bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment Planning Study for Microbeam Radiotherapy Using Clinical Patient Data
Authors: Kraus Kim Melanie , Winter Johanna , Zhang Yating , Ahmed Mabroor , Combs Stephanie Elisabeth , Wilkens Jan Jakob , Bartzsch Stefan
Published: January 2022

Microbeam radiotherapy (MRT) is a novel, still preclinical dose delivery technique. MRT has shown reduced normal tissue effects at equal tumor control rates compared to conventional radiotherapy. Treatment planning studies are required to permit clinical application. The aim of this study was to establish a dose comparison between MRT and conventional radiotherapy and to identify suitable clinical scenarios for future applications of MRT. We simulated MRT treatment scenarios for clinical patient data using an inhouse developed planning algorithm based on a hybrid Monte Carlo dose calculation and implemented the concept of equivalent uniform dose (EUD) for MRT dose evaluation. The investigated clinical scenarios comprised fractionated radiotherapy of a glioblastoma resection cavity, a lung stereotactic body radiotherapy (SBRT), palliative bone metastasis irradiation, brain metastasis radiosurgery and hypofractionated breast cancer radiotherapy. Clinically acceptable treatment plans were achieved for most analyzed parameters. Lung SBRT seemed the most challenging treatment scenario. Major limitations comprised treatment plan optimization and dose calculation considering the tissue microstructure. This study presents an important step of the development towards clinical MRT. For clinical treatment scenarios using a sophisticated dose comparison concept based on EUD and EQD2, we demonstrated the capability of MRT to achieve clinically acceptable dose distributions.
Fluorescence Imaging of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Resistance in Non-Small Cell Lung Cancer
Authors: Martin-Fernandez Marisa L.
Published: January 2022

Non-small cell lung cancer (NSCLC) is a complex disease often driven by activating mutations or amplification of the epidermal growth factor receptor (EGFR) gene, which expresses a transmembrane receptor tyrosine kinase. Targeted anti-EGFR treatments include small-molecule tyrosine kinase inhibitors (TKIs), among which gefitinib and erlotinib are the best studied, and their function more often imaged. TKIs block EGFR activation, inducing apoptosis in cancer cells addicted to EGFR signals. It is not understood why TKIs do not work in tumours driven by EGFR overexpression but do so in tumours bearing classical activating EGFR mutations, although the latter develop resistance in about one year. Fluorescence imaging played a crucial part in research efforts to understand pro-survival mechanisms, including the dysregulation of autophagy and endocytosis, by which cells overcome the intendedly lethal TKI-induced EGFR signalling block. At their core, pro-survival mechanisms are facilitated by TKI-induced changes in the function and conformation of EGFR and its interactors. This review brings together some of the main advances from fluorescence imaging in investigating TKI function and places them in the broader context of the TKI resistance field, highlighting some paradoxes and suggesting some areas where super-resolution and other emerging methods could make a further contribution.
Copper Supported on Mesoporous Structured Catalysts for NO Reduction
Authors: Felgueiras Mariana B. S. , Restivo João , Sousa Juliana P. S. , Pereira Manuel F. R. , Soares Olívia S. G. P.
Published: January 2022

Nitrogen oxides (NOx) are one of the pollutants of greatest concern in terms of atmospheric contamination and, consequently, human health. The main objective of this work, is the synthesis of structured carbon catalysts, introducing on their surface metals and nitrogen groups, catalytically active in NO reduction. Structured catalysts represent an attractive alternative to powder catalysts because they have better thermal stability and lower pressure drop. The catalysts were synthesized by coating a melamine foam using precursor solutions of carbon xerogels with and without nitrogen (using melamine and urea as precursors), and impregnated with transition metals (Fe, Ni and Cu). The introduction of nitrogen and metals modified the textural properties of the materials. Samples synthesized with melamine presented the highest amount of nitrogen, while the highest content of copper, found to be the most active transition metal for NO reduction, was found in structured catalysts impregnated with urea. The presence of transition metals in catalysts is essential for the reduction of NO to N2 and the introduction of nitrogenous precursors makes this evident. The synthesis and application of carbon-supported structured catalysts containing transition metals for NO reduction is demonstrated in this work for the first time, as well as the study of the factors influencing their performance.
Enzymatic Desymmetrisation of Prochiral Phosphines and Phosphine P-Sulfides as a Route to P-Chiral Catalysts
Authors: Madalińska Lidia , Kiełbasiński Piotr , Kwiatkowska Małgorzata
Published: January 2022

The enzyme-catalyzed monoacetylation of prochiral bis (2-hydroxymethylphenyl)methylphosphine and bis (2-hydroxymethylphenyl)phenylphosphine and their P-sulfides gave, in one single step, as a result of desymmetrisation, the corresponding monoacetates in moderate yields and with an enantiomeric excess of 16 to 98%, depending on the substrate structure and enzyme applied. The absolute configurations of the selected products were determined by a chemical correlation. This led to the conclusion that, in the case of phosphines, phosphine oxides and phosphine sulfides enzymes preferentially produce compounds of the same spatial arrangement. The new compounds obtained will be transformed into chiral catalysts/ligands.
The Bibliometric Analysis and Review of the Application of Plasma in the Field of VOCs
Authors: Xing Yi , Zhang Wenbo , Su Wei , Zhang Hui , Wang Jiaqing , Zhang Hongshuo , Guo Zefeng , Jia Haoqi
Published: January 2022

