bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydroxyethyl Starch Improves the Prognosis of Rats with Traumatic Shock via Activation of the ERK Signaling Pathway in Lymphocytes
Authors: Liu Yun , Lu Jian , Dong Caifu , Zhu Limin , Zhou Li , Zhu Kai
Published: February 2022

Objective. Severe traumatic shock is one of the leading causes of death in young adults. A large number of studies have shown that effective volumetry resuscitation on the basis of controlled injury can not only increase the success rate of early resuscitation but also reduce systemic inflammatory response and improve the cure rate of severe traumatic shock. The study explored the effects of hydroxyethyl starch (HES) on the survival rate, lymphocyte function and proliferation of rats with traumatic shock, and the potential mechanisms. Methods. Traumatic shock was constructed in rats as experimental model, and liquid resuscitation was performed using HES and lactated Ringer’s (LR). 24-h mortality was recorded, and lymphocytes were isolated. The expressions of signaling pathway factors was detected by qPCR and Western blot. ELISA was performed to determine the expression of interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in cell supernatant. Results. HES for fluid resuscitation augmented the survival of traumatic shock rats, upregulated the expressions of MEK and ERK1/2, and downregulated the expressions of IL-6 and TNF-α. However, inhibition of ERK signaling pathway reversed the effect of HES on the immune improvement and the 24-h survival rate of the traumatic shock rats (

P
<
0.05

). Conclusion. HES could exert the anti-inflammatory effects on lymphocytes by mediating the phosphorylation of proteins of the ERK signaling pathway. HSE demonstrated a high efficacy in effectively treating traumatic shock, thus could be used in clinical practice.
A Decentralized Electronic Reporting Scheme with Privacy Protection Based on Proxy Signature and Blockchain
Authors: Zou Huiying , Liu Xiaofan , Ren Wei , Zhu Tianqing
Published: February 2022

The electronic reporting system can alleviate the problems in terms of efficiency, content confidentiality, and reporter privacy imposed in the traditional reporting system. Relying on anonymity, the privacy of reporters can be protected, but the authentication of reporters with fake names should also be maintained. If authenticated anonymity is guaranteed, the reporters may still conduct misbehaviors such as submitting fake reports after the authentication. To address the above dilemma, we propose to apply a proxy signature to achieve authenticated anonymity and employ blockchain to maintain anonymity yet guarantee traceability for reporters’ misbehaviors. We also propose a new proxy signature scheme in this paper by module lattice for postquantum security. The extensive analysis justified our proposed scheme is secure and manageable.
Inhibiting Autophagy Pathway of PI3K/AKT/mTOR Promotes Apoptosis in SK-N-SH Cell Model of Alzheimer’s Disease
Authors: Pang Yu , Lin Wennan , Zhan Lan , Zhang Jiawen , Zhang Shicun , Jin Hongwei , Zhang He , Wang Xiaoli , Li Xiaoming
Published: February 2022

Alzheimer’s disease is the most common dementia disease characterized by chronic progressive neurodegeneration. The incidence of Alzheimer’s disease is on the rise as the population ages at an accelerating pace. According to epidemiological data, by 2050, the number of Alzheimer’s patients in the United States will be three times higher than that in 2010, and a similar trend is occurring in China. To explore the effect and mechanism of let-7b by detecting the expression level of let-7b in Alzheimer’s disease, fifty patients with Alzheimer’s disease and thirty healthy controls were selected. The expression levels of let-7 families (let-7a, let-7b, let-7c, let-7d, let-7e, let-7f, let-7g, and let-7i) were detected by qPCR. Human neuroblastoma cell SK-N-SH were divided into control group (untreated), model group (treated with Aβ1-40), Aβ1-40+let-7b mimic group (treated with Aβ1-40 and transfected with let-7b mimic), and Aβ1-40+miR-NC group (treated with aβ1-40 and transfected with miR-NC). let-7b expression and cell survival rate were detected by qPCR and CCK-8, and the levels of caspase 3, LC3, beclin-1, PI3K, p-AKT, and p-mTOR were detected by Western blot. let-7b was significantly different between the case group and the control group (

p

 < 0.001). CCK-8 showed a significant decrease in cell viability in Aβ1-40 treatment group compared with that in the control group (

p

 < 0.01). Overexpression of let-7b significantly reduced the survival rate of the cells, and the expression of LC3II/LC3I and beclin-1 in the cells was significantly reduced by aβ1-40 treatment (

p

 < 0.001). let-7b overexpression also inhibited autophagy via reducing the level of LC3II/LC3I and beclin-1 (

p

 < 0.001). Aβ1-40 treatment and let-7b overexpression promoted apoptosis by increasing the expression of cleavage caspase 3. Western blot indicated that Aβ1-40 treatment and let-7b overexpression could increase the expression of PI3K, p-AKT, and p-mTOR. let-7b overexpression could inhibit autophagy and promote apoptosis in Alzheimer’s cells by promoting PI3K/AKT/mTOR signaling pathway. PI3K/AKT/mTOR signaling pathway is involved in the imbalance between autophagy and apoptosis.
Graded Control Technology of Oil Stability and Water Control in Fracture-Pore Carbonate Reservoirs
Authors: Zhao Wenqi , Zhao Lun , Li Junjian , Hou Jue , Guo Xuejing
Published: February 2022

