bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impacts of Removing Fossil Fuel Subsidies and Increasing Carbon Taxation in Ireland
Authors: de Bruin Kelly , Yakut Aykut Mert
Published: July 2023

Though the magnitude of fossil fuel subsidies eclipses carbon pricing revenues, policies and economic literature focus on carbon taxation. This paper aims to show that removing fossil fuel subsidies can reduce emissions as much as carbon taxation without making producers and consumers worse off. Using a dynamic intertemporal CGE model of Ireland, we compare removing eight Irish fossil fuel subsidies and increasing the carbon tax to €100 per tonne by 2030. We find that both policies result in similar emission reductions. Carbon taxation results in lower negative GDP and investment impacts, whereas subsidy removal results in lower negative employment impacts, higher revenues, an improved trade balance and lower debt. The impacts across sectors and households are distributed more evenly under a carbon tax, where subsidy removal results in extreme impacts for specific sectors and households. Excluding households’ subsidies from removal can alleviate these household distributional impacts at no cost to emission reduction. With revenue recycling reducing tax rates, a double-dividend is found at the expense of worsened income distribution. The economic benefit of revenue recycling is greater when removing subsidies than with carbon taxation and results confirm the importance of fossil fuel subsidies in climate policy.
Prevalence of Number, Number Relations, and Number Operations Indicators in State Early Learning Standards
Authors: Gable Sara , Fozi Afiah Mohd
Published: July 2023

State Early Learning Standards (ELS) are multi-function tools that inform early childhood instruction and practices. Using an established framework of early numerical development, this study assessed the prevalence of number, number relations, and number operations indicators in ELS, specifically indicators of counting, numeral knowledge, cardinality, relations among quantity and number, and operations. The type of quantity representation and the set sizes, or upper limits, assigned to counting, subitizing, and cardinality were also summarized. State ELS were organized into two groups: Group 1 (n = 23) included states with one set of indicators for preschool (e.g., ages three to five years) and Group 2 (n = 27) included states with at least two sets of indicators for preschool (e.g., 36 to 48 months and 48 to 60 months). Key findings include: (1) how states organize their ELS is associated with level of consensus for the upper limits and set sizes associated with counting and cardinality; (2) notable variability in the prevalence of early number indicators with gaps for indicators of advanced counting, cardinal principle knowledge, symbolic number relations, and ordering; and, (3) differences in how ELS address the type of quantity representation. Results are intended to highlight strengths and shortcomings of state ELS for number, number relations, and number operations and to offer considerations for future revisions.
Infection and Vaccine Induced Spike Antibody Responses Against SARS-CoV-2 Variants of Concern in COVID-19-Naïve Children and Adults
Authors: Pillay Aleha , Yeola Avani , Tea Fiona , Denkova Martina , Houston Samuel , Burrell Rebecca , Merheb Vera , Lee Fiona X. Z. , Lopez Joseph A. , Moran Lilly , Jadhav Ajay , Sterling Katrina , Lai Catherine L. , Vitagliano Tennille L. , Aggarwal Anupriya , Catchpoole Dan , Wood Nicholas , Phan Tri Giang , Nanan Ralph , Hsu Peter , Turville Stuart G. , Britton Philip N. , Brilot Fabienne
Published: July 2023

Although a more efficient adaptive humoral immune response has been proposed to underlie the usually favorable outcome of pediatric COVID-19, the breadth of viral and vaccine cross-reactivity toward the ever-mutating Spike protein among variants of concern (VOCs) has not yet been compared between children and adults. We assessed antibodies to conformational Spike in COVID-19-naïve children and adults vaccinated by BNT162b2 and ChAdOx1, and naturally infected with SARS-CoV-2 Early Clade, Delta, and Omicron. Sera were analyzed against Spike including naturally occurring VOCs Alpha, Beta, Gamma, Delta, and Omicron BA.1, BA.2, BA.5, BQ.1.1, BA2.75.2, and XBB.1, and variants of interest Epsilon, Kappa, Eta, D.2, and artificial mutant Spikes. There was no notable difference between breadth and longevity of antibody against VOCs in children and adults. Vaccinated individuals displayed similar immunoreactivity profiles across variants compared with naturally infected individuals. Delta-infected patients had an enhanced cross-reactivity toward Delta and earlier VOCs compared to patients infected by Early Clade SARS-CoV-2. Although Omicron BA.1, BA.2, BA.5, BQ.1.1, BA2.75.2, and XBB.1 antibody titers were generated after Omicron infection, cross-reactive binding against Omicron subvariants was reduced across all infection, immunization, and age groups. Some mutations, such as 498R and 501Y, epistatically combined to enhance cross-reactive binding, but could not fully compensate for antibody-evasive mutations within the Omicron subvariants tested. Our results reveal important molecular features central to the generation of high antibody titers and broad immunoreactivity that should be considered in future vaccine design and global serosurveillance in the context of limited vaccine boosters available to the pediatric population.
Adaptive piecewise linear relaxations for enclosure computations for nonconvex multiobjective mixed-integer quadratically constrained programs
Authors: Link Moritz , Volkwein Stefan
Published: July 2023

