bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of rwanda power system protection in power blackouts and cascading events
Authors: Ntambara Boniface , Umuhoza Ritha
Published: October 2022

Rwanda's power system security is the most important in optimization of grid frequency to prevent power blackouts caused by load disturbances and power imbalances. To manually stabilize and restore network frequency, a tuned PID (Proportional, Integral, and Derivative) controller was used, but it was inefficient and unreliable. The objective of this article is to develop a system that can be used to balance generation—demand powers during power outages by alleviating grid frequency in load disturbance cascaded events. By balancing power generation and demand, the balanced steady-state approach was proposed and developed to restore and optimize grid frequency to its normal state. This technique used PID-Power System Automatic Stabilization (PID-PSAS) technique based on load frequency control. The load disturbances of ± 20%, ± 10%, and ± 5% of a 250 MW power load were considered. MATLAB/Simulink was utilized to model and simulate the Rwanda power and controller systems. The results showed that the frequency responses of single and two area western and northern grids were reduced to $${13*10}^{-5}$$

13

∗
10

-
5

Hz, $${15*10}^{-6}$$

15

∗
10

-
6

Hz, and 0.251 s for overshoot, steady-state error, and settling time respectively. The proposed control system performance of 99.86% success rate was achieved and compared with the current control techniques of 70.6% performance rate. A stable frequency was observed at any disturbances and more than 300 megawatt losses were mitigated. Finally, the developed control technique rapidly stabilize the frequency and balance the generation-demand powers after 0.251 s. Future works have to focus on 0 Hz of steady state errors using cyber-physical power optimization systems.

Article Highlights

The steadiness of connected loads and power utility supply

Reduction of frequency instability and stead-state values

Prevention and mitigation of power blackouts and power interruptions
Evacuee Cinema
Authors: Siddique Salma
Published: October 2022

This new history of partition and South Asian cinema is narrated through the careers of émigré film personnel, as well as through the distinctive genres and ancillary ventures that accompanied the aftershocks of partition. Moving beyond arguments about social contingency and political intent, the book suggests that the creative energies, production and subsequent circulation of popular cinema can offer fresh insights into partition. Pointing to regional connections across national boundaries, this book asserts that the cinemas of India and Pakistan must be explored in tandem to uncover the legacy of partition for the culture industries of the region, one that is not hewn out of national erasures. The leitmotifs of émigré personnel, gossip and satire in film print culture, the partisan repertoire of a theatre company, the film genres of the Muslim social, romantic comedies and charba (remakes), and the unruly film archives of postcolonial nation–states, when accessed through the lens of a divisive decolonization, reveal the parallaxes and confabulations of the 'national' on both sides.
The Connections World
Authors: Commander Simon , Estrin Saul
Published: October 2022

A central feature of modern Asia that trumps differences in economic and political systems is the web of close relationships running between and within business and politics; the connections world. These networks facilitate highly transactional interactions yielding significant reciprocal benefits. Although the connections world has not as yet seriously impeded Asia's economic renaissance, it comes with significant costs and fallibilities. These include the creation and entrenchment of huge market power and the attenuation of competition. They in turn hold back the growth in productivity and innovation that will be essential for further development. The connections world also breeds massive inequalities that may culminate in political instability. The authors argue that if Asia's claim to the 21st century is not to be derailed, major changes must be made to policy and behaviour so as to cut away the foundations of the connections world and promote more sustainable economic and political systems.
Demystifying the proliferation of online peer-to-peer lending in Indonesia: Decoding fintech as a regulatory challenge
Authors: Tan David
Published: October 2022

This paper purports to study the enormous proliferation of fintech online peer-to-peer (P2P) lending in Indonesia, along with their risks and the prevailing regulations of fintech online P2P lending. This article also suggests a varied spectrum of regulatory actions for regulating online P2P lending as an approach to increase consumer protection and stimulate the growth of Indonesia’s financial inclusion. It highlights the regulative risks and challenges of fintech online P2P lending in Indonesia and has discovered various spectra of regulatory responses that the Indonesian government can practise to regulate this potential industry. Solid recommendations were also given to regulators to better develop the present regulatory framework. This paper adds to the literature on the prevailing practice of online P2P lending by offering a legal outlook involving legal protection and the newly emerging fintech industry from an Indonesian context.
The contemporaneous epidemic of chronic, copper deficiency
Authors: Klevay Leslie M.
Published: October 2022

The classical deficiency diseases have nearly disappeared from the industrialised world and are thought to be found largely in sub-Saharan Africa and South Asia. More than 80 collected medical articles, mostly from Europe and North America, describe more than 9000 people with low concentrations of copper in organs or tissues or impaired metabolic pathways dependent on copper. More than a dozen articles reveal improved anatomy, chemistry or physiology in more than 1000 patients from supplements containing copper. These criteria are diagnostic of deficiency according to The Oxford Textbook of Medicine. Alzheimer's disease, ischaemic heart disease and osteoporosis receive major emphasis here. However, impaired vision, myelodysplastic syndrome and peripheral neuropathy are mentioned. Copper deficiency probably causes some common, contemporaneous diseases. Advice is provided about opportunities for research. Seemingly authoritative statements concerning the rarity of nutritional deficiency in developed countries are wrong.
A new species ofHirnantia(Orthida, Brachiopoda) and its implications for the Hirnantian age of the Ellis Bay Formation, Anticosti Island, eastern Canada
Authors: Zimmt Joshua B. , Jin Jisuo
Published: October 2022

