bluuebunny/crossref_metadata_2025 huggingface dataset:
Familial multiple lipomatosis
Authors: Rabbiosi G , Borroni G , Scuderi N.
Published: July 2023

A clinical study was made of 14 cases of multiple symmetrical lipomata in two families. There were 7 female and 7 male patients. In one family the members affected were observed in four generations. The disease set in during the third or fourth decade of life. The lipomata ranged in size from that of a pea to that of a hen's egg. They were limited to the forearms and trunk were asymptomatic.
Assessment of chromium allergy: features of patch test reactions at electron microscopic resolution
Authors: Forslind B , Wahlberg JE.
Published: July 2023

The possible correlation of clinically recorded test reactions and morphological changes at electron microscopic resolution in human subjects allergic to chromate (CrVI) was investigated. The effect of simple occlusion and of vehicles, e.g. distilled water, an alkaline buffer, and petrolatum was also studied 72 hours after application. The results indicate that even simple occlusion causes reactive changes in living epidermal cells. These changes become conspicuous in occlusion with distilled water, more pronounced with petrolatum, and were destructive in the case of the alkaline buffer. Chromate solutions produced varying degress of morphological change but were less pronounced in a vehicle of distilled water, compared with the changes seen when the chromate was combined with the alkaline buffer. Destructive cellular changes were observed in the electron microscope even in sections from test ares where no macroscopical reactions were recorded. When the clinical evaluation of hypersensitivity was done 72 hours after the application of the patch test the morphological changes were too advanced to provide specific pathognomonic information.
The significance of chromate ingestion in patients allergic to chromate
Authors: Kaaber K , Veien NK.
Published: July 2023

A double-blind study was carried out to demonstrate the significance of chromate ingestion in the persistence of chromic chromate dermatitis. Each of 31 chromate-allergic patients was given one tablet containing 7.1 mg potassium dichromate, plus a placebo tablet. The dermatitis of 11 of the 31 patients flared after the ingestion of chromate, but not after placebo. 3 patients had equivocal reactions to both tablets; the dermatitis worsened in 2 patients following ingestion of the placebo but not after the chromate tablet. No statistically significant difference could be found between reactivity to chromate and eczema of dyshidrotic morphology. Nor was it possible to correlate the degree of patch test reactivity to the reaction following chromate ingestion. It is concluded that a low-chromate diet is of value in the management of patients with chronic chromate dermatitis.
Bleomycin: effects upon mammalian epidermal DNA synthesis
Authors: Gilmartin ME , Epner S , Lasky L , Freedberg IM.
Published: July 2023

The effects of bleomycin upon epithelial DNA synthesis have been evaluated in a keratinizing tissue culture line and following topical application on intact mouse epidermis. In both models, bleomycin inhibited epithelial DNA synthesis after prolonged exposure of the tissue to large doses of the polypeptide antibiotic. The effect is probably limited by the penetration of bleomycin through epithelial cell membranes. Inhibition of epidermal DNA synthesis was also observed in non-treated animals subjected to restraint and/or partial starvation. These conditions, which are commonly associated with studies of topical therapeutic agents, must, therefore, be carefully controlled.
Pruritogenic activity of prostaglandin E2
Authors: Hägermark O , Strandberg K.
Published: July 2023

The itch and erythematous responses induced by intradermal injection of histamine and PGE2 were studied in human skin. Both compounds produced a sensation of itch. The histamine-elicited flare reached a maximum in 3 min and had disappeared after 1 hours. PGE2 induced a similar flare reaction initially, but it was gradually replaced by a smaller, dusky and well delimited erythema. The itch and the flare-like erythema induced by either histamine or PGE2 were alleviated when the subjects were pretreated with the antihistaminic drug chlorcyclizine, thus indicating that at least part of the PGE2 response may be mediated via histamine release. However, when given combined in a mixture, histamine and PGE2 elicited itch of longer duration and flare of larger area than could be accounted for by simple additive histamine effects. Thus, PGE2 seems to potentiate the itch and flare responses induced by histamine in human skin.
Reticular erythematous mucinosis syndrome: report of a case
Authors: Dal BL , Larsen TE.
Published: July 2023

A 47-year-old man with erythematous, maculopapular rash on the chest and the back. Histology showed perivascular infiltration of lymphocytes, especially around hair follicles, and alcian green positive deposits in the dermis. Some improvement was achieved by treatment with 200 mg oxychloroquine sulphate (Plaquenil, Winthrop) twice daily.
Studies on guinea pig skin cell cultures. VI. Growth kinetics of epidermal keratinocytes and dermal fibroblasts
Authors: Delescluse C , Regnier M , Opatowski L , Prunieras M.
Published: July 2023

The growth kinetics of epidermal keratinocytes (EK) and dermal fibroblasts (DF) have been determined by four different methods: incorporation of 3H-thymidine into DNA (3H-microgram DNA ratio); 3H-thymidine/14C amino acid incorporation ratio (3H:14C ratio); 3H-thymidine labelled nuclei, and colchicine-blocked metaphase counts. The growth curve of EK was no different when plotted with the 3H:14C ratio than with the 3H-microgram DNA ratio. However, this was not true for DF. The replacement of sodium bicarbonate with Hepes buffer in the culture medium did not greatly affect the shape of the EK growth curve, whereas the DF growth curve became diphasic instead of monophasic. The elimination of mature (differentiated) keratinocytes from the very onset of EK culture had a profound effect on the EK growth curve. DNA synthesis peaked at day 1 in cultures without, instead of day 9 in cultures with differentiated cells. Furthermore, mitotic activity did not show up before day 6. This suggests that (i) EK in culture are sensitive to the G1 inhibitor released by differentiated epidermal cells, and (ii) they remain in G2 for about 5 days. Thus, EK in culture seem to continue to be susceptible, as in vivo, to homeostatic regulation through the action of G1-G2 inhibitors.
Delayed hypersensitivity and febrile acne conglobata
Authors: Palatsi R.
Published: July 2023

