bluuebunny/crossref_metadata_2025 huggingface dataset:
What is tragic about the Pre-Platonic philosophers? On Nietzsche’s Philosophy in the Tragic Age of the Greeks
Authors:   IFILNOVA/NOVA University Lisbon, Lima Paulo Alexandre
Published: February 2025

This essay aims to understand the tragic character of the first philosophers in Nietzsche’s Philosophy in the Tragic Age of the Greeks. It claims that their tragicity should be understood based on the categories of personality and grandiosity in so far as they are related to these philosophers’ experience of the monstrous and their heroic response to this experience through the artistic production of concepts. The first philosophers carry out a symbolic mediation of the presence of the monstrous in culture, which is so important to preserve the connection between culture and life, in such a way that they make it possible for their culture to live a life in abundance. Nietzsche is aware that the categories used by human beings in general have a fictional and intrinsically artistic nature. When considering the first philosophers, he consciously makes use of fictional and artistic categories (where the monstrous is included too). Like these philosophers, he asserts himself as a tragic hero who artistically produces this kind of categories in response to his own experience of the monstrous in modern culture. The tragicity of the first philosophers is, therefore, fundamentally related to them being an inspiring ideal created by Nietzsche the tragic philosopher.
Reflections on the Similarities between the Language of the Mysteries and Patristic Literature
Authors:   Baltic Federal University (Russia), Kozhevnikov Mikhail
Published: February 2025

The article analyzes similarities between the core terms of Christian apologetic and patristic literature as well as those found in texts related to ancient mystery cults. First, we examine the examples of common vocabulary (common to the Mysteries, Hellenistic Judaism and Christianity) which cannot be convincingly designated as borrowings – words with the meaning of “secrecy” or “concealment” (μυστήριον). However, we then find examples of the use of mystery vocabulary by Christians accompanied by their metaphorical meaning found in the mysteries context – for example, the likening of the Easter Vigil to the Eleusinian torchlight procession, δᾳδουχία (both rites are held at night and precede the culmination – the celebration of the Resurrection of Christ and the epopteia in Eleusis). In other cases, the use of some “common” words by Christian authors in a rarely encountered meaning proves difficult to explain without admitting borrowing from mystery usage (this primarily concerns the word σύμβολον in the Creed). Finally, examples of similar imagery associated with light and fear are examined, the similarity of which lies not only in the lexicological plane, but also in the assumed universal features of religious experience.
Glass intaglio with the portrait of Silenus from Galilee: stylistic analysis, provenience, dating, and meaning
Authors:   National Treasures Department of the Israel Antiquities Authority, Tarkhanova Svetlana , Arubas Benyamin ,   Tel Hai College, Israel
Published: February 2025

A small glass intaglio with the impressed portrait of Silenus was found in Galilee some years ago. By its technical and stylistic characteristics, it dates back to the Persian–Early Hellenistic period. Based on the general historical, cultural, and economic conditions of the period, it is supposed to have originated from one of the Greek islands, where the cult of Silenus emerged at that time and was imported to the Land of Israel. Amazingly, in the collection of E. Borowski, the exact glass duplicate of the gem with Silenus was encountered in the course of research (currently located in the Bible Land Museum). Such coincidences very rarely occur in research on small ancient objects. The discovery of this Pagan gem in Galilee sheds light on the spread of the Dionysiac cults and the development of the religious and economic links between the Land of Israel and the Classical Greek world.
Economic Barriers of Autism Spectrum Disorder: A Bibliometric Analysis
Authors: Arı Ahmet Aydın , Afşar Kerim Eser , Yazıcı İrem , Gökçek Muhammet Eyüp
Published: February 2025

The purpose of this study was to analyse the literature on economic barriers related to autism spectrum disorder (ASD) using bibliometric methodology. It was also aimed to contribute to the understanding of research trends on the economic aspects of ASD. The relevant literature was obtained from the WoS database and analysed using the Bibliometrix package via R Studio. The dataset covered the years 2003-2024 and 95 articles were accessed. The selected documents were analysed and visualized using MS Excel and Biblioshiny applications. The findings showed that the first article about the relevant literature in the WoS database was written in 2003 and the articles written in the last 5 years accounted for more than half of the literature. Information on the most publishing journals, universities and countries and the most cited publications were also obtained. The most repeated words were child and economic burden with 28 repetitions, while expenditures and prevalence shared the second place with 14 repetitions each. Additionally, the word recruitment ranked highly with 7 repetitions in the relevant articles, which was consistent with the topic of the study. It is anticipated that the findings of this analysis will provide direction and a foundation for future research.
Bibliometric Analysis of Green Finance Research Using Science Mapping Technique
Authors: Koç Havva
Published: February 2025

The increasing importance of green finance in the global financial system has led to a surge in related research. However, a comprehensive bibliometric analysis of the green finance literature remains limited. This study aims to analyze the structure of green finance research using VOSviewer. The motivations behind this study include identifying the main themes and trends in green finance research, profiling the leading authors, institutions, and countries contributing to the field, and understanding the relationships between different research clusters within green finance.
A total of 617 publications from 2009 to 2024 were analyzed. The bibliometric analysis results reveal prominent themes and trends in the green finance literature. Additionally, examining the most cited authors, influential institutions, and geographical distribution helps identify key stakeholders in this field. The findings indicate that publications in "Green Finance" are limited, reflecting its status as an emerging area of research. However, as environmental issues escalate, academic interest in this field is expected to grow. This study provides a solid foundation for future green finance research.
Dijital Liderliğin Yenilikçi İş Davranışı Üzerindeki Etkisinde İş Biçimlendirmenin Aracı Rolü
Authors: Karakuş Gülden
Published: February 2025

