bluuebunny/crossref_metadata_2025 huggingface dataset:
Dual target effect of hemiprotonic phenoline-phenoline+ on inhibiting metastatic breast cancer and concurrent candidiasis
Authors: Li Jingli , Zhao Zizhen , You Dongmei , Xie Yafang , Feng Yixiao , Li Xiaorong , Cui Zhihong , Fu Ailing
Published: February 2024

Background
Metastatic breast cancer is a challenge in clinical, and the frequent occurrence of concurrent infections in patients is a direct cause of patient death. However, there is no effective treatment to improve the survival rate and extend the survival period. Here we propose a dual target strategy to treat the cancer and concurrent candidiasis. Since hemiprotonic dimers generally have high biological activity, a chemical called hemiprotonic phenoline-phenoline+ (ph-ph+) was used in the study to explore the feasibility of dual target effect of anticancer and antifungus.
Methods
The metastasis of breast cancer cells were detected by transwell migration and invasion assay, as well as cell scratch assay. The fungicidal effect of ph-ph+ was evaluated by MIC and MFC. The targets were identified by pPLAGL2 transfection and caseinolytic peptidase P (CLpP) activity determination. The animal model of experimental metastatic breast cancer combined with candidiasis was prepared to prove the anticancer and antifungal effect.
Results
The results showed that ph-ph+ could suppress the proliferation and metastasis of breast cancer cells, and meanwhile kill Candida albicans (C. albicans) effectively. The mechanism of antifungus and anticancer of ph-ph+ was associated with the activation of an evolutionarily conserved protease CLpP. Also, ph-ph+ could inhibit the signaling pathway mediated by PLAGL2 that highly expressed in cancer cells, thereby participating in preventing cell metastasis and inducing apoptosis. In experimental animal model, ph-ph+ retarded the growth and metastasis of the cancer cells, and eliminate C. albicans in tissues at the same time.
Conclusions
The result suggests that CLpP and PLAGL2 as dual targets could be an potential approach against metastatic cancer and pathogenic fungus, and identifies the effectiveness of ph-ph+ as the dual target inhibitor.
Lower parasite pressure in invasive freshwater bivalves than in sympatric native Unionidae mussels in southern European lakes
Authors: Deng Binglin , Nicoletta Riccardi , Urbańska Maria , Marjomäki Timo , Andrzejewski Wojciech , Taskinen Jouni
Published: February 2024

Enemy Release Hypothesis (ERH) proposes that the success of bioinvasions is contributed by lower enemy pressure on invasive species compared to native ones, giving a competitive advantage for invaders. In line with EHR, we earlier observed that the invasive bivalves had a lower parasite pressure than the sympatric native freshwater mussels in northern European waterbodies. Here, we investigated ERH in three southern European lakes, where the native mussels are rapidly declining and replaced by exotic bivalves. Examination of 679 bivalves (n of individuals per species per lake varying from 12 to 187) collected 2016-18 revealed in total 11 parasite taxa. On average, 2.6 times higher number of parasite taxa and 3.4 times higher sum of infection prevalences was observed per lake among the native mussels (Anodonta exulcerata, A. cygnea, A. anatina and Unio elongatulus) than in the sympatric invasive bivalves (Dreissena polymorpha, Corbicula fluminea and Sinanodonta woodiana). Notable was the complete lack of parasites from C. fluminea. Thus, results supported ERH and were in accordance with previous results from northern Europe, suggesting, on average, a lower parasite pressure in invasive bivalves than in sympatric native mussels. This may contribute to the observed successful invasion of exotic freshwater bivalves in Europe.
A robust optimisation genetic algorithm for HDR prostate brachytherapy including all major uncertainties II: Algorithm evaluation on 49 patients
Authors: Kennedy Andrew C. , Douglass Michael J. J. , Gowda Raghavendra V. , Santos Alexandre M. C.
Published: February 2024

