bluuebunny/crossref_metadata_2025 huggingface dataset:
DIGITALIZATION OF EDUCATION: RISKS AND PROSPECTS
Authors:   Karaganda University of Kazpotrebsoyuz, RYMBEKOV SULTAN , BLYALOVA ALUA ,   Karaganda University of Kazpotrebsoyuz
Published: June 2023

The article analyzes the problems of implementing digital learning at all levels of the education system in the modern era of cyber-socialization of society and the numerous problems, risks and prospects associated with this process. In the process of improving national education, modern technologies are acquiring an increasing role every year, the introduction of which contributes to the modernization and development of education, as well as to the improvement of the quality of training of future specialists and the convergence of education with science. At the same time, such technologies require a revision of existing approaches to educational activities, as well as an analysis of their impact on society and individual social groups. In this regard, the study of issues of digitalization of education and its social consequences seems to be a very relevant area of scientific research. The purpose of this study is to identify the main problems and determine the prospects for digitalization in the field of education.
SOME ISSUES OF APPLICATION OF ARTIFICIAL INTELLIGENCE TECHNOLOGY IN HIGHER EDUCATION
Authors:   JSC «M.S. Narikbayev KAZGUU University», TEMIRBEKOV ZHALGAS
Published: June 2023

Today, artificial intelligence technologies are widely used not only in the fields of information technology and engineering, but also in higher education. Artificial intelligence systems can make a significant contribution to the implementation of open and transparent selection, adaptive learning, the organization of the educational process, the development of inclusive education and other educational processes. But despite the existing advantages, the use of artificial intelligence technology carries some risks and depends on the development of infrastructure capacities. Nevertheless, in the educational process, artificial intelligence technologies will find increasing use, as it increases efficiency, cost-effectiveness and saves valuable time.
MANAJEMEN KEARSIPAN TENAGA KEPENDIDIKAN DALAM MENINGKATKAN LAYANAN ADMINISTRASI DI SMA MAJALAYA PUTRA KABUPATEN BANDUNG
Authors: Gustina Lestary , Hidayat Asep Taufik
Published: June 2023

Latar belakang penelitian ini adalah bahwa di zaman sekarang ini informasi menjadi kebutuhan mutlak bagi setiap instansi baik instansi pemerintah maupun swasta. Informasi juga diperlukan untuk mendukung proses kerja administrasi suatu lembaga khususnya di bidang pendidikan. Arsip adalah rekaman kegiatan atau peristiwa dalam berbagai bentuk dan media sesuai dengan perkembangan teknologi informasi dan komunikasi yang dibuat dan diterima oleh lembaga pendidikan dalam penyelenggaraan kehidupan berbangsa, berbangsa, dan bernegara. Sistem penyimpanan arsip yang baik dapat memudahkan pihak sekolah dalam melakukan kegiatan administrasi dalam melaksanakan tugasnya, sehingga pengelola arsip dapat menghasilkan informasi fisik dan arsip serta memelihara arsip terutama dengan pengawasan dan pengelolaan arsip sebagai sumber data dapat bermanfaat. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif, dengan tujuan untuk mendeskripsikan atau mendeskripsikan pengelolaan arsip tenaga kependidikan, serta fenomena-fenomena yang muncul di lokasi penelitian. Data yang dikumpulkan dalam penelitian ini adalah data yang diperoleh dengan cara wawancara, observasi dan studi dokumentasi. Agar hasil penelitian tersusun secara sitematis, langkah-langkah penulis dalam menganalisis data adalah terlebih dahulu memilih hal-hal yang pokok dan memfokuskan pada hal-hal yang penting. baik menyajikan data dalam bentuk brief, dan sejenisnya. Ketiga menarik kesimpulan guna menjawab rumusan masalah yang dirumuskan sejak awal. Berdasarkan hasil penelitian ini penulis menyimpulkan: (1) Pengelolaan kearsipan tenaga kependidikan dalam meningkatkan pelayanan administrasi di SMA Majalaya Putra sudah baik dan benar sesuai dengan prosedur yang dilaksanakan; (2) Faktor pendukung manajemen kearsipan tenaga kependidikan dalam meningkatkan pelayanan administrasi yaitu belum adanya teknologi modern ditambah pegawai yang sudah lama menjabat sebagai tenaga administrasi namun kendala yang dihadapi adalah letak sekolah yang rawan banjir, kurangnya peralatan kearsipan dan sarana prasarana fasilitas tempat khusus arsip; (3) Mengatasi kendala yaitu dengan memanfaatkan fasilitas yang ada dan membersihkan atau mengeringkan arsip yang masih bisa diselamatkan akibat banjir..
DAMPAK PEMBELAJARAN DI ERA NEW NORMAL DI MASA PANDEMI CORONA VIRUS DISEASE 2019 (COVID-19)
Authors: Rosmayati Siti , Maulana Arman
Published: June 2023

Metode penelitian deskriptif digunakan dengan memeriksa variabel dalam situasi yang terjadi secara alami melalui deskripsi dan interpretasi kondisi di mana variabel tersebut ditemukan Penelitian ini mengeksplorasi dampak dariÂ  New NormalÂ  pengajaran di antara 101 pendidik di jawa barat, para pendidik kebanyakan berusia 29 sampai 38 tahun, jenis kelamin paling banyak tenaga pendidik perempuan, dalam hal mengajar mahasiswa selama 10 tahun ke bawah di sekolah negeri. Dampak dari pengajaran New NormalÂ  diungkapkan melalui tantangan dalam sumber daya seperti koneksi internet yang sangat lambat dan atau tidak dapat diandalkan dan tidak stabil, ruang kelas online yang bising dan kurang privasi selama kelas online secara bersamaan, kurangnya Learning Management System (LMS) berlisensi/terdaftar untuk terus menerus mengadakan kelas online dan kurangnya komputer dan koneksi internet untuk beberapa tenaga pendidik. Para pendidik secara fisik siap dalam pengajaran New Normal,Â  tetapi tenaga pendidik tidak siap secara emosional, oleh karena itu tenaga pendidik lebih suka mengajar di ruang kelas daripada di kelas virtual. Dampak pada penyesuaian pendidik adalah dalam hal lingkungan siswa, kurikulum, strategi pengajaran, dan penggunaan teknologi. Usia, jenisÂ  kelamin, jenis Â sekolah dan tingkat siswa yang diajar oleh pendidik merupakan faktor-faktor yang mempengaruhi pengajaran siswa di era New Normal.
MARDHATILLAH SEBAGAI TUJUAN AKHIR PENDIDIKAN ISLAM
Authors: Suhendi Endi
Published: June 2023