In view of the prominent problems of extremely strong heterogeneity, fracture development of different scales, and serious rapid water channelling in the process of water injection development in fracture-pore carbonate reservoirs, a comprehensive treatment method of oil stabilizing and water controlling is proposed, which includes fracture classification control, combination of adjustment and plugging, and wettability change. Based on the static and dynamic test data, the characteristics of reservoir fracture development and fracture scales are described in detail. By means of reservoir engineering and numerical simulation, the water flooding rule under different grade fracture reservoir conditions is studied, the influence of different levels of fractures on water injection development is evaluated, and the improvement effect of different control methods on water drive sweep is demonstrated. Research shows that a large amount of remaining oil trapped in pores is affected by fracture water channelling, which makes it difficult to use effectively. The water flooding sweep characteristics of reservoirs with different scales of fractures are quite different, and large-scale fractures are the main reason for ineffective water injection. The hierarchical control techniques of plugging large-scale fractures, intervening and adjusting small- and medium-scale fractures, and changing the wettability of microscale pore media can significantly extend the water flooding spread range and effectively improve oil well production. The research results have been applied in the field and achieved good results. This technology can provide theoretical guidance and a technical basis for the comprehensive treatment of oil stabilization and water control in fractured-porous carbonate oil and gas reservoirs.
Analysis of the Nursing Effect of Respiratory Critical Illness Based on Refined Nursing Management
Authors: Shi Wenjuan , Shen Ying , Zhang Beilei , Jin Mengni , Qian Jiale , Jin Xiaoliang
Published: February 2022

In order to improve the nursing effect of respiratory critical illness, this paper combines the refined nursing method to explore the nursing plan of respiratory critical illness. Moreover, this paper uses the variable control method to explore the effects of nursing management, combines the hospital patient samples to conduct a controlled trial analysis, and conducts sample grouping according to the random grouping method. The patients in the control group are managed by traditional nursing management methods, the patients in the test group are managed by refined nursing management methods, and other conditions are basically the same. In addition, the experiment process variable control is carried out according to the mathematical statistics method, and the reasonable statistics and data processing are carried out. Through the comparison method, we can see that the refined management method proposed in this paper has a good effect in the nursing of respiratory critical illness.
Refined Multiscale Entropy Analysis of Wrist Pulse for Gender Difference in Traditional Chinese Medicine among Young Individuals
Authors: Xu Huaxing , Wang Qia , Mao Xiaobo , Shang Zhigang , Zhao Yuping , Huang Luqi
Published: February 2022

Pulse signal analysis plays an important role in promoting the objectification of traditional Chinese medicine (TCM). Like electrocardiogram (ECG) signals, wrist pulse signals are mainly caused by cardiac activities and are valuable in analyzing cardiac diseases. A large number of studies have reported ECG signals can distinguish gender characteristics of normal healthy subjects using entropy complexity measures, consistently showing more complexity in females than males. No research up to date, however, has been found on examining gender differences with wrist pulse signals of healthy subjects on entropy complexity measures. This paper is aimed to fill in the research gap, which could, in turn, provide a deeper insight into the pulse signal and might identify potential differences between ECG signals and pulse signals. In particular, several complementary entropy measures with corresponding refined composite multiscale versions are established to perform the analysis for the filtered TCM pulse signals. Experimental results reveal that regardless of entropy measures used, there is no statistically significant gender difference in terms of entropy complexity, indicating that the pulse signal holds less gender characteristics than the ECG signal. In view of these findings, wrist pulse signals could be likely to provide different pieces of information to ECG signals. The present study is the first to quantitatively evaluate gender differences in healthy pulse signals with measures of entropy complexity and more importantly; we expect this study could make contribution to the ongoing pulse intelligent diagnosis and objective analysis, further facilitating the modernization of TCM pulse diagnosis.
Psychological Health Intervention of Rural Art and Cultural Communication of Dihuagu in Nanxian County under the Background of Network
Authors: Liu Jie
Published: February 2022

Background. With the development of the Internet, people are facing greater pressure. People in modern society are facing the threat of mental illness. For people with poor mental health, it is necessary to take an appropriate psychological intervention. Nanxian dihuagu is not only a form of folk dance but also a collection of local people’s artistic wisdom. Now, Nanxian dihuagu artists use network media to record it. Objective. Introduce the cultural connotation and value function of dihuagu dance in Mingnan county. Methods. In this paper, literature and field survey methods, according to the logical analysis method of dance point of view, a detailed analysis of multiculture, from the perspective of comprehensive academic research methods, explore the value and cultural significance of dance. Results. The Internet has promoted the exchange of local art and culture, and the effective communication has been formed under the promotion of network media. But the Internet age has also led to some problems, and psychological intervention can effectively improve the psychological problems caused by the network. Conclusions. In this paper, the research process is not limited to the dance itself, at the same time, starting from the local folk customs, focusing on the analysis of the significance and value function of dance culture, which provides a reference for the development and optimization of folk customs. And through the analysis of Nanxian dihuagu, we can know more about the national culture and promote the development of Chinese national culture.
An Improved Security Authentication Protocol for Lightweight RFID Based on ECC
Authors: Wei Guo-heng , Qin Yan-lin , Fu Wei
Published: February 2022

