bluuebunny/crossref_metadata_2025 huggingface dataset:
Persistent Cognitive Dysfunction in a Non-Hospitalized COVID-19 Long-Hauler Patient Responding to Cognitive Rehabilitation and Citicoline Treatment
Authors: Monastero Roberto , Baschi Roberta
Published: September 2023

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is characterized by severe flu-like symptoms, which can progress to life-threatening systemic inflammation and multiorgan dysfunction. The nervous system is involved in over one-third of patients, and the most common neurological manifestations concern the central nervous system, such as headache, fatigue, and brain fog. The activation of innate, humoral, and cellular immune responses, resulting in a cytokine storm and endothelial and mitochondrial dysfunctions, are the main pathophysiological mechanisms of SARS-CoV-2 infection. Citicoline is an exogenous source of choline and cytidine involved in intracellular phospholipid synthesis, which improves blood flow, brain activity, and mitochondrial dysfunction. This report will present the case of a non-hospitalized, 59-year-old female. After a mild form of SARS-CoV-2 infection, the patient developed cognitive disturbances such as forgetfulness and anomia. The multidimensional neuropsychological assessment revealed an impairment in episodic memory with borderline performance in executive and visuospatial functioning. Cognitive rehabilitation and treatment with citicoline 1000 mg/daily led to a marked improvement in symptoms after six months. Early identification of the neurological sequelae of the Coronavirus Disease 2019 (COVID-19) and timely rehabilitation interventions are required in non-hospitalized long-hauler patients with COVID-19. Long-term treatment with citicoline should be considered as potentially effective in improving cognitive functioning in subjects with Post COVID-19 Neurological Syndrome.
Shrinkage and Consolidation Characteristics of Chitosan-Amended Soft Soil—A Sustainable Alternate Landfill Liner Material
Authors: Rasheed Romana Mariyam , Moghal Arif Ali Baig , Jannepally Sai Sampreeth Reddy , Rehman Ateekh Ur , Chittoori Bhaskar C. S.
Published: September 2023

Kuttanad is a region that lies in the southwest part of Kerala, India, and possesses soft soil, which imposes constraints on many civil engineering applications owing to low shear strength and high compressibility. Chemical stabilizers such as cement and lime have been extensively utilized in the past to address compressibility issues. However, future civilizations will be extremely dependent on the development of sustainable materials and practices such as the use of bio-enzymes, calcite precipitation methods, and biological materials as a result of escalating environmental concerns due to carbon emissions of conventional stabilizers. One such alternative is the utilization of biopolymers. The current study investigates the effect of chitosan (biopolymer extracted from shrimp shells) in improving the consolidation and shrinkage characteristics of these soft soils. The dosages adopted are 0.5%, 1%, 2%, and 4%. One-dimensional fixed ring consolidation tests indicate that consolidation characteristics are improved upon the addition of chitosan up to an optimum dosage of 2%. The coefficient of consolidation increases up to seven times that of untreated soil, indicating the acceleration of the consolidation process by incorporating chitosan. The shrinkage potential is reduced by 11% after amendment with 4% chitosan and all the treated samples exhibit zero signs of curling. Based on the findings from consolidation and shrinkage data, carbon emission assessments are carried out for a typical landfill liner amended with an optimum dosage of chitosan. In comparison to conventional stabilizers like cement and lime, the results indicate that chitosan minimized carbon emissions by 7.325 times and 8.754 times, respectively.
Outcome of Second Primary Malignancies Developing in Multiple Myeloma Patients
Authors: Avivi Irit , Vesole David H. , Davila-Valls Julio , Usnarska-Zubkiewicz Lidia , Olszewska-Szopa Magdalena , Milunovic Vibor , Baumert Bartłomiej , Osękowska Bogumiła , Kopińska Anna , Gentile Massimo , Puertas-Martinez Borja , Robak Paweł , Crusoe Edvan , Rodriguez-Lobato Luis Gerardo , Gajewska Małgorzata , Varga Gergely , Delforge Michel , Cohen Yael , Gozzetti Alessandro , Pena Camila , Shustik Chaim , Mikala Gabor , Zalac Klara , Alexander H. Denis , Barth Peter , Weisel Katja , Martínez-López Joaquín , Waszczuk-Gajda Anna , Krzystański Mateusz , Jurczyszyn Artur
Published: September 2023

Background: There is an increased risk of second primary malignancies (SMPs) in patients with multiple myeloma (MM). This multinational ‘real-world’ retrospective study analyzed the characteristics and outcomes of MM patients that developed SPMs. Results: 165 patients were analyzed: 62.4% males; 8.5% with a prior cancer; 113 with solid SPMs, mainly ≥stage 2; and 52 with hematological SPM (hemato-SPM), mainly MDS/AML. Patients with hemato-SPM were younger (p = 0.05) and more frequently had a prior AutoHCT (p = 0.012). The time to SPM was shorter in the older (>65 years) and more heavily pretreated patients. One hundred patients were actively treated at the time of SPM detection. Treatment was discontinued in 52, substituted with another anti-MM therapy in 15, and continued in 33 patients. Treatment discontinuation was predominant in the patients diagnosed with hemato-SPM (76%). The median OS following SPM detection was 8.5 months, and the main cause of death was SPM. A poor ECOG status predicted a shorter OS (PS 3 vs. 0, HR = 5.74, 2.32–14.21, p < 0.001), whereas a normal hemoglobin level (HR = 0.43, 0.19–0.95, p = 0.037) predicted longer OS. Conclusions: With the continuing improvement in OS, a higher proportion of MM patients might develop SPM. The OS following SPM diagnosis is poor; hence, frequent surveillance and early detection are imperative to improve outcomes.
Comparing Liver Venous Deprivation and Portal Vein Embolization for Perihilar Cholangiocarcinoma: Is It Time to Shift the Focus to Hepatic Functional Reserve Rather than Hypertrophy?
Authors: Marino Rebecca , Ratti Francesca , Della Corte Angelo , Santangelo Domenico , Clocchiatti Lucrezia , Canevari Carla , Magnani Patrizia , Pedica Federica , Casadei-Gardini Andrea , De Cobelli Francesco , Aldrighetti Luca
Published: September 2023

