bluuebunny/crossref_metadata_2025 huggingface dataset:
Glycosides as Potential Medicinal Components for Ulcerative Colitis: A Review
Authors: Niu Yating , Zhang Jun , Shi Dianhua , Zang Weibiao , Niu Jianguo
Published: July 2023

Ulcerative colitis (UC) is a chronic, non-specific disease of unknown etiology. The disease develops mainly in the rectum or colon, and the main clinical symptoms include abdominal pain, diarrhea, and purulent bloody stools, with a wide variation in severity. The specific causative factors and pathogenesis of the disease are not yet clear, but most scholars believe that the disease is caused by the interaction of genetic, environmental, infectious, immune, and intestinal flora factors. As for the treatment of UC, medications are commonly used in clinical practice, mainly including aminosalicylates, glucocorticoids, and immunosuppressive drugs. However, due to the many complications associated with conventional drug therapy and the tendency for UC to recur, there is an urgent need to discover new, safer, and more effective drugs. Natural compounds with biodiversity and chemical structure diversity from medicinal plants are the most reliable source for the development of new drug precursors. Evidence suggests that glycosides may reduce the development and progression of UC by modulating anti-inflammatory responses, inhibiting oxidative stress, suppressing abnormal immune responses, and regulating signal transduction. In this manuscript, we provide a review of the epidemiology of UC and the available drugs for disease prevention and treatment. In addition, we demonstrate the protective or therapeutic role of glycosides in UC and describe the possible mechanisms of action to provide a theoretical basis for preclinical studies in drug development.
Uniformly Dispersed Sb-Nanodot Constructed by In Situ Confined Polymerization of Ionic Liquids for High-Performance Potassium-Ion Batteries
Authors: Zhang Cunliang , Chen Zhengyuan , Zhang Haojie , Liu Yanmei , Wei Wei , Zhou Yanli , Xu Maotian
Published: July 2023

Antimony (Sb) is a potential candidate anode for potassium-ion batteries (PIBs) owing to its high theoretical capacity. However; in the process of potassium alloying reaction; the huge volume expansion (about 407%) leads to pulverization of active substance as well as loss of electrical contact resulting in rapidly declining capacity. Herein; uniformly dispersed Sb-Nanodot in carbon frameworks (Sb-ND@C) were constructed by in situ confined polymerization of ionic liquids. Attributed to the uniformly dispersed Sb-ND and confinement effect of carbon frameworks; as anode for PIBs; Sb-ND@C delivered a superior rate capability (320.1 mA h g−1 at 5 A g−1) and an outstanding cycling stability (486 mA h g−1 after 1000 cycles; achieving 89.8% capacity retention). This work offers a facile route to prepare highly dispersed metal-Nanodot via the in situ polymerization of ionic liquid for high-performance metal-ion batteries
Platycodonis Radix Alleviates LPS-Induced Lung Inflammation through Modulation of TRPA1 Channels
Authors: Yang Tan , Zhao Shuang , Yuan Yu , Zhao Xiaotong , Bu Fanjie , Zhang Zhiyuan , Li Qianqian , Li Yaxin , Wei Zilu , Sun Xiuyan , Zhang Yanqing , Xie Junbo
Published: July 2023

Platycodonis Radix (PR), a widely consumed herbal food, and its bioactive constituents, platycodins, have therapeutic potential for lung inflammation. Transient Receptor Potential Ankyrin 1 (TRPA1), which is essential for the control of inflammation, may be involved in the development of inflammation in the lungs. The aim of this study was to determine the TRPA1-targeted effects of PR against pulmonary inflammation and to investigate the affinity of PR constituents for TRPA1 and their potential mechanisms of action. Using a C57BL/6J mouse lipopolysaccharides (LPS) intratracheal instillation pneumonia model and advanced analytical techniques (UPLC-Q-TOF-MS/MS, molecular docking, immuno-fluorescence), five platycodins were isolated from PR, and the interaction between these platycodins and hTRPA1 was verified. Additionally, we analyzed the impact of platycodins on LPS-induced TRPA1 expression and calcium influx in BEAS-2B cells. The results indicated that PR treatment significantly reduced the severity of LPS-triggered inflammation in the mouse model. Interestingly, there was a mild increase in the expression of TRPA1 caused by PR in healthy mice. Among five isolated platycodins identified in the PR extract, Platycodin D3 (PD3) showed the highest affinity for hTRPA1. The interaction between platycodins and TRPA1 was verified through molecular docking methods, highlighting the significance of the S5–S6 pore-forming loop in TRPA1 and the unique structural attributes of platycodins. Furthermore, PD3 significantly reduced LPS-induced TRPA1 expression and calcium ion influx in BEAS-2B cells, substantiating its own role as an effective TRPA1 modulator. In conclusion, PR and platycodins, especially PD3, show promise as potential lung inflammation therapeutics. Further research should explore the precise mechanisms by which platycodins modulate TRPA1 and their broader therapeutic potential.
Amorphous/Nanocrystalline High-Entropy CoCrFeNiTix Thin Films with Low Thermal Coefficient of Resistivity Obtained via Magnetron Deposition
Authors: Poliakov Maksim , Kovalev Dmitry , Vadchenko Sergei , Moskovskikh Dmitry , Kiryukhantsev-Korneev Philipp , Volkova Lidiya , Dudin Alexander , Orlov Andrey , Goryachev Andrey , Rogachev Alexander
Published: July 2023

