bluuebunny/crossref_metadata_2025 huggingface dataset:
Lacan, discurso, acontecimiento (reseña)
Authors: Sánchez Beltrán Carlos Andrés
Published: September 2020

Reseña:Parker, Ian y Pavón-Cuellar, David (Coord.). Lacan, discurso, acontecimiento. Nuevos análisis de la indeterminación textual. Ciudad de México: Universidad Michoacana de San Nicolás de Hidalgo - Plaza y Valdés Editores, 2013. 429 páginas.
The formation of a sociolinguistic style in translation
Authors: Nakamura Momoko
Published: September 2020

This paper illustrates the powerful role of translation in creating a sociolinguistic style. Through a quantitative survey of Japanese native speakers and a qualitative analysis of translated speech in an imported TV show and its Japanese parody, the study shows that Japanese translation practices have invented and preserved a widely recognised Japanese style associated with non-Japanese men. The study demonstrates that the style is linked with an image of non-Japanese young men characterised by cool informality; that it is marked by the use of linguistic features not commonly used among native speakers; and that it can be used to enregister a negative stereotype of non-Japanese masculinity, which serves to legitimate a polite, formal, Japanese normative masculinity. The findings suggest that translation is a process in which dominant ideologies of the target-language culture can be reinforced through the voices and bodies of nonnatives.
Contesting and advocating gender ideologies
Authors: Saito Junko
Published: September 2020

Previous scholars have identified sarariman (salaried men), who prioritise work over family, as the ideal of hegemonic masculinity in Japan. This study focuses on sarariman characters’ language use in the workplace as depicted in the 2015 Japanese TV drama Age Harassment. Employing the concepts of stance and hegemonic masculinities, the study demonstrates that, in this mediatised representation, the sarariman characters draw on diverse gender ideologies to display masculine identities. Using online commentary, the study also explores audience members’ responses to the drama’s depiction of masculinities. The study’s analysis of these two types of data suggests that despite increasing social acceptance of more diverse masculinities, the stereotypical sarariman remains to some extent the hegemonic ideal in contemporary Japan.
Language, gender and sexuality in Japanese popular media
Authors: Nakamura Momoko
Published: September 2020

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Rewriting Language: How Literary Texts Can Promote Inclusive Language Use by Christiane Luck (2020)
Authors: Lillian Donna L.
Published: September 2020

Rewriting Language: How Literary Texts Can Promote Inclusive Language Use
Christiane Luck (2020)
London: UCL Press, 204 pp.
“Não deixe o rock sair de você”: a configuração de identidade da Rádio Kiss FM no rádio expandido
Authors: Medeiros Rafael , Prata Nair , Lopez Debora Cristina
Published: September 2020

A construção e manutenção da identidade de uma emissora no rádio expandido não se restringe às características de programação, já que suas configurações transbordam do dial para outras plataformas, como as redes sociais digitais. Para verificar a configuração da identidade da Rádio Kiss FM enquanto emissora dedicada ao rock, o trabalho analisa o uso que ela faz das características culturais e associativas do gênero musical na programação em fluxo, no site a nas redes sociais on-line, recorrendo a referências estéticas e diretas próprias da cultura rock.
A irrupção da fake news no Brasil: uma cartografia da expressão
Authors: Vitorino Maíra Moraes , Renault David
Published: September 2020

Este estudo tem como objetivo construir uma cartografia da expressão fake news, em um recorte temporal que identificamos como sua irrupção no Brasil: entre os anos de 2017 e 2018. Anos em que o país vivenciou os períodos pré-eleitoral e eleitoral tendo a fake news como uma técnica aprimorada no conjunto de iniciativas utilizadas pelos candidatos e apoiadores para pautar o debate político. Para isso, damos visibilidade aos dados coletados nas duas instâncias observadas: a imprensa e o interesse de leitores na busca de notícias on-line. Chegamos ao contexto que um dos principais impulsionadores do acionamento da expressão é Jair Bolsonaro, atual presidente do Brasil que, desde a pré-campanha, utiliza a desqualificação do jornalismo profissional como uma estratégia discursiva para mobilização da opinião pública.
Women's issues∗
Authors: Keni Ravish , Mostacci Barbara , Kiteva‐Trenchevska Gordana , Licchetta Laura , Ignjatova Liljana , Thomas Sanjeev , Meador Kimford J.
Published: September 2020

Special considerations are required for women with epilepsy. These include issues such as catamenial exacerbation, concerns for contraception, teratogenesis (including both anatomical and neurodevelopmental effects), and other concerns for pregnancy complications such as increased seizures or adverse obstetric outcomes. In this manuscript, several cases are presented and discussed addressing some of the important issues in the management of women with epilepsy.
RTTBD‐like activity in association with hippocampal ictal discharges in patients with temporal lobe epilepsy
Authors: Sun Taixin , Liu Xi , Issa Naoum P. , Rose Sandra , Wu Shasha , Wang Qun , Martinez Raisa , Towle Vernon L. , Jr Douglas R. Nordli , Warnke Peter , Tao James X.
Published: September 2020

Aim. To determine clinical and intracranial EEG correlates of rhythmic temporal theta bursts of drowsiness (RTTBD) and assess its clinical significance in patients with temporal lobe epilepsy (TLE).

Methods. A retrospective review of simultaneous scalp and intracranial video‐EEG recordings from 28 patients with TLE was evaluated for epilepsy surgery. Scalp RTTBD patterns were identified and their clinical and intracranial EEG correlates were then determined on video‐EEG recording using depth and subdural electrodes.

