bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Efficient Synthesis of Benzothieno[3,2‐d]imidazo[1,2‐a]pyrimidine‐2,5‐(1H, 3H)‐diones via a Tandem aza‐Wittig/Heterocumulene‐Mediated Annulation.
Authors: Xu Sheng‐Zhen , Wu Jing , Cao Min‐Hui , Ding Ming‐Wu
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Fungicidal Activity of 2‐Substituted‐3‐(4‐fluorophenyl)‐benzofuro[3,2‐d]pyrimidin‐4(3H)‐ones.
Authors: Hu Yang‐Gen , Xu Jing , Gao Hai‐Tao , Ma Zuan
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iodine Catalyzed One‐Pot Multicomponent Synthesis of a Library of Compounds Containing Tetrazolo[1,5‐a]pyrimidine Core.
Authors: Zeng Li‐Yan , Cai Chun
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Antioxidant and Antibacterial Activities of Novel N′‐Arylmethylidene‐2‐(3,4‐dimethyl‐5,5‐dioxidopyrazolo[4,3‐c] [1,2]benzothiazin‐2(4H)‐yl)acetohydrazides.
Authors: Ahmad Matloob , Siddiqui Hamid Latif , Zia‐ur‐Rehman Muhammad , Parvez Masood
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient One‐Pot Synthesis of Trisubstituted 1,3,5‐Triazines Through Intermediary Amidinothioureas.
Authors: Kaila Jitendra C. , Baraiya Arshi B. , Pandya Amit N. , Jalani Hitesh B. , Sudarsanam V. , Vasu Kamala K.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium‐Catalyzed Dehydrogenative Borylation of Cyclic Alkenes.
Authors: Kondoh Azusa , Jamison Timothy F.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pd‐Catalyzed Intramolecular Oxyalkynylation of Alkenes with Hypervalent Iodine.
Authors: Nicolai Stefano , Erard Stephane , Fernandez Gonzalez Davinia , Waser Jerome
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of a Storable Zinc Carbenoid Species and Its Application in Cyclopropanation, Chain Extension, and [2,3]‐Sigmatropic Rearrangement Reactions.
Authors: Voituriez Arnaud , Zimmer Lucie E. , Charette Andre B.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Click Chemistry Inspired Synthesis of Ferrocene Amino Acids and Other Derivatives.
Authors: Sudhir V. Sai , Kumar N. Y. Phani , Chandrasekaran S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of the First Representative (VIII) of Dicarbothiacyanine Dyes with Completely Fluorinated Polymethine Chain.
Authors: Yagupolskii Lev M. , Chernega Oksana I. , Kondratenko Nataliya V. , Chernega Alexander N. , Vlasenko Yurii G. , Nedelkov Ruslan V. , Yagupolskii Yurii L.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Two New Sesquiterpene Derivatives from the Tunisian Endemic Ferula tunetana Pom.
Authors: Jabrane Aymen , Ben Jannet Hichem , Mighri Zine , Mirjolet Jean‐Francois , Duchamp Olivier , Harzallah‐Skhiri Fethia , Lacaille‐Dubois Marie‐Aleth
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Integrating Enzymatic and Acid Catalysis to Convert Glucose into 5‐Hydroxymethylfurfural.
Authors: Huang Renliang , Qi Wei , Su Rongxin , He Zhimin
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Lignan and a New Sesquiterpene from Eurotia ceratoides (L.)
Authors: Siddiqui Bina Shaheen , Butabayeva Kalamkas Zhanarbekovna , Burasheva Gauhar Shahmanovna , Perwaiz Sobiya , Ali Syed Kashif , Bhatti Huma Aslam
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Macrocyclic BACE‐1 Inhibitors Acutely Reduce Aβ in Brain After Po Application.
Authors: Lercher Andreas , et al. et al.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Spiropiperidine‐Based Stearoyl‐CoA Desaturase‐1 Inhibitors: Identification of 1′‐{6‐[5‐(Pyridin‐3‐ylmethyl)‐1,3,4‐oxadiazol‐2‐yl] pyridazin‐3‐yl}‐5‐(trifluoromethyl)‐3,4‐dihydrospiro [chromene‐2,4′‐piperidine].
Authors: Uto Yoshikazu , et al. et al.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bulk Solar Grade Silicon: How Chemistry and Physics Play to Get a Benevolent Microstructured Material
Authors: Pizzini S.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Multiferroic Materials: The Attractive Approach of Metal—Organic Frameworks (MOFs)
Authors: Rogez Guillaume , Viart Nathalie , Drillon Marc
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Nucleophilic Phosphinidene Complexes: Access and Applicability
Authors: Aktas Halil , Slootweg J. Chris , Lammertsma Koop
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organoiron‐Mediated Dendrimer Syntheses with 1→3 Connectivity and Applications
Authors: Astruc Didier , Ruiz Jaime
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Naturally Occurring δ‐Hydroxy‐γ‐lactones: Muricatacins and Related Compounds
