bluuebunny/crossref_metadata_2025 huggingface dataset:
Paradoxical association of symptomatic cerebral edema with local hypoperfusion caused by the ‘watershed shift’ after revascularization surgery for adult moyamoya disease: a case report
Authors: Yu Jin , Hu Miao , Yi Lei , Zhou Keyao , Zhang Jianjian , Chen Jincao
Published: September 2019

Superficial temporal artery–middle cerebral artery anastomosis is generally considered as an effective method in improving damage associated with intracerebral occlusions in moyamoya disease. Hemodynamic changes caused by revascularization are the cause of many postoperative complications. Of the 186 consecutive surgeries for moyamoya disease at our hospital from 2015, we herein presented one case of adult-onset moyamoya disease that manifested symptomatic local cerebral edema and local hypoperfusion caused by the ‘watershed shift’. A 67-year-old woman presented with limb numbness on the right side and underwent superficial temporal artery–middle cerebral artery anastomosis, resulting in neurological dysfunction and the formation of a reversible high-signal lesion at left frontotemporal lobes on T2-weighted images along with a decrease in perfusion values on 123I N-isopropyl-p-iodoamphetamine single-photon emission computed tomography, while the anastomotic vessel was patent on magnetic resonance angiography. This phenomenon of hypoperfusion area (left frontotemporal lobe) remote to anastomotic site (left temporal lobe area) led to the diagnosis of the ‘watershed shift’ phenomenon. In light of the hypoperfusion induced by ‘watershed shift’, the patient was treated with fluid replacement. With the gradual recovery of perfusion, the patient presented significantly improvement both on the magnetic resonance imaging findings and neurological symptoms. In conclusion, regional cerebral edema with hypoperfusion, possibly due to cerebral ischemia and the ‘watershed shift’ phenomenon, may be another novel entity that needs to be considered as a potential complication after extracranial–intracranial bypass for moyamoya disease.
Giant cell tumor of bone: Unusual features of a rare tumor
Authors: Mohaidat Ziyad M , Al-jamal Hisham Z , Bany-Khalaf Audai M , Radaideh Ahmad M , Audat Ziad A
Published: September 2019

Giant cell tumor of bone is a benign tumor with an aggressive behavior. Its typical subarticular location and high recurrence risk can be associated with significant morbidity. Although benign, it can rarely metastasize especially to the lungs. Also, it can be multicentric in less than 1% of patients. Late malignant transformation, although rare, can occur with a very poor prognosis. This series reports on these unusual and challenging features and management considerations of giant cell tumor of bone.

This retrospective study included review of the medical records of patients with a confirmed histopathological diagnosis of giant cell tumor of bone.

A total of 25 patients (16 females and 9 males) with a mean age of 34.5 years were included; 22 had primary tumors, while 3 were referred with recurrent tumors. Pain was the most common presenting symptom. Most patients had grade III tumors. Tumors around the knee were the most common. Multicentric tumors were detected in three patients. Twenty-three patients (20 primary giant cell tumor of bone and 3 with recurrence) received treatment. Most patients (15/23) were treated with intralesional curettage with or without adjuvants. Seven patients had wide excision. Recurrence was seen in 45% (9/20) of primary giant cell tumor of bone especially with difficult anatomical locations. Most recurrences occurred more than 4 years after treatment. Pulmonary nodules were detected in four patients; two of them showed resolution during follow-up. One patient developed secondary sarcoma transformation with a fatal outcome.

Giant cell tumor of bone was more common in females. Long bones were more affected, especially around the knee. Intralesional curettage was the most frequently used treatment. Recurrence was associated with inadequate tumor resection (especially in difficult anatomical location), younger age, male gender, and advanced local tumor grade. Denosumab can be used in the treatment of pulmonary metastasis, multicentric and recurrent giant cell tumor of bone. Due to late recurrence and malignant transformation, a prolonged follow-up is warranted.
Health of left-behind children in China: Evidence from mediation analysis
Authors: Lu Yao , Yeung Wei-Jun Jean , Liu Jingming , Treiman Donald J.
Published: September 2019

Internal migration in China has resulted in large numbers of left-behind children. Despite growing attention paid to this population, existing research has not systematically addressed the mediating mechanisms linking parental migration to children's health. The present study examines the influences of migration on the health of left-behind children in China and the mediating channels, using data from a new nationally representative survey. We compare three groups of rural children aged 3–15 years ( N = 2473): those who were left behind by both parents, those who were left behind by one parent and those living with both non-migrant parents. Results show that the health of rural children left behind by both parents (but not by one parent) is worse than the health of children living with both parents. The health disadvantage of these children is mediated by their caregivers' poor health status and caregiving practices. These mediating factors not only have a direct impact on child health but also exert an indirect impact by shaping children's nutritional intakes. Contrary to conventional wisdom, monetary remittances are not a significant mechanism linking migration to child health.
Loss of Ambulatory Independence Following Low-Energy Pelvic Ring Fractures
Authors: Kugelman David N. , Fisher Nina , Konda Sanjit R. , Egol Kenneth A.
Published: September 2019

Introduction:

Lateral compression type 1 (LC1) pelvic ring fractures make up 63% of all pelvic ring injuries. This fracture pattern is typically seen in older patients. The purpose of this study is to assess the ambulatory status of individuals sustaining LC1 fractures at long-term follow-up and what specific characteristics, if any, effect this status or functional outcomes.

