bluuebunny/crossref_metadata_2025 huggingface dataset:
KEDUDUKAN HUKUM KREDITOR SEPARATIS ATAS JAMINAN KEBENDAAN MILIK GUARANTOR YANG TELAH PAILIT DALAM KEPAILITAN DEBITOR PAILIT
Authors: Ayudinda Pilar Kharisma
Published: September 2023

Perlindungan Hukum dan Kedudukan Kreditor Separatis dalam Hal Terjadi Kepailitan Terhadap Debitor Penjualan jaminan kebendaan dilakukan dengan parate eksekusi yang cara-cara dilakukan dengan penjualan di muka umum atau lelang menurut ketentuan Pasal 185 ayat (1) UU No. 37 Tahun 2004. Kedudukan Hukum Perusahaan Jaminan yang Melepaskan Hak Istimewanya dalam Kepailitan: a. Penanggung Sebagai Debitor Pasal 1 angka 1 UUKPKPU menyatakan bahwa yang dimaksud dengan Debitor adalah orang yang mempunyai utang karena perjanjian atau undang-undang yang pelunasannya dapat ditagih di muka pengadilan. Hapusnya Penanggung Utang Secara umum dalam ketentuan Pasal 1845 KUHPerdata menyatakan bahwa: “Perikatan yang diterbitkan dari penanggungan hapus karena sebab-sebab yang sama, sebagaimana yang menyebabkan berakhirnya perikatan-perikatan lainnya. Tidak ada dasar hukum untuk menuntut dan menempatkan seorang guarantor dalam keadaan pailit pada prinsipnya sifat borgtocht, hanya menempatkan guarantor menanggung pembayaran yang akan dilaksanakan debitor, oleh karena itu yang memikul pembayaran utang yang sebenarnya tetap berada pada diri debitor. Pada saat guarantor berada dalam keadaan tidak mampu kedudukannya sebagai penjamin harus diakhiri dan menggantinya dengan penjamin baru.
Legal protection and the position of separatist creditors in the event of bankruptcy against debtors the sale of material guarantees is carried out by execution parate, which is carried out by public sale or auction according to the provisions of Article 185 paragraph (1) of law no. 37 of 2004. The legal standing of a guarantee company that waives its privileges in bankruptcy a. Insurers as debtors Article 1 Number 1 UUKPKPU states that what is meant by debtors is a person who has a debt due to an agreement or law whose repayment can be collected before the court. The general abolition of the underwriter in the provisions of Article 1845 of the Civil Code states that: “the issued engagement of the underwriter is abolished for the same reason, as caused the termination of other engagements.There is no legal basis for demanding and placing a guarantor in bankruptcy in principle the nature of borgtocht, only placing the guarantor bears the payments that the debtor will carry out, therefore who bears the actual debt payments remains with the debtor. When the Guarantor is in a state of incapacity, his position as guarantor must be terminated and replaced with a new guarantor.
Царь-икона: взгляд П. А. Флоренского
Authors: Паромов Кирилл
Published: September 2023

Тема царской власти находилась в поле зрения П. А. Флоренского, отвечая его главному интересу – проблеме символа. Самодержавие, понимаемое как «феократическая синархия», «освящение человеческой функции власти», «Царем-Христом» творимое (причем въяве – в священном короновании их императорских величеств), «не право, а Дар Божий», ставящий царя «во Христа место», имеет, бесспорно, символическую природу. Обращает на себя внимание явная здесь перекличка с важной для мыслителя темой иконы, иконопочитания. Царь есть живая икона – не метафорически, а буквально. Такова преимущественная специфика его служения.
Первое торговое агентство СССР в Ираке: из истории открытия и деятельности
Authors: Миняжетдинов Ильдар
Published: September 2023

Статья посвящена истории малоизученного эпизода в советско-иракских отношениях, а именно – открытию и деятельности первого торгового агентства СССР в Королевстве Ирак в 1931 г. Этот эпизод рассматривается в контексте отношений трех стран: СССР – Великобритании, СССР – Ирака, Великобритании – Ирака. Значительное внимание в статье уделено описанию факторов, обусловивших заинтересованность правящих кругов Британской империи, имевшей мандат на управление иракской территорией, в налаживании экономического взаимодействия Королевства Ирак с Советским Союзом. Автор также предлагает интерпретацию внешнеполитических мотивов, легших в основу советской торговой экспансии в Ираке в начале 1930-х гг.
Statin-Induced Myopathy
Authors: Sychev D. A. , Ostroumova T. M. , Ostroumova O. D. , Kochetkov A. I. , Batyukina S. V. , Mironova E. V.
Published: September 2023

Scientific relevance. Being the main class of medicinal products for dyslipidaemia treatment, statins are widely used in clinical practice in various patient populations. However, statins can cause statin-associated muscle symptoms (SAMS), which are the most frequent and, in some cases, even life-threatening adverse reactions associated with these medicinal products.

Aim.The study aimed to perform a systematic review of the epidemiology, classification, and physiological pathogenesis of SAMS, risk factors for this complication, and clinical guidelines for primary care physicians regarding the identification and treatment of patients with SAMS.

