bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Study on Characteristics of Lead-Bismuth Lubricated Hydrodynamic Bearing Considering Non-Condensable Gas
Authors: Lyu Kefeng , Zhang Yuanyuan , Ma Xudan , Cheng Zude
Published: September 2024

Lead-Bismuth Eutectic (LBE) is an interesting candidate as a coolant for Generation IV nuclear power plants. Lead-bismuth lubricated radial guide bearing is the key component of the mechanical pump in a lead-bismuth coolant system. In this paper, the transient calculation model of multiphase lubrication flow field of journal bearing is established by using Singhal full cavitation model and structured dynamic grid technique. Due to the saturated vapors of LBE being very low, the effects of different Non-Condensable Gas (NCG) contents on the characteristics of lead-bismuth lubricated journal bearing systems were analyzed. The results show that the NCG content has an obvious influence on the working state of the bearing. With the increase in NCG content, the bearing load capacity decreases. Under the same load, with the increase in NCG content, the eccentricity of the static equilibrium position will be larger, which will increase the risk of bearing contact with the bearing bush. Moreover, the increase of NCG content will lead to the increase of tangential oil film force work, which is helpful to improve rotor stability.
The Influence of a Lubricant Medium on the Development of Fretting Wear in an Interference Fit Connection
Authors: Barta Dalibor , Kowalski Sławomir , Dižo Ján , Dittrich Aleš
Published: September 2024

Fretting wear is a phenomenon occurring in many engineering objects, including push fit connections. In view of a large number of factors conducive to wear development, it is difficult to describe the mechanism of wear initiation and development. Therefore, various methods are sought to limit wear development. The use of a lubricant may be one of those ways. The aim of this article is to present the results of testing the influence of a lubricant medium on the development of fretting wear in interference fit connections. As a lubricant medium, MoS2 and Whitmore greases were used. For that purpose, wear tests were first conducted on the shaft/sleeve tribological kinematic pair, and then observations and laboratory measurements were performed. The observations demonstrated the presence of fretting wear traces on all tested samples, irrespective of the tribological kinematic pair being tested. The main kind of damage consisted of material build-ups which, during operation, become oxidised and, while moving along the connection, caused local abrasion and micropits. The best results in restricting the development of fretting wear were achieved with Whitmore grease.
A Threshold Estimator for Ruin Probability Using the Fourier-Cosine Method in the Wiener–Poisson Risk Model
Authors: Xie Chongkai , You Honglong
Published: September 2024

In this paper, we propose a nonparametric estimator of ruin probability in the Wiener–Poisson risk model based on high-frequency data. The estimator is constructed via the Fourier-cosine method and the threshold technique, and the convergence rate is also studied for a large sample size. Finally, we verify the effectiveness of our estimator through some simulation studies.
AFSMWD: A Descriptor Flexibly Encoding Multiscale and Oriented Shape Features
Authors: Hu Ling , Wang Haibo , Yang Xuguang , Xu Haojun , Liao Yongzhong
Published: September 2024

Shape descriptors are extensively used in shape analysis tasks such as shape correspondence, segmentation and retrieval, just to name a few. Their performances significantly determine the efficiency and effectiveness of subsequent applications. For this problem, we propose a novel powerful descriptor called Anisotropic Fractional Spectral Manifold Wavelet Descriptor (AFSMWD), built upon an extended manifold signal processing tool named Anisotropic Fractional Spectral Manifold Wavelet (AFSMW), which is also presented for the first time in this paper. The novelty of AFSMW is integrating the fractional theory into the common anisotropic spectral manifold wavelet. Compared to the existing wavelets, it provides one more new parameter, namely, the fractional order, to balance or enhance the transform coefficients among different shape vertices, enabling more flexible local shape analysis and more hidden shape structural information explored. Due to the advantages of this added parameter and the capability of analyzing shape features from multiple scales and orientations, the AFSMW allows us to construct the powerful descriptor AFSMWD just using the AFSMW transform coefficients of a very simple function. The proposed descriptor appears to be especially localizable, discriminative, and robust to noises. Extensive experiments have demonstrated that our descriptor has outperformed the state-of-the-art descriptors, nearly achieving 22% improvements to the most related work ASMWD and 69% to the recent popular work WEDS on the FAUST dataset. Its superiorities are also announced in some challenging occasions such as shapes with large deformation or topological partiality.
Correlation between Overweight, Obesity, Gestational Diabetes Mellitus, Adipokines (Adipolin and Adiponectin), and Adverse Pregnancy Outcomes: A Pilot Study
Authors: Mihai Muntean , Vladut Săsăran , Sonia-Teodora Luca , Laura Mihaela Suciu , Victoria Nyulas , Irina Elena Muntean , Claudiu Mărginean
Published: September 2024

