bluuebunny/crossref_metadata_2025 huggingface dataset:
An Implementation of Islamic Education Moderation in Indonesia (A Study at Raden Intan State Islamic University of Lampung)
Authors: Asrori Achmad , Sunarto Sunarto
Published: February 2025

Globalization poses significant challenges to Islamic education in Indonesia, particularly regarding character education and scientific integration. This study aims to investigate the implementation of moderation in Islamic education at UIN Raden Intan Lampung in response to contemporary challenges. This study takes a qualitative approach with a phenomenological design. Data was gathered through interviews, observations, and documentation. The data came from Islamic Education lecturers at UIN Raden Intan Lampung. This study looks at curriculum transformation that combines Islamic and modern science, digital learning, and the internalization of religious moderation values. The study's findings show that the moderation of Islamic education at UIN Raden Intan Lampung focuses not only on intellectual development but also on developing the character of students who are moderate, open, and adaptable to social dynamics. Moderate Islamic education is expected to produce competent and globally competitive graduates while preserving Islamic values based on the principle of moderation.
Integration of Communitarianism into Social Philosophy and Public Practice
Authors:   Vologda State University, Bakurkov Anatoly A.
Published: February 2025

The article examines the possibilities of expanding the body of communitarian ideas, including through their enrichment with Russian socio-philosophical thought. Communitarianism is mostly known only as the North American concept of counter-criticism of liberalism, which emerged as a result of the controversy surrounding D. Rawl’s book “The Theory of Justice”. The discourse associated with communitarianism aimed to restore democracy of universal values in the United States, which was threatened by an orientation towards excessive personal individualism. Russian studies of communitarianism are largely limited by the scope of this particular issue, but the “transplantation” of these concepts into the soil of the Russian cultural tradition has significant potential. The author suggests two areas of work: further study of communitarian discourse (including indirectly related concepts) in a socio-philosophical and historical-philosophical way, as well as philosophical explication, theoretical development of the concept of communitarianism as a whole.
Personality Development in the Communicative Environment of Modern Culture
Authors:   n Presidential Academy of National Economy and Public Administration (RANEPA), Shadieva Olga P.
Published: February 2025

The article reveals the specificity of the phenomenology of communication, allowing it to be viewed as a meaningful aspect of social interaction, immersed in the structure of language, myth, and symbol in the sociocultural space of everyday life. In this context, individuals realize themselves as personalities and, based on the socially and personally appropriated experiences acquired through various channels of communication, identify themselves within culture and society. The object of this study is the process of personality formation. The subject is communication as a basic mechanism for filling culture with an infinite variety of meanings and a diversity of social practices, facilitating informational interaction and the exchange of messages that shape opinions, ideologies, traditions, and religions. The aim of this article is to conceptualize the essence of communication in the process of personality formation in the realities of digital modernity. The methodological basis of the research employs the tools of the informational-semiotic approach to obtain a holistic understanding of the role of the communicative system in human life and its cultural development. A comparative-historical and historical-retrospective analysis of materials from scientific and public discourse on communication within the semiotic space is conducted.
Artificial Intelligence as a Tool for Optimizing Managerial Decision-Making Processes in the Russian Federation’s Public Service
Authors:   Central Russian Institute of Management, a branch of the Russian Academy of National Economy  and Public Administration, Poyarkov Rostislav A.
Published: February 2025

This article investigates the issue of implementing artificial intelligence (AI) technologies in the public service system of the Russian Federation as a tool for optimizing managerial decision-making processes. Analysis of existing approaches to defining the essence of artificial intelligence is presented, alongside the author’s conceptual interpretation of this notion. The interrelation between the federal projects “Digital State Administration” and “Artificial Intelligence” within the framework of the national program “Digital Economy” is examined. Key directions and mechanisms for the integration of artificial intelligence technologies into public administration are identified, including the establishment of a specialized predictive analytics platform. The article also analyzes Germany’s experience in utilizing artificial intelligence in the financial sector of public administration, providing recommendations for its adaptation to the Russian context. Specific steps for creating a comprehensive system for the use of artificial intelligence in the public service of the Russian Federation are outlined, taking into account the requirements for information security and the protection of personal data.
Association between Platelet-Lymphocyte Ratio and Troponin-I in NSTE-ACS Patient
Authors: Riyanti Rini , Sutejo Ika Rahmawati , Arif Dina Rizky Amalia
Published: February 2025

Non-ST segment elevation acute coronary syndrome (NSTE-ACS) accounts for 2/3 of cases of acute coronary syndrome in the hospitals in United States. Acute coronary syndrome causes myocardial ischemia, which results in the release of cellular elements like cardiac troponin into interstitial and intravascular spaces. Troponin-I is a marker of heart muscle damage with high sensitivity and specificity. Researchers were interested in analyzing the relationship between Troponin-I and the inflammatory biomarkers Platelet-Lymphocyte Ratio (PLR). Complete blood count is a routine test, which provides information about red and white cells as well as platelets and lymphocytes. This study aimed to determine the correlation between PLR and Troponin-I in a patient presenting NSTE-ACS using cross-sectional design and medical records data of patients presenting NSTE-ACS at Slamet Martodirdjo Hospital, Pamekasan from January to December 2022. The correlation between variables was analyzed using Spearman correlation tests. The Spearman test results showed a p-value of 0.132, indicating a very weak positive correlation between PLR and Troponin-I in NSTE-ACS patients at Slamet Martodirdjo Hospital (r= 0.150, very weak correlation). Receiver Operating Characteristic (ROC) curve analysis of PLR to determine infarct (NSTEMI) in NSTE-ACS patients showed a cut-off of 139.5 for PLR with a sensitivity of 57.9% and a specificity of 59.3%.
Diagnosing Urinary Tract Infection: Bacterial Count and Gram Identification Using Flow Cytometry
Authors: Hayati Mardiyah , Darmawati Sri , Santosa Budi , Lestari Anak Agung Wiradewi , Limijadi Edward Kurnia Setiawan , Felim Jethro
Published: February 2025

