bluuebunny/crossref_metadata_2025 huggingface dataset:
Red blood cells in cerebrospinal fluid as possible inhibitory factor for enterovirus RT-PCR
Authors: Almeida Sérgio Monteiro de , Raboni Sônia Mara , Nogueira Meri Bordignon , Vidal Luine R. Renaud
Published: October 2016

ABSTRACT The presence of hemoglobin in samples are considered an important inhibitory factor for polymerase chain reaction (PCR). The aim of this study was to examine the influence of red blood cells (RBC)s in cerebrospinal fluid (CSF) as an inhibitory factor to reverse transcription polymerase chain reaction (RT-PCR) for enteroviruses (EV). Forty-four CSF samples from patients showing characteristics of viral meningitis were assessed for EV by RT-PCR. Viral RNA extracted with guanidine isothyocianate buffer and virus detection was performed by in-house nested PCR. Positivity for EV RT-PCR was higher in CSF samples without RBCs than in samples with RBCs: 13(26%) and 36(9.2%), p = 0.001. In the group with positive EV RT-PCR, the mean + SD CSF RBC was 37 ± 183 cell/mm3; the group with negative results had 580 + 2,890 cell/mm3 (p = 0.007). The acceptable upper limit for CSF RBCs that could not influence RT-PCR was 108 cells/mm3. CSF samples with negative results for EV RT-PCR have more erythrocytes.
PINK DISEASE, A REVIEW OF AN ASYMPTOMATIC BACTERIAL DISEASE IN PINEAPPLE
Authors: MARÍN-CEVADA VIANEY , FUENTES-RAMÍREZ LUIS ERNESTO
Published: October 2016

ABSTRACT Pink disease is an asymptomatic pineapple disease in the field and is evidenced with a reddark coloration when the infected fruit is processed to obtain products such as juice, jam, and preservatives. Tatumella morbirosei and T. ptyseos (formerly Pantoea citrea) have been demonstrated as causal agents. Although T. morbirosei and T. ptyseos have been well studied, there are currently no cost effective control methods in pineapple cultivation. The purpose of this review is to summarize the significant and updated research on the role of pink disease in pineapple.
RELATIONSHIP BETWEEN ESOPHAGITIS GRADES AND HELICOBACTER PYLORI
Authors: RIBEIRO Patrícia Fernanda Saboya , KUBRUSLY Luiz Fernandao , NASSIF Paulo Afonso Nunes , RIBEIRO Irma Cláudia Saboya , BERTOLDI Andressa de Souza , BATISTÃO Venessa Caroline
Published: October 2016

ABSTRACT Background: The Helicobacter pylori infection (HP) is related to the development of gastric lesions and lymphoma; however, it is not known if there is a relation with gastroesophageal reflux disease and reflux esophagitis. Aim: To evaluate HP's relationship with esophagitis in patients undergoing upper endoscopy. Methods: Observational, retrospective and cross-sectional study, being evaluated 9576 patients undergoing outpatient endoscopic examination during the period between January and December 2015. Were included patients with any esophageal alteration at the examination; greater than 18; of both genders; independent of the complaint or the reason for the examination, illness or drug use. Were excluded those with active bleeding during the examination and in use of anticoagulants. The variables gender, age, esophagitis and result of the urease test, were studied. For statistical analysis was used the Epi Info software 7.1.5.2. Results: Most of the samples consisted of women and the overall average age was 46.54±16.32 years. The presence of infection was balanced for gender: 1204 (12.56%) women and 952 (13.92%) men. Relating degree of esophagitis HP- and HP+ was observed that the type A was the most common (58.79%, n=1460); 604 (24.32%) had grade B; 334 (13.45%) grade C, and 85 (3.42%) grade D. In the relation between the grade of esophagitis with gender, esophagitis A was predominant in women and present in 929 (63.33%), followed by type B, 282 (46.68%), 136 C (40.71%) and D 30 (35.29%). In men 531 (36.36%) showed type A, 322 (53.31%) B, 198 (59.28%) C, and 55 (64.70%) D. Among the groups 40-50 and over 60 years there was a significant difference in whether have or not have HP+. Conclusion: There is no significant difference between HP infection and the different grades of esophagitis.
DIAGNOSTIC ACCURACY OF BARIUM ENEMA FINDINGS IN HIRSCHSPRUNG'S DISEASE
Authors: PEYVASTEH Mehran , ASKARPOUR Shahnam , OSTADIAN Nasrollah , MOGHIMI Mohammad-Reza , JAVAHERIZADEH Hazhir
Published: October 2016