Authors: Murcia M. Carmen , Navarro Cristina , Moreno Ana , Csaky Aurelio G.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in the Design and Use of Immobilized N‐Heterocyclic Carbene Ligands for Transition‐Metal Catalysis
Authors: Cazin Catherine S. J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Pharmaceutical Synthesis
Authors: Sekhon Bhupinder Singh
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phloroglucinol Compounds of Natural Origin: Synthetic Aspects
Authors: Singh Inder Pal , Sidana Jasmeen , Bharate Sandip B. , Foley William J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Chemistry of Low Molecular Weight Black Tea Polyphenols
Authors: Drynan James Warren , Clifford Michael N. , Obuchowicz Jacek , Kuhnert Nikolai
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Charged‐Assisted Supramolecular Catalysis
Authors: Rix Diane , Lacour Jerome
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Cage‐Like Amino Alcohols. Synthesis, Reactions, and Application
Authors: Kas'yan L. I. , Pal'chikov V. A.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Oligonucleotide N3′→P5′ Phosphoramidates and Thio‐Phosphoramidates as Potential Therapeutic Agents
Authors: Gryaznov Sergei M.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthetic Nanotubes from Calixarenes
Authors: Rudkevich Dmitry M. , Organo Voltaire G.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rotaxanes as Ligands for Molecular Machines and Metal‐Organic Frameworks
Authors: Loeb Stephen J.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Supramolecular Macrocycle Synthesis by H‐Bonding Assembly
Authors: Ballester Pablo , de Mendoza Javier
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbohydrates as Chiral Auxiliaries
Authors: Kunz Horst
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Molecular Iodine Mediated Cyclization of Tethered Heteroatom‐Containing Alkenyl or Alkynyl Systems
Authors: Mphahlele Malose Jack
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: [1n]Paracyclophanes
Authors: Takemura Hiroyuki
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Ubiquitous Phosphine—Borane Complex
Authors: Laneman Scott A.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring Rearrangement Metathesis (RRM) in Alkaloid Synthesis
Authors: Holub Nicole , Blechert Siegfried
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Progress in the Asymmetric Hydrosilylation of Ketones and Imines
Authors: Arena Carmela G.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Applications of Microwave Irradiation to Medicinal Chemistry
Authors: Alcazar Jesus , Oehlrich Daniel
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave Chemistry Enabling the Synthesis of Biologically Relevant Amines
Authors: Spencer John
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Constituents of Plants from the Genus Viburnum
Authors: Wang Xiao‐Yu , Shi Hai‐Ming , Li Xiao‐Bo
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Biomimetic Ferric Hydroperoxo Porphyrin Intermediate
Authors: de Visser Sam P. , Valentine Joan Selverstone , Nam Wonwoo
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Carbon Nanomaterials in Biosensors: Should You Use Nanotubes or Graphene?
Authors: Yang Wenrong , Ratinac Kyle R. , Ringer Simon P. , Thordarson Pall , Gooding J. Justin , Braet Filip
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Peptide‐Based Methods for the Preparation of Nanostructured Inorganic Materials
Authors: Chen Chun‐Long , Rosi Nathaniel L.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Suppression of Hepatitis C Virus (HCV) Replication with Serine Palmitoyltransferase Inhibitor
Authors: Hirata Yuichi , Sudoh Masayuki , Kohara Michinori
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Viral Safety of Biologicals: Evaluation of Hepatitis C Virus (HCV) Nucleic Acid Amplification Test (NAT) Assay and Development of Concentration Method of HCV for Sensitive Detection by NAT
Authors: Uchida Eriko , Yamaguchi Teruhide
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Relativistic Pseudopotential Model for Superheavy Elements: Applications to Chemistry of Eka‐Hg and Eka‐Pb
Authors: Zaitsevskii A. V. , van Wuellen C. , Titov A. V.
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Quantum Mechanical Calculation of NMR Parameters in the Stereostructural Determination of Natural Products
Authors: Di Micco Simone , Chini Maria Giovanna , Riccio Raffaele , Bifulco Giuseppe
Published: May 2010