High-entropy alloys are promising materials for novel thin-film resistors since they have high resistivity and a low-temperature coefficient of resistivity (TCR). In this work, a new high-entropy thin-film CoCrFeNiTix was deposited on a Si/SiO2 substrate by means of magnetron sputtering of the multi-component target produced by hot pressing of the powder mixture. The samples possessed a thickness of 130–230 nm and an amorphous atomic structure with nanocrystallite traces. This structure persisted after being annealed up to 400 °C, which was confirmed using X-ray and electron diffraction. The film had a single-phase structure with a smooth surface and a uniform distribution of all elements. The obtained film served for microresistor elaboration, which was produced using the lithography technique and tested in a temperature range from −60 °C up to 200 °C. Resistivity at room temperature was estimated as 2.37 μOhm·m. The results have demonstrated that TCR depends on temperature according to the simple linear law in a range from −60 °C up to 130 °C, changing its value from −78 ppm/°C at low temperatures to −6.6 ppm/°C at 130 °C. Such characteristics show the possibility of using these high-entropy alloy films for resistive elements in contemporary and future micro-electronic devices.
Kiwifruit’s Allergy in Children: What Do We Know?
Authors: Bringheli Ivana , Brindisi Giulia , Morelli Rebecca , Marchetti Lavinia , Cela Ludovica , Gravina Alessandro , Pastore Francesca , Semeraro Antonio , Cinicola Bianca , Capponi Martina , Gori Alessandra , Pignataro Elia , Piccioni Maria Grazia , Zicari Anna Maria , Anania Caterina
Published: July 2023

Kiwifruit allergy is an emerging pathological condition in both general and pediatric populations with a wide range of symptoms linked to variable molecular patterns, justifying systemic and cross-reactions with other allergens (i.e., latex, pollen, and fruit). Skin prick test (SPT), specific serum IgE (Act d 1, Act d 2, Act d 5, Act d 8, and Act d 10) directed against five out of thirteen molecular allergens described in the literature, and oral test challenge with kiwifruit are available for defining diagnosis. The management is similar to that of other food allergies, mostly based on an elimination diet. Although kiwi allergy has been on the rise in recent years, few studies have evaluated the clinical characteristics and methods of investigating this form of allergy. Data collected so far show severe allergic reaction to be more frequent in children compared to adults. Therefore, the aim of this review is to collect the reported clinical features and the available association with specific molecular patterns of recognition to better understand how to manage these patients and improve daily clinical practice.
Special Issue: Recent Research on Hospital-Acquired Bloodstream Infections
Authors: Ioannou Petros , Kofteridis Diamantis P.
Published: July 2023

Hospital-acquired infections (HAIs) are infections that occur in patients 48 h after admission to hospital [...]
Kinin B2 Receptor Mediates Cisplatin-Induced Painful Peripheral Neuropathy by Intracellular Kinase Pathways and TRPA1 Channel Sensitisation
Authors: Becker Gabriela , Fialho Maria Fernanda Pessano , Brum Evelyne Silva , Oliveira Sara Marchesan
Published: July 2023

Chemotherapy-induced peripheral neuropathy is a severe clinical problem frequently associated with cisplatin use. Although its pathophysiology is poorly understood, it is known that kinin receptors and the transient receptor potential ankyrin 1 (TRPA1) channel play a significant role in the peripheral neuropathy induced by cisplatin in rodents. However, the role of signalling pathways downstream from B2 kinin receptors activation and sensitisation of the TRPA1 channel remains unknown in this model. The cisplatin-induced neuropathy model caused mechanical and cold allodynia in male Swiss mice. Antagonists for kinin B2 and B1 receptors and the TRPA1 channel attenuated the painful parameters. Local sub-nociceptive doses of kinin B2 receptor (bradykinin) and TRPA1 channel (allyl isothiocyanate; AITC) agonists enhanced the painful parameters in cisplatin-treated mice, which their respective antagonists attenuated. Furthermore, we demonstrated the interaction between the kinin B2 receptor and the TRPA1 channel in cisplatin-induced peripheral neuropathy since phospholipase C (PLC) and protein kinase C epsilon (PKCε) inhibitors attenuated the increase in mechanical and cold allodynia evoked by bradykinin and AITC in cisplatin-treated mice. Therefore, regulating the activation of signalling pathways downstream from the kinin B2 receptors activation and TRPA1 channel sensitisation can mitigate the painful peripheral neuropathy decurrent of the oncology treatment with cisplatin.
Responsive Sensory Evaluation to Develop Flexible Taste-Masked Paediatric Primaquine Tablets against Malaria for Low-Resource Settings
Authors: Ranmal Sejal R. , Lavarde Marc , Wallon Elodie , Issa Samar , Taylor Walter R. , Nguyen Ngoc Pouplin Julie L. A. , Tuleu Catherine , Pensé-Lhéritier Anne-Marie
Published: July 2023

