bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifikasi Desa Sebagai “Lewu Proklim” di Kabupaten Pulang Pisau
Authors: Hukom Alexandra , Muhamad Iqbal Rendy , Nomeritae Nomeritae , Abdurahman Ravenalla
Published: June 2024

Desa Pro Iklim adalah program pemerintah dalam rangka meningkatkan keterlibatan masyarakat dalam melakukan aksi adaptasi dan mitigasi perubahan lingkungan serta penurunan emisi gas rumah kaca. Penelitian ini bertujuan untuk mengidentifikasi Desa yang ada di sepanjang jalan trans Kalimantan dan berada di tepian sungai Kahayan. Jenis penelitian ini adalah penelitian deksriptif dengan menggunakan analisis SWOT, dengan ditemukannya Desa Pilang berdasarkan Pedoman Program Proklim dapat dijadikan sebagai Lewu Proklim. Hasil analisis menunjukan bahwa memperkuat strategi sosialisasi secara intensif untuk memperkenalkan program kampung iklim kepada masyarakat. Adaptasi dengan menambah saluran irigasi, penampungan air hujan dan mengembangkan kebun percontohan yang telah digunakan sebagai pakan orangutan di Konservasi Pelepasliaran Orang Utan. Mitigasi dengan membiasakan masyarakt untuk menggunakan pupuk organik dan menggalakan kegiatan penanaman pohon secara insentif terutama di pesisir Sungai Kahayan. Partisipasi dengan mendayagunakan tokoh masyarakat sebagai panutan dan mengadakan acara adat secara ritual untuk menjalin komunikasi antar warga dan pendekatan budaya dan agama.
Tantangan Pengembangan Ekonomi Hijau di China
Authors: Khaldun Riady Ibnu , Ismira Andi , Pertiwi Dian , Amin Asma
Published: June 2024

Pengembangan ekonomi hijau di China masih sulit untuk diwujudkan sepenuhnya dalam upaya pengaplikasian, kondisi ini dilatarbelakangi oleh perekonomian China yang berkaitan erat dengan industrialisasi dan produksi karbon yang tidak ramah lingkungan. Kegiatan produksi, investasi, dan perluasan ekonomi oleh China menciptakan celah besar antara target ekonomi dan ambisi ekonomi hijau yang diupayakan. Penelitian ini bertujuan untuk mengetahui tantangan serta strategi yang diterapkan oleh China dalam pengembangan ekonomi hijaunya dengan berfokus pada tahun 2016-2020. Konsep yang digunakan pada penelitian adalah green economy, dan industrial development. Konsep tersebut kemudian menjadi pengarah dalam analisis tantangan dan strategi yang diterapkan. Jenis penelitian yang digunakan adalah penelitian deskriptif dengan menggunakan jenis data primer dan sekunder, data didapatkan melalui penelitian mendalam atas fenomena dan wawancara mandiri terkait fenomena ekonomi hijau di China. Ekonomi China sejak awal 2000-an mengalami perubahan mendasar yang berkaitan dengan investasi dan ekstraksi sumber daya. Tantangan dalam negeri yang terdiri dari masalah industralisasi China, pembangunan infrastruktur, penggunaan bahan bakar yang berlebihan, serta demografi China yang turut andil dalam pola konsumsi masyarakat yang memberikan pengaruh besar pada produksi dan konsumsi masyarakat China. Pada skala internasional terdapat tantangan berupa tuntutan pengurangan emisi karbon, dan ekspansi ekonomi China diberbagai negara atau relokasi industri dibeberapa negara.
Pemberdayaan Perempuan dalam Pembangunan Berkelanjutan di Era Revolusi Industri 4.0
Authors: Masruchiyah Nieke , Laratmase Antonia Junianty
Published: June 2024

The world conference on Women in 1995 adopted the Beijing Platform for Action, in which governments agreed to implement gender mainstreaming. Other UN conference also acknowledge the importance of adapting a gender specific approach to implementing policies: gender equality has been identified as one of MDGs and designed as a crosscutting theme for work of the commission on sustainable organizations, national government, and most civil society groups still fail to integrate gender perspective adequately into their policies and their action. Gender equality is a right. Women are not only more affected by economic crisis and lack of health care, to climate change, violence against women and escalating conflicts, but also possess ideas and leadership to solve them. The 2030 Agenda for Sustainable Development and its 17 Sustainable Development Goals (SDGs) adopted by world leaders in 2015. Achieving gender equality and women’s empowerment is integral to each of the 17 goals in economic globalization era. Women must not miss the jobs of the future. This is the central message of a new study on women in science released by UNESCO (11/06/2021). The digital revolution will need to be inclusive. A fundamental transformation is under way in the workforce. The Fourth Industrial Revolution, or Industry 4.0, is disrupting industries and the labor market, as cyber physical systems proliferate and become more sophisticated.  The irony is that the fields most relevant to Industry 4.0 are the very ones where women remain underrepresented in most countries, namely IT, computing, physics, mathematics and engineering. Japan is hoping that the centerpiece of its new growth strategy, Society 5.0, will enable society to adapt to a shrinking, ageing population through widespread use of AI and other digital technologies in industry, agriculture and the services sector.
Pengelolaan Sampah di PT. Sumber Rejeki Medika Jaya Kota Samarinda
Authors: Rahiman Rahiman Agus Salim , Apriani Mellisya Iriena , Salamah Selvi , Iswahyudi Norman , Fauziah Fenty
Published: June 2024

