bluuebunny/crossref_metadata_2025 huggingface dataset:
MEDICAL AND ORGANIZATIONAL ASPECTS OF OPTIMIZING THE ADMITTING DEPARTMENT ACTIVITIES IN AN EMERGENCY HOSPITAL
Authors:   Ministry of Health of Voronezh Region, BANIN IGOR N. , KONOVALOV OLEG E. ,   Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia, SHULAEV ALEXEY V. ,   Kazan State Medical University, BREUSOV ALEXEY V. ,   Medical Institute, Patrice Lumumba Peoples’ Friendship University of Russia
Published: December 2024

Introduction. Public medical care accessibility and quality are strategic objectives of domestic healthcare.
Successfully solving these problems is greatly facilitated by the efficient operation of 24-hour hospitals, which largely
depends on the quality of the admitting department that significantly impacts the efficiency of the entire hospital. Aim
of the study is to optimize the admitting department activities of a multidisciplinary emergency hospital, based on
reasonably organized admission of patients, differentiated sorting, and subsequent routing of patients depending on
their condition severity. Materials and Methods. The study was carried out based on Voronezh City Clinical Hospital
of Emergency Medical Care No. 1, which is a 24-hour multidisciplinary hospital with a capacity of 800 beds. The study
was aimed at the main activities of the admitting department of the said hospital and ways to optimize them. To achieve
our goals, we used analytical, statistical, and system analysis research methods. Statistical data processing was carried
out using the StatSoft STATISTICA software program. The assessment of the study results is presented in the M±SD
format (M – mean, SD – standard deviation). Results and Discussion. An analysis of the structure of the medical
advice-seekers in the hospital showed that 42 % of patients were delivered to the hospital by an ambulance team, 32.7
% were admitted by the medical institution, and 25.3 % appeared by “self-referral”, which, taking into account their
varying condition severities and comorbidity pathologies, required additional time spent on re-issuing medical documents,
re-entering patients’ personal data into the medical information system, and providing different scopes of medical care.
To increase the efficiency of the admitting department and the entire hospital, the position of a hospital administrator on
duty was introduced; the medical triage system (triage) was developed and implemented, which, at contacting them,
allows dividing patients into 3 streams differing in the demand for homogeneous treatment and prevention measures, and
queuing for such activities, which made it possible to develop universal standard operating procedures and significantly
improve the key indicators of hospital activities. Conclusions. As a result, innovative approaches have been proposed
to optimize the admitting department activities of an emergency hospital, related to the elements of lean healthcare,
which allows differentiated medical triage followed by patients’ routing depending on their condition severity
STUDYING THE MITOCHONDRIAL TOXICITY OF PARACETAMOL AND ITS METABOLITE NAPQI
Authors:   National Medical Research Center named after V.A. Almazov, Saint Petersburg, BATRAKOVA KSENIYA V. ,   National Medical Research Center named after V.A. Almazov, Saint Petersburg, GOLOVANOVA NATALYA E. ,   St. Petersburg State University, TUVALEVA LIA S. ,   Bashkir State Medical University, KURAMSHINA OLGA A. ,   Bashkir State Medical University, NIGMATULLIN RUSTEM KH. ,   Medical Unit MIA of Russia in the Republic of Bashkortostan, GRISHINA ANASTASIYА R. ,   National Medical Research Center named after V.A. Almazov, Saint Petersburg, USACHEVA KSENIYA V. ,   National Medical Research Center named after V.A. Almazov, Saint Petersburg
Published: December 2024

Introduction. Antipyretic effect of paracetamol has been known since the late 19th century. But the safety profile
of this drug started to be analyzed much later, when some toxic effects were identified in using a drug that contained
paracetamol, the most widely known of which was drug-induced liver damage. Aim. To study the effects of paracetamol
and its toxic metabolite N-acetyl-p-benzoquinone-imine on the viability and mitochondrial membrane potential of astroglial
cells in the cerebral cortex of newborn rats. Materials and Methods. Isolated astrocytes from the brains of newborn
rats were exposed to 1 mM of paracetamol or 0.15 mM of its toxic metabolite NAPQI for 24 hours, then cell viability
(colorimetric test for assessing the metabolic activity of cells, i.e. MTT method) and mitochondrial membrane potential
(using TMPE fluorochrome) were identified. Results and Discussion. The paracetamol metabolite NAPQI decreased
cell viability from 0.57 ± 0.02 down to 0.4507 ± 0.03 a.u. and mitochondrial membrane potential from 0.19±0.01 down
to 0.16±0.003 a.u., the differences are significant compared to the control (p <0.05). Conclusions. The results obtained
indicate the toxic effect provided by the paracetamol metabolite NAPQI on astroglial cells in the brains of newborn rats.
Keywords: paracetamol, NAPQI, mitochondrial toxicity, astroglial cells.
DEPARTMENT OF PUBLIC HEALTH AND HEALTHCARE OF THE PRIVOLZHSKY RESEARCH MEDICAL UNIVERSITY: A HISTORICAL FORGE OF RESEARCH PERSONNEL - HEALTHCARE PROFESSIONALS (On the occasion of the 125th anniversary of the birth of SOPHIA I. SKUNDINA)
Authors:   Privolzhsky Research Medical University, GURVICH NADEZHDA I. , KOPTEVA LARISA N. ,   Privolzhsky Research Medical University, PEREVEZENTSEV EGOR A. ,   Privolzhsky Research Medical University, KAFIDOVA TATYANA I. ,   Privolzhsky Research Medical University, POSTNIKOVA ANNA D. ,   Privolzhsky Research Medical University, BARANOV ANDREY D. ,   Privolzhsky Research Medical University
Published: December 2024

