bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined immunoinformatic approaches with computational biochemistry for development of subunit-based vaccine against Lawsonia intracellularis
Authors: Khatooni Zahed , Broderick Gordon , Anand Sanjeev K. , Wilson Heather L.
Published: February 2025

Lawsonia intracellularis (LI) are obligate intracellular bacteria and the causative agent of proliferative hemorrhagic enteropathy that significantly impacts the health of piglets and the profitability of the swine industry. In this study, we used immunoinformatic and computational methodologies such as homology modelling, molecular docking, molecular dynamic (MD) simulation, and free energy calculations in a novel three stage approach to identify strong T and B cell epitopes in the LI proteome. From ∼ 1342 LI proteins, we narrowed our focus to 256 proteins that were either not well-identified (unknown role) or were expressed at a higher frequency in pathogenic strains relative to non-pathogenic strains. At stage 1, these proteins were analyzed for predicted virulence, antigenicity, solubility, and probability of residing within a membrane. At stage 2, we used NetMHCPan4-1 to identify over ten thousand cytotoxic T lymphocyte epitopes (CTLEs) and 286 CTLEs were ranked as having high predicted binding affinity for the SLA-1 and SLA-2 complexes. At stage 3, we used homology modeling to predict the structures of the top ranked CTLEs and we subjected each of them to molecular docking analysis with SLA-1*0401 and SLA-2*0402. The top ranked 25 SLA–CTLE complexes were selected to be an input for subsequent MD simulations to fully investigate the atomic-level dynamics of proteins under the natural thermal fluctuation of water and thus potentially provide deep insight into the CTLE-SLA interaction. We also performed free energy evaluation by Molecular Mechanics/Poisson−Boltzmann Surface Area to predict epitope interactions and binding affinities to the SLA-1 and SLA-2. We identified the top five CTLEs having the strongest binding energy to the indicated SLAs (-305.6 kJ/mol, -219.5 kJ/mol, -214.8 kJ/mol, -139.5 kJ/mol and -92.6 kJ/mol, respectively.) W also performed B-cell epitope prediction and the top-ranked 5 CTLEs and 3 B-cell epitopes were organized into a multi-epitope subunit antigen vaccine construct joined using EAAAK, AAY, KK, and GGGGG linkers with 40 residues of the LI DnaK protein attached to the N-terminus to further enhance the antigenicity of the vaccine construct. Blind docking studies showed strong interactions between our vaccine construct with swine Toll-like receptor 5. Collectively, these molecular modeling and immunoinformatic analyses present a useful in silico protocol for the discovery of candidate antigen in many viral and bacterial pathogens.
Pathways to sustainability: Higher education and green productivity
Authors: Sun Yongchun
Published: February 2025

The research conducted theoretical analysis and empirical testing on the relationship between higher education and regional green productivity based on panel data from 30 Chinese provinces from 2003 to 2021. The study’s findings demonstrate that higher education can have a major impact on local green production. In order to determine whether industrial structure upgrading and the digital economy work together to promote the development of green productivity, higher education is added to these factors at the same time as the new economic growth mode transformation in the digital economy era. The research hypothesis aligns with the results, suggesting that higher education and the digital economy collaborate to enhance green productivity levels. Higher education has a more significant impact on green productivity the greater the level of regional economic growth, according to a further nonlinear test utilizing the partial linear function coefficient (PLFC) model. Higher education’s influence on green production varies by place and period, becoming more pronounced as time passes and the degree of regional economic growth rises. In order to fully utilize higher education’s capacity for scientific research, innovation, and talent, as well as to increase the direct contribution of its scientific and technological innovations to the advancement of national industry and production promotion, it is imperative that people actively promote the new type of industrialization, develop the digital economy, and work in tandem with higher education.
Adaptation to acidic conditions that mimic the tumor microenvironment, downregulates miR-193b-3p, and induces EMT via TGFβ2 in A549 cells
Authors: Higashi Sadayuki , Yamakuchi Munekazu , Hashinokuchi Hirohito , Takenouchi Kazunori , Tabaru Akito , Oyama Yoko , Fujisaki Chieko , Tanoue Kiyonori , Hashiguchi Teruto
Published: February 2025

The acidic tumor microenvironment plays a critical role in the malignant transformation of cancer cells. One mechanism underlying this transformation involves epithelial-mesenchymal transition (EMT). This is induced by prolonged exposure to acidic conditions. EMT is an essential process in cancer progression, with Transforming Growth Factor Beta (TGF-β) playing a central role in its induction. However, little was known about the factors regulating TGF-β under acidic conditions. This study aimed to elucidate the mechanism of EMT under acidic conditions and identify novel therapeutic targets to inhibit cancer cell migration and metastasis. Focusing on lung cancer, we explored microRNAs associated with EMT that were differentially expressed under acidic conditions in A549 cells and identified miR-193b-3p as a novel candidate. Under acidic conditions, miR-193b-3p expression decreased around days 3–14. Downregulation of miR-193b-3p promoted increased TGFβ2 expression, resulting in EMT changes in A549 cells. Our study suggests that the interaction between miR-193b-3p, TGFβ2, and the acidic tumor microenvironment promotes cancer EMT change. Understanding these interactions may not only enhance our biological comprehension of cancer, but also pave the way for the development of targeted therapies to inhibit cancer metastasis.
The link between impact-induced tensile strain and dendritic spine morphology in porcine brain tissue
Authors: Hoffe Brendan , Kang Gia , Thomson Hannah , Banton Rohan , Piehler Thuvan , Petel Oren E. , Holahan Matthew R.
Published: February 2025