Primaquine is an important antimalarial drug for malaria transmission blocking and radical cure, but it is not currently available in child-friendly formulations in appropriate doses. Adult-strength tablets are often crushed and dissolved in water to obtain the required dose, which exposes the drug’s bitter taste. As part of the developing paediatric primaquine (DPP) project, this study adopted a responsive sensory pharmaceutics approach by integrating real-time formulation development and pre-clinical taste assessment to develop palatable, flavour-infused primaquine tablets. A design of experiment (DoE) approach was used to screen different taste-masking agents and excipient blends with trained, expert sensory assessors, with quinine hydrochloride as a model bitter tastant. The taste-masking efficacy of selected prototype formulation blends was validated with naïve assessors using the highest 15 mg primaquine dose. The mean bitterness intensity rating, measured on a discrete 11-point scale, was halved from 7.04 for the unflavoured control to 2.74–3.70 for the formulation blends. Sucralose had the biggest impact on bitterness suppression and improving palatability. Two different flavouring systems have been developed, and their acceptability in paediatric patients will be assessed as part of upcoming validation field clinical trials in Africa.
Aluminum Adjuvants—‘Back to the Future’
Authors: Laera Donatello , HogenEsch Harm , O’Hagan Derek T.
Published: July 2023

Aluminum-based adjuvants will continue to be a key component of currently approved and next generation vaccines, including important combination vaccines. The widespread use of aluminum adjuvants is due to their excellent safety profile, which has been established through the use of hundreds of millions of doses in humans over many years. In addition, they are inexpensive, readily available, and are well known and generally accepted by regulatory agencies. Moreover, they offer a very flexible platform, to which many vaccine components can be adsorbed, enabling the preparation of liquid formulations, which typically have a long shelf life under refrigerated conditions. Nevertheless, despite their extensive use, they are perceived as relatively ‘weak’ vaccine adjuvants. Hence, there have been many attempts to improve their performance, which typically involves co-delivery of immune potentiators, including Toll-like receptor (TLR) agonists. This approach has allowed for the development of improved aluminum adjuvants for inclusion in licensed vaccines against HPV, HBV, and COVID-19, with others likely to follow. This review summarizes the various aluminum salts that are used in vaccines and highlights how they are prepared. We focus on the analytical challenges that remain to allowing the creation of well-characterized formulations, particularly those involving multiple antigens. In addition, we highlight how aluminum is being used to create the next generation of improved adjuvants through the adsorption and delivery of various TLR agonists.
Broadband and Low-Loss Silicon Photonic Directional Coupler for Signal Power Tapping on the 3 μm SOI Waveguide Platform
Authors: Lv Dongsheng , Wu Longsheng , Liu Chenyang , Li Ang , Wang Ruxue , Wu Aimin
Published: July 2023

Silicon photonics (SiPh) has emerged as a promising technology for photonic integrated circuits (PICs). One of the basic components in SiPh is the directional coupler (DC), which plays an important role in signal monitoring with the requirement of low wavelength dependence and low loss. This paper proposes a broadband and low-loss DC designed for signal power tapping on the 3 μm silicon-on-insulator (SOI) waveguide platform. By utilizing the advantages of multi-micron waveguides and replacing one of the straight waveguides with an optimized arc-shaped waveguide in the coupling region, the proposed DC enhances spectral stability and improves transmission with negligible loss. Experimental evidence indicates that the proposed DC showcases a minimal variation in the tapping ratio. From 1470 nm to 1630 nm, the largest deviation away from the tapping ratio at 1550 nm is 1.433%. Additionally, the device exhibits a low excess loss of −0.27 dB. These results suggest that the proposed device is well-suited to reliable signal power tapping and monitoring, particularly within PICs.
Culturomics and Circular Agronomy: Two Sides of the Same Coin for the Design of a Tailored Biofertilizer for the Semi-Halophyte Mesembryanthemum crystallinum
Authors: Pajuelo Eloísa , Flores-Duarte Noris J. , Navarro-Torre Salvadora , Rodríguez-Llorente Ignacio D. , Mateos-Naranjo Enrique , Redondo-Gómez Susana , Carrasco López José A.
Published: July 2023

According to the EU, the global consumption of biomass, fossil fuels, metals, and minerals is expected to double by 2050, while waste will increase by 70%. In this context, the Circular Economy Action Plan (CEAP) intends to integrate development and sustainability. In this regard, tailored biofertilizers based on plant growth-promoting bacteria (PGPB) can improve plant yield with fewer inputs. In our project, an autochthonous halophyte of the Andalusian marshes, namely Mesembryanthemum crystallinum, was selected for its interest as a source of pharmaceuticals and nutraceuticals. The aim of this work was to use a culturomics approach for the isolation of specific PGPB and endophytes able to promote plant growth and, eventually, modulate the metabolome of the plant. For this purpose, a specific culture medium based on M. crystallinum biomass, called Mesem Agar (MA), was elaborated. Bacteria of three compartments (rhizosphere soil, root endophytes, and shoot endophytes) were isolated on standard tryptone soy agar (TSA) and MA in order to obtain two independent collections. A higher number of bacteria were isolated on TSA than in MA (47 vs. 37). All the bacteria were identified, and although some of them were isolated in both media (Pseudomonas, Bacillus, Priestia, Rosellomorea, etc.), either medium allowed the isolation of specific members of the M. crystallinum microbiome such as Leclercia, Curtobacterium, Pantoea, Lysinibacillus, Mesobacillus, Glutamicibacter, etc. Plant growth-promoting properties and extracellular degrading activities of all the strains were determined, and distinct patterns were found in both media. The three best bacteria of each collection were selected in order to produce two different consortia, whose effects on seed germination, root colonization, plant growth and physiology, and metabolomics were analyzed. Additionally, the results of the plant metabolome revealed a differential accumulation of several primary and secondary metabolites with pharmaceutical properties. Overall, the results demonstrated the feasibility of using “low cost media” based on plant biomass to carry out a culturomics approach in order to isolate the most suitable bacteria for biofertilizers. In this way, a circular model is established in which bacteria help plants to grow, and, in turn, a medium based on plant wastes supports bacterial growth at low prices, which is the reason why this approach can be considered within the model of “circular agronomy”.
Whole-Genome Identification of Regulatory Function of CDPK Gene Families in Cold Stress Response for Prunus mume and Prunus mume var. Tortuosa
Authors: Miao Runtian , Li Mingyu , Wen Zhenying , Meng Juan , Liu Xu , Fan Dongqing , Lv Wenjuan , Cheng Tangren , Zhang Qixiang , Sun Lidan
Published: July 2023

