bluuebunny/crossref_metadata_2025 huggingface dataset:
UTILIZAÇÃO DA CANNABIS SATIVA PARA TRATAMENTO DE DOR CRÔNICA EM CÃES
Authors: Reis Luciano Wagner Dórea , Alves Sérgio de Oliveira , Araújo João pedro de Andrade , Canedo Giovanna Reggiani , Da Silva Aline Milca
Published: May 2023

A Cannabis sativa é uma planta que apresenta vários benefícios terapêuticos para animais, como tratamento da dor neuropática, inflamatória e osteoartrose. A dor é bastante recorrente na rotina clínica, sendo importante seu manejo para que seja ofertada uma melhor qualidade e conforto de vida para o paciente. O estudo objetivou identificar, a partir de evidências científicas, as características da utilização medicinal do uso de Cannabis Sativa no tratamento da dor crônica no cão, utilizando um dos seus princípios ativos, canabidiol (CBD). Foi feito uma revisão bibliográfica onde foi realizada a busca de estudos experimentais e relatos de caso em bases de dados eletrônicos, sendo incluídas fontes contendo a utilização do CBD em animais, que abordaram controle da dor, assim como escore avaliativo da dor antes, durante e após o tratamento proposto. Após eleger e analisar 54 estudos percebe-se que na medicina veterinária o uso do canabidio é insuficiente, uma vez  que o foco da maior parte dos estudos clínicos é voltado para medicina humana. Ainda assim, a utilização de CBD mostrou-se eficaz, confirmando uma nova alternativa para o controle da dor em animais.
Digital Financial Behavior of Rural Farmer Households During the Covid-19 Pandemic

Authors: Mukhlis Imam , Pratama Andik , Wahyuningsih Diah
Published: May 2023

This study aims to analyze the behavior of the digital economy of rural farmers in using direct cash assistance from the government during the Covid-19 pandemic. Direct cash assistance is a social protection program from the government to maintain the ability to have purchasing power in meeting the needs of life. The subjects of this study were people who had livelihoods as farmers in various villages in Semen District, Gampengrejo District and Ngasem District, Donomulyo District, Sumbermanjing Wetan District, Wates District, and Binangun District, East Java Province, Indonesia. This type of research is explanatory and the data analysis method is carried out descriptively. The sampling method was carried out using a simple random sampling method on groups of farmer households in the village within the period of April-June 2021. Meanwhile, data collection is carried out by conducting in-depth interviews, observations, and distributing questionnaires. The number of samples that can be collected from data collection are 760 respondents. The results of the study provide results that the behavior of the digital economy of rural farmers is influenced by cost, privacy, and social factors. Direct cash assistance provided by the government to farmers encourages changes in farmers' behavior in conducting non-cash transactions. To encourage the digitization of non-cash transactions, it is necessary: the existence of digital literacy activities for farmers through the provision of IT supporting facilities and infrastructure, assistance in the use of IT in financial transactions, and, the existence of regulations that can facilitate farmers' access to digital financial transaction activities.
The Impact of Fluctuation of the International Oil Prices on the Public Budget of Iraq (An Analytical Study During the Period from (2001 - 2019)

Authors: Kadhim Roaa
Published: May 2023

This research aimed to Determining the extents to which oil domination over public finance in Iraq has reached and determining the proposed future scenarios ,Iraqi economy loses an amount more than a billion dollars due to lower crude oil prices, the amount of one dollar in the price of a barrel of oil produced by the compounding of the budget deficit, to be investment spending is the victim of any drop in oil prices, which means stop wheel ages and growth in Economy, It was also suggested that Mali establish a sovereign fund that is tied to the country's fiscal policy and serves as collateral for future generations, with the savings portion of oil revenues and other miscellaneous income channeled through the fiscal deficit to compensate for and act as an emergency fund. That is why the fluctuation of oil prices and its impact on the general budget was chosen, and data were collected from the Central Bank, the Iraqi Ministry of Finance and OPEC, and the study is based on a review of the various literature presented in the paper.  For the purpose of the current study, the oil sector was chosen. The variables of exchange rate, gross domestic product, price per barrel, oil revenues, oil revenues, and inflation were measured with the help of data on a scale by using the multiple regression model. Indeed, the volatility of oil prices has been measured. The study concluded that there is an impact of oil price fluctuation on the general budget . The Iraqi economy loses more than one billion dollars due to the drop in crude oil prices by one dollar in the price of a barrel of oil it exports, which exacerbates its budget deficit. This paper contributes to the search for an alternative standard model that is able to effectively explain the impact of oil price fluctuations on the public budget in Iraq.This paper will be valuable for decision makers in Iraq to know the impact of oil price fluctuations on the public budget and reduce the budget's dependence on oil revenues.
The Multifaceted Dimensions of the Wage Gap in Ecuador