Background: The prevalence of overweight (OW), obesity (OB), and gestational diabetes mellitus (GDM) has been increasing worldwide in recent years. Adipolin is a new adipokine with reduced circulating levels in obesity and type 2 diabetes mellitus (T2DM). Objectives: Our prospective case-control study aimed to evaluate the maternal serum levels of adipolin and adiponectin, metabolic parameters, and anthropometric characteristics at the time of oral glucose tolerance test (OGTT) in pregnant women with a pre-pregnancy body mass index (BMI) ≥ 25 Kg/m2 and correlate them with newborn adipolin, adiponectin levels, and anthropometric characteristics of the newborns, and secondly to evaluate pregnancy outcomes. Material and Methods: After the OGTT results, we had 44 OW/OB pregnant women with GDM, 30 OW/OB pregnant women without GDM, and 92 lean healthy (LH) pregnant women. Data were analyzed by ANOVA and correlation tests, with a p-value < 0.05 considered significant. Results: We found no differences between adipolin values of the OW/OB pregnant women with GDM and the LH group (p > 0.99), OW/OB without GDM and the LH group (p = 0.56), and between OW/OB groups (p = 0.57). OW/OB pregnant women with GDM had a higher rate of gestational hypertension compared with the LH group (p < 0.0001). Newborns from OW/OB pregnant women with GDM were more frequently diagnosed with jaundice (p = 0.02), and they required more frequent admission to the neonatal intensive care unit (NICU) for treatment of respiratory distress (p = 0.01) compared with newborns from LH mothers. Conclusions: Our study revealed that the serum levels of adipolin in the second trimester among the group of OW/OB pregnant women with GDM, matched for age and BMI with OW/OB pregnant women without GDM, were not significantly different. This suggests that adipolin may not play an essential role in the occurrence of GDM in these patients. Despite good glycemic control during pregnancy, OW/OB pregnant women with GDM and their newborns tend to have more complications (gestational hypertension, jaundice, NICU admission) than LH pregnant women and their newborns, highlighting the importance of weight control before pregnancy.
Orienteering Is More than Just Running! Acute Effect of Competitive Pressure on Autonomic Cardiac Activity among Elite Orienteering Athletes
Authors: Gorgulu Recep , Oruç Hilal , Vasile Cristian , Corlaci Ionuț , Voinea Florin
Published: September 2024

Background and Objectives: Orienteering is a sport characterized by high physical exertion and intense mental demands, which increase susceptibility to errors. Understanding the impact of such errors on psychophysiological responses, particularly on heart rate variability (HRV), is essential. This study aimed to investigate the relationship between psychophysiological indicators and checkpoint errors made by elite orienteers during official competition. Materials and Methods: Fifty-three orienteers participated in this study, and their performance was continuously monitored and recorded by using a global positioning system (GPS) and HRV data. Errors made during the orienteering events were identified and analyzed. HRV data were examined in three temporal segments: before, during, and after the identified and standardized errors. Results: The analyses indicated that errors significantly impacted HRV indices across multiple domains: the time domain, frequency domain, and nonlinear domain. Additionally, a significant effect of sex on the normalized the root mean square of successive differences (r-MSSD) before and after the error was observed. Conclusions: The findings of this study underscore the significant impact of errors made by orienteers on cardiovascular responses, as evidenced by measurable alterations in HRV metrics. Cardiovascular activity, represented by the HRV, can provide useful information for coaches and sport psychologists to adopt effective training programs for athletes.
Synchronous Seminoma of Testis and Renal Cell Carcinoma: A Rare Case Report
Authors: Auskalnis Stasys , Janciauskiene Rasa , Rimsaite Urte , Alksnyte Aurelija , Ugenskiene Rasa
Published: September 2024

Background and Objectives: Seminoma is the most common solid malignant tumour in young men. Clear-cell kidney carcinoma is the most common malignancy of the genitourinary tract. However, the synchronous occurrence of both of these tumours is rare. Case presentation: We present the case of a 36-year-old patient who presented to a medical facility at the end of 2019 with an enlarged right testicle. A unilateral orchofuniculectomy was performed, and a mass measuring 30 cm was removed. During histological examination, testicular seminoma pT2, R0, was diagnosed. An abdominal computed tomography (CT) scan showed a 6.4 cm × 6.8 cm × 6.7 cm tumour in the right kidney and a metastatic-like lesion in the right adrenal gland. A right nephrectomy and an adrenalectomy and paraaortic and paracaval lymphadenectomies were performed. A histological evaluation confirmed the presence of clear-cell renal carcinoma pT2aR0 G2, adrenal hyperplasia, and seminoma metastases in the removed lymph node. Chemotherapy with a Bleomycin, Etoposide, and Cisplatin (BEP) regimen was carried out. Three years after the last cycle of chemotherapy, a follow-up CT scan showed metastases in the left kidney, the right ischium, and the right lung. A well-differentiated clear-cell carcinoma G1 of the left kidney and metastasis of clear-cell carcinoma G2 in the right ischium were confirmed after the biopsy, and no tumour lesions were found in the lung tissue specimen. Treatment with targeted therapy with Sunitinib was started because the risk was favourable according to the Heng criteria. Genetic testing was performed, and the following genes were analysed: VHL, BAP1, CHEK2, FH, MET, MUTYH, APC, and STK11. The testing did not reveal any pathogenic or potentially pathogenic mutations or sequence changes of unknown clinical significance in the genes analysed. Conclusions: According to the authors, the occurrence of synchronous primary tumours is linked to one’s genetic predisposition. DNA sequencing of tumour tissue could provide more information on the corresponding aetiopathogenesis.
Therapeutic Potential of Vitamin B Complex in Peripheral Nerve Injury Recovery: An Experimental Rat Model Study
Authors: Kahraman Ahmet , Temel Metin , Atilgan Numan , Saray Ahmet , Dokuyucu Recep
Published: September 2024