PT. Sumber Rejeki Medika Jaya (PT. SRMJ) merupakan perusahaan swasta nasional yang bergerak di distribusi alat kesehatan, peralatan dental, alat laboratorium, peraga pendidikan dan lainnya. Dalam lingkungan hidup, membangun kesadaran dalam menciptakan dan menjaga kebersihan lingkungan merupakan hal yang penting bagi sebuah perusahaan. Selain itu, kondisi lingkungan yang bersih juga sangat berpengaruh terhadap produktivitas karyawan dan kepuasan pelanggan. Tujuan dari penulisan ini adalah untuk mendapatkan gambaran tentang kesadaran lingkungan dan pengelolaan sampah di PT. Sumber Rejeki Medika Jaya Kota Samarinda. Metode dalam penelitian ini menggunakan pendekatan deskripsi kualitatif dengan melakukan pengamatan langsung dan wawancara untuk mendapatkan data terkait kesadaran lingkungan dan pengelolaan sampah di PT. Sumber Rejeki Medika Jaya Kota Samarinda. Hasil Penilitian ini menyimpulkan bahwa pengelolaan sampah di PT. Sumber Rejeki Medika Jaya Kota Samarinda sudah baik.
Pengaruh Kompetensi dan Motivasi Terhadap Kepuasan Kerja Karyawan Selama Masa Pandemi Covid-19 di PT. Kao Indonesia
Authors: Masruchiyah Nieke , Ratnasih Cicih , Gumay Olivia Augesthania Putri
Published: June 2024

PT KAO Indonesia adalah perusahaan multinasional yang bergerak di bidang manufaktur dan distribusi produk konsumsi yang secara garis besar dikelompokkan dalam 3 kategori sebagai berikut: Health & Beauty, Hygiene & Living dan Baby Diapers. Penelitian ini menggunakan pendekatan kuantitatif dan metode penelitian yang datanya berupa angka dan digunakan untuk mengukur sebuah subjek atau objek penelitian. Penelitian ini dimaksudkan untuk menjelaskan pengaruh kompetensi dan motivasi terhadap kepuasan kerja yang berdampak pada kinerja selama masa pandemi covid-19. Hasil penelitian dari analisis pengaruh langsung maupun tidak langsung pada variabel kompetensi dan motivasi terhadap kepuasan kerja yang berdampak pada kinerja selama masa pandemi covid-19 di PT. KAO Indonesia maka dapat disimpulkan yaitu sebagai berikut : 1. Pada variabel penelitian kompetensi dan motivasi dalam mempengaruhi kinerja dinyatakan bahwa signifikan dengan nilai 0,000  dalam uji simultan F dikatakan dapat mempengaruhi. 2. Variabel Kompetensi memiliki pengaruh positif terhadap kepuasan kerja hal ini dibuktikan dengan tingkat signifikansi dengan nilai 0,000 dan nilai koefisien regresi sebesar 0,367. Hal ini membuktikan bahwa hipotesis pertama diterima. 3. Variabel Motivasi memiliki pengaruh positif terhadap kepuasan kerja hal ini dibuktikan dengan tingkat signifikansi dengan nilai 0,000 dan nilai koefisien regresi sebesar 0,401. Hal ini menunjukkan bahwa hipotesis kedua diterima.
Revolutionary Flipbook-Based Digital Comic: Changing Student Engagement in Learning
Authors: Elfina Eni , Waskito Waskito , Darni Resmi , Maksum Hasan , Novaliendry Dony
Published: June 2024

The development of digital technology has had a significant impact on various aspects of life, including education. The use of digital media in learning is a necessity to motivate and increase students' interest in learning. One form of digital media that attracts attention is flipbook-based comics. This research aims to develop digital flipbook-based comics as an innovative learning tool to increase students' interest in learning. This research uses a 4D development approach (Define, Design, Develop, and Disseminate) to design, develop, and implement digital flipbook-based comics as an innovative tool aimed at increasing students' interest in learning. This research also involved testing with a number of students to evaluate the effectiveness and attractiveness of digital flipbook-based comics as a learning tool. The data collected involves aspects of learning interest, understanding of the material, and student satisfaction with the use of digital flipbook-based comics. The research results show that the use of digital flipbook-based comics can significantly increase students' interest in learning. Students responded positively to the interactive and fun learning experience. Therefore, the development of digital flipbook-based comics is an innovative solution in increasing students' interest in learning in this digital era.
Pengelolaan Limbah Organik Rumah Tangga Menjadi Pupuk Organik untuk Peningkatan Fungsi Pekarangan Sebagai Penghasil Bahan Pangan Keluarga di Kecamatan Tamansari Kota Tasikmalaya
Authors: Nuryati Rina , Priyadi Rudi , Faqihuddin Faqihuddin , Permata Bunda Cici Aulia , Juhaeni Ade Hilman
Published: June 2024

The amount of waste in Tasikmalaya City that can be transported to the Ciangir Final Disposal Site is only around 61 percent. Households can play a role in supporting reducing rubbish or waste by processing it into useful items, including processing organic waste into organic fertilizer. However, making organic fertilizer must be in accordance with the recommended procedures so that it does not have a negative effect on plants, so it is necessary to carry out Community Service. Regarding the management of household organic waste into organic fertilizer to improve the function of the yard as a family food producer. Teh Community service was implemented using counseling and training methods from May to November 2023 for the Women's Farmer Group, namely Kusari and Sauyunan located in Cigintung, Sumelap Village, Tamansari District, as well as women from the Dharma Wanita Association at Siliwangi University, Tasikmalaya. From the results of the activities, it can be concluded that household waste that is managed well will provide economic, social and environmental benefits and vice versa. Well-managed organic household waste will become organic fertilizer which can be applied to plant cultivation in the yard so that the yard is more productive as a provider of family food while providing social and ecological benefits.
 
