bluuebunny/crossref_metadata_2025 huggingface dataset:
A genomic exploration identifies mechanisms that may explain adverse cardiovascular effects of COX-2 inhibitors
Authors: Brænne Ingrid , Willenborg Christina , Tragante Vinicius , Kessler Thorsten , Zeng Lingyao , Reiz Benedikt , Kleinecke Mariana , von Ameln Simon , Willer Cristen J. , Laakso Markku , Wild Philipp S. , Zeller Tanja , Wallentin Lars , Franks Paul W. , Salomaa Veikko , Dehghan Abbas , Meitinger Thomas , Samani Nilesh J. , Asselbergs Folkert W. , Erdmann Jeanette , Schunkert Heribert
Published: August 2017

Cyclooxygenase-2 inhibitors (coxibs) are characterized by multiple molecular off-target effects and increased coronary artery disease (CAD) risk. Here, we systematically explored common variants of genes representing molecular targets of coxibs for association with CAD. Given a broad spectrum of pleiotropic effects of coxibs, our intention was to narrow potential mechanisms affecting CAD risk as we hypothesized that the affected genes may also display genomic signals of coronary disease risk. A Drug Gene Interaction Database search identified 47 gene products to be affected by coxibs. We traced association signals in 200-kb regions surrounding these genes in 84,813 CAD cases and 202,543 controls. Based on a threshold of 1 × 10−5 (Bonferroni correction for 3131 haplotype blocks), four gene loci yielded significant associations. The lead SNPs were rs7270354 (MMP9), rs4888383 (BCAR1), rs6905288 (VEGFA1), and rs556321 (CACNA1E). By additional genotyping, rs7270354 at MMP9 and rs4888383 at BCAR1 also reached the established GWAS threshold for genome-wide significance. The findings demonstrate overlap of genes affected by coxibs and those mediating CAD risk and points to further mechanisms, which are potentially responsible for coxib-associated CAD risk. The novel approach furthermore suggests that genetic studies may be useful to explore the clinical relevance of off-target drug effects.
Rising tides, cumulative impacts and cascading changes to estuarine ecosystem functions
Authors: O’Meara Theresa A. , Hillman Jenny R. , Thrush Simon F.
Published: August 2017

In coastal ecosystems, climate change affects multiple environmental factors, yet most predictive models are based on simple cause-and-effect relationships. Multiple stressor scenarios are difficult to predict because they can create a ripple effect through networked ecosystem functions. Estuarine ecosystem function relies on an interconnected network of physical and biological processes. Estuarine habitats play critical roles in service provision and represent global hotspots for organic matter processing, nutrient cycling and primary production. Within these systems, we predicted functional changes in the impacts of land-based stressors, mediated by changing light climate and sediment permeability. Our in-situ field experiment manipulated sea level, nutrient supply, and mud content. We used these stressors to determine how interacting environmental stressors influence ecosystem function and compared results with data collected along elevation gradients to substitute space for time. We show non-linear, multi-stressor effects deconstruct networks governing ecosystem function. Sea level rise altered nutrient processing and impacted broader estuarine services ameliorating nutrient and sediment pollution. Our experiment demonstrates how the relationships between nutrient processing and biological/physical controls degrade with environmental stress. Our results emphasise the importance of moving beyond simple physically-forced relationships to assess consequences of climate change in the context of ecosystem interactions and multiple stressors.
Is there a frontier in sensitivity with Lossy mode resonance (LMR) based refractometers?
Authors: Ozcariz Aritz , Zamarreño Carlos R. , Zubiate Pablo , Arregui Francisco J.
Published: August 2017

A tin dioxide thin layer has been studied in order to improve the sensitivity of lossy mode resonances (LMR) based sensors. The effects of the thin film thickness and the polarization of light in a SnO2 coated D-shaped single mode optical fiber have been evaluated. The optimization of such parameters in the fabrication of refractometers have led to an unprecedented sensitivity of over one million nanometers per refractive index unit (RIU), which means a sensitivity below 10−9 RIU with a pm resolution detector. This achievement is a milestone for the development of new high sensitivity devices and opens the door to new industrial applications, such as gear oil degradation, or biomedical devices where previous devices could not provide enough sensitivity.
Determining rotational dynamics of the guanidino group of arginine side chains in proteins by carbon-detected NMR
Authors: Gerecht Karola , Figueiredo Angelo Miguel , Hansen D. Flemming
Published: August 2017

A new NMR-based method is presented to determine the rotational dynamics around the Nε–Cζ bond of arginine to characterise the interactions mediated by arginine side chains.
Enhancement of the photocatalytic activity of rhenium(i) complexes by encapsulation in light-harvesting soft nanotubes
Authors: Kameta Naohiro , Aoyagi Masaru , Asakawa Masumi
Published: August 2017

The photocatalytic activity of a Re(i) complex encapsulated in dye-assembled nanotubes functioning as light-harvesting antennae was superior to that of a free Re(i) complex in bulk.
Regioselective hydrogenolysis of aryl ether C–O bonds by tungsten carbides with controlled phase compositions
Authors: Fang Huihuang , Du Junmou , Tian Chenchen , Zheng Jianwei , Duan Xinping , Ye Linmin , Yuan Youzhu
Published: August 2017

Evenly dispersed tungsten carbides with controlled phase compositions that exhibit an impressive capacity to carry out the regioselective hydrogenolysis of inert aryl ether C–O bonds instead of aliphatic C–O bonds to produce aromatic compounds are reported.
Iodine-doped sumanene and its application for the synthesis of chalcogenasumanenes and silasumanenes
Authors: Tan Qitao , Zhou Dandan , Zhang Tao , Liu Bingxin , Xu Bin
Published: August 2017

