bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Validation of a Risk Prediction Model for Frailty in Patients with Chronic Diseases
Authors: Xu Yuanchun , Cao Wei , He Zongsheng , Wu Nuoyi , Cai Mingyu , Yang Li , Liu Shuying , Jia Wangping , He Haiyan , Wang Yaling
Published: October 2024

The occurrence rate of frailty is high among patients with chronic diseases. However, the assessment of frailty among these patients is still far from being a routine part of clinical practice. The aim of this study is to develop a validated predictive model for assessing frailty risk in patients with chronic illnesses. This study recruited 543 patients with chronic diseases, and 237 were included in the development and validation of the predictive model. A total of 57 frailty related indicators were analyzed, encompassing sociodemographic variables, health status, physical measurements, nutritional assessment, physical activity levels, and blood biomarkers. There were 100 cases (42.2%) presenting frailty symptoms. Multivariate logistic regression analysis revealed that gender, age, chronic diseases, Mini Nutritional Assessment score, and Clinical Frailty Scale score were predictive factors for frailty in chronic disease patients. Utilizing these factors, a nomogram model demonstrated good consistency and accuracy. The AUC values for the predictive model and validation set were 0.946 and 0.945, respectively. Calibration curves, ROC, and DCA indicated the nomogram had favorable predictive performance. Altogether, the comprehensive nomogram developed here is a promising and convenient tool for assessing frailty risk in patients with chronic diseases, aiding clinical practitioners in screening high-risk populations.
Ischemic Stroke: Pathophysiology and Evolving Treatment Approaches
Authors: Majumder Dhriti
Published: October 2024

Stroke remains a leading cause of mortality and disability, with ischemic stroke being the most common type. It occurs due to reduced cerebral blood flow, leading to a cascade of events initiated by oxygen and nutrient deprivation, triggering excitotoxicity, oxidative stress, and inflammation and finally culminating in neuronal injury and death. Key molecular players in ischemic stroke include glutamate receptors, acid-sensing ion channels, and purinergic receptors, exacerbating cellular damage through calcium influx, oxidative stress, and mitochondrial dysfunction. Understanding these mechanisms has shaped therapeutic strategies, such as neuroprotective agents and stem cell therapies. Current treatments such as tissue plasminogen activator (tPA) emphasize timely intervention, yet challenges persist in patient-specific variability and accessibility. This review provides an overview of ischemic stroke pathophysiology, emphasizing cellular responses to ischemia and current and future therapeutic approaches including stem cell therapies aimed at mitigating stroke-induced disabilities and improving long-term outcomes.
Effect of Dexmedetomidine on Rescue Analgesic Needs in Non-intubated Intensive Care Patients
Authors: Andrei Sophie E. , Zhuo Wenxin , Shiekh Kellie N. , Reinert Justin P.
Published: October 2024

Background:

Dexmedetomidine is a centrally acting alpha-2-adrenoceptor agonist that is usually used in the intensive care unit (ICU) for its sedative, analgesic, and anxiolytic properties. Studies have shown that dexmedetomidine can be an effective adjunct analgesic, but they are limited and usually use a population of intubated patients. To better evaluate the role of dexmedetomidine use in the adult ICU, more information needs to be gathered on its analgesic effect and its utility in non-intubated patients.

Methods:

This study was a retrospective cohort analysis between adult non-intubated ICU patients on dexmedetomidine and non-intubated ICU patients not on dexmedetomidine who were admitted to a 302-bed tertiary academic medical center between October 1, 2022, and August 31, 2023. Inclusion criteria necessitated an as-needed opioid order with a corresponding pain score and at least 1 other pain assessment and no history of symptomatic bradycardia, nor could it be present on admission. The primary study objective was to assess the amount of morphine milligram equivalents (MMEs) received during ICU admission with concomitant dexmedetomidine infusion. Secondary outcomes included the time to first dose of rescue opioid analgesia and ICU length of stay.

Results:

A total of 38 patients were included. Baseline demographics did not differ significantly between groups. There was a significant statistical difference in the total amount of MMEs received, with the dexmedetomidine group having significantly less than the control group ( P < 0.001). The dexmedetomidine group also had a significantly longer time to first rescue analgesia dose ( P = 0.025) and a significantly increased incidence of delirium ( P < 0.001). There was no difference in other adverse events between groups.

Conclusion:

Dexmedetomidine significantly decreased MME requirements and increased time to first rescue analgesia dose in non-intubated ICU patients without increasing adverse effects but was associated with an increased incidence of delirium.
Modelling Method and Meshing Characteristics of a Novel Curve-Surface Conjugate Internal Gear Drive
Authors: Ye Xinxin , Zhang Luhe , Wang Dongyu , Jiang Jingming , Luo Wenjun , Chen Bingkui
Published: October 2024

Space exploration has become a major focus in the field of technology, with gear transmissions in aerospace equipment playing a crucial role. In the extreme environment of space, gear transmissions face challenges like large temperature differentials, deformation and maintenance difficulties, which will severely impact transmission accuracy and service life. To meet the growing demands for high-performance gear transmissions with high transmission efficiency and error adaptability in the aerospace field, this paper proposes a novel curve-surface conjugate internal gear drive consisting of an involute internal gear and a curve-surface gear. The fundamental theory of curve-surface conjugation is introduced, and the construction method for curve-surface gear based on a selected contact path and meshing tube is presented. The analysis models including induced curvature, sliding ratio and tooth contact analysis with errors (ETCA) are simulated to evaluate the meshing characteristics. Additionally, prototypes are manufactured and experimental setups are established to validate the transmission performance. These results indicate that as the rotational speed increases, the transmission efficiency of the curve-surface conjugate internal gear drive improves, which is contrary to the trend observed in involute gear drives. And the transmission efficiency of the curve-surface conjugate internal gear drive surpasses that of the involute gear drive at higher rotational speeds. Moreover, this novel gear drive exhibits excellent error adaptability, maintaining intact contact paths and high transmission efficiency even in the presence of assembly errors. This study provides new ideas for the design and manufacture of high-performance gear transmissions from the perspective of spatial geometric elements.
Screening of hub genes for sepsis-induced myopathy by weighted gene co-expression network analysis and protein-protein interaction network construction
Authors: Wang Jianhao , Han Kun , Lu Jinshuai
Published: October 2024

