bluuebunny/crossref_metadata_2025 huggingface dataset:
Adjuvant Radiotherapy Is Associated with an Increase in the Survival of Old (Aged over 80 Years) and Very Old (Aged over 90 Years) Women with Breast Cancer Receiving Breast-Conserving Surgery
Authors: Huang Chung-Chien , Chang Chia-Lun , Sun Mingyang , Chiang Ming-Feng , Sum Shao-Yin , Zhang Jiaqiang , Wu Szu-Yuan
Published: February 2022

This study is the first to examine the effect of adjuvant whole-breast radiotherapy (WBRT) on oncologic outcomes such as all-cause death, locoregional recurrence (LRR), and distant metastasis (DM) in old (aged ≥80 years) and very old (aged ≥90 years) women with breast invasive ductal carcinoma (IDC) receiving breast-conserving surgery. After propensity score matching, adjuvant WBRT was associated with decreases in all-cause death, LRR, and DM in old and very old women with IDC compared with no use of adjuvant WBRT. Background: To date, no data on the effect of adjuvant whole-breast radiotherapy (WBRT) on oncologic outcomes, such as all-cause death, locoregional recurrence (LRR), and distant metastasis (DM), are available for old (aged ≥80 years) and very old (≥90 years) women with breast invasive ductal carcinoma (IDC) receiving breast-conserving conservative surgery (BCS). Patients and Methods: We enrolled old (≥80 years old) and very old (≥90 years old) women with breast IDC who had received BCS followed by adjuvant WBRT or no adjuvant WBRT. We grouped them based on adjuvant WBRT status and compared their overall survival (OS), LRR, and DM outcomes. To reduce the effects of potential confounders when comparing all-cause mortality between the groups, propensity score matching was performed. Results: Overall, 752 older women with IDC received BCS followed by adjuvant WBRT, and 752 with IDC received BCS with no adjuvant WBRT. In multivariable Cox regression analysis, the adjusted hazard ratio (aHR) and 95% confidence interval (95% CI) of all-cause death for adjuvant WBRT compared with no adjuvant WBRT in older women with IDC receiving BCS was 0.56 (0.44–0.70). The aHRs (95% CIs) of LRR and DM for adjuvant WBRT were 0.29 (0.19–0.45) and 0.45 (0.32–0.62), respectively, compared with no adjuvant WBRT. Conclusions: Adjuvant WBRT was associated with decreases in all-cause death, LRR, and DM in old (aged ≥80 years) and very old (aged ≥90 years) women with IDC compared with no adjuvant WBRT.
Conterminous United States Land-Cover Change (1985–2016): New Insights from Annual Time Series
Authors: Auch Roger F. , Wellington Danika F. , Taylor Janis L. , Stehman Stephen V. , Tollerud Heather J. , Brown Jesslyn F. , Loveland Thomas R. , Pengra Bruce W. , Horton Josephine A. , Zhu Zhe , Midekisa Alemayehu A. , Sayler Kristi L. , Xian George , Barber Christopher P. , Reker Ryan R.
Published: February 2022

Sample-based estimates augmented by complete coverage land-cover maps were used to estimate area and describe patterns of annual land-cover change across the conterminous United States (CONUS) between 1985 and 2016. Most of the CONUS land cover remained stable in terms of net class change over this time, but a substantial gross change dynamic was captured by the annual and cumulative time intervals. The dominant types of changes can be grouped into natural resource cycles, increases in urbanization, and surface-water dynamics. The annual estimates over the 30-year time series showed a reduction in the rate of urban expansion after 2006, new growth in cropland after 2007, but a net overall decline in cropland since 1985, and two eras of net tree cover loss, the first one early in the time series and the second starting in 2012. Our study provides a holistic assessment of the CONUS land-cover conversion (class) change and can serve as a new benchmark for future research.
A Simple and Efficient Approach to the Synthesis of 4-Aryl-2-dialkylphosphonomethyl-4-oxobutanenitrile
Authors: Yaccoubi Ferid , Elleuch Hitham , Mohamed Hussein S. , Hamza Zeinab S. , Zaki Yasser H.
Published: February 2022

In this work, we describe a simple and easy synthetic approach to variously 4-aryl-2-alkylphosphonomethyl-4-oxobutanenitrile based on the reaction of aromatic aldehydes with phosphorylated Michael’s acceptors in good yields. A general mechanism for the reactions was also proposed. Characterization of the products was carried out by several spectroscopic tools, including Infrared and Nuclear Magnetic Resonance Spectroscopies (1H, 13C, and 31P-NMR). Molecular docking studies were conducted on the synthesized materials against (1UK4) the crystal structure of the SARS Coronavirus Main Proteinase (3CLpro) to study the antiviral activity of these compounds and against (1E3K) the Human Progesterone Receptor to study the anticancer activity of these compounds. We found that compound (5i) was the best one in both antiviral and anticancer activity (according to the binding energy values).
Facile Synthesis of Unsupported Pd Aerogel for High Performance Formic Acid Microfluidic Fuel Cell
Authors: Martínez-Lázaro Alejandra , Ramírez-Montoya Luis A. , Ledesma-García Janet , Montes-Morán Miguel A. , Gurrola Mayra P. , Menéndez J. Angel , Arenillas Ana , Arriaga Luis G.
Published: February 2022

