bluuebunny/crossref_metadata_2025 huggingface dataset:
Confronting Populist Authoritarians: The Dynamics of Lula’s Success in Brazil and Erdogan’s Survival in Turkey
Authors:   European Center for Populism Studies (ECPS), Ozturk Ibrahim
Published: December 2023

This article delves into the political trajectories of anti-establishment leaders Inácio Lula da Silva (Lula) in Brazil and Recep Tayyip Erdogan in Turkey, both of whom ascended to power in the early 2000s amid politically fragmented environments. The analysis explores the dynamics of their rise, governance styles, and the factors influencing the retention or loss of power. Lula’s success in the 2022 elections against right-wing populist Jair Bolsonaro is attributed to his adept coalition-building and pragmatic policies. In contrast, Erdogan, facing economic crises and deep political unrest, managed to secure his position in the May 2023 elections, showcasing the complexities of populism. The article examines the leadership qualities, coalition-building strategies, and responses to challenges encountered by Lula and Erdogan. Despite initial similarities, Erdogan’s transformative approach to institutions and the establishment of a self-sustaining clientelist regime contributed to his longevity, in contrast to Bolsonaro’s defeat. The role of clientelism, rent-seeking, and corruption in both countries’ politics is discussed, emphasizing their impact on public perception. Lula’s effective positioning as an alternative to Bolsonaro is contrasted with Turkey’s lack of a convincing opposition. Despite bringing Turkey to the brink, Erdogan’s retention of power is attributed to maintaining a "man of the people" persona amid societal concerns for security and stability. In conclusion, the article underscores the nuanced dynamics of populist leadership, emphasizing the significance of historical context, governance strategies, and external factors in shaping the trajectories of leaders such as Lula and Erdogan.
Challenges and Prospects for Replacement Money in Addressing Corruption Crimes in the Indonesian Corporate World
Authors: Palar Hari , Santiago Faisal
Published: December 2023

This research examines the challenges and prospects of implementing replacement money in tackling criminal acts of corruption in the Indonesian corporate world. The research method was carried out through a normative juridical approach by analyzing related laws, case studies, and interviews with legal and business practitioners. The discussion begins by exploring the legal context, especially Article 18B of Law Number 31 of 1999 concerning the Eradication of Corruption as amended by Law Number 20 of 2001. The results of the research show that the application of replacement money as a legal instrument has significant prospects in providing a deterrent effect. and recover state losses. However, challenges arise in implementation practices, especially regarding the availability of accurate financial data and the company's ability to pay replacement money. Article 18B which provides the legal basis for the application of replacement money also requires further clarification to ensure consistency and effectiveness in handling corruption cases in the corporate world. The research results show that although replacement money has prospects in overcoming criminal acts of corruption in the business sector, additional steps are needed to increase its effectiveness. Recommendations include increasing cooperation between law enforcement agencies and companies, as well as expanding the scope of regulations to cover more aspects of business practices that have the potential to become a venue for corrupt practices. This research contributes to detailing the challenges and prospects for implementing replacement money as a legal instrument in the context of criminal acts of corruption in the Indonesian corporate world.
Yoruba Folksong Philosophical Approach to Health Education: Curbing the Spread of COVID-19
Authors: Ayeyemi Ebenezer Oluwatoyin , Ayokunmi Olaoluwa Marvelous
Published: December 2023

Throughout the world's history, there are cases of epidemics in nearly every country, state, and community at various times. During the dark ages in Africa, a number of diseases led to the premature deaths of young ones, adults, and even the elderly within clans and communities. Back then, people believed that outbreaks were caused by the wrathful gods of their communities, whereas it was the unsanitary living conditions and lack of hygiene that served as catalysts for these epidemics. Consequently, the people constantly remained at risk of incessant outbreaks. However, the Yorubas in Southwest Nigeria, among others, have a rich traditional culture that permeates their daily lives and surroundings. Music, as an integral part of their culture, accompanies all aspects of individual and communal existence. Education is deemed crucial for a good life and health. The Yoruba people have employed diverse methods to instil education in their growing citizens, dating back to the neo-colonial era. These methods include teaching folk songs, folk tales, poems, proverbs, and imitating societal values and norms.
The emergence of COVID-19 with its deadly implications has instilled fear worldwide. Everyone pondered preventive measures through education before considering treatment and cure. Preventing the virus spread became the responsibility of individuals and organizations all levels. This discussion examines the impact of an educational Yoruba folksong that promotes self-restraint to mitigate contact with this deadly disease and recommends their adoption at the local level of human habitation to enhance understanding and adaptation to disease prevention and control measures.
Penerapan Sistem Pengendalian Berbasis IoT (Internet Of Things) Untuk Meningkatkan Efisiensi Proses Pengeringan Pupuk Granul Berbahan Eco Enzim
Authors: Danang Danang , Sasmoko Dani , Swastuti Endang
Published: December 2023

In Indonesia, we see a lot of waste in society that can actually still be reused. By using Eco Enzym, the waste can be processed into many derivative products. Residents of RW VII Gombel Permai, Ngesrep Village, Banyumanik District, Semarang have processed this product, but have experienced problems in the drying process, which is still done manually in the sun. The Community Care Team took the initiative to apply IoT technology to this technology-based dryer. The convenience is that using this tool does not require sunlight, uses UV light so it can kill bad bacteria and can be monitored remotely. Residents are enthusiastic about using it because the process is faster, doesn't require too much physical effort and is cheaper to make.
Economia e Sociedade da aurora ao crepúsculo: a “nova velha história” da obra consagrada de Max Weber
Authors: De Carvalho Marcio José Rosa , Gonçalves Israel Aparecido
Published: December 2023

