bluuebunny/crossref_metadata_2025 huggingface dataset:
Market Access and Agricultural Diversification: An Analysis of Brazilian Municipalities
Authors: Perosa Bruno Benzaquen , Bicudo da Silva Ramon Felipe , Batistella Mateus
Published: January 2024

Market access has a deep impact on farmers’ decisions, influencing their choice of crops and technology adoption. Crop diversification depends on the availability of markets to trade the agricultural portfolio. This study explored how market access impacted the level of diversification in 5565 Brazilian municipalities from 2013 to 2021. We developed a regression model considering how variables related to market access and commercialization (storage, roads, distribution centers, commercialization credit, among others) affected a local (municipality level) diversification index. After environmental variables were controlled, the results indicated that most of the market access variables have a significant impact on diversification. We also used map analysis to analyze the regional patterns of specialization in Brazilian agriculture, concluding that logistics and commercialization infrastructure have strong influence on the level of diversification in Brazil, a major agricultural powerhouse in the world. The results indicate that market access variables affect diversification and should be considered by policy makers aiming to increase sustainability in agriculture and livestock.
Effect of Grease Viscosity on Channeling Properties of Ball Bearings
Authors: Obata Tomohiko , Fujiwara Hiroki , Itoigawa Fumihiro , Maegawa Satoru
Published: January 2024

Grease-lubricated rolling bearings transition from the churning phase to the channeling phase. This transition property affects grease life and torque properties. Therefore, the relationship between grease yield stress and grease degradation during operation, which affects this transition, has been investigated. However, there have been few studies on grease flow that affects the transition. In this study, the mechanism of grease reduction on the races was investigated for small bearings operated at low speeds, where thermal degradation and softening of the grease are less likely to occur. It was inferred that the grease transfer to the cage affects the channeling transition and that the amount of transfer varies depending on the initial grease viscosity. These findings can be applied to grease composition and cage design and are useful in providing bearings with excellent low-torque characteristics, such as in industrial motor applications.
Antimicrobial Activity of Morphology-Controlled Cu2O Nanoparticles: Oxidation Stability under Humid and Thermal Conditions
Authors: Park Jeong Yeon , Lee Siwoo , Kim Yangdo , Ryu Young Bok
Published: January 2024

Metal oxides can be used as antimicrobial agents, especially since they can be fabricated into various forms such as films, masks, and filters. In particular, the durability of antimicrobial agents and the duration of their antimicrobial activity are important factors that determine their suitability for a specific purpose. These factors are related to the morphology and size of particles. The metal oxide Cu2O is often oxidized to CuO in various conditions, which reduces its antimicrobial activity. This study focused on the oxidation of nanoparticles of Cu2O with three morphologies, namely, spherical, octahedral, and cubic morphologies, in excessively humid and excessive-thermal environments for a specific duration and the antimicrobial activity of the NPs. Cu2O nanoparticles were prepared using the chemical reduction method, and their morphology could be varied by adjusting the molar ratio of OH− to Cu2+ and changing the reducing agent. It was found that cubic Cu2O was the most stable against oxidation and had the smallest reduction in antimicrobial activity. This study examined the antimicrobial activity and the oxidation stability of Cu2O NPs with different morphologies but similar particle sizes.
Fracture Resistance of Posterior Tooth-Supported Cantilever Fixed Dental Prostheses of Different Zirconia Generations and Framework Thicknesses: An In Vitro Study
Authors: Klotz Anna-Luisa , Halfmann Janina , Rues Stefan , Bömicke Wolfgang , Rammelsberg Peter , Zenthöfer Andreas
Published: January 2024

The rehabilitation of free-end situations is a frequent indication in prosthetic dentistry. Cantilever fixed dental prostheses (cFDPs) made of 1st and 2nd generation zirconia are one treatment option. Due to a unique gradient technology, combinations of different zirconium dioxide generations are thus feasible in one restoration. However, data about these materials are rare. The purpose of this study was therefore to investigate the fracture resistance and fracture modes of tooth-supported cFDPs fabricated from different zirconia materials (gradient technology) and different framework thicknesses. A total of 40 cFDPs were fabricated using the CAD/CAM approach and belonged to five test groups. The different groups differed in the yttria content, the proportion of the tetragonal/cubic phases, or in wall thickness (0.7 mm or 1 mm). After completion, the cFDPs were subjected to thermal cycling and chewing simulation (1.2 × 106 load cycles, 108 N load). Afterwards, cFDPs were statically loaded until fracture in a universal testing machine. A non-parametric ANOVA was compiled to determine the possible effects of group membership on fracture resistance. In addition, post-hoc Tukey tests were used for bivariate comparisons. The mean fracture loads under axial load application ranged from 288 to 577 N. ANOVA detected a significant impact of the used material on the fracture resistances (p < 0.001). Therefore, the use of cFDPs fabricated by gradient technology zirconia may not be unreservedly recommended for clinical use, whereas cFPDs made from 3Y-TZP exhibit fracture resistance above possible masticatory loads in the posterior region.
Microstructure and Wear Resistance of Ti6Al4V Titanium Alloy Laser-Clad Ni60/WC Composite Coating
Authors: Feng Mingjia , Ma Yunhai , Tian Yitong , Cao Hongtu
Published: January 2024