In this paper, a new method for computing an enclosure of the nondominated set of multiobjective mixed-integer quadratically constrained programs without any convexity requirements is presented. In fact, our criterion space method makes use of piecewise linear relaxations in order to bypass the nonconvexity of the original problem. The method chooses adaptively which level of relaxation is needed in which parts of the image space. Furthermore, it is guaranteed that after finitely many iterations, an enclosure of the nondominated set of prescribed quality is returned. We demonstrate the advantages of this approach by applying it to multiobjective energy supply network problems.
Treatment burden and health-related quality of life of patients with multimorbidity: a cross-sectional study
Authors: Gebreyohannes Eyob Alemayehu , Gebresillassie Begashaw Melaku , Mulugeta Frehiwot , Dessu Etsegenet , Abebe Tamrat Befekadu
Published: July 2023

Purpose

The aim of this study was to investigate treatment burden and its relationship with health-related quality of life (HRQoL) among patients with multimorbidity (two or more chronic diseases) who were taking prescription medications and attending the outpatient department of the University of Gondar Comprehensive Specialized Teaching Hospital.

Methods

A cross-sectional study was conducted between March 2019 and July 2019. Treatment burden was measured using the Multimorbidity Treatment Burden Questionnaire (MTBQ), while HRQoL was captured using the Euroqol-5-dimensions-5-Levels (EQ-5D-5L).

Results

A total of 423 patients participated in the study. The mean global MTBQ, EQ-5D index, and EQ-VAS scores were 39.35 (± 22.16), 0.83 (± 0.20), and 67.32 (± 18.51), respectively. Significant differences were observed in the mean EQ-5D-Index (F [2, 81.88] 33.1) and EQ-VAS (visual analogue scale) scores (F [2, 75.48] = 72.87) among the treatment burden groups. Follow up post-hoc analyses demonstrated significant mean differences in EQ-VAS scores across the treatment burden groups and in EQ-5D index between the no/low treatment burden and high treatment burden, as well as between the medium treatment burden and high treatment burden. In the multivariate linear regression model, every one SD increase in the global MTBQ score (i.e., 22.16) was associated with a decline of 0.08 in the EQ-5D index (β − 0.38, 95%CI − 0.48,  − 0.28), as well as a reduction of 9.4 in the EQ-VAS score (β − 0.51, 95%CI -0.60, − 0.42).

Conclusion

Treatment burden was inversely associated with HRQoL. Health care providers should be conscious in balancing treatment exposure with patients’ HRQoL.
The impact of interlingual correspondences on cognate recognition in Slavic intercomprehension
Authors: Saturno Jacopo
Published: July 2023

The present paper is devoted to the problem of cognate recognition in an intercomprehension setting, in which the target language is not directly known to the readers, but is closely related to their native language. Previous research has shown that once context is accounted for, intelligibility is partially predicted by measures of interlingual proximity such as Levenshtein distance. Taken alone, however, such measures are insufficient to fully explain empirical data. It has thus been suggested that specific interlingual correspondences may have a more conspicuous impact than others. To verify this hypothesis, 163 East Slavic-speaking learners of L2 Polish were asked to translate a set of non-words, obtained by manipulating a set of Russian words with respect to a single segment (e.g. initial consonant). All non-words were consistent with Polish phonotactics; however, some modifications matched existing phonological correspondences between Polish and Russian, while others did not. Target items were presented in writing through an online survey, initially in isolation, subsequently within a meaningful sentence.

The results show that the presence of a meaningful context significantly improves the chances of cognate recognition. Further, non-words containing systematic sound correspondences resulted in a higher recognition rate than non-words comprising arbitrary modifications. Within the latter group, finally, modifications to consonants in word-initial and word-medial position as well as diverging positions of the stress resulted in significantly lower recognition scores.
Digitalization and trade participation of SMEs
Authors: Añón Higón Dolores , Bonvin Daniel
Published: July 2023

This study examines the impact of digitalization on the participation of small and medium-sized enterprises (SMEs) in export and import activities. Using data on Spanish manufacturing SMEs from 2001 to 2014, we construct a multidimensional firm-level index of digitalization. We then estimate a set of dynamic models analyzing the direct and indirect (via total factor productivity) effects of digitalization on firms’ export and import strategies. We find evidence that firms’ digitalization positively influences the probability of exporting and importing, both directly and through productivity. We find that productivity has a stronger impact on SMEs’ trade behavior than the direct channel of digitalization. A one standard deviation increase in the digitalization index increases the probability of exporting and importing by 1.5 and 0.8 percentage points, respectively, while the same increase in the logarithm of productivity has a three times greater effect for exporting and nine times greater for importing.
“I wish I could say, ‘Yeah, both the same’”: Cultural stereotypes and individual differentiations of preservice teachers about different low socioeconomic origins
Authors: Yendell Oscar , Claus Carolina , Bonefeld Meike , Karst Karina
Published: July 2023