Brain tissue as a material presents unique properties with a multitude of cell types and densities, varying degrees of axonal fiber diameters and blood vessels. These neural components are contained within a very viscous environment that upon impact, can result in a variety of tensile, compressive and rotational forces. The depths of the sulcus appear to be particularly vulnerable to biomechanical forces following an impact. The movement and subsequent forces loaded on to the brain have been shown to produce a variety of biomechanical responses that impair neurophysiological functioning at the cellular level. We recently reported a decrease in microtubule associated protein 2 (MAP2) within the depths of the porcine sulcus in an ex vivo model, along with elevated tensile strain in this region within 1 hour after impact. In the current work, using the same impact model, we explored whether changes in spine morphology and density occurred within the same timeframe following impact. The Golgi-Cox method was used to visualize dendritic spine morphology. Cortical pyramidal neurons within the depths and the arms of the sulcus were reconstructed. One hour after impact, there was a change in the distribution of spine type resulting in an increased proportion of mushroom-type spines compared to nonimpacted tissue. The increased proportion of mushroom-type spines was proportional to tensile strain measurements in the apical dendrites. These results demonstrate the sensitivity of dendritic spine morphology to tensile strain within the porcine cortex and suggest a state of hyperexcitability during the hyperacute phase following an impact.
Dreams Shared by Two Modern Poets in the 20th Century: T. S. Eliot’s Totemic-Mosaic Dream and Langston Hughes’s Dream Deferred
Authors:   The T. S. Eliot Society Of Korea, Kim Joseph Yosup
Published: February 2025

This paper compares and contrasts the portrayal of dreams in T. S. Eliot’s The Waste Land and Langston Hughes’s “Harlem (2).” Eliot’s totemic-mosaic dream reflects the disillusionment and division of modern society where dreams are broken and disconnected, symbolizing spiritual decay in the aftermath of World War I. Eliot presents a world in which the meaning is blurred and the possibility of renewal has disappeared through divided images and mythical hints. In contrast, Hughes’s “Harlem (2)” explores the consequences of deferred dreams, especially those of African Americans who crave equality and justice. Using vivid and concrete images, Hughes describes the emotional and social damage caused by unfulfilled aspirations, suggesting that deferred dreams should “dry up,” “fester,” or “explode.” Hughes presents a more dynamic and collective deferred hope that can eventually lead to social upheaval, while Eliot’s vision is about passive despair and spiritual collapse. In the end, this paper emphasizes the destructive power of dreams in which is achieved by neither poet. The author argues in this paper that Hughes’s dream is rooted in social context and potential for change, whereas Eliot’s dream reflects a wider existential crisis in a divided post-war world.
A Re-reading of “Gerontion” : Desire of Homodeus
Authors:   The T. S. Eliot Society Of Korea, LEE Kyu-myoung
Published: February 2025

Human actions in the face of marginal situations are limited to the practice of micro-libido, not the immanence that can influence the universe. However, it is obvious that the individual freewheeling movement of libido leads to social catastrophes. The elderly have been entrusted to die in accordance with the natural order, but they practice their desire to be internalised as a human god (homeodus) to break the natural order. As shown in the films Ireland (2005) and Minority Report (2002), the body is cultured into stem cells, and the brain's memory is transferred to the cloud of infinite capacity to dream of eternal life. Therefore, the elderly do not die, but face the origin of singularity that extends the life of regeneration. Therefore, human death that the poetic narrator is concerned about, disappears, and it will become a choice, not a natural inevitability. However, the problem is that it is time to enhance the weak mental value in proportion to the immortality of the body guaranteed by the artificial intelligence machine, and it is time to actively consider the effective public system for the elderly at a national level. In the era of regeneration that makes the disabled walk as Christ worked wonders, life for the elderly is not a sarcastic curse, but a bliss of rehabilitation. Therefore, the future life that will unfold to the “dry” old man waiting for the “rain” will be filled with the gospel of “Shanti shanti shanti” erasing fear and promising happiness.
On Chainsaws and Acoustic Violence: Sound and Deforestation in Ajusco-Chichinautzin, Mexico
Authors: Green Andrew
Published: February 2025

This article explores distinct practices of sounding and listening that have emerged in a context of severe deforestation in Ajusco-Chichinautzin, a region south of Mexico City. It applies the concept of acoustic violence to this setting, as part of wider attempts to build constructive responses to climate breakdown through sound and music scholarship. As the first indication of occurring logging, the sound of chainsaws proves vital in attempts by forest guards and police to detect and halt deforestation. Equally, attentiveness to acoustic violence allows us to cut through sensationalist media presentations of the problem of deforestation, to perceive how local populations—often blamed for complicity with loggers—are in fact direct victims of environmental loss. The concept of acoustic violence can also illuminate how, in a context not just of environmental loss but of dispossession, modalities of listening may become simplified, instrumentalized, or lost. 
RESUMEN
Este artículo explora distintas prácticas de sonar y escuchar que han surgido en un contexto de severa deforestación en Ajusco-Chichinautzin, una región al sur de la Ciudad de México. Aplica el concepto de violencia acústica a este contexto, como parte de intentos más amplios de construir respuestas constructivas al colapso climático a través de la investigación sonora y musical. Como primer indicio de la tala en curso, el sonido de las motosierras resulta vital en los intentos de los guardabosques y la policía por detectar y detener la deforestación. De igual modo, prestar atención a la violencia acústica nos permite trascender las presentaciones sensacionalistas de los medios de comunicación sobre el problema de la deforestación y percibir cómo las poblaciones locales, a menudo culpadas de complicidad con los taladores, son de hecho víctimas directas de la pérdida ambiental. El concepto de violencia acústica también puede iluminar cómo, en un contexto no sólo de pérdida ambiental sino de despojo, las modalidades de escucha pueden simplificarse, instrumentalizarse o perderse.
Religious Afterlives of a Revolution
Authors: Mittermaier Amira
Published: February 2025