Authors: Pontarollo Nicola , Segovia Joselin , Orellana Mercy
Published: May 2023

This study examines the determinants of wage gap differences based on gender, ethnicity, and area of residence (urban vs. rural) in Ecuador for the years 2007 and 2017. By combining the Oaxaca-Blinder decomposition with unconditional quantile regression, we identify the extent to which the wage gap between two groups is due to characteristics (endowment) or unexplained factors at various points of the distribution, i.e. for low-, medium- and high-income workers. Results show that, on average, the gender and ethnic wage gap in 2017 increased slightly with respect to 2007, while the area wage gaps remained stable. However, progresses have mainly benefited those at the top of the income distribution, while disparities have widened for those at the bottom. As regards endowment effects, education mainly explains area and ethnicity wage gaps, while there is an important unexplained part that contributes more to gender wage differentials.
Factors Affecting University Graduates’ Employability in Egypt Using Egyptian University Students as a Case Study

Authors: Ead Hamed , Fahmy Heba , Elbadry Abdallah
Published: May 2023

Employability refers to the process of gaining initial employment, maintaining employment, and successfully obtaining new employment if required. In simple terms, employability is about being capable of obtaining and keeping fulfilling work. Employability is having a set of skills, including knowledge, understanding, and personal attributes that make a person more likely to choose and secure occupations in which they can be satisfied and successful. Employability depends on knowledge (what you know), skills (what you do with what you know), and attitudes (how you approach things). In higher education, the employment of university graduates is influenced by many factors including institutional ranking, image, branding, and program structure. Therefore, university reputation in specific programs is important and affects the employability of graduates directly.

In a recent paper by the corresponding author, we argued that university branding is critical for developing a favorable image and impacts one’s identity formation and promotion substantially, thus differentiating and placing one in a highly competitive context. In this paper, we will investigate the factors that influence employability among university graduates and determine which ones can affect the overall graduate employability of university graduates in Egypt. These factors include academic branding, academic performance, technical skills, communication skills, personality, leadership and motivational skills, and teamwork and problem-solving skills, taken as independent variables, while overall graduate employability was considered the dependent variable. In addition, we consider the impact of the university’s reputation on graduate employability.

Survey methods were used on 500 graduates and undergraduates (fourth level) from different Egyptian universities who have not yet performed employability behavior, chosen at random, by using exploratory factor analysis to validate the items under those independent variables and structural equation modeling with AMOS to test the hypothesized relationship between the independent variables and the dependent variable. The questionnaire had 20 questions, including demographic inquiries and questions about the abovementioned topics. The findings of this study can help scholars further investigate the employability aspects and guide fresh graduates in acquiring the required employability skills while assisting companies in recruiting suitable people with the required skills and performance.
Board Attributes, Political Connections and External Auditor Pricing Behaviour in Nigeria: Statistical versus Machine Learning Analyses
Authors: Adedapo soyemi Kenny
Published: May 2023

Anchored on Simunic’s audit fees model, this study examined the influence of a few board attributes on pricing behavior of external auditors in Nigeria. Besides, political connections that are largely prevalent among corporate entities in Nigeria, is also introduced as part of explanatory variables. Data were gathered from audited annual accounts and reports of 50 quoted non-financial firms for 7 years from 2014 – 2020, culminating into 350 data/set observations. Both statistical learning (SL) and machine learning (ML) data analytic techniques were adopted to estimate model specified for the study. The results indicated that firm size and political connections are effective determinants of pricing behaviour of auditors, accounting for 80% variations therein. This is similar to results obtained from machine language analysis. However, board attributes, as well as profitability (return on total assets), in addition to firm size and political connections, displayed positive and statistical significant relationship when BIG4 was adopted as proxy for pricing behavior of auditors. The statistical and machine learning analyses accounted for 21% and 86% variations in pricing behavior of auditors respectively. This study largely conforms to extant studies and aligns with demand-based perspective linking board attributes and audit pricing behavior. Consequently, board attributes, political connections, firm size and profitability are active variables available to firms, which must be effectively managed in order to influence the amount charged by external auditors in Nigeria.
Componentes de las exportaciones de confecciones colombianos
Authors: Londoño Arias José Albán , Valencia Cárdenas Marisol
Published: May 2023