Introduction. Department of Public Health and Healthcare of the Privolzhsky Research Medical University
has a rich history and traditions dating back to the 1930s. The main areas of scientific, educational and practical
activities of the department has always been the training of qualified researchers, competent administrators, and
healthcare professionals for medical institutions and healthcare authorities. The aim of our study was to analyze the
activities of the Department of Public Health and Healthcare of the Privolzhsky Research Medical University and show
its development in historical context. Materials and Methods. Historical data was analyzed and summarized based on
the regulatory and legal acts of the Privolzhsky Research Medical University, educational and scientific publications of
the department, as well as biographies and research and pedagogical performance of the employees of the department.
Results and Discussion. Department of Public Health and Healthcare was founded in 1931. Its founder and first
head was Doctor of Medical Sciences, Professor Sophia I. Skundina (Head of the Department of Social Hygiene and
Healthcare Organization in 1931-1951). Throughout the history of the Department of Public Health and Healthcare,
scientific research was influenced by the most pressing health problems. Professors, associate professors and assistant
professors of the department made a great contribution to the development of the research activities of the university
and took an active part in the healthcare restructuring in Nizhny Novgorod and the region. Currently, the department
is constantly improving its educational and methodological activities, introducing distance learning technologies and
developing new additional subjects and postgraduate education programs. Conclusions. The long development
of science at the department laid the foundation for the development of some modern scientific areas. Their further
development, systematization and generalization made it possible to organize a full-fledged, constantly growing and
expanding scientific school, the potential of which allows us to remain on the continuously updated wave of problems
of the state in general, and healthcare in particular.
ANALYSIS VIOLIN TECHNIQUE ON ZIGEUNERWEISEN FROM PABLO MARTIN MELITON DE SARASTE Y BAVAZCUES OP. 20
Authors: Iskandar Farih Ibnu Iskandar
Published: December 2024

Abstract: This research using a qualitative research methods with a musicological approach.  This research was conducted in February – June 2021, at the writer's place, located at Jl.  Al-Nur RT 01/ RW 06 No.70 Kel.  Pabuaran, Kec.  Cibinong, Kab.  Bogor, West Java.  The Data collection is done by using Literature review, Documentation Study, Observation and Interview.  Other than that, the data analysis techniques that the writer used for the research are Data Reduction, Codeing, Data Presentation, and Drawing Conclusions.  In testing the validity of the data, the writer using the Triangulation Technique.The result of this study is the writer find out that the work of Zigeunerweisen (Gypsi Airs) Pablo de`Sarasate Op.20 has 1 movement consisting of 4 parts, there are Moderato, Lento, Un Peu Plus Lento (in C minor scales), and Allegro molto Vivace (in C minor scales).  a minor).  The techniques contained in these work are including Legato, Sull, Spiccato, Flying Staccato, Multiple Stops, Ricochet, Pizzicato left and right hand, Portamento and Glissando, natural and artificial harmonics.
 
Keywords: Technique, Violin, Zigeunerweisen, Pablo de`Sarasate Op.20
MUSIC LEARNING USING A PROJECT BASED LEARNING METHOD FOR GRADE XI
Authors: Ridwan Setia Putra
Published: December 2024

The aim of this study is to create a music lesson plan using a project-based learning model. The research methodology used in this study is qualitative study with a descriptive approach. The data collection procedure used in this research is documentary research. The data analysis procedure used in this study are stages of data reduction, data presentation, and verification. The results of the study is the researcher made lesson plans for 7 (seven) meetings, each meeting has a duration of 90 minutes (2 hours of lessons x 45 minutes). In the compiled lesson plans, which the researcher has made, contain 3 (three) steps of learning activities, namely preliminary activities, main activities and closing activities.
STRENGTHENING 21st CENTURY EDUCATION THROUGH LEARNING MUSIC ENSAMBELS
Authors: Rehuela Abigail , Tarwiyah Adi Sam Tuti
Published: December 2024

The purpose of this research is to know, and describe the strengthening of 21st Century Education through ensemble music learning through ensemble music learning. The research method used in this research is literature study, with literature, with data collection techniques in the form of; literature study, interviews. The results of the research obtained that 21st century education and music ensemble learning have many elements in common, so that both have the same elements, so both are suitable and build each other. Education of the 21st century is not education that is made suddenly, the education has been designed at the time of the 2013 curriculum. Education was already designed when the 2013 curriculum was running. 21st century education is made with learning that depends on students (student centred), besides that, the role of the teacher remains important, to facilitate students. Skills applied in 21st century education, namely; critical thinking, creativity, collaboration, communication. With the competencies that competencies that have been designed and applied from the beginning, it can be ascertained that by mastering these things, learners can be more mastering these things, students can be more responsive to changes and developments in the changes and developments of the times, not only at school, but also in their environment, and even until the learners grow up.
PHYSICAL FORM OF ANGKLUNG AS THE EMBODIMENT OF ITS COSMOLOGY AND SOCIAL PURPOSE
Authors: Salley Anwary Sumadi Roly , Triharini Meirina
Published: December 2024

