bluuebunny/crossref_metadata_2025 huggingface dataset:
“SO FUCKING CUTE IM DYING”: The use of hyperbole on X
Authors: Benammar Silya
Published: June 2024

This paper examines the use of hyperbole on the social media platform X, from a corpus of 1000 tweets collected between 2021 and early 2023. Keeping in mind the different ways in which hyperbole can be used, and how it differs from Extreme Case Formulation (Pomerantz 1986), verbal (Claridge 2011) and visual instances (Callister & Stern 2007) will be studied, showing that people have adapted to the lack of paralinguistic cues online, and have found new ways of expressing themselves.
« Prendre a cup of tea », ou une tasse de thé ? Une approche sociostylistique des altérismes
Authors: Cazé Alexandre
Published: June 2024

Loin de répondre seulement à des besoins dénotatifs, l’introduction d’altérismes (en particulier ici d’anglicismes et de gallicismes) transmet un faisceau d’informations englobant des connotations, l’appartenance à un groupe social ou une image de l’énonciateur. Le phénomène d’altérisme (terme que l’on préférera à celui d’« emprunt » et qu’on définira comme modification d’une langue sous l’influence d’une autre langue étrangère) donne ainsi à voir le feuilletage de significations sociales inscrites dans des choix énonciatifs. On propose ici une approche sociostylistique des altérismes, qui sera appliquée à trois textes littéraires de Nabokov, Capote et Proust.
Fractal narratives and musical transmission: the case of Nancy Huston
Authors: Mole Christopher
Published: June 2024

This article focuses on the narrative complexity in Nancy Huston’s novels. This is because Huston’s writing seems to showcase overlapping, interconnected, and perhaps never-ending relationships between and within her literary texts. This reflects the self-similarity of fractal shapes in the natural world. Crucially, if one were to zoom on to a small piece of fractal, the result would very much like the original (larger) entity. In a literary context, narratives as fractals are a “self-symmetry”; in the case of Huston’s texts, they are the (re)transmission of themselves, (re)fracted in different languages, both verbal and musical. In the first instance, this study focuses on Huston’s mise-en-abyme of the writing process, taking examples from the author’s novels since the 1990s. I will then analyse how Huston makes use of intermedial forms, such as musico-literary texts, in order to reinforce the self-reflexive dimension of the texts – attention will be paid to her first novel Les Variations Goldberg (1981) and her self-translation The Goldberg Variations (1996).
Des amphores de l’oppidum de Châteaumeillant (Cher) : le matériel des fouilles des xixe et xxe s.
Authors: Laubenheimer Fanette , Barthélemy-Sylvand Céline
Published: June 2024

Châteaumeillant est bien connu pour ses « caves ou fosses à amphores » découvertes au cours des xixe et xxe s. L’historique des découvertes et l’analyse de ce que l’on connaît des dépôts d’amphores conduisent à l’étude détaillée du matériel conservé au musée Émile-Chénon. Amphores gréco-italiques et Dressel 1 majoritairement (plusieurs centaines), le plus souvent entières, fournissent des données précieuses pour la typologie, le volume et le poids des conteneurs, comme le catalogue des timbres et des marques peintes. Il en ressort des indications chronologiques qui faisaient cruellement défaut jusque-là, une réflexion sur les dépôts d’amphores et une vue sur l’origine et les circuits d’importation des vins dans cet oppidum puissant à la fin de l’âge du Fer.
Taiwanese Dermatological Association consensus recommendations for the diagnosis, treatment, and management of generalized pustular psoriasis
Authors: Hsu Chao-Kai , Huang Yu-Huei , Chang Chung-Hsing , Chen Yi-Ju , Chiu Tsu-Man , Chung Wen-Hung , Jang Chiau-Sheng , Lin Shang-Hung , Lu Chun-Wei , Wu Nan-Lin , Yu Sebastian , Tsai Tsen-Fang
Published: June 2024

Generalized pustular psoriasis (GPP) is a rare, potentially life-threatening skin disease characterized by relapsing and remitting flares of sterile neutrophilic pustules and systemic inflammation. The definition of GPP is inconsistent globally, with large discrepancies in clinical management. To provide clinical guidance on managing GPP, we conducted a systematic literature search for articles published within the last decade on PubMed and the Cochrane Library in October 2022 and held four consensus meetings with 12 Taiwanese dermatologists between October 2022 and July 2023. Upon review of 153 articles, we agreed to adopt the European Rare and Severe Psoriasis Expert Network GPP definition with additional clarifications on pustular flares in psoriatic plaques, circinate or annular lesions, and localized pustules. We also drafted a diagnostic algorithm to facilitate GPP diagnosis. Twenty-seven statements on GPP treatment reached consensus. We recommend using an oral retinoid or spesolimab injection for the first-line treatment in both acute (treating flares) and maintenance (preventing flares) settings in adults with GPP. For infants and juveniles with GPP, retinoids are recommended as a first-line treatment. Evidence for other conventional and investigational therapies was reviewed, and a treatment algorithm was proposed. We hope this consensus provides practical guidance for clinicians in Taiwan and helps improve outcomes for GPP patients.
Evaluation of bone apposition on surface modified titanium implant in experimental animal model: A systematic review and meta-analysis
Authors: Saini Priya , Sood Shaveta , Chahal Gurparkash Singh , Jain Ashish
Published: June 2024

Purpose:

To evaluate the response of peri-implant bone to smooth (machined) surface and surface-modified dental implants in healthy experimental animal models.

