bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of the Colorectal Cancer Alliance's digital screening quiz and navigation model for promoting CRC screening.
Authors: Newcomer Kimberley Lynn , Guevara Alex , Christopher Dionne , Pearson Marianne , Brown Dammie
Published: January 2025

97

Background:
Evaluating the effectiveness of a Colorectal Cancer screening navigation model delivered in a digital platform offered by a patient advocacy organization. Designed as a digital screening quiz tool and live navigation to promote CRC screening, the Colorectal Cancer Alliance’s Screening Quiz is a risk stratification tool that connects respondents to live certified cancer care navigators delivering evidence-based interventions to increase CRC screening, education and patient and family support. The framework utilizes small and mass media, one-on-one education and patient navigation services to help address and reduce barriers to care. Research on these critical interventions shows that on-time screening for CRC leads to better outcomes.
Methods:
The Screening Quiz has been promoted through social sharing, community outreach, and media, including influencer campaigns to increase outreach to at-risk communities. Questions assess personal and family history, hereditary syndromes, and demographics to provide a CRC screening recommendation based on current USPSTF guidelines. Respondents overdue for screening are triaged to the Alliance’s patient navigation team. This interaction includes phone calls and emails for symptomatic individuals/high risk for CRC, telephone and email for average-risk uninsured, and emails for average-risk insured. At-risk individuals are connected to resources, such as financial assistance, free at-home screening tests, and colonoscopy scheduling services.
Results:
July 2022 to July 2024, the Screening Quiz provided over 50,000 screening recommendations. The median age of respondents was 46; 32% of respondents were between the ages of 45 to 64. Of the respondents, 29% were male and 71% were female. Most were White (79.2%), but nearly half of those who opted into navigation identified as BIPOC, including 16.7% Black/AA, 6.6% Asian, and 2.1% AI/AN. Additionally, 8.4% of respondents identified as ethnically Hispanic/Latino with another race. Most respondents were symptomatic (66.6%) but 6.5% were asymptomatic high-risk. These two groups represented 88% of 1,869 respondents triaged to patient navigation.
Conclusions:
The digital Screening Quiz, combined with live navigation, represents a promising approach for increasing CRC screening rates and addressing care gaps compared to traditional methods. The Alliance’s ability to engage at-risk communities through its national network of volunteers and partners, combined with evidence-based interventions, positions it well to continue closing screening gaps. Going forward, the Alliance aims to leverage its relationships with healthcare providers and community organizations further to expand the reach of its CRC screening efforts.
Phase 1/2 study of the trophoblast cell surface antigen 2 (TROP2) antibody-drug conjugate (ADC) sacituzumab tirumotecan (sac-TMT) as monotherapy or combination therapy in gastrointestinal cancers: LIGHTBEAM-02A.
Authors: Pishvaian Michael J. , Yoshino Takayuki , Weekes Colin D. , Ueno Makoto , Finn Richard S. , Jing Naimin , Hatogai Ken , Adelberg David E. , Oh Do-Youn
Published: January 2025

TPS846

Background:
There is a significant need for new tolerable and effective therapeutic options for colorectal cancer (CRC), pancreatic ductal adenocarcinoma (PDAC), and biliary tract cancer (BTC) that can provide survival benefit. TROP2 is expressed broadly in several cancers, including CRC, PDAC, and BTC. Sac-TMT (formerly MK-2870/SKB264) is an ADC consisting of a humanized antihuman TROP2 monoclonal antibody, a linker, and a cytotoxic belotecan–derivative topoisomerase I inhibitor. The nonrandomized, open-label, phase 1/2 LIGHTBEAM-02A study (NCT06428409) is being conducted to examine the safety and efficacy of sac-TMT in gastrointestinal cancers.
Methods:
Approximately 130 patients will be assigned to 1 of 3 cohorts based on their disease. Patients in cohort 1 (CRC; n ≤ 50) must have previously treated locally advanced or metastatic colorectal adenocarcinoma; patients in cohort 2 (PDAC; n ≅ 40) must have previously treated locally advanced or metastatic PDAC; patients in cohort 3 (BTC; n ≅ 40) must have previously treated locally advanced or metastatic BTC. Cohort 1 is included in a dose-escalation phase to determine the recommended phase 2 dose of sac-TMT when used in combination with fluorouracil and leucovorin and an efficacy phase. In the dose-escalation phase, patients will receive sac-TMT 3 mg/kg or 4 mg/kg intravenously (IV) every 2 weeks (Q2W) on days 1 and 15 of each 4-week cycle plus 2400 mg/m
2
fluorouracil IV infused over 46-48 hours Q2W and 400 mg/m
2
leucovorin IV Q2W; in the efficacy phase, patients will receive the recommended phase 2 dose of sac-TMT with the same chemotherapy regimen as the dose-escalation phase. Patients in cohorts 2 and 3 will receive sac-TMT 4 mg/kg IV monotherapy Q2W on days 1 and 15 of each 4-week cycle. The primary objectives are to evaluate safety and tolerability and objective response rate per RECIST v1.1 by blinded independent central review (BICR). Secondary objectives are to evaluate duration of response and progression-free survival per RECIST v1.1 by BICR and overall survival. Enrollment is ongoing.
Clinical trial information: NCT06428409
.
Correlates of Cetuximab Efficacy in Recurrent and Metastatic Head and Neck Squamous Cell Carcinoma Previously Treated With Immunotherapy
Authors: Park Jong Chul , Ahn Jong Seok , Merkin Ross , Patel Manisha , Wirth Lori , Roberts Thomas J.
Published: January 2025

PURPOSE

Immune checkpoint inhibitors (ICIs) are now first-line therapy for most patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), and cetuximab is most often used as subsequent therapy. However, data describing cetuximab efficacy in the post-ICI setting are limited.

