bluuebunny/crossref_metadata_2025 huggingface dataset:
Library Carpentry: Towards a New Professional Dimension (Part III – Data Reconciliation, Named Entity Recognition and Advanced Utilities)
Authors: Mukhopadhyay Parthasarathi , Mitra Roshni
Published: June 2022

Data reconciliation and Named Entity Recognition (NER) are closely related concepts to the domain of data carpentry in general and library carpentry in particular. In this context, the part III of the three-part series on library carpentry (part I & II have been published in April & June issues of this journal) is an attempt to apply library carpentry methods in the core areas of information organization in a library of any type or size along with additional utilities like cross-linking of data sources, automatic translation, sentiment analysis and so on. A total of five case studies are included in this research study covering these areas with a focus on do-by-yourself mode.
Web-Based Ranking and Link Analysis of NAAC Accredited General Degree Colleges in West Bengal: A Webometric Study
Authors: Ghosh Sanjib , Roy Bijan Kumar
Published: June 2022

This study examines the websites of 36 NAAC-accredited general degree colleges in West Bengal using Webometric indicators. Webometric data is acquired on the Google search engine using special query syntax and calculated different WIFs and WISER value of websites, the relationship between the ranks of all websites as defined by WISER indexing value and in-link impact value are also examined. According to the findings, Panihati Mahavidyalaya's website under West Bengal State University ranked first in Simple Web Impact Factor (SWIF) with 1887.912%, and Banipur Mahila Mahavidyalaya's websites (Sl. No. 5) ranked first in self-link WIF, INLWIF, and EWIF with 0.679803 SLWIF, 0.729064 ELWIFs, and 0.315271 RWIFs, respectively. Darjeeling Govt. College is ranked first, followed by Panihati Mahavidyalaya and Mugberia Gangadhar Mahavidyalaya, according to the WISER index value. This study may aid college administrators and webmasters in better comprehending the importance of these websites in making them user-friendly and informative websites that meet the needs of their users.
Impact of Social Networking Tools on Undergraduate Students (Science Stream): An Analytical Study
Authors: Gupta Ekta , Gulati Anjali
Published: June 2022

Social Networking Sites (SNSs) have transformed the world by connecting people more than ever before. The present study seeks to examine the impact of social media on the overall development of undergraduate students enrolled in a reputed degree college based on a sample 112 students. Questionnaire method was used to collect data on the perceived usefulness and effectiveness of social networking tools among undergraduate science students. The study has also examined how social networking sites have influenced the academic and professional development of students. Additionally, the study has demonstrated the extent of involvement of students in the activities on SNSs and their purpose behind using SNSs. The researcher found these sites to be helpful for the students in improving their academic performance, preparing them for competitive exams, increasing their learning and research capabilities, and enhancing information technology skills.
Trend Analysis of Research Funded by Defence Research and Development Organisation
Authors: Chandra Ranadip
Published: June 2022

This study was carried out to investigate the trend of research funded by Defence Research and Development Organisation (DRDO) published between 2014 to 2018. Total 1569 articles published in 701 sources with an average 9.04 citations per document were found in Scopus database and downloaded in the BibTeX file format. Bibliometrix R Package was used to analyze different aspects of research. The study involved 3576 authors with 0.44 documents per author and 2.28 authors per document. The top 10 productive journals published 823 articles (52.45%). The journal RSC Advances published the highest number of articles. The top 10 productive authors published a total of 445 articles with 3836 received citations. Defence Metallurgical Research Laboratory collaborated with the highest number of research. Majority of the researches were carried out in India with collaboration with other countries, mainly from developed countries. The majority of the research was carried out under the subject microstructure, mechanical properties, X ray diffraction, optical properties, hypoxia, etc. This work may help DRDO to evaluate their criteria in funding research in future.
Learning Informally
Authors: Openjuru Ladaah Maxwell Godwin , Openjuru George Ladaah , Sanford Kathy , Jayme Bruno de Oliveira , Monk David
Published: June 2022

This paper advocates for the inclusion of the arts in vocational learning programs in Uganda, as an integrated form of holistic learning oriented towards empowerment and entrepreneurship. Using community-based research in the context of vocational education and training (VET), our data emerged from open-ended interviews, focus groups and youth-led radio talk shows with stakeholders from public and private sectors, instructors, artists, NGO’s. Three significant themes arose from the data collected. Firstly, the pathways available to learners to become artists are limited by neoliberal and technicist orientations towards education. Secondly, there are significant potential opportunities and interests. Secondly,  there is a thriving informal youth-led arts community in northern Uganda, which thirdly, without ways for learners to generate income, they are not able to devote their time to learning through the arts, and their artistic endeavours are not recognized as important skills in their communities or in society. We demonstrate that there is a vibrant space in the informal sector of arts, that if supported could become important and much needed sectors Uganda.
Storytelling to Preserve a Community’s History
Authors: Kemp Desmond , Rowley Latosha , Murphy Stacia
Published: June 2022

Storytelling has the power to send a message, preserve culture, history, and influence change. As CRISP Fellows, we visited long-term and new residents to capture their stories, memories, and reflections about the neighborhood history and the recent changes and trends that have impacted the Martindale Brightwood. As graduate students, we learned that community-based participatory research (CBPR) can teach students to make policy decisions that are sustainable and create academic research that is impactful.
Testimonios of (In)Justice and Communal Spaces
Authors: Sosa Teresa
Published: June 2022

