bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of handrail height and knee joint support on sit-to-stand movement
Authors: Han Xiaolong , Xue Qiang , Yang Shuo , Li Ya , Zhang Shouwei , Li Min
Published: October 2022

Handrail height and knee joint support both significantly influence sit-to-stand (STS) movement. However, research on the associations between handrail height, knee joint support, and their cumulative effect on STS kinematics and changes in plantar pressure distribution during STS under different handrail heights and knee joint support is still unclear. The main objective of this study was to examine the influence of handrail height and knee joint support on the kinematics and the distribution of plantar pressure in healthy adults during STS. Twenty-six healthy adult subjects aged 23 to 58 years participated in this experiment. The subjects carried out STS movement experiments under 7 conditions: 6 experimental conditions of 3 different heights of handrail, with and without knee joint support, and 1 control condition of standing up naturally. The motions of the markers were recorded using cameras operating at 60 Hz, and total movement time, the percentage of movement time of each phase, trunk tilt angle, joint angle, plantar pressure, and the time from hindfoot to forefoot peak pressure were analyzed and compared. Handrail height significantly influences the percentage of movement time at phase I (P = .015) and the maximum trunk tilt angle (P < .05), knee joint support significantly influences the maximum trunk tilt angle and ankle angle (P = .033), and handrail height and knee joint support have an interaction on the time from hindfoot to forefoot peak pressure (P < .001). Subjects’ STS performance was improved with the use of assistant devices but showed particular improvement under the condition of with knee joint support when the handrail height was middle handrail.
Challenging Metastatic Melanoma to the Lung With p40 Expression: A Diagnostic Pitfall, Case Report
Authors: Thierry Sixte , Juberthie Bernard , Gyenes Cezar , Dramais-Marcel Dominique , Forest Fabien
Published: October 2022

p40 immunohistochemistry is a cornerstone of histopathological examination for non-small cell lung carcinoma. p40 is an isoform of p63 and is reported to be highly specific for the diagnosis of squamous cell carcinoma. Very rare pitfalls are reported for this antibody, and p40 is typically negative in melanoma. A 66-year-old patient was admitted for multiple hemorrhagic brain tumors evocative of secondary tumors. On imaging, a 26 mm lung tumor was detected, and a biopsy of the lung tumor was performed. The tumor was stained by melanic markers and diffusely stained by p40 and p63. Molecular analysis found a somatic p.Asn581Ser (c.1742A>G) point mutation in exon 15 of BRAF and a p.Arg80Ter (c.238C>T) germline variant of CDKN2A, a predisposing mutation to melanoma. This case report highlights the importance of clinical, pathologic, and molecular correlation.
JAK/STAT3 Signaling Activation Related to Distinct Clinicopathologic Features in Systemic ALK− Anaplastic Large Cell Lymphomas
Authors: Wang Jian-chao , Zhong Li-hua , Lin Wei-qing , Zhang Wen-fang , Xi Yan-feng , Liu Yue-ping , Zhu Qiong , Liu Wei , Zhu Wei-feng , Chen Yan-ping , Chen Gang
Published: October 2022

Systemic anaplastic lymphoma kinase (ALK)-negative anaplastic large cell lymphoma (ALCL) is a group of heterogenous CD30+ T-cell non-Hodgkin lymphomas. Previous studies have highlighted the importance of JAK/STAT3 signaling activation in the molecular pathogenesis of ALK− ALCLs. In the present study, we aimed to establish a potential relationship between JAK/STAT3 signaling activation and clinicopathologic features in ALK− ALCLs, and further recognize the heterogenous nature of these neoplasms. Immunohistochemistry staining of the phosphorylated-STAT3 (p-STAT3) and dual-specificity protein phosphatase 22 (DUSP22) gene rearrangement analysis were performed. Forty-five cases of ALK− ALCL were divided into 3 groups, including 9 DUSP22-rearranged ALCLs, 21 p-STAT3+ double-negative (DN) ALCLs (both ALK and DUSP22 rearrangement negative), and 15 p-STAT3− DN-ALCLs. Morphologically, p-STAT3+ DN-ALCLs exhibited sheet-like neoplastic cells and sometimes showed large pleomorphic cells scattered in a lymphocyte-rich background more frequently than those in other ALK− ALCLs subtypes. Phenotypically, the p-STAT3+ DN-ALCLs frequently expressed cytotoxic molecules, epithelial membrane antigen, and programmed death-ligand 1, whereas CD3 and CD5 expression was not observed. Clinically, patients with p-STAT3+ DN-ALCLs had a better prognosis than those with p-STAT3− DN-ALCLs. These observations suggest that p-STAT3+ DN-ALCLs represent a distinct subtype of ALK− ALCLs. Identifying ALK− ALCL subtypes by using p-STAT3 staining and DUSP22 rearrangement is a promising approach that may contribute to risk stratification and better treatment decisions in the future clinical practice.
Design and Use of a Pair of Computer-Designed Surgical Templates in Reduction of a Comminuted Zygomatic Arch Fracture
Authors: Lin Yuxin , Zhou Haihua , Lv Kun , Li Zhi , Li Zubing
Published: October 2022

Background:

Isolated depressed zygomatic arch fractures are often treated with closed reduction. Reduction is usually performed through the Gillies approach or Keen approach. comminuted zygomatic arch fractures generally require open reduction and fixation to achieve good results. This article describes how to use a pair of surgical templates to assist in the fixation of comminuted zygomatic arch fractures with absorbable plates.