Urine culture is still the gold standard for Urinary Tract Infection (UTI) diagnostics, but it takes a long time and expensive. The flow cytometry is a more practical, fast, and reliable test for diagnosing UTI. The study was conducted to determine the validity of the bacterial count with UF 5000 flow cytometry compared to urine culture and to evaluate the coherence between Gram identification (BACT-INFO) results and the manual Gram stain.  This was a cross-sectional study aimed to determine the sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV) of bacterial count compared to urine culture and to evaluate the coherence between BACT-INFO results with manual Gram stain. Urine from 60 patients diagnosed with suspected UTI was assessed for the ability to diagnose UTI using bacterial count from UF 5000 flow cytometry compared to urine culture and to determine the correlation between BACT-INFO with manual Gram staining results. This study was conducted from January to April 2022. Statistical analysis using the ROC curve showed that the Area Under the Curve (AUC) of the urine bacterial count was 0.856 and by setting a cut-off of 961.8/µL, the sensitivity was 84.0%, specificity 88.9%, PPV 97.7%, NPV 50.0%. The concordance of BACT-INFO compared to manual Gram staining is moderate (obtained from Cohen's Kappa coefficient value 0.3269) with a p-value of 0.0000. The most common bacterial species include Escherichia coli (40.67%), Klebsiella pneumoniae ss pneumoniae (20.33%), Proteus mirabilis (10.17%), Pseudomonas aeruginosa (8.47%), and Acinetobacter baumannii (6.78%). Urine bacterial count based on the flow cytometry method with a cut-off of 961.8/µL has sensitivity and specificity > 80% in diagnosing UTI. There is moderate concordance between BACT-INFO and manual Gram staining. The most common bacteria as the cause of UTI include Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Acinetobacter baumannii.
Analysis of Hemostasis Function in Obesity Subjects Using Thromboelastography
Authors: Kasimat Maria Magdalena , Nurahmi Nurahmi , Kurniawan Liong Boy
Published: February 2025

Hemostasis disorders can be caused by obesity, associated with decreased fibrinolysis, increased fibrinogen and plasminogen activator inhibitor activity. Thromboelastography shows hemostasis function from clots formation to the fibrinolysis process. This study aimed to determine the hemostasis function in obese compared to non-obese subjects using thromboelastography. A cross-sectional study at the Clinical Pathology Laboratory Installation of Dr. Wahidin Sudirohusodo Hospital. The study population was non-diabetic subjects who agreed to participate. Hemostasis tests using thromboelastography and analysis of R, K, Alpha angle, and Maximum Amplitude (MA) values were performed. The total number of research subjects was 40 subjects, consisting of 20 obese subjects and 20 non-obese subjects. In these two groups, there were no differences in the K (2.92±1.3 vs. 2.64±1.1, p=0.461), Alpha angle (54.18±9.2 vs. 56.29±10.5, p=0.372), and MA values (57.99±10.3 vs. 54.93±8.2, p=0.766). The obese group got a higher R-value than the non-obese group (7.45±1.8 vs. 4.11±1.2. p=0.006) The R-value was higher (elongated) in the obese subject than the non-obese subject. In the two subject groups, there were no differences in the K, Alpha angel, and MA values.
Insertion site of congenital extrahepatic portosystemic shunts influences clinicopathological findings in dogs
Authors: Demeulemeester Yinthe , de Rooster Hilde , Serrano Gonçalo , Stock Emmelie , Devriendt Nausikaa
Published: February 2025

OBJECTIVE

Determine the influence of insertion site of extrahepatic portosystemic shunts (EHPSS) on clinicopathological findings in dogs.

METHODS

A retrospective study was performed in dogs diagnosed with an EHPSS. Cases were eligible if EHPSS morphology was categorized as portoazygos (PA) shunts, portocaval (PC) shunts entering the prehepatic caudal vena cava at the level of the omental foramen, or portophrenic (PP) shunts. Furthermore, completed standardized questionnaires on clinical signs at diagnosis had to be available. Signalment, clinical scores, and findings on blood analyses and medical imaging were determined and statistically analyzed.

RESULTS

Data of 104 dogs (15 PA, 70 PC, and 19 PP shunts) were included. Dogs with PC shunts were significantly younger than dogs with PA and PP shunts. Furthermore, dogs with PC shunts had a significantly lower body condition score and a significantly worse clinical score compared to dogs with PP shunts. Microcytosis and monocytosis were more pronounced in dogs with PC shunts compared to those with PP shunts. Finally, urea and creatinine concentrations were significantly lower and preprandial serum bile acids and fasted ammonia concentrations were significantly higher in dogs with PC shunts than in those with PP shunts.

CONCLUSIONS

Dogs with PC shunts are more likely to be presented at an earlier age, with more severe clinical signs and more distinct abnormalities in blood parameters compared to dogs with PP shunts.