Anticosti Island, eastern Canada, records an exceptionally thick and well-exposed Ordovician/Silurian boundary section that hosts a series of diverse marine invertebrate faunas across the Late Ordovician mass extinction. However, the base of the terminal Ordovician stage, the Hirnantian, has been difficult to identify on Anticosti due to the lack of a traditionalHirnantiafauna within the Upper Ordovician Ellis Bay Formation. Previously, the eponymous taxon of theHirnantiafauna, and type species of the genusHirnantia,H. sagittifera(M'Coy, 1851) has been reported only from the uppermost Ellis Bay Formation, leading to uncertainty as to the age of the lower Ellis Bay Formation. Here we reportHirnantia notiskuanin. sp. from the lowermost Ellis Bay Formation. This new species is similar to the type species,H. sagittifera, but is distinguished by its strongly dorsibiconvex shell in mature forms and variously developed uniplicate anterior commissure. Occurrences of these two similar species ofHirnantia,H. notiskuaniandH. sagittifera, within the lower and uppermost Ellis Bay Formation, respectively, indicate a Hirnantian age for the entire Ellis Bay Formation, a finding that is supported by recent palynological and chemostratigraphic studies. Brachiopod assemblages within the Ellis Bay Formation therefore are best characterized as a unique and diverseHirnantiafauna, consisting of genera from both the typicalHirnantiafauna and the epeiric seas of Laurentia.

UUID:http://zoobank.org/1c1dff6a-ee38-4cd3-b8bd-3d803a2774ef
CONSISTENT SPECIFICATION TESTING UNDER SPATIAL DEPENDENCE
Authors: Gupta Abhimanyu , Qu Xi
Published: October 2022

We propose a series-based nonparametric specification test for a regression function when data are spatially dependent, the “space” being of a general economic or social nature. Dependence can be parametric, parametric with increasing dimension, semiparametric or any combination thereof, thus covering a vast variety of settings. These include spatial error models of varying types and levels of complexity. Under a new smooth spatial dependence condition, our test statistic is asymptotically standard normal. To prove the latter property, we establish a central limit theorem for quadratic forms in linear processes in an increasing dimension setting. Finite sample performance is investigated in a simulation study, with a bootstrap method also justified and illustrated. Empirical examples illustrate the test with real-world data.
Developing Iranian sub-national Primary Health Care Measurement Framework: a study protocol
Authors: Rezapour Ramin , Khosravi Ardeshir , Farahbakhsh Mostafa , Ahmadnezhad Elham , Azami-Aghdash Saber , Tabrizi Jafar Sadegh
Published: October 2022

Background:

Developing an effective system for measurement and improvement of primary health care (PHC) based on the conditions and characteristics of the countries’ health systems is one of the World Health Organization (WHO) recommendations.

Aims:

This study will aim to develop a framework to assess the Iranian sub-national PHC system performance using the WHO measurement framework for PHC.

Methods/designs:

This is a mix-method study with a triangulation design. The Iranian sub-national PHC Measurement Framework (PHCMF) will be developed through a review of the WHO’s PHC measurement conceptual framework (for selecting key performance indicators (KPIs)), literature review (academic database), PHC-related national documents, consultations with national experts, and the Delphi technique for finalizing the framework. The required data for calculating selected KPIs is expected to encompass qualitative and quantitative data. Discussion: Iranian PHC system performance is not measured based on the holistic and scientific framework and international standards. The information obtained from this project will guide managers and policymakers to be aware of the current situation and the success rate of the PHC system in achieving the desired goals, as well as identify strengths and weaknesses of the PHC system and provide the solution to better policy formulation.
The Power of Racial Mapping: Ellsworth Huntington, Immigration, and Eugenics in the Progressive Era
Authors: Lavery Colm
Published: October 2022

Racial mapping during the Progressive Era played into the political narratives of eugenic intervention and immigration restriction. This article argues that the racial cartographic work of the Yale geographer and prolific eugenicist Ellsworth Huntington was both developed within and contributed to this racist milieu. Huntington’s middle-class and educated upbringing, his familial history, and his expertise as a well-travelled geographer all conspired to shape his views on eugenics, race, and immigration. By applying the critical cartographic theories of John Brian Harley, Denis Wood, Heather Winlow, and others, I show that Huntington’s racial maps were a product of his cultural and political environment. The success of a map’s impact was often due to maps being seen as objective depictions of spatial variation. Indeed, for Huntington they performed an essential role in communicating and portraying racial information. But, as I argue, they were susceptible to bias, misunderstanding, and intentional manipulation. I show that Huntington’s maps are not accurate snapshots of reality, but rather cultural texts or rhetorical images intended to create a narrative and convince the reader of a particular subjective point of view.
The use of self-compassion techniques in elite footballers: mistakes as opportunities to learn
Authors: James I. A. , Medea B. , Harding M. , Glover Danny , Carraça B.
Published: October 2022

Mistakes made by players during a game are common in football, and when handled well they provide opportunities to learn and develop skills. However, when there is excessive self-criticism associated with the error, leading to dysfunctional cognitions about the self, there is the potential for a reduction in performance and wellbeing. Self-criticism can serve a number of functions but when it is excessive and undermines a player’s sense of adequacy and self-esteem it can lead to anxiety and depression. The current article explores the use of self-compassion techniques as methods for reducing the potential negative impacts of self-criticism.

