bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidant-directed chemoselective sulfonylation and sulfonyloximation of alkenes via cleaving the C–S bond in TosMIC
Authors: Chu Xue-Qiang , Ge Danhua , Loh Teck-Peng , Shen Zhi-Liang
Published: February 2019

Oxidant-directed chemoselective sulfonylation and sulfonyloximation reactions for the divergent synthesis of valuable vinyl sulfones and α-sulfonylethanone oximes are developed.
Mechanistic insights into intermolecular cyclization of ring-fused benzocyclobutenols with alkynes catalyzed by [{Ir(OMe)COD}2]
Authors: Zhao Yang , Wang Ping , Gao Yun , Zhu Chen , Liu Wei , Wang Yong
Published: February 2019

A mechanism study of iridium-catalyzed intermolecular cyclization of ring-fused benzocyclobutenols with alkynes is described using density functional theory (DFT).
A fluorescent biosensor for cardiac biomarker myoglobin detection based on carbon dots and deoxyribonuclease I-aided target recycling signal amplification
Authors: Chen Jishun , Ran Fengying , Chen Qinhua , Luo Dan , Ma Weidong , Han Tuo , Wang Ceming , Wang Congxia
Published: February 2019

A sensitive biosensor has been developed to detect myoglobin (MB), which is an important cardiac biomarker and plays a major role in the diagnosis of acute myocardial infarction (AMI).
Preparation and characterization of a novel positively charged composite hollow fiber nanofiltration membrane based on chitosan lactate
Authors: He Yuantao , Miao Jing , Chen Shunquan , Zhang Rui , Zhang Ling , Tang Haolin , Yang Hao
Published: February 2019

A positively charged composite hollow fiber nanofiltration (NF) membrane was prepared via interfacial polymerization by using chitosan lactate and trimesoyl chloride (TMC).
Improved dielectric stability of epoxy composites with ultralow boron nitride loading
Authors: Fu Xiuwu , Guo Yiping , Du Qi , Guan Lin , He Sibo
Published: February 2019

3D BN/PA66 aerogels are prepared for the first time by the freeze-drying and improve dielectric stability of the composites.
The stability enhancement factor beyond eight-electron shell closure in thiacalix[4]arene-protected silver clusters
Authors: Guan Zong-Jie , Hu Feng , Yuan Shang-Fu , Nan Zi-Ang , Lin Yu-Mei , Wang Quan-Ming
Published: February 2019

Destroying coordination open sites may significantly enhance the stability of metal nanoclusters.
Nickel-catalyzed oxidative C–H/N–H annulation of N-heteroaromatic compounds with alkynes
Authors: Obata Atsushi , Sasagawa Akane , Yamazaki Ken , Ano Yusuke , Chatani Naoto
Published: February 2019

The reaction of N-heteroaromatic compounds, such as 2-aryl-pyrrole, benzimidazole, imidazole, indole, and pyrazole derivatives, with alkynes in the presence of a catalytic amount of a nickel complex results in C–H/N–H oxidative annulation.
Stereoselective synthesis of alkyl-, aryl-, vinyl- and alkynyl-substituted Z-enamides and enol ethers
Authors: Caramenti Paola , Declas Nina , Tessier Romain , Wodrich Matthew D. , Waser Jerome
Published: February 2019

Highly stereoselective synthesis of Z-enamides and enol ethers at room temperature via an umpolung/cross coupling strategy applicable to drugs and natural products.
Disordered surface formation of WS2via hydrogen plasma with enhanced anode performances for lithium and sodium ion batteries
Authors: Wang Hongmei , Yuan Qian , Wang Dong , Chen Ge , Cheng Xing , Kups Thomas , Schaaf Peter
Published: February 2019

This article presents hydrogenated WS2 nanoparticles which demonstrated clearly enhanced electrochemical performances as anode materials for both lithium and sodium ion batteries.
A stochastic model for bacteria-driven micro-swimmers
Authors: Esparza López Christian , Théry Albane , Lauga Eric
Published: February 2019

We derive analytical expressions for the diffusion coefficient and the chemotactic drift velocity of bacteria-driven micro-swimmers.
Drying-induced stresses before solidification in colloidal dispersions: in situ measurements
Authors: Bouchaudy Anne , Salmon Jean-Baptiste
Published: February 2019

We report an original setup that enables continuous measurements of stresses induced by the drying of confined drops of complex fluids.
Effects of strain-dependent surface stress on the adhesive contact of a rigid sphere to a compliant substrate
Authors: Liu Zezhou , Jensen Katharine E. , Xu Qin , Style Robert W. , Dufresne Eric R. , Jagota Anand , Hui Chung-Yuen
Published: February 2019

Finite element is used to simulate the adhesive contact of a rigid sphere on a soft substrate. By including large deformation and strain-dependent surface stress, our prediction agrees much better with experiments, providing support to the existence of strain-dependent surface stress.
Ordered platinum–bismuth intermetallic clusters with Pt-skin for a highly efficient electrochemical ethanol oxidation reaction
Authors: Zhang Bin-Wei , Lai Wei-Hong , Sheng Tian , Qu Xi-Ming , Wang Yun-Xiao , Ren Long , Zhang Lei , Du Yi , Jiang Yan-Xia , Sun Shi-Gang , Dou Shi-Xue
Published: February 2019

A monatomic Pt layer (Pt-skin) on ordered intermetallic PtBi clusters (PtBi@Pt) supported on graphene is fabricated via a single atom self-assembling (SAS) method to form a superior catalyst toward electrochemical ethanol oxidation reaction.
Binary NiCoO2-modified graphite felt as an advanced positive electrode for vanadium redox flow batteries
Authors: Xiang Yan , Daoud Walid A.
Published: February 2019