Teknolojinin değişim hızı ve dijital dönüşüm, çalışanların yenilikçi iş davranışlarını desteklemenin yollarını yeniden şekillendirmektedir. Bu araştırmada dijital liderlik ile yenilikçi iş davranışı arasındaki ilişki ve bu ilişkide iş biçimlendirmenin aracı rolünün araştırılması amaçlanmıştır. İş talepleri-kaynakları modelinden yola çıkılarak, dijital liderliğin çalışanların iş biçimlendirme davranışlarını güçlendirebileceği ve iş biçimlendirmenin aracılığıyla çalışanların yenilikçi iş davranışı gösterme eğilimini artıracağı öngörülmüştür. Araştırmanın verileri farklı sektörlerde özel şirketlerde çalışanlardan toplanmış ve test edilmiştir. Katılımcıların demografik dağılımının belirlenmesi, normal dağılım testi ve korelasyon analizleri SPSS25 programı kullanılarak yürütülmüştür. Ölçeklere ilişkin doğrulayıcı faktör analizi AMOS 24 Programı aracılığıyla test edilirken hipotez testleri için SPSS Process Macro kullanılmıştır. Araştırma bulguları, dijital liderliğin çalışanların yenilikçi iş davranışını olumlu yönde etkilediğini ve iş biçimlendirmenin bu ilişkide tam aracılık rolü olduğunu göstermektedir. Dijital liderlik algısının çalışanların iş biçimlendirme davranışını güçlendirdiğini ve bunun da yenilikçi iş davranışlarını artırdığı tespit edilmiştir. Bu doğrultuda, araştırma bulguları, dijital liderlik, iş biçimlendirme ve yenilikçi iş davranışı arasındaki ilişkilerin, örgütlerin dijital dönüşüm süreçlerinde sürdürülebilir başarıya ulaşmalarında önemli bir rol oynadığını göstermektedir.
Exploring The Twin-Deficit Hypothesis by Considering the Energy Prices in Türkiye: The Evidence from the Rolling Window and the Spectral Causality Analyses
Authors: Güler İlkay
Published: February 2025

Worsening the budget and current account balance has been one of the government’s most urgent issues, especially since the 1980s. Within this context, various studies have been conducted to find the accurate solution and whether there is a connection between the two unpleasant macroeconomic problems. The study aims to address the twin-deficit hypothesis at the full and sub-samples, with different frequencies, by employing the advanced causality test approaches in the case of the Turkish economy by considering energy prices. The Toda-Yamamoto, the Rolling-Window, and Breitung-Candelon Causality analyses are performed on the monthly data spanning from 2009:01 to 2024:08. When examining the evidence on the entire sample, the Ricardian Equivalence hypothesis is verified, and energy prices induce the budget deficit. However, the current account deficit and energy prices affect the budget defict in the short run due to the outcome of the spectral analysis. The Rolling window discloses the causality relationship among the variables at the varied time intervals. The final testament of the study approves the Ricardian Equaliance in the case of Türkiye and rejects the twin-deficit hypothesis. The policy actions are recommended for the policy-makers based on the evidence obtained in the study.
Türkiye’de Phillips Eğrisinin Geçerliliği: MS-VAR Modeli Yaklaşımı
Authors: Durgun Burhan
Published: February 2025

İşsizlik ve enflasyon oranlarından birinin veya ikisinin yüksek olması ekonominin istikrarsız olduğunu göstermektedir. Dolayısıyla bu olguların kontrol altına alınabilmesi için aralarında bir ilişki olup olmadığı ve varsa ilişkinin şeklinin anlaşılması önem arz etmektedir. İşsizlikle enflasyon arasında bir değiş-tokuş olduğunu ileri süren Phillips hipotezi politika yapıcılar tarafından benimsenip uygulama alanı bulmuştur. Ancak literatürdeki çalışmalarda bu hipotezin geçerliliği konusunda bir fikir birliği bulunmamaktadır. Bu çalışmada Türkiye için işsizlik ile enflasyon arasındaki dinamik ilişkiler Markov rejim değişim modeli kullanılarak araştırılmıştır. İki rejimli modelin veri yapısına uygun olduğu belirlenmiş ve bu rejimler düşük istikrarsızlık ve yüksek istikrarsızlık dönemleri olarak adlandırılmıştır. MS-VAR modeli sonuçlarına göre düşük istikrarsızlık döneminde enflasyonla işsizlik arasında pozitif ve zayıf bir ilişki bulunmaktayken yüksek istikrarsızlık döneminde güçlü ve negatif bir ilişki bulunmaktadır. Doğrusal olmayan nedensellik testi işsizlikten enflasyona doğru bir nedensellik ilişkisinin olduğunu göstermiştir. Rejimlere bağlı nedensellik analizinde ise yüksek istikrarsızlık dönemlerinde işsizlikten enflasyona doğru tek yönlü nedensellik ilişkisi tespit edilmiştir. Bu sonuçlar ekonomide yüksek istikrarsızlık dönemlerinde Phillips eğrisinin geçerli olduğunu göstermektedir.
Could Microplasma Ionization and Ultrahigh Mass Resolution Alleviate Chemical Separations for Elemental and Isotopic Analysis?
Authors: Marcus R. Kenneth
Published: February 2025

