bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Elektroda Pasta Karbon termodifikasi Molecularly Imprinted Polymer sebagai Sensor Potensiometri Asam Urat
Authors: Khasanah Mirartul , Darmokoesoemo Handoko , Widayanti Nesti
Published: December 2017

ABSTRAK            Pengembangan elektroda pasta karbon/molecularly imprinted polymer (MIP) sebagai sensor untuk analisis asam urat secara potensiometri telah dilakukan. MIP dibuat dari monomer metil metakrilat, cross-linker etilen glikol dimetakrilat, dan asam urat sebagai template. Elektroda yang memberikan kinerja optimum dibuat dengan komposisi karbon, MIP, dan parafin 40:25:35(%b/b). Pengukuran larutan asam urat dilakukan pada pH optimum 5. Kinerja elektroda dinyatakan dengan nilai faktor Nernst sebesar 30,19 mV/dekade dengan jangkauan pengukuran 10-6-10-3 M, koefisien variasi 1,36-2,03%, akurasi 63,9-166,0 % dan batas deteksi bawah sebesar 3,03x10-6 M. Pengukuran asam urat dengan elektroda ini tidak diganggu oleh keberadaan urea yang ditunjukkan dengan nilai koefisien selektivitas (Kij) kurang dari satu. Elektroda ini memiliki waktu respon kurang dari dua menit dan waktu hidup selama delapan minggu dengan 104 kali pemakaian. Kata kunci: elektroda pasta karbon, MIP, potensiometri, asam urat ABSTRACTCarbon paste electrode modified molecularly imprinted polymer (MIP) as a sensor to analyze uric acid by potentiometry has been developed. MIP was synthesized by mixing methyl methacrylate as monomer, etylene glycol dimethacrylic acid as cross-linker, and uric acid as template. The electrode which showed the best performance was manufactured by ratio of carbon, MIP, and paraffin of 40:25:35 (w/w). The developed electrode showed the optimum performance on the uric acid pH 5. The performances of carbon paste/MIP electrode was expressed by Nernst factor of 30.19 mV/decade, measurement range of 10-6-10-3 M, the coefficient of variation (CV) of 1.36-2.03% and accuracy of 63.9-166.0%. The detection limit of this method was 3.03x10-6 M. Analysis of uric acid using the electrode was not interfered by urea. The developed electrode showed the response time less than 2 minutes, while lifetime of the electrode was 8 weeks (104 times usage). Keyword : carbon paste electrode, MIP, potentiometry, uric acid
ISOLATION OF BIOACTIVE COMPOUNDS FROM DICRANACEAE MOSSES
Authors: Junairiah Junairiah , Nurhariyati Tri , Ni'matuzahroh Ni'matuzahroh , Sulistyorini Lilis
Published: December 2017

ABSTRACT            Dicranoloma reflexum and Dicranella coarctata are mosses from Dicranaceae family. This study was purposed to identify bioactive compounds contained from both species. Dicranoloma reflexum and Dicranella coarctata collected form Cangar forest, Batu, East Java. Mosses was rinsed, dried and crushed into powder. Extraction was performed using maceration method with n-hexane, acetic acid, and methanol solvent. Compounds obtained then identified using Gass Chromatography Mass Spectra. Result showed that n-hexane, acetic ethyl, and methanol extract of Dicranoloma reflexum contained 61, 16, and 58 compounds respectively. Main component of each extract was 1-octadecene, phenol, and 9-octadecanoic acid. N-hexane, acetic ethyl, and methanol extract of Dicranella coarctata contained 5, 38, and 23 compounds respectively. Main component of each extract was thiosulphuric acid, E-15 heptedecenal, and n-hexadecanoic acid.Key words : Dicranaceae, bioactive compounds
Skopoletin Senyawa Fenilpropanoid dari Kulit Umbi Ubi Jalar (Ipomoea batatas L.) varietas IR-melati
Authors: Pramitha Citra Putri , Aminah Nanik Siti , Kristanti Alfinda Novi
Published: December 2017

AbstrakTelah berhasil diisolasi senyawa golongan fenilpropanoid dengan nama “skopoletin” dari kulit umbi ubi jalar (Ipomoea batatas L.). Ekstraksi senyawa dilakukan dengan metode maserasi menggunakan pelarut metanol, dilanjutkan dengan partisi menggunakan n-heksana dan etil asetat. Pemisahan dan pemurnian senyawa dilakukan menggunakan teknik kromatografi kolom gravitasi. Struktur senyawa dianalisis berdasarkan data spektroskopi UV/Vis, 1D, dan 2D-NMR. Kata kunci : fenilpropanoid, skopoletin, Ipomoea batatas L. AbstractIt has been isolated phenylpropanoid group compound named scopoletin from the tuber peel of Ipomoea batatas L. Extraction of this compound was done by maceration method using methanol solvent, followed by partition with n-hexane and ethyl acetate. Separation and purofication of compound was done by gravity column chromatography techniques. Structure of compound was analyzed by UV/Vis, 1D and 2D NMR spectroscopies. Keywords : phenylpropanoid, scopoletin, Ipomoea batatas L.
ADSORPSI METILEN BIRU PADA ABU LAYANG (FLY ASH) HASIL PEMBAKARAN CANGKANG SAWIT PADA BOILER PABRIK KELAPA SAWIT
Authors: Triawan Deni Agus
Published: December 2017

