bluuebunny/crossref_metadata_2025 huggingface dataset:
A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease
Authors: Hao Jingcan , Wang Wenyu , Wen Yan , Xiao Xiao , He Awen , Guo Xiong , Yang Tielin , Liu Xiaogang , Shen Hui , Chen Xiangding , Tian Qing , Deng Hong-Wen , Zhang Feng
Published: August 2016

Kashin-Beck disease (KBD) is a chronic osteoarthropathy, which manifests as joint deformities and growth retardation. Only a few genetic studies of growth retardation associated with the KBD have been carried out by now. In this study, we conducted a two-stage bivariate genome-wide association study (BGWAS) of the KBD using joint deformities and body height as study phenotypes, totally involving 2,417 study subjects. Articular cartilage specimens from 8 subjects were collected for immunohistochemistry. In the BGWAS, ADAM12 gene achieved the most significant association (rs1278300 p-value = 9.25 × 10−9) with the KBD. Replication study observed significant association signal at rs1278300 (p-value = 0.007) and rs1710287 (p-value = 0.002) of ADAM12 after Bonferroni correction. Immunohistochemistry revealed significantly decreased expression level of ADAM12 protein in the KBD articular cartilage (average positive chondrocyte rate = 47.59 ± 7.79%) compared to healthy articular cartilage (average positive chondrocyte rate = 64.73 ± 5.05%). Our results suggest that ADAM12 gene is a novel susceptibility gene underlying both joint destruction and growth retardation of the KBD.
Asymmetric Collagen/chitosan Membrane Containing Minocycline-loaded Chitosan Nanoparticles for Guided Bone Regeneration
Authors: Ma Shiqing , Adayi Aidina , Liu Zihao , Li Meng , Wu Mingyao , Xiao Linghao , Sun Yingchun , Cai Qing , Yang Xiaoping , Zhang Xu , Gao Ping
Published: August 2016

Infections caused by pathogens colonization at wound sites in the process of bone healing are considered as one of the major reasons for the failure of guided bone regeneration (GBR). The objective of this study was to prepare a novel asymmetric collagen/chitosan GBR membrane containing minocycline-loaded chitosan nanoparticles. The morphologies of the membranes and nanoparticles were observed by SEM and TEM, respectively. The characterization and biocompatibility of the membranes was evaluated. The effect of the membrane on bone regeneration was assessed using the critical-size at cranial defect model. TEM images showed the spherical morphology of the nanoparticles. The results of SEM indicated that the asymmetric membrane contained a dense collagen layer and a loose chitosan layer. An in vitro experiment showed that the membrane can inhibit bacterial growth and promote osteoblasts and fibroblasts growth. The membrane showed the ability to promote angiogenesis and enhance bone regeneration in vivo. An asymmetric collagen/chitosan GBR membrane can be fabricated by loading minocycline encapsulated chitosan nanoparticles, and shows satisfactory biocompatibility and barrier function, which enhances bone regeneration. Therefore, this antibacterial GBR membrane is a promising therapeutic approach to prevent infection and guide bone regeneration.
Filtrating colorectal cancer associated genes by integrated analyses of global DNA methylation and hydroxymethylation in cancer and normal tissue
Authors: Li Ming , Gao Fei , Xia Yudong , Tang Yi , Zhao Wei , Jin Congcong , Luo Huijuan , Wang Junwen , Li Qingshu , Wang Yalan
Published: August 2016

Recently, 5-hydroxymethylcytosine patterning across the tumor genome was considered as a hallmark of cancer development and progression. However, locus-specific difference of hydroxymethylation between colorectal cancer and normal tissue is unknown. In this study, we performed a newly developed method, HMST-seq, to profile 726 aberrant methylated loci and 689 aberrant hydroxymethylated loci synchronously in genome wide of colorectal cancers, majority of which presented higher methylation or lower hydroxymethylationin than in normal group. Besides, abnormal hydroxymethylated modification was more frequently occur at proximal regions close to TSSs and TSSs regions than abnormal methylation. Subsequently, we screened four genes (ALOX15, GHRHR, TFPI2 and TKTL1) with aberrant methylation and aberrant hydroxymethylation at some genome position by functional enrichment analysis as candidate genes associated with colorectal cancer. Our results may allow us to select differentially epigenetically modified target genes implicated in colorectal cancer tumorigenesis.
IL-21/IL-21R signaling suppresses intestinal inflammation induced by DSS through regulation of Th responses in lamina propria in mice
Authors: Wang Yuanyuan , Jiang Xuefeng , Zhu Junfeng , Dan Yue  , Zhang Xiaoqing , Wang Xiao , You Yong , Wang Biao , Xu Ying , Lu Changlong , Sun Xun , Yoshikai Yasunobu
Published: August 2016

Serum level of IL-21 is increased in patients with inflammatory bowel diseases (IBD), suggesting that IL-21/IL-21 receptor (IL-21R) signaling may be involved in the pathogenesis of IBD. However, the role of IL-21/IL-21 receptor signaling plays in the pathogenesis of IBD is not very clear. In this study, using IL-21R.KO mice, we tested the role of IL-21/IL-21R signaling in the regulation of T helper cell responses during intestinal inflammation. Here we found that IL-21R.KO mice were more susceptible to DSS-induced colitis as compared with C57BL/6 mice. The spontaneous inflammatory cytokines released by macrophages in LP of colon were significantly increased and Th2, Th17 and Treg responses were down-regulated markedly. However, Th1 responses were significantly up-regulated in IL-21R.KO mice. Meanwhile, the population of CD8+CD44+IFN-γ+ T cells was markedly elevated in LP of inflammatory intestine of IL-21RKO mice. In vivo, after disease onset, DSS-induced intestinal inflammation was ameliorated in C57BL/6 mice treated with rIL-21. Our results demonstrate that IL-21/IL-21R signaling contributes to protection against DSS-induced acute colitis through suppression of Th1 and activation of Th2, Th17 and Treg responses in mice. Therefore, therapeutic manipulation of IL-21/IL-21R activity may allow improved immunotherapy for IBD and other inflammatory diseases associated with Th cell responses.
A rock-salt-type Li-based oxide, Li3Ni2RuO6, exhibiting a chaotic ferrimagnetism with cluster spin-glass dynamics and thermally frozen charge carriers
Authors: Upadhyay Sanjay Kumar , Iyer Kartik K. , Rayaprol S. , Paulose P. L. , Sampathkumaran E. V.
Published: August 2016

