bluuebunny/crossref_metadata_2025 huggingface dataset:
Aggressive sinonasal angiomyxoma management with endoscopic medial maxillectomy approach: a rare case report
Authors: Thamrin Mohammad Husni , Sutikno Budi
Published: January 2025

Link of Video Abstract: https://youtu.be/SNbUkDVumjI
 
Background: Aggressive angiomyxoma is a benign tumour of mesenchymal origin, and its incidence is very rare. The treatment of choice for aggressive sinonasal angiomyxoma is surgical extirpation based on the location of the tumour. The surgical procedure can be performed endoscopically or externally. This study aims to report the management of an aggressive sinonasal angiomyxoma rare case with an endoscopic approach.
Case presentation: A 20-year-old female came with the chief complaint of a blocked right nose for the past six months. Patients often had varying amounts of intermittent epistaxis from the right nose, which could stop by itself but in a longer time. Three studies met the inclusion criteria and stated that aggressive sinonasal angiomyxoma is rare. Extirpation surgery was performed with an endoscopic medial maxillectomy approach. Histopathology showed a benign mesenchymal cell tumour consistent with angiomyxoma.
Conclusion: The sinonasal tumour with an early preoperative diagnosis of an antrochoanal polyp and a postoperative diagnosis of an aggressive sinonasal angiomyxoma underwent extirpation surgery with an endoscopic medial maxillectomy approach results in no recurrences after two years.
Effectivity and safety profile of oxalate decarboxylase in hyperoxaluria patient: A meta-analysis and systematic review
Authors: Rodjani Arry , Putra Christian Nurtanto , Raharja Putu Angga Risky , Widia Fina , Situmorang Gerhard Reinaldi , Rahardjo Harrina Erlianti , Wahyudi Irfan
Published: January 2025

Link of Video Abstract: https://youtu.be/BNXqnQcXK8U
 
Introduction: The high incidence of urinary stones leads to many related medical issues and substantial financial burdens. In addition to treatment interventions, executing preventive measures is crucial in reducing the likelihood of kidney stone recurrence. Oxalate decarboxylase is now being developed as a preventive measure for treating hyperoxaluria, a risk factor for stone formation. This study aims to evaluate the efficacy and safety of oxalate decarboxylase in treating hyperoxaluria.
Methods: A comprehensive review of the existing literature was performed by conducting a systematic search across various databases, including Cochrane Library, Google Scholar, PubMed, and Embase. The mean difference (MD) of 24-hour urinary oxalate excretion from baseline to treatment was assessed in each study. Cochrane Collaboration’s Review Manager 5.4.1 software was used for statistical analysis, and RoB 2 tools were used for bias risk assessment.
Result: Five studies that satisfied the specified criteria were included in the analysis, 3  of which were analyzed for meta-analysis data, while the other for systematic review. Meta-analysis showed that oxalate decarboxylase had a statistically significant efficacy compared to placebo in reducing oxaluria with MD of 9,72 mg/day (95% CI 7,43 to 12,10). Regarding safety, there is not much difference in the number of complications between oxalate decarboxylase and placebo, with only one study reporting a serious adverse event (SAE) of sacral radiculopathy in the intervention group.
Conclusion: Oxalate decarboxylase is a potential and promising alternative treatment for reducing urinary oxalate levels in hyperoxaluria patients. Therefore, it can be regarded as a viable choice in pharmacological treatment for preventing the occurrence of oxalate stones in patients in the future.
The difference in fecundity capacity, hatching ability, larva development, and esterase pattern of Aedes aegypti with different breeding places
Authors: Sudarmaja I Made , Yasa I Wayan Putu Sutirta , Widjana Dewa Putu , Swastika I Kadek , Sutisna Putu
Published: January 2025

Introduction: Mosquito-transmitted diseases are a significant global health issue, especially in tropical regions. This study aimed to evaluate the difference in fecundity capacity, hatching ability, larva development, and esterase pattern of Aedes aegypti with different breeding places
Methods: From January to December 2014, a randomized post-test-only control group study was conducted at Udayana and Gadjah Mada Universities. Aedes aegypti mosquitoes were bred in clear, sand-based, soil-based, soapy, and detergent water. Differences in fecundity, hatching ability, and larval development were analyzed using ANOVA and LSD tests, with esterase variations examined using chi-square tests.
Results: The average hatching ability of Aedes aegypti eggs ranged from 82.4% to 100%, with no significant differences between treatment and control groups or across generations. Larval development and eclosion (adults formed) percentages also showed no significant differences. Predominantly observed esterase bands were type "a" (black) esterase 3. Chi-square analysis revealed a significant difference only in esterase band “2” between the control and sand-based water treatment groups, with no significant differences in esterase bands 1 and 3 between groups. These findings highlight the importance of esterase patterns in understanding Aedes aegypti's breeding capacity in different water conditions, providing valuable insights into their adaptability and potential impact on disease transmission.
Conclusion: Aedes aegypti’s fecundity, hatching, and larval development vary slightly by water type, with genetic differences in esterase patterns. These insights aid mosquito control and disease prevention efforts.
Management of abdominal pregnancy with placenta left in situ
Authors: Indrayanti Sofiana , Hanifa Erlin Dharmayanti  , Muhammad Yusuf  , Ernawati
Published: January 2025