The security, privacy, and operation efficiency of radio frequency identification (RFID) must be fully measured in practical use. A few RFID authentication schemes based on elliptic curve cryptography (ECC) have been proposed, but most of them cannot resist the existing attacks. The scheme presented by Qian et al. could not resist impersonation attack according to our security analysis. Then, we propose a novel lightweight RFID authentication scheme, which is proved that it can resist server spoofing attack, tag masquerade attack, and provide other security properties of a RFID authentication scheme. Comparisons of computation and communication cost demonstrate that the proposed scheme is more suitable for the resource-constrained RFID authentication.
Social Network Community‐Discovery Algorithm Based on a Balance Factor
Authors: Liu Lizhao , Shu Xiaomei , Cai Biao
Published: February 2022

Community discovery plays a crucial role in understanding the structure of networks. In recent years, the application of clustering algorithms in the community‐discovery tasks of complex networks has been studied frequently. In this study, we proposed a balance factor of node density and node‐degree centrality for the core‐node selection problem in community discovery. We also proposed a new community‐discovery algorithm based on the balance factor, adaptability, and modularity increment, which is based on the balance factor (BComd). First, the proposed method was able to identify the core nodes in a community. Second, we used node‐degree centrality, node density, and adaptability to detect overlaps between communities and then we removed these overlaps from the network to obtain a subnetwork with a clear community structure. Third, we obtained the preliminary community divisions by clustering the subnetworks, and these preliminary communities were usually the core parts of the communities they belonged to. Finally, each preliminary community was compressed into a new node, and then, the new network was clustered using the Louvain algorithm. The experimental results showed that the algorithm identified the core nodes in communities well, effectively discovered overlaps between communities, and had superior performance in large‐scale networks.
Crucial Genes in Aortic Dissection Identified by Weighted Gene Coexpression Network Analysis
Authors: Zhang Hongliang , Chen Tingting , Zhang Yunyan , Lin Jiangbo , Zhao Wenjun , Shi Yangyang , Lau Huichong , Zhang Yang , Yang Minjun , Xu Cheng , Tang Lijiang , Xu Baohui , Jiang Jianjun , Chen Xiaofeng
Published: February 2022

Background. Aortic dissection (AD) is a lethal vascular disease with high mortality and morbidity. Though AD clinical pathology is well understood, its molecular mechanisms remain unclear. Specifically, gene expression profiling helps illustrate the potential mechanism of aortic dissection in terms of gene regulation and its modification by risk factors. This study was aimed at identifying the genes and molecular mechanisms in aortic dissection through bioinformatics analysis. Method. Nine patients with AD and 10 healthy controls were enrolled. The gene expression in peripheral mononuclear cells was profiled through next-generation RNA sequencing. Analyses including differential expressed gene (DEG) via DEGseq, weighted gene coexpression network (WGCNA), and VisANT were performed to identify crucial genes associated with AD. The Database for Annotation, Visualization, and Integrated Discovery (DAVID) was also utilized to analyze Gene Ontology (GO). Results. DEG analysis revealed that 1,113 genes were associated with AD. Of these, 812 genes were markedly reduced, whereas 301 genes were highly expressed, in AD patients. DEGs were rich in certain categories such as MHC class II receptor activity, MHC class II protein complex, and immune response genes. Gene coexpression networks via WGCNA identified 3 gene hub modules, with one positively and 2 negatively correlated with AD, respectively. Specifically, module 37 was the most strongly positively correlated with AD with a correlation coefficient of 0.72. Within module 37, five hub genes (AGFG1, MCEMP1, IRAK3, KCNE1, and CLEC4D) displayed high connectivity and may have clinical significance in the pathogenesis of AD. Conclusion. Our analysis provides the possible association of specific genes and gene modules for the involvement of the immune system in aortic dissection. AGFG1, MCEMP1, IRAK3, KCNE1, and CLEC4D in module M37 were highly connected and strongly linked with AD, suggesting that these genes may help understand the pathogenesis of aortic dissection.
A Torn ACL Mapping in Knee MRI Images Using Deep Convolution Neural Network with Inception-v3
Authors: Sridhar S. , Amutharaj J. , Valsalan Prajoona , Arthi B. , Ramkumar S. , Mathupriya S. , Rajendran T. , Waji Yosef Asrat
Published: February 2022

The anterior cruciate ligaments (ACL) are the fundamental structures in preserving the common biomechanics of the knees and most frequently damaged knee ligaments. An ACL injury is a tear or sprain of the ACL, one of the fundamental ligaments in the knee. ACL damage most generally happens during sports, for example, soccer, ball, football, and downhill skiing, which include sudden stops or changes in direction, jumping, and landings. Magnetic resonance imaging (MRI) has a major role in the field of diagnosis these days. Specifically, it is effective for diagnosing the cruciate ligaments and any related meniscal tears. The primary objective of this research is to detect the ACL tear from MRI knee images, which can be useful to determine the knee abnormality. In this research, a Deep Convolution Neural Network (DCNN) based Inception-v3 deep transfer learning (DTL) model was proposed for classifying the ACL tear MRI images. Preprocessing, feature extraction, and classification are the main processes performed in this research. The dataset utilized in this work was collected from the MRNet database. A total of 1,370 knee MRI images are used for evaluation. 70% of data (959 images) are used for training and testing, and 30% of data (411 images) are used in this model for performance analysis. The proposed DCNN with the Inception-v3 DTL model is evaluated and compared with existing deep learning models like VGG16, VGG19, Xception, and Inception ResNet-v28. The performance metrics like accuracy, precision, recall, specificity, and F-measure are evaluated to estimate the performance analysis of the model. The model has obtained 99.04% training accuracy and 95.42% testing accuracy in performance analysis.
[Retracted] Design Analysis of Intelligent Enterprise Costing Platform Based on a Virtual Network Mapping Algorithm
Authors: Meng Xiangxia , Zhao Dan , Tian Shuguo
Published: February 2022

