bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from the Russian Severe Asthma Registry (RSAR)
Authors: Belevskiy Andrey S. , Nenasheva Natalia M. , Kravchenko Natalia Yu. , Makar'iants Natalia N. , Kuntsev Dmitry A.
Published: August 2022

Aim. Creation of the "Russian register of patients with severe asthma" and obtaining data on the population characteristics of patients with severe asthma (SA), the prevalence of SA phenotypes, treatment outcomes and the degree of disease control.
Materials and methods. Observational non-interventional study, which consists in the data analysis obtained on the basis of registration cards of the Russian Register of Patients with Severe Bronchial Asthma, data collection in which was carried out on the Oracle XE platform. Statistical data processing was carried out using Power BI, PSPP and Microsoft Excel spreadsheets.
Results. The study included 4376 adult patients (mean age 60.613.5 years, 65% women) diagnosed with SA from 57 regions of Russia for the period from June 2018 to December 2021. T2 inflammation was detected in 94.8% of patients when determining blood eosinophils and IgE of blood serum; 69% of patients with SA corresponded to the allergic phenotype. 83.3% of patients had no control of BA and 53% had 1 or more exacerbations of BA per year. 8% of patients received systemic corticosteroids as a permanent therapy, while biologics 10.6%.
Conclusion. The vast majority of adult patients with SA correspond to the T2 phenotype, have uncontrolled asthma with a high frequency of exacerbations and reduced lung function. A more favorable course of the disease was noted in patients receiving biological therapy, which requires appropriate measures to increase the possibility of access to this type of therapy.
Pharmacoeconomics analysis of using a fixed combination of budesonide/formoterol in patients with asthma in the health care system of the Russian Federation
Authors: Zyryanov Sergey K. , Dyakov Ilya N. , Aisanov Zaurbek R.
Published: August 2022

Aim. To evaluate the budgetary impact of using budesonide + formoterol (Symbicort Turbuhaler) as maintenance therapy in real clinical practice compared with standard therapy for asthma of varying severity: for mild asthma with on-demand salbutamol; for moderate and severe asthma with the drug salmeterol + fluticasone and salbutamol on demand.
Materials and methods. A static mathematical model was built to assess the impact on the budget when introducing the drug budesonide + formoterol (Symbicort Turbuhaler) in the treatment of asthma into clinical practice from the point of view of the state. Demographic data was taken from the official data of the Federal State Statistics Service. Direct medical costs included the cost of medicines, the cost of hospitalization of patients associated with the development of asthma exacerbations, and the cost of scheduled outpatient visits. Indirect costs considered the loss of GDP due to hospitalization of patients against the background of asthma exacerbations. A one-way sensitivity analysis was performed to confirm the robustness of the study results.
Results. Assessment of direct costs in the treatment of mild, moderate and severe asthma showed that a gradual increase in the proportion of patients receiving the drug budesonide + formoterol (Symbicort Turbuhaler) over the years to 5.5, 7.7 and 9.7% accordingly, led to an increase in the cost of pharmacotherapy over 3 years by 1.7 billion rubles, while direct non-drug costs associated with the treatment of complications that developed during the treatment of asthma decreased by 8.3 billion rubles. Thus, the reduction in total direct costs amounted to RUB 6.7 billion. At the same time, indirect costs decreased by 6.0 billion rubles. The total reduction in all costs (direct and indirect) when switching patients to budesonide + formoterol (Symbicort Turbuhaler) amounted to 12.5 billion rubles. In addition, the use of the drug budesonide + formoterol (Symbicort Turbuhaler) resulted in a decrease in the number of exacerbations: in the first year by 3137, in the second by 4393 and in the third by 5534 cases. A total of 13 064 asthma exacerbations were prevented over 3 years.
Conclusion. Increasing the proportion of patients with asthma of varying severity receiving therapy with budesonide + formoterol (Symbicort Turbuhaler) will reduce the financial burden on both the healthcare system and the budgetary system.
Prevalence and clinical associations of iron deficiency in patients with decompensated heart failure, depending on the diagnostic criteria used for iron deficiency
Authors: Kobalava Zhanna D. , Lapshin Artem A. , Tolkacheva Veronika V. , Galochkin Svyatoslav A.
Published: August 2022

