bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcription Factors: The Fulcrum Between Cell Development and Carcinogenesis
Authors: Islam Zeyaul , Ali Ameena Mohamed , Naik Adviti , Eldaw Mohamed , Decock Julie , Kolatkar Prasanna R.
Published: June 2021

Higher eukaryotic development is a complex and tightly regulated process, whereby transcription factors (TFs) play a key role in controlling the gene regulatory networks. Dysregulation of these regulatory networks has also been associated with carcinogenesis. Transcription factors are key enablers of cancer stemness, which support the maintenance and function of cancer stem cells that are believed to act as seeds for cancer initiation, progression and metastasis, and treatment resistance. One key area of research is to understand how these factors interact and collaborate to define cellular fate during embryogenesis as well as during tumor development. This review focuses on understanding the role of TFs in cell development and cancer. The molecular mechanisms of cell fate decision are of key importance in efforts towards developing better protocols for directed differentiation of cells in research and medicine. We also discuss the dysregulation of TFs and their role in cancer progression and metastasis, exploring TF networks as direct or indirect targets for therapeutic intervention, as well as specific TFs’ potential as biomarkers for predicting and monitoring treatment responses.
Angiogenesis Inhibitors for Head and Neck Squamous Cell Carcinoma Treatment: Is There Still Hope?
Authors: Hyytiäinen Aini , Wahbi Wafa , Väyrynen Otto , Saarilahti Kauko , Karihtala Peeter , Salo Tuula , Al-Samadi Ahmed
Published: June 2021

Background

Head and neck squamous cell carcinoma (HNSCC) carries poor survival outcomes despite recent progress in cancer treatment in general. Angiogenesis is crucial for tumour survival and progression. Therefore, several agents targeting the pathways that mediate angiogenesis have been developed. We conducted a systematic review to summarise the current clinical trial data examining angiogenesis inhibitors in HNSCC.

Methods

We carried out a literature search on three angiogenesis inhibitor categories—bevacizumab, tyrosine kinase inhibitors and endostatin—from Ovid MEDLINE, Cochrane Library, Scopus and ClinicalTrials.gov database.

Results

Here, we analysed 38 clinical trials, total of 1670 patients, investigating 12 angiogenesis inhibitors. All trials were in phase I or II, except one study in phase III on bevacizumab. Angiogenesis inhibitors were used as mono- and combination therapies together with radio-, chemo-, targeted- or immunotherapy. Among 12 angiogenesis inhibitors, bevacizumab was the most studied drug, included in 13 trials. Although bevacizumab appeared effective in various combinations, it associated with high toxicity levels. Endostatin and lenvatinib were well-tolerated and their anticancer effects appeared promising.

Conclusions

Most studies did not show benefit of angiogenesis inhibitors in HNSCC treatment. Additionally, angiogenesis inhibitors were associated with considerable toxicity. However, some results appear encouraging, suggesting that further investigations of angiogenesis inhibitors, particularly in combination therapies, for HNSCC patients are warranted.

Systematic Review Registration

PROSPERO (https://www.crd.york.ac.uk/prospero/), identifier CRD42020157144.
The Challenge of Melanocytic Lesions in Pediatric Patients: Clinical-Pathological Findings and the Diagnostic Value of PRAME
Authors: Umano Giuseppina Rosaria , Errico Maria Elena , D’Onofrio Vittoria , Delehaye Giulia , Trotta Letizia , Spinelli Claudio , Strambi Silvia , Franco Renato , D’Abbronzo Giuseppe , Ronchi Andrea , Papparella Alfonso
Published: June 2021

Pediatric melanoma is a rare disease especially in children aged younger than 10 years old. Recent estimates report a rise of disease incidence in both adults and children. Diagnostic work-up is challenging in pediatric melanoma, as it displays a wide range of clinical presentations. Immunohistochemical biomarkers have been reported as predictors of malignancy in melanoma, however data specific to pediatric melanoma are poor. Our study aims to contribute to provide evidence of pediatric melanoma clinical features and differential diagnosis in this patient population. We describe our experience with a retrospective case series of pigmented skin lesions including malignant melanoma, atypical spitzoid tumor, and benign nevi in children and adolescents aged less than 16 years. We described the clinical and demographic characteristics of the cohort and evaluated the immunohistochemical expression of the PReferentially expressed Antigen in MElanoma (PRAME) for differential diagnosis of melanoma in children. The series displayed a similar distribution of melanoma between males and females, and the most common site of melanoma onset were the upper and lower limbs. In our cohort, PRAME was negative in most cases. Focal and slight positivity (from 1 to 5% of the neoplastic cells) was observed in four cases (two Spitz nevi and two atypical Spitz tumors). A moderate positivity in 25% of the neoplastic cells was observed in one case of atypical Spitz tumor. Immunohistochemical expression of PRAME might be useful in the differential diagnosis of malignant melanoma.
Loganin Inhibits Angiotensin II–Induced Cardiac Hypertrophy Through the JAK2/STAT3 and NF-κB Signaling Pathways
Authors: Xu Jia-jia , Li Run-jing , Zhang Zheng-hao , Yang Cui , Liu Shi-xiao , Li Yan-ling , Chen Min-wei , Wang Wei-wei , Zhang Gong-ye , Song Gang , Huang Zheng-rong
Published: June 2021