Delayed hypersensitivity reactions were investigated in 5 patients with febrile acne conglobata. Each of them had febrile periods, large abscesses and leukocytosis. They reacted negatively to tuberculin 10 TU/ml, to Schick toxin, to oidiomycin, to trichophytin as well as to 25 common contact allergens. DNCB did not induce sensitization in those 4 patients in whom it was carried out. However, the transforamtion of lymphocytes by phytohaemagglutinin (PHA) was normal. Five of 7 control patients with cystic or ordinary acne had positive tuberculin test reactions and 3 of them were sensitized to DNCB.
Photodynamic aspects of some metal complexes
Authors: Wennersten G.
Published: July 2023

The potential phototoxic capacity of some metal compounds of clinical significance in dermatology has been investigated by means of the photohemolysis technique. No photosensitized hemolysis of erythrocytes was observed with the chromium, nickel, copper and cobalt compounds studied. On the contrary, nickel and cobalt compounds proved to be efficient in quenching singlet oxygen mediated photo-oxidative membrane damage of red blood cells. Cadmium compounds showed a pronounced photohemolytic activity and the reaction was oxygen dependent. The deuterium test for singlet oxygen showed a significant increase in photohemolytic efficiency. The addition of histidine, a known quencher of singlet oxygen, resulted in a significant inhibition of the photohemolysis. Pronounced photo-oxidative damage to plasma membranes was also observed in vitro cultivated cells by means of scanning electron microscopy.
Transmission of Bucky (Grenz) rays through human scalp hair
Authors: Wulf HC , Brodthagen H.
Published: July 2023

The shielding effect of various types of human hair and the influence of a shampoo on the transmission of grenz rays were determined by ionization chamber measurements. The mean transmission proved to be 53.7% with clean hair and 48.1% with hair shampooed one week before. P less than 0.05 (n = 50) (Pratt's test). A relationship was found between weight of hair layer and transmission. In clinical practice, the thickness of the hair should be assessed, and the normal skin dose multiplied by 1.5 for patients with a thin hair layer, by 2 in the case of a medium, and by 3 in the case of a thick hair layer.
Scanning electron microscopy of Demodex brevis (folliculorum)
Authors: Pajarre R , Peura R.
Published: July 2023

Abstract is not available
Studies on the influence of antigens on the results with the gonococcal complement fixation test in patients with uncomplicated and complicated gonorrhoea
Authors: Sandström E , Danielsson D.
Published: July 2023

The gonococcal complement fixation test (GCFT) was investigated with regard to its sensitivity and specificity by testing serum specimens from (a) female patients attending a VD out-patient clinic because of suspected gonorrhoea, (b) patients with a proven, uncomplicated, urogenital gonococcal, infection, (c) patients with disseminated gonococcal infection (DGI). Three different pools of gonococcal (GC) antigens were used which were comprised of GC strains from two different geographical areas. It was found that 39% of the females with culture-proven uncomplicated gonorrhoea had a positive GCFT whereas 10% of the females with negative GC cultures had a positive GCFT. The latter were found to have either a history of gonorrhoea or strong clinical suspicion of recent GC infection. One of the GC antigen pools gave a much lower diagnostic yield than the other two pools in the GCFTs with serum specimens from patients with uncomplicated gonorrhoea. However, no differences were found between the antigen pools in the tests with serum specimens from patients with DGI. These findings indicate the presence of various strain antigens participating in the immune response to complicated as well as uncomplicated GC infections. The results are presented in detail and discussed.
Malignant acanthosis nigricans--a para-endocrine syndrome?
Authors: Nordlund JJ.
Published: July 2023

Abstract is not available
Treatment of pityriasis capitis (dandruff) with econazole nitrate
Authors: Aron-Brunetière R , Dompmartin-Pernot D , Drouhet E.
Published: July 2023

63 patients of both sexes with pityriasis sicca or steatoides were examined for presence of Pityrosporum ovale on the scalp. Only those cases in which very numerous yeasts were seen in all squamae present in the preparation were considered positive. According to the severity or duration of pityriasis, 60% of the patients in this population represented severe cases and 38% refractory cases. A solution of econazole nitrate was applied as a spray, morning and evening, for a period of 10 to 20 days (mean). The overall assessment of the clinical effects of econazole nitrate indicated 56 favourable results, with complete disappearance of objective clinical signs in 47 cases; the course of pruritus proceeded roughly parallel with that of the objective signs. The mycological checking of the clinical results, performed at least 7 days after the conclusion of therapy, disclosed 6 failures and 57 successes. In 17 patients, the microscopic examination of squamae was complemented by culture before and after treatment: in all cases, the culture, positive before econazole nitrate therapy, became negative after treatment, thus confirming the results of direct examination. These data suggest that Pityrosporum ovale plays a pathogenetic part in pityriasis simplex capitis.
Lymphogranuloma venereum with hepatic involvement
Authors: Bjerke JR , Hovding Jr G
Published: July 2023

