bluuebunny/crossref_metadata_2025 huggingface dataset:
Духовність та професійне становлення майбутнього педагога-організатора закладу загальної середньої освіти: інтеграція цінностей в освітній процес
Authors: Щедріна Марина
Published: April 2024

У статті аналізується сучасна освітня ситуація, що характеризується динамізмом змін, зростанням інформаційних потоків та потребою у формуванні особистості з чіткими ціннісними орієнтирами. Виокремлюються ключові духовні цінності (людяність, відповідальність, справедливість, чесність, патріотизм, повага до інших культур та традицій), що мають бути притаманні педагогу-організатору. Досліджується вплив духовності на професійний розвиток педагога-організатора: формування особистісного світогляду, гуманістичної спрямованості, емпатичних здібностей, здатності до саморозвитку та самовдосконалення. Розглядаються інструменти, необхідні для інтеграції духовних цінностей в освітній процес: виховні години, тренінги, семінари, волонтерські проєкти, духовна література та мистецтво. У статті наголошується на ролі духовних цінностей та патріотизму в забезпеченні духовної безпеки особистості, особливо в умовах сучасних викликів. Розкривається значення міжкультурної освіти та громадянського виховання як факторів формування толерантної, відповідальної та активної особистості. Пропонуються рекомендації педагогам-організаторам щодо використання різноманітних методичних матеріалів та програм із метою підтримки духовності та громадянського виховання в шкільному середовищі.
Документування фольклорної інформації: мережеві ресурси для збереження культурної спадщини
Authors: Столярчук Богдан , Остапчук-Будз Марія
Published: April 2024

У статті акцентовано увагу на важливості збереження культурної спадщини в умовах глобалізації, релігійних утисків та військових конфліктів. Автори вказують на значні втрати культурних цінностей в Україні внаслідок війни, зокрема знищення та пошкодження 835 об’єктів культурної спадщини. Основна увага приділяється фольклору як центральній складовій нематеріальної культурної спадщини. У статті також розглядаються міжнародні зусилля щодо охорони усної народної творчості, зокрема прийняття відповідних законів та конвенцій.

Автори аналізують проблему доступу до фольклорних матеріалів в мережі «Інтернет» та важливість їхнього документування. Підкреслено, що електронна форма фіксації фольклору, зокрема мережеві ресурси, забезпечує неабиякі можливості для збереження та забезпечення доступу до української фольклорної спадщини. Однак необхідний системний підхід до архівування фольклору, оскільки багато цінних матеріалів знаходяться під загрозою знищення. «Електронний архів українського фольклору» може стати основою для такої системи, забезпечуючи ефективне збереження, пошук та популяризацію фольклорних надбань.

Загалом у статті підкреслюється необхідність збереження та розвитку культурної різноманітності з метою передачі наступним поколінням шляхом створення мережевих ресурсів фольклорної інформації.
Isolation of flavonoids from Tagetes patula(French Marigold) flowers: Cytotoxic and oxidant activity in human cervical carcinoma cells
Authors:   Universidade Estadual de Maringa, Zardeto Giuliana , Krzyzaniak Leticia Maria ,   Universidade Estadual de Maringa, Palazzo de Mello Joao Carlos ,   Universidade Estadual de Maringa, Ueda-Nakamura Tania ,   Universidade Estadual de Maringa, Dias-Filho Benedito Prado ,   Universidade Estadual de Maringa, Silva Sueli de Oliveira ,   Universidade Estadual de Maringa, Nakamura Celso Vataru ,   Universidade Estadual de Maringa
Published: April 2024

Tagetes patula, known as French Marigold, belongs to the family Asteraceae. Human papillomavirus infection is considered one of the causes of cervical cancer. This study assessedthe cytotoxic activity and intracellular oxidative capacity of compounds isolated from extract of T. patulaflowers as anti-cancer cervical agents. Fraction F6 of n-butanol extract was subjected to column chromatography and HPLC-ESI-MS. The isolated compounds of T. patulawere used to examine cytotoxic activity and the production of total reactive oxygen species in SiHa and HeLa cells; the cells were also characterized using scanning electron microscopy. Patulitrin was cytotoxic to SiHa and HeLa cells. An increase in ROS production was observed at different times of treatment of cells with patuletin and patulitrin. Scanning electron microscopy showed morphological changes in SiHa and HeLa cells. Thus, compounds isolated from T. patulahave great treatment potential against cervical cancer.
Opportunities for using telemedicine based on the COVID-19 pandemic
Authors: Malykhin F. T.
Published: April 2024

Relevance. The SARS-CoV-2 (COVID-19) pandemic highlighted the use of telemedicine in healthcare delivery during a public health emergency to remotely assess and provide care to patients already infected with the coronavirus or those fearing exposure to COVID-19 through face-to-face contact.

Objective. Explore the response of the world’s health systems and their medical institutions to the situation caused by the COVID-19 pandemic using telemedicine and its practical application and contribution to health care in the era of the COVID-19 pandemic.

Methods. A search analysis of published literature data was conducted using the English-language database of medical and biological publications PubMed. The most up-to-date information is obtained from relevant websites.

Results. The concept of telemedicine, its legislative framework, and current trends in its practical application are discussed. It has been confirmed that there has been a sharp increase in the use of telemedicine and mobile applications in response to the COVID-19 pandemic and the need for infection control. Assessed healthcare provider, health insurance, and pharmacy policy reforms in several countries to integrate telemedicine into practice in response to the COVID-19 pandemic. It has been established that the expansion of the use of telemedicine in the COVID-19 era has confronted society as a whole with the need to solve some practical problems that impede progress in this area. The recommendations of professional medical organizations regarding telemedicine during the COVID-19 pandemic were analyzed, and attempts were made to solve the problems of advanced telemedicine practice.

