bluuebunny/crossref_metadata_2025 huggingface dataset:
AI Assisted Learning
Authors: Miller Adam L.
Published: December 2023

Both Web 4.0 and EDU 4.0 are malleable terms, that while difficult to define, set the basis for contemporary learning environments. Within these boundaries, AI (Artificial Intelligence) and AIEd (Artificial Intelligence in Education) have further complicated modern pedagogy with an ever-increasing list of potential benefits and pitfalls. This paper argues that to utilize AI and AIEd to its fullest potential, it must first be understood before it is implemented, and that while the increased presence of AI in our daily lives may be inevitable, the path it follows is not predetermined. This paper briefly explores the history of AI and AIEd technology and assesses not only the potential benefits of AIEd and how they may be fully realized, but also three areas of concern; privacy and data use, inherent bias, and the role of the educator in the future. Through flexible, cyclical models and careful consideration, this paper argues that AIEd will not automatically lead to a phasing out of teachers in learning environments, but, if due care is made, the potential benefits of AI technology can be forged in a way that they improve the working and learning experiences for all stakeholders.
Riding against patriarchy
Authors: ANKYIAH FRANCIS
Published: December 2023

Equestrian portraiture has historically upheld gender norms by depicting powerful men and excluding women artists. 17th and 18th-century equestrian portraits of women depicted them as passive objects, often overshadowed by their male counterparts. These portraits reinforced traditional gender roles and upheld the patriarchal hierarchy prevalent during that time. This paper examines how Ghanaian contemporary artist Sarfowaa challenges patriarchal traditions through feminist self-portraiture in appropriated historical equestrian paintings. Through visual analysis of composition, techniques, symbols and contextualize selected artworks, this article explores how Sarfowaa subverts the equestrian genre by inserting herself into these male-dominated paintings. Her self-portraits provide a powerful statement of resistance that reclaims authority and agency for women. By contextualizing Sarfowaa's work within feminist art movements and theory, this paper analyzes how her art dismantles traditional gender roles and norms. The results demonstrate that Sarfowaa's portraits further the aims of feminist portraiture through their bold questioning of patriarchal power structures. This research expands current scholarship on the intersections of art, portraiture, feminism, and political resistance. It appeals to academics, artists, and audiences interested in the capacity of contemporary art to drive social change.
Eficiencia de la medicina tradicional para el tratamiento del susto en las comunidades de la zona sur de Puno, 2023
Authors: Calderon-Torres Alfredo , Saavedra-Pinazo Marco A. , Billard-Soriano Robinson L.
Published: December 2023

El susto es una forma de espanto que se presenta en todas las personas, produciendo un desequilibrio emocional. Este fenómeno es adquirido en lugares sagrados y encantados, y en horas crepusculares, que generalmente afecta el desempeño intelectual y la actividad rutinaria de las personas. El propósito de esta investigación fue examinar la eficiencia de la medicina tradicional para el tratamiento del susto en las comunidades de la zona sur de Puno. La investigación es de corte cualitativo-inductivo, del tipo descriptivo-etnográfico; como instrumento se empleó la entrevista a profundidad; para el análisis e interpretación de los hallazgos se hizo uso del software Atlas ti para el análisis. En los resultados se consideró el diagnóstico del susto, realizado con el análisis de la lectura de coca por los yatiris, para determinar el estado del paciente se empleó la radiografía del cuy (cavia porcellus), asociados a síntomas del susto natural y sobrenatural; para las formas de tratamiento, se realizó el procedimiento con la intervención de animales, aves, plantas y minerales. Las practicas rituales son ejecutados por los yatiris, quienes participan con oraciones, uso de ofrendas, prendas de vestir y campanilla pronunciando el nombre del paciente para llamar el ánimo y disminuir el estado psicosocial del enfermo con susto.
Post-operative Dressing for Paediatric Hypospadias Repair
Authors: Kaya Cem , Eryılmaz Sibel , Kapisiz Alparslan , Karabulut Ramazan , Turkyilmaz Zafer , Atan Ali , Sonmez Kaan
Published: December 2023

The optimal dressing is still unclear, despite hypospadias being one of the most prevalent surgical operations. Children’s dressing for hypospadias surgery was searched on PubMed as “dressing for hypospadias,” “postoperative dressing for pediatric hypospadias,” and “dressing AND hypospadias.” Experimental studies, animal studies, reviews, letters, and repetitive publications were excluded from the study. By evaluating these reviewed publications, factors affecting hypospadias dressing, such as surgeon, country, dressing type, characteristics, and why it is preferred, will be revealed. As a result, 17 articles were examined, and the advantages of each were established by examining the results. The type of hypospadias, the surgeon’s choice, and its ease of removal stand out as the crucial factors in treating hypospadias in children, along with the degree of development of the nation.
Pregnancy After Breast Cancer: Is it Safe?
Authors: Antoniou Victoria
Published: December 2023

AN INSIGHTFUL session featuring a debate analysed the safety and feasibility of pregnancy amongst survivors of early breast cancer (EBC) at the European Society for Medical Oncology (EMSO) Annual Congress 2023, held in Madrid, Spain, from 20ᵗʰ–24ᵗʰ October. Chaired by Ann H. Partridge, Dana-Farber Cancer Institute, Boston, Massachusetts, USA, both sides of the argument were covered, before concluding with a vote from the audience, both in person and virtually.
Houses of Terror, Castles of Despair: Nightmarish Necropoetics and Necropolitics in the Victorian Workhouse
Authors: Margaret Davison Carol
Published: December 2023

