bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioinformatics and system biology approach to identify the influences of SARS-CoV-2 on metabolic unhealthy obese patients
Authors: Huang Tengda , Jiang Nan , Song Yujia , Pan Hongyuan , Du Ao , Yu Bingxuan , Li Xiaoquan , He Jinyi , Yuan Kefei , Wang Zhen
Published: October 2023

Introduction: The severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) has posed a significant challenge to individuals’ health. Increasing evidence shows that patients with metabolic unhealthy obesity (MUO) and COVID-19 have severer complications and higher mortality rate. However, the molecular mechanisms underlying the association between MUO and COVID-19 are poorly understood.

Methods: We sought to reveal the relationship between MUO and COVID-19 using bioinformatics and systems biology analysis approaches. Here, two datasets (GSE196822 and GSE152991) were employed to extract differentially expressed genes (DEGs) to identify common hub genes, shared pathways, transcriptional regulatory networks, gene-disease relationship and candidate drugs.

Results: Based on the identified 65 common DEGs, the complement-related pathways and neutrophil degranulation-related functions are found to be mainly affected. The hub genes, which included SPI1, CD163, C1QB, SIGLEC1, C1QA, ITGAM, CD14, FCGR1A, VSIG4 and C1QC, were identified. From the interaction network analysis, 65 transcription factors (TFs) were found to be the regulatory signals. Some infections, inflammation and liver diseases were found to be most coordinated with the hub genes. Importantly, Paricalcitol, 3,3′,4,4′,5-Pentachlorobiphenyl, PD 98059, Medroxyprogesterone acetate, Dexamethasone and Tretinoin HL60 UP have shown possibility as therapeutic agents against COVID-19 and MUO.

Conclusion: This study provides new clues and references to treat both COVID-19 and MUO.
Dysphagia and aspiration during a Parkinson's hospitalization: a care partner's perspective and recommendations for improving standards of care
Authors: Brooks Annie
Published: October 2023

People with Parkinson's disease have a significantly increased incidence and risk of aspiration pneumonia when compared to those without. Aspiration pneumonia associated with dysphagia (swallowing issues), which is the leading cause of death among people with Parkinson's disease, accounting for 25% of Parkinson's deaths. There is relatively limited evidence of the most effective strategies to balance the competing needs of each Parkinson's patient as providers aim to prevent, diagnose, and manage dysphagia. Exacerbated, and in part caused, by the intricacies of dysphagia and Parkinson's disease, there is still limited understanding among hospital providers and the Parkinson's community regarding the most appropriate measures to prevent and manage dysphagia in Parkinson's disease. The Parkinson's Foundation Hospital Care Recommendations identified the prevention and management of dysphagia as a care standard necessary to eliminate harm and attain higher reliability in care. This article discusses key components of dysphagia management in the hospital, provides a case example to demonstrate the challenges that people with PD and their care partners experience in the hospital related to dysphagia, and offers recommendations on how to better manage dysphagia and involve care partners in PD hospital care.
Puzzled by dysfunctional breathing disorder(s)? Consider the Bayesian brain hypothesis!
Authors: Peiffer Claudine
Published: October 2023

There is currently growing clinical concern regarding dysfunctional breathing disorder(s) (DBD), an umbrella term for a set of multidimensional clinical conditions that are characterized by altered breathing pattern associated with a variety of intermittent or chronic symptoms, notably dyspnea, in the absence or in excess of, organic disease. However, several aspects of DBD remain poorly understood and/or open to debate, especially the inconsistent relationship between the array of experienced symptoms and their supposedly underlying mechanisms. This may be partly due to a more general problem, i.e., the prevailing way we conceptualize symptoms. In the present article, after a brief review of the different aspects of DBD from the current perspective, I submit a call for considering DBD under the innovating perspective of the Bayesian brain hypothesis, i.e., a potent and novel model that fundamentally changes our views on symptom perception.
Short term effect of tetrahydrocurcumin on adipose angiogenesis in very high-fat diet-induced obesity mouse model
Authors: Yoysungnoen Bhornprom , Srisawat Umarat , Piyabhan Pritsana , Duansak Naphatsanan , Sookprasert Nattapon , Mathuradavong Nakorn , Poomipark Natwadee , Munkong Narongsuk , Tingpej Pholawat , Changtam Chatchawan
Published: October 2023