Hidup bahagia merupakan dambaan setiap manusia, namun di manakah kebahagiaan itu dapat kita peroleh. Sebagian orang beranggapan dengan harta dia dapat hidup bahagia, sebagian yang lain beranggapan dengan jabatan yang tinggi lah dia dapat hidup bahagia dan ada pula yang beranggapan bahwa ilmu adalah sumber kebahagiaan hidup. Kekeliruan pandangan tentang sumber kebahgiaan telah mengakibatkan melencengnya paradigma manusia dalam menentukan tujuan hidupnya. Bagi manusia beriman tentu akan mengetahui bahwa sesungguhnya suber kebahagiaan hakiki bukan ada pada harta, jabatan, ilmu dan lain sebagainya melainkan ada pada keridhaan Allah swt. (mardhatillah). Oleh karena itu tujuan akhir dari kehidupan sorang mukmin tiada lain adalah menggapai ridha Allah swt. Implikasinya pada pendidikan Islam adalah mardhatillah harus menjadi tujuan akhir dari pendidikan Islam itu sendiri. Karena hakikat dari tujuan pendidikan Islam adalah membentuk manusia yang memiliki karakter ibadurrahman, yaitu manusia yang memiliki komitmen untuk menyembah Allah dan dia mampu memelihara keharmonisan dalam hubungan sesama manusia dan dengan makhluk Allah lainnya. Dan karakter itulah yang akan mendatangkan ridha Allah swt.
Pengembangan E-Modul IPA SMP Berbasis Socio Scientific Issues (SSI) : Systematic Review
Authors: Azizah Hanifah Putri , Ilhami Aldeva , Hafiza Nur
Published: June 2023

Perkembangan teknologi membawa perubahan dalam bidang pendidikan. Perubahan ditandai dengan terjadinya suatu proses produksi barang yang secara perlahan beralih dari tenaga manusia ke arah digital. Pembelajaran sains, peserta didik diharapkan mampu mengembangkan pengetahuan, proses berpikir dan sikap. Untuk mencapai itu semua, tentu harus dilengkapi dengan berbagai sarana ataupun alat berupa bahan ajar yang berguna untuk mempermudah proses belajar mengajar seperti e-modul. Penelitian ini bertujuan untuk mengidentifikasi e-modul IPA SMP berbasis socio scientific issues (SSI) melalui kajian literatur. Metode yang digunakan ialah tinjauan pustaka sistematis (Systematic Literature Review). Database yang digunakan untuk mencari literatur menggunakan dua digital library yaitu Google Scholar, Scopus dan Mendeley Web. Agar literatur yang dipilih relevan, pencarian menggunakan kata kunci “e-modul IPA SMP, isu sosiosaintifik dan socio scientific issues ”. Selanjutnya melakukan penyaringan untuk mendapatkan publikasi artikel ilmiah sejak tahun 2016 hingga 2021 yang membahas mengenai e-modul IPA SMP berbasis socio scientific issues (SSI) dengan kriteria inklusi dan eksklusi. Hasil penelitian dari 17 jurnal yang telah disintesis dengan rentang waktu 2016-2021, pengembangan e-modul IPA SMP dan isu sosiosaintifik atau socio scientific issues (SSI) lebih banyak mengukur keterampilan kemampuan mengenai pemahaman konsep, sedangkan materi yang lebih banyak diangkat yakni materi Ilmu Pengetahuan Alam, dimana materi yang diterapkan dalam penelitian tersebut lebih luas cakupannya.
PERKEMBANGAN KOGNITIF DAN PSIKOMOTORIK ANAK USIA DINI TERHADAP MODEL PEMBELAJARAN KOOPERATIF TERINTEGRASI STICKY NOTE
Authors: Irawan Ferry
Published: June 2023

Anak usia dini yang memasuki usia emas (golden age) harus dilatih untuk memahami setiap konsep dasar. Keterampilan kognitif adalah kecakapan ilmiah yang memegang peranan penting bagui anak usia dini agar mampu mengasosiasikan keterampilan dasar dengan kegiatan pembelajaran,.Tujuan penelitian untuk mengetahui pengaruh model pembelajaran Kooperatif terintegrasi stiky note terhadap pengenalan konsep dasar. Termasuk quasy experiment menggunakan Non equivalent pretest-posttest control group design. Total populasi 80 siswa dengan total tiga kelas. Sampel dalam peneltitian  dipilih dengan melakukan uji kesetran pada setiap kelas. Instrumen menggunakan angket yang  mengacuh pada indikator keterampilan dasar kognitif dan psikomotrik. Analisis menggunakan One Way Anacova Test dan hasilnya model pembelajaran kooperatif terintegrasi stiky note berpengaruh terhadap perkembangan kognitif dan psikomotorik pada anak usia dini secara dinamis/berkesinambungan.
HUBUNGAN ANTARA BEBAN KERJA DAN PERILAKU CARING PERAWAT
Authors: Herman Herman , Deli Putri
Published: June 2023