Calcium-dependent protein kinases (CDPK) are known to mediate plant growth and development and respond to various environmental changes. Here, we performed whole-genome identification of CDPK families in cultivated and wild mei (Prunus mume). We identified 14 and 17 CDPK genes in P. mume and P. mume var. Tortuosa genomes, respectively. All 270 CPDK proteins were classified into four clade, displaying frequent homologies between these two genomes and those of other Rosaceae species. Exon/intron structure, motif and synteny blocks were conserved between P. mume and P. mume var. Tortuosa. The interaction network revealed all PmCDPK and PmvCDPK proteins is interacted with respiratory burst oxidase homologs (RBOHs) and mitogen-activated protein kinase (MAPK). RNA-seq data analysis of cold experiments show that cis-acting elements in the PmCDPK genes, especially PmCDPK14, are associated with cold hardiness. Our results provide and broad insights into CDPK gene families in mei and their role in modulating cold stress response in plants.
Efficient Removal of Carcinogenic Azo Dyes from Water Using Iron(II) Clathrochelate Derived Metalorganic Copolymers Made from a Copper-Catalyzed [4 + 2] Cyclobenzannulation Reaction
Authors: Baig Noorullah , Shetty Suchetha , Bargakshatriya Rupa , Pramanik Sumit Kumar , Alameddine Bassam
Published: July 2023

A novel synthetic strategy is disclosed to prepare a new class of metalorganic copolymers that contain iron(II) clathrochelate building blocks by employing a mild and cost-effective copper-catalyzed [4 + 2] cyclobenzannulation reaction, using three specially designed diethynyl iron(II) clathrochelate synthons. The target copolymers CBP1-3 were isolated in high purity and excellent yields as proven by their structural and photophysical characterization, namely, Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS) and UV–VIS absorption and emission spectroscopies. The thermogravimetric analysis (TGA) of CBP1-3 revealed an excellent chemical stability. Investigation of the adsorption properties of the target copolymers towards the carcinogenic methyl red dye from aqueous solution revealed a quantitative uptake in 30 min. Isothermal adsorption studies disclosed that methyl red uptake from aqueous solution followed the Langmuir model for all of the target copolymers, reaching a maximum adsorption capacity (qm) of 431 mg g−. Kinetic investigation revealed that the adsorption followed pseudo-first-order with an equilibrium adsorption capacity (qe,cal) of 79.35 mg g− and whose sorption property was sustained even after its reuse several times.
A Review of Pump Cavitation Fault Detection Methods Based on Different Signals
Authors: Liu Xiaohui , Mou Jiegang , Xu Xin , Qiu Zhi , Dong Buyu
Published: July 2023

As one of the research hotspots in the field of pumps, cavitation detection plays an important role in equipment maintenance and cost-saving. Based on this, this paper analyzes detection methods of cavitation faults based on different signals, including vibration signals, acoustic emission signals, noise signals, and pressure pulsation signals. First, the principle of each detection method is introduced. Then, the research status of the four detection methods is summarized from the aspects of cavitation-induced signal characteristics, signal processing methods, feature extraction, intelligent algorithm identification of cavitation state, detection efficiency, and measurement point distribution position. Among these methods, we focus on the most widely used one, the vibration method. The advantages and disadvantages of various detection methods are analyzed and proposed: acoustic methods including noise and acoustic emission can detect early cavitation very well; the vibration method is usually chosen first due to its universality; the anti-interference ability of the pressure pulsation method is relatively strong. Finally, the development trend of detecting cavitation faults based on signals is given: continue to optimize the existing detection methods; intelligent algorithms such as reinforcement learning and deep reinforcement learning will be gradually integrated into the field of cavitation status identification in the future; detection systems still need to be further improved to accommodate different types of pumps; advanced sensing devices combined with advanced signal processing techniques are one of the effective means to detect cavitation in a timely manner; draw on other fault detection methods such as bearing faults and motor faults.
The Phenomenological and the Symbolical in Richir’s “Quasi-Theology”
Authors: Ekweariri Dominic Nnaemeka
Published: July 2023