In this paper, Ni60/WC wear-resistant coatings have been created on the Ti6Al4V substrate surface using a pre-layered powder laser cladding method by deploying various scanning speeds of 8, 10, 12, and 14 mm/s. The coatings are characterized through X-ray diffraction (XRD), scanning electron microscopy (SEM), and a high-speed reciprocating fatigue wear tester. It is found that the phase composition of the coating comprises the synthesized, hard phase TiC and TiB2, the silicides WSi2 and W5Si3, and NiTi and γ-Ni solid solutions. At different scanning speeds, there is a metallurgical fusion line in the bonding area of the fused cladding layer, indicating a good metallurgical bonding between the substrate and the powder. At a low scanning speed, the coating develops into coarse dendrites, which shows significant improvement with scanning speed. The microhardness first increases and then decreases with the scanning speed, and the coating’s average microhardness was 2.75–3.13 times higher than that of the substrate. The amount of mass wear has been reduced by 60.1–79.7% compared to the substrate. The wear behavior of the coatings was studied through detailed analysis of wear surfaces’ microstructures and the amount of wear to identify the optimum scanning speed.
Enhanced Degradation of Ethylene in Thermo-Photocatalytic Process Using TiO2/Nickel Foam
Authors: Trzeciak Maciej , Miądlicki Piotr , Tryba Beata
Published: January 2024

The photocatalytic decomposition of ethylene was performed under UV-LED irradiation in the presence of nanocrystalline TiO2 (anatase, 15 nm) supported on porous nickel foam. The process was conducted in a high-temperature chamber with regulated temperature from ambient to 125 °C, under a flow of reacted gas (ethylene in synthetic air, 50 ppm, flow rate of 20 mL/min), with simultaneous FTIR measurements of the sample surface. Ethylene was decomposed with a higher efficiency at elevated temperatures, with a maximum of 28% at 100–125 °C. The nickel foam used as support for TiO2 enhanced ethylene decomposition at a temperature of 50 °C. However, at 50 °C, the stability of ethylene decomposition was not maintained in the following reaction run, but it was at 100 °C. Photocatalytic measurements conducted in the presence of certain radical scavengers indicated that a higher efficiency of ethylene decomposition was obtained due to the improved separation of charge carriers and the increased formation of superoxide anionic radicals, which were formed at the interface of the thermally activated nickel foam and TiO2.
The Microstructural Evolution and Corrosion Behavior of Zn-Mg Alloys and Hybrids Processed Using High-Pressure Torsion
Authors: Tanji Ayoub , Hermawan Hendra , Boehlert Carl J.
Published: January 2024

Zinc (Zn) alloys, particularly those incorporating magnesium (Mg), have been explored as potential bioabsorbable metals. However, there is a continued need to enhance the corrosion characteristics of Zn-Mg alloys to fulfill the requirements for biodegradable implants. This work involves a corrosion behavior comparison between severe-plastic-deformation (SPD) processed cast Zn-Mg alloys and their hybrid counterparts, having equivalent nominal compositions. The SPD processing technique used was high-pressure torsion (HPT), and the corrosion behavior was studied as a function of the number of turns (1, 5, 15) for the Zn-3Mg (wt.%) alloy and hybrid and as a function of composition (Mg contents of 3, 10, 30 wt.%) for the hybrid after 15 turns. The results indicated that HPT led to multimodal grain size distributions of ultrafine Mg-rich grains containing MgZn2 and Mg2Zn11 nanoscale intermetallics in a matrix of coarser dislocation-free Zn-rich grains. A greater number of turns resulted in greater corrosion resistance because of the formation of the intermetallic phases. The HPT hybrid was more corrosion resistant than its alloy counterpart because it tended to form the intermetallics more readily than the alloy due to the inhomogeneous conditions of the materials before the HPT processing as well as the non-equilibrium conditions imposed during the HPT processing. The HPT hybrids with greater Mg contents were less corrosion resistant because the addition of Mg led to less noble behavior.
Shear Waves in an Elastic Plate with a Hole Resting on a Rough Base
Authors: Filippov Anatoly Nikolaevich
Published: January 2024

The article is devoted to the analytical and numerical study of the pattern of propagation and attenuation, due to Coulomb friction, of shear waves in an infinite elastic thin plate with a circular orifice of radius r0 lying on a rough base. Considering the friction forces and their influence on the sample of wave propagation in extended rods or thin plates is important for calculating the stress–strain state in them and the size of the area of motion. An exact analytical solution of a nonlinear boundary value problem for tangential stresses and velocities is obtained in quadratures by the Laplace transform, with respect to time. It turned out that the complete exhaustion of the wave front of a strong rupture occurs at a finite distance r* from the center of the orifice, and an elementary formula is given for this distance (the case of tangential shock stresses suddenly applied to the orifice boundary is considered). For various ratios of the magnitude of the limiting friction force to the amplitude of the applied load, the stopping (trailing) wave fronts are calculated. After passing them, a state of static equilibrium between the elastic and friction forces with a nonlinear distribution of residual stresses is established in the region r0≤r≤r*. For the first time, a precise analytical solution was obtained for the boundary value problem of the propagation of elastic shear waves in an infinite isotropic space with a cylindrical cavity, when a tangential shock load is set on its surface.
Comparative Genome Analyses Provide Insight into the Antimicrobial Activity of Endophytic Burkholderia
Authors: Jia Jiayuan , Lu Shi-En
Published: January 2024