Telah dilakukan penelitian adsorpsi metilen biru pada adsorben abu layang (fly ash) hasil pembakaran cangkang sawit pada boiler. Adsorben abu layang terlebih dahulu dipersiapkan dengan aktivasi kimia menggunakan H3PO4 10% dan tanpa aktivasi sebagai pembanding. Hasil penelitian menunjukkan bahwa adsorpsi metilen biru pada abu layang tanpa aktivasi maupun dengan aktivasi  mengikuti model kinetika orde dua semu menurut Ho dengan nilai R2 sebesar 0,990 untuk adsorben tanpa aktivasi dan 0,996 untuk adsorben dengan aktivasi. Isotherm adsorpsi zat warna metilen biru pada abu layang mengikuti model isotherm menurut Freundlich dengan nilai R2 sebesar 0,988 (kapasitas adsorpsi 19,81 mg/g) untuk abu layang tanpa aktivasi dan sebesar 0,991 (kapasitas adsorpsi 60,11 mg/g) untuk abu layang dengan aktivasi.
Isolasi dan Identifikasi Minyak Atsiri dari Biji Tanaman Kapulaga (AmomumcaedamomumWilld)
Authors: Tambunan Lilis Rosmaniar
Published: December 2017

Minyak atsiri disebut juga minyak eterisatau minyak yang mudah menguap banyak diperlukan dalam kehidupan sehari-hari, memilikisifatmudahmenguap, berbau khas sesuai dengan bau tanaman penghasilnya, getir, memabukkan, larut dalam larutan organic namun tidat larut dalam air. Minyak atsiri dihasilkandari bagian jaringan tanaman tertentu seperti akar, batang, kulit, daun, bunga, buah, ataubiji.Tanaman kapulaga (AmomumCardamomum) telah lama diusahakan dibeberapa daerah Indonesia. Kapulaga selama ini dikenal sebagai rempah untuk masakan.Biji kapulaga yang diambil dari tumbuhan sebelum buah masak benar dapat dimanfaatkan sebagai obat. Biji kapulaga mengandung terpineol, terpineolasetat, sineol, borneol, dankamfer yang berkhasiat mengencerkan dahak, memudahkan pengeluaran air dari perut, menghangatkan, membersihkandarah, menghilangkan rasa sakir, mengharumkan, stimulandanpemberi aroma.Penelitian ini bertujuan untuk mengetahui kandungan yang terkandung dalam minyak atsiri Biji Kapulaga dengan cara mengisolasi biji Kapulaga dengan menggunakan destilasi uap dan air. Rendemen minyakatsiri yang diperolehsebesar 0,76 % dan kemudian di identifikasi dengan menggunakan Spektroskopi IRdan GC-MS sehingga diperoleh senyawa alpha pinen, sabinen, beta pinen, sineol, 3-sikloheksen-1-metanol, 12-kloro-bisiklo, 9-oktadekenal, 9,12-asam oktadekadienoat, metil ester dari asam risinoleat, 4H-siklopentasiklookten-4-on.Kata kunci : kapulaga, amomumcardamomum, sineol
Monitoring of Structures by a Laser Pointer. Dynamic Measurement of Rotations and Displacements of the Elastic Line of a Bridge: Methodology and First Test
Authors: Artese Serena , Achilli Vladimiro , Zinno Raffaele
Published: December 2017

Deck inclination and vertical displacements are among the most important technical parameters to evaluate the health status of a bridge and to verify its bearing capacity. Several methods, both conventional and innovative, are used for structural rotations and displacement monitoring; no one of these does allow, at the same time, precision, automation, static and dynamic monitoring without using high cost instrumentation. The proposed system uses a common laser pointer and image processing. The elastic line inclination is measured by analyzing the single frames of a HD video of the laser beam imprint projected on a flat target. For the image processing, a code was developed in Matlab® that provides instantaneous rotation and displacement of a bridge, charged by a mobile load. An important feature is the synchronization of the load positioning, obtained by a GNSS receiver or by a video. After the calibration procedures, a test was carried out during the movements of a heavy truck maneuvering on a bridge. Data acquisition synchronization allowed to relate the position of the truck on the deck to inclination and displacements. The inclination of elastic line was obtained with a precision of 0.01 mrad. The results demonstrate the suitability of the method for dynamic load tests, control and monitoring of bridges.
Effect of a Gurney Flap on the Performance of an Axial Fan
Authors: Liu Chen , Xie Haijun , Xu Jun , Jian Chen , Dai Ren
Published: December 2017

The Gurney flap (GF) is a miniature lift-enhancement device and is usually mounted at the trailing edge of an airfoil. The GF and has been successfully applied to isolated airfoils, multi-element airfoils, and aircraft wings as well as helicopter rotor due to its attractive features of simplicity, cost-effective and separation control. The GF also has aroused the attention of researchers in the turbomachinery industry. However, limited studies are currently available on the application of a GF to an axial fan.Hence, in this paper, we conduct a wind tunnel and computational fluid dynamic (CFD) investigation on an axial fan profiled with a NACA 65-(12)10 airfoil to evaluate the effect of the GF on the performance of the fan. We also present the detailed flow features of the fan with and without the GF after validating the simulation results with the experimental results. The experimental results show that as the GF is installed higher on the fan blade, it can produce a higher total pressure rise accompanied with a greater loss of efficiency. The installation of the GF also enlarges the work capacity of the fan. Detailed flow field analysis, including the surface pressure distribution, vorticity distribution at the trailing edge and streamline distribution of the fan, is carried out to understand the mechanisms of the effect of the GF on the performance of the fan.
Intervenção fisioterapêutica na Síndrome da Imobilidade em pessoas idosas: revisão sistematizada
Authors: Pereira Hellen Cristina Barbosa , Duarte Paulo Henrique Meira , Mélo Thaynara do Monte , Silva Rielly Maria Cruz da , Santos Wagner Vitória dos , Barbosa Daniella de Souza , Nóbrega Rafaella Gerbasi , Veloso Laura de Sousa Gomes
Published: December 2017