Sepsis-induced myopathy is one of the serious complications of sepsis, which severely affects the respiratory and peripheral motor systems of patients, reduces their quality of life, and jeopardizes their lives, as evidenced by muscle atrophy, loss of strength, and impaired regeneration after injury. The pathogenesis of sepsis-induced myopathy is complex, mainly including cytokine action, enhances free radical production in muscle, increases muscle protein hydrolysis, and decreases skeletal muscle protein synthesis, etc. The above mechanisms have been demonstrated in existing studies. However, it is still unclear how the overall pattern of gene co-expression affects the pathological process of sepsis-induced myopathy. Therefore, we intend to identify hub genes and signaling pathways. Weighted gene co-expression network analysis was our main approach to study gene expression profiles: skeletal muscle transcriptome in ICU patients with sepsis-induced multi-organ failure (GSE13205). After data pre-processing, about 15,181 genes were used to identify 13 co-expression modules. Then, 16 genes (FEM1B, KLHDC3, GPX3, NIFK, GNL2, EBNA1BP2, PES1, FBP2, PFKP, BYSL, HEATR1, WDR75, TBL3, and WDR43) were selected as the hub genes including 3 up-regulated genes and 13 down-regulated genes. Then, Gene Set Enrichment Analysis was performed to show that the hub genes were closely associated with skeletal muscle dysfunction, necrotic and apoptotic skeletal myoblasts, and apoptosis in sepsis-induced myopathy. Overall, 16 candidate biomarkers were certified as reliable features for more in-depth exploration of sepsis-induced myopathy in basic and clinical studies.
The endocannabinoid system in bovine tissues: characterization of transcript abundance in the growing Holstein steer
Authors: Kent-Dennis Coral , Klotz James L.
Published: October 2024

Background

The endocannabinoid system (ECS) is highly integrated with seemingly all physiological and pathophysiological processes in the body. There is increasing interest in utilizing bioactive plant compounds, for promoting health and improving production in livestock. Given the established interaction between phytochemicals and the ECS, there are many opportunities for identification and development of therapies to address a range of diseases and disorders. However, the ECS has not been thoroughly characterized in cattle, especially in the gastrointestinal tract. The objective of this study was to characterize the distribution and transcriptional abundance of genes associated with the endocannabinoid system in bovine tissues.

Methods

Tissues including brain, spleen, thyroid, lung, liver, kidney, mesenteric vein, tongue, sublingual mucosa, rumen, omasum, duodenum, jejunum, ileum and colon were collected from 10-mo old Holstein steers (n = 6). Total RNA was extracted and gene expression was measured using absolute quantification real time qPCR. Gene expression of endocannabinoid receptors CNR1 and CNR2, synthesis enzymes DAGLA, DAGLB and NAPEPLD, degradation enzymes MGLL and FAAH, and transient receptor potential vanilloids TRPV3 and TRPV6 was measured. Data were analyzed in R using a Kruskal-Wallis followed by a Wilcoxon rank-sum test. Results are reported as the median copy number/20 ng of equivalent cDNA (CN) with interquartile range (IQR).

Results

The greatest expression of CNR1 and CNR2 was in the brain and spleen, respectively. Expression of either receptor was not detected in any gastrointestinal tissues, however there was a tendency (P = 0.095) for CNR2 to be expressed above background in rumen. Expression of endocannabinoid synthesis and degradation enzymes varied greatly across tissues. Brain tissue had the greatest DAGLA expression at 641 CN (IQR 52; P ≤ 0.05). DAGLB was detected in all tissues, with brain and spleen having the greatest expression (P ≤ 0.05). Expression of NAPEPLD in the gastrointestinal tract was lowest in tongue and sublingual mucosal. There was no difference in expression of NAPEPLD between hindgut tissues, however these tissues collectively had 592% greater expression than rumen and omasum (P ≤ 0.05). While MGLL was found to be expressed in all tissues, expression of FAAH was only above the limit of detection in brain, liver, kidney, jejunum and ileum. TRPV3 was expressed above background in tongue, rumen, omasum and colon. Although not different from each other, thyroid and duodenum had the greatest expression of TRPV6, with 285 (IQR 164) and 563 (IQR 467) CN compared to all other tissues (P < 0.05).

Conclusions

These data demonstrate the complex distribution and variation of the ECS in bovine tissues. Expression patterns suggest that regulatory functions of this system are tissue dependent, providing initial insight into potential target tissues for manipulation of the ECS.
Effect of ertugliflozin on left ventricular function in type 2 diabetes and pre-heart failure: the Ertu-GLS randomized clinical trial
Authors: Lim Soo , Bae Jae Hyun , Oh Heran , Hwang In-Chang , Yoon Yeonyee E. , Cho Goo-Yeong
Published: October 2024

Background

The therapeutic effects of ertugliflozin, a sodium-glucose cotransporter 2 inhibitor, on cardiovascular outcome are not fully understood. This study aimed to evaluate the efficacy and safety of ertugliflozin on cardiac function in people with type 2 diabetes and pre-heart failure.