Introduction: Abdominal pregnancy is a rare form of ectopic pregnancy with a challenging diagnosis and management. We reported two cases of abdominal pregnancy with the placenta left in situ, which had different outcomes.
Case Presentation: Case one was a woman (P1A1) referred due to active bleeding after an emergency laparotomy for advanced abdominal pregnancy (36–37 weeks gestational age [GA]). The newborn (3300 g) was delivered alive, but the placenta was left in situ due to hemodynamic instability. Re-exploration surgery revealed a placenta in the abdominal cavity, covering the caecum and ileocaecal junction. The placenta was left due to high suspicion of infiltration into the retroperitoneum and hemodynamic instability. Serial β-hCG levels declined progressively but increased again at day 48. A methotrexate regimen (20 mg/day) for five days was given, and the level was 6.03 mIU/ml on day 94. However, the abdominal wound was still seeping even after 12 months post-operatively due to suspicion of fistula formation. The placenta was fully absorbed after 14 months post-operative.
Case two was a woman (G2P1) referred due to ectopic pregnancy and fetal demise at 14-15 weeks GA. Emergency laparotomy revealed abdominal pregnancy. The placenta was also left intra-abdominal due to active bleeding in the implantation area. The serial β-hCG declined progressively, with no neovascularization, and the placenta was fully absorbed four months and six months after the operation, respectively.
Conclusion: In managing abdominal pregnancy with placenta left in situ, periodic quantitative β-hCG, ultrasound examination of the placental size, and monitoring of surgical wounds are indispensable. Chemotherapy must be initiated if there is a plateau or an increase of serial β-hCG level or neovascularization of placental Doppler.
Sarcopenia as an indicator of nutritional status and predictor of upper gastrointestinal cancer mortality at Dr. Sardjito Central Hospital
Authors: Prawirohardjo Arif Nurhidayat , Handaya Adeodatus Yuda , Setyawan Nurcahya , Utomo Bambang Purwanto
Published: January 2025

Link of Video Abstract: https://youtu.be/JUvgQGPXblo
 
Background: Sarcopenia is defined as a musculoskeletal disease generally characterized by loss of skeletal muscle mass, skeletal muscle strength, and physical performance. This study aims to determine sarcopenia as an indicator of nutritional status and predictor of mortality among patients with upper gastrointestinal cancer at Dr. Sardjito Hospital.
Methods: This study is a cross-sectional study using secondary data in medical records conducted from April to May 2023 at Dr. Sardjito Hospital Yogyakarta. The sample consisted of 32 patients and reached the inclusion & exclusion criteria. The data were subsequently analyzed through bivariate analysis with the Chi-Square test. Data were analyzed using SPSS version 25.0 for Windows.
Results: From the 32 study samples obtained, 81.3% had sarcopenia while the remaining 18.8% did not have sarcopenia; 31.3% of patients were categorized as underweight, 50% of patients were normal, and 18.8% of patients were overweight; and 59.4% of patients died while the remaining 40.6% lived. No significant association was found between sarcopenia and nutritional status (p=0.169). However, a significant association was observed between sarcopenia and mortality (p=0.029), with an odds ratio of 0.089.
Conclusion: Sarcopenia cannot be used as an indicator of the nutritional status of upper gastrointestinal cancer patients. However, it can serve as a predictor for mortality associated with the disease.
Molecular characterization and the virulence gene presence of uropathogenic Escherichia coli in the Indonesian community: the phylogeny groups and clinical manifestation
Authors: Suwarsono Erike Angggraini , Soebandrio Amin , Karuniawati Anis , Bela Budiman , Shahab Nouval , Lie Khie Chen , Rosana Yeva , Arozal Wawaimuli , Prihantono Joedo
Published: January 2025

Link of Video Abstract: https://youtu.be/X3877wT108E
 
Background: Uropathogenic Escherichia coli (UPEC) is the most prevalent pathogen in Community-acquired Urinary Tract infections (Ca-UTI) with a divergent spectrum of clinical diseases. Molecular characterization of the virulence gene and the phylogeny group of UPEC could elucidate the broad spectrum of clinical manifestations associated with this pathogen, ranging from asymptomatic bacteriuria to urosepsis.
Method: This study collected clean catch urine samples from Ca-UTI patients between 2019 and 2020. The urine sample was inoculated onto blood sheep and MacConkey agar and incubated overnight. A colony was selected for phenotypic and antimicrobial sensitivity testing using Vitex2. All isolates identified as E.coli were validated by the 16S specific gene of E.coli using Taqman real-time PCR. Furthermore, virulence genes fimH, sfaS, pap C, cnf-1, and hlyA were identified using real-time PCR, followed by a phylogeny group, according to Clermont. All those data were analyzed descriptively.
Results: This study involved the collection of 188 urine samples from patients with Ca-UTI, and 54 isolates were confirmed to be true E.coli, and the B2 phylogeny group was observed to be the most dominant in cystitis (42%) and pyelonephritis (73%). However, groups A and B1 didn’t appear in pyelonephritis patients. Both sfaS and hly-A were virulence genes detected in the B2 and D groups. Gene fimH that encoded adherence factor was seen in all phylogeny groups.
Conclusions: Based on the result, it can be concluded that B2 is the dominant phylogeny group in Ca-UTI, sfaS and hlyA is a virulence gene responsible for pyelonephritis, and fimH is the adherence factor in all isolates.
Signal peptides for optimalization secretion of recombinant protein: An innovation to produce bone morphogenetic protein-2 in mesenchymal stem cells
Authors: Fahdia Mazfufah Nuzli , Nurhayati Retno Wahyu , Dilogo Ismail Hadisoebroto , Anggraini Dian , Mubarok Wildan
Published: January 2025