Materials and Methods:

Systematic electronic search was done for using PUBMED, SCOPUS, WEB OF SCIENCE, and EMBASE databases for potentially relevant records from the last 20 years. Duplicate screening and data extraction were performed to formulate the evidence tables and meta-analysis following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. The outcome criteria were: 1. Bone Implant Contact (BIC) in percentage, 2. Removal Torque Values (RTV) in Ncm, 3. Implant stability Quotient (ISQ), Quality assessment was done using the ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines and SYRCLE RoB (Systematic Review Centre for Laboratory Animal Experimentation Risk of Bias) tool.

Results:

Results were expressed as pooled mean difference for the respective groups viz. sandblasted and acid etched, laser modified, acid etched and anodized surface. The surface modified implants revealed somewhat higher BIC over machined surface (P < 0.01). Forest plot were drawn for all the outcome variables.

Conclusions:

Within the limitations of this study, the authors found a higher degree of osseointegration pertaining to bone to implant interface, RTV, and implant stability quotient (ISQ) with surface modified procedures which seemed to promote bone formation around peri-implant tissue during the early stages of healing. After analyzing all 37 included publications for the outcome of interest (BIC%, RTV, ISQ), a positive outcome was obtained for both subtractive and additive implant surface modifying procedures over machined implant surfaces when the data were pooled together. More advanced research work on healthy animal models needs to be investigated to review the impact of surface modifications on dental implant osseointegration.
Comparative evaluation of hard and soft tissue parameters by using short implants and standard long implants with sinus lift for prosthetic rehabilitation of posterior maxilla
Authors: Durrani Farhan , Karthickraj S. M. , Imran Fouzia , Ahlawat Shweta , Kumari Ekta , Vani S. U. Gokila
Published: June 2024

Objective:

The objective is to compare and evaluate the hard and soft tissue parameters by using short and standard long implants with sinus lifting in the posterior maxilla.

Materials and Methods:

Eleven patients with complaints of missing upper back teeth were enrolled in the study for implant-supported rehabilitation and were categorized into two groups: Group long (GL): longer implant (>8 mm) placement, preceded by Sinus Augmentation. Group short (GS): short implant (≤8 mm) placement, without sinus augmentation. The primary outcome measured was cumulative survival rate (CSR) in the compromised partial edentulous posterior maxilla. Secondary outcomes measured were implant stability (IS), marginal bone level alterations (MBL), pocket probing depth (PPD), crown-to-implant ratio, and any complications.

Results:

The difference in CSR between the groups was not statistically significant (P = 0.317). High stability was achieved immediately after the placement of the implants, in both groups (GS: 64 ± 4.07, GL: 65.58 ± 9.75); this difference in the mean ISQ (IS quotients) values was not found to be statistically significant at implant placement (P = 0.7). The mean MBL reported in the study at the end of 12 months of prosthesis function was − 0.762 ± 0.48 mm and − 0.7 ± 0.34 mm for GS and GL, respectively. The mean PPD measurements in GS and GL groups were 1.917 ± 0.68 mm and 1.833 ± 0.38 mm, respectively, and it was not statistically significant (P = 0.8).

Conclusion:

Within the limitations of the present study, the obtained results indicate that short implants provided a similar clinical and radiographic performance compared to long implants placed in combination with a sinus augmentation procedure (lateral window) up to 12 months after prosthetic loading.
Convergence of inflammatory response: Salivary cytokine dynamics in coronavirus disease 2019 and periodontal disease
Authors: Gupta Shipra , Mohindra Ritin , Ramola Manisha , Kanta Poonam , Singla Mohita , Malhotra Meenakshi , Mehta Nishant , Goyal Ashima , Singh Mini P.
Published: June 2024

Background:

Periodontal disease is associated with immune dysregulation, and cytokines released can add on to the coronavirus disease 2019 (COVID-19)-associated cytokine storm, further worsening the related adverse outcomes. Specific studies investigating cytokine levels in COVID-19 patients with periodontal disease are lacking. Examining the correlation between these conditions could aid in categorizing risk categories, determining referrals, and strengthening oral hygiene protocols. The current study sought to evaluate cytokine levels in the saliva of COVID-19-positive patients with and without periodontal disease.

Materials and Methods:

Twenty-six COVID-19-positive patients were subjected to periodontal examination, saliva collection, and assessment of cytokine levels through cytokine bead-based multiplex assay, using fluorescence-encoded beads with flow cytometry (BD FACS LSRFortessa). Eleven cytokines were assessed (interleukin [IL] 2, 4, 6, 10, 17A, and interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2/monocyte chemoattractant protein-1), C-X-C motif chemokine ligand (CXCL) 8/IL 8, CXCL 9/monokine-induced gamma interferon [MIG]), and CXCL 10 (chemokine IFN-gamma inducible protein 10 kDa). The cytokine levels of the recruited subjects were also compared graphically with the salivary cytokine levels reported in the literature for health, COVID-19, and periodontal disease alone.

Results:

Out of 26 COVID-19-positive patients, 17 had periodontal disease. Levels of all cytokines were raised in patients with both diseases when compared to values reported in literature for health, periodontal disease alone, or COVID-19 alone. However, there was no statistical difference among the recruited subjects for IL-2, IL-4, IL-6, IL-10, IL-17A, IFN-gamma, TNF-α, CCL2, CXCL 8, and CXCL 10. MIG levels were found to be higher in periodontally healthy, COVID-19-positive subjects (P = 0.01).