ABSTRACT Background: Hirschsprung's disease is the most common cause of pediatric intestinal obstruction. Contrast enema is used for evaluation of the patients with its diagnosis. Aim: To evaluate sensitivity, specificity, positive predictive value, and negative predictive value of radiologic findings for diagnosis of Hirschsprung in patients underwent barium enema. Methods: This cross sectional study was carried out in Imam Khomeini Hospital for one year starting from 2012, April. Sixty patients were enrolled. Inclusion criteria were: neonates with failure to pass meconium, abdominal distention, and refractory constipation who failed to respond with medical treatment. Transitional zone, delay in barium evacuation after 24 h, rectosigmoid index (maximum with of the rectum divided by maximum with of the sigmoid; abnormal if <1), and irregularity of mucosa (jejunization) were evaluated in barium enema. Biopsy was obtained at three locations apart above dentate line. PPV, NPV, specificity , and sensitivity was calculated for each finding. Results: Mean age of the cases with Hirschsprung's disease and without was 17.90±18.29 months and 17.8±18.34 months respectively (p=0.983). It was confirmed in 30 (M=20, F=10) of cases. Failure to pass meconium was found in 21(70%) cases. Sensitivity, specificity, PPV, and NPV were 90%, 80%, 81.8% and 88.8% respectively for transitional zone in barium enema. Sensitivity, specificity, PPV, and NPV were 76.7%, 83.3%, 78.1% and 82.1% respectively for rectosigmoid index .Sensitivity, specificity, PPV, and NPV were 46.7%, 100%, 100% and 65.2% respectively for irregular contraction detected in barium enema. Sensitivity, specificity, PPV, and NPV were 23.3%, 100%, 100% and 56.6% respectively for mucosal irregularity in barium enema. Conclusion: The most sensitive finding was transitional zone. The most specific findings were irregular contraction, mucosal irregularity, and followed by cobblestone appearance.
BRAZILIAN CONSENSUS FOR MULTIMODAL TREATMENT OF COLORECTAL LIVER METASTASES. MODULE 3: CONTROVERSIES AND UNRESECTABLE METASTASES
Authors: TORRES Orlando Jorge Martins , MARQUES Márcio Carmona , SANTOS Fabio Nasser , FARIAS Igor Correia de , COUTINHO Anelisa Kruschewsky , OLIVEIRA Cássio Virgílio Cavalcante de , KALIL Antonio Nocchi , MELLO Celso Abdon Lopes de , KRUGER Jaime Arthur Pirola , FERNANDES Gustavo dos Santos , QUIREZE JR Claudemiro , MURAD André M. , SILVA Milton José de BARROS E , ZURSTRASSEN Charles Edouard , FREITAS Helano Carioca , CRUZ Marcelo Rocha , WESCHENFELDER Rui , LINHARES Marcelo Moura , CASTRO Leonaldson dos Santos , VOLLMER Charles , DIXON Elijah , RIBEIRO Héber Salvador de Castro , COIMBRA Felipe José Fernandez
Published: October 2016

ABSTRACT In the last module of this consensus, controversial topics were discussed. Management of the disease after progression during first line chemotherapy was the first discussion. Next, the benefits of liver resection in the presence of extra-hepatic disease were debated, as soon as, the best sequence of treatment. Conversion chemotherapy in the presence of unresectable liver disease was also discussed in this module. Lastly, the approach to the unresectable disease was also discussed, focusing in the best chemotherapy regimens and hole of chemo-embolization.
IMMEDIATE COMPLICATIONS AFTER 88 HEPATECTOMIES - BRAZILIAN CONSECUTIVE SERIES
Authors: AMICO Enio Campos , ALVES José Roberto , JOÃO Samir Assi , GUIMARÃES Priscila Luana Franco Costa , MEDEIROS Joafran Alexandre Costa de , BARRETO Élio José Silveira da Silva
Published: October 2016

ABSTRACT Background: Hepatectomies have been increasingly recommended and performed in Brazil; they present great differences related to immediate complications. Aim: Assessing the immediate postoperative complications in a series of 88 open liver resections. Method: Prospective database of patients subjected to consecutive hepatectomies over nine years. The post-hepatectomy complications were categorized according to the Clavien-Dindo classification; complications presenting grade equal to or greater than 3 were considered major complications. Hepatic resections involving three or more resected liver segments were considered major hepatectomies. Results: Eighty-four patients were subjected to 88 hepatectomies, mostly were minor liver resections (50 cases, 56.8%). Most patients had malignant diseases (63 cases; 71.6%). The mean hospitalization time was 10.9 days (4-43). Overall morbidity and mortality rates were 37.5% and 6.8%, respectively. The two most common immediate general complications were intra-peritoneal collections (12.5%) and pleural effusion (12.5%). Bleeding, biliary fistula and liver failure were identified in 6.8%, 4.5% and 1.1% of the cases, respectively, among the hepatectomy-specific complications. Conclusion: The patients operated in the second half of the series showed better results, which were apparently influenced by the increased surgical expertise, by the modification of the hepatic parenchyma section method and by the increased organ preservation.
MANAGEMENT OF ACUTE SEVERE ULCERATIVE COLITIS: A CLINICAL UPDATE
Authors: SOBRADO Carlos Walter , SOBRADO Lucas Faraco
Published: October 2016

ABSTRACT Introduction: Acute severe colitis is a potentially lethal medical emergency and, even today, its treatment remains a challenge for clinicians and surgeons. Intravenous corticoid therapy, which was introduced into the therapeutic arsenal in the 1950s, continues to be the first-line treatment and, for patients who are refractory to this, the rescue therapy may consist of clinical measures or emergency colectomy. Objective: To evaluate the indications for and results from drug rescue therapy (cyclosporine, infliximab and tacrolimus), and to suggest a practical guide for clinical approaches. Methods: The literature was reviewed using the Medline/PubMed, Cochrane library and SciELO databases, and additional information from institutional websites of interest, by cross-correlating the following keywords: acute severe colitis, fulminating colitis and treatment. Results: Treatments for acute severe colitis have avoided colectomy in 60-70% of the cases, provided that they have been started early on, with multidisciplinary follow-up. Despite the adverse effects of intravenous cyclosporine, this drug has been indicated in cases of greater severity with an imminent risk of colectomy, because of its fast action, short half-life and absence of increased risk of surgical complications. Therapy using infliximab has been reserved for less severe cases and those in which immunosuppressants are being or have been used (AZA/6-MP). Indication of biological agents has recently been favored because of their ease of therapeutic use, their good short and medium-term results, the possibility of maintenance therapy and also their action as a "bridge" for immunosuppressant action (AZA/6-MP). Colectomy has been reserved for cases in which there is still no response five to seven days after rescue therapy and in cases of complications (toxic megacolon, profuse hemorrhage and perforation). Conclusion: Patients with a good response to rescue therapy who do not undergo emergency operations should be considered for maintenance therapy using azathioprine. A surgical procedure is indicated for selected cases.
UNDERSTANDING THE INTERNATIONAL CONSENSUS FOR ACUTE PANCREATITIS: CLASSIFICATION OF ATLANTA 2012
Authors: SOUZA Gleim Dias de , SOUZA Luciana Rodrigues Queiroz , CUENCA Ronaldo Máfia , JERÔNIMO Bárbara Stephane de Medeiros , SOUZA Guilherme Medeiros de , VILELA Vinícius Martins
Published: October 2016

