bluuebunny/crossref_metadata_2025 huggingface dataset:
The polymyxin SPR206 remediates gram-negative infections in vivo
Authors: Fitzgerald Timothy , Castellanos Giovanna , Escatte Mariel , Hur Stephen , Majernik Stephanie , Wong Ting , Alamneh Yonas , Abu-Taleb Rania , Su Wanwen , Czintos Christine , Raynor Malik , Chattagul Supaksorn , Lanteri Charlotte A. , Pucci Michael , Getnet Derese , Swierczewski Brett , Kane Brian , Breton Yoann Le , Lister Troy , Zurawski Daniel
Published: July 2023

ESKAPEE pathogens (Enterococcus spp., Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter spp., and Escherichia coli), particularly the gram-negative species, are a problematic group of bacteria associated with nosocomial infections in susceptible patients. These infections are often further complicated by multidrug-resistant (MDR) strains and a lack of treatment options. While the pipeline of new antibiotics is nothing short of thin when it comes to gram-negative activity, one promising molecule is SPR206. SPR206 is a novel polymyxin antibiotic, a nonapeptide designed to overcome the nephrotoxicity associated with other members of this drug class. As intended, SPR206 was found to be safe with no severe adverse events in a Phase 1, single ascending dose/multiple ascending dose clinical trial. SPR206 has in vitro activity against almost all gram-negative species, and we confirmed this activity in minimal inhibitory concentration assays against unique diversity sets of bacterial isolates. Additionally, bactericidal activity was observed in time-kill assays, which is expected for polymyxins. Subsequently, we evaluated the safety and efficacy of SPR206 in three separate in vivo models: Galleria mellonella and two murine models, a pulmonary model and a wound model. In G. mellonella and in the mouse pulmonary model, SPR206 provided almost 100% survival in treated animal groups when compared to untreated control groups. With wound infection, SPR206 significantly reduced bacterial burden and decreased time to heal compared to untreated groups. With wound infection, SPR206 significantly reduced bacterial burden and decreased time to heal compared to untreated groups. These results suggest SPR206 is a potent antibiotic with MDR gram-negative activity that could have expanded clinical indications to include skin and soft tissue infection and hospital-acquired pneumonia.
Neuroprotective effects of Takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1
Authors: Hao Shuangying , Yuan Shuai , Liu Zhiqiang , Hou Baohua , Feng Sijie , Zhang Dingding
Published: July 2023

Transforming growth factor β-activated kinase 1 (TAK1) remarkably controls several signaling pathways regulating inflammation and apoptosis and represents an important target for pharmacologically treating traumatic brain injury (TBI). Takinib, a small molecule TAK1 inhibitor with potent anti-inflammatory activity, has shown promising activity in preclinical studies. The research dealt with evaluating the potential neuroprotective impact of takinib on a TBI rat model. A modified Feeney’s weight-drop model was employed to cause TBI in mature male Sprague-Dawley rats. One day after induction of TBI in the rats, they received an intracerebroventricular injection of takinib, and their histopathology and behavior were assessed. The results of this study demonstrated that takinib suppressed TBI progression in rats by decreasing TAK1, p-TAK1, nuclear p65, and ionized calcium-binding adaptor molecule 1 levels while upregulating the NF-κB inhibitor expression. Takinib significantly inhibited the production of two pro-inflammatory factors, tumor necrosis factor-α, and interleukin-1β. Furthermore, takinib remarkably upregulated the expression of tight junction proteins zonula occludens-1 and claudin-5 and reduced cerebral edema. Takinib effectively suppressed apoptosis via downregulation of cleaved caspase 3 and Bax and reduction of TUNEL-positive stained cell count. Thus, an enhancement of neuronal function and survival was observed post-TBI. These findings highlight the medicinal value of takinib in the management of TBI and offer an experimental justification for investigating TAK1 as a possible pharmacological target.
Overburden Failure and Water-Sand Mixture Outburst Conditions of Weakly Consolidated Overlying Strata in Dananhu No.7 Mine
Authors: Zhu Jingzhong , Li Wenping , Teng Bo , Lu Qinggang , Li Dongding , Li Liangning
Published: July 2023

This study introduces a case of weakly consolidated strata developed in Dananhu No.7 mine, and we investigate the overburden failure behaviour and the risk possibility of water-sand mixture inrush during excavation through an approach of combining numerical simulation, field measurement comparison and criterion of the critical hydraulic gradient for sand-water outburst into working sites. The following findings consist of the main conclusions. The caving zone is approximately 37.3m with a caving-mining ratio of 3.55, and the water-conducting fractured zone is 160.5m with a crack-mining ratio of 15.29 or so. The predictive results are in line with those measured in nearby and similar geological conditions mines. A crack without obvious subsidence is formed at the front edge of mining direction, and some groups of parallel stepped cracks behind the goaf could be easily observed. The subsidence characteristic of ground and below strata along the goaf center transforms an asymmetric into a symmetrical and wide-gentle “U” shape. The critical hydraulic gradients of Toutunhe Formation aquifer, aquifers of 3 coal and 3 ~ 7 coal in Xishandao Formation affected by mining are 1.314, 1.351, and 1.380, the corresponding actual hydraulic gradients are 0.692, 2.089, and 7.418. It is inferred that water-sand mixture outburst will not occur in the Toutunhe Formation aquifer, while the potential risk of outburst exists in the Xishanyao Formation aquifer. Through drainage and depressurization projects, water-sand mixture outburst accidents do not occur during excavation. The research results can lay technical and theoretical foundations for the safety mining of coal mines in western China.
An improved method for LEO orbit prediction using predicted accelerometer data
Authors: feng du , Dai Xiaolei , Peng Yaquan , Lou Yidong
Published: July 2023

