bluuebunny/crossref_metadata_2025 huggingface dataset:
Developmental dynamics of two bipotent thymic epithelial progenitor types
Authors: Nusser Anja , Sagar  , Swann Jeremy B. , Krauth Brigitte , Diekhoff Dagmar , Calderon Lesly , Happe Christiane , Grün Dominic , Boehm Thomas
Published: May 2022

T cell development in the thymus is essential for cellular immunity and depends on the organotypic thymic epithelial microenvironment. In comparison with other organs, the size and cellular composition of the thymus are unusually dynamic, as exemplified by rapid growth and high T cell output during early stages of development, followed by a gradual loss of functional thymic epithelial cells and diminished naive T cell production with age1–10. Single-cell RNA sequencing (scRNA-seq) has uncovered an unexpected heterogeneity of cell types in the thymic epithelium of young and aged adult mice11–18; however, the identities and developmental dynamics of putative pre- and postnatal epithelial progenitors have remained unresolved1,12,16,17,19–27. Here we combine scRNA-seq and a new CRISPR–Cas9-based cellular barcoding system in mice to determine qualitative and quantitative changes in the thymic epithelium over time. This dual approach enabled us to identify two principal progenitor populations: an early bipotent progenitor type biased towards cortical epithelium and a postnatal bipotent progenitor population biased towards medullary epithelium. We further demonstrate that continuous autocrine provision of Fgf7 leads to sustained expansion of thymic microenvironments without exhausting the epithelial progenitor pools, suggesting a strategy to modulate the extent of thymopoietic activity.
Novel electrochemical PMI marker biosensor based on quantum dot dissolution using a double-label strategy
Authors: Jeong Bongjin , Akter Rashida , Oh Jeonghyun , Lee Dong-Gi , Ahn Chang-Geun , Choi Jong-Soon , Rahman Md. Aminur
Published: May 2022

A novel and facile post-mortem interval (PMI) biosensor was fabricated using a double-label strategy to detect the glyceraldehyde 3-phosphate dehydrogenase (GAPDH) biomarker. A monoclonal anti-GAPDH antibody was immobilized on a surface label containing cadmium selenide quantum dots (CdSe QDs) on a cysteamine graphene oxide (Cys-GO) self-assembled monolayer. Glucose oxidase (GOx) was used as a signal label to conjugate with GAPDH. GAPDH recognition was achieved through the dissolution of the surface-attached CdSe QDs by hydrogen peroxide generated through GAPDH-conjugated GOx-catalyzed β-glucose oxidation. To enhance sensitivity, a competitive interaction was introduced between free and conjugated GAPDH to the active site of the anti-GAPDH antibody. The electrochemical response due to CdSe dissolution decreased proportionally with the concentration of free GAPDH. Differential pulsed voltammetry was conducted to determine the analytical characteristics of the immunosensor, including the limit of detection, linear dynamic range, target selectivity, system stability, and applicability toward the analysis of real samples.
Application of Box-Behnken design for optimization of phenolics extraction from Leontodon hispidulus in relation to its antioxidant, anti-inflammatory and cytotoxic activities
Authors: Abd-El-Aziz Noha Mokhtar , Hifnawy Mohamed S. , El-Ashmawy Ahmed A. , Lotfy Rehab A. , Younis Inas Y.
Published: May 2022

To the best of our knowledge, there have been no phytochemical studies concerning the wild plant Leontodon hispidulus Boiss. (Asteraceae). Optimization of the green extraction process of the plant aerial parts, identification of main phenolic compounds, evaluation of antioxidant, anti-inflammatory and anticancer activities of the optimized extract have been carried out. HPLC-analysis was performed using 95% ethanolic extract. 3-Level Box-Behnken Design was applied for optimization of extraction yield and total phenolic content using 3-factors (ethanol/water ratio, material/solvent ratio and extraction time). Antioxidant, anticancer and anti-inflammatory activities were evaluated by ABTS-assay, prostate and cervical carcinoma human cell lines and carrageenan-induced rat paw edema model, respectively. HPLC-analysis showed the presence of quercetin, rutin, kaempferol, chlorogenic and ρ-coumaric acids. Increasing both ethanol/water ratio and material/solvent ratio decreased the yield, while, it increased by prolongation of the extraction time. High material/solvent ratio increased the phenolic content. The optimized extract showed high total phenolic content (104.18 µg/mg) using 201 ml of 74.5% ethanol/water at 72 h and good biological activities. Antioxidant activity was found to be 41.89 mg Trolox-equivalent/gm, with 80% free radicals inhibition. For anti-inflammatory activity, 100 mg/kg of the extract inhibited the edema in rats by 83.5% after 4 h of carrageenan injection as compared to 81.7% inhibition by indomethacin. Prostate carcinoma cell line was more sensitive to the anticancer activity of the extract than cervical carcinoma cell line (IC50 = 16.5 and 23 μg/ml, respectively). The developed extraction procedure proved to be efficient in enriching the extract with phenolic compounds with promising anticancer, anti-inflammatory and antioxidant activities.
The relationships between physical activity, lumbar multifidus muscle morphology, and low back pain from childhood to early adulthood: a 12-year longitudinal study
Authors: Cunningham Erin , Wedderkopp Niels , Kjaer Per , Beynon Amber , Noble Jeremy , Hebert Jeffrey J.
Published: May 2022