A novel approach of employing binary NiCoO2 modified graphite felt as an advanced positive electrode in vanadium redox flow batteries is presented.
Single-crystal based studies for correlating the properties and high-voltage performance of Li[NixMnyCo1−x−y]O2 cathodes
Authors: Zhu Jian , Chen Guoying
Published: February 2019

Particle surface design is shown to be essential in optimizing the performance and stability of NMC-type LIB cathode materials.
A redox stable Pd-doped perovskite for SOFC applications
Authors: Marcucci Andrea , Zurlo Francesca , Sora Isabella Natali , Placidi Ernesto , Casciardi Stefano , Licoccia Silvia , Di Bartolomeo Elisabetta
Published: February 2019

La0.6Sr0.4Fe0.95Pd0.05O3−δ shows a reversible crystal structure and exhibits improved performance and redox stability when used as electrode in SOFCs.
Massively enhanced ionic transport in irradiated crystalline pyrochlore
Authors: Kreller Cortney R. , Valdez James A. , Holesinger Terry G. , Morgan Jonathan , Wang Yongqiang , Tang Ming , Garzon Fernando H. , Mukundan Rangachary , Brosha Eric L. , Uberuaga Blas P.
Published: February 2019

The conductivity of Gd2Ti2O7 with irradiation-induced structural disorder increased with disorder as the material transformed from ordered pyrochlore to defect-fluorite.
Construction of mesoporous Cu-doped Co9S8 rectangular nanotube arrays for high energy density all-solid-state asymmetric supercapacitors
Authors: Lu Wen , Yuan Ze , Xu Chunyang , Ning Jiqiang , Zhong Yijun , Zhang Ziyang , Hu Yong
Published: February 2019

A self-templating strategy was used to prepare novel mesoporous Cu-doped Co9S8 rectangular nanotube arrays (Cu-Co9S8 NTAs) as an advanced electrode for all-solid-state asymmetric supercapacitors, which deliver a high energy density of 71.93 W h kg−1 at a power density of 750 W kg−1.
Eu2SrCo1.5Fe0.5O7 a new promising Ruddlesden–Popper member as a cathode component for intermediate temperature solid oxide fuel cells
Authors: Boulahya Khalid , Muñoz-Gil Daniel , Gómez-Herrero Adrián , Azcondo M. Teresa , Amador Ulises
Published: February 2019

A new oxide of the Ruddlesden–Popper series in the (Eu,Sr)n+1(Co,Fe)nO3n+1 system has been isolated and structurally characterized.
Rapid synthesis of ultrathin 2D materials through liquid-nitrogen and microwave treatments
Authors: Zhu Xingwang , Yang Jinman , She Xiaojie , Song Yanhua , Qian Junchao , Wang Yan , Xu Hui , Li Huaming , Yan Qingyu
Published: February 2019

A new universal and rapid method to exfoliate bulk layered materials into ultrathin 2D structures with thicknesses of less than 5 nm through liquid-nitrogen and microwave treatments.
Nb-Doped titanium phosphate for sodium storage: electrochemical performance and structural insights
Authors: Voronina Natalia , Jo Jae Hyeon , Choi Ji Ung , Jo Chang-Heum , Kim Jongsoon , Myung Seung-Taek
Published: February 2019

Novel Nb5+-doped titanium phosphate is developed and used as both the cathode and anode to realize superior sodium-ion storage.
Hollow carbon nanospheres derived from biomass by-product okara for imaging-guided photothermal therapy of cancers
Authors: Weng Yangziwan , Guan Shanyue , Wang Li , Qu Xiaozhong , Zhou Shuyun
Published: February 2019

Okara, a byproduct of soymilk or tofu production, was used to prepare hollow carbon nanospheres with excellent photothermal conversion efficiency and photoacoustic responsiveness, which were tested as imaging-guided PTT agents for cancer treatment.
Design and synthesis of a fluorescent amino poly(glycidyl methacrylate) for efficient gene delivery
Authors: Chen Hongtao , You Shusen , Cai Qing , Zheng Yang , Zhang Liqun , Shen Jie , Yin Meizhen
Published: February 2019

A fluorescent amino poly(glycidyl methacrylate) (PGOHMA) was synthesized by atom transfer radical polymerization (ATRP) and post-polymerization. PGOHMA has low cytotoxicity and high DNA delivery efficiency.
A polyoxometalate-modified magnetic nanocomposite: a promising antibacterial material for water treatment
Authors: Fang Yan , Xing Cuili , Zhan Shixia , Zhao Meng , Li Mingxue , Liu Hongling
Published: February 2019

A polyoxometalate-modified magnetic nanocomposite integrates the double antibacterial effects of both Fe3O4 and polyoxometalate, rendering it a promising candidate as an antimicrobial material.
First principles based screen for identification of transparent conductors
Authors: Li Yuwei , Singh David J.
Published: February 2019

We present methods for screening semiconductors as transparent conductors leading to a simple application dependent fitness function.
Thiourea dioxide as a source of sulfonyl groups: photoredox generation of sulfones and sulfonamides from heteroaryl/aryl halides
Authors: Ye Shengqing , Li Yuewen , Wu Jie , Li Zhiming
Published: February 2019

Thiourea dioxide is applied as the source of sulfonyl groups for the efficient synthesis of heteroaryl sulfones and sulfonamides from heteroaryl halides under visible light irradiation. This transformation proceeds through a radical process via heteroaryl sulfinate intermediates, as supported by EPR spectroscopy and DFT calculations.
Selective reduction of 1,5-diazacyclooctatetraenes: synthesis and structures of aromatic diazacyclooctatetraenyl dianions and a 2,6-bipyrrolinyl dianionic Co(ii) complex
Authors: Huang Zhe , Tan Gengwen , Chen Chao , Zhang Wen-Xiong , Wang Xinping , Xi Zhenfeng
Published: February 2019

