bluuebunny/crossref_metadata_2025 huggingface dataset:
5‐Hydroxymethylfurfural reduces skeletal muscle superoxide production and modifies force production in rats exposed to hypobaric hypoxia
Authors: Ciarlone Geoffrey E. , Swift Joshua M. , Williams Brian T. , Mahon Richard T. , Roney Nicholas G. , Yu Tianzheng , Gasier Heath G.
Published: July 2023

Decreased blood‐tissue oxygenation at high altitude (HA) increases mitochondrial oxidant production and reduces exercise capacity. 5‐Hydroxymethylfurfural (5‐HMF) is an antioxidant that increases hemoglobin's binding affinity for oxygen. For these reasons, we hypothesized that 5‐HMF would improve muscle performance in rats exposed to a simulated HA of ~5500 m. A secondary objective was to measure mitochondrial activity and dynamic regulation of fission and fusion because they are linked processes impacted by HA. Fisher 344 rats received 5‐HMF (40 mg/kg/day) or vehicle during exposure to sea level or HA for 72 h. Right ankle plantarflexor muscle function was measured pre‐ and post‐exposure. Post‐exposure measurements included arterial blood gas and complete blood count, flexor digitorum brevis myofiber superoxide production and mitochondrial membrane potential (ΔΨm), and mitochondrial dynamic regulation in the soleus muscle. HA reduced blood oxygenation, increased superoxide levels and lowered ΔΨm, responses that were accompanied by decreased peak isometric torque and force production at frequencies >75 Hz. 5‐HMF increased isometric force production and lowered oxidant production at sea level. In HA exposed animals, 5‐HMF prevented a decline in isometric force production at 75–125 Hz, prevented an increase in superoxide levels, further decreased ΔΨm, and increased mitochondrial fusion 2 protein expression. These results suggest that 5‐HMF may prevent a decrease in hypoxic force production during submaximal isometric contractions by an antioxidant mechanism.
Some aspects of the n-ary orthogonal and b
(α

n
,β

n
)-best approximations of b
(α

n
,β

n
)-hypermetric spaces over Banach algebras
Authors: Nezhad Akbar Dehghan , Paunovic Marija , Savic Ana , Radenović Stojan
Published: July 2023

In this article, a definition of a

b

(

α

n

,

β

n

)

{b}_{\left({\alpha }_{n},{\beta }_{n})}

-best approximations of

b

(

α

n

,

β

n

)

{b}_{\left({\alpha }_{n},{\beta }_{n})}

-hypermetric spaces over Banach algebras is given. Our objective is to prove the concept of extension of fixed point theorems in

n

n

-ary orthogonal

b

(

α

n

,

β

n

)

{b}_{\left({\alpha }_{n},{\beta }_{n})}

-hypermetric spaces over Banach algebras.
Basic word order typology revisited: a crosslinguistic quantitative study based on UD and WALS
Authors: Yan Jianwei , Liu Haitao
Published: July 2023

This study quantitatively examines the first five universals of Greenberg’s basic word order typology based on 74 large-scale annotated corpora from two perspectives. The results show that (1) the dominant orders extracted from corpora concur with those retrieved from the World Atlas of Language Structures (henceforth, WALS) and provide knowledge of dominant orders to languages absent in the WALS, demonstrating the feasibility of adopting corpora to determine dominant orders in typological studies; (2) approaching word order as a discrete variable suggests that the relative order of adjective and noun cannot be predicted by the relative orders of object and verb and genitive and noun, which means the violation of Greenberg’s related universal; (3) approaching word order as a continuous variable also indicates the violation of this universal; and (4) the language samples based on the annotated corpora database further demonstrates that languages that are in line with this universal are rare and internally heterogeneous. Our findings suggest the possibility of drawing typological conclusions based on the frequencies and probabilities extracted from corpora materials and demonstrate that a more cautious adoption of the well-known universals is needed, indicating the importance of viewing word order features from various perspectives to better capture the characteristics of natural languages.
Modifications of Longworth traps to prevent wear and improve catchability of shrews (Sorex spp.)
Authors: Tolkachev Oleg , Maklakov Kirill
Published: July 2023

Longworth live traps are widely used for trapping mouse-sized rodents and shrews. However, they have a number of disadvantages: some have a manufacturing defect, resulting in reduced sensitivity; smaller species of shrews can pass under the treadle, avoiding capture; captured animals can gnaw specific parts of the sidewalls and decrease the durability of the traps. To increase the efficiency of catching small shrews, we added a movable tin ramp to the treadle of the Longworth live traps and used washers to improve the design. To repair and protect traps damaged by captured animals, we used tin patches. The modified traps were shown to be significantly better than the original traps in catching small shrew species (Sorex caecutiens Laxmann 1788, Sorex minutus Linnaeus, 1766). Tin patches reliably protected live traps from further damages by animals and do not affect their catching efficiency.
Four-dimensional experimental characterization of partially coherent light using incoherent modal decomposition
Authors: Lu Xingyuan , Wang Zhuoyi , Zhao Chengliang , Zhan Qiwen , Cai Yangjian
Published: July 2023