Tetrahydrocurcumin (THC) has been shown to possess anti-angiogenic activities. This study aims to investigate the effects of THC on adipose angiogenesis and expression of angiogenic factors that occurs in 60% high-fat diet-induced obese mice. Male ICR mice were randomly divided into 3 groups: mice fed with a low-fat diet (LFD group); mice fed with very high fat diet (VHFD group), and mice fed with VHFD supplemented with THC (300 mg/kg/day orally) (VHFD+THC treated group) for 6 weeks. Body weight (BW), food intake, fasting blood sugar (FBS), lipid profiles and visceral fats weight (VF) were measured. The microvascular density (MVD), TNF-α, VEGF, MMP-2, and MMP-9 expressions were evaluated. The VHFD group had significantly increased total cholesterol, triglyceride, food intake, BW, VF, VF/BW ratio, adipocyte size and the number of crown-liked structures as compared to LFD group. THC supplementation markedly reduced these parameters and adipocyte hypertrophy and inflammation in white adipose tissues. MVD, TNF-α, VEGF, MMP-2, and MMP-9 were over-expressed in the VHFD group. However, THC supplementation decreased MVD and reduced expression of TNF-α, VEGF, MMP-2, and MMP-9. In conclusion, THC suppressed angiogenesis in adipose tissue by the downregulation of TNF-α, VEGF, MMP-2, and MMP-9. With its effects on lipid metabolism as well as on food consumption, THC could contribute to lower visceral fat and body weight. Overall, our study demonstrated the potential benefit of THC in mitigating obesity and associated metabolic disorders along with elucidated the suppression of adipose angiogenesis as one of its underlying mechanisms.
Predicting food waste in households with children: socio-economic and food-related behavior factors
Authors: Tonini Pietro , Odina Pere Muñoz , Durany Xavier Gabarrell
Published: October 2023

Introduction

The consumption phase accounts for approximately half of the food waste generated within the food system. Numerous studies have identified families with children as the primary contributors to food waste. The aims of this paper is to enhance the comprehension of food waste behaviors in households with children by characterizing it and studying how socioeconomic characteristics and food-related behaviors can predict it.

Methods

A survey was conducted among 806 families with children, categorized by the child’s age and family structure. The study utilized descriptive statistics to summarize the food waste behaviors and binary regression to evaluate the predictive abilities of 12 variable related to the socio-economic characteristic, purchase, and preparation behaviors and diet quality factors.

Results

Perishable food items, such as fruits, vegetables, cereal-based product, and dairy products, were the primary items wasted in households with children. Two patterns of food waste were identified: inadequate food management leading to small amounts of waste in families with young and middle-aged children, and over-purchasing perishable items leading to waste in other households with children. Household type and purchasing habits were significant predictors, while the purchaser’s age and buying channel showed lower predictive capacity.

Discussion

Policies to reduce food waste should prioritize raising awareness among children, promoting good practices at the household level, and creating favorable conditions during purchases. Strategies include enlisting children’s participation in meal planning and food preparation as well as limiting the promotion of ultra-processed products and incentivizing the sale of bulk products at supermarket.
MRI for the detection of small malignant renal masses: a systematic review and meta-analysis
Authors: Shang Wenwen , Hong Guohui , Li Wei
Published: October 2023

Objective

We aimed to review the available evidence on the diagnostic performance of magnetic resonance imaging in differentiating malignant from benign small renal masses.

Methods

An electronic literature search of Web of Science, MEDLINE (Ovid and PubMed), Cochrane Library, EMBASE, and Google Scholar was performed to identify relevant articles up to 31 January 2023. We included studies that reported the diagnostic accuracy of using magnetic resonance imaging to differentiate small (≤4 cm) malignant from benign renal masses. The pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were calculated using the bivariate model and the hierarchical summary receiver operating characteristic model. The study quality evaluation was performed with the Quality Assessment of Diagnostic Accuracy Studies-2 tool.

Results

A total of 10 studies with 860 small renal masses (815 patients) were included in the current meta-analysis. The pooled sensitivity and specificity of the studies for the detection of malignant masses were 0.85 (95% CI 0.79-0.90) and 0.83 (95% CI 0.67-0.92), respectively.

Conclusions

MRI had a moderate diagnostic performance in differentiating small malignant renal masses from benign ones. Substantial heterogeneity was observed between studies for both sensitivity and specificity.
Abdominal lymph node metastasis in non-surgical esophageal squamous cell carcinoma: prognostic significance and a novel staging strategy
Authors: Zhao Zongxing , Wang Hongmin , Liu Yajing , Li Minghuan , Li Mingjun
Published: October 2023

Purpose

This study aimed to evaluate the feasibility of a combination of abdominal lymph node (LN) metastasis and the number of LNs in esophageal squamous cell carcinoma (ESCC) patients to optimize its clinical nodal staging.

Methods

A retrospective study, including a total of 707 ESCC patients treated with definitive radiotherapy, was conducted at two participating institutes. Different combinations of LN variables, including abdominal LN metastasis (R1: no-abdominal LN metastasis; R2: abdominal LN metastasis), were further analyzed to propose a potential revised nodal (rN) staging.

Results

The multivariate analyses showed that the number of metastatic LN and abdominal LN metastasis were independent prognostic factors for the overall survival (OS). The results showed no significant differences in the OS between the N2 patients with abdominal LN metastasis and N3 patients. The OS of the stage III patients with abdominal LN metastasis was not significantly different from those with stage IVa. The N3R1 and N1-2R2 had similar hazard ratios (HRs). The N1R1 subset was defined as rN1, the N2R1 subset was defined as rN2, and the N3R1-2 and N1-2R2 subsets were defined as rN3. The HRs of OS of the rN2 and rN3 groups increased subsequently. The rN stage could identify the differences in the OS times of each subgroup based on the 8th AJCC cN staging or the 11th JES N staging.