O envelhecimento é um estado comum na qual todo idoso irá vivenciar, no entanto envelhecer não é apenas um estado, e sim um processo que o corpo viverá. Como consequência a saúde do idoso é marcada pelo desempenho proporcional de quatro esferas funcionais: cognição, humor, mobilidade e comunicação. Com isso o presente estudo tem por objetivo conhecer as atuais tendências da produção cientifica nacional e internacional sobre a intervenção fisioterapêutica na síndrome da imobilidade em pessoas idosas. Material e método: Para tal foi realizado estudo de revisão de literatura, fundamentada em livros e ensaios científicos publicados sobre a intervenção da fisioterapia na patologia supracitada. Foram analisados 7 estudos, sendo possível observar que a atuação fisioterapêutica na síndrome da imobilidade é extremamente importante, mostrando a eficácia nas respostas negativas que a patologia traz, tendo a cinesioterapia como recurso mais utilizado. Foi constatado ainda que ainda há muito que se investigar sobre essa temática.Descritores: Idoso; Movimento; Síndrome; Fisioterapia.
Qualidade de vida de estudantes de graduação e pós-graduação em Odontologia
Authors: Amadeu João Rafael , Justi Mirella Martins
Published: December 2017

Segundo a Organização Mundial de Saúde (OMS) a qualidade de vida (QV) pode ser definida como “a percepção do indivíduo de sua posição na vida, no contexto da cultura e sistema de valores nos quais ele vive e em relação aos seus objetivos, expectativas, padrões e preocupações”. Para se mensurar a QV um dos instrumentos utilizados é o questionário WHOQOL-bref, que foi desenvolvido pelo Grupo de Qualidade de Vida da Organização Mundial de Saúde para se avaliar este aspecto de forma rápida e objetiva, sendo ele a versão abreviada do WHOQOL-100. O instrumento consta de 26 questões que abrangem diferentes facetas dentro de quatro domínios diferentes, que são o físico, o psicológico, das relações sociais e o ambiente. O objetivo deste estudo foi a aplicação do WHOQOL-Bref em uma amostra de 150 estudantes de graduação e pós-graduação de uma Faculdade de Odontologia de uma universidade pública do Estado de São Paulo com a finalidade de avaliar a qualidade de vida dos estudantes em vários quesitos socioeconômicos. A média geral da qualidade de vida dos estudantes foi de 62,4. O domínio com melhor avaliação foi o das Relações Sociais (69,3), seguido pelo Psicológico (64,3) e Ambiente (64,0), sendo o Domínio Físico (51,7) o pior avaliado. Por meio deste estudo foi possível a identificação dos pontos pertinentes da qualidade de vida dos estudantes de Odontologia, percebendo muitas das dificuldades vivenciadas no dia a dia e que afetam diretamente este aspecto, além de também buscar traçar algumas estratégias que contribuam para sua melhoria.Descritores: Qualidade de Vida; Odontologia; Educação Superior.
Nanotechnology in Dentistry
Authors: Arruda José Alcides Almeida de , Oliveira Cinthia Figueiredo de , Paula Carina Silva de , Mosqueira Vanessa Carla Furtado , Moreno Amália , Mesquita Ricardo Alves
Published: December 2017

Introduction: Nanotechnology is a rapidly expanding field that encompasses the development, manipulation, and application of structures on the nanometer scale. Applications of nanotechnology to dentistry are particularly promising and comprise materials and devices designed to achieve maximal therapeutic efficacy with minimal side effects. Objective: This review discusses the advantages of nanotechnology and the different types of nanostructures used in dentistry. Material and Method: In this study, online databases: pubmed, medline and scielo were searched to analyse the current understanding of the potential of nanotechnology in dentistry, including the restoration of tooth structure with nanocomposites and the development of nanoparticles for dentin remineralisation, drug delivery, disease diagnostics, oral analgesia, oral hygiene maintenance, local anaesthesia, tooth desensitisation, and bone tissue repair. Results: The study demonstrated a wide range of nanotechnological strategies in different dentistry areas and suggests that nanotechnology-based delivery systems may be very useful to improve treatment, prevention and repair in dentistry in the future. Conclusion: There is little or no clinical experience for the nanotechnology-based drug delivery systems cited herein. Safety assessments and clinical trials are the next step in their development.Descriptors: Nanotechnology; Dental Research; Biocompatible Materials.
Eternit fibrocementinės plokštės antigrafitinės dangos tyrimo rezultatų analizė
Authors: Urbonas Mantas , Kelpšienė Loreta
Published: December 2017

Straipsnyje analizuojami fibrocementinių plokščių antigrafitiės dangos atsparumo valymui tyrimo rezultatai. Buvo dirbama dviem būdais: bandymai atlikti fiksuotoje ir kintančioje vietose. Tirtos plokštės padengtos cheminiam poveikiui atspariu paviršiumi, bandinių matmenys – 20 × 30 cm. Tyrimui buvo naudojami 2 grafičių valikliai: Rasant 031 ir Arrow-Plan. Po bandymo įvertintas grafičių dažų nusivalymo lygis ir pradinės gaminio spalvos išlikimo (nepažeistumo) lygis. Tyrimas parodė, kad sunkiausiai besivalanti spalva yra Daž3. Didžiausi pradinės gaminio spalvos pažeidimai po valymo taip pat būdingi šia spalva apipurkštoms vietoms. Tirta antigrafitinė danga atspari valymui su Rasant 031 ir Arrow-Plan, bet Daž3 spalvos grafičių dažams valyti reikia ieškoti kitų priemonių.
Šv. Bazilijaus Didžiojo Ordinas XVIII a. pabaigoje–1830 metais
Authors: Salamacha Mychailas
Published: December 2017