Abstrak
Sampah di Kota Tasikmalaya yang dapat diangkut ke Tempat Pembuangan Akhir (TPA) Ciangir baru sekitar 61 persen. Rumah tangga dapat berperan dalam mendukung mengurangi sampah atau limbah dengan mengolahnya menjadi barang yang bermanfaat diantaranya mengolah limbah organik menjadi pupuk organik.. Namun pembuatan pupuk organik harus sesuai dengan prosedur yang disarankan agar tidak berpengaruh negatif terhadap tanaman maka perlu dilakukan Pengabdian kepada Masyarakat (PkM) tentang pengelolaan limbah organik rumah tangga menjadi pupuk organik untuk peningkatan fungsi pekarangan sebagai penghasil pangan keluarga. PkM dilaksanakan menggunakan metode penyuluhan dan pelatihan dari bulan Mei sampai November 2023 terhadap Kelompok Wanita Tani (KWT) yaitu KWT Kusari dan Sauyunan yang berlokasi di Kampung Cigintung Kelurahan Sumelap Kecamatan Tamansari serta ibu-ibu Dharma Wanita Persatuan (DWP) Universitas Siliwangi Tasikmalaya. Dari hasil kegiatan PkM dapat disimpulkan bahwa limbah rumah tangga yang dikelola dengan baik akan memberikan manfaat ekonomis, sosial dan lingkungan serta sebaliknya. Limbah rumah tangga organik yang terkelola dengan baik akan menjadi pupuk organik yang dapat diaplikasikan pada budidaya tanaman di pekarangan sehingga pekarangan lebih produktif sebagai penyedia bahan pangan keluarga sekaligus memberikan manfaat sosial dan ekologi.
Exact Solution of Tank Drainage for Bingham Fluid flow circular tube
Authors: Ghulam Murtaza Oghai  , Memon Kamran Nazir , Syed Feroz Shah  , Azam Ali Amur
Published: June 2024

Unsteady tank drainage of Bingham Plastic fluid whose flow of the fluid is due to gravity, is considered in this study. The separation of variables method is used to obtain the exact solution of the fluid. Due to very high yield stress of the fluid no slip condition is used to find out the velocity profile of the fluid. The primary objective of this work is to find the velocity profile, flow rate, shear stress, average velocity, time efflux, the relationship between the time (varying with the depth of a tank) and the time required for complete drainage from emerging partial differential equation. It has been observed that when the Bingham model parameters, flow region and pipe length increase, the time required to drain the fluid from the tank also increases. Furthermore, findings indicate that higher density and a larger pipe radius result in quicker drainage of Bingham plastic fluid from the circular tank.
A versatile optional randomized response technique for use with sensitive surveys
Authors: Azeem Muhammad , Abdul Salam
Published: June 2024

In data collection from human participants, researchers in almost every survey get refusals and/or false responses from the respondents. Such refusals and false reporting are particularly common in sample surveys where the participants are asked to answer questions on sensitive topics such as cheating in examination, illegal income, marks obtained in last examination, students’ satisfaction from the teaching method, and amount of money spent on luxury items, etc. A popular approach to deal with the problem of refusals and untruthful responses is the randomized response technique. This paper introduces a randomized response model which is more precise than the available models. The proposed randomized scrambling procedure guarantees the privacy protection of the respondents for motivating them to participate in the survey.
Series Solution of Unsteady Tank Drainage for Third Order Fluid using Adomian Decomposition Method
Authors: Shehzad Ali Malik  , Syed Feroz Shah  , Kamran Nazir Memon  , Afaque Ahmed Bhutto  , Azam Ali Amur
Published: June 2024

In this research study the tank model of isothermal and unsteady drainage is considered. Geometry of the tank is in cylindrical and at the bottom a pipe for flow of the fluid is attached. Sub class of viscoelatic non-newtonian fluid is considered. It is planed to obtain the series solution of the model with Adomian Decompositon in the light of no slip conditon. It is also decided to compare the velocity profile of adomain decompositon with the perturbation method for this fluid. On the basis of the results and comparison efficiency of both methods will be disscussed.
Investigation the Stochastic behaviour of the Traffic Flow: A Case Study of a Section of a Road
Authors: Mehboob Ali Jatoi  , Shakeel Ahmed Kamboh  , Oshaque Ali Abro  , Saeed Ahmed Rajput  , Liaquat Ali Zardari
Published: June 2024

