bluuebunny/crossref_metadata_2025 huggingface dataset:
Crystallization of Binary Alloys and Non-Equilibrium Phase Transitions
Authors: Radkevich E. V. , Vasil’eva O. A. , Sidorov M. I.
Published: December 2019

A model was constructed for the reconstruction of the initial stage of crystallization of binary alloys as a nonequilibrium phase transition, the mechanism of which is diffusion stratification. Numerical experiments were performed. Self-excitation of a homogeneous state by the edge control melt cooling condition.
Effect of standing waves on the local strength of modeled ice field
Authors: Epifanov V. P. , Sazonov K. E
Published: December 2019

Two scenarios of the influence of standing waves on the strength properties of ice lying on the surface of the liquid are considered: in the process of freezing the ice field and as a result of instability, which is caused by compression on the pool walls due to the expansion of water during freezing. The obtained experimental hardness profiles of the ice field indicate the formation of periodic structures characteristic of the wave process. It is shown that in both cases the standing waves arising in the basin change the strength characteristics of the ice cover.
The precession of Mercury’s orbit
Authors: Amel’kin N. I.
Published: December 2019

Within the framework of classical mechanics the influence of the planets in the solar system to the precession of the orbit of Mercury is investigated. It is shown that the average offset of the perihelion of mercurys orbit computed within the flat limited tasks is 556,5 angular seconds per century and coincides with the observation data with relative accuracy of 2,5%. Incomplete overlap between the computed average offset and observations can be explained by the presence in observations offset oscillatory components with a total amplitude up to 20 angular seconds and periods from several years to several decades.
Precambrian diamond crystals from the Siberian craton
Authors: Afanasiev V. P. , Pokhilenko N. P. , Egorova E. O. , Leendenblot E. S.
Published: December 2019

Analysis of diamond grains from placers in the northeastern Siberian craton shows that some diamond varieties (round dodecahedra, varieties II and V-VII in the classification of Orlov) may originate from Precambrian sources. The Precambrian diamonds have different sedimentation histories. Namely, diamonds of varieties V-VII are most strongly rounded though being the most resistant to wear. Therefore, they should have the longest history of dispersal and transport, and thus should be derived from the oldest primary deposits.
Dissolution of pyrochlore and microlite in alkaline, sub-aluminous and high-aluminous granitoid melts
Authors: Chevychelov, V. Yu. , Virus A. A. , Shapovalov Yu. B.
Published: December 2019

The represented experimental data on the Ta and Nb contents in acidic magmatic melts of different compositions, when dissolving pyrochlore and microlite at T = 650850 C and P = 100400 MPa, make it possible to obtain quantitative characteristics to create physico-chemical models of the genesis of TaNb deposits. At pyrochlore dissolution in granitoid melts at P = 100 MPa, the highest Nb content (0,71,9 wt.%) is obtained in alkaline melts, it decreases to 0,060,38 wt.% in sub-aluminous melts, and then slightly increases to 0,110,41 wt.% in high-alumina melts. An increase in temperature increases the dissolution of pyrochlore, and an increase in pressure decreases its. In high-alumina granite melts the pyrochlore is unstable. At the microlite dissolves with the increase in the alumina-rich melt, the Nb/Ta ratio in the melt increases approximately doubles.
The CoOccurence of Hyoplagus and Lepus (Leporidae, Lagomorpha) in the early pleistocene of Crimea
Authors: Lopatin A. V.
Published: December 2019

New fossils of Leporidae from the Lower Pleistocene deposits of the Taurida Cave in the central Crimea (Belogorsk district, Zuya village) are referred to Hypolagus brachygnathus (Kormos, 1930) and Lepus sp. Cooccurrence of Hypolagus and Lepus in the Early Pleistocene of Crimea is significant in terms of the question of the first appearance of Lepus in Europe, as well as the hypothesis of the competition with hares as one of the possible causes of extinction of Hypolagus.
TATA KELOLA ANGGARAN DESA YANG BERSUMBER APBN DALAM RANGKA MEWUJUDKAN PEMBANGUNAN MASYARAKAT PINGGIRAN BERBASIS PEMERATAAN PEMBANGUNAN PEDESAAN DALAM PERSPEKTIF NAWA CITA (STUDI KASUS DI WILAYAH CIAYUMAJAKUNING)
Authors: Sugianto Sugianto , Leliya Leliya , Ubaidillah Ubaidillah
Published: December 2019

Rural development in an integral part of regional development and national development as an effort to improve the quality of community’s life. The implementation of this rural development program is very important in the context of national development because rural areas occupy the largest portion in the entire country. The purpose of this study was to find out the village budget management sourced from the state budget in order to realize rural community development based on rural development in the perspective of Nawa Cita and the role of the village government in running the Nawa Cita program on peripheral community development on village government budget management based on people’s interest in order to realize equitable development.

This study used a qualitative approach in order to investigate and understand the phenomena such as what happens, why it happens, and how it happens while understanding a social situation, events, and interaction roles. Data collection was carried out by conducting interview with the Head of BPMPD Department of Cirebon Regency, the Head of BPMPD Department of Kuningan Regency, the Head of BPMPD Department of Majalengka Regency and the Head of BPMPD Department of Indramayu Regency and all village heads in Cirebon, Indramayu, Majalengka, and Kuningan Regions. As well as the data were obtained from the documents in regency, disctrict, and village.

