bluuebunny/crossref_metadata_2025 huggingface dataset:
Avaliação morfológica de pele e intestino de peixes expostos ao corante preto reativo 5
Authors: Oliveira Danúbia Querubim , Gonçalves Daniel B , Santos Hélio Batista , Gruppi Thomé Ralph
Published: July 2019

A indústria têxtil desempenha papel importante na economia de muitos países. Entretanto, os corantes utilizados no tingimento de fibras têxteis costumam ser resistentes ao tratamento biológico, implicando na liberação de resíduos líquidos, ocasionando problemas ambientais e a saúde humana. Alguns corantes e seus produtos de degradação, especialmente do grupo azo são mutagênicos e carcinogênicos. A pele e o intestino são importantes para homeostase do organismo, despertando interesse em estudos toxicológicos. Assim, o presente trabalho tem como objetivo avaliar a morfologia da pele e intestino de peixes expostos ao corante Preto Reativo 5. Para o ensaio toxicológico, 24 animais, Danio rerio, foram divididos em quatro grupos: Controle (água da torneira); I (6 ppm); II (8 ppm) e III (10 ppm). Animais inteiros, foram submetidos as técnicas histológicas de rotina e imunohistoquímicas. Análises morfométricas foram realizadas no intestino delgado e na pele da região ventral. Não houve mortes durante a experimentação, os peixes mantiveram comportamento normal de natação e de alimentação. Em todos os animais, os tecidos do intestino e da pele apresentaram arquiteturas morfológicas sem modificações. Necrose, apoptose, formação de edema e perda de aderência não foram observados. A pele apresentou aumento de células mucosas e da espessura da pele (p<0,05). No intestino observou-se aumento das vilosidades intestinais, de células em proliferação e células caliciformes (p<0,05). Através do presente trabalho foi possível confirmar a subletalidade das concentrações estudadas e foi demonstrando que essa exposição ao corante PR5 causa alterações em órgãos chaves que podem comprometer o funcionamento.
Anemia de doença crônica na doença renal crônica
Authors: Oliveira Junior Wander Valadares de , Lorena Alexandre Zica Catarina , Silva Oliveira Tayná , Pabline Pereira de Gouveia Ingit , Ramos de Oliveira Roselaine , De Oliveira Vasconcelos Mariana
Published: July 2019

Introdução: A Anemia de doença crônica (ADC) é classificada como o tipo de anemia que surge quando há alguma doença de base de característica crônica, seja ela infecciosa, inflamatória ou neoplásica. Em pacientes portadores de Doença Renal Crônica (DRC), a fisiopatologia da ADC manifesta-se quando há uma resposta imunológica mediada por citocinas que causam um aumento da ferritina, retendo mais ferro nos macrófagos. O diagnóstico da ADC é feito por intermédio da avaliação clínica do paciente e exames laboratoriais. No que diz respeito ao tratamento, deve-se adotar medidas terapêuticas como reposição do ferro, administração de eritropoietina e em alguns casos transfusão de concentrado de hemácias. Objetivo: fazer uma revisão narrativa da literatura envolvendo os diversos fatores relacionados com a anemia na DRC. Metodologia: Busca consolidada por meio de artigos científicos, teses, resenhas e dissertações, nas bases de dados Scielo, PubMed, Google Acadêmico, Portal de Periódicos CAPES e Biblioteca Virtual de Saúde (BVS) usando as palavras chaves “anemia de doença crônica” and“doença renal crônica”. Conclusão: A fim de se evitar a evolução da doença é essencial um diagnóstico e tratamento precoce, neste sentido o profissional da biomedicina cumpre um importante papel, seja no diagnóstico, monitoramento ou na pesquisa por novos métodos terapêuticos.
Indicadores de saúde e aptidão física em escolares do Ensino Médio da Universidade Federal de Viçosa – Campus Florestal
Authors: Leite Daniel Massote de Melo , Trigo Ricardo Wágner de Mendonça , Silva Willy Sanches da
Published: July 2019

Introdução: Atualmente o estilo de vida adotado por escolares tem trazido grandes modificações relacionadas à aptidão física para a saúde. A avaliação da aptidão física permite averiguar as condições do indivíduo para melhorar sua capacidade física e qualidade de vida. Objetivo: Analisar as informações sobre as variáveis de composição corporal e aptidão física para a saúde coletados em escolares do Ensino Médio por meio de testes do Manual PROESP-BR. Metodologia: Este estudo caracterizou-se ser de caráter avaliativo qualitativo de dados secundários coletados a partir do PROESP-BR. Para participar do estudo os escolares deveriam ter menos de 18 anos e estarem matriculados na UFV-CAF e possuir atestado médico para participação nas aulas de Educação Física. Foram analisadas as variáveis de aptidão física para a saúde. Resultados: Participaram do estudo 37 estudantes do 1º ao 3º ano. Os resultados do IMC apontaram que (17,85%) da amostra masculina está em zona de risco para a saúde, contra (11,11%) da amostra feminina. O desempenho cardiorrespiratório indicou risco à saúde em 100% da amostra feminina. No teste de resistência muscular o grupo feminino obteve classificação zona saudável em 100% da amostra. Em contrapartida, o grupo masculino apresentou valores de risco à saúde (3,57%). Na flexibilidade, 100% da amostra feminina foi classificada em zona saudável. Conclusão: Os escolares apresentaram perfil antropométrico e aptidão física para a saúde satisfatória. A utilização de testes para a avaliação da saúde de escolares foi considerada uma ferramenta útil e deve ser utilizada por professores de Educação Física.
A linguagem teleológica nas Ciências Biológicas: uma proposta de intervenção didática sobre o tema polinização
Authors: Martins Giselle Alves , Brando Fernanda da Rocha
Published: July 2019