The application of plasma in the field of volatile organic compounds (VOCs) can be traced back to the 1990s and has gradually developed into an important research field. In this regard, this article primarily sorts and analyzes the literature on the “application of plasma in the field of VOCs” in the Web of Science core collection database from 1992 to 2021 and, subsequently, obtains important data and trends, including the annual number of articles published, country, institution analysis, and journal, as well as discipline analysis, etc. The results show that China is not only in a leading position in the field of research, but also has six top-ten research institutions. This field has more research results in engineering, chemistry, physics, and environmental disciplines. In addition, this article summarizes dielectric barrier discharge (DBD) and titanium-containing catalysts, which represent the discharge characteristics and type of catalyst highlighted through the hot keywords. This review will provide certain guidance for future, related research.
Zscan4 Contributes to Telomere Maintenance in Telomerase-Deficient Late Generation Mouse ESCs and Human ALT Cancer Cells
Authors: Dan Jiameng , Zhou Zhongcheng , Wang Fang , Wang Hua , Guo Renpeng , Keefe David L. , Liu Lin
Published: January 2022

Proper telomere length is essential for indefinite self-renewal of embryonic stem (ES) cells and cancer cells. Telomerase-deficient late generation mouse ES cells and human ALT cancer cells are able to propagate for numerous passages, suggesting telomerase-independent mechanisms responding for telomere maintenance. However, the underlying mechanisms ensuring the telomere length maintenance are unclear. Here, using late generation telomerase KO (G4 Terc-/-) ESCs as a model, we show that Zscan4, highly upregulated in G4 Terc-/- ESCs, is responsible for the prolonged culture of these cells with stably short telomeres. Mechanistically, G4 Terc-/- ESCs showed reduced levels of DNA methylation and H3K9me3 at Zscan4 promoter and subtelomeres, which relieved the expression of Zscan4. Similarly, human ZSCAN4 was also derepressed by reduced H3K9me3 at its promoter in ALT U2 OS cells, and depletion of ZSCAN4 significantly shortened telomeres. Our results define a similar conserved pathway contributing to the telomere maintenance in telomerase-deficient late generation mESCs and human ALT U2OS cancer cells.
Effect of Withanolide A on 7-Ketocholesterol Induced Cytotoxicity in hCMEC/D3 Brain Endothelial Cells
Authors: Soh Sandra , Ong Wei-Yi
Published: January 2022

Withanolide A is a naturally occurring phytochemical that is found in Ashwagandha (Withania somnifera, fam. Solanaceae) or Indian Ginseng. In the current study, we elucidated the effect of withanolide A on 7-ketocholesterol (7KC) induced injury in hCMEC/D3 human brain endothelial cells. 7KC is a cholesterol oxidation product or oxysterol that is present in atherosclerotic plaques and is elevated in the plasma of patients with hypercholesterolemia and/or diabetes mellitus. Results showed that withanolide A significantly reduced the effects of 7KC, which include loss of endothelial cell viability, increase in expression of pro-inflammatory genes-IL-1β, IL-6, IL-8, TNF-α, cyclooxygenase-2 (COX-2), increased COX-2 enzyme activity, increased ROS formation, increased expression of inducible nitric oxide synthase and genes associated with blood clotting, including Factor 2/thrombin, Factor 8, von Willebrand factor, and thromboxane A synthase, and increased human thrombin enzyme activity. Some of the above effects of withanolide A on 7KC were reduced in the presence of the glucocorticoid receptor antagonist, mifepristone (RU486). These findings suggest that the glucocorticoid receptor could play a role in the cytoprotective, antioxidant, and anti-clotting effects of withanolide A against 7KC. Further studies are necessary to elucidate the detailed mechanisms of action of withanolide A against oxysterol-induced injury.
Interfacial Reactions between Si and SiO2 with Ceramic Additives
Authors: Chen Yu-Hsiang , Lin Kun-Lin , Lin Chien-Cheng
Published: January 2022

In this study, 10 wt.% ceramics—Al2O3, La2O3, Y2O3, MgO, and TiO2—were employed as additives for amorphous SiO2 after pressing and annealing at 1300 °C. The amorphous SiO2 changed to cristobalite SiO2. Through X-ray diffraction, scanning electron microscopy, and transmission electron microscopy with energy-dispersive spectrometry, the reaction phases of La2Si2O7, Y2Si2O7, and MgSiO3 (Mg2SiO4) were found in the SiO2 with 10 wt.% La2O3, Y2O3, and MgO additives. Cracks formed in the Si and SiO2–ceramic additive sites because of the difference in the coefficients of thermal expansion among the Si, SiO2, ceramic additives, and reaction phases. After Si came into contact with the SiO2–ceramics, two types of microstructures were found: those with and those without an amorphous SiO2 reaction layer at the interface. Amorphous SiO2 layer formation is due to the replacement of the Si position in SiO2 by Al3+ and Ti4+ impurities, which can break the bonds between Si atoms. The O content in the Si decreased from 6–9 × 1017 atoms/cm3 for SiO2 to less than ~1016 for SiO2–Al2O3 and SiO2–MgO. The average resistivity of the Si was 3 Ω·cm for SiO2 and decreased to 0.12–0.36 Ω·cm for the SiO2 with ceramic additives.
A New Method for Enantiomeric Determination of 3,4-Methylenedioxymethamphetamine and p-Methoxymethamphetamine in Human Urine
Authors: Chen Wei-Jay , Wu Ren-Jang , Yang Hsueh-Hui , Lua Ahai-Chang , Tzeng Yin-Jeh , Tuan Shun-Hsing , Chen Liang , Chou Tsong-Yung
Published: January 2022

