bluuebunny/crossref_metadata_2025 huggingface dataset:
NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner
Authors: Zhou Ying , Qian Wenxuan , Li Xiangming , Wei Wenzhi
Published: January 2023

Glioblastoma (GBM) is the most common malignant tumor of the adult central nervous system. Aberrant regulation of cell death is an important feature of GBM, and investigating the regulatory mechanisms of cell death in GBM may provide insights into development of new therapeutic strategies. We demonstrated that myrislignan has ferroptosis-promoting activity. Myrislignan is a lignan isolated from Myristica fragrans Houtt and an inhibitor of NF-κB signaling pathway. Ferroptosis is an iron-dependent form of programmed cell death characterized by the accumulation of intracellular lipid peroxidation products. Interestingly, ferroptosis was associated with other biological processes in tumor cells such as autophagy and necroptosis. Recently, the crosstalk between epithelial-mesenchymal transition (EMT) and ferroptosis has also been reported, but the mechanisms underlying the crosstalk have not been identified. Our results indicated that myrislignan suppressed growth of GBM through EMT-mediated ferroptosis in a Slug-dependent manner. Myrislignan inhibited the activation of NF-κB signaling by blocking the phosphorylation of p65 protein and induced ferroptosis through the Slug-SLC7A11 signaling pathway in GBM cells. In addition, myrislignan suppressed the progression of GBM in xenograft mouse model. Hence, our findings contribute to the understanding of EMT-induced ferroptosis and provide targets for the development of targeted therapy against GBM.
Metabolic Steal of the Myocardium by Primary Cardiac Lymphoma
Authors: Imataki Osamu , Kubo Hiroyuki , Fujita Haruyuki , Uemura Makiko
Published: January 2023

Less than 1.0% of malignant lymphomas are primary cardiac lymphoma (PCL), a rare malignant lymphoma. Due to its infrequency, the metabolic dynamics of the treatment have not been completely analyzed. A 62-year-old man who had been complaining of exertional dyspnea for a month arrived at our emergency room. He developed right cardiac failure as a result of a mass in the right atrium, according to a computed tomography (CT) scan. According to an echocardiogram, the mass was obstructing his blood flow and affecting how his heart worked. The lump was pathologically determined to be diffuse large B-cell lymphoma after he underwent urgent heart surgery. The lesion was only localized in the heart, according to a postoperative 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET)/CT scan, indicating that the disease was in clinical stage IE. An 18F-FDG-PET/CT scan showed a thickness of the right atrial wall as residual disease despite the majority of the cardiac lymphomatous mass being removed during surgery; it also showed that the usual uptake of 18F-FDG in healthy myocardium had diminished. Following chemotherapy, 18F-FDG uptake recovered in the patient’s normal myocardium of the heart in remission. In conclusion, a sort of “metabolic steal phenomenon” that may be connected to PCL is the difference in uptake between tumor-involved and healthy myocardium.
Efficacy of Intravesical Instillation Therapy with Low-Dose Tokyo-172 Bacillus Calmette-Guérin to Prevent Recurrence of Non-Muscle-Invasive Bladder Cancer and Treat Carcinoma in situ: A Multi-Institutional Retrospective Study
Authors: Tachibana Takashi , Ikeda Masaomi , Shimura Soichiro , Amano Noriyuki , Murakami Yasukiyo , Yamada Yasufumi , Koguchi Dai , Maeyama Ryota , Kawamura Mizuho , Sakata Yusuke , Hagiwara Masahiro , Matsumoto Kazumasa , Iwamura Masatsugu
Published: January 2023

Introduction: There are various doses, durations, and strains of bacillus Calmette-Guérin (BCG) intravesical instillation therapy, but optimal treatment has not yet been established. We retrospectively investigated the efficacy and safety of low-dose BCG therapy for non-muscle-invasive bladder cancer (NMIBC) and carcinoma in situ (CIS) in a multicenter study. Methods: From 1991 to 2019, 323 patients who received BCG therapy to prevent recurrence of NMIBC were analyzed as group A. Similarly, 147 patients who received BCG therapy for the treatment of CIS were analyzed as group B. Patients received low- or full-dose Tokyo-172 strain or full-dose Connaught strain, and the three strains were compared. Survival curves were estimated by the Kaplan-Meier method, and independent risk factors for intravesical recurrence were examined by multivariate logistic regression. Results: Recurrence-free survival (RFS) in group A was significantly better for the Connaught strain than the low-dose Tokyo-172 strain (p = 0.026), but not between the low- and full-dose Tokyo-172 strains (p = 0.443). RFS of group B, cancer-specific survival, and progression-free survival in both groups did not show statistically significant differences. Logistic analysis of group A showed that for intravesical recurrence, only pT1 was a significant risk factor, and there were no differences between the BCG strain and dose and no significant factors in group B. There were also no differences in the completion rate in both groups, but adverse events such as urinary frequency and feeling of residual urine were significantly lower with the low-dose Tokyo-172 strain. Conclusion: There was no difference in efficacy between the low- and full-dose Tokyo-172 strains, but to minimize adverse events, the low-dose Tokyo-172 strain may be worth considering.
A Study on the CLCN5 Gene in Iranian Patients: A Report of Novel and Recurrent Mutations
Authors: Mollataheri Ali , Mojbafan Marzieh , Hosseini Rozita , Houman Nakisa , Mousavi Mohammad , Otoukesh Hasan
Published: January 2023