Este artigo tem o objetivo demonstrar como a obra de Max Weber Economia e Sociedade (EeS) chegou ao seu fim enquanto livro único e fechado em si mesmo. Propõem-se uma análise a partir das bases teóricas da sociologia da circulação e da recepção das ideias. A metodologia deste artigo está na compreensão e explicação dos processos histórico-sociológicos tanto pelo contexto da origem e da construção editorial de EeS, quanto pelo o fim da sua existência formal, tal como a conhecemos, no processo de reestruturação da Max Weber–Gesamtausgabe, MWG, na Alemanha. Para tanto, com base na literatura especializada, demonstra-se 1) que a peça EeS é montada formalmente a partir de uma coleção enorme de fragmentos que mal dialogam entre si; 2) Que, embora seus problemas estejam mais ligados aos aspectos formais, há riscos de distorção na compreensão do valor heurístico do pensamento do autor alemão; 3) que para corrigir seus equívocos a obra foi diluída dentro da MWG em quatro volumes (acompanhados de mais dois volumes de índices e referências de contextualização de leitura) divididos em oito tomos para maior coerência e sentido de organização; e, finalmente, 4) que pela limitação de acesso à nova forma da EeS dentro da MWG, o Brasil, bem como a maioria dos países da América Latina, está trabalhando com material defasado.
Mãos que apoiam: uma proposta de formação em libras para alunos do IFRO - campus Ji-Paraná
Authors: Rodrigues Clarillys Damacena , De Souza Alice Cristina Souza Lacerda Melo , Lima Andréia Mendonça dos Santos , De Oliveira Thalia Rhaney Silva , De Oliveira Kauan Ambrosio , Ambrosio Ivanete Maria
Published: December 2023

O processo de inclusão dos alunos surdos nas classes regulares de ensino e a sua interação no ambiente escolar demanda que as instituições efetivem ações para que esse processo ocorra de modo significativo, oportunizando aos alunos surdos e ouvintes uma maior compreensão e interação sobre o uso da Libras no contexto escolar. Diante da necessidade da ampliação da temática no Instituto Federal de Educação, Ciência e Tecnologia de Rondônia - IFRO/campus Ji-Paraná, o projeto integrador “Mãos que apoiam: uma proposta de formação em LIBRAS para alunos do IFRO Campus Ji-Paraná” teve como objetivo fornecer aos aprendizes de LIBRAS subsídios teóricos e práticos para o exercício da comunicação com as pessoas surdas contribuindo para a divulgação da Libras no campus e na sociedade. Como metodologia, adotamos a oferta de ciclos formativos em Libras destinados aos alunos do ensino técnico e superior, com aulas presenciais e a distância com o apoio do Ambiente Virtual de Aprendizagem - AVA, consolidando as etapas de ensino e pesquisa. Já a extensão ocorreu por meio da realização da Live aberta ao público externo. Ao fim do projeto os estudantes puderam conhecer e praticar a Libras permitindo um maior entrosamento com a comunidade surda presente no Campus.
Legal Issues on Climate Protection at The International Level
Authors: Akhmet Galymzhan , Bekezhanov Dauren , Kozhantayeva Zhaukhar , Jumabayeva Karlygash , Omirali Alima , Rzabay Aktoty
Published: December 2023

Objective: This research focused on the effectiveness of laws related to Natural Resources, Environmental Safety, and Climate Protection at both local and global scales.
 
Methods: A comprehensive survey was conducted among residents of a large metropolitan area to gather data on their usage of urban green spaces and assess their mental well-being. The survey included questions related to the frequency of park visits, types of activities engaged in within green spaces, and self-reported mental health indicators. Statistical analysis, including regression modeling, was employed to examine the relationship between green space utilization and mental well-being.
 
Results: The analysis revealed a significant positive correlation between the frequency of urban green space visits and improved mental well-being among residents. Individuals who visited green spaces more frequently reported lower levels of stress, anxiety, and depression. Moreover, engaging in physical activities and social interactions within these spaces demonstrated an even more pronounced positive impact on mental health.
 
Conclusion: This study underscores the vital role of urban green spaces in promoting the mental well-being of metropolitan residents. Increased access to and utilization of green areas within cities can contribute to lower levels of stress and improved mental health outcomes. Urban planning and policy efforts should prioritize the preservation and creation of green spaces as integral components of urban environments to enhance the overall quality of life for city dwellers.
Prognostic Biomarkers in Sepsis
Authors: ÖZDEMİR Serdar
Published: December 2023

