bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformation de la Pologne : faits et mythes sur la période 1990-2020 et les chances du pays d'atteindre le niveau économique des États-Unis et de l'Allemagne après 2020
Authors: Gomulka Stanislaw
Published: August 2022

Cet article étudie les évolutions économiques révolutionnaires en Pologne après le début de la transformation systémique en 1989. Trois groupes de pays sont utilisés pour l ' analyse comparative : les plus avancés économiquement, les moins développés mais s ' efforçant de rattraper leur retard au cours des derniers 30-40 ans, et en tant que sous-groupe de ces derniers, les économies en transition. Le document a trois objectifs. Le premier consiste à montrer que de nombreuses opinions concernant les principaux aspects de la transformation polonaise sont en contradiction avec les faits statistiques simples. Le deuxième consiste à évaluer le rythme et l ' ampleur des progrès réalisés jusqu ' ici dans l ' effort visant à réduire les écarts de revenus et de richesse entre la Pologne et la plupart des pays développés, en particulier les membres de l ' Union européenne d ' avant 2004. Le troisième consiste en une discussion des facteurs susceptibles d ' entraver le rythme du développement économique de la Pologne dans les années à venir.
L'Évolution des écarts régionaux d'offere universitaire en France entre 1980 et 2000 : Spécialisation ou differsification?
Authors: Jaoul-Grammare Magali , Pellier Karine
Published: August 2022

L ' objet de cet article est de s ' interroger sur la répartition de l ' offre de formation universitaire en France. Y-a-t-il eu une spécialisation régionale universitaire ou au contraire a-t-on observé une diversification des régions ? Après avoir étudié l ' évolution des écarts régionaux pour chaque discipline universitaire entre 1980 et 2000 nous tentons d ' identifier les spécificités de chaque région dans l ' offre de formation. Les résultats obtenus montrent qu ' il existe une certaine atténuation des écarts régionaux, essentiellement pour les disciplines rentables économiquement. En revanche si l ' on n ' identifie pas réellement de spécialisations régionales, nous mettons en évidence un type de spécialisation que l ' on pourrait qualifier de « spécialisation historique ».
Pouvoir de marché et tarifications du crédit : cas de l'UEMOA
Authors: Ndiaye Abdoulaye
Published: August 2022

Cet article évalue la relation entre le pouvoir de marché et la tarification du crédit sur un échantillon de 49 banques de 7 pays de l ' Union Économique et Monétaire Ouest Africaine (UEMOA) sur la période de 2003 à 2014. Notre méthodologie empirique relie une analyse des données de panel et une régression non linéaire. Nos résultats montrent que le pouvoir de marché influence positivement la tarification du crédit dans l ' UEMOA. Cela conforte l ' hypothèse du pouvoir de marché qui stipule que la concentration du marché incite à une forte tarification des produits bancaires (taux débiteurs plus élevés et taux créditeurs plus bas, donc marges d ' intérêt importantes) et limite l ' accès au financement. La régression non linéaire met en évidence l ' existence d ' un seuil qui n ' est pas significatif dans notre échantillon car, seul le premier ou le deuxième centile des données de notre échantillon vérifie le second régime. Alors que les 98% ou 99% restant confirment les résultats du modèle linéaire. Ces résultats ont d ' importantes implications de politiques de régulation bancaire dans l ' UEMOA.
Existe-t-il un lien entre le regime de change et la diversification des exportations dans les pays de la CEDEAO?
Authors: Amadou Akilou , Baoula Kodjo W. , Ali Yézidou
Published: August 2022

Le choix des régimes de change demeure un sujet important mais controversé dans les pays en voie de développement qui restent ouvert au reste du monde et dont les exportations sont tributaires des produits primaires. L ' objectif de ce papier est d ' analyser l ' effet du régime de change sur la diversification des exportations des pays de la CEDEAO. Pour ce faire, nous avons adopté une investigation empirique basée sur une régression d ' un modèle linéaire en données de panel constitué de 10 pays de la CEDEAO, sur la période 1990 à 2014, avec la technique d ' estimation des IV-2SLS. Nos résultats indiquent principalement que le régime de change fixe est significativement favorable à la diversification des exportations dans les pays de la CEDEAO. Au regard de ces résultats, pour améliorer la diversification des exportations, les gouvernements de ces pays doivent entreprendre des politiques destinées à maintenir la stabilité de leurs monnaies nationales vis-à-vis des monnaies étrangères à travers une politique de change appropriée.
Effect of Organic Selenium during HS in Broiler Chicken: The Interplay of HSP-70 and PGC-1α
Authors: Jayasri K. , Padmaja K. , Prasad P. Eswara , Ravi A. , Adilaxmamma K. , Kumari B. Punya , Chaitanya R.K.
Published: August 2022