Discussion.SAMS is an umbrella term that covers various forms of myopathies associated with satin therapy. According to the published literature, the prevalence of SAMS varies considerably and may depend on the study design, inclusion criteria, and the medicinal product used. SAMS has multiple putative pathogenic pathways that include genetically determined processes, abnormalities in mitochondrial function, defects in intracellular signalling and metabolic pathways, and immune-mediated reactions. The main known risk factors for developing SAMS include high-dose statins, drug–drug interactions, genetic polymorphisms, female sex, older age, Asian race, history of kidney, liver, and muscle disease, and strenuous physical activity. Given the lack of universally recognised algorithms for diagnosing SAMS, clinicians should consider the clinical presentation and the temporal relationship between statin therapy and symptoms. Other factors to consider include changes in muscle-specific enzyme levels and, in some cases, the results of blood tests for antibodies to 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase.

Conclusions.To ensure the safety of statin therapy, it is essential to raise clinicians’ awareness of the risk factors for SAMS, indicative clinical and laboratory findings, and the need for dynamic patient monitoring, including the involvement of clinical pharmacologists.
Formation of single-beamdecameters communication channels using digital antenna arrids placed
Authors:   Pacific Higher Naval college named after S.O. Makarov, 690062, Vladivostok, Kamskiy per., 6, Oroshchuk I.M. , Suchkov A.N. ,   Pacific Higher Naval college named after S.O. Makarov, 690062, Vladivostok, Kamskiy per., 6, Kadochnikov M.M. ,   Pacific Higher Naval college named after S.O. Makarov, 690062, Vladivostok, Kamskiy per., 6
Published: September 2023

The article presents the results of studies of the possibility of forming single-beam ionospheric radio channels. These radio channels provide a significant increase in the throughput of decameter communication channels by reducing the time scattering and fading depth of the received signals. For single-beam channels, it is proposed to use antenna arrays placed on an inclined underlying surface. The article shows the possibility of creating such antenna arrays. Their directional properties ensure the selection of one discrete beam. Such antennas have realizable overall dimensions of the structure. This will significantly increase the reliability of the antenna and reduce the cost of its implementation and operation, compared with decameter mast antennas.
It Seemed Like Such a Good Idea at the Time … - Expected and Unexpected Consequences when Athens & Other Major Greek City States Leveraged Philip V to Draw Rome into the Eastern Mediterranean
Authors: Wick David P.
Published: September 2023

The grand theme of the "liberation of Greece" is peculiar in the second and first centuries B.C. by being proclaimed more often by outsiders than by Greeks, and far more often by outsiders than by Athenians. The Athens that ultimately became wholly Roman after the disastrous hostage crisis provoked by Mithridatic forces on the Acropolis in the 80's started down that road by joining with a few other Greek city states to call in Roman aid against Philip V of Macedon in the 190's, and did so, arguably, believing it could leverage a projection of force by a war-weary Roman Republic to make itself again political master of the Greek mainland. To attract Roman aid against the raids of Philip V's Macedon, Athens and its allies had to make both a case that Macedon posed a genuine threat to the eastern Mediterranean (and to Rome, in the aftermath of its war against Hannibal, and Philip's apparent offer to support that war), and the case that it was a key strategic asset for Rome not only in defeating Philip, but also for stabilizing Greece. To play this hand effectively, Athens not only mobilized its legendary propaganda skills, but also worked public feeling hard in its own streets to make Rome feel welcome, and to make Roman intervention feel natural and attractive at home. By playing this hand, Athens also provoked reprisals from Philip, the damage to Athens' physical heritage foreshadowing more extreme destruction a century later when the city would be caught between the insurgents of Mithridates and the renegade Roman forces of Sulla. The Athenian public became, as a result, even more ready to 'be Roman.' At the time, the intent of Athenian politicians to create a specially protected micro-empire for the city on the Greek mainland appeared achievable, but the Roman response, as so often, moved in unexpected directions, and pulled Athens inexorably into the future empire of Rome. Athens’ secondary intention: to become the default educator of the whole ruling culture in Rome’s next generations (it believed it was reaching this goal with the Hellenistic east) would require secondary tactics – including a demonstration using a staged lawsuit in Rome. This study intends to examine the earliest stages of the piecemeal, and only partially intentional, first step of Romanizing in Athens – I addressed a later stage in my study of the Mithridatic hostage crisis on the Acropolis.
O perfil farmacoepidemiológico de uma unidade de terapia intensiva cardiológica como ferramenta para padronização de um serviço de farmácia clínica
Authors: PINHEIRO Thales Oliveira , SILVEIRA Mariana Alves , ZONZINI Fernando Henrique , MENDES Antônio Matoso
Published: September 2023