O presente artigo tem por objetivo apresentar algumas ideias sobre Teleologia, discutindo formas de explicações científicas e filosóficas sobre o fenômeno biológico polinização. Para promover reflexões sobre a linguagem teleológica no ensino de Biologia, propõe-se uma sequência didática pautada em aspectos pedagógicos e epistemológicos, considerando as concepções de pesquisadores, alunos e professores no processo de construção do conhecimento.  A proposta discute diferentes pontos de vista de naturalistas e cientistas sobre um mesmo fenômeno e permite reflexões sobre o processo de ensino-aprendizagem que considera a natureza da ciência sob uma abordagem filosófica-histórica.
O núcleo de apoio à saúde da família (NASF) e a inserção e atuação do médico veterinário na saúde pública
Authors: Lecca Lívian Otávio , Araújo Isabela de Lourdes , Filho Rui Pitágoras de Lima Castro , De Oliveira Tiago Mendonça , Santos Mariana Avelino de Souza , Aguiar Andreza Nayla Assis
Published: July 2019

Introdução: Em 2008, para fortalecer a assistência no Sistema Único de Saúde (SUS), foi criado o Núcleo de Apoio a Saúde da Família (NASF). O NASF é formado por equipes de diversas áreas do conhecimento. O médico veterinário é um dos profissionais que pode compor as equipes do NASF, devido à sua atuação na área da saúde coletiva, zelando pela saúde humana. Objetivo: Descrever a importância da atuação do médico veterinário na Saúde Pública e a sua inserção no NASF.  Metodologia: Realizou-se uma revisão integrativa da literatura avaliando a inserção do médico veterinário no NASF. Resultado: No passado, o médico veterinário era visto exclusivamente como um profissional voltado para o atendimento aos animais. No entanto, ao longo do tempo suas competências foram ampliadas ao contexto da Saúde Pública em programas de saúde coletiva. A partir dessas competências profissionais, o médico veterinário foi inserido com o propósito de trabalhar na Atenção Básica, particularmente no NASF. Nessa perspectiva, o profissional veterinário seria capaz de integrar as competências e habilidades relacionadas à saúde humana e animal. Conclusão: A inclusão do médico veterinário nas equipes do NASF amplia a capacidade de ações práticas com foco na prevenção de zoonoses. Observa-se uma carência na formação do médico veterinário voltado para a saúde pública e uma dificuldade de integração do médico veterinário no NASF.
Ensino de Microbiologia, no 3º ciclo do Ensino Básico, através do desenvolvimento de um projeto de investigação em biorremediação
Authors: Morais Paula V , Moens Merijn , Dias Suzana
Published: July 2019

O ensino de ciências, como um processo de enculturação e construção do conhecimento, possibilita momentos de questionamentos e descobertas nos quais ocorre a identificação das necessidades do aluno e a ampliação do seu desenvolvimento cognitivo. As questões revestem-se de um importante papel na procura incessante do conhecimento, uma vez que levam à ponderação e à tentativa de encontrar respostas para resolver um problema. O ato de formular questões e de questionar, evidencia uma intenção ou um desejo de desvendar algo sobre um dado assunto e confere-se como um meio de partilha do conhecimento humano. Do reconhecimento de que a grande generalidade dos alunos adota uma postura passiva, fazendo poucas questões, e da admissão de que questionar é importante na aprendizagem dos mesmos, decorre a relevância de desenvolver um projeto de investigação científica, no âmbito da microbiologia, como forma de promover e estimular o questionamento dos alunos em Ciências Naturais, no oitavo ano, do terceiro ciclo do Ensino Básico, conduzindo a uma promoção das suas aprendizagens. No projeto PhytoFix, investiga-se o cultivo de plantas de arroz e suas bactérias endofíticas na presença de poluentes.
Métodos de sincronização de estro e ovulação em bovinos
Authors: Soares Paulo Henrique Araújo
Published: July 2019

A Inseminação Artificial em Tempo Fixo (IATF) é uma biotecnologia, que tem possibilitado aos pecuaristas, alcançarem uma alta eficiência reprodutiva do rebanho. Esta biotécnica consiste em sincronizar o ciclo estral de fêmeas bovinas, por meio da aplicação de fármacos análogos aos hormônios naturais em um período pré-determinado. Várias são as metodologias utilizadas para a sincronização do estro e ovulação, como por exemplo, a aplicação sistemática de PGF2α, o protocolo ovsynch e os protocolos a base de progestágenos. Como principais vantagens da implantação de programas de IATF, destaca-se a diminuição do intervalo entre partos, a eliminação do tempo gasto com a observação de cio e a formação de lotes homogêneos. Entretanto, existem alguns fatores que podem interferir nos resultados da IATF, sendo os principais: a condição corporal apresentada pelas vacas no pós-parto, a produtividade do animal e o vínculo materno existente. Nesta perspectiva, o presente trabalho tem por objetivo, expor como a IATF se insere no contexto da reprodução bovina, discorrendo tal assunto, através de uma revisão bibliográfica.
 