Conclusion. The use of telemedicine is undeniably effective in promoting social distancing and isolation/quarantine of patients, which is a proven means of strengthening the public health position in countering the spread of coronavirus. The need for social distancing has made telemedicine a critical factor in the fight against the pandemic spread of COVID-19.
Learning Through Play at School Ukraine: Final Research Report
Authors: Parker Rachel , Berry Amy , Picker Kellie , Jeffries David , Anderson Prue , Zabolotna Oksana
Published: April 2024

The Learning Through Play (LTP) at School Research Study Ukraine was a four-year intervention study funded by the LEGO Foundation and implemented by the Australian Council for Educational Research (ACER) and the Ukrainian Educational Research Association (UERA). The intervention was a two-year professional learning program that blended online, and face-to-face learning called the Teacher Innovative Play Program (TIPP). The TIPP was designed based on documented evidence that reports that teachers need opportunities to experiment and reflect to change practice. The study was guided by three research questions which were revised following the full-scale invasion of Ukraine by Russian armed forces on February 24, 2022. The revised questions were as follows: 1. What are the barriers and enablers that limit and/or support effective implementation of LTP in intervention school classrooms? 2. How do teachers in intervention schools implement LTP and adjust their classroom practices to promote learners’ literacy and social and emotional development? 3. How do children’s literacy and social emotional skills compare between testing time points including prior to and during the invasion of Ukraine by Russian armed forces?
DEVELOPMENT OF THINKING OF SECOND-GRADERS IN MATHEMATICS LESSONS IN THE PROCESS OF MASTERING THE LOGICAL METHOD OF CLASSIFICATION
Authors:   Gulistan State University, Faculty of Psychology and Social Sciences, 3rd year student, Uzbekistan, kizi Khabibullayeva Shoira Farhod
Published: April 2024

The article is devoted to the study of the thinking of younger schoolchildren and one of the types of universal educational actions -logical actions, which are the basis of the ability to learn. The formation of a logical classification technique for second graders in mathematics lessons causes difficulties for the teacher. The problem of the study was the study of the specifics of the development of thinking of second graders in mathematics lessons in the process of mastering the classification technique. The purpose of the study is to identify the pedagogical conditions for the development of second-graders' thinking in mathematics lessons in the process of mastering the logical classification technique. The article describes the process of developing the thinkingof second graders in mathematics lessons by means of multi-level tasks.
CROSS-SECTIONAL STUDY OF BLOOD PRESSURE AND TSH VALUES IN A POPULATION WITH CASSAVA AS STAPLE FOOD
Authors:   Department of Physiology, Government Medical College, Ernakulam, Kerala, India, Truman Sona , R L Anand ,   Assistant Commandant/ Medical Officer at Indo Tibetan Border Police Force, India, K B Priya ,   Head of the department of Physiology, Government Medical College, Ernakulam, Kerala, India
Published: April 2024

Background: Tapioca is one of the staple foods of the people of Kerala. If it is not prepared properly during cooking the cyanide present in it will interfere with body functions. The cyanide is metabolized into thiocyanate by the liver. Thiocyanate has been shown to interact with the blood pressure and thyroid function. Objectives: The objectives of the study are to observe the variation in physiology of the human body due to the effect of low dose cyanide in diet on the blood pressure and thyroid function. Materials and methods: A descriptive cross-sectional study design was conducted in the department of General Medicine out-patient department of a tertiary care hospital of central Kerala. This research was conducted after obtaining ethical clearance from the institutional ethical committee. The blood pressure of each subject was recorded. The fasting TSH values of each subject were determined. Results: There were no significant changes in the systolic blood pressure in hypothyroid group (p=0.288) and hyperthyroid group (p=0.915). There were no significant changes in diastolic blood pressure in hypothyroid group (p=0.270) and in hyperthyroid group (p=0.813). There was significant difference in TSH values in the hypothyroid group (p=0.001) and in the hyperthyroid group (p=0.001) compared to the matched controls. Conclusions: The above study did not show significant changes in the systolic and diastolic blood pressure compared to matched controls. These findings are unusual since thyroid dysfunction is known to cause increase in blood pressure as seen in various other studies. This means low dose cyanide in diet in a population with cassava as staple food might be protective from hypertension and is good for the cardiovascular system. There was significant increase in TSH values in the hypothyroid group. There was significant decrease in TSH values in hyperthyroid group. These findings are comparable with the values obtained in other studies.
PRINCIPLES AND METHODS OF INTENSIVE ENGLISH LANGUAGE TEACHING IN EDUCATIONAL COURSES
Authors:   Lecturer, Uzbekistan State University of World Languages, Uzbekistan, Tolibova Gulnoz R.
Published: April 2024

This article delves into the principles and methods employed in intensive English language teaching within educational courses. Recognizing the increasing demand for proficiency in English, educational institutions are adopting intensive teaching approaches to accelerate language acquisition. The article explores various pedagogical approaches, curriculum designs, and assessment strategies that facilitate effective and efficient learning. Emphasis is placed on student engagement, immersion techniques, and the integration of technology to enhance the learning experience.
USE OF BASALT AND CLAY MATERIALS IN THE COMPOSITION OF CERAMIC MASSES
Authors:   Doctoral student of Institute of General and Inorganic Chemistry of Academy of Sciences of the Republic of Uzbekistan, Tashkent, Uzbekistan, Aleuatdinovich Kalbaev Bakhauatdin , Mamurovich Eminov Ashrap ,   Doctor of Technical Sciences, Prof. Head of the Yangier branch of Tashkent Institute of Chemical Technology Department, Yangier, Uzbekistan, Lutpullayevich Usmanov Khikmatulla ,   Doctor of Sciences, Institute of General and Inorganic Chemistry of Academy of Sciences of the Republic of Uzbekistan, Uzbekistan, Mansuraliyevna Niyazova Shokhista ,   PhD, Institute of General and Inorganic Chemistry of Academy of Sciences of the Republic of Uzbekistan, Uzbekistan
Published: April 2024