In this work, unsupported Pd aerogel catalysts were synthesized for the very first time by using microwaves as a heating source followed by a lyophilization drying process and used towards formic acid electro-oxidation in a microfluidic fuel cell. Aerogels were also made by heating in a conventional oven to evaluate the microwave effect during the synthesis process of the unsupported Pd aerogels. The performance of the catalysts obtained by means of microwave heating favored the formic acid electro-oxidation with H2SO4 as the electrolyte. The aerogels’ performance as anodic catalysts was carried out in a microfluidic fuel cell, giving power densities of up to 14 mW cm−2 when using mass loads of only 0.1 mg on a 0.019 cm2 electrode surface. The power densities of the aerogels obtained by microwave heating gave a performance superior to the resultant aerogel prepared using conventional heating and even better than a commercial Pd/C catalyst.
Effect of Dynamic Recrystallization on Microstructural Evolution in B Steels Microalloyed with Nb and/or Mo
Authors: Zurutuza Irati , Isasti Nerea , Detemple Eric , Schwinn Volker , Mohrbacher Hardy , Uranga Pello
Published: February 2022

The dynamic recrystallization behavior of ultra-high strength boron-microalloyed steels optionally alloyed with niobium and molybdenum is analyzed in this paper. Multipass torsion tests were performed to simulate plate rolling conditions followed by direct quenching. The influence of alloy composition on the transformed microstructure was evaluated by means of EBSD, thereby characterizing the morphology of the austenite grain morphology after roughing and finishing passes. The results indicated that for Nb-microalloyed steel, partial dynamic recrystallization occurred and resulted in local clusters of fine-sized equiaxed grains dispersed within the pancaked austenitic structure. A recrystallized austenite fraction appeared and transformed into softer phase constituents after direct quenching. The addition of Mo was shown to be an effective means of suppressing dynamic recrystallization. This effect of molybdenum in addition to its established hardenability effects hence safeguards the formation of fully martensitic microstructures, particularly in direct quenching processes. Additionally, the circumstances initiating dynamic recrystallization were studied in more detail, and the interference of the various alloying elements with the observed phenomena and the potential consequences of dynamic recrystallization before quenching are discussed.
An Approximate Method for Calculating Elastic–Plastic Stress and Strain on Notched Specimens
Authors: Lutovinov Maxim , Halama Radim , Papuga Jan , Bartošák Michal , Kuželka Jiří , Růžička Milan
Published: February 2022

The paper deals with an approximate method for calculating elastic–plastic stresses and strains on the surface of notched samples. The method is based on the Abdel–Karim–Ohno cyclic plasticity model. The plane stress condition is considered within the evaluation. The output of the approximation on several multiaxial axial–torsion load paths is compared to our own experimental results. Experiments were carried out on samples of two notch types manufactured from the 2124-T851 aluminum alloy. Strain distribution in the notch area was measured by digital image correlation. The comparison between computational solution and measured response shows that the new method allows for obtaining reasonably good approximation, even for relatively complicated multiaxial load cases.
Thermal Mass Effect on the Solution Cooling Rate and on HIPped Astroloy Component Properties
Authors: Napal Unai Galech , Segarra Miren Aristizabal , Lazcano Borja Elguezabal , Sivo Antonio , Zubillaga Iñigo Iturriza
Published: February 2022

Astroloy is a Ni-based superalloy with high-volume fraction of γ′, which gives high temperature properties but reduces its forgeability. Therefore, powder metallurgy manufacturing processes such as Near Net Shape HIPping are the most suitable manufacturing technology for Astroloy. However, NNSHIP has its own drawbacks, such as the formation of prior particle boundaries (PPBs), which usually tend to decrease material mechanical properties. The detrimental effect of PPBs can be reduced by optimizing the entire HIP processing route. Conventional HIP cycles have very low cooling rates, especially in big components from industry, and thus a series of post-heat treatments must be applied in order to achieve desirable microstructures and improve the mechanical properties. Standard heat treatments for Astroloy are long and tedious with several steps of solutioning, stabilization and precipitation. In this work, two main studies have been performed. First, the effect of the cooling rate after the solutioning treatment, which is driven by the materials’ thermal mass, on the Astroloy microstructure and mechanical properties was studied. Experimental analyses and simulation techniques have been used in the present work and it has been found that higher cooling rates after solutioning increase the density of tertiary γ′ precipitates by 85%, and their size decreases by 22%, which leads to an increase in hardness from 356 to 372 HB30. This hardness difference tends to reduce after subsequent standard heat treatment (HT) that homogenizes the microstructure. The second study shows the effect of different heat treatments on the microstructure and hardness of samples with two different thermal masses (can and cube). More than double the density of γ′ precipitates was found in small cubes in comparison with cans with a higher thermal mass. Therefore, the hardness in cubes is between 4 and 20 HB 30 higher than in large cans, depending on the applied HT.
The Performance of Concrete Made with Secondary Products—Recycled Coarse Aggregates, Recycled Cement Mortar, and Fly Ash–Slag Mix
Authors: Kalinowska-Wichrowska Katarzyna , Pawluczuk Edyta , Bołtryk Michał , Jimenez Jose Ramón , Fernandez-Rodriguez Jose Maria , Suescum Morales David
Published: February 2022

