bluuebunny/crossref_metadata_2025 huggingface dataset:
Bantuan sosial dan pendidikan kesehatan bagi masyarakat pesisir yang terdampak sosial-ekonomi selama patogenesis Covid-19 di Manggarai
Authors: Tapung Marianus Mantovanny , Regus Max , Payong Marsel Ruben , Rahmat Stefanus Turibus , Jelahu Frederikus Maigahoaku
Published: July 2020

[Bahasa]: Pandemik Covid-19 telah berdampak pada masyarakat pesisir di wilayah utara dan selatan Manggarai. Mereka mengalami keterpurukan sosial ekonomi selama patogenesis Covid-19. Daya tawar hasil panen di laut dan di ladang mengalami penurunan drastis. Situasi ini membuat masyarakat pesisir mengalami kesulitan dalam menjalani hidup. Persoalan ini menarik untuk dikaji dan menjadi dasar dalam melakukan pengabdian masyarakat dalam bentuk bantuan sosial dan pendidikan kesehatan. Kegiatan pengabdian ini bertujuan untuk memberi bantuan sosial dan pendidikan kesehatan kepada masyarakat pesisir Kegiatan bantuan sosial dan pendidikan kesehatan dilakukan agar masyarakat pesisir bisa terbantu secara sosial ekonomi pada masa pandemi dan kesadaran kritisnya tumbuh terkait bahaya Covid-19. Kegiatan ini juga bertujuan menumbuhkan kesadaran masyarakat akan pentingnya perilaku hidup sehat dan bersih. Dengan menambah asupan makanan yang cukup, tubuh mereka memiliki imunitas yang baik sehingga bisa bertahan dari serangan virus. Kegiatan pengabdian kepada masyarakat pesisir ini dilakukan dengan mengadaptasi dan memodifikasi pendekatan IPOAI (Identifying, Planning, Organizing, Acting, Impact). Hasil kegiatan menunjukkan adanya peningkatan kesadaran masyarakat pesisir akan pentingnya memelihara kesehatan. Bantuan sosial yang diberikan juga membantu meningkatkan asupan gizi sehingga menjaga imunitas tubuh di masa pandemik Covid-19.

Kata Kunci: bantuan sosial, pendidikan kesehatan, dampak sosial ekonomi, Covid-19

[English]: The Covid-19 pandemic has impacted coastal communities in the northern and southern regions of Manggarai. They experienced a socio-economic downturn during the pathogenesis of Covid-19. The bargaining power of harvest in the sea and the fields has decreased dramatically. This situation makes it difficult for coastal communities to live their daily life. This issue is interesting to study and become the basis for this community service program which aims to provide social assistance and health education to coastal communities. The programs were carried out to support economic condition of coastal communities in the pandemic, educate the danger of Covid-19, and raise public awareness of the importance of healthy and clean-living behaviors. For example, adequate food intake will help their bodies have good immunity to survive the virus. This community service program refers the adaptation and modification of the IPOAI approach (Identifying, Planning, Organizing, Acting, Impact). The results show the increase in awareness of coastal communities of the importance of maintaining health. The social assistance also helps to increase nutritional intake and thus helps maintain body immunity during the Covid-19 pandemic.

Keywords: social assistance, health education, social economic impact, Covid-19
Propiedades psicométricas del Patient Health Questionnaire (PHQ-9) en estudiantes de medicina en Lima, Perú.
Authors: Huarcaya-Victoria Jeff , De-Lama-Morán Raúl , Quiros María , Bazán Jimena , López Kevin , Lora Dáneri
Published: July 2020

Se ha reportado que el Patient Health Questionnaire (PHQ-9) es una herramienta psicométricamente válida y confiable aun cuando, evaluado mediante análisis factoriales, no queda claro si una estructura de uno o dos factores es la mejor. Objetivo: Evaluar las propiedades psicométricas y la estructura factorial del PHQ-9 en estudiantes de medicina de una universidad del Perú. Material y Métodos: Investigación instrumental en 200 estudiantes de medicina. Un análisis factorial exploratorio (AFE) permitió evaluar la estructura interna del PHQ-9, sometida luego a un análisis factorial confirmatorio (AFC) de tres modelos. Resultados: Se encontró una adecuada consistencia interna (alfa de Cronbach=0,903). Mediante el AFC se encontraron adecuados índices de ajuste en el modelo bifactorial (x2 (17) = 26,451, p = 0,067; CFI = 0,991; GFI = 0,969; RMSEA = 0,056) en comparación con los modelos unidimensional y bidimensional. Conclusiones: El PHQ-9 es un instrumento con propiedades psicométricas adecuadas para su aplicación en estudiantes de medicina de una universidad del Perú. El AFC reveló que un modelo bifactorial que toma en cuenta tanto el factor general como factores latentes somáticos y cognitivo/afectivos, muestra un mejor ajuste.
How can the water regime and nitrogen status of the vine influence aging aromas in red wines?
Authors: Le Menn Nicolas , Van Leeuwen Cornelis , Riquier Laurent , De Revel Gilles , Marchand Stéphanie
Published: July 2020

This study looked for a possible link between the water and nitrogen regimes measured in the vineyard and the aromatic compounds responsible for the aging bouquet of red wines. The wines studied for this purpose were produced in the Bordeaux region and aged for between 10 and 20 years. The levels of aromatic compounds such as tabanones and dimethyl sulfide (DMS) were found to be influenced by the supply of water and nitrogen to the vine. The residual nitrogen composition of the wines was also consistent with the nitrogen status of the vines and suggests potential for aromatic precursors and microbiological instability.
Inteligencia emocional rasgo y habilidad como factores asociados al consumo de cannabis en la adolescencia
Authors: González Yubero Sara , Palomera Martín Raquel , Lázaro-Visa Susana
Published: July 2020