Objectives: Vitamin B complexes are frequently used in clinical practice for peripheral nerve trauma. However, there is a lack of scientific data on their effectiveness. This study aims to investigate the impact of the vitamin B complex on nerve recovery in a rat model of peripheral nerve paralysis. Materials and Methods: Sixty male Wistar Albino rats were divided into six groups. Models of nerve injury, including blunt trauma, nerve incision, and autograft, were performed on all rats approximately 1 cm distal to the sciatic notch. B-complex vitamins were injected intraperitoneally at 0.2 mL/day to the treatment groups. The control groups were given 0.2 mL/day saline. After 1 month, the study was terminated, electromyography (EMG) was performed to measure the conduction velocity, and nerve tissue was taken from the repair line. The sciatic function indexes (SFIs) were calculated and analyzed. The histopathological samples were stained with hematoxylin and eosin and Toluidine blue and examined with a light microscope. Pathologically, myelination, fibrosis, edema, and mast cell densities in the nervous tissue were evaluated. Results: The vitamin B treatment groups demonstrated significant improvements in SFI compared to the control groups, indicating functional improvement in nerve damage (p < 0.05). In the nerve graft group, the vitamin B group showed a shorter latency, higher velocity, and larger peak-to-peak compared to the controls (p < 0.05). In the nerve transection group, the vitamin B group had better latency, velocity, and peak-to-peak values than the controls (p < 0.05). In the crush injury group, the vitamin B group exhibited an improved latency, velocity, and peak-to-peak compared to the controls (p < 0.05). Better myelination, less fibrosis, edema, and mast cells were also in the vitamin B group (p < 0.05). Conclusions: Vitamin B treatment significantly improves nerve healing and function in peripheral nerve injuries. It enhances nerve conduction, reduces fibrosis, and promotes myelination, indicating its therapeutic potential in nerve regeneration.
Effective Corrosion Inhibition of Galvanic Corrosion of Cu Coupled to Au by Sodium Dodecyl Sulfate (SDS) and Polyethylene Glycol (PEG) in Acid Solution
Authors: Shin HeeKwon , Oh SeKwon
Published: September 2024

This study investigates the effects of sodium dodecyl sulfate (SDS) and polyethylene glycol (PEG) on the galvanic corrosion behavior of copper (Cu) coupled to gold (Au) in a printed circuit board (PCB) etching solution. Galvanic corrosion tests using ZRA (zero resistance ammeter) were performed to determine the optimal SDS concentration for corrosion inhibition. The corrosion current between Cu and Au decreased significantly with the addition of SDS, from 3.26 mA/cm2 to 0.248 mA/cm2 at 4 mM SDS, achieving an inhibitor efficiency (IE) of 92.3%. However, at 15 mM SDS, the corrosion current increased, and IE decreased to 80.5%. This phenomenon is attributed to the critical micelle concentration (CMC) of SDS, where surfactant molecules aggregate and reduce surface adsorption properties. Similarly, ZRA tests were conducted to analyze the effects of PEG on galvanic corrosion. The corrosion current significantly decreased with PEG addition, achieving 98.1% IE at 1 g/L and 99.5% IE at 2 g/L. Beyond this concentration, no significant change in IE was observed, indicating saturation. Potentiodynamic polarization tests were also conducted to study the individual effects of SDS and PEG on Cu and Au. The results showed that SDS effectively inhibited Cu corrosion but had a minimal impact on Au. In contrast, PEG significantly reduced the corrosion current density for both Cu and Au, with reductions of 99.5% and 95.1%, respectively.
Enhanced Mechanical Properties of Ceramic Rod-Reinforced TWIP Steel Composites: Fabrication, Microstructural Analysis, and Heat Treatment Evaluation
Authors: Sun Guojin , Zhu Shengzhi , Li Zhenggui , Wang Qi
Published: September 2024

This study investigates the development and characterization of ceramic rod-reinforced TWIP (twinning-induced plasticity) steel matrix composites, produced using the lost foam casting technique. Mechanical tests revealed a substantial improvement in both flexural strength and ductility, with the composite demonstrating more than double the strength of unreinforced TWIP steel. Furthermore, a simple low-temperature heat treatment further enhanced these properties, increasing the flexural strength of the composite to 1023 MPa while also improving its ductility. The improvement in mechanical performance is attributed to the formation of additional twins in the TWIP steel matrix during deformation following heat treatment, which resulted in further strengthening of the matrix.
Design of a Novel Microlens Array and Imaging System for Light Fields
Authors: Li Yifeng , Li Pangyue , Zheng Xinyan , Liu Huachen , Zhao Yiran , Sun Xueping , Liu Weiguo , Zhou Shun
Published: September 2024

Light field cameras are unsuitable for further acquisition of high-quality images due to their small depth of field, insufficient spatial resolution, and poor imaging quality. To address these issues, we proposed a novel four-focal-square microlens and light field system. A square aspheric microlens array with four orthogonal focal lengths was designed, in which the aperture of a single lens was 100 μm. The square arrangement improves pixel utilization, the four focal lengths increase the depth of field, and the aspheric improves image quality. The simulations demonstrate pixel utilization rates exceeding 90%, depth-of-field ranges 6.57 times that of a single focal length, and image quality is significantly improved. We have provided a potential solution for improving the depth of field and image quality of the light field imaging system.
A Comprehensive Review of Piezoelectric Ultrasonic Motors: Classifications, Characterization, Fabrication, Applications, and Future Challenges
Authors: Naz Sidra , Xu Tian-Bing
Published: September 2024