When do revolutions end? How do revolutions live on in embodied affects, relationships, and horizons of aspiration? This article describes the remaking of religion among upper-middle-class Egyptians who participated in the 2011 uprising. It traces a widespread turn to Sufism, yoga, and meditation, along with the search for a personal connection to God. My interlocutors’ spiritual bricolage could easily be read as an effect of political defeat, neoliberal self-care, or part of a global trend of declaring oneself “spiritual-but-not-religious.” Yet such contextualizing moves fail to grasp the sense of newness, surprise, and experimentation that pervades my interlocutors’ narratives. I suggest that the revolution’s indeterminacy is kept alive through the ethos of experimentation. Post-revolutionary spiritual bricolage results in seemingly apolitical practices like Sufi yoga, but from these practices a revolutionary spark can re-emerge. 
ملخص
متى‭ ‬تنتهي‭ ‬الثورات؟‭ ‬وكيف‭ ‬تعيش‭ ‬الثورة‭ ‬بعد‭ ‬انتهائها‭ ‬وتستمر‭ ‬في‭ ‬المشاعر‭ ‬والأفكار‭ ‬والعلاقات‭ ‬والآفاق‭ ‬والأحلام؟ يصف‭ ‬هذا‭ ‬المقال‭ ‬إعادة‭ ‬تشكيل‭ ‬الدين‭ ‬بين‭ ‬المصريين‭ ‬من‭ ‬الطبقة‭ ‬المتوسطة‭ ‬العليا‭ ‬الذين‭ ‬شاركوا‭ ‬في‭ ‬ثورة‭ ‬52‭ ‬يناير‭. ‬يتتبع‭ ‬المقال‭ ‬التحول‭ ‬نحو‭ ‬الصوفية‭ ‬واليوغا‭ ‬والتأمل،‭ ‬إلى‭ ‬جانب‭ ‬السعي‭ ‬للبحث‭ ‬عن‭ ‬اتصال‭ ‬شخصي‭ ‬بالله‭. ‬يمكن‭ ‬تفسير‭ ‬هذا‭ ‬التحول‭ ‬نحو‭ ‬الروحانية‭ ‬بسهولة‭ ‬كنتيجة‭ ‬للهزيمة‭ ‬السياسية،‭ ‬أو‭ ‬كجزء‭ ‬من‭ ‬الفردانية‭ ‬النيوليبرالية،‭ ‬أو‭ ‬باعتباره‭ ‬جزءًا‭ ‬من‭ ‬الاتجاه‭ ‬العالمي‭ ‬المعروف‭ ‬بالانتماء‭ ‬إلى‭ ‬االروحانية‭ ‬ولكن‭ ‬غير‭ ‬الدينية‭ ‬اومع‭ ‬ذلك‭ ‬فإن‭ ‬التفسير‭ ‬من‭ ‬خلال‭ ‬هذا‭ ‬السياق‭ ‬قد‭ ‬يفشل‭ ‬في‭ ‬استيعاب‭ ‬روح‭ ‬المغامرة‭ ‬والمفاجأة‭ ‬والتجريب‭ ‬التي‭ ‬تبرز‭ ‬في‭ ‬روايات‭ ‬من‭ ‬حاورتهم‭. ‬يقترح‭ ‬هذا‭ ‬المقال‭ ‬أن‭ ‬روح‭ ‬الثورة‭ ‬التجريبية‭ ‬كانت‭ ‬حية‭ ‬في‭ ‬تلك‭ ‬التجارب،‭ ‬وأن‭ ‬روح‭ ‬التخبط‭ ‬والتجريب‭ ‬والإبداع‭ ‬ما‭ ‬بعد‭ ‬الثورات‭ ‬تنتج‭ ‬العديد‭ ‬من‭ ‬الممارسات‭ ‬غير‭ ‬المسيسة‭ ‬أو‭ ‬التي‭ ‬تتنافى‭ ‬مع‭ ‬الفعل‭ ‬السياسي،‭ ‬مثل‭ ‬اليوغا‭ ‬الصوفية‭ ‬وغيرها‭ ‬ولكن‭ ‬من‭ ‬بين‭ ‬هذه‭ ‬الممارسات‭ ‬قد‭ ‬تنبثق‭ ‬شرارة‭ ‬ثورية‭ ‬جديدة‭.‬‭ ‬
Isha’s Wait
Authors: Jaju Garima
Published: February 2025

Isha waits in her low-income parents’ home for her estranged husband, charged for dowry and domestic violence, to pay her the legally mandated maintenance money. I listen to her as she talks about pyaar, or love, and domestic violence as arising from the absence of its ehsaas, or feeling/realization, by the abusive husband. The awaited money is infused with the hopeful imagination that it will generate both pyaar and its ehsaas. I argue that money becomes a substance of kinship assigned an agentive role in engendering the ethical transformation of a “bad” husband to create “good” kinship. Exploring the ways in which the tenuous legal promise of money sustains imaginations of reformed kinship futures, I outline how centrally money shapes the experience of domestic violence and its aftermath.
Double emulsions based on fish oil in composition with fucoidan: useful profile
Authors:   South Ural State University, Bagale Uday , Kadi Ammar ,   South Ural State University, Potoroko Irina ,   South Ural State University, Kalinina Irina ,   South Ural State University, Malinin Artem ,   South Ural State University, Tsaturov Aram ,   South Ural State University
Published: February 2025

