bluuebunny/crossref_metadata_2025 huggingface dataset:
Problematic Technology Use in University Students: Example of a Foundation University
Authors: Aktan Mehmet Can , Gökçearslan Elif
Published: September 2022

This study, which focuses on the use of problematic technology in university students, focuses on the dimensions of the relationship university students establish with technology, and aims to reach a holistic and deep understanding of the negative and destructive effects and consequences of this relationship. The research designed in quantitative design is based on the relational screening model. Within the scope of the research, it was aimed to look at the technology usage habits of the participants. For this purpose; Personal Information Form, Technology Addiction Scale and Technological Addiction Scale were used. The sample of demographic information obtained from university students at a foundation university consists of 392 participants, 340 (86.7%) female and 52 (13.3%) male students. Participants' technology usage characteristics, time spent with technology, thoughts about the COVID-19 process and addiction levels were revealed within the scope of the findings. Considering that deprivation, difficulty in control, impaired functionality and social exclusion are indicators of problematic technology use, it is seen that the time spent on technological components and usage habits are predictors of problematic use. The results have been discussed in the light of the current literature.
Morphological and anatomical parameters of Forsythia suspensa (Thunb.) Vahl leaves in the urban environment
Authors: Leshcheniuk Olena , Koniakin Serhii
Published: September 2022

The anatomical and morphological parameters of the leaf blade of Forsythia suspensa were investigated to determine the species’ stability in the Kyiv metropolis (Ukraine) conditions and monitor environmental pollution. The leaves of F. suspensa were selected at four monitoring sites in Kyiv, which differed in their distance to highways and the intensity of traffic. The histological structure of F. suspensa leaves changed toward xeromorphism in the variants where plants were exposed to increased vehicles’ emissions. In particular, the thickness of the cuticle and adaxial epidermis increased, the stomatal size decreased, the degree of stomata opening decreased and their density increased, and the stomatal index and xeromorphism index increased. In general, such changes in the structure of F. suspensa leaves increased the plants’ resistance to pollution. This indicates the plasticity of F. suspensa plants and a sufficient level of their adaptation to the urban environment. Hence, the parameters of the stomatal apparatus of F. suspensa leaves can be applied as test indicators for biomonitoring of urban pollution. This species can be recommended for creating stable culturphytocoenoses in conditions of a high level of technogenic influence.
Piper Betel Leaf Phytochemical Study and Antimicrobial Effect against Clinical Bacterial Isolates
Authors: Das Reshma , Pandey Priyanka , Chandravanshi Mahendra , Raja Wasim
Published: September 2022

Herbal resources are useful for traditional medicine, folk medicine, modern medicine, nutraceuticals, dietary supplements, pharmaceutical intermediates, and chemical precursors for synthetic drugs. The antibacterial qualities of the leaves of piper betel, also known as paan, have long been employed in Indian traditional medicine. A methanol extract of Piper betel leaves was examined for its ability to inhibit the growth of Bacillus subtilis, Bacillus cereus, Bacillus frimicutes, Escherichia coli, Entrobacter, Klebsiella, and other bacteria (both gram-positive and gram-negative bacteria).The extract of Piper betel leaves also contained proteins, glycosides, alkaloids, flavonoids, terpenoids, tannins, fixed oil, and lipids. The antibacterial activity was evaluated using the agar disc diffusion method. The outcomes shown that the antibacterial properties of Piper betel Linn's limit the growth of microorganisms in a dose-dependent manner. The outcomes demonstrate that the extract from Piper betel possesses antibacterial activity in the tested system. Secondary metabolites are thought to be produced by this plant. The results also imply that favorable results can emerge from habitually using herbs with historical efficacy claims in scientific study.
Application of NLP and ML Using a Refined Dataset
Authors: Meena Munesh , Sehrawat Ruchi
Published: September 2022

Machine Learning (ML) is a technology that can revolutionize the world. It is a technology based on AI (Artificial Intelligence) and can predict the outcomes using the previous algorithms without programming it. For our project, we will take the help of NLP (Natural Language Processing) which will help us to perceive and sort fake/spam comments. Also, we will be using this tool to prevent fake promotion and help people when buying products on E-commerce sites and as well as to avoid fake comments on Social Media Platforms that spread hate among people. This application will create a transparent and safe internet for everyone. Spam-Attack will be using NLP to achieve the goal and create a better ecosystem for browsing the internet.
CLOSED LOOP BIDIRECTIONAL BUCK-BOOST CONVERTER FOR BATTERY
Authors: MITHULKIRUTHIK K S  , KARTHICK K  , KIRITHARAN C  , N.RISHIKESH
Published: September 2022

Charging and discharging batteries A DC bus (with a constant voltage), a battery, a common load, and a bidirectional two-switch Buck-Boost DC-DC converter are used here.1- The control of battery charging as well discharging is based on using PI controllers 2- The other is for battery current regulation. The presented case study includes two modes of operation: 1-Charging mode: automatically activated when
the DC bus is connected and the control objective i.e.: set point (of the PI closed loop) becomes the full voltage of the battery. 2-Discharging mode: automatically activated when the DC bus is NOT connected and the control objective (of the PI closed loop) becomes load voltage to maintain the constant load voltage during discharging. In control topology, a distinct control as well as pulse width modulation (PWM) system is created for each mode of operation using the voltage feedback control strategy.
This method of charging and discharging can be used in a vehicle to grid and grid to a vehicle (here vehicle is considered as battery source/ DC source because of the same operation. Renewable energy can be used as a source to reduce pollution. The other mode of charging and discharging can be done with the help of solar as renewable resources to charge the battery. These are the way by which the closed loop buck-boost converter are been used for the battery operation.
An Overview on Ants as Bioindicator
Authors: Keshamma E
Published: September 2022

