bluuebunny/crossref_metadata_2025 huggingface dataset:
Unifikasi Kelompok Keagamaan Islam Berbasis Multi Interdisipliner menuju Masyarakat Madani
Authors: Rohman Abdul , Nurlaela Nurlaela , Munasib Munasib
Published: March 2024

The purpose of this article is to reveal the problems of friction, conflict, and divisions that occur among Muslims, which are spread across several groups such as Nahdlatul Ulama, Muhammadyah, Jama'ah Islam, Tabligh Jama'ah, Salafi, and Ahmadiyah. In general, each group claims to be the most correct group, so they are trapped in bigotry based on their group, doctrin, tafwa, or their leaders. The method of this study is based on library research in which the approach is carried out in a multi-disciplinary manner, namely through the science of interpretation, hadith, ushul fiqh, and sociology. The method of this study is based on library research in which the approach is carried out in a multi-disciplinary manner, namely through the science of interpretation, hadith, ushul fiqh, and sociology. The results of the study found: 1) Islam highly upholds unity within the ummah. The prohibition of division has been imposed since the time of the prophet before the Prophet Muhammad was sent to the world. Therefore the existence of religious groups should be to strengthen people and religion, so as to try to avoid the perception of a single truth claim, so as not to be trapped in the fanaticism of the group, schools of thought, tafwa, as well as towards their leaders; 2) Unification of religious groups can occur if it is based on intellectual awareness. Because this awareness can penetrate across ideologies, ideologies, schools of thought, and/or cultures. Without this awareness, unification is difficult to achieve; and 3) Intellectual awareness can be achieved through intellectual collaboration between religious group leaders. In fact, this intellectual awareness is a gateway to civil society, which has the characteristics of being open to knowledge, egalitarianism, and equality in the community, respecting human rights, respect for achievements, and being highly civilized and abandoning primordial attitudes.
Membangun Insan Akademis Yang Bijak Dan Cerdas Bermedia Sosial Di Era Digital Literasi dan Informasi Pada Siswa SMKN 2 Palangka Raya
Authors: Triyani Triyani Triyani , Dotrimensi Dotrimensi , Firman Firman , Suryadi Suryadi
Published: March 2024

Pengabdian kepada masyarakat yang dilaksanakan ini bertujuan untuk pertama, meningkatkan pengetahuan, keterampilan dan wawasan siswa SMK N 2 Palangka Raya dalam menggunakan media sosial. Kedua, meningkatkan pemahaman dan pengetahuan siswa SMK N 2 Palangka Raya tentang literasi media dan informasi. Dengan adanya sosialisasi terkait bijak dalam bermedia sosial diharapkan para siswa memiliki kesadaran yang utuh  dalam menggunakan media sosial, etika bermedia sosial yang baik dan benar, dan cermat dalam memvalidasi berita yang berimbang. Hasil kegiatan pengabdian ini para siswa mendapatkan bekal pengetahuan pemahaman dan keterampilan dalam menggunakan media sosial. Dibutuhkan sikap yang bijak dan cerdas dalam memainkan media sosial agar  tidak memberikan dampak negatif pada masyarakat.
IMPACT OF THE PREVIOUS 2019 NOVEL CORONAVIRUS INFECTION ON THE STRUCTURAL AND FUNCTIONAL PARAMETERS OF THE RIGHT HEART AND ON PULMONARY HEMODYNAMICS IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors:   Аmur State Medical Academy, KULIK EKATERINA G. , PAVLENKO VALENTINA I. ,   Аmur State Medical Academy, BAKINA ANASTASIA A. ,   Аmur State Medical Academy, NARYSHKINA SVETLANA V. ,   Аmur State Medical Academy
Published: March 2024

Abstract. Introduction. This paper presents the interim results of a prospective clinical study, in which we studied the long-term inﬂuence of 2019 novel coronavirus infection (2019-nCoV) on pulmonary-cardiac relationships in patients with chronic obstructive pulmonary disease. Aim: Studying the eﬀect provided by the previous 2019-nCoV on the structural and functional parameters of the right ventricle of the heart and on pulmonary hemodynamics in patients with chronic obstructive pulmonary disease. Materials and Methods. Over the years 2021-2023, we examined 43 patients with stable chronic obstructive pulmonary disease, having a history of 2019-nCoV by transthoracic echocardiography. The study consisted of two control points: on day 8-12 in the hospital and the follow-up visit to the clinic 12 months after 2019-nCoV. The study included a control group of 30 stable chronic obstructive pulmonary disease patients having no 2019-nCoV history. Results and Discussion. We found that the structural and functional strains of the right heart are aggravated in the acute period of 2019-nCoV in patients with chronic obstructive pulmonary disease. Thus, as compared to the control group, the maximum right atrium width (p<0.05), right ventricle anterior wall thickness (p<0.05), and basal right ventricle diameter values were signiﬁcantly higher. Echocardiographic signs of right ventricle diastolic dysfunction Type 1 were found in 36,3% of cases and Type 2 in 23.3%. Pulmonary artery diameter and mean pulmonary artery pressure were higher than in those of the control group, as well. In 44% of patients, the value of pulmonary artery acceleration time was less than 105 ms (χ2 = 4.59; p<0.05). Persistently high linear and volumetric right atrium and right ventricle indicators were registered in patients after 12 months of follow-up. Signs of the Type 1 diastolic dysfunction were found in 62.7% of patients. There was a tendency to decrease the mean pulmonary artery pressure and pulmonary artery acceleration time values. Conclusions. Thus, according to echocardiography, the combination of chronic obstructive pulmonary disease and 2019-nCoV leads to the aggravation of right ventricle diastolic dysfunction and the progression of pulmonary hypertension. These signs persisted for a long time (12 months).
Freud’s Psychoanalysis Perspective on the Characteristics of the Monster in Frankenstein
Authors: Shen Fanxi
Published: March 2024