Background: ROS ( Reactive Oxygen Species) accumulated during heat stress induced oxidative stress is involved in triggering the activation of transcription factor, heat shock factor-1 (HSF-1) which further results in the up regulation of HSP. A cooperation between PGC1α and HSF1 in the induction of HSPs in response to thermal stress was reported in mice. Thus, the present study was conducted to investigate the effect of HS (Heat Stress) on HSP-70 and PGC-1α expression in broilers. Method: The study was conducted in two phases, one during autumn and the other during summer with a total of 300 birds. During the first phase, 60 chicks were divided into six replicates with 10 birds in each and during the second phase, 240 chicks were divided into four groups with six replicates containing 10 birds in each. The experimental rations given to different groups were as control (Basal ration), HS I (Basal ration), HS II (Basal ration+0.3 ppm Se, HS III (Basal ration+0.6 ppm Se) and HS IV (Basal ration+0.9 ppm Se). Hepatic tissues were collected for analysis at 21 d and 42 d. Result: The MDA levels and expression of HSP-70 protein in hepatic tissues were increased due to HS both at 21 and 42 d, while the expression of PGC-1α protein increased at 42 d. Se supplementation at 0.3 ppm was effective in decreasing the concentration of MDA and HSP-70 protein at 21d, whereas 0.6 ppm and 0.9 ppm were effective at 42d. Se supplementation decreased the expression of PGC-1α protein at 42 d during HS.
Pengembangan Digital B-OK Bentuk Muka Bumi Malang Raya sebagai Sumber Belajar IPS SMP Kelas VII
Authors: Nadhianty Ardhina , Purnomo Agus
Published: August 2022

Social Studies is one of the subjects that has a variety of learning material, one of which is the natural environment. The natural environment as a learning material has several limitations so that media is needed that functions as a container in the process of conveying messages to students. The media that can be used to address these problems is digital books. This study aims to describe the prototype development design of Digital BOK with the material of the Earth Form of Malang Raya. The results of research and development are in the form of a digital book that contains material on the shape of the Earth of Malang Raya in PDF format accompanied by a QR Code that can be accessed by users to view videos of the topography of Malang Raya which is expected to be able to provide alternative learning material and supplement books, as well as a form of implementing environmental digitization. around students. Product development in this study uses an RD (Research and Development) approach with ADDIE design. The results of product validation show the percentage score of 85% for validation of learning content, 80% for language validation, and 97.5% for learning media validation. Meanwhile, the results of trials on prospective users or validation by social studies teachers at SMP obtained an average percentage of 84.7%. Based on these percentages, it can be concluded that the Digital B-OK Bentuk Muka Bumi Malang Raya can be categorized as "very feasible" for further use in learning activities.
Podcast Kearifan Lokal sebagai Media Penguatan Karakter Mahasiswa
Authors: Ramli Nur Leli
Published: August 2022

Education providers are one of the sectors forced to change the pattern of offline to online learning due to the COVID-19 pandemic. Students, as members of the native generation, are certainly already familiar with information technology systems that are widely open. When experiencing difficulties, they will use the available platforms to find solutions without communicating directly with the people around them. As a result, they think practically and unconcerned about their environment. Podcasts are an alternative platform for distance learning because they involve professionalism in sharing content or inviting students to collaborate as resource persons. Other students can interact through written communication during learning, allowing feedback to be felt and an emotional connection to be formed. The content of local wisdom values is inserted at every meeting with the goal of instilling and developing student character behaviors. The study included 30 participants, and descriptive statistical analysis revealed that 85% of students were satisfied with using local wisdom podcasts as a learning medium.
Development of a Field Laboratory to Social Science Education Pre-Service Teacher
Authors: Bashith Abdul , Amin Saiful , Mkumbachi Ramadhani Lausi
Published: August 2022

This study aims 1) to describe the physical, social, economic, and cultural potential of the Social Science Education field laboratory object on the slopes of Mount Tengger and 2) to produce a product in the form of a manual for the Social Science Education field laboratory. The Dick and Carey model was used in this development with simplified stages. Qualitative data are in the form of 1) a description of the object of research and (2) suggestions for product improvement from the validator of learning and design experts. Quantitative data are in the form of response scores from expert validators and students during limited trials. The instruments in this study were observation sheets, interview guidelines, documentation, and questionnaires. The data analysis used in this study is a descriptive analysis to examine the relevance of various subjects in the Social Science Education Department with the objects that are scattered in the study area. Furthermore, descriptive statistical analysis is used to process the questionnaire data with a Likert scale of 1 (very poor) to 4 (very good). The results showed that first, the physical, social, economic, and cultural potential in the research object supported the feasibility of developing a social science education field laboratory. Second, the manual for the Social Science Education field laboratory is suitable for use in outdoor social studies learning with a feasibility value of 87.25 (very feasible).
Redefining Health-Care Simulation Facilitator Professional Development through Online Learning
Authors: Poore Julie , Herrington Alaina , Hardie Lori
Published: August 2022

Competition for nursing clinical sites has intensified as universities have increased enrollment to meet the growing demand for nurses. Hospital mandates have reduced opportunities for nursing students to practice clinical skills, leading nursing programs to use simulation to help learners gain the knowledge, skills, and attitudes needed for transition to clinical practice. Simulation offers a safe learning environment and a guarantee that every student will have experience with critical clinical encounters. To be effective, health-care simulation must be facilitated by trained educators knowledgeable in simulation pedagogy, including theory-based simulation frameworks and debriefing models. Training simulation facilitators is often challenged by financial and time constraints. The need for an easily accessible, asynchronous, cost-effective method of providing foundational simulation training led a group of experienced simulationists to develop a series of seven online educational modules grounded in simulation best practices.
Critical Race Theory: A Framework for the Re-Education of American Nurses
Authors: Iheduru-Anderson Kechinyere C. , Alexander G. Rumay
Published: August 2022