Palavras-chave: Bovinos. Reprodução Animal. Sincronização.
Comparative Study of Cryotherapy versus Trichloroacetic Acid Chemical Peels in the Treatment of Actinic Keratosis
Authors: Sabir Hawar J. , Ridha Intiha M.
Published: July 2019

Actinic keratosis is cutaneous neoplasm which is including of expansion of cytologically unusual epidermal keratinocytes that grow in response to prolonged exposure to ultraviolet radiation. Since some percentage of actinic keratosis will develop to non-melanoma skin cancers, their treatment is recommended. The study aimed to evaluate the clinical effectiveness of cryotherapy in comparison to topical 25% trichloroacetic acid chemical peels in the treatment of actinic keratosis. A comparative therapeutic study was conducted on forty four patients with actinic keratosis who attended Erbil dermatology teaching center in Erbil city of Kurdistan Region-Iraq. Patients were randomly allocated into two groups: cryotherapy treatment with liquid nitrogen every two weeks and trichloroacetic acid peels every two weeks and the response was controlled on follow up by taking photos. Patient’s age ranged from 40 to 80 years, they were analyzed for 24 weeks. Good response rate was seen in 72.8% of cryotherapy group and 40.9% of trichloroacetic acid group and this was statistically significant (p=0.02).  Cryotherapy was more effective than trichloroacetic acid in the treatment of actinic keratosis.
Effect of passive, active and combined warm up on the lower limb of healthy individuals
Authors: Priyanga Seemathan  , SujathaBaskaran
Published: July 2019

Aim of the study is to determine the effect of passive, active and combined warmup on lower limb of healthy individuals. The methodology of the study is 30 individuals based on inclusion and exclusion criteria. Detailed procedure will be explained in patient words, and informed consent will be obtained from all participants. Effect of active, passive and combined warm-up will be evaluated in the subjects. The post-test value will be taken after four weeks. The results we determined from the static analysis has been revealed that there is a significant improvement in physical fitness of combined warm-up group than the active and passive warm-up separately. In the vertical jump test for passive warm-up group, the pre-test mean is 37.71, with the standard deviation being 6.53 and the post-test mean being 38.24 with a standard deviation of 6.60. And for the active warm-up group, the pre-test mean is 38.69, with the standard deviation being 6.606 and the post-test mean being 39.4 with a standard deviation 6.65. And for the combined warm-up group, the pre-test mean is 38.94, with the standard deviation being 7.12 and the post-test mean being 40.57 with a standard deviation of 6.88. Hence, we conclude that it has been proved statistically that although improvements have been observed in three groups, the improvement is much more significant in the combined warm-up group.
An investigation of bioactive and free radical scavenging potential of moringa Oliefera leaf extracts
Authors: Uzma Sayyed  , Pratibha Pandey  , Rohit K. Tiwari  , Rafia Shekh  , Preeti Bajpai
Published: July 2019

Moringa oleifera Lam, commonly known as Sehjan belongs to the Moringaceae family. It is widely used for the treatment of infectious and inflammatory diseases. This study was an attempt to evaluate the morphological characteristics, percent yield, the bioactive and antioxidant potential of M. oleifera leaves that would help in elucidating a promising therapeutic and curative agent for the treatment of different ailments. The maximum percentage yield was obtained in methanolic extract (29.55%) of M. oliefera leaves. Qualitative analysis also revealed the maximum presence of all the metabolites in methanolic extract. Quantitative analysis revealed an appreciable presence of phenol (53.1 mg/g) flavonoids (47.7mg/g) and carotenoids (16.46 mg/g) in M. oleifera leaves. The methanolic extract had shown the maximum antioxidant potency in a dose-dependent manner during the evaluation of enzymatic (SOD and CAT) and nonenzymatic (DPPH and FRAP) antioxidants with minimum IC50 value. Thus, it could be concluded from the present study that methanolic leaf extract of M. oliefera could be amongst the principle extract for the antioxidant activity of M. oliefera, which could be used for the treatment of several ailments.
Correlation of pupil to limbus diameter ratio (PLD ratio) with blood pres-sure and pulse rate in hypertensive males
Authors: Harini Krishnan  , Archana R  , Kannan Rajendran
Published: July 2019

Hypertension is known to be a major risk factor for coronary artery disease, stroke, heart failure, vision loss which remains asymptomatic until late in its course and even severely elevated pressures can be clinically silent for years.  Measurement of diameter of the pupil is indicative of autonomic function, and recording of the pupil to limbus diameter (PLD) ratio correlates with alterations in blood pressure.  As hypertension is more prevalent in males and the incidence is increasing year by year, measurement of PLD ratio can be used as a simple screening tool in the general population to measure the autonomic alterations associated with changes in blood pressure.  This study aims at finding the correlation of pupil to limbus diameter (PLD) ratio with blood pressure and pulse rate in Hypertensive Males.  45 male patients attending O/P of Saveetha Medical College and Hospital in the age group of 30 to 65 years, fulfilling the inclusion criteria were enrolled in the study.  It's a case-control study with non-probability convenient sampling.  Blood pressure, using a sphygmomanometer and pulse rate were measured by the physician according to AHA criteria, and PLD ratio was assessed by the two-box method.  There was a significant decrease observed in PLD ratio when normal and hypertensive groups.  Mean pulse rate of hypertensive males was significantly higher compared to the control group.  The systolic blood pressure and diastolic blood pressure were significantly high in hypertensive male patients.  A significant difference in PLD ratio exists between the control and hypertensive males though no positive correlation was observed.
Efficacy of navaka guggulu in the management of obesity: A case study
Authors: Sherly Deborah G  , Archana R  , Suprava Das  , Myat Thu Thu Win  , Usha Kumari
Published: July 2019