ABSTRACT Introduction: Contrast computed tomography and magnetic resonance imaging are widely used due to its image quality and ability to study pancreatic and peripancreatic morphology. The understanding of the various subtypes of the disease and identification of possible complications requires a familiarity with the terminology, which allows effective communication between the different members of the multidisciplinary team. Aim: Demonstrate the terminology and parameters to identify the different classifications and findings of the disease based on the international consensus for acute pancreatitis ( Atlanta Classification 2012). Methods: Search and analysis of articles in the "CAPES Portal de Periódicos with headings "acute pancreatitis" and "Atlanta Review". Results: Were selected 23 articles containing radiological descriptions, management or statistical data related to pathology. Additional statistical data were obtained from Datasus and Population Census 2010. The radiological diagnostic criterion adopted was the Radiology American College system. The "acute pancreatitis - 2012 Rating: Review Atlanta classification and definitions for international consensus" tries to eliminate inconsistency and divergence from the determination of uniformity to the radiological findings, especially the terminology related to fluid collections. More broadly as "pancreatic abscess" and "phlegmon" went into disuse and the evolution of the collection of patient fluids can be described as "acute peripancreatic collections", "acute necrotic collections", "pseudocyst" and "necrosis pancreatic walled or isolated". Conclusion: Computed tomography and magnetic resonance represent the best techniques with sequential images available for diagnosis. Standardization of the terminology is critical and should improve the management of patients with multiple professionals care, risk stratification and adequate treatment.
REDES DIGITAIS: UM LOCAL DE PRODUÇÃO DE VERDADES NO CONTEMPORÂNEO?
Authors: Mozzini Camila , Hennigen Inês
Published: October 2016

RESUMO O presente artigo busca debruçar-se sobre o modo como as redes digitais vêm, atreladas a tantos sonhos e expectativas, diluindo-se discursivamente no tecido social a ponto de se constituírem enquanto um possível local de veridicção no contemporâneo. Para tal, uma série de incitamentos publicitários à conexão digital será tomada como campo de investigação empírica. O objetivo desta empreitada é problematizar certa concepção de rede que, ao contrário de teoricamente compor uma zona horizontal, abre-se à materialidade como uma instância atravessada por relações de poder e, portanto, produtora de desnivelamentos e conflitos.
JOVENS MULHERES DO ÂMBITO RURAL: GÊNERO, PROJETOS DE VIDA E TERRITÓRIO EM FOTOCOMPOSIÇÕES
Authors: Pizzinato Adolfo , Hamann Cristiano , Maracci-Cardoso João Gabriel , Cezar Marcelo Moreira
Published: October 2016

RESUMO Este artigo analisa interfaces de gênero e território como marcadores identitários presentes nas falas e produções de imagens sobre projetos de vida de jovens mulheres de zonas rurais. O processo de pesquisa contemplou narrativas de caráter autobiográfico e fotocomposições realizadas pelas participantes, em que se buscou integrar aspectos de suas trajetórias acadêmicas, projetos vitais e profissionais, escolhas de vida e demandas culturais e comunitárias que influenciam no processo de construção de seus itinerários vitais. A aproximação a este grupo, comumente à margem da produção do saber em Psicologia, permitiu compreender como tais marcadores despontam de maneira dialógica em suas narrativas, questionando as formas de manifestação relacionadas aos antagonismos normativos entre o urbano/rural, o presente/passado, e das atribuições sociais ao ser mulher/homem.
TERRITORIO Y PSICOLOGÍA SOCIAL Y COMUNITARIA, TRAYECTORIAS/IMPLICACIONES POLÍTICAS Y EPISTEMOLÓGICAS
Authors: Conti Santiago
Published: October 2016

RESUMEN "Territorio" es un concepto originado en el campo disciplinar de la Geografía, que a lo largo del siglo XX ha ido reformulándose según las distintas corrientes del pensamiento social. Es factible reconocer que en la actualidad dicho concepto ha trascendido su ámbito disciplinar y es utilizado profusamente en el campo de las ciencias sociales, en general, y en la Psicología Social y Comunitaria, en particular. Trascendiendo el encuadre disciplinar de la geografía, el presente trabajo se propone realizar un recorrido analítico para comprender las implicancias políticas y epistemológicas que supone el uso del concepto "territorio" para la Psicología Social y Comunitaria. Se sostendrá que lejos de lo que los recortes disciplinares efectúan, "territorio" es un concepto que no está ni ha estado alguna vez exento de determinados supuestos psicosociales; supuestos que desde el presente artículo serán evidenciados considerando las íntimas relaciones entre las disciplinas en cuestión.
LO COMUNITARIO EN LAS REPRESENTACIONES SOCIALES DE LA VIOLENCIA
Authors: Alba Maylen Villamañan
Published: October 2016