Piezoelectric ultrasonic motors (USMs) are actuators that use ultrasonic frequency piezoelectric vibration-generated waves to transform electrical energy into rotary or translating motion. USMs receive more attention because they offer distinct qualities over traditional magnet-coil-based motors, such as miniaturization, great accuracy, speed, non-magnetic nature, silent operation, straightforward construction, broad temperature operations, and adaptability. This review study focuses on the principle of USMs and their classifications, characterization, fabrication methods, applications, and future challenges. Firstly, the classifications of USMs, especially, standing-wave, traveling-wave, hybrid-mode, and multi-degree-of-freedom USMs, are summarized, and their respective functioning principles are explained. Secondly, finite element modeling analysis for design and performance predictions, conventional and nano/micro-fabrication methods, and various characterization methods are presented. Thirdly, their advantages, such as high accuracy, small size, and silent operation, and their benefits over conventional motors for the different specific applications are examined. Fourthly, the advantages and disadvantages of USMs are highlighted. In addition, their substantial contributions to a variety of technical fields like surgical robots and industrial, aerospace, and biomedical applications are introduced. Finally, their future prospects and challenges, as well as research directions in USM development, are outlined, with an emphasis on downsizing, increasing efficiency, and new materials.
Enhanced Hybrid Nanogenerator Based on PVDF-HFP and PAN/BTO Coaxially Structured Electrospun Nanofiber
Authors: Yoo Jin-Uk , Kim Dong-Hyun , Jung Eun-Su , Choi Tae-Min , Lee Hwa-Rim , Pyo Sung-Gyu
Published: September 2024

Nanogenerators have garnered significant interest as environmentally friendly and potential energy-harvesting systems. Nanogenerators can be broadly classified into piezo-, tribo-, and hybrid nanogenerators. The hybrid nanogenerator used in this experiment is a nanogenerator that uses both piezo and tribo effects. These hybrid nanogenerators have the potential to be used in wearable electronics, health monitoring, IoT devices, and more. In addition, the versatility of the material application in electrospinning makes it an ideal complement to hybrid nanogenerators. However, despite their potential, several experimental variables, biocompatibility, and harvesting efficiency require improvement in the research field. In particular, maximizing the output voltage of the fibers is a significant challenge. Based on this premise, this study aims to characterize hybrid nanogenerators (HNGs) with varied structures and material combinations, with a focus on identifying HNGs that exhibit superior piezoelectric- and triboelectric-induced voltage. In this study, several HNGs based on coaxial structures were fabricated via electrospinning. PVDF-HFP and PAN, known for their remarkable electrospinning properties, were used as the primary materials. Six combinations of these two materials were fabricated and categorized into homo and hetero groups based on their composition. The output voltage of the hetero group surpassed that of the homo group, primarily because of the triboelectric-induced voltage. Specifically, the overall output voltage of the hetero group was higher. In addition, the combination group with the most favorable voltage characteristics combined PVDF-HFP@PAN(BTO) and PAN hollow, boasting an output voltage of approximately 3.5 V.
A Micromachined Silicon-on-Glass Accelerometer with an Optimized Comb Finger Gap Arrangement
Authors: Li Jiacheng , Feng Rui , Wang Xiaoyi , Cao Huiliang , Gong Keru , Xie Huikai
Published: September 2024

This paper reports the design, fabrication, and characterization of a MEMS capacitive accelerometer with an asymmetrical comb finger arrangement. By optimizing the ratio of the gaps of a rotor finger to its two adjacent stator fingers, the sensitivity of the accelerometer is maximized for the same comb finger area. With the fingers’ length, width, and depth at 120 μm, 4 μm, and 45 μm, respectively, the optimized finger gap ratio is 2.5. The area of the proof mass is 750 μm × 560 μm, which leads to a theoretical thermomechanical noise of 9 μg/√Hz. The accelerometer has been fabricated using a modified silicon-on-glass (SOG) process, in which a groove is pre-etched into the glass to hold the metal electrode. This SOG process greatly improves the silicon-to-glass bonding yield. The measurement results show that the resonant frequency of the accelerometer is about 2.05 kHz, the noise floor is 28 μg/√Hz, and the nonlinearity is less than 0.5%.
A Novel Nano-Spherical Tip for Improving Precision in Elastic Modulus Measurements of Polymer Materials via Atomic Force Microscopy
Authors: Fu Tianyu , Uzoma Paul C. , Ding Xiaolei , Wu Pengyuan , Penkov Oleksiy , Hu Huan
Published: September 2024

Micro-nano-scale mechanical properties are vital for engineering and biological materials. The elastic modulus is generally measured by processing the force–indentation curves obtained by atomic force microscopy (AFM). However, the measurement precision is largely affected by tip shape, tip wear, sample morphology, and the contact model. In such research, it has been found that the radius of the sharp tip increases due to wear during contact scanning, affecting elastic modulus calculations. For flat-ended tips, it is difficult to identify the contact condition, leading to inaccurate results. Our research team has invented a nano-spherical tip, obtained by implanting focused helium ions into a silicon microcantilever, causing it to expand into a silicon nanosphere. This nano-spherical tip has the advantages of sub-micro size and a smooth spherical surface. Comparative tests of the elastic modulus measurement were conducted on polytetrafluoroethylene (PTFE) and polypropylene (PP) using these three tips. Overall, the experimental results show that our nano-spherical tip with a consistent tip radius, symmetrical geometric shape, and resistance to wear and contamination can improve precision in elastic modulus measurements of polymer materials.
An Update on Blastocystis: Possible Mechanisms of Blastocystis-Mediated Colorectal Cancer
Authors: Tocci Stefania , Das Soumita , Sayed Ibrahim M.
Published: September 2024

