bluuebunny/crossref_metadata_2025 huggingface dataset:
A Review of Microfluidic Detection Strategies for Heavy Metals in Water
Authors: Lace Annija , Cleary John
Published: March 2021

Heavy metal pollution of water has become a global issue and is especially problematic in some developing countries. Heavy metals are toxic to living organisms, even at very low concentrations. Therefore, effective and reliable heavy metal detection in environmental water is very important. Current laboratory-based methods used for analysis of heavy metals in water require sophisticated instrumentation and highly trained technicians, making them unsuitable for routine heavy metal monitoring in the environment. Consequently, there is a growing demand for autonomous detection systems that could perform in situ or point-of-use measurements. Microfluidic detection systems, which are defined by their small size, have many characteristics that make them suitable for environmental analysis. Some of these advantages include portability, high sample throughput, reduced reagent consumption and waste generation, and reduced production cost. This review focusses on developments in the application of microfluidic detection systems to heavy metal detection in water. Microfluidic detection strategies based on optical techniques, electrochemical techniques, and quartz crystal microbalance are discussed.
The Problem with ‘Microbiome’
Authors: Donachie Stuart P. , Fraser Claire J. , Hill Ethan C. , Butler Marguerite A.
Published: March 2021

The term “microbiome” is currently applied predominantly to assemblages of organisms with 16S rRNA genes. In this context, “microbiome” is a misnomer that has been conferred a wide-ranging primacy over terms for community members lacking such genes, e.g., mycobiome, eukaryome, and virome, yet these are also important subsets of microbial communities. Widespread convenient and affordable 16S rRNA sequencing pipelines have accelerated continued use of such a “microbiome”, but at what intellectual and practical costs? Here we show that the use of “microbiome” in ribosomal gene-based studies has been egregiously misapplied, and discuss potential impacts. We argue that the current focus of “microbiome” research, predominantly on only ‘bacteria’, presents a dangerous narrowing of scope which encourages dismissal and even ignorance of other organisms’ contributions to microbial diversity, sensu stricto, and as etiologic agents; we put this in context by discussing cases in both marine microbial diversity and the role of pathogens in global amphibian decline. Fortunately, the solution is simple. We must use descriptive nouns that strictly reflect the outcomes attainable by the methods used. “Microbiome”, as a descriptive noun, should only be used when diversity in the three recognized domains is explored.
Variation of Efficacy of Filtering Face Pieces Respirators over Time in a Dental Setting: A Pilot Study
Authors: Checchi Vittorio , Montevecchi Marco , Checchi Luigi
Published: March 2021

Since aerosol continuously persists in dental settings, where different procedures and patients come in succession, the use of oronasal masks is highly recommended. Among them, respirators known as Filtering Face Pieces (FFP) show a protective superiority compared to surgical masks. Even concerning respirators classified as non-reusable, it is not known how many hours of use are necessary to compromise their filtering capacity. The aim of this study is to investigate the variations of filtering capacity of an FFP2 respirator over time, in order to safely optimize the timing of its use. Five respirators were worn by the same operator during clinical activity for different usage times (8, 16, 24, 32, 40 h), and one respirator was kept unused. All respirators underwent a bacterial filtration efficacy (BFE) test. T-test for paired data with Bootstrap technique and Wilcoxon test for paired data compared BFE values of the five tested FFP2s respectively at each time, and the areas with the corresponding values of the control respirator (FFp2-F). A generalized linear mixed effect model (GLM) was applied considering type of respirator and time as fixed effects and intercept as random effect. No significant statistical differences were present in the BFE of each time. Data obtained by the present study highlight the important ability of FFP2s to maintain their BFE over time, suggesting a long lasting protective function.
Investigation on the Mechanism and Parametric Description of Non-Synchronous Blade Vibration
Authors: Zhang Mingming , Hou Anping , Han Yadong
Published: March 2021

In order to explore the mechanism during the process of the non-synchronous vibration (NSV), the flow field formation development is investigated in this paper. Based on the fluid–structure interaction method, the vibration of rotor blades is found to be in the first bending mode with a non-integral order (4.6) of the rotation speed. Referring to the constant inter blade phase angle (IBPA), the appearances of frequency-locking and phase-locking can be identified for the NSV. A periodical instability flow emerges in the tip region with the mixture of separation vortex and tip leakage flow. Due to the nonlinearities of fluid and structure, the blade vibration exhibits a limit cycle oscillation (LCO) response. The separation vortex presenting a spiral structure propagates in the annulus, indicating a pattern as modal oscillation. A flow induced vibration is initiated by the spiral vortex in the tip. The large pressure oscillation caused by the movement of the spiral vortex is regarded as a main factor for the presented NSV. As the oscillation of blade loading occurs with blade rotating pass the disturbances, the intensity of the reverse leakage flow in adjacent channels also plays a crucial role in the blade vibration.
Bounds on the Lifetime Expectations of Series Systems with IFR Component Lifetimes
Authors: Rychlik Tomasz , Szymkowiak Magdalena
Published: March 2021