Conclusions

The rN staging, including the number of metastatic LNs and abdominal LN metastasis, might serve as a potential prognostic predictor for non-surgical patients with ESCC.
NTRK rearranged sarcoma of the bone. Role for larotrectinib in the neoadjuvant setting of an ultra-rare tumor: a case report
Authors: Palmerini Emanuela , Frega Giorgio , Gambarotti Marco , Frisoni Tommaso , Cesari Marilena , Bazzocchi Alberto , Miceli Marco , Donati Davide Maria , Fanti Stefano , Nanni Cristina , Benini Stefania , Longhi Alessandra , Paioli Anna , Marrari Andrea , Hakim Rossella , Righi Alberto , Ibrahim Toni
Published: October 2023

Background: Neurotrophic tyrosine receptor kinase (NTRK) gene-fusion targeted molecules revolutionized the paradigm of treatment of a limited subgroup of cancers of various histologies. Entrectinib and larotrectinib obtained unprecedented response rates in patients with cancer harboring NTRK rearrangements. This evidence recently led to the agnostic approval of these drugs, and evidence (confirmation) of their activity in a broader disease setting is emerging. Here, we report the case of a patient affected by EML4-NTRK3 rearranged undifferentiated spindle cell bone sarcoma treated with larotrectinib, and we argue (discuss about) the incidence and clinical presentation of NTRK gene-fusion positive bone sarcomas, the potential use of upfront treatment with NTRK inhibitors in neoadjuvant setting, and the role of a multidisciplinary tumor board. Despite the rarity of these rearrangements in patients with primitive bone sarcomas, the therapy with NTRK inhibitors represents a highly effective strategy to be pursued in selected cases even in neoadjuvant settings. The management of these very rare cancers should always be discussed in a multidisciplinary board of reference centers.
An end is in sight: a perspective on PCR as an endpoint for Chagas disease treatment trials
Authors: Hochberg Natasha S. , Rao Srinivasa P. S. , Angyalosi Gerhild , Zhao Xiaojun , Carballo Leticia , Demacq Caroline , Braud-Perez Sofia , Wieser Daniela , Casas JP , Millholland John , Ngo Debby
Published: October 2023

Novel therapies for chronic indeterminate Chagas disease (CICD) are needed, but trials are limited by the absence of tests to detect infection and early treatment efficacy. This perspective highlights the shortfalls and strengths of polymerase chain reaction (PCR) as a study endpoint for anti-parasitic drug development. Serologic reversion, the gold standard test of cure, may take decades to occur in adults and therefore is challenging as an endpoint for drug development. Use of PCR as a marker of infection and treatment response has notable limitations due to low parasitemia in CICD, fluctuations in circulating (versus tissue) parasite burden, strain differences, and assay performance. It is, however, rapidly responsive to therapy, and technological advances have improved detection of different strains and may allow for parasite quantification. Until we have more sensitive tests for parasitological clearance, PCR as a measure of treatment failure may be the best available efficacy endpoint to accelerate early development of much-needed novel therapies. Adequately designed clinical studies are needed to correlate PCR clearance with clinical outcomes and to identify novel biomarkers predictive of clinical outcomes in patients with CICD. Public-private partnerships and health authority engagement are paramount to identify feasible trial endpoints and deliver promising new drug candidates for Chagas disease.
Respiratory patterns in spontaneously breathing near-term lambs delivered by caesarean section under spinal anaesthesia
Authors: Davies I. M. , Crossley K. J. , McGillick E. V. , Nitsos I. , Rodgers K. , Thiel A. , Zahra V. A. , te Pas A. B. , Hooper S. B.
Published: October 2023

Introduction

The transition to newborn life has typically been studied in intubated and mechanically ventilated newborn lambs delivered via caesarean section (CS) under general anaesthesia. As a result, little is known of the spontaneous breathing patterns in lambs at birth, particularly those at risk of developing respiratory distress (RD). We have developed a method for delivering spontaneously breathing near-term lambs to characterise their breathing patterns in the immediate newborn period.

Methods

At 137–8 days gestation (2–3 days prior to delivery; term ∼147 days), fetal lambs (n = 7) were partially exteriorised for instrumentation (insertion of catheters and flow probes) before they were returned to the uterus. At 140 days, lambs were delivered via CS under light maternal sedation and spinal anaesthesia. Lambs were physically stimulated and when continuous breathing was established, the umbilical cord was clamped. Breathing patterns were assessed by measuring intrapleural and upper-tracheal pressures during the first four hours after birth.

Results

Newborn lambs display significant heterogeneity in respiratory patterns in the immediate newborn period that change with time after birth. Seven distinct breathing patterns were identified including: (i) quiet (tidal) breathing, (ii) breathing during active periods, (iii) breathing during oral feeding, (iv) tachypnoea, (v) expiratory braking manoeuvres, (vi) expiratory pauses or holding, and (vii) step changes in ventilation.