Cost management is an important part of enterprise management and is fundamental to the survival and development of enterprises. Cost management is of great significance to promote production and cost‐saving, strengthen cost accounting, improve management, and enhance the overall management level of enterprises. In this paper, different factors affecting mapping are combined with a group intelligence algorithm to study virtual network mapping, which dissects enterprise cost management in a new perspective and analyzes the relationship between enterprises in each supply chain and the association between the processes of each link in the supply chain. The algorithm uses node CPU, node degree, and neighboring bandwidth resources as advisors’ strategies, respectively, and customers consult multiple advisors in the process of constructing mapping solutions, and the advisors give suggestions to customers according to their strategies. CGS‐VNE uses an advisor‐guided search mechanism to ensure the diversity of mapping solutions, which can fully explore the solution space and derive high‐quality enterprise costing solutions through iteration. Whether in evaluating enterprise cost control or enhancing enterprise cost control capability, the value chain theory can be practically applied to clarify the current situation of enterprise cost control under the premise of combining theory and practice and truly achieve the fundamental purpose of helping enterprises to fully implement cost control.
New Insights into Artesunate as a Pleiotropic Regulator of Innate and Adaptive Immune Cells
Authors: Lin Lixian , Tang Zengqi , Shi Zhenrui , Guo Qing , Xiong Hui
Published: February 2022

Artesunate, one of the derivatives of artemisinin (“qinghaosu” in Chinese), is known as an antimalarial drug with high efficiency and low toxicity. Of interest, emerging evidences suggest that artesunate also possesses an immunomodulatory effect during innate and adaptive immune responses in cell types and context-dependent manner. Although it shows promising application in many diseases, such as inflammatory diseases, hypersensitivity, autoimmune diseases, and cancers, little is known about underlying molecular. In this review, we summarize recent advances of how artesunate regulates innate and adaptive immune cells. In addition, its potential application in immune-related diseases is also highlighted.
Effect of Different Surface Modifications of Acrylic Teeth and Thermocycling on Shear Bond Strength to Polycarbonate Denture Base Material
Authors: Al-Somaiday Humam M. , Rafeeq Aula Kamal , Al-Samaray Manar E.
Published: February 2022

During prosthodontic clinical practice, the most commonly reported type of failure is the debonding of teeth to the denture base. Incompatible surface conditions at the tooth/denture base interface result in a lack of bonding. This study aimed to study the influence of different surface modifications of acrylic teeth and thermocycling on shear bond strength to polycarbonate denture base material. Eighty cylinder-shaped samples were fabricated. The tested samples were divided into 4 groups (n = 20). Group A represents the control group, group B represents the mechanical modification of the tooth, while group C and group D represent the chemical treatment of the tooth with ethyl acetate and bonding agent, respectively. Each group was further subdivided into 2 categories depending on the thermocycling procedure (N = 10). All samples were tested for shear bond strength tests. A computer-controlled universal testing machine performed the shear bond test at a 0.5 mm/min crosshead speed. Three-way ANOVA (

P
=
0.05

) was used for the statistical analysis of the data. Results show that shear bond strength was significantly affected by the surface treatment, whether it is mechanical or chemical (

P
≤
0.01

) (B > D > C) compared with a control group (A). However, thermocycling has a nonsignificant decrease in the bond strength values in all experimental groups (

P
>
0.05

) (B > D > C > A). The mechanical treatment by creating retentive holes (B) provides better results than the chemical surface treatment with a bonding agent and ethyl acetate (D and C, respectively). This study concluded that various surface conditioning methods affect the bonding strength of acrylic teeth and polycarbonate denture base material with no effect of thermocycling.
The Movember Global Action Plan 1 (GAP1): Unique Prostate Cancer Tissue Microarray Resource
Authors: Ouellet Véronique , Erickson Andrew ,   on behalf of GAP1 UTMAs Contributing Investigators, Wiley Kathy , Morrissey Colm , Berge Viktor , Moreno Carlos S. , Tasken Kristin Austlid , Trudel Dominique , True Lawrence D. , Lewis Michael S. , Svindland Aud , Ertunc Onur , Vidal Igor Damasceno , Osunkoya Adeboye O. , Jones Tracy , Bova G. Steven , Lamminen Tarja , Achtman Ariel H. , Buzza Mark , Kouspou Michelle M. , Bigler Steven A. , Zhou Xinchun , Freedland Stephen J. , Mes-Masson Anne-Marie , Garraway Isla P. , Trock Bruce J. , Taimen Pekka , Saad Fred , Mirtti Tuomas , Knudsen Beatrice S. , De Marzo Angelo M.
Published: February 2022

Background:

The need to better understand the molecular underpinnings of the heterogeneous outcomes of patients with prostate cancer is a pressing global problem and a key research priority for Movember. To address this, the Movember Global Action Plan 1 Unique tissue microarray (GAP1-UTMA) project constructed a set of unique and richly annotated tissue microarrays (TMA) from prostate cancer samples obtained from multiple institutions across several global locations.

Methods:

Three separate TMA sets were built that differ by purpose and disease state.