Introduction: Dent’s disease is an X-linked inherited renal tubular disorder characterized by proteinuria, hypercalciuria, nephrocalcinosis, nephrolithiasis, rickets, and end-stage renal disease. Almost 60% of patients have causative mutations in the CLCN5 gene (Dent 1), and 15% of affected individuals have mutations in the OCRL1 gene (Dent 2). The aims of this study are to identify CLCN5 mutations in Iranian families with Dent’s disease and to characterize the associated clinical syndromes. Methods: We studied 14 patients from 13 unrelated Iranian families with a clinical diagnosis of Dent’s disease. Proteinuria was detected in all patients. Nephrolithiasis was found in 5 patient, and hematuria in 2 patients. Most of the affected individuals had nephrocalcinosis. PCR-sequencing for the CLCN5 gene was performed in all 14 patients. Next-generation sequencing (NGS) has also been performed in one patient who we did not find causative mutation. Results: We identified four different CLCN5 mutations including one missense mutation (c.731C>T), one nonsense mutation (c.100C>T), and two novel mutations, consisting of one frameshift mutation (c.1241_1242dupAA) and one splicing mutation (c.805-2A>G). We also identified one OCRL1 mutation, one splicing mutation (c.1466 + 1G>A), using NGS. Conclusion: This is the first report to characterize mutations in the CLCN5 gene in Iranian patients with Dent’s disease and expands the spectrum of CLCN5 mutations by reporting two novel mutations, c.1241_1242dupAA and c.805-2A>G.
The Future Role of Cytology in Cervical Cancer Screening in the Era of HPV Vaccination
Authors: Barroeta Julieta E.
Published: January 2023

Background: Up until recently, cervical cytology was the mainstay for cervical cancer screening. However, the established association between human papillomavirus (HPV) infection and cervical cancer has led to changes in preventive strategies, with cytology being replaced by the use of high-risk HPV (hrHPV) testing and primary prevention being achieved by HPV vaccination. In this context, the role of cervical cytology is shifting to secondary triage of HPV-positive women. As vaccination is leading to decreased HPV infections and significant cervical abnormalities (CIN2+), data on the impact of HPV vaccination on cervical cytology metrics, including positive predictive value (PPV) and negative predictive value (NPV), are starting to emerge. Summary: This is a review of updates in cervical cancer screening, including the use of primary HPV testing and the impact of HPV vaccination on cytology as part of cervical cancer screening. Key Messages: Cervical cancer screening and prevention are undergoing significant changes as there is widespread implementation of HPV vaccination and hrHPV testing is becoming the entry point for secondary prevention. Optimal screening approaches and intervals in this setting are currently being analyzed including the use of cytology and other ancillary techniques for triage of positive cases, as well as the effect of vaccination on the PPV and NPV of cytology in the detection of CIN2+.
Comparison of Aurolab Aqueous Drainage Implant with Ahmed Glaucoma Valve for Refractory Glaucoma: A Meta-Analysis
Authors: Hong Mingsheng , Peng Yaling , Lai Yuan , Zheng Qingqing , Hong Chaoyang
Published: January 2023

Background: Ahmed glaucoma valve (AGV) is a common surgical method for the treatment of refractory glaucoma.Aurolab aqueous drainage implant (AADI) is a novel surgical method which has been applied in clinical practice in recent years. Objective: The purpose of this study was to compare the efficacy and safety of the AADI and the AGV for the treatment of refractory glaucoma. Methods: We comprehensively searched four databases, including PubMed, Embase, Web of Science, and the Cochrane Library databases, selecting the relevant studies. The continuous variables, namely, intraocular pressure reduction (IOPR) and a reduction in antiglaucoma medication (AGMR), were pooled by the weighted mean differences (WMDs), and the dichotomous outcomes, including success rates and complications, were pooled by the odds ratio (OR). Results: A total of 825 eyes from 820 patients from six studies were included. The WMDs of the IOPR between the AADI and the AGV implant were 0.58 (95% CI: 0.07–1.09) at 3 months, 0.44 (95% CI: 0.11–0.77) at 6 months, 2.20 (95% CI: 0.63–3.77) at 12 months, and 3.24 (95% CI: 1.73–4.75) at follow-up endpoint. Significant difference was detected between the two groups at any point in time. The WMDs of the AGMR between the AADI and the AGV implant were 0.87 (95% CI: 0.61–1.13) at 6 months, 1.04 (95% CI: 0.66–1.42) at 12 months, and 0.93 (95% CI: 0.52–1.34) at the follow-up endpoint; the differences reached statistical significance at any point in time. The pooled ORs comparing the AADI with the AGV were 3.64 (95% CI: 2.44–5.45) for the complete success rate and 1.72 (95% CI: 1.24–2.39) for qualified success rate; significant difference was detected between the two groups. There were no significant differences between the AADI and the AGV implant on the rates of adverse events. Conclusions: The AADI is more effective in both its surgical success rate and reducing IOP and AGM. And the two implants may have comparable incidences of adverse events.
A Prospective Analysis of the Metyrapone Short Test Using Targeted and Untargeted Metabolomics
Authors: Seoudy Anna Katharina , Schlicht Kristina , Kulle Alexandra , Demetrowitsch Tobias , Beckmann Alexia , Geisler Corinna , Türk Kathrin , Rohmann Nathalie , Hartmann Katharina , Brandes Juliane , Schulte Dominik M. , Schreiber Stefan , Schwarz Karin , Holterhus Paul-Martin , Laudes Matthias
Published: January 2023