Blastocystis is an anaerobic parasite that colonizes the intestinal tract of humans and animals. When it was first discovered, Blastocystis was considered to be a normal flora with beneficial effects on human health, such as maintaining gut hemostasis and improving intestinal barrier integrity. Later, with increasing research on Blastocystis, reports showed that Blastocystis sp. is associated with gastrointestinal disorders, colorectal cancer (CRC), and neurological disorders. The association between Blastocystis sp. and CRC has been confirmed in several countries. Blastocystis sp. can mediate CRC via similar mechanisms to CRC-associated bacteria, including infection-mediated inflammation, increased oxidative stress, induced gut dysbiosis, and damage to intestinal integrity, leading to a leaky gut. IL-8 is the main inflammatory cytokine released from epithelial cells and can promote CRC development. The causal association of Blastocystis sp. with other diseases needs further investigation. In this review, we have provided an update on Blastocystis sp. and summarized the debate about the beneficial and harmful effects of this parasite. We have also highlighted the possible mechanisms of Blastocystis-mediated CRC.
Hass Avocado (Persea americana Mill) Peel Extract Reveals Antimicrobial and Antioxidant Properties against Verticillium theobromae, Colletotrichum musae, and Aspergillus niger Pathogens Affecting Musa acuminata Colla Species, in Ecuador
Authors: Donoso Caterine , Raluca Mihai A. , Chávez-Jinez Stephanie , Vera Edwin
Published: September 2024

The utilization of agroindustrial residues, such as avocado peel, as a source of bioactive compounds with antioxidant properties has garnered significant attention. In this study, we investigated the antioxidant potential using the DPPH (2,2-diphenyl-1-picrylhydrazyl) and ORAC (oxygen radical absorbance capacity) methods, along with the antimicrobial activity of phenolic compounds extracted from Hass avocado peel. These soluble polyphenols were quantified and identified using high-performance liquid chromatography (HPLC). The research focused on their effects against three fungal pathogens, Verticillium theobromae, Colletotrichum musae, and Aspergillus niger, which significantly impact banana crops, an essential agricultural commodity in Ecuador. The results have revealed that the application of 80% ethanol as an organic solvent led to increased soluble polyphenol content compared to 96% ethanol. Extraction time significantly influenced the phenolic content, with the highest values obtained at 90 min. Interestingly, despite substantial mycelial growth observed across all extract concentrations, the antifungal effect varied among the pathogens. Specifically, V. theobromae exhibited the highest sensitivity, while C. musae and A. niger were less affected. These results underscore the importance of considering both antioxidant and antimicrobial properties when evaluating natural extracts for potential applications in plant disease management.
Characterization of Trap States in AlGaN/GaN MIS-High-Electron-Mobility Transistors under Semi-on-State Stress
Authors: Liang Ye , Duan Jiachen , Zhang Ping , Low Kain Lu , Zhang Jie , Liu Wen
Published: September 2024

Devices under semi-on-state stress often suffer from more severe current collapse than when they are in the off-state, which causes an increase in dynamic on-resistance. Therefore, characterization of the trap states is necessary. In this study, temperature-dependent transient recovery current analysis determined a trap energy level of 0.08 eV under semi-on-state stress, implying that interface traps are responsible for current collapse. Multi-frequency capacitance–voltage (C-V) testing was performed on the MIS diode, calculating that interface trap density is in the range of 1.37×1013 to 6.07×1012cm−2eV−1 from EC−ET=0.29 eV to 0.45 eV.
Selective Copolymerization from Mixed Monomers of Phthalic Anhydride, Propylene Oxide and Lactide Using Nano-Sized Zinc Glutarate
Authors: Zhang Xiaoting , Li Zhidong , Wang Liyan , Yu Jingjing , Liu Yefan , Song Pengfei
Published: September 2024

Selective polymerization with heterogeneous catalysts from mixed monomers remains a challenge in polymer synthesis. Herein, we describe that nano-sized zinc glutarate (ZnGA) can serve as a catalyst for the selective copolymerization of phthalic anhydride (PA), propylene oxide (PO) and lactide (LA). It was found that the ring-opening copolymerization (ROCOP) of PA with PO occurs firstly in the multicomponent polymerization. After the complete consumption of PA, the ring-opening polymerization (ROP) of LA turns into the formation of block polyester. In the process, the formation of zinc–alkoxide bonds on the surface of ZnGA accounts for the selective copolymerization from ROCOP to ROP. These results facilitate the understanding of the heterogeneous catalytic process and offer a new platform for selective polymerization from monomer mixtures.
Hierarchical Interfacial Construction by Grafting Cellulose Nanocrystals onto Carbon Fiber for Improving the Mechanical Performance of Epoxy Composites
Authors: Ma Yanjiao , Zhao Wei , Xiong Jun , Zhang Wei , Dai Mingfeng , Guo Yifan , Li Ying , Long Ling , Zhou Zuowan
Published: September 2024