Purpose: Among liver hypertrophy technics, liver venous deprivation (LVD) has been recently introduced as an effective procedure to combine simultaneous portal inflow and hepatic outflow abrogation, raising growing clinical interest. The aim of this study is to investigate the role of LVD for preoperative optimization of future liver remnant (FLR) in perihilar cholangiocarcinoma (PHC), especially when compared with portal vein embolization (PVE). Methods: Between January 2013 and July 2022, all patients diagnosed with PHC and scheduled for preoperative optimization of FTR, through radiological hypertrophy techniques, prior to liver resection, were included. FTR volumetric assessment was evaluated at two distinct timepoints to track the progression of both early (T1, 10 days post-procedural) and late (T2, 21 days post-procedural) efficacy indicators. Post-procedural outcomes, including functional and volumetric analyses, were compared between the LVD and the PVE cohorts. Results: A total of 12 patients underwent LVD while 19 underwent PVE. No significant differences in either post-procedural or post-operative complications were found. Post-procedural FLR function, calculated with (99m) Tc-Mebrofenin hepatobiliary scintigraphy, and kinetic growth rate, at both timepoints, were greater in the LVD cohort (3.12 ± 0.55%/min/m2 vs. 2.46 ± 0.64%/min/m2, p = 0.041; 27.32 ± 16.86%/week (T1) vs. 15.71 ± 9.82%/week (T1) p < 0.001; 17.19 ± 9.88%/week (T2) vs. 9.89 ± 14.62%/week (T2) p = 0.034) when compared with the PVE cohort. Post-procedural FTR volumes were similar for both hypertrophy techniques. Conclusions: LVD is an effective procedure to effectively optimize FLR before liver resection for PHC. The faster growth rate combined with the improved FLR function, when compared to PVE alone, could maximize surgical outcomes by lowering post-hepatectomy liver failure rates.
Survival Prediction of Patients with Bladder Cancer after Cystectomy Based on Clinical, Radiomics, and Deep-Learning Descriptors
Authors: Sun Di , Hadjiiski Lubomir , Gormley John , Chan Heang-Ping , Caoili Elaine M. , Cohan Richard H. , Alva Ajjai , Gulani Vikas , Zhou Chuan
Published: September 2023

Accurate survival prediction for bladder cancer patients who have undergone radical cystectomy can improve their treatment management. However, the existing predictive models do not take advantage of both clinical and radiological imaging data. This study aimed to fill this gap by developing an approach that leverages the strengths of clinical (C), radiomics (R), and deep-learning (D) descriptors to improve survival prediction. The dataset comprised 163 patients, including clinical, histopathological information, and CT urography scans. The data were divided by patient into training, validation, and test sets. We analyzed the clinical data by a nomogram and the image data by radiomics and deep-learning models. The descriptors were input into a BPNN model for survival prediction. The AUCs on the test set were (C): 0.82 ± 0.06, (R): 0.73 ± 0.07, (D): 0.71 ± 0.07, (CR): 0.86 ± 0.05, (CD): 0.86 ± 0.05, and (CRD): 0.87 ± 0.05. The predictions based on D and CRD descriptors showed a significant difference (p = 0.007). For Kaplan–Meier survival analysis, the deceased and alive groups were stratified successfully by C (p < 0.001) and CRD (p < 0.001), with CRD predicting the alive group more accurately. The results highlight the potential of combining C, R, and D descriptors to accurately predict the survival of bladder cancer patients after cystectomy.
Induction Fluorouracil-Based Chemotherapy and PET-Adapted Consolidation Chemoradiation with Esophagectomy for High-Risk Gastroesophageal Adenocarcinoma
Authors: Sinnamon Andrew J. , Mehta Rutika , Saeed Samir , Lauwers Gregory Y. , Palm Russell F. , Frakes Jessica M. , Hoffe Sarah E. , Baldonado Jobelle J. , Fontaine Jacques P. , Pimiento Jose M.
Published: September 2023