Objetivo: Descrever o perfil farmacoepidemiológico da Unidade de Terapia Intensiva Cardiológica de um Hospital Universitário Público como forma de contribuir no planejamento, implantação e padronização do Serviço de Farmácia Clínica. Métodos: Estudo transversal e retrospectivo realizado em um hospital público universitário e desenvolvido de acordo com as recomendações da declaração Strengthening the Reporting of Observational Studies in Epidemiology (STROBE). Foram incluídos para análise todas as prescrições realizadas para pacientes internados na UTI Cardiológica (medicamento, dose, via de administração, posologia), além de dados relacionados ao perfil de pacientes e de internamentos (idade, sexo, tempo de internamento). Como premissa de análise foram utilizados indicadores recomendados pela literature em farmacoepidemiologia. Os dados foram extraídos do sistema de informação hospitalar (SIH) para o período de janeiro de 2015 a dezembro de 2019. Na sequência foram compilados e analisados em software Microsoft Office Excel® sendo analisados através de estatísticas descritivas. Resultados: A população do estudo foi composta por 2.157 pacientes (51,3% do sexo masculino), média de idade de 64 anos (DP ± 12,5), com tempo de internamento médio de 4,5 dias. Das admissões 69,4% foram transferidos para outras unidades de internamento, 24,6% receberam alta hospitalar e 6,0% vieram a óbito. Os motivos de internamento foram: síndrome coronariana aguda (44,6%), insuficiência cardíaca (9,7%), arritmias (4,9%), bloqueio atrioventricular (3,7%), estenose valvar (1,9%), choque cardiogênico (0,8%) e parada cardíaca com ressuscitação (0,6%). O total de medicamentos prescritos foi de 175.573, com uma taxa de medicamentos prescritos de 96,2 ao dia. Foram prescritos 468 medicamentos em diferentes apresentações, sendo a Dipirona 1g ampola o item mais prescrito no total de 10.688 unidades (6,1%). Conclusão: O estudo contribuiu para caracterizar o perfil farmacoepidemiológico da Unidade de Terapia Intensiva Cardiológica com o propósito de apresentar dados consistentes que permitirão aperfeiçoar o Serviço de Farmácia Clínica na sua implantação e padronização.
Programa stewardship de antimicrobianos de uso restrito em idosos: estudo de coorte em um hospital quaternário do Brasil
Authors: Da Silva Natalia , FERREIRA Angélica Caroline , NUNES Thauane Pereira , MORET Maria Eduarda , DOS SANTOS José Marcos , SOUZA Débora Bighinzoli , FREITAS Andrea D’avila , FURTADO Paulo Porto , GARNICA Marcia , ARAÚJO Julienne Martins , DA SILVA Natalia Zambão
Published: September 2023

Objetivo: A estratégia denominada stewardship refere-se a um conjunto de intervenções coerentes direcionadas a promover o uso responsável de antimicrobianos. A otimização do uso de antibióticos é fundamental para tratar de forma correta as infecções, mitigar efeitos adversos aos pacientes e combater a resistência bacteriana. Os pilares de um programa de stewardship incluem: i)farmacêutico clínico e infectologista com expertise; ii) medidas educativas aos prescritores, enfermeiros e farmacêuticos; iii) protocolos de profilaxia e terapia estruturados, iv) monitorização de indicadores. Nesse cenário de uso racional de antimicrobianos, os idosos são a população mais susceptível a infecção pela imunocenescência e, portanto, espera-se maior uso de antimicrobianos. Dessa forma, o presente trabalho tem por objetivo avaliar a conformidade da prescrição de antimicrobianos de uso restrito em uma população idosa hospitalizada. Método: estudo observacional, conduzido em um hospital no Rio de Janeiro, Brasil, de janeiro de 2021 a janeiro de 2022. A partir do formulário eletrônico de requisição de antimicrobianos, a conformidade das prescrições era avaliada. A definição utilizada de idoso correspondeu a indivíduos acima de 60 anos, segundo critérios da Política Nacional de Saúde da Pessoa Idosa, Portaria nº 2528, de outubro de 2006. Foram considerados fármacos de uso restrito: carbapenêmicos, polimixina, ceftazidima-avibactam, linezolida, tigeciclina, ceftarolina, equinocandinas e anfotericinas. Resultados: Um total de 1.688 requisições de antimicrobianos de uso restrito foram recebidas, dessas 53% corresponderam a uso em idosos. Neutropenia febril foi mais comum em jovens e unidade de internação foi o setor com maior percentual de antimicrobianos. Outrossim, teicoplanina foi o principal fármaco que necessitou de intervenção. Conclusão: Frente ao aumento da resistência bacteriana, é de extrema importância o uso racional dos antimicrobianos, principalmente nas faixas etárias mais elevadas.
Conciliação medicamentosa farmacêutica em pacientes ambulatoriais com câncer de mama em um hospital de Ensino
Authors: ALMEIDA Celina Santos , SANTOS Milena Jesus , DE ANDRADE Lucimara Mariano , RIBAS Juliana Oliveira , DA COSTA Valmir Paes , SILVA Jaciara Paixão , SOARES Simony Mota , DE AMORIM Fábio Ramalho
Published: September 2023

Objetivo: definir o perfil farmacoterapêutico, interações medicamentosas e intervenções farmacêuticas, reações adversas em pacientes com câncer de mama em uso quimioterapia endovenosa submetidos ao serviço de conciliação medicamentosa farmacêutica. Métodos: caracterizase como observacional transversal sendo submetido e aprovado pelo Comitê de ética, com o número CAAE: 66439017.3.0000.5546. Foram coletados dados a partir das fichas de conciliação medicamentosa e dados de planilhas do serviço de farmácia cínica. Resultados: Foram analisadas 31 conciliações medicamentosas farmacêuticas no período de setembro a outubro de 2022, de um total de 70 pacientes com câncer de mama em quimioterapia endovenosa. A maioria dos pacientes, 97% (n=30) eram mulheres, a média de idade foi 52,51 anos. Quanto a escolaridade, apenas 32,3% (n=10) tinham ensino médio completo. O protocolo AC-T (Doxorrubicina, ciclofosfamida e paclitaxel) foi o mais utilizado (38,7% n=12). A maioria dos pacientes 67,7% (n=21) tinham outras comorbidades sendo hipertensão arterial a mais comum. A média de medicamentos em uso contínuo por paciente foi de 3,38, sendo que 45,2% (n=14) usavam 4 ou mais medicamentos o que caracteriza polifarmácia, além do uso de chás medicinais que foi identificado em 50% (n=12) dos pacientes. Encontrou-se discrepâncias nessas conciliações medicamentosas em 83,9% (n=26) dos pacientes. Além disso, foram observadas 91 interações medicamentosas, sendo uma média de 2,9 interações por paciente. Em relação as intervenções farmacêuticas foram identificadas 24 possíveis intervenções, apresentando uma média de 0,77 intervenções por paciente. A maioria dos pacientes (61,3% n=19) apresentou alguma reação adversa desde a última sessão de quimioterapia. Conclusão: os resultados reforçam a importância do profissional farmacêutico e da reconciliação medicamentosa em pacientes ambulatoriais garantindo a segurança e efetividade dos tratamentos.
Analisis Kinerja Keuangan PT AKR Corporindo Tbk Sebelum dan Sesudah Melakukan Joint Venture
Authors: Wilantari Adela , Anita Widya Febryari
Published: September 2023

