bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic dilemma- choroidal granuloma as an atypical rare presentation: A case report
Authors:   Vitreoretina Consultant Bharti Eye Foundation and Hospital 1/3 East Patel Nagar New Delhi -110008, India., Ranjan Richa
Published: May 2024

Purpose: To report a rare atypical case of ocular toxoplasmosis presenting as choroidal granuloma in a young adult. Case presentation: A 16-year-old male presented with sudden diminution of vision in the right eye. The visual acuity was 6/12p in the right eye. The anterior segment examination was normal. No relative afferent pupillary defect was present. The fundus examination of the right eye showed grade 1 vitritis, a normal disc with a well circumscribed active choroidal lesion on the posterior pole, inferior to the fovea along with surrounding Subretinal Fluid (SRF) pocket. The Optical Coherence Tomography (OCT) of the right eye showed choroidal elevation with the highest dimension just inferior to the fovea, along with surrounding SRF at the fovea. Fluorescein angiography showed punctate hyperfluorescent leakage points around the lesion. Intervention: Blood hemogram was normal with a raised erythrocyte sedimentation rate. Serological screening was positive for toxoplasmosis (IgM and IgG antibodies). Human Immunodeficiency Virus (HIV) and tuberculosis (QuantiFERON Gold test) were negative. Oral medications spiramycin 500 mg three times a day for 3 weeks along with folic acid once a day was started after paediatrician consult. Result: Follow up at 1 week, the visual acuity improved to 6/9 and the choroidal elevation along with the SRF was resolving on the OCT scan. After 3 weeks of treatment the visual acuity improved to 6/6 and the fundus showed complete resolution of the choroidal granuloma along with the surrounding SRF with no residual chorioretinal scar formation. Conclusions: Our case reports a rare atypical presentation of ocular toxoplasmosis with only one more case available in the literature of ocular toxoplasmosis presenting as a posterior pole choroidal granuloma. Timely intervention lead to complete resolution of the lesion and complete restoration of the visual acuity.
A rare case of capgras syndrome: The impersonation delusion
Authors:   House Officer, Dr. Akbar Niazi Teaching Hospital, Islamabad, Pakistan., Ali Mohammad
Published: May 2024

Capgras syndrome is a rare psychiatric disorder characterized by the delusional belief that a person or people close to the affected individual have been replaced by identical impostors. This case report presents the unique clinical presentation and management of a 52-year-old male patient who exhibited classic symptoms of capgras syndrome. The patient’s delusion emerged following a traumatic brain injury, leading to significant distress and impaired social functioning. The assessment, diagnosis, and treatment approach are discussed, highlighting the interdisciplinary collaboration between psychiatry, neurology, and neuropsychology. This case report sheds light on the challenges associated with the management of capgras syndrome and emphasizes the importance of a comprehensive and individualized treatment plan.
Acute myocarditis or apical balloon cardiomyopathy in a patient with systemic lupus erythematosus: The priority of common sense
Authors:   Second Department of Cardiology, University of Ioannina Medical School, University Campus, Stavros Niarchos Avenue, Ioannina, 45 500, Greece., Bouratzis Vasileios
Published: May 2024

Myocarditis can mimic takotsubo cardiomyopathy and via versa. We present a 70‐year‐old woman with known systemic lupus erythematous who presented to the emergency department twice during the last 2 years with chest pain, dyspnea and transient LV dysfunction. We also discuss the difficulties in differential diagnosis between lupus myocarditis and takotsubo cardiomyopathy.
Placenta accreta spectrum in unscarred uterus: A case report in a tertiary facility
Authors:   Department of Obstetrics and Gynecology, Bugando Medical Centre, Catholic University of Health and Allied Sciences, Tanzania., Augustino Onesmo
Published: May 2024

Background: Placenta Accreta Spectrum (PAS) is a broad term that includes placenta accreta, placenta increta, and placenta percreta. The major risk factor is a scarred uterus commonly as a result of prior cesarean delivery, myomectomy, or uterine instrumentation. We report a case of placenta increta in the absence of identifiable risk factors. Case presentation: A 22-year-old, para 2 living 2, presented with postpartum hemorrhage due to retained placenta post vaginal delivery at a gestational age of 38 weeks and 4 days, manual removal of placenta was attempted general anesthesia without success; necessitating explorative laparotomy where the placenta was found deeply invading into the myometrium. Intractable bleeding necessitated supracervical hysterectomy. Histopathological results later revealed placenta increta. Conclusion: PAS in an unscarred uterus in the absence of other identifiable risk factors is quite uncommon; however, carries high maternal morbidity and mortality. This case serves as an eye opener on the need to evaluate for radiological features of PAS during antenatal visits even in low-risk group.
Atypical presentation of syringomyelia mimicking as motor neuron disease: A case report
Authors:   Jose R Reyes Memorial Medical Center, Department of Neurology, Manila, Philippines., Sabellano Zenyros FA
Published: May 2024

This is a case involving a 27-year-old Filipino female who presented with a chief complaint of progressive weakness in all extremities. The initial assessment of the patient’s clinical history and the neurologic examination revealed the presence of a motor neuron disease. This conclusion was drawn based on the observation of both upper and lower motor neuron signs. Furthermore, the findings from the Electromyography (EMG) Nerve Conduction Velocity (NCV) findings suggest active and chronic generalized disorder of motor neurons. However, craniospinal MRI revealed the presence of a long segment C1-T12 syringomyelia, accompanied by an extradural, extramedullary cystic mass at the T12 to L1 level. This paper is the first one to report an atypical presentation of syringomyelia as a motor neuron disease secondary to a non-chiari malformation.
Benign subcutaneous emphysema after insect bite
Authors:   Rasool-e-akram General Teaching Hospital, School of Medicine, Iran University of Medical Sciences, Iran., Talebi-Taher Mahshid
Published: May 2024