The creation of food systems in a new format allows for targeted delivery of biologically active substances, influencing the preservation of organoleptic properties and increasing bioavailability and bioactivity. One of the new format systems is double emulsions. The purpose of this work is to use the cavitation effects of ultrasound to encapsulate sulfated fucoidan heteropolysaccharide into a first level W1 (H2O:BAS)/O emulsion derived from fish oil for placement in a double emulsion system. To achieve this goal, samples of the first-level emulsion were obtained with the inclusion of a bioactive substance (BAS) of brown algae, fucoidan, in an amount of 5–10 mg and without the addition of BAS, stabilized by a plant sur-factant. The utility profile of the resulting emulsions was assessed based on a set of experi-mental studies. The results of the study showed that optimal combinations of biologically active substances and fat fractions were identified in sample 2 when encapsulating fucoidan in an amount of 10 mg in the first level of a double emulsion based on fish oil. An increase in antioxidant activity was observed. The results of FT-IR spectroscopy of the studied samples of first-level emulsions showed that the band at 1743 cm–1 represents a stretching vibration of aldehyde or ester carbonyl groups (C=O) and may reflect the degree of unsaturation. A peak is also observed at 3010 cm–1, which indicates the concentration of ω3 FA-PUFAs, including docosahexaenoic acid (DHA) and eicosatetraenoic acid (EPA). These fatty acids play a key role in maintaining the health of the human heart, brain, and eyes. Therefore, we can say with confidence that first-level emulsions created on the basis of fish oil in composition with fucoidan will be effective as part of double emulsions for the enrichment of various food systems.
POLICY IMPLEMENTATION OF THE NATIONAL ACTION PLAN FOR THE PREVENTION, ERADICATION, ABUSE AND ILLICIT DRUG TRAFFICKING (P4GN): TOWARDS STRENGTHENING NATIONAL RESILIENCE
Authors: Dinansi Clarissa Ivana Kartika
Published: February 2025

The high level of drug abuse that threatens social stability and national security is the background of this research. The urgency of the research lies in the need for cross-sector policy synergy to effectively tackle drug trafficking. This research aims to analyze the implementation of the prevention, eradication, abuse and illicit drug trafficking (P4GN) policy. This research uses a qualitative method with a descriptive-analytical approach, combining literature studies and in-depth interviews with relevant policy stakeholders. The results show positive impacts of the policy such as increased public awareness through the Drug Information Education Center (PIE), although there are still obstacles such as weak coordination between agencies and limited resources. Law enforcement by BNN and Polri shows significant progress, but needs to be balanced with strengthening rehabilitation programs for addicts. Implementation of this policy requires periodic evaluation, development of anti-drug module-based education, and community empowerment to strengthen overall national resilience.
Ecology, distribution mapping and population structure of Trichopus zeylanicus subsp. travancoricus (Arogyapacha)
Authors: Angala M , Anto M , Anilkumar C
Published: February 2025

Trichopus zeylanicus subsp. travancoricus (Bedd.) Burkill ex K. Narayanan (Arogyapacha) is an ethnomedically important perennial herb with a restricted distribution in the southern Western Ghats, India. Habitat specifications reveal that suitable areas for this species occur at elevations ranging from 100 to 1000 m above sea level. A study was conducted to gain insights into the ecology, distribution mapping and population structure of T. zeylanicus subsp. travancoricus in the Western Ghats. The spatial distribution of this endemic species showed significant variations among populations. Seven populations were identified, exhibiting large and small distributional patches, even within a single population. Anthropogenic activities and climate-related shifts in ecophysiology have impacted seed dispersal, canopy gap formation and seedling mortality, altering vegetation composition. Observations indicated a disturbed ecological niche, fragmented habitat and patchy occurrence of this species. The vegetation data for T. zeylanicus subsp. travancoricus showed significant variations among the seven populations. The Kulathupuzha population exhibited higher recruitment rates and density than others. Canopy cover analysis revealed that populations with closed canopies influenced seedling recruitment and density. However, populations with moderately closed canopies displayed variable characteristics, with Kulathupuzha standing out for its higher recruitment rate and reproductive capacity.
Simpson, midpoint, and trapezoid-type inequalities for multiplicatively s-convex functions
Authors: Özcan Serap
Published: February 2025

In this study, we establish new generalizations and results for Simpson, midpoint, and trapezoid-type integral inequalities within the framework of multiplicative calculus. We begin by proving a new identity for multiplicatively differentiable functions. Using this identity, we then obtain a new Simpson-type inequality for multiplicatively

s

s

-convex functions. Additionally, we derive novel integral inequalities related to the right and left sides of the Hermite-Hadamard inequality for multiplicatively

s

s

-convex functions. We also demonstrate that some of the results obtained here improve upon known results, while others are generalizations. Finally, we present some applications to special means.
L
2-exponential ergodicity of stochastic Hamiltonian systems with α-stable Lévy noises
Authors: Bao Jianhai , Wang Jian
Published: February 2025

Based on the hypocoercivity approach due to Villani (2009), Dolbeault, Mouhot and Schmeiser (2015) established a new and simple framework to investigate directly the