This study was conducted to determine and analyze the financial performance of PT AKR Corporindo Tbk. before and after conducting a joint venture as measured using profitability financial ratios consisting of Return On Assets (ROA), Return On Equity (ROE), and Net Profit Margin (NPM). The data used in this study comes from the quarterly consolidated financial statements of PT AKR Corporindo Tbk for the 2013 to 2021 obtained from the official website of the Indonesia Stock Exchange (IDX). Data analysis in this study uses SPSS version 29.0 tools to test data by conducting normality test and the dependent sample t-test. In addition, an analysis was carried out by assessing and comparing the results of financial ratios calculations before and after conducting a joint venture. The results of the study after the SPSS test showed that there were no significant difference in the data used in the study before and after conducting a joint venture, with the results of the analysis at PT AKR Corporindo Tbk after conducting a joint venture is experiencing differences in the level of financial performance, where after conducting a joint venture, PT AKR’s profit continues to increase so that it can be considered effective, which can be seen from the company’s ability to manage costs that need to be incurred properly so that it continues to obtain a large enough operating profit.
Pelatihan Peningkatan Kreativitas Dalam Pembuatan Media Pembelajaran Dengan Menggunakan Canva Pada SMPN 102 Jakarta
Authors: Wijaksono Bahtera Alam , Parulian Dudi , Fazrie Mohammad
Published: September 2023

Pada saat ini pandemic belum dapat dikatakan telah usai beberapa siswa yang terpapar dengan covid tidak dapat melakukan pertemuan tatap muka dengan guru dan teman siswa yang berada disekolah. Membuat para guru harus membuat pembelajaran yang interaktif dan menarik agar siswa yang saat ini tidak dapat bersekolah agar tetap mendapatkan pembelajaran yang sama yang diberikan oleh guru disekolah. Sebelum mengenalkan media pada pembelajaran metode pembelajaran yang digunakan pada kegiatan yaitu observasi,  wawancara, dan demonstrasi pada saat pendampingan berlangsung. tim mengenalkan media pembelajaran via daring yang bisa diberikan oleh guru dengan menggunakan aplikasi canva, dengan aplikasi tersebut memudahkan guru dalam membuat media pembelajaran interaktif, dengan menggunakan media aplikasi canva lebih dapat memudahkan guru dalam membuat materi pembelajaran interaktif yang akan diberikan ke siswa. Oleh karena itulah tim dari Unindra akan melaksanakan pengabdian kepada masyarakat untuk membantu guru dalam  memberikan pemanfaatan canva dalam pembuatan bahan ajar intraktif pada SMP Negeri 102 Jakarta.
Sosialisasi Pemanfaatan Kulit Manggis (Garciana Mangostana L.) Sebagai Teh Herbal dan Serbuk Gula Kristal
Authors: Widiyatun Fita , Sumarni Ria Asep , Mulyaningsih Neng Nenden
Published: September 2023

Kulit mangis mempunyai manfaat yang sangat besar. Sayangnya, tidak semua orang mengetahui manfaat-manfaat dari kulit manggis tersebut dan bagaimana cara mengolahnya agar dapat dikonsumsi. Pada kesempatan ini, kami melakukan pengabdian kepada masyarakat berupa sosialisasi pengolahan kulit manggis menjadi teh herbal kulit manggis dan serbuk gula kristal kulit manggis. Kegiatan dilaksanakan di Ibu-ibu PKK Blok H, Pamulang Park Residence. Kegiatan berupa sosialisasi manfaatan dan proses pengolahan dari kulit manggis. Kegiatan berjalan dengan lancar dan baik, serta diperoleh hasil tingkat kepuasan peserta dari kegiatan yaitu 98,57 %. Hal ini menunjukkan bahwa peserta sangat puas dengan kegiatan yang dilaksanakan.
TO THE QUESTION OF TACIT KNOWLEDGE: KANTIAN IDEAS IN THE FORMATION OF THE CONTEXT OF THE PROBLEM
Authors:   Siberian Transport University, Novosibirsk, Russia, Martishina Natalya I. ,   Novosibirsk State University of Economics and Management, Novosibirsk, Russia
Published: September 2023

The article traces a line in the development of epistemology, which led to the formation of the concept of tacit knowledge. The author demonstrates that the formation of this area of research is based on the solution to the problem of prerequisite knowledge found by I. Kant: a priori foundations of knowledge are such prerequisites for knowledge that are not the meaningful ideas but the forms of knowledge organization. The tacit knowledge as non-reflexive, non-explicit knowledge that exists on the periphery of cognitive activity functionally corresponds to just such a component of cognition; its significant part is made up of ontogenetically a priori prerequisites for cognition. The tacit knowledge is irreducible to the personal knowledge; on the contrary, the category of collective tacit knowledge exists. The article provides an overview of the possible sources of tacit knowledge identified in various areas of the study of the problem.
RECEPTION OF IDEAS OF WESTERN SOCIAL PHILOSOPHY OF THE 19TH-EARLY 20TH CENTURIES IN SPIRITUAL AND ACADEMIC THEISM AS A FACTOR IN THE DEVELOPMENT OF ORTHODOX ETHICAL AND ANTHROPOLOGICAL DOCTRINE
Authors:   Far Eastern State Transport University, Khabarovsk, Russia, Novikova Natalia V.
Published: September 2023

