bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Inhibitory Effects of Blebbistatin on Actomyosin Interactions in Myofibrils and Isolated Myofilaments
Authors: Elkrief Daren , Cheng Yu-Shu , Rassier Dilson E.
Published: February 2025

Myosin II is the molecular motor responsible for muscle contraction. Myosin II hydrolyses ATP into Piand ADP, to convert chemical energy into mechanical work while attached to actin filaments. The relation between force generation and Pirelease remains unclear. Many studies use chemical substances, such as blebbistatin, to study the transitions during actomyosin interactions. Blebbistatin and its derivatives selectively inhibit the actin-activated ATPase of myosin II, accumulating myosin cross-bridges in a pre-power-stroke state. Although the effects of blebbistatin have been explored, it is still unclear how blebbistatin affects force generation and the velocity of contraction. In this study, we used individual myofibrils, myosin and actin filaments, and isolated heavy meromyosin (HMM) and actin filaments to characterize the effects of blebbistatin. We observed that increasing concentrations of blebbistatin (i) decreased the force produced by myofibrils and isolated myosin filaments, (ii) decreased the maximum velocity of shortening produced by myofibrils and the myosin-induced actin sliding velocity, (iii) decreased the curvature of the force-velocity relation in a dose-dependent manner. Furthermore, UV radiation reduced the effect of blebbistatin, which was partially reversed if blebbistatin was bound to myosin before exposure to UV light. These results show that blebbistatin alters force and velocity generation at the molecular, myofilamentous and myofibrillar levels. This study has interesting implications in fields which rely on using blebbistatin to study cellular processes and confirms several results published in different experimental arrangements. Thus, this study is exploratory and confirmatory, and the findings have utility surrounding cell migration, muscle biophysics, cellular reproduction, or any processes that rely on the action of myosin II.
LAVR-289, a new acyclo-nucleoside phosphonate having broad-spectrum activity against herpesviruses
Authors: Kappler-Gratias Sandrine , Quentin-Froignant Charlotte , Marcheteau Elie , Fernandez José , Boutolleau David , Garcia Virginie , Roy Vincent , Agrofoglio Luigi A. , Gallardo Franck
Published: February 2025

Human herpesviruses are latent opportunistic large dsDNA viruses that can have deleterious effect in immunocompromised patients by triggering life-threatening infections. Over the past years, different antivirals have been developed against a variety of herpesviruses, including Acyclovir for herpes simplex viruses (HSV1 and 2) and ganciclovir and letermovir for human cytomegalovirus (hCMV). However, broad-spectrum inhibitors of herpesvirus infections are still missing. Here we report the efficacy of LAVR-289, a new acyclic nucleoside analog, on a broad variety of herpesviruses from human and animal origin. LAVR-289 displays nanomolar efficiencyin vitro, is active on viral strains resistant to gold standard antivirals andex vivoon reconstituted human skin infected with HSV1. Combined with its anti-poxvirus and anti-adenovirus activity, LAVR-289 can become the next gold standard for the management of opportunistic virus infections in immunocompromised patient.
The critical role of enterovirus 2A protease in viral translation, replication, and antagonism of host antiviral responses
Authors: Schipper Jelle G. , Aloise Chiara , Sutter Sereina O. , Zwaagstra Marleen , van Vliet Arno L.W. , Abdelnabi Rana , Ignacio Bob , Bonger Kimberly M. , Roelofs Dagmar , van den Brand Judith M.A. , Wubbolts Richard W. , Bruurs Lucas J.M. , Thibaut Hendrik Jan , Neyts Johan , Tanenbaum Marvin E. , van Kuppeveld Frank J.M.
Published: February 2025

Enteroviruses dramatically remodel the cellular infrastructure for efficient replication and curtailing host antiviral responses. Proteases 2Aproand 3Cprohave been implicated in these processes based onin vitrostudies, ectopic overexpression, and surrogate infection systems, but their relative contributions are unknown. Here, we replace the essential 2A cleavage site at the P1-P2 junction with an internal ribosome entry site (IRES), 3CD cleavage site, or T2A sequence, allowing us to catalytically inactivate 2Apro. Viruses with an inactive 2Aproare hampered in replication in cell lines and are severely attenuated in a Coxsackievirus B3 (CVB3) mouse pancreatitis infection model. We show that 2Apro, but not 3Cpro, is essential during infection for disturbing nucleocytoplasmic transport, shutting down host mRNA translation, suppressing stress granule formation, cleaving retinoic acid-inducible gene-1 (RIG-I)-like receptor (RLR) signaling pathway proteins and suppressing interferon-α/β (IFN-α/β) transcription, and overcoming the antiviral action of IFN-induced restriction factors. Moreover, using an advanced single-molecule live cell imaging approach, we reveal that 2Aprois important for the initial round of replication of the incoming viral RNA, which is a bottleneck for efficient infection. In conclusion, we establish that 2Aproplays a critical role in subverting antiviral responses and establishing a favorable host environment to expedite enterovirus replication.
Relativistic dips in entangling power of gravity
Authors: Toroš Marko , Schut Martine , Andriolo Patrick , Bose Sougato , Mazumdar Anupam
Published: February 2025