Introduction: The present study aimed to prove the metyrapone short test in a day clinic to be suitable for examining the integrity of the hypothalamic-pituitary-adrenal (HPA) axis in patients with suspected secondary and tertiary adrenal insufficiency and to identify novel effector molecules in acute stress response. Methods: 44 patients were prospectively enrolled. Based on stimulated 11-deoxycortisol levels, patients were divided into a physiological (11-deoxycortisol ≥70 μg/L) and a pathological (11-deoxycortisol <70 μg/L) response group. Clinical follow-up examination was performed for validation. Ultraperformance liquid chromatography tandem mass spectrometry and a Fourier-transform-ion-cyclotron-resonance-mass-spectrometry were used for targeted and untargeted steroid metabolomics. Results: At baseline, lower levels of cortisone (42 vs. 50 nmol/L, p = 0.048) and 17-OH-progesterone (0.6 vs. 1.2 nmol/L, p = 0.041) were noted in the pathological response group. After metyrapone administration, the pathological response group exhibited significantly lower 11-deoxycortisol (39.0 vs. 94.2 μg/L, p < 0.001) and ACTH (49 vs. 113 pg/mL, p < 0.001) concentrations as well as altered upstream metabolites. Untargeted metabolomics identified a total of 76 metabolites to be significantly up- or downregulated by metyrapone. A significant increase of the bile acid glycochenodeoxycholic acid (GCDC, p < 0.01) was detected in both groups with an even stronger increase in the physiological response group. After a mean follow-up of 17.2 months, an 11-deoxycortisol cut-off of 70 µg/L showed a high diagnostic performance (sensitivity 100%, specificity 96%). Conclusion: The metyrapone short test is safe and feasible in a day clinic setting. The alterations of the bile acid GCDC indicate that the liver might be involved in the acute stress response of the HPA axis.
Effectiveness of STEAM-based blended learning on students’ critical and creative thinking skills
Authors: Putri Agnesi Sekarsari , Prasetyo Zuhdan Kun , Purwastuti Lusila Andriani , Prodjosantoso Anti Kolonial , Putranta Himawan
Published: January 2023

The critical and creative thinking skills of Indonesian students are relatively low from countries in the Malay family such as Malaysia and Singapore. This research aims to improve students’ critical and creative thinking skills through the use of Science, Technology, Engineering, Art, Mathematics (STEAM) based blended learning. This research is a quasi-experimental study using a nonequivalent pretest-posttest control-group design. The sample consists of 180 junior high school students in Yogyakarta, Indonesia. The samples in this study are 90 experimental class students and 90 control class students selected by random sampling cluster techniques because the selected samples come from individual groups or clusters. The instrument in this study consists of six questions in the form of essay questions. Test questions are analyzed using the gain score test and Kruskal-Wallis with SPSS 22. The results show steam-based blended learning can improve critical and creative thinking skills on all indicators with medium to high categories. The improvement of students’ critical and creative thinking skills in experimental classes is higher than that of the control class. In addition, there are differences in learning outcomes between control classes and experimental classes. STEAM-based blended learning can be an alternative for teachers to solve the problem of low critical and creative thinking skills.
The effect of entrepreneurial education on university student’s entrepreneurial self-efficacy and entrepreneurial intention
Authors: Atmono Dwi , Rahmattullah Muhammad , Setiawan Ananda , Mustofa Rochman Hadi , Pramudita Diaz Aziz , Ulfatun Titik , Reza Reza , Mustofa Achmad
Published: January 2023

The purpose of this study is to find out the impact of curriculum attendance (CA) and extracurricular activities (EA) on entrepreneurial self-efficacy (ESE) and entrepreneurial intentions (EI) in Indonesian students. This research is elaborated using the quantitative method with SEM-PLS to find out the studied phenomena. Decision questionnaires from questionnaires that have been used in previous studies. The questionnaire was responded to by 733 students who had studied entrepreneurship education during COVID-19 pandemic. The results showed that the presence of the curriculum attendance and extracurricular activities had a positive impact on entrepreneurial self-efficacy and entrepreneurial intentions. Extracurricular activities and entrepreneurial self-efficacy have a positive impact on entrepreneurial intentions. However, the presence of the curriculum has no impact on entrepreneurial intentions. This is the first step for universities and students to realize that the presence of the curriculum needs to be reconstructed in order to have an impact on entrepreneurial intentions.
Exploring curiosity and critical thinking skills for prospective biology teacher
Authors: Nurdiana Nurdiana , Hunaepi Hunaepi , Ikhsan Muhammad , Suwono Hadi , Sulisetijono Sulisetijono
Published: January 2023

Curiosity and critical thinking as one of the characteristics and skills developed in the goals of Indonesian education and 21st-century learning. Curiosity is a driving force for intrinsic motivation to explore behavior and gain new understanding and knowledge through observation. Curiosity and critical thinking skills are the needs of every individual to explore sciences such as biology. This study’s aim is to explore the curiosity and critical thinking skills of prospective biology teacher students. This research is a qualitative descriptive study with a survey method. The sample of this study amounted to 150 students who were taken using purposive random sampling. Curiosity data was collected using science curiosity in learning environments (SCILE) and critical thinking skills were collected using the developed instrument. The data obtained were analyzed using the partial least square program to determine the contribution of gender to scientific curiosity (SC) and critical thinking skills. The results of the analysis show that gender contributes directly to critical thinking skills through SC on the stretching indicator. In general, SC needs to do research to find out the contribution of each critical thinking.
Distance learning during COVID-19 pandemic: A study of Moroccan university students
Authors: Hafa Habiba , Hafa Badr , Moubtassime Mohammed
Published: January 2023