The stochastic behavior is one of the key for the current state of vehicles flow for the real time traffic behavior. This paper describe the study to investigate the stochastic behavior of real time traffic flow for a section of road using probability distribution fit over the section of road, the traffic data was collected for a week from 7:00 to 19:00 at the location Nawabshah Pakistan. The different distribution such as Normal, Lognormal, Weibull, Gamma, Exponential distribution was fit using MATLAB distribution fit by probability plot of traffic flow data. The same distribution was used for the goodness-of-fit tests by considering Kolmogorov-Smirnov, Kolmogorov-Smirnov modified, Anderson-Darling were used with p-values at 95% of confidence level and justification to accept the hypothesis test are accepted or rejects. The hypothesis accept for Normal, Weibull and Gamma distribution which accept the all hypothesis test and among these three accepted fit distribution the Normal probability distribution fit is most fitted distribution using the rank by p-value of the hypothesis tests.
Keywords: Traffic flow, Goodness-of-fit, Probability Distributions, Nawabshah
Mathematical and computationalmodeling of migrations, population spread, and Location-dependent carrying capacities
Authors: Soomro Faraz Ahmed , Ahmed Israr , Panhwar Waheed Ali , Soomro Shah Rukh
Published: June 2024

In single-variable calculus, differential equation models for population dynamics are of high importance and by developing these ordinary differential equation (ODE) models, a practical and intelligible approach can be created to partial differential equations (PDEs). This paper researches focus on PDE models for migrations, population spread and location-dependent carrying capacities. However, logistic equation from which the PDE models develop include the diffusion equation, traveling wave equation, and building blocks with location-dependent parameters. This methodology is suitable for multivariable calculus lecture, evaluation task, and problem activity. The text is accompanied by interactive examples, and the article is formatted to be used as a CDF document in which some of the input can be hidden.
Analysis of the Nutritional Quality of Local Feed Ingredients Commonly Used in the Concentrate Formula for Beef Cattle Feedlots in Indonesia
Authors: Huda Thoriqul Irfah Al , Agus Ali , Noviandi Cuk Tri , Andarwati Siti , Astuti Andriyani
Published: June 2024

Indonesia's annual beef consumption is experiencing a steady rise. In 2021, the per capita beef consumption amounted to 2.56 kg per person per year, resulting in a total of 696 million kilograms consumed across the country. This quantity is equivalent to the slaughtering of approximately 3.98 million cattle annually. With the increasing growth of the feedlot industry, cattle farmers, including feedlot operators, have the opportunity to enhance the value of agricultural companies in Indonesia by utilizing local feedstuffs. The objective of this study was to assess the suitability and nutritional value of indigenous feed sources for beef cattle in Indonesia. The research utilized feedstuff varieties and characteristics sourced from feedlots spanning since 2012-2021. The employed methodologies encompassed surveys, interviews, and questionnaires. This research involved the collection of both primary and secondary data. The potential and quality of local feedstuff were described using descriptive analysis. This research showed that eight types of local feedstuff could be categorized as energy sources including dehydrated cassava chips with a total digestible nutrients (TDN) value of 84.2% and bran pollard with a TDN value of 66.6%. The fiber sources consisted of corn cob (37.7% crude fiber), coffee husk (38% crude fiber), cocoa bean shell (20% crude fiber), tapioca solid waste/onggok (22% crude fiber), and palm kernel meal (22.1% crude fiber). The protein source consisted of copra meal with a protein content of 22.4%. The physical test most frequently inspected the feed color (18.1%) and odor (18.1%). Moisture examination (24%) was the most frequently used of proximate analysis was employed to identify the chemical composition. In conclusion the existence of eight local ingredients which were categorized into three different types: energy source, protein source, and fiber source commonly used in the concentrate formula for beef cattle feedlots in Indonesia.
Effects of Dietary Inclusion of Angelica gigas Nakai root extract on the Growth Performance, Hematological and Serum Biochemical Parameters in Broilers
Authors: Dela Cruz Joseph Flores , Purnamasari Listya , Hwang Seong Gu
Published: June 2024

The study aimed to evaluate the impact of dietary supplementation with Angelica gigas Nakai (AGN) root extract on growth performance, hematological indices, and serum biochemical parameters in broiler chickens. A total of 320 straight-run Cobb broiler chicks from a commercial hatchery were distributed among four treatment groups: Basal diet (BD) as the Control; Treatment 1 (T1): BD + 2 g/kg AGN; Treatment 2 (T2): BD + 4 g/kg AGN; and Treatment 3 (T3): BD + 8 g/kg AGN), each comprising eight replicates with 10 birds per replicate. The supplementation of AGN resulted in dose-dependent improvements (P < 0.05) in body weight, gain, and feed efficiency. On both day 21 and day 35, increasing AGN dosage in the diet led to a significantly higher (P < 0.05) values of red blood cells (RBCs), white blood cells (WBCs), hemoglobin (Hb), and packed cell volume (PCV). By day 21, AGN supplementation dose-dependently decreased (P < 0.05) serum alkaline phosphatase (ALP), aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), urea, and creatinine levels. Meanwhile, AGN dose escalation correlated with a notable increase (P < 0.05) in serum total protein (TP), albumin, and globulin levels. On day 35, increasing AGN levels led to a significant reduction (P < 0.05) in serum AST and ALT activity, along with lowered serum glucose, cholesterol, triglycerides, urea, and creatinine levels. In conclusion, AGN supplementation enhanced growth performance and positively influenced hematological indices and serum biochemistry profiles in broiler chickens. The study confirms the safe and effective utilization of AGN at an 8 g/kg (0.8 %) feed additive dosage to optimize broiler performance. These findings provide valuable insights into the potential benefits of AGN in poultry nutrition.
Influence of Retanning Agents on Physical Characteristics of Snow-White Glove Leather from Goat Skin
Authors: Yuliatmo Ragil , Maryati Tutik , Rahmawati Atiqa , Adamu Dahiru J M , Mizan Al
Published: June 2024

