bluuebunny/crossref_metadata_2025 huggingface dataset:
Aproximación a las habilidades blandas para la inserción profesional en ecosistemas creativos
Authors: Ávalos Rodríguez Ileana , Mariel Patzi Samantha , Bedregal Marzluf Jorge
Published: December 2021

La economía naranja es un sector atractivo para las nuevas generaciones de profesionales de América Latina y el Caribe, pues en los últimos 5 años ha generado cada vez más oportunidades laborales e ingresos a los países de la región. Diferentes estudios reportan la brecha entre las necesidades del mercado laboral y las habilidades que desarrollan los profesionales que buscan insertarse en el mismo. Los mismos indican que las habilidades blandas son necesarias para una inserción laboral exitosa. El sector económico dedicado a la innovación, creatividad y cultura, al representar un área en constante crecimiento, necesitará profesionales con habilidades que aún no se han identificado a través de estudios en la materia. En el presente artículo presenta una revisión bibliográfica que pretende definir las habilidades blandas prioritarias para que una persona profesional pueda insertarse en ecosistemas creativos con éxito.
Reflexión y aportes de una experiencia pedagógica en educación musical para la primera infancia, en el período de marzo a junio de 2020 durante la pandemia por COVID-19 en una institución educativa de Bogotá-Colombia
Authors: Padilla Rubiano Yudicebim María del Rosario
Published: December 2021

El presente artículo realiza un aporte a las metodologías virtuales en la enseñanza de música para la primera infancia, por medio de una reflexión de una experiencia educativa vivida en una institución maternal y preescolar de la ciudad de Bogotá (Colombia), con niños de cero a cinco años durante los meses de marzo a junio 2020, dentro del transcurso de la emergencia socio-sanitaria generada por la pandemia de la COVID-19 a nivel global. La experiencia docente refleja las impresiones frente a las estrategias pedagógicas aplicadas, presentando esta modalidad como alternativa para la enseñanza de la música. Las estrategias implementadas se desarrollaron con creatividad y resiliencia para alcanzar el objetivo inicial de diseñar estrategias metodológicas según los recursos disponibles en casa y las necesidades de las familias. El instrumento para sistematizar la experiencia fue un diario de campo donde la docente realizó la caracterización de las estrategias propuestas entre el mes de marzo a junio. Algunas de las dificultades evidenciadas en los procesos educativos estaban vinculadas a los horarios de clase y rutinas, la disponibilidad de tiempo de los padres para acompañar a sus hijos en los encuentros virtuales y el periodo de atención de los niños en la pantalla. Por otra parte, algunos de los hallazgos más significativos en esta experiencia fueron: la rápida adaptación de los niños de 3 a 5 años en el nuevo ambiente de aprendizaje y el desarrollo de nuevas estrategias metodológicas para motivar al educando en los encuentros virtuales.
Evaluate the Effect of Talc Versus Olive Oil Back Massage on Prevention of Pressure Sore Among Bedridden Patients Admitted in a Selected Hospital of Guwahati, Assam
Authors: Pathak Priyanka , Dutta Nabajani
Published: December 2021

Background: Pressure sores are injuries to skin and underlying tissues caused by prolong pressure. Talc and olive oil is a product with potential preventive effect to prevent bedsore because of its numerous medical properties. Objective: To estimate the effect of talc versus olive oil back massage on prevention of pressure sore among bedridden patients. Material and method: A quantitative research approach with factorial experimental design was used in this study. 50 patients were selected using convenient sampling technique and who fulfill the inclusion criteria of the study. Data was collected using self-administered questionnaires for demographic variables, Braden Scale for risk of pressure sore assessment and standard protocol on steps of back massage. Data was analyzed using descriptive and inferential statistics. Results: The comparison of effect of back massage with talc versus olive oil on prevention of pressure sore among Group I and Group II bedridden patients reveals that post-test mean score in Group I was 13.88±2.682 and posttest mean score in group II was 16.44±2.694 with mean difference of 2.56 which was tested by using unpaired t test with calculated value (t=3.367, df=48, p=0.002) was found to be statistically significant. As the mean is higher in group II (olive oil) than Group I (talc) hence it is considered that olive oil is more effective in preventing pressure sore than talc. Conclusion: The study concluded that the back massage with talc and olive oil was effective in prevention of pressure sore among bedridden patients.
Prevalence of Anxiety and Depression among Epileptic patients in selected Hospitals, Rohtak. Haryana
Authors: Vikash Vikash , Rajamani Sathish , Kumar Rajesh
Published: December 2021

Background: Epilepsy is a common neurological condition associated with recurrent and unpredictable seizures associated with significant psychological and social consequences. People with epilepsy (PWE) are more vulnerable to psychiatric illnesses: rates of psychiatric illness are 9% higher among PWE than in the general population and rates of depression, 22% higher. Aim of the Study: to assess the prevalence of anxiety and depression among epileptic patients. Methodology: Non-experimental descriptive survey research design was adopted in this study. data were collected from 100 outpatients who were visiting Vashishtha Neuro Care in City Rohtak, Haryana. Convenience sampling technique was adopted to recruit samples. Data were collected through GAD – 7 Spitzer et al., (2006) and Neurological Disorder Depression Inventory for Epilepsy. (NDDI – E) David E Friedman (2009), Collected data were analysed by means of descriptive and inferential statistics. Results: An overwhelming majority of the samples mild 72 (72.00%) have mild level of anxiety. Similarly, with regard to depression an overwhelming majority of the samples mild 54 (54.00%) have mild level of depression. High correlation was there between anxiety and depression (r = 0.785). There was a statistically significant association between anxiety and residence (ꭓ2 = 7.451, ‘P’ value 0.024). Statistically significant associations were also present between depression and the demographic variables such as past history of medical illness, substance abuse and hospitalization. Conclusion: Our study findings revealed anxiety was more than depression among clients with epilepsy. There was also high correlation among the comorbidities. More attention should be paid to incorporating anxiety and depression screening and treatment into existing epilepsy programs and to revising treatment guidelines of epileptic clients.
A Quasi Experimental Study to Evaluate the Efficacy of Sesame Oil on Radiation Induced Xerostomia among patients with Head and Neck Cancer
Authors: Suvitha R. , Kanchana K. , Nirmala T.
Published: December 2021