Methods

We conducted a 24-week randomized, double-blind, placebo-controlled trial involving individuals with type 2 diabetes inadequately controlled with antidiabetic medications. Participants with left ventricular hypertrophy, E/e’ >15, or impaired left ventricular global longitudinal strain (LVGLS) were randomized 1:1 to receive either ertugliflozin (5 mg once daily) or a placebo. The primary outcome was the change in LVGLS. Secondary outcomes included changes in left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF). Prespecified exploratory outcomes, including angiotensin-converting enzyme 2 (ACE2) and angiotensin (1–7) levels, were also assessed.

Results

A total of 102 individuals (mean age, 63.9 ± 9.2 years; 38% women) were included. The ertugliflozin group showed a significant improvement in LVGLS (− 15.5 ± 3.1% to − 16.6 ± 2.8%, P = 0.004) compared to the placebo group (− 16.7 ± 2.7% to − 16.4 ± 2.6%, P = 0.509), with a significant between-group difference (P = 0.013). Improvements in LVMI and LVEF were also observed. Additionally, significant reductions in HbA1c, systolic blood pressure, whole-body and visceral fat, uric acid, proteinuria, N-terminal pro–B-type natriuretic peptide, and lipoprotein(a) were noted. ACE2 and angiotensin (1–7) levels significantly increased in the ertugliflozin group compared to the placebo group and correlated with changes in LVGLS [r = 0.456, P < 0.001 for ACE2; r = 0.541, P < 0.001 for angiotensin (1–7)]. Adverse events were similar between the two groups.

Conclusions

This study demonstrated that ertugliflozin has beneficial effects on left ventricular function in individuals with type 2 diabetes and pre-heart failure, and it provided insights into potential underlying mechanisms.

Clinical trial registration

ClinicalTrials.gov Identifier: NCT03717194.
Molecular characterization and immunopathological investigation of Avian reticuloendotheliosis virus in breeder flocks in Egypt
Authors: Shosha Eman Abd El-Menamm , Zanaty Ali Mahmoud , Darwesh Marwa Mostafa , Fotouh Ahmed
Published: October 2024

Background

Reticuloendotheliosis virus (REV) is an oncogenic immunosuppressive retrovirus that infects different kinds of avian species; posing significant economic losses to the poultry industry worldwide.

Methods

In Egypt, there is an unidentified disease associated with the runting-stunting syndrome with neoplasia, suspected to be REV, that has been continuously monitored in several breeder flocks. To diagnose and analyze REV by cell cultures, enzyme-linked immunosorbent assay (ELISA), histopathological investigation, the polymerase chain reaction (PCR) test, and sequencing analysis, 200 blood samples, and 50 tissue specimens were collected. The current study targets the occurrence and genetic characteristics of a viral neoplastic disease, resembling REV infection, circulating in breeder flocks from 2022 to 2023 in the Ismailia, El-Sharqia, and El-Dakahliya governorates.

Result

Here, REV was isolated on chicken embryo fibroblast cell culture; exhibiting cell aggregation, rounding, and cell detachments. Collectively, only 70 serum samples were positive for anti‐REV antibodies with seroprevalence rates of 35% based on the ELISA test. The histopathological observation demonstrated lymphoreticular tumors in the liver, spleen, and other examined organs. The immunohistochemical staining method confirmed the REV-positive signals in all examined organs (liver, kidney, spleen, bursa, ovaries) except for the heart. The PCR assay of the LTR gene assessed 370 base pairs with only 5 positive samples with a percentage of 16.6%. Three positive samples were further sequenced and submitted to the Genbank under accession numbers (PP763709, PP763710, PP763711). Phylogenetic analysis of the REV-LTR gene showed that our three isolates (Sharquia-1-REV, Ismilia-2-REV, Mansoura-3-REV) are REV subtype III which predominantly circulated in breeders in Egypt. These three isolates are highest similar to American, Chinese, and Taiwanese REV reference strains, and other Egyptian strains with nucleotide identity percentages of 100%, 99%, and 99%; respectively, and on the amino acid identity level were with (99–100%), (98%, 99%), (99%, 100%); respectively.

Conclusions

This study established that REV infection was extensively distributed in the breeders and became one of the causes of the clinical outbreaks of tumors, raising awareness of REV as the causative agent of avian oncogenic disease in Egypt.
Greenness assessment of a molecularly imprinted polymeric sensor based on a bio-inspired polymer
Authors: Adawy Hamees A. , Hegazy Maha A. , Saad Samah S. , Bekhet Amr M. , Boltia Shereen A.
Published: October 2024

Methyldopa, a synthesized dopamine substitute with phenolic, amine, and carboxylic groups, was used to create a selective molecular imprinted polymer (MIP) for detecting formoterol fumarate dihydrate (FFD), a long-acting beta2-agonist for asthma and COPD. The bio-inspired polymer (MD) was electro-grafted onto a pencil graphite electrode (PGE) using cyclic voltammetry in a phosphate buffer (pH 6.5). An indirect method involving a redox probe (ferrocyanide/ferricyanide) and differential pulse voltammetry measured FFD binding to the MIP’s 3D cavities. The sensor showed a linear response range from 1 × 10⁻⁹ M to 2 × 10⁻¹⁰ M, with a detection limit of 1.7 × 10⁻¹¹ M. The polymethyldopa (PMD) and FFD interaction was assessed by UV spectroscopy, and the method was validated per ICH guidelines. Green analytical approaches, including RGB and GAPI, were also implemented. The goal was to use advances in molecularly imprinted polymers to develop a more precise and selective electrochemical sensor for FFD quantification.
Aberrations in medically certified sick leave and primary healthcare consultations in Norway in 2023 compared to pre-COVID-19-pandemic trends
Authors: White Richard Aubrey , Zhang Chi , Valcarcel Salamanca Beatriz , Angelsen Aslaug , Zakiudin Dinastry Pramadita , Andries Aristomo , Kabashi Saranda , Moberg Lene Lehmann
Published: October 2024

Background

Since 2022, Norway has employed a vaccine-only COVID-19 strategy. Primary healthcare in Norway uses International Classification of Primary Care version 2 (ICPC-2) codes. This study aims to systematically compare medically certified sick leave and primary healthcare consultations in 2023 with the pre-pandemic 2010–2019 trends, and subsequently estimate the magnitude of these changes.