Background: Neoadjuvant chemoradiation with esophagectomy is standard management for locally advanced esophageal adenocarcinoma. Induction chemotherapy with a tailored approach to chemoradiation based on metabolic response to therapy on PET was explored as an alternative strategy in the CALGB 80803 trial. We sought to describe real-world institutional experience implementing this approach outside of a clinical trial. Methods: Patients who were treated with induction fluorouracil-leucovorin-oxaliplatin (FOLFOX) or fluorouracil-leucovorin-oxaliplatin-docetaxel (FLOT) with tailored chemoradiation based on PET response and subsequent esophagectomy were identified from a prospectively maintained database. Primary outcomes were pathologic complete response (pCR) and overall survival (OS) following completion of all therapy. Results: There were 35 patients who completed induction chemotherapy, chemoradiation, and esophagectomy. Thirty-three completed restaging PET following induction chemotherapy with metabolic response seen in 76% (n = 25/33). The pCR rate was 31% (n = 11/35) and the ypN0 rate was 71% (n = 25/35). Among the patients who demonstrated metabolic response to induction FOLFOX/FLOT and subsequently continued fluorouracil-based chemoradiation, the pCR rate was 39% (n = 9/23). The rate of pathologically negative lymph nodes in this group was high (n = 19/23, 83%) with 100% R0 resection rate (n = 23/23). With the median follow-up of 43 months, the median OS was not reached for this group and was significantly longer than the OS for the remainder of the cohort (p = 0.027, p = 0.046 adjusted for clinical stage). Conclusions: Induction FOLFOX/FLOT chemotherapy with evaluation of sensitivity via metabolic response and tailored chemoradiation seems to lead to high pCR and ypN0 rates in high-risk patients with adenocarcinoma of the esophagus and GE junction. This approach in clinical practice seems to recapitulate encouraging results in clinical trials.
Prognostic Significance of Volumetric Parameters Based on FDG PET/CT in Patients with Lung Adenocarcinoma Undergoing Curative Surgery
Authors: Lee Hyunjong , Choi Yoon-La , Kim Hong Kwan , Choi Yong Soo , Kim Hojoong , Ahn Myung-Ju , Pyo Hong Ryul , Choi Joon Young
Published: September 2023

Introduction: FDG PET/CT is a robust imaging modality to diagnose and stratify prognoses for non-small cell lung carcinoma. However, the role of FDG PET/CT in operable lung adenocarcinoma patients has not been previously investigated in a large cohort with varying pathological stages. The prognostic value of volumetric parameters based on FDG PET/CT was investigated in patients with stage I–III lung adenocarcinoma receiving curative surgery. Methods: This retrospective study included 432 patients with lung adenocarcinoma undergoing preoperative FDG PET/CT between January 2016 and December 2017. Clinicopathologic variables, conventional image parameters, such as the maximum standardized uptake value (SUVmax) and mean SUV (SUVmean) of the primary tumor, and volumetric parameters, such as metabolic tumor volume (MTV) and total lesion glycolysis (TLG), were included in Cox regression analysis. Subgroup analysis was conducted to compare hazard ratios (HRs) based on MTV in each pathological stage. A new staging system including volumetric parameters was suggested. Results: A total of 432 patients (median age: 62 years; interquartile range: 56–70 years; 225 males) were evaluated. Sex, age, presence of EGFR mutation, pathological stage, MTV, and TLG of the primary tumor were selected as statistically significant prognostic factors for overall survival irrespective of other variables (OS; p < 0.05 for all). Pathological stage, MTV, and TLG of the primary tumor were selected as statistically significant prognostic factors for disease-free survival irrespective of other variables (p < 0.05 for all). The suggested new staging system including MTV as an additional criterion showed better discrimination and prediction for OS than the conventional pathological staging system despite statistical insignificance (concordance index: 0.698 vs. 0.673). Conclusions: The volumetric parameters of the primary tumor based on preoperative FDG PET/CT were independent prognostic factors in addition to pathological stage in patients with operable lung adenocarcinoma. The suggested new staging system considering MTV predicted the prognoses better than the conventional pathological staging system.
Real-World Results of Stereotactic Body Radiotherapy for 399 Medically Operable Patients with Stage I Histology-Proven Non-Small Cell Lung Cancer
Authors: Onishi Hiroshi , Shioyama Yoshiyuki , Matsumoto Yasuo , Matsuo Yukinori , Miyakawa Akifumi , Yamashita Hideomi , Matsushita Haruo , Aoki Masahiko , Nihei Keiji , Kimura Tomoki , Ishiyama Hiromichi , Murakami Naoya , Nakata Kensei , Takeda Atsuya , Uno Takashi , Nomiya Takuma , Taguchi Hiroshi , Seo Yuji , Komiyama Takafumi , Marino Kan , Aoki Shinichi , Matsuda Masaki , Akita Tomoko , Saito Masahide
Published: September 2023

Surgery is the standard treatment for stage I non-small cell lung cancer (NSCLC); however, no clear randomized trial demonstrates its superiority to stereotactic body radiotherapy (SBRT) regarding survival. We aimed to retrospectively evaluate the treatment outcomes of SBRT in operable patients with stage I NSCLC using a large Japanese multi-institutional database to show real-world outcome. Exactly 399 patients (median age 75 years; 262 males and 137 females) with stage I (IA 292, IB 107) histologically proven NSCLC (adenocarcinoma 267, squamous cell carcinoma 96, others 36) treated at 20 institutions were reviewed. SBRT was prescribed at a total dose of 48–70 Gy in 4–10 fractions. The median follow-up period was 38 months. Local progression-free survival rates were 84.2% in all patients and 86.1% in the T1, 78.6% in T2, 89.2% in adenocarcinoma, and 70.5% in squamous cell subgroups. Overall 3-year survival rates were 77.0% in all patients: 90.7% in females, 69.6% in males, and 41.2% in patients with pulmonary interstitial changes. Fatal radiation pneumonitis was observed in two patients, all of whom had pulmonary interstitial changes. This real-world evidence will be useful in shared decision-making for optimal treatment, including SBRT for operable stage I NSCLC, particularly in older patients.
Catalysts for Air Pollution Control: Present and Future
Authors: Bortolozzi Juan Pablo , Banús Ezequiel David , Miró Eduardo
Published: September 2023