This essay brings Achille Mbembe’s intellectually trenchant theory of necropower to bear on the early Victorian era’s most despised and iconic institution, known as the workhouse, arguably one of the most preeminent emblems of democracy’s nocturnal body located within Britain. Regarded by many of its critics as enacting the Utilitarian, inhumane, and ‘mechanistic’ treatment of the poor (Crowther, ‘Workhouse’ 194), the workhouse was frequently portrayed using the Gothic mode as a necropolitical institution, a death manufactory that monstrously combined prison, factory, asylum, slaughterhouse, and dead house – some of society’s most dehumanizing, disciplinary, and dreaded locales. Taking posters, illustrations, broadside ballads, penny dreadfuls, and novels as its primary sources – cultural productions with working and lower-middle class readerships for whom the workhouse and the Anatomy Act posed the greatest threat – this essay examines the workhouse through socio-political, economic, and theological lenses, and relevant scholarship in the rapidly expanding, interdisciplinary field of Thanatology Studies. It contextualises Workhouse Gothic in relation to Victorian Christian beliefs and attitudes towards death, dying, mourning, and memorialisation, phenomena and concerns that span both sides of the grave, and discusses what was at stake in those cultural narratives in relation to domestic and national values, and the development of working-class identity, subjectivity, and class consciousness.
Clinical features of oncohematological diseases in twins (literature review)
Authors: Radjabova G. A. , Valiev T. T.
Published: December 2023

Relevance. According to the World Health Organization, the most common oncological diseases in childhood are hemoblastoses. In particular, acute leukemia ranks the first in the structure of malignant tumors, non-Hodgkin’s lymphomas – the third, Hodgkin lymphoma – the fifth in children aged 0 to 19 years. There is no convincing evidence of the inheritance of these diseases, but nevertheless, the literature describes cases of the development of the same disease with the same immunophenotype within the same family in mono- or dizygotic twins, which is one of the proofs of the persistence of preleukemic cells and the possibility of their migration from one twin to another during the antenatal development. These data allow us to study the features of oncogenesis in leukemia in twins, in particular monozygotic twins: the timing of tumor development, clinical features and molecular biological characteristics, as well as the response to therapy.

Aim. To study the clinical and molecular-genetic features of hemoblastoses in twins.

Materials and methods. When writing a literature review, we analyzed data in specialized medical databases PubMed, Scopus, Web of Science with the very first descriptions of the manifestations of tumors of the hematopoietic system in monozygotic twins from 1964 to 2023.

Results. In the course of writing this literature review, we confirmed that the genetic component plays a significant role in the development of hemoblastoses. Studies on twins reveal genetic mutations that predispose to the development of malignant blood tumors, which in turn opens up new opportunities for the early diagnosis of hemoblastoses. The twin method allows for comparative clinical trials of different treatment approaches, which help to choose the optimal therapy and improve the prognosis of diseases.
On the advisability of using a fortified product based on goat milk in the diet of people leading an active lifestyle
Authors: Volkova L. Yu. , Orlova S. V. , Nikitina Е. А. , Batysheva Т. Т.
Published: December 2023

Adequate optimal nutrition creates conditions for maximum physical performance, increases the body’s resistance to stress and the effects of any adverse factors. Various nutritional disorders reduce the effectiveness of training activities and negatively affect the effectiveness of training in people involved in fitness. In order to optimize the diet of this category of people, an instant product made from whole fortified goat milk (New Zealand) can be recommended. This product serves as a source of complete and well-digestible protein, calcium, and vitamin D. Linoleic acid (omega‑3) and micronutrients included in the composition increase tolerance to physical activity and help ensure water balance and muscle contraction. Consumption of a goat’s milk product helps stimulate muscle anabolism and reduce possible muscle damage. The liquid form of the finished product prevents the feeling of heaviness in the stomach, prevents the development of dehydration against the background of intense physical activity, and the composition and form allow it to be recommended after workouts or as a snack.
Review of studies on the effect of non-alcoholic tonic drinks on the health of children and adolescents conducted in the period from 2015 to 2023
Authors: Gorelova Zh. Yu. , Guryanova M. P. , Kurgansky A. M.
Published: December 2023

The article provides information about energy drinks, the composition and properties of substances that make up energy drinks, their effect on the body. Cases of negative impact on the health of adolescents are described. The analysis of the results of scientific research conducted in Russia and abroad in the period from 2015 to 2023, and presented in domestic and foreign scientific publications, which address a wide range of problems related to the influence of energy tonics on the body: their impact on the health and adaptive potential of young people, the impact of consuming a large number of energy drinks on the parameters electrocardiograms and blood pressure, the effect of energy drinks on the health of medical students, the effect of energy drinks on the concentration of students’ attention, including studies conducted on animals.
α-Lipoic acid as an ingredient of specialized food product and dietary supplement
Authors: Kodentsova V. M. , Risnik D. V.
Published: December 2023

A review of the literature in recent years was carried out using the RSCI, Google Scholar, Pubmed, and ResearchGate databases.