We investigated the longitudinal associations between physical activity (PA), lumbar multifidus morphology, and impactful low back pain (LBP) in young people. Nine-year-old children were recruited from 25 primary schools and followed up at age 13, 16, and 21 years. We measured PA with accelerometers at age 9, 13, and 16; quantified patterns of lumbar multifidus intramuscular adipose tissue (IMAT) change from 13 to 16 years using magnetic resonance imaging; and recorded LBP and its impact with standardised questionnaires and interviews. Associations were examined with crude and adjusted logistic or multinomial models and reported with odds ratios (OR) or relative risk ratios (RRR). We included data from 364 children (mean[SD] age = 9.7[.4] years). PA behaviour was not associated with LBP. Having persistently high IMAT levels at age 13 and 16 was associated with greater odds of LBP (OR[95% CI] = 2.98[1.17 to 7.58]). Increased time in moderate and vigorous intensity PA was associated with a lower risk of higher IMAT patterns (RRR[95% CI] = .67[.46 to .96] to .74[.55 to 1.00]). All associations became non-significant after adjusting for sex and body mass index (BMI). Future studies investigating the relationships between PA behaviour, lumbar multifidus IMAT, and impactful LBP should account for potential confounding by sex and BMI.
Impact of the revised definition on incidence and outcomes of acute exacerbation of idiopathic pulmonary fibrosis
Authors: Yoo Jung-Wan , Kim Jehun , Song Jin Woo
Published: May 2022

The revised definition of acute exacerbation (AE) in idiopathic pulmonary fibrosis (IPF) was proposed in 2016, but changes in the incidence and impact on prognosis of the re-defined AE compared to those of the previous definition remain unclear. Clinical data of 445 patients with IPF (biopsy proven cases: 165) were retrospectively reviewed. The median follow-up period was 36.8 months and 17.5% (n = 78) experienced AE more than once. The 1- and 3-year incidence rates of AE were 6.7% and 16.6%, respectively, and idiopathic AE accounted for 82.1% of AE. Older age, lower diffusing capacity of the lung for carbon monoxide and 10% relative decline in forced vital capacity for 6 months were independently associated with AE. The in-hospital mortality rate following AE was 29.5%. In the multivariable analysis, AE was independently associated with poor prognosis in patients with IPF. Compared to the old definition, the revised definition relatively increased the incidence of AE by 20.4% and decreased the in-hospital mortality by 10.1%. Our results suggest that the revised definition affects approximately 20% increase in the incidences and 10% reduction in the in-hospital mortality of AE defined by the past definition.
Evaluating the performance characteristics of five lateral flow assays for the detection of the SARS-CoV-2 nucleocapsid antigen
Authors: Heskin J. , Pallett S. J. C. , Al-Hindawi A. , Davies G. W. , Rayment M. , Mughal N. , Randell P. , Jones R. , Moore L. S. P.
Published: May 2022

In response to the COVID-19 pandemic, lateral flow assays (LFAs) for the detection of SARS-CoV-2 antigen have been proposed as a complementary option to the more costly and time consuming reverse-transcriptase polymerase chain reaction (RT-PCR). We assessed five commercially available SARS-CoV-2 antigen detecting LFAs (ASSUT EUROPE (Rome, Italy), Besthree (Taizhou, China), Encode (Zhuhai, China), Fortress (Antrim UK), and Hughes Medical (Buckinghamshire, UK), using samples collected from hospitalised individuals with COVID-19 and compared these results against established RT-PCR assays with the aim of estimating test performance characteristics. We performed a diagnostic accuracy study of the five LFAs on 110 inpatients with confirmed COVID-19 and 75 COVID-19 negative control participants. Assay evaluation was performed using a modified version of each manufacturer’s protocol allowing for parallel testing of a single sample on multiple assays. Additional variables were studied including infection acquisition, oxygenation requirements at time of swabbing, and patient outcomes. The 110 patients were 48% (53) female, with mean age 67 years (range 26–100 years), and 77% (85) cases were community onset SARS-CoV-2. Across the five assays, sensitivity ranged from 64 (95% CI 53–73) to 76% (95% CI 65–85); Fortress performed best with sensitivity of 76% (95% CI 65–85). Specificity was high across all assays with 4/5 LFAs achieving 100%. LFA sensitivity was not dependant on RT-PCR cycle thresholds. SARS-CoV-2 antigen detecting LFAs may complement RT-PCR testing to facilitate early diagnosis and provide community testing strategies for identification of patients with COVID-19, however we find suboptimal test performance characteristics across a range of commercially available manufacturers, below WHO and MHRA pre-set sensitivity performance thresholds. With such variation in sensitivity between LFAs and PCR testing and between assay brands, we advise caution in the deployment of LFAs outside of environments with clinical oversight.
Simultaneous amplification of multiple immunofluorescence signals via cyclic staining of target molecules using mutually cross-adsorbed antibodies
Authors: Yeon Haemin , Cho Yehlin , Seo Junyoung , Sim Yeonbo , Chang Jae-Byum
Published: May 2022