Loganin is an iridoid glycoside extracted from Cornus officinalis, which is a traditional oriental medicine, and many biological properties of loganin have been reported. Nevertheless, it is not clear whether loganin has therapeutic effect on cardiovascular diseases. Hence, the aim of the present study was to investigate the effect of loganin on Ang II–induced cardiac hypertrophy. In the present study, we reported for the first time that loganin inhibits Ang II–provoked cardiac hypertrophy and cardiac damages in H9C2 cells and in mice. Furthermore, loganin can achieve cardioprotective effects through attenuating cardiac fibrosis, decreasing pro-inflammatory cytokine secretion, and suppressing the phosphorylation of critical proteins such as JAK2, STAT3, p65, and IκBα. Besides, the outstanding findings of the present study were to prove that loganin has no significant toxicity or side effects on normal cells and organs. Based on these results, we conclude that loganin mitigates Ang II–induced cardiac hypertrophy at least partially through inhibiting the JAK2/STAT3 and NF-κB signaling pathways. Accordingly, the natural product, loganin, might be a novel effective agent for the treatment of cardiac hypertrophy and heart failure.
A Repurposed Drug Screen Identifies Compounds That Inhibit the Binding of the COVID-19 Spike Protein to ACE2
Authors: Tsegay Kaleb B. , Adeyemi Christiana M. , Gniffke Edward P. , Sather D. Noah , Walker John K. , Smith Stephen E. P.
Published: June 2021

Repurposed drugs that block the interaction between the SARS-CoV-2 spike protein and its receptor ACE2 could offer a rapid route to novel COVID-19 treatments or prophylactics. Here, we screened 2,701 compounds from a commercial library of drugs approved by international regulatory agencies for their ability to inhibit the binding of recombinant, trimeric SARS-CoV-2 spike protein to recombinant human ACE2. We identified 56 compounds that inhibited binding in a concentration-dependent manner, measured the IC50of binding inhibition, and computationally modeled the docking of the best inhibitors to the Spike-ACE2 binding interface. The best candidates were Thiostrepton, Oxytocin, Nilotinib, and Hydroxycamptothecin with IC50’s in the 4–9 μM range. These results highlight an effective screening approach to identify compounds capable of disrupting the Spike-ACE2 interaction, as well as identify several potential inhibitors of the Spike-ACE2 interaction.
The Impact of Glucagon-Like Peptide 1 Receptor Agonists on Bone Metabolism and Its Possible Mechanisms in Osteoporosis Treatment
Authors: Xie Baocheng , Chen Shichun , Xu Yongxiang , Han Weichao , Hu Runkai , Chen Minyi , Zhang Yusheng , Ding Shaobo
Published: June 2021

Diabetes mellitus and osteoporosis are closely related and have complex influencing factors. The impact of anti-diabetic drugs on bone metabolism has received more and more attention. Type 2 diabetes mellitus (T2DM) would lead to bone fragility, high risk of fracture, poor bone repair and other bone-related diseases. Furthermore, hypoglycemic drugs used to treat T2DM may have notable detrimental effects on bones. Thus, the clinically therapeutic strategy for T2DM should not only effectively control the patient’s glucose levels, but also minimize the complications of bone metabolism diseases. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel and promising drug for the treatment of T2DM. Some studies have found that GLP-1RAs may play an anti-osteoporotic effect by controlling blood sugar levels, promoting bone formation and inhibiting bone resorption. However, in clinical practice, the specific effects of GLP-1RA on fracture risk and osteoporosis have not been clearly defined and evidenced. This review summarizes the current research findings by which GLP-1RAs treatment of diabetic osteoporosis, postmenopausal osteoporosis and glucocorticoid-induced osteoporosis and describes possible mechanisms, such as GLP-1R/MAPK signaling pathway, GLP-1R/PI3K/AKT signaling pathway and Wnt/β-catenin pathway, that are associated with GLP-1RAs and osteoporosis. The specific role and related mechanisms of GLP-1RAs in the bone metabolism of patients with different types of osteoporosis need to be further explored and clarified.
Electronic Currents and Magnetic Fields in H2+ Induced by Coherent Resonant Bichromatic Circularly Polarized Laser Pulses: Effects of Orientation, Phase, and Helicity
Authors: Bandrauk André D. , Chelkowski Szczepan , Yuan Kai-Jun
Published: June 2021

