bluuebunny/crossref_metadata_2025 huggingface dataset:
Case Report: Occlusion of the foramen of Monro treated with endoscopic septostomy and foraminotomy in a preterm neonate
Authors: Lai Po-Yu , Li Cheng-Hao , Yang Ming-Tao , Feng Pao-Hui , Kuok Chi-Man
Published: December 2023

Background

Hydrocephalus is a brain abnormality frequently encountered in neonates. There are several known etiologies of hydrocephalus, which can be classified as either congenital or acquired. Occlusion of the foramen of Monro (FOM) is a cause of hydrocephalus and can be either congenital or secondary to various disorders. Idiopathic obstruction of the FOM presenting as prenatal ventriculomegaly is extremely rare but has been reported.

Case presentation

We present the case of a preterm newborn with severe bilateral hydrocephalus due to FOM occlusion in the prenatal period. Although the neonate had normal head circumference and no clinical symptoms after birth, brain sonography revealed progressive ventriculomegaly. Further image revealed bilateral ventriculomegaly with normal-sized third and fourth ventricles. We suspected a complete obstruction of the right and a partial obstruction of the left of the FOM. The neonate underwent endoscopic septostomy and foraminotomy, resulting in improvement.

Conclusion

We report a case of preterm FOM occlusion in the youngest and smallest neonate to date. Endoscopic septostomy and foraminotomy were performed in order to avoid ventriculoperitoneal shunt-related complications, highlighting the viability of endoscopic procedures which should be the primary treatment in preterm neonates with FOM occlusion.
Isavuconazole for Treating Invasive Mould Disease in Solid Organ Transplant Recipients
Authors: Silva Jose Tiago , Husain Shahid , Aguado José María
Published: December 2023

Solid organ transplant (SOT) recipients have a higher risk of developing invasive mould diseases (IMD). Isavuconazole is a novel broad-spectrum azole active against Aspergillus spp. and Mucor, well tolerated, with an excellent bioavailability and predictable pharmacokinetics, that penetrates in most tissues rapidly, and has few serious adverse effects, including hepatic toxicity. Contrary to other broad-spectrum azoles, such as voriconazole and posaconazole, isavuconazole appears to show significant smaller drug-drug interactions with anticalcineurin drugs. We have performed an extensive literature review of the experience with the use of isavuconazole in SOT, which included the SOTIS and the ISASOT studies, and published case reports. More than 140 SOT recipients treated with isavuconazole for IMD were included. Most patients were lung and kidney recipients treated for an Aspergillus infection. Isavuconazole was well tolerated (less than 10% of patients required treatment discontinuation). The clinical responses appeared comparable to that found in other high-risk patient populations. Drug-drug interactions with immunosuppressive agents were manageable after the reduction of tacrolimus and the adjustment of mTOR inhibitors at the beginning of treatment. In conclusion, isavuconazole appears to be a reasonable option for the treatment of IMD in SOT. More clinical studies are warranted.
New Insights into Polymorphisms in Candidate Genes Associated with Incidence of Postparturient Endometritis in Ossimi Sheep (Ovis aries)
Authors: Safhi Fatmah A. , Ateya Ahmed
Published: December 2023

This study examined the genes related to immunity, metabolism, and antioxidants that may interact with the prevalence of postpartum endometritis in Ossimi sheep. We used fifty endometritis-positive Ossimi sheep and fifty that appeared to be normal. For the purpose of taking blood samples, each ewe had its jugular vein pierced. Nucleotide sequence differences for the immunological (alpha-2-macroglobulin, toll-like receptor 2, transforming growth factor beta, interleukin 1 receptor-associated kinase 3, high-mobility group box 1, Fc alpha and Mu receptor, and inducible nitric oxide synthase), metabolic (ADAM metallopeptidase with thrombospondin type 1 motif 20, potassium sodium-activated channel subfamily T member 2, Mitogen-activated protein kinase kinase kinase 4, FKBP prolyl isomerase 5, and relaxin family peptide receptor 1), and antioxidant (superoxide dismutase, catalase, NADH: ubiquinone oxidoreductase subunit s5, and Heme oxygenase-1) genes were found among sheep with endometritis and those in good condition utilizing PCR-DNA sequencing. Fisher’s exact test revealed a significant difference in the probability of dispersal of all significant nucleotide changes between ewe groups with and without endometritis (p ˂ 0.01). In endometritis ewes, there was a considerable up-regulation of the expression levels of A2M, TLR2, IRAK3, HMGB1, FCAMR, iNOS, ADAMTS20, KCNT2, MAP3K4, FKBP5, RXFP1, and HMOX1. Conversely, there was a down-regulation of the genes that encode TGF-β, SOD, CAT, and NDUFS5. The kind of marker and its frequency in postparturient endometrtits significantly impacted the transcript levels of the indicators under analysis. The results validate that nucleotide changes and gene manifestation outlines in these candidates are significant predictors of the prevalence of endometritis in sheep.
Development, Validation, and Application of Building Energy Simulation Models for Livestock Houses: A Systematic Review
Authors: Costantino Andrea
Published: December 2023