Amplification of immunofluorescence (IF) signals is becoming increasingly critical in cancer research and neuroscience. Recently, we put forward a new signal amplification technique, which we termed fluorescent signal amplification via cyclic staining of target molecules (FRACTAL). FRACTAL amplifies IF signals by repeatedly labeling target proteins with a pair of secondary antibodies that bind to each other. However, simultaneous amplification of multiple IF signals via FRACTAL has not yet been demonstrated because of cross-reactivity between the secondary antibodies. In this study, we show that mutual cross-adsorption between antibodies can eliminate all forms of cross-reactions between them, enabling simultaneous amplification of multiple IF signals. First, we show that a typical cross-adsorption process—in which an antibody binds to proteins with potential cross-reactivity with the antibody—cannot eliminate cross-reactions between antibodies in FRACTAL. Next, we show that all secondary antibodies used in FRACTAL need to be mutually cross-adsorbed to eliminate all forms of cross-reactivity, and then we demonstrate simultaneous amplification of multiple IF signals using these antibodies. Finally, we show that multiplexed FRACTAL can be applied to expansion microscopy to achieve higher fluorescence intensities after expansion. Multiplexed FRACTAL is a highly versatile tool for standard laboratories, as it amplifies multiple IF signals without the need for custom antibodies.
Viral communities in the parasite Varroa destructor and in colonies of their honey bee host (Apis mellifera) in New Zealand
Authors: Lester Philip J. , Felden Antoine , Baty James W. , Bulgarella Mariana , Haywood John , Mortensen Ashley N. , Remnant Emily J. , Smeele Zoe E.
Published: May 2022

The parasitic mite Varroa destructor is a leading cause of mortality for Western honey bee (Apis mellifera) colonies around the globe. We sought to confirm the presence and likely introduction of only one V. destructor haplotype in New Zealand, and describe the viral community within both V. destructor mites and the bees that they parasitise. A 1232 bp fragment from mitochondrial gene regions suggests the likely introduction of only one V. destructor haplotype to New Zealand. Seventeen viruses were found in bees. The most prevalent and abundant was the Deformed wing virus A (DWV-A) strain, which explained 95.0% of the variation in the viral community of bees. Black queen cell virus, Sacbrood virus, and Varroa destructor virus 2 (VDV-2) played secondary roles. DWV-B and the Israeli acute paralysis virus appeared absent from New Zealand. Ten viruses were observed in V. destructor, with > 99.9% of viral reads from DWV-A and VDV-2. Substantially more variation in viral loads was observed in bees compared to mites. Where high levels of VDV-2 occurred in mites, reduced DWV-A occurred in both the mites and the bees co-occurring within the same hive. Where there were high loads of DWV-A in mites, there were typically high viral loads in bees.
Chronic treatment with serelaxin mitigates adverse remodeling in a murine model of ischemic heart failure and modulates bioactive sphingolipid signaling
Authors: Devarakonda Teja , Valle Raleigh Juan , Mauro Adolfo G. , Lambert Johana M. , Cowart Lauren Ashley , Salloum Fadi N.
Published: May 2022

Relaxin is a pleiotropic hormone demonstrated to confer cardioprotection in animal models of myocardial infarction and ischemic heart failure by modulating inflammation, fibrosis and arrhythmogenesis. Several of these pathways in the ischemic myocardium are intricately tied with the downstream signaling of bioactive sphingolipids, which play an active role during post-infarction remodeling. In this current study, we examined the effects of relaxin on sphingosine 1-phosphate (S1P), and the potential benefits of relaxin treatment on cardiac health in a rodent model of ischemic heart failure. Acute (30 min) and sub-acute (24 h) treatment of primary cardiomyocytes with serelaxin (recombinant human relaxin-2) increased the cardiomyocyte content of S1P. In the rodent model, treatment with relaxin for 28 days following myocardial ischemia by way of permanent left coronary artery occlusion improved survival and cardiac function, reduced fibrosis and apoptosis, and mitigated the expression of several pro-inflammatory and pro-fibrotic markers. The expression of beclin-1 (autophagy marker) was also reduced. The expression of S1P was significantly higher in cardiac tissue and plasma samples extracted from serelaxin-treated mice at day 28. In conclusion, our studies show a significant protection from relaxin in ischemic heart disease, and demonstrate the association between relaxin signaling and S1P generation.
Unraveling the reasons behind lead phthalocyanine acting as a good absorber for near-infrared sensitive devices
Authors: Kato Masahiro , Yoshizawa Hayato , Nakaya Masato , Kitagawa Yasutaka , Okamoto Koichi , Yamada Tomoaki , Yoshino Masahito , Tanaka Kentaro , Onoe Jun
Published: May 2022

Lead phthalocyanine (PbPc) is well known to be used as a good near-infrared (NIR) light absorber for organic solar cells (OSCs) and photodetectors. The monoclinic and triclinic phases have been understood to absorb the visible and NIR regions, respectively, so far. In the present study, we demonstrated from the absorption spectra and theoretical analysis that the visible band considerably originates from not only the monoclinic but also the amorphous and triclinic phases, and revealed the exciton dynamics in the PbPc film from static/time-resolved photoluminescence (PL), which are first reported. By comparing the external quantum efficiency between PbPc- and ZnPc-based OSCs in relation to their structure, morphology, and optical (absorption and PL) characteristics, we unraveled the reasons behind the PbPc film used as a good absorber for NIR-sensitive devices.
Physical and electrophysiological motor unit characteristics are revealed with simultaneous high-density electromyography and ultrafast ultrasound imaging
Authors: Carbonaro Marco , Meiburger Kristen M. , Seoni Silvia , Hodson-Tole Emma F. , Vieira Taian , Botter Alberto
Published: May 2022