The Low Earth Orbit (LEO) enhanced Global Navigation Satellite System (LeGNSS) relies on LEO satellites to broadcast GNSS-like navigation signals, providing real-time satellite orbit and clock information to enhance GNSS service performance. To ensure real-time positioning service, a period of orbit prediction becomes necessary due to the limited signal bandwidth and computation time delay. In contrast to traditional dynamic model, on-board accelerometers offer more accurate non-gravitational acceleration for LEO satellites. In this study, we improve the accuracy of short-term (1 hour) LEO satellite orbit prediction by utilizing predicted accelerometer data instead of the traditional dynamic model. We combine the Least Squares (LS) and Autoregressive (AR) methods to model and predict accelerometer data from the GRACE-A (500 km) and SWARM-A (460 km) satellites. In the experiment, the 1-hour prediction accuracy of the accelerometer data in the 3-Dimensional (3D) direction is 40.2 nm/s2 for the GRACE-A satellite and 21.7 nm/s2 for the SWARM-A satellite, respectively. When utilizing the predicted accelerometer data for 1-hour orbit predictions, the predicted orbit precision in the 3D direction is 0.21 m for the GRACE-A satellite and 0.15 m for the SWARM-A satellite, respectively. The orbit prediction accuracy shows an improvement of approximately 70% compared to the traditional dynamic model.
A Novel Deep Learning Model for Privacy based Blockchain with Electricity Theft Detection in Smart Grid
Authors: G Johncy , S Shaji R , M Angelin Monisha Sharean T
Published: July 2023

A lot of researches are being done in energy management system pertaining to intrusion detection to protect data privacy and a blockchain-based energy framework for smart-grids to detect both current and future cyberattacks. In these methods, learning-based ensemble models can assist in the identification of sophisticated malicious events while still preserving data privacy. In order to provide security, this paper proposes a privacy-based blockchain with distributed decentralized intrusion identification and electricity theft identification in smart-grids. The privacy based blockchain method is developed using BLS Short signature and hash functions. The intrusion detection method is employed by a hybrid framework leveraging Siamese Bi-LSTM for semantically discriminating malicious and authentic behaviors. In order to address the issue of class imbalance, we have used an RNN-GAN for the identification of electricity fraud. The RNN-GAN generates fake/synthesized theft samples that are very similar to actual theft instances using both supervised and unsupervised loss functions. RNN-GAN, on the other hand, even adjusts the weights of the points that are present on the accurate side of the decision boundary and keep the model from experiencing vanishing gradient problems. Additionally, batch normalization and dropout layers are used to improve the model's generalizability and speed of convergence. Our models' performance has reached great accuracy and a low error rate. Additionally, the statistical analysis demonstrates the effectiveness of the put-forth techniques.
Photosynthetic Rate and Root Growth Responses to Ascophyllum nodosum Extract–based Biostimulant in Creeping Bentgrass under Heat and Drought Stress
Authors: Zhang Xunzhong , Taylor Zachary , Goatley Mike , Wang Kehua , Brown Isabel , Kosiarski Kelly
Published: July 2023

Creeping bentgrass (Agrostis stolonifera) experiences quality decline during summer in the United States transition zone and warmer regions. Various bioproducts have been used to improve creeping bentgrass performance and to mitigate effects of summer stress in the United States transition zone. This 2-year study was carried out to examine if foliar application of seaweed extract (SWE; Ascophyllum nodosum)-based biostimulant Utilize® could enhance creeping bentgrass nitrate reductase (NaR) activity, and root viability under heat and drought stress conditions. The Utilize® was sprayed biweekly on creeping bentgrass foliage at 0, 29, 58, 87, and 116 µL⋅m−2, with application volume of 815 L⋅ha−2. Two weeks after first application, plants were exposed to heat (35/25 °C, day/night) and drought stress (40% to 50% evapotranspiration replacement) conditions for 42 days in an environment-controlled growth chamber. In general, the abiotic stress caused turf quality reduction. Foliar application of Utilize® at 58, 87, and 116 µL⋅m−2 increased turf quality, leaf color ratings, leaf chlorophyll, carotenoid content, and net photosynthetic rate (Pn). Utilize® at 58, 87, and 116 µL⋅m−2 increased NaR activity by 26.5%, 16.3%, and 16.3%, respectively, when compared with the control. Utilize® at 58, 87, and 116 µL⋅m−2 increased root biomass, root length, surface area (SA), and root volume when compared with the control. Utilize® at 58 and 87 µL⋅m−2 improved root viability by 16.3% and 30.9%, respectively, when compared with the control. Our data indicate that the SWE-based biostimulant Utilize® improves nitrogen (N) metabolism and root viability. Utilize® treatment at 58 µL⋅m−2 biweekly can be considered an effective approach for improving creeping bentgrass performance during summer stress.
Immunological Significance of Steroids and Implications for Immune Related Diseases
Authors: Ravi Sangeetha , Duraisamy Parimalanandhini , Krishnan Mahalakshmi , Catherene Martin Livya , Thiagarajan Raman , Annapoorani Angusamy , Arumugam Munuswamy , Janarthanan Sundaram , Manikandan Ramar
Published: July 2023