The need to improve the sustainability of intensive livestock farming has led to an increasing adoption of Building Energy Simulation (BES) models for livestock houses. However, a consolidated body of knowledge specifically dedicated to these models is lacking in literature. This gap represents a significant obstacle to their widespread application and scalability in research and industry. The aim of this work is to pave the way for scaling the adoption of BES models for livestock houses by providing a comprehensive analysis of their application, development, and validation. For this aim, a systematic review of 42 papers—selected from over 795 results from the initial database query—is carried out. The findings underscored a growing body of research that involves BES models for different purposes. However, a common approach in both model development and validation is still lacking. This issue could hinder their scalability as a standard practice, especially in industry, also considering the limitations of BES models highlighted in this work. This review could represent a solid background for future research since provides an up-to-date framework on BES models for livestock houses and identifies future research opportunities. Moreover, it contributes to increasing the reliability of BES models for livestock houses by providing some recommendations for their validation.
Co-Composting of Hop Bines and Wood-Based Biochar: Effects on Composting and Plant Growth in Copper-Contaminated Soils
Authors: Görl Johannes , Lohr Dieter , Meinken Elke , Hülsbergen Kurt-Jürgen
Published: December 2023

Decades of intensive use of copper-based fungicides against downy mildew in hops has led to considerable accumulation of copper in topsoil, resulting in toxic effects on plants. Due to its high sorption capacity, the application of co-composted biochar compost might reduce copper toxicity, whereby a synergistic effect of the composting process is supposed to occur. Furthermore, biochar addition might improve the composting process itself. Therefore, hop bines were co-composted without as well as with 5 and 20 vol% biochar, respectively. During composting, the temperature and concentration of O2, CO2, H2S, CH4 and NH3 in the compost heaps were regularly recorded. The biochar-free compost as well as the two composts with the biochar addition were characterized with regard to their plant-growing properties and were mixed into soils artificially spiked with different amounts of copper as well as into copper-polluted hop garden and apple orchard soils. The respective soil without the compost addition was used as the control, and further treatments with biochar alone and in combination with biochar-free compost were included in a plant response test with Chinese cabbage. The biochar addition increased the temperature within the compost heaps by about 30 °C and extended the duration of the thermophilic phase by almost 30 days, resulting in a higher degree of hygienization. Furthermore, the application of co-composted biochar composts significantly improved plant biomass by up to 148% and reduced the copper concentration, especially of roots, by up to 35%. However, no significant differences in the biochar-free compost were found in the artificially copper-spiked soils, and the effect of co-composted biochar compost did not differ from the effect of biochar alone and in combination with biochar-free compost. Nevertheless, the co-composting of hop bines with biochar is recommended to benefit from the positive side effect of improved sanitization in addition to reducing copper toxicity.
Rice Straw Mulch Installation in a Vineyard Improves Weed Control and Modifies Soil Characteristics
Authors: Gómez de Barreda Diego , Bautista Inmaculada , Castell Vicente , Lidón Antonio
Published: December 2023

After harvesting rice paddy fields, rice straw is a significant problem due to uncontrolled CO2 emissions when the straw is burned. One solution to this problem is to use this rice by-product for mulching planting lines of fruit trees or vineyards with the purpose of controlling weeds and improving soil characteristics. A 3-year experiment was conducted at the Polytechnic University of Valencia (Spain) demonstration vineyard, where rice-straw mulch was installed at three rates in 2021, 24.0, 43.1, and 63.1 t ha−1, and in 2022, 25.0, 37.5, and 50.0 t ha−1. Weeds were mainly controlled with the highest treatment rate (50.0–63.1 t ha−1), as the time of the year for mulch installation is decisive for achieving different weed control rates. On average, mulch decreased soil bulk density (5.4%), and increased the soil organic carbon (24.3%) and water-soluble organic carbon (24.3%) compared to bare soil. Soil temperature changes were observed due to the mulch treatment, with soil temperature lower in bare soil than in mulched soil during the cold season, and higher during the warm season. This effect was highly dependent on the mulch application rate. Soil moisture content was also higher under the mulch treatment, showing a mulch-rate response during the four seasons of the year. The changes in the physical and biological soil properties induced a higher soil respiration rate when mulched soil was compared to bare soil. This study concludes that the use of rice straw as a mulch had positive effects on weed control and soil properties, although three factors concerning mulch management were paramount: rate, the timing of installation, and replacement rate.
Potato Leaf Chlorophyll Content Estimation through Radiative Transfer Modeling and Active Learning
Authors: Ma Yuanyuan , Qiu Chunxia , Zhang Jie , Pan Di , Zheng Chunkai , Sun Heguang , Feng Haikuan , Song Xiaoyu
Published: December 2023

Leaf chlorophyll content (LCC) significantly correlates with crop growth conditions, nitrogen content, yield, etc. It is a crucial indicator for elucidating the senescence process of plants and can reflect their growth and nutrition status. This study was carried out based on a potato nitrogen and potassium fertilizer gradient experiment in the year 2022 at Keshan Farm, Qiqihar Branch of Heilongjiang Agricultural Reclamation Bureau. Leaf hyperspectral and leaf chlorophyll content data were collected at the potato tuber formation, tuber growth, and starch accumulation periods. The PROSPECT-4 radiative transfer model was employed to construct a look-up table (LUT) as a simulated data set. This was accomplished by simulating potato leaves’ spectral reflectance and chlorophyll content. Then, the active learning (AL) technique was used to select the most enlightening training samples from the LUT based on the measured potato data. The Gaussian process regression (GPR) algorithm was finally employed to construct the inversion models for the chlorophyll content of potato leaves for both the whole and single growth periods based on the training samples selected by the AL method and the ground measured data of the potatoes. The R2 values of model validation accuracy for the potato whole plantation period and three single growth periods are 0.742, 0.683, 0.828, and 0.533, respectively with RMSE values of 4.207, 4.364, 2.301, and 3.791 µg/cm2. Compared with the LCC inversion accuracy through LUT with a cost function, the validation accuracies of the GPR_PROSPECT-AL hybrid model were improved by 0.119, 0.200, 0.328, and 0.255, and the RMSE were reduced by 3.763, 2.759, 0.118, and 5.058 µg/cm2, respectively. The study results indicate that the hybrid method combined with the radiative transfer model and active learning can effectively select informative training samples from a data pool and improve the accuracy of potato LCC estimation, which provides a valid tool for accurately monitoring crop growth and growth health.
The Defensive Behaviors and Milk Production of Pastured Dairy Cattle in Response to Stable Flies, Horn Flies, and Face Flies
Authors: Hansen Anna C. , Moon Roger D. , Endres Marcia I. , Pereira Glenda M. , Heins Bradley J.
Published: December 2023