At the extremes, all analytical spectrometric measurements are limited by the resolution of the spectrometer system. Spectral overlaps, isobars in the case of mass spectrometry, can lead to the implementation of complex and time-consuming chemical separations to alleviate those interferences. In the area of elemental/isotopic mass spectrometry, use of sector-field instruments can provide a mass resolution of ~10,000, but still necessitate chemical separations. Described here is the coupling of the liquid sampling-atmospheric pressure glow discharge (LS-APGD) microplasma to ultra-high resolution Orbitrap mass analyzer systems to yield mass resolution values ranging from 70k to 1M. Resolution of this order, with commensurate improvements in precision and accuracy, holds the promise to affect elemental/isotopic determinations without the need for chemical separations.
ПОВРЕЖДЕНИЕ ЛИСТЬЕВ ДРЕВЕСНЫХ РАСТЕНИЙ ВРЕДИТЕЛЯМИ И БОЛЕЗНЯМИ В ГОРОДАХ МОСКВА И ДАМАСК В УСЛОВИЯХ АВТОТРАНСПОРТНОГО ЗАГРЯЗНЕНИЯ
Authors: Дауара А. , Зубкова В.М. , Еременко К.В.
Published: February 2025

Проанализирована распространенность основных болезней и вредителей древесных растений, выявлены их видовые особенности на территориях, расположенных вдоль оживленных автомагистралей городов Москва и Дамаск.
ВЛИЯНИЕ СЕРОВОДОРОДА НА ПАРАМЕТРЫ ФЛУОРЕСЦЕНЦИИ ХЛОРОФИЛЛА ЗЕЛЕНЫХ ВОДОРОСЛЕЙ
Authors: Яковлева О.В. , Орлова В.С. , Братковская Л.Б. , Алексеев А.А. , Маторин Д.Н. , Краснова Е.Д.
Published: February 2025

С использованием флуоресцентных методов изучено токсическое действие сероводорода на зеленые микроводоросли.
ЗАКОНОМЕРНОСТИ ГЕОЛОГИЧЕСКОГО СТРОЕНИЯ ЗЕМЛИ (С ПОЗИЦИИ СИСТЕМНО-СТРУКТУРНОГО ПОДХОДА)
Authors: Казанкова Э.Р. , Корнилова Н.В.
Published: February 2025

Рассмотрены новые представления о пространственно-временном размещении и иерархии многоуровневых геологических структур. Показана системно-структурная организация и причинно-следственные связи процессов и явлений в геолого-геофизической среде.
ОСОБЕННОСТИ ПРОСТРАНСТВЕННО-ВРЕМЕННОГО РАСПРЕДЕЛЕНИЯ ФОТОСИНТЕТИЧЕСКИ АКТИВНОЙ РАДИАЦИИ В ИРАКЕ
Authors: Махмуд А.М. , Болотов А.Г.
Published: February 2025

Исследовано пространственно-временное распределение фотосинтетически активной радиации (ФАР) и зависимость между облачностью и ФАР и индексом листовой поверхности (LAI) для территории Республики Ирак за период 2000-2022 гг. Показано, что интенсивность ФАР увеличивается по мере продвижения к югу Ирака в зимний сезон, в то время как осенью происходит инверсия этих значений. Существует положительная корреляция между фотосинтетически активной радиацией и индексом листовой поверхности, который увеличивается на севере и в юго-восточном регионе Ирака.
ФАКТОР ПАРАЗИТИЧЕСКОГО ПОРАЖЕНИЯ КУЛЬТИВИРУЕМЫХ РАСТЕНИЙ В СОВРЕМЕННЫХ УСЛОВИЯХ УРБАНОСРЕДЫ
Authors: Кирюнин И.И. , Ларионов М.В. , Абумуслимов А.С. , Володькин А.А. , Левкина Г.В.
Published: February 2025

Паразиты представляют один из приоритетных биотических факторов снижения устойчивости и утраты хозяйственных качеств у культивируемых в городских и пригородных условиях древесных растений. В данной работе рассказывается о стекляннице смородиновой паразитирующей на смородине черной и на некоторых других кустарниках. Это один из самых распространённых и вредных насекомых, борьба с которым требует комплексного подхода. В условиях агрессивного действия техногенных факторов пригородных и особенно городских ландшафтов лимитирующий фактор паразитического поражения культивируемых растений усиливается.
ЭКОЛОГИЧЕСКАЯ ПРОБЛЕМА ВЛИЯНИЯ МИКРОПЛАСТИКА НА СОСТОЯНИЕ РАСТЕНИЙ, ОКРУЖАЮЩУЮ СРЕДУ И ЗДОРОВЬЕ ЧЕЛОВЕКА
Authors: Ларионов М.В. , Сайдумов М.С. , Ларионов Н.В. , Володькин А.А. , Шилова Н.А. , Головин А.А. , Левкина Г.В. , Косёнков А.В. , Бондаренко С.П.
Published: February 2025

