bluuebunny/crossref_metadata_2025 huggingface dataset:
About Activity Of Law-Enforcement Bodies On Preventive Maintenance Of Offences Among Earlier Offenders Of Persons
Authors:   The Teacher Of Chair Of Preventive Maintenance Of Offences Of Academy Of The Ministry Of Internal Affairs Of Republic Uzbekistan, Rayimov Sherzod Tаshtemirovich
Published: March 2021

In article activity of law-enforcement bodies on preventive maintenance of offences among earlier offenders of persons is considered, the special attention is turned on essence of preventive measures spent by inspectors of preventive maintenance in the given sphere.
The Usage Of An Audio-Linguistic Method Of Learning English As A Foreign Language By Intermediate Students
Authors:   Department Of English Language And Literature, Faculty Of Foreign Languages, Kokand State Pedagogical Institute, Kokand, Uzbekistan, Qizi Fazilatkhon Ikromova Vohidjon , Valiyevna Qarshiyeva Shakhnoza ,   Department Of Mathematics And Informatics, Faculty Of Physics And Mathematics, Kokand State Pedagogical Institute, Kokand, Uzbekistan
Published: March 2021

This article describes the aspects of audio- lingual method of language learning. As a conclusion, the main advantages of the method, in the case of its application as an integral part of the methodology of teaching English as a foreign language, and disadvantages that may occur in the case of its autonomous or remote use. Thus, we can say that the audio-lingual method will be a weighty addition to the general methodology of teaching English as a foreign language.
About Features Of The Mechanism Of Activity Of Law-Enforcement Bodies On Preventive Maintenance Of Offences Among Earlier Offenders Of Persons
Authors:   The Teacher Of Chair Of Preventive Maintenance Of Offences Of Academy Of The Ministry Of Internal Affairs Of Republic Uzbekistan, Rayimov Sherzod Tаshtemirovich
Published: March 2021

In article questions of the mechanism of activity of law-enforcement bodies on preventive maintenance of offences among earlier offenders of persons are considered, the special attention is turned on the analysis of algorithm of preventive measures spent by inspectors of preventive maintenance in the given sphere.
Intuitive Metaphysical Insights In The Works Of The Painter Bakhodir Jalalov
Authors:   1st Stage Master Of Specialty “Fine Arts And Applied Arts” At Namangan State University, Namangan, Uzbekistan, Mamatkulov Rashidbek Ravshanbekovich
Published: March 2021

This research paper provides an overview of the works of the Uzbek painter Bakhodir Jalalov (Bakhodir Jalal), which reflects all facets of his talent, admiration for the mastery of revival, as well as a tribute to artistic traditions, the embodiment of unique Central Asian motives, and very successful tests in avant-garde.
Organization Of Teaching Mathematics Of Scholar Students In The Conditions Of A Credit - Modular Training System
Authors:   Senior Teacher Of Department Of Methods Of Teaching Mathematics, Faculty Of Mathematics And Informatics, Jizzakh State Pedagogical Institute, Jizzakh City, Uzbekistan, Ernazarova Nazira Hakhberdievna
Published: March 2021

This paper examines the methodology for organizing training in the course of Higher Mathematics in the conditions of a credit - modular training system, the role of intensive control of students 'knowledge, which increases the activity of students in studying the discipline, preparing them for classes and completing tasks in a timely manner, as well as students' independent work. It is possible to improve teaching mathematics through the use of elements of individual, differentiated, problem-solving and programmed teaching. Moreover, a special role is given to the intensive control of students' knowledge, which increases the activity of students in the study of this discipline, their preparation for classes and their timely completion of tasks, as well as their independent work.
Features Of Patriotic Education In Modern Conditions
Authors:   Applicant Department Of Social Sciences Navoi State Pedagogical Institute, Uzbekistan, Sativaldiyev Pulatjon Adizovich
Published: March 2021

This article elaborates on the meaning of patriotism. It is shown that each person is proud of the achievements and culture of his homeland, the desire to protect the interests of the homeland and his people, devotion to their homeland, language, traditions and customs are formed through love for the motherland. Concepts such as the views of scholars on patriotism, types of patriotism, business patriotism are also reflected.
Reflexive Mechanism - As The Main Form Of Controlling Students' Pychological Conditions
Authors:   Base Doctorate Of Bukhara State University, Uzbekistan, Jalolovich Ramazonov Jahongir
Published: March 2021

This article deals with the theoretical and practical issues of the socio-psychological phenomenon of self-government, the reflexive mechanism, the formation of self-government motivation, self-management and improvement, self-control, social psychological features of self-education illuminated.
Efficiency Criteria Of Educational Technologies In Assessing The Professional And Pedagogical Competence Of The Teacher
Authors:   Senior Lecturer, Karshi Institute Of Engineering And Economics, Karshi City, Uzbekistan, Jumaevich Gоfirov Muzaffar
Published: March 2021

The article reveals such a component of the teacher's professional and pedagogical competence as his mastery of innovative technologies, which are the mechanism in the teacher's activities that ensures the real implementation of new pedagogical goals, conceptual ideas, principles, models, systems. In this case, the criteria for the effectiveness of the educational technologies used by the teacher can serve as indicators of his professional and pedagogical competence.
Goals Of The Russian Empire Against The Invasion In Central Asia
Authors:   Doctor Of Philosophy In History (Phd) Karakalpak State University Named After Berdakh, Uzbekistan, Quatbaevich Jumaniyazov Damir , Kulametovna Toreniyazova Dilfuza ,   Doctoral Studies 1 Course Faculty Of History At Karakalpak State University Named After Berdakh, Uzbekistan, Konysbaevich Berdibekov Muhammed ,   Student Of The Faculty Of History At The Karakalpak State University Named After Berdakh, Uzbekistan
Published: March 2021