Results. Thirty‐one RTTBD patterns on scalp EEG were observed in six (21%) of the 28 patients. Five (16%) of the RTTBD patterns occurred during wakefulness and 26 (84%) occurred during drowsiness and light sleep. The mean duration of RTTBD was 10 seconds (range: 3‐28 seconds). RTTDB consistently correlated with hippocampal ictal discharges and was time‐locked to the hippocampal seizures in which the ictal discharges evolved into rhythmic theta frequency (4‐7‐Hz) range. Ictal automatisms were observed during five (16%) RTTBD patterns, while cognitive impairment was observed in four (13%) of the 31 RTTBD patterns.

Conclusion. Our findings show that scalp EEG correlates of hippocampal ictal discharges can resemble RTTBD and may be associated with ictal symptoms and cognitive impairment, indicating that RTTBD may rarely be an ictal EEG pattern in patients with TLE.
Changes in serum perampanel concentration profile after discontinuation of carbamazepine
Authors: Murugesu Sumitha , Okayama Kiminobu , Yamamoto Yoshiaki , Terada Kiyohito , Takahashi Yukitoshi
Published: September 2020

Aim. To evaluate changes in the pharmacokinetics of perampanel after discontinuation of carbamazepine.

Methods. We enrolled 13 patients receiving perampanel who discontinued carbamazepine therapy between June 2016 and December 2018. Data on serum concentrations were obtained from the therapeutic drug monitoring database of the National Epilepsy Center (Shizuoka, Japan). To compare the pharmacokinetics of perampanel before and after discontinuation of carbamazepine, we determined the concentration/dose (CD) ratio of perampanel (serum level [ng/mL] divided by the dose [mg/kg]). The follow‐up period was set to eight weeks following the discontinuation of carbamazepine therapy.

Results. The mean baseline CD ratio of perampanel was 1,247 ng/mL/mg/kg which increased markedly over time after discontinuation of carbamazepine, with a mean CD ratio at Weeks 1‐2, Weeks 3‐4, and Weeks 5‐8 of 2,683, 3,914, and 4,220, respectively. At eight weeks, the mean CD ratio of perampanel had increased by 276%. Eleven patients developed adverse events, including dizziness, somnolence, irritability, and ataxia. Five of these 11 patients required perampanel dose reduction within eight weeks after discontinuation of carbamazepine. Two patients achieved seizure‐free status at Weeks 5‐8.

Conclusion. The serum perampanel concentration began to increase from one week after discontinuation of carbamazepine, and continued to rise for eight weeks. Based on these findings, we recommend frequent monitoring of serum perampanel concentration for at least eight weeks after stopping carbamazepine therapy. Monitoring is required as a guide for dose adjustment in order to achieve a safe and effective therapeutic dose of perampanel.
How to diagnose and classify idiopathic (genetic) generalized epilepsies
Authors: Elmali Ayse Deniz , Auvin Stéphane , Bast Thomas , Rubboli Guido , Koutroumanidis Michalis
Published: September 2020

Idiopathic or genetic generalized epilepsies (IGE) constitute an electroclinically well‐defined group that accounts for almost one third of all people with epilepsy. They consist of four well‐established syndromes and some other rarer phenotypes. The main four IGEs are juvenile myoclonic epilepsy, childhood absence epilepsy, juvenile absence epilepsy and IGE with generalized tonic‐clonic seizures alone. There are three main seizure types in IGE, namely generalized tonic‐clonic seizures, typical absences and myoclonic seizures, occurring either alone or in any combination. Diagnosing IGEs requires a multidimensional approach. The diagnostic process begins with a thorough medical history with a specific focus on seizure types, age at onset, timing and triggers. Comorbidities and family history should be questioned comprehensively. The EEG can provide valuable information for the diagnosis, including specific IGE syndromes, and therefore contribute to their optimal pharmacological treatment and management.
Topological indexes and community structure for urban mobility networks: variations in a typical day v1
Authors: Domingues Lamosa Jessica , R Tomás Lívia , G. Quiles Marcos , R. Londe Luciana , B L Santos Leonardo
Published: September 2020

This work fo-cused in the problem of Urban mobility, which in an unplanned urban growth sce-nario might generate negative impacts, like traffic jams, air pollution and infras-tructure flaws. Based on real data for the city of São José dos Campos, the mobil-ity of a typical day was represented. These data consist of an Origin-Destinationsurvey: the city was divided into 55 traffic zones and more than 20 thousand peo-ple were asked about the time of departure and arrival of each trip. The devel-opment was divided in 3 steps, pre-processing, processing and post-processing.In preprocessing, an origin destination graph was generated with a 3-dimensionmatrix representation, in language C++, in which each vertex represents a traf-fic zone and the edges are weighted by the flux of people, with 24 time variations,one for each hour of the day. In the processing, in C, the igraph library was usedto calculate the topological properties such as degree (number of connections),clustering coefficient (neighbors redundancy) and diameter (longest distance) ofa network of mobility over a typical day and we also applied the textit walktrapalgorithm for community detection. In the post-processing, using the concept of(geo) graphs, graphs represented with geolocation, the GeoCNet was developed. Itis a tool that allows the creation of a textit shapefile with the topological prop-erties of the graph.
Coronavirus Lateral Flow Assay (LFA) sample preparation protocol v1
Authors: he peijun
Published: September 2020

Coronavirus Lateral Flow Assay (LFA) sample preparation protocol
Highfield Diagnostics COVID19 LFA Protocol v1
Authors: he peijun
Published: September 2020

