bluuebunny/crossref_metadata_2025 huggingface dataset:
Intricate Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Isoforms in Normal Physiology and Disease
Authors: Seenappa Venu , Joshi Manjunath B. , Satyamoorthy Kapaettu
Published: April 2019

Background:

The phosphoenolpyruvate carboxykinase (PEPCK) isoforms are considered as rate-limiting enzymes for gluconeogenesis and glyceroneogenesis pathways. PEPCK exhibits several interesting features such as a) organelle-specific isoforms (cytosolic and a mitochondrial) in vertebrate clade, b) tissue-specific expression of isoforms and c) organism-specific requirement of ATP or GTP as a cofactor. In higher organisms, PEPCK isoforms are intricately regulated and activated through several physiological and pathological stimuli such as corticoids, hormones, nutrient starvation and hypoxia. Isoform-specific transcriptional/translational regulation and their interplay in maintaining glucose homeostasis remain to be fully understood. Mounting evidence indicates the significant involvement of PEPCK isoforms in physiological processes (development and longevity) and in the progression of a variety of diseases (metabolic disorders, cancer, Smith–Magenis syndrome).

Objective:

The present systematic review aimed to assimilate existing knowledge of transcriptional and translational regulation of PEPCK isoforms derived from cell, animal and clinical models.

Conclusion:

Based on current knowledge and extensive bioinformatics analysis, in this review we have provided a comparative (epi)genetic understanding of PCK1 and PCK2 genes encompassing regulatory elements, disease-associated polymorphisms, copy number variations, regulatory miRNAs and CpG densities. We have also discussed various exogenous and endogenous modulators of PEPCK isoforms and their signaling mechanisms. A comprehensive review of existing knowledge of PEPCK regulation and function may enable identification of the underlying gaps to design new pharmacological strategies and interventions for the diseases associated with gluconeogenesis.
Axonopathy Likely Initiates Neuropathological Processes Via a Mechanism of Axonal Leakage in Alzheimer's Mouse Models
Authors: Gao Ge , He Jing , Luo Yi , Sun Yan , Zhou Yanping , Zhang Junxia , Xing Ying , Dai Jiapei
Published: April 2019

Background:

The formation of hyperphosphorylated tau and the production of β-amyloid are thought to be critical steps contributing to the pathological mechanisms in Alzheimer’s disease (AD). However, there has been a long-lasting debate over their importance in the onset of AD. Recent studies have demonstrated that axonopathy is considered as an early neuropathological change of AD. However, the exact relationship between the development of axonopathy and the classic neuropathological changes such as senile plaques (SPs) and neurofibrillary tangles (NFTs) is unclear.

Objective:

The aim of this study was to investigate whether the formation of SPs and NFTs is associated with the development of axonal leakage.

Method and Results:

Here we show that the formation and development of axonal leakage - a novel axonopathy is an age-dependent process, accompanied by swellings of axons and varicosities and associated with chronic oxidative stress induced by thiamine deficient (TD) diet in Kunming mice. In an APP/PS1 transgenic mouse model of AD, axonal leakage appears at 3 months, becomes more obvious at 6 months and severe, beyond 1 year. We also show that slight axonal leakage is related to the formation of hyperphosphorylated tau, but not plaques, and that only severe axonal leakage accompanied by the extensive swollen axons and varicosities, and overproduction of β-amyloid leads to the formation of SPs and hyperphosphorylated tau.

Conclusion:

These data provide an explanation of the common origin and development of SPs and NFTs, and suggest that axonal leakage might be a key event in the development of the neuropathological processes in AD.
Brain Stimulation in Obsessive-Compulsive Disorder (OCD): A Systematic Review
Authors: Rapinesi Chiara , Kotzalidis Georgios D. , Ferracuti Stefano , Sani Gabriele , Girardi Paolo , Del Casale Antonio
Published: April 2019

Background:

Obsessive-compulsive disorder (OCD) is a highly prevalent, severe, and chronic disease. There is a need for alternative strategies for treatment-resistant OCD.

Objective:

This review aims to assess the effect of brain stimulation techniques in OCD.

Methods:

We included papers published in peer-reviewed journals dealing with brain stimulation techniques in OCD. We conducted treatment-specific searches for OCD (Technique AND ((randomized OR randomised) AND control* AND trial) AND (magnetic AND stimulation OR (rTMS OR dTMS)) AND (obsess* OR compuls* OR OCD)) on six databases, i.e., PubMed, Cochrane, Scopus, CINAHL, PsycINFO, and Web of Science to identify randomised controlled trials and ClinicalTrials.gov for possible additional results.

Results:

Different add-on stimulation techniques could be effective for severely ill OCD patients unresponsive to drugs and/or behavioural therapy. Most evidence regarded deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS), while there is less evidence regarding transcranial direct current stimulation (tDCS), electroconvulsive therapy, and vagus nerve stimulation (for these last two there are no sham-controlled studies). Low-frequency TMS may be more effective over the supplementary motor area or the orbitofrontal cortex. DBS showed best results when targeting the crossroad between the nucleus accumbens and the ventral capsule or the subthalamic nucleus. Cathodal tDCS may be better than anodal in treating OCD. Limitations. We had to include methodologically inconsistent underpowered studies.