The article examines the chemical mineral composition, the formation of crystalline phases of minerals, the basic properties of ceramic masses with igneous rocks and the formation of minerals during the sintering process in the temperature range 950-1150°C. The results obtained indicate that the introduction of iron-containing basalts stabilizes the structure of ceramic slabs and reduces their sintering temperature. According to geological data, kaolins from the Republic of Karakalpakstan are promising for use.
Turismo Sustentable o Sostenible en Sudamérica: ¿Qué se Investiga en el Campo Científico?
Authors: Carranza Evelyn Garcia
Published: April 2024

El turismo sostenible o turismo sustentable genera desarrollo en las economías al igual que en sus entornos de bienestar social, en la constante búsqueda de minorar el impacto que tienen las actividades turísticas al medioambiente y a las culturas locales de una región. El objetivo de la investigación es analizar los aportes en el campo científico y académico de los emprendimientos en el sector turístico en el contexto de la sustentabilidad con el entorno dentro de Sudamérica. La metodología utilizada fue de tipo descriptiva- cuantitativa a través de un análisis bibliográfico se escogió la plataforma Web of Science (W.O.S.) por contener un alto número de revista de calidad e impacto en la comunidad científica en las áreas de ciencias sociales, se obtuvieron 251 artículos en la colección principal que representan documentos de acceso abierto con el criterio de búsqueda “Tourism” AND “Sustainability” AND “South America” desde el año 2003 hasta el 2022. Los principales resultados dieron a conocer que los autores que más se dedican a este tipo de investigaciones son: Carrión-Mero, Carvache-Franco, Kline C. y Lobo Has. Además, que los países que se desarrollan emprendimientos turísticos sustentables o sostenibles son los países de Brasil, Colombia y Ecuador. La principal conclusión determina que las pymes dentro de áreas rurales se encuentran más motivadas para ser sostenibles, desenvuelven su actividad en espacios naturales protegidos y creen que el apoyo de instituciones públicas y privadas es vital para el desarrollo de actividades económicas buscando la conservación natural del planeta.
Morphological characterization of some local watermelon (Citrullus lanatus L.) genotypes of Turkey
Authors: Şahin Nihan
Published: April 2024

The scope of this study, some of the local Turkish watermelon genotypes were evaluated morphologically. A total of 20 local genotypes and three commercial varieties were assessed regarding their cotyledon, leaf, fruit, and seed phenotypes. An extensive morphological analysis was performed on a diverse set of genotypes. Traits such as cotyledon shape and color intensity, leaf size and lobing, and fruit size, shape, and color were measured and compared. Hierarchical clustering analysis, correlation matrices, and principal component analysis were employed to interpret the data. The study revealed significant morphological variability among the watermelon genotypes. Cotyledons ranged from narrow to broad, with a predominance of large sizes and dark green coloration. Leaf characteristics varied widely, with a notable distribution across different sizes and degrees of lobing. Fruit analysis showed a broad spectrum of shapes, sizes, and colors, indicating a rich genetic diversity. Two main genotype clusters were identified, suggesting a clear distinction based on morphological traits.
Décrire pour continuer d’exister
Authors: Tabouret Sophie
Published: April 2024

Les vins de qualité se sont construits en France autour de la notion de « terroir ». La définition de celle-ci est cependant très controversée. Geneviève Teil oppose, dans ses travaux, la dichotomie entre un terroir qui serait défini par les sciences dites objectives et un terroir qui serait pratiqué et vécu par les vignerons (Teil 2011). Cet article s’attache à montrer comment des œnologues travaillent avec et sur les terroirs viticoles. A partir de l’exemple des rosés de Provence, l’article analyse les dispositifs mis en œuvre par les scientifiques qui permettent de faire ressortir les surprises concernant l’étude des vins et de leurs typicités. Le terroir n’est plus considéré comme un élément à définir et à objectiver par des indicateurs à stabiliser. Au contraire, il doit être pris en charge par les chercheurs et les participants aux dégustations du Centre du Rosé, dans les débordements du goût. Les goûts du terroir sont alors pris en considération dans leur complexité et dans leur difficulté à se laisser stabiliser.
Étude de la dynamique de l'occupation des sols du bassin versant de la rivière Mulet à Roche-à-Bateau, Haïti
Authors: Mardy Zurcher , Waaub Jean-Philippe , Weissenberger Sebastian
Published: April 2024

En Haïti, et notamment dans le bassin versant de la rivière Mulet, la dégradation des milieux représente un problème préoccupant. Dans le souci de documenter l'évolution de ce bassin versant, nous avons analysé la dynamique de l'occupation des sols sur une période de 40 ans (1979-2019) à l'aide d'images satellitaires Landsat de référence (1979, 1989, 1999, 2009, 2019) et par des entretiens avec des exploitants agricoles. Les résultats obtenus ont révélé que le bassin versant a connu des changements remarquables. Sur l'ensemble de la période d'étude, les systèmes agro-sylvo-pastoraux sont la seule unité à avoir décliné, et cela sans discontinuer. Les savanes et les cultures agricoles denses ont augmenté, mais pas de façon régulière. Enfin, les affleurements de roches et sols nus se sont étendus toujours plus. Ces évolutions ont eu pour cause des contraintes économiques (effondrement des prix mondiaux du café et du cacao), un contexte politique incertain depuis 1986, qui empêche l'application de mesures de protection de l'environnement, et une succession d'événements météorologiques extrêmes (sécheresses, tempêtes, ouragans). La mise en culture sans précaution de nouvelles parcelles sur des pentes le plus souvent très fortes participe fortement à l'amplification de l'érosion des sols.
Relationship between Helicobacter pylori infection and colorectal polyp/colorectal cancer
Authors: Liu Ying , Yang Ding-Quan , Jiang Jun-Nan , Jiao Yan
Published: April 2024