In August 2020, four Latinas began their first year teaching and entered a school system that continues to emphasize policies, measures, and curriculum that supports racism and social injustice. Their first-hand experiences included a pandemic that largely challenged modes of delivery in schools and the lack of access for students of marginalized communities that made existing disparities even more obvious. But they also entered teaching at a time when there was renewed interest in openly pushing issues of race, oppression, and violence to the forefront. This article details how these four Latina teachers connected their testimonios to the currentsociopolitical realities and to their commitment to social change through monthly zoom chats. Their chats became spaces of Convivencia, a way to engage, reflect, and support each other that is centered within a Latina womanist epistemology. Cultural Intuition was used to analyze their experiences and to point out key aspects of their testimonios that reflect their ways of knowing and agency. This piece concludes by making a case for how these types of communal spaces are necessary across various institutions and spaces for Latinas.
Correlation between Internet Addiction Disorder and Mental Health of Junior Middle School Students in Chengdu
Authors: Zhang Jianxing , Zhang Suhua , Yao Xue , Zhang Li , Wu Dan , Chen Dongmei , Zhang Huabing , Ou Junli
Published: June 2022

Objective: To study the prevalence and main influencing factors of Internet addiction among junior middle school students in Chengdu, and to provide scientific basis for the prevention and intervention of Internet addiction. Methods: From September to December 2017, 3,607 junior middle school students were randomly selected from 8 middle schools in Chengdu by stratified cluster sampling, and investigated by selfmade questionnaire. SPSS 19.0 software was used for χ 2 test and multiple linear regression analysis. Results: 174 of 3,607 junior middle school students in Chengdu were diagnosed with Internet addiction, and the detection rate of Internet addiction was 4.8%. There were significant differences in the scores of mental health, learning pressure, parent-child relationship and peer relationship between Internet addiction and non-internet addiction junior middle school students (P < 0.05). The results of multiple linear regression showed that family economic status, learning pressure, depression and anxiety were positively correlated with internet addiction, while parent-child relationship, peer relationship and social support were negatively correlated with Internet addiction (P < 0.05, P < 0.01). Conclusion: The detection rate of Internet addiction among junior middle school students in Chengdu is at a low level. Junior middle school students with low social support and high depression and anxiety have a higher risk of Internet addiction, which can be reduced by improving their mental health.
Knowledge about glaucoma among patients attending the outpatient department of the department of ophthalmology of a tertiary care hospital
Authors: Raina Bhavani , Mahajan Sachit
Published: June 2022

Background: Glaucoma is the leading cause of irreversible blindness in the world. It is a noncommunicable chronic eye disease which needs lifelong care and treatment. Optic nerve damage is progressive and the disease mostly remains asymptomatic which makes it a public health challenge. Raising public awareness and knowledge about glaucoma is a key factor in early detection and management. The aim of the study was to assess knowledge about glaucoma among patients attending the eye outpatient department (OPD) of a tertiary care hospital.Methods: This study was conducted on 100 patients who attended the eye OPD of department of ophthalmology, Government Medical College (GMC), Jammu from December 2021 to May 2022. The study subjects were given a questionnaire and they had to respond to questions by choosing one of the three options.Results: In our study the mean age of patients was 50.65 years with majority of patients (50%) falling in the age group of 30 to 50 years. The male to female ratio was 1.7:1. Only 23% of the study subjects were knowledgeable about the fact that glaucoma was the most important cause of irreversible blindness. 83% of the respondents correctly identified people over 40 years of age at risk for developing glaucoma. Only 25% of the respondents identified pressure related damage to optic nerve as a feature of glaucoma. Majority of patients were unaware about asymptomatic nature of glaucoma. 93% of the study subjects considered glaucoma treatable. Only 23% had knowledge that irreversible loss of vision was the end result of glaucoma.Conclusions: This study showed that knowledge about glaucoma was limited in our part of the country. There is a need to increase awareness about the disease so that we can reduce the burden of glaucoma related blindness.
Encantada e o ABC do amor
Authors: Barbosa Karina Gomes
Published: June 2022

Resumo: O filme Encantada apresenta três tipos amorosos: o amor romântico, o amor cortês e o amor líquido. O artigo

pretende mostrar como a narrativa constrói as representações de cada um desses amores e o significado social do(s)

amor(es) no filme, a partir da análise dos personagens e das relações amorosas da obra.

Palavras-chave: cinema, filme de amor, narrativa cinematográfica, amor romântico.
Debord: espetáculo, fetichismo e abstratificação
Authors: Viana Nildo
Published: June 2022

Resumo: O presente artigo discute a obra de Guy Debord, analisando seus elementos fundamentais, seus limites e, ainda,

seu valor e atualidade. Para realizar esse objetivo, realiza uma análise da obra A Sociedade do Espetáculo e, após isto,

discute alguns limites, principalmente a abstratificação presente nela, elemento sem o qual uma justa avaliação seria

impossibilitada, inclusive perceber seu alcance atual e valor para entender a sociedade contemporânea.