We consider series systems built of components which have independent identically distributed (iid) lifetimes with an increasing failure rate (IFR). We determine sharp upper bounds for the expectations of the system lifetimes expressed in terms of the mean, and various scale units based on absolute central moments of component lifetimes. We further establish analogous bounds under a more stringent assumption that the component lifetimes have an increasing density (ID) function. We also indicate the relationship between the IFR property of the components and the generalized cumulative residual entropy of the series system lifetime.
A Study on the Power Reserve of Distributed Generators Based on Power Sensitivity Analysis in a Large-Scale Power System
Authors: Kim Dongmin , Park Jung-Wook , Lee Soo Hyoung
Published: March 2021

Converter-based generators (CBGs) that use renewable energy sources (RESs) are replacing traditional aging coal and nuclear power generators. Increasing the penetration of CBGs into the entire power generation process reduces both the inertia constant of the power system and the total amount of power reserves. Additionally, RESs are very intermittent and it is difficult to predict changes in them. These problems, due to CBGs using RESs, pose new challenges to net–load balancing. As a solution, this paper proposes a virtual multi-slack (VMS) droop control that secures the stability and efficiency of system operation by controlling the output of CBGs distributed in various regions. The VMS droop control makes it possible to increase the inertia constant of the power system and to respond quickly and appropriately to load changes through the proposed VMS droop control based on power sensitivity. It is also proposed that the process selects proper power reserves of CBGs for stable VMS droop control. To verify the effectiveness of the proposed VMS droop control and the proper power reserve selection method for CBGs, several case studies were performed using a real Korean power system.
Increasing Access to Electricity: An Assessment of the Energy and Power Generation Potential from Biomass Waste Residues in Tanzania
Authors: Aslam Zahida , Li Hu , Hammerton James , Andrews Gordon , Ross Andrew , Lovett Jon C.
Published: March 2021

Tanzania has a high rural population, of which many rely on off-grid diesel generators to produce electricity. The focus of this paper is to assess if the waste biomass residues in Tanzania have sufficient energy potential to produce renewable electrical energy for small-scale electricity generation using off-grid diesel generators coupled with anaerobic digestion (AD) and/or gasification. The gaseous fuel produced can then be used to substitute diesel fuel used in small-scale dual fuel diesel gen-sets; thus, providing more affordable electricity whilst reducing dependency on fossil fuels. The biomass waste streams estimated are those arising from agriculture, forestry, livestock, and urban human waste. To answer this question, the energy potentials of each of these biomass waste streams are quantified, followed by further calculations to determine the electricity generation capacity per stream based on overall efficiencies of 10 and 25%. The results show that combined these waste streams have an energy potential of 385 PJ (for the base year of 2018) generated from 26,924 kilotonnes (kt). Collectively, these residues can produce at least 1.2 times the electricity generated nationally in 2018 using AD and gasification coupled with a diesel gen-set engine.
Facile Synthesis of Lanthanum Strontium Cobalt Ferrite (LSCF) Nanopowders Employing an Ion-Exchange Promoted Sol-Gel Process
Authors: Rahayu Sri , Fatah Adi Ab , Kale Girish M.
Published: March 2021

The perovskite nanopowders of lanthanum strontium cobalt ferrite (LSCF) have been synthesized using the alginate mediated ion-exchange process. This perovskite-based material is a promising cathode for intermediate-temperature solid oxide fuel cells (IT-SOFCs) due to its high electrical conductivity, low polarizability, high catalytic activity for oxygen reduction, enhanced chemical stability at an elevated temperature in high oxygen potential environment and high compatibility with the ceria based solid electrolytes. Phase pure LSCF 6428, LSCF 6455, and LSCF 6482 corresponding to La0.6Sr0.4Co0.2Fe0.8O3-δ, La0.6Sr0.4Co0.5Fe0.5O3-δ, and La0.6Sr0.4Co0.8Fe0.2O3-δ, respectively were successfully synthesized. The simultaneous thermal analysis (DSC-TGA) and XRD were used to determine the optimum calcination temperature for the dried ion-exchanged beads. Single phase nanopowders of LSCF (6428, 6455, and 6482) have been successfully prepared at a calcination temperature of 700 °C. The TGA analysis showed that every ton of LSCF-ALG dried beads can potentially yield 360 kg of LSCF nanopowders suggesting a potential for scaling-up of the process of manufacturing nanopowders of LSCF.
Penalty Electricity Price-Based Optimal Control for Distribution Networks
Authors: Pang Qingle , Ye Lin , Gao Houlei , Li Xinian , Zheng Yang , He Chenbin
Published: March 2021

With the integration of large-scale renewable energy and the implementation of demand response, the complexity and volatility of distribution network operations are increasing. This has led to the inconsistency between the actual net power consumption of power users and their optimal dispatching orders. As a result, the distribution networks cannot operate according to their optimization strategy. The study proposed a penalty electricity price mechanism and the optimal control method based on this electricity price mechanism for distribution networks. First, we established the structure of the distribution network optimal control system. Second, aiming at the actual net power consumption (including power generation and consumption) of power users tracking their dispatching orders, we established a penalty electricity price mechanism. Third, we designed an optimal control strategy and process of distribution networks based on the penalty electricity price. Finally, we verified the proposed method by taking the IEEE-33 node system as an example. The verification results showed that the penalty electricity price could effectively limit the net power consumption fluctuations of power users to achieve optimal control of distribution networks.
Review on Dynamic Simulation of Wind Diesel Isolated Microgrids
Authors: Sebastián Rafael
Published: March 2021

