bluuebunny/crossref_metadata_2025 huggingface dataset:
Ethnomathematics in Javanese Death Commemoration
Authors: Sari Nurul Husnah Mustika , Fahmy Ahmad Faridh Ricky
Published: May 2022

In Java, there is a tradition called death commemoration. In Javanese society, death commemoration consists of geblag (commemoration afther funeral), commemoration at 3rd day of the death, 40th day of the death, 100th day of the death, 1 year, 2 years, and 1000th day of the death. This was a descriptive research. It used ethnography method. The data was collected by interview, observation, and literature study. The result said that to decide the day and pasaran of death commemoration, it is need to use modulo concept. We used modulo 7 to decide the day, because there are seven days in a week and to decide the pasaran we used modulo 5 because there are five pasarans. It means that death commemoration tradition in Javanese society applied mathematical concept. Then, death commemoration tradition in Javanese is a part of ethnomathematics.
IRNSS Performance Evaluation of SPS Services on Military Aircraft
Authors: Chauhan Saurabh Singh
Published: May 2022

The essence of this paper is to study and characterise the performance of Indian Regional Navigation Satellite System (IRNSS), also known as NavIC (Navigation with Indian Constellation), in actual dynamic environment by conducting field trials on military aircraft. The dynamic accuracy of IRNSS receiver in terms of position, velocity and altitude has not yet been tested on any aircraft system i.e. commercial or military applications. These field trials and performance evaluation will help in on-field assessment of IRNSS receiver performance with availability of five, six and seven IRNSS satellites. During conduct of trials, IRNSS receiver and IRNSS antenna were placed inside the aircraft. Results analysis of 18 hours flying data depicts position availability of 99.872% with five satellites and 100% position availability with six and seven satellites.
Optimal Design of Multilayered Radar Absorbing Structures (RAS) using Swarm Intelligence based Algorithm
Authors: Joy Vineetha , Padwal Vishal , Nair Raveendranath U , Singh Hema
Published: May 2022

The steady progress in the fields of material science and processing technologies has made multi-layered radar absorbing structures (RAS) an attractive option w.r.t. stealth technologies. They possess the ability to reduce radar cross-section with minimum thickness and is therefore most preferred in airborne applications. As far as their electromagnetic performance is concerned, the sequence of material layers and thickness profile plays a pivotal role. Optimization of these two factors becomes complex in case of availability of large number of potential materials. Commonly used EM simulation software can be employed for the optimization of thickness profile. However, selection of suitable material layer sequence is out of their scope. In this context, a particle swarm optimization (PSO) based algorithm is presented for sequencing of material layers and optimization of thickness profile of multi-layered RAS configurations. The fitness function has been appropriately formulated to achieve maximum power absorption over broad band of frequencies and wide range of incident angles. Further, the efficacy of the algorithm has been demonstrated using a suitable case study.
Flight Planning Tool an Aid for Efficient Flight Evaluation
Authors: Saha Sukhen , Maida Antim , Rajesh R , Sharma Reena , Easwaran M S
Published: May 2022

Airborne surveillance systems have multiple sensors and communication links on board a suitable platform. They work in a cohesive manner to provide effective surveillance over the region of interest. The performance proving of such a system is challenging and requires flight trails extending over years. The test results often have to be interpreted using statistical analysis of the flight test data. An efficient way is to carefully design the flight test profiles such that enough samples can be collected during the test and multiple requirements can be tested in a single sortie. Such meticulous test strategies where both own ship platform and test targets are moving with high dynamics call for software based tool for planning of test sorties and the test points. Flight Planning Tool (FPT) plays an important role in pre-flight stage during developmental trials for analysis of the MOEs and MOPs of overall system and of various on-board sensors of an airborne multi-sensor system. The FPT provides statistical & graphical analysis for sensor behaviour for various scenarios (flight trials) before actual flight test is conducted. It provides prior information on number of valid samples for sensor testing during flight trials. In addition, the tool aids in assessing number of profiles to be flown for proving each MOE. The profiles can also be optimised such that valid samples are collected for evaluation.
Novel Attitude Estimation Of Strapdown Inertial Navigation Systems With Singular Value Decomposition Technique
Authors: Naidu Sivasubramaniam Nambi , Gupta Ramesh Kumar
Published: May 2022

Davenport’s q method & the Singular Value Decomposition (SVD) method are the two vigorous estimators that reduces Wahba’s loss function. In these, the q method is slightly quicker due to its computation of optimum quaternion as an eigenvector of a symmetric 4x4 matrix through the prevalent eigenvalue. The ESOQ and ESOQ2 (EStimators of the Optimal Quaternion) and the QUEST (QUaternion ESTimator) algorithms are less determined as the extreme eigenvalue’s distinguishing polynomial equation is solved by them. These estimators are apt to track the undulations of the sea with equivalent precision and accurateness. The SVD method is chosen and shown to be the most robust of all the hostile methods for the orientation of SDINS (Strap-Down Inertial Navigation Systems) using rate matching observations at sea in this paper. SVD is known most robust decomposition of all the decompositions of a matrix. SVD based attitude estimation being a batch technique would suffer from much less computational issues.
An Optimized SWCSP Technique for Feature Extraction in EEG-based BCI System
Authors: Ghumman Navtej S. , Jindal Balkrishan
Published: May 2022