L
2

{L^{2}}

-exponential convergence to the equilibrium for the solution to the kinetic Fokker–Planck equation. Nowadays, the general framework advanced by Dolbeault, Mouhot and Schmeiser (2015) is named as the DMS framework for hypocoercivity.
Subsequently, Grothaus and Stilgenbauer (2014) built a dual version of
the DMS framework in the kinetic Fokker–Planck setting. No matter what the abstract DMS framework by Dolbeault, Mouhot and Schmeiser (2015) or the dual counterpart by Grothaus and Stilgenbauer (2014), the densely defined linear operator involved is assumed to be decomposed into two parts, where one part is symmetric and the other part is anti-symmetric.
Thus, the existing DMS framework is not applicable to investigate the

L
2

{L^{2}}

-exponential ergodicity for stochastic Hamiltonian systems with α-stable Lévy noises, where one part of the
associated infinitesimal generators is anti-symmetric whereas the other one is not symmetric at all. In this paper, we shall develop a dual version of the
DMS framework in the fractional kinetic Fokker–Planck setup, where one part of the densely defined linear operator under consideration need not to be symmetric. As a direct application,
we explore the

L
2

{L^{2}}

-exponential ergodicity of stochastic Hamiltonian systems
with α-stable Lévy noises. The proof is also based on Poincaré inequalities for non-local stable-like Dirichlet forms and the potential theory for fractional Riesz potentials.
Association between admission criteria to nurse practitioner program in Israel and academic success: a retrospective study analysis
Authors: Romem Anat , Zalcman Beth G. , Pinchas-Mizrachi Ronit
Published: February 2025

Objectives

Various criteria have been examined in different studies of factors predicting success in nursing studies, and results are not always conclusive. The aim of the current study is to examine the admission criteria factors that are associated with success in master’s degree studies for NPs.

Methods

This retrospective cross-sectional study included 89 student records of nurse practitioner students specializing in either palliative care or geriatrics. The admission criteria, based on the guidelines from the Israeli Ministry of Health, were analyzed in relation to student success in the licensing exam, completion of specialty courses and clinical rotations.

Results

Significant correlations were found between academic variables, such as work experience, post-basic specialty course, years of work experience, and educational background, and degree of success at various points of the program.

Conclusions

Understanding academic and professional development factors can help educators and policymakers develop more effective strategies to enhance the performance and success of NP students in their respective fields.
Exploring the hierarchical antecedents of willingness to communicate and its relationship with utterance fluency in learning Chinese as a foreign language
Authors: Sun Peijian Paul
Published: February 2025

Informed by the willingness to communicate (WTC) model, this study investigated the hierarchical antecedents of WTC and its relationship with utterance fluency in the context of learning Chinese as a foreign language (L2 Chinese). Data were collected from 236 L2 Chinese learners who completed a questionnaire and an L2 Chinese speech competence test. Of these participants, 94 also completed an L2 Chinese speech performance test. The results revealed that L2 Chinese WTC could be hierarchically subject to linguistic (i.e., speech competence), psychological (i.e., speaking anxiety, speaking motivation, and speaking self-efficacy), and sociocultural (i.e., attitudes toward the target language’s society, culture, and classroom instruction) factors as its high-evidence antecedents. The study also found that L2 Chinese WTC did not significantly contribute to any of the four fine-grained measures of utterance fluency (i.e., speech rate, pruned speech rate, articulation rate, and pruned articulation rate). The study concludes with pedagogical insights for teachers.
Factors Influencing the Adoption of Green Libraries for Environmental Sustainability: A Systematic Literature Review
Authors: Tariq Muhammad , Shahzad Khurram , Sulehri Imran Ghaffar
Published: February 2025

This study was conducted to determine the factors influencing the adoption of green libraries for environmental sustainability, to find out the impacts and challenges faced by the librarians to adopt green libraries. For the systematic literature review, the study adopted the “Preferred Reporting Items for the Systematic Review and Meta-analysis” (PRISMA) as the methodology. Different search tools and techniques to access the relevant but extensive literature for the study were applied. Taylor and Francis, Emerald, Sage, IEEE, Elsevier, Wiley, EBSCO, Scopus, and Google Scholar were used to search the required literature. Initially, 844 documents were retrieved and after applying inclusion/exclusion criteria, finally, 33 papers were finalized to conduct the systemic literature review. The findings revealed that external, internal, and institutional goals, technological advancements, Green Library (GL) initiatives, and sustainable development goals (SDGs) are the major factors in adopting GL. Funding issues and the lack of technology are the major challenges faced by librarians. This study is beneficial for the administration, policymakers, LIS schools, and library professionals to gain awareness, planning, and execution to establish green libraries.
Clinical analysis of ten cases of HIV infection combined with acute leukemia
Authors: Fan Shanshan , Qian Chuan , Tao Pengfei , Zhou Qiwen , Lin Sen , Li Konglong , Wang Xi , Min Haiyan
Published: February 2025

Objective

To summarize the clinical characteristics, diagnosis, and treatment experience of human immunodeficiency virus (HIV) infection combined with acute leukemia.

Methods

Ten patients with HIV infection (eight males, two females; mean age of 40 years) were diagnosed with acute leukemia. Clinical features, diagnosis, treatment, and outcomes of these patients were retrospectively analyzed.

Results

Among these ten patients, eight acute myeloid leukemia cases and two acute lymphoblastic leukemia cases were L3; three cases of M3 were positive for the promyelocytic leukemia and Vitamin A acid receptor alpha (PML/RARA) fusion genes, and four cases presented multiple chromosomal structural and numerical abnormalities. CD4+ T cell counts of the ten patients ranged from 84 to 389 cells/μL with a mean of 253.5 cells/μL. Among six patients who received chemotherapy, three cases were alive, two died of sepsis secondary to myelosuppression after chemotherapy, and one was lost to follow-up. Among four patients who did not receive chemotherapy, three died, one had M3 treatment and died with cerebral hemorrhage, and one was lost to follow-up. The maximum survival time was 74 months.