Studying history, we see that the political practices and methods of government used by countries have their own characteristics. The article examines the intentions of the Russian Empire to invade Central Asia.
Methodology Of Teaching Assignments To Work With Non-Standard Solution In Primary School Mathematics Education
Authors:   Teacher, Bukhara State University, Uzbekistan, Yunus Yusufzoda Shabnami
Published: March 2021

The content, form of non-standard issues are mentioned in this article. On what subjects such issues are encountered, as well as on the methodology of teaching primary school students to solve non-standard issues.
Intellectual And Cognitive Activities Of School Pupils
Authors:   Lecturer Of Fergana State University, Uzbekistan, Gafurova Makhfuza Abbosovna
Published: March 2021

Some means of stimulating the intellectual and cognitive activity of younger pupils are considered: the creation of interesting educational environment (organization of the pedagogically rational dialogue with the children; using the ways of intellectual and emotional stimulating of the pupils), the use of active teaching methods and form (methods of empathy and figurative vision, didactical games, discussions, conducting of the non standard lessons est.), personality-oriented evaluation of the study-cognitive activity of pupils.
Blood Indications In Echinococcosis Of Large Horned Animals
Authors:   Candidate Of Veterinary Sciences, Senior Research Fellow Veterinary Research Institute, Uzbekistan, Arziev Khidir Yuldashovich , Rasulov Shomurod Makhmudovich ,   Senior Research Fellow Department Of Epidemiology, Tashkent Medical Academy, Uzbekistan, Togaymurodov Mansur Salomatovich ,   Assistant Department Of Zooengineering, Veterinary And Silkworm Breeding Termez Branch Of Tashkent State Agrarian University, Uzbekistan
Published: March 2021

This article presents the results of studying the prevalence of echinococcosis among large horned animals in the Samarkand and Surkhandarya regions and hematological blood parameters in animals heavily or weakly infected with echinococcus in the wild. In Samarkand region, 8.8% of cattle were infected with echinococci, and in Surkhandarya region - 14.3%. Decrease in the amount of erythrocytes and hemoglobin in the blood of cattle infected with echinococcosis (20-30%), increase in the number of leukocytes by 30-55%, and a significant increase in the number of eosinophils and lymphocytes in the leukoform, a decrease in neutrophils compared to control (3.25-6.5%). lymphocytes increased by 5.3-15.3%.
The nanomorphology of cell surfaces of adhered osteoblasts
Authors: Voelkner Christian , Wendt Mirco , Lange Regina , Ulbrich Max , Gruening Martina , Staehlke Susanne , Nebe Barbara , Barke Ingo , Speller Sylvia
Published: March 2021

The functionality of living cells is inherently linked to subunits with dimensions ranging from several micrometers down to the nanometer scale. The cell surface plays a particularly important role. Electric signaling, including information processing, takes place at the membrane, as well as adhesion and contact. For osteoblasts, adhesion and spreading are crucial processes with regard to bone implants. Here we present a comprehensive characterization of the 3D nanomorphology of living, as well as fixed, osteoblastic cells using scanning ion conductance microscopy (SICM), which is a nanoprobing method that largely avoids mechanical perturbations. Dynamic ruffles are observed, manifesting themselves in characteristic membrane protrusions. They contribute to the overall surface corrugation, which we systematically study by introducing the relative 3D excess area as a function of the projected adhesion area. A clear anticorrelation between the two parameters is found upon analysis of ca. 40 different cells on glass and on amine-covered surfaces. At the rim of lamellipodia, characteristic edge heights between 100 and 300 nm are observed. Power spectral densities of membrane fluctuations show frequency-dependent decay exponents with absolute values greater than 2 on living osteoblasts. We discuss the capability of apical membrane features and fluctuation dynamics in aiding the assessment of adhesion and migration properties on a single-cell basis.
Structural Effects of meso-Halogenation on Porphyrins: meso-Xn-ABCD Macrocycles
Authors: Flanagan Keith J , Paradiz Dominguez Maximilian , Melissari Zoi , Eckhardt Hans-Georg , Williams René M , Gibbons Dáire , Prior Caroline , Locke Gemma M , Meindl Alina , Ryan Aoife A , Senge Mathias O
Published: March 2021

The use of halogens in the crystal engineering of porphyrin scaffolds has been a topic of strong interest over the past decades. Previously, this was focused on the introduction of a variety of halogens on the meso-phenyl groups of the porphyrin. However, investigations into the effects of direct halogenation of porphyrins at the meso-position on their crystalline architectures have not been conducted to date. Herein we have characterized a series of direct meso-halogenated porphyrins using single crystal X-ray crystallography. This is accompanied by a detailed conformational analysis of all deposited meso-halogenated porphyrins in the CCDC. In this study we have used the Hirshfeld fingerprint plots together with normal-coordinate structural decomposition and determined crystal structures to elucidate the conformation, present intermolecular interactions, and compare respective contacts within the crystalline architectures. Additionally, we have used density functional theory calculations to determine the structure of several halogenated porphyrins. This contrasts conformational analysis with existing X-ray structures and gives a method to characterize samples that are difficult to crystallize.
El Movimiento Latinoamericano de Video en su cita boliviana
Authors: Aimaretti Maria
Published: March 2021

