bluuebunny/crossref_metadata_2025 huggingface dataset:
О глубине мультиплексорной функции от "небольшого" числа адресных переменных
Authors: Lozhkin Sergei Andreevich
Published: May 2024

Продолжается исследование задачи синтеза схем для мультиплексорной
функции алгебры логики, которая часто является составной частью интегральных схем, а также используется в теоретических исследованиях. В стандартном базисе при условии, что элементы конъюнкции и дизъюнкции имеют глубину 1, а элемент отрицания - глубину 0, устанавливается точное значение глубины мультиплексорной функции от $n$ адресных переменных, равное $(n+2)$, если $10 \leqslant n \leqslant 19$. Тем самым, учитывая полученные ранее результаты, точное значение указанной глубины, равное $(n+2)$, установлено для всех натуральных $n$ таких, что $2 \leqslant n \leqslant 5$ и $n \geqslant 10$. При этом для $n=1$ данное значение равно 2, а для $6 \leqslant n \leqslant 9$ равно либо $(n+2)$, либо $(n+3)$. Аналогичные результаты справедливы также для базиса, состоящего из всех элементарных конъюнкций и элементарных дизъюнкций от двух переменных
Библиография: 13 названий.
Different lymph node staging systems for predicting the prognosis of colorectal neuroendocrine neoplasms
Authors: Zhang Yuan-Yi , Cai Yue-Wei , Zhang Xia
Published: May 2024

BACKGROUND

Colorectal neuroendocrine neoplasms (NENs) are a rare malignancy that primarily arises from the diffuse distribution of neuroendocrine cells in the colon and rectum. Previous studies have pointed out that the status of lymph node may be used to predict the prognosis.

AIM

To investigate the predictive values of lymph node ratio (LNR), positive lymph node (PLN), and log odds of PLNs (LODDS) staging systems on the prognosis of colorectal NENs treated surgically, and compare their predictive values.

METHODS

This cohort study included 895 patients with colorectal NENs treated surgically from the Surveillance, Epidemiology, and End Results database. The endpoint was mortality of patients with colorectal NENs treated surgically. X-tile software was utilized to identify most suitable thresholds for categorizing the LNR, PLN, and LODDS. Participants were selected in a random manner to form training and testing sets. The prognosis of surgically treating colorectal NENs was examined using multivariate cox analysis to assess the associations of LNR, PLN, and LODDS with the prognosis of colorectal NENs. C-index was used for assessing the predictive effectiveness. We conducted a subgroup analysis to explore the different lymph node staging systems’ predictive values.

RESULTS

After adjusting all confounding factors, PLN, LNR and LODDS staging systems were linked with mortality in patients with colorectal NENs treated surgically (P < 0.05). We found that LODDS staging had a higher prognostic value for patients with colorectal NENs treated surgically than PLN and LNR staging systems. Similar results were obtained in the different G staging subgroup analyses. Furthermore, the area under the receiver operating characteristic curve values for LODDS staging system remained consistently higher than those of PLN or LNR, even at the 1-, 2-, 3-, 4-, 5- and 6-year follow-up periods.

CONCLUSION

LNR, PLN, and LODDS were found to significantly predict the prognosis of patients with colorectal NENs treated surgically.
TRIANGLE operation, combined with adequate adjuvant chemotherapy, can improve the prognosis of pancreatic head cancer: A retrospective study
Authors: Chen Jia-Hao , Zhu Li-Yong , Cai Zhi-Wei , Hu Xiao , Ahmed Abousalam Abdoulkader , Ge Jie-Qiong , Tang Xiao-Yan , Li Chun-Jing , Pu Yun-Long , Jiang Chong-Yi
Published: May 2024

BACKGROUND

The TRIANGLE operation involves the removal of all tissues within the triangle bounded by the portal vein-superior mesenteric vein, celiac axis-common hepatic artery, and superior mesenteric artery to improve patient prognosis. Although previously promising in patients with locally advanced pancreatic ductal adenocarcinoma (PDAC), data are limited regarding the long-term oncological outcomes of the TRIANGLE operation among resectable PDAC patients undergoing pancreaticoduodenectomy (PD).

AIM

To evaluate the safety of the TRIANGLE operation during PD and the prognosis in patients with resectable PDAC.

METHODS

This retrospective cohort study included patients who underwent PD for pancreatic head cancer between January 2017 and April 2023, with or without the TRIANGLE operation. Patients were divided into the PDTRIANGLE and PDnon-TRIANGLE groups. Surgical and survival outcomes were compared between the two groups. Adequate adjuvant chemotherapy was defined as adjuvant chemotherapy ≥ 6 months.

RESULTS

The PDTRIANGLE and PDnon-TRIANGLE groups included 52 and 55 patients, respectively. There were no significant differences in the baseline characteristics or perioperative indexes between the two groups. Furthermore, the recurrence rate was lower in the PDTRIANGLE group than in the PDnon-TRIANGLE group (48.1% vs 81.8%, P < 0.001), and the local recurrence rate of PDAC decreased from 37.8% to 16.0%. Multivariate Cox regression analysis revealed that PDTRIANGLE (HR = 0.424; 95%CI: 0.256-0.702; P = 0.001), adequate adjuvant chemotherapy ≥ 6 months (HR = 0.370; 95%CI: 0.222-0.618; P < 0.001) and margin status (HR = 2.255; 95%CI: 1.252-4.064; P = 0.007) were found to be independent factors for the recurrence rate.