METHODS

We performed a single-institution retrospective analysis of patients with R/M HNSCC treated with cetuximab, either as monotherapy or in combination with chemotherapy, after receiving an ICI. We extracted objective response rate (ORR), duration of treatment (DOT), and overall survival (OS) and compared them on the basis of patient characteristics. Multivariable models assessed associations between patient and tumor characteristics and outcomes.

RESULTS

We identified 70 patients treated with cetuximab after an ICI. The mean age was 67.6 years, with 60% having virus-associated HNSCC. Overall, the ORR was 21.4%, the median DOT was 1.9 months, and the median OS was 6.3 months. Patients receiving cetuximab with chemotherapy had a higher ORR (27.7%
v
8.7%) and longer median DOT but similar OS compared with monotherapy. Virus-independent HNSCC had higher ORR (28.6%
v
10.7%), longer DOT (3.3
v
1.2 months; hazard ratio [HR], 0.47 [95% CI, 0.25 to 0.90]), and longer OS (8.1
v
4.6 months; HR, 0.40 [95% CI, 0.19 to 0.83]). In multivariable models, virus-independent disease and negative smoking history were associated with improved OS. Concurrent chemotherapy, age, and sex were not associated with differences in OS. When assessing genomic data,
TP53
mutations were associated with improved DOT (HR, 0.33 [95% CI, 0.15 to 0.70]) and OS (HR, 0.38 [95% CI, 0.17 to 0.86]).

CONCLUSION

Cetuximab-based therapy shows limited efficacy in R/M HNSCC post-ICI, although outcomes were better in virus-independent HNSCC and nonsmokers. The findings may improve prognostication and patient selection for cetuximab after ICI in R/M HNSCC.
Impact of Weak Vibration Generated by a Refrigerator on Protein Aggregation
Authors: Kizuki Shinji , Wang Zekun , Yamauchi Satoru , Torisu Tetsuo , Uchiyama Susumu
Published: January 2025

Protein aggregates and particles in biopharmaceuticals can induce adverse immune responses in patients. Thus, suppression of the formation of protein aggregates and particles is important for the successful development of therapeutic proteins. Mechanical stresses, including agitation, are widely recognized as stress factors that generate protein aggregates and particles. However, although refrigerators and storage chambers generate weak vibration, there have been no studies of the impact of such weak vibration on aggregate and particle formation during storage. In this study, monomer loss and aggregate formation of a CTLA4-Ig were evaluated during storage in a refrigerator (having a vibration acceleration less than 0.006 G) with or without three vibration isolators. The vibration isolators reduced the vibration acceleration, thereby decreasing the rate of monomer loss and nanometer-sized aggregate formation. The increase in the aggregation rate due to the weak vibration was not mitigated by adding poloxamer 188 or eliminating the air–liquid interface, which are processes known to be effective in preventing protein aggregation due to mechanical stresses. Thus, reducing vibration should be an effective way to mitigate the risk of aggregate formation.

Graphical Abstract
Maternal Exposure to Ozone During Implantation Promotes a Feminized Transcriptomic Profile in the Male Adolescent Liver
Authors: Dye Janice A , Stewart Erica J , Schladweiler Mette C , Nguyen Helen H , Grindstaff Rachel D , Padgett William T , Fisher Anna A , Miller Colette N
Published: January 2025

Maternal exposure to ozone during implantation results in reduced fetal weight gain in rats. Offspring from ozone-exposed dams demonstrate sexually dimorphic risks to high-fat diet feeding in adolescence. To better understand the adolescent hepatic metabolic landscape following fetal growth restriction, RNA sequencing was performed to characterize the effects of ozone-induced fetal growth restriction on male and female offspring. Pregnant Long–Evans rats were exposed to filtered air or 0.8 ppm ozone for 4 hours on both gestation days 5 and 6 (n = 6/group). At approximately postnatal day 48, liver tissue was obtained for RNA sequencing from offspring. Peri-implantation exposure to ozone in the dam had greater effects on hepatic gene expression in male offspring than in the females. Interestingly, heatmaps of these differentially expressed genes suggested that male offspring from ozone-exposed dams had a transcriptomic pattern like that of female offspring. Using a filtered set of highly female-predominant genes (n = 390), 57% were upregulated in the male offspring from ozone-exposed dams. Upregulated canonical pathways included sirtuin and orexin signaling, estrogen receptor signaling, and integration of energy metabolism. Relatively few genes altered in the male offspring from ozone-exposed dams were associated with endpoints of sexual maturity, signifying the likely source of the observed feminization was not attributed to sex hormones. This study provides initial evidence that growth restriction in utero may increase the risk of hepatic feminization in male offspring. Additional work is needed to further understand the relationship between developmental undernutrition and feminization in the male liver.
P-60 LATE-ONSET THYROID EYE DISEASE IN A PATIENT WITH MULTIPLE COMORBIDITIES: A CASE REPORT
Authors: Abd Al Razq Zaid Qahtan , Khudhair Mahmood Shakir
Published: January 2025

Introduction

Thyroid eye disease (TED )is an autoimmune condition that affects the orbit around the eye, leading to inflammation and tissue remodeling. It is commonly associated with Graves’ disease but can also occur in other thyroid disorders. TED typically manifests within a few years of thyroid dysfunction, but late-onset cases, especially decades after thyroidectomy, is rare. This case report highlights a unique presentation of TED 34 years post-thyroidectomy in a patient with multiple comorbidities, including hypertension, type 2 diabetes mellitus, ischemic heart disease, and atrial fibrillation.