Bone morphogenetic protein 2 (BMP-2) is a protein or growth factor that plays an important role in osteogenic differentiation. Recently, there is an increasing demand for BMP-2, as it is the only osteoinductive growth factor approved by the Food and Drug Administration (FDA) as a substitute for bone grafts. However, recombinant BMP-2 production suffers from low production yields and changes in the biological function of the protein due to the low efficiency of translocation in production hosts. One of the key regulators that influences the efficiency of protein translocation is the signal peptide (SP). SP regulates the process of post-translational protein modification, which determines the fate of the synthesized protein. This literature review aims to explore the role of SP in the process of recombinant protein production in mammalian cells and the utilization of SP in BMP-2 production in the secretome of mesenchymal stem cells (MSCs). The production of recombinant proteins in the MSC secretome is expected to be an innovative therapy because it combines the positive effects of the secretome and BMP-2 together for bone healing.
Abdominal tuberculosis with multi-organ involvement in CT imaging: a unique and rare case report
Authors: Amalia Puri Handayani  , Muhammad Hidayat Surya Atmaja
Published: January 2025

Link of Video Abstract: https://youtu.be/T1AM2QgdclM
 
Background: Abdominal tuberculosis, accounting for 5% of global cases, is one of the most common forms of extrapulmonary tuberculosis. It can affect various parts of the abdomen, single or multi-organ involvement. Accurately identifying the proper diagnosis poses a significant challenge due to the wide range of clinical and radiological manifestations that resemble other diseases, potentially leading to treatment delays. In this case report, we present a sporadic and particular case of abdominal tuberculosis with multi-organ involvement, highlighting key CT imaging features for diagnosis.
Case Presentation: A sixteen-year-old girl presented to our center with a distended abdomen and a growing lump in the left waist that had been progressing for three months, anorexia, and weight loss. CT scan examination showed abdominal tuberculosis with multi-organ involvement, with unique and rare features of tuberculous peritonitis, tuberculous lymphadenitis, tuberculous hepatosplenic, and tuberculous retroperitoneal abscess. CT scan findings in abdominal tuberculosis have a classification for each organ involvement to aid in concluding the disease. Several findings, such as mesenteric cysts, calcified subcapsular hepatic nodules, splenic microabscesses, and retroperitoneal abscesses with osteoarticular involvement, are unique and rare findings in abdominal tuberculosis.
Conclusion: CT scan holds a substantial role in interpreting and diagnosing abdominal organ involvement in tuberculosis, and with mandatory proper understanding in discerning all findings, leading physicians in making decisions regarding patient management.
Immediate effects of gait biofeedback on peak plantar pressure in patients with type 2 diabetes mellitus with diabetic neuropathy
Authors: Prasetyanto Ingrid Melinda , Pawana I Putu Alit , Arfianti Lydia , Utomo Budi
Published: January 2025

Link of Video Abstract: https://youtu.be/91dLGOg7wjc
 
Background: Treatment that can be done to prevent ulceration in diabetic feet is reducing high pressure in the foot area. One strategy that is currently being developed is biofeedback on gait patterns. Scientific evidence regarding the use of biofeedback in cases of diabetic neuropathy is still sparse, but it is a promising rehabilitation strategy to improve biomechanical deficits in gait patterns and allow subjects to initiate new gait strategies using visual and/or auditory information.
Methods: This study is a pre-experimental research design before and after the intervention of giving biofeedback on walking patterns to 20 subjects with diabetic neuropathy who met the inclusion criteria and did not have exclusion criteria, measured plantar pressure at the beginning of the examination, and immediately after giving biofeedback on gait patterns.
Results: The initial value of peak plantar pressure in the total area was high (more than 200 kPa). The initial value of peak plantar pressure in the 4 areas analyzed (heel, midfoot, forefoot, and big toe) was found to be in the range of 100-200 kPa, while the initial value of peak plantar pressure in the toes area was found to be <100 kPa. Immediately after administering biofeedback, the walking pattern showed a significant decrease in peak plantar pressure values in the total area, heel, and big toe compared to the initial value (p-value= 0.001, 0.012, 0.00). There was no significant decrease in peak plantar pressure values in the midfoot and toe areas.
Conclusions: A significant reduction was achieved in the average plantar pressure in the heel, big toe, and overall area. This supports the recommendation to provide walking pattern biofeedback in diabetic neuropathy patients.
The effect of Vivifrail© multicomponent exercises on handgrip strength and upper limb endurance in elderly with frailty syndrome in the nursing home: a quasi-experiment study
Authors: Mawadda Idia , Andriana Meisy , Nugraheni Nuniek , Subadi Imam , Utomo Dwikora Novembri , Melaniani Soenarnatalina
Published: January 2025