Introduction:
Treatment plans in high-dose-rate (HDR) prostate brachytherapy (BT) are currently optimised to meet clinical objectives in the nominal plan; however, uncertainties cause the scenario delivered to deviate from this plan and may fail objectives. A robust optimiser generates plans that maximise the probability of dose-volume-histogram (DVH) metrics passing in the delivered scenario.
Method:
A probabilistic robust optimiser was evaluated on 49 patients. Three objective functions were maximised to obtain the Pareto front consisting of 200 robust-optimised treatment plans. Each objective function approximated the robustness of three DVH metrics: (1) the minimum dose to the hottest 90% of the prostate, \({\text{D}}_{90}^{\text{P}}\), the maximum doses to the (2) urethra, \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\), and (3) rectum, \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\). Pareto front plans were robustly evaluated using 1000 probabilistic uncertainty scenarios, outputting the pass-rates for \({\text{D}}_{90}^{\text{P}}\), \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\), \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\), and all three simultaneously, the overall pass-rate. The best robust-optimised plan was selected from the Pareto front and compared to the TPS-optimised plan for ten patients by a radiation oncologist, then 49 patient robust-optimised plans were compared.
Results:
All robust-optimised plans had higher overall pass-rates (mean: 50.7 ± 1.5%, SD: 14.2%) compared to the TPS-optimised plans (mean: 32.0 ± 1.5%, SD: 12.3%). This was also the case with the \({\text{D}}_{0.01 \text{c}\text{c}}^{\text{U}}\) pass-rates with the robust-optimised plans having a mean of 66.0 ± 1.3% (SD: 12.1) compared with 47.2 ± 1.3% (SD: 9.3%). The pass-rates for \({\text{D}}_{90}^{\text{P}}\) were higher for the robust-optimised plans (mean: 85.6 ± 1.1%, SD: 9.5%) in 36 patients, the TPS-optimised mean was 82.2 ± 1.1% (SD: 13.8%). Twenty-seven patients had higher \({\text{D}}_{0.1 \text{c}\text{c}}^{\text{R}}\) pass-rates in the robust-optimised plans with a mean of 94.54 ± 0.56% (SD: 7.35%) compared with 93.71 ± 0.56% (SD: 6.73%).
Conclusion:
A robust optimisation algorithm generated treatment plans with higher robustness than the TPS-optimised plans for nine out of ten patients, evaluated by a radiation oncologist, in an average time of 1-minute-49-seconds.
Can gallbladder cancer patients experience benefits from marriage? A competing risk analysis in a real-world context
Authors: Jin Haimin , Du Danwei , Xie Yangyang , Jin Haijuan , Tong Jinfei , Li Binbin , Chu Weijian
Published: February 2024

Background: The association between marital status and gallbladder cancer (GBC) remains uncertain. This study aimed to verify the relationship between marital status and GBC and construct a prognostic nomogram to predict the impact of marital status on GBC patients.
Method: GBC patients were split into married and unmarried groups and added to the Surveillance, Epidemiology, and End Results (SEER) database. We employed competing risk analyses, propensity score matching (PSM), and Kaplan-Meier survival analyses. After that, the relationship between marital status and GBC was verified and the predicted nomogram was constructed.
Results: A cohort of 76 patients from Hangzhou Traditional Chinese Medicine (TCM) Hospital was selected as the external validation group, with an additional 3193 GBC patients obtained from the SEER database. Following PSM, both cohorts exhibited comparable 5-year cancer-specific survival rates. Notably, the results of the competing risk analysis unveiled a significant disparity in the 5-year cumulative incidence of cancer-specific death (CSD) between the two cohorts (59.1% vs. 65.2%, p = 0.003). Furthermore, the multivariate competing hazards regression analysis identified a noteworthy association (HR, 1.17; 95% CI, 1.04-1.31; p = 0.007) between marital status and CSD. To assess the 1-, 3-, and 5-year risks of CSD, a comprehensive competing event nomogram was constructed utilizing factors derived from the multivariate analysis.
The area under the receiver operating characteristic curve (AUC) values for the 1-, 3-, and 5-year training cohorts were 0.806, 0.785, and 0.776, respectively. In the internal validation cohort, these values were 0.798, 0.790, and 0.790, while the external validation cohort exhibited AUC values of 0.748, 0.835, and 0.883 for the corresponding time intervals.
Furthermore, calibration curves manifested a commendable level of concordance between the observed and predicted probabilities of CSD.
Conclusion: Marital status offers potential benefits for GBC. Married GBC patients have better cancer-specific survival. The suggested nomogram demonstrates exceptional predictive power.
Predictors of Mortality in Critically Ill Patients with Blood-stream Infections Caused by Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae
Authors: Teo Mei-Yuan , Leu Shaw-Wei , Chiu Li-Chung , Chang Ko-Wei , Wu Bing-Chen , Chuang Li-Pang , Lin Shih-Wei , Hsieh Meng-Jer , Wu Huang-Pin , Kao Kuo-Chin , Hu Han-Chung
Published: February 2024

Background
Infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae (KPC-Kp), particularly blood-stream infections (BSIs), are increasingly emerging as contributors to mortality in intensive care unit (ICU) patients. The challenge in treating KPC-Kp induced BSIs lies in the difficulty of providing early active antibiotic therapy and limited number of effective antibiotics available. The aim of this study was to identify predictive factors for mortality in critically ill ICU patients with KPC-Kp induced BSIs.
Materials and Methods
This retrospective study included the data of adult patients who had KPC-Kp induced BSIs and were admitted to the ICU of Chang Gung Memorial Hospital, Taoyuan, Taiwan, during the period from January 2017 to December 2021. All patients experienced respiratory failure and were on mechanical ventilation. We analyzed the outcomes in the patients with KPC-Kp induced BSIs.
Results
We included 168 patients with KPC-Kp BSIs during the study period. The 30-day mortality rate was 61.9%. Compared with the patients who survived, those who died had a higher Pitt bacteremia score (7.0 ± 2.6 vs 4.2 ± 2.9, P < 0.001), higher sequential organ failure assessment (SOFA) score (12.0 ± 4.1 vs6.2 ± 3.8, p < 0.001), a greater need for continuous renal replacement therapy (27.9% vs 9.4%, P < 0.002), and a higher prevalence of intra-abdominal infections (9.6% vs 0%, P < 0.001). In addition, patients who died within 30 days had lower platelets counts (93.7 ± 84.7 vs 171.1 ± 120.2, P < 0.001) and higher C-reactive protein (CRP) levels (131.3 ± 92.3 vs 88.7 ± 81.0, P < 0.003). Our multivariate analysis revealed that CRP levels and SOFA scores were independently associated with mortality, whereas treatment with a Ceftazidime-Avibactam based regimen and appropriate antibiotic treatment within 48 hours after BSIs onset were independently associated with favorable outcome.
Conclusions
Appropriate antibiotic treatments within 48 hours after BSIs onset and Ceftazidime-Avibactam treatment are crucial for reducing mortality among critically ill ICU patients.
Improving the End to End Protection in E-voting using BVM - Blockchain based e-Voting Mechanism
Authors: Gupta Sweta , Gupta Kamlesh Kumar , Shukla Piyush Kumar
Published: February 2024