The first example of halogen-doped buckybowls has been synthesized, which can be readily transformed into pristine trithiasumanene, triselenasumanene and trisilasumanene.
Co3O4–SnO2 nanobox sensor with a PN junction and semiconductor–conductor transformation for high selectivity and sensitivity detection of H2S
Authors: Jiang Pengjie , Zhang Haonan , Chen Changmiao , Liang Jiaojiao , Luo Yazi , Zhang Ming , Cai Mengqiu
Published: August 2017

Uniform Co3O4–SnO2 nanoboxes have been synthesized successfully by a facile annealing treatment.
Self-assembly of new M(ii) coordination polymers based on asymmetric 1,3,4-oxadiazole-containing ligands: effect of counterions and magnetic properties
Authors: Wu Xiang-Wen , Pan Feng , Zhang Dong , Jin Guo-Xia , Ma Jian-Ping
Published: August 2017

A construction strategy of high dimensional porous coordination polymers has been investigated based on two unsymmetrical ligands and “naked” and coordinated metal ions.
A novel assessment of the role of the methyl radical and water formation channel in the CH3OH + H reaction
Authors: Sanches-Neto Flávio O. , Coutinho Nayara D. , Carvalho-Silva Valter H.
Published: August 2017

A number of experimental and theoretical papers accounted almost exclusively for two channels in the reaction of atomic hydrogen with methanol. However, several astrochemical studies claimed the importance of another channel for this reaction.
Ionic effects on the proton transfer mechanism in aqueous solutions
Authors: Joung Joonyoung F. , Kim Sangin , Park Sungnam
Published: August 2017

Proton dissociation (PD) reactions of weak acids and proton transfer (PT) processes in aqueous solutions are strongly influenced by ions.
Anharmonic vibrational effects in linear and two-dimensional electronic spectra
Authors: Galestian Pour Arpa , Lincoln Craig Norman , Perlík Václav , Šanda František , Hauer Jürgen
Published: August 2017

Anharmonic modulation of electronic gap is manifested in changing magnitudes of cross peaks of 2D electronic spectrum.
Quantum dots in photocatalytic applications: efficiently enhancing visible light photocatalytic activity by integrating CdO quantum dots as sensitizers
Authors: Reshak A. H.
Published: August 2017

The amalgamation of a wide optical band gap photocatalyst with visible-light-active CdO quantum dots (QDs) as sensitizers is one of the most efficient ways to improve photocatalytic performance under visible light irradiation.
Structure-dependent reactivity of Criegee intermediates studied with spectroscopic methods
Authors: Jr-Min Lin Jim , Chao Wen
Published: August 2017

Criegee intermediates can be prepared by two methods and may play important roles in atmospheric chemistry. Anti-type Criegee intermediates react quickly with water dimer; Syn-type Criegee intermediates may undergo thermal decomposition via intramolecular hydrogen atom tunneling. In addition, the pros and cons of each spectroscopic method in probing Criegee intermediates in kinetic experiments will also be discussed.
On the role of the alkali cations on methanol thiolation
Authors: Bermejo-Deval Ricardo , Walter Raimund M. H. , Gutiérrez Oliver Y. , Lercher Johannes A.
Published: August 2017

The electronegativity effect of the alkali cations on the formation of methanethiol by reaction of methanol and H2S was studied with K+, Rb+, and Cs+ supported on γ-Al2O3.
One-pot synthesis of optically pure β-hydroxy sulfones via a heterogeneous ruthenium/diamine-promoted nucleophilic substitution-asymmetric transfer hydrogenation tandem process
Authors: Wang Jinyu , Wu Liang , Hu Xiaoying , Liu Rui , Jin Ronghua , Liu Guohua
Published: August 2017

Chiral ruthenium/diamine-functionalized mesoporous silica is synthesized and its application in the one-pot synthesis of chiral β-hydroxy sulfones is investigated.
A new superacid hafnium-based metal–organic framework as a highly active heterogeneous catalyst for the synthesis of benzoxazoles under solvent-free conditions
Authors: Nguyen Linh H. T. , Nguyen The T. , Nguyen Ha L. , Doan Tan L. H. , Tran Phuong Hoang
Published: August 2017

A new superacid Hf-based MOF, termed VNU-11-P-SO4, was used as an efficient heterogeneous catalyst for solvent-free 2-arylbenzoxazole synthesis.
Transfer of chiral information from a chiral solvent to a two-dimensional network
Authors: Destoop Iris , Minoia Andrea , Ivasenko Oleksandr , Noguchi Aya , Tahara Kazukuni , Tobe Yoshito , Lazzaroni Roberto , De Feyter Steven
Published: August 2017

Chiral induction in self-assembled monolayers has garnered considerable attention in the recent past, not only due to its importance in chiral resolution and enantioselective heterogeneous catalysis but also because of its relevance to the origin of homochirality in life. Here, we demonstrate the emergence of homochirality in a supramolecular low-density network formed by achiral molecules at the interface of a chiral solvent and an atomically-flat achiral substrate. We focus on the impact of structure and functionality of the adsorbate and the chiral solvent on the chiral induction efficiency in self-assembled physisorbed monolayers, as revealed by scanning tunneling microscopy. Different induction mechanisms are proposed and evaluated, with the assistance of advanced molecular modeling simulations.
Influence of transition metal (Fe, Co, and Ag) doping on the MnOx–CeO2/Ti-bearing blast furnace slag catalyst for selective catalytic reduction of NOx with NH3 at low temperature
Authors: Liu Rong , Xu Yifan , Ye Fei , Jia Feng , Xu Rui
Published: August 2017