Carbon fiber-reinforced composites have been widely used in the aerospace industry because of their superior comprehensive performance, including high strength, low density, fatigue resistance, long service life, etc. The interface between the fiber reinforcement and the matrix is one of the key factors that determines the performance of the composites. The construction of covalent bonding connections between the components has proven to be an effective strategy for improving the interfacial bonding strength but always reduces the toughness. In this work, dual silane coupling agents are applied to covalently connect cellulose nanocrystals (CNCs) onto carbon fibers, constructing hierarchical interfacial connections between the fibers and the epoxy matrix and significantly improving the interfacial bonding strength. As a result, the tensile strength of the epoxy composites increased from 519 MPa to nearly 900 MPa, which provides a potential approach for significantly improving the mechanical performance of composites.
Daily Orange Consumption Reduces Hepatic Steatosis Prevalence in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: Exploratory Outcomes of a Randomized Clinical Trial
Authors: Notarnicola Maria , Tutino Valeria , De Nunzio Valentina , Cisternino Anna Maria , Cofano Miriam , Donghia Rossella , Giannuzzi Vito , Zappimbulso Marianna , Milella Rosa Anna , Giannelli Gianluigi , Fontana Luigi
Published: September 2024

Background: Consumption of flavonoid-rich orange juice has been shown to reduce adiposity and liver steatosis in murine models of diet-induced obesity. However, little is known about the effects of whole orange intake, independent of body weight changes, on liver function and steatosis in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD). The goal is to understand the direct impact of orange consumption on metabolic health. Methods: Sixty-two men and women aged 30–65 with MASLD (Controlled Attenuation Parameter, (CAP) > 275 dB/m) were randomly assigned to consume either 400 g of whole oranges or non-citrus fruits daily for 4 weeks. Baseline evaluations included medical assessments, blood tests, and body composition. Liver health was assessed using transient elastography (FibroScan®) for steatosis and fibrosis, conducted by blinded personnel. This clinical trial was registered at ClinicalTrials.gov (NCT05558592). Results: After 4 weeks of orange supplementation, liver steatosis decreased in the treatment group, with 70.9% showing steatosis compared to 100% in controls (p < 0.004), indicating a 30% reduction in liver disease prevalence. There were no significant changes in fibrosis or plasma liver enzymes, though plasma gamma glutaril transferase (GGT) levels decreased significantly. Body weight, waist circumference, body composition, lipid profile, fasting glucose, insulin, and C-reactive protein levels remained unchanged. Dietary analysis revealed no change in caloric intake, but vitamins C, A, thiamine, and riboflavin increased in the orange group. Conclusions: Our findings suggest that phytochemical-rich foods, especially whole fruits like oranges, may enhance liver function as an adjunct treatment for MASLD. The notable reduction in liver steatosis prevalence occurred independently of body weight changes. Further studies are needed to investigate the long-term effects of orange supplementation on steatosis and fibrosis progression and to identify the specific bioactive compounds and mechanisms involved.
A New Strategy for Dietary Nutrition to Improve Intestinal Homeostasis in Diarrheal Irritable Bowel Syndrome: A Perspective on Intestinal Flora and Intestinal Epithelial Interaction
Authors: Wu Xinyu , Cao Yilong , Liu Yixiang , Zheng Jie
Published: September 2024

Background and objectives: Although a reasonable diet is essential for promoting human health, precise nutritional regulation presents a challenge for different physiological conditions. Irritable Bowel Syndrome (IBS) is characterized by recurrent abdominal pain and abnormal bowel habits, and diarrheal IBS (IBS-D) is the most common, seriously affecting patients’ quality of life. Therefore, the implementation of precise nutritional interventions for IBS-D has become an urgent challenge in the fields of nutrition and food science. IBS-D intestinal homeostatic imbalance involves intestinal flora disorganization and impaired intestinal epithelial barrier function. A familiar interaction is evident between intestinal flora and intestinal epithelial cells (IECs), which together maintain intestinal homeostasis and health. Dietary patterns, such as the Mediterranean diet, have been shown to regulate gut flora, which in turn improves the body’s health by influencing the immune system, the hormonal system, and other metabolic pathways. Methods: This review summarized the relationship between intestinal flora, IECs, and IBS-D. It analyzed the mechanism behind IBS-D intestinal homeostatic imbalance by examining the interactions between intestinal flora and IECs, and proposed a precise dietary nutrient intervention strategy. Results and conclusion: This increases the understanding of the IBS-D-targeted regulation pathways and provides guidance for designing related nutritional intervention strategies.
Daily Adequate Intake of Fruit and Vegetables and All-Cause, Cardiovascular Disease, and Cancer Mortalities in Malaysian Population: A Retrospective Cohort Study
Authors: Tan Lay Kim , Zainuddin Nabilah Hanis , Tohar Najjah , Sanaudi Ridwan , Cheah Yong Kang , Omar Mohd Azahadi , Kee Chee Cheong
Published: September 2024