If a new generation of phenomenologists (Emmanuel Levinas, Michel Henry, Jean-Luc Marion, Jean-Louis Chrétien, Jean-François Courtine) in France sought to overcome the “methodic atheism” imposed on the phenomenological method by the fathers of phenomenology, it was at the price of going beyond experience immanent to existence which targeted the invisible, and therefore of lacking a discourse on the critical restriction of the phenomenological method and on the points of contact between phenomenology and theology. The task of this paper is to show how this lack is overcome by Marc Richir’s “quasi theology” viewed from his articulation of the relationship between the phenomenological and the symbolical. This paper argues that whereas for the new French phenomenologists it is usually a question of a subreptitious crossing from one discipline to another, in Richir, what we have is an enigmatic relationship of the overlap between phenomenology and the symbolical. While Richir was only interested in the articulation of the relationship between the phenomenological, the symbolical and the absolute transcendence, his thoughts motivate us to explore, following Emmanuel Falque’s approach, the reciprocal transformation between phenomenology and theology. The paper concludes, on the one hand, that experience remains the immanent ground for phenomenology and theological science and, on the other, that Richir’s approach could be understood as a “metaphysical phenomenology”.
Predicting Stock Market Volatility Using MODWT with HyFIS and FS.HGD Models
Authors: Alenezy Abdullah H. , Ismail Mohd Tahir , Wadi Sadam AL , Jaber Jamil J.
Published: July 2023

We enhance the precision of predicting daily stock market price volatility using the maximum overlapping discrete wavelet transform (MODWT) spectral model and two learning approaches: the heuristic gradient descent (FS.HGD) and hybrid neural fuzzy inference system (HyFIS). The FS.HGD approach iteratively updates the model’s parameters based on the error function gradient, while the HyFIS approach combines the advantages of neural networks and fuzzy logic systems to create a more robust and accurate learning model. The MODWT uses five mathematical functions to form a discrete wavelet basis. The dataset used includes the daily closing prices of the Tadawul stock market from August 2011 to December 2019. Inputs were selected based on multiple regression, tolerance, and variance inflation factor tests, and the oil price (Loil) and repo rate (Repo) were identified as input variables. The output variable is represented by the logarithm of the Tadawul stock market price (LSCS). MODWT-LA8 (ARIMA(1,1,0) with drift) outperforms other WT functions on the 80% dataset, with an ME of (0.00000532), MAE of (0.003214182), and MAPE of (0.06449683). The addition of WT functions to the FS.HGD and HyFIS models increases their forecasting ability. Based on the reduced RMSE (0.048), MAE (0.038), and MAPE (0.538), the MODWT-LA8-FS.HGD outperforms traditional models in predicting the remaining 20% of datasets.
A Multipath Error Reduction Method for BDS Using Tikhonov Regularization with Parameter Optimization
Authors: Li Xinzhong , Xiong Yongliang , Xu Shaoguang , Chen Weiwei , Zhao Ban , Zhang Rui
Published: July 2023

Multipath error is an important factor restricting the relative positioning accuracy of the Beidou Navigation Satellite System (BDS). Because of the complexity of the reflection environment, the mathematical modeling of multipath errors is quite difficult. The sidereal filtering algorithm corrects multipath errors by using the feature of period repetition, which can greatly reduce its influence and improve the accuracy of positioning and attitude measurement. In view of the constellation heterogeneity of BDS, it is more complicated to apply sideral filtering. Based on the reconstructed single-difference residual of the carrier phase, the multipath repetition time of the Beidou satellite is estimated using the idea of segmentation. The Tikhonov regularization method and the classical wavelet method are used to extract the multipath of the single-difference residual of the carrier phase, and the “clean” sequence of the single-difference residual is obtained. The experimental results show that it is feasible to extract the multipath error correctly by Tikhonov regularization, and the multipath error is smoother than the original residual measurement. Furthermore, the estimation method of the regularization parameter is further optimized. After using the optimized Tikhonov regularization method with sidereal filtering, the mean RMS improvements of GEO, IGSO, and MEO satellites are 45.9%, 38.2%, and 37.5%, respectively. The positioning accuracy on E, N, and U components is improved by 24.8%, 26.3%, and 42.7%, respectively. The attitude resolution accuracy is improved by 22.9% in the yaw angle and 12.6% in the pitch angle. The proposed method can be an alternative BDS multipath error modeling and mitigation approach.
Medicines and Medication Literacy: Social Practices and Use of Information
Authors: Lopes Noémia , Pegado Elsa , Egreja Catarina , Rodrigues Carla , Fernandes Ana Isabel
Published: July 2023

This article discusses results from a sociological study on (i) the sources and use of information on medicines and/or supplements and (ii) the self-assessment of how informed participants were about the last medicine or supplement they purchased. It seeks to demonstrate the plurality of information sources (expert and lay) that individuals call upon—with which they build up their medication literacy—and their perception of the information they have. While these social components of literacy are scarcely visible in available studies, the need to produce knowledge on them is a requisite for a more laypeople-centred approach in public policies seeking to promote medication literacy. A questionnaire was applied in-person (n = 1107) in urban pharmacies in Lisbon and Porto (Portugal). Results show expert information (medical and pharmaceutical) as the dominant reference, followed by lay sources (family/friends/colleagues), while digital sources were less valued than interpersonal ones. This interpersonal dimension was a relevant factor in the building of trust in information. The self-assessment of the information on medication was higher in functional literacy and lower in comprehensive literacy. Studies on medication literacy are particularly relevant in the current context of the expansion and diversification of medicines’ use and of individuals’ growing autonomy in their consumption habits.
Static Load Test Analysis of T-Beam Bridge Shear Strengthening by Prestressed Steel Wire Rope Embedded in Polyurethane Cement (PSWR-PUC)
Authors: Li Bochen , Liu Hongbo , Jian Jiashuo , Gao Hongshuai
Published: July 2023