Latar Belakang: Meningkatnya keluhan tentang asuhan keperawatan yang buruk telah mendorong penyelidikan kemungkinan alasan untuk fenomena ini. Salah satu faktor yang mempengaruhi perilaku caring adalah lingkungan praktik, seperti beban kerja. Tujuan: Untuk menganalisis hubungan beban kerja dengan perilaku caring perawat Metode: Penelitian ini yaitu analitik korelasional dengan pendekatan cross sectional. Sampel dalam penelitian ini berjumlah 73 orang. sampel diambil dengan teknik purposive sampling. Hasil penelitian diuji dengan uji statistik Pearson dengan signifikansi α = <0,05 dengan program SPSS 23. Instrumen penelitian dengan menggunakan kuesioner beban kerja dan CBAS (Caring Behaviors Assessment Scale). Penelitian ini dilakukan di RS Bhayangkara Makassar. Hasil: Hasil uji korelasi Pearson dengan taraf kesalahan (α) = 0,05, diperoleh nilai p = 0,011. Ini berarti ada hubungan signifikan antara beban kerja dengan perilaku caring yang diterapkan oleh perawat. Kesimpulan: Semakin rendah beban kerja semakin memungkinkan bagi perawat menunjukkan perilaku caring dalam memberikan asuhan keperawatan.
Supporting Faculty’s Instructional Video Creation Needs for Remote Teaching
Authors: Dong Hanwen
Published: June 2023

In 2021, alongside seven colleges at the University of Idaho campus, the University of Idaho Library received an eGlass system (https://eglass.io) with funding from the Governor’s Emergency Education Relief Grant to expand faculty’s capacity to create instructional videos. The eGlass is a transparent glass whiteboard that allows instructors to write, draw, and annotate. It comes with a built-in camera that can capture instructors’ facial expressions and gestures while facing their remote students and allow better engagement. The eGlass is suitable for creating asynchronous instructional videos for flipped classrooms and integrating Zoom for synchronous online classes. This article details the eGlass equipment setup, studio space optimization, outreach efforts and initiatives, usage examples of early adopters, lessons learned during the first year of the eGlass deployment, and future considerations.
Tale of Two Tools
Authors: Jill Locascio  , Dejah Rubel
Published: June 2023

Consistent delivery of full-text content has been a challenge for libraries since the development of online databases. Library systems have attempted to meet this challenge, but link resolvers and early direct linking tools often fell short of patron expectations. In the last several years, a new generation of direct linking tools has appeared, two of which will be discussed in this article: Third Iron’s LibKey Discovery and Quicklinks by Ex Libris, a Clarivate company. Figure 1 shows the “Download PDF” link added by LibKey. Figure 2 shows the “Get PDF” link provided by Quicklinks. The way we configured our discovery interface, a resource cannot receive both the LibKey and Quicklinks PDF links. These two direct linking tools were chosen because they were both relatively new to the market in April 2021 when this analysis took place and they can both be integrated into Primo VE, the library discovery system of choice at the authors’ home institutions of SUNY College of Optometry and Ferris State University. Through analysis of the frequency of direct links, link success rate, and number of clicks, this study may help determine which product is most likely to meet your patrons’ needs.
Letter from the Editors
Authors: Varnum Kenneth J. , Kelly Marisha C.
Published: June 2023

Introduction to the June 2023 issue of Information Technology and Libraries with a summary of this issue's contents and updates on the journal's hosting migration plans, changes to editorial board membership, and our call for submissions.
IMPORTANT NOTE TO ALL READERS: Later this summer, ITAL is moving to a new provider. Other than the journal's URLs, nothing is changing. Now and in the future,  https://italjournal.org/ will get you to the journal’s front page. If you would like to receive an email when the September 2023 issue is published at our new location, create a user account by going to our current user registration page. Make sure your check the “Yes, I would like to be notified of new publications and announcements” box near the bottom of the sign-up page. When the September issue is available, you will be among the first to know.
Epidemiological characteristics and prevalence rates of research reproducibility across disciplines: A scoping review of articles published in 2018-2019
Authors: Cobey Kelly D , Fehlmann Christophe A , Christ Franco Marina , Ayala Ana Patricia , Sikora Lindsey , Rice Danielle B , Xu Chenchen , Ioannidis John PA , Lalu Manoj M , Ménard Alixe , Neitzel Andrew , Nguyen Bea , Tsertsvadze Nino , Moher David
Published: June 2023

Background:

Reproducibility is a central tenant of research. We aimed to synthesize the literature on reproducibility and describe its epidemiological characteristics, including how reproducibility is defined and assessed. We also aimed to determine and compare estimates for reproducibility across different fields.

Methods:

We conducted a scoping review to identify English language replication studies published between 2018 and 2019 in economics, education, psychology, health sciences, and biomedicine. We searched Medline, Embase, PsycINFO, Cumulative Index of Nursing and Allied Health Literature – CINAHL, Education Source via EBSCOHost, ERIC, EconPapers, International Bibliography of the Social Sciences (IBSS), and EconLit. Documents retrieved were screened in duplicate against our inclusion criteria. We extracted year of publication, number of authors, country of affiliation of the corresponding author, and whether the study was funded. For the individual replication studies, we recorded whether a registered protocol for the replication study was used, whether there was contact between the reproducing team and the original authors, what study design was used, and what the primary outcome was. Finally, we recorded how reproducibilty was defined by the authors, and whether the assessed study(ies) successfully reproduced based on this definition. Extraction was done by a single reviewer and quality controlled by a second reviewer.

