bluuebunny/crossref_metadata_2025 huggingface dataset:
Activation of CD4+ T Cell–Derived Cannabinoid Receptor 2 Signaling Exacerbates Sepsis via Inhibiting IL-10
Authors: Chen Jincheng , Wang Fuxiang , Zhang Su , Lin Qiao , Xu Hui , Zhu Tengfei , Peng Ling , Cen Fulan , Li Fang , Wang Zhaoqin , Feng Carl G , Yin Zhinan , Liu Yingxia , Zhang Guoliang
Published: July 2022

The cannabinoid receptor 2 (CB2) is a receptor mainly expressed in immune cells and believed to be immunosuppressive in infective or inflammatory models. However, its role in sepsis has not been fully elucidated. In this study, we delineate the function and mechanism of CB2 in the cecal ligation and puncture–induced septic model in mice. The activation of CB2 signaling with HU308 led to decreased survival rates and more severe lung injury in septic mice, and lower IL-10 levels in peritoneal lavage fluid were observed in the CB2 agonist group. The mice with conditional knockout of CB2-encoding gene CNR2 in CD4+ T cells (CD4 Cre CNR2fl/fl) improved survival, enhanced IL-10 production, and ameliorated pulmonary damage in the sepsis model after CB2 activation. In addition, double-knockout of the CNR2 gene (Lyz2 Cre CD4 Cre CNR2fl/fl) decreased the susceptibility to sepsis compared with Lyz2 Cre CNR2fl/fl mice. Mechanistically, the blockade of IL-10 with the anti–IL-10 Ab abolished its protection in CD4 Cre CNR2fl/fl mice. In accordance with the animal study, in vitro results revealed that the lack of CNR2 in CD4+ cells elevated IL-10 production, and CB2 activation inhibited CD4+ T cell–derived IL-10 production. Furthermore, in the clinical environment, septic patients expressed enhanced CB2 mRNA levels compared with healthy donors in PBMCs, and their CB2 expression was inversely correlated with IL-10. These results suggested that the activation of CD4+ T cell–derived CB2 increased susceptibility to sepsis through inhibiting IL-10 production.
Extracellular Nucleotides and Histamine Suppress TLR3- and RIG-I–Mediated Release of Antiviral IFNs from Human Airway Epithelial Cells
Authors: Kountz Timothy S , Biyasheva Assel , Schleimer Robert P , Prakriya Murali
Published: July 2022

Respiratory viruses stimulate the release of antiviral IFNs from the airway epithelium. Previous studies have shown that asthmatic patients show diminished release of type I and type III IFNs from bronchial epithelia. However, the mechanism of this suppression is not understood. In this study, we report that extracellular nucleotides and histamine, which are elevated in asthmatic airways, strongly inhibit release of type I and type III IFNs from human bronchial airway epithelial cells (AECs). Specifically, ATP, UTP, and histamine all inhibited the release of type I and type III IFNs from AECs induced by activation of TLR3, retinoic acid–inducible gene I (RIG-I), or cyclic GMP-AMP synthase–STING. This inhibition was at least partly mediated by Gq signaling through purinergic P2Y2 and H1 receptors, but it did not involve store-operated calcium entry. Pharmacological blockade of protein kinase C partially reversed inhibition of IFN production. Conversely, direct activation of protein kinase C with phorbol esters strongly inhibited TLR3- and RIG-I–mediated IFN production. Inhibition of type I and type III IFNs by ATP, UTP, histamine, and the proteinase-activated receptor 2 (PAR2) receptor agonist SLIGKV also occurred in differentiated AECs grown at an air–liquid interface, indicating that the suppression is conserved following mucociliary differentiation. Importantly, histamine and, more strikingly, ATP inhibited type I IFN release from human airway cells infected with live influenza A virus or rhinovirus 1B. These results reveal an important role for extracellular nucleotides and histamine in attenuating the induction of type I and III IFNs from AECs and help explain the molecular basis of the suppression of IFN responses in asthmatic patients.
Type I IFN Signaling Is Essential for Preventing IFN-γ Hyperproduction and Subsequent Deterioration of Antibacterial Immunity during Postinfluenza Pneumococcal Infection
Authors: Palani Sunil , Bansal Shruti , Verma Atul K , Bauer Christopher , Shao Shengjun , Uddin Md Bashir , Sun Keer
Published: July 2022

Postinfluenza bacterial pneumonia is a significant cause of hospitalization and death in humans. The mechanisms underlying this viral and bacterial synergy remain incompletely understood. Recent evidence indicates that influenza-induced IFNs, particularly type I IFN (IFN-I) and IFN-γ, suppress antibacterial defenses. In this study, we have investigated the relative importance and interplay of IFN-I and IFN-γ pathways in influenza-induced susceptibility to Streptococcus pneumoniae infection. Using gene-deficient mouse models, as well as in vivo blocking Abs, we show that both IFN-I and IFN-γ signaling pathways contribute to the initial suppression of antibacterial immunity; however, IFN-γ plays a dominant role in the disease deterioration, in association with increased TNF-α production and alveolar macrophage (AM) depletion. We have previously shown that IFN-γ impairs AM antibacterial function and thereby acute bacterial clearance. The findings in this study indicate that IFN-γ signaling also impairs AM viability and αβ T cell recruitment during the progression of influenza/S. pneumoniae coinfection. Macrophages insensitive to IFN-γ mice express a dominant-negative mutant IFN-γR in mononuclear phagocytes. Interestingly, macrophages insensitive to IFN-γ mice exhibited significantly improved recovery and survival from coinfection, despite delayed bacterial clearance. Importantly, we demonstrate that IFN-I receptor signaling is essential for preventing IFN-γ hyperproduction and animal death during the progression of postinfluenza pneumococcal pneumonia.
At Critically Low Antigen Densities, IgM Hexamers Outcompete Both IgM Pentamers and IgG1 for Human Complement Deposition and Complement-Dependent Cytotoxicity
Authors: Oskam Nienke , Ooijevaar-de Heer Pleuni , Derksen Ninotska I L , Kruithof Simone , de Taeye Steven W , Vidarsson Gestur , Reijm Sanne , Kissel Theresa , Toes René E M , Rispens Theo
Published: July 2022