Aim. To compare the frequency of iron deficiency (ID) in patients with decompensated heart failure (HF), defined by international guideline criterion ferritin 100 ng/ml or ferritin from 100 to 299 ng/ml with TSAT20% (criterion A) and by bone marrow biopsy criterion TSAT19.8% and serum iron 13 mol/l (criterion B); to evaluate the effect of ID, diagnosed on the basis of different ID criteria, on NT pro-BNP, sST2, CRP levels and New York Heart Association (NYHA) functional classes (FC) distribution between groups with ID and without ID.
Materials and methods. The study included 223 patients (median age 73 [65; 82] years, 58% males) who were hospitalized to V.V. Vinogradov Moscow City Clinical Hospital No. 64 with decompensated HF. All patients underwent a standard physiological examination, laboratory and instrumental studies, including determination of NT-proBNP, sST2, CRP, and ferrokinetic parameters (serum iron, transferrin, ferritin). TSAT was calculated as: serum iron / transferrin 3.98. NYHA FC was determined according to Heart Failure Severity Rating Scale score. All patients underwent echocardiography to assess the ejection fraction of the left ventricle.
Results. According to criterion A ID was detected in 89% (n=199) of patients. There were no significant differences between levels of CRP, NT-proBNP and sST2. According to criterion B ID was detected in 70% (n=156) of patients. In the ID group, higher levels of CRP (15.1 mg/l vs 6.2 mg/l, p0.001), NT-proBNP (5422 pg/ml vs 2380 pg/ml, p0.001) and sST2 (59.6 ng/ml vs 42 ng/ml, p=0.02) were detected. Intravenous FCM admission according to current international guidelines (diagnosis of ID according to criterion A) is recommended to 57% of patients included in this study. Both methods formed groups with ID, in which patients had higher NYHA FC compared to groups without ID. According to current clinical guidelines, iron deficiency should be assessed according to method 1. More than half of patients (57, n=127) have indications for intravenous FCM to reduce risk of HF hospitalizations.
Conclusion. The frequency of ID in patients with decompensated heart failure varies from 70 to 89% depending on the criterion used to diagnose ID, but in any case, remains high. Intravenous FCM should be prescribed in 57% (n=127) of patients. Criterion B, validated against the gold standard of diagnostics, unlike criterion A, makes it possible to form groups of patients with ID and without ID, significantly differing in CRP, NT-proBNP, and sST2 levels.
Stress-induced arterial hypertension
Authors: Ambatiello Lali G.
Published: August 2022

Stress is considered as one of the factors associated with the development of many diseases, including the cardiovascular system. The history of studying stress as a risk factor for hypertension began in the first half of the 20th century and continued after the introduction of 24-hour blood pressure monitoring (ABPM) into clinical practice. Then it turned out that there is normotension, stable hypertension and latent hypertension: masked (when clinical BP is within the normal range, and arterial hypertension is recorded according to ABPM and/or self-monitoring of BP) and white coat hypertension (increased BP during a visit to the doctor when normal values of blood pressure according to ABPM or self-monitoring of BP). Currently, both variants of latent hypertension are classified as stress-induced arterial hypertension. Several models have been proposed for the study of stress, but two of them are more common in clinical studies: the Karasek model (based on an imbalance between job demands and job decision latitude) and the Siegrist model (based on an imbalance of effort and reward). There are only few studies in where attempts have been made to link the increase in BP with the parameters of stress response (for example, with hormonal levels) or genetic predisposition. The review discusses the most significant studies of stress-induced arterial hypertension published to date.
Rehabilitation in patients with chronic thromboembolic pulmonary hypertension
Authors: Sagaydak Olesya V. , Danilov Nikolay M. , Chazova Irina E.
Published: August 2022

For patients with pulmonary hypertension (PH) there have been no recommendations for physical rehabilitation for a long time, and in fact physical activity was discouraged. Nowadays, the position regarding exercise in patients with PH has changed studies have shown the safety and effectiveness of exercise in these patients. Most of the studies published to date on rehabilitation in patients with PH have assessed its effect on exercise tolerance. This review provides an overview of published studies and their conclusions on the effectiveness of rehabilitation in patients with chronic thromboembolic hypertension being as a complex therapy using medical and surgical methods of treatment and rehabilitation. The inclusion of rehabilitation in complex treatment allows to achieve patients highest possible tolerance to physical activity, increase in the functional class, quality of life and restore working capacity.
On the formation of cardiology in the USSR: who should be called its founders?
Authors: Borodulin Vladimir I. , Banzelyuk Egor N. , Topolyanskiy Aleksey V.
Published: August 2022

During the XX century, specialized clinical areas gradually emerged from the general body of internal medicine, among which cardiology became one of the first. The literature has not yet explicitly considered the question of who should be considered the founders of Russian cardiology. Our data suggest that D.D. Pletnev, G.F. Lang, N.D. Strazhesco, V.F. Zelenin, A.L. Myasnikov and E.I. Chazov exhaust the nominal composition of the founders of cardiology in the USSR.
Нospital outcomes of coronary artery bypass grafting in patients with coronary heart disease with previous percutaneous coronary intervention
Authors: Kremneva Lyudmila V. , Suplotov Sergey N. , Abaturova Olga V. , Stognii Nikita Iu. , Shalaev Sergei V.
Published: August 2022