Como parte de un trabajo más amplio que reconstruye y estudia la serie de instancias de diálogo y eventos regionales que sirvieron al proceso de conformación del Movimiento Latinoamericano de Video, inscrito a su vez en una investigación de largo aliento sobre la producción videográfica boliviana, este artículo se centra en el II Encuentro de la Red que tuvo lugar en junio de 1989 en la ciudad de Cochabamba y que ha sido escasamente examinado. A partir del análisis de documentos, la pesquisa de archivos hemerográficos y un trabajo de historia oral con entrevistas a algunos protagonistas de aquel momento, se repondrá cómo fue su gestación, quiénes intervinieron, cómo se organizaron, qué discusiones sostuvieron y cuáles fueron sus corolarios, a fin de advertir la fisonomía de la reunión y su lugar específico dentro del itinerario diacrónico del Movimiento.
La soledad poblada. El sujeto a través del cine chileno contemporáneo
Authors: García Tayri Paz
Published: March 2021

Ante una sociedad de la fatiga y el imperativo del emprendimiento de la modernidad tardía, pareciera imposible crear lugares y modos de resistencia en los que también atenderse a uno mismo. Esta investigación propone el estudio de la presencia imperante de la soledad en el individuo contemporáneo y cómo es representado en el llamado “novísimo cine chileno”. A través de tres películas, daremos cuenta de este sujeto tardomoderno desasosegado, atravesado por la contradicción y la ambivalencia.
Fisonomía, identidad y alteridad. Hacia una mirada intercultural en Manta Ray
Authors: Martínez Martínez Rodrigo
Published: March 2021

El propósito de este ensayo es analizar tres secuencias de Manta Ray en las que hay un tratamiento fílmico del rostro de los protagonistas que es consistente y que puede relacionarse con el concepto de fisonomía de Béla Balázs, así como con la noción de ética de la alteridad de Emmanuel Lévinas. Este entramado teórico contribuirá a reconocer el significado implícito del filme en relación con su contexto y, sobre todo, la forma en que Phuttiphong Aroonpheng interpretó el problema antropológico del encuentro entre identidad y alteridad más allá del argumento del filme. La descripción de la dialéctica formal, la síntesis del relato y los conceptos sugeridos permitirán entender por qué el abordaje del rostro constituye un motivo fílmico que representa la fisonomía humana como fundamento de una posible mirada intercultural.
El imperio de lo artístico: creación y consumo en la era del capitalismo transestético
Authors: Correa Rivera Eduardo
Published: March 2021

La fase actual del modelo económico global ha estimulado la necesidad de revestir con valores simbólicos toda práctica cotidiana y de consumo. Con ese fin ha extraído del sistema artístico institucional una serie de operaciones, y las ha desplegado a través de toda la cultura material y afectiva, haciendo de nuestro mundo un escenario completamente estetizado y ansioso de la experiencia artística como trasfondo de todos sus hábitos y modos de relación. Ese proceso ha revivido la figura del genio, esta vez como marca registrada, como diseñador o como productor de contenidos digitales. Sin embargo, lejos de significar un declive de la producción artística en función de un aditivo superficial, este horizonte es también una oportunidad para extender la posibilidad de la creación mediante la apropiación de herramientas y circuitos de acceso común.
Transfer of West Indian Marsdenia to Ruehssia (Apocynaceae-Asclepiadoideae)
Authors: Acevedo-Rodríguez Pedro
Published: March 2021

11 species of Marsdenia occurring in the West Indies are transferred to the genus Ruehssia (Apocynaceae–Asclepiadoideae)
Hoya pyrifolia (Apocynaceae), a new species from south-western Yunnan, China
Authors: Huang Er-Feng , Yao Gang , Jiang Ri-Hong , Yang Lei-Lei , Xi Wang , Zhang Zhong-Shuai , Zhang Xian-Chun
Published: March 2021

Hoya pyrifolia, a new species of Apocynaceae from Yunnan Province, China, is described and illustrated. Results from phylogenetic analyses, based on combined DNA fragments of the nuclear ribosomal external transcribed spacer (ETS), intergeneric transcribed spacer (ITS) and three plastid DNA fragments (matK, psbA-trnH and trnT-trnL), showed that the new species was nested within a clade, including Hoya species distributed in the subtropical foothills of the Himalayas and the Tibet-Sichuan Plateau. Morphologically, the new species can be distinguished from its close relatives by its pyriform and slightly pubescent leaves, as well as the 4-flowered inflorescences.
Chroesthes (Acanthaceae) in Peninsular Malaysia, including a new species from Kelantan and a new record from Terengganu
Authors: Yunoh Siti-Munirah Mat
Published: March 2021

Chroesthes is a small genus that includes three species from Peninsular Malaysia: Chroesthes faizaltahiriana Siti-Munirah sp. nov., C. lanceolata (T. Anderson) B.Hansen and C. longifolia (Wight) B.Hansen. Chroesthes faizaltahiriana, recently discovered in the State of Kelantan, is described and illustrated. This species is similar to the common species C. longifolia, but is distinguished mainly by its inflorescence type, calyx shape and its flowers being bright orange instead of dark purple internally. Chroesthes lanceolata is a new record for Peninsular Malaysia and has only been collected once. Following the IUCN Red List Categories and Criteria, these three species are assessed (national scale assessment) as Critically Endangered (C. faizaltahiriana and C. lanceolata) and Least Concern (C. longifolia).
Phylogeny and historical biogeography analysis support Caucasian and Mediterranean centres of origin of key holoparasitic Orobancheae (Orobanchaceae) lineages
Authors: Piwowarczyk Renata , Schneider Adam C. , Góralski Grzegorz , Kwolek Dagmara , Denysenko-Bennett Magdalena , Burda Anna , Ruraż Karolina , Joachimiak Andrzej J. , Pedraja Óscar Sánchez
Published: March 2021