Conclusion:

Different brain stimulation techniques are promising as an add-on treatment of refractory OCD, although studies frequently reported inconsistent results. TMS, DBS, and tDCS could possibly find some use with adequate testing, but their standard methodology still needs to be established.
Non-Alcoholic Fatty Liver Disease Treatment in Patients with Type 2 Diabetes Mellitus; New Kids on the Block
Authors: Athyros Vasilios G. , Polyzos Stergios A. , Kountouras Jiannis , Katsiki Niki , Anagnostis Panagiotis , Doumas Michael , Mantzoros Christos S.
Published: April 2019

Background:

Non-alcoholic fatty liver disease (NAFLD), affecting over 25% of the general
population worldwide, is characterized by a spectrum of clinical and histological manifestations ranging
from simple steatosis (>5% hepatic fat accumulation without inflammation) to non-alcoholic steatohepatitis
(NASH) which is characterized by inflammation, and finally fibrosis, often leading to liver cirrhosis,
and hepatocellular carcinoma. Up to 70% of patients with type 2 diabetes mellitus (T2DM) have
NAFLD, and diabetics have much higher rates of NASH compared with the general non-diabetic population.

Objective:

The aim of this study is to report recent approaches to NAFLD/NASH treatment in T2DM
patients. To-date, there are no approved treatments for NAFLD (apart from lifestyle measures).

Results:

Current guidelines (2016) from 3 major scientific organizations suggest that pioglitazone and
vitamin E may be useful in a subset of patients for adult NAFLD/NASH patients with T2DM. Newer
selective PPAR-γ modulators (SPPARMs, CHRS 131) have shown to provide even better results with
fewer side effects in both animal and human studies in T2DM. Newer antidiabetic drugs might also be
useful, but detailed studies with histological outcomes are largely lacking. Nevertheless, prior animal
and human studies on incretin mimetics, glucagon-like peptide-1 receptor agonists (GLP-1 RA) approved
for T2DM treatment, have provided indirect evidence that they may also ameliorate
NAFLD/NASH, whereas dipeptidyl dipeptidase-4 inhibitors (DDP-4i) were not better than placebo in
reducing liver fat in T2DM patients with NAFLD. Sodium-glucoseco-transporter-2 inhibitors (SGLT2i)
have been reported to improve NAFLD/NASH. Statins, being necessary for most patients with T2DM,
may also ameliorate NAFLD/NASH, and could potentially reinforce the beneficial effects of the newer
antidiabetic drugs, if used in combination, but this remains to be identified.

Conclusion:

Newer antidiabetic drugs (SPPARMs, GLP-1 RA and SGLT2i) alone or in combination
and acting alone or with potent statin therapy which is recommended in T2DM, might contribute substantially
to NAFLD/NASH amelioration, possibly reducing not only liver-specific but also cardiovascular
morbidity. These observations warrant long term placebo-controlled randomized trials with appropriate
power and outcomes, focusing on the general population and more specifically on T2DM with
NAFLD/NASH. Certain statins may be useful for treating NAFLD/NASH, while they substantially
reduce cardiovascular disease risk.
Advances in Dermoepidermal Skin Substitutes for Diabetic Foot Ulcers
Authors: Álvaro-Afonso Francisco Javier , García-Álvarez Yolanda , Lázaro-Martínez Jose Luis , Kakagia Despoina , Papanas Nikolaos
Published: April 2019

Diabetic foot ulcers (DFUs) are one of the major complications of diabetes, representing a leading cause of hospitalisation and non-traumatic lower limb amputations. Multidisciplinary management, patient education, glucose control, debridement, off-loading, infection control, and adequate perfusion are the mainstays of standard care. Despite all these, at least 30% of DFUs fail to heal within 20 weeks. Therefore, dermoepidermal skin substitutes (DSS) have been used as a new therapeutic adjunct for DFUs. This brief review outlines the recent advances in DSS for the treatment of DFUs. PubMed and Cochrane databases were systematically searched in May to July 2018 for systematic reviews published after 2013 and for randomised controlled trials (RCTs). A retrospective evaluation of 28 RCTs was performed. Rates of complete wound closure and time to healing were examined for 17 commonly available DSS. Healing rates after 12 weeks and time to complete closure in DFUs are heterogeneous among the 28 RCT. The best healing rates at 12 weeks were accomplished with dermal cellular substitutes (Epifix®, 100% and Amnioband®, 85%) and with dermal acellular substitutes (Allopatch®, 80% and Hyalograft®, 78.8%). Based on these studies, DSS used in conjunction with standard care appear to improve the healing rates of DFUs, as compared with standard care alone. Nonetheless, new studies with more homogeneous samples are needed to ascertain the role of ulcer size, duration, depth and/or type in the efficacy of DSS. Moreover, future RCTs should include patients with severe comorbidities, in order to be more representative of clinical reality.
Study of Possible Relation between Fasting Plasma Glucagon, Gestational Diabetes and Development of Type 2 DM
Authors: Okba Ashraf , Hosny Salwa Seddik , Elsherbeny Alyaa , Kamal Manal Mohsin
Published: April 2019

Background and Aims:

Women who develop GDM (gestational diabetes mellitus) have a
relative insulin secretion deficiency, the severity of which may be predictive for later development of
diabetes. This study aimed to investigate the role of fasting plasma glucagon in the prediction of later
development of diabetes in pregnant women with GDM.

Materials and Methods:

The study was conducted on 150 pregnant women with GDM after giving
informed oral and written consents and being approved by the research ethical committee according to
the declaration of Helsinki. The study was conducted in two phases, first phase during pregnancy and
the second one was 6 months post-partum, as we measured fasting plasma glucagon before and after
delivery together with fasting and 2 hour post-prandial plasma sugar.

Results:

Our findings suggested that glucagon levels significantly increased after delivery in the majority
14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared
to 6/20 (30%) patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) non
DM women, as the median glucagon levels were 80,76, 55, respectively. Also, there was a high statistical
difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic
women (p ≤ 0.001). These results indicated the useful role of assessing fasting plasma glucagon before
and after delivery in patients with GDM to predict the possibility of type 2 DM.