CONCLUSION

The TRIANGLE operation is safe for PDAC patients undergoing PD. Moreover, it reduces the local recurrence rate of PDAC and may improve survival in patients who receive adequate adjuvant chemotherapy.
Nomogram prediction of vessels encapsulating tumor clusters in small hepatocellular carcinoma ≤ 3 cm based on enhanced magnetic resonance imaging
Authors: Chen Hui-Lin , He Rui-Lin , Gu Meng-Ting , Zhao Xing-Yu , Song Kai-Rong , Zou Wen-Jie , Jia Ning-Yang , Liu Wan-Min
Published: May 2024

BACKGROUND

Vessels encapsulating tumor clusters (VETC) represent a recently discovered vascular pattern associated with novel metastasis mechanisms in hepatocellular carcinoma (HCC). However, it seems that no one have focused on predicting VETC status in small HCC (sHCC). This study aimed to develop a new nomogram for predicting VETC positivity using preoperative clinical data and image features in sHCC (≤ 3 cm) patients.

AIM

To construct a nomogram that combines preoperative clinical parameters and image features to predict patterns of VETC and evaluate the prognosis of sHCC patients.

METHODS

A total of 309 patients with sHCC, who underwent segmental resection and had their VETC status confirmed, were included in the study. These patients were recruited from three different hospitals: Hospital 1 contributed 177 patients for the training set, Hospital 2 provided 78 patients for the test set, and Hospital 3 provided 54 patients for the validation set. Independent predictors of VETC were identified through univariate and multivariate logistic analyses. These independent predictors were then used to construct a VETC prediction model for sHCC. The model’s performance was evaluated using the area under the curve (AUC), calibration curve, and clinical decision curve. Additionally, Kaplan-Meier survival analysis was performed to confirm whether the predicted VETC status by the model is associated with early recurrence, just as it is with the actual VETC status and early recurrence.

RESULTS

Alpha-fetoprotein_lg10, carbohydrate antigen 199, irregular shape, non-smooth margin, and arterial peritumoral enhancement were identified as independent predictors of VETC. The model incorporating these predictors demonstrated strong predictive performance. The AUC was 0.811 for the training set, 0.800 for the test set, and 0.791 for the validation set. The calibration curve indicated that the predicted probability was consistent with the actual VETC status in all three sets. Furthermore, the decision curve analysis demonstrated the clinical benefits of our model for patients with sHCC. Finally, early recurrence was more likely to occur in the VETC-positive group compared to the VETC-negative group, regardless of whether considering the actual or predicted VETC status.

CONCLUSION

Our novel prediction model demonstrates strong performance in predicting VETC positivity in sHCC (≤ 3 cm) patients, and it holds potential for predicting early recurrence. This model equips clinicians with valuable information to make informed clinical treatment decisions.
Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome
Authors: Mu Fan , Hu Liang-Shuo , Xu Kun , Zhao Zhen , Yang Bai-Cai , Wang Yi-Meng , Guo Kun , Shi Jian-Hua , Lv Yi , Wang Bo
Published: May 2024

BACKGROUND

Although the benefits of antiviral therapy for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have been proven, researchers have not confirmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time (at least 24 wk) and patients who received remedial antiviral therapy just before radical resection for HBV-related HCC.

AIM

To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related HCC.

METHODS

A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was conducted. Considering the history of antiviral therapy, patients were assigned to remedial antiviral therapy and preoperative antiviral therapy groups.

RESULTS

Kaplan–Meier analysis revealed significant differences in overall survival (P < 0.0001) and disease-free survival (P = 0.035) between the two groups. Multivariate analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival (hazard ratio = 0.27; 95% confidence interval: 0.08-0.88; P = 0.030).

CONCLUSION

In patients with HBV-related HCC, it is ideal to receive preoperative long-term antiviral therapy, which helps patients tolerate more extensive hepatectomy; however, remedial antiviral therapy, which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL, can also result in improved outcomes.
Predictive model using four ferroptosis-related genes accurately predicts gastric cancer prognosis
Authors: Wang Li , Gong Wei-Hua
Published: May 2024

BACKGROUND

Gastric cancer (GC) is a common malignancy of the digestive system. According to global 2018 cancer data, GC has the fifth-highest incidence and the third-highest fatality rate among malignant tumors. More than 60% of GC are linked to infection with Helicobacter pylori (H. pylori) , a gram-negative, active, microaerophilic, and helical bacterium. This parasite induces GC by producing toxic factors, such as cytotoxin-related gene A, vacuolar cytotoxin A, and outer membrane proteins. Ferroptosis, or iron-dependent programmed cell death, has been linked to GC, although there has been little research on the link between H. pylori infection-related GC and ferroptosis.

AIM

To identify coregulated differentially expressed genes among ferroptosis-related genes (FRGs) in GC patients and develop a ferroptosis-related prognostic model with discrimination ability.

METHODS

Gene expression profiles of GC patients and those with H. pylori -associated GC were obtained from The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. The FRGs were acquired from the FerrDb database. A ferroptosis-related gene prognostic index (FRGPI) was created using least absolute shrinkage and selection operator–Cox regression. The predictive ability of the FRGPI was validated in the GEO cohort. Finally, we verified the expression of the hub genes and the activity of the ferroptosis inducer FIN56 in GC cell lines and tissues.