Conclusions:

Periodontal disease might contribute to the COVID-19-induced cytokine storm, potentially amplifying its impact.
Brief overview of mpox: To worry or to ignore?
Authors: Purnamasidhi Cokorda Agung Wahyu , Junior Darren , Purnama Giovanca Verentzia , Suteja Richard Christian , Adiputra I Komang Hotra , Wulandari Putu Kintan , Diksha I Gusti Ngurah Ariestha Satya
Published: June 2024

Mpox was first discovered in the Democratic Republic of Congo as a zoonotic infectious disease with various possible transmission routes. Currently, it is a reemerging disease being monitored by the World Health Organization (WHO) after a surge of reported cases in several non-endemic countries in May 2022 and August 2023. This study probes into the issue of whether mpox should or should not be concerned as a potential threat during and after the current COVID-19 pandemic. Literature reviews were conducted using PubMed, DOAJ, and Cochrane to understand and synthesize more information on the virulence and lethality of mpox. The keywords used included “monkeypox”, “outbreak”, “reemerging infectious disease”, “southeast asia”, “smallpox”, “sars cov”, and “transmission”, which were all associated with the Boolean operators “AND” and “OR”. A total of 30 articles acquired from various journals and international official websites were included in this study. The sudden outbreaks across the Asia-Pacific region may be attributed to countries lifting their travel restrictions. Studies have shown that mpox has similar transmission routes to COVID-19 and manifests similar symptoms to smallpox. However, mpox needs prolonged contact for its transmission and has a lower case fatality rate (CFR). Several studies highlighted that current outbreaks have different epidemiological and clinical characteristics from classic cases. Mpox is not as highly transmissible as COVID-19 and not as severe as smallpox, but it still poses a potential threat to human health and needs further observation and immediate containment to prevent further transmission worldwide. The preparation of smallpox vaccination in case of emergency and further clinical trials of smallpox drugs are recommended.
Artificial intelligence in pediatric airway – A scoping review
Authors: Nemani Sugandhi , Goyal Shilpa , Sharma Ankur , Kothari Nikhil
Published: June 2024

Artificial intelligence is an ever-growing modality revolutionizing the field of medical science. It utilizes various computational models and algorithms and helps out in different sectors of healthcare. Here, in this scoping review, we are trying to evaluate the use of Artificial intelligence (AI) in the field of pediatric anesthesia, specifically in the more challenging domain, the pediatric airway. Different components within the domain of AI include machine learning, neural networks, deep learning, robotics, and computer vision. Electronic databases like Google Scholar, Cochrane databases, and Pubmed were searched. Different studies had heterogeneity of age groups, so all studies with children under 18 years of age were included and assessed. The use of AI was reviewed in the preoperative, intraoperative, and postoperative domains of pediatric anesthesia. The applicability of AI needs to be supplemented by clinical judgment for the final anticipation in various fields of medicine.
Should general anesthesiologists be certified to perform anesthesia for patients with morbid obesity undergoing bariatric surgery: A national web-based cross-sectional survey
Authors: Ahmed Abdulaziz E. , Alaqaili Abdulaziz F. , Elbashary Ahmed S. , Bin Muammar Abdullah F. , AlQarni Adel , Yamani Nada T. , Eldawlatly Abdelazeem A.
Published: June 2024

Background:

Bariatric surgery in Saudi Arabia has become one of the most performed surgical procedures for weight loss surgery (WLS). The aim of this survey is to highlight the importance of education and training in bariatric anesthesia (BA).

Methods:

An Internet-based cross-sectional survey was conducted to examine the percentages of general anesthesiologists among respondents who supported the need for formal structured training in BA as the primary outcome. A 41 items questionnaire on different aspects of BA included in this survey. All anesthesiologists in KSA participated in this survey.

Results:

42% responded giving anesthesia for bariatric surgery/year between 25 and 50% of cases/year. 22% responded performing 25–50 cases/month, 21% from 10–25 cases, and 14% from 50–100 cases. Compared with how many elective bariatric surgical procedures performed in your center/month revealed significant differences (P < 0.05), 39% responded with no dedicated team in their center, 14% for <10 cases a month, 9% between 25 and 50 cases a month. Compared to the number of cases performed by non-bariatric anesthetists revealed non-significant differences (P > 0.05), upon asking on how many trained/skilled anesthesiologists in bariatric anesthesia in your center, 24% reported none, 4% only one, 21% 2–5 anesthesiologists, 12% 5–10 anesthesiologists, and 19% of the respondents reported more than 10 anesthesiologists specialized in BA.

Conclusion:

We believe in education and training in bariatric anesthesia. Residents’ rotation in BA should be included in their curriculum. A dedicated fellowship program to be developed at a national level as well as courses and workshops.
Evaluation of effects of intravenous infusion of dexmedetomidine or lignocaine on stress response and postoperative pain in patients undergoing craniotomy for intracranial tumors: A randomized controlled exploratory study
Authors: Shekhar Shivam , Goyal Nishant , Mirza Anissa Atif , Agrawal Sanjay
Published: June 2024

Background:

Goals of anesthesia in neurosurgery include stable cerebral hemodynamics and provide relaxed brain to surgeon. Dexmedetomidine and lignocaine as an adjuvant can fulfill these criteria but literature comparing the two are sparse. We compared the effects of intravenous infusion of dexmedetomidine or lignocaine on stress response, postoperative pain, and recovery in patients undergoing craniotomy for intracranial tumors.