CLINICAL RELEVANCE

In older dogs with less distinct clinical signs suspected of having an EHPSS, screening for a PP shunt, which is more difficult to diagnose with ultrasonography, is recommended.
Semantic Model Construction as a Way of Learning Polysemous Words Meanings by Students in Linguistics
Authors:   Saint-Petersburg State Chemical and Pharmaceutical University, Zimareva O.
Published: February 2025

The purpose of this article is to describe a method for acquir­ing the meanings of polysemous words through semantic con­struction. This method allows you to associate the meanings of a word in the mental lexicon by identifying the basic components that underlie the meanings. The assimilation of the meanings of a word occurs through a deep processing of meanings, when the meanings are linked into a single system not only through discussion, but through the construction of a semantic diagram of the word. As a result, student can reproduce the meaning of a word in a day and in a week, and also learn to see the connections between meanings in the future. This promotes the de­velopment of metaphorical and critical thinking and the ability to make linguistic guesses. An important element of this approach is the need for students to construct the semantic struc­ture themselves, rather than receive ready-made schemes. This will allow them not only to think independently, but also to bring the unconscious way of decoding meanings to the level of awareness.
The Materialistic Concept of Nature and the “Political-Ecological Glimpses” of Marx in Capital
Authors: Jiménez Vicente Sánchez
Published: February 2025

Objective: The objective of this research is to deepen the materialist vision of nature proposed by Marxist theoretical analysis, with the aim of incorporating a conceptual contribution to study the relationship between ecology and economy.
 
Theoretical Framework: The starting point of this text is the perception of life in a global, environmental and human system that constantly interacts under the concept of coevolution. In this way, the human subsystem is subject to the conditions of the biosphere, in such a way that if the human subsystem breaks these conditions, it will lead us to a situation characterized by an irreversible and global environmental crisis, which provides a solid basis for understanding the context of the research.
 
Method: The methodology adopted for this research includes conceptual keys to approach the study of ecology from a materialist conception of nature through the analysis of Marx's work. Data collection was carried out through the systematic review of Capital.
 
Results and Discussion: The results obtained reveal that the alleged productivist meaning of his work cannot be affirmed in Marx's political writings either. Marx's political work is contradictory in this regard; Sometimes communism appears as the human scenario of continuous abundance (more typical of the part of his work closest to political agitation), a rhetoric in which we must consider the subject who receives it, the working class of the 19th century, who suffers living and working conditions that can be described as inhuman. However, in other parts of Marx's political work, the author entrusts the future society with the mission of filling the metabolic gap caused by the capitalist mode of production, restoring humanity's interaction with nature in ways that we would today describe as ecological.
 
Research Implications: The results can be applied or influenced in the field of study of Political Economy. These implications could also cover such prominent areas as sustainable development and the circular economy.
 
Originality/Value: This study contributes to the literature by highlighting that the crisis of sustainability and the debate on the physical limits of growth find a material explanation in Marx through the analysis of the functioning of the capitalist mode of production. The relevance of this research is evident in that it is the objective logic of the economic system itself that is at the base of the metabolic gap that currently exists between humanity and nature, being especially valuable for the reinforcement of theoretical and practical approaches referred to raising the need for a new productive and accumulation model.
Barriers to E-Commerce Adoption for MSMEs in LAZISMU East Java
Authors: Mochamad Mochklas  , Dwi Songgo Panggayudi  , Anggita Nurhayati
Published: February 2025

The growth of e-commerce has become a rapidly growing sector in recent years, but micro, small and medium enterprises (MSMEs) are still lagging in utilising e-commerce. This study aims to analyse the influence of decision-making barriers, technological barriers, organisational barriers, environmental barriers and consumer trust barriers in e-commerce on the business performance of MSMEs fostered by LAZISMU East Java. 226 MSMEs fostered by LAZISMU East Java participated as respondents in this study, and the incoming data was processed using SmartPLS 3.0. The data analysis determined that technological and environmental barriers significantly positively affected the business performance of MSMEs fostered by LAZISMU East Java. Meanwhile, decision-making, organisational, and consumer trust barriers had a positive but insignificant effect on the business performance of MSMEs fostered by LAZISMU East Java.
Espacio público en la ciudad mexicana del siglo XXI
Authors: Hernández Bonilla Mauricio , Quintal Cano Eduardo , García García Eunice del Carmen , Ortiz Valoy Juan Pablo , Rojo Carrascal Juan Carlo , Torres Pérez Maria Elena , Rodríguez Vera María Bernardet , Sánchez Mejorada Fernández Landero María Cristina , Hernández García Jaime , Perdomo Guzmán José Gabriel , Kuri Camacho José Francisco Javier , García Rodríguez Ismael , Gutiérrez Fernando , Rodríguez Rodríguez Alejandra
Published: February 2025

Este libro es producto de profesionales, docentes e investigadores de la arquitectura y del urbanismo interesados en los temas de producción, conformación y consumo del espacio urbano público en las ciudades para la configuración y la estructuración física del desplazamiento de personas y de productos, así como de la interacción, la convivencia social, la comunicación de ideas y el ejercicio de ciudadanía.

Se exponen aquí algunas reflexiones sobre experiencias de los procesos que intervienen en la ordenación de lo público; otras profundizan en las interacciones sociales, los diversos usos y las apropiaciones que de él hacen los habitantes y que le dan sentido, carácter e identidad a dichos espacios. También se incluyen cavilaciones acerca de las dinámicas que dan luz a cómo pensamos e imaginamos las ciudades.
PENGARUH KEPUTUSAN INVESTASI, KEPUTUSAN PENDANAAN, DAN KEBIJAKAN DIVIDEN, TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI SUB SEKTOR OTOMOTIF DAN KOMPONEN YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2017-2020 Era sebelum Pandemi Covid 19
Authors: Widjanarko Widjanarko Widjanarko , Irawaty Henny
Published: February 2025