Brain-computer interface (BCI) is an evolving technology having huge potential for rehabilitation of patients suffering from disorders of the nervous system, besides  many other nonmedical applications. Multichannel electroencephalography (EEG) is widely used to provide input signals to a BCI system. Significant research in methodology employed to implement different stages of BCI system, has led to discovery of new issues and challenges. The raw EEG data includes artifacts from environmental and physiological sources, which is eliminated in preprocessing phase of BCI system. It is then followed by a feature extraction stage to isolate a few relevant features for further classification to a particular motor imagery (MI) activity. A feature extraction approach based on spectrally weighted common spatial pattern (SWCSP) is proposed in this paper to improve overall accuracy of a BCI system. The reported literature uses SWCSP for feature extraction, as it has outperformed other techniques. The proposed approach enhances its performance by optimizing its parameters. The independent component analysis (ICA) method is used for detection and removal of irrelevant data, while linear discriminant analysis (LDA) is used as a classifier. The proposed approach is executed on benchmark data-set 2a of BCI competition IV. It yielded classification accuracy of 70.6% across nine subjects, which is higher than all the reported approaches.
Variasi Konsentrasi Kitosan Dan Lama Pengadukan Terhadap Efektivitas Penyerapan Amoniak
Authors: Oktavia Nadya , Supriyantini Endang , Ridlo Ali
Published: May 2022

Tumpahan minyak mentah di laut akan menimbulkan pencemaran karena memiliki kadar pencemar, salah satunya adalah amoniak. Kitosan merupakan biopolimer alami yang memiliki gugus aktif amina dan hidroksil yang dapat dibentuk sebagai adsorben amonia. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas kitosan dalam menyerap amoniak dengan air tercemar minyak mentah di sungai Karawang. Cairan kitosan yang digunakan terdiri dari (kontrol, 0%); (A) 0,3%; (B) 0,6%; (C) 0,9%; (D) 1,2%. Variasi waktu pengadukan yang digunakan adalah 30 menit dan 60 menit dengan kecepatan pengadukan 200 rpm dengan 3 kali pengulangan. Hasil penelitian menunjukkan bahwa perlakuan dengan variasi konsentrasi kitosan tersebut dapat meningkatkan daya serap kadar amoniak. Penyerapan tertinggi pada waktu pengadukan 30 menit terdapat pada konsentrasi kitosan 0,3% yaitu sebesar 8,709 mg/L dengan daya serap 92, 293 %, dan penyerapan tertinggi pada waktu pengadukan 60 menit terdapat pada konsentrasi kitosan 0,3% yaitu sebesar 8,735 mg/L dengan daya serap 92,566%. Konsentrasi kitosan dan variasi waktu pengadukan yang digunakan dalam penelitian ini berpengaruh nyata terhadap kapasitas dan daya serap terhadap amoniak.  The spills of crude oil on the ocean will cause pollution because it has pollutant levels, one of them is ammonia. Chitosan is a natural biopolymer which has got active group of amine and hydroxyl , they  can be formed as ammonia adsorbents. The purpose of this research is to find out the effectiveness of chitosan in absorbing the ammonia with crude oil contamined water in Karawang river. The liquid  of chitosan which is used consists of (Control, 0%); (A) 0.3%; (B) 0.6%; (C) 0.9%; (D) 1.2%. The variation of Stirring time that is used was 30 minutes and 60 minutes with a stirring speed of 200 rpm with 3 repetitions. The results showed that the treatment with those variation in the concentration of chitosan can increase the absorption capacity of ammonia levels. The highest absorption at the stirring time of 30 minutes was found at the concentration of 0,3 %,which was 8,709 mg/L with an absorption capacity of 92,293 %, while the highest absorption  at the stirring time of 60 minutes was found at the concentration of 0.3% chitosan which was 8,735 mg/L with 92,566 % absorption. The concentration of chitosan and the variation of stirring time used in this study significantly affected the capacity and absorption of ammonia.
Analisis Tinggi Gelombang Signifikan Berdasarkan Model Wavewatch-III di Pantai Alau-Alau, Kalianda, Lampung Selatan
Authors: Putri Annisa Agustina Kurnia , Diansyah Gusti , Putri Wike Ayu Eka
Published: May 2022

Perairan Pantai Alau-Alau merupakan daerah pesisir yang dimanfaatkan sebagai kegiatan pariwisata dan juga kegiatan perikanan seperti bagan perahu. Peramalan tinggi gelombang sangat berguna untuk menghindari kejadian kecelakaan kapal ataupun hantaman ombak besar di sekitar kawasan pantai. Tujuan dari penelitian ini adalah untuk menganalisis tinggi gelombang signifikan di wilayah Pantai Alau-Alau, Kalianda, Lampung Selatan dan menganalisis tingkat akurasi model Wavewatch-III BMKG (Badan Meteorologi Klimatologi dan Geofisika) dengan data lapangan. Data dari Model Wavewatch-III divisualisasi menggunakan software GrADS, lalu dibandingkan dengan data pengukuran lapangan yang dilaksanakan selama 7 hari (20-26 November 2019). RMSE (Root Mean Square Error) digunakan untuk melihat akurasi dari model tersebut. Hasil penelitian pengukuran lapangan menunjukkan tinggi gelombang signifikan di Pantai Alau-Alau berkisar 0,082-0,405 meter. Hasil tinggi gelombang signifikan hasil model Wavewatch-III berkisar 0,027–0,118 meter. Hasil nilai RMSE model Wavewatch-III terhadap data lapangan sebesar 0,28.   Alau-Alau Beach is a coastal area that used for tourism and fishery such as boat lift net. The forecast of wave height is very useful to avoid hitting big waves around coastal areas. The aims of this study are to analyze the significant wave height in the Alau-Alau Beach area, Kalianda, South Lampung and to analyze the accuracy of the Wavewatch-III BMKG (Climatology and Geophysics Meteorological Agency) with field data. Data of Wavewatch-III Model was visualized by using GrADS software, then compared it with field measurement data that was carried out for 7 days (20-26 November 2019). RMSE (Root Mean Square Error) was used in seing the accuracy of the model. The results from the field measurement showed that significant wave heights at Alau-Alau Beach ranged from 0.082 to 0.405 meters. The significant wave height from the Wavewatch-III model ranged from 0.027 to 0.118 meters. The results from the RMSE Wavewatch-III model on field data was 0.28.
Status Cemaran Logam Berat di Sedimen Muara Sungai Musi Sumatera Selatan
Authors: Putri Wike Ayu Eka , Susanti Mei Ida , Rozirwan Rozirwan , Hendri M. , Agustriani Fitri
Published: May 2022