This book chapter compiles a general idea of steroids and their overall
biological significance in immunity and immune-associated diseases. Steroids
chemically comprise a group of cyclical organic compounds constituted by seventeen
carbon atoms that consist of four fused rings called sterane, and
cyclopentanoperhydrophenanthrene. The four-ringed structures are mainly synthesized
by mitochondria and smooth endoplasmic reticulum through the cyclization of thirty-carbon chain squalene into lanosterol or cycloartenol. Steroid hormones differ only in
number of oxygen and carbon atoms, but all are derived from cholesterol. The
biological significance of steroids and their derivatives range from energy metabolism,
and body growth to the control of reproductive activities. However, deficiency or
malfunctioning of steroids can lead to direct effects on body salt/sugar levels, sexual
differentiation and immunity. As far as immune responses are concerned, a lot of
research works have emerged which show the importance of steroids in immune
regulation, and in extreme cases, they are also known to result in immune-related
diseases. Most of these effects are mediated by the influence of steroids on gene
expression in cells and this could in turn prove to be novel drug targets as well. We
have made an attempt in this chapter to update and highlight the role of steroids in
immune regulation and immune-related diseases, which we hope would open up
therapeutic options for diseases.
MENINGKATKAN KEAMANAN TERHADAP SQL INJECTION STUDI KASUS SISTEM KEPEGAWAIAN BNN
Authors: Yulia Andarini Rachmawati , Hendradi Purwono , Nugroho Setiya
Published: July 2023

Abstrak

Di era perkembangan digitalisasi yang sangat pesat ini, SQL injection merupakan sebuah bahasa pemrograman seperti PHP atau Perl mengakses database melalui SQL query atau xampp. Penetration Testing merupakan salah satu metode untuk menguji kelengkapan, keterpaduan, operasional dan dasar dunia komputer yang terdiri dari perangkat keras, perangkat lunak dan manusia. Badan Narkotika Nasional Kabupaten Magelang telah mengembangkan website untuk absensi non pegawai negeri/polri secara lokal. Manfaat website bagi pegawai non pns/polri adalah dapat mengurangi human error dan meningkatkan efektivitas kerja. Aplikasi Sistem Informasi Manajemen Kepegawaian ASN(SiMPaN) dapat diakses oleh semua pegawai sehingga tidak menutup kemungkinan terjadi berbagai serangan yang dilakukan oleh cracker, sedangkan data dan informasi di dalamnya bersifat sensitif karena berhubungan dengan data pribadi dan berkas pelaporan bulanan pegawai. Penelitian ini dibuat untuk membuat keamanan pada Sistem Informasi Manajemen Kepegawaian BNNK Magelang(SiMPaN). Hasil perbandingan penambahan SSL dan menambahkan kode captcha. Keduanya dapat digunakan untuk meminimalisir terjadinya penembusan pada bagian login dengan fungsi masing-masing.

 
Wybrane uwarunkowania ekonomiczne rozwoju innowacyjnych struktur integracyjnych w agrobiznesie
Authors: Chorób Roman
Published: July 2023

W opracowaniu zaprezentowano teoretyczne podstawy, zasady funkcjonowania oraz korzyści płynące z efektywnie funkcjonujących innowacyjnych powiązań integracyjnych, jakimi są struktury klastrowe. W opracowaniu podjęto próbę wskazania społeczno-ekonomicznych uwarunkowań rozwoju tych związków. Prawidłowo funkcjonujące, jak również tworzące się struktury integracyjne występujące w gospodarce są jednym z istotnych warunków jej dynamicznej ekspansji.
Wpływ środków pomocowych WPR 2007-2013 na zmiany w wybranych gospodarstwach rolnych
Authors: Kiełbasa Barbara
Published: July 2023

Artykuł przedstawia cząstkowe wyniki badań prowadzonych na próbie 60 gospodarstw różniących się pod względem wielkości ekonomicznej z trzech województw: łódzkiego, małopolskiego i opolskiego. Badania realizowano metodą wywiadu bezpośredniego z kierownikami indywidualnych gospodarstw rolnych. Większość kierowników badanych gospodarstw uznała, że integracja europejska miała istotny wpływ na szybkość wdrażania innowacji w gospodarstwach. W wielu przypadkach była czynnikiem wymuszającym zmiany i dostosowanie gospodarstw do wymogów panujących na rynku europejskim.
Application of Nutritional Marketing Tools in Press Advertisements
Authors: Rejman Krystyna , Halicka Ewa , Walkowska Sylwia
Published: July 2023

In chosen periodicals of the food industry and so-called “women’s press,” food advertisements containing nutritional marketing messages were analysed. The frequency and type of these tools was observed and scientific value and correctness was evaluated. The study results show that most of the advertisements do not comply with current legal regulations. Producers often emphasize the presence of ingredients which are recommended from the nutritional point of view although the product’s overall nutritional value is low or controversial.
18. YÜZYILIN İKİNCİ YARISINDA ŞAM HAZİNESİ NİN BİR MASRAF KALEMİ OLAN CEVÂLÎ NİN MESELELER
Authors: Korkmaz Samikıran Günay
Published: July 2023