Clinical Case

A 75 years female with Hypertension, Type 2 Diabetes Mellitus, Ischemic Heart Disease & Atrial Fibrillation

Total Thyroidectomy: Performed in 1989 due to hyperthyroid disease, with no history of radioactive iodine ablation.

Presenting Symptoms:Red and gritty eyes, first presented in June 2023.

Clinical Findings:Orbital Examination: the patient was diagnosed with mild active thyroid eye disease.Neck Ultrasound: Showed very small residual thyroid tissue.TSH Receptor Antibody Test: Modestly elevated levels.Ophthalmologist consultation: prove the diagnosis of TED.

Laboratory Investigations:HbA1c: 9.1%Random Blood Glucose: 243 mg/dLTSH: 26 mIU/L

Medications:Thyroxine: 100 micrograms per daySitagliptin/metformin: 50/1000 mg twice dailyDigoxin: 0.25 mg dailyWarfarin: 3 mg dailyValsartan/HCT: 160/12.5 mg

Initial Management:Advised strict compliance with thyroxine therapy to normalize TSH levels.Added basal insulin and adjusted oral anti-diabetic therapy for tighter diabetes control.Recommended the use of artificial tears to keep eyes well-lubricated.Prescribed selenium supplementation.Referred to ophthalmologist for further evaluation.

Follow-Up:2 Months: HbA1c improved to 8.1%, TSH decreased to 8 mIU/L, and blood pressure and cardiac arrhythmia were well controlled. Bilateral orbital examination showed significant improvement.6 Months: The condition progressed to mild inactive thyroid-associated eye disease. TSH receptor antibodies were just above normal, and TSH normalized to 2.1 mIU/L.

Conclusion

This case illustrates the potential for TED to manifest many years after thyroidectomy, particularly in the presence of comorbid conditions. The patient’s non-compliance with thyroxine therapy and poorly controlled diabetes likely contributed to the exacerbation of her symptoms. The modestly elevated TSH receptor antibody levels and the presence of residual thyroid tissue further support the autoimmune activity.

This case underscores the importance of long-term monitoring and comprehensive management of thyroid and associated conditions.

While maintaining a euthyroid state is crucial for controlling thyroid eye disease, the impact of managing other comorbidities on TED control remains an area for further research.Figure 1:Thyroid Eye disease.
P-68 A CHALLENGING CASE OF HYPOTHYROIDISM
Authors: Omer Buzaid Najat
Published: January 2025

Introduction

Hypothyroidism is a common disease. L thyroxine once reached the stomach, undergoes disintegration and dissolution, and the active ingredient must reach the actual site of absorption. Disintegration is highly affected by the type of the formulation, the fasted or fed state, the gastric residence time, and the gastric motor function. The dissolution process consists of the release of solute molecules from the solid phase to the liquid one. Gastric juice pH. food, drugs and H pylori can affect L thyroxine absorption.

Clinical Case

IAA; A 54 y old female patient, known case of follicular thyroid carcinoma (FTC) since 2013, managed with total thyroidectomy, multiple radioactive iodine doses due to residual tissue. Post operative hypocalcemia that was resolved within a year. She was doing well on L- thyroxine suppressive dose of 200mcg/d. In 2018; she was operated for breast carcinoma, received chemotherapy and tamoxifen tablets. She was doing well on L thyroxine suppressive dose 250 mcg/d taken one hour before breakfast on an empty stomach, and was in complete remission regarding FTC. She lost to follow up for nearly one year. Her investigations: TSH= 39.7 mu/l, FT4= 6 (normal= 6.5-22 pmol/l), hemoglobin= 10.7 g/dl, calcium 8.7 mg/dl (normal= 8.4-10.5mg/dl not on calcium tab), celiac and H pylori serological screening were negative. TSH after 3 months =12.8 mu/l, She denied non compliance, Dose of L- thyroxine increased and gluten free diet was tried and did not work, dose increased to 400mcg/d. She was lost to follow up and came after one year,TSH =80 mu/l. L-thyroxine absorption test was performed; and L thyroxine mal-absorption was confirmed. She was advised to crush L-thyroxine 400 mcg/day and take it with water. TSH after two months was =13, free T4 =14 (normal=6.5-22 pmol/l). Gastroscopy showed pan moderate edematous gastritis and moderate erosive duodenitis. Duodenal biopsy showed chronic inflammation, negative celiac disease or malignancy.

Conclusion

Thyroid hormone is important for growth of intestinal mucosa. Selective L thyroxine malabsorption in the present case could be related to poor drug compliance and chronically uncontrolled thyroid status lead to intestinal edema and malabsorption. The other explanation was that gastritis caused inability of the stomach to properly dissolve tablet preparations to yield the active ingredient. The good response to crushed L thyroxine, which was a method of giving the drug to infants, suggested L thyroxine malabsorption problem started from the stomach.
Perceived Stress During Late Pregnancy and Infant Body Composition at 1 Month
Authors: Yang Xiaoran , Eckel Sandrah P , Maldonado Luis E , Yang Tingyu , Chen Xinci , Vigil Mario , Toledo-Corral Claudia M , Dunton Genevieve F , Grubbs Brendan H , Al-Marayati Laila , Lerner Deborah , Lurvey Nathana , Habre Rima , Farzan Shohreh F , Bastain Theresa M , Breton Carrie
Published: January 2025

Context

Worldwide, obesity remains one of the most challenging crises with children being one of the most susceptible populations. The effect of maternal stress during pregnancy on newborn body composition, measured by fat mass and lean mass has, not been extensively studied.