Las exportaciones latinoamericanas han tenido diversificaciones importantes y una determinada participación de productos primarios y minerales, que dejan preguntas acerca de la degradación del medio ambiente, como también, del verdadero potencial de la región. En esta investigación se realiza una descripción y análisis de series de tiempo de exportaciones de las confecciones, presentando el alcance correlacional y analítico para Colombia, de los aranceles 61 y 62, en relación con las del grupo de países de agregación de América Latina, entre 2002 y 2021, aplicando la estimación del modelo de series de tiempo lineal dinámico. Entre los resultados, se encuentra que hay una baja participación de los productos colombianos, en las exportaciones de estas confecciones y además, se observa un decrecimiento del valor comercializado en el tiempo, sin embargo, se encuentra un potencial de mejora para los meses de vacaciones, días especiales, favoreciendo dicho comercio, que, además, mejora con el aumento de la inversión extranjera directa. Entre las limitaciones detectadas, se aprecia que es menester mejorar apoyos, innovación y gestión financiera de este tipo de empresas.
The Effect of ESG Criteria on Company Valuation: A Quantitative Approach Applied to the O&G Sector

Authors: García Amate Antonio
Published: May 2023

The integration of Environmental, Social and Governance (ESG) criteria implies that they must be explicitly introduced into valuation models and investment decisions. Socially Responsible Investment (SRI) does not take into account this integration, so it is necessary to know the real impact that ESG criteria have on the valuation of actions to carry out effective investment decisions. The approach used is the Value – Drivers Adjustment (VDA) through the Discounted Cash Flow (DFC) method for Shell PLC as one of the most influential O&G companies in the energy transition. The results of the analysis reveal that the impact of ESG criteria on valuation translates into a reduction of 29.11% of its target price. The need for investment and the rising cost of capital explain these result. This results in a more comprehensive valuation method, where ESG criteria are no longer supplementary information and become indirect financial elements.
The Correlation of Motivation and Habit with Learning Outcomes in New Normal Era
Authors: Muhammad Indra  , Sudji Munadi  , Tika Widari
Published: May 2023

This article explores the relationship between learning motivation, learning habit, and the learning outcomes of grade 11th class vocational school students in the practice of lathe machining in the new normal era. This study uses a quantitative approach with research subjects in vocational schools in the field of mechanical engineering expertise. Data collection using questionnaires, tests, and documentation. Pearson Product Moment correlation analysis technique, t-test, and F test, using SPSS software. The results of this study are divided into two, namely: single regression and multiple regression will be explained as follows. 1) Single regression includes: a) learning motivation variable with learning outcomes (R) value of 0.465, value (r2) of 0.217 meaning that there is a relationship with the medium category of learning motivation with learning outcomes, (b) learning habit with learning outcomes (R) value of 0.484, the value (r2) is 0.235, meaning that there is a relationship with the medium category between learning motivation and learning outcomes. 2) Multiple regression between the variables of learning motivation and learning habit simultaneously provides a positive and significant relationship with learning outcomes. This is indicated by the value (R) of 0.550, and the value (r2) is 0.302 which means that there is a relationship with a moderate category between learning motivation and learning habit on the learning outcomes of vocational school students in the practice of lathe machining grade 11th class in the new normal era. The limitations and implications of the research will be discussed in more detail in the discussion. Keywords: Learning Motivation, Learning Habit, Learning Outcomes
Factors Influencing Online Learning Students’ Satisfaction in UIN Fatmawati Bengkulu
Authors: Eko Ngabdul Shodikin  , Agung Rokhimawan  , Ahmad Suradi  , Setia Murningsih
Published: May 2023