Şam eyaletinde cizyenin küçük bir kısmı ve çeşitli mukataa gelirlerinin yıllık
vergilerinin belli payları cevâlî ismindeki mali bir dairede toplanmış ve burada toplanan
paralar “sadaka”, “surre”, “maaş ve ücret” şeklinde bazı kişilere sarf edilmiştir.
Cevâlîden yapılan ödemeler Şam Hazinesi’nin başlangıçta ikinci büyük masraf maddesini
oluşturmuştur. Ancak 1745’te hac kilerine sarf edilen paranın hazine gelirleri arasında
artık yer almayacağına yönelik alınan kararla cevâlî hazinenin en büyük harcama kalemi
hâline gelmiştir. Özellikle 18. yüzyılın ikinci yarısından itibaren cevâlîden verilen
vazîfeler (ücretler) sürekli bir artış göstermiştir. Artan cevâlî vazîfeleri karşısında
Osmanlı Devleti, mahlûl (düşen/boşalan) vazîfenin hazinece zapt edilmesi ve
mahlûlâtdan takâss gibi yollara başvurmuştur. Bu hususta alınan son karar ise 1811’de
cevâlîden yapılacak vazîfe tevcihlerinde cizye ve mukataa gelirlerinin yıllık vergilerine
zam yapılamayacağıdır. 1811 senesinde maaş tevcihlerine yönelik karar sadece Şam için
alınmamış, İstanbul’da ve taşrada artan vazîfeler karşısında buralara da tatbik edilmiştir.
Çalışmanın ilk kısmında cevâlî malından (para) maaş ve ücret alan cevâlî-horânın kimler
olduğuna değinilmiş ve bunların aynı zamanda deruhteci olabildiklerine dikkat
çekilmiştir. Ardından cevâlî vazîfelerinin nasıl hesaplandığı ve hesaplama esnasında
karşılaşılan mesele ve artan cevâlî vazîfeleri karşısında devletin tavrı açıklanmaya
çalışılmıştır. Son olarak Şam Hazinesi muhasebelerinde cevâlî vazîfelerinin miktarları
değerlendirilmiştir. Bahsedilen tüm bu meseleler Başkanlık Osmanlı Arşivine dayanarak
neticelendirilmeye çalışılmıştır.
Budaya Seiri, Seiton, Seiso, Seiketsu, dan Shitsuke di Industri Kecil Menengah Kerupuk Azizah
Authors: Rahmayanti Dina , Afrinaldi Feri , Patrisina Reinny , Meuthia Yumi , Zadry Hilma Raimona , Susanti Lusi , Fithri Prima , Jumeno Desto , Ramadhan Luthfi Fakhri
Published: July 2023

This community service activity was carried out by designing a cabinet for finished products and handing over the cabinet to a small and medium industry producing various types of crackers, namely IKM Kerupuk Azizah. IKM Kerupuk Azizah used open shelves to store packaged finished products. This practice was unhygienic and risky. Animals like rats and insects ate and damaged the materials and products. In addition, the warehouse needed to look more tidy. Moreover, from an aesthetic point of view, it was unattractive. A storage cabinet was designed to solve this problem. In designing the cabinet, available space, the number of piles of finished products, and the dimensions of the packaged finished products were considered. The results showed that, with a storage cabinet for finished products, IKM Kerupuk Azizah improved products’ quality and hygiene so that consumers would have more confidence in purchasing the products. In addition, IKM Kerupuk Azizah also applied the Seiri, Seiton, Seiso, Seiketsu, and Shitsuke (5S) principles in their work environment to create a clean, healthy, and comfortable workplace.
Optimalisasi Produksi Lebah Madu Galo-Galo dengan Penanaman Vegetasi Berbunga di Sungkai, Kelurahan Lambung Bukik, Padang
Authors: Rusdimansyah Rusdimansyah , Hidrayani Hidrayani , Ikhsan Zahlul
Published: July 2023

One of the things that can be done to increase production in Galo-Galo beekeeping is to plant flowering vegetation around the cultivation location. Some flower plants that are good for planting are Mexican Creeper, Xanthostemon, and Calliandra. These three plants can attract Galo-Galo honey bees to increase honey production. They will be able to improve the farmer's economy in Sungkai, Lambung Bukik Village, and Pauh Padang District. This community service activity aimed to provide understanding and flowering plant seeds to increase the production of Galo-Galo bee honey. The method used was counselling and practice. Planting flower vegetation was carried out in practice directly at the farm location. The activity resulted in 1) Increased partners' knowledge, interest, and skills in breeding Galo-Galo integrated with flowering vegetation. 2) Partners know and can increase the productivity of Galo-Galo bee honey. The activity ran smoothly, and the activity target was appropriately achieved. Farmers participating in the service have been able to cultivate stingless bees and optimize production by planting flowering vegetation.
Millions of years of evolution at stake on Madagascar
Authors: Michielsen Nathan
Published: July 2023

The mammals of Madagascar have seen many human induced extinctions while increasing human influence mean many more may follow. We show that adding to the few million years of evolutionary history that have already been lost, many more millions of years would be needed to regain the lost diversity if proper conservation measures are not employed.
RESEARCH OF TECHNICAL BAST FIBERS
Authors: Задворных Г.С. , Блазнов А.Н. , Бычин Н.В. , Сакошев Е.Г. , Сакошев З.Г. , Фирсов В.В. , Медведев П.А. , Кортусов А.Н.
Published: July 2023

Рассмотрена лубяная техническая культура конопля, сегмент по выращиванию и переработке которой в России развивается быстрыми темпами. На примере мировых тенденций показаны возможности и перспективы использования лубяных волокон конопли для биоразлагаемых композитов на растительной основе. Исследованы режимы выделения лубяных волокон методом химического реттинга. С помощью химического анализа определено содержание целлюлозы, лигнина, пентозанов в выделенных волокнах исходном растительном сырье. Методом ТМА измерены значения прочности 177-548 МПа, деформации при разрушении 0,7-2,5 % и модуля Юнга 13,2-43,5 ГПа, при толщине технических волокон от 50 до 140 мкм. Полученные результаты согласуются с известными данными других авторов и находятся на уровне свойств лубяных волокон культур – крапивы, льна, применяемых в композиционных материалах. Выделенные технические волокна конопли имеют достаточно высокие упруго-прочностные характеристики, а их длина 200-400 мм позволяет создавать армированные композитные материалы на их основе.