The first structurally well-defined aromatic 1,5-diazacyclooctatetraenyl dianion and a 2,6-bipyrrolinyl dianionic Co(ii) complex were obtained selectively via reduction of 1,5-diazacyclooctatetraenes.
Charge reversal induced colloidal hydrogel acts as a multi-stimuli responsive drug delivery platform for synergistic cancer therapy
Authors: He Gang , Chen Sheng , Xu Yunjun , Miao Zhaohua , Ma Yan , Qian Haisheng , Lu Yang , Zha Zhengbao
Published: February 2019

A charge reversal induced colloidal hydrogel composed of amphoteric gelatin nanoparticles (Gela NPs) and melanin-like polydopamine nanoparticles (PDA NPs) was developed for synergistic cancer therapy.
Xerogel activated diatoms as an effective hybrid adsorbent for the efficient removal of malachite green
Authors: Sriram Ganesan , Uthappa U. T. , Kigga Madhuprasad , Jung Ho-Young , Altalhi Tariq , Brahmkhatri Varsha , Kurkuri Mahaveer D.
Published: February 2019

The surface of a naturally available diatom was modified using a xerogel for the enhanced removal of malachite green from aqueous media.
The influence of the Si/Al ratio of Mo/HZSM-5 on methane non-oxidative dehydroaromatization
Authors: Zhao Keke , Jia Litao , Wang Jungang , Hou Bo , Li Debao
Published: February 2019

MoO22+ exists for the low Si/Al ratio catalysts and (Mo2O5)2+ for the high Si/Al ratio catalysts.
Highly efficient biocatalytic desymmetrization of meso carbocyclic 1,3-dicarboxamides: a versatile route for enantiopure 1,3-disubstituted cyclohexanes and cyclopentanes
Authors: Hu Hui-Juan , Chen Peng , Ao Yu-Fei , Wang Qi-Qiang , Wang De-Xian , Wang Mei-Xiang
Published: February 2019

Highly efficient biocatalytic desymmetrization of meso carbocyclic 1,3-dicarboxamides to enantiopure 1,3-disubstituted cyclohexanes and cyclopentanes was realized.
In situ polymerization and FT-IR characterization of poly-glycine on pencil graphite electrode for sensitive determination of anti-emetic drug, granisetron in injections and human plasma
Authors: Ali Marwa F. B. , Abdel-aal Fatma A. M.
Published: February 2019

In situ polymerization is a simple and efficient technique for modification and fabrication of modified electrodes in voltammetry.
Bioinspired transfer method for the patterning of multiple nanomaterials
Authors: Wang Xuan , Gao Bingbing , Gu Zhongze
Published: February 2019

Patterned nanomaterials have promising applications in various fields, particularly for microfluidic analysis and functional surfaces.
Photo-responsive cyclodextrin/anthracene/Eu3+ supramolecular assembly for a tunable photochromic multicolor cell label and fluorescent ink
Authors: Zhou Weilei , Chen Yong , Yu Qilin , Li Peiyu , Chen Xuman , Liu Yu
Published: February 2019

A photoresponsive supramolecular assembly was constructed and presented multi-color fluorescence emissions in several environments including solution, PVA and living cells.
Triggering highly stable catalytic activity of metallic titanium for hydrogen storage in NaAlH4 by preparing ultrafine nanoparticles
Authors: Zhang Xin , Ren Zhuanghe , Zhang Xuelian , Gao Mingxia , Pan Hongge , Liu Yongfeng
Published: February 2019

Ultrafine Ti nanoparticles (3–5 nm) supported on amorphous carbon are prepared as a highly active catalyst for hydrogen storage in NaAlH4.
Tunable negative permittivity and magnetic performance of yttrium iron garnet/polypyrrole metacomposites at the RF frequency
Authors: Cheng Chuanbing , Fan Runhua , Fan Guohua , Liu Hu , Zhang Jiaoxia , Shen Jianxing , Ma Qian , Wei Renbo , Guo Zhanhu
Published: February 2019

Tunable negative permittivity and relaxation-type dispersion for permeability were evidenced in yttrium iron garnet/polypyrrole metacomposites.
Substrate-assisted mechanism of catalytic hydrolysis of misaminoacylated tRNA required for protein synthesis fidelity
Authors: Ilchenko Mykola M. , Rybak Mariia Yu. , Rayevsky Alex V. , Kovalenko Oksana P. , Dubey Igor Ya. , Tukalo Michael A.
Published: February 2019

d-aminoacyl-tRNA-deacylase (DTD) prevents the incorporation of d-amino acids into proteins during translation by hydrolyzing the ester bond between mistakenly attached amino acids and tRNAs. Despite extensive study of this proofreading enzyme, the precise catalytic mechanism remains unknown. Here, a combination of biochemical and computational investigations has enabled the discovery of a new substrate-assisted mechanism of d-Tyr-tRNATyr hydrolysis by Thermus thermophilus DTD. Several functional elements of the substrate, misacylated tRNA, participate in the catalysis. During the hydrolytic reaction, the 2′-OH group of the А76 residue of d-Tyr-tRNATyr forms a hydrogen bond with a carbonyl group of the tyrosine residue, stabilizing the transition-state intermediate. Two water molecules participate in this reaction, attacking and assisting ones, resulting in a significant decrease in the activation energy of the rate-limiting step. The amino group of the d-Tyr aminoacyl moiety is unprotonated and serves as a general base, abstracting the proton from the assisting water molecule and forming a more nucleophilic ester-attacking species. Quantum chemical methodology was used to investigate the mechanism of hydrolysis. The DFT-calculated deacylation reaction is in full agreement with the experimental data. The Gibbs activation energies for the first and second steps were 10.52 and 1.05 kcal/mol, respectively, highlighting that the first step of the hydrolysis process is the rate-limiting step. Several amino acid residues of the enzyme participate in the coordination of the substrate and water molecules. Thus, the present work provides new insights into the proofreading details of misacylated tRNAs and can be extended to other systems important for translation fidelity.
C-reactive protein for predicting all-cause mortality in patients with acute ischemic stroke: a meta-analysis
Authors: Yu Bo , Yang Ping , Xu Xuebi , Shao Lufei
Published: February 2019