Wind diesel isolated microgrids (WDIMs) combine wind turbine generators (WTGs) with diesel generators (DGs) to supply electricity to remote consumers. WDIMs are low-inertia isolated power systems where large system frequency and voltage variations occur. WDIM dynamic modeling allows short-term simulations to be performed and detailed electrical variable transients to be obtained so that the WDIM power quality and stability can be tested. This paper presents a literature review about WDIM dynamic simulation. The review classifies articles according to factors such as the different WDIM operation modes (diesel only, wind–diesel and wind only) simulated, the types of WTGs used in the WDIM (constant- and variable-speed types), or the use of different short-term energy storage technologies (batteries, ultracapacitors, flywheels) to improve the WDIM power quality, stability and reliability. Papers about the dynamic simulation of related isolated microgrids are also reviewed. Finally, as an example of WDIM dynamic simulation, a WDIM with one WTG, one DG, load and a discrete dump load (DL) is modeled and simulated. The WDIM response to variations of wind speed and load consumption is shown by graphs of the main electrical variables. The simulations show how the DL is used to improve the WDIM stability and reliability.
The Influence of Milk Standardization on Chemical Composition, Fat and Protein Recovery, Yield and Sensory Properties of Croatian PGI Lički Škripavac Cheese
Authors: Kalit Samir , Tudor Kalit Milna , Dolenčić Špehar Iva , Salajpal Krešimir , Samaržija Dubravka , Anušić Jasna , Rako Ante
Published: March 2021

The aim of this work was to evaluate the influence of cheese milk standardization on chemical composition, fat and protein recovery, yield and sensory properties of Croatian soft Protected Geographical Indication (PGI) Lički škripavac cheese. Standardization of milk to the casein/fat ratio of 0.7 was carried out by adding skimmed milk powder (SMP) to cheese milk and by skimming part of the milk fat. Results showed that losses of fat by whey were significantly (p < 0.05) lower after Lički škripavac cheese produced from standardized milk by skimming part of the milk fat. Standardization of cheese milk by addition of SMP caused higher losses of protein (p < 0.05) and total solids (p < 0.0001) by whey. Both methods of cheese milk standardization caused a significant (p < 0.01) decrease in milk fat and fat in dry matter content in cheese. In contrast, standardization of cheese milk caused a significant (p < 0.01) increase in protein content in cheese milk. Moisture in non-fat substance (MNFS) significantly (p < 0.05) decreased. Optimization of the casein/fat ratio did not cause a significant increase in fat recovery, but protein recovery significantly increased (p < 0.01). Addition of SMP to cheese milk significantly (p < 0.01) increased actual and adjusted cheese yield. The addition of SMP led to a noticeably higher (p = 0.10) sensory score of Lički škripavac cheese.
Estimation of Effect of Radiation Dose Reduction for Internal Exposure by Food Regulations under the Current Criteria for Radionuclides in Foodstuff in Japan Using Monitoring Results
Authors: Osanai Minoru , Hirano Daisuke , Mitsuhashi Shiori , Kudo Kohsei , Hosokawa Shota , Tsushima Megumi , Iwaoka Kazuki , Yamaguchi Ichiro , Tsujiguchi Takakiyo , Hosoda Masahiro , Hosokawa Yoichiro , Saito Yoko
Published: March 2021

This study examined the effect of food regulations under the current criteria (e.g., 100 Bq/kg for general foods) established approximately a year after the Fukushima Dai-ichi Nuclear Power Plant (FDNPP) accident. Foods are monitored to ensure that foods exceeding the standard limit are not distributed; ~300,000 examinations per year have been performed especially since FY2014. This study comprehensively estimated the internal exposure dose resulting from the ingestion of foods containing radioactive cesium using the accumulated monitoring results. Committed effective dose was conservatively calculated as the product of the radioactive concentration randomly sampled from test results, food intake, and dose coefficient. The median, 95th, and 99th percentile of the dose were 0.0479, 0.207, and 10.6 mSv/y, respectively, in the estimation with all test results (without regulation), and 0.0430, 0.0790, and 0.233 mSv/y, respectively, in the estimation with results within the standard limits (with regulation) in FY2012. In FY2016, the dose with and without regulation were similar, except for high percentile, and those doses were significantly smaller than 1 mSv/y, which was adopted as the basis for the current criteria. The food regulation measures implemented in Japan after the FDNPP accident have been beneficial, and food safety against radionuclides has been ensured.
Comparative Assessment of Tubular Ceramic, Spiral Wound, and Hollow Fiber Membrane Microfiltration Module Systems for Milk Protein Fractionation
Authors: Schopf Roland , Schmidt Florian , Linner Johanna , Kulozik Ulrich
Published: March 2021