Methods:

A pair of computer-designed surgical templates were applied to restore the main part of zygomatic arch. Placing a surgical template on the medial side of the zygomatic arch can provide a supporting force and improves the stability of the reduced bone fragments. The lateral template of zygomatic arch limits the excessive uplift of bone fragments.

Results and Discussion:

The operation was performed according to the predetermined procedure. Postoperative computed tomography showed satisfactory reduction effect. In conclusion, with the aid of surgical templates, the reduction and fixation of comminuted zygomatic arch fractures can be more easily performed using absorbable plates.
Total Resection of Cerebellopontine Angle Meningioma via Presigmoid Transmastoid Approach: An Otologist’s Perspective
Authors: Guo Fang , Zhang De-Jun , Fu Ze-Ming , Guo Ying-Yuan , Wan Yi-Ning , Tang Na , Guan Guo-Fang
Published: October 2022

Purpose:

Cerebellopontine angle meningiomas (CPAMs) are benign tumors that arise from the dura mater of the petrosal surface of the temporal bone, lateral to the trigeminal nerve. This study aimed to describe 1 case of CPAMs violating the mastoid and highlight the unique superiority of the presigmoid transmastoid approach for this type of CPAMs from an otologist’s perspective.

Methods:

One case of specific CPAMs treated by total resection via presigmoid transmastoid approach in otomicrosurgery was described.

Results:

A patient was referred for the left intracranial space-occupying lesion found in physical examination. Surgical resection via presigmoid transmastoid approach was performed and there was no sign of recurrence of tumor 2 years after the operation.

Conclusions:

Presigmoid transmastoid approach in otomicrosurgery is suitable for CPAMs invading the mastoid. It is suggested that neurosurgeons and ear surgeons should comprehensively analyze the type and extent of the tumor and flexibly adopt surgical methods to ensure it is the best for patients.
Edentulous Space Closure Using a Clear Aligner System After Alveolar Ridge Split Augmentation
Authors: Tsoukala Efthimia , Maroulakos Michael , Kamperos Georgios
Published: October 2022

Orthodontic tooth movement in adult edentulous, atrophic posterior mandibular alveolar ridges is a challenging task. In this case report, a young adult woman seeking an aesthetic orthodontic solution, presented with mandibular alveolar ridge atrophy due to a congenitally missing lower incisor. Alveolar ridge splitting technique using piezosurgery for bone augmentation was selected to minimize the risks of orthodontic movement in the atrophic edentulous space. Orthodontic corrections were planned and executed with a clear aligner system. The surgical and orthodontic interventions combined well together, addressing patients’ orthodontic concerns, with minimal intervention, least discomfort, and reduced treatment time.
Basement Membrane Changes of Myofiber and Fibrosis in Sternocleidomastoid Muscle of Congenital Muscular Torticollis
Authors: Gao Futang , Zeng Shuaidan , Tang Shengping , Ning Pei , Qiu Xin , Cai Ting , Tang Gen , Xiong Zhu
Published: October 2022

Objective:

To investigate the correlation between the features of basement membranes (BMs) of residual myofibers in the sternocleidomastoid muscle (SCM) and fibrosis of congenital muscular torticollis (CMT) in children, and to evaluate the relationship between BM changes and appearance of CMT.

Materials and Methods:

We reviewed the CMT patients from 2017 to 2018 and performed pathological studies. Forty resected specimens were stained by hematoxylin and eosin and Masson collagen staining. Immunohistochemical staining of collagen IV and laminin was also performed. Five adductor muscle specimens from patients with developmental dysplasia of the hip were used as the control group.

Results:

Hematoxylin and eosin staining revealed apparent interstitial fibrosis around residual myofibers in lesion specimens. However, the severity of fibrosis differed within the same samples. The average percent area of fibrous tissue in affected SCMs and controls were different significantly. Immunohistochemical staining of collagen IV and laminin showed these proteins were mostly expressed in the BM and vascular wall of affected SCM. However, BMs and myofibers from three different areas within the same SCM tissue exhibited significant differences in proteins expression.

Conclusions:

Therefore, the defective BMs are associated with myofiber and mesenchyme fibrosis in patients with CMT, which is crucial for understanding the histopathology of SCM.
Long-Term Effect of Intermediate Rhinoplasty in Unilateral Complete Cleft Lip Nasal Deformity
Authors: Park Joseph Kyu-hyung , Koo Hee Tae , Choi Kyeong Beom , Kim Sukwha , Chung Jee Hyeok
Published: October 2022

Background:

Intermediate rhinoplasties are performed during preschool to reduce the patients’ psychosocial burden. At our institution, limited dissection of the cartilages followed by suspension and interdomal sutures was performed through an alar rim incision on the cleft side to minimize the risk of iatrogenic nasal growth restriction. However, the long-term outcomes of “limited intermediate rhinoplasty” through skeletal growth are uncertain.

