bluuebunny/crossref_metadata_2025 huggingface dataset:
Numerical Study of Flow Downstream a Step with a Cylinder Part 2: Effect of a Cylinder on the Flow over the Step
Authors: Abdollahpour Milad , Gualtieri Paola , Vetsch David F. , Gualtieri Carlo
Published: February 2023

In this study, divided into two parts, the effect on a two-dimensional backward-facing step flow (BFSF) of a cylinder placed downstream of the step was numerically investigated. While in Part 1, the numerical simulations carried out without the cylinder were validated using the available literature data, in Part 2 the effect of the cylinder was investigated. In the laminar regime, different Reynolds numbers were considered. In the turbulent regime, the effects on the flow structure of a cylinder placed at different horizontal and vertical locations downstream of the step were comparatively studied. When the cylinder was positioned below the step edge mid-plane, flow over the step was not altered by a cylinder. However, in other locations of a cylinder, the added cylinder modified the structure of flow, increasing the skin friction coefficient in the recirculation zone. Furthermore, the pressure coefficient of the bottom wall increased immediately downstream of the cylinder and farther downstream of the reattachment point and remained stable in the flow recovery process. Moreover, the presence of the step significantly influenced the dynamics of the vortex generation and shedding leading to an asymmetric wake distribution.
Treatment of Diabetes Nephropathy in Mice by Germinating Seeds of Euryale ferox through Improving Oxidative Stress
Authors: Wang Yani , Yuan Huaibo , Wang Yidi
Published: February 2023

Diabetes can cause severe kidney disease. Euryale ferox seeds (Gordon Euryale) have known antioxidant, hypoglycemic, and renal protection effects. Methanol extracts of Gordon Euryale were produced from ungerminated and germinated seeds. The effect of germination on polyphenol and flavonoid content was investigated by Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Three doses of ungerminated seed extract (EKE) and germinated seed extract (GEKE) were administered to diabetic mice by gavage to explore the treatment-dependent improvement of oxidative stress, metabolic disorder, and kidney disease. Seed germination led to a 1.7 times increase in total phenol content in the extract, and the flavonoid content was increased by 1.9 times. Germination greatly increased the contents of 29 polyphenols and 1 terpenoid. At the same dose, GEKE more strongly improved hyperglycemia, abnormal lipid metabolism, and renal tissue lesions (as confirmed by histology) in the diabetic mice than EKE did. In diabetic mice receiving treatment, kidney microalbunminuria (ALB), blood urea nitrogen (BUN), serum creatinine (Scr), malondialdehyde (MDA), and glutathione (GSH) were all decreased, while activity of catalase (CAT), superoxide dismutase (SOD), and serum total antioxidant capacity (T-AOC) were increased. Both EKE and GEKE can improve diabetes and kidney disease by improving hyperglycemia, oxidative stress, and kidney physiological indicators and regulating the Keap1/Nrf2/HO-1 and AMPK/mTOR pathways. However, in both pathways, GEKE is more effective. The purpose of this study was to explore the effects of GEKE and EKE treatment on antioxidant defense and metabolic capacity of diabetic animals. Germination provides a suitable strategy to improve the medicinal value of these natural plant-based products.
A Physical Phenomenon for the Fractional Nonlinear Mixed Integro-Differential Equation Using a General Discontinuous Kernel
Authors: Alhazmi Sharifah E. , Abdou Mohamed A.
Published: February 2023

In this study, a fractional nonlinear mixed integro-differential equation (Fr-NMIDE) is presented and has a general discontinuous kernel based on position and time space. Conditions of the existence and uniqueness of the solution is provided through the principal form of the integral equation, based on the Banach fixed point theorem. After applying the properties of a fractional integral, the Fr-NMIDE conformed to the Volterra–Hammerstein integral equation (V-HIE) of the second kind, with a general discontinuous kernel in position with the Hammerstein integral term and a continuous kernel in time to the Volterra term. Then, using a technique of the separating method, we obtained HIE, where its physical coefficients were variable in time. The Toeplitz matrix method (TMM) and its schemes were used to obtain a nonlinear algebraic system by studying the convergence of the system. The Maple 18 program was implemented to present the numerical results, along with corresponding errors.
Weak Solution for a Fractional Langevin Inclusion with the Katugampola–Caputo Fractional Derivative
Authors: Almaghamsi Lamya
Published: February 2023

In this work, we examine the existence of weak solution for a class of boundary value problems involving fractional Langevin inclusion with the Katugampola–Caputo fractional derivative under specified conditions contain the Pettis integrability assumption. The Mönch fixed point theorem is used with the weak noncompactness measure approach to investigate the existence results. In order to illustrate our results, we present an example.
Third-Order Differential Subordination for Meromorphic Functions Associated with Generalized Mittag-Leffler Function
Authors: Attiya Adel A. , Seoudy Tamer M. , Albaid Abdelhamid
Published: February 2023

Using the results of third-order differential subordination, we introduce certain families of admissible functions and discuss some applications of third-order differential subordination for meromorphic functions associated with a linear operator containing a generalized Mittag-Leffler function.
Noise Spectral of GML Noise and GSR Behaviors for FGLE with Random Mass and Random Frequency
Authors: Qiu Lini , He Guitian , Peng Yun , Cheng Hui , Tang Yujie
Published: February 2023