Palavras-chave: Espetáculo, Debord, Abstratificação, Mercadoria, Fetichismo.
Espetacularização Midiática da Política
Authors: Barbosa Simonny Santos
Published: June 2022

O que se pode compreender por meio dos acontecimentos históricos no âmbito político é que espetacularização

sempre esteve relacionada a essa conjuntura. Esse é um cenário que sempre esteve permeado de políticos que utilizam

das representações para angariar votos e assim conquistar a eleição. Essa estratégia foi fortalecida principalmente com a

ambientação midiática, que exerce um papel essencial no cotidiano social, ainda mais, no atual momento, marcado pelo

capitalismo, em que a reprodução das imagens midiáticas e a publicidade possuem alto poder de manipulação sobre

os receptores.

Palavras-chave: Espetacularização. Mídia. Política.
Em Busca da Identidade Perdida
Authors: Prado Luiz Serenini
Published: June 2022

Resumo: Este artigo propõe uma discussão sobre o fenômeno relacionado com a crise de identidades provocada

pelo advento das novas tecnologias e tudo que isso pode acarretar em relação à comunicação das

empresas com seus públicos, particularmente os situados entre os 8 e 14 anos.

Palavras - chave: Identidade, cultura, pós-modernidade
Contribuições das Tecnologias da Informação e Comunicação no Processo Ensino-Aprendizagem
Authors: Silva Lindinalva Gomes da , Prado Luiz Serenini
Published: June 2022

RESUMO: Este artigo visa discutir como as novas tecnologias vêm atuando no cotidiano, causando mudanças sociais e

culturais e transformando comportamentos. O momento atual requer atenção diferenciada para a Educação

numa perspectiva de trazer, para o ambiente escolar, recursos que contribuam para uma pedagogia apropriada

que deverá atender os nativos digitais, falantes oriundos da linguagem digital dos computadores, vídeo

games e internet.

PALAVRAS-CHAVE: Comunicação. Novas tecnologias. Formação docente.
Mídias Sociais e as Transformações na Relação de Consumo
Authors: Toledo Arthur Chaves , Nalini Lauro Eugênio Guimarães
Published: June 2022

RESUMO: As mídias sociais tornaram possível a conexão de indivíduos e o intercâmbio de informações pelo globo.

A visibilidade proporcionada pela web atua na defesa de direitos do cidadão e expõe às instituições públicas

e privadas os seus problemas, os efeitos de suas ações e a necessidade de melhorar a suas atitudes

e posicionamento.

PALAVRAS-CHAVE: Internet, cidadão, redes sociais, mídias sociais, consumo, cibercultura.
Avaliação de Ações de Programas de Comunicação Interna em Trabalhos Apresentados no Intercom 2011
Authors: Barros Rodrigo De , Andrada Renata Borges Crispim
Published: June 2022

RESUMO: A avaliação em comunicação no âmbito organizacional ganhou relevo a partir dos anos 2000. Dada sua importância,

neste artigo são apresentados modelos e categorias de avaliação da comunicação organizacional

e é realizada a análise de ações de programas de comunicação interna presentes em trabalhos apresentados

no XXXIV Intercom, realizado em 2011.

PALAVRAS-CHAVE: Comunicação Organizacional. Comunicação Interna. Avaliação em Comunicação Organizacional.
Redes Sociais e Consumo de Notícias
Authors: Farias Aline Bouhid Camargo de
Published: June 2022

RESUMO: O estudo propõe discutir a influência que redes sociais têm sobre o consumo de notícias. Para isso, fizemos

pesquisa exploratória comparativa e estudamos autores da área comportamental e da sociologia estrutural.

Os resultados deste estudo limitam-se a verificar a relação entre a influência das redes sociais e o consumo

de notícias.

PALAVRAS-CHAVE: Notícias. Comportamento. Consumo. Redes sociais.
Facebook como Ferramenta Estratégica na Campanha da OAB-GO 2012
Authors: Marinho Sueda Dos Santos , Ferreira Adriana Rodrigues
Published: June 2022

RESUMO: Este artigo apresenta, a partir de um estudo de caso, as contribuições do uso da ferramenta Facebook dentro

de um grupo delimitado de tempo e trabalho, a campanha para presidência da OAB-GO de 2012, promovida

pela chapa 1 OAB FORTE E RESPEITADA entre os meses de setembro e novembro. Acredita-se que através

da rede social alguns personagens ocupam posições estratégicas para a disseminação da informação, conferindo-

lhes credibilidade, e por meio do estudo deste caso será verificado como se deu o fluxo de informações

nesta rede e o quanto foi importante como promotor de repercussão dentro da campanha.

PALAVRAS-CHAVE: OAB. Redes sociais. Informação. Comunicação. Facebook
A Visbilidade e a Difusão da Arte por Meio das Redes Sociais - estudo de caso da Fan page "Eu me Chamo Antônio"
Authors: Brito Deiga Luane Borges de , Rocha Cláudio Aleixo
Published: June 2022

RESUMO: A proposta do artigo é investigar como artistas anônimos conquistam reconhecimento e reputação simbólica

nos sites de redes sociais, por meio do estudo de caso da fan page ??Eu me chamo Antônio?. Para tanto, foram

exploradas as temáticas que envolvem a comunicação no ciberespaço através de pesquisa bibliográfica.

Apresentam-se os conceitos: cibercultura, comunidades virtuais, inteligência coletiva, redes sociais e capital

social relacionando-os com objeto de estudo principal: a arte.

