bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable Reuse of Dark Archaeological Heritage Sites to Promote Ghost Tourism in Egypt: The Case of the Baron Palace
Authors: Sobaih Abu Elnasr E. , Naguib Shaimaa M.
Published: November 2022

Egypt is one of the few countries with significant archaeological sites in every region. Some of these sites have been identified as dark archaeological sites that have not been used in a long time. The study proposes a strategy for the long-term reuse of these sites through niche tourism, i.e., dark or ghost tourism, which has received little attention from decision-makers or tourism planners. Furthermore, they have received little attention from Egyptian scholars. The current study fills knowledge gaps and contributes to the preservation of archaeological sites through sustainable reuse, ultimately helping Egypt’s sustainable tourism development. Using the case of the Baron Palace, the study investigates the potential for dark and ghost tourism in Egypt, as well as the barriers and development recommendations. To achieve the study’s goal, the research adopted a qualitative approach that relied on in-depth interviews with various stakeholders. The discussions revealed that, while Egypt has many types of tourism, both dark and ghost tourism have significant potential and opportunities through the reuse of dark archaeological sites. However, there are numerous impediments to proper implementation. Recommendations were made to overcome these obstacles, achieve positive economic, social, and environmental outcomes, and ensure the long-term viability of archaeological heritage.
Transformative Education for Sustainable Consumption
Authors: García-González Esther , Albareda-Tiana Silvia , Solís-Espallargas Carmen , Jiménez-Fontana Rocío
Published: November 2022

Teachers play a key role in the construction of a more equal, fairer and sustainable world. Incorporating education for sustainable consumption into teacher training should therefore be a priority. This education should aim to develop students’ awareness of environmental issues, to encourage lifestyle changes, and to promote reducing their personal ecological footprint (EF). Training processes will hence lead to active learning approaches promoting critical thinking about production and consumption patterns, linking the curriculum content to real life, and involving students in activities that reduce their EF. This paper presents research carried out at three Spanish faculties of education. The main goal is to analyse the relationship between active teaching and learning strategies, and the reduction of the students’ individual EF. Pre- and post-test questionnaires were used to collect data. A total of 93 primary education degree students took part in this study. The results show the students’ individual EF decreased at the end of the learning processes. This proves that active teaching and learning strategies can foster sustainable consumption habits, and more sustainable lifestyles in general, in student teachers.
Biofortified Rocket (Eruca sativa) with Selenium by Using the Nutrient Film Technique
Authors: Nascimento Carolina Seno , Nascimento Camila Seno , Lopes Guilherme , Carrasco Gilda , Gratão Priscila Lupino , Cecílio Filho Arthur Bernardes
Published: November 2022

Selenium (Se) is an essential micronutrient for humans, but most foods are Se deficient, mainly because of its low content in the soil. A Se-deficient diet results in increased susceptibility to cardiovascular disease, cancer, and hyperthyroidism. Agronomic biofortification is a good alternative to increase Se in food. This study investigated the effect of Se on the growth, yield, and biofortification of the rocket. Plants were grown in a hydroponic system. Seven Se concentrations (0, 10, 20, 30, 40, 50, and 60 µM) were evaluated using sodium selenate. Growth, yield, lipid peroxidation, hydrogen peroxide content, and the enzymatic activity of catalase and ascorbate peroxidase were influenced by the Se concentration. Considering the evaluated parameters, 10–30 µM Se promoted the best results, and with 20 µM, the higher yield. Rocket plants treated with Se in the nutrient solution were biofortified, showing Se contents of 598.96 to 1437.56 mg kg−1 in the dry mass, higher than plants cultivated in a nutrient solution without Se, which presented 167.84 mg kg−1 of Se. Se concentrations of 10–30 µM in the nutrient solution were beneficial for rocket plants, while concentrations above 50 µM were toxic to the plants.
Functional Diversity and Primary Production Predict Future Patterns of Periphyton Productivity after Species Extinction
Authors: Dunck Bárbara , Colares Lucas , Rodrigues Liliana , Cássio Fernanda , Pascoal Cláudia
Published: November 2022

Understanding of the trait-based ecology of the periphytic algal community has increased in the last decade. However, the relationship between their functional diversity and ecosystem functions, such as primary production, has been speculated on, but yet not proven. Human impacts promote changes in biotic communities leading to a risk of extinction, with consequences for the functioning of aquatic ecosystems. In this study, we unraveled the associations between the taxonomic and functional components of periphytic algal diversity, stream eutrophication, and productivity patterns. Furthermore, we simulated future patterns of species extinction to predict how productivity may change when facing extinction. Primary production and taxonomic and functional diversity of the periphytic algal communities were estimated in five streams across a trophic gradient in the Ave River basin (northwest Portugal). Our results demonstrated that eutrophication led to a unimodal pattern of taxonomic diversity, while functional diversity tended to increase with increasing eutrophication. We found that only functional diversity had a positive association with primary production. The extinction estimations indicated that almost all species found in our study were at high extinction risk. When we spatially scaled our extinction simulations, we found poor-productive streams after the extirpation of a few species. However, at the regional scale, the ecosystem supports the extinction of at least 40% of species before turning into a poor-productive system. Intermediate levels of disturbance are probably beneficial for the diversity of periphytic algal communities, to a certain extent. Moreover, functionally diverse communities were more productive, and the alleged future extinction of species is likely to lead to poor-productive streams if regionally focused conservation initiatives are not implemented. We recommend that, using simulations of functional extinction, it is possible to infer how the loss of these microorganisms could alter ecosystem functioning, to better predict human impacts on aquatic ecosystems.
Fatigue and Recovery of Muscles for Pulling Tasks
Authors: Yi Cannan , Zuo Huali , Zhao Caijun , Li Kai-Way , Hu Hong , Tang Fan , Long Tong
Published: November 2022