The article deals with the attitude of Orthodox doctrine about the person and society to a number of European and American social concepts, including "social evangelism," "positivist sociology" (using the example of G. Spencer), Nietzscheanism, "organistic" con-cepts of social development. It is concluded that, despite the desire to find their interpretation of social processes based on the patristic tradition, representatives of spiritual and academic philosophy used the conceptual ideas of Catholic and Protestant au-thors, especially the latter's criticism of positivism and Nietzscheanism when considering social issues. In addition, the article indi-cates a close connection between the Orthodox doctrine of society and the study of the ethical and social nature of man.
PROJECT ACTIVITY IN THE IMPLEMENTATION OF THE STATE YOUTH POLICY IN UNIVERSITIES
Authors:   North-West Institute of Management – Branch of Russian Presidential Academy of National Economy and Public Administration, Saint Petersburg, Russia, Tyurina Yulia A.
Published: September 2023

The article discusses the use of project activities as a mechanism for building educational systems, organizing student associations, creating conditions for the socialization and self-realization of students in the context of the implementation of state youth policy in higher education in Russia. The article presents the experience of using project activities in the formation of design competencies and ensuring the effectiveness of organizing work with youth in two universities (Branch of RANEPA and the Far Eastern State Transport University).
PSYCHOLOGICAL SERVICE OF A TRANSPORT UNIVERSITY: FROM THE EXPERIENCE OF THE PSYCHOLOGICAL CENTER OF THE FAR EASTERN STATE TRANSPORT UNIVERSITY
Authors:   Far Eastern State Transport University, Khabarovsk, Russia, Donkan Irina M. , Taranets Roman Y. ,   Far Eastern State Transport University, Khabarovsk, Russia
Published: September 2023

The article presents a theoretical substantiation of the activities of the services of psychological support of the educational process in the system of higher education in general, as well as in the system of transport education in particular. The creation of psychologi-cal services in Russian universities is being updated in the context of the modern state agenda. The practical experience of the Psy-chological Center of the Federal State Budgetary Educational Institution of Higher Education "FESTU" is considered: integration into the management system and organizational structure of the university, the content of psychological support for participants in the educational process, the content and main areas of activity in working with students (diagnostics, counseling, correctional, work, education, prevention, crisis direction). The issues of interdepartmental interaction are covered on the example of work with healthcare organizations, transport, public organizations, etc.
CAREER GUIDANCE PRACTICES IN EDUCATIONAL INSTITUTIONS OF THE LENINGRAD REGION
Authors:   North-West Institute of Management – Branch of Russian Presidential Academy of National Economy and Public Administration, Saint Petersburg, Russia, Lyashko Svetlana V. , Klyuev Anatoliy V. ,   North-West Institute of Management – Branch of Russian Presidential Academy of National Economy and Public Administration, Saint Petersburg, Russia
Published: September 2023

The article is devoted to the analysis of career guidance practices implemented in educational institutions of the Leningrad region. It presents some results of an empirical study carried out in schools of the Leningrad Region by the Center for Sociological Research of the North-Western Institute of Management of the Russian Academy of National Economy and Public Administration under the President of the Russian Federation in 2022 Region are presented. On the basis of the data obtained, the features of career guid-ance activities in educational organizations were identified, the effectiveness and efficiency of established practices were analyzed.
АКСИОЛОГИЧЕСКАЯ МОДЕЛЬ «НОВЫЙ ЧЕЛОВЕК» В КИТАЕ
Authors:   Saint Petersburg State University of Economics, Saint Petersburg, Russia, Dugarova Svetlana B.
Published: September 2023

The article is devoted to the problem of man in the anthropological dimension in China, where Confucianism was the main spiritual factor of Chinese culture. Against the background of ongoing significant changes in the traditional way of thinking of the Chinese, new value principles have not yet been formed, but old traditional attitudes are being destroyed. Therefore, awareness of the hu-man problem in the anthropological dimension comes to the fore. In addition to modernization in the economic sphere, China is developing its own concept of human modernization, which differs significantly from the Western theory of modernization. In con-nection with the ongoing development of the country, it was important to turn to the traditional concept of morality, on the basis of which a certain axiological model of the “new man” is formed. This model is formulated on the basis of the fundamental ideas of Chinese traditional culture, the content of which is related to the formation of a comprehensively developed person. The anthropo-logical model of the "new man" comes from the Confucian principle "man at the core", which is aimed at the comprehensive devel-opment of man, proceeds from the fundamental interests of the people, promotes development aimed at satisfying the material and spiritual needs of the people, their political and cultural interests. "A person at the core" implies a development in which a per-son is declared the highest value, and relationships between people are built on the basis of respect, understanding and care. The axiological development of man in China is on a par with the political, economic and social construction of the country. In this situa-tion, it becomes necessary to educate a person with a higher level of organization of consciousness, able to adapt to any changes.
P.I. SMIRNOV’S RESPONSE TO HIS BOOK’S ("COMPREHENSION OF RUSSIA. THE SOCIOLOGIST’S VIEW.") REVIEW BY R.L. LIVSHITS
Authors:   Free researcher, Saint Petersburg, Russia, Smirnov Petr I.
Published: September 2023