RESUMEN El presente artículo propone un estudio teórico de la violencia en las representaciones sociales desde la concepción de lo comunitario. Esta categoría es analizada no solo desde la noción tradicional de lo comunitario como espacio geográfico sino explicada como cualidad o vínculo social de simetría o asimetría. Para ello, se revisaron artículos clásicos sobre estas categorías así como artículos de revistas arbitradas e informes de comunidades científicas y centros de investigación, preferentemente publicadas en los últimos diez años. Se examinan los presupuestos de la teoría de las representaciones sociales, los fundamentos conceptuales sobre violencia y los postulados de lo comunitario en su devenir histórico. La violencia es analizada como objeto de representación social en tanto fragmentación de los vínculos sociales o expresión de la potencialidad de lo comunitario en tres gradaciones: lo comunitario en sí, lo comunitario para sí y la comunidad en emancipación.
A PSICOLOGIA SOCIAL DE THEODOR ADORNO NA PRODUÇÃO BRASILEIRA (1984-2015)
Authors: Câmara Rodrigo Siqueira , Franciscatti Kety Valéria Simões
Published: October 2016

RESUMO Este artigo apresenta parte de uma pesquisa que procurou iluminar uma tradição brasileira de pesquisa em Psicologia Social, alicerçada na teoria de Theodor Adorno. Seu objetivo foi identificar e discutir referências e apropriações dessa teoria, em especial sua proposta para a Psicologia Social, por pesquisadores brasileiros entre 1984 e 2015. Através da análise da produção científica, foram encontrados 197 artigos, dos quais foi realizada uma análise temática de 87, caracterizados como da Psicologia, com base nas seguintes categorias: estudos sobre dominação e violência social (24); estudos sobre o indivíduo e a formação cultural (14); estudos sobre indústria cultural, propaganda e consumo (11); estudos sobre ciência, metodologia e debates teóricos (17); estudos sobre educação (13); e estudos sobre arte e estética (8). Os resultados indicam uma presença significativa e crescente dessa perspectiva em Psicologia Social no Brasil e a ampliação, por parte dos pesquisadores, do seu escopo de reflexão e atuação.
NOTAS SOBRE UM RECOMEÇO: REVISTA PSICOLOGIA & SOCIEDADE (1996 - 2001)
Authors: Alves Cecilia Pescatore , Crochík José Leon
Published: October 2016

RESUMO O presente artigo tem o objetivo de destacar dados e princípios subjacentes à política editorial da revista Psicologia & Sociedade no período entre 1996 e 2001. A análise foi realizada no sentido de indicar a coerência das diretrizes e finalidades da Associação Brasileira de Psicologia Social (ABRAPSO) com a política editorial assumida nesse período. A reflexão possibilitou identificar que a política editorial daquele período buscou a concretude do compromisso firmado na fundação da entidade. Comprometida com a realidade brasileira, a política editorial se manifestou marcada pelo caráter interdisciplinar na busca do saber, pelas relações democráticas na produção do conhecimento, pela crítica ao preestabelecido e hegemônico nas relações cotidianas, assim como, pelo desafio diante da necessidade de assumir posições contrárias às imposições mercantilistas na produção do conhecimento.
Interobserver reproducibility of radiographic evaluation of lumbar spine instability
Authors: Segundo Saulo de Tarso de Sá Pereira , Valesin Filho Edgar Santiago , Lenza Mario , Santos Durval do Carmo Barros , Rosemberg Laercio Alberto , Ferretti Mario
Published: October 2016

ABSTRACT Objective: To measure the interobserver reproducibility of the radiographic evaluation of lumbar spine instability. Methods: Measurements of the dynamic radiographs of the lumbar spine in lateral view were performed, evaluating the anterior translation and the angulation among the vertebral bodies. The tests were evaluated at workstations of the organization, through the Carestream Health Vue RIS (PACS), version 11.0.12.14 Inc. 2009© system. Results: Agreement in detecting cases of radiographic instability among the observers varied from 88.1 to 94.4%, and the agreement coefficients AC1 were all above 0.8, indicating excellent agreement. Conclusion: The interobserver analysis performed among orthopedic surgeons with different levels of training in dynamic radiographs of the spine obtained high reproducibility and agreement. However, some factors, such as the manual method of measurement and the presence of vertebral osteophytes, might have generated a few less accurate results in this comparative evaluation of measurements.
Technical advances in flow cytometry-based diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria
Authors: Correia Rodolfo Patussi , Bento Laiz Cameirão , Bortolucci Ana Carolina Apelle , Alexandre Anderson Marega , Vaz Andressa da Costa , Schimidell Daniela , Pedro Eduardo de Carvalho , Perin Fabricio Simões , Nozawa Sonia Tsukasa , Mendes Cláudio Ernesto Albers , Barroso Rodrigo de Souza , Bacal Nydia Strachman
Published: October 2016

ABSTRACT Objective: To discuss the implementation of technical advances in laboratory diagnosis and monitoring of paroxysmal nocturnal hemoglobinuria for validation of high-sensitivity flow cytometry protocols. Methods: A retrospective study based on analysis of laboratory data from 745 patient samples submitted to flow cytometry for diagnosis and/or monitoring of paroxysmal nocturnal hemoglobinuria. Results: Implementation of technical advances reduced test costs and improved flow cytometry resolution for paroxysmal nocturnal hemoglobinuria clone detection. Conclusion: High-sensitivity flow cytometry allowed more sensitive determination of paroxysmal nocturnal hemoglobinuria clone type and size, particularly in samples with small clones.
Preclinical molecular imaging: development of instrumentation for translational research with small laboratory animals
Authors: Mejia Jorge , Miranda Ana Claudia Camargo , Durante Ana Claudia Ranucci , Oliveira Larissa Rolim de , Barboza Marycel Rosa Felisa Figols de , Rosell Katerin Taboada , Jardim Daniele Pereira , Campos Alexandre Holthausen , Reis Marilia Alves dos , Catanoso Marcela Forli , Galvis-Alonso Orfa Yineth , Cabral Francisco Romero
Published: October 2016