The salient feature of both classical and quantum gravity is its universal and attractive character. However, less is known about the behavior and build-up of quantum correlations when quantum systems interact via graviton exchange. In this work, we show that quantum correlations can remain strongly suppressed for certain choices of parameters even when considering two adjacent quantum systems in delocalized states. Using the framework of linearized quantum gravity with post-Newtonian contributions, we find that there are special values of delocalization where gravitationally induced entanglement drops to negligible values, albeit nonvanishing. We find a pronounced cancellation point far from the Planck scale, where the system tends toward classicalization. In addition, we show that quantum correlations begin to reemerge for large and tiny delocalizations due to Heisenberg’s uncertainty principle and the universal coupling of gravity to the energy-momentum tensor, forming a valley of gravitational entanglement.

Published by the American Physical Society
2025
Determining project control system effectiveness in construction project delivery
Authors: Alotaibi Rashed , Sohail M. , Edum-Fotwe F.T. , Soetanto Robby
Published: February 2025

Purpose

Many construction projects exhibit poor performance in terms of fulfilling predetermined schedules and financial objectives. Project control systems (PCSs) have been used to enhance construction project performance; however, a comprehensive framework regarding the key determinants of PCS effectiveness is lacking.

Design/methodology/approach

Herein, the determinants for effective PCSs that can improve construction project performance were comprehensively identified by evaluating existing studies. A systematic strategy following the preferred reporting items for systematic reviews and meta-analyses protocol was employed to search for and select relevant studies, followed by a qualitative synthesis.

Findings

The significance of incorporating and managing many factors associated with PCS for effective project delivery was elucidated. The study synthesized 12 key determinants and 29 sub-determinants of PCS effectiveness in project delivery and grouped them into organizational, human, technological and operational categories. Out of the four categories examined, operational aspects received the most references, underscoring their critical role in PCS effectiveness, while human-related dimensions received the least amount of attention in the reviewed research, accounting for 4%. This also revealed a significant gap in the research addressing the interactions between all PCS aspects.

Originality/value

Understanding of the variables influencing PCS effectiveness in construction project delivery was enhanced, and a framework for future PCS research in five dominant areas was created.
Enhancing ESG integration in corporate strategy: a bibliometric study and content analysis
Authors: Almnadheh Yazan , Samara Husni , AlQudah Mohammad Zakaria
Published: February 2025

Purpose

This study aims to develop a comprehensive framework for environmental, social and governance (ESG) integration in corporate strategy by differentiating between four mechanisms: legality, ethical concerns, monitoring and motivation. These mechanisms are examined from governance and performance perspectives to provide a deeper understanding of their implications.

Design/methodology/approach

A systematic review of the Web of Science database formed the basis of this study. Descriptive analyses tracked publication trends, while detailed content analysis identified key themes. These findings were synthesized into a conceptual framework for ESG integration, ensuring practical relevance for scholars and practitioners.

Findings

The study identifies areas where ESG integration influences corporate strategy, such as enhanced corporate governance, ethical decision-making, risk management and improved organizational performance. Notable trends include the increasing emphasis on regulatory compliance and ethical concerns in corporate governance, reflecting shifts in priorities across academic and industry domains. The framework provides a foundation for advancing research and strategic ESG implementation.

Practical implications

The findings offer actionable insights for corporate strategists and policymakers to enhance risk management, operational efficiency and corporate reputation through ESG adoption.

Social implications

Enhanced ESG integration fosters social equity and sustainable development by promoting ethical practices and addressing stakeholder concern.

Originality/value

This research introduces a novel framework that categorizes drivers and consequences of ESG adoption, bridging gaps in the literature.
Innovators and Transformers: Enhancing supply chain sustainability: a methodology combining dynamic simulation and case studies
Authors: Negri Pietro
Published: February 2025

Purpose

This paper scrutinizes existing assessment methodologies in supply chain sustainability literature and identifies a gap in microeconomic methods for comprehensively estimating current and prospective supply chain performances, encompassing both financial and environmental aspects. It presents a case study where quantitative, dynamic simulation modeling is applied to articulate and amplify a company’s sustainability performance, demonstrating that a holistic approach to performance metrics can significantly refine decision-making and action prioritization in sustainability.

Design/methodology/approach

Introduced here is the “ISSSC Approach, ” which employs dynamic simulation modeling to quantify the flux of materials, value, and emissions within a supply chain. This methodology facilitates the construction of representative models and subsequent scenarios to inform sustainable decision-making that aligns with business objectives. The utility of the ISSSC Approach is evidenced through a case study within the dairy industry.

Findings

The case study offers three pivotal insights: the innovation of a fact-based sustainability framework over traditional anecdotal methods, the harmonization of competitive and sustainable performance indicators within a company’s strategic ambit, and the presentation of a novel tool for precise sustainability measurement and enhancement, attuned to context-specific constraints.