Obesity is a global public health problem because of its increased prevalence and health effects. It is the most common disorder encountered in clinical practice, which has serious social and psychological dimensions that affect all age groups. A 28-year old married obese male whose body weight and height were 97 kilograms and 5.9 feet respectively showed a body mass index (BMI) of 30. All the examinations and tests were normal before the study. There were 3 weight reduction regimes that included only walking in the morning during the first month, followed by walking with dieting in the second month and in addition to dieting and walking, two tablets of Navaka Guggulu was prescribed to be taken daily. The vital signs, bowel habits, micturition habits and appetite were assessed daily. After the interventions, the weight reduction was observed at 0.5, 0.8 and 4.7 kgs at the end of the first, second and fourth month, respectively. The results of routine blood parameters, autonomic function tests and respiratory function tests were normal with an increase in the haemoglobin level, high-density lipids and a decrease in the total cholesterol level, triglycerides, low-density lipids and very low-density lipids. The present study showed that Navaka Guggulu was not only beneficial but also safe and efficacious in the treatment of obesity.
Effect of endurance exercise on attention and depression in Parkinson’s disease patients - A new approach
Authors: Sujatha B  , Sarumathi S  , Tinu Priya R
Published: July 2019

Aim of the study is to determine the effects of endurance exercise on depression and attention deficiency in people with Parkinson’s disease patients. The methodology of the study is,15 participants with Parkinson's disease were selected both male and female from the neurological rehabilitation centre, Chennai. The purpose and procedure of the study were completely explained to the participants, and informed consent was obtained from all the participants. Depression scale and the digit-symbol task was evaluated before starting the exercise program and participants were randomized into two groups (Group A and Group B). This study compared the effect of endurance exercise to stretch-balance training. The exercise program was given for a duration of 12 weeks. After 12 weeks, Hospital anxiety & depression scale and digit-symbol task were used to check for the progress. The result we determine from the statistical analysis, it has been revealed that depression symptoms decreased with endurance exercise and stretch-balance training but didn't show any significant improvement on attention with endurance exercise while with stretch-balance training it shows minimal improvement. Hence, we conclude that endurance exercise is a viable intervention in PD that can be used as a protective technique against depression symptoms and can also be used for improving attention in people with Parkinson’s.
Phytochemical, Antioxidant, Anti-stress and Cerebro-protective activity of ethyl acetate extract of bark of Entada rheedi
Authors: Marasani Anil  , Swarna Latha D  , Eswar Kumar K
Published: July 2019

Entada rheedi is claimed to have antistress activity by folklore which is available abundantly in several places of India. The present study was planned to evaluate the phytochemical, anti-oxidant, anti-stress and cerebroprotective activities of ethyl acetate extract of bark of Entada rheedi (EAER). The bark of Entada rheedi was collected and extracted with ethyl acetate. The ethyl acetate extract was subjected to phytochemical screening (chemical and HPTLC), antioxidant (in-vitro), anti-stress (mice model) and cerebroprotective activities (cerebral ischemia model). EAER showed the presence of flavonoids as primary phytoconstituents. EAER significantly reduced the immobility time in swimming endurance and tail suspension test. EAER significantly reduced the TBARS levels and augmented tissue antioxidants in restraint stress model and cerebral ischemia model. The levels of MOA-A were reduced in the EAER treated animals and cortisol levels also reduced in EAER treated animals. Histopathology also supported the biochemical parameters. The EAER effect was compared with reference standard diazepam and Ashwagandha. EAER showed significant antioxidant, anti-stress and cerebroprotective activities and the protective effect could be due to the presence of flavonoids as phytoconstituents.
Development of Graphical User Interface to Classify Cardiac Abnormalities using ECG Signal
Authors: Sharanya S  , Sridhar PA  , Suresh MP  , Poorana Mary Monisha W  , Tharadevi R
Published: July 2019

Analysis of Electrocardiogram (ECG) signal can lead to better detection of cardiac arrhythmia. The important steps involved in the ECG signal analysis include acquisition of data, pre-processing of signal to remove artefacts, feature extraction of attributes and finally identifying abnormalities. This work proposes an efficient implementation of the R-R interval-based ECG classification technique for detecting abnormalities in heart functioning. ECG signals from an online database (PhysioNet.org) was analysed after noise removal for R-R interval, as R peak has the maximum prominent amplitude in ECG wave. Deviation in the R-R interval values obtained from unhealthy was observed and compared with healthy subjects. This observation of cardiac activity can be visualised in our developed Graphical User Interface (GUI). The GUI platform requires only the input of the ECG signal that is to be analysed for abnormalities, which can provide the clinician with the result of cardiac abnormality classification and can help in diagnosis.
Sequencing and structure analysis of UBC gene for breast and ‎lung cancer
Authors: Saleen Salam Abdulhadi  , Abbas Abdullah Mohammed‎
Published: July 2019

In the present study, sequencing approach has been adopted for exploring the ‎genetic alteration of sequences for the ubiquitin gene (UBC) in patients of breast and ‎lung cancer and comparing the results with a normal sequence that obtained from NCBI. ‎The aim of this study was to detect for genetic alterations of UBC gene in the breast and ‎lung cancer patients then compare with healthy control subjects, to investigate the ‎association between the mutations at the intron region of the UBC gene and cancer disease, ‎‎40 blood samples were examined from patients with breast and lung cancer aged ranged from (17-65) years, were collected at Al-Amal Hospital of cancer in Baghdad ‎province/Iraq, the period of collecting samples were from October/2018 to January/2019. ‎While twenty-two blood samples from healthy control subjects were collected at ages ‎ranged from(19-59). After DNA extraction, the PCR primer was designed to amplify the ‎region in the UBC gene (part of exon 1 and the whole intron). Here we report the polymorphism of the intron sequence of the UBC gene in Iraqi population as the results of sequencing the PCR amplified products showed three different transition mutation G→A, ‎C→T, T→C in patients with breast cancer were also appeared in healthy control subjects. While nine transition mutations appeared in lung cancer patients, at different locations ‎of the sequence were detected by BLAST tool. ‎
Optimization of extraction process for extract yields, total flavonoid content, radical scavenging activity and cytotoxicity of Curcuma aeruginosa RoxB. rhizome
Authors: Eka Nurul Qomaliyah  , I Made Artika  , Waras Nurcholis
Published: July 2019