Helicobacter pylori (H. pylori ) plays an important role in the development of gastric cancer, although its association to colorectal polyp (CP) or colorectal cancer (CRC) is unknown. In this issue of World Journal of Gastrointestinal Surgery , Zhang et al investigated the risk factors for H. pylori infection after colon polyp resection. Importantly, the researchers used R software to create a prediction model for H. pylori infection based on their findings. This editorial gives an overview of the association between H. pylori and CP/CRC, including the clinical significance of H. pylori as an independent risk factor for CP/CRC, the underlying processes of H. pylori -associated carcinogenesis, and the possible risk factors and identification of H. pylori .
Near-infrared cholangiography with intragallbladder indocyanine green injection in minimally invasive cholecystectomy
Authors: Symeonidis Savvas , Mantzoros Ioannis , Anestiadou Elissavet , Ioannidis Orestis , Christidis Panagiotis , Bitsianis Stefanos , Bisbinas Vasiliki , Zapsalis Konstantinos , Karastergiou Trigona , Athanasiou Dimitra , Apostolidis Stylianos , Angelopoulos Stamatios
Published: April 2024

Laparoscopic cholecystectomy (LC) remains one of the most commonly performed procedures in adult and paediatric populations. Despite the advances made in intraoperative biliary anatomy recognition, iatrogenic bile duct injuries during LC represent a fatal complication and consist an economic burden for healthcare systems. A series of methods have been proposed to prevent bile duct injury, among them the use of indocyanine green (ICG) fluorescence. The most commonly reported method of ICG injection is the intravenous administration, while literature is lacking studies investigating the direct intragallbladder ICG injection. This narrative mini-review aims to assess the potential applications, usefulness, and limitations of intragallbladder ICG fluorescence in LC. Authors screened the available international literature to identify the reports of intragallbladder ICG fluorescence imaging in minimally invasive cholecystectomy, as well as special issues regarding its use. Literature search retrieved four prospective cohort studies, three case-control studies, and one case report. In the three case-control studies selected, intragallbladder near-infrared cholangiography (NIRC) was compared with standard LC under white light, with intravenous administration of ICG for NIRC and with standard intraoperative cholangiography (IOC). In total, 133 patients reported in the literature have been administered intragallbladder ICG administration for biliary mapping during LC. Literature includes several reports of intragallbladder ICG administration, but a standardized technique has not been established yet. Published data suggest that NIRC with intragallbladder ICG injection is a promising method to achieve biliary mapping, overwhelming limitations of IOC including intervention and radiation exposure, as well as the high hepatic parenchyma signal and time interval needed in intravenous ICG fluorescence. Evidence-based guidelines on the role of intragallbladder ICG fluorescence in LC require the assessment of further studies and multicenter data collection into large registries.
Blastomas of the digestive system in adults: A review
Authors: Liu Yu , El Jabbour Tony , Somma Jonathan , Nakanishi Yukihiro , Ligato Saverio , Lee Hwajeong , Fu Zhi-Yan
Published: April 2024

Blastomas, characterized by a mixture of mesenchymal, epithelial, and undifferentiated blastematous components, are rare malignant neoplasms originating from precursor blast cells. This review focuses on digestive system blastomas in adult patients, including gastroblastoma, hepatoblastoma, and pancreatoblastoma. Gastroblastoma is a biphasic, epitheliomesenchymal tumor, with only sixteen cases reported to date. In addition to the characteristic histology, metastasis-associated lung adenocarcinoma transcript 1 - glioma-associated oncogene homolog 1 gene fusion is typical, although recently novel ewing sarcoma breakpoint region 1 - c-terminal binding protein 1 and patched 1 - glioma-associated oncogene homolog 2 fusions have been described. Hepatoblastoma is exceptionally rare in adults and can show a variety of histologic patterns which may cause diagnostic difficulty. Pancreatoblastoma, primarily a pediatric tumor, displays acinar differentiation and squamoid nests with other lines of differentiation also present, especially neuroendocrine. Diagnostic approaches for these blastomas include a combination of imaging modalities, histopathological examination, and molecular profiling. The treatment generally involves surgical resection, which may be supplemented by chemotherapy or radiotherapy in some cases. Prognoses vary with gastroblastoma generally showing favorable outcomes post-surgery whereas hepatoblastoma and pancreatoblastoma often have poorer outcomes, particularly in the setting of metastases. This review highlights the complexity of diagnosing and managing these rare adult blastomas as well as the need for ongoing research to better understand their pathogenesis and improve treatment strategies.
Computer-assisted three-dimensional individualized extreme liver resection for hepatoblastoma in proximity to the major liver vasculature
Authors: Xiu Wen-Li , Liu Jie , Zhang Jing-Li , Wang Jing-Miao , Wang Xue-Feng , Wang Fei-Fei , Mi Jie , Hao Xi-Wei , Xia Nan , Dong Qian
Published: April 2024

BACKGROUND

The management of hepatoblastoma (HB) becomes challenging when the tumor remains in close proximity to the major liver vasculature (PMV) even after a full course of neoadjuvant chemotherapy (NAC). In such cases, extreme liver resection can be considered a potential option.