The purpose of the review was to assess the content of α-lipoic acid (ALA) in foods and compare the doses allowed for use in dietary supplements and specialized food products with doses that provide a clinical effect. ALA or thioctic acid is synthesized in the organism and is also found in foods in free oxidized and reduced form, bound to proteins by hydrogen bonds, as well as covalently bound to lysine residues (lipoyl-lysine) in proteins, which complicates the analytical determination and reduces the bioavailability of this vitamin-like substances. Various methods for determining the natural content of individual forms (ALA and lipoyl-lysine) and their total content in food products have been described. The content of free ALA in 100 g of raw products of animal origin varies from 0.22 to 1.35 mg, of plant origin – from 0.22 to 2.04 mg. Losses during heat treatment reach 77–92%. Lipoyl–lysine content ranged from 2.11–3.99 µg/g heart, 0.56–1.17 µg/g liver, 0.71–1.40 µg/g kidney, while ALA amounts ranged from 0.22 up to 0.55 µg/g heart, from 0.38 to 0.51 µg/g liver. It is difficult to estimate the dietary intake of the total amount of all forms of ALA due to differences in extraction and detection methods. According to the domestic regulatory framework, the adequate level of ALA consumption for adults is 30 mg/day, the upper permissible level of daily consumption for adults as part of specialized food products (SFP), preventive and therapeutic nutrition and dietary supplements is 100 mg/day. ALA is often included in multicomponent dietary supplements and SPP in doses from 15 mg to 100 mg. A positive effect when taken for 10 or more weeks on lipid and carbohydrate metabolism, as well as other clinical effects in patients, is observed when taking ≥ 600 mg of ALA per day, which is significantly higher than the doses allowed for inclusion in the SFP.
Perangkat Lunak Berbasis Mobile Untuk Jasa Cetak Online
Authors: Fadelis Sukya  , Ellya Nurfarida
Published: December 2023

PRINDEL ( Print and Delivery) adalah sebuah aplikasi yang dibangun dengan fungsi utama menyediakan fitur-fitur pelayanan  jasa cetak dan antar dokumen.  PRINDEL mengambil konsep seperti layaknya aplikasi e-commerce secara umum tetapi PRINDEL berjalan dengan platform mobile, sehingga disebut sebagai m-commerce. M-commerce PRINDEL dijalankan pada aplikasi mobile untuk smartphone andoid. PRINDEL memiliki 2 pengguna yaitu admin toko dan customer. Admin dapat melakukan kegiatan registrasi toko, sign in, melihat daftar  order print, melihat alamat delivery serta mellihat dan edit profil percetakan. Sedangkan customer dapat melakukan kegiatan registrasi customer, sign in, edit profil, tambah order, tambah file, tambah lokasi delivery dan melihat summary order. PRINDEL merupakan sebuah aplikasi personalisasi m-commerce dimana customer dapat melakukan pemesanan sesuai dengan keinginan pengguna. Aplikasi PRINDEL akan memiliki hak akses untuk melihat lokasi dari customer dan melihat media penyimpanan data jika customer mengijinkan.
Metode AHP dan Analisis Asosiasi Untuk Menentukan Startling Line-Up Pemain Sepakbola
Authors: Andika Kurnia Adi Pradana  , Retantyo Wardoyo
Published: December 2023

Seorang pelatih klub sepakbola dalam menentukan starting line-up pemain yang sesuai dengan kondisi dan kemampuan pemain serta formasi yang telah ditetapkan memerlukan suatu sistem pendukung keputusan untuk membantunya dalam pengambilan keputusan dengan lebih cepat, cermat dan menghindari subyektivitas keputusan yang dihasilkan. Untuk itu dibangun suatu sistem pendukung keputusan yang bertujuan membantu pekerjaan pelatih klub sepakbola dalam memutuskan pemain-pemain yang berhak masuk dalam starting line-up melalui proses seleski menggunakan Model AHP dan analisis asosiasi. Model AHP mempunyai kemampuan untuk memecahkan masalah multikriteria yang berdasarkan perbandingan preferensi dari setiap elemen pada hirarki. Dari model AHP ini akan dihasilkan peringkat pemain untuk setiap posisi. Analisis asosiasi merupakan suatu metode uyntuk menemukan aturan asosiatif antara suatu kombinasi item. Di dalam aturan asosiatif akan didapatkan pasangan pemain dari pemain-pemain yang menempati posisi tertinggi di peringkat pemain. Penentuan starting line-up ini menggunakan kombinasi antara peringkat pemain dan aturan asosiatif dengan pola pembagian yang seimbang. Dari hasil pengujian menunjukkan sistem ini dapat membantu pekerjaan pelatih dalam memutuskan pemain-pemain yang berhak masuk dalam starting line-up dengan lebih cepat,c ermat dan lebih efektif.
Rancang Bangun Aplikasi Debat Online dalam Rangka Pemilihan Ketua BEM Politeknik Kediri
Authors: Fadelis Sukya
Published: December 2023

Debat adalah kegiatan adu argumentasi antara dua pihak atau lebih, bai k secara perseorangan maupun kelompok, dalam mendiskusikan suatu masalah atau topik. Pelaksanaan debat pada umumnya mengikuti prosedur yang sudah dibuat. Beberapa kendala yang timbul saat pelaksaan yaitu keterbatasan waktu, tempat, peserta, biaya dan adanya resiko emosi yang berlebihan. Dari metode studi lapangan dan pengumpulan data yang dilakukan, dihasilkan sebuah aplikasi debat online yang dapat mengatasi kendala di atas dan membantu kandidat dalam mengkampanyekan dirinya,d an bagi pemilih menjadi lebih mudah dalam memilih kandidat favorit mereka. Aplikasi debat online ini dirancang dengan Bahasa pemrograman PHP dan database MySQL.
Perancangan dan Pembuatan Sistem Informasi Manajemen Aset TI (Studi Kasis di PT. Tiga Serangkai Pustaka Mandiri Surakarta)
Authors: Herwin Zakiyah  , Eva Safitri
Published: December 2023