Manual materials handling (MMH) contributes to musculoskeletal disorders (MSDs) in the workplace. The development and recovery of muscle fatigue are essential in work/rest arrangements for MMH tasks. A pulling experiment, including a muscle fatigue test and a muscle fatigue recovery test, was conducted. In the muscle fatigue test, the participant performed a pulling task on a treadmill with a walking velocity of 1 km/h until they could no longer do so. The load was either 30 or 45 kg. The maximum endurance time (MET) was recorded. The pull strength (PS) of the participant both before and after the pulling task was measured. The subjective ratings of muscle fatigue after the pulling task were recorded. In the muscle fatigue recovery test, the participant took a rest after performing the pulling task. The participants reported their subjective ratings of muscle fatigue on the CR-10 scale after taking a rest for a time period t, where t = 1, 2,…, 6 min. The PS of the participant was then measured again. It was found that the load significantly affected the MET for pulling tasks. The load was insignificant to the decrease of the PS, but was significant to the decrease rate (PS decrease per min) of the PS. The PS decrease rate for the 45 kg condition (30.8 ± 16.5 N/min) was significantly higher (p < 0.05) than that of the 30 kg condition (15.4 ± 5.5 N/min). The recovery time significantly affected the PS and CR-10. Two MET models were established to explore the development of muscle fatigue in pulling tasks. A PS model was constructed to describe the recovery of muscle force. A CR-10 model was proposed to show the subjective ratings of recovery. These models are beneficial for determining the work/rest allowance for pulling tasks.
Social Frailty and Meaningful Activities among Community-Dwelling Older Adults with Heart Disease
Authors: Akasaki Yoshihiko , Tabira Takayuki , Maruta Michio , Makizako Hyuma , Miyata Masaaki , Han Gwanghee , Ikeda Yuriko , Nakamura Atsushi , Shimokihara Suguru , Hidaka Yuma , Kamasaki Taishiro , Kubozono Takuro , Ohishi Mitsuru
Published: November 2022

Patients with heart disease are more likely to experience social frailty due to physical inactivity, which may affect meaningful activities such as hobbies. This study aimed to investigate (1) the association between heart disease and social frailty in community-dwelling older adults and (2) the characteristics of meaningful activities in community-dwelling older adults with heart disease. Data from 630 older adults who participated in a community-based health survey were obtained, including clinical history, meaningful activities, social frailty and psychosomatic functions. Participants were divided into two groups: those with heart disease (n = 79) and those without (n = 551), and comparisons were made. Social frailty was observed in 23.7% of participants with heart disease, and logistic regression revealed significant associations with heart disease and social frailty after adjusting for potential covariates (OR, 1.97; 95% CI, 1.06 3.67; p = 0.032). Participants with heart disease did not differ significantly in terms of satisfaction or performance; their frequency of engagement in meaningful activities was significantly lower than without heart disease (p = 0.041). These results suggest that heart disease and social frailty are associated in community-dwelling older adults, and that this demographic is inclined to engage in meaningful activities less frequently.
Factors Associated with the Duration of Breastfeeding: The Practices of Mexican Mothers in a Megacity and in the Agricultural Town
Authors: Castillo-Cruz Rocio Aidee , Iracheta-Gerez Maria de la Luz , Macias-Parra Mercedes , Esparza-Aguilar Marcelino
Published: November 2022

Background: Breast milk is irreplaceable for healthy development. In Mexico, by 2019, the prevalence of exclusive breastfeeding (EBF) was low and the use of breastmilk substitutes (BMSs) was high. Objective: The aim of this work was to evaluate the maternal and child characteristics related to breastfeeding (BF) duration and to the introduction of BMSs for residents of Mexico City (CdMX) and an agricultural town in Morelos. Methods: A cross-sectional study was conducted with 160 mother–child binomials (0–15 months of age) from the megacity CdMX and the agricultural town. Outcomes: EBF and total breastfeeding (TBF) duration, age of transition to BMSs, and the introduction of complementary feeding (CF) were assessed. Associations with maternal and infant factors were assessed using Cox models. Results: The prevalence of EBF in the joint samples at 5.9 months was 32.6% and 5.8% at 6 months. EBF was favored under the following conditions: living in CdMX, receiving prenatal care, no newborn hospitalization, and breastmilk provided as first food at birth. TBF was prolonged under the following conditions: older mother, female children, rooming-in care during puerperium, receiving BF upon discharge after birth, cohabiting with extended family, and having no siblings. The introduction of BMSs predominated under the following conditions: living in an agricultural town, BMSs given after birth before discharge, younger mother, worker mother, and lack of prenatal care. The early introduction of CF (before the fourth month) was 2% for CdMX and 14% for the agricultural town. Conclusions: The agricultural population had a higher risk of the premature interruption of EBF/TBF and the early introduction of BMSs and CF. Protective factors were family-friendly environments and being born in a baby-friendly hospital.
Factors Affecting Cultural Competence in a Sample of Nursing Students during the Prolonged COVID-19 Pandemic in Republic of Korea: A Cross-Sectional Study
Authors: An Hyeran , Jin Juhyun , Kim Taehyun
Published: November 2022