Background/Objective: We investigated the relationship between daily adequate FV intake and risk of all-cause, cardiovascular disease (CVD), and cancer mortalities among Malaysian adults. Methods: Data from a total of 18,211 Malaysian adults aged 18 years and above whom participated in the National Health and Morbidity Survey 2011 were analyzed. The participants were followed up for approximately 11 years, and mortality data were ascertained through record linkages with the death registry from the Malaysian National Registration Department. Multiple Cox regression was applied to assess the association between daily adequate FV intake and risk of all-cause, CVD, and cancer mortalities, adjusting for sociodemographic, lifestyle, and health conditions. Results: During the follow-up period, we observed a total of 1809 all-cause, 374 CVD, and 216 cancer mortalities. No significant association between daily adequate FV intake with all-cause mortality (adjusted hazard ratio (aHR): 1.01, 95% confidence interval (CI: 0.79–1.31), CVD mortality (aHR: 0.91, 95% CI: 0.57–1.47), and cancer mortality (aHR: 1.27, 95% CI: 0.74–2.17) were observed, even after excluding deaths that occurred in the first two years of observation. Conclusions: Further investigation on the type of FV intake and its preparation method with risk of mortality will provide a holistic insight into the causal relationship between FV intake and mortality.
Transplant-Acquired Food Allergy in Children
Authors: Indolfi Cristiana , Klain Angela , Dinardo Giulio , Grella Carolina , Perrotta Alessandra , Colosimo Simone , Decimo Fabio , Miraglia del Giudice Michele
Published: September 2024

Background: Organ transplantation in children is a vital procedure for those with end-stage organ failure, but it has been linked to the development of post-transplant allergies, especially food allergies. This phenomenon, known as transplant-acquired food allergy (TAFA), is becoming increasingly recognized, though its mechanisms remain under investigation. Pediatric transplant recipients often require lifelong immunosuppressive therapy to prevent graft rejection, which can alter immune function and heighten the risk of allergic reactions. Our review aimed to gather the latest evidence on TAFA. Methods: We conducted a PubMed search from 25 June to 5 July 2024, using specific search terms, identifying 143 articles. After screening, 36 studies were included: 24 retrospective studies, 1 prospective study, 2 cross-sectional researches, and 9 case reports/series. Results: Most studies focused on liver transplants in children. The prevalence of food allergies ranged from 3.3% to 54.3%. Tacrolimus, alongside corticosteroids, was the most commonly used immunosuppressive therapy. In addition to food allergies, some patients developed atopic dermatitis, asthma, and rhinitis. Allergic symptoms typically emerged within a year post-transplant, with common allergens including milk, eggs, fish, nuts, soy, wheat, and shellfish. Both IgE-mediated and non-IgE-mediated reactions were observed, with treatment often involving the removal of offending foods and the use of adrenaline when necessary. Conclusions: Consistent immunological monitoring, such as skin prick tests and IgE level assessments, is essential for early detection and management of allergies in these patients. Understanding the link between transplantation and allergy development is crucial for improving long-term outcomes for pediatric transplant recipients.
Real-Time Fluorescence Monitoring System for Optimal Light Dosage in Cancer Photoimmunotherapy
Authors: Tanaka Hideki , Koga Yoshikatsu , Sugahara Mayumi , Fuchigami Hirobumi , Ishikawa Akihiro , Yamaguchi Toru , Banba Akiko , Shinozaki Takeshi , Matsuura Kazuto , Hayashi Ryuichi , Sakashita Shingo , Yasunaga Masahiro , Yano Tomonori
Published: September 2024

Background/Objectives: Near-infrared photoimmunotherapy (NIR-PIT) was recently approved for the treatment of unresectable locally advanced or recurrent head and neck cancers in Japan; however, only one clinical dose has been validated in clinical trials, potentially resulting in excessive or insufficient dosing. Moreover, IRDye700X (IR700) fluorescence intensity plateaus during treatment, indicating a particular threshold for the antitumor effects. Therefore, we investigated the NIR laser dose across varying tumor sizes and irradiation methods until the antitumor effects of the fluorescence decay rate plateaued. Methods: Mice were subcutaneously transplanted with A431 xenografts and categorized into control, clinical dose (cylindrical irradiation at 100 J/cm², frontal irradiation at 50 J/cm²), and evaluation groups. The rate of tumor IR700 fluorescence intensity decay to reach predefined rates (−0.05%/s or −0.2%/s) until the cessation of light irradiation was calculated using a real-time fluorescence imaging system. Results: The evaluation group exhibited antitumor effects comparable to those of the clinical dose group at a low irradiation dose. Similar results were observed across tumor sizes and irradiation methods. Conclusions: In conclusion, the optimal antitumor effect of NIR-PIT is achieved when the fluorescence decay rate reaches a plateau, indicating the potential to determine the appropriate dose for PIT using a real-time fluorescence monitoring system.
Unlocking the Potential of Silver Nanoparticles: From Synthesis to Versatile Bio-Applications
Authors: Almatroudi Ahmad
Published: September 2024