Asset TI merupakan salah satu sumber daya yang paling penting dalam sebuah perusahaan. Oleh karena itu, pengelolaan asset khususnya asset TI harus diatur secara terstruktur dan sistematis. Tujuan penelitian ini adalah membuat Sistem Informasi Manajemen Aset Tekbologi Informasi yang sesuaidengan kebutuhan PT TSPM. Sistem informasi manajemen asset TI dirancang untuk mengelola asset TI dalam siklus hidupnya, mulai dari inventarisasi asset, maintenance asset, rehabilitasi asset dan penghapusan asset. Dalam sistem yang dikembangkan, siklus hidup asset TI dapat termonitor secara jelas, sehingga dapat mendukung proses pengambilan keputusan bagi pihak manager MIS dan pihak lain yang terkait dengan manajemen asset TI, khususnya dalam hal analisis kebutuhan asset TI, procurement asset TI dan optimalilsasi  aset TI. Metode pengembangan yang digunakan adalah metode SDLC yang terdiri dari beberapa tahapan, meliputi tahap planning, analisis, desain dan implementation. Sistem yang dikembangkan berbasis web dengan dilengkapi fitur Help Desk. Fitur ini berfungsi sebagai media komunikasi dan informasi incident yang dilaporkan oleh user kepada staff TI apabila terjadi permasalahan pada perangkat TI. Dengan demikan, penanganan incident menjadi cepat, ketersediaan aset dapat meningkat dan biaya maintenance relatif lebih rendah.
Perancangan dan Pembuatan Aplikasi Point of Sale Integrasi Barcode
Authors: Heru Prasetyo  , Fadelis Sukya
Published: December 2023

Sistem informasi dalam dunia globalisasi menuntut untuk lebih cepat akurat dan efisien. Terutama didalam dunia bisnis, sebuah sistem informasi sangat diperlukan untuk membantu segala sesuatu termasuk segala proses dan pendataan suatu transaksi yang terjadi. Perancangan dan Pembuatan Aplikasi Point of Sale Integrasi Barcode (Studi Kasus Apotek) secara komputerisasi mencangkup pendataan obat serta transaksi pembelian dan penjualan obat yang berjalan agar lebih mudah, efektif dan efisien
Perancangan dan Pembuatan Aplikasi Kelas Virtual
Authors: Muhammad Muslam  , Fadelis Sukya  , Rudy Arianto
Published: December 2023

Banyak perguruan tinggi masih menggunakan sistem manual dalam pembelajaran dan menggunakan media kertas. Hal tersebut mengakibatkan pencarian data sulit dilakukan dan memerlukan banyak waktu. Oleh karenanya perlu dibangun kelas virtual yang memiliki fasilitas untuk mengelola materi, manajemen tugas dan nilai secara digital. Sistem ini dibangun dengan menggunakan bahasa pemrograman PHP dan menggunakan database mysql. Terdapat beberapa fitur. Antara lain: kegiatan perkuliahan, perekaman data mahasiswa, pengumpulan tugas, dan pemberian nilai tugas. Pada aplikasi kelas virtual ini belum terdapat fitur kuisioner, dan hanya dapat menangani penilaian tugas saja. Saran untuk pengembangan aplikasi yakni dengan membarikan fitur video chating, kuisioner, dan pemberian nilai selain nilai tugas.
Monitoring Pajak Reklame Menggunakan Teknologi QR Code (Quick Response Code)
Authors: Benni Agung Nugroho
Published: December 2023

Banyak perguruan tinggi masih menggunakan sistem manual dalam pembelajaran dan menggunakan media kertas. Hal tersebut mengakibatkan pencarian data sulit dilakukan dan memerlukan banyak waktu. Oleh karenanya perlu dibangun kelas virtual yang memiliki fasilitas untuk mengelola materi, manajemen tugas dan nilai secara digital. Sistem ini dibangun dengan menggunakan bahasa pemrograman PHP dan menggunakan database mysql. Terdapat beberapa fitur. Antara lain: kegiatan perkuliahan, perekaman data mahasiswa, pengumpulan tugas, dan pemberian nilai tugas. Pada aplikasi kelas virtual ini belum terdapat fitur kuisioner, dan hanya dapat menangani penilaian tugas saja. Saran untuk pengembangan aplikasi yakni dengan membarikan fitur video chating, kuisioner, dan pemberian nilai selain nilai tugas.
Aplikasi Penjualan Pulsa Online Menggunakan Payment Gateway
Authors: Yuni Sulistyowati  , Dwi Rahmat Islami
Published: December 2023

Perkembangan teknologi saat ini semakin pesat terutama pada teknologi telepon seluler. Telepon seluler digunakan untuk mempermudah komunikasi jarak jauh dengan pengguna yang mempunyai mobilitas tinggi. Pemenuhan kebutuhan telepon seluler tidak lepas dengan pulsa. Pulsa menjadi kebutuhan primer bagi kalangan masyarakat. Hal ini merupakan peluang bagi penyedia layanan pengisian pulsa. Semakin menjamurnya penyedia layanan pengisian pulsa baik pulsa elektrik maupun pulsa fisik, makin banyak persaingan yang terjadi. Tujuan dari penelitian ini adalah mampu membangun sistem penjualan pulsa secara online untuk mempermudah konsumen saat pembelian pulsa agar konsumen tidak langsung datang ke gerai penjualan pulsa. Dapat Sistem yang akan dibuat mampu merekapitualasi data transaksi penjualan pulsa secara otomatis. Sistem penjualan pulsa di integrasikan menggunakan API Key Veritrans. Dalam laporan simulasi penjualan sampai tahap konfirmasi email.
Cover & Daftar Isi Vol. 15 No. 1 (2023)
Authors: Admin
Published: December 2023