The intensity distributions and statistics of partially coherent light fields with random fluctuations have proven to be more robust than for coherent light. However, its full potential in practical applications has not been realized due to the lack of four-dimensional optical field measurement. Here, a general incoherent modal decomposition method of partially coherent light field is proposed and demonstrated experimentally. The decomposed random modes can be used to, but not limited to, reconstruct average intensity, cross-spectral density, and orthogonal decomposition properties of the partially coherent light fields. The versatility and flexibility of this method allows it to reveal the invariance of light fields and to retrieve embedded information after propagation through complex media. The Gaussian-shell-model beam and partially coherent Gaussian array are used as examples to demonstrate the reconstruction and even prediction of second-order statistics. This method is expected to pave the way for applications of partially coherent light in optical imaging, optical encryption, and antiturbulence optical communication.
An overview of the synthesis of silicon carbide–boron carbide composite powders
Authors: Zhang Wei
Published: July 2023

Recently, silicon carbide–boron carbide composite ceramics have attracted more and more attention. The most important achievements of the silicon carbide–boron carbide composite ceramics should be applied in terms of mechanical, physical, and chemical for use in various advanced industries, such as armor plates, nozzles, abrasive tools, mechanical seals, etc. To prepare silicon carbide–boron carbide composite ceramics with good performance, the synthesis of silicon carbide–boron carbide composite powders is the basis. The synthesis approaches of silicon carbide–boron carbide composite powders are systematically summarized in this review, including ball milling, high-energy ball milling, self-propagating high-temperature synthesis (SHS), and sol–gel. Particularly, nanosized silicon carbide–boron carbide composite powders can be in situ synthesized by high-energy ball milling, SHS, or sol–gel. When commercial silicon carbide and/or boron carbide powders are used as raw materials to synthesize silicon carbide–boron carbide composite powders, the pretreatment of acid etching can significantly remove oxide layers existing on the surfaces of initial powders.
Digital healthcare: A topical and futuristic review of technological and robotic revolution
Authors: Shilpa  , Kaur Tarandeep , Garg Rachit
Published: July 2023

Healthcare sector has become one of the challenging sectors to handle patient records as well as to provide better treatment to patients within a limited period. Covid-19 also exposed the limitations of the healthcare system due to the lack of better services. So, the involvement of information and communication technologies (ICTs) with the healthcare sector brings radical changes at global as well as local levels such as in hospitals and dispensaries. The article enlightened a novel survey technological paradigm that helps to facilitate the digital healthcare. With the use of technologies, the healthcare sectors are becoming more digital, innovative, patient-centric, and more effective. This article explores the proposed technological developments such as real-time health monitoring, generation of electronic health records, patient health record, mhealth, robotics, as well as robot sensors that are associated with healthcare sectors. This article also highlights the role of ICTs in different healthcare-related fields such as education, hospital management, health-related research, and data management as well as lightening the delivery levels of healthcare services. The article deals with the robotic applications in the healthcare field. This article categorizes the technologies as current and futuristic technological innovations enabling healthcare-as-a-service with benefits.
On the distance energy of k-uniform hypergraphs
Authors: Sharma Kshitij , Panda Swarup Kumar
Published: July 2023

In this article, we extend the concept of distance energy for hypergraphs. We first establish a relation between the distance energy and the distance spectral radius. Then, we obtain some bounds for the distance energy in terms of some invariant of hypergraphs such as the determinant of the distance matrix, number of vertices, and Wiener index along with the distance energy of join of

k

k

-uniform hypergraphs. Furthermore, it is shown that the determinant of the distance matrix of

k

k

-uniform hyperstar on

n

n

vertices is

(

−
1

)

n
−
1

(

n
−
1

)

k

n
−
k

k
−
1

{\left(-1)}^{n-1}\left(n-1){k}^{\tfrac{n-k}{k-1}}

. Later, the distance spectrum of

k

k

-uniform hyperstar is obtained, which gives the explicit distance energy of

k

k

-uniform hyperstar.
State-Building/State-Destroying in Ethiopia – A Backdrop to the Tigray Genocide
Authors: Abbay Alemseged
Published: July 2023

Federalist Tigray and unitarian Amhara have been historical rivals in the daunting task of state-building in Ethiopia. To neutralize Tigray and its de facto federalism (1872–89), Amhara found a formidable ally in Italy, which colluded with Britian to have “a place in the sun.” Amhara rewarded Italy with half of Tigray, which was christened “Eritrea,” and imposed the unitarian system in the country. Worse still, in the middle of the 1950s, Amhara annexed the western and southern parts of Tigray. Tigray and Eritrea (which returned to Ethiopia in 1952) were suffocated by amharanization and political centralization, the twin pillars of the unitarian system. Military insurgencies brought the system to an end in 1991 and the Tigrayans who assumed the reins of power introduced de jure federalism, to the chagrin of the Amhara. The paper offers a critical historical analysis of state-building and state-destroying in Ethiopia, with particular attention given to the Amhara return to power in 2018 and humanity’s newest genocide in Tigray.
Linear and Change of Direction Repeated Sprint Ability Tests: A Systematic Review
Authors: Kyles Aaron , Oliver Jon L. , Cahill Micheál J. , Lloyd Rhodri S. , Pedley Jason
Published: July 2023