There is a resurgence to measure or monitor the impact of intensive exploitation of natural resources on environment and original habitats. The indicator qualities of terrestrial invertebrates are widely recognized in the context of detecting ecological change associated with human land-use. However, the use of terrestrial invertebrates as bioindicators remains more a topic of scientific discourse than a part of land-management practice, largely because their inordinate numbers, taxonomic challenges
and general unfamiliarity make invertebrates too intimidating for most land-management agencies. Terrestrial invertebrates will not be widely adopted as bioindicators in land management until simple and efficient protocols have been developed that meet the needs of land managers. There are several characteristics that an indicator species must have, the most notable being ease of measurement,
sensitivity to environmental stress, and predictable responses to environmental stress. Ants are increasingly being recognized as useful tools as bioindicators for land managers to monitor ecosystem health conditions. This group has useful characteristics for successful indication and monitoring of environmental impacts, including widespread distribution, high abundance, importance in ecosystem functioning, ease of sampling, and latively well-known taxonomy and ecology. With this back ground, we aimed to conduct review of literature study with the main purpose to describe and delineate on current perspectives on use of ants as bioindicators.
Survey Study on Traditional Storage Practices of Finger Millet
Authors: Srusti S. N. R  , Prathibha K. Y  , Keshamma E
Published: September 2022

Current study aimed to assess the traditional storage practices being practiced in southern dry zone of Karnataka viz. Mysuru, Mandya, Hassan, Tumkur&Chamarajanagara districts and to identify the best storage practices being followed in these districts. Field survey was undertaken in major finger millet [Eleusine coracana (L.)] growing region of all five districts of Southern Dry Zone of Karnataka viz. Mysuru, Mandya, Hassan, Tumkur & Chamarajanagara. Information was documented by using Participatory Rural Appraisal (PRA) technique like observation and discussion. The data on various methods was collected by contacting the respondents through one-to-one interaction and group discussion methods, the indigenous technologies used by dry land farmers for storage of seed were documented. Survey observations delineated that hagevu, metal bin and gunny bag type of traditional storage practices being followed for the storage of finger millet in southern dry zones of Karnataka viz. Mysuru, Mandya, Hassan, Tumkur & Chamarajanagara districts. Precautionary measures before storage, during storage, and after receipt of grains highlighted in our study were being practiced by farmers in these regions to ensure protection from spoilage of grains. It was demonstrated through our field study that traditional technical skill teaches us how best the utilization of natural sources could be useful for storage and protection of life of grains or seeds.
Modern Application of Internet of Things in Healthcare System: Review
Authors: Hridya Jayakumar  , Malumol S  , Leya Elezabeth Thomas
Published: September 2022

The recent advancement in information and Communication Technology has led to the emergence of the Internet of Things (IoT). In the modern medical system, the use of IoT technology has brought so much convenience to doctors and patients, because IoT is suitable for a variety of medical fields (such as real-time monitoring, patient information management, and health care management). Human body sensor network (BSN) technology is one of the core technologies that is being used in the development of IoT in the medical system. This technology is characterized by a little power supply and lightweight wireless sensor nodes that can be used to monitor patients. The research paper highlights the main requirements of modern medical systems based on BSN.
IoT BASED AUTOMATIC STREET LIGHT CONTROL AND FAULT DETECTION
Authors: Aarthi Mai A S  , Rajeswari N
Published: September 2022

The IoT (Internet of Things) is a booming technology that mainly concentrates on the
interconnection of devices or components to one another and the people. As the time being, many of these connections are changing as Device to Device from Human to Device. Finding the faulty street light automatically is become a vital milestone by using this technology. The primary goal of the paper is to provide control and identification of the damaged street light automatically. Street light fault detector system informs to the concerned area electricity board substation when the street light is not functioning. Because of no proper street light, most of the thefts and accidents are happening.
To avoid that sensors can be included in the light pole which sends the signal to the substation if the light is not functioning properly. Sensor sends the information like Area, Street, and Pole ID Number to the electricity substation. Lineman can easily identify the location from the substation and necessary measures can be taken immediately. Sensors added to identify whether the problem is with the solar light panel/ bulb or any difficulty in electricity distribution system. This approach helps for the lineman to work and fix it.
Construcción de paz ambiental: una revisión narrativa de su conceptualización
Authors: Alvarado Castro Manuel , Sierra-Barón Willian , Oviedo Cordoba Myriam
Published: September 2022

Este artículo presenta una revisión conceptual del término construcción de paz ambiental. Si bien carece de un consenso, se ha avanzado en su definición en las últimas dos décadas debido al interés académico, dada su condición de concepto bisagra entre temáticas relacionadas con el sostenimiento ambiental y la construcción de paz. A partir de una revisión narrativa de literatura se seleccionaron 25 documentos entre artículos científicos, capítulos de libro, tesis de grado y documentos de trabajo obtenidos de diferentes bases de datos. A través del análisis realizado se establecieron 12 núcleos temáticos y 4 categorías emergentes, desde las cuales se ha comprendido y conceptualizado la construcción de paz ambiental (gestión de recursos naturales, cooperación ambiental, dinámicas transformadoras y relaciones pacíficas). Se concluye que la construcción de paz ambiental es un constructo emergente, el cual requiere alcanzar consensos en su orientación con el fin de facilitar la promoción del diseño, implementación, análisis y evaluación de investigación, intervención, políticas y planes de acción que garanticen procesos de paz integrales, estables y duraderos que reconozcan, reparen y no repitan los impactos que sufrió el medioambiente en el marco del conflicto armado, más aún en Colombia que vive una época de posacuerdo.
Role of yoga therapy in the management of diabetic neuropathy: a review article
Authors: Kumar Ramesh , Malik Saloni , Gupta Ananya
Published: September 2022