Aim. Evaluation of the frequency hospital cardiovascular events in groups of patients with stable angina who underwent percutaneous coronary interventions (PCI) with stenting of the arteries before coronary bypass surgery, or who did not have previous myocardial revascularization.
Materials and methods. The 120 patients with stable angina who underwent routine coronary artery bypass grafting were examined. Group composition: Men 80.8%, age 587.6, duration of coronary heart disease 65.7 years, history of myocardial infarction (MI) 77.5%. Arterial hypertension was present in 92.5%, diabetes mellitus in 12.5% of patients. Multivessel coronary artery disease in 72.5% of patients. 28 (23.4%) patients had previously undergone PCI with stenting of the coronary arteries. The period from PCI to coronary bypass surgery was 2032.6 months. Coronary bypass surgery on-pump was performed in 88.3%, coronary bypass surgery on off-pump in 11.7%. The number of distal anastomoses ranged from 1 to 4.
Results. There were no differences in clinical and angiographic indicators, pharmacotherapy, and operation characteristics between the groups of patients who were subjected to or did not have PCI before coronary bypass surgery. There were no differences between the analyzed groups of patients in the frequency of cardiac death (0 and 1.1%, p=0.58), non-fatal MI (3.6% and 9.8%, p=0.29), stroke (0 and 1.1%, p=0.58), acute heart failure (11.7% and 34.8%, p=0.06), the number of patients with paroxysms of atrial fibrillation (28.6% and 17.4%, p=0.94), the proportion of patients with resternotomies (3.6% and 3.3%, p=0.94) and gastrointestinal bleeding (3.6% and 4.3%, p=0.86).
Conclusion. PCI with coronary artery stenting, prior to coronary bypass surgery, does not affect the frequency of post-operative hospital cardiovascular and hemorrhagic complications.
Chronic kidney disease in outpatients with arterial hypertension: clinical characteristics and treatment efficacy (according to the national registry)
Authors: Oschepkova Elena V. , Aksenova Anna V. , Orlovsky Alexey А. , Chazova Irina E.
Published: August 2022

Аim. To investigate the clinical characteristics and quality of treatment (according to the national guidelines) of patients with arterial hypertension (AH) and chronic kidney disease observed in primary health care.
Materials and methods. The study was carried out on the basis of the AH registry data (n=43 133; 20052019 years). Glomerular filtration rate (eGFR) was calculated using the CKD-EPI formula; renal structure and albuminuria were not evaluated. The analysis was performed using the SPSS software (version 22; SPSS Inc).
Results. The creatinine level was assessed in 60% of patients, 23.6% of them had decreased eGFR60 ml/ min/1.73 m2. The incidence of co-morbid CVD and type 2 diabetes in patients with hypertension increased markedly with a decrease in eGFR (14 groups): the incidence of coronary artery disease increased 1.8 times (up to 72.5%), myocardial infarction 1.7 times (up to 20.6%), chronic heart failure 2 times (up to 84.0%), atrial fibrillation 10 times (up to 18.3%), history of stroke 3.7 times (up to 15.3%) and type 2 diabetes 2.4 times (up to 32.8%). Achievement of target goals of CV risk factors was not enough: systolic BP less than 50% of patients, triglycerides less than 7%, LDL-C in high and very high CVD risk patients less than 13%.
Conclusion. Conducting timely assessment of renal function, drug therapy and lifestyle changes in patients with AH and decreased renal functional could prevent severe kidney damage, the development of CV complications, chronic renal failure and reduce mortality.
Withdrawal syndrome after tyrosine kinase inhibitors discontinuation in patients with chronic myeloid leukemia
Authors: Chelysheva Ekaterina Yu. , Petrova Anna N. , Shukhov Oleg A. , Bykova Anastasiia V. , Nemchenko Irina S. , Gurianova Margarita A. , Tsyba Nikolay N. , Turkina Anna G.
Published: August 2022

Background. Withdrawal syndrome (WS) a musculoskeletal pain after discontinuation of tyrosine kinase inhibitors (TKI) in patients with chronic myeloid leukemia (CML) has been described in the treatment-free remission (TFR) studies. The pathophysiological mechanisms and predisposing factors of WS have not been well established.
Aim. Our aim was to evaluate clinical features and factors associated with WS in the Russian cohort of CML patients who discontinued TKI therapy.
Materials and methods. WS was evaluated in total of 183 CML patients with chronic phase and sustained deep molecular response (DMR). WS was defined as a musculoskeletal pain newly observed after TKI cessation or as a worsening of previously observed symptoms.
Results. DMR loss free survival at 36 months was 49% and 43% in prospective and retrospective groups respectively (p=0.96) with mеdian (Me) time of observation 33 months (range 1136). WS was observed in 49 (27%) patients: grade 12 was in 45 (92%) patients, grade 3 in 4 (8%) patients. Me time to WS occurrence was 2 months (range 17), Ме duration of WS was 5 months (range 135). WS was resolved in 14 of 15 patients with molecular relapse after 13 months of TKI re-initiation and was decreased in 1 patient. WS was completely resolved in 31 of 34 patients who continued remained in TFR and decreased in 3 patients. WS was resolved spontaneously or with nonsteroidal anti-inflammatory drugs in 14 (45%) and 17 (55%) patients accordingly. Older age (p0.0001), longer duration of TKI therapy (p0.0001) and presence of locomotion system diseases (p=0.022) were observed in patients with WS. No WS was observed in pregnant patients (р0.001). Survival without DMR loss at 12 months after TKI stop was 66 and 42% in patients with and without WS accordingly (р=0.095).
Conclusion. The rate of WS was 27% that is in a good concordance with the data of the other TFR studies. A longer period of TKI exposure, older age and the history of locomotion system diseases were associated with the development of the WS. We found for the first time that WS was not observed in patients with pregnancy. There was no association of WS development and the rate of molecular relapses.
Cdh5-lineage–independent origin of dermal lymphatics shown by temporally restricted lineage tracing
Authors: Zhang Yan , Ortsäter Henrik , Martinez-Corral Ines , Mäkinen Taija
Published: August 2022