The voting is always a crucial topic of public attention for democratic reasons. Due to its simplicity, ease of use, and low cost, e-voting is frequently used for such decision outcomes. The tremendous authority and intervening data in current e-voting systems, however, make them risky and make it difficult to achieve correct equity and clarity in e-voting. By combining e-voting with blockchain technology, these issues are resolved while providing reorganisation and intervention-resistant characteristics. A voter's improper manipulation, such as absenteeism, frequent voting, or non-party voting, may also undermine fairness. A verifier is therefore required to check the e-voting mechanism in order to ensure its effectiveness and control the process equality and fairness. In this paper, a Blockchain based e-Voting Mechanism (BVM) is developed for providing the end to end security and fairness for the transparent voting. This mechanism also provides a Zero-knowledge Proof (ZP) based verifier to inspect the voting procedure against voter`s misoperations and uses a Master-key Administration (MA) based public key cryptography to attack prevention. The utilization of blockchain technology ensures transparency, tamper resistance, and a high level of data integrity, making it a promising choice for modernizing and enhancing the electoral process. Also the performance of BVM has been compared and analysed based on time complexity, security analysis, performance factors like delay and throughput and antiattack examination.
Transport of American bullfrogs in plastic boxes with and without moistened foam: plasma biochemistry and erythrogram responses
Authors: Alves Adriana Xavier , Santos Nayara Netto dos , Reis Gean Paulo Andrade , Lana Mariele , Santos Bruno Dias dos , Azevedo Ragli Oliveira , Paulino Renan Rosa , Costa Frederico Augusto Alcântara , Campelo Daniel Abreu Vasconcelos , Veras Galileu Crovatto
Published: February 2024

This study aimed to evaluate two transportation methods on the plasma biochemistry and erythrogram responses bullfrogs. The animals were transported for 10 hours in boxes without and with moistened foam. Then, the frogs' condition was evaluated 0, 6, 12, 24, and 48 hours after transportation. There was no mortality. The glucose in frogs, in both transportations, increased at 0 and 12 hours and returned to basal levels at 24 hours. Triglyceride increased in animals 0 and at 6 hours, in both transportations. After 12 hours, frogs transported with foam recovered, while the without foam recovered after 24 hours. Plasma proteins and globulins increased in frogs at 0 hours, under both transportations. After 48 hours, there was a reduction in plasma proteins in frogs transported without foam. Globulins decreased 24 hours in frogs transported without foam and after 48 hours under both transportations. Albumin increased in animals at 12, 24, and 48 hours. Frogs transported with foam had high albumin. The albumin/globulin ratio increased in frogs evaluated 24 and 48 hours, in both transportations. The number of erythrocytes was higher in frogs evaluated 0 hours, in both transportations, and recovered 6 and 12 hours in transported with and without foam, respectively. Hematocrit and hemoglobin were higher in frogs evaluated 0 hours and recovered after 6 hours, in both transportations. MCV increased in frogs transported with foam 48 hours after transportation. MCH decreased in frogs evaluated 12, 24, and 48 hours, in both transportations. In bullfrogs transported with foam, MCHC was lower.
Predictive model of prognosis index for invasive micropapillary carcinoma of the breast based on machine learning: A SEER population-based study
Authors: Jing Zirong , Yu Yushuai , Yu Xin , Wang Qing , Huang Kaiyan , Song Chuangui
Published: February 2024