Background: Autonomic Diabetic Neuropathy, the most frequent diabetic consequence, is commonly treated with medicines without success. Diabetes is a chronic disease due to insulin resistance or reduced insulin secretion, India is known as the "diabetic world capital," with a projected growth of 63 %, exceeding 98 million by 2030. The latest diabetes mellitus statistics are worrying, stating that around 150 million individuals globally have diabetes mellitus, with this number expected to doubling by 2025  
Objective: The purpose of the study was to conduct a review on role of Yoga in the management of Autonomic Diabetic Neuropathy.
Method: A review was conducted using search terms Autonomic Diabetic Neuropathy and Yoga, Autonomic Diabetic Neuropathy and Alternative Therapy, Diabetic Autonomic Neuropathy and Yoga, Diabetic Autonomic Neuropathy and Alternative Therapy, Diabetic Neuropathy and Yoga, Diabetic Neuropathy and    Alternative therapy and all the probable term in national and international data repositories such as PubMed, google scholar, in English language. Only 5 studies are selected out of 1493. For this Review article Literature Searched from starting to till April 2022.
Conclusion: Studies showing clinical significance of Yoga in the management of Diabetic Neuropathy, but studies are less available and also lack of quality study. New Researchers should create more original evidences by conducting Randomized Controlled Trials in the large sample size.
INTERVENSI EDUKASI KESEHATAN PADA PASIEN GAGAL GINJAL KRONIK YANG MENJALANI HEMODIALISIS
Authors: Ariani Sri Purwanti , Firdaus Syamsul , Hiryadi
Published: September 2022

Jumlah Penderita Chronic Kidney Disease semakin tahun semakin meningkat. Terapi yang bisa lakukan oleh penderita CKD adalah dengan Hemodialisis. Peran perawat dalam proses hemodialisis sangat besar karena buruknya dampak komplikasi tersebut, maka intervensi keperawatan harus dilakukan dengan tepat. Studi ini bertujuan untuk mencari berbagai bukti terkait intervensi edukasi kesehatan pada pasien gagal ginjal kronik. Pencarian beberapa literatur berdasarkan pada PRISMA checklist dengan menggunakan 4 database yaitu Scopus, Pubmed, Sciencedirect dan google scholar. Jurnal dipilih sesuai dengan kriteria insklusi menggunakan JBI Critical Appraisal Tools. Sebanyak 15 jurnal dan artikel yang membahas tentang intervensi edukasi kesehatan pada pasien gagal ginjal kronik. Hasil studi dapat disimpulkan bahwa intervensi edukasi offline maupun online memiliki manfaat yang berbeda tergantung tingkat keefektifannya sehingga penerapannya juga tergantung individu yang akan menerima intervensi edukasi tersebut
Pengaruh Clapping, Vibrasi, Suction Terhadap Tidal Volume Pasien Yang Menggunakan Ventilator Di Icu Rsud Kabupaten Tangerang
Authors: Ariyani Dwi , Ria Setia Sari  , Febi Ratna sari
Published: September 2022

Fisioterapi dada merupakan suatu rangkaian tindakan keperawatan yang terdiri dari clapping (perkusi), vibrasi nafas dalam dan batuk yang efektif di gunakan untuk pencegahan atau pengobatan penyakit pernafasan restriktif, kelainan muskuler, penyakit paru obstruktif menahun dan pasien yang menggunakan ventilasi mekanik dalam jangka waktu panjang di karenakan parenkim paru mengalami fibrasi. Fisioterapi dada di gunakan untuk pencegahan dan pengobatan penyakit paru seperti obstruktif menahun, kelaian muscular atau restriktif yang memiliki tujuan membuang sekresi bronchial meningkatkan efisiensi otot – otot pernafasan serta memperbaiki ventilasi. penggunaan ventilator meningkatkan terjadinya HAIs sebanyak 6-21 kali dengan tingkat kematian akibat VAP adalah 24- 70%.Hal ini menyebabkan rata–rata waktu perawatan di icu meningkat menjadi 9,6 hari,serta biaya pengobatan setiap pasien denganVAP bertambah sebanyak US$ 40000. Tujuan penelitian ini adalah mengetahui efektifitas pemberian tindakan clapping, vibrasi dan suction terhadap tidal volume pada pasien yang menggunakan dengan metode quasi eksperimen dengan rancangan populasi dalam penelitian ini adalah pasien ICU RSUD Kabupaten Tangerang yang menggunakan ventilator sebanyak 36 orang pasien periode 1 Juli sampai dengan 7 Agustus 2020, data di peroleh dengan cara melakukan pengukuran volume tidal sebelum dan sesudah di lakukan tindakan clapping,vibrasi dan suction, instumen yang di gunakan adalah lembar observasi pada pasien yang menggunakan ventilator. Uji yang di gunakan dalam penelitian ini adalah T dependent untuk melihat adanya pengaruh clapping,vibrasi dan suction terhadap tidal volume dengan signifikan ( p < 0,05 ). Saran penelitian ini adalah di harapkan kepada pihak rumah sakit khususnya petugas kesehatan lebih khususnya pada pasien yang sedang di rawat menggunakan ventilator.
EDİNİLMİŞ MALLARA KATILMA REJİMİNDE KATILMA ALACAĞI
Authors: KIRAN Berfin
Published: September 2022

Özet

Edinilmiş mallara katılma rejiminin 01.01.2002 tarihinden itibaren yürürlüğe girmesiyle birlikte mal rejimi konusunda önemli gelişmeler olmuştur. Edinilmiş mallara katılma rejimi, kadın-erkek eşitliği noktasında önemli fayda ve kazanımlar sağlamış olsa da uygulamada bazı zorluklar yaşanmaktadır. Bu makaleyi hazırlamadaki amacımız “Katılma Alacağı” konusunu doktrindeki görüş ayrılıkları ve Yargıtay kararları doğrultusunda incelemektir. Özellikle bazı konularda farklı görüşlerin olması uygulamada bir takım sorunları da beraberinde getirmektedir.

Amaç: Çalışmada, kanundaki değişiklik sonucu yasal mal rejimi olarak kabul edilmesiyle birlikte önemli noktaya gelen katılma alacağı konusunun incelenmesi amaçlanmıştır.