Methods

For the respective outcomes of (A) working person-years lost to medically certified sick leave (WYLSL) and (B) number of primary healthcare consultations, 556 and 85 ICPC-2 code combinations were extracted from the Norwegian Labour and Welfare Administration’s sick leave registry and the Norwegian Syndromic Surveillance System. For each ICPC-2 code combination, a Bayesian linear regression was performed using data between 2010 and 2019 to estimate an expected baseline for 2023, which was then used to calculate the deviation from the pre-pandemic trend. A false discovery rate of 5% was used to account for multiple testing.

Results

All years from 2020 to 2023 had excess WYLSL, corresponding to 14,491 (90% PI: 8,935 to 20,016) in 2020, 12,911 (90% PI: 5,916 to 19,996) in 2021, 21,263 (90% PI: 12,627 to 29,864) in 2022, and 24,466 (90% PI: 14,023 to 34,705) in 2023. This corresponded to an economic loss of approximately 1.5 billion USD in 2023. Excess WYLSL due to A* (General and unspecified) increased from 2020 to 2023, with an estimated excess of 4,136 WYLSL in 2023 (69% higher than expected). More than half of this increase was explained by A04 (Weakness/tiredness general), whose excess WYLSL in 2023 were estimated at 2,640 (80% higher than expected). The excess in A04 (Weakness/tiredness general) corresponded to an economic loss of 161 million USD and accounted for 11% of the total excess WYLSL in 2023. The excess WYLSL in R* (Respiratory) in 2023 was 3,408, which correspond to an economic loss of 207 million USD and accounted for 14% of the total excess in 2023.

Conclusions

Significant excesses in working person-years lost to medically certified sick leave and primary healthcare consultations in 2023. A sizable proportion of the excesses were due to diseases/symptoms associated with acute and post-acute sequelae of COVID-19.
Fixing active sand dune by native grasses in the desert of Northwest China
Authors: Zhong Linfei , Feng Xiangyan , Zhao Wenzhi
Published: October 2024

Background

Desertification is the most severe environmental problem in arid and semi-arid regions and has caused great economic loss every year. However, artificial sand fixation barriers function on sand fixation for only 10–20 years. Searching for a native species with long-term sand fixation effect and strong environmental adaptive capacity, and low water consumption is needed. In this study, we investigated the environmental adaption and sand fixation effect of a grass from Poaceae family (Psammochloa villosa) that is indigenous to the desert of Northwest China.

Results

The results showed that P. villosa has a streamlined leaf form, strong mechanical strength, and flexibility to adapt to wind. Leaf curling of P. villosa under drought decreased water loss rate through decreased evaporation area to adapt to drought. Significant negative relationship between adventitious root length and horizontal root burial depth indicates that adventitious roots help P. villosa absorb water and nutrients from soil under shallow sand burial condition, which enables P. villosa to adapt to different sand burial conditions. P. villosa fixed sand dunes through the distribution of the population at the top of the dune and the vertical relationship between the direction of windblown sand and the direction of growth of P. villosa, which stopped the expansion of the dune.

Conclusions

Growth characteristics of wind and drought tolerant leaf traits and adventitious roots under sand burial indicate that P. villosa is well adapted to dry sandy desert conditions and burial by sand. The distribution of the P. villosa population on the sand dune is a “brake” on its expansion. These findings provide new insight for active sand dune fixation and desertification control using native grass in the desertified regions.
Impacts of micro and nanoplastics on human health
Authors: Jayavel Sridhar , Govindaraju Boopalakrishnan , Michael Johni Rexliene , Viswanathan Balaji
Published: October 2024

Background

Plastics are the most flexible products developed with a wide range of applications. They have been incorporated into almost every aspect of daily life due to their strength and low weight. However, widespread use and inadequate waste management have resulted in the accumulation of tiny plastic particles throughout the environment.

Main text

Microplastics are found in oceans, rivers, sediments, sewers, soil, and agricultural products, even in table salts. Human beings are affected by microplastics through food ingestion and inhalation. Incorporated microplastics may accrue within the body and affect gastrointestinal, immune, endocrine, brain, and respiratory systems. It also interferes with the functions of major organs and causes chromosomal abnormalities.

