bluuebunny/crossref_metadata_2025 huggingface dataset:
Increasing Feasibility with Dynamic Priority Assignment in Distributed Trajectory Planning for Road Vehicles
Authors: Scheffe Patrick , Dorndorf Georg , Alrifaee Bassam
Published: May 2022

Nonconvex optimal control problems for large-scale networked control systems (NCSs) can be distributed to accelerate computation time. One distribution strategy is priority-based non-cooperative distributed model predictive control. The priorities assigned to agents determine if a feasible solution for all agents exists. This problem has been investigated in the domain of robotics for many years, and has recently been picked up in the domain of road vehicles. We develop a dynamic priority assignment algorithm for road vehicles based on an approach from the domain of robotics. In our algorithm, each vehicle determines its priority in a distributed fashion. The priority of a vehicle increases with the number of potential collisions on its planned path to increase the success of the distributed control problem. We further propose an approach for priority-based non-cooperative distributed model predictive control with dynamic priorities and prove recursive feasibility for the NCS. This paper presents the first evaluation in experiment of the priority assignment algorithm. We compare the algorithm’s performance to dynamic random priorities and to static priorities.
Educación para la ciudadanía global en las universidades. Retos y oportunidades
Authors: Sanabria Fernandes Stefany M. , Longueira Matos Silvana
Published: May 2022

La Educación para la Ciudadanía Global (ECG) se ha constituido como una herramienta educativa y social que favorece la construcción de una ciudadanía comprometida con los grandes retos globales, desde una visión y acción local y global. Esta ha sido impulsada desde el ámbito de intervención de la Cooperación Internacional para el Desarrollo, promoviendo desde ahí, la inserción de esta herramienta en los distintos procesos educativos formales, no formales e informales. La incorporación de los contenidos de la ECG en los distintos contextos educativos, ha adquirido una gran dimensión debido al abordaje educativo de los desafíos globales que plantea la Agenda 2030. En este marco, las universidades han integrado parte de este desarrollo en sus dimensiones: formación, investigación, gestión y extensión universitaria. Por lo tanto, en este trabajo se pretende, a través de la revisión de la literatura existente sobre esta temática, elaborar un corpus teórico que haga patente el nexo entre la ECG y su incorporación la formación universitaria, como parte del ejercicio de la Cooperación Universitaria al Desarrollo (CUD) y la Responsabilidad Social Universitaria (RSU).
Sub-Acute Sclerosing Panencephalitis Manifesting as Psychiatric Illness: A Case Report
Authors: Kaur Dr. Gurmeet , Goyal Dr. Priyanka , Dr. Richa Dr. Richa , Chaudhry Dr. Manika
Published: May 2022

Subacute sclerosing panencephalitis (SSPE) is a chronic progressive inflammatory central nervous system disorder manifesting as a rare complication of measles viral infection in childhood resulting in fatality in all cases. It is likely to have possibility of subclinical or undiagnosed measles in early childhood in absence of prior overt measles infection. Measles vaccine has a protective effect against SSPE and high vaccination gap is associated with higher incidence of SSPE. Children residing in areas with poor vaccination coverage are at increased risk of developing the disease. It is characterised by progressive intellectual deterioration, seizures, myoclonus, ataxia and visual disturbances. The onset of SSPE is insidious and can manifest as significant psychiatric ailments. A 17 years old girl with history of progressive scholastic deterioration for a year presented with focal seizures, myoclonic jerks and psychiatric manifestations like emotional outburst followed by progressive unresponsiveness, altered sensorium and memory lapses since two weeks. A diagnosis of Subacute sclerosing panencephalitis (SSPE) was made on the basis of clinical symptoms, typical EEG changes and presence of anti-measles antibody in cerebrospinal fluid. Patient received treatment for myoclonic jerks, spasticity along with supportive care. SSPE is often a chronic inflammatory and life threatening disease of central nervous system with no cure despite development of antiviral and immunomodulator drugs. There is urgent need to advocate policies to enhance vaccination coverage and for extensive research in field for potential therapies for treatment of such patients to improve clinical outcomes.
Nederlandse walvisvaarders op Nova Zembla
Authors: Maticsák Sándor , Pusztai Gábor
Published: May 2022