The abuse of paramethoxymethamphetamine (PMMA) and 3,4-methylenedioxymethamphetamine (MDMA) among young people is increasingly serious and has become a public health problem. Since enantiomers of MDMA and PMMA are metabolized at different rates in the body and exhibit different neurotoxicity in tissues, we have developed a simple method for simultaneous enantiomeric determination of PMMA and MDMA, using parallel dual capillary immunoaffinity columns coupled with tandem mass spectrometry. Linear calibration curves were obtained in concentration ranges of 100–1000 ng/mL, with a limit of quantitation of <22 ng/mL. Good interday accuracy and precision were achieved with this method. Besides filtering the urine sample through a 0.45 μm MILLIPORE membrane, no other sample pretreatment was needed, and no toxic organic solvent was used. It is a rapid, environmentally friendly safe method, and could be applied for routine enantiomeric analysis of PMMA and MDMA in the pharmaceutical industry, forensic science, and environmental analysis.
Long-Term Evolution of the Hip and Proximal Femur after Hip Reconstruction in Non-Ambulatory Children with Cerebral Palsy: A Retrospective Radiographic Review
Authors: Ma Norine , Tischhauser Peter , Camathias Carlo , Brunner Reinald , Rutz Erich
Published: January 2022

Background: Hip displacement in children with cerebral palsy (CP) has a higher prevalence in non-ambulatory children. Progression can lead to pain, pelvic obliquity and difficulty with sitting. This can be addressed with hip reconstruction. Our study aims to report the long-term radiological outcomes after hip reconstruction, in particular the evolution of femoral head deformity. Methods: A total of 58 hips of non-ambulatory children with CP were evaluated retrospectively using pre-operative, early (median 120 days) and late post-operative (median 8.6 years) anteroposterior standardised radiographs. All the hips were treated with femoral shortening varus derotation osteotomy (VDRO), pelvic osteotomy and an open reduction, if indicated. The radiographical indices measured included the migration percentage (MP), sharp angle, acetabular index, centre-edge angle, neck shaft angle, head shaft angle, pelvic obliquity, femoral head sphericity, femoral head deformity (FHD) and growth plate orientation. Results: Improvements in hip congruency and morphology were evident after reconstructive hip surgery. These were maintained at the late post-operative time point. Median MP improved from 56% (IQR 46–85%) to 0% (IQR 0–15%) at early follow-up. This increased to 12% (IQR 0–20%) at late follow-up. Pre-operatively, FHDs of 14 hips (24%) were classified as grade A (spherical femoral head). This increased to 22 hips (38%) at early follow-up and increased further to 44 hips (76%) at late follow-up. Conclusions: Our study shows that hip reconstruction reduces hip displacement in the long term, indicated by decreased post-operative MP maintained at long-term follow-up. Although non-ambulatory children lack weight-bearing forces promoting bone remodelling, improved femoral head morphology after surgery alters the forces between the acetabulum and the femoral head. Mild femoral head deformity (grades A and B) remained stable and even improved after surgery, postulated to be due to severe osteoporosis allowing remodelling.
Tracheal Length Measurement in Intubated Neonates to Guide the Design and Use of Endotracheal Tube Glottic Depth Markings
Authors: Cerone Jennifer B. , Pinheiro Joaquim M. B.
Published: January 2022

Background: Data on neonatal tracheal length are needed to inform the standardization of safety features for endotracheal tubes (ETTs) such as glottic depth markings. Laryngotracheal airway measurements are available from digital imaging in infants and children but not in neonates. We aimed to determine the tracheal length (TL) of intubated preterm and term neonates. Methods: An observational study was performed on 57 neonates of 22–42 weeks’ gestation and <1 week of age. Two clinicians independently reviewed 153 digital chest radiographs to determine the carina position and TL. TL was measured from carina to mid-C4 (cricoid level). We analyzed interrater agreement (within 0.5 vertebral levels) on the position of the carina and TL. TL was plotted as a function of gestational age and weight, using graphical and regression analyses. Results: Carina position ranged from T3 to T5.5, with an interrater agreement of 95%. On image pairs concordant for carina position, TL determinations were virtually identical between readers (mean difference 0.1 mm, 95% CI −0.5–0.6 mm). Average mid-tracheal length overlies the body of T1. In infants aged less than 32 weeks’ gestation, the mid-trachea lies <20 mm from the carina or the larynx. TL linearly correlates with gestational age, but correlation with birthweight best fits a segmented regression with a node at 1 kg. Conclusions: The functional length of the laryngotracheal airway can be reliably measured in sick neonates. It correlates well with gestational age and birthweight, and this information can inform the redesign of ETT markings to promote the safer use of these devices.
Establishment of the First Comprehensive Adult and Pediatric Hematopoietic Stem Cell Transplant Unit in the United Arab Emirates: Rising to the Challenge
Authors: Al-Shamsi Humaid O. , Abyad Amin , Kaloyannidis Panayotis , El-Saddik Amro , Alrustamani Ahmad , Abu Gheida Ibrahim , Ziade Azzam , Dreier Norbert W. , Ul-Haq Urfan , Joshua Thanda Lucy Ann , El Kinge Abdul Rahman , Coelho Ritika , Ibrahim Dima , Afrit Mehdi , Al-Lababidi Bilal , Aabideen Zainul , Sabhani Mayur , Shah Rakeshkumar , Makhlouf Ghaith , Iskandaerani Lana , Iqbal Faryal , Narayanan Shiny , Ameen Mohammed , Morrison Theresa , Khalil Charbel , Mheidly Kayane
Published: January 2022