Mn–Ce based catalysts supported on Ti-bearing blast furnace slag (industrial solid waste) and the doping of transition metals were studied.
Facile size-controllable synthesis process, bandgap blue shift, and enhanced photocatalytic performances of [111]-faceted anatase TiO2 nanocrystals
Authors: Xu Linfeng , Sewvandi Galhenage A. , Uemura Shinobu , Kusunose Takafumi , Nakanishi Shunsuke , Feng Qi
Published: August 2017

The blue shift of TiO2 nanocrystals is dependent on the facet exposed on the surface, increasing in the order of non-facet < [111]-facet < {010}-facet.
Facile synthesis of perovskite-type NdNiO3 nanoparticles for an effective electrochemical non-enzymatic glucose biosensor
Authors: Sivakumar Mani , Pandi Karuppiah , Chen Shen-Ming , Cheng Yi-Hui , Sakthivel Mani
Published: August 2017

The detailed facile synthesis and material characterizations of NdNiO3 nanoparticles for a non-enzymatic glucose sensor application were discussed briefly in this paper.
Graphene coated Co3V2O8 micro-pencils for enhanced-performance in lithium ion batteries
Authors: Wu Mengqiang , Yang Jian , Feng Tingting , Jiang Weiwei , Xia Dawei , Gong Feng , Liao Jiaxuan
Published: August 2017

The graphene composites effectively improve the electrochemical performance of the pencil like Co3V2O8.
Fabrication and characterization of mid-infrared emission of Pr3+ doped selenide chalcogenide glasses and fibres
Authors: Liu Zijun , Bian Junyi , Huang Yan , Xu Tiefeng , Wang Xunsi , Dai Shixun
Published: August 2017

Mid-infrared (2.8–5.5 μm) Pr3+ (2050 ppmw) doped fibres were obtained and characterized under the pump of a 2.0 μm laser.
Promotion of hydrogenation activity and sulfur resistance over Ni/ASA catalyst by support modification simultaneously with P and USY
Authors: Cui Sha , Ge Jiaqi , Wang Genggeng , Yang Ying , Liu Baijun
Published: August 2017

Compared to Ni/ASA (Cat), individual and simultaneous P and USY promoted ASA supported Ni catalysts display higher naphthalene hydrogenation activity, especially the simultaneous P and USY promoted catalyst.
Larvicidal, super hydrophobic and antibacterial properties of herbal nanoparticles from Acalypha indica for biomedical applications
Authors: S. Karthik , R. Suriyaprabha , M. Vinoth , S. R. Srither , P. Manivasakan , V. Rajendran , Valiyaveettil Suresh
Published: August 2017

Herbal nanoparticles usingAcalypha indicaleaves are investigated and found to possess superior larvicidal, water repellent and antimicrobial properties for biomedical applications.
Preparation and biocompatibility of electrospinning PDLLA/β-TCP/collagen for peripheral nerve regeneration
Authors: Lin Fei , Wang Xinyu , Wang Yiyu , Yang Yushi , Li Yi
Published: August 2017

A unique nerve conduit composed of poly(d,l-lactic acid) (PDLLA), β-tricalcium phosphate (β-TCP) and collagen was prepared by electrospinning for the first time.
Growth of single-crystalline cubic structured tin(ii) sulfide (SnS) nanowires by chemical vapor deposition
Authors: Mudusu Devika , Nandanapalli Koteeswara Reddy , Dugasani Sreekantha Reddy , Kang Jang Won , Park Sung Ha , Tu Charles W.
Published: August 2017

SnS nanowires with high aspect-ratio were developed by chemical vapor deposition and their physical and chemical properties were explored, along with their field effect transistor characteristics.
Transformation and dehydration kinetics of methylene blue hydrates detected by terahertz time-domain spectroscopy
Authors: Yan Shihan , Zhang Hua , Yang Zhongbo , Tang Mingjie , Zhang Mingkun , Du Chunlei , Cui Hong-Liang , Wei Dongshan
Published: August 2017

Three methylene blue crystalline hydrates were identified by terahertz spectroscopy according to their different THz absorption features.
Pinecone biomass-derived hard carbon anodes for high-performance sodium-ion batteries
Authors: Zhang Tao , Mao Jing , Liu Xiaolin , Xuan Minjie , Bi Kai , Zhang Xiao Li , Hu Junhua , Fan Jiajie , Chen Shimou , Shao Guosheng
Published: August 2017

Hard-carbon is considered as one of the most promising anode materials for sodium-ion batteries (SIBs).
Construction and evaluation of chemical structure model of Huolinhe lignite using molecular modeling
Authors: Xu Fang , Pan Shuo , Liu Chunguang , Zhao Deng , Liu Hui , Wang Qing , Liu Ying
Published: August 2017

A lignite molecular model was constructed based on experimental results of multiple techniques, which was then adjusted by concentrations of covalent bonds.
Unravelling diversity and metabolic potential of microbial consortia at each stage of leather sewage treatment
Authors: Liang Hebin , Ye Dongdong , Luo Lixin
Published: August 2017

Activated sludge is essential for the biological wastewater treatment process and the identification of active microbes enlarges awareness of their ecological functions in this system.
Gas–solid reaction for in situ deposition of Cu3SbS4 on a mesoporous TiO2 film
Authors: Zhang Yu , Tian Jianhua , Jiang Kejian , Huang Jinhua , Wang Huijia , Song Yanlin
Published: August 2017

A novel, facile, in situ gas–solid reaction method has been successfully employed for the deposition of famatinite (Cu3SbS4) semiconductor on a mesosporous TiO2 film. The Cu3SbS4 film shows good photoresponse performance with a high potential as a photovoltaic absorber.
Light filter tailoring – the impact of light emitting diode irradiation on the morphology and optical properties of silver nanoparticles within polyethylenimine thin films
Authors: Kemper F. , Beckert E. , Eberhardt R. , Tünnermann A.
Published: August 2017