The nursing profession has been predominantly white and female since the time of Florence Nightingale. The United States 2020 census revealed a changing demographic landscape in which white people are no longer the majority race; this shift will continue well into the future based on who is having babies. Calls to diversify the nursing workforce and address disparities and inequities in health care continue. Nursing faculty who shape curricula are challenged to create a more inclusive framework to teach students about care. Without focused attention on how to prepare future nurses to care for all people, patient safety and quality of care are at stake. This article suggests using critical race theory as a framework to re-educate American nurses.
Digital Poverty in the UK
Authors: Faith Becky , Hernandez Kevin , Beecher James
Published: August 2022

As every aspect of life – from job seeking to health care – moves online, digital connectivity is a daily necessity, not a luxury. Against the backdrop of the UK’s worst cost of living crisis in 40 years, discussions about fuel and food poverty are now joined by a new concern with what has become known as digital poverty – challenges affording the cost of online connectivity and devices. Using data from a survey of low-income households, this Policy Briefing explores the extent of digital poverty in the UK and shows how it can exacerbate other forms of poverty among the most disadvantaged households. It also shows how current fixes, including social tariffs aimed at the poorest in society, are not effectively addressing this critical issue.
Problem winy umyślnej przy przestępstwie znęcania się nad zwierzętami
Authors: Helios Joanna , Jedlecki Mikołaj
Published: August 2022

Niniejszy artykuł stanowi próbę refleksji nad rolą winy jako konstrukcji karno-prawnej dla prawnej ochrony zwierząt przy przestępstwie znęcania się nad zwierzętami. Wyodrębniono w nim dwie grupy problemów: po pierwsze, pojęcie winy w prawie karnym, ze szczególnym uwzględnieniem winy umyślnej i zamiaru bezpośredniego; po drugie, analizę przestępstwa znęcania się nad zwierzętami w doktrynie i orzecznictwie sądowym.
The Level of IgA Antibodies to CD74 in Patients with Spondyloarthritis and Degenerative-Dystrophic Diseases of the Spine
Authors: Rebrov A. P. , Gaydukova I. Z. , Aparkina A. V. , Korolev M. A. , Safarova K. N. , Dorogoikina K. D. , Bichurina D. M.
Published: August 2022

Background. According to the scientific literature, anti-CD74 IgA antibodies (IgA anti-CD74) are considered as a possible marker for the diagnosis of axial spondyloarthritis (SpA). The level of IgA anti-CD74 in patients with back pain due to degenerative spine disease has not been studied. Therefore, it could be interesting to compare the serum levels of IgA anti-CD74 in patients with chronic back pain in various diseases. Aim: to compare the levels of IgA anti-CD74 in patients with SpA and degenerative spine diseases. Material and methods. A total of 87 SpA patients (55 male, mean age 41 [29; 49] years) fulfilling the Assessment of Spondyloarthritis International Society (2009) criteria for Axial SpA, and 39 patients (25 male, mean age 45 [34; 53] years) with neurologist-verified degenerative spine diseases (ICD 10 codes — M 51.1 and M 54.4) were enrolled to the study. The serum levels of IgA anti-CD74 were analyzed by enzyme-linked immunosorbent assay (ELISA) in all patients. Results. The median levels of IgA anti-CD74 in patients with SpA were 11.3 [5.4; 19.4] U/ml, in patients with degenerative spine disease — 6.9 [4.5; 13.7] U/ml (p=0.024). IgA anti-CD74 serum levels were above the cut-off value in 58 (66.7 %) patients with SpA and only in 11 (28.2 %) patients with degenerative spine disease (p<0,001). The elevated serum levels of IgA anti-CD74 were detected in 10 (40 %) of 25 male patients and in 1 (7.1 %) of 14 female patients (p = 0.029, χ2 = 4.785) with degenerative spine disease. Conclusion. Serum levels of I gA anti-CD74 were increased in two-thirds of patients with SpA. IgA anti-CD74 was significantly higher in SpA patients compared to patients with degenerative spine disease. >< 0,001). The elevated serum levels of IgA anti-CD74 were detected in 10 (40 %) of 25 male patients and in 1 (7.1 %) of 14 female patients (p = 0.029, χ2 = 4.785) with degenerative spine disease. Conclusion. Serum levels of I gA anti-CD74 were increased in two-thirds of patients with SpA. IgA anti-CD74 was significantly higher in SpA patients compared to patients with degenerative spine disease.
The Influence of Accounting and Auditing Regulations on Decisions Regarding External Growth Strategies in Romanian Industry
Authors:   Alexandru Ioan Cuza” University of Iasi, Romania, AEVOAE George Marian
Published: August 2022

Purpose – The purpose of this paper is to identify the chances that a certain type of investor will purchase a stake in an industry target company, considering the accounting practices and / or the audit opinion, to which certain financial information is added, related to size and profitability. The influence of these factors on the acquisition decision, reflected in the deal value, is also analyzed. Methodology – For testing and validation of working hypotheses, multinomial logistic regression, generalized linear models and multiple correspondences analysis are used, considering a sample of 631 acquisitions from the Bucharest Stock Exchange (BSE). Results – The undisclosed investors (in most cases, individuals) are interested in the size of the company, while companies consider the quality of the information provided by the target company, which applies IFRS and has the financial statements accompanied by the opinion of an auditor. Profitability is a significant factor for unlisted investors. As for the price that these investors decide to pay in the transaction, it is positively influenced by all the factors mentioned above. Originality – The study provides an overview of the types of investors who acquire stakes on the BSE and of the factors that influence the chances that they will pay a certain price for equity stakes.
“Portrait of Prof. Gilewski” by Jan Matejko. Relations of outstanding individuals in art and science of the 19th century
Authors: Kierzek Andrzej , Kotuła Jacek
Published: August 2022