Penelitian ini bertujuan untuk mengetahui Pengaruh Keputusan Investasi, Keputusan Pendanaan dan Kebijakan Dividen terhadap Nilai Perusahaan. Populasi dalam penelitian ini adalah Perusahaan Sektor Industri Sub Sektor Otomotif dan Komponen Yang Terdaftar di Bursa Efek Indonesia Periode 2017-2020. Metode penentuan sampel dilakukan dengan metode purposive sampling. Data yang diperoleh sebanyak 9 perusahaan dengan kurun waktu 4 tahun yang dihubungkan dengan 4 variabel penelitian, yaitu 3 variabel independen yaitu keputusan investasi, keputusan pendanaan dan kebijakan dividen dengan 1 variabel dependen yaitu nilai perusahaan. Metode analisis yang digunakan dalam penelitian adalah uji asumsi klasik yang terdiri dari uji normalitas, uji multikolinearitas, uji heteroskedastisitas dan uji autokorelasi. Untuk uji hipotesisnya menggunakan uji parsial (uji t), uji simultan (uji F) dan uji koefisien determinasi. Hasil penelitian ini menunjukan bahwa (1) variabel keputusan investasi berpengaruh negatif dan tidak signifikan terhadap nilai perusahaan, (2) variabel keputusan pendanaan berpengaruh negatif dan signifikan terhadap nilai perusahaan, (3) variable kebijakan dividen berpengaruh positif dan tidak signifikan terhadap nilai perusahaan, (4) secara simultan keputusan investasi, keputusan pendanaan dan kebijakan dividen berpengaruh positif dan signifikan terhadap nilai perusahaan.
Offence at a Butcher Shop: Halal Pragmatics, Authoritarian Politics, and Neoliberal Economy in Mumbai
Authors: Tayob Shaheed
Published: February 2025

‘We are Muslim, we slaughter halal,’ Hassan muttered in irritation in response to a customer’s request to observe the recitation of the tasmiya upon slaughter. His assertion of Muslim identity as a source of trust in halal performance articulates a practice of halal that is now under threat from new forms of halal piety and the documentary demands of halal certification that each foreground complexity, suspicion, and doubt as the basis for halal in the contemporary world. In India where Hindu Nationalist discourse situates the imaginary of the Muslim-as-butcher as the symbolic antithesis of the nation, and where neoliberal aspirations forge a shiny future without Muslim presence—the stakes of offence, suspicion and purity are urgent. I foreground Islamic legal debates on halal as alternating between contested definitions of halal and pragmatic consideration of how trust in halal quality is to be established. Everyday halal practice in Mumbai is legible at the intersection of historically formulated forms of reason, intention, affect and material practice within a changing global market economy and an increasingly hostile political context. Moments of affective breakdown between Muslim customers and butchers reveal the intimacy between new forms of halal piety, a Hindutva politics of abjection, and the exclusionary economy of neoliberal aspiration. Through halal pragmatics, I argue for an ethical anthropology whereby contestations over forms of relation, materiality and subjectivity may form the basis for an ethical critique of political, economic, and scholarly formations.
Surgical outcomes of «inferior» recurrent retinal detachment complicated by advanced stages of anterior proliferative vitreoretinopathy using intraoperative and short-term postoperative perfluorocarbon liquid endotamponade
Authors:   Kirov Military Medical Academy, St. Petersburg, Russian Federation, Kulikov A.N. , Shevalova T.N. ,   Kirov Military Medical Academy, St. Petersburg, Russian Federation, Churashov S.V. ,   Kirov Military Medical Academy, St. Petersburg, Russian Federation
Published: February 2025

Purpose. To evaluate results of surgical treatment of «inferior» recurrent rhegmatogenous retinal detachment (RRD), complicated by advanced stage of proliferative vitreoretinopathy (PVR) in «light» silicone oil-filled eyes (SO), depending on the option of using perfluorocarbon liquid (PFCL): vitreoretinal surgery in combination with retinotomy (RT) and intraoperative PFCL endotamponade (vitreoretinal surgery+RT+intraoperative PFCL) and vitreoretinal surgery in combination with RT and short-term postoperative PFCL endotamponade (vitreoretinal surgery+RT+postoperative PFCL).

Material and methods. Results of surgical treatment of 66 patients with «inferior» recurrent RRD in silicone oil-filled eyes by advanced stage of PVR were analyzed. All patients were divided into 2 groups depending on the tactics of using PFCL: vitreoretinal surgery+RT+intraoperative PFCL+SO (36 eyes) and vitreoretinal surgery+RT+postoperative PFCL+SO (30 eyes).

Results. After surgical treatment, anatomical success was similar in both groups with no statistically significant difference (p=0.5). When comparing bestcorrected visual acuity (BCVA) between the two groups 3 months after surgery, visual acuity was significantly higher in group 2 compared to group 1 — 0.05 versus 0.03 (p=0.016). During the observation period of 6 months after the analyzed operations and after removal of the SO, visual acuity was also significantly higher in group 2 compared to group 1 (p=0.01).

Conclusion. In case of «inferior» recurret RRD complicated by advanced stage of PVR in silicone oil-filled eyes, both vitreoretinal surgery in combination with RT and intraoperative PFCL endotamponade and vitreoretinal surgery in combination with RT and short-term postoperative PFCL endotamponade allow achieving the same anatomical results. Vitreoretinal surgery combined with RT and short-term postoperative PFCL endotamponade may be the best choice to achieve a better functional outcome.