Studies on the association of C-reactive protein (CRP) with all-cause mortality in acute ischemic stroke patients have yielded conflicting results. The objective of this meta-analysis was to evaluate the prognostic value of CRP elevation in predicting all-cause mortality amongst patients with acute ischemic stroke. We searched the original observational studies that evaluated the association of CRP elevation with all-cause mortality in patients with acute ischemic stroke using PubMed and Embase databases until 20 January 2018. Pooled multivariate-adjusted hazard ratio (HR) with 95% confidence intervals (CI) of all-cause mortality was obtained for the highest compared with the lowest CRP level or per unit increment CRP level. A total of 3604 patients with acute ischemic stroke from eight studies were identified. Acute ischemic stroke patients with the highest CRP level were independently associated with an increased risk of all-cause mortality (HR: 2.07; 95% CI: 1.60–2.68) compared with the lowest CRP category. The pooled HR of all-cause mortality was 2.40 (95% CI: 1.10–5.21) for per unit increase in log-transformed CRP. Elevated circulating CRP level is associated with the increased risk of all-cause mortality in acute ischemic stroke patients. This meta-analysis supports the routine use of CRP for the death risk stratification in such patients.
What Is Meant by “Multimodal Therapy” for Aphasia?
Authors: Pierce John E. , O'Halloran Robyn , Togher Leanne , Rose Miranda L.
Published: February 2019

Purpose

Multimodal therapy
is a frequent term in aphasia literature, but it has no agreed upon definition. Phrases such as “multimodal therapy” and “multimodal treatment” are applied to a range of aphasia interventions as if mutually understood, and yet, the interventions reported in the literature differ significantly in methodology, approach, and aims. This inconsistency can be problematic for researchers, policy makers, and clinicians accessing the literature and potentially compromises data synthesis and meta-analysis. A literature review was conducted to examine what types of aphasia treatment are labeled
multimodal
and determine whether any patterns are present.

Method

A systematic search was conducted to identify literature pertaining to aphasia that included the term
multimodal therapy
(and variants). Sources included literature databases, dissertation databases, textbooks, professional association websites, and Google Scholar.

Results

Thirty-three original articles were identified, as well as another 31 sources referring to multimodal research, all of which used a variant of the term
multimodal therapy
. Treatments had heterogeneous aims, underlying theories, and methods. The rationale for using more than 1 modality was not always clear, nor was the reason each therapy was considered to be multimodal when similar treatments had not used the title. Treatments were noted to differ across 2 key features. The 1st was whether the ultimate aim of intervention was to improve total communication, as in augmentative and alternative communication approaches, or to improve 1 specific modality, as when gesture is used to improve word retrieval. The 2nd was the point in the treatment that the nonspeech modalities were employed.

Discussion

Our review demonstrated that references to “multimodal” treatments represent very different therapies with little consistency. We propose a framework to define and categorize multimodal treatments, which is based both on our results and on current terminology in speech-language pathology.

Video Abstract and Supplemental Material

https://doi.org/10.23641/asha.7646717
Speech-Language Pathology and the Youth Offender: Epidemiological Overview and Roadmap for Future Speech-Language Pathology Research and Scope of Practice
Authors: Snow Pamela C.
Published: February 2019

Purpose

This article is concerned with the growing body of international evidence indicating that adolescents in contact with the youth justice system are likely to have severely compromised oral language skills, receptively and expressively. A smaller, but persuasive, literature also points to poor literacy skills in this population. Language and literacy skills underpin academic, social, and vocational success (C. Snow, 1983;P. C. Snow, 2016;Snowling & Hulme, 2012) and are central to the professional expertise of speech-language pathology as a profession (P. C. Snow, 2016).

Method

In this article, I review the epidemiology of youth offending together with research evidence concerning the language and literacy skills of this population. I outline the major practice and research implications of these findings for speech-language pathology as a profession, considering the “school-to-prison pipeline” via key domains of early years' reading instruction, young people's passage through the justice system, restorative justice processes, and design and delivery of language and literacy interventions for young people on youth justice orders.

Results

Implications for speech-language pathology scope of practice and future research are outlined.

Conclusions

Speech-language pathology as a profession has a significant role to play in advocating for vulnerable young people at each point in the school-to-prison pipeline. This includes strengthening the evidence base concerning speech-language pathology language and literacy interventions and lobbying governments to fund speech-language pathology services to address the complex communication needs of this population, both on community-based and custodial orders.
Variable emission mechanism of a Type IV radio burst
Authors: Morosan D. E. , Kilpua E. K. J. , Carley E. P. , Monstein C.
Published: February 2019

Context. The Sun is an active star and the source of the largest explosions in the solar system, such as flares and coronal mass ejections (CMEs). Flares and CMEs are powerful particle accelerators that can generate radio emission through various emission mechanisms.

Aims. CMEs are often accompanied by Type IV radio bursts that are observed as continuum emission in dynamic spectra at decimetric and metric wavelengths, but their emission mechanism can vary from event to event. Here, we aim to determine the emission mechanism of a complex Type IV burst that accompanied the flare and CME on 22 September 2011.