The result of this study showed that village as the frontline of the development has strategic role in the success of the Nawa Cita Program. The village budget management is based on the principle of transparency, accountability, participatory, efficient, effective, orderly and budgetary discipline by paying attention to the justice principles, propriety and benefits for the village community. The implementation of activities in the APBD is carried out by the implementing team consisting of the elements from village apparatus and community institutions and supervised by the BPD, at the end of each fiscal year the Village Head has the obligation to submit a village government management report (LPPD) to the regional head through sub-district head and submit information to the LPPD to the BPD.
PERLINDUNGAN HAK ATAS KEKAYAAN INTELEKTUAL BATIK TRADISIONAL PAOMAN DALAM MENINGKATKAN EKONOMI MASYARAKAT INDRAMAYU
Authors: Suratno Ujang
Published: December 2019

Indonesia has some varieties of ethnic groups that are rich in diversity of intellectual property, there are so many products produced by society. The society creations especially created by the community are assorted, one of them is Paoman Batik. Thre are two kinds of Paoman Batik, those are contemporary and traditional, which is distinguished by its motives, processes, creators. The Paoman Traditional Batik is well-known to the public than contemporary. This research has supported the creators or copyright holders to get higher benefits, both the benefits of moral and economic rights. The main problem is, first, is the current intellectual property rights regime able to provide the foundation for the protection of Paoman Traditional Batik? Second, is the UNESCO's determination that stated if batik is a world heritage, non-object from Indonesia, can be used as the foundation to charge the economic rights of Paoman Traditional Batik? Third, is it possible for Traditional Batik, including Paoman Traditional Batik, to be carried out through other regimes, in addition to the intellectual property regime? Fourth, how is the effect of Paoman Traditional Batik Registered at the Directorate General of Intellectual Property of Indonesia on the Progress of Indramayu society?

The research method used is descriptive specification, by using juridical empirical approach, which focus on secondary research consisting of legal materials, both primary, secondary and tertiary. However it is supported by primary data generated from field research through in-depth interview and survey techniques. The analysis used is descriptive analysis.

The results of the study show that intellectual property rights that is copyright cannot be made as the foundation of protection against the creation of society that have traditional and communal motives, including the Paoman Tradsional Batik. The establishment of Batik by UNESCO as a non-object world heritage from Indonesia has increased the moral rights of Indonesia, but it also cannot be established as the foundation for restoring economic rights when there is a misappropriation. Another alternative to intellectual property is through the Sui Generis regime, which specifically addresses the protection of community rights, including intellectual property rights.
PEMBAYARAN UANG PENGGANTI DAN APLIKASINYA DALAM TINDAK PIDANA KORUPSI
Authors: Indra Ariska Dudung
Published: December 2019

Currently, the issue which is becoming a very big problem is the Corruption Crime. Both corruption carried out openly or clandestinely are all crimes that are very detrimental to society and the State. State losses in corruption are one of the elements that must be proven by the Public Prosecutor, especially for the proven state losses. Corruption Crime also recognizes the efforts of the perpetrators to return the corrupt money to the state. The case of returning the results of corruption to the state as a remedy for the Defendant in freeing himself from the snare of corruption charges. Payment of this substitute money should not exceed the amount of money which was corrupted, so it is expected that the lost state finances can be returned. However, it is not easy to get a replacement payment, since the problems that will be found in practice are very diverse in their problems, even if the money from corruption needs to be found, it must be traced in advance.
KEWENANGAN PELAKSANA TUGAS MENTERI DALAM MENGAMBIL KEPUTUSAN DAN TINDAKAN YANG BERSIFAT STRATEGIS BERDASARKAN UNDANG - UNDANG NOMOR 30 TAHUN 2014 TENTANG ADMINISTRASI PEMERINTAHAN
Authors: Egi Dwitama Sigit
Published: December 2019

One form of decree that is included in the scope of state administration is a Ministerial Decree, which is a decision determined and issued by a minister who is always concrete-individual in the form of administrative stipulations (beschikking). However, not all departments and/or government officials such as the Minister have the authority to form these decisions, because in forming decisions can be seen from the status of government officials as an example of the Ad Interim Minister who does not have the authority to issue strategic decisions. But different problems arise when there is Ad Interim of Energy and Mineral Resources Minister Luhut Binsar Pandjaitan issued Decree Number 6752 K / 70 / MEM / 2016 concerning Dissolution of Ad Hoc Organizational Units in the Ministry of Energy and Mineral Resources, which basically was a strategic decision.

This study is a legal research using a normative juridical approach and descriptive analytical research specifications. The data used in this study are secondary data consisting of primary, secondary and tertiary legal materials. Data obtained through library studies and field research in the form of legislation, books, journals, and electronic media.

The results of this study consist of 2 (two) analyzes, namely First, the position of the Acting Decree of the Minister of ESDM does not have legal validity because there is a disability when viewed from the aspect of authority, formation process, and the purpose of its establishment with legislation and AUPB and Second, towards legal validity which is not possessed by the Minister's decree executor, the decree becomes invalid and a mechanism is needed to cancel the decree.
LOGICO-HYPOTHETICO-VERIFICATIF SEBAGAI METODA ILMIAH DALAM MENCARI ILMU PENGETAHUAN YANG BENAR
Authors: Rohendi Acep
Published: December 2019

Man's journey in finding the truth to overcome problems in his life, discussing various theories / flows in his time and continually developing complementary. Correlation of truth flow that emphasizes truth is in accordance with what is expected by humans or human experience. Arguments that are not in accordance with facts are not truth. Something is considered to be something that is in accordance with the facts (empirical). Contrary to this theory is the theory of Consistency, which confirms something that supports the truth that was previously questioned. The scientific method as a path of truth is used to get knowledge using Correspondence theory and Consistency theory. Combined theories of correspondence and consistency theory produce the term "Logico-hypothetico-verificatif" with all its advantages and disadvantages.
The Topological Connectivity of the Independence Complex of Circular-Arc Graphs
Authors: ABD ALGANİ Yousef
Published: December 2019