Results:

Our search identified 11,224 unique documents, of which 47 were included in this review. Most studies were related to either psychology (48.6%) or health sciences (23.7%). Among these 47 documents, 36 described a single reproducibility study while the remaining 11 reported at least two reproducibility studies in the same paper. Less than the half of the studies referred to a registered protocol. There was variability in the definitions of reproduciblity success. In total, across the 47 documents 177 studies were reported. Based on the definition used by the author of each study, 95 of 177 (53.7%) studies reproduced.

Conclusions:

This study gives an overview of research across five disciplines that explicitly set out to reproduce previous research. Such reproducibility studies are extremely scarce, the definition of a successfully reproduced study is ambiguous, and the reproducibility rate is overall modest.

Funding:

No external funding was received for this work
Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
Authors: Castrillon Carlos , Simoni Lea , van den Broek Theo , van der Poel Cees , Akama-Garren Elliot H , Ma Minghe , Carroll Michael C
Published: June 2023

Affinity matured self-reactive antibodies are found in autoimmune diseases like systemic lupus erythematous. Here, we used fate-mapping reporter mice and single-cell transcriptomics coupled to antibody repertoire analysis to characterize the post-germinal center (GC) B cell compartment in a new mouse model of autoimmunity. Antibody-secreting cells (ASCs) and memory B cells (MemBs) from spontaneous GCs grouped into multiple subclusters. ASCs matured into two terminal clusters, with distinct secretion, antibody repertoire and metabolic profiles. MemBs contained FCRL5+ and CD23+ subsets, with different in vivo localization in the spleen. GC-derived FCRL5+ MemBs share transcriptomic and repertoire properties with atypical B cells found in aging and infection and localize to the marginal zone, suggesting a similar contribution to recall responses. While transcriptomically diverse, ASC and MemB subsets maintained an underlying clonal redundancy. Therefore, self-reactive clones could escape subset-targeting therapy by perpetuation of self-reactivity in distinct subsets.
Finding common connections
Authors: Santiago Ma Francesca M , Raulo Aura
Published: June 2023

Ecological associations among gut bacteria are largely consistent across hosts in a population of wild baboons.
Microbial community in buckwheat rhizosphere with different nitrogen application rates
Authors: Wang Dongsheng , Ren Haike
Published: June 2023

Microorganism plays a pivotal role in regulating sustainable development of agriculture. The excessive application of nitrogen fertilizer is considered to affect the microbial structure in many agricultural systems. The present study aimed to assess the impacts of nitrogen application rate on microbial diversity, community and functionality in rhizosphere of Tartary buckwheat in short-time. The nitrogen fertilizer was applied at rates of 90 kg (N90), 120 kg (N120) and 150 kg (N150) urea per hectare, respectively. The soil properties were measured chemical analysis and displayed no difference among treatments. Metagenome analysis results showed that the microbial diversity was not affected, but the microbial community and functionality were affected by the nitrogen application rate. According to the Linear discriminant analysis effect size (LEfSe) analysis, 15 taxa were significantly enriched in the N120 and N150 groups, no taxon was enriched in the N90 group. Kyoto Encyclopaedia of Genes and Genomes (KEGG) annotation results revealed that the genes related to butanoate and beta alanine metabolism were significantly enriched in the N90 group, the genes related to thiamine metabolism, lipopolysaccharide biosynthesis and biofilm formation were significantly enriched in the N120 group, and the genes related to neurodegenerative disease was significantly enriched in the N150 group. In conclusion, short-time nitrogen fertilizer application shifted the microbial community structure and functionality.
Cnidom in Ceriantharia (Cnidaria, Anthozoa): new findings in the composition and micrometric variations of cnidocysts
Authors: Garese Agustín , Goes Correa Fabiola , Acuña Fabián H. , Stampar Sérgio Nascimento
Published: June 2023

Background

Like all cnidarians, the subclass Ceriantharia (Cnidaria, Anthozoa) is known for producing cnidocysts, which mainly serve for prey immobilization, predator defense, and locomotion.

Aim

The present study aimed to understand the variability of the cnidom,i.e., the inventory of all cnidocyst types, in the ceriantharians (tube anemones)Ceriantheomorphe brasiliensis(10 individuals) andCerianthussp. (seven individuals).

Methods

In each individual, 30 intact cnidocysts of each identified type were measured in the following parts of tube anemones: marginal tentacles (four from each individual), labial tentacles (four from each individual), column, actinopharynx and metamesenteries. Each of these structures was divided into three levels (high, middle, and low) and the cnidom was analyzed. Statistical descriptive parameters (mean, standard deviation, minimum and maximum) of the sizes of all types of cnidocysts were calculated. The normality of the data for cnidocyst length was assessed using a Shapiro-Wilk test (α = 0.05). Based on the acceptance or rejection of the normality, either linear models or generalized linear models were used to evaluate variations in cnidocyst lengths. The normality of the cnidocyst length was tested by Shapiro-Wilk, and due to its rejection, generalized linear mixed models were applied to test the cnidocyst lengths variations.

Results

The analysis ofCeriantheomorphe brasiliensisrevealed 23 categories of cnidocysts, thereby expanding the understanding of its cnidome. The cnidoms ofCeriantheomorphe brasiliensisandCerianthussp. presented intraspecific variations, both qualitatively and in the lengths of cnidocysts. The cnidoms of the two species studied also showed qualitative intra-individual variations between different levels (high, middle, low) within each structure of the tube anemone (tentacles, actinopharynx, column and metamesenteries). Some cnidocyst types, such as atrichs from the column ofC. brasiliensis, presented a length gradient along the column, from larger lengths at the “low” level to smaller lengths at the “high” level.