AIM

To explore whether computer-assisted three-dimensional individualized extreme liver resection is safe and feasible for children with HB who still have PMV after a full course of NAC.

METHODS

We retrospectively collected data from children with HB who underwent surgical resection at our center from June 2013 to June 2023. We then analyzed the detailed clinical and three-dimensional characteristics of children with HB who still had PMV after a full course of NAC.

RESULTS

Sixty-seven children diagnosed with HB underwent surgical resection. The age at diagnosis was 21.4 ± 18.8 months, and 40 boys and 27 girls were included. Fifty-nine (88.1%) patients had a single tumor, 39 (58.2%) of which was located in the right lobe of the liver. A total of 47 patients (70.1%) had PRE-TEXT III or IV. Thirty-nine patients (58.2%) underwent delayed resection. After a full course of NAC, 16 patients still had close PMV (within 1 cm in two patients, touching in 11 patients, compressing in four patients, and showing tumor thrombus in three patients). There were 6 patients of tumors in the middle lobe of the liver, and four of those patients exhibited liver anatomy variations. These 16 children underwent extreme liver resection after comprehensive preoperative evaluation. Intraoperative procedures were performed according to the preoperative plan, and the operations were successfully performed. Currently, the 3-year event-free survival of 67 children with HB is 88%. Among the 16 children who underwent extreme liver resection, three experienced recurrence, and one died due to multiple metastases.

CONCLUSION

Extreme liver resection for HB that is still in close PMV after a full course of NAC is both safe and feasible. This approach not only reduces the necessity for liver transplantation but also results in a favorable prognosis. Individualized three-dimensional surgical planning is beneficial for accurate and complete resection of HB, particularly for assessing vascular involvement, remnant liver volume and anatomical variations.
Construction of a predictive model for acute liver failure after hepatectomy based on neutrophil-to-lymphocyte ratio and albumin-bilirubin score
Authors: Li Xiao-Pei , Bao Zeng-Tao , Wang Li , Zhang Chun-Yan , Yang Wen
Published: April 2024

BACKGROUND

Acute liver failure (ALF) is a common cause of postoperative death in patients with hepatocellular carcinoma (HCC) and is a serious threat to patient safety. The neutrophil-to-lymphocyte ratio (NLR) is a common inflammatory indicator that is associated with the prognosis of various diseases, and the albumin-bilirubin score (ALBI) is used to evaluate liver function in liver cancer patients. Therefore, this study aimed to construct a predictive model for postoperative ALF in HCC tumor integrity resection (R0) based on the NLR and ALBI, providing a basis for clinicians to choose appropriate treatment plans.

AIM

To construct an ALF prediction model after R0 surgery for HCC based on NLR and ALBI.

METHODS

In total, 194 patients with HCC who visited The First People’s Hospital of Lianyungang to receive R0 between May 2018 and May 2023 were enrolled and divided into the ALF and non-ALF groups. We compared differences in the NLR and ALBI between the two groups. The risk factors of ALF after R0 surgery for HCC were screened in the univariate analysis. Independent risk factors were analyzed by multifactorial logistic regression. We then constructed a prediction model of ALF after R0 surgery for HCC. A receiver operating characteristic curve, calibration curve, and decision curve analysis (DCA) were used to evaluate the value of the prediction model.

RESULTS

Among 194 patients with HCC who met the standard inclusion criteria, 46 cases of ALF occurred after R0 (23.71%). There were significant differences in the NLR and ALBI between the two groups (P < 0.05). The univariate analysis showed that alpha-fetoprotein (AFP) and blood loss volume (BLV) were significantly higher in the ALF group compared with the non-ALF group (P < 0.05). The multifactorial analysis showed that NLR, ALBI, AFP, and BLV were independent risk factors for ALF after R0 surgery in HCC. The predictive efficacy of NLR, ALBI, AFP, and BLV in predicting the occurrence of ALT after R0 surgery for HCC was average [area under the curve (AUC)NLR = 0.767, AUCALBI = 0.755, AUCAFP = 0.599, AUCBLV = 0.718]. The prediction model for ALF after R0 surgery for HCC based on NLR and ALBI had a better predictive efficacy (AUC = 0.916). The calibration curve and actual curve were in good agreement. DCA showed a high net gain and that the model was safer compared to the curve in the extreme case over a wide range of thresholds.

CONCLUSION

The prediction model based on NLR and ALBI can effectively predict the risk of developing ALF after HCC R0 surgery, providing a basis for clinical prevention of developing ALF after HCC R0 surgery.
Suspected coexistence of perianal necrotizing sweet syndrome in chronic myelomonocytic leukemia: A case report
Authors: Yu Ke-Qiang , Li Hui-Xiang , Wu Jing
Published: April 2024

BACKGROUND

Chronic myelomonocytic leukemia (CMML) complicated with Sweet syndrome (SS) is a rare hematological neoplasm. However, cases of concomitant development of perianal necrotizing SS (NSS) have not been reported.

CASE SUMMARY

We report a case of a 49-year-old male patient who underwent sequential procedures for hemorrhoids and perianal abscess. He developed postoperative incision infection and was referred to the department where the authors work. Initially, perianal necrotizing fasciitis secondary to incision infection after perianal abscess surgery was suspected. Despite receiving antibiotic therapy and undergoing surgical debridement, deeper necrotic areas formed in the patient’s perianal wounds, accompanied by persistent high fever. Blood and fungal cultures yielded negative results. The final diagnosis was corrected to be CMML with suspected concomitant perianal NSS.