In this contributionin situemission filter generation for,e.g.fluorescence light detection by morphology tailoring of silver nanoparticles within a polymer layer, is presented for the first time.
Electrodeposited films to MOF-derived electrochemical energy storage electrodes: a concept of simplified additive-free electrode processing for self-standing, ready-to-use materials
Authors: Linnemann Julia , Taudien Laura , Klose Markus , Giebeler Lars
Published: August 2017

Already electrically contacted metal oxide/carbon materials for supercapacitor electrodes are derived from electrodeposited cobalt– or manganese–organic films on current collectors.
Inorganic layered ion-exchangers for decontamination of toxic metal ions in aquatic systems
Authors: He Wenya , Ai Kelong , Ren Xiaoyan , Wang Shengyan , Lu Lehui
Published: August 2017

Inorganic layered ion-exchangers have received extensive attention in the field of environmental remediation due to their high chemical, thermal and radiolytic stability, large surface areas, and excellent ion exchange capacities.
Free-standing compact cathodes for high volumetric and gravimetric capacity Li–S batteries
Authors: Hu Cheng , Kirk Caroline , Silvestre-Albero Joaquín , Rodríguez-Reinoso Francisco , Biggs Mark James
Published: August 2017

Free-standing compact Li–S cathodes with high volumetric/gravimetric capacities are prepared by embedding highly porous S-loaded carbon nanospheres into dense MWCNT networks.
A correlation between small-molecule dependent nanomorphology and device performance of organic light-emitting diodes with ternary blend emitting layers
Authors: Odongo Ngome Francis Okello , Kim Young-Tae , Lee Hyeon-Dong , Kim Young-Hoon , Lee Tae-Woo , Park Chan-Gyung
Published: August 2017

We successfully control the Ir(ppy)3 needle-like aggregates in small-molecule based emitting layers by solvent mixture for improving the properties of OLEDs.
A pH-responsive assembly based on upconversion nanocrystals and ultrasmall nickel nanoparticles
Authors: Xu Xia , Long Yan , Lei Pengpeng , Dong Lile , Du Kaimin , Feng Jing , Zhang Hongjie
Published: August 2017

A hybrid assembly based on NaYF4:Yb3+,Er3+/Tm3+@NaYF4(core@shell) upconversion nanocrystals and ultrasmall Ni nanoparticles (abbreviated as core@shell@Ni) for rapid response towards pH in different PBS solutions.
Interface effect on electronic and optical properties of antimonene/GaAs van der Waals heterostructures
Authors: Wang Ning , Cao Dan , Wang Jun , Liang Pei , Chen Xiaoshuang , Shu Haibo
Published: August 2017

Antimonene/GaAs van der Waals heterostructures exhibit a type-II band alignment and a high optical absorption coefficient in the visible-light range.
Backstepping‐based boundary feedback control for a fractional reaction diffusion system with mixed or Robin boundary conditions
Authors: Chen Juan , Zhuang Bo , Chen YangQuan , Cui Baotong
Published: August 2017

This study is concerned with a stabilisation problem of a boundary controlled fractional reaction diffusion (FRD) system with mixed or Robin boundary conditions. The contribution of this study is to utilise boundary feedback control to stabilise the FRD system with mixed or Robin boundary conditions in terms of the backstepping method. Specifically, three backstepping‐based boundary feedback controllers have been proposed to address the stabilisation problem of the FRD system with mixed or Robin boundary conditions, including Dirichlet, Neumann, and Robin backstepping‐based boundary feedback controllers. Moreover, based on Lyapunov‐based Mittag–Leffler stability theory, we prove that the FRD system with mixed or Robin boundary conditions is Mittag–Leffler stable by the proposed three backstepping‐based boundary feedback controllers. Finally, the numerical efforts of the open‐loop and the closed‐loop solutions of the FRD systems with mixed or Robin boundary conditions are presented by two numerical experiments to verify the validness of our results.
Single pole‐to‐ground fault location method for MMC‐HVDC system using active pulse
Authors: Bi Tianshu , Wang Shuai , Jia Ke
Published: August 2017

Modular multilevel converter HVDC (MMC‐HVDC) systems have been commissioned in China, America and Europe. With the demand of long‐distance and large‐capacity power transmission, the MMC‐HVDC systems using overhead lines get more attention. When a single pole‐to‐ground permanent fault occurs, the fault current is very small, therefore if the fault location is determined, the fault can be cleared and the HVDC system can revert to normal operation without interruption. MMC‐HVDC can quickly control the work state of sub‐modules (SMs), therefore, it is possible to generate travelling wave pulses propagating to the line by controlling SM, without the need of additional equipment. So in this study, a fault location method for MMC‐HVDC using active pulse is proposed. Meanwhile dichotomising recursion singular value decomposition is used to detect the arrival time of active pulse. The proposed method does not require additional equipment and the method is not influenced by transition resistance. And fault location can be repeated since the pulse can be sent repeatedly. Computer simulations are performed and the results show that the proposed method can locate the grounding point of MMC‐HVDC reliably and with increased accuracy relative to existing methods.
Abductive identification of bad data: methodology and field test
Authors: Sheng Tongtian , Wu Wenchuan , Sun Hongbin , Guo Qinglai , Zhang Boming
Published: August 2017