W historii polskiego rynku aukcyjnego najdroższym obrazem sprzedanym na aukcji jest „Portret Profesora Karola Gilewskiego” Jana Matejki (1838-1893). Artykuł pokrótce przedstawia dokonania Karola Gilewskiego (1832-1871), profesora Uniwersytetu Jagiellońskiego, lekarza wszechstronnie wykształconego, który jak większość ówczesnych chirurgów i internistów zajmował się także chorobami uszu, nosa, gardła i krtani. Jego pionierska praca na temat rozszczepienia krtani w leczeniu polipów krtani zajmuje w historii polskiej medycyny miejsce wyjątkowe. Ponadto zanalizowano stan zdrowia Jana Matejki, wybitnego polskiego malarza, i zaakcentowano rolę Karola Gilewskiego w procesie leczenia tego artysty.
Analysis of the Potential Attraction of Eco-Karst Tourism of Maron River, Dersono Village, Pringkuku District Pacitan Regency
Authors: Wijayanti Pipit , Zamani Muhammad Zaki
Published: August 2022

Tourism is one of the ways for residents at the village to gain income and aslo a contributor to the national economy. The tourism that is found in every village nowadays favors the potential of the surrounding nature. Pacitan Regency is known to have tourism potential related to the advantages of its karst landscape. Pacitan also got the nickname "1000 Goa" because there are many karst caves found there. Villages in Pacitan Regency have developed a lot of eco-karst tourism. Dersono Village is a village located in Pringkuku District, Pacitan Regency. There is one leading eco-karst tourism in the village that is currently being managed, namely the Maron River. Although it has similarities with other tourism in Pacitan Regency, which is the same theme of eco-karst, however Maron River certainly has its own attraction which made tourists who come to Pacitan Regency decided to visit the Maron River This study aims to analyze the potential for tourism attraction of Maron River based on the 4A tourism components. The method used in this study is descriptive research with data collection through observation and interviews. Based on the results of the study, the study found that the tourism attraction of Maron River based on 4A has met the parameters. However, it still needs to be developed so that the number of tourist visits continues to increase and can be expanded with new eco-karst attractions.

 
LA NORMA SUSTANCIAL CODIFICADA EN LA EDUCACIÓN DE LOS ABOGADOS DEL SIGLO XXI Y EL IMPERATIVO DE LOS ODS
Authors:   Universidad de Medellín, Ramírez Carvajal Diana , Guerra Moreno Débora , Franco Ramírez Vanessa ,   Universidad Libre,   Universidad Católica de Oriente
Published: August 2022

The correct application of the law depends to a large extent on a good legal education, which must be reformulated around the new dimensions of global justice and the ODS, unmasking the emotional and ideological veils, inherited from the codifications of the 19th century. This article highlights the importance of untying the history of legal education, strengthening the study of the process and the evidence for the judicial justice of the 21st century, which must revolve around the 2030 Agenda. Strengthening procedural guarantees, deepening argumentation, epistemology, logic and philosophy, will lead the lawyer of the future to work for a healthy coexistence and a more just world.
EL DERECHO NATURAL EN LA CONSTITUCIÓN POLÍTICA DE COLOMBIA, UNA VISIÓN DESDE LOS POSTULADOS DE JAVIER HERVADA
Authors:   Universidad del Atlántico, Restrepo Pimienta Jorge Luis , Cruz Mahecha Diego Enrique , Fonseca Deluque Roberto de Jesús ,   Universidad Libre.
Published: August 2022

The thematic plurality and the prolixity of the texts and acknowledgments that are integrated into the Political Constitution of Colombia of 1991 allow it to be studied and considered from different perspectives and criteria, both doctrinal and argumentative. On this occasion, we will proceed to demarcate those features of the constitutional text that allow us to highlight its correlation with the postulates that, regarding the theory of natural law, Javier Hervada has established. To achieve this objective, the criteria of a dialogical methodology will be used, through which it is possible to establish a kind of conversation between the constitutional texts and the postulates that Hervada expresses, which are typical of the so-called natural law. The method used in this research does not deviate from the methodology that will be used, since it corresponds to the dialogical criteria between texts, which will allow the construction of conceptual reasoning that denotes the conceptual identity between the Constitutional Charter and the principles of law. natural, expressed in the work of Hervada. With this paper we intend to address a conceptual problem that demands that the relationship of the criteria of a conceptual aspect of Law, such as Natural Law, be clarified from a theoretical perspective, with an apparently neutral text, in terms of what that it refers to its ideological source, such as the Political Constitution of Colombia, which in its practical development, and more in the evolution, which the judiciary has given it, has been valued from the criteria of legal positivism, of legal realism, and even from the orbit of ius-naturalism.
Engineering With Nature® principles in action : islands
Authors: Whitfield Paula , Suedel Burton , Egan Kelly , Corbino Jeffrey , Davis Jenny , Carson David , Tritinger Amanda , Szimanski Danielle , Balthis William , Gailani Joseph , King Jeffrey
Published: August 2022

The Engineering With Nature® (EWN) Program supports nature-based solutions that reduce coastal-storm and flood risks while providing environmental and socioeconomic benefits. Combining the beneficial use of dredged sediments with the restoration or creation of islands increases habitat and recreation, keeps sediment in the system, and reduces coastal-storm and flood impacts. Given the potential advantages of islands, EWN seeks to support science-based investigations of island performance, impacts, and benefits through collaborative multidisciplinary efforts. Using a series of case studies led by US Army Corps of Engineers (USACE) districts and others, this technical report highlights the role of islands in providing coastal resilience benefits in terms of reducing waves and erosion as well as other environmental and socioeconomic benefits to the communities and the ecosystems they reside in.
South Pole Station snowdrift model
Authors: Allen Luke , Haehnel Robert , Wenren Yonghu
Published: August 2022

