bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurogenic inflammation induced by capsaicin in patients with psoriasis.
Authors: Glinski W , Glinska-Ferenz M , Pierozynska-Dubowska M
Published: July 2023

Increasing doses of capsaicin were applied topically to the forearm skin of 30 patients with psoriasis, 16 patients with systemic scleroderma and 16 healthy volunteers. Only one-third of the patients with psoriasis responded with neurogenic inflammation to capsaicin doses of 0.125 and 0.25 microgram/cm2 in contrast to 81% of scleroderma patients and all the normal controls, who showed a positive cutaneous reaction. Higher doses of capsaicin (0.5-4 micrograms/cm2) were required to induce erythema and flare in patients with late-onset psoriasis (after 21 years of age) as well as in patients with more than 40% of skin surface involved with psoriatic lesion.
Lipophagic panniculitis in re-excision specimens.
Authors: Zelickson B D , Winkelmann R K
Published: July 2023

Lipophagic panniculitis consists of a macrophage infiltrate in the subcutaneous tissue. The macrophages transform into foam cells within the panniculus they replace lipocytes and may form giant cells. Although those pathologic features have been described as diagnostic of Weber-Christian disease, we report the occurrence of lipophagic panniculitis in re-excision specimens. Among 252 re-excision specimens from previously biopsied skin tumors, 5 cases in which masses of lipophages were infiltrating and replacing the subcutaneous tissue were found. The infiltrate was localized to the deep dermis and superficial subcutaneous tissue below and beside the initial biopsy site. In 3 cases, suture or hair was detected within the tissue, and granulation tissue with foreign body giant cells was observed along the dermal suture line. In 4 cases there was evidence of phlebitis within or close to areas of infiltration. None of these patients developed symptomatic panniculitis. Lipophagia can be a normal response of wound healing in some patients.
Cutaneous vasculitis induced by food additives.
Authors: Veien N K , Krogdahl A
Published: July 2023

A case of leukocytoclastic vasculitis in a 24-year-old woman is described. A severe eruption of vasculitis occurred after placebo-controlled oral challenge with 50 mg ponceau. The patient was asked to adhere to a diet free from food additives, and the vasculitis faded after a period of 2 months.
Candida albicans grown in glucose-free media contains serum-independent chemotactic activity.
Authors: Brasch J , Schröder J M , Christophers E
Published: July 2023

Infection of skin with Candida albicans is usually followed by infiltration of neutrophil granulocytes (PMN). So far, chemotaxins for PMN have been isolated from C. albicans cultures grown in the presence of glucose. However, since glucose is not present in skin in vivo, a contribution of such factors to Candida-triggered cutaneous inflammation would appear unlikely. In order to clarify this question, chemotactic activity was measured in extracts from three different strains of C. albicans which were grown in five different peptone media free of carbohydrates and serum. In addition, four culture systems were supplemented with lipids normally present in human stratum corneum, including a triglyceride, cholesterol, and sphingomyelin. In all sugar-free grown cultures, serum-independent chemotactic activity was detected by use of the Boyden chamber technique. Since, as shown here in vitro, production of neutrophil chemotaxins by C. albicans is independent of glucose-feeding, a possible role of Candida-chemotaxins in the pathophysiology of cutaneous candidosis can no longer be excluded.
Abnormal expression of Ki-67 antigen in hair follicle of alopecia areata.
Authors: Van Baar H M , Perret C M , Van Vlijmen I M , Van de Kerkhof P C , Happle R , Schalkwijk J
Published: July 2023

The monoclonal antibody Ki-67 was used to determine the numbers of cycling cells in hair follicles both in alopecia areata and in normal scalp skin. Pronounced nuclear staining was limited to the area below the critical line of Auber and the exterior part of the outer root sheath. In alopecia areata there is reduced nuclear Ki-67 binding in the bulb of anagen hair follicles. These findings indicate that inhibition of keratinocyte proliferation might be a pathogenetic mechanism in alopecia areata.
Interleukin-6 in normal skin and psoriasis.
Authors: Castells-Rodellas A , Castell J V , Ramirez-Bosca A , Nicolas J F , Valcuende-Cavero F , Thivolet J
Published: July 2023

Interleukin-6 (IL-6 or BSF-2/IFN beta 2) is a component of normal human skin. IL-6 was immunologically detected in basal keratinocytes, endothelial cells and in a number of mononucleated cells and fibroblasts in normal skin and sudoriparous ducts. In psoriasis, intense labelling of the cytoplasm in the vicinity of keratinocyte membranes was detected in all epidermal layers and other skin appendages. The fact that this interleukin acts synergistically with respect to IL-1 and Tumour Necrosis Factor (TNF) strengthens the hypothesis whereby IL-6 may contribute via its receptor action to EGF function in modulating cell hyper-proliferation in psoriasis.
Alcohol and smoking: risk factors for infectious eczematoid dermatitis?
Authors: Karvonen J , Poikolainen K , Reunala T , Juvakoski T
Published: July 2023

Risk factors for infectious eczematoid dermatitis (IED) were analyzed in a study of males aged 19-50 years. The subjects were 43 IED patients and 226 controls with other skin diseases from the dermatological outpatient clinics of three University Hospitals in Finland. The patients' lifestyles were assessed by a self-administered questionnaire pertaining to two specified periods: the period 12 months before the onset of the skin disease and the period 12 months before the examination date. Recalled mean alcohol intake before the onset of the skin disease was 39.2 g/day for the IED patients and 17.1 g/day for the controls (p = 0.04). The average number of cigarettes smoked daily was 17.7 for the IED patients and 10.4 for the control patients (p = 0.001). The IED patients significantly reduced their alcohol intake after the onset of the skin disease. In logistic regression analysis, IED associated with alcohol intake and smoking but not with coffee consumption, life events, age, marital status, or social group. The odds ratio for IED at an alcohol intake of 50 g/day as against no intake, was 1.7 (95% confidence interval 1.03-2.7), and the odds ratio at a tobacco consumption rate of 20 cigarettes/day as against no use of tobacco, was 2.1 (1.2-3.7). We conclude that alcohol intake and smoking appear to be risk factors for infectious eczematoid dermatitis among males.
Schnitzler's syndrome (urticaria and macroglobulinemia) associated with pseudoxanthoma elasticum.
Authors: Machet L , Vaillant L , Machet M C , Esteve E , De Muret A , Khallouf R , Arbeille B , Muller C , Lorette G
Published: July 2023