Thirty-four crossbred dairy cows were observed on pasture six times per week from June to August 2014 at the University of Minnesota West Central Research and Outreach Center grazing dairy in Morris, MN, for defensive behaviors in response to three species of muscid flies. Counts of stable flies (Stomoxys calcitrans (L.)), horn flies (Haematobia irritans (L.)), and face flies (Musca autumnalis DeGeer) were recorded before and after pasture observation. Individual cows were monitored for 5 min intervals to observe the frequencies of five different defensive behaviors: front and back leg stomps, head tosses, skin twitches, and tail swishes. Fly numbers averaged 5 stable flies per leg, 37 horn flies per side, and 1 face fly per face during the study. The fly counts and behavior frequencies increased with ambient temperature. The results showed a very strong relationship between the numbers of flies and numbers of defensive behaviors, though correlations between specific flies and behaviors were low. Younger cows had fewer stable flies and horn flies than older cows. The thresholds of flies to lower production for pastured organic dairy cows may be greater than 5 for stable flies, 37 for horn flies, and 1 for face flies.
Effects of Feeding Corn Distillers Dried Grains with Solubles on Muscle Quality Traits and Lipidomics Profiling of Finishing Pigs
Authors: Ma Zhizhuo , Wang Chunsheng , Wang Bo , Yao Linfang , Kong Baohua , Shan Anshan , Li Jianping , Meng Qingwei
Published: December 2023

This study investigated the effects of adding corn distillers dried grains with solubles (DDGS) to the diet on the meat quality, chemical composition, fatty acid composition, and lipidomics profiling in the longissimus thoracis (LT) of finishing pigs. Twenty-four healthy crossbred pigs (average body weight 61.23 ± 3.25 kg) were randomly divided into two groups with three replicates per group and four pigs per pen. The control group (CON) was fed a basal diet, and the DDGS group was fed an experimental diet with 30% DDGS. The results show that adding DDGS to the diet increases the yellowness (b*), chroma (C*), linoleic acid (C18:2n-6) percentages, polyunsaturated fatty acid (PUFA) percentages and iodine value of LT (p < 0.05). Based on LC–ESI–MS/MS, 1456 lipids from 6 classes or 44 subclasses in LT were analyzed, and 50 differential lipids were observed. Triglyceride (TG) with C18:2n-6 side chains and ceramide alpha-hydroxy fatty acid-sphingosine (Cer–AS) contents increased significantly, and the decrease in multiple glycerophospholipids (GPs) content may be related to differences in the glycerophospholipid metabolic pathway. Correlation analysis suggests that triglycerides with C18:2n-6 side chains may be one of the reasons for the changes in b* and C* values in the LT. In conclusion, feeding DDGS affects the meat quality and fatty acid composition and may affect the lipid profile in the LT of finishing pigs by regulating lipid metabolism.
Differences in Levels of Mitochondrial DNA Content at Various Stages of Canine Myxomatous Mitral Valve Disease
Authors: Chirathanaphirom Suphakan , Chuammitri Phongsakorn , Pongkan Wanpitak , Manachai Nawin , Chantawong Pinkarn , Boonsri Burin , Boonyapakorn Chavalit
Published: December 2023

Myxomatous mitral valve disease (MMVD) is the most common heart disease in small-breed dogs, often leading to heart failure. Oxidative stress in MMVD can harm mitochondria, decreasing their DNA content. This study assesses dogs’ oxidative stress and mitochondrial DNA at different MMVD stages. Fifty-five small-breed dogs were categorized into four groups, including: A—healthy (n = 15); B—subclinical (n = 15); C—heart failure (n = 15); and D—end-stage MMVD (n = 10). Serum malondialdehyde (MDA) and mitochondrial DNA in peripheral blood were analyzed. Quantitative real-time PCR measured mitochondrial DNA, and PCR data were analyzed via the fold-change Ct method. Serum MDA levels were assessed using competitive high-performance liquid chromatography (HPLC). Mitochondrial DNA was significantly lower in group B (−0.89 ± 2.82) than in group A (1.50 ± 2.01), but significantly higher in groups C (2.02 ± 1.44) and D (2.77 ± 1.76) than B. MDA levels were notably elevated in groups B (19.07 ± 11.87 µg/mL), C (23.41 ± 12.87 μg/mL), and D (19.72 ± 16.81 μg/mL) in comparison to group A (9.37 ± 4.67 μg/mL). Nevertheless, this observed difference did not reach statistical significance. It is noteworthy that mitochondrial DNA content experiences a decline during the subclinical stage but undergoes an increase in cases of heart failure. Concurrently, oxidative stress exhibits an upward trend in dogs with MMVD. These findings collectively suggest a potential association between mitochondrial DNA, oxidative stress, and the progression of MMVD in small-breed dogs.
Morphometric Relationships between Length and Weight of 109 Fish Species in the Caribbean Sea (French West Indies)
Authors: Mahé Kélig , Baudrier Jérome , Larivain Angela , Telliez Solène , Elleboode Romain , Bultel Elise , Pawlowski Lionel
Published: December 2023