Conclusions

We have described normal respiratory behaviour in newborn lambs, in order to identify respiratory behaviours that are indicative of RD in term newborn infants.
Greater numbers and sizes of muscle bundles in the breast and leg muscles of broilers compared to layer chickens
Authors: Lee Boin , Kim Dong-Hwan , Lee Joonbum , Cressman Michael D. , Choi Young Min , Lee Kichoon
Published: October 2023

Meat-type (broiler) and egg-type (layer) chickens were bred by intensive selection over the years, resulting in more numbers and larger sizes of myofibers. Although the characteristics are important parameters in muscle growth and meat quality, muscle bundle characteristics have not been studied in poultry. Therefore, this study aimed to compare the histological characteristics of myofibers and muscle bundles in muscles between male broiler (Ross broiler breed) chickens and layer (Hy-Line) chickens. Chicken muscles, pectoralis major (PM) and gastrocnemius (GM), were sampled at the age of 49 days and stained to analyze histological characteristics. Expectedly, body weights (BWs) and weights of PM and GM muscles in 49-day-old broilers were significantly heavier than those in layers. Within PM, broilers exhibited greater number and cross-sectional area (CSA) of myofibers than layers (3.3- and 3.3-fold, respectively). The total number and CSA of PM muscle bundles were approximately 1.5 and 6.6 times greater, respectively, in broilers than layers. Moreover, broilers exhibited 2 times greater number of myofibers per bundle of PM muscle than layers. Within GM, myofiber number and CSA were 2.3- and 2.4-fold greater, respectively, in broilers than layers. In addition, the total number of muscle bundles and bundle CSA were 2.5- and 2.1-fold greater, respectively, in broilers than in the layers. The novel findings of the current study provide evidence that greater muscle mass of broilers occurs by both hyperplasia and hypertrophy of muscle bundles and myofibers.
Analysis of gaps in rapeseed (Brassica napus L.) collections in European genebanks
Authors: Weise Stephan , Hoekstra Roel , Kutschan Kim Jana , Oppermann Markus , van Treuren Rob , Lohwasser Ulrike
Published: October 2023

Rapeseed is one of the most important agricultural crops and is used in many ways. Due to the advancing climate crisis, the yield potential of rapeseed is increasingly impaired. In addition to changing environmental conditions, the expansion of cultivated areas also favours the infestation of rapeseed with various pests and pathogens. This results in the need for continuous further development of rapeseed varieties. To this end, the potential of the rapeseed gene pool should be exploited, as the various species included in it contain promising resistance alleles against pests and pathogens. In general, the biodiversity of crops and their wild relatives is increasingly endangered. In order to conserve them and to provide impulses for breeding activities as well, strategies for the conservation of plant genetic resources are necessary. In this study, we investigated to what extent the different species of the rapeseed gene pool are conserved in European genebanks and what gaps exist. In addition, a niche modelling approach was used to investigate how the natural distribution ranges of these species are expected to change by the end of the century, assuming different climate change scenarios. It was found that most species of the rapeseed gene pool are significantly underrepresented in European genebanks, especially regarding representation of the natural distribution areas. The situation is exacerbated by the fact that the natural distributions are expected to change, in some cases significantly, as a result of ongoing climate change. It is therefore necessary to further develop strategies to prevent the loss of wild relatives of rapeseed. Based on the results of the study, as a first step we have proposed a priority list of species that should be targeted for collecting in order to conserve the biodiversity of the rapeseed gene pool in the long term.
Effects of gamma radiation on engineered tomato biofortified for space agriculture by morphometry and fluorescence-based indices
Authors: Pagliarello Riccardo , Bennici Elisabetta , Di Sarcina Ilaria , Villani Maria Elena , Desiderio Angiola , Nardi Luca , Benvenuto Eugenio , Cemmi Alessia , Massa Silvia
Published: October 2023

Introduction

Future long-term space missions will focus to the solar system exploration, with the Moon and Mars as leading goals. Plant cultivation will provide fresh food as a healthy supplement to astronauts’ diet in confined and unhealthy outposts. Ionizing radiation (IR) are a main hazard in outer space for their capacity to generate oxidative stress and DNA damage. IR is a crucial issue not only for human survival, but also for plant development and related value-added fresh food harvest. To this end, efforts to figure out how biofortification of plants with antioxidant metabolites (such as anthocyanins) may contribute to improve their performances in space outposts are needed.

Methods

MicroTom plants genetically engineered to express the Petunia hybrida PhAN4 gene, restoring the biosynthesis of anthocyanins in tomato, were used. Seeds and plants from wild type and engineered lines AN4-M and AN4-P2 were exposed to IR doses that they may experience during a long-term space mission, simulated through the administration of gamma radiation. Plant response was continuously evaluated along life cycle by a non-disturbing/non-destructive monitoring of biometric and multiparametric fluorescence-based indices at both phenotypic and phenological levels, and indirectly measuring changes occurring at the primary and secondary metabolism level.