Let us denoted the topological connectivity of a simplicial complex $C$ plus 2 by $\eta(C)$. Let $\psi$ be a function from class of graphs to the set of positive integers together with $\infty$. Suppose $\psi$ satisfies the following properties: \newline $\psi{(K_{0})}$=0. \newline For every graph G there exists an edge $e=(x,y)$ of $G$ such that $$\psi{(G-e)}\geq{\psi{(G)}}$$ (where $G-e$ is obtained from $G$ by the removal of the edge $e$), and $$\psi{(G-N(\lbrace x,y \rbrace))}\geq{\psi{(G)}}-1$$  then $$\eta{(\mathcal{I}{(G)})}\geq\psi{(G)}$$ (where $(G-N(\lbrace x,y \rbrace))$ is obtained from $G$ by the removal of  all neighbors of $x$ and $y$ (including, of course, $x$ and $y$ themselves). Let us denoted the maximal function satisfying the conditions above by $\psi_0$. Berger [3] prove the following conjecture: $$\eta{(\mathcal{I}{(G)})}=\psi_{0}{(G)}$$ for trees and completements of chordal graphs. Kawamura [2]  proved conjecture, for chordal  graphs. Berger [3] proved Conjecture for trees and completements of chordal graphs. In this article I proved the following theorem: Let $G$ be a circular-arc graph $G$ if $\psi_0(G)\leq 2$ then $\eta(\mathcal{I}(G))\leq 2$. Prior the attempt to verify the previously mentioned cases, we need a few preparations which will be discussed in the introduction.
Dynamics of a Host-Parasitoid Model Related to Pennycuick Growth Form
Authors: AK GÜMÜŞ Özlem , BİLGİ Bekir Sıtkı
Published: December 2019

In this study, the dynamical results of the model by obtaining the steady states existing in the host-parasitoid model were given. Also, some results relating to steady states of the model by depending the parameter made from biological assumptions were obtained.
Solutions of a System of Two Higher-Order Difference Equations in Terms of Lucas Sequence
Authors: HALİM Yacine , KHELİFA Amira , BERKAL Massaoud
Published: December 2019

In this paper we give some theoretical explanations related to the representation for the general solution of the   system of the  higher-order rational difference equations $$ x_{n+1} = \frac{5 y_{n-k}-5}{y_{n-k}}, \qquad y_{n+1} = \frac{5 x_{n-k}-5}{x_{n-k}} ,\qquad n, k\in \mathbb{N}_0, $$ where  $\mathbb{N}_{0}=\mathbb{N}\cup \left\{0\right\}$,  and the initial conditions $x_{-k}$, $x_{-k+1},\ldots$, $x_{0}$, $y_{-k}$, $y_{-k+1},\ldots$, $y_{0}$ are non zero real numbers such that their solutions are associated to Lucas numbers. We also study the  stability character and asymptotic behavior of this system.
Revisiting Criteria for Psychosis in Alzheimer’s Disease and Related Dementias: Toward Better Phenotypic Classification and Biomarker Research
Authors: Fischer Corinne E. , Ismail Zahinoor , Youakim James M. , Creese Byron , Kumar Sanjeev , Nuñez Nicolas , Ryan Darby R. , Di Vita Antonella , D’Antonio Fabrizia , de Lena Carlo , McGeown William J. , Ramit Ravona , Rasmussen Jill , Bell Joanne , Wang Huali , Bruneau Marie-Andrée , Panegyres Peter K. , Lanctôt Krista L. , Agüera-Ortiz Luis , Lyketsos Constantine , Cummings Jeffrey , Jeste Dilip V. , Sano Mary , Devanand D.P. , Sweet Robert A. , Ballard Clive
Published: December 2019

Background:

Psychotic symptoms are common in Alzheimer’s disease (AD) and related neurodegenerative disorders and are associated with more rapid disease progression and increased mortality. It is unclear to what degree existing criteria are utilized in clinical research and practice.

Objective:

To establish research criteria for the diagnosis of psychosis in AD.

Methods:

The International Society to Advance Alzheimer’s Research and Treatment (ISTAART) Neuropsychiatric Symptoms (NPS) Professional Interest Area (PIA) psychosis subgroup reviewed existing criteria for psychosis in AD and related dementias. Through a series of in person and on-line meetings, a priority checklist was devised to capture features necessary for current research and clinical needs. PubMed, Medline and other relevant databases were searched for relevant criteria.

Results:

Consensus identified three sets of criteria suitable for review including those of Jeste and Finkel, Lyketsos, and the Diagnostic and Statistical Manual for Mental Disorders, 5th edition. It was concluded that existing criteria could be augmented by including a more specific differentiation between delusions and hallucinations, address overlap with related conditions (agitation in particular), adding the possibility of symptoms emerging in the preclinical and prodromal phases, and building on developing research in disease biomarkers.

Conclusion:

We propose criteria, developed to improve phenotypic classification of psychosis in AD, and advance the research agenda in the field to improve epidemiological, biomarker, and genetics research in the field. These criteria serve as a complement to the International Psychogeriatric Association criteria for psychosis in neurocognitive disorders.
An Exploratory Phase IIa Study of the PPAR delta/gamma Agonist T3D-959 Assessing Metabolic and Cognitive Function in Subjects with Mild to Moderate Alzheimer’s Disease
Authors: Chamberlain Stanley , Gabriel Hoda , Strittmatter Warren , Didsbury John
Published: December 2019

Background:

T3D-959 is a chemically unique, brain penetrant, dual PPAR delta/gamma agonist with 15-fold higher PPAR delta selectivity. Ubiquitous brain expression of PPAR delta, its critical role in regulating glucose and lipid metabolism, and the Alzheimer’s disease (AD)-like phenotype of PPAR delta null mice motivated this study.

Objective:

To determine safety and tolerability of multiple doses of T3D-959 in subjects with mild to moderate AD, examine systemic and central drug pharmacology and in an exploratory manner, perform cognitive assessments.

Methods:

Thirty-four subjects with mild-to-moderate AD were orally administered 3, 10, 30, or 90 mg of T3D-959 daily for 14 days. There was no inclusion of a placebo arm. Safety and tolerability were monitored. Systemic drug pharmacology was examined via plasma metabolomics LC-MS-MS analysis, cerebral drug pharmacology via FDG-PET measures of changes in Relative CMRgl (R CMRgl, AD-effected regions relative to brain reference regions), and cognitive function assessed before and after drug treatment and again one week after completion of drug treatment, by ADAS-cog11 and the Digit Symbol Substitution Test (DSST).