IgM is secreted as a pentameric polymer containing a peptide called the joining chain (J chain). However, integration of the J chain is not required for IgM assembly and in its absence IgM predominantly forms hexamers. The conformations of pentameric and hexameric IgM are remarkably similar with a hexagonal arrangement in solution. Despite these similarities, hexameric IgM has been reported to be a more potent complement activator than pentameric IgM, but reported relative potencies vary across different studies. Because of these discrepancies, we systematically investigated human IgM-mediated complement activation. We recombinantly generated pentameric and hexameric human IgM (IgM+J and IgM−J, respectively) mAbs and measured their ability to induce complement deposition and complement-dependent cytotoxicity when bound to several Ags at varying densities. At high Ag densities, hexameric and pentameric IgM activate complement to a similar extent as IgG1. However, at low densities, hexameric IgM outcompeted pentameric IgM and even more so IgG1. These differences became progressively more pronounced as antigenic density became critically low. Our findings highlight that the differential potency of hexameric and pentameric IgM for complement activation is profoundly dependent on the nature of its interactions with Ag. Furthermore, it underscores the importance of IgM in immunity because it is a more potent complement activator than IgG1 at low Ag densities.
Restoration of Follicular T Regulatory/Helper Cell Balance by OX40L–JAG1 Cotreatment Suppresses Lupus Nephritis in NZBWF1/j Mice
Authors: Kumar Prabhakaran , Balakrishnan Sivasangari , Surendra Lele Swarali , Setty Suman , Dhingra Shaurya , Epstein Alan L , Prabhakar Bellur S
Published: July 2022

Class-switched antinuclear autoantibodies produced by T follicular helper (TFH) cell–dependent germinal center (GC) B cell response play an essential pathogenic role in lupus nephritis (LN). The role of T follicular regulatory (TFR) cells, an effector subset of CD4+Foxp3+ T regulatory cells (Tregs), which are specialized in suppressing TFH-GC response and Ab production, remains elusive in LN. Contrasting reports have shown increased/reduced circulating TFR cells in human lupus that might not accurately reflect their presence in the GCs of relevant lymphoid organs. In this study, we report a progressive reduction in TFR cells and decreased TFR/TFH ratio despite increased Tregs in the renal lymph nodes of NZBWF1/j mice, which correlated with increased GC-B cells and proteinuria onset. Cotreatment with soluble OX40L and Jagged-1 (JAG1) proteins increased Tregs, TFR cells, and TFR/TFH ratio, with a concomitant reduction in TFH cells, GC B cells, and anti-dsDNA IgG Ab levels, and suppressed LN onset. Mechanistic studies showed attenuated TFH functions and diminished GC events such as somatic hypermutation and isotype class-switching in OX40L-JAG1–treated mice. RNA sequencing studies revealed inhibition of hypoxia-inducible factor 1-α (HIF-1a) and STAT3 signaling in T conventional cells from OX40L-JAG1–treated mice, which are critical for the glycolytic flux and differentiation into TFH cell lineage. Therefore, the increased TFR/TFH ratio seen in OX40L-JAG1–treated mice could involve both impaired differentiation of TFH cells from T conventional cells and expansion of TFR cells. We show a key role for GC-TFR/TFH imbalance in LN pathogenesis and how restoring homeostatic balance can suppress LN.
Long Live the Plasma Cell: The Basis of Sustained Humoral Immunity
Authors: Koutsakos Marios , Ellebedy Ali H
Published: July 2022

This Pillars of Immunology article is a commentary on “Humoral immunity due to long-lived plasma cells,” a pivotal article written by M. K. Slifka, R. Antia, J. K. Whitmire, and R. Ahmed, and published in Immunity, in 1998. https://pubmed.ncbi.nlm.nih.gov/9529153/. The Journal of Immunology, 2022, 209: 3–4.
Cutting Edge: T Cell Responses to B.1.1.529 (Omicron) SARS-CoV-2 Variant Induced by COVID-19 Infection and/or mRNA Vaccination Are Largely Preserved
Authors: Jergović Mladen , Coplen Christopher P , Uhrlaub Jennifer L , Beitel Shawn C , Burgess Jefferey L , Lutrick Karen , Ellingson Katherine D , Watanabe Makiko , Nikolich-Žugich Janko
Published: July 2022

Several studies have demonstrated that the SARS-CoV-2 variant-of-concern B.1.1.529 (Omicron) exhibits a high degree of escape from Ab neutralization. Therefore, it is critical to determine how well the second line of adaptive immunity, T cell memory, performs against Omicron. To this purpose, we analyzed a human cohort (n = 327 subjects) of two- or three-dose mRNA vaccine recipients and COVID-19 postinfection subjects. We report that T cell responses against Omicron were largely preserved. IFN-γ–producing T cell responses remained equivalent to the response against the ancestral strain (WA1/2020), with some (∼20%) loss in IL-2 single or IL-2+IFN-γ+ polyfunctional responses. Three-dose vaccinated participants had similar responses to Omicron relative to post–COVID-19 participants and exhibited responses significantly higher than those receiving two mRNA vaccine doses. These results provide further evidence that a three-dose vaccine regimen benefits the induction of optimal functional T cell immune memory.
Spinal Cord Injury Impairs Lung Immunity in Mice
Authors: Mifflin Katherine A , Brennan Faith H , Guan Zhen , Kigerl Kristina A , Filous Angela R , Mo Xiaokui , Schwab Jan M , Popovich Phillip G
Published: July 2022