Previous studies have shown that (preservice) teachers have more negative stereotypes toward students from lower socioeconomic backgrounds than toward students from higher socioeconomic backgrounds. School-specific studies on different low socioeconomic origins have been non-existent so far. Evidence collected in non-school settings shows that welfare recipients are stereotyped more negatively than the working poor. This mixed methods study therefore surveyed cultural stereotypes and individual constructions of difference concerning the working poor and welfare recipients by German preservice teachers. In the quantitative study (N = 196), more stereotypes were mentioned in relation to welfare recipients than to the working poor, and more negative and fewer positive stereotypes were mentioned in relation to welfare recipients. In addition to social status, the individual characteristics (e.g., commitment) of welfare recipients were more frequently stereotyped negatively than those of the working poor. In the qualitative interview study (N = 10), preservice teachers reported that the general public perceives welfare recipients more negatively than the working poor. Preservice teachers who obtain their information about welfare recipients from public perception attributed individual failure (e.g., low commitment) as the cause for welfare recipients and structural failure (e.g., incorrect decisions by policy-makers) as the cause for the working poor. Other preservice teachers disagreed with the negative public perception based on personal experience and described welfare recipients as only being in a worse social position than the working poor. The results of the mixed methods study reveal the need to distinguish between different low socioeconomic origins in future stereotype studies.
Deep Corner
Authors: Zhao Shanshan , Gong Mingming , Zhao Haimei , Zhang Jing , Tao Dacheng
Published: July 2023

Recent studies have shown promising results on joint learning of local feature detectors and descriptors. To address the lack of ground-truth keypoint supervision, previous methods mainly inject appropriate knowledge about keypoint attributes into the network to facilitate model learning. In this paper, inspired by traditional corner detectors, we develop an end-to-end deep network, named Deep Corner, which adds a local similarity-based keypoint measure into a plain convolutional network. Deep Corner enables finding reliable keypoints and thus benefits the learning of the distinctive descriptors. Moreover, to improve keypoint localization, we first study previous multi-level keypoint detection strategies and then develop a multi-level U-Net architecture, where the similarity of features at multiple levels can be exploited effectively. Finally, to improve the invariance of descriptors, we propose a feature self-transformation operation, which transforms the learned features adaptively according to the specific local information. The experimental results on several tasks and comprehensive ablation studies demonstrate the effectiveness of our method and the involved components.
Personal Networks and Grassroots Election Participation in China: Findings from the Chinese General Social Survey
Authors: Hao Mingsong , Ke Xiwang
Published: July 2023

Grassroots elections of rural village heads and urban community directors are an important public arena for social-political participation of Chinese citizens. Analyzing the Chinese General Social Survey (CGSS2017) data through the models of GSEM (general equation structure modeling) and fulfilling the robustness check via IV (instrumental variable) method (including IV-Probit and 2SLS-IV models), this article examines the direct and indirect effects of personal networks on voting participation after 2012 under the leadership of Xi. We find that people with greater amounts of network resources and higher frequencies of social eating with network members have a higher likelihood to participate in elections. As to mediating effects, the two measures of personal networks pave the way for people to participate in formal networks of associational engagement, which in turn increase their participation in elections; however, people with higher values in the two personal network measures tend to have lower levels of institutional trust, which in turn hinders voting participation. In comparison, the positive effects are more powerful than the negative ones, so on the whole, personal networks are acting as an important conducive force for grassroots election participation.
Monitoring of banana’s optical properties by laser light backscattering imaging technique during drying
Authors: Siyum Zinabu Hailu , Pham Tung Thanh , Vozáry Eszter , Kaszab Tímea , Nguyen Lien Le Phuong , Baranyai László
Published: July 2023

Banana drying is an important process that used to extend the shelf life and increase the marketability of the dried banana. However, this process can lead to changes in weight loss, firmness, and color, which may influence consumer acceptance. As a result, it is crucial to monitor these changes to maintain the desired quality. Therefore, the aim of this study was to assess the quality of sliced bananas during the drying process by simultaneously monitoring their optical and physical properties using laser light backscatter imaging, near-infrared spectroscopy, and electrical impedance spectroscopy techniques. Banana sliced were prepared with 10 mm thickness and immersed into 4% ascorbic acid solution and water as treated and control samples dried at 50 °C for 6 h. The parameters measured were weight loss, color, firmness, NIR absorbance in the range from 740 to 1700 nm and electrical impedance in the frequency range from 30 kHz to 1 MHz. Absorption, reduced scattering and diffusion coefficients, penetration depth and full width at half maximum (FWHM) were computed on the LLBI signal at wavelengths of 532, 635, 780, 808, 850 and 1064 nm. The results showed that both the drying time and the ascorbic acid treatment and their interaction affected the measured values. The strong NIR absorption spectrum changes observed at wavelengths of 1064 and 1416 nm. The least squares partial regression model (PLSR) was performed with high accuracy for weight loss (%) and relaxation time (ms) at a coefficient of determination (R2) of 0.940 and 0.945 with a mean square error (RMSE) of 3.748 and 0.001, respectively. The electrical impedance spectral changes were found in the frequency range from 60 Hz to 1 MHz. The most sensitive laser wave lengths to evaluate optical properties were 532, 635, 780 and 1064 nm. Therefore, laser backscatter imaging together with NIR spectroscopy and impedance spectroscopy is a promising technique to assess the quality of sliced bananas during the drying process.