This paper is a narrative review of the literature, examining the theory and evidence base associated with the use of self-compassion approaches in sport, particularly football. The article presents protocols used with professional footballers to promote performance and wellbeing.

Key learning aims

(1)

Elite athletes are prone to a range of mistakes and stressors, sport and non-sport related, that they are required to deal with in order to maintain their performance and wellbeing.

(2)

Self-compassion strategies are useful techniques for elite athletes to both help maintain wellbeing and prevent the occurrence of ‘mental health symptoms’.

(3)

Evidence suggests that self-compassion strategies are helpful to footballers, and beneficial protocols have been used in studies with professional footballers.
Inaccessible justice: The violation of Article 13 of the CRPD and the ICC's role in filling the accountability gap
Authors: Vantrees Ashira
Published: October 2022

This article examines how women and girls with disabilities who are survivors of sexual and gender-based violence crimes have a right to access justice under Article 13 of the Convention on the Rights of Persons with Disabilities (CRPD). It explains how the right to access justice requires States to actively address gender and disability stigmas and discriminations that create barriers within justice systems, and how the failure to do so violates the CRPD. Further, the author argues that when a State fails to eliminate such barriers post-armed conflict, the International Criminal Court may then exercise jurisdiction over these crimes in order to raise awareness of crimes against women and girls with disabilities, strengthen domestic justice systems by pressuring States to investigate and prosecute these crimes, and act as a court of last resort for crimes against women and girls with disabilities.
The Role of Boundary Mixing for Diapycnal Oxygen Fluxes in a Stratified Marine System
Authors: Holtermann P. , Pinner O. , Schwefel R. , Umlauf L.
Published: October 2022

Insufficient diapycnal oxygen transport through the halocline is the key reason for the anoxic conditions typically observed in the deeper parts of the Baltic Sea. The variability of turbulent oxygen fluxes through the halocline was investigated seasonally and in space during three cruises (summer, fall, winter). Turbulence dissipation rates and oxygen fluxes showed a pronounced seasonal pattern, with the lowest values during summer. At the basin boundaries, halocline oxygen fluxes increased by an order of magnitude as a result of boundary mixing. A simple box model, distinguishing between interior, intermediate, and boundary regions, was used to extrapolate the locally observed fluxes to the central Baltic Sea. The boundary area, covering less than 23% of the total basin area, contributed more than 80% of the basin‐scale oxygen transport through the halocline. According to this model, the annual oxygen flux through the halocline is of the order of 20–28 Gmol per year.
Decoupled Chinese Loess Plateau Dust Deposition and Asian Aridification at Millennial and Tens of Millennial Timescales
Authors: Peng Fei , Nie Junsheng , Stevens Thomas , Pan Baotian
Published: October 2022

It is generally assumed that increased dust accumulation rate (DAR) on the Chinese Loess Plateau (CLP) is associated with intensified inland Asian aridification. However, the timescales and area that any such association operates over is unclear. In this study, we demonstrate a lack of correlation between the southern CLP loess DAR variations and aridification over the past 130 ka, which does not support a direct link between high DAR and intensified inland Asian aridification over millennial to tens of millennial timescales. Instead, we propose that loess DAR variation is more likely determined by wet‐dry cycles and associated loose sediment production and availability via fluvial and glacial processes.
Changes in IPCC Scenario Assessment Emulators Between SR1.5 and AR6 Unraveled
Authors: Nicholls Z. , Meinshausen M. , Lewis J. , Smith C. J. , Forster P. M. , Fuglestvedt J. S. , Rogelj J. , Kikstra J. S. , Riahi K. , Byers E.
Published: October 2022

The IPCC's scientific assessment of the timing of net‐zero emissions and 2030 emission reduction targets consistent with limiting warming to 1.5°C or 2°C rests on large scenario databases. Updates to this assessment, such as between the IPCC's Special Report on Global Warming of 1.5°C (SR1.5) of warming and the Sixth Assessment Report (AR6), are the result of intertwined, sometimes opaque, factors. Here we isolate one factor: the Earth System Model emulators used to estimate the global warming implications of scenarios. We show that warming projections using AR6‐calibrated emulators are consistent, to within around 0.1°C, with projections made by the emulators used in SR1.5. The consistency is due to two almost compensating changes: the increase in assessed historical warming between SR1.5 (based on AR5) and AR6, and a reduction in projected warming due to improved agreement between the emulators' response to emissions and the assessment to which it is calibrated.
Shear‐Wave Splitting in the Mantle Wedge: Role of Elastic Tensor Symmetry of Olivine Aggregates
Authors: Kenyon L. M. , Wada I.
Published: October 2022