Originality/value

While dynamic simulation modeling is well-established, its application to sustainability in a manufacturing context is markedly innovative. The ISSSC Approach bridges the gap between regulatory directives and the realization of tangible benefits for all stakeholders, positioning it as a critical tool for operationalizing sustainability in corporate strategy.
Understanding user behaviors toward food delivery app services: the moderating effects of generation and usage frequency
Authors: Alam Mirza Mohammad Didarul , Hussain Khalid , Nusair Khaldoon , Momotaz Shamsun Nahar
Published: February 2025

Purpose

This paper investigates the influence of e-service quality (process and user experience) and price fairness on customer satisfaction, which, as a consequence, affects brand love toward Food Delivery App (FDA) services. More importantly, it examines the moderating roles of generation (Gen Y vs Gen Z) and usage frequency (low vs high) in affecting user behaviors.

Design/methodology/approach

Data were collected from 354 food delivery app users (Gen Y and Z) in Bangladesh through structured questionnaire and analyzed with PLS-SEM.

Findings

The findings show that, apart from reliability, all the dimensions of service quality influence app users’ satisfaction, which, in turn, enhances their brand love. Furthermore, the outcome reveals that the impact of customer satisfaction on brand love is stronger among Gen Y compared to Gen Z. Finally, the outcomes suggest that as users use the FDA services more frequently, the relationship between customer satisfaction and brand love weakens.

Practical implications

The study outcomes facilitate the FDA service providers and restaurant operators to focus on the quality and price of services to ensure the satisfaction and brand love of Gen Y and Gen Z. Separate policies must be taken for Gen Y and Gen Z to manage their brand love towards FDA services.

Originality/value

Grounded on the S-O-R paradigm and the Generational Cohort theory, this study expands the knowledge horizon of FDA services by focusing the behavior of Gen Y and Gen Z. More specifically, investigating how the impact of user satisfaction on brand love towards FDA services changes across generations and usage frequency are the novel contributions of this study.
Open strategizing by public organizations: a qualitative comparative analysis of recent practices in Dutch infrastructure planning
Authors: Baartmans Manon Danielle , Busscher Tim , Verweij Stefan , Arts Jos
Published: February 2025

Purpose

Wide participation in the strategic processes of public organizations can enhance inclusion and transparency, thereby contributing to improved performance of public organizations. However, engaging with external participants is easier said than done. This study aims to identify how public organizations can open up their strategic processes to external participants.

Design/methodology/approach

The analysis is based on qualitative data from 12 early-phase strategy projects in the 2023 Dutch Multi-Year Program for Infrastructure, Spatial Planning and Transport (MIRT). Interviews and document data were collected and analyzed using qualitative comparative analysis (QCA).

Findings

This study identifies that the government steering the process itself, by aiming for idea generation, opens up strategic processes. This is necessary for contributing to improved public service performance.

Practical implications

This study provides strategy actors (e.g. managers, planners and consultants) with actionable knowledge about what open strategizing with external participants requires to create openness.

Originality/value

This study addresses the ongoing and increased interest in the openness of strategy processes in general and in infrastructure planning in particular. It contributes to the discussion on whether and how participation leads to improved performance of public organizations. Additionally, this study illustrates the application of QCA to the study of open strategy processes.
Technological acceptance in the retail sector: an empirical generalisation by a meta-analytic study
Authors: Santini Fernando de Oliveira , Maçada Antonio Carlos Gastaud , Freitas Junior José Carlos , Ladeira Wagner Junior , Oliveira Tiago
Published: February 2025

Purpose

The purpose of this study is to present a systematic analysis using a meta-analytical approach regarding the antecedents and consequences of the technology acceptance model (TAM) in the retail context. This paper also analysed five different theoretical models using meta-analytic structural equation modelling. Finally, this paper investigated possible moderators on the relationships between TAM constructs.

Design/methodology/approach

This manuscript is conceptual as it is based on a literature review. In this line, this paper analysed 85 articles by a meta-analysis that generated 431 effect sizes and identified 8 antecedents and 2 consequences of the TAM construct.

Findings

All antecedents and consequences promoted significant effect sizes with TAM constructs. In the moderation analysis, this paper determined that top journals and countries with a high human development index promoted more substantial effect sizes in the relationship between perceived usefulness (PU) and behavioural intention, and PU and attitude towards system use, respectively. About the theoretical models tested, this paper found that the antecedents enjoyment and trust represent the best fit in TAM models, which affects attitude and behavioural intentions.