Graphical abstract
Qualität und Qualitätssicherung in der strafrechtsrelevanten Begutachtungspraxis
Authors: Wertz Maximilian , Rettenberger Martin , Brettel Hauke
Published: July 2023

Gutachten zu Schuldfähigkeit und Kriminalprognose stehen nicht zuletzt deshalb im öffentlichen und gesellschaftspolitischen Fokus, weil sie in hochbrisante Entscheidungen einfließen und Fehler dramatische Folgen wie ungerechtfertigte Freiheitsbeschränkungen oder Opfergefährdungen haben können. Aufgrund zahlreicher Hinweise auf Qualitätsmängel wurden Maßnahmen im Dienst der Qualitätssicherung wie die Publikation von Mindestanforderungen bzw. Empfehlungen für Prognose- und Schuldfähigkeitsgutachten etabliert. Aktuelle empirische Studien im Rahmen eines iterativen Forschungsprojekts legen anhand einer retrospektiven Analyse von über 1000 Gutachten eine zunehmende Standardisierung sowie Orientierung der Begutachtung an qualitätssichernden Kriterien und Standards nahe, weisen jedoch auch auf eine nach wie vor bestehende qualitative Heterogenität in der Begutachtungspraxis hin. Auch wenn Mindestanforderungen und Empfehlungen nicht zwangsläufig institutionsübergreifende und zeitnahe Effekte erwarten lassen, liefern im Folgenden dargestellte Befunde Anhaltspunkte dafür, dass qualitätssichernde Maßnahmen die Begutachtungspraxis positiv beeinflussen, wobei auch seitens der Auftraggeber qualitätssichernde Potenziale festzustellen sind. Die Ergebnisse sprechen einerseits für einen (Teil‑)Erfolg, andererseits verdeutlichen sie weiteren Handlungsbedarf im Hinblick auf die Qualitätssicherung bei der Erstellung von Prognose- und Schuldfähigkeitsgutachten.
Verselbstständigung als eine zentrale Herausforderung des Jugendalters
Authors: Berngruber Anne , Herz Andreas
Published: July 2023

An junge Menschen werden gesellschaftliche Erwartungen (beispielsweise aus dem Elternhaus auszuziehen, ökonomisch selbstständig zu werden) gestellt, die sie im Prozess des Erwachsenwerdens erfüllen und mitgestalten (sollen). Unter Verselbstständigung wird in dem Beitrag auf Grundlage der AID:A 2019 und 2021 Befragungen beschrieben, wann zentrale Ereignisse im Jugendalter stattfinden und welchen Einfluss die Coronapandemie darauf genommen hat.
Genetic Architecture and Functional Implications of the CSF-Contacting Nucleus
Authors: Song Siyuan , Yuan Yumin , Xu Lingling , Jiang Jun , Li Ying , Yan Yao , Li Qing , Zhou Fang , Cao Junli , Zhang Licai
Published: July 2023

We previously identified a unique nucleus, the cerebrospinal fluid (CSF)-contacting nucleus. This study aims to understand its gene architecture and preliminarily suggest its functions. The results showed that there were about 19,666 genes in this nucleus, of which 913 were distinct from the dorsal raphe nucleus (non-CSF contacting). The top 40 highly-expressed genes are mainly related to energy metabolism, protein synthesis, transport, secretion, and hydrolysis. The main neurotransmitter is 5-HT. The receptors of 5-HT and GABA are abundant. The channels for Cl–, Na+, K+, and Ca2+ are routinely expressed. The signaling molecules associated with the CaMK, JAK, and MAPK pathways were identified accurately. In particular, the channels of transient receptor potential associated with nociceptors and the solute carrier superfamily members associated with cell membrane transport were significantly expressed. The relationship between the main genes of the nucleus and life activities is preliminarily verified.
Convergent evolution of defensive appendages – a lithobiomorph-like centipede with a scolopendromorph-type ultimate leg from about 100 million-year-old amber
Authors: Haug Gideon T. , Haug Joachim T. , Haug Carolin
Published: July 2023

Centipedes are predatory representatives of the group Myriapoda and important components of the soil and leaf-litter fauna. The first pair of trunk appendages is modified into venom-injecting maxillipeds in all centipedes. The number of trunk appendage pairs varies between the different groups of centipedes, from 15 pairs as apparently ancestral (plesiomorphic) condition, up to 191 pairs. The last pair of trunk legs can be used for different tasks in centipedes, e.g. mechano-sensation, defense, or stridulation. Many morphological details are also known from fossil centipedes, but especially the oldest fossils are often fragmentary and the fossil record in general is rather scarce. Especially the late appearance of lithobiomorphans in Cenozoic ambers is notable, though some not formally described lithobiomorph-like specimens from Cretaceous amber from Myanmar have been published. We present here a new specimen from Cretaceous Kachin amber, Myanmar with a lithobiomorph-type of morphology, Lithopendra anjafliessae gen. et sp. nov. The very large ultimate leg appears to have been used for defence and is, in relative proportions, larger than in any known lithobiomorphan, only comparable to that in scolopendromorphans. With this, the specimen presents a mixture of characters, which are in the modern fauna only known from two different centipede groups. We discuss the implications of this new fossil, also concerning events of convergence in this lineage.
Unsteady evolution of distributed roughness-induced vortices under re-entry conditions
Authors: Ulrich Friedrich , Stemmer Christian
Published: July 2023