The properties of cement concrete using waste materials—namely, recycled cement mortar, fly ash–slag, and recycled concrete aggregate—are presented. A treatment process for waste materials is proposed. Two research experiments were conducted. In the first, concretes were made with fly ash–slag mix (FAS) and recycled cement mortar (RCM) as additions. The most favorable content of the concrete additive in the form of RCM and FAS was determined experimentally, and their influence on the physical and mechanical properties of concrete was established. For this purpose, 10 test series were carried out according to the experimental plan. In the second study, concretes containing FAS–RCM and recycled concrete aggregate (RCA) as a 30% replacement of natural aggregate (NA) were prepared. The compressive strength, frost resistance, water absorption, volume density, thermal conductivity, and microstructure were researched. The test results show that the addition of FAS–RCM and RCA can produce composites with better physical and mechanical properties compared with concrete made only of natural raw materials and cement. The detailed results show that FAS–RCM can be a valuable substitute for cement and RCA as a replacement for natural aggregates. Compared with traditional cement concretes, concretes made of FAS, RCM, and RCA are characterized by a higher compressive strength: 7% higher in the case of 30% replacement of NA by RCA with the additional use of the innovative FAS–RCM additive as 30% of the cement mass.
Microstructure Evolution of 7075 Aluminum Alloy by Rotary
Authors: Cao Hui , Yang Yongbiao , Zhang Xing , Ma Jin , Zhang Tingyan , Zhang Zhimin
Published: February 2022

This study proposed a rotary back extrusion (RBE) process for an open punch, which is used to produce high-performance 7075 aluminum alloy cup-shaped piece. The RBE experiment was carried out on the Gleeble-3500 testing machine at 400 °C and compared with the conventional back extrusion (CBE). The microstructure was analyzed by optical microscope, scanning electron microscope and DEFORM-3D simulation software. The results shown that compared with CBE, RBE can significantly increase the equivalent strain value and deformation uniformity of 7075 aluminum alloy cup-shape pieces. RBE deformation increases the accumulated strain of the piece, and the rotation of the die causes the piece to produce shear strain, which increases the overall strain of the cup-shape piece. The proportion of dynamic recrystallization increases, and the grain refinement was obvious. The micro-hardness value of the RBE sample is higher than that of the CBE sample, which could be the result of grain refinement strengthening. What is more, RBE and CBE have different metal flow laws.
The Effect of Alcohol Compound on the Solidification of Magnesium Oxysulfate Cement-Boron Mud Blends
Authors: Liang Yuanyuan , Guan Yan , Bi Wanli
Published: February 2022

At present, the utilization of boron resources in China is increasing, and the problem of boron tailing pollution is becoming increasingly serious. To fundamentally solve the problem of boron tailing, many scholars at home and abroad have mainly studied the curing effect in terms of compressive strength, and little research has been carried out into the solidification effect and hydration products. This study explored the effects of adding different alcohol-based modifiers on the hydration products of magnesium oxysulfate cement-boron mud mixture, the microstructure, physical properties and curing effects of the samples. The results show that magnesium oxysulfate cement is beneficial to the solidification of boron in boron mud due to its low-alkali. Adding an alcohol-based modifier can increase the compressive strength of magnesium oxysulfate cement-boron mud blends. After adding acrylic acid and D-Mannitol, the 28-day compressive strength of the sample increased by 44.7 MPa. The blending of alcohol-based modifiers has a very good effect on the curing of boron in the whole system.
Low Cost Embedded Copper Mesh Based on Cracked Template for Highly Durability Transparent EMI Shielding Films
Authors: Voronin Anton S. , Fadeev Yurii V. , Makeev Mstislav O. , Mikhalev Pavel A. , Osipkov Alexey S. , Provatorov Alexander S. , Ryzhenko Dmitriy S. , Yurkov Gleb Y. , Simunin Mikhail M. , Karpova Darina V. , Lukyanenko Anna V. , Kokh Dieter , Bainov Dashi D. , Tambasov Igor A. , Nedelin Sergey V. , Zolotovsky Nikita A. , Khartov Stanislav V.
Published: February 2022

Embedded copper mesh coatings with low sheet resistance and high transparency were formed using a low-cost Cu seed mesh obtained with a magnetron sputtering on a cracked template, and subsequent operations electroplating and embedding in a photocurable resin layer. The influence of the mesh size on the optoelectric characteristics and the electromagnetic shielding efficiency in a wide frequency range is considered. In optimizing the coating properties, a shielding efficiency of 49.38 dB at a frequency of 1 GHz, with integral optical transparency in the visible range of 84.3%, was obtained. Embedded Cu meshes have been shown to be highly bending stable and have excellent adhesion strength. The combination of properties and economic costs for the formation of coatings indicates their high prospects for practical use in shielding transparent objects, such as windows and computer monitors.
Prognostic Impact of Active Cigarette Smoking on Mortality in Patients with Acute Venous Thromboembolic Events, Findings from Real World Data
Authors: Giorgi-Pierfranceschi Matteo , Monreal Manuel , Di Micco Pierpaolo , Francisco Iria , Hernández-Blasco Luis , Madridano Olga , López-Sáez Juan Bosco , Hernando Elena , Meireles Jose , Dentali Francesco ,   the RIETE Investigators
Published: February 2022