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Analogiövning som stöd för elevers lärande om kemisk beräkning
Authors: Jeppsson Niklas
Published: December 2023

Hanterandet av komplexa frågeställningar inom kemi, såsom kemisk beräkning, kräver en sammansatt förståelse av kemiämnets tre olika kunskapsformer: den makroskopiska, den symboliska och den submikroskopiska. För att bemästra kemiska beräkningar behöver eleverna alltså uppnå större förståelse för abstrakta begrepp som substansmängd men även för hur detta förhåller sig till de symboliska och makroskopiska perspektiven. Ett sätt att stödja lärande av abstrakta fenomen inom naturvetenskap är att använda analogier. I denna artikel presenterar jag en undersökning av huruvida en övning med en partikelanalogi kan stödja eleverna i lärandeprocessen för kemisk beräkning. Resultatet tyder på att analogiövningen gynnade lärandet, och jag diskuterar utifrån detta möjligheten att inkludera den submikroskopiska kunskapsformen inom undervisningen av kemisk beräkning.
Oligomerization and tyrosine nitration enhance the allergenic potential of the birch and grass pollen allergens Bet v 1 and Phl p 5
Authors: Fröhlich-Nowoisky Janine , Bothen Nadine , Backes Anna T. , Weller Michael G. , Pöschl Ulrich
Published: December 2023

Protein modifications such as oligomerization and tyrosine nitration alter the immune response to allergens and may contribute to the increasing prevalence of allergic diseases. In this mini-review, we summarize and discuss relevant findings for the major birch and grass pollen allergens Bet v 1 and Phl p 5 modified with tetranitromethane (laboratory studies), peroxynitrite (physiological processes), and ozone and nitrogen dioxide (environmental conditions). We focus on tyrosine nitration and the formation of protein dimers and higher oligomers via dityrosine cross-linking and the immunological effects studied.
Anti-TLR4 biological response to titanium nitride-coated dental implants: anti-inflammatory response and extracellular matrix synthesis
Authors: Oliva Stefano , Diomede Francesca , Della Rocca Ylenia , Mazzone Antonella , Marconi Guya Diletta , Pizzicannella Jacopo , Trubiani Oriana , Murmura Giovanna
Published: December 2023

Osteointegration is a key process during dental implant placement and is related to titanium surface topography. Implant coating and surface modification methods ameliorate the bone production and the osteogenic process. The current work aimed at evaluating the biological outcomes of two different surfaces of dental implants, machined and titanium nitride (TiN) coated, at an inflammation level using an in vitro model of human periodontal ligament stem cells. The TLR4/MyD88/NF-κB p65/NLRP3 pathway induced by the Porphyromonas gingivalis lipopolysaccharide was studied by means of gene- and protein-level expression. Moreover, the expression of vimentin, vinculin, and fibronectin was evaluated to investigate their effects on the cell adhesion and extracellular matrix deposition. The results of the present study suggest that TiN-coated titanium disks may modulate inflammation by the suppression of the TLR4/MyD88/NF-κB p65/NLRP3 pathway and accelerate extracellular matrix apposition.
Harnessing axonal transport to map reward circuitry: Differing brain-wide projections from medial prefrontal cortical domains
Authors: Bearer Elaine L. , Medina Christopher S. , Uselman Taylor W. , Jacobs Russell E.
Published: December 2023

Graphical Abstract

Tract tracing after MnCl2 stereotactic intracerebral injection is performed by time-lapse MRI in living mice, based on harnessing the intracellular axonal transport machinery, kinesin and microtubules. Volumes of statistically significant, Mn(II)-dependent, image enhancements report on distal accumulations brain wide that can be measured segment-wise for statistical comparisons of the relative strength of the projection contacts. Targets of neuronal projections from the medial prefrontal cortex differ between anterior cingulate (ACA, red) and infralimbic-prelimbic (IL/PL, blue) areas. While neurons in ACA project to central amygdala, posterior hypothalamic regions, periaqueductal gray, dorsal raphe, and locus coeruleus; those in IL/PL project to basolateral amygdala, anterior hypothalamic subsegments, central superior raphe and pons.
Diacetyl strategy for synthesis of NHAc containing glycans: enhancing glycosylation reactivity via diacetyl imide protection
Authors: Fukase Koichi , Manabe Yoshiyuki , Shimoyama Atsushi
Published: December 2023

The presence of NHAc groups in the substrates (both glycosyl donors and acceptors) significantly reduced the reactivity of glycosylation. This decrease was attributed to the NHAc groups forming intermolecular hydrogen bonds by the NHAc groups, thereby reducing molecular mobility. Hence, a diacetyl strategy involving the temporary conversion of NHAc to diacetyl imide (NAc2) was developed for the synthesis of NHAc-containing glycans. This strategy has two significant advantages for oligosaccharide synthesis. The NAc2 protection of NHAc substantially enhances the rate of glycosylation reactions, resulting in improved yields. Moreover, NAc2 can be readily reverted to NHAc by the simple removal of one acetyl group under mild basic conditions, obviating the necessity for treating the polar amino group. We have achieved the efficient synthesis of oligosaccharides containing GlcNHAc and N-glycans containing sialic acid using the diacetyl strategy.
Emotion recognition with multi-modal peripheral physiological signals
Authors: Gohumpu Jennifer , Xue Mengru , Bao Yanchi
Published: December 2023

Introduction

Healthcare wearables allow researchers to develop various system approaches that recognize and understand the human emotional experience. Previous research has indicated that machine learning classifiers, such as Support Vector Machine (SVM), K-Nearest Neighbors (KNN), and Decision Tree (DT), can improve the accuracy of physiological signal analysis and emotion recognition. However, various emotions can have distinct effects on physiological signal alterations. Therefore, solely relying on a single type of physiological signal analysis is insufficient for accurately recognizing and understanding human emotional experiences.