Results

Responses to gamma radiation were influenced by the phenological stage, dose and genotype. Wild type and engineered plants did not complete a seed-to-seed cycle under the exceptional condition of 30 Gy absorbed dose, but were able to cope with 0.5 and 5 Gy producing fruits and vital seeds. In particular, the AN4-M seeds and plants showed advantages over wild type: negligible variation of fluorimetric parameters related to primary metabolism, no alteration or improvement of yield traits at maturity while maintaining smaller habitus than wild type, biosynthesis of anthocyanins and maintained levels of these compounds compared to non-irradiated controls of the same age.

Discussion

These findings may be useful in understanding phenotypic effects of IR on plant growth in space, and lead to the exploitation of new breeding efforts to optimize plant performances to develop appropriate ideotypes for future long-term space exploration extending the potential of plants to serve as high-value product source.
Examining the effectiveness of gamification as a tool promoting teaching and learning in educational settings: a meta-analysis
Authors: Li Minzi , Ma Siyu , Shi Yuyang
Published: October 2023

The integration of gamification into educational settings has gained recognition for its potential to boost student motivation, engagement, interest, and learning outcomes. Despite its popularity, research on gamification has produced mixed results regarding student learning outcomes. This meta-analysis aims to synthesize the existing empirical evidence on the effectiveness of gamification as a tool for promoting teaching and learning in educational settings. Forty-one studies with 49 independent samples involving more than 5,071 participants were included in our analysis. Results from random effects models showed an overall significant large effect size (g = 0.822 [0.567 to 1.078]). The research performed the moderator analysis to scrutinize the effects of a number of factors on the relationship between gamification and student learning outcomes. The study uncovered significant moderating effects for user type, educational discipline, design principles for educational gamification, duration of “gameful” experience, and learning environment. However, measurement of student outcomes and publication type did not appear to have any significant moderating effect. Those findings hold important implications for improving and implementing gamification to promote teaching and learning in future research.
Psychological and environmental factors influencing resilience among Ukrainian refugees and internally displaced persons: a systematic review of coping strategies and risk and protective factors
Authors: Rizzi Damiano , Ciuffo Giulia , Landoni Marta , Mangiagalli Matteo , Ionio Chiara
Published: October 2023

Background

There is much discussion in the literature about the link between traumatic events related to war and mental illness. However, in comparison, mental health has been more researched than protective factors such as coping methods, which are the primary factors to build resilience in these circumstances. This review examines the psychological and environmental elements that influence the resilience of Ukrainian refugees and IDPs by analyzing coping strategies and risk and protective factors.

Methods

A literature search was conducted on PsycINFO, Pubmed, Scopus, and Science Direct, with 259 articles screened and 13 determined as eligible for inclusion. Inclusion criteria were: (1) studies on adult Ukrainian refugees and/or IDPs; (2) original, peer-reviewed studies; and (3) studies written in English or Italian language. Single-case reports and qualitative studies were excluded, as well as those studies written in any other language, and any studies for which the full-text version could not be obtained (i.e., conference abstracts). Two reviewers independently reviewed titles and abstracts, reviewed relevant articles’ full text, and extracted the data.

Results

A diverse range of individual and socio-environmental risk and protective factors were identified, influencing the resilience of Ukrainian refugees and IDPs, as well as five main categories of coping strategies: emotion-focused strategies, problem-focused strategies, avoidance, faith-based strategies, and the ones based on sense of belonging.

Discussion

War trauma and associated stressors can lead to distressing physical and psychological reactions, which persist even after leaving the war zone. Many individual and socio-environmental risk factors, such as mental disorders, financial security, having relatives wounded or displaced, and an unfamiliar environment could influence the risk and severity of psychological difficulties, emphasizing the importance of coping strategies, social connections, faith, and cultural resilience.

Conclusion

This systematic review underscores the complex range of coping strategies and factors influencing the resilience of Ukrainian refugees and IDPs. Social connections and inclusive community interventions play vital roles in improving their psychological well-being, while longitudinal studies and culturally sensitive support are needed to address their unique challenges and strengths. Implementing collaborative care models can provide comprehensive support by integrating mental health services with primary healthcare and community-based organizations.
Inflammatory markers in outpatients with schizophrenia diagnosis in regular use of clozapine: a cross-sectional study
Authors: Cordova Victor Hugo Schaly , Teixeira Amelia Dias , Anzolin Ana Paula , Moschetta Roberta , Belmonte-de-Abreu Paulo Silva
Published: October 2023