Hematopoietic stem cell transplantation (HSCT) is increasingly indicated for various malignant and non-malignant diseases. In the United Arab Emirates (UAE), patients that could benefit from the procedure commonly need to seek medical care abroad in view of the lack of a comprehensive HSCT facility that could offer the full spectrum of interventions and monitoring protocols. This comes with considerable challenges related to coverage and logistics of travel. It also limits the continuity of clinical care, and presents inconvenience to patients who come from a different cultural background. In this article, we share our experiences and lessons learned during the establishment of the first comprehensive adult and pediatric HSCT unit in the UAE that is designed to cater for local citizens and residents, as well as neighboring countries facing similar availability challenges.
Dream Recall/Affect and Cortisol: An Exploratory Study
Authors: Triantafyllou Alexandros S. , Ilias Ioannis , Economou Nicholas-Tiberio , Pappa Athina , Koukkou Eftychia , Steiropoulos Paschalis
Published: January 2022

The effect of cortisol on dreams has been scarcely studied. The aim of this exploratory study was to assess the possible effect of cortisol levels on dream recall/affect, considering, in female subjects, their menstrual cycle phase. Fifteen men and fifteen women were recruited. Saliva samples were used for the detection of cortisol levels. Participants were instructed to provide four saliva samples, during three consecutive days. After awakening, on the second and third day, they were asked whether they could recall the previous night’s dreams and whether these were pleasant or unpleasant. Female subjects followed this procedure twice: firstly, during the luteal phase and, secondly, during the follicular phase of the menstrual cycle. Subjects with higher evening or higher morning cortisol levels tended to show increased dream recall; a non-statistically significant association between morning cortisol levels and positive dream affect was also found. This association acquired statistical significance for salivary morning cortisol levels exceeding the upper normal level of 19.1 nmol/L (OR: 4.444, 95% CI: 1.108–17.830, p-value: 0.039). No connection between menstrual cycle stages and dream recall/affect was detected. In conclusion, cortisol may be a crucial neuromodulator, affecting dream recall and content. Therefore, its effects on sleep and dreams should be further studied.
The Effect of Annealing Temperature on the Microstructure and Properties of Cr–C–Al Coatings on Zircaloy-4 for Accident-Tolerant Fuel (ATF) Applications
Authors: Tang Chongchong , Steinbrück Martin , Grosse Mirco , Ulrich Sven , Stüber Michael
Published: January 2022

Elemental Cr/C/Al multilayers (stoichiometric ratio: 2:1:1) with and without a Cr overlayer have been synthesized on Zircaloy-4 substrates by magnetron sputtering. The effects of annealing temperatures (400 and 550 °C) on phase/microstructure formation, mechanical properties, and oxidation/corrosion performance have been comparatively studied. Annealing of the multilayers at 400 °C led to the formation of nanocrystalline composite consisting of intermetallic and binary carbide phases. Single-phase Cr2AlC was obtained after 550 °C annealing, but with microcracking of the coatings. Both annealed coatings displayed similar mechanical properties, high-temperature oxidation, and hydrothermal corrosion mechanisms. The composite coatings annealed at 400 °C significantly enhance the high-temperature oxidation resistance (α-Al2O3 scale growth) and hydrothermal corrosion (Cr2O3 passivation layer formation) of a Zircaloy-4 substrate without coating microcracking and delamination. Nanocomposite CrCAl-based coatings are promising candidates for coated ATF applications with acceptable processing temperatures and excellent oxidation/corrosion resistances for a zirconium alloy substrate.
Optimization and Antibacterial Response of N-Halamine Coatings Based on Polydopamine
Authors: Nazi Nadia , Marguier Adeline , Debiemme-Chouvy Catherine , Humblot Vincent
Published: January 2022