Methods

Research on multi-modal emotion recognition systems (ERS) has commonly gathered physiological signals using expensive devices, which required participants to remain in fixed positions in the lab setting. This limitation restricts the potential for generalizing the ERS technology for peripheral use in daily life. Therefore, considering the convenience of data collection from everyday devices, we propose a multi-modal physiological signals-based ERS based on peripheral signals, utilizing the DEAP database. The physiological signals selected for analysis include photoplethysmography (PPG), galvanic skin response (GSR), and skin temperature (SKT). Signal features were extracted using the “Toolbox for Emotional Feature Extraction from Physiological Signals” (TEAP) library and further analyzed with three classifiers: SVM, KNN, and DT.

Results

The results showed improved accuracy in the proposed system compared to a single-modal ERS application, which also outperformed current DEAP multi-modal ERS applications.

Discussion

This study sheds light on the potential of combining multi-modal peripheral physiological signals in ERS for ubiquitous applications in daily life, conveniently captured using smart devices.
The contribution of a novel PHEX gene mutation to X-linked hypophosphatemic rickets: a case report and an analysis of the gene mutation dosage effect in a rat model
Authors: Chen Xiaoming , Cai Cijing , Lun Shaocong , Ye Qiuli , Pan Weiyuan , Chen Yushi , Wu Yuexuan , Feng Taoshan , Su Faming , Ma Choudi , Luo Jiaxin , Liu Meilian , Ma Guoda
Published: December 2023

A Chinese family was identified to have two patients with rickets, an adult female and a male child (proband), both exhibiting signs related to X-linked hypophosphatemic rickets (XLH). Gene sequencing analysis revealed a deletion of adenine at position 1985 (c.1985delA) in the PHEX-encoding gene. To investigate the relationship between this mutation and the pathogenicity of XLH, as well as analyze the effects of different dosages of PHEX gene mutations on clinical phenotypes, we developed a rat model carrying the PHEX deletion mutation. The CRISPR/Cas9 gene editing technology was employed to construct the rat model with the PHEX gene mutation (c.1985delA). Through reproductive procedures, five genotypes of rats were obtained: female wild type (X/X), female heterozygous (-/X), female homozygous wild type (-/-), male wild type (X/Y), and male hemizygous (-/Y). The rats with different genotypes underwent analysis of growth, serum biochemical parameters, and bone microstructure. The results demonstrated the successful generation of a stable rat model inheriting the PHEX gene mutation. Compared to the wild-type rats, the mutant rats displayed delayed growth, shorter femurs, and significantly reduced bone mass. Among the female rats, the homozygous individuals exhibited the smallest body size, decreased bone mass, shortest femur length, and severe deformities. Moreover, the mutant rats showed significantly lower blood phosphorus concentration, elevated levels of FGF23 and alkaline phosphatase, and increased expression of phosphorus regulators. In conclusion, the XLH rat model with the PHEX gene mutation dosage demonstrated its impact on growth and development, serum biochemical parameters, and femoral morphology.
Factors influencing serum calcium levels and the incidence of hypocalcemia after parathyroidectomy in primary hyperparathyroidism patients
Authors: Mu Yongliang , Zhao Yishen , Zhao Jiannan , Zhao Qi , Zhang Yushuai , Li Yang , Kou Jiedong , Dionigi Gianlorenzo , Bian Xuehai , Sun Hui
Published: December 2023

Background

Parathyroidectomy (PTX) is an effective treatment for primary hyperparathyroidism (PHPT) patients. Postoperative hypocalcemia is a common complication after PTX. This study aimed to analyze the factors influencing serum calcium levels and the incidence of hypocalcemia after parathyroidectomy in primary hyperparathyroidism patients.

Methods

The retrospective study included 270 PHPT patients treated with PTX and collected their demographic and clinical information and their laboratory indices. Factors influencing serum calcium levels and hypocalcemia after PTX in PHPT patients were analyzed using univariate and multifactorial analyses.

Results

First, in patients with normal preoperative serum calcium levels (2.20–2.74 mmol/L), the higher the preoperative alkaline phosphatase and serum phosphorus levels, the lower the postoperative serum calcium levels. Furthermore, the higher the preoperative serum calcium levels and the accompanying clinical symptoms, the higher the postoperative serum calcium levels. Low preoperative serum calcium levels were shown to be a risk factor for postoperative hypocalcemia (OR=0.022), and the optimal preoperative serum calcium threshold was 2.625 mmol/L (sensitivity and specificity were 0.587 and 0.712, respectively). Second, in the mild preoperative hypercalcemia group (2.75-3.00 mmol/L), the older the patient, the higher the preoperative and postoperative serum calcium levels, the higher the postoperative serum calcium; the lower the alkaline phosphatase and calcitonin levels, the higher the postoperative serum calcium levels. On the other hand, the younger the patient was, the more likely hypocalcemia blood was (OR=0.947), with an optimal age threshold of 47.5 years (sensitivity and specificity were 0.543 and 0.754, respectively). Third, in the preoperative moderate to severe hypercalcemia group (>3.0mmol/L), patients undergoing a combined contralateral thyroidectomy and a total thyroidectomy had low postoperative serum calcium levels.