Methods:

Approval was obtained from IEC, and the study was prospectively registered (CTRI/2022/11/047434). Written and informed consent was obtained from 105 patients fulfilling inclusion criteria, and they were divided into three groups. Group D received intravenous infusion of dexmedetomidine 1 mcg/kg over 15 minutes followed by infusion at rate of 0.5 mcg/kg/h, Group L received intravenous infusion of lignocaine 2 mg/kg over 15 minutes followed by infusion at rate of 1.5 mg/kg/h, and Group N received intravenous infusion of normal saline at the rate of 4–8 ml/h till skin suturing. SPSS v23 (IBM Corp.) was used for data analysis.

Results:

There was a significant difference between groups in terms of intraoperative hemodynamic variations, brain relaxation score, extubation criteria, postoperative pain, stress indicator response, and quality of recovery.

Conclusions:

Dexmedetomidine as an adjuvant to anesthetic drugs has a better profile than lignocaine in suppressing stress response and preventing hemodynamic variations at intubation, skull pin application, and surgical incision. Dexmedetomidine increases the duration of effective analgesia more than lignocaine, in postoperative period in patients undergoing craniotomy.
Precision in practice: An audit study on low-flow anesthesia techniques with desflurane and sevoflurane for cost-effective and sustainable care
Authors: Chowdappa Gopinath Kenkare , Iolov Svetoslav Ivanov , Abuamra Khaled Saleh , Kulkarni Prasad Padmakar , Shariff Jameelulla Aleemulla , Abdelaziz Hatem Mohammed Khairy , Kumar Justin Arun
Published: June 2024

Introduction:

In the backdrop of escalating healthcare costs and an increasing focus on resource optimization, this audit study delves into the realm of anesthesia management, specifically exploring the application of low-flow anesthesia (LFA). The primary objective was to assess adherence to hospital standards and evaluate the economic implications of LFA (<1 L/min).

Materials and Methods:

This retrospective audit focused on 700 adult patients undergoing elective surgeries with general anesthesia. Data sources included anesthesia records, electronic recording systems, and audits by a dedicated team. Fresh gas flow rates (FGFRs), minimum alveolar concentration (MAC), and volatile anesthetic consumption were analyzed. Cost comparisons between low-flow and high-flow anesthesia were conducted, employing specific cost per milliliter metrics.

Results:

The average FGFR during the maintenance phase was found to be 0.45 ± 0.88 L/min. Adherence to hospital standards was notably high, with 94.29% of patients being maintained on low-flow gas rates. The differences in anesthetic consumption between low-flow and high-flow FGFR were statistically significant for both desflurane (12.17 ± 10.84 ml/MAC hour versus 43.12 ± 27.25 ml/MAC hour) and sevoflurane (3.48 ± 7.22 ml/MAC hour versus 5.20 ± 5.20 ml/MAC hour, P < 0.001). The calculated savings per patient with low-flow desflurane and sevoflurane anesthesia compared to high flow were found to be 109.25 AED and 6.74 AED, respectively.

Conclusion:

This audit advocates for the widespread adoption of LFA as a standard practice. Beyond aligning with hospital standards, the study highlights the multi-faceted benefits of LFA, encompassing economic savings, environmental safety, and enhanced patient care.
An in vitro technique to measure resistance to compression and kinking of endotracheal tubes
Authors: Young Emily , Nocera Tonya M. , Reilly Matthew , Tobias Joseph D. , D’Mello Ajay
Published: June 2024

Background:

During intraoperative care, ventilatory parameters including peak inflating pressure (PIP) and exhaled tidal volumes are continuously monitored to assess changes in respiratory resistance and compliance. Changes in these parameters, such as an increase in PIP or a decrease in the exhaled tidal volume, may indicate various pathologic processes that may require immediate attention to prevent inadequate ventilation resulting in hypoxemia or hypercarbia. A kinked endotracheal tube (ETT) may mimic other pathologic processes including bronchospasm, mainstem intubation, or ventilator malfunction. As newer ETTs are developed, a key factor in their design should be resistance to kinking or occlusion due to patient positioning.

Methods:

The current project developed and describes the process for using a repeatable in vitro mechanical test to determine resistance to kinking by an ETT.

Results:

The mechanical testing procedure can be used to determine the compression force and distance required to kink an ETT under different conditions including temperature. The force required to induce devastating kink failure was lower during heated testing conditions. The addition of airflow through the ETTs during compression testing confirms the occurrence of airway obstruction at approximately the same time a mechanical kink is observed on the force-versus-distance curves.

Conclusions:

These procedures may be used to characterize and evaluate ETT designs under in vitro conditions mimicking those in the clinical practice.
Endotracheal tube cuff position in relationship to the walls of the trachea: A retrospective computed tomography-based analysis
Authors: Wani Tariq M. , Siddique Ayesha Y. , Khan Wajahat N. , Rehman Saif , Tram Nguyen K. , Tobias Joseph D.
Published: June 2024

Background:

The use of cuffed endotracheal tubes (ETTs) has become the standard of care in pediatric practice. The rationale for the use of a cuffed ETT is to minimize pressure around the cricoid while providing an effective airway seal. However, safe care requires that the cuff lie distal to the cricoid ring following endotracheal intubation. The current study demonstrates the capability of computed tomography (CT) imaging in identifying the position of the cuff of the ETT in intubated patients.