Kyles, A, Oliver, JL, Cahill, MJ, Lloyd, RS, and Pedley, J. Linear and change of direction repeated sprint ability tests: a systematic review. J Strength Cond Res 37(8): 1703–1717, 2023—The ability to repeatedly sprint is important in many sports, but there is no established protocol for measuring repeated sprint ability (RSA). The purpose of this review was to identify overground RSA protocols previously reported in the literature and to recommend standardized protocols. A systematic review of the literature was used to identify studies that have used an RSA test, with data describing protocol design extracted. One hundred eight studies were included in the review, across which 47 unique protocols were identified. Eighteen protocols included at least one change of direction (COD), and this increased mean sprint time compared with linear RSA tests (7.26 ± 1.84 vs. 4.48 ± 1.02 seconds). There was considerable variability across protocols regarding sprint distance (20–40 m), sprint repetitions (3–15), recovery duration (10–60 seconds), recovery type (active vs. passive), and work-to-rest ratio (≤1:1.4–19.2). Separate protocols are needed for linear and COD tests, and these should reflect the brief nature of intense periods of competition and stress the ability to recover. Based on data across studies for protocol design and to ensure a demanding work-to-rest ratio, it is suggested that a linear RSA should comprise 6 × 30 m sprints separated by 15 seconds of active recovery. To provide some parity to linear tests, to keep work duration brief and to maintain a demanding work-to-rest ratio, a COD RSA should comprise 6 × 30 m shuttle sprints (15 + 15 m), providing one change of direction (180° COD), and maintaining a 15-second active recovery.
Experimental and Analytical Study on Optimal Spacing for Hard-Rock Breaking under Double-Indenter Impact
Authors: Yue Zhongwen , Wang Peng , Li Akang , Ren Meng , Gao Dan , Bu Wenyang , Han Hui
Published: July 2023

Rock breaking by double hydraulic hammers has a wide application prospect in hard-rock roadway excavation because of its environmental protection and strong rock-breaking ability, but the optimal spacing under double-indenter synchronous impact is not clear. Based on the rock-breaking experimental system under double-indenter synchronous impact established by combining a detachable double-indenter device and Hopkinson pressure bar, the impact tests of three kinds of rocks are carried out, and a theoretical model of specific energy consumption is derived to determine the optimal spacing. The results show that when the indenter spacing is 28 mm, 42 mm, and 14 mm, respectively—that is, when the cross section of the fragmentation crater is in the shape of a “peanut” with a fine middle and two large ends—the concrete, limestone, and sandstone specimens reach the minimum specific energy consumption, which is reduced by 22.55 %, 30.60 %, and 11.85 %, respectively, compared with single-indenter impact. The theoretical model, which explains and verifies the experimental phenomena and results well, can be divided into four zones, and the optimal spacing is in Zone III. The research can be helpful for actual hard-rock tunneling under double hydraulic hammers.
Contribuição da musicoterapia no transtorno do espectro autista: revisão integrativa da literatura / Contribution of music therapy to autism spectrum disorder: an integrative literature review
Authors: De Oliveira Francisca Vieira , Rêgo Neta Marly Marques , Magalhães Juliana Macêdo , Oliveira Adélia Dalva da Silva , Amorim Fernanda Claudia Miranda , De Carvalho Claudia Maria Sousa
Published: July 2023

Objetivo: verificar as evidências científicas sobre a contribuição da musicoterapia como intervenção no tratamento da criança com Transtorno Espectro Autista. Métodos: Trata-se de uma revisão integrativa da literatura, realizada na base de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde e na Medical Literature Analysis and Retrieval System Online. A busca dos artigos foi realizada de janeiro a março de 2019, utilizando os seguintes descritores controlados: Musicoterapia, Terapêutica e Transtorno autístico que que atenderam aos critérios de inclusão e exclusão do estudo. Resultados: Doze artigos evidenciaram o valor da música e o seu papel como recurso terapêutico em crianças. Conclusão: Analisou doze estudos que enfatizam o uso da musicoterapia como ferramenta de tratamento no TEA, tendo em vista que onze estudos descrevem a forma significativa na melhora do quadro clínico e/psicológico de crianças com Transtorno do Espectro Autista, ao proporcionar melhora na comunicação e na socialização.
Utilização das práticas integrativas e complementares em saúde no pré-natal: revisão integrativa/ Use of integrative and complementary health practices in prenatal: an integrative review
Authors: Roblejo Elida Sabrina dos Santos , Torres Joel Roblejo , Abade Erik Asley Ferreira
Published: July 2023

Objetivo: identificar na literatura a utilização das práticas integrativas e complementares em saúde no pré-natal. Método: revisão integrativa realizada entre maio de 2019 e março de 2021 em três bases de dados. Conforme protocolo pré-definido foram selecionados 18 trabalhos para análise crítica a partir da questão norteadora “Quais práticas integrativas e complementares em saúde são usadas no pré-natal?” Resultados: os estudos foram classificados em dois grupos: práticas usadas pelas gestantes e práticas indicadas por profissionais. A prática mais usada pelas gestantes foi a fitoterapia e as mais indicadas pelos profissionais foram homeopatia e medicina tradicional chinesa. A categoria profissional que mais apareceu fazendo trabalho a respeito do tema foi a enfermagem. Conclusões: todas as práticas indicadas pelos profissionais trouxeram benefícios para as gestantes, mostrando segurança em sua utilização. Contudo, as práticas não são incorporadas em sua totalidade, o que indica a necessidade de ampliação de seu uso durante o pré-natal.
Prevalência de violência contra a mulher e suas repercussões na maternidade / Prevalence of violence against women and its repercussions in maternity
Authors: Rodrigues Priscila Alberton , Cicolella Dayane de Aguiar , Mariot Márcia Dornelles Machado
Published: July 2023