Muara Sungai Musi merupakan perairan yang dipengaruhi oleh berbagai macam aktivitas manusia yang terdapat di sepanjang aliran Sungai Musi dan Sungai Telang serta kawasan muara itu sendiri. Ragam aktivitas ini berpotensi menimbulkan pencemaran di lingkungan perairan salah satunya adalah pencemaran logam berat. Tujuan penelitian ini adalah menganalis tingkat pencemaran logam berat Pb, Cu dan Zn di sekitar Muara Sungai Musi. Penelitian ini dilakukan pada bulan Agustus 2020, pengambilan sampel sedimen dilakukan pada enam titik stasiun dengan menggunakan metode purposive sampling. Konsentrasi logam berat dianalisis menggunakan Atomic Absorption Spectroscopy (AAS) merujuk pada SNI No. 06-6992.5-2004 untuk logam Cu, SNI No. 06-6992.3-2004 untuk logam Pb dan SNI No. 06-6992.8-2004 untuk logam Zn. Hasil penelitian menunjukkan bahwa konsentrasi rata-rata logam berat di sedimen Muara Sungai Musi berkisar antara 2,673 - 12,517 µg/g Pb, 1,927 - 5,9 µg/g Cu, 25,257 - 54,43 µg/g Zn. Kualitas sedimen dalam kategori baik dan aman bagi kehidupan biota di ingkungan Muara Sungai Musi karena rendahnya kontaminasi logam berat (Pb, Cu, Zn). Tingkat pencemaran logam berat Pb, Cu dan Zn di Perairan Muara Sungai Musi dalam kategori rendah dan tidak tercemar (I_geo<0), terkontaminasi rendah sampai sedang (Cf<1 sampai 1<Cf<3), serta tidak tercemar (PLI<1).  Musi River Estuary is waters that are influenced by various kinds of human activities originating from settlements, Musi River, Telang River and Bangka Strait causing pollution in the aquatic environment including heavy metal pollution. The purpose of this study was to analyze the level of heavy metal pollution Pb, Cu and Zn around the mouth of the Musi River. This research was conducted in August 2020 and sediment sampling was carried out at six stations using a purposive sampling method. Heavy metal concentrations were analyzed using Atomic Absorption Spectroscopy (AAS) refer to SNI No. 06-6992.5-2004 for Cu, SNI No. 06-6992.3-2004 for Pb and SNI No. 06-6992.8-2004 for Zn.. The results showed that the average concentration of heavy metals ranged from 2,873 – 12,51 µg/g Pb, 1,927 - 5,9 µg/g Cu, 25,257 - 54,43 µg/g Zn. The quality of the sediment is in the good and safe category because of the low contamination of heavy metals (Pb, Cu, Zn) for the life of biota in the Musi River Estuary Environment. The level of heavy metal pollution Pb, Cu and Zn in the Musi River Estuary is in the low category and not polluted (I_geo<0), low to moderate contamination (Cf<1 to 1<Cf<3), and not polluted (PLI<1).
Die Kund*innen im Mittelpunkt
Authors: Büchel Claudia
Published: May 2022

Eine Gruppe Öffentlicher Bibliotheken in Nordrhein-Westfalen tat sich 2001 unter Leitung der Staatlichen Fachstellen zusammen, um sich intensiv mit dem Thema Qualitätsmanagement zu beschäftigen. 2006 erfolgte die Erstzertifizierung durch den TÜV-Süd nach ISO 9001. Der Verbund ist zwar deutlich geschrumpft, doch zwei der Erstgründerbibliotheken sind weiterhin aktiv und ISO-zertifiziert und können sich einen Alltag ohne ein Qualitätsmanagement-System nicht mehr vorstellen.
„Nicht nur Bücher haben ihre Schicksale, sondern auch ihre Leser“
Authors: Kummer Stephan
Published: May 2022

Der Aufsatz skizziert das Provenienzforschungsprojekt in den judaistischen Altbeständen der Universitätsbibliothek der Freien Universität Berlin, das im November 2021 begonnen hat. Ziel des Projekts ist es, die Provenienzspuren zu identifizieren, zu dokumentieren, die Wege der Bücher und das Schicksal ihrer Leserschaft zu erforschen. Neben einer Genese über die Gründung und Etablierung des Instituts für Judaistik widmet sich der Hauptteil des Beitrages dem Workflow. Für die Präsentation des Arbeitsalltages dienen zwei ausgewählte und abgeschlossene Fallbeispiele aus der Projektarbeit.
Retrokonversionsprojekt von 35.000 Zettelkarten der Musikbibliothek der Leipziger Städtischen Bibliotheken
Authors: Aring Annalena , Müller Jane , Wallwitz Sebastian
Published: May 2022