Results:

The intended use of TMA1 (Primary Matched LN) is to validate biomarkers that help determine which clinically localized prostate cancers with associated lymph node metastasis have a high risk of progression to lethal castration-resistant metastatic disease, and to compare molecular properties of high-risk index lesions within the prostate to regional lymph node metastases resected at the time of prostatectomy. TMA2 (Pre vs. Post ADT) was designed to address questions regarding risk of castration-resistant prostate cancer (CRPC) and response to suppression of the androgen receptor/androgen axis, and characterization of the castration-resistant phenotype. TMA3 (CRPC Met Heterogeneity)'s intended use is to assess the heterogeneity of molecular markers across different anatomic sites in lethal prostate cancer metastases.

Conclusions:

The GAP1-UTMA project has succeeded in combining a large set of tissue specimens from 501 patients with prostate cancer with rich clinical annotation.

Impact:

This resource is now available to the prostate cancer community as a tool for biomarker validation to address important unanswered clinical questions around disease progression and response to treatment.
Small-Molecule MMRi62 Induces Ferroptosis and Inhibits Metastasis in Pancreatic Cancer via Degradation of Ferritin Heavy Chain and Mutant p53
Authors: Li Junhui , Lama Rati , Galster Samuel L. , Inigo Joseph R. , Wu Jin , Chandra Dhyan , Chemler Sherry R. , Wang Xinjiang
Published: February 2022

High frequency of KRAS and TP53 mutations is a unique genetic feature of pancreatic ductal adenocarcinoma (PDAC). TP53 mutation not only renders PDAC resistance to chemotherapies but also drives PDAC invasiveness. Therapies targeting activating mutant KRAS are not available and the outcomes of current PDAC treatment are extremely poor. Here, we report that MMRi62, initially identified as an MDM2-MDM4–targeting small molecule with p53-independent pro-apoptotic activity, shows anti-PDAC activity in vitro and in vivo. We show that MMRi62 inhibits proliferation, clonogenic, and spheroid growth of PDAC cells by induction of cell death. MMRi62-induced cell death in PDAC is characteristic of ferroptosis that is associated with increased autophagy, increased reactive oxygen species, and lysosomal degradation of NCOA4 and ferritin heavy chain (FTH1). In addition to induced degradation of FTH1, MMRi62 also induces proteasomal degradation of mutant p53. Interestingly, MMRi62-induced ferroptosis occurs in PDAC cell lines harboring either KRAS and TP53 double mutations or single TP53 mutation. In orthotopic xenograft PDAC mouse models, MMRi62 was capable of inhibiting tumor growth in mice associated with downregulation of NCOA4 and mutant p53 in vivo. Strikingly, MMRi62 completely abrogated metastasis of orthotopic tumors to distant organs, which is consistent with MMRi62's ability to inhibit cell migration and invasion in vitro. These findings identified MMRi62 as a novel ferroptosis inducer capable of suppressing PDAC growth and overcoming metastasis.
Transplant Ureteral Stenosis after Renal Transplantation: Risk Factor Analysis
Authors: Apel Hendrik , Rother Ulrich , Wach Sven , Schiffer Mario , Kunath Frank , Wullich Bernd , Heller Katharina
Published: February 2022

Introduction: The results of kidney transplants have improved dramatically in recent years, leading to reduced morbidity and mortality. Despite continuous improvements, urological complications occur at a rate of 2.6%–15%. Ureteral stenosis of graft ureters is the most common complication, with a probability of 0.5%–6.3%. This study aimed to determine the incidence of ureteral stenosis after kidney transplantation and identify risk factors that distinguish transplant patients with and without ureteral stenosis. Methods: This study retrospectively analyzed patients who had undergone kidney transplantation at the Department of Urology of the Friedrich-Alexander University Erlangen-Nuremberg between 2001 and 2015. Forty-seven patients developed ureteral stenosis during the operation. Most of the ureteral stenosis cases occurred in the first 4 months after transplantation. Kaplan-Meier analysis and the log-rank test were used to calculate the cumulative risk, and the Mann-Whitney U test was used nonparametrically. The significance level was set at p < 0.05. Results: Statistical analysis showed that residual diuresis (p = 0.008), cold ischemia time (CIT) (p = 0.040), the body mass index (p = 0.027), and donor serum creatinine value (p = 0.039) showed a significantly different distribution between recipients with or without ureteral stenosis after kidney transplantation. In multivariate Cox’s regression modeling, residual diuresis and the donor serum creatinine level were identified as the only independent predictors of patients’ stenosis-free survival. Conclusion: Urological complications not diagnosed and treated in time endanger the success of kidney transplantation. After evaluating the kidney transplantation data of the patients at the Transplant Center Erlangen-Nuremberg from 2001 to 2015, residual diuresis, CIT, the body mass index, and donor serum creatinine value were found to influence the development of ureteral stenosis.
Soft Target Weight: Theory and Simulation of a Novel Haemodialysis Protocol Which Reduces Excessive Ultrafiltration
Authors: Ashby Damien , Corbett Richard , Duncan Neill
Published: February 2022