PALAVRAS-CHAVE: Arte. Cibercultura. Ciberarte. Redes sociais. Capital social.
As Redes Sociais e os Protestos de Rua no Brasil em 2013: um panorama da sociedade em rede
Authors: Santos Jonathan Jayme dos , Rocha Cláudio Aleixo
Published: June 2022

RESUMO: Este trabalho analisa, a partir da revisão de conteúdos já publicados, o retrato que se formou nas sociedades

material e virtual no Brasil no ano de 2013, quando uma onda de protestos aconteceu em todo território

nacional; percebe a construção de ações reais e as interações das chamadas sociedades em redes virtuais;

relaciona os protestos de rua à teoria das comunidades virtuais a partir da busca de seus personagens pelos

mesmos valores e interesses.

PALAVRAS-CHAVE: Sociedade em rede; Protestos; Redes sociais; Comunidades
O Uso das Redes Sociais como Meio de Mobilização Social nos Protestos Nacionais de Junho de 2013
Authors: Tavares Viviany Rodrigues de Souza , Barbosa Bruno Dos Reis , Santos Flávia Martins dos
Published: June 2022

RESUMO: Este artigo trata de como o ciberespaço tem sido utilizado pela sociedade com o propósito de mobilizar os

usuários das redes sociais em razão do que se objetiva, com uso de argumentação pertinente que é capaz

de engajar o usuário através da formação de opinião pública. O trabalho se constrói com base no estudo

da cibercultura, da mobilização social, da teoria do Espiral do Silêncio e do uso do Facebook e do Twitter

como plataformas-base de sociabilidade online. Além disso, foram analisadas por meio de observação

participante a repercussão ?? nestas plataformas ?? dos movimentos populares ocorridos no Brasil nos dias

18 e 20 de junho de 2013, em decorrência do aumento do valor da passagem, da votação do PEC 37, dos

gastos com a Copa do Mundo e da corrupção política.

PALAVRAS-CHAVE: cibercultura, opinião pública, espiral do silêncio, redes sociais, mobilização social.
Prática de Jornalismo e sua Interferência nos Direitos Humanos
Authors: Costa Ana Manuela Arantes
Published: June 2022

RESUMO: Este artigo propõe a reflexão sobre como práticas de jornalismo, essencialmente na televisão, podem ser

ou não incentivadoras e realizadoras de ações que promovam a defesa dos direitos humanos. Para isso,

serão abordados resultados de pesquisas bibliográficas sobre noções de direitos humanos e de critérios

de noticiabilidade, além da análise de reportagens exibidas no telejornal JA 2ª edição, da TV Anhanguera,

filiada da Rede Globo, sobre manifestações ocorridas em Goiânia (GO) contra o aumento da tarifa da

passagem de ônibus.

PALAVRAS-CHAVE: Direitos humanos; jornalismo; noticiabilidade; JA 2ª edição.
Cross-country comparison of health policies in eight countries
Authors: Gupta Rajendra Pratap , Sodani Prahlad Rai
Published: June 2022

The primary objective of this paper is the comparison and describe features of health policies across the selected countries viz, Argentina, Australia, Finland, Kenya, India, South Korea, United Kingdom (U.K), United States (U.S). The second objective of the paper is to understand the political commitment in each country by comparing the allocation of adequate resources toward health.

To study health policies, eight countries are selected from each geographical region and to determine political commitment toward health policy, three related variables are analyzed. Databases of the multilateral organization including the World Health Organization (WHO) are searched for the latest data.

Out of the eight countries studied, only India and Kenya have a National Health Policy. The rest of the countries have medical care policies or health insurance policies or national law to lay down the vision for the health sector.

The data indicate that countries which fall in the higher income bracket spend more on health. However, the spending data or the lack of it indicates that there is perhaps no focus on primary care, nutrition, and sanitation, among the prominent drivers of health outcomes.

Many countries continue to struggle, to maintain continuity in the broad direction of the health policy. The realm of health process formulation is a major area which needs further research, evidence, re-orientation, and training for policymakers across countries to ensure structured and evidence-based policy formulation. Once there is a structured health policy process, the health policies may effectively address the ground-level issues and may lead to better health outcomes.
Defesas On-line de Monografia de Licenciatura em Ciências Biológicas do EaD IBRAG/UERJ em Tempos de Pandemia da COVID-19
Authors: Vasconcelos Mariana Castro de , Lacerda Luiz Eduardo Macedo de , Souza Karine Pereira Albuquerque de , Santos Sonia Barbosa dos
Published: June 2022