Background: Elderly with frailty syndrome has emerged as a health focus as life expectancy increases worldwide. Physical exercise, including Vivifrail multicomponent exercise, has been proven to improve frailty status in the elderly. Hand grip strength and upper limb endurance are important factors that affect the daily activities, general strength, and frailty condition of the elderly.
Objective: Analyzing the effect of Vivifrail multicomponent exercises on hand grip strength (HGS) and endurance muscles in the upper extremities in the elderly with frailty syndrome in a nursing home in Surabaya, Indonesia.
Methods: This research design uses a pre-test and post-test study design with a proportional random sampling of 50 participants (treatment group = 25 and control group = 25). Data collected included HGS and arm curl test (ACT). The treatment group got Vivifrail multicomponent exercise 5 ×/weeks for four weeks. Both groups received a conventional exercise routine of around 15 minutes daily. Statistical tests include paired t-tests and independent t-tests with p <0.05.
Results: There was a difference in treatment group in HGS value between pre-test (17.42 ± 5.05) and post-test (20.48 ± 6.39; t = -4.644; CI 95% = -4.419 – -1.699; p <0.001). Similar conditions were also found in the ACT value: a pre-test of 18.6 ± 3.45 and a post-test of 22.6 ± 4.68 (t = -5.520; CI 95% = -5.605 – -5.520; p <0.001). A significant comparison between treatment and control groups was found in ΔHGS (t = 4.544; CI 95% = 1.868 – 4.834; p <0.001) and ΔACT value (t = 1.474; CI 95% = -0.758 – 4.918; p = 0.147).
Conclusion: Vivifrail multicomponent exercises significantly impact HGS and endurance muscles in the upper extremities in the elderly with frailty syndrome.
Profile of pyogenic hepatic abscess patients at Dr. Soetomo General Hospital, Surabaya
Authors: Setyaningrum Aisyah Dewi , Danardono Edwin , Wibowo Marjono Dwi
Published: January 2025

Introduction: Liver abscess (LA) is the formation of a pus-filled cavity in the liver parenchyma due to bacterial, fungal, or parasitic infection and is one of the most common tropical diseases of the gastrointestinal tract. Liver abscesses are classified as pyogenic liver abscess (PLA) or amoebic LA. Antibiotics and drainage are first and most important in managing hepatic abscesses. This study aims to determine the profile of hepatic abscess patients at Dr. Soetomo General Hospital, Surabaya, 2017-2022
Method: This research is an observational study with a cross-sectional research design. The data of this study were collected from medical records of patients with pyogenic hepatic abscesses at Dr. Soetomo General Hospital, Surabaya, in 2017-2022.
Results: This study found liver abscesses more common in patients aged 31-40 (27.5%). Male subjects with hepatic abscesses showed a higher percentage (82.5%) than females (17.5%). Most patients performed subcutaneous drainage management in 26 (65%) subjects, while 14 (35%) subjects performed surgical drainage. Bacterial cultures were performed on 40 patients diagnosed with hepatic abscess, and 6 cultures (15%) had no bacterial growth, while 34 cultures (85%) had microorganism growth. Of the 34 cultures with bacterial growth, the most bacterial growth was Escherichia coli (32.5%), and the least bacterial growth was Candida albicans (2.5%) and Pseudomonas sp. (2.5%).
Conclusion: In this study, hepatic abscess patients at Dr. Soetomo General Hospital, Surabaya, in 2017-2022, mainly occurred in patients aged 31-40 and female. In addition, this study also showed that most patients were treated with subcutaneous drainage compared to surgical drainage. Bacterial growth cultures were found in most patients, with Escherichia coli bacteria being the most prevalent.
Predicting bacillary load in clinically suspected pulmonary tuberculosis patients in Indonesia using Xpert MTB/RIF CT values
Authors: Sasmanto Suharyadi , Mertaniasih Ni Made , Koendhori Eko Budi
Published: January 2025

Link of Video Abstract: https://youtu.be/EKJS5Twc8aU
 
Background: Smear microscopy has been employed for calculating bacillary load in pulmonary tuberculosis (TB). Nevertheless, the requirement for an innovative diagnostic approach is underscored by the limited sensitivity and specificity of smear microscopy. This study aims to investigate the interrelation of Xpert MTB/RIF CT value with AFB smear results, culture examination, and chest X-ray (CXR) findings.
Methods: This is a cross-sectional study using sputum samples from patients clinically diagnosed with pulmonary TB. Each sample underwent AFB microscopic evaluation, culture, and colony counting, as well as Xpert MTB/RIF assay. Chest X-ray results were obtained from electronic medical records. Correlations between two variables were assessed using Spearman’s test and cut-off values were determined using ROC analysis.
Results: Out of a collective 45 specimens of sputum, 80% exhibited positive AFB smear results. We found a strong correlation between each raw-CT and N-CT and positive AFB smear results (r = 0.676 and -0.650, respectively; p < 0.05). A cut off of ≤ 28.3 for raw-CT produced 91.7% sensitivity and 55.6% specificity, while > -1 for N-CT produced 77.8% and 88.9%. Moderate correlations were found between raw-CT and N-CT (r=0.412 and -0.392, respectively) and the presence of cavities on CXR, while weak correlations were found (r=0.367 and -0.385, respectively) for consolidations.
Conclusions: Positive AFB smear results in pulmonary TB correlate strongly with the Xpert MTB/RIF CT value. This put further emphasis on the utilization of Xpert MTB/RIF CT value to substitute for AFB smear as a measure of bacillary load.
Photochemical Tissue Bonding using Rose Bengal as a novel strategy on suture-less tendon repair: A systematic review
Authors: Waluyo Yose , Muchsin Diah Nurul Islami , Rosadi Yaldi , Darmawan Rizki
Published: January 2025