The extensive diversity of the tribe Orobancheae, the most species-rich lineage of holoparasitic Orobanchaceae, is concentrated in the Caucasus and Mediterranean regions of the Old World. This extant diversity has inspired hypotheses that these regions are also centres of origin of its key lineages, however the ability to test hypotheses has been limited by a lack of sampling and phylogenetic information about the species, especially in the Caucasus region. First, we assessed the phylogenetic relationships of several poorly known, problematic, or newly described species and host-races of four genera of Orobancheae occurring in the Caucasus region–Cistanche, Phelypaea, Phelipanche and Orobanche–using nuclear ribosomal (ITS) and plastid (trnL–trnF) sequence data. Then we applied a probablistic dispersal-extinction-cladogenesis model of historical biogeography across a more inclusive clade of holoparasites, to explicitly test hypotheses of Orobancheae diversification and historical biogeography shifts. In sum, we sampled 548 sequences (including 196 newly generated) from 13 genera, 140 species, and 175 taxa across 44 countries. We find that the Western Asia (particularly the Caucasus) and the Mediterranean are the centre of origin for large clades of holoparasitic Orobancheae within the last 6 million years. In the Caucasus, the centres of diversity are composed both of long-branch taxa and shallow, recently diversified clades, while Orobancheae diversity in the Mediterranean appears to represent mainly recent diversification.
Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019
Authors: Kim Ji-Won , Kwak Sang Gyu , Lee Hwajeong , Kim Seong-Kyu , Choe Jung-Yoon , Park Sung-Hoon
Published: March 2021

Background/Aims: The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.Methods: The data were collected from the South Korea National Health Insurance Sharing-COVID-19 database. All individuals who underwent nasopharyngeal and oropharyngeal swab tests for COVID-19 from January 2020 to May 2020 are included. The association between COVID-19 risk and HCQ use was examined in a propensity score-matched population. Factors associated with COVID-19 were identified using multiple logistic regression analysis.Results: Total 8,070 patients with COVID-19 and 121,050 negative controls were included from the database. Among all participants, 381 were HCQ users. In a propensity score-matched population, the incidence of COVID-19 was 7.1% in HCQ users and 6.8% in non-users. The odds ratio (OR) for HCQ use was 1.05 with a 95% confidence interval (CI) of 0.58 to 1.89. Among the subpopulation of patients with rheumatoid arthritis (RA), 33 were diagnosed with COVID-19 and 478 were not. Use of HCQ, glucocorticoids, or other immunosuppressive drugs was not associated with COVID-19 risk, whereas abatacept use was. Chronic lung disease was an independent risk factor for COVID-19 diagnosis in patients with RA (adjusted OR, 6.07; 95% CI, 1.10 to 33.59).Conclusions: The risk of COVID-19 did not differ between HCQ users and non-users. Glucocorticoids, conventional disease-modifying antirheumatic drugs (DMARDs), and biological DMARDs other than abatacept did not increase the risk of COVID-19.
BV solutions of a convex sweeping process with a composed perturbation
Authors: Tolstonogov Alexander
Published: March 2021

A measurable sweeping process with a composed perturbation is considered in a separable Hilbert space. The values of the moving set generating the sweeping process are closed, convex sets. The retraction of the sweeping process is bounded by a positive Radon measure. The perturbation is the sum of two multivalued mappings. The values of the first one are closed, bounded, not necessarily convex sets. It is measurable in the time variable, is Lipschitz continuous in the phase variable, and satisfies a conventional growth condition. The values of the second one are closed, convex, not necessarily bounded sets. We assume that this mapping has a closed with respect to the phase variable graph.

The remaining assumptions concern the intersection of the second mapping and the multivalued mapping defined by the growth conditions. We suppose that this intersection has a measurable selector and has certain compactness properties.

We prove the existence of solutions for our inclusion. The proof is based on the author's theorem on continuous with respect to a parameter selectors passing through fixed points of contraction multivalued maps with closed, nonconvex, decomposable values depending on the parameter, and the classical Ky Fan fixed point theorem. The results which we obtain are new.
Impact of Green Attributes on Revisiting Intentions of Tourists in Sri Lankan Hotels: The Mediating Effect of Overall Satisfaction
Authors: Jayasinghe J. A. S. C. , Weerasekara W. M. T. K.
Published: March 2021

In the Sri Lankan context, the publicly available research has not addressed precisely the relationship between green attributes and revisiting intentions so far. Therefore, this research mainly aimed to study the impact of Sri Lankan hotels’ green attributes on tourists’ revisiting intention. Besides how these said attributes affect overall satisfaction, and mediation role of tourists’ overall satisfaction on revisiting intention was also investigated. The present research is a positivistic study, and a survey was conducted based on a convenience sample selected from foreign and local tourists who had experience in hotels offered green attributes. The data were analyzed by two path models using AMOS 23. Findings show that some of the green attributes positively impact revisiting intentions, and some of the green attributes positively impact overall satisfaction. Furthermore, the overall satisfaction mediates the relationship between organic foods and revisiting, and also the relationship between water-saving attributes and revisiting intentions. These findings will help academics understand the theoretical relationships and for hoteliers to launch innovative and profitable green practices.
Unrealistic Optimism, Compulsive Purchasing and Debt-Stress among Credit Card Users in Sri Lanka
Authors: Rodrigo G. M. R. , Galdolage B. S.
Published: March 2021