Актуализируется эколого-гигиеническая проблема загрязнения окружающей среды микропластиком. Это совокупное наименование группы современных поллютантов, загрязняющих разные среды. Микрочастицы пластмасс представляют реальную опасность для биологических объектов. Микропластик снижает жизнедеятельность растений, угнетающе действует на метаболические процессы. Еще недостаточно изучено воздействие микропластика на человеческий организм. Из-за наличия микрочастиц некоторых синтетических полимеров могут инициироваться многие болезненные состояния у человека. Необходимо расширение перечня контролируемых поллютантов, включая микрочастицы пластмасс. Требуется модернизация подходов к мониторингу и оценке загрязнения абиотических и биотических объектов окружающей среды.
Test Organisms Sodium Arsenit Sensitivity in the Environment Quality Multicomponent Biotesting System
Authors: Chupis V.N. , Luschay E.A. , Larin I.N. , Zagrekov A.A. , Il’ina E.V. , Ivanov D.E.
Published: February 2025

The results of an estimation of influence of natrium arsenite in solutions of various concentration on intensity of bioluminocity of bacteria, mortality of daphnia and ceriodaphnia, chemotaxic reaction of infusoria, impellent activity of daphnia, growth of chlorella and scenedesmus alga chlorophyll fluorescence are given. The greatest sensitivity to natrium arsenite is found for daphnia and ceriodaphnia. The conclusion about expediency of use lowest crayfishes in ecological monitoring of the enterprises on natrium arsenite processing is made.
Oil-Polluted Soils Complex Biotesting
Authors: Kireeva N.A. , Kabirov T.R. , Dubovik I.E.
Published: February 2025

Investigation was held to maintain a complex biotest system for indication of oil polluted soils toxicity levels for different groups of organisms. Soil enzymes, plants, soil animals, bacteria and algae were tested for there co-operative response for oil pollution. A pattern was observered, allowing approximate evaluation of oil polluted soil condition based on this biotests.
Plants Adaptive Reactions to the Aluminium Acidity and Toxicity Factors
Authors: Shirokikh I.G.
Published: February 2025

In laboratory experiments variety reaction of winter rye and barley shoots on the factors of acidity and toxicity of aluminum on parameters of growth and root excretion was estimated . It is shown, that distinctions in strategy of adaptation to aluminum - acidic stress of separate genotype can be appreciated on a ratio of production and environmental components in structure of the response of plats on stress.
Scientitic-methodological grounds of Complex Ecological Environment Monitoring in the Vicinity of Chemical Weapon Storage and Destruction Objects
Authors: Ashikhmina T.Y.
Published: February 2025

Scientific-methodological grounds of complex ecological monitoring organization within the objects of chemical weapon storage and destruction are presented. The results of environmental ecological monitoring in the vicinity of the object «Maradikovsky» in the Kirov region are shown.
Ecological monitoring of objects of destruction of a chemical weapon experience of creation and prospect for the development
Authors: Chupis V.P.
Published: February 2025

The article deals with the realization of the systems of state ecological control and ecological monitoring in the three working chemical weapon destruction objects in Russia. Their main basic principles and structural-functional schemes are set. The grounds of the optimal spe+cial structure of the monitoring system net and the regulations of its functioning are presented.
Successful input and exploitation of three new objects of destruction of a chemical weapon endorsement by Russia of the obligations of the Convention
Authors: Kapashin V.P.
Published: February 2025

The article deals with creation of new chemical weapon destruction objects in Russia and with fulfillment of the Convention obligations.
The Structure and Principles of Building up Manystep Safety System of the Critically Important and Potentially Dangerous Object (Chemically Dangerous Object,Chemical Weapon Storage and Destruction Object)
Authors: Gabrichidze T.G. , Ynnikov I.M.
Published: February 2025

The article deals with the main principles of the integrated system of safety provision in potentially dangerous objects. This system is included in the structure of the regional sub+division of the united state system of emergency situations prevention and liquidation. Technological and administrative aspects of the system functioning are investigated in detail. Special attention is paid to developing ecological monitoring system that includes traditional methodic of chemical+analytical control and up+to+date eco+analytical methods such as distance and biological methods of monitoring.
On the System of Ecological Observation of Environmental State in the Zone of Chemical Weapon Storage and Destruction Object in Shchuchansky district of Kurgan region
Authors: Shingarenko T.A.
Published: February 2025

The realization of the model of economic monitoring within the zone of the chemical weapon destruction object in the Shchuchansky district is represented. The worked out model serves as a basis for evaluating and prognosis of the state of natural ecological systems in conditions of multiple technogenic impact. The system of sampling provides sufficient and reliable data of all the priority poison substances.
Forms and Methods of Informing the Population, that Lives within the Territory of the Protection Works on the Object «Maradikovsky» in Orichi District ofKirov Region of Chemical Weapon Destruction
Authors: Filyov P.V.
Published: February 2025

The results of the work of the Mirny information+analytical center of Russia Green Cross and the public relation group of the object 1205 «Maradikovsky» that deal with informing the population of safe functioning of objects for storage and destruction the chemical weapon are generalized in the article.
Single molecule peptide synthesis without any side-chain protection using a nanopore and a sub-nanometer positioning system
Authors: Sampath G
Published: February 2025