Introduction: Suturing is currently the gold standard for repairing a ruptured tendon. Sutures, on the other hand, can cause complications such as further injury, restriction of blood and nutrition supply, inflammation, rejection of foreign entities (sutures), scarring, and adhesions, which can lead to functional impairment. Another approach has been proposed called Photochemical Tissue Bonding (PTB). The aim of this study is to review the current literature of photochemical tissue bonding using rose bengal as a novel method on tendon repair.
Methods: All searches of the electronic database will be conducted using keywords appropriate to each database. A comprehensive literature search was conducted on MEDLINE, ScienceDirect and Google Scholar from inception to June 2022.
Results: We included three studies out of 278 relevant studies that were found. One study assessed the ultimate strength of tendon repair using PTB, one study assessed the ultimate strength, functional outcome and histological findings, and the last one assessed the histological findings only. All of these studies showed good outcome of using PTB in tendon repair
Conclusion: In this review we conclude that PTB has enough advantage on tendon repair based on the in vitro and in vivo experimental study which evaluated its ultimate strength, functional outcome, and histological findings in tendon repair. Although the difference of ultimate strength is not significant, but, repaired tendon by using PTB showed lower adhesive score that can improve functional outcome of the tendon.
Bitter Melon's fruit extract (Momordica charantia Linn.) decrease oxidative stress in hyperglycemic trophoblastic cell
Authors: Gondo Harry , Haryanti Elizabeth
Published: January 2025

Background: Oxidative stress is a condition of imbalance between the amount of oxidants and antioxidants in the body. In preeclampsia pregnancy, hyperglycemia was known as main suspect in its pathomechanism.  Bitter melon was perennial plant grown in Indonesian village and widely used traditionally as diabetic treatment. However, there is no adequate information regarding its effect in hyperglycemic pregnancy.  This study aimed to determine the effect of bitter melon extract in a hyperglycemic trophoblastic cell culture.
Methods: Human placenta was obtained from the cesarean delivery process after parent consent. Isolation and  culture of trophoblasts cells is carried out using enzymatic process.After confluent, trophoblastic cells was extracted and added to bitter melon extract in four groups of treatment. Administration of bitter melon fruit extract on trophoblastic cell culture in a hyperglycemic environment. After 8 hours, supernatant was collected and analyzed for superoxide dismutase and malondialdehyde. One Way Anova test was carried out to determine the significance value of the treatment of trophoblastic cell culture.
Result: The administration of bitter melon extract at a dose of 0.8 mg / ml has the highest average value of 191.6000 U/mL. This shows the effect of bitter melon extract on increasing SOD while MDA decreased by 3900.0000 U/mL which is close to the negative group. The greater the dose of bitter melon extract given, the higher the effect on SOD activity, conversely, the greater the dose of bitter melon extract given can reduce MDA activity.
Conclusion: Bitter melon fruit extract decreases oxidative stress in hyperglycemic trophoblastic cells.
Primary living donor liver transplantation outcome in biliary atresia patients: A single-center retrospective study from Indonesia
Authors: Rinaldhy Kshetra , Fitria Diana , Tamba Riana Pauline , Widyani Ni Made Sarastri
Published: January 2025

Background: Biliary atresia (BA) is the leading indication for liver transplantation in pediatric patients. Delayed diagnosis of BA in Indonesia causes the primary living donor liver transplantation (LDLT) rate to be higher than the other transplant centers worldwide. This study aimed to assess the primary LDLT outcome in BA patients in Cipto Mangunkusumo Hospital (CMH) and the associated influencing factors.
Methods: This was a retrospective cohort study of pediatric BA patients who underwent primary LDLT from 2010 to 2019 in CMH. The observed data started from initial admission through initial discharge. The preoperative factors included in the analyses were age at transplant, sex, nutritional status, and Pediatric End-Stage Liver Disease Score. Morbidity and mortality were analyzed for preoperative and intraoperative prognostic factors.
Results: 31 primary LDLT subjects were included in this study. The majority were males with a median age of 14 months and a mean PELD score of 17.09. Complications occurred in 96.7% of subjects with infection (90.3%) as the most common complication. Relaparotomy was performed in 54.8% of subjects. The median length of stay was 41 days. One-year post-transplantation mortality was 9.3%. There were statistically significant correlations between nutritional status and infection incidence (p = 0.003).
Conclusion: Infection is the most common complication in primary LDLT patients in CMH with nutritional status serving as the influencing factor. Despite the complication rate, the one-year mortality rate is comparable to other transplantation centers worldwide. The incidence of relaparotomy and infectious complications are still major problems in newer, resource limited centers.
Correlation between degree of fatty liver and osteocalcin levels with bone mineral density in young women with central obesity
Authors: Ningrum Farah Hendara , Riwanto Ignatius , Sukmaningtyas Hermina , Adi Kusworo
Published: January 2025