Highfield Diagnositc`s has developed a COVID-19 rapid diagnostic test (RDT), which is a lateral flow immunochromatographic assay (LFA), that detects nucleoproteinin nasal swab specimens.The test provides a simple colorimetric readout of results in less than 30 minutes (including sample preparation time) at a cost of <$5 per test, with no special reader or additional equipment. This scalable and accessible solution puts simple and frequent testing capacity, without the need for skilled personnel, into the hands of billions across the world.
ELISA for quantification of granulocyte macrophage-colony stimulating factor (GM-CSF) in human serum or plasma. v1
Authors: A Justiz-Vaillant Angel , Ferrer-Cosme Belkis
Published: September 2020

Interleukins (IL) are a type of cytokine first thought to be expressed by leukocytes alone but have later been found to be produced by many other body cells. They play essential roles in the activation and differentiation of immune cells, as well as proliferation, maturation, migration, and adhesion. They also have pro-inflammatory and anti-inflammatory properties. The primary function of interleukins is, therefore, to modulate growth, differentiation, and activation during inflammatory and immune responses. Interleukins consist of a large group of proteins that can elicit many reactions in cells and tissues by binding to high-affinity receptors in cell surfaces. [1] The immunoregulatory cytokine IL-41 (also known as meteorin-like protein) is expressed at high levels in the synovium of patients with psoriatic arthritis (PsA).[2] Reference 1. Justiz Vaillant AA, Qurie A. Interleukin. In:StatPearls. Treasure Island (FL): StatPearls Publishing; June 12, 2019. 2.Onuora S. Novel cytokine, IL-41, linked with PsA.Nat Rev Rheumatol. 2019;15(11):636. doi:10.1038/s41584-019-0314-7
TÜRKİYE’DEKİ E-ÖĞRENME ORTAMLARINDA BULUT BİLİŞİM KONULU LİSANSÜSTÜ TEZLERİN BETİMSEL TARAMA YÖNTEMİYLE İNCELENMESİ
Authors: BALCI Birim
Published: September 2020

Bu çalışmada, e-öğrenme ortamlarında bulut bilişim konusunda Türkiye’deki mevcut durumun betimlenmesi ve bu sayede bu konuda çalışmayı planlayanlara bir temel oluşturmak amaçlanmıştır. Ölçütler belirlenerek, alanyazında betimsel tarama yapılmıştır. Betimsel tarama sonucunda, 169 teze ulaşılmış, e-öğrenme alanı ile ilgili olmayan 156 adet bulut bilişim konulu tez çalışmanın kapsamı dışında tutularak, çalışma ölçütleri karşılayan 13 tez ile yürütülmüştür. Ulaşılan çalışmalar, tamamlandığı yıl, anahtar kelimeler, enstitü ve tez türü, anabilim dalı, hedef kitle, araştırma deseni, veri analiz yöntemi, tercih edilen bulut ortamları, e-öğrenme ile ilişkisi açısından incelenmiştir. Bulgular frekans dağılımları halinde sunulmuştur. Analiz sonucunda çalışmaya dahil edilen tezlerin 2011-2018 yıllarında tamamlandıkları, yüksek lisans tezlerinin doktora tezlerine göre daha fazla olduğu, en fazla çalışmanın Bilgisayar/Bilişim Sistemleri Mühendisliği anabilim dallarına bağlı yürütüldüğü tespit edilmiştir. Tezlerin enstitülerinin ve konularının çeşitlilik içerdiği ve bunların ya tasarım/geliştirme ya da uygulama/inceleme çalışmaları olduğu görülmüştür. Hedef kitle olarak genelde üniversite öğrencilerinin seçilmesi, karma çalışmaların sayısının azlığı, daha çok nicel yaklaşıma yönelik tezlerin ağırlıkta olduğu öne çıkmaktadır. Bu çalışmada, incelenen tezlerin e-öğrenme ile ilişkisine değinilerek, konuyla ilgili Türkiye’deki akademik çalışmalarla ilgili mevcut durum ortaya konmaya çalışılmış ve alandaki yeni çalışmalara ışık tutabilmek adına bir adım atılması hedeflenmiştir.
UYARLANABİLİR MOTİVASYON STRATEJİLERİ KULLANMANIN ÖĞRENCİ MOTİVASYONU VE BAŞARISINA ETKİSİ
Authors: ERDOĞDU Funda
Published: September 2020

Araştırmanın amacı, uyarlanabilir motivasyon stratejileri kullanmanın öğrencilerin motivasyonlarına ve başarılarına etkisini incelemektir. Araştırma öntest-sontest kontrol gruplu deneysel (2x2 faktöriyel) desende gerçekleştirilmiştir. Araştırmanın bağımlı değişkenleri başarı ve motivasyon; bağımsız değişkenleri ise uyarlanabilir motivasyon stratejilerinin kullanıldığı ve kullanılmadığı ortamlardır. Deney grubunda bulunan öğrencilere sunulan motivasyon stratejileri bilişsel stil özellikleri dikkate alınarak uyarlanmıştır. Deneysel işlemler süresince her hafta ders sonunda öğrencilerin motivasyon ölçümü yapılmıştır. Sonraki hafta deney grubunda bulunan her bir öğrencinin motivasyon durumu dikkate alınarak gereksinim duyduğu motivasyon stratejisi/stratejileri belirlenmiş ve uygulanmıştır. Uyarlanabilir motivasyon stratejilerinin kullanıldığı ortamda öğrenen öğrencilerin deneysel işlem sonrasında motivasyon ve başarı puanlarının motivasyon stratejilerinin uyarlanmadan kullanıldığı gruba göre manidar düzeyde yüksek olduğu, deneysel işlem öncesinden sonrasına, iki grubun motivasyon puanlarındaki değişimlerin uyarlanabilir stratejiler kullanılan grup lehine manidar düzeyde yüksek olduğu, buna karşılık başarı puanları arasındaki farkın manidar olmadığı tespit edilmiştir. Bu araştırmada, uyarlanabilir motivasyon stratejileri kullanmanın öğrencilerin motivasyonunu artırmada etkili bir araç olduğu ancak başarılarını artırmada etkili olmadığı sonucuna ulaşılmıştır.
A clinico-histopathological spectrum of Prostatic lesions at a tertiary care teaching institute
Authors: Krishna Tadepalli
Published: September 2020