Electromyography and ultrasonography provide complementary information about electrophysiological and physical (i.e. anatomical and mechanical) muscle properties. In this study, we propose a method to assess the electrical and physical properties of single motor units (MUs) by combining High-Density surface Electromyography (HDsEMG) and ultrafast ultrasonography (US). Individual MU firings extracted from HDsEMG were used to identify the corresponding region of muscle tissue displacement in US videos. The time evolution of the tissue velocity in the identified region was regarded as the MU tissue displacement velocity. The method was tested in simulated conditions and applied to experimental signals to study the local association between the amplitude distribution of single MU action potentials and the identified displacement area. We were able to identify the location of simulated MUs in the muscle cross-section within a 2 mm error and to reconstruct the simulated MU displacement velocity (cc > 0.85). Multiple regression analysis of 180 experimental MUs detected during isometric contractions of the biceps brachii revealed a significant association between the identified location of MU displacement areas and the centroid of the EMG amplitude distribution. The proposed approach has the potential to enable non-invasive assessment of the electrical, anatomical, and mechanical properties of single MUs in voluntary contractions.
Mulching impact of Jatropha curcas L. leaves on soil fertility and yield of wheat under water stress
Authors: Irshad Muhammad , Ullah Faizan , Mehmood Sultan , Al-Huqail Asma A. , Fahad Shah , Siddiqui Manzer H. , Ali Hayssam M. , Saud Shah , Danish Subhan , Datta Rahul , Dawar Khadim
Published: May 2022

In present studies we have evaluated mulching impact ofJatropha curcasleaves on soil health and yield of two wheat (Triticum aestivumL.) varieties Wadan-2017 (rainfed) and Pirsabak-2013 (irrigated) under imposed water stress. Mulch of Jatropha leaves was spread on the soil surface at the rate of 0, 1, 3 and 5 Mg ha−1after seed germination of wheat. Water stress was imposed by skipping irrigations for one month at anthesis stage of wheat maintaining 40% soil field capacity. We found a significant decline in soil microbial biomass carbon (30.27%), total nitrogen (22.28%) and organic matter content (21.73%) due to imposed water stress in non-mulch plots. However, mulch application at 5 Mg ha−1significantly improved soil organic matter (38.18%), total nitrogen (37.75%), phenolics content (16.95 mg gallic acid equivalents/g) and soil microbial biomass carbon (26.66%) as compared to non-mulch control. Soil health indicators like soil carbonates, bicarbonates, electrical conductivity, chloride ions and total dissolved salts were decreased by 5 Mg ha−1mulch application. We noted a decline in yield indicators like spike weight (14.74%), grain spike−1(7.02%), grain length (3.79%), grain width (3.16%), 1000 grains weight (6.10%), Awn length (9.21%), straw weight (23.53%) and total grain yield (5.98%) of wheat due to imposed water stress. Reduction in yield traits of wheat due to water stress was higher in Pirsabak-2013 than Wadan-2017. Jatropha leaves mulch application at 5 Mg ha−1significantly minimized the loss in yield traits of wheat crop caused by water stress.Jatropha curcasleaves mulch application at 5 Mg ha−1is recommended for the successful establishment of wheat crop under water deficit conditions.
Identification and validation of a novel pyroptosis-related lncRNAs signature associated with prognosis and immune regulation of hepatocellular carcinoma
Authors: Zhang Zeyu , Xia Fada , Xu Zhijie , Peng Jinwu , Kang Fanhua , Li Jianbo , Zhang Wenqin , Hong Qianhui
Published: May 2022

Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes. However, research concerning pyroptosis-related lncRNAs in hepatocellular carcinoma (HCC) remains scarce. This study aims to explore the prognostic pyroptosis-related long non-coding RNAs (lncRNAs) of HCC patients. Data of 373 HCC patients were obtained from the TCGA database. The entire cohort was randomly divided into a training cohort and a validation cohort in a 2:1 ratio. Pyroptosis-related lncRNAs were identified by the Pearson correlation analysis with reported pyroptosis-related genes. LASSO Cox regression was used to construct the signature. A prognostic signature consisting of nine pyroptosis-related lncRNAs was identified, and patients with lower risk scores had a better prognosis than those with higher risk scores. Multivariate Cox regression analysis showed that the signature was an independent risk factor for prognosis in both the training and validation cohorts. In the training cohort, the area under the signature curve reached 0.8043 at 1-year, 0.7878 at 2-year, and 0.8118 at 3-year; in the validation cohort, it reached 0.7315 at 1-year, 0.7372 at 2-year, and 0.7222 at 3-year. Gene set enrichment analysis (GSEA) suggested associations between the signature and several immune-related pathways. The expression of multiple immune checkpoints was also increased in the high-risk group, including PD-1, PD-L1, CTLA4, B7-H3, VSIR, LAG3, and TIGIT. A novel pyroptosis-related lncRNA signature, which may be associated with tumor immunity and potentially serve as an indicator for immunotherapy, has been identified to precisely predict the prognosis of HCC patients.
Recent advances in the synthesis of thienoindole analogs and their diverse applications
Authors: Pandey Shubham , Aggarwal Simran , Choudhary Ritu , Awasthi Satish K.
Published: May 2022

Synthesis of thienoindolesviaeasy and atom economical approaches followed by their potent applications.
Red aqueous room-temperature phosphorescence modulated by anion–π and intermolecular electronic coupling interactions
Authors: Liu Fengbo , Yang Hai , Sun Dongdong , Gao Fang , Zhang Xiongzhi , Zhao Zhiyong , Han Xie , Liu Simin
Published: May 2022

The aqueous room temperature phosphorescence of 2Br–NDI is modulated by long-lived-emitting anion–π interactions and tremendously enhanced by intermolecular electronic coupling interactions with the ISC-boosting carbonyl rims of CB[8] host.
A rare monoclonal antibody discovery based on indirect competitive screening of a single hapten-specific rabbit antibody secreting cell
Authors: Li Yuan , Li Peipei , Ke Yuebin , Yu Xuezhi , Yu Wenbo , Wen Kai , Shen Jianzhong , Wang Zhanhui
Published: May 2022