Yöntem: Çalışma hazırlanırken, edinilmiş mallara katılma rejimi hakkında genel bilgilendirme yapılmıştır. Katılma alacağı konusu ise ayrıntılı bir şekilde incelenmiştir. Ayrıca katılma alacağı konusunda tartışmalı noktalara yer verilerek hukuki niteliği incelenmiştir.

Bulgular: Katılma alacağının özellikle zamanaşımı konusunda bir çok görüş farklılığı bulunmaktadır. Ayrıca hesaplanma yönünde de bazı tartışmalı noktalar bulunmaktadır. Gerek doktrindeki gerekse Yargıtay’da bu sorunların önüne geçmek adına kanuni düzenlenmenin yapılması gerekmektedir.

Özgünlük: Katılma alacağı, konusunda bilgi sahibi olmak isteyenler için özgün bir makaledir.
KATILMA ALACAĞINDA ZAMANAŞIMI SORUNU
Authors: VAROL Begüm Gülberk
Published: September 2022

Evliliğin sona ermesiyle evlilik birliğindeki malvarlığı değerlerinin hakkaniyete uygun biçimde paylaştırılması gerekmektedir. Malvarlığı değerlerinin orantılı biçimde paylaştırılabilmesi için, eşlerin mal rejimi sona erdiğinde talep edebileceği birtakım alacak hakları bulunmaktadır. Eşler, tasfiye aşamasında, kural olarak evlilik süresince edindikleri “edinilmiş mallarının” yarısı üzerinde alacak hakkına sahiptir. Bu hak, artık değer hesabı yapıldıktan sonra çıkan miktarın yarısını oluşturan “katılma alacağı” olarak adlandırılmaktadır. Mal rejimi sona erdiğinde eşler “katılma alacağı” taleplerini mal rejiminin tasfiyesinden kaynaklanan davalar ile öne sürebileceklerdir. Amaç: Bu çalışmada, “katılma alacağının” talebine ilişkin zamanaşımı süresi ile ilgili öğretideki görüş ayrılıkları ve uygulamadaki son durumun incelenmesi amaçlanmıştır. Yöntem: Çalışmada “katılma alacağının” tâbi olduğu zamanaşımı süresine yönelik öğretide iki farklı görüş ayrılığına sebebiyet veren ilgili Türk Medeni Kanunu’nun 178. maddesi ve Türk Borçlar Kanunu’nun 146. maddesindeki zamanaşımı süreleri incelenerek Yargıtay uygulamasındaki son durum ile öğretideki görüş farklılıklarının gerekçeleri incelenmiştir. Bulgular: Mal rejiminin sona ermesinde “katılma alacağının” zamanaşımı süresinin Türk Borçlar Kanunu’nun 146. maddesi gereğince 10 yıl olması gerektiği yönünde ve Türk Medeni Kanunu’nun 178. maddesi gereğince 1 yıl olması gerektiği yönünde iki farklı görüş mevcut ise de Yargıtay TBK m.146 gereği 10 yıllık zamanaşımı süresini kabul etmektedir. Özgünlük: “Katılma alacağının” tabi olduğu zamanaşımı süresine yönelik görüş ayrılıkları neticesinde zamanaşımı süresi bakımından belirsizlikleri gidermek isteyen ve konu hakkında bilgi sahibi olmak isteyenler için özgün bir makaledir.
ELEKTRONİK ORTAMIN YABANCILIK UNSURU İÇEREN HAKSIZ REKABETTE UYGULANACAK HUKUKA ETKİSİ
Authors: İSLAMOĞLU Fatma
Published: September 2022

Teknolojide meydana gelen gelişmeler dünyayı küresel bir köy haline getirmiştir. Kitle iletişim araçlarının yaygınlaşması özellikle internet ağının dünya çapında her geçen gün genişlemesi zaman ve mekân sınırlarına takılmadan farklı tabiiyetlere mensup olan kişilerin daha kolay bir biçimde etkileşim içine girmesini sağlamıştır. Dünyanın her yerinden insanın etkileşim içinde olmasını sağlayabilen elektronik ortam ticari alanı da etkilemiştir. Ticari hayat içinde yeni bir pazar oluşturan elektronik ortam bu alanda yeni bir rekabetin var olmasına neden olmuştur. Klasik anlamda alışılagelmiş olan pazarlama ve reklam faaliyetleri ile diğer ticari davranışlar elektronik ortam içinde farklı bir boyut kazanmıştır. Elektronik ortamın zaman ve mekân sınırlarını kaldırmasını ticari faaliyetlerini sınır ötesi alanlara taşımasını sağlamış olsa da diğer yandan bu alanda meydana gelebilecek haksız rekabetin de etkisi de sınır ötesi olacaktır. Bu bakımdan yabancılık unsuru taşıyan haksız rekabete uygulanacak hukukun tespitinde elektronik ortam ve etkisi mevcut mevzuat ile değerlendirilmiştir.
RÜÇHAN HAKKININ KULLANIMINDA ARTAN PAYLARIN AKIBETİ
Authors: ÜLGEN Betül Büşra
Published: September 2022

ÖZET

6102 Sayılı Türk Ticaret Kanunu’nun m. 461 hükmü ile düzenlenen rüçhan hakkı, anonim şirket pay sahibinin, sermaye artırımı sonucu ihraç edilen payları, belli bir oran dahilinde satın almasını sağlar. Böylece pay sahibi, şirket içerisindeki oransal konumunu muhafaza eder. Rüçhan hakkının kullanılması için, her sermaye artırımı kararı sonrasında kural olarak, hakkın kullanım süreci de gerçekleşecektir. Ancak rüçhan hakkı, her zaman tüm pay sahiplerince kullanılmamaktadır. Bazen de rüçhan hakkına kısıtlama getirilir ve kısıtlama kararına rağmen ortaya çıkan paylar satın alınmaz. Bu durumda, artan payların akıbetinin ne olacağı sorusunun cevaplanması gerekir.