Background
Invasive micropapillary carcinoma (IMPC) is a rare subtype of breast cancer. Its epidemiological features, treatment principles, and prognostic factors remain controversial.
Objective
This study aimed to develop an improved machine learning-based model to predict the prognosis of patients with invasive micropapillary carcinoma.
Methods
A total of 1123 patients diagnosed with IMPC after surgery between 1998 and 2019 were identified from the Surveillance, Epidemiology, and End Results (SEER) database for survival analysis. Univariate and multivariate analyses were performed to explore independent prognostic factors for the overall and disease-specific survival of patients with IMPC. Five machine learning algorithms were developed to predict the 5-year survival of these patients.
Results
Cox regression analysis indicated that patients aged > 65 years had a significantly worse prognosis than those younger in age, while unmarried patients had a better prognosis than married patients. Patients diagnosed between 2001 and 2005 had a significant risk reduction of mortality compared with other periods. The XGBoost model outperformed the other models with a precision of 0.818 and an area under the curve of 0.863. Important features established using the XGBoost model were the year of diagnosis, age, histological type, and primary site, representing the four most relevant variables for explaining the 5-year survival status.
Conclusions
A machine learning model for IMPC in patients with breast cancer was developed to estimate the 5-year OS. The XGBoost model had a promising performance and can help clinicians determine the early prognosis of patients with IMPC; therefore, the model can improve clinical outcomes by influencing management strategies and patient health care decisions.
Gasoline Vehicle Performance Evaluation Using Gasoline-Ethanol-Water Emulsion as a Fuel
Authors: Gzate Yewondwosen
Published: February 2024

The aim of this work is to improve and compare the performance of pure gasoline ethanol blend and hydrous ethanol blend fuels for spark ignition engine without major fuel system component modification. The comparative experiments were conduct on mechanical gasoline engine fueled with pure gosine, E10 and HE10.The effects of the engine loads and the additions of ethanol and water on combustion and emission characteristics were analyzed deeply. The modified engine was tested with gasoline-ethanol-water blend emulsion as a fuel, and the effect of data were recorded on brake torque, brake power, brake specific fuel consumption, thermal efficiency, exhaust emission (CO, CO2, HC, O2) and smoke emission. In addition to performance test, the study on the miscibility of water, ethanol and gasoline blend was conducted mainly to know what extent water can be added to ethanol gasoline blend without phase separation. The amount of water it can be tolerate in the hydrous alcohol when used as a blending component with gasoline is up to 5% of ethanol. Higher water solubility in ethanol gasoline blends may be obviously useful and suitable nevertheless, temperature continuous ability of water to remain soluble in the blend is significantly affected by temperature and improvement in combustion characteristics. According to the experimental results, compared with pure gasoline and E10 blend, HE10 showed higher peak brake torque at high load. Increases in brake power were observes for HE10 fuel at all the operating conditions. The usage of HE10 fuel at optimum load conditions reduces HC, CO and CO2 emissions significantly. In addition, decreases in NOX emissions were observed for HE10 from 0 Nm to 80 Nm. From the results, it can be concluded that HE10 fuel can be regard as a potential alternative fuel for gasoline engine applications.
Contamination of a drug consumption room with drugs and potential risks for social health care workers
Authors: Cuffaro Flore , Dahm Georges , Marson Claude , Berlemont Patrick , Yegles Michel , Allar Claudia , Fauchet Lionel , Creta Matteo , Schneider Serge
Published: February 2024

Background
Studies have shown that contamination of surfaces by illicit drugs frequently occurs in forensic laboratories when manipulating seized samples as well as in pharmacies and hospitals when preparing medicinal drugs. In this project, we extended these studies to a Drug Consumption Room to investigate drug levels and possible exposure of the staff members.
Methods
We investigated pre and post cleaning contamination by heroin and cocaine and their degradation products 6-monoacetylmorphine and benzoylecgonine on different surfaces (tables, counters, computers and door handles) and in the ambient air. We also collected urine and hair samples from staff members to check for potential short and long term contaminations.
Results
Medium to heavy contamination has been detected on most surfaces and door handles; as expected, air contamination was particularly high in the smoking room. Drug levels were <LOD to very low in the urine and the hair samples of staff members tested.
Conclusion
The cleaning efficiency of the surfaces, carried out by staff and drug users after drug consumption, was often not satisfactory. The very low drug levels in hair indicate that acute health risks for staff members are low.
Deadlock-free, Safe, and Decentralized Multi-Robot Navigation in Social Mini-Games via Discrete-Time Control Barrier Functions
Authors: Chandra Rohan , Zinage Vrushabh , Bakolas Efstathios , Stone Peter , Biswas Joydeep
Published: February 2024

We present an approach to ensure safe and deadlock-free navigation for decentralized multi-robot systems operating in constrained environments, including doorways and intersections. Although many solutions have been proposed that ensure safety and resolve deadlocks, optimally preventing deadlocks in a minimally invasive and decentralized fashion remains an open problem. We first formalize the objective as a non-cooperative, non-communicative, partially observable multi-robot navigation problem in constrained spaces with multiple conflicting agents, which we term as social mini-games. Formally, we solve a discrete-time optimal receding horizon control problem leveraging control barrier functions for safe long-horizon planning. Our approach to ensuring liveness rests on the insight that there exists barrier certificates that allow each robot to preemptively perturb their state in a minimally-invasive fashion onto liveness sets i.e. states where robots are deadlock-free. We evaluate our approach in simulation as well on physical robots using F1/10 robots, a Clearpath Jackal, as well as a Boston Dynamics Spot in a doorway, hallway, and corridor intersection scenario. Compared to both fully decentralized and centralized approaches with and without deadlock resolution capabilities, we demonstrate that our approach results in safer, more efficient, and smoother navigation, based on a comprehensive set of metrics including success rate, collision rate, stop time, change in velocity, path deviation, time-to-goal, and flow rate.
Vertically probabilistic selling mechanism under asymmetric quality-tier competition: An analytical
exploration
Authors: Yang Guang , TIAN Lin
Published: February 2024