Abstract is not available
Sister chromatid exchanges in lymphocytes from psoriasis patients treated with 8-methoxypsoralen and longwave ultraviolet light
Authors: Lambert B , Morad M , Bredberg A , Swanbeck G , Thyresson-Hök M
Published: July 2023

The frequency of sister chromatid exchanges (SCE) was analysed in peripheral lymphocytes from patients receiving 8-methoxypsoralen (8-MOP) and longwave ultraviolet light (UVA) against psoriasis. The average SCE frequency in 14 patients after 3-10 weeks of clinical treatment did not differ statistically from that before treatment. UVA irradiation in vitro of blood from patients receiving 8-MOP caused a significant increase in the number of SCE. Such an increase was not observed after systemic administration of 8-MOP excluding UVA irradiation in vitro, nor after UVA irradiation in vitro in the absence of 8-MOP. Thus, the combination of oral 8-MOP administration and subsequent UVA irradiation in vitro promotes SCE in peripheral lymphocytes. However, this effect is not seen after clinical irradiation to the skin in vivo. The reason for this may be that the accumulated dose of UVA light in circulating lymphocytes, even after several weeks of clinical therapy, is not large enough to produce a significant amount of DNA damage leading to SCE, or else that DNA damage caused by the treatment is efficiency repaired during the intervals between treatments.
Studies on guinea pig skin cell cultures VII Statistical analysis of growth and maturation
Authors: Delescluse C , Cordier S , Frey J , Regnier M , Prunieras M
Published: July 2023

Thymidine uptake; incorporation of amino acids into perchloric acid extract and HCl extract (corresponding grossly to poorly and highly organized proteins respectively); cell fraction DNA and cell fraction protein contents have all been measured daily from day 1 to day 8 in primary cultures of epidermal keratinocytes (EK) and dermal fibroblasts (DF). Correlations between these five biochemical parameters (or variables) have been sought when using the statistical method of principal component analysis. The analysis of whole data of EK and DF populations taken together revealed that DNA content is a major distinguishing factor between these two cell types. The analysis of variables of each cell type taken independently showed that DF are essentially characterizable by their tendency to synthesize both poorly and highly organized proteins, whereas EK are more prone to DNA and highly organized protein synthesis. Thus, EK and DF in culture can be readily distinguished statistically by analysing their growth and maturation characteristics. It is even likely that time study of thymidine and amino acid incorporation would suffice to characterize these two cell types in vitro.
Third generation infantile syphilis--an unusual presentation
Authors: Singh R , Sharma RC , Baruah MC
Published: July 2023

A case of third generation early congenital syphilis with unusual features is reported and discussed. The infant presented with Livedo reticularis and an ulcer on the right forearm since birth; the underlying radius and ulna showed osteomyelitic changes with sequestrum formation and a pathological fracture. The rest of the skeletal system was normal. The blood STS (VDRL) was reactive at 1:64. The child showed no other evidence of congenital syphilis. Livedo reticularis and bony lesions resolved promptly with penicillin therapy, but abnormal movements at the wrist joint persisted. The mother had pathognomic Hutchinsonian incisors and a reactive VDRL test.
Oral injury caused by fellatio
Authors: Worsaae N , Wanscher B
Published: July 2023

A 34-year-old Caucasian woman is presented with a circular hemorrhagic lesion located on the soft palate and caused by fellatio. The lesion consisted of erythema, petechiae, dilated blood vessels and vesicles. It healed in a few days. No evidence of the major clinical alternatives such as thrombocytopenia, venereal disease, candida infection or pathomimia were found. Injuries due to fellatio must be considered as an etiological factor to hemorrhagic changes of the oral mucosa, and with a positive history, patients can be spared from other investigations.
Melanocyte mitosis in UVB-irradiated mouse skin
Authors: Rosdahl IK
Published: July 2023

Little is known about the mitotic activity of the epidermal melanocyte population. Vincristine sulphate has now been used in vivo to study the frequency of mitosis of epedermal melanocytes in the ear skin of C57BL mice. It is shown that there is continuous formation of new melanocytes in unstimulated skin due to mitosis of pigment-producing epidermal melanocytes. The increase in this mitotic rate following daily UVB irradiation suggests that this is a major mechanism responsible for the UV-induced increase in the epidermal melanocyte population.
Ultrastructure of giant pigment granules in lentigo simplex
Authors: Hirone T , Eryu Y
Published: July 2023

Electron microscopic observation of lentigo simplex on the sole revealed the presence in the lesion of giant pigment granules in melanocytes and keratinocytes. The giant granules were membrane-bound bodies containing electron-dense amorphous substances and less electron-dense microvesicles. It was also revealed that compound melanosomes, similar in size and shape to giant pigment granules, were present in melanocytes. Within the compound melanosomes, melanosomes showed disintergration into electron-dense fine particles concomitant with the release of less electron-dense microvesicles. These fine particles then aggregated to the mass of electrondense amorphous substances which eventually embedded the microvesicles. This evidence strongly suggests that the giant pigment granules are formed by complete degradation of melanosomes in the large compound melanosomes which can arise within melanocytes by autophagy.
Generalized pustular toxic erythema: pathogenetic relationship between pustule and epidermal appendage (hair follicle or sweat duct)
Authors: Ogino A , Tagami H , Takahashi C , Higuchi T
Published: July 2023