Due to the interest of anomalous diffusion phenomena and their application, our work has widely studied a fractional-order generalized Langevin Equation (FGLE) with a generalized Mittag–Leffler (GML) noise. Significantly, the spectral of GML noise involving three parameters is well addressed. Furthermore, the spectral amplification (SPA) of an FGLE has also been investigated. The generalized stochastic resonance (GSR) phenomenon for FGLE only influenced by GML noise has been found. Furthermore, material GSR for FGLE influenced by two types of noise has been studied. Moreover, it is found that the GSR behaviors of the FGLE could also be induced by the fractional orders of the FGLE.
Stiffness-Modulation of Collagen Gels by Genipin-Crosslinking for Cell Culture
Authors: Ishihara Seiichiro , Kurosawa Haruna , Haga Hisashi
Published: February 2023

The stiffness of extracellular matrices (ECMs) is critical for cellular functions. Therefore, modulating the stiffness of ECMs in vitro is necessary to investigate the role of stiffness in cellular phenomena. Collagen gels are widely used for cell culture matrices in vitro. However, modulation of the stiffness in collagen gels for cell culture is challenging owing to the limited knowledge of the method to increase the stiffness while maintaining low cytotoxicity. Here, we established a novel method to modulate collagen gel stiffness from 0.0292 to 12.5 kPa with low cytotoxicity. We prepared collagens with genipin, a low-cytotoxic crosslinker of amines, at different concentrations and successfully modulated the stiffness of the gels. In addition, on 10 mM genipin-mixed collagen gels (approximately 12.5 kPa), H1299 human lung cancer cells showed spreading morphology and nuclear localization of yes-associated protein (YAP), typical phenomena of cells on stiff ECMs. Mouse mesenchymal stromal cells on 10 mM genipin-mixed collagen gels differentiated to vascular smooth muscle cells. On the other hand, the cells on 0 mM genipin-mixed collagen gels (approximately 0.0292 kPa) differentiated to visceral smooth muscle cells. Our new method provides a novel way to prepare stiffness-modulated collagen gels with low cytotoxicity in cell culture.
Protocol for a Randomized Crossover Trial to Evaluate the Effect of Soft Brace and Rigid Orthosis on Performance and Readiness to Return to Sport Six Months Post-ACL-Reconstruction
Authors: Jahnke Sonja , Cruysen Caren , Prill Robert , Kittmann Fabian , Pflug Nicola , Albert Justin Amadeus , de Camargo Tibor , Arnrich Bert , Królikowska Aleksandra , Kołcz Anna , Reichert Paweł , Oleksy Łukasz , Michel Sven , Kopf Sebastian , Wagner Michael , Scheffler Sven , Becker Roland
Published: February 2023

A randomized crossover trial was designed to investigate the influence of muscle activation and strength on functional stability/control of the knee joint, to determine whether bilateral imbalances still occur six months after successful anterior cruciate ligament reconstruction (ACLR), and to analyze whether the use of orthotic devices changes the activity onset of these muscles. Furthermore, conclusions on the feedforward and feedback mechanisms are highlighted. Therefore, twenty-eight patients will take part in a modified Back in Action (BIA) test battery at an average of six months after a primary unilateral ACLR, which used an autologous ipsilateral semitendinosus tendon graft. This includes double-leg and single-leg stability tests, double-leg and single-leg countermovement jumps, double-leg and single-leg drop jumps, a speedy jump test, and a quick feet test. During the tests, gluteus medius and semitendinosus muscle activity are analyzed using surface electromyography (sEMG). Motion analysis is conducted using Microsoft Azure DK and 3D force plates. The tests are performed while wearing knee rigid orthosis, soft brace, and with no aid, in random order. Additionally, the range of hip and knee motion and hip abductor muscle strength under isometric conditions are measured. Furthermore, patient-rated outcomes will be assessed.
Mobilizing the World Café Method for Adequate Development of Non-Technical Skills of Midwives in Morocco: A Pilot Experiment
Authors: Ghafili Asmaa , Azzouzi Widad , Hamdoune Meryem , Gantare Abdellah , Lobet-Maris Claire , Gourdin Maximilien
Published: February 2023

This article explores the development of the most critical soft skills in midwifery through the use of a participatory method called the World Café in the context of continuing education at the Formation and Simulation Center (FORSim) in Settat, Morocco. Non-technical skills include a set of metacognitive abilities that complement technical skills to ensure the safe execution of technical activities and the parturient’s satisfaction. In order to develop these midwifery skills through the World Café method, we invited nine midwives from two maternity units in the Casablanca-Settat region, with whom we elaborated our psychological, organizational, cognitive, and interactional (POCI) model. The study took place over a full day, structured into three distinct steps: a self-assessment of the level of mastery of the eight soft skills in the POCI model, four cycles of the World Café and, finally, a discussion of and feedback about the method. The use of the World Café method allowed for a dialogue on the possibilities of managing and addressing issues related to non-technical skills among midwives from various hospital settings. Based on the results, we found that the participants enjoyed the non-stressful atmosphere of the World Café and were very productive. The assessments and feedback from the midwives participating in this study suggest that managers can adopt the World Café approach to develop non-technical skills and enhance midwives’ interactions and soft skills as part of their continuing education.
The Importance of the International Community in Protecting the Right to Abortion: The Cases of Malta and of the US Supreme Court
Authors: Cioffi Andrea , Cecannecchia Camilla , Cipolloni Luigi , Santurro Alessandro , Cioffi Fernanda
Published: February 2023