We theoretically study pulse phase and helicity effects on ultrafast magnetic field generation in intense bichromatic circularly polarized laser fields. Simulations are performed on the aligned molecular ion H2+ from numerical solutions of corresponding time-dependent Schrödinger equations. We demonstrate how electron coherent resonant excitation influences the phase and helicity of the optically induced magnetic field generation. The dependence of the generated magnetic field on the pulse phase arises from the interference effect between multiple excitation and ionization pathways, and is shown to be sensitive to molecular alignment and laser polarization. Molecular resonant excitation induces coherent ring electron currents, giving enhancement or suppression of the phase dependence. Pulse helicity effects control laser-induced electron dynamics in bichromatic circular polarization excitation. These phenomena are demonstrated by a molecular attosecond photoionization model and coherent electron current theory. The results offer a guiding principle for generating ultrafast magnetic fields and for studying coherent electron dynamics in complex molecular systems.
Gene Replacement in Arabidopsis Reveals Manganese Transport as an Ancient Feature of Human, Plant and Cyanobacterial UPF0016 Proteins
Authors: Hoecker Natalie , Hennecke Yvonne , Schrott Simon , Marino Giada , Schmidt Sidsel Birkelund , Leister Dario , Schneider Anja
Published: June 2021

The protein family 0016 (UPF0016) is conserved through evolution, and the few members characterized share a function in Mn2+ transport. So far, little is known about the history of these proteins in Eukaryotes. In Arabidopsis thaliana five such proteins, comprising four different subcellular localizations including chloroplasts, have been described, whereas non-photosynthetic Eukaryotes have only one. We used a phylogenetic approach to classify the eukaryotic proteins into two subgroups and performed gene-replacement studies to investigate UPF0016 genes of various origins. Replaceability can be scored readily in the Arabidopsis UPF0016 transporter mutant pam71, which exhibits a functional deficiency in photosystem II. The N-terminal region of the Arabidopsis PAM71 was used to direct selected proteins to chloroplast membranes. Transgenic pam71 lines overexpressing the closest plant homolog (CMT1), human TMEM165 or cyanobacterial MNX successfully restored photosystem II efficiency, manganese binding to photosystem II complexes and consequently plant growth rate and biomass production. Thus AtCMT1, HsTMEM165, and SynMNX can operate in the thylakoid membrane and substitute for PAM71 in a non-native environment, indicating that the manganese transport function of UPF0016 proteins is an ancient feature of the family. We propose that the two chloroplast-localized UPF0016 proteins, CMT1 and PAM71, in plants originated from the cyanobacterial endosymbiont that gave rise to the organelle.
Emotional Nuance Enhances Verbatim Retention of Written Materials
Authors: Kim Yoonji , Sidtis Diana Van Lancker , Sidtis John J.
Published: June 2021

Recent studies have demonstrated that details of verbal material are retained in memory. Further, converging evidence points to a memory-enhancing effect of emotion such that memory for emotional events is stronger than memory for neutral events. Building upon this work, it appears likely that verbatim sentence forms will be remembered better when tinged with emotional nuance. Most previous studies have focused on single words. The current study examines the role of emotional nuance in the verbatim retention of longer sentences in written material. In this study, participants silently read transcriptions of spontaneous narratives, half of which had been delivered within a context of emotional expression and the other half with neutral expression. Transcripts were taken from selected narratives that received the highest, most extreme ratings, neutral or emotional. Participants identified written excerpts in a yes/no recognition test. Results revealed that participants’ verbatim memory was significantly greater for excerpts from emotionally nuanced narratives than from neutral narratives. It is concluded that the narratives, pre-rated as emotional or neutral, drove this effect of emotion on verbatim retention. These findings expand a growing body of evidence for a role of emotion in memory, and lend support to episodic theories of language and the constructionist account.
The Double Framing Effect of Emotive Metaphors in Argumentation
Authors: Ervas Francesca , Rossi Maria Grazia , Ojha Amitash , Indurkhya Bipin
Published: June 2021

In argumentation, metaphors are often considered as ambiguous or deceptive uses of language leading to fallacies of reasoning. However, they can also provide useful insights into creative argumentation, leading to genuinely new knowledge. Metaphors entail a framing effect that implicitly provides a specific perspective to interpret the world, guiding reasoning and evaluation of arguments. In the same vein, emotions could be in sharp contrast with proper reasoning, but they can also be cognitive processes of affective framing, influencing our reasoning and behavior in different meaningful ways. Thus, a double (metaphorical and affective) framing effect might influence argumentation in the case of emotive metaphors, such as “Poverty is a disease” or “Your boss is a dictator,” where specific “emotive words” (disease, dictator) are used as vehicles. We present and discuss the results of two experimental studies designed to explore the role of emotive metaphors in argumentation. The studies investigated whether and to what extent the detection of a fallacious argument is influenced by the presence of a conventional vs. novel emotive metaphor. Participants evaluated a series of verbal arguments containing either “non-emotive” or “emotive” (positive or negative) metaphors as middle terms that “bridge” the premises of the argument. The results show that theaffective coherenceof the metaphor's vehicle and topic plays a crucial role in participants' reasoning style, leading to global heuristic vs. local analytical interpretive processes in the interplay of the metaphorical and the affective framing effects.
Interparental Conflict and Korean Children’s Inhibitory Control: Testing Emotional Insecurity as a Mediator
Authors: Lee Young-Eun , Seo SoJung
Published: June 2021