Background: Central obesity is a risk factor for other diseases including type 2 diabetes mellitus, cardiovascular disease, and is a major risk factor for Non-Alcoholic Fatty Liver Disease (NAFLD). Obesity and NAFLD can affect bone mass density through inflammatory pathways. The increased prevalence of obesity allows the risk of NAFLD and the increased prevalence of NAFLD is associated with an increased risk of decreased BMD where women are more prone to osteoporosis. Nutritional status of overweight and obesity can affect the level of osteocalcin. In an effort to prevent osteoporosis, measurement of serum osteocalcin levels can be used as a screening tool in detecting conditions of low bone mass. This study aimed to determine and analyze the relationship between fatty liver and osteocalcin levels with BMD in young women with central obesity.
Methods: The design of this study was cross sectional with the target population being middle-aged women (30-49 years) with central obesity. The degree of fatty liver was examined using the ultrasound method. Osteocalcin levels were measured by taking blood to be tested using the enzyme-linked immunosorbent assay (ELISA) method. Bone Mass Density examination was carried out using DXA. Data were analyzed using SPSS 18.0 that include normality test using Kolmogorov Smirnov, and correlation test using Spearman rank test.
Results: Central obesity which can be seen using the parameters of waist circumference and height ratio (WHtR) is negatively correlated with bone mineral density (BMD) (p=0.025; r=-0.268) and positively correlated with the incidence of non-alcoholic fatty liver disease (NAFLD) (p=0.005; r=0.331). Osteocalcin is negatively correlated with bone density in obese women, but this correlation is not significant after statistical tests (p=0.615; r=-0.061). This study also shows that osteocalcin and obesity do not have a significant positive correlation after statistical tests (p=0.088; r=0.025).
Conclusion: Significant correlation was found between WHtR and BMD.
New detection methods of early-onset preeclampsia in pregnant women with cardiovascular disease risk factors
Authors: Mukminah Aisyatul , Sargowo Djanggan , Rahardjo Bambang , Sujarwoto Sujarwoto , Nurwidyaningtyas Wiwit
Published: January 2025

Background: Surveillance in high-risk pregnancies is inconsistent. The carefully calculated identification of associated preeclampsia risk factors is promising for use as a basis for the early management of pregnant women at risk. The aims of this study was to develop a risk index for determining preeclampsia in pregnant women with high risk.
Methods: We performed a prospective, multicenter, observational study to validate the risk factor of preeclampsia with an Odds Ratio (OR) of ≥2 that would be predictive of the absence or presence of preeclampsia (> 20 weeks of gestation until 6 weeks postpartum).
Results: In the development cohort (305 women), we identified the overall prevalence of preeclampsia as 3.6%. Older age at pregnancy, obesity, personal history of preeclampsia, family history of preeclampsia, chronic hypertension, and family history of hypertension as cardiovascular risk factors significantly affected the development of preeclampsia among the women studied.
Conclusion: Pregnant women with risk factors <2 had a negative predictive value for early-onset preeclampsia of 99.2%.
Early warning system in obstetrics, MEOWS: A systematic literature review
Authors: Sasmito Priyo , Pribadi Dimas Ria Angga , Juliastuti Dyah , Pamungkas Rian Adi , Setyowati Tri Agus , Jumintono Jumintono , Arifani Nisa , Sumartini Sri , Amalia Linda , Aljufri Salim , Prasetya Fika Indah
Published: January 2025

Introduction: Some versions of the Early Warning System (EWS) in the maternity field are used. This study aims to analyze the accuracy of the Modified Early Obstetric Warning System (MEOWS) in predicting adverse events, and its effectiveness in improving maternal care.
Methods: We searched for Midwifery Early Warning System research articles published in peer-reviewed journals between 2018 and 2023 on SCOPUS, Science Direct, Google Scholar, and Pub-Med. We also searched relevant article reference lists and professional community websites and analyzed the data with a narrative synthesis.
Results: Out of 676 papers, only 15 met the criteria. MEOWS has a high sensitivity (88.1%) and specificity (85.25%), but a low predictive value (68.63%) for detecting morbidity or Intensive Care Unit (ICU) admission. MEOWS accurately predicts mortality in critically ill obstetric patients. MEOWS increases the frequency of vital sign monitoring and facilitates prompt clinical action for abnormal observations, potentially reducing maternal morbidity.
Conclusion: MEOWS can predict severe morbidity and mortality in obstetric patients, improving care quality and outcomes. Its efficacy in reducing maternal mortality is limited, despite using clinical parameters available in resource-limited settings. Further research is needed to assess its impact.
relationship between allergic rhinitis and asthma in patients with rhinosinusitis
Authors: Metiananda Elvina , Hutahaean Fransiska , Panggabean Olivia
Published: January 2025

Introduction: Allergic rhinitis and asthma are the most common diseases worldwide, and both have interconnected inflammatory processes. Allergic Rhinitis (AR), asthma, and rhinosinusitis are closely related, where patients with a history of allergic rhinitis or asthma, or even both, can develop rhinosinusitis. This study aims to determine the relationship between allergic rhinitis and asthma with rhinosinusitis at Ibnu Sina Hospital, Gresik.
Methods: Total of 300 patients were enrolled in this study. Using the total sampling method, samples were selected from the entire population of rhinosinusitis patients who received outpatient or inpatient care at the THT-KL Clinic in Ibnu Sina Hospital, Gresik, during the period 2020-2022. Secondary data extracted from the patients’ medical records at Ibnu Sina Hospital, Gresik. Subsequently, the collected data was analyzed through Spearman's correlation test and multiple linear regression analysis.
Result: Significance was found between allergic rhinitis, asthma, and rhinosinusitis, with a p-value of 0.00 and a correlation coefficient of 0.599.
Conclusion: Significant relationship has been found between allergic rhinitis and asthma with rhinosinusitis in patients with rhinosinusitis undergoing outpatient or inpatient treatment at Ibnu Sina Hospital, Gresik, during the period of 2020-2022.
 