According to the World Health Organization (WHO), abortion is often necessary and is not a criminalizable medical act. Unfortunately, despite the global trend in recent years tending towards liberalization of abortion as a fundamental right of women in certain circumstances, it is still not guaranteed in all countries of the world in the same way. Moreover, the abortion debate is often characterized by unscientific opinions based on political and/or religious ideologies. Recently, a European episode has rekindled the debate on abortion: in Malta, a tourist was unable to have an abortion, with consequent risks, even serious ones, on her health. In addition, even in the United States a Supreme Court ruling created a considerable stir: the Roe v. Wade (1973) ruling that had legalized abortion at the federal level was revoked. After the ruling of the Supreme Court, each state of the USA can decide for itself whether and how to legalize abortion. These recent international developments are particularly worrying and make even more evident the need for abortion to be protected at an international level as an inalienable and fundamental human right, and therefore not to be limited.
Do Tapping and Massaging during Tourniquet Application Promote Dilation of Forearm Cutaneous Veins? A Pilot Quasi-Experimental Study
Authors: Yasuda Kae , Okada Kazunori , Sugimura Naotaka , Yano Rika
Published: February 2023

Successful insertion of a peripheral intravenous catheterization requires that veins be sufficiently dilated. This study aimed to clarify the venous dilation effect of including tapping or massaging to the application of a tourniquet at the cutaneous veins of healthy adults’ forearms. This was a quasi-experimental study of 30 healthy adult volunteers. Each participant underwent all three venous dilation procedures, which included the tourniquet application (Control condition), the tourniquet application and tapping the participant’s forearm (Tapping condition), as well as the tourniquet application combined with massaging the participant’s forearm (Massage condition). To clarify the venous dilation effects, venous indices were measured, namely the venous diameter (mm), depth (mm), and palpation score. After applying all venous dilation procedures, the venous diameter and palpation score significantly increased. However, no significant difference was observed between the control condition and each intervention condition. The depth in the control and tapping conditions decreased significantly in contrast to the Massage condition. Moreover, a subgroup (nine participants with a venous diameter less than 3 mm after the control condition) had similar results. This study found that additional tapping or massaging after tourniquet application could be less effective in promoting dilation in the forearm veins of healthy adults. Future studies should examine the efficacy and effectiveness of venous dilation in a wide target population while considering intervention methods.
Upholding Quality and Patient Safety during COVID-19 Pandemic—A Jordanian Case Study
Authors: Dahmash Eman Zmaily , Madi Thaira , Hassan Samar Khaled , Oroud Yazan , Shatat Ahmad , Jalabneh Rawan , Rashideh Hafez Abu , Aljayyousi Aws , Iyire Affiong
Published: February 2023

Background: The advent of the COVID-19 pandemic caused a rapid increase in demand for healthcare services over a prolonged period, and the hospital emergency preparedness system has been essential. Therefore, this study aimed to explore Jordanian hospitals’ response to emergency situations and examine the underlying role and effect of accreditation programs as a “Quality and Patient Safety” tool to deal with emergency situations during the pandemic. Methods: An online survey for a cross-sectional study was conducted in Jordan between 1 March and 30 May 2022, to examine the opinions of hospitals’ top, senior, and middle managers using a validated questionnaire. Results: A total of 200 healthcare providers from 30 hospitals participated in the study. From the areas within accreditation standards that were investigated, capacity building on emergency preparedness and communication abilities received the least scores (2.46 and 2.48, respectively). Additionally, hospitals with mature quality and patient safety culture (>3 accreditation cycles) demonstrated a statistically significant difference in score in two domains–emergency preparedness (p = 0.027) and infection prevention and control (p = 0.024). Conclusions: During outbreaks, hospitals that are required to comply with accreditation standards that address all emergency preparedness aspects will fare better in quality performance.
Influence of the Culture System and Harvest Time on the Specialized Metabolite Composition of Rocket Salad (Eruca sativa) Leaves
Authors: Buitrago-Villanueva Ivon , Barbosa-Cornelio Ricardo , Coy-Barrera Ericsson
Published: February 2023