Conclusion

Addressing the issue of micro and nanoplastics requires interdisciplinary research, sustainable solutions, and improved waste management systems. The main focus of this review is to cover the harmful effects and impact of microplastics on human health and stress the need for combating strategies.
How to Queer the Domestic
Authors: Gutterman Lauren Jae , Manalansan Martin F. , Vider Stephen
Published: October 2024

This essay serves as the introduction to a special issue of GLQ, “Queering the Domestic.” The essay both summarizes the interventions of the essays in this special issue and introduces readers to the concept of queer domesticity. In particular, the essay highlights the different ways the home might be queered and the various meanings domestic spaces have held for LGBTQ+ people.
Queer Limitrophic Dwelling
Authors: Avalos Miguel A.
Published: October 2024

Based on twenty-one months of ethnography and interviews with transborder commuters in the San Diego-Tijuana border region, this article develops the notion of “queer limitrophic dwelling.” Building on queer, feminist, and transnational scholarship on home and dwelling, the article demonstrates how transborder commuters negotiate white Euro-American renditions of home and domesticity that emphasize privacy and fixity as the “proper” ideal vis-à-vis the home. It argues that transborder commuters enact several life-making or queer tactics — practices not necessarily enacted by LGBTQ+ subjects — that spatially decentralize their homes in Tijuana by harnessing transborder kinships and by making queer use of spaces and objects at the San Ysidro port of entry and across San Diego. In doing so, transborder commuters’ domestic labor practices produce ephemeral mobile dwellings when needed, allowing them to navigate multiple temporalities and survive normalized conditions of displacement occasioned by US land ports of entry and racial capitalism. Importantly, queer limitrophic dwelling highlights the US-Mexico borderland's capabilities to nourish and maintain life while also being a product of US settler colonialism engendered through historic and ongoing border violence and exclusion.
“Stop AIDS Evictions!”
Authors: Schreiner Maggie
Published: October 2024

The early AIDS epidemic in New York City revealed the intersection of two long-term crises impacting gay and lesbian tenants in the city: a critical lack of affordable housing and homophobic discrimination in private and public housing provision. People with AIDS and their family members faced tenant harassment, eviction, and structural homophobia in New York State's rent regulations. This article's microhistory of the eviction of Michael Brown, a rent-regulated tenant in New York City's Chelsea neighborhood, highlights how activists brought knowledge acquired in the traditional tenant movement into new gay and lesbian organizations. This collaboration was a result of Chelsea's history as a center of both militant tenant organizing and neighborhood-based gay and lesbian activism. In Chelsea, gay and lesbian residents joined the housing movement as low-income tenants, while also participating in neighborhood activism reflecting their concerns as gay and lesbian residents. Michael Brown's eviction case brought these two local organizing traditions into direct collaboration. This article builds on scholarship revealing the political agency of tenants and recent literature on housing and care during the AIDS epidemic by situating gay and lesbian advocacy for housing during the early AIDS crisis within a long trajectory of New York City tenant activism.
Origin and Course Cavernous Internal Carotid Artery Branches from the Endoscopic Endonasal Perspective: Cadaveric Study and Analysis Clinical Implications
Authors: Agosti Edoardo , Alexander A. Yohan , Dang Danielle D. , Leonel Luciano C. P. C. , Zeppieri Marco , Pinheiro-Neto Carlos D. , Peris-Celda Maria
Published: October 2024

BACKGROUND AND OBJECTIVE:

Endoscopic endonasal approaches to treat cavernous sinus lesions require detailed knowledge of the origin, course, and anatomic variations of the branches of the cavernous internal carotid artery (cICA) because inadvertent avulsion can cause intraoperative ICA injury. We aim to study the origin and course of the branches of the cICA from an endoscopic endonasal perspective and relate these branches to surgically relevant anatomic references.

METHODS:

Sixty sides of 30 formalin-fixed specimens were dissected to identify the origin and course of cICA branches, including the inferolateral trunk (ILT), the meningohypophyseal trunk (MHT), anterior and inferior McConnell's capsular arteries (MCAs), and the superolateral trunk (SLT).

RESULTS:

The ILT and MHT were bilaterally in all specimens, whereas the anterior and inferior MCAs were identified in 28% and 25% of dissected sides, respectively. The SLT was only found in 3% of sides dissected. The MHT was the most proximal branch of the cICA, and its origin was an average of 8.9 mm anterior to the foramen lacerum and 3.8 mm superior to the sellar floor. The ILT was the second most proximal branch of the cICA, which originated 6.4 mm from the MHT on average. The anterior and inferior MCAs were present in 28% and 25% of specimens, respectively. The SLT, when present, was the second most proximal branch of the cICA, which originated at a mean height of 2.7 mm from the sellar floor. Overall, complete ILT and MHT were identified in 68% and 77% of cases, respectively.

CONCLUSION:

The MHT and ILT are constant branches of the cICA, with the MHT originating from the medial cICA posterior bend 4 mm superior to the sellar floor and 9 mm anterior to the foramen lacerum, whereas the ILT arises from the lateral horizontal cICA, 2.3 mm superior to the sellar floor and 6 mm anterior to the MHT.
Paradoxical Leadership and Employee Proactive Work Behavior: Exploring the Mediating Role of Perceived Psychological Contract Fulfillment.
Authors: Elshaer Ibrahim , Azazz Alaa M. S. , Abdulaziz Tamer Ahmed , Fayyad Sameh
Published: October 2024

Background This study delves into the intricate interplay among paradoxical leadership (PL), employees’ proactive work behaviour (PAB), and perceived psychological contract fulfilment (PPCF). PL, characterized by its simultaneous emphasis on apparently contradictory behaviours, has garnered attention due to its potential to foster innovation, adaptability, and creativity. The study’s main objective is to thoroughly explore the complexities of PL, its influence on PAB, and whether the PPCF serves as a mediator. Methods A survey was distributed to 338 hotel and travel agency employees to gather data. The data was analysed using structural equation modelling through a SmartPLS program. Results The results reveal a positive correlation between PL and PAB. Additionally, PPCF partially mediates this relationship, indicating its vital role in exploring the positive impact of PL on boosting proactive behaviours. Conclusions This research brings forth meaningful contributions to both theoretical and practical dimensions. Theoretically, it enhances our comprehension of how PL manifests in the distinctive landscape of the hospitality and tourism domain, substantiating its potential to drive proactive behaviours among employees. The mediation of PPCF enriches our grasp of the underlying mechanisms, accentuating the significance of maintaining harmonized and consistent leadership practices. From a practical vantage point, these findings offer valuable insights for hospitality and tourism establishments aspiring to optimize their leadership strategies for cultivating proactive work behaviour among their workforces.
Zarządzanie talentami w przedsiębiorstwach chemicznych w kontekście Przemysłu 4.0
Authors: Sudolska Agata , Łapińska Justyna , Górka Joanna , Chodorek Monika , Zinecker Marek
Published: October 2024

