bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of bioactive peptides from a Brazilian kefir sample, and their anti-Alzheimer potential in Drosophila melanogaster
Authors: Malta Serena Mares , Batista Letícia Leandro , Silva Heitor Cappato Guerra , Franco Rodrigo Rodrigues , Silva Matheus Henrique , Rodrigues Tamiris Sabrina , Correia Lucas Ian Veloso , Martins Mário Machado , Venturini Gabriela , Espindola Foued Salmen , da Silva Murilo Vieira , Ueira-Vieira Carlos
Published: June 2022

Alzheimer’s disease (AD) is the most common form of dementia in the elderly, affecting cognitive, intellectual, and motor functions. Different hypotheses explain AD’s mechanism, such as the amyloidogenic hypothesis. Moreover, this disease is multifactorial, and several studies have shown that gut dysbiosis and oxidative stress influence its pathogenesis. Knowing that kefir is a probiotic used in therapies to restore dysbiosis and that the bioactive peptides present in it have antioxidant properties, we explored its biotechnological potential as a source of molecules capable of modulating the amyloidogenic pathway and reducing oxidative stress, contributing to the treatment of AD. For that, we used Drosophila melanogaster model for AD (AD-like flies). Identification of bioactive peptides in the kefir sample was made by proteomic and peptidomic analyses, followed by in vitro evaluation of antioxidant and acetylcholinesterase inhibition potential. Flies were treated and their motor performance, brain morphology, and oxidative stress evaluated. Finally, we performed molecular docking between the peptides found and the main pathology-related proteins in the flies. The results showed that the fraction with the higher peptide concentration was positive for the parameters evaluated. In conclusion, these results revealed these kefir peptide-rich fractions have therapeutic potential for AD.
Impact of complex boundary on the hydrodynamic properties of methane nanofluidic flow via non-equilibrium multiscale molecular dynamics simulation
Authors: Jiang Chuntao , Li Wuming , Liu Qingsheng
Published: June 2022

Understanding the impact of complex boundary on the hydrodynamic properties of methane nanofluidic is significant for production optimization and design of energy-saving emission reduction devices. In the molecule scale, however, the microscopic mechanisms of the influence of the complex boundary on the hydrodynamic characteristics are still not well understood. In this study, a mixture boundary Poiseuille flow model is proposed to study the hydrodynamic properties and explore the molecular mechanisms of confined methane nanofluidic using the Non-equilibrium multiscale molecular dynamics simulation (NEMSMD). In order to investigate the influences of nonslip and rough boundary on hydrodynamic behavior of nanofluidic by the present model in one simulation, the coordinate transformation methods regarding the local symmetry is showed. Simulation results show that the atom number density, velocity and temperature profiles present significant differences near the nonslip boundary and rough wall surface. Moreover, the slip length of methane nanofluidic near the rough boundary decreases with the increasing of the temperature. Furthermore, the viscosity values are calculated by parabolic fit of the local velocity data based on the present model, which demonstrates that the impact of the nonslip boundary on the shear viscosity compared with the experiment result is less than one obtained using the rough boundary. In addition, the local contours of rotational and translational energy are plotted, which show that the rotational and translational energies of nonslip boundary are obvious higher than those of rough boundary. These numerical results are very significant in understanding the impact of complex boundary conditions on hydrodynamic properties in nanofluidic theory and the design of nano-devices.
Novel multi-mode shortwave broadcast transmitting antenna array
Authors: Yao Wang , Gao Huotao , Tian Ying , Lu Taoming , Zhang Xiaolin
Published: June 2022

Currently, shortwave broadcasting in the range of 5.9–26.1 MHz remains a relatively large blind spot within 900 km owing to the limitations of ionospheric characteristics. Reducing the emission frequency is a feasible approach for covering blind spots and improving broadcast performance. Thus, a new type of shortwave broadcasting antenna array capable of reducing the lowest emission frequency to 4.4 MHz is proposed in this paper. An electromagnetic simulation software is used to optimize the design. The simulation analysis shows that for the 4 × 4 multi-mode shortwave broadband transmitting antenna array, the gain obtained is 12–23.5 dB in the 4.4–27.4 MHz frequency band, and the VSWR for each mode is lower than 2.5. The radiation patterns at 5.9 MHz and 4.4 MHz on a vertical plane are compared, and the results prove that the radiation elevation angle of the new transmitting array increases significantly. The larger elevation angle and lower frequency ensure the enhancement of close-range coverage. A scale model prototype is fabricated and characterized, and the results of the measurement agree well with those of the simulations. It provides a theoretical basis and technical support for the improved design of broadband high-power shortwave broadcasting transmitting antenna systems.
Robust 3D lane detection in complex traffic scenes using Att-Gen-LaneNet
Authors: Jiang Yanshu , Dong Qingbo , Deng Liwei
Published: June 2022

Robust 3D lane detection is the key to advanced autonomous driving technologies. However, complex traffic scenes such as bad weather and variable terrain are the main factors affecting the robustness of lane detection algorithms. In this paper, a generalized two-stage network called Att-Gen-LaneNet was proposed to achieve robust 3D lane detection in complex traffic scenes. The Efficient Channel Attention (ECA) module and the Convolutional Block Attention Module (CBAM) were combined in this network. In the first stage of the network, we improved the semantic segmentation network ENet and proposed the weighted cross-entropy loss function to solve the problem of ambiguous distant lane segmentation. This method improved Pixel Accuracy to 99.7% and MIoU to 89.5%. In the second stage of the network, we introduced the interpolation loss function to achieve accurate lane fitting. This method outperformed existing detection methods by 6% in F-score and Average Precision on the Apollo Synthetic dataset. The proposed method achieved better overall performance in 3D lane detection and was applicable to broader and more complex traffic scenes.
Analysis of the entire mitochondrial genome reveals Leber’s hereditary optic neuropathy mitochondrial DNA mutations in an Arab cohort with multiple sclerosis
Authors: Al‐Kafaji Ghada , Alharbi Maram A. , Alkandari Hasan , Salem Abdel Halim , Bakhiet Moiz
Published: June 2022