The rhizome of Curcuma aeruginosa RoxB. (RCA) is used traditionally for several diseases. The flavonoid compounds contained in the RCA that responsible for biological activities. In this study, ethanol, water, and acetone had been used as solvent extraction of RCA and applied the simplex-centroid design to optimize the extraction process. The radical scavenging activity and total flavonoid content were investigated using in vitro assays, while cytotoxicity was evaluated by brine shrimp lethality test. ANOVA suggested a linear model for all responses. The ethanol: acetone extract had the highest extract yield with a value of 25.15%, and this result showed no significant with acetone extract at p < 0.05 (22.86%). The ethanol extracts confirmed the higher degree of total flavonoid content and cytotoxicity with a value of 17.97 mg QE/g and 140 μg/ml, respectively. The ethanol: water extract, ethanol extract, and water extract (IC50, 100-500 μg/ml) showed moderate radical scavenging activity compared with ascorbic acid (IC50, 7.19 μg/ml). Regarding the correlation analysis, the negative correlation was weakly observed between flavonoid content and IC50 of free radical scavenging activity, which indicates that the flavonoid in RCA contributes not significantly to the antioxidant activity. Introductory studies on the extraction process of the advanced flavonoid extracts exhibited a scavenging and cytotoxic effect of the ethanol extract on C. aeruginosa rhizome.
Comparative molecular study between some plant extract and tinidazole on hydatid cysts in Basra, southern Iraq
Authors: Jalal Y. Mustafa  , Ghazi Y. Azal  , Suzan A. Al-Azizz  , Fatin A. Muatafa  , Arwa R. Lazim
Published: July 2019

Hydatid disease or Echinoccosis is one of the serious public health problems. This study was designed as a comparative molecular study between some plant extract and tinidazole of sheep hydatid cysts in Basra province. In this study, 213 sheep were examined and the number of those infected with hydatid cysts was 75 (35.2 %). The results showed that hydatid cyst was detected successfully by performing PCR technique. In addition, Quercus aegilops has been shown the best plant extract for destroying all genes, the second plant extract which is Capparis spinosa showed destroying of two genes (G6-7, COI) and failed to destroy (sh4-1). Furthermore, Prosopis fracta has shown to destroy only (G6-7) and tinidazole failed to destroy any of these genes used in this study.
Molecular study of hydatid cysts in human, sheep and donkeys at basra city, southern iraq
Authors: Jalal Y. Mustafa  , Suzan A. Al-Azizz  , Arwa R. Lazim
Published: July 2019

Hydatid disease or Echinoccosis is one of the serious public health problems. This study designed for molecular investigation of Hydatid cysts in different hosts animals (Sheep, donkey) and human in Basra city, as well as molecular characterization by PCR technique to determine the specific gene for human (ND1, COI, CO1), sheep (G6-7, sh4-1, COI) and donkey (COI, CO1). Then, gene sequencing to recognize the intraspecific variation of Echincoccus in relation to host. In the current study, 818 sheep were examined and the number of sheep infected with hydatid cysts was 271. Donkey samples (10) were brought to the animal field of Veterinary Medicine at the University of Basra and the number of infected with hydatid cysts was two in the period from September 2017 to March 2018. The hydatid cysts were collected from the human after surgery at Al-Sadr Teaching Hospital where 21. The results were higher in female (15) than male (6) in the same period.
Impact of plasma neutrophil gelatinase-associated lipocaline level on early outcome of a patient with ST-segment elevation myocardial infarction
Authors: Sadiq J. Al-Muhana  , Zahraa Abdulaali Al-Mudhafar  , Rawaa Bahlool  , Safaa Imran Musa  , Najah R Hadi
Published: July 2019

In patients with the atherosclerotic arteries, Neutrophil gelatinase-associated lipocaline (NGAL) may play a part in vascular remodeling and the instability of atherosclerotic plaques. Patients with angiographically documented coronary artery disease have significantly higher levels of serum NGAL compared with persons with normal coronary arteries.This study aims to determine the short term prognostic value of NGAL serum levels in a patient with acute ST-segment elevation myocardial infarction. This is study enrolled twenty patients with acute ST-elevation myocardial infarction (STEMI) and twenty healthy subjects as control. Serum NGAL level was compared between the patients and control and then correlated with early outcome of the patients.There was a significant elevation of serum NGAL in STEMI patients COMARED    with control, and significant relationship was observed between admission serum NGAL early complications and mortality.High NGAL level associated with poor outcome in STEMI patients and can be use as initial indicator for close monitoring of high-risk patients.
Development and validation of chemometric assisted analytical methods for simultaneous estimation of Atorvastatin calcium and Aspirin in capsule dosage form
Authors: Keerthisikha Palur  , BharathiKoganti  , Sreenivasa Charan Archakam
Published: July 2019

To develop two Chemometric-assisted analytical methods like UV spectrophotometry and RP-HPLC methods for the quantification of Atorvastatin calcium (ASC) and Aspirin (APN) in the capsule dosage form. Chemometric models used in UV spectrophotometry were Principal component regression model (PCRM) and Partial least-square regression (PLSR). Both the models were applied for the drugs in the calibration ranges of 4-20 and 30-150 μg/mL for ASC and APN respectively. Total of nineteen laboratory prepared mixtures were used for calibration and prediction set of the models. In addition, RP-HPLC method by using chemometric approach for was developed using C18 column at room temperature with a mobile phase of acetonitrile: methanol: triethylamine (53.1:11.9:35 v/v/v), pH- 3.0, with detection at 275 nm. PCRM and PLSR models were evaluated by statistical parameters and RP-HPLC method was optimized by using Response surface methodology. The developed methods like UV and RP-HPLC by using chemometrics showed almost similar results and both the methods can be used for their analysis.
Optimization of linseed cultivation, a promising way to enhance its secoisolariciresinol diglucoside lignan content
Authors: Amira S. El Senousy  , Sabah H. El Gayed  , Saber H.A. Mostafa  , Saeed Z.A. Zidan  , Mohamad Louai M. Hariri  , Nebal D. El Tanbouly  , Essam Abdel-Sattar
Published: July 2019