We read with great interest the article titled “Evaluation and Diagnostic Effectiveness of Hemogram, Biochemistry and Inflammatory Markers (Immature Granulocyte, Procalcitonin, CRP, NLR, PLR) in Patients with Sepsis” prepared by Gedik and Çiftçioğlu and published in the second issue of your journal in 2023. We would like to thank the authors and the editorial board for this descriptive study sharing data from a tertiary hospital in Kahramanmaraş province. However, we would like to touch upon a few points that may contribute to the discussion of the study.
FOREST CURTAINS - ONE OF THE SHIELDS AGAINST CLIMATE CHANGES IN ROMANIA'S AGRICULTURE
Authors:   Sport Agra Ltd. Amzacea, Constanta County, Romania; Academy of Romanian Scientists, MANOLE Dumitru , ALBU Gheorghe ,   Viisoara Winery, Constanta County, Romania, POPESCU Agatha ,   University of Agronomic Sciences and Veterinary Medicine of Bucharest, Romania; Academy of Romanian Scientists;  "Gheorghe Ionescu Sisesti" Academy of Agricultural and Forestry Sciences
Published: December 2023

The paper highlights the importance of forest curtains in Romania and especially in Dobrogea region, Constanta County and Oltenia region, Dolj county where agricultural crops are deeply affected by climate changes: long and severe drought, soil degradation and desertification. The paper presents the affected surfaces, and a history of protection curtains giving examples of research results of the experiments and good practices carried out in the year 2020 and 2023 at Amzacea Sport Agra Ltd. regarding the economic effect in terms of yield and production obtained from cultivated crops on areas protected by forest curtains compared to non protected crops. The results proved that the protected crops have performed production gains varying between 25-30% in the good agricultural years and between 29-40% in the bad dry years. The main conclusion is that forest curtains have to be planted on larger surfaces to protect agricultural crops and sustain production performance. They are urgently needed in the regions where irrigation systems are not operating.
ABOUT A POSSIBILITY OF PREDICTING THE CONTRAST SENSITIVITY THROUGH INTENSE PHYSICAL EFFORT IN DIABETIC RETINOPATHY
Authors:   Academy of Romanian Scientists, SPULBER Cătălin , SâRBU Steluţa ,   Bucharest Cultural Events, MORARU Daniela ,   National College Mihai Viteazu, Ploiesti, ISTRATE Sânziana ,   ”Carol Davila” University of Medicine and Pharmacy, Bucharest
Published: December 2023

The present work makes a comparison between the sensitivity to contrast in the case of people with and without diabetic retinopathy, but who perform physical effort or not by walking alertly in the Nordic style. The differences between the two types of state, at rest or systematic movement, were extrapolated, in order to predict the evolution of this quality of human vision. The objective pursued consisted in obtaining relevant arguments for the promotion of current health strategies through sports. The psychophysical tests used to determine contrast sensitivity were supplemented with those which determine the variation in retinal thickness measured by computerized optical tomography
“De røller R”
Authors: Krogager Andersen Line , Daugaard Line Møller
Published: December 2023

In this article, we illustrate how language awareness emerges and evolves through social interaction when students and teachers collaboratively construct beliefs, analyses and understandings of linguistic phenomena and the concept of language as such. The article is a case study of specific forms of manifestation of language awareness in a particular plurilingual context, focusing primarily on one particular student, and considering the ways in which he engages with language in the situated and evolving context of plurilingual language weeks in year 9. The study is based on an extensive selection of empirical data gathered as part of a larger research project investigating language awareness across educational levels, and revolves around student whose ways of manifesting language awareness in the eyes of the authors constituted a rich empirical point for several reasons: the emergent Danish which shapes his manifestations of language awareness in unexpected ways; the observable social origin of particular loci of metalinguistic attention and the ways in which his manifestations of language awareness are both grounded in, shaped by and ultimately shape his position in group work. We analyse each of these perspectives on our focal student’s manifestations of language awareness in three analytical steps, drawing on empirical classroom data in the form of student worksheets, notes and discussions in group work, as well as interview data. We conclude by discussing how the reflections of this three-step analysis affect our theoretical and empirical notion of language awareness as enacted and emergent in the classroom context.
STUDI POTENSI DAN PROBLEMATIKA DESA TERTINGGAL DI KABUPATEN KONAWE SELATAN
Authors: Peribadi Peribadi , Arsya Muhammad , Samsul Samsul , Patuju La , P. Iwan
Published: December 2023

Analysis of all types of resources from the perspective of the Village Development Index (IDM), will clearly show all potential resources as strengths and as opportunities for future development. On the other hand, various life problems are also revealed as weaknesses and challenges that can be anticipated and must even be turned into opportunities for developing disadvantaged village communities. The research aims to describe the various potentials and at the same time the various problems contained in rural areas categorized as Disadvantaged Villages in South Konawe Regency. In this context, the resource potential within the scope of the Social Resilience Index, Economic Resilience and Environmental Resilience is studied from the perspective of the Regulation of the Minister of Villages, Development of Disadvantaged Regions and Transmigration of the Republic of Indonesia Number 2 of 2016 concerning the Developing Village Index. The research uses a qualitative approach which focuses on descriptive studies and phenomenological studies. All components of South Konawe society that are deemed worthy of providing information can be used as primary data sources. Primary data was carried out using participant observation, surveys, deep interviews and Focus Group Discussions. Analysis of the Village Development Index (IDM) through a process of weighting and ranking rural resource potential. The results of the research show that there is a rural area that is classified as a Very Disadvantaged Village (Pritama Village), because it is in the value range of less than 0.4907 and the existence of an area that is in the Disadvantaged Village category because it has a value of less than 0.599. Such conditions indicate vulnerability to natural disasters, economic shocks and social conflicts, so that villages experience difficulties in managing and utilizing the potential of their social, economic and ecological resources. The portrait of rural areas referred to as underdeveloped and very underdeveloped villages depicts the worst condition of resources according to the provisions of the 2016 Minister of Village Regulation, so that it appears very problematic in developing its existence towards developing villages, developed villages and up to independent villages. The existence of underdeveloped and very underdeveloped villages appears on the one hand to have sufficient resource potential to support the development of a rural area and develop the socio-economic welfare of its people. Although on the other hand, it was not able to achieve a score according to the provisions of the 2016 Minister of Village Regulation. In this context, for example, in the education dimension, high points were achieved, but the achievement in the social capital dimension appeared to be very low.
Speech Level of Makeang Luar Language in Makeang Island
Authors: Nurfani  , Farida Maricar  , Rudi S. Tawari
Published: December 2023