Diversos organismos internacionales alertan sobre el incremento de consumo de cannabis y de su uso extendido entre los adolescentes. El presente estudio ha sido uno de los primeros con el objetivo de analizar el papel de la inteligencia emocional rasgo y habilidad, basada en el modelo de Mayer y Salovey, en relación al consumo de cannabis en adolescentes. En este estudio participaron 799 jóvenes españoles con edades comprendidas entre los 12 y los 16 años. Se administró un autoinforme de inteligencia emocional (IE) rasgo, un test de rendimiento máximo de IE y se preguntó sobre los hábitos relacionados con el consumo de cannabis. Este estudio de tipo transversal se llevó a cabo a través de una metodología de corte cuantitativo y de tipo correlacional. Los principales resultados obtenidos mediante los análisis de regresión una vez controlados el género, la edad y el contexto de centro, revelaron asociaciones negativas entre los factores de comprensión y reparación emocional de la IE rasgo y las variables de consumo de cannabis, al contrario que la atención emocional. Por otro lado, en relación con la IE habilidad, los factores de percepción y facilitación se asociaron de manera inversa al consumo de cannabis en los adolescentes. Los resultados de este estudio sugieren que tanto la IE rasgo como la IE habilidad son constructos complementarios que ayudan a explicar el consumo de cannabis. Estos hallazgos proporcionan evidencias empíricas que podrían orientar intervenciones clínicas y educativas enfocadas a la prevención del consumo en esta etapa.
An estimation of the social cost of illicit drug consumption in Catalonia
Authors: Vella Vincenzo , Ibáñez Nuria , Segura Lidia , Colom Joan , García-Altés Anna
Published: July 2020

Worldwide, as well as in Spain, the use of illegal drugs is among the major contributors to the global burden of disease. Quantifying the costs that illegal drugs impose on society is key in terms of decision-making. The objective of this paper is to estimate the social cost of illicit drug consumption in Catalonia for a specific year, and to establish a methodology to be able to replicate such estimations regularly and monitor properly the impact of national plans. To do that, a cost of illness study was performed. For the estimation of mortality and morbidity costs, we relied on the Attributable Fraction approach. Only public sector costs were included: healthcare and non-healthcare costs. The cost of illegal drug consumption in Catalonia in 2011 was estimated at €326.39 million (0.16% of the Catalan GDP in 2011; 0.15% in 2018). Of the total cost, 82% corresponded to direct costs. Among direct costs, 30.32% corresponded to the penal system, 15.99% to hospitalizations, 13.48% to the police force, 17.19% to pharmacy, 8.34% to treatment in specialized centres, and 5.74% to therapeutic communities, among others. Indirect costs represented 18% of total costs, mostly lost income due to drug-related death. This study has been an opportunity to systematically collect data and think about the potential economic returns that could be achieved from effective policies and programs aimed at reducing the consumption of illegal drugs.
EFFECT OF MICROPLASTIC ON GREEN MUSSEL Perna viridis: EXPERIMENTAL APPROACH
Authors: Rahim Nur Fadhilah , Yaqin Khusnul , Rukminasari Nita
Published: July 2020

Plastics become debris in the ocean that can be broken down into tiny particles of micro size (<5 mm) and scattered into columns to the bottom of the water. Its very small size makes it easily accessible to various aquatic organisms, such as plankton, crustacean, and mussel. There have been many studies use mussel as a bioindicator for microplastic pollution but no one has observed the effect of microplastic exposure to mussel mortality. The aim of study was to examine the effect of microplastic on mussel mortality. Green mussels were collected from Mandalle Waters, Pangkep Regency (Pangkajene Kepualauan) then were exposed to microplastic polyethylene originating from shieving of scrub soap. The exposure was carried out for 7 days with microplastic concentrations of 0.05 (A), 0.5 (B), and 5 (C) g/L. Statistical test results showed the treatment B and C were not significantly different, but the two treatment were significantly different from treatment A. The percentage of green mussel mortality during the experiment increased with increasing microplastic concentrations with the percentage of mortality exceeding 80% at treatment C.
Jihad Digital: Pembingkaian Narasi Kontra Radikalisasi NU Online di Dunia Maya
Authors: Sefriyono Sefriyono
Published: July 2020

The development of digitalization has shifted the institutionalization values patterns from conventional to cyberspace, it is containing radical values through the website which also developed along with the development of digitalization. Radicalization in cyberspace requires the counter-sites which committed to religious moderation. NU Online is one of this counter-site. This study uses qualitative methods with data analysis framing techniques. NU Online distinguishes the radicalization and intolerance narratives in cyberspace is a source of the uproar of the national ideology and disharmony in the interfaith relations. In its prognosis strategy, NU Online develops the narratives such as Islam is very compatible with Pancasila. While in its motivational strategy, NU Online invites all elements of the nation to maintain the integration of the nation by publishing the headline such as “four reasons for rejecting the Khilafah”. This counter-radicalization framing is different from that carried out by panjimas.com as a representation of the radical site
HADIS DARI KLASIK LITERAL KE PORTABLE DIGITAL: Telaah Aplikasi Smartphone Mausu’ah al-Hadis al-Syarif Islamweb
Authors: Fauzi Irfan
Published: July 2020