Amaç: Bu makalede, rüçhan hakkıyla ilgili genel bilgiler verildikten sonra, artan payların akıbeti hakkındaki sorun incelenmeye çalışılacaktır.

Yöntem: Literatür araştırmasına dayanan bu çalışmada, rüçhan hakkına yönelik yasal düzenlemeler ve öğreti görüşleri incelenmiştir.

Bulgular: Türk Ticaret Kanunu rüçhan hakkını tek bir madde ile düzenlemiştir. Bunun yanında rüçhan hakkı ile doğrudan doğruya bağlantılı hususlarda da rüçhan hakkına yönelik atıflar bulunmaktadır. Ancak rüçhan hakkının kullanımı sonucunda artan payların akıbetine ilişkin açık bir düzenleme bulunmamaktadır.

Özgünlük: Bu çalışmada rüçhan hakkının kanuni kullanımı ve hakkın kullanımının kısıtlanması ihtimalleri ayrı ayrı incelenmiştir. Ayrıca esas sözleşme, genel kurul ve yönetim kurulunun olası yetkilerine değinilmiştir.
TIP CEZA HUKUKU BAĞLAMINDA KÖK HÜCRE ÇALIŞMALARI VE SORUNLARI
Authors: İÇEL Kayıhan , HEPVAR Metehan
Published: September 2022

Amaç: Farklı hücre tiplerine dönüşebilme ve kendini yenileyebilme potansiyeline sahip olan kök hücrelerin bazı türlerinin, uygun koşullarda insan vücudundaki tüm hücrelere dönüşebileceği tıbben öngörülmektedir. XX. yüzyılın ortasından itibaren yapılan çalışmalar, bu hücrelerin çeşitli hastalıkların tedavisinde kullanılabileceğini göstermiştir. Ancak insan embriyosu kullanılarak elde edilen kök hücre çalışmaları birtakım hukuki ve ahlaki sorunları da beraberinde getirmiştir. Bu makalemiz, kök hücre çalışmalarını tıp ceza hukuku bağlamında ele almayı ve bu konudaki hukukî sorunlara farklı ülkelerin hukukunda getirilen çözüm önerileriyle karşılaştıralı şekilde Türkiye’deki hukuki durumu ele alarak konuyla ilgili sorunları ortaya koymayı ve olası çözüm önerilerine işaret etmeyi amaçlamaktadır.

Yöntem: Çalışmada öncelikle kök hücre kavramı, tür ve tasnifleri açıklanmış, ardından bu konudaki temel hukuki sorunlar irdelenmiştir. Son olarak ise çeşitli ülkelerin hukuklarında ve Türk hukukunda kök hücre çalışmalarıyla ilgili yasal düzenlemeler ele alınarak, bunlara ilişkin değerlendirme ve önerilerde bulunulmuştur.

Bulgular: Her ne kadar embriyonik kök hücre çalışmalarına dair bazı uluslararası hukuki düzenlemeler mevcutsa da ülkelerin bu soruna yönelik düzenlemeleri ve yaklaşımları farklılık göstermektedir. Türkiye’de kök hücre çalışmalarına ilişkin belirli yasal düzenlemelere ihtiyaç olduğu kanısına varılmıştır.

Özgünlük: Kök hücre çalışmalarına ilişkin çeşitli ülkelerin hukukî düzenlemeleri bu çalışma tarafından tasnif edilmeye çalışılmış, yakın zamanda konuyla ilgili mevcut gelişmeler ışığında önerilerde bulunulmuştur.
Insights About NTRK Gene Fusion Testing and TRK Inhibitors Comparative Effectiveness for Best Clinical Practice
Authors: Ibrahim Nagwa
Published: September 2022

Precision medicine aims to identify the genetic landscapes of each patient's cancer to maximize effectiveness and minimize toxicity to normal cells. Due to the efficacy of tropomyosin receptor kinase (TRK) inhibitor therapy, it is currently clinically recommended to identify patients with neurotrophic tropomyosin receptor kinase (NTRK) fusion-driven cancer. In this article we aim to provide perceptions to enhance best clinical practices about NTRK gene fusion testing and monitoring parameters for the approved TRK inhibitors as well as its comparative effectiveness based on previously published articles and guidelines. Identification of NTRK gene fusion may be attained using different methods based on histology and molecular findings. The possible methods for detection are immunohistochemistry, fluorescence in situ hybridization, reverse transcriptase polymerase chain reaction and next generation sequencing. FDA approved two TRK inhibitors Larotrectinib and Entrectinib. Based on management guidelines, oncologists have one opportunity to decide which TRK inhibitor to choose for patients. There is no direct comparison in clinical trials and Larotrectinib versus Entrectinib comparative efficacy still unclear. In addition, cross-trial comparisons are susceptible to potential biases. Indirect comparative efficacy of Larotrectinib (Vitrakvi) versus Entrectinib (Rozlytrek) was conducted by Jesus Garcia-Foncillas and colleagues. The matching-adjusted indirect comparison (MAIC) to compare the 2 agents was utilized. They assumed this model would aid to balance baseline characteristics and facilitate cross-trial comparisons. The published findings propose favorable efficacy for Larotrectinib in regard to OS and PFS and comparable ORR and safety profiles compared to Entrectinib in treating TRK fusion positive cancer. In conclusion, further research should re-assess the comparative effectiveness of both TRK inhibitors as long-term survival data mature and increased number of patients are treated. Furthermore, data with longer follow up times will further enlighten this comparison.
Pengaruh Machiavellian, Kecerdasan Spiritual Terhadap Perilaku Etis Apip Dengan Budaya Organisasi Sebagai Variabel Mediasi (Studi Kasus Pada Inspektorat Kota Bukittinggi)
Authors: Fauzan Ahmad , Yulihasri Yulihasri
Published: September 2022