Conclusion:

There is a relatively high glucagon level in GDM patients, which is a significant pathogenic
factor in the incidence of subsequent diabetes in women with a history of GDM. This could be
important in the design of follow-up programs for women with previous GDM.
Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors
Authors: Li Song-Ye , Zhang Ting-Jian , Wu Qing-Xia , Olounfeh Kamara M. , Zhang Yi , Meng Fan-Hao
Published: April 2019

Background:

Topiroxostat is an excellent xanthine oxidase (XO) inhibitor, possessing a
specific 3,5-diaryl-1,2,4-triazole framework.

Objective:

The present work was aimed to investigate the preliminary structure-activity relationship
(SAR) of 2-cyanopyridine-4-yl-like fragments of topiroxostat analogues.

Methods:

A series of 5-benzyl-3-pyridyl-1H-1,2,4-triazole derivatives (1a-j and 2a-j) were designed
and synthesized by replacement of the 2-cyanopyridine-4-yl moiety with substituted benzyl
groups. XO inhibitory activity in vitro was evaluated. Furthermore, molecular modeling simulations
were performed to predict the possible interactions between the synthesized compounds and
XO binding pocket.

Results:

The SARs analysis demonstrated that 3,5-diaryl-1,2,4-triazole framework is not essential;
in spite of its lower potency, 5-benzyl-3-pyridyl-1H-1,2,4-triazole is an acceptable scaffold for XO
inhibitory activity to some extent. A 3′-nitro and a 4′-sec-butoxy group link to the benzyl moiety
will be welcome. Furthermore, the most promising compound, 1h, was identified with an IC50
value of 0.16 μM, and the basis of XO inhibition by 1h was rationalized through the aid of molecular
modelling studies.

Conclusion:

Compound 1h could be a lead compound for further investigation and the present
work may provide some insight into the search for more structurally diverse XO inhibitors with
topiroxostat as a prototype.
New Insights in Design and Development of Antitubercular Drugs
Authors: Yadav Snehlata , Narasimhan Balasubramanian
Published: April 2019

Background:

Tuberculosis, an infectious disease caused mainly by the Mycobacterium
tuberculosis accounts for the highest number of deaths worldwide. Despite curing millions, the currently
used drug regimens are bounded by various limitations such as long course of therapy, emergence of
resistance and permanent tissue damage. The treatment of multidrug-resistant and extremely drugresistant
tuberculosis is a challenging task due to its reliance on second-line drugs which are less potent
and more toxic than those used in the clinical management of drug-susceptible tuberculosis. Therefore,
the major challenges in the upcoming years are to overcome the emergence of increased number of
multidrug-resistant as well as extensively drug-resistant strains and the ineptness of the current treatment
regimens against latent tuberculosis. Bedaquiline and Delamanid are the only new anti-TB drugs
that have been currently approved since more than 40 years after discovery of isoniazid. Bedaquiline is
the first diarylquinoline derivative that has showed resilient culture conversion at 24 weeks in phase IIb
trials.

Methods:

Extensive literature search on the topic was undergone using a focused question.

Results:

Fifty-eight research articles from journals of repute are included in the review. The vaccine and
peptide-based conjugates are recent developments against Mycobacterium for selective and specific
targeting to the desired tissues.

Conclusion:

In this review, we have focused on the different classes of chemical as well as plant based
compounds as potent antitubercular agents against multidrug-resistant tuberculosis strains. This review
falls light on the importance of research been undergoing in different parts of the world to combat the
ever increasing problem of mycobacterial resistance and the various treatment options available for the
treatment of tuberculosis.
Comparison of Different Extraction Methods for the Phenolic Compounds Recovery with the Antioxidant Activity of Bougainvillea x buttiana
Authors: Abarca-Vargas Rodolfo , Petricevich Vera L.
Published: April 2019

Background:

Bougainvillea x buttiana has long been used as a Mexican conventional medicinal
drug to cure different sicknesses.

Objective:

In this work, the consequences of ethanol combination and temperature extraction for
phenolic compound recovery with the biological activity in Bougainvillea x buttiana extracts were
investigated.

Materials and Methods:

The phenolic recovery from Bougainvillea x buttiana was determined by
comparing the effects of ethanol 0%, 50-100% (v/v) and extraction temperature (26, 45 and 64°C).
The total phenolic content was investigated using spectrophotometric methods. Antioxidant activity
from different Bougainvillea x buttiana extracts was evaluated by determining their potential to scavenge
the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. The chemical compositions and cytotoxic
effect of extracts were determined using GC-MS techniques and the crystal violet technique,
respectively.

Results:

Our results confirmed that all extractions with different concentrations and temperatures had
significant effects over the total phenolic contents and antioxidant activity (DPPH) of the extracts.
The best recuperation of the total phenol content was observed in extracts with 60% ethanol at 26°C
(201.08 mgEGA/g dry extract). Extracts with 100% ethanol at 26°C showed the highest antioxidant
activity (IC50 was 286.75 μg/mL). GC-MS revealed the presence of various phytochemical contents
with polar and non-polar properties. The phenolic compounds were investigated as to the structure,
quantity and position of the hydroxyl groups on the benzene ring.

Conclusion:

The ethanolic extract of Bougainvillea x buttiana was confirmed to have high phenolic
content and contain pharmacologically active compounds, with potent antioxidant effects and low cytotoxic
effects.
Triphenylethylene-Coumarin Hybrid TCH-5c Suppresses Tumorigenic Progression in Breast Cancer Mainly Through the Inhibition of Angiogenesis
Authors: Cui Naipeng , Lin Dan-Dan , Shen Yang , Shi Jian-Guo , Wang Bing , Zhao Ming-Zhi , Zheng Lishuang , Chen Hua , Shi Jian-Hong
Published: April 2019

Background:

Coumarins are a wide group of naturally occurring compounds which exhibit a wide range
of biological properties such as anti-cancer activities. Here, we characterized the biological functions of three
Triphenylethylene-Coumarin Hybrids (TCHs) both in cell culture and nude mouse model.