Background and Objectives: The influence of smoking habits on mortality, VTE recurrence, and major bleeding in patients receiving anticoagulant therapy for venous thromboembolism (VTE) has not been consistently evaluated. Materials and Methods: We used data from the RIETE (Registro Enfermedad TromboEmbólica) registry to compare mortality, VTE recurrence, and major bleeding risk in smoking versus non-smoking patients with acute VTE. Results: 50,881 patients (43,426 non-smoking and 7455 smoking patients) were included. After a median follow-up of 8.8 months, 7110 patients died (fatal PE 292 and fatal bleeding 281), 3243 presented VTE recurrence, and 1579 had major bleeding. At multivariate analysis, smoking behavior was associated with a higher hazard of death, (HR: 1.28; 95% CI: 1.19–1.40). The risk of VTE recurrence was marginally increased in smoking patients compared to non-smoking patients (1.14; 95% CI: 1.02–1.27). Major bleeding did not differ in smoking and non-smoking patients (1.15; 95% CI: 0.96–1.38). The presence of cancer did not appear to influence the association between smoking habits and death (HR: 1.34; 95% CI: 1.22–1.47 in cancer patients and HR: 1.23; 95% CI: 1.04, 1.45 in non-cancer patients, respectively) Conclusions: the risk of death after an acute episode of VTE appeared to be higher in smoking than in non-smoking patients and this risk is higher between patients presenting PE at the onset of symptoms.
Interactive Inhibition of Aflatoxigenic Aspergillus flavus and Ochratoxigenic Aspergillus carbonarius by Aspergillus oryzae under Fluctuating Temperatures
Authors: Dwipa Retty Putri Utami , Maneeboon Thanapoom , Chuaysrinule Chananya , Mahakarnchanakul Warapa
Published: February 2022

This study aimed to evaluate the effectiveness of A. oryzae in inhibiting aflatoxin B1 (AFB1) and ochratoxin A (OTA) production by A. flavus and A. carbonarius, respectively, under shifting temperatures. A. oryzae was tested on different agar, namely coconut cream agar (CCA) and chili-based agar to figure out the variation in the effectiveness of A. oryzae on the most appropriate medium for A. flavus and A. carbonarius to produce mycotoxin and under natural condition where they are predominantly found. On CCA, the temperatures applied were 20, 30, 35, 40, 20/30, 20/35, and 20/40 °C, while on chili-based agar, the temperatures imposed were 20, 40, and 20/40 °C, at varied water activity of 0.92 and 0.97aw. The findings indicated that A. oryzae was much more effective in inhibiting the growth of A. flavus rather than A. carbonarius, yet it was able to inhibit higher OTA concentration than AFB1 at fluctuating temperatures on CCA as the most appropriate medium for A. flavus and A. carbonarius. A. oryzae effectively inhibited AFB1 and OTA at static temperature of 20 °C and water activity of 0.97aw on chili-based agar. Under fluctuating temperatures (20/40 °C), A. oryzae was also able to control mycotoxin, particularly OTA at high water activity (0.97aw).
The Leaf Microbiome of Tobacco Plants across Eight Chinese Provinces
Authors: Hu Haiyang , Liu Yunli , Huang Yiqun , Zhang Zhan , Tang Hongzhi
Published: February 2022

Leaf microorganism communities play significant roles in the process of plant growth, but the microbiome profiling of crop leaves is still a relatively new research area. Here, we used 16S rDNA sequencing to profile the microbiomes of 78 primary dried tobacco leaf samples from 26 locations in eight Chinese provinces. Our analyses revealed that the national leaf microbial communities contain 4473 operational taxonomic units (OTU) representing 1234 species, but there is a small, national core microbiome with only 14 OTU representing nine species. The function of this core microbiome is related to processes including nitrogen fixation, detoxification of diverse pollutants, and heavy-metal reduction. The leaf microorganism communities are obviously affected by local environments but did not exhibit obvious relationships to single ecological factors (e.g., temperature, precipitation). Our findings enhance the understanding of microbial diversity of tobacco leaves, which could be utilized for a variety of bioprocess, agricultural, and environmental detoxification applications.
Research on the Selective Grinding of Zn and Sn in Cassiterite Polymetallic Sulfide Ore
Authors: Yang Jinlin , Xu Wenzhe , Deng Xingjian , Li Hengjun , Ma Shaojian
Published: February 2022

When cassiterite polymetallic sulfide ore is being ground in the ball mill, the contradiction between over grinding of cassiterite and under grinding of sulfide ore is inevitable due to their mechanical property differences. In this paper, a selective grinding characterization method is proposed to optimize the grinding of cassiterite polymetallic sulfide ore based on the respective selective grinding indexes, namely, the changes in the cumulative grade and cumulative quantities of metal. The preferred grinding characteristics were studied by varying three grinding operation factors, the grinding time, grinding concentration, and mill speed, as these all affect the selective grinding behavior of the ball mill. In the proposed method, the breaking process preferentially begins with the Zn minerals in the cassiterite polymetallic sulfide ore; however, Sn minerals are found to break first when the specific energy of the grinding media is large. The differences in the crushing characteristics of Zn and Sn minerals narrow down as the grinding time and concentration increase. When the grinding concentration is lower than 50%, the two types of minerals are broken with little difference. However, when the grinding concentration is higher than 50%, the Zn minerals are broken prior to the Sn minerals.
Photolytic Measurement of Tissue S-Nitrosothiols in Rats and Humans In Vivo
Authors: Neidigh Noah , Alexander Alyssa , van Emmerik Parker , Higgs Allison , Plack Logan , Clem Charles , Cater Daniel , Marozkina Nadzeya , Gaston Benjamin
Published: February 2022

