bluuebunny/crossref_metadata_2025 huggingface dataset:
Family-Based Obesity Prevention Interventions among Hispanic Children and Families: A Scoping Review
Authors: Soltero Erica G. , Peña Armando , Gonzalez Veronica , Hernandez Edith , Mackey Guisela , Callender Chishinga , Dave Jayna M. , Thompson Debbe
Published: August 2021

This scoping review examined intervention and sample characteristics of family-based obesity prevention interventions among Hispanic youth. This review also examined the degree to which existing interventions were culturally-adapted, acknowledged social determinants of health (SDoH), and collaborated with community stakeholders. A comprehensive search across Medline Ovid, Embase, Scopus, PsycInfo, and Pubmed was used to identify 13 studies primarily based in the U.S. (92.3%). Data was extracted by two independent reviewers. Most used a randomized control trial design (69.2%), a behavior change theory (84.6%), and reported moderate to high (≥70%) retention (69.2%). Studies targeted improvements in physical activity (69.2%) and fruit and vegetable intake (92.3%) through nutrition education, cooking demonstrations, and tastings. Younger children from low socioeconomic backgrounds (61.5%) were well represented. Most interventions were culturally-adapted (69.2%), all studies reported collaboration with stakeholders, yet only half used strategies that acknowledged SDoH (46.2%). To increase our understanding of the underlying mechanisms by which family-based approaches can reach and engage Hispanic youth and families, future studies should rigorously evaluate theoretical constructs, family processes, and SDoH that influence program participation and health behaviors. This information will guide the design and development of future interventions aimed at reducing obesity disparities among Hispanic youth.
Extension of Healthy Life Span of Dialysis Patients in the Era of a 100-Year Life
Authors: Inaba Masaaki , Mori Katsuhito
Published: August 2021

With both the elongation of hemodialysis (HD) duration resulting from the sophistication of HD technology and the increasing age at the time of HD initiation due to the aging society of Japan, the mean age of prevalent HD patients is increasing at an accelerating rate [...]
Elucidation of Melanogenesis-Associated Signaling Pathways Regulated by Argan Press Cake in B16 Melanoma Cells
Authors: Bourhim Thouria , Villareal Myra O. , Gadhi Chemseddoha , Isoda Hiroko
Published: August 2021

The beneficial effect on health of argan oil is recognized worldwide. We have previously reported that the cake that remains after argan oil extraction (argan press-cake or APC) inhibits melanogenesis in B16 melanoma cells in a time-dependent manner without cytotoxicity. In this study, the global gene expression profile of B16 melanoma cells treated with APC extract was determined in order to gain an understanding of the possible mechanisms of action of APC. The results suggest that APC extract inhibits melanin biosynthesis by down-regulating microphthalmia-associated transcription factor (Mitf) and its downstream signaling pathway through JNK signaling activation, and the inhibition of Wnt/β-catenin and cAMP/PKA signaling pathways. APC extract also prevented the transport of melanosomes by down-regulating Rab27a expression. These results suggest that APC may be an important natural skin whitening product and pharmacological agent used for clinical treatment of pigmentary disorders.
Association between Lifestyle Changes and at-Home Hours during and after the State of Emergency Due to the COVID-19 Pandemic in Japan
Authors: Nishijima Chiharu , Miyagawa Naoko , Tsuboyama-Kasaoka Nobuyo , Chiba Tsuyoshi , Miyachi Motohiko
Published: August 2021

Lifestyle changes during the coronavirus disease (COVID-19) lockdown have been previously examined, but there is limited understanding about changes after such restrictions were lifted. This study examines changes in lifestyle habits and body weight among the Japanese population with regard to the length of at-home hours both during (April to May) and after (September) the nationwide stay-at-home request compared to those before the COVID-19 pandemic (January 2020). An online survey was conducted in September 2020 involving 10,000 Japanese survey monitors, selected according to population distribution. During the stay-at-home request, 34% participants extended their at-home hours. More respondents in the group with extended at-home hours experienced an increase or decrease in total physical activity, snacking, food intake, alcohol drinking, and body weight than those in the group with nonextended at-home hours. Some of these changes had a trend according to age. The prevalence of most of these changes decreased when at-home hours returned to normal after the stay-at-home request period; however, increased alcohol consumption and increased or decreased body weight persisted. Our findings suggest that close monitoring for further health outcomes and age-appropriate measures to encourage favorable health behaviors is needed.
A Comparison of Pathogenicity and Virulence of Three Porcine Circovirus Type 2 (PCV2) Genotypes (a, b, and d) in Pigs Singularly Inoculated with PCV2 and Dually Inoculated with Mycoplasma hyopneumoniae and PCV2
Authors: Oh Taehwan , Suh Jeongmin , Park Kee Hwan , Yang Siyeon , Cho Hyejean , Chae Chanhee
Published: August 2021