The bast technical crop hemp is considered, the segment for the cultivation and processing of which is developing rapidly in Russia. On the example of global trends, the possibilities and prospects of using hemp bast fibers for biodegradable plant-based composites are shown. The modes of isolation of bast fibers by chemical retting were investigated. Chemical analysis was used to determine the content of cellulose, lignin, and pentosans in the isolated fibers of the original plant material. The TMA method measured strength values of 177-548 MPa, deformation at fracture of 0.7-2.5% and Young's modulus of 13.2-43.5 GPa, with a thickness of technical fibers from 50 to 140 microns. The results obtained agree with the known data of other authors and are at the level of properties of bast fibers of crops - corn, flax, used in composite materials. The selected technical hemp fibers have sufficiently high elastic-strength characteristics, and their length of 200-400 mm makes it possible to create reinforced composite materials based on them.
STUDY OF THE TECHNOLOGICAL PARAMETERS OF A METAL-COMPOSITE PRESSURE VESSEL WINDING
Authors: Кузьмин А.А. , Рыжова Т.М.
Published: July 2023

В работе исследуется изотропный тонкостенный герметизирующий лейнер металлокомпозитного баллона, также являющийся неизвлекаемой технологической оснасткой, который должен оставаться неповреждённым как в процессе изготовления металлокомпозитного баллона, так и на этапе его эксплуатации. Проанализированы параметры процесса автоматизированной намотки, влияющие на характеристики материала и скорость изготовления баллонов, из которых наиболее важным является сила натяжения ленты наматываемого материала, приводящая к возникновению внешнего давления и возможной потере устойчивости лейнера. Разработан и приведён алгоритм определения технологических параметров намотки, исключающих потерю устойчивости лейнера и даны рекомендации по выбору оптимальных параметров изготовления металлокомпозитных баков при помощи «мокрой» автоматизированной намотки.

The paper investigates an isotropic thin-walled sealing liner of a metal-composite cylinder, which is also a non-removable technological equipment, which must remain intact both during the manufacture of a metal-composite cylinder and at the stage of its operation. The parameters of the automated winding process that affect the characteristics of the material and the speed of manufacturing cylinders are analyzed, of which the most important is the tension force of the tape of the wound material, which leads to the appearance of external pressure and possible loss of stability of the liner. An algorithm for determining the technological parameters of winding, which excludes the loss of stability of the liner, has been developed and presented, and recommendations are given for choosing the optimal parameters for the manufacture of metal-composite tanks using "wet" automated winding.
A SAM-key domain required for enzymatic activity of the Fun30 nucleosome remodeler
Authors: Karl Leonhard A , Galanti Lorenzo , Bantele Susanne CS , Metzner Felix , Šafarić Barbara , Rajappa Lional , Foster Benjamin , Pires Vanessa Borges , Bansal Priyanka , Chacin Erika , Basquin Jerôme , Duderstadt Karl E , Kurat Christoph F , Bartke Till , Hopfner Karl-Peter , Pfander Boris
Published: July 2023

Fun30 is the prototype of the Fun30-SMARCAD1-ETL subfamily of nucleosome remodelers involved in DNA repair and gene silencing. These proteins appear to act as single-subunit nucleosome remodelers, but their molecular mechanisms are, at this point, poorly understood. Using multiple sequence alignment and structure prediction, we identify an evolutionarily conserved domain that is modeled to contain a SAM-like fold with one long, protruding helix, which we term SAM-key. Deletion of the SAM-key within budding yeast Fun30 leads to a defect in DNA repair and gene silencing similar to that of thefun30Δ mutant. In vitro, Fun30 protein lacking the SAM-key is able to bind nucleosomes but is deficient in DNA-stimulated ATPase activity and nucleosome sliding and eviction. A structural model based on AlphaFold2 prediction and verified by crosslinking-MS indicates an interaction of the long SAM-key helix with protrusion I, a subdomain located between the two ATPase lobes that is critical for control of enzymatic activity. Mutation of the interaction interface phenocopies the domain deletion with a lack of DNA-stimulated ATPase activation and a nucleosome-remodeling defect, thereby confirming a role of the SAM-key helix in regulating ATPase activity. Our data thereby demonstrate a central role of the SAM-key domain in mediating the activation of Fun30 catalytic activity, thus highlighting the importance of allosteric activation for this class of enzymes.
Study of urban infrastructure elements for personal mobility devices safe movement
Authors: Donchenko V. V. , Kupavtsev V. A.
Published: July 2023

Introduction. Despite the introduction of new amendments to the rules of the road, accidents involving personal mobility device (PMD) continue to occur on the roads of the Russian Federation. The analysis of statistical indicators makes possible to determine that more than 90% of accidents occur in populated areas, with the participation of PMDs equipped with electric motor mainly collisions with vehicles, with less powerful, not equipped with electric motor mainly collisions with pedestrians occur, which indicates certain chosen conditions for driving - the roadway and sidewalks. In addition, it was found that in these cases, one of the emerging types of accidents is tipping, associated primarily with the available elements on sections of city streets and city roads, which have a certain height above the level of roads and sidewalks. In order to determine the possibility of a overturning taking these elements into account, the analysis of the urban infrastructure was determined, the main elements that pose a risk to PMD traffic were identified, their geometric parameters were established and a mathematical calculation of the traffic conditions was carried out in the study. Methods and materials. As materials and methods for the study, the methods of statistical analysis and mathematical calculations were defined. Results. As a result of the calculation, the authors identified the elements of the urban infrastructure that are dangerous for the movement of the PMD, when interacting with which, with a high degree of probability, the device in question will overturn and injure the driver of the PMD. Conclusion. The calculations have identified the main hazardous elements located on the city streets and urban roads. It was found that the process of overturning is influenced by the geometric characteristics of the device. In view of the obtained results, the perspective directions of improvement of traffic safety in urban transport systems - development of requirements for safety PMD and creation of specialized infrastructure for the safe movement of the PMD in the conditions of modern cities were determined.
Open Innovation Emerging Challenges and Practices in Brazil
Authors: Josgrilberg Fabio Botelho , Hashiba Luciana , Mello Renata
Published: July 2023

Purpose:  The purpose of this paper is to identify the best practices and challenges of innovation management in large companies in Brazil.
 