Keywords: Allergic Rhinitis, Asthma, Rhinosinusitis.
The associations of personal hygiene, closed contact shoes, and high physical activities with the incidence of superficial fungal foot infections: A cross sectional study in navy military students
Authors: Hertanti Dhea Medisika , Prakoeswa Cita Rosita Sigit , Sawitri Sawitri , Hidayati Afif Nurul , Utomo Budi , Rahmadewi Rahmadewi , Sidarta Jeffrey Agung , Ervianty Evy
Published: January 2025

Introduction: Superficial fungal foot infections is an infectious diseases resulting from dermatophyte, Candida spp., and molds. The risk factors of superficial fungal foot infections are believed from inadequate personal hygiene, frequent use of closed footwear, and high levels of physical activity. Purpose of this study is to investigate the correlation between risk factors and superficial fungal foot infections. An examination of the relationship between the Athletes Foot Severity Score (AFSS) and Dermatology Life Quality Index (DLQI) in military students was conducted to assess the impact on life quality index in individuals exhibiting elevated AFSS scores.
Methods: This is a cross-sectional analytic design with 194 military students as the population.  The sample was conducted through consecutive sampling. The inclusion criteria were military students in PUSLATDIKSARMIL exhibiting lesions on feet. Questionnaires were used to ascertain the risk factors associated with superficial fungal foot infections.
Results: This study involved 194 military students, mostly aged 17-25, in which 16.5% exhibited poor personal hygiene, while 74.2% reported wearing closed shoes for over 8 hours. The students demonstrated a high level of physical activity, with an IPAQ score of 26,880 Metabolic Equivalent of Tasks (MET) minutes/week. Notably, 22.7% had severe AFSS scores. Laboratory indicated 30.9% with positive KOH 20% and positive cultures, 27.8% with negative KOH 20% and positive cultures, and 9.3% with positive KOH 20% and negative cultures. Mold was the dominant fungal type affecting 68.4%. There is a correlation between closed contact shoes usage and superficial fungal foot infections. Significant correlation existed between AFSS scores and DLQI.
Conclusion: A strong correlation of the incidence of superficial fungal foot infections and the use of closed shoes were showed. A significant correlation was identified between the AFSS score and the DLQI.
Topical application of Tetragonula laeviceps stingless bee honey extract gel inhibits Malondialdehyde (MDA) levels and Matrix Metalloproteinase 1 (MMP-1) expression in rats (Rattus norvegicus) exposed to UVB radiation
Authors: Putra Anak Agung Gede Kresna Naria , Winaya Ketut Kwartantaya , Darmaputra I Gusti Nyoman
Published: January 2025

Introduction: Ultraviolet (UV) radiation, especially UVB radiation, can induce photoaging effects by increasing oxidative stress and degrading elastin and collagen fibers in the skin. Malondialdehyde (MDA) is one of the markers associated with increased oxidative stress, and matrix metalloproteinase-1 (MMP-1) is a marker related to elastin and collagen degradation. The development of photoaging-related modalities, particularly utilizing natural substances, has gained significant attention. Tetragonula laeviceps stingless bee honey has been studied for its various antioxidant contents and its role in anti-photoaging. This study aims to validate the antioxidant effects in photoaging by evaluating the impact of applying Tetragonula laeviceps stingless bee honey extract gel on MDA levels and MMP-1 expression in Wistar rats subjected to chronic skin inflammation induced by UVB exposure.
Methods: This study employed an experimental research design with a post-test only with a control group design. Thirty Wistar rats were used, divided into six control and treatment groups. The control groups consisted of negative control, control 1+, and control 2+, while the treatment groups received honey extract gel with concentrations of 30%, 55%, and 70%, respectively. The rats were exposed to UVB radiation for four weeks, and then skin tissue was collected to measure MDA levels and MMP-1 expression using an ELISA method. Data were analyzed using a one-way ANOVA with post hoc LSD, with a significance level set at p<0.05.
Result: The one-way ANOVA showed significant differences in the mean MDA levels (p=0.030) and MMP-1 expression (p=0.018) among the groups. Post hoc tests revealed that the 70% honey extract gel concentration significantly resulted in the lowest MDA levels and MMP-1 expression (p<0.05).
Conclusion: Tetragonula laeviceps stingless bee honey extract gel can inhibit the increase in MDA levels and MMP-1 expression in Wistar rats exposed to UVB radiation, with the 70% honey extract gel concentration showing the highest effectiveness in producing the lowest MDA levels and MMP-1 expression.
Abdominal blunt trauma patients profile at Dr. Soetomo General Hospital, Surabaya
Authors: Katherine Inomy Claudia , Danardono Edwin
Published: January 2025