Compared with the existing literature that focuses on horizontal features of probabilistic selling (PS), PS in vertical quality markets is receiving significant attention in the travel and marketing industries, both in the United States and China. Focusing on a general framework for a vertically PS mechanism that involves firm asymmetric quality-tier competition and the active role of an intermediary retailer, we consider a duopoly, where the leader firm can endogenously generate differentiated quality PS products via either the direct channel or the indirect channel through an intermediary retailer, while the follower firm sells transparent products by providing exogenously differentiated quality levels. Utilizing Stackelberg game theory, we construct an economic model involving PS under asymmetric competition by quantifying probabilistic products in terms of expected quality and provide firms with profit-maximizing strategies under three scenarios. Second, we theoretically analyze three strategies to identify the advantages of PS, and further conduct a comparison of PS and traditional selling (TS) in terms of revenue pricing, social welfare and consumer surplus.Our results suggest that (i.) PS is not always profitable; only if the expected quality level is low could PS be effective; (ii.) PS could weaken asymmetric quality-tier competition and further mitigate cannibalization effect. In our duopoly model, if there were no probabilistic sales, the equilibrium would eventually converge to a situation where one Firm produces a high-quality product and the other produces a relatively low-quality product. Finally, we extend our model by incorporating attitude to risk and word-of-mouth persuasion. These additions enhance the applicability of our conclusions.
Pengembangan Mobile Learning KORS pada Materi Fungsi Komposisi dan Invers untuk Melatih Kemampuan Berpikir Kritis
Authors: Siregar Alfi Syahrin , Listiawan Tomi
Published: February 2024

Technology that continues to develop requires teachers to continue to innovate in presenting quality learning media. Mobile learning is a medium that can be used in learning because of the ease in the process of using it anywhere and anytime. On the other hand, critical thinking is a very important ability in mathematics. Through critical thinking skills, students are required to be able to generate thoughts and choose the right steps to solve a problem. However, the results of the field study show that students' critical thinking skills in material on compositional and inverse functions are still very low. This study aims to develop mobile learning named KORS to train students' critical thinking skills in the matter of compositional and inverse functions. This type of research is development research with the ADDIE model. The subjects of this study were practitioners and six high school students. In collecting data, assessment instruments were used by media experts and material experts, as well as student and teacher response questionnaires. The results of this study obtained KORS mobile learning media that were feasible to use with a percentage of 79% from media experts and 78.67% from material experts. The practicality of the media from the teacher's assessment obtained a percentage of 83.33% and based on the results of small-scale trials obtained a student response questionnaire percentage of 82.67%.
Conceptual Understanding of Students with Special Needs in Two-dimensional Shapes Based on Pirie Kieren's Theory
Authors: Jannah Ukhti Raudhatul , Hafsi Ainur Rofiq , Nurhidayati Septia
Published: February 2024

This study aims to describe the conceptual understanding of two-dimensional shapes in students with special needs based on Pirie Kieren's theory  in terms of learning motivation. This research is a case study with the research subject is 1 students with special needs of class IV at SDN Pademawu Timur V The results of this study are low learning motivation with layers of understanding on the square starting from Image making then head to property noticing to ineffective folding back to image making and do ineffective folding back again to primitive knowing. In solving the square problem, the subject doubled back to ineffective image-making and primitive knowing. Meanwhile, in the rectangular problem, the subject does one folding back to image making. There are similarities in solving square and rectangular problems, for example, the subject describes the two-dimensional shape first before image making and folding back because they don't know how to calculate the area of a square and rectangle. From the similarities and differences in the thinking flow of students with special needs in squares and rectangles, educators are expected to be able to pay attention to their understanding abilities and learning motivation before carrying out learning.
Pengembangan LKPD dengan Pendekatan STEAM melalui Model PjBL untuk Menumbuhkan Keterampilan Berpikir Kreatif pada Materi Lingkaran Kelas VIII
Authors: Wening Tyas Candra , Hayuhantika Diesty
Published: February 2024

Creative thinking is an important skill that includes aspects of flexibility, fluency, originality and elaboration. One of the problems encountered in the field is the low creative thinking skills of students. One of the teaching materials that can help teachers overcome this problem is the innovative Student Worksheet (LKPD) with a STEAM approach through the PjBL model in circle material which has relevance to creative thinking skills. This research aims to describe the process and results of developing LKPD using the STEAM approach through the PjBL model to foster creative thinking skills in valid class VIII circle material. This research uses a research and development (R&D) approach referring to the Holistic 4D development model which is adapted to only include the define, design and develop stages. The research results show that the feasibility percentage based on the media expert's assessment is 80% and the feasibility percentage based on the material expert's assessment is 86.8%. Meanwhile, the eligibility percentage based on the results of the practitioner questionnaire was 86.7% and the eligibility percentage obtained based on the results of the user questionnaire was 86.9%. Thus, the product developed is suitable for use as teaching material that fosters students' creative thinking skills.
Pengembangan Media Pembelajaran Berbantuan Lectora Inspire dan Plotagon pada Materi SPLDV untuk Meningkatkan Kemampuan Berpikir Kritis Siswa
Authors: Setiawan Muhamad Nur , Fatahillah Arif , Adawiyah Robiatul
Published: February 2024