Objetivo: verificar a prevalência de violência contra a mulher e as suas repercussões no processo de maternidade. Método: estudo transversal, realizado no alojamento conjunto de um hospital da região metropolitana de Porto Alegre com 174 mulheres. Resultados: observou-se no estudo que maioria das entrevistadas já vivenciaram algum tipo de violência ao longo da vida (79,2%) e (23,7%) delas, durante o período gestacional. Destaca-se que o principal agressor na maioria dos casos foi o companheiro (47,9%) e que elas relataram que o fato de terem sofrido violência poderá influenciar nos cuidados com seu filho. Conclusões: ter sofrido violência não influenciou na decisão da maioria das entrevistadas de serem mães, mas, sim, na propensão aos cuidados excessivos com seu filho.
Avaliação do nível de estresse em acadêmicos de enfermagem de uma universidade pública / Stress level assessment in nursing students of a public university
Authors: Alves Gabriela Rodrigues dos Santos , Ferreira Eric Batista , Monteiro Cristiane Aparecida Silveira , De Andrade Maria Betânia Tinti , Alves Mariane Inaraí , Bressan Vânia Regina , Da Silva Simone Albino
Published: July 2023

Objetivo: avaliar o estresse em acadêmicos de enfermagem de uma universidade pública, identificando seu nível, comparando-o entre diferentes períodos e verificando correlação entre variáveis socioeconômicas. Método: estudo transversal, com 93 acadêmicos de 128, selecionados por conveniência. Dados coletados em dezembro de 2019, com instrumento socioeconômico e Escala de Avaliação de Estresse em Estudantes de Enfermagem. Análise feita com testes de Qui-quadrado, exato de Fisher, Análise de Variância e Scott-Knott, 5% de significância. Resultados: predominou o nível médio de estresse (63,44%). Morar em república foi associado aos escores alto e médio de estresse comparado a morar com família (P=0,04). Nunca ter trabalhado foi associado aos escores altos de estresse.  Concluintes apresentaram nível muito alto de estresse em “Formação Profissional” (13,71) e nível alto de estresse em “Realização das Atividades Práticas” (13) e “Comunicação Profissional” (7,28). Conclusão: a avaliação indica necessidade de intervenções sociais e na formação profissional.
Cultura de segurança do paciente em centro cirúrgico na perspectiva da equipe de enfermagem / Patient safety culture in surgical center from perspective of the nursing team
Authors: Fagundes Thaís Ender , Acosta Adriano da Silva , Gouvea Pollyana Bortholazzi , Massaroli Rodrigo , Rangel Rita de Cássia Teixeira , Andrade Patrícia Daiana
Published: July 2023

Objetivo: analisar a cultura de segurança do paciente em Centro Cirúrgico na perspectiva da equipe de enfermagem. Método: estudo transversal desenvolvido em dois hospitais da região sul do país, com 77 profissionais de enfermagem do Centro Cirúrgico. Os dados foram coletados entre junho e julho de 2019, por meio da aplicação do questionário Hospital Survey on Patient Safety Culture. Na análise e interpretação de dados foi seguido as diretrizes da Agency for Healthcare Research and Quality. Resultados: comparando os hospitais, o hospital 2 teve maior frequência de positividade na dimensão “expectativas e ações de promoção da segurança do paciente do supervisor/gerente” (p<0,001). Já para a dimensão “trabalho em equipe entre as unidades do hospital”, o hospital 1 teve maior frequência (p=0,028). Conclusão: os resultados indicam que a cultura de segurança precisa ser fortalecida nos locais do estudo, com especial atenção àquelas dimensões com avaliação menos positiva.
Unrepaired base excision repair intermediates in template DNA strands trigger replication fork collapse and PARP inhibitor sensitivity
Authors: Serrano‐Benitez Almudena , Wells Sophie E , Drummond‐Clarke Lylah , Russo Lilian C , Thomas John Christopher , Leal Giovanna A , Farrow Mark , Edgerton James Michael , Balasubramanian Shankar , Yang Ming , Frezza Christian , Gautam Amit , Brazina Jan , Burdova Kamila , Hoch Nicolas C , Jackson Stephen P , Caldecott Keith W
Published: July 2023

DNA single‐strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To address this question, we exploited an exquisite sensitivity of SSB repair‐defective human cells lacking PARP activity or XRCC1 to the thymidine analogue 5‐chloro‐2′‐deoxyuridine (CldU). We show that incubation with CldU in these cells results in chromosome breakage, sister chromatid exchange, and cytotoxicity by a mechanism that depends on the S phase activity of uracil DNA glycosylase (UNG). Importantly, we show that CldU incorporation in one cell cycle is cytotoxic only during the following cell cycle, when it is present in template DNA. In agreement with this, while UNG induces SSBs both in nascent strands behind replication forks and in template strands ahead of replication forks, only the latter trigger fork collapse and chromosome breakage. Finally, we show that BRCA‐defective cells are hypersensitive to CldU, either alone and/or in combination with PARP inhibitor, suggesting that CldU may have clinical utility.
Secondary glaucoma associated with idiopathic dilation of the episcleral veins (clinical case)
Authors: Makarevich Ekaterina S. , Fedyashev Gleb A. , Eliseeva Ekaterina V. , Poddubny Evgeny A.
Published: July 2023