The objective of this study was to compare the virulence of three different porcine circovirus type 2 (PCV2) genotypes (PCV2a, PCV2b, and PCV2d) in pigs infected with either one of these three PCV2 genotypes versus pigs dually inoculated with Mycoplasma hyopneumoniae and PCV2. Pigs were inoculated intratracheally with M. hyopneumoniae at 4 weeks of age followed by another intranasal inoculation at 6 weeks of age with one of three PCV2 genotypes. Dual infection with two pathogens produced moderate and severe dyspnea, lethargy, and reduced weight gain in pigs regardless of the PCV2 genotype evaluated compared with pigs only inoculated with PCV2. The overall levels of PCV2d viremia and severity of lymphoid lesions, and PCV2-antigen within lymphoid lesions were significantly higher in pigs dually inoculated with M. hyopneumoniae/PCV2d when compared with all other dually inoculated groups. The level of PCV2 viremia and the production of PCV2-associated lymphoid lesions did not differ significantly among PCV2a, PCV2b, and PCV2d single-inoculated pig groups. The results of this study demonstrated that M. hyopneumoniae potentiated the replication of PCV2d more than it did with the other PCV2 genotypes as measured by lymphoid lesion severity.
Alphavirus Virulence Determinants
Authors: Rangel Margarita V. , Stapleford Kenneth A.
Published: August 2021

Alphaviruses are important pathogens that continue to cause outbreaks of disease in humans and animals worldwide. Diseases caused by alphavirus infections include acute symptoms of fever, rash, and nausea as well as chronic arthritis and severe-to-fatal conditions including myocarditis and encephalitis. Despite their prevalence and the significant public health threat they pose, there are currently no effective antiviral treatments or vaccines against alphaviruses. Various genetic determinants of alphavirus virulence, including genomic RNA elements and specific protein residues and domains, have been described by researchers to play key roles in the development of disease, the immune response to infection, and virus transmissibility. Here, we focus on the determinants that are currently described in the literature. Understanding how these molecular determinants shape viral infections can lead to new strategies for the development of therapies and vaccines to combat these viruses.
Active Circulation of Madariaga Virus, a Member of the Eastern Equine Encephalitis Virus Complex, in Northeast Brazil
Authors: Gil Laura H. V. G. , Magalhaes Tereza , Santos Beatriz S. A. S. , Oliveira Livia V. , Oliveira-Filho Edmilson F. , Cunha João L. R. , Fraiha Ana L. S. , Rocha Brenda M. M. , Longo Barbara C. , Ecco Roselene , Faria Guilherme C. , Furtini Ronaldo , Drumond Safira R. M. , Maranhão Renata P. A. , Lobato Zélia I. P. , Guedes Maria Isabel M. C. , Teixeira Raffaella B. C. , Costa Erica A.
Published: August 2021

Madariaga virus (MADV) is a member of the eastern equine encephalitis virus (EEEV) complex that circulates in Central and South America. It is a zoonotic, mosquito-borne pathogen, belonging to the family Togaviridae. Disturbances in the natural transmission cycle of this virus result in outbreaks in equines and humans, leading to high case fatality in the former and acute febrile illness or neurological disease in the latter. Although a considerable amount of knowledge exists on the eco-epidemiology of North American EEEV strains, little is known about MADV. In Brazil, the most recent isolations of MADV occurred in 2009 in the States of Paraíba and Ceará, northeast Brazil. Because of that, health authorities have recommended vaccination of animals in these regions. However, in 2019 an equine encephalitis outbreak was reported in a municipality in Ceará. Here, we present the isolation of MADV from two horses that died in this outbreak. The full-length genome of these viruses was sequenced, and phylogenetic analyses performed. Pathological findings from postmortem examination are also discussed. We conclude that MADV is actively circulating in northeast Brazil despite vaccination programs, and call attention to this arbovirus that likely represents an emerging pathogen in Latin America.
Exosomes in Dogs and Cats: An Innovative Approach to Neoplastic and Non-Neoplastic Diseases
Authors: Diomaiuto Emanuela , Principe Valeria , De Luca Adriana , Laperuta Flaviana , Alterisio Chiara , Di Loria Antonio
Published: August 2021

Exosomes are extracellular vesicles with a diameter between 40 and 120 nm, which are derived from all types of cells and released into all biological fluids, such as blood plasma, serum, urine, breast milk, colostrum, and more. They contain proteins, nucleic acids (mRNA, miRNA, other non-coding RNA, and DNA), and lipids. Exosomes represent a potentially accurate footprint of the miRNA profile of the parental cell and can therefore be proposed as potential and sensitive biomarkers, both in diagnosing and monitoring a variety of diseases in humans and animals. Liquid biopsy offers itself as a non-invasive or minimally invasive, pain-free, time-saving alternative to conventional tissue biopsy. Exosomes in both human and veterinary medicine find their major application in neoplastic diseases, but applications in the field of veterinary cardiology, nephrology, reproduction, parasitology, and regenerative medicine are currently being explored. Exosomes can therefore be used as diagnostic, prognostic, and, in some cases, therapeutic tools for several conditions. The aim of this review was to assess the current applications of exosomes in veterinary medicine, particularly in dog and cat patients.
Development of Spanish Broom and Flax Dressings with Glycyrrhetinic Acid-Loaded Films for Wound Healing: Characterization and Evaluation of Biological Properties
Authors: Abruzzo Angela , Cappadone Concettina , Sallustio Valentina , Picone Giovanna , Rossi Martina , Nicoletta Fiore Pasquale , Luppi Barbara , Bigucci Federica , Cerchiara Teresa
Published: August 2021