Due to the continuous increase in both industrial activities and in the use of internal combustion engines, the quality of atmospheric air has progressively deteriorated, both in urban conglomerates and globally [...]
Attenuation of Oxidative Damage via Upregulating Nrf2/HO-1 Signaling Pathway by Protease SH21 with Exerting Anti-Inflammatory and Anticancer Properties In Vitro
Authors: Tarek Hasan , Cho Seung Sik , Hossain Md. Selim , Yoo Jin Cheol
Published: September 2023

Oxidative damage and inflammation are among the very significant aspects interrelated with cancer and other degenerative diseases. In this study, we investigated the biological activities of a 25 kDa protease (SH21) that was purified from Bacillus siamensis. SH21 exhibited very powerful antioxidant and reactive oxygen species (ROS) generation inhibition activity in a dose-dependent approach. The mRNA and protein levels of antioxidant enzymes such as superoxide dismutase 1 (SOD1), catalase (CAT), and glutathione peroxidase 1 (GPx-1) were enhanced in the SH21-treated sample. SH21 also increased the transcriptional and translational activities of NF-E2-related factor 2 (Nrf2) with the subsequent development of detoxifying enzyme heme oxygenase-1 (HO-1). In addition, SH21 showed potential anti-inflammatory activity via inhibition of nitric oxide (NO) and proinflammatory cytokines, such as TNF-α, IL-6, and IL-1β, production in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. At concentrations of 60, 80, and 100 μg/mL, SH21 potentially suppressed nitric oxide synthase (iNOS) and cytokine gene expressions. Furthermore, SH21 significantly released lactate dehydrogenase (LDH) enzyme in cancer cell supernatant in a concentration-dependent manner and showed strong activity against three tested cancer cell lines, including HL-60, A549, and Hela. Our results suggest that SH21 has effective antioxidant, anti-inflammatory, and anticancer effects and could be an excellent therapeutic agent against inflammation-related diseases.
Antioxidant Determining Using Electrochemical Method
Authors: Sukma Rani Melati , Iswantini Dyah , Nurhidayat Novik , Rafi Mohamad , Ariyanti Dita
Published: September 2023

Antioxidants are very beneficial for health as they protect the body from the effects of free radicals on various degenerative diseases caused by food contamination, air pollution, sunlight, etc. In general, methods for measuring the capacity of antioxidants generally use accurate methods such as spectrophotometry and chromatography. Still, this takes time, accurate sample preparation, and must be performed in a laboratory with particular expertise. Therefore, a new, more practical method needs to be developed for determining antioxidants, namely the electrochemical method. The electrochemical method is a promising method to develop because it comes with several advantages, including high sensitivity and fast response. The electrochemical method discussed in this article reviews sensors, biosensors, and nanosensors. This paper comprehensively analyzes contemporary developments in electrochemical biosensor techniques and antioxidant evaluation methodologies. The discussion centers on utilizing multiple biosensors. Electrochemical biosensors have been determined to be prevalent in analyzing food quality, assessing active factor functionality, and screening practical components. The present study outlines the difficulties linked with electrochemical bio-sensor technology and provides insights into the potential avenues for future research in this domain.
Utilising Portable Laser-Induced Breakdown Spectroscopy for Quantitative Inorganic Water Testing
Authors: Schlatter Nils , Lottermoser Bernd G. , Illgner Simon , Schmidt Stefanie
Published: September 2023

At present, the majority of water testing is carried out in the laboratory, and portable field methods for the quantification of elements in natural waters remain to be established. In contrast, portable instruments like portable X-ray fluorescence (pXRF) analysis and portable laser-induced breakdown spectroscopy (pLIBS) have become routine analytical methods for the quantification of elements in solids. This study aims to show that pLIBS can also be used for chemical compositional measurements of natural waters. Bottled mineral waters were selected as sample materials. A surface-enhanced liquid-to-solid conversion technique was used to improve the detection limits and circumvent the physical limitations in liquid analysis. The results show that low to medium mineralised waters can be analysed quantitatively for their ions using the documented method. For more highly concentrated samples, typically above an electrical conductivity (EC) of 1000 µS/cm, further adjustment is required in the form of self-absorption correction. However, water with a conductivity up to this limit can be analysed for the main cations (Li+, Na+, Mg2+, K+, Ca2+, and Sr2+) as well as the main anions (SO42− and Cl−) using the documented method. This study demonstrates that there is significant potential for developing field-based pLIBS as a tool for quantitative water analysis.
Training Packages and Patient Management Tools for Healthcare Staff Working with Small, Nutritionally At-Risk Infants Aged under 6 Months: A Mixed-Methods Study
Authors: Engler Ramona , McGrath Marie , Kerac Marko
Published: September 2023