ABSTRACT Objective: To present the result of upgrading a clinical gamma-camera to be used to obtain in vivo tomographic images of small animal organs, and its application to register cardiac, renal and neurological images. Methods: An updated version of the miniSPECT upgrading device was built, which is composed of mechanical, electronic and software subsystems. The device was attached to a Discovery VH (General Electric Healthcare) gamma-camera, which was retired from the clinical service and installed at the Centro de Imagem Pré-Clínica of the Hospital Israelita Albert Einstein. The combined system was characterized, determining operational parameters, such as spatial resolution, magnification, maximum acceptable target size, number of projections, and acquisition and reconstruction times. Results: Images were obtained with 0.5mm spatial resolution, with acquisition and reconstruction times between 30 and 45 minutes, using iterative reconstruction with 10 to 20 iterations and 4 projection subsets. The system was validated acquiring in vivo tomographic images of the heart, kidneys and brain of normal animals (mice and adult rats), using the radiopharmaceuticals technetium-labeled hexakis-2-methoxy-isobutyl isonitrile (99mTc-Sestamibi), technetium-labeled dimercaptosuccinic acid (99mTc-DMSA) and technetium-labeled hexamethyl propyleneamine oxime (99mTc-HMPAO). Conclusion: This kind of application, which consists in the adaptation for an alternative objective of already existing instrumentation, resulted in a low-cost infrastructure option, allowing to carry out large scale in vivo studies with enhanced quality in several areas, such as neurology, nephrology, cardiology, among others.
Randomized double-blind clinical trial comparing two anesthetic techniques for ultrasound-guided transvaginal follicular puncture
Authors: Oliveira Júnior Gilvandro Lins de , Serralheiro Fernando Cesar , Fonseca Fernando Luiz Affonso , Ribeiro Junior Onésimo Duarte , Adami Fernando , Christofolini Denise Maria , Bianco Bianca , Barbosa Caio Parente
Published: October 2016

ABSTRACT Objective: To compare the anesthetic techniques using propofol and fentanyl versus midazolam and remifentanil associated with a paracervical block with lidocaine in performing ultrasound-guided transvaginal oocyte aspiration. Methods: A randomized double-blind clinical trial (#RBR-8kqqxh) performed in 61 women submitted to assisted reproductive treatment. The patients were divided into two groups: anesthetic induction with 1mcg/kg of fentanyl associated with 1.5mg/kg of propofol (FP Group, n=32), in comparison with anesthetic induction using 0.075mg/kg of midazolam associated with 0.25mcg/kg/min of remifentanil, and paracervical block with 3mL of 2% lidocaine (MRPB Group, n=29). Main outcome measures: human reproduction outcomes, modified Aldrete-Kroulik index, hemodynamic parameters, and salivary cortisol. Results: The results revealed a higher number of embryos formed in the FP Group (p50=2 versus 1; p=0.025), gestation rate two times higher in the FP Group (44.4% versus 22.2%; p=0.127), less time to reach AK=10 in the MRPB Group (p50=10 versus 2; p<0.001), and lower mean of hemodynamic parameters in the MRPB Group (p<0.05). Conclusion: Anesthesia with fentanyl and propofol as well as with midazolam, remifentanil, and paracervical block offered satisfactory anesthetic conditions when performing assisted reproduction procedures, providing comfort for the patient and physician.
Multiparametric magnetic resonance imaging findings of prostatic pure leiomyomas
Authors: Mussi Thais Caldara , Costa Yves Bohrer , Obara Marcos Takeo , Queiroz Marcos Roberto Gomes de , Garcia Rodrigo Gobbo , Longo José Antonio Domingos Cianciarulo , Lemos Gustavo Caserta , Baroni Ronaldo Hueb
Published: October 2016

ABSTRACT Objective: To describe the imaging findings of prostatic tumors nonadenocarcinoma on multiparametric magnetic resonance imaging. Methods: A total of 200 patients underwented multiparametric magnetic resonance imaging of the prostate for screening for prostate cancer, from August 2013 to September 2014, followed by biopsy with ultrasound/magnetic resonance imaging fusion. Results: We found three pathologic proved cases of prostatic pure leiomyomas (0.02%) in our series and described the multiparametric magnetic resonance imaging features of these prostatic leiomyomas. The imaging findings had similar features to lesions with moderate or high suspicion for significant cancer (Likert 4 or 5) when localized both in the transitional zone or in the peripheral zone of the gland. Conclusion: Pure prostatic leiomyomas had imaging findings on multiparametric magnetic resonance imaging that mimicked usual adenocarcinomas on this test. Radiologists, urologists and pathologists must be aware of this entity and its imaging features.
Association of gestational age with the option of pregnancy termination for fetal abnormalities incompatible with neonatal survival
Authors: Westphal Flavia , Fustinoni Suzete Maria , Pinto Vânia Lopes , Melo Patrícia de Souza , Abrahão Anelise Riedel
Published: October 2016