RESULTS

Four hub genes were identified (NOX4, MTCH1, GABARAPL2, and SLC2A3 ) and shown to accurately predict GC and H. pylori -associated GC. The FRGPI based on the hub genes could independently predict GC patient survival; GC patients in the high-risk group had considerably worse overall survival than did those in the low-risk group. The FRGPI was a significant predictor of GC prognosis and was strongly correlated with disease progression. Moreover, the gene expression levels of common immune checkpoint proteins dramatically increased in the high-risk subgroup of the FRGPI cohort. The hub genes were also confirmed to be highly overexpressed in GC cell lines and tissues and were found to be primarily localized at the cell membrane. The ferroptosis inducer FIN56 inhibited GC cell proliferation in a dose-dependent manner.

CONCLUSION

In this study, we developed a predictive model based on four FRGs that can accurately predict the prognosis of GC patients and the efficacy of immunotherapy in this population.
Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway
Authors: Wan Xiang-Hui , Jin Guo-Bing , Yang Qun , Hu Ji-Long , Liu Zhi-Liang , Rao Jun , Wen Can , Li Peng-Ling , Yang Xi-Mei , Huang Bo , Wang Xiao-Zhong
Published: May 2024

BACKGROUND

Heterogeneous ribonucleoprotein A1 (hnRNPA1) has been reported to enhance the Warburg effect and promote colon cancer (CC) cell proliferation, but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been elucidated.

AIM

To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT pathway.

METHODS

Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of hnRNPA1-b. The relationship between the expression values and the clinicopathological features of the patients was investigated. Differences in mRNA expression were analyzed using quantitative real-time polymerase chain reaction, while differences in protein expression were analyzed using western blot. Cell proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays, and cell cycle and apoptosis were detected using flow cytometric assays. The targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter assay. The Warburg effect was evaluated by glucose uptake and lactic acid production assays.

RESULTS

The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls (P < 0.05). Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC, including stage I, II-III, and IV. Furthermore, the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T classification. HnRNPA1-b was found to enhance the Warburg effect through the PI3K/AKT pathway, thereby promoting proliferation of HCT116 and SW620 cells. However, the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b, effectively blocking the Warburg effect.

CONCLUSION

These findings suggest that the novel miR-490-3p/hnRNPA1-b/PKM2 axis could provide a new strategy for the diagnosis and treatment of CC.
Mapping the intellectual structure and emerging trends for the application of nanomaterials in gastric cancer: A bibliometric study
Authors: Liu Bo-Na , Gao Xiao-Li , Piao Ying
Published: May 2024

BACKGROUND

Recent reviews have outlined the main nanomaterials used in relation to gastrointestinal tumors and described the basic properties of these materials. However, the research hotspots and trends in the application of nanomaterials in gastric cancer (GC) remain obscure.

AIM

To demonstrate the knowledge structure and evolutionary trends of research into the application of nanomaterials in GC.

METHODS

Publications related to the application of nanomaterials in GC were retrieved from the Web of Science Core Collection for this systematic review and bibliometric study. VOSviewer and CiteSpace were used for bibliometric and visualization analyses.

RESULTS

From 2000 to 2022, the application of nanomaterials in GC developed rapidly. The keyword co-occurrence analysis showed that the related research topics were divided into three clusters: (1) The application of nanomaterials in GC treatment; (2) The application and toxicity of nanomaterials in GC diagnosis; and (3) The effects of nanomaterials on the biological behavior of GC cells. Complexes, silver nanoparticles, and green synthesis are the latest high-frequency keywords that represent promising future research directions.

CONCLUSION

The application of nanomaterials in GC diagnosis and treatment and the mechanisms of their effects on GC cells have been major themes in this field over the past 23 years.
Undifferentiated high-grade pleomorphic sarcoma of the common bile duct: A case report and review of literature
Authors: Zheng Li-Ping , Shen Wen-Yan , Hu Chun-Dong , Wang Chun-Hua , Chen Xu-Jian , Wang Jing , Shen Yi-Yu
Published: May 2024

BACKGROUND

Undifferentiated pleomorphic sarcoma (UPS) is a rare malignant mesenchymal tumor with a poor prognosis. It mainly occurs in the extremities, trunk, head and neck, and retroperitoneum regions. Owing to the lack of specific clinical manifestations and imaging features, UPS diagnosis mainly depends on pathological and immunohistochemical examinations for exclusive diagnosis. Here we report an extremely rare case of high-grade UPS in the common bile duct (CBD). There are limited available data on such cases.

CASE SUMMARY

A 70-year-old woman was admitted to our department with yellow eyes and urine accompanied by upper abdominal distending pain for 2 wk. Her laboratory data suggested significantly elevated hepatorenal function levels. The imaging data revealed calculous cholecystitis, intrahepatic and extrahepatic bile duct dilation with extrahepatic bile duct calculi, and a space-occupying lesion at the distal CBD. After endoscopic biliary stenting and symptomatic support therapy, CBD exploration and biopsy were performed. The frozen section indicated malignant spindle cell tumor of the CBD mass, and further radical pancreaticoduodenectomy was performed. Finally, the neoplasm was diagnosed as a high-grade UPS combined with the light-microscopic morphology and immunohistochemical results.