Materials and Methods:

A retrospective review of all unilateral complete cleft lip and/or palate patients who underwent definitive rhinoplasty was performed. To avoid the confounding effect of primary rhinoplasty, only the patients who did not receive primary rhinoplasty were included in the analysis. The maneuvers performed during definitive rhinoplasty were analyzed and compared between patients who underwent intermediate rhinoplasty and those who did not.

Results:

A total of 60 Korean patients (27 female and 33 male) underwent definitive rhinoplasty at the average age of 20.6 years old (17.1–25.5). Forty-three (71.6%) patients previously underwent intermediate rhinoplasty. A combination of 6 maneuvers was performed based on the deformity of each subunit (alar medialization, interdomal with suspension sutures, nostril sill depression correction, septoplasty, osteotomy, and hump rasping). The average number of maneuvers performed during definitive rhinoplasty was significantly higher in the intermediate group (3.31 versus 2.1, P=0.012). Alar medialization and nostril sill depression correction were more frequently performed in the intermediate group, while the frequencies of other maneuvers were not statistically different.

Conclusion:

While intermediate rhinoplasty improves the patients’ psychosocial well-being, the effects of “limited intermediate rhinoplasty” manipulating only the cartilages do not seem to last until skeletal maturity. A more comprehensive dissection allowing the release of the lower lateral cartilage in the hinge area along with septoplasty may be more effective in providing longer-lasting effects.
Effect of Bone-Borne Trans-Sutural Distraction Osteogenesis Therapy on the Cranial Base of Children With Midfacial Hypoplasia Due to Cleft Lip and Palate
Authors: Zhang Peiyang , Tong Haizhou , Chen Yujie , Zhou Binyi , Fang Lin , Zhao Zhenmin
Published: October 2022

Bone-borne trans-sutural distraction osteogenesis (TSDO) is widely used to treat midfacial hypoplasia in children with cleft lip and palate; however, its effects on the cranial base are still poorly understood. The authors aimed to study morphological changes in the cranial base after TSDO. Pre and postoperative computed tomography (CT) images of cleft lip and palate children with midfacial skeleton dysplasia who underwent TSDO were collected retrospectively, and their corresponding 3-dimensional models were measured. Results showed no significant change in the length of the anterior or posterior cranial fossa, but the length of the middle cranial fossa increased significantly. The anterior cranial base rotated upward with the sella turcica at the center, whereas the cranial base angle increased. The sphenoid bone exhibited morphological changes. Post-TSDO, the lateral plate of the pterygoid process increased in length. The angle of the 2 lateral plates of the pterygoid process, the greater wings of the sphenoid bone, and the smaller wings of the sphenoid bone decreased. Posterior inclination of the pterygoid process increased. Mean volume of the sphenoidal sinus increased postoperatively compared with the preoperative volume. Apparent changes in the cranial base after TSDO are primarily in the middle cranial fossa, manifesting as an increase in the sphenoid bone body length, expansion of the sphenoidal sinus volume, growth of the pterygoid process forward and downward, a decrease in the angle of both the greater and smaller wings of the sphenoid bone, and an increase in the posterior inclination of the pterygoid process.
Acrogenospora terricola sp. nov., a fungal species associated with seeds of pioneer trees in the soil seed bank of a lowland forest in Panama
Authors: Harrington Alison H. , Sarmiento Carolina , Zalamea Paul-Camilo , Dalling James W. , Davis Adam S. , Arnold A. Elizabeth
Published: October 2022

As currently circumscribed, Acrogenospora (Acrogenosporaceae, Minutisphaerales, Dothideomycetes) is a genus of saprobic hyphomycetes with distinctive conidia. Although considered common and cosmopolitan, the genus is poorly represented by sequence data, and no neotropical representatives are present in public sequence databases. Consequently, Acrogenospora has been largely invisible to ecological studies that rely on sequence-based identification. As part of an effort to identify fungi collected during ecological studies, we identified strains of Acrogenospora isolated in culture from seeds in the soil seed bank of a lowland tropical forest in Panama. Here we describe Acrogenospora terricola sp. nov. based on morphological and phylogenetic analyses. We confirm that the genus has a pantropical distribution. The observation of Acrogenospora infecting seeds in a terrestrial environment contrasts with previously described species in the genus, most of which occur on decaying wood in freshwater environments. This work highlights the often hidden taxonomic value of collections derived from ecological studies of fungal communities and the ways in which rich sequence databases can shed light on the identity, distributions and diversity of cryptic microfungi.
In silico investigation of the genus Campylobacter type VI secretion system reveals genetic diversity in organization and putative effectors
Authors: Robinson Luca , Liaw Janie , Omole Zahra , Corcionivoschi Nicolae , Hachani Abderrahman , Gundogdu Ozan
Published: October 2022

Bacterial type VI secretion systems (T6SSs) are contractile nanomachines that deliver proteinic substrates into target prokaryotic or eukaryotic cells and the surrounding milieu. The genus

Campylobacter

encompasses 39 recognized species and 13 subspecies, with many belonging to a group known as ‘emerging