Software mausuah Islamweb merupakan software yang hadir ditengah-tengah lajunya teknologi. Sekarang ia sudah dapat dioperasikan pada perangkat sistem komputer atau mobile. Berangkat dari sinilah kajian software tersebut akan dibahas, guna untuk menguji sejauhmana peran software hadis tersebut dalam menghadapi era digitalisasi. Seberapa urgennya software hadis ini bila bersaing dengan software-software lain yang lebih populer, seperti software Jawami’ al Kalim, Lidwa Pustaka, Maktabah Syamilah. Apakah software ini mampu memberikan kontribusi terhadap kajian hadis dalam dunia pendidikan. Serta bagaimana efektivitas software hadis ini dioperasikan oleh mahasiswa hadis UIN Sunan Kali Jaga. Tulisan ini akan berusaha mengupas permasalahan-permasalahan tersebut dengan pendekatan deskriptif-analisis. Setelah penelusuran ternyata ditemukan data bahwa software hadis ini masih dioperasikan oleh sebagian kecil dari Mahasiswa hadis. Secara defacto pun software hadis ini masih minim digunakan dalam kajian-kajian hadis tertentu. Namun adanya penelitian ini semoga kedepannya menjadi suatu ajang introduksi kepada para pelajar sekaligus dapat dioperasikan secara maksimal oleh para pelajar yang berkecimpung dalam studi hadis.
Overview of the Epizootiological Situation on Highly Pathogenic Avian Influenza Virus in Russia in 2019
Authors: Marchenko V. Yu. , Goncharova N. I. , Tran Thi Nhai , Trinh Khac Sau , Nguyen Ngoc Quyen , Gavrilova E. V. , Maksyutov R. A. , Ryzhikov A. B.
Published: July 2020

This review describes the current situation on highly pathogenic avian influenza virus in 2019 and predicts the possible further spread of avian influenza in Russia. In 2019 outbreaks were reported among wild birds and poultry, as well as human infections with influenza viruses of the subtypes H5Nx, H7N9 and H9N2 in several countries. In 2019, only two outbreaks of highly pathogenic avian influenza H5N8 in Russia occurred. Both outbreaks were recorded in January at poultry farm in the Rostov Region. In addition, in May 2019 avian influenza virus of H14N7 subtype was isolated from a wild bird during the avian influenza virus surveillance in Tomsk Region. In June 2019, a strain of H13N2 subtype was isolated in the territory of Kamchatka Region, then, in August 2019, an influenza virus of H13N6 subtype was isolated in the Saratov Region. It was revealed that some strains of avian influenza virus isolated in Russia have a high degree of identity with strains circulating in South-East Asia. This was shown by the phylogenetic analysis of A/ H5Nx influenza viruses previously isolated in the Saratov Region and the Socialist Republic of Vietnam during the avian influenza virus surveillance. Thus, it was demonstrated again that the territory of Russia plays a key geographical role in the global spread of avian influenza virus.
EVALUASI KETAHANAN AKSESI KENAF (Hibiscus cannabinus L.) TERHADAP PENYAKIT LAYU Fusarium oxysporum SCHLECT
Authors: DALMADIYO GEMBONG , SUHARA CECE , SUPRIYONO SUPRIYONO , SUDJINDRO SUDJINDRO
Published: July 2020

Evaluation on the resistance of kenaf accessions (Hibis¬ cus cannabinus /..) to Fusarium oxysporum Schlect

Resistant variety is one of the most important components controlling of fusarium wilt disease on kenaf caused by Fusarium oxysporum Schlect. To ind out resistant variety an evaluation on kenaf accessions was conducted in the laboratory and screen house of Phytopathology, RITFC, Malang in June-December 1997. The results of the selection on 77 accessions showed that 41 accessions were highly resistant, 1 2 accessions were resistant, 7 accessions were moderate, 12 accessions were susceptible, and 5 accessions were highly susceptible Three resistant and highly resistant accessions were namely 85-9-73, DS/005 H, and FJ/004 He could inhibit F. oxysporum growth about 23.40- 32.43 mm and its discolorisation about 0.0-13.4%.
Permintaan Kopi Biji Indonesia di Pasar Internasional
Authors: Manalu Doni Sahat Tua , Harianto Harianto , Suharno Suharno , Hartoyo Sri
Published: July 2020

Kopi merupakan salah satu komoditas unggulan perkebunan Indonesia setelah kelapa sawit, karet dan kakao dengan jumlah ekspor kopi yang lebih tinggi dibandingkan dengan konsumsi domestik. Tujuan penelitian adalah menganalisis faktor-faktor yang memengaruhi permintaan kopi biji Indonesia di pasar Internasional. Metode analisis data yang digunakan pada penelitian ini adalah model Linear Approximate Almost Ideal Demand System (LA/AIDS) dengan menggunakan data time series dari tahun 1995 hingga 2017 dengan HS 090111. Hasil penelitian menunjukkan bahwa faktor-faktor yang memengaruhi permintaan kopi biji Indonesia di Amerika Serikat adalah harga kopi row, Carea NTM, di Jepang adalah harga kopi Vietnam, populasi Jepang dan NTR Jepang terhadap Dollar, di Jerman adalah harga row dan Carea NTM. Kopi Indonesia bersifat elastis di negara importir utama Amerika Serikat, Jepang dan Jerman. Berdasarkan nilai elastisitas silang kopi Indonesia bersifat inelastis, kopi Indonesia bersifat komplementer dengan kopi  Vietnam di pasar Amerika Serikat, sementara di pasar Jepang dan Jerman bersifat substitusi.
DETECÇÃO DAS OCORRÊNCIAS DE FOCOS DE QUEIMADAS E PRODUÇÃO DE MAPAS DE CALOR EM TIMON, MA
Authors: Marques Rafael Jose , Sobrinho Werton Francisco Rios da Costa
Published: July 2020