Methods:

Over a 2-year period, all pelvic ring injury at 2 hospitals within one academic institution was queried. One hundred sixty-one low-energy LC1 pelvic fractures were identified.

Results:

Fifty patients were available for long-term outcomes (mean: 36 months). Long-term functional outcomes (mean follow-up: 36 months) as measured by SMFA subgroup scores were demonstrated to be 3 times higher in patients currently using assistive devices for walking ( P = .012). Increased age ( P = .050) was associated with the continued use of assistive walking devices. Of the patients who did not use an ambulatory device prior to LC1 injury, 5 (11.6%) sustained a fall or medical complication within 30 days of the index pelvic fracture; this was associated with the current use of an assistive ambulatory device ( P = .010). Forty-three (86%) patients didn’t use an assistive ambulatory device prior to sustaining the LC1 fracture. Seven (14%) patients utilized assistive devices both before and after the LC1 injury. Thirteen (26%) patients, who did not utilize assistive ambulatory devices prior to their injury, necessitated them at long-term follow-up.

Discussion:

Surgeons should be aware of these associations, as they can implement early interventions aimed at patients at risk, for assistive device use, following LC1 pelvic fractures.

Conclusion:

More than a quarter of the patients sustaining an LC1 pelvic fracture continue to use an aid for ambulation at long-term follow-up. Older age, complications, and falls within 30 days of this injury are associated with the utilization of an assistive ambulatory device.
“I Can’t Stand Women’s Sports”: The Perception of Women’s Sports by Polish Sports Journalists
Authors: Organista Natalia , Mazur Zuzanna , Lenartowicz Michał
Published: September 2019

This article analyzes the opinions of Polish male ( n = 18) and female ( n = 18) sports journalists on the representation of women’s sports in media coverage. The surveyed journalists represented journalists from national television stations, radio stations, and press and Internet media. Some of them were working simultaneously in various mass media outlets. In-depth interviews were conducted in various locations in Poland in 2018. An analysis of the journalists’ views from 36 semi-structured interviews indicated a general consensus among the surveyed sports journalists, both male and female, on the inferior status of women’s sports and women’s sports coverage, a negation of need to realign the inequitable coverage of women’s sports and the perception that sports are a neutral institution with respect to gender. The investigated female sports journalists presented more negative and straightforward views on women’s sports than their male colleagues. This article also indicates the minority status of female sports journalists in Poland and their process of socialization in the profession; it discusses the first male socializing agents that introduced and influenced the female journalists with respect to sports as factors that may be responsible for the journalists’ biased belief in the subordinate nature of women’s sports in general and their secondary position in sports media.
Comparing Clinical Outcomes After Subacromial Spacer Insertion Versus Other Reconstruction Methods in the Treatment of Irreparable Massive Rotator Cuff Tears
Authors: Oh Joo Han , Park Joo Hyun , Jeong Hyeon Jang , Rhee Sung-Min
Published: September 2019

Background:

Previous studies on subacromial spacer (SAS) insertion have been limited to case series that did not compare the effectiveness of this technique with other techniques.

Hypothesis:

Outcomes after SAS insertion for the treatment of irreparable massive rotator cuff tears (IMRCTs) will be similar to those of other techniques.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

This retrospective study was based on data collected from patients who underwent correction of IMRCTs between January 2010 and October 2017. Group 1 patients (n = 17) received SAS insertion with or without partial repair; group 2 patients (n = 36) were treated with other techniques (isolated partial repairs or bridging grafts). Preoperative tear size and global fatty degeneration index values were evaluated. Range of motion, visual analog scale for pain, American Shoulder and Elbow Surgeons (ASES) score, Constant score, Simple Shoulder Test (SST), Disabilities of the Arm, Shoulder and Hand score, and acromiohumeral distance (AHD) were assessed preoperatively and at final follow-up at least 2 years after the surgery (range, 24-60 months). In both groups, ultrasonographic examination was performed at 3 and 6 months postoperatively, and magnetic resonance imaging (MRI) was performed at 1 year.

Results:

Tear size and preoperative global fatty degeneration index were not significantly different between the groups (all P > .05). There were no differences in functional scores between the groups at final follow-up (all P > .05). AHD was maintained at final follow-up in group 1 (mean ± SD: 6.2 ± 2.1 mm [postoperatively] vs 6.7 ± 2.3 mm [final follow-up]; P = .678), and there was no difference compared with group 2 (7.2 ± 3.2 mm; P = .244). Patients with retears in group 2 (23 of 36, 63.9%) had lower ASES ( P = .041) and SST ( P = .027) scores at final follow-up when compared with patients in group 1. Six patients (35.3%) in group 1 had partial repairs; these patients had better external rotation at 90° ( P = .047), better SST scores ( P = .036), and higher AHDs at final follow-up ( P = .046) than those in group 1 who had no repair. Three patients (50%) showed retears of partially repaired tendons on MRI. Of 13 patients (76.5%) in group 1 with postoperative MRI, 12 (92.3%) showed fibrotic tissue in the subacromial space not seen preoperatively.