Eruca sativa is a leafy vegetable widely consumed fresh in salads and recognized for the presence of bioactive compounds, such as glucosinolates (GLS) and flavonols. This plant is traditionally cultivated in soils but adapts well to soilless cultures, such as hydroponics and aquaponics. However, despite the good results in the literature on E. sativa cultivation in soilless systems, the influence of the culture systems and harvest time on the specialized metabolite-based chemical composition of E. sativa leaves is not entirely understood. Based on the above, this study aimed to evaluate the specialized metabolite composition of three different cultivation types, i.e., using soil (SCS), nutrient film technique (NFT)-based hydroponic (HCS), and aquaponic (ACS) culture systems, along three growing cycles, and collected at two commercial harvest times, i.e., 21 days after transplanting (DAT) to get early plant material, namely “baby leaf”, and 42 DAT as the traditional harvest time. The chemical composition was obtained by liquid chromatography coupled with mass spectrometry (LC-MS), and multivariate statistics supported the analysis of the whole dataset. The SCS was characterized to promote an important accumulation of two antioxidant flavonols, i.e., (kaempferol and isorhamnetin diglucopyranosides) in young leaves (21 DAT). The hydroponically-grown plants exhibited a smaller number of various compounds. The ACS-cultivated leaves accumulated indole-containing glucosinolates and a marker associated with harvest time, spirobrassinin, a cruciferous oxindoline phytoalexin. These findings constitute the first report of those compounds relevantly accumulated by the effect of soilless cultures and a starting point for further studies related to the metabolite regulation of E. sativa under hydroponics and aquaponics.
The Impact of Urban Land-Use Regimes on the Stream Vegetation and Quality of a Mediterranean City
Authors: Theodosiou Georgios , Panajiotidis Sampson
Published: February 2023

Urban streams are ecosystems of great ecological and hydrological importance for human environments. However, they face pressure on biodiversity, hydromorphology, and water quality. In this study, an urban riparian system of a Mediterranean city (Thessaloniki, Greece) which interacts with several land-use classes, namely forests, pastures, cultivations, industrial-commercial infrastructure, and light and dense urban fabric, is assessed. The analyzed data were collected by implementing mainly QBR and ancillary RMP protocols on 37 plots of the Dendropotamos stream. The QBR protocol provided an assessment of total riparian vegetation cover, cover structure and quality, as well as channel alterations. The RMP protocol was used to enhance the quantitative assessment of dominant tree and shrub cover. Parts of Dendropotamos surrounded by agricultural (median QBR score: 27.5), industrial (50), and dense residential areas (27.5) suffer, in general, from low riparian vegetation cover, bad vegetation structure and quality, the continuous presence of alien/introduced species, and channel alterations. A variety of riparian habitat conditions characterize the sparse residential areas (60) where cover structure and quality of vegetation is improved. The reduction in grazing pressure has improved the riparian habitat in the greatest part of Dendropotamos that is surrounded by semi-natural pastures (65). Within forested areas (85), the stream conditions are considered quasi-natural. All previous land uses are differentiated in terms of the dominant trees found in the vegetation of Dendropotamos: Platanus orientalis in forested areas, alien Ailanthus altissima mainly in residential and industrial areas, and native shrubs, e.g., Quercus coccifera and Pyrus spinosa, in pastures. The QBR protocol could be a valuable tool in urban environment planning to help identify areas with potential for restoration, such as those with moderate residential pressure.
Image Haze Removal Method Based on Histogram Gradient Feature Guidance
Authors: Huang Shiqi , Zhang Yucheng , Zhang Ouya
Published: February 2023

Optical remote sensing images obtained in haze weather not only have poor quality, but also have the characteristics of gray color, blurred details and low contrast, which seriously affect their visual effect and applications. Therefore, improving the image clarity, reducing the impact of haze and obtaining more valuable information have become the important aims of remote sensing image preprocessing. Based on the characteristics of haze images, combined with the earlier dark channel method and guided filtering theory, this paper proposed a new image haze removal method based on histogram gradient feature guidance (HGFG). In this method, the multidirectional gradient features are obtained, the atmospheric transmittance map is modified using the principle of guided filtering, and the adaptive regularization parameters are designed to achieve the image haze removal. Different types of image data were used to verify the experiment. The experimental result images have high definition and contrast, and maintain significant details and color fidelity. This shows that the new method has a strong ability to remove haze, abundant detail information, wide adaptability and high application value.
Combined Effect of Climate and Anthropopressure on River Water Quality
Authors: Wieczorek Kinga , Turek Anna , Wolf Wojciech M.
Published: February 2023

This study was a continuation of our investigation of the spatio-temporal variability of the Bzura River’s water chemistry. Our research is of particular importance in the context of the recent ecological disaster on the Oder River and concerns the international problem of surface water contamination. The study area was a 120 km section of the Bzura River. We tested more measurement points and with a higher sampling frequency than those used in the national monitoring of river water quality. During two hydrological years, 360 water samples were collected. The selected parameters: electrical conductivity, temperature, dissolved oxygen, dissolved organic carbon, nitrates, phosphates, bicarbonates, chlorides, sodium, potassium, calcium, and magnesium were determined. Numerous results exceeded the Polish threshold limits. Spatio-temporal variability and water quality were assessed using principal component analysis (PCA), cluster analysis (CA), and water quality index (WQI) approaches. Many point sources of pollution related to urbanization, agriculture, and industry were detected. Moreover, due to the changing climatic conditions, a significant difference between temporal variability in both years was observed. Our results indicated that it is necessary to increase the number of measurement stations for surface water monitoring; it will allow for a faster detection of the threat.
Gender Differences in Determinants of the Components of the Frailty Phenotype among Older Adults in India: Findings from LASI Wave-1
Authors: Das Sayani , Prasad Jitender
Published: February 2023