The Inspectorate is one of the public sector local government organizations that aims to monitor and observe what is actually happening and compare it with what should have happened. If it turns out that there are deviations or obstacles, it is hoped that they can be immediately identified, so that corrective action can be taken immediately. Through this corrective action, it is hoped that the implementation of the activities concerned can still achieve its objectives to the fullest. The research subjects were employees of the Bukittinggi City Inspectorate. A sample of 35 employees was determined using the proportionate stratified random sampling technique. This type of research is quantitative research. Data collection techniques using a questionnaire with a Likert scale model of 5 alternative answers. Data analysis was performed using SEM (Structural Equation Modeling) analysis which was operated based on Partial Least Square (PLS) with two independent variables, one dependent variable and one mediating variable. This study results that machiavellian nature has a negative effect on ethical behavior with organizational culture as a mediating variable, while spiritual intelligence has a positive effect on ethical behavior with organizational culture as a mediating variable at the Inspectorate of Bukittinggi City.
Sistema integral de formación para la enseñanza de la investigación
Authors: Franco Montoya Juan Carlos
Published: September 2022

La pregunta por la universidad ha venido cobrando relevancia y se podría afirmar que en la actualidad ha tomado diferentes matices, ya que campos disímiles han asumido dicha interrogante para su reflexión y crítica. Ahora bien, en la perspectiva de las ciencias sociales y humanas se ha venido reflexionado con relación a los llamados «problemas de primer orden en la universidad», dentro de los cuales se pueden categorizar todos aquellos que tienen que ver con los procesos configurados al interior de la institución en cuanto a sus funciones sustantivas basales: docencia, investigación, extensión y sus interacciones con sus emergentes y, por otro lado, las funciones de gestión, que tienen un carácter más administrativo y directivo pero permean directa o indirectamente las anteriores. Otros tipos de problema, denominados «de segundo orden», se relacionan con aquellas afectaciones que recibe la universidad desde otros sistemas (político, económico, cultural, religioso, científico, de salud) y hacen que ella sufra alguna especie de transformación o, en términos de Luhmann (1996a; 1998b), algún tipo de «irritación» que la perturba de forma directa o indirecta y genera en su interior una especie de cambios o mutaciones que la obligan a adaptarse a las nuevas condiciones.
Habilidades para la vida
Authors: Álvarez-Fonseca Fredy Yoverti , Correa-Carmona Juan Carlos , Henao-Giraldo Juan David , Sánchez-Marín Yeizon Fabián , Serna-Velásquez Natalia
Published: September 2022

Las habilidades para la vida remiten a los comportamientos aprendidos por los seres humanos que son incorporados por la vía de la experiencia o la formación recibida en el contexto natural o a través de un medio institucionalizado, como la escuela o el colegio, a través de los cuales enfrentamos las situaciones problemáticas que plantea la vida cotidiana (Gobernación de Antioquia, 2009). Desde la perspectiva de la Organización Panamericana de la Salud (ops), estas habilidades se asocian a «las destrezas que contribuyen a que los adolescentes adquieran las aptitudes necesarias para el desarrollo humano y para enfrentar en forma efectiva los retos de la vida diaria» (Organización Panamericana de la Salud [ops], 2001, p. 5) y se inscriben en las dimensiones: social (comunicación, empatía, control de la agresividad y el rechazo); cognitiva (toma de decisiones, autoconocimiento) y emocional (autocontrol y manejo del estrés). El presente material didáctico se inscribe en la perspectiva desarrollada por laOPS, en el sentido de trabajar por el fortalecimiento de las habilidades de autoconocimiento, comunicación, trabajo en equipo y autocontrol de los niños y niñas en la etapa de la segunda infancia (6 a 12 años de edad), a través de reflexiones y actividades que involucran no solo a los infantes, sino también a los miembros de su ambiente familiar (padres, hermanos o personas 8 responsables de su cuidado). Todo ello cimentado en el supuesto de que la formación para la ciudadanía no es un proceso aislado, a la manera de un enclave inscrito en un todo orgánico societal, sino un devenir fortalecido por el sentido de la alteridad, el encuentro y desencuentro con unos y otros seres humanos.
Declaração de Cartagena e os Desafios para os Direitos Humanos de Pessoas Refugiadas na América Latina
Authors: Rego de Paiva Ariane , De Paiva Gonçalves Ana Gabriela
Published: September 2022

O artigo apresenta a intersecção entre o sistema de proteção internacional de Direitos Humanos e o sistema de proteção internacional aos refugiados, com ênfase nos aspectos regionais da América Latina e suas contradições no capitalismo contemporâneo. Utilizaram-se de análise bibliográfica e de documentos para apontar os principais avanços na proteção regional a partir da Declaração de Cartagena e, em seguida, analisar os desafios atuais de proteção às pessoas em situação de refúgio na América Latina.
"Fique em casa"? a retórica do direito à moradia no contexto da pandemia da Covid-19 no Brasil
Authors: Lopes Cortes Thaís
Published: September 2022

O presente artigo tem como objetivo discutir o direito fundamental à habitação, no contexto da pandemia da Covid-19 no Brasil. Partimos do reconhecimento que, historicamente, a política habitacional se constitui enquanto um instrumento de manutenção de privilégios para a acumulação capitalista, ao fomentar processos de remoções, que coadunam no empresariamento urbano. Intentamos demonstrar que tal lógica permaneceu intocável durante a crise pandêmica. Para tanto, buscaremos analisar a intervenção do Estado, que tem se pautado numa série de expropriações, que conjugam as remoções e o desfinanciamento dos programas habitacionais em curso. Não sem lutas é que essas expropriações têm se consolidado, haja vista, a resistência dos movimentos sociais urbanos. Este estudo integra as reflexões realizadas no Programa de Estudos de América Latina e Caribe (PROEALC/UERJ).
Direitos Humanos na América Latina: história, política e lutas sociais
Authors: Barcellos Gilsa Helena , Amilton de Almeida José , De Moraes Freire Silene
Published: September 2022