A quasi experimental study to evaluate the efficacy of sesame oil on radiation induced xerostomia among patients with head and neck cancer. Non randomized quasi experimental pretest posttest control group design was adopted in this study. By using purposive sampling technique, 26 samples were selected based on inclusion criteria, 13 in experimental and 13 in control group. The demographic variables, clinical profile of the samples were collected, the level of Xerostomia was assessed by modified GRIX questionnaire in both experimental and control group. Intervention was given to experimental group and routine treatment was given to control group. It was identified that the mean level of Xerostomia among head and neck cancer patient in the experimental and control group was 51.08 and 30.4 respectively with mean difference of 20.54. Likewise the standard deviation of the experimental and control group was 4.63 and 4.92 respectively. The calculated ‘t’ value 10.96 was greater than the table value of 2.06 at 0.05 level of significance. Hence, it was concluded that sesame oil mouth rinsing is an effective method to reduce the radiation induced Xerostomia among patient with head and neck cancer.
Level of stress and anxiety regarding Covid-19 among nursing students
Authors: Limugha Dominica , Lhingpineng Kipgen , Kaihe Leshiiro , N Nianlalkim , Mirita Toppo , Lilly Touthang , Cecilia Katasi
Published: December 2021

INTRODUCTION: COVID-19 pandemic has caused disasters and disorders all over the world. India is also going through a challenging situation as the number of infected/positive cases is increasing day by day. Due to the crisis of COVID-19 education system has come to a halt as schools and colleges are closed to slow down and prevent the spread of infection. Nursing institution also closed down and online mode of teaching was done. Hands on training is required to relate theory in to practice which was thwarted due to the pandemic COVID-19. Nursing students were panic and apprehensive about the situation even though they were asked to stay in the hostel. OBJECTIVE: To assess the level of stress and anxiety among the nursing students and to associate the level of stress and anxiety with selected demographic variables. METHODS: The study design was descriptive cross-sectional. The study was conducted in College of Nursing CIHSR among the 3rd Year GNM, 3rd Year and 4th Year B. Sc. Nursing Students. Total enumerative sampling method was used and sample size was 95. Standardized instrument on Perceived stress scale for assessing stress and Corona anxiety scale for assessing anxiety regarding COVID – 19 were used for the study. The study was approved by nursing research committee and informed consent was taken. Data was analysed using descriptive and inferential statistics. RESULTS: The study found that 80(84.2%) had moderate stress out of 95 respondents, 8 (8.4%) had high perceived stress, and 7(7.4%) had low level of stress. In the Coronavirus anxiety scale majority of the respondents, 91(95.8%) have little to no dysfunctional anxiety out of 95 respondents, 2 (2.1%) had possible dysfunctional anxiety and 2 (2.1%) had probable dysfunctional anxiety. There were no significant association between level of stress, anxiety and demographic variables. CONCLUSION: Study reveals that majority of the students had moderate level of stress and little to no dysfunctional anxiety regarding COVID - 19. Thus leaflet regarding cause, spread, prevention and management of COVID-19 given to each student to reduce their stress and anxiety.
Ý nghĩa của một số chỉ số xét nghiệm hồng cầu lưới trên lâm sàng
Authors: Nga Phạm Thị Thanh , Tùng Nguyễn Quang , Thành Nguyễn Chí
Published: December 2021

Hồng cầu lưới là các tế bào hồng cầu chưa trưởng thành. Chúng bắt nguồn từ tủy xương, biệt hóa rồi ra máu ngoại vi trở thành hồng cầu trưởng thành. Xét nghiệm số lượng, tỷ lệ hồng cầu lưới từ lâu đã được thực hiện để đánh giá chức năng, hoạt động của sinh hồng cầu. Xét nghiệm này không chỉ giúp đánh giá và phân loại thiếu máu mà còn giúp theo dõi sự phục hồi của tủy xương sau điều trị hóa chất hay ghép tủy… Gần đây, nhiều chỉ số khác của hồng cầu lưới như chỉ số lượng hemoglobin hồng cầu lưới (CHr), chỉ số trưởng thành hồng cầu lưới (IRF), nồng độ hemoglobin hồng cầu lưới (retHb), tỉ lệ trưởng thành hồng cầu lưới (RMI) được nghiên cứu với nhiều ý nghĩa trong chẩn đoán và điều trị thiếu máu. Bởi vậy, bài báo này nhằm giới thiệu về một số chỉ số xét nghiệm hồng cầu lưới và ý nghĩa của chúng trên lâm sàng.
Đánh giá kết quả phẫu thuật kết hợp xương bằng nẹp vít điều trị gãy kín mâm chày tại Bệnh viện Đại học Y Hà Nội
Authors: Thành Đào Xuân , Bounna Huonn , Hoạt Nguyễn Văn
Published: December 2021