Conclusion:

There was no difference in outcomes between SAS and the other reconstruction methods for treating IMRCTs. However, given the high retear rate associated with other techniques and poor functional outcomes after retear, SAS insertion could be a viable option for treating IMRCTs.
Prevalence of Medial Ulnar Collateral Ligament Surgery in 6135 Current Professional Baseball Players: A 2018 Update
Authors: Leland Devin P. , Conte Stan , Flynn Nancy , Conte Nicholas , Crenshaw Ken , Wilk Kevin E. , Camp Christopher L.
Published: September 2019

Background:

As the incidence of ulnar collateral ligament (UCL) surgery continues to rise rapidly, an update on the current prevalence and demographics in professional baseball players is warranted.

Hypothesis:

The prevalence of UCL reconstruction in Major League Baseball (MLB) and Minor League Baseball (MiLB) players will be higher than that previously reported, and the increase in prevalence will be most notable in MiLB pitchers.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

During the 2018 baseball season, an online questionnaire regarding a history of UCL surgery was distributed to the certified athletic trainers of all 30 MLB organizations. These trainers then administered the survey to all players within their organizations, including MLB, MiLB (AAA, AA, High A, Low A, High Rookie, Low Rookie), and Dominican Summer League (DSL) players. Demographics were compared between MLB, MiLB, and DSL players. Results of this 2018 survey were compared with previously published data from the 2012 season to assess the change over time.

Results:

There were 6135 professional baseball players who completed the survey (66% response rate). The prevalence of UCL reconstruction in all MLB and MiLB players was 13% (637/4928), while the prevalence in DSL players was 2% (20/1207) ( P < .001). The prevalence in all MLB and MiLB players (13%) and pitchers (20%) both increased significantly from 2012 ( P < .001). MLB pitchers reported a higher prevalence of UCL reconstruction than did MiLB pitchers (26% vs 19%, respectively; P < .001). In 2018, the prevalence of UCL reconstruction has increased significantly in MiLB pitchers (19% vs 15%, respectively; P < .001) and pitchers aged 21 to 30 years (22% vs 17%, respectively; P < .001) compared with 2012. Additionally, United States–born pitchers were more likely to have undergone UCL reconstruction compared with Latin America–born pitchers (23% vs 13%, respectively; P < .001).

Conclusion:

The prevalence of UCL reconstruction has increased significantly in professional baseball players over the past 6 years from 10% to 13%. Ultimately, the prevalence of UCL reconstruction has increased most significantly since 2012 in MiLB pitchers, pitchers aged 21 to 30 years, and pitchers born in the United States.
Study on Risk and Influencing Factors of Hypertension in Chinese Elderly
Authors: Song Shijia , Li Handong
Published: September 2019

Objective:

The incidence of hypertension in elderly patients in China and influencing factors.

Method:

Based on the baseline data in 2013 from the China Health and Retirement Longitudinal Study (CHARLS), this study used the practical incidence estimator (PIE) method to estimate incidence of hypertension, and applied Cox regression to determine the relationship between the hypertension and influencing factors.

Results:

In general, the incidence of hypertension in elderly patients decreased with age, and the risk of hypertension in females was significantly higher than that in males. The cumulative incidence of hypertension for an individual, who is hypertension-free before the age of 65 years, could reach 86.21% (95% confidence interval [CI] = [85.09%, 87.87%]) during one’s survival time. The status of drinking, pension and work, education background, place of residence, and gender were verified to influence the onset of hypertension.

Conclusion:

For Chinese elderly, developing hypertension during their life span has almost become an inevitable event, which may become a huge social burden in China.
Heme-regulated eIF2α kinase in erythropoiesis and hemoglobinopathies
Authors: Chen Jane-Jane , Zhang Shuping
Published: September 2019

Chen and Zhang review the role of eukaryotic initiation factor 2α (eIF2α) in regulating the balance between protein synthesis and iron availability as part of the integrated stress response in erythroid cells.
Impact of rurality on diabetes screening in the US
Authors: Tran Phoebe , Tran Lam , Tran Liem
Published: September 2019

Background

Due to the high prevalence of diabetes risk factors in rural areas, it is important to identify whether differences in diabetes screening rates between rural and urban areas exist. Thus, the purpose of this study is to examine if living in a rural area, rurality, has any influence on diabetes screening across the US.

Methods

Participants from the 2011, 2013, 2015, and 2017 nationally representative Behavioral Risk Factor Surveillance System (BRFSS) surveys who responded to a question on diabetes screening were included in the study (n = 1,889,712). Two types of marginal probabilities, average adjusted predictions (AAPs) and average marginal effects (AMEs), were estimated at the national level using this data. AAPs and AMEs allow for the assessment of the independent role of rurality on diabetes screening while controlling for important covariates.

Results

People who lived in urban, suburban, and rural areas all had comparable odds (Urban compared to Rural Odds Ratio (OR): 1.01, Suburbans compared to Rural OR: 0.95, 0.94) and probabilities of diabetes screening (Urban AAP: 70.47%, Suburban AAPs: 69.31 and 69.05%, Rural AAP: 70.27%). Statistically significant differences in probability of diabetes screening were observed between residents in suburban areas and rural residents (AMEs: − 0.96% and − 1.22%) but not between urban and rural residents (AME: 0.20%).