In total, 109 fish species (24,996 individuals) were sampled around Guadeloupe and Martinique Islands from October 2021 to September 2022 to estimate the morphometric relationships between total length and weight (Length Weight Relationship: LWR) of each fish species according to potential spatial, temporal and sex differences. Of these species, this is the first time that the LWR was estimated in the Atlantic Ocean for 16 species. There is a significant relationship between length and weight for all tested species. For 83 tested species, the sex effect on the LWR showed significant sexual dimorphism for 24 species. Additionally, a link between the temporal effect and the reproduction period was tested for 68 species, of which 35 presented significant differences relative to the annual quarter of sampling. Finally, the geographical effect (i.e., the difference between samples from around Guadeloupe Island and those from Martinique Island) was significant for 60 species. This island effect was significant for 25 species.
An Assessment of the Biological Significance of a Visual Clutch Staging Scheme for Ovigerous Female American Lobster (Homarus americanus)
Authors: Haarr Marthe Larsen , Miller Erin Hope , Gaudette Julien , Rochette Rémy
Published: December 2023

Qualitative visual clutch staging is a useful tool for rapidly and non-invasively assessing the developmental stage of American lobster, Homarus americanus, embryos. While such a scheme has been used in fisheries monitoring strategies in Canada since the 1980s, the biological relevance of its four visually distinguishable stages is poorly understood. We conducted a laboratory experiment in which 10 ovigerous females were housed and the development of their embryos regularly assessed, both qualitatively and quantitatively, from November until hatching in July/August. We confirmed the biological relevance of the qualitative staging scheme by showing clear quantitative differences in the duration and rate of embryonic development of stages 2–4 (stage 1 was not assessed as the precise spawning date was unknown). Stage 2 represents winter–spring “dormancy”. Stage 3 represents a shorter period of rapid development preceding hatch. Stage 4 represents hatching. We also recommend some improvements to the qualitative staging scheme, specifically (1) adding criteria related to the portion of eggs that are occupied by yolk to increase the accuracy of staging, (2) slightly redefining stage 3 to ensure it encompasses the full period of rapid embryonic development pre-hatch, and (3) adding the presence of pre-zoeae as a key indicator of hatching to avoid the misclassification of clutches in the early stages of hatching or those that are completely spent but still have adhesive substance.
Characterization of the Ruminal Microbiome of Water Buffaloes (Bubalus bubalis) Kept in Different Ecosystems in the Eastern Amazon
Authors: Noronha Gerlane Nunes , Hess Melanie K. , Dodds Ken G. , Silva André Guimarães Maciel e , de Souza Shirley Motta , da Silva Jamile Andréa Rodrigues , Graças Diego Assis das , de Carvalho Rodrigues Thomaz Cyro Guimarães , da Silva Welligton Conceição , da Silva Éder Bruno Rebelo , Janssen Peter H. , Henry Hannah M. , Rowe Suzanne J. , de Castro Vinicius Costa Gomes , Lourenço-Júnior José de Brito
Published: December 2023

Increasing the efficiency of rumen fermentation is one of the main ways to maximize the production of ruminants. It is therefore important to understand the ruminal microbiome, as well as environmental influences on that community. However, there are no studies that describe the ruminal microbiota in buffaloes in the Amazon. The objective of this study was to characterize the rumen microbiome of the water buffalo (Bubalus bubalis) in the eastern Amazon in the dry and rainy seasons in three grazing ecosystems: Baixo Amazonas (BA), Continente do Pará (CP), Ilha do Marajó (IM), and in a confinement system: Tomé-Açu (TA). Seventy-one crossbred male buffaloes (Murrah × Mediterranean) were used, aged between 24 and 36 months, with an average weight of 432 kg in the rainy season and 409 kg in the dry season, and fed on native or cultivated pastures. In the confinement system, the feed consisted of sorghum silage, soybean meal, wet sorghum premix, and commercial feed. Samples of the diet from each ecosystem were collected for bromatological analysis. The collections of ruminal content were carried out in slaughterhouses, with the rumen completely emptied and homogenized, the solid and liquid fractions separated, and the ruminal pH measured. DNA was extracted from the rumen samples, then sequenced using Restriction Enzyme Reduced Representation Sequencing. The taxonomic composition was largely similar between ecosystems. All 61 genera in the reference database were recognized, including members of the domains Bacteria and Archaea. The abundance of 23 bacterial genera differed significantly (p < 0.01) between the Tomé-Açu confinement and other ecosystems. Bacillus, Ruminococcus, and Bacteroides had lower abundance in samples from the Tomé-Açu system. Among the Archaea, the genus Methanomicrobium was less abundant in Tomé-Açu, while Methanosarcina was more abundant. There was a difference caused by all evaluated factors, but the diet (available or offered) was what most influenced the ruminal microbiota.
Effects of Dietary Microbial Muramidase on the Growth, Liver Histoarchitecture, Antioxidant Status, and Immunoexpression of Pro-Inflammatory Cytokines in Broiler Chickens
Authors: Omar Anaam E. , El-Rahman Ghada I. Abd , Gouda Ahmed , Abdel-Warith Abdel-Wahab A. , Younis Elsayed M. , Abdo Samar A. , Eltanahy Azhar , Kamal Ahmed Said , Davies Simon J. , Amer Shimaa A.
Published: December 2023