Seven patients are described, who had generalized toxic erythema with sterile pustules. Study of serial sections of the pustules confirmed a specific localization to hair follicle or epidermal sweat duct. Five patients had a past history of medications, exposure to an organic solvent, or infections.
The constituents of keratohyalin granules of newborn rat epidermis under an electron microscopy
Authors: Tezuka T , Hirai R
Published: July 2023

Three-day-old rat skins were treated either by the freezing--thawing method or by the tetraphenylboron technique. After the former procedure, keratohyalin granules were solubilized, leaving empty spaces with an electron-dense or less dense rim. Particles roughly 200 A in diameter, which were either electron-dense or less dense, were observed in the empty spaces and also seen detaching from the rim. After the freeze--thaw procedure, two types of keratohyalin granule were observed. The one is the same electron-dense granule as keratohyalin granules in vivo and the other is the granule, the electron density of which was identical with tonofilaments. Both granules were granular rather than fibrous in structure.
Sensitization capacity of epoxy reactive diluents in the guinea pig
Authors: Thorgeirsson A
Published: July 2023

The sensitization capacity of six epoxy reactive diluents was investigated with the "guinea pig maximization test". All the low molecular weight reactive diluents (MW 175 to 360) proved to be sensitizers. One diluent of higher molecular weight (MW 1700) produced no reaction.
Food allergy in atopic dermatitis: experimental observations
Authors: Bonifazi E , Garofalo L , Monterisi A , Meneghini CL
Published: July 2023

Results of an investigation of 134 subjects with atopic dermatitis and 29 controls are described. The investigation involved: 1) an allergological enquiry into each patient's medical history, with particular reference to consumption of eggs, milk and fish; 2) a total IgE assay; 3) RAST with egg, milk, cod; 4) a challenge test. Recording of medical histories revealed the existence of clinical sensitivity to egg, milk and cod in respectively 21, 17 and 7 of the 134 subjects with atopic dermatitis, but in none of the controls. In the atopic subjects, RAST demonstrated egg, milk and cod antibodies in 37, 28 and 14 cases respectively, while of the controls only 2 had antibodies--and then in minimal amounts. The maximum incidence of egg and milk antibodies was demonstrated in the initial 3 years of life. Clinical sensitization to cod manifests itself in the form of attacks (urticaria, angi-oedema, vomiting) showing significant correlation between clinical history, results of RAST and the response to challenge, while in the case of sensitivity to eggs and, even less evidently, to milk, the symptoms are more often referred to as "exacerbation of the dermatosis" and the results of RAST, of challenging and the clinical history tend to be contradictory.
Acne-like eruptions induced by PUVA-treatment
Authors: Nielsen EB , Thormann J
Published: July 2023

Photochemotherapy with psoralen and long-wave ultraviolet light, so-called PUVA-treatment, is currently being evaluated in many dermatologic departments. Side effects such as nausea, pruritus and erythema are well known. Recently the development of acneiform eruptions was reported in a British patient treated with PUVA (3). We found that 4 out of 80 patients treated in our clinic with 8-methoxy-psoralen according to the usual weight schedule (6) and long-wave ultraviolet irradiation developed perioral dermatitis, in 2 cases, together with acneiform eruptions localised to the forehead.
Intermittent treatment of psoriasis with clobetasol propionate
Authors: Hradil E , Lindström C , Möller H
Published: July 2023

Clobetasol propionate cream, applied intermittently for 2 weeks, induced a rapid clinical and histological clearing of psoriatic infiltrates. The serum cortisol level was transiently lowered. By maintenance therapy, with the corticosteroid given only one day a week, 8 of 12 patients were kept in remission for an average period of 5 months.
Acne treatment with oral zinc and vitamin A: effects on the serum levels of zinc and retinol binding protein (RBP)
Authors: Vahlquist A , Michaëlsson G , Juhlin L
Published: July 2023

The serum levels of zinc, vitamin A and retinol binding protein (RBP) were studied in 75 acne patients before and during oral treatment with zinc, vitamin A or placebo. In the zinc-treated patients an increase in the mean serum zinc level was seen after 2 weeks, when also the first clinical improvement occurred. After 4 weeks the zinc level had increased by about 30% and no further significant increase was observed during 3 months of treatment. In 33 healthy subjects there was an increase of 14% after 4 weeks of zinc therapy. Vitamin A and placebo induced no significant changes in the serum zinc status. Prior to therapy the serum levels of vitamin A and RBP were lower in the acne patients than in the controls. Zinc + vitamin A treatment raised the serum RBP value to normal after 4 weeks. In patients given vitamin A alone, a probable increase in RBP was achieved. Zinc and placebo treatment did not change the serum level of RBP.
Treatment of acne with cyproterone acetate and ethinyl estradiol
Authors: Palatsi R , Ylöstalo P , Taipale A
Published: July 2023

Tablets containing 2 mg cyproterone acetate and 0.05 mg ethinyl estradiol in a calendar package of 21 days were used as an oral contraceptive to treat acne. The series comprised 20 patients. The women were 18--43 years of age, and all had acne which had previously been resistant to therapy. The treatment was continued for 6 months. Serum testosterone, 17-OHCS, 17-KS, serum ALAT and gamma-GT were recorded prior to the treatment at 3 and 6 months. Ten patients responded well to the treatment, 5 responded moderately well, 3 experienced no change, and 2 became worse. The serum testosterone level fell during the therapy and the ALAT level rose, though only one pathological ALAT value was recorded.
A clinical and histological study of cutaneous leishmaniasis
Authors: Nicolis GD , Tosca AD , Stratigos JD , Capetanakis JA
Published: July 2023