Globally, foreign citizens, particularly ethnic and racial minorities, experienced discrimination and received imbalanced medical services and insufficient economic resources during the COVID-19 pandemic. This study aimed to examine the factors that affect the cultural competence of nursing students. This is descriptive cross-sectional study adheres to Strengthening the Reporting of Observational studies in Epidemiology (STROBE) guidelines. A convenience sample of 235 nursing students from two nursing colleges in D city completed an online Google Forms questionnaire from 9 August to 12 August 2022. The self-report questionnaire included a sociodemographic data form, a cultural intelligence scale, an ethnocentrism scale, a global competence scale, and a cultural competence scale. The mean score of cultural competence was 95.39 ± 15.64 (out of 135 points); cultural competence was significantly positively correlated with cultural intelligence and global competence (p < 0.001), and significantly negatively correlated with ethnocentrism (p < 0.001). The factors that significantly affected cultural competence were cultural intelligence (β = 0.31, p < 0.001) and global competence (β = 0.37, p < 0.001). The explanatory power of these effects was 47.3%. To improve the cultural competence of nursing students, it is necessary to develop, apply, and evaluate the results of curriculum and programs that can enhance the cultural intelligence and global competence of nursing students.
Proposed Safety Guidelines for Patient Assistants in an Open MRI Environment
Authors: Oh Sukhoon , Hong Seon-Eui , Choi Hyung-Do
Published: November 2022

The wide-open side of an open magnetic resonance imaging (MRI) system allows a patient to easily contact the patient assistant during MRI scans. A wide-open-shaped magnet is highly effective when interventional procedures are necessary. Patient assistants can provide comfort by holding a part of the patient’s body. Because current regulations or guidelines are concerned with only patient radio frequency (RF) safety, investigations on the safety of patient assistants exposed to high-magnetic field MRI (up to 1.2 T) are required. In this study, five different poses of patient assistants were numerically simulated at a 1.2 T open MRI system to determine the impact of poses on the RF exposure level. The 10-g averaged specific absorption rate (SAR) levels were analyzed for the poses of each patient assistant wearing gloves. Compared with the patient, up to 29.8% of the patient SAR was observed in the patient assistant. When the patient assistant wore latex gloves, a 63.7% reduction in the 10-g averaged SAR level was observed, which could be a remedy to minimize possible RF hazards. To prevent possible RF hazards during MRI scans, certain clauses regarding the patient assistant’s poses or wearing gloves must be added to the existing MRI screening forms.
Environmental Factors in the Rehabilitation Framework: Role of the One Health Approach to Improve the Complex Management of Disability
Authors: Lippi Lorenzo , de Sire Alessandro , Folli Arianna , Turco Alessio , Moalli Stefano , Ammendolia Antonio , Maconi Antonio , Invernizzi Marco
Published: November 2022

Environment factors play a crucial implication in human health, with strong evidence suggesting that several biological, chemical, physical and social factors could be possible targets to implement effective strategies for human health promotion. On the other hand, a large gap of knowledge still exists about the implications of environmental factors in terms of functional impairment and disability, while the integration of an environmental-based approach in the therapeutic care of patients affected by disabilities remains still challenging. In this scenario, the One Health approach has been recently introduced in clinical care and aims to optimize health outcomes by recognizing the interconnection between people and the environment. Concurrently, the “Rehabilitation 2030 Initiative” proposed in 2017 by the WHO emphasized the need to integrate environmental-based strategies to promote rehabilitation across different health systems and different nations. However, no previous study underlined the potential implications of the One Health approach in the rehabilitation setting, nor the role of a comprehensive rehabilitation approach focused on environmental factors. Therefore, the aim of this narrative review was to present a comprehensive overview of the data currently available assessing the close relationship between rehabilitation and the environment to provide a different perspective on the comprehensive care of patients affected by disability.
Effects of Distracting Behaviors on Driving Workload and Driving Performance in a City Scenario
Authors: Luo Shuang , Yi Xinxin , Shao Yiming , Xu Jin
Published: November 2022