This research aims to describe the process and results of the development of learning media with 3D characters assisted by Lectora Inspire and Plotagon software to improve student's critical thinking skills in the material of systems for solving systems of linear equations in two variables. This research uses research and development methods with a 4D development model. This development model consists of four stages, namely definition, design stage, development stage, and dissemination stage. The learning media developed must meet the feasibility requirements, namely valid, practical, and effective. The results of this research show that the average validity value of the 3 validators is 90% and is included in the valid category. The level of practicality of learning media is 92% based on user questionnaire responsses and is included in the practical category. The level of effectiveness is determined based on the N-Gain results of 28 students who took the pretest and posttest with a percentage result of 79% so it is in the effective category. Based on these results, the learning media developed was proven to be valid, practical, and effective in improving students' critical thinking skills.
Profil Pengajaran Guru Matematika terhadap Kemampuan Pengelolaan Kelas Berbasis Rencana Kegiatan Belajar Mengajar (RKBM) pada Materi Pertidaksamaan Rasional
Authors: Mukminin M. Nashihul , Amelia Riska Putri , Haq Rafli Fayzul , Rofiki Imam
Published: February 2024

Good classroom management is very necessary for teachers to achieve learning objectives. However, previous research states that classroom management in the implementation of mathematics learning on rational inequality material is still less than optimal. This is caused by the lack of the teacher's ability to manage the class. As a result, students are less interested in participating in learning activities. Therefore, this study aims to describe the teaching profile of mathematics teachers on classroom management skills on rational inequality material based on the Teaching and Learning Activity Plan (RKBM). This research uses descriptive research with a qualitative approach. The participants of this study were a mathematics teacher of MAN 2 Malang City and 36 students of S1 IPS-1 (Grade 10). Data collection techniques were observation, interview, and documentation. Data analysis techniques were carried out in several stages, namely data collection, data condensation, data presentation, and conclusion drawing. The results showed that RKBM-based mathematics teacher teaching could support good classroom management including, the majority of students being enthusiastic in participating in learning activities and students orderly carrying out the instructions given by the teacher. The results of this study can be used as a reference for teachers to design creative and interactive learning activities
Some features of thermohaline processes in the coastal zone of Arctic seas
Authors: Lukyanov S. V. , Karsakov A. L. , Averkiev A. S. , Tatarenko Yu. A. , Smirnov Yu. Yu.
Published: February 2024

The thermohaline processes in the Arctic coastal zone of seas in  Russia are analyzed on the example of some parts of the Barents and Kara Seas: specifically, the Medynsko-Varandey site and the near-mouth coast of the Ob and Yenisey. For comparison with the thermohaline characteristics of international waters, the authors used observation data obtained by  Admiral Vladimirsky oceanographic research ship in the summer  — autumn of 2014 and Professor Multanovsky in the summer — autumn of 2019 (“Transarctica 2019”). The study aims to obtain typical and extreme distributions of hydrological characteristics in order to estimate heat and salt fluxes in the bottom layers. The characteristic substance fluxes can be used in the calculations of fluxes in bottom sediments, which have a significant effect on permafrost thawing. Such sedimentary rocks constitute a new source of minerals in the Arctic zone. In order to calculate heat and salt fluxes, it is necessary to obtain high spatial resolution data. The available data may be insufficient, thus requiring integrated oceanological observations in the coastal zone.
Changes in climatic conditions in the Gulf of Ob region
Authors: Akselevich V. I. , Mazurov G. I.
Published: February 2024

The article describes weather conditions characteristic of the quasi-homogeneous climatic region of the Gulf of Ob, lists the main oil and gas condensate, gas condensate, and gas fields, as well as specifying the main requirements for the organization of a full-scale monitoring of weather conditions in the selected region. Climate changes were analyzed using reports on the weather conditions of different regions of the Russian Federation in 2017–2021, prepared by the All-Russian Research Institute of Hydrometeorological Information–World Data Centre. The data analysis revealed primarily positive deviations of the mean monthly temperature from the norm. A positive temperature anomaly was observed in 83% of cases. The climate in the Gulf of Ob region has been getting drier and colder in winter these past five years, which complicates winter navigation. Over the past five years, drier weather has been observed in 50% of cases.
Análise tridimensional das rugosidades palatinas como ferramenta de identificação biométrica
Authors: Araújo Monique Miranda , De Oliveira Xaiane , De Freitas Ricardo Almeida Caribé , Marques Jeidson Antônio Morais , Musse Jamilly de Oliveira
Published: February 2024