The Russian Orenburg expedition made important discoveries in Russia’s inlands between 1768 and 1774. One of the members of the expedition Nikolai Ozereckowsky (1750–1827), who was only eighteen years old at the time, gave a description of Nova Zembla. In 1788, information of local fishermen was added by Ozereckowsky to this description, of which one was a short passage about Dutch sailors. In our article we would like to shed light on, besides the original text, the background of the Orenburg expedition and Dutch whaling.
REALISASI PENDAPATAN ASLI DAERAH DI SEKTOR PARIWISATA KABUPATENTULUNGAGUNG
Authors: Ananada Galuh Puspita  , Cindy Claudia Radha Avita
Published: May 2022

AbstractThis study aims to find out how the income realization in the tourism sector in Tulungagung Regency. The diversity of tourism objects in Tulungagung has become an asset or source of local revenue. Another advantage obtained is the creation of jobs in the community and an increase in the tourism industry. This study uses a qualitative method. Where the data used is sourced from secondary data in the form of journals, articles and books. Qualitative research methods are used to examine the problem. The information collection technique used is groundwork information abstraction in the form of secondary information. In this study, the tourism sector in Tulungagung Regency was studied through the use of media. The use of the media in question is the web. Documentation of research reports, and journals from around the world. The results of this study show that regional financial income comes from local taxes and levies, one of which is in the tourism sector. The Tulungagung Regency Government has a revenue target in the tourism sector, but it has not been met due to the COVID-19 pandemic. The income of the tourism sector is very influential on the Regional Original Income (PAD) of Tulungagung Regency.AbstrakPenelitian ini bertujuan mengetahui bagaimana realisasi pendapatan pada sektor pariwisata di Kabupaten Tulungagung. Keanekaragaman objek wisata di Tulungagung telah menjadi suatu asset atau sumber dari Pendapatan Asli Daerah . Keuntungan lain yang didapatkan yaitu terciptanya lapangan kerja di masyarakat serta peningkatan industri pariwisata. studi ini memakai metode kualitatif. Dimana data yang dipakai bersumber dari data sekunder yang berupa jurnal, artikel maupun buku. Metode penelitian kualitatif digunakan untuk meneliti masalah tersebut. Teknik pengumpulan informasi yang digunakan adalah abstraksi information groundwork yaitu berupa information sekunder. Dalam penelitian ini, sektor pariwisata di Kabupaten Tulungagung dikaji melalui pemanfaatan media. Pemanfaatan media yang dimaksud yaitu web. Dokumentasi laporan penelitian, dan jurnal dari seluruh dunia.Hasil penelitian ini diketahui bahwa pendapatan keuangan daerahberasal dari pajak serta retribusi daerah, salah satunya di bidang pariwisata. Pemerintah Kabupaten Tulungagung memiliki target pendapatan di sektor pariwisata, namun belum terpenuhi akibat pandemi COVID-19. Pendapatan sektor pariwisata sangat berpengaruh terhadap Pendapatan Asli Daerah (PAD) Kabupaten Tulungagung.
Leg Length Discrepancy
Authors: Berianto Agustian  , Tertianto Prabowo  , Dian Marta Sari
Published: May 2022

ABSTRACT

Leg length discrepancy (LLD) is a condition of length differences in the lower extremity, caused by variety of factors, both congenital and acquired. Measurement using measuring tape, block test, and supine-tositting test based on bony landmarks is considered less accurate than imaging techniques. Measuring LLD can be difficult in certain cases such as obesity, leg deformities, and post arthroplasty. Individuals will develop biomechanical strategies to compensate inequality of leg when standing, walking, andrunning on their feet, ankles, knees, hip, and or pelvis to minimize energy consumption. It can causes several complications, including osteoarthritis, functional scoliosis, intervertebral disc degeneration, stress fractures, cardiovascular and neuromuscular problems. Management varies from wearing a shoelift, relieve muscle and joint contracture, and surgical procedures. This paper was written to review measurement technique, biomechanical compensation strategies, complication, and management of LLD from Physical Medicine and Rehabilitation point of view .Keyword: biomechanical compensation strategies, leg length discrepancy, lower extremity, management, measurement
Case Report of Speech and Ambulation Ability After Five Years Therapy in a Six-Year-Old Boy with Habilitation Sixth Lumbar Spina Bifida with Meningocele Post Resection and Hydrocephalus Post VP Shunt
Authors: Naela Munawaroh  , Lisa Nurhasanah  , Rahmi Isma AP
Published: May 2022