Because of COVID-19, distance learning was adopted by the majority of educational institutions as a strategy to ensure the continuity of education. In Morocco, forcing students to change their traditional learning methods has put them through an unprecedented learning experience. This study aims at investigating Moroccan university students of English experiences with distance learning during the pandemic in terms of readiness, satisfaction and perceived barriers. To achieve the objectives of the study, the researchers relied on an exploratory descriptive approach through a self-developed online questionnaire involving 138 respondents. The results indicate that students’ readiness to engage in distance learning was found to be at a moderate level. Additionally, the participants reported a low level of satisfaction with their experience of distance learning during COVID-19 pandemic. Thus, they preferred face-to-face learning over distance learning. Lack of previous experience with distance learning, lack of needed technology and inadequate internet connection were found to be among the major barriers to distance learning during the pandemic. Furthermore, the respondents expressed concerns on issues related to motivation, interaction and lack of technical skills. The findings of this study were discussed and compared to the findings of other related studies.
Students’ perception of emergency remote teaching in the Sultanate of Oman
Authors: Ramesh Gengatharan , Saranya Ramesh , Ebtehag Al-Harthy , Khalid Al-Badowi , Zweena Al-Habsi
Published: January 2023

During the coronavirus disease 2019 (COVID-19) pandemic, educational institutions adopted emergency remote teaching (ERT) practices. In ERT, courses are taught online by teachers who have experience with face-to-face classroom instruction. Students and teaching staff were concerned about the sudden change to ERT and learning practices. Higher education institutions (HEIs) need to understand students’ perceptions of ERT in order to prepare appropriate strategies for online teaching and learning. This study is intended: i) to analyze the students’ perception of ERT and ii) to explore the factors that determine the effectiveness of ERT during pandemic periods. The researchers used an online survey method to collect the primary data by employing a structured questionnaire. They employed the purposive sampling technique for this study. The results of the study highlight the fact that students prefer to take advantage of the available learning opportunities during the pandemic period. This is because they can earn their academic qualifications on time. It is also evident that the sudden transition to online teaching did compromise the efficacy of academic delivery to a certain extent. The study also found that motivation and assessment were crucial factors in determining the effectiveness of ERT during the pandemic period.
Understanding history, historical thinking, and historical consciousness, in learning history: An ex post-facto correlation
Authors: Bunari Bunari , Fadli Muhammad Rijal , Fikri Asyrul , Setiawan Johan , Fahri Ardian , Izzati Ikfi Muallifa
Published: January 2023

This study aims to analyze the relationship between historical understanding, historical thinking, towards historical consciousness in learning history. This type of research is ex post-facto with a correlational design. The population is class X high school students in Yogyakarta, with a sample of 177. The side technique uses cluster random sampling. Data collection uses instruments in the form of historical understanding tests, historical thinking tests, and historical consciousness questionnaires. Data analysis was carried out through partial correlation and multiple correlations with a significance level of 0.05, and the prerequisite test analysis used normality, linearity, and multicollinearity tests. The results show that the relationship between historical understanding, historical thinking, and historical consciousness in history learning has a strong and significant correlation. These three components should not be separated from the history learning process so that history learning is more meaningful for its historical values.
Design and development of critical thinking learning strategy in integral calculus
Authors: Shida Nurul , Abdullah Abdul Halim , Osman Sharifah , Ismail Norulhuda
Published: January 2023

Difficulty in understanding problem solving is due to the absence of critical thinking. Students lack knowledge in assessing critical thinking during problem solving. Hence, there is a need to study critical thinking infused through a learning strategy to enhance problem solving. Critical thinking (CThink) is a learning strategy designed which combines critical thinking and Integral Calculus. The development process of CThink combines the critical thinking process and questioning for critical thinking using the analysis, design, development, implementation, and evaluation (ADDIE) model. In the learning strategy, questions were applied based on CThink processes which consist of interpretation, analysis, inference, evaluation, explanation, and self-regulation. Besides, different questioning for CThink is presented based on the critical thinking process. CThink has achieved a content validity of 94.12% with a coefficient value of 0.94, and the value is above 70% or 0.70. Based on the result, the contents in the CThink are considered of good validity. From the calculation of the percentage from the expert given score, CThink has achieved the validity measurement for the language of 97.50% with a coefficient value of validity is 0.975, which is above 70 or 0.70. Based on the result, the activities and syllabus used in CThink achieved good validity measurements. The experts concluded that this CThink meets the content of Integral Calculus, in line with the level of polytechnic students, allowing students to think critically to solve problems as well as activities in CThink help to enhance student problem solving.
A comparing key performance indicator and benchmarks of quality pre-school among the agency in Malaysia
Authors: Mamat Nordin , Razali Abdul Rahim , Hashim Abdul Talib , Awang Mohd Mahzan , Azman Mohamed Nor Azhari , Fajrie Nur
Published: January 2023