The impact of microbial muramidase (MMUR) addition to broiler chicken rations was evaluated through growth parameters, liver histoarchitecture, antioxidant status, biochemical analysis, and expression of pro-inflammatory cytokines for 35 days. Four hundred three-day-old chicks (97.68 ± 0.59 g) were distributed to four distinct groups with ten duplicates each (100 chicks/group) consisting of: group 1 (G1): a basal diet without MMUR (control group); G2: a basal diet + 200 mg MMUR kg−1 G3: a basal diet + 400 mg MMUR kg−1; and G4: a basal diet + 600 mg MMUR kg−1. The results showed that the final body weight and total weight gain were increased (p = 0.015) in birds fed with diets supplemented with MMUR at 600 mg kg−1. The feed conversion ratio (FCR) was improved in all treatment groups compared with the control group. Birds fed with a diet supplemented with 600 mg MMUR kg−1 showed the highest body weight gain and improved FCR. The values of thyroxin hormones and growth hormones were increased in all MMUR-supplemented groups. Dietary MMUR increased the activities of antioxidant enzymes (total antioxidant activity, catalase, and superoxide dismutase) and decreased the activity of malondialdehyde (p < 0.05). In addition, it increased the values of interleukin 1 beta and interferon-gamma compared with the control group. Furthermore, dietary MMUR increased the expression of transforming growth factor-beta immunostaining in the liver and spleen tissues. Our results show that supplementing broilers’ diets with 600 mg MMUR kg−1 could enhance the chicken growth rate and improve their antioxidant, inflammatory, and anti-inflammatory responses.
The Socioeconomic Impact of Diseases of Working Equids in Low and Middle-Income Countries: A Critical Review
Authors: Bonsi Marta , Anderson Neil E. , Carder Gemma
Published: December 2023

Working equids provide a crucial contribution to the livelihoods and food security of communities in low- and middle-income countries (LMICs). Nevertheless, they are a neglected category within animal health policies and interventions of governmental and non-governmental institutions. This critical review aims to assess the socioeconomic impact of diseases of working equids in LMICs. By highlighting the implications of diseases on working equid welfare, human wellbeing and livelihoods, this review seeks to sensitise policymakers within governments and international organisations to develop policies and interventions aimed at protecting the health of working equids and, consequently, the health and livelihoods of their dependent communities. Twenty relevant publications were identified through the search of five databases (CAB Abstracts, Web of Science Core Collection, BIOSIS, EMBASE and Scopus), backward citation searching and screening of indexes of proceedings and Special Issues retrieved from the database search. The review findings show that diseases of working equids have detrimental socioeconomic effects. However, this subject is under-researched and restricted to few diseases and geographical settings. Considering the complexity of the issue, this review demonstrates that the ‘One Health’ approach represents an opportunity to clarify the link between equid health, human wellbeing and livelihoods, facilitating the translation of research into policy.
Fermented Chinese Herbs Improve the Growth and Immunity of Growing Pigs through Regulating Colon Microbiota and Metabolites
Authors: Zhang Junhao , Shu Zhiheng , Lv Sixiao , Zhou Qingwen , Huang Yuanhao , Peng Yingjie , Zheng Jun , Zhou Yi , Hu Chao , Lan Shile
Published: December 2023

(1) Background: the development of new antibiotic substitutes to promote pig growth and health has become an important way to solve the current dilemma and promote the pig industry. (2) Methods: to assess the effects of a fermented Chinese herbal (FCH) formula on the growth and immunity of growing pigs, 100 Duroc × Landrace × Yorshire three-way crossed growing pigs were randomly divided into control and treatment groups that were fed a basal diet, and a basal diet with 1% (group A), 2% (group B), and 3% (group C) FCH formulas, respectively. A sixty-day formal experiment was conducted, and their growth and serum indices, colonic microbiota, and metabolites were analyzed. (3) Results: the daily gain of growing pigs in groups A, B, and C increased by 7.93%, 17.68%, and 19.61%, respectively, and the feed-to-gain ratios decreased by 8.33%, 15.00%, and 14.58%, respectively. Serum immunity and antioxidant activities were significantly increased in all treatment groups. Particularly, adding a 2% FCH formula significantly changed the colon’s microbial structure; the Proteobacteria significantly increased and Firmicutes significantly decreased, and the metabolite composition in the colon’s contents significantly changed. (4) Conclusions: these results indicate that the FCH formula is a good feed additive for growing pigs, and the recommended addition ratio was 3%.
Finless Porpoise Bycatch and Stranding along the Shandong Peninsula, China, Based on Public Reports from 2000 to 2018
Authors: Zuo Tao , Li Yongtao , Cheng Zhaolong , Wang Jun , Sun Jianqiang , Yuan Wei , Niu Mingxiang
Published: December 2023