The fractionation efficiency of hollow fiber membranes (HFM) for milk protein fractionation was compared to ceramic tubular membranes (CTM) and spiral wound membranes (SWM). HFM combine the features of high membrane packing density of SWM and the more defined flow conditions and better control of membrane fouling in the open flow channel cross-sections of CTM. The aim was to comparatively analyze the effect of variations in local pressure and flow conditions while using single industrially sized standard modules with similar dimensions and module footprints (module diameter and length). The comparative assessment with varied transmembrane pressure was first applied for a constant feed volume flow rate of 20 m3 h−1 and, secondly, with the same axial pressure drop along the modules of 1.3 bar m−1, similar to commonly applied crossflow velocity and wall shear stress conditions at the industrial level. Flux, transmission factor of proteins (whey proteins and serum caseins), and specific protein mass flow per area membrane and per volume of module installed were determined as the evaluation criteria. The casein-to-whey protein ratios were calculated as a measure for protein fractionation effect. Results obtained show that HFM, which so far are under-represented as standard module types in industrial dairy applications, appear to be a competitive alternative to SWM and CTM for milk protein fractionation.
Assessing the Determinants of the Wish to Die among the Elderly Population in Ghana
Authors: Simmons Sally Sonia , Maiolo Valeria , Ahinkorah Bright Opoku , Hagan John Elvis , Seidu Abdul-Aziz , Schack Thomas
Published: March 2021

Background: A wish to die is common in elderly people. Concerns about death wishes among the elderly have risen in Ghana, where the ageing transition is comparable to other low-and middle-income countries. However, nationally representative research on death wishes in the elderly in the country is not readily available. Our study aimed to assess the determinants of the wish to die among the elderly in Ghana. Methods: We analysed data from the World Health Organisation Global Ageing and Adult Health Survey, Wave 1 (2007–2008) for Ghana. Data on the wish to die, socio-demographic profiles, health factors and substance abuse were retrieved from 2147 respondents aged 65 and above. Ages of respondents were categorised as 65–74 years; 75–84 years; 85+ to reflect the main stages of ageing. Logistic regression models were fitted to assess the association between these factors and the wish to die. Results: Age, sex, place of residence, education, body mass index, hypertension, stroke, alcohol consumption, tobacco use, income, diabetes, visual impairment, hopelessness and depression had statistically significant associations with a wish to die. Older age cohorts (75–84 and 85+) were more likely to have the wish to die (AOR = 1.05, CI = 1.02–1.16; AOR = 1.48, CI = 1.22–1.94), compared to younger age cohorts (65–74 years). Persons who felt hopeless had higher odds (AOR = 2.15, CI = 2.11–2.20) of experiencing the wish to die as compared to those who were hopeful. Conclusions: In view of the relationship between socio-demographic (i.e., age, sex, education and employment), hopelessness, anthropometric (body mass index), other health factors and the wish to die among the elderly in Ghana, specific biopsychosocial health promotion programmes, including timely identification of persons at risk, for appropriate intervention (e.g., psychotherapy, interpersonal support, alcohol-tobacco cessation therapy, clinical help) to promote their wish for a longer life is needed.
Deterioration, Compensation and Motor Control Processes in Healthy Aging, Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Poirier Gabriel , Ohayon Alice , Juranville Adrien , Mourey France , Gaveau Jeremie
Published: March 2021

Aging is associated with modifications of several brain structures and functions. These modifications then manifest as modified behaviors. It has been proposed that some brain function modifications may compensate for some other deteriorated ones, thus maintaining behavioral performance. Through the concept of compensation versus deterioration, this article reviews the literature on motor function in healthy and pathological aging. We first highlight mechanistic studies that used paradigms, allowing us to identify precise compensation mechanisms in healthy aging. Subsequently, we review studies investigating motor function in two often-associated neurological conditions, i.e., mild cognitive impairment and Alzheimer’s disease. We point out the need to expand the knowledge gained from descriptive studies with studies targeting specific motor control processes. Teasing apart deteriorated versus compensating processes represents precious knowledge that could significantly improve the prevention and rehabilitation of age-related loss of mobility.
The Role of Feminist Health Humanities Scholarship and Black Women’s Artistry in Re-Shaping the Origin Narrative of Modern, U.S. Gynecology
Authors: Dudley Rachel
Published: March 2021

Between 1845–1849, twelve enslaved women in Montgomery, Alabama lived through prolonged, gynecologic experimentation at the hands of Dr. James Marion Sims. What happened, in his 16-bed backyard hospital, often begins the origin narrative of modern U.S. gynecology and how it developed into a discrete and international, Western, scientific field of medicine. Sims autobiography references three of these women, by their first names only: Anarcha, Lucy and Betsey. The research questions here are: what more can be known about these women’s lives, their possible social networks and their cultural legacies? Further, what changes if the origin narrative of modern, U.S. gynecology begins with feminist health humanities scholarship and in the pages of black women’s artistry? I discuss original research findings, involving the following primary source: an 1841 property deed, mentioning the first names of 7 other enslaved people owned by Sims. I, then, examine cotemporary U.S. feminist scholarly writing and artistic cultural representations, centering the lives of the women as important historical figures. Last, I conceptualize the notion of poetic ancestral witnessing within the work of the following three, twenty-first century, African American, poets: Bettina Judd, Dominique Christina and Kwoya Fagin Maples. These women published poetry collections on this history, between 2014 and 2018.
Part I: Relationship among Training Load Management, Salivary Immunoglobulin A, and Upper Respiratory Tract Infection in Team Sport: A Systematic Review
Authors: Rico-González Markel , Clemente Filipe Manuel , Oliveira Rafael , Bustamante-Hernández Naia , Pino-Ortega José
Published: March 2021