The developmental origins of lymphatic endothelial cells (LECs) have been under intense research after a century-long debate. Although previously thought to be of solely venous endothelial origin, additional sources of LECs were recently identified in multiple tissues in mice. Here, we investigated the regional differences in the origin(s) of the dermal lymphatic vasculature by lineage tracing using the pan-endothelialCdh5-CreERT2line. Tamoxifen-induced labeling of blood ECs at E9.5, before initiation of lymphatic development, traced most of the dermal LECs but with lower efficiency in the lumbar compared with the cervical skin. By contrast, when used at E9.5 but not at E11.5, 4-hydroxytamoxifen, the active metabolite of tamoxifen that provides a tighter window of Cre activity, revealed low labeling frequency of LECs, and lymphvasculogenic clusters in the lumbar skin in particular. Temporally restricted lineage tracing thus reveals contribution of LECs ofCdh5-lineage–independent origin to dermal lymphatic vasculature. Our results further highlight Cre induction strategy as a critical parameter in defining the temporal window for stage-specific lineage tracing during early developmental stages of rapid tissue differentiation.
Comparative functional genomics identifies unique molecular features of EPSCs
Authors: Malik Vikas , Zang Ruge , Fuentes-Iglesias Alejandro , Huang Xin , Li Dan , Fidalgo Miguel , Zhou Hongwei , Wang Jianlong
Published: August 2022

Extended pluripotent or expanded potential stem cells (EPSCs) possess superior developmental potential to embryonic stem cells (ESCs). However, the molecular underpinning of EPSC maintenance in vitro is not well defined. We comparatively studied transcriptome, chromatin accessibility, active histone modification marks, and relative proteomes of ESCs and the two well-established EPSC lines to probe the molecular foundation underlying EPSC developmental potential. Despite some overlapping transcriptomic and chromatin accessibility features, we defined sets of molecular signatures that distinguish EPSCs from ESCs in transcriptional and translational regulation as well as metabolic control. Interestingly, EPSCs show similar reliance on pluripotency factors Oct4, Sox2, and Nanog for self-renewal as ESCs. Our study provides a rich resource for dissecting the regulatory network that governs the developmental potency of EPSCs and exploring alternative strategies to capture totipotent stem cells in culture.
WIFI BASED SMART AGRICULTURE
Authors: R Bhat Anusha , B N Madhushree , M R Deekshitha , H S Naveen , J V Reddy Jeevitha
Published: August 2022

Smart agriculture is an emerging concept, because IOT sensors are capable of providing information about agriculture fields and then act upon based on the user input. The goal of this paper is to create a Smart Agriculture System that takes advantage of cutting-edge technologies like Arduino, IoT, and Wireless Sensor Network. The goal of the article is to use developing technologies, such as the Internet of Things (IoT) and smart agriculture with automation. The ability to monitor environmental variables is a key aspect in increasing the production of efficient crops. The invention of a system that can monitor temperature, humidity, wetness, and even disease detection in tomato leaves is a characteristic of this research. TCP/IP is used in the development of the application for the farmer's Smartphone. The system uses a duplex communication link based on a cellular-Internet interface, allowing data inspection and irrigation scheduling to be configured using an android application. The device has the potential to be beneficial in water-scarce, geographically isolated places due to its energy independence and low cost.
NETWORK AUTOMATION
Authors: Reddy M Shyam Prasad , S Dr.Ambareesh
Published: August 2022

In the traditional ways of networking, we have a lot of manual operations to complete any task in networking. This leads to a heavier cost in network management than the cost of the network. To overcome cost and efficiency in network configuration and management, we are automating the tasks using software, where they can control, configure and manage networks. In this project, we are upgrading the Arista device operating system by taking pre and post conformations using python. Networking programming is based on software networks, where scripting is used for network elements control.
TEXT SUMMARIZATION USING MACHINE LEARNING AND DEEP NEURAL NETWORK
Authors: R Sri Harsha , B S Sudeepu , Owais Mohammed
Published: August 2022

The creation of summaries and their evaluation have grown in popularity over time. The two primary techniques for creating summaries from a given text corpus are extractive text summarization and abstractive text summarization. To create abstractive and extractive summaries, a variety of techniques and methodologies are available. Using machine learning and deep neural networks, an automatic extractive and abstractive text summarization technique is developed. To produce a summary from a given text, the Extractive model utilizes (Spacy, TF-IDF Vectorizer, and Latent semantic Analysis algorithm (LSA)) and the Abstract model employs (Encoder-decoder RNN with LSTM units and attention mechanism). The goal of the model is to demonstrate the benefits of applying the Extractive and Abstractive approach to text summarization in practical settings.
AN ADVERSARIAL ROBUSTNESS ANALYSIS FRAMEWORK FOR CLASSIFICATION MODEL
Authors: Gor Megha , S K Sagar , Bannigol Sahana , Elci J Vikas MeelBrundha
Published: August 2022