High quality early childhood education (ECE) enables children to enjoy the experience and have nurturing environment that promotes holistic development. The key performance indicators such as quality pre-school’s environment, teachers and assistant teachers, learning materials have been predicted to produce desirable outcomes. However, the challenge is to identify the predictors that can quantify the definition of a quality teacher. This study uses questionnaire to assess individual perceptions and views on quality key performance indicators of early childhood pre-school center. The study’s findings revealed that the gap analysis related to the qualification of pre-school teachers and ratio teacher-child below the standard. Even though teacher-child ratio in private pre-schools is small because most of pre-schools do not employ assistant teacher as practiced in other pre-schools. Thus, the study found that the performance of children’s abilities in Ministry of Education pre-school and private pre-schools exceeded the national standard of 76.2% National Average of Reading and Writing, and 64.6% National Average of Arithmetic. However, based on benchmark 100% achievement, the screening performance report shown children far left behind. In conclusion, these findings are important to be given attention and remedial action in order the improvement and quality of pre-school achieve the minimum standard.
Strengthening character education planning based on Pancasila value in the international class program
Authors: Maisyaroh Maisyaroh , Untari Sri , Chusniyah Tutut , Adha Maulana Amirul , Prestiadi Dedi , Ariyanti Nova Syafira
Published: January 2023

Education programs planned and implemented in schools have a great impact on the forming of the student’s character and intelligence. This study aims to describe the planning of management to strengthen character education based on Pancasila values in the international class program at laboratory elementary school (Labschool) Universitas Negeri Malang (UM). Qualitative research with a case study research design is used in this study. The data was obtained through unstructured interviews with principals, teachers, education personnel, school committees, and stakeholder. All information is tested for credibility and validity through triangulation. The results of this study showed that planning activities in character education strengthening programs are divided into aspects of learning and non-learning. The formulation of the school's vision and mission is used as the basis for implementing character education in schools, by adjusting learning characteristics that refer to western education patterns, which are combined with eastern culture as outlined in student character-building activities. The impact of implementing school strategies in strengthening student character is inherent in students’ daily lives, both in the environment where they live and in their school environment, and continues to carry over into adulthood.
Possível tradução de poemas de Assunta Renau Ferrer
Authors: Lopes Tania Mara Antonietti
Published: January 2023

Este artigo trata de uma proposta de tradução para alguns poemas de Assunta Renau Ferrer, poeta da Guiana Francesa, de seu livro Mon coeur est une mangrove, publicado em 1996. A base teórica dos Estudos de Tradução utilizada parte das ideias de André Lefevère (2012) e de Itamar Even-Zohar (2012). Meu objetivo é apresentar a poeta guianense a partir de seus poemas que, traduzidos para o português, podem proporcionar o interesse por uma literatura diversa da nossa e ampliar o campo de pesquisa tanto dos Estudos da Tradução quanto dos Estudos Literários.
Os apólogos de Vigílias negras, de Léon-Gontran Damas
Authors: Costa Daniel Padilha Pacheco da
Published: January 2023

Neste artigo, discuto o lugar especial ocupado pela única obra em prosa ficcional do escritor guianense Léon-Gontran Damas, intitulada Veillées noires. Contes nègres de Guyane (1943), no interior do seu projeto literário e político. Segundo a “ideologia da revalorização africana” própria ao movimento da Negritude, Veillées noires (Vigílias negras) retoma um dos mais importantes gêneros narrativos das culturas orais africanas e crioulas: o conto tradicional. O título “Vigílias negras” metaforiza o contexto original de performance desses contos orais tradicionais oriundos da bacia amazônica da Guiana Francesa e transmitidos pela personagem da anciã “Tètèche”, condensando os seus diferentes sentidos políticos, culturais e telúricos. Como essa coletânea de contos permanece inédita em língua portuguesa, proponho uma tradução dos seus quatro minicontos ou microcontos que, podendo ser considerados “apólogos”, intitulam-se “Palabre” (Bate-papo), “Mystère” (Mistério), “Astuce” (Astúcia) e “Aux premiers âges” (Nos primeiros anos).
A Medalha, de Marie-Thérèse Picard
Authors: Silva-Reis Dennys , Bagno Marcos
Published: January 2023

Marie-Thérèse Picard é guianense que reside há muitos anos em Guadalupe. É professora e ama o desenvolvimento da capacidade de aprendizagem. Em 1991, fundou em Pointe-à-Pitre o Centro de estudo Polivalente, uma associação de reforço escolar. Igualmente é escultora e pintora, tendo exposto suas obras na Guiana e em Paris. Já na literatura, dedica sua escrita à dramaturgia infanto-juvenil, tendo escrito Ourson (2009), La Médaille (2011) e L’enfant (2013). Por todos esses textos já foi premiada em diversas categorias pelo Prêmio de escrita teatral contemporânea no Caribe – ETC-Caraïbe. A presente tradução ao português tem por objetivo apresentar um texto guianense infantil ao público brasileiro. O texto aparenta ser pragmático e direto pela voz de crianças. Entretanto, traz nas entrelinhas temas bastante contemporâneos: a violência, o machismo, a distinção de gênero, o determinismo familiar, o feminicídio. Tudo isso atrelado ao mundo imaginário da criança e ao contato desta com o seu tutor responsável.
“A Guiana permanece no coração do meu trabalho” – Entrevista com Catherine Le Pelletier
Authors: Rocha Vanessa Massoni da , Pelletier Catherine Le , Jesus Cássia de
Published: January 2023