Conclusion

Patients with different preoperative serum calcium levels had various factors influencing their postoperative serum calcium levels and postoperative hypocalcemia, which facilitated the assessment of their prognosis.
Acid base homeostasis and serum bicarbonate concentration in syndrome of inappropriate anti-diuretic hormone secretion (SIADH) with hyponatremia
Authors: Soleimani Manoocher
Published: December 2023

The Syndrome of Inappropriate ADH secretion (SIADH) presents with excess ADH release caused by a range of conditions; including pneumonia, brain tumors, certain lung cancers, and diseases of the hypothalamus. It presents with significant reduction in both sodium and chloride concentrations in the blood. However, reports examining the acid base status indicate a normal serum bicarbonate concentration and systemic acid base homeostasis. The mechanisms for the absence of abnormalities in acid base homeostasis remain speculative. This mini review is highlighting the recent advances in renal molecular physiology to provide answers for the maintenance of acid base status and serum bicarbonate in a physiological range.
The potential of multiapartment rooftop PV systems as citizen’ energy communities in Latvia
Authors: Lebedeva Kristina , Borodinecs Anatolijs , Odineca Tatjana
Published: December 2023

Electricity generation from photovoltaic (PV) in Latvia is currently below the necessary capacity required to contribute to achieving climate neutrality by 2050. However, photovoltaic offer households and companies the opportunity to align their electricity consumption with environmental goals while supporting the European Green Deal objectives. In recent years, there was a growing interest in the installation of photovoltaic microgenerators in Latvia. By June 2023, the total number of households microgenerators connected to the grid has reached 15,000, boasting a collective production capacity exceeding 120 MW. This significant increase is in stark contrast to the situation 5 years ago when Latvia had a mere 3 MW of photovoltaic capacity. Several factors contributed to this growth, including a surge in electricity prices, at times surging more than tenfold, and the implementation of renewable energy (RE) use support measures to facilitate the acquisition of RE systems. Furthermore, 2023 witnessed numerous amendments to Latvia’s energy policy documents and the introduction of the concept of citizen energy communities (CEC), indicating a growing emphasis on harnessing solar energy potential in the country. However, it remains crucial to base these endeavors on accurate, economically viable information regarding solar technologies, their costs and their anticipated long-term outcomes. This manuscript aims to provide an overview of the grid-connected potential of rooftop photovoltaic systems within a Latvian urban setting. Through extensive research, a model has been developed, employing a thoroughly tested simulation program for evaluating the generation capacity of photovoltaic systems. This model considers real electricity consumption data, the existing infrastructure and economic factors. The findings affirm the technical and economic viability of urban rooftop photovoltaic systems within the Latvian context. It has been established that the implementation of such citizen energy communities energy systems holds significant potential. These systems have the potential to be a promising solution for future electricity generation, addressing some of the demands while relieving strain on external power grids. However, the full potential can only be realized with improved infrastructure, and the system’s profitability is heavily contingent on market dynamics and political conditions. This study may also be applicable to other photovoltaic systems facing similar climate conditions.
Understanding the characteristics of agricultural land transition in Thiès region, Senegal: an integrated analysis combining remote sensing and survey data
Authors: Faye Bonoua , Du Guoming , Li QuangFeng , Sané Tidiane , Mbaye Edmée , Zhang Rui
Published: December 2023

Adopting an integrated analysis is a prominent tool for a coherent understanding of the characteristics of agricultural land transition in developing countries. Hence, using an integrated analysis combining remote sensing and survey data, this investigation aimed to understand the spatial-temporal distribution and intensity of agricultural land transition in Senegal through a case study in the Thiès region. Through ArcGIS and ENVI software, we interpreted the land use types from 2000 to 2020 and the transfer matrix method used to characterize the agricultural land transition. Then, the Pearson correlation coefficient is used to determine the intercorrelation between natural and socio-economic driving factors of agricultural land use. The main results show that agricultural land transition was about −588.66 km2. Grassland was the most crucial land morphology to participate in this transition. Regarding spatial distribution, the highest net transition of agricultural land was recorded in Mont-Rolland (33.22%) and the lowest in Sandiara commune (−41.73%). The temporal distribution is represented in Koul, with −0.35%, and Mont-Rolland commune, with 24.84%. The intensity of agricultural land transition was high in Malicounda commune, at 11.34%. The social survey also shows a strong relationship between wind erosion and land salinity (0.971) as potential driving factors that may induce agricultural land transition. Based on an integrated method, the contribution of this study enhances the theoretical approach and methodology for assessing the mean potential driving factors in developing countries such as Senegal. Consequently, agricultural land transition in Thiès region was complex and must be implemented with complex and comprehensible policy solutions.
Replacement of fish oil by alternative n-3 LC-PUFA rich lipid sources in diets for European sea bass (Dicentrarchus labrax)
Authors: Marques Alexandra , Canada Paula , Costa Cátia , Basto Ana , Piloto Fátima , Salgado Maria Antónia , Abreu Helena , Dias Jorge , Valente Luisa M. P.
Published: December 2023

Introduction

In order to ensure lipid quality of cultured fish and an environmentally sustainable production, new alternative sources of EPA and DHA are needed to replace traditional lipid sources, such as fish oil.