Endophytic bacteria are endosymbionts that colonize a portion of plants without harming the plant for at least a part of its life cycle. Bacterial endophytes play an essential role in promoting plant growth using multiple mechanisms. The genus Burkholderia is an important member among endophytes and encompasses bacterial species with high genetic versatility and adaptability. In this study, the endophytic characteristics of Burkholderia species are investigated via comparative genomic analyses of several endophytic Burkholderia strains with pathogenic Burkholderia strains. A group of bacterial genes was identified and predicted as the putative endophytic behavior genes of Burkholderia. Multiple antimicrobial biosynthesis genes were observed in these endophytic bacteria; however, certain important pathogenic and virulence genes were absent. The majority of resistome genes were distributed relatively evenly among the endophytic and pathogenic bacteria. All known types of secretion systems were found in the studied bacteria. This includes T3SS and T4SS, which were previously thought to be disproportionately represented in endophytes. Additionally, questionable CRISPR-Cas systems with an orphan CRISPR array were prevalent, suggesting that intact CRISPR-Cas systems may not exist in symbiotes of Burkholderia. This research not only sheds light on the antimicrobial activities that contribute to biocontrol but also expands our understanding of genomic variations in Burkholderia’s endophytic and pathogenic bacteria.
The Crayfish Plague Pathogen Aphanomyces astaci in Ireland
Authors: Brady Daniel J. , Meade Rossa , Reynolds Julian D. , Vilcinskas Andreas , Theissinger Kathrin
Published: January 2024

Crayfish plague is a devastating disease of European freshwater crayfish and is caused by the oomycete Aphanomyces astaci (Ap. astaci), believed to have been introduced to Europe around 1860. All European species of freshwater crayfish are susceptible to the disease, including the white-clawed crayfish Austropotamobius pallipes. Ap. astaci is primarily spread by North American crayfish species and can also disperse rapidly through contaminated wet gear moved between water bodies. This spread, coupled with competition from non-indigenous crayfish, has drastically reduced and fragmented native crayfish populations across Europe. Remarkably, the island of Ireland remained free from the crayfish plague pathogen for over 100 years, providing a refuge for A. pallipes. However, this changed in 1987 when a mass mortality event was linked to the pathogen, marking its introduction to the region. Fortunately, crayfish plague was not detected again in Ireland until 2015 when a molecular analysis linked a mass mortality event in the Erne catchment to Ap. astaci. Since then, the pathogen has appeared across the island. Between 2015 and 2023, Ap. astaci was detected in 18 water catchments, revealing multiple genotypes. Intriguingly, the pathogen in Ireland is present without its natural host species. The uneven distribution of various genetic lineages strongly suggests the human-mediated transport of zoospores via contaminated water equipment as a primary cause of spread. This review details the timeline of these events, Ap. astaci’s introduction into Ireland, and its rapid spread. As well, this review references the genotypes that have been determined, and discusses the issue of non-indigenous crayfish species in Ireland and management efforts.
Incorporation of Diketopyrrolopyrrole into Polythiophene for the Preparation of Organic Polymer Transistors
Authors: Ren Shiwei , Wang Zhuoer , Zhang Wenqing , Yassar Abderrahim , Chen Jinyang , Wang Sichun
Published: January 2024

Polythiophene, as a class of potential electron donor units, is widely used in organic electronics such as transistors. In this work, a novel polymeric material, PDPPTT-FT, was prepared by incorporating the electron acceptor unit into the polythiophene system. The incorporation of the DPP molecule assists in improving the solubility of the material and provides a convenient method for the preparation of field effect transistors via subsequent solution processing. The introduction of fluorine atoms forms a good intramolecular conformational lock, and theoretical calculations show that the structure displays excellent co-planarity and regularity. Grazing incidence wide-angle X-ray (GIWAXS) results indicate that the PDPPTT-FT is highly crystalline, which facilitates carrier migration within and between polymer chains. The hole mobility of this π-conjugated material is as high as 0.30 cm2 V−1 s−1 in organic transistor measurements, demonstrating the great potential of this polymer material in the field of optoelectronics.
DSC, TGA-FTIR and FTIR Assisted by Chemometric Factor Analysis and PXRD in Assessing the Incompatibility of the Antiviral Drug Arbidol Hydrochloride with Pharmaceutical Excipients
Authors: Rojek Barbara , Bartyzel Agata , Sawicki Wiesław , Plenis Alina
Published: January 2024