Mục tiêu của nghiên cứu nhằm đánh giá kết quả phẫu thuật kết hợp xương bằng nẹp vít cho những bệnh nhân gãy kín mâm chày tại Bệnh viện Đại học Y Hà Nội. Thiết kế nghiên cứu được sử dụng là nghiên cứu mô tả  trên 33 bệnh nhân gãy mâm chày được phẫu thuật kết hợp xương bằng nẹp vít tại Bệnh viện Đại học Y Hà Nội, thời gian từ tháng 01/2019 đến tháng 02/2021. Kết quả nghiên cứu cho thấy trên các bệnh nhân gãy mâm chày được phẫu thuật kết hợp xương bằng nẹp vít, tuổi trung bình 44,4 ± 14,3, thấp nhất 17 tuổi, cao nhất 81 tuổi, độ tuổi hay gặp nhất là từ 20 - 40 tuổi (48,5%). Có 32/33 bệnh nhân liền vết mổ thì đầu (96,96%), chỉ có 01/33 bệnh nhân liền vết mổ muộn; đa phần bệnh nhân có kết quả sau mổ tốt: 19/33 bệnh nhân ổ gãy khít (57,58%) và không lún (57,58%), 31/33 bệnh nhân không có lệch trục hoặc lệch trục < 10°. Tuy nhiên cũng có một số bệnh nhân vẫn có lún ≤ 5mm (42,42%) và có 2 bệnh nhân có lệch trục > 10° (6,06%); tỷ lệ bệnh nhân có kết quả X-quang rất tốt theo Rasmusen ở độ I, II, III, IV cao hơn so với độ V, VI (p < 0,05). Chức năng sau mổ theo thang điểm IKDC, kết quả rất tốt: 45,5%, tốt: 30,3%, trung bình: 18,2%, chỉ có 6% có kết quả kém. Tỷ lệ bệnh nhân có kết quả rất tốt theo chức năng IKDC ở độ I, II, III, IV cao hơn so với độ V, VI, (p < 0,05). Phẫu thuật kết hợp xương bằng nẹp vít là phương pháp điều trị hiệu quả cho những bệnh nhân gãy kín mâm chày.
Kết quả điều trị sau phẫu thuật ở bệnh nhân thoát vị đĩa đệm cột sống thắt lưng cùng có hẹp ống sống bằng phương pháp cố định cột sống qua cuống và ghép xương liên thân đốt qua lỗ liên hợp (xâm lấn tối thiểu và mổ mở)
Authors: Hùng Kiều Đình , Sơn Bùi Văn
Published: December 2021

Phẫu thuật xâm lấn tối thiểu TLIF (Mis-TLIF) ngày càng được sử dụng nhiều trong các bệnh thoát vị đĩa đệm cột sống thắt lưng cùng có hẹp ống sống. Mục tiêu nghiên cứu của chúng tôi nhằm đánh giá kết quả lâm sàng của phẫu thuật xâm lấn tối thiểu (Mis) và phẫu thuật mổ mở có hàn xương liên thân đốt qua lỗ liên hợp (TLIF). Phương pháp nghiên cứu mô tả, hồi cứu được thực hiện từ tháng 1 năm 2020 tới tháng 12 năm 2020 trên 83 bệnh nhân được phẫu thuật tại Bệnh viện Đại học Y Hà Nội. Độ tuổi trung bình của các bệnh nhân là 49,31 ± 12,83 tuổi, trong đó tỉ lệ Nam/Nữ là 1,01/1. So với những bệnh nhân được mổ mở TLIF, bệnh nhân được mổ theo phương pháp xâm lấn tối thiểu TLIF có lượng máu mất trong mổ, thời gian nằm viện sau mổ ít hơn hẳn (P < 0,05), thời gian phẫu thuật của nhóm xâm lấn tối thiểu TLIF cũng ngắn hơn. Hơn nữa, tình trạng đau lưng sau mổ 6 tháng ở nhóm mổ xâm lấn tối thiểu TLIF cũng ít hơn hẳn nhóm mổ mở TLIF. Tình trạng đau chân, điểm chức năng cột sống ODI sau mổ thấp hơn ở nhóm mổ xâm lấn tối thiểu TLIF tuy nhiên sự khác biệt là không có ý nghĩa thống kê. Phẫu thuật xâm lấn tối thiểu TLIF ở các bệnh nhân thoát vị đĩa đệm cột sống thắt lưng cùng có hẹp ống sống thực sự an toàn và có lợi ích nhiều hơn so với mổ mở TLIF.
Nghiên cứu giá trị của xét nghiệm Xpert MTB/RIF Ultra đờm ở người bệnh nghi lao có hai mẫu xét nghiệm soi đờm trực tiếp AFB (-)
Authors: Cương Nguyễn Kim , Hoàng Nguyễn Huy
Published: December 2021

Những trường hợp có hai mẫu đờm âm tính chẩn đoán lao phổi AFB (-) chiếm khoảng 23% các trường hợp chẩn đoán lao phổi. Số lượng này có xu hướng tăng dần do việc phát hiện bệnh lao sớm và điều trị hiệu quả. Xét nghiệm Xpert MBT/RIF Ultra là thế hệ xét nghiệm Xpert MTB thứ 4, có độ nhậy cao hơn. Nghiên cứu nhằm mô tả đặc điểm lâm sàng, cận lâm sàng và xác định giá trị xét nghiệm Xpert MTB/RIF Ultra đờm trong chẩn đoán lao phổi ở người bệnh có hai mẫu đờm AFB âm tính. Nghiên cứu mô tả cắt ngang so sánh được thực hiện trên 201 người bệnh nghi lao có hai mẫu đờm AFB âm tính. Nghiên cứu cho thấy tỉ lệ nam giới: 67,7%, nhóm tuổi 40 - 64 chiếm tỉ lệ cao nhất 51,2%, nghề nghiệp tự do chiếm 39,8%. Lý do vào viện chủ yếu là ho chiếm 60,2%. 49,3% người bệnh có sốt chủ yếu là sốt nhẹ chiếm 77,8%. Trên CLVT ngực, tổn thương nốt chiếm tỉ lệ cao nhất 62,2%, nhóm tổn thương kính mờ trên CLVT ngực có MGIT (+) cao gấp 2,27 lần có ý nghĩa thống kê với p = 0,041. Độ nhạy của Xpert MTB/RIF Ultra so với MGIT đờm là Se 83,3% (50/60), độ đặc hiệu là Sp 95,7% (135/141), giá trị dự báo dương tính PPV là 89,3% (50/56), giá trị dự báo âm tính là NPV 93,1% (135/145). Độ nhạy của Xpert MTB/RIF Ultra dạng vết so với MGIT đờm là 30% (3/10), độ đặc hiệu là 91,9% (124/135), giá trị dự báo dương tính là 21,4% (3/14), giá trị dự báo âm tính là 94,7% (124/131). Xét nghiệm Xpert MTB/RIF Ultra đờm có độ nhạy, độ đặc hiệu cao trong chẩn đoán lao phổi AFB âm tính.
Tăng Acid uric máu không triệu chứng và một số yếu tố liên quan ở nam giới đến khám tại Bệnh viện Đại học Y Hà Nội
Authors: Tú Phạm Văn , Hằng Phạm Thu , Trang Đỗ Thị Huyền , Giang Trần Thu , Thoa Nguyễn Thị , Thu Phạm Hoài
Published: December 2021