A 16-year-old girl presented to the emergency department with a several days history of insect bite to the dorsal aspect of the left hand. Initially the swelling was localized to the dorsal hand, over the following four days the swelling became more diffuse involving the whole left forearm, arm, axilla and left hemithorax. She reported no fever.
Systemic onset juvenile idiopathic arthritis associated with Agammaglobulinemia: A brief report
Authors:   Professor in Pediatric Rheumatology, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shiari Reza
Published: May 2024

Systemic onset Juvenile Idiopathic Arthritis (SJIA) is defined as a systemic inflammatory disease. Innate immune system dysregulation and systemic inflammation are the autoinflammatory pathogenesis of this disease. The clinical manifestations are fever, arthritis, lymphadenopathy, rash, and serositis. Of the manifestation of immune deficiency is recurrent otitis media. Recurrent otitis media should be evaluated for immune components. In this report, we presented a boy with recurrent otitis media, pain and swelling in both knees, and fever which fever was exacerbated at nights and he had no fever during day. After immune system evaluations, autosomal recessive agammaglobulinemia was observed in genetic test.
Sister Marie-Joseph’s nodule reveals gynaecological cancer
Authors:   Radiology Department, National Institute of Oncology, Rabat, Morocco., Zohra Benbrahim Fatima
Published: May 2024

The Sister Mary Joseph nodule is a rare umbilical metastasis of abdominopelvic cancer, easily accessible on clinical examination, and often correlated with a poor prognosis. Its recognition as a secondary lesion allows early diagnosis and treatment.
Unusual presentation of antepartum lumbosacral plexopathy: A rehabilitation approach
Authors:   Physical Medicine and Rehabilitation, St. John’s National Institute of Medical Sciences, Bangalore, India., Debnath Anindya
Published: May 2024

Background: This case report focuses on a woman in her late thirties (gravida three para three) referred from Neurology to Physical Medicine & Rehabilitation department due to pain, lower limb weakness, walking difficulties, and dependence in daily activities. Her symptoms, which began during the second trimester of pregnancy, progressed from burning sensations in her feet to muscle weakness affecting her legs and thighs in the peripartum period. Case presentation: Following delivery, diagnostic investigations indicated lower creatine phosphokinase levels, MRI findings showed muscle atrophy in the posterior compartment of both thighs, and an electromyography and nerve conduction study confirmed bilateral lumbosacral plexopathy. Treatment and outcomes: Rehabilitation commenced six weeks postpartum, but the patient faced challenges due to her functional limitations. The treatment included a multifaceted approach encompassing medical management, physical therapy, and occupational therapy. Notably, the patient demonstrated significant improvement within two weeks of inpatient rehabilitation. Conclusion: This case underscores the effective management of antepartum lumbosacral plexopathy using a comprehensive rehabilitation strategy. Early intervention and a multidisciplinary approach are pivotal in achieving positive outcomes in similar clinical presentations.
Experimental Evaluation of Mechanical Properties, Micro Structure and Post-Fire Strength of Fiber Reinforced Geopolymer Concrete
Authors: Seyed Mohammad Mirhosseini, Mohammad Javad Taheri Amiri Abbasali Saffar, Mohammad Ehsanifar,
Published: May 2024

Geopolymer mixtures offer an enhanced alternative to implement an eco-friendly solution in construction industry. These mixtures exhibit similar or better mechanical and structural properties in comprising of cement and can use recycling and by-product materials. Against this background, an eco-friendly advantageous were achieved from the engineers and researchers by using waste materials to replace cement and attention to reduce CO2 emission during its procedure. This study attempted to evaluate compressive and tensile strength, micro structure and post-fire characteristic of the geopolymer mixtures. For this aim, the geopolymer mixtures were exposed to elevated temperature between 200, 500 and 800 0C. Then, the post-fire and mechanical behaviour were investigated. The proposed research supported the slight decrease in the GPC's compressive stress by fibres, and the 1.25% PP fibres displayed the least performance, indicating nearly 13% decrease than the unreinforced mixtures. As exhibited by the post-fire behaviour of mixtures, the GPC's compressive strength increased first for all mixes but in the range of 400 - 800°C it decreased at a higher rate because of the geopolymer matrix-related dehydration. Besides, fiber melting under high temperatures and the thermal reaction procedure related to free water evaporation reduce the mechanical properties under temperatures ranging from 400°C to 800°C.
DOI: https://doi.org/10.52783/pst.349
A conceptual study on challenges in web merchandising
Authors: C. Thirumal Azhagan  , R. Ragul
Published: May 2024

Web merchandising presents a countless of challenges for online retailers seeking to establish and maintain a competitive edge in the digital marketplace. This study examines the multifaceted hurdles faced by e-commerce businesses, encompassing factors such as intense competition, consumer behavior, data management complexities, personalization demands, mobile optimization imperatives, SEO, dynamic pricing considerations, security and fraud prevention measures. Retailers need to take a complete approach that combines modern technology, data analytics, and an in-depth understanding of consumer preferences in order to successfully manage these issues. Businesses may improve client interaction, boost online visibility, and promote long-term success in the dynamic field of web retailing by taking on these difficulties directly.
Sentencias comentadas. Los contornos del límite de cita como excepción al derecho exclusivo de reproducción del autor de una obra protegida por la propiedad intelectual (Comentario a la sentencia del Tribunal Supremo 724/2023, de 16 de mayo)
Authors: Moralejo Imbernón Nieves
Published: May 2024