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Variations in labeling protocol influence incorporation, distribution and retention of iron oxide nanoparticles into human umbilical vein endothelial cells
Authors: van Tiel Sandra T. , Wielopolski Piotr A. , Houston Gavin C. , Krestin Gabriel P. , Bernsen Monique R.
Published: May 2010

Various studies have shown that various cell types can be labeled with iron oxide particles and visualized by magnetic resonance imaging (MRI). However, reported protocols for cell labeling show a large variation in terms of labeling dose and incubation time. It is therefore not clear how different labeling protocols may influence labeling efficiency. Systematic assessment of the effects of various labeling protocols on labeling efficiency of human umbilical vein endothelial cells (HUVEC) using two different types of iron oxide nanoparticles, i.e. super paramagnetic iron oxide particles (SPIOs) and microparticles of iron oxide (MPIOs), demonstrated that probe concentration, incubation time and particle characteristics all influence the efficiency of label incorporation, label distribution, label retention and cell behavior. For SPIO the optimal labeling protocol consisted of a dose of 12.5 µg iron/2 ml/9.5 cm2 and an incubation time of 24 h, resulting in an average iron load of 12.0 pg iron/per cell (uptake efficiency of 9.6%). At 4 h many SPIOs are seen sticking to the outside of the cell instead of being taken up by the cell. For MPIO optimal labeling was obtained with a dose of 50 µg iron/2 ml/9.5 cm2. Incubation time was of less importance since most of the particles were already incorporated within 4 h with a 100% labeling efficiency, resulting in an intracellular iron load of 626 pg/cell. MPIO were taken up more efficiently than SPIO and were also better tolerated. HUVEC could be exposed to and contain higher amounts of iron without causing significant cell death, even though MPIO had a much more pronounced effect on cell appearance. Using optimal labeling conditions as found for HUVEC on other cell lines, we observed that different cell types react differently to identical labeling conditions. Consequently, for each cell type separately an optimal protocol has to be established. Copyright © 2010 John Wiley & Sons, Ltd.
Primary systemic chemotherapy for inflammatory breast cancer
Authors: Sinclair Sarah , Swain Sandra M.
Published: May 2010

The advent of multimodality therapy for patients with inflammatory breast cancer (IBC), consisting of neoadjuvant chemotherapy, particularly taxanes, surgery, radiotherapy, and hormonal therapy, has improved survival. A pathologic complete response to neoadjuvant chemotherapy in locally advanced breast cancer and IBC improves outcomes, which suggests that obtaining a pathologic complete response to neoadjuvant chemotherapy has prognostic significance. The benefit of high‐dose chemotherapy has shown encouraging results; however, this approach needs to be prospectively evaluated and to date remains experimental. Vascular endothelial growth factor, a promoter of angiogenesis, is highly expressed in IBC, making the angiogenesis pathway an attractive therapeutic target. A better understanding of the complex biology of IBC is needed for the development of additional targeted agents to further improve outcomes for patients with this aggressive form of breast cancer. Cancer 2010;116(11 suppl):2821–8. © 2010 American Cancer Society.
Advances in imaging of inflammatory breast cancer
Authors: Yang Wei Tse
Published: May 2010