Credit cards become increasingly popular in Sri Lanka while a total of 78,201 new issues were in 2019 first quarter (Central Bank report). Credit card usage affects the consumption patterns of people, sometimes leading to purchase excessively with impractical confidence (Omar, et al., 2013). According to the central bank report, around total of 118,905 cards are being defaulted where the payment is in arrears for 90days or more in 2019 showing an increment in credit card debts, which may result in stress among card users. In view of the timeliness and relevance of this issue, this study aims to investigate the impact of unrealistic optimism and compulsive purchasing on debt-stress among credit card users in Sri Lanka. This study employs the quantitative approach in collecting data using self-administered questionnaires among 301 credit cardholders in Western Province, Sri Lanka who were chosen based on the non-probabilistic convenience sampling method. This study found a moderate positive impact of both the unrealistic optimism and compulsive purchasing on debt stress. Further, a moderate positive correlation was found between unrealistic optimism and compulsive purchasing too. This research contributes to fill the gap in the extant literature by broadening the understanding on concepts such as unrealistic optimism, compulsive purchasing, and debt stress which is prevalent among credit card users. Further, as managerial implications, this study provides a better understanding on cardholders in Sri Lanka which might be a good reference for banks, card service providers and investors in developing their policies. Further, it will support the business sector to develop the Sri Lankan non-cash payment market while policymakers and tax authorities can understand the causes of high credit card debts.
Pyroptosis Mediates Neutrophil Extracellular Trap Formation during Bacterial Infection in Zebrafish
Authors: Chen Weijie , Zhao Jingjing , Mu Di , Wang Zhuang , Liu Qin , Zhang Yuanxing , Yang Dahai
Published: March 2021

The formation of neutrophil extracellular trap (NET) is a critical host defense when neutrophils migrate to infection sites. Pyroptosis is a newly identified programmed cell death, which is tightly regulated by inflammasome activation. However, the mechanism of pyroptotic signaling participating in NET production remains to be elucidated. In this study, the zebrafish larvae otic vesicle microinjection model was used to infect larvae with hemolysin-overexpressing Edwardsiella piscicida (EthA+), and a rapid migration of neutrophils to infection sites was observed. Intriguingly, EthA+ infection effectively induced significant neutrophil membrane rupture in vivo, which was dependent on caspase-B (caspy2) and gasdermin Eb (GSDMEb) but not caspase-A or gasdermin Ea. Specifically, the EthA+ E. piscicida infection induced pyroptosis along with NETosis in vitro, and depletion of either caspy2 or GSDMEb impaired NET formation in vivo. Consequently, inhibition of the caspy2–GSDMEb axis-gated NETosis impaired bacterial clearance in vivo. Altogether, these data provide evidence that teleost fish innate immune cells, including neutrophils, express features of pyroptosis that are critical for NETosis in teleost innate immunity.
Screening and Detection of Heterogenous Vancomycin Intermediate Staphylococcus aureus in Hospital Kuala Lumpur Malaysia, Using the Glycopeptide Resistance Detection Etest and Population Analysis Profiling
Authors: Ramli Siti Roszilawati , Neoh Hui-min , Aziz Muhammad Nazri , Hussin Salasawati
Published: March 2021

In a 3-month study done in Hospital Kuala Lumpur (HKL), 7 out of 320 methicillin resistant Staphylococcus aureus isolates were confirmed as heterogeneous vancomycin intermediate S. aureus (hVISA) using the glycopeptide resistance detection e-test and population analysis, giving a prevalence rate of 2.19%. This is the first report of hVISA in Malaysia.
Giornate AIEOP 2010 - Riccione 7 - 9 Novembre 2010
Authors: De Mattia D.
Published: March 2021

Le GIORNATE AIEOP 2010 rinnovano l’incontro di aggiornamento a cadenza annuale riservato agli iscritti all'AIEOP e a chi è impegnato nei Centri di Oncoematologia Pediatrica[...]
Translational relevance of baseline peripheral blood biomarkers to assess the efficacy of anti-programmed cell death 1 use in solid malignancies
Authors: Varayathu Hrishi , Sarathy Vinu , Thomas Beulah Elsa , Mufti Suhail Sayeed , Sangi Lalram , Thungappa Satheesh Chiradoni , Tripathi Priyank , Naik Radheshyam
Published: March 2021

Background:

This study is an overall clinical analysis of anti-programmed cell death 1 (PD1) antibodies used in a single institution, emphasizing the role of baseline peripheral blood markers as a prognostic or predictor biomarker of immunotherapy.

Methods:

Sixty-one patients were retrospectively analyzed from hospital medical records. The endpoint of this study was death from any cause and the survival time was calculated from the date of start of immunotherapy to the date of death. Descriptive and survival statistics was performed using SPSS version 23. Cutoff values for baseline biomarkers (neutrophil-to-lymphocyte ratio [NLR], platelet-to-lymphocyte ratio [PLR], neutrophil-to-eosinophil ratio [NER], and lymphocyte-to-monocyte ratio [LMR]) were obtained using cutp function of Evaluate Cutpoints software (R survMisc package). Pearson and Pearman correlation coefficients were used to examine the relationship of peripheral blood biomarkers.

Results:

Nighty-eight percent of the study population had Stage IV disease and total median overall survival postanti-PD1 therapy was 10.7 months. Patients receiving more than 5 doses of anti-PD1 therapy (12.6 m vs. 4.4 m, P < 0.001) and used in front lines (18.9 m vs. 10.7 m vs. 10.1 m vs. 2.8 m in first line, second line, third line, and >3 lines, respectively, P = 0.049) were found to have an impact in overall survival. Pembrolizumab showed a better survival compared to nivolumab (17.4 m vs. 8.2 m, P = 0.049) in our study. Among baseline biomarkers assessed, NLR (cutoff − 2.81, P = 0.003) and LMR (cutoff – 5.76, P = 0.017) has shown a statistically significant relationship with immunotherapy response. NER (cutoff − 24.32, P = 0.051) and PLR (cutoff – 190.8, P = 0.072) were also found to exhibit a strong relationship with anti-PD1 therapy response. NLR exhibits a statistically significant positive correlation with PLR (r = 0.917 P < 0.001) and NER (r = 0.400 P = 0.014).