Many bridges suffer from aging and deterioration problems and need to be strengthened. PSWR-PUC is an emerging structural strengthening technology that enhances the load-bearing capacity of concrete bridges by embedding prestressed steel wire ropes into polyurethane cement. This paper focuses on investigating the shear reinforcement effectiveness of PSWR-PUC. Firstly, the composition of PSWR-PUC is introduced. Subsequently, two T-beam bridges in similar service condition are selected, and shear strengthening schemes involving PSWR-PUC and externally bonded steel plates are devised. Lastly, static loading tests are conducted, and the deflection and strain data of the two bridges before and after reinforcement intervention are analyzed. The results indicate that both strengthening methods improve the bridge load-carrying capacity. However, compared to the bridge strengthened with the externally bonded steel plate method, the deflections in the bridge strengthened with PSWR-PUC decreased by 36.8% and 42.1%, the strains decreased by 18% and 23%, and the shear stiffness was improved to a greater extent. These results verified that the PSWR-PUC strengthening method is effective for improving structural capacity and performance. This study will contribute to an in-depth understanding of the performance characteristics and application scope of PSWR-PUC shear strengthening technology, and it provides a scientific basis and guidance for practical engineering applications.
Chemical Recycling of Used Motor Oil by Catalytic Cracking with Metal-Doped Aluminum Silicate Catalysts
Authors: Almeida Streitwieser Daniela , Arteaga Arturo , Gallo-Cordova Alvaro , Hidrobo Alexis , Ponce Sebastian
Published: July 2023

The chemical recycling of used motor oil via catalytic cracking to convert it into secondary diesel-like fuels is a sustainable and technically attractive solution for managing environmental concerns associated with traditional disposal. In this context, this study was conducted to screen basic and acidic-aluminum silicate catalysts doped with different metals, including Mg, Zn, Cu, and Ni. The catalysts were thoroughly characterized using various techniques such as N2 adsorption–desorption isotherms, FT-IR spectroscopy, and TG analysis. The liquid and gaseous products were identified using GC, and their characteristics were compared with acceptable ranges from ASTM characterization methods for diesel fuel. The results showed that metal doping improved the performance of the catalysts, resulting in higher conversion rates of up to 65%, compared to thermal (15%) and aluminum silicates (≈20%). Among all catalysts, basic aluminum silicates doped with Ni showed the best catalytic performance, with conversions and yields three times higher than aluminum silicate catalysts. These findings significantly contribute to developing efficient and eco-friendly processes for the chemical recycling of used motor oil. This study highlights the potential of basic aluminum silicates doped with Ni as a promising catalyst for catalytic cracking and encourages further research in this area.
Scaling Up Pro-Poor Agrobiodiversity Interventions as a Development Option
Authors: Bernis-Fonteneau Agnès , Alcadi Rima , Frangella Marco , Jarvis Devra I.
Published: July 2023

Pro-poor interventions that use agrobiodiversity for development actions are widely considered relevant only at small scales. Agrobiodiversity interventions are often left out of national-level/large-scale development planning. Scaling-up modalities include adaptation, diffusion, replication, value addition, and temporal scaling up. We undertook a review of 119 interventions that use agrobiodiversity for both the crop and the livestock sector. The interventions ranged from improving the availability of materials and information through management and market-oriented actions to changing norms and enabling policies. The interventions are also organized in accordance with farming-community goals and constraints. The open-access multilingual Diversity Assessment Tool for Agrobiodiversity and Resilience (DATAR) was created as a framework to systemize and structure agrobiodiversity interventions under different scaling-up modalities for the on-the-ground field assessment and scaling-up of agrobiodiversity interventions. The use of the framework enabled the scaling up of small-scale interventions that use agrobiodiversity to have impact on agricultural development at larger spatial and temporal scales.
The Theoretical Background of Virtual Reality and Its Implications for the Tourism Industry
Authors: Polishchuk Elizaveta , Bujdosó Zoltán , El Archi Youssef , Benbba Brahim , Zhu Kai , Dávid Lóránt Dénes
Published: July 2023

Fueled by the Internet and artificial intelligence, virtual tourism represents an innovative integration of advanced technologies within the tourism industry. The 360 degree panoramic video has emerged as the most prevalent form of virtual tourism both domestically and internationally, owing to its affordability, ease of use, and mild impact. Nevertheless, the advent and proliferation of virtual reality (VR) has unlocked new opportunities in the tourism sector, as VR offers enhanced immersion and a more authentic user experience. Although VR is already employed in various capacities within the industry, it holds the potential to elevate virtual tourism to unprecedented heights. Diverging from prior research, this study examines virtual tourism as a distinct category of tourism that may materialize in the future. A focus group interview and a survey involving 243 respondents were conducted to gauge individuals’ receptiveness to virtual tourism. Participants responded to questions regarding their travel habits and their perceptions of virtual tourism. Data analysis revealed concerns surrounding the technological aspects of virtual tourism: over 20% of respondents were entirely unfamiliar with VR, and a mere 17% utilized the technology. A larger proportion, nearly 40%, lacked awareness of VR’s application in the tourism industry, and only 11.20% had personal experience with it. Concurrently, the Likert scale indicated that respondents recognized the advantages of virtual tourism in comparison to traditional travel, but they expressed skepticism about the technological advancements. Overall, most respondents displayed curiosity and a willingness to explore virtual tourism. These findings hold significant implications for both theoretical understanding and practical implementation within the tourism industry.
E-Bike Charging Infrastructure in the Workplace—Should Employers Provide It?
Authors: Kohlrautz David , Kuhnimhof Tobias
Published: July 2023