: Prostatic carcinoma is the second most common cause of cancer deaths in men and the incidence is increasing significantly in recent years, due to early screening measures. A study designed to identify the prostatic lesions spectrum as per histopathological classification.

: 50 prostatic lesion samples collected in 10% formalin were subjected to H and E stain and the mean AgNOR counts were calculated.

: Out of 50 specimens, 80% were benign and 20% belongs to malignancy. The mean age of patient’s benign and malignant lesions is 63.5 ± 9.2 years and 69.5 ± 8.5 years respectively (P=0.09). The most common clinical symptom of benign lesions was frequency in35 patients, followed by hesitancy and nocturia in 33 and 30 patients respectively. Serum PSA values above 10ng/ml were seen in 10 benign cases and 5 malignant cases (P=0.02). Out of 50 cases, 35 were BPH, 5 were non-specific granulomatous prostatitis, 8 prostatic adenocarcinoma, 1 case urothelial carcinoma and 1case with both prostatic adenocarcinoma and urothelial carcinoma were recorded. High grade PIN identified in 9 specimens and low grade PIN identified in 8 specimens. High grade PIN shows association with adenocarcinoma. Basal cell hyperplasia identified in 3 specimens. Tufting Pattern was observed in 2 specimens, flat Pattern observed in 4 specimens, and cribriform pattern observed in 1 specimen out of 9. Majority of patients diagnosed as conventional adenocarcinoma with a score of 9 (3 cases) followed by score of 8 (2 cases).

: BHP is the most common non neoplastic prostate lesion, and commonly encountered in age group of 60- 70 years. In the current scenario, histopathological analysis of prostate specimens plays crucial role in both diagnosis and management.
The Alfieri’s edge-to-edge technique for mitral valve repair: from a historical milestone of cardiac surgery to the origin of the transcatheter era
Authors: Belluschi Igor , Buzzatti Nicola , Castiglioni Alessandro , Alfieri Ottavio , De Bonis Michele
Published: September 2020

After 30 years since its introduction, the edge-to-edge technique has become one of the most popular and adopted worldwide for surgical repair of mitral regurgitation. The success of this procedure could possibly be explained by its unique simplicity and high level of reproducibility. Indeed, it possesses the ability of being very versatile and it has been used in a wide spectrum of mitral valve pathologies and lesions: from degenerative to functional disease, from posterior to anterior leaflet lesions, including commissural defects. The rapidity of this easy surgical gesture has also enhanced its application in minimally invasive approaches. Finally, it has become a true milestone for the era of transcatheter correction of mitral regurgitation. Here, we describe the history and evolution of this breakthrough in the world of cardiac surgery.
Biodynamic Model of the Seated Human Body under the Vertical Whole Body Vibration Exposure
Authors: Kumar Vikas Kumar , Saran V. H.
Published: September 2020

The seat-to-head transmissibility and apparent mass characteristics are measured for the seated human subjects exposed to vertical whole-body vibration in the 0.5-20 Hz frequency range at a vibration magnitude of 1.0 m/s2 rms. The experiments are conducted on test subjects seated in an upright posture. A biodynamic model has been developed for bio-mechanical parameters that are estimated on the basis of identified biodynamic responses. The parameters identification technique employs a genetic algorithm for the solution of the function comprising sum of squared magnitude and phase errors related with target values of seat-to-head transmissibility and apparent mass. The developed model presents the target values of magnitude associated with apparent mass and seat-to-head transmissibility. The natural frequencies of the model have been found at up to 5.0896 Hz. The model also presents the resonant frequencies calculated on the basis of both biodynamic response functions very close to that found for seated human body experimentally.
Coronavirus (Covid-19) Pandemic: Outbreak, Current Scenario, and Impact on Human Physiology in Pakistan
Authors: Jabeen Komal , Husnain Haider Muhammad Basit , Haider Zeshan , Ali Sultan , Hassan Ali , Khan Niazi Adnan
Published: September 2020

Coronavirus that is also known as COVID-19 disease is produced by SARSCoV-2. This causative agent is highly contagious and can cause potentially fatal pneumonia worldwide with serious public health concerns. In the beginning among infected individuals, most of them were those who were mainly shown to the wet animal market in a big city of China known as Wuhan. So, it was suggested that this was almost certainly the zoonotic source of COVID-19illness. The transitional source of origin and their mode of transmission to humans were not known obviously. Conversely, from human to human rapidly transformation have been confirmed generally. Currently, there is no availability of FDA approved clinically antiviral drugs and/or vaccines to be used against the COVID-19. Afterward, SARS-CoV and MERS-CoV, the occurrence of SARS-CoV-2 has been manifested as the third sketch of an enormously pathogenic coronavirus into human population globally. In this review, we provide a brief overview of the history of COVID-19 in Pakistan up-to 18th weeks after beginning, current situation, epidemiology, and its impact on the human population. Moreover, we focused on physiological variation during the incubation period, genome analysis of SARS-CoV2, supportive treatment approaches, and safety measures in the Pakistani population, which may be supportive for combating the risk of COVID-19 epidemic. We also reviewed the future approaches for the development of therapeutic interventions and vaccines to cope with the COVID-19 epidemic.
Searching Hit Potential Antimicrobials in Natural Compounds Space Against Biofilm Formation
Authors: Pestana Roberto , Leyva Jorge , Yosa Juvenal
Published: September 2020