Methods:

Cell proliferation assay was performed in the cell cultures of both EA.hy926 endothelial cell and breast
cancer cell lines treated with different concentrations of compound TCH-10b, TCH-5a and TCH-5c. Flowcytometry
assay and Western blotting were used to further investigate the effect and mechanism of TCH-5c on EA.hy926
cell proliferation and cell cycle. The effects of TCH-5c on endothelial cell migration and angiogenesis were determined
using cytoskeleton staining, migration assay and tube formation assay. Inhibition of breast cancer cell line
derived VEGF by TCH-5c was shown through ELISA and the use of conditioned media. SK-BR-3 xenograft mouse
model was established to further study the anti-tumorigenic role of compound TCH-5c in vivo.

Results:

We found that compound TCH-5c has inhibitory effects on both vascular endothelial cells and breast cancer
cell lines. Compound TCH-5c inhibited proliferation, resulted in cell death, increased p21 protein expression to
induce G0/G1 arrest and changed endothelial cell cytoskeleton organization and migration in EA.hy926 endothelial
cells. Compound TCH-5c also inhibited breast cancer cell line derived VEGF secretion, decreased breast cancer
cell-induced endothelial cell tube formation in vitro and suppressed SK-BR-3 breast cancer cell-initiated tumor
formation in vivo.

Conclusion:

Our study demonstrates that the coumarin derivative TCH-5c exerts its anti-cancer effects by 1. inhibiting
endothelial cell proliferation, migration. 2. suppressing tube formation and angiogenesis induced by breast
cancer cells in vitro and in vivo. Our results have potential implications in developing new approaches against breast
cancer.
Novel Thiazine Substituted 9-Anilinoacridines: Synthesis, Antitumour Activity and Structure Activity Relationships
Authors: Kalirajan R. , Gaurav K. , Pandiselvi A. , Gowramma B. , Sankar S.
Published: April 2019

Background:

9-anilinoacridines are acting as DNA-intercalating agents which plays an important
role as antitumor drugs, due to their anti-proliferative properties. Some anticancer agents contain 9-
anilinoacridines such as amsacrine (m-AMSA), and nitracrine (Ledakrine) have been already developed.

Methods:

In this study, novel 9-anilinoacridines substituted with thiazines 4a-r were designed, synthesized,
characterized by physical and spectral data and their cytotoxic activities against DLA cell lines were evaluated.

Results:

Among those compounds, 4b, c, e, g, i, j, k, m, o, p, q, r exhibited significant short term in vitro cytotoxic
activity against Daltons lymphoma ascites (DLA) cells with CTC50 value of 0.18 to 0.31μM. The compounds
4b, c, e, g, i, j, k, m, o, p, q, r are also exhibited significant long term in vitro anti-tumour activity
against human tumor cell lines, HEp-2 (laryngeal epithelial carcinoma) by Sulforhodamine B assay with CTC50
value of 0.20 to 0.39μM. The compounds 4b, i, j exhibited significant in vivo antitumor activity with % Increase
in Life Span (ILS) 48-82%.

Conclusion:

Results obtained in this study clearly demonstrated that many of the thiazine substituted 9-
anilinoacridines exert interesting anti-tumour activity. The compounds 4b, i, j have significant anti-tumour
activity and useful drugs after further refinement. The above derivatives will encourage to design future antitumor
agents with high therapeutic potentials.
Fluoroquinolones and the Risk of Aortic Aneurysm or Aortic Dissection: A Systematic Review and Meta-Analysis
Authors: Rawla Prashanth , El Helou Marie Line , Vellipuram Anantha R.
Published: April 2019

Objective:

We performed a systematic review and meta-analysis to explore the risk of an
aortic aneurysm or aortic dissection following fluoroquinolone administration.

Methods:

PubMed, Cochrane library, ClinicalTrials.gov, Embase and Google Scholar were systematically
reviewed for controlled studies including adult patients exposed to fluoroquinolones with a
primary outcome of aortic aneurysm or aortic dissection.

Results:

The meta-analysis was conducted by pooling the effect estimates of four controlled observational
studies (one case-control, one case-crossover and two cohort studies). Fluoroquinolone administration
more than doubled the risk to develop aortic aneurysm or aortic dissection within 60 days
following fluoroquinolone exposure (adjusted Relative Risk [RR] (95% confidence interval [CI]) =
2.14 (1.93 - 2.36); I2 = 15.8%). The quality of the finding was rated as moderate.

:

The risk increase for aortic aneurysm alone was found to be significant (adjusted RR (95% CI) =
2.23 (2.01 - 2.45); I2 = 0%) while the risk increase for aortic dissection alone was not found to be
significant (adjusted RR = 1.88 (0.11 - 3.65); I2 = 74%).

:

In subgroup analysis, the risk increase for aortic aneurysm or aortic dissection appeared to be higher
in females compared to males (RR = 1.87 (1.24 - 2.51); I2 = 0% versus RR = 1.58 (1.25 - 1.92); I2 =
0%, respectively) and higher in older patients compared to younger patients (RR = 1.72 (1.37 - 2.07);
I2 = 0% versus RR = 1.47 (0.91 - 2.04); I2 = 0%, respectively).

:

Subgroup analysis of two studies which measured the duration-response analysis found that as the
duration of fluoroquinolone therapy increased from 3 to 14 days to greater than 14 days, there was an
increased risk of aortic aneurysm or dissection.