As rugas palatinas são formadas por um tecido conjuntivo, esse tecido tem a função de recobrir o processo palatino, e está localizada no osso da maxila. Por ter uma anatomia imutável e única em cada indivíduo, o método de identificação humana por meio das rugas palatinas tem muito potencial para se tornar incontestável. Atualmente, com a incorporação de novas tecnologias na odontologia, a análise das rugas palatinas de forma tridimensional a partir do escaneamento se tornou uma realidade. O presente trabalho teve como objetivo analisar a aplicabilidade da análise tridimensional das rugosidades palatinas para identificação humana, através da observação de imagens em 3D, resultantes do escaneamento digital. Trata-se de um estudo experimental de abordagem quali-quantitativa, cuja amostra foi composta pelo escaneamento de 50 modelos de gesso, onde foram geradas imagens tridimensionais, as classificações utilizadas foram com as técnicas de Silva (1938), Carrea, (1937) e Bassauri (1961). O escaneamento 3D foi feito por um sistema de software da empresa Zirkonzahn, utilizando o scanner s600 arti e a análise das rugas foram realizadas pelo programa Meshmixer. As técnicas quando utilizadas separadamente não foram suficientes para realizar a identificação humana individual. Já o código individual gerado pela associação dos três métodos mostrou-se único para cada modelo utilizado. Desta forma, os resultados obtidos comprovaram a aplicabilidade da análise tridimensional das rugas palatinas para identificação humana.
Similar yet Different: A Comparative Study of Profitability Performance of Indian Retail Sector with a Special Reference to Big Bazaar and D Mart
Authors: Mistry Dharmendra S. , Vyas Pallavi C.
Published: February 2024

Indian retail market has developed by means of one of the fastest-growing markets due to economic growth and the access of more than a few new players. Rising revenue as well as demand for quality products increases consumption expenditure. The existing research work goals to analyse the performance of the Indian retail segment and the aspects that make the Profit of Big Bazaar and D Mart, Different, despite their similar Sales revenue. Some variables such as Net Profit Margin, Inventory, Inventory turnover ratio, accounts receivables and Trade payables have been taken to study the profitability of the two selected players. It has been divulged that notwithstanding the insignificant variance in sales of Big Bazaar and D Mart, there has been a significant variance in Net Profit Margin, Inventory, Inventory Turnover ratio, Accounts Receivables and Trade Payables thereof. Though the sales of Big Bazaar and D Mart are marginally different, D Mart’s position and profitability performance have comparatively been seen healthier.
An Analytical study of Financial Ratios and their effect in EPS on Cement Companies in India
Authors: Sengupta Ashok , Singh Gajraj
Published: February 2024

The cement industry has a massive contribution to India’s GDP and infrastructure development. Due to the demand of cement, new companies from outside also started functioning in our country, but these industries face several problems. Companies are closed or merged due to a lack of financial sustainability and capital structure problems. The study is based on the effect of capital structure on shareholder’s value. In this study as a researcher, it has been tried to study and find out the relation of ROA, ROE, leverage ratios, and correlation with EPS. The sample size is five companies from the BSE list (Bombay Stock Exchange), and the last five years of data are studied. As the cement industry is capital-centric, this study will help the industry understand the facts that fulfill the financial objectives.
Role of Performance Management in Managing Talent Management Challenges during COVID-19 Pandemic and Beyond: A Conceptual Review
Authors: Singh Akanchha , Ahmad Ehtesham
Published: February 2024

Significant talent management challenges have come from the COVID-19 pandemic, like (a) temporary halt for non-essential recruitment and layoff to cut cost (b) wage-freezes, wage reduction 8 bonus cancellations (c) changed mode of working i.e., teleworking (d) increased work stress etc. Furthermore, COVID-19 has revealed that many organizations do not use state-of-science performance management systems rather, they have relied on the traditional system of a performance management system which includes occasional evaluation and less effort in the alignment of employees, individual goals, and organizational goals. As a result of the lack of value provided by the traditional performance management system, many businesses are fully eliminating performance reviews. We assert that performance management meets significant managerial, strategic developmental, and organizational maintenance if executed using evidence-based recommendations and thus can solve contemporary talent management difficulties. In this paper, an attempt has been made to give some suggestions on how to accept and strengthen the performance management system to help organizations face unprecedented situations like the COVID-19 pandemic. The present study is review of many articles, research papers, books, blogs etc. The current study is based on secondary data.
Sustainability in the Media Sector: A Case of DB Corp Ltd
Authors: Jee Kishan , Kumar Alok
Published: February 2024