The elevated building at Scott-Amundsen South Pole Station was designed to mitigate the effects of windblown snow on it and the surrounding infrastructure. Because the elevation of the snow surface increases annually, the station is periodically lifted on its support columns to maintain its design height above the snow surface. To assist with planning these lifts, this effort developed a computational model to simulate snowdrift formation around the elevated building. The model uses computational fluid dynamics methods and synthetic wind record generation derived from statistical analysis of meteorological data. Simulations assessed the impact of several options for the lifting operation on drifts surrounding the elevated building. Simulation results indicate that raising the eastern-most building section (Pod A), or the entire station all at once, can reduce drift accumulation rates over the nearby arches structures. Long-term analyses, spanning 5–6 years, determine whether an equilibrium drift condition may be reached after a long period of undisturbed drift development. These simulations showed that after about 6 years, the rate of growth of the upwind drift slows, appearing to approach an equilibrium condition. However, the adjacent drifts were still increasing in depth at a roughly linear rate, indicating that equilibrium for those drifts was still several seasons away.
Simultaneous transformation of ginsenoside Rb1 into rare ginsenoside F2 and Compound K by the extracellular enzyme from Aspergillus Niger Wu-16
Authors: Yang Fan , Wu Zhansheng , Cao Shanshan , Tao Zhidong , Fan Daidi , Liu Xiaochen
Published: August 2022

Ginsenoside Compound K (CK) has high pharmacological activity for being widely used in the treatment and prevention of diseases. However, the content of CK in ginseng is very low or almost non-existent. In the present study, ginsenoside Rb1 was converted into ginsenoside F2 and CK by using the extracellular protein isolated from Aspergillus niger Wu-16. The results show that the crude enzymes produced by Wu-16 can catalyze the conversion of the substrate Rb1 to ginsenoside F2 and CK. The reaction time, pH, temperature, and ratio of enzyme to substrate for preparing ginsenoside F2 and CK were used as optimization factors. A reaction time of 48 h, pH=3, temperature of 55°C, and enzyme-to-substrate ratio of 0.8 were obtained. Furthermore, response surface optimization experiment was carried out to further obtain the maximum conversion rates of ginsenoside F2 and CK with 50.11% and 33.50% for 48 h, respectively. On this basis, the effect of metal ions on the enzymatic reaction showed that the conversion rate of ginsenoside Rb1 was increased remarkably by Co2+ with concentrations of 0.5 mM, and the highest conversion rate into rare ginsenoside CK reached 56.10%. Therefore, the advantage of enzymes catalysis from A. Niger Wu-16 could be a simple, convenient, and rapid method to produce rare saponin F2 and CK, this method provides a certain reference value for the production of rare ginsenosides.
Design and Analysis of 4x2 Optical Encoder using Waveguides and Defects Mechanism in Two Dimensional Photonic Crystals
Authors: Gogga Sanjeev , Gowre Sanjaykumar C , Sonth Mahesh V , Miyan Hameed
Published: August 2022

The proposed encoder in two dimensional photonic crystals is analyzed interms of flow of light inside waveguides. Waveguides have been created by removing silicon rods in the structure and defects with smaller radii have been created to achieve the proper couplers operations. The photonic band gap of the proposed encoder is determined and their performance is evaluated using finite difference time domain method. The proposed design has an optical output power threshold range between 76-94% for ON state and threshold level of OFF state is below 20%. The proposed encoder is operated in the wavelength of 1550 nm. Hence, it is applicable for high speed optical integrated circuit. The response time and contrast ratio calculated from the proposed encoder are 0.24 ps and 8.59 dB which are comparatively better than the literature reported with compare to footprint area of the proposed encoder.
Mycorrhizal fungi reduce the photosystem damage caused by drought stress on Paris polyphylla var. yunnanensis
Authors: Huang Can , He Xiahong , Shi Rui , Zi Shuhui , Xi Congfang , Li Xiaoxian , Liu Tao
Published: August 2022

Drought stress (DS) is one of the important abiotic stresses facing cash crops today. Drought can reduce plant growth and development, inhibit photosynthesis, and thus reduce plant yield. In this experiment, we investigated the protective mechanism of AMF on plant photosynthetic system by inoculating Paris polyphylla var. yunnanensis with a clumping mycorrhizal fungus (AMF) under drought conditions. The drought environment was maintained by weighing AM plants and non-AM plants. The relative water content (RWC) of plant leaves was measured to determine its drought effect. DS decreased the RWC of plants, but AMF was able to increase the RWC of plants. chlorophyll a fluorescence curve measurements revealed that DS increased the OKJIP curve of plants, but AMF was able to reduce this trend, indicating that AMF increased the light absorption capacity of plants. dS also caused a decrease in plant Y(I) and Y(II). ETRI and ETRII, and increased Y(NO) and Y(NA) in plants, indicating that DS caused photosystem damage in plants. For the same host, different AMFs did not help to the same extent , but all AMFs were able to help plants reduce this damage and contribute to the increase of plant photosynthesis under normal water conditions.This work was supported by the Key R & D program of Yunnan Province, China (grant no. 202103AC100003；202101AS070228)；Major special projects of the Ministry of science and technology (2021YFD1000202)；the National Nature Science Foundation of China (Grant No. 31860075)
Bcl-2 associated transcription factor 1 promotes proliferation but inhibits self-renewal of embryonic spinal cord neural stem/progenitor cells through enhancing the mammalian target of rapamycin complex 1 signaling
Authors: He Xu , Li Pian , Kang Zhengwen , Tian He , Miao Ping , Zhang Qiusheng , Lin Wenping
Published: August 2022