Pulmonary infection is a leading cause of morbidity and mortality after spinal cord injury (SCI). Although SCI causes atrophy and dysfunction in primary and secondary lymphoid tissues with a corresponding decrease in the number and function of circulating leukocytes, it is unknown whether this SCI-dependent systemic immune suppression also affects the unique tissue-specific antimicrobial defense mechanisms that protect the lung. In this study, we tested the hypothesis that SCI directly impairs pulmonary immunity and subsequently increases the risk for developing pneumonia. Using mouse models of severe high-level SCI, we find that recruitment of circulating leukocytes and transcriptional control of immune signaling in the lung is impaired after SCI, creating an environment that is permissive for infection. Specifically, we saw a sustained loss of pulmonary leukocytes, a loss of alveolar macrophages at chronic time points postinjury, and a decrease in immune modulatory genes, especially cytokines, needed to eliminate pulmonary infections. Importantly, this injury-dependent impairment of pulmonary antimicrobial defense is only partially overcome by boosting the recruitment of immune cells to the lung with the drug AMD3100, a Food and Drug Administration–approved drug that mobilizes leukocytes and hematopoietic stem cells from bone marrow. Collectively, these data indicate that the immune-suppressive effects of SCI extend to the lung, a unique site of mucosal immunity. Furthermore, preventing lung infection after SCI will likely require novel strategies, beyond the use of orthodox antibiotics, to reverse or block tissue-specific cellular and molecular determinants of pulmonary immune surveillance.
The All-Encompassing Importance of Innate Immunity
Authors: Ting Jenny P-Y
Published: July 2022

In their AAI President’s Addresses reproduced in this issue, Jeremy M. Boss, Ph.D. (AAI ’94; AAI President 2019–2020) and Jenny P.-Y. Ting, Ph.D. (AAI ’97; AAI President 2020–2021) welcomed attendees to the AAI annual meeting, Virtual IMMUNOLOGY2021™. Due to the SARS-CoV-2 pandemic and the cancellation of IMMUNOLOGY2020™, Dr. Boss and Dr. Ting each presented their respective President’s Address to open the meeting.
The Aronson–Bénilan estimate in Lebesgue spaces
Authors: Schmidtchen Markus , Bevilacqua Giulia , Perthame Benoît
Published: July 2022

In a celebrated three-page-long paper in 1979, Aronson and Bénilan obtained a remarkable estimate on second-order derivatives for the solution of the porous media equation. Since its publication, the theory of porous medium flow has expanded relentlessly with applications including thermodynamics, gas flow, and groundwater flow, as well as ecological population dynamics. The purpose of this paper is to clarify the use of recent extensions of the Aronson and Bénilan estimate in

L^p

spaces and of some modifications and improvements, as well as to show certain limitations
of their strategy.
Secular Growth Trends in Early Childhood—Evidence from Two Low-Income Birth Cohorts Recruited over a Decade in Vellore, India
Authors: Koshy Beena , Karthikeyan Arun S. , Mohan Venkata Raghava , Bose Anuradha , John Sushil , Kang Gagandeep
Published: July 2022

Stunting and extreme poverty are considered significant risk factors impacting child development in low-and-middle-income countries. We used two birth cohorts recruited 8–9 years apart in urban low-income (slum) settings in Vellore, south India and analyzed secular growth trends and their predictors. In the rotavirus cohort recruited between 2002 and 2003, 373 children completed the 3-year follow-up. “The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development” (MAL-ED) cohort recruited between 2010 and 2012 had 215 children completing follow-up. The MAL-ED cohort had better socio-economic status (SES) markers and mothers were better educated compared with the previous cohort. Children in the MAL-ED cohort had less stunting at 1, 2, and 3 years of age. The linear mixed effects model evaluating linear growth during the first 3 years of age showed that low birth weight and being a female child were associated with stunting in both cohorts. There was no association between SES and stunting in the rotavirus cohort, whereas SES was associated with linear growth in the MAL-ED cohort. Future studies could incorporate nutritional and nonnutritional interventions in vulnerable populations to evaluate their effect on birth weight as well as early childhood stunting.
Teaching and Learning during COVID-19 Crisis: Faculty Preparedness and Factors Influencing the Use of E-learning Platform at the College of Medicine and Health Sciences, University of Rwanda
Authors: Nyiringango Gerard , Umubyeyi Benoite , Nyirazigama Alice , Mukankusi Juliet , Mukeshimana Madeleine , Mugarura John , Bagirisano Justine , Kayiranga Dieudonne , Ryamukuru David , Igikundiro Christine , Rutayisire Reverien , Niyikiza Eric M. , Adejumo Oluyinka
Published: July 2022