La sentencia sobre la que versa este comentario aborda los contornosdel límite de cita dentro de nuestro ordenamiento jurídico, como excepción alderecho exclusivo de reproducción que tiene el autor sobre su obra. La valoraciónde la concurrencia de los presupuestos para que opere tal limitación,en un caso en que el objeto de la cita había sido una obra literaria derivada(una traducción), conduce al Tribunal Supremo a desestimar el recurso decasación interpuesto por la editorial demandada y a confirmar el pronunciamientode la instancia, tanto en lo relativo a la existencia de una infraccióncomo a la indemnización fijada por la Audiencia Provincial de Madrid enapelación.
Sentencias comentadas. Cuatro Sentencias del Tribunal Supremo sobre la resolución por frustración del fin del contrato: entre la causa y el aliud pro alio
Authors: Araque García Alejandro
Published: May 2024

A lo largo del pasado año 2022 el Tribunal Supremo ha dictado cuatro Sentencias, en buena parte paralelas, en las que se enfrenta con la posible resolución de unos contratos de compraventa inmobiliaria a raíz de la alteración sobrevenida de las circunstancias urbanísticas. En todas ellas demandaba la resolución el comprador, una promotora que entendía que la modificación del planeamiento frustraba la finalidad de su adquisición. El Tribunal Supremo falla en todos los casos a su favor, manejando doctrinas tan dispares como la del aliud pro alio, la causalización del contrato o las condiciones tácitas, desechando en cambio la alternativa empleada por alguno de los tribunales de instancia de servirse de la rebus sic stantibus. Según la doctrina de estas Sentencias, si la modificación sobrevenida del planeamiento provoca que no se puedan utilizar las fincas adquiridas para el fin urbanístico previsto, la resolución es posible, debiendo devolverse las cantidades vinculadas al fin que se pagaron, pero no aquellas que parecían funcionalmente constituir una opción de compra futura.
疫情下人性化溝通的家庭會議
Authors: 李靜怡 李靜怡 , 黃獻樑 黃獻樑
Published: May 2024

家庭會議對醫療決策十分重要，特別在安寧緩和及加護病房照護等範疇，扮演重要的角色。健保署為鼓勵臨終安寧緩和，在2012年新增給付「緩和醫療家庭諮詢費」，並在2015年調整諮詢費及擴大給付範圍，使台灣民眾日益接受安寧緩和醫療的觀念。

不過，家庭會議面臨不少問題，當中醫師的溝通技巧對家庭會議成功與否，有著舉足輕重的影響，因此，一套有效的溝通模式必不可少。台大醫院致力將人性化溝通融入於家庭會議，例如，嘗試把VALUE及PLACE兩種溝通模式，應用在醫病共享決策(shared decision making,SDM)，成果顯示有助於在臨床實務實踐人性化溝通。未來，希望推動人性化醫病共享決策，成為醫療常規之一。

 

Family conferences facilitate medical decision making, especially in the fields of palliative care and intensive care. Taiwan’s National Health Insurance started covering family conferences for palliative medicine in 2012 and has increased the coverage and budgets since 2015 with the goal of promoting general acceptance of palliative medicine in Taiwan.

 However, there are many difficulties in holding family conferences whose success relies to a great extent on physicians’ communication skills. However, better clinical outcomes of and patient satisfaction with shared decision-making can be achieved by humanizing communication with more empathetic approaches like VALUE (Value, Acknowledge, Listen, Understand, and Elicit) and PLACE (Prepare, Listen, Agree, Connect, and Explore). This is of particular significance during times of pandemic. It is our hope that, in the future, shared decision-making with the help of humanized communication approaches is advocated to be the standard medical practice in different fields, not restricted to palliative care.

 
原發性肺癌合併胃部轉移：個案報告
Authors: 沈宜萱 沈宜萱 , 柯澐蓁 柯澐蓁
Published: May 2024

原發性肺癌是臨床上常見的癌症，目前研究對於肺癌的診斷、臨床及病理表現、治療等等日新月異。然而，原發性肺癌合併腸胃道轉移的個案則是相當罕見，因為其常以無症狀或非特異性症狀表現，在臨床上容易被忽略或誤診。原發性肺癌合併胃部轉移與原發性胃癌在組織學的表現十分相似，需要依靠免疫組織化學染色（包含腫瘤細胞角蛋白7 (CK7)、甲狀腺轉錄因子-1 (TTF-1)、腫瘤細胞角蛋白20 (CK20)）協助鑑別診斷。此篇病例報告呈現一位原發性肺癌合併胃部轉移的個案，臨床表現包含長久的消化不良以及體重減輕，在追蹤期間被診斷為化療造成的不適，最後經免疫組織化學染色確診為原發性肺癌合併胃部轉移。

 

Primary lung cancer is very common and fatal. However, cases of primary lung cancer with gastrointestinal metastases are relatively rare. We present a case of gastric metastasis from primary lung adenocarcinoma with clinical manifestations including dyspepsia and weight loss. The patient was initially thought to undergo chemotherapy-induced side effects but later diagnosed as gastric metastasis from primary lung cancer (GMLC) through special immunohistochemical staining of tissue for thyroid transcription factor-1 (TTF-1) and cytokeratin-7 (CK-7). Since the gastrointestinal (GI) tract remains a rare site of metastasis of primary lung cancer, GMLC is primarily described in case series. The incidence is considered underestimated, and the main reason is that it mostly presents with asymptomatic and nonspecific symptoms which sometimes may be regarded as the side effects of chemotherapy, hence misidentified as primary gastric cancer. Complications such as acute gastric bleeding and gastric perforation occur in patients with gastric metastasis and may result in death in severe cases. The presentation of gastric metastasis is difficult to differentiate from primary gastric cancer under endoscopy, leading to misdiagnosis and inadequate treatment. As the histological appearance of primary lung cancer with gastric metastasis is highly similar to that of primary gastric cancer, immunohistochemistry (IHC) staining is needed to assist in differential diagnosis.