Originality/value

This research tested the impact of TAM’s antecedents, consequences and moderators in the retail sector and presented important results via a meta-analytical review. This meta-analysis contributes to the marketing literature by offering a set of empirical generalisations, including relationship coefficients and calculated fail-safe numbers.
The Dunning–Kruger effect and artificial intelligence: knowledge, self-efficacy and acceptance
Authors: Guan Jian , He Xiao , Su Yuhan , Zhang Xin-an
Published: February 2025

Purpose

Artificial Intelligence (AI) is revolutionizing the world. Despite the numerous advantages of AI in terms of faster processing and higher efficiency, AI hasn’t been widely accepted by humans yet. This study aims to shed light on this phenomenon by exploring the Dunning–Kruger Effect in AI knowledge and examining how AI knowledge affects AI acceptance through AI-related self-efficacy.

Design/methodology/approach

By collecting data from 179 managers, we examined the Dunning–Kruger Effect in AI knowledge and used mediation analysis to explore the mechanisms by which AI knowledge leads to AI acceptance.

Findings

Our findings indicated the presence of the Dunning–Kruger Effect in AI knowledge. Furthermore, our results revealed that AI knowledge has a nonlinear effect on AI acceptance through AI-related self-efficacy.

Originality/value

In contrast to previous research that posited a linear link between knowledge and acceptance of technology, this study offers a new framework for the nonlinear relationships between AI knowledge, AI-related self-efficacy and AI acceptance by extending the Dunning–Kruger effect to the AI field.
Does humanizing the police improve the effectiveness of police recruiting efforts?
Authors: Hill Shawn L. , Brimbal Laure , Maguire Edward R. , Stephens Eve
Published: February 2025

Research Summary

U.S. police agencies are currently facing a serious recruiting and staffing crisis. As a result, many scholars and police leaders are re‐examining police recruiting methods. This study draws on the field of intergroup communication to examine the effects of how police are portrayed in police recruitment materials. Using a randomized survey experiment, we tested the effects of humanizing how officers are portrayed in a recruiting video relative to a more traditional, action‐oriented portrayal. We showed police recruiting videos to a sample of 325 university students. Within the videos, we varied how a female police officer described her career and her personal life. We then measured the extent to which the treatment influenced participants’ general attitudes toward police and specific attitudes toward working in policing. The treatment had significant effects on the two general attitudinal outcomes (shared identity and institutional trust), but did not have a significant direct effect on respondents’ interest in working in policing. Notably, the treatment had significant indirect effects on respondents’ interest in a career in policing via shared identity, but not via institutional trust.

Policy Implications

Applying principles from the study of intergroup communication can help police agencies develop recruiting materials that humanize the police and promote a shared identity with police officers, thereby attracting a larger and more potentially diverse pool of candidates.
An Initial Genome Editing Toolset for Caldimonas thermodepolymerans, the First Model of Thermophilic Polyhydroxyalkanoates Producer
Authors: Grybchuk‐Ieremenko Anastasiia , Lipovská Kristýna , Kouřilová Xenie , Obruča Stanislav , Dvořák Pavel
Published: February 2025

The limited number of well‐characterised model bacteria cannot address all the challenges in a circular bioeconomy. Therefore, there is a growing demand for new production strains with enhanced resistance to extreme conditions, versatile metabolic capabilities and the ability to utilise cost‐effective renewable resources while efficiently generating attractive biobased products. Particular thermophilic microorganisms fulfil these requirements. Non‐virulent Gram‐negative Caldimonas thermodepolymerans DSM15344 is one such attractive thermophile that efficiently converts a spectrum of plant biomass sugars into high quantities of polyhydroxyalkanoates (PHA)—a fully biodegradable substitutes for synthetic plastics. However, to enhance its biotechnological potential, the bacterium needs to be ‘domesticated’. In this study, we established effective homologous recombination and transposon‐based genome editing systems for C. thermodepolymerans. By optimising the electroporation protocol and refining counterselection methods, we achieved significant improvements in genetic manipulation and constructed the AI01 chassis strain with improved transformation efficiency and a ΔphaC mutant that will be used to study the importance of PHA synthesis in Caldimonas. The advances described herein highlight the need for tailored approaches when working with thermophilic bacteria and provide a springboard for further genetic and metabolic engineering of C. thermodepolymerans, which can be considered the first model of thermophilic PHA producer.
Parallels and discrepancies between non‐native species introductions and human migration
Authors: Ahmed Danish A. , Sousa Ronaldo , Bortolus Alejandro , Aldemir Ceray , Angeli Nicole F. , Błońska Dagmara , Briski Elizabeta , Britton J. Robert , Cano‐Barbacil Carlos , Clark‐Ginsberg Aaron , Culic Irina , Cuthbert Ross N. , Dick Jaimie , Dimarco Romina D. , Essl Franz , Everts Teun , García‐Berthou Emili , Hauer Mathew , Kouba Antonín , Kourantidou Melina , Kutschera Ulrich , Mammola Stefano , Martín‐Forés Irene , Morissette Olivier , Nuñez Martin A. , Olden Julian D. , Pârvulescu Lucian , Pergl Jan , Renault David , Rico‐Sánchez Axel Eduardo , Russell James C. , Soto Ismael , Serhan Tarkan Ali , Uysal Tuğba Uçma , Verreycken Hugo , Vilizzi Lorenzo , Wasserman Ryan , Wehi Priscilla , Haubrock Phillip J.
Published: February 2025