The ophthalmic community does not have specific data on the epidemiology of secondary glaucoma against the background of idiopathic expansion of the episcleral veins, risk factors for the development of this disease. There are no generally accepted guidelines for the management and treatment of such patients. Based on our own observation, this paper presents data on the diagnostic tactics and tactics of treating a patient with secondary glaucoma against the background of idiopathic expansion of the episcleral veins.
Changes in the characteristics of the oral fluid in smokers of electronic cigarettes and tobacco heating systems
Authors: Kishkan Alexey A.
Published: July 2023

Objective: to evaluate the effect of smoking electronic (SE) cigarettes and tobacco heating systems (THS) on the characteristics of changes in the characteristics of the oral fluid. Material and methods. The results of analysis of oral fluid samples of 150 persons were studied: smoking ES/THS — 50 people each in the group; control group — 50 clinically healthy non-users of ES/THS. Results. Patients in the THS group have a lower salivary secretion rate, a higher oral fluid viscosity at a more neutral salivary pH than control group (p=0.002); whereas patients of the ES group in comparison with the THS group are characterized by a higher saliva secretion rate, a lower viscosity index of the oral fluid at a neutral saliva pH level (p>0.05). Differences were observed in biochemical parameters of total protein concentration (p=0.001), oral fluid calcium concentration (p=0.005), malonic dialdehyde (p=0.007), alkaline phosphatase, and salivary catalase concentration (p=0.004 and p=0.006, respectively) between THS smokers and control group. Conclusion. Smoking THS to a greater extent in comparison with ES and especially with control group reduces the rate of salivation, increases the viscosity of the oral fluid; in this group of smokers, in comparison with ES smokers, a more neutral value of oral fluid acidity was revealed, the concentration of total protein, malonic dialdehyde, phosphates and calcium in saliva was increased with a decrease in alkaline phosphatase and catalase concentrations.
Treatment of a brain abscess after a new coronavirus infection (COVID-19) (clinical case)
Authors: Vakatov Dmitry V. , Fomenko Artyom A. , Bagretsova Inna N. , Gorozhanin Alexander V. , Chekhonatskiy Vladimir A.
Published: July 2023

Objective: to demonstrate the diagnostic features and successful outcome of the combined treatment of a temporoparietal abscess in the left cerebral hemisphere after a patient underwent COVID-19. The choice of a technique for surgical treatment of a brain abscess formed after COVID-19 is very difficult in view of the possible development of secondary hemorrhagic and infectious complications in such patients in the postoperative period. In the presented clinical case, the surgical manual was chosen in the volume of closed external drainage of the abscess cavity using a surgical navigation station and sowing on microflora. In combination with well-chosen antibacterial therapy, this made it possible to reduce the risk of complications, achieve early activation of the patient, and reduce the time of medical and social rehabilitation.
Professor Galina N. Maslyakova (to the 65th birth anniversary)
Authors: Navolokin Nikita A. , Mylnikov Artyom M. , Bucharskaya Alla B. , Popkov Vladimir M.
Published: July 2023

The article presents the professional biography of the famous scientist-pathologist, Doctor of Medicine, Professor Galina Nikiforovna Maslyakova, reflecting her activity as a scientist, teacher and organizer at Saratov State Medical University named after V. I. Razumovsky
The aggressiveness of succinate dehydrogenase subunit B-deficient chromaffin cells is reduced when their bioelectrical properties are restored by glibenclamide
Authors: Amore Francesca , Garella Rachele , Santi Alice , Guasti Daniele , Martinelli Serena , Canu Letizia , Bani Daniele , Neuzil Jiri , Maggi Mario , Squecco Roberta , Rapizzi Elena
Published: July 2023

Pheochromocytomas/paragangliomas (PPGLs) are neuroendocrine tumours, mostly resulting from mutations in predisposing genes. Mutations of succinate dehydrogenase (SDH) subunit B (SDHB) are associated with high probability of metastatic disease. Since bioelectrical properties and signalling in cancer are an emerging field, we investigated the metabolic, functional and electrophysiological characteristics in human succinate dehydrogenase subunit B (SDHB)-deficient pheochromocytoma cells. These cells exhibited reduced SDH function with elevated succinate-to-fumarate ratio and reduced intracellular ATP levels. The analysis of membrane passive properties revealed a more hyperpolarized membrane potential and a lower cell capacitance of SDHB-deficient cells compared to the parental ones. These bioelectrical changes were associated with reduced proliferation and adhesion capacity of SDHB-deficient cells. Only in SDHB-deficient cells, we also observed an increased amplitude of potassium currents suggesting an activation of ATP-sensitive potassium channels (KATP). Indeed, exposure of the SDHB-deficient cells to glibenclamide, a specific KATP inhibitor, or to ATP caused normalization of potassium current features and altered proliferation and adhesion. In this work, we show for the first time that reduced intracellular ATP levels in SDHB-deficient chromaffin cells impaired cell bioelectrical properties, which, in turn, are associated with an increased cell aggressiveness. Moreover, we first ever demonstrated that glibenclamide not only reduced the outward potassium currents in SDHB-deficient cells but increased their growth capacity, reduced their ability to migrate and shifted their phenotype towards one more similar to that of parental one.
Características y errores más frecuentes en el diagnóstico y tratamiento del dengue en un hospital del norte peruano, 2022
Authors: León Jiménez Franco Ernesto , Inga-Chero Joel Emmanuel , Mendoza-Farro Nathaly Blanca Flor , Montoya Reátegui Adriana , Dioses Díaz Karim , Cavalcanti Ramírez Sofia , Moyano Luz
Published: July 2023