ABSTRACT

Introduction: Spina bifida, a congenital spinal cord injury, is a complex disability that results from a failure of the caudal neural tube to fuse early in embryonic development. Spina bifida affects about 300.000 newborns each year worldwide. Hydrocephalus is common in children with spina bifida, developing in 80% to 90% of children with myelomeningocele. Anatomical abnormalities in which the myelomeningocele sac occurs is associated with neurological, motor and sensory deficits. They showimpaired speech and ambulation.Case presentation: We report a six-year-old boy was taken to the hospital by his parents because he could not stand and walk since he was born. At birth there was a lump on the lower back, and the patient also had hydrocephalus, then surgery had been performed. The patient was diagnosed with sixth lumbar spina bifida and hydrocephalus with meningocele. He had some delay in gross motor, fine motor and language development. The patient had history of seizures. He received trunk control exercise, pelvic stabilityexercise, positioning and handling, coordination exercises and fine motor skills to increase independence in activities of daily life. The patient obtained 4 years exercises of speaking, comprehension, vocabulary and articulation. The child also received attention and concentration enhancement exercises.Conclusion: A patient with spina bifida requires a lifelong commitment by the patient, family, and the health care personnel involved in the treatment. The medical goal is to maintain stable neurological functioning throughout the patient’s lifetime. The wide range of extensive speech and ambulation impairments and long-term disabilities in patients with spina bifida present a considerable challenge to the management of these patients.Keywords: ambulation, hydrocephalus, meningocele, speech, spina bifida
EVALUASI PROGRAM BROADBAND LEARNING CENTER DINAS PERPUSTAKAAN DAN KEARSIPAN KOTA LUBUKLINGGAU
Authors: Asih Kurnia Sari Nur , Nopianti Heni , Sa'diyah Lailatus
Published: May 2022

The purpose of the study was to determine the implementation of programs related to the evaluation of the Program  Broadband Learning Center at the Lubuklinggau City Library and Archives Service. The research method is descriptive quantitative. The research sample totaled 93 (ninety three) respondents from participants who attended training in 2017, 2018, 2019, and the samples were taken randomly. The results of the component research input obtained a result of 4.09 (four point nine blanks) included in the Good criteria. The component Activities and Processes obtained a result of 3.84 (three point eighty four) included in the Good criteria, but there were 2 (two) statements in this component that obtained an average score with poor criteria.The component Output obtained a result of 4.10 (four point ten) which is included in the Good criteria. The results of the recapitulation of the components Input, Activities and processes, as well as the Output of 4.01 (four point blank one) are included in the Good criteria with the predicate successful.
PENGUATAN PERPUSTAKAAN PADA GERAKAN LITERASI SEKOLAH DI SMPN 18 PADANG
Authors: Ratnawita Ratnawita , Masyhudi Fauza , Nugraha Frasandy Rendy , Alfurqan Alfurqan
Published: May 2022

This study aims to explain the strengthening of the library in the school literacy movement at SMP Negeri 18 Padang. The research method used is a qualitative descriptive method with a single instrumental case study approach because the researcher collects detailed information collected using various data collection procedures over a continuous period of time, which explores in-depth information related to literacy at SMPN 18 Padang. The results showed that there were 2 (two) roles of libraries that were strengthened in the school literacy movement at SMP Negeri 18 Padang, namely the role of libraries as information providers and the role of libraries as managers of student reading materials which must be supported by adequate information technology.
TECHNOLOGY OF USING STARPAT IN THE PROFESSIONAL TRAINING OF PEDAGOGICAL UNIVERSITY STUDENTS
Authors:   Samara State University of Social Sciences and Education, Avetisyan V.R. , Grabozdin Yu.P. , Semenov A.A.
Published: May 2022

In the conditions of modernization and informatization of the educational system, many different approaches, technologies and practices appear in the pedagogical environment that contribute to improving the quality of modern education and reflect the needs of modern society. One of such innovative technologies is the technology of using a startup. This technology is aimed not only at developing financial literacy among students, but also contributes to the formation of many vital personal qualities in future specialists. Among them it should be noted: the development of creative abilities, critical thinking, skills of working with information sources. The startup in the educational environment has been used relatively recently. Startups are especially rarely used in pedagogical universities. However, recently they have increasingly attracted the attention of university management, teachers, students, as well as business. This article provides information reflecting the possibility of using the technology of startups with students of the pedagogical University, created using information and communication technologies. Student startups can be carried out by them as preparation of final qualifying works (diplomas, bachelor's works and master's theses).
THE ROLE OF FUNCTIONAL SYSTEMS IN THE PROCESS OF ADAPTATION TO PHYSICAL EXERTION
Authors:   Samara State Technical University, Krasilnikov A.N. , Turbina Е.G.
Published: May 2022