This research is about speech levels in Makeang Luar language, one of the two languages in Makeang. Some sources call this language as West Makeang language and others call it Moi language. However, in this research, the term used is the Makeang Luar language as used by the Language Agency, Ministry of Education, Culture, Research and Technology. Although language agency uses the word 'Makian, this research prefers the local term, Makeang. Thus the term used is Makeang language. As a language, Makeang Luar also has a speech level in daily conversation. This is related to local culture. Generally, the speech level in various languages is always related to the level of politeness, civility, or respect for someone, both in the context of position, kinship relations, or accessibility and geographic situations. Therefore, this research will describe the speech levels in Makeang Luar. By using a sociolinguistic theoretical framework, this research will descriptively describe Makeang Luar language which is the object of this research. The speech level in Makeang Luar language can be categorized into two, dimension of the vertical speech level and the horizontal speech level. Vertical speech level is related to differences in age, degree of position or social status of a person, and the relationship between husband and wife. Meanwhile, horizontal speech level is related to peer age and friendship or familiarity.
An Analysis of Students’ Needs in Developing English Textbooks to Improve High Abilities Level of Law Students
Authors: Yosi Marita  , Safnil  , Syukri Hamzah  , Irwan Koto
Published: December 2023

Textbooks are a set of learning materials that are arranged systematically and include competencies that will be mastered by students in learning activities. The presence of textbooks is a crucial element in the teaching and learning process, as they serve as a valuable resource for both students and educators at all levels of education. This research aims to analyze the students’ needs in developing English textbooks to improve high abilities level of law students. This type of research used descriptive qualitative. The research method is a survey through interviews, questionnaires, and documentation, for this reason, a needs analysis questionnaire was given to 56 students to obtain information about their needs in English at the Faculty of Law of Universitas Prof.Dr. Hazairin SH. The results of the data analysis reveal the importance of English textbooks, specifically in the field of Law (English for Specific Purposes). In this case, language skills and reading were more emphasized. Thus, it is concluded that based on the results of the Analysis of textbooks for lecturers, there is a very high need for books with unique characteristics as teaching materials that are suitable for learning English for academic purposes for the Faculty of Law in accordance with ESP principles.
Quantitative Screening of Phytochemicals of five Red Seaweeds from the Northern Kerala Coast, India
Authors: Rao Swapna , Anantharaman P.
Published: December 2023

The Quantitative analysis of 5 phytochemical parameters: Tannins, Flavonoids, Phenols, Steroids, and Terpenoids has been done for 5 Red seaweeds belonging to the family –Rhodophyceae i.e. Gracilaria corticata, Grateloupia lithophila, Gelidium micropterum, Chondracanthus acicularis, and Centroceras clavulatum, from the Northern Kerala coast: Thikkodi, Elathur, Kappad and Beypore, located in the Kozhikode district. Methanolic extracts of the seaweeds were used for the Phytochemical component screening. The study found that Flavonoid content was the lowest among other parameters ranging from 2.61±0.04 mg QE/g dw to 5.57±0.23 QE/g dw. The steroid was found to be higher in the case of C. acicularis (61.32±0.04 mg BSE/g dw) and C. clavulatum (65.80±0.02 mg BSE/g dw). Followed by it was Tannin which was highest in G. micropterum (49.20±0.56 mg CE/g dw) and C. acicularis (32.01±0.24 mg CE/g dw), whereas G. lithophila showed consistently lower concentrations in Phenols (0.19±0.01 mg GAE/g dw), Tannins (9.43±1.59 mg CE/g dw), and Steroids (3.69±0.01 mg BSE/g dw). To the best of our Knowing the current Quantitative analysis of phytochemicals in Red seaweeds is the pioneering work done in the following study areas: Kappad, Elathur, and Beypore. This phytochemical screening with reference to past studies on the same domain confirms that a lot of work needs to be done yet.
Machine Learning Approaches for Pest and Insect Management in Forest Scenario: An Outlook
Authors: Senthilkumar N.  , Sumathi R.
Published: December 2023

Forests are nature's most efficient complex ecological system and vulnerable resources of valuable products which contribute to the sustainable development of communities. In the current scenario of climate change, forest became susceptible to major issues such as diseases, insects, pests and their unpredictable pest outbreaks. The sustainable management and protection of this natural environment from insect, pest, diseases, human interference and unwanted disturbances is vital and needs new tools to find insight and effective management. Computer vision is good at spotting disorder and efficient pre-requisite tool for insect pest management. Hence, introduction of Artificial Intelligence (AI) and Machine Learning (ML) techniques could be an alternate advanced precision approach to detect and control the herbivorous insect pests at an early stage to avoid huge damage to forest and continuous indiscriminate usage of the chemical pesticides. This is an opportunity which benefits farmers, state forest departments, Forest Development Corporation, forest and private nurseries, wood-based industries, paper and pulp industries etc.
Editorial: The Challenges of Interdisciplinary Publishing
Authors: Kane Leia , Allan-Jones Amy , Davidson Graham , Koster Lucy , Tomlinson Logan , Underwood Daniel
Published: December 2023