Peptide synthesis without side-chain protection is proposed at the single molecule level. A peptide is synthesized C-to-N or N-to-C as an extension to a homopeptide header with one end bound to a fixed surface and the other free and enclosed by a nanopore. The surface is mounted on a platform that can be moved with 0.1-0.15 nm precision; the pore acts like a ribosome tunnel to protect amino acid (AA) side-chains from unwanted couplings and also prevents aggregation and cyclization. Synthesis occurs in cycles with the following steps: a coupling agent attaches an end-protected AA to the terminal residue of the growing header at the end of the pore; completion of coupling is detected optically; coupling agent, protector, and excess AAs are washed out; the platform is retracted by 3.5 Å; the newly added AA is deprotected and the protector washed out. On completion of synthesis the platform is moved toward the pore by the added peptide’s length, the peptide is separated from the header. A combination of electrical potential and hydraulic pressure keeps the peptide fully stretched at all times. The nanopore plays a secondary role, no measurements are made on it. Parallel synthesis can be done with an array of headers and an array of nanopores, capacities of up to a femtomole may be possible. Higher capacities may be possible if header-peptides are passed through wider pores in loose bundles. In principle there is no limit to the length of the peptide that can be synthesized. With no side-chain protection, minimal reagent amounts, reduced washing, and almost no post-synthesis cleanup, the method has a potentially high level of greenness.
A new perspective on aqueous electrolyte solutions
Authors: Schwaab Gerhard , Pezzotti Simone
Published: February 2025

Aqueous electrolyte solutions are central to many natural phenomena and industrial applications leading to continuous development of increasingly complex analytical models. These are based on an atomistic description of ion-ion electrostatic interactions combined with mean-field approaches for the dielectric response of water. Despite many achievements, these concepts fail to quantitatively describe situations where ion-ion correlation and specific solvation become relevant, such as for concentrated electrolyte solutions. Here, we propose a change of perspective, by introducing a statistical, coarse-grained view to describe the average thermodynamic properties of aqueous electrolyte solutions. This approach bypasses the need to define ion-pairs or ion-complexes and does not require any prior knowledge on specific solvation. We base our concept on separating the solution into a spherical observation droplet whose size and average composition are uniquely determined by the solution parameters, and its environment consisting of the remaining solution. This allows us to express the droplet-environment interaction in terms of a generalized multipole expansion, i.e. in a convenient, additive way. We applied this approach to 135 electrolytes including some notoriously complex electrolytes, such as LiCl or ZnCl$_2$ over the full solubility range. This paves the road toward understanding super-saturated and water-in-salt solutions and electrolyte nucleation.
The School Completion Programme revisited
Authors: Smyth Emer , Hingre Garance , Darmody Merike
Published: February 2025

The School Completion Programme was established in 2002 to provide support for children and young people at risk of early school leaving and is part of a suite of supports offered through the Delivering Equality of Opportunity in Schools (DEIS)1 programme. The programme is run by Tusla Education Support Service (TESS) with oversight from the Department of Education. The programme is organised into 121 projects managed by a coordinator and overseen by a Local Management Committee (LMC). Each project covers a number of primary and post-primary schools. The programme currently covers 783 schools that have a total population of over 250,000 students. The three core outcomes of the programme are improved attendance, improved participation (engagement in learning and other school activities) and improved retention among children and young people, with improved participation seen as leading to increases in attendance and retention levels. To achieve these objectives, there are three levels of intervention: the target group, children and young people identified with the greatest need to whom staff provide more intensive support; brief interventions, designed to address a temporary crisis; and universal interventions that provide whole-class support, for example through a life skills programme. The strands of support are divided between in-school supports, supports around the school day (before or after school, or at lunchtime), holiday provision and supports for young people who are out of school (because of school avoidance, suspension/expulsion, or early school leaving).

A review of the programme conducted by the ESRI in 2015 highlighted its value in providing flexible and needs-based supports to vulnerable children and young people. However, the review highlighted a number of challenges, including project governance, variation in the size of projects and the supports provided, and the impact of austerity-related funding decreases. In the intervening period, there have been a number of changes to the programme, including an increase in funding, the introduction of a new intake framework to refer students, a greater emphasis on evidence-based programmes (such as Decider Life Skills and Working Things Out), a roll-out of continuous professional development for staff and webinars for LMC members. There have also been considerable changes in the broader societal context, with the impact of the pandemic on wellbeing leading to marked increases in school non-attendance. This report draws on a survey of SCP coordinators, detailed case studies of six projects, and a consultation event conducted with SCP coordinators and project workers. This rich information is used to examine the operation of SCP in this changed landscape and highlight the implications for future development of the programme.
Nonlinear boundary value problems for degenerate differential-algebraic systems in the noncritical case
Authors: Chuiko Sergey , Nesmelova Olga , Chuiko Olena
Published: February 2025

We have obtained the conditions of existence and a scheme for constructing solutions of a weakly nonlinear boundary value problem for a degenerate differential-algebraic system in the noncritical case. The boundary condition is determined by a weakly nonlinear vector functional. The linear part of the problem is a linear boundary value problem for a degenerate differential-algebraic system.
Linear differential-algebraic boundary value problems have been studied in monographs by S. Campbell, J.R. Magnus, A.M. Samoilenko and V.P. Yakovets. In the works of A.M. Samoilenko and O.A. Boichuk, using the central canonical form, the necessary and sufficient conditions for the existence of solutions of nonlinear differential-algebraic boundary value problems were obtained.
We have obtained necessary and sufficient conditions for the existence of solutions of nonlinear differential-algebraic systems without using the central canonical form, which allows us to study the solvability of differential-algebraic boundary value problems that depend on arbitrary continuous functions. This approach significantly varies the classification of nonlinear differential-algebraic boundary value problems in critical and noncritical cases.