Key words: recurrence of rhegmatogenous retinal detachment, retinotomy, vitreoretinal surgery, silicone oil, perfluorocarbon liquid, advanced stage of proliferative vitreoretinopathy.
Unextendibility, uncompletability, and many-copy indistinguishable ensembles
Authors: Halder Saronath , Streltsov Alexander
Published: February 2025

In this work, we explore the notions unextendible product basis and uncompletability for operators which remain positive under partial transpose. Then, we analyze their connections to the ensembles which are many-copy indistinguishable under local operations and classical communication (LOCC). We show that the orthogonal complement of any bipartite pure entangled state is spanned by product states which form a nonorthogonal unextendible product basis (nUPB) of maximum cardinality. This subspace has one to one correspondence with the maximum dimensional subspace where there is no orthonormal product basis. Due to these, the proof of indistinguishability of a class of ensembles under LOCC in many-copy scenario becomes simpler. Furthermore, it is now clear that there are several many-copy indistinguishable ensembles which are different construction-wise. But if we consider the technique of proving their indistinguishability property under LOCC, then, for many of them it can be done using the general notion of unextendible product basis. Explicit construction of the product states, forming nUPBs is shown. Thereafter, we introduce the notion of positive partial transpose uncompletability to unify different many-copy indistinguishable ensembles. We also report a class of multipartite many-copy indistinguishable ensembles for which local indistinguishability property increases with decreasing number of mixed states.
Integration of secure quantum communication protocols into edge device using quantum-enhanced generative adversarial networks (QE-GANS)
Authors: Radhakrishnan Abilash , Jermisha Railis Dani , R S Dinesh , Fready R Dani Joan , Chandrasekaran Sentihil Kumar
Published: February 2025

Enhancing data security and privacy in distributed computing environments presents a key challenge in effectively deploying quantum protocols on edge devices with limited resources. The objective of this project is to enhance the security of edge devices by integrating secure quantum communication protocols using Quantum-Enhanced Generative Adversarial Networks (QE-GANs). To provide safe quantum communication integration for QE-GANs on edge devices, researchers can gather the necessary data through the data collection process from edge devices. For data pre-processing in speech recognition applications, Mel-frequency Cepstral Coefficients (MFCCs) are a popular choice. Measurement-Device-Independent Quantum Key Distribution (MDI-QKD) is a cutting-edge method that provides advanced security compared to conventional QKD for secure communication among edge devices. SMLA refers to secure multiparty logic and its utilization, a framework that enables secure communication between multiple parties while ensuring the confidentiality and integrity of the transmitted data. Qubit-masked messages (QMM) and Quantum Coded Modulated Discrete Permutation (QC-MDPC) are two sophisticated quantum communication methods for data encryption. ρ represents the quantum state density matrix; DFR refers to Device-Independent Quantum Secure Randomness Generation Protocol. MATLAB will be utilized to simulate and analyse the performance of QE-GANs) for integrating secure quantum communication protocols into edge devices. The findings show that the peak energy value of 23.7568 represents the dominant frequency component, which plays a key role in significantly influencing the signal. Integrating secure quantum communication protocols with edge devices via QE-GANs could revolutionize data privacy, enhancing real-time encryption, robust authentication, and decentralized trust, paving the way for next-gen secure IoT networks.
Two-tier Selectivity in PROTAC-Prodrugs Targeting Prostate Cancer
Authors: Laul Eleen , Gosselé Katherine , Nevado Cristina
Published: February 2025

PROteolysis TArgeting Chimeras (PROTACs) is a highly promising class of therapeutic agents that degrade target proteins through a catalytic, event-driven mechanism. However, their broad activity and lack of tissue selectivity can lead to on-target toxicities off-site in healthy tissues, limiting their clinical potential. To address this, we developed a novel two-tier selective PROTAC prodrug 1, that specifically targets prostate cancer (PCa), based on the well-established BRD4 degrader MZ1. Compound 1 combines a PSMA-617-derived ligand for selective uptake into prostate-specific membrane antigen (PSMA)-positive PCa cells with a glutathione (GSH)-responsive disulfide linker to release the active PROTAC MZ1 inside cancerous cells, which have elevated levels of GSH. The probe efficiently released MZ1 in a GSH-dependent manner ex cellulo, however, remained stable in cell culture media alone. In cellular studies, 1 degraded BRD4 and showed potent antiproliferative activity in PSMA-positive LNCaP cells, while considerably reducing toxicity in healthy tissue-derived MRC5 and HEK293T cells. These results highlight the potential of our PROTAC prodrug strategy for targeted therapy of PCa and provide a foundation for further mechanistic studies using ex and in cellulo models.
STATUS AND ECONOMIC IMPACT OF YARSAGUMBA (OPHIOCORDYCEPS SINENSIS) COLLECTION IN DOLPA DISTRICT OF NEPAL: A DETAIL REVIEW
Authors: Thapa Bharat , Thapa Rajan
Published: February 2025

The high-altitude grasslands of the Tibetan Plateau and the Himalayas are home to the endemic species complex known as Chinese caterpillar fungus, which has a number of distinctive characteristics belonging to the order Hypocreales of the family Ophiocordycipitaceae. Yarsagumba is a valuable, low-volume organic Himalayan medicinal herb that is becoming more and more popular abroad, greatly boosting the local economies of the mountain people. It has been used as a tonic and aphrodisiac to treat a variety of conditions, such as cancer or tumor diseases, respiratory issues, liver or kidney problems, and hyperglycemia. A total of thirty-five published publications were taken out and examined from websites like Research Gate and Google Scholar. The morphology, distribution, status, therapeutic relevance, and economic significance of the species have all been investigated in this study.
A influência da espiritualidade na crise emocional em clientes oncológicos
Authors: Silva Joyce Soares e , Pereira Tatiane Fonseca , Fernandes Márcia Astrês , Rocha Eukalia Pereira da , Avelino Fernanda Valéria Silva Dantas , Oliveira Ana Lívia Castelo Branco de
Published: February 2025