Conclusions

While similar levels of diabetes screening were found in urban, suburban, and rural areas, there is arguably a need for increased diabetes screening in rural areas where the prevalence of diabetes risk factors is higher than in urban areas.
Renal glucosuria is associated with lower body weight and lower rates of elevated systolic blood pressure: results of a nationwide cross-sectional study of 2.5 million adolescents
Authors: Fishman Boris , Shlomai Gadi , Twig Gilad , Derazne Estela , Tenenbaum Alexander , Fisman Enrique Z. , Leiba Adi , Grossman Ehud
Published: September 2019

Background

Gene coding mutations found in sodium glucose co-transporters (SGLTs) are known to cause renal glucosuria. SGLT2 inhibitors have recently been shown to be effective hypoglycemic agents as well as possessing cardiovascular and renal protective properties. These beneficial effects have to some extent, been attributed to weight loss and reduced blood pressure. The aim of the current study was to evaluate the prevalence of renal glucosuria amongst a large cohort of Israeli adolescents and to investigate whether renal glucosuria is associated with lower body weight and lower blood pressure values.

Methods

Medical and socio-demographic data were collected from the Israeli Defense Force’s conscription center’s database. A cross-sectional study to evaluate the association between conscripts diagnosed as overweight [BMI percentiles of ≥ 85 and < 95 and obesity (≥ 95 BMI percentile)] and afflicted with renal glucosuria was conducted. In addition, we assessed the association of renal glucosuria with elevated diastolic and systolic blood pressure. Multinomial regression models were used.

Results

The final study cohort comprised 2,506,830 conscripts of whom 1108 (0.044%) were diagnosed with renal glucosuria, unrelated to diabetes mellitus, with males twice as affected compared to females. The adjusted odds ratio for overweight and obesity was 0.66 (95% CI 0.50–0.87) and 0.62 (95% CI 0.43–0.88), respectively. Adolescents afflicted with renal glucosuria were also less likely to have an elevated systolic blood pressure of 130–139 mmHg with an adjusted odds ratio of 0.74 (95% CI 0.60–0.90).

Conclusions

Renal glucosuria is associated with lower body weight and obesity as well as with lower rates of elevated systolic blood pressure.
Shiga toxin producing Escherichia coli-associated diarrhea and hemolytic uremic syndrome in young children in Romania
Authors: Falup-Pecurariu Oana , Lixandru Raluca Ileana , Cojocaru Emanuela , Csutak Katalin , Monescu Vlad , Muhsen Khitam , Falup-Pecurariu Cristian , Cohen Daniel
Published: September 2019

Background

Diarrheagenic Escherichia coli (E. coli) is an important cause of diarrheal diseases in both developing countries and industrialized countries. An outbreak of hemolytic uremic syndrome (HUS) in young children from southern Romania was reported in early 2016 and was attributed to Shiga toxin producing E. coli (STEC) O26 infection. The aim of this study was to determine the prevalence, demographic and clinical characteristics of STEC infections in children hospitalized with diarrhea in Brașov in the central region of Romania. We also described the occurrence of HUS among hospitalized children, close in time to the 2016 HUS outbreak in southern Romania.

Methods

A prospective study was conducted between March and December 2016 among 722 children aged 1–30 months hospitalized with acute diarrhea. Stool samples obtained from patients with diarrhea were tested for the presence of Shiga toxin type 1 (STX1) and type 2 (STX2) by an immunochromatographic assay, and other enteropathogens. Demographic and clinical information on cases of HUS diagnosed in the same hospital was obtained from medical records.

Results

Overall 46/722 (6.4%) children (mean age 10.3 months, 32.6% females) hospitalized with diarrhea tested positive for STX1 or STX2; of these 79% were positive for both STX1 and STX2, 16% for STX2 only, and 5% for STX1 only. Bloody diarrhea, vomiting and fever were documented in 32.6%, 52.1% and 50.0%, respectively of patients with STEC infection. Eleven confirmed HUS cases (mean age 20 months, five females) were identified between 2014 and 2016 with prodromal diarrhea reported in 10 of them. Three of the 11 HUS patients required hemodialysis.

Conclusions

STEC prevalence among young children with diarrhea in Romania was high and the risk of HUS is emerging. The establishment of a systematic laboratory-based surveillance program including identification of the circulating STEC strains coupled with epidemiological investigation of HUS patients is warranted to determine the source and mode of transmission of STEC and prevent of STEC-associated diarrhea and HUS.
Ovarian abscess caused by Salmonella enterica serovar Typhi: a case report
Authors: Getahun S. Aneley , Limaono Josese , Ligaitukana Raween , Cabenatabua Orisi , Soqo Vika , Diege Raape , Mua Mikaele
Published: September 2019

Background

Typhoid fever is a human-specific disease caused by a bacterium, Salmonella enterica subspecies enterica serovar Typhi. It is transmitted through ingestion of contaminated food or water. It is mostly diagnosed by blood culture. Salmonella Typhi usually manifests as a febrile illness with bacteremia after initial entry through the gastrointestinal route, but it can occasionally cause significant disease in extraintestinal sites. We report a case of a girl in Fiji with a right ovarian abscess infected by Salmonella Typhi.

Case presentation

A 14-year-old iTaukei (indigenous Fijian) girl presented to our hospital with abdominal pain of 1 month’s duration. Two days prior to her admission, she developed high-grade fever and nausea and had one episode of vomiting. On presentation, she appeared unwell; she was tachycardic (116 beats per minute) and febrile (38.8 °C). Her abdominal examination revealed generalized tenderness. Other examination findings were normal. The provisional diagnosis of abdominal sepsis led to an emergency laparotomy during which an enlarged right ovary was found to be spontaneously discharging pus. The ovary was incised and drained, and the patient was commenced on intravenous ceftriaxone 1 g twice daily, cloxacillin 1 g four times daily, and metronidazole 500 mg three times daily. She recovered promptly and was discharged to home on the sixth postoperative day. The purulent material from the ovary grew Salmonella Typhi.