Biological invasions and human migrations have increased globally due to socio‐economic drivers and environmental factors that have enhanced cultural, economic, and geographic connectivity. Both processes involve the movement, establishment, and spread of species, yet unfold within fundamentally different philosophical, social and biological contexts. Hence, studying biological invasions (invasion science) and human migration (migration studies) presents complex parallels that are potentially fruitful to explore. Here, we examined nuanced parallels and differences between these two phenomena, integrating historical, socio‐political, and ethical perspectives. Our review underscores the need for context‐specific approaches in policymaking and governance to address effectively the challenges and opportunities of human migration and harm from biological invasions. We suggest that approaches to studying the drivers of biological invasions and human migration provide an excellent opportunity for transdisciplinary research; one that acknowledges the complexities and potential insights from both fields of study. Ultimately, integrating natural and social sciences offers a promising avenue for enriching the understanding of invasion biology and migration dynamics while pursuing just, equitable, and sustainable solutions. However, while human migration is a clear driver of biological invasions, drawing on principles from biological invasions to understand past and current human migration risks oversimplification and the potential for harmful generalisations that disregard the intrinsic rights and cultural dynamics of human migrations. By doing so, we provide insights and frameworks to support the development of context‐specific policies that respect human dignity, foster cultural diversity, and address migration challenges in ways that promote global cooperation and justice. This interdisciplinary approach highlights the potential for transdisciplinary research that acknowledges complexities in both fields, ultimately enriching our understanding of invasion biology and migration dynamics while pursuing equitable and sustainable solutions.
European expert consensus on a structured approach to circular stapling anastomosis in minimally invasive left‐sided colorectal resection
Authors: Tou Samson , Gallagher Anthony G. , Bislenghi Gabriele , Farinha Rui , Wolthuis Albert ,   the CAPITAL A Study Collaborative
Published: February 2025

Aim

The aim of this work is to develop and operationally define performance metrics that characterize a reference approach to circular stapling anastomosis during minimally invasive left‐sided colorectal resection and to obtain face and content validity through a consensus meeting.

Method

Three expert colorectal surgeons with advanced experience with minimally invasive surgery, a senior behavioural scientist and a research fellow with experience in performance metrics development formed the Metrics Group. Technical support was provided by device engineers. Published guidelines, training materials, manufacturers' instructions for use and unedited videos of circular stapling anastomosis in minimally invasive left‐sided colorectal resection were used to deconstruct the task into defined, observable performance units or metrics (i.e. procedural phases, steps, errors and critical errors). The performance metrics were then subjected to detailed review by 16 expert colorectal surgeons in a modified Delphi process.

Results

Performance metrics for circular stapling anastomosis during minimally invasive left‐sided colorectal resection had three procedural phases with 32 steps, 40 errors and 38 critical errors. After the modified Delphi process the agreed performance metrics consisted of three procedural phases, 36 steps, 42 errors and 39 critical errors. A group of expert colorectal surgeons from Europe verified the face and content of these metrics. After discussion, all procedural phases received unanimous consensus by the Delphi panel.

Conclusion

Circular stapling anastomosis during the minimally invasive approach to left‐sided colorectal resection can be broken down into procedural phases and steps, with errors and critical errors known as performance metrics. We consider the metrics essential for the development of structured training in using circular stapling anastomosis in the minimally invasive approach to left‐sided colorectal resection.
Efficacy of biofilm decontamination methods of dental implant surfaces: A systematic review of in vitro studies
Authors: Abushahba Faleh , Algahawi Ahmed , Areid Nagat , Vallittu Pekka K. , Närhi Timo
Published: February 2025

This systematic review examines the decontamination techniques used to clean titanium (Ti) implant surfaces covered with in vitro bacterial biofilms. The selected studies were gathered from the PubMed and Web of Science databases. These include in vitro studies investigating decontamination methods used to clean Ti implant surfaces coated with bacterial biofilms until January 2024. The determined studies were filtered according to the PRISMA guidelines, and the Science in Risk Assessment and Policy (SciRAP) was used to assess the reporting and methodological quality of the included studies. A total of 634 full‐length peer‐reviewed articles were identified. After excluding duplicate papers between the databases and screening according to the predefined inclusion and exclusion criteria, 13 studies were included. The decontamination methods investigated included mechanical, chemical, and physical methods, either as a single or in a combined approach. Significant variability was observed among the included studies. Combining the mechanical and physical methods with a chemical yielded the most significant reduction in both single‐ and multiple‐species biofilms. The current results do not indicate that any single decontamination technique is more effective than others in eradicating bacterial biofilm from Ti surfaces; the combined approach was more advantageous than the single ones.
Surgical management of a perineal hernia in a 24‐year‐old mare
Authors: Spadari A. , Meistro F. , Saragoni G. , Rinnovati R. , Ralletti M. V.
Published: February 2025