O Curso de Ciências Biológicas da Universidade do Estado do Rio de Janeiro (UERJ), na modalidade de Ensino a Distância (EaD), possui na grade curricular atualmente as disciplinas de Projeto Final (currículo antigo) e Trabalho de Conclusão de Curso 2 (currículo novo). Como produto final dessas disciplinas, os alunos devem desenvolver uma monografia e apresentá-la através de uma defesa pública. Contudo, devido ao afastamento social imposto pela pandemia da COVID-19, as defesas públicas presenciais ainda não são recomendadas, pois geram aglomerações que facilitam a transmissão e contágio do vírus. O objetivo deste trabalho foi discutir as percepções dos discentes (concluintes) e docentes (orientadores) a respeito das defesas on-line, registrando as adaptações realizadas em ambas as disciplinas. Para isso utilizamos as informações obtidas durante as etapas da defesa e realizamos um levantamento de dados a partir de dois questionários elaborados pelo Google Forms, destinados aos orientadores e discentes do curso de Licenciatura em Ciências Biológicas a distância da UERJ. Foram realizadas 20 defesas públicas on-line, utilizando Tecnologia de Informação e Comunicação (TIC), como webconferências e formulários eletrônicos. A plataforma mais utilizada nas defesas foi o Google Meet e a maioria dos entrevistados aprovou essa mudança. Por isso, sugere-se que os discentes e seus orientadores possam optar pela defesa presencial ou on-line após o fim da pandemia. A partir dessa nova experiência notamos a necessidade de um ambiente virtual padronizado e institucional para defesa pública, que permita o acesso aberto para qualquer público que deseje participar.
Monkeypox Outbreaks in Non-Endemic Countries: What Do We Know and What Do We Need?
Authors: Shamabadi Ahmad , Akhondzadeh Shahin
Published: June 2022

The Article Abstract is not available.
Expression of Toll-Like Receptors 2, 4 and 5 in Relation to Gut Microbiota in Colon Neoplasm Patients with and without Inflammatory Bowel Disease
Authors: Asadzadeh Aghdaei Hamid , Rezasoltani Sama , Olfatifar Meisam , Nazemalhosseini Mojarad Ehsan , Sherkat Ghazal , Yadegar Abbas , Feizabadi Mohammad Mehdi , Zali Mohammad Reza
Published: June 2022

Background: Toll-Like Receptors (TLRs) are the critical mediators of inflammatory routs in the gut, which play an essential role in regulating the immune responses towards various ligands derived from pathogenic bacteria. Also, TLR signaling has been implicated in the development of Inflammatory Bowel Disease (IBD), Adenomatous Polyp (AP), and Colorectal Cancer (CRC). Here, we aimed to examine the expression of some TLRs concerning certain fecal bacteria in AP and CRC patients with and without IBD.
Methods: This case-control study collected fecal and colonic tissue samples from 93 patients versus Normal Controls (NC) via colonoscopy. Fecal samples were used for DNA extraction, and the abundance of selected fecal bacteria was determined by absolute real-time PCR. Also, the gene expression of TLR2, 4, and 5 was analyzed using RT-PCR on the colonic tissues of participants.
Results: Compared to NC individuals, in AP and CRC patients, the mRNA expressions of TLR4 and TLR2 were significantly increased while TLR5 was decreased. A meaningful association between TLRs mRNA expression levels and the abundance of some selected fecal bacteria was detected. Also, there was a significant relationship between participant’s food regimes, smoking habit and intestinal TLRs expression.
Conclusion: Our study proposed the important role of TLRs during adenomatous and CRC formation. Alterations in TLRs expression associated with certain gut bacteria may contribute to disease development.
An in silico Design, Expression and Purification of a Chimeric Protein as an Immunogen Candidate Consisting of IpaD, StxB, and TolC Proteins from Shigella spp
Authors: Fathi Javad , Nazarian Shahram , Kordbacheh Emad , Hadi Nahal
Published: June 2022

Background: Shigella spp. is the cause of dysentery and is widespread worldwide. On the other hand, antibiotic resistance is increasing in this bacterium. Bioinformatics is a new approach to vaccine and drug design involving the selection of appropriate antigens. This study aimed to design a chimeric protein consisting of IpaD, StxB, and TolC proteins from Shigella through a bioinformatics approach as an immunogen candidate.
Methods: The sequences of ipaD, stxB, and tolC genes were obtained. Additionally, the immunogenic regions of the associated protein, physicochemical characteristics, protein structures, B and T cells epitopes, and molecular docking were determined using in silico servers. Besides, the chimeric gene was synthesized following sequence optimization by utilizing the codon usage of Escherichia coli (E. coli). The expression of the recombinant protein was confirmed via SDS-PAGE and Western blot technique.
Results: The residues 41-160 of IpaD, 21-89 of StxB, and 40-335 of TolC were selected. According to half-life, instability, and buried indices, IpaD-StxB-TolC was selected as the best arrangement. The Ramachandran plot showed that 97.077% of the amino acids were in the favored area. Linear and conformational epitopes were also present throughout the chimeric protein sequence. Moreover, the C-ImmSim server indicated that IgG and IgM titers could reach desirable values by the third injection. Furthermore, the stability of the mRNA-optimized gene was enhanced, increasing the Codon Adaptive Index (CAI) to 0.9. Finally, the chimeric gene was transferred to E. coli BL21, and the expression of the 60.6 kDa recombinant protein was confirmed. 
Conclusion: The results indicated that the recombinant protein could act as a proper immunogen candidate against Shigella spp.
Neutrophil to Lymphocyte Ratio (NLR) and Derived NLR Combination: A Cost-effective Predictor of Moderate to Severe COVID-19 Progression
Authors: Kaboudanian Ardestani Sussan , Salehi Mohammad Reza , Attaran Bahareh , Hashemi Seyed Mahmoud , Sadeghi Somayeh , Ghaffarpour Sara , Tuserkani Fatemeh , Ghazanfari Tooba
Published: June 2022