The area of research to discover new Li containing materials and to understand their physical properties has been of constant interest due to applications potential for rechargeable batteries. Here, we present the results of magnetic investigations on a Li compound, Li3Ni2RuO6, which was believed to be a ferrimagnet below 80 K. While our neutron diffraction (ND) and isothermal magnetization (M) data support ferrimagnetism, more detailed magnetic studies establish that this ferrimagnetic phase exhibits some features similar to spin-glasses. In addition, we find another broad magnetic anomaly around 40–55 K in magnetic susceptibility (χ), attributable to cluster spin-glass phenomenon. Gradual dominance of cluster spin-glass dynamics with a decrease of temperature (T) and the apparent spread in freezing temperature suggest that the ferrimagnetism of this compound is a chaotic one. The absence of a unique freezing temperature for a crystalline material is interesting. In addition, pyroelectric current (Ipyro) data reveals a feature in the range 40–50 K, attributable to thermally stimulated depolarization current. We hope this finding motivates future work to explore whether there is any intriguing correlation of such a feature with cluster spin-glass dynamics. We attribute these magnetic and electric dipole anomalies to the crystallographic disorder, intrinsic to this compound.
Visual detection of Maize chlorotic mottle virus by asymmetric polymerase chain reaction with unmodified gold nanoparticles as the colorimetric probe
Authors: Wang Lin , Liu Zhanmin , Xia Xueying , Huang Junyi
Published: August 2016

Maize chlorotic mottle virus causes corn lethal necrosis disease and can transmit via infected maize seeds.
Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides to yield 1-amino-1H-indenes
Authors: Singh RahulKumar Rajmani , Pawar Samir Kundlik , Huang Min-Jie , Liu Rai-Shung
Published: August 2016

Gold-catalyzed [3+2]-annulations of α-aryl diazonitriles with ynamides and allenamides yielding 1-amino-1H-indenes in two distinct pathways have been reported.
2D materials for renewable energy storage devices: Outlook and challenges
Authors: Sahoo Ramkrishna , Pal Anjali , Pal Tarasankar
Published: August 2016

We review cost-effective, clean and durable alternative energy devices based on 2D materials.
Understanding memory effects in Li-ion batteries: evidence of a kinetic origin in TiO2 upon hydrogen annealing
Authors: Ventosa E. , Löffler T. , La Mantia F. , Schuhmann W.
Published: August 2016

Kinetic aspects, specifically Li-ion mobility, are found to determine the magnitude of the memory effect in TiO2 by studying samples with different levels of oxygen vacancies.
Hydrogen evolution from water using Mo–oxide clusters in the gas phase: DFT modeling of a complete catalytic cycle using a Mo2O4−/Mo2O5− cluster couple
Authors: Ray Manisha , Saha Arjun , Raghavachari Krishnan
Published: August 2016

Hydrogen evolution from water using sacrificial reagents and Mo–oxide cluster anions has been explored. The internal energy preservation within the clusters plays a key role in the catalytic cycle.
Rapid acquisition of wideline MAS solid-state NMR spectra with fast MAS, proton detection, and dipolar HMQC pulse sequences
Authors: Rossini Aaron J. , Hanrahan Michael P. , Thuo Martin
Published: August 2016

Fast MAS and proton detection are applied to rapidly acquire wideline solid-state NMR spectra of spin-1/2 and half-integer quadrupolar nuclei.
A joint experimental and theoretical determination of the structure of discharge products in Na–SO2 batteries
Authors: Han Young-Kyu , Jeong Goojin , Lee Keon-Joon , Yim Taeeun , Kim Young-Jun
Published: August 2016

This work is the first to elucidate the governing mechanism of molten-salt batteries by combining experimental and theoretical NMR measurements.
New molecular scale insights into the α-transition of Nafion® thin films from variable temperature ATR-FTIR spectroscopy
Authors: Ozhukil Kollath V. , Karan K.
Published: August 2016

IR spectroscopy based direct evidence of long range order–disorder in the Nafion backbone correlated with the α-transition temperature.
Variational first hyperpolarizabilities of 2,3-naphtho-15-crown-5 ether derivatives with cation-complexing: a potential and selective cation detector
Authors: Yu Hai-Ling , Wang Wen-Yong , Hong Bo , Zong Ying , Si Yan-Ling , Hu Zhong-Qiang
Published: August 2016

When the crown ether and its cation derivatives display obvious contrasts in NLO properties, the NLO-based detection of cations is achieved.
The impact of environment and resonance effects on the site of protonation of aminobenzoic acid derivatives
Authors: Seo Jongcheol , Warnke Stephan , Gewinner Sandy , Schöllkopf Wieland , Bowers Michael T. , Pagel Kevin , von Helden Gert
Published: August 2016

Ion mobility- andm/z-selected infrared spectroscopy unambiguously determines the site of protonation ofp-,m-, ando-aminobenzoic acid derivatives.
Evidence of spin-temperature in dynamic nuclear polarization: an exact computation of the EPR spectrum
Authors: Caracciolo Filippo , Filibian Marta , Carretta Pietro , Rosso Alberto , De Luca Andrea
Published: August 2016

We show the validity of the spin-temperature approach for typical radical concentration used in dissolution DNP protocols.
Isomerisation versus carbonylative pathways in the hydroxy-carbonylation, methoxy-carbonylation, and amino-carbonylation of N-tosyl-3-pyrroline
Authors: Fuentes José A. , Durrani Jamie T. , Leckie Stuart M. , Crawford L. Ellis , Bühl Michael , Clarke Matthew L.
Published: August 2016