Schnitzler's syndrome, first described in 1974, is defined by chronic non-pruritic urticaria, osteocondentation, and a monoclonal IgM dysproteinemia, but without criteria of lymphoproliferative disease. We report a patient with chronic urticaria and macroglobulinemia. In addition, he had double monoconal dysproteinemia IgM kappa (31.3 g/l) and IgA lambda, osteocondensation, and some cutaneous lesions of pseudoxanthoma elasticum. Only 20 cases of Schnitzler's syndrome have been reported hitherto. This is the first case associated with pseudoxanthoma elasticum, which was localized and discovered at the same time as Schnitzler's syndrome. We discuss the possible role of monoclonal immunoglobulin in the occurrence of localized elastorrexhis.
Purification of bullous pemphigoid IgG subclasses and their capability for complement fixation.
Authors: Suzuki M , Harada S , Yaoita H
Published: July 2023

The antibody reactivity and complement fixing capability of circulating IgG subclass antibodies of patients with bullous pemphigoid (BP) were investigated. Four subclasses of polyclonal IgG were purified from the sera of BP patients. The first stage of purification was a combination of chromatographies on DEAE Affi-Gel Blue and protein A-Cellulofine columns. The four polyclonal IgG subclasses were then isolated from the above-mentioned semi-purified subclass fractions using IgG subclass-specific immuno-affinity chromatographies. Using an immunohistopathological technique, IgG deposits were detected at the basement membrane zone (BMZ) in the normal skin incubated with IgG subclasses other than IgG3. C3 deposits were detected at BMZ in the skin incubated with IgG1. Neither IgG nor C3 deposits were in skin incubated with IgG3. These findings suggest that the subclasses of circulating BP antibodies are IgG1, IgG2 and IgG4, but not IgG3. Moreover, only the BP IgG1 subclass appears to fix complement.
Objective prick test evaluation: non-invasive techniques.
Authors: Berardesca E , Gabba P , Nume A , Rabbiosi G , Maibach H I
Published: July 2023

Prick test reactions are evaluated and quantified, comparing visual assessment with two non-invasive techniques: remittance spectroscopy and pulsed ultrasound for erythema and skin thickness measurements. Different information is provided by the two methods. Remittance spectroscopy discriminates well between negative and positive reactions (+ or ++), while failing to differentiate stronger reactions, where edema is a prominent feature. The latter reactions are better evaluated by skin thickness measurements, which, on the contrary, are less sensitive in revealing small skin thickness increases in weak reactions.
Skin sensitization to cinnamic alcohol: the role of skin metabolism.
Authors: Basketter D A
Published: July 2023

Cinnamic alcohol and cinnamic aldehyde are a cause of allergic contact dermatitis in man and give rise to similar rates of positive reactions in routine patch testing. However, data from animal models indicates that the aldehyde is the stronger sensitizer of the two. Circumstantial evidence has pointed to the conversion of alcohol to aldehyde in skin as the cause of cinnamic alcohol sensitization. This report discusses the subject in the light of studies of skin metabolism of cinnamic alcohol. Evidence of limited cross reactivity between cinnamic alcohol and cinnamic aldehyde is supported by data showing conversion of cinnamic alcohol to cinnamic aldehyde by an epidermal enzyme.
Rheumatoid arthritis: an association with pemphigus foliaceous.
Authors: Wilkinson S M , Smith A G , Davis M J , Hollowood K , Dawes P T
Published: July 2023

We have observed a high incidence of pemphigus foliaceous, in the absence of therapy with penicillamine, within a small population of patients with rheumatoid arthritis. We suggest that penicillamine as well as inducing autoimmune disease might exacerbate subclinical pemphigus foliaceous in this group, accounting for those few patients whose skin disease fails to resolve following drug withdrawal. Pemphigus and rheumatoid arthritis have both been associated with HLA DR4, which was present in all three of our patients who were tested.
PUVA treatment of vitiligo: a retrospective study of 59 patients.
Authors: Wildfang I L , Jacobsen F K , Thestrup-Pedersen K
Published: July 2023

We have performed a retrospective study of 59 patients with vitiligo who received PUVA therapy from 1972 to 1986. Sixteen patients had generalized vitiligo and 43 vitiligo in four locations (focal vitiligo). In both groups there were repigmentation in 44% of the patients. Half of the repigmented patients had improved more than 50%. None developed hypertrichosis, actinic keratosis, lentigines, or skin cancer within the observation period. Regardless of the results of PUVA therapy half of the patients thought PUVA was an acceptable therapy.
Elimination diet in young children with atopic dermatitis.
Authors: Broberg A , Engström I , Kalimo K , Reimers L
Published: July 2023

Thirteen children with severe current atopic dermatitis unresponsive to topical treatment were started on an elimination diet. One child was excluded because she could only keep to the diet for 3 days. Twelve children aged 0.8-4.1 years maintained the diet for 2-4 weeks. In six children the dermatologist's score showed a clear improvement while on diet, in 2 children there was a minor improvement and in 4 children the dermatologist's score did not change during elimination diet. Challenges were performed with egg, milk and wheat in 6 children and with milk and wheat in 2 children. The challenges were done in an open way except for the dermatologist, who was unaware of which food the child had received. No child in the study had an immediate reaction but 3 children had late reactions, one after egg, one after milk and one child after challenge with wheat.
Interferon-alpha therapy in atopic dermatitis.
Authors: Torrelo A , Harto A , Sendagorta E , Czarnetzki B M , Ledo A
Published: July 2023