Inflammation is an essential contributor to Coronavirus disease 2019 (COVID-19).  In this regard, finding a prognostic indicator is valuable because the treatment will be more effective if critical patients with high inflammation are diagnosed earlier. We aimed to evaluate some hematologic markers for COVID-19 and assess their association with the severity of the disease.
A total of 154 COVID-19 patients were laboratory-confirmed and admitted to Imam Khomeini Hospital Complex, Tehran, Iran, from February 12, 2020, to April 4, 2020, and 55 healthy individuals were enrolled in the study. The severity of the patients' illnesses was classified into three subgroups according to the types of oxygen therapies (moderate (61), severe (28), and critical (43)) and examined the different ratios of total white blood cell (WBC) count, neutrophil to lymphocyte ratio (NLR), platelet to monocyte ratio (PLR), macrophage to lymphocyte ratio (MLR), derived NLR ratio (dNLR), and some biochemical tests.
COVID-19 patients had higher levels of NLR, MLR, PLR, and dNLR than healthy subjects. receiver operating characteristic (ROC) analysis of the curve revealed that NLR and dNLR had a high diagnostic value to differentiate COVID-19 patients from healthy subjects (area under the curve [AUC]=0.923 and 0.910, respectively) and predict mortality (AUC=0.726 and 0.735, respectively).
NLR and dNLR may be reliable markers to evaluate the severity of COVID-19. NLR and dNLR had a high diagnostic value for differentiating COVID-19 patients from healthy subjects, and they could predict the severity and outcome of the disease.
Induced Pluripotent Stem-cells Inhibit Experimental Bleomycin-induced Pulmonary Fibrosis Through Regulation of the Insulin-like Growth Factor Signaling
Authors: Bayati Paria , Taherian Marjan , Assarehzadegan Mohammad-Ali , Soleimani Mansoureh , Poormoghim Hadi , Mojtabavi Nazanin
Published: June 2022

Idiopathic pulmonary fibrosis (IPF) is among the illnesses with a high mortality rate, yet no specific cause has been identified; as a result, successful treatment has not been achieved. Among the novel approaches for treating such hard-to-cure diseases are induced pluripotent stem cells (IPSCs). Some studies have shown these cells’ potential in treating IPF. Therefore, we aimed to investigate the impact of IPSCs on insulin-like growth factor (Igf) signaling as a major contributor to IPF pathogenesis.  
C57BL/6 mice were intratracheally instilled with Bleomycin (BLM) or phosphate-buffered saline; the next day, half of the bleomycin group received IPSCs through tail vein injection. Hydroxyproline assay and histologic examinations have been performed to assess lung fibrosis. The gene expression was evaluated using specific primers for Igf-1, Igf-2, and insulin receptor substrate 1 (Irs-1) genes and SYBR green qPCR master mix. The data have been analyzed using the 2-ΔΔCT method.
The mice that received Bleomycin showed histological characteristics of the fibrotic lung injury, which was significantly ameliorated after treatment with IPSCs comparable to the control group. Furthermore, gene expression analyses revealed that in the BLM group, Igf1, Igf2, and Irs1 genes were significantly upregulated, which were returned to near-normal levels after treatment with IPSCs.
IPSCs could modulate the bleomycin-induced upregulation of Igf1, Igf2, and Irs1 genes. This finding reveals a new aspect of the therapeutic impact of the IPSCs on IPF, which could be translated into other fibrotic disorders.
Wharton's Jelly Mesenchymal Stem Cells-derived Exosomes and Imipenem in Combination Reduce Apoptosis and Inflammatory Responses in E.coli-infected HepG2 Cells
Authors: Hazrati Ali , Soudi Sara , Hashemi Seyed Mahmoud
Published: June 2022

Antibiotics are used to treat bacterial liver infections and the resulting inflammation. However, their use is limited due to their side effects, especially the development of antibiotic resistance.
Mesenchymal stem cells (MSCs) are recognized for their immunomodulatory properties. In this study, we investigated the immunomodulatory effect of Wharton's jelly MSC-derived exosomes in combination with imipenem on HepG2 cells infected with Escherichia coli.
MSC-derived exosomes were separated from MSCs, which were isolated by flow cytometry. Scanning electron microscopy and dynamic light scanning were used to confirm the presence of exosomes. Quantitative real-time PCR, ELISA, and nitric oxide assay were used to assess the inflammatory response in the infected cells. Annexin-PI was used to measure the extent of apoptosis.
The results showed that the combination of imipenem and MSC-derived exosomes were more effective than imipenem or exosomes alone in reducing the production and secretion of inflammatory cytokines, nitric oxide, and apoptotic rate in E Coli-infected HepG2 cells.
Eugenol: A New Option in Combination Therapy with Sorafenib for the Treatment of Undifferentiated Thyroid Cancer
Authors: Talezadeh Shirazi Pedram , Farjadian Shirin , Dabbaghmanesh Mohammad Hossein , Jonaidi Hossein , Alavianmehr Ali , Kalani Mehdi , Emadi Ladan
Published: June 2022