A rare case of bilateral perineal hernia was reported in a 24‐year‐old Italian Trotter mare. The mare presented a history of chronic weight loss and bilateral perineal swelling. The right‐sided swelling displayed signs of being chronic, while the left side experienced a singular episode of acute perineal swelling, coinciding with signs of colic. Due to concerns regarding potential recurrent colic episodes and the risk of bowel entrapment, the mare was hospitalised to perform a complete clinical and diagnostic assessments, and to establish an appropriate treatment. Based on history, clinical manifestations, results of palpation and ultrasonography, it was determined that the swelling was indicative of bilateral perineal hernia. An initial attempt at surgical correction through appositional herniorrhaphy proved unsuccessful. Subsequently, a novel technique involving the transposition of the semimembranosus muscle was employed as a secondary intervention. This alternative surgical method effectively addressed the issue without any short‐ or long‐term recurrence or complications. In conclusion, perineal hernias should be included in differential diagnoses for perineal swelling in equids. Furthermore, when appositional herniorrhaphy proves ineffective, transposition of the semimembranosus muscle may be considered as a surgical option.
Unusual penetrating foot injury with complete perforation of the distal phalanx by a metal object
Authors: De Schryver M. , Gruyaert M. , Raes E. , Oosterlinck M.
Published: February 2025

A 12‐year‐old Warmblood gelding was presented with acute, nonweightbearing left hindlimb lameness. A foreign object was detected in the toe area of the solar surface. Radiographic examination confirmed foot penetration by a metal object, perforating the distal phalanx and dorsally reaching the lamellar dermis. Standing surgical exploration was performed. After manual removal of the object, a small circular opening in the dorsal hoof wall was created to facilitate debridement and flushing of the complete tract. Radiographically, the distal phalanx presented an irregular circular defect (35 × 33 mm) at the dorsal half of the sole just medial to the sagittal plane, without other lesions. The horse received broad‐spectrum antimicrobial and nonsteroidal anti‐inflammatory treatment. Lameness decreased gradually and the lesion presented progressive granulation and epithelisation. After 4 weeks, the horse was discharged from the hospital. A final cast change was performed during an ambulatory check‐up at the hospital 2 weeks later. At that stage, epithelisation was complete, and first signs of keratinisation were observed. Further follow‐up was performed by the referring veterinarian. The horse resumed its previous level of exercise in a riding school. Six‐month follow‐up did not reveal lameness; radiographically, the circular defect in the distal phalanx remained visible yet without other abnormalities.
Combination of Element Subdiscretization, Singular Element, and Displacement Jump Enrichment for Simulating Progressive Elastoplastic Fracture
Authors: Zhang Zhongxiao , Zhou Chuwei , Zhang Yinxuan , Yu Fei
Published: February 2025

In this study, a strategy combining element subdiscretization, singular element, and displacement jump enrichment was developed to simulate crack propagation in elastoplastic materials. The background element mesh is independent of the crack path. The element enveloping the crack tip is subdiscretized to subtriangular quarter‐point singular elements to represent the singularity there. The elements fully or partly split by the crack were enriched with the Heaviside function to reflect the displacement discontinuity across the two sides of the crack. The proposed method possesses an attractive advantage of being able to employ nearly all the available nonlinear models of finite element method (FEM) directly in crack tip region by using stress singular element instead of asymptotic singular function. Here, the Gurson–Tvergaard–Needleman (GTN) model was employed as crack growth law in elastoplastic materials. The proposed strategy was validated by several numerical simulations of crack propagation in elastoplastic materials including scenarios of mixed fracture mode and nonmonotonic loads.
Sol–gel fabrication of thermoelectric P‐type Ca2.5Ag0.3Ce0.2Co4O9 materials for aerospace applications
Authors: Kilinc Enes , Uysal Fatih , Sari Mucahit Abdullah , Kurt Huseyin , Celik Erdal
Published: February 2025

The article provides a comprehensive description of the synthesis and characterization of Ca2.5Ag0.3Ce0.2Co4O9 semiconducting ceramics for potential application in thermoelectric generators, particularly in the aerospace industry. These materials were synthesized using the sol–gel method, with distilled water serving as the solvent and citric acid monohydrate incorporated into expedited gel formation. The pH and turbidity values of solutions were monitored through a pH meter and turbidimeter, respectively. The produced xerogel was subjected to drying at 200°C for 2 h in an air atmosphere to remove residual moisture and volatile by‐products. The desiccated powders were then heat‐treated at 800°C for 2 h under ambient air conditions, yielding the final Ca2.5Ag0.3Ce0.2Co4O9 compound. Thermal processing of the resulting pellets was carried out at 900°C for 24 h to fabricate bulk samples. Comprehensive characterization was performed to assess thermal, structural, microstructural, and thermoelectric behaviors via DTA‐TG, XRD, XPS, SEM, and TM machines. It was found that at 800°C, a maximum power factor of .24 mW/m·K2 was achieved, derived from a Seebeck coefficient of 214.30 µV/K and electrical resistivity of 19.05 mΩ·cm at the same temperature. The synthesized ceramic materials exhibit promising thermoelectric efficiency, making them suitable for thermoelectric generator production.
Skills for a Circular Economy Transformation—A Regional Case Study From Sweden
Authors: Martin Hanna
Published: February 2025