Conclusion

Extraintestinal infections caused by Salmonella Typhi are rare but can cause severe and life-threatening disease. Our patient had a prolonged history of abdominal pain and was found to have a ruptured right ovarian abscess due to Salmonella Typhi. Ovarian abscesses in girls who are not sexually active are not associated with pelvic inflammatory disease and suggest local or hematogenous spread. This case report may increase health workers awareness to include common and endemic infections in the differential diagnosis of unusual clinical presentations to help the initiation of appropriate investigation and management as quickly as possible.
Chromatin topology, condensates and gene regulation: shifting paradigms or just a phase?
Authors: Mir Mustafa , Bickmore Wendy , Furlong Eileen E. M. , Narlikar Geeta
Published: September 2019

In the past decade, two major advances in our understanding of nuclear organization have taken the field of gene regulation by storm. First, technologies that can analyze the three-dimensional conformation of chromatin have revealed how the genome is organized and have provided novel insights into how regulatory regions in the genome interact. Second, the recognition that many proteins can form membraneless compartments through liquid-liquid phase separation (LLPS) has challenged long-standing notions of how proteins within the nucleus are organized and has offered a tantalizing general mechanism by which many aspects of nuclear function may be regulated. However, the functional roles of chromatin topology and LLPS in regulating gene expression remain poorly understood. These topics were discussed with great fervor during an open discussion held at a recent workshop titled ‘Chromatin-based regulation of development’ organized by The Company of Biologists. Here, we summarize the major points covered during this debate and discuss how they tie into current thinking in the field of gene regulation.
RNA detection with high specificity and sensitivity using nested fluorogenic Mango NASBA
Authors: Abdolahzadeh Amir , Dolgosheina Elena V. , Unrau Peter J.
Published: September 2019

There is a pressing need for nucleic acid–based assays that are capable of rapidly and reliably detecting pathogenic organisms. Many of the techniques available for the detection of pathogenic RNA possess one or more limiting factors that make the detection of low-copy RNA challenging. Although RT-PCR is the most commonly used method for detecting pathogen-related RNA, it requires expensive thermocycling equipment and is comparatively slow. Isothermal methods promise procedural simplicity but have traditionally suffered from amplification artifacts that tend to preclude easy identification of target nucleic acids. Recently, the isothermal SHERLOCK system overcame this problem by using CRISPR to distinguish amplified target sequences from artifactual background signal. However, this system comes at the cost of introducing considerable enzymatic complexity and a corresponding increase in total assay time. Therefore, simpler and less expensive strategies are highly desirable. Here, we demonstrate that by nesting NASBA primers and modifying the NASBA inner primers to encode an RNA Mango aptamer sequence we can dramatically increase the sensitivity of NASBA to 1.5 RNA molecules per microliter. As this isothermal nucleic acid detection scheme directly produces a fluorescent reporter, real-time detection is intrinsic to the assay. Nested Mango NASBA is highly specific and, in contrast to existing RNA detection systems, offers a cheap, simple, and specific way to rapidly detect single-molecule amounts of pathogenic RNA.
INFLUENCE OF RARE-EARTH ON THE MICROSTRUCTURE AND MECHANICAL PROPERTIES OF HIGH MANGANESE STEEL UNDER IMPACT LOAD
Authors: Nguyen Duong Nam , Nguyen Duong Nguyen , Pham Mai Khanh
Published: September 2019

In this paper, the influence of rare earth (RE) on the microstructure and mechanical properties of austenitic high manganese steel (HMnS) Mn15Cr2V were investigated. The results showed that the microstructure, hardness and impact strength of RE modification sample is finer and better than non-modified sample. Under the effect of impact load, the hardness and the depth of the work-hardening layer of the modified steel was higher than that of the non-modified steel, thereby, the value of microhardness in the surface of the modified sample was 420 HV while it was only 395 HV in the non-modified sample. The value of the impact strength of the modified sample was up to 132 J/cm2 compared to the non-modified sample is only 115 J/cm2. Moreover, after impact load, the austenite nanoparticles had been found out on the surface of this steel, this is the cause of the increasing of mechanical properties in this steel.
Postinfectious Irritable Bowel Syndrome After Campylobacter Infection
Authors: Scallan Walter Elaine J. , Crim Stacy M. , Bruce Beau B. , Griffin Patricia M.
Published: September 2019

OBJECTIVES:

Postinfectious irritable bowel syndrome (PI-IBS) is an important sequela of Campylobacter infection. Our goal is to estimate the incidence of Campylobacter-associated PI-IBS in the United States.

METHODS:

Data from January 1, 2010 to December 31, 2014, were obtained from the MarketScan Research Commercial Claims and Encounters Database. We identified patients with an encounter that included an International Classification of Diseases, Ninth Revision, Clinical Modification diagnosis code for “intestinal infection due to Campylobacter” (008.43) and individually matched them (on age group, sex, and length of enrollment) to a group of persons without a diagnosed Campylobacter infection (non-cases). The primary outcome of interest was a new diagnosis of IBS (International Classification of Diseases, Ninth Revision, Clinical Modification 564.1).