Constructing charging infrastructure for e-bikes at home or in other locations is necessary to enable motor support while riding. This paper focuses on charging facilities at work and study locations. It analyzes the charging frequency preference of 281 e-bike commuters who work or study at RWTH Aachen University, using survey data with 1091 choices for hypothetical free charging, as well as the same conditions for hypothetical paid charging. We use a mixed logit model to estimate the factors influencing the charging frequency, focusing on the commuting distance, an e-bike’s resale value, the age of the owner, student status, and employment group. One charging event per day can be expected for four e-bike commuters when free charging is available. In the case of paid charging, there is one charging event per 12 e-bike users. The magnitude of the reduction caused by a charging fee depends on group membership and, probably, on income. Commuting distance only has a statistically significant influence on the charging frequency when charging is free, raising the question of whether charging at work is necessary to cover trip chains that include stops at work. Owners of more expensive e-bikes charge less often, likely due to higher battery capacities, while the influence of age is inconclusive. However, providing charging infrastructure for employees and guests could be used as a low-cost measure to promote cycling among commuters.
A Model to Reduce Machine Changeover Time and Improve Production Efficiency in an Automotive Manufacturing Organisation
Authors: Niekurzak Mariusz , Lewicki Wojciech , Coban Hasan Huseyin , Bera Milena
Published: July 2023

One of the key postulates of the modern automotive industry is the increase in production efficiency while minimizing costs. In the opinion of experts from the automotive industry, meeting this condition may be the first stage on the way to preventing waste generation and implementing a circular economy model. The article presents a case study of issues related to the lean manufacturing methodology in terms of the impact of shortening the changeover time of the assembly line on the overall production efficiency. The presented considerations focus on the optimization of the production process using the SMED (Single Minute Exchange of Die) technique of a selected spare part. From the point of view of the Lean Manufacturing concept, the main goal of the SMED technique is to increase the flexibility of responding to changing customer needs by shortening the changeover times and faster responses to changing orders. The article describes the stages of implementing the SMED method and its impact on the increase in the OEE (Overall Equipment Efficiency) index, which allows for the percentage recognition of the degree of machine park utilization, which is one of the key factors for assessing energy efficiency. In addition, the benefits that have been achieved by using this method in terms of time and economy have been presented. The theoretical aspects related to the method used were supplemented with its practical implementation in order to improve the changeovers in a manufacturing company in the automotive industry. Based on the obtained test results, an analysis of the effectiveness of the measures taken to reduce the changeover time was carried out. The use of the SMED methodology contributed to a significant reduction in changeover time—by as much as 291.4 s. The burden on operators was significantly reduced—the total time and number of operations performed by them (both internal and external) was reduced. Operator paths have also been shortened using simple procedures such as changing the layout of the lines and modifying the changeover tool trolleys and tool locking system at the stations. The presented research may be helpful in answering the question whether the implementation of the SMED idea may be the key to effective resource management and, at a later stage, to the implementation of the circular economy model. In addition, the research results can find their practical application among both manufacturers of spare parts and the vehicles themselves, considering introducing process changes on their production lines in order to increase production efficiency and implementing the idea of industrial sustainability.
Robust Semi-Parametric Inference for Two-Stage Production Models: A Beta Regression Approach
Authors: Ospina Raydonal , Baltazar Samuel G. F. , Leiva Víctor , Figueroa-Zúñiga Jorge , Castro Cecilia
Published: July 2023

The data envelopment analysis is related to a non-parametric mathematical tool used to assess the relative efficiency of productive units. In different studies on productive efficiency, it is common to employ semi-parametric procedures in two stages to determine whether any exogenous factors of interest affect the performance of productive units. However, some of these procedures, particularly those based on conventional statistical inference, generate inconsistent estimates when dealing with incoherent data-generating processes. This inconsistency arises due to the efficiency scores being limited to the unit interval, and the estimated scores often exhibit serial correlation and have limited observations. To address such inconsistency, several strategies have been suggested, with the most well-known being an algorithm based on a parametric bootstrap procedure using the truncated normal distribution and its regression model. In this work, we present a modification of this algorithm that utilizes the beta distribution and its regression structure. The beta model allows for better accommodation of asymmetry in the data distribution. Our proposed algorithm introduces inferential characteristics that are superior to the original algorithm, resulting in a more statistically coherent data-generating process and improving the consistency property. We have conducted computational experiments that demonstrate the improved results achieved by our proposal.
Microorganisms and Biochar Improve the Remediation Efficiency of Paspalum vaginatum and Pennisetum alopecuroides on Cadmium-Contaminated Soil
Authors: Liang Jiahao , Chang Jiechao , Xie Jiayao , Yang Liquan , Sheteiwy Mohamed S. , Moustafa Abdel-Raouf A. , Zaghloul Mohamed S. , Ren Haiyan
Published: July 2023