CONCLUSION

This extremely rare case highlighted the need for increasing physicians' vigilance, reducing the odds of misdiagnosis, and providing appropriate treatment strategies.
Dimethyl Ether Biogas Reactivity-Controlled Compression Ignition for
Sustainable Power Generation with Low Nitrogen Oxide Emissions
Authors: Gopa Kumar S. , Mohan Aneesh , Ramesh A.
Published: May 2024

Biogas (60% methane–40% CO2 approximately) can be used in the
reactivity-controlled compression ignition (RCCI) mode along with a
high-reactivity fuel (HRF). In this work dimethyl ether (DME) that can also be
produced from renewable sources was used as the HRF as a move toward sustainable
power generation. The two-cylinder turbocharged diesel engine modified to work
in the DME–biogas RCCI (DMB-RCCI) mode was studied under different proportions
of methane (45–95%) in biogas since the quality of this fuel can vary depending
on the feedstock and production method. Only a narrow range of biogas to DME
ratios could be tolerated in this mode at each output without misfire or knock.
Detailed experiments were conducted at brake mean effective pressures (BMEPs) of
3 and 5 bar at a speed of 1500 rpm and comparisons were made with the
diesel–biogas dual-fuel and diesel–biogas RCCI modes under similar methane flow
rates while the proportion of CO2 was varied. The DMB-RCCI mode
exhibited superior brake thermal efficiency (25.3% as against 22% and 31.5% as
against 29% at the BMEPs of 3 and 5 bar) as compared to the other modes and was
not sensitive to the concentration of methane. The NOx and soot emissions were
also negligible and the lowest CH4 emission levels were also
attained. The cyclic fluctuations in IMEP were lower than 5% in this mode. Thus,
DME can be used along with biogas to enhance its reactivity for sustainable
power generation in the RCCI mode.
Effects of Hard-to-Measure Material Parameters on Clinching Joint
Geometries Using Combined Finite Element Method and Machine
Learning
Authors: Nguyen Duc Vinh , Tran Van-Xuan , Lin Pai-Chen , Nguyen Minh Chien , Wu Yan-Jiu
Published: May 2024

In this article, we investigated the effects of material parameters on the
clinching joint geometry using finite element model (FEM) simulation and machine
learning-based metamodels. The FEM described in this study was first developed
to reproduce the shape of clinching joints between two AA5052 aluminum alloy
sheets. Neural network metamodels were then used to investigate the relation
between material parameters and joint geometry as predicted by FEM. By
interpreting the data-driven metamodels using explainable machine learning
techniques, the effects of the hard-to-measure material parameters during the
clinching are studied. It is demonstrated that the friction between the two
metal sheets and the flow stress of the material at high (up to 100%) plastic
strain are the most influential factors on the interlock and the neck thickness
of the clinching joints. However, their dependence on the material parameters is
found to be opposite. First, while the friction between the two metal sheets
promotes the formation of the interlock, it reduces the neck thickness and thus
increases the risk of breaking in this region. Second, it is easier to form the
interlock if the deformed material exhibits small flow stress at high plastic
strain, but the neck thickness tends to be thinner in this case. The identified
material parameters help to significantly reduce the relative error between the
simulated results and the experimental results, not only in the configurations
from which they are identified but also in a new configuration. This methodology
shows its potential in the cases where material parameters are not available or
difficult to measure.
Fantasia (1940)
Authors: Uher Valerie
Published: May 2024

Fantasia is an animated American film produced by Walt Disney. The film consists of eight animated segments, of which ‘The Sorcerer’s Apprentice’ is the most famous one. Apart from ‘The Sorcerer’s Apprentice,’ all segments of the film are set to the music of well-known Western classical composers, performed by the Philadelphia Orchestra and conducted by Leopold Stokowski. Live action introductions by composer and music critic Deems Taylor link each segment. Fantasia was the first film to utilise stereophonic sound, referred to by Disney as ‘Fantasound’. In bringing together high art (classical music) with popular culture (animation), Fantasia demonstrates the modernist tendency to disregard cultural hierarchy and traditional distinctions between genres – an act that stirred controversy when the film was first released. The film employs an eclectic approach, splicing together pieces of music from longer symphonies and depicting heterogeneous subject matter, from characters based on Greek mythology to a literalistic portrayal of the extinction of the dinosaurs. The style of the animation, characterised by intricate multilayered images produced by multiplane cameras, draws from diverse modernist sources. The influence of surrealism, art-deco, modernist abstraction, combined with the more traditional influences of Romantic nineteenth-century painting and academic art, are all evident in its visual imagery. Both critically praised and widely popular, Fantasia was named number 5 in the American Film Institute’s top 10 best animated films, and number 58 in their list of the 100 best American films.
Film Noir
Authors: Dillon Mike
Published: May 2024

Hollywood of the 1940s and 1950s saw the emergence of ‘film noir’, a cycle of fatalistic crime thrillers, often produced as ‘B’ movies and distinguished by their narrative experimentation, expressive visual design, and stylized dialogue. Noir cemented the now-familiar archetypes of private detectives and femme fatales as well as techniques like flashbacks and first-person narration. Noir’s roots are wide-ranging, including hardboiled American crime fiction and cinematic movements like French Poetic Realism, Italian Neorealism, and German Expressionism. In subsequent decades, new generations of ‘neo-noir’ filmmakers would approach these conventions self-consciously, signalling a deliberate retooling (or even subversion) of the classical moulds. Today, neo-noir is visible across a variety of genres, such as science fiction and superhero films, and features in the works of numerous acclaimed filmmakers.
Horváth, Ödön von (Edmund Josef von Horváth) (1901–1938)
Authors: Ehrenreich Andreas
Published: May 2024

Born in Fiume to an aristocratic family, Horváth went to school in Budapest and Vienna and studied German literature and theatre in Munich. He left university, without graduating, to pursue the career of a writer. After an intense period of literary production in the second half of the 1920s, he received the prestigious Kleist Prize in 1931. His socio-critical plays became exceptionally popular as their author proved to be a keen observer of the economic crisis that tragically altered the life of the middle and working classes. Although his work displayed leftist tendencies, Horváth had an ambivalent attitude towards National Socialism. While his books were officially banned, he took advantage of his Hungarian nationality to work in the Fascist film industry. An extended series of ill success drove the playwright to emigration. He was not able to realize this plan as he died in a tragic accident at the Champs Elysées in Paris.
Bahraini Teachers’ Perceptions on the Challenges of Remote Teaching for Autistic Children
Authors: Daghustani Wid Hussain , MacKenzie Alison
Published: May 2024