The use of e-learning in education can increase efficiency and motivation in learning. The success of this online learning platform is influenced by student satisfaction. Students who are satisfied then they will be comfortable with using online learning. The success of the online learning system can be seen in student satisfaction when using the LMS and online learning software. So, this study aims to analyse student satisfaction with the online learning system. The sample of this research is students of the Tarbiyah Faculty of UIN Sukarno Fatmawati Bengkulu. The sampling technique used is convenience sampling. The independent variables used were computer self-efficacy (CSE), perceived usefulness (PU), and perceived ease of use (PEU). The dependent variable in this study was student satisfaction (SAT). This data analysis technique used Structural Equation Modelling (SEM) with SmartPLS software. The results of this study indicated that the computer self-efficacy had a significant positive effect on the perceived ease of use and the perceived usefulness. The perceived ease of use and perceived usefulness significantly positively affected the student’s satisfaction.
 Keywords: Online Learning Higher Education, Students’ Satisfaction, Structural Equation Modeling
Responding to Trends in Digital-Based Classroom Learning: Efforts to Improve Learning Outcomes of Indonesian Millennial Students at Bengkulu University
Authors: Baryanto Baryanto , Sembiring Darmawanta , Bangkara B.M.A.S. Anaconda , Khasanah Khasanah , Aunurrahman Aunurrahman
Published: May 2023

Through interviews with several academic activities and campus management at the University of Bengkulu, we have managed to obtain several data which are also backed up by secondary data from the publications we reviewed to answer the study themes which aim to respond to digital-based learning trends in efforts to improve millennial student learning outcomes. The author understands that the trend of using digital in learning is familiar. However, to gain new knowledge, we try to get direct data through conversations with staff and decision-making at the University of Bengkulu. We can analyze the results of both the interview data and the review of various sources under a phenomenological approach, in which, among other things, we coded data and revised the data to interpret the data. The latest data contains elements of validity and reliability that can be relied upon. Based on the study's results and available data, the University of Bengkulu believes that digital-based learning is a practical, transformative, and productive solution to improving the learning outcomes of Indonesian students who are said to be millennials. These findings will provide new insights into future discussions of similar studies.  Keywords: Digital Base Classroom, Improving Learning Outcome, Digital Classrom Learning
Impact of Innovative Learning in Mathematics and Natural Sciences on Student Learning Achievements: A Meta-Analysis
Authors: Niza  , Slamet Suyanto
Published: May 2023

This study was to analyze the impact of innovative learning on student learning achievement in Mathematics and Natural Sciences from 2014 until 2021. The data collection method used in this study is a meta-analysis, where the researchers would search related articles through Google Cendekia (Google Scholars) and ScienceDirect. This research obtained 227 articles. All selected articles cover the research conducted in schools, from elementary to high school level. These articles will be analyzed in several steps: (1) determining research domains that will be summarized; (2) selecting the types of collected publications; (3) collecting results of studies or literature; (4) listing research data; (5) calculating the effect size of each source or study. After passing this five-step process, 21 articles that discussed how innovative learning in mathematics and natural sciences affects student achievement were selected. These articles will be analyzed using the JAMOVI application. The results found an average difference, ranging from -0.99 to 3.10.
Keywords:  Innovative Learning, Natural Sciences, Learning Achievements
Faktor-faktor yang Mempengaruhi Keputusan Orang Tua Untuk Memberikan Vaksinasi Covid-19 pada Anak
Authors: Nurrizka Rahmah Hida , Irvan Moh. , Hardianto Vernanda Eka
Published: May 2023