Distractors faced by drivers grow continuously, and concentration on driving becomes increasingly difficult, which has detrimental influences on road traffic safety. The present study aims to investigate changes in driving workload and driving performance caused by distracting tasks. The recruited subjects were requested to drive along a city route in a real vehicle and perform three secondary tasks sequentially. Electrocardiography and driving performance were measured. Heart rate variability (HRV) was adopted to quantitatively analyze the driving workload. Findings show that: (i) increments are noticed in the root mean square differences of successive heartbeat intervals (RMSSD), the standard deviation of normal-to-normal peak (SDNN), the heart rate growth rate (HRGR), and the ratio of low-frequency to high-frequency powers (LF/HF) compared to undistracted driving; (ii) the hands-free phone conversation task has the most negative impacts on driving workload; (iii) vehicle speed reduces due to secondary tasks while changes in longitudinal acceleration exhibit inconsistency; (iv) the experienced drivers markedly decelerate during hands-free phone conversation, and HRGR shows significant differences in both driving experience and gender under distracted driving conditions; (v) correlations exist between HRV and driving performance, and LF/HF correlates positively with SDNN/RMSSD in the hands-free phone conversation and chatting conditions while driving.
Caring for a Family Member with Psychosis or Bipolar Disorder Who Has Experienced Suicidal Behaviour: An Exploratory Qualitative Study of an Online Peer-Support Forum
Authors: Marshall Paul , Jones Steven , Gooding Patricia , Robinson Heather , Lobban Fiona
Published: November 2022

Background. The likelihood of suicidal behaviour is elevated amongst people with psychosis or bipolar disorder. This study aimed to understand how carers experience supporting family members with psychosis or bipolar disorder who have also experienced suicidal behaviour. Methods. A qualitative thematic analysis of online peer forum posts was carried out on the Relatives Education and Coping Toolkit (REACT) website, an online intervention for carers of people with psychosis and bipolar disorder. Analysis was based on 178 posts by 29 forum users. Posts were selected based on their relevance to suicidal behaviour. Results. Three themes were generated. “Suicide as the ultimate threat” highlights fears emerging from carers’ difficulties with understanding and managing suicidal behaviour. “Bouncing from one crisis to another” reflects carers’ experiences of recurring crises and the challenges of relying on emergency healthcare support. “It definitely needs to be easier to get help” emphasises carers’ desires to be acknowledged by healthcare professionals and included in support offered to service users. Conclusions. Digital platforms, including online forums, brief interventions such as safety planning, and interagency crisis models, hold the potential to meet carers’ needs in this context. However, further research is required to investigate the effectiveness and implementation of these approaches.
Special Care Patients and Caries Prevalence in Permanent Dentition: A Systematic Review
Authors: Pecci-Lloret Miguel Ramón , Pecci-Lloret María Pilar , Rodríguez-Lozano Francisco Javier
Published: November 2022

Due to the increase in the population with special needs and the significant difficulty in their dental management, it is essential to analyze the caries prevalence in this group of patients. The systematic review was conducted following the PRISMA statement. A search was performed on 9 May 2022 and updated on 5 June 2022, in three databases: Pubmed, Scielo, and Cochrane library. Studies involving the analysis of caries in permanent teeth in patients with special needs were included. A total of 1277 studies were analyzed and 21 studies were selected. Quality assessments were performed using an adapted version of the STROBE guidelines. Among the analyzed groups (intellectual disabilities, human immunodeficiency virus infection, schizophrenia, down syndrome, drug addicts, adult heart transplant, kidney disease, diabetic, autism, psychiatric patients, cerebral palsy, and hemophilia), the highest prevalence of caries was observed in patients with intellectual disability, without differences between genders. However, there is a need for more studies with standardized methods for caries diagnosis to further investigate the prevalence of caries in permanent teeth in patients with special needs.
Validation of the Global Lung Function Initiative 2012 Spirometry Reference Values in a Healthy Italian Working Population
Authors: Fontana Luca , Cioffi Dante Luigi , Leso Veruscka , D’Ausilio Emanuele , Pacella Daniela , Fedele Mauro , Maniscalco Mauro , Iavicoli Ivo
Published: November 2022

Background: Several studies showed important differences in the interpretation of spirometry based on different reference values, in particular by comparing European Respiratory Society (ERS) 1993 and Global Lung Function Initiative (GLI) 2012. The validation of new reference values in local populations is essential before they can be used in an appropriate manner. This study aimed to investigate the fit of GLI reference values in a healthy Italian working population. Methods: Spirometry data were collected in 1355 workers during their health surveillance medical examination conducted for exposure to chemical and biological risk factors. A single portable spirometer that met the ATS/ERS recommendations for occupational testing was used and calibrated daily. Results: Average z-score were −0.13 (with a median of −0.17), −0.25 (with a median of −0.24), and 0.18 (with a median of 0.17) for FEV1, FVC, and FEV1/FVC ratio, respectively. Considering only the normal-weighted workers, the average z-scores were −0.07 (with a median of −0.16), −0.15 (with a median of −0.16), and 0.07 (with a median of 0.02) for FEV1, FVC, and FEV1/FVC ratio, respectively. Conclusions: GLI 2012 reference values fit the Italian data satisfactorily, resulting as more accurate than ERS 1993, especially in women, normal-weighted subjects, aged 30−50 years, and for height < 165 cm.
New Dimension on Quality of Life Differences among Older Adults: A Comparative Analysis of Digital Consumption in Urban and Rural Areas of China
Authors: Zhang Zhizheng , Wei Wentao , Zhu Tianlu , Zhou Ming , Li Yajun
Published: November 2022