This study investigates a re-entry scenario of an Apollo-like space capsule with Direct Numerical Simulations (DNS). The simulation includes the chemical equilibrium gas model. Cross-flow-like vortices are induced through random distributed roughness patches on the capsule surface. Two different machine learning methods are used to predict the maximum vorticity magnitude downstream of a pseudo-random roughness patch, the wall-normal location of the vortex core and spanwise and wall-normal gradient maxima of u. A large DNS database is formed for training and testing of the neural networks. In order to understand the influence of the vorticity magnitude on the transition process, local one-dimensional inviscid (LODI) relations are used to describe perturbations at the inflow. The disturbance evolution in the streamwise direction is analysed with a two-dimensional Fourier transformation in time and space. We show how the vorticity magnitudes of the cross-flow-like vortices, spanwise and wall-normal derivatives of the streamwise velocity influence the transition location.
Architecture and Evaluation of an Advanced Legal Information Platform—Enhancing Productivity of Modern Legal Work
Authors: Alexopoulos Charalampos , Loukis Euripidis , Virkar Shefali
Published: July 2023

It is widely recognized that legislation is of critical importance for the proper functioning of economies and societies. However, the increasing complexity of the problems and challenges faced by modern economies and societies have resulted in the development of extensive, highly complex, and continuously evolving legislations. This makes it difficult for firms and administrations, as well as individual lawyers and public servants, to know the current applicable legislation on a particular topic of interest, as well as its evolution over time. This difficulty increases further due to the internationalization–globalization of economic activity, as well as the development of supranational organizations (such as the European Union (EU)), which make it necessary to continuously monitor legislations of several countries on various topics of interest. Existing national legal information platforms cannot satisfy the above highly complex requirements. This paper contributes to filling this gap, initially by describing the architecture and the capabilities/functionalities of an advanced “international” legal information platform, which has been developed as part of the European research program “ManyLaws,” based on requirements collected through interviews with lawyers and public servants; it enables the advanced search and retrieval of relevant legal documents on a particular topic of interest from within the legislative corpuses of many different countries, as well as EU legislation, using existing sources of open legal information, and also the automated comparative analysis of them and identification of various types of relations among them. The evaluation of this advanced legal information platform, using an extension of the Technology Acceptance Model (TAM), provides evidence of the usefulness and the ease of use of its novel functionalities, as well as their positive contribution to the productivity of both national-level legal work and international-level legal work, especially within the EU. The proposed advanced legal information platform can be quite useful for firms and administrations, as well as individual lawyers and public servants, active in the modern globalized economic context.
Spatial Autocorrelation of Exports and R&D Expenditures in Portugal
Authors: de Campos Antonio Carlos , Lopes Luís , Carreira Carlos
Published: July 2023

This article analyzes spatial autocorrelations and the formation of clusters of exports, based on research and development (R&D) intensity in Portugal. The central idea is that exports show relative interdependence and spillover effects among nearby regions and a direct relationship with R&D expenditures. It adopts the new taxonomy of the OECD, separating exports by manufacturing and non-manufacturing activities by technological intensity. Methodologically, it applied exploratory spatial data analysis (ESDA), using global Moran’s index and LISA. The results showed the presence of positive spatial autocorrelation of exports and the formation of a cluster of the high–high type for the Área Metropolitana do Porto and Região de Aveiro. There is also a positive spatial autocorrelation for exports associated with R&D expenditures as well as the formation of a regional cluster with high–high pattern for the Região de Aveiro. This outcome can be explained, in part, by nationally and internationally recognized universities and research centers surrounding the region, favoring knowledge spillovers across the regions.
Recent Progress of Layered Perovskite Solar Cells Incorporating Aromatic Spacers
Authors: Gao Yuping , Dong Xiyue , Liu Yongsheng
Published: July 2023

Layered two dimensional (2D) or quasi-2D perovskites are emerging photovoltaic materials due to their superior environment and structure stability in comparison with their 3D counterparts. The typical 2D perovskites can be obtained by cutting 3D perovskites along  < 100 >  orientation by incorporation of bulky organic spacers, which play a key role in the performance of 2D perovskite solar cells (PSCs). Compared with aliphatic spacers, aromatic spacers with high dielectric constant have the potential to decrease the dielectric and quantum confinement effect of 2D perovskites, promote efficient charge transport and reduce the exciton binding energy, all of which are beneficial for the photovoltaic performance of 2D PSCs. In this review, we aim to provide useful guidelines for the design of aromatic spacers for 2D perovskites. We systematically reviewed the recent progress of aromatic spacers used in 2D PSCs. Finally, we propose the possible design strategies for aromatic spacers that may lead to more efficient and stable 2D PSCs.
Application of Human Induced Pluripotent Stem Cells for Tissue Engineered Cardiomyocyte Modelling
Authors: Katili Puspita A. , Karima Amira P. , Azwani Winda , Antarianto Radiana D. , Djer Mulyadi M.
Published: July 2023