Arbidol hydrochloride is an antiviral product widely used in Russia and China for the treatment of, among other diseases, influenza. In recent years, it has turned out to be highly effective against COVID-19. However, there is little knowledge about its physicochemical properties and its behavior in the presence of various pharmaceutical excipients, which could be useful in the development of new preparations by increasing its solubility and bioavailability. For this reason, binary mixtures composed of arbidol hydrochloride and selected pharmaceutical excipients such as chitosan, polyvinylpyrrolione K-30 and magnesium stearate were prepared and subjected to differential scanning calorimetry (DSC), thermogravimetry combined with Fourier transform infrared spectrometry (TGA-FTIR) and Fourier transform infrared spectrometry (FTIR) analyses. In order to obtain clarity in the interpretation of the outcomes, chemometric calculations with factor analysis (FA) were used. Additionally, a powder X-ray diffraction (PXRD) and an intrinsic dissolution rate study were performed for arbidol hydrochloride itself and in the presence of excipients. As a result of the study, it was revealed that arbidol hydrochloride may undergo polymorphic transformations and be incompatible with chitosan and magnesium stearate. However, mixing arbidol hydrochloride with polyvinylpyrrolidone K-30 guarantees the obtaining of durable and safe pharmaceutical preparations.
Nanostructure Lipid Carrier of Curcumin Co-Delivered with Linalool and Geraniol Monoterpenes as Acetylcholinesterase Inhibitor of Culex pipiens
Authors: Radwan Ibrahim Taha , Ghazawy Nirvina Abdel Raouf , Alkhaibari Abeer Mousa , Gattan Hattan S. , Alruhaili Mohammed H. , Selim Abdelfattah , Salem Mostafa E. , AbdelFattah Eman Alaaeldin , Hamama Heba M.
Published: January 2024

(1) Background: A molecular hybridization docking approach was employed to develop and detect a new category of naturally activated compounds against Culex pipiens as acetylcholinesterase inhibitors via designing a one-pot multicomponent nano-delivery system. (2) Methods: A nanostructure lipid carrier (NLC), as a second generation of solid lipid nanoparticles, was used as a carrier to deliver the active components of curcumin (Cur), geraniol (G), and linalool (L) in one nanoformulation after studying their applicability in replacing the co-crystallized ligand imidacloprid. (3) Results: The prepared nanostructure showed spherical-shaped, polydisperse particles ranging in size from 50 nm to 300 nm, as found using a transmission electron microscope. Additionally, dynamic light scattering confirmed an average size of 169 nm and a highly stable dispersed solution, as indicated by the zeta potential (−38 mV). The prepared NLC-Cur-LG displayed competitive, high-malignancy insecticidal activity against fourth instar C. pipiens with an elevated rate of death of 0.649 µg/mL. The treatment, due to the prepared nanostructure, affects oxidative stress enzymes, e.g., hydrogen peroxide (4 ppm), superoxide dismutase (SOD) (0.03 OD/mg), and protein carbonyl (0.08 OD/mg), and there are observable upward and downward fluctuations when using different concentrations of NLC-Cur-LG, suggesting significant problems in its foreseeable insecticidal activity. The acetylcholinesterase activity was assessed by an enzyme inhibition assay, and strengthened inhibition occurred due to the encapsulated NLCs (IC50 = 1.95 µg/mL). An investigation of the gene expression by Western blotting, due to treatment with NLC-Cur-LG, revealed a severe reduction of nearly a quarter of what was seen in the untreated group. As a preliminary safety step, the nanoformulation’s toxicity against normal cell lines was tested, and a reassuring result was obtained of IC50 = 158.1 µg/mL for the normal lung fibroblast cell line. (4) Conclusions: the synthesized nanoformulation, NLC-Cur-LG, is a useful insecticide in field conditions.
Opioid/Dopamine Receptor Binding Studies, NMR and Molecular Dynamics Simulation of LENART01 Chimera, an Opioid-Bombesin-like Peptide
Authors: Serafin Pawel , Szeleszczuk Łukasz , Zhukov Igor , Szűcs Edina , Gombos Dávid , Stefanucci Azzurra , Mollica Adriano , Pisklak Dariusz Maciej , Kleczkowska Patrycja
Published: January 2024

The design and development of hybrid compounds as a new class of drug candidates remains an excellent opportunity to improve the pharmacological properties of drugs (including enzymatic stability, efficacy and pharmacokinetic and pharmacodynamic profiles). In addition, considering various complex diseases and/or disorders, the conjugate chemistry approach is highly acceptable and justified. Opioids have long been recognized as the most potent analgesics and serve as the basic pharmacophore for potent hybrid compounds that may be useful in pain management. However, a risk of tolerance and physical dependence exists. Since dopamine receptors have been implicated in the aforementioned adverse effects of opioids, the construction of a hybrid with dual action at opioid and dopamine receptors is of interest. Herein, we present nuclear magnetic resonance (NMR) spectroscopy and molecular dynamics simulation results for LENART01, an opioid–ranatensin hybrid peptide. Apart from molecular docking, protein–ligand interactions were also assessed in vitro using a receptor binding assay, which proved LENART01 to be bound to mu-opioid and dopamine receptors, respectively.
Enhanced Electrostatic Safety and Thermal Compatibility of Special Powders Based on Surface Modification
Authors: Pan Xuchao , Zhang Libo , Guan Jialu , Lv Jing , Xie Yifei , Yang Haifeng , Tan Linghua
Published: January 2024