BackgroundTowards the beginning of 2020, the COVID-19 pandemic spread worldwide and caused many schools to close. Many educational institutions transitioned from traditional face-to-face or blended to a total e-learning approach. The University of Rwanda rapidly shifted from a blended teaching and learning approach to a total e-learning approach. Thus,this study assessed the faculty preparedness and the factors influencing the use of e-learningplatforms at the College of Medicine and Health Sciences.MethodsThe study used a cross-sectional design. A web self-administered questionnaire was used to collect data from 450 CMHS faculty from June to July 2020, with a response rate of 34.4% (n=155). SPSS was used to describe nominal variables with frequencies and percentages. Similarly, continuous variables were analyzed by calculating median and interquartile ranges. The Chi-Square and Man-Whitney tests were also computed using SPSS.ResultsThe majority of participants (93.7%) started using the e-learning approach, and 92.4% attended e-learning training. The top motivator for e-learning use was a personal interest in technology use (93.3%) and the leading barrier to using e-learning was the concern about access to students (77.1%).ConclusionThis study found that faculty preparedness was significantly associated with e-learning use. The leading motivator and barriers were a personal interest in technology use and concern about access to students, respectively.Rwanda J Med Health Sci 2022;5(2):189-202
VARIABLES SOCIODEMOGRÁFICAS Y NIVEL DE RIESGO EN MUJERES VÍCTIMAS DE VIOLENCIA PSICOLÓGICA EN PUNO, 2020
Authors: Mamani Portugal Gina Elizabeth
Published: July 2022

El objetivo de la investigación fue determinar la relación entre las variables sociodemográficas y el nivel de riesgo en mujeres víctimas de violencia psicológica por su pareja o ex pareja en la provincia de Puno, 2020. Metodológicamente fue de tipo cuantitativa; con diseño descriptivo, correlacional, no experimental, prospectiva y transversal. La población y muestra estuvo conformada por 89 mujeres, que fueron atendidas en el Centro Emergencia Mujer Comisaría Puno. Se obtuvieron como resultados que; el 53.93% tenía nivel de riesgo leve; de las mujeres con riesgo leve, el 26.97% tenía superior completa, el 37.08% eran casadas o convivientes, el 26.97% tenía igual grado de instrucción que la pareja o ex pareja. Se concluye que, el nivel de riesgo no está altamente presente en la población; y no existe relación significativa entre la mayoría de las variables sociodemográficas y el nivel de riesgo, aunque existe significativa relación entre la diferencia en grado de instrucción y el nivel de riesgo.
CIBERACOSO ESCOLAR EN CONTEXTOS DE AISLAMIENTO SOCIAL
Authors: Oblea De La Cruz Arnold Lowis
Published: July 2022

El presente estudio tuvo como objetivo principal describir las características del ciberacoso escolar en contextos de aislamiento social. Este fue descriptivo simple, donde se pudo realizar un análisis de manera exhaustiva de diversas bibliografías. La investigación se organizó en 4 capítulos. Se pudo evidenciar que los rasgos de los actores principales del ciberacoso eran: El acosador, la víctima y el observador o llamado también testigo, este último juega un papel importante en la conducta del acosador. Además, se precisa las conductas en el que se desenvuelve el agresor como: Los insultos electrónicos, el hostigamiento, la suplantación, el desvelamiento y sonsacamiento, la exclusión y ostracismo, la ciber persecución y por último y más peligroso el happy slapping. Asimismo, se han identificado los factores de riesgo y protección las cuales tienen un comportamiento antagónico y relacionado a la vez, como los factores personales, los relacionados a la familia, a la escuela y la tecnología. Ante ello en el Perú se siguen trabajando las normas legales para el ciberacoso como el Decreto Legislativo N° 1410 acoso, donde solo se ha estipulado en unos de sus artículos 151 las penalidades para el acoso en uso de las herramientas de tecnológicas; lo que conlleva a seguir profundizando en el tema para reducir las incidencias en nuestro país.
The State of Vitamin D Supplement Use and Knowledge Levels of Mothers With 0-12 Month-Old Infants
Authors: SEREMET KÜRKLÜ Nilgün , SUNA Gülen , KAMARLI ALTUN Hülya , KARAÇİL ERMUMCU Merve Şeyda
Published: July 2022

Aim: This study aimed to understand the knowledge and awareness of mothers about vitamin D and to observe their practices regarding the use of vitamin D for themselves during pregnancy and for their infants after birth.

Material and Method: This descriptive study was conducted between July and November 2021 with a total of 818 mothers between the ages of 18 and 48 with 0-12 months old infants via a web-based survey.

Results: The majority of mothers were between the ages of 25 and 29 and had a university degree (40.2% and 52.3%, respectively). 65.6% of the mothers stated that they used vitamin D supplements during pregnancy. Most of the infants were given vitamin D supplementation immediately or within 15 days after birth. 91.9% were still using vitamin D supplements daily (3.3 ± 1.30 drops). The majority of mothers had sufficient knowledge about the functions of vitamin D and the diseases that can occur in its deficiency.

Conclusion: This study shows that most mothers comply with the time and amount of vitamin D use recommended for themselves and their infants in "Vitamin D Supplementation Programs", and that they are well-informed about vitamin D supplementation.
Apresentação do Dossiê - “A Privatização da Educação Brasileira: ações mercantis e financeiras na definição das políticas públicas”
Authors: Lelis Ùrsula Adelaide , Vieira Silva Maria
Published: July 2022

Incursões privadas na educação brasileira, historicamente recorrentes, vêm alçando espaços cada vez mais significativos, constituindo expressivas capilaridade e vigência após a reforma do Estado brasileiro, nos anos 1990, quando intensificaram-se as propostas e ações privadas e público-privadas no âmbito das políticas públicas educacionais, de natureza e contornos cada vez mais acentuados e heterogêneos.
Parcerias público-privadas, ensino médio e ensino profissionalizante no Brasil: o caminho da privatização do currículo escolar
Authors: Dos Santos Pereira Edirleine , Adelaide de Lélis Úrsula
Published: July 2022