 
認知風險、預防行為與旅遊規避- COVID-19知識的調節效果
Authors: 張文榮 張文榮
Published: May 2024

目前COVID-19所帶來的重大且深遠影響已對經濟、社會和健康造成獨特的衝擊。有鑑於COVID-19的高感染率，積極投入COVID-19的預防工作以減少COVID-19感染死亡率是必要的。因此，後疫情時代的旅遊振興是政府必須認真看待的問題。在現有文獻，逃避現實已被視為旅行的一個重要動機因素。目前COVID-19相關研究大多集中在醫療效應或心理壓力，而COVID-19行為和旅遊意圖則是很少見。基於來自台北市和新北市的270個有效樣本，本研究使用結構方程模型檢驗COVID-19認知風險(PER)、預防行為(PREV)和旅遊規避(TA)之間的關聯性，以及COVID-19知識(KN)的調節效應。實證顯示：COVID-19認知風險可以透過預防行為影響旅遊規避，然而COVID-19認知風險無法直接影響旅遊規避；COVID-19知識對預防行為和旅遊規避之間的關係具有調節作用。

 

The massive and profound impact of the current pandemic (i.e., COVID-19) has posed unique economic, social, and health challenges. Given the high prevalence of COVID-19 infection, more active involvement in COVID-19 prevention is needed to reduce mortality from COVID-19 infection. Therefore, the revival of tourism in the post-epidemic era is an issue that the government must take seriously. Within extant literature, escapism has been posited as a key motivation factor for travel. Today, studies related to COVID-19 has mostly focused on the medical effects or psychological aspects of stress; little research has been conducted on COVID-19 behaviors and travel intention. Based on 270 valid samples from Taipei CITY and New Taipei City, this study used structural equation modeling to examine the relationships among perceived risk of COVID-19 (PER), preventive behavior (PREV) and travel avoidance (TA) as well as the moderating effect of COVID-19 knowledge (KN). Empirical results indicate that PER can influence TA through PREV, whereas PER cannot directly impact TA; KN has a moderating effect on the relationship between PREV and TA.

 
評《社會福利行政》
Authors: 張雄盛 張雄盛
Published: May 2024

本文介紹《社會福利行政》一書的重點內容及特色。從整理爬梳公共行政與管理學的發展過程，吾人能將「社會福利行政」理解為運用管理原理（方法）於政府社會部門組織運作與推動社會福利政策，故本文贊同作者主張的「管理原理運用於福利組織的限制」。其次，從探討國內其他《社會福利行政》教科書的過程中，發現本書更聚焦於社會福利行政內涵與執行過程，而是強調管理的運用與行政的執行面，包括社會福利機關的法制環境、運作環境、公共關係與危機處理等。最後，本文建議可增加基層的行政人員所需的行政技術的案例說明或作業練習，以及從批判觀點探討社會福利行政體制內的結構的不平衡與權力關係，或從個人經驗出發的內容，以擴增本書的觀點。

 

This article introduces the key contents and characteristics of the book ’’Social Welfare Administration’’. From sorting out the development process of public administration and management, we can understand ’’social welfare administration’’ as the application of management principles (methods) to the organizational operations of government social departments and the promotion of social welfare policies. Secondly, from the process of discussing other domestic ’’Social Welfare Administration’’ textbooks, I found that this book focuses more on the connotation and implementation process of social welfare administration, but emphasizes the application of management and the execution process of administration. Finally, this article suggests that this book can add case descriptions of administrative techniques or homework exercises for grassroots bureaucratic staff, and to increase the critical perspective on structural imbalances and power relations within social welfare administrative bureaucracies, or add content based on personal experience to expand the book’s perspectives.

 
Lipocalin-2 as a marker of inflammation, bone density, and triglyceride-glucose index for new-onset arthritis patients in Mosul, Iraq
Authors: Saadon Safa Rabea , Allwsh Thikra Ali
Published: May 2024

Objective: Lipocalin-2 is an acute phase-associated adipokine that can serve as an inflammatory and biomarker indicator of cartilage deterioration in osteoarthritis. However, its role in the musculoskeletal system remains not fully understood. Hence, this study aimed to evaluate lipocalin-2 and its relationship with markers of inflammation (Interferon-gamma, ESR, and CRP), bone density (vitamin D3 and calcium), and the triglyceride-glucose index in new-onset arthritis patients in Mosul, Iraq.

Methods: This study included 125 participants aged 20 to 65, divided into two groups. The Arthritis Patient Group comprised 70 participants (37 females and 33 males) attending the Bone Diseases Consultation Unit at the Ibn Sina Teaching Hospital in Mosul, Iraq. The Control Group comprised 31 females and 24 males. Ethical approval was obtained from the Iraqi Ministry of Health - Nineveh Health (No. 2022095).