Mục tiêu của nghiên cứu nhằm nhận xét tình trạng tăng acid uric máu không triệu chứng và một số yếu tố liên quan ở nam giới đến khám tại Bệnh viện Đại học Y Hà Nội với 798 nam giới từ 18 tuổi trở lên từ tháng 1 năm 2020 đến tháng 5 năm 2021. Thiết kế nghiên cứu mô tả cắt ngang. Kết quả nghiên cứu cho thấy tỷ lệ tăng acid uric máu không triệu chứng là 41,4%, nồng độ acid uric máu trung bình là 405,2 ± 81,2 µmol/l (cao nhất là 820 µmol/l ), hay gặp nhất ở nhóm từ 40 đến 59 tuổi (chiếm 48,3%). Uống rượu bia, tăng huyết áp, thừa cân/ béo phì, rối loạn lipid máu là yếu tố nguy cơ gây tăng acid uric máu (p < 0,05). Có mối tương quan đồng biến giữa nồng độ acid uric máu với nồng độ Cholesterol toàn phần, Triglycerid máu (p < 0,05). Tình trạng tăng acid uric máu không triệu chứng ở nam giới có xu hướng tăng cao, đặc biệt ở những người có rối loạn lipid máu, tăng huyết áp và có sử dụng rượu bia.
Pissing it away
Authors:   Simon Chapple, Joy Mike
Published: December 2021

If you want to know why swimming in rivers of New Zealand is a bad idea, or why our groundwater is less safe for drinking than it was three decades ago, blame that cow and her many, many friends.
Association of Customer Satisfaction with Store Environment A Study on Bhat-Bhateni Super Market and Departmental Store
Authors: Maharjan Sarita
Published: December 2021

This paper aims at analyzing the relationships between store environment and customer satisfaction of Bhat-Bhateni Supermarket and Department Store. Descriptive and analytical research designs were used in this study. Judgemental sampling technique was used to collect opinion survey data through structured questionnaire. Out of 150 questionnaires distributed to customers of Bhatbhateni Super Stores under Bhat-Bhateni Supermarket and Department Store in Kathmandu valley, only 60.61 percent of them were found practical. Compare mean test and Gamma test are used to analyse the association between customer satisfaction and store environment at Bhabhateni Super Stores. Compare means test shows that only customers’ perceptions on employees of Bhatbhateni Super Stores are different by gender. Gamma coefficients show that customer satisfaction has a significant positive association with music, lighting, assortment, interior design and employees except layout. Store environment plays an important role in business. Friendly store environment could be a good factor for supermarket to enhance customers’ satisfaction level.

Keywords: Store environment, Customer satisfaction, Supermarket
Caretaking Aboriginal Australian Knowledges Online
Authors: Kutay Cat
Published: December 2021

The influence of Aboriginal Australian's Knowledges and Protocols on Australian culture has been profound and yet little acknowledged. To acknowledge the First Peoples of Australia and integrate their knowledge into the education system, we start with the First Peoples' contribution to culture and learning since invasion in Australia. We then consider contributions now to educational technologies with a focus on collectivist knowledge sharing, oral teaching, narrative teaching, peer-to-peer sharing, and truth telling. In recognition of what modern non-Indigenous cultures have lost, we are appropriating technology to share the concepts around narrative learning and sustainable practice. This uses pattern matching skills that were initially developed for sharing knowledge across different environments between Aboriginal Australian communities and provides processes for memorizing and sharing diversity. Ways of emulating these processes online is constructive in modern language reclamation, where the existing language information is scattered across many individuals, clans, and locations.
Narratives of Social and Emotional Well-Being: Online Teamwork During COVID-19 Lockdown
Authors: Daniels-Mayes Sheelagh , Thambyrajah Janette , Troy Jakelin , Torwali Mujahid , Gilroy John , Bhatti Adnan , Talbot Folau
Published: December 2021

The year 2020 will always be remembered for COVID-19. The global pandemic has brought massive disruption to our everyday lives on many fronts—lockdowns, economic disaster, border closures, and an unprecedented uptake of online human engagement. Workplaces rose to the challenges of adapting to fully online environments. For some, this has been a smooth transition, but for others this change of work mode has brought high levels of stress, disconnectedness, dissatisfaction, and exacerbated isolation. Arguably, for those more vulnerable and marginalized peoples, there is a greater risk of negative outcomes than for those who are affiliated with the dominant society. In this article we share stories gathered from members of the Sydney Indigenous Research Hub of The University of Sydney. By applying the qualitative methodology of narrative enquiry to our shared stories, we will show how we have used online platforms to support and care for one another's individual and collective social and emotional well-being according to Indigenous ways of understanding.
Clinical prognosis of Charles Bonnet Syndrome: A review of Integrative Literature
Authors: Santos Trinnye Luizze , Oliveira Paula Drumond Batista de , Oliveira Maria Paula Travasso , Morais Gustavo Henrique Duarte de , Fortes Bruna Carolina Rangel , Rizzardi Darina Andrade Addario , Guerreiro Milena Gonçalves , Matos Silvia Regina Seibel De , Marques Milena
Published: December 2021