This study examined the association between interparental conflict and inhibitory control of Korean children, and it investigated whether this relationship is mediated by the single latent variable of emotional insecurity or by three dimensions of emotional insecurity (i.e., involvement, emotional reactivity, and avoidance). A total of 166 mother–father dyads with Korean children aged 3–5 years participated in a short-term longitudinal survey at two-time points. Both parents completed measures of interparental conflict and emotional insecurity, and, 6 months later, they completed a measure of the inhibitory control of children. The structural equation modeling results suggested that interparental conflict was related to poor inhibitory control in Korean children. Emotional insecurity did not mediate the association between interparental conflict and inhibitory control. Of the three emotional insecurity dimensions, the involvement partially mediated the relationship. Interestingly, although interparental conflict predicted poor inhibitory control, the involvement of children in the conflict, which was associated with a greater interparental conflict, predicted a subsequent increase in inhibitory control 6 months later. These findings were interpreted in terms of sensory processing patterns, the reformulation of emotional security theory, and the influence of Confucianism on Korean culture.
Understanding Perceived Age-Based Judgement as a Precursor to Age-Based Stereotype Threat in Everyday Settings
Authors: Lamont Ruth A. , Swift Hannah J. , Drury Lisbeth
Published: June 2021

Test conditions eliciting negative stereotypes of aging among older adults can prompt age-based stereotype threat (ABST), which results in worse performance on cognitive and memory tests. Much of this research explores ABST as a phenomenon that impacts the performance of older adults. Little is known about the experience of ABST beyond performance settings and how it manifests in everyday contexts across different age groups. Gaps also remain in understanding the wider impacts of ABST, such as effects on task motivation and engagement. The current research addresses this by exploring the contexts in which age-based judgement, a theorized precursor to ABST, occurs across a wide age range of participants. The two studies in this paper present mixed-methods survey data for a total of 282 respondents aged 18–84 years. Study 1 presents a thematic analysis of open-ended responses to identify the stereotypes and settings that underpin perceived age-based judgement. The settings and stereotypes identified are discussed in relation to which contexts lend themselves to adverse ABST effects. Study 2 then asked respondents to rate the extent to which they experience threat-based concern within 12 contexts identified from Study 1. Results indicate differences in threat-based concerns between young, middle-aged and older adults for physical activity, driving, using public transport, using technology, in leadership and relating to the COVID-19 pandemic. The studies provide a foundation for future research to investigate (1) the motivational and behavioural consequences of threat-based concerns for younger adults’ driving and leadership, and in the context of the pandemic; (2) cues to ‘old’ age stereotypes and threat-based concerns among late middle-aged adults within the workplace; (3) the role of broad stereotypes of ‘incompetence’ and being ‘past-it’ on middle-aged and older adults’ engagement with technology and physical activity and (4) potential ABST effects resulting from stereotypes of older people as a burden and a problem in the context of a national crisis. Overall, this research extends our understanding of ABST by identifying further contexts and age groups that could be impacted by a wider range of ABST effects.
In Leaders We Trust, or Should We? Supervisors’ Dark Triad Personality Traits and Ratings of Team Performance and Innovation
Authors: Fodor Oana C. , Curşeu Petru L. , Meslec Nicoleta
Published: June 2021

Our study tests in a sample of 87 organizational groups (297 employees and 87 supervisors) the mediating role of leader-member exchange (LMX) and collective narcissism in the relationship between supervisors’ dark triad (SDT) personality traits and ratings of team outcomes made by supervisors and team members. We show that LMX mediates the association between SDT and team performance and innovation as rated by team members, while collective narcissism mediates the association between SDT and supervisory ratings of team innovation and team performance. Moreover, collective narcissism also mediates the association between SDT and team innovation as rated by team members. Results show that team-level performance appraisal is influenced by supervisory attributes and that the quality of relational exchanges and collective narcissism are plausible mechanisms explaining this association. The use of supervisory ratings of team outcomes in empirical research should also account for the supervisory attributes.
Igbo Speech Surrogacy: Preliminary Findings Based on the Oja Flute
Authors: Carter-Ényì Aaron , Amadi Nnaemeka C. , Carter-Ényì Quintina , Chukwudozie Charles , Nwankwo Jude , Omodoro Ebruphiyor
Published: June 2021

This research report presents analyses of recordings from the Ìgbò culture of southeastern Nigeria of anọ̀jàflute player, a female speaker, and a male speaker. After a prepared performance, the participants completed two tasks: (1) mapping speech to flute playing and (2) identifying phrases played on the flute. Contour analysis is applied to annotated recordings to study the mapping of speech tone and rhythm from voice to instrument in parallel utterances by the three participants (male, female, and flute). Response time between the flute playing and spoken phrase identification indicates each prompt’s relative clarity. Using a limited but not predetermined inventory of related praise epithets, participants successfully converted speech to music and music to speech. In the conversion of speech to music, we found that declination was not part of the mapping, indicating it is a phonetic artifact of speech and does not carry a functional load. In identifying surrogate phrases played on the flute (music to speech), we found that dialectical variation caused some misidentification because idioms known in one area of the Igbo dialect cluster are not necessarily known throughout the region. However,òòjàspeech surrogacy is found throughout the region. Possibilities and predictions for further research are presented.
The Differential Impact of Acute Exercise and Mindfulness Meditation on Executive Functioning and Psycho-Emotional Well-Being in Children and Youth With ADHD
Authors: Bigelow Hannah , Gottlieb Marcus D. , Ogrodnik Michelle , Graham Jeffrey D. , Fenesi Barbara
Published: June 2021