In the ML/DL algorithms developed by researchers/developers, the only constraint faced by them is the robustness of the model. The model may be experimented with certain data sets but for the model to get tested with all the permutation and combination of data sets under different conditions is a challenge. For the model to give efficient and accurate results under all circumstances, the users are demanding a more robust model that has been analyzed thoroughly. We aim to create an algorithm that is unique, efficient and solves a real-world problem and build an Adversarial Robustness analysis framework that works on reinforcement learning, applies utility metrics of attacks and defense to give a comprehensive robustness report
IMPLEMENTATION AND DESIGN OF EYE SPY ATTENDANCE TRACKER
Authors: R Priyanka , Vignesh Tushar , M Shivashankar , M S Vinyas , M Shreyas
Published: August 2022

Artificial intelligence enabled computer vision allows for the automation of various processes, computer vision for face recognition and time tracking can be quintessential in sectors where attendance and presence of various individuals needs to be tracked efficiently with as much handsfree experience as possible by employing data training sets and deep learning algorithms. The integration of this system with a robust and secure database to register information creates an extremely useful system for automated attendance tracking with minimalist human intervention.
DIABETES PREDICTION USING MACHINE LEARNING
Authors: V Ajay , Dhas Andrew S , Sanchith Anish , K R Chandan , B V Vinay
Published: August 2022

Diabetes is a fatal chronic illness that adversely affects every system in the body. This disease affects many people, and its adverse effects cause a sizable number of sufferers to pass away each year. High blood glucose levels are a concern for diabetic patients. It is quite challenging to make a robust and accurate prediction of diabetes due to the tiny amount of labeled data and outliers (or incomplete data) in the datasets for diabetes. We are putting up a reliable framework for diabetes prediction in this literature. Untreated diabetes may result in hearing loss, renal damage, heart and blood vessel disease, poor wound healing, and a few skin problems. For the classification, early diagnosis, and prediction of diabetes, a machine learning (ML)-based strategy has been put forth.
INFRARED WIRELESS UNDERWATER COMMUNICATION SYSTEM
Authors: Palkar Shylesh , H C Sanjay , B Reddy Shreyank , H P Pavan , H Manoj Kumar
Published: August 2022

The Wireless communication has been booming in the recent years. However, not much has been done to accomplish communication in water in a wireless manner which can be useful in many scenarios. Most of the communication modes that are existing as of now are either not reliable or are very expensive. IR rays can pass through water and thus be used in case of line of sight for communication purpose in this medium. This IR communication using Keyboard uses two units both controlled by ATmega family microcontroller. Both of the units have IR trans-receivers as communicating agents. Keyboards are needed to be connected on both the ends to enter input to the system. The communication messages get displayed on the LCD connected to the system. The system communicates with confirmation key that is sent back by receiving unit to the sending unit. In this way wireless communication is implemented with great efficiency within a line of sight range of about 3-4 meters under the water with the help of IR wireless underwater Communication project.
Application of Student Standardized Patient in the Clinical Teaching of Acute Abdomen
Authors: Chang Xiaowei , Cai Yu , Jia Yuanyuan , Yan Pu , Ma Shuyun
Published: August 2022

Background: In recent years, with the gradual expansion of the scale of medical education, the shortage of medical teaching resources and the reluctance of patients to cooperate with teaching have become increasingly prominent. Objective: To explore the application effect of student standardized patient (SSP) in the clinical teaching of acute abdomen. Methods: Fifty-four fifth-year general medical students from class 1826 of the general department of The First Affiliated Hospital of Xi’an Medical University were selected as the research subjects and randomly divided into two groups, with 27 students in the experimental teaching group, and the remaining 27 students in the conventional teaching group. The experimental teaching group adopted the SSP teaching approach. The SSPs were generated from the training students of the hospital through the recruitment and training process of SSP. In this study, seven qualified SSPs were selected for the clinical teaching of acute abdomen. At the end of the course, a periodic assessment was held. The rank sum test was used to compare the excellent and good rates between the two groups, while t-test was used to compare the difference between the two groups. Results: The results showed that the excellent and good rate of the experimental teaching group was significantly higher than that of the conventional group, in which the difference between the two groups was statistically significant (p < 0.05). In terms of the assessment results, the theoretical scores and skills scores of the experimental teaching group were better than those of the conventional teaching group, in which the differences between the two groups were statistically significant (p < 0.05). Conclusion: Through the training of SSP for acute abdomen and its application in surgical teaching and examination, the superiority of SSP is emphasized. Although there are still some shortcomings in the application of SSP in clinical teaching, it is a relatively new and effective teaching method, and it will play an increasingly critical role in clinical skills training pertaining to the medical specialty.
Teaching Exploration and Practice of Integrating into Ideological and Political Education in the Course of Technology of Applied Cryptogram
Authors: Hu Xiaoming , Ma Chuang
Published: August 2022