The famous English writer Mary Shelley wrote Frankenstein in 1818, which is regarded as the world’s first science fiction novel, and thus Mary Shelley was awarded the title of Mother of Science Fiction. With a gothic plot, this novel contains the philosophy of technology, psychology and epistemology, expressing the author’s exploration of human nature. The psychological and action descriptions of the characters in this novel, to a certain extent, show the psychological characteristics of the character’s id, ego and superego. Therefore, this paper will elaborate the psychological characteristics of the characters from the aspects of id, ego and superego from Freud’s psychoanalysis theory, thus exploring the character traits of the novel and providing a new perspective for the interpretation of the novel.
Ideal Timing of Reimplantation in Patients with Periprosthetic Knee Infection Undergoing 2-Stage Exchange
Authors: Ascione Tiziana , Balato Giovanni , Festa Enrico , Pandolfo Giuseppe , Siciliano Roberta , Pagliano Pasquale
Published: March 2024

Background:

This study evaluated appropriate thresholds for serum biomarkers, synovial fluid white blood cell (SF-WBC) count, and synovial fluid neutrophil (polymorphonuclear leukocyte [PMN]) percentage to predict infection in a patient group who underwent definitive reimplantation after receiving a continuous course of antibiotic therapy for chronic knee periprosthetic joint infection (PJI). These thresholds were then used to generate a scoring system to predict recurrence (or persistence) of infection.

Methods:

The study included 153 patients with a median age of 73 years (range, 46 to 91 years) who underwent 2-stage revision for chronic knee PJI. Staphylococci were identified at baseline in 107 (70%) of the patients. After the 96-week follow-up period, 12% (19) of the 153 patients had recurrence of the PJI. A receiver operating characteristic (ROC) curve analysis was used to assess the predictive value of common serum biomarkers and SF aspiration before reimplantation, and the area under the curve (AUC) was evaluated. Variables that were significantly different between patients with and without infection recurrence were evaluated using a multivariable logistic regression model. A half-integer-point scoring system was created based on the final beta coefficients.

Results:

Regarding the prediction of recurrent infection, a D-dimer level of >1110 ng/mL yielded a sensitivity of 74%, specificity of 61%, and AUC of 0.69; an SF-WBC count of >934 cells/µL showed a sensitivity of 68%, specificity of 90%, and AUC of 0.79; and an SF-PMN percentage of >52% showed a sensitivity of 73%, specificity of 90%, and AUC of 0.82. The beta coefficients were approximated to 1.5 for the D-dimer level and to 2 for the SF-WBC count and SF-PMN percentage. A total score of >2 was used to classify patients with a high risk of infection recurrence. The ability to discriminate infection recurrence was demonstrated by an AUC of 0.90 (95% confidence interval: 0.82 to 0.99).

Conclusions:

Patients with a score of >2 on our proposed scoring system based on serum biomarkers, SF-WBC count, and SF-PMN percentage should not undergo reimplantation, as they are at a high risk for recurrent PJI. Patients with a score of ≤2 can undergo definitive reimplantation with the lowest risk of recurrence.

Level of Evidence:

Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
The Effect of Teleeducation Methods on Level Knowledge and Attitudes about HIV/AIDS Student in Ciasem 1 Public High School
Authors: Suciyanti Suciyanti , Indahwati Lilik , Iffah A. Krisjentha
Published: March 2024

HIV/AIDS is one of the major global health problems. Approximately, 5 percent of all HIV cases are originated from adolescents and around 1.7 million adolescents worldwide are living with HIV in 2019. Adolescents are often less exposed to information related to reproductive health, including HIV/AIDS. The purpose of this study is to determine the effects of the teleeducation method on the level of knowledge and attitudes of adolescents about HIV/AIDS. The research design used in this study was pre-experimental designs with one group pretest-posttest approach. Reproductive health education with the teleeducation method is carried out for 1 day. The data was collected using questionnaires that were distributed before and after the teleeducation was given. The number of respondents that was taken for this study were 78 students who were taken using purposive sampling technique. The results of the non-parametric two-related sample test using the Wilcoxon test in the knowledge analysis showed that the p-value was 0.000 or (p-value < 0.05) and the attitude analysis using the Wilcoxon test found that the p-value was 0.000 or (p-value < 0.05), indicating that there are differences in knowledge and attitudes before and after the teleeducation method was given. It can be concluded from this study that there are effects of the teleeducation method on increasing knowledge and increasing adolescent attitudes about HIV/AIDS.
Assembly and Installation of SDP Lighting Panels
Authors: Rohman Rizky Habibur , Anshory Izza
Published: March 2024