Electrostatic accumulation is associated with almost all powder-conveying processes which could bring about electrostatic discharges. In most cases of industrial accidents, electrostatic discharge is proven to be the primary source of ignition and explosion. Herein, a surface modification process of polyaniline (PANI) is proposed to construct highly exothermic special powders, namely, HMX@PANI energetic composites, with low charge accumulation for improving powder electrostatic safety. Pure HMX are encapsulated within the PANI-conductive polymer layer through simple hydrogen bonding. Simulation results demonstrate that the forming process of HMX/aniline structure is a spontaneously thermodynamical process. The resultant inclusion complex exhibits excellent thermal stability, remarkable compatibility and intensive heat release. Importantly, PANI possesses superior electrostatic mobility characteristics because of the π-conjugated ligand, which can significantly reduce the accumulated charges on the surface of energetic powders. Moreover, the modified explosive has a narrower energy gap, which will improve the electron transition by reducing the energy barrier. The electrostatic accumulation test demonstrates that HMX@PANI composites possess a trace electrostatic accumulation of 34 nC/kg, which is two orders of magnitude lower than that of pure HMX (−6600 nC/kg) and might indicate a higher electrostatic safety. In conclusion, this surface modification process shows great promise for potential applications and could be extensively used in the establishment of high electrostatic safety for special powders.
Mechanism Exploration of the Effect of Polyamines on the Polishing Rate of Silicon Chemical Mechanical Polishing: A Study Combining Simulations and Experiments
Authors: Lin Ziwei , Zhu Junli , Huang Qi , Zhu Lei , Li Weimin , Yu Wenjie
Published: January 2024

Polyamines have become important chemical components used in several integrated circuit manufacturing processes, such as etching, chemical mechanical polishing (CMP), and cleaning. Recently, researchers pointed out that polyamines can be excellent enhancers in promoting the material removal rate (MRR) of Si CMP, but the interaction mechanism between the polyamines and the silicon surface has not been clarified. Here, the micro-interaction mechanisms of polyamines, including ethylenediamine (EDA), diethylenetriamine (DETA), triethylenetetramine (TETA), tetraethylenepentamine (TEPA), and pentaethylenehexamine (PEHA), with the Si(1, 0, 0) surface were investigated through molecular dynamics (MD) simulations using the ReaxFF reactive force field. Polyamines can adsorb onto the Si(1, 0, 0) surface, and the adsorption rate first accelerates and then tends to stabilize with the increase in the quantity of -CH2CH2NH-. The close connection between the adsorption properties of polyamines and the polishing rate has been confirmed by CMP experiments on silicon wafers. A comprehensive bond analysis indicates that the adsorption of polyamines can stretch surface Si–Si bonds, which facilitates subsequent material removal by abrasive mechanical wear. This work reveals the adsorption mechanism of polyamines onto the silicon substrate and the understanding of the MRR enhancement in silicon CMP, which provides guidance for the design of CMP slurry.
The Effects of a High-Carbohydrate versus a High-Fat Shake on Biomarkers of Metabolism and Glycemic Control When Used to Interrupt a 38-h Fast: A Randomized Crossover Study
Authors: Deru Landon , Gipson Elizabeth , Hales Katelynn , Bikman Benjamin , Davidson Lance , Horne Benjamin , LeCheminant James , Tucker Larry , Bailey Bruce
Published: January 2024

This study aimed to determine the impact of various fast-interrupting shakes on markers of glycemic control including glucose, β-hydroxybutyrate (BHB), insulin, glucagon, GLP-1, and GIP. Twenty-seven sedentary adults (twelve female, fifteen male) with overweight or obesity completed this study. One condition consisted of a 38-h water-only fast, and the other two conditions repeated this, but the fasts were interrupted at 24 h by either a high carbohydrate/low fat (HC/LF) shake or an isovolumetric and isocaloric low carbohydrate/high fat (LC/HF) shake. The water-only fast resulted in 135.3% more BHB compared to the HC/LF condition (p < 0.01) and 69.6% more compared to the LC/HF condition (p < 0.01). The LC/HF condition exhibited a 38.8% higher BHB level than the HC/LF condition (p < 0.01). The area under the curve for glucose was 14.2% higher in the HC/LF condition than in the water condition (p < 0.01) and 6.9% higher compared to the LC/HF condition (p < 0.01), with the LC/HF condition yielding 7.8% more glucose than the water condition (p < 0.01). At the 25-h mark, insulin and glucose-dependent insulinotropic polypeptide (GIP) were significantly elevated in the HC/LF condition compared to the LC/HF condition (p < 0.01 and p = 0.02, respectively) and compared to the water condition (p < 0.01). Furthermore, insulin, GLP-1, and GIP were increased in the LC/HF condition compared to the water condition at 25 h (p < 0.01, p = 0.015, and p < 0.01, respectively). By the 38-h time point, no differences were observed among the conditions for any of the analyzed hormones. While a LC/HF shake does not mimic a fast completely, it does preserve some of the metabolic changes including elevated BHB and glucagon, and decreased glucose and insulin compared to a HC/LF shake, implying a potential for improved metabolic health.
Protective Effect of Artocarpus heterophyllus Lam. (Jackfruit) Polysaccharides on Liver Injury Induced by Cyclophosphamide in Mice
Authors: Cheng Ming , Zheng Yifan , Wu Gang , Tan Lehe , Xu Fei , Zhang Yanjun , Chen Xiaoai , Zhu Kexue
Published: January 2024