It is known that inflammation worsen the course of schizophrenia and induce high clozapine serum levels. However, no study evaluated this change in function of clozapine daily dose in schizophrenia. We assessed the correlation between inflammation and severity symptoms in patients with schizophrenia that take and do not take clozapine. We also assessed the correlation between clozapine daily dose and inflammatory markers to patients who take this drug. Patients were recruited from Schizophrenia Ambulatory and Psychosocial Care Center of Clinical Hospital of Porto Alegre and from an association of relatives of patients with schizophrenia. Exam results, and other important clinical exam were assessed in patients record or patients were asked to show their exam in the case of outpatients. We included 104 patients, 90 clozapine users and 14 non-clozapine users. We calculate the systemic inflammatory markers [neutrophil-lymphocyte ratio (NLR), systemic immune inflammation index (SII), and the psychopathology severity by the Brief Psychiatric Rating Scaled anchored (BPRS-a)]. These variables were compared between clozapine users and non-clozapine users. It was used mean/median test according to data distributing, with study factor (SII, MLR, and PLR), the clinical outcome: severity of symptomatology (BPRS score), and clozapine daily dose as adjustment factor. Clozapine users exhibited a significantly higher neutrophil count (mean ± SD: 5.03 ± 2.07) compared to non-clozapine users (mean ± SD: 3.48 ± 1.27; p = 0.031). After controlling for comorbidity, other parameters also showed significant differences. These findings are consistent with previous studies that have demonstrated an inflammatory response following the administration of clozapine.
On the momentum toward vaccine self-sufficiency in the BRICS: an integrative review of the role of pharmaceutical entrepreneurship and innovation
Authors: Zhang Yongqiang , Li Hongbo , Xu Xinglong , Antwi Henry Asante
Published: October 2023

Background

With the perspicuous effect of COVID-19 on vaccine demand, academic and business interest in vaccine production in the BRICS nations (Brazil, the Russian Federation, India, China, and South Africa) has reached a crescendo. Aware of a “dark” past when the BRICS depended heavily on vaccines and pharmaceuticals from other parts of the world, academic curiosity on how the BRICS countries have leveraged vaccine self-sufficiency and become the hub of global vaccine production and supply is justifiable, especially in times of ineffable pandemics.

Methods

The articles were searched from November 2020 to December 2022. Within this period, an electronic search of 13 reputable healthcare and public databases was conducted. The initial searches from the designated databases yielded a total of 3,928 articles. Then, duplicated studies were removed through a two-step process, articles without titles and abstracts were excluded, and the remaining 898 articles that met the qualification assessment criteria were evaluated for article quality.

Results

The main entrepreneurial innovations that have quickened the pace of vaccine self-sufficiency in the BRICS include investment in artificial intelligence (AI), Big Data Analytics, and Blockchain technologies. These help to speed up the drug delivery process by enhancing patient identification or optimizing potential drug candidates for clinical trials and production.

Conclusion

Over the past 20 years, the BRICS nations have achieved major strides in vaccine development, regulation, and production. The creation of the BRICS Vaccine Research and Development (R&D) Center will have a significant impact on vaccine cost and accessibility given the anticipated development of stronger research capability, production, and distribution technology, as well as stronger standardization to improve vaccine production quality in the near future. It is anticipated that the BRICS’ contributions to vaccine development will alter the global vaccination market and hasten the availability of vaccinations in developing nations. The challenge is turning these hopes into concrete plans of action and outcomes.
Living arrangements, health lifestyles, and health outcomes among Chinese oldest-old
Authors: Wang Jie , Zhang Lanxi , Wang Shen , Zhang Li
Published: October 2023

Background

Prior literature has documented a strong correlation between living arrangements and older adults' health outcomes. However, few studies have explained why this association exists. This study took the health lifestyle theory approach and brought health lifestyles into the link between living arrangements and Chinese oldest-old health outcomes. It examined (1) whether healthy lifestyle behaviors among the oldest-old varied by household contexts and (2) whether the health disparities among the Chinese oldest-old in different household contexts could be partially explained by their healthy lifestyles.

Methods

Using the most recent 2018 data released by the Chinese Longitudinal Healthy Longevity Survey (CLHLS), latent class analysis was applied to identify predominant health lifestyles among the Chinese oldest-old aged 85-105 years. Regression analyses were used to test the mediating effect of health lifestyles.

Results

Three distinct classes representing the health lifestyles of Chinese oldest-old emerged; health lifestyle patterns were found to vary by elders' living arrangements. The respondent's health lifestyles in diverse residential structures served as a mediator which can partially explain the health disparities among the oldest-old.

Conclusion

The results suggested that health lifestyles can serve as a mediator to explain the association between oldest-old living arrangement patterns and their health outcomes. The findings highlighted the importance of family, lifestyles, and cultural contexts to the health of the oldest-old.
Self-care interventions of community-dwelling older adults: a systematic review and meta-analysis
Authors: González-González Estela , Requena Carmen
Published: October 2023

Introduction

The current notion of “care in old age” should be reconceptualized in the ageing societies of the 21st century. Currently, “being old” means that one is actively involved in their care and has the desire to retain control and independence.

Objective

Understand and analyze the efficacy of interventions in the physical and psychological self-care practices of healthy community-dwelling older people.

Methodology

Systematic review and meta-analysis. The guidelines of the PRISMA guide were followed. The methodological quality of the studies was checked using Cochrane Effective Practice and Organisation of Care criteria, and the search was performed between 2016 and 2021.

Results

Of the 1,866 evaluated, 8 studies met the criteria. The systematic review reveals that self-care interventions focus on physical health-related variables but not on psychological variables. The meta-analysis shows that interventions significantly improve physical health-related variables (care visits, hospital admission, medication, and gait speed).