ABSTRACT Objective: To identify the profile of women seen in a Fetal Medicine unit, diagnosed with fetal abnormality incompatible with neonatal survival in their current pregnancy, and to check the association of gestational age upon diagnosis with the option of pregnancy termination. Methods: This is a retrospective cohort study carried out in the Fetal Medicine Outpatients Clinic of a university hospital, in the city of São Paulo (SP), Brazil, using medical records of pregnant women with fetus presenting abnormalities incompatible with neonatal survival. The sample comprised 94 medical records. The Statistical Package for the Social Sciences (SPSS), version 19, was used for the data statistical analysis. Results: The population of the study included young adult women, who had complete or incomplete high school education, employed, with family income of one to three minimum wages, single, nonsmokers, who did not drink alcoholic beverages or used illicit drugs. Women with more advanced gestational age upon fetal diagnosis (p=0.0066) and/or upon admission to the specialized unit (p=0.0018) presented a lower percentage of termination of pregnancy. Conclusion: Due to characteristics different from those classically considered as of high gestational risk, these women might not be easily identified during the classification of gestational risk, what may contribute to a late diagnosis of fetal diseases. Early diagnosis enables access to specialized multiprofessional care in the proper time for couple's counseling on the possibility of requesting legal authorization for pregnancy termination.
Disparities in cancer epidemiology and care delivery among Brazilian indigenous populations
Authors: Aguiar Jr. Pedro Nazareth , Stock Gustavo Trautman , Lopes Jr. Gilberto de Lima , Almeida Michelle Samora de , Tadokoro Hakaru , Gutierres Bárbara de Souza , Rodrigues Douglas Antônio
Published: October 2016

ABSTRACT Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included. The cancer incidence was 15.73 per 100,000. The mean age at diagnosis was 54 years and most patients were female (58%). Cancer of the cervix (28%) and prostate (16%) were the most common. The mean time between the onset of symptoms and the diagnosis was 9 months and from diagnosis to the treatment was 3.4 months. Disease diagnosed at stage IV (17%) had worse overall survival (HR: 11.4; p<0.05). The 5-year survival rate ranged from 88% for prostate cancer to 0% for lung cancer. All 5-year survival rates were lower as compared to other populations. Conclusion: The most prevalent cancer sites were cervix and prostate. Disease stage and primary site were prognostic factors.
The good pharmacy practice on Einstein Program at Paraisópolis Community
Authors: Oliveira Lara Tânia de Assumpção Domingues Gonçalves de , Silva Camila Pontes da , Guedes Maria das Vitorias , Sousa Ana Célia de Oliveira , Sarno Flávio
Published: October 2016

ABSTRACT Objectives: To describe indicators and processes developed and implemented for pharmaceutical assistance at the Einstein Program at Paraisópolis Community pharmacy. Methods: This was a descriptive study of retrospective data from January 2012 to December 2015. Data were obtained from spreadsheets developed for monitoring the productivity and care quality provided at the pharmacy. The evaluated variables were pharmaceutical assistance to prescription, pharmaceutical intervention, orientation (standard and pharmaceutical) and pharmaceutical orientation rate. Results: The pharmacy assisted, on average, 2,308 prescriptions monthly, dispensing 4,871 items, including medications, materials and food supplements. Since March 2015, virtually, the pharmacist analyzed all prescriptions, prior to dispensing. In the analyzed period, there was an increase in monthly pharmaceutical interventions from 7 to 32 on average, and, although there was a decrease in the number of standard orientation, the pharmaceutical orientation had an increase, causing a rise of pharmaceutical orientation rate from 4 to 11%. Conclusion: The processes developed and implemented at the program pharmacy sought to follow the good pharmacy practice, and help patients to make the best use of their medications.
Phase II Trial of Abiraterone Acetate Plus Prednisone in Black Men With Metastatic Prostate Cancer
Authors: Tsao Che-Kai , Sfakianos John , Liaw Bobby , Gimpel-Tetra Kiev , Kemeny Margaret , Bulone Linda , Shahin Mohammad , Oh William Kyu , Galsky Matthew David
Published: October 2016

Lessons Learned

The safety and activity findings of abiraterone acetate plus prednisone treatment in black men with mCRPC were similar to results from previously conducted studies with largely white populations. Poor trial accrual continues to be a challenge in black men with mCRPC and further efforts are needed to address such underrepresentation.

Background.

Self-identified black men have higher incidence and mortality from prostate cancer in the United States compared with white men but are dramatically underrepresented in clinical trials exploring novel therapies for metastatic castration-resistant prostate cancer (mCRPC).

Methods.

Black men with mCRPC were treated with abiraterone acetate (AA), 1,000 mg daily, and prednisone (P), 5 mg twice daily. The primary objective was to determine antitumor activity (defined by a ≥30% decline in prostate-specific antigen [PSA] level) and to correlate germline polymorphisms in androgen metabolism genes with antitumor activity. Secondary objectives included determining safety, post-treatment changes in measurable disease, and time to disease progression.

Results.

From April 2013 to March 2016, a total of 11 black men were enrolled and received AA plus P (AA+P); 7 of 10 evaluable patients were docetaxel naive. Post-treatment declines in PSA level of ≥30% were achieved in 90% of patients. The side effect profile was consistent with prior clinical trials exploring AA+P in mCRPC. Due to poor accrual, the study was closed prematurely with insufficient sample size for the planned pharmacogenetic analyses.

Conclusion.

In this small prospective study terminated for poor accrual, the safety and activity of AA+P in black men with mCRPC was similar to that reported in prior studies exploring AA in largely white populations. Further efforts are needed to address underrepresentation of black men in mCRPC trials.
Survival Outcomes in Asymptomatic Patients With Normal Conventional Imaging but Raised Carcinoembryonic Antigen Levels in Colorectal Cancer Following Positron Emission Tomography-Computed Tomography Imaging
Authors: Khan Khurum , Athauda Avani , Aitken Katharine , Cunningham David , Watkins David , Starling Naureen , Cook Gary J. , Kalaitzaki Eleftheria , Chau Ian , Rao Sheela
Published: October 2016

Background.