The key roles of imaging in inflammatory breast cancer using mammography, sonography, magnetic resonance imaging, and positron emission tomography/computed tomography to facilitate image‐guided biopsy for biomarker evaluation, delineate disease extent, diagnose distant metastases, and monitor response to therapy are described in this article. Cancer 2010;116(11 suppl):2755–7. © 2010 American Cancer Society.
Novel targeted therapies in inflammatory breast cancer
Authors: Cristofanilli Massimo
Published: May 2010

Inflammatory breast cancer (IBC) accounts for 1% to 5% of all breast cancer cases. Its aggressive biology is characterized by rapid disease progression and poor prognosis. To improve and standardize therapy for IBC, development of novel therapeutics to molecular targets of IBC is key. Trastuzumab treatment, an anti‐HER2 humanized monoclonal antibody, has been demonstrated to improve the 3‐year survival rate of patients with IBC (70.1% vs 53.3%; P = .0007). Another chemotherapeutic drug, lapatinib, a dual tyrosine inhibitor of epidermal growth factor (EGFR) and HER2 signaling, in combination with capecitabine demonstrated encouraging results, with a 51% decrease in disease progression. Further investigation is needed to confirm the efficacy of lapatinib. Cancer 2010;116(11 suppl):2837–9. © 2010 American Cancer Society.
Parallel implementations of the False Nearest Neighbors method for distributed memory architectures
Authors: Marín Carrión I. , Arias Antúnez E. , Artigao Castillo M. M. , Miralles Canals J. J.
Published: May 2010

The False Nearest Neighbors (FNN) method is particularly relevant in several fields of science and engineering (medicine, economics, oceanography, biological systems, etc.). In some of these applications, it is important to give results within a reasonable time scale; hence, the execution time of the FNN method has to be reduced. This paper describes two parallel implementations of the FNN method for distributed memory architectures. A ‘Single‐Program, Multiple Data’ (SPMD) paradigm is employed using a simple data decomposition approach where each processor runs the same program but acts on a different subset of the data. The computationally intensive part of the method lies mainly in the neighbor search and therefore this task is parallelized and executed using 2 to 64 processors. The accuracy and the performance of the two parallel approaches are then assessed and compared with the best sequential implementation of the FNN method, which appears in the TISEAN project. The results indicate that the two parallel approaches, when the method is run using 64 processors on a SGI Origin 3800, are between 40 and 80 times faster than the sequential one. The efficiency is between 65 and 125%. Copyright © 2010 John Wiley & Sons, Ltd.
Progressive neurogenesis defines lateralis somatotopy
Authors: Pujol‐Martí Jesús , Baudoin Jean‐Pierre , Faucherre Adèle , Kawakami Koichi , López‐Schier Hernán
Published: May 2010

Fishes and amphibians localize hydromechanical variations along their bodies using the lateral‐line sensory system. This is possible because the spatial distribution of neuromasts is represented in the hindbrain by a somatotopic organization of the lateralis afferent neurons' central projections. The mechanisms that establish lateralis somatotopy are not known. Using BAPTI and neuronal tracing in the zebrafish, we demonstrate growth anisotropy of the posterior lateralis ganglion. We characterized a new transgenic line for in vivo imaging to show that although peripheral growth‐cone structure adumbrates somatotopy, the order of neurogenesis represents a more accurate predictor of the position of a neuron's central axon along the somatotopic axis in the hindbrain. We conclude that progressive neurogenesis defines lateralis somatotopy. Developmental Dynamics 239:1919–1930, 2010. © 2010 Wiley‐Liss, Inc.
Single‐cell analysis of somatotopic map formation in the zebrafish lateral line system
Authors: Sato Akira , Koshida Sumito , Takeda Hiroyuki
Published: May 2010