This research aims to understand how teachers of autistic children responded to teaching remotely during the COVID-19 pandemic. Six teachers who work in an autism centre took part in face-to-face semi-structured interviews in the Kingdom of Bahrain on their perspectives of teaching autistic children remotely and how their mothers adapted to this mode of teaching. The teachers reported that the unprecedented change was challenging for autistic children and their families, but especially for mothers, who were in all cases, the primary caretakers. The effectiveness of remote teaching depended on the cooperation and the willingness of the mother and child to engage in the process. Overall, teachers agreed that in comparison to face-to-face teaching, remote teaching was not a positive experience.
Ozonización hídrica en la Campiña de Moche: Una propuesta científica para el reúso doméstico y el desarrollo Sostenible
Authors: Moya Egoavil Carlos , Hashimoto Ávila Karen
Published: May 2024

El estudio preliminar se llevó a cabo para evaluar la eficiencia del ozono en el tratamiento del agua del río Moche, ubicado a 27 m s.n.m. en la ciudad de Trujillo-La Libertad, Perú, con el fin de su posible reúso para riego agrícola y diferentes actividades domésticas. Se extrajo el agua siguiendo las recomendaciones de la EPA y se caracterizó antes y después del tratamiento con un generador de ozono, ECO-HE-145A, administrando 0.5 mg/L de gas O3 durante 5 a 25 minutos, según las normas internacionales ISO 3165 y 22637. Se evaluaron varios parámetros, como conductividad (EC), temperatura (T), sólidos disueltos totales (TDS), potencial de hidrógeno (PH) y oxidación-reducción (ORP), tanto con y sin inyección de ozono, en cumplimiento con las normativas locales DS N° 007-2019 y RM N° 256-2022-MINAM.El análisis estadístico de las variables TDS, Ph, EC y ORP mostró una reducción del 16 al 24% de los parámetros con la exposición al ozono durante diferentes periodos de tiempo. Estos resultados, en línea con los estándares de calidad del agua y las recomendaciones nacionales e internacionales, sugieren la viabilidad del tratamiento del agua del río Moche para reúso doméstico, lo que podría contribuir al desarrollo sostenible de la región La Libertad y abrir nuevas oportunidades para investigaciones futuras.
Primeiro Paciente Acolhido Pelo Centro De Cuidados Paliativos Jesuína Rosa Silva - Relato De Caso
Authors: Rodrigues Aguiar de Carvalho Jaqueline , Donato Bauman Claudiana , Toneli da Silva Wilian , Bernardina Miranda Soares Príscila , Silvana de Oliveira e Silva Carla , Dias Xavier Mariza
Published: May 2024

Objetivo: Relatar o caso do primeiro paciente acolhido no Centro de Cuidados Paliativos Jesuína Rosa Silva. Método: Abordagem observacional, realizada por meio de uma pesquisa descritiva e relato de caso clínico realizado mediante análise de prontuário e relatórios de atendimentos diários multidisciplinares, no Centro de Cuidados Paliativos Jesuína Rosa Silva, no ano de 2022, por meio amostra aleatória e não probabilística. Discussão: Ressalta-se que, quando se trata do cuidado em fim de vida, é fundamental que haja empatia e uma comunicação assertiva favorecendo o conforto e dignidade do paciente e da família diante um adoecimento que ameace a continuidade da vida. Considerações finais: A assistência humanizada de uma equipe multiprofissional, direcionada na condução do tratamento e acolhimento do paciente assistido no Centro de Cuidados Paliativos Jesuína Rosa Silva, demonstrou que, mesmo diante da iminência da morte, valores e princípios destacam-se na promoção do resgate da dignidade e qualidade de fim de vida do ser humano.
Control y castigo entre crisis, revolución y guerra. Una aproximación a las autoridades de policía en la ciudad de Buenos Aires y de México a inicios del siglo XIX
Authors: Vacaroni Maria Agustina
Published: May 2024

La crisis monárquica cuestionó el orden jurídico y social vigente; como consecuencia, se involucraron formas diversas de autoridad configuradas entre nociones y prácticas antiguas y nuevas; como los casos de la Superintendencia de Policía establecida en Ciudad de México en 1811 y la Intendencia de Policía creada en 1812 en Buenos Aires. Esta propuesta reconstruye la trama de normativas, agentes, funciones y prácticas policiales en el contexto de revolución y guerra abierto entre 1808-1810. Tras analizar estas instituciones, mostramos a los sujetos objeto de vigilancia; prestando particular atención a los vínculos entre las autoridades de policía y la gestión del castigo, explorando un vínculo no abordado en la historiografía disponible sobre la temática. Desde fuentes editas e inéditas conservadas en los archivos mexicanos y argentinos, ensayamos una mirada conjunta de dos espacios del imperio español, en la que una matriz común de policía fue reactualizada en una situación de excepcionalidad
Hubungan Pengetahuan Kepala Keluarga Dengan Perilaku Pencegahan Malaria Kampung Sakartemin
Authors: Weripang Imelda , Marti Eva , Ratnawati Emmelia
Published: May 2024