Angklung, a traditional musical instrument from West Java, Indonesia, has undergone significant development in various aspects. This study examines the evolution of angklung in terms of its physical form, musical application, and socio-cultural significance. The research employs a literature review method by collecting data from relevant sources. Findings revealed that socio-culturally, angklung has not only maintained its relevance but also gained increasing popularity and appreciation, both domestically and internationally. The study concludes that angklung, as a traditional artistic artifact, continuously evolves and adapts to the times without losing its cultural essence.
BRASS MARCHING BAND TRAINING AT DAAR EL-QOLAM ISLAMIC BOARDING SCHOOL
Authors: Azmi Najwa , Mas Aditya Andriyanto Raden , Ikasari Ichwan Clemy
Published: December 2024

The purpose of this study was to determine the training process for brass instruments in marching bands at the Daar El-Qolam Islamic Boarding School, Banten. The research method used is descriptive qualitative method. Data collection techniques used in this study were direct observation, interviews with sources and experts, as well as written sources. The data analysis technique used in this study is by means of data reduction, data presentation and drawing conclusions. The results of this study indicate that the training of brass instruments in marching bands at the Modern Islamic Boarding School Daar El-Qolam Banten has a routine training schedule of three times a week. There are 4 types of brass instruments used, namely trumpet, mellophone, baritone and tuba. The determination of the material provided is adjusted for new brass members and old brass members. The training methods used by the trainers are the lecture method, the demonstration method, the drill method and the imitation method. Marching band activities have very good benefits, including being able to increase the confidence of the members, that with this activity they are able to appear in front of many people, this confidence will be very beneficial for their future life in facing various challenges and obstacles in their life. A marching band member will also have loyalty, good leadership, achievement and also have good teamwork.
ENCLUSION OF TRADITIONAL ANDUNG ARTS AT THE SANGGAR SENI BUDAYA TUNAS KELAPA SAMOSIR
Authors: Panggabean Ente Lina , Evelin Limbong Helena , Hardiarini Caecilia
Published: December 2024

This research aims to describe the process of Enculturation of Traditional Art Andung in Sanggar Seni Budaya Tunas Kelapa Samosir. In the process of enculturation, of course, it has the support of the local government, namely by helping in terms of sanggar needs. Efforts to maintain Andung traditional arts, Sanggar Seni Budaya Tunas Kelapa Samosir also uses social media as a platform that is used to introduce traditional Andung arts such as Youtobe, Facebook and Instagram. The process of Enculturation of Traditional Art Andung occurs through non-formal channels that are through (sanggar) which is held regularly and the training process is carried out at Sanggar Seni Budaya Tunas Kelapa Samosir every Thursday at 14.00 to 17.00 with the arrangement of the Andung art learning process in Sanggar Seni Budaya Tunas Kelapa Samosir starting from the stage, namely: Introducing Andung art, then the students see, and imitate what has been taught by the coach, then the coaching process occurs.  This research uses qualitative descriptive using survey methods; observations, in-depth interviews (indepfh interviews), and documentation
A Robust Machine Learning Framework for Fraudulent Mobile App Detection
Authors: Hassan Zaki  , Saad Muhammad , Rasheed Muhammad Rehan
Published: December 2024

The rapid development of mobile applications has led to a significant rise in the number of fraudulent applications. The biggest risk now is financial loss and possible security compromise. Thus, the "Fraud App Detection" framework goal is to develop a reliable system that can recognize and categorize fraudulent apps utilizing cutting-edge machinelearning and artificial intelligence approaches. The process of identifying fraudulent patterns involves gathering data, preprocessing applications, extracting features, and training several machine learning models. The model’s performance will be assessed based on evaluation criteria like recall, accuracy, and F1-score. To improve detection efficiencyand accuracy, this uses cutting-edge techniques such as neural networks, decision trees, and ensemble approaches. These results can be used in enhancing mobile app security protocols, thus safeguarding consumers from the probable threats of fraudulent applications.
Stock Market Prediction using LSTM Model on the News and Social Media Data
Authors: Khan Wasiat , Ghazanfar Mustansar Ali , Javed Ali , Khan Faheem Ullah , Shah Yaser Ali , Ali Shaukat
Published: December 2024