Conclusion:

The findings of this meta-analysis confirm the positive association between fluoroquinolones
and the development of aortic aneurysm or dissection. The data tend to show that this association
may be majorly driven by aortic aneurysm. Additionally, some risk factors appear to prevail including
prolonged fluoroquinolone treatment and older age.
Evaluation of hs-CRP and sLOX-1 Levels in Moderate-to-High Risk Acute Coronary Syndromes
Authors: Çoner Ali , Aydınalp Alp , Müderrisoğlu Haldun
Published: April 2019

Objective:

Risk stratification and prompt treatment are essential for the management of
acute coronary syndromes (ACS) and prediction of future prognosis. Subclinical vascular inflammation
and novel biomarkers play an important role in the clinical evaluation of ACS patients.

Methods:

We enrolled patients who were admitted to emergency service with unstable angina or non-
ST segment elevated ACS (NSTE-ACS) in the study population. Coronary artery disease (CAD) complexity
was determined via evaluation of angiographical views and peripheral venous blood samples
were collected to measure highly sensitive C-reactive protein (hs-CRP) and soluble form of Lectin-like
OxLDL receptor-1 (sLOX-1) levels.

Results:

A total of 40 patients were enrolled in the study population, mean age was 65.1±13.8 years
and male gender percentage was 52.5%. Twenty-nine of patients had NSTE-ACS and 11 patients had
unstable angina presentation. The modified Gensini scores were higher for patients with elevated hs-
CRP and sLOX-1 levels.

Conclusion:

Vascular inflammation displays the onset of ACS and it is related to more complex CAD
in these patients. An increase in sLOX-1 expression is closely related to anatomical complexity of
CAD in ACS..
WSN Based Embedded System for Field Parameter Monitoring Inside a Low-Cost Polyhouse
Authors: Goswami Manash Protim , Hazarika Sudipta , Bora Durlove , Sarma Utpal
Published: April 2019

Background & Objective::

This paper presents a wireless sensor network for monitoring
field parameters inside a low-cost polyhouse. The micro climate inside a polyhouse differs from that
on the outside, which provides a favorable condition for unseasonal crops.

Methods:

The physical parameters associated with the polyhouse’s microclimate were monitored by
a reliable low-cost wireless sensor network, which in turn helps to take decisions for enhancing yield
quality and quantity. Sensor network development, signal conditioning, calibration of the soil temperature
measurement system and field experience of the installed system are discussed in this paper.
The field parameters for the growing period of cucumber (Cucumis sativus) inside the polyhouse are
provided in the paper.

Results & Conclusion:

It showed significant variations in temperature, relative humidity and wind
speed inside the polyhouse to that of the outside. It was also observed that soil temperature, soil
moisture in mulched soil differed from that of the open condition. Enhancement of the crop yield was
found for mulched soil.
Design and Development of MEMS Sensors Based Inertial Navigation Systems for Aerial Vehicles: A Case Study
Authors: Kaur Amanpreet , Mantri Archana , Kumar Vipan
Published: April 2019

Background & Objective:

MEMS sensors are rapidly growing as a sensing technology in
all spheres of science and engineering. MEMS technology is playing an important role in avionics for
miniaturization of systems and MEMS based Inertial Navigation System (INS) is one of the example.
The situational awareness and performance of an aerial vehicle is computed with the help of an INS.
This paper describes the case study for design of MEMS based low cost rugged INS for aerial vehicles.
The 9 Degrees of Freedom (DOF) that are obtained from the sensors provide an inaccurate attitude
information of aerial vehicles due to presence of external accelerations and the gyroscopic drifts
in MEMS sensors. In order to overcome such problems and for the precise and reliable computation
of orientation information, the error characteristics of accelerometers, magnetometers and gyroscopes
have been combined into a sensor fusion algorithm with ‘Kalman Filter’ to compute the accurate orientation
information. The processing has been done on STM32F407VGT6 microcontroller board. An
accuracy of ± 0.1 degrees is achieved for Roll and Pitch and ± 1.0 degrees for Yaw have been obtained.
The experimental results have been obtained in statically (keeping the device in a static position)
and dynamically (rotating the device at different angles along roll, pitch and yaw axis) at room
temperature of 22°C.

Methods:

The design is different in a way that it has used a unique combination of trio MEMS sensors
network consisting of FXOS8700CQ Accelerometer, FXAS21000 Gyroscope, FXOS8700CQ
Magnetometer.

Results:

The attitude estimation algorithm has been implemented on the 32-bit microcontroller. The information
data is processed and displayed on 88.9 mm TFT-LCD through Graphical User Interface (GUI).
Audio Watermarking Art of Hiding Copyright Information for Piracy Control
Authors: Tewari Tribhuwan Kumar
Published: April 2019

Background & Objective:

Revolution in digital multimedia is a boon to music industries,
music creators for decades as digital music can be created, stored replicated and transferred easily
and efficiently. But digitalization of multimedia becomes a curse when the multimedia content is illegally
and freely distributed, shared across the network online or offline. Countering the illegal copying
and distribution of digital media is the driving force behind the evolution of copyright protection
and digital watermarking techniques.

Methods:

This paper presents the problem of piracy and the overview of the evolution of different
digital audio watermarking techniques in time, transformed and compression domains to counter the
problem of music piracy. The limitations of the audio watermarking techniques and the future scope
for improvement are also presented.