Theoretical framework: This paper draws upon recent literature on open innovation, with particular attention to communication processes and challenges. The research adopts Chesbrough´s open innovation (OI) definition and develops its argument from Mortara and Minshall´s proposal of OI high-level trends (CHESBROUGH; VANHAVERBEKE; WEST, 2006; MORTARA; MINSHAL, 2017).
 
Design/methodology/approach: The researchers conducted qualitative research of eleven interviews with innovation leaders of big multinational companies. The corpus was submitted to a framework analysis, which allowed for identifying 63 emerging themes, structured in a thematic framework that supported the interpretation procedure.
 
Findings: Key findings include the development of five emerging categories of management types, innovation drivers, and communicational dimensions.
 
Research, Practical & Social implications: The research draws attention to the impact of complexification in open innovation strategies, and the need for new models of governance, communicative functions, and innovation drivers.
 
Originality/value: The results support the emerging, but yet scarce, literature on open innovation in Brazil, and identify key challenges and emerging practices among Brazilian managers in large companies.
Te Whare Kōrero
Authors:   , Te Maro Amy
Published: July 2023

Kia ū ki tou kāwai tīpuna, Kia mātauria ai, I ahu mai koe ihea, e anga ana koe ko hea.

Trace out your ancestral stem, so that it may be known where you come from and where you are going. (He Māori ahau: I am Māori, 2015).

This thesis is a restoration project for myself to reconnect with my cultural identity as an urban Māori. I hope it may also offer value to other urban Māori, especially tauira, to build the courage to explore their Māoritanga throughout their area of work or education.

Identities are the foundations of this research project. I am a descendant of Ngāti Porou, and although this background ultimately underlies everything I make, do, and write, it is not the objective of this research project to be limited to any one iwi perspective. This research project is for all dislocated urban Māori to come together and reconnect with their cultural identity in the urban environment. It is essential to acknowledge the politics that influence culture and the social, multicultural, and colonial forces that construct and change individual cultural identities because Māori culture is highly diverse. While I acknowledge that most interview participants are affiliated with Ngāti Porou and myself, this is due to already established relationships and the given timeframe of a master’s level thesis. The rangahau/research aims to understand the transition to the urban environment through an architectural lens as opposed to visualising Ngāti Porou identity in the urban environment. Everyone perceives identity and architecture differently; this rangahau aims not to make Māori identity seem generalised but rather embrace the commonalities of identity and architecture.

This research project intends to highlight the essence of contemporary Māori identity by unpacking and understanding whakawhanaungatanga through an interior architectural lens. Whakawhanaungatanga is explored through an architectural lens of a design investigation at Papa’s whare/house, 85 Bird Grove in Stokes Valley, a state house style built in 1968. To visualise whakawhanaungatanga within interior architecture, the research project investigates the potential of whakapapa as a method for making and rethinking the way we design a kāinga/home as opposed to a whare. Through layered explorations, “Whakapapa of Potential” concludes an outcome of a nuclear whānau/family domestic interior. The focus is to weave and layer research and design to create spaces for gathering, discussions, learning, engaging and belonging, thus encouraging whakawhanaungatanga.

Along with the academic outcomes of this thesis, I have had the greatest gift of creating and maintaining reciprocal relationships with my whakapapa connections, deepening whanaungatanga.
Punctuation variation in poetic texts by G. R. Derzhavin (to the 280th anniversary of the birth)
Authors: Lebedev A. A.
Published: July 2023

The article analyses the punctuation differences in G. R. Derzhavin’s poetical works in various editions. In addition, the research considers the influence of such differences on the formation of syntactic constructions and on readers’ perception of the text of a particular work. Modern essay collections, as well as other sources including the poet’s writings, contain punctuation discrepancies which can affect the understanding of the message of texts. The article analyses seven poems by G. R. Derzhavin ("Picnics", "Drowning", "To the Lyre", "Wealth", "Chains", "Hunter", "To Plamida") in detail. Using quantitative and contrastive-comparative analysis, the article aims to identify the main punctuation differences between two collections of poems by G. R. Derzhavin published in the 19th century. Another objective is to evaluate their influence on modern collections of poems. The research identifies the most typical variation types, for example, variation manifested at sentence boundaries. Other types are the presence of a punctuation mark in one edition and its absence in the other, a colon and its replacement with another punctuation mark, the choice between a comma and a semicolon. The paper particularly considers punctuation variables in cases with two or more epithets accompanying one noun, as well as in constructions with an antithesis. The analysis demonstrates the high complexity of punctuation and its inconsistency in the poet’s texts. The study also confirms the need for a more thorough investigation of the syntax in G. R. Derzhavin’s poetical works based on his punctuation dating back to the "Complete Scientific Collection of Derzhavin’s writings edited by Ya. Grot".
Detection of Epstein-Barr Nuclear Antigen (EBNA) IgM among healthcare workers in some selected hospitals in Rivers State, Nigeria
Authors: Okonko Iheanyi Omezuruike  , Oyasope Segun Samuel  , Enya Emmanuel  , Awanye Amaka Mirian
Published: July 2023