Accurately predicting future trends in stock market is essential for investors because it increases the chances of a successful investment in the market. However, making precise predictions is challenging due to stock market volatility and influence of external factors from news and social media. Although various machine and deep learning techniques have been used to predict stock markets, none of them have been evaluated for short and medium-term forecasting. Therefore, we propose time series prediction method called Long Short-Term Memory (LSTM) to forecast stock markets over the short and medium terms, utilizing data sets with external variables. The proposed model is compared with baseline models including Multilayer Perceptron (MLP), Support Vector Machine (SVM), and K-Nearest Neighbor (KNN). The external features are collected from the news and social media after preprocessing and feature engineering of the textual data. The models are then applied on historical, social media, and financial news data from HPQ, IBM, ORCL, and MSFT stock markets. The experimental results demonstrate that LSTM performs best for medium-term predictions, with maximum accuracies of 81.5% and 87.5% on social media and news data, respectively, while MLP shows best performance for short-term predictions.
TVET-SCon: A Unified Catalyst Framework for Enhancing Youth Employability
Authors: Hassan Rana Hammad , Anees Tayyaba
Published: December 2024

Technical and Vocational Education and Training (TVET) plays a vital role in fostering a skilled workforce, crucial for sustainable development, poverty alleviation, and enhancing youth employability. However, the employability of TVET graduates remains a significant challenge, particularly in Pakistan, where issues such as low employability rates, skill shortages, and misalignment between industry needs and TVET outputs are prevalent. This qualitative study aims to address these challenges by introducing the TVET Skills Connect (TVET-SCon) framework—a unified catalyst designed to improve employability within the TVET ecosystem. Utilizing the Design Science Research methodology and Evolutionary Prototyping, the research involved comprehensive data collection through interviews, focus groups, and expert observations. Specifically, the study engaged 132 industry employers, 20 TVET teachers, and 326 trainees, alongside a detailed analysis of Pakistan’s TVET placement infrastructure and data systems. The research uncovers significant fragmentation within Pakistan's TVET placement system, revealing communication gaps, insufficient feedback channels, outdated job listings, and difficulties in aligning trainee skills with industry requirements. Data analysis further exposes a troubling mismatch where TVET programs supply 70\% more labor than the industry requires. The TVET-SCon framework addresses these issues by integrating stakeholders across the TVET ecosystem to enhance coordination and effectiveness. Its design not only tackles the specific problems identified but also offers a flexible model that can be adapted to similar contexts in other developing countries facing related challenges. The development and evaluation of this framework represent a significant step towards improving TVET outcomes and employability on a broader scale.
Deep Learning-Based Image Segmentation Techniques for Bone Fractures Using X-Ray Images: A Systematic Review
Authors: Panhwar Ali Orangzeb , Memon Shahzad , Dhomeja Lachhman Das , Memon Nisar , Chandio Asghar Ali
Published: December 2024

Human bone fractures are common musculoskeletal disorders. The primary cause of fractures is often accidents or external pressure applied to the body, which can result in significant fractures. Medical image processing plays a crucial role in the segmentation and analysis of human bone fractures using X-ray images, assisting physicians in determining appropriate treatments. The use of artificial intelligence (AI) techniques, such as machine learning, deep learning (DL), and transfer learning, has garnered significant interest for medical diagnosis from X-ray image reports. The primary objective of this paper is to explore various deep learning-based methods for analyzing human bones using X-ray images. These methods include the evaluation of U-Net, ViT, TransUnet, Swin-Unet, and Swin-Unet++, with U-Net and SegNet being utilized for comparative analysis. The findings and discussion indicate that U-Net and ViT are among the most promising models for the MURA dataset, achieving high accuracy. A comparison chart is provided in the paper to highlight various fracture segmentation methods, dataset sizes, and evaluation metrics.
CNN-Based Intelligent System for Date Fruit Classification using Novel Dataset
Authors: Khalique Abdul , Shaikh Riaz Ahmed , Arain Rafaqat Hussain , Mujtaba Ghulam
Published: December 2024

The Date fruit is a major crop grown in Middle East. Pakistan was ranked in 5th position in the year 2022 by the Food and Agriculture Organization (FAO). The dates are different from each other due to color, size, texture, and shape with respect to region(or it varies from region to region). The classification, sorting, and separating of date fruit is a crucial process in the industry as manual process is time-consuming, laborious, and inaccurate. A state of art dataset has been used in this research work. for training and testing of models. The Convolutional Neural Network (CNN) based intelligent system based on five date fruit varieties has been proposed. The proposed system classifies five date fruit varieties (Aseel, Dandhi, Fasli Toto, Gajar, and Kupro) efficiently and effectively. In fact, three deep learning models have been trained and tested; each one has achieved a different level of accuracy in terms of five different classes. The novel dataset was collected by the authors of this study to develop proposed system. The highest performance of the proposed system on five different classes were 99.2%, 99.4%, 99.4% and 99.2% for average accuracy, precision, recall and F1-score respectively.
I Desafio Intermodal IFC: uma estratégia de análise de mobilidade urbana
Authors: Raquel Roberta , Geraldo Soares André , Ricardo Godoi Joeci , Shikanai Kerr Daniel
Published: December 2024