Several mitochondrial DNA (mtDNA) mutations of Leber's hereditary optic neuropathy (LHON) have been reported in patients with multiple sclerosis (MS) from different ethnicities. To further study the involvement of LHON mtDNA mutations in MS in the Arab population, we analyzed sequencing data of the entire mitochondrial genome from 47 unrelated Saudi individuals, 23 patients with relapse-remitting MS (RRMS) and 24 healthy controls. Ten LHON mutations/variants were detected in the patients but were absent in the controls. Of them, the common primary pathogenic mutation m.14484T>C and the rare mutation m.10237T>C were found in one patient, whereas the rare mutation m.9101T>C was found in another patient. The remaining were secondary single nucleotide variants (SNVs) found either in synergy with the primary/rare mutations or individually in other patients. Patients carrying LHON variants also exhibited distinct mtDNA variants throughout the mitochondrial genome, eight were previously reported in patients with LHON. Moreover, five other LHON-related SNVs differed significantly in their prevalence among patients and controls (P < 0.05). This study, the first to investigate LHON mtDNA mutations/variants in a Saudi cohort may suggest a role of these mutations/variants in the pathogenesis or genetic predisposition to MS, a possibility which needs to be explored further in a large-scale.
Experimental and modeling analyses of COD removal from industrial wastewater using the TiO2–chitosan nanocomposites
Authors: Heydari Orojlou Shahin , Rastegarzadeh Saadat , Zargar Behrooz
Published: June 2022

In the present study, titanium oxide (TiO2) nanoparticles, chitosan, and several nanocomposites containing different mass dosages of TiO2 and chitosan have been applied as the adsorbent for COD removal from the industrial wastewater (Bouali Sina Petrochemical Company, Iran). The FESEM, XRD, and FTIR tests have been employed to characterize TiO2 nanoparticles, chitosan, and fabricated nanocomposites. Then, the effect of adsorption parameters, including TiO2–chitosan mass ratio (1:1, 1:2, and 2:1), adsorbent content (0.25–2.5 g), temperature (20–50 °C), pH (3–11), solution volume (100–500 mL), and contact time (30–180 min) on the COD reduction has also been monitored both experimentally and numerically. The Box–Behnken design of the experiment approves that TiO2–chitosan (1:1), adsorbent content of 2.5 g, temperature = 20 °C, pH 7.4, solution volume of 100 mL, and contact time = 180 min are the condition that maximizes the COD removal (i.e., 94.5%). Moreover, the Redlich–Peterson and Pseudo-second order models are the best isotherm and kinetic scenarios to describe COD removal’s transient and equilibrium behaviors. The maximum monolayer COD adsorption capacity of the TiO2–chitosan nanocomposite is 89.5 mg g−1. The results revealed that the industrial wastewater COD is better to remove using the TiO2–chitosan (1:1) at temperature = 20 °C.
Gram-negative multidrug-resistant organisms were dominant in neurorehabilitation ward patients in a general hospital in southwest China
Authors: Jiang Wei , Li Lang , Wen Siyang , Song Yunling , yu Lehua , Tan Botao
Published: June 2022

This study aimed to investigate the prevalence of and risk factors for multidrug-resistant organism (MDRO) infection in the rehabilitation ward of a general hospital in Southwest China. We analyzed rehabilitation patients with nosocomial infections caused by MDROs from June 2016 to June 2020. MDRO infection pathogens and associated antibiotic resistance were calculated. Possible risk factors for MDRO-related infection in the neurorehabilitation ward were analyzed using chi-square, and logistic regression. A total of 112 strains of MDRO were found positive from 96 patients. The MDRO test-positive rate was 16.70% (96/575). Ninety-five MDRO strains were detected in sputum, of which 84.82% (95/112) were gram-negative bacteria. Acinetobacter baumannii (A. Baumannii), Pseudomonas aeruginosa (P. aeruginosa), and Klebsiella pneumonia (K. pneumonia) were the most frequently isolated MDRO strains. The logistic regression model and multifactorial analysis showed that long-term (≥ 7 days) antibiotic use (OR 6.901), history of tracheotomy (OR 4.458), and a low albumin level (< 40 g/L) (OR 2.749) were independent risk factors for the development of MDRO infection in patients in the rehabilitation ward (all P < 0.05). Gram-negative MRDOs were dominant in rehabilitation ward patients. Low albumin, history of a tracheostomy, and long-term use of antibiotics were independent risk factors for MRDO infection and are worthy of attention.
Light regulates chlorophyll biosynthesis via ELIP1 during the storage of Chinese cabbage
Authors: Wang Tuoyi , Liu Sijia , Tian Shaonan , Ma Tianyi , Wang Wei
Published: June 2022

Chlorophyll loss is a major problem during green vegetable storage. However, the molecular mechanism is still unclear. In this study, a 21 days of storage experiments showed chlorophyll content was higher in light-stored Chinese cabbage (Brassica chinensis L.) leaves than those in dark-stored samples. Transcriptome analyses were performed on these samples to determine the effects of light. Among 311 differentially expressed genes (DEGs), early light-induced protein 1 (ELIP1) was identified as the main control gene for chlorophyll synthesis. Tissues and subcellular localization indicated that ELIP1 was localized in the nucleus. Motifs structure analyses, chromatin immunoprecipitation (ChIP) assays, luciferase reporter assays, and overexpression experiments demonstrated that ELIP1 regulated the expressions of genomes uncoupled 4 (GUN4), Glutamyl-tRNA reductase family protein (HEMA1), and Mg-protoporphyrin IX methyltransferase (CHLM) by binding to G-box-like motifs and affected chlorophyll biosynthesis during the storage of Chinese cabbage. It is a possible common tetrapyrrole biosynthetic pathway for chlorophylls, hemes, and bilin pigments in photosynthetic organisms. Our research also revealed that white light can be used as a regulatory factor to improve the storage ability and extent shelf life of Chinese cabbage.
Role of GBP1 in innate immunity and potential as a tuberculosis biomarker
Authors: Shi Ting , Huang Linlin , Zhou Yulin , Tian Jianmei
Published: June 2022