Introduction: Excessive ultrafiltration is associated with intra-dialytic symptoms, loss of residual function, and mortality in haemodialysis patients. A major contributor to excessive ultrafiltration is within-individual variation in pre-dialysis weight and the concept of achieving a fixed target weight by the end of each dialysis session. Haemodialysis protocols which allow variable post-dialysis weight have not been proposed. Methods: Weight variation was observed in haemodialysis patients and healthy controls to estimate the proportion of pre-dialysis weight variation which could be considered natural variation. These estimates were used to derive a novel protocol for setting ultrafiltration, which was evaluated by mathematical modelling. Results: Amongst 20 haemodialysis patients, mean (SD) pre-dialysis weight was 102.74 (0.94)% of target weight after a 2-day gap and 103.50 (0.94)% after a 3-day gap. Amongst 10 healthy individuals, mean (SD) daily weight was 100.0 (0.71)% of average weight. A 4-component model of pre-dialysis weight was derived using these estimates, in which the best estimate of pre-dialysis excess fluid is the midpoint of excess weight and average fluid gain, and used to propose a novel protocol for ultrafiltration setting. In simulations, the novel protocol reduced ultrafiltration variation by more than half (standard deviation 0.6 vs. 1.3% of target weight, p < 0.001), without increasing the variation in post-dialysis fluid excess. Excessive ultrafiltration rates (over 13 mL/h/kg) were far less frequent using this protocol (2.6% vs. 7.5% of sessions, p = 0.001). Conclusion: Considering natural weight variation allows the development of a novel protocol for ultrafiltration in which target weight does not have to be achieved precisely: it is therefore a soft target. This protocol, which is predicted to substantially reduce excessive ultrafiltration variation, is a zero-cost intervention with the potential to improve symptoms and clinical outcome for haemodialysis patients.
Cytological Screening Model of Normal Oral Mucosa Exposed to Carcinogens: A Pilot Study
Authors: Paiva Ricardo Losekann , de Figueiredo Maria Antonia Zancanaro , Cherubini Karen , Da Silva Vinicius Duval , Salum Fernanda Gonçalves
Published: February 2022

Introduction: Oral cytopathology is able to detect incipient cellular alterations, but it is not routinely applied to this purpose. We aimed to establish a model to screen individuals with no oral lesion exposed to smoking/alcohol, by means of the nuclear area, cell proliferation rate, and analysis of genetic damage. Methods: In this cross-sectional pilot study, 90 patients were allocated into 3 groups: oral cancer group (patients with oral squamous cell carcinoma), tobacco/alcohol group (patients without oral lesions and exposed to these risk factors), and control group (individuals with no lesion and not exposed to tobacco and alcohol). The cytological smears performed in these individuals were stained with Papanicolaou, a silver-staining and a Feulgen reaction. The nuclei of cells were measured, and AgNORs/nucleus and micronuclei (MN) were quantified. The cutoff values were stipulated evaluating the healthy mucosa (control group) and the cancerization field mucosa (oral cancer group). Results: Cutoff values for the screening of individuals exposed to carcinogens were ≥8% of nuclei larger than 100 μm2, ≥3.38 AgNOR/nucleus, and ≥3 MN per 1,000 cells. Conclusions: Nuclear area measurement and AgNORs/nucleus and MN quantification identified the incipient phase of oral carcinogenesis. A screening model for individuals without oral lesion exposed to smoking/alcohol was proposed.
Thermoneutral Regulation and Acute Injury: Implications for Acute Kidney Injury
Authors: Curtis Lisa M. , Balkawade Rohan
Published: February 2022

Acute kidney injury (AKI) has demonstrated sex differences as illustrated in clinical and preclinical studies. In most cases, females show a significant resistance to AKI as manifested by renal indicators of injury, and thus much of the literature is derived from studies exclusively in males. Thermoneutral housing alters sex differences in acute injury of the liver, but has not been studied in the kidney. Thermoneutrality, the ambient temperature at which additional energy is not needed to maintain core body temperature, is regulated by mechanisms residing in mitochondria. Importantly, mitochondrial function plays an important role in induction and recovery of AKI. Mechanisms that regulate thermoneutrality include uncoupling proteins (UCPs) and one of its upstream regulators peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α). PGC-1α has been extensively studied in AKI in males. UCP-2, a UCP expressed in the kidney, has been minimally studied in AKI in males. Expression of other UCPs in the kidney has not been well defined. No studies of either PGC-1α or UCPs have interrogated for a sex difference nor have they been investigated at thermoneutrality in the kidney. In this brief review, pathways of importance in thermoneutrality are described and related to pathways of importance in modulating susceptibility to AKI. Clarity in the understanding of the impact of thermoneutrality on AKI in altering susceptibility in females may expand our understanding of the critical role of mitochondrial function in this setting. Unique utilization of mitochondrial-based molecular pathways in females may then inform potential therapies.
ASPECTS-Based Attenuation Changes on CT Angiography as an Imaging Biomarker to Predict Hemorrhagic Transformation in Acute Ischemic Stroke
Authors: Cheng XiaoQing , Shi JiaQian , Wu Hang , Dong Zheng , Liu Jia , Zhou ChangSheng , Liu QuanHui , Su XiaoQin , Shi Zhao , Li YingLe , Xiao LuLu , Zhu WuSheng , Lu GuangMing
Published: February 2022