O Brasil atualmente passa por uma expansão nas atividades do agronegócio e ao mesmo tempo, mantém as pequenas atividades agrícolas que permanecem ativas, e ambas as atividades ainda se utilizam da técnica mais rudimentar de limpeza de área para plantio e ou para pasto para criação de animal, a prática do fogo, a queimada. Neste âmbito, o Instituto Nacional de Pesquisas Espaciais (INPE) vem cada vez mais sendo relevante com um sistema de detecção de queimadas a partir de imagens de sensores a bordo de satélites polares e geoestacionários. Assim, os chamados focos de calor são detectados e esses dados são utilizados para mapeamentos, controle e prevenção. Neste sentido este trabalho pretende trazer dados das ocorrências no município de Timon (MA), entre os anos de 2014 a 2018, e nestes 5 (cinco) anos foram detectados cerca de 6.405 mil focos de queimadas, identificados pelo INPE. O conhecimento das causas e da frequência desses ocorridos é de extrema importância, principalmente levando-se em consideração que o ponto de partida para a elaboração dos planos de prevenção, é saber quem (ou o que) iniciou o fogo. Assim, este trabalho propõe validar e entender a relação dos focos de calor obtidos pelo INPE e queimadas realmente ocorridas, do município. Analisando os focos de calor disponibilizados pelo INPE.
ATLAS GEOAMBIENTAL E PONTOS GEODIDÁTICOS DA BACIA DO RIO DAS ANTAS (PR): SUBSÍDIOS AO ENSINO DE GEOGRAFIA
Authors: Matias Larissa Daniele , França da Silva Julio Manoel
Published: July 2020

O artigo apresenta os resultados de projeto de iniciação cientifica voltado à educação geográfica, visando a elaboração de materiais e recursos interpretativos dos aspectos geoambientais da Bacia do Rio das Antas (PR). Foram produzidos mapas temáticos e selecionados pontos geodidáticos como apoio ao ensino de geografia na educação básica, disponibilizando materiais e informações físico-ambientais da bacia para docentes e discentes do ensino fundamental e médio. A incorporação dos pontos geodidáticos possibilitou que alguns aspectos físicos da área de estudo fossem avaliados em escala detalhada, apresentando significativo potencial para análises geográficas em um contexto espacial local, voltado a atividades escolares.
NOTA EDITORIAL: REVISTA GEONORTE, V.11, N.37, JAN-JUN, 2020
Authors: Silva Neto João Cândido André da
Published: July 2020

É com grande satisfação que publicamos o novo número da REVISTA GEONORTE, V.11, N.37, JAN-JUN, 2020. Gostaríamos de agradecer a todos autores e autoras pelas contribuições, que consolidam a Revista Geonorte no âmbito nacional. Não poderíamos deixar de agradecer os pareceristas do conselho científico, pelo trabalho cuidadoso e de excelência que tem sido incorporado à Revista Geonorte. O atual número da REVISTA GEONORTE apresenta dezesseis artigos científicos que tangem o temário da Geografia e áreas afins, apresentando contribuições científicas de todas regiões do Brasil, além de uma entrevista.
Status of AI-enabled Clinical Decision Support Systems Clinical Implementations in China
Authors: Ji Mengting , Chen Xiaoyun , Genchev Georgi Z. , Xu Ting , Wei Mingyue , Yu Guangjun
Published: July 2020

The authors have withdrawn this preprint due to author disagreement.
Effects of Vitamin D Supplementation on Female Vitamin D Deficient Teenagers: A Randomized Clinical Trial
Authors: Ahi Salma , Gholami Fatemeh , Hatami Naser , Golabi Fatemeh
Published: July 2020

Background: Vitamin D deficiency is one of the most prevalent disorders worldwide. Considering the magnitude of growth in adolescence, the aim of this study was to ascertain the prevalence of vitamin D deficiency and discover the association between anthropometric indices and vitamin D levels and the effect of vitamin D treatment on anthropometric indices in adolescent girls. Method: we performed this randomized clinical trial study (approved by Iranian Registry of Clinical Trials with code of IRCT20200615047785N2) conducting 313 high school girl students in a random cluster sampling from Jahrom city schools. Blood samples were collected from participants to determine the serum level (OH) D25. We divided vitamin D deficient patients into two groups: control who received placebo (n=150) and intervention group (n=150) who were prescribed one tablet of 50,000 units of vitamin D per week for eight weeks. Anthropometric indices of participants were measured before and after the intervention. Datas were analyzed by SPSS software version 19.Results: The prevalence of vitamin D deficiency was 95%. Body mass index had no significant difference before the intervention in both groups (P = 0.76). After intervention in the case group, body mass index increased significantly (P = 0.01), but there was no significant difference in the control group after treatment (P = 0.42). There was no significant difference in waist circumference, height and weight before and after the intervention in both groups (P > 0.05). There was also a weak but significant correlation between height, weight, and baseline 25OHD levels of participants.Conclusion: The results of this study showed that there is a reverse and significant relationship between height and weight index with 25OHD. Further monitoring and prolonged studies with extended follow ups might improve the anthropometric parameters after treatment.
SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 elicits immunogenicity in baboons and protection in mice
Authors: Tian Jing-Hui , Patel Nita , Haupt Robert , Zhou Haixia , Weston Stuart , Hammond Holly , Logue James , Pornoff Alyse , Norton James , Guebre-Xabier Mimi , Zhou Bin , Jacobson Kelsey , Maciejewski Sonia , Khatoon Rafia , Wisniewska Malgorzata , Moffitt Will , Kluefel-Stahl Stefanie , Ekechukwu Betty , Papin James , Boddapati Sarathi , Wong C. Jason , Piedra Pedro , Frieman Matthew , Massare Michael , Fries Louis , Bengtsson Karin Lovgren , Stertman Linda , Ellingsworth Larry , Glenn Gregory , Smith Gale
Published: July 2020