A rare antibody that is able to tolerate physio-chemical factors is preferred and highly demanded in diagnosis and therapy.
Protein scaffolds: antibody alternatives for cancer diagnosis and therapy
Authors: Luo Renli , Liu Hongguang , Cheng Zhen
Published: May 2022

Although antibodies are well developed and widely used in cancer therapy and diagnostic fields, some defects remain, such as poor tissue penetration, long in vivo metabolic retention, potential cytotoxicity, patent limitation, and high production cost.
Electron paramagnetic resonance spectroscopy and first-principles calculations of Cr3+ doped KDP crystals
Authors: Wei Liening , Li Yang , Jiang Xuanyu , Wu Pengcheng , Zhao Xian , Zhang Lisong , Liu Baoan , Chai Xiangxu , Xu Mingxia , Sun Xun , Hong Wei
Published: May 2022

The behavior of the Cr3+ centers in KDP:(CrNO3)3 crystals is illustrated by an analysis of experimental and theoretical calculations.
Topological bands in the PdSe2 pentagonal monolayer
Authors: Bravo Sergio , Pacheco M. , Correa J. D. , Chico Leonor
Published: May 2022

The electronic structure of monolayer pentagonal palladium diselenide (PdSe2) is analyzed from the topological band theory perspective.
Promotional effect of Fe and Ce co-doping on a V2O5–WO3/TiO2 catalyst for SCR of NOx with high K and Pb resistance
Authors: Yi Xianfang , Wang Jinxiu , Liu Yuqiu , Chen Yanting , Chen Jinsheng
Published: May 2022

The cooperation of Fe and Ce on V2O5–WO3/TiO2 improves the K and Pb resistance by promoting the redox and NOx adsorption ability.
Epigoitrin alleviates lipid and glucose metabolic disorders induced by a high-fat diet
Authors: Li Mingming , Xiao Yang , Xiao Lianggui , Li Yu , Jia Mengting , Sun Yu , Pan Tingli , Zhou Lei , Li Yixing
Published: May 2022

Epigoitrin, extracted from Radix isatidis, had excellent lipid-lowering effects.
Bioactives and functional food ingredients with promising potential for the management of cerebral and myocardial ischemia: a comprehensive mechanistic review
Authors: Zahran Eman Maher , Sayed Ahmed M. , Alaaeldin Rania , Elrehany Mahmoud A. , Khattab Amira R. , Abdelmohsen Usama Ramadan
Published: May 2022

Ischemia is a deadly disease with complex pathophysiology and has a limited number of drugs. A compilation of the mechanistic studies of food bioactives with multimodal actions and higher safety has been provided in this review.
Pre-illness data reveals differences in multiple metabolites and metabolic pathways in those who do and do not recover from infectious mononucleosis
Authors: Jason Leonard A. , Conroy Karl E. , Furst Jacob , Vasan Karthik , Katz Ben Z.
Published: May 2022

Metabolic pathways related to energy production, amino acids, nucleotides, nitrogen, lipids, and neurotransmitters in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may contribute to the pathophysiology of ME/CFS.
Facile construction of the all-bridge-position-functionalized 2,4,6,8-tetraazaadamantane skeleton and conversion of its N-functionalities
Authors: Cai Rongbin , Zhou Qi , Hou Tianjiao , Li Bing , Liu Yunzhi , Li Huan , Gao Yuan , Zhu Longyi , Luo Jun
Published: May 2022

An unusual protocol of a “one-pot” three-step strategy to build the 2,4,6,8-tetraazaadamantane skeleton was developed. 17 products were obtained in 19–46% yields, and the N-benzyl groups were transferred to nitroso, acetyl, benzoyl and nitro groups.
High-performance ferroelectric nonvolatile memory based on Gd-and Ni-codoped BiFeO3 films
Authors: Song Yanling , Wu Qiyuan , Jia Caihong , Gao Zhaomeng , Zhang Weifeng
Published: May 2022

(Gd, Ni) codoped BiFeO3 (BGFNO) film exhibits robust ferroelectricity, which leads to excellent resistive switching behavior.
Enhancing the physical properties and photocatalytic activity of TiO2 nanoparticles via cobalt doping
Authors: Safeen Akif , Safeen Kashif , Ullah Rehan , Zulfqar  , Shah Wiqar H. , Zaman Quaid , Althubeiti Khaled , Al Otaibi Sattam , Rahman Nasir , Iqbal Shahid , Khan Alamzeb , Khan Aurangzeb , Khan Rajwali
Published: May 2022

(a) dielectric constant, (b) dielectric loss and (c) AC conductivity vs. frequency for un-doped and 5 at% Co-doped TiO2 NPs.
Synergistic melamine intercalation and Zn(NO3)2 activation of N-doped porous carbon supported Fe/Fe3O4 for efficient electrocatalytic oxygen reduction
Authors: Ni Yaoyao , Wang Tingjuan , Zhou Yan , Wang Chao , Tang Yingwen , Li Tao , Geng Baoyou
Published: May 2022

N-doped 2D porous carbon supported Fe/Fe3O4 composite is fabricated by melamine intercalation and zinc nitrate as activator. The synergistic effect makes the catalyst shows excellent ORR activity and decent durability compared with commercial Pt/C.
High-performance self-supporting AgCoPO4/CFP for hydrogen evolution reaction under alkaline conditions
Authors: Zhao Wan , Cao Hongshuai , Ruan Liting , He Shaoying , Xu Zhiai , Zhang Wen
Published: May 2022