Commercial ELISA kits were used to measure serum lipocalin-2, Interferon-gamma, ESR, and CRP as inflammation markers, vitamin D3, and calcium as bone density markers. Moreover, the Triglyceride Glucose (TYG) Index was evaluated.

Results: The findings revealed a significant increase in lipocalin-2 levels in males compared to females, with LCN-2 increasing with age. Arthritis patients showed a significant increase (72%) in lipocalin-2 levels. Inflammatory indicators (erythrocyte sedimentation rate, C-reactive protein, interferon-gamma) displayed significant increases (46%, 1200%, and 581%, respectively). Glucose (23%), triglycerides (71%), and TYG index (21%) also exhibited significant increases. Meanwhile, bone density indicators (vitamin D3 and calcium) found a significant decrease (53% and 20%, respectively) in arthritis patients.

Linear correlation coefficient (R) analysis revealed a significant positive relationship between lipocalin-2 and indicators of inflammation, glucose, TG, and TYG index.

Conclusion: This study’s findings suggest that LCN-2 serum levels were higher in patients with new-onset arthritis than in controls in Mosul, and LCN-2 serum increased in males compared with females and getting older serum LCN-2 increased for the patients and control groups. Furthermore, a significant correlation was found between the Triglyceride Glucose Index, which measures metabolic disorders, and serum LCN-2 levels and inflammatory indicators in new-onset arthritis patients in Mosul, Iraq.
ALLOWANCES TRADING MARKET - INTERNATIONAL EXPERIENCE AND RECOMMENDATIONS FOR VIETNAM
Authors: Thi Minh Dr. Le
Published: May 2024

The allowances market (the mandatory market or ETS market) is considered an effective method to ensure control of greenhouse gas emissions and not hinder economic development. This article introduces the nature of greenhouse gas emissions and the allowances market. The article outlines factors that must be considered and controlled to ensure the market operates safely. The article provides some recommendations for Vietnam in building a framework for the allowances market.
Obesity as a risk factor after cardiovascular surgery
Authors: Carvalho Rafael , Fantinelli Renan , Mendes Luiza , Montanhini Laura , Cola Paula , Herculiani Cristóvam
Published: May 2024

Cardiac surgery is surgical procedure, so, as every surgery, there are risks, including in the postoperative period. Obesity can be a raising factor for complications during the surgery process, in the postoperative period and treatment, as it is frequently associated with various metabolic disorders and complicates access to the heart, being, therefore, a very important analysis for clinical practice.
Estudo de família no contexto da Atenção Primária à Saúde: ferramentas de abordagem familiar
Authors: Rodrigues Pacheco João Paulo , Caldeira de Faria Santiago Marianne , Amâncio Martins Andréia Christiane , Oliveira de Souza Boitrago Sarah Caroline
Published: May 2024

A família pode ser definida como uma unidade social representada por vínculos estabelecidos entre seus membros, em contextos como organização, estrutura e funcionalidade. Este estudo teve como objetivo analisar as ferramentas de abordagem familiar, considerando o estudo de famílias no contexto da Atenção Primária à Saúde. Trata-se de uma revisão narrativa da literatura, através da busca de artigos científicos, nas bases de dados LILACS, MEDLINE e SCIELO. O trabalho com famílias requer o desenvolvimento de uma relação baseada na compreensão do funcionamento sistêmico da família e na aplicação do método clínico centrado no paciente. As ferramentas de abordagem familiar são tecnologias relacionais que visam estreitar as relações entre profissionais e familiares, promovendo a compreensão em profundidade do funcionamento do indivíduo e de suas relações com a família e comunidade. Essas ferramentas permitem o conhecimento pela equipe sobre o padrão patológico familiar, garantindo a assistência direcionada, de acordo com as necessidades apresentadas.
Compostos fenólicos a partir de vegetais: uma revisão sobre os métodos de quantificação e avaliação das propriedades antioxidante e antimicrobiana
Authors: Cavalcante Marília de Almeida , Borges Wardsson Lustrino , Souza Tiago Marcolino de
Published: May 2024

Os compostos fenólicos são obtidos a partir dos vegetais utilizando diferentes métodos de extração, sendo amplamente utilizados por apresentar diversas propriedades biológicas. Neste contexto, a identificação e quantificação desses compostos nos extratos vegetais e o estudo de suas propriedades torna-se importante. Esta revisão tem como objetivo apresentar os diferentes métodos usados identificação e quantificação dos compostos fenólicos bem como da avaliação de suas propriedades biológicas. Os métodos de identificação e quantificação incluem espectrofotometria e cromatografia gasosa e líquida. A partir da pesquisa foi possível demonstrar as principais vantagens e desvantagens dos métodos utilizados para identificação, assim como a descrição da atividade antioxidante e antimicrobiana e os diversos métodos para avaliação.
DEVELOPMENT AND EVALUATION OF DOMPERIDONE ORAL FILM USING MIXED SOLVENCY CONCEPT
Authors:   Department of Pharmaceutics, Faculty of Pharmacy, B.R. Nahata College of Pharmacy, Mandsaur University, Mandsaur – 458 001, Madhya Pradesh, India, Tomer Kirti , Jain Amit Kumar , Gehlot Neha
Published: May 2024