Electrical panels have an important role in distributing electrical energy and securing it. One type of electrical panel that is often used is the SDP Panel (Sub Distribution Panel), especially in the context of lighting. This article discusses the assembly and installation process of SDP Lighting Panels, which have a crucial role in maintaining the availability, efficiency and safety of lighting systems. The SDP Panel assembly process involves preparing components such as MCB (Miniature Circuit Breaker), MCCB (Moulded Case Circuit Breaker), Fuse , ELCB (Earth Leakage Circuit Breaker), and other components. After that, these components are carefully assembled according to the previously prepared design. Next, SDP Panel installation involves installing the panels to a location according to the plan and connecting them to the building's main power system. Accurate wiring and thorough testing are necessary to ensure that the panels function properly. It is important to understand that SDP Lighting Panel installations must comply with applicable electrical safety regulations and standards to avoid the risk of fire, electrical disturbances or injury. Errors in the installation or assembly process can have a negative impact on the lighting system and safety. Therefore, a good understanding of the SDP Lighting Panel assembly and installation process is very important to ensure a reliable, efficient and safe lighting system
Capacitor Bank Panel Design to Improve Industrial Power System Efficiency and Safety
Authors: Adhimanata Yogi , A Shazana Dhiya
Published: March 2024

Industrial loads generally use control equipment and power electronics that use semiconductor materials that are very sensitive to voltage fluctuations. As reactive power compensation, industries usually use capacitor banks to increase power factor, reduce losses and increase line capacity. But it turns out that the use of capacitor banks also causes problems related to capacitor bank switching during the energizing process. During the energizing process, transient voltages and currents will be generated which can potentially damage control equipment, power electronic equipment, switching equipment and the capacitor bank itself. The Capacitor Bank panel assembly process involves the preparation of components such as MCB (Miniature Circuit Breaker), MCCB (Molded Case Circuit Breaker), Capacitor Bank, and other components. After that, these components are carefully assembled according to the pre-prepared design. Next, the installation of the Capacitor Bank panel involves mounting the panel to the location according to the plan and connecting it to the building's main power system. Accurate wiring and meticulous testing are required to ensure that the panels function properly. Therefore, a good understanding of the assembly and installation process of Capacitor Bank panels is essential to ensure efficient, and safety.
Analysis Of Shoe Product Quality Control At PT XYZ
Authors: Arzaq Miftah , Arzaq Rahmansyah M. Miftah , Wulandari Indah Apriliana Sari
Published: March 2024

PT XYZ is a company located in East Java, Indonesia. The company is engaged in manufacturing footwear such as shoes and sandals using the latest technology, namely injection molding. As a company engaged in the field of footwear, of course PT XYZ always prioritizes quality control to ensure the quality of products that have been produced by not neglecting quality control in every production process. The daily production capacity of PT XYZ using 7 machines is 2000 - 3000 pairs of shoes for each machine and, if 7 machines then the production that can be produced in 1 day can range from 15,000 - 21,000 pairs every day. With a very high production capacity PT XYZ still controls the quality of shoes using the six sigma method.
Wiring Diagram For The Ventilation Panel
Authors: Rochman Achmad Fatchur , Wisaksono Arief
Published: March 2024

Wiring diagrams are an essential tool in the maintenance and repair of electrical systems, enabling quick identification of the source of the problem. Knowledge of electrical component symbols and their functions is important in reading wiring diagrams. Ventilation systems play a crucial role in closed environments such as chicken coops, maintaining air circulation and appropriate temperatures. Settings can be made automatically via the climate controller and control panel. Therefore, a basic understanding of the use of these devices is important for breeders. The research method used is descriptive qualitative with data collection in the field, especially at CV. Bintang Pratama Teknik, to study ventilation panels from wiring drawing in AutoCAD to assembly. The research results include an understanding of components such as electrical panels, AutoCAD, MCB, TOR, contractors, busbars, duct cables, and terminals. Drawing components using AutoCAD allows a better understanding of their design and functionality.
Mitasaqan Ghaliza's Concept as a Solution to the Feminist Perspective on the Concept of Marriage
Authors: Shalahuddin Henri , Hidayat Muhammad Sofian , Nugroho Allam Setiawan , Tsaqib M Ammar , Jamil Ahmad
Published: March 2024

Abstrak: Dinamika kehidupan manusia sejatinya sangat berkaitan dengan worldviewnya terhadap dunia. Tak terkecuali dalam ranah pernikahan dan keluarga. Femisme dengan cara pandangnya menganggap pernikahan dan keluarga hanya sebatas kepentingan dan kepuasan manusia saja bahkan pernikahan hanya membawa kesengsaraan, ketertindasan bagi perempuan. Sejalan dengan problem itu pandangan hidup Islam patut menjadi solusi. Pernikahan disebut dengan mitsaqan ghaliza dan merupakan sebuah sarana yang menghadirkan kenyamanan dan keserasian antara dua manusia. Dengan menggunakan pendekatan library research dan metode analisis konten. Penulis menemukan tiga problem konsep pernikahan menurut feminis, pertama pernikahahan memfasilitasi kekerasan terhadap perempuan, kedua hubungan suami istri tanpa persetujuan adalah pemerkosaan, ketiga child free wanita tidak bisa dipaksa untuk memiliki anak dan harus memiliki me time.