Among the contributions on skills in economic geography and related disciplines, the skills required in a regional context for putting circular economy into practice remain largely unaddressed. Labour markets have however a strong regional dimension, and industry development and transformation is often heavily reliant on already existing skills in a region. The objective of this paper is to make explicit the skills required by employers for implementing circularity in regional manufacturing industries. Furthermore, it addresses where these skills are obtained from, and whether there is a connection to already existing industrial specialisations. The theoretical framework of the paper draws on contributions from the economic geography of labour markets as well as the circular economy. The paper is based on in‐depth interviews with companies and supporting actors engaged in circular economy development in the vehicles/automotive and the textile industries in the West Gothland region in Sweden. The findings reveal that circular economy imposes new skill demands on manufacturing industries, many of which are applicable across various industrial contexts. The industries face an increased need for material‐specific and technological skills to ensure an improved durability and separability of materials and components. At the same time, the outcomes emphasise the importance of a variety of non‐technological skills and point towards so far less addressed opportunities for learning and skill transfer between different industry contexts. Furthermore, the circular economy puts focus on a variety of low‐skill jobs that have largely been unconsidered in the literature.
Presence of Ineffective Cardiac Resynchronization Therapy Pacing Provides Insights Into Hidden Causes and Therapeutic Targets of Nonresponder
Authors: Oka Satoshi , Ueda Nobuhiko , Wada Mitsuru , Ishibashi Kohei , Nakamura Toshihiro , Miyazaki Yuichiro , Wakamiya Akinori , Kanzaki Hideaki , Izumi Chisato , Kusano Kengo
Published: February 2025

Introduction

An effective cardiac resynchronization therapy (CRT) algorithm classifies each left ventricular (LV) pace as effective or ineffective based on electrogram morphology. Loss of capture, latency, pseudo‐fusion during sinus rhythm, and rapid ventricular responses due to atrial fibrillation (AF) and premature ventricular conductions (PVCs) are potential causes of ineffective CRT pacing. However, little is known about the relationship between percentage of ineffective CRT pacing (%i‐CRT) and CRT response.

Methods and Results

Among 136 consecutive CRT recipients, we evaluated 44 patients with an effective CRT algorithm. The primary outcome was the prevalence of CRT responders, defined as a reduction in the LV end‐systolic volume by ≥ 10% 6 months after implantation. The median values of percent ventricular pacing and %i‐CRT were 97.5% (interquartile range [IQR]: 96.4%–98.3%) and 0.3% (IQR: 0.1%–1.0%), respectively. Patients in the highest quartile of %i‐CRT (%i‐CRT ≥ 1%) showed a significantly lower prevalence of CRT responders (4 [36.4%] vs. 28 [84.8%], p = 0.004) than the remaining quartiles. The univariate analysis showed that %i‐CRT ≥ 1% was negatively associated with the CRT response (odds ratio: 0.10, 95% confidence interval: 0.02–0.48). The most frequent cause of ineffective pacing was rapid ventricular responses due to AF and/or PVCs, whereas the cause of the highest %i‐CRT in this cohort was latency. A total of three nonresponders with a high %i‐CRT showed favorable responses after therapeutic interventions for their hidden causes.

Conclusion

High %i‐CRT could be associated with an unfavorable CRT response and provide insights into hidden causes and therapeutic targets.
Pregnant nurses' occupational stress and associated factors: A comparative cross‐sectional study with other healthcare workers, physical workers, and desk workers
Authors: Hino Marie , Ebina Yasuhiko , Yano Rika
Published: February 2025

Aim

To examine occupational stress levels and associated factors among pregnant nurses through a comparison with pregnant non‐nurses.

Methods

This cross‐sectional study included 1060 working pregnant women. Participants completed questionnaires including the Brief Job Stress Questionnaire, work conditions, obstetric conditions, Sense of Coherence Scale, and self‐management behaviors questionnaire. The participants were categorized into four groups: nurses, other healthcare workers, physical workers, and desk workers. Comparisons were made between the four groups and by gestational ages using Dunnett's test and chi‐squared test, and associated factors were examined using ordinal logistic regression analysis.

Results

Analysis of 847 valid responses showed that the nurse group had a higher occupational stress, higher job demand, and lower job control at any gestational age than the other profession groups. Nurses' occupational stress was associated with factors such as frequent overtime work, fewer break times, lower manager support, and lower prioritizing the fetus. Particularly, fewer break times and lower prioritizing the fetus were nurse‐specific associated factors.