Methods. We used radio imaging from the Nançay Radioheliograph, spectroscopic data from the e-Callisto network, ARTEMIS, Ondrejov, and Phoenix3 spectrometers combined with extreme-ultraviolet observations from NASA’s Solar Dynamic Observatory to analyse the Type IV radio burst and determine its emission mechanism.

Results. We show that the emission mechanism of the Type IV radio burst changes over time. We identified two components in the Type IV radio burst: an earlier stationary Type IV showing gyro-synchrotron behaviour, and a later moving Type IV burst covering the same frequency band. This second component has a coherent emission mechanism. Fundamental plasma emission and the electron-cyclotron maser emission are further investigated as possible emission mechanisms for the generation of the moving Type IV burst.

Conclusions. Type IV bursts are therefore complex radio bursts, where multiple emission mechanisms can contribute to the generation of the wide-band continuum observed in dynamic spectra. Imaging spectroscopy over a wide frequency band is necessary to determine the emission mechanisms of Type IV bursts that are observed in dynamic spectra.
Carbon12C/13C isotope ratio ofαAurigae revised
Authors: Sablowski Daniel P. , Järvinen Silva , Ilyin Ilya , Strassmeier Klaus G.
Published: February 2019

Context. Capella (αAur) is one of the few binaries in the sky with two cool giant stars. With spectral types of G8III and G0III, the two components appear at different but distinct stages in their evolution. The G0 secondary star is a Hertzsprung-gap giant, and the G8 primary star is thought to be a clump giant.

Aims. We present a new measure of the carbon12C/13C isotope ratio of the primary component of Capella using high-resolutionR ≈ 250 000 spectra obtained with the Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) with both the Vatican Advanced Technology Telescope (VATT) and the Large Binocular Telescope (LBT).

Methods. Signal-to-noise ratios of up to 2 700 were obtained by averaging nightly spectra. These average spectra were used to disentangle the two binary components. The isotope ratio was derived with the use of spectrum synthesis from the CN lines at 8004 Å.

Results. We found that the12C/13C ratio of the primary component of Capella is 17.8 ± 1.9. Our measurement precision is now primarily limited by the spectral-line data and by the grid-step size of the model atmospheres rather than the data. The separated spectrum of the secondary component does not show distinguishable12CN and13CN lines because of itsvsiniand higher temperature.

Conclusions. Our new12C/13C value is significantly lower than the previous value of 27 ± 4 but now agrees better with the recent model prediction of 18.8–20.7.
Exergy Analysis of Liquid Nitrogen Power Cycles
Authors: Wojcieszak Paweł
Published: February 2019

Nitrogen is by-product from cryogenic air separation processes used for oxygen production for metallurgy and oxygen-enriched combustion purposes. If the gases are delivered from air separation unit (ASU) in liquid phase, liquid nitrogen (LN2) can be used as energy accumulator for stabilization of electrical grid system with large share of renewable energy sources. When the energy demand is high and not enough electricity is generated in power plants, energy accumulated inLN2may be recovered in a cryogenic power cycle. In this research complete exergy analysis of liquid nitrogen direct expansion cycle and combined direct expansion/Brayton cycle was performed.
Abnormal behaviour of the resistive transition to the normal state in superconducting Nb-Ti tapes just below Hc2
Authors: Guryev Valentin , Shavkin Sergey , Irodova Alla , Kruglov Vitaliy
Published: February 2019

The results of studying the resistive properties of Nb-Ti tapes in high magnetic fields close to the upper critical field (Hc2) are reported. The voltage-current curves (VCCs) and resistance-current cures (RCCs) show an “abnormal” hysteresis which is opposite in sign to a common thermal one caused by self-heating. Several features were noted: the existence of threshold current below which VCCs are reversible and the presence of excessive voltage noise in the hysteresis region. Earlier the similar behaviour was observed in granular superconductors. The nature of the “granular” properties of Nb-Ti tapes in high magnetic field and the relation with other observed effects, such as the irreversibility field and the apparent anisotropy of the upper critical field are discussed.
Higgs boson production in association with a single top quark at the LHC
Authors: Koval Oksana A. , Boyko Igor R. , Huseynov Nazim
Published: February 2019

Higgs boson production in association with a single top quark is the only process sensitive to the sign of the Top Yukawa coupling. We present a Monte-Carlo study of the pp → tHqb process and discuss the esperimental signatures that can help to discover it at the LHC. Two scenarios have been considered, the Standard Model case and the Inverted Top Coupling scenario.
Deuteron beam polarization measurement at 270 MeV at Nuclotron internal target
Authors: Skhomenko Ya.T. , Ladygin V.P. , Gurchin Yu.V. , Isupov A.Yu. , Janek M. , Karachuk J.T. , Khrenov A.N. , Kurilkin P.K. , Livanov A.N. , Piyadin S.M. , Reznikov S.G. , Terekhin A.A. , Tishevsky A.V. , Averyanov A.V. , Belov A.S. , Chernykh E.V. , Enache D. , Fimushkin V.V. , Krivenkov D.O. , Vnukov I.E. , Volkov I.S.
Published: February 2019

The current deuteron beam polarimetry at Nuclotron is provided by the Internal Target polarimeter based on the use of the asymmetry in dp-elastic scattering at large angles in the cms at 270 MeV. The upgraded deuteron beam polarimeter has been used to obtain the vector and tensor polarization during 2016 runs for the DSS experimental program. The polarimeter has been used also for tuning of the polarized ion source parameters for 6 different spin modes. The data analysis has been performed using developed software based on C++ language and ROOT5 library.
Cloud infrastructure of INP’S Astana branch - PE “NULITS” and its integration with distributed JINR cloud infrastructure
Authors: Mazhitova Yelena , Balashov Nikita , Baranov Aleksandr , Kutovskiy Nikolay , Semenov Roman , Potapchuk Boris
Published: February 2019