Thirteen patients with a severe adult form of atopic dermatitis (AD) received 3.0 x 10(6) IU of recombinant interferon-alpha 2a (rIFN-alpha 2a) 3 times a week. A satisfactory response was obtained in 5 of them. Serum IgE levels in all 13 patients remained unchanged throughout the study. Flu-like symptoms were common, but clinical or laboratory adverse effects were otherwise slight. The moderately beneficial therapeutic effects observed in this study support a possible role for IFN-alpha in controlling immunologic deficiencies in atopic dermatitis.
Altered expression of beta/2/microglobulin in basaloid proliferations overlying dermatofibromas.
Authors: Rossen K , Hou-Jensen K , Werdelin O
Published: July 2023

The epidermis overlying 2/8% of dermatofibromas shows basaloid proliferations that are indistinguishable from superficial basal cell carcinoma. It is well established that basal cell carcinomas uniformly exhibit a strongly reduced expression of HLA class I molecules. Nineteen dermatofibromas with overlying basaloid proliferations were studied by immunohistochemistry using a monoclonal antibody against beta/2/microglobulin, the invariant chain of the HLA class I molecule. The basaloid proliferations exhibited the same strong reduction in expression of beta/2/microglobulin as demonstrated in basal cell carcinomas. We suggest that this phenomenon may represent a proliferative change induced by the mesenchymal cells of the underlying dermatofibroma.
Moisturizers prevent irritant dermatitis.
Authors: Hannuksela A , Kinnunen T
Published: July 2023

The purpose of this study was to investigate the ability of eight different moisturizers to prevent irritant dermatitis. Twelve healthy female students washed the outer aspect of their upper arms with a liquid detergent for one minute twice a day for one week. Seven skin creams and one skin oil were applied to 3 x 7 cm areas of the left upper arm just after each washing, while the right upper arm was left untreated. Transepidermal water loss (TEWL) (mean) increased from 7.1 to 9.3 g/m2/h (p less than 0.001) and laser-Doppler flowmetry (LDF) value (mean) decreased from 11.8 to 10.8 arbitrary units (N.S.) in the left upper arm, but there was no statistical difference between the eight moisturizers. During the second week of the study, the test subjects did not continue washing their arms. Eight areas (3 x 7 cm) of the right upper arm were treated with the moisturizers twice a day. The mean TEWL value decreased from 20.3 to 8.6 (p less than 0.0011) over 7 days, but there were no significant differences between the individual moisturizers. The laser-Doppler values showed the same trend as the TEWL values. In conclusion, regular use of emollients prevented irritant dermatitis from a detergent.
Folinic acid rescue used routinely in psoriatic patients with known methotrexate "sensitivity".
Authors: Hills R J , Ive F A
Published: July 2023

Many combinations of methotrexate and folic or folinic acid have been used to limit the side effects of methotrexate therapy in psoriasis or psoriatic arthropathy. Methotrexate inhibits the enzyme dihydrofolate reductase and prevents the formation of DNA and RNA. Folinic acid, the 5-formyl derivative of tetrahydrofolic acid, is the active form of folic acid. We have confirmed in 5 patients that continuous administration of folinic acid with weekly oral methotrexate prevents improvement of psoriasis. When folinic acid was ceased on the day of methotrexate in these patients their psoriasis improved. Five other patients with previous sensitivity to methotrexate, forcing cessation of therapy, were given weekly oral methotrexate and folinic acid every day except the day of methotrexate. Marked improvement of psoriasis or arthropathy occurred in each case without side effects. This method precisely limits the exposure to methotrexate, allowing a therapeutic effect without complication even in those patients who exhibit methotrexate sensitivity.
Transepidermal water loss related to volar forearm sites in humans.
Authors: Panisset F , Treffel P , Faivre B , Lecomte P B , Agache P
Published: July 2023

The aim of this study was to demonstrate differences in human skin transepidermal water loss (TEWL) in vivo related to site on volar forearm. Fourteen healthy volunteers entered the study and seven sites were tested. After randomization of both forearm and measure order, TEWL measurements were performed using the Servo Med Evaporimeter. TEWL values next to the wrist were found statistically greater than on the other sites. Hence wrist region should preferably be excluded from TEWL measurements on forearm.
Cutaneous paraneoplastic syndromes.
Authors: Politi Y , Ophir J , Brenner S
Published: July 2023

A review of a variety of cutaneous paraneoplastic conditions is presented. Although the conditions discussed appear in only 7/15% of cancer patients, they are considered indicators of possible underlying malignancy.
The SAPHO syndrome.
Authors: Vohradníková O , Záruba F , Polásková S , Hoza J , Leiská A
Published: July 2023

We report two cases of the SAPHO syndrome (synovitis, acne conglobata, pustulosis palmoplantaris, hyperostosis and osteitis). This syndrome has been published in the pediatric and rheumatological literature in recent years.
Recurrent condylomata acuminata treated with recombinant interferon alpha/2a. A multicenter double/blind placebo/controlled clinical trial. Condylomata International Collaborative Study Group.
Authors: Listed No authors
Published: July 2023

A randomized, double/blind, placebo/controlled, international multicenter trial was conducted, using 1.5 MIU subcutaneous interferon alpha/2a 3 times a week for 4 weeks in 170 patients (interferon, n = 125 or placebo, n = 45) with condylomata acuminata who had failed to respond to standard therapies. There was no difference in efficacy between the interferon alpha/2a and placebo treatment groups at 3 months after commencement of therapy. Although the recurrence rate at the end of 9 months' follow/up appeared lower in the interferon alpha/2a group than in the placebo group (9% versus 22%), this difference was not statistically significant. Most of the adverse events reported were typical interferon/associated mild to moderate flu/like symptoms. It is concluded that subcutaneous interferon alpha/2a, administered according to the current dosage and treatment schedule, is not effective as monotherapy in the treatment of refractory condylomata acuminata.
Chloroquine phosphate: a long/term follow/up of drug concentrations in skin suction blister fluid and plasma.
Authors: Sjölin-Forsberg G , Berne B , Blixt C , Johansson M , Lindström B
Published: July 2023