Objetivo: Compreender a espiritualidade como fator de influência na crise emocional de clientes com câncer. Métodos: Estudo de métodos mistos, orientado pela Teoria Fundamentada nos Dados, que fornece explicações para as preocupações dos indivíduos. Estudo realizado em um Hospital de tratamento oncológico. A coleta de dados ocorreu de julho a setembro de 2018, por meio de dois instrumentos: um roteiro de entrevista semiestruturada e a Escala de Avaliação da Espiritualidade em Contextos de Saúde. A análise qualitativa identificou as fases da crise, enquanto a análise quantitativa permitiu associá-las à espiritualidade dos clientes, e a identificar o perfil sociodemográfico dos participantes. Resultados: Participaram 30 clientes, com predomínio de mulheres, câncer de mama, faixa etária acima de 50 anos, ensino fundamental incompleto, casados, com filhos e católicos. Foram elaboradas duas categorias sobre a vivência da crise emocional e sua relação com a espiritualidade: a crise emocional no contexto oncológico e a influência da espiritualidade na crise emocional vivenciada por clientes com câncer. Conclusão: A espiritualidade mostrou ser um fator de proteção durante a crise emocional decorrente do diagnóstico de câncer. Os participantes apresentaram score positivo para uma boa espiritualidade com base na escala aplicada, e boa resolução da crise estabelecida.
Assistência recebida na Atenção Básica: perspectiva de pacientes em cuidados paliativos oncológicos e suas famílias
Authors: Carvalho Juliane Maria Guedes de , Sanguino Gabriel Zanin , Murilho Jordhan Abner Teixeira , Oliveira Lucas Eduardo de , Luz Mateus Souza da , Marcon Sonia Silva , Barreto Mayckel da Silva
Published: February 2025

Objetivo: compreender como ocorre a assistência à saúde no âmbito da Atenção Básica na perspectiva dos pacientes oncológicos em cuidados paliativos e seus familiares. Métodos: estudo descritivo-exploratório, de abordagem qualitativa, realizado com pacientes diagnosticados com câncer em cuidados paliativos e seus familiares. A coleta de dados ocorreu entre setembro e novembro de 2023, a partir de entrevistas abertas, guiadas por instrumento semiestruturado. O áudio gravado foi transcrito na íntegra e, posteriormente, analisado a partir da Análise de Conteúdo. Resultados: foram identificadas duas categorias temáticas: “Cuidados em saúde dispensados pela Atenção Básica” e “Satisfação com o atendimento apesar dos entraves percebidos”. A assistência em saúde envolveu encaminhamentos a especialistas, apoio no diagnóstico inicial e tratamento de consequências físicas da doença. Apesar dos entraves vivenciados, como demora e falta de capacitação profissional, os participantes perceberam a assistência como satisfatória. Conclusão: os cuidados paliativos não estão presentes na rotina da Atenção Básica, o que, em certa medida, pode ser reflexo da necessidade de preparo profissional.
PEREMPUAN BERSANGGUL NUSANTARA: THE PRACTICES OF COMMUNITY EMPOWERMENT BASED ON INDIGENOUS LEARNING FROM A GENDER EQUALITY PERSPECTIVE
Authors: Widyaswari Monica , Fakhrudin Ali , Oktavia Elvira
Published: February 2025

Perempuan Bersanggul Nusantara is a community of women who care about national development programs. One of the activities implemented to date is skills-based empowerment activities. This activity is intended to give women good skills where their potential can be developed. The development of women's potential is a manifestation of women's empowerment so that women are more qualified and can participate in development. The application of indigenous learning in empowerment by the Perempuan Bersanggul Nusantara community has its meaning, namely an application of learning about local culture and customary values that are attempted to increase appreciation for the practice of daily activities. The approach used in this study is qualitative with a case study method. The study subjects were the Perempuan Bersanggul Nusantara community and women (adolescents and adults). Data collection techniques used in-depth interviews, participatory observation, and documentation studies. Data analysis techniques used the Miles and Huberman interactive model. The results of this study are (a) Perempuan Bersanggul Nusantara reviewed in the Socio-Cultural Context; (b) Indigenous Learning in Women's Empowerment in the Perempuan Bersanggul Nusantara Community; (c) Gender Equality Perspective in Perempuan Bersanggul Nusantara.
COMPARATIVE ANALYSIS OF REGRESSION AND COLLABORATIVE FILTERING MODELS FOR RECOMMENDATION SYSTEMS: AN EMPIRICAL STUDY
Authors: Bali Nisha , Singh Kulvinder , Dhawan Sanjeev
Published: February 2025

Recommendation systems are very crucial for enhancing the utility of a given product and or service for a specific user in different fields. This paper focuses on the comparison of various filtering techniques in order to determine their effectiveness in identifying the preferences of the user. The paper also looks into basic methods like user-based collaborative filtering and item-based collaborative filtering, which uses the item's attributes. Also, the paper assesses the subsequent methods such as linear regression, ridge regression, Lasso regression, random forest regression, and XGBoost regression. From the performance evaluation metrics, the researchers reach RMSE and MAE to compare the effectiveness of the proposed methods and reveal their weaknesses. This paper aims to evaluate the performances of the above filtering approaches to gain an understanding of the extent to which these methods improve the recommendations' accuracy and contribute to the literature by providing recommendations on filtering models suitable for various recommendation tasks.
THE INFLUENCE OF MOMENTUM AND CONCENTRATION SLIP BOUNDARY CONDITIONS ON A FERROMAGNETIC DIPOLE WITH RADIATION, THERMOPHORESIS, AND BROWNIAN MOTION
Authors: Vullam Nagagopiraju , Rama Prasad Jupudi Lakshmi , Kumari M. Aruna , Adireddy Ramesh , Rao Y. Subba , Mahalaxmi U. S. B. K. , Kumar R. Anil , Dharmaiah G. , Prabhakar Rao Desamala , Patchala Sarala
Published: February 2025