This article reveals such an important problem as human adaptation to physical activity and its impact on the functional state of the body. Adaptation is the basis of evolution, the result of which is genetically fixed and inherited. The adaptation process includes urgent and long-term processes. The mechanisms of these processes must be considered from the standpoint of G.K. Anokhin. In the process of sports activities, the increase in working capacity is ensured by activating the relaxation mechanism of urgent adaptation. The high intensity of energy exchange under conditions of extreme physical exertion causes a progressive increase in aundose and the accumulation of metabolic intermediates in the body of an athlete. It has been shown that under conditions of physical stress, a multiple increase in the content of the main stress hormones in the blood and urine is observed. In relation to the process of adaptation to physical loads, the functional approach received an original interpretation in our studies regarding the concept of the locomotor (motor) functional system (LFS), which combines as components most of the systems classified according to anatomical and functional characteristics: central nervous, autonomic, neuroendocrine, cardiovascular, respiratory, neuromuscular and others. As a result of our research, it was found that the effect of an explosive increase in working capacity is provided by increasing this working capacity, by activating the relaxation mechanism of urgent mobilization of protection, the essence of which is to activate the inhibitory systems of the central nervous system, normalize the process of relaxation of skeletal muscles and significantly increase its speed during the interaction of the body with various adaptogenic factors. It was also found that under conditions of physical stress, there is a multiple increase in the blood and urine of the main stress hormones.
DIGITAL EDUCATION AT THE PRESENT STAGE: DIFFICULTIES AND PROSPECTS
Authors:   Surgut State University, Muller О.Yu.
Published: May 2022

The main goal of the Concept of the State Information Policy of the Russian Federation is the development and improvement of the education system, as well as professional training of personnel that ensures a full life and effective human activity in the modern information society. This goal involves a fundamental change in the organization and essence of the processes of learning and human development. The process of transforming the content, methods and technologies, changing the requirements for learning and its results is the digitalization of education. The purpose of the study is to consider the essence of the concept of "digital education" and identify factors that allow us to present the advantages and disadvantages of digital education. Methods used in the study: literature review, empirical research, matrix analysis, comparative analysis. Empirical survey data were obtained, reflecting the main factors that make it possible to identify the positive and negative aspects of digital education during a pandemic. The article assesses the prospects for the development of digital education. A matrix of assessments of the existing experience of participation in digital education during the pandemic of teachers and students has been compiled. Based on the results of the analysis of the compiled matrix and the diagram that complements it, a conclusion is drawn about the insufficiently effective digital education at the current stage due to the presence of certain problems in the process of organizing online education. The digitalization of education during the crisis period has accelerated significantly, however, in the future, it will require the introduction of certain measures to integrate it with traditional education, while eliminating the shortcomings of both forms of education.
QUESTIONS AND PROSPECTS OF TEACHING THE TOPIC "SOLAR SYSTEM" IN THE TEXTBOOK "ASTRONOMY"
Authors:   Samara Engineering College, Plekhanov P.G.
Published: May 2022

The article deals with the issues of teaching the topic "Solar system" of the discipline "Astronomy". The old textbook "Astronomy" by E.P. Levina and new - B.A. Vorontsova–Velyaminova, E.K. Strout and V.M. Charugin - in which the material about the planetary system is borrowed from publications of the last century. At present, what is stated in the textbook by B.A. Vorontsova-Velyaminov and E.K. Strout, the historically established idea of the formation and structure of the solar system (from planets alone) contradicts new discoveries and the observed harmonious structure of the solar system. The erroneousness of assigning the status of "minor planet" to asteroids of the main belt and many objects of the Kuiper belt is substantiated. this leads students to the misconception that there are many planets in the solar system. To the textbook "Astronomy" V.M. Charugin, the author of this article prepared a textbook "The Solar System of the 21st Century", which provides a model of the structure of the entire Solar System and the cometary hypothesis of its origin. The textbook contains a table "Periodic system of celestial bodies of the entire solar system" for astronomy classrooms, similar in significance to the table "Periodic system of chemical elements of D.I. Mendeleev.
sinestesia en la música contemporánea
Authors: Rivera Fernández María Luz
Published: May 2022