Chloroquine is known to bind strongly to melanin and is accumulated in the skin. In dermatology, the drug is mainly used to treat photosensitivity disorders, but it has also been reported to cause sun sensitivity, especially in patients with rheumatoid arthritis. In the present study the concentrations of chloroquine phosphate in plasma and skin suction blister fluid (interstitial fluid in the skin) from 16 patients were studied by HPLC at steady/state (after 2 months' ingestion of 250 mg of the drug daily) and 2, 4 and 6/7 months after cessation of therapy. At steady/state the concentrations were similar in the two compartments, whereas after discontinuation the drug remained much longer in the skin than in the plasma. In tests using cow's eye melanin in vitro, UV irradiation failed to interact with the binding of chloroquine to melanin. It is speculated that the prolonged storage of the drug in the skin could be of importance for its therapeutic as well as adverse effects.
Chronic urticaria due to nickel intake.
Authors: Abeck D , Traenckner I , Steinkraus V , Vieluf D , Ring J
Published: July 2023

A case of chronic urticaria is presented. The case of the disease was traced back to nickel intake by food as judged from type I and IV sensitization to nickel, a positive oral challenge test and long/standing, complete healing under a nickel/restrictive diet.
The treatment of phimosis in boys, with a potent topical steroid (clobetasol propionate 0.05%) cream.
Authors: Jørgensen E T , Svensson A
Published: July 2023

In an open trial, including 54 boys with phimosis, treatment with clobetasol propionate cream (Dermovate, Glaxo, UK) was shown to be effective, without side effects. Surgery, the treatment of choice in many centres, was avoided in 70% of the patients.
Expression of the alpha 6 beta 4 integrin by squamous cell carcinomas and basal cell carcinomas: possible relation to invasive potential?
Authors: Rossen K , Dahlstrøm K K , Mercurio A M , Wewer U M
Published: July 2023

We have studied the expression of alpha 6 beta 4 integrin, a carcinoma laminin receptor in ten squamous cell carcinomas (SCCs) and ten basal cell carcinomas (BCCs) of the skin in order to examine whether changes in alpha 6 beta 4 integrin expression may be related to invasive and metastatic potential. Monoclonal antibodies specific for each subunit were applied on cryosections, using a three step indirect peroxidase technique. In normal epidermis the basal cells expressed both the alpha 6 and the beta 4 subunits, and the expression was polarized against the basement membrane. In SCCs the expression of the alpha 6 and the beta 4 subunits paralleled each other, showing an increased intensity and loss of polarity. The BCCs, however, showed consistently decreased expression of both the alpha 6 and the beta 4 subunits. The results of our study, as well as those of other studies, support the assumption that the increase and depolarization of alpha 6 beta 4 integrin that occurs in SCCs might be related to the invasive properties of this tumour type.
Rapid assay of the anti-inflammatory activity of topical corticosteroids by inhibition of a UVA-induced neutrophil infiltration in hairless mouse skin. I. The assay and its sensitivity.
Authors: Woodbury R A , Kligman L H
Published: July 2023

A single large dose of UVA induced an intense infiltration of neutrophils into the lower dermis of hairless mouse skin, peaking at 24 h. The ability of 15 name brand topical corticosteroids to suppress this infiltrate was determined. The rank order of suppression correlated with the accepted clinical category of anti-inflammatory potency. This is a rapid screening procedure for assaying the anti-inflammatory activity of new steroids and for optimizing the vehicle.
Clinical effect of the copper vapour laser compared to previously used argon laser on cutaneous vascular lesions.
Authors: Jonell R , Larkö O
Published: July 2023

The copper vapour laser has in theory qualities which make it interesting in the treatment of cutaneous vascular malformations. In order to study the clinical effect of the copper vapour laser and to compare its effect with the effect of the argon laser, we treated 38 patients with port-wine stain or facial telangiectasia with the copper vapour laser. Thirty-one patients were evaluated and of these 24 were improved or much improved. Nineteen patients had previously been treated with the argon laser, and in this group the copper vapour laser had better effect than the argon laser in 8 patients and equal effect in 9 patients. In 7 patients side-effects like scarring or hyperpigmentation were noted after treatment with copper vapour laser.
Generalized normolipemic plane xanthomatosis associated with relapsing polychondritis.
Authors: Yoshimura T , Aiba S , Tadaki T , Tagami H
Published: July 2023

Generalized normolipemic plane xanthomatosis is a rare cutaneous disorder, frequently associated with reticuloendothelial diseases and some disorders with inflammation. Relapsing polychondritis is also a rare disease that shows an association with various immune-mediated diseases. We report a case of generalized normolipemic plane xanthomatosis associated with relapsing polychondritis in a 56-year-old Japanese man. We have already reported the clinical picture of relapsing polychondritis as well as an increase in urinary glycosaminoglycans excretion in this patient. During subsequent treatment with various immunosuppressive therapy, including prednisone, methotrexate, azathioprine, or aurothiomalate, multiple elevated yellowish erythematous plaques appeared on his neck approximately 32 months after the onset of relapsing polychondritis. Histologically, these eruptions consisted of perivascular neutrophilic infiltrate with nuclear dust and multiple foam cells among collagen bundles, compatible with those of generalized normolipemic plane xanthomatosis. This combination of two rare diseases has not been reported in the literature to our knowledge.
UV irradiation induces the expression of gelatinases in human skin in vivo.
Authors: Koivukangas V , Kallioinen M , Autio-Harmainen H , Oikarinen A
Published: July 2023