RESULTS:

Our final matched cohort included 4,143 cases and 20,491 non-cases. At 1 year, the incidence rate of IBS was 33.1 and 5.9 per 1,000 among cases and non-cases, respectively, with an unadjusted risk ratio of 5.6 (95% confidence interval [CI]: 4.3–7.3). After adjusting for healthcare utilization, the Cox proportional hazard ratio was 4.6 (95% CI: 3.5–6.1). Excluding those who received an IBS diagnosis within 90 days, the 1-year incidence rate of IBS was 16.7 and 3.9 per 1,000 among cases and non-cases, respectively, with an unadjusted risk ratio of 4.3 (95% CI: 3.0–6.2).

DISCUSSION:

Persons with a Campylobacter infection have a much higher risk of developing IBS compared with those not diagnosed with Campylobacter infection. The burden of Campylobacter-associated PI-IBS should be considered when assessing the overall impact of Campylobacter infections.
Generation of Silver Nanoparticles by the Pin-Hole DC Plasma Source with and without Gas Bubbling
Authors: Kozáková Z. , Krčma F. , Čechová L. , Simic S. , Doskočil L.
Published: September 2019

Silver nanoparticles were produced using the pin-hole discharge generated by dc non-pulsing high voltage directly in silver nitrate solutions. Sodium nitrate was alternatively added to increase solution conductivity and decrease input energy for the discharge breakdown. Argon or oxygen was bubbled through the discharge region. Comparative experiments were evaluated by UV-VIS spectrometry. Formation of silver nanoparticles with the average size of 100 nm was confirmed by SEM/EDS analysis.
State of Art and Challenges for the Calculation of Radiative and Transport Properties of Thermal Plasmas in HVCB
Authors: Cressault Y. , Teulet Ph. , Baumann X. , Vanhulle G. , Reichert F. , Petchanka A. , Kabbaj N.
Published: September 2019

This paper is focused on the state-of-the-art and challenges concerning the thermophysical properties of thermal plasmas used in numerical modelling devoted to high voltage circuit breakers. For Local Thermodynamic Equilibrium (LTE) and Non-Local Thermodynamic (NLTE) and/or Chemical Equilibrium (NLCE) plasmas, the methods used to calculate the composition, thermodynamic, transport and radiative properties are presented. A review of these last data is proposed and some comparisons are given for illustrations.
Análisis del nivel de institucionalización de los servicios civiles municipales del gran Mendoza
Authors: Llano Mercedes , Bilbao Mirian , Belmonte Alejandro
Published: September 2019

El objetivo del trabajo es analizar el nivel de institucionalización de los servicios civiles de los seis (6) municipios que conforman el Gran Mendoza a partir de la aplicación de una escala bipolar de politización/profesionalización. Las características estructurales presentan una alta variabilidad en términos tamaño de la burocracia, composición, nivel de flexibilización y peso fiscal del empleo público en los casos seleccionados. Asimismo, el cálculo del índice de institucionalización de los servicios civiles municipales (IISCM) en las comunas del área metropolitana mendocina arroja un aún frágil nivel de implantación del mérito en el orden local. El IISCM promedio asciende a 2,7 puntos, posicionándose 5 de los casos de mitad de la escala hacia el extremo que denota mayor politización de las burocracias. Sólo la Ciudad de Mendoza (3,1) alcanzó puntuaciones mínimamente más cercanas al polo que representa niveles más elevados de profesionalización administrativa.
Programas de transferencia Condicionada frente a frente: Los casos de Chile, Paraguay y Colombia (2000–2012)
Authors: Osorio Gonnet Cecilia , Vergara Hermosilla José Miguel
Published: September 2019

La ola de difusión de los Programas de Transferencia Condicionada (PTC) en América Latina generó un grupo de programas sociales con características comunes, pero también ciertas divergencias. Este artículo ofrece una mirada comparada a los programas de tres países: Chile, Colombia y Paraguay, analizando sus componentes y la coherencia interna entre los fines y medios de las iniciativas. Los hallazgos evidencian diversidad en los programas, diferentes grados de coherencia entre los fines perseguidos y medios utilizados, así como indicios de transferencia de componentes entre países. Todo ello plantea desafíos para la comprensión de los procesos de formulación de políticas sociales en América Latina.
TRADITIONAL RISK FACTORS FOR CARDIOVASCULAR DISEASES IN SYSTEMIC SCLEROSIS AND THEIR RELATIONSHIP TO STRUCTURAL CHANGES OF THE HEART
Authors: Saad E. O. , Ananyeva L. P. , Novikova D. S. , Alekperov R. T.
Published: September 2019

Objective: to determine the frequency of traditional risk factors (TRFs) for cardiovascular diseases (CVD) in patients with systemic sclerosis (SS) and to analyze their relationship to the clinical manifestations of SS, as well as to structural changes, as evidenced by echocardiography (EchoCG).

Subjects and methods. The investigation enrolled 125 patients with SS and 50 sex- and age-matched, apparently healthy individuals included in a control group. Standard electrocardiography was performed in all and EchoCG – in 121 patients. The Systematic Coronary Risk Evaluation (SCORE) scale was used to assess the risk of fatal CVD in 100 patients with SS and in 47 control individuals within 10 years.