Several diseases are associated with Epstein-Barr virus (EBV) and they can be life-threatening, especially in immunocompromised individuals. Moreover, there are no well-established EBV prevention and control strategies in Nigeria. Therefore, this study was carried out to assess the prevalence of Epstein-Barr (EBNA) IgM antibody among Public Health Workers in Port-Harcourt, Nigeria. A cross-sectional survey was adopted to randomly analyze 94 public healthcare workers (HCWs) working in a public health centre in Rivers State, Nigeria. Enzyme-Linked Immunosorbent Assay (ELISA) was used to analyze EBNA IgM antibodies in the samples obtained. Chi-Square analysis was used to determine the association of the infection with socio-demographic factors. Overall, 3 patients were seropositive for EBNA IgM, constituting 3.1% of the sample while 91 (97.8%) were observed to be seronegative for EBNA IgM antibody. Reactivity of Epstein–Barr virus did not differ significantly as regards sex distribution, but it was significant with regards to marital status and professional cadre in the health care facility. Sera EBNA IgM positivity was highest in the age group >40 (9.5%) followed by the age group 18-29 (5%), single (4%), married (3.2%), male (9.5%), female (1.3%). This study confirms the presence of Epstein-Barr virus primary infection among public health workers in Port-Harcourt, and an onward risk of infectious mononucleosis. This finding, therefore, alerts us to the establishment of surveillance programs for the detection, treatment and control of EBV in Port-Harcourt and Nigeria at large.
Evaluation of cerebral neurological complications in patients with infective endocarditis: results of a single-center retrospective study
Authors: Demin D. A. , Kulesh A. A. , Enginoev S. T. , Demetskaya V. V. , Kozmin D. Yu. , Demina E. V. , Stompel D. R. , Astanin P. A.
Published: July 2023

Abstract. Cerebral neurological complications (CNC) are the most common form of infective endocarditis (IE) extracardiac manifestations. They have important clinical implications, which justifies the need to study them.

Purpose of the study: to evaluate symptomatic CNC (prevalence, predictors, effect on the prognosis) in patients with «left-sided» IE who have undergone cardiac surgery, according to the register of the Federal Center for Cardiovascular Surgery.

Materials and methods. A retrospective review of data from the hospital information system was carried out in one of the Federal Centers for Cardiovascular Surgery of the Ministry of Health of the Russian Federation. In patients with significant/probable «left-sided» (mitral and/or aortic valves) acute/subacute IE at age of ≥ 18 years, the frequency of CNC and their subtypes was assessed, predictors and effect on the prognosis of the disease were determined. Differences between groups of patients depending on the status of the presence of CNC were assessed using the χ2 test, Fisher’s exact test and the Mann–Whitney test. Binary cross tables were further analyzed to calculate the odds ratio (OR). Integral predictive models were also built using the logistic regression algorithm. To assess the effect of CNC on patient survival, Kaplan–Meier analysis was used with the construction of survival curves.

Results. For the analysis, 222 cases of IE in 216 patients were used. The incidence of CNC was 25.7% (19.4% – ischemic stroke, 5.4% – intracranial hemorrhage, 2.7% – meningitis, encephalitis and/or abscess). CNC predictors were embologenic vegetations: size > 10 mm (OR 6.3; 95% CI: 3.0–13.0), mobile (OR 8.5; 95% CI: 3.2–22.3) and multiple (OR 4.9; 95% CI: 2.1–11.4) vegetation; the level of white blood cells ≥ 10 × 109/L (OR 2.1, 1.1–3.8), as well as systemic embolism (OR 3.6; 95% CI: 1.6–7.9). The accuracy of the logistic regression model obtained using the above predictors was 83% (on the test set). No effect of CNC on the prognosis (in-hospital and long-term mortality, stroke in the long-term period) was found.

Conclusion. Neurological complications have a high prevalence, occurring in one in four patients with «left-sided» IE. Ischemic stroke is the most common subtype of CNC, and vegetation characteristics are a determining factor of the embologenic potential of endocarditis. There was no effect on the prognosis (in-hospital and long-term mortality) in patients undergoing cardiac surgery.
The effect of nutritional insufficiency on clinical outcomes of patients with acute ischemic stroke
Authors: Naprienko M. V. , Ramazanov G. R. , Novikova T. V.
Published: July 2023

Acute cerebrovascular accident is one of the main causes of disability in patients and has a significant impact on the functions of daily activity and the ability to self-care. With the improvement of methods of medical care and the increase in patient survival, active rehabilitation of patients is becoming increasingly important. Malnutrition and loss of muscle mass are among the most frequent complications associated with a decrease in rehabilitation potential and an increased risk of adverse outcomes, and therefore the issues of timely assessment and correction of nutritional deficiency are relevant for all specialists of the interdisciplinary team that takes part in the rehabilitation treatment at all stages of rehabilitation
WHOLESALE DISTRIBUTION AS A COMPONENT OF THE FOOD SECURITY SYSTEM
Authors: Sapunova Mariya
Published: July 2023