DFT calculations show that the competition between carbonylation and isomerisation pathways using Pd/phosphine catalysts can be steered toward the desired carbonylation using less bulky ligands. Thus, the normally less effective phanephos family forms carbonylation products with good ee.
Revisiting oxo-centered carbonyl-triruthenium clusters: investigating CO photorelease and some spectroscopic and electrochemical correlations
Authors: Moreira Mariete B. , Da Silva Camila F. N. , Pesci Rafaela B. P. , Deflon Victor M. , Nikolaou Sofia
Published: August 2016

This work presents the correlations of the spectroscopic and electrochemical properties of triruthenium carbonyl μ-oxo complexes with the σ-donor or π-acceptor ability of ancillary ligands.
Controlled formation of ordered coordination polymeric networks using silsesquioxane building blocks
Authors: Banerjee Subhabrata , Kataoka Sho , Takahashi Toshikazu , Kamimura Yoshihiro , Suzuki Kunio , Sato Kazuhiko , Endo Akira
Published: August 2016

In this report, we synthesized ordered coordination polymers using polyhedral oligomeric silsesquioxanes (POSS) as a building block.
Simultaneous introduction of various palladium active sites into MOF via one-pot synthesis: Pd@[Cu3−xPdx(BTC)2]n
Authors: Zhang Wenhua , Chen Zhihao , Al-Naji Majd , Guo Penghu , Cwik Stefan , Halbherr Olesia , Wang Yuemin , Muhler Martin , Wilde Nicole , Gläser Roger , Fischer Roland A.
Published: August 2016

Simultaneous introduction of various palladium active sites into MOF to form Pd@[Cu3−xPdx(BTC)2]n has been achieved and show good catalytic activity.
A fluorescence study on the complexation of Sm(iii), Eu(iii) and Tb(iii) with tetraalkyldiglycolamides (TRDGA) in aqueous solution, in solid state, and in solvent extraction
Authors: Kou Fei , Yang Suliang , Qian Hongjuan , Zhang Lihua , Beavers Christine M. , Teat Simon J. , Tian Guoxin
Published: August 2016

Trivalent lanthanide ions form 1 : 1, 1 : 2, and 1 : 3 complexes with tridentate ligand TMDGA in 1 M H/NaNO3and form 1 : 3 extracted complexes with DMDODGA during solvent extraction.
Lipid droplet size and emulsification on postprandial glycemia, insulinemia and lipidemia
Authors: Tan Kevin Wei Jie , Sun Li Juan , Goh Kelvin Kim Tha , Henry Christiani Jeyakumar
Published: August 2016

Emulsification and alteration of the lipid droplet size have acute effects on glucose, insulin, triglyceride and fatty acid responses.
An engineered solvent system for sugar production from lignocellulosic biomass using biomass derived γ-valerolactone
Authors: Motagamwala Ali Hussain , Won Wangyun , Maravelias Christos T. , Dumesic James A.
Published: August 2016

We demonstrate the design of a solvent system for efficient production and enhanced separation of carbohydrates from lignocellulosic biomass.
Evidence for charge transfer from hydrogen molecular ions to copper atoms in a neon–hydrogen analytical glow discharge
Authors: Mushtaq Sohail , Steers Edward B. M. , Hoffmann Volker , Weiss Zdeněk , Pickering Juliet C.
Published: August 2016

We show initial evidence that analyte atoms can be ionized by asymmetric charge transfer (ACT) process involving molecular ions, (M2+-ACT) in analytical glow discharges.
Dual transcript and protein quantification in a massive single cell array
Authors: Park Seung-min , Lee Jae Young , Hong Soongweon , Lee Sang Hun , Dimov Ivan K. , Lee Hojae , Suh Susie , Pan Qiong , Li Keyu , Wu Anna M. , Mumenthaler Shannon M. , Mallick Parag , Lee Luke P.
Published: August 2016

Microwell-based cytometry for simultaneous gene and protein measurements from single cells.
SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors
Authors: Phummarin Narisa , Boshoff Helena I. , Tsang Patricia S. , Dalton James , Wiles Siouxsie , Barry 3rd Clifton E. , Copp Brent R.
Published: August 2016

New antimycobacterial 2-(quinoline-4-yloxy)acetamides were prepared, and using gene deletion and resistant mutants, we conclude that the compound class inhibits the mycobacterial cytochrome bc1 complex.
Investigation of thermochromic photoluminescent, dielectric and crystal structural properties for an inorganic–organic hybrid solid of [1-hexyl-3-methylimidazolium][PbBr3]
Authors: Wan Kun-Ming , Tong Yuan-Bo , Li-Li Li-Li , Zou Yang , Duan Hai-Bao , Liu Jian-Lan , Ren Xiao-Ming
Published: August 2016

An imidazolium-based bromoplumbate hybrid solid shows fascinating luminescence thermochromism, appealing dielectric anomaly and relaxation.
Facile preparation of three-dimensional Ni(OH)2/Ni foam anode with low cost and its application in a direct urea fuel cell
Authors: Ye Ke , Zhang Hongyu , Zhao Lutian , Huang Xiaomei , Cheng Kui , Wang Guiling , Cao Dianxue
Published: August 2016

The nano-sheet Ni(OH)2/Ni foam electrode exhibits superior catalytic activity and stability towards urea electro-oxidation and shows a good fuel cell performance.
A step-economical multicomponent synthesis of 3D-shaped aza-diketopiperazines and their drug-like chemical space analysis
Authors: Regenass Pierre , Riché Stéphanie , Péron Florent , Rognan Didier , Hibert Marcel , Girard Nicolas , Bonnet Dominique
Published: August 2016