The purpose of this study was to compare the variability in quality of life in the area of digital consumption among older adults in urban and rural China during the COVID-19 pandemic. This study proposed a low-cost mixed research method, and the methodology used a quantitative study of a large regional sample combined with a qualitative study of a small regional sample. Data for the large-scale area sample were obtained from the China family panel study (CFPS) dataset, and data for the small-scale regional sample were obtained from Nanjing, China. The quantitative analysis of the large-scale regional sample used the least squares regression analysis (OSL) and propensity score matching (PSM). The qualitative analysis of the small-scale regional sample used the selection optimization and compensation (SOC) model. The findings show that economic income is a direct driver of digital consumption. Digital consumption had a significant positive relationship with the quality of life for urban and rural older adults. In addition, the study established the semantic network relationships of the coping strategies of digital consumption of older adults and their drivers. Finally, the theoretical and practical implications of these findings are discussed in the context of other related studies.
Prevalence of Compassion Fatigue and Its Association with Professional Identity in Junior College Nursing Interns: A Cross-Sectional Study
Authors: Yi Li-Juan , Cai Jian , Ma Li , Lin Hang , Yang Juan , Tian Xu , Jiménez-Herrera Maria F.
Published: November 2022

Background: The issue of compassion fatigue among clinical nurses has received considerable attention, particularly during the COVID-19 pandemic. Yet, the current status of compassion fatigue among junior college nursing interns remains unclear. Additionally, professional identity can modulate the impact of compassion fatigue or burnout on psychological well-being; however, whether professional identity still works in this group is also unclear. This study aimed to reveal the current status of compassion fatigue among nursing interns in junior colleges and also investigate the association between compassion fatigue and professional identity. Methods: This cross-sectional survey evaluated the levels of participants’ compassion fatigue (The Compassion Fatigue Short Scale) and professional identity (Professional Identity Scale) in 2256 nursing interns. Results: The mean score of compassion fatigue was 44.99, and 19.5% of the participants scored above The Compassion Fatigue Short Scale median scores for compassion fatigue. A moderate negative correlation was detected between compassion fatigue and professional identity. Conclusions: The level of compassion fatigue among nursing interns is low but nearly one in five nursing students is at risk of compassion fatigue. More attention should be paid to nursing interns with a high risk of compassion fatigue. Future studies are warranted to explore which pathways could mediate the relationship between professional identify and comparison fatigue.
Toxicity Assessment of Curculigo orchioides Leaf Extract Using Drosophila melanogaster: A Preliminary Study
Authors: Kushalan Sharanya , D’Souza Leonard Clinton , Aloysius Khyahrii , Sharma Anurag , Hegde Smitha
Published: November 2022

Curculigo orchioides is used in Indian and Chinese traditional medicinal systems for various health benefits. However, its toxicological effects are mostly unknown. This study assesses the potential toxicity of aqueous leaf (A.L.) extract of C. orchioides using Drosophila melanogaster as an experimental model. Preliminary phytochemical tests were followed by the Fourier transform infrared (FTIR) tests to identify the functional group in the A.L. extract of C. orchioides. Drosophila larvae/adults were exposed to varying concentrations of C. orchioides A.L. extract through diet, and developmental, lifespan, reproduction, and locomotory behaviour assays were carried out to assess the C. orchioides toxicity at organismal levels. The cellular toxicity of A.L. extract was examined by analysing the expression of heat shock protein (hsps), reactive oxygen species (ROS) levels, and cell death. The FTIR analysis showed the presence of functional groups indicating the presence of secondary metabolites like saponins, phenolics, and alkaloids. Exposure to A.L. extract during development resulted in reduced emergence and wing malformations in the emerged fly. Furthermore, a significant reduction in reproductive performance and the organism’s lifespan was observed when adult flies were exposed to A.L. extract. This study indicates the adverse effect of C. orchioides A.L. extract on Drosophila and raises concerns about the practice of indiscriminate therapeutic use of plant extracts.
Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis
Authors: Konarski Wojciech , Poboży Tomasz , Kotela Andrzej , Śliwczyński Andrzej , Kotela Ireneusz , Hordowicz Martyna , Krakowiak Jan
Published: November 2022