Conclusions

The cnidom of a tube anemone could be better described if samples are taken at different levels of the structures, as observed inC. brasiliensis. In addition, we can conclude that the cnidocyst lengths of bothC. brasiliensisandCerianthussp. present intraspecific variation, which is coincident with that observed in actiniarian sea anemones. Moreover, as main conclusion, this work also proved that individuals of tube anemone species could present qualitative intra-structure variations in both the cnidom and cnidocyst lengths. This characteristic appears as an exception in cnidom variations, and has so far not been recorded even in the most studied actiniarian sea anemones. Finally, the intra-structure cnidocyst variations could reveal different functions of the different levels of a particular body part of the organisms.
Recovery From Otitis Media and Associated Factors Among 1- to 6-Year-Old Children in South India: A Longitudinal Study
Authors: Harinath Sathya , Lakshmanan Somu , James Saji , Maruthy Sandeep
Published: June 2023

Background and Objectives: This study was aimed at assessing recovery from otitis media (OM) and variables associated with it among 1- to 6-year-old children.Subjects and Methods: We assessed 87 children with OM otologically and audiologically. Medicines were prescribed, and medication compliance was ensured. The children were followed up after 3 months to judge the status of OM as resolved or recurrent. Data were statistically analyzed to derive the risk of recurrence of OM with effusion (OME) and acute OM by degree of hearing loss, type of tympanogram, age group, and sex.Results: The overall recurrence rate was 26%. The risk of recurrence was higher for OME (odds ratio [OR]=4.33; 95% confidence interval [CI]: 1.90 to 9.83); at AC auditory brainstem peak V responses up to 40 dBnHL (OR=5.20; 95% CI: 2.05 to 13), 50 dBnHL (OR=3.47; 95% CI: 0.5 to 23), and 60 dBnHL (OR=16.09; 95% CI: 4.36 to 1.2); in B (OR= 3.16; 95% CI: 1.36 to 7.33) and C tympanograms (OR=2.83; 95% CI: 0.70 to 11.41); and in the age group of 5-6 years (OR=8, 95% CI: 2.23 to 28). The risk of recurrence of OM did not differ between male and female patients.Conclusions: The rate of recurrence was comparable to or lower than that reported in the pediatric population of other countries. The findings suggest that children with OME, severe pathology, or age of 5-6 years require more attention and frequent monitoring to minimize the risk of recurrence.
Feasibility of Speech Testing Using Wireless Connection in Single-Sided Cochlear Implant Users
Authors: Bae Seong Hoon , Jung Youngrak , Hur Ji Hye , Kim Jeong Ha , Choi Jae Young
Published: June 2023

Background and Objectives: The speech tests used to evaluate language performance in patients with bilateral deafness (BiD) and cochlear implant (CI) are problematic if applied to patients with single-sided deafness (SSD) because normal ear hearing should be excluded. Thus, we investigated the feasibility of using wireless connection to evaluate speech intelligibility of the CI ear in patients with SSD.Subjects and Methods: Patients with BiD and SSD were administered the word recognition scores (WRS) and speech intelligibility tests using an iPadbased wireless connection and conventional methods. To exclude normal side hearing in patients with SSD, masking noise and “plugged and muffed” method were used in the WRS and speech intelligibility tests, respectively.Results: In patients with BiD, the WRS and speech intelligibility tests results using wireless connection and conventional methods were similar. In patients with SSD, the WRS using masking noise in the normal hearing ear was similar to that of using wireless connection. However, 3 of 11 patients with SSD showed under-masked results if using the “plugged and muffed” method.Conclusions: Speech intelligibility testing using wireless connection is a convenient and reliable method for evaluating CI performance in patients with SSD. The “plugged and muffed” method is not recommended for evaluating CI performance in patients with SSD.
Monitoring Viscosity of Polymer Products on the Reactor Tank Using IoT-based NodeMCU
Authors: Paduloh Paduloh
Published: June 2023

Viscosity is one of the critical parameters for polymer products; thus, monitoring the viscosity level is very important to know during the production process and production results. The Polymer Company recently suffered heavy losses due to an explosion in one of its reactor engines, the R306 engine. The investigation results show that the viscosity of the polymer is one of the causes of the heavy workload of the machine, when the viscosity is checked manually. This research was conducted based on these conditions, and a viscosity monitoring device was designed for the 306-tank product. The design used QFD visualization for product design and UML for information system design. In this study, polymer viscosity was measured using the falling ball method with an Infrared Sensor E18-D80NK to obtain the viscosity of polymer products. Viscosity data are configured directly with the Internet of Things using the NodeMCU microcontroller. The design results show that the tool can monitor the viscosity in the tank and provide polymer viscosity information in real-time, thus facilitating decision-making and increasing productivity.
Pellino 3 promotes the colitis‐associated colorectal cancer through suppression of IRF4‐mediated negative regulation of TLR4 signalling
Authors: Kim Young‐Mi , Kim Hye‐Youn , Ha Thi Huyen Trang , Kim Jooyoung , Lee Young Jae , Kim Seong‐Jin , Hong Suntaek
Published: June 2023

The incidence of colitis‐associated colorectal cancer (CAC) has increased due to a high‐nutrient diet, increased environmental stimuli and inherited gene mutations. To adequately treat CAC, drugs should be developed by identifying novel therapeutic targets. E3 ubiquitin‐protein ligase pellino homolog 3 (pellino 3; Peli3) is a RING‐type E3 ubiquitin ligase involved in inflammatory signalling; however, its role in the development and progression of CAC has not been elucidated. In this study, we studied Peli3‐deficient mice in an azoxymethane/dextran sulphate sodium‐induced CAC model. We observed that Peli3 promotes colorectal carcinogenesis with increased tumour burden and oncogenic signalling pathways. Ablation of Peli3 reduced inflammatory signalling activation at the early stage of carcinogenesis. Mechanistic studies indicate that Peli3 enhances toll‐like receptor 4 (TLR4)‐mediated inflammation through ubiquitination‐dependent degradation of interferon regulatory factor 4, a negative regulator of TLR4 in macrophages. Our study suggests an important molecular link between Peli3 and colonic inflammation‐mediated carcinogenesis. Furthermore, Peli3 can be a therapeutic target in the prevention and treatment of CAC.
Characteristics of “Daikoku‐bashira” and atrium of townhouses in Takayama—Correlation between the dimensions and position of the maximum section column and atrium
Authors: Tanaka Kiyoshi , Koresawa Noriko
Published: June 2023