Pendahuluan : Penyakit Malaria disebabkan oleh parasite plasmodium pada nyamuk betina yang terinfeksi dan menginfeksi manusia, dengan gejala panas dingin, menggigil serta demam berkepanjangan. Gejala Malaria biasanya muncul 10-15 hari setelah parasit masuk ke tubuh manusia. Penyakit Malaria disebabkan oleh pengaruh perilaku, gaya hidup dan lingkungan yang tidak sehat. Salah satu faktor yang mempengaruhi perilaku manusia ialah tingkat pengetahuan. Tujuan dari penelitian ini untuk mengetahui apakah ada hubungan antara pengetahuan dengan perilaku pencegahan malaria didesa sakartemen distrik fakfak tengah kabupaten fakfak papua barat. Metode : Desain penelitian deskriptif kuantitatif , jenis metode korelasi cross sectional, sampel dalam penelitian 97 responden. Alat ukur yang digunakan merupakan lembar kuisioner pengetahuan dan kuisioner perilaku pencegahan malaria yang diberikan kepada responden. Hasil : Tingkat pengetahuan baik sebanyak 64 responden dan pengetahuan cukup 26 responden dan tingkat perilaku pencegahan malaria kurang baik 66 responden dan perilaku pencegahan malaria baik 31 responden. Angka koefisien korelasi nilai r = 0,442 (korelasi lemah) dan p value = 0.000 (signifikan) berhubungan. Kesimpulan : Terdapat hubungan yang signifikan antara pengetahuan dengan perilaku pencegahan malaria dengan kekuatan korelasi lemah. Penelitian berikutnya disarankan  mengambil studi kualitatif terkait faktor yang mempengaruhi perilaku kepala keluarga dalam pencegahan malaria.
Kata kunci : pengetahuan,perilaku pencegahan, penyakit malaria,faktor yang mempengaruhi perilaku.
Probiotics and Synbiotics as Potential Biotics in Gut Health-Promoting Nutrition
Authors: Stephanie Kartjito Melissa , Faisal Umam Aldo
Published: May 2024

Disorders of gut health can impact a variety of health problems, including the digestive system, immunity, and even mental health. The aim of this study was to investigate the potential of probiotics and synbiotics as potential biotics in nutrition to improve gut health. This study used qualitative research methods. The data collection technique for this is literature study. The data that has been collected is then analyzed in three stages, namely data reduction, data presentation and drawing conclusions. The research results show that probiotics and synbiotics are potential biotics in nutrition that can improve intestinal health. Probiotics and synbiotics can help modulate the composition of the body's beneficial microbiota. In addition, it can help reduce levels of pathogenic bacteria and help reduce persistent inflation of the intestines, which can improve the balance of the body's beneficial microbiota
Pro dan Kontra Penafsiran Hukum Islam Terhadap Tradisi Peringatan Ritual Kematian Masyarakat Jawa
Authors: Rohmani Annas Fajar , Hidayat Syamsul
Published: May 2024

Persoalan tentang kematian, merupakan hal yang rumit untuk dimaknai. Karena makna dari kematian itu bergantung bagaimana sudut pandang seseorang yang didapatkan selama hidup didunia. Kematian dalam berbagai daerah selalu diirngi dengan proses ritualisasi, alasan disebut sebagai rituaisasi adalah pandangan bahwa jika manusia mengalami kematian,bukan berarti ia telah lenyap atau sudah berakhir dalam kehidupan. Tujuan penulisan dalam artikel ini yaitu untuk mengungkapkan pandangan dari dua kelompok yang setuju dan tidak setuju dengan adanya ritual kematian yang masih berkembang dalam masyarakat jawa. Metode yang digunakan dalam penelitian ini yaitu literature review, dengan melakukan identifikasi, evaluasi, dan interpretasi terhadap beberapa penelitian yang relevan. Hasil dari penelitian ini menyatakan bahwa kelompok yang setuju dengan tradisi ritual kematian dilandasi oleh beberapa pandangan diantaranya tahlilan merupakan ajaran Islam yang dibawa dari Timur Tengah, acara tahlilan ada dalam sebuah hadist dan dipraktikkan pada masa Rasulullah, pemberi makan pada upacara selamatan dianggap sebagai sedekah. Kelompok kontra memandang upacara ritual kematian merupakan pemborosan dan dianggap membebani orang yang ditinggalkan. Acara tahlilan bukan upaya untuk mengirimkan pahala kepada mati, namun seseorang mendapatkan pahala selama apa yang telah mereka usahakan didunia selama hidup. Dalam ritual kematian juga menyajikan sesaji sebagai sesambahan kepada leluhur.
Penggunaan Google Earth dalam Pembelajaran IPS
Authors: Ali Muhamad Khaedar , Kamal Astrid Liani , Safitri Desy , Sujarwo Sujarwo
Published: May 2024