Methods:

The study included patients ranging in age from 1 month to 10 years who underwent neck and chest CT imaging that required general anesthesia and endotracheal intubation. The location of the ETT and of the cuff within the airway was determined from axial CT images at three levels (proximal, middle, and distal). Anatomical orientations were tabulated, and percent chances of each orientation were determined for the ETT and the cuff.

Results:

The study cohort included 42 patients ranging in age from 1 to 114 months. An ETT with a polyvinylchloride cuff was used in 24 patients, and an ETT with a polyurethane cuff was used in 18 patients. The ETT was located near the posterior wall of the trachea in approximately 24–38% of patients, being most likely to be centrally located at the proximal end and at its mid-portion. The middle part of the cuff was most likely to be positioned in the mid-portion of the trachea but tended to skew anteriorly at both the proximal and distal ends.

Conclusion:

This is the first study using CT imaging to identify the uniformity of cuff inflation within the trachea in children. With commonly used cuffed ETTs, cuff inflation and the final position of ETT cuff within the tracheal lumen were not uniform. Future investigations are needed to determine the reasons for this asymmetry and its clinical implications.
Anesthetic management of a case of a lip mass with paraseptal emphysema and multiple bilateral giant bullae for surgical resection under mental nerve block
Authors: Haloi Prajnananda , Biswas Rahul , Bora Ananta K.
Published: June 2024

Anesthesia in patients with emphysematous giant bulla undergoing non-thoracic surgery is challenging and can cause serious complications. We report a successful case of lip mass resection in a 65-year-old male with paraseptal emphysema and giant bullae under regional anesthesia using a mental nerve block. The patient presented with a slow-growing ulcerative mass on his lower lip and had a history of non-compliant COPD management. An excisional biopsy was planned. Preoperative workup revealed extensive lung pathology with giant bullae. General anesthesia with positive pressure ventilation in patients with emphysematous giant bullae can cause compression of lung parenchyma, vena cava kinking, circulatory collapse, and even death. To circumvent such risks, regional anesthesia was preferred and surgery was successfully done under ultrasound-guided bilateral mental nerve block. The procedure was uneventful, with stable hemodynamics throughout.
Anesthetic management of a patient with congenital cyanotic heart anomaly for emergency surgery: A case report
Authors: Pahuja Heena , Nikhade Ravikiran , Bhure Anjali , Pingley Aishwarya
Published: June 2024

Among congenital cyanotic heart diseases (CHDs), situs inversus totalis with transposition of great vessels with a large ventricular septal defect (VSD) has a very low incidence of around 1 in 10,000. Hereby, we present a 16-year-old man with the aforementioned cardiac anomaly with cardiac arrhythmias, septic shock, and a history of road traffic accident-causing osteomyelitis of the left thigh requiring incision and drainage. The patient was admitted to the intensive care unit with a high-grade fever, narrow pulse pressure, and atrial fibrillation. The patient was operated on under general anesthesia with endotracheal intubation after optimization. Invasive monitoring, antiarrhythmics, and vasopressors were required intraoperatively, and surgery progressed uneventfully. Furthermore, the patient had undergone a series of debridements after 8 days, which were performed under regional anesthesia uneventfully. This case report represents a plan of action for perioperative anesthetic management and anticipates the difficulties for CHD patients in the course of surgery and subsequential prudence.
Simultaneous use of GlideScope® in emergency department: A case report
Authors: Pulitanò R. , Giudice Marco , Di Sabatino Enrico , La Verde Francesca
Published: June 2024

The GlideScope® is a videolaryngoscope manufactured by Verathon Medical (Bothell, WA, USA), now widely used to manage planned or unexpected difficult orotracheal intubation situations. According to the current literature, GlideScope® has been used for surgical procedures involving the tongue base, such as biopsies and radiofrequency treatment of obstructive sleep apnea. We describe a case of dual use of GlideScope for pointed foreign body removal in an emergency department.
Anesthetic considerations of EXIT procedure: A case report
Authors: Alotaibi Narjes S. , Aqil Mansour , Sabr Yasser , Baaj Jumana , Alsafar Reem
Published: June 2024

The ex-utero intrapartum treatment (EXIT) is a rare surgical procedure performed in cases of expected postpartum fetal airway obstruction. This procedure technique lies in a safe establishment of a patent airway during labor in anticipation of a critical respiratory event, without the interruption of maternal-fetal circulation. Anesthetic management in the EXIT procedure is substantially different from that of the standard cesarean delivery and its main goals include uterine relaxation, fetal anesthesia, and placental blood flow preservation. We report the first case of an EXIT procedure performed on a fetus with a prenatal diagnosis of multiple oral masses at King Khalid University Hospital, Riyadh, Saudi Arabia.
Local analog of the Deligne-Riemann-Roch isomorphism for line bundles in relative dimension $1$
Authors: Osipov Denis Vasilievich
Published: June 2024

We prove a local analog of the Deligne-Riemann-Roch isomorphism in the case of line bundles and relative dimension $1$. This local analog consists in computation of the class of $12$th power of the determinant central extension of a group ind-scheme $\mathcal G$ by the multiplicative group scheme over $\mathbb Q$ via the product of $2$-cocyles in the second cohomology group. These $2$-cocycles are the compositions of the Contou-Carrère symbol with the $\cup$-product of $1$-cocycles. The group ind-scheme $\mathcal{G}$ represents the functor which assigns to every commutative ring $A$ the group that is the semidirect product of the group $A((t))^*$ of invertible elements of $A((t))$ and the group of continuous $A$-automorphisms of $A$-algebra $A((t))$. The determinant central extension naturally acts on the determinant line bundle on the moduli stack of geometric data (proper quintets). A proper quintet is a collection of a proper family of curves over $\operatorname{Spec} A$, a line bundle on this family, a section of this family, a relative formal parameter at the section, a formal trivialization of the bundle at the section that satisfy further conditions.
Bibliography: 31 titles.
Inverse problems for evolutionary quasi-variational hemivariational inequalities with application to mixed boundary value problems
Authors: Peng Zijia , Yang Guangkun , Liu Zhenhai , Migórski Stanislaw
Published: June 2024