Results & Conclusion:

This paper summarizes the evolution of audio watermarking techniques and reviews
the existing watermarking techniques applied on audios. The limitations of the audio watermarking
techniques and the future scope for improvement are also proposed. Additionally, the preliminaries
for audio and brief of the properties which are exploited for watermarking of audio are presented.
Primeros registros del Chipe dorado Protonotaria citrea (Aves: Passeriformes) en el estado de Puebla, México
Authors: Jiménez Moreno Francisco Javier , Duchateau Arturo , González Oreja José Antonio
Published: April 2019

Durante la temporada de reproducción, el Chipe dorado (Protonaria citrea) se puede encontrar desde el este de Estados Unidos y Canadá, mientras que en invierno se extiende desde el sur de México hasta América Central y el Caribe. Se ha reportado a esta especie como transitoria en el Eje Neovolcánico Transversal. En esta nota informamos sobre los dos primeros registros de la especie en el estado de Puebla, México. El 18 de abril de 2017, observamos un macho en la ex Hacienda de Chautla (19°18´55´´ N, 98°28´15´´ O) y una hembra en el Parque Ecológico “Revolución Mexicana” (19°01´47´´ N, 98°11´08´´ O) en la ciudad de Puebla. Nuestros datos, y los registros previos de la especie en la Ciudad de México, podrían sugerir que el Chipe dorado puede aprovechar las condiciones ambientales y/o recursos naturales asociados con los ecosistemas urbanos modernos. Por otro lado, estos registros también podrían ser el resultado del creciente interés por las actividades de observación de aves en entornos urbanos. Se requieren más trabajos de campo para mejorar nuestro conocimiento de la distribución del Chipe dorado en México y determinar si es un migrante transitorio en Puebla o puede considerarse un residente de invierno.
La neurociencia cognitiva en la formación inicial de docentes Investigadores Educativos
Authors: Lozoya Meza Esperanza , Amaya Gutiérrez Susana , Lozoya Ocegueda Rebeca
Published: April 2019

La neurociencia estudia de manera interdisciplinaria el cerebro y ha augurado un cambio de paradigma en el campo educa­tivo. Es así que la neuroeducación, al permitir que el maestro entienda las particularidades del sistema nervioso y del cerebro y, a la vez, relacione este conocimiento con el comportamien­to de sus alumnos, su propuesta de aprendizaje, su actitud y el ambiente del aula, puede ser el paso inicial en la formación y capacitación docente que marcará la diferencia en la calidad de la educación (Campos, 2010). El objetivo de este trabajo es desarrollar un acercamiento al estudio del estado del arte de la neurociencia cognitiva enfocada a la neuroeducación y vin­culada a la formación inicial de docentes-investigadores. La metodología que se siguió fue deductiva e incluye la lectura y análisis de documentos que posibilitan la construcción de un lenguaje común, con relación a los temas y conceptos vincula­dos con el objeto de estudio.
GOVERNANÇA E PLANEJAMENTO DE TECNOLOGIA DA INFORMAÇÃO: UM ESTUDO EXPLORATÓRIO DA PRODUÇÃO STRICTO SENSU NO BRASIL ENTRE 1995 e 2014
Authors: Magalhães Fábio Luís Falchi de , Ohashi Fábio Kazuo , Silva Lidiane Cristina da , Gaspar Marcos Antonio , Cardoso Marcos Vinicius
Published: April 2019

O objetivo desta pesquisa é o de explorar a produção científica no Brasil sobre a temática governança e planejamento de TI, a partir das dissertações e teses publicadas no país provenientes de cursos de pós-graduação stricto sensu, no período de 1995 a 2014. Esta temática se destacou em 2012 como uma das maiores preocupações da gestão nas organizações no mundo segundo a ‘Society for Information Management’. É realizada uma pesquisa descritiva documental com a utilização da bibliometria, tendo como base de dados à plataforma CNPq Lattes. Foram identificados 263 trabalhos, sendo 34 (D), 160 (ME) e 69 (MP). Com 259 egressos, 104 programas em 67 diferentes IES e 176 orientadores, mais da metade dos trabalhos são oriundos de programas de excelente qualidade (sem MP). Maioria das instituições e pesquisadores, igualmente participando em congressos científicos específicos refletindo avanço na área. IES particulares sem fins lucrativos, o Sudeste, o estado de São Paulo, a Universidade Católica de Brasília (UCB) e João Souza Neto foram os mais profícuos. A temática analisada tem sido assunto de interesse de pesquisa, notadamente pelo pleno crescimento no decorrer do período analisado, com destaque para o ano 2012 e categoria temática governança de TI. Metade dos estudos tem sido realizada na área da Administração, Ciências Contábeis e Turismo, mas também se verificou a ocorrência de trabalhos nas áreas: Engenharias III, Interdisciplinar, Ciência da Computação e Engenharias IV, entre outras, de um total de dez das 48 áreas de avaliação da CAPES.
A Chape e a Nova Arena Condá: Sonho ou Realidade?
Authors: Souza Everaldo de , Leite Leandro , Seemann Jacqueline dos Santos
Published: April 2019

A Chape – Associação Chapecoense de Futebol foi fundada em 1973 e ficou conhecida mundialmente no final de 2016 pelo acidente aéreo que vitimou praticamente todo o time. Em sete anos, subiu as quatro divisões nacionais e conseguiu ir à final da Copa Sul-Americana. Atualmente é o mais bem estruturado time de futebol da região oeste de Santa Catarina. Além dos excelentes resultados em campo nos últimos anos, o clube apresentava resultados financeiros satisfatórios. Rosa Maria é gerente administrativa do Clube há mais de dez anos e acompanhou esse cenário de crescimento e conquistas, inclusive o sonho da construção da nova Arena Condá. Porém, o time com o acidente aéreo no final de 2016, teve que se reorganizar para seu retorno aos campeonatos. Neste mesmo período realizou ações para a ampliação de patrocinadores. Paralelamente, processos trabalhistas e judiciais contra o clube foram iniciados pelas vítimas e seus familiares. À Rosa Maria foi solicitado um parecer administrativo-financeiro sobre a atual situação do clube, sugerindo a viabilidade de investimento da Nova Arena Condá. A proposta deste caso para ensino é analisar a viabilidade sobre o investimento da nova Arena Condá, considerando suas análises administrativas-financeiras, os novos patrocinadores, os processos judiciais e as possíveis formas de viabilização e de manutenção deste empreendimento. Poderá ser trabalhado em níveis de graduação e pós graduação nas áreas de gestão e negócios, em disciplinas de administração financeira e de investimentos. Poderá também ser aplicada na análise de balanços, estratégias empresariais e financeira.
A produção científica sobre as teorias na administração pública brasileira: uma análise dos periódicos no período de 2006 a 2017
Authors: Nascimento Raimunda Letícia do , Santos Ana Sara Leite , Cabral Augusto Cézar de Aquino , Santos Sandra Maria dos , Pessoa Maria Naiula Monteiro
Published: April 2019