The quality of leather is subject to various elements, such as the specific raw material used, and the processing techniques implemented throughout the production process. Goatskin, renowned for its exceptional softness and durability, is frequently employed in the production of gloves owing to its desired attributes, notably its capacity to produce snow-white gloves. Retanning is an essential step in the leather manufacturing process as it significantly improves the characteristics of the leather. Through an investigation into the impacts of distinct retanning agents on goatskin leather gloves, this research endeavor seeks to offer significant knowledge regarding the most effective retanning procedures that can augment the tactile attributes of snow- white leather gloves. In this study, formaldehyde, alum, chromium, and chromium alum were employed as retanning agents. The retanned leathers were assessed by physical parameters, Principal Component Analysis (PCA), and Fourier Transform Infrared spectroscopy (FTIR), then compared to a commercially available snow-white leather glove. The physical characteristics of chrome alum retanned leather showed a high degree of softness (6.60±0.02 mm), good tear strength (1.530±117 N/cm), and tensile strength (1.500±100 N/cm 2 ). The principal component analysis (PCA) also supported that the properties of chrome alum retanned snow-white glove leather closely resemble commercial leather and the result from this study suggested that all factors notably impact the skin's physical quality, except for thickness. Additionally, the FTIR analysis reveals similar functional groups from the different retanned leathers indicated by comparable peaks and stretching patterns. Therefore, chrome-alum could be a well alternative retanning agent for the production of snow-white glove leather.
Maximizing Employee Performance through Compensation, Engagement, and Commitment
Authors: Rachman Wahyu Fathur , Sumartik Sumartik
Published: June 2024

This quantitative study investigates the combined impact of compensation, employee engagement, and organizational commitment on employee performance at PT. BPR Arta Seruni, Sidoarjo Branch. Utilizing multiple linear regression analysis and a sample of 80 employees, the study reveals that all three factors—compensation, employee engagement, and organizational commitment—positively influence employee performance individually, and collectively have a significant effect. The findings underscore the importance of addressing these factors collectively to enhance employee performance within the banking industry, offering insights for organizational strategies aimed at improving effectiveness and satisfaction among employees, thus contributing to sustainable growth and success.
Highlights:
1. Study: Compensation, engagement, commitment impact employee performance in banking.2. Positive effects found individually and collectively.3. Collective focus crucial for employee satisfaction and organizational effectiveness.
Keywords: Compensation, Employee Engagement, Organizational Commitment, Employee Performance, Banking Industry
Upaya Mengatasi Bullying melalui Edukasi Pendidikan Karakter
Authors: Anggraini Ratna Dwi , Nopriansyah Untung , Setiawan Rendi , Adelia Anggita , Arinda Devi , Maharani Putri
Published: June 2024

Bullying is a form of child abuse that is perpetrated by peers against someone (child) who is "lower" or weaker in order to gain certain benefits or satisfaction. The culture of bullying (violence) in the name of seniority still continues among students in elementary schools, bullying usually occurs repeatedly, some are even carried out in a planned manner. The method used in this research is qualitative. Results of the activity In the implementation of community service The location of community service was carried out at SDN 7 Tanjung Raya, on August 5 2023. The duration of this activity was carried out for 4 hours, namely at 08.00 - 11.00 WIB. what has been explained in this socialization, after carrying out this socialization the author hopes that students can have good insight to be able to respond to association in this millennial era which is in accordance with the view of the Islamic religion. This socialization also describes the negative impact of bullying and helps students to be able to fortify themselves from bullying behavior and from the ease of obtaining negative information. This is of course something that must be done by educational institutions and parents to contribute in looking after students so that they can become children with good character who can later be useful for the community/country.
WITHDRAWN: Novel hydro-alcoholic sanitizer model with minimum alcohol content and fortified with eugenol and cinnamaldehyde as natural antimicrobial boosters
Authors: Shaaban Hamdy A. , Abdelhamid Samy M. , Edris Amr
Published: June 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Intratumoral Fc-optimized agonistic CD40 antibody induces tumor rejection and systemic antitumor immunity in patients with metastatic cancer
Authors: Osorio Juan , Knorr David , Weitzenfeld Polina , Yao Ning , Baez Maria , DiLillo Meghan , Rahman Jahan , Bromberg Jacqueline , Postow Michael , Ariyan Charlotte , Robson Mark , Ravetch Jeffrey
Published: June 2024

While CD40 agonism is an attractive approach for activating antigen-presenting cells and initiating antitumor responses, previous attempts have encountered limited clinical efficacy coupled with toxicity. We previously demonstrated that interactions between the antibody Fc domain and the inhibitory receptor FcγRIIB are critical for enhanced antitumor activity. Here, we present the results of a phase 1 study on intratumoral administration of an anti-CD40 agonistic antibody (2141-V11) Fc-engineered to enhance FcγRIIB binding. Primary endpoints included safety, maximum tolerated dose (MTD), and recommended phase 2 dose. Secondary objectives included preliminary clinical activity and correlative studies from biospecimens. 2141-V11 was well-tolerated without dose-limiting toxicities and MTD was not reached. In ten evaluable patients with metastatic cancer, the overall response rate was 20%, with complete responses in two patients (melanoma and breast carcinoma) and stable disease in six patients. 2141-V11 induced tumor regression in injected and non-injected lesions, with increased leukocyte infiltration and tertiary lymphoid structures (TLS) formation in post-treatment biopsies. In a humanized mouse model for CD40 and FcγRs, 2141-V11 induced TLS formation in mice bearing orthotopic breast carcinoma, correlating with local and abscopal antitumor effects, systemic immune activation, and immune memory. These findings support the safety and efficacy of 2141-V11, warranting phase 2 studies and suggesting a unique mechanism of action for this Fc-enhanced immunotherapy (NCT04059588).
An Information-Centric Approach to Enhance Network Lifetime in Water Quality Monitoring WSNs
Authors: Abdolabadi Hamid
Published: June 2024