Campylobacter

pathogens’. Within

Campylobacter

, seven species have been identified to harbour a complete T6SS cluster but have yet to be comparatively assessed. In this study, using systematic bioinformatics approaches and the T6SS-positive

Campylobacter jejuni

488 strain as a reference, we explored the genus-wide prevalence, similarity and make-up of the T6SS amongst 372 publicly available ‘complete’

Campylobacter

genomes. Our analyses predict that approximately one-third of

Campylobacter

species possess a T6SS. We also putatively report the first identification of a T6SS in four species: Campylobacter cuniculorum, Campylobacter helveticus, Campylobacter armoricus and

Campylobacter ornithocola

. The

Campylobacter

T6SSs cluster into three distinct organizations (I–III), of which two break down into further variants. Thirty T6SS-containing genomes were found to harbour more than one vgrG gene, with

Campylobacter lari

strain NCTC 11845 possessing five. Analysis of the

C. jejuni

Pathogenicity Island-1 confirmed its conservation amongst T6SS-positive

C. jejuni

strains, as well as highlighting its diverse genetic composition, including additional putative effector–immunity pairs (e.g. PoNe and DUF1911 domains). Effector–immunity pairs were also observed neighbouring vgrGs in several other

Campylobacter

species, in addition to putative genes encoding nucleases, lysozymes, ATPases and a ferric ATP-binding cassette uptake system. These observations highlight the diverse genetic make-up of the T6SS within

Campylobacter

and provide further evidence of its role in pathogenesis.
Application of a Multiplicative Cascade Model to Detect the Early Signs of SARS-CoV-2 Infection Using Heart Rate Data
Authors: Heath Rachel
Published: October 2022

Background

Wrist-worn devices can keep track of a person’s daily health status, including those likely to become infected with the SARS-CoV-2 virus. Technological solutions using mobile devices are being developed to predict the time course of COVID-19.

Objective

In this proof-of-concept study, we use heart rate data to detect the first sign of infection in people who have been diagnosed with COVID-19 and to monitor the time-course of the illness.

Methods

The heart-rate data were analysed using a multiplicative cascade driven by a Gaussian process. This provides two parameters, mean and standard deviation, which when combined with similar parameters estimated from control series, provide a Health Index.

Results

For 90% of 31 cases, the Health Index tracked COVID-19 infection with the virus and subsequent recovery. The first-sign of COVID-19 was detected on average nine days before symptoms were reported.

Conclusions

Early detection of COVID-19 may lead to a reduction in the spread of the virus. The Heath Index’s potential use for the early detection of complications arising from Long COVID would be an important innovation.
Transcription, structure, and organoids translate time across the lifespan of humans and great apes
Authors: Charvet Christine J. , Ofori Kwadwo , Falcone Carmen , Rigby-Dames Brier A.
Published: October 2022

How the neural structures supporting human cognition develop and arose in evolution is an enduring question of interest. Yet, we still lack appropriate procedures to align ages across primates, and this lacuna has hindered progress in understanding the evolution of biological programs. We generated a dataset of unprecedented size consisting of 573 time points from abrupt and gradual changes in behavior, anatomy, and transcription across human and 8 non-human primate species. We included time points from diverse human populations to capture within-species variation in the generation of cross-species age alignments. We also extracted corresponding ages from organoids. The identification of corresponding ages across the lifespan of 8 primate species, including apes (e.g., orangutans, gorillas) and monkeys (i.e., marmosets, macaques) reveal that some biological pathways are extended in humans compared with some non-human primates. Particularly, the human lifespan is unusually extended relative to studied nonhuman primates demonstrating that very old age is a phase of life in humans that does not map to other studied primate species. More generally, our work prompts a reevaluation in the choice of a model system to understand aging given very old age in humans is a period of life with a clear counterpart in great apes.

Significance Statement

What is special about the duration of human development and aging has been an enduring source of interest. A significant hurdle in identifying which biological programs are unusually extended in humans is the lack of standardized approaches with which to align ages across species. We harnessed temporal variation in behavior, transcription, and anatomy to align ages across the lifespan of primates. These data reveal which biological programs are conserved, and which are modified. Harnessing time points across scales of study guides the choice of model systems to understand disease progression, and can be used to enhance care of great apes, many of which are critically endangered.
Chromosome-level genome assembly ofTorreya grandisprovides insights into the origin and evolution of gymnosperm-specific sciadonic acid biosynthesis
Authors: Lou Heqiang , Song Lili , Li Xiaolong , Chen Weijie , Gao Yadi , Zheng Shan , Fei Zhangjun , Sun Xuepeng , Wu Jiasheng
Published: October 2022