The COVID-19 pandemic continues to spread throughout the world with an urgent need for a safe and protective vaccine to effectuate herd immunity to control the spread of SARS-CoV-2. Here, we report the development of a SARS-CoV-2 subunit vaccine (NVX-CoV2373) produced from the full-length spike (S) protein, stabilized in the prefusion conformation. Purified NVX-CoV2373 S form 27.2 nm nanoparticles that are thermostable and bind with high affinity to the human angiotensin-converting enzyme 2 (hACE2) receptor. In mice and baboons, low-dose NVX-CoV2373 with saponin-based Matrix-M adjuvant elicits high titer anti-S IgG that is associated with blockade of hACE2 receptor binding, virus neutralization, and protection against SARS-CoV-2 challenge in mice with no evidence of vaccine-associated enhanced respiratory disease (VAERD). NVX-CoV2373 vaccine also elicits multifunctional CD4+ and CD8+ T cells, CD4+ T follicular helper T cells (Tfh), and the generation of antigen-specific germinal center (GC) B cells in the spleen. These results support the ongoing phase 1/2 clinical evaluation of the safety and immunogenicity of NVX-CoV2327 with Matrix-M (NCT04368988).
Landslide in rocks of Jodhpur Group at Masuria Hill in Jodhpur, Western Rajasthan, India: Its causes and threat to significant Georesources
Authors: Mathur Saurabh , Sudhanshu  , Singh Suraj Kumar , C.P Khichi , Mathur S. C.
Published: July 2020

The ever first disastrous landslide at Masuria Hill (MH) damaged many houses and properties on 4th October 2019 in surrounding residential colonies of Masuria area in the Jodhpur city, Western Rajasthan India. Present landslide not only created panic among people but also damaged properties and significant georesources which is a serious concern for future. Geologically, MH is represented by rhyolite of Malani igneous suite (MIS) of Cryogenian age which is overlain by siliciclastic rocks of Jodhpur Group (JG) of Ediacaran age of Marwar Supergroup (MSG). Landslide occur in horizontally disposed rocks of Umed Bhawan Formation (UBF) of JG. UBF is divided into 4-18m thick clay dominated soft sediments zone with sheet and release joints at the base. It is followed by 24-72m thick rigid sand zone having orthogonal jointing. This disposition of soft and rigid pattern of sedimentation of UBF is identified as the key horizons responsible for the landslide with shale horizon as the failure plane. Causes of landslide can be explain based on the model of BPSZ (Bedding Parallel Shear Zone). BPSZ is attributed to three main mechanisms: liquefaction, mass wasting and shear stresses that caused the landslide at MH. Study further reveal that residential area surrounding MH and other seven hills having similar geological disposition are under great threat to future landslide in Jodhpur. Paper also embodies characteristics of georesources having educational and cultural values which are under great threat to landslide along with appropriate hazard mitigation measures.
Podoplanin-mediated platelet activation promotes proliferation and invasion of colon cancer cells
Authors: Qian Weihua , Zhang Yonghua , Pan Yingying , Tao Min
Published: July 2020

Background: Recent studies have shown that podoplanin is highly expressed in many tumors, suggesting that podoplanin may be related to the invasion and metastasis of malignant tumors. A potential mechanism by which podoplanin promote tumor invasion and metastasis is podoplanin-mediated platelet aggregation and activation.Methods: The expression of podoplanin in colon cancer LOVO cell line and lung adenocarcinoma cell line A549 was detected by immunoblotting. The above cells were co-cultured with washed mouse platelets. The platelet aggregation meter was used to determine the platelet aggregation rate and observe the cell morphology. Immunofluorescence staining and immunoblotting were used to detect the expression of EMT-related factors and the phosphorylation level of Smad2/3 downstream of the TGF-β signal; and then the matrigel-coated transwell chamber invasion test was used to evaluate the invasion ability of tumor cells. Lentiviruses targeting human podoplanin shRNA were constructed to infect colon cancer LOVO cells to generate cell lines with stable podoplanin knockdown, and the above experiments were repeated. Results: The colon cancer LOVO cell line with positive podoplanin expression had platelet aggregation activity, and the platelet aggregation activity of colon cancer LOVO cell line disappeared when anti-podoplanin monoclonal antibody MS-140 was added. However, no podoplanin expression and platelet aggregation activity were detected in lung adenocarcinoma cell line A549. When colon cancer LOVO cell-platelet reactant supernatant was added to colon cancer LOVO cell culture, the morphology of colon cancer LOVO cells showed EMT characteristics. Immunoblot showed that E-cadherin was down-regulated in colon cancer LOVO cells, while Vimentin And N-cadherin expression are upregulated. However, in lung adenocarcinoma A549 cells, there were no changes in EMT morphology and EMT factors. Immunoblot and ELISA showed that colon cancer LOVO cells with positive expression of podoplanin released TGF-β after aggregating with platelets, activated the TGF-β/Smad2/3 signaling pathway, and induced EMT and increased invasiveness of colon cancer LOVO cells. Treating colon cancer LOVO cells with TGF-β antibodies and TGF-β receptor inhibitors, or using LOVO cell lines with podoplanin knockdown, and repeating the above experiments suggest that platelet aggregation activity disappears and tumor cells EMT are eliminated, and The ability to invade is reduced. Conclusions: Podoplanin-mediated platelet activation plays an important role in colon cancer invasion and metastasis; its possible mechanism is that colon cancer LOVO cells with positive podoplanin expression react with platelets, activate platelets to release TGF-β, and activate TGF-β / Smad2 / 3 Signaling pathway induces EMT in colon cancer LOVO cells and enhances tumor cell proliferation and invasiveness.
Repurposing inhibitors for SARS-CoV2 main protease
Authors: Sharp Kumar
Published: July 2020

SARS-CoV2 main protease is important for viral replication and one of the most potential targets for drug development in this current pandemic. Drug repurposing is a promising field to provide potential short-term acceptable therapy for management of coronavirus till a specific anti-viral for coronavirus is developed. In-silico drug repurposing screening is the current fastest way to repurpose drugs by targeting active sites in fraction of seconds. In this study, SARS-CoV2 main protease is being targeted by 1050 FDA-approved drugs to inhibit its activity thereby interfering with viral replication. Chemotherapeutic drugs and anti-retroviral drugs have shown potential binding as inhibitor. In-vitro and clinical trials required to establish final fact.
The Determination of Correlation Between Stature and Foot Dimensions in Iranian Population
Authors: Moshkdanian Ghazaleh , Shahreza Parvaneh Behi , Rafiyan Mahdi , Mokhtari Tahmineh , Abolhasannejad Vahideh , Mianehsaz Elahe
Published: July 2020