Using a 3‐D mantle wedge flow field for a generic oblique subduction system, we calculate elastic tensors of mineral aggregates in the mantle wedge for A‐, B‐, C‐, and E‐type olivine crystal preferred orientations (CPO) and apply the calculated elastic tensor in the forward calculation of shear‐wave splitting (SWS) through the mantle wedge. We find that the hexagonal approximation of the full tensor does not affect the SWS parameters (the fast direction and the delay time) significantly for all CPO types except that the delay time for C‐type CPO becomes shorter. Additionally, we find that despite the 3‐D mantle flow field that results from oblique subduction, the fast direction is margin‐normal for A‐, C‐ and E‐type CPOs and margin‐parallel for B‐type CPO.
Ultracompact topological photonic switch based on valley-vortex-enhanced high-efficiency phase shift
Authors: Wang Hongwei , Tang Guojing , He Yu , Wang Zhen , Li Xingfeng , Sun Lu , Zhang Yong , Yuan Luqi , Dong Jianwen , Su Yikai
Published: October 2022

Topologically protected edge states based on valley photonic crystals (VPCs) have been widely studied, from theoretical verification to technical applications. However, research on integrated tuneable topological devices is still lacking. Here, we study the phase-shifting theory of topological edge modes based on a VPC structure. Benefiting from the phase vortex formed by the VPC structure, the optical path of the topological edge mode in the propagation direction is approximately two-fold that of the conventional optical mode in a strip waveguide. In experiments, we show a 1.57-fold improvement in π-phase tuning efficiency. By leveraging the high-efficiency phase-shifting properties and the sharp-turn features of the topological waveguide, we demonstrate an ultracompact 1 × 2 thermo-optic topological switch (TOTS) operating at telecommunication wavelengths. A switching power of 18.2 mW is needed with an ultracompact device footprint of 25.66 × 28.3 μm in the wavelength range of 1530–1582 nm. To the best of our knowledge, this topological photonic switch is the smallest switch of any dielectric or semiconductor 1 × 2/2 × 2 broadband optical switches, including thermo-optic and electro-optic switches. In addition, a high-speed transmission experiment employing the proposed TOTS is carried out to demonstrate the robust transmission of high-speed data. Our work reveals the phase-shifting mechanism of valley edge modes, which may enable diverse topological functional devices in many fields, such as optical communications, nanophotonics, and quantum information processing.
Age-linked suppression of lipoxin A4 associates with cognitive deficits in mice and humans
Authors: Pamplona Fabricio A. , Vitória Gabriela , Sudo Felipe K. , Ribeiro Felipe C. , Isaac Alinny R. , Moraes Carolina A. , Chauvet Mariana G. , Ledur Pitia Flores , Karmirian Karina , Ornelas Isis M. , Leo Luciana M. , Paulsen Bruna , Coutinho Gabriel , Drummond Claudia , Assunção Naima , Vanderborght Bart , Canetti Claudio A. , Castro-Faria-Neto Hugo C. , Mattos Paulo , Ferreira Sergio T. , Rehen Stevens K. , Bozza Fernando A. , Lourenco Mychael V. , Tovar-Moll Fernanda
Published: October 2022

Age increases the risk for cognitive impairment and is the single major risk factor for Alzheimer’s disease (AD), the most prevalent form of dementia in the elderly. The pathophysiological processes triggered by aging that render the brain vulnerable to dementia involve, at least in part, changes in inflammatory mediators. Here we show that lipoxin A4 (LXA4), a lipid mediator of inflammation resolution known to stimulate endocannabinoid signaling in the brain, is reduced in the aging central nervous system. We demonstrate that genetic suppression of 5-lipoxygenase (5-LOX), the enzyme mediating LXA4 synthesis, promotes learning impairment in mice. Conversely, administration of exogenous LXA4 attenuated cytokine production and memory loss induced by inflammation in mice. We further show that cerebrospinal fluid LXA4 is reduced in patients with dementia and positively associated with cognitive performance, brain-derived neurotrophic factor (BDNF), and AD-linked amyloid-β. Our findings suggest that reduced LXA4 levels may lead to vulnerability to age-related cognitive disorders and that promoting LXA4 signaling may comprise an effective strategy to prevent early cognitive decline in AD.
The schemes, mechanisms and molecular pathway changes of Tumor Treating Fields (TTFields) alone or in combination with radiotherapy and chemotherapy
Authors: Tanzhu Guilong , Chen Liu , Xiao Gang , Shi Wen , Peng Haiqin , Chen Dikang , Zhou Rongrong
Published: October 2022