Species in genusTorreyaare nut trees that produce dry fruits with a wide assortment of functions. Here, we report the 19-Gb chromosome-level genome assembly ofT. grandis.The genome is shaped by an ancient whole genome duplication and recurrent LTR retrotransposon bursts. Comparative genomic analyses reveal key genes involved in reproductive organ development, cell wall biosynthesis and seed storage. Two genes encoding a C18Δ9-elongase and a C20Δ5-desaturase are identified inT. grandisto be responsible for sciadonic acid biosynthesis and both are present in diverse plant lineages except angiosperms. We demonstrate that the histidine-rich boxes of the Δ5-desaturase are crucial for its catalytic activity. Methylome analysis reveals that methylation valleys of theT. grandisseed genome harbor genes associated with important seed activities, including cell wall and lipid biosynthesis. Moreover, seed development is accompanied by DNA methylation changes that possibly fuel energy production. This study provides important genomic resource for gymnosperms and unravels key enzymes for biosynthesis of sciadonic acid as a hallmark metabolite of gymnosperms.
Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy
Authors: Pujol Gualdo Natàlia ,   Estonian Biobank Research Team, Mägi Reedik , Laisk Triin
Published: October 2022

Ectopic pregnancy is an important cause of maternal morbidity and mortality worldwide. To better understand the genetic risk factors underlying this pregnancy complication, we conduct a GWAS meta-analysis and identify two genome-wide significant loci on chromosomes 1 (rs4971091, p=5.32×10−9) and 10 (rs11598956, p=2.41×10−8). Follow-up analyses propose MUC1, an epithelial glycoprotein with an important role in barrier function, as the most likely candidate for the association on chromosome 1. We also characterise the phenotypic and genetic correlations with other phenotypes, identifying a genetic correlation with smoking and diseases of the (genito)urinary and gastrointestinal system, and phenotypic correlations with various reproductive health diagnoses, reflecting the previously known epidemiological associations.
The extracellular matrix differentially directs myoblast motility in distinct forms of muscular dystrophy
Authors: Long Ashlee M. , Kwon Jason M. , Lee GaHyun , Reiser Nina. L. , Vaught Lauren. A , O’Brien Joseph G. , Page Patrick G.T. , Hadhazy Michele , Reynolds Joseph C. , Crosbie Rachelle H. , Demonbreun Alexis R. , McNally Elizabeth M.
Published: October 2022

Extracellular matrix (ECM) pathologic remodeling underlies many fibrotic disorders, including muscular dystrophy. Tissue decellularization removes cellular components while leaving behind ECM components. We generated “on-slide” decellularized tissue slices from genetically distinct dystrophic mouse models. The ECM of dystrophin-and sarcoglycan-deficient muscles had marked thrombospondin 4 deposition, while dysferlin-deficient muscle had excess decorin. Annexins A2 and A6 were present on all dystrophic decellularized ECMs, but annexin matrix deposition was excessive in dysferlin-deficient muscular dystrophy. Adeno-associated viral expression of annexin A6 specifically in muscle resulted in annexin A6 deposition throughout the ECM, indicating muscle as a source of this ECM protein. C2C12 myoblasts seeded onto decellularized matrices displayed differential myoblast mobility. Dystrophin-deficient decellularized matrices inhibited myoblast mobility while dysferlin-deficient decellularized matrices enhanced myoblast movement. Myoblasts treated with recombinant annexin A6 increased mobillity similar to that seen on dysferlin-deficient decellularized matrix. These findings demonstrate specific fibrotic signatures elicit effects on myoblast activity.

TEASER

Fibrosis in muscular dystrophy has differential effects on myoblasts

HIGHLIGHTS

Spatial architecture and composition of the ECM differ across genetically distinct forms of muscular dystrophy, especially with respect to Annexin A6 protein deposition

Matrix from dystrophin-mediated muscular dystrophy inhibits myoblast movement

Matrix from dysferlin-deficient muscular dystrophy promotes myoblast motility

Annexin A6 was sufficient to enhance myoblast motility
Lipid peroxidation increases membrane tension, Piezo1 gating and cation permeability to execute ferroptosis
Authors: Hirata Yusuke , Cai Ruiqi , Volchuk Allen , Steinberg Benjamin E. , Matsuzawa Atsushi , Grinstein Sergio , Freeman Spencer A.
Published: October 2022

The ongoing metabolic and microbicidal pathways that support and protect cellular life generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells express peroxidases, antioxidant enzymes that catalyze the reduction of oxidized biomolecules. Glutathione peroxidase 4 (GPX4) is the major hydroperoxidase specifically responsible for reducing lipid peroxides; this homeostatic mechanism is essential and its inhibition causes a unique type of lytic cell death, ferroptosis. The mechanism(s) that lead to cell lysis in ferroptosis, however, are unclear. We report that the lipid peroxides formed during ferroptosis accumulate preferentially at the plasma membrane. Oxidation of surface membrane lipids increased tension on the plasma membrane and led to the activation of Piezo1 and TRP channels. Oxidized membranes thus became permeable to cations, ultimately leading to gain of cellular Na+and Ca2+concomitant with loss of K+. These effects were reduced by deletion of Piezo1 and completely inhibited by blocking cation channel conductance with ruthenium red or 2-aminoethoxydiphenyl borate (2-APB). We also found that the oxidation of lipids depressed the activity of the Na+/K+-ATPase, exacerbating the dissipation of monovalent cation gradients. Preventing the changes in cation content attenuated ferroptosis. Together, our study establishes that increased membrane permeability to cations is a critical step in the execution of ferroptosis and identifies Piezo1, TRP channels and the Na+/K+-ATPase as targets/effectors of this type of cell death.
Pulling back the curtain of environmental accountability: How boundaries shape environmental identities in the SKI industry
Authors: Gamble Edward , Caton Gary
Published: October 2022

Purpose

This paper aims to explore the important role boundaries play in back-office framing of environmental engagement. This is of particular interest because it is not clear how organizations in an industry without standardized environmental reporting navigate their boundaries behind the scenes and why they engage with the environment the way they do. This element of their environmental identity offers important insights into the emergence of sustainability reporting.