Keyword: Pernikahan, Feminisme, mitsaqan ghaliza
Implementation of The Al-Attas’s Islamization on The Impact of Desacralization of Politics
Authors: Pramono Muhamad Fajar , Sahidin Amir
Published: March 2024

Desacralization of politics is a thought born from a Western secular perspective, aiming to separate religion from politics. It has a bad influence on human life both in epistemologically and methodologically aspects. In addition, this thought also had an impact and was adopted by Muslim scholars, one of which was Ali Abdul Raziq in his secular political theory. Ali argues that "The message of the Prophet is purely a religious message", and "Political matters are only a matter of reason and human experimentation". As an effort to diagnose and treat the negative impact of desacralization of politics on these Muslim scholars, it is necessary to implement the Islamization of knowledge initiated by al-Attas. Through library research with a descriptive analysis approach, it can be concluded that, firstly, the Islamization of knowledge can be carried out in two steps, de-westernization and integration. Secondly, as a result of this Islamization, Ali Abdul Raziq's political thought which was originally secular can be Islamized into, "The message of the Messenger of Allah is a treatise that covers the affairs of the world and the hereafter" and "Political matters must be left to revelation, reason and human experimentation which do not conflict with revelation.
Groundwater rivals aridity in determining global photosynthesis
Authors: Giardina Francesco , Seneviratne Sonia I. , Liu Jiangong , Stocker Benjamin D. , Gentine Pierre
Published: March 2024

Understanding the role of groundwater in regulating photosynthesis is key in land-climate interactions. However, the impact of groundwater on terrestrial ecosystem productivity remains poorly understood. Here, we use satellite observations of solar-induced fluorescence as a proxy for photosynthesis, together with estimates of water table depth (WTD) and aridity as quantified by the annual moisture index with reanalysis data, to investigate the relationships between groundwater and photosynthesis. Using explainable machine learning (Shapley additive explanations or SHAP), we demonstrate that groundwater plays a crucial role in determining the spatial patterns of global photosynthesis, with varying importance across different ecosystem types, and that this effect is comparable to aridity. We show that in forests across the contiguous USA (CONUS), the relative importance of groundwater represents 89% of the effect attributed to the moisture index in modulating photosynthesis, and this impact is even more pronounced globally (105% relative importance). The relative importance of groundwater compared to the moisture index remains substantial in grasslands (37%), savannas and shrublands (25%), and croplands (15%) in CONUS. Global analysis confirms these trends for grasslands (41%) and croplands (15%) but indicates a 60% importance in savannas and shrublands. Our findings highlight the key global role of groundwater in driving ecosystem productivity.
Exploring Patterns in Online Discussions into the Lingering Impact of COVID-19, Two Years On
Authors: Sinha Gaurav R. , Power Shannon R. , Kursuncu Ugur
Published: March 2024

Purpose
The purpose of this study was to explore underlying patterns in the users’ discussions in an online community on the darker effects of COVID-19. Understanding these patterns is critical as they can provide new information in tailoring support to individuals facing specific post-pandemic issues.
Methods
A mixed-method approach was used to identify patterns in large volumes of publicly available responses (n = 23,957 posts; ~1,061,825 words) from an online community. Qualitatively, 1,000 random responses were manually coded by two coders and vetted by an investigator. As it was difficult to manually code such a big dataset, a quantitative approach building a topic model was employed with a language model.
Results
Qualitative analyses revealed 20 themes, including mental health (13%), impacts of direct and indirect deaths on socio-economically vulnerable groups (e.g. children and elderly, 10.4%), increasing sociopolitical divide and vaccination debate (6.8%), and work-related issues (e.g. burnout and layoffs, 6%). Topic analyses resulted in similar categories (n = 30), including physical health, loss experiences during COVID-19 & suicide; sociopolitical impact & adaptations in pandemic lifestyle; mental health & vaccination; pandemic restrictions, youth & behavioral expectations; distrust for institutions & resource scarcity; staffing issues & personal crisis; disrupted careers; and childcare challenges & economic shifts.
Conclusion
As researchers are harnessing vast amounts of real-time human interaction data to study a variety of public health issues, our study provides insights into the specific challenges that people experienced when it became convenient to share concerns online amid an overloaded healthcare system during the pandemic.
Machining Induced Damages in the Drilling of CFRP under Dry and Cryogenic Environments
Authors: Mathiyazhagan Vijayathithan , Meena Anil
Published: March 2024

Carbon Fiber-Reinforced Polymers (CFRP) present machining challenges due to inherent properties such as inhomogeneity and anisotropy, which make them vulnerable to damage during drilling. This study investigates the machining-induced damage caused by drilling CFRP composite laminates under dry and cryogenic conditions, considering the impact of cutting speeds, feed rates, and tool coatings on thrust force, delamination, and surface roughness. Acoustic Emission (AE) measurements are also performed to investigate machining-induced damage at different stages of the machining process. The experimental results show that machining-induced damage is significantly reduced under cryogenic conditions compared to dry drilling. Under cryogenic conditions, the combination of high feed rates and cutting speeds resulted in a 13.2% reduction in average delamination factor, a 10.5% improvement in surface roughness, and a 43.4% decrease in acoustic emission RMS compared to dry drilling. A scanning electron microscope (SEM) and a 3D surface profilometer are also used to assess machining-induced damage to the hole wall surface under dry and cryogenic conditions.
The Causal Relationship Between Blood Cell Indices and 28-Day Mortality in Sepsis: A Bidirectional Mendelian Randomization Analysis
Authors: Zeng Tao , Sun Yina , Chen Shuru , Pang Jiahui , Wang Heping , Cai Xianghao , Liao Yingying , Xiao Xiaolong , Zhang Yibo , Chong Yutian , Gong Jiao , Li Xinhua
Published: March 2024