Este artigo tem como objetivo principal analisar a produção científica sobre as teorias na administração pública brasileira. Sua relevância é a de fornecer um mapeamento das publicações na área de administração pública brasileira nos últimos 11 anos, que permitirá fazer um diagnóstico da área no período, comparar com estudos anteriores e fornecer perspectivas para os pesquisadores e demais interessados na área. Trata-se de um estudo exploratório-descritivo com abordagem quantitativa, utilizando o método de pesquisa bibliométrico. Os procedimentos técnicos são documentais com consulta aos periódicos indexados na base de dados SPELL (Scientific Periodicals Eletronic Library) no período de 2006 a 2016. Observou-se que a produção acadêmica em teorias da administração pública brasileira cresceu no período; os pesquisadores estão concentrados na região sudeste; os temas mais abordados são gestão pública e gestão social; as teorias mais utilizadas são as que pertencem à corrente da nova administração pública; o setor mais estudado são as instituições de ensino; e as pesquisas são empíricas, de abordagem qualitativa, de natureza descritiva, predominando o método estudo de caso.
ACEITAÇÃO E USO DO SISTEMA INTEGRADO DE PATRIMÔNIO, ADMINISTRAÇÃO E CONTRATOS (SIPAC) NO INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIAS E TECNOLOGIA DE ALAGOAS (IFAL): UMA ANÁLISE DAS DIFERENÇAS DE GRUPOS
Authors: Cavalcante Gesualdo Menezes , Ceolin Alessandra Carla , Barros José Eduardo de Melo
Published: April 2019

Este estudo buscou identificar possíveis diferenças de grupos moderadores nos construtos da Teoria Unificada de Aceitação e Uso da Tecnologia (UTAUT) em relação à aceitação e uso do sistema SIPAC no IFAL. A metodologia utilizada foi um estudo de caso de natureza exploratória e descritiva, com abordagem quantitativa. Aplicou-se questionários baseados na Teoria UTAUT de Venkatesh et al. (2003) aos servidores lotados na Pró-Reitoria de Administração. A coleta ocorreu no mês de novembro de 2017 e 41 servidores (83,7% do total) participaram da pesquisa. Para a análise dos resultados, utilizou-se estatísticas descritivas e análise inferencial através de testes não paramétricos de Mann Whitney. Os testes de Mann Whitney, onde foram considerados (P<0,05) de significância, de forma geral, apresentaram poucas diferenças significativas. As principais diferenças encontradas foram: evidenciou-se uma maior compreensão para servidores do sexo masculino de que a instituição oferece condições e infraestrutura necessárias para o uso do SIPAC; que as assistências técnicas são diferentes entre as áreas investigadas, especialmente quando há dificuldades com o sistema SIPAC, e também que os usuários com menor tempo de uso com sistemas (até 5 anos) são os que mais têm recebido apoio da instituição e de seus superiores, em relação ao tempo de uso com o sistema SIPAC. Além dos fatores anteriores, constatou-se que os servidores como mais tempo de uso do sistema possuem maior facilidade na sua operação, utilizam o sistema com maior rapidez e tem maior produtividade no trabalho.
THE INFLUENCE OF THE LIMITATION OF ATTENDANCE OF PATIENTS WITH HIV-INFECTION, COMBINED WITH TUBERCULOSIS, AIDS CENTER POLYCLINICS TO THE FREQUENCY OF CONTAMINATION BY MYCOBACTERIA OF THE HOSPITAL FACILITY ENVIRONMENT
Authors: Sergevnin V. I. , Sarmometov E. V. , Tukacheva O. V. , Mikova O. E.
Published: April 2019

The attendance of patients with HIV infection, combined with tuberculosis, of different medical organizations was studied before and after limiting service of patients with co-infection in the AIDS center polyclinic. 163 flushes from the hospital environment of the AIDS centre polyclinic were studied by polymerase chain reaction for the presence of tuberculosis mycobacteria DNA. It was established that a decrease in the number of visits to a specialized polyclinic by the patients with HIV infection combined with tuberculosis was accompanied by a decrease in the degree of hospital facility environment contamination by tuberculosis mycobacteria.
EPIDEMIOLOGY OF HIV INFECTION IN THE AMUR REGION
Authors: Turkutyukov V. B. , Lipskaya N. A. , Natykan Yu. A. , Pavlova I. I. , Glebova N. A. , Bazykina E. A.
Published: April 2019