Apresentação do dossiê "Direitos Humanos na América Latina: história, política e lutas sociais"
Vitamine D voor kinderen in Vlaanderen
Authors: Raaijmakers A. , Van Winckel M. , Plaete J. , Bovijn L. , Van Overmeire B. , Vandenplas Y. , Arts W. , De Greef E. , Declercq D. , Veereman G. , Hauser B. , Hebbelynck J. , Huysentruyt K. , Vyncke K. , Neven L. , Stevens G.
Published: September 2022

Vitamin D for children in Flanders

Vitamin D plays a pivotal role in calcium/phosphate homeostasis and a subsequent healthy bone metabolism. In addition, vitamin D potentially has many other functions like a role in the regulation of the immune system. Across Europe, there is consensus to supplement infants under 1 year of age with (at least) 400 IU of vitamin D. However, there is no consensus regarding vitamin D supplementation for older children (as well as the desired levels of 25-OH vitamin D). Endogenous synthesis of vitamin D in the skin takes place under the influence of UVB sunlight. Therefore, in healthy fair-skinned children who spend sufficient time outdoors, a supplement is not necessary, yet harmless. The number of children at risk of deficiency has increased. Risk factors for vitamin D deficiency are dark skin, veiling, the use of complete sun-blocking agents and spending most time indoors. A uniform and straightforward recommendation could increase compliance. Therefore, the Vitamin D working group of the Flemish Association of Pediatricians confirms the recommendation of a universal supplementation of at least 400 IU per day for all children from birth until 6 years. In children with risk factors, this daily supplementation is advised until 18 years of age (and older) and an even higher supplemental dose could be considered. Dosing of serum 25-OH vitamin D as a screening test in healthy children is not recommended. This article should be considered as a narrative review with conclusions based on expert opinion, due to the limited evidence on this topic.
The Implementation of Self-Directed Dialogue to Improve Students’ Speaking Ability
Authors: Nova Melia , Syarifudin Syarifudin , Ariawan Soni
Published: September 2022

The purpose of this study was to find out the improvement of students speaking ability through the implementation of the self-directed dialogue technique, and student activities when the Self-directed Dialogue was applied to English subjects in the first grade of MA Darussalam, Beremi for the 2021/2022 academic year. In this study, the researcher used classroom action research as a research design by employing observation, tests, and documentation as techniques to gain the data. Observations were made to determine the application of self-directed dialogue techniques during the teaching and learning process while tests were used to measure student achievement in speaking ability. The subjects of this study were students in first grade of MA Darussalam Bermi with 21 students in the class. Researchers used qualitative and quantitative data analysis in calculating and analyzing data. The results of this study indicate that the self-directed dialogue technique can improve students' speaking ability. This can be seen from the results of a significant increase in each cycle. The score before implementing the technique was 48, the result of post-test 1 was 74.43, and post-test 2 was 84.43. This means that the students' speaking ability increases after applying the self-directed dialogue technique in the first grade of MA Darussalam Bermi in the 2021/2022 academic year.
Motives, Problems, and Reforms in Transnational Higher Education: A Case Study of SUCs in The Philippines
Authors: Bombita Medardo B.
Published: September 2022

This study examines the transnational higher education in the Philippines using sequential exploratory mixed design based on document analysis, and tools to conduct cross-sectional survey. The survey was developed and standardized interview was adopted where results were transcribed and coded for emerging themes. Four research questions guided this study: 1) What are the motives of international mobility of students? 2) What are the problems met by Filipino international students; 3) What actions taken by SUCs to address concerns of mobile students; and 4) What recommendations can be offered to better enhance the transnational higher education in the Philippines. The results exhibited challenges still persist that hinder transnational higher education programs, notwithstanding the long-term consequences of COVID-19. Most SUCs included internationalization in institution’s policies and plans to be compliant with the SUC levelling, quality assurance assessments and responding to the ASEAN regional integration. Adoption of open and distance learning (ODL) as part, or an alternative modality of internationalization of higher education under RA 11448 is timely and pragmatic.
Captured Moments of Landscape Metamorphosis
Authors: Schmitzer Valentina , Gerdin Tim , Ilersic Ria , Zaucer Anja , Kregar Tršar Mateja
Published: September 2022

Landscape architecture students at the University of Ljubljana were encouraged to prepare temporal series of landscape and plant drawings to sharpen their sensitivity to changes in the perception of a land motive and vegetation morphology. Students chose a particular motive, defined the frame of the drawing, and identified characteristic plants on site. The motives were sketched several times during the year to portray seasonal changes. Specific environmental conditions (fog, rain, sunny day) were captured in drawings, and in the case of plants, drawings revealed the transitions of selected physiological events (budding, flowering, fruiting). These transformations were discussed in connection with landscape perception and as a tool in the design process.
El Camino Desdibujado. Ser y Tiempo en los Cuadernos Negros
Authors: Yáñez Ángel Xolocotzi
Published: September 2022

Tras el inicio de la publicación de los llamados Cuadernos negros de Martin Heidegger, a partir de 2014, se pueden constatar, con mayor claridad, algunos aspectos autocríticos frente a lo expuesto en Ser y tiempo, de 1927. A partir de un análisis de los documentos hasta ahora conocidos es posible reconstruir a detalle cuáles fueron los motivos por los que Heidegger, entre 1931-1932, planteó una crítica al proyecto de la ontología fundamental y abandonó el plan de redacción de la segunda parte de Ser y tiempo, en favor de un camino que lo llevaría a la senda del pensar ontohistórico. Con base en los nuevos materiales aportados por los Cuadernos negros es posible cuestionar una serie de interpretaciones apresuradas que rápidamente hablaron de un “fracaso” en el proyecto de Ser y tiempo.
A Fenomenologia Antropológica de Binswanger
Authors: De Feijoo Ana Maria Lopez Calvo
Published: September 2022