This study describes a solution to discriminate the original sources of bad data which are concerned by the substation maintainers. Bad data caused by defects of monitoring system, such as mal‐setting of monitoring devices or time skew, are concerned here. These bad data can be identified mostly in electric power control centre by bad data identification (BDI) methods including robust state estimation; however, these methods can hardly explain the relevant original sources of bad data in substations. Here, the authors propose a data‐driven method named abductive identification (AbI) to discriminate the original sources of bad data already identified by BDI methods. In the AbI method, feature patterns of bad data, based on their residuals, are investigated. A feature pattern selection method for bad data is then proposed, in which both the absolute residual and relative residual are considered. Based on this feature selection approach, a Bayesian classifier is developed to identify the original sources of bad data. A two‐level architecture for the AbI approach is introduced to deal with diverse bad data patterns of wide‐area networks. Simulation and field test results demonstrate the applicability of the proposed method.
Palladium-Catalyzed Cross-Coupling of 1,3,4-Oxadiazoles and
Styrenes: An Efficient Method to Synthesize 2-Alkenyl-1,3,4-
Oxadiazoles§
Authors: Salvanna N. , Das Biswanath , Reddy P.
Published: August 2017

2-Alkenyl-1,3,4-oxadiazole derivatives have been prepared by cross-coupling of 1,3,4-oxadiazoles with styrenes by using palladium(II) trifluoroacetate [Pd(TFA)2] as a catalyst, 1,10-phenanthroline as a ligand, silver trifluoroacetate as an oxidant, and toluene as a solvent. The products were formed in high yields and no byproducts were detected.
Influence of Bone Marrow Edema on Medial Unicompartmental Knee Arthroplasty among Patients with Patellofemoral Osteoarthritis
Authors: Yue Jiaji , Ma Xiaojun , Li Yaqiang , Wang Yu , Zhu Yuchang , Cheng Biao , Yang Chunxi
Published: August 2017

This study aims to compare clinical outcomes in unicompartmental knee arthroplasty (UKA) patients with or without magnetic resonance imaging (MRI) evidence of bone marrow edema (BME) in the patella and to evaluate the effect of functional outcomes after UKA in patients with patellofemoral osteoarthritis (PF OA). Outcomes of 146 knees in 141 patients who underwent medial UKA were included. According to their preoperative condition of patellofemoral joints, patients were divided into three groups: Group A, non-PF OA (Kellgren–Lawrence [K–L] scale = 0); group B, PF OA without BME (K–L ≥ 1, bone marrow edema pattern [BMEP] = 0); group C, PF OA with BME (K–L ≥ 1, BMEP ≥ 1). Clinical outcomes including visual analog scale (VAS) scores of knee pain, Hospital for Special Surgery (HSS) scores, and range of motions (ROMs) were evaluated and analyzed at the postoperative follow-up of 3 months and 2 years. From our results, BME was highly correlated to poor outcome in patients with UKA. At follow-up of 3 months, BME influenced the clinical outcome of UKA at an early postoperative stage in terms of VAS scores, HSS scores, and ROMs. At the final follow-up of 2 years, the clinical outcome was improved in terms of HSS score, although the anterior knee pain and active ROMs were still worse than that of patients without BME. In conclusion, there was no significant difference in clinical outcomes in patients without BME regardless of PF OA. However, the condition of BME should be taken serious consideration because of its indication of an adverse effect on the outcome after UKA.
Old Solutions for New Troubles in Complications after Thoracic Endovascular Aortic Repair
Authors: Fortunato German , Stöger Guillermo , Marenchino Ricardo , Kotowicz Vadim
Published: August 2017

Background The authors present two cases with type B aortic dissection initially treated by endovascular stent graft who developed aortic complications posttreatment and required surgical treatment.

Case Description A 50-year-old woman and a 65-year-old man underwent endovascular treatment for thoracic aortic aneurysm associated with type B dissection and —both of them evolved with endoleak type 1. The first case was related to aortobronchial fistula, and the second one was associated with ascending aortic aneurysm. An extra-anatomical ascending aorta-supraceliac aorta bypass grafting was decided due to the persistent leak.

Conclusion Surgery is an excellent choice for complex complications after thoracic endovascular aortic repair with previous failed attempts of endovascular resolution.
Bilder sagen mehr als Worte
Authors: Harms Marlen
Published: August 2017

Die Diabetesbehandlung ist komplex: Blutzucker messen, Insulin spritzen oder das Vermeiden von Hypoglykämien sind Themen, mit denen die Betroffenen nach ihrer Diagnose das erste Mal in Berührung kommen. Dazu kommt die psychologische Belastung, lebenslang an einer chronischen Erkrankung zu leiden. In dieser Situation müssen nicht unbedingt noch Sprachbarrieren oder eine eingeschränkte kognitive Leistungsfähigkeit hinzukommen, damit Schulungsinhalte rund um die Erkrankung und deren Therapie „nicht ankommen“. Individuelle, ganz auf die persönlichen Bedürfnisse eines Betroffenen abgestimmte Sketchnotes können dann helfen, den Patienten die Grundprinzipien der Diabetesbehandlung nahe zu bringen. Schritt für Schritt wird mit kleinen Zeichnungen erklärt, worauf es beim Blutzuckermessen oder bei der Insulininjektion ankommt. Eine Diabetesschulung können Sketchnotes nicht ersetzten, aber sie können den Einstieg in die Diabetesbehandlung sinnvoll unterstützen.
Die Behandlung der laryngealen Dystonie mit
Botulinumtoxin
Authors: Olthoff Arno , Grosheva Maria , Reichel Gerhard , Volk Gerd Fabian , Laskawi Rainer
Published: August 2017

Die Behandlung der laryngealen Dystonie mit Botulinumtoxin ist erfolgreich und
wird von den Kostenträgern übernommen. Eine qualitativ gute Behandlung sollte
jedem Patienten garantiert werden und deshalb ist es wichtig, generelle
Standards im Expertenkreis zu erstellen. In dem hier vorliegenden Artikel werden
verschiedene Aspekte des Krankheitsbildes „Spasmodische Dysphonie“ bzw.
„Laryngeale Dystonie“ von Experten beleuchtet und diskutiert. Hierzu zählen
neuere Erkenntnisse über die Ätiologie, anatomische Besonderheiten, Standards in
der Diagnostik und der Therapie sowie auch Punkte, die noch in der Diskussion
sind.
Sport für das diabetische Gehirn
Authors: Brinkmann Christian
Published: August 2017