Tumor Treating Fields (TTFields) is a physical therapy that uses moderate frequency (100–300 kHz) and low-intensity (1–3 V/cm) alternating electric fields to inhibit tumors. Currently, the Food and Drug Administration approves TTFields for treating recurrent or newly diagnosed glioblastoma (GBM) and malignant pleural mesothelioma (MPM). The classical mechanism of TTFields is mitotic inhibition by hindering the formation of tubulin and spindle. In addition, TTFields inhibits cell proliferation, invasion, migration and induces cell death, such as apoptosis, autophagy, pyroptosis, and cell cycle arrest. Meanwhile, it regulates immune function and changes the permeability of the nuclear membrane, cell membrane, and blood-brain barrier. Based on the current researches on TTFields in various tumors, this review comprehensively summarizes the in-vitro effects, changes in pathways and molecules corresponding to relevant parameters of TTFields (frequency, intensity, and duration). In addition, radiotherapy and chemotherapy are common tumor treatments. Thus, we also pay attention to the sequence and dose when TTFields combined with radiotherapy or chemotherapy. TTFields has inhibitory effects in a variety of tumors. The study of TTFields mechanism is conducive to subsequent research. How to combine common tumor therapy such as radiotherapy and chemotherapy to obtain the maximum benefit is also a problem that’s worthy of our attention.
Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming
Authors: Chong Danyang , Gu Yayun , Zhang Tongyu , Xu Yu , Bu Dandan , Chen Zhong , Xu Na , Li Liangkui , Zhu Xiyu , Wang Haiquan , Li Yangqing , Zheng Feng , Wang Dongjin , Li Peng , Xu Li , Hu Zhibin , Li Chaojun
Published: October 2022

Neonatal heart undergoes metabolic conversion and cell cycle arrest preparing for the increased workload during adulthood. Herein, we report that neonatal ketone body elevation is a critical regulatory factor for postnatal heart development. Through multiomics screening, we found that the expression of 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), the rate-limiting enzyme of ketogenesis, was transiently induced by colostrum in the neonatal heart. Hmgcs2 knockout caused mitochondrial maturation defects. Meanwhile, postnatal heart development was compromised and cardiomyocytes reacquired proliferation capacity in Hmgcs2 knockout mice. Consequently, over 40% of newborn Hmgcs2 knockout mice died before weaning. The heart function of surviving Hmgcs2 knockout mice was also impaired, which could be rescued by ketone body supplementation during the suckling stage. Mechanistically, ketone body deficiency inhibited β-hydroxybutyrylation but enhanced acetylation of mitochondrial proteins, which might be responsible for the inhibition of the enzyme activity in mitochondria. These observations suggest that ketone body is critical for postnatal heart development through regulating mitochondrial maturation and metabolic reprogramming.
Independent origin of large labyrinth size in turtles
Authors: Evers Serjoscha W. , Joyce Walter G. , Choiniere Jonah N. , Ferreira Gabriel S. , Foth Christian , Hermanson Guilherme , Yi Hongyu , Johnson Catherine M. , Werneburg Ingmar , Benson Roger B. J.
Published: October 2022

The labyrinth of the vertebrate inner ear is a sensory system that governs the perception of head rotations. Central hypotheses predict that labyrinth shape and size are related to ecological adaptations, but this is under debate and has rarely been tested outside of mammals. We analyze the evolution of labyrinth morphology and its ecological drivers in living and fossil turtles, an understudied group that underwent multiple locomotory transitions during 230 million years of evolution. We show that turtles have unexpectedly large labyrinths that evolved during the origin of aquatic habits. Turtle labyrinths are relatively larger than those of mammals, and comparable to many birds, undermining the hypothesis that labyrinth size correlates directly with agility across vertebrates. We also find that labyrinth shape variation does not correlate with ecology in turtles, undermining the widespread expectation that reptilian labyrinth shapes convey behavioral signal, and demonstrating the importance of understudied groups, like turtles.
Observing ground-state properties of the Fermi-Hubbard model using a scalable algorithm on a quantum computer
Authors: Stanisic Stasja , Bosse Jan Lukas , Gambetta Filippo Maria , Santos Raul A. , Mruczkiewicz Wojciech , O’Brien Thomas E. , Ostby Eric , Montanaro Ashley
Published: October 2022

The famous, yet unsolved, Fermi-Hubbard model for strongly-correlated electronic systems is a prominent target for quantum computers. However, accurately representing the Fermi-Hubbard ground state for large instances may be beyond the reach of near-term quantum hardware. Here we show experimentally that an efficient, low-depth variational quantum algorithm with few parameters can reproduce important qualitative features of medium-size instances of the Fermi-Hubbard model. We address 1 × 8 and 2 × 4 instances on 16 qubits on a superconducting quantum processor, substantially larger than previous work based on less scalable compression techniques, and going beyond the family of 1D Fermi-Hubbard instances, which are solvable classically. Consistent with predictions for the ground state, we observe the onset of the metal-insulator transition and Friedel oscillations in 1D, and antiferromagnetic order in both 1D and 2D. We use a variety of error-mitigation techniques, including symmetries of the Fermi-Hubbard model and a recently developed technique tailored to simulating fermionic systems. We also introduce a new variational optimisation algorithm based on iterative Bayesian updates of a local surrogate model.
Quantized topological pumping of solitons in nonlinear photonics and ultracold atomic mixtures
Authors: Mostaan Nader , Grusdt Fabian , Goldman Nathan
Published: October 2022