The aim of this paper is to examine an inverse problem of parameter identification in an evolutionary quasi-variational hemivariational inequality in infinite dimensional reflexive Banach spaces. First, the solvability and compactness of the solution set to the inequality are established by employing a fixed point argument and tools of non-linear analysis. Then, general existence and compactness results for the inverse problem have been proved. Finally, we illustrate the applicability of the results in the study of an identification problem for an initial-boundary value problem of parabolic type with mixed multivalued and non-monotone boundary conditions and a state constraint.
Bibliography: 48 titles.
О теоретико-потенциальных задачах, связанных с асимптотикой многочленов Эрмита-Паде
Authors: Ikonomov Nikolay Rumenov , Suetin Sergey Pavlovich
Published: June 2024

Рассматриваются смешанные теоретико-потенциальные задачи равновесия. Задачи связаны с изучением асимптотических свойств рациональных аппроксимаций, основанных на многочленах Эрмита-Паде 2-го типа для систем Никишина.
Библиография: 26 названий.
О приближениях одного сингулярного интеграла на отрезке рациональными интегральными операторами Фурье-Чебышeва
Authors: Potseiko Pavel Gennadjevich , Rovba Evgeny Alekseevich
Published: June 2024

Исследуются аппроксимации на отрезке $[-1,1]$ сингулярных интегралов вида
$$
\widehat{f}(x)=\int_{-1}^{1}\frac{f(t)}{t-x}\sqrt{1-t^2} dt, \qquad x \in [-1,1],
$$
двумя рациональными интегральными операторами, в некотором смысле связанными между собой. Первый из них - интегральный оператор Фурье-Чебышeва, ассоциированный с системой рациональных функций Чебышeва-Маркова. Второй оператор является его образом при преобразовании изучаемым сингулярным интегралом.
Изучаются аппроксимационные свойства соответствующих полиномиальных аналогов обоих операторов в случае, когда плотность сингулярного интеграла удовлетворяет на отрезке $[-1,1]$ условию Липшица порядка $\alpha \in (0,1]$.
Исследуются рациональные аппроксимации на отрезке $[-1,1]$ сингулярного интеграла с плотностью, имеющей степенную особенность. Рассматривается случай, когда аппроксимирующие рациональные функции имеют произвольное фиксированное количество геометрически различных полюсов, и случай, когда параметры аппроксимирующих рациональных функций представляют собой некоторые модификации "ньюменовских" параметров.
Библиография: 34 названия.
Characterization of Leuconostoc lactis Bacteremia during a 2-year Study at a Tertiary Care Center in North India—An Observational Analysis
Authors: Tripathy Sarvodaya , Jamwal Ashima , Varghese Gerlin , Sarawat Deepika , Patel Sangram Singh , Tejan Nidhi , Sahu Chinmoy
Published: June 2024

Leuconostoc species are regarded as important causes for many infections in immunocompromised patients. In this study, we assessed the characteristics of Leuconostoc spp. causing bacteremia in patients at our center. This observational analysis was conducted in the microbiology laboratory of a tertiary care center in northern India from July 2021 to July 2023. Patients in whom blood culture bottles were positive for Leuconostoc lactis were included in the study. Culture isolates were identified by MALDI-ToF MS as L. lactis and tested for antibiotic sensitivity results by Kirby–Bauer disk diffusion method. Demographic and clinical details were collected and analyzed. During the study period, 6,742 blood culture bottles flagged positive. Among these, L. lactis was isolated from 14 (0.21%) patients. The median patient age was 34 years. The male-to-female ratio was 2.5:1. All the patients with L. lactis bacteremia had an underlying condition leading to immunosuppression (e.g., carcinoma and chronic kidney disease). All the patients with L. lactis bacteremia had an intravascular device present at the time of bacteremia. All isolates in the study were sensitive to doxycycline, high level gentamicin, minocycline, ampicillin-sulbactam, and linezolid. Mortality was attributed to bacteremia by L. lactis in five patients. Appropriate and timely identification of the Leuconostoc species is important for the clinician to tailor regimens for the patients.
Utilising pharmacy students to extend academic detailing services focused on naloxone and opioid overdose education
Authors: Linder Lauren , Pruitt Megan , Ball Sarah , Wisniewski Christopher , Weed Elizabeth
Published: June 2024