Background: Charles Bonnet syndrome (CBS) is defined by repetitive experiences of visual hallucinations. This classically affects the elderly with visual impairment, intact cognition and the absence of psychiatric illness. Hallucinations remain indefinitely and can be static, dynamic, elementary or complex, colored or in black and white, centrally or peripherally. Objectives: To analyze the scientific information available on the clinical aspects of CBS. Methods: A bibliographic review was carried out in the PubMed database, in the last 10 years, using the descriptors “Charles Bonnet Syndrome”, “Hallucinations” and “Prognosis”, associated with the Boolean operator “AND’’. English and Portuguese were included, inconclusive studies were excluded, with biases or duplicates, whose approaches did not indicate an outcome in the syndrome, selecting 12 articles. Results: It was observed that there is no consensus on the pathophysiology and age range of CBS involvement, which varies between 70 and 80. The incidence is up to 1.4%. As for the prognosis, one of the articles pointed to the presence of hallucinations between 7 and 18 months, these varying in complexity, frequency and impact on patients’ lives. Diagnosis is made by exclusion, emphasizing the benign character, assertive diagnosis and effective treatment are essential factors for the mild evolution of the disorder. Conclusion: As it is considered a rare disease, it is rarely addressed in the literature and, therefore, new studies are desirable, in order to demystify the condition and ensure an appropriate approach to patients.
Neurodegeneration with cerebral iron accumulation: a case report
Authors: Saito Monalisa Moura , Lacerda Dhyego Ferreira Moreira de , Melo Ana Claudia Marque Gouveia de , Nunes Lucas Monteiro Barros , Costa Luana Cristina Rodrigues de Oliveira , Gomes Eduarda Silvestre Ribeiro da Costa
Published: December 2021

Introduction: NBIA is a rare disease, with a prevalence of 1/1,000,000.It is characterized by abnormal iron accumulation. Clinical findings may include progressive extrapyramidal disorders, involvement of the pyramidal, peripheral, autonomic nervous systems, superior cortical, visual and cerebellar functions. The diagnosis is made through the association of clinical findings and complementary exams. Currently, the treatment is only symptomatic, with no specific therapy. Case report: 5-year-old female, reporting involuntary movements and difficulty walking a day ago. Presented agitation and delayed neuropsychomotor development, seen since 1 year of age. On examination, dysarthria, dystonia and parkinsonian stiffness were observed. MRI of the brain showed the radiological signal “tiger’s eye” and the ophthalmological evaluation showed retinal dystrophy. Positive acanthocyte screening. NBIA’s NGS panel confirmed the diagnosis. Triexfenid was started and there was an improvement in movement disorders. In outpatient follow-up, the symptoms worsened. Levodopa was associated with the return of walking without support and ability to pick up objects. Discussion: In this case, Triexafenid 2mg/day was initially prescribed, with a slight improvement in movement disorders. Levodopa was started with the aim of improving symptoms of parkinsonian stiffness. The excellent response to the association of the drug in low doses stands out, enabling ambulation and functionality for daily activities. Conclusion: NBIA is a rare disease, with rapid onset and progression. Studies show limited benefits of levodopa in the case of PKAN. We emphasize significant clinical improvement, with a return to walking after administration of the drug.
Association between obstructive sleep apnea and ischemic stroke etiology
Authors: Torquato Ana Claudia Crispiniano Siqueira , Santos Silvana Sobreira , Pedrosa Rodrigo Pinto
Published: December 2021

Introduction: Stroke is a potentially disabling event, therefore determining its etiology is the key in the development of management strategies to reduce the risk of a new event and costs. Obstructive sleep apnea (OSA) is common in stroke and is an independent risk factor. The objective of this study was to determine the association between the etiology of ischemic stroke and the presence of OSA. Methods: Observational, descriptive, patients with ischemic stroke or acute transient ischemic attack (TIA) in the Hospital Memorial São José and Hospital Esperança Recife-PE for one year, the etiology of stroke was categorized by TOAST classification and portable polysomnography for diagnosis of OSA. Results: 100 patients analyzed, 81 ischemic strokes and 19 TIA. The prevalence OSA (AHI≥15) was 51%. The mean age of the sample was 67.9±14.6 years, with older OSA patients (70.0±14.2 vs 65.6±14.7, p=0.128). There was a higher occurrence of females, DM, dyslipidemia and previous ictus in patients with OSA (p=0.052 /0.008 /0.055 /0.018, respectively). BMI was 27.22±4.3kg/m² in patients without OSA and 28.05±3.8kg/m² among patients with OSA. There was no association between the etiological subtype of ictus and the presence of OSA (p=0.698). Conclusions: Our study included an elderly population with a higher frequency of dyslipidemia, DM and previous ictus in patients with OSA, but it was not possible to establish a relationship between the etiology of the stroke and the presence of OSA.
Charcot arthropathy in the elbow caused by hydrosiringomyelia
Authors: Marin Carolina Maria , Costa Gustavo Carvalho , Souto Emilia Correa , Pinto Icaro França Navarro , Farias Igor Braga , Badia Bruno de Mattos Lombardi , Machado Roberta Ismael Lacerda , Souza Paulo Victor Sgobbi , Pinto Wladimir Bocca Vieira de Rezende , Oliveira Acary Souza Bulle
Published: December 2021

Introduction: Syringomyelia is a chronic disease of the spinal cord that leads to damage to nerve fibers in the spinothalamic tract. The changes in these structures responsible for the thermal and painful sensitivity lead to an abnormal innervation of the joints, which can lead to neuropathic arthropathy, called Charcot arthropathy. Syringomyelia is the main cause of Charcot arthropathy in the upper limbs, and the most involving joints are the shoulder and elbow. It is a rare condition and its recognition allows for early diagnosis and proper management. Case report: A 50-year-old female patient, with a previous history of spinal cord trauma, who has been in a wheelchair since then, started with edema in the left upper limb, mainly in the elbow, evolved with local ulcer and presence of serosanguinolent secretion, weakness and paresthesia in the left hand. Magnetic resonance imaging of the elbow showed signs of neuroarthropathy and the study of the thoracic cervical spine showed enlargement of the cerebrospinal fluid space and tapering of the spinal cord. Conclusions: Charcot’s arthropathy should be considered as a differential diagnosis of pain, edema and limitation of joint movements. When present in the upper limbs, an investigation should be carried out to exclude syringomyelia.
Traumatic brain injury from ground level fall in the elderly: a systematic review
Authors: Rodrigues Luiz Ricardo Avelino , Vasconcelos Ana Elisa Chves de , Rodrigues Matheus Duarte , Sobrinho Tobias Mosart , Horta Wagner Gonçalves
Published: December 2021