Objectives

We evaluated the association between perceived stress during late pregnancy and infant adiposity at 1 month and assessed effect modification by infant sex and preterm birth.

Methods

Mother-infant dyads (N = 138) were included from the ongoing MADRES cohort. Maternal perceived stress during late pregnancy was measured by the 10-item Perceived Stress Scale (PSS), as a cumulative score, during the third trimester. Infant adiposity measures, collected at 1 month by EchoMRI, included weight, fat mass (FM), and lean mass with FM-related ratios derived. Multivariable linear regression models with interaction terms were performed.

Results

Most mothers reported low to moderate stress (mean ± SD PSS: 13.2 ± 5.6) during late pregnancy. A 1-SD higher PSS was associated with higher FM% (FM (g)/weight (g): β = 0.78%; 95% CI, 0.13-1.44) but we did not find significant associations for the other adiposity measures. Statistically significant effects of perceived stress on FM-related measures were observed in male infants and preterm infants (both P for interaction <.05) but were null among female infants or term infants.

Conclusion

In this predominately low-income Hispanic population, perceived stress during late pregnancy was associated with higher FM-related body composition measures during early infancy; this association was stronger among male and preterm infants compared to the overall population and other subgroups.
Psychometric properties of an instrument measuring monkeypox knowledge, perception, and beliefs of health threat in health science students in a middle-income country
Authors: Rivera-Lozada Oriana , Ipanaqué-Zapata Miguel , Rivera-Lozada Isabel Cristina , Castro-Alzate Elvis Siprian , Hernández-Romero Hebe , Gómez-Rivera Mariana , Bonilla-Asalde César Antonio
Published: January 2025

Objective This study aimed to establish the factor structure and reliability of the evaluation instrument measuring monkeypox (Mpox) knowledge, perception and beliefs of health threat in students of the health area in two universities of Peru during 2022. Methods The methodology used was psychometric in nature. The study variable on knowledge of Mpox was based on the instrument made by Ricco et al., carried out with health professionals, adjusted to Peru and administered to 416 students. Results The results showed adequate goodness-of-fit indicators with RMSEA and SRMR coefficients lower than 0.08 and a TLI lower than 0.90 and adequate reliability values for knowledge of Mpox (KR20=0.70 and α=0.73), with the perception of health threats being the one with the highest reliability (α=0.88 and Ω=0.89). Conclusions Having instruments that accurately reflect the knowledge, perception and beliefs of health students will make it possible to contribute significantly to the prevention, control and management of this disease and, at the same time, be prepared to address other challenges of public health in the future.
A reference genome for the eastern bettong (Bettongia gaimardi)
Authors: Silver Luke W , Edwards Richard J , Neaves Linda , Manning Adrian D. , Hogg Carolyn J , Banks Sam
Published: January 2025

Abstract The eastern or Tasmanian bettong (Bettongia gaimardi) is one of four extant bettong species and is listed as ‘Near Threatened’ by the IUCN. We sequenced short read data on the 10x system to generate a reference genome 3.46Gb in size and contig N50 of 87.36Kb and scaffold N50 of 2.93Mb. Additionally, we used GeMoMa to provide and accompanying annotation for the reference genome. The generation of a reference genome for the eastern bettong provides a vital resource for the conservation of the species.
Evaluation of the fintech era on the performance of Moroccan banks: analysis through non-performing loans
Authors: Sadok Hicham , El Hadi El Maknouzi Mohamed
Published: January 2025

Background This study aims to contribute to a better understanding of the impact of the financial technologies (fintech) era on the performance in the banking sector, measured through non-performing loans (NPL) and their coverage by provisions for NPL. It is a question of knowing whether banking investment in fintech makes it possible to better evaluate the granting of credits, and therefore makes it possible to reduce overdue credits. Methods To this end, the method used consists of using a regression analysis and a Pearson correlation applied to the financial data of Moroccan banks observed during two distinct periods, namely 2007-2014, considered pre-fintech, and the period 2015-2022, considered as the fintech period. Results With the emergence of the fintech era, investment in digital technology, which is supposed to help better assess credit applications, the Moroccan banking situation improved slightly compared to the pre-fintech period: bad debts have remained stable despite the significant increase in net banking income and the size of banking assets during the fintech era. Conclusions The implementation of financial digitalization has improved customer relationship management, credit risk analysis and loan monitoring services, which ultimately reduces non-performing loans and improves the coverage of non-performing loans by provisions. The main implication of the results allows us to deduce that the implementation of fintech makes it possible to have a positive impact on stabilizing non-performing loans despite increasing loan volumes, and is likely to serve as a lever for the inclusion of those excluded from banking services.
Case Report : Giant phyllodes sarcoma: Case Report of total mastectomy with immediate latissimus dorsi flap reconstruction – A surgical and aesthetic challenge
Authors: Toumi Dhekra , Cheikh Mohamed Chayma , Hajji Ahmed , Ghaddab Imen , Medemagh Malak , Lazreg Hanane , Ben Ali Yasmine , Alouani Sana , Hammedi Jawaher , Souilah Selma , Barouni Rihab , Ben Abdelhafidh Hiba , bouakez Sana , Mahfoudhi Thana , Zoukar Olfa , Bergaoui Haifa , Faleh Raja
Published: January 2025