A rapid and atom economical multicomponent synthesis of complex aza-diketopiperazines (aza-DKPs) driven by Rh(i)-catalyzed hydroformylation of alkenylsemicarbazides is described.
Total synthesis of mangiferin, homomangiferin, and neomangiferin
Authors: Wei Xiong , Liang Danlin , Wang Qing , Meng Xiangbao , Li Zhongjun
Published: August 2016

Efficient synthesis of naturalC-glycosyl xanthone mangiferin, homomangiferin and neomangiferin based on their biosynthetic pathway.
Total synthesis of cananginone C and structural revision of debilisone A
Authors: Kuilya Tapan Kumar , Goswami Rajib Kumar
Published: August 2016

A strategy for stereoselective total synthesis of bioactive γ-lactone based natural products cananginone C and debilisone A has been developed.
Synthesis and biomedical applications of fluorescent nanogels
Authors: Liu Wei , Zhang Wensi , Yu Xiaoqing , Zhang Guanghua , Su Zhiqiang
Published: August 2016

Fluorescent nanogel is an innovative biomedical material with hydroscopicity, degradability, and responsiveness.
Well-defined poly(vinylidene fluoride) (PVDF) based-dendrimers synthesized by click chemistry: enhanced crystallinity of PVDF and increased hydrophobicity of PVDF films
Authors: Folgado Enrique , Guerre Marc , Bijani Christian , Ladmiral Vincent , Caminade Anne-Marie , Ameduri Bruno , Ouali Armelle
Published: August 2016

This study reports the preparation of a novel fluorinated dendrimer bearing PVDF branches by click chemistry and its characterization by several analytical methods.
In situ formed graphene/ZnO nanostructured composites for low temperature hydrogen sulfide removal from natural gas
Authors: Lonkar Sunil P. , Pillai Vishnu , Abdala Ahmed , Mittal Vikas
Published: August 2016

Nanostructured composites of graphene and highly dispersed sub-20 nm sized ZnO nanoparticles (TRGZ) were prepared via a novel method combining freeze-drying and thermal annealing.
Constant rate thermal analysis of a dehydrogenation reaction
Authors: Perejón Antonio , Pérez-Maqueda Luis A. , Sánchez-Jiménez Pedro E. , Criado José M. , Murafa Nataliya , Subrt Jan
Published: August 2016

The kinetic analysis of constant rate thermal analysis (CRTA) curves obtained for MgH2 dehydrogenation under high vacuum reveals that the reaction obeys first-order kinetics.
Theoretical view on a linear end-on manganese–dioxygen complex bearing a calix[4]arene ligand
Authors: Huang Xiang-Cui , Wang Hui-Fang , Lang Jian-Ping
Published: August 2016

The Mn–O–O angle of mononuclear manganese(iii)-superoxo complexes supported by zwitterionic calix[4]arene ligands can be modulated via solvent polarity perturbations and/or ligand size adjustment as indicated by DFT calculations.
Noncovalent interactions between the second coordination sphere and the active site of [NiFeSe] hydrogenase
Authors: Vedha Swaminathan Angeline , Velmurugan Gunasekaran , Venuvanalingam Ponnambalam
Published: August 2016

QM/MM studies on seven truncated models of the oxidized as-isolated state of the [NiFeSe] Hases reveal the influence of the residues in the second coordination sphere on the active site.
Microwave-assisted synthesis of highly crystalline, multifunctional iron oxide nanocomposites for imaging applications
Authors: Williams Marc J. , Sánchez Enrique , Aluri Esther Rani , Douglas Fraser J. , MacLaren Donald A. , Collins Oonagh M. , Cussen Edmund J. , Budge James D. , Sanders Lara C. , Michaelis Martin , Smales C. Mark , Cinatl Jindrich , Lorrio Silvia , Krueger Dirk , de Rosales Rafael T. M. , Corr Serena A.
Published: August 2016

We report a single-step, microwave-assisted approach for the preparation of multifunctional magnetic nanocomposites. We demonstrate the link between synthetic methodology and the functionality of the nanocomposites as biomedical imaging agents.
Synthesis of high quality CuO nanoflakes and CuO–Au nanohybrids for superior visible light photocatalytic behavior
Authors: Zhang Xinyu , Yang Yawei , Que Wenxiu , Du Yaping
Published: August 2016

High-quality CuO nanoflakes and CuO–Au nanohybrids are synthesized by a facile wet chemistry strategy. Compared with pure CuO nanoflakes, CuO–Au nanohybrids exhibit superior visible light-driven photocatalytic performance and have a higher photocurrent density (46 mA cm−2).
A flexible lead-free piezoelectric nanogenerator based on vertically aligned BaTiO3 nanotube arrays on a Ti-mesh substrate
Authors: Tsege Ermias Libnedengel , Kim Gyu Han , Annapureddy Venkateswarlu , Kim Beomkeun , Kim Hyung-Kook , Hwang Yoon-Hwae
Published: August 2016

A novel, flexible lead-free piezoelectric nanogenerator was developed using a uniform BaTiO3 film; synthesized by in situ conversion of titanium oxide nanotubes in a low temperature hydrothermal process.
Synthesis of novel flower-like PtCo–Bi2MoO6 photocatalysts with enhanced visible light photocatalytic performance
Authors: Lu Yan , Li Xiaoxuan , Han Changcun , Ge Lei , Fang Siman , Qiu Ping
Published: August 2016

A novel PtCo/Bi2MoO6 composite photocatalyst was successfully synthesized by loading PtCo alloy nanoparticles via a simple polyol reduction method.
Atmospheric oxidation mechanism of OH-initiated reactions of diethyl ether – the fate of the 1-ethoxy ethoxy radical
Authors: Sandhiya L. , Ponnusamy S. , Senthilkumar K.
Published: August 2016