Sixty-five cases of proved cutaneous Leishmaniasis have been studied on clinical, histological and laboratory grounds. A new histological classification is proposed and emphasis is given to specific histological changes and their correspondence to distinct clinical signs.
The painful, non-indurated chancre
Authors: Andersen KE
Published: July 2023

After reviewing 20 consecutive male patients with primary syphilis and 23 textbooks on venereology, it can be emphasized that the syphilitic chancre may be painful, and not indurated, and that the textbooks in some cases give a misleading description of the disorder.
Abnormal skin collagen in scleroderma
Authors: Blumenkrantz N , Asboe-Hansen G
Published: July 2023

A significant decrease in the content of hydroxyproline and hydroxylysine was found in the skin of patients with generalized scleroderma (acrosclerosis), the lowering of Hyp being more marked than that of Hyl. The production of an abnormal collagen or a change from one collagen type to another is suggested to take place.
Chronic hypertrophic vulvitis--a condition with similarities to cheilitis granulomatosa (Melkersson-Rosenthal syndrome)
Authors: Larsson E , Westermark P
Published: July 2023

Abstract is not available
Diisopropylfluorophosphate-evoked inhibition of anaphylactic histamine release from human skin: decrease of the inhibition by storing the skin specimens
Authors: Yamamoto S , Greaves MW.
Published: July 2023

Antigen-induced histamine release from human skin slices passively sensitized with reaginic serum in vitro was inhibited by DFP, suggesting involvement of serine esterase activation in the reaction. The magnitude of DFP-evoked inhibition of the histamine release was not the same in each skin sample and no correlationship was observed between the magnitude of the DFP-evoked inhibition of the histamine release and that of the histamine release in the absence of DFP. The magnitude of the histamine release in the presence of DFP was smaller in the fresh skin than in the stored skin, whereas that in the absence of DFP was greater in the former than in the latter. The inhibitory effect of cytochalasin B on the anaphylactic histamine release from fresh and stored human skin was the reverse of the effect of DFP. The present results indicate that the magnitude of anaphylactic histamine release from human skin does not match that of the activation of serine esterase in the reaction, suggesting the possibility that there may be some factor modulating the activation of serine esterase in the anaphylactic reaction in human skin.
Occurrence of immunoglobulins and complement in the skin of patients undergoing topical treatment of mycosis fungoides
Authors: Volden G , Husby G.
Published: July 2023

Deposits of immunoglobulins (IgG, IgA and IgM) and complement were occasionally found in lesional skin of mycosis fungoides patients. However, after complete remission of the skin lesions, deposits of immunoglobulins and complement were found, corresponding to previous infiltrates or tumours, in about half of the patients. These deposits appeared as globular bodies in the upper part of the dermis closely connected with the basement membrane.
'Rusters'. The corrosive action of palmar sweat: I. Sodium chloride in sweat
Authors: Jensen O.
Published: July 2023

Sweat from 8 'rusters' and 8 control persons was examined for its sodium concentration. Sweating was induced by iontophoresis of pilocarpine on the distal forearm. In no case did the concentrations exceed the normal upper limit for this procedure, and no difference was found between the two groups. In this way the study failed to confirm earlier reports of elevated sodium chloride concentrations in sweat from 'rusters'. Proposals of a relationship between 'rusters' and patients with pancreatic cystic fibrosis were not substantiated. Hyperhidrosis of the palms and volar surfaces of the fingers was present in all 'rusters'. This seemed to be the main cause of the corrosive tendency, and patients referred for palmar hyperhidrosis were found to produce corrosion similar to the 'rusters'. Topical application of aluminium chloride hexahydrate in a 25% solution in absolute ethyl alcohol proved effective against both hyperhidrosis and the corrosive tendency.
Mucinosis follicularis provoked by light exposure
Authors: Lagerholm B , Wennersten G.
Published: July 2023

The present paper reports a study on a case of follicular mucinosis exacerbated by sunlight exposure. Provocation with standardized light testing was carried out on both normally pigmented skin and on areas of hypopigmentation representing a residual state after earlier skin lesions but without any signs of active mucinosis follicularis. Typical clinical and histologically verified lesions were provoked by the light test procedure, best seen in hypopigmented areas but with similar changes in normally pigmented skin. Characteristic findings developed gradually, assuming an appearance identical with that of the observed spontaneously elicited lesions after 3--4 weeks. Treatment with carotenoids periodically over several years has provided a proper light protective effect, as only minimal lesions have been noted during these periods, compared with extensive changes during similar periods without treatment.
Abnormal glucose tolerance associated with lichen planus
Authors: Halevy S , Feuerman EJ.
Published: July 2023

A study was made of 52 patients with lichen planus. Abnormal oral glucose tolerance was found in 19 (36%), including 5 with overt diabetes. The criteria for abnormality were based on an age-related score method. A family history of diabetes was found to be present in 14 (26%). The most common abnormality observed in the glucose tolerance test was an elevation of the blood glucose level 2 hours after administration of the glucose. These results further support the supposition of a disorder in carbohydrate metabolism associated with lichen planus.
Studies on Fc-receptor-bearing mononuclear leukocytes from peripheral blood of patients with dermatitis herpetiformis
Authors: Thorsteinsson L , Braathen LR , Frøland SS.
Published: July 2023