Talent management is a concept that covers activities falling within the area of personnel policy related to the creation of special development programmes for employees with the greatest development potential. Chemical companies, just like many others, must develop their competencies in acquiring, developing and retaining talented employees, thanks to which they will be able to constantly achieve progress and compete on a global scale. In response to this need, this study focuses on the issue of talent management in chemical companies in the context of the development of Industry 4.0. The main aim of the work is to assess the level of talent management in Polish chemical industry enterprises and to identify the relationships between the individual components of this process.
Ocena wybranych markerów obrotu kostnego u chorych z chorobą zwyrodnieniową odcinka lędźwiowego kręgosłupa
Authors: Liczner Grzegorz
Published: October 2024

Degenerative spine disease is one of the most common diseases of the human musculoskeletal system. In light of research from recent years, it isDegenerative spine disease is one of the most common diseases of the human musculoskeletal system. In light of research from recent years, it is the main reason for medical advice. In clinical observation, it is a polyarticular degeneration that affects at least one section of the spine (cervical, thoracic, lumbar or sacral). Currently, it is believed that degenerative spine disease is the result of exposure to many pathological factors. Each of them is characterised by different intensity and duration. Unfortunately, they are only partially under our control.
Mittelalterliche Doppelbestattungen auf den Gräberfeldern Polens
Authors: Bojarski Jacek
Published: October 2024

Gemeinsame Gräber einer Frau und eines Mannes – die als Ehegatten gelten – sind unter den Bestattungen  frühmittelalterlicher Slawen nicht oft zu finden. Ist es anzunehmen, dass es in „barbarischen“ Gemeinschaften einen Brauch gab, nach dem ein verstorbener Mann auf  dem Weg ins Jenseits von seiner Frau oder – alternativ –  einer auserwählten Frau begleitet werden sollte? Wenn  ja, war diese „Begleitung“ freiwillig oder erzwungen? Als Beispiel für die Überlegungen zu diesem Thema dienen frühmittelalterliche Doppelbestattungen aus dem  heutigen Polen.Übersetzt von Małgorzata Derecka
“Like a phoenix from the ashes”
Authors: Ożóg Kazimierz S.
Published: October 2024

The article presents selected forms of material commemoration of the raid on Würzburg on March 16, 1945, and the efforts related to the subsequent reconstruction. Models, paintings, monuments, small architectural and sculptural forms, as well as the furnishings and decorations of churches preserve the memory of the event that changed the city and its form. This text is a sketch and at the same time an element of broader research conducted by the author on the forms of storing memory in cities destroyed during World War II.
Enhancing Athletic Recovery: Scar Treatment Using Microneedling, Dermal Fillers, and Lasers
Authors: Kuźma Krzysztof , Jakubowska Eliza , Hoppe-Mitera Ewa , Sionek Irena , Pakuła Anita , Ślemp Julia , Bierć Karolina , Grochowska Marcelina , Kisiel-Cybula Ewelina
Published: October 2024

Introduction and purpose: Scars represent a prevalent skin irregularity encountered by a significant portion of the population. Beyond merely impacting physical appearance, they can also contribute to the onset of depression and anxiety disorders, which may hinder athletic recovery. The treatment landscape for scars is diverse, spanning non-invasive to invasive procedures. This literature review endeavors to explore scar management, particularly focusing on methodologies involving microneedling, dermal fillers, and laser interventions. By examining these innovative approaches, we aim to provide insights into their efficacy and implications for clinical practice, with a particular emphasis on facilitating a faster return to sport and optimal athletic performance.
Material and methods: The literature was conducted using "Pub Med" and "Google Scholar"
databases with the keywords „scars”, „microneedling”, „dermal fillers”, „lasers”
Brief description of the state of knowledge: Scar therapy using microneedling, dermal fillers, and lasers has shown high effectiveness and significantly improves the lives of patients undergoing treatment.
Results and conclusions: Treating scars using microneedling, dermal fillers, and laser therapy has led to significant enhancements in both physical functioning and psychological well-being among patients with visible scars. These procedures exert their efficacy by promoting collagen synthesis and facilitating skin regeneration, thereby ameliorating skin redness, erythema, and scar tissue formation. However, it's important to note that the effectiveness of these interventions varies depending on factors such as the type and depth of the scar, as well as the age of the patient.
Etyczne aspekty koncepcji odosobnienia Mistrza Eckharta
Authors: Mickiewicz Adriana
Published: October 2024

Artykuł omawia kategorię odosobnienia (Gelassenheit, Abgeschiedenheit) Mistrza Eckharta jako propozycję etyczną. W pierwszej części artykułu autorka omawia kwestie metodologiczne oraz translatorskie. Następnie przedstawiony zostaje kontekst teologii apofatycznej, w którym Eckhart wprowadza pojęcie odosobnienia. Trzecia i czwarta część została poświęcona ideałowi ubóstwa oraz teorii cnoty. Autorka pokazuje w jaki sposób pojęcie odosobnienia może być odczytywane jako przede wszystkim postulat z zakresu filozofii moralnej.
Nowenna na pierwsze polskie wydanie Nowej Justyny Markiza de Sade
Authors: Kruszelnicki Wojciech
Published: October 2024