This study investigated how acute exercise and mindfulness meditation impacts executive functioning and psycho-emotional well-being in 16 children and youth with ADHD aged 10–14 (male = 11; White = 80%). Participants completed three interventions: 10 min of exercise, 10 min of mindfulness meditation, and 10 min of reading (control). Before and after each intervention, executive functioning (inhibitory control, working memory, task-switching) and psycho-emotional well-being (mood, self-efficacy) were assessed. Mindfulness meditation increased performance on all executive functioning tasks whereas the other interventions did not (d = 0.55–0.86). Exercise enhanced positive mood and self-efficacy whereas the other interventions did not (d = 0.22–0.35). This work provides preliminary evidence for how acute exercise and mindfulness meditation can support differential aspects of executive and psycho-emotional functioning among children and youth with ADHD.
Internet-Based Cognitive Behavioral Therapy for Psychological Distress Associated With the COVID-19 Pandemic: A Pilot Randomized Controlled Trial
Authors: Aminoff Victoria , Sellén Malin , Sörliden Elise , Ludvigsson Mikael , Berg Matilda , Andersson Gerhard
Published: June 2021

Background: The COVID-19 pandemic has been associated with various negative psychological consequences. This is a challenge for the society as regular psychological services cannot be offered to the same extent as before the pandemic. In addition to the requirement of social distancing, there is a need to adjust psychological treatment components like exposure to avoid increasing the spread of the infection. Internet-delivered cognitive behavior therapy (ICBT) has an established evidence base for a range of psychiatric problems and has been suggested as one possible approach to deal with the situation. This study aimed to conduct a randomized controlled pilot trial during the summer of 2020 with a broad focus on psychological distress and a treatment approach that tailors the intervention based on symptom profile and preferences.

Methods: Following the advertisement and interview, we included 52 participants with elevated levels of psychological distress. They were randomly allocated to either a 7-week-long individually tailored ICBT (n = 26) or a wait-list control condition (n = 26). Measures of depression and quality of life were used as primary outcomes. We also included secondary outcome measures of anxiety, insomnia, trauma, stress, anger, and alcohol use. For screening, we used the CoRonavIruS Health Impact Survey (CRISIS).

Results: Overall moderate to large between-group effects were found at post-treatment in favor of the treatment on measures of both depression [Beck Depression Inventory (BDI); Cohens d = 0.63; Patient Health Questionnaire (PHQ-9): d = 0.62] and anxiety [Generalized Anxiety Disorder-7-item scale (GAD-7); d = 0.82]. This was also observed for stress symptoms [Perceived Stress Scale (PSS-14); d = 1.04]. No effects were seen on measures of quality of life, insomnia, symptoms of post-traumatic stress, and anger. There was an effect on alcohol use [Alcohol Use Disorder Identification Test (AUDIT); d = 0.54], which was not of clinical relevance.

Conclusion: Individually tailored ICBT shows initial promise as a way to reduce psychological problems in association with the COVID-19 pandemic. A possible limitation was that the trial was conducted when the effects of the pandemic were decreasing and when fewer people were affected by the restrictions (e.g., the summer of 2020).
Contagious Health Risk and Precautionary Social Distancing
Authors: Giese Helge , Gamp Martina , Stok F. Marijn , Gaissmaier Wolfgang , Schupp Harald T. , Renner Britta
Published: June 2021

Background

Since humans are social animals, social relations are incredibly important. However, in cases of contagious diseases such as the flu, social contacts also pose a health risk. According to prominent health behavior change theories, perceiving a risk for one’s health motivates precautionary behaviors. The “behavioral immune system” approach suggests that social distancing might be triggered as a precautionary, evolutionarily learned behavior to prevent transmitting contagious diseases through social contact. This study examines the link between personal risk perception for an infectious disease and precautionary behavior for disease-prevention in the context of social relationships.

Methods

At 2-week intervals during the first semester, 100 Psychology freshmen indicated their flu risk perception, whether they had been ill during the previous week, and their friendships within their freshmen network for eight time points.

Results

Social network analysis revealed that participants who reported a high flu risk perception listed fewer friends (B = −0.10, OR = 0.91, p = 0.026), and were more likely to be ill at the next measuring point (B = 0.26, OR = 1.30, p = 0.005). Incoming friendship nominations increased the likelihood of illness (B = 0.14, OR = 1.15, p = 0.008), while the reduced number of friendship nominations only marginally decreased this likelihood (B = −0.07, OR = 0.93, p = 0.052).