En este trabajo presentamos la relación compleja entre el sonido y el color en la creación musical a lo largo de la historia que sigue siendo fructífera en la composición musical actual. La sinestesia en música establece una correspondencia entre sonido y color y ha sido un debate constante desde el siglo XVII. La naturaleza compleja del sonido aparece desde la antigua Grecia en la escuela de Pitágoras en la que el número se convierte en configurador de la armonía. Desde entonces surgen distintos intentos estéticos para relacionar el color y el sonido que llegan hasta los procedimientos electrónicos en nuestros días en la música contemporánea.
Relevance of Physiological Research in the European North of Russia Exemplified by Studies on the Photoperiodic Dynamics of Thyroid Profile Parameters
Authors:   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Zyabisheva Valentina N.
Published: May 2022

The plenary and breakout sessions of the multidisciplinary 4th All-Russian (19th) Scientific Youth Workshop Conference “Youth and Science in the North – 2022” provided a more detailed insight into particularly important issues of fundamental medicine and current physiological research conducted by young Russian scientists, including that in the European North of Russia. At the moment, the most relevant are studies on hypoxia and hypoxic training for athletes, as well as functioning of the cardiovascular system and consequences of COVID-19. Participating in the “Fundamental Sciences to Medicine” section, the author of this paper reported on one of the important topics of endocrine research in the European North of Russia, namely, photoperiodic dynamics of thyroid profile parameters, being key regulators of the body’s metabolic processes that play a significant role in its adaptation to changes in the environment.
Response of the Cardiovascular System to a Speed-Strength Exercise in a Cold Environment in Male Adolescents at the Age Stages of 14–15 and 15–16 Years
Authors:   N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences, Zaborskiy Oleg S. , Poskotinova Liliya V.
Published: May 2022

The purpose of this study was to determine the reactivity of the cardiovascular system after a speed-strength exercise in cold conditions using short-term biofeedback (BF) training to increase total heart rate variability (HRV) in adolescents aged 14–15 years and the following year, when they turned 15–16. Materials and methods. Healthy male adolescents were examined twice with an interval of 1 year (14–15 years old and 15–16 years old). Blood pressure (BP) and HRV were recorded before and immediately after a thrice-repeated standing long jump in the open air (t = –1…–10 °C) as well as during the recovery period. In the recovery period, the experimental group underwent BF training (3 min) using Varikard equipment (Ramena, Russia) to increase the total HRV power; the control group stayed at rest. Results. In adolescents aged 14–15 years after exercise in cold conditions total HRV and sympathetic activity remained stable (p > 0.05); during the recovery period, a pronounced decrease in systolic BP and preservation of vagal activity were detected in the BF group, in contrast to the control. Adolescents aged 15–16 after exercise had a more pronounced rise in sympathetic activity compared with those aged 14–15 years (p < 0.05); in the BF group, the decrease in total HRV power was less pronounced than in the control, with vagal activity preserved. Thus, in 15–16-year-old adolescents after a speed-strength exercise in the cold sympathetic activity and a decrease in total HRV were more pronounced than in those aged 14–15 years. During the recovery period, a short-term BF training (3 min) aimed to increase total HRV power contributes to preserving vagal activity in adolescents at both age stages.
Violencia hacia las mujeres: ¿es igual en todos los rangos de edad?
Authors: Castellano Arroyo María , Sánchez-Castellano Carmen
Published: May 2022

Analizamos la literatura más reciente sobre violencia de género, poniendo especialmente el foco en aquella que sufren las mujeres de más edad.  Más de una de cada cuatro mujeres en el mundo ha sufrido violencia de pareja a lo largo de su vida. Las mayores de 65 años son las más invisibilizadas y los recursos sociales y jurídicos muchas veces no dan una respuesta óptima para resolver su situación. Durante su juventud suelen sufrir violencia física, pero cuando envejecen predomina el maltrato psicológico y la negligencia o falta de cuidados, si los necesitan. Se sigue produciendo escalada de la violencia, muchas veces a través de conductas de control. El impacto acumulado ocasiona ansiedad y depresión, como en etapas anteriores de la vida, pero las mujeres mayores sienten pérdida de la resiliencia y de la capacidad para adaptarse a su situación, así como mayor vulnerabilidad. Desde los servicios sanitarios debemos ser capaces de detectar y encauzar las situaciones de violencia y desde los servicios sociales hay que buscar las intervenciones que puedan contribuir, en cada caso concreto, a apartar a las víctimas de la violencia que sufren y de sus consecuencias.
DEVELOPMENT THE THORACIC CAGE IN THE EARLY STAGES OF THE POSTNATAL PERIOD THE INFLUENCE OF ANTENATAL DIABETES
Authors:   Tashkent Pediatric Medical Institute, Uzbekistan, R.R. Turabekov , F.B. Juraeva ,   Tashkent Pediatric Medical Institute, Uzbekistan, L.I. Ibrokhimova ,   Tashkent Pediatric Medical Institute, Uzbekistan
Published: May 2022