Tuberculosis (TB) is a global health problem of major concern. Identification of immune biomarkers may facilitate the early diagnosis and targeted treatment of TB. We used public RNA-sequencing datasets of patients with TB and healthy controls to identify differentially expressed genes and their associated functional networks. GBP1 expression was consistently significantly upregulated in TB, and 4492 differentially expressed genes were simultaneously associated with TB and high GBP1 expression. Weighted gene correlation analysis identified 12 functional modules. Modules positively correlated with TB and high GBP1 expression were associated with the innate immune response, neutrophil activation, neutrophil-mediated immunity, and NOD receptor signaling pathway. Eleven hub genes (GBP1, HLA-B, ELF4, HLA-E, IFITM2, TNFRSF14, CD274, AIM2, CFB, RHOG, and HORMAD1) were identified. The least absolute shrinkage and selection operator model based on hub genes accurately predicted the occurrence of TB (area under the receiver operating characteristic curve = 0.97). The GBP1-module-pathway network based on the STRING database showed that GBP1 expression correlated with the expression of interferon-stimulated genes (GBP5, BATF2, EPSTI1, RSAD2, IFI44L, IFIT3, and OAS3). Our study suggests GBP1 as an optimal diagnostic biomarker for TB, further indicating an association of the AIM2 inflammasome signaling pathway in TB pathology.
Utilizing native lignin as redox-active material in conductive wood for electronic and energy storage applications
Authors: Tran Van Chinh , Mastantuoni Gabriella G. , Belaineh Dagmawi , Aminzadeh Selda , Berglund Lars A. , Berggren Magnus , Zhou Qi , Engquist Isak
Published: June 2022

Utilizing native lignin as redox-active material in conductive wood electrodes for electronic and energy storage applications.
A novel symmetric pyrazine (pyz)-bridged uranyl dimer [UO2Cl3(H2O)(Pyz)0.5]22−: synthesis, structure and computational analysis
Authors: Byrne Nicole M. , Schofield Mark H. , Cahill Christopher L.
Published: June 2022

Characterization of the pyrazine-bridged uranyl dimer of (HPyz+)2[UO2Cl3(H2O)(Pyz)0.5]2·2H2O, featuring a delocalized π-system and stronger UO bonds than those present in the more typically observed [UO2Cl4]2− monomer.
Coupling a rotating biological contactor with an anaerobic baffled reactor for sustainable energy recovery from domestic wastewater
Authors: Mohammed Mona , Sills Deborah L.
Published: June 2022

A rotating biological contactor oxidized dissolved methane in effluent from an anaerobic baffled reactor, reducing life cycle environmental impacts on climate change.
Whole grain germinated brown rice regulates intestinal immune homeostasis and gastrointestinal hormones in type 2 diabetic patients—a randomized control trial
Authors: Ding Qi , Ren Junli , Zhou Yingying , Bai Zhihuai , Yan Jielin , Na Guanqiong , Shan Yujuan
Published: June 2022

Whole grains present distinguished benefits to a handful of metabolic syndromes (MetS).
Green chemistry and first-principles theory enhance catalysis: synthesis and 6-fold catalytic activity increase of sub-5 nm Pd and Pt@Pd nanocubes
Authors: Mastronardi Valentina , Kim Junseok , Veronesi Marina , Pomili Tania , Berti Francesco , Udayan Gayatri , Brescia Rosaria , Diercks Justus S. , Herranz Juan , Bandiera Tiziano , Fichthorn Kristen A. , Pompa Pier Paolo , Moglianetti Mauro
Published: June 2022

In this contribution we demonstrate the superior catalytic activity of citrate-coated sub-5 nm Pd and Pt@Pd nanocubes synthesized by harnessing the simulation-derived mechanism behind anisotropic growth.
Fabrication of multi-responsive photonic crystals based on selenium-containing copolymers
Authors: Xu Bin , Ma Xiaoliang , Dai Anqi , Pan Xiaofeng , Pan Xiangqiang , Li Na , Zhu Jian
Published: June 2022

Responsive photonic crystals (PCs) have attracted great interest due to their adjustable structure color.
Redox-neutral access to 3,3′-disubstituted oxindoles via radical coupling reactions
Authors: Lu Cong , Jing Dong , Shen Yanling , Luo Jiajing , Zheng Ke
Published: June 2022

An efficient radical protocol was developed for the assembly of valuable functional oxindoles in the absence of metals, photocatalysts, and bases.
Effect of rGO with BaCuO3 perovskite on the thermal decomposition of AP and NTO
Authors: Dave Pragnesh N. , Thakkar Riddhi , Sirach Ruksana
Published: June 2022

The thermal decomposition of AP and NTO was investigated in the presence of rGO, a perovskite structured BaCuO3 catalyst, and composite rGO + BaCuO3 using DTA analysis. These catalysts highly decreased the decomposition peak temperature of AP and NTO compared to pure AP and NTO.
Synergistic effect of reduced graphene oxide/carbon nanotube hybrid papers on cross-plane thermal and mechanical properties
Authors: Yang Yan , Shen Honglie , Yang Jiale , Gao Kai , Wang Zehui , Sun Luanhong
Published: June 2022