S-nitrosothiols are labile thiol-NO adducts formed in vivo primarily by metalloproteins such as NO synthase, ceruloplasmin, and hemoglobin. Abnormal S-nitrosothiol synthesis and catabolism contribute to many diseases, ranging from asthma to septic shock. Current methods for quantifying S-nitrosothiols in vivo are suboptimal. Samples need to be removed from the body for analysis, and the S-nitrosothiols can be broken down during ex vivo processing. Here, we have developed a noninvasive device to measure mammalian tissue S-nitrosothiols in situ non-invasively using ultraviolet (UV) light, which causes NO release in proportion to the S-nitrosothiol concentration. We validated the assay in vitro; then, we applied it to measure S-nitrosothiols in vivo in rats and in humans. The method was sensitive to 0.5 µM, specific (did not detect other nitrogen oxides), and was reproducible in rats and in humans. This noninvasive approach to S-nitrosothiol measurements may be applicable for use in human diseases.
Phytochemicals Mediated Synthesis of AuNPs from Citrullus colocynthis and Their Characterization
Authors: Mubeen Bismillah , Rasool Mahvish Ghulam , Ullah Inam , Rasool Rabia , Imam Syed Sarim , Alshehri Sultan , Ghoneim Mohammed M. , Alzarea Sami I. , Nadeem Muhammad Shahid , Kazmi Imran
Published: February 2022

Engineered nanoparticles that have distinctive targeted characteristics with high potency are modernistic technological innovations. In the modern era of research, nanotechnology has assumed critical importance due to its vast applications in all fields of science. Biologically synthesized nanoparticles using plants are an alternative to conventional methods. In the present study, Citrullus colocynthis (bitter apple) was used for the synthesis of gold nanoparticles (AuNPs). UV-Vis’s spectroscopy, XRD, SEM and FTIR were performed to confirm the formation of AuNPs. UV-Vis’s spectra showed a characteristic peak at the range of 531.5–541.5 nm. XRD peaks at 2 θ = 38°, 44°, 64° and 77°, corresponding to 111, 200, 220 and 311 planes, confirmed the crystalline nature of AuNPs. Spherical AuNPs ranged mostly between 7 and 33 nm, and were measured using SEM. The FTIR analysis confirmed the presence of phytochemicals on the surface of AuNPs. Successful synthesis of AuNPs by seed extract of Citrullus colocynthis (bitter apple) as a capping and reducing agent represents the novelty of the present study.
Diels–Alder Cycloaddition Reactions in Sustainable Media
Authors: Soares Maria I. L. , Cardoso Ana L. , Pinho e Melo Teresa M. V. D.
Published: February 2022

Diels–Alder cycloaddition reaction is one of the most powerful strategies for the construction of six-membered carbocyclic and heterocyclic systems, in most cases with high regio- and stereoselectivity. In this review, an insight into the most relevant advances on sustainable Diels–Alder reactions since 2010 is provided. Various environmentally benign solvent systems are discussed, namely bio-based derived solvents (such as glycerol and gluconic acid), polyethylene glycol, deep eutectic solvents, supercritical carbon dioxide, water and water-based aqueous systems. Issues such as method’s scope, efficiency, selectivity and reaction mechanism, as well as sustainability, advantages and limitations of these reaction media, are addressed.
Synthesis, Characterization, and Catalytic Exploration of Mononuclear Mo(VI) Dioxido Complexes of (Z)-1-R-2-(4′,4′-Dimethyl-2′-oxazolin-2′-yl)-eth-1-en-1-ates
Authors: Petrov Anna , Adjei Jeanette A. , Lough Alan J. , Wylie R. Stephen , Gossage Robert A.
Published: February 2022

The coordination chemistry of the title ligands with Mo metal centers was investigated. Thus, the synthesis and characterization (NMR, X-ray diffraction) of four mononuclear formally Mo(6+) complexes of (Z)-1-R-2-(4′,4′-dimethyl-2′-oxazolin-2′-yl)-eth-1-en-1-ates (L: R = –Ph, –Ph-p-NO2, –Ph-p-OMe and –t-Bu), derived from the part enols (LH), is described. The resulting air-stable MoO2L2 complexes (1–4) exist, as shown by single-crystal X-ray diffraction experiments, in the cis-dioxido-trans(N)-κ2-N,O-L conformation in the solid state for all four examples. This situation was further probed using semi-empirical PM6(tm) calculations. Complexes 1–4 represent the first Mo complexes of this ligand class and, indeed, of Group 6 metals in general. Structural and spectroscopic comparisons were made between these and related Mo(6+) compounds. Complex 1 (R = –Ph) was studied for its ability to selectively catalyze the production of poly-norbornene from the monomer in the presence of MAO. This, unfortunately, only resulted in the synthesis of insoluble, presumably highly cross-linked, polymeric and/or oligomeric materials. However, complexes 1–4 were demonstrated to be highly effective for catalyzing benzoin to benzil conversion using DMSO as the O-transfer agent. This catalysis work is likewise put into perspective with respect to analogous Mo(6+) complexes.
Volatile Analysis of Wuliangye Baijiu by LiChrolut EN SPE Fractionation Coupled with Comprehensive GC×GC-TOFMS
Authors: Zheng Jia , He Zhanglan , Yang Kangzhuo , Liu Zhipeng , Zhao Dong , Qian Michael C.
Published: February 2022