The maximum section column of townhouses in Takayama can be classified into type A [earthen floor type] and type B [living space type]. The dimensions of maximum section columns tended to increase as the plane scale increased and the frontage widened. The atrium area tended to expand in the early Meiji period. We observed that the form of a maximum section column standing in one straight line at a rectangle atrium became the form of a maximum section column standing crossing‐axis in the plane of the structure of ridge direction and the span at irregularly shaped atrium, together complicating the plane and atrium shapes.
Impact of Soviet worker residential area design on Beijing No. 2 textile factory: Research of worker residential planning during the First Five‐Year Plan
Authors: Shao Shuai , Takamura Masahiko
Published: June 2023

This paper aims to examine the contents of professional architectural books on worker residential areas in the Soviet Union, analyzing proposals based on the Northeast China's experience during the First Five‐Year Plan. Despite sharing a common source for residential design, differences in regional and situational conditions result in diversity between China and the Soviet Union. By considering the plan for worker residential areas in Beijing and analyzing the case of the planned Beijing No. 2 textile factory in 1953, it can be concluded that China had already developed original residential planning ideas and methods during that period.
Fabricating Strong and Stiff Bioplastics from Whole Spirulina Cells
Authors: Iyer Hareesh , Grandgeorge Paul , Jimenez Andrew M. , Campbell Ian R. , Parker Mallory , Holden Michael , Venkatesh Mathangi , Nelsen Marissa , Nguyen Bichlien , Roumeli Eleftheria
Published: June 2023

Since the 1950s, 8.3 billion tonnes (Bt) of virgin plastics have been produced, of which around 5 Bt have accumulated as waste in oceans and other natural environments, posing severe threats to entire ecosystems. The need for sustainable bio‐based alternatives to traditional petroleum‐derived plastics is evident. Bioplastics produced from unprocessed biological materials have thus far suffered from heterogeneous and non‐cohesive morphologies, which lead to weak mechanical properties and lack of processability, hindering their industrial integration. Here, a fast, simple, and scalable process is presented to transform raw microalgae into a self‐bonded, recyclable, and backyard‐compostable bioplastic with attractive mechanical properties surpassing those of other biobased plastics such as thermoplastic starch. Upon hot‐pressing, the abundant and photosynthetic algae spirulina forms cohesive bioplastics with flexural modulus and strength in the range 3–5 GPa and 25.5–57 MPa, respectively, depending on pre‐processing conditions and the addition of nanofillers. The machinability of these bioplastics, along with self‐extinguishing properties, make them promising candidates for consumer plastics. Mechanical recycling and fast biodegradation in soil are demonstrated as end‐of‐life options. Finally, the environmental impacts are discussed in terms of global warming potential, highlighting the benefits of using a carbon‐negative feedstock such as spirulina to fabricate plastics.
Taming Zn Electrochemistry with Carbon Nitride: Atomically Gradient Interphase for Highly Reversible Aqueous Zn Batteries
Authors: Zhang Wenyao , Yao Qiushi , Wang Chao , Feng Renfei , Chen Ning , Zhu Junwu , Li Zhi
Published: June 2023

The irreversibility issuesof metallic zinc (Zn) anode of low Coulombic efficiency, persistent parasitic reactions, and severe dendrite growth remain a fundamental, century‐old challenge hindering the practical applications in rechargeable aqueous batteries. Herein, a promising atomically gradient solid electrolyte interphase (SEI) strategy is demmonstrated, in which the bottom sublayer of atomic Cu dispersed carbon nitride tightly anchors the whole SEI layer onto Zn anode, whereas the top carbon nitride uniformizes Zn2+ flux, facilitates Zn2+ diffusion, and detaches the reactive water molecules. Theoretical simulations and structural analysis confirm the strong interactions of this SEI with Zn2+ ions that launch an ion‐sieving effect to enable single Zn2+ ion conduction, and the porous and stiff feature accommodates the deposition stress and volume change under plating/stripping, ensuring consistent conformal contact on the substrate meanwhile suppressing the generation of Zn protuberant tips. Representative X‐ray computed tomography study demonstrates the failure mode of the Zn anodes under aqueous electrolyte and verifies the homogeneous Zn electrodeposition behavior and spatially compact metallic structure in the presence of this hydrophobic‐zincophilic SEI. Consequently, dendrite‐free Zn plating/stripping at ≈99.2% Coulombic efficiency for 200 cycles, steady charge–discharge for 2000 h, and impressive full cell cyclability are achieved.
High‐Resolution and Stable Ruddlesden–Popper Quasi‐2D Perovskite Flexible Photodetectors Arrays for Potential Applications as Optical Image Sensor
Authors: Wang Tao , Zheng Daming , Vegso Karol , Mrkyvkova Nada , Siffalovic Peter , Pauporté Thierry
Published: June 2023