Im Rahmen der Erfassung des Kunst- und Kulturguts der Stadt Leipzig wurden im Jahr 2021 insgesamt 35.000 Zettelkarten der Leipziger Städtischen Bibliotheken digitalisiert und im Metadatenformat MARC-XML in das Bibliotheksmanagementsystem importiert. Das Retrokonversionsprojekt startete mit einer umfangreichen Testphase und anschließender effizienter Projektarbeit, um das Ziel zu erreichen, die musikspezifischen historischen Bestände der Bibliothek online zu verzeichnen. In dem Projekt wirkten die Sachgebiete Musikbibliothek/Sondersammlungen, Katalogisierung sowie Digitales und IT zusammen mit Dienstleistern aus Leipzig und Vietnam.
The effect of advocacy education of nursing students on attitudes towards disability: a quasi-experimental study
Authors: Demirören Nesime , Su Serpil , Basit Gülden
Published: May 2022

Objectives

To determine the effect of advocacy education on the attitude of nursing students towards persons with disabilities.

Methods

This study is a one-group pretest-posttest design: a quasi-experimental study. The study population consisted of 38 students who were enrolled in the advocacy course in the final year of nursing school in a public university. A ten-week Disability Advocacy Education Program was implemented. Data was collected using the Data Sheet and Multidimensional Attitudes Scale Toward Persons with Disabilities.

Results

Male students were found to have higher mean scores after the education; there was no statistically significant difference for other variables such as family structure, place of residence, and whether they have received education on disabilities.

Conclusions

Nursing students have a positive attitude towards people with disabilities, and that male students’ attitudes improved after education.

Implications for International Audience

Advocacy education provided to students help them develop a positive attitude towards people with disabilities.
Crystal structure of the double salt bis(5-amino-1,2,4-triazol-4-ium-3-yl)methane hydrogen oxalate hemioxalate, C8H11N8O6
Authors: Zhang Guo-tao , Wang Hua , Li Hong-ya , Yan Biao
Published: May 2022

C8H11N8O6, monoclinic, P21/n (no. 14), a = 5.6348(8) Å, b = 19.485(3) Å, c = 11.5316(17) Å, β = 101.013(2)°, V = 1242.8(3) Å3, Z = 4, R
gt(F) = 0.0396, wR
ref(F
2) = 0.1039, T = 296(2) K.
Dynamic characterization of the magnetomechanical properties of off axis anisotropic magnetorheological elastomer
Authors: Walid Bendjeddou , Salah Aguib , Noureddine Chikh , Abdelkader Nour , Toufik Djedid , Lallia Kobzili , Mounir Meloussi
Published: May 2022

The use of magnetorheological elastomers in the mechanical and acoustic fields, by the automotive, aeronautical, and building industries, is currently developing strongly and rapidly. The perfect understanding of the capacity of smart insulation based on the absorption of the vibratory waves by magnetorheological elastomers materials passes by the knowledge of their dynamic mechanical behavior. In this present work, we have characterized the dynamic mechanical properties of the magnetorheological elastomer off axes anisotropy by the inclination, of different angles (15°, 30°, and 45°), of the pseudo-fibers of the iron particles formed by the application of a magnetic field at different intensities using an optimal loading rate of 30%. The rubber specimens were prepared by mixing micron-sized iron particles dispersed in room temperature vulcanized (RTV) silicone rubber by solution mixing. The experimental results obtained show a clear dependence of the effect of inclusion of ferromagnetic chains on the magnetomechanical properties. It is observed that the mechanical properties are better when applying a magnetic field of 0.6 T with an angle of inclination of 45°. The improvements added in this work could be useful in several industrial applications, such as automotive, aeronautic through adaptive control of damping and vibration level.
Asymptotic behavior of solutions to the three-dimensional stochastic Leray-α model
Authors: Thanh Nguyen Van , Tuan Tran Quoc
Published: May 2022

We consider the three-dimensional stochastic Leray-α model with homogeneous Dirichlet boundary conditions and infinite-dimensional Wiener process. We first study the mean square and pathwise exponential stability of a stationary solution to the model. Then we show that one can stabilize an unstable stationary solution by using a multiplicative Itô noise of sufficient intensity or a linear internal feedback control with support large enough.
Bayesian Switching Volatility Models for Analysing Stock Returns in Ghana
Authors: Akurugu Edward , Angbing Irene Dekomwine , Nasiru Suleman , Abubakari Abdul Ghaniyyu
Published: May 2022

The goal of this research was to use Bayesian switching volatility models to model the stock returns of the GCB, bank in Ghana. Monthly stock prices of GCB bank for the period of 138 months were used for the study. The two-state Markov-Switching GARCH models were used in the study to determine the best model for modelling and forecasting the stock returns. The Deviance Information Criteria was considered when selecting the best model. Based on the Deviance Information Criteria, E-GARCH variance specification with skewed student-t innovation was shown to be appropriate for modelling the stock returns. The estimates of the best model showed the first regime to exhibit the features of “turbulent market conditions” while the second regime exhibits “tranquil market conditions”. The risk analysis finds the best model to generally perform better in estimating both Value-at-Risk and Expected Shortfall at 1% rather than 5%. The study advises investors to invest in GCB bank because of the high returns connected with the stock and the fact that when “turbulent market conditions” arise, the recovery rate for these stocks is faster.
Interfacial catalytic materials; challenge for inorganic synthetic chemistry
Authors: Schlögl Robert
Published: May 2022