Conclusion:

Real-life data analysis of anti-PD1 use for solid cancers highlights that baseline NLR, PLR, NER, and LMR have a significant role as immunotherapy biomarkers. However, larger studies are required to further prove the specificity and sensitivity.
A Lie algebra action on the Chow ring of the Hilbert scheme of points of a K3 surface
Authors: Oberdieck Georg
Published: March 2021

We construct an action of the Neron–Severi part of the Looijenga–Lunts–Verbitsky Lie algebra on the Chow ring of the Hilbert scheme of points on a K3 surface. This yields a simplification of Maulik and Negut’s proof that the cycle class map is injective on the subring generated by divisor classes as conjectured by Beauville. The key step in the construction is an explicit formula for Lefschetz duals in terms of Nakajima operators. Our results also lead to a formula for the monodromy action on Hilbert schemes in terms of Nakajima operators.
Resolvent of the generator of the $C_0$-group with non-basis family of eigenvectors and sharpness of the XYZ theorem
Authors: Sklyar Grigory M. , Marchenko Vitalii
Published: March 2021

The paper presents an explicit form of the resolvent and characterisation of the spectrum for the class of generators of

C_0

-groups with purely imaginary eigenvalues, clustering at

i\infty

, and complete minimal non-basis family of eigenvectors, constructed recently by the authors in [28]. The discrete Hardy inequality serves as the cornerstone for the proofs of the corresponding results. Furthermore, it is shown that the main result on the Riesz basis property for invariant subspaces of the generator of the

C_0

-group (the XYZ theorem), obtained a decade ago by G. Q. Xu, S. P. Yung and H. Zwart in [31] and [32], is sharp.
A model of pilot study to assess the risk of exposure to surgical smokes for operating room personnel
Authors: Frascio Marco , Mascherini Matteo , Batistotti Paola , Cortese Katia , Fornaro Rosario
Published: March 2021

"During the last decades the exposure to surgical smokes has been a long-standing concern both in open and laparoscopic surgery. The aim of this project is to assess the health risks for medical operating room (OR) personnel associated with surgical plumes derived from laparoscopic procedures. The purpose of this model is to check the correlation between the concentration of toxic elements derived from electrosurgical procedures in the operating setting air and the concentration of the same substances in urine and plasma of patients and operating staff. Moreover, it will be considered also the correlation between toxic concentration and time of exposure. The results of the study could be relevant to indicate if individual protection devices are efficacious to make the surgical procedure safe for patients and staff or if any adequacy has to be considered. Some unexpected difficulties delayed the expected results."
Design and production of custom-made prosthetic implants in pectoral reconstruction in patients with Poland Syndrome using integrated CAD/CAM systems
Authors: Baldelli Ilaria , Rovina Alex , Mellini Lorenzo , Ciliberti Rosella , Santi Pierluigi
Published: March 2021

"Poland Syndrome is a rare congenital condition characterized by deformities affecting soft and skeletal tissues of thorax and ipsilateral upper limb. Psychophysical integrity, especially for young people, is influenced by early diagnosis and an effective therapeutic strategy. Reconstructive surgery is the gold standard treatment and developing custom-made implants could dramatically change the outcomes for those patients."
Model of a tracheobronchial tree for the training of bronchoscopy examinations
Authors: Bazurro Simone , Caddori Raffaela , Capurro Clelia , Ricci Serena , Marcutti Simone , Vigo Francesca , Carlini Giorgio , Chirico Marco , Solari Fabio , Casadio Maura , Chessa Manuela
Published: March 2021

"Simulation in medicine has been extensively used for the training of medical students, as well as for learning new procedures or studying complex situations, which need a deep understanding of the clinical case. Specifically, in anesthesia and intensive care, bronchoscopy is a procedure entailing some risks, such as perforation, bleeding or other emergency situations. Therefore, it is necessary to train residents with the use of alternative methods before practicing on patients. In this context, we combined a physical model of the tracheobronchial tree with a virtual reality-based system to create a low-cost simulator for bronchoscopy training. Specifically, we designed and implemented a system combining a physical and a virtual model of the tracheobronchial tree of a specific patient, starting from his/hers CT image. This system represents an innovative simulator combining visual and haptic feedbacks. Indeed, our prototype is intended to enhance clinicians’ skills in a riskless environment."
3D software simulator for primary care training
Authors: De Gloria Alessandro , Chirico Marco , Launo Claudio , Berta Riccardo , Bellotti Francesco , Gioco Giuseppe , Carmosino Ivan
Published: March 2021

"Medical software simulators are used to teach specific procedures that allow the user to follow only a strict sequence of steps without the possibility of alternative, avoiding considering the consequence of an error and then potentially admitting its tolerance. Usually these applications are a state machine implementation where learners must make a specific action to obtain a specific result. In our work we propose a brand-new approach with a “open world” serious game medical simulator, based on Agent Based Model Paradigm. Starting by these concepts, a user can learn and test his skills in a dynamic environment that changes in real time based on his actions. We provide a configurable starting set of conditions (patient heath state, available medical instruments and drugs) to create, potentially, infinite scenarios; alongside these boundary values the game permits to configure real time events that influence patient in an unpredictable way by the user side."
Synergy of digital art, architecture and design using video-mapping in a combined classroom
Authors: Nahún Quintero Milián Héctor , Argelia Aguilera Nora , Ramírez Flores Pablo Guillermo , Hosseini Samira
Published: March 2021