The development of an efficient fabrication route to achieve high‐resolution perovskite pixel array is key for large‐scale flexible image sensor devices. Herein, a high‐resolution and stable 10 × 10 flexible PDs array based on formamidinium(FA+) and phenylmethylammonium (PMA+) quasi‐2D (PMA)2FAPb2I7 (n = 2) perovskite is demonstrated by developing SiO2‐assisted hydrophobic and hydrophilic treatment process on polyethylene terephthalate substrate. By introducing Au nanoparticles (Au NPs),  the perovskite film quality is improved and grain boundaries are reduced. The mechanism by which Au NPs upgrade the photoelectric quality of perovskite is mainly revealed by glow discharge‐optical emission spectroscopy (GD‐OES) and grazing‐incidence wide‐angle X‐ray scattering (GIWAXS). To further improve the photoelectric performance of the devices, a post‐treatment strategy with formamidinium chloride (FACl) is used . The optimized flexible PDs arrays show excellent optoelectronic properties with a high responsivity of 4.7 A W−1, a detectivity of 6.3 × 1012 Jones, and a broad spectral sensitivity. The device also exhibits excellent electrical stability even under severe bending and excellent flexural strength, as well as excellent environmental stability. Finally, the integrated flexible PDs arrays are used as sensor pixels in an imaging system to obtain high‐resolution imaging patterns, demonstrating the imaging capability of the PDs arrays.
Sea Cucumber‐Inspired Aerogel for Ultrafast Hemostasis of Open Fracture
Authors: Yu Xinyu , Han Fei , Feng Xian , Wang Xin , Zhu Yang , Ye Cong , Ji Minrui , Chen Zhichao , Tao Ran , Zhou Zhenyu , Wan Fuyin
Published: June 2023

The symptomatic management of hemorrhagic shock complicated by open fractures is a great challenge, because it is also complicated by complex wound bleeding, bacterial infection, and bone defects. Inspired by the water absorption and cross‐sectional microstructure of sea cucumbers, in this study, a new sea cucumber‐like aerogel (GCG) is proposed. Its aligned porous structure and composition can stop bleeding rapidly and effectively with a blood clotting index of 3.73 ± 1.8%. More importantly, the data of in vivo hemostasis test in an amputating rat tail hemostatic model (15.69 ± 2.45 s, 26.95 ± 8.43 mg) and liver puncture bleeding model (23.77 ± 2.68 s, 36.22 ± 16.92 mg) also indicate the excellent hemostatic performance of GCG. In addition, GCG also shows a significant inhibitory effect on S. aureus and E. coli, which can prevent the occurrence of postoperative osteomyelitis. Not only that, after filling in the bone defect, it is shown that this GCG aerogel completely degrades eight weeks after surgery and induces new bone ingrowth, achieving functional regeneration after hemostasis of an open fracture defect. Generally, because of its combination of hemostatic, antibacterial, and osteogenic activities, this new aerogel is a promising option for open fractures treatment.
Acoustodynamic Covalent Materials Engineering for the Remote Control of Physical Properties Inside Materials
Authors: Honda Satoshi , Oka Minami , Fuke Kazuki , Khuri‐Yakub Pierre T. , Pai Chi Nan
Published: June 2023

Advances in vat photopolymerization (VP) 3D printing (3DP) technology enable the production of highly precise 3D objects. However, it is a major challenge to create dynamic functionalities and to manipulate the physical properties of the inherently insoluble and infusible cross‐linked material generated from VP‐3DP without reproduction. The fabrication of light‐ and high‐intensity focused ultrasound (HIFU)‐responsive cross‐linked polymeric materials linked with hexaarylbiimidazole (HABI) in polymer chains based on VP‐3DP is reported here. Although the photochemistry of HABI produces triphenylimidazolyl radicals (TPIRs) during the process of VP‐3DP, the orthogonality of the photochemistry of HABI and photopolymerization enables the introduction of reversible cross‐links derived from HABIs in the resulting 3D‐printed objects. While photostimulation cleaves a covalent bond between two imidazoles in HABI to generate TPIRs only near the surface of the 3D‐printed objects, HIFU triggers cleavage in the interior of materials. In addition, HIFU travels beyond an obstacle to induce a response of HABI‐embedded cross‐linked polymers, which cannot be attainable with photostimulation. The present system would be beneficial for tuning the physical properties and recycling of various polymeric materials, but it will also open the door for pinpoint modification, healing, and reshaping of materials when coupled to various dynamic covalent materials.
Recent Advances and Opportunities in Low‐Dimensional Layered Perovskites for Emergent Applications beyond Photovoltaics
Authors: Ghosh Joydip , Parveen Sumaiya , Sellin P. J. , Giri P. K.
Published: June 2023

Layered metal halide perovskites have attracted enormous research attention over the last few years, befitting their unique optical and electronic properties. Low‐dimensional layered perovskites demonstrate great potential for various optoelectronic and sensing applications beyond photovoltaics. Herein, the recent progress and opportunities in 2D and quasi‐2D perovskites for light‐emitting diodes (LEDs), lasers, memristors, neuromorphic/synaptic applications, UV–vis photodetection, X‐ray detection, scintillators, and photocatalytic applications are reviewed. First, the crystal structure, characteristics, and fundamental properties of 2D layered perovskites are discussed. Recent efforts and developments of 2D and quasi‐2D metal halide perovskite for light‐emitting applications with excellent luminescence properties are reviewed. Unique properties of 2D perovskites, such as negligible leakage current due to restricted carrier transport, high stability, and hydrophobicity, make them viable for memristor devices. After discussing the memristor and neuromorphic devices using 2D perovskites, the outstanding performance of 2D perovskites in UV–vis photodetection including polarization‐sensitive photodetection is discussed. 2D perovskites recently proved as a superior candidate in X‐ray detection with high stability. Further, the scintillation properties of 2D perovskites for the detection of ionizing radiation are discussed. Finally, some of the very recent achievements and present future outlook, including exciting opportunities in this burgeoning field are highlighted.
ANO1‐Mediated Inhibition of Cancer Ferroptosis Confers Immunotherapeutic Resistance through Recruiting Cancer‐Associated Fibroblasts
Authors: Jiang Fangli , Jia Keren , Chen Yang , Ji Congcong , Chong Xiaoyi , Li Zhongwu , Zhao Feilong , Bai Yuezong , Ge Sai , Gao Jing , Zhang Xiaotian , Li Jian , Shen Lin , Zhang Cheng
Published: June 2023