Conclusion

HIV combined with acute leukemia has a complex presentation and rapid progression, early diagnosis and timely initiation of standard chemotherapy along with active antiviral therapy can improve patient’s survival.
Effect of pore structure, mechanical performance, and operational temperature on damping behavior of thermal expandible rubber-based adhesives
Authors: Bolova Işıl , Ateş Halil , Okar Halil İbrahim , Kara Ali
Published: February 2025

Adhesives exhibit multifaceted functionalities beyond adhesion as improving acoustic performance by reducing motion of parts, filling gaps, and facilitating homogeneous stress distribution. The expandable nature of certain adhesives allows them to absorb and dissipate energy effectively, which is beneficial in applications requiring impact resistance. The objectives of this study are acoustic performance measurement by utilizing Oberst and Frequency Response Function (FRF) methods to evaluate the damping capabilities of various rubber-based thermally expandable adhesive formulations; mechanical strength assessment by measuring the lap shear strength to determine the adhesives’ performance under different operational temperatures; pore structure analysis using Scanning Electron Microscopy (SEM) to analyze pore morphology and to investigate its effects on acoustic performance. Differential Scanning Calorimetry (DSC) analysis was conducted to evaluate the thermal properties of rubber adhesive formulations. Glass transition temperatures were determined for the adhesives to understand behavior of damping during the Oberst and FRF tests. Pore structures, amounts, and distribution affected damping behavior of materials directly, but these properties did not cause a reduction on lap shear separtion strength. Operating temperatures and aging conditions affect damping behavior, Young modulus, and adhesion. Salt spray aging did not have significant effect on lap shear strength of rubber adhesive formulations.
Enhanced hippopotamus optimization algorithm and artificial neural network for mechanical component design
Authors: Mehta Pranav , Sait Sadiq M. , Yildiz Betül Sultan , Yildiz Ali Riza
Published: February 2025

Metaheuristics have evolved as a strong family of optimization algorithms capable of handling complicated real-world problems that are frequently non-linear, non-convex, and multidimensional in character. These algorithms efficiently explore and take advantage of search areas by imitating natural processes. In addition to introducing a unique modified hippopotamus optimization algorithm (MHOA) in conjunction with artificial neural networks (ANN), this research examines the most recent developments in metaheuristics. By utilizing ANN’s adaptive learning processes, MHOA improves on the original hippopotamus optimization algorithm (HOA) in terms of convergence and solution quality. The study uses MHOA to solve a number of engineering design optimization issues, such as gearbox weight reduction, robot gripper design, structural optimization, and piston lever design. When compared to more conventional algorithms, MHOA performs better in terms of accuracy, robustness, and convergence time.
Role of emerging theranostic technologies in precision oncology: revolutionizing cancer diagnosis and treatment
Authors: Ayalew Biruk Demisse , Abdullah  , Khan Saim Mahmood , Alemayehu Zemichael Getu , Teferi Mikiyas Gifawosen , Aboye Bethlehem Tamrat , Woldeyohannes Eyob Mekonnen , Sime Brook Lelisa , Tewodros Yeamlak Tariku , Hundisa Muhidin Ibrahim
Published: February 2025

Theranostics is a technique used in precision oncology to combine focused treatments with diagnostic imaging, thereby enabling tailored cancer treatment. Using modern imaging techniques such as positron emission tomography (PET) and single-photon emission computed tomography (SPECT), Theranostics guarantees accurate tumor diagnosis and tailored treatment planning. Radiopharmaceuticals, such as Lutetium-177 (Lu-177) and prostate-specific membrane antigen (PSMA)-targeted therapies, have demonstrated significant clinical enhancements in progression-free and overall survival rates relative to traditional treatments, especially in prostate cancer and neuroendocrine tumors. Emerging technologies such as nanotheranostics and artificial intelligence (AI)-driven tools are enhancing the precision and efficacy of these treatments. However, the widespread application of theranostics is impeded by tumor heterogeneity, elevated prices, and restricted accessibility. Increased research and funding are necessary to address these issues and fully actualize theranostics’ potential to revolutionize cancer detection and therapy. To highlight the above challenges, this review examines diagnostic imaging and therapy advancements, focusing on clinical applications and technologies such as nanotechnology and AI-driven methods.
Translation, Adaptation and Validation of the Music Use and Background Questionnaire (MUSEBAQ) from English to Spanish
Authors: Martínez-Hernández Ana , León-Carrascosa Víctor
Published: February 2025

Studies have revealed that engaging with music can have a multitude of positive effects on one’s health and social well-being. Consequently, extensive research has been conducted on this subject, frequently employing self-reported surveys. However, a notable gap exists in the availability of Spanish-adapted questionnaires catering to the Spanish-speaking population. Addressing this need, the present study introduces the translation, adaptation, and validation to Spanish of the Music Use and Background Questionnaire (MUSEBAQ), a multi-modular self-report instrument that measures music engagement. The sample consisted of 1,493 students of Social Sciences in the Autonomous Community of Madrid. Exploratory factor analysis and reliability tests were conducted on the four modules and after, confirmatory factor analysis was performed on the modules of Music Capacities and Use of Music to confirm the structural validity (modules of Musicianship and Music Preferences are used for the characterization of the sample). The final adapted version showed a robust configuration of the internal structure, revealing high reliability overall and by dimensions. Therefore, the adaptation of the MUSEBAQ questionnaire combines the necessary technical characteristics to be considered a valid a reliable tool to measure music engagement, creating opportunities of further research in the Spanish-speaking population.
The End and Afterlife of Roman Villas in Sicily During the Late Antique, Byzantine, and Islamic Periods
Authors: Castrorao Barba Angelo , Sfameni Carla
Published: February 2025