Our formulation of the weakly nonlinear differential-algebraic boundary value problem generalises the boundary value problems studied in the works of Yu.O. Mitropolsky, A.M. Samoilenko, and O.A. Boichuk. The case when a differential-algebraic system is not solvable with respect to the derivative is considered, and substitutions of the unknown are proposed. It leads the original system to a nonlinear differential-algebraic system solvable with respect to the derivative.
Finally, we present an example of a nonlinear differential-algebraic antiperiodic boundary value problem for a Riccati-type equation, which demonstrates the constructiveness of the obtained necessary and sufficient conditions for the existence of solutions of nonlinear differential-algebraic systems.
The obtained results can be transferred to the problems of finding conditions for the existence and schemes for constructing solutions of nonlinear degenerate differential-algebraic boundary value problems in critical cases, as well as to the problems of finding conditions for the stability of such solutions.
Development of a Head Gesture-Controlled Robot Using an Accelerometer Sensor
Authors: Ore-Ofe Ajayi , Umar Abubakar , Ibrahim Ibrahim , Abiola Ajikanle Abdulbasit , Olugbenga Lawal Abdulwahab
Published: February 2025

In this research, a head gesture-controlled robot was designed and developed to assist individuals with disabilities in performing tasks by translating head movements into robot commands. Using an accelerometer sensor embedded in a headgear device, the system interprets specific gestures—such as forward nods for forward movement, backward nods for reversing, and lateral tilts for turning left or right—into corresponding robotic actions. The design involved constructing a mechanical framework for the robot, assembling the headgear, and integrating both with Arduino-based programming to ensure accurate and responsive movements. Testing was conducted in a controlled setting, where the robot consistently followed head gestures with a high degree of accuracy, showing rapid response times to user inputs. Quantitative results demonstrated the system’s reliability, with over 95% accuracy in gesture recognition and minimal latency. This innovative system underscores the potential of head gesture-controlled robotics in assistive technology, offering an affordable, user-friendly solution to enhance mobility and autonomy for individuals with limited physical capabilities
Human Recombinant Arginase I (Co)-PEG5000 [HuArgI (Co)-PEG5000]-Induced Arginine Depletion Leads to Autophagy-Dependent Cell Death in Prostate Cancer Cells
Authors:   ,   Lebanese American University -- Chouran Beirut, Chehab Lemir Malek
Published: February 2025

Prostate cancer ranks as the second most frequently diagnosed malignancy in men and represents the fifth highest cause of cancer-related mortality globally. While conventional treatments like surgery and radiotherapy reliably cure patients, advanced and recurrent prostate cancer often necessitates alternative therapies. Emerging treatments targeting cancer cell metabolism show promise, particularly those focusing on amino acid deprivation, such as arginine, specifically in tumor types that downregulate argininosuccinate synthetase 1 (ASS1) and ornithine transcarbamylase (OTC) expression—urea cycle enzymes important for the synthesis of arginine—rendering those tumor types auxotrophic for arginine. In this study, we report the use of a pegylated recombinant human arginase I coupled to cobalt, [HuArgI (Co)-PEG5000], to induce arginine depletion in two prostate cancer cell lines: DU-145 and PC-3. Our objective was to investigate the cytotoxic effects of the [HuArgI (Co)-PEG5000]-induced arginine deprivation, characterize the extent of arginine auxotrophy in these cell lines, and elucidate the underlying mechanisms of cell death induced by arginine deprivation. This was tested through a series of proliferation inhibition assays, analysis of ASS1 and OTC expression on flow cytometry and western blots, as well as examining the type of cell death through Annexin V/PI staining. Autophagy activation was assessed through a CYTO-ID autophagosome detection kit on flow cytometry and the impact of autophagy on cell cytotoxicity was investigated after its inhibition through cytotoxicity assays. Our findings reveal that [HuArgI (Co)-PEG5000]-induced arginine deprivation exhibited cytotoxicity in both cell lines, with the earliest effect observed at 24 hours post-treatment and maximal cell death at 120 hours post-treatment. The addition of excess exogenous L-citrulline rescued cell viability in cells, suggesting partial arginine auxotrophy. Analysis of ASS1 and OTC expression confirms partial arginine auxotrophy and suggests a possible feedback loop through which expression patterns change depending on the availability of extracellular arginine and L-citrulline. Analysis of cell death mechanisms revealed negative Annexin V staining, indicating a possible non-apoptotic pathway. Furthermore, autophagy activation was evident following arginine deprivation and the inhibition of this autophagy using chloroquine reduced the cytotoxic effects, underscoring the role of autophagy in cell death induced by arginine deprivation. Our results, in conclusion, demonstrate the potential of arginine deprivation by [HuArgI (Co)-PEG5000] as a potent and selective treatment for prostate cancer, and highlight the involvement of autophagy in this process.
Human Recombinant Arginase I (Co)-PEG5000-Induced Arginine Depletion of Breast Cancer Cell Lines Causes Autophagy Mediated Cell Death
Authors:   ,   Lebanese American University -- Chouran Beirut, Alayan Moustapha
Published: February 2025