Due to the ability of microorganisms to first adhere to a material surface and then to lead to the formation of a biofilm, it is essential to develop surfaces that have antimicrobial properties. It is well known that N-halamine coatings allow us to prevent or minimize such phenomena. In the present work, various polydopamine (PDA) coatings containing chloramine functions were studied. In fact, three PDA-based films were formed by the simple immersion of a gold substrate in a dopamine solution, either at pH 8 in the presence or not of polyethyleneimine (PEI), or at pH 5 in the presence of periodate as an oxidant. These films were characterized by polarization modulation reflection absorption infrared spectroscopy and X-ray photoelectron spectroscopy analyses, and by scanning electron microscopy observations. The chlorination of these PDA films was performed by their immersion in a sodium hypochlorite aqueous solution, in order to immobilize Cl(+I) into the (co)polymers (PDA or PDA–PEI). Finally, antibacterial assays towards the Gram-negative bacteria Escherichia coli (E. coli) and the Gram-positive bacteria Staphylococcus epidermidis (S. epidermidis) were conducted to compare the bactericidal properties of these three N-halamine coatings. Regardless of the bacteria tested, the PDA coating with the best antibacterial properties is the coating obtained using periodate.
Finite Mixture Models for Clustering Auto-Correlated Sales Series Data Influenced by Promotions
Authors: Pacella Massimo , Papadia Gabriele
Published: January 2022

The focus of the present paper is on clustering, namely the problem of finding distinct groups in a dataset so that each group consists of similar observations. We consider the finite mixtures of regression models, given their flexibility in modeling heterogeneous time series. Our study aims to implement a novel approach, which fits mixture models based on the spline and polynomial regression in the case of auto-correlated data, to cluster time series in an unsupervised machine learning framework. Given the assumption of auto-correlated data and the usage of exogenous variables in the mixture model, the usual approach of estimating the maximum likelihood parameters using the Expectation–Maximization (EM) algorithm is computationally prohibitive. Therefore, we provide a novel algorithm for model fitting combining auto-correlated observations with spline and polynomial regression. The case study of this paper consists of the task of clustering the time series of sales data influenced by promotional campaigns. We demonstrate the effectiveness of our method in a case study of 131 sales series data from a real-world company. Numerical outcomes demonstrate the efficacy of the proposed method for clustering auto-correlated time series. Despite the specific case study of this paper, the proposed method can be used in several real-world application fields.
Quantum Reservoir Computing for Speckle Disorder Potentials
Authors: Mujal Pere
Published: January 2022

Quantum reservoir computing is a machine learning approach designed to exploit the dynamics of quantum systems with memory to process information. As an advantage, it presents the possibility to benefit from the quantum resources provided by the reservoir combined with a simple and fast training strategy. In this work, this technique is introduced with a quantum reservoir of spins and it is applied to find the ground state energy of an additional quantum system. The quantum reservoir computer is trained with a linear model to predict the lowest energy of a particle in the presence of different speckle disorder potentials. The performance of the task is analyzed with a focus on the observable quantities extracted from the reservoir and it is shown to be enhanced when two-qubit correlations are employed.
Food Loss and Food Waste for Green Cosmetics and Medical Devices for a Cleaner Planet
Authors: Morganti Pierfrancesco , Gao Xinghua , Vukovic Natalia , Gagliardini Alessandro , Lohani Alka , Morganti Gianluca
Published: January 2022

To stay wealthy in a world where all can live in prosperity and wellbeing, it is necessary to develop sustainable growth at net zero emissions to stop climate change, neutralizing both risks and diseases such as the COVID-19 pandemic and inequalities. Changing the worldwide use of the great quantity of food loss and waste can help to move in this direction. At this purpose, it seems useful to transform food waste into richness, extracting and using its content in natural ingredients and biopolymers to make new sustainable products and goods, including cosmetics and medical devices. Many of these ingredients are not only bioactive molecules considered of interest to produce these consumer products but are also useful in reducing the environmental footprint. The active agents may be obtained, for example, from waste material such as grapes or olive pomace, which include, among others natural polymers, phythosterols, vitamins, minerals and unsaturated fatty acids. Among the polymers, chitin and lignin have shown particular interest because biodegradable, nontoxic, skin- and environmentally friendly ingredients can be obtained at low cost from food and forestry waste, respectively. According to our experience, these polymers may be used to make nanocomposites and micro-nanoparticles that encapsulate different active ingredients, and which may be embedded into gel and non-woven tissues to realize advanced medications and smart cosmeceuticals. However, to utilize food waste in the best possible way, a better education of both industry and the consumer is considered necessary, introducing all to change the ways of production and living. The consumer has to understand the need to privilege, food, cosmetics and goods by selecting products known to be effective that also have a low release of carbon dioxide. Thus, they must pay heed to purchasing cosmetics and medical devices made by natural ingredients and packaged by biodegradable and/or reusable containers that are possibly plastic free. Conversely, the industry must try to use natural raw materials obtained from waste by changing their actual production methods. Therefore, both industry and the consumer should depart from the linear economy, which is based on taking, making, and producing waste, to move into a circular economy, which is based on redesigning, reducing, reusing and recycling. Some examples will report on the possibility to use natural polymers, including chitin and lignin, to produce new cosmeceutical tissues. These innovative tissues, to be used as biodegradable carriers for making smart cosmetics and medical devices, may be produced at zero waste to save our health and the planet biodiversity.
Outcomes of Enhanced Recovery after Surgery (ERAS) in Gynecologic Oncology: A Review
Authors: Bisch Steven P. , Nelson Gregg
Published: January 2022

Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement program that started in colorectal surgery and has now expanded to numerous specialties, including gynecologic oncology. ERAS guidelines comprise multidisciplinary, evidence-based recommendations in the preoperative, intraoperative, and postoperative period; these interventions broadly encompass patient education, anesthetic choice, multimodal pain control, avoidance of unnecessary drains, maintenance of nutrition, and prevention of emesis. Implementation of ERAS has been shown to be associated with improved clinical outcomes (length of hospital stay, complications, readmissions) and cost. Marx and colleagues first demonstrated the feasibility of ERAS in gynecologic oncology in 2003; since then, over 30 comparative studies and 4 guidelines have been published encompassing major gynecologic surgery, cytoreductive surgery, and vulvar/vaginal surgery. Implementation of ERAS in gynecologic oncology has been demonstrated to provide improvements in length of stay, complications, cost, opioid use, and patient satisfaction. Increased compliance with ERAS guidelines has been associated with greater improvement in outcomes.
Is Diversity the Missing Link in Coastal Fisheries Management?
Authors: Kininmonth Stuart , Blenckner Thorsten , Niiranen Susa , Watson James , Orio Alessandro , Casini Michele , Neuenfeldt Stefan , Bartolino Valerio , Hansson Martin
Published: January 2022

Fisheries management has historically focused on the population elasticity of target fish based primarily on demographic modeling, with the key assumptions of stability in environmental conditions and static trophic relationships. The predictive capacity of this fisheries framework is poor, especially in closed systems where the benthic diversity and boundary effects are important and the stock levels are low. Here, we present a probabilistic model that couples key fish populations with a complex suite of trophic, environmental, and geomorphological factors. Using 41 years of observations we model the changes in eastern Baltic cod (Gadus morhua), herring (Clupea harengus), and Baltic sprat (Sprattus sprattus balticus) for the Baltic Sea within a Bayesian network. The model predictions are spatially explicit and show the changes of the central Baltic Sea from cod- to sprat-dominated ecology over the 41 years. This also highlights how the years 2004 to 2014 deviate in terms of the typical cod–environment relationship, with environmental factors such as salinity being less influential on cod population abundance than in previous periods. The role of macrozoobenthos abundance, biotopic rugosity, and flatfish biomass showed an increased influence in predicting cod biomass in the last decade of the study. Fisheries management that is able to accommodate shifting ecological and environmental conditions relevant to biotopic information will be more effective and realistic. Non-stationary modelling for all of the homogeneous biotope regions, while acknowledging that each has a specific ecology relevant to understanding the fish population dynamics, is essential for fisheries science and sustainable management of fish stocks.
Major Ion Toxicity to Glochidia of Common and Imperiled Freshwater Mussel Species
Authors: Bringolf Robert B. , Raines Brenna K. , Ratajczak Robert E. , Haskins David Lee
Published: January 2022

Freshwater mussel taxa are severely imperiled and among the most sensitive to several contaminants, including chloride. Relatively little is known of the toxicity of major ions to glochidia (larvae), particularly for rare species, or the effects of hardness on major ion toxicity to glochidia. Therefore, the primary objectives of this work were to: (1) determine the acute toxicity of major ion salts to glochidia, (2) compare chloride sensitivity of glochidia from common and rare species, and (3) evaluate the relationship between water hardness and chloride toxicity to glochidia. We assessed 24 h EC50s for fatmucket (Lampsilis siliquoidea) glochidia exposed to NaCl, KCl, MgCl2, CaCl2, Na2SO4, MgSO4, CaSO4, and NaHCO3 in moderately hard water. We determined NaCl EC50s for four species and KCl EC50s for glochidia of three species. Toxicity of chloride was generally consistent among the various chloride salts except for KCl, which was more toxic than all others by 1–2 orders of magnitude. Our results suggest that commonly tested species may be generally representative of rare species. Water hardness ameliorated the toxicity of chloride for all species to varying degrees. Results of this work indicate that some existing water quality criteria that do not include mussel toxicity data may not be protective of freshwater mussels.
A Multi-Part Production Planning Framework for Additive Manufacturing of Unrelated Parallel Fused Filament Fabrication 3D Printers
Authors: Cadiou Thibaut , Demoly Frédéric , Gomes Samuel
Published: January 2022

Fostering the development of additive manufacturing (AM) in the context of mass production is a key factor to ensure its adoption in the industry. It should be remembered that this technology intrinsically makes it possible to produce parts with unexpected complexities in terms of shape and structure, but this comes at a price: time. To overcome this productivity barrier, AM technology providers are developing 3D printing machines with high-speed performance and mass reproduction means in a single run. Although such trends can be seen as a natural evolution of this technology with respect to current consumption patterns, it still remains a scientific issue on production planning to be tackled. The objective is to address the on-demand production planning of different AM parts in FabLabs composed of unrelated parallel 3D printers. A novel framework is introduced to consider part orientation, path planning, and part-to-printer assignment, with a specific focus on fused filament fabrication technique. By targeting a minimum production time, it exhibits reasoning algorithms implemented in a Python application. A case study with a batch of six non-identical parts and two fused filament fabrication 3D printers is introduced to illustrate the added value of the framework and its operational side.
Analysis of Early Biomarkers Associated with the Development of Critical Respiratory Failure in Coronavirus Disease 2019 (COVID-19)
Authors: Yamada Hiroyoshi , Okamoto Masaki , Nagasaki Yoji , Yoshio Suzuyo , Nouno Takashi , Yano Chiyo , Tanaka Tomohiro , Watanabe Fumi , Shibata Natsuko , Arimizu Yoko , Fukamachi Yukako , Zaizen Yoshiaki , Hamada Naoki , Kawaguchi Atsushi , Hoshino Tomoaki , Morita Shigeki
Published: January 2022