Interfacial catalysts are indispensable functional materials in the energy transformation. The traditional empirical search strategies reach their potential. Knowledge-based approaches have not been able to deliver innovative and scalable solutions. Following a short analysis of the origin of these shortcomings a fresh attempt on the material challenge of catalysis is proposed. The approach combines functional understanding of material dynamics derived from operando analysis with digital catalysis science guiding the exploration of non-linear interactions of material genes to catalytic functions. This critically requires the ingenuity of the synthetic inorganic chemist to let us understand the reactivity of well-defined materials under the specific conditions of catalytic operation. It is the understanding of how the kinetics of phase changes brings about and destroys active sites in catalytic materials that forms the basis of realistic material concepts. A rigorous prediction and engineering of these processes may not be possible due to the complexity of options involved.
Probiotics and Gut Microbiota: The Underlying Helpers of Health
Authors: Binger Andrew
Published: May 2022

As per the amount of time that bacteria spend living and growing in the intestine, we can divide them into two categories: long-term (also called permanent residents) and transitory (also called alien). According to the findings of previous research, a dysbiosis of the microbiota in the gut may be linked to a wide variety of human illnesses. Microorganisms that are considered to be living, such as bacteria, are known as probiotics. When given to a host in adequate quantities, probiotics can be beneficial. There is compelling evidence that probiotics have a positive impact on health, but this area of research has to be expanded.
An Evidence-Based Review of Probiotics and Prebiotics
Authors: Jung Hye Young , Kim Kwang Wook
Published: May 2022

Probiotics and prebiotics have a variety of beneficial effects on the host’s health. Extensive studies have established probiotic strains such as Lactobacillus and Bifidobacterium, and further the concept of next-generation probiotics has been advocated. Clinical trials and mechanism of action research have demonstrated that the gut microbiota and host health are inextricably linked, and that probiotics can benefit intestinal-related disorders such as inflammatory bowel disease by controlling the gut microbiota. Accordingly, the host’s gut microbiota has the greatest direct effect on the efficiency of probiotics and prebiotics. Due to the highly individualized gut microbiota, supplementation with probiotics and prebiotics must take the host’s gut microbiota into account. Personalized and specific interventions, as well as the development of next-generation probiotics, will be the new focus of research.
Low-Density Resin-Based Ablative Heat Protection Materials
Authors: Willard Johnson M.
Published: May 2022

The severe aerodynamic heating that occurs when a spacecraft reenters the atmosphere takes place. The material used for thermal protection is an essential part of the system used for thermal protection. A number of chemical and physical transformations take place in the ablation heat-resistant material that is based on resin. This material is an organic polymer. We herein briefly review the status quo of low-density resin-based ablative heat protection materials.
The Role of Information Technology-assisted Instruction and its Implementation Strategies
Authors: Wang Junwen
Published: May 2022

As a result of the rapid advancement of information technology (IT), the integration of IT into classroom learning has become a major topic of discussion in the education community. It is widely acknowledged as an effective method for optimizing teaching effectiveness and student learning efficiency. This paper’s objective is to assess the current situation of IT-assisted classroom instruction in China and to offer practical suggestions.
Cirugía plástica periodontal con uso de injertos de tejido conectivo en recesiones
Authors: Panchi Lasluisa Jonathan Andrés , Molina Gallegos Carlos Francisco , Molina Dávila Carlos Andrés , Armas Vega Ana del Carmen
Published: May 2022

La cirugía plástica periodontal es una alternativa para recubrir las superficies radiculares expuestas por recesiones gingivales, devuelve la estética y mantiene la dentición completamente funcional durante la vida del paciente. El objetivo de la presente revisión fue presentar mediante una revisión narrativa la eficacia de la cirugía periodontal con uso de injertos de tejido conectivo en el tratamiento de recesiones gingivales clase I y II de Miller. De la búsqueda en la base de datos PubMed entre los años 2015 y 2022 donde se obtuvieron 364 artículos, tras verificar el cumplimiento de los criterios de inclusión y exclusión 47 artículos fueron analizados por completo. El uso de un colgajo desplazado coronalmente con injerto de tejido conectivo permite conseguir una alta eficacia de cobertura de las superficies radiculares expuestas, mostrando además un evidente éxito con 95% de cobertura total de la superficie radicular en colgajos desplazado lateralmente con injerto de tejido conectivo. La eficacia de la cobertura radicular en recesiones gingivales clase I y II de Miller es atribuida al uso de injertos de tejido conectivo combinados con un adecuado colgajo que permita la correcta irrigación del injerto.
Factores de riesgo que inciden en la reabsorción condilar posterior a cirugía ortognática. Revisión bibliográfica
Authors: Guerra Erazo Cristina Alexandra , Quisilema Cadena Michael Xavier
Published: May 2022