Design/methodology/approach

Guided by Miles and Ringham (2019) the authors conduct an ethnography of the Montana ski industry. The ethnography includes extensive on-site observations at nine Montana ski areas and interviews with 16 ski area executives, two regulators and a land development executive.

Findings

The authors find three key boundaries – accountability structure, degree of regulatory burden and impact measurement approach – that shape the back-office economic and environmental framing of ski executives (Goffman, 1959, 1974). From these back-office frames the authors identify four front-office cultural performances – community ecosystem, quantitative ownership, approval seeking and advocacy platform – that represent the environmental engagement strategies at these resorts.

Practical implications

Understanding the relationships between boundaries and environmental engagement is an important step in developing appropriate industry-wide environmental accountability and sustainability expectations. The study’s findings extend to other industries that are both highly dependent on the environment and are in the early stages of developing environmental reporting standards.

Originality/value

Ski resorts operate in an industry that is impacted by changes in the natural environment. The authors chronicle the process by which boundaries lead to framing which leads to environmental engagement in this weather-dependent industry. The authors explain the process of environmental identity building, the result of which both precedes environmental reporting and puts such reporting into context. In this sense, the authors show how boundaries are set and maintained in the ski resort industry, and how fundamental these boundaries are to the development of individual companies' environmental engagement strategies.
Simulating risk management strategies for specialized farming systems: the potential impact of the EU income stabilization tool
Authors: Zinnanti Cinzia , Coletta Attilio , Torrigiani Michele , Severini Simone
Published: October 2022

Purpose

This study assesses the potential impact of the European Income Stabilization Tool (IST – a whole farm income risk management [RM] tool) within a farm cooperative specializing in vineyards and operating in a small area of production. The authors assess the conditions under which IST could improve the well-being of the associated farmers and, at the same time, improve financial sustainability. Financial aspects are of particular relevance since the characteristics of the cooperative cause the management of the tool to become potentially risky.

Design/methodology/approach

The analysis relies on a balanced panel dataset to report the production and economic characteristics of individual associated farms. This is the basis for simulating the implementation of the IST as described in the current European regulation. The expected utility approach is then used to assess the potential impact on farmers' well-being under different levels of risk aversion and premiums. The analysis of the IST annual cash flow allows for an accurate assessment of its financial sustainability.

Findings

The results suggest that the IST can improve farmers' well-being under plausible levels of risk aversion and premiums, making most farmers willing to support its implementation. Furthermore, the tool could be financially sustainable even if implemented in a specialized and geographically concentrated group of farms. In addition, the results suggest that the use of strategies such as the IST could help cope with negative annual balances by treating the financial sustainability of the fund.

Originality/value

The analysis adds to previous research on the IST by accounting for farmers' risk aversion. Furthermore, it is the first analysis that simulates the implementation of this tool in a sector-specific and concentrated group of farms. The results provide useful evidence for those subjects planning to implement the IST in small and specialized farming systems.
Motivations for sharing personal information and self-disclosure in public and private Facebook groups of mentally ill people
Authors: Rothschild Nava , Aharony Noa
Published: October 2022

Purpose

This study explores the motivations for sharing personal information and self-disclosure by mentally ill people in public and private Facebook groups. The purpose of the self-disclosure comparison between public and private groups is to understand how mentally ill people use different kinds of online communication channels in order to advance their goals and needs concerning their illness.

Design/methodology/approach

The study was carried out using questionnaires distributed in Facebook groups for people with mental illnesses. A total of 123 full and valid questionnaires were received. Statistical analysis was performed on the data.

Findings

Findings revealed that there are no significant differences between public and private groups concerning motivations for self-disclosure and that both types of groups create a safe and supportive place for mentally ill people. However, findings suggest that participants in public groups tend to display higher social involvement than those who participate in private groups.

Originality/value

This is a path breaking study on the entire subject of discourse of people with mental illnesses in private Facebook groups and its importance is derived from this. The study clarified and emphasized the importance of the sense of belonging to a community. Moreover, findings encourage people with mental illnesses to make use of social media channels to meet their social and personal needs.
Ethnic minority and their knowledge about their human health rights: evidence from a national survey in Peru
Authors: Uyen-Cateriano Angela , Visconti-Lopez Fabriccio J. , Cabanillas-Ramirez Cielo , Morocho-Pinedo Milene , Benites-Zapata Vicente A. , Raa-Ortiz Daniel , Herrera-Añazco Percy
Published: October 2022

Purpose

This study aims to evaluate the association between ethnic minority membership and their knowledge about their human health rights in Peru.