Immunoglobulin A (IgA), which is the first line of defense against upper respiratory tract viruses, has been related with training load management. This article aimed to systematically identify and summarize (1) the studies that have found a relationship between training load and salivary IgA in team sports, and (2) the studies that have highlighted a relationship between IgA and upper respiratory tract infection (URTI) in team sports. A systematic review of relevant articles was carried out using two electronic databases (PubMed and WoK) until 3 October 2020. From a total of 174 studies initially found, 24 were included in the qualitative synthesis. This systematic review confirmed that lower values of IgA occurred after greater training load (intensity/volume) and congested periods. In this scenario, a low level of IgA was correlated with higher URTI, which makes training load management mandatory to healthcare avoiding immunosuppression. Therefore, physical fitness and conditioning coaches should carefully manage training load progression, avoiding high-intensity sessions in two consecutive days. In addition, they should not program high-intensity training sessions during at least the two days following competition.
Visual Positioning in Indoor Environments Using RGB-D Images and Improved Vector of Local Aggregated Descriptors
Authors: Zhang Longyu , Xia Hao , Liu Qingjun , Wei Chunyang , Fu Dong , Qiao Yanyou
Published: March 2021

Positioning information has become one of the most important information for processing and displaying on smart mobile devices. In this paper, we propose a visual positioning method using RGB-D image on smart mobile devices. Firstly, the pose of each image in the training set is calculated through feature extraction and description, image registration, and pose map optimization. Then, in the image retrieval stage, the training set and the query set are clustered to generate the vector of local aggregated descriptors (VLAD) description vector. In order to overcome the problem that the description vector loses the image color information and improve the retrieval accuracy under different lighting conditions, the opponent color information and depth information are added to the description vector for retrieval. Finally, using the point cloud corresponding to the retrieval result image and its pose, the pose of the retrieved image is calculated by perspective-n-point (PnP) method. The results of indoor scene positioning under different illumination conditions show that the proposed method not only improves the positioning accuracy compared with the original VLAD and ORB-SLAM2, but also has high computational efficiency.
Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease
Authors: Hetzel Miriam , Ackermann Mania , Lachmann Nico
Published: March 2021

Macrophages act as immune scavengers and are important cell types in the homeostasis of various tissues. Given the multiple roles of macrophages, these cells can also be found as tissue resident macrophages tightly integrated into a variety of tissues in which they fulfill crucial and organ-specific functions. The lung harbors at least two macrophage populations: interstitial and alveolar macrophages, which occupy different niches and functions. In this review, we provide the latest insights into the multiple roles of alveolar macrophages while unraveling the distinct factors which can influence the ontogeny and function of these cells. Furthermore, we will highlight pulmonary diseases, which are associated with dysfunctional macrophages, concentrating on congenital diseases as well as pulmonary infections and impairment of immunological pathways. Moreover, we will provide an overview about different treatment approaches targeting macrophage dysfunction. Improved knowledge of the role of macrophages in the onset of pulmonary diseases may provide the basis for new pharmacological and/or cell-based immunotherapies and will extend our understanding to other macrophage-related disorders.
Transient Receptor Potential Ankyrin 1 (TRPA1)—An Inflammation-Induced Factor in Human HaCaT Keratinocytes
Authors: Luostarinen Samu , Hämäläinen Mari , Moilanen Eeva
Published: March 2021

Transient receptor potential ankyrin 1 (TRPA1) is an ion channel mainly studied in sensory neurons where it mediates itch, pain and neurogenic inflammation. Recently, some nonneuronal cells have also been shown to express TRPA1 to support inflammatory responses. To address the role of TRPA1 in skin inflammation, we aimed to investigate TRPA1 expression in keratinocytes. HaCaT cells (a model of human keratinocytes) and skin biopses from wild-type and TRPA1 deficient mice were used in the studies. TRPA1 expression in nonstimulated keratinocytes was very low but significantly inducible by the proinflammatory cytokine tumor necrosis factor (TNF) in an nuclear factor kappa B (NF-κB), and mitogen-activated protein (MAP) kinase (p38 and c-Jun N-terminal kinase, JNK)-dependent manner. Interestingly, drugs widely used to treat skin inflammation, the calcineurin inhibitors tacrolimus and cyclosporine and the glucocorticoid dexamethasone, significantly decreased TRPA1 expression. Furthermore, pharmacological inhibition and genetic deletion of TRPA1 reduced the synthesis of TNF-induced monocyte chemoattractant protein 1 (MCP-1) in keratinocytes and mouse skin biopsies. In conclusion, these findings point to an inflammatory role for TRPA1 in keratinocytes and present TRPA1 as a potential drug target in inflammatory skin diseases.
Plant Growth Promotion Function of Bacillus sp. Strains Isolated from Salt-Pan Rhizosphere and Their Biocontrol Potential against Macrophomina phaseolina
Authors: Castaldi Stefany , Petrillo Claudia , Donadio Giuliana , Piaz Fabrizio Dal , Cimmino Alessio , Masi Marco , Evidente Antonio , Isticato Rachele
Published: March 2021