Results:

T3D-959 was in general safe and well tolerated. Single point pharmacokinetics at the Tmax showed dose dependent exposure. Plasma metabolome profile changes showed dose-dependent systemic effects on lipid metabolism and metabolism related to insulin sensitization. Relative FDG-PET imaging demonstrated dose-dependent, regional, effects of T3D-959 on R CMRgl based on the use of multiple reference regions. ADAS-cog11 and DSST cognitive assessments showed improvements with possible ApoE genotype association and pharmacodynamics related to the mechanism of drug action.

Conclusions:

Exploratory data from this Phase IIa clinical trial supports further clinical investigation of T3D-959 in a larger placebo-controlled clinical study.
Global Vascular Risk Score and CAIDE Dementia Risk Score Predict Cognitive Function in the Northern Manhattan Study
Authors: Rundek Tatjana , Gardener Hannah , Dias Saporta Anita Seixas , Loewenstein David A. , Duara Ranjan , Wright Clinton B. , Dong Chuanhui , Levin Bonnie , Elkind Mitchell S.V. , Sacco Ralph L.
Published: December 2019

Background:

Modifiable vascular risk factors (VRF) have been implicated in cognitive impairment.

Objective:

We compared the prediction of cognitive performance between the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) dementia risk score, a validated tool to estimate dementia risk using VRF, and the Northern Manhattan Study (NOMAS) global vascular risk score (GVRS), created to predict vascular events.

Methods:

The CAIDE and GVRS scores were calculated based on baseline VRF among 1,290 stroke-free participants in the prospective population-based NOMAS MRI cohort (mean age 64±8 years, 60% women; 66% Hispanic, 17% Black, 15% White; 46% completed high school). Domain-specific Z-scores were derived for episodic and semantic memory, executive function, and processing speed, and averaged to calculate global cognition.

Results:

The CAIDE score was associated with worse global cognition at initial assessment (Beta per SD = –0.347, p < 0.0001), and with greater decline over time (Beta per SD = –0.033, p = 0.02). These associations were largely due to age and education, and the association with cognitive decline was not significant after adjusting for age, sex, and education. The GVRS was inversely associated with global cognition at initial testing (Beta per SD = –0.247, p < 0.0001) and greater decline over time (Beta per SD = –0.127, p < 0.0001), which persisted after adjusting for sociodemographics. The associations for both scores with initial cognitive performance were driven by executive function and processing speed, and the GVRS was associated with decline in episodic memory and processing speed.

Conclusions:

The GVRS was a stronger predictor of cognitive decline than the CAIDE in a multi-ethnic urban cohort. The inclusion of glucose and smoking in the GVRS, which are absent in CAIDE, likely explains the better performance of the GVRS.
Clinical Association of White Matter Hyperintensities Localization in a Mexican Family with Spastic Paraparesis Carrying the PSEN1 A431E Mutation
Authors: Santos-Mandujano Rosalía A. , Ryan Natalie S. , Chávez-Gutiérrez Lucía , Sánchez-Torres Carmen , Meraz-Ríos Marco Antonio
Published: December 2019

Presenilin 1 gene ( PSEN1) mutations are the most common cause of familial Alzheimer’s disease (FAD). One of the most abundant FAD mutations, PSEN1 A431E, has been reported to be associated with spastic paraparesis in about half of its carriers, but the determining mechanisms of this phenotype are still unknown. In our study we characterized three A431E mutation carriers, one symptomatic and two asymptomatic, from a Mexican family with a history of spastic paraparesis in all of its affected members. At cognitive assessment and MRI, the symptomatic subject showed an atypical non-amnestic mild cognitive impairment with visuospatial deficits, olfactory dysfunction and significant parieto-occipital brain atrophy. Furthermore, we found several periventricular white matter hyperintensities whose progression pattern and localization correlated with their motor impairment, cognitive profile, and non-motor symptoms. Together, our data suggests that in this family the A431E mutation leads to a divergent neurological disorder in which cognitive deterioration was clinically exceeded by motor impairment and that it involves early glial and vascular pathological changes.
Uric Acid and High-Density Lipoprotein Cholesterol Are Differently Associated with Alzheimer’s Disease and Vascular Dementia
Authors: Liu Hanxiang , Reynolds Gavin P. , Wei Xianwen
Published: December 2019

Uric acid (UA) is a major contributor to naturally-occurring antioxidant activity and is thought to have protective effects against neurodegenerative processes. However, UA is also implicated as a risk factor in vascular, including cerebrovascular, disease. Its association with, and role in, dementia and its component diseases including Alzheimer’s disease (AD) and vascular dementia (VaD) remains unclear and inconsistently studied. Changes in blood lipids, particularly cholesterol measures, have also been implicated in dementias although the relationship or interactions with UA have been little studied.

We have measured plasma UA and lipids taken from 187 subjects first attending a general hospital neurology department for symptoms associated with dementia, and from a series of 79 healthy control subjects. Diagnoses of AD and VaD were made following neuroimaging; laboratory measures were compared between dementia and control groups and between AD and VaD subgroups. No overall change in UA was seen in dementia, although a substantial and highly significant reduction was found in the AD patients. Reduced values in total cholesterol, HDL, and LDL were found in dementia, independent of statin treatment. Further investigation found a significant reduction of HDL only in the VaD group, while total cholesterol was significantly reduced in both AD and VaD subjects.