The HIV infection prevalence rate suggests that in the Russian Federation the number of new cases of infection continues to grow. The retrospective epidemiological analysis of HIV infection in the Amur region was performed during a 5-year period from 2013 to 2017. The study included evaluation of incidence and prevalence rates, morbidity and mortality patterns. A positive HIV status has 0,14% of the region population. In 2017, the HIV-incidence rate equaled to 10,97‰00. Similar incidence rates were registered during 2015 and 2016. During 2013–2017 annual growth of HIV-prevalence that reached its peak in 2017 and exceeded the previous year’s rate at 18,3±0,65% (p=0,001) was registered. The highest HIV prevalence was detected at age from 30 to 39 years (45%). Among the HIV-positive people, sexual transmission route was dominant and during 2017 and totaled to 87%. Among people living with HIV registered for outpatient treatment, the most frequent stages of the disease (representing 97,7% of all clinical forms) were subclinical stage diagnosed in 251,3‰ [95% CI 232,2–270,3] and second stage (of secondary manifestations) totaled to 216,1‰ [95% CI 191,5–240,5]. This indicates on the development of the concentrated stage of HIV infection in the Amur region. Epidemiologic features of infection spread in the Amur region derives not only from active cross-border movements of citizens, but also from the specifics of demography processes.
CONTROL AND QUALITY OF PILES BY NON-DESTRUCTIVE EXPRESS METHODS: LOW STRAIN METHOD AND CROSS-HOLE SONIC LOGGING
Authors: Zhussupbekov Askar , Iwasaki Yoshinori , Shakirova Nurgul , Chul Shin Eun
Published: April 2019

This paper described using Low Strain Method and Cross-Hole Sonic logging (CSL) for identify of integrity of bridge foundations of LRT in Astana, Kazakhstan. The CSL is a method prescribed by ASTM D6760 - 08, Standard Test Method for Integrity Testing of Concrete Deep Foundations. This method is considered to be more accurate than sonic echo testing in the determination of soundness of concrete. The sonic access tubes do not contribute to the structural capacity of the pile. The bored piles of LRT are 1.0^1.5 m of diameters and 10^55 m of lengths. Design bearing capacity of piles is more than 4500 kN. At the testing period were founded defects in foundation bodies. To check of integrity were conducted by static load tests. The CSL test is based on the length of time for an ultrasonic wave to be propagated between any two of the selected tubes. The velocity of the propagated wave depends on the material through which the wave is transmitted. The aim of this paper is to discuss the advantages and disadvantages of Low Strain Method and CSL methods by analysis of field testing. For checking integrity applying two methods - Low Strain Method and Cross-Hole Sonic Logging. The aim of this paper is to discuss the advantages and disadvantages of each method using the examples of a real application.
THE METHOD OF LOCAL AUTOMATIC CONTROL OF THERMOPHYSICAL PARAMETERS OF EXTERNAL WALLS OF BUILDINGS AT THE LOCATIONS OF CONDENSATE LOSS
Authors: Fedosov Sergej , Mureev Pavel , Kotlov Vitalij , Makarov Aleksandr , Ivanov Andrej
Published: April 2019

Today the buildings of the 60-80th of the XX century do not satisfy to modern requirements for energy saving. The low value of the resistance to heat transfer leads overcooling of the wall surface in the cold period of the year and to overheating in the warm period. In addition, over the years of operation building envelopes subjected to numerous of climatic changes that were not envisaged in the design earlier. The lowering of microclimate parameters in the room negatively affects to the comfort and health of a person. As a result, the specific heat consumption for heating increases, the resistance to heat transfer decreases, and the thermal diffusivity increases. Therefore, a new method for calculating the actual value of the resistance to heat transfer is developed. The problem of providing sanitary and hygienic and thermophysical comfort conditions in the premises of the student hostel of the Volga State University of technology is also being solved. This occurs by controlling the temperature of the internal surface of the outer walls with a heating cable. Such a design will not only keep the difference between the wall surface temperature and the internal air temperature within the limits of the norm, but will also help to solve the problem of condensate precipitation by raising the temperature of the inner surface of the wall above the dew-point temperature. The developed technique takes into account the conditions of the heat transfer regime at a particular time, and also makes a correction to the final value of the design resistance. This makes the technique applicable for processing the results of field experiments and determining the actual resistance to heat transfer. Also results of field experimental researches of external walls of buildings are resulted and the scheme of laboratory installation is shown.
THE VALUE OF MAGNETIC RESONANCE IMAGING AS COMPARED TO LAPAROSCOPY FOR THE DETECTION OF ENDOMETRIOSIS
Authors: ZADE MODARES SHAHRZAD , MOTEVASSELIAN MAHTAB , NAEIJI ZAHRA , BAHRAMZADE SARA , AMIRNAZARI BEHNAZ , SANEI TAHERI MORTEZA
Published: April 2019

The objective of the study is to determine the value of MRI for detecting Endometriosis by considering the main determinants of diagnostic accuracy which are essential to minimize false positive and false negative diagnoses. The present study aims to assess the diagnostic value of MRI as a standard reference to detect endometriosis as compared to the laparoscopic findings. According to the opinion given by a panel of experts, forty consecutive patients with complaints of chronic pelvic pain, infertility, dysmenorrhea, dyspareunia, cyclic hematuria, pelvic pain between menstrual cycles and corresponding gastrointestinal symptoms, were referred to the Radiology department for further evaluation. The MRI examinations were performed with a 1.5- T unit. After MRI, the patients underwent laparoscopy within a maximum interval of 10 days as the reference standard. Data was analysis by SPSS. Sixteen patients underwent normal laparoscopy and normal MRI without any endometriotic lesions. In the other 16 patients, laparoscopy could identify 24 sites of endometriosis (20 endometriomas, 3 in posterior cul-desac, 1 in trigon of bladder). 20 out of these 24 sites (83.3%) were reported in their MRI. It is evident that the MRI had a sensitivity, specificity, PPV, NPV, and accuracy of 93.7%, 100%, 100%, 94.1%, and 96.8%, respectively for the diagnosis of Endometriosis. MRI with its high sensitivity and specificity can be considered as a high reproducible tool to explore Endometriosis.