Phyllodes tumor of the breast is a rare fibroepithelial tumor, constituting less than 1% of all breast neoplasms. These tumors are characterized by rapid stromal growth and can reach significant sizes, particularly in malignant cases, necessitating aggressive surgical management due to their high recurrence risk. In this case report, we present a 40-year-old Tunisian woman diagnosed with a giant phyllodes sarcoma. The patient experienced considerable physical and psychological impacts, including impaired mobility, body image disruption, and professional limitations. Clinical examination and imaging confirmed the presence of a large lobulated mass in the left breast, with no signs of distant metastasis. A multidisciplinary team recommended a total mastectomy with immediate reconstruction using a latissimus dorsi myocutaneous flap. This approach aimed to restore breast contour while addressing both oncologic and aesthetic needs. The procedure was successful, with the excised tumor weighing 7 kg. Postoperatively, the patient received close monitoring and psychological support, emphasizing the importance of a holistic approach to recovery. This case underscores the complexities of managing giant phyllodes sarcoma, highlighting the value of a timely surgical intervention combined with effective reconstructive techniques. It also emphasizes the need for individualized treatment plans that consider both functional and aesthetic outcomes to optimize patient recovery and quality of life
Leslie Marmon Silko i jej Opowiadaczka z Puebla Laguna. Kolaż autobiograficzny
Authors: Dżurak Ewa
Published: January 2025

Leslie Marmon Silko opublikowała Storyteller w 1981 r. To dzieło ukazało się na polskim rynku jako Opowiadaczka z Puebla Laguna (Wydawnictwo Tipi, 2024 r.). Jest to pierwsza książka Silko przetłumaczona na język polski. Forma dzieła wymyka się gatunkowym ramom, ale nazwa „kolaż autobiograficzny” wydaje się celna. W skład zbioru wchodzi osiem opowiadań, więcej niż 20 poematów, ponad 20 tekstów prozą oraz 26 czarno-białych zdjęć. Wszystkie elementy są ze sobą mocno powiązane, ale nie zawsze wprost. Struktura tomu przypomina pajęczą sieć z wychodzącymi z centrum promieniami wątków, które łączą koncentryczne spirale motywów. Przede wszystkim jest to hołd złożony sztuce opowiadania praktykowanej w Pueblu Laguna i kulturze tego obszaru. Celem tekstu jest zapoznanie czytelników z postacią Leslie Marmon Silko, autorką dotąd nietłumaczoną, zaprezentowanie książki polskiemu odbiorcy, przedstawienie propozycji jej odczytania oraz przybliżenie niektórych problemów pierwszego polskiego tłumaczenia.
The Impact of Digitization on Print Book Sales: Analysis Using Genre Exposure Heterogeneity
Authors: Sharma Siddhartha , Telang Rahul , Zentner Alejandro
Published: January 2025

Problem definition: The rise of digital channels has led to significant media market transformations. This paper studies whether and how digitization, sparked by the launch of Amazon Kindle in late 2007, affected print book sales. Methodology/results: To estimate the impact, we exploit the quasiexperimental variation in the popularity of digital books across different genres or subgenres. We employ difference-in-differences and other identification strategies, and we use print sales data on a large representative sample of book titles published in the United States from 2004 to 2015 across a variety of genres. Using various empirical specifications, we find that digitization significantly reduced print sales of adult fiction (the most popular genre in the e-book format) while having a much smaller impact on adult nonfiction and juvenile fiction. We further find that the effect for adult fiction is higher after the launch of the iPad (in 2010) and stronger for smaller publishers, the paperback version, and low-selling books. Managerial implications: Our findings provide book publishers with key inputs for optimal pricing and release strategies of different book formats. Our study also extends the vast yet growing academic literature on the impact of digital distribution channels on existing sales channels and can inform the policy debate concerning third-party digitization and its effect on physical sales.

Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2022.0594 .
Kajian Pengurangan Sampah pada TPS3R Kecamatan Gunung Anyar, Kota Surabaya
Authors: Fadhillah Mukhtar Reza , Agustina Wilujeng Susi , Herumurti Welly
Published: January 2025