Pemanfaatan teknologi informasi dan komunikasi telah memberikan dampak yang signifikan terhadap dunia pendidikan, khususnya  pembelajaran Ilmu Pengetahuan Sosial (IPS). Salah satu teknologi yang merevolusi pembelajaran ilmu sosial adalah Google Earth. Google Earth adalah  aplikasi berbasis web yang  menggabungkan citra satelit, peta, dan foto udara ke dalam  platform interaktif untuk memberikan visualisasi tiga dimensi permukaan bumi. Penelitian ini bertujuan untuk mengkaji pemanfaatan Google Earth dalam pembelajaran IPS. Metode yang digunakan adalah tinjauan literatur dan analisis kualitatif  studi kasus penggunaan Google Earth dalam berbagai konteks pembelajaran IPS.Studi ini menunjukkan bahwa Google Earth menawarkan berbagai keunggulan dalam pembelajaran ilmu sosial, antara lain visualisasi  fenomena geografis dan sosial yang realistis, eksplorasi interaktif tempat sejarah dan budaya, serta analisis sebaran dan pola geografis. Selain itu, Google Earth memungkinkan Anda dengan mudah memasukkan konsep geografis dan sosial ke dalam pelajaran IPS, meningkatkan keterlibatan dan minat siswa melalui pengalaman belajar yang menarik dan interaktif. Namun, penelitian ini juga menyoroti beberapa tantangan dalam menggunakan Google Earth, termasuk keterbatasan aksesibilitas dan infrastruktur, serta perlunya pelatihan dan dukungan bagi guru untuk mengintegrasikan teknologi ini ke dalam kelas mereka. Oleh karena itu, penggunaan Google Earth dalam pendidikan ilmu sosial menjanjikan potensi besar dalam meningkatkan pemahaman siswa terhadap fenomena geografis dan sosial serta mengembangkan keterampilan analitis dan berpikir kritis. Namun, memaksimalkan manfaat teknologi ini untuk pembelajaran ilmu-ilmu sosial yang efektif dan berkelanjutan memerlukan upaya kolaboratif antara pendidik, pengembang teknologi, dan pemangku kepentingan lainnya.
Analisis Pengambilan Keputusan dengan Kebijakan Rumah Belajar untuk Meningkatkan Kualitas Pendidikan di Dusun Kepyar, Kecamatan Purwantoro, Wonogiri
Authors: Romadhon Akbar , Bagus Rizky , Jamal Adam
Published: May 2024

Pendidikan adalah salah satu bagian terpenting yang harus diperhatikan oleh pemerintah, baik pemerintah pusat, pemerintah provinsi, maupun pemerintah daerah. Pendidikan yang unggul dan berkembang merupakan sebuah pengaruh untuk kualitas kehidupan berbangsa. Tujuan dari pendidikan itu adalah sebuah proses penangkapan ilmu dari yang dasar dan ranah ilmu yang kompleks. Sebagaimana kita ketahui, segala kebijakan yang pemerintah programkan untuk menopang kualitas pendidikan tidak selalu berjalan dengan maksimal. Tantangan dan hambatan sering dijumpai dalam proses pengembannya. Ada beberapa faktor yang mempengaruhi pendistribusian program pendidikan tersebut, diantaranya adalah kondisi geografis, budaya, dan sumber daya manusia. Tidak sedikit daerah dengan kondisi geografis yang sulit diakses mengalami ketertinggalan baik dari segi kualitas pendidikan maupun sarana dan prasarana yang memadai. Tak terkecuali Dusun Kepyar, Desa Kepyar, Kecamatan Purwantoro yang terletak di Kabupaten Wonogiri bagian Timur. Lokasi daerah yang berada di bawah kaki gunung menyebabkan jarak dari lokasi pelajar menuju tempat sekolah menjadi jauh. Hal tersebut menjadi perhatian lembaga kepedulian untuk mengambil alternatif dengan mendirikan rumah belajar. Dengan demikian tujuan dari penulisan ini ialah untuk mengidentifikasi bagaimana proses pengambilan keputusan tersebut bisa diimplementasikan.
The Influence of Human Resource Competence, Implementation of Agency Level Financial Application Systems and Organizational Commitment on The Information Value of Central Government Financial Reports (Empirical Study in The Ministry of Industry in Java and Sumatera Regions)
Authors:   Faculty of Economic and Business, University of North Sumatera, Pramita Soraya , Muda Iskandar ,   Faculty of Economic and Business, University of North Sumatera, Yahya Idhar ,   Faculty of Economic and Business, University of North Sumatera
Published: May 2024

This study aims to determine, test, and analyze the influence of human resource competence, implementation of agency-level financial application systems, and organizational commitment on the information value of central government financial reports in the ministries of industry in the Java and Sumatera regions. This research uses quantitative methods with an associative approach and documentary data collection by collecting, recording, reviewing and analyzing primary data in the form of respondents’ answers to the questionnaires given. This research took 70 samples as respondents from work units. The data analysis technique used is descriptive statistics which is used to explain the data description of all variables and Partial Least Square (PLS) regression analysis which is a Structural Equation Model (SEM) equation model. The results of this research show that human resource competence, application system implementation agency level finance, and organizational commitment influence the information value of central government financial reports.
Effect of Goat Dung, Saboak and Corn Cobs Charcoal Mixture on the Physicochemical Properties of Biochar Briquettes
Authors:   Faculty of Animal Science, Marine and Fisheries Universitas Nusa Cendana Adisucipto Street Penfui, Kupang, East Nusa Tenggara, 85001, Matheos Prabo Robert , Rosnah Upik S. ,   Faculty of Animal Science, Marine and Fisheries Universitas Nusa Cendana Adisucipto Street Penfui, Kupang, East Nusa Tenggara, 85001, R. Noach Yakob ,   Faculty of Animal Science, Marine and Fisheries Universitas Nusa Cendana Adisucipto Street Penfui, Kupang, East Nusa Tenggara, 85001, Dato T.O. Dami ,   Faculty of Animal Science, Marine and Fisheries Universitas Nusa Cendana Adisucipto Street Penfui, Kupang, East Nusa Tenggara, 85001
Published: May 2024