The top-view SEM images for (a) rGO, (b) rGO/CNT-3%, (c) rGO/CNTs-20% and the corresponding schematic diagram of photon transmission with different spacer CNTs loadings (a-i, b-ii, c-iii).
Construction and application of highly sensitive spinel nanocrystalline zinc chromite decorated multiwalled carbon nanotube modified carbon paste electrode (ZnCr2O4@MWCNTs/CPE) for electrochemical determination of alogliptin benzoate in bulk and its dosage form: green chemistry assessment
Authors: Attia Khalid A. M. , Abdel-Monem Ahmed H. , Ashmawy Ashraf M. , Eissa Amr S. , Abdel-Raoof Ahmed M.
Published: June 2022

A new sensor for alogliptin benzoate (ALG) estimation based on a simple and sensitive method was evolved on multiwalled-carbon-nanotube modified nanocrystalline zinc chromite carbon paste electrodes (ZnCr2O4@MWCNTs/CPEs).
Understanding of physicochemical properties and antioxidant activity of ovalbumin–sodium alginate composite nanoparticle-encapsulated kaempferol/tannin acid
Authors: Tao Xiaoya , Shi Hang , Cao Ailing , Cai Luyun
Published: June 2022

Ovalbumin (OVA) and sodium alginate (SA) were used as materials to prepare an OVA–SA composite carrier, which encapsulated the hydrophobic kaempferol (KAE) and the hydrophilic tannic acid (TA) (OVA–SA, OVA–TA–SA, OVA–KAE–SA, and OVA–TA–KAE–SA).
Extraction and preconcentration of Ni(ii), Pb(ii), and Cd(ii) ions using a nanocomposite of the type Fe3O4@SiO2@polypyrrole-polyaniline
Authors: Asgharinezhad Ali Akbar , Esmaeilpour Mohsen , Siavoshani Asal Yousefi
Published: June 2022

In this study, the application of Fe3O4@SiO2@polypyrrole-polyaniline magnetic nanocomposite was studied for Ni(ii), Cd(ii), and Pb(ii) ions preconcentration extraction.
N-Terminal cysteine mediated backbone-side chain cyclization for chemically enhanced phage display
Authors: Zheng Mengmeng , Haeffner Fredrik , Gao Jianmin
Published: June 2022

An NCys–Cys crosslinker elicits rapid and clean backbone-side chain cyclization, yielding nonnatural cyclic peptide libraries for phage display.
Harnessing osmotic swelling stress for robust hydrogel actuators
Authors: He Xitao , Zhu Jie , Yang Canhui
Published: June 2022

The swelling of a hydrogel can exert enormous osmotic swelling stress, which can be harnessed to achieve robust hydrogel actuators. A hydrogel jack that can lift a weight 2000 times its own weight is demonstrated.
Machine learning reveals factors that control ion mobility in anti-perovskite solid electrolytes
Authors: Kim Kwangnam , Siegel Donald J.
Published: June 2022

Machine learning is used to identify and assess the relative importance of features that control ion mobility in anti-perovskite solid electrolytes. Lattice properties such as hopping distance and channel width have the largest impact.
A dynamic nano-coordination protein hydrogel for photothermal treatment and repair of infected skin injury
Authors: Yin Weiling , Wang Qiang , Zhang Jinyi , Chen Xu , Wang Yunlong , Jiang Zhenhuan , Wang Miao , Pan Guoqing
Published: June 2022

A dynamic nano-coordination photothermal hydrogel was successfully used as a highly adaptable and antibacterial wound dressing for infected skin injuries.
K3Sr3Li2Al4B6O20F: a competitive nonlinear optical crystal for generation of a 266 nm laser
Authors: Yang Yun , Huang Shuzhao , Pan Shilie
Published: June 2022

Owing to the excellent comprehensive properties of K3Sr3Li2Al4B6O20F for practical application, especially the generation of 266 nm laser output by direct FHG, it is expected to be a promising competitive NLO crystal for generation of a 266 nm laser.
Ultrasonic investigation of the effect of compressive strains on 3D periodic bi-material structures
Authors: Chehami Lynda , Liu Jingfei , Pomarède Pascal , Lohmuller Paul , Pittrowski Boris , Meraghni Fodil , Declercq Nico F.
Published: June 2022

Due to the specific elastic properties such as high stiffness to mass ratio, regular microstructure materials are widely used in the industry. The need for nondestructive evaluation is ubiquitous to ensure material quality. As an effective nondestructive testing method, ultrasound has great potential in providing an efficient materials characterization. However, contrary to more convenient ultrasound applications, challenges arise when applying ultrasound to 3D bi-material structures due to the coexistence of different phenomena, including diffraction effects caused by the periodicity. Two linear ultrasound methods, namely the Bragg diffraction and the comb filtering effect, are proposed to address this hurdle. The results show that the comb filtering effect effectively characterizes, respectively, the vertical structural quality of the bi-material. Bragg diffraction can also expose structural variations in the horizontal plane.
The effect of glass waste as an aggregate on the compressive strength and durability of fly ash-based geopolymer mortar
Authors: Kawalu Ndapandula , Naghizadeh Abdolhossein , Mahachi Jeffrey
Published: June 2022