Conclusions

The study showed that pregnant nurses are exposed to higher occupational stress throughout the entire pregnancy than other occupations. The stress was related to modifiable factors such as fewer break times and lower prioritizing the fetus. To manage occupational stress, pregnant nurses should avoid overtime, take breaks, and prioritize the fetus in the workplace. Hospital administrators would need to provide work coordination support and consider certain regulations regarding hazardous work restrictions for pregnant nurses. Future cohort studies are required to better understand occupational stress among pregnant nurses.
Sexual satisfaction and associated factors among patients with inflammatory bowel disease in Japan
Authors: Wakai Sayaka , Tanaka Makoto , Takai Momoko , Sakagami Kayoko , Ito Hiroaki
Published: February 2025

Aim

This study aimed to identify sexual satisfaction and related factors in Japanese patients with inflammatory bowel disease, as well as the characteristics of patients who refrained from responding to the sexual satisfaction question.

Methods

A questionnaire survey was administered to 499 patients, of whom 492 were available for the analysis. Sexual satisfaction was measured using 5‐point scale derived from “I am satisfied with my sex life” item in the Functional Assessment of Chronic Illness Therapy‐Fatigue. Patient characteristics (sex, age, marital status, and job status) were collected. Additionally, we obtained data from the scale regarding nonresponse to the sexual satisfaction, sleep deprivation status, emotional well‐being, and fatigue subscales, and collected information on disease status from the medical records, including the partial Mayo Score and Crohn's Disease Activity Index.

Results

Regarding sex life satisfaction, the most common response was somewhat (24.8%). There were 173 (35.2%) patients who refrained from answering the sexual satisfaction question. Females and those of older age tended to avoid answering the question. Impaired sexual satisfaction was also significantly associated with older age, sleep deprivation, low emotional well‐being subscale scores, and greater effects of fatigue.

Conclusion

Sexual satisfaction is related to chronic conditions in such areas as emotional well‐being, fatigue, and sleep deprivation in inflammatory bowel disease patients, even when they are in remission. These results suggest that patients with inflammatory bowel disease are sometimes reluctant to talk about sex. Therefore, it is important for medical staff to consider this issue, especially in Japan.
Biodiversity—The Cornerstone of Sustainable Aquaculture Development: Insights From the Breeding of Approved Fish Varieties for Aquaculture From 1996 to 2024 in China
Authors: Liu Zhuning , Wang Chongnv , Guo Baocheng
Published: February 2025

Aquaculture, especially fish farming, plays a critical role in sustainable food production worldwide, with human consumption of fish and fish products exceeding that of capture fisheries. While aquatic species constitute an invaluable reserve of biodiversity, the values of biodiversity in aquaculture remain largely unacknowledged. China is not only the most significant consumer but also the most prominent contributor to global aquaculture production. This study delineates the characteristics of 150 fish varieties approved for aquaculture in China between 1996 and 2024, including species diversity, habitat distribution, and trophic level of their germplasm resources, to illustrate why biodiversity matters in our food systems. Our results reveal an increasing trend in the use of native fish species, which inhabit diverse habitats and occupy higher trophic levels, in the cultivation of novel fish varieties for aquaculture. We also found that 81 (54%) of the 150 approved varieties involved multiple germplasm resources with 46 (30.7%) being interspecific. These observations emphasize the reliance of aquaculture breeding on the diversity of germplasm resources, which fundamentally depend on natural biodiversity. Taken together, the breeding practices adopted for the approved fish varieties in China highlight the significance of biodiversity conservation in the sustainable advancement of aquaculture.
Tide‐influenced depositional system recorded in southern Gondwana during the Early Permian: Post‐glacial infill of the Capané palaeovalley
Authors: Candido Mariane , Cagliari Joice , Lavina Ernesto Luiz Correa
Published: February 2025

Mixed‐energy coastal systems produce complex depositional records that can obscure the predominant processes controlling sediment deposition. This occurs mainly when the interpretation of the primary sedimentary structures is non‐unique. The Rio Bonito Formation succession infilling the Capané palaeovalley in the southern Paraná Basin exhibits records of the depositional influence of tides and waves, in which tidal deposits are predominant. However, the depositional environment has not been completely elucidated, and little is known about the significance of tides in the depositional environment. To identify the physical processes responsible for sediment deposition and reconstruct the depositional system, sedimentary facies and stratigraphic analyses of drilled cores and outcrops from the Capané palaeovalley were performed. Fourteen sedimentary facies, four facies associations and three types of sand bodies are described (tidal point bars, compound tidal dunes and offshore tidal sand ridges). The sedimentary succession records an incised valley infill comprising lowstand and transgressive systems tracts. In the deepest part of the palaeovalley, an inner portion of a fluvial‐tidal transitional environment is preserved. The lower succession along the valley is marked by the establishment of an estuarine system, which is replaced by an offshore tidal system in the upper succession, and culminates with a coastal marine environment. This interpretation differs from the wave‐dominated model previously described for this area. This study contributes to the understanding of the evolution and distribution of coal‐forming depositional systems of the Rio Bonito Formation.