The Granite editorial team brings together expertise from seven schools across the University, forming a truly interdisciplinary collaboration in itself. While this might suggest that creating an interdisciplinary volume would be a straightforward task, the reality however, has proven to be quite challenging. Our shared vision of recognising the value of innovation and creativity sparked from interdisciplinary collaboration, to address complex real-world issues, and pushing the boundaries between disciplines, has been the driving force behind this edition of Granite. However, it has not been an easy feat.
Die Conforama-Entscheidung der französischen Cour de cassation zur kollisionsrechtlichen Vereinbarung der UNIDROIT-Prinzipien für Internationale Handelsverträge
Authors: von Hein Jan , Vuattoux-Bock Samuel
Published: December 2023

Die französische Cour de cassation hatte kürzlich in ihrem Urteil vom 16. November 2022 die Gelegenheit, sich dazu zu äußern, ob die Unidroit-Prinzipien als Vertragsstatut vor staatlichen Gerichten vereinbart werden können. Die Cour de cassation bekräftigte, dass die Parteiautonomie für einen internationalen Handelsvertrag auf staatliche Rechtsordnungen begrenzt sei, weil die von Unidroit erarbeiteten „allgemeinen Rechtsgrundsätze internationaler Verträge“ kein kollisionsrechtlich wählbares „Recht“ im Sinne des Art. 3 Abs. 1 EVÜ/Rom I-VO darstellten. Somit schloss sich die Cour de cassation der h. M. zur unzulässigen parteiautonomen Vereinbarung der Prinzipien an und bestätigte indirekt die erforderliche Absicherung einer solchen Rechtswahl durch eine Schiedsvereinbarung. Auf die Möglichkeit einer materiellrechtlichen Wirkung der Wahl nicht-staatlichen Rechts (Inkorporation) ging die Cour de cassation jedoch nicht ein. Diesen Fragen soll in dem folgenden Beitrag nachgegangen werden, der Professor Dr. Torsten Stein gewidmet ist.
Lactose Intolerance and Small Intestinal Bacterial Overgrowth (SIBO) in Paediatric Patients with Inflammatory Bowel Disease
Authors: Wiecek Sabina , Buczynska Anna
Published: December 2023

In recent years, an increase in the incidence of Inflammatory Bowel Disease has been observed, with particular emphasis on Crohn’s disease and ulcerative colitis in the paediatric population, also in the youngest age group. Underlying factors are genetic, environmental (including the microbiome) and immunological. Clinical manifestations are very often uncharacteristic, and the clinical picture is dominated by abdominal pain, weight/growth deficiency and/or diarrhoea. Similar symptoms occur in the course of lactose intolerance and small intestinal bacterial overgrowth (SIBO). On the other hand, Inflammatory Bowel Diseases (IBD) seem to favour the onset of SIBO and lactose intolerance. Only the diagnosis of these disease entities ensures appropriate therapeutic management. The manuscript analyses the latest literature on the co-occurrence of these disease entities in patients with IBD—especially Crohn’s disease and ulcerative colitis, clinical symptoms, and diagnostic and therapeutic procedures.
Perspective Chapter: Evaluating New Drugs against K-Ras4B/PDE6δ Using an In Vitro Approach
Authors: A. Carrion-Estrada Dayan , Briseño-Diaz Paola , Delfín-Azuara Sandra , Aguilar-Rojas Arturo , Vargas Miguel
Published: December 2023

Cancer represents the leading cause of global mortality worldwide. Recent estimates have shown that approximately 25% of all cancer types exhibiting KRAS mutations, making these mutations one of the most reported so far. Given the important role played by KRas during the progression of different tumors, the search for new therapeutic compounds that can reduce the adverse effects of this oncogene becomes evident. However, discovering effective anticancer compounds is a complex and time-consuming task. These compounds should ideally exhibit potent anticancer properties at low concentrations, with minimal impact on healthy cells. The validation of potential candidates involves several stages and methods, including in vitro techniques such as cell lines or primary cell cultures grown under 2D and 3D conditions. This chapter provides a comprehensive review of in vitro methods to support the effectiveness of two compounds, C14 and P8, specifically targeting mutant KRas as potential antitumor agents. Cytotoxicity assays were employed on breast and pancreatic cancer cell lines and primary cell cultures grown in 2D and 3D conditions to evaluate the effectiveness of these compounds. The use of multiple cell culture systems provides more pertinent data, enhancing our understanding and assessment of the potential benefits of new therapeutic molecules.
APPLICATION OF THE METHOD OF FREQUENCY-RESONANCE ANALYSIS OF IMPLANTS INSTALLED AFTER AUTOGENOUS BONE TRANSPLANTATION
Authors: Hakobyan Gagik , Yessayan Lazar , Karapetyan Hovhannes , Azbekyan Yuri , Mathevosyan Davit
Published: December 2023