Geopolymers have been introduced to limit the use of ordinary Portland cement (OPC), as its production contributes to the emission of about 7% of the world’s carbon dioxide, which has a negative effect on the environment. The present study aimed to investigate the effect of glass-waste aggregate on the mechanical properties of fly ash-based geopolymer and OPC mortars. In the study, fly ash geopolymer and OPC mortar mixtures were prepared using glass-waste as fine aggregate. In addition, geopolymer and OPC mortars were also prepared using silica sand as control mixes. A blended solution comprising sodium silicate and sodium hydroxide was used as an alkali activator in fly ash geopolymer mixtures. Fresh mixtures were subjected to workability measurements, while 50 mm cubes were made for compressive strength testing. Mortar prisms of 25 x 25 x 285 mm were prepared and subjected to drying shrinkage test. From the results, the use of glass-waste aggregate negatively affected the compressive strength of the mortars, regardless of the binder type. Geopolymer mortars made using glass-waste aggregate gave 55% lower compressive strength than those made using silica sand. However, mixtures made using glass waste aggregate exhibited better performance in drying shrinkage than those made using silica sand.
Research on the production of cement composites with autonomous self-healing performance
Authors: Panfil Toader Tudor , Mircea Călin G.R. , Hegyi Andreea , Ionescu Brăduț Alexandru , Boca Anamaria , Ciascaiu Oana
Published: June 2022

In a time when the attention paid to identifying the possibilities of reducing problems due to urban pollution is increasing, the construction industry has a lot to gain if it aligns itself with the new trends of sustainable development in the field. In this context, the objective of obtaining a concrete with self-healing properties of cracks is more than appropriate, becoming a sustainable alternative for reducing the maintenance costs of transport infrastructure by increasing their operating time and by decreasing the need for the volume of repair and maintenance works, thus indirectly contributing to the reduction of environmental pollution. Preliminary results obtained using a cementitious composite with waterproofing admixture content by mass crystallization are encouraging by identifying the existence of an autonomous healing degree (closure of cracks with average opening 20-40 µm) in a proportion of at least 65% after only 96 hours of exposure in a wet-dry environment, respectively and of at least 96% after 480 hours of conditioning. The degree of novelty and value of this research is mainly due to the approach of this type of composite produced by adapting the general principles to local raw materials, including the use of specific industrial waste and by-products available in Romania (fly ash and limestone slurry).
Die Pandemie und die Online – Balintgruppe
Authors: bei Bernau
Published: June 2022

Wird professionelle Balintgruppen-Arbeit einer individuellen Psychohygiene unter
Corona- Folgen weiterhin gerecht

oder ist diese Diskussion überflüssig?1
Überlegungen zur Interaktionsbezogenen Fallarbeit (IFA) und
Balint-Arbeit in der zukünftigen Weiterbildung zum (Psychologischen)
Fachpsychotherapeuten
Authors: Grünbaum Johannes , Theilemann Steffen
Published: June 2022

Das von den Psychotherapeutenkammern der Bundesländer vorgelegte
Kompetenzprofil für (Psychologische) Psychotherapeuten1 fordert für diese die Entwicklung
ihrer Fähigkeiten zur behandlungs- und patientenbezogenen
Selbstreflexion. Der Aufbau der benannten Fähigkeiten soll nun mit Hilfe
der zukünftigen Landesweiterbildungsordnungen zum Fachpsychotherapeuten
– dabei neu die Möglichkeit zur Interaktionsbezogenen Fallarbeit
(IFA) und der Balintgruppenarbeit enthaltend – abgesichert werden. Es
werden Argumente angeführt, welcher Gewinn aus der IFA und Balintarbeit
im Vergleich zu den sonstigen Formen von Supervision und Selbsterfahrung in
einer Weiterbildung zum Fachpsychotherapeuten resultiert und welche Gefahren bei
der Implementierung der IFA und der Balintarbeit in die Weiterbildungsordnungen
bestehen.
Questionários Disability of the Arm Shoulder and Hand e Michigan Hand: Explorando a responsividade e performance diagnóstica em amostra de pacientes ambulatoriais com e sem queixas nas mãos e punho
Authors: Moraes Vinícius Ynoe de , Faria Jamile Caroline Velasques , Fernandes Marcela , Raduan-Neto Jorge , Okamura Aldo , Belloti João Carlos
Published: June 2022

Objetivo Verificar se, em uma população adulta com queixa não traumática dos membros superiores, (1) os questionários Disability of the Arm, Shoulder and Hand (DASH, na sigla em inglês) e Michigan Hand Questionnaire (MHQ, na sigla em inglês) estão suscetíveis ao “efeito de teto”, comparando com amostra de não-doentes; (2) determinar pontos de corte de performance diagnóstica e correlação interquestionários para DASH e MHQ em ambas as amostras.

Método Estudo prospectivo, comparativo e não randomizado. Incluímos 150 pacientes, 75 no grupo caso (com doença) e 75 no grupo controle (sem doença). Trata-se de amostra de pacientes recém-admitidos em ambulatório de cirurgia da mão. Os controles foram pareados de forma balanceada de acordo com a inclusão dos casos. Determinamos a presença de efeito de teto por meio da taxa de respostas máximas (> 15%) e associamos curvas receiver operating characteristic (ROC, na sigla em inglês) para a determinação de pontos de corte para a determinação de doentes, associados a medidas de sensibilidade e especificidade. Consideramos p < 0.05 para significância estatística.

Resultados Os questionários DASH e MHQ não demonstraram o efeito de teto para o grupo com doença. A porcentagem de pacientes do grupo caso com nota máxima foi de n = 18 (24%) no DASH e de 0% no MHQ. Para o grupo sem doença, 1 (1,33%) dos participantes pontuou com nota máxima para DASH, enquanto nenhum pontuou para o MHQ. Na determinação de casos, escores de DASH de 7,1 apresentam sensibilidade de 80% e especificidade de 60,3%. Para o MHQ, um escore de 76,9 apresenta sensibilidade de 56,2% e especificidade de 97,3%.

Conclusão Os questionários DASH e MHQ são ferramentas confiáveis na mensuração do impacto das morbidades das mãos e dos punhos nas atividades diárias dos pacientes e não são suscetíveis a efeito de teto. O questionário DASH é mais sensível para a identificação de doentes, enquanto o MHQ é mais específico. Em situações nas quais se espera um incremento funcional mais discreto (ou mais específico), o MHQ parece mais adequado.
Updates in the Management of Recurrent Glioblastoma Multiforme
Authors: Prajapati Hanuman Prasad , Ansari Ahmad
Published: June 2022

Background Glioblastoma is the most aggressive and diffusely infiltrative primary brain tumor. Recurrence is almost universal even after all primary standard treatments. This article aims to review the literature and update the standard treatment strategies for patients with recurrent glioblastoma.