The 1-ethoxy ethoxy radical resulting from the secondary peroxy chemistry in the oxidation of diethyl ether (DEE) by hydroxyl radical leads to the formation of ethyl formate in major quantities and ethyl acetate in minor quantities.
Silicon nanowires and nanotrees: elaboration and optimization of new 3D architectures for high performance on-chip supercapacitors
Authors: Gaboriau D. , Aradilla D. , Brachet M. , Le Bideau J. , Brousse T. , Bidan G. , Gentile P. , Sadki S.
Published: August 2016

Micro-supercapacitors are increasingly foreseen as future energy storage or power buffer solutions for small scale integration on-chip. This study develops optimized silicon nanotrees as an innovative electrode material.
Enhanced photocatalytic performance and morphology evolvement of PbWO4 dendritic nanostructures through Eu3+ doping
Authors: Yue Dan , Chen Dong , Lu Wei , Wang Mengnan , Zhang Xiaoli , Wang Zhenling , Qian Guodong
Published: August 2016

Eu3+ ion doping can enhance the photocatalytic activity of PbWO4 dendritic nanostructures and affect the morphology as well.
Thermal relaxation in combination with fiberglass confined interpenetrating networks: a key calcination process for as-desired free standing metal oxide nanofibrous membranes
Authors: Subjalearndee Nakarin , Intasanta Varol
Published: August 2016

Using Pd/Pt-decorated solar light active ZnWO4/mixed-phased TiO2nanofibers as a model subject, we investigate the prerequisites for the construction of mechanically stable metal oxide nanofibrous membranes.
A dynamic chitosan-based self-healing hydrogel with tunable morphology and its application as an isolating agent
Authors: Maity Santu , Datta Arpita , Lahiri Susanta , Ganguly Jhuma
Published: August 2016

A biopolymer chitosan based hydrogel with good transparency and rapid self-healing activity has been synthesized and utilized to get high purity separation of 152Eu (T1/2 = 13.33 a) and 137Cs (T1/2 = 30.17 a) employing SLX technique.
Construction of a ternary hybrid of CdS nanoparticles loaded on mesoporous-TiO2/RGO for the enhancement of photocatalytic activity
Authors: Tian Hongwei , Wan Chenxing , Zheng Weitao , Hu Xiaoying , Qiao Liang , Wang Xiaoyi
Published: August 2016

An as-prepared ternary meso-TiO2/RGO/CdS catalyst to photodegrade MO exhibited enhanced photocatalytic activity under the irradiation of simulated solar light.
Magnetic field-induced fabrication of Fe3O4/graphene nanocomposites for enhanced electrode performance in lithium-ion batteries
Authors: Wang Huan , Xie Jingyi , Follette Marissa , Back Tyson C. , Amama Placidus B.
Published: August 2016

We report a novel magnetic field-induced approach for the fabrication of nanoporous and wrinkled Fe3O4/reduced graphene oxide (RGO) anode materials for lithium ion batteries (LIBs).
A sensitive fluorescence sensor for glutathione detection based on MnO2nanosheets–copper nanoclusters composites
Authors: Wang Hai-Bo , Chen Ying , Li Yang , Liu Yan-Ming
Published: August 2016

A sensitive fluorescence sensor has been developed for glutathione detection based on MnO2nanosheets–Cu NCs composites.
A low-cost, highly-conductive polyvinyl alcohol flexible film with Ag-microsheets and AgNWs as fillers
Authors: Mao Yongyun , Guo Junmei , Hu Changyi , Yang Hongwei , Yang Yuwen , Chen Song
Published: August 2016

Low-cost, high-conductivity flexible conductive films were fabricated using Ag-microsheets, Ag-nanowires (AgNWs) and polyvinyl alcohol (PVA) as conducting agents. The flexible conductive film shows good conductivity under stretching.
Adsorption of radioactive iodine on surfactant-modified sodium niobate
Authors: Mu Wanjun , Yu Qianhong , Li Xingliang , Wei Hongyua , Jian Yuan
Published: August 2016

To capture radioactive iodine from wastewater, nanofibers and cubes of Ag2O anchored to sodium niobate composites were prepared as absorbents.
Push–pull type alkoxy-wrapped N-annulated perylenes for dye-sensitized solar cells
Authors: Qi Qingbiao , Zhang Jing , Das Soumyajit , Zeng Wangdong , Luo Jie , Zhang Jie , Wang Peng , Wu Jishan
Published: August 2016

Three push–pull type, alkoxy-wrapped N-annulated perylene based sensitizers were synthesized and power conversion efficiency up to 8.38% was achieved.
Gallium-catalyzed reductive lactonization of γ-keto acids with a hydrosilane
Authors: Sakai Norio , Horikawa Shuhei , Ogiwara Yohei
Published: August 2016

Gallium chloride efficiently catalyzes cyclization of γ-keto carboxylic acids in the presence of PhSiH3 to produce the corresponding γ-lactone derivatives.
Novel cholesteric liquid crystalline elastomers containing dimer type nematic and chiral liquid crystalline side-chains
Authors: Jiang Ying , Cong Yuehua , Zhang Baoyan
Published: August 2016

A new set of cholesteric side chain liquid crystalline elastomers (ChLCEs) E1–E7 were graft copolymerized by hydrosilylation reaction with poly(methylhydrogeno)siloxane, nematic monomer (M1), chiral monomer (M2), and crosslinking agent (CL).
Hydrophobic modification of polypropylene/starch blend foams through tailoring cell diameter for oil-spill cleanup
Authors: Xu Mingzhi , Bian Junjia , Han Changyu , Dong Lisong
Published: August 2016

PP/starch blend foams with good hydrophobicity and oil recovery efficiency were prepared by tailoring cell diameter without involving any chemicals.
Correction: Synergic therapy of melanoma using GNRs-MUA-PEI/siIDO2-FA through targeted gene silencing and plasmonic photothermia
Authors: Zhang Yujuan , Song Na , Fu Jiamin , Liu Yanling , Zhan Xuelin , Peng Shanshan , Yang Zhi , Zhu Xianfang , Chen Yiguo , Wang Zhigang , Yu Yanrong , Shi Qiaofa , Fu Yingyuan , Yuan Keng , Zhou Nanjin , Ichim Thomas E. , Min Weiping
Published: August 2016