A mobilidade urbana é um importante atributo da cidade, no entanto, o atual modelo, baseado no transporte individual motorizado, tem provocado uma série de problemas, tanto de ordens sociais quanto ambientais: congestionamentos, poluição, sinistros, entre outros. Ademais, ao considerarmos que instituições de ensino, a exemplo do Instituto Federal Catarinense (IFC), são Polos Geradores de Viagens (PGV), essa problemática agrava-se ainda mais nessas áreas. Dessa forma, o presente trabalho buscou identificar o meio de deslocamento mais eficiente até o IFC Camboriú. Como metodologia, em parceria com a União de Ciclistas do Brasil (UCB), utilizamos o Desafio Intermodal (DI). O DI surgiu como uma estratégia do movimento social cicloativista para analisar a qualidade da mobilidade urbana, estratégia essa que, ao longo dos anos, foi sendo aprimorada pelo próprio movimento, bem como por pesquisas acadêmicas. No DI, os participantes saem simultaneamente de um mesmo local e devem, cada um com a sua modalidade, chegar no mesmo ponto de destino. O índice de eficiência do DI considera, além do tempo de deslocamento, fatores como: gasto financeiro, emissão de monóxido de carbono, emissão de ruídos e consumo energético. Esta primeira edição do DI IFC Camboriú contou com a participação de 11 pessoas e avaliou a eficiência de 6 modalidades diferentes (bicicleta, moto, carro particular, carro de aplicativo, a pé e ônibus). O resultado do primeiro DI IFC Camboriú chegou a resultados semelhantes aos demais realizados no Brasil e identificou a bicicleta como meio de transporte mais eficiente na mobilidade urbana.
Quantifying Heat Stress using Wet Bulb Globe Temperature measurements during Summer 2024 from Field Experiments in Pune
Authors: Kumar Ravi Ranjan , Tiwari Arpit , Karmakar Ananya , Bankar Ajay , Chattopadhyay Rajib , Hosalikar K. S.
Published: December 2024

Heat stress has emerged as a critical issue amid climate change, particularly in urbanizing areas like India. This study examines heat stress in Pune, focusing on the Wet Bulb Globe Temperature (WBGT) through field experiments conducted during the peak summer months of April and May 2024. The research aimed to understand how urban design, vegetation, and socio-economic factors influence heat stress levels. Three distinct locations: Indian Institute of Science Education and Research (IISER), Fergusson College (FC), and Agriculture College (AGR) were selected to represent varying degrees of urbanization. WBGT meters were installed uniformly at a height of 4 feet to ensure accurate readings, with hourly measurements taken from 9 AM to 6 PM. The highest WBGT index was recorded at FC, the most urbanized site, indicating increased heat stress. Analysis revealed that maximum heat stress typically occurred between 1 PM and 3 PM, with variations depending on the location. The study established WBGT threshold limits for Pune: 31.5°C (90th percentile), 32°C (95th percentile), and 33°C (99th percentile), corresponding to low, moderate, and extreme heat stress levels. Further investigation into meteorological factors showed a strong positive correlation between WBGT and ambient temperature, while relative humidity and wind speed had a reverse correlation. Notably, southerly winds contributed most significantly to heat stress. The study highlights WBGT as a vital metric for assessing heat stress, integrating temperature, humidity, wind speed, and solar radiation. The findings provide essential insights for policymakers, urban planners, and environmentalists, guiding strategies to mitigate the challenges of climate change and enhance urban resilience against heat stress.
Species richness prediction and priority conservation planning for rare Michelia species in China
Authors: Tang Jimin , Chen Zhi , Yin Xiaojie , Teng Jiao , Gao Weijie , Liu Yifei , Li Xiuyu
Published: December 2024

Numerous species are at risk of extinction due to habitat degradation caused by human activity and global warming. Using the optimized MaxEnt and Marxan models, we investigated the relationship between species richness and various factors by predicting the species richness of rare Michelia species based on distribution data and natural ecological factors in China. Additionally, national nature reserves and parks were overlaid with priority conservation zones having irreplaceability values ranging from 80 to 100 to identify conservation gaps. The findings indicate that rare Michelia species are found in southern Yunnan Province, which exhibits the highest concentration. The high richness zones are expected to shrink to 0.62×104km2 under future climate scenarios. Northern high latitudes and higher altitudes are expected to offer better habitats for the majority of rare Michelia species. With the intensification of climate change, it is anticipated that this migration will exceed 150 km. Priority conservation zones for rare Michelia species are primarily located in the southeastern part of the Tibet Autonomous Region, the south-central part of Yunnan Province, the central part of Sichuan Province, the western part of Chongqing Municipality, the southern part of Guizhou Province, the northern part of Guangxi Zhuang Autonomous Region, the southern part of Hunan Province, the northern part of Guangdong Province, the eastern and southern parts of Jiangxi Province, the northwestern part of Fujian Province, the southern part of Zhejiang Province, the central part of Taiwan Province, and the southwestern part of Hainan Province. These priority conservation zones account for only 0.86% of the land area of China, with 6.6×104km2 of prioritized conservation zones not yet designated as nature reserves or parks. To effectively embody the principle that 'green mountains are golden mountains,' we recommend expanding conservation zones for rare Michelia species within designated priority zones and enhancing habitat conservation measures.
The relationship between high serum UA levels and decidualization and angiogenesis in endometrium
Authors: Li Jinran , He Meihua , Huang Min , Xiang Jiahui , Zhang Limei , Liu Yinghui , Ma Yanlin , Zeng Xuhui , Sun Xiaoli
Published: December 2024