The synthesis of AgCoPO4/CFP for high performance hydrogen evolution reaction in an alkaline environment.
Design and parametric optimization of ion-implanted PERC solar cells to achieve 22.8% efficiency: a process and device simulation study
Authors: Kashyap Savita , Madan Jaya , Pandey Rahul
Published: May 2022

22.8% efficient ion-implanted PERC solar cells are designed using industry-standard process/device simulators. The collective impact of ion implantation dose and energy on PV parameters have been investigated to optimize emitter region performance.
Effect of water and DMSO on mechanoelectrical conversion of Schottky DC generators
Authors: Ding Xiang , Shao Hao , Wang Hongxia , Bai Ruixi , Fang Jian , Lin Tong
Published: May 2022

The water content in polypyrrole profoundly affects the electrical output of polypyrrole-based Schottky DC generators, and adding DMSO to polypyrrole enhances the device energy conversion performance.
Theoretical design principles of metal catalysts for selective ammonia oxidation from high throughput computation
Authors: Yang Jiaqiang , Chen Xi , Liu Zhang , Wang Qingbo , Wen Yanwei , Zhang Aimin , Chen Rong , Shan Bin
Published: May 2022

High throughput calculation is performed to reveal the ruling laws of catalytic performance and further screen potential alloy catalysts with high activity and selectivity for selective catalytic oxidation of ammonia (NH3-SCO).
Uniaxially oriented FAxMA1−xPbI3 films with low intragrain and structural defects for self-powered photodetectors
Authors: Zhang Li , Zhang Teng , Gao Yaping , Cui Deliang , Wang Qilong , Lian Gang , Yu Haohai , Zhang Huaijin , Wong Ching-Ping
Published: May 2022

A synergetic effect of composition engineering and crystal engineering is proposed to grow uniaxially oriented FAxMA1−xPbI3 films with low intragrain and structural defects, which exhibit a superior self-powered photoresponse.
Cu substitution boosts self-trapped exciton emission in zinc-based metal halides for sky-blue light-emitting diodes
Authors: Ren Miao , Zhang Shuai , Chang Tong , Yao Jiandong , Gao Yilin , Yuan Mingjian , Cao Sheng , Zhao Jialong , Zou Bingsuo , Zeng Ruosheng
Published: May 2022

The PLQY of Cu:(PEA)2ZnX4 metal halides was greatly boosted after Cu substitution and photophysical mechanisms are revealed. Further, Cu:(PEA)2ZnX4 was used as the active layer and sky-blue light-emitting diodes were prepared for the first time.
A π-orbital model to study substituent effects in organic room-temperature phosphorescent materials
Authors: Gong Wenqi , Qin Ke , Yao Xiaokang , Li Qiuying , Lv Anqi , Ye Wenpeng , Shi Huifang , An Zhongfu , Ma Huili
Published: May 2022

A π-orbital model, converting (n, π*) to (π, π*) by raising the π-orbital energy level, was built to reveal the changes in room-temperature phosphorescence (RTP) efficiency and lifetime of organic materials caused by electron-donating groups (EDGs).
Access to Speech and Language Services and Service Providers for Children With Speech and Language Disorders
Authors: Davidson Meghan M. , Alonzo Crystle N. , Stransky Michelle L.
Published: May 2022

Objectives:

The purposes of this study were to (a) examine children's access to services for their speech and language disorders during their lifetimes; (b) identify any child, disorder, and family characteristics associated with access to services; and (c) describe the speech and language service providers among children who received care.

Study design:

Data from the 2012 National Health Interview Survey were used for this retrospective cohort study. Our sample included 491 children (ages 3;0–17;11 [years;months]) with speech disorders and 333 children with language disorders. We measured the receipt of services for speech or language difficulties (main outcome) and the type of professional providing services (secondary outcome). We examined associations between services and child, disorder, and family characteristics.

Results:

Approximately 75% of children with speech and language disorders had ever received services for their difficulties. Privately insured children and children with co-occurring conditions were more likely to receive services than their peers who were uninsured (speech: 6.1 [1.7,21.3]; language: 6.6 [1.3,32.9]) and had no co-occurring conditions (speech: 2.1 [1.2,3.9]; language: 2.9 [1.5,5.5]). Speech-language pathologists (SLPs) were the most commonly reported provider of services (speech: 68%, language: 60%) followed by early interventionists.

Conclusions:

Most children with speech and language disorders received services. However, disparities existed by race/ethnicity, health insurance type, co-occurring diagnoses, and disorder duration (speech only). Most children who received services were being provided with care by the experts of speech and language: SLPs. Updated population-based data and implementation studies are needed to document speech and language screening, referral, and access to services.