The Shandong Peninsula is located on the western coast of the Pacific and is adjacent to the Bohai Sea (BS) and the Yellow Sea (YS) to the east. The East Asian finless porpoise Neophocaena asiaeorientalis sunameri, a subspecies of the narrow-ridged finless porpoise N. asiaeorientalis, is the dominant cetacean resident along the Shandong Peninsula. However, there is insufficient monitoring data to determine the status of the cetacean species in this region. Based on the publicly available literature, media, and internet social website, this study investigated the spatial–temporal distribution of porpoise stranding and bycatch along the coast of the Shandong Peninsula. Data on over five hundred porpoises from two hundred reports between 2000 and 2018 were compiled and analyzed. Results showed that the bycatch and stranding of porpoises occurred widely across the peninsula throughout all months and increased rapidly between 2010 and 2017. The incidents were more frequent in the area where the BS and YS converged during the spring and early summer than in other seasons. The mean body length of bycaught porpoises was smaller than that of those found stranded. Fishing activities could be the principal cause of local finless porpoise incidents. However, limited data hindered a quantitative evaluation of the living conditions of finless porpoises in this area. Establishing a comprehensive monitoring system, which includes standardized reporting, rescue operations, and scientific research, is essential to finless porpoise protection along the Shandong Peninsula.
Which Are the Best Regimens of Broad-Spectrum Beta-Lactam Antibiotics in Burn Patients? A Systematic Review of Evidence from Pharmacology Studies
Authors: Tebano Gianpiero , la Martire Giulia , Raumer Luigi , Cricca Monica , Melandri Davide , Pea Federico , Cristini Francesco
Published: December 2023

Background: Burn injury causes profound pathophysiological changes in the pharmacokinetic/pharmacodynamic (PK/PD) properties of antibiotics. Infections are among the principal complications after burn injuries, and broad-spectrum beta-lactams are the cornerstone of treatment. The aim of this study was to review the evidence for the best regimens of these antibiotics in the burn patient population. Methods: We performed a systematic review of evidence available on MEDLINE (from its inception to 2023) of pharmacology studies that focused on the use of 13 broad-spectrum beta-lactams in burn patients. We extracted and synthetized data on drug regimens and their ability to attain adequate PK/PD targets. Results: We selected 35 studies for analysis. Overall, studies showed that both high doses and the continuous infusion (CI) of broad-spectrum beta-lactams were needed to achieve internationally-recognized PK/PD targets, ideally with therapeutic drug monitoring guidance. The most extensive evidence concerned meropenem, but similar conclusions could be drawn about piperacillin-tazobactam, ceftazidime, cefepime, imipenem-clinastatin and aztreonam. Insufficient data were available about new beta-lactam-beta-lactamase inhibitor combinations, ceftaroline, ceftobiprole and cefiderocol. Conclusions: Both high doses and CI of broad-spectrum beta-lactams are needed when treating burn patients due to the peculiar changes in the PK/PD of antibiotics in this population. Further studies are needed, particularly about newer antibiotics.
Prediction of Cardiorespiratory Fitness Level of Young Healthy Women Using Non-Exercise Variables
Authors: Zadarko Emilian , Przednowek Karolina H. , Barabasz Zbigniew , Zadarko-Domaradzka Maria , Nizioł-Babiarz Edyta , Hulewicz Tomasz , Niewczas-Czarna Klaudia , Huzarski Maciej , Iskra Janusz , Gouveia Élvio Rúbio , Przednowek Krzysztof
Published: December 2023

Cardiorespiratory fitness (CRF) is considered an important indicator of health in children and adults. The main contribution of this paper is an analysis of cardiorespiratory fitness predictive models among a population of healthy and young women, using the non-exercise variables. The study was conducted on a group of 154 healthy women (aged 20.3 ± 1.2) from selected academic centers in Poland. The VO2max was measured using a Cosmed K4b2 portable analyzer during a 20 m shuttle test. In addition, selected anthropomotor parameters including body composition components were measured for each subject. The participants’ leisure-time physical activity was assessed using the Minnesota Leisure-Time Physical Activity Questionnaire. The Ridge regression was the most accurate model for estimating VO2max from anthropometric parameters. The most accurate model based on the level of leisure-time physical activity was calculated using stepwise regression for which the prediction error was at the level of 6.68 (mL·kg−1·min−1). The best model calculated from all non-exercise variables (age, anthropometric parameters, and leisure-time physical activity) had only two predictors: waist circumference and total physical activity, and had a prediction error equal to 6.20 (mL·kg−1·min−1).
Finite Element Analysis of Energy-Absorbing Floors for Reducing Head Injury Risk during Fall Accidents
Authors: Huang Qi , Kleiven Svein
Published: December 2023

Energy-absorbing floor (EAF) has been proposed as one of several biomechanically effective strategies to mitigate the risk of fall-related injuries by decreasing peak loads and enhancing system energy absorption. This study aims to compare the protective capacity of four commercially available EAF products (Igelkott Floor, Kradal, SmartCells, and OmniSports) in terms of head impacts using the finite element (FE) method. The stress–strain curves acquired from mechanical tests were applied to material models in LS-Dyna. The established FE models were then validated using Hybrid III or hemispheric drop tests to compare the acceleration–time curves between experiments and simulations. Finally, the validated FE models were utilized to simulate a typical pedestrian fall accident scenario. It was demonstrated that EAFs can substantially reduce the peak forces, acceleration, and velocity changes during fall-related head impacts. Specifically, in the accident reconstruction scenario, SmartCells provided the largest reduction in peak linear acceleration and skull fracture risk, while Igelkott Floor provided the largest reduction in peak angular velocity and concussion risk. This performance was caused by different energy absorption mechanisms. Consequently, the results can contribute to supporting the implementation of EAFs and determine the effectiveness of various protective strategies for fall-related head injury prevention.
Development and Investigation of Non-Destructive Detection Drive Mechanism for Precision Type Cylindrical Roller Dynamic Unbalance
Authors: Liang Shijie , Duan Mingde , Zhang Zhuangya , Deng Sier , Gao Fenwu
Published: December 2023