Artykuł ten wykorzystuje okazję, jaką jest bezprecedensowe wydanie w Polsce Nowej Justyny – jednego z najbardziej niesławnych i skandalicznych dzieł Markiza de Sade (Kraków: Eperons, 2022, przeł. Krzysztof Matuszewski, tom 1-6) – aby zarysować szczególną historię towarzyszącą publikacji tego dzieła, a także by przypomnieć ewentualnym czytelnikom o jego znaczeniu literackim i filozoficznym w opozycji do popularnych aczkolwiek trywialnych twierdzeń, że twórczość Sade’a to nic więcej jak pornografia. Konsekwentny rozwój  myśli sadycznej ukazuje filozoficzną odyseję ludzkiego poszukiwania suwerenności. Ma ona swój początek w oświeceniowej negacji Boga, lecz nie zatrzymuje się na niej. W pełni zautonomizowany rozum wchodzi w sojusz z Naturą, lecz jego również musi zakwestionować, tak jak musi zanegować Innego oraz samo Ego, by ostatecznie osiągnąć stanowisko nihilistycznego immoralizmu przejawiającego się apatycznym ponawianiem zbrodni.
Pytanie o metodę i etykę we wczesnej filozofii Martina Heideggera
Authors: Waśko Mateusz
Published: October 2024

Celem tego artykułu jest analiza powiązań jakie zachodzą pomiędzy fenomenami metodyczności i etyczności we wczesnej filozofii Martina Heideggera. Nie pojmuje się tu ani metody jako procedury badawczej prowadzącej do określonych rezultatów, ani etyki jako odrębnej dyscypliny filozoficznej posiadająca własne pole przedmiotowe. Chodzi o dwa wymiary bycia, które wzajemnie się implikują. Na początku badana jest fenomenologia jako sposób pytania o bycie, a następnie zostaje wydobyty metodyczny sens postępowania, które Heidegger określa mianem formalnego wskazywania. W rezultacie metodyczność zostaje odsłonięta jako droga prowadząca do bycia jako źródła sensu, droga, którą zapewnia samo to bycie. W dalszej kolejności analizowany jest fenomen filozofowania, który Heidegger interpretuje jako wyraźne transcendowanie. Transcendowanie to ostatecznie okazuje się wolnością, której fundamentalny charakter stanowi pozwolić-być, kładące jednocześnie fundament pod odpowiedzialność. Odpowiedzialność zaś jest odpowiedzią udzielaną na wezwanie bycia i przyjmuje postać (zobo)wiązania Dasein wobec bytu, któremu pozwoliło ono być. Etyczność odsłania się tym samym jako domaganie się takiej odpowiedzi na wezwanie bycia, która sprosta ciężarowi jego przesłania. W tym miejscu na jaw wychodzi spotkanie etyczności z metodycznością – ta ostatnia jest drogą do otwartości bycia zapewnioną przez samą tę otwartość, by postulat etyczności mógł zostać spełniony. Oznacza to, że etyczność domaga się metodyczności, a metodyczność (a wraz z nią filozofowanie) niesie ze sobą konsekwencje etyczne dla rozumienia bycia i bytu.
Słowa kluczowe: Heidegger, fenomenologia, metoda, etyka, wolność, odpowiedzialność
Some Remarks on the Development Potential of Ethnographic Museums in Poland
Authors: Wasilewska Joanna
Published: October 2024

The reflections presented in this text are based on over thirty years of experience, ten of which were spent as director of the Andrzej Wawrzyniak Asia and Pacific Museum in Warsaw. If a museum—nowadays called ethnographic—is to fulfil its mission of showcasing the richness of the world and the diversity of human thought and activity, it must continue to evolve. It should engage in extensive networks and partnerships, both formal and informal, to build trust between itself and its various stakeholders. Moreover, it must participate in public discussions and processes. Such a museum should be grounded in professionalism, courage, and respect. Museum professionals, in turn, must always set high standards for themselves, recognising that freedom and responsibility are two sides of the same coin.
I Cuaderno Cátedra RTVE-US. Conversaciones con Samuel Martín Mateos, director de La 2
Authors: García Gordillo María del Mar , Martínez García Ángeles
Published: October 2024

Este volumen inaugura la serie de Cuadernos de la Cátedra RTVE-US de Contenidos Culturales y Creatividad en el Sector Audiovisual y Digital, fruto de un convenio firmado entre Radio Televisión Española y la Universidad de Sevilla en junio de 2021. En octubre 2023 la Cátedra puso en funcionamiento un Seminario Permanente en el que profesores de distintas áreas de conocimiento conversan con profesionales del ente público para acercar su trabajo a los estudiantes de los títulos de Comunicación. Inaugura esta serie el diálogo mantenido entre Samuel Martín Mateos, director de La 2 durante casi una década, e Inmaculada Gordillo y Valerio Durán, profesores del Departamento de Comunicación Audiovisual y Publicidad de la Facultad de Comunicación de la Universidad de Sevilla, con quienes comparte sus más de cuarenta años de experiencia en RTVE.
Code and Data Repository for An Algorithm for Clustering with Confidence-Based Must-Link and Cannot-Link Constraints
Authors: Baumann Philipp , Hochbaum Dorit
Published: October 2024

The PCCC algorithm is a clustering method that incorporates both hard and soft must-link and cannot-link constraints.
Relato de Experiência: Visita Virtual como Ferramenta de Trabalho Durante a Pandemia de COVID-19
Authors: Beteille Irene Moura , De Oliveira Bruna Tadeusa Genaro Martins , Oliveira Ivanna
Published: October 2024