In recent years, Artocarpus heterophyllus Lam. (jackfruit) polysaccharides (namely JFP-Ps) have attracted much attention due to their multiple biological activities. This study aimed to explore the protective effects and the underlying mechanisms of JFP-Ps on cyclophosphamide (Cp)-induced liver damage. The protective effect of JFP-Ps was evaluated using HE staining, antioxidant testing, enzyme-linked immunosorbent assay (ELISA), real-time quantitative polymerase chain reaction (RT-qPCR), Western blot and ultra-performance liquid chromatography equipped with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS) metabolomics analysis. The results showed that Cp caused pathological liver damage, activated oxidative stress and downregulated cytokine expression, while JFP-Ps treatment was found to exert antioxidant effects and play immune regulatory roles through mitogen-activated protein kinase/nuclear factor-κB (MAPK/NF-κB) related inflammation and cell apoptosis pathways to protect the Cp-induced liver injury. Metabolomic results showed that the liver-protective effects of JFP-Ps were mainly related to aminoacyl transfer ribonucleic acid (tRNA) biosynthesis, sphingolipid metabolism, purine metabolism and the citrate cycle. These results indicate that JFP-Ps have great potential application in alleviating liver injury.
Understanding the Knowledge, Attitudes, and Practices of Healthy Eating among Adolescents in Chongqing, China: An Empirical Study Utilizing Structural Equation Modeling
Authors: Jiang Ke , Zhang Laixi , Xie Changxiao , Li Zhourong , Shi Zumin , Sharma Manoj , Zhao Yong
Published: January 2024

Healthy eating is crucial for optimal growth, development, and the prevention of chronic diseases in adolescents. Our study aimed to develop a comprehensive structural equation model (SEM) to analyze the relationships between knowledge, attitudes, practices (KAP), and healthy eating among adolescents in Chongqing. An online questionnaire was administered to middle school students in 39 districts and counties of Chongqing, China from 2 December to 15 December 2021 to collect sociodemographic and KAP information. SEM models were constructed to examine the relationships between educational environment and healthy eating knowledge, attitudes, and practices. The Monte Carlo test was employed to assess the significance of the mediating effect of relevant variables. The study included 139,832 adolescents aged 14.8 ± 0.7 years, with a 14% rate of overweight and obesity. Health and nutrition knowledge averaged a score of 3.60 ± 1.50 (correct rate: 60%). Participants had positive attitudes (average score: 13.61 ± 2.29) and engaged in healthy eating practices (average score: 12.06 ± 3.08). The results of the SEM revealed a significant influence of the educational environment on adolescents’ knowledge (β = 0.235, p < 0.001) and attitude towards healthy eating (β = 0.143, p < 0.001). Knowledge exhibited positive effects on both attitude (β = 0.225, p < 0.001) and practice (β = 0.054, p < 0.001), while attitude exhibited positive effects on practice behavior (β = 0.565, p < 0.001). The indirect effect of knowledge on practices through attitude was more substantial than the direct effect (ratio 2.361). Our study highlights the mediating role of attitude between healthy eating knowledge and practices. A significant association exists between a favorable educational environment and improved knowledge and positive attitudes toward healthy eating among adolescents. In the future, nutrition and health education should prioritize exploring effective ways to translate knowledge into practices.
Intermittent Fasting: Does It Affect Sports Performance? A Systematic Review
Authors: Conde-Pipó Javier , Mora-Fernandez Agustín , Martinez-Bebia Manuel , Gimenez-Blasi Nuria , Lopez-Moro Alejandro , Latorre José Antonio , Almendros-Ruiz Antonio , Requena Bernardo , Mariscal-Arcas Miguel
Published: January 2024

Intermittent fasting is one of the most popular types of diet at the moment because it is an effective nutritional strategy in terms of weight loss. The main objective of this review is to analyze the effects that intermittent fasting has on sports performance. We analyzed physical capacities: aerobic capacity, anaerobic capacity, strength, and power, as well as their effect on body composition. For this, a bibliographic search was carried out in several databases where 25 research articles were analyzed to clarify these objectives. Inclusion criteria: dates between 2013 and present, free full texts, studies conducted in adult human athletes, English and/or Spanish languages, and if it has been considered that intermittent fasting is mainly linked to sports practice and that this obtains a result in terms of performance or physical capacities. This review was registered in PROSPERO with code ref. 407024, and an evaluation of the quality or risk of bias was performed. After this analysis, results were obtained regarding the improvement of body composition and the maintenance of muscle mass. An influence of intermittent fasting on sports performance and body composition is observed. It can be concluded that intermittent fasting provides benefits in terms of body composition without reducing physical performance, maintenance of lean mass, and improvements in maximum power. But despite this, it is necessary to carry out new studies focusing on the sports field since the samples have been very varied. Additionally, the difference in hours of intermittent fasting should be studied, especially in the case of overnight fasting.
Nursing Roles in the Quality of Information in Informed Consent Forms of a Spanish County Hospital
Authors: García-Álvarez José Manuel , García-Sánchez Alfonso
Published: January 2024