Today’s sustainability definition for any organization worldwide incorporates an innovation parameter supported by human endeavors. The onus of mutual growth of individuals (the entrepreneur or the worker) and the organization lies in the perception about the human factor and its optimal utilization with a sense of social responsibility. Businesses get affected by the macro-environment, but it gets acclimatized quickly only due to human endeavors towards sustainability. The present case highlights a business group from the media industry in India – the Dainik Bhaskar Group – under the corporate banner of DB Corp Ltd., which is not only one of the largest players in the media segment but also is popular for a plethora of innovative practices to excel and survive in the market place. The Group is known for its aggressiveness – be it the journalistic commandments or marketing practices or even the societal connect, perhaps that has made it sustain year-on-year with a much-needed consolidation of the financial base without losing the ‘customer focus’. The group has expanded towards cross-media ownership and is also present in other industrial segments. Overall, the different verticals synergize to give a tall figure to the group in their segment, which can proactively sense the opportunities through its business radar. The case presents a basket comprising of its different products, the industry scenario, the media and marketing innovations it has undertaken over the years, the strategic financial decisions it has taken towards further consolidation and a four-year Annual Report Analysis to test its financial viability/sustainability in the competitive market space. It is now for the group to decide how to reinvent itself in managing the unrepresented areas.
Scope of Social Innovation in Tribal Development
Authors: Dos Ghanshyam , Naqvi Doa
Published: February 2024

The aim of this article is to study the various field of tribal areas where social entrepreneurs are working. the first introduction, includes social innovation and tribal peoples, the second review of literature includes a small summarization of literature on social innovation in the field of tribal development, the third research methodology, this article is based on secondary data and also includes some research questions which are covered in it, fourth analysis and finding section, we found over 20 enterprises in the various field for tribal development i.e. health, agro informatics, agriculture, financial inclusion, etc. fifth discussion and conclusion.
The Effect of Celebrity Endorsement on Consumer Buying Behaviour: A Comparative Study between Female & Male consumers
Authors: Sharma Sonam , Kumar Pradeep
Published: February 2024

In India, the practice of celebrity endorsement is experiencing a tremendous surge, similar to that observed in other industrialised and developing nations. This article aims to analyse the impact of celebrity endorsement on the purchase intention of male and female customers in the mobile phone industry. An empirical study was conducted to investigate the variables that influence customers’ intention to make a purchase. The study utilised a sample of 200 individuals, consisting of 100 males and 100 females. This research employed a questionnaire technique, with both male and female respondents being administered the same questionnaire. An analysis involving descriptive statistics and regression was conducted to obtain the findings. The study identified likeability, attractiveness, experience, and personality as the primary factors that significantly affect male buyers’ inclination to acquire mobile phones through celebrity endorsements. Female shoppers consider the likeability, beauty, and believability of the celebrity while buying a mobile phone. This study primarily examined the intention of consumers to purchase mobile phones and the impact of celebrity endorsement. It is recommended that a researcher should carry out a comparative study between males and females for another product category, using a substantial sample size. The study presents strategies for using celebrity endorsement to enhance male and female customers’ inclination to purchase mobile phones. To develop an advertising policy that targets male or female clients, marketing managers or policy makers might adhere to the following guidelines.
Collaborative Security in Wireless Networks and Vulnerabilities Assessment for Fintech E-payment Companies: A Bibliometric Analysis
Authors: Verma Aanchal N.
Published: February 2024

The purpose behind the technical analysis and science mapping in front of researchers to make them aware of the Internet of Things and mobile networking for providing collaborated security along with a visualized presentation to the financial and engineering researchers about the virtual vulnerability assessment issues. The objectives of this study are to analyze the available review of the literature and measure the most cited Journals through citation analysis and co-authorship analysis. The approach of BA (Bibliometric Analysis) has been executed in order to visualize literature reviews systematically. The researcher performed an in-depth study with reference to Collaborative Security and wireless networks (582), Collaborative Security and vulnerability assessment (253) and WiFi Security and Vulnerability Assessment (34) studies are available. The figures have been made through executing data over VOSviewer and tables are formed after compiling various affiliations. This technical study will help provide a literature base for more research to be executed in the arena of Information Systems (IS), Engineering, Computer Sciences, and Financial Technology. Also, it will provide a conceptual record for those practitioners and policymakers who are interested in performing exploratory research on wifi security assessment. It has been observed that more work can be done quantitatively for having certain measures regarding the virtual aspects of collaborative security amid its issues related to payment systems. Just mentioned the data are from Google Scholar and Dimensions.
Diagnosing the HR Practices within a B-School System in India
Authors: Kumar Alok
Published: February 2024

There was a phase in the early to mid-nineties of the ‘mushrooming’ of stand-alone B-Schools, that could be called as first generation B-schools owing to their incarnation as an institution deliberately manufactured to manufacture the input materials for the ‘about to be scaled up’ Corporate sector considering the Liberalization policy of the then existing Government. Three decades following this, another round of mushrooming is being witnessed again, but this time a more broad sensed University system aimed at offering a relatively bigger basket of more technical courses under the colossal propagation of the New Education policy of the Government. Universities are crossing the 1100 mark now in India, thereby, resulting in a rapid surge in demand of different kind of human resources to cope up with the speedy trajectory desired for positioning the Institution under the leader category! This article tries to find out whether approaches towards the fulfillment of HR acquisition objectives have a conducive directional flow or an erratic one, and also how the demandsupply is being managed! It tries to suggest effective ways in which requisite manpower for B-Schools can be had keeping in mind the emerging academic and industrial environment not only in India but across the Globe!