Certain biomarkers predict death due to acute respiratory distress syndrome in COVID-19 patients. We retrospectively analyzed biomarkers associated with time to mechanical ventilation for respiratory failure due to COVID-19 (time-to-mechanical ventilation) in 135 consecutive patients in our hospital. We analyzed biomarkers that were elevated immediately (at admission) and later (3 days after admission) using Cox proportional hazards regression analysis. Independent biomarkers of time-to-mechanical ventilation were high C-reactive protein (CRP), interleukin (IL)-6, and Krebs von den Lungen-6 (KL-6) concentrations at admission and elevated CRP, high-mobility group box-1 protein (HMGB-1), and d-dimer levels and low platelets 3 days after admission. Receiver operating characteristic analysis for detecting the association between independent biomarkers associated with time-to-event in multivariate analyses and the start of mechanical ventilation revealed that these biomarkers had area under the curve values higher than 0.700. The present study suggests that CRP was the only biomarker associated with time-to-mechanical ventilation both at admission and 3 days after admission. Moreover, IL-6 (an inflammatory cytokine), HMGB-1 (a late inflammatory mediator), and KL-6 (reflecting injury and/or remodeling of type II pneumocytes) were associated with outcomes in COVID-19 as reported previously. In conclusion, increased CRP, IL-6, KL-6, HMGB-1, and d-dimer levels and decreased platelet counts were associated with the start of mechanical ventilation due to COVID-19.
Polygenetic Variants Related to Osteoarthritis Risk and Their Interactions with Energy, Protein, Fat, and Alcohol Intake in Adults in a Large Cohort
Authors: Park Sunmin
Published: January 2022

Osteoarthritis (OA) is increasing globally, especially among elderly Asian women, and its increase may be due to the interaction between genetic factors and lifestyle. This study tested the hypothesis that polygenetic variants associated with OA risk interacted with lifestyle in adults over 40 years in the Ansan–Ansung cohort. Genetic variants were chosen through a genome-wide association study with OA participants (case; n = 580) and controls without arthritis (n = 4850). Genetic variants with interactions were selected by a generalized multifactor dimensionality reduction. The best model’s polygenic risk scores (PRS) were calculated by summing the number of risk alleles in the selected genetic variants. The best five single nucleotide polymorphism (SNP) model included AIG1_rs6570550, COX10_rs62054459, DLG2_rs148643344, SOX5_rs73283615, and PLXNA4_rs1472529430, while IL12A_ rs1491318751 was added to the five-SNP model to produce a six-SNP model. Only COX10_rs62054459 in subcutaneous and visceral adipose tissue was associated with COX10 protein expression. The participants, having high-PRS from the five-SNP and six-SNP models, were at a higher OA risk than those with low-PRS by 3.88 and 4.42 times, respectively. The PRS was not associated with metabolic syndrome or with the insulin resistance index (HOMA-IR). Energy, protein, fat, alcohol, and a Western-style diet intake interacted with the PRS to influence OA risk (p = 0.005, 0.042, and 0.021, respectively). In the high energy and alcohol intake and low protein, fat, Western-style diet intake, the participants with a high-PRS had a higher incidence of OA than those with low-PRS. In conclusion, the adults with a high-PRS were at a higher OA risk. Particularly, adults with high PRS should have a lower energy intake, higher WSD containing higher protein and fat intake, and moderate alcohol intake to alleviate OA risk. These results can be applied to personalized nutrition plans to decrease OA risk.
Detection of Cause-Effect Relations Based on Information Granulation and Transfer Entropy
Authors: Zhang Xiangxiang , Hu Wenkai , Yang Fan
Published: January 2022

Causality inference is a process to infer Cause-Effect relations between variables in, typically, complex systems, and it is commonly used for root cause analysis in large-scale process industries. Transfer entropy (TE), as a non-parametric causality inference method, is an effective method to detect Cause-Effect relations in both linear and nonlinear processes. However, a major drawback of transfer entropy lies in the high computational complexity, which hinders its real application, especially in systems that have high requirements for real-time estimation. Motivated by such a problem, this study proposes an improved method for causality inference based on transfer entropy and information granulation. The calculation of transfer entropy is improved with a new framework that integrates the information granulation as a critical preceding step; moreover, a window-length determination method is proposed based on delay estimation, so as to conduct appropriate data compression using information granulation. The effectiveness of the proposed method is demonstrated by both a numerical example and an industrial case, with a two-tank simulation model. As shown by the results, the proposed method can reduce the computational complexity significantly while holding a strong capability for accurate casuality detection.
An Attack Simulation and Evidence Chains Generation Model for Critical Information Infrastructures
Authors: Kalogeraki Eleni-Maria , Papastergiou Spyridon , Panayiotopoulos Themis
Published: January 2022