a *, a and a a * For Correspondence: E-mail: kirtitomarmip@gmail.com https://doi.org/ ABSTRACT This study aimed to develop and evaluate oral film of antiemetic drug-using mixed solvency concept. The mixed-solvency concept was used in the solubility enhancement of domperidone, an antiemetic drug that is practically insoluble in water. Different types of solubilizers have been used for solubility improvement of domperidone and poly ethylene glycol, niacinamide, caffeine were found to be effective. Five formulations were prepared by using HPMC E15 a film-forming polymer. The prepared oral films were subjected to evaluation for thickness, pH, drug content, folding endurance, stability and in vitro drug release profile. The % in vitro drug release of the best two formulations F3 and F5 were 90.70% and 96.62 % respectively. From the above study, it was concluded that the solubility of the practically insoluble drug, domperidone could be improved successfully by using different water-soluble solubilizers in different ratios under the mixed-solvency concept.
DESIGN AND OPTIMIZATION OF OCULAR INSERTS FOR PROLONGED DELIVERY OF CIPROFLOXACIN WITH CORTICOSTEROID
Authors:   Department of Pharmaceutics, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda- 403 401, Goa, India, Keny Swati M. , Sawaikar Leena A. ,   Department of Pharmaceutical Chemistry, PES’s Rajaram and Tarabai Bandekar College of Pharmacy, Farmagudi, Ponda-403 401, Goa, India, Savaikar Anushka ,   Department of Chemistry, PES’s Shri Ravi Naik College of Arts and Science, Farmagudi, Ponda- 403 401, Goa, India
Published: May 2024

Ocular drug delivery is very challenging and fascinating for pharmaceutical researchers, especially in the treatment of ocular conjunctivitis. The challenges include delivery of the drug to the eye without causing permanent tissue damage while maintaining a stable therapeutic level at the site of action for a prolonged period of time. The present work focuses on the treatment of ocular conjunctivitis by using combined mechanisms of fluroquinolone antibiotics, providing sustained release of drug from ocular inserts, and using corticosteroid for anti-inflammatory effect and providing comfort to the patient. Quinolone antibiotics, anti-inflammatory agents and polymers with excipients were procured from pharmaceutical companies as gift samples. Different combinations of antibiotics and anti-inflammatory agents were prepared by solvent cast method and the dried films were cut into defined size containing drug and evaluated for different parameters and sustained drug release. Based on in vitro, in vivo correlation stability studies, the formulation (antibiotic + anti-inflammatory agent) promising the best once a day sustained release of the drug has been chosen.
Biojoias artesanais e geração de renda no litoral do Paraná
Authors: Anacleto Adilson , Souza Beatriz Milet de , Christakis Carolina Mendes , Farias Gabrielli de Lima , Fary Marcelle Renata Cotelesse
Published: May 2024

A produção de artesanato tem se revelado como alternativa de renda para diferentes grupos sociais, e dentre as inúmeras variações desse segmento no litoral do Paraná, destaca-se a produção e o comércio do artesanato classificado como biojoias. No entanto, poucos estudos foram encontrados sobre a temática. Assim, diante do exposto, esta pesquisa objetivou organizar um panorama sobre a produção e o comércio de biojoias artesanais como alternativa de geração de renda no litoral do Paraná. Foi realizada entre junho e dezembro de 2023 uma pesquisa exploratória descritiva por meio de entrevistas com nove artesãos referência na região, que concordaram voluntariamente em participar da pesquisa. O estudo revelou que as mulheres eram a totalidade dos entrevistados, com idade média de 55,1 anos. A maioria das entrevistadas (n=80%) era originária de famílias socialmente vulneráveis, com histórico de violência doméstica e cor parda. Os fatores mais positivos na atividade foram a renda financeira obtida, a produção de qualidade e a valorização da mulher profissional. Os fatores mais negativos foram a renda insuficiente para sobreviver apenas da atividade, pouca divulgação das biojoias e a falta de apoio do poder público.A produção de biojoias, segundo as entrevistadas (n=80%), contribuiu para resgatar a autoestima e dar novo significado às suas vidas, possibilitando melhores condições também para suas famílias.
Implementasi Strategis Sistem Informasi Akuntansi Melalui Analisis Komparatif
Authors: Adinda Dwi Arini
Published: May 2024

This research aims to investigate the strategic implementation of accounting information systems (AIS) through a comparative analysis of various approaches employed within organizations. In the face of rapidly changing business dynamics, the role of AIS is pivotal in supporting accurate managerial decisions and ensuring operational sustainability.The research methodology involves data collection from multiple organizations that implement AIS using distinct approaches. A comparative analysis is conducted across various implementation aspects, including system design, technological integration, data management, information security, and their impacts on financial and operational performance within the companies. The findings reveal that a strategic approach in implementing AIS provides a competitive edge for organizations. It was identified that factors such as appropriate technology selection, efficient integration, robust data security, and integrated management significantly contribute to the success of AIS implementation.These findings offer valuable insights for practitioners and managers in planning, developing, and enhancing the effectiveness of AIS in the context of dynamic market changes and business environments. The implications of this research provide a foundation for organizations to make strategic decisions regarding AIS investments and implementation to enhance their competitiveness and operational performance.
The Atlas of Religious or Belief Minority Rights in the EU: First remarks on Belief Organisations
Authors: Baldassarre Silvia
Published: May 2024

ABSTRACT: This paper focuses on the first results of the Atlas of Religious or Belief Minority Rights in the EU regarding the legal status of Belief Organisations. The first part of this work describes “Belief Organisations”, focusing on why they are included in the Atlas, and analyses the growth of atheism and agnosticism in the countries covered by the project. The second part focuses on some of the findings that emerge from Atlas data, providing a few (provisional) remarks.