Thyroid cancer (TC) is the most common endocrine malignancy. Thyroidectomy and radiotherapy are common treatment modalities for patients with undifferentiated TC (UTC), and sorafenib is usually recommended to prevent a recurrence. However, malignant cells may evade chemotherapy-induced apoptosis, and combination therapy was developed to achieve better outcomes. This study investigated whether eugenol in combination with sorafenib was more effective than either substance individually in triggering apoptosis in the UTC.
The IC50 of sorafenib and eugenol was determined in a UTC cell line (8305C) by MTT assay, and their synergistic effect in combination therapy was investigated. Flow cytometry was used to evaluate the rate of apoptosis in treated cells. To confirm that cell death occurred through apoptosis, immunoblotting was used to determine the relative cleavage of caspase-8 and caspase-9.
The IC50 of sorafenib was 20 µM, and that of eugenol was 2100 µM. The sorafenib-eugenol combination (1:105) showed synergistic effects at concentrations equal to or less than their IC50. The rate of apoptosis induction was higher in cells treated with eugenol or the eugenol-sorafenib combination compared to sorafenib-treated cells. The relative intensity of cleaved/uncleaved forms of caspase-8 increased in eugenol-treated cells compared to sorafenib-treated cells.
Sorafenib and eugenol at concentrations equal to or less than their IC50 had a synergistic effect in 8305C cells. The most potent apoptotic effect was achieved with sorafenib and eugenol at their IC50. Lower doses of sorafenib could be used with eugenol to improve its efficacy while reducing its side effects.
Clinical and Molecular Assessment of Iranian Families with Severe Congenital Neutropenia, Identification of HYOU1 and SHOC2 as Potential Novel Gene Defects
Authors: Arab Fatemeh , Rezaei Nima , Taheri Forough , Kouhpeikar Hamideh , Rayzan Elham , Mirbeyk Mona , Zare‐Abdollahi Davood , Ghadami Mohsen
Published: June 2022

Neutropenia congenita grave (SCN) is a rare disease with a genetically and clinically heterogeneous nature, usually diagnosed in childhood, with an elevated risk of infections such as otitis, skin infections, pneumonia, deep abscesses, and septicemia. Patients with SCN also have an increased risk of leukemia, and mutations in the ELANE and the HAX1 genes have been observed in those patients.  
This study was conducted to genetically screen six Iranian families with SCN who have at least one affected person. In the first step, all exons and intron boundaries of ELANE and HAX1 genes were sequenced in probands. Cases with no pathogenic mutations were tested through whole-exome sequencing (WES).
Analysis showed five different variants in ELANE (c.377 C>T), HAX1 (c.130_131 insA), HYOU1 (c.69 G>C and c.2744 G>A) and SHOC2 (c.4 A>G) genes in four families. We found that two out of six families had mutations in ELANE and HAX1 genes. Moreover, we found
two novel mutations at the HYOU1 gene that had not previously been reported, as well as a pathogenic mutation at SHOC2 with multiple phenotypes, that will contribute to determining the genetic basis for SCN.
Our study revealed that WES could help diagnose SCN, improve the classification of neutropenia, and rule out other immunodeficiencies such as autoimmune neutropenia, primary immunodeficiency diseases, and inherited bone marrow failure syndromes.
A Review on Important Zoonotic Bacterial Tick-Borne Diseases in the Eastern Mediterranean Region
Authors: Yousefi Behzadi Manijeh , Mostafavi Ehsan , Rohani Mahdi , Mohamadi Ali , Ahmadinezhad Mozhgan , Moazzezy Neda , Shams-Ghahfarokhi Masoomeh , Razzaghi-Abyaneh Mehdi
Published: June 2022

Background: Zoonotic diseases as health concerns worldwide account for more than half of the emerging infectious diseases. Arachnids are powerful vectors to transmit several diseases to humans. Additionally, these emerging zoonotic diseases have been a considerable health threat in the Eastern Mediterranean Region of the WHO (EMRO) due to the large population living close to farms and international trade with nearby countries.
Methods: This review study is based on the reported three tick-borne diseases, Lyme disease, Tularemia, and Q fever, from Iran and other EMRO countries. To this end, we searched PubMed central, ISI web of Science, and Google with the related keywords in English at any time. The reported data are then sorted by countries for each disease.
Results: According to the published data, 15 countries in the region have one/more emerging infectious diseases. Q fever has been the most frequent infection in EMRO countries, while Lyme was less recorded. Furthermore, Iran is among the countries with documented history of all three investigated diseases.
Conclusion: Tick-borne disease is popular among EMRO countries, indicating that they have natural conditions for infections in animals and humans. It appears necessary to develop a disease management strategy and control programs against tick-borne diseases (TBDs). Moreover, the disease-resistant animal could be bred instead of susceptible livestock. Therefore, research studies to control TBDs should be regarded as a top priority plan.
Evaluation of Efficiency of Ivermectin Lotion in Comparison with Permethrin Shampoo and Dimethicone Lotion for Treatment of Head Lice (Pediculus humanus capitis) in Areas Covered by Health Centers of Islamshahr City, Tehran, Iran in 2019
Authors: Hamedanian Leila , Salmani Nadoshan Mohammad Reza , Vatandoost Hassan , Baniardalani Mojgan , Rafinejad Javad
Published: June 2022