Straipsnyje apžvelgiamas šv. Bazilijaus Didžiojo ordino (OSBM) struktūrinis pertvarkymas XVIII a. paskutiniame trečdalyje. Struktūriniai pokyčiai tapo pagrindu, kuriantis naujoms šv. Bazilijaus Didžiojo ordino provincijoms. Pokyčius lėmė Lietuvos – Lenkijos Respublikos (Žečpospolitos) padalijimai ir šv. Bazilijaus Didžiojo ordino teritorijos pasidalijimas tarp Austrijos ir Rusijos imperijų. Straipsnyje pateikiama šv. Bazilijaus Didžiojo ordino vienuolynų skaičiaus kaita bei pačių vienuolių mažėjimas dėl imperatoriškųjų valstybių politikos. Galutinai bazilijonų vienuolynus, kaip neatitinkančius stačiatikių bažnytinės politikos, Romanovų dinastija likvidavo XIX a. 3-me dešimtmetyje.
Supply and Transport Limitations on Phosphorus Losses from Agricultural Fields in the Lower Great Lakes Region, Canada
Authors: Plach Janina M. , Macrae Merrin L. , Ali Genevieve A. , Brunke Richard R. , English Michael C. , Ferguson Gabrielle , Lam W. Vito , Lozier Tatianna M. , McKague Kevin , O'Halloran Ivan P. , Opolko Gilian , Van Esbroeck Christopher J.
Published: December 2017

Phosphorus (P) mobilization in agricultural landscapes is regulated by both hydrologic (transport) and biogeochemical (supply) processes interacting within soils; however, the dominance of these controls can vary spatially and temporally. In this study, we analyzed a 5‐yr dataset of stormflow events across nine agricultural fields in the lower Great Lakes region of Ontario, Canada, to determine if edge‐of‐field surface runoff and tile drainage losses (total and dissolved reactive P) were limited by transport mechanisms or P supply. Field sites ranged from clay loam, silt loam, to sandy loam textures. Findings indicate that biogeochemical processes (P supply) were more important for tile drain P loading patterns (i.e., variable flow‐weighted mean concentrations ([Cf]) across a range of flow regimes) relative to surface runoff, which trended toward a more chemostatic or transport‐limited response. At two sites with the same soil texture, higher tile [Cf] and greater transport limitations were apparent at the site with higher soil available P (STP); however, STP did not significantly correlate with tile [Cf] or P loading patterns across the nine sites. This may reflect that the fields were all within a narrow STP range and were not elevated in STP concentrations (Olsen‐P, ≤25 mg kg−1). For the study sites where STP was maintained at reasonable concentrations, hydrology was less of a driving factor for tile P loadings, and thus management strategies that limit P supply may be an effective way to reduce P losses from fields (e.g., timing of fertilizer application).

Core Ideas

We used metrics to evaluate controls on edge‐of‐field phosphorus losses.

We examined a 5‐yr database of stormflow events (all seasons, including winter).

Tile P runoff trended toward being more supply limited than surface runoff.
Review: Sediment‐Related Controls on the Health of the Great Barrier Reef
Authors: Hairsine Peter B.
Published: December 2017

Core Ideas

Linking terrestrial soil erosion to marine ecosystem degradation relies on a long chain of evidence.

Excess terrestrial erosion impacts marine ecosystems via changes to marine food webs.

A graphic summary of the spatial configuration of the sources and sinks is provided.

Increased management of near‐coastal sediment sources and terrestrial sediment sinks is appropriate.

Research needs include techniques for enhancing sediment trapping, response times, and nutrient tracking.

Linking terrestrial soil erosion to the degradation of marine ecosystems relies on a long chain of evidence. Here, this chain of evidence is reviewed for Australia's Great Barrier Reef and its catchments. Excessive sediment delivery to the marine environment is one component of an interlinked group of stressors that include coral bleaching, damage by storms, and plagues of crown‐of‐thorns starfish. Sediment and the pollutants they carry are one of the drivers of marine ecosystem decline and adversely impact recovery following disturbance by other stressors. Significantly, a portion of the N species carried by fine sediment in the freshwater system is released in the marine environment, thereby perturbing marine ecology. Available controls on sediment and pollutant delivery are hillslope erosion rates, gully and streambank erosion rates, sediment deposition rates in sediment sinks including footslopes, floodplains, and water reservoirs, and the application rates of pesticides and fertilizers. By reducing sediment fluxes through the combined strategies of erosion control and deposition enhancement, near‐ and offshore impacts can be reduced. Gully and streambank erosion are more significant sources of fine sediment than hillslope erosion. Fertilizer and non‐fertilizer N and pesticides carried by sediment play an important role in coral reef degradation. A graphic summary of the spatial configuration the sources and sinks is provided to guide the prioritization of interventions. The scale of intervention required to achieve the desired marine outcome is so large that a combined voluntary and regulatory approach is needed.
Comparing Two Applicative Criteria of the Soil Erosion Physical Model Concept
Authors: Bagarello Vincenzo , Ferro Vito , Pampalone Vincenzo
Published: December 2017

Core Ideas

The physical model concept allows testing of the reliability of soil loss predictions.

This concept was applied by using the original and a new criterion in southern Italy.

The new criterion was generally more restrictive than the original one.