Catherine Le Pelletier é doutora em letras e professora associada pela Universidade das Antilhas. Na entrevista concedida à Vanessa Massoni da Rocha, a intelectual de origem guianense aborda – de maneira didática e generosa – temas importantes do universo literário da Guiana. Localizada na América do Sul, mais precisamente entre o Suriname e o Brasil, a Guiana é um departamento francês ultramarino desde 1946.
Le théâtre Guyanais contemporain: entretien avec Odile Pedro Leal
Authors: Leal Odile Pedro , Ribeiro Rosária Cristina Costa
Published: January 2023

Comédienne, formée au Conservatoire National Supérieur de Bordeaux, metteure en scène, auteure dramatique et directrice artistique du Grand Théâtre Itinérant de Guyane (Grand T.I.G), qui succède depuis 2017 au Guyane Art Théâtre, aussi Chargée de mission culturelle dans le Conseil Régional de Guyane entre 2010 et 2012, nous pouvons dire que Odile Pedro Leal est une femme multiple, comme la Guyane, comme le théâtre guyanais. Dans sa thèse de doctorat, Mme Pedro Leal développe le concept du théâtre caché-montré, un théâtre présent au quotidien guyanais, surtout concentré autour du Carnaval: «Le carnaval est un théâtre caché, parce qu’il se passe du tréteau ou de la scène, comme du professionnalisme de l’acteur, pour sa réalisation; et il est un théâtre montré, parce que visiblement on y joue.» (PEDRO LEAL, 2000, p. 37).
Entre o fantástico e a realidade, a história guianense segundo Michel Lohier através de suas Lendas e Contos folclóricos da Guiana
Authors: Raad Marie-Simone , Gois Lucas Ferreira
Published: January 2023

Neste artigo, proponho-me a mostrar como Michel Lohier, autor guianense do século XX, consegue apoderar-se da história guianense a fim de introduzi-la em seus contos e lendas. Este último mistura a fantasia com a realidade através de crenças fantasmagóricas. As narrativas de Lohier ilustram ao mesmo tempo o sistema colonial e a alienação do colono europeu sobre o homem negro. Por meio da alegoria, assistimos a um confronto entre o escravo e o mestre. Neste sentido, o leitor torna-se testemunha de uma luta sem tréguas entre a astúcia e a inteligência dos mais fracos contra a estupidez e a maldade, e até mesmo a cobiça, dos mais fortes, o que acentua, por conseguinte, o questionamento do poder colonial. Esse combate simboliza assim a vitória do escravo sobre o colono, levando dessa forma à dessacralização deste último. Na reflexão proposta, tratar-se-á de mostrar como o mundo colonial é representado através do imaginário e, sobretudo, como a história da Guiana é apresentada. Portanto, será necessário estudar a forma como se desenrola toda uma lição de História através de uma simples narrativa, e também nos atentarmos à cenografia encantadora própria do universo dos contos guianenses.
Viagem pelas águas da Guiana Francesa na voz de duas poetas: Eugénie Rézaire e Assunta Renau Ferrer
Authors: Pinheiro-Mariz Josilene
Published: January 2023

Neste artigo busco apresentar e discutir a minha tradução de três poemas de duas poetas que escrevem em língua francesa: Eugénie Rézaire e Assunta Renau Ferrer, mesmo em um país em que há a presença de outras línguas, a Guiana Francesa. Levo em consideração que se trata de uma literatura que em muitos aspectos assemelha-se à brasileira; mas, parece estar distante do leitor das nossas fronteiras. Ancorada em um pensamento que descreve a guianidade nessa produção literária (SILVA-REIS, 2021) e na importância da lírica feminina, com suas características que vão vazão a pensar sobre o anticolonialismo, bem como a própria identidade do povo da Guiana e ainda enfocando as reivindicações que vieram com o desfecho da escravidão e da colonização, na ótica de três autores literários da Guiana Francesa (STEPHENSON; PATIENT; PARADIS, 2008), discuto a tradução dos três poemas e minhas escolhas tradutórias. Antes, no entanto, apresento o corpus que acolhe os poemas traduzidos, a antologia Outremer: trois océans en poésie e discuto noções como a francofonia e o seu lugar na atualidade.
Heart‐Brain Team Approach of Acute Myocardial Infarction Complicating Acute Stroke: Characteristics of Guideline‐Recommended Coronary Revascularization and Antithrombotic Therapy and Cardiovascular and Bleeding Outcomes
Authors: Suzuki Toshiaki , Kataoka Yu , Shiozawa Masayuki , Morris Kensuke , Kiyoshige Eri , Nishimura Kunihiro , Murai Kota , Sawada Kenichiro , Iwai Takamasa , Matama Hideo , Honda Satoshi , Fujino Masashi , Yoneda Shuichi , Takagi Kensuke , Otsuka Fumiyuki , Asaumi Yasuhide , Koga Masatoshi , Ihara Masafumi , Toyoda Kazunori , Tsujita Kenichi , Noguchi Teruo
Published: January 2023

Background

Acute myocardial infarction (AMI) infrequently occurs after acute stroke. The Heart‐brain team approach has a potential to appropriately manage this poststroke cardiovascular complication. However, clinical outcomes of AMI complicating acute stroke (AMI‐CAS) with the heart‐brain team approach have not been characterized. The current study investigated cardiovascular outcomes in patients with AMI‐CAS managed by a heart‐brain team.