A magnetic dipole effects nonlinear thermal radiation from ferromagnetic liquid when stretched provinces are analyzed numerically utilizing various parameters pertinent to the problem. Ferrofluid will undergo a phase shift and become magnetic when it is in a magnetic field. This technique is useful in various fields, including electronics, loudspeakers, and materials research. This research aimed to gain further knowledge about the one-of-a-kind continual flow of ferrofluids via permeable medium, including Brownian and thermophoresis influences. Ordinary differential equations may be generated using the appropriate similarity transformation. After that, the equations are solved by using the approach known as bvp4c. Calculations are carried out to obtain the results of physical parameters with non-dimension quantities. The effects of velocity, temperature, and concentration, as well as the applications of these factors, are shown graphically. The velocity is affected in various ways by two factors, namely, the ferromagnetic parameter and the distance. The concentration is increased due to both the thermophoretic and Brownian variables. The frictional force rises as the ferromagnetic and Brownian motion parameters increase, yet the Sherwood and Nusselt numbers decrease throughout this process.
universidades en entornos globales y los estilos de liderazgo docente. Una revisión bibliométrica.
Authors: Izaguirre Olmedo Jorge , Jordán Correa Dennys , López Brunett Ana
Published: February 2025

La sinergia entre universidades e industrias tiene una tendencia creciente dejando en evidencia la importancia de la intervención de las instituciones de educación superior en el mercado. El liderazgo educativo y su incidencia en la motivación y la consecución de resultados de aprendizaje en los estudiantes es imprescindible para el impacto deseado de la academia en la economía. Esta investigación tiene por objeto presentar el impacto de las universidades en un entorno global, así como la importancia del liderazgo educativo. Para el efecto, se ha planteado una investigación cualitativa de tipo revisión bibliométrica. Se han analizado 49 investigaciones, principalmente de SCOPUS y WOS, en inglés y español. Los resultados denotan que las universidades deben reforzar sus esfuerzos en investigación e innovación, así como la transferencia de conocimiento a los mercados. Se identificó que el liderazgo educativo debe adaptarse a las realidades estudiantiles, para que se consigan los objetivos educativos. Los autores concluyen en la necesidad de explorar las habilidades de liderazgo docente y su relación con la motivación en los estudiantes.
LA EXPLORACIÓN Y EXPLOTACIÓN DE ACEITE/GAS SHALE EN TAMAULIPAS ¿UN BENEFICIO ECONÓMICO Y SOCIAL O UN RIESGO AMBIENTAL Y SOCIAL?
Authors: GARCÍA-SALAZAR Edith Miriam
Published: February 2025

Este trabajo analiza la actividad industrial de exploración y explotación de aceite/gas shale en Tamaulipas, desde la perspectiva de economía ecológica, para lo cual se genera una visión integral alternativa que incorpora los ámbitos social, ambiental, económico y político. A través de este punto de vista es posible identificar las posibles repercusiones de dicha actividad extractiva en la población tamaulipeca, que utiliza la técnica de fracturación hidráulica. De esta manera se cuestiona si esta actividad industrial representa un beneficio económico y social, como se enuncia en los discursos políticos de la Reforma Energética, o un riesgo ambiental y social provocado por la técnica utilizada, la cual es catalogada como altamente contaminante.
PRESIÓN SOCIOCULTURAL HACIA LA IMAGEN CORPORAL DE LA MUJER Y CÓMO AFECTA EN EL DESEMPEÑO ACADÉMICO
Authors: SALAZAR-ROCHA Karla Isabel , GUZMÁN ACUÑA Josefina
Published: February 2025

El presente trabajo aborda el tema de la presión sociocultural hacia la imagen corporal de la mujer como uno de los problemas que hoy en día aqueja a mucha de la población femenina. Se hace hincapié en las jóvenes entre 16 y 18 años, ya que ésta es una edad vulnerable a presentar dicho problema. Asimismo, la manera en cómo influye y/o afecta su desempeño académico y conocer la autopercepción que tienen las estudiantes de la Preparatoria Federalizada No. 1 Ing. Marte Gómez en Ciudad Victoria, Tamaulipas, México.
La imagen corporal comienza a formarse poco a poco desde nuestro nacimiento. No es fija, puede cambiar a lo largo de nuestra vida, y tiene una mayor importancia durante la adolescencia. Esta etapa es considerada de gran vulnerabilidad hacia la apariencia física, pues es cuando se desarrollan el sentido de identidad y los roles sexuales, trayendo consigo la insatisfacción corporal.
Asher y Asher (1999) entienden que la imagen corporal describe una relación compleja entre aspectos tales como normas culturales, género, identidad, estima propia, entre otros.
EL DERECHO AL SUFRAGIO DE LA MUJER
Authors: GARZA-GUERRA María Taide
Published: February 2025