These findings indicate that in our Chinese sample, UA deficits are specifically associated with AD, while deficits in HDL cholesterol found in dementia tend to be greater in VaD.
Assessing and addressing footwear needs in Parkinson’s disease—design thinking in neurology
Authors: Sayadi Jamasb , Sayadi Lohrasb Ross , Fijany Arman , Chopan Mustafa , Hermanowicz Neal
Published: December 2019

BACKGROUND: Parkinson’s disease (PD) is a neurodegenerative movement disorder that results in a variety of motor deficits such as unsteady gait, bradykinesia, resting tremor, and rigidity. OBJECTIVE: The objective of this study was to quantify and assess the challenges and preferences Parkinson’s disease patients have regarding footwear. METHODS: A 13-question survey was designed to assess footwear challenges and preferences among PD patients. A total of 89 PD patients, both male and female, were surveyed in the outpatient setting at UC Irvine during their appointments with the senior author. RESULTS: A majority of the PD patients in our cohort (64%) reported experiencing difficulties wearing shoes on their own. Patients who experienced difficulties wearing shoes were significantly more likely to report having been forced to make changes to their desired outfits (p = 0.0011), choosing not to wear dress shoes due to their discomfort (p = 0.0175), and preferring shoes without laces (p = 0.0 048). CONCLUSIONS: The present study is the first attempt to use a survey to quantify the challenges and preferences reported by PD patients in regard to their usage of footwear. Inspired by our findings, the study team designed a novel dress shoe prototype that may address some of the difficulties and concerns gathered through our survey.
Macrophages — a perspective target for antineoplastic immunotherapy
Authors: Karaman О.М. , Ivanchenko A.V. , Chekhun V.F.
Published: December 2019

Summary. The review discusses the data on the functional/phenotypic M1/M2 types of macrophages and their chimeric forms, the molecular mechanisms of polarization of these cells, and their role in the development of malignant tumors. Information on the prognostic value of the presence (density and location) of M1/M2 cells in tumor tissue is analyzed. Our own results evidence on the necessity of determination of the functional/phenotypic state of M1/M2 macrophages from different biological niches in the dynamics of tumor growth, in particular in terms of NO level and arginase activity.
Morphological characteristics and expression of adhesion markers in cells of low differentiated endometrial carcinoma
Authors: Buchynska L.G. , Naleskina L.А. , Nesina I.P.
Published: December 2019

Summary. The aim of the study was to evaluate the morphological features of endometrioid carcinoma of the endometrium (ECE) of low differentiation grade with different invasive potential and to characterize their molecular phenotype by the expression of a number of adhesion markers. Materials and Methods: We have studied the samples of operation material of 37 patients with ECE of low differentiation grade with deep invasion (> ½ myometrium), n = 26, and with invasion < ½ myometrium, n = 11, with the use of morphological and immunohistochemical methods, and flow cytometry. Results: In the morphological study of tumors with deep invasion in the myometrium, we have detected pronounced structural heterogeneity, which became the basis for the discretion of two groups of tumors with different characteristics of morphological phenotypes. In the majority of cases, solid layers and glandular-like structures are detected, and the similarity of the tumor epithelium with the elements of the endometrium is completely lost. In such tumors high expression of adhesion molecules – E-cadherin, CD44, CD24, and β-catenin and low expression of the marker of mesenchymal tissues — vimentin were determined. Other tumors were characterized by morphological features of the epithelial-mesenchymal transition (EMT), with the decrease of the expression of E-cadherin, β-catenin, CD24, CD44, and a significant increase in vimentin expression in comparison with these indices in tumors without signs of EMT. In ECEs that invade < ½ myometrium, the morphological indices of malignancy were less pronounced, which was associated by the changes in the expression of the molecular markers. Conclusion: This comprehensive study has established associations between the morphological heterogeneity of ECE and the expression of adhesion markers and vimentin, which is important for understanding the mechanisms of tumor cell migration.
试分析蔬菜种植中虫害发生特点与防治技术
Authors: 田 维举
Published: December 2019

随着经济的发展人民生活的水平日益提高,对生活质量方面的考量变得尤为谨慎,尤其是对于食品类的监督,因此农业种植的要求越来越高,农业结构的变化也逐渐向着工厂化靠拢,蔬菜种植在农业种植中比重增长,蔬菜种植带来的经济效益也愈发凸显,种植技术方面的革新换代也让种植实现规模化、企业化,随之而来的针对病虫害特点的防治工作也逐渐被推向了蔬菜种植的中心。
吉水县水禽产业发展现状与思路
Authors: 周 琴 , 李 美珠 , 高 仟仟 , 刘 爱萍
Published: December 2019

随着社会经济的快速发展,吉水县水禽产业也取得了巨大进步。从经营规模来看,吉水县水禽产业已从传统的农村家庭副业发展为农村经济的重要产业之一。在水禽养殖体系中,鹅鸭占据了较大的生产比重。尽管吉水县在省内发展了一批较有影响的生产龙头企业,但是与其他县市相比,仍然存在着些许问题。为此,本文对吉水县水禽产业发展现状与思路进行了分析。望能够给相关工作者带来一定的启示意义。
无公害蔬菜病虫害防治策略探讨
Authors: 李 翊权
Published: December 2019

病虫害是影响我国无公害蔬菜种植领域发展的重要因素,严重降低了蔬菜种植的质量和产量,给广大菜农带来极大的经济损失。传统蔬菜种植模式由于大量使用化学农药,在蔬菜中残留大量有毒物质,给人们身体健康带来极大危害。本文就无公害蔬菜病虫害防治策略进行全面探讨和研究,希望推动我国无公害蔬菜种植领域的长远稳定发展。
论短时临近天气预报在农业气象服务中的应用
Authors: 毕 圣欣
Published: December 2019

短时临近天气预报可以为农户提供准确可靠的自然灾害预警信息,从而保障我国农业的健康发展。如今我国恶劣天气的数量和类型明显增多,传统的气象预报技术已无法满足我国现阶段农业发展的要求。为减轻极端恶劣天气对农业生产的负面影响,可在农业气象服务中应用短时临近天气预报系统,提前采取灾害预防措施。
畜牧兽医技术推广过程中存在的问题及解决方法
Authors: 颜 丙丽
Published: December 2019

畜牧兽医技术若想得到进一步推广,就需要结合市场发展体制,扩大养殖规模,加强动物防疫管理,且根据畜牧兽医技术中存在的问题制定合理的解决措施。本文就对畜牧兽医技术推广中存在的问题及解决方法进行阐述,以供参考。
乡村文化振兴实现路径探微
Authors: 邢 宇宙
Published: December 2019