Methods A systematic search was performed with the phrase “recurrent glioblastoma and management” as a search term in PubMed central, Medline, and Embase databases to identify all the articles published on the subject till December 2020. The review included peer-reviewed original articles, clinical trials, review articles, and keywords in title and abstract.

Results Out of 513 articles searched, 73 were included in this review after screening for eligibility. On analyzing the data, most of the studies report a median overall survival (OS) of 5.9 to 11.4 months after re-surgery and 4.7 to 7.6 months without re-surgery. Re-irradiation with stereotactic radiosurgery (SRS) and fractionated stereotactic radiotherapy (FSRT) result in a median OS of 10.2 months (range: 7.0–12 months) and 9.8 months (ranged: 7.5–11.0 months), respectively. Radiation necrosis was found in 16.6% (range: 0–24.4%) after SRS. Chemotherapeutic agents like nitrosourea (carmustine), bevacizumab, and temozolomide (TMZ) rechallenge result in a median OS in the range of 5.1 to 7.5, 6.5 to 9.2, and 5.1–13.0 months and six months progression free survival (PFS-6) in the range of 13 to 17.5%, 25 to 42.6%, and 23 to 58.3%, respectively. Use of epithelial growth factor receptor (EGFR) inhibitors results in a median OS in the range of 2.0 to 3.0 months and PFS-6 in 13%.

Conclusion Although recurrent glioblastoma remains a fatal disease with universal mortality, the literature suggests that a subset of patients may benefit from maximal treatment efforts.
Health Care Workers' Adherence to Hand Hygiene Guidelines in Emergency Surgical Room of a Tertiary Care Hospital
Authors: Dhamnaskar Suchin Sudhakar , Chaudhari Gautami Milind , Koranne Mandar Sharadchandra
Published: June 2022

Background Out of every 100 hospitalized patients, 7 patients in advanced countries and 10 patients in emerging countries acquire health care-associated infections (HCAIs). Hand hygiene (HH) procedures are the simple and cost-effective solution to significantly reduce HCAI. We wanted to know the compliance rate of HH procedures among health care workers (HCWs) working in emergency surgical room (ESR) of our institute, so that feedback can be given to them and further interventions can be planned.

Methodology This is a cross-sectional observational study conducted in ESR. Resident doctors and faculties, interns, and nurses were directly observed for all the five moments of HH recommended by World Health Organization (WHO). The data have been recorded with the WHO recommended form for observation and basic compliance calculation for HH.

Results In total, 1,370 HH opportunities were observed and recorded, of which 690 were for resident doctors and faculties, and 340 each for interns and nurses. The overall total HH compliance rate among all HCWs was 41.3% and resident doctors and faculties had the poorest compliance. Poorest compliance was observed for moment 1, whereas maximum compliance was for moment 3 among all the HCWs.

Conclusion HCWs' adherence to HH guidelines in ESR of this tertiary care hospital is low and is least in resident doctors and faculties.
The cat’s meow of experiments: how interruptions impact hearing
Authors: Piccone Ashley
Published: June 2022

Inserting an unexpected sound into streams of normal syllables degrades recall for listeners
Statistical analysis sparks new knowledge on electrical discharge in liquids
Authors: Piccone Ashley
Published: June 2022

Examining how voltage polarity, interelectrode gap distance, and electrode nature impact the stochastic discharge process
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K–specific inhibition
Authors: Baldwin Eric T. , Götte Matthias , Tchesnokov Egor P. , Arnold Eddy , Hagel Margit , Nichols Charles , Dossang Pam , Lamers Marieke , Wan Paul , Steinbacher Stefan , Romero Donna L.
Published: June 2022

Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and are derived from ancient integrations of retroviruses into the germline. The biology of HERVs is poorly defined, but there is accumulating evidence supporting pathological roles in diverse diseases, such as cancer, autoimmune, and neurodegenerative diseases. Functional proteins are produced by HERV-encoded genes, including reverse transcriptases (RTs), which could be a contributor to the pathology attributed to aberrant HERV-K expression. To facilitate the discovery and development of HERV-K RT potent and selective inhibitors, we expressed active HERV-K RT and determined the crystal structure of a ternary complex of this enzyme with a double-stranded DNA substrate. We demonstrate a range of RT inhibition with antiretroviral nucleotide analogs, while classic nonnucleoside analogs do not inhibit HERV-K RT. Detailed comparisons of HERV-K RT with other known RTs demonstrate similarities to diverse RT families and a striking similarity to the HIV-1 RT asymmetric heterodimer. Our analysis further reveals opportunities for selective HERV-K RT inhibition.
Association between elastography‐assessed muscle mechanical properties and high‐speed dynamic performance
Authors: Ema Ryoichi
Published: June 2022

Clarifying the muscular factors that contribute to performance improvement can be beneficial for athletes and coaches. The present study examined the relationships between the resting muscle shear modulus and dynamic performance during the stretch‐shortening cycle (SSC) and explosive exercises. To this end, we measured the jump height during three types of vertical jumps (squat jump [SJ], countermovement jump [CMJ], and rebound jump [RJ]) and the multi‐joint leg extension power at three velocities (low, moderate, and high) of 30 healthy women. Using ultrasound elastography, the resting shear modulus of the vastus lateralis was assessed in the sitting position as an index of passive muscle mechanical properties. The results showed that the shear modulus was positively correlated with RJ height and multi‐joint leg extension power at moderate and high velocities (r = 0.435–0.563, P < 0.05). There was no significant correlation between the shear modulus and SJ height, CMJ height, and multi‐joint leg extension power at low velocity. Contact time (i.e. the time under force exertion against the ground) during RJ (161 ± 19 ms) was 19% of that during CMJ (869 ± 171 ms). The results suggest that passive muscle mechanical properties play an important role in high‐speed SSCs and dynamic explosive performance.
Health states assessment and prediction of manufacturing system based on brittleness
Authors: Liu Weiqiang , Xu Liyun
Published: June 2022