Background
Spinal cord neural stem/progenitor cells (NSPCs) have great potential to reconstitute damaged spinal neural circuitry. However, the mechanisms regulating their activities have not been thoroughly understood. In this study, we revealed the expression and function of Bcl-2-associated transcription factor 1 (BCLAF1) in mouse NSPCs.
Methods
Mouse embryonic spinal cord NSPCs were cultured in vitro. Lentivirus-mediated Bclaf1 knockdown was conducted. After Bclaf1 knockdown, NSPC apoptosis and proliferation were measured by Annexin V staining and Ki67 staining, respectively. NSPC self-renewal was analyzed by the serial passage assay. NSPC multipotentcy was evaluated by the NSPC differentiation assay. The expression of molecules key to NSPC proliferation and differentiation was measured by real-time RT-PCR and Immunoblotting. Respectively.
Results
BCLAF1 knockdown inhibited NSPC proliferation but enhanced NSPC self-renewal. BCLAF1 knockdown significantly down-regulated the protein levels of Cyclin D1 and Cyclin E1 in NSPCs. Furthermore, BCLAF1 knockdown abrogated the activation of mammalian target of rapamycin complex 1 (mTORC1) via decreasing the transcript levels of mammalian target of rapamycin (mTOR) and regulatory-associated protein of mammalian target of rapamycin (Raptor). The mTOR activator MHY1485 partially restored NSPC proliferation. However, BCLAF1 seemed not to affect NSPC differentiation into neurons and astroglia.
Conclusions
BCLAF1 promotes spinal cord NSPC proliferation but inhibits spinal cord NSPC self-renewal through enhancing the mTORC1 signaling.
Investigation of Tribological Behaviour of AA-6063 Cast Using In-Situ Microwave Process By Taguchi Method & ANFIS Model
Authors: Gangwar Vaibhav , Kumar Sudhir , Singh Hari
Published: August 2022

Tribological behaviour of AA-6063 casted by microwave casting process was investigated. In this present work, sliding wear analysis has done on in-situ cast developed through the novel technique. The in-situ cast of AA-6063 was developed using microwave irradiation. Sliding wear variables like normal load, sliding velocity and sliding distance are optimized through Taguchi technique. L9 orthogonal array and signal-to-noise analysis is used to obtain the optimum process parameter for wear rate (WR) as the selected response. After development, validation tests were performed using variance analysis (ANOVA). The addition of this electron scanning (SEM) microscope, scattering X-ray spectroscopy (EDX) images and the friction characteristics was done to study the wear rate. The adaptive neuro-fuzzy inference device (ANFIS) model changed into evolved the use of test information and re-evaluated the use of an aging level for wear rate.
Societal movement restrictions and adverse mental health outcomes
Authors: Chan Ho Fai , Cheng Zhiming , Mendolia Silvia , Paloyo Alfredo , Tani Massimiliano , Proulx Damon , Savage David , Torgler Benno
Published: August 2022

During the COVID-19 pandemic, governments struggled to find the right balance between re-strictive measures to contain the spread of the virus, and the effects of these measures on people’s psychological wellbeing. This paper investigates the relationship between limitations to mobility and mental health for the UK population during the COVID-19 pandemic, using a unique combination of high-frequency mobility data from Google and longitudinal monthly survey data collected during the pandemic. We find a strong and robust correlation between high-frequency mobility data and established low-frequency mental health survey data. We show that increased residential stationarity predicts a mental wellbeing deterioration even when we control for regional COVID-19 prevalence and lockdown stringency. We uncover heterogeneity in this relationship. Particularly high levels of distress are seen in young, healthy people living alone with an active working life. Women also suffer more from mobility restrictions than men, especially if they have young children.
On n-quasi-(m, q)-isometric operators on a Banach space
Authors: Gherairi Khadija
Published: August 2022

In this paper, we introduce the class of n-quasi-m-isometric operators on a Banach space. Such a class seems to be a natural generalization of m-isometric operators on Banach spaces and of n-quasi-m-isometric operators on Hilbert spaces. We start by giving some of their elementary properties, studying the products and the power of such operators. Next, we will explain the relation between C0-semigroups, n-quasi-(m, q)-isometric operators and (m, q)-isometric operators. Finally, we focus on the dynamic of an n-quasi-m-isometry. More precisely, we prove a result characterizing the supercyclicity of such a class.
Roles of salicylic acid in selenium-enhanced salt tolerance in tomato plants
Authors: Guo Jia , Wu Hong , Fan Shuya , Gong Haijun
Published: August 2022