Kebijakan vaksinasi covid-19 pada anak menimbulkan respon yang berbeda pada masyarakat khususnya orang tua. Masih terdapat orang tua yang memutuskan untuk tidak memberikan vaksinasi Covid-19 pada anak mereka. Penelitian ini bertujuan untuk melihat faktor-faktor yang mempengaruhi keputusan orang tua untuk memberikan vaksinasi covid-19 pada anak.  Beberapa variabel independent yang dilihat dalam penelitian ini yaitu karakteristik anak, karakteristik orang tua, riwayat penderita Covid-19 di keluarga dan riwayat vaksinasi Covid-19 pada anak kerabat. Penelitian ini merupakan penelitian survei cross-sectional dengan jumlah sampel sebanyak 280 orang tua yang memiliki anak usia 6-11 tahun di Jabodetabek. Hasil penelitian menunjukkan bahwa masih banyak responden yang mengatakan takut terhadap efek samping dari vaksinasi covid-19 pada anak (39,4%), belum mengetahui arahan tempat vaksin dan belum tahu vaksinasi covid-19 bisa diberikan pada anak (15,2%) serta masih ragu terhadap vaksinasi covid-19 pada anak (6,1%). Variabel dominan yang mempengaruhi keputusan orang tua dalam memberikan vaksinasi pada anak yaitu usia anak (p-value: 0,001, odds ratio: 1,677, confidence interval: 1,252-2,246), jumlah anak (p-value: 0,013 odds ratio: 0,304, confidence interval: 0,070-1,445) dan riwayat vaksinasi covid-19 pada anak kerabat (p-value: 0,000, odds ratio: 4,881, confidence interval: 2,175-10,954). Penelitian ini menyimpulkan terdapat keraguan dan hambatan orang tua dalam membuat keputusan untuk memberikan vaksinasi covid-19 pada anak.  Untuk dapat merespon dengan baik kebijakan vaksinasi covid-19 pada anak orang tua membutuhkan informasi dan contoh yang baik terhadap kebijakan vaksinasi covid-19 pada anak.
Mengapa Masyarakat Kecamatan Entikong Kabupaten Sanggau Berobat ke Sarawak, Malaysia
Authors: Widiyastuty Feny , Suryawati Chriswardani , Arso Septo Pawelas
Published: May 2023

Tingginya minat masyarakat Indonesia berobat keluar negeri semakin meningkat dari tahun ke tahun membuat pemerintah kehilangan potensi sumber pendapatan negara yang berasal dari sektor pelayanan kesehatan. Kedekatan geografis menyebabkan masyarakat di daerah perbatasan memiliki peluang besar dalam memanfaatkan fasilitas pelayanan kesehatan di negara tetangga, salah satunya adalah masyarakat di Kecamatan Entikong yang berbatasan langsung dengan Sarawak, Malaysia. Penelitian ini bertujuan untuk menganalisis faktor yang berhubungan dengan pemanfaatan pelayanan kesehatan di Sarawak oleh masyarakat Kecamatan Entikong. Penelitian ini merupakan penelitian kuantitatif observasional dengan menggunakan desain studi cross sectional. Populasi penelitian adalah masyarakat di Kecamatan Entikong berusia 20 – 50 tahun berjumlah 9.337 orang. Sampel penelitian berjumlah 100 responden menggunakan tekhnik proporsional random sampling. Penelitian dilakukan pada bulan September hingga Oktober 2022. Analisis data menggunakan uji chi-square dan regresi logistik. Hasil penelitian diperoleh variabel yang berhubungan dengan pemanfaatan pelayanan kesehatan adalah pendapatan (p=0,012), kelompok referensi (p=0,026) dan persepsi pelayanan kesehatan (p=0,009) sedangkan variabel pendidikan (p=0,961) dan pekerjaan (p=0,589) tidak berhubungan dengan pemanfaatan pelayanan kesehatan negara Malaysia. Terdapat hubungan pendapatan, kelompok referensi dan persepsi pelayanan kesehatan dengan pemanfaatan pelayanan kesehatan. Tidak terdapat hubungan pendidikan dan pekerjaan dengan pemanfaatan pelayanan. Masyarakat dengan pendapatan tinggi lebih berpotensi memanfaatkan pelayanan kesehatan di Sarawak.  Diharapkan agar Puskesmas Entikong, Dinas Kesehatan Kabupaten Sanggau dan Pemerintah Daerah Kabupaten Sanggau dapat menyediakan fasilitas pelayanan kesehatan primer dan fasilitas pelayanan kesehatan rujukan yang bermutu dan berkualitas di daerah perbatasan untuk meningkatkan daya saing terhadap fasilitas pelayanan kesehatan di Sarawak.
ON THE ISSUE OF QUALITY ASSURANCE IN THE PROCUREMENT OF GOODS, WORKS, SERVICES FOR STATE AND MUNICIPAL NEEDS
Authors: Родионова С.Н. , Макарова Н.В.
Published: May 2023

Проблема обеспечения качества при закупке товаров, работ, услуг для государственных (муниципальных) нужд относится к одной из важнейших при размещении заказов. Поскольку законом требования к качеству закупаемых товаров не регламентируется, поэтому заказчики при разработке технического задания могут опираться на положения стандартов, или использовать в своей работе рекомендации Правительства РФ, прописанных в общих правилах определения требований к закупаемым заказчиками отдельным видам товаров, работ, услуг.