The physical model represented by a replicated plot has been suggested to be the best possible, unbiased, real world model to predict plot soil erosion. The aim of this investigation was to compare the original applicative criterion of the physical model concept proposed by Nearing with that later suggested by Bagarello et al. The comparison was performed by using three empirical soil erosion models (the Universal Soil Loss Equation [USLE], a modified USLE [USLE‐MM], and the Central and Southern Italy [CSI] model) and plot soil loss data collected at the experimental station of Sparacia, in Sicily (southern Italy). The investigation showed that (i) the new criterion was generally more restrictive, i.e., less prone to accept the similarity hypothesis between predictions and measurements, than the original one; (ii) the new criterion gave a similar number of acceptable predictions as the original one when absolute differences between measured and predicted soil losses by the replicated plot were associated with a frequency occurrence factor of 0.87; (iii) for both tested criteria, the percentage of acceptable predictions could be considered time independent, and consequently, the checked performances of the three soil loss models could be considered generally representative of their capability in predicting soil losses at the sampled site; (iv) with the exception of the calibrated USLE, the hypothesis that, according to the original criterion, an effectiveness coefficient greater and lower than 0.6 could be expected for a calibrated and uncalibrated model, respectively, was confirmed; and (v) the new criterion allowed establishment of an effectiveness coefficient of 0.12, which discriminates between uncalibrated and calibrated models.
Identifikasi Tantangan Adopsi E-commerce Pada Rumah Produksi Seulanga
Authors: Juwita Juwita , Risa Nursanty , Heru Fahlevi
Published: December 2017

Peukan Bada is one of districts in Aceh Besar which directly opposite to Indian Ocean. This district had abundant marine fishery resources. In 2016  Seulanga home production has implemented E-commerce website to support their sales and promotion process, but after six months of releasing, there were no transcations occured. Fourth stage of  E-commerce adoption in small and medium bussiness were achieved, if online transactions including ordering and payment have occured. To achieved that a reliable e-commerce website and organizational readiness was needed.The objective of this study was to  identify the challenge of E-commerce adoption in Seulanga home production. It used Fishbone cause and effect with  4P  approach (Price, Product, Place and Promotion). Data collecting using focus group discussion and site search testing technic. This research taken place in Peukan Bada district, Exactly in Lamteungoh village. This research had successfully identified causes that challenge the E-commerce adoption in seulanga home production, those were : product were unregistered, the fluctuative price, no managerial skilled staf and IT skilled staff, no promotion strategy applied and unsmart site search features. All those factors become barries of E-commerce adoption for seulanga home production, so Seulanga need external intervention to cope their continuity in bussiness
Layanan Berbasis Lokasi Hotel Menggunakan Realitas Tertambah
Authors: Imansyah Nur , Widiastuti Sri Handani
Published: December 2017

Getting information in real time at specific times and locations is especially needed when users have high mobility. But often users are not familiar with the area, so difficulty in finding locations and information. The development of technology for location based services and augmented reality makes it easy to get information from available resources in locations using mobile devices equipped with GPS devices. The research aims to combine hotel location based services and augmented reality in android-based mobile device by manipulating virtual objects into real objects through the camera as input and mobile phone display as output.The integration of hotel location based services and augmented reality is useful for hotel users to be able to search hotel information by directing the camera mobile device in the direction of specific targets to be retrieved information. The output of the system is provided in real time on the mobile device display for the user. Output information provided in the direction of location of the hotel object and information about the object of the hotel.
Manajemen Kualitas Data dan Informasi Berbantuan Sistem Informasi untuk Meningkatkan Kinerja Operasional Pabrik Pengolahan Kelapa Wawit
Authors: Karami Ahmad Fahmi
Published: December 2017

Organizational performance depends on strategic decisions taken by stakeholders in the organization, where strategic decisions of stakeholders depend on the quality of data and information available to the organization. Data and information quality called good when the data and quality has criteria that suits for users of data and information, where data and information user need on the organization will be different according to their aim and objectives, so that the criteria of data quality and information is not universal. The research aims to improve the quality management of data and information by utilizing information systems to produce good quality data and information and help improve the organization's performance on the Palm Oil Processing Factory in Indonesia. This research was conducted to know data and information quality management in producing data and information, and its contribution on the mill performance using interview methods with those who have a role in the implementation of data quality and information management, observation, and document management related to factory performance. This research resulted findings that still in the implementation of data quality and information management there are still procedures that are not undertaken, so the result of data and information not entirely suits with the user wishes. Although the procedure has not been fully implemented, using data and information production has helped data and information users in decision making and succeeded in lowering the mill breakdown by 0.10%.
Adhesive Drug Delivery Systems Based on Polyelectrolyte Complex Nanoparticles (PEC NP) for Bone Healing
Authors: Muller Martin , Vehlow David , Torger Bernhard , Urban Birgit , Woltmann Beatrice , Hempel Ute
Published: December 2017

Background:

In this contribution an overview is given on own work concerning drug loaded Polyelectrolyte
Complex (PEC) Nanoparticles (NP) used to functionalize Bone Substitute Materials (BSM) for the therapy
of bone defects associated with systemic bone diseases. In this context, drug loaded PEC NP have certain advantages,
which are exemplarily summarized herein.

Methods:

Concerning preparative methods PEC NP were fabricated by controlled mixing of polycation and polyanion
solutions and integration of charged drugs during and after mixing. Control was taken on the stoichiometric
ratio related to cationic and anionic repeating units, which was chosen close to zero for the final applied PEC NP.
Concerning analytical methods a couple of physical-chemical methods were applied like colloid titration, Dynamic
Light Scattering (DLS), Scanning Force Microscopy (SFM), Fourier Transform infrared (FTIR) spectroscopy,
Ultraviolet-Visible (UV-VIS) and Circular Dichroism (CD) spectroscopy to characterize colloid stability,
adhesiveness, drug loading and release of PEC NP. Moreover, standard biochemical and microbiological assays
were applied.