Methods

Different combinations of alternative marine lipid sources rich in n-3 LC-PUFA available in the market were herein evaluated to replace traditional fish oil (sardine oil) in diets for European sea bass (Dicentrarchus labrax). A commercial-type diet (CTRL), containing 1.6% of EPA + DHA, 5% sardine oil and 8% rapeseed oil was used as a negative control. Another diet (SARDINE) formulated with 8.5% sardine oil, 4.5% rapeseed oil and 2.5% EPA + DHA was used as the positive control. Three experimental diets were formulated to completely replace sardine oil with alternative sources, targeting approximately the same EPA + DHA level as the positive control: the SALMON diet contained 9.9% salmon by-product oil mixed with 3.1% of an algal oil rich in EPA and DHA, while the ALGARAPE and the ALGASOY diets included 4.4% of the algal oil and 8.6% of either rapeseed or soybean oil, respectively. A sixth diet (ALGABLEND) was formulated to partially replace sardine oil with salmon by-product oil and rapeseed oil, balanced with 2% of algae biomass. The experimental diets were hand-fed to 118 g fish for 54 days.

Results

All diets were well-accepted by fish and no significant differences were found in feed efficiency, growth performance, somatic indexes or whole body composition among treatments. At the end of the trial, regardless the dietary EPA + DHA level, all fillets contained more than 250 mg of EPA + DHA per 100 g fresh weight, meeting EFSA recommendations for cardiovascular risk prevention for European adults (> 250 mg day -1).

Discussion

Overall, this study demonstrated that combining expensive sources of n-3 LC PUFA (Veramaris® or Algaessence Feed™ with low-priced sustainable oils (salmon by-products oil or vegetable oils) allows fortifying European sea bass flesh with EPA and DHA, without major textural changes. This approach is a successful strategy for mitigating the negative effects associated with the high inclusion of vegetable oils. However, the retention of n-3 LC-PUFA in muscle was not significantly increased, suggesting that there is a maximum dietary threshold beyond which β-oxidation might be promoted, and hence there is no advantage in increasing the dietary level of these fatty acids in European sea bass diets.
A systematic study on the efficacy of low-temperature GaN regrown on p-GaN to suppress Mg out-diffusion
Authors: Lee Kwang Jae , Wen Xinyi , Nakazato Yusuke , Chun Jaeyi , Noshin Maliha , Meng Chuanzhe , Chowdhury Srabanti
Published: December 2023

Embedding p-type gallium nitride (p-GaN) in AlxGa1-xN-based thin films has garnered significant interest as a versatile structure for bandgap engineering such as tunnel/super-junctions or current blocking/guiding functions in electronic devices. However, Mg, a p-GaN dopant, has an undesirable diffusive capacity into the nearby thin films at a high growth temperature (>1,000°C), resulting in structural challenges in device design. This study systematically investigated the low-temperature GaN (LT-GaN) layer regrown on p-GaN that suppresses Mg diffusion according to metal–organic chemical vapor deposition growth conditions. Prototype Al0.3Ga0.7N (40 nm)/GaN (140 nm) high-electron-mobility transistors (HEMTs) were regrown with LT-GaN on p-GaN (300 nm), and a high two-dimensional electron gas (2DEG) density of 3.13E12 cm−2 was achieved by inserting a 100-nm-thick LT-GaN layer grown at 750°C; in contrast, only 1.76E10 cm−2 2DEG density was obtained from Al0.3Ga0.7N/GaN HEMTs regrown directly on p-GaN (Mg: 4.0E19 cm−3). The fabricated Al0.3Ga0.7N/GaN HEMTs with 100-nm-thick LT-GaN demonstrated a high drain current density of 84.5 mA/mm with a low on-state resistance of 31 Ω·mm. The AlxGa1-xN/LT-GaN/p-GaN platform demonstrated here paves the way for various III-nitride-based structures with embedded p-GaN.
Experimental research and engineering application on bearing capacity of concrete-filled steel tube circular arch
Authors: Jun Wang , Chuangen Zhu , Fuli Bo , Guangming Xin , Yan Liu , Bo Wang , Guifeng Dong , Zhaolong Tian
Published: December 2023

The bearing property and deformation failure law of the CFST circular arch were investigated in order to provide direction for the optimization of the concrete-filled steel tube (CFST) support. The flexural bearing capacity test of the 194 mm × 10 mm CFST was performed initially in this study. It was primarily explored how bearing capacity and deformation of circular arches were affected by the slip of the arch foot and anti-bending strengthening, and the neutral layer migration rule and anti-bending strengthening mechanism of circular arches were examined. The bearing performance of the circular arch under the condition of the concentrated load of the vault and the usual uniform load of the entire span is then simulated in an orthogonal test by numerical simulation in order to extend the experimental investigation. The effect of variables including the steel tube’s outer diameter, thickness, slip of the arch foot, and the ratio of the arch rise to span on the bearing capacity of the circular arch is examined. The study demonstrates that under focused stress on the arch top or full-span normal uniform loading, the arch foot slip is the most important element impacting the CFST support’s bearing capacity. In steel tubes with the same outer diameter and wall thickness, the vector span ratio has a bigger influence than anti-bending strengthening. When the span ratio is the same, the influence of the outer diameter and wall thickness are equal and outweigh the influence of bending strengthening. The circular arch with an outside diameter of 168 mm, a wall thickness of 10 mm, and a rise-span ratio of 0.207 has the best performance characteristics under the influence of concentrated load, and the ultimate failure mechanism is local waist drum deformation failure. Based on the aforementioned study findings, the circular CFST support’s buckling deformation and drum deformation are examined, and a composite support consisting of “anchor net spray + CFST support” is directed for the north three deep track downhill of Yangcheng Coal Mine. Two failure types expose the failure mechanism and provide a technique for optimization. The support had contributed to the circular CFST arc arch’s best bearing performance in the event of waist drum deformation and failure.