Introduction: Blunt abdominal trauma is an injury to the abdomen without penetration into the peritoneal cavity, which can result from a blow, impact, blast, deceleration, or compression. Blunt abdominal trauma can occur at any age and is associated with high morbidity and mortality, found in approximately 7-10% of trauma patients. This research intends to examine the profile and factors that influence the outcome of blunt abdominal trauma patients at Dr. Soetomo General Hospital, Surabaya.
Methods: This observational cross sectional study was conducted at Dr. Soetomo General Hospital, Surabaya, from January to December 2022. This research method is descriptive based on medical records of blunt abdominal trauma.
Results: The total number of subjects who met the inclusion and exclusion criteria in this study was 67 subjects. In this study, it was found that blunt abdominal trauma caused the most trauma to solid organs (79%) than hollow organs (18%). In this study, it was found that blunt abdominal trauma caused the most trauma to the liver (43%), followed by the spleen (34%), jejunum (8.9%), and bladder (4%). Trauma to the kidney, rectum, and sigmoid was found in 2 (2.9%) subjects, while in the colon and duodenum in 1 (1.5%) subject.
Conclusion: Morbidity and mortality linked to blunt abdominal trauma can be lowered by implementing early diagnosis and a comprehensive multi-trauma approach.
Epigenetic Regulation In Melanogenesis Of Vitiligo
Authors: Sutrini Nyoman Ayu , Praharsini I Gusti Ayu Agung , Herawati Sianny , Lestari AA Wiradewi
Published: January 2025

Vitiligo is a skin disorder in well-defined depigmented macules due to the loss of melanin. Vitiligo is a complex ailment with multiple causative factors. Research into pathophysiology is ongoing, and there are several challenges. Environmental and oxidative stress are the most significant factors that lead to vitiligo. Eventually, this factor can also affect the epigenetic aspect. Epigenetics is defined as the changes of inherited phenotypic but does not change the DNA sequence. It consists of the DNA methylation process, histone modification, and deactivation of the non-coding RNA (ncRNA) process. A significant difference was found between the melanocyte cell line from vitiligo patients and the normal melanocyte cell line in research that compared the melanocytes of normal persons and those with vitiligo to assess DNA methylation. In vitiligo melanocytes, CpG established a bimodal methylation pattern, with the majority exhibiting hyper- or hypomethylation at 20 distinct loci. It looked at how vitiligo and normal individuals expressed distinct ncRNAs. A higher level of MITF expression, which is unrelated to melanogenesis, is correlated with higher expression of miR-21-5p (p<0.01). Conversely, the Sox5 level was seen as being low. One function of Sox5 is to inhibit MITF. Additionally, the vitiligo group's lncRNA Taurine-upregulated 1 (TUG1) expression was lower (0.4±0.19) than that of the control group (1.028 ±0.08).  It indicates the inhibition of melanogenesis by inhibiting the phosphorylation of the ERK/MAPK signaling pathway. In addition, histone modification also plays a crucial role in vitiligo. It is related to melanogenesis and mainly examines histone acetylation.
Exploring an electronic health promotion model for post-placental intrauterine device (IUD) birth control: A systematic review and meta-analysis
Authors: Sulistiyanto Henri , Soetrisno  , Subiyanto A.A , Setyowati Retno
Published: January 2025

Introduction: The poor utilization of intrauterine devices (IUDs), particularly post-placental IUDs, might be attributed to bias and insufficient information, as there is still a scarcity of comprehensive contraceptive counseling. For instance, by means of dialogues with physicians, textual literature, or audiovisual methods. This study aims to determine the effectiveness of an electronic intervention (video) in promoting the use of post-placental IUD contraception.
Method: The specified keywords generated a total of 509 results from Google Scholar, 33 from Pubmed, 14 from Science Direct, 88 from Sage Journal, 50 from Springer Links, 20 from Scopus, and 178 from Proquest.
Results: The bibliography listed 12 articles for systematic review and 5 articles for meta-analysis. Based on the heterogeneity test, the calculated ρ value is 0.88, which is greater than 0.05, and the I2 value is 0%. This indicates a uniformity in the variation across trials. The Random Effect Model produces a combined odds ratio of 1.07 with a 95% confidence interval of 0.26-4.39. The score of 0.93 suggests no significant difference between the treatment and control groups, with the data exhibiting homogeneity.
Conclusion: In conclusion, when compared to those who did not view videos, those who did watch videos had the potential to improve their knowledge, talents, and decision-making abilities in relation to post-placental IUDs.
Potential research themes related to clinical applications of curcumin nanoparticles for the brain based on bibliometric studies
Authors: Saleh Arman Yurisaldi , Prabowo Imam , Yogi Saputra Dwi Arwandi
Published: January 2025

Introduction: This study is the first to explore the clinical application of curcumin nanoparticles in brain-related therapies. This research was conducted through a bibliometric study of the Scopus database from 2011 to 2024. The main objective is to understand and analyze trends and developments in this field. Curcumin nanoparticles have shown great potential in various clinical applications, especially in brain-related therapies. By utilizing bibliometric studies, this research seeks to dig deeper into how curcumin nanoparticles have been used and developed in this context over time.
Methods: Data for this research was obtained from www.scopus.com and saved in.csv format. This data is then processed using bibliometric applications, namely Biblioshiny and VOSviewer. Quantitative and qualitative analyses were conducted to gain a better understanding of trends and developments in this field.
Results: The research results include the most cited documents, the most relevant authors, affiliations, network visualization, overlay visualization and density visualization, thematic maps, and the most contributed documents. All of this provides a clear picture of how research in this field has developed over time.
Conclusions: Our study provides a bibliometric overview of the research on curcumin nanoparticles and their potential applications for the brain. We identified the author, outputs, and themes in this field, as well as some niche and emerging themes that warrant further investigation. Our study can serve as a useful reference for researchers, policymakers, and practitioners who are interested in this promising area of nanomedicine.