Exploring the interplay between topological band structures and tunable nonlinearities has become possible with the development of synthetic lattice systems. In this emerging field of nonlinear topological physics, an experiment revealed the quantized motion of solitons in Thouless pumps and suggested that this phenomenon was dictated by the Chern number of the band from which solitons emanate. Here, we elucidate the origin of this nonlinear topological effect, by showing that the motion of solitons is established by the quantized displacement of the underlying Wannier functions. Our general theoretical approach, which fully clarifies the central role of the Chern number in solitonic pumps, provides a framework for describing the topological transport of nonlinear excitations in a broad class of physical systems. Exploiting this interdisciplinarity, we introduce an interaction-induced topological pump for ultracold atomic mixtures, where solitons of impurity atoms experience a quantized drift resulting from genuine interaction processes with their environment.
Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications
Authors: Albert C. , Bracaglia L. , Koide A. , DiRito J. , Lysyy T. , Harkins L. , Edwards C. , Richfield O. , Grundler J. , Zhou K. , Denbaum E. , Ketavarapu G. , Hattori T. , Perincheri S. , Langford J. , Feizi A. , Haakinson D. , Hosgood S. A. , Nicholson M. L. , Pober J. S. , Saltzman W. M. , Koide S. , Tietjen G. T.
Published: October 2022

Vascular endothelial cells (ECs) play a central role in the pathophysiology of many diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could dramatically improve efficacy by providing elevated and sustained intracellular drug levels. However, achieving sufficient levels of NP targeting in human settings remains elusive. Here, we overcome this barrier by engineering a monobody adapter that presents antibodies on the NP surface in a manner that fully preserves their antigen-binding function. This system improves targeting efficacy in cultured ECs under flow by >1000-fold over conventional antibody immobilization using amine coupling and enables robust delivery of NPs to the ECs of human kidneys undergoing ex vivo perfusion, a clinical setting used for organ transplant. Our monobody adapter also enables a simple plug-and-play capacity that facilitates the evaluation of a diverse array of targeted NPs. This technology has the potential to simplify and possibly accelerate both the development and clinical translation of EC-targeted nanomedicines.
Evolution and modulation of antigen-specific T cell responses in melanoma patients
Authors: Huuhtanen Jani , Chen Liang , Jokinen Emmi , Kasanen Henna , Lönnberg Tapio , Kreutzman Anna , Peltola Katriina , Hernberg Micaela , Wang Chunlin , Yee Cassian , Lähdesmäki Harri , Davis Mark M. , Mustjoki Satu
Published: October 2022

Analyzing antigen-specific T cell responses at scale has been challenging. Here, we analyze three types of T cell receptor (TCR) repertoire data (antigen-specific TCRs, TCR-repertoire, and single-cell RNA + TCRαβ-sequencing data) from 515 patients with primary or metastatic melanoma and compare it to 783 healthy controls. Although melanoma-associated antigen (MAA) -specific TCRs are restricted to individuals, they share sequence similarities that allow us to build classifiers for predicting anti-MAA T cells. The frequency of anti-MAA T cells distinguishes melanoma patients from healthy and predicts metastatic recurrence from primary melanoma. Anti-MAA T cells have stem-like properties and frequent interactions with regulatory T cells and tumor cells via Galectin9-TIM3 and PVR-TIGIT -axes, respectively. In the responding patients, the number of expanded anti-MAA clones are higher after the anti-PD1(+anti-CTLA4) therapy and the exhaustion phenotype is rescued. Our systems immunology approach paves the way for understanding antigen-specific responses in human disorders.
Biological invasions as a selective filter driving behavioral divergence
Authors: Chapple David G. , Naimo Annalise C. , Brand Jack A. , Michelangeli Marcus , Martin Jake M. , Goulet Celine T. , Brunton Dianne H. , Sih Andrew , Wong Bob B. M.
Published: October 2022

Biological invasions are a multi-stage process (i.e., transport, introduction, establishment, spread), with each stage potentially acting as a selective filter on traits associated with invasion success. Behavior (e.g., exploration, activity, boldness) plays a key role in facilitating species introductions, but whether invasion acts as a selective filter on such traits is not well known. Here we capitalize on the well-characterized introduction of an invasive lizard (Lampropholis delicata) across three independent lineages throughout the Pacific, and show that invasion shifted behavioral trait means and reduced among-individual variation—two key predictions of the selective filter hypothesis. Moreover, lizards from all three invasive ranges were also more behaviorally plastic (i.e., greater within-individual variation) than their native range counterparts. We provide support for the importance of selective filtering of behavioral traits in a widespread invasion. Given that invasive species are a leading driver of global biodiversity loss, understanding how invasion selects for specific behaviors is critical for improving predictions of the effects of alien species on invaded communities.
Application of microtomography and petrography techniques for the characterization of porosity of synthetic carbonatic rock minerals before and after acidification processes
Authors: Galindo Katia , Lins Cecília , Guimarães Leonardo , Lima Analice , Silva Katarina , Nova Abraão
Published: October 2022