This study examines the gender-specific determinants of the components of frailty in a community-dwelling setting in India. Using data from the Longitudinal Ageing Study in India (LASI) Wave-1, this study employed 30,978 (14,885 male and 16,093 female) older adults (aged 60+) to fulfil the study objective. The modified Fried frailty phenotype criteria defines frailty by the five components: exhaustion, weak grip strength, slow walking speed, unintentional weight loss, and low physical activity. The result showed grip strength (79.1%) as the most discriminant component among males, and physical activity (81.6%) as the most discriminant component among females. The results also indicated that grip strength (male: 98.0%, female: 93.5%) and physical activity (male: 94.8%, female: 96.9%) showed a sensitivity of more than 90%, which appears to be a good indicator of frailty. Combining this dual marker increased the accuracy to 99.97% among male and 99.98% among female samples. The findings suggested adding grip strength and physical activity as a proxy measure of frailty, which can increase the precision of screening without a large additional investment of time, training, or cost.
Response of Ecosystem Services to Land Use Change in Madagascar Island, Africa: A Multi-Scale Perspective
Authors: Tiandraza Flaubert , Qu Shijin , Hu Shougeng , Mkono Christopher N. , Tikhomirova Anna , Randrialahamady Solo Nirina
Published: February 2023

“Land Use and Land Cover Change (LULCC)” is increasingly being affected by ecosystem services value. LULCC patterns have been subjected to significant changes over time, primarily due to an ever-increasing population. It is rare to attempt to analyze the influence of such changes on a large variety of ecosystem benefits in Madagascar island. The economic value of ecosystem services in Madagascar island is evaluated throughout the period from 2000 to 2019. The expansion of the human population affects the changing value of ecosystem services directly. The PROBA-V SR time series 300 m spatial resolution cover of land datasets from the “Climate Change Initiative of the European Space Agency (ESA)” were used to measure the values of ecosystem activities and the changes in those values caused by land use. A value transfer method was used to evaluate the value of ecosystem services to land use changes on Madagascar island. The findings show that from 2000 to 2019, at the annual rate of 2.17 percent, Madagascar island’s ecosystem service value (ESV) grew to 6.99 billion US dollars. The components that greatly contributed to the total change of ESV were waste treatment, genetic resources, food production, and habitat/refugia. These components in 2000 contributed 21.27%, 20.20%, 17.38%, and 13.80% of the total ESV, and 22.55%, 19.76%, 17.29%, and 13.78% of the total ESV in 2019, respectively. Furthermore, it was found that there was a great change in LULCC. From 2000 to 2019, bare land, built-up land, cultivated land, savannah, and wetland increased while other LULCC types decreased. The sensitivity coefficient ranged from 0.649 to 1.000, <1, with forestland registering the highest values. Wetland is in the second position for the most important land cover category in Madagascar, considering the total value of the ecosystem. The value of ecosystem benefits per unit of the land area was higher on cultivated land, despite the relatively low fraction of cultivated land area across these eras. The sensitivity indices of seven land types from 2000 to 2019 were mapped to understand better the geographical distribution patterns of ESV’s “equivalent value coefficient” (VC) across various land uses. It is suggested that the ESV should be included in Madagascar’s government land-use plan to manage it effectively and efficiently with fewer negative effects on the ecosystem.
Prevention of Secondary Injury after Anterior Cruciate Ligament Reconstruction: Relationship between Pelvic-Drop and Dynamic Knee Valgus
Authors: D’Onofrio Rosario , Alashram Anas Radi , Annino Giuseppe , Masucci Matteo , Romagnoli Cristian , Padua Elvira , Manzi Vincenzo
Published: February 2023

(1) Background: Optimal neuromuscular, Lumbo-Pelvic-Hip Complex, and lower extremity control are associated with decreased risk factors for secondary anterior cruciate ligament (ACL) injury. This study aimed to analyze any asymmetries and malalignments in the Lumbo-Pelvic-Hip Complex and the lower limbs at 6 months after ACL reconstruction (ACLR). (2) Methods: We conducted an exploratory retrospective observational single-center study in patients during the outpatient postoperative rehabilitation program at ICOT (Latina, Italy). From January 2014 to June 2020, 181 patients were recruited, but only 100 patients (86 male 28 ± 0.6 years, 178 ± 0.5 height; 14 female 24 ± 2.0 years, 178 ± 3.0 height) were eligible for the inclusion criteria and studied 6 months after ACL reconstruction surgery. (3) Statistical analysis: Student’s t-tests and Pearson’s product-moment correlation coefficient were used to determine significant differences between affected and non-affected limbs and variables’ association. (4) Results: The study shows a decrease in neuromuscular control of the Lumbo-Pelvic-Hip Complex and dynamic adaptive valgus of the knee at 6 months after ACLR (mean difference between pathological and healthy limb of dynamic adaptive valgus was −10.11 ± 8.19° 95% CI −14.84 to −9.34; mean value was 16.3 ± 6.8° 95% CI 14.04 to 18.55 for healthy limb and 4.2 ± 3.1° 95% CI 3.15 to 5.21 for pathological limb, p < 0.0001). The results also showed a relationship between dynamic adaptive valgus and contralateral pelvic drop (r = 0.78, 95% CI 0.62 to 0.88, magnitude of correlation very large). (5) Conclusions: The analysis showed an associative correlation between decreased postural control of the pelvic girdle and dynamic adaptive valgus of the knee in 38% of patients; this study highlights the usefulness of the Single-Leg Squat Test (SLST) as a clinical/functional assessment to evaluate the rehabilitation process and as a preventive tool to reduce the risk of second ACL injuries during the return to sport.
Mechanisms of Transmission and Processing of Pain: A Narrative Review
Authors: Di Maio Girolamo , Villano Ines , Ilardi Ciro Rosario , Messina Antonietta , Monda Vincenzo , Iodice Ashlei Clara , Porro Chiara , Panaro Maria Antonietta , Chieffi Sergio , Messina Giovanni , Monda Marcellino , La Marra Marco
Published: February 2023