Hyperuricemia (HUA) is the second most common metabolic disease after diabetes and refers to a type of disease in which serum uric acid (SUA) levels are excessively high due to excessive production of uric acid (UA) or reduced metabolic capacity. To elucidate the effect of HUA on angiogenesis in endometrial decidualization, the authors investigated endometrial decidualization markers and angiogenesis factors in the decidua after abortion in women with high uric acid levels and the uterus of mice with high uric acid induced by purines on day 7.5 (D7.5) of gestation. Moreover, immunohistochemical staining was used to measure the diameter of the microvascular lumen and the density of the vessels.Real-time PCR and Western blot results showed that the expressions of prolactin (PRL) and decidua/trophoblast PRL-related protein Prl8a2 in the decidua of human decidua and the pregnant uterus of high uric acid mice with D7.5 days of gestation were significantly reduced. Additionally, the diameter and density of the microvascular lumen were decreased by immunohistochemical staining of uterine CD34. The expression of VEGFA in the endometrium was significantly decreased (P < 0.05). High UA can lead to endometrial decidualization damage and angiogenesis disorders in early pregnancy in humans and mice.
The active fault tolerance algorithm design via adaptive sliding mode observer for synchronous motor with stator winding cut and angular velocity sensor faults
Authors: LIU Cong , ，LIU Yongzhi , Bingjie ，FAN
Published: December 2024

The fault tolerance algorithm with adaptive sliding mode observer is provided for the synchronous motor in this paper. First, the nonlinear mathematical model of synchronous motor is built, where multiple faults and electromagnetism nonlinearities are considered simultaneously. Then, an adaptive sliding mode observer for fault reconstruction is designed, where the case of fault information unknown is considered, and the robust fault reconstruction conclusion for the stator winding cut is obtained. Thirdly, the active fault tolerance control law is presented, where the sliding mode control algorithm is added in the law, and the algorithms of d-axis and q-axis control voltage for the motor are provided. Finally numerical and experiment results are presented to demonstrate the effectiveness of the controller proposed in this paper.
The depletion of both TFAM and β-catenin in mitochondria may be associated with mitochondrial dysfunction induced by BoHV-1 productive infection
Authors: Lin Jiayu , Fu Xiaotian , Gu Wenyuan , Li Shitao , Ding Xiuyan , Zhu Liqian
Published: December 2024

Mitochondrial transcription factor A (TFAM), a crucial transcriptional activator of the mitochondrial genome, is synthesized in the cytoplasm and then translocated into mitochondria with the aid of the mitochondrial membrane transport system, which includes key components such as TOM70 and Tim44. BoHV-1 productive infection in cell cultures results in mitochondrial dysfunction with mechanisms poorly understood. In this study, we discovered that TFAM plays a significant role in BoHV-1 productive infection, and later stages of virus infection inhibit mitochondrial biosynthesis, supported by the decreased TFAM accumulation in mitochondria and reduced association of TOM70 and Tim44 proteins with mitochondria. Interestingly, we found that TFAM positively regulates β-catenin protein expression, with a subset of β-catenin residing in mitochondria, where it interacts with TFAM. Moreover, mitochondrial accumulation of β-catenin is reduced following virus infection, which may contribute to decreased mitochondrial biogenesis, as the β-catenin-specific inhibitor iCRT14 reduces the protein expression of Cytb, a key regulator of mitochondrial biosynthesis. Collectively, our findings suggest for the first time that β-catenin signaling may promote mitochondrial biogenesis, and the depletion of both TFAM and p-β-catenin(S552) protein levels in mitochondria may contribute to BoHV-1 productive infection-induced mitochondrial dysfunction.
Determinants of Financial Sustainability of Microfinance Institutions in Ethiopia
Authors: Bedada Dilgasa , Bedada Dilgasa
Published: December 2024

Proletarian of people in mounting countries have been given right to use to formal financial services through microfinance lineups. There is no single definition of the word Financial Sustainability. Therefore, this study was conducted to fill this gap. From the total of thirty four MFIs which are operating in the country and fifteen MFIs have been selected for the study by way of a purposive sampling technique. This study is based on quantitative research approach using statistics panel data analysis and multiple regression model and Audited Financial statement data for eight years are collected by using secondary data from National bank of Ethiopia, from the annual bulletin of AEMFI and mix-market database. The study used STATA version 17.0 to conduct analysis. The study shows that MFIs in Ethiopia at the period financially not self-sufficient. As a result Researcher recommends that to make sustainable MFIs in Ethiopia should have increases yield gross loan portfolio, and inception that increases return on assets habit for in sources then serving the borrower at lower possible expenses and add the value of return on assets rather than grant finance that funding donation from NGOs and regional government and minimize cost per borrower that increases sustainability of Financial Sustainability.
STRUCTURE OF NEMATODE COMMUNITIES ASSOCIATED WITH COWPEA (VIGNA UNGUCULATA, (L) WALP) AS A FUNCTION OF THE PHYSICOCHEMICAL CHARACTERISTICS OF THE SOIL IN THE MARKET GARDENING AREA OF SOTUBA (MALI)
Authors:   Faculty of Science and Technology of USTTB, Mali., Kola Toure Boubacar , Maiga Yacouba ,   Faculty of Science and Technology of USTTB, Mali., Coulibaly Ousmane ,   Faculty of Science and Technology of USTTB, Mali., Issa Larwanou Mamane ,   Student at Ahmed Baba Private University in Bamako, Mali., Maiga Mohamed ,   Faculty of Science and Technology of USTTB, Mali.
Published: December 2024