Conclusion

In accordance with the concept of a “behavioral immune system,” participants with high flu risk perception displayed a social precautionary distancing even when in an environment, in which the behavior was ineffective to prevent an illness.
What Do Survivors of Child Sexual Abuse Believe Will Facilitate Early Disclosure of Sexual Abuse?
Authors: Solberg Ellen Tvedt , Halvorsen Jorunn E. , Stige Signe Hjelen
Published: June 2021

The purpose of this study was to explore what adult survivors of child sexual abuse (CSA) believe will facilitate early disclosure of sexual abuse. We conducted semi-structured interviews with 12 adult survivors of CSA aged 18–57 years, and analyzed the transcripts using reflexive thematic analysis. Our analysis resulted in three main themes: Adults making it possible to tell; Adults daring to consider the unthinkable; and Conveying knowledge of CSA that facilitates understanding. The findings highlighted the importance of adults facilitating disclosure and making it possible for survivors to tell about their experiences, but also the responsibility adults have to dare to consider the possibility of CSA when children struggle. Another important finding was the significance of enhancing the general population's understanding of the complexity of CSA, including why disclosure is difficult, so adults are given the tools needed to understand and know what to do when they suspect CSA. The findings also have important implications for the planning and implementation of interventions to facilitate early disclosure of CSA.
Psychotropic Polypharmacy in the US Pediatric Population: A Methodologic Critique and Commentary
Authors: Zito Julie M. , Zhu Yue , Safer Daniel J.
Published: June 2021

Background: Psychotropic concomitant medication use for the treatment of youth with emotional and behavioral disorders has grown significantly in the U.S. over the past 25 years. The use of pharmacy claims to analyze these trends requires the following: age of the selected population, overlapping days of use, and precision of the outcome itself. This review will also address the gaps in reporting of pediatric psychotropic polypharmacy.

Methods: An electronic literature search was undertaken for the period 2000 through 2020 using keywords such as “pediatric,” “concomitant,” “polypharmacy,” “multiple medications,” and “concurrent psychotropic”; Relevant references in textbooks were also used. Only English language and U.S. studies were included, resulting in 35 inter-class studies.

Results: Studies were organized into seven groups according to data sources and clinical topics: (1) population surveys; (2a) multi-state publicly insured populations; (2b) single/two state studies; (3) privately insured populations; (4) diagnosed populations; (5) foster care populations; (6) special settings. Across 20 years it is apparent that pediatric psychotropic polypharmacy affects substantially more children and adolescents today than had been the case. As many as 300,000 youth now receive 3 or more classes concomitantly. The duration of concomitant use is relatively long, e.g., 69–89% of annual medicated days. Finally, more adverse event reports were associated with 3-class compared with 2-class drug regimens.

Discussion: Factors that contribute to the growth of pediatric psychotropic polypharmacy include: (1) predominance of the biological model in psychiatric practice; (2) invalid assumptions on efficacy of combinations, (3) limited professional awareness of metabolic and neurological adverse drug events, and (4) infrequent use of appropriate deprescribing.

Conclusion: A review of publications documenting U.S. pediatric psychotropic polypharmacy written over the last 20 years supports the need to standardize the methodologies used. The design of population-based studies should maximize information on the number of youth receiving regimens of 3-, 4-, and 5 or more concomitant classes and the duration of such use. Next, far more post-marketing research is needed to address the effectiveness, safety and tolerability of complex drug regimens prescribed for youngsters.
Differential Effects of Psychological Interventions in Online and Face-to-Face Settings on DSM-5 and ICD-11 Maladaptive Trait Domains: An Exploratory Pilot Study
Authors: Kerber André , Schaeuffele Carmen , Krieger Tobias , Urech Antoine , Riper Heleen , Berger Thomas , Boettcher Johanna , Knaevelsrud Christine
Published: June 2021

While mental health treatments have proven to be effective for a range of mental health problems, there is comparably little research on its effects on personality disorders or difficulty (PD). New dimensional conceptualizations of PD such as the ICD-11 PD model enable the cost- and time-effective dimensional assessment of severity and style of PD. Furthermore, they constitute a promising tool to investigate PD, not only as a treatment endpoint but also as a predictive or influencing factor for mental health treatments. In this study, we investigated the effects in two different mental health treatment settings [online (N = 38); face-to-face and blended [FTF/blended] (N = 35)] on the reduction of maladaptive personality traits as well as the interaction between maladaptive personality patterns and the response on primary endpoints (i.e., mental distress). Results indicate that both treatment settings have comparable within-group effects on the reduction of distress symptoms, while the treatment in the FTF/blended setting seems to have a stronger impact on the reduction of maladaptive traits. Further, reduction of maladaptive trait expressions was a reliable predictor of treatment response in the FTF/blended setting while explaining less variance in the online setting. Beyond the promising findings on the utility of maladaptive trait change as an outcome measure, we discuss possible applications as an information source for treatment decisions.
Index Modulation–Aided Mixed Massive Random Access
Authors: Liang Zijie , Zheng Jianping , Ni Jie
Published: June 2021