Knowledge about the mechanisms of transmission and the processing of nociceptive information, both in healthy and pathological states, has greatly expanded in recent years. This rapid progress is due to a multidisciplinary approach involving the simultaneous use of different branches of study, such as systems neurobiology, behavioral analysis, genetics, and cell and molecular techniques. This narrative review aims to clarify the mechanisms of transmission and the processing of pain while also taking into account the characteristics and properties of nociceptors and how the immune system influences pain perception. Moreover, several important aspects of this crucial theme of human life will be discussed. Nociceptor neurons and the immune system play a key role in pain and inflammation. The interactions between the immune system and nociceptors occur within peripheral sites of injury and the central nervous system. The modulation of nociceptor activity or chemical mediators may provide promising novel approaches to the treatment of pain and chronic inflammatory disease. The sensory nervous system is fundamental in the modulation of the host’s protective response, and understanding its interactions is pivotal in the process of revealing new strategies for the treatment of pain.
Do We Need Public Green Spaces Accessibility Standards for the Sustainable Development of Urban Settlements? The Evidence from Wrocław, Poland
Authors: Rubaszek Justyna , Gubański Janusz , Podolska Anna
Published: February 2023

Public green spaces (PGSs) have a positive impact on the health and wellbeing of urban residents. However, their accessibility can be limited due to high urbanisation pressures and inadequate or insufficient regulatory provisions. This problem has been recognised for Central European cities, of which Wrocław is an example, where the provision of PGS accessibility has not received major attention in recent decades, and the planning system has been in constant transformation since the transition from a centrally planned to a free-market economy. This study therefore aimed to examine the distribution and accessibility of PGSs in the expanding area of Wrocław today and upon implementation of the plans under the proposed standards. These analyses were performed using the QGIS application, network analysis, and the ISO-Area as polygon algorithm. The findings revealed a conspicuous lack of available PGSs, which includes areas above 2 ha, such as district and neighbourhood parks. New PGSs are now being planned, but even so, part of the residential areas will remain outside their catchment zone. The results obtained provide strong evidence that it is essential that standards should be a tool implemented in urban planning, and that the adopted procedure can be transferred to other cities.
Experiences with Family Planning amongst Persons with Mental Health Problems: A Nationwide Patient Survey
Authors: Schonewille Noralie N. , van den Eijnden Monique J. M. , Jonkman Nini H. , van Kempen Anne A. M. W. , van Pampus Maria G. , Goedhart Francisca G. , van den Heuvel Odile A. , Broekman Birit F. P.
Published: February 2023

High rates of unintended pregnancies in patients with mental health problems reflect the unmet need for tailored family planning. This study aims to explore aspects of family planning that are especially challenging for patients experiencing health problems by obtaining the perspective of (former) patients and those with close relationships with the (former) patients. In August 2021, members of a Dutch national mental health panel, consisting of (former) patients and close ones, were invited to respond to a 34-question online survey that included questions on four domains: reproductive history, decision making, parenting, and sexuality. This study has revealed the severe and adverse impact of mental health problems across all of the four domains of reproductive health and family planning, which the questions specifically targeted. Based on these results, we recommend discussing family planning with all patients experiencing or at risk for mental health problems and their partners. These discussions should address a desire to have children, (involuntary) childlessness, uncertainties about parenting and sexuality, while remaining considerate of experienced taboos.
The Dermatologic Care Needs of a Rural Community in South Florida
Authors: Asbeck Sara M. , Imo Brenda U. , Okobi Okelue E. , Dorcé-Medard Jennifer
Published: February 2023

For patients in rural areas, primary care is often their only access to healthcare services, and skin concerns are among the most common diseases seen in these settings. This study aims to investigate the most common skin conditions, management trends and patterns of referral to dermatology in a rural and underserved community in South Florida. A retrospective chart review was conducted using medical records from the C.L. Brumback Primary Care Clinic in Belle Glade, FL. The most common skin conditions were fungal infections, unspecified dermatitis, pruritus, skin cancer concern, alopecia, and autoimmune skin disorders. The most frequent management strategy was medication prescription followed by specialist referral. Of the 21 percent of patients referred to a specialist, 55 percent of these were to dermatology. The most common diagnoses referred to dermatology were atopic dermatitis and alopecia. Only 20 percent of these patients reported attending their follow-up appointment, and the average distance to referral was 21 miles. Belle Glade is unique in its need for and access to dermatologic care. The lack of access to specialists in rural communities is a public health issue that more studies and outreach initiatives should address.
The Effects of Heavy Metal Pollution on Collembola in Urban Soils and Associated Recovery Using Biochar Remediation: A Review
Authors: Kayiranga Alexis , Li Zhu , Isabwe Alain , Ke Xin , Simbi Claudien Habimana , Ifon Binessi Edouard , Yao Haifeng , Wang Bin , Sun Xin
Published: February 2023