The selection of an appropriate dressing for each type of wound is a very important procedure for a faster and more accurate healing process. So, the aim of this study was to develop innovative Spanish Broom and flax wound dressings, as alternatives to cotton used as control, with polymeric films containing glycyrrhetinic acid (GA) to promote wound-exudate absorption and the healing process. The different wound dressings were prepared by a solvent casting method, and characterized in terms of drug loading, water uptake, and in vitro release. Moreover, biological studies were performed to evaluate their biocompatibility and wound-healing efficacy. Comparing the developed wound dressings, Spanish Broom dressings with GA-loaded sodium hyaluronate film had the best functional properties, in terms of hydration ability and GA release. Moreover, they showed a good biocompatibility, determining a moderate induction of cell proliferation and no cytotoxicity. In addition, the wound-healing test revealed that the Spanish Broom dressings promoted cell migration, further facilitating the closure of the wound.
Physico-Chemical Characterization and In Vitro Biological Evaluation of a Bionic Hydrogel Based on Hyaluronic Acid and l-Lysine for Medical Applications
Authors: Alonci Giuseppe , Mocchi Roberto , Sommatis Sabrina , Capillo Maria Chiara , Liga Elsa , Janowska Agata , Nachbaur Lidia , Zerbinati Nicola
Published: August 2021

Hyaluronic acid (HA) is an endogenous polysaccharide, whose hydrogels have been used in medical applications for decades. Here, we present a technology platform for stabilizing HA with a biocrosslinker, the amino acid L-lysine, to manufacture bionic hydrogels for regenerative medicine. We synthetized bionic hydrogels with tailored composition with respect to HA concentration and degree of stabilization depending on the envisaged medical use. The structure of the hydrogels was assessed by microscopy and rheology, and the resorption behavior through enzymatic degradation with hyaluronidase. The biological compatibility was evaluated in vitro with human dermal fibroblast cell lines. HA bionic hydrogels stabilized with lysine show a 3D network structure, with a rheological profile that mimics biological matrixes, as a harmless biodegradable substrate for cell proliferation and regeneration and a promising candidate for wound healing and other medical applications.
Concomitant Cannabis Misuse and Associations with Depression, Pain and Substance Misuse among Patients Prescribed Opioids
Authors: Bryan M. Aryana , Charron Elizabeth , Adeoye-Olatunde Omolola , Brown Jennifer , Ghitza Udi , Winhusen T. John , Cochran Gerald
Published: August 2021

Background: Cannabis use is common among individuals with pain who are prescribed opioids, occurring in approximately 10% of this population. This study aims to explore the relationship between non-medical cannabis use and other health risks among individuals filling opioids at community pharmacies. Methods: This study was an exploratory secondary data analysis of a National Drug Abuse Treatment Clinical Trials Network (CTN)-sponsored study, Validation of a Community Pharmacy-Based Prescription Drug Monitoring Program Risk Screening, examining the relationship between risky cannabis use and depressive symptoms, pain, overdose, and other substance misuse among individuals filling opioid prescriptions in community pharmacies (N = 1440). Results: Participants reporting moderate- to high-risk compared to low-risk cannabis use were more likely to report depressive symptoms (adjusted OR = 1.67, 95% CI = 1.11–2.56), history of overdose (adjusted OR = 2.15, 95% CI = 1.34–3.44), and moderate- to high-risk use of alcohol (adjusted OR = 2.10, 95% CI = 1.28–3.45), opioids (adjusted OR = 2.50, 95% CI = 1.67–3.76), sedatives (adjusted OR = 2.58, 95% CI = 1.72–3.86), stimulants (adjusted OR = 4.79, 95% CI = 2.83–8.01), and tobacco (adjusted OR = 3.60, 95% CI = 2.47–5.24). Conclusions: Community pharmacies may be valuable sites for identifying, studying, and intervening with substance use problems.
Generation of Ultrabroad and Intense Supercontinuum in Mixed Multiple Thin Plates
Authors: Li Jing , Tan Wenjiang , Si Jinhai , Kang Zhen , Hou Xun
Published: August 2021

Supercontinuum (SC) generation using multiple thin plates is demonstrated with a femtosecond laser pulse. We propose an improved technique to obtain larger spectrum broadening and higher spectral intensity by employing mixed multiple thin plates with different thicknesses and materials. Furthermore, the spectrum has good stability, which is superior to that of the spectrum induced by the traditional single filament in bulk material. Our approach offers a route towards simple and stable SC generation for potential applications.
Raman Sensor for the Determination of Gas Solubility
Authors: Lipinski Gregor , Richter Markus
Published: August 2021

Efficient and environmentally responsible use of resources requires the development and optimization of gas separation processes. A promising approach is the use of liquids that are designed for specific tasks, e.g., the capture of carbon dioxide or other greenhouse gases. This requires an accurate determination of gas solubilities for a broad range of temperatures and pressures. However, state of the art measurement techniques are often very time consuming or exhibit other pitfalls that prevent their use as efficient screening tools. Here, we show that the application of Raman spectroscopy through a compact measuring system can simplify data acquisition for the determination of gas solubilities in liquids. To demonstrate that this approach is expedient, we determined gas solubilities of carbon dioxide in water for three isotherms T = (288.15, 293.15, 298.15) K over a pressure range from p = (0.5–5) MPa and in three imidazolium-based ionic liquids for one isotherm T = 298.15 K at pressures from p = (0.1–5) MPa. When compared to data in the literature, all results are within the reported uncertainties of the measurement techniques involved. The developed analysis method eliminates the need for a lengthy volume or mass calibration of the sample prior to the measurements and, therefore, allows for fast screening of samples, which can help to advance gas separation processes in scientific and industrial applications.
Cosmological Formation of (2 + 1)-Dimensional Soliton Structures in Models Possessing Potentials with Local Peaks
Authors: Murygin Boris S. , Kirillov Alexander A. , Nikulin Valery V.
Published: August 2021