Aims
Selenium (Se) has been reported to mitigate the harmful effect of salt stress on plants, however the internal mechanisms are still unknown. Here, the effects of Se supplementation on tomato under salt stress were investigated.
Methods
The biomass, relative electrical conductivity (REC), relative water content (RWC), malondialdehyde (MDA), soluble sugar and proline content, and the regulation of plant hormones of Se application in tomato were investigated after exposure to Se and salt stress treatments.
Results
Exogenous Se application improved photosynthesis and the water use efficiency (WUE) of tomato plants under salt stress, thereby promoting the growth of tomato plants under salt stress. Se supplementation also reduced the REC and MDA, decreased the content of H2O2 and O2•−, and mitigated the oxidative damage caused by salt stress. Exogenous Se increased the salicylic acid (SA) content in tomato leaves and roots via up-regulating the PAL or ICS pathways of SA biosynthesis. After pretreatment with the SA inhibitor (ABT), the photosynthetic efficiency of tomato plants decreased, the growth was weakened, and the relative electrical conductivity was increased, indicating that the alleviating role of Se on salt stress was abolished.
Conclusions
Our results clarified the roles of Se and its regulation mechanisms in plant salt stress tolerance, as well as the critical involvement of SA in this process. The study of Se in plant abiotic stress tolerance will give more theoretical foundation for the usage of exogenous Se in agricultural production to enhance the crop growth and yield under adversity stresses.
Preoperative simulation using 3D-CT angiography in splenic flexure colon cancer: a retrospective observational study
Authors: Kawashima Jun , Yamagishi Shigeru , Mori Koichi
Published: August 2022

Purpose: This study aimed to evaluate the extent of lymph node dissection (LND) determined using preoperative Three-dimensional computed tomography angiography (3D-CTA), in the management of splenic flexure colon cancer (SFC).Methods: In this retrospective observational study, sixty patients who underwent preoperative 3D-CTA and laparoscopic complete mesocolic excision for SFC between September 2012 and December 2021 were identified at a tertiary care center in Japan. Preoperative 3D-CTA was used to confirm the feeding arteries, following which the extent of LND was determined. Left hemicolectomy (LHC) was performed in cases requiring LND in the domains of the middle colic artery and left colic artery. In other cases, a partial colectomy (PC) that was defined as a segmental resection of the splenic flexure with LND in the domains of the feeding arterie(s) was performed. Surgical and oncological outcomes were compared between PC and LHC.Results: Preoperative 3D-CTA enabled the evaluation of the feeding artery in all patients. PC was performed in 51 patients (85.0%). Patients who underwent PC had a shorter operating time (P=0.04) and lesser blood loss (P=0.02). There was no difference in complications between the two groups. The number of harvested lymph nodes was lower in the PC group (P=0.008); however, the number of metastatic lymph nodes was comparable. There was no significant difference in the 3-year overall survival, as well as the 3-year disease free survival.Conclusions: Preoperative simulation using 3D-CTA has the potential to be useful in the identification of feeding arteries and determination of optimal extent of LND.Trial registration: The trial was registered with the UMIN Clinical Trials Registry, number UMIN000047600.
P2X4 receptor signaling enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice
Authors: Yoshida Kazuki , Tanihara Shota , Miyashita Yuki , Obayashi Kosuke , Ito Masa-aki , Yamamoto Kimiko , Imai Toshiyashu , Matsuoka Isao
Published: August 2022

Pseudoallergies caused by drugs make disease treatment difficult. Mas-relate G protein-coupled receptor X2 (MRGPRX2), which is specifically expressed in mast cells (MCs), has been implicated in pseudoallergies. High concentrations of therapeutic agents are typically required to stimulate MRGPRX2. Although regulatory mechanisms may enhance this response, the factors involved in this regulation are not well-understood. In this study, the effects of extracellular ATP on MC activation induced by MrgprB2, the mouse ortholog of human MRGPRX2, were examined in mouse peritoneal MCs (PMCs). ATP alone induced minimal PMC degranulation but markedly enhanced degranulation induced by the MrgprB2 agonist compound 48/80 (CP48/80), substance P, PAMP-12, and vancomycin. ATP promoted CP48/80-induced increase in intracellular Ca2+ in PMCs. This enhancement effect of ATP was absent in PMCs prepared from P2X4 receptor (P2X4R)-deficient mice and inhibited by the PI3K inhibitor wortmannin. In addition, P2X4R deficiency reduced the skin-specific and systemic anaphylactic responses to CP48/80 in vivo. In MC-deficient KitW-sh/W-sh mice, reconstitution with MCs obtained from wild-type mice led to a more severe anaphylactic response to CP48/80 compared to that in P2X4R-deficient mice. P2X4R signaling may be involved in MrgprB2-mediated MC activation and is a potential target for alleviating pseudoallergic reactions.
Impact of Physical Activity on Postural Stability and Coordination in Children With Posterior Fossa Tumor: Randomized Control Phase III Trial
Authors: Usama Mahmoud , Abdelaziem Faten , Rashed Wafaa M. , Maher Eslam , Beltagy Mohamed El , Zekri Wael
Published: August 2022