Skilled staff are essential for successfully managing child malnutrition, especially when dealing with small, nutritionally at-risk infants aged under 6 months. Training and patient management tools provide healthcare workers with core knowledge, skills, and support. To inform more effective future approaches and support the rollout of new WHO wasting prevention/treatment guidelines, we aimed to map and understand globally available training and patient management tools. In a mixed-methods study, we searched the literature to identify different training packages and management tools and conducted semi-structured key informant interviews with staff working in a variety of internationally organizations and settings. Data were analyzed using a phenomenological approach. We found 14 different training packages targeting different settings, including inpatient, outpatient, and humanitarian contexts. Curricula varied, especially around breastfeeding and maternal assessment, mental health, and nutritional status. Key informants (n = 9) reported gaps regarding counseling skills, time for practice, and how to effectively provide mental health counseling. Training delivery was highly dependent on resources and setting. In conclusion, future training should consider setting-specific needs, opportunities, and limitations. Emphasis on breastfeeding-support skills, mental health support, and counseling skills is needed. Enhanced practical sessions, refresher trainings, and ongoing monitoring and support are vital to ensure sustained high-quality services.
Prokaryotic Expression, Purification, and Antibacterial Activity of the Hepcidin Peptide of Crescent Sweetlips (Plectorhinchus cinctus)
Authors: Wang Peixin , Lin Zhongjing , Lin Shaoling , Zheng Baodong , Zhang Yi , Hu Jiamiao
Published: September 2023

The hepcidin peptide of crescent sweetlips (Plectorhinchus cinctus) is a cysteine-rich, cationic antimicrobial peptide that plays a crucial role in the innate immune system’s defense against invading microbes. The aim of this study was to identify the optimal parameters for prokaryotic expression and purification of this hepcidin peptide and characterize its antibacterial activity. The recombinant hepcidin peptides were expressed in Escherichia coli strain Arctic Express (DE3), with culture and induction conditions optimized using response surface methodology (RSM). The obtained hepcidin peptides were then purified before tag cleavage, and their antibacterial activity was determined. The obtained results revealed that induction temperature had the most significant impact on the production of soluble recombinant peptides. The optimum induction conditions were determined to be an isopropylthio-β-galactoside (IPTG) concentration of 0.21 mmol/L, induction temperature of 18.81 °C, and an induction time of 16.01 h. Subsequently, the recombinant hepcidin peptide was successfully purified using Ni-IDA affinity chromatography followed by SUMO protease cleavage. The obtained hepcidin peptide (without His-SUMO tag) demonstrated strong antimicrobial activity in vitro against V. parahaemolyticus, E. coli, and S. aureus. The results showed prokaryotic (E. coli) expression is a feasible way to produce the hepcidin peptide of crescent sweetlips in a cost-effective way, which has great potential to be used as an antimicrobial agent in aquaculture.
Kinetic Study of the Aging and Overaging of Alloy Pb0.058%Ca0.12%Sr1.09%Sn for Battery Grids
Authors: Ait Yassine Youssef , Lakhal Marwan , Labchir Nabil , Zantalla Elhassan , Saad Elmadani , Sannad Mohamed
Published: September 2023

In this paper, we examine the effect of a small amount of Sn, Sr and Ca on the hardening and the kinetic properties of Pb. Experimentally, we analyze the specific process from the structural hardening evolution to equilibrium of PbCaSrSn alloy occurring in two steps. In the first one, a discontinuous transformation hardening and a continuous precipitation take place. A lamellar discontinuous precipitation that occurs after aging, characterizes the second step. Theoretically, we study the aging and overaging kinetics of the alloy by using the two complimentary methods needed to calculate the apparent activation energies of the Pb0.058%Ca0.12%Sr1.09%Sn associated with the various transformations, characterizing its hardening at 20 and 80 °C. We show that activation energies of aging and overaging of Pb0.058%Ca0.12%Sr1.09%Sn alloy are 25 and 28 kJ/mole, respectively, which are four times lower than the self-diffusion energy of Pb. Moreover, the addition of Ca, Sr and Sn leads to an amplification of the maximum hardness from 5 ± 5% HV to 21 ± 5% HV and an acceleration of the transformation hardening process responsible for aging.
Properties of Ni-B/B Composite Coatings Produced by Chemical Reduction
Authors: Gajewska-Midziałek Anna , Cieślak Grzegorz , Gostomska Marta , Ciciszwili Tinatin , Skroban Katarzyna , Dąbrowski Adrian , Pęśko Edyta , Wojda Edyta , Głowacki Michał , Kapuścińska Anna , Trzaska Maria
Published: September 2023

The paper presents the results of research on composite Ni-B coatings with embedded particles of boron produced by a chemical reduction method and their influence on the mechanical, tribological, and corrosion properties of produced materials. Boron was used in two forms: an alloy component and nanoparticles incorporated into the Ni-B matrix. The coatings were deposited from a bath at different concentrations of dispersion phase. The paper also presents the characteristics of the used boron particles. Results of morphology and surface topography (SEM) as well as the structure (XRD) of the produced coatings are presented. The mechanical properties of the produced coatings, like Knoop hardness, Martens hardness, and indentation hardness, as well as the modulus of elasticity, were determined. The tribological tests were carried out using the ball-on-disc method. Electrochemical corrosion tests were conducted by the potentiodynamic method. The adhesion of the coatings to the substrate was evaluated by the scratch test method. Consequently, this investigation yielded a novel material in the form of Ni-B/B composite coatings, exhibiting significantly improved mechanical and tribological properties compared to Ni-B coatings without embedded particles of the dispersion phase.
Resistance of Graphene/Epoxy Resin—Based Composite Materials to γ Radiation Damage and Their Mechanical Properties
Authors: Wang Hongxia , Pei Xiaoyuan , Shao Ruiqi , Liu Shengkai , Wang Wei , Zhao Cun , Xu Zhiwei
Published: September 2023