Production of domain walls and string-like solitons in the model with two real scalar fields and potential with at least one saddle point and a local maximum is considered. The model is regarded as 2-dimensional spatial slices of 3-dimensional entire structures. It is shown that, in the early Universe, both types of solitons may appear. In addition, the qualitative estimate of the domain walls and strings formation probabilities is presented. It is found that the probability of the formation of string-like solitons is suppressed compared to that of domain walls.
Jute Responses and Tolerance to Abiotic Stress: Mechanisms and Approaches
Authors: Rahman Khussboo , Ahmed Naznin , Raihan Md. Rakib Hossain , Nowroz Farzana , Jannat Faria , Rahman Mira , Hasanuzzaman Mirza
Published: August 2021

Jute (Corchorus spp.) belongs to the Malvaceae family, and there are two species of jute, C. capsularis and C. olitorious. It is the second-largest natural bast fiber in the world according to production, which has diverse uses not only as a fiber but also as multiple industrial materials. Because of climate change, plants experience various stressors such as salt, drought, heat, cold, metal/metalloid toxicity, and flooding. Although jute is particularly adapted to grow in hot and humid climates, it is grown under a wide variety of climatic conditions and is relatively tolerant to some environmental adversities. However, abiotic stress often restricts its growth, yield, and quality significantly. Abiotic stress negatively affects the metabolic activities, growth, physiology, and fiber yield of jute. One of the major consequences of abiotic stress on the jute plant is the generation of reactive oxygen species, which lead to oxidative stress that damages its cellular organelles and biomolecules. However, jute’s responses to abiotic stress mainly depend on the plant’s age and type and duration of stress. Therefore, understanding the abiotic stress responses and the tolerance mechanism would help plant biologists and agronomists in developing climate-smart jute varieties and suitable cultivation packages for adverse environmental conditions. In this review, we summarized the best possible recent literature on the plant abiotic stress factors and their influence on jute plants. We described the possible approaches for stress tolerance mechanisms based on the available literature.
Screening for Higher Grain Yield and Biomass among Sixty Bread Wheat Genotypes Grown under Elevated CO2 and High-Temperature Conditions
Authors: Marcos-Barbero Emilio L. , Pérez Pilar , Martínez-Carrasco Rafael , Arellano Juan B. , Morcuende Rosa
Published: August 2021

Global warming will inevitably affect crop development and productivity, increasing uncertainty regarding food production. The exploitation of genotypic variability can be a promising approach for selecting improved crop varieties that can counteract the adverse effects of future climate change. We investigated the natural variation in yield performance under combined elevated CO2 and high-temperature conditions in a set of 60 bread wheat genotypes (59 of the 8TH HTWSN CIMMYT collection and Gazul). Plant height, biomass production, yield components and phenological traits were assessed. Large variations in the selected traits were observed across genotypes. The CIMMYT genotypes showed higher biomass and grain yield when compared to Gazul, indicating that the former performed better than the latter under the studied environmental conditions. Principal component and hierarchical clustering analyses revealed that the 60 wheat genotypes employed different strategies to achieve final grain yield, highlighting that the genotypes that can preferentially increase grain and ear numbers per plant will display better yield responses under combined elevated levels of CO2 and temperature. This study demonstrates the success of the breeding programs under warmer temperatures and the plants’ capacity to respond to the concurrence of certain environmental factors, opening new opportunities for the selection of widely adapted climate-resilient wheat genotypes.
The Effects of Cultivating Tobacco and Supplying Nitrogenous Fertilizers on Micronutrients Extractability in Loamy Sand and Sandy Soils
Authors: Lisuma Jacob B. , Mbega Ernest R. , Ndakidemi Patrick A.
Published: August 2021

This research was conducted to evaluate the trends of the extractable micronutrients boron (B), copper (Cu), iron (Fe), manganese (Mn), and zinc (Zn) in soils differing in textures and collected before tobacco cultivation, and in after unfertilized and fertilized (N10P18K24 and CAN 27%) plots. The soils and tobacco leaves were assessed on the contents of the micronutrients after unfertilized and fertilized tobacco cultivation. In soils, tobacco cultivation with fertilization increased the extractable Cu, Fe, Mn, and Zn by 0.10, 11.03, 8.86, and 0.08 mg kg−1, respectively, but decreased the extractable B by 0.04 mg kg−1. The effects of fertilization increased the extractable Cu, Fe, Mn, and Zn by 0.14, 14.29, 9.83, and 0.24 mg kg−1, respectively, but decreased B by 0.08 mg kg−1. The combination effects of tobacco cultivation and fertilization increased the extractable Cu, Fe, Mn, and Zn by 0.24, 25.32, 18.69, and 0.32 mg kg−1, respectively, but decreased the extractable B by 0.12 mg kg−1. The results revealed that the solubility of the extractable Zn, Mn, Cu, and Fe in soils were increased by both tobacco and fertilization, but the extractable B was decreased. The fertilization of the studied soils with NPK + CAN fertilizers significantly increased the concentration of the extractable micronutrients in tobacco leaves. Based on the findings of this study, further research must be conducted to investigate the effects of tobacco cultivation on soil health and fertility beyond considering only soil pH, SOC, micronutrients, and macronutrients. These studies should include the relationship between soil fertility (pH, texture, CEC, base saturation, etc.), micronutrients, and agronomic practices on the effect of tobacco cultivation on the extractability of B, Cu, Fe, Mn, and Zn.
Genetic and Environmental Factors Jointly Impact Leaf Phenolic Profiles of Iris variegata L.
Authors: Živković Uroš , Avramov Stevan , Miljković Danijela , Barišić Klisarić Nataša , Tubić Ljiljana , Mišić Danijela , Šiler Branislav , Tarasjev Aleksej
Published: August 2021