Analisar os aspectos políticos, econômicos e sociais que perpassaram a materialização das parcerias público-privadas, na história dos Ensinos Médio e Profissional, no Brasil, de 1960 a 2020 é o objetivo deste texto. Trata-se de um estudo bibliográfico, a partir de análises críticas sobre o objeto em foco, à luz da perspectiva dialética, tendo como referência principal os estudos de Shiroma, Moraes e Evangelista (2011), Saviani (2008) e Nascimento (2007). Constatou-se que a responsabilidade pelos Ensinos Médio e Profissional, nesse período, foi sendo transferida para a esfera privada, reduzindo a educação para o trabalho à preparação de força de trabalho, em atendimento às demandas do setor produtivo. Por sua vez, pela via dessas parcerias, o setor empresarial determina, cada vez mais, as políticas educacionais, especialmente as que definem o currículo escolar.
A reforma empresarial em Minas Gerais: rumo à privatização da educação pública
Authors: Ferraz Pereira Maria Simone , De Fátima valente Lucia , Aparecida Franco Freitas Vanyne
Published: July 2022

O presente trabalho objetiva analisar propostas e ações para educação mineira, no Governo de Romeu Zema Neto (2019-2022), relacionadas a melhoria da qualidade da educação em Minas Gerais. Para tal finalidade, parte da seguinte indagação: em que grau essas propostas e ações podem conduzir à privatização da educação pública no Estado? Na busca de respostas, realizou-se uma pesquisa bibliográfica e documental, bem como uma análise do documento “Liberdade Ainda que Tardia” e de outros documentos e matérias veiculadas nos portais oficiais do governo, como “Agência Minas” e “Transparência”. Nas ações implantadas é possível identificar uma lógica gerencialista que busca atender às demandas políticas, econômicas e educacionais, pautada em um paradigma mercadológico de minimização do papel do Estado frente às demandas sociais, potencializando cada vez mais a tríade responsabilização, meritocracia e privatização.
A Smart Greenhouse Monitoring System
Authors: More Shweta Dhuraji , Nandedkar Shilpa , Kodgire Shilpa
Published: July 2022

The system proposed in this paper is an advanced result for covering the all conditions at a particular place and making the information visible anywhere in the world. The technology behind this is the Internet of Things (IoT), which is an advanced and effective result for connecting the effects to the internet and to connect the entire world of effects in a network. Then effects might be whatever like electronic widgets, detectors and automotive electronic outfits. The system deals with monitoring and controlling the environmental conditions like temperature, relative moisture and CO position with detectors and sends the information to the web runner and compass the detector data as graphical statistics. The data streamlined from the enforced system can be accessible on the internet from anywhere in the world.
Traffic Management For Cities
Authors: Pranav B. Channi  , Ayush Oswal  , Sunil Reddy  , Praveen S. Helavagol  , Akshata Patted  , Supanna S. Shirguppe
Published: July 2022

Most Urban places across the world have considerable traffic congestion, which has become a
nightmare for the locals. It is caused by incorrect traffic flagging planning, delayed flagging, and
other factors. Traffic light postponement is hard coded and independent of traffic. There is a
growing movement to automate traffic control in this way request in a precise, quick-coding
framework. This study aims to develop a robust traffic sign based on density control. When the
junction’s traffic density is detected. The flag time adjust logically. This framework contain IR
sensors.(transmitter and receiver) which will be mounted. When the vehicle approaches near to it,
start and get the flag.
Al-Ishlah Perspektif al-Qur’an
Authors: Arini Hidayat Andi
Published: July 2022

Al-Qur’an telah menyatakan dirinya sebagai kitab petunjuk yang dapat menuntun umat manusia menuju ke jalan yang benar. Selain itu, al-Qur’an juga berfungsi sebagai pemberi penjelasan terhadap segala sesuatu dan pembeda antara kebenaran dan kebatilan. Sejumlah pakar dan ulama yang berkompeten sejak awal telah melakukan penafsiran untuk mengungkap petunjuk dan penjelasan dari al-Qur’an. Namun demikian, keindahan dan kedalaman maknanya serta keragaman temanya membuat pesan-pesannya tidak pernah berkurang, apalagi habis meski telah dikaji  dari berbagai aspeknya. Dalam interaksi sosial, konflik sering kali muncul dan sulit untuk dihindari. Hal tersebut timbul karena adanya konflik kepentingan antara individu dalam masyarakat. Bahaya dan dampak yang ditimbulkan dari konflik itu sangat buruk, dapat mempengaruhi dan bahkan menghancurkan berbagai sendi-sendi kehidupan masyarakat.[1] Untuk mencegah dampak buruk tersebut, maka Al-Qur’an memerintahkan kepada pihak-pihak yang berkonflik secara langsung atau tidak, agar mengadakan al-Ishlah.
REKONTRUKSI PEMIKIRAN HERMENEUTIKA HADIS SYUHUDI ISMAIL
Authors: Umar Umar Hadi
Published: July 2022

Dalam sejarah kesarjaan hadis di Indonesi, nama Syuhudi Ismail wajib disebut. Karena beliau adalah seorang peraih doktor pertama dalam bidang ilmu hadis di Indonesia dengan karya monumentalnya “Kaedah Kesahihan Sanad Hadis: Telaah Kritis dan Tinjauan dengan Pendekatan IlmuSejarah. Sumbangan Syuhudi dalam kesarjaan hadis di Indonesia tidak hanya berkaitan dengan kritik sanad. Tapi juga berkaitan dengan cara menafsirkan hadis secara akurat yang dia sampaikan dalam pidato pengukuhan guru besarnya. Dalam tulisan ini ide utamanya tentang hadis tekstual dan kontekstual akan direkontruksi menjadi pemikiran hermeneutis hadisnya sehingga menjadi salah satu sumbangan dalam khazanah penfasfsiran hadis
Efektivitas Menghafal Al-Qur’an: Melalui Metode Elmaduri
Authors: Syaiful Anam
Published: July 2022