Background: Purpose of study determine the timing of prosthtic rehabilitation of patients after autograft and dental implantation of the jaw bone using resonance-frequency method (RFA).
Methods: The analysis of the treatment of 34 with vertical resorption of the lower jaws, and dental implant prosthetic rehabilitation performed for the period 2020-2023.All patients underwent a complex clinical, laboratory study, computed tomography (CT). At the first stage, the autogen bone grafting procedure, at the second stage, 4 months after autogen bone grafting implants were installed. 3 months later, after implants inserted to determine the timing of prosthetic rehabilitation, the method of RFA-Resonance Frequency Analysis method was used, if normal results were recorded, the prosthodontic phase began. Postoperative clinical and radiological monitoring was regularly conducted, and criteria for the success of implantation and success of prosthetics of implant- supported reconstructions were evaluated. Change in marginal bone levels was assessed by taking digital x-rays immediately after restoration fixation (base line for comparison), after 1 and 3, 5 years post operatively.
Results: No intra-operative or immediate post-operative complications were noted after autografting procedure. The postoperative of the patients was favorable, with the integration of the autografts. 3 months after autogenous bone grafting, the resorption of the graft in some transplant recipients is up to 10%. All of the patients presented with healthy soft tissue.
Marginal bone loss data were recorded, mean marginal bone loss (MBL) was 1.2 ± 0.25 mm after 3 years. The mean RFA recordings of all 136 implants were 65 ISQ at implant placement respectively 73 ISQ after 3 months. The functional load on dental implants was performed with ISQ values above 65 (dental prosthetic rehabilitation was performed after 3-4 months of submerged healing). A total of 8 implant failures were recorded. After 5 years show survival rates 97%.
Conclusions: RFA could serve as a noninvasive diagnostic tool for detecting implant stability during healing stages and subsequent routine follow ups. The method of resonance-frequency analysis allows us to determine the timing of the beginning
of the prosthetic stage in each specific case.
The Children of Conscious Reunion
Authors: Schmidt M.C. ,   After Dinner Conversation
Published: December 2023

Are you duty bound to stop a dubious transaction? In this tale of philosophical short fiction, Ann Marie, a freshly anointed notary’s first client is an elderly woman endeavoring to relinquish her dwelling to “Father,” the enigmatic figurehead of a cult. Ann Marie declines the notary job, as the deed transfer requires both an attesting witness and the beneficiary—neither of which is present. She recounts this incident to a friend. This leads her footsteps to the aged woman’s abode, where a serendipitous encounter with the woman’s son ensues. She leans he has emancipated his mother from the cult’s influence and has forcefully put her into a de-programming facility. However, a looming choice weighs upon him: the possibility of selling her home to fund her transition into a long-term care facility, for her own good.
Yellow Is the Color of Choices
Authors: Milam Penny ,   After Dinner Conversation
Published: December 2023

Is it moral to end your 14-year-old daughters’ pregnancy against her will? In this work of philosophical short story fiction, Megan’s father is divorced. 14-year-old Megan visits her father on weekends. One weekend she begs to go to the local farmers market, only for her father to find out her real motive, to visit a Senior in her High School running a wild honey stall. Her father takes the hint, and gives them time to socialize. For the next few weeks Megan cancels her weekend visits. Only on the fourth weekend does she confess the truth; she is pregnant with the Senior’s baby, and intends to keep it. Her father is furious, but realizes his fury is pushing his daughter away. Instead, he decides to allege his support and provide her with prenatal vitamins, which are really an abortion pill. He feels he has saved her future, but someday he knows she will learn the truth.
Senior High School Mathematics Teachers’ Perception of the Teaching and Learning of Logarithm in the Kwahu East District
Authors: Theophilus Klu Kwasi  , Desire Sokpe  , Justice Aggrey
Published: December 2023

The motive of the study was to find factors that influence the teaching and learning of logarithms at the senior High schools in the Kwahu East Municipality. The study employed a descriptive survey where a questionnaire was administered to Eighty-Six (86) teachers. The sample was selected using the Census method. After the SPSS software was used to analyse the data, the descriptive analysis revealed that most teachers positively perceive logarithms. Factors influencing Senior High School mathematics teachers' teaching of logarithm were identified. Teachers believe that suitable teaching methods can influence students' perceptions. Strategies to encourage positive perceptions should be promoted among teachers, and recommendations include developing innovative methods for teaching logarithms in Senior High School mathematics.
Yerel Yönetimlere Bağlı Spor ve Egzersiz Alanlarından Halkın Beklentileri (Elazığ İl Örneği)
Authors: Genç Yunus , Tel Mikail
Published: December 2023