The article analyzes the review of the book by P.I. Smirnov "Comprehension of Russia. The sociologist’s view." (reviewed by R.L. Livshits). Certain parts of the review are either accepted or refuted. The author of the book explains his position on the cognition problems of global and Russian societies. The principle of methodology convergence of the natural and social sciences is defended. The article criticizes the Marxist statements about the number and structure of socio-economic formations – the law of the corre-spondence between production relations and the character and level of development of the productive forces, etc. The usefulness of the concept of "ideal type" for describing the evolution of society is proved, it is proposed to consider the influence of social per-sonality types on processes and events in Russia and the USSR, etc.
SPIRITUAL COGNITION IN THE DIALOGUE OF CULTURES
Authors:   Peoples' Friendship University of Russia, Moscow, Russia, Nizhnikov Sergei A.
Published: September 2023

The article analyzes various methodological approaches to solving the problem of the dialogue of cultures. Based on A. Torchinov's work, the article discusses criticism of Eurocentrism and Orientalism, stereotypes in the assessment of Eastern cultures and prob-lems that arise when externally comparing the teachings of the East, in particular Buddhism and some Western philosophical con-cepts (Berkeley, Hume, Husserl). The author specially analyzes the comparative method developed by M.K. Mamardashvili, based on the metatheory of consciousness under the influence of Vijnanavada. The ontologism of consciousness underlying all cultures allows reaching a universal understanding of culture as an all-human phenomenon. For Mamarashvili, it is consciousness that is a culture-forming phenomenon. The possibility of entering the communicative space of the dialogue of cultures through conscious-ness is connected with its transcending nature. This transcendence leads beyond the limits of the mental states of both the specific "I" and cultural characteristics, revealing the immanent depths of universal human culture. Mamardashvili considered himself a Kantian and saw in transcendental philosophy an ontological basis for the dialogue of cultures. The author expresses the conviction that based on the universalism of spiritual cognition as a product of the "Axial age" it is pos-sible not only to build a dialogue of cultures, but also a deep mutual understanding between them. Spiritual cognition also embraces the work with consciousness, on which Mamardashvili insisted, and is able to find common ground between theistic (Christianity, Islam) and non-theistic (East: Taoism, Confucianism, Buddhism) cultures on the basis of transcending, revealing the immanent basis – the spiritual archetype of humanity, uniting Truth, Goodness and Beauty.
The Safety of Anti-VEGF Treatment, in the Context of the Retinal Nerve Fibre Layer, in Patients with Wet Age-Related Macular Degeneration: A Review
Authors: Wichrowska Małgorzata , Goździewska Ewa , Kocięcki Jarosław
Published: September 2023

Anti-vascular endothelial growth factor (VEGF) drugs are widely used in modern ophthalmology, especially in treating macular disorders like age-related macular degeneration or diabetic macular edema. Protocols for such treatments include repeated administration of intravitreal injections, with the volume of drug injected into the vitreous chamber seemingly high enough to cause an increase in intraocular pressure. Hence, questions might arise if such therapeutic approaches are safe for ocular tissue. Moreover, anti-VEGF compounds may theoretically harm the retinal nerve fibers due to the inhibition of VEGF and its neuroprotective effects. Thus, this manuscript aims to review the literature regarding studies evaluating the retinal nerve fiber layer (RNFL) in eyes receiving anti-VEGF treatment due to age-related macular degeneration. The RNFL was chosen as a subject of this review, as it is the innermost retinal layer exposed to the direct action of intravitreally administered drugs. The results of the available studies remain inconclusive. Most researchers seem to confirm the safety of the anti-VEGF treatment in wet age-related macular degeneration, at least regarding the retinal nerve fiber layer. However, some authors noticed that the influence of anti-VEGFs on RNFL could become apparent after more than thirty injections. Nonetheless, the authors of all studies agree that further, long-term observations are needed to help clinicians understand the effect of anti-VEGF treatment on the dynamics of changes in the thickness of retinal nerve fibers in patients with the wet form of age-related macular degeneration.
Inhibition of TRAP1 Accelerates the DNA Damage Response, Activation of the Heat Shock Response and Metabolic Reprogramming in Colon Cancer Cells
Authors: Bhasin Nobel , Dabral Prerna , Senavirathna Lakmini , Pan Sheng , Chen Ru
Published: September 2023

Background: Colorectal cancer (CRC) is one of the major causes of cancer-related mortality worldwide. The tumor microenvironment plays a significant role in CRC development, progression and metastasis. Oxidative stress in the colon is a major etiological factor impacting tumor progression. Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial member of the heat shock protein 90 (HSP90) family that is involved in modulating apoptosis in colon cancer cells under oxidative stress. We undertook this study to provide mechanistic insight into the role of TRAP1 under oxidative stress in colon cells. Methods: We first assessed the The Cancer Genome Atlas (TCGA) CRC gene expression dataset to evaluate the expression of TRAP1 and its association with oxidative stress and disease progression. We then treated colon HCT116 cells with hydrogen peroxide to induce oxidative stress and with the TRAP1 inhibitor gamitrinib-triphenylphosphonium (GTPP) to inhibit TRAP1. We examined the cellular proteomic landscape using liquid chromatography tandem mass spectrometry (LC-MS/MS) in this context compared to controls. We further examined the impact of treatment on DNA damage and cell survival. Results: TRAP1 expression under oxidative stress is associated with the disease outcomes of colorectal cancer. TRAP1 inhibition under oxidative stress induced metabolic reprogramming and heat shock factor 1 (HSF1)-dependent transactivation. In addition, we also observed enhanced induction of DNA damage and cell death in the cells under oxidative stress and TRAP1 inhibition in comparison to single treatments and the nontreatment control. Conclusions: These findings provide new insights into TRAP1-driven metabolic reprogramming in response to oxidative stress.
Honey Mushroom, Armillaria mellea (Agaricomycetes) and Its Fermentation Products Target Regulation of OAT1/OAT3 Proteins to Reduce Hyperuricemia in Mice
Authors: Li Zheng-Long , Wang Shu-Min , Wang Huan
Published: September 2023