This paper summarizes and classifies the teaching contents of technology of applied cryptogram course according to the knowledge points. At the same time, the ideological and political elements of the course are designed from the following perspectives; (1) Abiding laws and regulations, and using cryptographic technology for the protection of network security; (2) Enabling students to firmly establish the belief that “core technology should be independent, and China’s science and technology should be self-improvement.” Further, the ideology and political elements are integrated into different teaching contents according to the knowledge points around these two themes. This course balances the relationship among ideology and morality, knowledge ability and quality. It not only focuses on improving students’ learning interest and ability, but also cultivates students to establish the correct outlook on life and values. The practical application shows that the overall effect is good.
The Moderating Effect of Technostress on The Relationship between Personality Traits and Employee Turnover Intentions. (c2022)
Authors:   ,   Lebanese American University, Ghosn Myriam
Published: August 2022

Organizations all around the world face turnover, which is caused by multiple reasons, and one of them could be personality traits of the employees. The purpose of this study is to examine the nature of the relationship between personality traits and employee turnover intentions, while studying the moderating effect of technostress on this relationship. Technostress constitutes an important variable since recently, most employees are frequently using information and communication technologies (ICTs) at their work, which is causing them technostress. The nature of this research is quantitative, in which the relationship between the chosen variables has been measured using an online questionnaire, sent to respondents working in the Middle East. The data was later on analyzed through SPSS statistical software. The study finds that there is a negative relationship between personality traits and employee turnover intentions, and that technostress moderates, partially moderates some traits, and do not moderate others.
Job Insecurity and Organizational Citizenship Behavior, with the Moderating Roles of Positive Psychological Capital and Grit. (c2022)
Authors:   ,   Lebanese American University, Farroukh Nataly
Published: August 2022

Job Insecurity has been consistently on the rise as a result of Covid-19 and the simultaneous changes taking place as a consequence of current events. The purpose of this research is to analyze how Job Insecurity influences employees’ Organizational Citizenship Behaviors, and whether Positive Psychological Capital and Grit moderate this relationship. This study bridges the gap in the literature regarding the impact of job insecurity on employees’ organizational citizenship behavior during the Covid-19 pandemic. There are also limited studies that explore different personal resources like psychological capital and grit as potential moderators in this relationship. To test the hypotheses set in this study, data was gathered via email and link shared on social media platforms. Using SPSS software and Excel MegaStat, the data collected was analyzed. The empirical data shows that qualitative job insecurity has a negative relationship with organizational citizenship behavior, and positive psychological capital and grit are established as moderators to this relationship. Managers can alleviate job insecurity in the workplace by promoting positive psychological capital and grit amongst employees, both of which will sustain and promote organizational citizenship behavior even during difficult times.
Sternbergia Clusiana Bulb Ethanolic Extracts Induce Apoptosis in MCF-7 Breast Cancer Cells. (c2022)
Authors:   ,   Lebanese American University, Elias Nazira
Published: August 2022

Sternbergia is a genus of plants belonging to the Amaryllidaceae family which is a popular ornamental plant. Plant leaf and bulb extracts of various Sternbergia species have been proven to possess diverse significant biological effects and have been historically employed in traditional medicine. However, the anti-tumor effects of Sternbergia clusiana bulbs in particular has not been investigated to date. The present study explores the anti-cancer activity of the ethanolic extract of Sternbergia clusiana bulbs (SbBEE) on breast cancer MCF-7 cell line in vitro and deciphers the underlying molecular mechanism associated with it. Treatment of MCF-7 cells with SbBEE showed a dose- and time-dependent anti-proliferative effect along with the occurrence of numerous apoptotic hallmarks. A dose-dependent increase in apoptosis via induced DNA fragmentation was revealed via Cell Death ELISA as well as an increase in cellular fragmentation using flow cytometry. On a molecular level, western blot analysis showed an upregulation of pro-apoptotic proteins such as poly(ADP-ribose) polymerase (PARP), Bax/Bcl-2 ratio and caspase-9, with no alterations in caspase-8 levels, revealing the activation of the intrinsic apoptotic pathway. Moreover, SbBEE exposure caused a significant reduction in ROS production proposing a potent anti-oxidant potential. A number of chemical compounds that contributed to SbBEE’s pro-apoptotic activity on MCF-7 cells were detected by liquid chromatography coupled with mass spectrometry, including lycorine, 9S,13R-12-Oxophytodienoic acid (OPDA), fumaritine N-oxide, rhamnetin and ferulic acid. The data presented in this study reveal promising anti-cancerous effects of SbBEE on MCF-7 breast cancer cells in vitro that should be further evaluated in vivo.
Antibiotic Resistance, Virulence Factors and Whole-Genome Characterization of Enterobacter spp. and Klebsiella aerogenes isolated from hospitals in Lebanon. (c2022)
Authors:   ,   Lebanese American University, Ghafari Patricia
Published: August 2022