La reabsorción condilar (RC) después de una cirugía ortognática (CO) es una consecuencia no deseada y en ocasiones con complicaciones irreversibles. El propósito de la investigación fue determinar los factores de riesgo que inciden en la RC posterior a una CO, mediante una revisión bibliográfica. Para lo cual se planteó un estudio exploratorio y documental, se realizó una revisión de literatura de los artículos desde el periodo de 2000 hasta el 2020, sin restricción de idioma, se excluyeron las investigaciones en animales e in vitro, resúmenes de congresos, publicaciones de RC relacionadas por enfermedad sistémica y estudios sobre remodelación condilar sin especificar RC posquirúrgica. La búsqueda de información se efectuó entre julio-agosto del 2021, en las bases de datos de Pubmed, Embase y SciELO, inicialmente fue con los términos de RC, CO, reabsorción condilar progresiva, “RC y CO”, reportando 1346 artículos iniciales, después se hizo una selección de los estudios en función de los factores de riesgo, identificando 53 artículos, siguiendo los lineamientos de PRISMA. Se incluyeron 23 artículos, el análisis de los mismos demostró que los principales factores de riesgo implicados en la RC posquirúrgica son el sexo femenino de los pacientes, entre 14 y 58 años, con maloclusión clase Angle II, con ángulos del plano mandibular alto (24º- 50º), expuestos a una cirugía bimaxilar, avance mandibular (AM) mayor a 5 mm en sentido antihorario, utilizar una fijación intermaxilar rígida y que la recaída posquirúrgica se puede relacionar con la RC.
Tratamiento de sonrisa gingival con planificación digital. Reporte de caso
Authors: Castañeda Harold , Gutiérrez Rodolfo , Tapias Geraldine , Gonzalez Pierreangela
Published: May 2022

La sonrisa gingival (SG) es una condición clínica de etiología multifactorial, caracterizada por la sobreexposición de la encía maxilar, mayor de 3 mm, mientras el paciente sonríe. Es considerada una de las alteraciones más comunes en la población con una prevalencia de 10,5-29%, 7% en hombres y 14% en mujeres, en el grupo etário de 20-30 años. La literatura científica reporta diversos tratamientos quirúrgicos invasivos y mínimamente invasivos que pueden ser acompañados con planificación digital. El objetivo de este reporte de caso fue describir el tratamiento de SG por erupción pasiva alterada tipo I, subcategoría A e hipermovilidad de músculo elevador del labio superior, en paciente femenino corregido con procedimientos quirúrgicos y métodos conservadores como la toxina botulínica planificado digitalmente. El uso de planificación digital en la reducción de SG acompañada de técnicas conservadoras como toxina botulínica permiten realizar procedimientos con postoperatorios favorables, disminución en errores de la técnica con resultados predecibles, seguros, rápidos y consistentes de acuerdo a las expectativas del paciente.
CHARACTERISTICS OF WOUND INFECTIONS AND METHODS OF THEIR TREATMENT USING PREPARATIONS OF BIOLOGICAL ORIGIN
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Oliinyk A. V.
Published: May 2022

Surgical wound infections are the most common patients’ complications in the postoperative period. In the modern clinic, they worsen the disease prognosis and remain the most important and acute health problem in all countries of the world. The aim of the work was to analyze current scientific data on the peculiarities of the pathogenesis of wound infections and types of their pathogens, as well as drugs of biological origin in the treatment of wound infections. The paper discusses in detail the problem of infection of wound injuries during surgery and domestic injuries of various kinds. The main pathogens of wound infections are considered. Specific pathogenicity factors for bacteria of the genera Staphylococcus, Pseudomonas, Enterobacteriaceae were analyzed. Based on the analysis of literature sources, a list of drugs of biotechnological origin that can be effectively used in combination therapy for the treatment and prevention of wound infections was determined. Conclusions. The result is the identification of those mechanisms of pathogenesis of wound infections that determine the effectiveness of the use of drugs of biological origin in this pathology treatment.
ACTION OF VENOM OF VIPERA SNAKE OF UKRAINE ON BLOOD COAGULATION in vitro
Authors:   Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine, Kyiv, Iskandarov E. ,   Educational and Scientific Center “Institute of Biology and Medicine” of Taras Shevchenko National University of Kyiv, Ukraine
Published: May 2022

Aim. In this study we focused on the search of fibrinogen-targeted proteases in the venom of Vipera renardi, Vipera nikolskii and Vipera berus. Venom of Vipera berus was also fractionated on Q-sepharose and action of separated fractions on human blood plasma, platelets and red cells was studied. Methods. Analysis of protein mixtures was performed using SDS-PAGE. Аction on the blood coagulation system was analyzed using the APTT assay. Identification of protein components with fibrinolytic activity was performed using enzyme-electrophoresis with fibrinogen as the substrate. Fractionation of V. berus venom was performed on Q-sepharose using FPLC system Acta Prime. Action of separated fractions on ADP-induced platelet aggregation in platelet rich blood plasma was analyzed using Aggregometer AP 2110. Hemolytic action of fractions was estimated using fresh human red cells. Amount of released hemoglobin was estimated by spectrophotometry on Optizen POP. Results. All studied venoms had different protein compositions with major protein fractions in the range from 25 kDa to 130 kDa. Both V. berus and V. nikolskii venoms taken in 1:200 dilutions reduced the time of clotting in APTT test from 25 to 13 s. In contrast, V. renardi venom in the same dilution prolonged the clotting time from 25 s to 180 s that we assumed as the result of fibrinogen-specific protease presence. According to enzyme-electrophoresis data all studied venoms contained fibrinogen-specific proteases with the apparent molecular weights for V. berus, V. nikolskii – 25-55 kDa. and V. renardi – 55-75 kDa. Fractionation of crude venom of V. berus allowed obtaining several fractions eluted at different concentrations of NaCl: 0.1; 0.2; 0.3; 0.5 М. Non-binded fraction was also collected. Conclusions. Thus, the components of Vipera venoms living in Ukraine can be used for basic biochemical research. At the same time, care should be taken in the case of envenomation, as the presence of fibrinogenolytic enzymes in the venom can lead to hemorrhage. Further characterization of fibrinogen-specific protease from V. berus venom is a promising task for biotechnology.
INFLUENCE OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME ON THE DEVELOPMENT OF OXIDATIVE STRESS DURING SIMULATION OF CHRONIC ALCOHOL INTOXICATION IN RATS
Authors:   Poltava State Medical University, Ukraine, Mykytenko A. O.
Published: May 2022