Results and discussion. The frequency of TFRs in patients with SS was not significantly different from that in the control group, except for the occurrence of hypercholesterolemia and increased body mass index (BMI). In SS, BMI >25 kg/m2 was observed significantly more often and the frequency of hypercholesterolemia was lower than in the controls (p <0.018). Hypertension and diabetes mellitus were slightly more frequently encountered in SS patients than in the controls, but this difference was insignificant. Taking into account the Russian Society of Cardiology (RSC) guidelines, the cardiovascular risk (CVR) was assessed with the SCORE scale. A very high CVR was much more common in SS and a moderate CVR was much more frequently seen in the control group. There were no substantial differences in the frequency of low and high CVRs. SS is characterized by the increased frequency of high total CVD risk as compared to the controls. Hypertension, overweight, and over 50 years of age were associated with more obvious structural heart disease.

Conclusion. TRFs make a substantial contribution to the formation of a high CVR in patients with SS, promoting the development of atherosclerosis and its complications. Assessment of TGFs in SS patients will facilitate identifying patients at high risk for cardiovascular death and timely prescribing therapy. Hypertension is an important TGF that in SS is associated with considerable structural changes in the heart; therefore adequate blood pressure control is of importance in improving SS prognosis especially in patients older than 50 years.
Less Frequent Neurologic Complications of Anticoagulant Therapy
Authors: Taláb Radomír , Waberžinek Gerhard
Published: September 2019

One of the less frequent complications of anticoagulant therapy is damage to the femoral and sciatic nerves due to bleeding. This report presents two cases and discusses the pathogenetic mechanism and treatment of this medical problem.
The influence of the grafted aryl groups on the solvation properties of the graphyne and graphdiyne - a MD study
Authors: Berisha Avni
Published: September 2019

The mechanism of the adsorption and grafting of diazonium cations onto the surface of graphyne and graphdiyne was investigated using Density Functional Theory (DFT). The adsorption energy (both in vacuum and water as solvent) of the phenyl diazonium cation was evaluated at three different positions of the graphyne and graphdiyne surface. Moreover, the lowest energy adsorption sites were used to calculate and plot Non-covalent Interactions (NCI). The Bond Dissociation Energy (BDE) results (up to 66 kcal/mol) for the scission of the phenyl group support the remarkable stability of the grafted layer. As both of these materials are non-dispersible in aqueous solution, in this work through the use of Molecular Mechanics (MM) and Molecular Dynamics (MD) we explored also the effect of the grafted substituted aryl groups derived from aryldiazonium salts onto the solvation properties of these materials.
Numerical approach to MHD flow of power-law fluid on a stretching sheet with non-uniform heat source
Authors: Mishra Satya Ranjan , Baag Sushma , Dash Gouranga Charan , Acharya Manas Ranjan
Published: September 2019

In the present study the flow of power-law fluid, due to a stretching sheet embedded in a saturated porous medium, is considered. This study also accounts for the variable thermal conductivity in the process of heat transfer along with dissipation due to Joule heating. The thermal conductivity is assumed to vary as a linear function of temperature. The similarity transformation is used to convert nonlinear partial differential equations to non linear ordinary equations. The numerical method, Runge-Kutta method with shooting technique has been applied to solve the resulting equations. The power-law fluid exhibits a dual property in the presence of magnetic field. The limiting cases n → 0 and n → ∞ have been discussed. For large n the solution becomes unstable which leads to flow instability(Shown in the graph).
Space as the Stage: Understanding the Sacred Landscape Around the Early Celtic Hillfort of the Glauberg
Authors: Posluschny Axel G. , Beusing Ruth
Published: September 2019

The Early ‘Celtic’ hillfort of the Glauberg in Central Germany, some 40 km northeast of Frankfurt, is renowned for its richly furnished burials and particularly for a wholly preserved sandstone statue of an Early Iron Age chief, warrior or hero with a peculiar headgear – one of the earliest life-size figural representations north of the Alps. Despite a long history of research, the basis for the apparent prosperity of the place (i.e., of the people buried here) is still debated, as is the meaning of the settlement site as part of its surrounding landscape. The phenomenon known as ‘princely sites’ is paralleled in the area north and west of the Alps, though each site has a unique set of characteristics. This paper focusses on investigations and new excavations that put the Glauberg with its settlement, burial and ceremonial features into a wider landscape context, including remote sensing approaches (geophysics and LiDAR) as well as viewshed analyses which define the surrounding area based on the Glauberg itself and other burial mounds on the mountains in its vicinity.
Relationship between Periodontal Variables and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease (COPD)
Authors: Moeintaghavi Amir , Mohammadzadeh Lari Shahrzad , Shiezadeh Farid , Mohammadian Zakieh , Tajik Shamim , Nasrabadi Nahid
Published: September 2019