Background: Despite emerging evidence linking blood cell indices (BCIs) to sepsis mortality, the inconsistency of observational studies obscures the clarity of these associations. This study aims to clarify the causal influence of BCIs on 28-day mortality rates in sepsis patients.
Methods Utilizing univariable and multivariable Mendelian randomization (MR) analyses, we examined the impact of BCIs on sepsis mortality by analyzing data from extensive genome-wide association studies. The inverse-variance weighted (IVW) method was our primary analytic tool, complemented by several robustness checks to mitigate pleiotropy, including weighted median, mode-based estimates, MR-Egger regression, and MR-PRESSO.
Results: Our findings highlight a significant causal relationship between platelet distribution width (PDW) and 28-day mortality in sepsis, with the univariable Mendelian randomization approach yielding an odds ratio of 1.12 (95% CI, 1.06-1.26; P < 0.05). Multivariable analysis further substantiated PDW’s robust association with mortality risk (OR 1.23; 95% CI, 1.03-1.48; P < 0.05). Conversely, our analysis did not uncover significant correlations between the genetic predispositions to other BCIs—including red blood cell count, erythrocyte distribution width, platelet count, mean platelet volume, white blood cell count, neutrophil count, neutrophil percentage, lymphocyte count, and lymphocyte percentage—and the 28-day mortality in sepsis. Additionally, an inverse MR analysis did not establish a causal impact of 28-day mortality in sepsis on PDW (OR 1.00; 95% CI, 1.00 to 1.07; P = 0.29).
Conclusions: The study underscores the independent causal role of PDW in predicting 28-day mortality in sepsis, suggesting its potential utility in early patient assessment, risk stratification, and tailoring of therapeutic intervention.
Development and validation of an Arabic questionnaire to assess dentist knowledge on managing deep caries cavities
Authors: Alghourani Rashad , Achour Hassan , Milly Hussam
Published: March 2024

Introduction:
The interconnection between oral health and systemic well-being is widely recognized, with dental caries being a prevalent global oral disease. This study focuses on the development and validation of a unique Arabic-language questionnaire to evaluate dentists' knowledge and skills in managing deep caries.
Aim
To create and validate the first Arabic questionnaire specifically for assessing dentists' competence in diagnosing and managing deep caries cavities.
Methods
The study adopted a multi-stage approach, including translation and adaptation of existing questionnaires, addition of new items by experts, and a thorough validation process. A balanced sample of 20 dentists from Damascus University Faculty of Dentistry participated. The questionnaire encompassed items divided into categories of diagnosis, treatment, and tools. Statistical analysis for internal and external validity, reliability, and other factors was conducted using SPSS.
Results
The questionnaire demonstrated high internal consistency (Cronbach's Alpha = 0.804, 0.879 for standardized items) and good test-retest reliability. Some items showed strong positive correlations, while a few indicated weaker correlations, revealing areas for potential refinement. The study highlighted significant correlations in most parameters, affirming the questionnaire's reliability.
Conclusion
This research successfully developed and validated the first Arabic-language questionnaire for assessing dentists' knowledge in managing deep caries cavities. The methodology ensured the tool's reliability and validity, with practical implications for dental education and practice in Arabic-speaking regions.
The Evolution of Trust and Its Influence on Organisational Citizenship Behaviour
Authors: Danish Fajer
Published: March 2024

This paper aims to explore the relationship between trust and organizational citizenship behavior (OCB) within the Bahrain Olympic Committee (BOC). Employing a qualitative research methodology, the study conducts in-depth semi-structured interviews with 17 BOC managers, focusing on five key themes of OCB: altruism, civic virtue, conscientiousness, courtesy, and sportsmanship. The findings reveal that increased levels of managerial trust positively impact all OCB themes, particularly civic virtue, which indicates a strong emotional commitment and support for BOC activities. These results suggest that enhancing trust can lead to greater employee engagement in behaviors beyond their formal work roles. The study makes significant contributions to the literature, especially in the Middle Eastern context, and offers practical recommendations for future research and practitioners in the field of trust.
Damage Mechanism Investigation on Fiber Reinforced Recycled Cement Aggregate Concrete in a Cold Region
Authors: LI WEI , LI ZHENG , XU WENYUAN , JI YONGCHENG
Published: March 2024