The article describes the Institute of Nuclear Physics’ (INP) Astana branch - private establishments “Nazarbayev University Library and IT services” (PE NULITS) cloud and its integration with the distributed cloud infrastructure consisting of the Laboratory of Information Technologies of the Joint Institute for Nuclear Research (JINR) cloud as well as clouds of some JINR Member State organizations. It explains a motivation of that work, an approach it is based on, working plan of the integration.
Simulations of the impact of small details on the magnetic fileld distribution for the compact superconducting cyclotron SC200 commissioning
Authors: Popov Dmitry , Karamyshev Oleg , Karamysheva Galina , Malinin Vladimir , Shirkov Grigori
Published: February 2019

Modern packages for the design and simulation of cyclotron magnet systems, such as Tosca, CST Studio, Comsol, etc., combined with recent hardware of high performance, allow us to simulate and estimate even a subtle impact on the magnetic field distribution caused by small details and other systems of the accelerator. Such reckoning provides the data to perform and simulate the refilnement of the magnet called the ‘shimming’. That means a signifilcant part of the commissioning stage could be done in ‘virtual reality’. This could substantially decrease the duration of the shimming procedure of the real magnet and the amount of the material wasted on it, eventually this results in a fileld of high-precision which could be compared to real one.
Two-component Dark Matter in the vectorlike hypercolor extension of the Standard Model
Authors: Beylin Vitaly , Bezuglov Maxim , Kuksa Vladimir
Published: February 2019

We consider a minimal vectorlike extension of the Standard Model that naturally contains two types of stable neutral particles. They can be interpreted as the Dark Matter candidates. Here, the SM is supplemented by a new fermion (H-quark) sector that is in confilnement providing by the SU(2)HC gauge group. H-quarks interact with the SM particles via standard electroweak bosons. In analogy with the conventional QCD, H-quarks can form bound states, H-hadrons, that emerge in the σ− model framework. Along with the stable neutral H-pion, there is one more pseudo-goldstone (diquark) state, B0, which is stable and also can be a component of the DM. Mass splittings both for components of the H-pion triplet and for neutral H-pion and B0 have been calculated, it is shown that this splittings can be small. The relic abundance for this composition of the DM is analyzed as well as the DM particles scattering off nucleons. A feature of this scenario is that Dark Matter turns out to consist of particles which are close in mass but have different origin and interact differently with ordinary matter. So, the model predicts two-component structure of the DM together with some specifilc manifestations of it.
Reception of Modulated Neutrino Day-Night Effect Signal by Neutrino Detectors
Authors: Kharlanov Oleg
Published: February 2019

The regeneration effect of solar neutrinos in the Earth leading to the so-called day-night effect strongly depends on the neutrino energy, the time of day, and the season. Classical neutrino experiments, such as Super-Kamiokande, typically observe this effect cumulatively, i.e., virtually integrate it over the year. We discuss various day-night effects that could become potentially observable if time-weighted data processing is applied to neutrino events. The procedure is similar to reception of radio-frequency modulated signals and ‘demodulation’ of the neutrino signal, for example, is able to reveal interesting signatures in the high-energy tail of the electron recoil energy spectrum
On the Development and Present Situation of Medical Education in China
Authors: Zhu Haidong , Gao Jialin
Published: February 2019

Under the background of economic globalization, carrying out medical education is of great significance for improving the level of medical education of the country. The development of medical education in China has entered a new stage of development. How to realize the integration of medical education with international standards is a question that is worth thinking. Of course, it is a long process to realize the internationalization of medical education, which requires constant persistence and improvement. While drawing on international advanced experience, we should also explore the form of medical education in China and take the international road that is most suitable for the development of medical education in China.
Formal Analysis and Application of the New Mode of "VR+ Education"
Authors: Meng Xiangyu
Published: February 2019

"VR+ education" is the development trend of educational technology in the future. Aiming at the difficult problem of combining virtual reality technology with educational technology, and based on the purpose of adapting to the future development needs, this paper uses formal logic method to analyze the promotion conditions of "VR+education", and puts forward the application strategies and impact evaluation, which can provide reference for the practical application of the new model in the field of teaching.
Experimental Verification of Gene Expression Related to Lung Cancer in Nasal Epitthelia
Authors: Huang Qianwen , Qureshi Noman , Lin Simin , Duan Shaoyin
Published: February 2019

Genes expression related to lung cancer are observed in nasal epitthelia, to identify their similarities and differences and provide the basis for possible application. There are three groups:non-lung cancer group (NLC), lung cancer group (LC) and postoperative lung cancer group (PLC).The genes expression in nasal epitthelia were observed by PCR, including the HCK, NCF1, TLR8, EMR3, CSF2RB, DYSF, SPEF2, ANKFN1, HYDIN, DNAH5, C12orf55 and CCDC113. Their expression levels were obtained and statistically compared. Results showed that all the related genes in LC and PLC groups were highly expressed. There are significant difference in HCK, NCF1, TLR8, EMR3, CSF2RB and C12orf55 gene expression between the LC or PLC and NLC, and in EMR3 and C12orf55 between LC and PLC. Conclusions are HCK, NCF1, TLR8, EMR3, CSF2RB, C12orf55 can be used for lung cancer screening, while EMR3 and C12orf55 for the review of post-operative lung cancer.
Application of Information Engineering in Hospital Management
Authors: Wang Na , Wang Jinguo
Published: February 2019