Conclusion:

Drug loaded PEC NP consist of oppositely charged biorelated Polyelectrolytes (PEL) like ionic
polysaccharides or ionic polypeptides and also synthetic PEL, which are mixed and processed in aqueous media.
At first, freshly prepared drug/PEC NP exhibit time dependent colloidal stability in the range of weeks and
months, which enables and simplifies storage, transport and application in the medical field. Secondly, after
deposition and drying of drug/PEC NP a local wet adhesive PEC matrix at the BSM remains in contact to relevant
aqueous media (e.g. buffer, cell culture medium), which minimizes asepsis, systemic toxicity, immune or inflammatory
reaction. Thirdly, cell compatible PEC NP coatings were identified, which showed only minimal
effects on various relevant bone related cells due to biorelateness, complexation, local confinement and low surface
area. Fourthly, PEC NP elute drugs for bone healing like bisphosphonates, antibiotics and growth factors
(e.g. bone morphogenetic proteins) in delayed and sustained manner. Moreover, the onset of elution could be
triggered by thermoresponsive PEL via temperature increase giving clinicians a tool into hand allowing spatiotemporal
drug release on demand. Finally, drug/PEC NP could be integrated into commercial or still developed
allotropic stabilizing or defect filling BSM systems.
Substrates for Paraoxonase
Authors: Mu Xiaojing , Yi Xiaoqi , Xiao Shangyou , Wang Chengshan , Chen Gang , Li Yan
Published: December 2017

Background:

Paraoxonase (PON) is a family of calcium-dependent hydrolases, which is related to
many diseases. Elucidation of PON physiological roles, active center and all applications in medical fields are
dependent on its substrates.

Objective:

The reports about PON substrates scattered in a long span of period are collected to afford clue for
drug design, diagnosis of PON status and other academic purposes.

Method:

PON substrates from 133 references are classified and compared. Structurally, PON substrates are generally
classified as organic phosphorous esters, lactones and arylesters. Some phosphoramidates, organophosphorous
obidoximes, aryl carboxylic acid amides and special fatty alcohol esters as PON substrates are also included.

Results:

The electron nature, steric hindrance and hydrophilicity of substrate substituents affecting the PON catalytic
ability, binding ability and specificities are discussed. Drugs, prodrugs and naturally endogenous molecules
in life processes activated or inactivate by PON are reviewed. Interestingly, some organophosphate and lactone
substrates are preferably hydrolyzed by one of the PON1R192Q allozymes, and such a substrate is generally essential
for differentiating the three PON1192R phenotypes by using a dual-substrate method. Intricately, some chiral
substrates are hydrolyzed by PON stereoselectively.

Conclusion:

As more substrates are synthesized and characterized, more facts about PON structure and catalytic
properties (including PON active center and catalytic mechanism) will be revealed, and therefore the use of PON
as a drug target or as an accurate disease marker will be achieved.
Genetic Variability of SRC Family Kinases and Its Association with Platelet Hyperreactivity and Clinical Outcomes: A Systematic Review
Authors: Milanowski Lukasz , Rasul Fazila , Gajda Sylwia Natalia , Eyileten Ceren , Siller-Matula Jolanta , Postula Marek
Published: December 2017

Background:

Platelet hyperactivity has been implicated in many cardiovascular (CV) events such as
ischemic stroke, myocardial infarction and CV death. Genetic variability of platelet receptors has been shown to
impact Src family kinases (SFKs) activation and in turn influence platelet activation. SFKs are important signal
transmitters in platelets, interacting with several receptors as GPIIB/IIIa, GPIb, PEAR 1, GPIa, GPVI, PECAM
and CD148.

Methods:

In this review, we focused on genetic variants of platelet receptors whose signals are transmitted
mainly by SFKs and may be associated with clinical manifestations of platelet hyperactivation like MI or IS.

Results:

The genetic variants of platelet receptors, the signals of which are transmitted by SFKs, and the associated
clinical manifestations in platelet hyperactivation, have been examined. The most extensively studied receptors
were glycoprotein polymorphisms. The greatest numbers of genetic variants were analyzed in GPIb.
GPIIb/IIIa receptor polymorphisms were also well analyzed and many studies highlighted their associations with
ischemic stroke (IS) and myocardial infarction (MI). However, there are a number of conflicting studies finding
that GPIIb/IIIa receptor polymorphisms may not influence platelet hyperactivity. Moreover, variability within
some other receptors like GPVI, PECAM, PEAR1, and CD148 was analyzed only in single studies.

Conclusions:

Src family kinases are one of the most important signal transmitters in platelets. Some receptors
have well documented interactions with SFKs, while other have not been examined in humans or data about its
association originated from single studies. Further studies are necessary to confirm the findings and reduce falsepositive
associations.
Chemosensitizing Activity of Histone Deacetylases Inhibitory Cyclic Hydroxamic Acids for Combination Chemotherapy of Lymphatic Leukemia
Authors: Mishchenko Denis V. , Neganova Margarita E. , Klimanova Elena N. , Sashenkova Tatyana E. , Klochkov Sergey G. , Shevtsova Elena F. , Vystorop Igor V. , Tarasov Vadim V. , Chubarev Vladimir N. , Samsonova Anna N. , Ashraf Ghulam Md , Barreto George , Yarla Nagendra Sastry , Aliev Gjumrakch
Published: December 2017

Background:

Anti-tumor effect of hydroxamic acid derivatives is largely connected with
its properties as efficient inhibitors of histone deacetylases, and other metalloenzymes involved in
carcinogenesis.