In order to investigate the internal damage mechanism of carbon fiber-reinforced recycled concrete, microscopic, mechanical, and freeze-thaw cycle experimental programs were conducted. Three categories of recycled concrete specimens with different recycled concrete admixtures and reinforcement modes were designed in this study. Axial compression tests and freeze-thaw cycles were conducted, combined with SEM and fracture surface observation and analysis, which were used to study the effects of the ratio of carbon fiber reinforcement and admixture of recycled aggregates on the mechanical properties of the concrete, the freezing resistance, and the microstructure. Research results indicate that carbon fiber reinforcement can effectively improve recycled concrete's strength and frost resistance. The increase in reinforcement ratio gradually increased mechanical strength and frost resistance. Compared with the unreinforced concrete, the axial strength of semi-reinforced and fully reinforced specimens was enhanced by 25% and 42.5%, respectively. The 100% recycled substitution rate specimens were treated with full reinforcement. Their compressive strengths were similar to those of unreinforced natural aggregate concrete. The compressive strength of the fully reinforced specimens was similar to that of the unreinforced natural aggregate concrete. Furthermore, the mechanism of strength loss in recycled concrete is obtained through microstructural analysis. A uniaxial compression numerical model of CFRP-reinforced recycled concrete was established, and a modified CFRP-reinforced cement-recycled concrete was proposed to accurately determine the ontological relationship for different reinforcement ratios and recycled aggregate admixtures. A BP neural network model was developed by MATLAB to effectively predict the compressive strength of recycled concrete with different mix ratios under different numbers of freeze-thaw cycles.
Tri-reforming of methane over Ni/ZrO2 catalyst derived from Zr-MOF for the production of synthesis gas
Authors: Pandey Akansha , Biswas Prakash
Published: March 2024

Tri-reforming of methane (TRM) is a promising route for using greenhouse gases such as CH4 and CO2 to produce synthesis gas with the H2/CO ratio of 1.5-2. In this study, a series of Zr-MOF synthesized via the solvothermal method, and impregnation technique was used to synthesize the nickel impregnated on MOF derived ZrO2 catalyst. The catalyst was characterized by various methods, including N2 adsorption-desorption, X-ray diffraction, TPR, CO2-TPD, TGA, Chemisorption, FE-SEM, HR-TEM etc. Characterization results confirmed the formation of the Zr-MOF and nickel metal dispersed on MOF derived ZrO2. Further, the tri-reforming activity of the catalyst developed was evaluated in a downflow packed bed reactor. The various catalysts were screened for their TRM activity at different temperatures (600-850 oC). Results demonstrated that TRM was highly favorable over the NZ-1000 catalyst due to its desirable physicochemical properties, including nickel metal surface area (2.3 m2/gcat-1), metal dispersion (7.1%), and nickel metal reducibility (45%), respectively. Over NZ-1000 catalyst and optimum H2/CO ratio of ~1.6-2 was achieved at 750 °C, and it was stable for longer period of Time.
Improvement in Depressive Symptoms in a Patient with Severe and Enduring Anorexia Nervosa and Comorbid Major Depressive Disorder Using Psychotherapy-Assisted IV Ketamine : A Case Report
Authors: Timek Amanda , Daniels-Brady Catherine , Ferrando Stephen
Published: March 2024

Background :
Anorexia nervosa is a life-threatening psychiatric illness with a high mortality rate and limited treatment options. This illness is frequently comorbid with major depressive disorder, leading to additional obstaces in patient quality of life, and increasing the mortality rate further due to risk of suicide. Ketamine, an competitive N-methyl-D-aspartate receptor antagonist, has been shown to be beneficial in depression given its effects on neuroplasticity. There are few cases in the literature describing ketamine use in patients with eating disorders, and even fewer that describe psychotherapy-assisted ketamine use in this patient population. We present the case of a 33-year-old woman with a history of severe and enduring anorexia nervosa and comorbid major depressive disorder who we treated safely with ketamine-assisted psychotherapy using intravenous ketamine in a general hospital setting.
Case presentation :
Our patient is a 33-year-old woman with past psychiatric history of severe and enduring anorexia nervosa and major depressive disorder with comorbid psychiatric and medical conditions who presented to the hospital due to malnutrition. She had an extensive psychiatric history as well as multiple medical hospitalizations due to her eating disorder. She had tried numerous psychiatric treatments, including antidepressants, mood stabilizers, antipsychotics, electroconvulsive therapy, and multiple types of therapies without significant improvement in symptoms. She agreed to try ketamine for treatment-resistant depression and received it intravenously for seven sessions in a closely monitored setting, and simultaneously engaged in acceptance and commitment therapy during sessions. She demonstrated increased cognitive flexibility, disappearance of suicidal ideation, and reduction in Beck Depression Inventory Scores.
Conclusions :
Our case in unique in that it demonstrates the successful usage of ketamine-assisted psychotherapy in a hospital setting with severe and enduring anorexia nervosa and comorbid major depressive disorder. Her body mass index was profoundly low at 13, whereas the lowest documented in the literature was 16.9. This case shows that ketamine-assisted psychotherapy may be a promising treatment modality for patients with anorexia nervosa with co-morbid depression who have failed other interventions.
L-carnitine Prevents Colistin-induced Mitochondrial Permeability Transition and Reduces the Risk of Acute Kidney Injury in Mice
Authors: Samodelov Sophia , Gai Zhibo , De Luca Francesca , Haldimann Klara , Hobbie Sven , müller Daniel , Kullak-Ublick Gerd , Visentin Michele
Published: March 2024