A plant’s main mechanism to diminish the effects caused by high free radical levels generated during high irradiance is the synthesis of various secondary metabolites. In addition to interspecies differences, their concentrations may be influenced by genetic, ontogenic, morphogenetic or environmental factors. We investigated the influence of genetic (genotypes from different natural habitats) and environmental (contrasting light regimes as well as successive parts of the vegetation period) variability on the accumulation of 10 selected phenolic compounds (phenolic acids, flavonoids, and xanthones) in Iris variegata genotypes. Genotypes originated from either sun-exposed or shaded natural habitats were transplanted to two experimental light treatments (high light intensity with a higher R/FR ratio and low light intensity with a lower R/FR ratio). Significant impacts of both genetic and environmental seasonal variability (spring, summer and fall during the vegetation period) on phenolic compound profiles were detected. Their highest amounts were detected in spring. The magnitude of difference between light treatments (high vs. low light intensity) and the direction of this change varied depending on the secondary compound class. Phenotypic correlations among the 10 analyzed secondary metabolites differed across the experimental light treatments and their number decreased from spring to fall.
Preparation of Bis[(3-ethyl-3-methoxyoxetane)propyl]diphenylsilane and Investigation of Its Cationic UV-Curing Material Properties
Authors: Liu Yuansheng , Huang Biwu , Zhou Wenbin , Chen Weiqing , Wu Yang
Published: August 2021

Precusor EHO(3-ethyl-3-hydroxymethyloxetane) was synthesized with diethyl carbonate and trihydroxypropane as the main raw materials. Intermediate AllyEHO(3-ethyl-3-allylmethoxyoxetane) was synthesized with 3-ethyl-3-hydroxymethyloxetane and allyl bromide as the main raw materials. Prepolymer bis[(3-ethyl-3-methoxyoxetane)propyl]diphenylsilane was synthesized with 3-ethyl-3-methoxyoxetane)propyl and diphenylsilane. Photoinitiator triarylsulfonium hexafluoroantimonate of 3% was added to the prepolymer, and a novel kind of the photosensitive resin was prepared. They were analyzed and characterized with FTIR and 1H-NMR. Photo-DSC examination revealed that the bis[(3-ethyl-3-methoxyoxetane)propyl]diphenylsilane has great photosensitivity. The thermal properties and mechanical properties of the photosensitive resin were examined by TGA and a microcomputer-controlled universal material testing machine, with thermal stabilities of up to 446 °C. The tensile strength was 75.5 MPa and the bending strength was 49.5 MPa. The light transmittance remained above 98%.
Characteristic Structural Knowledge for Morphological Identification and Classification in Meso-Scale Simulations Using Principal Component Analysis
Authors: Chiangraeng Natthiti , Armstrong Michael , Manokruang Kiattikhun , Lee Vannajan Sanghiran , Jiranusornkul Supat , Nimmanpipug Piyarat
Published: August 2021

Meso-scale simulations have been widely used to probe aggregation caused by structural formation in macromolecular systems. However, the limitations of the long-length scale, resulting from its simulation box, cause difficulties in terms of morphological identification and insufficient classification. In this study, structural knowledge derived from meso-scale simulations based on parameters from atomistic simulations were analyzed in dissipative particle dynamic (DPD) simulations of PS-b-PI diblock copolymers. The radial distribution function and its Fourier-space counterpart or structure factor were proposed using principal component analysis (PCA) as key characteristics for morphological identification and classification. Disorder, discrete clusters, hexagonally packed cylinders, connected clusters, defected lamellae, lamellae and connected cylinders were effectively grouped.
Development of a Multi-Layer Skin Substitute Using Human Hair Keratinic Extract-Based Hybrid 3D Printing
Authors: Choi Won Seok , Kim Joo Hyun , Ahn Chi Bum , Lee Ji Hyun , Kim Yu Jin , Son Kuk Hui , Lee Jin Woo
Published: August 2021

Large-sized or deep skin wounds require skin substitutes for proper healing without scar formation. Therefore, multi-layered skin substitutes that mimic the genuine skin anatomy of multiple layers have attracted attention as suitable skin substitutes. In this study, a novel skin substitute was developed by combining the multi-layer skin tissue reconstruction method with the combination of a human-derived keratinic extract-loaded nano- and micro-fiber using electrospinning and a support structure using 3D printing. A polycaprolactone PCL/keratin electrospun scaffold showed better cell adhesion and proliferation than the keratin-free PCL scaffold, and keratinocytes and fibroblasts showed better survival, adhesion, and proliferation in the PCL/keratin electrospun nanofiber scaffold and microfiber scaffold, respectively. In a co-culture of keratinocytes and fibroblasts using a multi-layered scaffold, the two cells formed the epidermis and dermal layer on the PCL/keratin scaffold without territorial invasion. In the animal study, the PCL/keratin scaffold caused a faster regeneration of new skin without scar formation compared to the PCL scaffold. Our study showed that PCL/keratin scaffolds co-cultured with keratinocytes and fibroblasts promoted the regeneration of the epidermal and dermal layers in deep skin defects. Such finding suggests a new possibility for artificial skin production using multiple cells.
Advanced Characterization of Organic Matter Decaying during Composting of Industrial Waste Using Spectral Methods
Authors: Biyada Saloua , Merzouki Mohammed , Imtara Hamada , Alajmi Mohamed F. , Elkarrach Karima , Mechchate Hamza , Conte Raffaele , Benlemlih Mohamed
Published: August 2021