Introduction: Imaging-based early warning indicators and feasible stratification of acute ischemic stroke (AIS) patients with hemorrhagic transformation (HT), especially high-risk patients with parenchymal hematoma (PH), are crucial in determining subsequent treatment strategies. This study combined automated ASPECTS software with noncontrast CT (NCCT) and CTA source image (CTASI) attenuation changes using Hounsfield unit (HU) values to predict HT and PH in patients with AIS. Materials and Methods: We retrospectively enrolled 172 consecutive patients with anterior circulation large-vessel occlusion between 2016 and 2020. Univariate and multivariate logistic regression and receiver operating characteristic (ROC) analyses were used to investigate the relationship between NCCT and CTASI-ASPECTS-HU, as well as other clinical and radiological parameters of HT and PH. Univariate and multivariate logistic regression analyses were performed to explore risk factors for HT or PH, and an ROC curve was used to evaluate their diagnostic values. Results: A multivariate analysis showed that CTASI-ASPECTS-HU and NIHSS score were independent predictors of HT (CTASI-ASPECTS-HU: odds ratio (OR), 2.22; 95% CI, 1.01–4.92; NIHSS: OR, 1.07; 95% CI, 1.02–1.13) and PH (CTASI-ASPECTS-HU: OR, 6.51; 95% CI, 2.29–18.50; NIHSS: OR, 1.07; 95% CI, 1.01–1.13). According to ROC analysis, CTASI-ASPECTS-HU >0.09 identified HT (area under the curve, 0.70; sensitivity, 70.15%; specificity, 61.90%), and CTASI-ASPECTS-HU >0.10 identified PH (area under the curve, 0.79; sensitivity, 76.19%; specificity, 73.33%). The area under the curve for predicting HT or PH increased when CTASI-ASPECTS-HU was combined with NIHSS score (HT: area under the curve, 0.74; sensitivity, 73.13%; specificity, 70.48%; PH: area under the curve, 0.81; sensitivity, 85.71%; specificity, 72.38%). Conclusion: CTASI-ASPECTS-HU is a reliable radiological predictor of HT and PH in patients with AIS. Its predictive efficacy is moderately improved when combined with NIHSS score.
Improved Stroke Care in a Primary Stroke Centre Using AI-Decision Support
Authors: Gunda Bence , Neuhaus Ain , Sipos Ildikó , Stang Rita , Böjti Péter Pál , Takács Tímea , Bereczki Dániel , Kis Balázs , Szikora István , Harston George
Published: February 2022

Background: Patient selection for reperfusion therapies requires significant expertise in neuroimaging. Increasingly, machine learning-based analysis is used for faster and standardized patient selection. However, there is little information on how such software influences real-world patient management. Aims: We evaluated changes in thrombolysis and thrombectomy delivery following implementation of automated analysis at a high volume primary stroke centre. Methods: We retrospectively collected data on consecutive stroke patients admitted to a large university stroke centre from two identical 7-month periods in 2017 and 2018 between which the e-Stroke Suite (Brainomix, Oxford, UK) was implemented to analyse non-contrast CT and CT angiography results. Delivery of stroke care was otherwise unchanged. Patients were transferred to a hub for thrombectomy. We collected the number of patients receiving intravenous thrombolysis and/or thrombectomy, the time to treatment; and outcome at 90 days for thrombectomy. Results: 399 patients from 2017 and 398 from 2018 were included in the study. From 2017 to 2018, thrombolysis rates increased from 11.5% to 18.1% with a similar trend for thrombectomy (2.8–4.8%). There was a trend towards shorter door-to-needle times (44–42 min) and CT-to-groin puncture times (174–145 min). There was a non-significant trend towards improved outcomes with thrombectomy. Qualitatively, physician feedback suggested that e-Stroke Suite increased decision-making confidence and improved patient flow. Conclusions: Use of artificial intelligence decision support in a hyperacute stroke pathway facilitates decision-making and can improve rate and time of reperfusion therapies in a hub-and-spoke system of care.
Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Blood Safety
Authors: He Baoren , Shi Yaoqiang , Li Bin , Duan Xiaoqiong , Wang Qinghua
Published: February 2022

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it has spread rapidly around the world and caused a serious global social crisis. During the epidemic, the blood collection and supply industry have been greatly impacted, due to the sharply dropped blood donors and transfusion transmission risk of SARS-CoV-2. Many infected individuals are asymptomatic and they may donate blood without awareness of the infection or before symptoms appear. In addition, viral RNAs have been detected in the blood of some patients infected with SARS-CoV-2. Although no infectious SARS-CoV-2 virus was found in the blood nor the blood components, there is a risk of transmission through blood transfusion which may endanger blood safety, especially during the pandemic period. This review briefly introduces the biological characteristics, epidemiology of SARS-CoV-2, with a particular focus on SARS-CoV-2 infection and blood safety.
Frederico Fellini, o cartunista dos neorrealistas
Authors: Lemos Anna Paula
Published: February 2022

Frederico Fellini, o cartunista dos neorrealistas
A colonialidade do poder no conflito armado do Peru (1980-2000)
Authors: Fávari Flávia Eugênia Gimenez
Published: February 2022

A colonialidade do poder no conflito armado do Peru (1980-2000).
O movimento zapatista: Na construção da sua autonomia
Authors: Sánchez Wando Lao Fuentes
Published: February 2022

O movimento zapatista: Na construção da sua autonomia
“A confissão", de Bernardo Santareno: da diferença como locus de luta política
Authors: Santana Solange Santos , Muniz Márcio Ricardo Coelho
Published: February 2022