Objective:

The work was aimed to (i) determine the anti-tumor and chemosensitizing activity of the
novel racemic spirocyclic hydroxamic acids using experimental drug sensitive leukemia P388 of mice,
and (ii) determine the structure-activity relationships as metal chelating and HDAC inhibitory agents.

Method:

Outbreed male rat of 200-220 g weights were used in biochemical experiments. In vivo
experiments were performed using the BDF1 hybrid male mice of 22-24 g weight. Lipid peroxidation,
Fe (II) -chelating activity, HDAC fluorescent activity, anti-tumor and anti-metastatic activity,
acute toxicity techniques were used in this study.

Results:

Chemosensitizing properties of water soluble cyclic hydroxamic acids (CHA) are evaluated
using in vitro activities and in vivo methods and found significant results. These compounds possess
iron (II) chelating properties, and slightly inhibit lipid peroxidation. CHA prepared from triacetonamine
(1a-e) are more effective Fe (II) ions cheaters, as compared to CHA prepared from 1-
methylpiperidone (2a-e). The histone deacetylase (HDAC) inhibitory activity, lipophilicity and acute
toxicity were influenced by the length amino acids (size) (Glycine < Alanine < Valine < Leucine
< Phenylalanine). All compounds bearing spiro-N-methylpiperidine ring (2a-e) are non-toxic up to
1250 mg/kg dose, while compounds bearing spiro-tetramethylpiperidine ring (1a-e) exhibit moderate
toxicity which increases with increasing lipophility, but not excite at 400 mg/kg.

Conclusion:

It was shown that the use of combination of non-toxic doses of cisplatin (cPt) or cyclophosphamide
with CHA in most cases result in the appearance of a considerable anti-tumor effect of
cytostatics. The highest chemosensitizing activity with respect to leukemia Р388 is demonstrated by
the CHA derivatives of Valine 1c or 2c.
The Effect of Flubendazole on Adhesion and Migration in SW480 and SW620 Colon Cancer Cells
Authors: Hanušová Veronika , Skálová Lenka , Králová Věra , Matoušková Petra
Published: December 2017

Background:

Colon cancer is the most common type of gastrointestinal cancer. Despite advances
during the last two decades, the efficacy of colorectal cancer treatment is still insufficient and new anticancer
agents are necessary.

Methods:

In our study, colon cancer cells derived from a primary tumor (SW480) and lymph node metastasis
(SW620) from the same patient were used and compared. The effect of flubendazole (FLU) on cell adhesion and
migration was monitored using the x-CELLigence Real-Time Cell Analysis system. Expressions of molecules involved
in adhesion and migration were analyzed using RT-PCR and western blot. Furthermore, RNA silencing of
nuclear factor-κB in SW620 cells was used to determine the involvement of the NF-κB p65 regulation pathway
in FLU action.

Results:

FLU significantly suppressed the adhesion of SW480 cells and reduced the expression of adhesion
markers (ICAM-1, αE-catenin; β-catenin; integrin α5 and β1). Moreover, a significant anti-migratory potential
of FLU was manifested in the SW620 cells. In addition, FLU suppressed the phosphorylation of NF-κB p65 and
potentiated the suppression of several metastatic markers (ICAM-1, EpCAM, integrin α5, β1, α-tubulin) caused
by NF-κB p65 silencing.

Conclusion:

FLU has a significant anti-migratory effect in intestinal cancer cell SW480 and its lymph node
metastatic cells SW620. FLU decreases the expression of some proteins involved in metastatic processes and
inhibits activation of NF-κB p65.
A Conceptual Framework in the Formation of Young Entrepreneurs in Indonesia
Authors: Rahmatiah Rahmatiah , Wiroto Dondick Wicaksono , Taan Hapsawati
Published: December 2017

This article is an initial step to reach a conceptual understanding on young entrepreneurs in sociological studies. Many studies pertaining to entrepreneurship have been found in various discipline of studies, however, nothing of note has been found particularly in connection to the concept of youth. The current reality in Indonesia precisely exhibits multiple entrepreneurship activities targeting young people as organizers and participants. The identity of entrepreneur is constructed by tracing and researching the variety of important concepts observed in various literature (written by economy, sociology, and entrepreneurship experts) concerning entrepreneur action. Entrepreneur identity has 4 dimensions: triggering event, innovation, action strategy of start-up arrangement (as stated in the business plan/model), and entrepreneurship implementation. Entrepreneur identity will be discussed by using multiple data obtained from YouTube in the form of speeches, lectures, and interviews of young entrepreneurs until an understanding is ultimately acquired regarding the identity of young entrepreneurs’ base of action by analyzing their emphasis on what they do as entrepreneurs. The discussion develops further as the identity touches on a more complex social context: social welfare, hence, young entrepreneurs also have the identity of young entrepreneurs’ social movement comprising of three phases: initiation, strategic, and control.
The deterrence theory: A case for enhanced enforcement of directors’ duties
Authors: Akanmidu Oludara
Published: December 2017

This article is concerned with providing a justification for effective enforcement of directors’ duties. It aims to consider whether enforcement of directors’ duties is necessary. It argues that enforcement of directors’ duties is crucial to effective corporate governance. Drawing on the deterrence theory, it argues that there is a clear link between increased enforcement and increased compliance. Enhanced enforcement of directors’ duties is essential for securing compliance; countries, therefore, ought to put in significant effort to develop effective enforcement mechanisms.
Keragaman Genetik Bawang Merah (Allium cepa L.) Berdasarkan Marka Morfologi dan ISSR
Authors: Sari Vebrita , , Miftahudin , Sobir Dan
Published: December 2017