This study had two aims: (a) to evaluate the utility of fluorine 18-fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) in detecting occult disease recurrence with raised carcinoembryonic antigen (CEA) and (b) to establish the prognostic effects of early detection of disease recurrence in patients with colorectal cancer (CRC).

Patients and Methods.

Clinico-pathological data were obtained from all consecutive patients undergoing CRC surveillance from 2004 to 2010 who had an elevated CEA level (>3 ng/mL in nonsmokers, >5 ng/mL in smokers) but normal or equivocal conventional investigations. Histopathological confirmation or a minimum of 12 months’ clinical and radiological follow-up were required to ascertain disease relapse.

Results.

A total of 1,200 patients were screened; of those, 88 (59% men; mean age, 66 years [SD, 9.6]) eligible patients (67 with normal and 21 with equivocal results on conventional investigations) were identified. Recurrent disease was detected in 56 of 88 patients (64%). The sensitivity of FDG PET-CT to detect recurrence was 49 of 56 (88%; 95% confidence interval [CI], 76%–95%) and specificity was 28 of 32 (88%; 95% CI, 71%–97%). Twenty-seven of 49 (55%) patients with PET-CT-detected relapsed disease were deemed eligible for further curative therapy; 19 (70%) went on to receive potentially curative therapy. The median time to progression (8.8 months [interquartile range (IQR), 4.5–19.1 months] vs. 2.2 months [IQR, 0.7–5.6]), median overall survival (39.9 months [IQR, 23.6–65.4 months] vs. 15.6 months [IQR, 7.3–25.7 months]), and 5-year survival (36.8% [95% CI, 16.5%–57.5%] vs. 6.1% [95% CI, 1.1%–17.6%]; p ≤ .001) were higher in patients who received potentially curative therapy than in those who received noncurative therapy.

Conclusion.

FDG PET-CT is a highly sensitive and specific tool for the detection of occult CRC recurrence. In >50% of patients, recurrent disease may still be potentially amenable to curative therapy. Long-term survival can be achieved in such patients.
The founding story of «SULAMOT Group»: from parental experience to professional help to children with ASD
Authors: Slepyan M.
Published: October 2016

Famous Israeli multi-disciplinary center for learning disabilities and ASD treatment «SULAMOT Group» was founded by two friends, as one of them faced with the problem of autism in her own son. Both acquired new education and wide knowledge about autism. It helped in the organization of specialized treatment for children with autism spectrum disorders, not only from Israel but also from other countries with Russian-speaking population
Sharp resonant focusing of light by a dielectric cylinder with square cross-section and cube
Authors:   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS, Kozlov D. ,   Samara National Research University, Kozlova E. ,   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University, Kotlyar V. ,   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University
Published: October 2016

In this paper a research on conditions for resonance excitation in a homogeneous dielectric cylinder with square cross-section is conducted using a FDTD-method. It is shown that in a cylinder with square cross-section resonant modes similar to whispering gallery modes can be excited, which allows one to reduce the transverse dimensions of the focal spot. FDTD method demonstrates an acceptable accuracy of the resonant mode detection. A similar result is obtained for a cube on a dielectric substrate: it is possible to achieve the reduction of the transverse dimensions of the focal spot by changing the corresponding cube size.
Solving the inverse problem of focusing laser radiation in a plane region using geometrical optics
Authors:   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS, Kharitonov S. ,   Samara National Research University, Doskolovich L. ,   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University, Kazanskiy N. ,   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University
Published: October 2016

We proposed a method for calculating the eikonal function of a light field from the condition of generating a desired intensity distribution in a predetermined region of the focal plane. To improve the efficiency of solving the problem of focusing we developed a modification of a method of rectangle matching, which enables designing diffractive optical elements (DOE) intended to focus into a plane region. The novelty of our approach consists in a method of reconstructing the eikonal function from the known ray map of points on the DOE onto points in the focal plane. We presented the results of the DOE-aided focusing into a circle, a rectangle, a rhombus, and a superellipse. The simulation results showed the high quality of focusing, thus corroborating the efficiency of the proposed method. We expect to use the diffractive optical elements (DOE) for lighting the area of interest from low-flying drones used for night-time Earth remote sensing.
Subwavelength focusing of laser light of a mixture of linearly and azimuthally polarized beams
Authors:   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS, Stafeev S. ,   Samara National Research University, Nalimov A. ,   Image Processing Systems Institute оf RAS, – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University, Kotlyar M. ,   Samara National Research University, O’Faolain L. ,   School of Physics and Astronomy of the University of St. Andrews
Published: October 2016

We investigated a four-zone transmission polarization converter (4-TPC) for a wavelength of 633 nm, enabling the conversion of a linearly polarized incident beam into a mixture of linearly and azimuthally polarized beams. It was numerically shown that by placing a Fresnel zone plate of focal length 532 nm immediately after the 4-TPC, the incident light can be focused into an oblong subwavelength focal spot whose size is smaller than the diffraction limit (with larger and smaller size, respectively, measuring FWHM = 0.28λ and FWHM = 0.45λ, where λ is the incident wavelength and FWHM stands for full-width at half maximum of the intensity). If after passing through a 4-TPC, light propagates in free space over a distance of 300 um before being focused by a Fresnel zone plate, the resulting focal spot was found to measure 0.42λ and 0.81λ (with the focal spot contributed to just by the transverse E-field components measuring 0.42λ and 0.59λ). This numerical result was verified experimentally, giving a focal spot of smaller and larger size, respectively, measuring 0.46λ and 0.57λ.
Measuring the thickness of Z-cut uniaxial crystals based on Bessel laser beams
Authors:   Samara National Research University, Paranin V.
Published: October 2016