Purpose

Cardiac
tissue engineering opens up opportunities for regenerative therapy in heart diseases. Current technologies improve engineered cardiac tissue characteristics by combining human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with non-cardiomyocytes, selective biomaterials, and additional growth factors. Animal models are still required to determine cardiac patches’ overall in vivo effect before initiating human trials. Here, we review the current in vivo studies of cardiac patches using hiPSC-CMs.

Methods

We performed a literature search for studies on cardiac patch in vivo application and compared outcomes based on cell engraftment, functional changes, and safety profiles.

Results

Present studies confirm the beneficial results of combining hiPSC-CMs with other cardiac cell lineages and biomaterials. They improved the functional capacity of the heart, showed a reduction in infarct size, and initiated an adaptive inflammatory process through neovascularisation.

Conclusion

The cardiac patch is currently the most effective delivery system, proving safety and improvements in animal models, which are suggested to be the role of the paracrine mechanism. Further studies should focus on honing in vitro patch characteristics to achieve ideal results.

Lay Summary

Cardiac tissue engineering answers the demand for regenerative therapy in heart diseases. Combining human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) with biomaterials and growth factors in cardiac patches improves the heart’s structural and functional characteristics. This delivery system is safe and efficient for delivering many cells and minimising cellular loss in vivo. Rat and porcine models of ischemic and non-ischemic heart diseases demonstrated the benefits of this therapy, which include cell engraftment, reduced infarct size, and increased left ventricular (LV) systolic function, with no reported critical adverse events. These reports sufficiently provide evidence of feasible improvements to proceed towards further trials.
Gendering Counter-Terrorism: Kunya and the Silencing of Male Victims of CRSV in Northeastern Nigeria
Authors: Njoku Emeka Thaddues , Dery Isaac
Published: July 2023

As the silence of male CRSV victims continues to be debated, some argue that gender norms and a lack of agency contribute to the silence of victims, even as others assert that victims exercise agency by speaking selectively about their experiences. In northern Nigeria, the concept of kunya—a model for appropriate behaviour rooted in the importance of secrecy and discretion—plays a role in the silencing of victims. We examine how kunya contributes to the invisibility of victims and influences their silence, as well as how victims use silence to gain social tolerability and/or protect themselves from re-victimization. We argue that an attentiveness to such community-specific cultural precepts and norms can further our understanding of the silence (and silencing) of victims and survivors.
Statistical constraints on climate model parameters using a scalable cloud-based inference framework
Authors: Carzon James , Abreu Bruno , Regayre Leighton , Carslaw Kenneth , Deaconu Lucia , Stier Philip , Gordon Hamish , Kuusela Mikael
Published: July 2023

Atmospheric aerosols influence the Earth’s climate, primarily by affecting cloud formation and scattering visible radiation. However, aerosol-related physical processes in climate simulations are highly uncertain. Constraining these processes could help improve model-based climate predictions. We propose a scalable statistical framework for constraining the parameters of expensive climate models by comparing model outputs with observations. Using the C3.AI Suite, a cloud computing platform, we use a perturbed parameter ensemble of the UKESM1 climate model to efficiently train a surrogate model. A method for estimating a data-driven model discrepancy term is described. The strict bounds method is applied to quantify parametric uncertainty in a principled way. We demonstrate the scalability of this framework with 2 weeks’ worth of simulated aerosol optical depth data over the South Atlantic and Central African region, written from the model every 3 hr and matched in time to twice-daily MODIS satellite observations. When constraining the model using real satellite observations, we establish constraints on combinations of two model parameters using much higher time-resolution outputs from the climate model than previous studies. This result suggests that within the limits imposed by an imperfect climate model, potentially very powerful constraints may be achieved when our framework is scaled to the analysis of more observations and for longer time periods.
Unpartitionable: C.H. Alexandrowicz, Sovereign Divisibility, and the Longue Durée of the Polish-Lithuanian Commonwealth
Authors: Loefflad Eric
Published: July 2023