Heavy metal pollution in urban soil continues to be a global issue that poses a serious hazard to invertebrates and human lives through oral ingestion and inhalation of soil particles. Though the toxicity of several heavy metals on invertebrates like Collembola has been studied, lead (Pb) and cadmium (Cd) have been extensively studied due to their high toxicity to collembolans. As a ubiquitous soil organism all over the world, collembolans have been used as a model species to study the effects of heavy metals on invertebrate communities. To reduce the effects of heavy metals on ecosystem functions, biotic and abiotic measures have been used for heavy metal remediation; biochar seems to be the most effective approach that not only increases the physical absorption of heavy metals but also indirectly benefits soil organisms. In this study, we briefly reviewed the application of biochar in Pb and Cd polluted soil and showed its potential in soil remediation. Furthermore, we outlined the potentially toxic effects of Pb- and Cd-polluted urban soil on the collembolan species. We searched peer-reviewed publications that investigated: (1) the level of Pb and Cd contamination on urban soil in different cities around the world; and (2) the different sources of Pb and Cd as well as factors influencing their toxicity to collembolan communities. The obtained information offers new perspectives on the interactions and effects between collembolans, Pb, and Cd, and their remediation in urban soils.
Changes in Physical Activity Associated with Mental Health in People with Type 1 Diabetes during the COVID-19 Pandemic
Authors: Uliana Gabriela Correia , Gomes Daniela Lopes , Galvão Olavo Faria , Paracampo Carla Cristina Paiva
Published: February 2023

The social isolation carried out during the COVID-19 pandemic contributed to physical inactivity and impacted people’s mental health, with physical activity being an important pillar in the treatment of Type 1 Diabetes Mellitus (T1DM). Thus, this study aims to verify whether there is an association between the perception of mental health and the practice of physical activity in individuals with T1DM during social isolation in the COVID-19 pandemic in Brazil. This was a cross-sectional study conducted in July 2020, with 472 adults with T1DM, using an online form to collect sociodemographic, mental health and physical activity data during social isolation. The Chi-Square test of independence was performed with adjusted residuals analysis (p < 0.05). A total of 51.3% of the participants remained sedentary or stopped doing physical activity during the period of social isolation. There was an association between being interested in performing daily activities (p = 0.003), not feeling depressed (p = 0.001), feeling slightly irritated (p = 0.006), having slight problems with sleep (p = 0.012) and practicing physical activity. There was also an association between maintaining physical activity and not feeling depressed (p = 0.017) and feeling very slightly irritated (p = 0.040). Adults with T1DM who practiced physical activity during the period of social isolation due to the COVID-19 pandemic showed better aspects of mental health.
Informing and Sustaining Participation of Lived Experience in the Suicide Prevention Workforce
Authors: Hawgood Jacinta , Rimkeviciene Jurgita , Gibson Mandy , McGrath Martina , Edwards Bronwen , Ross Victoria , Kresin Tracee , Kolves Kairi
Published: February 2023

Background: Currently, there is no comprehensive study focused on identifying what is needed to support ongoing participation within the suicide prevention lived experience workforce (LEW). It is unclear what specific factors may impede or support ongoing participation in the LEW. The aim of this study was to explore the experiences of suicide prevention LEW in terms of its sustainability. Method: A qualitative interview method was utilised, with a purposive sample of participants who had engaged in the LEW for at least 12 months. The sample comprised 13 individuals (nine females, four males) who engaged in multiple LEW roles, with over half (54%) working in the LEW for more than 5 years. Data were analysed using thematic analysis. Results: Five main themes were identified: support, passion, personal impact, training, and work diversity. Each theme offers perspectives about the challenges participants face within the suicide prevention LEW. Conclusion: Challenges faced are both similar to those found in the broader MH sector and unique to suicide prevention. Findings suggest that managing expectations of the LEW is important and can inform the creation of guidelines for a supported and sustainable suicide prevention LEW.
Analysis of the Return to Work Program for Disabled Workers during the Pandemic COVID-19 Using the Quality of Life and Work Ability Index: Cross-Sectional Study
Authors: Kurnianto Arie Arizandi , Fehér Gergely , Tololiu Kevin Efrain , Wikurendra Edza Aria , Nemeskéri Zsolt , Ágoston István
Published: February 2023

Background: Occupational accidents are rising, but there is little evidence on the outcomes of patients who received case management during Return to work (RTW) programs. This study examined the case management-based on RTW program features that improve the work ability index (WAI) and quality of life (QoL). Methods: This cross-sectional research involved 230 disabled workers due to an occupational injury in Indonesia, 154 participated in RTW, and 75 did not participate in RTW (non-RTW) during the COVID-19 pandemic. Sociodemographic and occupational factors were used to examine the RTW results. We used the Finnish Institute of Occupational Health’s WAI questionnaires to measure the work ability index and World Health Organization Quality of Life Brief Version (WHOQOL-BREF) for quality of life. Results: The study found a statistically significant difference in working duration and preferred treatment for RTW between the groups (p-value = 0.039). Furthermore, the quality of life in the domain of environmental health and work ability index score also demonstrated a significant difference between the groups (p-value = 0.023 and 0.000, respectively). Conclusions: During the COVID-19 pandemic, this study found that the RTW program improved the quality of life and work abilities of disabled workers.
Nature-Based Restoration Simulation for Disaster-Prone Coastal Area Using Green Infrastructure Effect
Authors: Song Kihwan , Seok Youngsun , Chon Jinhyung
Published: February 2023