SUMMARY: 1. The Atlas of Religious or Belief Minority Rights in the EU: a brief introduction - 2. Belief Organisations as actors in the religious field - 3. The religious demography of atheism and agnosticism - 4. About Belief Organisations - 5. Focus on Belief Organisations: first findings.
Theatrical Release Windows: A Playground for “Cultural Exception” Policies?
Authors: Fanchi Mariagrazia , Locatelli Massimo
Published: May 2024

In recent years, cinema culture in Europe has undergone a substantial reorganization of production models and a profound change of public intervention in favor of the film industry. This article aims to reconstruct the different combinations between protectionist and liberalist policies through a comparative analysis of the contemporary European national cinema aids, identifying differences and shared trends and verifying the existence of a “continental” cinema support model. Therefore the article will analyze public support policies on cinema production, distribution, and exhibition in the EU and in several of its member states (including France, Germany, England, Spain, and Italy) from 2018 to 2022. Focusing on theatrical release windows, this essay will attempt to answer the following main questions: is there a “European” mark in policies in favor of cinema? Can we speak of a “European” model (even outside the European Union) of support for the cinema? What are the elements and actions that define it? What are the sectors of the industry in which it is most fully expressed (production, distribution, exhibition)? And what are the themes and areas in which, on the contrary, national differences (sometimes driven by resurgent nationalisms) are most marked?
Cinema Co-production, Film Distribution in Multiple Languages and Inequality in the Global Language System: A Call for Robust Public Data
Authors: Vogel Ann , Shipman Alan
Published: May 2024

Language has proven to be an important factor in film performance models, film finance considerations, and festival program selections. This essay uses multi-year global data sets (UN and supplementary databases) to analyse the relationship between the languages in which a film is produced and offered to cinemagoers on the one hand, and the co-production activities and dynamics which engender these patterns on the other hand. While European Commission policies, underlining the peculiar “linguistic polity”of the European Union, have been influential in the making of multilingual cinema productions motivated by subsidy rules, taxation and grant schemes, the pattern is rather global, reflecting uptake of cinematic product in many “territories” and the mobilization of film across national and regional language divides. The analysis shows that Europeanization has much wider implications beyond Europeans’ cultural consumption and identity construction, with Europe’s co-production policies casting a wider net of cultural resistance to Global Hollywood and its majority of English-language blockbusters as well as attending to language preservation in the European neighborhood in addition to Europe, where local and regional heritage policies are well instituted. The study examines the results against Abram de Swaan’s theory of the Global Language System, examining the Q-value theory to the language patterns emerging from film productions with multiple languages, which must be assessed in its relation to cultural consumption that may not follow from formal schooling and habitus formation.
Correlation between Physical Activity Time Reported by the IPAQ and Accelerometer in Syrian Adults
Authors: Al-Bachir Mahfouz , Ahmad Husam
Published: May 2024

Background: The accelerometer and self-report questionnaires have been recommended as efficient methods to measure physical activity (PA). The aim of this work is to investigate issues associated with PA assessment using the ActiGraph WGT3X-BT (AG) accelerometer and the Syrian version of the International Physical Activity Questionnaire-short form (IPAQ-SF-SY) in adults living in Damascus city.Methods: A sample of 52 (age 18- 60 years) Syrian men (17) and women (35) in a cross-sectional study wore the AG accelerometer for seven days and completed the IPAQ-SF-SY on the seventh day. Total PA, time spends in standing and sitting assessed by IPAQ-SF-SY and AG accelerometer were compared.Results: The IPAQ-SF-SY overestimates PA time among Syrian adults. IPAQ-SF-SY reported more time of total PA [763(660) vs 607(149) min, p=0.003], vigorous PA [29(1) vs 1(0.2) min, p=0.524], moderate PA [94(76) vs 42(22) min, p=0.032], MVPA [122(106) vs 43(22) min, p=0.019], and significantly less sedentary time than AG accelerometer [447(180) vs 643(93) min, p=0.728], mean (SD) respectively. Some differences were noticed in the correlations by gender, age, BMI, education statues, and smoking for PA and sedentary behavior (SB). For all correlations, there were no significant differences between sub groups.Conclusions: Data suggest that it is important to improve the specificity and sensitivity of the IPAQ-SF-SY with Arabic-speaking subjects and further study is needed to approve the utilization of PA self-report in Arabic.
Figura-azioni canzonettistiche del corpo di Pinocchio: ricostruzioni del personaggio replicante nell’immaginario nazionale dalla forma-canzone al musical
Authors: Bertoloni Luca
Published: May 2024

In this essay we analyze the figurations of the character of Pinocchio within the Italian song-writing imaginary, studying them from a morphological, transmedia and sociosemiotic point of view, and considering as an epistemological horizon his status as popular and replicating character. From the analysis of this models, it emerges how its nature as a hybrid puppet in transformation represents the narrative shred that guarantees the cohesion of a transmedia ecosystem that evolves into song along a plural path, which manifests itself through relational tensions, visual expansions, and bodily and figurative overlaps, which solicit visual and performative elements. In this way Italian song contributes to the portrait of the transmedia Pinocchio, feeding its ecosystem through new and unprecedented access points and views.
Puer digitalis. Il corpo tecnologico di Pixnocchio.
Authors: Vita Martina
Published: May 2024