Biofilms are communities of microorganisms that can colonize biotic and abiotic surfaces playing a significant role in the persistence of bacterial infection and antibiotic resistance. About 65% and 80% of microbial and chronic infections are produced by biofilm formation. The increase in infections by multi-resistant bacteria draws attention to the discovery of new drugs based on natural inhibitory molecules. The inhibition of diguanylate cyclases (DGCs), the enzyme implicated in the synthesis of the second messenger, cyclic diguanylate (c-di-GMP), involved the biofilm formation, represents a potential method for preventing the biofilm development. It has been extensively studied using PleD protein as a model of DGC for in silico studies as virtual screening and as a model for in vitro studies in biofilms formation. In the present study 224205 molecules from natural products database, ZINC15 has been evaluated through molecular docking and molecular dynamic simulation, our result suggests trans-Aconitic acid (TAA) as a possible starting point for hit-to-lead methodologies to obtain new molecules capable of inhibiting the PleD protein and hence blocking the biofilm formation.
Unique Existence of Globally Asymptotical Input-to-State Stability of Positive Stationary Solution for Impulsive Gilpin-Ayala Competition Model with Diffusion and Delayed Feedback under Dirichlet Zero Boundary Value
Authors: Rao Ruofeng
Published: September 2020

By partly generalizing the Lipschitz condition of existing results to the generalized Lipschitz one, the author utilizes a fixed point theorem, variational method and Lyapunov function method to derive the unique existence of globally asymptotical input-to-state stability of positive stationary solution for Gilpin-Ayala competition model with diffusion and delayed feedback under Dirichlet zero boundary value. Remarkably, it is the first paper to derive the unique existence of the stationary solution of reaction-diffusion Gilpin-Ayala competition model, which is globally asymptotical input-to-state stability. And numerical examples illuminate the effectiveness and feasibility of the proposed methods.
Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties and in vitro Bioaccessibility
Authors: Baenas Nieves , Ruales Jenny , Moreno Diego A. , Barrio Daniel Alejandro , Stinco Carla M. , Martínez-Cifuentes Gabriela , Meléndez-Martínez Antonio J. , García-Ruiz Almudena
Published: September 2020

Andean blueberries are wild berries grown and consumed in Ecuador which contain high values of bioactive compounds, mainly anthocyanins, with powerful antioxidant activity. The aim of this study was to evaluate the profile and contents of (poly)phenols and carotenoids in Andean blueberry by HPLC-DAD-MSn and determine a wide range of its biological activities. The antioxidant capacity of this fruit was evaluated in vitro by three different methods and in vivo using the zebrafish animal model, also the toxicity effect was determined by the zebrafish embryogenesis test. Besides, the antimicrobial activity and the capacity of Andean blueberry to produce hemagglutination in blood cells were evaluated. Finally, the bioaccessibility of (poly)phenols and related antioxidant capacity were determined in the different phases of an in vitro digestion. The global results indicated no toxicity of Andean blueberry, weakly bacteriostatic activity, and high contents of anthocyanins and antioxidant capacity, which were partially bioaccesible in vitro (~ 50 % at the final intestinal step), contributing to the knowledge of its health benefits for consumers and its potential use in the food and pharmaceutical industry as functional ingredient.
RECOGNITION OF FOSSIL NEBKHA DEPOSITS: CLUES FROM NEOICHNOLOGY AND SEDIMENTOLOGY
Authors: CARDONATTO M. CRISTINA , MELCHOR RICARDO NESTOR
Published: September 2020

This study includes the first neoichnologic characterization of the burrow systems of Tympanoctomys barrerae (Rodentia: Octodontidae) and also considers sedimentologic features of the modern nebkhas where they occur. Tympanoctomys is a South American solitary and fossorial rodent that has ecomorphofunctional adaptations for living in saline environments and constructs its burrow in nebkhas with halophyte shrubs. The purpose of this work is to identify the ichnologic signatures of T. barrerae burrow systems and to provide combined ichnologic-sedimentologic criteria for identification of Cenozoic nebkha deposits. Tympanoctomys barrerae burrow systems are subhorizontal, typically with ten or more entrances, two or three levels, closed circuits, average complexity of 48, average tortuosity of 3.25, and an average ratio of total chamber volume to total tunnel volume of 0.04. The size of the tunnels averages 85 mm in horizontal diameter and 64 mm in vertical diameter, and cross-section shape ranges from elliptical flattened to plano-convex with incipient bilobed floor. Surface ornamentation is typified by a coexistence of primary (sets of four claw traces forming an arcuate pattern produced during digging) and secondary (numerous arthropod burrows excavated from the burrow lumen) surface ornamentation. Nebkha deposits in upper Cenozoic sequences can be recognized by the combination of ichnologic and sedimentologic features: fossil burrows having the ichnologic features characteristic of T. barrerae burrow systems and presence of rhizoliths of shrubby plants occurring in well-sorted sandy deposits with low-angle crossbedding. These criteria can be potentially applied to fossil sequences dating back to the early Oligocene.
Foraminifera in the World Register of Marine Species (Worms) Taxonomic Database
Authors: Hayward Bruce W. , Coze François Le , Vandepitte Leen , Vanhoorne Bart
Published: September 2020