To date, compost maturation monitoring is carried out by physical-chemical and microbiological analysis, which could be considered an overweening consumption of time and products. Nowadays, spectroscopy is chosen as a simple tool for monitoring compost maturity. In the present investigation, spectroscopy analysis was performed in the interest of corroborating the compost maturity. This goal was achieved by using the X-ray diffraction, infrared spectroscopy, and scanning electron microscopy. X-ray diffraction analysis showed the presence of the cellulose fraction in compost samples. At the same time, the intensity of pics decreased depending on composting time, thus proving that there was organic matter degradation. Infrared and scanning electron microscopy analysis allow for confirming these results. The correlation between spectroscopies analysis and physical-chemical properties was employed by partial least squares-regression (PLS-R) model. PLS-R model was applied to build a model to predict the compost quality depending on the composting time, the results obtained show that all the parameters analysis are well predicted. The current study proposed that final compost was more stabilized compared with the initial feedstock mixture. Ultimately, spectroscopy techniques used allowed us to confirm the physical-chemical results obtained, and both of them depict maturity and stability of the final compost, thus proving that spectral techniques are more reliable, fast, and promising than physical-chemical analyses.
Effects of Different Mixture Ratios of Methanol-Diesel on the Performance Enhancement and Emission Reduction for a Diesel Engine
Authors: Zhang Zhiqing , Tian Jie , Li Jiangtao , Ji Hongchen , Tan Dongli , Luo Jianbin , Jiang Yuxiu , Yang Dayong , Cui Shuwan
Published: August 2021

To improve the combustion and emission characteristics of diesel engines, methanol-diesel fuels with different mixing ratios (DM0, DM10, DM20, DM30, and DM40) were used to investigate the effects of methanol addition on the combustion and emission of a four-stroke diesel engine in terms of cylinder pressure, brake power, brake-specific fuel consumption, and nitrogen oxides, soot, and carbon monoxide emissions. Firstly, an improved entire diesel engine model was developed using AVL-BOOST software and validated by the experimental results. The results showed that the increase of methanol content in the fuel mixture had a negative impact on the performance characteristic of the diesel engine, but significantly improved the emission characteristic of the diesel engine. With the methanol ratio in the mixed fuel increased to 10%, 20%, 30%, and 40%, the cylinder pressure of the engine increased by 0.89%, 1.48%, 2.29%, and 3.17%, respectively. However, the power decreased by 3.76%, 6.74%, 11.35%, and 15.45%, the torque decreased by 3.76%, 6.74%, 11.35%, and 15.45%, respectively, and the brake specific fuel consumption increased by 3.77%, 6.92%, 12.33%, and 17.61%, respectively. In addition, with the methanol ratio in the mixed fuel increased to 10%, 20%, 30%, and 40%, the carbon monoxide emission decreased by 21.32%, 39.04%, 49.81%, and 56.59% and the soot emission decreased by 0.25%, 8.69%, 16.81%, and 25.28%, respectively. Therefore, the addition of methanol to the fuel can improve the combustion and emission characteristics of the engine.
The Sociotype of Dermatological Patients: Assessing the Social Burden of Skin Disease
Authors: Marron Servando E. , Tomas-Aragones Lucia , Marijuan Pedro C. , Mendivil-Nasarre Pablo Y. , Navarro Jorge
Published: August 2021

Skin diseases can be the cause of a significant psychosocial burden. However, tools to screen for social interaction difficulties and diminished social networks that affect the wellbeing and mental health of the individual have not been sufficiently developed. This study is based on the sociotype approach, which has recently been proposed as a new theoretical construct implemented in the form of an ad hoc questionnaire that examines the social bonding structures and relational factors. A pilot study was conducted in Alcañiz Hospital (Spain), with a study population of 159 dermatology patients. The results showed that in both subjective estimates concerning family, friends, work, and acquaintances, and in quantitative aspects, such as social contacts, duration of conversations, and moments of laughter, there were significant differences between the sample regarding diagnostic severity, dermatological diseases, and gender. The sociotype questionnaire (SOCQ) is a useful tool to screen for social difficulties in dermatological patients.
The Preliminary Analysis of Cave Lion Cubs Panthera spelaea (Goldfuss, 1810) from the Permafrost of Siberia
Authors: Boeskorov Gennady G. , Plotnikov Valery V. , Protopopov Albert V. , Baryshnikov Gennady F. , Fosse Philippe , Dalén Love , Stanton David W. G. , Pavlov Innokenty S. , Suzuki Naoki , Tikhonov Alexey N.
Published: August 2021

A preliminary description is presented of the well-preserved frozen mummies of two cubs of the extinct cave lion Panthera spelaea (finds of 2017–2018, Semyuelyakh River, Yakutia, eastern Siberia, Russia). The fossil lion cubs were found in close proximity, but they do not belong to the same litter, since their radiocarbon ages differ: the female (named ‘Sparta’) was dated to 27,962 ± 109 uncal years BP, and the male (named ‘Boris’) was dated to 43,448 ± 389 uncal years BP. The lion cubs have similar individual ages, 1–2 months. The general tone of the colour of the fur coat of Sparta is greyish to light brown, whereas, in Boris, the fur is generally lighter, greyish yellowish. It is, therefore, possible that light colouration prevailed with age in cave lions and was adaptive for northern snow-covered landscapes. The article discusses the results of computed tomography of cubs of the cave lion, the possible reasons for their death, and the peculiarities of their existence in the Siberian Arctic.
Religion and Life Satisfaction of Polish Female Students Representing Roman Catholic Affiliation: Test of Empirical Model
Authors: Wnuk Marcin
Published: August 2021