Este relato de experiência, de natureza qualitativa, decorre de nossa atuação, enquanto psicólogas, em um hospital da rede pública de saúde, voltado para o atendimento de pessoas acometidas pelo SARS-CoV, entre os anos 2020 e 2021. Nossa metodologia contará com estudos bibliográficos e apresentação casos clínicos, extraídos dos atendimentos realizados aos pacientes internados no hospital a partir de uma orientação psicanalítica. Em nossa abordagem, buscando mitigar a solidão em que muitos pacientes se viam inseridos, fizemos uso de tecnologias de informação e comunicação (TICs), o que permitiu o contato com os familiares que se encontravam impedidos de fazer visitas em função do alto risco de contágio da doença. Nosso objetivo com esse estudo é demonstrar que a atuação do psicólogo no contexto hospitalar não se limita à abordagem à beira leito. Também é possível viabilizar propostas mais amplas de atenção (nesse caso o uso das TICs), que colaborem com a política nacional de humanização (PNH), a partir de uma abordagem que leva em conta o contexto em que o paciente se vê inserido.
Narcisismo e o Processo de Morrer: A Potência do Encontro com o Outro
Authors: Nunes Morgana , Conti Luciane De
Published: October 2024

O presente artigo é parte de uma dissertação de mestrado que teve por objetivo compreender os possíveis desdobramentos narcísicos no sujeito com adoecimento crônico e em cuidados paliativos. Neste recorte, enlaçamos o conceito de narcisismo, a partir da perspectiva freudiana, ao processo de morte e morrer, principalmente no que diz respeito à potência do encontro com o outro. Tendo em vista que, na construção do pensamento psicanalítico, teoria e prática se intercruzam com frequência, e que é este "cruzamento" que permite avançar metapsicologicamente, valemos-nos dos relatos clínicos registrados pela primeira autora da sua experiência com pacientes em processo de terminalidade, no contexto dos cuidados paliativos. Para dar vida e sutileza à temática, também utilizamos a literatura e a poesia nessa construção. A análise desse material permitiu visualizar similaridades existentes entre os processos de constituição narcísica do bebê e o de reorganização narcísica daquele que morre, enfatizando o papel fundamental do outro no processo de morrer. Na terminalidade, esse outro pode desempenhar o papel de cuidado, amparo e nomeação desse novo corpo que se apresenta, ajudando o paciente na construção de novos sentidos para as experiências vividas e também para elaborar a trajetória para a morte.
Psicologia Histórico-Cultural da Arte: Intertextualidade e Relação Autor-obra-público
Authors: Rodrigues Júlia Loren dos Santos , Vecchia Marcelo Dalla , Marques Priscila Nascimento
Published: October 2024

A Psicologia Histórico-cultural da Arte, conforme elaborada por L. S. Vigotski, propõe um método explicativo para o estudo da vivência estética. Com o objetivo de ampliar o campo de investigação metodológica da psicologia da arte, partimos da interposição do conceito vigotskiano de vivência estética com o método de análise de unidades. Além disso, o fenômeno da intertextualidade e as dimensões histórico-culturais são tomados como elementos estruturantes para a investigação e interpretação do material empírico. Com base na premissa vigotskiana de que a vivência estética está articulada com a produção de novos sentidos, as contribuições de Antonio Candido são trazidas considerando o movimento estabelecido entre autor-obra-público, e incorporando as funções total, social e ideológica da literatura. Como contribuição metodológica, propomos que a vivência estética seja investigada, para além da destruição do conteúdo pela forma. Por fim, referendamos à obra como um sistema vivo, ao autor como uma função e ao leitor como um cocriador e, por isso, ativo no processo da vivência estética.
Ritual de cura para salvar um menino no ventre: mundos em guerra e a cosmovisão Jarawara em “O espírito aboni das coisas”, de Itamar Vieira Junior
Authors: Aguiar Rodrigues Adriana Cristina , Sousa da Silva Djorkaeff
Published: October 2024

No sudoeste do estado do Amazonas, entre os rios Juruá e Purus, habita uma etnia da família linguística Arawá quase totalmente invisibilizada entre a população brasileira: os Jarawara. Em sua cosmovisão, o mundo, organizado entre quatro espaços distintos (terra, água, abaixo da terra e céu), é tecido, de forma abstrata e concreta, pela coexistência de todos os seres: humanos, animais, plantas, árvores, espíritos (inamati) e bichos (yama). Esse mundo animista, na concepção Jarawara, apresenta-se constantemente como perigoso e em guerra, razão pela qual é preciso estabelecer laços com os espíritos (Maizza, 2009; 2012). É justamente da cultura desse povo que Itamar Vieira se alimenta em uma das narrativas que compõe o seu livro Doramar ou a Odisseia. Trata-se do conto “O espírito aboni das coisas”, no qual o leitor acompanha a saga do guerreiro Tokowisa pela floresta e pelas águas amazônicas, a fim de encontrar um objeto (abatosi) que, manipulado pelo xamã da aldeia, seja capaz de salvar sua esposa e seu filho (ainda no ventre) de um feitiço lançado pelo líder espiritual da aldeia rival, contra a qual estão em guerra. Tomando essa narrativa, nosso objetivo neste texto é articular uma análise Ecocrítica do conto, apropriando-nos de aspectos que caracterizam o seu enredo e suas personagens para tecermos correlações entre a cosmovisão Jarawara (as relações em um mundo constantemente perigoso, em guerra) e os modos como o escritor baiano elabora sua ficção.
Guerre, de Louis-Ferdinand Céline
Authors: Marques Amanda Fievet
Published: October 2024

Resenha do livro:
CÉLINE, Louis-Ferdinand. Guerre. Paris: Gallimard, 2022.