Abstrak: Timbulan sampah Kecamatan Gunung Anyar Kota Surabaya mengalami peningkatan walaupun telah memiliki berbagai fasilitas pengelolaan sampah seperti TPS3R. TPS3R Gunung Anyar direncanakan mengelola sampah sebesar 1.161 ton/tahun, namun saat ini hanya mampu mengelola sampah sebesar 595 ton/tahun dengan residu 48,7%, melebihi batas yang seharusnya mampu dihasilkan oleh TPS3R sebesar 30%. Penelitian ini menganalisis kondisi pengelolaan sampah di TPS3R Gunung Anyar dan optimalisasi kinerjanya untuk mencapai target pengurangan sampah pemerintah. Metode yang digunakan pada perhitungan timbulan dan komposisi sampah mengacu pada SNI 19-3964-1994 dengan menggunakan metode load count analysis. Metode yang digunakan dalam analisis partisipasi masyarakat adalah penyebaran kuesioner dengan pembuatan kuesioner yang mengacu pada metode skala likert. Hasil penelitian ini menunjukkan bahwa TPS3R Gunung Anyar mampu menangani rata-rata 3.502 kg sampah per hari dengan densitas 264 kg/m³. Saat ini TPS3R Gunung Anyar memiliki tingkat pengurangan sampah mencapai 41,2% dengan residu 58,8%. Mayoritas masyarakat memiliki pengetahuan baik (72%) dan sikap positif (92%) terhadap pengelolaan sampah berbasis 3R, tetapi hanya 35% yang aktif berpartisipasi. Dua alternatif dianalisis sebagai rencana untuk meningkatkan pengurangan sampah. Alternatif pertama meliputi optimalisasi pemilahan dan jam kerja, dengan potensi pengurangan sampah 2.551 kg/hari (55%). Alternatif kedua, yang mencakup pengembangan lahan dan perubahan pihak ketiga, berpotensi mengurangi sampah hingga 3.244 kg/hari (70%).
Abstract: Municipal solid waste generation in Gunung Anyar District Surabaya City has risen despite having TPS3R facilities. TPS3R Gunung Anyar is designed to handle municipal solid waste of 1,161 tons/year, but currently, it manages only 595 tons/year, with a residue rate of 48.7%, exceeding the acceptable limit of 30%. This study examines municipal solid waste management at TPS3R Gunung Anyar and determines the performance optimization to meet government solid waste reduction targets. Determination of municipal solid waste generation and composition was conducted based on SNI 19-3964-1994 and load count analysis. Community participation was assessed using Likert-scale questionnaires. TPS3R Gunung Anyar handled an average solid waste of 3,502 kg/day with a density of 264 kg/m³. The facility achieved a reduction rate of 41.2%, with a residue of 58.8%. Most of the community had good knowledge (72%) and a positive attitude (92%) toward 3R waste management, but only 35% actively participated. Two alternatives were analyzed to improve solid waste reduction. The first alternative is optimizing sorting and working hours, potentially reducing solid waste by 2,551 kg/day (55%). The second alternative involves expanding the facility and changing waste collectors, with a potential reduction of up to 3,244kg/day (70%)
Use of a next-generation multilayered foam dressing in hard-to-heal wounds: a prospective, multicentre study
Authors: Ranire-Maguire Marisa , Caprioli Russell , Taylor Cristin , Rodger Rebecca , Thomas Andrew , Oropallo Alisha
Published: January 2025

Objective:

Hard-to-heal wounds present a significant healthcare challenge due to their complex aetiology, impact on quality of life (QoL) and consequent economic burden. The aim of this study was to assess the usability, safety and performance of a next-generation, multilayered foam dressing, ConvaFoam (Convatec Ltd., UK), in the management of indicated hard-to-heal wounds.

Method:

In this prospective, multicentre, interventional, non-comparator, open-label study, wounds included venous leg ulcers, arterial leg ulcers, diabetic foot ulcers and pressure injuries. The primary endpoint was percentage change in wound area at four weeks. Additional endpoints included percentage change in wound area at 12 weeks, satisfactory clinical progress (defined as ≥40% reduction in study wound area at four weeks), complete wound closure, adverse events, pain, QoL and health professional usability outcomes.

Results:

A total of 90 patients (109 wounds) were included in the full analysis set. The median percentage reduction in wound area from baseline was 47.88% (p<0.0001) at week 4 and 93.75% (p<0.0001) at week 12. Satisfactory clinical progress at four weeks was reported for 61 (55.96%) wounds. Complete wound closure by week 12 was observed in 43 (39.45%) wounds (p<0.0001). The median Wound Quality of Life-14 score improved from 55.36 at baseline, to 80.36 at week 12. Of the 2935 dressing applications, there were only two adverse events which were reported to be related to the study dressings. The majority of health professionals rated ease of application, exudate management, ease of removal and conformity as excellent.

Conclusion:

The ConvaFoam dressings were shown to be effective at reducing wound size and promoting healing in indicated hard-to-heal wounds, particularly diabetic foot and venous ulcers.
The Bad Science Behind Trans Medicine Bans
Authors: Wuest Joanna , Last Briana S.
Published: January 2025

ABSTRACT: In United States v. Skrmetti, the Supreme Court’s conservative justices are poised to uphold bans on medicine for transgender minors. According to Tennessee Attorney General Jonathan Skrmetti, who is defending his state’s ban, trans youth are not a vulnerable minority deserving of civil rights protections. Rather, they are the victims of dangerously uncertain medical practices.
Loose Ends: Eighteenth-Century Afterpieces and Queerer Pleasures
Authors: Wiehe Jarred
Published: January 2025

Abstract: In order to theorize the dynamic ways that eighteenth-century afterpieces engaged audiences and potentially resisted ideologies (especially heterosocializing sympathies and affect) circulated by the main play, this project examines Nicholas Rowe’s The Tragedy of Jane Shore and John Gay’s The What D’Ye Call It on the night of February 23, 1715. This case study traces how sympathies and sentiment can be mapped and remapped in the playhouse with main piece and afterpiece. After briefly describing how afterpieces were “added” to main plays, the project synthesizes queer temporality, space making, and affect to suggest that the double-feature feature of the playgoing experience is pleasurably messy, overlapping, and just plain weird. Next, by theorizing the heteronormativizing stage-making practices of Rowe’s she-tragedy such as heartbreaking monologues, men and women’s bodies shifting through lower and higher stage positions, and other pathetic spectacles, the project traces the space of the stage and the feelings in the playhouse as distinctly invested in creating a sentimental experience that confirms heteronormative gender complementariness. By following Jane Shore with a play that sends up the moral and affective underpinnings of the she-tragedy, Gay’s afterpiece reveals how audiences may have experienced contradictory and competing sentiments. Moving from tears to laughter (sometimes unsuccessfully), the audience experiences the space of the stage as a complex site for feeling heterosexuality. Finally, the spatial elements of afterpieces carry with them the potential to remap and rescript both bodies in space and affective ties to those bodies. If the visual cues of heterosexuality (which, through their ubiquitous performances throughout the era make heteronormativity) can be manipulated, rescripted, and burlesqued on the same stage in the same night, then these radical scenarios put pressure on how heterosexuality sustains itself through media.
Moving Away from the Marriage Plot: The Urban Gothic in Frances Burney’s Cecilia
Authors: Porter Elizabeth
Published: January 2025