Wuliangye baijiu is one of the most famous Chinese liquors with a protected geographical indication. This study used LiChrolut® EN-based solid-phase extraction (SPE) and fractionation combined with comprehensive two-dimensional chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS) to unveil its volatile composition. The volatiles were isolated with LiChrolut® EN-based SPE and traditional liquid-liquid extraction (LLE). The neutral/basic fractions from LLE and the SPE were fractionated on a LiChrolut® EN SPE column and analyzed by comprehensive GC×GC-TOFMS. Compared with LLE, more esters and alcohols were detected in the SPE-based extraction. The SPE fractionation and GC×GC-TOFMS analysis resulted in the identification of about 500 volatile compounds in more than 3000 peaks of the Wuliangye baijiu. The approach simplifies the complex baijiu composition into functional group-based fractions for reliable identification and analysis. This study provided a confidence volatile identification approach for Chinese baijiu based on the SPE fractionation GC×GC-TOFMS.
Laser-Ablative Synthesis of Ultrapure Magneto-Plasmonic Core-Satellite Nanocomposites for Biomedical Applications
Authors: Popov Anton A. , Swiatkowska-Warkocka Zaneta , Marszalek Marta , Tselikov Gleb , Zelepukin Ivan V. , Al-Kattan Ahmed , Deyev Sergey M. , Klimentov Sergey M. , Itina Tatiana E. , Kabashin Andrei V.
Published: February 2022

The combination of magnetic and plasmonic properties at the nanoscale promises the development of novel synergetic image-guided therapy strategies for the treatment of cancer and other diseases, but the fabrication of non-contaminated magneto-plasmonic nanocomposites suitable for biological applications is difficult within traditional chemical methods. Here, we describe a methodology based on laser ablation from Fe target in the presence of preliminarily ablated water-dispersed Au nanoparticles (NPs) to synthesize ultrapure bare (ligand-free) core-satellite nanostructures, consisting of large (several tens of nm) Fe-based core decorated by small (mean size 7.5 nm) Au NPs. The presence of the Fe-based core conditions a relatively strong magnetic response of the nanostructures (magnetization of >12.6 emu/g), while the Au NPs-based satellite shell provides a broad extinction peak centered at 550 nm with a long tale in the near-infrared to overlap with the region of relative tissue transparency (650–950 nm). We also discuss possible mechanisms responsible for the formation of the magnetic-plasmonic nanocomposites. We finally demonstrate a protocol to enhance colloidal stability of the core-satellites in biological environment by their coating with different polymers. Exempt of toxic impurities and combining strong magnetic and plasmonic responses, the formed core-satellite nanocomposites can be used in biomedical applications, including photo- and magneto-induced therapies, magnetic resonance imaging or photoacoustic imaging.
The Impact of Dietary Diversity, Lifestyle, and Blood Lipids on Carotid Atherosclerosis: A Cross-Sectional Study
Authors: Wang Yaqin , Li Lijun , Li Ying , Liu Min , Gan Gang , Zhou Yi , Luo Xiaofei , Zhang Chun , Xie Jianfei , Duan Yinglong , Cheng (Andy) S. K.
Published: February 2022

Carotid atherosclerosis is a common arterial wall lesion that causes narrowing and occlusion of the arteries and is the basis of cardiovascular events. Dietary habits, lifestyle, and lipid metabolism should be considered integrally in the context of carotid atherosclerosis (CAS). However, this area has been investigated less often in China. To understand the prevalence of CAS in China and the impact of dietary diversity and habits, lifestyle, and lipid metabolism on CAS as well as its predictive factors, a cross-sectional study was performed in two northern and southern Chinese tertiary hospitals from 2017 to 2019. Included participants underwent carotid artery color Doppler ultrasonography, blood lipid examination and dietary evaluation. In total, 11,601 CAS patients and 27,041 individuals without carotid artery lesions were included. The prevalence of CAS was 30.0% in this group. High BMI (OR: 1.685, 95% CI [1.315–2.160]), current (1.148 [1.077–1.224]) or ex-smoking (1.349 [1.190–1.529]), abstinence from alcohol ((1.223 [1.026–1.459]), social engagement (1.122 [1.050–1.198]), hypertension (1.828 [1.718–1.945]), and total cholesterol (1.438 [1.298–1.594]) were risk factors for CAS, while higher dietary diversity according to DDS-2 (0.891 [0.805–0.989]), HDL-C (0.558 [0.487–0.639]), sugar-sweetened beverages (0.734 [0.696–0.774]), and no midnight snack consumption (0.846 [0.792–0.903]) were protective factors. This current study demonstrated that higher dietary diversity was a protective factor against CAS in a healthy population. In addition, current recommendations of healthy lifestyle and dietary habits for preventing CAS should be strengthened. In addition, dietary diversity should concentrate on food attributes and dietary balance, rather than increased quantities.
Enhanced Anticancer Activity of Nedaplatin Loaded onto Copper Nanoparticles Synthesized Using Red Algae
Authors: Aboeita Nada Mostafa , Fahmy Sherif Ashraf , El-Sayed Mayyada M. H. , Azzazy Hassan Mohamed El-Said , Shoeib Tamer
Published: February 2022

Marine algae are a rich source of biologically active compounds that can be utilized in various food and pharmaceutical applications. In this study, ultrasound-assisted extraction (UAE) was optimized to maximize yield and total carbohydrate content extracted from the red algae, Pterocladia capillacea. The extract was shown to possess potent antioxidant activity of up to ~70%, and was successfully used as a reducing and capping agent in the green synthesis of copper nanoparticles, which were characterized by UV-spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS). Primarily, CuO nanoparticles with an average size of 62 nm were produced. FTIR spectra for the extract and algal-mediated CuO nanoparticles showed characteristic polysaccharide peaks. The synthesized CuO nanoparticles were subsequently loaded with nedaplatin where UV data suggested a complex formation. Nedaplatin release profiles showed a sustained release that reached a maximum at 120 h. The formulation was shown to have greater cytotoxicity relative to nedaplatin on hepatocellular carcinoma, breast cancer and ovarian cancer cell lines with IC50 values of 0.40 ± 0.08, 1.50 ± 0.12, and 0.70 ± 0.09 µg/mL, respectively. Loading nedaplatin onto CuO nanoparticles synthesized using red algae extract, greatly enhances its anticancer effect.
Research on the Regulatory Mechanism of Algae Reproduction under Abiotic Stress Conditions
Authors: Mikami Koji
Published: February 2022