In the process of dynamic unbalance detection for precision cylindrical rollers, challenges such as difficulty in achieving effective driving and susceptibility to surface damage during driving significantly impact the accuracy of unbalance detection. This hinders the industry’s ability to achieve the non-destructive detection of cylindrical rollers. Therefore, this paper proposes a novel driving method to enable non-destructive driving of precision cylindrical rollers. The structural principles of the driving mechanism are presented, and a mechanical model for the cylindrical roller is established to analyze the force distribution. Subsequently, a mathematical model for the air film bearing the cylindrical roller is developed to study the variation characteristics of the air film’s load-bearing capacity. The optimal air film thickness is determined, and the rationality of the mathematical model is validated through simulation analysis. Finally, an experimental platform for non-destructive driving is constructed to further verify the effectiveness of the proposed method. This research provides a prerequisite for the non-destructive detection of dynamic unbalance in precision cylindrical rollers.
Robust Speed Control of a Multi-Mass System: Analytical Tuning and Sensitivity Analysis
Authors: Alhanouti Muhammed , Gauterin Frank
Published: December 2023

The regeneration of highly dynamic driving maneuvers on vehicle test benches is challenging due to several influences, such as power losses, vibrations in the overall system that involves the vehicle with the test bench, uncertainties in the model parameterization, and time delays from both the test bench and the measurement systems. In order to improve the dynamic response of the vehicle test bench and to overcome system disturbances, we employed different types of control algorithms for a mechanical multi-mass model. First, those controllers are extensively investigated in the frequency domain to analyze their stability and evaluate the noise rejection quality. Then, the expectations from the frequency analysis are confirmed in a time-domain simulation. Furthermore, sensitivity analysis tests were conducted to evaluate each controller’s robustness against the modeling parameters’ uncertainty. The linear quadratic controller with integral action demonstrated the best compromise between performance and robustness.
The Influence of Low-Pressure Plasma Treatments on the Lap Shear Strength of Laser-Joined AISI 304 Hybrids with Polypropylene and Polyamide 6.6
Authors: Tillmann Wolfgang , Wojarski Lukas , Hopmann Christian , Fatherazi Patricia , Timmer Christian
Published: December 2023

This paper investigates if the polar groups induced by a plasma treatment can increase the lap shear strength of laser-joined metal and plastic hybrids. Optimal laser joining parameters for cold-rolled AISI304–polyamide 6.6 and sandblasted AISI304–polypropylene hybrids were developed at 2.85 MPa and 4.22 MPa, respectively. The surface free energy was doubled for all used plasma gases to a value of ca. 80 mN m−1 at 180 s. The plasma-treated samples were joined and tested. The arithmetic means of the plasma-treated hybrids’ lap shear strength with polyamide 6.6 varied slightly, but all measured values were within the range of the untreated samples. Residue on the sheared metal samples indicated covalent bonds between AISI304 and polyamide 6.6. The lap shear strengths of the plasma-treated polypropylene hybrids were significantly reduced between −30.8% and −53.3%, depending on the used plasma gas. This was attributed to the over-aging and development of low-molecular-weight oxidized materials, which led to a weak boundary layer. No residue of polypropylene was found on treated or untreated lap shear samples. No correlation between the surface free energy and lap shear strength could be found.
Machine-Learning-Based-Approaches for Sleep Stage Classification Utilising a Combination of Physiological Signals: A Systematic Review
Authors: Almutairi Haifa , Hassan Ghulam Mubashar , Datta Amitava
Published: December 2023

Increasingly prevalent sleep disorders worldwide significantly affect the well-being of individuals. Sleep disorder can be detected by dividing sleep into different stages. Hence, the accurate classification of sleep stages is crucial for detecting sleep disorders. The use of machine learning techniques on physiological signals has shown promising results in the automatic classification of sleep stages. The integration of information from multichannel physiological signals has shown to further enhance the accuracy of such classification. Existing literature reviews focus on studies utilising a single channel of EEG signals for sleep stage classification. However, other review studies focus on models developed for sleep stage classification, utilising either a single channel of physiological signals or a combination of various physiological signals. This review focuses on the classification of sleep stages through the integration of combined multichannel physiological signals and machine learning methods. We conducted a comprehensive review spanning from the year 2000 to 2023, aiming to provide a thorough and up-to-date resource for researchers in the field. We analysed approximately 38 papers investigating sleep stage classification employing various machine learning techniques integrated with combined signals. In this study, we describe the models proposed in the existing literature for sleep stage classification, discuss their limitations, and identify potential areas for future research.
On the Vaneless Space Vortex Structures in a Kaplan Turbine Model Operating at Speed No Load
Authors: Roig Rafel , Sánchez-Botello Xavier , Mulu Berhanu , Högström Carl-Maikel , Escaler Xavier
Published: December 2023