Background: Head lice infestation is known as a serious health problem in developing and developed countries. The prevalence of pediculosis in children and females is higher than others. The infestation may cause the absence of student from school and make their parents upset. The aim of current study was to evaluate the WHO recommended insecticides for control of head lice in Islamshahr health center.
Methods: In the current study infested individuals were older than 6 years old and have been diagnosed with at least 3 head lice adult and 10 live nits from less than 0.7 cm scalp. The pediculicides was applied randomly among groups. Permethrin shampoo as a golden standard was used. Dimethicone lotion 4% and Ivermectin lotion was compared with it. This study was conducted on 179 infested people. Results of infestation were evaluated after one month of intervention. Different indicators such as: present of head lice adult or live nit, redness and irritation in head skin were invested.
Results: All the participants were female and 72.6% of them were in the age group of 6-11. The result revealed that aging not only decreases the infection rate but also raised the recovery percentage. The results showed that 79.5% permethrin receiver, 83% of people who treated with Dimethicone lotion and 90.6% of Ivermectin receiver had no head lice. There was no significant difference among these three pediculicides.
Conclusion: There was no significant difference among tested pediculicides. An appropriate pediculicide can be selected by training people.
Exploring the Shared Knowledge Repositories Program to Reduce International Credit Transfer (ICT) Students' Academic Stress
Authors: Aprianti Fitri , Maulana Muhammad Azka
Published: June 2022

Exposed to a completely different learning environment, international credit transfer students tend to experience severe symptoms of academic stress. Moreover, the lack of research and treatment related to students’ academic stress-coping makes it difficult to measure their stress levels. This article reports on a study that explored the use of shared knowledge repositories to reduce the exchange students’ symptoms of academic stress. Data were collected using a quantitative method in naturalistic settings of three departments at one of the universities that followed the international credit transfer program to Taiwan and India. An inventory test was accordingly adapted to measure changes in the participants after a shared knowledge repositories program was conducted. A total of 20 ICT students from two groups were selected as the sample for the research. Findings were gathered through document analysis, followed by an inventory t-test to investigate changes in the participants after the sharing session program. In this case, the results of the t-test and document analysis suggested that an improvement was seen in the degree of students’ stress coping system. The results indicated that the program requirements for the participant to constantly create and share learning resources and strategies might have reduced students’ stress related to academic expectations and examinations. Besides, the stage of observation and reflection might have contributed to students’ ability to cope with stress in academic self-perceptions.
Keywords: shared knowledge repositories program, ICT students, academic stress
Building a Strong Partnership with International Partner Institutions
Authors: Sahroni Imam
Published: June 2022

The three stages for building a solid partnership between international partner universities are collaboration management, development program, and strengthening. Collaboration management is needed to tie the partnership between universities. Since the partner universities may have different time zones and cultures, good collaboration is needed. The partnership can be secured by developing programs for its effective implementation. The program can be academic such as student exchange, joint degree, faculty exchange, joint research and publication, international conference, and visiting scholars programs. To have a solid partnership, each university must run the program together. Programs with three or more partners can form a consortium. The consortium in turn can help each university strengthen its collaboration, increase the university ranking, and develop more benefit programs.
Keywords: collaboration management, development program, solid partnerships
Integrating Community Partnership Program in Cengkeh Afo: A Community-based Tourist Attraction
Authors: Aboe Roswita M.
Published: June 2022

Cengkeh Afo, a spice-based tourist attraction in North Maluku, is situated in the forest area behind Mount Gamalama. It has the potential to attract both domestic and international tourists through community-based tourism (CBT). The area is managed by the Cengkeh Afo Gamalama Spices (CAGS) community that uses the world’s oldest clove spot as an icon for the Spice Island. The community partnership program (PKM) has been integrated in response to the COVID-19 pandemic, which has had a wide impact on business and tourism. The PKM was integrated to build collaboration among the community for building the CAGS management capacity. Mastering basic English, managing data on tourist visits, utilizing local wisdom related to traditional gastronomy (local cuisine), mastering technology in managing tourism promotion, and understanding the application of the CHSE health protocol in tourism services in the region are among PKM’s goals for partnerships with the CAGS community. The qualitative approach was used in this research. Data were gathered through observation, questionnaires, and interviews in a field survey. The results showed that by working together the CAGS community has met the criteria for communitybased tourism service. Collaboration with research counterparts has aided the CAGS community’s capacity-building in its service.
Keywords: Cengkeh Afo, community-based tourism, capacity-building
Indonesian Cultural Representation in Universitas Islam Indonesia (UII) Virtual Exchange Programs
Authors: Gailea Ginanjar
Published: June 2022

The virtual exchange program is one of the media used to facilitate cross-cultural understanding among students in a time when physical encounters cannot take place. The program invited participants to acknowledge multiculturalism and generate respect and empathy among various collective identities. Drawing on the Stuart Hall’s theory of representation, this study examines and analyzes the cultural elements displayed during a series of virtual exchange programs held in 2021. Specifically, it discusses the representation issues related to Indonesian cultures discovered during the virtual cultural exchange programs administered by the Directorate of Partnership/Office of International Affairs Universitas Islam Indonesia (UII) Yogyakarta during the COVID-19 pandemic. The study revealed that the representation of Indonesian cultures in the programs was partial and Java-centric. The depiction of Indonesian cultures through visual and audiovisual tools was dominated by the elements derived from Javanese culture and tradition. Hopefully, this study can enrich the ongoing academic conversations on Indonesian cultural representation in the age of new media.
Keywords: Indonesia, cultural representation, virtual exchange