Isopaque-Ficoll separated mononuclear cell suspensions from peripheral blood of patients with dermatitis herpetiformis (DH) and healthy controls were investigated by means of a rosette assay for Fc-receptor-bearing leukocytes (EA-RFC), peroxidase staining for monocytes (Pox) and a plaque formation assay (PFC) as well as a 51Cr release assay for cell-mediated cytotoxicity. The cell suspensions were investigated both before and after fractionation on nylon fibre columns. In the patients the mean percentage of PFC in unfractionated cell suspensions was significantly higher than in the controls. In fractionated cell suspensions both the mean percentage of EA-RFC and the mean cytotoxicity index in the 51Cr release assay were significantly lower than in the controls. There were no differences in the percentages of PFC- and Pox-positive cells in fractionated cell suspensions. The results suggest a numerical defect of circulating Fc-receptor-bearing lymphocytes as estimated both by the rosette assay and the 51Cr release assay. These data may reflect a pathogenetic role of these lymphocytes in DH.
Chronic non-scarring folliculitis of the scalp
Authors: Hersle K , Mobacken H , Möller A.
Published: July 2023

Forty patients with recurrent follicular pustules of the scalp but without obvious necrosis or residual scarring were re-examined (mean 8.3 years after onset of lesions). The most common age at onset was 20-40 years. The sex ratio (M/F) was 3 : 1. Only 7 of 40 patients had concomitant acne vulgaris on the face. All patients still had active, recurring scalp lesions, although 7 out of 40 had had temporary remissions. Post-lesional scarring was not observed. Oral low-dose tetracyclines had a symptomatic effect in 7 of 11 patients. Most of the patients treated topically with steroids and alcoholic lotions experienced little or no effect. Histopathology disclosed a neutrophilic folliculitis. Bacteriological examinations showed only the usual resident microflora of the scalp with P. acnes being the most frequent species. In 3 cases (5 examined pustules), P acnes was isolated from the content of the pustules without being found on the skin surface over the pustule. Chronic non-scarring folliculitis of the scalp probably constitutes a disease entity.
Peroral aromatic retinoid treatment of palmoplantar pustulosis: double-blind comparison of Ro 10-9359 and placebo
Authors: Jansén C , Hollmén A , Pajarre R.
Published: July 2023

Nineteen patients with chronic, recalcitrant palmoplantar pustulosis took either placebo or aromatic retinoid ethyl ester (Ro 10-9359) during a 4-month therapeutic trial. The maximal dose of Ro 10-9359 varied between 25 and 100 mg per day, according to the individual patient's tolerance. An excellent or good therapeutic response was obtained in 6 out of 9 patients on the active medication and in 2 out of 10 patients on placebo. The difference in therapeutic response between the Ro 10-9359 group and the placebo group was statistically significant (p less than 0.05). Drying and chapping of the lips was the most common side effect of Ro 10-9359 treatment.
Increased urine histamine after challenge of contact sensitivity in the mouse
Authors: Roupe G , Granerus G.
Published: July 2023

Abstract is not available.
Diffuse fasciitis with eosinophilia: histological and electron microscopic study
Authors: Tamura T , Saito Y , Ishikawa H.
Published: July 2023

A female case of diffuse fasciitis with eosinophilia (or eosinophilic fasciitis) is reported. This disease is characterized by suddenly developed circumscribed subcutaneous indurations on the extremities, hyalinized fibrosis of the fascia and peripheral eosinophilia. Our patient further displayed Raynaud's phenomenon preceded by thrombophlebitis, and histological and electron microscopical features of her subcutaneous hyalinized area centering at the fascia closely resembled those of morphaea.
Amyloidosis of the skin: a comparison between localized and systemic amyloidosis
Authors: Westermark P.
Published: July 2023

Skin biopsies from patients with different forms of localized and systemic amyloidoses were studied. Subepidermal deposits, typical of lichen amyloidosus, were also seen in other types of amyloidosis, least frequent in the secondary systemic form. Amyloid within the epidermis and especially the horny layer as well as pigmented cells close to the deposits were found in all cases of lichen amyloidosus but in no other specimens. Plasma cells, on the other hand, were numerous in nodular amyloidosis but were not found in any other cases. It is concluded that in the pathogenesis of lichen amyloidosus the epidermis and perhaps dermal melanocytes are involved. In the pathogenesis of localized nocular amyloidosis the plasma cells might be of importance.
Kwashiorkor-like zinc deficiency syndrome in anorexia nervosa
Authors: Esca SA , Brenner W , Mach K , Gschnait F.
Published: July 2023

This report deals with a 26-year-old white woman exhibiting signs of both Kwashiorkor (marasmus, pallor, hypopigmentation of hair and hepatomegaly) and acrodermatitis enteropathica (eczematous dermatitis predominantly on acral areas). Clinical and laboratory examinations excluded malabsorption syndrome and glucagonoma syndrome and revealed hypoproteinemia and marked zinc deficiency. Psychiatric examination disclosed anorexia nervosa. Substitution therapy led to rapid clearing of the skin lesions.
Oral methoxsalen photochemotherapy of uncommon photodermatoses
Authors: Morison WL , White HA , Gonzalez E , Parrish JA , Fitzpatrick TB.
Published: July 2023

Three uncommon idiopathic photodermatoses, refractory to other treatment, responded to oral psoralen photochemotherapy. Tow females with photosensitivity in association with atopy, one female with persistent light reaction following a systemic drug-induced photosensitivity and an elderly male with actinic reticuloid were treated.
Transfer factor in mycosis fungoides: a case report on a patient "cured"
Authors: Zachariae H , Grunnet E , Thestrup-Pedersen K.
Published: July 2023