Background: Posterior fossa tumor is a type of brain tumor that is located at the borders of both the brain stem and cerebellum. The cerebellum is the brain region in charge of balance and coordination. Pediatric patients diagnosed with posterior fossa tumor have been reported to fall frequently.Purpose: The aim of this study is to investigate the effectiveness of balance and coordination training in these children.Methods: This randomized control clinical trial (ClinicalTrials.gov Identifier: NCT04528316) was carried out between September 2020 and April 2021 at Children’s Cancer Hospital-57357. The inclusion criteria were - patients with posterior fossa tumor in maintenance phase and, age between 5-12 years. The exclusion criteria were - patients who had a genetic disorder or suffer from mental retardation, a chronic lung disease, sever cardiomyopathy, or a neuromuscular disease that doesn’t not related to tumor. The study participants were randomly assigned into three groups: Group I/Control group: they received Pilates core stability exercises program, Group II/Postural stability group: They received the same program plus HUMAC balance program, and Group III/Coordination group: They received the same program plus coordination exercises of BOT-2. The semi-parametric proportional odds model was used to compare follow up scores of the Postural stability group vs Control, and Coordination group vs Control, while adjusting for baseline values. All tests were two-sided, with alpha set to 0.05.​Results: Sixty children including 38 boys and 22 girls were enrolled in this study. In all three groups, postural stability and coordination improved significantly in terms of modified clinical test of sensory integration of balance, center of pressure, limits of stability, bilateral coordination, and upper-limb coordination.Conclusion: The current study supports the value of adding postural stability and coordination training to the physiotherapy plan for children with posterior fossa tumor.Trial registration number and date of registration: ClinicalTrials.gov Identifier: NCT04528316 on August 27, 2020
Compound odontoma of the lower mandible associated with a deep impacted canine: case report and histologic examination
Authors: MORANDI Benedetta , ALBERTI Alice , TASCHIERI Silvio , SAVADORI Paolo , FRANCETTI Luca , CORBELLA Stefano , FERRIERI Giovanni
Published: August 2022

Even if odontomas are one of the most frequent odontogenic tumors of the oral cavity. no clinical guidelines have been developed to help the clinicians decide in which specific situations the excision of the lesion may be considered beneficial. In this case report a 16 years old male presenting with a compound odontoma and a deep impacted canine has been treated in two different stages: enucleation with histologic examination of the lesion and then extraction of the canine. We highlighted the importance of an early diagnosis, firstly to prevent the odontoma from increasing in size that could complicate the surgical excision, secondly to avoid the compromising of the impacted tooth, serious orthodontic disturbance or jaw distortions.
The significance of presepsin in chronic kidney disease with sepsis
Authors: Wang Wenjuan , He Qingjian , Yuan Jing , Zhang Xiao-Dong , Li Jun-Lu , Zheng Fu-Wen , Kang Jian
Published: August 2022

Background: CKD has a high global prevalence with a consistent estimated global CKD prevalence of between 11 to 13% with the majority stage 3. Patients with CKD undergoing hemodialysis have low immunity and are prone to sepsis. Presepsin is a highly specific biomarker for the early diagnosis of sepsis because presepsin is increased in the blood in the early phase of infection and may be a helpful and valuable biomarker in early diagnosis of sepsis. Therefore, presepsin may have application for the early diagnosis of sepsis in patients with CKD.Purpose This prospective study evaluated the diagnostic value of serum presepsin (soluble CD14-ST) levels for sepsis in chronic kidney disease (CKD) and the influence of undergoing hemodialysis on serum presepsin Methods: This study included 291 patients with CKD and 101 patients with normal renal function and sepsis. Presepsin levels were increased in patients with CKD with or without sepsis or hemodialysis compared to controls, and were highest in patients with CKD and sepsis undergoing hemodialysis. Results: Presepsin levels were similar in patients with CKD with sepsis and no hemodialysis and patients with normal renal function and sepsis, but these levels were lower than in patients with CKD without sepsis undergoing hemodialysis. Presepsin, procalcitonin (PCT) and C-reactive protein (CRP) levels had diagnostic value for sepsis; however, presepsin was a better predictor of sepsis than PCT or CRP in patients with CKD not undergoing hemodialysis. Presepsin level had limited diagnostic value for sepsis in patients with CKD undergoing hemodialysis. In CKD complicated with sepsis, presepsin level was significantly correlated with CRP level, Sequential Organ Failure Assessment score, partial pressure of oxygen and body temperature; there was no correlation between presepsin level and these indicators in CKD without sepsis. Conclusion: These findings suggest physicians should incorporate information on biomarkers with medical history, clinical symptoms, physical signs, and other tests related to sepsis for its diagnosis in patients with CKD undergoing hemodialysis. Presepsin was a better predictor of sepsis in patients with CKD not undergoing hemodialysis.
Copper Adorned Magnetic Nanoparticles as a Heterogeneous Catalyst for Sonogashira Coupling Reaction in Aqueous Media
Authors: Sheikh Safoora , Nasseri Mohammad Ali , Allahresani Ali , Varma Rajender S
Published: August 2022

A nanomagnetic hydrophilic heterogeneous copper catalyst, termed γ-Fe2O3@PEG@PAMAM G0-Cu, has been successfully prepared and characterized using FT–IR, XRD, FE-SEM, TEM, EDX, mapping, TGA/DTG, VSM and ICP analyses. The catalyst displayed excellent activity for the palladium-free Sonogashira cross coupling reaction of various aryl iodides and bromides with phenylacetylene derivatives in pure water. The presence of polyethylene glycol coupled with hydrophilic character of the Cu-catalyst adorned on γ-Fe2O3 MNPs provides the ready dispersion of the catalyst particles in water, leading to higher catalytic performance as well as facile catalyst recovery via simple magnetic decantation. The recovered catalyst was reused for at least six successive runs with little reduction in its catalytic activity and any noticeable changes in its structure. The use of water as a green solvent, without requiring any additive or organic solvent, as well as the exploitation of abundant and low-cost copper catalyst instead of expensive Pd catalyst along with the catalyst recovery and scalability, make this method favorable from environmental and economic points of view for the Sonogashira coupling reaction.