Avascular osteonecrosis (AVN) is caused by the disrupted blood supply to the bone. Most AVN cases occur in the femoral head, but other sites might be affected as well, including the jaw or distal bones of the extremities. Previous studies suggested that diabetes could increase the risk of AVN of the jaw, but the relationship between diabetes and AVN in other bone sites is unclear. This systematic review and meta-analysis aimed to summarize the evidence from studies that had reported on the occurrence of AVN in sites other than the jaw, depending on the diagnosis of diabetes. Overall, we included 6 observational studies carried out in different populations: primary or secondary AVN of the femoral head, Takayasu arteritis, general population, kidney transplant recipients, systemic lupus erythematosus, and primary brain tumors. A random-effects meta-analysis showed that the risk of AVN in sites other than the jaw was non-significantly increased in patients with diabetes (odds ratio: 1.90, 95% confidence interval: 0.93–3.91). The pooled estimate increased and was significant after the exclusion of one study (2.46, 1.14–5.32). There was a significant heterogeneity (I2 = 65%, tau2 = 0.48, p = 0.01; prediction interval, 0.21–16.84). There was no significant publication bias (p = 0.432). In conclusion, diabetes could increase the risk of AVN in sites other than the jaw, but the available evidence is limited. There is a need for large, well-designed, population-based studies.
Awareness and Needs of Smoking Cessation Services for Female Emotional Laborers, Parcel Delivery Workers, Transportation Workers, and Construction Workers in South Korea
Authors: Lee Dahyeon , Lee Kang-Sook , Kim Haena , Lee Yeonwoo , Lee Mi-Ji , Lee Hyunkyung , Myong Jun-Pyo , Kim Hyekyeong , Lee Jakyoung
Published: November 2022

Although South Korea has implemented various smoking cessation services, women who are emotional laborers, as well as parcel delivery, transportation, and construction workers, have poor access to these services. This study evaluated the smoking-related characteristics of workers in these four occupations as well as the awareness of and need for smoking cessation services. In total 808 workers in these four occupations aged 19 years and above were recruited nationwide and had their data analyzed. The participants’ age, marital status, number of work hours per week, job-related stress, age when they started smoking, average number of cigarettes a day, types of tobacco products, close relationships to others who smoke, number of attempts to quit smoking, plans to quit smoking, awareness of cessation services, prior utilization of cessation services, and need for cessation services were surveyed. Compared with parcel delivery workers, female emotional laborers and transportation and construction workers had more attempts to quit smoking, plans to quit smoking, and prior utilization of smoking cessation services, moreover, construction workers had a significantly lower awareness of smoking cessation services. Parcel delivery workers need smoking cessation programs, mobile applications to help them quit smoking, and improvements in their work environments. Cessation services and education should be promoted at workplaces and among managers.
Investigating the Associations of ADHD Symptoms, Impulsivity, Physical Exercise, and Problematic Pornography Use in a Chinese Sample
Authors: Zhang Ying , Chen Lijun , Jiang Xiaoliu , Bőthe Beáta
Published: November 2022

Investigating the relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms and impulsivity will benefit our understanding of the concept of problematic pornography use (PPU), and revealing predisposing and malleable moderators of PPU will be beneficial for its prevention and intervention. The current study not only aimed to observe these relationships, but also explored the potential moderating role of physical exercise in the general population. A total of 600 Chinese adults (Mage = 32.31, SDage = 12.40, 39.8% women) were recruited and completed an online survey. The results showed that participants with regular exercise scored lower than those without exercise on ADHD, impulsivity, and PPU (all ps < 0.001). Using latent moderated structural equations (LMS), the findings revealed that the relationship between ADHD symptoms and PPU was mediated by impulsivity, and physical exercise moderated this relationship (B = −0.14, p = 0.048). Specifically, when individuals’ physical exercise was higher than 0.84 standard deviations above the mean, the positive predictive effect of impulsivity on PPU was not significant. These findings indicate the important role of impulsivity in the relationship between ADHD and PPU, and physical exercise could be a meaningful component of interventions among individuals experiencing PPU.
Measuring the Air Quality Using Low-Cost Air Sensors in a Parking Garage at University of Minnesota, USA
Authors: Gonzalez Andres , Boies Adam , Swanson Jacob , Kittelson David
Published: November 2022

The concentration of air pollutants in underground parking garages has been found to be higher compared to ambient air. Vehicle emissions from cold starts are the main sources of air pollution in underground parking garages. Eight days of measurements, using low-cost air sensors, were conducted at one underground parking garage at the University of Minnesota, Minneapolis. The CO, NO, NO2, and PM2.5 daily average concentrations in the parking garage were measured to be higher, by up to more than an order of magnitude, compared to the ambient concentration. There is positive correlation between exit traffic flow and the air concentrations in the parking garage for lung deposited surface area (LDSA), CO2, NO, and CO. Fuel specific emission factors were calculated for CO, NO, and NOx. Ranging from 25 to 28 g/kgfuel for CO, from 1.3 to 1.7 g/kgfuel for NO, and from 2.1 to 2.7 g/kgfuel for NOx. Regulated emissions were also calculated for CO and NOx with values of 2.4 to 2.9 and 0.19 to 0.25 g/mile, respectively. These emissions are about 50% higher than the 2017 U.S. emission standards for CO and nearly an order magnitude higher for NOx.
Identification of a Novel Anti-HIV-1 Protein from Momordica balsamina Leaf Extract
Authors: Coleman Morgan I. , Khan Mahfuz , Gbodossou Erick , Diop Amad , DeBarros Kenya , Duong Hao , Bond Vincent C. , Floyd Virginia , Kondwani Kofi , Montgomery Rice Valerie , Villinger Francois , Powell Michael D.
Published: November 2022