There is strong evidence on the anticancer properties of secolariciresinol diglucoside (SDG), the predominant flaxseed lignan, especially for mammary and prostatic carcinomas. Although the effect of cultivar and location on flaxseed SDG level has been reported, much less is traced regarding the influence of agronomical treatments. The purpose of this study is to determine if agricultural management practices could enhance SDG accumulation in flaxseed. We studied the effect of irrigation frequencies (I), added nutrients (N, zinc and humic acid) and fertilization treatments (F) and their interactions on SDG level and seed yield of the Egyptian flax cultivar Giza 9. Samples were extracted and analyzed for SDG, after alkaline hydrolysis, using HPLC-UV method. The concentration of SDG and its yield varied between 415.55-845.95 mg/100 g whole seeds and 1.77-4.05 Kg/feddan on a dry weight basis, respectively according to different agricultural treatments. I, N and F factors and their interactions had a significant effect on SDG. I × N × F interaction contributed to the majority of SDG variation (31.81 %), followed by I factor (27.96 %), whereas seed yield was more affected by F factor (72.7 %). The I × F interaction was the only significant interaction on the seed yield contributing only for 0.43% of the variance. Moderate irrigation frequency with the humic acid foliar application and mineral nitrogen fertilizer was the best combination for achieving the highest SDG levels. Using optimum agronomic practice would benefit the nutraceutical industry by optimizing flaxseed lignan content and hence enhancing its anticancer, health-promoting effect.
Development of nano structured lipid carrier based hydrogel for the treatment of psoriasis
Authors: Vishal Gupta N  , Kowshik K  , Nikita Sehgal
Published: July 2019

The present work aimed to develop Nanostructured Lipid Carrier Based Hydrogel for the treatment of psoriasis, delivered as a topical application on to the skin. Nanostructured Lipid carrier based Hydrogel loaded with methotrexate is a new technique for topical administration for psoriasis. Methotrexate loaded NLC's were prepared by a hot homogenization method using high-pressure homogenizer. Stearic acid and oleic acid were selected as the solid lipid and liquid lipid, respectively. Tween 80 used as a surfactant. The developed lipid formulations were incorporated in 1% Carbopol 934 gel medium to maintain the topical application consistency. Fourier-Transform Infrared Spectroscopy was employed to identify their functional groups. Differential Scanning Calorimetry was employed to determine its melting point. The particle size, zeta potential, polydispersity index for the MTX-NLC were found to be 239.12±3.65nm, -24.61mV and 0.245 to 0.517. Scanning electronic microscopy studies will reveal the surface morphology of the nanoparticles. The pH of the drug-loaded formulation was in the range of 4.93 to 5.83. Spreadability was in the range of 3.01±0.59cm to 8.13±0.34cm. Viscosity at 25±2oC was 67325 cps.  In vitro studies suggest that initial release rate was observed within first 4 hrs and amount of drug release was 35 to 47± 3.61%, fast and sustained release rate reached by 24th hr and release rate of the drug was 72%.  The stability studies reported that the formulation was stable for 30 days after the incorporation of the drug, and there was no drug degradation or decomposition and no change in physical appearance. Hence, results indicate the sustain release activity of MTX-NLC Hydrogels, which could help in preventing the cell division and proliferation of cell acting as a major barrier in the topical application of psoriasis.
Nephroprotective potential of Neermulli/Nerunjil Kudineer on Cisplatin induced nephrotoxicity in Wistar albino rats
Authors: Noorul Alam  , Gopal V  , Vasanthi C  , Prabal Kumar Manna
Published: July 2019

Nerunjil kudineer/Neermulli Kudinner is an official Siddha polyherbal formulation used for the various ailments related to the kidney. Cisplatin is an alkylating agent used in chemotherapy for the treatment of various cancers. Its use is limited due to their nephrotoxicity. In this study nephroprotective effect of Nerunjil kudineer (NK) on cisplatin-induced nephrotoxicity in Wistar albino Rats was studied. Male Wistar albino rats were used for this study. Animals were divided into 5 groups (n=6) as control, Cisplatin control (Single dose 7 mg/Kg i.p on the 7th day), Cisplatin with Cystone (p.o), NK200 and NK400 mg/Kg (p.o) for 10 days. At the end of the study, animals were weighed and sacrificed to estimate the relative kidney weight, serum creatinine and Urea. Kidney tissue was estimated for oxidant-antioxidant parameters (MDA, GSH & SOD) and histology study was carried out. Cisplatin reduced body weight and increased kidney weight significantly (P<0.0001). It deprived the renal function by elevating serum creatinine & urea, MDA and reduction in endogenous antioxidants GSH and SOD significantly (P<0.0001). Cisplatin group exhibited focal tubular necrosis and congested blood vessels in histology study. The standard drug Cystone and NK400 significantly increased the body weight, reduced the kidney weight, normalized the kidney function parameters (Serum Cr and Urea), bolstered antioxidant status and showed a trend towards the recovery of histological alterations. NK showed a dose-dependent activity and higher dose, NK400mg /Kg possessed strong nephroprotective activity, which may be due to the efficient antioxidant potential, which reduces lipid peroxidation and oxidative stress induced by cisplatin. The results strongly suggest that Nerunjil kudineer is an effective nephroprotective drug against Cisplatin induced nephrotoxicity.
Uranium concentration variation dependency on gender correlated with age of bladder cancer patient
Authors: Aseel S. Mahmood  , Omar Sh. Shafeq  , Mohamed S. Shafiq
Published: July 2019