"Technological advances within educational domains permit new teaching systems to emerge. Video-mapping is a technique that involves projecting images on threedimensional surfaces through motion effects. In the case of architectural projects, there are very few uses of videomapping that focus on urban planning and even fewer when the mapping is interactive. However, it is crucial to scale new ways of interpreting design using technologies such as video-mapping. In this research work, the themes of virtual environments, spatial representation, and basic design are combined with video-mapping. Students from the Digital Art and Architecture and the Industrial Design programs worked together in this effort, creating an architectural model made with 3D impressions; the users interacted and selected from the options of colors and textures available for the model city, generating different presentations according to the changes in the settings of the video-mapping software. Thus, this project opened the doors to welcome digital artists into the world of architecture and urbanism."
Por um pensar justo e responsável
Authors: Jacobsen Eneida , Junges Fábio César
Published: March 2021

Recorrendo à compreensão de Theodor Adorno sobre geistige Erfahrung (experiência intelectual/espiritual), o artigo explora as condições de um pensar justo e responsável. A categoria adorniana de geistige Erfahrung diz respeito à experiência humana de pensamento a partir das vítimas da história. De acordo com o filósofo, uma experiência intelectual/espiritual ocorre quando conceitos são capazes de revelar sua substância experiencial, dada pela própria realidade. Argumentamos em favor da importância da experiência intelectual/espiritual, a qual é capaz de penetrar a vida em sua pervasividade, procurando vestígios de esperança em meio às sombras da barbárie que a tudo cobrem. Trata-se, em última instância, da condição fundamental para um pensar justo e responsável.
Mulheres e a violência de gênero no contexto sociocultural e laboral: referência à realidade de Roraima
Authors: Verbicaro Soares Douglas , Santos Alessandra Moura Pedrosa , Sanches Pereira Gabrielle Keller , Oliveira Danielly da Silva
Published: March 2021

O estudo tem por objetivo visibilizar a realidade das mulheres no âmbito laboral, social e coletivo, enfocando a questão da discriminação de gênero, influenciada por fatores histórico-culturais, políticos e religiosos transmitidos através dos séculos, por um modelo patriarcal de submissão feminina. A investigação abordará o tema da mulher destacando o fator humano, ou seja, as mulheres como agentes capazes de realizar qualquer tipo de atividade, não importando os róis de gênero e modelos de masculinidades ou feminidades. Nesse aspecto, considerando as mulheres como seres aptos a realizar, também, atividades tipicamente masculinizadas em um ideal de forte tradição conservadora de discriminação. Foi realizada investigação bibliográfica e documental como procedimento metodológico, utilizando-se a abordagem qualitativa e o método dedutivo. A pesquisa conta com uma investigação bibliográfica multidisciplinar, como a história, as ciências jurídicas, a biologia e etc. A presente pesquisa conclui pela existência de discriminações para as mulheres no Brasil, em especial no Estado de Roraima.
Políticas de desenvolvimento rural sustentável da agricultura familiar uruguaia pré/pós Covid-19
Authors: Miranda Scheuer Junior
Published: March 2021

O artigo tem como objetivo revisar as políticas públicas de desenvolvimento rural sustentável à agricultura familiar uruguaia em dois momentos particulares: as políticas consolidadas (contemporâneas) e em discussão (primordiais), além das políticas que surgiram em decorrência da covid-19 (efêmeras). Para isso, utilizaram-se dados oficiais e leituras transversais em publicações acadêmicas. Nas políticas contemporâneas destacam-se a normativa da agricultura, microcrédito, compras públicas, inocuidade, gênero, jovens, assistência técnica, descentralização das políticas, valorização da produção, fundo de emergência e de desenvolvimento; nas políticas primordiais, a segurança alimentar e nutricional, alimentação escolar, agroecologia, selo da agricultura e equidade de gênero; e, nas políticas efêmeras, o Fundo Solidário Covid-19, Estamos Contigo e o Projeto Campo Solidário. Uruguai vem construindo políticas sólidas às famílias rurais, contudo, durante a emergência sanitária não se constatou uma inovação institucional. A trajetória das políticas é relevante para a convivência com a covid-19, porém a pandemia proporcionou uma “janela de oportunidade conceitual”, explicado pela exploração do potencial produtivo, conservação dos recursos naturais, consumo de alimentos naturais e comercialização em circuitos curtos, potencializando a economia circular. O desenvolvimento rural sustentável da agricultura familiar é um caminho irreversível e imprescindível... Avancemos com isto.
JALAUKAVACHARANA (LEECH THERAPY) ITS INDICATIONS AND
COMPLICATIONS - A BRIEF REVIEW
Authors: Shubhangi Dighade , Seema Naringe , Jain (Gupta) Sangita
Published: March 2021

Jalaukavacharana is the ancient technique used for Raktmokshana, here Jalauka means leeches and avacharana means application. Jalauka is one of the tools for Raktmokshana, among Shring, Alabu and Prachhana where Jalauka, Shring, Alabu are used for Pitta, Vata, Kahpa Doshaj Vyadhi respectively. Jalaukavacharana (leech therapy) is a non-surgical type of Raktamokshana and considered as the most unique and effective method of bloodletting. A lot of research work has been carried out in Ayurveda and Modern medicine to prove efficacy of leech therapy in various disorders. Leeches are widely used in most of the disorders ranging from skin disease to Ischemic heart disease with evidence of successful results. In the present paper effort has been made to review various scientific studies which have been conducted in Ayurveda as well as Modern medicine and study the indications of Jalaukavacharana in various disorders as per Ayurveda and Modern medicine. This paper also studies the possible complications of Jalaukavacharana.