In water quality monitoring networks, efficient sensor operation and network lifetime are crucial for timely and accurate data collection. Existing models often focus on minimizing overall network energy consumption and typically treat all sensors equally, making no distinction based on the information value of the data collected. This may lead to the unnecessary transmission of redundant data from low-value sensors. This research proposes a novel information-centric algorithm specifically designed for Wireless Sensor Networks (WSNs) deployed in such applications. The algorithm leverages information theory and Minimum Redundancy, Maximum Information (MIRI) principles to identify and prioritize data from sensors with high information value. The new algorithm integrates an energy-efficient consumption model with a strategic Cluster Heads selection approach. This approach prioritizes keeping sensors with high information content alive within clusters, further minimizing total energy consumption. By strategically selecting sensors and reducing redundant data collection, the proposed algorithm achieves a higher average residual energy compared to the existing model. This indicates more efficient energy utilization and potentially longer individual sensor lifetimes. These results demonstrate the effectiveness of the information value-centric approach in optimizing WSN performance. The algorithm extends network lifetime and paves the way for further exploration of information-centric techniques for enhancing WSN efficiency and longevity.
Multi-task Multi-modal Graph Neural Network for Recommender System
Authors: Jiao Shengzhe , Zhang Yihong , Hara Takahiro
Published: June 2024

With the explosive growth of online information, users may also face information overload. To handle this problem, recommender systems have become an effective strategy, which can analyze the characters of users and items to provide valuable information. One of the important types of information is the item’s side information. For example, in Amazon dataset, side information mainly includes visual side information (e.g., image and video), textual side information (e.g., title and description), and auxiliary side information (e.g., brand and category). To analyze various types of side information, some research designed multiple modalities for different types of side information, which can improve the performance of the recommender system. To analyze the deeper relationships between users and items, recent works also use a graph structure to represent the interactions. Existing works on multi-modal recommender systems using graph neural networks largely depend on the interaction records, while little effort focuses on the relationships between interactions and various types of side information. In this paper, we propose a novel multi-task learning model. First, we construct the interaction records to graphs for each modality to gather the representations, and then we analyze the representations of each modality and the specific side information based on the similarities. We design a Multi-task Multi-modal Graph Neural Network (MTMM-GNN) framework built upon message-passing with the attention mechanism of graph neural networks, which can generate the representations of users and items from interaction records, and then analyze the relationships between the representations from GNNs and item’s side information. We conduct experiments on two public datasets, Amazon and MovieLens, and the results of our model outperform the state-of-the-art methods.
Impact of ISPD Guidelines and the COVID-19 Pandemic on Peritoneal Dialysis Peritonitis Rates: A Retrospective Cohort Study
Authors: Aarabi Amirhossein , Karthik Kumar
Published: June 2024

This retrospective cohort study investigates the impact of prophylactic measures on Peritoneal Dialysis (PD) related peritonitis, with a particular focus on contrasting periods before and after the onset of the COVID-19 pandemic.1 The research entailed an analysis of patient data over several years, centred on the implementation of the International Society for Peritoneal Dialysis (ISPD) guidelines.2 Methodologically, the study contrasts PD peritonitis rates, types of causative organisms, peritonitis-related hospitalization frequencies, and mortality rates before and after the reinforcement of ISPD guidelines. The results revealed a notable decrease in the overall incidence of PD peritonitis post-implementation of these guidelines. However, the COVID-19 pandemic period showed a temporary reversal of this trend, with an increase in peritonitis rates, likely due to disrupted healthcare services and altered patient behaviours during the pandemic.3 Furthermore, our analysis highlighted a shift in the microbiological profile of peritonitis-causing organisms in the post-pandemic period. The study's findings illuminate the dynamic nature of PD peritonitis management in response to major healthcare interventions and global health crises. The decreased peritonitis rates post-ISPD guidelines underscore their effectiveness, while the pandemic's impact reveals vulnerabilities in healthcare delivery during crises. These insights are pivotal for shaping future PD management strategies and enhancing patient care in both standard and challenging healthcare environments.
SRFE: A Stepwise Recursive Feature EliminationApproach for Network Intrusion Detection Systems
Authors: Qasem Abdelaziz Alshaikh , Qutqut Mahmoud H. , Alhaj Fatima , Kitana Asem
Published: June 2024