Methods and Results

We retrospectively analyzed 2390 patients with AMI at our institute (January 1, 2007–September 30, 2020). AMI‐CAS was defined as the occurrence of AMI within 14 days after acute stroke. Major adverse cerebral/cardiovascular events (cardiac‐cause death, nonfatal myocardial infarction, and nonfatal stroke) and major bleeding events were compared in subjects with  AMI‐CAS and those without acute stroke. AMI‐CAS was identified in 1.6% of the subjects. Most AMI‐CASs (37/39=94.9%) presented ischemic stroke. Median duration of AMI from the onset of acute stroke was 2 days. Patients with AMI‐CAS less frequently received primary percutaneous coronary intervention (43.6% versus 84.7%;
P
<0.001) and dual‐antiplatelet therapy (38.5% versus 85.7%;
P
<0.001), and 33.3% of them did not receive any antithrombotic agents (versus 1.3%;
P
<0.001). During the observational period (median, 2.4 years [interquartile range, 1.1–4.4 years]), patients with AMI‐CAS exhibited a greater likelihood of experiencing major adverse cerebral/cardiovascular events (hazard ratio [HR], 3.47 [95% CI, 1.99–6.05];
P
<0.001) and major bleeding events (HR, 3.30 [95% CI, 1.34–8.10];
P
=0.009). These relationships still existed even after adjusting for clinical characteristics and medication use (major adverse cerebral/cardiovascular event: HR, 1.87 [95% CI, 1.02–3.42];
P
=0.04; major bleeding: HR, 2.67 [95% CI, 1.03–6.93];
P
=0.04).

Conclusions

Under the heart‐brain team approach, AMI‐CAS was still a challenging disease, reflected by less adoption of primary percutaneous coronary intervention and antithrombotic therapies, with substantially elevated cardiovascular and major bleeding risks. Our findings underscore the need for a further refined approach to mitigate their ischemic/bleeding risks.
Phonetic and Phono-Lexical Accuracy of Non-Native Tone Production by English-L1 and Mandarin-L1 Speakers
Authors: Laméris Tim Joris , Li Katrina Kechun , Post Brechtje
Published: January 2023

Lexical tones are known to be a challenging aspect of speech to acquire in a second language, but several factors are known to affect tone learning facility, such as L1 tonal status (whether a learner’s L1 is tonal or not), tone type (the shape of the tones to be acquired), and individual extralinguistic factors (such as musicianship, pitch aptitude, and working memory). Crucially, most of our knowledge of the effect of these factors is based on evidence from perception. The production side of tone learning and the origins of individual variability in learning facility remain relatively understudied. To this end, this study investigated non-native tone production—both in terms of phonetic accuracy in a pseudoword imitation task and in terms of phono-lexical accuracy in a picture-naming task—by English-L1 and Mandarin-L1 speakers. Results show that L1 tonal status and tone type dynamically affected both imitation and picture-naming accuracy, as there were specific accuracy patterns for the English and Mandarin groups. Production accuracy was further facilitated by individual musical experience, working memory, and pitch aptitude. This study’s findings add to the currently limited literature on how both language-specific and individual extralinguistic factors modulate non-native tone processing in the speaking modality.
Signaling High Sensitivity to Influence Others: Initial Evidence for the Roles of Reinforcement Sensitivity, Sensory Processing Sensitivity, and the Dark Triad
Authors: Kajdzik Martyna , Moroń Marcin
Published: January 2023

Signaling high sensitivity to others may help individuals with heightened sensitivity to stimuli to craft their social relations to a preferred activation level (“assertive signaling of specific needs” hypothesis). Signaling sensitivity could be also a deceptive strategy helping to extract resources or obtain the desired treatment (“deceptive signaling” hypothesis). The study presents the construction of the measure of signaling high sensitivity to influence others and an initial test of both hypotheses. Two hundred and one participants ranging in age from 18 to 67 ( M = 25.6; SD = 7.03) reported on their reinforcement sensitivity (behavioral approach and inhibition system), sensory processing sensitivity, and the Dark Triad. Signaling high sensitivity to influence others was weakly, but significantly, associated with behavioral inhibition system sensitivity, which was consistent with the “assertive signaling of specific needs” hypothesis. The behavioral approach system was positively correlated with signaling high sensitivity, which indicated that this influence strategy could be treated as an assertive self-presentational strategy helping in achieving social rewards for individuals with high reward responsiveness. Narcissism and psychopathy accounted for an additional amount of variance in signaling high sensitivity over and beyond reinforcement sensitivity. This was consistent with the “deceptive signaling” hypothesis. Signaling high sensitivity could be regarded as a strategy to achieve social goals using deception rather than as an expression of sensitive personality.
Are Mindfulness and Mind-Wandering Opposite Constructs? It Depends on How Mindfulness is Conceptualised
Authors: Somaraju Lakshmi H. , Temple Elizabeth C. , Cocks Bernadine , Bizo Lewis A.
Published: January 2023