In recent years, scholars of international legal history have demonstrated much newfound interest in C.H. Alexandrowicz, a Polish jurist renowned for his anti-Eurocentric revisionist account of Asian and African agency within the meta-narrative of international law. Building on efforts to link his Polish origins with his studies of the Afro-Asian world, especially on matters of imperialism and state personality, my purpose in this Article is to explore these connections through a materially grounded historical sociology of international legal thought. Centering the issue of whether sovereignty is divisible, I situate the historic Polish-Lithuanian Commonwealth—extinguished by a series of Partitions in 1772, 1793, and 1795—as a unique divided sovereignty-based polity that provided a basis for Alexandrowicz’s study of the juridical status of non-European sovereigns. This analogy united his overarching critique of nineteenth-century international legal positivism as an unjustifiable denial of both Polish and Afro-Asian sovereignty. In deciphering the materiality of Alexandrowicz’s imagination against this presumption, I build a narrative of the Polish-Lithuanian Commonwealth and the evolution of its distinct approach to sovereign divisibility. Through analysis of the interplay between internal and external factors, I account for the Commonwealth’s medieval origins, its development in opposition to the consolidating indivisible sovereignty of its absolutist neighbors, its attempts to maintain independence in the face of Partition, and the continued assertions of its variegated legacies following its destruction. This, I argue, provides a novel means of assessing Alexandrowicz’s theory, and the materiality of international law more generally.
Linking turbulent waves and bubble diffusion in self-aerated open-channel flows: two-state air concentration
Authors: Kramer Matthias , Valero Daniel
Published: July 2023

High-Froude-number flows become self-aerated when the destabilizing effect of turbulence overcomes gravity and surface tension forces. Traditionally, the resulting air concentration profile has been explained using single-layer approaches that invoke solutions of the advection–diffusion equation for air in water, i.e. bubbles’ dispersion. Based on a wide range of experimental evidence, we argue that the complete air concentration profile shall be explained through the weak interaction of different canonical turbulent flows, namely a turbulent boundary layer (TBL) and a turbulent wavy layer (TWL). Motivated by a decomposition of the streamwise velocity into a pure wall flow and a free-stream flow (Krug et al., J. Fluid Mech., vol. 811, 2017, pp. 421–435), we present a physically consistent two-state formulation of the structure of a self-aerated flow. The air concentration is mathematically built upon a modified Rouse profile and a Gaussian error function, resembling vertical mass transport in the TBL and the TWL. We apply our air concentration theory to over 500 profiles from different data sets, featuring excellent agreement. Finally, we show that the turbulent Schmidt number, characterizing the momentum-mass transfer, ranges between 0.2 and 1, which is consistent with previous mass-transfer experiments in TBLs. Altogether, the proposed flow conceptualization sets the scene for more physically based numerical modelling of turbulent mass diffusion in self-aerated flows.
Movement versus Party: The Electoral Effects of Anti-Far Right Protests in Greece
Authors: ELLINAS ANTONIS A. , LAMPRIANOU IASONAS
Published: July 2023

The way social protest affects electoral outcomes remains a lacuna. This article helps fill this gap by examining how social protest against far right actors affects their electoral standing. The article utilizes a unique dataset of 4,745 local protest events to investigate how mobilization against the far right in Greece affected its electoral performance. The article finds that protest activity depressed the electoral results of the far right Golden Dawn by as much as 16%, after controlling for a number of important variables. The article identifies and specifies the patterns through which protests against the far right affect its electoral standing. Protests are effective when following the “tango” pattern—when there is close interaction of far right and anti-far right events. The timing of protest is also important and the article shows how the synchronization of protest and electoral cycles affects electoral outcomes. The article uses the findings to discuss the varying impact of protest across electoral cycles.
Constraining the evolution of shear zones in the Himalayan mid crust in Central–Western Nepal: implications for the tectonic evolution of the Himalayan metamorphic core
Authors: Carosi Rodolfo , Montomoli Chiara , Iaccarino Salvatore , Cottle John M. , Massonne Hans-Joachim , Nania Laura , Simonetti Matteo
Published: July 2023

Structural analysis, petrochronology and metamorphic petrology enable identification and bracketing of the timing of a newly mapped high-temperature ductile shear zone (Jagat Shear Zone (JSZ)) in the Himalayan metamorphic core in Central-Western Nepal. In situ U-Th-Pb monazite petrochronology constrains the timing of top-to-the-S/SW shearing between 28–27 Ma and 17 Ma. Burial and prograde metamorphisms in footwall rocks were linked to thrust-sense movement along the JSZ, while the hanging wall rocks were retrogressed and exhumed. The identification and age of the JSZ (as part of a regional system of shear zones: the High Himalayan Discontinuity (HHD)) coupled with the localization and timing of activity of the Main Central Thrust (MCT) (i) fills a gap in tracing the HHD along orogenic strike, (ii) supports the identification of the position and timing of the long-debated MCT and (iii) helps to place the boundaries of the Himalayan metamorphic core and its internal architecture. Thus, our study is a significant step towards a precise identification of the burial, assembly and exhumation mechanisms of the Himalayan metamorphic core.
The Scottish Enlightenment and the Remaking of Modern History
Authors: Pye Tom
Published: July 2023

This article offers a new interpretation of the history-writing produced in Enlightenment Scotland. It argues that after the Jacobite rebellion of 1745 was blamed on Scotland's ‘feudal’ institutions, Scottish jurists and historians began to interrogate what it meant to become 'modern'. Instead of accepting the Whig claim that England provided the ideal model for social and political development, they subsumed English history into a broader debate about whether and how modern Europe had emerged from its feudal past. By reconstructing this debate, the article shows how Scots rewrote European history in ways that subverted the English whig tradition while rejecting universal or ‘cosmopolitan’ explanations of social progress. In doing so, the article reopens the question of how the Scottish Enlightenment shaped British imperial culture across the eighteenth and early nineteenth centuries.
‘It’s always difficult for women’: an analysis of the life stories of sub-Saharan migrant women
Authors: Gutiérrez-García Ana Isabel , Jiménez-Ruiz Ismael , Siles-González José , Perpiñá-Galvañ Juana , Solano-Ruíz Carmen
Published: July 2023