Roman villas in Sicily are a palimpsest that provide a valuable lens through which to examine the evolving dynamics of settlements, spanning from the decline of opulent residences belonging to late Roman elites to the development of Islamic-era communities and beyond. In light of advancements in postclassical archaeological research in Sicily over recent decades, this article seeks to raise pertinent questions regarding the transformations that these villas experienced between the fifth and twelfth centuries. Over this extensive period, the villas underwent significant metamorphoses and endured substantial destruction due to various earthquakes that struck the island during Late Antiquity. In the Byzantine period, post-villa complexes remained central in the management of rural areas, but within a different socioeconomic context. Furthermore, with the advent of the Islamic conquest, new settlement realities emerged, sometimes in connection with the presence of an Islamized population.
Semi-Pagans? Some Mutations of Non-Christian Thought in Late Antiquity
Authors: Gassman Mattias
Published: February 2025

Ambiguities of religious practice and belief are a crucial feature of the religious transformation of the late Roman world. Recent scholarship on the limits of Christianization has focused, above all, on the tension between the lifestyles of ordinary Christians and bishops’ normative standards. This article turns attention to a different set. As Charles Guignebert suggested in a seminal article (1923), some traditionalists may have embraced Christian ideas without joining Christian churches. This article teases out Christian elements in the thinking of two traditionalist Latin intellectuals. Often identified as a lax Christian, Augustine’s correspondent Nectarius was in fact a Ciceronian pluralist who rejected traditional cults, yet he had not followed his father in embracing Christian practice. A loose parallel can be found in the Platonist commentator Calcidius (most likely active in the early fourth century). Definitely not an adherent of Christianity, Calcidius nonetheless endorsed key Christian ideas, including the Incarnation, the notion of a singular “true god,” and association between primordial floods and the invention of idolatrous cult. To add new terms (such as Guignebert’s semi-pagans) to an already problematic division among pagans, Jews, and various sorts of Christian would only complicate an imperfect model. However, as these examples illustrate, it is necessary to reckon, when analyzing the complex reality of late antique religion, not just with pervasive deviation from Christian norms but also with potential influence of Christian thought on people, otherwise traditionalist in their thinking, who did not belong to Christian churches.
Reconstrucción de una seudoartrosis congénita de radio mediante un trasplante de periostio vascularizado de tibia: reporte de un caso
Authors: Saralegui Pilar , Soldado Francisco
Published: February 2025

La seudoartrosis congénita de radio es un cuadro raro, comúnmente asociado a neurofibromatosis o displasia fibrosa. Presentamos el primer caso de un colgajo de periostio vascularizado utilizado para tratar la seudoartrosis congénita de radio. Se trata de un varón de 14 meses de edad con neurofibromatosis tipo 1, acortamiento severo del antebrazo y desviación radial de la muñeca. La prono-supinación estaba limitada (60°-80°). En las radiografías, se observó una seudoartrosis del tercio distal del radio derecho. El tratamiento quirúrgico consistió en desbridamiento, fijación ósea con una aguja de Kirschner y la colocación de un colgajo de periostio vascularizado de tibia de la pierna contralateral cubriendo el sitio seudoartrósico. A las 3 semanas de la operación, se observó la formación de callo en la radiografía, con flexo-extensión completa de la muñeca y prono-supinación de 90°-90°. A las 5 semanas, reanudó sus actividades sin protección ortésica. El uso de periostio vascularizado de tibia es una opción innovadora para tratar la seudoartrosis congénita de radio, ya que la consolidación ósea y el retorno a las actividades son rápidos, sin morbilidad asociada en el sitio donante.
Articulación metacarpofalángica bloqueada. Serie de casos, investigación anatómica y revisión bibliográfica
Authors: Teruya Gustavo José , Chaves Andrea Silvana , Viollaz Gonzalo Martín , Muratore Álvaro Javier , Tedeschi Alejandro , Durán Rafael , Gómez Diego José
Published: February 2025

Introducción: El bloqueo articular a nivel metacarpofalángico es un cuadro infrecuente que se caracteriza por la pérdida repentina de la extensión máxima.
Objetivos: Presentar los resultados de nuestra serie de casos, describir la investigación anatómicarealizada y proponer un protocolo de tratamiento para este cuadro.
Materiales y Métodos: Se presenta a 9 pacientes tratados entre 2006 y 2023, que concurrieron a la consulta por pérdida de la extensión de la articulación metacarpofalángica mientras realizaban alguna tarea manual de fuerza.
Resultados: Ocho fueron operados y, en uno, se logró el desbloqueo con su respectiva maniobra de reducción. Todos recuperaron el rango de movilidad completo sin complicaciones ni recidivas.
Conclusiones: El bloqueo metacarpofalángico es infrecuente. Como protocolo, aconsejamos intentar una reducción cerrada y, si es necesaria la cirugía, utilizar un abordaje palmar para el dedo mayor o palmar-radial, ya que expone el ligamento colateral accesorio por destrabar y resecar el pico óseo a fin de evitar la recidiva del enganche.
Exposición a la radiación en Ortopedia y Traumatología, en la Argentina
Authors: Cubecino Adriana , Garabano Germán , Gamarra Débora , Simesen de Bielke Harold , Sierto Mónica N. , Robador Nicolás A.
Published: February 2025