Yapılan bu araştırmada yerel yönetimler tarafından sunulan spor hizmetlerinden faydalanan bireylerin spor hizmetleri konusundaki görüşlerinin bazı değişkenlere göre incelenmesi amaçlanmıştır. Araştırmaya Elazığ ilinde yerel yönetimler tarafından sunulan spor hizmetlerinden faydalanan 263 kadın ve 237 erkek olmak üzere toplam 500 birey katılmıştır.
 Araştırmaya katılan bireylerin yerel yönetimler tarafından sunulan spor hizmetleri hakkındaki görüşlerinin belirlenmesinde Genç (2016) tarafından geliştirilen “Spor Hizmetlerinden Beklenti Ölçeği” kullanılmıştır (1). Araştırmada elde edilen verilerin istatistiksel analizlerinde SPSS 22.0 veri analiz programında tanımlayıcı istatistikler ile Mann Whitney U testi ve Kruskal Wallis H testi kullanılmıştır. Araştırmanın sonunda katılımcıların düzenli olarak spor yapma alışkanlıklarının düşük olduğu, yerel yönetimler tarafından sunulan spor hizmetlerinden genellikle haftada 2-3 gün yararlandıkları, yerel yönetimlerin sundukları spor tesislerinin yetersiz olduğunu düşündükleri tespit edilmiştir. Araştırmaya katılan bireylerin spor tesislerinde gördükleri yetersizliklerin başında sırasıyla kapasite yetersizliği, antrenör eksikliği ve soyunma odalarının halka açık olmamasının geldiği tespit edilmiştir. Katılımcıların ölçek alt boyutlarından sayısal yeterlilik, tercihler ve iletişim faktörlerinden orta düzeyde puan aldığı, hizmet yeterliliği ve rekreatif faktörlerinden ise orta düzeyin üzerinde puan aldıkları belirlenmiştir. Bunun yanında katılımcıların spor hizmetleri konusundaki görüşlerinin cinsiyet, yaş grubu, eğitim durumu, meslek grubu, gelir durumu, düzenli spor yapma durumu, spor yapmak için tercih ettikleri zaman dilimi, haftalık spor yaptıkları gün sayısı, spor tesislerini haftalık kullanma süresi ve spor tesislerini yeterli bulma değişkenlerine göre istatistiksel açıdan anlamlı farklılık gösterdiği sonucuna ulaşılmıştır (p<0.05).
Engineering system design using the vibrating particles system algorithm
Authors: Lobato Fran Sérgio , Andrade Jéssica Cristiane
Published: December 2023

This contribution aims to apply the Vibrating Particles System Algorithm (VPSA) in engineering system design. In general, this optimization strategy is based on free vibration simulation of a sub-damped system constituted by particles that gradually tend to equilibrium positions. In order to evaluate the capacity of this optimization strategy, three classical problems in engineering context (welded beam design, pressure vessel design and tension/compression spring design) are studied. The obtained results demonstrate that the VPSA configures an interesting alternative to engineering system design compared with other heuristic approaches.
Computational model validation of the rolled shapes calendering process
Authors: Moreira Mauricio da Silva , Souza João Henrique Corrêa de , Guilherme Carlos Eduardo Marcos , Isoldi Liércio André
Published: December 2023

This paper presents the validation of computational model for the numerical simulating of the 3-roll calendering process. For this, a case study was carried out, considering a rolled I-form S235 steel profile subjected to vertical loads imposed by the calender rolls. Residual stress results obtained numerically were compared with experimental results found in the literature. The computational model was developed in ANSYS® software, which relies on the Finite Element Method (FEM), considering four different types of three-dimensional finite elements: SOLID185, SOLID186, SOLID187, and SOLID285. The results indicated that the computational model with SOLID186 presented stable mesh convergence, obtaining a discrepancy of -1.61% when compared to the experimental results, thus validating the proposed computational model.
Desempenho do teste ADF em séries estacionárias na presença de quebras estruturais
Authors: Amaral Mariane Coelho , Silveira Anderson , Mattos Viviane Leite Dias de , Konrath Andrea Cristina , Nakamura Luiz Ricardo
Published: December 2023

O estudo de séries temporais vem se tornando cada vez mais necessário, dado o volume de dados observados e medidos ao longo dos anos. Dentre as características mais importantes das séries temporais, tem-se a estacionariedade, que é majoritariamente analisada pelos testes de raiz unitária. É consenso na literatura que as quebras estruturais, quando presentes nas séries, podem viesar o resultado do Teste de Dickey-Fuller Aumentado (ADF). No entanto, até o momento, a intensidade com que as quebras afetam o poder do teste ADF não é clara, dificultando a tomada de decisão acerca da utilização deste teste e podendo induzir a erros quando a série contar com rupturas estruturais. Este trabalho comprova a influência de quebras estruturais do tipo level shift (LS) na análise de estacionariedade em séries temporais anuais estacionárias pelo do Teste ADF, quantificando seu poder. Conclui-se que o Teste ADF tende a não rejeitar a hipótese nula na presença de rupturas em uma possível confusão com a presença de raiz unitária. Ainda, ao aumentar a perturbação inicial ω, o poder do teste foi sendo rapidamente reduzido, principalmente com quebras de mudança de nível imputadas nas posições mais próximas à origem da série de dados.
XXV ENMC / XIII ECTM / 9º MCSul / IX SEMENGO
Authors: Buske Daniela
Published: December 2023