In recent decades, intensive crop management has involved excessive use of pesticides or fertilizers, compromising environmental integrity and public health. Accordingly, there has been worldwide pressure to find an eco-friendly and safe strategy to ensure agricultural productivity. Among alternative approaches, Plant Growth-Promoting (PGP) rhizobacteria are receiving increasing attention as suitable biocontrol agents against agricultural pests. In the present study, 22 spore-forming bacteria were selected among a salt-pan rhizobacteria collection for their PGP traits and their antagonistic activity against the plant pathogen fungus Macrophomina phaseolina. Based on the higher antifungal activity, strain RHFS10, identified as Bacillus vallismortis, was further examined and cell-free supernatant assays, column purification, and tandem mass spectrometry were employed to purify and preliminarily identify the antifungal metabolites. Interestingly, the minimum inhibitory concentration assessed for the fractions active against M. phaseolina was 10 times lower and more stable than the one estimated for the commercial fungicide pentachloronitrobenzene. These results suggest the use of B. vallismortis strain RHFS10 as a potential plant growth-promoting rhizobacteria as an alternative to chemical pesticides to efficiently control the phytopathogenic fungus M. phaseolina.
How Can Malnutrition Affect Autophagy in Chronic Heart Failure? Focus and Perspectives
Authors: Corsetti Giovanni , Pasini Evasio , Romano Claudia , Chen-Scarabelli Carol , Scarabelli Tiziano M. , Flati Vincenzo , Saravolatz Louis , Dioguardi Francesco S.
Published: March 2021

Chronic heart failure (CHF) is a disease with important clinical and socio-economic ramifications. Malnutrition and severe alteration of the protein components of the body (protein disarrangements), common conditions in CHF patients, are independent correlates of heart dysfunction, disease progression, and mortality. Autophagy, a prominent occurrence in the heart of patients with advanced CHF, is a self-digestive process that prolongs myocardial cell lifespan by the removal of cytosolic components, such as aging organelles and proteins, and recycles the constituent elements for new protein synthesis. However, in specific conditions, excessive activation of autophagy can lead to the destruction of molecules and organelles essential to cell survival, ultimately leading to organ failure and patient death. In this review, we aim to describe the experimental and clinical evidence supporting a pathophysiological role of nutrition and autophagy in the progression of CHF. The understanding of the mechanisms underlying the interplay between nutrition and autophagy may have important clinical implications by providing molecular targets for innovative therapeutic strategies in CHF patients.
Is Chelation Therapy a Potential Treatment for Parkinson’s Disease?
Authors: Ward Roberta J. , Dexter David T. , Martin-Bastida Antonio , Crichton Robert R.
Published: March 2021

Iron loading in some brain regions occurs in Parkinson’s Disease (PD), and it has been considered that its removal by iron chelators could be an appropriate therapeutic approach. Since neuroinflammation with microgliosis is also a common feature of PD, it is possible that iron is sequestered within cells as a result of the “anaemia of chronic disease” and remains unavailable to the chelator. In this review, the extent of neuroinflammation in PD is discussed together with the role played by glia cells, specifically microglia and astrocytes, in controlling iron metabolism during inflammation, together with the results of MRI studies. The current use of chelators in clinical medicine is presented together with a discussion of two clinical trials of PD patients where an iron chelator was administered and showed encouraging results. It is proposed that the use of anti-inflammatory drugs combined with an iron chelator might be a better approach to increase chelator efficacy.
The Rare Word Issue in Natural Language Generation: A Character-Based Solution
Authors: Bonetta Giovanni , Roberti Marco , Cancelliere Rossella , Gallinari Patrick
Published: March 2021

In this paper, we analyze the problem of generating fluent English utterances from tabular data, focusing on the development of a sequence-to-sequence neural model which shows two major features: the ability to read and generate character-wise, and the ability to switch between generating and copying characters from the input: an essential feature when inputs contain rare words like proper names, telephone numbers, or foreign words. Working with characters instead of words is a challenge that can bring problems such as increasing the difficulty of the training phase and a bigger error probability during inference. Nevertheless, our work shows that these issues can be solved and efforts are repaid by the creation of a fully end-to-end system, whose inputs and outputs are not constrained to be part of a predefined vocabulary, like in word-based models. Furthermore, our copying technique is integrated with an innovative shift mechanism, which enhances the ability to produce outputs directly from inputs. We assess performance on the E2E dataset, the benchmark used for the E2E NLG challenge, and on a modified version of it, created to highlight the rare word copying capabilities of our model. The results demonstrate clear improvements over the baseline and promising performance compared to recent techniques in the literature.
Selection Criteria for Building Materials and Components in Line with the Circular Economy Principles in the Built Environment—A Review of Current Trends
Authors: Rahla Kamel Mohamed , Mateus Ricardo , Bragança Luís
Published: March 2021

A growing concern is given to the environmental impacts caused by the construction industry. Waste generation, resource consumption, and greenhouse gas emissions are the main drawbacks of the rapid urbanization that the world is witnessing. As a response to these pressing issues, policymakers and academia are exploring the concept of Circular Economy (CE) to manage resources better and achieve resource efficiency while eliminating waste. One of the strategies to implement CE in the built environment is to select the appropriate building materials and components from the early stages to carry out the concept’s principles along the value chain and create a closed-loop system. Therefore, this study aims at identifying selection criteria for building elements according to CE principles through a review of the latest research. Results have shown that little has been concretely achieved in terms of a paradigm shift to CE since the main focus of the literature is still the use of recycled products and the recyclability of building materials and components at their end-of-life. Although the present study is solely focused on the technical aspect of building materials and components, it outlines current adopted criteria to bring about a circular built environment and highlights the need for a more innovative approach to attain higher circularity levels.
Global Habitat Suitability of Spodoptera frugiperda (JE Smith) (Lepidoptera, Noctuidae): Key Parasitoids Considered for Its Biological Control
Authors: Tepa-Yotto Ghislain T. , Tonnang Henri E. Z. , Goergen Georg , Subramanian Sevgan , Kimathi Emily , Abdel-Rahman Elfatih M. , Flø Daniel , Thunes Karl H. , Fiaboe Komi K. M. , Niassy Saliou , Bruce Anani , Mohamed Samira A. , Tamò Manuele , Ekesi Sunday , Sæthre May-Guri
Published: March 2021