Background: Estimation of stature from measurements of different human parts is significantly considered in forensic medicine to identity unknown individuals. Since stature data is dependent on different causes such as age, race, genetics, geographical location and climate condition so it is needed to find a relationship among different people. This study was carried out to evaluate stature from foot parameters in Najafabad, a city in Iran.Method: A total number of 206 volunteer adults comprising 106 males and 100 females between the ages of 19 - 38 were recruited for the study and measurements of stature, foot length, foot width, medial arch height, lateral malleolus height, medial malleolus height, and navicular height were recorded.Results: Linear regression models were used to estimate stature. The results indicated a positive correlation between stature and foot measurements. Among all parameters, left foot length and right foot width showed the most (r=0.819) and the least (r=0.551) relationship with stature, respectively.Conclusion: A strong correlation between stature and all foot dimensions were found.
MicroRNA-154 Expression is Associated With The Prognosis in Non-Small Cell Lung Cancer.
Authors: Zhao Yue , Kong Xiangjun , Wang Hongbing
Published: July 2020

Background: MicroRNAs are noncoding RNAs that regulate cellular processes during the progression of tumors. Among various microRNAs, MicroRNA-154 (miR-154) has been reported to be involved in many critical processes of human malignancies. This study aimed to evaluate the significance and prognostic value of miR-154 in human non-small cell lung cancer (NSCLC).Methods: A total of 144 NSCLC tissues samples and matched non-tumor adjacent tissues specimens were obtained from NSCLC patients and the quantitative real-time PCR (qRT-PCR) was performed to investigate expression levels of miR-154. The correlation between miR-154 expression and survival outcomes of NSCLC patients was performed by Kaplan-Meier analysis, univariate and multivariate analysis.Results: MiR-154 expression was significantly decreased in NSCLC tissues compared with that in matched non-tumor adjacent tissues (P<0.001). In addition, low expression of miR-154 was demonstrated to be associated with tumors size, TNM stages and distant metastasis of NSCLC patients Survival analysis revealed that patients with low expression of miR-154 showed significantly lower survival rate for OS, DFS and RFS, respectively (all, log rank test, P<0.001) and miR-154 could be an independent prognostic indicator for NSCLC patients.Conclusion: The results suggest that miR-154 has the clinical significance in the progression of NSCLC and could be a potential prognostic biomarker for NSCLC patients.
Methodologische und methodische Vorüberlegungen
Authors: Rau Franco
Published: July 2020

Der zweite Teil der vorliegenden Arbeit dient dem Zweck, die methodologischen Grundannahmen und Prinzipien gestaltungs- und entwicklungsorientierter Bildungsforschung darzustellen (Kap. 2) und die forschungsmethodischen Entscheidungen systematisch zu dokumentieren und nachvollziehbar zu begründen (Kap. 3). Um zu verdeutlichen, dass pädagogische Disziplinen häufig mit unterschiedlichen Erwartungshaltungen konfrontiert sind, erfolgt zu Beginn eine Betrachtung von Wissenschaft und Praxis als zwei unterschiedliche Referenzsysteme. Es wird gezeigt, dass je nach Perspektive unterschiedliche Massstäbe zur Bewertung von Forschungsprojekten und -ergebnissen existieren (Kap. 2.1). Im nächsten Schritt wird die Frage diskutiert, inwiefern gestaltungs- und entwicklungsorientierte Forschungsansätze sich zwischen den zwei skizzierten Referenzsystemen verorten lassen und in welcher Weise versucht wird, den Anforderungen der Praxis einerseits sowie der scientific community anderseits zu genügen (Kap. 2.2). Nach einer vergleichenden Betrachtung von drei ausgewählten Ansätzen (Kap 2.3) erfolgt eine Zusammenfassung und Diskussion relevanter Aspekte (Kap. 2.4). Auf Basis der vorangegangen Überlegungen wird die Konzeption und Realisierung des vorliegenden Projektes in Form einer entwicklungsorientierten Bildungsforschung konkretisiert (Kap. 3.1). Die leitende Fragestellung wird vorgestellt und hinsichtlich drei verschiedener Forschungsperspektiven unterschieden (Kap. 3.2). Daran anknüpfend werden die verwendeten Forschungsmethoden zur Datenerhebung (Kap. 3.3) sowie zur Analyse und Auswertung (Kap. 3.4) beschrieben und begründet. Zum Abschluss erfolgt eine Zusammenfassung der forschungsmethodischen Überlegungen (Kap. 3.5).
Erste Erkenntnisse und Modifikation des Entwurfs
Authors: Rau Franco
Published: July 2020

Der fünfte Teil der Arbeit bündelt und diskutiert zunächst die empirischen Erkenntnisse der ersten Erprobung (Kap. 8) und skizziert darauf aufbauend die entwickelten Modifikationen der Lernsituationen sowie des gesamten Seminarkonzeptes (Kap. 9). Dafür erfolgt die Interpretation der empirischen Ergebnisse auf mikrodidaktischer Ebene mit zwei Schwerpunkten: (1.) Metaphern als Artikulations- und Reflexionsanlässe (Kap. 8.2) und (2.) die Mitgestaltung eines Wikibooks als Erfahrungs- und Reflexionsmöglichkeit zur medienpädagogischen Professionalisierung (Kap. 8.3). Zudem erfolgt eine Diskussion der Geltungsbegründung der gewonnenen Erkenntnisse unter Berücksichtigung forschungsmethodischer Gütekriterien (Kap. 8.4). Zur Modifikation des Entwurfes werden ausgewählte Lernsituationen auf Basis der gewonnen Erkenntnisse weiterentwickelt (Kap. 9). Es erfolgt die Darstellung didaktischer Veränderungen hinsichtlich drei exemplarisch ausgewählter Lernsituationen: Visualisierung von Metaphern als neue Reflexionsmöglichkeit (Kap. 9.2.1), Modus der Gruppenbildung als Mitgestaltungsmöglichkeit (Kap. 9.2.2) und Wikibooks als offenes und veränderbares Lehr- und Lernmaterial (Kap. 9.2.3). Abschliessend wird die Modifikation des Phasenkonzeptes skizziert (Kap. 9.3) und eine Zusammenfassung des Kapitels formuliert (Kap. 9.4).
Fazit: Entwicklungspotenziale von Lernsituationen mit Metaphern und Wikibooks
Authors: Rau Franco
Published: July 2020