This study aims to explore the role of graphene in enhancing the radiation resistance of epoxy resin (EP) composites. Through the resin transfer molding process, we prepared 0.3 wt% graphene oxide (GO) and Hummer’s method reduced graphene oxide (Hh-RGO) reinforced EP composites, respectively. By comparing the microstructure, free radical content, thermal stability, and mechanical properties of EP, GO/EP, and Hh-RGO/EP composites before and after γ-ray irradiation, we found that GO and Hh-RGO can effectively reduce the generation of free radicals in EP during irradiation, thereby reducing chemical bond breakage and enhancing its radiation resistance. Particularly, GO demonstrated stronger radiation damage resistance. The results showed that after γ-ray irradiation, the glass transition temperature, nano-indentation depth, and hardness of GO/EP composites decreased by 20.32%, 416.3 nm, and 16.00%, respectively, whereas EP decreased by 30.34%, 502.1 nm, and 41.82% respectively. This is mainly attributed to the fact that the addition of graphene nanoparticles as a reinforcement reduces the free radical content in EP and reduces the damage of free radicals to the EP crosslinked network during irradiation, thereby improving the thermal stability and mechanical properties of the composites. In addition, the Π electrons formed by the hexagonal honeycomb structure of GO and the Π-Π stacking effect formed with free radicals can slow down the aging of epoxy resin in a high-energy radiation environment, thereby prolonging its service life. This study provides important references for further optimization and application of graphene-modified epoxy resin.
Perspectives of Cancer Survivors with Low Income: A Content Analysis Exploring Concerns, Positive Experiences, and Suggestions for Improvement in Survivorship Care
Authors: Nicoll Irene , Lockwood Gina , Fitch Margaret I.
Published: September 2023

The number of cancer survivors in Canada has reached 1.5 million and is expected to grow. It is important to understand cancer survivors’ perspectives about the challenges they face after treatment is completed. Many factors create barriers to accessing assistance, and limited income may be a significant one. This study is a secondary analysis of data from a publicly available databank (Cancer Survivor Transitions Study) regarding the experiences of Canadian cancer survivors. The goal was to explore major challenges, positive experiences, and suggestions for improvement in survivorship care for low-income Canadian cancer survivors one to three years following treatment. A total of 1708 survey respondents indicated a low annual household income (<$25,000 CD). A content analysis was performed utilizing written comments to open-ended questions. The major challenges respondents described focused on physical capacity limits and treatment side effects; positive experiences emphasized support and attentive care; and suggestions for improvements highlighted the need for better support, information about self-care and side effect management, and timely follow-up care. The relationships between household income and the management of survivors’ physical, emotional, and practical concerns require consideration. The design of follow-up care plans, programs, services, and financial assessments of patients may prepare survivors for predictable issues and costs in their transition to survivorship.
Touching Base with Some Mediterranean Diseases of Interest from Paradigmatic Cases at the “Magna Graecia” University Unit of Infectious Diseases: A Didascalic Review
Authors: Lionello Ferdinando Carmelo Pio , Rotundo Salvatore , Bruno Gabriele , Marino Gabriella , Morrone Helen Linda , Fusco Paolo , Costa Chiara , Russo Alessandro , Trecarichi Enrico Maria , Beltrame Anna , Torti Carlo
Published: September 2023

Among infectious diseases, zoonoses are increasing in importance worldwide, especially in the Mediterranean region. We report herein some clinical cases from a third-level hospital in Calabria region (Southern Italy) and provide a narrative review of the most relevant features of these diseases from epidemiological and clinical perspectives. Further, the pathogenic mechanisms involved in zoonotic diseases are reviewed, focusing on the mechanisms used by pathogens to elude the immune system of the host. These topics are of particular concern for individuals with primary or acquired immunodeficiency (e.g., people living with HIV, transplant recipients, patients taking immunosuppressive drugs). From the present review, it appears that diagnostic innovations and the availability of more accurate methods, together with better monitoring of the incidence and prevalence of these infections, are urgently needed to improve interventions for better preparedness and response.
The Diagnostic Accuracy of Artificial Intelligence in Radiological Markers of Normal-Pressure Hydrocephalus (NPH) on Non-Contrast CT Scans of the Brain
Authors: Songsaeng Dittapong , Nava-apisak Poonsuta , Wongsripuemtet Jittsupa , Kingchan Siripra , Angkoondittaphong Phuriwat , Phawaphutanon Phattaranan , Supratak Akara
Published: September 2023