Introduction. The article examines the infl uence of organizations in the fi eld of wholesale distribution on the physical and economic availability of food products. Currently, the domestic food market is undergoing a number of changes affecting the achievement of an acceptable level of food assortment of high-quality and safe consumer goods. Despite the high level of self-suffi ciency in agricultural products, there is a threat to food security due to the existing system of ensuring the availability of produced resources to end consumers. The purpose of the article is to substantiate the positive impact of the activities of distribution companies on the dynamics of food trade within the country, strengthening the economy and food security in general. Methodology. Studying wholesale distribution as a component of the food security system was based on the methods of logical statistical analysis. The study was based on data from Federal State Statistics Service. Results. The research included calculation, analysis and assessment of self-suffi ciency level in agricultural products. Furthermore, we identifi ed the share of participation of wholesale distribution organizations in the turnover of food products. Proposals aimed at supporting the activities of wholesale distribution organizations were presented. Conclusions. The creation of favorable conditions for the movement of food products within the country can cause a positive effect in terms of import substitution. The development of commodity fl ows of products carried out by distributors may provide the state to more effectively regulate commodity and fi nancial fl ows in the domestic food market.
УДОСКОНАЛЕННЯ БАГАТОКАНАЛЬНОЇ РАДІОТЕХНІЧНОЇ СИСТЕМІ НА FPGA ДЛЯ ЧАСТОТНИХ ПЕРЕТВОРЮВАЧІВ ФІЗИЧНИХ ВЕЛИЧИН ПІДТРИМКОЮ ЦИФРОВИХ СЕНСОРІВ
Authors: ОСАДЧУК Олександр , ОСАДЧУК Ярослав , СКОЩУК Валентин
Published: July 2023

У роботі представлено розробку функціонального розширення можливостей багатоканальної радіотехнічної системи паралельного вимірювання частотних інформативних сигналів на основі FPGA фірми Altera Cyclone IV. Основною задачею розробленої системи є вимірювання інформативного параметру сенсорів фізичних величин з частотним виходом, за допомогою підтримки цифрових сенсорів. Удосконалено багатоканальний універсальний вимірювальний прилад на основі FPGA, який має 12 паралельних вимірювальних каналів для сенсорів з частотним виходом та інтегрованим мікропроцесорним ядром NIOS II. Удосконалено внутрішню конфігурацію мікропроцесорного ядра NIOS II,  синтезовано блок ядра, створено апаратну реалізацію I2C інтерфейсу, додано програмну підтримку I2C протоколу, реалізовано програмну підтримку трьох цифрових сенсорів, оновлено і повторно синтезовано загальну схему. Інтеграція  I2C протоколу у багатоканальний частотомір дозволяє одночасне вимірювання значень з двох типів сенсорів, що значно розширює спектр можливих шляхів використання радіотехнічної інформаційно-вимірювальної системи.
ОЦІНЮВАННЯ НАДІЙНОСТІ ВИРОБІВ ЕЛЕКТРОННОЇ ТЕХНІКИ ЗА РІВНЕМ НИЗЬКОЧАСТОТНИХ ШУМІВ
Authors: МИХАЛЕВСЬКИЙ Дмитро , СТАЛЬЧЕНКО Олександр
Published: July 2023

У статті представлено результати дослідження для розширення можливостей контролю виробів електронної техніки за рівнем низькочастотних шумів для оцінювання кількісних параметрів надійності. Це дає можливість виробникам електроніки визначати відповідні границі допустимих рівнів шуму, на основі яких можна забезпечити відповідний рівень надійності та стабільної роботи пристроїв на основі виробів електронної техніки.

Досліджено нестаціонарний процес деградації внутрішньої структури виробів електронної техніки на основі інформативного параметра та випадкової похибки для визначення параметрів надійності. Виявлено, що такий процес є подібним до лінійного закону та характеризується математичним очікуванням і дисперсією. Отримано узагальнений аналітичний вираз для випадкового процесу функції надійності виробів електронної техніки, який пов’язує середньоквадратичне значення шумової напруги, границі придатності та інтервал напрацювання на відмову. Параметри функції надійності можуть бути розраховані на основі статистичної обробки результатів експериментальних досліджень.

Встановлено, що рівень власних шумів з часом зростає за законом близьким до лінійного, і випадковий процес зміни інформативного параметра в часі є близьким до моделі лінійної регресії, Це також має місце і для деградації внутрішньої структури.
УДОСКОНАЛЕННЯ МЕТОДУ ПОВІРКИ ЛІЧИЛЬНИКІВ ВОДИ
Authors: ЛАБУНСЬКИЙ Вадим , ЗАЩЕПКІНА Наталія , ЛАБУНСЬКА Анастасія
Published: July 2023

З кожним роком використання води населянням збільшується. І це проблема не тільки екологічна, а й проблема виживання людини в наш час. Особливо гострою вона встала зараз під час військового вторгнення на територію України. Знищується екологія нашої країни, особливо потерпають від залишків нелюдської поведінки загарбників наші річки. Населення вже не раз під час війни стикалось з нестачею води. Тому проблема економного використання та споживання води є актуальною.

Цю проблему, як і багато інших, вирішували через заощадження коштів в побуті, шляхом використання лічильники води.  Досвід використання побутових лічильників води довів свою доцільність та ефективність, бо саме, використання таких лічильників дає можливість реальної економії як обємів води, так і коштів, бо  оплачувалось  тільки за кількість фактично спожитої води.

Кількість лічильників води, встановлених у квартирах, постійно збільшується та  разом з цим, дедалі більша кількість таких лічильників вимагають проведення планової повірки. Причина - з часом точність вимірювань знижується та збільшується похибка, внаслідок чого досить часто страждають мешканці. Фактором погіршення метрологічних характеристик лічильників є інтервал часу роботи приладу та умови, за яких він функціонує. Чинникі, які впливають на невірні показники мають різну природу. Тому повірка лічильників є обов’язковою для всіх користувачів.

Розроблений удосконалений метод повірки лічильників на місці. Здійснення повірки на місці експлуатації лічильників дозволило зменшити вартість та час надання послуги з повірки. Додатковий ефект від оптимізації процесу повірки лічильників води полягає в тому, що повірки проводяться з урахуванням особливостей монтажу лічильників.