Our lab investigates the anti-HIV-1 activity in Momordica balsamina (M. balsamina) leaf extract. Traditional Senegalese healers have used M. balsamina leaf extract as a part of a plant-based treatment for HIV/AIDS infections. Our overall goal is to define and validate the scientific basis for using M. balsamina leaf extract as a part of the traditional Senegalese treatment. As an initial characterization of this extract, we used activity-guided fractionation to determine the active ingredient’s solubility and relative size. We found that M. balsamina leaf extract inhibits HIV-1 infection by >50% at concentrations of 0.02 mg/mL and above and is not toxic over its inhibitory range (0–0.5 mg/mL). We observed significantly more antiviral activity in direct water and acetonitrile extractions (p ≤ 0.05). We also observed significantly more antiviral activity in the aqueous phases of ethyl acetate, chloroform, and diethyl ether extractions (p ≤ 0.05). Though most of the antiviral activity partitioned into the aqueous layers, some antiviral activity was present in the organic layers. We show that the active agent in the plant extracts is at least 30 kD in size. Significantly more antiviral activity was retained in 3, 10, and 30 kD molecular weight cutoff filters (p ≤ 0.05). In contrast, most of the antiviral activity passed through the 100 kD filter (p ≤ 0.05). Because the active anti-HIV-1 agent presented as a large, amphiphilic molecule we ran the purified extract on an SDS-page gel. We show that the anti-HIV-1 activity in the leaf extracts is attributed to a 30 kDa protein we call MoMo30. This article describes how MoMo30 was determined to be responsible for its anti-HIV-1 activity.
Stability of Attention Performance of Adults with ADHD over Time: Evidence from Repeated Neuropsychological Assessments in One-Month Intervals
Authors: Guo Nana , Koerts Janneke , Tucha Lara , Fetter Isabel , Biela Christina , König Miriam , Bossert Magdalena , Diener Carsten , Aschenbrenner Steffen , Weisbrod Matthias , Tucha Oliver , Fuermaier Anselm B. M.
Published: November 2022

Neuropsychological assessments of attention are valuable sources of information in the clinical evaluation of adults with attention-deficit/hyperactivity disorder (ADHD). However, it is unclear whether the attention performance of adults with ADHD is stable or fluctuates over time, which is of great importance in the interpretation of clinical assessments. This study aimed to explore the stability of attention performance of adults with ADHD in repeated assessments at one-month intervals. Twenty-one adults diagnosed with ADHD took part in this study by completing selective attention and vigilance tests three times, each one month apart. Test scores of participants were compared with and interpreted based on test norms. A considerable proportion of ‘below average’ performance scores were observed in most of the variables of selective attention and vigilance in all three assessments. Further, selective attention and vigilance performance scores did not differ significantly between the three repeated assessments. Finally, the majority of participants received consistent test score interpretations across the three repeated assessments. This study confirms previous research and highlights abnormal selective attention and vigilance performance in adults with ADHD. Further, this study preliminarily demonstrates relatively stable attention performance across repeated assessments, which has the potential to support clinical assessment, treatment planning, and evaluation.
Resident Satisfaction of Urban Green Spaces through the Lens of Landsenses Ecology
Authors: He Sinan , Chen Dingkai , Shang Xiaoqi , Han Linwei , Shi Longyu
Published: November 2022

Residents’ satisfaction of urban green space has been widely detected in living environments around the world. Most previous reports were performed with objective indicators to reflect the characteristics of vegetation and landscapes of residential green space. However, subjective senses as impact factors in the evaluation of residents’ satisfaction based on landsenses ecology are scarce. To address this, in this study, physical perception, aesthetic cognition, and psychological cognition as latent variables in a structural equation model were investigated to determine the residents’ satisfaction in Xiamen, in southeast China, a famously high green space coverage region. The results indicate that physical perception is the fundamental condition to improve residents’ satisfaction, while aesthetic cognition and psychological cognition are the direct factors that influenced residents’ satisfaction. Residents exhibit a preference for the residential green space which contains more biodiversity and landscape diversity, a higher biomass, and greater openness. In addition, the residents’ perception significantly related to greenspace characteristics. The results provide a scientific basis for urban green space planning and optimization of ecological resources’ allocation.
The Impact of Childhood Socioeconomic Status on Adolescents’ Risk Behaviors: The Role of Physiological and Psychological Threats
Authors: Geng Xiaowei , Xu Jinrong , Li Yicong , Zhang Feng , Sun Xinye , Yu Hongyang
Published: November 2022

Adolescence is a period of high levels of risk behavior. The present research aims to examine the influences of childhood socioeconomic status (SES) on risk behaviors in gain or loss domains among adolescents and the roles of threats in this effect. In experiment 1, a total of 107 adolescents (Mage = 14.80; SDage = 1.15) were asked to complete the childhood socioeconomic status scale before they took part in a risk behavior task under the gain and loss situation. A total of 149 adolescents (Mage = 14.24; SDage = 1.11) in experiment 2a and 139 adolescents (Mage = 13.88; SDage = 1.09) in experiment 2b completed the childhood socioeconomic status scale before they took part in a risk behavior task under the gain and loss situation under physiological threats and psychological threats, respectively. The results showed that high-childhood-SES adolescents tend to take more risks than low-childhood-SES adolescents in the gain domain, while low-childhood-SES adolescents tend to take more risks than high-childhood-SES adolescents in the loss domain. Threats amplified the impact of childhood socioeconomic status on adolescents’ risk behaviors in the gain and loss domains. When a physiological threat or psychological threat was primed, compared to the control group, in the gain situation, the extent to which high-childhood-SES adolescents showed greater risk seeking than low-childhood-SES adolescents became larger; in the loss domain, the extent to which low-childhood-SES adolescents showed greater risk seeking than high-childhood-SES adolescents became larger.
MT1-MMP Expression Levels and Catalytic Functions Dictate LDL Receptor-Related Protein-1 Ligand Internalization Capacity in U87 Glioblastoma Cells
Authors: Pratt Jonathan , Haidara Khadidja , Annabi Borhane
Published: November 2022