The material of the study was 32 mature rats and their offspring. We used informative methods such as histological and histochemical, morphometric. As a result of the study, morphological changes in the bone-cartilaginous-ligamentous structure of the rib-sternal complex in the offspring obtained from pregnant rats with diabetes mellitus in the period of early ontogenesis are presented. It has been established that the negative impact of antenatal diabetes mellitus on the development of the connective tissue formation of the sterno-costal complex. This article describes the morphological changes in the anatomical structures of the rib-sternal complex in rat pups born from pregnant individuals with experimental diabetes mellitus.
CHARACTERISTICS OF ORGANIZATION OF PRIMARY SCHOOL MOTHER TONGUE LESSONS
Authors:   Student, Termez State University, Uzbekistan, Sharofjon Kizi Kamola Oltiboeva
Published: May 2022

This article is about the specifics of organizing elementary school native language classes. The role of mother tongue and literature in general secondary education is invaluable. The main goal of the science of mother tongue and literature is to develop a person who is logical and free-thinking, has a broad outlook, creative and artistic thinking. As our scholars say, "all the virtues of the world permeate the human heart, first of all, with the unique charm of the mother tongue." Therefore, the ideas of eternal love for the motherland, patriotism, humanity are realized, first of all, in the process of teaching students the native language. This is a testament to the responsibility of the mother tongue and literature teacher in the development of the younger generation.
Reductive opening of a cyclopropane ring in the Ni(II) coordination environment: a route to functionalized dehydroalanine and cysteine derivatives
Authors: Levitskiy Oleg A , Aglamazova Olga I , Grishin Yuri K , Magdesieva Tatiana V
Published: May 2022

Involvement of an α,α-cyclopropanated amino acid in the chiral Ni(II) coordination environment in the form of a Schiff-base is considered as a route to electrochemical broadening of the DA-cyclopropane concept in combination with chirality induction in the targeted products. A tendency to the reductive ring-opening and the follow-up reaction paths of thus formed radical-anions influenced by substituents in the cyclopropane ring are discussed. Optimization of the reaction conditions opens a route to the non-proteinogenic amino acid derivatives containing the α-β or β-γ double C=C bond in the side chain; the regioselectivity can be tuned by Lewis acids addition. One-pot combination of the reductive ring opening and subsequent addition of thiols allows obtaining the cysteine derivatives in practical yields and with high stereoselectivity at the removed β-stereocenter.
Exploring the effectiveness of vitamin B12 complex and alpha-lipoic acid as a treatment for diabetic neuropathy. Protocol for systematic review
Authors:   University of South Africa, Lekhanya Portia Keabetswe , Mokgalaboni Kabelo
Published: May 2022

Review question / Objective: Does Alpha-Lipoic acid increase the uptake of glucose for better glycaemic control? Does vitamin B12 and Alpha-Lipoic acid improve inflammation? The aim of the study is to explore the effectiveness of Vitamin B12 and Alpha-Lipoic Acid as a possible treatment for diabetic neuropathy with major emphasis on markers of inflammation and glucose metabolism. Condition being studied: Diabetic Neuropathy (DN) is a heterogeneous type of nerve damage associated with diabetes mellitus, the condition most often damages nerves in the legs and feet. It presents both clinically and sub-clinically affecting the peripheral nervous system as a result of an increase in glucose concentration which interferes with nerve signalling. After the discovery of insulin as a treatment for Diabetes Mellitus (DM), the prevalence of DN has since increased significantly due to DM patients having a longer life expectancy. It has been estimated that atleast 50% of DM patients will develop DN in their life, with approximately 20% of these patients experiencing neuropathic pain. Nerves are susceptible to changes in glucose concentrations and insulin makes it impossible for neurons to continue regulating glucose uptake.
Dina crnogorensis sp. nov. (Annelida, Hirudinea: Erpobdellidae) – a new leech species from Montenegro
Authors: Grosser Clemens , Pešić Vladimir
Published: May 2022