Diagnosing normal-pressure hydrocephalus (NPH) via non-contrast computed tomography (CT) brain scans is presently a formidable task due to the lack of universally agreed-upon standards for radiographic parameter measurement. A variety of radiological parameters, such as Evans’ index, narrow sulci at high parietal convexity, Sylvian fissures’ dilation, focally enlarged sulci, and more, are currently measured by radiologists. This study aimed to enhance NPH diagnosis by comparing the accuracy, sensitivity, specificity, and predictive values of radiological parameters, as evaluated by radiologists and AI methods, utilizing cerebrospinal fluid volumetry. Results revealed a sensitivity of 77.14% for radiologists and 99.05% for AI, with specificities of 98.21% and 57.14%, respectively, in diagnosing NPH. Radiologists demonstrated NPV, PPV, and an accuracy of 82.09%, 97.59%, and 88.02%, while AI reported 98.46%, 68.42%, and 77.42%, respectively. ROC curves exhibited an area under the curve of 0.954 for radiologists and 0.784 for AI, signifying the diagnostic index for NPH. In conclusion, although radiologists exhibited superior sensitivity, specificity, and accuracy in diagnosing NPH, AI served as an effective initial screening mechanism for potential NPH cases, potentially easing the radiologists’ burden. Given the ongoing AI advancements, it is plausible that AI could eventually match or exceed radiologists’ diagnostic prowess in identifying hydrocephalus.
UAV Digital Twin Based Wireless Channel Modeling for 6G Green IoT
Authors: Qi Fei , Xie Weiliang , Liu Lei , Hong Tao , Zhou Fanqin
Published: September 2023

This paper explores the advancements of drones in the context of sixth-generation mobile communication technology (6G) green Internet of Things (IoT) through the utilization of digital twin (DT) technology within unmanned aerial vehicle (UAV) networks. We propose a framework for DT-based UAV applications in the realm of green IoT, where distinct tasks within the digital twin interact with physical-world UAVs through task manager scheduling. We characterize the radio frequency (RF) attributes of the DT using three-dimensional (3D) millimeter-wave (mmWave) radar imaging on UAVs. The wireless channel modeling, based on ray tracing, underscores the alignment of RF domains between the DT and the physical UAV in a bid to take advantage of multipath reflections and save communication energy. Our numerical findings have justified the efficacy of the drone-enabled DT platform in achieving accurate RF representation of UAVs for the intelligent operation and management of IoT-based green UAV networks.
Effective Excess Noise Suppression in Continuous-Variable Quantum Key Distribution through Carrier Frequency Switching
Authors: Dong Jing , Wang Tao , He Zhuxuan , Shi Yueer , Li Lang , Huang Peng , Zeng Guihua
Published: September 2023

Continuous-variable quantum key distribution (CV-QKD) is a promising protocol that can be easily integrated with classical optical communication systems. However, in the case of quantum-classical co-transmissions, such as dense wavelength division multiplexing with classical channels and time division multiplexing with large-power classical signal, a quantum signal is more susceptible to crosstalk caused by a classical signal, leading to signal distortion and key distribution performance reduction. To address this issue, we propose a noise-suppression scheme based on carrier frequency switching (CFS) that can effectively mitigate the influence of large-power random noise on the weak coherent state. In this noise-suppression scheme, a minimum-value window of the channel’s noise power spectrum is searched for and the transmission signal frequency spectrum shifts to the corresponding frequency to avoid large-power channel noise. A digital filter is also utilized to filter out most of the channel noise. Simulation results show that compared to the traditional fixed carrier frequency scheme, the proposed noise-suppression scheme can reduce the excess noise to 1.8%, and the secret key rate can be increased by 1.43 to 2.86 times at different distances. This noise-suppression scheme is expected to be applied in scenarios like quantum–classical co-transmission and multi-QKD co-transmission to provide noise-suppression solutions.
Edge–Cloud Collaboration-Based Plug and Play and Topology Identification for Microgrids: The Case of Jingshan Microgrid Project in Hubei, China
Authors: Yang Zhichun , Han Ji , Wang Qihang , Zhang Kai , Deng Yuting , Yang Fan , Lei Yang , Hu Wei , Min Huaidong
Published: September 2023

The rapid advancement of renewable energy technologies necessitates innovative solutions for the efficient deployment and management of microgrid systems. This paper presents a detailed study on the implementation of edge–cloud collaboration-based plug and play (PnP) and topology identification for microgrids, focusing on the Jingshan AC/DC Microgrid Cluster System (JS-MCS) in Hubei, China. Firstly, the paper elucidates the structure of JS-MCS’s physical system and integral information system, comprising the cloud platform, communication network, edge unit, and terminal unit. The following sections introduce the methods of PnP, describing the overall procedure and specific implementations between cloud and edge and cloud and terminal. Then, a novel approach for topology identification is further explored based on correlation analysis. An exemplary analysis of the studied system, JS-MCS, accentuates practical insights into the application of PnP and topology identification methods.
A Method to Obtain Lightning Peak Current in Indonesia
Authors: Denov Bryan , Hidayat Syarif , Suwarno  , Zoro Reynaldo
Published: September 2023