Enterobacter cloacae complex (ECC) members and Klebsiella aerogenes are Gram-negative, rod-shaped, opportunistic pathogens that cause healthcare-associated infections and significantly threaten immunocompromised patients. Despite their clinical importance, their resistant profile and pathogenicity are not well understood due to the scarcity of studies in Lebanon and worldwide. This study presents a comprehensive whole-genome-based characterization of multidrug resistant and hypervirulent ECC members recovered from clinical settings in Lebanon. Identification and classification of 21 Enterobacter species and three K. aerogenes, was performed through hsp60 genotyping and 16S rRNA gene sequencing and confirmed by whole-genome average nucleotide identity (wgANI). Enterobacter spp. (N=21) were divided into three different genetic clusters: cluster VIII, cluster VI and only one members facilitated the exchange of resistance determinants. Co-selection of resistance and virulence characteristics could have provided a selective advantage. This study confirmed the polyphyletic nature of ECC members and their potential to rapidly evolve and adapt through horizontal gene transfer (HGT). It also revealed the need to expand prevention measures, showed the importance of developing and maintaining surveillance practices to control the spread of these pathogens, and the inevitability of implementing strict infection control measures in healthcare facilities. mapping to cluster XI. Multi-locus sequence typing (MLST) was used to determine the clonality of the isolates and core-genome single nucleotide polymorphism (SNP) to study the phylogenetic relatedness. MLST typing revealed the clonal diversity and helped in identifying epidemic clones such as ST114. Antibiotic susceptibility testing showed that most isolates were extensively drug-resistant (XDR), and the majority resistant to carbapenems(n=22/24). in silico analysis and plasmid-based replicon typing (PBRT) confirmed that the horizontal gene transfer of conjugative plasmids among ECC members facilitated the exchange of resistance determinants. Co-selection of resistance and virulence characteristics could have provided a selective advantage. This study confirmed the polyphyletic nature of ECC members and their potential to rapidly evolve and adapt through horizontal gene transfer (HGT). It also revealed the need to expand prevention measures, showed the importance of developing and maintaining surveillance practices to control the spread of these pathogens, and the inevitability of implementing strict infection control measures in healthcare facilities.
Public Baths Built in the Urban Centers of Syria during the Mamluk Period. (c2022)
Authors:   ,   Lebanese American University, Hamasni Noura
Published: August 2022

Baths stood as one of the most significant public institutions found in Syria during the Islamic period. It was commonly known that baths structure grew from simple Roman and Byzantine models, yet they matured the most following their implementation in different urban contexts during the Mamluk period. Public Baths, becoming an essential element in urban life, have witnessed several changes on a social, economic and architectural levels. Yet, not all aspects have been covered. This paper highlights the various aspects and factors behind the bath’s significant growth. The paper’s main focus is on the great effect that the urban context had not only on the bath’s social and economic level but on its architectural variations in terms of plans and elevations.
Discussion on Quality Inspection and Control of Building Materials
Authors: Min Xiong
Published: August 2022

The development of modern construction industry has greatly increased the types of building materials, and at the same time, it has put forward higher requirements for the quality of buildings. In the process of selecting building materials, because a large number of fake and inferior products flooded the market, the quality of identification materials became a problem. In order for the building to meet the construction standards, it is necessary to establish and improve the material management system and strengthen the monitoring and management of the quality of construction materials.
Discussion on Construction Quality Control Measures of Building Decoration Engineering
Authors: Zhuang Qinglou , Zhuang Qingquan , Qiu Qinghua , Zhuang Xixian
Published: August 2022

Building decoration engineering is the secondary creation and improvement of the main structure of the building. Construction decoration engineering construction is the process of decoration design scheme into decoration entity. Its construction quality is not only constrained by the customer needs and the design scheme, but also needs to meet the relevant requirements of the national quality standards for building decoration engineering. The construction quality of building decoration project is affected by many factors. Starting from the definition and value of architectural decoration engineering, this paper interprets the quality requirements of architectural decoration engineering, and seeks for the elements affecting the quality of the project, as well as the correlation between the influencing elements. Then explore the quality control measures in the project construction, and elaborate from the perspective of the construction personnel management, construction technology improvement, design planning, construction planning and scientific management in the construction.
A RETÓRICA DE RUBEM BRAGA: Imagens que o autor constrói das mulheres em suas crônicas
Authors: Fonseca Helena Miyazaki , Carmelino Ana Cristina
Published: August 2022

Este artigo analisa crônicas de Rubem Braga que trazem em cena a figura da mulher. Considerando que, ao escrever, o autor não apenas desvela imagens de si, mas também dos outros, este artigo tem como objetivo identificar os ethé que Braga desvela das mulheres que são retratadas em seus textos. O estudo é fundamentado por teóricos da Retórica e da Nova Retórica, especificamente no que diz respeito à noção de ethos, caso de: Aristóteles (2015), Perelman e Olbrechts-Tyteca (2005), Eggs (2005), Reboul (2004), Ferreira (2010) e Fiorin (2015).
O ESPECTRO DO SILÊNCIO NA DINÂMICA FAMILIAR À LUZ DO FILME O VAZIO DO DOMINGO
Authors: Oliveira Laura Souza Eletherio de , Machado Rebeca Nonato
Published: August 2022