“Pixnocchio” has known as the first computer and digital animation in Italy. Created by Guido Vanzetti and Giuseppe Laganà, this short film shows Pinocchio as a digital body in evolution, formed by geometric volumes and colors. Digital animation allows to create a peculiar style combining traditional technique and computer technology: in this way “Pixnocchio” is nothing more than a hybrid animated film, that fits into the Italian videoartistic context of early ’80. The digital body of “Pixnocchio” seems like the new artistic representation of the contempo- rary italianity.
Quando Pinocchio incontra Renzo & Lucia. Parodia della Bambina dai capelli turchini nella Fata di Anna Marchesini (in guisa di Gina Lollobrigida)
Authors: Tamborrino Matteo
Published: May 2024

The papers aims to analyze the performance given by the actress Anna Marchesini (1953-2016) in the television drama “I promessi sposi” (1990), which sees her disguised as the iconic Blue Fairy played by Gina Lollobrigida (1927-2023) within the cult movie “Le avventure di Pinocchio” (1972), directed by Luigi Comencini and based on the homonym novel by Carlo Collodi. The imitation of the well-known star was in fact one of the most important “workhorses” in Marchesini’s comic repertoire. The essay makes use of the contribution offered by the audiovisual document (available in full version on RaiPlay platform) and Tullio Solenghi’s oral testimony, collegue and sidekick in that parodic sketch.
La storia dell’esercizio cinematografico di provincia in tre momenti storici. Il caso di Gardone Val Trompia
Authors: Darelli Virgil
Published: May 2024

The article uses a microhistorical approach to Gardone Val Trompia’s movie theatres. Using archives, local newspapers and other sources, it retraces historical change in management’s forms of out-of-the-city exhibitors. The aim is to highlight their radical difference: never cinema-only venues and always entangled with the local administration and civil society. Three particular moments are discussed: the origins of rural cinema among politicized mutualistic societies; the dominance of non-profit venues during the fascist era, especially those managed by Opera Nazionale Dopolavoro; the renewal and ‘professionalization’ in the mid-1950s. It is also discussed how the government license impacted locally on the cinemas’ existence.
Clinical tutoring for nursing students: analysis of the Barletta-Andria-Trani Health Facility experience
Authors: Ruta Federico , Massaro Michele , Dibenedetto Beatrice , Lombardi Valeria , Biscosi Francesca , Barile Elena , Dibenedetto Gioacchino , Papagni Giuseppe , Tortora Nicola , Bolgeo Tatiana , Dicuonzo Vincenzo , Parozzi Mauro , Ferrara Paolo , Stefano Terzoni , Gjini Enkeleda
Published: May 2024

BACKGROUND: University nursing tutoring from clinical nurses is an essential and necessary component in supporting students to be successful in curricular activities in support of classroom learning. The aim of this study was to describe the experience of the nurse involved in clinical tutoring of students in the Bachelor of Science in Nursing course at an Italian university.
 METHODS: A survey questionnaire created on the basis of a literature review was sent to all nurses involved in clinical tutoring within the ASL Bt.
RESULTS: 67.44% reported that they had never received any kind of specific training despite the fact that 92.51% considered it essential for the correct performance of the role. 82.13% believe that this activity is not adequately valued
CONCLUSIONS: The results obtained represent beginning of an educational pathway aimed at standardising the training processes of the clinical tutor, oriented towards improving the learning pathway of the future nursing class.
FREQUENCY OF EARLY STENT THROMBOSIS (ACUTE AND SUBACUTE) IN PATIENTS PRESENTING WITH ACUTE ST ELEVATION MYOCARDIAL INFARCTION (STEMI) UNDERGOING PRIMARY PERCUTANEOUS CORONARY INTERVENTION (PCI)
Authors: KHAN AU , ZEB H , ULLAH S , KHAN A , AFZAL Z
Published: May 2024

Sudden cardiac stent thrombosis (ST) is a severe clinical risk that can lead to high fatality rates. However, data are scarce on the prevalence of early ST events following ‘primary percutaneous coronary intervention’ (pPCI) and the characteristics that predict it, particularly among Pakistani patients. Objective: The objective is to determine possible indicators and evaluate ‘the frequency of acute and sub-acute stent thrombosis’ (ST) after ‘primary percutaneous coronary intervention’ (PCI). Methods: Five hundred individuals who had undergone primary PCI were enrolled from July 2022 to December 2023. Telephone follow-up assessments were used to gather information on 30-day results, including death rates, recurrence of symptoms, and episodes of ST. ‘ST was classified as acute’ (occurring ‘during the procedure’) or ‘sub-acute’ (‘occurring within 30 days post-procedure) using standardised criteria established by the ‘Academic Research Consortium. Results:  In this study, 500 patients were enrolled, primarily male (80.4%, 362 patients). ‘Stent thrombosis’ (either acute or sub-acute) was observed in 6.8% of patients, with 10.1% (4) classified as definite ST and the remaining 91.9% (34) as probable ST. Male patients were more prevalent among those who developed ST, along with a higher incidence of hypertension, diabetes, reduced left ventricular ejection fraction (LVEF) pre-PCI, and higher Killip Class. Patients with ST experienced a higher in-hospital mortality rate compared to those without ST, with a p-value of 0.02. Notably, ‘Killip Class’ (‘III-IV’) emerged as ‘an independent ST predictor in this patient cohort. These findings underscore the importance of risk assessment and vigilant management, particularly in patients presenting with higher Killip Class and other associated risk factors, to mitigate ST occurrence and adverse outcomes following primary PCI. Conclusion: Early stent thrombosis (ST) appears relatively common in patients undergoing primary PCI. Those with diabetes and hypertension face an elevated risk of ST, while patients presenting in ‘Killip Class III-IV’ demonstrate an ‘independent predictive’ factor for early ST.