Correction for ‘Synergic therapy of melanoma using GNRs-MUA-PEI/siIDO2-FA through targeted gene silencing and plasmonic photothermia’ by Yujuan Zhang et al., RSC Adv., 2016, 6, 77577–77589.
Dendritic polarizing agents for DNP SENS
Authors: Liao Wei-Chih , Ong Ta-Chung , Gajan David , Bernada Florian , Sauvée Claire , Yulikov Maxim , Pucino Margherita , Schowner Roman , Schwarzwälder Martin , Buchmeiser Michael R. , Jeschke Gunnar , Tordo Paul , Ouari Olivier , Lesage Anne , Emsley Lyndon , Copéret Christophe
Published: August 2016

Dendrimer-shielded polarizing agents for the application of DNP SENS to reactive surfaces.
Interfacial behaviours between lithium ion conductors and electrode materials in various battery systems
Authors: Wu Bingbin , Wang Shanyu , Evans IV Willie J. , Deng Daniel Z. , Yang Jihui , Xiao Jie
Published: August 2016

The interfacial impedances existing on electrode/solid electrolyte interfaces dictate the transport of Li-ions during the electrochemical processes.
A novel pseudocapacitance mechanism of elm seed-like mesoporous MoO3−x nanosheets as electrodes for supercapacitors
Authors: Lu Qian-Long , Zhao Shi-Xi , Chen Chang-Ke , Wang Xia , Deng Yu-Feng , Nan Ce-Wen
Published: August 2016

Elm seed-like mesoporous MoO3−x nanosheets were synthesised, and possess both redox and intercalation faradic pseudocapacitance mechanisms.
Odd–even effects of an asymmetric dimer on the double-twist structure in an amorphous blue phase
Authors: Hirose Tetsu , Yoshizawa Atsushi
Published: August 2016

Some chiral mixtures doped with a small amount of an even-membered asymmetric dimer were found to exhibit a phase sequence of I–N*H–BPIII–N*L.
Submodule configuration of HVDC‐DC autotransformer considering DC fault
Authors: Suo Zhiwen , Li Gengyin , Li Rui , Xu Lie , Wang Weisheng , Chi Yongning , Sun Wei
Published: August 2016

This paper studies the submodule configuration of modular multilevel converter (MMC) based non‐isolated HVDC‐DC autotransformer (HVDC‐AT) with DC fault blocking capability, including two‐terminal and multi‐terminal topologies. The operation principle of the HVDC‐AT is described. Considering the arm current differences, the total number of required semiconductors for the HVDC‐AT is derived and is compared with the MMC based isolated front‐to‐front DC transformer. A full operation process for the multi‐terminal HVDC‐AT considering DC fault is then presented, including normal operation, fault isolation and continuous operation of healthy converters after fault. The submodule configuration and fault recovery of the multi‐terminal HVDC‐AT are validated by simulations using PSCAD/EMTDC.
Determination of the best Weibull methods for wind power assessment in the southern region of Turkey
Authors: kaplan Yusuf Alper
Published: August 2016

In this study, wind energy potential in the South of Turkey was investigated statistically by using the Turkish State Meteorological Service's hourly wind speed data between 2009 and 2013. The wind data used in this study were gathered from the Meteorology Station in Hatay and Osmaniye. In this study, different numerical methods were analysed and their performances were compared for effectiveness in determining the shape ‘k’ and scale ‘c’ parameters of the Weibull distribution function for two different regions. Six different methods: namely, graphical method, empirical method, maximum likelihood method, energy trend method, energy pattern method and moment method were used to estimate the Weibull parameters. The following statistical indicators were used for comparing the efficiency of all the methods used: the root mean square error, analysis of variance (R2) and mean percentage error. Wind power densities were also calculated for all numerical methods used in this study. The power density is the key issue for the suitable use of wind energy. The calculated power densities for all methods used were compared with wind power density derived from measured wind data for two regions.
Adaptive fault identification of bearing using empirical mode decomposition–principal component analysis‐based average kurtosis technique
Authors: Mohanty Satish , Gupta Karunesh Kumar , Raju Kota Solomon
Published: August 2016

The kinematics of the bearing is erratic and random in nature and requires timely attention to avoid any catastrophic failure. In this study, the authors have proposed and analysed the amplitude and frequency modulated signals emanating from the bearing using four steps, i.e. standardisation, empirical mode decomposition, principal component analysis (PCA), envelope and cepstral envelope techniques. First, the standardised frequency modulated signals are decomposed into stationary non‐linear modes called intrinsic mode functions (IMFs). In this approach, PCA is applied on the decomposed IMFs to produce uncorrelated signals. The uncorrelated signals whose value is above the average kurtosis are recombined to form a modified signal. The modified signal incurred from the approach is followed by spectrum, envelope, cepstrum, and cepstral envelope techniques to identify the features. It is observed this proposed combined approach effectively and adaptively identifies the inner/ball faults, shaft rotating frequency and corresponding harmonics in ease with least utilisation of IMFs.
The Strong Family Program: an innovative model to engage Aboriginal and Torres Strait Islander youth and Elders with reproductive and sexual health community education
Authors: Duley P. , Botfield J. R. , Ritter T. , Wicks J. , Brassil A.
Published: August 2016

Issue addressed

Aboriginal youth in Australia often experience high rates of intimate partner violence (family violence) and poorer reproductive and sexual health than their non‐Aboriginal counterparts. To address some of the disparities, the Strong Family Program was developed to deliver reproductive and sexual health education to Aboriginal communities in New South Wales.

Methods

Development of the program was based on an extensive consultation process with Aboriginal communities. It was implemented in three communities, with two groups from each hosting Aboriginal youth and Elders in a yarning circle within the culturally respectful frameworks of ‘men and boys’’ and ‘women and girls’’ business. An evaluation was conducted to measure reproductive and sexual health knowledge and attitude changes upon program completion, using pre‐ and post‐program surveys and yarning (focus group discussions).