The zebrafish lateral line is a simple sensory system comprising a small number of neurons in addition to their sensory organs, the neuromasts. We have adopted this system as a model for single‐cell level analyses of topographic map formation and examined when and how the lateral line topographic map is established. Single‐neuron labeling demonstrated that somatotopic organization of the ganglion emerges by 54 hr postfertilization, but also that this initial map is not as accurate as that observed at 6 days postfertilization. During this initial stage, individual neurons exhibit extensively diverse behavior and morphologies. We identified leader neurons, the axons of which are the first to reach the tail, and later‐appearing axons that contribute to the initial map. Our data suggest that lateral line neurons are heterogeneous from the beginning of lateral line development, and that some of them are intrinsically fate determined to contribute to the somatotopic map. Developmental Dynamics 239:2058–2065, 2010. © 2010 Wiley‐Liss, Inc.
The transcriptional activity of Neurog3 affects migration and differentiation of ectopic endocrine cells in chicken endoderm
Authors: Rosenberg Louise C. , Lafon Merete L. , Pedersen Jesper Karup , Yassin Hani , Jensen Jan Nygaard , Serup Palle , Hecksher‐Sørensen Jacob
Published: May 2010

Neurog3 is expressed transiently in pancreatic endocrine progenitors where it is responsible for activating a transcription factor cascade which eventually defines the mature endocrine cells. However, the mechanism by which Neurog3 regulates different aspects of the endocrine differentiation program is less clear. In this report we used in ovo electroporation to investigate how manipulation of Neurog3 protein activity affected migration, differentiation and fate determination. We found that changes in the onset of Neurog3 expression only had minor effect on differentiation. However increasing the transcriptional activity of Neurog3 by fusing it to VP16 or co‐electroporating with Ep300 caused the electroporated cells to migrate rather than differentiate. In contrast, reducing the transcriptional activity of Neurog3 by deleting parts of the activation domain, by fusing Neurog3 to the engrailed repressor domain, or co‐electroporating with Hdac1 greatly increased the proportion of glucagon expressing cells. Developmental Dynamics 239:1950–1966, 2010. © 2010 Wiley‐Liss, Inc.
Theoretical Study on Hetero‐Diels–Alder Reaction of Butadiene with Benzaldehyde Catalyzed by Chiral InIII Complexes
Authors: Cao Xiuli , Qin Song , Su Zhishan , Yang Huaqing , Hu Changwei , Feng Xiaoming
Published: May 2010

The mechanism of the hetero‐Diels–Alder reaction of butadiene with benzaldehyde catalyzed by chiral N,N′‐dioxide/In(OTf)3 complexes was studied theoretically by using density functional theory (DFT) and model system. The computational results indicate that the catalyzed reaction proceeded through a concerted mechanism via a highly zwitterionic transition state. The lowest energy barrier was 11.8 kJ mol–1, which is 63.0 kJ mol–1 lower than that of the uncatalyzed reaction. The results indicate that the endo approach is advantageous over the exo approach, because exo transitions states suffer from more steric hindrance than the endo transitions states as a result of interactions among the substrates, the trifluoromethanesulfonic group and the R4 groups of the ligand. The (S) configuration was observed predominantly over the (R) form, because there is no distinguishable repulsion between butadiene and the exo amino side or the endo amino side of the ligand. Besides, the interactions between the terminal hydrogen atoms of butadiene and the oxygen atoms of the trifluoromethanesulfonic group make the structure more stable. Thus, the experimental results were explained well by calculation of the chiral N,N′‐dioxide/In(OTf)3 complex catalyzed hetero‐Diels–Alder reaction at the molecular level.
Glucosinolate Chemistry: Synthesis of O‐Glycosylated Derivatives of Glucosinalbin
Authors: Gueyrard David , Iori Renato , Tatibouët Arnaud , Rollin Patrick
Published: May 2010