CONCLUSION

CMML with perianal NSS is a rare condition, often misdiagnosed as perianal abscess or perianal necrotizing fasciitis. Conventional antibiotic therapy and surgical debridement are ineffective in managing this condition.
Stercoral perforation of the cecum: A case report
Authors: Yu Hung-Chun , Pu Ta-Wei , Kang Jung-Cheng , Chen Chao-Yang , Hu Je-Ming , Su Ruei-Yu
Published: April 2024

BACKGROUND

With less than 90 reported cases to date, stercoral perforation of the colon is a rare occurrence. Stercoral ulceration is thought to occur due to ischemic pressure necrosis of the bowel wall, which is caused by the presence of a stercoraceous mass. To underscore this urgent surgical situation concerning clinical presentation, surgical treatment, and results, we present the case of a 66-year-old man with a stercoral perforation.

CASE SUMMARY

A 66-year-old man with a history of hypertension, hyperlipidemia, and gout presented at the emergency department with lower abdominal pain and a low-grade fever lasting for a few hours. Abdominal computed tomography indicated a suspected bezoar (approximately 7.6 cm) in the dilated cecum, accompanied by pericolic fat stranding, mild proximal dilatation of the ileum, pneumoperitoneum, and minimal ascites. Intraoperatively, feculent peritonitis with isolated cecal perforation were observed. Consequently, a right hemicolectomy with peritoneal lavage was performed. A histopathological examination supported the intraoperative findings.

CONCLUSION

In stercoral perforations, a diagnosis should be diligently pursued, especially in older adults, and prompt surgical intervention should be implemented.
Percutaneous transhepatic stenting for acute superior mesenteric vein stenosis after pancreaticoduodenectomy with portal vein reconstruction: A case report
Authors: Lin Chen , Wang Zi-Yan , Dong Liang-Bo , Wang Zhi-Wei , Li Ze-Hui , Wang Wei-Bin
Published: April 2024

BACKGROUND

Percutaneous transhepatic stent placement has become a common strategy for the postoperative treatment of portal vein (PV)/superior mesenteric veins (SMV) stenosis/occlusion. It has been widely used after liver transplantation surgery; however, reports on stent placement for acute PV/SMV stenosis after pancreatic surgery within postoperative 3 d are rare.

CASE SUMMARY

Herein, we reported a case of intestinal edema and SMV stenosis 2 d after pancreatic surgery. The patient was successfully treated using stent grafts. Although the stenosis resolved after stent placement, complications, including bleeding, pancreatic fistula, bile leakage, and infection, made the treatment highly challenging. The use of anticoagulants was adjusted multiple times to prevent venous thromboembolism and the risk of bleeding. After careful treatment, the patient stabilized, and stent placement effectively managed postoperative PV/SMV stenosis.

CONCLUSION

Stent placement is effective and feasible for treating acute PV/SMV stenosis after pancreatic surgery even within postoperative 3 d.
Emerging molecules, tools, technology, and future of surgical knife in gastroenterology
Authors: Kumar Ashok , Goyal Anirudh
Published: April 2024

The 21st century has started with several innovations in the medical sciences, with wide applications in health care management. This development has taken in the field of medicines (newer drugs/molecules), various tools and technology which has completely changed the patient management including abdominal surgery. Surgery for abdominal diseases has moved from maximally invasive to minimally invasive (laparoscopic and robotic) surgery. Some of the newer medicines have its impact on need for surgical intervention. This article focuses on the development of these emerging molecules, tools, and technology and their impact on present surgical form and its future effects on the surgical intervention in gastroenterological diseases.
Aplicación de las Tecnologías del Aprendizaje y el Conocimiento para favorecer la Educación Inclusiva
Authors: García de Verbena Angela del Rosario
Published: April 2024

OBJETIVO: En este estudio se determinó el nivel de aplicación de las Tecnologías del Aprendizaje y el Conocimiento(TAC) para favorecer la educación inclusiva en el ciclo básico. MÉTODO: Se basó  en el paradigma postpositivista, con enfoque mixto, alcance descriptivo, diseño transeccional descriptivo, muestreo por conveniencia para docentes y aleatorio simple para estudiantes. Se aplicó una encuesta a 147 estudiantes y 35 docentes y  entrevista a 2 profesionales de educación especial y educación alternativa. RESULTADOS: El nivel de aplicación de las tecnologías del aprendizaje y el conocimiento  por los docentes y estudiantes se encuentra en el nivel medio siendo las más utilizadas  Canva y Power Point; una por ser considerada muy completa porque contiene diferentes recursos para transformar el conocimiento y  otra por ser fácil de utilizar y  no requiere inversión de internet y que al implementar las metodologías basadas en TAC, favorece la inclusión de los estudiantes vulnerables en el proceso de enseñanza aprendizaje. Datos que se relacionan positivamente con la entrevista. CONCLUSIÓN: Se determinó que las tecnologías del aprendizaje y el conocimiento son aplicadas en un nivel medio, desde el punto de vista de estudiantes y docentes, lo que significa que la aplicación de las TAC reúne los requerimientos mínimos para favorecer la educación inclusiva en el ciclo básico y que los programas de educación alternativa del Ministerio de Educación implementan las TAC en el proceso de enseñanza aprendizaje, lo favorece a los jóvenes en condición vulnerable.
EMPOWERING SMALL-SCALE DAIRY PROCESSORS: A COMPREHENSIVE ANALYSIS OF TRAINING IMPACT AND PARTICIPANT FEEDBACK
Authors:   University of Belgrade, Faculty of Agriculture, Serbia, Miloradović Zorana , Kovačević Jovana , Miočinović Jelena ,   University of Belgrade, Faculty of Agriculture, Serbia, Đekić Ilija ,   University of Belgrade, Faculty of Agriculture, Serbia, Šmigić Nada ,   University of Belgrade, Faculty of Agriculture, Serbia
Published: April 2024