The present study is the first modeling effort at a global scale to predict habitat suitability of fall armyworm (FAW), Spodoptera frugiperda and its key parasitoids, namely Chelonus insularis, Cotesia marginiventris,Eiphosoma laphygmae,Telenomus remus and Trichogramma pretiosum, to be considered for biological control. An adjusted procedure of a machine-learning algorithm, the maximum entropy (Maxent), was applied for the modeling experiments. Model predictions showed particularly high establishment potential of the five hymenopteran parasitoids in areas that are heavily affected by FAW (like the coastal belt of West Africa from Côte d’Ivoire (Ivory Coast) to Nigeria, the Congo basin to Eastern Africa, Eastern, Southern and Southeastern Asia and some portions of Eastern Australia) and those of potential invasion risks (western & southern Europe). These habitats can be priority sites for scaling FAW biocontrol efforts. In the context of global warming and the event of accidental FAW introduction, warmer parts of Europe are at high risk. The effect of winter on the survival and life cycle of the pest in Europe and other temperate regions of the world are discussed in this paper. Overall, the models provide pioneering information to guide decision making for biological-based medium and long-term management of FAW across the globe.
dsRNA-Mediated Pest Management of Tuta absoluta Is Compatible with Its Biological Control Agent Nesidiocoris tenuis
Authors: Sarmah Nomi , Kaldis Athanasios , Taning Clauvis Nji Tizi , Perdikis Dionysios , Smagghe Guy , Voloudakis Andreas
Published: March 2021

RNAi-mediated insect pest management has recently shown promising results against the most serious pest of tomato, the tomato leafminer, Tuta absoluta. This study aimed to investigate whether dsRNA (dsTa-αCOP) designed to target the T. absoluta-αCOP gene could cause adverse effects to its biocontrol agent, the mirid predator, Nesidiocoris tenuis. Oral exposure of N. tenuis to dsRNA (dsNt-αCOP) designed to target N. tenuis-αCOP resulted in a 61%, 67% and 55% reduction in its transcript level in comparison to the sucrose, dsGFP and dsTa-αCOP treatments, respectively. In addition, significantly higher mortality of 57% was recorded in dsNt-αCOP-treated N. tenuis when compared to the sucrose (7%), dsGFP (10%) and dsTa-αCOP (10%) treatments. Moreover, the predation rate of ~33–39 Ephestia kuehniella eggs per N. tenuis adult dramatically reduced to almost half in the surviving dsNt-αCOP-treated N. tenuis. This worst-case exposure scenario confirmed for the first time that the RNAi machinery is functional in this species and that the risk of exposure through the oral route is possible. In contrast, dsTa-αCOP did not cause any sub-lethal effects to N. tenuis upon oral exposure. Oral exposure of T. absoluta to dsTa-αCOP resulted in 50% mortality. In the context of a biosafety risk assessment of RNAi-mediated insect management, investigating the effects on non-target organisms is essential in order to include this method as part of an integrated pest management strategy. Based on our laboratory assays, RNAi-mediated control is compatible with the biological control of T. absoluta by its natural enemy N. tenuis, adding the RNAi approach in the armoire of integrated pest management of T. absoluta.
Rapid Assessment of Cerambycid Beetle Biodiversity in a Tropical Rainforest in Yunnan Province, China, Using a Multicomponent Pheromone Lure
Authors: Wickham Jacob D. , Harrison Rhett D. , Lu Wen , Chen Yi , Hanks Lawrence M. , Millar Jocelyn G.
Published: March 2021

The Cerambycidae comprise a large and ecologically important family of wood-boring beetles. The purpose of this study was to examine the effectiveness of a generic lure as a potential monitoring tool. Working in a subtropical forest in southwest China, we set traps baited with generic lures at ground level (1 m) and canopy height (~18 m) across 22 randomly located forest plots (12 regenerating forest, 10 mature forest). Three stations were established per plot and each plot was trapped for 7 days in May–June 2013. In total, 4541 beetles of 71 species were caught, including 26 species with 10 or more individuals. We used Hierarchical Modeling of Species Communities (HMSC) to analyze the data and produced informative models for 18 species, showing that trap height, slope, elevation, and leaf-area index were important determinants of cerambycid distribution. Our results demonstrate the potential for using generic lures to detect and monitor cerambycid populations, both for regulatory purposes and for the study of cerambycid beetle ecology. Further research should focus on refining lure blends, and on repeated sampling to determine temporal and spatial dynamics of cerambycid communities.
Characteristics and Treatment of Atrial Fibrillation with Respect to the Presence or Absence of Heart Failure. Insights from the Multicenter Polish Atrial Fibrillation (POL-AF) Registry
Authors: Gawałko Monika , Budnik Monika , Gorczyca Iwona , Jelonek Olga , Uziębło-Życzkowska Beata , Maciorowska Małgorzata , Wójcik Maciej , Błaszczyk Robert , Tokarek Tomasz , Rajtar-Salwa Renata , Bil Jacek , Wojewódzki Michał , Szpotowicz Anna , Krzciuk Małgorzata , Bednarski Janusz , Bakuła-Ostalska Elwira , Tomaszuk-Kazberuk Anna , Szyszkowska Anna , Wełnicki Marcin , Mamcarz Artur , Kapłon-Cieślicka Agnieszka
Published: March 2021