Most foraminiferal research is founded on sound taxonomy. To clearly communicate such research, similar species concepts and consistent use of names is desirable. As a contribution to this larger goal, the World Foraminifera Database (http://www.marinespecies.org/foraminifera) was set up in 2010 as a subset within the World Register of Marine Species (WoRMS). The purpose is to provide an authoritative, open-access inventory of all foraminiferal taxonomic names. The inventory is almost complete for both fossil and Recent foraminiferal taxa, containing 4932 generic and 55,884 species (including infraspecies) names. There are ∼61,000 genus-species combinations of which ∼54,600 are currently “accepted” species and infraspecies (with 9600 extant). Associated data includes 14,700 linked foraminiferal literature sources, ∼6600 images, and species-level links to many other databases and images, such as the Cushman Collection (Smithsonian Institution), American Museum of Natural History, Mikrotax (planktic foraminifera), GenBank, and Zootaxon. The WoRMS database is owned by the global taxonomic community and hosted and serviced by the Flanders Marine Institute (VLIZ), Belgium. We recommend that all researchers working with foraminifera both use and contribute to the World Foraminifera Database, as that will improve the accuracy of the database's content and save investigators many hours of searching elsewhere.
Application of an Improved Ant Colony Algorithm to Optimal Path Planning for Automatic Guided Vehicles
Authors: zhu weikang , liu jicheng
Published: September 2020

The path planning is the key technology of AGV path finding. This paper uses an improved ant colony algorithm to plan the path of an AGV. For avoiding the defects of traditional ant colony algorithm such as low smoothness of route and local optimal solution, the transition probability and pheromone update method are improved. Various actual turning situations are analyzed in the transition probability, the basis for defining the smoothing factor is provided by the Bezier curve, and a random selection operator is formed for updating local pheromone by extracting characteristic information of iterative process. The simulation results in different environments prove that the smoothing factor plays an important role in optimizing the smoothness of the path and the diversity of the constructed solutions, and the random selection operator is effective in solving the contradiction of the local optimal solution and in finding the optimal solution.
Student Satisfaction with Videoconferencing Teaching Quality During the COVID-19 Pandemic
Authors: Fatani Tarah
Published: September 2020

Background: The coronavirus disease 2019 pandemic prompted the pediatric department at King Abdulaziz University to continue students’ educational activities by offering courses online that utilized web video conferencing (WVC). Given the uncertainties of WVC educational quality and the challenge of shifting to an online environment, this study aimed to evaluate student satisfaction with the teaching quality of case-based discussion (CBD) sessions conducted through WVC.Methods: 162 undergraduate medical students in pediatrics completed the reduced Students’ Evaluation of Educational Quality (SEEQ) survey with a five-point Likert scale over 5 weeks. The WVC CBD sessions were facilitated by 50 faculty members. Results: 82% of respondents were highly satisfied with the WVC CBD session’s teaching quality. The majority agreed that the sessions were intellectually challenging, that the instructors were dynamic, and encouraged students to participate. No statistically significant correlation was found between student satisfaction and technical issues (r = 0.037, p = 0.003).Conclusions: WVC teaching had an overall positive outcome on student satisfaction, and teaching quality relied on teaching, cognitive, and social presence rather than technology. However, technology remains an important platform that supports teachers’ educational activities. Thus, implementing a blended pediatric course to augment future course delivery is optimal.
Crystallization pathways, morphologies and structural defects of α-MnO2 nanomaterial synthesized under annealed temperatures
Authors: Dinh Van-Phuc , Luu Anh Tuyen , Krzysztof Siemek , Kozlenko Denis , Khiem Le , Dang Nguyen Toan , Nguyen Van Tiep , Nguyen Le-Phuc , Tran Duy Tap , Phan Trong Phuc , Lo Thai Son , Anh Tuan Kiet Hoang , Dinh Thanh Khan , Luong Thuy Ngoc , Le Ngoc-Chung , Nguyen Ngoc-Tuan , Ho Thien-Hoang , Tran Dong Xuan , Nguyen Quang Hung
Published: September 2020

Manganese dioxide, in particular α-MnO2, is one of the advanced inorganic nanomaterials having wide applications in many areas. Hence, understanding the crystallization pathways, morphologies, and formation mechanism of defects in its structure is of particular importance, not only for fundamental science but also for practical applications. Herein, different physically and chemically based methods, such as Neutron Diffraction (ND), XRD, SEM, TPR- H2, TGA-DSC, FT-IR, Positron Annihilation Lifetime (PAL), Doppler Broadening (DB) of positron annihilation radiation, and Electron-Momentum Distribution (EMD) measurements combined with theoretical calculations, were utilized to systematically investigate the composition, structure, and morphology of α-MnO2 nanomaterial under different annealed temperatures. The investigated material was synthesized at room temperature using a facile chemical method with potassium permanganate (KMnO4) and ethanol (C2H5OH), prior to being treated by temperatures of 100 oC – 800 oC. Results demonstrated, for the first time, that the α-MnO2 nucleation can be formed even at room temperature and gradually developed to α-MnO2 nanorods at 600 oC. This novel finding, which cannot be explored by conventional XRD, was confirmed by ND analysis. In addition, PAL analysis combined with theoretical ab initio calculations indicated the existence of H+ ions in the tunnel [1x1] of α-MnO2. At the same time, DB and EMD measurements explored the presence of Mn and O vacancies in α-MnO2 crystals at low temperatures. Finally, the present study reported a remarkable finding that organic molecules may act as reactants as well as templates, which are entirely decomposed and disappeared at highly annealed temperatures.
A Bayesian Time-to-event Pharmacokinetic Model for Sequential Phase I Dose-escalation Trials with Multiple Schedules
Authors: Günhan Burak Kürsad , Weber Sebastian , Seroutou Abdelkader , Friede Tim
Published: September 2020