Accurate recognition of system health states is the key to ensure the safe operation of the system. In view of the shortcomings of the existing methods, a new method of manufacturing system health states assessment and prediction based on brittleness is proposed. Firstly, according to the real-time effective performance parameters, the brittle risk entropy model of equipment is constructed, and the brittleness of corresponding equipment on each station is calculated; Secondly, based on the structural characteristics of manufacturing system, the calculation model of system brittleness is constructed by analysing from equipment to system step by step, and the mapping relationship between system brittleness and health states is established to complete the assessment of system health states; Thirdly, based on the historical data samples, the quintic polynomial regression model of system brittleness and time is constructed to predict the future health states of system and the time nodes that need to be maintained. Finally, an assembly manufacturing system is taken as an example to verify the correctness and effectiveness of the proposed method.
Preparation of AQS/GO/PVDF redox mediator membrane and the decolorization of azo dyes
Authors: Huang Y. Y. , Ye Q. , Li J. , Lan C. F. , Lin X. S.
Published: June 2022

AQS/PVDF and AQS/GO/PVDF redox mediator membranes were prepared with poly (vinylidene fluoride) (PVDF) as the raw supporting material of membrane, anthraquinone-2-sulfonic acid (AQS) as the redox mediator, and graphene oxide (GO) as an additive by an immersion precipitation method. The AQS content in the redox mediator membrane was optimized with the formation performance of AQS/PVDF membrane. With the optimal casting solution for AQS/PVDF membrane, GO was introduced as an additive to form AQS/GO/PVDF membrane. The effects of the redox mediator membranes on the bacterial decolorization of dye wastewaters were investigated. The results suggest that both AQS/PVDF and AQS/GO/PVDF membranes can promote the bacterial decolorization of dyes and the introduction of GO improves the decolorization rate more significantly because it can accelerate the electron transfer. Therefore, the conductivity of GO and the electron shuttle of AQS show a synergetic effect on accelerating the bacterial decolorization of dyes.
Q-band polarizers for the LSPE-Strip correlation radiometric instrument
Authors: Peverini O.A. , Lumia M. , Farooqui Z. , Addamo G. , Virone G. , Paonessa F. , Ciorba L. , Zannoni M. , Gervasi M. , Franceschet C. , Bersanelli M. , Mennella A. , Cuttaia F. , Morgante G. , Villa F. , Jones M.
Published: June 2022

This paper reports the design, manufacturing and testing of
the cluster of polarizers developed for the LSPE-Strip correlation
receiver array working in the Q band (39–48 GHz). Since the LSPE
experiment targets the measurement of the very faint B-mode
component of the Cosmic Microwave Background, the electromagnetic
design of the polarizers was conceived in view of minimizing the
measurement uncertainties introduced by the polarizers in the
LSPE-Strip dual-circular-polarization correlation receiving
chain. To this end, the main figures-of-merit of the LSPE-Strip
polarizers were derived in terms of the Mueller sub-matrices
relating the relevant input and output Stokes parameters. As a
result, a dual-ridge layout, in which stepped-ridge discontinuities
are interleaved with grooved cavities, was selected. The heights of
both the stepped discontinuities and the grooved cavities were
considered as design degrees of freedom in order to minimize the
differential phase-error between the two principal polarizations of
the polarizer w.r.t. the ideal 90-deg value. The latter condition
is the one required for converting the incoming circular
polarizations into two linearly polarized ones. The polarizer
design allows for a complete manufacturing route (mechanical layout,
machining process and assembling) exhibiting high accuracy
(< 10 μm) for all the units. As a consequence, the measured
performance of the whole polarizer cluster is in tight agreement
with predictions. Notably, the in-band mean value of the spurious
conversion from the total intensity I to the two linearly
polarized Stokes parameters Q and U introduced by the polarizers
is smaller than -28 dB (mean value of fifty-one polarizers) with a
standard deviation less than 1 dB.
Mechanisms driving ESM-based marine ecosystem predictive skill on the east African coast
Authors: Jeon Woojin , Park Jong-Yeon , Stock Charles A , Dunne John P , Yang Xiaosong , Rosati Anthony
Published: June 2022

The extension of seasonal to interannual prediction of the physical climate system to include the marine ecosystem has a great potential to inform marine resource management strategies. Along the east coast of Africa, recent findings suggest that skillful Earth system model (ESM)-based chlorophyll predictions may enable anticipation of fisheries fluctuations. The mechanisms underlying skillful chlorophyll predictions, however, were not identified, eroding confidence in potential adaptive management steps. This study demonstrates that skillful chlorophyll predictions up to two years in advance arise from the successful simulation of westward-propagating off-equatorial Rossby waves in the Indian ocean. Upwelling associated with these waves supplies nutrients to the surface layer for the large coastal areas by generating north- and southward propagating waves at the east African coast. Further analysis shows that the off-equatorial Rossby wave is initially excited by wind stress forcing caused by El Niño/Southern Oscillation-Indian Ocean teleconnections.
The adverse inflammatory response of tobacco smoking in COVID-19 patients: biomarkers from proteomics and metabolomics
Authors: Cui Tenglong , Miao Gan , Jin Xiaoting , Yu Haiyi , Zhang Ze , Xu Liting , Wu Yili , Qu Guangbo , Liu Guoliang , Zheng Yuxin , Jiang Guibin
Published: June 2022