Recently, the rapid growth of technology and the increased teleworking due to the COVID-19 outbreak have motivated cyber attackers to advance their skills and develop new sophisticated methods, e.g., Advanced Persistent Threat (APT) attacks, to leverage their cybercriminal capabilities. They compromise interconnected Critical Information Infrastructures (CIIs) (e.g., Supervisory Control and Data Acquisition (SCADA) systems) by exploiting a series of vulnerabilities and launching multiple attacks. In this context, industry players need to increase their knowledge on the security of the CIs they operate and further explore the technical aspects of cyber-attacks, e.g., attack’s course, vulnerabilities exploitability, attacker’s behavior, and location. Several research papers address vulnerability chain discovery techniques. Nevertheless, most of them do not focus on developing attack graphs based on incident analysis. This paper proposes an attack simulation and evidence chains generation model which computes all possible attack paths associated with specific, confirmed security events. The model considers various attack patterns through simulation experiments to estimate how an attacker has moved inside an organization to perform an intrusion. It analyzes artifacts, e.g., Indicators of Compomise (IoCs), and any other incident-related information from various sources, e.g., log files, which are evidence of cyber-attacks on a system or network.
Sizing the Thermal Energy Storage Device Utilizing Phase Change Material (PCM) for Low-Temperature Organic Rankine Cycle Systems Employing Selected Hydrocarbons
Authors: Daniarta Sindu , Nemś Magdalena , Kolasiński Piotr , Pomorski Michał
Published: January 2022

Thermal energy storage (TES) looks to be a promising technology for recovering waste heat or other intermittent heat sources, especially if it is coupled with the organic Rankine cycle (ORC) system. This system may use a variety of heat storage materials, including solids, liquids, and phase change materials (PCM). This article discusses the use of PCM as a thermal energy storage material in TES systems coupled with ORC systems. Other TES configurations may be used in ORC; however, in this article, the TES is solely used in heat exchangers, i.e., evaporator and liquid heater. The goal of this research is to establish a dimensionless storage mass parameter for sizing TES-evaporator (TES-EVA) or TES-liquid heater (TES-LH) devices for ORCs. Furthermore, the model of this system was created in the MATLAB environment using the chosen hydrocarbons as ORC working fluids. The obtained modelling results provide a novel point of view that scientists and engineers may employ while developing the TES-EVA or TES-LH utilizing PCM for ORC.
Measuring the Efficiency of Energy and Carbon Emissions: A Review of Definitions, Models, and Input-Output Variables
Authors: Li Shuangjie , Wang Wei , Diao Hongyu , Wang Liming
Published: January 2022

The importance and urgency of improving energy and carbon emissions efficiency in mitigating climate change and achieving carbon neutrality have become an increasingly relentless focus in recent years. Assessing the performance of energy saving and carbon emissions reduction is a significant necessity to achieve sustainable economic development. Therefore, from the perspective of production economics, this paper presents a review of the definition, models, and input-output variables for measuring total-factor energy efficiency and total-factor carbon emissions efficiency. Relevant literature in this field, published between 2006 and 2021, has been systematically analyzed using CiteSpace software, which includes a quantitative and visual review of a large body of published literature. This review found that the current definitions of total-factor energy efficiency and total-factor carbon emissions efficiency are confusing and misleading. Furthermore, future research on energy saving and carbon emissions reduction should incorporate subject areas such as economics, energy, and ecology.
Comment on Seibert, M.K.; Rees, W.E. Through the Eye of a Needle: An Eco-Heterodox Perspective on the Renewable Energy Transition. Energies 2021, 14, 4508
Authors: Diesendorf Mark
Published: January 2022

The ‘review’ by Seibert and Rees [...]
Hydrate-Based Separation for Industrial Gas Mixtures
Authors: Khan Muhammad , Warrier Pramod , Peters Cornelis , Koh Carolyn
Published: January 2022

The removal of acidic gases and impurities from gas mixtures is a critical operation in the oil and gas industry. Several separation techniques, e.g., cryogenic fractionation, polymeric membranes, zeolites, and metal–organic frameworks, are employed to treat gas mixtures depending upon the nature of separation and contaminants present in the gas mixtures. However, removing N2, H2, H2S, and CO2 contents from industrial gas mixtures is a challenging step due to economic factors, high energy consumption, and effective separation. Hydrate-based separation for selective gas removal is a promising and efficient separation technique over a range of temperatures, pressures, and acidic gas contents. The enclathration of CO2, H2, N2, H2S, and other natural gas constituents effectively removes acidic gases and other contaminants from process gas streams. This work presents a novel process design to remove acidic gases and other contaminants from industrial waste gases and natural gas mixtures to achieve the desired selectivity in gas mixtures. Multi-phase equilibria calculations were also performed for various binary and ternary gas mixtures (e.g., CO2 + CH4, H2S + CH4, CO2 + N2, CH4 + CO2 + H2S, and CO2 + H2S + N2) over a range of compositions and T, P conditions. The former calculations established the suitable region in terms of temperature and pressure for adequate separations. To determine the optimal process conditions (T & P) for efficient separation, fractional cage occupancy and gas mole fraction in each phase were also computed. A detailed analysis of the hydrate-based separation shows that the number of stages necessary for desired separation efficiency depends on the nature of the gas mixture and hydrate stability.