In this study, we showed for the first time that arginine deprivation induced by a recombinant human arginase drug induces selective cytotoxicity mediated by autophagy in distinct human breast cancer cell lines. Breast cancer remains the most prevalent, life-threatening cancer in women, posing a dire global burden. As of 2022, 2.3 million women were diagnosed with breast cancer, 670,000 of which died. New selective, targeted therapeutics have been on the rise in the past decade. Arginine-depleting enzymes, such as [HuArgI(Co)-PEG5000], have been showing promising in vitro results in the treatment of auxotrophic Acute Myeloid Leukemia (AML), glioblastoma, pancreatic, and ovarian cancer. This study’s major aim is to examine the potency of the pegylated form of Arginase I enzyme, [HuArgI(Co)-PEG5000], in the selective treatment of three breast cancer cell lines: MDA-MB-231, MCF-7, and UACC-2087. Our cytotoxicity assay results show that all three cell lines were sensitive to the human arginase drug up to 120 hrs post-treatment. Addition of excess amounts of L-citrulline, a precursor of arginine, led to rescue of all three cell lines indicating that these cells do express ASS1 and are, therefore, partially auxotrophic for arginine. Flow cytometry results validated this as all three cell lines were positive for ASS1 expression. In attempt to investigate autophagy activation, both CytoID flow cytometry staining and western blots of LC3-I/LC3-II were conducted. All three cell lines showed sustained activation of autophagy lasting up to 120 hours following arginine deprivation. The impact of autophagy on cell cytotoxicity of [HuArgI(Co)-PEG5000]-induced arginine deprivation was then assessed through autophagy inhibition using the downstream autophagy inhibitor chloroquine (CQ). Inhibition of autophagy decreased sensitivity to arginase-induced cytotoxicity in all cell lines, and hence reversed cell death. This implies that arginase-induced cell death is autophagy-mediated. Overall, these findings suggest that [HuArgI(Co)-PEG5000] is a potent therapeutic agent for breast cancer, leveraging the autophagy pathway to selectively induce cytotoxicity in ASS1-expressing breast cancer cells. Further investigation into this therapeutic strategy could pave the way for new, effective treatments for breast cancer.
Factores de Riesgo Psicosocial asociados al personal administrativo de un hospital General en Ecuador
Authors: Olmedo Vera Jorge Hernán , Tello Moreira José Antonio , Cantos Santana Erick Manuel , Murillo Moreira Klever Xavier
Published: February 2025

Objetivo: Identificar, valorar y cuantificar los factores de riesgo psicosocial, a los que se ve expuesto el personal que labora en el área administrativa un hospital General mediante la aplicación de cuestionario de riesgo psicosocial del Ministerio del trabajo de la Republica del Ecuador. Métodos: Esta investigación fue de carácter cualitativo, se aplicó un diseño observacional prospectivo, descriptivo, de corte trasversal, realizado en el personal administrativo de un Hospital General, criterios de inclusión deben existir relación laboral con el hospital, la población debe laborar en el área administrativa, dicha población debe recibir capacitación previa sobre riesgo psicosocial, el total de la población a estudiar son 28 trabajadores. Resultados: Se evidencia que la edad de la población oscila desde los 18 a 55 años con un promedio de entre 35 a 43 años, reflejando un porcentaje mayor de hombres con nivel de instrucción alto, con una antigüedad laboral entre los 3 a 10 años en la institución. Se demuestra que el 75% de la población mantiene una escala de riesgo psicosocial bajo, 31% mantiene un riesgo medio, y el 4% mantiene riesgo alto. Conclusión: Entre los factores de riesgo psicosocial elevados asociados al personal administrativo de un hospital General el acoso laboral es el más significativo con un 18% de incidencia, seguido de acoso discriminatorio, falta de liderazgo, recuperación que presentan 11% cada uno. Los resultados obtenidos, permiten la oportunidad de crear, socializar, y aplicar programas integrales de prevención de riesgo psicosocial en el trabajo.
Structural Assessment and Rehabilitation of an Existing Hydraulic Masonry Structure Supporting Railway
Authors: Makhlouf Aly A. , Omar M. , Emarah Dina A.
Published: February 2025

Old hydraulic masonry structures are essential components of global road and rail infrastructures. Over decades of operation, these structures have experienced inevitable deterioration, necessitating evaluations of their structural conditions through comprehensive assessment and rehabilitation programs to ensure compliance with contemporary safety standards. This study focuses on a specific regulator as a case example to implement a rehabilitation strategy aimed at restoring its structural integrity after 190 years of continuous service. From 2015 to 2021, an extensive program was conducted to assess the condition of the construction materials. This program included mechanical and physical testing, as well as Finite Element Analysis (FEA), to identify areas of high stress and to analyze the distribution of stress throughout the structure. The findings revealed that the structure fails to meet current Egyptian standards, thereby underscoring the critical need for a strengthening program. Subsequently, a rehabilitation intervention was developed, which involved reinforcing the intrados of the arches and piers with a slender reinforced concrete jacket. These reinforcements were integrated with the existing structure using steel shear bar connectors. Following the rehabilitation, a re-evaluation of the analysis of the modified structure using FEA software confirmed compliance with Egyptian specifications. The proposed rehabilitation strategy offers a viable solution to the challenges associated with the examined masonry arch bridge. Doi: 10.28991/CEJ-2025-011-02-012 Full Text: PDF
Smart Roundabout Coordination Systems for Sustainable Urban Mobility
Authors: Halawani Ahmed T. M.
Published: February 2025