Abstract is not available.
Lipid droplets of the sebaceous gland: some new observations from tannic acid fixation
Authors: Niizuma K.
Published: July 2023

Abstract is not available.
Effect of chloroquine on DNA synthesis in the skin of DLE patients
Authors: Horkay I , Nagy E , Varga L , Krajczár J , Alföldi G.
Published: July 2023

Changes in the semiconservative and excision repair DNA synthesis were studied autoradiographically in the skin of 12 patients with discoid lupus erythematosus during Chloroquine treatment (500 mg/day for 8 weeks). The originally increased rate of the semiconservative DNA synthesis in the area of the skin lesions returned to the normal level simultaneous with clinical improvement. No effect on the excision reapir DNA synthesis could be detected.
Linear dermo-epidermal IgA deposition in bullous pemphigoid
Authors: Van Joost T , Faber WR , Westerhof W , De Mari F.
Published: July 2023

A case is reported of a patient with a bullous eruption with in vivo linear deposition of IgA and complement (C3) along the basement membrane zone of perilesional skin (DIF method). Some data presented here are in favour of the concept that cases of linear in vivo deposition of IgA alone, or in combination with other IF findings, might be classified as bullous pemphigoid (BP). Clearing of the lesions due to oral prednisone therapy was accompanied by disappearance of complement deposition, while IgA deposition remained unchanged. Some aspects of tissue injury in this case are briefly discussed.
Pruritus in polycythemia vera: treatment with aspirin and possibility of platelet involvement
Authors: Fjellner B , Hägermark Ö.
Published: July 2023

The characteristic temperature-dependent pruritus in polycythemia vera (PV) is described. The triggering factor seems to be a sudden decrease in skin temperature, e.g. after a hot bath or shower. The sudden onset and limited duration of the pruritus might suggest an activation or release of some humoral factor(s). In a controlled study we showed that aspirin alleviates this particular pruritus. Therefore, the possibility of prostaglandin and platelet involvement was considered. It was found that substances such as PGE2 and serotonin, produced and released by platelets, could elicit pruritus in healthy volunteers when injected intradermally and that PGE2 enhanced the cutaneous responses to serotonin. Studies of platelet aggregation did not reveal any abnormalitites in the PV patients but ADP was shown to sensitize platelets to adrenaline-induced aggregation in vitro. Although not proven the following hypothesis is suggested: a combination of ADP, emerging from erythrocytes, and catecholamines released from adrenergic vasoconstrictor nerves when the skin is cooled down, might stimulate platelets to aggregation in skin vessels and to production and release of pruritogenic factors.
The activity in vitro of five different antimycotics against Pityrosporum orbiculare
Authors: Faergemann J , Bernander S.
Published: July 2023

The activity in vitro of miconazole, clotrimazole, econazole, sodium omadine, and sodium thiosulphate against Pityrosporum orbiculare was found to correlate with the good clinical results these drugs produce in tinea versicolor. In addition many substances used as solvents or in vehicles had an inhibitory effect in vitro against P. orbiculare. The influence of the culture medium, especially lipids, on the action of imidazole derivatives is discussed.
Dermatomyositis induced by penicillamine
Authors: Simpson NB , Golding JR.
Published: July 2023

A case of dermatomyositis is reported in a 50-year-old woman receiving D-Penicillamine therapy for rheumatoid arthritis. There was no evidence of neoplasia on full investigation. Remission of dermatomyositis occurred on withdrawal of D-Penicillamine.
Treatment of leishmaniasis recidivens with intralesional injections of emetine hydrochloride: a case report
Authors: Cohen HA , Wahaba A.
Published: July 2023

A patient, suffering for 42 years from the late tuberculoid-type of leishmaniasis located in his face, was successfully treated with intralesional injections of emetine hydrochloride. Previous treatments, which included intralesional injections of steroids and concomitant intramuscular injections of antimonials, flagyl, fluorocytosine, infusions of amphotericin B--with and without concomitant treatment by steroids systemically and/or intralesionally--and amphotericin B intralesionally, were altogether ineffective. In addition, the patient underwent five operations in a plastic surgery department.
Mycosis fungoides plaque stage treated with topical nitrogen mustard with and without attempts at tolerance induction: report from the Scandinavian mycosis fungoides study group
Authors: Molin L , Thomsen K , Volden G.
Published: July 2023

The Scandinavian Mycosis Fungoides Study Group has treated 21 patients with mycosis fungoides in plaque stages with topical, whole-body application of nitrogen mustard, 20 mg in 40 ml water per square metre. Ten patients were treated after previous attempts at intravenous tolerance induction ad modum van Scott & Kalmanson and eleven without. Complete remission was initially achieved in 10 patients and partial remission in 9 patients. Contact dermatitis to nitrogen mustard developed in 2/10 after tolerance induction and in 1/11 without tolerance induction. It is concluded that topical, whole-body application of nitrogen mustard gives high remission rates. In this series, however, many relapses occurred, due to inadequacy of the maintenance treatment. Tolerance induction has not been found of any value.
Graft-vs-host reaction in skin: histological immunological and ultrastructural studies
Authors: Claudy AL , Schmitt D , Freycon F.
Published: July 2023