The objective of this work is to physically characterize and analyze synthetic carbonate rocks through microtomography and petrography techniques, focusing on a comparative analysis before and after degradation with a reactive fluid. For this study, physical characterization analysis with computerized microtomography and petrography on the samples before and after the acidification procedure was performed. The petrographic analysis verified an increase in both intergranular and intragranular porosities after dissolution. The microtomography analysis quantified the maximum increase in porosity, from 11.8 to 41.3% in the two-dimensional analysis and 31.6–52% in the three-dimensional analysis of the porous structures. Furthermore, the pores were quantified according to their area, and data was obtained on the orientation of the pores, providing insight into the preferred paths of fluid flow. It was also observed that the microtomography technique was an effective tool for characterizing fractures in the samples before and after dissolution. Such analyses are crucial for the extraction and injection of fluids at high depths due to the mechanical and physical risks arising from the dissolution of minerals as well as changes in pressure, temperature, and saturation, all of which affect the stress state of the reservoir rock.
Higher order chemical reaction effects on $$\text {Cu}{-}\text {H}_2\text {O}$$ nanofluid flow over a vertical plate
Authors: K Padmaja , B Rushi Kumar
Published: October 2022

Many fluids used in industries will possess a uniform velocity acting along with it. Although a few researchers have analyzed the fluid flow along with a constant velocity but such modeling in nanofluids is quite new. The novelty of this work is the numerical evaluation of a nanofluid with a constant velocity through a vertical plate in a porous medium under Dufour as well as Soret impacts coupled with a higher order chemical reaction. A rotating MHD nanofluid is investigated for both heat as well as mass transfer. An incompressible, steady-state fluid is subjected to flow through a semi-infinite plate by taking into account viscous dissipation as well as a magnetic field. Flow equations are typically represented by PDEs that are nonlinear and coupled. The PDEs are changed to ODEs by similarity transformation variables. Runge-Kutta method of $$4{\text {th}}$$

4
th

order accuracy along with shooting technique is employed to solve the converted system of ODEs. $$\text {Cu}{-}\text {H}_2\text {O}$$

Cu
-

H
2

O

is used to provide an in-depth analysis of the examined problem. In order to account for practical considerations, the maximum order of the chemical reaction is limited to 3 and a comparative analysis is provided for $$1{\text {st}}$$

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and $$3{\text {rd}}$$

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order chemical reactions. For different physical quantities, different numerical values that are obtained using MATLAB are used to analyze various properties regarding the flow. Heat transfer, and mass transfer rates are discussed using graphs and tables. Compared to low order chemical reactions, high order chemical reactions allow higher rates at which the reaction takes place, thus allowing greater rates of heat and mass transfer.
Pollinator biological traits and ecological interactions mediate the impacts of mosquito-targeting malathion application
Authors: Kim Dongmin , Burkett-Cadena Nathan D. , Reeves Lawrence E.
Published: October 2022

Mosquito adulticides are perceived by the public as detrimental to nontarget arthropods, contributing to declines of native and beneficial insects. However, the actual impact of adulticides on nontarget arthropods in nature needs to incorporate biological and ecological elements. Here, we investigated the effect of biological/behavioral traits (butterfly roosting at different heights, roosting in sites underneath foliage, bumblebee hive usage) and interactions (parasitism, predation) of pollinators (butterflies and bumblebees) that could mediate the impacts of malathion application in manipulative semi-field experiments in Florida, USA. Roosting height from the spray route had a significant negative relationship with mortality of butterflies treated with ULV malathion, with high survival at the highest roosting height (7 m), but butterflies roosting among vegetation did not have higher survival. Bumblebees with hive access had significantly higher survival than bumblebees without hive access. Host plants treated with ULV malathion significantly reduced parasitism of monarch eggs by Trichogramma platneri, but increased predation of monarch caterpillars by Polistes paper wasps. These data provide insight into the realistic impacts of adulticide applications on pollinators in nature which will enable mosquito control districts to better limit nontarget effects of adulticide treatments and may help to address concerns related to potential nontarget effects.
Synthesis of multi-band reflective polarizing metasurfaces using a generative adversarial network
Authors: Naseri Parinaz , Goussetis George , Fonseca Nelson J. G. , Hum Sean V.
Published: October 2022

Electromagnetic linear-to-circular polarization converters with wide- and multi-band capabilities can simplify antenna systems where circular polarization is required. Multi-band solutions are attractive in satellite communication systems, which commonly have the additional requirement that the sense of polarization is reversed between adjacent bands. However, the design of these structures using conventional ad hoc methods relies heavily on empirical methods. Here, we employ a data-driven approach integrated with a generative adversarial network to explore the design space of the polarizer meta-atom thoroughly. Dual-band and triple-band reflective polarizers with stable performance over incident angles up to and including 30°, corresponding to typical reflector antenna system requirements, are synthesized using the proposed method. The feasibility and performance of the designed polarizer is validated through measurements of a fabricated prototype.
Inclusion of calcium phosphate does not further improve in vitro and in vivo osteogenesis in a novel, highly biocompatible, mechanically stable and 3D printable polymer
Authors: Owji Nazanin , Mandakhbayar Nandin , Cha Jae-Ryung , Padalhin Andrew R. , Erdogan Zalike Keskin , Aldaadaa Alaa , Shakouri Taleen , Sawadkar Prasad , Frost Oliver , Kim Hae-Won , García-Gareta Elena , Knowles Jonathan C.
Published: October 2022

At a time of unpredictable challenges for health, one trend is certain: there is an exceedingly high demand for functional implants, particularly bone grafts. This has encouraged the emergence of bone tissue engineering substitutes as an alternative method to conventional bone grafts. However, the current approaches in the field face several limitations that have prevented the ultimate translation into clinical settings. As a result, many attempts have been made to fabricate synthetic bone implants that can offer suitable biological and mechanical properties.