“三农”问题历来是关系国民生计的根本性问题,在我们党实施乡村振兴战略背景下,乡村文化振兴是其重要内容,乡村建设不仅要“塑形”、“塑骨”,也要塑魂。因此,要厘清乡村文化振兴的重要意义,审视当下乡村文明建设存在的问题,并从乡村文化建设与服务机制的完善与创新、文化团体的孵化与培育、文化市场体系的健全与发展等方面探索乡村文化振兴的路径选择。
增施有机肥对水稻发育及产量的影响浅析
Authors: 王 帅 , 袁 显琳
Published: December 2019

本文将参照实际案例,对水稻栽植中增施有机肥所带来的影响及具体情况进行分析,以期有效促进水稻的生长发育,提高水稻种植的质量和产量。
寒地水稻种植及病虫害防治技术分析
Authors: 杨 利勇
Published: December 2019

水稻是一种常见的农作物,面对人口不断增长的粮食需求,水稻种植面积逐步扩大。尤其是寒地水稻种植力度不断提升,引进先进的种植技术和设备,促使粮食产量和品质大幅度提升。但是,寒地水稻种植期间,不可避免的受到病虫害问题影响,如果未能得到及时有效防治,水稻产量大幅度下降,并且会带来严重的经济损失。本文就寒地水稻种植进行分析,选择合适的病虫害防治技术,促进寒地水稻种植高产。
关于有机水稻病虫害防控方法的分析
Authors: 袁 显琳 , 王 帅
Published: December 2019

有机水稻是指不使用农药、化肥等药品,无任何有害物质的绿色水稻,有机水稻虽然无害无污染,但在种植的过程中也存在着严重的病虫害问题,而且病虫害防治难度较大,因此研究有机水稻病虫害防控方法具有十分积极的现实意义。
浅谈园林绿化养护技术的要点及养护管理的措施
Authors: 杨 海军
Published: December 2019

美化项目不是千载难逢的项目。园林绿化工程完成后,要注意维护技术的应用和维护管理,以确保园林绿化工程的功能。本文主要从园林绿化维护概述,常见园林绿化维护技术,园林绿化维护管理现状,园林绿化维护管理措施等方面论述园林绿化维护技术的重点和维护管理措施。
浅谈城市园林绿化景观施工与养护措施解析
Authors: 马 保花
Published: December 2019

城市园林景观是城市建设过程中的一个重要内容,在施工中有许多注意事项,关系到园林的美感、成本以及安全；而施工后的养护也十分重要,否则前功尽弃。本文就城市园林景观的施工和绿化养护展开阐述。
新时期绿色农业的种植技术推广
Authors: 王 东春
Published: December 2019

现阶段,我国的经济水平不断提高,大众的健康与农产品种植安全性逐渐受到社会各界的重视。因此,绿色农业重种植技术的应用与推广,不仅能够保证农产品的安全与质量,还能创造出更高的农业经济效益。本文从新时期绿色农业的种植技术推广的重要作用展开分析,并以此为依据,提出引入先进的种植技术、搭建绿色种植基地、拓宽销售渠道、搭建健全的电子商务平台等几个方面的措施,希望能够推动我国绿色农业的稳定发展。
Dificultades en el Aprendizaje de la Función Definida por Tramos: una mirada desde el enfoque instrumental de Pierre Rabardel
Authors: Chumpitaz Malpartida Luis Daniel
Published: December 2019

Luego del diseño y validación de una secuencia de aprendizaje, se llevó a cabo una experiencia de aprendizaje con estudiantes de las carreras de Ingeniería en la Universidad San Ignacio de Loyola. Para ello, los estudiantes identificaron elementos como dominio, rango e intervalos de monotonía; representaron la gráfica en un plano cartesiano; determinaron la regla de correspondencia, y realizaron transformaciones a las gráficas de las funciones definidas por tramos presentadas en las actividades de esta secuencia. Se realizó un estudio de las dificultades en el aprendizaje de la Función Definida por Tramos, debido a que es válido afirmar que, si existe la posibilidad de reducir dificultades, esto podría, a su vez, minimizar las dificultades en el aprendizaje de nuevos conocimientos del Cálculo, como los conceptos en la teoría de límites y continuidad, y en particular, en funciones cuyas gráficas no pueden ser realizadas con un solo trazo. Para identificar estas dificultades en las acciones de los estudiantes, estudiamos la Función Definida por Tramos como un objeto semiótico desde el enfoque instrumental desarrollado por Rabardel (1995). En el análisis de las interacciones de los estudiantes con la Función Definida por Tramos, se identificó que los estudiantes movilizaron esquemas de uso preexistentes que permitieron minimizar las dificultades en la secuencia de aprendizaje. También se pudo observar en las últimas actividades que algunas propiedades de este artefacto conservaron las funciones adquiridas durante su transformación a instrumento.
El hablante lírico y la conciencia del oficio de escritor en la poesía de Carlos López Degregori: una aproximación
Authors: Selenco Vega Jácome
Published: December 2019

En este artículo se analiza el papel del hablante lírico como creador en la poesía de Carlos López Degregori, así como su constante preocupación sobre el significado del oficio de la escritura. A lo largo de su obra, López Degregori construye un  yo consciente del ambiguo poder de las palabras: por un lado, ellas permiten captar la realidad en la que se vive; por otro, poseen límites y riesgos que impiden aprehender a plenitud las verdades de la existencia humana. Apoyándonos en la moderna retórica general textual, centramos nuestro análisis en el texto “Protocolo de autopsia”, uno de los más conocidos de su libro Cielo forzado (1988).
Analysis of Financial Literacy Target Groups Based on the Financial Literacy Strategy of the Russian Federation
Authors: Kuznetsov O. V. , Rodionova M. E. , Korablin Yu. A.
Published: December 2019

The relevance of this issue has been raised due to the demand for a forecast of the needs of the financial and economic segment of the market in the content and models of financial literacy in the process of achieving the national goals and strategic objectives of the development of the Russian Federation for the period up to 2024. The article presents an analysis of current issues of improving financial literacy, provides a detailed description of the main target groups on the basis of the Strategy for Improving Financial Literacy in the Russian Federation for the period 2017—2023, and presents the results pilot studies of a condition of financial literacy, financial competent behavior of the population and determining from factors on the example of one of the main target groups — school students.