Im Rahmen der Projektförderung „Wii are sporting! – Integrative Studie zur Erforschung der Wirksamkeit von Exergaming auf den Glukosestoffwechsel sowie die körperliche und kognitive Leistungsfähigkeit bei älteren Typ-2-Diabetikern“ durch die Deutsche Diabetes Stiftung (DDS) wurde der Einfluss einer Akutbelastung auf neurotrophe Faktoren untersucht, die unter anderem zur Bildung neuer Nervenzellen im Gehirn beitragen können – mit überraschenden Ergebnissen.
Ambulante Versorgung von Geflüchteten durch Tropenmediziner
Authors: Höcker Jenny , Fischer Florian , Krämer Alexander , Prüfer-Krämer Luise
Published: August 2017

Niedergelassene Tropenmediziner beteiligen sich im Praxisalltag unter anderem mit der medizinischen Versorgung von Geflüchteten. Um die Chancen und Herausforderungen dieser Tätigkeit aufzuarbeiten, wurden 8 leidfadengestützte qualitative Experteninterviews im Zeitraum von Januar bis März 2016 mit niedergelassenen Tropenmedizinern geführt. Es zeigte sich, dass die Geflüchteten vornehmlich hausärztlich zu behandelnde Erkrankungen (z.B. Infektionen des oberen Respirationstrakts oder Magen- und Darminfekte) aufweisen, es kommen jedoch auch seltene Infektionen und Tropenkrankheiten vor. Schwierigkeiten stellen vor allem sprachliche und kulturelle Barrieren dar. Die Einführung der elektronischen Gesundheitskarte wird als wünschenswert angesehen, um bürokratische Hürden zu verringern. Wichtig ist zudem die Förderung einer engeren Zusammenarbeit zwischen Tropenmedizinern und Hausärzten.
Numerical study of the wave-break in the vacuum-plasma interface during the interaction of an intense laser pulse
Authors: Chakhmachi Amir , Khalilzadeh Elnaz , Pishdast Masoud , Yazdanpanah Jamalaldin
Published: August 2017

In this paper, the wave break in the plasma-vacuum interface during the intense laser interaction is investigated. Since the nonlinear wave breaking is a non-adiabatic process, the fully kinetic 1D-3V Particle-In-Cell (PIC) simulation experiments are performed to identify whether that the origin of this mechanism is electromagnetic or electrostatic. Our simulation results show that the nonlinear wave breaking on the vacuum-plasma interface has electrostatic origin. In addition, it is found that for pulse lengths exceeding the plasma wavelength this electrostatic phenomenon comes in conjunction with some active electromagnetic effects having the same impact on the electron acceleration. In these regards, we conduct sophisticated simulations isolating these electromagnetic effects and study the effects of the pulse parameters such as the pulse rise time, pulse length, and pulse shape on the boundary nonlinear wave breaking. The study of the pulse rise-time variation effects shows that as the rise time of the laser pulse decreases, the number of the electrons involved in the nonlinear wave breaking, maximum energy of the trapped electrons and the path length of the accelerated electrons in the phase space are increased. Also, the study of phase space and field patterns in our simulation indicates that the reduction of the pulse flat top duration time causes that the smaller part of the electrons and the smaller portion of the wake wave involve in the nonlinear wave breaking.
32-channel time-correlated-single-photon-counting system for high-throughput lifetime imaging
Authors: Peronio P. , Labanca I. , Acconcia G. , Ruggeri A. , Lavdas A. A. , Hicks A. A. , Pramstaller P. P. , Ghioni M. , Rech I.
Published: August 2017

Time-Correlated Single Photon Counting (TCSPC) is a very efficient technique for measuring weak and fast optical signals, but it is mainly limited by the relatively “long” measurement time. Multichannel systems have been developed in recent years aiming to overcome this limitation by managing several detectors or TCSPC devices in parallel. Nevertheless, if we look at state-of-the-art systems, there is still a strong trade-off between the parallelism level and performance: the higher the number of channels, the poorer the performance. In 2013, we presented a complete and compact 32 × 1 TCSPC system, composed of an array of 32 single-photon avalanche diodes connected to 32 time-to-amplitude converters, which showed that it was possible to overcome the existing trade-off. In this paper, we present an evolution of the previous work that is conceived for high-throughput fluorescence lifetime imaging microscopy. This application can be addressed by the new system thanks to a centralized logic, fast data management and an interface to a microscope. The new conceived hardware structure is presented, as well as the firmware developed to manage the operation of the module. Finally, preliminary results, obtained from the practical application of the technology, are shown to validate the developed system.
Higher-derivative generalization of conformal mechanics
Authors: Baranovsky Oleg
Published: August 2017

Higher-derivative analogs of multidimensional conformal particle and many-body conformal mechanics are constructed. Their Newton-Hooke counterparts are derived by applying appropriate coordinate transformations.
Uncovering low dimensional macroscopic chaotic dynamics of large finite size complex systems
Authors: Skardal Per Sebastian , Restrepo Juan G. , Ott Edward
Published: August 2017