UV irradiation results in marked changes in skin connective tissue, such as degeneration of collagen, and abnormal elastosis. The mechanism of connective tissue damage by UV has not been clarified in detail. In the present study the mechanism of actinic damage was studied by assaying gelatinases, 72-kDa (MMP-2) and 92-kDa (MMP-9), from suction blister fluids induced on patients who had received either UVB or PUVA treatments. The results indicate that both UVB and PUVA increase the levels of gelatinases in human skin. By in situ hybridization, it was also possible to show that UV irradiation induced increased levels of gelatinase mRNAs in fibroblasts. Furthermore, in samples from severe actinic damage, gelatinase mRNAs were abundantly present, suggesting that gelatinases may contribute to photodamage.
Nickel patch test reactivity and the menstrual cycle.
Authors: Rohold A E , Halkier-Sørensen L , Andersen K E , Thestrup-Pedersen K
Published: July 2023

Premenstrual exacerbation of allergic contact dermatitis and varying allergic patch test responses have been reported at different points of the period. Using a dilution series of nickel sulphate, we studied the variation in patch test reactivity in nickel allergic women in relation to the menstrual cycle. Twenty women with regular periods were tested on day 7-10 and on day 20-24. Ten nickel patch tests with different concentrations were applied using the TRUE test assay, and the threshold concentration of nickel sulphate eliciting an erythematous reaction was determined. Half of the women were tested first on day 7-10 and the other half first on day 20-24. There was no difference in the degree of patch test reactivity, when the results from day 7-10 and day 20-24 were compared (p > 0.4). However, when we compared the patch test results from the first and second test procedure, we found an increased nickel sensitivity at the second patch test (0.02 < p < 0.05), suggesting a booster effect from the first patch test procedure. In conclusion, we could not demonstrate an increased sensitivity to nickel sulphate patch tests premenstrually in 20 nickel allergic women, but we found that elicitation of positive patch tests led to an increased skin reactivity towards the same allergen, when the patients were retested weeks later.
POEMS syndrome and multiple angioproliferative lesions mimicking generalized histiocytomas.
Authors: Del Río R , Alsina M , Monteagudo J , Torremorell D , González U , Luelmo J , Mascaró J M
Published: July 2023

A case of POEMS syndrome and Castleman's multicentric disease is reported. Multiple long-standing cutaneous lesions, histologically similar to histiocytomas, were the initial manifestation of POEMS syndrome. A high incidence of angiomatous lesions associated with POEMS syndrome has already been established. To our knowledge, this report is the first report to associate multiple angioproliferative lesions mimicking generalized histiocytomas with POEMS syndrome.
IgG-Fc receptors in stratum granulosum: an immunological defence in human skin?
Authors: Bjerke J R , Tigalonova M , Matre R
Published: July 2023

Receptors for the Fc-part of IgG (Fc tau R) in stratum granulosum of normal human skin were examined using cryosections and indirect immunofluorescence staining with 1) soluble immune complexes and 2) monoclonal antibodies (MoAbs) against different types of Fc tau R, i.e. 32.2 (anti-Fc tau I-CD64), IV.3 (anti-Fc tau RII-CD32) and Leu 11b (anti-Fc tau RIII-CD16). The immune complexes gave staining corresponding to stratum granulosum in sections from all skin specimens. Inhibition experiments showed that pre-incubation of the sections with monomeric and heat-aggregated human IgG, periodic acid and formaldehyde inhibited the immune complex binding. F(ab')2 containing immune complexes did not bind to the skin sections. The MoAb 32.2 gave granular and Leu 11b linear staining corresponding to stratum granulosum. In addition, both IC, 32.2 and Leu 11b gave weaker staining of keratinocytes in other parts of the epidermis. IV.3 stained epidermal Langerhans' cells and were unreactive with other epidermal cells. Indirect immunofluorescence staining with MoAbs against IgG subclasses showed the presence of all IgG subclasses in stratum granulosum. The results show that granulosum cells express both high- and low-affinity IgG receptors and in vivo bound IgG. The data point to a role for stratum granulosum in cutaneous immunity.
Intralesional interferon alpha-2b therapy for Buschke-Loewenstein tumour.
Authors: Tsambaos D , Monastirli A , Kapranos N , Georgiou S , Pasmatzi E , Berger H
Published: July 2023

A patient with a Buschke-Loewenstein tumour associated with human papillomavirus type 6/11 is reported. He was intralesionally treated with human recombinant alpha-2b interferon (9 x 10(6) IU/day) three times weekly. The tumour completely disappeared within 5 months of continuous treatment which was well tolerated. Sixteen months after completion of therapy the patient remains well and free of disease.
BKB_Social sustainability in Swedish multicultural preschools
Authors: Olsson Åsa
Published: July 2023

Although principals in Swedish preschools treasure cultural diversity and multilingualism, diversity also involves challenges to preschool staff. They may find themselves in a position where there is no way of cooperating with parents, as prescribed in the preschool curriculum (Swedish National Agency for Education, 2018), without counteracting preschools’ fundamental values. These values concern promoting democracy, human rights, gender equality and diversity – fundamental social sustainability goals. In this study, 14 preschool principals were interviewed in focus groups. The results of the study are explored through ‘dilemmatic spaces’ (Honig, 1996), a conceptual framework useful for analysing teachers’ everyday practice. Dilemmatic spaces suggest that dilemmas are ever-present in a particular setting, such as preschools, and that this shifts the responsibility for a challenging situation from the individual to a structural level. The concept has been developed by Fransson and Grannäs (2013). This article presents dilemmas that may arise when preschool staff working in multicultural preschools strive to uphold fundamental values stipulated in the curriculum.
REALITAS KEJAHATAN DAN EKSITENSI TUHAN DALAM PERSPEKTIF FILSAFAT PROSES WHITEHEAD
Authors: Siti Mustaghfiroh
Published: July 2023

ABSTRAK

                Segala sesuatu yang dikategorikan sebagai kejahatan sudah ada sejak sejarah awal manusia ada di muka bumi. Pada umumnya tindakan manusia yang dapat dikategorikan sebagai kejahatan selalu dilihat atau dipahami dari sudut pandang ilmu khusus terutama dari sudut pandang ilmu hukum, ilmu psikologi dan ilmu sosial. Tindakan kejahatan jarang dipahami dari sudut pandang ilmu filsafat. Pada umumnya analisis ilmiah-akademis tentang kejahatan selalu terkait dengan ilmu-ilmu khusus.