The aim of our study was to analyze changes in the development of oxidative stress in the liver of rats with chronic alcohol intoxication against the background of systemic inflammatory response syndrome based on the study of catalase and superoxide dismutase activity, concentration of malonic dialdehyde, oxidatively modified proteins and sulfide anion and superoxide anion production. Methods. Experimental studies were performed on 12 male Wistar rats weighing 180‒220 g. Animals were divided into two groups: 1 ‒ control and 2 ‒ animals, on which we simulated alcoholic hepatitis and SIRS. The activity of catalase and superoxide dismutase (SOD), the concentration of malonic dialdehyde (MDA) , oxidatively modified proteins (OMP) sulfide anion and superoxide anion production were studied in the rat liver homogenate. The obtained results were subjected to statistical processing using the Mann-Whitney test. Results. Analyzing the development of oxidative stress in the liver of rats, on which we simulated the combined effects of SIRS and prolonged alcohol intoxication, we found that the activity of SOD increased by 1.72 times (P<0.05), and catalase decreased by 1.18 times (P<0.05) compared with the control group. The production of superoxide anion radical in the liver of rats increased 2.21 times (P<0.05) in the group of animals with combined exposure to bacterial LPS and alcohol intoxication compared to control. The concentration of MDA increased 2.25 times (P<0.05), and OMP by 9.5 times (P<0.05) compared with control group. The concentration of sulfide anion in the liver of rats under the conditions of modeling the combined effects of SIRS and alcohol intoxication decreased by 1.44 times (P <0.05) compared with the control. Conclusions. Modeling of alcohol intoxication against the background of systemic inflammatory response syndrome leads to oxidative damage to lipid and protein structures of the liver due to increased production of superoxide anion radical and imbalance of antiradical protection.
MOLECULAR BASIS OF THE DEVELOPMENT OF INSULIN RESISTANCE IN OBESE ADOLESCENT AND ADULT MEN
Authors:   Palladin Institute of Biochemistry, of the National Academy of Sciences of Ukraine, Kyiv, Viletska Y.
Published: May 2022

The aim of this work was to study the association between the expression of glucose metabolism related genes and insulin resistance, which expression is changed in obese adolescents and adult men with and without insulin resistance, for better understanding the molecular basis of the development of obesity complications and evaluation of possible contribution of these genes in development of insulin resistance. Methods. The expression level of genes related to glucose metabolism and their regulations was studied by real-time qPCR in adipose tissue and blood cells using SYBRGreen Mix and specific for each mRNA forward and reverse primers. Total RNA was extracted using TRIZOL reagent. For reverse transcription of mRNAs we used Thermo Scientific Verso cDNA Synthesis Kit (Germany). The values of mRNA expressions were normalized to the level of ACTB mRNA and represented as percent of control (100 %). Results. It was shown that in obese patients with insulin resistance the expression level of IRS1 (insulin receptor substrate 1), HK2 (hexokinase 2), PFKFB2 (6-phosphofructokinase/fructose-2,6-bisphosphatase 2) and PFKFB3 as well as circadian factors CLOCK and ARNTL genes in subcutaneous adipose tissue is significantly decreased as compared to obese men with normal sensitivity to insulin. At the same time, the development of insulin resistance in obese patients leads to up-regulation of PFKFB4, PER1, HSPA6, ALDH1A3, COL5A1, TIMP1, TIMP2, SPARC, and VCAN gene expressions in subcutaneous adipose tissue. The expression level of IGF1 (insulin-like growth factor 1) and IGFBP5 (IGF binding protein 5) as well as ENO1 (enolase 1) and ENO2 is down-regulated in the blood of obese adolescent with insulin resistance, but IGFBP2 and IGFBP7 gene expressions are significantly increased in these patients. Conclusions. The results of this investigation provide evidence that the development of insulin resistance in obese patients is associated with gene specific changes in the expression of many very important regulatory genes, which are endoplasmic reticulum stress responsible.
EPITHELIAL-MESENCHYMAL TRANSITION IN MELANOMA PROGRESSION: THE CONTRIBUTION OF ADAPTOR PROTEIN RUK/CIN85
Authors:   Taras Shevchenko National University, Ukraine, Kyiv, Zhuravel B. V.
Published: May 2022