In the last decade, it has been shown that a large class of phase oscillator models admit low dimensional descriptions for the macroscopic system dynamics in the limit of an infinite number N of oscillators. The question of whether the macroscopic dynamics of other similar systems also have a low dimensional description in the infinite N limit has, however, remained elusive. In this paper, we show how techniques originally designed to analyze noisy experimental chaotic time series can be used to identify effective low dimensional macroscopic descriptions from simulations with a finite number of elements. We illustrate and verify the effectiveness of our approach by applying it to the dynamics of an ensemble of globally coupled Landau-Stuart oscillators for which we demonstrate low dimensional macroscopic chaotic behavior with an effective 4-dimensional description. By using this description, we show that one can calculate dynamical invariants such as Lyapunov exponents and attractor dimensions. One could also use the reconstruction to generate short-term predictions of the macroscopic dynamics.
Plasmonic amplification of terahertz radiation in a periodic graphene structure with the carrier injection
Authors: Polischuk Olga V. , Fateev Denis V. , Otsuji Taiichi , Popov Vyacheslav V.
Published: August 2017

Injection pumping of the pristine graphene is a promising alternative to optical pumping, but it is not obvious how to properly combine electronic and plasmonic features in one and the same device in order to obtain the terahertz plasmon amplification in graphene with injection pumping. This paper shows that an amplified plasmon mode can be effectively excited at the plasmon resonance frequencies in an active ungated region graphene with injecting (absorbing) gated parts of the periodic graphene structure. Necessary conditions for the plasmon lasing in the structure are found.
Spin diffusion length of Permalloy using spin absorption in lateral spin valves
Authors: Sagasta Edurne , Omori Yasutomo , Isasa Miren , Otani YoshiChika , Hueso Luis E. , Casanova Fèlix
Published: August 2017

We employ the spin absorption technique in lateral spin valves to extract the spin diffusion length of Permalloy (Py) as a function of temperature and resistivity. A linear dependence of the spin diffusion length with the conductivity of Py is observed, evidencing that the Elliott-Yafet mechanism is the dominant spin relaxation mechanism in Permalloy. Completing the dataset with additional data found in the literature, we obtain λPy = (0.91 ± 0.04) (fΩm2)/ρPy.
Effect of self-heating on electrical characteristics of AlGaN/ GaN HEMT on Si (111) substrate
Authors: Nigam Adarsh , Bhat Thirumaleshwara N. , Rajamani Saravanan , Dolmanan Surani Bin , Tripathy Sudhiranjan , Kumar Mahesh
Published: August 2017

In order to study the effect of self-heating of AlGaN/ GaN high electron mobility transistors (HEMTs) characteristics fabricated on Si(111) substrate, simulations of 2DEG temperature on different drain voltages have been carried out by Sentaurus TCAD simulator tool. Prior to the electrical direct-current (DC) characteristics studies, structural properties of the HEMT structures were examined by scanning transmission electron microscopy. The comparative analysis of simulation and experimental data provided sheet carrier concentration, mobility, surface traps, electron density at 2DEG by considering factors such as high field saturation, tunneling and recombination models. Mobility, surface trap concentration and contact resistance were obtained by TCAD simulation and found out to be ∼1270cm2/Vs, ∼2×1013 cm-2 and ∼0.2 Ω.mm, respectively, which are in agreement with the experimental results. Consequently, simulated current-voltage characteristics of HEMTs are in good agreement with experimental results. The present simulator tool can be used to design new device structures for III-nitride technology.
100-period InGaAsP/InGaP superlattice solar cell with sub-bandgap quantum efficiency approaching 80%
Authors: Sayed Islam E. H. , Jain Nikhil , Steiner Myles A. , Geisz John F. , Bedair S. M.
Published: August 2017

InGaAsP/InGaP quantum well (QW) structures are promising materials for next generation photovoltaic devices because of their tunable bandgap (1.50–1.80 eV) and being aluminum-free. However, the strain-balance limitations have previously limited light absorption in the QW region and constrained the external quantum efficiency (EQE) values beyond the In0.49Ga0.51P band-edge to less than 25%. In this work, we show that implementing a hundred period lattice matched InGaAsP/InGaP superlattice solar cell with more than 65% absorbing InGaAsP well resulted in more than 2× improvement in EQE values than previously reported strain balanced approaches. In addition, processing the devices with a rear optical reflector resulted in strong Fabry-Perot resonance oscillations and the EQE values were highly improved in the vicinity of these peaks, resulting in a short circuit current improvement of 10% relative to devices with a rear optical filter. These enhancements have resulted in an InGaAsP/InGaP superlattice solar cell with improved peak sub-bandgap EQE values exceeding 75% at 700 nm, an improvement in the short circuit current of 26% relative to standard InGaP devices, and an enhanced bandgap-voltage offset (Woc) of 0.4 V.
The application of axisymmetric lattice Boltzmann two-phase model on simulations of liquid film dewetting
Authors: Wang Lei , Sun Jianglong
Published: August 2017

An axisymmetric two-phase lattice Boltzmann method is applied to simulate the dewetting dynamics of a thin liquid film on a substrate. Initially, a circular dry spot exists in the center of the liquid film. A contact line forms around the dry spot and expands outwards. The liquid films dewetting on smooth and rough substrates are investigated. For a smooth substrate, the effects of the contact angle (θeq), Ohnesorge number (Oh), and viscosity ratio (λμ) are studied. It is observed that the contact line recedes with a constant velocity V and that if θeq > 45°, V has a linear relationship with θeq, which has never been mentioned in previous literatures. For a rough substrate, well-distributed pillars are set up to represent the roughness. There are two states for the liquid film dewetting on a rough substrate: Cassie and Wenzel states. By comparison, it is found that the speed of the liquid film dewetting on the rough substrate of the Cassie state is slightly faster than that on the smooth substrate but much faster than that on the rough substrate of the Wenzel state, i.e., Wenzel state can obviously hold back the movement of the receding contact line. The corresponding mechanism is analyzed. The effect of the geometric factors of the pillars on the dewetting speed is discussed in detail. It is indicated that both the width and the depth of the grooves in roughness can significantly affect the dewetting speed. The results are helpful to design structured substrates for controlling the dewetting process of the liquid film.
Real-time microwave sensor system for detection of polluting substances in pure water
Authors: Neves A. L. , Georget E. , Cochinaire N. , Sabouroux P.
Published: August 2017