In this study, a mixed massive random access scheme is considered where part of users transmit both common information and user-specific information, while others transmit only common information. In this scheme, common information is transmitted by index modulation (IM)–aided unsourced random access (URA), while user-specific information is by IM-aided sourced random access (SRA). Practically, IM-aided URA partitions channel blocks of one transmission frame into multiple groups and then employs the IM principle to activate only part of the channel blocks in each group. IM-aided SRA allocates multiple pilot sequences to each user and activates only one pilot sequence whose index carries the data information. At the receiver, the covariance-based maximum likelihood detection (CB-MLD) is employed to recover the active compressed sensing (CS) code words of URA and information of SRA jointly. To stitch the common information at different blocks of URA, a modified tree decoder is proposed to take the IM constraint into account. Furthermore, to relax the strict threshold requirement and improve the performance, an iterative CS detector and tree decoder are employed to decode the common information, where successive signal reconstruction and interference cancellation are utilized. Finally, computer simulations are given to demonstrate the performance of the proposed scheme.
Safety Assessment Review of a Dressing Assistance Robot
Authors: Delgado Bellamy Daniel , Chance Gregory , Caleb-Solly Praminda , Dogramadzi Sanja
Published: June 2021

Hazard analysis methods such as HAZOP and STPA have proven to be effective methods for assurance of system safety for years. However, the dimensionality and human factors uncertainty of many assistive robotic applications challenges the capability of these methods to provide comprehensive coverage of safety issues from interdisciplinary perspectives in a timely and cost-effective manner. Physically assistive tasks in which a range of dynamic contexts require continuous human–robot physical interaction such as e.g., robot-assisted dressing or sit-to-stand pose a new paradigm for safe design and safety analysis methodology. For these types of tasks, considerations have to be made for a range of dynamic contexts where the robot-assistance requires close and continuous physical contact with users. Current regulations mainly cover industrial collaborative robotics regarding physical human–robot interaction (pHRI) but largely neglects direct and continuous physical human contact. In this paper, we explore limitations of commonly used safety analysis techniques when applied to robot-assisted dressing scenarios. We provide a detailed analysis of the system requirements from the user perspective and consider user-bounded hazards that can compromise safety of this complex pHRI.
COVID-19 Pandemic: Rethinking Strategies for Resilient Urban Design, Perceptions, and Planning
Authors: Afrin Sadia , Chowdhury Farhat Jahan , Rahman Md. Mostafizur
Published: June 2021

From the beginning of the COVID-19 crisis, the scientific community has been continuously trying to assess the virus, its socio-environmental impacts, regulatory/adaptation policies, and plans. The emergency is to develop pandemic-resilient city planning and management in order to tackle the infectious diseases during COVID-19. Such development includes the reframing of unsustainable urban patterns, hazards, and social inequalities to be prepared for the emerging cases. In this study, we focus on the assessment of disaster risk management (DRM), which will help to develop pandemic-resilient urban strategies (response, mitigation, and preparedness phase) through analyzing previously published literature. Short- and long-term recommendations for pandemic resilience urban planning and design have also been provided. In the response phase, implementation of the smart and resilient city design and policies has been highlighted to identify disease transmission. In the mitigation phase, new technological approaches can be adopted for better management of present and future pandemics. The physical (urban access, infrastructure, environmental factors, and land use patterns) and non-physical (socio-cultural, governance, and economic factors) aspects of resilient urban strategies have been focused, which may help to develop understanding of health- and disaster-related risks in pandemic. In the preparedness phase, proactive measures such as capacity building of people toward any outbreak and different simulation processes (models of transmission pattern) can be adopted for future pandemics. We also discuss about the enhancement of urban resiliency in housing, public spaces, and cities that may bring the effective outcome of DRM framework to combat pandemic. The study focuses on the major lessons that can be adopted for post-pandemic urban resilient planning related to disaster management and climate change adaptation, preventing extensive challenges of sustainability apart. In the following months and years, it will be difficult to assess various changes to develop urban planning and design in the post-COVID-19 world. However, this study expresses the possibility of creating good opportunities for policymakers and city planners to undertake significant transformative and advanced actions during the three different phases of DRM. This study presents a novel approach to delineate the scope of DRM framework in achieving more resilient cities (RC) to tackle future pandemics. This study will also crucially help the planners and decision-makers in better assessing and addressing the strategic and resilient urban design and planning approach in future.
Eye See What You See: Exploring How Bi-Directional Augmented Reality Gaze Visualisation Influences Co-Located Symmetric Collaboration
Authors: Jing Allison , May Kieran , Lee Gun , Billinghurst Mark
Published: June 2021