Background: We aimed to assess characteristics and treatment of AF patients with and without heart failure (HF). Methods: The prospective, observational Polish Atrial Fibrillation (POL-AF) Registry included consecutive patients with AF hospitalized in 10 Polish cardiology centers in 2019–2020. Results: Among 3999 AF patients, 2822 (71%) had HF (AF/HF group). Half of AF/HF patients had preserved ejection fraction (HFpEF). Compared to patients without HF (AF/non–HF), AF/HF patients were older, more often male, more often had permanent AF, and had more comorbidities. Of AF/HF patients, 98% had class I indications to oral anticoagulation (OAC). Still, 16% of patients were not treated with OAC at hospital admission, and 9%—at discharge (regardless of the presence of HF and its subtypes). Of patients not receiving OAC upon admission, 61% were prescribed OAC (most often apixaban) at discharge. AF/non–HF patients more often converted from AF at admission to sinus rhythm at discharge compared to AF/HF patients (55% vs. 30%), despite cardioversion performed as often in both groups. Class I antiarrhythmics were more often prescribed in AF/non–HF than in AF/HF group (13% vs. 8%), but still as many as 15% of HFpEF patients received them. Conclusions: Over 70% of hospitalized AF patients have coexisting HF. A significant number of AF patients does not receive the recommended OAC.
Exercise Evaluation and Prescription
Authors: Foster Carl , Cortis Cristina , Fusco Andrea
Published: March 2021

Ever since the farm boy, Milo of Crotone, lifted a growing bullock every day, to become the strongest man in the world, and six-time champion of the ancient Olympic Games, we have known about the principle of progression of exercise training [...]
Condition Monitoring of Manufacturing Processes under Low Sampling Rate
Authors: Bernard Gabriel , Achiche Sofiane , Girard Sébastien , Mayer René
Published: March 2021

Manufacturing processes can be monitored for anomalies and failures just like machines, in condition monitoring and prognostic and health management. This research takes inspiration from condition monitoring and prognostic and health management techniques to develop a method for part production process monitoring. The contribution brought by this paper is an automated technique for process monitoring that works with low sampling rates of 1/3Hz, a limitation that comes from using data provided by an industrial partner and acquired from industrial manufacturing processes. The technique uses kernel density estimation functions on machine tools spindle load historical time signals for distribution estimation. It then uses this estimation to monitor the manufacturing processes for anomalies in real time. A modified version was tested by our industrial partner on a titanium part manufacturing line.
A Coupled Hydrodynamic-Equilibrium Type Beach Profile Evolution Model
Authors: Birrien Florent , Baldock Tom
Published: March 2021

An equilibrium beach profile model is developed and coupled with a parametric hydrodynamic model to provide feedback between the evolving morphology and the hydrodynamics. The model is compared to laboratory beach profiles evolving toward equilibrium conditions under constant forcing. The equilibrium model follows the classical approach but uses the bulk sediment transport as the governing model parameter. This approach is coupled with empirically derived and normalised sediment transport functions and a parametric surf zone wave transformation model. The dissipation predicted by the surf zone model controls the cross-shore position of the maxima in the sediment transport functions and hence the cross-shore evolution of the beach profile. Realistic beach profile shapes are generated for both erosive (barred) and accretive (bermed) beach profiles, and predictions of bar and berm position are satisfactory. With more complex normalised sediment transport functions, the model can be applied to conditions with a cyclical wave climate. However, the model concept is better associated with erosive wave conditions and further work is required to improve the link between the modelled dissipation and local transport for accretive conditions.
Fractional-Order Elastoplastic Modeling of Sands Considering Cyclic Mobility
Authors: Wu Leiye , Cheng Wei , Zhu Zhehao
Published: March 2021

Seabed soil may experience a reduction in strength or even liquefaction when subjected to cyclic loadings exerted by offshore structures and environmental loadings such as ocean waves and earthquakes. A reasonable and robust constitutive soil model is indispensable for accurate assessment of such structure–seabed interactions in marine environments. In this paper, a new constitutive model is proposed by enriching subloading surface theory with a fractional-order plastic flow rule and multiple hardening rules. A detailed validation of both stress- and strain-controlled undrained cyclic test results of medium-dense Karlsruhe fine sand is provided to demonstrate the robustness of the present constitutive model to capture the non-associativity and cyclic mobility of sandy soils. The new fractional cyclic model is then implemented into a finite element code based on a two-phase field theory via a user subroutine, and a numerical case study on the response of seabed soils around a submarine pipeline under cyclic wave loadings is presented to highlight the practical applications of this model in structure–seabed interactions.