Lightning is a modern societal problem that continues to increase in line with technological growth. Today’s infrastructure is very vulnerable to disturbances caused by weather conditions. The most influential weather phenomenon in this regard is the weather produced by cumulonimbus (CB) clouds. Almost every year, tanks and refineries in Indonesia explode due to lightning strikes. Furthermore, there have been several instances of outages in transmission and distribution lines, as well as lightning-related fatalities in mining areas. Lightning characteristics are widely used as important data for designing lightning protection systems. However, in Indonesia, there is still a need to obtain proper lightning characteristic data. Indonesia is a maritime country located in the tropics, making its geographical conditions highly conducive to the formation of cumulonimbus (CB) clouds. Therefore, this paper presents direct lightning peak-current measurements using magnetic tape, which has been installed in several provinces in Indonesia. The paper reports the local lightning characteristics for these provinces and presents a method for obtaining lightning data. To efficiently collect lightning data on a large scale, we propose a measurement system consisting of a lightning-event counter and magnetic tape. While magnetic tape has been widely used in laboratory testing, this research discusses its application and measurement results in natural lightning conditions in the field. The novel lightning characteristics obtained for several provinces in Indonesia are expected to assist professionals in designing lightning protection systems that match the local lightning characteristics, ultimately minimizing the impact of lightning damage.
A Comprehensive Review on Transient Recovery Voltage in Power Systems: Models, Standardizations and Analysis
Authors: Lazzari Eleonora Fripp , de Morais Adriano Peres , Ramos Maicon , Ferraz Renato , Marchesan Tiago , Bender Vitor Cristiano , Carraro Rodinei , Fontoura Herber , Correa Cristian , Resener Mariana
Published: September 2023

Electrical power systems are exposed to transient disturbances that change the voltage and current signals of the network, which can interrupt power and damage equipment. In high-frequency phenomena, it is essential to study the transient recovery voltage (TRV) to ensure the electrical insulation limits of circuit breakers are not violated, thus leading to a safe and reliable operation. Adequate models are crucial to achieving satisfactory results in the studies, according to the range of frequency of the transient being evaluated. This paper presents a comprehensive literature review of methods and models for studying electromagnetic transients, focusing on TRV requests imposed on circuit breakers, in addition to fault-clearing simulations on real system modeling. The analyses are fundamental both for the evaluation of the amplitude of the voltage signal and for its rate of rise. We also compare the reviewed models and techniques to provide a handy resource for researchers.
Anti-Dyslipidemic and Anti-Diabetic Properties of Corosolic Acid: A Narrative Review
Authors: Cannarella Rossella , Garofalo Vincenzo , Calogero Aldo E.
Published: September 2023

Corosolic acid (CA), a natural compound derived from the Banaba tree (Lagerstroemia speciosa), has attracted attention for its potential therapeutic properties in the management of metabolic diseases. This narrative review aims to summarize the current evidence on the anti-dyslipidemic, anti-diabetic, and anti-inflammatory effects of CA and to understand the pharmacokinetics and molecular mechanisms through the analysis of preclinical and clinical studies.
Investigation of Proliferative Kidney Disease in Brown Trout and Habitat Characteristics Associated with a Swiss Wastewater Treatment Plant
Authors: Saura Martinez Helena , Egloff Nicole , Schmidt-Posthaus Heike
Published: September 2023

Wastewater treatment plants (WWTP) play a critical role in mitigating adverse environmental impacts of urban and industrial wastewater by removing pollutants and reducing the risk of contamination. Discharges of treated effluents from WWTPs can still have significant effects on freshwater ecosystems, particularly on sensitive species like brown trout. We analyzed the effects of a modern WWTP on a freshwater ecosystem, studying fish biodiversity and biomass, the occurrence of the parasitic disease Proliferative Kidney Disease (PKD) on brown trout, river water temperatures throughout the year and fish habitat and diversity. No major differences between up- and downstream of the WWTP were observed in habitat structure and attractiveness, fish biomass and species diversity, nor in PKD prevalence or intermediate host presence. However, immediately at the WWTP’s effluent and continuing downstream, the water temperature rose by almost 1 °C. While WWTPs are crucial for reducing the environmental impact of urban and industrial wastewater, their effluents can still have important consequences for freshwater ecosystems. Brown trout are particularly susceptible to increases in water temperature, especially regarding PKD severity and consequent mortality. To ensure the long-term health and sustainability of freshwater ecosystems, it is imperative to improve measures to minimize water temperature rises and mitigate downstream cascade effects on sensitive organisms like brown trout.
Integrated Multimodal Omics and Dietary Approaches for the Management of Neurodegeneration
Authors: Murai Toshiyuki , Matsuda Satoru
Published: September 2023

Neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, are caused by a combination of multiple events that damage neuronal function. A well-characterized biomarker of neurodegeneration is the accumulation of proteinaceous aggregates in the brain. However, the gradually worsening symptoms of neurodegenerative diseases are unlikely to be solely due to the result of a mutation in a single gene, but rather a multi-step process involving epigenetic changes. Recently, it has been suggested that a fraction of epigenetic alternations may be correlated to neurodegeneration in the brain. Unlike DNA mutations, epigenetic alterations are reversible, and therefore raise the possibilities for therapeutic intervention, including dietary modifications. Additionally, reactive oxygen species may contribute to the pathogenesis of Alzheimer’s disease and Parkinson’s disease through epigenetic alternation. Given that the antioxidant properties of plant-derived phytochemicals are likely to exhibit pleiotropic effects against ROS-mediated epigenetic alternation, dietary intervention may be promising for the management of neurodegeneration in these diseases. In this review, the state-of-the-art applications using single-cell multimodal omics approaches, including epigenetics, and dietary approaches for the identification of novel biomarkers and therapeutic approaches for the treatment of neurodegenerative diseases are discussed.