Religion is an important factor of life satisfaction for adolescents. This relationship is complex and depends on religiousness indicators used, religious affiliation, sex, age, and some cultural aspects. The aim of the study was to examine whether positive religious coping moderates the relationships between religious practices, as well as God’s support and life satisfaction. Additionally, the mediating role of religious commitment between faith and life satisfaction was tested. Methods: The sample in this study consisted of 315 Polish Roman Catholic female students. The following tools were used: the Satisfaction with Life Scale (SWLS), the Santa Clara Strength of Religious Faith Questionnaire (SCSORFQ), the Brief Religious Coping Scale (Brief RCOPE), the Religious Support Scale (RSS), and two one-item measures regarding frequency of prayer and Mass attendance. Results: The moderating role of positive religious coping between prayer, as well as God’s support and life satisfaction, was confirmed. Additionally, positive religious coping, God’s support, prayer, and Mass attendance mediated between faith and life satisfaction. Conclusion: The research has proven that faith negatively influenced adolescents’ life satisfaction both directly and directly through positive religious coping and Mass attendance. A beneficial indirect effect of faith on life satisfaction through God’s support and prayer was confirmed. It was also found that using positive religious coping with an above-average frequency of religious practices improved the life satisfaction among female students.
From Meditation to Bliss: Achieving the Heights of Progressive Spiritual Energy through Kirtan Singing in American Gaudiya Vaishnava Hinduism
Authors: Brown Sara Black
Published: August 2021

Kirtan is a musical worship practice from India that involves the congregational performance of sacred chants and mantras in call-and-response format. The style of kirtan performed within Gaudiya Vaishnava Hinduism is an expression of Bhakti Yoga, “the yoga of love and devotion”, and focuses on creating a personal, playful, and emotionally intense connection between the worshipper and their god—specifically, through words and sounds whose vibration is believed to carry the literal presence of Krishna. Kirtan is one of many Indian genres that uses musical techniques to move participants through a progression of spiritual states from meditation to ecstasy. Kirtan-singing has become internationally popular in recent decades, largely thanks to the efforts of the Hare Krishna movement, which has led to extensive hybridization of musical styles and cultural approaches to kirtan adapted to the needs of a diasporic, globalized community of worshippers. This essay explores the practice of kirtan in the United States through interviews, fieldwork, and analysis of recordings made at several Krishna temples and festivals that demonstrate the musical techniques that can be spontaneously deployed in acts of collective worship in order to create intense feelings of deep, focused meditation and uninhibited, expressive bliss.
Kinematic Synthesis and Analysis of the RoboMech Class Parallel Manipulator with Two Grippers
Authors: Baigunchekov Zhumadil , Laribi Med Amine , Mustafa Azamat , Kassinov Abzal
Published: August 2021

In this paper, methods of kinematic synthesis and analysis of the RoboMech class parallel manipulator (PM) with two grippers (end effectors) are presented. This PM is formed by connecting two output objects (grippers) with a base using two passive and one negative closing kinematic chains (CKCs). A PM with two end effectors can be used for reloading operations of stamped products between two adjacent main technologies in a cold stamping line. Passive CKCs represent two serial manipulators with two degrees of freedom, and negative CKC is a three-joined link with three negative degrees of freedom. A negative CKC imposes three geometric constraints on the movements of the two output objects. Geometric parameters of the negative CKC are determined on the basis of the problems of the Chebyshev and least-square approximations. Problems of positions and analogues of velocities and accelerations of the PM with two end effectors have been solved.
On the Structure and Kinematics of an Algerian Eddy in the Southwestern Mediterranean Sea
Authors: Poulain Pierre-Marie , Centurioni Luca , Özgökmen Tamay , Tarry Daniel , Pascual Ananda , Ruiz Simon , Mauri Elena , Menna Milena , Notarstefano Giulio
Published: August 2021

An Algerian Eddy, anticyclonic vortex generated by the instability of the Algerian Current in the southwestern Mediterranean Sea, is studied using data provided by drifters (surface currents), Argo floats (temperature and salinity profiles), environmental satellites (absolute dynamic topography maps and ocean color images) and operational oceanography products. The eddy was generated in May 2018 and lasted as an isolated vortex until November 2018. Its morphology and kinematics are described in June–July 2018 when drifters were trapped in its core. During that period, the eddy was slowly moving to the NE (~2 km/day), with an overall diameter of about 200 km (slowly growing with time) and maximal surface swirl velocity of ~50 cm/s at a radius of ~50 km. Geostrophic currents derived from satellite altimetry data compare well with low-pass filtered drifter velocities, with only a slight overestimation, which is expected as its maximum vorticity corresponds to a small Rossby number of ~0.6. Satellite ocean color images and some drifters show that the eddy has an elliptical spiral structure. The looping tracks of the drifters trapped in the eddy were analyzed using two statistical methods: least-squares ellipse fitting and wavelet ridge analysis, revealing a typical eccentricity of about 0.5, a wide range of inclination and a rotation period between 3 and 10 days. Clusters of drifters on the northeastern limb of the eddy were also considered to estimate divergence and vorticity. The results indicate convergence (divergence) and downwelling (upwelling) at scales of 20–50 km near the northeastern (northwestern) edge of the eddy, in agreement with the quasi-geostrophic theory. Vertically, the eddy extends mostly down to 250 m depth, with a warm, low-salinity and low-density signature and with geostrophic currents near 50 cm/s in the top layer (down to ~80 m) reducing to less than 10 cm/s near 250 m. Near the surface, colder water is advected into it.
Effect of Error in SO2 Slant Column Density on the Accuracy of SO2 Transport Flow Rate Estimates Based on GEMS Synthetic Radiances
Authors: Park Junsung , Choi Wonei , Lee Hyung-Min , Park Rokjin J. , Kim Seong-Yeon , Yu Jeong-Ah , Lee Dong-Won , Lee Hanlim
Published: August 2021