The experiment goals to investigate the physicochemical properties of biochar briquette mixed of goat dung, saboak shell and corn cob charcoal. Research used a completely randomized design with 4 different treatments were: P1 = 25% of goat dung + 75% saboak shell charcoal; P2 = 25% of goat dung + 50% saboak shell + 25% corn cob charcoal; P3 = 25% of goat dung + 25% saboak shell + 50% corn cobs charcoal; P4 =25% of goat dung + 75% corn cobs charcoal. Variables measured included yield, density, moisture, ash, calorific value, volatille matter and fixed carbon. Data were analyzed according to the statistic analysis procedure. The mean values obtained were yield 57.54%; density 0.62 g/cm3; moisture 4.67%; ash 16.93%; calorific value 5198.75 cal/g; volatile matter 25.18%; fixed carbon 53.23%. The results of variance analysis showed that the treatment had a very significant effect (P<0.01) on density and calorific value but not significant (P>0.05) on yield, moisture, ash, volatile matter and fixed carbon. It can be concluded that using of corn cobs as substitute of saboak shell ini briquettes making blend of goat manure can be improve the calorific value, with similar ini yield, moisture, ash, volatile matter and fixed carbon. The best characteristic of briquettes find out in mixing of 25% goat manure + 25% saboak shell + 50% corn cobs.
Development of Google Sites-Based Social Science Learning Media to Increase Students’ Critical Thinking Ability
Authors:   Faculty of Economics and Business, Yogyakarta State University, Yogyakarta, Indonesia, Aziza Aini , Baroroh Kiromim ,   Faculty of Economics and Business, Yogyakarta State University, Yogyakarta, Indonesia
Published: May 2024

This research aims to (1) produce social studies learning media based on google sites to improve critical thinking skills of junior high school students grade VIII (2) determine the feasibility level of social studies learning media based on google sites to improve critical thinking skills of junior high school students grade VIII (3) determine the level of practicality of social studies learning media based on google sites to improve critical thinking skills of junior high school students grade VIII (4) determine the effectiveness of social studies learning media based on google sites to improve critical thinking skills of junior high school students grade VIII. This development research uses the ADDIE development model which stands for the stages of development, namely: Analysis, Design, Development, Implementation, and Evaluation. The subjects of this study were SMPN 5 Banjit students totaling 60 divided into 2 groups, namely the experimental group and the control group. In this study, data were obtained using test and non-test techniques. The test technique was used to obtain data on the effectiveness of the product which was carried out using a student critical thinking ability test instrument. While the non-test technique was used to collect data on the validity and practicality of the product which was carried out using product validation sheets, material validation sheets, teacher assessment sheets, and student assessment sheets. The results of this study indicate that the socialexplore website has very high feasibility. The results of material expert validation amounted to 3.79 with a decent category. The results of media validation amounted to 4.44 with a very feasible category. Teacher validation results of 4.40 with a very practical category. The results of user validation amounted to 4.31 with a very practical category. The results also show that the socialexplore website is effective and can help students to improve students' critical thinking skills on the material of the diversity of Indonesian society. The results of the experimental class critical thinking ability test were higher than the control class with an average value of 69.43 and the control class average value of 47.93. The Gain test results of the experimental class at SMPN 5 Banjit amounted to 0.68 with a moderate category.
Influence of Human Resource Management on Work Performance at Vietnam Higher Education Institutions
Authors:   PhD student at the University of Economics and Business, Vietnam National University, Hanoi, Vietnam, Pham Vuong
Published: May 2024

The purpose of the paper is to examine the impact of human resource management on employee performance in Vietnam universities. In addition to empirically testing the hypotheses in the context of university autonomy in Vietnam, the research has attempted to further examine the achieved results and challenges for human resource management in Vietnam's higher education institutions through the variable regulating University autonomy. The findings in the research have provided empirical support for the correlation between human resource management and employee performance in higher education institutions. The author asked for the opinions of several experts on the questionnaire. Then send the test questionnaire to 10 agencies in higher education institutions. The author has adjusted the questionnaire to make it easier to understand to get the most accurate and reliable answers. The author sent the questionnaire during the period from April 2023 to June 2023, the total number of survey questionnaires distributed was 370 questionnaires, of which 350 votes are eligible for analysis.
PEMBINAAN IMAN ORANG MUDA KATOLIK DI PAROKI SANTA PERAWAN MARIA DIANGKAT KE SURGA KABANJAHE
Authors: Sitepu Abdi Guna , Lumbanbatu Johannes , Sinulingga Aldi Alfrianza , Sihotang Din Oloan
Published: May 2024

Orang muda Katolik (OMK) adalah kelompok individu yang lahir dan dibesarkan dalam tradisi Katolik. Rentang usia antara remaja hingga awal dewasa. Pada fase ini orang muda banyak mengalami krisis identitas dan iman. OMK saat ini menghadapi tantangan dan perubahan dalam dunia yang semakin kompleks dan dinamis. Faktor seperti globalisasi, teknologi, dan perubahan sosial memengaruhi pandangan mereka terhadap nilai-nilai iman mereka. Tujuan dari pengabdian ini adalah untuk memberikan pembinaan iman kepada OMK agar semakin memahami dan mencintai iman mereka. Kegiatan dilakukan dengan memberikan ceramah dan materi tentang iman Katolik. Pemberian materi juga diselingi dengan games, dinamika kelompok, lagu dan gerak, serta praktik ibadat. Metode yang dipakai dalam analisis hasil Pengabdian Kepada Masyarakat ini adalah metode kualitatif. Hasil yang diperoleh adalah melalui pengabdian yang telah dilaksanakan OMK semakin menambah pengetahuan dan pemahaman akan nilai-nilai iman Katolik.