The growing installation of intermittent renewable energy sources is forcing hydraulic turbines to work more frequently at speed no load when dangerous vaneless space vortex structures and stochastic flow phenomena can occur. An experimental campaign has been performed in a reduced-scale Kaplan turbine model at speed no load for different combinations of guide vane and runner blade angles under non-cavitation and cavitation conditions. Several simultaneous vaneless space vortex structures, all of them inducing torsional rotor vibrations, have been observed. Nonetheless, only one of them has been found to dominate over the rest depending on the blade and guide vane angles. Off-board pressures, torques and vibrations as well as on-board strains have been measured to characterize their nature, intensity, dynamic behavior and induced structural response. Their precession frequencies have been found to depend on the discharge factor, the number of vortices and their location inside the vaneless space. Under cavitation conditions, their dynamic behavior has not been significantly altered but the induced structural response has increased at the low-pressure side of the turbine.
Resistance Training Using Flywheel Device Improves the Shot Precision in Senior Elite Tennis Players: A Randomized Controlled Study
Authors: Centorbi Marco , Fiorilli Giovanni , Di Martino Giulia , Buonsenso Andrea , Medri Gabriele , della Valle Carlo , Vendemiati Nicolina , Iuliano Enzo , Calcagno Giuseppe , di Cagno Alessandra
Published: December 2023

The aim of the study was to assess the effects of 8 weeks of resistance training using a flywheel device applied to upper limbs, compared to traditional isotonic training, on strength and shot precision in tennis. Twenty-seven elite senior tennis players (age: 55.78 ± 2.69) were randomly divided into an experimental group (EG) using flywheel devices (n = 13) and a control group (CG) performing isotonic training (n = 14). The EG program included forehand, backhand, and one-handed shoulder press movements, while the CG performed seven resistance exercises on isotonic machines. A similar workout intensity was ensured using the Borg’s CR-10 scale. The assessment included a 30s arm curl test, a medicine ball throw test, and forehand/backhand/overhead shot precision tests. A significant time effect was found in the 30s arm curl test for the EG (F(1,25) = 13.09; p = 0.001), along with a time * group interaction (F(1,25) = 5.21; p = 0.031). A significant group difference was observed in the forehand shot precision test, where the EG achieved better scores than the CG and significant interaction time * group (F(1,25) = 8.35; p = 0.008). In the shot backhand precision test, a significant effect of time (F(1,25) = 5.01; p = 0.034) and significant time * group interaction were found (F(1,25) = 4.50; p = 0.044), but there was no significant difference between groups. Resistance training with flywheel devices has shown potential in improving tennis performance. Applying overload to specific athletic movements during both concentric and eccentric phases in the EG has shown enhanced strength and neuromuscular coordination in relation to shot precision, thereby enabling simultaneous improvements in both conditioning and the technical aspects of fundamental tennis shots.
Dynamic Spectrum Assignment in Passive Optical Networks Based on Optical Integrated Microring Resonators Using Machine Learning and a Routing, Modulation Level, and Spectrum Assignment Method
Authors: Calvo-Salcedo Andrés F. , González Neil Guerrero , Jaramillo-Villegas Jose A.
Published: December 2023

The rising demand for bandwidth in optical communication networks has led to the need for more efficient solutions for spectrum allocation. This article presents a solution to enhance the capacity and efficiency of passive optical networks (PON) using optical microring resonators and dynamic spectrum allocation. The solution relies on wavelength division multiplexing (WDM). It proposes using a support vector machine (SVM) and a Routing, Modulation Level, and Spectrum Assignment (RMLSA) method to manage spectrum allocation based on the bandwidth and distance of multiple requests. The network employs a pulse shaper to physically allocate the spectrum, allowing for the separation of the spectrum generated by the microring resonators into different wavelengths or wavelength ranges (super-channel). Additionally, the SVM and RMLSA algorithms regulate the pulse shaper to execute the allocation. This photonic network achieves improved spectrum utilization and reduces the network blocking probability. Our proposal shows that we successfully addressed 1090 requests with a zero blocking probability, accounting for 81% of the total requests. These request scenarios can simultaneously accommodate up to 200 requests, with a maximum bandwidth of 31 THz. This highlights the efficacy of our approach in efficiently managing requests with substantial processing capacity.
Study of Gravelly Soil Core Material Using a Large-Scale Triaxial Wetting Test
Authors: Qin Yuyang , Li Guoying , Mi Zhankuan , Fan Kaifang
Published: December 2023

Wetting deformation has a significant impact on dam safety, and is one of the leading causes of the long-term deformation of dams. For dams to operate safely, it is crucial to precisely estimate the extent of wetting deformation using a reasonable calculation model. This study describes the wetting deformation behavior of gravelly soil core material observed at a hydropower station using a large-scale triaxial wetting test, and the process, characteristics, and mechanism of the wetting deformation are analyzed. The results show that the direction of the wetting deformation exhibits different behaviors influenced by the stress levels. Compared with the significant changes in the wetting direction observed under low stress levels, the changes in the wetting direction under high stress levels appears to lag behind those in wetting deformation. The source of wetting deformation is thought to be the weakening of a material when it encounters water. Thus, a new calculation model of the wetting deformation of gravelly soil core material is proposed. In this model, the wetting strain ratio is in an exponential relationship with the stress levels, and the new model is used to simulate the triaxial wetting test on the gravelly soil core material; its validity and practicability are further evaluated, providing a new computational approach for analyzing the wetting deformation behavior of dams.