Background: Traumatic Brain Injury (TBI) is an anatomical or functional injury that affects the skull or brain and other associated structures. When analyzing the occurrence of TBI in the geriatric population, Ground Level Fall (GLF) is the main mechanism of trauma. Objectives: To understand the scenario of TBI from GLF in the elderly, characterizing it, in order to point out associated factors and its consequences. Desing and setting: Systematic review at the University of Pernambuco in Recife city. Methods: This is a systematic review of articles indexed in the MEDLINE/ Pubmed, LILACS, BDENF and BINACIS databases and two other works from Google Scholar in April 2021. Original articles in Portuguese and English that met the objectives of this review and were published in the last ten years (2011-2021) were included. Results: Four articles were included. The mean age of elderly who developed TBI from GLF was around 80 years, with a higher prevalence in females. In ad- dition, it was observed that most victims already had associated comorbidities and medications, such as anticoagulants, antiplatelet agents and antiarrhythmic agents. Patients had an average length of hospital stay from 2 to 7.7 days. Limbs and Face injuries were observed. Conclusions: TBI from GLF in the elderly is frequent and even though the length of hospital stay and deaths related to this trauma were low, physical and psychological consequences are also associated to this injury. Clinical Trial or Systematic Review Registration: 254698, https://www.crd.york. ac.uk/prospero/
Morvan’s syndrome: case report
Authors: Lima Thaís Neves , Santos Eustáquio Claret dos , Dorim Diego Dias Ramos , Sion Gisele Novaes Matias , Ferraz Pedro Henrique da Silva
Published: December 2021

Introduction: Morvan’s syndrome is a rare neurological condition characterized by the combination of central and peripheral symptoms such as neuromyotonia by fasciculation, dysautonomy and encephalopathy associated with laboratory evidence of the VGKC antibodies LGI1 and CASPR2. Case report: A 77-year-old man was admitted to the emergency room with a 3-month history of mental confusion, alteration in memory and language, visual and auditory hallucinations, and seizures. He had a sudden decrease level of consciousness and generalized myoclonus, being admitted to the intensive care unit. Due to non-improvement of the neurological condition, the possibility of encephalitis rose, herpes simplex virus (HSV) polymerase chain reaction (PCR) and 14.3.3 protein in cerebrospinal fluid (CSF) were performed, which resulted negative later. Analysis of CSF showed a high level of protein and cells. Magnetic resonance imaging (MRI) of the brain showed hypersignal activity in the bilateral internal capsule, temporal and frontal region. An extensive propaedeutic was performed for rapidly progressive dementia, including an autoimmune panel, with anti-glioma rich in inactivated leucine 1 (LGI-1) positive by indirect immunofluorescence. Discussion: the diagnosis of Morvan’s Syndrome is clinical. Some cases are reported with spontaneous remission and others that require extensive treatment, with immunotherapy, including plasmapheresis and immunosuppression. VGKC antibodies have been reported in association with three main clinical syndromes: neuromyotonia, Morvan’s syndrome and limbic encephalitis.
Fístula liquórica cervical ventral simulando doença do neurônio motor: relato de caso
Authors: Serrano Paulo de Lima , Frota Paulo Sousa , Farias Igor Braga , Badia Bruno de Mattos Lombardi , Albuquerque Filho José Marcos Vieira de , Souza Paulo Victor Sgobbi de , Pinto Wladimir Bocca Vieira de Rezende , Marussi Victor Hugo Rocha , Oliveira Acary Souza Bulle
Published: December 2021

Introduction: Motor neuron disease is currently irreversible, and the grave implications of the diagnosis should raise concerns over missing a potencial mimic disorder. The cervical region should be carefully evaluated, since many pitfalls are encounterd there. We present a case of a longitudinal extensive ventral cervical cecerebrospinal fluid leak causing a progressive monomelic amyothrophy associated with intracranial hypotension, mimicking a motor neuron disorder. Objective: To describe the course, clinical manifestations and to raise concern about a rare disorder, potentially treatable that could mimic a motor neuron disease. Methods: A case report seen in the neuromuscular service of the federal university of São Paulo.SP. Results: Cervical pain irradiating to the left shoulder was the first symptom. Pogression to weakness of the bíceps and shoulder girdle with fasciculations happened months after. The patient also complained about severe headache worsening when lowering the head or lyind down. Eletroneuromiography showed chronic denervation. Magnetic ressonance imaging of the cervical spine demonstrated ventral dural displacement with longitudinal extensive cerebrospinal fluid colection. Epidural blood patch procedure was indicated. After the treatment the patient showed complete improvement of the headache, significant decrease in fasciculations and evolutionary strength improvement. Conclusion: We described a rare form of amyothrophy that could be associated or not with intracranial hypotension. Ventral cervical cerebralpinal fluid leak should always be on the list of differential diagnosis and early indentification should be sought, since its a treatable cause.
Acquired copper deficiency myeloneuropathy with resolution Only after reversion of Roux-en-Y gastrojejunostomy: a case report
Authors: Serrano Paulo de Lima , Farias Igor Braga , Badia Bruno de Mattos Lombardi , Albuquerque Filho José Marcos Vieira de , Souza Paulo Victor Sgobbi de , Pinto Wladimir Bocca Vieira de Rezende , Marussi Victor Hugo Rocha , Oliveira Acary Souza Bulle
Published: December 2021