Sr. Editor,
En el Perú, estamos viviendo una de las peores epidemias de dengue. Hasta junio del 2023, hubo 126 726 casos, 51% confirmados y 132 fallecidos. Piura, en el norte peruano, concentra la más alta frecuencia de fallecidos con 31,7% (1). A pesar de que la letalidad es menor al 1%, un tamizaje inadecuado de la severidad y un tratamiento conservador pueden incrementarla (2).
Reciclaje del relave en la optimización del concreto lanzado en minera Cuzcatlan, Oaxaca - México
Authors: Huaicane Mullisaca Sergio Raúl
Published: July 2023

Las compañías mineras generan relaves como producto de su tratamiento metalúrgico, cubriendo enormes cantidades de terreno, generando contaminación y peligros al ecosistema, así mismo, la optimización y el incremento de la producción minera avanza rápidamente siendo ello un factor importante y preocupante en este sector, pues, en este caso específico, se busca generar nuevas alternativas para reciclar este relave y aplicarlo en otras actividades, surgiendo una oportunidad en optimizar los costos de sostenimiento sobre todo el cemento que se utiliza para la fabricación del concreto lanzado, ya que por el elevado costo se podría aprovechar este relave como un componente del concreto. Para desarrollar este trabajo de investigación se emplearon las técnicas de recolección de data y la metodología de la observación directa, debido a que se realizaron diferentes tipos de análisis físico-mecánicos y petromineragráficos como un solo componente y en combinación con los demás elementos del concreto; los resultados fueron alentadores, se logró integrar el relave al concreto y se establecieron nuevos diseños de mezcla, así mismo, este trabajo generara líneas de investigación para continuar en la búsqueda de nuevas aplicaciones del relave en otras actividades del sector.
Pérdida de playas por acción antrópica y fenómenos geodinámicos: Miraflores - La Chira (Costa Verde), Lima-Perú
Authors: San Román Moscoso Carmen Gladys , Cabrera Carranza Carlos Francisco
Published: July 2023

El objetivo de esta investigación fue describir la actual problemática generada por la acción antrópica y los fenómenos geodinámicos causantes de la pérdida de playas arenosas en el tramo Miraflores - La Chira. (Costa Verde), Lima. Metodológicamente el estudio consistió en la elaboración del mapa geodinámico y las secciones transversales a escala 1/5000, dirigida al diagnóstico de los riesgos geológicos junto con el análisis sedimentológico, enfocado en comprender los aspectos generales de la dinámica de erosión, transporte, depositación y el efecto humano asociado. Asimismo, para poder estimar la modificación del perfil de las playas y las zonas más vulnerables se tomó en cuenta las fotos aéreas del año 1960 comparadas con las recientes. Finalmente, mediante la interpretación del índice de vulnerabilidad se obtuvo una valoración de 0,38 y 15,12 que corresponde a la categoría de nivel moderado en ambas playas. Se concluye que el papel del humano es preponderante en la alteración de las geoformas.
Gestión del conocimiento con plataforma web sobre formación y mercado laboral en el interés profesional de los jóvenes de un CETPRO
Authors: Luque Ticona Dikxon Angel , Escobedo Bailón Frank
Published: July 2023

En el último lustro se dio importante atención a la creación del conocimiento para compartir y aplicarlos en bien de las organizaciones, generando información y con ayuda de las tecnologías se encamina la gestión de su conocimiento. Una experiencia interesante se realizó recopilando datos claves que disponen diversas instituciones del estado, generando información relevante organizada y sistematizada en una plataforma web para conocimiento de los jóvenes o público en general en la toma de decisiones respecto con su interés profesional. El año 2015 se lanzó la plataforma “Ponte en carrera” que ayuda a jóvenes cuya información disponible hasta ese momento era limitada y hasta empírica y que esta plataforma presenta información para conocimiento sobre las carreras profesionales, inversión y más detalles sobre la educación superior en sus diversas ofertas formativas, combinado con la información del mercado laboral, como los ingresos remunerativos de los profesionales declarados formalmente, dando idea sobre los retornos de la formación, constituyendo un aporte significativo en el servicio de orientación vocacional desde el estado. En este estudio comprobamos si la plataforma web apoya la gestión de conocimiento de un grupo de jóvenes de un Centro Educativo Técnico Productivo, sobre su interés profesional.
Heurística de Intercambio 2Opt Best Improvement_r y Nivel de Eficacia de las soluciones del Problema del Agente Viajero Simétrico
Authors: Astoquillca-Yaranga David J. , Berger-Vidal Esther
Published: July 2023

En esta investigación se desarrolló un algoritmo híbrido denominado VMC_2OptBI_r, que a partir de la solución inicial construida bajo el pensamiento del Vecino más Cercano se buscó mejorar el criterio de búsqueda de soluciones aplicado por la Heurística de Intercambio 2Opt basada en una política de intercambio de nodos denominada Best Improvement (BI) e introduciendo un factor adicional “1+r” al criterio para realizar los intercambios 2Opt. El factor “1+r” permite modificar ligeramente la selección de nodos a intercambiar provocando así la exploración de nuevas soluciones. Para medir el nivel de eficacia del nuevo algoritmo se seleccionaron instancias del problema del agente viajero simétrico de TSPLIB, las cuales en primer lugar se compararon con sus versiones básicas: El Vecino más Cercano (VMC) y el VMC_2OptBI; luego se compararon con las soluciones de los algoritmos SCA_2Opt, SCA_2Opt_r, donde se comparó con las soluciones de cuatro metaheurísticas publicadas en artículos recientes (2019-2022). Los resultados mostraron que las soluciones obtenidas por el nuevo algoritmo VMC_2OptBI_r alcanzaron un nivel de eficacia de 100% con respecto al VMC, VMC_2OptBI, SCA_2Opt, un valor mayor al 81% con respecto al SCA_2Opt_r y un rango entre el 11% al 88% con respecto a las cuatro metaheurísticas revisadas para las instancias comparadas.
Writing a Letter to One’s Muse: Genre memory and epistolography in Carl August Thielo’s Enveloppens eller Saloppens forunderlige Hændelser (1763)
Authors: Huber Patrizia
Published: July 2023