The purpose of this study was to test the hypothesis that Ruk/CIN85 overexpression/knockdown in melanoma cells may be involved in the regulation of EMT. Materials and methods. The mouse melanoma cell line B16-F10 and its sublines with up-/down-regulation of Ruk/CIN85 (generated early using lentiviral technology) were used as a model for research. Melanoma cells were cultured in the complete RPMI 1610 medium under standard conditions. Proliferative activity of the cells was estimated using the MTT-test, and cell migratory potential was studied by the wound-healing assay. The data obtained were analyzed with parametric Student`s t-test. Results were expressed as mean ± SEM and significance was set at P<0.05. Results and Discussion. Cutaneous melanoma genesis is a multi-step process initiated by the transformation of a normal melanocyte following an oncogenic insult. Due to the transcriptome and metabolome reprogramming in the course of EMT, transformed melanoma cells change their phenotype and acquire increased proliferative rate, cell motility, invasiveness, and metastatic potential. According to the data obtained, overexpression of Ruk/CIN85 in B16 mouse melanoma cells (subclones Up7 and Up21) led to an increase in their proliferative activity by 1,6 and 1.8 times, respectively, at 24th hour in comparison with control Mock cells . At the 48th hour, when the cells reached confluence, the cell viability of subclones did not differ from the control ones. No statistically significant changes in the proliferative activity of B16 cells with suppressed expression of the adaptor protein (subclone Down) were found. In accordance with previous data, B16 cells overexpressing Ruk/CIN85 were characterized by strongly increased motility rate (more than twofold for both Up7 and Up21 subclones compared to control Mock cells). At the same time, knockdown of Ruk/CIN85 in B16 cells resulted in a decrease in their migratory activity by about 30%. Conclusions. All findings obtained demonstrated that the malignancy traits of melanoma B16 cells are inversely modulated upon up- and down-changes in adaptor protein Ruk/CIN85 expression levels suggesting its possible role in the control of EMT.
Transcriptional activity analysis of the immune response genes in the peripheral blood of patients with comorbid acute urticaria and lyme borreliosis
Authors:   I. Horbachevsky Ternopil National Medical University, Ukraine, Petruk A.M. , Kamyshna I.I. ,   I. Horbachevsky Ternopil National Medical University, Ukraine, Shkilna M.I. ,   I. Horbachevsky Ternopil National Medical University, Ukraine, Kamyshnyi A.M.
Published: May 2022

Acute urticaria (AU) and Lyme borreliosis (LB) are known to alter the transcriptional profile of blood cells. The nature of changes in the transcriptional activity of genes of the innate and adaptive immune system in the peripheral blood in patients with comorbid AU and LB is unknown. In our study, we applied a pathway-specific PCR array (Human Innate & Adaptive Immune Responses RT2 Profiler PCR Array, QIAGEN, Germany) to detect and verify the innate and adaptive immune responses of pathway-focused genes expression in the blood of patients with a comorbid course of these pathologies. It was found that in patients with comorbid AU and Lyme disease, transcriptional induction of a number of genes of the innate immune system in PBMC was observed, in particular: TLR2, NOD2, NLRP3, APCS, complement component 3 (C3), CD14, CD86 compared with patients suffering from acute urticaria. These changes were accompanied by an increased transcriptional activity of systemic proinflammatory cytokines IL1B, IL6, IFNG and its receptor IFNGR1, TNF, ligands, and chemokine receptors CXCL10, CXCR3, CCR5, tyrosine kinase JAK2 and transcription factors STAT1 and TBX21. At the same time, the comorbid course of acute urticaria and Lyme disease led to the repression of the transcriptional activity of the CD80, IL4, and CXCL8 genes. The comorbid course of acute urticaria and Lyme borreliosis is accompanied by activation of the transcriptional activity of genes of the innate immune system and proinflammatory cytokines.
Machine Learning Approach to Predicting Absence of Serious Bacterial Infection at PICU Admission
Authors: Martin Blake , DeWitt Peter E. , Scott Halden F. , Parker Sarah , Bennett Tellen D.
Published: May 2022

BACKGROUND AND OBJECTIVES

Serious bacterial infection (SBI) is common in the PICU. Antibiotics can mitigate associated morbidity and mortality but have associated adverse effects. Our objective is to develop machine learning models able to identify SBI-negative children and reduce unnecessary antibiotics.

METHODS

We developed models to predict SBI-negative status at PICU admission using vital sign, laboratory, and demographic variables. Children 3-months to 18-years-old admitted to our PICU, between 2011 and 2020, were included if evaluated for infection within 24-hours, stratified by documented antibiotic exposure in the 48-hours prior. Area under the receiver operating characteristic curve (AUROC) was the primary model accuracy measure; secondarily, we calculated the number of SBI-negative children subsequently provided antibiotics in the PICU identified as low-risk by each model.

RESULTS

A total of 15 074 children met inclusion criteria; 4788 (32%) received antibiotics before PICU admission. Of these antibiotic-exposed patients, 2325 of 4788 (49%) had an SBI. Of the 10 286 antibiotic-unexposed patients, 2356 of 10 286 (23%) had an SBI. In antibiotic-exposed children, a radial support vector machine model had the highest AUROC (0.80) for evaluating SBI, identifying 48 of 442 (11%) SBI-negative children provided antibiotics in the PICU who could have been spared a median 3.7 (interquartile range 0.9–9.0) antibiotic-days per patient. In antibiotic-unexposed children, a random forest model performed best, but was less accurate overall (AUROC 0.76), identifying 33 of 469 (7%) SBI-negative children provided antibiotics in the PICU who could have been spared 1.1 (interquartile range 0.9–3.7) antibiotic-days per patient.

CONCLUSIONS

Among children who received antibiotics before PICU admission, machine learning models can identify children at low risk of SBI and potentially reduce antibiotic exposure.
Combining Data Elements to Determine Amount and/or Complexity
Authors:   American Academy of Pediatrics
Published: May 2022

The tables included in this article provide examples of data types that may support the amount and/or complexity of data element of medical decision-making (MDM) for office and other outpatient evaluation and management (E/M) services provided in 2022.
Coding for Evaluation and Management Services Provided by Telephone
Authors:   American Academy of Pediatrics
Published: May 2022

This article addresses the CPT codes and instructions for reporting telephone E/M services.
New Category III Codes Effective July 2022
Authors:   American Academy of Pediatrics
Published: May 2022

This article lists services for which new codes will be effective for dates of service on and after July 1, 2022, and that may be provided to pediatric patients:
Critical Care Services: A Review of Code Categories (Online Exclusive)
Authors:   American Academy of Pediatrics
Published: May 2022

This article reviews the CPT criteria and code categories for reporting pediatric critical care.