The authors declare no conflict of interest.
Uniform Convergence of Cosine Series With Coefficient from New Class of General Monotone
Authors: Moch Aruman Imron
Published: December 2019

General monotone sequences class (GMS) has been introduced by Tikhonov. Then Bogdan Szal extended this class to the new class called new class of general monotone. By using non-negative sequence is called 𝛽 to controle the difference of sine series coefficient. By substituting 𝛽 of modulus of sine series coefficient, we study uniform convergence of new class of general monotone on cosine series.
Akulturasi Budaya pada Bangunan Masjid Raya Al-Ma’shun di Kota Medan (Kajian Semiotik Deskriptif)
Authors: Nursukma Suri  , Khairawati  , Nursabsyah
Published: December 2019

Masjid yang menjadi identitas kota Medan ini memang bukan sekedar bangunan antik bersejarah biasa, tetapi juga menyimpan keunikan tersendiri mulai dari gaya arsitektur, bentuk bangunan, kubah, menara, pilar utama hingga ornamen-ornamennya baik ornamen pada bangunan ataupun pada kaligrafinya yang menghiasi tiap bagian bangunan tua ini. Bangunan masjid Raya Al-Ma’shun merupakan bangunan tua dengan gaya arsitektur Eropa (Romawi, Belanda dan Spanyol), Timur Tengah, dan Asia (Moghul/India) yang dihiasi berbagai bentuk ornamen-ornamen. Setiap ornamen mempunyai tanda-tanda yang menggambarkan kehidupan keragaman budaya masa lalu hingga sekarang, kajian tanda ini di sebut juga kajian semiotik deskriptif. Tujuan penelitian ini menjelaskan makna dari tanda-tanda yang terdapat pada ornamen. Ornamen itu terdapat pada gapura utama, serambi, ruang utama, mihrab, mimbar dan menara. Bentuk  ornamen tersebuat antara lain pucuk bunga, kuntum bunga, bunga-bungaan, kelopak bunga, segi tiga, horizontal, geometris, lengkung. Makna yang terkandung dalam ornamen itu dekoratif, Lambang kekekalan, ungkapan yang sempurna untuk keadilan”. Lambang dari manusia, tentang kesadaran dan asas keselarasan.

 

The mosque which has become the identity of Medan is not merely an antique historical building, but it also has its own uniqueness such as its architecture, building shape, dome, tower, main pillars, ornaments, and the calligraphy which decorate every corner of the building. Masjid Raya Al-Ma’shun is an old mosque with the architecture of European (Rome, Holland and Spanish), Middle East, and Asian (Mughal/Indian) and decorated with many ornaments. Every ornament has signs which represent the cultural diversity from the past to present, the analysis of signs is also called descriptive semiotics. This research aimed to explain the meanings in the ornament signs. The ornaments which were analyzed were in the main gate, terrace, main room, mihrab, pulpit and tower. The ornaments shapes were flowers, flower buds, flower petals, triangle, horizontal, geometrics, and curves. The meanings represented in the signs were decorative, everlasting, and the perfect expression for justice, the symbols from human about consciousness and harmony.
Perpustakaan Berbasis Inklusi Sosial
Authors: Woro Titi Haryanti
Published: December 2019

Tujuan kebijakan transformasi perpustakaan berbasis inklusi sosial adalah untuk meningkatkan literasi informasi berbasis Teknologi Informasi dan Komunikasi, meningkatkan kualitas hidup dan kesejahteraan masyarakat  memperkuat peran dan fungsi perpustakaan, agar tidak hanya sekadar tempat penyimpanan dan peminjaman buku, tapi menjadi tempat pembelajaran sepanjang hayat dan pemberdayaan masyarakat. Perpustakaan harus  memfasilitasi masyarakat dalam mengembangkan potensinya dengan melihat keragaman budaya,  keinginan menerima perubahan, serta menawarkan kesempatan  usaha, melindungi dan melestarikan budaya dan Hak Azasi Manusia dan sesuai dengan tujuan pembangunan berkelanjutan. Transformasi perpustakaan berbasis inklusi sosial merupakan wujud perpustakaan sebagai pembelajaran sepanjang hayat. Di mana perpustakaan bukan hanya sebagai pusat sumber informasi tetapi lebih dari itu sebagai tempat mentransformasikan diri sebagai pusat sosial budaya dengan memberdayakankan dan mendemokratisasi masyarakat dan komunitas lokal,  dalam upaya peningkatan kesejahteraan masyarakat.

 

The objective of the library transformation policy based on social inclusion is to increase information literacy based on Information and Communication Technology, improve the quality of life and welfare of the community, strengthen the role and function of the library, so that it is not just a place for storing and borrowing books, but a place for lifelong learning and community empowerment. Libraries must facilitate the community in developing their potential by looking at cultural diversity, change, and offering business opportunities, protecting and preserving culture and human rights and in accordance with the goals of sustainable development. Transforming libraries based on social inclusion is a form of library as lifelong learning. Where the library is not only as a source of information but more than that as a place to transform yourself as a center for social culture by empowering and democratizing the community and local communities, in an effort to improve the welfare of the community.
Paradigms for Treating Breast Cancers Have Changed: The One-Size-Fits-All Is no Longer True
Authors: Salmon Remy
Published: December 2019

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Breast Cancer with Internal Mammary Node Metastases: A Case Presented in a Tumor Board Session and Decision Making
Authors: Meloche-Dumas Léamarie , Patocskai Erica , Boulva Kerianne , Liberman Moishe , Rami Younan
Published: December 2019

Background: There are several therapeutic options available for breast cancer treatment, now incorporating innovative targeted molecular therapies. Metastatic breast cancer is usually treated with chemotherapy and/or hormonotherapy. Surgery has not been shown to improve survival. Adjuvant radiotherapy (RT) has been proven to be effective in the treatment of locally advanced breast cancer, reducing locoregional recurrence. The optimal treatment of internal mammary lymph nodes (IMN) metastases remains controversial.