Colistin is a polymyxin antibiotic currently experiencing renewed clinical interest due to its efficacy in the treatment of multidrug resistant (MDR) bacterial infections. The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment. The mechanism of colistin-induced renal toxicity has been postulated to stem from mitochondrial damage, yet there is no direct evidence of colistin acting as a mitochondrial toxin. The aim of this study was to evaluate whether colistin can directly induce mitochondrial toxicity and, if so, uncover the underlying molecular mechanism. We found that colistin leads to a rapid permeability transition of mitochondria isolated from mouse kidney that was fully prevented by co-incubation of the mitochondria with desensitizers of the mitochondrial transition pore cyclosporin A or L-carnitine. The protective effect of L-carnitine was confirmed in experiments in primary cultured mouse proximal tubular cells. Consistently, the risk of colistin-induced kidney damage, assessed by histological analysis as well as by the early marker of tubular kidney injury, Kim-1, was halved under co-administration with L-carnitine in vivo. Notably, L-carnitine neither affected the pharmacokinetics of colistin nor its antimicrobial activity against relevant bacterial strains. In conclusion, colistin targets the mitochondria and induces permeability transition thereof. L-carnitine prevents colistin-induced permeability transition in vitro. Moreover, L-carnitine co-administration confers partial nephroprotection in mice treated with colistin, without interfering with its pharmacokinetics and antibacterial activity.
The Majority of SARS-CoV-2 Plasma Cells are Excluded from the Bone Marrow Long-Lived Compartment 33 Months after mRNA Vaccination
Authors: Lee Frances , Nguyen Doan , Hentenaar Ian , Morrison-Porter Andrea , Solano David , Haddad Natalie , Castrillon Carlos , Lamothe Pedro , Andrews Joel , Roberts Danielle , Lonial Sagar , Sanz Ignacio
Published: March 2024

The goal of any vaccine is to induce long-lived plasma cells (LLPC) to provide life-long protection. Natural infection by influenza, measles, or mumps viruses generates bone marrow (BM) LLPC similar to tetanus vaccination which affords safeguards for decades. Although the SARS-CoV-2 mRNA vaccines protect from severe disease, the serologic half-life is short-lived even though SARS-CoV-2-specific plasma cells can be found in the BM. To better understand this paradox, we enrolled 19 healthy adults at 1.5-33 months after SARS-CoV-2 mRNA vaccine and measured influenza-, tetanus-, or SARS-CoV-2-specific antibody secreting cells (ASC) in LLPC (CD19-) and non-LLPC (CD19+) subsets within the BM. All individuals had IgG ASC specific for influenza, tetanus, and SARS-CoV-2 in at least one BM ASC compartment. However, only influenza- and tetanus-specific ASC were readily detected in the LLPC whereas SARS-CoV-2 specificities were mostly excluded. The ratios of non-LLPC:LLPC for influenza, tetanus, and SARS-CoV-2 were 0.61, 0.44, and 29.07, respectively. Even in five patients with known PCR-proven history of infection and vaccination, SARS-CoV-2-specific ASC were mostly excluded from the LLPC. These specificities were further validated by using multiplex bead binding assays of secreted antibodies in the supernatants of cultured ASC. Similarly, the IgG ratios of non-LLPC:LLPC for influenza, tetanus, and SARS-CoV-2 were 0.66, 0.44, and 23.26, respectively. In all, our studies demonstrate that rapid waning of serum antibodies is accounted for by the inability of mRNA vaccines to induce BM LLPC.
Cancer-associated fibroblasts-derived exosomal piR-35462 promotes the progression of oral squamous cell carcinoma via FTO/Twist1 pathway
Authors: Ye Yushan , Wu Fan , Li Bowen , Ma Hanyu , Mai Lianxi , Peng Yu , Feng Xiaodi , Tan Xiao , Fu Min , Tan Yongmei , Lan Tianjun , Wang Ruixin , Ren Siqi , Li Jinsong , Chang Shaohai , Xie Shule
Published: March 2024

Background: Cancer-associated fibroblasts (CAFs) play a critical role in tumor progression. In this study, we explored the influence of exosomal piR-35462 (piR-35462) derived from CAFs on oral squamous cell carcinoma (OSCC) progression.
Methods: CAFs and normal fibroblasts (NFs) were obtained from patients-derived samples of OSCC and adjacent normal tissues. Exosomes extracted from CAFs and NFs were confirmed and piRNAs was identified screened. CCK8 assays, EdU and Transwell assays were performed to assess tumor proliferation and metastasis. A nude mouse model was established to assess the impact of exosomal piR-35462 on tumor progression.
Results: CAFs-derived exosomes showed a enhanced piR-35462 expression and promoted OSCC cell proliferation, migration and invasion. Additionally, elevated piR-35462 expression in OSCC tissues correlates with poor prognosis. Mechanistically, CAFs-derived exosomal piR-35462 increased the expression of fat mass and obesity-associated protein (FTO) in OSCC cells. By inhibiting N6-methyladenosine (m6A) RNA methylation, the overexpression of FTO further enhances the stability and expression levels of Twist1 mRNA, thereby contributing to epithelial-mesenchymal transition (EMT) and tumor progression. In vivo xenograft tumor model also confirmed the same results.
Conclusion: The achieved outcomes elucidate that CAFs can deliver piR-35462 containing exosomes to OSCC cells and promote OSCC progression via FTO/Twist mediated EMT pathways, and could represent a promising therapeutic target for OSCC.
A machine learning based on CT radiomics signature and change value features for predicting the risk classification of thymoma
Authors: zhu Liang , Li Jiaming , Tang Yihan , Zhang Yaxuan , Chen Chunyuan , Li Siyuan , Wang Xuefeng , Zhuang Ziye , He Shuyan , deng biao
Published: March 2024