Human health was and still the most important problem and objective of all most researches. Finding out what causes in the decadence of healthiness of Iraqi population is our tendency in the present work, Uranium causing cancer that is affected by a correlation between age and gender of bladder cancer patients is studied in the present work. Mean of Uranium concentration (Uc) decreased with increasing age for all age group without dependency on gender. While, there is a wide dispersion in Mean Uc excretion between males and females, due to the effect of correlated gender with age, where female Mean Uc is maximum at age 50-69 year (2.355 µg/L), and it's higher than male Mean Uc (2.022 µg/L) in this age stage because of menopause, also average period of illness and the percentage of patients are affected by correlated gender with age. So that factor of gender correlation with age affects in the calculation of background levels and radiation exposure and causing bladder cancer incidence.
Vacuum-assisted closure dressing in split-thickness skin grafting
Authors: Ali A Ali  , Yasir N Qassim  , Ali N Areef
Published: July 2019

Vacuum-assisted closure (VAC) has been applied to a variety of acute and chronic wounds that are difficult to manage, and is associated with improved wound healing outcomes. It involves the application of sub-atmospheric pressure in a controlled way to secure a split-thickness skin graft on the wound that has been sealed with an occlusive dressing.A study was conducted on the patients with a variety of indications for skin grafting, admitted to Azadi Teaching Hospital between March 2010 and August 2017. After the application of split-thickness skin graft, a closed, controlled suction was applied on the wound. The graft was then continuously observed, and the dressing was changed as needed.A total of 39 split-thickness skin grafting procedures were performed on 37 patients (20 male, 17 female), the age of the patients ranging between 7 and 68 years. The average grafted area was 12±70 cm2, and the percent graft take ranged from 90 - 100%.Vacuum-assisted closure opposes the graft firmly on the wound bed, sucks out the seroma and/or hematoma, prevents shearing of the graft and aids in immobilization of the grafted part; thus improving the quantity and quality of the graft take. This study also established that VAC was particularly useful when the wound site is difficult to access, the wound is highly contoured and the conditions are less-than-ideal for complete graft take.
Absent vagina a description of cases with varied ages, presentations and reconstructions
Authors: Ali Adwal Ali  , Khalida M. Amin  , Emil N. AZZO  , Ayla K. Kahya
Published: July 2019

The aim is to describe cases of vaginal agenesis of varied ages presentations and managements and report the outcome of interventions regarding restoration of continuity of reproductive tract and normal sexual activity. A prospective descriptive case series study.  Five female patients with vaginal agenesis were recruited from November 2005 to November 2016. Three were adolescents and had a functioning uterus. Three patients underwent vaginoplasty using McIndoe method, one had vagino-vaginal anastomosis, and the other had hysterectomy to remove source of menstruation. Age ranged from 12 to 24 years. The outcome of vaginoplasties to the 2 young females and to one of the adolescent girls was adequate vagina, whereas the other 2 adolescent girls had failed redo vaginoplasty and ended with a patent narrowed vagina in one and a closed vagina in the other which required a hysterectomy. On Follow up (range 5 - 42 months) 2 of the adolescent’s girls had regular menstruation with no pain and pelvic collection, while the third one had amenorrhoea following a hysterectomy. The 3 patients who had successful vaginoplasty got married and enjoyed satisfactory intercourse. Patients with absent vagina presents at variable ages depending on whether a functioning uterus is present or not. The success of vaginoplasty is less when it has to be done in adolescence than when it is done in adulthood when patient is grown-up. Best outcomes require accumulative experience, ideally with the aid of doctors of other specialties.
Serological markers of autoimmunity ‎in women with polycystic ovary ‎syndrome
Authors: Wasan Wajdi Ibrahim  , Ekhlas Jabbar Kadhim  , Nada Saeed Abbas  , Saba Ryadh ‎Younis  , Hayder Adnan Fawzi
Published: July 2019

In the present study, we evaluate the serum level of common autoimmunologic markers in ‎women with polycystic ovary syndrome (PCOS) and study their relationship with ‎hormonal ‎parameters. The study was ‎an observational case-control study, done in a Tertiary referral hospital, the study ‎included ‎50 women with polycystic ovary syndrome and 50 matched control.‎ Serum levels of Antinuclear Antibody (ANA) and anti-double-stranded DNA (dsDNA) were significantly higher in polycystic ovary ‎syndrome women compared to control. Also, luteinizing hormone (LH), follicle stimulating hormone (FSH), and LH/FSH ratio were ‎significantly higher in polycystic ovary syndrome women compared to control. ‎dsDNA had excellent ability to differentiate PCOS from control (AUC=0.901) while ANA had good discrimination ability ‎‎(AUC=0.809). There was a significant direct relationship between ANA, dsDNA, and TSH ‎with FSH in PCOS women, ‏also a ‎significant direct relationship between ANA and TSH with LH, while ‎DsDNA did not correlate with LH. In conclusion, there is a clear relationship between immunological markers (ANA, dsDNA) with ‎‎polycystic ovary syndrome in various components of the disease, dsDNA offer better ability than ANA as a predictor of PCOS, indicating that dsDNA can be used as a non-invasive diagnostic tool for PCOS.
Study of the correlation between CA15-3 and each of prolactin hormone and lactate dehydrogenase enzyme in women with breast cancer in THI – QAR governorate – Iraq
Authors: Hadeel Rashid Faraj
Published: July 2019