A case of graft-vs-host reaction after bone marrow transplantation is described. Histopathologic and ultrastructural findings in involved skin showed necrotic keratinocytes and abnormal melanocytes with satellite lymphocytes. No deposits of immunoglobulins or complement were found. These data provide direct evidence that chronic graft-vs-host disease in humans may be related to cellular hypersensitivity rather than to serum factors.
HLA antigens in localized granuloma annulare
Authors: Mobacken H , Lindholm A , Sandberg L.
Published: July 2023

HLA antigen frequencies were studied in 46 patients with localized granuloma annulare. The results do not support the hypothesis of an association between this condition and insulin-dependent diabetes mellitus.
The usefulness of the nonspecific skin hyperreactivity (the pathergy test) in Behçet's disease in Turkey
Authors: Tüzün Y , Yazici H , Pazarli H , Yalçin B , Yurdakul S , Müftüoğlu A.
Published: July 2023

49 of 58 (84%) patients with Beh√ßet's disease in Turkey had a positive pathergy test; the same test proved positive in 3 of the 90 (3%) of healthy and diseased contols.
Mycosis fungoides with verrucous lesions
Authors: Nicolis GD , Stratigos JD , Tosca AD , Capetanakis JA.
Published: July 2023

Abstract is not available.
Prednimustine in mycosis fungoides: a report from the Scandinavian mycosis fungoides study group
Authors: Molin L , Thomsen K , Volden G , Bergqvist-Karlsson A , Hellbe L.
Published: July 2023

Abstract is not available.
Chromonychia following thermal injury
Authors: Jeune R , Ortonne JP.
Published: July 2023

Abstract is not available.
Argon laser induced cutaneous sensory and pain thresholds in post-herpetic neuralgia. Quantitative modulation by topical capsaicin.
Authors: Bjerring P , Arendt-Nielsen L , Søderberg U
Published: July 2023

Sensory and pain thresholds to cutaneous argon laser stimulation were determined in patients with post-herpetic neuralgia before and during treatment with topical capsaicin. Before treatment both thresholds were significantly elevated on the affected side compared to the contralateral normal area. After one week of capsaicin treatment both thresholds were significantly increased compared to the pre-treatment values, and the subjective pain relief, measured on a visual analogue scale (VAS) was 24%. More than 10% decrease in VAS pain score was obtained by 62.5% of the patients. Laser stimulations at levels at which the sensory and pain thresholds are reached were initially described as burning or stinging with pain projecting outside the stimulated area. This allodynia to laser stimulations changed during capsaicin treatment towards normal sensory and pain perception qualities. Both sensory and pain thresholds and the subjective pain score evaluated on a visual analogue scale were attenuated during the capsaicin treatment, suggesting a significant role of the cutaneous sensory and pain receptors in postherpetic neuralgia.
Physiological skin surface water loss dynamics of human vulvar and forearm skin.
Authors: Elsner P , Wilhelm D , Maibach H I
Published: July 2023

In order to estimate the influence of occlusion and sweating on forearm and vulvar skin surface water loss (SSWL), both were measured simultaneously and continuously for 30 min in 8 healthy women. Vulvar SSWL decreased significantly during the measuring period from 24.9 +/- 5.2 gm-2 h-1 (mean +/- standard error of the mean) in the first 5 min, to 13.4 +/- 1.7 gm-2 h-1 in the last 5 min (p less than 0.05), whereas no significant changes were observed in forearm SSWL. The vulvar SSWL decay curve followed a logarithmic equation of the form y = a*tb. Irregular SSWL increases ('bursts') were observed in vulvar (but not in forearm) skin of 7 out of 8 women. These SSWL bursts were considered to be caused by sweating. The study shows possible causes of systematic errors in vulvar irritation studies. Methods for error reduction are discussed.
Elastase-inhibiting activity in scaling skin disorders.
Authors: Chang A , Schalkwijk J , Happle R , Van de Kerkhof P C
Published: July 2023

Elastase inhibiting activity (EIA) has been observed in normal skin as a response to surface trauma, immediately following the intra-epidermal accumulation of polymorphonuclear leukocytes (PMN). In order to elucidate the relation between EIA and inflammation, the inhibiting activity was assessed in skin samples of scaling dermatoses (a) without significant inflammation: erythrodermic autosomal recessive lamellar ichthyosis (EARLI), non-erythrodermic autosomal recessive lamellar ichthyosis (NEARLI), X-linked recessive ichthyosis (XLRI) and X-linked dominant chondrodysplasia punctata (XLD-CDP); (b) with predominantly mononuclear cell infiltration: atopic dermatitis; (c) with mixed infiltration of PMN and mononuclear cells: psoriasis and Netherton syndrome. All skin disorders investigated showed an increased EIA as compared with normal skin. Scales from psoriatic lesions, EARLI and Netherton syndrome showed a statistically significant increase in EIA above that observed in other monogenic disorders of keratinization NEARLI, XLRI XLD-CDP and above atopic dermatitis. EIA proved to be an indicator for abnormal keratinization with a marked expression when a mixed infiltrate is present in the skin.
Recurrent pityriasis rosea. New episodes every year for five years. A case report.
Authors: Halkier-Sørensen L
Published: July 2023

A case of recurrent pityriasis rosea in a 39-year-old woman is presented. She had her first attack of pityriasis rosea 5 years ago and new outbreaks followed every year, in the spring. Her husband had a severe attack of pityriasis rosea 6 years ago. All laboratory investigations were normal and no explanation for the many recurrences was found.
Cyclosporin A and pityriasis rubra pilaris.
Authors: Ghazi A , Laso-Dosal F
Published: July 2023

No abstract available.