Background: Academic detailing (AD) visits with community pharmacists can effectively increase naloxone access. Pharmacy students, introduced to AD principles, engage pharmacists in guided conversations on naloxone, expanding access and existing AD services. This report outlines an educational initiative to expand an existing AD service to community-based pharmacies.
Methods: Seventy-one first-year pharmacy students attended two virtual AD principles and naloxone training sessions. Students were subsequently required to have a guided conversation with their preceptor on offering naloxone and overdose education and complete an anonymous post-visit survey on their experience, understanding of current practice, and pharmacist-intended behaviour change.
Results: Fifty-two self-reported student surveys were assessed. Responses indicated that the following percentages of students believed their preceptor would: (1) start providing opioid overdose education to patients (42%; n=22/52), (2) demonstrate proper use of naloxone to patients at the time of naloxone dispensation (23%; n=12/52), (3) dispense naloxone without a prescription (17%; n=9/52), and (4) keep naloxone in stock (10%; n=5/52). The majority (81%; n=42/52) of students found this experience beneficial, and 69% (n=36/52) indicated they would like to participate in educational outreach again.
Conclusion: An innovative pharmacy student initiative allowed an AD service to extend face-to-face outreach to community pharmacists and promote the expansion of naloxone and opioid overdose education.
Cardiovascular risk assessment of the general population at a community pharmacy setting
Authors: Eze Uchenna I.H , Eze Michael S.C , Iheanacho Chinonyerem , Igbinaduwa Patrick
Published: June 2024

Background: The increasing burden of cardiovascular diseases (CVDs) suggests the need for early detection of risks. This study assessed the outcomes of community pharmacy-based screening for CVD risks and the association of sociodemographic characteristics with health parameters.
Methods: A cross-sectional study was conducted among healthy consumers of community pharmacy services aged 18 and above. Interventions included the measurement of blood pressure, waist-to-hip ratio, height/weight, visceral fat, and CVD risks. Study endpoints were outcomes of community pharmacy-based screenings and the association of sociodemographics with health parameters.
Results: A high prevalence of elevated blood pressure 212 (53.1%), high visceral fat 167 (41.8%), high waist-to-hip ratio 176 (44.1%), and high body mass index (BMI) 251 (62.9%) were observed among the 400 study participants. Of the 152 (38.0%) with CVD risks, 84 (55.3%) had a medium risk. Age was statistically significant for CVD risks, blood pressure, heart rate, and BMI. Occupation was statistically significant for CVD risks and heart rate. Marital status was significantly associated with CVD risk.
Conclusion: Several outcomes were observed, including a high prevalence of hypertension, high BMI, waist-to-hip ratio, and overall medium CVD risks. These findings suggest the need for increased and targeted educational interventions.
Safety outcomes of remdesivir for treatment of COVID-19 hospitalised patients in Indonesia
Authors: Hasmono Didik , Samirah Samirah , Hartono Ruddy , Subkhan Mohammad , Yoshida Maria Angelia , Leliga Fenny Kesuma
Published: June 2024

Background: Remdesivir has been granted emergency use authorisation for hospitalised COVID-19 patients. However, the available evidence in Indonesia is limited to related liver and kidney injuries.
Objective: This study aims to assess the safety of remdesivir based on liver and kidney function and its association with comorbidity and disease severity.
Method: This retrospective study evaluated remdesivir's efficacy in hospitalised COVID-19 patients of varying severity by collecting baseline and follow-up data on aspartate aminotransferase (AST), alanine aminotransferase (ALT), Glomerular filtration rate (GFR) and Blood urea nitrogen (BUN).
Result: In this study, 189 patients with elevated transaminase enzyme levels were given hepatoprotection therapy. Patients who did not receive the treatment experienced a significant rise in ALT levels (p < 0.001), while BUN levels increased significantly (p = 0.001) but within the normal range. There was no worsening of GFR value (p < 0.001), and no significant association was found between AST and ALT levels with comorbidity and disease severity (p < 0.001; OR 50.202).
Conclusion: Remdesivir demonstrated good tolerability despite increased ALT and BUN without correlating to comorbidity or disease severity in COVID-19.
Testing the aphrodisiac effects of Sterculia quadrifida (faloak) bark powder on male white rats (Rattus norvegicus)
Authors: Sambara Jefrin , Yuliani Ni Nyoman , Upa Muhamad Satria Pua , Rahmat Emanuel Gerald Alan
Published: June 2024

Background: Sterculia quadrifida R.Br has been widely known and, empirically, has been widely used as an herbal ingredient to overcome sexual disorders in men.
Objective:  This study aims to assess the quality, stability, and aphrodisiac properties of faloak bark solution preparations (from plants R.Br Sterculia quadrifida) found on Timor Island, specifically on male white rats of the Wistar strain.
Method: This research is a type of experimental research. The activity test used two variations of the formula (50%, 100%) extract, positive and negative control tests. Data were analysed with one-way ANOVA (p < 0.05).
Result: The test results of extract quality and stability, including moisture content, resting angle, flow speed, dissolving time, organoleptic test, pH, specific gravity, clarity, and homogeneity, met the requirements. The analysis results found significant differences in each test group (p < 0.05), and there were substantial differences between the negative control group and the positive control group, formula one and formula two.
Conclusion: The preparation of the solution of Sterculia quadrifida R. met the established quality and stability. The results of the aphrodisiac test of the effect of Sterculia quadrifida R.Br on the parameters of introduction and climbing activity showed significant activity compared to the negative control group.
Calidad de los sistemas de contabilidad de costos en las empresas manufactureras: un estudio de revisión sistemática
Authors: Bautista Daza Fabiana Darnelly , Ramos Dorado Robinson Durley , Ulloa Méndez Carmen Isabel , Hurtado García Ketty del Rocío
Published: June 2024