Penelitian ini bertujuan untuk mengkaji tentang efektivitas metode menghafal al-Qur’an dengan metode Elmaduri. Data diperoleh melalui observasi dan dokumentasi data yang valid dan dapat dipertanggungjawabkan. Metode menghafal yang digunakan di  Pondok  Pesantren  Ruqoba Al-Atsari adalah metode elmaduri. Metode elmaduri adalah ziyadah dan muroja’ah. Hasil temuan yang lain adalah efektifitas metode tahfidzul Qur’an “Elmaduri”, yaitu efektivitas berfokus pada outcome (hasil), program, atau kegiatan yang mana dinilai efektif apabila output yang dihasilkan dapat memenuhi tujuan yang diharapkan. Kelebihan metode ini adalah cepat untuk mendapatkan perolehan hafalan, karena metode menghafal yang non stop dari pagi hingga malam hari. Sedangkan kekurangan metode ini adalah karena lebih mengutamakan hafalan baru, bagi yang tidak tekun akan susah dalam murojaah, sehingga hafalannya banyak yang lupa.
The Connection on Fiber Bundles
Authors:   Department of Mathematics, Faculty of Education, Omdurman Islamic University, Omdurman, Sudan, Rahman Abdel Radi Abdel Rahman Abdel Gadir Abdel
Published: July 2022

A connection is a device that defines the concept of parallel transport on a bundle, that is identifies fibers over nearby points. Fiber bundles form are the natural mathematical framework for the gauge filed theories. Also affine connection is the most elementary type of connection, a means of parallel transfer of tangent vectors on a manifold from one point to another. In any manifold with a positive dimension there is an infinite number of the affine connection; junctions are among the simplest methods to determine the differentiation of sections of vector bundles. Our goal in this paper is to identify the concept of connection in fiber bundles. We followed the analytical historical mathematical method and we found that the connection on the fiber bundle is a smooth distribution over the total bundle area, which is of central importance in modern geometry and leads to appropriate formulas for geometry constants.
The Determinant Effect Of Financial Performance On Return On Assets (ROA) In Full-Fledged Islamic Banks In Indonesia For The 2015-2019 Period
Authors:   Asian Banking Finance and Informatics Institute, PERBANAS, Sari Ela Yuliana
Published: July 2022

The objective of this analysis is to determine the impact of Capital Adequacy Ratio (CAR), Non-Performing Financing (NPF) and Operating Income versus Operating Expenses (Biaya Operasional Pendapatan Operasional/ BOPO) on Return on Assets (ROA) on Full-Fledged Islamic Banks in Indonesia during the 2015-2019 research period. The number of samples used was four companies depending on the purpose of sampling. The technique used in data analysis includes a multi-linear regression analysis studied with EVIEW 9. The findings of the test hypotheses indicate that CAR has a negative and substantial impact on ROA. At the same time, NPF has no effect on ROA. BOPO has a negative and important effect on ROA. At the same moment, the variables of CAR, NPF and BOPO have a major impact on ROA
A Renewal Attempt at a Bill in Indonesia’s Criminal Law: A Study of the Development in the Norm of Rejang Customary Law
Authors:   Fakultas Hukum Universitas Bengkulu, Jl. WR. Supratman, Kandang Limun, Kota Bengkulu
Published: July 2022

The inventory of Rejang Customary Law norm, specifically in Bengkulu Tengah regency, in line with the Indonesia’s Law Renewal Policies. All of the way to strengthen the local wisdom, including the case resolution mechanism within National political Law, are all been stated in National Policies, started when it was stated in the Presidential Regulation of the Republic of Indonesia No. 7 Year 2005 concerning the National Medium term development plan (RPJMN) in 2004-2009, which already written to reform the law system and politic in the next five years. Therefore its necessary to conduct research on customary court, especially on customary law in Rejang community whose domiciled in Bengkulu Tengah. Some of the question that needed to be answered in this research is which forms, term, norms and reaction are there that of the Rejang Customary Law that still apply in the communities that occurs in Bengkulu Tengah regency that related to crimes against one’s dignity and life. This research is an empirical law research, which examines the law as a fact and the application of law in the Rejang society in Bengkulu Tengah regency. Regarding to crimes againts the dignity and life of a person, there are several institution of Customary Law norm with respective reaction/sanction, namely Menggomboa, Tekleseng, Tekabeak, Ngabeak, Iram Coa Berdaleak, Cido Celako, Upet, Johong Pemayo, Begaseak, Bangun Kenyayo, Cempalo Tangan, Bangun mayo, Kerineak. While customary reaction to violation of customary norms relating to the dignity and the life of a person are Minai Maaf and or Tentok Kambing, and or Tepunjung, and or kedendo, and or Tepung Tabea (Setawar Sedingin), expulsion, or signing a letter of Peace Agreement.
Lived Experiences of Teachers in Implementing Assessment Methods amid Modular Instruction: Phenomenological Study
Authors:   Undergraduate Program, Leyte Normal University, Leyte, Philippines
Published: July 2022