Epistolary texts are often incorporated into 18th-century prose literature, but only rarely do they self-referentially discuss intertextuality as the mimesis of memory (Neumann 2005; 2008). Carl August Thielo’s “comic novel” uses a letter to the Muse to juxtapose a writer’s reliance on literary memoria and the demand for innovation.Drawing on Mikhail M. Bakhtin’s (1984) term “genre memory,” this paper examines the relationship between memory, generic hybridity and epistolography. Genre memory describes how, through the process of “novelization,” genres are incorporated and contemporised by the novel. Creative genre memory drives innovation by giving the most archaic generic elements a voice in narration and by establishing a ground for their hybrid interplay, thus producing a semantic surplus. By connecting this approach to epistolography, generic hybridity is illustrated as a product of material and narrative practices.In lieu of a preface to the reader, Thielo’s text begins with a Muse letter asking for assistance with the poetic work. This opens a discussion of generic differences and similarities, as well as the workings of intertextuality. At the same time, the engagement of texts with literary history is visualised via addresses to a mythical being belonging to literature’s memoria. Hence, the Muse letter depicts how poetical inventio builds on intertextuality to spark inspiration, thereby materialising the otherwise invisible, but crucial stage of writing before writing.This article serves to elaborate a first understanding of novelised epistolography and its potential for literary memory studies, which emphasises material and paratextual aspects over purely linguistic elements.
Minnenas magiska lykta: Om Ingmar Bergmans berättelse Laterna magica
Authors: Almer Johan
Published: July 2023

Laterna magica (1987) is the first book Ingmar Bergman (1918–2007) published whose content was not intended to be developed into film or theater. This autobiographical book has often been used in research as a reference in various contexts concerning Bergman’s life and art. From a research point of view, however, it is difficult to use the memory book as evidence for facts or truths, as there are many examples of it simply being fiction. It is therefore interesting today to read Laterna magica as a work of art in its own right and thus perhaps find a different “truth” than the one about Ingmar Bergman’s life. For his story of himself, Bergman has very consciously chosen a literary form that structures personal memories interspersed with more contemporary events. What memories then does his literary laterna magica show and what do they mean? Why are memories and events structured in a certain way? Is there any unity in the total of more than a hundred memory images in various forms that the book consists of? My reading of Laterna magica takes a point of departure in Adriana Cavarero’s (2000) theory of the “narrative self.” In Laterna magica the narrative self creates an identity through the story that consists of the merged memory images. It then becomes a story where Bergman’s narrative self is looking for answers to the question “who am I?” The reading of the “autobiography” also assumes that it is a literary work. Thus, the story of the magical lantern of memories can be analyzed as a literary composition where staging and truth-seeking are two important concepts.
Memories for the Future? An Ecocritical Reading of Andri Snær Magnason’s On Time and Water. A History of Our Future (2019)
Authors: Mose Gitte
Published: July 2023

Andri Snær Magnason’s On Time and Water. A History of Our Future, categorized as a novel when nominated for the Nordic Literary Prize in 2020, is a unique contribution to cli-fi literature and the understanding of climate change. A generic hybrid of autobiography, stories, myths, family- and Icelandic history and culture interwoven with references to international cultures, scientific discussions and evidence-based material, the novel spans times and places and addresses the future. Applying theories from ecocriticism and memory studies, the article explores how the compositional complexity of the book, including its mental time travels, contributes to the production of images of the future.
Skandinaviske studier og geopolitik: IASS og den kolde krig
Authors: Jelsbak Torben
Published: July 2023

The foundation stone for the creation of IASS was laid at the First International Conference on Scandinavian Studies which took place at the University of Cambridge, England, in July 1956. Few months later, the world woke up to the news of the Soviet invasion in Budapest on November 4th, a defining moment in the history of the Cold War, which sent political shock waves and a flow of nearly a quarter-million Hungarian refugees to Western Europe. But how did this tense political situation affect the emerging field of international Scandinavian studies? Drawing on the vast literature of published proceedings from IASS conferences and personal interviews with members of the organization, this article examines how the Cold War geopolitical conflict between the communist East and the capitalist West left its imprint on the activities of IASS in the period from 1956 until the Fall of the Berlin Wall and the dissolution of the Soviet Union in 1989/1991.
ГЛОБАЛЬНЕ ПОЗИЦІОНУВАННЯ КИТАЙСЬКОЇ ЕКОНОМІКИ: БЕЗПЕКОВИЙ АСПЕКТ
Authors: СІДЕНКО Володимир
Published: July 2023