Light curable methacrylate-based polymers have ideal properties for bone repair. These materials are also suitable for 3D printing which can be applicable for restoration of both function and aesthetics. The main objective of this research was to investigate the role of calcium phosphate (CaP) incorporation in a mechanically stable, biologically functional and 3D printable polymer for the reconstruction of complex craniofacial defects. The experimental work initially involved the synthesis of (((((((((((3R,3aR,6S,6aR)- hexahydrofuro[3,2-b]furan-3,6-diyl)bis(oxy))bis(ethane-2,1- 48 diyl))bis(oxy))bis(carbonyl))bis(azanediyl))bis(3,3,5-trimethylcyclohexane-5,1- 49 diyl))bis(azanediyl))bis(carbonyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) referred to as CSMA and fabrication of composite discs via a Digital Light Printing (DLP) method. The flow behaviour of the polymer as a function of CaP addition, surface remineralisation potential, in vitro cell culture, using MC3T3 and Adipose-Derived Mesenchymal Stem Cells (ADSCs) and ex ovo angiogenic response was assessed. Finally, in vivo studies were carried out to investigate neo-bone formation at 4- and 8-weeks post-implantation. Quantitative micro-CT and histological evaluation did not show a higher rate of bone formation in CaP filled CSMA composites compared to CSMA itself. Therefore, such polymeric systems hold promising features by allowing more flexibility in designing a 3D printed scaffold targeted at the reconstruction of maxillofacial defects.
Changes in plasma fatty acids profile in hyperketonemic ewes during early lactation: a preliminary study
Authors: Lisuzzo Anastasia , Fiore Filippo , Harvatine Kevin , Mazzotta Elisa , Berlanda Michele , Spissu Nicoletta , Badon Tamara , Contiero Barbara , Moscati Livia , Fiore Enrico
Published: October 2022

The transition from late pregnancy to early lactation is characterized by marked changes in energy balance of dairy ruminants. The mobilization of adipose tissue led to an increase in plasma non-esterified fatty acids (NEFA) and β-hydroxybutyrate (BHB). The aim of this study was to analyze the total plasma fatty acids of healthy and hyperketonemic dairy ewes in early lactation through gas chromatography (GC) to evaluate metabolic alterations. An observational study was used with a cross-sectional experimental design. Forty-six Sarda dairy ewes were enrolled in the immediate post-partum (7 ± 3 days in milk) and divided into two groups according to serum BHB concentration: non-hyperketonemic group (n = 28; BHB < 0.86 mmol/L) and hyperketonemic group (n = 18; BHB ≥ 0.86 mmol/L). A two-way ANOVA included the effect of group and parity was used to evaluate differences in fatty acids (FA) concentrations. A total of 34 plasma FA was assessed using GC. 12 out of 34 FA showed a significant different between groups and 3 out of 34 were tended to significance. Only NEFA concentration and stearic acid were influenced by parity. The results may suggest possible links with lipid metabolism, inflammatory and immune responses in hyperketonemic group. In conclusion, GC represents a useful tool in the study of hyperketonemia and primiparous dairy ewes might show a greater risk to develop this condition.
Synthesis and electrochemical performance of α-Al2O3 and M-Al2O4 spinel nanocomposites in hybrid quantum dot-sensitized solar cells
Authors: Mahmoud Sawsan A. , Elsisi Moustafa E. , Mansour Asmaa F.
Published: October 2022

The aim of this study is to describe the performance of the aluminum oxide nanoparticle and metal aluminate spinel nanoparticle as photo-anodes in quantum dot photovoltaic. By using a sol–gel auto combustion method, Al2O3 NPs, CoAl2O4, CuAl2O4, NiAl2O4, and ZnAl2O4 were successfully synthesized. The formation of Al2O3 NPs and MAl2O4 (M=Co, Cu, Ni, Zn) nanocomposite was confirmed by using several characteristics such as XRD, UV–Vis, FTIR, FE-SEM, and EDX spectra. The XRD shows that the CoAl2O4 has a smaller crystallite size (12.37 nm) than CuAl2O4, NiAl2O4, and ZnAl2O4. The formation of a single-phase spinel structure of the calcined samples at 1100 °C was confirmed by FTIR. Our studies showed that the pure Al2O3 NPs have a lower energy gap (1.37 eV) than synthesized MAl2O4 under UV–Vis irradiation. Due to the well separation between the light-generated electrons and the formed holes, the cell containing ZnAl2O4 nanocomposite with CdS QDs has the highest efficiency of 8.22% and the current density of 22.86 mA cm−2, while the cell based on NiAl2O4 as a photoelectrode, six cycles of CdS/ZnS QDs, and P-rGO as a counter electrode achieved the best (PCE) power conversion efficiency of 15.14% and the current density of 28.22 mA cm−2. Electrochemical impedance spectroscopy shows that ZnAl2O4 and NiAl2O4 nanocomposites have the highest life times of the photogenerated electrons (τn) of 11*10−2 and 96*10−3 ms, respectively, and the lowest diffusion rates (Keff) of 9.09 and 10.42 ms−1, respectively.