An optical method for measuring the thickness of z-cut uniaxial crystals is proposed. The method uses a periodic mutual conversion of zero- and second-order Bessel beams observed during their propagation along the optical axis of a uniaxial crystal. The paper presents the theoretical background and features of the practical implementation of the measuring method. The applicability of the method for measuring thicknesses ranging from tens of micrometers up to tens of millimeters is shown for a lithium niobate crystal.
Transformacja polskiej polityki społecznej a członkostwo w Unii Europejskiej
Authors: Prorok Lucyna
Published: October 2016

Polska polityka społeczna została ukształtowana na gruncie głębokich zmian systemowych, jakie dokonały się w kraju na początku lat 90. XX w. Pogłębiający się kryzys polityczny i ekonomiczny, otwarty konflikt społeczny doprowadził do załamania się ustroju i rozpoczęcia przekształceń w formie transformacji systemowej. Przejście od socjalistycznego systemu gospodarowania, opartego na własności państwa oraz centralnym planowaniu i zarządzaniu gospodarką, do kapitalistycznego systemu rynkowego spowodowało radykalne zmiany we wszystkich strukturach państwa. Konieczna była reorganizacja polityczna, ekonomiczna i społeczna kraju na poziomie: zarządzania instytucjami, organizacji zasad działania gospodarki, a także relacji wewnątrzspołecznych. Natomiast okres akcesyjny przed członkostwem w Unii Europejskiej to transformacja, mająca na celu: ekonomiczne ustabilizowanie gospodarki krajowej, dokonanie przekształceń w sferze prawno-instytucjonalnej oraz nawiązanie współpracy ekonomicznej i politycznej z państwami Europy Zachodniej. Kumulacja różnych politycznych, ekonomicznych i społecznych czynników zdeterminowała kierunek procesu transformacyjnego i modernizacyjnego w Polsce przełomu wieków, ale także ukształtowała nowe przesłanki konceptualizowania zadań i celów polityki społecznej. A zatem pytanie brzmi: w jakim stopniu kolejne procesy modernizacyjne zmieniły politykę społeczną, realizowaną w Polsce, w czasie odchodzenia od modelu socjalistycznego i dochodzenia do Europejskiego Modelu Społecznego?
Praca w doświadczeniu biograficznym trzech generacji kobiet z łódzkich enklaw biedy
Authors: Potoczna Małgorzata
Published: October 2016

Łódź nazywana jest miastem pracujących kobiet. Przez ponad dwieście lat rozwój miasta, losy życiowe i sytuacja zawodowa jej mieszkańców były związane z funkcjonowaniem zakładów przemysłu tekstylnego, włókienniczego, odzieżowego, które oferowały zatrudnienie przede wszystkim kobietom1. Artykuł traktuje o znaczeniu pracy zarobkowej w generowaniu sytuacji życiowej trzech generacji łódzkich kobiet. Wskazuje znaczącą rolę, jaką w przełamywaniu lub ześlizgiwaniu się w biedę mieszkanek przemysłowej Łodzi odegrały – determinowane przez wydarzenia historyczne (II wojna światowa), a przede wszystkim procesy społeczno-ekonomiczne (dekoniunktura gospodarcza lat międzywojennych, powojenna transformacja ustrojowa i transformacja systemowa lat 90.) – zmiany zachodzące na łódzkim rynku pracy. W doświadczeniu starszej generacji mieszkanek Łodzi powojenna transformacja ustrojowa, w głównej mierze procesy intensywnej industrializacji i nacjonalizacji przemysłu, gwarantując szeroki dostęp do pracy zawodowej, otworzyły wykorzystaną przez wiele z nich szansę wyjścia z biedy, doświadczanej w okresie międzywojennym, w rodzinach pochodzenia. Dla pokolenia ich córek, które wkroczyły w życie dorosłe na przełomie lat 70. i 80., podejmując podobnie jak matki bez większych problemów pracę zawodową, stanowi ona szansę na utrzymanie względnie stabilnej sytuacji materialnej w kolejnym pokoleniu. Sytuację życiową kobiet średniej generacji oraz kolejnej, młodszej, w znaczący sposób zmienia zapoczątkowany w latach 90. proces restrukturyzacji łódzkiego przemysłu włókienniczego. W efekcie tych zmian kobiety średniej i młodszej generacji tracą możliwość utrzymania pracy, młodszej – podjęcia pracy zawodowej w ogóle, obie generacje zasilają w ten sposób kategorię osób zbędnych na rynku pracy.
Aktywizowanie przez sport jako sposób inkluzji oraz integracji społecznej osób niepełnosprawnych
Authors: Niedbalski Jakub
Published: October 2016

Celem artykułu jest pokazanie, jak na tle istniejących uwarunkowań społecznych oraz instytucjonalnych realizowana jest koncepcja integracji i inkluzji społecznej osób niepełnosprawnych, w której najważniejsze miejsce zajmuje aktywność sportowa. W badaniach przeprowadzonych wśród osób niepełnosprawnych, uprawiających sport, wykorzystane zostały dane jakościowe, zdobyte za pomocą techniki pogłębionego wywiadu swobodnego oraz obserwacji jawnej. Analiza i interpretacja materiałów empirycznych prowadzona była zgodnie z zasadami metodologii teorii ugruntowanej. Przeprowadzone badania dowiodły, że sport uprawiany przez osoby niepełnosprawne może wspomóc proces włączania osób niepełnosprawnych w szersze kręgi społeczne. Sport stanowi bowiem nie tylko szansę utrzymania sprawności fizycznej i zdrowia, lecz także wspomaga integrację i inkluzję społeczną osób niepełnosprawnych.