In 2022, the events XXV National Meeting of Computational Modeling (XXV ENMC) and XIII Meeting of Science and Technology of Materials (XIII ECTM) took place from October 19 to 21, 2022, with all activities of the event carried out in the webinar modality. In this particular year, together with the XXV ENMC and the XIII ECTM, the 9th Southern Conference on Computational Modeling (9th MCSul) and the IX Seminar and Workshop on Ocean Engineering (IX SEMENGO) were held, providing the opportunity to bring together researchers from related areas of knowledge.
The events included lectures from the area of Computational Modeling in Brazil and abroad; its organization was the result of a collaboration between professors from ten public teaching institutions in the country, under the coordination of researchers from universities in Rio Grande do Sul; the event had more than 250 manuscripts submitted and presented in 57 technical sessions, with emphasis on the contributions made by graduate students.
The Organizing Committee selected a sample of original works presented at the event with an interdisciplinary theme. This led to the publication, in December 2023, of this special edition of the XXV ENMC / XIII ECTM / 9º MCSul / IX SEMENGO. We thank the authors who contributed to the high level of this edition.
We wish you all a pleasant reading.
Kajian Pengelolaan Lingkungan Berdasarkan Ensiklik Laudato Si dan Teologi Lingkungan Muhammadiyah
Authors: Jeremia Setiadi Dionisius , Marcelinus Natanael Gabriel , Ziaul Haq Mochamad
Published: December 2023

Manusia merupakan makhluk yang secara spesial dipilih Allah untuk menjaga bumi tempat tinggalnya. Kekhususan ini mengandung konsekuensi yang tidak dapat dihindarakan, yaitu tanggung jawab kepada Allah dan makhluk lainnya yang hidup di dunia. Sayangnya, tugas dan tanggung jawab ini seringkali terabaikan dan manusia hanya fokus pada dirinya. Melalui dokumen berjudul Laudato Si yang ditulis Paus Fransiskus, ia ingin kembali menyadarkan manusia kembali pada hakekatnya sebagai penjaga dan pelestari bumi. Selain itu, dalam pengajaran dari Agama Islam yang direpresentasikan dalam pemikiran Teologi Lingkungan Muhammadiyah ingin menyadarkan kembali kebersatuan manusia dengan Allah melalui alam ciptaanNya. Dengan menggunakan kajian integritas terbuka dan metode kualitatif, tulisan ini berupaya mendalami gagasan dari Laudato Si dan Teologi Lingkungan Muhammadiyah, serta mengambil langkah aplikatif dan mencari sintesis gagasan dari dua agama tersebut.
Efecto de la fracturación en el muestreo petrofísico de núcleos para la estimación de porosidad y permeabilidad
Authors: Rossello Eduardo Antonio , Laprea-Bigott Marcelo
Published: December 2023

Los muestreos petrofísicos son una herramienta esencial para determinar la porosidad y permeabilidad de una roca reservorio con el objetivo de comprender sus condiciones de almacenamiento, recuperación y productividad de los fluidos que contiene, y así evaluar el potencial económico de un proyecto exploratorio. Sin embargo, el tamaño limitado de los diferentes tipos de núcleos condiciona la verdadera validez de sus determinaciones cuando se extrapolan al resto del yacimiento. La limitación mecánica en la extracción de núcleos (plugs-tapones) en áreas litológicas sin fracturas no logra reflejar el comportamiento del conjunto rocoso. Los resultados de porosidad y permeabilidad obtenidos de mediciones de laboratorio, al caracterizar solo las condiciones de la roca indeformada, son significativamente inferiores a los valores del conjunto cuando se incorpora la contribución de las fracturas. En este estudio, se investiga la influencia de la fracturación en el muestreo petrofísico de litologías heterogéneas de núcleos para la determinación de la porosidad y permeabilidad en rocas reservorio. Se analiza cómo las fracturas pueden afectar las mediciones petrofísicas y cómo esto puede impactar la precisión de las estimaciones de porosidad y permeabilidad en la evaluación de los yacimientos. Los resultados obtenidos proporcionan información petrofísica valiosa para mejorar las técnicas de muestreo en áreas con presencia de fracturas para la mejor caracterización de los reservorios y una toma de decisiones más informada en la industria del petróleo y gas.
Comparación de los resultados de diferentes métodos de ensayo para evaluar la potencial reactividad de arenas del sur de la provincia de Buenos Aires frente a la reacción álcali-sílice
Authors: Berezosky Juan José , Falcone Darío , Locati Francisco , Marfil Silvina A.
Published: December 2023

Se estudiaron las arenas de cinco canteras ubicadas en el sur de la provincia de Buenos Aires y una del norte de la provincia de Río Negro, calificadas como potencialmente reactivas frente a la reacción álcali-sílice (RAS) en trabajos previos según el ensayo acelerado de la barra de mortero (IRAM 1674). Se realizó un estudio petrográfico de detalle (IRAM 1649) cuantificando los componentes potencialmente reactivos, así como ensayos físicos complementarios según el ensayo del prisma de hormigón (IRAM 1700) convencional (a 38 °C) y acelerado (a 60 °C), y se compararon los resultados con los obtenidos previamente. Se concluyó que todas las arenas contienen vidrio volcánico, como trizas de vidrio fresco y en la mesostasis de algunas rocas volcánicas como especies deletéreas frente a la RAS, a pesar de tener diferentes proveniencias. Si bien todas las canteras analizadas fueron calificadas como potencialmente reactivas según el ensayo petrográfico y el ensayo acelerado de la barra de mortero, en el prisma de hormigón (tanto acelerado como convencional), tienen comportamiento variable. Solo la arena de la cantera 5 arrojó resultados por encima de los límites establecidos por todos los métodos de ensayos normalizados utilizados para evaluar la potencial reactividad frente a la RAS, por lo que se califica como potencialmente reactiva. Su reactividad se ha confirmado por el desarrollo de la RAS en estructuras en servicio.