Conclusion

Self-care training programs should include psychological variables to increase health and well-being in healthy older people.
Association between daily use of social media and behavioral lifestyles in the Saudi community: a cross-sectional study
Authors: BinDhim Nasser F. , Althumiri Nora A. , Al-Duraihem Rashed Abdullah , Alasmary Saeed , Alkhamaali Zaied , Alhabeeb Abdulhameed Abdullah
Published: October 2023

Objective

This study aimed to investigate the association between nine social media platforms use and health-related behavior, including fruit and vegetable intake, physical activity, tobacco use, and risk factors including depression and obesity.

Methods

A cross-sectional study was conducted using secondary data from the Sharik Health Indicators Surveillance System (SHISS). Participants 18 years and older were recruited via phone-interviews. The nine social media platform use [Twitter-(X), Facebook, Instagram, WhatsApp, LinkedIn, Snapchat, TikTok, Telegram, and YouTube] were assessed using self-reported use. Health-related variables include behavioral factors including diet, physical activity, and tobacco use including (cigarettes, waterpipes, and e-cigarettes), risk of depression and obesity. Logistic regression analysis was performed to explore the association between social media use and health-related variables.

Results

The study indicated that daily Snapchat users had a lower healthy diet (fruit and vegetable intake), whereas daily LinkedIn and WhatsApp users were positively associated with a healthier diet, relative to those with infrequent social media use. Furthermore, daily interaction with Instagram, TikTok, Telegram, and YouTube was significantly associated with increased depression risk. Conversely, Snapchat and WhatsApp usage was significantly linked to a decreased depression risk. Tobacco-smoking behaviors were associated with specific social media platforms: cigarette smoking was associated with Snapchat, TikTok, and YouTube; e-cigarette with Facebook, LinkedIn, Snapchat, and TikTok; and waterpipe smoking with Facebook and TikTok. Interestingly, some platforms, such as Instagram, were associated with reduced cigarette smoking. The relationship between social media activity and health-related outcomes remained significant after adjusting for age and gender.

Conclusion

This study highlights the potential negative impact of particular daily social media use on health-related variables, including dietary habits, tobacco use, and depression. Nevertheless, particular daily social media use of some platforms was associated with a potential positive impact on the health-related variables. Social media platforms are tools that can be used to achieve both a positive and negative effect. By knowing which demographic segments have a greater presence on one platform, we are creating opportunities to understand the social phenomena and at the same time use it to reach those segments and communicate with them, because each social media platform has its unique way and framework of user communication.
How can quantitative policy analysis inform the energy transition? The case of electrification
Authors: Vaishnav Parth
Published: October 2023

Quantitative analyses may aim to provide actionable answers to policy questions and to generate tools or insights for decision-making. Given the deep uncertainties involved in any realistic reckoning of policy questions, this study argues that only the second of these goals is achievable. Here, this argument is illustrated by considering analyses of how the electrification of an activity changes the damage from the air pollution emissions that occur because of that activity. The sources of uncertainty in such an analysis include the long life of the technologies being studied. Consequently, the structure and operation of the electricity grid might change because of the new technology and independent of it. Analysts must make subjective choices about what to include in their analysis and what to exclude. For example, policies modeled in isolation may, in reality, be bundled with other policies; interactions between technologies may be missed if the analysis focuses on only one technology; and certain benefits or costs may be neglected because they lie outside the scope of the analysis and the expertise of the analyst. Quantitative policy analysis must aim to be part of the broader discussions in society that ultimately determine what policies get implemented.
Computation of the Hausdorff Distance between Two Compact Convex Sets
Authors: Lange Kenneth
Published: October 2023

The Hausdorff distance between two closed sets has important theoretical and practical applications. Yet apart from finite point clouds, there appear to be no generic algorithms for computing this quantity. Because many infinite sets are defined by algebraic equalities and inequalities, this a huge gap. The current paper constructs Frank–Wolfe and projected gradient ascent algorithms for computing the Hausdorff distance between two compact convex sets. Although these algorithms are guaranteed to go uphill, they can become trapped by local maxima. To avoid this defect, we investigate a homotopy method that gradually deforms two balls into the two target sets. The Frank–Wolfe and projected gradient algorithms are tested on two pairs (A,B) of compact convex sets, where: (1) A is the box [−1,1] translated by 1 and B is the intersection of the unit ball and the non-negative orthant; and (2) A is the probability simplex and B is the ℓ1 unit ball translated by 1. For problem (2), we find the Hausdorff distance analytically. Projected gradient ascent is more reliable than the Frank–Wolfe algorithm and finds the exact solution of problem (2). Homotopy improves the performance of both algorithms when the exact solution is unknown or unattained.
Multiprocessor Fair Scheduling Based on an Improved Slime Mold Algorithm
Authors: Dai Manli , Jiang Zhongyi
Published: October 2023