The synthesis of the major glucosinolate of Moringa oleifera and of other non‐natural O‐glycosylated derivatives of glucosinalbin is reported. The synthetic sequence applied, which involves the conversion of carbohydrate‐based nitrostyrenes into the key thiohydroximates, appears to be sufficiently versatile to synthesize a range of glucosinolatesbearing a glycosylated phenolic function. We synthesizedanalogues of the naturally occurring L‐rhamnoside 1 with a view to estimating the importance of this phenol‐protecting sugar moiety in modulating the biological activity of the parent glucosinolate and related breakdown products.
Convergent Synthesis and Biological Evaluation of Syringolin A and Derivatives as Eukaryotic 20S Proteasome Inhibitors
Authors: Clerc Jérôme , Schellenberg Barbara , Groll Michael , Bachmann André S. , Huber Robert , Dudler Robert , Kaiser Markus
Published: May 2010

A convergent synthesis of SylA was developed and consists of the synthesis of a fully functionalized macrocycle, which is subsequently coupled with a urea moiety. For cyclization, ring‐closing metathesis of a conformationally preorganized precursor was employed. The established synthetic route was then applied to the synthesis of SylA derivatives by using various peptidic side chains for decoration of the SylA macrocycle. The resulting collection of SylA analogues was tested for proteasome inhibition, revealing PEGylated SylA derivatives as the most potent proteasome inhibitors.
Spurious hypercalcitoninemia and heterophilic antibodies in patients with thyroid nodules
Authors: Giovanella Luca , Suriano Sergio
Published: May 2010

Background

The purpose of our study was to examine the prevalence of significant heterophilic antibody (HAb) interferences in serum calcitonin measurement in a large cohort of patients with thyroid nodules.

Methods

Enrolled in the study were 378 patients with thyroid nodules shown not to have medullary thyroid carcinoma (MTC) after extensive diagnostic workup. Serum calcitonin measurement was performed before and after incubating each serum sample in heterophilic‐blocking tubes (HBTs) and the differences were calculated. Samples showing an absolute percentage difference greater than 3 SD from the mean percentage difference were considered as affected by heterophilic antibody interference.

Results

Five of 378 patients (1.3%) with HAb interferences were identified, 4 with clinically relevant false‐positive calcitonin results.

Conclusion

A false‐positive calcitonin result due to HAb interference occurs more frequently than MTC (1.3% vs 0%) in our patient series. A serum pretreatment in HBTs should be considered when increased serum calcitonin levels are found in a patient with a thyroid nodule to prevent unwarranted investigations or therapies. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Frequency of bilateral cervical metastases in oropharyngeal squamous cell carcinoma: A retrospective analysis of 352 cases after bilateral neck dissection
Authors: Olzowy Bernhard , Tsalemchuk Yulia , Schotten Klaus‐Juergen , Reichel Oliver , Harréus Ulrich
Published: May 2010

Background

The decision whether to perform an elective neck dissection in patients with head and neck squamous cell carcinoma (HNSCC) and clinically negative lymph nodes (cN0) is made based on the probability of micrometastases in the neck for the given subsite and size of the primary. To date there is limited information about contralateral and bilateral cervical lymph node metastases of oropharyngeal carcinoma.

Methods

A retrospective chart review was performed of 352 patients with oropharyngeal SCC who received a bilateral neck dissection. The frequency of histologically unveiled bilateral neck metastases was determined.

Results

Carcinomas of the tonsillar fossa starting with a T2 classification and carcinomas of the soft palate, base of tongue, and pharyngeal wall at any stage showed a high frequency of bilateral metastases.

Conclusions

Bilateral neck dissection should be recommended for all but T1 and selected cases of T2 carcinomas of the tonsillar fossa. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Prognostic significance of p16 in locally advanced squamous cell carcinoma of the head and neck treated with concurrent cisplatin and radiotherapy
Authors: Lau Harold Y. , Brar Sony , Klimowicz Alexander C. , Petrillo Stephanie K. , Hao Desirée , Brockton Nigel T. , Kong Christina S. , Lees‐Miller Susan P. , Magliocco Anthony M.
Published: May 2010

Background

Human papillomavirus (HPV)–related squamous cell cancer of the head and neck (SCCHN) has emerged as a distinct clinical entity. The expression of p16 protein can be used as a surrogate for HPV status.