Modulations in cell surface receptor ectodomain proteolytic shedding impact on receptor function and cancer biomarker expression. As such, heavily pursued therapeutic avenues have exploited LDL receptor-related protein-1 (LRP-1)-mediated capacity in internalizing Angiopep-2 (An2), a brain-penetrating peptide that allows An2–drug conjugates to cross the blood–brain tumor barrier (BBTB). Given that LRP-1 is proteolytically shed from the cell surface through matrix metalloproteinase (MMP) activity, the balance between MMP expression/function and LRP-1-mediated An2 internalization is unknown. In this study, we found that membrane type-1 (MT1)-MMP expression increased from grade 1 to 4 brain tumors, while that of LRP-1 decreased inversely. MMP pharmacological inhibitors such as Ilomastat, Doxycycline and Actinonin increased in vitro An2 internalization by up to 2.5 fold within a human grade IV-derived U87 glioblastoma cell model. Transient siRNA-mediated MT1-MMP gene silencing resulted in increased basal An2 cell surface binding and intracellular uptake, while recombinant MT1-MMP overexpression reduced both cell surface LRP-1 expression as well as An2 internalization. The addition of Ilomastat to cells overexpressing recombinant MT1-MMP restored LRP-1 expression at the cell surface and An2 uptake to levels comparable to those observed in control cells. Collectively, our data suggest that MT1-MMP expression status dictates An2-mediated internalization processes in part by regulating cell surface LRP-1 functions. Such evidence prompts preclinical evaluations of combined MMP inhibitors/An2–drug conjugate administration to potentially increase the treatment of high-MT1-MMP-expressing brain tumors.
Flavones, Flavonols, Lignans, and Caffeic Acid Derivatives from Dracocephalum moldavica and Their In Vitro Effects on Multiple Myeloma and Acute Myeloid Leukemia
Authors: Jöhrer Karin , Galarza Pérez Mayra , Kircher Brigitte , Çiçek Serhat Sezai
Published: November 2022

Phenolic plant constituents are well known for their health-promoting and cancer chemopreventive properties, and products containing such constituents are therefore readily consumed. In the present work, we isolated 13 phenolic constituents of four different compound classes from the aerial parts of the Moldavian dragonhead, an aromatic and medicinal plant with a high diversity on secondary metabolites. All compounds were tested for their apoptotic effect on myeloma (KMS-12-PE) and AML (Molm-13) cells, with the highest activity observed for the flavone and flavonol derivatives. While diosmetin (6) exhibited the most pronounced effects on the myeloma cell line, two polymethylated flavones, namely cirsimaritin (1) and xanthomicrol (3), were particularly active against AML cells and therefore subsequently investigated for their antiproliferative effects at lower concentrations. At a concentration of 2.5 µM, cirsimaritin (1) reduced proliferation of Molm-13 cells by 72% while xanthomicrol (3) even inhibited proliferation to the extent of 84% of control. In addition, both compounds were identified as potent FLT3 inhibitors and thus display promising lead structures for further drug development. Moreover, our results confirmed the chemopreventive properties of flavonoids in general, and in particular of polymethylated flavones, which have been intensively investigated especially over the last decade.
Establishment and Validation of a New Analysis Strategy for the Study of Plant Endophytic Microorganisms
Authors: Chen Feng , Wang Xianjin , Qiu Guiping , Liu Haida , Tan Yingquan , Cheng Beijiu , Han Guomin
Published: November 2022

Amplicon sequencing of bacterial or fungal marker sequences is currently the main method for the study of endophytic microorganisms in plants. However, it cannot obtain all types of microorganisms, including bacteria, fungi, protozoa, etc., in samples, nor compare the relative content between endophytic microorganisms and plants and between different types of endophytes. Therefore, it is necessary to develop a better analysis strategy for endophytic microorganism investigation. In this study, a new analysis strategy was developed to obtain endophytic microbiome information from plant transcriptome data. Results showed that the new strategy can obtain the composition of microbial communities and the relative content between plants and endophytic microorganisms, and between different types of endophytic microorganisms from the plant transcriptome data. Compared with the amplicon sequencing method, more endophytic microorganisms and relative content information can be obtained with the new strategy, which can greatly broaden the research scope and save the experimental cost. Furthermore, the advantages and effectiveness of the new strategy were verified with different analysis of the microbial composition, correlation analysis, inoculant content test, and repeatability test.