Network intrusion detection systems (NIDS) have evolved into a significant subject in cybersecurity research mainly due to the growth of cyberattacks and intelligence, which also led to using machine learning (ML) to advance and enhance NIDSs. A NIDS is the first line of defense in any environment, and it detects external and internal attacks. Recently, intrusion mechanisms have become more sophisticated and challenging to detect. Researchers have applied techniques such as ML to detect intruders and secure networks. This paper proposes a novel approach called SRFE (stepwise recursive feature elimination) to improve the performance and efficiency of predictive models for NIDSs. Our approach depends primarily on recursive feature elimination, which operates on a simple yet effective principle. We experimented with four classification algorithms, namely Support Vector Machine (SVM), Naive Bayes (NB), J48, and Random Forest (RF), on the most widely used dataset in the cybersecurity domain (NSL-KDD). The approach is mainly built on the features' significance ranking using the Information Gain (IG) method. We conduct multiple experiments according to three scenarios. Each scenario contains various rounds, and in each round, we train the classifiers to eliminate the three lowest-ranked features stepwise. Our experiments show that the RF and J48 classifiers outperform other binary classifiers with an accuracy of 99.80% and 99.66%, respectively. Furthermore, both classifiers obtained the best results in the multiclass classification task; J48 achieved an accuracy of 99.53% in round number seven, and the RF achieved 99.69% in the fifth round.
Tuning of the Band Gap and Suppression of Metallic phase by Ca doping in La1-xCaxMnO3 Manganite Nano-particles
Authors: Ali Liaqat , Shah Wiqar Hussain , Khan Shayan , Ali Akhtar , Hessien Mahmoud M. , El-Bahy Zeinhom M.
Published: June 2024

Polycrystalline compounds of lanthanum calcium manganite La1-xCaxMnO3, (LCMO) are extensively utilized in energy conversion systems because of their low losses and features related to the transfer of electric charges. This work aimed to examine the impact of different levels of Ca 2+ replacements (x = 0.1, 0.2, and 0.3) on the adjustment of the optical band gap and dielectric losses in La1-xCaxMnO3 nanoparticles. The synthesized samples underwent structural analysis using X-ray diffraction. All generated samples were proven to have an orthorhombic R 3 ̅ c crystal structure. The estimated crystallite size ranged from 25 nm to 32 nm, and other lattice characteristics were also determined. An agglomerated spherical form consisting of nanoparticles with a range of (33-46 nm) can be seen in the scanning electron micrographs of all of the LCMO samples. The nanoparticles had a moderate size distribution and were influenced by narrower grain boundaries. Energy-dispersive X-ray spectroscopy was utilized to verify the elemental makeup of each chemical, while the infrared spectrum revealed bonding in the fingerprint region. A considerable decrease in the optical band gap was detected through the analysis of UV spectrometer absorption data. The band gap exhibited a reduction from 3.95 eV to 3.74 eV. The decrease was determined to be associated with the disparity in refractive index, which was computed using both Moss and Herve-Vandamme equations. Simultaneously, frequency-dependent dielectric study indicated a direct correlation between frequency and the rise in Ca concentration, resulting in an inverse impact on dielectric loss. In addition, the electrical conductivity of these nano-system that were created design as the Ca content grew. This increase was represented by Johnscher's universal power law in the high frequency range.
Tool wear state prediction based on GAF-MTF-AlexNet
Authors: Yu Haiyue , Yang Ruiqi , Liu Haonan , Du Wei , Zhang Junqiu , Han Zhiwu
Published: June 2024

The manufacturing sector commonly employs traditional systems for predicting tool wear states, which rely on one-dimensional numerical inputs, in order to mitigate the issues of escalating costs and reduced efficiency that stem from excessive tool wear. However, these models face drawbacks such as high computational demands and limited generalization capabilities. To overcome these challenges, this study introduces a novel method for predicting tool wear states, which leverages the Gramian Angular Field-Markov Transition Field-AlexNet (GAF-MTF-AlexNet) architecture. Initially, the vibration signal's envelope spectrum is mapped into a two-dimensional image through the application of the GAF and the MTF transformations. Subsequently, the generated image is horizontally stitched to form a comprehensive dataset. The dataset is then fed into the customised AlexNet model for the purpose of prediction. Following meticulous research and optimisation, this method enhances signal visualisation and allows deep learning algorithms to extract signal features more effectively, resulting in a significant improvement in accuracy to 96.83%. This precision far surpasses that of conventional one-dimensional data input approaches, thus validating the efficacy of the measures implemented. The empirical results demonstrate that the method is proficient in predicting the transition of tools across diverse wear states. Consequently, this approach provides a robust technical foundation for the manufacturing industry to reduce production costs, improve operational efficiency, and facilitate predictive maintenance practices.
Neutrons reveal the dynamics of leaf thylakoids in living plants
Authors: Stingaciu Laura-Roxana , O’Neill Hugh , Liu Chung-Hao , Evans Barbara R. , Nagy Gergely
Published: June 2024

The study is the first known exploration of photosynthetic membranes dynamics in living plants by high resolution inelastic neutron scattering spectroscopy. We characterized in vivo thylakoid membranes mobility in Lemna minor plants. Excess dynamics at length scales corresponding to both the membrane stacks and membrane thickness were observed and described by classical biophysical models to assess the undulation modes, the rigidity of the membranes, and how the structural variations affect the observed dynamics. The stacks of thylakoids in Lemna minor are rigid systems with an apparent bending coefficient in the upper range observed for surfactant membranes, while the single thylakoid leaflet is very flexible situated well within the bi-continuous surfactant phases dynamics. These observations further our understanding of the relationship between photosynthesis and the cellular architecture, while simultaneously opening more questions and the need for further investigations at extended q-and-time regimes.
Morphological and genetic screens reveal mechanisms of BiDAC-induced plasma membrane protein degradation
Authors: Bersuker Kirill , Jafri Qumber , Lazzari-Dean Julia , Sangha Manjot , Villa Sammy , Lefebvre Austin , Fitzgerald Mark , Jackson Katrina , Chen Zhenghao , Feng Brian , Nile Aaron , Stokoe David
Published: June 2024