Introducción: Múltiples procedimientos en cirugía ortopédica implican el uso de imágenes radioscópicas, lo que plantea un riesgo mayor de exposición a radiación ionizante para los cirujanos. Este estudio tiene como objetivo identificar las prácticas, la frecuencia de uso de imágenes intraoperatorias, el nivel de conocimiento y el empleo de elementos de protección radiológica de los médicos especialistas en ortopedia y traumatología de la Argentina.
Materiales y Métodos: Estudio analítico observacional transversal. Se realizó en base a una encuesta en línea a traumatólogos de nuestro país, entre septiembre de 2020 y octubre de 2021. Mediante 18 preguntas se recabaron datos sociodemográficos, profesionales y laborales relacionados con el uso de la radioscopia intraoperatoria, las medidas de protección y el respectivo conocimiento.
Resultados: Se recibieron 919 respuestas a la encuesta. La mitad de los participantes (48,7%) utiliza radioscopia más de una vez por semana. El 73,9% desconoce el tiempo real de exposición, la mayoría (60,5%) ignora si se renuevan los elementos de protección, y solo el 10% usa dosímetro. El elemento de protección más utilizado es el chaleco de plomo; sin embargo, solo un tercio emplea protección tiroidea. La formaciónacadémica en radiaciones ionizantes es insuficiente y al 97% de los encuestados le interesaría recibirla.
Conclusiones: Existe una necesidad de concientización sobre la radiación por parte del cirujano ortopédico. La protección radiológica en la mayoría de los procedimientos quirúrgicos es inadecuada, no existen programas formativos obligatorios, protocolos de uso ni el respectivocontrol.
Dr. Jorge Abel Groiso
Authors: Miscione Horacio Fernando
Published: February 2025

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Wspieranie młodzieży zagrożonej samobójstwem
Authors: Kępa-Miazga Magdalena
Published: February 2025

W artykule opisano funkcjonowanie młodzieży z myślami, które odbierają nadzieję i niosą ból emocjonalny. Przedstawiono w nim sposoby wspierania młodzieży dotkniętej myślami oraz zachowaniami samobójczymi i podkreślono rangę tego społecznego problemu. Przeciwdziałanie podejmowaniu prób samobójczych przez młodzież powinno obejmować interdyscyplinarne i holistyczne oddziaływanie na człowieka. Podstawą tych oddziaływań jest odnalezienie przyczyny zaistniałego stanu rzeczy i dostosowanie metod pracy z młodym człowiekiem. Kryzys psychiczny może dotknąć osoby w każdym wieku, niezależnie od statusu społecznego. Ważne w tym aspekcie jest zwrócenie się po profesjonalną pomoc specjalistyczną, gdyż otwarcie się na wsparcie jest pierwszym krokiem mającym na celu zmianę obecnej sytuacji. Warto podkreślić znaczenie oddziaływania metod psychoterapii poznawczo-behawioralnej we wspieraniu osób zagrożonych samobójstwem.
Paving the way for new antimicrobial peptides through molecular de-extinction
Authors: Osiro Karen O. , Gil-Ley Abel , Fernandes Fabiano C. , de Oliveira Kamila B. S. , de la Fuente-Nunez Cesar , Franco Octavio L.
Published: February 2025

Molecular de-extinction has emerged as a novel strategy for studying biological molecules throughout evolutionary history. Among the myriad possibilities offered by ancient genomes and proteomes, antimicrobial peptides (AMPs) stand out as particularly promising alternatives to traditional antibiotics. Various strategies, including software tools and advanced deep learning models, have been used to mine these host defense peptides. For example, computational analysis of disulfide bond patterns has led to the identification of six previously uncharacterized β-defensins in extinct and critically endangered species. Additionally, artificial intelligence and machine learning have been utilized to uncover ancient antibiotics, revealing numerous candidates, including mammuthusin, and elephasin, which display inhibitory effects toward pathogens in vitro and in vivo. These innovations promise to discover novel antibiotics and deepen our insight into evolutionary processes.
Cardiac pacing on the verge of great changes: updating the issue
Authors: Lebedev D. S. , Lebedeva V. K.
Published: February 2025

Обзор накопленных к настоящему времени данных касательно физилогичности электрокардиостимуляции, обоснование новых методик, классификации о обсуждение нерешенных проблем в области стимуляции сердца
Flowering prediction for flood-irrigated rice in the Midwest and North regions of Brazil
Authors: Justino Ludmilla Ferreira , Honorio Filho Gutemberg Resende , Matta David Henriques da , Stone Luís Fernando , Heinemann Alexandre Bryan
Published: February 2025

ABSTRACT This study aimed to analyze the influence of climatic and geographic variables on the flowering process of flood-irrigated rice in the Midwest and North regions of Brazil. Agronomic data from the breeding program were related to the following variables: air temperature, relative humidity, global solar radiation, rainfall, degree days, latitude, longitude, and altitude. The analysis was performed using Multiple Linear Regression (MLR) and Generalized Additive (GAM) models. Cross-validation determined the most suitable model. The GAM model showed the best performance for both regions. In the Midwest and North of Brazil, flowering was strongly influenced by climate variables related to temperature. The rise in minimum temperatures tends to advance flowering. Higher minimum accumulated temperatures tend to delay flowering.