               Dalam penelitian ini akan memahami masalah kejahatan dan eksistensi Tuhan dari sudut pandang ilmu filsatat. Dengan menggunakan pemikirian filsafat proses Whitehead, penelitian ini mencoba menguraikan dan mendamaikan masalah kejahatan dan eksistensi tuhan secara komprehensif. Bagi teisme proses, Tuhan  bukanlah pengada absolut bagi seluruh entitas aktual, termasuk apa yang dikategorikan sebagai kejahatan, tetapi Tuhan dalam gradasinya sendiri bertindak sebagai penyokong keseluruhan keteraturan alam, juga menyediakan sumber-sumber baru bagi keteraturan itu. Kejahatan dalam hal ini dianggap sebagai suatu proses tersendiri. Adanya kejahatan di dunia ini tidak dianggap sebagai sesuatu yang menggugurkan eksistensi Tuhan.

Kata kunci: kejahatan, Eksistensi Tuhan, Filsafat Proses
Politik Identitas Era Post-Truth di Indonesia dalam Perspektif Language Games Ludwig Wittgenstein
Authors: Lengga Wangge Gregorius Loudowick , Wijanarko Robertus
Published: July 2023

Tulisan ini bertujuan untuk menggali pemikiran Language Games Ludwig Wittgenstein yang sekiranya sesuai untuk merawat dunia politik Indonesia. Pada era post-truth ini, Indonesia sebagai bangsa yang plural sedang diterjang fenomena politik identitas dengan mengusung isu keagamaan. Kebenaran tidak lagi mudah untuk dikenali secara objektif karena adanya unsur politik kepentingan berkedok identitas, dengan dalihnya yang melibatkan aspek emosional publik. Alhasil kebenaran objektif menjadi tersamarkan oleh nuansa emosional keagamaan yang terbentuk. Dalam menganalisis fenomena tersebut, kami menggunakan metode pembacaan kritis atas fenomena politik identitas keagamaan di Indonesia dalam perspektif pemikiran Wittgenstein. Melalui perspektif Language Games Ludwig Wittgenstein, kami hendak menyadarkan kembali jati diri pluriformitas Bangsa Indonesia dalam semangat Bhinneka Tunggal Ika. Melalui pemikiran Wittgenstein, penulis hendak menganalisis kemajemukan bangsa Indonesia sebagai suatu fakta objektif yang menggambarkan realitas bangsa Indonesia sesungguhnya. Realitas pluriformitas tersebut adalah realitas yang tidak terbantahkan dan menyadarkan setiap rakyatnya akan adanya otonomi, adanya language games masing-masing yang tidak dapat dicampuradukkan. Maka dari itu, untuk mewujudkan persatuan dan kesatuan perlu idealisasi ke arah kesatuan yang saling menghargai. Hal itu terangkum dalam semboyan Bhinneka Tunggal Ika.
RENT-SEEKING TOWARDS ECONOMIC GROWTH: EMPIRICAL STUDY IN LOWER-MIDDLE-INCOME COUNTRIES
Authors: Sugiharti Retno , Laut Lorentino , Febrianti Erika
Published: July 2023

The good effects of globalization are not felt by all countries. Lower-middle-income countries are constrained by ineffective or poorly implemented economic policies in those countries. One indicator of this ineffectiveness is the low rate of controlling rent-seeking in lower-middle-income countries. Therefore, this study analyzes the effect of controlling rent-seeking on the economic growth of lower-middle-income countries. It is important to study where economic growth has an important role in the economic development of lower-middle-income countries. This study also uses control variables such as capital formation, population, and lag of economic growth through the Partial Adjustment Model (PAM) approach. Based on the results of regression testing that has been carried out, controlling rent seeking and capital formation is known to have a positive and significant effect on economic growth in lower-middle-income countries. Meanwhile population has a negative and significant effect on the economic growth of lower-middle-income countries.
Consistency and Ability of Students Using DINA and DINO Models
Authors: Wafa Mohammad Nasim , Zia Ziauddin , Frozan Fazlahmad
Published: July 2023

There are two prevalent models for studying cognitive diagnosis Models  for appraisement and diagnostics, each of these two models is the definite Input Noisy Output “and” gate  and the Deterministic Input Noisy Output “or” gate  models. The usage of them is to display various views of the ways cognitive skills are related and the probability of how an  responds correctly. The aim of  study is to compare the mentioned models and girls and boys  with the modeling of cognitive diagnosis. The aims of this study  to identify differences in performance of Afghan boys’ and girls’ students in the basic mathematical attributes and cognitive skills of the eighth grade in TIMMS (2011). As well as rankings among the countries that participated in TIMMS. Two commonly used CDMs were employed to fit the response data, including these two models (DINA and DINO). With the assistance of CDMs, we could obtain not only the item parameters, but also the skill profile for each student. Results show that the examinees do best in number domain while do worst in data and chance.
WEBSITE PROMOSI WISATA BARU DI WILAYAH YOGYAKARTA DENGAN PENDEKATAN LEAN UX
Authors: Ramadhan Akbar , Mardhia Murein Miksa , Anwar Nuril
Published: July 2023