Phytoremediation can help remediate potential toxic elements (PTE) in soil. Microorganisms and soil amendments are effective means to improve the efficiency of phytoremediation. This study selected three microorganisms that may promote phytoremediation, including bacteria (Ceratobasidium), fungi (Pseudomonas mendocina), and arbuscular-mycorrhizal fungi (AMF, Funneliformis caledonium). The effects of single or mixed inoculation of three microorganisms on the phytoremediation efficiency of Paspalum vaginatum and Pennisetum alopecuroides were tested under three different degrees of cadmium-contaminated soil (low 10 mg/kg, medium 50 mg/kg, and high 100 mg/kg). The results showed that single inoculation of AMF or Pseudomonas mendocina could significantly increase the biomass of two plants under three different degrees of cadmium-contaminated soil, and the growth-promoting effect of AMF was better than Pseudomonas mendocina. However, simultaneous inoculation of these two microorganisms did not show a better effect than the inoculation of one. Inoculation of Ceratobasidium reduced the biomass of the two plants under high concentrations of cadmium-contaminated soil. Among all treatments, the remediation ability of the two plants was the strongest when inoculated with AMF alone. On this basis, this study explored the effect of AMF combined with corn-straw-biochar on the phytoremediation efficiency of Paspalum vaginatum and Pennisetum alopecuroides. The results showed that biochar could affect plant biomass and Cd concentration in plants by reducing Cd concentration in soil. The combined use of biochar and AMF increased the biomass of Paspalum vaginatum by 8.9–48.6% and the biomass of Pennisetum alopecuroides by 8.04–32.92%. Compared with the single use of AMF or biochar, the combination of the two is better, which greatly improves the efficiency of phytoremediation.
First Experimental Survey of a Whole Class of Non-Commutative Quantum Gravity Models in the VIP-2 Lead Underground Experiment
Authors: Piscicchia Kristian , Marcianò Antonino , Addazi Andrea , Sirghi Diana Laura , Bazzi Massimiliano , Bortolotti Nicola , Bragadireanu Mario , Cargnelli Michael , Clozza Alberto , De Paolis Luca , Del Grande Raffaele , Guaraldo Carlo , Iliescu Mihail , Laubenstein Matthias , Manti Simone , Marton Johann , Miliucci Marco , Napolitano Fabrizio , Nola Federico , Porcelli Alessio , Scordo Alessandro , Sgaramella Francesco , Sirghi Florin , Doce Oton Vazquez , Zmeskal Johann , Curceanu Catalina
Published: July 2023

This study is aimed to set severe constraints on a whole class of non-commutative space-times scenarios as a class of universality for several quantum gravity models. To this end, slight violations of the Pauli exclusion principle—predicted by these models—are investigated by searching for Pauli forbidden Kα and Kβ transitions in lead. The selection of a high atomic number target material allows to test the energy scale of the space-time non-commutativity emergence at high atomic transition energies. As a consequence, the measurement is very sensitive to high orders in the power series expansion of the Pauli violation probability, which allows to set the first constraint to the “triply special relativity” model proposed by Kowalski-Glikman and Smolin. The characteristic energy scale of the model is bound to Λ>5.6·10−9 Planck scales.
In Silico Screening of Inhibitors of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine Protease
Authors: Hu Xin , Morazzani Elaine , Compton Jaimee R. , Harmon Moeshia , Soloveva Veronica , Glass Pamela J. , Garcia Andres Dulcey , Marugan Juan J. , Legler Patricia M.
Published: July 2023

The Venezuelan equine encephalitis virus (VEEV) nonstructural protein 2 (nsP2) cysteine protease (EC 3.4.22.B79) is essential for viral replication. High throughput in silico/in vitro screening using a focused set of known cysteine protease inhibitors identified two epoxysuccinyl prodrugs, E64d and CA074 methyl ester (CA074me) and a reversible oxindole inhibitor. Here, we determined the X-ray crystal structure of the CA074-inhibited nsP2 protease and compared it with our E64d-inhibited structure. We found that the two inhibitors occupy different locations in the protease. We designed hybrid inhibitors with improved potency. Virus yield reduction assays confirmed that the viral titer was reduced by >5 logs with CA074me. Cell-based assays showed reductions in viral replication for CHIKV, VEEV, and WEEV, and weaker inhibition of EEEV by the hybrid inhibitors. The most potent was NCGC00488909-01 which had an EC50 of 1.76 µM in VEEV-Trd-infected cells; the second most potent was NCGC00484087 with an EC50 = 7.90 µM. Other compounds from the NCATS libraries such as the H1 antihistamine oxatomide (>5-log reduction), emetine, amsacrine an intercalator (NCGC0015113), MLS003116111-01, NCGC00247785-13, and MLS00699295-01 were found to effectively reduce VEEV viral replication in plaque assays. Kinetic methods demonstrated time-dependent inhibition by the hybrid inhibitors of the protease with NCGC00488909-01 (Ki = 3 µM) and NCGC00484087 (Ki = 5 µM). Rates of inactivation by CA074 in the presence of 6 mM CaCl2, MnCl2, or MgCl2 were measured with varying concentrations of inhibitor, Mg2+ and Mn2+ slightly enhanced inhibitor binding (3 to 6-fold). CA074 inhibited not only the VEEV nsP2 protease but also that of CHIKV and WEEV.