A nematologicalstudy on cowpea (Vignaunguculata, (L) Walp) wascarried out in 2022 during the rainyseason on the experimental plots of the Sotubaresearch station in Mali. The aim of the studywas to identifyparasiticnematodesassociatedwiththislegume and to assess the influence of soilfactors on the nematofauna. Nematodeswereextractedusing the modified Baermann technique. From the observation of soilsamples, 6 genera of phytonematodeswereidentified:These are Pratylenchus, Tylenchorhynchus, Helicotylenchus, Scutellonema, Meloidogyne and Tylenchus. The generaHelicotylenchus and Tylenchuswere the most important in terms of density and representapproximately 55% of the number of nematodesencountered. The pedologicalanalysisincludingchemical and granulometricparametersshowed an acidictendency of the soil, with a silty-sandy structure. The porosity of suchsoilcouldbe the basis of the distribution of nematodeswhichwerefound to be more abundant in the third plot whichcontains the highest rate of sand 69%. Among the nematodesidentifiedwerespeciesthat are harmful to cowpea, includingMeloidogyne. This study shows the need for phytosanitary monitoring to preventextremeoutbreaksthatcould cause a significant drop in cowpeayields.
INNOVATION IN CYBER THREAT DETECTION: TRANSFORMER-BASED APPROACH
Authors:   Computer Science and Telecommunications Research Laboratory (LARIT)., Bi Dje Guy Gabin Dje ,   Felix HouphouÃ«t-Boigny National Polytechnic Institute, Polytechnic Doctoral School, Engineering Science and Technology, Mathematics and Digital Science, Yamoussoukro. (INPHB, EDP, STI, MSN), Doffou Jerome Diako ,   Computer Science and Telecommunications Research Laboratory (LARIT).,   African Higher School of ICT (ESATIC)., Koffi Kanga ,   Computer Science and Telecommunications Research Laboratory (LARIT).,   African Higher School of ICT (ESATIC)., Souleymane Oumtanaga ,   Computer Science and Telecommunications Research Laboratory (LARIT).,   Felix HouphouÃ«t-Boigny National Polytechnic Institute, Polytechnic Doctoral School, Engineering Science and Technology, Mathematics and Digital Science, Yamoussoukro. (INPHB, EDP, STI, MSN)
Published: December 2024

Malware poses a major threat to cyber security. In fact, its increasing sophistication and rapid spread over the internet poses increasingly complex challenges. Modern malware uses advanced evasion strategies, often rendering traditional detection systems ineffective, especially against zero-day attacks. These challenges are amplified by complex obfuscation techniques, as well as the diversity of malicious behaviors, fueled by the daily creation of new malware. In the face of these threats, our study proposes an innovative approach using BERT and GPT-2 to improve malware detection. The main innovation of our method lies in the application of Transformers to analyze and identify complex behavioral signatures of malware, which improves the detection capability, particularly in terms of accuracy and generalization to new threats. The evaluation of our model on the CICMalDroid2020 dataset, as well as the comparison of the results obtained with similar works, demonstrate that BERT and GPT-2 offer significant advantages in terms of accuracy, robustness and generalization capacity against modern threats.
STUDY ON MOLECULAR MECHANISMS UNDERLYING TUMOUR ANGIOGENESIS
Authors:   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Bhavana Padamata Venkata , Swetha Thotakura Sai ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Kurra Shrinidhi ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Trishanka Veerla Naga ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Chandrika Palapati Ananda ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Kudithipudi Jeeshitha ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Priya Amarthaluri Santhi ,   Department of Biotechnology, Sri Venkateshwara College of Pharmacy, Madhapur, Hyderabad, Telangana, India.
Published: December 2024

Cancer, acomplexdisorder marked by the aberrant proliferation of cells independent of physiological organ connections, represents a multifaceted, multi-stage, and multi-mechanistic phenomenon. Its onset, progression, and manifestation involve intricate interplays between environmental and host factors. Inherited genetic predispositions notably contribute to 5-10 percent of breast cancer and 5-13 percent of colon cancer cases. Within industrialized nations, approximately 7 percent of cancer-related deaths are linked to viral infections, 4 percent to occupational hazards, 2 percent to sunlight exposure, 2 percent to air, water, and soil pollution, and less than 1 percent to constituents in food and industrial products. This review offers a comprehensive examination of ongoing research concerning the micro-metastatic state in solid tumors.
ULTRASOUND APPROACH TO PEDIATRIC RENAL DISORDERS: A PICTORIAL ESSAY
Authors: M. Elsayed Naglaa , Al-Harbi Abdulaziz , Al-Ghamdi Faris , Aldusary Njoud , Abdeen Rawan
Published: December 2024