Results

Program participants comprised 48 females and 28 males. Overall, mean knowledge and attitude scores improved upon completion of the program (from 77% to 82% and from 4.15 to 4.32 out of 5, respectively). Among participants aged 20 years and under (the youngest participant was 13 years), there was an increase in knowledge (P = 0.034); among participants aged over 20 years (the oldest participant was 78 years), there was an increase in positive attitudes (P = 0.001). Participants perceived the information provided to be useful and relevant, with many reporting improved knowledge and attitudes around rights and respectful relationships.

Conclusions

Reproductive and sexual health education in Aboriginal communities should be based on community consultations and carried out within a culturally appropriate framework to promote greater success. Continued implementation of the Strong Family Program will promote increased understanding of respectful relationships and improved health outcomes for Aboriginal young people.

So what?

The Strong Family Program was based on an extensive consultative process that ensured leadership and involvement from Aboriginal communities, with program content and delivery based on Aboriginal pedagogy and reflecting Aboriginal cultural values. Reproductive and sexual health promotion in Aboriginal communities should be based on community consultations and carried out within a culturally appropriate framework to promote greatest success.
Spatial and temporal variations of soil function in a Mediterranean serpentine ecosystem
Authors: Monokrousos Nikolaos , Charalampidis George , Kapagianni Pantelitsa , Argyropoulou Maria D. , Papatheodorou Efimia M.
Published: August 2016

We investigated the variations in space and time of soil functionality in a Mediterranean serpentine soil for heavy metal and nutrient concentrations, microbial biomass and soil enzymatic activities (urease, dehydrogenase and alkaline phosphatase) in the rhizospheres of different plant species and in bare soil, during the humid and dry seasons of the year. Nutrients and heavy metals were also estimated in leaves of shrubs inhabiting the study area. Four species of serpentine-tolerant shrubs were present: the evergreen-sclerophyllous Juniperus oxycedrus and Buxus sempervirens and the phryganic Cistus creticus and Thymus sibthorpii. The most significant differentiation of the soil environment was between bare and rhizosphere soil, and was mainly driven by the availability of potassium. Spatial variations related to plant identity were clear but less important than temporal variations. There was no relationship between soil and foliar concentrations of nutrients and heavy metals. Higher foliar concentrations were recorded in the phryganic species. Finally, there was no enzyme inhibition due to the heavy metal load of the serpentine soil. Enzymatic activities were lower for bare soil samples, while their temporal variations probably followed the temporal variations of temperature and humidity imposed by the Mediterranean climate.
The main agricultural insect and disease pests of China and implications for the use of remote sensing for their management.
Authors: Cock M. J. W. , Tang Rui Tang Rui , Liu Zhi Liu Zhi , Wan HuanHuan Wan HuanHuan , McGillivray L. A. , Thomas S. E. , Cameron K. H. , Zhang Feng Zhang Feng
Published: August 2016

This review selects the major agricultural insect and disease pests of agriculture in China, and discusses the implications for developing the use of remote sensing to improve their management. The most important crops were selected as those, which contribute more than 5% nationally in terms of total agricultural land occupied, total weight of agricultural produce or total value of agricultural produce: i.e. rice, wheat, maize, potato, sugarcane and brassica crops (for which Chinese cabbage was used as an exemplar). Our approach to selecting the most important pests on these crops was to compile lists for each crop of the pests that are primary pests on that crop, and either have at least 20 papers published regarding their occurrence on that crop in China, or occur in at least 17 of the 34 provincial-level administrative districts. Based on these factors, we identified 3-6 major pests for each crop. These selections were then discussed with national IPM experts to assess their appropriateness, and minor adjustments made. This gave us a list of 29 major insect and disease pests for China. We also identified those pests of our selected major crops in neighbouring countries that presented a quarantine risk, or might be expected to threaten China as climate changes, i.e., (i) those pests present in central Asia (and further west), which could spread to China without climate change and (ii) pests which are more tropical in distribution, but could spread north with climate warming. Tables were compiled on symptoms, thresholds for action and options for pest management responses. These are discussed in terms of the scope for remote sensing of these pests in China and how the information generated or forecast would be used to improve pest management in the context of the existing agricultural extension service. Recommendations are made for future work.
Residual stress analysis of machined lead-free and lead-containing brasses
Authors: Tam P. L. , Schultheiss F. , Ståhl J. -E. , Nyborg L.
Published: August 2016

Legislations demand low lead content in drinking water and low lead leaching from the water supply facilities. Lead-free brass (LFB) can fit in. The benefits of such alloy are acknowledged in both functional and environmental points of view. The relatively high strength of LFB means that the process condition and residual stress generation can be different as compared to the conventional brass. In this study, residual stress generation for a LFB (CuZn21Si3P) and a lead-containing brass (CuZn39Pb3) in a face-turning experiment is studied. Besides stress analysis, structural characterisation is also conducted. Stress generation in the feed and cutting directions of two brasses is depicted. Machined topography is measured to evaluate the surface integrity in connection with the machining conditions.