This study investigated if trait mindfulness and its components, mindful attention, acceptance, and non-judging correlate negatively with self-reported and indirect markers of mind-wandering. The 552 participants of the study completed an anonymous online questionnaire consisting of trait mindfulness and mind-wandering scales. They also completed the computer-based Sustained Attention to Response Task (SART), an objective measure of mind-wandering. The total mindfulness score and acceptance and non-judging subscale scores were strongly negatively correlated with both self-reported trait mind-wandering (TMW) and SART indices of mind-wandering. In contrast, attention was significantly positively correlated with both. These findings suggest that trait mindfulness conceptualised as a multi-component construct, but not a uni-component one, is probably an opposing construct to trait mind-wandering. Furthermore, mindfulness and its components, acceptance and non-judging, are associated with a reduction in the more common form of SART errors. However, only the acceptance component made a unique contribution to the variance in TMW and SART performance. Therefore, it is advisable for researchers to specify whether they investigated mindfulness as a uni-component or multi-component construct. Furthermore, it would be beneficial if future research investigates the relationship of mindfulness and its components with mind-wandering further by also incorporating a measure of state mindfulness.
A review of wearable carbon-based sensors for strain detection: fabrication methods, properties, and mechanisms
Authors: Zhang Yingying , Xiao Qiyue , Wang Qiuyan , Zhang Yan , Wang Ping , Li Yuanyuan
Published: January 2023

Carbon-based flexible wearable sensors have received widespread attention due to their wide application in wearable electronics. This work reviewed the different carbon-based sensors from three aspects, such as fabrication, performance and working mechanisms. Carbon materials mainly included carbon nanotubes, graphene, carbon black and other carbon materials. In particular, carbon nanotubes and graphene can be assembled into various multiscale macrostructures to prepare various forms of flexible sensors, such as films, fibers, yarns or fabrics. Up to now, the reviewed flexible strain sensors in general exhibit high sensitivity, wide sensing range, fast response, long-term stability and durability. However, in the face of complex environmental and multifunctional integration in practical applications, wearable strain sensors need new technological breakthroughs in the preparation process, material synthesis and device integration.
Public Health Awareness Campaigns in Otolaryngology: Are We Making an Impact?
Authors: Kang Joshua M. , Coelho Daniel H.
Published: January 2023

Objective

To determine if public awareness campaigns in Otolaryngology—Head and Neck Surgery are influencing public interest, as measured by internet searches.

Study Design

Database Query.

Setting

Internet.

Methods

Six awareness campaigns were analyzed over 5 years (2016–2020). Each campaign was assigned one or more relevant Google search terms/topics. Weekly data on United States internet search queries for these topics/terms were collected from Google Trends. “Campaign” dates were defined as 1 week before and 2 weeks after any awareness “day” or “week,” and 2 weeks prior and 2 weeks after any awareness “month.” “Non-campaign” weeks were considered any data outside the “campaign” window. A Welch’s unpaired t-test was used to determine statistically significant differences between “campaign” dates and “non-campaign” dates.

Results

Of the awareness campaigns studied, only “Kids ENT Health Month” (search topic “adenoidectomy,” P = < .001) and “Cochlear Implant Day” (search topic “cochlear implant,” P = .004615) demonstrated a significant increase in internet search activity during the time frame of interest between 2016 and 2020. Although there were some individual years with significant increases for select search terms/topics corresponding to their campaign of interest, none of the campaigns showed increases over the 5-year period studied.

Conclusion

Public health advocacy and outreach has long been recognized as an important component of optimizing otolaryngologic care. However, such efforts to increase public awareness may have varying or even minimal impact. Though an imperfect tool, data from Google Trends suggests that with few exceptions, awareness campaigns in otolaryngology do not necessarily translate to increased internet searches.
A Rare Case of Double Pyramidal Lobe of the Thyroid Gland
Authors: Vithana Sanura Malinda Pallegoda , Rajakaruna Roshan Chaminda Bandara
Published: January 2023

The pyramidal lobe is an anatomical component of the thyroid gland seen in up to 65% of individuals. It represents the distal, nondegenerate part of the thyroglossal duct. The double pyramidal lobe is a very rare occurrence, and this is the first reported case in Sri Lanka. A 40-year-old woman presented a long-standing goiter. Her evaluation revealed a benign multinodular goiter with a dominant right colloid nodule and background thyroiditis. She was euthyroid and had no compressive symptoms. Considering cosmesis, the patient opted for total thyroidectomy during which two pyramidal lobes were identified. The rest of the thyroid gland and the parathyroids had no anomalies. After an uneventful postoperative stay, she was discharged later. This is a very rare case where the patient had two separate pyramidal lobes; a phenomenon documented in less than 10 cases around the world. In addition to embryology, the pyramidal lobe has significance in clinical practice. It can be associated with benign and malignant disease of the thyroid; focal and diffuse. Incomplete removal may result in recurrence of the disease in the remaining thyroid tissue of the pyramidal lobe. Therefore, active inspection of the lobe including its anatomy during thyroid surgery and complete excision when indicated is of paramount importance.
The platformization of misogyny: Popular media, gender politics, and misogyny in China’s state-market nexus
Authors: Liao Sara
Published: January 2023

This study aims to map out the popular phenomenon of misogyny in the specific techno-social configuration buttressed by China’s state-market nexus. With a case study of a controversy involving the standup comedian Yang Li and the luxury car brand Mercedes-Benz on the microblogging platform Weibo, I highlight the ‘platformization of misogyny.’ The conceptualization refers to the way that a platform is evoked as tools to manufacture and amplify misogyny. Weibo has this effect both through its design, features, and algorithmic shaping of sociality and through its users’ appropriation of its affordances. On top of that, the platform also engenders a form of governance that is deeply enmeshed in the commercialization of internet opinion, suggesting a techno-nationalist mode of state control that is exercised from afar and deeply imbued with patriarchal and misogynistic characteristics.