The intertidal and subtidal zones are characterized by daily and seasonal fluctuations in environmental conditions [...]
Developmental Stages Affect the Capacity to Produce Aldehyde Green Leaf Volatiles in Zea mays and Vigna radiata
Authors: Engelberth Jurgen , Engelberth Marie
Published: February 2022

Green leaf volatiles (GLV) are essentially produced by the green parts of plants upon damage. GLV are mainly 6-carbon molecules derived from fatty acids through the hydroperoxide lyase pathway and can serve as airborne signals to other parts of the same plant and to neighboring plants and help to protect them against biotic and abiotic stresses. However, while the biosynthesis is generally well understood, little is known about how plants regulate the production of these important signaling molecules. To better understand how the developmental stage of the plant affects aldehyde GLV production, we selected Zea mays and Vigna radiata to represent mono- and dicot plants for this analysis. We show that the capacity to produce aldehyde GLV strongly depends on the developmental stage of the plant. Major differences in the quantity, and in the quality of these compounds were found, not only in leaves from different developmental stages, but also in different areas within a leaf. The results demonstrate that the capacity to produce GLV varies significantly within a plant and the potential implications of these findings are discussed.
Enriching WPCs and NFPCs with Carbon Nanotubes and Graphene
Authors: Łukawski Damian , Hochmańska-Kaniewska Patrycja , Janiszewska Dominika , Wróblewski Grzegorz , Patmore Jeff , Lekawa-Raus Agnieszka
Published: February 2022

Carbon nanotubes (CNTs) and graphene, with their unique mechanical, electrical, thermal, optical, and wettability properties, are very effective fillers for many types of composites. Recently, a number of studies have shown that CNTs and graphene may be integrated into wood–plastic composites (WPCs) and natural-fibre-reinforced polymer composites (NFPCs) to improve the existing performance of the WPCs/NFPCs as well as enabling their use in completely new areas of engineering. The following review analyses the results of the studies presented to date, from which it can be seen that that inclusion of CNTs/graphene may indeed improve the mechanical properties of the WPCs/NFPCs, while increasing their thermal conductivity, making them electroconductive, more photostable, less sensitive to water absorption, less flammable, and more thermally stable. This study indicates that the composition and methods of manufacturing of hybrid WPCs/NFPCs vary significantly between the samples, with a consequent impact on the level of improvement of specific properties. This review also shows that the incorporation of CNTs/graphene may enable new applications of WPCs/NFPCs, such as solar thermal energy storage devices, electromagnetic shielding, antistatic packaging, sensors, and heaters. Finally, this paper recognises key challenges in the study area, and proposes future work.
Stochastic Resonance in Organic Electronic Devices
Authors: Suzuki Yoshiharu , Asakawa Naoki
Published: February 2022

Stochastic Resonance (SR) is a phenomenon in which noise improves the performance of a system. With the addition of noise, a weak input signal to a nonlinear system, which may exceed its threshold, is transformed into an output signal. In the other words, noise-driven signal transfer is achieved. SR has been observed in nonlinear response systems, such as biological and artificial systems, and this review will focus mainly on examples of previous studies of mathematical models and experimental realization of SR using poly(hexylthiophene)-based organic field-effect transistors (OFETs). This phenomenon may contribute to signal processing with low energy consumption. However, the generation of SR requires a noise source. Therefore, the focus is on OFETs using materials such as organic materials with unstable electrical properties and critical elements due to unidirectional signal transmission, such as neural synapses. It has been reported that SR can be observed in OFETs by application of external noise. However, SR does not occur under conditions where the input signal exceeds the OFET threshold without external noise. Here, we present an example of a study that analyzes the behavior of SR in OFET systems and explain how SR can be made observable. At the same time, the role of internal noise in OFETs will be explained.
Development and Characterization of Plantain (Musa paradisiaca) Flour-Based Biopolymer Films Reinforced with Plantain Fibers
Authors: Venegas Ramiro , Torres Andres , Rueda Ana M. , Morales Maria A. , Arias Mary J. , Porras Alicia
Published: February 2022

Agroindustrial wastes are a cheap and abundant source of natural fibers and macromolecules that can be used in the manufacturing of biocomposites. This study presents the development and thermo-mechanical characterization of a bio-composite film (TPF/PF), made of thermoplastic banana flour (TPF) matrix and plantain fibers (PF). Fabricated materials were characterized by physical analysis, chemical composition, Fourier-transformed spectroscopy (FTIR), thermal analysis (TGA), mechanical analysis, and scanning electronic microscopy (SEM). The physical analysis showed that TPF and PF have a low density and high affinity to water resulting in a lightweight, renewable, and biodegradable TPF/PF composite. The chemical composition and spectra analysis of the fiber showed that PF is a potential candidate for reinforcing composites due to its high α-cellulose and low lignin content. The thermal analysis determined that TPF degrades at a lower temperature than PF, therefore the matrix sets the processing temperature for TPF/PF composite films. The mechanical test showed an improvement in the tensile properties of the composite in comparison to neat TPF. Tensile strength and Young’s modulus were improved by 345% and 1196%, respectively, when PF fibers was used. Good bonding and mechanical interlocking of PF to the TPF were identified by SEM. Therefore, potential biocomposites can be developed using natural fibers and thermoplastic starches obtained from plantain agroindustrial wastes.
Circular Economy Assessment in Recycling of LLDPE Bags According to European Resolution, Thermal and Structural Characterization
Authors: Ballestar Ricardo , Pradas Celia , Carrillo-Navarrete Fernando , Cañavate Javier , Colom Xavier
Published: February 2022