Case presentation: A 48-year-old woman was diagnosed with invasive breast cancer with ipsilateral metastases to axillary lymph nodes and a contralateral IMN metastasis. This case was presented twice during the tumor board sessions of the Surgical Oncology Service at the Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Canada.

Question: Does the internal mammary chain (IMC) dissection could be used as a treatment approach in breast cancer with IMC metastasis?

Conclusion: Internal mammary chain dissection should be discussed in tumor board sessions on a case-by-case basis. There are no strong guidelines on the management of IMN metastasis in breast cancer, but there is growing evidence that these women should be treated with curative intent.
Information System Ordering Online Restaurant Menu At Hover Cafe
Authors: Kurniawan Rano , Sutawan Ahmad , Amalia Rizky
Published: December 2019

The rapid development of technology requires every business person to upgrade his technology to more sophisticated. Many business people have upgraded their systems to be computerized and even online, one of the business people is in the culinary field. The culinary field which is meant for example is the cafe One thing that can support the quality of ordering in a cafe is the ordering process. In the hover cafe the menu ordering system is still conventional, using a menu book. This of course can be a problem because the menu book used can be damaged or lost so that it can slow down the ordering process, not to mention if the customer requests additional orders, the waiter must come to the customer's table to record additional orders again. The method used in this research is the method of data collection, the method of observation, the method of interviewing, and the method of literature study conducted to obtain accurate data. Then the data are analyzed with SWOT to find out the company's weaknesses and strengths. In describing the flow of the system using UML (Unified Modeling Language) and PHP (Hypertext Preprocessor) as a programming language with a MySQL database as a database. Therefore we need a ordering media that utilizes information technology as a medium for selecting food and beverage (E-Menu) which can provide information about order menu details to facilitate customers in making and ordering food or beverage menus.
KEBIJAKAN PEMERINTAH KOTA LANGSA TERHADAP PENGELOLAAN SAMPAH DALAM MEMENUHI PRINSIP GOOD ENVIRONMENTAL GOVERNANCE
Authors: Asiyah Nur
Published: December 2019

Pengelolaan sampah perkotaan di Indonesia masih menghadapi banyak kendala terutama dalam hal keberadaan Tempat Pembuangan Akhir (TPA) atau landfill. Hanya 60-70% sampah yang dapat terangkut dan dibuang ke TPA, sementara sisanya tersebar diberbagai tempat. Pengaturan mengenai pengelolaan sampah telah diatur dalam UU No. 18 Tahun 2008 tentang Pengelolaan Sampah dan diakomodir dalam Qanun Kota Langsa No 3 Tahun 2014 tentang pengelolaan Sampah. Apabila daerah mampu mengelola sampahnya dengan baik maka pelaksanaan terhadap prinsip Good Environmental Governance sudah dapat dikatakan terpenuhi. Penelitian ini adalah penelitian hukum doktrinal/normatif dengan pendekatan perundang-undangan. Data dikumpulkan dengan studi kepustakaan, kemudian dianalisis secara kualitatif. Kota Langsa telah mengatur prihal pengelolaan sampah dalam Qanun Kota Langsa No. 03 Tahun 2014 Tentang Pengelolaan sampah dimana kebijakan penyediaan bank sampah dan Penegakan hukum dalam pengelolaan sampah mengacu pada 3 sistem hukum yaitu struktur, substansi, dan budaya. Selain itu berkaitan dengan penegakan hukum dalam pengelolaan sampah dapat dikaji dari 2 sisi yaitu penegakan hukum secara preventif dan represif. Bank sampah dan Penegakan hukum dalam pengelolaan sampah juga menjadi sebuah perwujudan pemerintah maupun pemerintah daerah dalam menerapkan prinsip Good Environmental Governance dengan tujuan akan menumbuhkan kesadaran bagi masyarakat akan lingkungan hidup yang baik dan sehat.
Features of quality indicators of metal of boiler tubes rolled from continuously cast billets produced by Dniprostal metallurgical works LLC
Authors: Opryshko L. V. , Golovniak T. V. , Poltava I. I.
Published: December 2019

Purpose. Study of patterns of formation of structure and properties as well as the surface quality of boiler tubes in the process of tube rolling at TPA 30-102 tube rolling unit from non-worked continuously cast billets (CCB) of steel 20 produced by Dniprostal Metallurgical Works LLC. Methodology. Metallographic examination (macrostructure, microstructure, contamination by non-metallic inclusions); tensile and impact bend tests at room and elevated temperatures, determination of susceptibility to mechanical aging, long-term strength tests, visual inspection of the billet and the tube surface. Findings. Quality indicators of metal of the CCB produced by Dniprostal Metallurgical Works LLC and hot-rolled tubes produced at TPA 30-102 tube rolling unit from the CCB including service properties were investigated. Regularities of influence of quality of the initial CCB metal, technology of tube processing (hot rolling and heat treatment) on the formation of structure and properties as well as on the state of the boiler tube surface were established. Draft Technical Specifications were developed for the CCB produced by Dniprostal Metallurgical Works LLC intended for production of boiler tubes. Originality. For the first time, based on the revealed regularities of influence of the initial CCB on the formation of quality indicators of tube metal, Technical Specifications for high-duty continuously cast billets produced by Dniprostal Metallurgical Works LLC have been developed which make it possible to produce boiler tubes of high service reliability. Practical value. The research results will allow enterprises of Interpipe Ukraine JSC to produce boiler tubes of high service reliability from continuously cast billets produced by Dniprostal Metallurgical Works LLC. The use of billets of home production will reduce the cost of boiler tubes and eliminate the shortage of boiler tube billets in Ukraine. Keywords: continuously cast billet, hot rolling, elongation ratios, boiler tubes, heat treatment, macrostructure and microstructure, cast structure residues, mechanical properties, heat resistance, defects.