In Form einer entwicklungsorientierten Bildungsforschung erfolgte in den vorangegangen Kapiteln die Problematisierung der aktuellen Praxis zur integrativen Medienbildung in den erziehungswissenschaftlichen Studienanteilen des Lehramtsstudiums, der Entwurf einer neuen Praxis, die empirische Erprobung und wissenschaftliche Analyse des Entwurfs sowie eine zusammenfassende Interpretation der gewonnenen Erkenntnisse. In zwei Iterationen erfolgte eine systematische Untersuchung der Entwicklungspotenziale von Lernsituationen mit Metaphern und Wikibooks. Das abschließende Kapitel bündelt die Vielzahl der gewonnen Erkenntnisse der gesamten Arbeit. Zur Beantwortung der Forschungsfrage wird gezeigt, wie durch die Mitgestaltung eines öffentlichen Wikibooks in erziehungswissenschaftlichen Seminaren Situationen geschaffen werden können, um eine pädagogische Artikulations- und Reflexionsfähigkeit mit Metaphern (weiter) zu entwickeln und ein Lernen mit und über soziale Medien erfahrungsorientiert anzuregen und zu unterstützen.
Real opportunities for early prenatal diagnosis of omphalocele
Authors: O.L. Galkina, N.A. Savel'eva, I.V. Poddubnaya
Published: July 2020

During 5 years in the first trimester of pregnancy 82 cases of congenital anomalies of fetal development were
diagnosed, in 14 cases (17%) an omphalocele was found. An analysis of the results of prenatal examination of
fetuses with omphalocele in an isolated and combined version has been carried out. In 78% of cases, omphalocele
was combined with other fetal anomalies, most often with congenital heart defects (82%). The frequency of
chromosomal abnormalities in fetuses with omphalocele was 69%. Perinatal outcome in the case of early prenatal
omphalocele diagnosis is unfavorable in 93% of cases. Early prenatal diagnosis of omphalocele is possible in
100% of cases. Diagnosed in the first trimester of pregnancy, omphalocele is an indication for an extended
anatomical evaluation of the fetus with the aim of forming a clinical hypothesis and conducting timely optimal
prenatal counseling.
Possibilities of applying speckle tracking echocardiography to assess fetal
myocardial function. Part 2. Parameters to assess myocardial contractile
function
Authors: S.I. Buryakova, M.V. Medvedev
Published: July 2020

The article deals with the parameters to assess the contractile function of the myocardium and the potential
of applying speckle tracking echocardiography to study the fetal heart is presented.
Kürtçe, Türkçe ve İngilizce Atasözlerinde Azim, Başarı, Çalışkanlık, Kararlılık ve Tembellik İfadeleri
Authors: BABAYİĞİT Mehmet Veysi
Published: July 2020

Dil, etkileşim ve iletişim için temel araçtır ve dilin bir yansıması olan kültür, uluslararası gelenekleri ve yaşam biçimlerini ortaya çıkarır. Kısa ve anlamlı ifadelerin kalıpları olarak tanımlanan atasözleri farklı toplumlara özgüdür. Atasözleri gözlem, doğa, gelenek ve sosyal olaylara göre şekillenir. Her toplumun kendi atasözlerinin olmasına rağmen, farklı dillerde ve farklı topluluklarda benzer bağlamlarda atasözleri bulunmaktadır. Bu çalışmanın amacı Kürtçe, Türkçe ve İngilizcede; Azim, Başarı, Çalışkanlık, Kararlılık ve Tembellik bağlamında benzer atasözlerini incelemektir. Çalışmamız için veriler; kitap, makale ve dergilerde bulunan atasözlerinin bağlamsal benzerliklerinin belirlenmesi ile toplanmıştır. Çalışmanın yöntemi betimsel ile nitel olup, betimsel tarama modeline dayanmaktadır. Sonuçlar, her üç dilde Azim, Başarı, Çalışkanlık, Kararlılık ve Tembellik bağlamında atasözlerinin mevcut olduğu; ancak analiz edilen atasözlerinin, anadilde ve hedef dilde bağlamsal olarak benzer olanların aynı zamanda farklı kelimelerle ifade edildiğini göstermiştir. Üç dilde atasözlerini inceleyen benzer bir çalışmanın olmaması, bu çalışmanın etkileyici ve başarılı bir çalışma olacağını varsaymaktadır.
Concurrent removal of nitrate, fluoride and arsenic by mixed hydrous bismuth oxide from water
Authors: Ranjan Manish , Singh Prabhat Kumar
Published: July 2020