This study investigates the uncertainties associated with estimates of the long-range transport SO2 (LRT-SO2) flow rate calculated hourly using Geostationary Environment Monitoring Spectrometer (GEMS) synthetic radiances. These radiances were simulated over the Korean Peninsula and the surrounding regions using inputs from the GEOS-Chem model for January, April, July, and October 2016. The LRT-SO2 calculation method, which requires SO2 vertical column densities, wind data, and planetary boundary layer information, was used to quantify the effects of the SO2 slant column density (SCD) retrieval error and uncertainties in wind data on the accuracy of the LRT-SO2 estimates. The effects were estimated for simulations of three anthropogenic and three volcanic SO2 transport events. When there were no errors in the GEMS SO2 SCD and wind data, the average true LRT-SO2 flow rates (standard deviation) and those calculated for these events were 1.17 (± 0.44) and 1.21 (±0.44) Mg/h, respectively. However, the averages of the true LRT-SO2 flow rates and those calculated for the three anthropogenic (volcanic) SO2 events were 0.61 (1.17) and 0.64 (1.20) Mg/h, respectively, in the presence of GEMS SO2 SCD errors. In the presence of both errors in the GEMS SO2 SCD and wind data, the averages of the true LRT-SO2 flow rates and those calculated for the three anthropogenic (volcanic) SO2 events were 0.61 (1.17) and 0.61 (1.04) Mg/h, respectively. This corresponds to differences of 2.1% to 23.1% between the simulated and true mean LRT-SO2 flow rates. The mean correlation coefficient (R), intercept, and slope between the true and simulated LRT-SO2 flow rates were 0.51, 0.43, and 0.45 for the six simulated events, respectively. This study demonstrates that SO2 SCD accuracy is an important factor in improving estimates of LRT-SO2 flow rates.
Vegetation Filtering of a Steep Rugged Terrain: The Performance of Standard Algorithms and a Newly Proposed Workflow on an Example of a Railway Ledge
Authors: Štroner Martin , Urban Rudolf , Lidmila Martin , Kolář Vilém , Křemen Tomáš
Published: August 2021

Point clouds derived using structure from motion (SfM) algorithms from unmanned aerial vehicles (UAVs) are increasingly used in civil engineering practice. This includes areas such as (vegetated) rock outcrops or faces above linear constructions (e.g., railways) where accurate terrain identification, i.e., ground filtering, is highly difficult but, at the same time, important for safety management. In this paper, we evaluated the performance of standard geometrical ground filtering algorithms (a progressive morphological filter (PMF), a simple morphological filter (SMRF) or a cloth simulation filter (CSF)) and a structural filter, CANUPO (CAractérisation de NUages de POints), for ground identification in a point cloud derived by SfM from UAV imagery in such an area (a railway ledge and the adjacent rock face). The performance was evaluated both in the original position and after levelling the point cloud (its transformation into the horizontal plane). The poor results of geometrical filters (total errors of approximately 6–60% with PMF performing the worst) and a mediocre result of CANUPO (approximately 4%) led us to combine these complementary approaches, yielding total errors of 1.2% (CANUPO+SMRF) and 0.9% (CANUPO+CSF). This new technique could represent an excellent solution for ground filtering of high-density point clouds of such steep vegetated areas that can be well-used, for example, in civil engineering practice.
Remote Sensing Change Detection Based on Multidirectional Adaptive Feature Fusion and Perceptual Similarity
Authors: Xu Jialang , Luo Chunbo , Chen Xinyue , Wei Shicai , Luo Yang
Published: August 2021

Remote sensing change detection (RSCD) is an important yet challenging task in Earth observation. The booming development of convolutional neural networks (CNNs) in computer vision raises new possibilities for RSCD, and many recent RSCD methods have introduced CNNs to achieve promising improvements in performance. In this paper we propose a novel multidirectional fusion and perception network for change detection in bi-temporal very-high-resolution remote sensing images. First, we propose an elaborate feature fusion module consisting of a multidirectional fusion pathway (MFP) and an adaptive weighted fusion (AWF) strategy for RSCD to boost the way that information propagates in the network. The MFP enhances the flexibility and diversity of information paths by creating extra top-down and shortcut-connection paths. The AWF strategy conducts weight recalibration for every fusion node to highlight salient feature maps and overcome semantic gaps between different features. Second, a novel perceptual similarity module is designed to introduce perceptual loss into the RSCD task, which adds perceptual information, such as structure and semantic information, for high-quality change map generation. Extensive experiments on four challenging benchmark datasets demonstrate the superiority of the proposed network compared with eight state-of-the-art methods in terms of F1, Kappa, and visual qualities.