Supplemental Material:

https://doi.org/10.23641/asha.19799389
Comparative study of solar tracking and fixed-tilt photovoltaic modules in Morocco
Authors: Mrhar Oumaima , Kandoussi Khalid , Eljouad Mohamed , Sellami Assia
Published: May 2022

Nowadays the global energy context is being difficult, looking for other alternatives is obviously observed in many countries, and the expectations in terms of renewable energies are increase continuously. Taking the example of photovoltaic energy with its environmental advantages and especially the fixed-tilt solar panel. This technology is used to optimize radiation received, and more the surface of a solar panel is perpendicular to incident rays, more the efficiency is better, hence the objective of our work. In this context, a comparative study between a fixed-tilt panel and a panel with a 2-axis Open Loop tracking system is performed for the first time in AFRICA, and exactly in the 6 regions of MOROCCO distributed according to their solar potential. The comparative study is done on Matlab/Simulink software, in which the incident radiation for both systems is calculated from a radiation model based on zenith and azimuth angles obtained via the Solar position algorithm; the photovoltaic power is also calculated in our program. As a results, we found that the use of open-loop solar tracking systems in less sunny areas and periods increase the productivity of photovoltaic panels and consequently improves its energy efficiency.
Application of Modern Information Technology in College Physical Education
Authors: Jin Zhixiang , Zou Wei
Published: May 2022

In the face of the reality of the work of traditional college physical education personnel, through the integration of modern information technology, not only helps the return of the value of sports aesthetics, but also helps students to participate in the process of sports practice, the profound perception of sports aesthetics in physical education helps students to form a comprehensive understanding of the value of multiple education in physical education. Based on this, in the intelligent education environment, based on modern information technology, innovation and reconstruction of college sports education mechanism, to truly achieve the goal of college sports education. This paper analyzes the background and main points of the application of modern information technology in college physical education, and puts forward the application strategies.
Research on Multi-interactive Teaching of College English under the Environment of Information Technology
Authors: Zheng Qiongjing
Published: May 2022

Multi-interactive teaching model is an important way to improve the quality of college English teaching, and it is also the key foundation to improve students' understanding of college English teaching content. In the increasingly mature environment of information technology application, students' learning enthusiasm will be fully stimulated, multi-interactive communication will be deepened, and students' English core literacy will be effectively enhanced by giving full play to the advantages of information technology, to upgrade the intelligence of college English teaching system. Based on the analysis of the multi-interactive teaching mode of college English under the information technology environment, this paper puts forward some practical strategies for innovating the multi-interactive teaching of college English by using information technology.
Study on the Comprehensive Management Mode of Diabetic Patients under the Mode of Medical Care Combined with Old-age Care
Authors: Xing Xiaodong , Wang Wenyan
Published: May 2022

Diabetes is a chronic disease with a high incidence rate. In the context of health care in China, an intelligent monitoring system combining medical care with old-age care has been established based on the service model of combining medical care with old-age care, in view of the reality of diabetes patients, while accurately and effectively identifying the nursing problems of patients with diabetes, a scientific and reasonable individualized nursing plan will be formulated, and the relatively limited nursing resources will be fully utilized, to improve the quality of nursing care for the aged with diabetes mellitus. Based on the model of medical care combined with old-age care, combined with diabetes patients, a comprehensive management model was put forward.
Research on interactive innovation of computer-aided music teaching
Authors: Wang Jing , Deng Xiaolong
Published: May 2022

Music education is an important subject that deepens five education and promotes students' art accomplishment and humanity cultivation in an all-round way, which is of great practical value to improve students' comprehensive quality. In the context of wisdom education, it will provide strong support for students to participate in music teaching deeply by giving full play to the advantages of computer-aided instruction and building an interactive platform for music teaching. By studying the value of interactive innovation in computer-aided music teaching, this paper puts forward the interactive innovation strategy of computer-aided music teaching.
Research on Intrusion Detection Based on User Portrait Technology
Authors: Wang Zhenduo
Published: May 2022

Under the big data scene, the intrusion detection technology has some problems, such as weak data processing ability, difficulty of precise location and so on. The intrusion detection technology based on user portrait technology, on the basis of fully mining the practical value of big data technology, refines the detection granularity, improves the intelligent and accurate characteristics of intrusion detection. The experimental results show that the intrusion detection model based on user portrait can detect abnormal users quickly and accurately, and improve the effect of intrusion detection, and has good practical value.
Research on the Application of Ant Colony Algorithm in University Teaching Management Service System
Authors: Yi Wei
Published: May 2022

The ant colony algorithm is based on the real ant colony foraging behavior research algorithm, based on the ant colony algorithm university teaching management service system, through the development of one-click automatic course scheduling, drag-and-drop Manual course scheduling, the multi-mode, service-oriented perspective to promote college teaching management, greatly improve the efficiency of college teaching management services, fully adapt to the intelligent college teaching management environment. Based on the ant colony algorithm, this paper analyzes the background of the application of ant colony algorithm in university teaching management service system, and puts forward the application strategy of ant colony algorithm in University Teaching Management Service System.
Research on the Integration of Information Technology and Ideological and Political Course under the Background of Artificial Intelligence
Authors: Hua Xinxiang
Published: May 2022

Under the artificial intelligence environment, the integration of information technology and curriculum teaching is deepening, which provides an important impetus for optimizing the classroom teaching form, integrating high-quality resources and promoting the three-dimensional upgrade of curriculum teaching. In order to realize the ideal value of ideological and political education, it is necessary to construct an intelligent ideological and political course based on the mature application of information technology, fully display the vitality of ideological and political education classroom, in order to achieve the ideal effect of ideological and political education. Through the application of artificial intelligence technology as the research background, systematically explore the integration of information technology and ideological and political courses path.
China’s tourism development strategy in the post-pandemic era
Authors: Li Ce
Published: May 2022

The COVID-19 pandemic has seriously affected China’s tourism industry. The tourism industry is currently under difficult economic climate and the development policies also changed. However, the pandemic also provides opportunities for the transformation and upgrading of the tourism industry. It is crucial to understand timely and in detail how China’s tourism environment has changed in the post-pandemic era, so that we can develop better scientific strategies accordingly. In this study, Chinese tourism market is used as an example to analyze its development status and difficulties, providing a reference for the rapid recovery of the world tourism industry during post-pandemic period.
Research on evaluation method of periodical influence based on subdivision field
Authors: Shen Yan , Wen Haoyu , Wang Yaxin
Published: May 2022