Keywords: Jaloukavacharana, Raktmokshana, Leech therapy, Bloodletting, Hirudo therapy.
AN EXPERIMENTAL STUDY ON TWO SAMPLES OF KASIS GODANTI BHASMA PREPARED BY DIFFERENT METHODS W.S.R. TO ANEMIA
Authors: Malviya Vidhiya , Patil R.K. , Nagle Anil
Published: March 2021

Introduction: The exploration of pharmacological effect on Ayurvedic drugs are only possible through ani-mal experimentation. For the global acceptance of the Kasis Godanti Bhasma (KGB) - A herbo-mineral for-mulation of Ayurveda pharmaceutics, there is needs to revalidate the formulation on all aspects from its safety, efficacy, quality control and animal experimentation. Aims and Objectives: 1. To evaluate the effi-cacy of Kasis Godanti Bhasma 1st and 2nd in Pandu (Anemia). 2. To compare the effectiveness of Kasis Go-danti Bhasma 1st and Kasis Godanti Bhasma 2nd in Pandu (Anemia). Material and Methods: Anemia was induced by intra -peritoneal injection of Phenylhydrazine (PHZ) at 40 mg/kg for 2 days. Rats were divided in six groups of four rats each. The first group is the control group received distillated water. The second group is anemic control group received only Phenylhydrazine at 40 mg/kg for 2 days. Third and fourth groups received KGB 1st 500 mg/kg and 1000 mg/kg respectively. While fifth and sixth groups received KGB 2nd 500 mg/kg and 1000 mg/kg respectively. The vehicle and the Bhasmas were administered from day 2 to day 15 after Phenylhydrazine administration. Blood samples were collected from the orbital vein on day 0 before Phenylhydrazine administration, and on day 2, 7, 15 after Phenylhydrazine injection. Re-sult and Conclusion: Experimental study of KGB-1 and KGB-2 shows satisfactory result. On comparing result of KGB-1 and KGB-2. KGB-2 with both doses of 500 mg and 1000 mg shows significant result in anti-anemic effect. While in KGB-1, only 500 mg dose shows the significant result in anti-anemic effect. On comparing dose of both the samples 500 mg dose of KGB-1 and KGB-2 shows satisfactory result.
MANAGEMENT OF ORAL SUBMUCOSAL FIBROSIS (OSMF) WITH PANCHGAVYA SHUKTA SHODHAN GANDUSHA AS A DINACHARYA PROCEDURE
Authors: Rasane Jaiminikumar Shashank , Menon Sudeep , Patankar Ashutosh B
Published: March 2021

The rate of tobacco in addition to above conditions consumption in various forms in recent years is viewed as an emerging epidemic. The symptoms of OSMF may include burning sensation in mouth, intolerance to spicy, pain in mouth, changes in color of oral mucosa, difficulty in opening of mouth. Mukha rogas have been mentioned in Ayurved, with various treatment modalities especially Gandusha and is one of the im-portant Upakrama in Dincharya. Panchagavya is prepared by mixing five products of cow and used in tra-ditional many applications. Shukta varga includes acidic and partially alcoholic preparations of self-generated nature. Application of Panchagavya externally can reduce the Kaathinyata (Hardness) under the Twacha (skin) of oral cavity.
THE PHYSIOLOGICAL STUDY OF SANCHAYAVSTHA OF SATHKRIYAKALA W.S.R SEASONS (RITUS)
Authors: Saini Mukesh , Sharma Rajesh Kumar , Sharma Dinesh Chandra
Published: March 2021

The Prayojana of Ayurveda is of two types, Maintenance of health a healthy Person, by adopting the Ritu-charya, Dincharya and Sadvritta and curing of a disease of diseased Person, by adopting therapeutic measures. Kriya means Action or treatment. Kala means Time or period. So Shatkriyakala means ‘Appro-priate time Periods to take action/treatment. Acharya Susrutha has narrated detail idea of Shatkriyakala in 21st chapter of Sutrasthana. Shatkriyakala include six stages viz Sanchaya, Prakopa, Prasara, Sthansam-shraya, Vyaktavastha and Bhedavastha. That means 6 (the number Six). Shatkriyakala is distinctive concept of Ayurveda. By knowing the process of shatkriyakala the disease process can be arrest at initial stage and avoid the Probabilities of complications. Acharya Sushrutha already mentions the Kriyakala helps the phy-sician to adopt line of treatment by seeing the vitiated Dosha condition by his intellect and knowledge. So, we can say that the physician who diagnose a disease and treat according to Shatkriyakala will be become a successful Practitioner.

Keywords: Ayurveda, Shatkriyakala, Ritucharya, Dincharya
REVIEW ON HEPATOPROTECTIVE EFFECT OF BERBERIS ARISTATA DC.
Authors: Kiran Paudel , Aku Ramamurthy , Gaurav Sharma
Published: March 2021

Berberis Aristata DC. belonging to the family Berberidaceae, is a shrub used in the alternative medical sys-tems that is native to Northern Himalaya region, Nepal, India and Pakistan. It is commonly known as "Da-ruharidra and Chitra". Berberis aristata DC. is used in Ayurvedic Medicinal system from the beginning of this System. It is widely used as a hepatoproctive, tonic, in urinary disorders, skin diseases, diaphoretic, diuretics and treatment of diarrhoea, Jaundice, Syphilis. Natural source of Berberine is Daruharidra which reduces the inflammation of hepatocytes in liver. The study was aimed to analyze its' hepatoprotective ef-fect on the basis of Modern scientific evidence and Classical Ayurveda references. Ayurvedic literature de-scribes Daruharidra plant is mainly used in Kamala, Prameha, Kustha, Netra Roga, Vrana. Keywords: Berberis Aristata DC., Daruharidra, Hepatoprotective, Jaundice, Anaemia, Liver diseases, Hepa-totoxicity, Hepatitis.