The discovery of bifunctional degradation activating compounds (BiDACs) has led to the development of a new class of drugs that promote the clearance of their protein targets. BiDAC-induced ubiquitination is generally believed to direct cytosolic and nuclear proteins to proteolytic destruction by proteasomes. However, pathways that govern the degradation of other classes of BiDAC targets, such as integral membrane and intraorganellar proteins, have not been investigated in depth. In this study we used morphological profiling and CRISPR/Cas9 genetic screens to investigate the mechanisms by which BiDACs induce the degradation of plasma membrane receptor tyrosine kinases (RTKs) EGFR and Her2. We found that BiDAC-dependent ubiquitination triggers the trafficking of RTKs from the plasma membrane to lysosomes for degradation. Surprisingly, functional proteasomes were required for endocytosis of RTKs upstream of the lysosome. Additionally, our screen uncovered a non-canonical function of the lysosome-associated arginine/lysine transporter PQLC2 in EGFR degradation. Our data show that BiDACs may target proteins to proteolytic machinery other than the proteasome and motivate further investigation of mechanisms that govern the degradation of diverse classes of BiDAC targets.
Co-delivery of Tacrolimus and Thymoquinone topically by Nanostructured lipid carriers gel for enhanced efficacy against imiquimod-induced psoriasis in Balb/c mice
Authors: Alam Meraj , Rizwanullah Md. , Ahmad Shahnawaz , Iqubal Ashif , Mir Showkat R. , Kim Tae-Geum , Amin Saima
Published: June 2024

The primary objective of this current investigation is to evaluate the antipsoriatic potential of a novel nanogel delivery system that co-encapsulates tacrolimus and thymoquinone within nanostructured lipid carriers (NLCs). Therefore, TAC-THQ-NLCs-gel was formulated by emulsification solvent-evaporation technique and evaluated for their potential in improving skin permeation, skin bioavailability, skin safety, and therapeutic efficacy in imiquimod-induced psoriasis in mice plaque model. The ex-vivo skin permeation study shows 2.51- and 2.12-folds higher permeation for TAC-THQ-NLCs-gel as compared to TAC-THQ-suspension-gel, also the permeation enhancement mechanism of NLCs gel was confirmed using FTIR and DSC. Further skin retention study shows 2.87- and 2.36-fold improvement in retention of the drug as compared to free drug gel formulation. Further, the dermatokinetic study shows 2.78 and 2.37 folds higher Cmax and 2.93- and 2.40-fold higher AUC (area under the curve) for TAC and THQ respectively as compared to free drugs gel. The results of the in-vivo skin compliance study suggested that the fabricated TAC-THQ-NLCs-gel was safe for skin delivery. Furthermore, TAC-THQ-NLCS-gel represented much better amelioration of psoriasis in Balb/c mice, with a cumulative PASI score reduction of 83.80% as compared to 57.14% for free drugs gel after the end of treatment. In addition, the insignificant changes in the histology of the skin, spleen, and liver further confirm the efficacy and safety of the developed TAC-THQ-NLCs-gel. Based on these observations, it can be inferred that TAC-THQ-NLCs-gel holds promise as a combined treatment approach for managing psoriasis topically.
Body Image: a Cross-sectional Study of the Perception and Practices of Women After Delivery
Authors: Owusu Lydia Boampong , Issifu Joseph Shahadu , Efah Abrah Nana Yaa , Yeboah Dorcas , Agyemang Suzzie Ntiriwaa , Owiredu Emmanuel Odame , Suglo Zakaria Abdul-Fatawu , Dwumfour Catherine Kroamah , Emikpe Abigael , Addai-Henne Sandra
Published: June 2024

Background
Women's bodies undergo major changes during pregnancy and childbirth that are typically interpreted negatively, resulting in body dissatisfaction or a negative body image. Postpartum women have diverse perceptions of their bodies, which are influenced by the strategies they employ to address social norms related to female attractiveness. This study therefore sought to examine the perception of and satisfaction with body image after delivery and practices to achieve ideal body image among postpartum women.
Methods
This study employed a cross-sectional descriptive design. Data from 361 postpartum women who visited the Child Welfare Clinic at three hospitals were gathered using a semi structured questionnaire. The study used a quantitative technique and a descriptive research design to accomplish this goal. A researcher-created questionnaire was utilized to collect data from 361 postpartum women who were chosen for the study using a convenience sampling technique. SPSS version 27 was used to analyze the data. Both descriptive and inferential statistics were employed, with a P value of 0.05 indicating statistical significance.
Results
The majority (56.23%) were happy with their bodies after delivery, while 32.13% asserted that their partners were not happy with their bodies after delivery. Wearing belly bands (28.53%), consuming weight loss tea (11.36%), and eating less (9.14%) with few women exercising (1.94%) were practices women engaged in to obtain their ideal body after delivery. The factors influencing body image satisfaction among postpartum women include marital status and educational level (p ≤ 0.05).
Conclusion
Most postpartum women expressed satisfaction with their bodies after delivery, and it is essential to acknowledge the minority who do not share this sentiment. This study sheds light on the diverse practices employed by women to achieve their ideal body image, ranging from conventional methods such as exercise to more unconventional approaches such as wearing belly bands or consuming weight loss tea. Moreover, factors such as marital status and educational level were found to influence body image satisfaction among postpartum women.