This phenomenological study aims to gain an in-depth understanding of the lived experiences of teachers of Juan Villablanca Memorial High School as well as the challenges they have faced and their coping mechanisms upon the implementation of their assessment methods amidst modular instruction. This research employed the phenomenological method of inquiry as the study's research design to provide a thorough description of the shared experiences of teachers. Through purposive sampling, four teachers from Juan Villablanca Memorial High School were chosen as the participants of this study and were subjected to a face to face, semi-structured interview with open-ended questions. After the data analysis, three overall themes emerged from the rich and thick descriptions from key informant interviews: (1) Experiences of Teachers; (2) Challenges faced by Teachers; and (3) Coping Mechanisms. This research is helpful to DepEd policymakers, teachers, and future educational researchers to understand the first hand experiences, challenges and coping mechanisms teachers have with the implementation of their assessment methods amid modular instruction to create policies and interventions that would address such gaps and struggles. The findings of this research would be valuable for professional development planning, educational training, and especially the creation and usage of appropriate assessment methods wherein teachers can use to transcend the evolving facet of education.
Abuse of Authority Corruption Under the Government Administration Act
Authors:   Faculty of Law, Universitas Pembangunan Nasional Veteran Jakarta
Published: July 2022

Based on the Law Number 30 of 2014 concerning Government Administration, and the Supreme Court regulation have extended the absolute competence of the Administrative Court to examine elements of abuse of authority committed by state officials in carrying out their positions. However, this authority is not the only option given by law in Indonesia, which in addition there is also the authority of the general court to resolve the topic of abuse of authority that causes harm to the country. therefore, there is still ambiguity and overlap in laws related to abuse of authority which causes losses to state finances which ultimately has an impact on legal certainty and justice for related parties. This type of thesis research used normative juridical research that is descriptive. The Data used to answer the problems in this study were secondary data and primary data derived from library research. The results of the study found that the District Administrative Court was authorized to decide related elements of abuse of authority committed by the agency and/or government officials. The analysis of the state administration Case Number: 2/P/PW/2017/PTUN.JBI. not compatible with Perma No. 4 of 2015 because it did not meet the requirements, the new court is authorized to accept, examine, and decide the assessment of the application, after the results of the supervision of the government Internal Audit apparatus (APIP) and the court is authorized to accept, examine, and decide the assessment of the application for assessment of whether or not there was abuse of authority in the decisions and/or actions of government officials before the criminal process. The conclusion obtained was the analysis of the consideration of judges and the decision of the PTUN Jambi was wrong and not in accordance with what was mandated in Regulation No. 4 of 2015 (Perma No. 4 of 2015) on guidelines in the assessment of judicial elements of abuse of authority. It is recommended to the government to harmonize laws and regulations related to abuse of authority both in terms of criminal and administrative aspects of the government in order to achieve regulatory harmony.
New inland records of the bull shark Carcharhinus leucas from Sumatra, Indonesia
Authors: Gausmann Peter , Hasan Veryl
Published: July 2022

Six new records of the bull shark Carcharhinus leucas from five different river basins of Sumatra, Indonesia, were reported as a result of captures by artisanal and recreational fishers, including records from rivers of northern and western Sumatra for the first time. These findings may higlight the importance of Sumatran river basins for the reproduction of this threatened species in Indonesian waters. Inland records of C. leucas in Southeast Asia and in particular Indonesia are scarce but important for nature conservation purposes and sustainable future fishery management.
Competencias investigativas en el seminario final de la licenciatura en educación. Estudio exploratorio
Authors:   Universidad Siglo 21, Londero Laura Beatríz , Soria Sandra del Valle ,   Universidad Siglo 21
Published: July 2022

Las competencias investigativas de los estudiantes que cursan Seminario de Trabajo Final en la Licenciatura en Educación surgen como resultado de un estudio exploratorio cuyo propósito fue conocer el uso de las herramientas didácticas y recursos tecnológicos que utilizan los estudiantes al llegar a esta instancia. Éstas forman parte del desarrollo de las competencias investigativas que se necesitan para alcanzar con éxito la elaboración de un producto al que se denomina Plan de Intervención o Manuscrito Científico. Las evidencias aquí presentadas son el resultado parcial de una investigación de enfoque mixto. En el capítulo de referencia se han recuperado aportes teóricos conceptuales acerca de las competencias investigativas que surgen de trabajos de autores interesados y especializados en el desarrollo de las mismas. El sentido que éstos le otorgan a estas competencias en la formación docente contribuye a fortalecer los planteos realizados a partir del análisis de los datos arrojados por la encuesta y la entrevista. Para concluir, se ha destacado la relevancia que cobra el trabajo empírico, toda vez que ofrece certeza de las limitaciones que presentan los estudiantes en relación a la escritura académica, su sintaxis, redacción y coherencia en la presentación de sus trabajos final de grado.
Identificación de la teoría socioeconómica costos- desempeños ocultos en una MIPYME del sector comercial
Authors:   Universidad Autónoma del Estado de Hidalgo, Franco López Vianey , Salazar Hernández Blanca Cecilia ,   Universidad Autónoma del Estado de Hidalgo, Villegas González Eleazar ,   Universidad Autónoma del Estado de Hidalgo
Published: July 2022