In order to realize cross-hospital data sharing and solve the problem of system interconnection, an information service platform was set up to build homogeneity of the core system, unify the basic standard, and recreate the business process, so as to achieve integration of multiple hospital systems. The system integration of thi information service platform realizes the interconnection and interworking of the systems of the two chambers. It facilitates the inter-hospital inspection appointment, bed appointment and inter-hospital transfer of patients, with strong scalability. This platform and technology application which has realized the system connectivity is reasonable. The hospitals of the same patient can share the medical information, improve the utilization rate of health resources and the patient’s clinic experience. It can further improve the utilization rate of hospital beds and efficiency of clinical work. The unification data for fine management advancement will also provide more data to support.
Numerical Simulation of Q345 Steel Pipe Joint Weld
Authors: Wu Guoqiang
Published: February 2019

Q345 steel pipe is a commonly used welding material. Whether it is shipbuilding, boiler pressure vessel or construction engineering, the demand for Q345 steel is very large. In this paper, the numerical simulation of Q345 steel pipe is carried out. It is analyzed whether the temperature field and stress field of the welded joint are similar to the reality under the condition of two-layer weld seam, so as to prove that the welding process can be implemented accordingly.
Experimental Study on Wettability of Xinjiang Oilfield Crude Oil on Two Kinds of Non-Metallic Pipes
Authors: Wu Yan , Li Yu , Gu Xinjun , Wen Ziyan , Deng Zhian , Yi Kai
Published: February 2019

In recent years, non-metallic pipes have been widely used in oilfield development due to their excellent corrosion resistance. In this paper, the wettability of flexible composite pipe and plastic alloy pipe surface was studied for some crude oil in Xinjiang oilfield. The wettability of the surface of the flexible composite pipe and the surface of the plastic alloy pipe and its influence on the flow resistance were discussed, and the wettability of the crude oil on the metal surface was compared. This experimental study has certain guiding significance for the judgment of pressure drop of crude oil conveyed by flexible composite pipe and plastic alloy pipe.
Comportement mécanique et propriétés thermique des composites polyéthyènes renforcés par des fibres lignocellolusiques
Authors: Ihamouchen Chadia , Djidjelli Hocine , Boukerrou Amar , Fenouillot Françoise , Barres Clair
Published: February 2019

Un intéret particulier a été porté au grignons dʼolive, qui est un sous produit des rejets des différentes huileries. Chaque année, des milliers de tonnes de ce produit sont incinérés ou carrément rejetés dans la nature. Ce dernier, dont les caractéristiques restent à valoriser, est mis à profit par son incorporation comme charge dans lʼélaboration des matériaux composites à matrice polyéthylène haute densité (PEHD). Pour réduire le caractère hydrophile de la farine, un agent compatibilisant (polyéthylène greffé anhydride maléique) commercialisé sous le nom XA255 a été utilisé. Les échantillons obtenus par extrusion et injection seront ensuite caractérisés par différentes techniques dʼanalyse à savoir, le test de traction, lʼanalyse thermogravimétrique (ATG/DTG), lʼanalyse enthalpique différentielle (DSC) et lʼanalyse microscopique électronique à balayage (MEB). Avec lʼincorporation de la farine de grignon dʼolive (FGO) dans la matrice PEHD, la contrainte à la rupture diminue, tandis que la rigidité du matériau et le taux de cristallinité augmentent. Après traitement, on enregistre une amélioration, à la fois de la contrainte à la rupture et du module de Young, due principalement à une meilleure adhésion fibre/matrice, confirmée par lʼanalyse MEB. Lʼanalyse thermogravimétrique a montré une meilleure stabilité thermique des formulations F30 traitée, qui se manifeste par la diminution de la vitesse maximale de décomposition.
Functionally orientated/systemic approach to orthodontic treatment of severe class II division 1 malocclusions: an adapted device, the FABP
Authors: Raymond J.-L.
Published: February 2019

The orthodontic treatment of severe class II division 1 malocclusions is often difficult, which leads some specialists to offer a surgical correction of the overjet. Treatment is made complex by the value of the horizontal overlap as much as the « depth » of deep bite that is very often present alongside the malocclusion. This is why we are offering a treatment protocol including a FABP (Fixed Anterior Bite Plate) which will allow, if the patient cooperates, to correct the anatomic anomaly while concurrently establishing new masticatory cycles in order to stabilize and preserve the results obtained. It is this systemic approach of treatment that is the focus of this article.
Magnesium – der mitochondriale Blockbuster im Leistungssport
Authors: Kisters Klaus , Adamietz Irenäus , Gröber Uwe
Published: February 2019

Magnesium hat beim Leistungssportler zentrale Bedeutung für den störungsfreien Ablauf zahlreicher Stoffwechselprozesse. Der Mineralstoff ist u. a. am Energiestoffwechsel jeder Zelle beteiligt, er beeinflusst die Glukoseverwertung, ökonomisiert die muskuläre und kardiale Bioenergetik der Athleten und verringert bei Ausdauerleistungen das Risiko für Muskelkrämpfe. Bei sportlicher Aktivität steigt der Magnesiumbedarf durch den beschleunigten Glukose- und Energiestoffwechsel, erhöhte Stoffwechselaktivität infolge von Wachstums- und Reparaturprozessen als Anpassungsreaktion des Körpers auf die erhöhte Beanspruchung sowie durch Verluste über den Schweiß. In verschiedenen Studien wurde die signifikante Verbesserung physiologischer Leistungsparameter unter Magnesiumsupplementierung beobachtet.
Cardiometabolic Response to a Single High-intensity Interval Exercise Session Versus Breaking up Sedentary Time with Fragmented High-intensity Interval Exercise
Authors: Bailey Daniel , Orton Charlie , Maylor Benjamin , Zakrzewski-Fruer Julia
Published: February 2019