Methods

p16 immunohistochemistry (IHC) was assessed in archival paraffin‐embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation. HPV status was assessed by colorimetric in situ hybridization (CISH) and polymerase chain reaction (PCR).

Results

Compared with p16‐ and HPV‐negative patients, the p16‐ and HPV‐positive patients had improved overall survival, disease‐free survival, and locoregional recurrence rates.

Conclusions

p16 IHC may serve as a useful surrogate and prognostic marker for patients with HPV‐related SCCHN treated with cisplatin and radiation. © 2010 Wiley Periodicals, Inc. Head Neck, 2011
Therapeutic potential of adult bone marrow‐derived mesenchymal stem cells in diseases of the skeleton
Authors: Chanda Diptiman , Kumar Sanjay , Ponnazhagan Selvarangan
Published: May 2010

Mesenchymal stem cells (MSCs) are the most popular among the adult stem cells in tissue engineering and regenerative medicine. Since their discovery and functional characterization in the late 1960s and early 1970s, MSCs or MSC‐like cells have been obtained from various mesodermal and non‐mesodermal tissues, although majority of the therapeutic applications involved bone marrow‐derived MSCs. Based on its mesenchymal origin, it was predicted earlier that MSCs only can differentiate into mesengenic lineages like bone, cartilage, fat or muscle. However, varied isolation and cell culturing methods identified subsets of MSCs in the bone marrow which not only differentiated into mesenchymal lineages, but also into ectodermal and endodermal derivatives. Although, true pluripotent status is yet to be established, MSCs have been successfully used in bone and cartilage regeneration in osteoporotic fracture and arthritis, respectively, and in the repair of cardiac tissue following myocardial infarction. Immunosuppressive properties of MSCs extend utility of MSCs to reduce complications of graft versus host disease and rheumatoid arthritis. Homing of MSCs to sites of tissue injury, including tumor, is well established. In addition to their ability in tissue regeneration, MSCs can be genetically engineered ex vivo for delivery of therapeutic molecule(s) to the sites of injury or tumorigenesis as cell therapy vehicles. MSCs tend to lose surface receptors for trafficking and have been reported to develop sarcoma in long‐term culture. In this article, we reviewed the current status of MSCs with special emphasis to therapeutic application in bone‐related diseases. J. Cell. Biochem. 111: 249–257, 2010. © 2010 Wiley‐Liss, Inc.
Caveolin expression and activation in retroperitoneal and subcutaneous adipocytes: Influence of a high‐fat diet
Authors: Gómez‐Ruiz Ana , Milagro Fermín I. , Campión Javier , Martínez J. Alfredo , de Miguel Carlos
Published: May 2010

The effect of a high‐fat diet on the expression of the three main isoforms of caveolins in adipocytes isolated from rat retroperitoneal and subcutaneous white adipose tissue was investigated. Two distinct phases can be distinguished on a time‐dependent response in adipocytes from both locations. The early stage affects only to retroperitoneal adipocytes and implies caveolin‐1 activation and caveolin‐2 inactivation, together with increased expression of insulin signaling intermediaries. This initial response would be aimed to counterbalance the energy overload. Continued exposure to the high‐fat diet produces an increase in circulating glucose and insulin levels, inducing a late stage in which adipocytes from both locations are affected. This late stage is characterized by general increased caveolin‐1 and caveolin‐2 expression; while on the other hand, the insulin signaling intermediaries are downregulated, with the noticeable exception of GLUT‐4, whose expression remains high. Therefore, it seems that at this stage caveolins and GLUT‐4 are regulated independently of the insulin pathway, through a mechanism that could be mediated by inflammation and oxidative stress associated with obesity. Although this GLUT‐4 upregulation suggests a response against the raise in circulating glucose, this might not be the case, since the developing insulin resistance at this stage indicates a prediabetic state. We have also found that the high‐fat diet is able to induce the expression of muscle‐specific caveolin‐3 in retroperitoneal adipocytes since the initial phase. This observation is similar to what we reported previously in skeletal muscle (Gómez‐Ruiz et al., 2009, FEBS Lett 583:3259–3264), suggesting a similar regulatory mechanism for this isoform. J. Cell. Physiol. 225: 206–213, 2010. © 2010 Wiley‐Liss, Inc.
Soil‐carbon turnover under different crop management: Evaluation of RothC‐model predictions under Pannonian climate conditions
Authors: Rampazzo Todorovic Gorana , Stemmer Michael , Tatzber Michael , Katzlberger Christian , Spiegel Heide , Zehetner Franz , Gerzabek Martin H.
Published: May 2010