(1) Background: Because of their direct and continuous contact with the patient, nurses play a relevant role in ensuring that informed consent forms are complete and easy to read and comprehend. The objective of this study was to analyze the legibility and formal quality of informed consent forms for non-surgical procedures in a county hospital. (2) Methods: The readability of these forms was analyzed using the INFLESZ scale and the information they provided according to the formal quality criteria established for these forms. (3) Results: Readability was difficult in 78.08% of the forms analyzed. No form fulfilled all the criteria, the most non-compliant being the non-appearance of the verification of delivery of a copy to the patient (100%), the contraindications (94.59%), and the alternatives (83.78%) of the procedure. Statistically significant differences were observed between disciplines with respect to the INFLESZ readability score and the formal quality score, but no statistically significant correlation was found between the two scores. (4) Conclusions: The informed consent forms for non-surgical procedures analyzed presented mostly difficult readability and poor formal quality, making it difficult for patients to have understandable and complete information. Nursing professionals should be actively involved in their improvement to facilitate patient decision making.
Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line
Authors: de Godoy Maria Carolina Ximenes , Macedo Juliana Alves , Gambero Alessandra
Published: January 2024

Therapeutically targeting senescent cells seems to be an interesting perspective in treating chronic lung diseases, which are often associated with human aging. The combination of the drug dasatinib and the polyphenol quercetin is used in clinical trials as a senolytic, and the first results point to the relief of physical dysfunction in patients with idiopathic pulmonary fibrosis. In this work, we tested new combinations of drugs and polyphenols, looking for senolytic activity using human lung fibroblasts (MRC-5 cell line) with induced senescence. We researched drugs, such as azithromycin, rapamycin, metformin, FK-506, aspirin, and dasatinib combined with nine natural polyphenols, namely caffeic acid, chlorogenic acid, ellagic acid, ferulic acid, gallic acid, epicatechin, hesperidin, quercetin, and resveratrol. We found new effective senolytic combinations with dasatinib and ellagic acid and dasatinib and resveratrol. Both drug combinations increased apoptosis, reduced BCL-2 expression, and increased caspase activity in senescent MRC-5 cells. Ellagic acid senolytic activity was more potent than quercetin, and resveratrol counteracted inflammatory cytokine release during senolysis in vitro. In conclusion, dasatinib and ellagic acid and dasatinib and resveratrol present in vitro senolytic potential like that observed for the combination in clinical trials of dasatinib and quercetin, and maybe they could be future alternatives in the senotherapeutic field.
Rigidity with Flexibility: Porous Triptycene Networks for Enhancing Methane Storage
Authors: Guo Fei , Ma Hui , Yang Bin-Bin , Wang Zhen , Meng Xiang-Gao , Bu Jian-Hua , Zhang Chun
Published: January 2024

In the pursuit of advancing materials for methane storage, a critical consideration arises given the prominence of natural gas (NG) as a clean transportation fuel, which holds substantial potential for alleviating the strain on both energy resources and the environment in the forthcoming decade. In this context, a novel approach is undertaken, employing the rigid triptycene as a foundational building block. This strategy is coupled with the incorporation of dichloromethane and 1,3-dichloropropane, serving as rigid and flexible linkers, respectively. This combination not only enables cost-effective fabrication but also expedites the creation of two distinct triptycene-based hypercrosslinked polymers (HCPs), identified as PTN-70 and PTN-71. Surprisingly, despite PTN-71 manifesting an inferior Brunauer–Emmett–Teller (BET) surface area when compared to the rigidly linked PTN-70, it showcases remarkably enhanced methane adsorption capabilities, particularly under high-pressure conditions. At a temperature of 275 K and a pressure of 95 bars, PTN-71 demonstrates an impressive methane adsorption capacity of 329 cm3 g−1. This exceptional performance is attributed to the unique flexible network structure of PTN-71, which exhibits a pronounced swelling response when subjected to elevated pressure conditions, thus elucidating its superior methane adsorption characteristics. The development of these advanced materials not only signifies a significant stride in the realm of methane storage but also underscores the importance of tailoring the structural attributes of hypercrosslinked polymers for optimized gas adsorption performance.
The Application of Dextran Sodium Sulfate to the Efficient Separation of Ilmenite and Forsterite, as a Flotation Depressant
Authors: Fan Guixia , Zhang Huaiyao , Tian Fuqiang , Wang Hongbin , Xu Longhua , Cao Yijun , Xu Hongxiang , Zhang Fanfan , He Jianyong , Li Guosheng
Published: January 2024

A depressant is essential to the effective flotation-based separation of ilmenite and forsterite, based on their comparable physicochemical characteristics. In this work, dextran sodium sulfate (DSS) was initially introduced as a depressant, to aid in the separation of ilmenite and forsterite. Comparing the DSS to conventional natural starch, the results indicate that the forsterite exerts a greater depression over the ilmenite. The difference in recovery of ilmenite and forsterite was 75.44% at 10 mg/L of DSS dosage. The DSS was chemisorbed strongly onto the forsterite surface via Mg active sites, whereas its interaction with the ilmenite surface via physisorption was weak, based on the XPS and molecular-dynamics-simulation analyses. The results of the AFM and QCM-D investigations showed that the DSS adsorption layer on the forsterite surface was larger than those on the ilmenite surface. Consequently, DSS may function as a depressant, to effectively separate forsterite from ilmenite ore.
The Role of Education on Human Dignity: Fostering Peace and Diminishing Violence
Authors: Kleindienst Petra
Published: January 2024