A yellowish spotted and medium-sized new leech of the family Erpobdellidae with a typical annulation of the genus Dina was found in a spring in the northeastern Montenegro. In the present study, we used an integrative taxonomic approach that combines morphological and DNA barcoding data to describe a new species, Dina crnogorensis sp. nov. Morphologically, the new species is most similar to Dina minuoculata Grosser, Moritz & Pešić, 2007 and Dina serbica Pešić & Grosser, 2022 from the same geographical region, but also to D. orientalis Grosser, Nesemann & Pešić, 2011 from the Near and Middle East. Differences in anatomy and the results of species-delimitation analyses based on COI sequences supported species status of the new species.
Pollution and the risk of premature birth – the current state of knowledge
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Balan Andra Magdalena ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Calinescu Gina ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Campean Doru ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Salmen Teodor ,   Doctoral School, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “N. C. Paulescu” National Institute of Diabetes, Nutrition and Metabolic Disorders, Bucharest, Romania, Mihai Bianca Margareta ,   Filantropia Clinical Hospital, Bucharest, Romania, Dima Vlad ,   Filantropia Clinical Hospital, Bucharest, Romania, Varlas Valentin ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania, Gheorghe Consuela-Madalina ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy, Bucharest,Romania, Zugravu Corina Aurelia ,   Department of Hygiene and Ecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bohiltea Roxana ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Filantropia Clinical Hospital, Bucharest, Romania
Published: May 2022

The potentially dangerous substances present in the geographical area where the pregnant woman works must be well known to healthcare professionals, starting with the family doctor, who is in the front line of prevention, and continuing with all the other specialists. Environmental factors, acting individually or cumulatively, have important effects on human reproduction. With all the recognized progress of modern obstetrics, with the wide use of new technologies in diagnosis, but also with the improvement of the therapeutic arsenal, the percentage of premature newborns has remained constant during the last decades. Studies over the past two decades have shown that preconceptional and prenatal exposure to toxic, environmental agents has a profound and lasting effect on reproductive health. We analyzed the literature to find out the current state of knowledge in the field of the influence of pollution on the risk of premature birth. The study of literature (environmental hygiene, ecology, toxicology, occupational medicine, obstetrics-gynecology, etc.) shows clear causal relationships between certain environmental factors and the risk of premature birth, while for several substances the results are inconclusive.
Latest updates in the histopathological and molecular approach of endometrial carcinoma
Authors:   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Lisievici Antonia Carmen , Georgescu Tiberiu-Augustin ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Pathology, “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Balescu Irina ,   Department of Visceral Surgery, Ponderas Academic Hospital, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital Bucharest, Bucharest, Romania, Gheorghe Consuela-Madalina ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Vladareanu Ioana Teodora ,   Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania
Published: May 2022

Endometrial carcinomas are one of the most frequent carcinomas of the female genital tract. This article aims to highlight the particularities of both histopathological, immunohistochemical and molecular aspects, according to the new World Health Organization (WHO) Classification of endometrial tumors. These tumors can be divided into 4 groups, depending on the mutation that is present, which impacts the prognosis and consequently also the treatment of these patients. Tumors with the best prognosis are part of the low-risk category and are those harboring the POLE mutation, while on the opposite spectrum, TP53 mutated tumors are known to have an aggressive evolution. A thorough literature search has been performed in order to extract the up-to-date information that has been furtherly synthesized. The articles obtained have been reviewed, correlating the histological and molecular features with treatment and prognosis. Although no known reliable immunohistochemical stain can identify the presence of the POLE mutation, molecular analysis is necessary in order to further classify these tumors and to identify the cases that need to be put in the high-risk or high-intermediate risk categories. Considering the good prognosis of carcinomas with POLE mutations, the identification of these cases is recommended due to the possible descaling of treatment.
Pelvic congestion syndrome – case report
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Mihai Bianca-Margareta ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Dorobat Bogdan ,   Department of Interventional Radiology, Emergency University Hospital, Bucharest, Romania, Ducu Ionita ,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania, Georgescu Tiberiu Augustin ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Emergency University Hospital, Bucharest, Romania
Published: May 2022