Introduction: The performance of bariatric surgeries has increased in recente years. Secondary mal- absorptive syndrome is an important cause of acquired copper deficiency, especially after Roux-em-Y gastric by-pass. The clinical manifestation of this deficiency disorder can occur years or decades after the surgery. Objective: To describe the course, clinical manifestations, therapeutic approaches and to raise concern about acquired copper deficiency in patients who underwent bariatric surgery. Methods: A case report seen in the neuromuscular service of the federal university of São Paulo.SP. Results: The patient underwent Roux-en-Y gastrojejunostomy in 2010, 6 years before the initial manifestations of paresthesia on the lower limbs and anemia. The symptons progressed to imbalance and falls. Magnetic resonance image depicted T2 hyperintense signal in the posterior column from C4- T4. A Vitamin B12 deficiency was considered to be the cause but intramuscular therapy was ineffective. The neurological condition deteriorated and the patient was unable to walk without a walker. A severe copper deficiency was diagnosed but oral and intravenous replacement did not improve the clinical picture. Only after reversion of the Roux-em-Y gastric by-pass that the patient improved. Conclusion: Obesity is growing health problem and the incidence of bariatric surgery is increasing. Acquire copper deficiency should always be on mind when facing a patient with myeloneuropathy that underwent these group of surgeries. Rapidly installed therapeutic approach can prevent neurological sequelae.
Suspected neurological disease associated with yellow fever vaccine: a series of 5 cases
Authors: Serrano Paulo de Lima , Belezia Anderson Benine , Farias Igor Braga , Badia Bruno de Mattos Lombardi , Albuquerque Filho José Marcos Vieira de , Souza Paulo Victor Sgobbi de , Pinto Wladimir Bocca Vieira de Rezende , Oliveira Acary Souza Bulle
Published: December 2021

Introduction: Yellow fever vaccine is avaible since 1930. Adverse reactions are mild, including headache, myalgia, fever and skin reaction on the site of application. Neurotropic disease is rare, more common in males and mainly in the first 30 days after vaccination. We report a series of 5 cases where vaccination initiated neurological manifestations. Objective: To demonstrate the variety of possible neurological complications and clinical course associated with yellow fever vaccination seen in our hospital. Methods: A case series of 5 patients seen in the neuromuscular service of the federal university of São Paulo.SP. Results: Most of our patients began symptons in the first 30 days after vaccination. 3 out of 5 patients where male, 2 cases described demyelinating diseases, 2 cases demonstrade cerebellar manifestations and 1 case of inflamatory polyneuropathy. Recovery was variable after treatment employed. Conclusion: Neurological complications are rare and can presente itself in several ways. Occurs manly in the first month with varying outcomes. It is essencial to ask the patient about vaccination, onset of symptons to associate cause and effect.
Tensional headache in medicine graduation
Authors: Bezerra Paulo Victor Protásio , Fonseca Gustavo Soares Gomes Barros , Machado Maria Luiza Mendes , Schmitt Natália Murad , Sauaia Filho Euler Nicolau
Published: December 2021

Introduction: Tension headache has become a major health problem for medical students. This can trigger a worsening in the quality of life of the student and hinder their learning, corroborating for an impaired education. Better understanding of the topic is necessary so the academics can have a better overview of the problem. Objective: Clarify the relationship between tension headache and the quality of life of medical students. Methods: Articles from the last ten years were selected on the Scielo and Google Scholar portal platforms, which made it possible through an online scenario. Results: The mechanisms of tension headache are controversial and their pathophysiology complex and poorly understood. In crises, analgesics, antiinflammatories, muscle relaxants and/or caffeine are applied. In the articles studied, epidemiological data suggest that most students (99%) have already had a headache case during their lifetime and such occurrences are related to moments of stress and tiredness (74%). It is visible, that the academic affected by various activities, is a target for the disease. Conclusion: The prevalence of tension headache in the medical student was higher than that of the general population, with stress as the main reason. then a resolution on the issue of pain regarding stress is necessary since it proved to be inappropriate.
Epidemiological analysis, risk factors and therapeutic plan for post-stroke depression
Authors: Innocencio Giovanna de Camargo , Hernandes Júnior Paulo Roberto , Lopes Patrick de Abreu Cunha , Rosa Juliana de Souza , Feitosa Jhoney Francieis
Published: December 2021

Background: the stroke is defined by the OMS as the rapid development of neurological symptoms and/or focal signs that last for more than 24 hours, resulting from the sudden change in blood flow to the region. Major depressive disorder is one of the main complications that exist after a stroke. Objectives to correlate the occurrence of depression and stroke, to analyze the risk factors and the best therapeutic approach for the condition. Methods: a literature review was carried out from the Scielo and PubMed database, using as descriptors “Stroke”, “Depression” and “Post-stroke depression”, where 13 articles between 2003 and 2018 were selected. Results: the major depressive disorder is the most common psychiatric complication after strokes. A meta-analysis identified a cumulative incidence of depression from 29% to 52% in the first five years after stroke, although several studies have shown that post-stroke depression is diagnosed in only 10% of cases. When not diagnosed or treated, it is associated with a reduction in the patient’s active participation in the rehabilitation process, a decrease in quality of life and an increase in mortality. Risk factors include previous functional and cognitive impairment, history of depressive disorder, sex, age, previous stroke, hypercortisolemia, poor social support network, neuroanatomical characteristics of the stroke and high serum levels of IL-6. The pharmacological management can be carried out prophylactically or therapeutically, with selective serotonin reuptake inhibitors being the most indicated and tricyclic antidepressants as an alternative. Conclusion: the frequency of depressive disorder after stroke is relatively high and characterized as a predictor of poor prognosis. The importance of attention to the multifactorial context in which depression arises and the early treatment of psychiatric comorbidities in post-stroke individuals should be reinforced, since this strategy may reflect on better quality of life and reduction in morbidity and mortality rates that occur after the condition.
Music therapy as treatment of Autism Spectrum Disorder: Systematic Review
Authors: Oliveira Paloma Abrantes de , Oliveira Maria Eduarda Duarte de , Souza Petrina Rezende de , Silva Rafaela Duarte , Silva Ronald Godinho de Oliveira , Pereira Taynara Caroline , Freitas Isabelle Magalhães Guedes
Published: December 2021