Gaze is one of the predominant communication cues and can provide valuable implicit information such as intention or focus when performing collaborative tasks. However, little research has been done on how virtual gaze cues combining spatial and temporal characteristics impact real-life physical tasks during face to face collaboration. In this study, we explore the effect of showing joint gaze interaction in an Augmented Reality (AR) interface by evaluating three bi-directional collaborative (BDC) gaze visualisations with three levels of gaze behaviours. Using three independent tasks, we found that all bi-directional collaborative BDC visualisations are rated significantly better at representing joint attention and user intention compared to a non-collaborative (NC) condition, and hence are considered more engaging. The Laser Eye condition, spatially embodied with gaze direction, is perceived significantly more effective as it encourages mutual gaze awareness with a relatively low mental effort in a less constrained workspace. In addition, by offering additional virtual representation that compensates for verbal descriptions and hand pointing, BDC gaze visualisations can encourage more conscious use of gaze cues coupled with deictic references during co-located symmetric collaboration. We provide a summary of the lessons learned, limitations of the study, and directions for future research.
What Happens to the Lungs When They Get Hurt?
Authors: Boni Alexandra Jacqueline , Roque Willy , Romero Freddy
Published: June 2021

Lung fibrosis is a lung disease that primarily affects older adults and makes it hard to breathe. The lungs get scarred and thick from inflammation, so exchange of oxygen and carbon dioxide is impaired. In this article, you will first learn how the lungs allow us to breathe and why we must breathe in the first place. You will also learn what causes lung fibrosis, its symptoms, how doctors diagnose it, and the ways to treat it. You will learn that there is no cure, but that means that maybe 1 day you can discover the cure!
Making a Web-Portal With Aquaculture Sustainability Indicators for the General Public
Authors: Mikkelsen Eirik , Myhre Magnus Stoud , Robertsen Roy , Winther Ulf
Published: June 2021

The sustainability of aquaculture is a complex issue that can be hard to assess and communicate. Communicating it to the general public is in many ways an even bigger challenge than communicating to experts on sustainability or aquaculture. The general public's perception of the status and challenges for sustainability is important for the development of the aquaculture industry and for society at large, through its roles both as consumers and electorate, and generally in providing or denying a “social license to operate” for the industry. This paper presents the process and challenges involved in choosing and quality assuring sustainability indicators for Norwegian aquaculture, covering environmental, economic, and social dimensions. It involved a team of researchers, a quality assurance group, IT developers and designers, a literature review, a national survey, and user-testing, all to establish criteria for selecting data and indicators and how to present them, and to do the actual production. The endpoint is a web-portal with indicators currently covering 22 themes, aimed at anyone interested in the sustainability of Norwegian fish farming. The portal does not conclude if or to what degree Norwegian fish farming is sustainable, as that would require making valuation and trade-offs among different sustainability objectives. Many indicators are automatically updated, and data are only from publicly available sources and produced by the authorities or research institutions. The portal is under continuous development, with new themes and indicators, and improving spatial and temporal resolution.
Evaluation of Switching Power Amplifier Topology for Active Magnetic Bearings
Authors: Yang Kezhen , Hu Yefa , Guo Xinhua , Zhou Jian , Wu Huachun
Published: June 2021

Active magnetic bearings (AMBs) have led to great progress in the field of rotating machinery due to their many advantages, such as their non-contact and non-lubrication properties. As the key component of an AMB actuator, the switching power amplifier has an important impact on the performance of magnetic bearings and rotating machinery. In this paper, the topologies of switching power amplifiers for AMBs are introduced. The traditional half-bridge topology and two newly proposed topologies—the three-phase-half-bridge and neutralized-sharing-bridge topology—are analyzed and discussed. The volume, current output performance and cost of the power amplifier with different topologies are comprehensively evaluated, providing a theoretical basis and guidance for the selection and design of the topology of switching power amplifiers for AMBs under different conditions.
The Aromatase–Estrogen System in the Testes of Non-Mammalian Vertebrates
Authors: Rosati Luigi , Falvo Sara , Chieffi Baccari Gabriella , Santillo Alessandra , Di Fiore Maria Maddalena
Published: June 2021

Estrogens are important physiological regulators of testicular activity in vertebrates. Estrogen levels depend on the activity of P450 aromatase, the enzyme responsible for the irreversible conversion of testosterone into 17β-estradiol. Therefore, P450 aromatase is the key player in the aromatase–estrogen system. The present review offers a comparative overview of P450 aromatase activity in male gonads of amphibians, reptiles, and birds, with a particular emphasis on the functions of the aromatase–estrogen system in these organisms during their developmental and adult stages. The aromatase–estrogen system appears to be crucial for the sex differentiation of gonads in vertebrates. Administration of aromatase inhibitors prior to sexual differentiation of gonads results in the development of males rather than females. In adults, both aromatase and estrogen receptors are expressed in somatic cells, Leydig and Sertoli cells, as well as germ cells, with certain differences among different species. In seasonal breeding species, the aromatase–estrogen system serves as an “on/off” switch for spermatogenesis. In some amphibian and reptilian species, increased estrogen levels in post-reproductive testes are responsible for blocking spermatogenesis, whereas, in some species of birds, estrogens function synergistically with testosterone to promote spermatogenesis. Recent evidence indicates that the production of the aromatase enzyme in excessive amounts reduces the reproductive performance in avian species of commercial interest. The use of aromatase inhibitors to improve fertility has yielded suitable positive results. Therefore, it appears that the role of the aromatase–estrogen system in regulating the testicular activity differs not only among the different classes of vertebrates but also among different species within the same class.