Whether tobacco smoking affects the occurrence and development of coronavirus disease 2019 (COVID-19) is still a controversial issue, and potential biomarkers to predict the adverse outcomes of smoking in the progression of COVID-19 patients have not yet been elucidated. To further uncover their linkage and explore the effective biomarkers, three proteomics and metabolomics databases (i.e. smoking status, COVID-19 status, and basic information of population) from human serum proteomic and metabolomic levels were established by literature search. Bioinformatics analysis was then performed to analyze the interactions of proteins or metabolites among the above three databases and their biological effects. Potential confounding factors (age, body mass index (BMI), and gender) were controlled to improve the reliability. The obtained data indicated that smoking may increase the relative risk of conversion from non-severe to severe COVID-19 patients by inducing the dysfunctional immune response. Seven interacting proteins (C8A, LBP, FCN2, CRP, SAA1, SAA2, and VTN) were found to promote the deterioration of COVID-19 by stimulating the complement pathway and macrophage phagocytosis as well as inhibiting the associated negative regulatory pathways, which can be biomarkers to reflect and predict adverse outcomes in smoking COVID-19 patients. Three crucial pathways related to immunity and inflammation, including tryptophan, arginine, and glycerophospholipid metabolism, were considered to affect the effect of smoking on the adverse outcomes of COVID-19 patients. Our study provides novel evidence and corresponding biomarkers as potential predictors of severe disease progression in smoking COVID-19 patients, which is of great significance for preventing further deterioration in these patients.
Multiradical isogenies
Authors: Castryck Wouter , Decru Thomas
Published: June 2022

We argue that for all integers

N
≥
2

N \geq 2

and

g
≥
1

g \geq 1

there exist “multiradical” isogeny formulae, that can be iteratively applied to compute

(

N
k

,
…
,

N
k

)

(N^k, \ldots , N^k)

-isogenies between principally polarized

g
g

-dimensional abelian varieties, for any value of

k
≥
2

k \geq 2

. The formulae are complete: each iteration involves the extraction of

g
(
g
+
1
)

/

2

g(g+1)/2

different

N
N

th roots, whence the epithet multiradical, and by varying which roots are chosen one computes all

N

g
(
g
+
1
)

/

2

N^{g(g+1)/2}

extensions to an

(

N
k

,
…
,

N
k

)

(N^k, \ldots , N^k)

-isogeny of the incoming

(

N

k
−
1

,
…
,

N

k
−
1

)

(N^{k-1}, \ldots , N^{k-1})

-isogeny. Our group-theoretic argumentation is heuristic, but it is supported by concrete formulae for several prominent families. As our main application, we illustrate the use of multiradical isogenies by implementing a hash function from

(
3
,
3
)

(3,3)

-isogenies between Jacobians of superspecial genus-

2
2

curves, showing that it outperforms its

(
2
,
2
)

(2,2)

-counterpart by an asymptotic factor

≈
9

\approx 9

in terms of speed.
Minimal free resolutions of fiber products
Authors: Geller Hugh
Published: June 2022

We consider a local (or standard graded) ring

R
R

with ideals

I

′

\mathcal {I}’

,

I

\mathcal {I}

,

J

′

\mathcal {J}’

, and

J

\mathcal {J}

satisfying certain Tor-vanishing constraints. We construct free resolutions for quotient rings

R

/

⟨

I

′

,

I

J

,

J

′

⟩

R/\langle \mathcal {I}’, \mathcal {I}\mathcal {J}, \mathcal {J}’\rangle

, give conditions for the quotient to be realized as a fiber product, and give criteria for the construction to be minimal. We then specialize this result to fiber products over a field

k
k

and recover explicit formulas for Betti numbers, graded Betti numbers, and Poincaré series.
Completeness of discrete translates in the Hardy space 𝐻¹(ℝ)
Authors: Dharra Bhawna , Sivananthan S.
Published: June 2022

We provide a characterization of discrete sets

Λ
⊂

R

\Lambda \subset \mathbb {R}

that admit a function whose

Λ
\Lambda

-translates are complete in the Hardy space

H
1

(

R

)

H^1(\mathbb {R})

. In particular, we show that such a set cannot be uniformly discrete. We then give a uniformly discrete

Λ
⊂

R

\Lambda \subset \mathbb {R}

which admits a pair of functions such that their

Λ
\Lambda

-translates are complete in

H
1

(

R

)

H^1(\mathbb {R})

.
Persistence of degenerate hyperbolic lower-dimensional invariant tori in Hamiltonian systems with Bruno’s conditions
Authors: Yang Xiaomei , Xu Junxiang
Published: June 2022

This paper proves the persistence of degenerate hyperbolic lower-dimensional invariant tori in Hamiltonian systems with Bruno non-degeneracy conditions, whose frequency vector is a small dilation of the prescribed one. The proof is based on the stability of real roots of approximating real odd-order polynomials.
Positive Hermitian curvature flow on special linear groups and perfect solitons
Authors: Stanfield James
Published: June 2022

We study invariant solutions to the positive Hermitian curvature flow, introduced by Ustinovskiy, on complex Lie groups. We show in particular that the canonical scale-static metrics on the special linear groups, arising from the Killing form, are dynamically unstable. This disproves a conjecture of Ustinovskiy. We also construct certain perfect Lie groups that admit at least two distinct invariant solitons for the flow, only one of which is algebraic. This is the second known example of a geometric flow with non-algebraic, homogeneous solitons. The first being the G2-Laplacian flow.
On the global behavior of linear flows
Authors: Colonius Fritz
Published: June 2022

For linear flows on vector bundles, it is analyzed when subbundles in the Selgrade decomposition yield chain transitive subsets for the induced flow on the associated Poincaré sphere bundle.