The most malicious tumor in women is breast cancer. Its treatment at the early stage of its recognition in a woman provides her multiple options for diagnosis. Physical inspection and mammography are helpful screening processes for the primary recognition of breast cancer, they are also labor dependent and need health specialists who are exceptionally prepared and skilled. This experiment was designed to estimate and compare the CA15-3 level, hormone, and Lactate dehydrogenase enzyme in Breast Cancer patients and in apparently healthier individuals. Blood CA15-3, hormone, and Lactate dehydrogenase enzyme levels were determined in 65 Women with Breast Cancer and 55 apparently healthy subjects. The levels of serum CA15-3, hormone, and Lactate dehydrogenase enzyme were showing a significant increase in women with Breast Cancer in comparison to the control group (P ≤ 0.05). The study also investigates the correlation between the concentrations of the CA15-3 and each of hormone, and Lactate dehydrogenase enzyme, However, we compared all measurement parameters according to the type of disease. In Breast cancer patients, we increase CA15-3, hormone, and Lactate dehydrogenase enzyme can clearly occur, and we positive correlation relationship between CA15-3 and each of PRL and LDH through coefficient correlation (r).
The significance of uteroplacental ratio in the prediction of perinatal outcome in pregnancy-induced hypertension
Authors: Iman Allami M
Published: July 2019

Doppler investigations of placental and maternal flow have picked up a wide prominence as it could give significant data with respect to fetal prosperity and could be utilized to distinguish embryos in danger of bleakness and mortality, in this manner giving a chance to improve fetal results. In such manner, the accessible typical reference estimations of proportion () for example uterine corridor Doppler waveform parameters to those of umbilical course and impact of hypertension on Doppler waveform of the obstetric populace of various countries, were not unequivocally illustrated. The examination incorporates 60 pregnant ladies (in two periods 33-36 weeks and 37-40 weeks of incubation, 40 of them with pregnancy instigated hypertension and 20 as a control. The uterine courses and umbilical corridor files were determined just as proportions () for the RI and S/D, subsequent to gating the normal estimations of both uterine conduits files, the proportion between the uterine supply route and umbilical vein records was taken(normal uterine supply route/umbilical vein proportion, ). The mean ± SD of parameters expressed in the following manner:For PIH group At 33-36 weeks: RI =0.89 ± 0.26, PI = 0.94 ± 0.41and S/D =0.86 ± 0.31. The 95% confidence interval of the mean for four weeks were 0.77-1.0, 0.78-1.11, 0.74-0.99, respectively. At 37-40 weeks: RI= 1.00 ± 0.26, PI =1.05 ± 0.43 and S/D =1.03 ± 0.36. The 95% confidence interval of the mean for four weeks were 0..61, 0..31 and 0.81-1.25 respectively. For control group:At 33-36 weeks : RI =0.69 ± 0.08,PI= 0.73 ±0.13, and S/D=0.67 ± 0.09. The 95% confidence interval of the mean for four weeks were 0..80, 0..90 and0..78 respectively. At 37-40 weeks : RI= 0.99 ± 0.31, PI=0.95 ± 0.33, and S/D=0.92 ± 0.25. The 95% confidence interval of the mean for four weeks were 0..80, 0.76-1.13 and0.78-1.06respectively. A starter foundation of proportion ( of RI, PI and S/D) of Iraqi obstetric populace in and PIH at third trimester is most likely settled. The present investigation gave reference ranges in regards to uterine and umbilical supply routes , and S/ at 33-36 and 37-40 weeks of incubation in both.
Synthesis, characterization and pharmacological activity of new 2- imino –thiazolidine-4-one derivatives
Authors: Raghdah M. Alwiswasy  , Raheem Jameel M  , Basim Jasim Hameed
Published: July 2019

A new 2-iminothiazolidin-4-ones compound and its derivatives were synthesized and characterized by FT-IR, CHN, and 1HNMR techniques. The target compounds were assessed for their anti-inflammatory and analgesic activities, and the study was performed using Swiss albino mice (25-30 g) for investigation. A hind edema model caused by , while the analgesic activity was assessed using an acetic acid-induced writhing and a hot plate test evaluated the anti-inflammatory activity.
EFIKASI DIRI DALAM MEMBUAT KEPUTUSAN KARIER PADA MAHASISWA
Authors: Rahmi Fitria
Published: July 2019

Efikasi diri dalam membuat keputusan karier (Career Decision Making Self Efficacy/CDMSE) merupakan keyakinan individu bahwa dirinya dapat secara sukses melakukan tugas-tugas yang berkaitan dengan pengambilan keputusan karier. Fenomena yang terjadi saat ini masih banyak mahasiswa yang bingung dengan pekerjaan yang akan dipilihnya. Tidak sedikit yang kesulitan untuk membuat keputusan terhadap pilihan karier kedepannya. Hal ini tentu akan menghambat dalam mencapai tugas perkembangan karier mereka. Penelitian ini bertujuan untuk mengetahui bagaimana gambaran efikasi diri mahasiswa dalam membuat keputusan karier. Penelitian ini merupakan penelitian kuantitatif deskriptif. Data diperoleh dari 824 orang mahasiswa Universitas Andalas dengan menggunakan alat ukur CDMSE-Short Form (Betz, Klein & Taylor, 1996). Hasil penelitian diperoleh bahwa sebanyak 576 orang mahasiwa (69.90%) memiliki efikasi diri kategori sedang dalam membuat keputusan karier. Selanjutnya efikasi diri dalam membuat keputusan karier pada kategori tinggi dan rendah memiliki persentase yang hampir sama yaitu sebesar 14.93% dan 15.17%. Lebih lanjut hasil penelitian akan dibahas dalam diskusi penelitian.