Background. The present study investigated the relationship between certain periodontal variables and severity of disease in COPD patients. Methods. The present cross-sectional study included 50 patients suffering from COPD. Lung function examination, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), FEV1/FVC, SpO2, and Modified Medical Research Council (MMRC) Dyspnea Scale were performed. Periodontal clinical examination index included probing depth (PD), attachment loss (AL), gingival index (GI) and plaque index (PI). A quality of life validated index, the COPD assessment test (CAT index), was also calculated. Results. The FEV1 and FVC indices showed a significant negative correlation with PI and AL variables only. The COPD assessment test (CAT) index showed a significant but positive correlation with PI and AL variables only. The SpO2 index presented a significant negative correlation with GI and AL variables. The FEV1/FVC ratio was found to have a negative correlation with PD and AL variables. It is worth noting that MMRC exhibited no significant relationship with any of the periodontal variables. The only variable that was significantly different (P=0.022) among the three smoking groups was the FVC index. The FVC value was significantly higher in the group of subjects who smoked more than 10 cigarettes per day versus the non-smoking group (P=0.017). Conclusion. Based on the findings of this study, in view of the relationship between periodontal variables and respiratory indices in the course of COPD, early treatment of periodontal diseases, might considerably reduce the severity of COPD.
Vestibular incisional subperiosteal tunnel access versus coronally advanced flap with connective tissue graft for root coverage of Miller’s class I and II gingival recession: A randomized clinical trial
Authors: Mansouri Saeed Sadat , Moghaddas Omid , Torabi Narjes , Ghafari Katayoun
Published: September 2019

Background and aims. This study aimed to compare the clinical efficacy of vestibular incisional subperiosteal tunnel access (VISTA) with subepithelial connective tissue graft versus a coronally advanced flap (CAF) with subepithelial connective tissue graft for the treatment of gingival recession defects. Materials and methods. This randomized clinical trial was performed on 24 recession defects that were bilaterally Miller’s class I or II in the maxillary canine and premolar area. One quadrant in each patient was selected randomly to receive VISTA (test group) or CAF (control group) with connective tissue graft. Clinical parameters measured at baseline and at 3- and 6- month postoperative intervals included recession width (RW), recession depth (RD), keratinized tissue width (KTW), clinical attachment level (CAL) and probing depth (PD). Results. Healing was uneventful in both the test and control groups. At the 6-month follow-up, there was a significant decrease in RD, RW and CAL and an increase in KTW in both the test and control groups. The PD remained unchanged. At 3 and 6 months, no statistically significant differences were found between VISTA and CAF for root coverage and clinical attachment gain. Mean root coverage (MRC) was 70.69% and 67.22% in the test and control group, respectively. VISTA demonstrated higher frequency of complete root coverage (CRC) compared to CAF: 50% vs. 33% (P<0.05). The mean KTW was 2.4±0.7 mm at the test and 2.7±0.8 mm at the control sites (P>0.05) Conclusion. VISTA, as a minimally invasive approach, can enhance root coverage, KTW and clinical attachment gain; therefore, it can be used as a substitute for CAF with connective tissue graft as a gold standard for root coverage.
Genome-Wide Analysis of Cell Cycle-Regulating Genes in the Symbiotic Dinoflagellate Breviolum minutum
Authors: Cato Michael L , Jester Hallie D , Lavertu Adam , Lyman Audrey , Tallent Lacey M , Mitchell Geoffrey C
Published: September 2019

A delicate relationship exists between reef-building corals and their photosynthetic endosymbionts. Unfortunately, this relationship can be disrupted, with corals expelling these algae when temperatures rise even marginally above the average summer maximum. Interestingly, several studies indicate that failure of corals to regulate symbiont cell divisions at high temperatures may underlie this disruption; increased proliferation of symbionts may stress host cells by over-production of reactive oxygen species or by disrupting the flow of nutrients. This needs to be further investigated, so to begin deciphering the molecular mechanisms controlling the cell cycle in these organisms, we used a computational approach to identify putative cell cycle-regulating genes in the genome of the dinoflagellate Breviolum minutum. This species is important as an endosymbiont of Aiptasia pallida—an anemone that is used as a model for studying coral biology. We then correlated expression of these putative cell cycle genes with cell cycle phase in diurnally growing B. minutum in culture. This approach allowed us to identify a cyclin/cyclin-dependent kinase pair that may function in the G1/S transition—a likely point for coral cells to exert control over algal cell divisions.
Mapping of the Sex Determining Region on Linkage Group 12 of Guppy (Poecilia reticulata)
Authors: Dor Lior , Shirak Andrey , Kohn Yair Yaacov , Gur Tal , Weller Joel Ira , Zilberg Dina , Seroussi Eyal , Ron Micha
Published: September 2019

Poecilia reticulata is one of the most popular ornamental fish species with a higher demand for males due to their large colorful fins. The objectives of this study were mapping of the sex-determining (SD) region on linkage group 12 of guppy, and identification of a sex specific marker. We generated eight polymorphic microsatellite markers distributed along the distal 5.4 Mbp sequence of the previously identified SD region on linkage group (LG) 12. The markers were tested for association with sex in 156 individuals of the Red Blonde and Flame strains, and 126 progeny of four full-sibs Red Blonde families. A male-specific allele was found for microsatellite gu1066 at position of 25.3 Mbp on LG12 for both strains, and gu832 at position 24.4 Mbp for the Flame strain. Thus, a region of 0.9 Mbp between these markers, harboring 27 annotated genes, was selected for analysis. Based on association of copy number variation and sex determination we mapped a duplicated region between LGs 9 and 12, of 1.26 Mbp, containing 59 genes on LG12. The common interval between the segment bounded by gu1066 and gu832, and the duplicated region of 0.43 Mbp on LG12 harbors 11 genes of which 6 have multiple copies (54%). Growth arrest and DNA damage inducible gamma-like (GADD45G-like) is a plausible positional and functional candidate gene for its role in male fertility. We characterized the genomic structure of the gene in guppy, and found two isoforms; but no sex-biased differences were evident in genomic sequence and gene expression.