Досліджені зміни в глобальному позиціонуванні китайської економіки стали результатом визначних і тривалих успіхів країни в забезпеченні високої динаміки розвитку економіки, досягнення кардинальних структурних змін і високого рівня міжнародної конкурентоспроможності, який дає можливість Китаю кинути прямий виклик позиціям провідних центрів світової економіки, представленим США і ЄС, і претендувати на роль альтернативного центру формування глобального порядку. Це зумовлює істотне загострення конкурентної боротьби і суперечностей між Китаєм і Заходом, створює підґрунтя для загальної глобальної дестабілізації.
Загострення глобальної конкуренції між Китаєм і провідними центрами Заходу веде до поширення обмежувальних торговельних та інвестиційних заходів у низці важливих сфер економіки, підвищує рівень комерційних та інвестиційних ризиків, зумовлює руйнування глобальних ланцюгів створення вартості й посилює прагнення багатонаціональних компаній до релокації своїх виробництв за межі Китаю. У свою чергу, це стимулює процес переорієнтації китайської політики економічного розвитку на якісні параметри і перехід від надмірної орієнтації на експорт до більш збалансованого розвитку економіки. Водночас це заохочує його до просування альтернативної моделі глобалізації на основі концепції «єдиної долі людства» в поєднанні із задіянням потужного механізму інвестиційного і фінансового проникнення в різні регіони світу, формування своєї зони економічного і політичного впливу. Подальші глобальні перспективи Китаю багато в чому залежатимуть від його здатності стати реальним світовим технологічним лідером в умовах швидкого поширення новітніх інформаційних, біо- і нанотехнологій.
Суттєве загострення конфліктів Китаю із Заходом створюватиме несприятливе середовище для розвитку світової економіки, вирішення ключових глобальних проблем людства, породжуватиме низку глобальних безпекових ризиків. До того ж, це потребуватиме активізації зусиль щодо знаходження нових інституційних форматів для забезпечення балансу інтересів серед ключових учасників світового господарства.
СОЦІО-ЕКОЛОГІЧНІ НАСЛІДКИ АГРОПРОДОВОЛЬЧОЇ СПЕЦІАЛІЗАЦІЇ УКРАЇНИ: ПРИЧИНИ І СПОСОБИ ЇХ УСУНЕННЯ
Authors: МОЛДАВАН Любов
Published: July 2023

Міжнародні організації, світова наукова спільнота відзначають наростання екологічних процесів, пов’язаних із сільськогосподарською діяльністю. Зокрема, визнається негативний вплив на екологію природних ресурсів аграрного сектору глибоко спеціалізованого (монокультурного) виробництва, яке посилює деградацію угідь. Втрати від ґрунтовтоми – супутника монокультури становлять майже 25 % світового врожаю. У документах ООН ідеться не лише про екологічні, а й про соціальні втрати монокультурного виробництва: зменшення зайнятості сільського населення, посилення бідності, погіршення харчування тощо.
Проаналізовано процеси формування в Україні глибоко спеціалізованого, з ознаками монокультурного, землеробства, зональний аспект якого дозволяє виявити його негативні екологічні й соціальні наслідки. Перехід у Степовій зоні на вирощування ґрунтовиснажливих і гумусопоглинаючих зернових і соняшнику, які зайняли більш як 93 % посівних площ, витіснивши пари і багаторічні трави, обумовив посилення ерозії, якою нині вражено 60–80 % сільгоспугідь, дегуманізацію ґрунтів (дефіцит гумусу сягає 600 кг/га), значне скорочення тваринництва, зменшення споживання населенням молока і молокопродуктів, зниження калорійності середньодобового раціону, ліквідацію робочих місць у сільськогосподарському виробництві тощо. Зазначені процеси притаманні східним регіонам Лісостепу і, хоча й меншою мірою, іншим регіонам країни. У цілому по Україні знижується якість харчування, зростає імпортозалежність за певними видами продовольчих товарів, витіснених з виробництва в результаті глибокої спеціалізації. Для упередження подальшого розвитку цих та інших негативних процесів обґрунтовано безальтернативність переходу від глибоко спеціалізованого монокультурного сільського господарства до агроекологічного плодозмінного в симбіозі з тваринництвом. Запропоновано механізми переходу до даного типу землеробства з урахуванням теоретичних засад проблеми і досвіду її розв’язання в західноєвропейських та інших країнах, що дозволить призупинити деградацію і забезпечити зростання продуктивності сільськогосподарських угідь, зберегти продовольчий суверенітет країни та її сільський трудовий потенціал.
Life and Career Skills in Mathematics Learning for High School Students in Indonesia: The Perspectives of Teachers and Students
Authors: Miftah Ramdani , Kurniawati Lia , Herman Tatang , Juandi Dadang , Maulida Aya Shofia
Published: July 2023

Students need to possess the right life and career skills to face future life challenges. Therefore, this study aims to determine the effect of the life skills of mathematics teachers on high school students in Indonesia. Data were collected from 190 mathematics teachers and 627 high school students through questionnaires consisting of 15 and 45 statements for both parties. The data collected were analyzed using the Structural Equation Modeling (SEM) method and the Smart-PLS v.3.2.9 software. The results showed that the understanding of mathematics teachers (77.50%) and high school students (83%) concerning life and career skills is in a good category. Meanwhile, their life skills are in a low category due to teachers’ difficulties in translating life and career skills in planning and implementing mathematics learning. This means that the mathematics learning methods developed by teachers do not explore students' potential. Moreover, teachers’ life skills did not significantly affect each student's indicator. Only two indicators had a medium effect, namely responsibility and flexibility on leadership as well asadaptability and flexibility on initiative and self-direction