This paper is part of a Themed Issue on Brass Alloys.
Eph-mediated tyrosine phosphorylation of citron kinase controls abscission
Authors: Jungas Thomas , Perchey Renaud T. , Fawal Mohamad , Callot Caroline , Froment Carine , Burlet-Schiltz Odile , Besson Arnaud , Davy Alice
Published: August 2016

Cytokinesis is the last step of cell division, culminating in the physical separation of daughter cells at the end of mitosis. Cytokinesis is a tightly regulated process that until recently was mostly viewed as a cell-autonomous event. Here, we investigated the role of Ephrin/Eph signaling, a well-known local cell-to-cell communication pathway, in cell division. We show that activation of Eph signaling in vitro leads to multinucleation and polyploidy, and we demonstrate that this is caused by alteration of the ultimate step of cytokinesis, abscission. Control of abscission requires Eph kinase activity, and Src and citron kinase (CitK) are downstream effectors in the Eph-induced signal transduction cascade. CitK is phosphorylated on tyrosines in neural progenitors in vivo, and Src kinase directly phosphorylates CitK. We have identified the specific tyrosine residues of CitK that are phosphorylated and show that tyrosine phosphorylation of CitK impairs cytokinesis. Finally, we show that, similar to CitK, Ephrin/Eph signaling controls neuronal ploidy in the developing neocortex. Our study indicates that CitK integrates intracellular and extracellular signals provided by the local environment to coordinate completion of cytokinesis.
Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion
Authors: Dolat Lee , Spiliotis Elias T.
Published: August 2016

Macropinocytosis, the internalization of extracellular fluid and material by plasma membrane ruffles, is critical for antigen presentation, cell metabolism, and signaling. Macropinosomes mature through homotypic and heterotypic fusion with endosomes and ultimately merge with lysosomes. The molecular underpinnings of this clathrin-independent endocytic pathway are largely unknown. Here, we show that the filamentous septin GTPases associate preferentially with maturing macropinosomes in a phosphatidylinositol 3,5-bisphosphate–dependent manner and localize to their contact/fusion sites with macropinosomes/endosomes. Septin knockdown results in large clusters of docked macropinosomes, which persist longer and exhibit fewer fusion events. Septin depletion and overexpression down-regulates and enhances, respectively, the delivery of fluid-phase cargo to lysosomes, without affecting Rab5 and Rab7 recruitment to macropinosomes/endosomes. In vitro reconstitution assays show that fusion of macropinosomes/endosomes is abrogated by septin immunodepletion and function-blocking antibodies and is induced by recombinant septins in the absence of cytosol and polymerized actin. Thus, septins regulate fluid-phase cargo traffic to lysosomes by promoting macropinosome maturation and fusion with endosomes/lysosomes.
Mitotic exit: Determining the PP2A dephosphorylation program
Authors: Pereira Gislene , Schiebel Elmar
Published: August 2016

In mitotic exit, proteins that were highly phosphorylated are sequentially targeted by the phosphatase PP2A-B55, but what underlies substrate selection is unclear. In this issue, Cundell et al. (2016. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201606033) identify the determinants of PP2A-B55’s dephosphorylation program, thereby influencing spindle disassembly, nuclear envelope reformation, and cytokinesis.
Balance between transmitted HLA preadapted and nonassociated polymorphisms is a major determinant of HIV-1 disease progression
Authors: Mónaco Daniela C. , Dilernia Dario A. , Fiore-Gartland Andrew , Yu Tianwei , Prince Jessica L. , Dennis Kristine K. , Qin Kai , Schaefer Malinda , Claiborne Daniel T. , Kilembe William , Tang Jianming , Price Matt A. , Farmer Paul , Gilmour Jill , Bansal Anju , Allen Susan , Goepfert Paul , Hunter Eric
Published: August 2016

HIV-1 adapts to a new host through mutations that facilitate immune escape. Here, we evaluate the impact on viral control and disease progression of transmitted polymorphisms that were either preadapted to or nonassociated with the new host’s HLA. In a cohort of 169 Zambian heterosexual transmission pairs, we found that almost one-third of possible HLA-linked target sites in the transmitted virus Gag protein are already adapted, and that this transmitted preadaptation significantly reduced early immune recognition of epitopes. Transmitted preadapted and nonassociated polymorphisms showed opposing effects on set-point VL and the balance between the two was significantly associated with higher set-point VLs in a multivariable model including other risk factors. Transmitted preadaptation was also significantly associated with faster CD4 decline (<350 cells/µl) and this association was stronger after accounting for nonassociated polymorphisms, which were linked with slower CD4 decline. Overall, the relative ratio of the two classes of polymorphisms was found to be the major determinant of CD4 decline in a multivariable model including other risk factors. This study reveals that, even before an immune response is mounted in the new host, the balance of these opposing factors can significantly influence the outcome of HIV-1 infection.
Cardiac Manifestations of Systemic Diseases and Pregnancy
Authors: Blauwet Lori A. , Mankad Rekha , Phillips Sabrina D. , Klarich Kyle W.
Published: August 2016

Cardiovascular manifestations of hyperthyroidism include increased heart rate, stroke volume, and cardiac output. Peripheral vascular resistance is decreased, and thus pulse pressure is widened. As a result, myocardial oxygen consumption increases, which may precipitate angina. Other symptoms include palpitations, presyncope or syncope, and exertional dyspnea. Arrhythmias may occur. Common symptoms include weight loss, weakness (especially in the elderly), and tachycardia or palpitations.
Cardiovascular Physical Examination
Authors: Klarich Kyle W. , Blauwet Lori A. , Phillips Sabrina D.
Published: August 2016

Jugular venous pressure reflects right atrial pressure and the relationship between right atrial filling and emptying into the right ventricle. Changes in wave amplitude may indicate structural disease and rhythm changes. Normal jugular venous pressure is 6 to 8 cm H2O. It is best evaluated with the patient supine at an angle of at least 45°. The right atrium lies 5 cm below the sternal angle, and thus the estimated jugular venous pressure equals the height of the jugular venous pressure above the sternal angle + 5 cm.
Hypertension
Authors: Collins C. Scott , Wittich Christopher M.
Published: August 2016

Hypertension is the most common condition seen in primary care. Hypertension can lead to myocardial infarction, stroke, renal failure, and death if not adequately treated. A normal blood pressure is defined as less than 120/80 mm Hg. Prehypertension is defined as a blood pressure of 120-139/80-89 mm Hg. Stage 1 hypertension is a blood pressure of 140-159/90-99 mm Hg, and stage 2 hypertension is a blood pressure of 160 or more/100 or more mm Hg.