RESUMO

No contexto da psicoterapia de família, a investigação sobre a comunicação é uma dimensão crucial para o entendimento da dinâmica familiar. As interações familiares são permeadas de mensagens verbais e afetos, representados por experiências de silêncio que estabelecem sentidos singulares na convivência íntima entre os membros. Diante da complexidade do fenômeno do silêncio nas interações humanas, este estudo tem como objetivo refletir os significados variados e os desdobramentos do silêncio na interação familiar, a partir da revisão de literatura no campo da psicoterapia de família, em suas abordagens sistêmicas e psicanalíticas. Para complementar a discussão, analisamos o filme “O Vazio do Domingo” (2018), utilizando o método análise temática a fim de ilustrarmos o espectro do silêncio. Refletiu-se que existe um silêncio na interação do grupo familiar de caráter repousante, desvelando o ápice da intimidade amorosa humana. Por outro lado, também há o silêncio que evidencia a perturbação dos vínculos e afetos, manifestando uma experiência emocional conflituosa, favorecendo a manutenção de um sofrimento compartilhado insuportável de ser vivenciado e representado.

Palavras-chave:  Silêncio; comunicação; interação familiar; segredo.
A New Standard for Classification of Countries: Social Integration and Politics-administration Relationship
Authors:   The Korea Association Of Governance Studies, Kim Phil
Published: August 2022

In the era of globalization in which the validity of the New Public Management (NPM) is suspected, comparative administrative research is necessary in order to strengthen the competitiveness of the government. This study presented the new national classification criteria for comparative administration as a social integration and political-administrative relationship, and classified 56 developing countries into four types through the fuzzy set ideal analysis method. As a result of the analysis, 10 countries with “integrated/administrative state” (Type A), 17 countries with “integrated/legislative state” (Type B), 16 countries with “non-integrated/administrative state” (Type C), and 10 countries with “non-integrated/legislative state” (Type D) were derived. This study contributes to future comparative administrative research by presenting new national classification criteria.
The Effect of Coaching Leadership of Senior Welfare Center Team Leader on Commitment to Service Quality: Verification of Mediating Effects of Role Clarity and Job Satisfaction
Authors:   The Korea Association Of Governance Studies, Oh Chang-Taek
Published: August 2022

The purpose of this study is to find out whether role clarity and job satisfaction play a mediating role in the process of coaching leadership affecting commitment to service quality. To this end, we analyzed the effective response data of a total of 333 people obtained through a questionnaire survey targeting frontline social workers at the senior welfare centers. As a result, coaching leadership directly had a positive effect on role clarity and commitment to service quality, role clarity directly had a direct positive effect on job satisfaction and commitment to service quality, and job satisfaction directly had a positive effect on commitment to service quality. In addition, coaching leadership indirectly had a positive effect on commitment to service quality through role clarity and job satisfaction. Finally, based on these results, the academic and practical implications of this study are presented.
Advocacy Coalition and Strategic Interaction in Korean Health Policy-making: Debates on the Privatization of Medical Services under the Park Geun-hye Government
Authors:   The Korea Association Of Governance Studies, Kim Soon-Yang
Published: August 2022

The purpose of this article is to analyze the political dynamics of The debates on medical services privatization under the Park Geun-hye government through the integrative analytical framework combining diverse components such as environmental contexts, belief systems, policy interests, strategic interaction and policy outputs. The Park Geun-hye government propelled medical services privatization centering the establishment of subsidiary companies of medical corporations and the introduction of the tele-medicine system. Business interest groups and hospital associations supported this idea. Proponents of medical services privatization put forward the economic value of privatization as its belief systems. Meanwhile, opponents of medical services privatization consisted of medical associations, opposition parties, and progressive- mined civic groups and trade unions. Some opponent members formulated an advocacy coalition, whereas medical professionals solely undertook collective actions to block medical services privatization. Opposition parties effectively made use of the filibuster institution to frustrate the legislation of the relevant laws for medical services privatization. Environmental context impacted the debates as a policy window. The policy intention of Park Geun-hye government to introduce medical services privatization was frustrated going through a series of political dynamics of policy debates. A concluding part discussed the characteristics of the debates and suggested policy implications.
Online college English teaching-learning amidst Covid-19 pandemic: Opportunities, challenges, and solutions
Authors: Fujiono Fujiono , Hidayati Nurul , Agustina Desi Kurniati , Hanayanti Citra Siwi
Published: August 2022

During Covid-19 outbreak, the lecturers and learners adjust to carry out class by applying online teaching-learning. Online teaching-learning built a new approach of communication between lecturers and learners in online course. This research aimed to describe online college English teaching-learning amidst Covid-19 pandemic: opportunities, challenges, and solutions. This research applied phenomenological research design in which the data sources were questionnaire and observation results dealing with the learners’ responses on teaching-learning amidst covid-19 emergency. It was found that almost all students studied English more accessible and flexible without came and met the lecturers in college, they could share information each other through online platform, nothing interaction among of them to prevent the outbreak. However, majority of college learners complained about financial, internet package, trouble networks, and time management that the learners sometimes got boring to study English. Dealing with the issues, Indonesia has contributed the internet package to assist the learners’ financial, and the lecturers has implemented games to create class more interactive, and energetic.DOI: 10.26905/enjourme.v7i1.6580