The aim of this study was to understand the perspectives of female residents of Spain from West Africa in terms of the factors that condition their lives. Pierre Bourdieu’s theory and the model of intersectionality formed the framework we used to qualitatively analyse the life stories of these women, which was complemented with life lines. The results showed us that traditional practices such as female genital mutilation and forced marriage are part of the social habitus of this group and they relate to each other through the several types of violence that occurs throughout their lives. In addition, in reference to the African community, these women were no longer African, while in terms of the Spanish community, they did not seem Spanish. At a health, political, and social level, this knowledge can help us to understand this group and to create personalised targeted interventions for them.
Coronavirus disease 2019 pandemic telephone two-week-wait referrals in head and neck cancer – how safe were they?
Authors: Lau Kin Lun , Wilson Margarita , Oozeer Nashreen , Cocks Helen
Published: July 2023

Objective

During the coronavirus disease 2019 pandemic, ENT-UK recommended a move from face-to-face clinics to telephone appointments. This study reviewed the safety of telephone clinics for urgent two-week-wait cancer referrals.

Methods

Patients consulted in telephone clinics between April and November 2020 were identified from an electronic database. Study patients included those diagnosed with malignant disease at six months. The Head and Neck Cancer Risk Calculator version 2 score, outcome of the initial clinic and final diagnoses were reviewed.

Results

A total of 1062 patients were triaged in clinic; 9.2 per cent (n = 98) were diagnosed with cancer at 6 months. Of these 98 patients, 69 received an urgent face-to-face appointment, 26 underwent urgent scans and 3 had a delayed telephone review. Twenty patients (20.4 per cent) diagnosed with cancer had a low-risk Head and Neck Cancer Risk Calculator score.

Conclusion

The late diagnosis rate of 0.28 per cent suggests a small proportion of cancer could have been missed. Telephone clinics, whilst a pragmatic means to maintain patient flow during the pandemic, could result in late diagnoses.
The messy practice of decolonising a concept: Everyday humanitarianism in Tanzania
Authors: Sulley Consolata Raphael , Richey Lisa Ann
Published: July 2023

This article1 explores the messy practice of decolonising a concept through collaborative work between scholars researching together the meaning of everyday humanitarianism in Tanzania. Humanitarianism is typically understood as the state-centric, formal, Northern-driven helping of distant others in crisis. Using the concept of everyday humanitarianism, our article challenges these assumptions in three ways. First, it explores the everyday humanitarian actions of ordinary citizens in times of crisis. Second, it explores these responses in a Southern context. Third, it focuses explicitly on the givers and not only the receivers of humanitarian help. Our work grounds decolonisation in the actual practices of research aimed at theory building as an iterative back-and-forth exchange with particular attention to power, rather than as a transplant of Northern theory on the South, or its opposite. Our first argument is that the objective of collaborative research to capture the local politics of giving and then use these practices to interrogate the theoretical concept of everyday humanitarianism can be decolonising. Second, we argue that the practices of the academic labour that produces knowledge or inductive theory can also be decolonising. Understanding both the challenges and the possibilities of decolonising ‘humanitarianism’ will provide an opportunity to document and thus legitimate the complexity that is inherent in decolonising a discipline.
Pan-African gender governance: The politics of aspiration at the African Union
Authors: Tornius Karmen
Published: July 2023

The African Union (AU) has developed an elaborate gender governance architecture, including gender machineries and women’s desks, policy frameworks, path-breaking women’s rights laws, and ongoing campaigns on women’s rights–related issues. At the same time, the member states’ engagement with this architecture is at best lukewarm, with a lack of domestication, compliance, and accountability. This paradox is addressed in this article by developing the theoretical thinking around aspirational politics (Martha Finnemore and Michelle Jurkovich, ‘The politics of aspiration’, International Studies Quarterly, 64:4 [2020], pp. 759–69) and political brokers (Stacie E. Goddard, ‘Brokering change: Networks and entrepreneurs in international politics’, International Theory, 1:2 [2009], pp. 249–81), showing the social and relational origins of pan-African gender governance. In doing so, the article examines how ‘aspirational politics’ can be operationalized to examine the sociocultural and political production of shared future imaginaries. The paper focuses on AU femocrats as the key actors for AU’s aspirational gender agenda and argues for their importance as political brokers between AU member states, donors, UN agencies, and civil society organisations. By mobilizing actors and facilitating common ground and agreement, their institutionalized broker position allowed for various political entrepreneurs to emerge and thrive. At the same time, their pursuits are met with ‘aspirational fatigue’ or outright contestation by the member states. The case of the AU demonstrates how aspirational politics is not a ‘phase’ leading to norms governance but part and parcel of normative negotiation and engagement.