In the present work, a real-time coaxial sensor for detecting foreign substances in aqueous solutions was developed and tested. This tool, based on a coaxial propagation line for determining the electromagnetic parameters of materials, was updated into a liquid permittivity monitoring sensor of continuous flow. A few solutions of different nature were tested, and while adding a liquid or electrolyte substance, named “pollutant,” variations in the base solution were documented. Ethanol and water mixtures were used as reference, while the ability of the system to detect emulsions (such as oil in water solutions) was also evaluated. The system shows great potential for the quantification and qualification of liquid mixtures, having a threshold of reduced volume/volume fractions of foreign substances or pollutants, a property which is shown to be extremely useful in an analogue of high glycaemia (diabetes disease)—thus, opening the possibilities of monitoring biological liquids.
Design and implementation of improved LsCpLp resonant circuit for power supply for high-power electromagnetic acoustic transducer excitation
Authors: Zao Yongming , Ouyang Qi , Chen Jiawei , Zhang Xinglan , Hou Shuaicheng
Published: August 2017

This paper investigates the design and implementation of an improved series-parallel inductor-capacitor-inductor (LsCpLp) resonant circuit power supply for excitation of electromagnetic acoustic transducers (EMATs). The main advantage of the proposed resonant circuit is the absence of a high-permeability dynamic transformer. A high-frequency pulsating voltage gain can be achieved through a double resonance phenomenon. Both resonant tailing behavior and higher harmonics are suppressed by the improved resonant circuit, which also contributes to the generation of ultrasonic waves. Additionally, the proposed circuit can realize impedance matching and can also optimize the transduction efficiency. The complete design and implementation procedure for the power supply is described and has been validated by implementation of the proposed power supply to drive a portable EMAT. The circuit simulation results show close agreement with the experimental results and thus confirm the validity of the proposed topology. The proposed circuit is suitable for use as a portable EMAT excitation power supply that is fed by a low-voltage source.
Alternans promotion in cardiac electrophysiology models by delay differential equations
Authors: Gomes Johnny M. , dos Santos Rodrigo Weber , Cherry Elizabeth M.
Published: August 2017

Cardiac electrical alternans is a state of alternation between long and short action potentials and is frequently associated with harmful cardiac conditions. Different dynamic mechanisms can give rise to alternans; however, many cardiac models based on ordinary differential equations are not able to reproduce this phenomenon. A previous study showed that alternans can be induced by the introduction of delay differential equations (DDEs) in the formulations of the ion channel gating variables of a canine myocyte model. The present work demonstrates that this technique is not model-specific by successfully promoting alternans using DDEs for five cardiac electrophysiology models that describe different types of myocytes, with varying degrees of complexity. By analyzing results across the different models, we observe two potential requirements for alternans promotion via DDEs for ionic gates: (i) the gate must have a significant influence on the action potential duration and (ii) a delay must significantly impair the gate's recovery between consecutive action potentials.
Nonlinear diffusion and thermo-electric coupling in a two-variable model of cardiac action potential
Authors: Gizzi A. , Loppini A. , Ruiz-Baier R. , Ippolito A. , Camassa A. , La Camera A. , Emmi E. , Di Perna L. , Garofalo V. , Cherubini C. , Filippi S.
Published: August 2017

This work reports the results of the theoretical investigation of nonlinear dynamics and spiral wave breakup in a generalized two-variable model of cardiac action potential accounting for thermo-electric coupling and diffusion nonlinearities. As customary in excitable media, the common Q10 and Moore factors are used to describe thermo-electric feedback in a 10° range. Motivated by the porous nature of the cardiac tissue, in this study we also propose a nonlinear Fickian flux formulated by Taylor expanding the voltage dependent diffusion coefficient up to quadratic terms. A fine tuning of the diffusive parameters is performed a priori to match the conduction velocity of the equivalent cable model. The resulting combined effects are then studied by numerically simulating different stimulation protocols on a one-dimensional cable. Model features are compared in terms of action potential morphology, restitution curves, frequency spectra, and spatio-temporal phase differences. Two-dimensional long-run simulations are finally performed to characterize spiral breakup during sustained fibrillation at different thermal states. Temperature and nonlinear diffusion effects are found to impact the repolarization phase of the action potential wave with non-monotone patterns and to increase the propensity of arrhythmogenesis.
Recommendations and illustrations for the evaluation of photonic random number generators
Authors: Hart Joseph D. , Terashima Yuta , Uchida Atsushi , Baumgartner Gerald B. , Murphy Thomas E. , Roy Rajarshi
Published: August 2017

The never-ending quest to improve the security of digital information combined with recent improvements in hardware technology has caused the field of random number generation to undergo a fundamental shift from relying solely on pseudo-random algorithms to employing optical entropy sources. Despite these significant advances on the hardware side, commonly used statistical measures and evaluation practices remain ill-suited to understand or quantify the optical entropy that underlies physical random number generation. We review the state of the art in the evaluation of optical random number generation and recommend a new paradigm: quantifying entropy generation and understanding the physical limits of the optical sources of randomness. In order to do this, we advocate for the separation of the physical entropy source from deterministic post-processing in the evaluation of random number generators and for the explicit consideration of the impact of the measurement and digitization process on the rate of entropy production. We present the Cohen-Procaccia estimate of the entropy rate h(𝜖,τ) as one way to do this. In order to provide an illustration of our recommendations, we apply the Cohen-Procaccia estimate as well as the entropy estimates from the new NIST draft standards for physical random number generators to evaluate and compare three common optical entropy sources: single photon time-of-arrival detection, chaotic lasers, and amplified spontaneous emission.