This research studies the role of Ultrasound in diagnosing pediatric renal disorders and their characteristics. Given the kidneys indispensable functions, accurate diagnosis is paramount, particularly in pediatrics. The study delineates normal pediatric renal Ultrasoundappearance, alongside selected renal disorders. Employing a pictorial essay format, this research presents many high-quality Ultrasound images, aiding in the identification and classification of pediatric renal disorders in a way appropriate for sonographers.
ORAL HYGIENE AWARENESS REGARDING FLOSSING AMONGDENTAL INTERNS: A CROSS-SECTIONAL STUDY
Authors: Jasmin Winnier J. , S. Naik Shilpa , Patil Diksha , Fatima Farooqui Hafsa , Shaikh Hifza
Published: December 2024

Background:Dental floss is an important part of home dental care. It helpsin the maintenance of oral hygiene by effectively cleaning interdental areas, thereby lowering the risk of periodontal diseases and dental caries. The dental professionals have a major role in educating and motivating patients in maintaining oral hygiene. However, use of dental floss among young dental professionals remains unknown.

Aim:To assess knowledge, awareness and selfâ€‘reported practices regarding flossing among dental interns in Navi Mumbai.

Design:A closed-ended15â€‘item questionnairewas formulated and circulated to dental interns through google forms in Navi Mumbai region. A total of 170 responses were obtained during the period from April 2024 to September 2024.

Results:The statistical analysis using mean and average reported that 59.41% participants used dental floss, 27.65% were using it before joining dentistry and only 18.23% used it everyday,80% reported that flossing reduces halitosis, though 34.71% considered that it was not necessary to use,majorly due to lack of awareness.

Conclusion:The study concludes that awareness should be created regarding flossing, and adequate training should be imparted to young dental professionals. Along with itrecommended home dental care should also be practiced in order to act as role models for the general population and to increase the prescription practices.
PHYTOCHEMICAL STUDY AND EVALUATION OF THE ANTIOXIDANT ACTIVITIES OF LEAVES FROM VERNONIAAMYGDALINA
Authors:   UFR des Sciences et Technologies, Universite Alassane Ouattara (UAO)., Axel Adou Demel ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Pierre Alain Konan Kouassi ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Brice Bredou Jean ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Alette Edwige Ziale Djele ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Severin Katou Yapo ,   UFR des Sciences et Technologies, Universite Alassane Ouattara (UAO).,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Akhanovna Mamyrbekova-Bekro Janat ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA)., Yves-Alain Bekro ,   Laboratoire de Chimie Bio-Organique Et de Substances Naturelles, UFR des Sciences Fondamentales et Appliquees, Universite NanguiAbrogoua (UNA).
Published: December 2024

The aim of this study is to highlight the phytochemical composition and antioxidant potential of the ethereal extract of the leaves of Vernoniaamygdalina, a plant used in traditional medicine in CÃ´te dIvoire.Phytochemical studies using TLC and LC-MS revealed, in addition to coumarins, flavonoids and phenolic acids. Determination of the antioxidant potential by TLC and spectrophotometry using the DPPH radical showed the antioxidant power of Vernoniaamygdalina leaves with a CR50 of 0.01995 Â± 0.2x10-5 % mg/mL.The many pharmacological properties of V. amygdalina would therefore depend on the coexistence of these phytocompounds.
MANAGEMENT OF SEVERE BALLISTIC THORACIC TRAUMA: A CASE REPORT AND REVIEW OF CURRENT PRACTICES
Authors:   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco., Ali Grine , Amine Belghiti ,   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco., Mohamed Bhiris ,   Thoracic surgery Department, Mohammed V Military Teaching Hospital, Rabat, Morocco., Hamza Najout ,   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco., Khalil Mounir ,   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco., Abdelhamid Jaafari ,   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco., Hicham Balkhi ,   Surjical Intensive Care Unit, Department of Anesthesia and Critical Care, Mohammed V Military Teaching Hospital, Rabat, Morocco.
Published: December 2024

Ballistic thoracic trauma represents a severe medical emergency, characterized by high rates of morbidity and mortality. These injuries typically occur in the context of interpersonal violence or firearm-related accidents and are associated with significant damage to thoracic structures, including the lungs, major blood vessels, and mediastinum. Effective management of such trauma relies on the rapid recognition of clinical signs, followed by prompt interventions to prevent potentially fatal complications such as massive hemothorax or respiratory distress. This case report describes the management of a 22-year-old man who sustained severe ballistic thoracic trauma. Upon admission, the patient presented with a massive hemothorax, mediastinal shift, and signs of acute respiratory decompensation. Following initial evaluation and partial stabilization, an emergency intervention consisting of thoracic drainage was performed on-site, leading to a rapid improvement in the patients clinical condition. The objective of this work is to highlight the importance of on-site interventions in the management of severe thoracic injuries, emphasizing the challenges faced in resource-limited settings and reviewing current recommendations for the management of ballistic thoracic trauma.