The concept of human dignity postulates that every individual inherently possesses intrinsic worth. This means that upholding human dignity demands an end to war and violence. Rooted in Catholic social teachings, human life is sacred, and the dignity of the human being is the foundation of a moral vision for society. This becomes instrumental in educating students about the imperative nature of respect, empathy and compassion towards all, irrespective of sociocultural backgrounds and individual beliefs. Given the profound implications held by the concept of human dignity, through their influence on their students, Catholic educational institutions can wield substantial influence in fostering peacebuilding initiatives and mitigating conflict. This research article presents a comparative study between California and Slovenia, highlighting variations in the autonomy of Catholic high schools in terms of teaching and curriculum development and implementation. Qualitative research into private Catholic high schools in these two states shows that those with greater autonomy tend to foster a more comprehensive grasp of human dignity. These schools also demonstrate students’ enhanced ability to swiftly detect violations of human dignity, even when such breaches are not immediately evident. These observations emphasise the crucial role Catholic educational settings thereby play in the realm of peacebuilding and conflict deterrence, underscoring the need to embed a profound comprehension of human dignity in the educational framework.
The Crusades from a Historical Perspective: Communication, Culture, and Religion
Authors: Menache Sophia
Published: January 2024

The Crusades have attracted scholarly attention ever since Pope Urban II called for the recovery of the Holy Land at the Council of Clermont (27 December 1095) [...]
Typhoon-Induced Extreme Sea Surface Temperature Drops in the Western North Pacific and the Impact of Extra Cooling Due to Precipitation
Authors: Lin Jia-Yi , Ho Hua , Zheng Zhe-Wen , Tseng Yung-Cheng , Lu Da-Guang
Published: January 2024

Sea surface temperature (SST) responses have been perceived as crucial to consequential tropical cyclone (TC) intensity development. In addition to regular cooling responses, a few TCs could cause extreme SST drops (ESSTDs) (e.g., SST drops more than 6 °C) during their passage. Given the extreme temperature differences and the consequentially marked air–sea flux modulations, ESSTDs are intuitively supposed to play a serious role in modifying TC intensities. Nevertheless, the relationship between ESSTDs and consequential storm intensity changes remains unclear. In this study, satellite-observed microwave SST drops and the International Best Track Archive for Climate Stewardship TC data from 2001 to 2021 were used to elucidate the relationship between ESSTDs and the consequential TC intensity changes in the Western North Pacific typhoon season (July–October). Subsequently, the distributed characteristics of ESSTDs were systematically examined based on statistical analyses. Among them, Typhoon Kilo (2015) triggered an unexpected ESSTD behind its passage, according to existing theories. Numerical experiments based on the Regional Ocean Modeling System were carried out to explore the possible mechanisms that resulted in the ESSTD due to Kilo. The results indicate that heavy rainfall leads to additional SST cooling through the enhanced sensible heat flux leaving the surface layer in addition to the cooling from momentum-driven vertical mixing. This process enhanced the sensible heat flux leaving the sea surface since the temperature of the raindrops could be much colder than the SST in the tropical ocean, specifically under heavy rainfall and relatively less momentum entering the upper ocean during Kilo.
Transparency as a Means to Analyse the Impact of Inertial Sensors on Users during the Occupational Ergonomic Assessment: A Systematic Review
Authors: García-Luna Marco A. , Ruiz-Fernández Daniel , Tortosa-Martínez Juan , Manchado Carmen , García-Jaén Miguel , Cortell-Tormo Juan M.
Published: January 2024

The literature has yielded promising data over the past decade regarding the use of inertial sensors for the analysis of occupational ergonomics. However, despite their significant advantages (e.g., portability, lightness, low cost, etc.), their widespread implementation in the actual workplace has not yet been realized, possibly due to their discomfort or potential alteration of the worker’s behaviour. This systematic review has two main objectives: (i) to synthesize and evaluate studies that have employed inertial sensors in ergonomic analysis based on the RULA method; and (ii) to propose an evaluation system for the transparency of this technology to the user as a potential factor that could influence the behaviour and/or movements of the worker. A search was conducted on the Web of Science and Scopus databases. The studies were summarized and categorized based on the type of industry, objective, type and number of sensors used, body parts analysed, combination (or not) with other technologies, real or controlled environment, and transparency. A total of 17 studies were included in this review. The Xsens MVN system was the most widely used in this review, and the majority of studies were classified with a moderate level of transparency. It is noteworthy, however, that there is a limited and worrisome number of studies conducted in uncontrolled real environments.
The Origin of the Yellow Luminescence Band in Be-Doped Bulk GaN
Authors: Reshchikov Michael A. , Bockowski Michal
Published: January 2024

Photoluminescence (PL) from Be-doped bulk GaN crystals grown by the High Nitrogen Pressure Solution method was studied and compared with PL from GaN:Be layers on sapphire grown by molecular beam epitaxy and metalorganic chemical vapor deposition techniques. The yellow luminescence band in the latter is caused by the isolated BeGa acceptor (the YLBe band), while the broad yellow band in bulk GaN:Be crystals is a superposition of the YLBe band and another band, most likely the CN-related YL1 band. The attribution of the yellow band in bulk GaN:Be crystals to the BeGaON complex (a deep donor) is questioned.