Neste estudo procedemos a uma revisão narrativa da literatura, de modo a mostrar as diferentes etapas da psiquiatria tal como desenvolvida por Ludwig Binswanger, ao mesmo tempo realizamos uma análise crítica dessas etapas.  Discorremos sobre os motivos do afastamento desse estudioso das bases biológicas que sustentavam a psiquiatria da época, em direção a uma perspectiva psicanalítica. Nessa etapa, Binswanger defende as bases psíquicas das enfermidades mentais, das quais em breve tempo também se afasta por avaliar que na psicanálise, também, havia uma redução ao psíquico. Esse estudioso passa, imediatamente, para os estudos das bases fenomenológicas com seu mestre Edmund Husserl, acreditando que nessa perspectiva ficaria livre de qualquer redução. Em um breve intervalo de tempo, esse estudioso da psiquiatria passou a estudar a analítica do Dasein com Martin Heidegger, assumindo a Daseinsanalyse nas bases de seus estudos. No entanto, com a crítica de Heidegger à daseinsanálise de Binswanger, este acabou por denominar o seu projeto de psiquiatria como fenomenologia antropológica, interessando-se pelas vivências do espaço e do tempo daqueles que apresentavam enfermidades psíquicas.
Gabriel Marcel: La Metafísica ante la Muerte
Authors: Grassi Martín
Published: September 2022

En el presente trabajo intentaremos mostrar cómo la experiencia de la muerte pone en jaque la categoría metafísica de presencia, que se encuentra en el corazón de la obra de Gabriel Marcel. A diferencia de otras filosofías de la existencia, la significación metafísica de la muerte no la encontramos en la conciencia de la muerte propia, sino en el acontecimiento de la muerte de la persona amada. Por esta razón, el sentido de la muerte solo es inteligible en el marco de la experiencia de la fidelidad y del amor, y su carácter trágico reside en que parece deslegitimar la promesa de eternidad en la comunión de los amantes y la consistencia ontológica de la existencia. Lejos de ser extraño al ritmo dramático de la filosofía marceliana, la reflexión en torno a la muerte subraya la necesidad de pensar la presencia en conjunción con la ausencia, lo cual nos abre a una filosofía que trasciende el ser entendido como presencia y apariencia, para abrazar lo inaparente como lo realmente significativo. De este modo, encontramos la radicalización de la fenomenología como hiperfenomenología en la propuesta de Gabriel Marcel, quien podría considerarse uno de los iniciadores de la tradición que hoy recibe el nombre de “giro teológico de la fenomenología”.
O Significado da Crise da Sociedade Contemporânea
Authors: Furlan Reinaldo
Published: September 2022

O objetivo do artigo é trazer o debate de alguns autores sobre a crise atual da sociedade ocidental contemporânea, a partir de três questões que nos parecem discriminar parte considerável dos seus principais problemas: a autonomização da economia, a razão instrumental e a decadência cultural. Com a primeira e a segunda questão se acusam os riscos da separação da economia, da ciência e da técnica diante das necessidades da vida, e com a terceira se acusa nosso estado atual de impotência para responder a tais desafios. O objetivo é fomentar a discussão crítica desses problemas, que nos parecem questões incontornáveis no presente de nossas vidas.
Intuição categorial e evidência, verdade e ser
Authors: Fernandes Marcos Aurélio
Published: September 2022

Este artigo se propõe a pensar a fenomenologia dos fenômenos: intuição categorial, evidência,verdade e ser, através da interpretação de textos de Husserl e Heidegger. Num primeiromomento mostra a intuição em sua maior pregnância, a percepção, como experiência daevidência da presença do ente mesmo como autodatidade originária. Num segundo momento,partindo da regionalidade e da universalidade da evidência na vida intencional da consciência,trata-se da razão, de seu ordenamento para a evidência e de sua correlação com a verdade e oser. Num terceiro momento se realiza uma interpretação fenomenológica da doutrinatradicional da verdade como adequação e se intenta mostrar que esta concepção de verdade éderivada e se deixa reconduzir à verdade como manifestação do ser do ente. Num quartomomento discorre-se a respeito de dois significados de ser: ser no significado de serverdadeiroe ser na função da cópula. Por último, tenta-se acenar para a evidência do ser epara o relacionamento humano em face dela.
Existência, liberdade e possibilidade: considerações sobre a crítica ao determinismo em Sartre
Authors: Mendonça Magdalena
Published: September 2022

A partir das noções de liberdade, situação e responsabilidade e suas relações, apresentadanos textos sartrianos aqui escolhidos – a saber: O existencialismo é um humanismo e O ser eo nada –, objetiva-se destacar a crítica à doutrina do livre-arbítrio, própria do pensarcristão, que acarreta a recusa do pensar determinista em Sartre a respeito das ações econdutas humanas, sobretudo no destaque que o filósofo confere aos termos situação econtingência, vinculadas à sua compreensão de liberdade. Trata-se de sinalizar, na ênfasedo valorar singular enquanto compreendido como próprio do humano, a suaconsequência: a recusa do caráter transcendente das ideias de bem e mal, virtude ou vício,que não deixam de apontar para uma concepção ética na visão sartriana da existênciahumana e do modo de agir e posicionar-se no mundo. Em síntese, a motivação maior sevolta para a reelaboração da moral para além do pensar cristão, que acentua a implicaçãodo sujeito no seu fazer-se, a sua responsabilidade em relação aos acontecimentos eprojetos que eliminam a passividade e a indiferença na ação e no posicionamento do parasino mundo, que a ele se apresenta e nele ele se revela.
Creusa Capalbo (1934 – 2017): O Elogio à Historicidade
Authors: Silva Claudinei Aparecido de Freitas da
Published: September 2022

Mediante um breve recorte, presto, no que se segue, uma singela homenagem à recémfalecida professora doutora Creusa Capalbo (1934-2017), importante difusora intelectualquanto aos estudos fenomenológicos no Brasil. Para tanto, chamo a atenção para um dosconceitos-chave mais trabalhados em sua produção: a noção de historicidade.