Clean and safe drinking water for all is an essential requirement for the world in which we want to live, but a majority of the population has been dependent on groundwater for its daily needs. Toxic contamination of such water could result in large-scale health effects. A great proportion of groundwater suffers from the problems of nitrate, fluoride, and arsenic contamination. Thus, the present research was aimed to remove these contaminants from the water. Hydrous bismuth oxide based adsorbents exhibited high adsorption capacities towards nitrate, fluoride and arsenic. However, As (V) removal was found to be more effective as compared to nitrate and fluoride. The removal efficiencies are 52, 72 and 92% for nitrate, fluoride and As (V), respectively, during concurrent removal of the same. Ion exchange with chloride ions was the probable mechanism for the concurrent removal of the above three anions from water. Scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) were used for the characterization of HBO12mix adsorbents. The results of the present study indicated that HBO12mix has the potential for concurrent removal of nitrate, fluoride, and As (V) from groundwater. Hence, hydrous bismuth oxide can be used in the drinking water treatment process at a domestic level.
Agent-based modelling of pedestrian responses during flood emergency: mobility behavioural rules and implications for flood risk analysis
Authors: Shirvani Mohammad , Kesserwani Georges , Richmond Paul
Published: July 2020

An agent-based model (ABM) for simulating the interactions between flooding and pedestrians is augmented to more realistic model responses of evacuees during floodwater flow. In this version of the ABM, the crowd of pedestrians have different body heights and weight, and extra behavioural rules are added to incorporate pedestrians’ states of stability and walking speed in floodwater. The augmented ABM is applied to replicate an evacuation scenario for a synthetic test case of a flooded shopping centre. Simulation runs are performed with increasingly sophisticated configuration modes for the pedestrians’ behavioural rules. Simulation results are analysed based on spatial and temporal indicators informing on the dynamic variations of the flood risk states of the flooded pedestrians, i.e. in terms of a commonly used flood Hazard Rating (HR) metric, variable walking speed, and instability due to toppling and/or sliding. Our analysis reveals significantly prolonged evacuation times and risk exposure levels as the stability and walking speed behavioural rules become more sophisticated. Also, it allows us to identify more conservative HR thresholds of pedestrian instability in floodwater, and a new formula relating walking speed states to the HR for stable pedestrians in floodwater. Accompanying details for software accessibility are provided.
Assessment of wastewater treatment plant effluent impact on the ecosystem of the river on the basis of the quantitative development of ciliated protozoa characteristic of the aeration tank
Authors: Babko R. , Pliashechnyk V. , Kuzmina T. , Danko Y. , Szulżyk-Cieplak J. , Łagód G.
Published: July 2020

The work is devoted to the task of simplifying the assessment of the effect of effluents from treatment facilities on the river hydrobiocenosis. The studies were carried out on the mountain river Uzh (Uzhgorod, Ukraine). Our approach to assessing the impact of waste treatment facilities on the river receiver is based on the estimate of the similarity of species composition and quantitative characteristics of populations of organisms from the aerotank and from the river. It is shown that the quantitative development of populations of species of ciliates from the aeration tank is a good indicator for assessing the degradation of organic matter coming with wastewater. The use of qualitative and quantitative characteristics of the protozoa from the wastewater treatment plant as a criterion for assessing the quality of the environment in the area of wastewater discharge showed their representativeness and effectiveness. The use of a limited number of species makes it possible to conduct an express assessment of the effect of effluents on receiving reservoirs for specialists working with activated sludge in the laboratories of treatment facilities.
Achieving enhanced biological nitrogen removal via 2450 MHz electromagnetic wave loading on returned sludge in anaerobic-anoxic-oxic process
Authors: Sang Wenjiao , Li Dong , Zhang Qian , Mei Longjie , Hao Shiwen , Feng Yijie , Jin Xi , Li Cuihua , Feng Yangyang , Singh Rajendra Prasad
Published: July 2020

To evaluate the enhancing of the biological nitrogen removal effectiveness by electromagnetic wave loading on returned sludge in the A/A/O reactor, some experiments were completed with the returned sludge loaded by 2,450 MHz electromagnetic wave. The excess sludge yield and pollutant removal effect of the system were evaluated. Results showed that stronger denitrification effect and less sludge yield were achieved. When 30% of the returned sludge was loaded by electromagnetic wave, the actual denitrification efficiency increased by 7% without dosage. The dissolution of carbon, nitrogen and phosphorus from loaded returned sludge was detected, thus providing the system with a supplemental carbon source of 4.6 g/d SCOD. The specific oxygen uptake rate of the oxic activated sludge increased by 14%, and the denitrification rate of the anoxic activated sludge increased by 29%. Illumina MiSeq analysis showed that the microbial richness increased obviously, and denitrifying bacteria (i.e. Dechloromonas, Zoogloea and Azospira, etc.) were accumulated.
Volume reduction and water reclamation of reverse osmosis concentrate from coal chemical industry by forward osmosis with an osmotic backwash strategy
Authors: Lu Jiandong , Wang Xiuheng
Published: July 2020

Coal chemical industry (CCI) generally utilizes reverse osmosis (RO) for water reclamation, which generates a highly concentrated stream containing refractory organic substances and high-concentration total dissolved solids (TDS). To address this issue, the present work focuses on volume reduction of RO concentrate (ROC) produced from CCI by forward osmosis (FO). We investigated the effects of membrane orientation and draw solution (DS) concentration on FO performance. Foulant removal was tested by using chemical cleaning, physical cleaning and osmotic backwash (OB). AL-FS (active layer facing feed solution) mode outcompeted AL-DS (active layer facing draw solution) mode, achieving a flux of 26.4 LMH, 92.5% water reclamation and energy consumption of 0.050 kWh·m−3 with 4 M NaCl as DS. The FO process was able to reject >98% SO42−, Mg2+and Ca2+, 92–98% Si and 33–55% total organic carbon (TOC). Ten-cycle (10 × 20 h) accelerated fouling test demonstrated approximately 30% flux decline in association with Si-containing foulants, which could be removed almost completely through OB with 97.1% flux recovery. This study provides a proof-of-concept demonstration of FO for volume reduction and water reclamation of ROC produced from CCI, making the treatment of ROC more efficient and more energy effective.