Design/methodology/approach

A secondary analysis of the National Health User Satisfaction Survey 2015–2016 was conducted using an analytical cross-sectional design. Participants who spoke Quechua, Aymara, Awajun, Bora or a language other than Spanish aged 15 year were considered as a racial minority. The question “Do you know that by law you have health rights?” was applied to incorporate knowledge on health rights. Generalized linear models of the Poisson distribution were used to calculate crude prevalence ratio and adjusted prevalence ratio. A total of 3,721 responses were included in the analysis.

Findings

The average age was 38.3 year, and 26.6% were males. The prevalence of belonging to an ethnic minority was 7.7%, and 27.6% of the participants did not know about their health rights. An association was found in the adjusted regression analysis between belonging to an ethnic minority and a greater probability of not knowing human health rights.

Originality/value

The value of the works lies in one in four participants who did not know he had health rights by law. Belonging to an ethnic minority was associated with not knowing about having human health rights.
From real-time visibility to operational benefits – tensions on unfinished paths
Authors: Wycislak Slawomir
Published: October 2022

Purpose

Visibility is the need of the hour for each organization involved in the supply chain, and scholars have made few previous efforts to understand patterns driving visibility in transportation platforms. However, many companies have not been able to achieve sufficient levels of practical implementation across the supply chain. Therefore, this study focuses on exploring, why the real-time visibility transportation platforms fail to operationalize.

Design/methodology/approach

This study utilizes action research as a methodology for pragmatism to understand supply chain professionals' viewpoint regarding the operationalization of real-time visibility. The research addresses a complex transportation network of a fast-moving consumer goods company. Wherein, both a greater need for visibility and improvements are also more challenging.

Findings

Tensions amongst complementors, the platform owner, and the Control Tower of a focal company explain the different impacts of freight forwarders and own fleet carriers on shipment compliance. Integrating subcontractors is a cost-intensive practice for complementors that increases asymmetry and reduces co-created value. The willingness of freight forwarders to exert control contributes to tension competition versus collaboration.

Research limitations/implications

The model identifies the dynamics that explain how managers can navigate the tension over time by controlling contradictory loops driving shipment compliance. Findings can help managers develop plans, conduct pilots, and collaborate to unlock value from real-time visibility. The research findings can be informative for the European Union bodies and help work out a policy that reduces the asymmetry of benefits and contribute to the more sustainable development of digital industrial platforms.

Originality/value

The contribution lies in (1) providing a study of the factors affecting achieving real-time visibility, (2) distinguishing complementors (3) identifying tensions amongst complementors and platform owner as critical for successful platform deployment, (4) conceptualizing a pattern of behavior emerging amongst the platform partners and (5) outlining avenues for future research.
Analysing the linkage between total factor productivity and tourism growth in Latin American countries
Authors: Tzeremes Panayiotis
Published: October 2022

Purpose

The study aims to investigate the nexus between total factor productivity and tourism growth in Latin American countries for time series data from 1995 to 2017.

Design/methodology/approach

Using the extension of the Granger noncausality test in the nonlinear time-varying of Ajmi et al. (2015), the study points out the interconnectedness between the variables during the period.

Findings

The study found nonlinear causality between the variables. Particularly, studying the conclusions for the time-varying Granger causality fashion, it can be noticed that the one-way causality from total factor productivity to tourism growth is obtained for Argentina, Bolivia, Brazil, Uruguay and Venezuela, while the vice versa is confirmed for Chile, Ecuador and Nicaragua. Lastly, the study dissected the plots of the curve causality.

Practical implications

In view of the results, some crucial policy implications could be suggested, such as, under certain circumstances and as an exceptional case, the use of policy instruments such as targeted investment, marketing and the support of tourism organizations focused on driving a tourism-led-based productivity and/or tourism programs and projects.

Originality/value

The current work is distinguished from the existing body of understanding in several substantial directions. This work explores, for the first time, the linkages between the total factor productivity index and tourism growth for Latin American countries. No single attempt has been known to investigate this interaction by using nonlinear causality, and this study determines the shape of the curve between the total factor productivity index and tourism growth for each country.
Deontic technology perceptions: a complementary view to instrumental perspectives on technology acceptance and use
Authors: Perrigino Matthew B. , Dunford Benjamin B. , Boss R. Wayne , Troup Matt , Boss David S.
Published: October 2022

Purpose

For decades, organizational research has primarily considered instrumental technology perceptions (ITP) – emphasizing how technology impacts the personal interests of end users themselves – to understand technology acceptance. The authors offer a complementary paradigm by introducing deontic technology perceptions (DTP), defined as the degree to which individuals believe that the technology they use is beneficial to other individuals beyond themselves (e.g. beneficial to customers).

Design/methodology/approach

The authors collected quantitative survey-based data from three different hospitals located in the United States. On the basis of conservation of resources theory, the authors investigated whether both DTP and ITP were associated with improved work-related well-being.

Findings

Two pilot studies (n = 161 and n = 311 nurses) substantiated our DTP conceptualization. Our primary study (n = 346 nurses) found support for the association between DTP and improved work-related well-being. Evidence for the relationship between ITP and work-related well-being was mixed and the authors did not find a statistically significant interaction between DTP and ITP.