Background: Disorders of purine metabolism are the main cause of hyperuricemia. Current drugs for the treatment of hyperuricemia usually cause a degree of cardiovascular damage. Methods: This study aimed to investigate the therapeutic effects of Armillaria mellea fruiting body (AFB), Armillaria rhizomorph (AR) and Armillaria mellea fermentation product (after rhizomorphs removal) (AFP) on hyperuricemic mice. The hyperuricemia mouse model was established by oral administration of potassium oxonate 0.9 g⋅kg-1 and hypoxanthine 0.5 g⋅kg-1 for two weeks. Starting from the third week, the intragastric administration of the intervention drug group was as follows: Allopurinol 0.013 g⋅kg-1, AFB (3.9 and 7.8 g⋅kg-1), AR (3.9 and 7.8 g⋅kg-1), AFP (1.95 and 3.9 g⋅kg-1) once daily for 14 days. Results: Results showed that AFB, AR, and AFP reduced the contents of serum uric acid, serum creatinine, and blood urea nitrogen in hyperuricemic mice and the mechanism of action might be through up-regulation of the expression levels of organic anion transporter 1/organic anion transporter 3 proteins in kidney tissue. AR and AFP both exhibited better uric acid-lowering effects than AFB, which may be due to the higher purine content of AFB. Conclusions: Armillaria mellea and its fermentation products can treat hyperuricemia by up-regulating OAT1 protein and OAT3 protein, reducing uric acid content in mice.
THE PROSPECT OF BROWN SEAWEED BIOGELS USE IN THE SYSTEM OF MEASURES TO HEALTH PRESERVATION OF LABORATORY WORKERS
Authors:   FSBEI HE «Pacific State Medical University» of the Ministry of Health of the Russian Federation, Vazhenina A.A.
Published: September 2023

An experimental uncontrolled study was conducted to study the possibility of using biogels from brown seaweed in the system of measures to preserve the health of employees of testing laboratories of the Far Eastern Federal District with harmful working conditions. A specialized food product «Laminal (biogel from seaweed)» was used. The absence of cytotoxic effects was revealed, a statistically significant 4‑fold decrease (p<0.001) in the number of epithelial cells with nuclear pathology (cells with micronuclei, including non-nuclear ones) was noted, a significant decrease (p<0.001) in the number of cells with signs of keratinization was recorded at the end of Laminal intake according to the scheme: before the start of the work shift 30 minutes before taking food for 30 g of biogel for four working weeks, from employees of testing laboratories of sanitary-hygienic and microbiological profile. The use of a specialized food product «Laminal (biogel from seaweed)» may have the potential as one of the preventive measures for leveling the adverse effects of harmful production factors and correcting the condition of the epithelium of the oral mucosa in employees of the district's testing laboratories.
MEDICAL DOCUMENT FLOW IN PRACTICAL WORK OF AN OCCUPATIONAL PHYSICIAN
Authors:   FBSI «Ufa research institute of occupational medicine and human ecology», Ahmetshina V.T. , Ruzakov V.O. ,   FBSI «Yekaterinburg Medical Research Center for prevention and health protection of industrial enterprises workers» of Rospotrebnadzor, Onischenko N.P. ,   SBHI «Scientific research institute - Regional clinical hospital № 1 named after professor S.V. Ochapovcky» of the Ministry of health of Krasnodarsky kray
Published: September 2023

This article is concerned of the special aspects of the medical electronic document flow between employers and regulatory authorities in the sphere of medicine during medical examination conducted by the medical organizations. There has been made a review of the currently available electronic document flow systems, organizational and technical requirements in the systems of legally relevant medical document flow. The main results of the practical usage of both the medical examination automation system and the medical electronic document flow with regulatory authorities are stated in this work.
PROBLEMS OF TRAINING SPECIALISTS IN OCCUPATIONAL HYGIENE
Authors:   FSBEI HE «North-Western State Medical University named I.I. Mechnikov» Ministry of Health (Russia), Baltrukova T.B. , Sokolova L.A. , Ivanova O.I.
Published: September 2023

This article summarizes the experience of teaching occupational hygiene at the Northwestern State Medical University. Discussed various vectors of training specialists, methods used in the educational process, problems in training and ways to solve them.
PROFESSIONAL SUITABILITY EXAMINATION AS TOOL FOR EMPLOYEES HEALTH PRESERVATION
Authors:   BHI of Voronezh Region «Voronezh City Clinical Hospital №1», Besko V.A. , Mamchik N.P. , Samodurova N.Yu. ,   FSBEI HE «Voronezh N.N. Burdenko State Medical University» of the Ministry of Health of the Russian Federation
Published: September 2023