Website resmi pariwisata Indonesia saat ini didesain untuk mampu menampilkan daftar tujuan daerah, dimana apabila salah satu daftar tersebut dipilih, informasi yang ditampilkan masih hanya berupa nama, deskripsi, jumlah yang disukai, jumlah yang dilihat dan penjelasan tentang daerah tersebut. Informasi tersebut belum lengkap untuk wisatawan yang ingin mencari atau menentukan tujuan wisata, terutama destinasi wisata baru yang populer dan viral. Solusi yang dapat membantu adalah pengembangan fitur baru yang dapat menampilkan daftar tempat wisata beserta informasi detail yang lengkap. Penelitian ini menerapkan metode Lean UX untuk pengembangan aplikasi yang fokus pada kecepatan pengembangan dengan mereduksi fitur yang bukan prioritas dalam siklus. Metode ini terdiri dari 4 tahapan yaitu Declare Assumptions, create an MVP, Run an Experiment, Feedback and Research. Website promosi wisata baru di Yogyakarta ini dapat menampilkan informasi tujuan wisata secara detail seperti kategori, fasilitas, jam berkunjung dan lokasi dengan menampilkan gambar peta lokasi. Berdasarkan pengujian yang telah dilakukan dengan menyebarkan kuesioner yang berisi 10 pernyataan kepada 5 responden maka pada iterasi 1 mendapatkan angka sebesar 49,5 dan iterasi 2 mendapatkan 80,5
ABSENSI PEGAWAI BERBASIS ANDROID PADA SD BHAKTI MANDALA NABIRE MENGGUNAKAN METODE WATERFALL
Authors: Lapi Daniel , Prayitno Gunawan
Published: July 2023

SD Bhakti Mandala  merupakan  salah satu Lembaga pendidikan Swasta di  Kabupaten  Nabire yang memiliki tugas dan tanggung jawab dalam mendidik peserta didik untuk mencapai  hak anak dalam pendidikan. Dalam mencapai kesuksesan  suatu instansi dalam pendidikan  tak  hanya dalam  proses  belajar dan mengajar  tetapi  dari  aspek lain juga termaksud  kehadiran. Dari  informasi  yang  penulis  dapatkan, bahwa  di  SD  Bhakti  Mandala  Nabire masi menggunakan cara  manual  dalam   pengisian  absen  serta  pengolahan   laporan kehadiran.  Untuk itu  SD  Bhakti Mandala Nabire perlu sistem  yang mempermudah dewan  guru dan  staff tatausaha  dalam  mengolah kehadiran. Penelitian ini  bertujuan merancang   sistem  aplikasi absensi berbasis  android  pada  SD Bhakti  Mandala  Nabire Menggunakan metode waterfall.  Tujuan utama dari penelitian ini  untuk merubah sistem absensi yang lebih mudah dan tepat  melalui  penggunaan teknologi. Aplikasi ini memberikan kemudahan  bagi pegawai dalam melakukan absensi  dan  memudahkan  pihak  sekolah  dalam  memantau  kehadiran   pegawai.   Selain  itu,  sistem  ini  dapat memberikan data absensi yang tercatat  secara  real-time, sehingga  memudahkan proses  penggajian dan analisis kinerja pegawai.   Hasil  penelitian   ini  diharapkan   dapat  menjadi  pedoman   bagi  sekolah  untuk  meningkatkan kedisiplinan kehadiran.
APLIKASI PENDATAAN BARANG BERBASIS WEB DI TOKO BANGUNAN SINAR KUDUS
Authors: Rosdiana Irma , Pusvita Ester Ayuk
Published: July 2023

Toko Bangunan Sinar Kudus Nabire merupakan sebuah toko bangunan yang menggunakan sistem pendataan barang secara manual atau tertulis. Hal ini membuat pemilik toko bangunan kesusahan dalam mencari data barang jika toko memiliki jumlah barang yang banyak. Diperlukan solusi untuk mengatasi permasalahan tersebut, oleh karena itu penulis membuat sebuah penelitian yang menghasilkan sebuah aplikasi berbasis web yang mudah digunakan dan mudah diakses. Dengan adanya aplikasi ini, pemilik toko bangunan beserta karyawan yang bekerja dapat lebih mudah mencatat, mencari, dan mengedit data barang yang ada di toko sehingga pekerjaan menjadi lebih efisien.
METODE AGILE SCRUM DALAM PEMBUATAN APLIKASI PERMOHONAN INFORMASI E-PPID BAWASLU
Authors: Roilan Raihanna Ilfa Widjayanti , Yulianto Pramuji Arif , Astuti Yuli
Published: July 2023

Bawaslu Sleman merupakan lembaga yang bertugas mengawasi jalannya pemilihan umum. Seperti lembaga pemerintah yang lain Bawaslu sleman memiliki website resmi, sayangnya penataan dari informasi yang tersedia tidak tertata dengan baik. Seiring berjalannya waktu pengguna aplikasi mobile semakin banyak sehingga dibutuhkan lah aplikasi android untuk menunjang kebutuhan tersebut. Dengan adanya aplikasi android untuk lembaga diharapkan masyarakat dapat mengakses informasi dengan lebih tersusun dan efisien. Aplikasi ini dikembangkan dengan metode agile scrum dengan menggunakan bahasa pemrograman android kotlin dan menerapkan server database sql untuk penyimpanan data. Pembuatan aplikasi mobile ini di buat berdasarkan dengan wawancara yang telah dilakukan pada lembaga, sehingga mendapatkan akses informasi serta kebutuhan yang valid.
Turmas multisseriadas no ensino básico brasileiro
Authors: Lichand Guilherme , Schweickardt Kátia , De Campos Gabriel , Simões Armando
Published: July 2023