Originality/value

The authors build on decades of research on technology acceptance by complementing it with our deontic perspective. Our work demonstrates that technology users pay attention and react meaningfully to how their use of technology impacts not only themselves but also external parties like patients, customers and members of the general public.
Researchers' perception and response to the open access resources (OAR) in higher learning institutions of Tamil Nadu, India
Authors: Mangai Gunasekaran , Ganesan Perumal
Published: October 2022

Purpose

The purpose of this study is to report the results of a survey conducted at Bharathidasan and Alagappa Universities to determine the research scholars' awareness, use of Open Access (OA) resources, reasons for using, impact of OA on the research scholars' research, satisfaction and problems faced.

Design/methodology/approach

In this study, a self-assessed questionnaire was developed to collect data from the research scholars pursuing their research degrees from Bharathidasan and Alagappa Universities of Tamil Nadu, India. A total of 400 research scholars from various disciplines responded were used for analysis.

Findings

The results indicated that the majority of research scholars aware of few OA resources to a large extent and afraid to redistribute the sources as they fear of copyright issues. Easy to use, more informative and global research at one place were the major reasons for accessing the resources. The research scholars were aware of OA features and OA's impact such as freedom to use, modify, resources available with source code, reliability, self-archiving, quick publishing, more citations etc. Delay in downloading and lack of computer terminals to access the resources were the major issues faced by the research scholars. On the whole, the researchers are considering OA model as an alternative to business model and expect the university librarians to promote and enhance the accessibility of OA resources.

Practical implications

The outcomes of the results will enable the librarians and authorities in universities to formulate appropriate decisions to remove the issues faced by the research scholars and develop a framework for new literacy instructions.

Originality/value

The study undertaken is new to the Indian continent and the Tami Nadu state in particular. The findings of the study will be useful to improve the awareness level and use of OA resources effectively.
Historiography and Constitutional Adjudication
Authors: Partlett William
Published: October 2022

Lawyers and judges often use history in constitutional adjudication to provide context for constitutional interpretation. But there is debate about the extent to which historiography – the critical study of how history is written, developed by professional historians – is relevant to constitutional adjudication. This article argues that historiography has little relevance to constitutional reasoning grounded on historic legal sources such as court cases or legislation. But when constitutional reasoning relies on non‐legal, general historical sources, historiography provides important insights. Arguments based on general historical sources – particularly originalist ones – can and should be critiqued on historiographical grounds. These methods show that general historical sources are unlikely to generate precise and objective constitutional meaning but can be used to develop and constrain many constitutional arguments, including those concerning constitutional practice, purpose, or values. Historiographic methods are important for lawyers and judges seeking to critique or make constitutional arguments grounded on general history.
Association between patient‐reported social, behavioral, and health factors and emergency department visits in high‐risk VA patients
Authors: Greene Liberty , Maciejewski Matthew L. , Grubber Janet , Smith Valerie A. , Blalock Dan V. , Zulman Donna M.
Published: October 2022

Research Objective

To identify patient‐reported social risk, behavioral, and health factors associated with emergency department (ED) utilization in high‐risk Veterans Affairs (VA) patients.

Data Sources

Patient survey, VA, Medicare data.

Study Design

Prospective cohort study using multivariable logistic regression to identify patient‐reported factors associated with all‐cause and ambulatory care sensitive condition (ACSC)‐related ED visits among VA patients at high risk for hospitalization or death.

Data Extraction Methods

Patient‐reported measures derived from a 2018 survey sent to 10,000 VA patients; clinical and demographic characteristics derived from VA data; ED visits derived from VA and Medicare claims.

Principal Findings

Among 4680 survey respondents, 52.5% and 16.3% experienced an all‐cause or ACSC‐related ED visit in the following year, respectively. An ED visit was more likely among individuals with functional status limitations (6.0% points (Confidence Interval [CI] 0.017–0.103)) and transportation barriers (5.2% points [CI 0.005–0.099]). An ACSC‐related ED visit was more likely among individuals with functional status limitations (3.2% points [CI 0.003–0.062]) and self‐rated poorer health (7.4% points (CI 0.030–0.119) poor; 6.2% points (CI 0.029–0.096) fair; 4.1% points (CI 0.009–0.073) good; compared with excellent/very good).

Conclusions

Patient‐reported factors not present in most electronic health records were significantly associated with future ED visits in high‐risk VA patients.
Socially responsible human resource management and employee performance: The roles of perceived external prestige and employee human resource attributions
Authors: Lee Byron Y. , Kim Tae‐Yeol , Kim Sunghoon , Liu Zhiqiang , Wang Ying
Published: October 2022

Drawing on social information processing theory, this study examines the pathway by which socially responsible human resource management (SRHRM), which links HR management practices to the corporate social responsibility activities of firms, affects job performance. Two‐wave multi‐source data supports the indirect effect of SRHRM on employee job performance through perceived external prestige and organizational identification. In addition, various types of employee HR attributions (i.e., employee well‐being, employee exploitation, and industry HR attribution) significantly moderates the relationship between SRHRM and perceived external prestige in different ways. These findings expand our understanding of the relationship between SRHRM and employee job performance and the role of employee HR attributions in complementing or supplementing such relationships.