According to the Circular Economy Package promoted by the European directive, plastic bags companies must use in their formulations a percentage of polyethylene waste (industrial and/or domestic) greater than 70%. Following that regulation requires an understanding of its consequences in the final product from an industrial point of view. This manuscript analyzes the thermal and morphological changes related to the tear resistance of linear-low density polyethylene (LLDPE) samples from industrial waste generated by the company Sphere Spain subjected to the degradation produced by the recycling cycles. The process is analogue to the industrial, starts from samples in pellets then a film by blow extrusion is obtained (odd steps) and posteriorly this film is recycled to pellets again (even steps). The results obtained show that the LLDPE samples develop two crystalline structures (CS1 and CS2) which evolve differently through the recycling cycles with a tendency to decrease in crystallinity due to degradation that is not the same for the process of obtaining film or recycling to pellet. The molecules with a more linear structure and a longer chain break and branch. The more branched structure increases and tends to crosslinking. This leads to a decrease in tear strength in the longitudinal direction, which is not so evident in the transversal direction. The samples could admit four recycling cycles with and acceptable tear resistance. The longitudinal tear strength value decreases by 40% for each film and 20% in the case of tearing in the transverse direction. The results obtained in this research work show that the regulations included in the cited circular economy package can be applied in the manufacture of consumer bags, helping also to reduce the dependence of manufacturers on fluctuations in delivery by collapses in shipping.
Study on Performance of Locomotive Diesel Engine Fueled with Biodiesel Using Two Miller Cycle Technologies
Authors: Jiang Feng , Zhou Junming , Hu Jie , Tan Xueyou , Cao Wentong , Tan Zedan
Published: February 2022

In this paper, the simulation model was established based on GT-Power software, and a scheme using the Miller cycle based on biodiesel was proposed. Taking diesel engine 16V265H as the research object, the accuracy of the simulation model was verified by experiments. Combined with the comparison of physical and chemical characteristics of biodiesel and the experimental analysis of biodiesel under three different combinations, it was concluded that low ratio biodiesel was the best choice to meet the power, economy, and emission performance of diesel. Through the simulation scheme of the two Miller cycles for pure diesel (B0) and biodiesel (B10) under different load conditions at 1000 rpm, the NOx emission performance of pure diesel in a Miller cycle was significantly improved. On this basis, the comprehensive performance of the two Miller cycles was compared with biodiesel. The results showed that both the Miller cycles could reduce NOx emission. Combined with other key performances of a diesel engine, the best scheme to improve the performance of the diesel engine was to burn B10 biodiesel and overlap angle the Miller cycle of the variable valve at 30 °CA. The scheme has guiding significance for the application of the 16V265H diesel engine.
Radioactive Elements Detected in Abandoned Oil Tank Farms
Authors: Petrache Stefan , Chis Timur , Sterpu Ancaelena Eliza , Săpunaru Olga Valerica
Published: February 2022

Oil fields in Romania were active in the period 1900–2020, some of which will close due to declining oil production and especially due to reduced processing after the application of European Community recommendations to give up fossil fuels and the use of renewable fuel. The rehabilitation of the soil affected by hydrocarbon pollution is carried out with public funds. This is why, when transferring the land to the local community, an oil pollution assessment study is carried out. If the hydrocarbon content is less than 1000 mg/kg dry matter, the soil is not depolluted. In the Moinesti oil area, Romania, against the background of the increased incidence of breast cancers in women who worked in oil facilities, a study was conducted on the natural radioactivity of abandoned oil areas. The results of this analysis are presented and discussed in this article. It is the first study of radioactivity of the oil tank farm affected by oil pollution, its purpose being to draw attention in detecting radioactive elements when handing over land affected by oil pollution (but which respects the maximum levels of pollutant) to the local community.
High-Resolution Canopy Height Model Generation and Validation Using USGS 3DEP LiDAR Data in Indiana, USA
Authors: Oh Sungchan , Jung Jinha , Shao Guofan , Shao Gang , Gallion Joey , Fei Songlin
Published: February 2022

Forest canopy height model (CHM) is useful for analyzing forest stocking and its spatiotemporal variations. However, high-resolution CHM with regional coverage is commonly unavailable due to the high cost of LiDAR data acquisition and computational cost associated with data processing. We present a CHM generation method using U.S. Geological Survey (USGS) 3D Elevation Program (3DEP) LiDAR data for tree height measurement capabilities for entire state of Indiana, USA. The accuracy of height measurement was investigated in relation to LiDAR point density, inventory height, and the timing of data collection. A simple data exploratory analysis (DEA) was conducted to identify problematic input data. Our CHM model has high accuracy compared to field-based height measurement (R2 = 0.85) on plots with relatively accurate GPS locations. Our study provides an easy-to-follow workflow for 3DEP LiDAR based CHM generation in a parallel processing environment for a large geographic area. In addition, the resulting CHM can serve as critical baseline information for monitoring and management decisions, as well as the calculation of other key forest metrics such as biomass and carbon storage.