Background: Phase I dose-escalation trials constitute the first step in investigating the safety of potentially promising drugs in humans. Conventional methods for phase I dose-escalation trials are based on a single treatment schedule only. More recently, however, multiple schedules are more frequently investigated in the same trial.Methods: Here, we consider sequential phase I trials, where the trial proceeds with a new schedule (e.g. daily or weekly dosing) once the dose escalation with another schedule has been completed. The aim is to utilize the information from both the completed and the ongoing dose-escalation trial to inform decisions on the dose level for the next dose cohort. For this purpose, we adapted the time-to-event pharmacokinetics (TITE-PK) model, which were originally developed for simultaneous investigation of multiple schedules. TITE-PK integrates information from multiple schedules using a pharmacokinetics (PK) model. Results: In a simulation study, the developed appraoch is compared to the bridging continual reassessment method and the Bayesian logistic regression model using a meta-analytic-prior. TITE-PK results in better performance than comparators in terms of recommending acceptable dose and avoiding overly toxic doses for sequential phase I trials in most of the scenarios considered. Furthermore, better performance of TITE-PK is achieved while requiring similar number of patients in the simulated trials. For the scenarios involving one schedule, TITE-PK displays similar performance with alternatives in terms of acceptable dose recommendations. The R and Stan code for the implementation of an illustrative sequential phase I trial example is publicly available (https://github.com/gunhanb/TITEPK sequential).Conclusion: In sequential phase I dose-escalation trials, the use of all relevant information is of great importance. For these trials, the adapted TITE-PK which combines information using PK principles is recommended.
Choose to Move: A Health Promoting Physical Activity Intervention Can Also Enhance Social Connectedness
Authors: Franke Thea , Sims-Gould Joanie , Nettlefold Lindsay , Ottoni Callista , McKay Heather A.
Published: September 2020

Background: Despite the well-known health benefits of physical activity (PA), older adults are the least active citizens. Older adults are also at risk for loneliness. Given that lonely individuals are at risk for accelerated loss of physical functioning and health with age, PA interventions that aim to enhance social connectedness may decrease loneliness and increase long-term PA participation. The objectives of this mixed-method study are to: (1) evaluate whether an evidence-based PA intervention (Choose to Move; CTM) influenced PA and social connectedness differently among self-identified ‘lonely’ versus ‘not lonely’ older adults and (2) describe features of CTM that promote social connectedness.Methods: ﻿ Two community delivery partner organizations delivered 56 CTM programs in 26 urban locations across British Columbia. We collected survey data from participants (n=458 at baseline) at 0 (baseline), 3 (mid-intervention) and 6 (post-intervention) months. We conducted in depth interviews with a subset of older adults at baseline (n=43), mid-intervention (n=38) and post-intervention (n=19).Results: PA increased from baseline to 3 months in lonely and not lonely participants. PA decreased from 3-6 months in lonely participants; however, PA at 6 months remained above baseline levels in both groups. Loneliness decreased from baseline to 3 and 6 months in participants identifying as lonely at baseline. Features of CTM that influence social connectedness include: Activity coach characteristics/personality traits and approaches; opportunity to share information and experiences and learn from others; engagement with others who share similar/familiar experiences; increased opportunity for meaningful interaction; and accountability.Conclusion: PA interventions that focus on social connectedness, through group-based activities can improve the health of older adults by addressing both loneliness and PA. Building social connectedness within a PA intervention for older adults may support long term changes in PA behaviours.
Effect of alloying elements on thermal stability of Aluminium-Cerium based alloys
Authors: Saini Dheeraj Kumar , Gope Rahul , Mandal Animesh
Published: September 2020

The effect of alloying elements on thermal stability of five different near eutectic Al-Ce based alloys, i.e., Al-12Ce, Al-12Ce-4Si, Al-12Ce-0.4Mg, Al-12Ce-4Si-0.4Mg and Al-12Ce-4Si-0.4Mg-0.25Sr alloys were investigated. The alloys were heat treated at three different temperatures, i.e., 200 °C, 300 °C and 400 °C to establish the thermal stability. Binary Al-12Ce alloy consisting of α-Al and showed higher resistance to coarsening at all temperatures. Addition of Si decreases the thermal stability above 200 °C while combined addition of Si and Mg increases the thermal stability up to 300 °C. Addition of Sr to quaternary alloy was not beneficial to enhance the thermal stability.
Visual Short-term Memory Impairments in Presymptomatic Familial Alzheimer’s Disease: a Longitudinal Observational Study
Authors: Pavisic Ivanna M. , Nicholas Jennifer M. , Pertzov Yoni , O'Connor Antoinette , Liang Yuying , Collins Jessica D. , Lu Kirsty , Weston Philip S.J. , Ryan Natalie S. , Husain Masud , Crutch Sebastian J. , Fox Nick C.
Published: September 2020