To overcome obstacles faced by small scale dairy processors (SSDPs) in Serbia, a training program was implemented. Two phases of training evaluation (reaction and learning) were conducted. A demographic breakdown showed that it was difficult to achieve gender and educational projections. Reaction evaluation demonstrated the highest satisfaction with the overall quality of the training. The main concern was related to the training duration, which led to plans for e-learning training. It was recognised that it is difficult to attract young people, women and participants with low level of education.
MICROBIOLOGICAL SAFETY OF FOOD OF ANIMAL ORIGIN IN BELGRADE RESTAURANTS AND CATERING FACILITIES 20242ND INTERNATIONAL SYMPOSIUM ON BIOTECHNOLOGY (2024)ЗБОРНИЦИ
Authors:   University of Belgrade, Faculty of Veterinary Medicine, Serbia, Savić Radovanović Radoslava , Sinđić Milijana ,   University of Belgrade, Faculty of Veterinary Medicine, Serbia, Aleksić Radojković Jelena ,   University of Belgrade, Faculty of Veterinary Medicine, Serbia, Janićijević Slobodanka ,   Ministry of Agriculture, Forestry and Water Management, Belgrade, Serbia
Published: April 2024

Total of 40 samples of food of animal origin were analyzed during monitoring in 2023. Out of 40 samples in 3 (7.5%) ice cream samples was dectected presence od Enterobacteriacae. All 30 samples of sandwiches and sushi examined for the presence of Listeria monocytogenes and Salmonellae spp. were negative. It can be concluded that food of animal origin in Belgrade restaurants was safe for consumption, except 3 (7.5%) samples of ice cream who were not satisfactory to hygiene criteria.
FORMATION OF HYDROXYMETHYLFURFURAL DURING THE INDUSTRIAL PRODUCTION OF PLUM PEKMEZ
Authors:   University of Kragujevac, Faculty of Agronomy, Serbia, Radovanović Mirjana , Jovićević Marija ,   University of Kragujevac, Faculty of Agronomy, Serbia, Miletić Nemanja ,   University of Kragujevac, Faculty of Agronomy, Serbia, Petković Marko ,   University of Kragujevac, Faculty of Agronomy, Serbia, Đurović Vesna ,   University of Kragujevac, Faculty of Agronomy, Serbia
Published: April 2024

It was analyzed the industrial plum pekmez production: blanching, mashing, cooking blanched plum pulp with invert sugar solution and caramel, final heat treatment, cooling pekmez and surface treatment. The aim was to determine the critical stages in which hydroxymethylfurfural (HMF) forms. HMF is synthesized by the thermal sugar decomposition or as one product of the Maillard reaction and can be an indicator of the thermal degree of food processing. Also, HMF is a quality parameter of food due to its potentially harmful effect on consumer health. The cooking blanched plum pulp was a critical stage when the HMF content was significant increased.
QUALITY OF MINCED MEAT PRODUCTS
Authors:   University of Belgrade, Faculty of Agriculture, Serbia, Đurđević Sanja , Tomašević Igor ,   University of Belgrade, Faculty of Agriculture, Serbia, Stajić Slaviša ,   University of Belgrade, Faculty of Agriculture, Serbia, Živković Dušan ,   University of Belgrade, Faculty of Agriculture, Serbia
Published: April 2024

Minced meat is a popular and widely consumed food worldwide. The quality of meat products is often associated with microbiological correctness, sustainability, and sensory properties. The quality of minced meat and minced meat products is affected by a variety of factors. The European Union (EU) has established regulations to standardize and enhance the quality of minced meat products. Adherence to these regulations plays a crucial role in meeting the desired nutritional composition and sensory attributes of minced meat products.
BIOACTIVE POWER OF LYOPHILIZED PLANT RAW MATERIALS: EVALUATION AND ASSESSMENT OF SUITABILITY FOR THE PRODUCTION OF NATURAL FOOD SUPPLEMENTS AND ANTIMICROBIAL DRUGS
Authors:   University of Kragujevac, Faculty of Agronomy, Serbia, Kurćubić Vladimir S. , Živković Saša ,   Veterinary Specialist Institute “Kraljevo”, Serbia, Dmitrić Marko ,   Veterinary Specialist Institute “Kraljevo”, Serbia, Stajić Slaviša ,   University of Belgrade, Faculty of Agriculture, Serbia, Kurćubić Luka V. ,   University Clinical Center of Serbia, Department of Medical Microbiology
Published: April 2024

Superior preservation and utilization of bioactive compounds (BAC) from plants, secondary or by-products of fruit and vegetable processing, can be achieved by lyophilization, witout chemicals used, so it is possible to deliver the highest level of BAC to consumers or specific groups, with environmentally friendly and effective products or dietary supplements. In this review paper, we will present the experiences of researchers worldwide and the opinion of our team on the possibilities of creating foods or dietary supplements modified by BAC from various synergistic phytocomplexes, superior bioactivity: in the lowest concentrations, proven positive effects on human health, with intact sensory and techno-functional properties of enriched food, attractive to consumers.
EXAMINATION OF THE SURVIVAL OF Lactobacillus plantarum AND Lactobacillus rhamnosus DURING KOMBUCHA FERMENTATION
Authors:   University of Novi Sad, Faculty of Technology Novi Sad, Serbia, Cvetković Dragoljub , Ranitović Aleksandra ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia, Budimac Tara ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia, Šovljanski Olja ,   University of Novi Sad, Faculty of Technology Novi Sad, Serbia
Published: April 2024