El problema evidencia la falta de consenso sobre estándares claros y la influencia de factores contextuales. La calidad deficiente en estos sistemas puede resultar en informes inexactos, afectando la gestión financiera y estratégica. Por tal razón, el objetivo de la investigación se basó en determinar si la calidad de los sistemas de contabilidad de costos tiene un impacto en la calidad de la información utilizada para tomar decisiones. Para la metodología se utilizó un enfoque cualitativo se empleará en la investigación debido a su capacidad para explorar la complejidad y profundidad de este fenómeno. En el contexto de la contabilidad de costos, las experiencias, percepciones y prácticas de los actores clave, Esta investigación presenta la revisión sistemática sobre el estado actual de la investigación asociada a la calidad de los sistemas de contabilidad de en empresas manufactureras. La muestra de estudio constó de 40 artículos. Los resultados evidenciaron que algunas empresas manufactureras están adoptando gradualmente la contabilidad de costos. Por tal razón, la comunidad directiva tomó conciencia de la creciente competencia mundial entre empresas privada. Se concluye que, capacitar a los empleados para operar la calidad de los sistemas de contabilidad de costos moderno ayudó a aumentar la confianza y reducir los errores.
Penerapan Model Problem Based Learning untuk Menumbuhkan Penguasaan Konsep, Keterampilan Berpikir Kritis, dan Sikap Hormat Peserta Didik Kelas III di Sekolah XYZ
Authors: Susanto Winny
Published: June 2024

Education is defined as a conscious and planned activity through a learning process that can help develop individual potential. Self-potential includes spiritual strength, intelligence, noble character, self-control, personality, and skills needed for individuals and society. XYX School has a school vision that is respect and critical thinking, but this has not been reflected in students. The purpose of this study was to analyze the application of the Problem Based Learning model in improving mastery of mathematics concepts, critical thinking skills and respectful attitudes of 3rd grade students at XYZ school. The research method used is classroom action research. The research instruments used were written tests to measure mastery of mathematical concepts and observation rubrics to measure critical thinking skills. The results showed that there was an increase in the mastery of mathematical concepts of students by 30%. An increase in critical thinking skills was also obtained with an N-gain value of 0.50 during the study. The increase in respectful attitude can be seen from the N-gain value obtained of 0.41 during the study. It can be concluded that the application of the Problem Based Learning model can improve concept mastery, critical thinking skills and respectful attitude in mathematics lessons for grade 3 students of XYZ school.
TEK PARTİ DÖNEMİNİN TEMEL DİNAMİKLERİ ÜZERİNE TARTIŞMALAR
Authors: Daglar Macar Oya , Şen Erdoğan
Published: June 2024

Türk siyasi hayatında 1923-1945 arası dönem tek parti dönemi olarak tarihe geçmiştir. Bu aynı zamanda yeni Türkiye Cumhuriyeti’nin kuruluş dönemi olarak siyasi, ekonomik ve toplumsal pek çok dönüşümün yaşandığı bir tarihtir. Tek parti döneminin siyasi dinamiklerini iyi anlamak Türkiye’nin siyasi yapılanmasını, devletin temel kurum ve kuruluşlarını, hukuk sistemini ve sosyal yapıdaki değişimi anlamak için zorunludur. Tek Parti dönemi bugüne kadar pek çok açıdan incelenmiş, tartışılmış ve eleştirilmiştir. Bu makale söz konusu döneme damgasını vurmuş olan Cumhuriyet Halk Partisi ‘nin kuruluş dinamikleri ve tek parti dönemi üzerine yapılan tartışmalar üzerine odaklanmaktadır. Milli Mücadele’de Anadolu ve Rumeli Müdafaa-i hukuk Cemiyeti’nden Cumhuriyetle birlikte Cumhuriyet Halk Fırkasına dönüştürülen bu partinin tarihi aynı zamanda erken cumhuriyetin tarihidir. Makalede nitel araştırma yöntemi kullanılarak, döneme ilişkin gelişmeler ve tartışmalar yorumlayıcı bir yaklaşımla ele alınmaya çalışılmıştır.
Safeguarding Heritage: Preserving Traditional Knowledge in Global Patent Law
Authors:   Master of Legal Studies Postgraduate Program, Faculty of Law, Universitas Indonesia, Depok, West Java 16424, Indonesia., Furqon Muhamad Sigit Al
Published: June 2024

The present study investigates the defensive safeguarding of traditional knowledge within the framework of international patent law. The chosen research methodology is evaluative, employing secondary data sources. The primary emphasis of this study is on primary and secondary legal materials. The process of data analysis involves the utilisation of qualitative juridical analysis techniques. The findings suggest that traditional knowledge has distinct attributes intricately linked to traditional communal elements and spans diverse areas of human existence. The safeguarding of traditional knowledge is paramount to uphold principles of fairness, environmental preservation, cultural heritage, prevention of misappropriation, and the advancement of sustainable utilisation. In international patent law, there is a notable incongruity between traditional knowledge and patent systems that prioritise human ingenuity and originality. The efficacy of patent systems in protecting traditional information is limited by the inherent characteristics of traditional knowledge, which is often collective and transmitted orally. The safeguarding of traditional knowledge necessitates a harmonious integration of both legal and practical dimensions. These endeavours encompass the acknowledgement of pre-existing knowledge and inventions, the creation of organisations to oversee safeguarding, and the implementation of pragmatic strategies to guarantee availability and equitable utilisation. The ability to patent novel discoveries derived from traditional knowledge is possible; nevertheless, conflicts often occur due to disparities between patent regimes and the inherent characteristics of traditional knowledge. In the present situation, it is imperative to adopt a comprehensive and equitable strategy to safeguard traditional knowledge’s long-term viability within the intellectual property framework.