Objective:
The aim of this study is to propose a medical imaging and comprehensive stacking learning based method for predicting high and low risk categories of thymoma.
Methods:
This retrospective study collected 126 patients with thymoma and 5 patients with thymic carcinoma treated at our institution, including 65 low-risk cases and 66 high-risk cases. Among them 78 cases were the training cohort. The rest formed the validation cohort (53 cases). Radiomicsfeatures and variation features are extracted from collected medical imaging data. Mann-Whitney U-test was used to identify and determine potential differences between categories and features with p<0.05 were retained. Feature selection was first performed using LASSO regression, and then the top ten features with the highest potential for differentiation were selected using the SelectKBest method. By applying stacked ensemble learning, we combine three machine learning algorithms to provide an efficient and reliable solution for risk prediction of thymoma.
Results:
A total of 54 features were identified as the most discriminative features for low-risk and high-risk thymoma, and were used to develop radiomics features. Our model successfully identified patients with low-risk and high-risk thymoma. For the imaging omics model, the AUC in the training and validation cohorts were 0.999 (95%CI,0.988-1.000) and 0.967(95%CI,0.916-1.000). For the nomogram, the values were 0.999 (95%CI,0.996-1.000) and 0.983 (95%CI,0.990-1.000).
Conclusion:
This study describes the application of CT based radiomics in thymoma patients and proposes a clinical decision nomogram that can be used to predict the risk of thymoma. This nomogram is advantageous for clinical decision-making concerning thymoma patients.
The colonization of soil microorganism affected the growth and the accumulation of secondary metabolites of Bletilla striata (Thunb.) Rchb. F
Authors: Xu Qingqing , Fu Yan , Zhang Jinqiang , Xu Chunyun , Yang Changgui , Yuan Qingsong , Xu Jiao , Jiang Weike , Zhang Yongping , Zhou Tao , Xiao Chenghong
Published: March 2024

Bletilla striata (Thunb.) Rchb. F., a perennial herbaceous plant known for its medicinal properties. The growth and secondary metabolite production of B. striata can be influenced by soil microorganisms. To investigate the soil microbes that enhance B. striata growth and quality, we planted B. striata sterile seedlings in radiation-sterilized soil amended with microbiota from sandy clay or sandy loam soils. After two years of growth, we conducted 16S and ITS Illumina sequencing to identify bacteria and fungi colonizing B. striata rhizosphere soil, roots, tubers, and leaves. We determined the growth indices of the B. striata, simultaneously, we used UHPLC-MS/MS to determine metabolites in B. striata tubers, finally, we quantified the index component militarine in B. striata, we found significant differences in B. striata metabolites among different soil microbial treatments, with sandy loam microorganisms promoting the growth of B. striata, while sandy clay microorganisms increased the content of secondary metabolites. We identified specific microbes predominantly in loam soil that colonized roots and promoted growth (e.g., Entrophospora, Aspergillus, Fusarium). Similarly, certain microbes in loam soil colonized tubers and enhanced their growth (e.g., Sphingomonas, Hyphomicrobium). Additionally, microbes predominantly found in sandy soil colonized tubers and stimulated the synthesis of secondary metabolites (e.g., Myrmecridium, Apiotrichum montevideense). The Aspergillus versicolor (B-6) isolated from the B. striata rhizosphere soil after transplantation of sandy loam microorganisms, after inoculation with B-6 with B. striata sterile seedlings, it was found that B-6 could promote B. striata sterile seedlings growth. Our analysis uncovers that the soil microorganisms can colonize various regions of B. striata, thereby influencing its growth and secondary metabolite production. These findings hold implications for enhancing the yield and quality of B. striata in both medicinal and agricultural contexts.
Treatment Strategy for Compartment Syndrome at Multiple Regions due to Injuries Caused by a Tree Fall: A Case Report
Authors: Miura Tomotaka , Miyake Takahito , Okada Hideshi , Oiwa Hideaki , Mizuno Yosuke , Kitagawa Yuichiro , Fukuta Tetsuya , Okamoto Haruka , Shiba Masato , Kanda Norihide , Yoshida Takahiro , Yoshida Shozo , Ogura Shinji
Published: March 2024

Background
Compartment syndrome commonly occurs in patients with forearm and lower leg fractures. Compartment syndromes of the gluteal and thigh muscles are less common. It is imperative that compartment syndrome be diagnosed and treated with fasciotomy as soon as possible. However, there are few reports on the diagnosis and treatment strategies for compartment syndromes that occur simultaneously in multiple anatomical regions or in the ipsilateral gluteal region and thigh.
Case presentation:
We report on a 76-year-old man who was obliquely crushed under a tree extending from the right forearm to the left groin. He was brought to our emergency room, where he was diagnosed with compartment syndrome of the right forearm and left lower leg, and crush syndrome. Emergency fasciotomy was performed. On the day after admission, swelling and tightness of the left gluteal thigh became apparent, and intracompartmental pressures were elevated, which led to an additional diagnosis of these compartment syndromes. A fasciotomy was performed, the gluteal skin incision was made according to the Kocher-Langenbeck approach (one of the posterior approaches for hip fractures), and the thigh was approached by extending the incision laterally. This surgical approach enabled the decompression of the compartments through a single incision and allowed for easier wound treatment and closure.
Conclusion
This case highlights the diagnosis and treatment of compartment syndrome in four anatomical regions. Extension of the Kocher-Langenbeck approach to the lateral thigh can be a useful surgical approach for ipsilateral gluteal and thigh compartment syndrome.