A dramaturgia de Bernardo Santareno (1920-1980) possibilita lidar com personagens singulares que problematizam a noção de identidade como fixa e homogênea. Consequentemente, tem-se um teatro que denuncia a opressão e a discriminação como parte das relações de poder que produzem a identidade e a diferença. Eis o que acontece em A confissão, texto dramático que integra o volume Os marginais e a Revolução (1979). Ao abordar a transexualidade num contexto pós-revolucionário, Santareno nos brinda com Françoise, uma figura que desloca gênero, sexualidade e corpo para os domínios da ambivalência. Como atravessar fronteiras de gênero ou permanecer nelas é sempre um movimento de resistência, vejamos, pois, como sua presença, em A confissão, está atrelada a seu direito de falar, gritar e se defender por meio de um discurso combativo, ainda que a Revolução dos Cravos não tenha contemplado seus direitos e suas lutas.
Poesia e exílio: passos do decadentismo português
Authors: Andrade Patrícia Helena Baialuna de
Published: February 2022

O período conhecido como fin-de-siècle, que compreende a passagem do século XIX para o século XX, foi marcado por intensas mudanças no cenário artístico europeu; da tendência simbolista ao decadentismo, das vanguardas europeias aos primórdios do modernismo, a época foi de muitas propostas e experiências pelo novo. Ao traçarmos um breve panorama das principais questões sociais e filosóficas que marcaram o cenário português do período, procuramos neste ensaio mostrar de que formas a poesia portuguesa, do simbolismo à Geração de Orfeu, de fato se apropriou das tendências que estavam presentes no discurso de artistas e críticos da época. Trazendo como exemplo alguns trechos de poemas do período, percorremos uma época tendo como fio condutor a postura existencial do eu poético que se sente exilado, não-pertencente ao mundo em franca modernização que o cerca.
Vamos de mãos dadas: Drummond leitor de Camões em A Paixão Medida
Authors: Duarte Daniel Soares
Published: February 2022

Neste artigo, apresento uma interpretação de alguns poemas do livro A paixão medida, de Carlos Drummond de Andrade, tendo em vista seu intertexto com a poesia de Luiz Vaz de Camões. Tratam-se de oito poemas dispostos no livro do poeta brasileiro que podem ser lidos como suporte fundamental à investigação de Drummond acerca da literatura como presença de vida após a morte: evocando Camões em forma, tom e em tópicos, explicitando a recepção do poeta lusitano na extensão dos versos, Drummond trabalha para viver além da vida, tema presente na totalidade do livro citado bem como nos temas dos poemas aqui elencados. Tal estratégia reflete parâmetros da estética da recepção conforme organizados por Hans Robert Jauss e Wolfgang Iser.
Ajuda para almas não pequenas
Authors: Melques Luiz Fernando Queiroz
Published: February 2022

Com ironia e humor, a poeta e pesquisadora portuguesa Patrícia Lino dá a ler seu mais novo livro O Kit de Sobrevivência do Descobridor Português no Mundo Anticolonial. Esta resenha oferece um percurso de leitura pelas linhas de força dessa obra que tem recebido a atenção de leitores portugueses e brasileiros desde sua recente publicação.
Cenas da escrita distópica em Golgona Anghel
Authors: Sales Paulo Alberto da Silva
Published: February 2022

Reflexão sobre a poesia de Golgona Anghel discutindo a relação entre poesia e ética na contemporaneidade. Constata-se, por meio de uma escrita atenta ao cotidiano da cidade (Lisboa) e às vivências do tempo presente, uma discursividade construída por meio da “partilha do sensível”, ou seja, por uma linguagem que afeta os sujeitos e que os leva à consciência da realidade marcada por fracassos e perdas. Observa-se nos gestos de escrita, principalmente nas obras Como uma flor de plástico na montra de um talho (2013) e Nadar na piscina dos pequenos (2017), uma dicção irônica e risível que revela um modo de narrar/partilhar o real em uma poética afetuosa na qual poeta e sujeitos compartilham do desencanto da sociedade do espetáculo. Conclui-se que a distopia latente nas cenas de escrita dos poemas é equilibrada pela partilha de uma linguagem de vai de encontro com o outro.
Expressões de masculinidade entre patrões e operários em um conjunto de empresas sul‑rio-grandenses década de 1940
Authors: Bartmann Tatiane
Published: February 2022

Este artigo tem o objetivo de desenvolver uma reflexão sobre as diferenciações nos padrões de masculinidade levando em consideração classe, etnia e contexto social na análise dos elementos que atuam na construção das masculinidades em dois grupos de indivíduos: os empresários fundadores do Centro da Indústria Fabril (Cinfa) e os trabalhadores desses mesmos estabelecimentos. Através da análise das atas de reuniões do Cinfa e dos processos trabalhistas individuais, trata-se dos estilos de masculinidades e a imagem que os empresários fundadores do Centro se esforçavam em construir ao longo da década de 1940. Nesse sentido, percebe-se que além de ser masculinizado, o dinamismo criador dos empreendedores, em especial dos fundadores do Cinfa, também é racializado e embranquecido pela valorização da germanidade.
Social networks in organizations
Authors: Vargas-Hernández José G. , Morales-del-Rio Cecilia
Published: February 2022

Social networks play a key role in communication-related organizations. Unfortunately, the current literature has only been focused on the use of social networks within communities for creation and interaction between the organization and consumers, concerning mostly digital marketing and branding. Much of this literature falls under two interesting perspectives, the importance of communication in organizations and the use of social networks as a new communication channel. Organizations need communication as part of the understanding between management and employees, whereas social networks integrate agents into digital communities. This study summarizes the literature concerning each of these perspectives to derive assumptions and expected results on communication with social networks within organizations. Then, by means of a sociological perspective, the reconciliation of these views considering the incorporation of social networks as a new form of internal communication for organizations is proposed. There is a need for integration of communities with social networks, based on the context of premises made by previous studies.