широким діапазоном, що перевищує норму у бік низьких, так і високих концентрацій: у 4 % жінок рівень цього гормону нижчий від норми, а у 36 % – вищий від норми. Показник лептину у жінок–носіїв Q-алеля вдвічі вищий, ніж у жінок– носіїв R/R-генотипу (р = 0,045). Встановлено тісний лінійний зв’язок між рівнем лептину і такими показниками, як індекс маси тіла (r = 0,7) і вміст жирової тканини (r = 0,73); середнього ступеня зв’язок між рівнем лептину і масою тіла (r = 0,65). Поєднаний вплив тренувальної програми силового фітнесу та вживання препарату «Лептин Менеджер» призводить до більш значних змін антропометричних показників, композиційного складу тіла жінок з надмірною масою тіла порівняно з контрольною групою. Найбільш виражені зміни у композиційному складі тіла відбулися у жінок з R/R-генотипом гена LEPR. Вживання препарату «Лептин Менеджер» призводить до зменшення рівня лептину: в експериментальній групі – на 33,4 % (р < 0,05), у контрольній – на 6,1 %. Висновки. Q223R поліморфізм гена LEPR може слугувати молекулярно-генетичним маркером лептинової резистентності. Q-алель Q223R поліморфізму гена LEPR сприяє розвитку ожиріння. R-алель та R/R-генотип гена LEPR – зниженню рівня цього гормону після фізичних навантажень. Вживання препарату «Лептин Менеджер» на фоні фізичних навантажень призводить до вірогідного зменшення рівня лептину порівняно з контрольною групою.