Los costos-desempeños ocultos como su nombre lo indica son costos los cuales son difíciles de detectar por medio la contabilidad usual, legando a ser la principal afectación de los resultados financieros, dichos costos o vicios llegan a evitar el crecimiento o en su defecto son precursores de la quiebra en las organizaciones, utilizando el modelo socioeconómico se ha detectado los disfuncionamientos inmersos en las compañías dedicadas a diversos sectores, sin embargo, el sector comercial es el que presenta menos investigaciones, por lo que se desarrolla la presente estudio con el objetivo de estudiar la teoría socioeconómica costos-desempeños ocultos en una MiPyme de este sector, a través de una metodología de enfoque cualimétrico, apoyándose de la observación directa, teniendo como resultado preliminar que la empresa “El Dragon” presenta disfuncionamientos en las siguientes dimensiones: condiciones de trabajo, organización del trabajo, 3c, implementación de estrategia, gestión de tiempo y formación integrada, por lo que se ve en la necesidad de continuar con los siguientes pasos para cuantificar el impacto económico que presentan y diseñar el plan de acción adecuado.
Gnoseologìa de la flexibilización laboral interna
Authors:   Alianza de Investigadores Internacionales S.A.S. ALININ, Nieves Álvarez Maybeth Josefina , Chirinos Araque Yamarú del Valle ,   Universidad Católica Luis Amigó, Godínez López Roberto ,   Universidad de Guanajuato, Rojas Nieves Dorkys Coromoto ,   Alianza de Investigadores Internacionales S.A.S. ALININ
Published: July 2022

Hoy en día el mundo del trabajo ha venido presentando cambios transcendentales, constituidos por procesos de adaptación y ajustes en el ámbito laboral lo que ha generado la adopción de nuevas formas de organización del trabajo, así como también nuevas formas para gestionar el talento humano, lo que ha favorecido el surgimiento y el crecimiento del proceso flexibilizador en estos aspectos. Es por ello que la presente investigación tiene como objetivo analizar la flexibilización laboral interna, desde sus dimensione e indicadores, desarrollada bajo el tipo de investigación documental, de alcance descriptivo, utilizando fuentes secundarias para la recolección de la información. Haciendo inferencia sobre los postulados de autores como Ganga (2014), Arancibia (2011), Rodríguez (2009); González (2011). Una vez realizado un análisis comparativo en las definiciones planteadas por los autores mencionados y a través de una sinopsis se puede concluir que existen dos tipos de dimensiones que conforman la flexibilización laboral interna, una de tipo cuantitativo numérico, referida específicamente a la disposición variable de la empresa en cuanto a jornadas laborales y niveles de producción y la otra de tipo cualitativo funcional, orientada a la organización del trabajo y de los procesos, cada una compuesta por indicadores que la definen ampliamente.
Despliegue de sistemas de monitoreo sustentados en telecomunicaciones
Authors:   UCompensar Fundación Universitaria Compensar, Molero Suarez Luis Guillermo , Roa Ruiz María Camila ,   UCompensar Fundación Universitaria Compensar, Araque Moreno Miguel Andrés ,   UCompensar Fundación Universitaria Compensar
Published: July 2022

La investigación tuvo como propósito analizar el despliegue de sistemas de monitoreo sustentados en las telecomunicaciones. El estudio se ubicó en el paradigma cualitativo a través de un estudio documental, con diseño bibliográfico descriptivo. Para lograr dicho propósito en la investigación, las categorías analizadas fueron: Sistemas de monitoreo como método para el control de patologías, Telecomunicaciones que sustentan los sistemas de monitoreo para construir un análisis sobre la base de las teorías planteadas por Rosas y Sánchez, (2006), Adochiei et al., (2011), Anttalainen et al., (2016), Blasetti et al., (2000), Bozomitu et al.(2014),Viloría et al., (2014), Cisco Systems, Inc., (2003), Bidgoli, (2008), entre. Dentro de los hallazgos, se presentó una serie de investigaciones de tipo científico-tecnológica sobre el uso de los sistemas de monitoreo sustentados en las telecomunicaciones como herramienta óptima en el control de patologías clínicas y en consecuencia brindar un tratamiento efectivo que ofrezca al paciente mejora en su calidad de vida. Las conclusiones de la investigación ratifican el uso de sistemas de monitoreo sustentado en las telecomunicaciones como instrumento de control que proporciona eficiencia, eficacia, efectividad en el control y tratamiento de diferentes patologías clínicas.
Granja agroturística interpretativa de saberes agrícolas tradicionales con enfoque educativo sustentable
Authors:   Universidad Técnica del Norte, Trujillo Carmen Amelia , Lomas Tapia Kennedy Rolando ,   Universidad Técnica del Norte, Chiliquinga Cevallos Luis Adrián ,   Universidad Técnica del Norte, Chiliquinga Jaramillo Luis Adrian ,   Universidad Técnica del Norte
Published: July 2022

El presente capítulo emerge de un proyecto de investigación interno de la Universidad Técnica del Norte, no financiado, denominado “granjas agrícolas interpretativas en la comunidad de Peguche, Otavalo”, y tuvo como propósito diseñar un producto agroturístico interpretativo para el aprovechamiento sustentable del patrimonio agrícola andino en comunidades indígenas otavaleñas. Es una investigación cuantitativa, descriptiva y de campo. Se aplicaron matrices de observación para analizar y seleccionar la chakra emblemática interpretativa ambiental con la selección y caracterización de potenciales interpretativos en las chacras andinas que requirió de criterios y rasgos señalados por autores de la interpretación; para el diseño del sendero se utilizó la guía metodológica de interpretación ambiental. Los resultados fueron una chacra emblemática interpretativa con 10 potenciales de diversidad agrícola etnobotánica, patrimonial y cultural caracterizados e interpretados en un sendero interpretativo semicircular, autoguiado, denominado Mil formas, mil colores y mil sabores, con nueve (9) paradas interpretativas en atractivos paneles. El agroturismo es una alternativa para optimizar recursos y capacidades locales en comunidades con potenciales agrícolas y saberes tradicionales.