The application of immunotherapy in gastrointestinal (GI) cancers remains challenging because of the limited response rate and emerging therapeutic resistance. Combining clinical cohorts, multi‐omics study, and functional/molecular experiments, it is found that ANO1 amplification or high‐expression predicts poor outcomes and resistance to immunotherapy for GI cancer patients. Knocking‐down or inhibiting ANO1 suppresses the growth/metastasis/invasion of multiple GI cancer cell lines, cell‐derived xenograft, and patient‐derived xenograft models. ANO1 contributes to an immune‐suppressive tumor microenvironment and induces acquired resistance to anti‐PD‐1 immunotherapy, while ANO1 knockdown or inhibition enhances immunotherapeutic effectiveness and overcomes resistance to immunotherapy. Mechanistically, through inhibiting cancer ferroptosis in a PI3K‐Akt signaling‐dependent manner, ANO1 enhances tumor progression and facilitates cancer‐associated fibroblast recruitment by promoting TGF‐β release, thus crippling CD8+ T cell‐mediated anti‐tumor immunity and generating resistance to immunotherapy. This work highlights ANO1's role in mediating tumor immune microenvironment remodeling and immunotherapeutic resistance, and introduces ANO1 as a promising target for GI cancers’ precision treatment.
Missense variant in SRCAP with distinct DNA methylation signature associated with non‐FLHS SRCAP‐related neurodevelopmental disorder
Authors: White‐Brown Alexandre , Choufani Sanaa ,   Care4Rare Canada Consortium, Weksberg Rosanna , Dyment David
Published: June 2023

Floating‐Harbor syndrome (FLHS) is a neurodevelopmental disorder (NDD) caused by truncating variants in exons 33 and 34 of the SNF2‐related CREBBP activator protein gene (SRCAP). Truncating variants proximal to this location in SRCAP result in a non‐FLHS SRCAP‐associated NDD; an overlapping but distinct NDD characterized by developmental delay with or without intellectual disability (ID), hypotonia, normal stature, and behavioral and psychiatric issues. Here, we report a young woman who initially presented in childhood with significant delays in speech and mild ID. In young adulthood, she developed schizophrenia. On physical examination, she had facial features suggestive of 22q11 deletion syndrome. After non‐diagnostic chromosomal microarray and trio exome sequencing (ES), a re‐analysis of trio ES data identified a de novo missense variant in SRCAP that was proximal to the FLHS critical region. Subsequent DNA methylation studies showed the unique methylation signature associated with pathogenic sequence variants in non‐FLHS SRCAP‐related NDD. This clinical report describes an individual with non‐FLHS SRCAP‐related NDD caused by an SRCAP missense variant, and it also demonstrates the clinical utility of ES re‐analysis and DNA methylation analysis for undiagnosed patients, in particular, those with variants of uncertain significance.
Tricomponent polymer aerogels containing cellulose nanocrystals and chitin nanofibers and their use in aerogel/hydrogel hybrids as fibrocartilage replacements
Authors: Irvin Cameron , Satam Chinmay C. , Shial Keya , Verma Prateek , Arroyo Nicole B. , Meredith Carson , Shofner Meisha L.
Published: June 2023

Considering the design of structures and materials for use as replacements for biological structures, polymer nanocomposites are desirable materials of construction since they have a large design space, allowing property customization. Biobased nanofibers are particularly suited for these applications since they have high specific mechanical properties and cytocompatibility. Motivated by these attributes, this work examines nanocomposite aerogels and an aerogel/hydrogel hybrid structure designed to mimic an intervertebral disc (IVD), with the aerogel and hydrogel serving as analogs for the annulus fibrosus and the nucleus pulposus, respectively. The aerogels and aerogel/hydrogel hybrid structure contain a mixture of biobased nanofibers, cellulose nanocrystals (CNCs) and chitin nanofibers (ChNFs), and a polyvinyl alcohol (PVA) matrix. Characterization of the structure and properties shows that the nanocomposite aerogels containing CNC/ChNF mixtures have larger pores and decreased mechanical properties as compared to aerogels containing only CNCs or only ChNFs. Building on these results, a hybrid comprised of a CNC/PVA aerogel and a CNC/ChNF/PVA hydrogel is constructed with mechanical properties similar to natural IVDs, providing initial validation of the hybrid concept for IVD replacements and pathways to customization through changing material composition in the aerogel and hydrogel and changing the aerogel and hydrogel fractions in the hybrid structure.
Dynamical Properties of T3Pb2Ch2 (T=Pd,Pt and Ch=S,Se) with Transition Metal Kagome Net
Authors: Basak Surajit , Kobiałka Aksel , Ptok Andrzej
Published: June 2023

Shandite with Ni3Pb2S2 chemical formula and Rm symmetry contains the kagome sublattice formed by transition metal atoms. Recent experimental results confirmed the possibility of successfully synthesizing Pd3Pb2Ch2 (Ch=S,Se) with the same structure. This paper theoretically investigates the dynamical properties of such compounds. Furthermore, we study the possibility of realizing Pt3Pb2Ch2 with the shandite structure. This study shows that the Pd3Pb2Ch2 and Pt3Pb2S2 are stable with Rm symmetry. In the case of Pt3Pb2S2, there is a soft mode, which is the source of the structural phase transition from Rm to Rc symmetry, related to the distortion within the kagome sublattice. This study discusses realized phonon nodal lines in bulk phonon dispersions in upper frequency modes. It shows that the shandite structure can host phonon surface states, with a strong dependence on the type of surface. Additionally, chiral phonons with circular motion of the Pb atoms around the equilibrium position are realized.