Traffic signal coordination control is a smart approach used in urban networks to relieve the congestion by increasing corridor throughput and minimizing overall traffic delay. Previous studies have investigated various signal coordination challenges; however, integrating roundabouts into a coordinated signalized corridor without compromising their operational distinctiveness remains underexplored. This study introduces an adaptive traffic signal offset strategy incorporating a platoon compaction factor to address the dispersion effects caused by roundabouts, ensuring the preservation of platoon movement along the coordinated corridor. The method was evaluated using the PTV VISSIM micro-simulation software. The results show improvements in sustainability indicators at roundabouts, with average corridor-level delays minimized by 17%, delays associated with vehicle stops reduced by 28%, fuel consumption reduced by 16%, and emissions reduced by 9% and 16% for NOₓ and CO₂, respectively. These improvements were statistically significant, affirming the robustness of the proposed method. The findings underscore the potential benefits of implementing this framework in real-world traffic scenarios, contributing to making urban transportation systems more efficient and sustainable. Doi: 10.28991/CEJ-2025-011-02-013 Full Text: PDF
A Novel Exact Solution of Longshore Current and Its Application on Permeable Groin
Authors: Umar Hasdinar , Assidiq Fuad M. , Triatmadja Radianta , Baeda Achmad Y.
Published: February 2025

One major environmental problem exacerbated by longshore currents is beach erosion. Groins are a common defense tactic built perpendicular to the shore. However, conventional impermeable groins promote downstream erosion and disrupt sediment movement. Permeable groins provide a more environmentally friendly option, allowing some sediment to flow through. This study examines the effects of permeable groins on longshore currents. Permeable groins are not included in currently used longshore current equations. This study fills this gap by creating a new longshore current velocity equation considering permeable groins. The longshore current equation with the groin was developed based on the momentum equation in the longshore direction without the influence of lateral mixing and the assumption that base friction will rise due to the groin. Therefore, it was determined that the base shear stress after the groin was equal to the base shear stress plus the drag caused by the groin. The result shows that the longshore current equation through the groin is a function of the breaking wave parameter and the resistance parameter owing to the groin. Longshore current velocities with and without permeable groins of different densities were measured in wave basins. We collected information on groin characteristics, current velocities, and breaking wave heights. This investigation validates the shortcomings of the current equations. Doi: 10.28991/CEJ-2025-011-02-07 Full Text: PDF
Understanding Continuance Intention of Merchants as End User in Online Food Delivery After COVID-19
Authors: Yasirandi Rahmat , Thanasopon Bundit
Published: February 2025

This study explores the continuance intention of merchants in using Online Food Delivery (OFD) services post-pandemic, employing an extended Expectation-Confirmation Model (ECM). While existing research on OFD predominantly examines food consumers, this study focuses on the merchant side and investigates how confirmation, perceived usefulness, satisfaction, perceived risk, and perceived critical mass influence their continuance intention. Using Structural Equation Modeling (SEM) on data collected from 378 Indonesian merchants, the findings highlight several critical factors. Perceived critical mass fosters platform adoption by creating a sense of widespread utility, while perceived risk indirectly affects continuance intention through its impact on satisfaction, emphasizing the need to address merchants’ concerns. This research enhances the understanding of merchant behavior in the OFD ecosystem by incorporating context-specific factors that influence their decisions. The findings offer practical recommendations for OFD providers to improve system reliability, mitigate perceived risks, and foster a robust user community to ensure sustained engagement. Future studies could build on these insights by investigating similar dynamics in different regions or by including other stakeholders, such as delivery drivers, to provide a broader understanding of the OFD ecosystem. Doi: 10.28991/HIJ-2025-06-01-012 Full Text: PDF
Smart Data Placement Strategy in Heterogeneous Hadoop
Authors: Bakni Nour-Eddine , Assayad Ismail
Published: February 2025

Big Data platforms are becoming increasingly essential these days, given the volume of data generated every moment by millions of people around the world. The Hadoop framework is a solution that allows storing and processing these large amounts of data in parallel on a cluster of machines. The default data placement strategy adopted by the Hadoop Distributed File System (HDFS), initially designed for a homogeneous cluster where all machines are considered identical, relies on distributing data to nodes based only on their disk space availability. Implementing this strategy in a heterogeneous environment, where nodes have varying computing or disk storage capacities, may result in performance degradation. In this paper, we propose a smart data placement strategy (SDPS) in heterogeneous Hadoop clusters that aims to place high-access data on high-performance nodes. It takes cluster heterogeneity into account when distributing data by first dividing nodes into groups based on their performance levels using a clustering algorithm and then allocating data blocks to appropriate nodes based on their hotness. SDPS also allows dynamically specifying the replication factor of data blocks to reduce storage space waste while maintaining data availability. Experimental results show that SDPS is more efficient in a heterogeneous environment compared with the default data placement policy of HDFS, and it improves MapReduce data processing, data locality, and storage efficiency. Doi: 10.28991/HIJ-2025-06-01-03 Full Text: PDF