Turmas multisseriadas são aquelas nas quais alunos de mais de uma série são alocados na mesma sala de aula. Em 2019, havia mais de 80 mil dessas turmas no Brasil, contemplando mais de 1,2 milhão de alunos. Este estudo se concentra nos dois terços destas que não incluem alunos da educação infantil – as chamadas turmas multi. Descrevemos as características dos alunos, professores e gestores associados às turmas multi com base no Censo Escolar 2019, contrapondo essas turmas às unisseriadas no contexto do ensino fundamental. Essa análise revela uma concentração espacial relevante das turmas multi em certos estados e municípios – em alguns dos quais chegam a representar mais de 60% das matrículas. De um lado, turmas multi envolvem vários desafios adicionais em relação às unisseriadas: cada docente precisa não apenas dominar uma gama muito mais ampla de conteúdos, como ainda ser capaz de ensinálos simultaneamente – o que exige formação específica, como confirmamos mediante entrevistas com 55 docentes de Manicoré, Amazonas. De outro lado, essas turmas se concentram em regiões com menos recursos, em escolas com piores condições de infraestrutura e nas quais menos docentes têm formação específica, além de serem menos experientes e acumularem funções. Discutimos ainda como o fato de turmas multisseriadas não serem avaliadas pelo Sistema de Avaliação da Educação Básica implica uma série de desafios para políticas de promoção de equidade, desde falta de conhecimento sobre a proficiência desses alunos até incentivos perversos que levam essas turmas a serem negligenciadas por recursos e formações das secretarias de educação. Por fim, utilizamos um modelo estatístico para prever o Índice de Desenvolvimento da Educação Básica das turmas multi e conjecturamos como sua inclusão nesse índice afetaria o nosso entendimento sobre proficiência e a distribuição de recursos da educação básica.
Qualidade da educação superior
Authors: Ferreira Ma Janaina , Zalaf Caseiro Luiz Carlos , Cavalcanti Mundim Fabiano
Published: July 2023

Este estudo tem o objetivo de subsidiar o debate sobre como a dimensão da qualidade da educação superior pode ser abordada no novo Plano Nacional de Educação (PNE), previsto para o decênio 2024-2034. Com base em pesquisa documental e entrevistas com ocupantes de cargos da alta gestão do Estado brasileiro, envolvidos com políticas de educação superior, levantamos categorias de análise referentes à qualidade da educação superior no Brasil. Concluímos que, se o foco do primeiro PNE foi no aumento das vagas e o do segundo foi na expansão das matrículas, o foco do terceiro PNE deve ser no aumento do número de concluintes, com uma oferta de vagas orientada ao equilíbrio e à eficiência do sistema. Com base nesse entendimento, oferecemos um conjunto de recomendações e metas relacionadas à qualidade da educação superior. Esperamos que os resultados deste estudo se somem às demais pesquisas realizadas sobre o tema, contribuindo para municiar os debates sobre como a qualidade da educação superior pode ser contemplada no novo PNE.

Este trabalho não seria possível sem a participação dos entrevistados e das entrevistadas que encontraram tempo em suas disputadas agendas para conversar conosco. Por isso, deixamos nossos sinceros agradecimentos a Ana Maria Ferreira de Mattos Rettl, Alysson Massote Carvalho, Carlos Eduardo Moreno Sampaio, Helena Maria Sant’Ana Sampaio Andery, Manuel Fernando Palacios da Cunha e Melo, Leonardo Monteiro de Souza Tostes, Luiz Roberto Liza Curi, Thérèse Hofmann Gatti Rodrigues da Costa, Tomás Dias Sant´Ana, Ulysses Tavares Teixeira e Wagner Vilas Boas de Souza.
Aciertos y desafíos de la reincorporación económica de mujeres excombatientes en Colombia
Authors: Rojas Quintero Samuel , Acevedo Valencia Jenny Marcela , Gallego Tavera Sindy Yuliana
Published: July 2023

Este artículo de revisión bibliográfica tiene como objetivo dar cuenta de la producción académica y jurídica referida a los aciertos y desafíos que presentan los procesos de reincorporación económica de mujeres excombatientes de las FARC-EP en Colombia. Como resultados se encuentra que el componente económico se constituye en un factor determinante para los procesos de reincorporación, por ello en los acuerdos se pactaron acciones como el censo socioeconómico, la identificación y puesta en marcha de programas y proyectos productivos, además del acceso de una renta básica mensual. Sin embargo, este tema es sensible debido a que por parte del gobierno no se han  cimentado las bases para la creación de nuevos empleos, tan necesarios para esta población que no cuenta con experiencia laboral certificada. En el caso de la reincorporación económica de mujeres, la situación no es distinta, ellas deben asumir en muchos casos la jefatura del hogar e ingresar a un mercado laboral que las excluye por su escasa experiencia laboral, también deben asumir con mayor rigor el estigma y la indiferencia ciudadana, que no reconoce el rol como sujetos políticos que desempeñaron estas mujeres en la guerra.
Proses Manufaktur Mesin Oven Kopi Tipe Tray Rotary Dengan Bahan Bakar LPG
Authors: Prastyo Ahmad Bagus , Kabib Masruki , Hudaya Akhmad Zidni
Published: July 2023

Mesin oven kopi adalah mesin tepat guna, dimana mesin ini berfungsi untuk mengeringkan kopi yang baru dipetik. Mesin oven ini banyak ditemukan di pasaran, akan tetapi masih banyak dari mesin yang berskala besar dan belum mengutamakan kualits produk kopi tersebut. Tujuam penelitian ini adalah membuat mesin oven kopi tipe tray rotary berkapasitas 25 kg dengan metode pengeringan menggunakan bahan bakar gas LPG Metode eksperimen pada pembuatan mesin oven kopi tipe tray rotari ini meliputi kajian pustaka, gambar kerja, perancangan manufaktur, proses manufaktur, dan kemudian dilakukan uji fungsional untuk menguji kapasitas mesin dan lama waktu yang dibutuhkan dalam proses pengovenan. Hasil penelitian ini pada  proses 5 jam pada temperature 45 ºC berat kopi 10 kg  terjadi penguapan/pengurangan kadar air dan berat kopi sebesar 3,76 kg, pada kapasitas 15 kg waktu proses 5 jam temperatur 50 ºC terjadi pengurangan massa kopi sebesar 5,58 kg dan pada kapasitas 25 kg waktu proses 5 jam temperatur 55 ºC terjadi pengurangan mssa kopi sebesar 10.6 kg.