Introduction: Autistic Spectrum Disorder (ASD) is a neurodevelopmental disorder that affects social communication1 .Music is great for individuals with ASD, because it interacts with the brain, contributing with cognitive and psychosocial benefits2,3. Furthermore, music is emotional and promotes movement synchronization, being a non-pharmacological option for the treatment of ASD3 . Objective: To investigate the positive impacts of using music therapy for cognition in patients with ASD. Methodology: Controlled and randomized clinical trials, in English, performed on humans, in the last 5 years, indexed on PubMed, were selected from the descriptors “autism spectrum disorder” and “music therapy”. This review was registered on PROSPERO by protocol 254495 and the PRISMA recommendation was used to improve its organization. Results: Music therapy was efficient in improving the symptoms of children with ASD, because of the better sensitivity of individuals to music than words4 . In addition, music is able to restore brain connectivity, which is altered in TEA5 . Musical and emotional attunement allows synchronization, integrating the senses and affective regulation, improving self-awareness6. During therapy, there was a reduction in the diagnostic scale of ASD, indicating an improvement in communicative and social skills. Furthermore, it was noted that children became more socially responsive, but there were differences, suggesting the need to balance individual and methodological treatment7 . Finally, music therapy contributes to children’s well-being and health8,9. Conclusion: Evidence suggests that patients with ASD can benefit from music therapy, as it explores and expands the physical and mental limits of the autistic person, stimulating agility, communication and motor control.
Susac syndrome. Case report.
Authors: Brooks Joseph Bruno Bidin , Prosdócimi Fábio César , Kazama Gabriela Yumie Mota , Carvalho Thayná Emily Barboza de
Published: December 2021

Context: Susac Syndrome, was first described in 1979, by neurologist John Susac, and is characterized by a clinical triad consisting of: central nervous system dysfunction, visual changes and sensorineural hearing loss. Although the pathophysiology is not yet fully understood, the description occurs with microangiopathy involving arteries of the brain, retina and cochlea. The manifestation of the clinical triad has a monophasic and self-limiting course.This case report was approved by the Ethics Committee of Universidade Metropolitana de Santos. Case Report: The present case refers to a female patient, 40 years old, caucasian, and presented a sudden decrease in the visual acuity of the left eye, with visual blurring and dyschromatopsia. After 3 days, he sought medical assistance from an ophthalmologist, already presenting amaurosis of his left eye. Occlusion of distal branches of the retinal artery of the left eye was confirmed. He had a personal history of recurrent major depression and obsessive-compulsive disorder with sub-optimal response to drug treatment. Evaluated with neurology, referring to a decrease in asymmetric auditory acuity. Bilateral sensorineural hearing loss confirmed. Skull MRI was performed and showed multiple images of central lesions in the corpus callosum (“snow ball lesions”), as well as lesions in the white matter of the brain. Conclusions: The diagnosis of Susac syndrome was established and symptomatic treatment was performed, presenting with clinical stabilization.
Sporadic Creutzfeldt-Jakob disease. Case report
Authors: Brooks Joseph Bruno Bidin , Prosdócimi Fábio César , Covolan Fernanda Stoffel , Holanda Iane Rocha , Lucena Amanda Medeiros de , Macedo Eduarda Mendes Prado , Albero Bianca Angerami de Souza , Guimaraes Lucas Veiga
Published: December 2021

Context: Creutzfeldt-Jakob disease (CJD) is a rare disease that belongs to the category of transmissible spongiform encephalopathies. The condition is invariably fatal and progresses with severe dementia with psychiatric signs and, with cortical, subcortical and cerebellar signs. This case report was approved by the Ethics Committee of Universidade Metropolitana de Santos. Case Report: We present the case of a 59-year-old male patient who presented with a subacute onset of behavioral changes associated with myoclonus and changes in coordination. Associated with the described symptoms, he presented aphasia of expression, cerebellar incoordination and spasticity was also present in the four limbs. Conclusions: The usual forms of transmission could not be confirmed for this patient, who died four months after the onset of symptoms.
Villaret’s syndrome after ionizing radiation in the adjuvant treatment of lung malignancy. Case report.
Authors: Brooks Joseph Bruno Bidin , Prosdócimi Fábio César , Nader Guilherme Ribeiro , Antiqueira Letícia Chimini
Published: December 2021

Context: Villaret’s syndrome is characterized by neuronal dysfunction in the posterior retroparotid space, where the external carotid arteries, internal jugular veins, the cervical sympathetic trunk and the following cranial pairs IX, X, XI, XII pass. Symptoms may vary depending on the location and extent of the lesions. This case report was approved by the Ethics Committee of Universidade Metropolitana de Santos. Case Report: The present case refers to a female patient, 54 years old, who presented with an insidious and progressive onset of dysphagia, dysphonia and ageusia during adjuvant radiotherapy treatment for malignant lung cancer. The neurological examination showed miosis with ptosis and enophthalmos, weakness of the trapezius and sternocleidomastoid muscles, palate paresis and atrophy of the right tongue. Clinical diagnosis of Villaret Syndrome was performed. Complementary and imaging tests were normal. Villaret’s syndrome presents a variety of nosological entities, the most common being neoplastic and involving the posterior retroparotid space. Other causes such as vascular, infectious, immunomediated are described. The patient in question has a probable etiology by ionizing radiation in a structure close to the posterior retroparotid space. Conclusions: After 6 months of radiotherapy and symptomatic treatment, she presented with clinical stabilization.