As an important part of the science and technology evaluation system, evaluations theory and method of journal influence need targeted research and improvement. Based on the analysis of traditional journal evaluation methods, this paper put forward an evaluation index of the core journals in the field-Rf index, and constructed the influence evaluation model of academic journals in subdivided fields. Finally, through empirical research, it is proved that Rf index can accurately find high-quality journals in subdivided fields, which is beneficial to enrich and improve the journal evaluation system.
A blended collaborative learning model aiming to deep learning
Authors: Fang Qiqing , Liu Gen , Hu Yamin , Hu Yahui , Wang Jingjing
Published: May 2022

To solve the problem of mechanized blending and low-level cooperation in Blended Cooperative Learning, this paper proposes a Blended Cooperative Learning Model aiming to Deep Learning, which including the definition, key features and its framework. Through the application in the course of Radar Maintenance Engineering and Performance Parameters Measurement, our teaching practice shows that the students’ practical skills and scientific teamwork ability are significantly improved.
The data security problems discussion in application of library service platform
Authors: Zhao Xiangfei , Chang Yingcong , Feng Huizun , Huang Min
Published: May 2022

With new technology such as big data, cloud computing, artificial intelligence is widely used in the library, library service platform applies in many more libraries. Although big data collection, data analysis and cloud deployment provide a data basis of deploy operation for the platform, but meantime increases risk of data security, so the paper proposes several measures to ensure data security. Based on comparative analysis and literature research method, the paper analyzes qualitatively risk factors for data security from characters of library service platform. It expounds the necessity of data security, and proposes some measures respectively in each stage of data collection, data storage, data access and application, data sharing and updating, data security assessment, in order to promote greatly the level of data security for library.
Construction of moral education in college English with blended learning in the “internet+era”
Authors: Yang Chunye , Xu Defend , Yin Shihang
Published: May 2022

Moral education with blended learning is being heartedly discussed in college education. To foster students’ virtue through education is an important task of higher education. College English, with a vast number of students, is the key field to complete the task. To better enhance efficiency of moral education, this paper proposes that blended learning be an efficient method to construct moral education in college English. The paper presents an introduction to moral education, literature review of moral education and blended learning, questionnaire and data analysis, and corresponding measurements of how to construct moral education with blended learning. The paper finds out that (1)blended learning is a beneficial teaching approach in moral education (2) 88.16% (380 Ss in total) understand the concept “moral education” (3)teaching models with blended learning should be constructed so as to put moral education into practice (4)measures need to be proposed to integrate moral education in college English teaching.
Evaluation of logistics centre location based on weighted entropy
Authors: Shen Yiru
Published: May 2022

It is crucial to locate logistics centres for realising optimization of the the entire logistics process. A kind of effective and practical location evaluation method is in an urgent need. This study analyses principles of logistics centre location, constructs a relative evaluation index system and forms evaluation based on weighted entropy which is derived from the information entropy. A true example is lodged in this study is to indicate how this method eliminates subjective influence of traditional evaluation and increases evaluation precision, which introduces a new solution to site selection of logistics centres.
Using ARIMA and BP neural network to analyse incidence rate of AIDS in China
Authors: Yang Qiuying , Gao Xingyuan , Zhang Jinwang , Ma Hongli
Published: May 2022

To analyse the characteristics of AIDS transmission from incidence, we used ARIMA and BP neural networks to model the incidence of AIDS and predict them based on modelling. When the sequence is a small sample sequence and instability, the input of the BP neural network can use raw data or stationary sequence in the ARIMA. When using the stationary sequences of incidence as the input of the BP neural network, we can obtain the output corresponding to raw data by matrix operations. Results show that raw data combined with the stationary sequences as the input of the BP neural network can get better modelling results. Moreover, all the predicted values fall within the 95% CI of the ARIMA model. Although there was also a study (reference 14) using BP to predict the incidence of AIDS, it is the original used stationary series as the input of BP in this study.
Microwave response of chiral magnetic soliton in Yb(Ni1−xCux)3Al9
Authors: Meng Fanying , Liu Wei , Rahman Azizur , Zhao Jun , Wang Aina , Tong Wei , Fan Jiyu , Ma Chunlan , Ge Min , Pi Li , Du Haifeng , Zhang Lei , Zhang Yuheng
Published: May 2022

A chiral soliton lattice (CSL) is a topological spin-texture that has potential applications in next-generation spintronic devices. In this work, we performed angle-dependence of magnetization and electron spin resonance (ESR) investigations on the CSL host Yb(Ni1−xCux)3Al9 with x = 0.06 (YNCA). The angle-dependent magnetization reveals a peculiar variable magnetic anisotropy. The maximum magnetization axis is parallel to the ab-plane below the field of ∼35.7 kOe while shifts to the c-axis at higher fields. The microwave responses of the CSL helicoid and ferromagnetic resonance (FMR) of the forced ferromagnetic state (FFM) are observed and appear as two resonance lines on ESR spectra with the highest intensities in the ab-plane. When the external field is rotated from H⊥c to H//c, the resonance field Hr1 corresponding to the CSL helicoid decreases while Hr2 correlated with the FMR increases. Furthermore, the temperature-dependent ESR shows that the CSL persists until 15 K much higher than TC (6.4 K), which suggests a precursor phenomenon. The microwave response in YNCA provides a powerful tool for modulating and researching the CSL.