Floods in coastal areas are caused by a range of complex factors such as typhoons and heavy rainfall, and this issue has become increasingly serious as interference has occurred in the social-ecological system in recent years. Given the structural limitations and high maintenance costs of the existing gray infrastructure, the need for a nature-based restoration plan utilizing green infrastructure has been raised. The purpose of this study is to simulate the restoration process through the quantification of green infrastructure effects along with resilience in disaster-prone coastal areas, and to present it as nature-based restoration planning. For this purpose, first, a disaster-prone area was derived from Haeundae-gu, Busan, Republic of Korea, which was affected by typhoons. In order to simulate the runoff from typhoon “Chaba” in the target area and the effects of reducing the runoff of green infrastructure, relevant data was collected and a model constructed. Finally, the effects of the green infrastructure as applied to the disaster-prone area were quantified by means of resilience and a nature-based restoration plan was presented. As a result of this study, first, the runoff reduction effect was greatest when the maximum biotope area ratio of 30% was applied to the artificial ground. In the case of the green roof, the effect was the greatest 6 h following the typhoon passing through, and the effects of the infiltration storage facility was greater 9 h following the same. Porous pavement exhibited the lowest runoff reduction effect. In terms of resilience, it was found that the system was restored to its original state after the biotope area ratio of 20% was applied. This study is significant in that it analyzes the effects of green infrastructure based upon the concept of resilience and connects them to nature-based restoration planning. Based on this, it will be provided as an important tool for planning policy management to effectively respond to future coastal disasters.
Introduction of Alternative Proteins for Health Professionals’ Diet: The Transtheoretical Model and Motivational Interviewing of Nutritional Interventions
Authors: Tsampoula Iliana , Kelesi Martha , Papathanasiou Ioanna V. , Thanasa Georgia , Goula Aspasia , Papageorgiou Dimitrios , Kaba Evridiki
Published: February 2023

The World Health Organization has documented the impact that a balanced diet has on disease prevention. Overconsumption of meat can lead to obesity, arteriosclerosis, thrombosis, type 2 diabetes and many life-threatening diseases. A new group of proteins has currently emerged in the scientific community of alternative nutrition called “alternative proteins”. Several interventions have been introduced by a large number of healthcare providers in order to promote and enhance people’s dietary habits. Two of the most prevalent models of health-related behaviour modification are the transtheoretical—stages of change—model (TM) and motivational interviewing (MI). The purpose of this study is to research and examine how the ΤΜ and MI could be effectively implemented in the diet of health professionals through alterations of eating habits. The population of the study is to comprise health professionals from «AΤΤΙΚOΝ» University General Hospital, Athens, Greece. The sample of participants is to be selected by the professional environment of the researcher. Participants, through random selection, are to be divided into two groups: the control group, consisting of 50 individuals, and the intervention group, consisting of 50 individuals. The duration of the study is to be from November 2022 to November 2024. The present study is concerned with productive mixed—quantitative and qualitative—evolutionary research along with the application testing of both the ΤΜ and the MI. It is to be conducted specifically on health professionals via self-administered questionnaires and semi-structured interviews.
Association between Dietary Fatty Acid Intake and Liver Steatosis and Fibrosis in a Sample of Mexican-Origin Hispanic Adults with Overweight or Obesity
Authors: Lopez-Pentecost Melissa , Hallmark Brian , Thomson Cynthia A. , Chilton Floyd , Garcia David O.
Published: February 2023

Rates of non-alcoholic fatty liver disease (NAFLD) vary dramatically among Hispanic subpopulations, with Mexican-origin (MO) Hispanics experiencing a disproportionate burden. This study examined dietary fatty acid (FA) intake among overweight and obese MO Hispanic adults in the United States (US) and evaluated its association with liver steatosis and fibrosis. Participants (N = 285, MO Hispanic adults) completed 24-h dietary recalls to assess dietary FA exposure. Liver steatosis and fibrosis were estimated using transient elastography (FibroScan®). Multiple regression analysis tested relationships between FA intakes and liver steatosis or fibrosis, adjusting for age, sex, body mass index (BMI) and total energy. A total of 51% (n = 145) of participants were suspected to have NAFLD and 20% self-reported a type 2 diabetes diagnosis. No significant association was observed between Linoleic Acid and α-Linolenic Acid (LA:ALA) ratio, or omega-6 to omega-3 (n-6:n-3) ratio and liver steatosis. However, a one-point increase in the LA:ALA ratio resulted in a 1.01% increase in the liver fibrosis scores (95% CI: [1.00, 1.03]; p = 0.03), and a one-point increase in the n-6:n-3 ratio resulted in a 1.02% increase in liver fibrosis score (95% CI: [1.01, 1.03]; p = 0.01). Further research is needed to determine if modulation of FA intake could reduce NAFLD risk in this high-risk population.