Development of new shallot varieties requires genetic variation of the germplasm. However, information on genetic diversity of local shallot in Indonesia is still lacking. This study was aimed to analyze the genetic diversity of shallot based on morphological characters and ISSR markers for management of genetic resource and breeding program in Indonesia. This study was conducted during October 2014 to September 2015. The 34-shallot genotypes were collected from several regions in Indonesia in the form of the bulb. Twenty four morphological markers and 13 ISSR primers were used in this research. The informative characters to analyze genetic diversity of shallot were foliage cracking, bulb number and bulb morphological characters. ISSR markers generated 103 DNA polymorphic band with the total of 89.57% and the informative primers were ISSRred 4, ISSRred 9 and ISSRred 20. Both morphological and ISSR markers showed 27% genetic diversity and grouped all genotypes into two main groups; however the grouping did not relate to the geographic origin. The largest bulb diameter of 7.54 cm was obtained from Bangkok variety and the highest number of bulb per clump of 27 bulb/clump was produced by the genotype from Pekanbaru. These genotypes can be used as potential parents for shallot breeding program in Indonesia.

Keywords: genetic diversity, ISSR markers, morphological characters, shallot
Keragaan dan Kemampuan Meratun Lima Genotipe Sorgum
Authors: Meliala Merry Gloria , , Trikoesoemaningtyas , Sopandie Dan Didy
Published: December 2017

Ratooning can be used as an alternative cultivation technique for production of sorghum. This study was aimed to evaluate the growth and production of ratoon following the main crop. The study was conducted during August 2013 until November 2014, at Cikabayan Experimental Station, Bogor Agricultural University. The research was arranged in a randomized complete block design with four replications. The results showed that genotypes was significantly affected the vegetative and reproductive characters, physiologycal characters of the main crop, ratooning ability, and vegetative characters of ratoon crop. Plant height, stem diameter, fresh and dry weight, harvest time, and harvest index of main crops had significant correlation with ratooning ability. Plant height, total chlorophyll, fresh and dry weight, panicle weight, grain weight per panicle, 1,000 grain weight, harvest index, and transpiration rate of main crops had significant correlation with ratoon growth. Based on path analysis, the main crop growth directly affected ratoon height, and vegetative characters of ratoon directly affected the yield. The ratoon yielded 48.9-65.7% of the main crop yield.

Keywords: path analysis, ratooning ability, ratoon crops
Karakter Seleksi pada Generasi Awal untuk Adaptasi Padi terhadap Cekaman Suhu Tinggi
Authors: Manalu Victor Manotar Pademan , Wirnas Desta , Sudarsono Dan
Published: December 2017

ABSTRACT

 

           Developing new rice  varieties adaptive to heat stress is important to maintain high rice production in anticipating global warming effects. This research was aimed to find selection characters and to select the best segregant in early generation based on agronomic characters for adaptation of rice to heat stress. The experiment was carried out in September 2014 to Januari 2015. About 210 F2 segregants generated trough hybridization between IPB 4S (sensitive parent) and Situ Patenggang (tolerant parent), 20 individuals of IPB 4S, and 20 individuals of Situ Patenggang, were used as genetic control. All genetic materials were exposed to high temperature stress by growing in a green house of Bogor Agricultural University. The average temperature in the research period was 24 °C and 42.09 °C, respectively for minimum and maximum temperature.  The results showed that charachters of productive and total tiller number, total grain number, and seed weight had high heritability, high coeffiecient of genetics variability-with an additive gene action. That charachters could be proposed as selection criteria in early generation for rice breeding of adaptation to high temperature stress. The characters could be applied  in either single trait or multiple traits selection. Based on multiple traits selection we found 50 the best F2 segregation.

Keywords: differential selection, early generation, heat tolerant, heritability, gene action, variability genetics coeffiecient
Pengembangan Kriteria Seleksi untuk Perakitan Terung (Solanum melongena L.) Berdaya Hasil Tinggi
Authors: Putri Faradila Danasworo , , Sobir , Syukur Muhamad , Maharijaya Dan Awang
Published: December 2017

Eggplants (Solanum melongena L.) are consumed worldwide in a variety of colors, shapes and sizes, thus vegetable plant breeders place great interest in developing high yielding genotypes in response to the population growth and the need to increase vegetable production. This research was aimed to determine the proper character as selection character for breeding high yielding eggplants by using estimated heritability value, coefficient of genetic diversity, characters correlation and path analysis. The experiment was conducted during 2014 to August 2015 at Cikabayan Experimental Field, Tajur Experimental Field and Pasir Sarongge Experimental Field, IPB, West Java. A total of 12 characters was observed in the 25 genotypes. Eleven characters has a high estimated heritability value and high coefficient of genetic diversity value. Those characters were time of flowering, time of harvest, fruit length, fruit weight, fruit diameter, plant height, stem length, fruit apical scar length, calyx length, the number of fruits per plant and fruit weight per plant. Results of correlation and path analysis showed that fruit length, fruit weight, fruit diameter, stem diameter, calyx length and number of fruits per plant have a direct positive effect on fruit weight per plant. Fruit weight, fruit diameter and number of fruits per plant are suitable characters in determining the selection criteria for developing high productivity eggplant.

Keywords: path analysis, correlation, heritability, genetic diversity coefficient