Silver nanoparticles (AgNPs) are leading the way in nanotechnological innovation, combining the captivating properties of silver with the accuracy of nanoscale engineering, thus revolutionizing material science. Three main techniques arise within the alchemical domains of AgNP genesis: chemical, physical, and biological synthesis. Each possesses its distinct form of magic for controlling size, shape, and scalability—key factors necessary for achieving expertise in the practical application of nanoparticles. The story unravels, describing the careful coordination of chemical reduction, the environmentally sensitive charm of green synthesis utilizing plant extracts, and the precise accuracy of physical techniques. AgNPs are highly praised in the field of healthcare for their powerful antibacterial characteristics. These little warriors display a wide-ranging attack against bacteria, fungi, parasites, and viruses. Their critical significance in combating hospital-acquired and surgical site infections is highly praised, serving as a beacon of hope in the fight against the challenging problem of antibiotic resistance. In addition to their ability to kill bacteria, AgNPs are also known to promote tissue regeneration and facilitate wound healing. The field of cancer has also observed the adaptability of AgNPs. The review documents their role as innovative carriers of drugs, specifically designed to target cancer cells with accuracy, minimizing harm to healthy tissues. Additionally, it explores their potential as cancer therapy or anticancer agents capable of disrupting the growth of tumors. In the food business, AgNPs are utilized to enhance the durability of packing materials and coatings by infusing them with their bactericidal properties. This results in improved food safety measures and a significant increase in the duration that products can be stored, thereby tackling the crucial issue of food preservation. This academic analysis recognizes the many difficulties that come with the creation and incorporation of AgNPs. This statement pertains to the evaluation of environmental factors and the effort to enhance synthetic processes. The review predicts future academic pursuits, envisioning progress that will enhance the usefulness of AgNPs and increase their importance from being new to becoming essential within the realms of science and industry. Besides, AgNPs are not only a subject of scholarly interest but also a crucial component in the continuous effort to tackle some of the most urgent health and conservation concerns of contemporary society. This review aims to explore the complex process of AgNP synthesis and highlight their numerous uses, with a special focus on their growing importance in the healthcare and food business sectors. This review invites the scientific community to explore the extensive possibilities of AgNPs in order to fully understand and utilize their potential.
Molded Round Window Niche Implant as a Dexamethasone Delivery System in a Cochlear Implant-Trauma Animal Model
Authors: Wei Chunjiang , Gao Ziwen , Mau Robert , Eickner Thomas , Jüttner Gabor , Fiedler Nicklas , Seitz Hermann , Lenarz Thomas , Scheper Verena
Published: September 2024

Background: Preserving residual hearing after cochlear implant (CI) surgery remains a crucial challenge. The application of dexamethasone (DEX) has been proven to positively affect residual hearing. To deliver DEX in a localized and controlled way, a round window niche implant (RNI), allowing drug diffusion via the round window membrane into the cochlea, may be used. To prove this concept, an RNI for guinea pigs as a CI-trauma model was manufactured by molding and tested for its drug release in vitro and biological effects in vivo. Methods: The RNIs were molded using silicone containing 10% DEX. Release was analyzed over time using high-performance liquid chromatography (HPLC). Fourteen adult guinea pigs were randomly assigned to two groups (CI or CI + RNI group). All animals received a unilateral CI electrode insertion trauma followed by CI insertion. The CI + RNI group was additionally implanted with an RNI containing 10% DEX. Animals were followed up for 4 weeks. Acoustically evoked auditory brainstem response and impedance measurement, micro-computed tomography (µCT) imaging, and histology were performed for evaluation. Results: DEX was released for more than 250 days in vitro, with an initial burst followed by a slower release over time. Comparing the hearing threshold shift (from day 0 to day 28) of the CI and CI + RNI groups, significant differences were observed at 32 and 40 kHz. The impedance shift at basal contacts was lower in the CI + RNI group than in the CI group. Moreover, the fibrosis in the lower basal turn was reduced in the CI + RNI group in contrast to the CI group. Conclusions: The RNI containing 10% DEX has anti-inflammatory potential concerning fibrosis inhibition and has beneficial effects on hearing preservation at high frequencies.
Biochemical and Epigenetic Regulation of Glutamate Metabolism in Maize (Zea mays L.) Leaves under Salt Stress
Authors: Eprintsev Alexander T. , Anokhina Galina B. , Selivanova Polina S. , Moskvina Polina P. , Igamberdiev Abir U.
Published: September 2024

The effect of salt stress (150 mM NaCl) on the expression of genes, methylation of their promoters, and enzymatic activity of glutamate dehydrogenase (GDH), glutamate decarboxylase (GAD), and the 2-oxoglutarate (2-OG)–dehydrogenase (2-OGDH) complex was studied in maize (Zea mays L.). GDH activity increased continuously under salt stress, being 3-fold higher after 24 h. This was accompanied by the appearance of a second isoform with lower electrophoretic mobility. The expression of the Gdh1 gene strongly increased after 6–12 h of incubation, which corresponded to the demethylation of its promoter, while Gdh2 gene expression slightly increased after 2–6 h and then decreased. GAD activity gradually increased in the first 12 h, and then returned to the control level. This corresponded to the increase of Gad expression and its demethylation. Salt stress led to a 2-fold increase in the activity of 2-OGDH during the first 6 h of NaCl treatment, then the activity returned to the control level. Expression of the genes Ogdh1 and Ogdh3 peaked after 1–2 h of incubation. After 6–8 h with NaCl, the expression of these genes declined below the control levels, which correlated with the higher methylation of their promoters. We conclude that salt stress causes a redirection of the 2-OG flux to the γ-aminobutyric acid shunt via its amination to glutamate, by altering the expression of the Gdh1 and Gdh2 genes, which likely promotes the assembly of the native GDH molecule having a different subunit composition and greater affinity for 2-OG.