Abstract: Most gothic scholarship argues that London did not serve as a setting for gothic fiction until the Victorian era. However, as this essay demonstrates, Frances Burney's Cecilia (1782) prefigures what has been categorized as the Victorian urban gothic. Burney depicts London as a gothicized space for a woman navigating the dysphoria and disorientation of the eighteenth-century marriage market. Via the urban gothic, Burney explores the spatial and narrative trajectories of her heroine in ways that investigate possibilities for women’s urban mobility and that critique problems with marriage and the marriage plot. Ultimately, Burney’s prefiguration of the urban gothic subverts the marriage plot as a device of closure. The open-endedness of the unconventional marriage plot allows readers to envision other spatial and narrative trajectories that could be available to the heroine.
Ali Baba in the News: Systems of Seriality in George Parker’s Newspapers
Authors: Lanning Katie
Published: January 2025

Abstract: This essay investigates George Parker’s 1724–25 serialization of Arabian Nights in his newspapers published for the poor, crime-ridden London neighborhood of Whitefriars. While the entirety of Parker’s serialization sat alongside crime reports and news from Tyburn, I focus particularly on the story of “Ali Baba and the Forty Thieves,” not only because its printing coincided with Parker’s coverage of the infamous criminal celebrity Jonathan Wild but also because the tale offers a microcosmic depiction of serial crime whose systemic properties speak across the sultan’s despotic reign in the text and toward England’s harsh yet ineffective approach to criminal justice, often called the Bloody Code. The structure of Arabian Nights invites readings of analogy across the diverse stories contained within the frame narrative, and such intertextuality only expands with Parker’s serialization. Embedding the tale of “Ali Baba” in a newspaper that was also actively reporting on Wild’s trial created new material possibilities of analogy; it invited readings across the oriental tale and local news. In each issue, this porous cross-reading trained Parker’s audience to conceive of individual crime stories as interconnected serial parts of some larger, endless whole. This essay argues that Parker’s serialization of Arabian Nights thus provided its readers a new lens through which to read crime not as a string of individual incidents but as evidence of the systemic and serial inefficacy of England’s Bloody Code.
“Noisy Pleasures” and “Noisy Evil[s]”: The Political Dimensions of Sound in Jane Austen’s Mansfield Park
Authors: Bolger Elizabeth
Published: January 2025

Abstract: In this essay, I demonstrate how Jane Austen uses sound (chatter, commotion, and silence) in Mansfield Park (1814) to create a conservative soundscape, one that associates reticence with the elite and noise with the lower classes. At the same time, I argue that Austen creates this soundscape only to break down its hierarchical assumptions about class. By considering her depiction of sound in relation to other eighteenth-century texts that discuss the politics of sound—Edmund Burke and Mary Wollstonecraft’s texts on the French Revolution, as well as Thomas Clarkson and Samuel Johnson’s texts on slavery—I delineate the implications of who and what makes noise in  Mansfield Park . Following Wollstonecraft’s lead, Austen suggests that the supposedly silent elite may refrain from speech when they are confronted with humanitarian topics but that they are often noisy and loud in order to promote their own selfish desires and interests. This behavior points not only to a hypocrisy among the elite, who claim to appreciate silence when they in fact produce their own noise, but also to their immorality, as they willfully suppress others in pursuit of their own gain.
Oceanic Wahhabism
Authors: Roberts Nicholas P.
Published: January 2025

Abstract: At some point around 1810, a leading Wahhabi theologian in the capital of the First Saudi State fielded an intriguing question: Although Wahhabi leaders preached the ideals of enmity and violence toward non-Wahhabi peoples, could Wahhabi merchants travel to non-Wahhabi lands, do business with non-Wahhabi persons, and reside among them while pursuing commercial agendas? The theologian answered yes. I argue that this question and its answer reveal a lived reality in Najd that historians have yet to fully uncover. The theologian’s answer reveals how Arabia’s interior where Wahhabism emerged was enmeshed alongside Arabia’s coasts within the broader Afro-Asian Indian Ocean world. Oceanic Wahhabism thus situates Najd, the emergence of Wahhabism and the First Saudi State as parts of an inter-regional world in which Najdi peoples helped forge, consolidate, and sustain political, social, and commercial connections before and after Wahhabism’s emergence. An oceanic, world historical framework highlights individuals, agendas, and events that add new dynamics to the standard tribes-religion-oil framework for studying Arabia and its history, and helps to continue uncovering a portrait of Arabia—interior and all—as integral to modern world history.
Papuan Children, Catholic Missionaries, and the Formation of Transimperial Networks in Late Nineteenth-Century Europe
Authors: Reichgelt Marleen , Jensz Felicity
Published: January 2025