In recent years, the health characteristics of those employed in hazardous working conditions have been featured by a decrease in the level of occupational morbidity with a simultaneous increase in the number of general somatic polyethological diseases. This determined the topicality of industrial-related morbidity leading to the loss of vocational fitness of the employees. The purpose of the work was to study the expert activity of the health authorities of the primary and specialized levels of the regional occupational pathology service to develop the technology of the expert activity increasing its effectiveness. Method of retrospective analysis of medical organizations reports and the health authorities protocols at the Center of Occupational Pathology has been applied in the work. Results of comparative analysis of the health authorities' work for eight years showed that at the Center of Occupational Pathology the level of diseases detection included in the approved list of contraindications was four times higher than the level of detection at all medical organizations of the region. Application of the technology developed at the Center, including allocation of the employees requiring vocational fitness assessment to the groups; routing of the patients ensuring the cooperation of the Center, primary care organizations and the employer, has made it possible to set up a dispensary observation group. Vocational fitness has been restored to 30% of this group employees. Conclusions are drawn about the necessity to develop the expert activity of the occupational pathology service as a tool for the prevention of industrial-related morbidity leading to the loss of vocational fitness of the employees taking into account the leading organizational and coordinating role of the Regional Center of Occupational Pathology.
Rethinking The United Nations – Nigeria Partnership Towards Girl Child Education and Gender Equality Reforms: A Systematic Review
Authors: Egberi Anthony Ejue , Madubueze Madumelu Harrison Christian
Published: September 2023

The study focused on the United Nations-Nigeria cooperation in correcting the skewed male-dominated educational system in the Northern states of Nigeria, characterized by extremist beliefs, inequitable education, and gender inequality. As a result, the report contends that the prevalence of sex discrimination exacerbates concerns about female child education and gender inequality. The paper investigated inequitable quality education (SDGs 4) and gender equality (SDGs 5). Furthermore, the study extracts the UN-Nigeria partnership in transforming the Northern states' male-dominated educational system. It also looked at the factors contributing to inequitable quality education and gender equality and the numerous UN-Nigeria partnerships for girl-child education and gender equality. The study collected data from secondary sources and analyzed the data using content analysis. The paper raised several questions and specifically examined issues such as: why parents in the Northern States believe that girl child education is irrelevant, why all adduction is aimed at girls and the role and challenges of the UN-Nigeria partnership in reforming the male-dominated educational system in the Northern states of Nigeria. Finally, the study concluded with policy recommendations.
Learning Action Cell as A Channel for Teacher’s Professional Competence in Elementary Schools in the Divisions of Laguna
Authors: Conde Liezl Ayuso , Yazon Alberto D , Tan Consortia S , Bandoy Marcial M
Published: September 2023

This study investigated the relationship between the Learning Action Cell (LAC) level and teachers' professional competence. It utilized quantitative correlational design to assess and analyze the data of elementary teachers and how the LAC empowers and capacitates them on the various techniques and methodologies to be competent enough to deliver effective teaching facilitation. The 619 teachers respondents from nearby three (3) Schools Divisions were assessed on how LAC training every year improved their competencies. The finding proved that the more LAC sessions conducted, the higher the teacher’s competencies gained. The quantitative correlation denoted that the quality of implementation of the Learning Action Cell training based on the study result was very high. It visibly manifested in the total impact of LAC training is enhancing and empowering teachers' professional competencies. This study proved that it is an essential component of the education system as they provide a platform for collaboration, professional development, problem-solving, and continuous learning among teachers.
PROJECT METHOD IN STEM EDUCATION USING ARDUINO SOFTWARE AND HARDWARE PLATFORM
Authors: Voronkin Oleksii , Lushchin Sergiy
Published: September 2023

Formulation of the problem. One of the promising methods of training in STEM education is the method of projects. The projected method in STEM education determines the relevance and research nature of the topic of the project, ensuring the interconnection of theoretical knowledge with practice, practical implementation of the results of the project. The project, as a means of implementing STEM education, allows you to integrate knowledge from different subject industries when solving real tasks, the creation of existing layouts, which causes their practical use.
Materials and methods. Methods of analysis and systematization of scientific and pedagogical literature were used; generalization of the results of domestic and foreign experience in the use of a prose method in the STEM education using the ARDUino software and hardware platform. The experimental method of creating an active physiotherapy laser device for treatment of the runny nose is presented. A software modeling is used to simulate a device with the design of the Arduino Uno board.
Results. The example of the implementation of the STEM project "Development of a physiotherapeutic laser device for the treatment of runny nose" demonstrates how it is possible to integrate many different-level, didactic, and research tasks. A generalized description of the main structural elements of the Arduino Uno board is given. A typical algorithm for familiarizing yourself with the operation of the Arduino board is formulated. The main sections of the physics course are indicated, the knowledge of which is fundamental for implementing the project. It is shown how using a bit matrix of laser states allows the creation of cyclic irradiation modes that periodically change each other. An example of a code processing a bit matrix of laser states is provided. The sketch controls the modes of the semiconductor laser, displays the exposure time on the liquid crystal display, and emits a sound signal at the end of the exposure time set by the potentiometer. A fragment of the simulation modeling of a physiotherapy device in the Tinkercad Circuits environment is presented.
Conclusions. The practical experience of using the project method in STEM education has shown that it allows students to investigate a real problem actively, apply the acquired knowledge in practice, and develop cooperation, communication, and critical thinking skills. Implementation of the project contributes to the combination of various activities, such as cognitive, creative, practical, and research, as well as the development of thinking skills, motivation, and responsibility for one's actions. Implementing the project method makes it possible to provide high-quality training for specialists in natural sciences who can effectively apply their knowledge and skills in practical situations and contribute to the further development of STEM fields in Ukraine.