En México, en 1953 se reconoció el derecho al sufragio femenino gracias a la organización y participación de las mujeres en los foros públicos demandando derechos ciudadanos, sólo que ese avance no se materializó hasta por lo menos dos décadas después, debido a que en la mayoría de los casos seguían siendo los hombres quienes decidían lo que sus esposas, hijas o hermanas debían hacer.
En las elecciones del 3 de julio de 1955 las mujeres acudieron por primera vez a las urnas a emitir su voto; en esa ocasión se elegía a di- putados federales para la XLIII (Cuadragésima Tercera) Legislatura. Pese a la importancia que tenía ese primer ejercicio democrático de libertad de decisión, la verdadera democratización de la ciudadanía tardó mucho más en generarse, sobre todo porque la tradición imperaba sobre la razón.
Se constituyó el concepto de género como categoría de análisis para explicar los mecanismos de opresión, y a partir de ahí se abrió la posibilidad de equidad, lo que en la práctica sembró la semilla de la democracia, entendida ésta como la igualdad de los géneros, conservando las diferencias biológicas, entre otras.
ESTADO DEL CONOCIMIENTO DE LAS CIENCIAS SOCIALES EN TAMAULIPAS: TEMAS CRÍTICOS Y DESAFÍOS PARA SU CONSOLIDACIÓN ACADÉMICA (1990-2016)
Authors: CONTRERAS-OCEGUEDA Koryna , GÓMEZ-CORDERO Xóchitl , LARA-GUERRERO José Francisco
Published: February 2025

Este trabajo muestra el estado del conocimiento de las ciencias sociales en Tamaulipas durante los años 1990-2016. El estudio se estructuró en tres apartados: I) Surgimiento de la docencia y la investigación; II) Diagnóstico de los investigadores, líneas y productividad académica; y III) Análisis de los temas críticos y desafíos que se enfrentan para su institucionalización y consolidación académica. El trabajo concluye que existen temas viejos y nuevos en la agenda, así como una ruptura en el campo, que gira en dos sentidos: la primera radica en el surgimiento y desarrollo de nuevos asuntos, temas y líneas de investigación y, la segunda, en una mudanza en el abordaje de los viejos temas críticos desde nuevos puntos de partida teóricos y nuevos paradigmas metodológicos.
LAS FUERZAS ARMADAS MEXICANAS COMO INSTRUMENTO DE POLÍTICA EXTERIOR EN EL CONTEXTO DE LA SEGURIDAD NACIONAL
Authors: ALCALÁ-FERRÁEZ Luis Gerardo
Published: February 2025

La seguridad nacional es considerada un concepto normativo central en el diseño y articulación de la política exterior de los Estados, ya que precisamente a través de su política exterior, éstos buscan promover y defender sus intereses y objetivos nacionales en el exterior. Aunque las fuerzas armadas no han perdido su rol tradicional en materia de defensa y protección de la soberanía e integridad territorial, la nueva visión ampliada e incluyente del concepto seguridad nacional les ha asignado nuevas atribuciones. Entre otras, las de estar preparadas en tiempos de paz, para atender los compromisos y responsabilidades del Estado relacionados con el mantenimiento de la paz y la seguridad internacional. El artículo analiza la medida en que el Estado mexicano ha empleado a sus fuerzas armadas como instrumento de política exterior en el contexto de la seguridad nacional.
EL ÍNDICE DE SEGURIDAD NACIONAL DE MÉXICO: UN MODELO DE MEDICIÓN MULTIFACTORIAL
Authors: VERGARA-IBARRA José Luis
Published: February 2025

La seguridad nacional es un tema complejo que debe ser analizado y medido desde una perspectiva multidimensional. El Índice de Seguridad Nacional de México (ISNM) es un instrumento que, por primera vez, permite una medición holística de este concepto, al reducir una gran cantidad de información compleja, a partir de variables dadas, en una expresión más simple de entender, pero sin perder su confiabilidad y manteniendo la capacidad de analizar las causas subyacentes que generan un resultado específico. En consecuencia, esto facilita un análisis detallado y estructurado del tema, lo que puede servir como un mecanismo que ayude a los niveles estratégicos involucrados con la seguridad nacional del país, a establecer los asuntos prioritarios de atención, así como la correspondiente toma de decisiones.
DESIGUALDAD SOCIAL Y EDUCATIVA EN MÉXICO Y ESPAÑA: NUEVAS FORMAS DE ATENDER EL DESARROLLO
Authors: LERA-MEJÍA Jorge Alfredo , MARTÍNEZ-COLL Juan Carlos , OCHOA-GARCÍA RO Fernando , RIVAS-FLORES José Ignacio
Published: February 2025

Para no quedar en deuda con este tema de actualidad intelectual, en el segundo semestre de 2016 iniciamos el abordaje de la importante problemática que tiene la desigualdad educativa dentro de la propia desigualdad económica. Por ello iniciamos trabajos por parte de investigadores de la Unidad Académica Multidisciplinaria de Ciencias, Educación y Humanidades (UAMCEH) de la Universidad Autónoma de Tamaulipas (UAT); el Centro Multidisciplinario de Investigaciones Regionales (CeMIR) de la UAT/UNAM y la Unidad Académica de Ciencias Jurídicas y Sociales (UACJS) de la UAT, en coordinación con grupos de investigación de las Facultades de Dere- cho (FD) y Ciencias de la Educación (FCE) de la Universidad de Málaga (UMA) y, recientemente, con investigadores de la Universidad Lagos del Sur de Chile.
Esperamos lograr, en este esfuerzo académico, dentro de la celebración del I Congreso Internacional online de la serie EumedNet, privilegiar el tema “Desigualdad social y educativa: el problema del acceso a la educación de calidad y democrática”. El presente ensayo forma parte central de este primer congreso, buscando primeramente repasar los diversos autores clásicos y de actualidad en el tema, así como comparar la desigualdad social y educativa entre México y España, dos países con similares condiciones de idioma y cultura, pero con diferencias importantes en desarrollo y equidad.