Abstract: In 1890, the French Catholic Bishop Louis Couppé took Tolika to Kagai and Auguste to Kadalama from a mission station on German New Guinea on a tour to Europe. Within a year, these Papuan children—known by their European names Louis and Auguste—met the Pope in Rome, met members of the German imperial government in Berlin, spoke with influential anthropologists, church officials, and the general public in several North-West European countries. This article examines the children’s function in the circulation of missionary ideals of empire, colonial practices of governance, and notions of imperial belonging across national and imperial borders. We argue that children were central in the formation and coalescence of transimperial networks, but have been hitherto overlooked in historical studies. As children were considered not yet fully formed, various ideals of imperial subjecthood could be projected on to them that appealed to diverse nationalities and ideologies.
Beam quality improvement for small-channel coherent beam combining with laser beams arranged along non-uniform Fermat spiral
Authors: Gao Yang , Zhou Zhanrong , Wang Yingying , Geng Yi , Li Yutian , Chen Shasha , Liao Jiali , Zhang Wei
Published: January 2025

We propose a non-uniform Fermat spiral (NFS) array for small-channel
coherent beam combining. Owing to the non-uniform array density and
the changing distances between two consecutive channels, the combined
beam quality is naturally improved by the NFS array. All the factors
affecting the combined beam quality were analyzed in detail, comparing
with the hexagon array and the uniform Fermat spiral (UFS) array.
Experiments were carried out to verify the combined beam quality of
the small-channel optical system. It is demonstrated that the combined
beam quality of the NFS array is better than that of the UFS array.
The experimental results matched well with the numerical results.
3D-printed fiber-bundle fluorescence microscope for quantifying single-cell responses to high-power radiofrequency sources
Authors: O’Connor Sean P. , Cruz Santory Aryana J. , Clary Joseph E. , Sedelnikova Anna V. , Brawley Zachary T. , Kulow Ryan M. , Noojin Gary D. , Nelson-Rakofsky Kaitlin S. , Bixler Joel N. , Steelman Zachary A.
Published: January 2025

Modern telecommunications systems rely on the ubiquitous use of radiofrequency (RF) fields. To ensure the safety of living systems under RF exposure, standards have been developed which rely on observed thresholds that produce an adverse response. Unfortunately, real-time imaging of single-cell responses to high-peak power RF exposures is experimentally difficult, as high-power RF may damage sensitive electronics such as cameras or photodetectors, and any metal in the exposure zone (such as a microscope objective or translation stage) interacts with the RF by reflecting the RF field, acting as an antenna, or altering the dose delivered to the sample. In this work, we present a custom fluorescence microcopy system compatible with high-power RF environments. Our device uses a custom, 3D-printed objective consisting entirely of plastic and glass components as well as a coherent fiber bundle to relay light between the exposure zone and the fluorescence detection scheme. Our device was validated against a high-end commercial confocal microscope by comparing cellular responses to a well-characterized nanosecond pulsed electric field (nsPEF) stimulus delivered via an electrode pair. Our system performed well under extreme RF exposure, demonstrating continuous fluorescence imaging and maintenance of the focal plane despite >40°C temperature variation at the sample caused by high peak power free-field RF exposure at a frequency of 2.8 GHz. This system is intended to aid researchers in investigating real-time biological responses to radiofrequency and microwave sources.
Does background color influence the perception of facial expression? Adjustment to neutral expression by Caucasian and Japanese participants
Authors: Peromaa Tarja , Tiippana Kaisa , Qian Kun , Olkkonen Maria
Published: January 2025

Color is linked to emotions, with
the strongest link between red and anger. This study primarily addressed
whether a red background increases perceived facial angriness, using a
method that did not require explicit processing of either color or
emotional expression, in participants of two ethnicities (Caucasian and
Japanese) and genders (female and male). Their task was to adjust the
expression on a face to neutral. The face stimuli were image continua of
angry, neutral, and happy expressions presented on four background colors
(red, saturated red, green, and gray). The neutral points were not
influenced by background color or participants’ ethnicity, suggesting that
previous findings showing an enhancement of reported facial anger by a red
background were likely due to response biases rather than a perceptual
effect.
Physics informed image restoration under low illumination with simultaneous parameter estimation using 3D integral imaging and Bayesian neural networks
Authors: Krishnan Gokul , Lee Jiheon , Goswami Saurabh , Javidi Bahram
Published: January 2025

Image restoration aims to recover a clean image given a noisy image. It has long been a topic of interest for researchers in imaging, optical science and computer vision. As the imaging environment becomes more and more deteriorated, the problem becomes more challenging. Several computational approaches, ranging from statistical to deep learning, have been proposed over the years to tackle this problem. The deep learning-based approaches provided promising image restoration results, but it’s purely data driven and the requirement of large datasets (paired or unpaired) for training might demean its utility for certain physical problems. Recently, physics informed image restoration techniques have gained importance due to their ability to enhance performance, infer some sense of the degradation process and its potential to quantify the uncertainty in the prediction results. In this paper, we propose a physics informed deep learning approach with simultaneous parameter estimation using 3D integral imaging and Bayesian neural network (BNN). An image-image mapping architecture is first pretrained to generate a clean image from the degraded image, which is then utilized for simultaneous training with Bayesian neural network for simultaneous parameter estimation. For the network training, simulated data using the physical model has been utilized instead of actual degraded data. The proposed approach has been tested experimentally under degradations such as low illumination and partial occlusion. The recovery results are promising despite training from a simulated dataset. We have tested the performance of the approach under varying levels of illumination condition. Additionally, the proposed approach also has been analyzed against corresponding 2D imaging-based approach. The results suggest significant improvements compared to 2D even training under similar datasets. Also, the parameter estimation results demonstrate the utility of the approach in estimating the degradation parameter in addition to image restoration under the experimental conditions considered.