Despite the importance of soil organic matter (SOM), very few long‐term data concerning soil organic‐C dynamics are available for calibrating and evaluating C models. The long‐term 14C‐turnover field experiment, established in 1967 in Fuchsenbigl, Lower Austria, offers the unique opportunity to follow the fate of labeled C under different crop‐management systems (bare fallow, spring wheat, crop rotation) over a period of more than 35 y. Compared with the crop‐rotation and spring‐wheat treatments, the decline of total organic C was largest in the bare‐fallow treatments, because no significant C input has occurred since 1967. Nonetheless, the decline was not as fast as predicted with the original RothC‐26.3‐model decomposition rate constants. In this work, we therefore calibrated the Roth‐C‐26.3 model for the Pannonian climatic region based on the field‐experiment results. The main adjustment was in the decomposition rate constant for the humified soil C pool (HUM), which was set to 0.009 instead of 0.02 y–1 as determined in the original Rothamsted field trial. This resulted in a higher HUM pool in the calibrated model because of a longer turnover period (111 vs. 50 y). The modeled output based on the calibrated model fitted better to measured values than output obtained with the original Roth‐C‐26.3‐model parameters. Additionally, the original decomposition rate constant for resistant plant material (RPM) was changed from 0.3 to 0.6 y–1 to describe the decomposition of 14C‐labeled straw more accurately. Application of the calibrated model (modified HUM decomposition rate) to simulate removal of crop residues showed that this can entail a long‐term decline of SOM. However, these impacts are strongly dependent on the crop types and on environmental conditions at a given location.
Leaf and canopy optical characteristics as crop‐N‐status indicators for field nitrogen management in corn
Authors: Rambo Lisandro , Ma Bao‐Luo , Xiong Youcai , Regis Ferreira da Silvia Paulo
Published: May 2010

The primary constraint of predicting the economic optimum nitrogen rate (EONR) for corn (Zea mays L.) is the high variability of soil nitrogen (N) supply due to environments, soil types, manure, and cropping histories. Portable instruments have been developed to measure leaf and canopy optical characteristics for determining plant N status. The objectives of this field study were to: (1) evaluate leaf and canopy optical properties including transmittance, reflectance, and fluorescence as indicators of corn N status with soil types, developmental stages, and N‐application rates, (2) compare the efficiency of two commercial radiometers that are designed to measure canopy reflectance, and (3) assess the constraints of these crop‐based indicators as a possible guide for real‐time N sidedressing in corn. Field experiments with different levels of N, soil types, and corn hybrids were conducted at three sites in Ottawa, ON, Canada, in 2004 and 2005. Leaf chlorophyll concentrations (SPAD chlorophyll meter), chlorophyll fluorescence (OS‐30), leaf area, and canopy reflectance (NDVI measured by CropScan and GreenSeeker radiometers) were simultaneously measured at several growth stages, while grain yield was determined at harvest. Our results show that canopy reflectance (NDVI) displayed similar efficiency as an indicator of N status on both soil types and corn hybrids in the two consecutive years. The chlorophyll readings often differentiated N‐deficient from N‐sufficient plots and therefore were a promising indicator for predicting corn N requirements. The fluorometer device evaluated in this study was unable to characterize corn N status.