This study compared the effects of interrupting prolonged sedentary time with high-intensity physical activity (SED-ACT), a volume- and duration-matched high-intensity interval exercise session followed by prolonged sedentary time (HIIE), and prolonged uninterrupted sedentary time (SED) on postprandial glucose, insulin and triglyceride concentrations. Twelve sedentary and inactive but otherwise healthy adults completed 3, 6.5 h conditions in an incomplete counterbalanced order. During SED, participants sat continuously. For HIIE, participants completed 10×60 s cycling bouts at 90% maximum oxygen update (V̇O2max) with 1 min active recovery between bouts. In SED-ACT, 60 s cycling bouts at 90% V̇O2max were completed every 30 min (10 times in total) with 30 s of active recovery immediately before and after. Standardised meals were consumed at 0 h and 3 h and capillary blood samples were collected fasted and every 30 min. Compared with SED, postprandial glucose incremental area under the curve (iAUC) was significantly lower in SED-ACT by 1.91 mmol/L∙6.5 h (p=0.022) and triglyceride iAUC was significantly lower in HIIE by 1.02 mmol/L∙6.5 h (p=0.030). Interrupting sedentary time with high-intensity physical activity can lower postprandial glucose concentrations, whereas a HIIE session can lower postprandial triglyceride concentrations.
Intraoperative Monitoring of the Cochlear Nerve during Neurofibromatosis Type-2 Vestibular Schwannoma Surgery and Description of a “Test Intracochlear Electrode”
Authors: Kasbekar Anand , Tam Yu Chuen , Carlyon Robert , Deeks John , Donnelly Neil , Tysome James , Mannion Richard , Axon Patrick
Published: February 2019

Objectives A decision on whether to insert a cochlear implant can be made in neurofibromatosis 2 (NF2) if there is objective evidence of cochlear nerve (CN) function post vestibular schwannoma (VS) excision. We aimed to develop intraoperative CN monitoring to help in this decision.

Design We describe the intraoperative monitoring of a patient with NF2 and our stimulating and recording set up. A novel test electrode is used to stimulate the CN electrically.

Setting This study was set at a tertiary referral center for skull base pathology.

Main outcome measure Preserved auditory brainstem responses leading to cochlear implantation.

Results Electrical auditory brainstem response (EABR) waveforms will be displayed from different stages of the operation. A cochlear implant was inserted at the same sitting based on the EABR.

Conclusion Electrically evoked CN monitoring can provide objective evidence of CN function after VS excision and aid in the decision-making process of hearing rehabilitation in patients who will be rendered deaf.
Systemic Therapy for Neuroendocrine Neoplasms
Authors: Chan David , Singh Simron
Published: February 2019

Neuroendocrine neoplasms (NENs) are heterogeneous malignancies which are becoming more common. Systemic treatment is considered for patients with advanced disease, and treatment decisions are often driven by the histological grade of the tumor and the site of primary. Somatostatin analogues are the first-line option of choice for gastroenteropancreatic NENs but subsequent options may include the targeted agents everolimus and sunitinib as well as peptide receptor radionuclide therapy. Telotristat is a new option for the treatment of refractory carcinoid syndrome diarrhea. Chemotherapy is infrequently used for Grade 1 to 2 NENs (except for the combination of capecitabine and temozolomide) but is the mainstay of therapy for Grade 3 neuroendocrine carcinomas. Bronchial NENs are graded differently and there are few proven options for systemic treatment. Optimal integration of available systemic therapies, the timely recognition of tumor heterogeneity, and the use of nuclear medicine are areas of ongoing research. Finally, the patient experience is impacted by factors such as delayed diagnosis and symptoms of carcinoid syndrome. Clinicians need to account for patient priorities and disease characteristics to individualize therapy choices for patients with advanced NEN.
The Prevalence of Metabolic Syndrome in the Different Phenotypes of Polycystic Ovarian Syndrome
Authors: Tavares Aleide , Rêgo Barros Romualda Castro
Published: February 2019

Objective To evaluate the prevalence of metabolic syndrome (MetS) in the phenotypes of polycystic ovarian syndrome (PCOS).

Methods This was a cross-sectional study involving 111 women aged between 18 and 39 years old diagnosed with PCOS, according to the Rotterdam Criteria, and grouped into four phenotypes: A: ovulatory dysfunction + hyperandrogenism + polycystic ovaries; B: ovulatory dysfunction + hyperandrogenism; C: hyperandrogenism + polycystic ovaries; D: ovulatory dysfunction + polycystic ovaries. To evaluate the presence of MetS, we measured serum triglyceride levels, HDL cholesterol, fasting blood glucose, blood pressure, and waist circumference.

Results The prevalence of MetS found in this sample was 33.6%, and there was no statistically significant difference (p < 0.05) among the 4 phenotypes. However, phenotype D presented a significantly higher mean glucose level after fasting (93.6 mg/dL) and 2 hours after ingesting a solution with 75 g of anhydrous glucose (120 mg/dL), as well as the lowest mean level of high-density lipoprotein (HDL) cholesterol (44.7 mg/dL). The women in this group demonstrated a high prevalence of abdominal circumference ≥ 80 cm (68.2%), as well as the highest mean abdominal circumference (90.1 cm). Amongst the women with an abdominal circumference ≥ 80 cm, phenotype A increased approximately six-fold the chance of developing metabolic syndrome in relation to phenotype C.

Conclusion The four phenotypes of PCOS demonstrated similar prevalence rates of metabolic syndrome; abdominal obesity presented a relevant role in the development of metabolic alterations, regardless of the phenotype.