Kombucha is a traditional fermented beverage, which is usually prepared by fermenting sweetened black tea using a symbiotic consortium of acetic acid bacteria and yeasts. Kombucha exhibits several functional properties, it still can’t be labelled as a probiotic product. In this study, Lactobacillus plantarum and Lactobacillus rhamnosus were added separately at the start of the fermentation to examine their survival during fermentation conditions. Microbiological and chemical parameters were tested during 5 days of Kombucha fermentation. Sample inoculated with L. plantarum demonstrated better survivability, but number was not enough to label the beverage as probiotic.
OPTIMIZATION OF ULTRASONIC-ASSISTED EXTRACTION OF PHENOLIC COMPOUNDS FROM SALVIA VERTICILLATA L. ROOT USING RESPONSE SURFACE METHODOLOGY
Authors:   University of Kragujevac, Faculty of Science, Serbia, Mihailović Nevena , Ćirić Andrija ,   University of Kragujevac, Faculty of Science, Serbia, Srećković Nikola ,   University of Kragujevac, Faculty of Science, Serbia, Mihailović Vladimir ,   University of Kragujevac, Faculty of Science, Serbia, Joksović Ljubinka ,   University of Kragujevac, Faculty of Science, Serbia, Kreft Samo ,   University of Ljubljana, Faculty of Pharmacy, Slovenia
Published: April 2024

This study aimed to optimize the conditions of ultrasonic-assisted extraction to obtain the highest content of phenolic compounds from Salvia verticillata L. root using response surface methodology. RSM was applied to maximize total phenolic content from Salvia verticillata L. root while minimizing operative temperature, ethanol composition, the solvent-to-solid ratio, and time. The obtained optimal conditions were ethanol percentage of 20 %, solvent-to-solid ratio of 40 mL g-1 Salvia verticillata L. is (lilac sage) belongs to the genus Salvia (Lamiaceae). Salvia plants have applications in the food, aromatic, and pharmaceutical , a temperature of 33.68 °C, and a time of extraction of 10 minutes. Obtained optimal conditions could be used for further investigation of the biological activities of Salvia verticillata L. and related plant species.
PHENOLIC CONTENT AND ANTIOXIDANT PROPERTIES OF SOME NATURAL COSMETIC CREAMS WITH PLANT-DERIVED INGREDIENTS AVAILABLE ON THE SERBIAN MARKET
Authors:   University of Kragujevac, Faculty of Science, Serbia, Mihailović Nevena , Mihailović Vladimir ,   University of Kragujevac, Faculty of Science, Serbia, Srećković Nikola ,   University of Kragujevac, Faculty of Science, Serbia
Published: April 2024

The main goal of this study is to determine some properties of natural cosmetic creams that may have benefits for the skin. Five different cosmetic cream formulations with ingredients of botanical origin such as plant extracts, plant oil macerates, or essential oils were subjected to determine their phenolic content and antioxidant activity using the DPPH method. Total phenolic compounds were detected in all tested samples in the range of 1.7 to 0.2 mg GA/g but some samples did not contain flavonoids and did not possess antioxidant activity. The highest phenolic content and the strongest antioxidant activity were recorded for samples with the highest number of ingredients of plant origin.
FATTY ACIDS CONTENT IN WATERMELON, MELON, SQUASH AND ZUCCHINI SEEDS
Authors:   University of Niš, Faculty of Sciences and Mathematics, Serbia, Petrović Goran , Đorđević Aleksandra ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Stamenković Jelena ,   University of Niš, Faculty of Medicine, Serbia, Dimitrijević Marija ,   University of Niš, Faculty of Medicine, Serbia, Nikolić Jelena ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Stankov Jovanović Vesna ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Mitić Violeta ,   University of Niš, Faculty of Sciences and Mathematics, Serbia
Published: April 2024

Seed samples of ten zucchini, melon, squash and watermelon samples were examined by gas chromatography-mass spectrometry (GC-MS) analysis for the presence of fatty acids. Fatty acid composition was significantly different among various samples. Hexadecanoic acid was found in all analyzed seed samples, whereas 9,12,15-octadecanoic acid was found only in zucchini seed samples. Unsaturated fatty acids, which possess multiple health benefits, were present in all samples, in various amounts. The high concentration of essential unsaturated fatty acids in analyzed seed samples indicates that they could be used as a source of these valuable compounds in human nutrition.
UPTAKE OF HEAVY METALS BY WHITE CLOVER (TRIFOLIUM REPENS L.) – POT EXPERIMENT
Authors:   University of Niš, Faculty of Sciences and Mathematics, Serbia, Petrović Stefan , Mitov Denis ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Ranđelović Aleksandar ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Mrmošanin Jelena ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Pavlović Aleksandra ,   University of Niš, Faculty of Sciences and Mathematics, Serbia, Tošić Snežana ,   University of Niš, Faculty of Sciences and Mathematics, Serbia
Published: April 2024

This study investigated the uptake of some heavy metals (Cd, Cr, Cu, Ni, and Pb) by white clover (Trifolium repens L.) using a pot experiment. Plant and soil samples were prepared through wet digestion and analyzed by ICP-OES. The obtained results were discussed in terms of metal concentrations, translocation factors (TF), and enrichment factors (EF). Metal concentrations were higher in the roots compared to the shoots of the plant. White clover growing in Cd-contaminated soil absorbed significant amounts of Cd in both the roots and aboveground parts.