Background: Cross-sectional studies in presymptomatic familial Alzheimer’s disease (FAD), have associated binding deficits with preclinical AD. How impairments in visual-short term memory (VSTM) relate to longitudinal change and proximity to expected symptom onset (EYO) is less characterized.Methods: Thirty-two FAD mutation carriers (23 presymptomatic; 9 symptomatic) carrying a mutation in either presenilin 1 or amyloid precursor protein genes and 67 healthy controls were included in an extension VSTM cross-sectional study. Forty-eight participants (23 presymptomatic carriers, 6 symptomatic and 19 healthy controls) who had at least two annual visits (median= 3), were included in the longitudinal study. Participants completed the “What was where?” relational binding task (which measures memory for object identification, localisation and object-location binding under different conditions of memory load and delay), neuropsychology assessments and genetic testing. Results: While cross-sectionally only symptomatic carriers (N=9) showed significant impairments in VSTM performance, longitudinally, presymptomatic carriers within 8.5 years of estimated symptom onset (mean=5.8 years ±SD [1.8], N=11) showed a faster rate of decline in localisation performance in long-delay conditions (4s) compared to controls: increase/year in localisation error was 6.9% greater in the high-memory load condition (p=0.008) and 7.0% greater for the low-memory load condition (p=0.043). Change in this metric preceded presymptomatic changes in traditional measures of verbal episodic memory. Symptomatic carriers had 15% faster reduction in identification performance per year compared to controls (p=0.036) and some evidence of faster increase in localisation error (6.5% increase/year; p=0.066). The earliest significant difference in VSTM performance between FAD mutation carriers (presymptomatic and symptomatic) and controls was in localisation performance, six years prior to estimated symptom onset (p=0.024). Conclusions: This longitudinal study of FAD, suggests changes in VSTM resolution, which measure precision and thus quality of recall of the memory presentation, may be sensitive markers for tracking and predicting cognitive decline in preclinical AD.
A Case of Ciprofloxacin-induced Acute Psychosis After Aortic Dissection Surgery
Authors: Song Guobao , Jiang Bo , Tan Shenglan , Li Feng
Published: September 2020

Ciprofloxacin is widely used in general infected population, including patients with aortic dissection. Ciprofloxacin-mediated neurotoxicity has been observed in few reports, and some studies found ciprofloxacin may increase the incidence of aortic dissection or aortic aneurysm rupture. We report here a case of ciprofloxacin-induced acute psychosis after Sun’s total arch replacement and cardiopulmonary resuscitation. Based on the published literature and FDA hypothesis, we suggest that ciprofloxacin should be used cautiously in patients after aortic dissection surgery in the risk of drug-induced psychosis and residual dilated aortic rupture.
Performance of ‘Chambourcin’ Winegrape on Nematode-resistant Rootstocks in Missouri
Authors: Thomas Andrew L. , Harris Jackie L. , Bergmeier Elijah A. , Striegler R. Keith
Published: September 2020

One of the most popular winegrapes (Vitis sp.) for red wine production in the midwestern United States is ‘Chambourcin’, a French-American hybrid. It is typically produced on own-rooted vines in the region, but the potential benefits of grafting it to improved rootstocks are becoming better-known. Nematodes present occasional serious winegrape production challenges in the midwestern United States, and are capable of transmitting pathogenic viruses. New rootstocks developed by University of California, Davis (UCD GRN series) are resistant to several species and races of nematodes, but have not been evaluated under midwestern U.S. production conditions. A study with ‘Chambourcin’ grafted to four of these new nematode-resistant rootstocks (‘UCD GRN-2’, ‘UCD GRN-3’, ‘UCD GRN-4’, and ‘UCD GRN-5’) and ‘Couderc 3309’, along with own-rooted vines was established in 2010 in southwest Missouri, and fruited in 2013–15. Three of the nematode-resistant rootstocks (GRN-2, 3, 4) performed as well as the standard ‘Couderc 3309’ and own-rooted vines, with yields among all rootstocks ranging from 10 to 13 kg/vine. The rootstock ‘UCD GRN-5’ generally performed poorly, however, manifested by low pruning weights and a high Ravaz index value (25) in 2013 that necessitated defruiting the vines in 2014. Fruit yields on ‘UCD GRN-5’ rootstocks were satisfactory in 2013 and 2015, but the vines eventually deteriorated, with 99% shootless nodes by 2017. Although more evaluations of these new rootstocks are needed in the midwestern United States, we conclude that ‘UCD GRN-2’, ‘UCD GRN-3’, and ‘UCD GRN-4’ show promise, whereas ‘UCD GRN-5’ does not appear suitable for growing conditions in southern Missouri.
New reduced-risk agricultural nematicides - rationale and review
Authors: Desaeger Johan , Wram Catherine , Zasada Inga
Published: September 2020

The last decade has seen a sharp increase in nematicide research in the agricultural industry. As a result, several new synthetic nematicides have become available to growers, and several more are expected in the near future. This new interest in nematicides is directly related to the growing demand for safer and more selective products, and the increasing regulatory pressure on many of the traditional nematicides. This has led to a ban of several widely used fumigant (e.g. methyl bromide) and non-fumigant (e.g. aldicarb) nematicides. The loss of traditional nematicides, combined with a lack of replacement products and awareness of the damage that nematodes can cause, has not only raised concern among growers, but has also created new opportunities for the crop protection industry. Nematicides have become a priority, and many companies are now allocating significant research dollars to discover new nematicides. The new nematicides are very different from previous products: (i) they are more selective, often only targeting nematodes, and (ii) they are less toxic, and safer to use. This review article describes these new developments by discussing the challenges that are associated with finding new nematicides, reviewing the nature, characteristics, and efficacy of new nematicides, and discussing the impact they could have on future nematode management.