Pelvic congestion syndrome is unfortunately an often-misdiagnosed disorder that causes chronic pelvic pain in women of fertile age. The main symptoms are represented by chronic pelvic discomfort or pain. This pathology appears to be related to a venous disorder generating pelvic varicosities. There are no standardized diagnosis criteria or treatment guidelines to aid in the management of pelvic congestion syndrome. The therapeutic options consist in medical or surgical treatment, sclerotherapy and endovascular treatment. We present the case of a 33-year-old woman with a severe case of pelvic congestion syndrome, that has affected her both physically and emotionally. The patient received specialized treatment in a Spanish medical unit, with subsequent improved symptoms. We concluded that should be founded specialized centres in our country for the diagnosis and treatment of pelvic congestion syndrome so that these young patients could embrace a normal, painless life.
Modern diagnostic technologies and molecular therapies in oncogenetics
Authors:   Personal genetics, Bucharest, Romania, Sabau Ileana Delia , Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital Bucharest, Bucharest, Romania, Mihai Bianca-Margareta ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Georgescu Tiberiu Augustin ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania, Balescu Irina ,   Department of Visceral Surgery, Ponderas Academic Hospital, Bucharest, Romania, Gheorghe Consuela-Madalina ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Salmen Teodor ,   Doctoral School, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   “N.C. Paulescu“ National Institute of Diabetes, Nutrition and Metabolic Disorders, Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania
Published: May 2022

Advances in cancer genomics research in recent decades have shown that different types of genomic changes cause neoplasms. The last genome was sequenced in 2018, and the information obtained from this technology brought valuable data for research and personalized management of these patients. By the second half of the last decade, it was becoming clearer and clearer that, although the number of genetic changes that could be achieved through targeted therapies was expanding rapidly, there was no genomic technology to identify them all at once. The mismatch repair (MMR) is represented by epigenetic mutations or phenomena in one of the genes of the MMR complex (most commonly MLH1, MSH2, MSH6 and PMS2). As a result, there is an accumulation of DNA abnormalities, especially in the mononucleotides repeats (MNRs) or dinucleotide repeats in the genome, which are known as microsatellites. A correct genetic diagnosis of the cancer patient helps to make the whole case management and directs the multidisciplinary medical team towards targeted molecular therapies.
Saline infusion sonohysterography in endometrial exploration
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Mihai Bianca Margareta ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Georgescu Tiberiu Augustin ,   Department of Pathology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania, Balescu Irina ,   Department of Visceral Surgery, Ponderas Academic Hospital, Bucharest, Romania, Gheorghe Consuela-Madalina ,   Department of Marketing and Medical Technology, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Vladareanu Ioana Teodora ,   Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania
Published: May 2022

Contrast substances have been an extremely important addition in the ultrasonographic examination of the female internal genital organs. Saline infusion sonohysterography consists of the transcervical instillation of fluid into the uterine cavity to improve endometrial visualization while performing a transvaginal ultrasound evaluation. Therefore, benign endometrial pathology such as hyperplasia, but most of all focal lesions like polyps, leiomyomas, or adhesions, as well as suspected malignant pathology such as endometrial cancer, can be better assessed during ultrasound examination. Saline infusion sonohysterography is an important tool for avoiding unnecessary biopsies in postmenopausal women with an apparent thicker endometrium; for women of fertile age, saline infusion sonohysterography can be used to select those females who require further therapeutic procedures, especially in infertility, caused by endometrial pathology. Sonohysterography is very well tolerated by patients, has a minimum degree of discomfort, can be performed without hospitalization and can be easily performed at a reduced cost.
Hysterosalpingo-foam sonography (HyFoSy) in the evaluation of tubal patency
Authors:   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Bohiltea Roxana Elena ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Mihai Bianca-Margareta ,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Ducu Ionita ,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania, Georgescu Tiberiu Augustin ,   Department of Pathology, “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Grigoriu Corina ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, University Emergency Hospital, Bucharest, Romania
Published: May 2022

Women’s infertility represents a public health issue as the birth rate in many countries is more and more diminished. At present, there are many investigation procedures for tubal patency with high accuracy that dictate the further management of infertility cases: hysterosalpingography, hysterosalpingo-contrast sonography, chromopertubation testing during laparoscopy (dye test), magnetic resonance-hysterosalpingography. The traditional gold standard in fertility investigation is represented by laparoscopy with chromopertubation testing, which carries the risk of surgical and anesthesia complications, being a procedure performed as inpatient and the costs are elevated. As ultrasonographic techniques advanced, there has been developed hysterosalpingo-foam sonography, a minimally invasive diagnostic procedure, with imperceptible risks or complications, which simultaneously imports valuable information about the uterine cavity and the tubal patency to the sonographer. Our aim in this paper is to present the statistical results existing in the literature concerning the accuracy of hysteronsalpingo-foam sonography (HyFoSy) in relation to the other examination methods, as well as its advantages.