An improved slime mold algorithm (IMSMA) is presented in this paper for a multiprocessor multitask fair scheduling problem, which aims to reduce the average processing time. An initial population strategy based on Bernoulli mapping reverse learning is proposed for the slime mold algorithm. A Cauchy mutation strategy is employed to escape local optima, and the boundary-check mechanism of the slime mold swarm is optimized. The boundary conditions of the slime mold population are transformed into nonlinear, dynamically changing boundaries. This adjustment strengthens the slime mold algorithm’s global search capabilities in early iterations and strengthens its local search capability in later iterations, which accelerates the algorithm’s convergence speed. Two unimodal and two multimodal test functions from the CEC2019 benchmark are chosen for comparative experiments. The experiment results show the algorithm’s robust convergence and its capacity to escape local optima. The improved slime mold algorithm is applied to the multiprocessor fair scheduling problem to reduce the average execution time on each processor. Numerical experiments showed that the IMSMA performs better than other algorithms in terms of precision and convergence effectiveness.
Emerging 6G/B6G Wireless Communication for the Power Infrastructure in Smart Cities: Innovations, Challenges, and Future Perspectives
Authors: Al Amin Ahmed , Hong Junho , Bui Van-Hai , Su Wencong
Published: October 2023

A well-functioning smart grid is an essential part of an efficient and uninterrupted power supply for the key enablers of smart cities. To effectively manage the operations of a smart grid, there is an essential requirement for a seamless wireless communication system that provides high data rates, reliability, flexibility, massive connectivity, low latency, security, and adaptability to changing needs. A contemporary review of the utilization of emerging 6G wireless communication for the major applications of smart grids, especially in terms of massive connectivity and monitoring, secured communication for operation and resource management, and time-critical operations, are presented in this paper. This article starts with the key enablers of the smart city, along with the necessity of the smart grid for the key enablers of it. The fundamentals of the smart city, smart grid, and 6G wireless communication are also introduced in this paper. Moreover, the motivations to integrate 6G wireless communication with the smart grid system are expressed in this article as well. The relevant literature overview, along with the novelty of this paper, is depicted to bridge the gap of the current research works. We describe the novel technologies of 6G wireless communication to effectively perform the considered smart grid applications. Novel technologies of 6G wireless communication have significantly improved the key performance indicators compared to the prior generation of the wireless communication system. A significant part of this article is the contemporary survey of the considered major applications of a smart grid that is served by 6G. In addition, the anticipated challenges and interesting future research pathways are also discussed explicitly in this article. This article serves as a valuable resource for understanding the potential of 6G wireless communication in advancing smart grid applications and addressing emerging challenges.
Vibration Response of Soil under Low-Frequency Vibration Using the Discrete Element Method
Authors: Wan Lipengcheng , Li Yonglei , Song Jinyu , Ma Xiang , Dong Xiangqian , Zhang Chao , Song Jiannong
Published: October 2023

The vibration response of soil is a key property in the field of agricultural soil tillage. Vibration components of tillage machinery are generally used to reduce tillage resistance and improve work efficiency, and the pressure variation under low-frequency vibration will affect the fragmentation and dispersion of farmland soil. However, the gradient of pressure variation, frequency domain response, and effective transmission range is unclear. A new method based on the DEM (discrete element method) is presented to study the vibration response and pressure transmission under low-frequency vibration. Bench test results have shown that peak pressure positively correlates with the vibration frequency and attenuates rapidly at a vibration distance of 100 to 250 mm. The resulting data were also selected to determine the simulation model’s parameters. Amplitude, vibration frequency, and soil depth were used as test factors in single-factor simulation tests, and their effects on the peak pressure, frequency domain response, and effective transmission distance were analyzed. The results showed a positive relationship between the peak pressure and the test factors. The peak pressure increased with a maximum gradient of 19.02 kPa/mm at a vibration distance of 50 mm. The amplitude, vibration frequency, and soil depth positively correlated with the dominant frequency amplitude. The main frequency was independent of amplitude and soil depth. At a vibration distance of 250 mm, the dominant frequency was approximately twice the vibration frequency at 7–11 Hz and approximately equal to the vibration frequency at 13–15 Hz. Multiple exponential functions were used to fit the peak pressure attenuation function, obtaining an effective transmission distance range of 347.15 to 550.37 mm for the 5 kPa cut-off pressure. For a soil depth of 300 mm, the vertical shear wave diffusion angle was greater than the horizontal shear wave diffusion angle. This study clarifies the vibration response of soil under low-frequency vibration, which helps to design vibration-type, soil-engaging components of tillage machinery and match vibration parameters for energy-saving and resistance reduction purposes in soil tillage.
The Digital Economy, Green Technology Innovation, and Agricultural Green Total Factor Productivity
Authors: Chen Yunsi , Hu Sumin , Wu Haoqiang
Published: October 2023

The digital economy is a key driver of greener agriculture and sustainable development. This paper focuses on the impact of the digital economy on green agricultural development and the mediating role of green technology innovation. Using provincial panel data from China from 2011 to 2020, we test hypotheses using fixed effects models. The results indicate that: (a) the digital economy boosts agricultural total factor productivity (AGTFP); (b) green technology innovation positively moderates the relationship between the digital economy and AGTFP; and (c) the positive impact of the digital economy on green agriculture varies across regions, favoring eastern areas.