The problem of quality assurance in the procurement of goods, works, services for state (municipal) needs is one of the most important when placing orders. Since the law does not regulate the requirements for the quality of purchased goods, therefore, customers can rely on the provisions of standards when developing technical specifications, or use in their work the recommendations of the Government of the Russian Federation prescribed in the general rules for determining requirements for certain types of goods, works, and services purchased by customers.
Nitrilium Ion Trapping as a Strategy to Access Structurally Diverse Heterobiaryl-containing Peptide Macrocycles
Authors: Yudin Andrei , Diamandas Matthew , Heller Nicholas
Published: May 2023

Biaryl and heterobiaryl-containing cyclic peptides represent promising scaffolds in the development of bioactive molecules. The incorporation of heterobiaryl motifs continues to pose synthetic challenges, which is partially due to the difficulties in effecting late-stage metal-catalyzed cross-couplings. We report a new strategy to form heterobiaryls that is based on trapping nitrilium ions. The sequence is exemplified using oxadiazole- and oxazole-containing biaryl linkages. NMR analysis and molecular dynamics simulations reveal structural control elements common to each member of the heterobiaryl containing peptide family in this study. Strategic substitutions on the C-terminal aminobenzoic acid moiety paired with installation of oxadiazole or oxazole heterobiaryl backbone linkages allow for the modulation of peptide backbone conformation, which should assist efforts to optimize the biophysical properties of peptide macrocycles.
Femtosecond Laser-Ablative Aqueous Synthesis of Multi-Drug Antiviral Nanoparticles
Authors: Schmitt Rebecca , Davidson Bruce , He Dihua , Bulmahn Julia , Sambhara Suryaprakash , Knight Paul , Prasad Paras
Published: May 2023

Nanomedicine offers a number of innovative strategies to address major public health burdens, including influenza and SARS-CoV-2. In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation which can be used for the treatment of influenza, SARS-CoV-2, and their co-infections. The influenza antiviral, baloxavir marboxil; the SARS-CoV-2 antiviral, remdesivir; and the anti-inflammatory drug, dexamethasone, were co-ablated in aqueous media, followed by surface modification with a cationic polymer to generate a nanoparticle with a diameter of ~73 nm and a positive zeta potential. We demonstrate high efficacy of these nanoparticles against Influenza Virus A using a clinically relevant, in vitro primary mouse trachea epithelial cell-air-liquid interface culture model. These findings demonstrate great promise both for the use of femtosecond laser ablation to generate multi-drug nanoparticles, as well as for the potential anti-viral effects of our nanoformulation against other respiratory virus infections such as SARS-CoV-2.
A Non-Rate-Determining Redox Process Dictates the Oxygen Evolution Tafel Slope of MnO2
Authors: Yatsuzuka Koichi , Adachi Kiyohiro , Hashizume Daisuke , Nakamura Ryuhei , Ooka Hideshi
Published: May 2023

Electrocatalytic activity is markedly influenced by the Tafel slope, which dictates the sensitivity of the catalytic current with respect to the potential. Differences in the Tafel slope between electrocatalysts have been rationalized based on redox pre-equilibria preceding the rate-determining step. However, no study has experimentally observed a non-rate-determining redox event that directly correlates with the Tafel slope. Here, we show that the Tafel slope of the oxygen evolution reaction (OER) on alpha-MnO2 is markedly influenced by a Mn(III)/Mn(II) redox process located 500 mV more negative than the OER onset potential. Upon repeated cyclic voltammetry sweeps, a correlation was observed between the Tafel slope and the peak position of a redox event, which was assigned to a Mn(III)/Mn(II) redox couple based on the potential dependence of the UV-vis spectra. Notably, the UV-vis absorption of Mn(III) did not diminish even after the OER was initiated, and another redox process was observed at the OER onset, indicating that Mn(III)/Mn(II) is not the rate-determining step for OER on alpha-MnO2 in alkaline pH. Numerical simulations using physicochemical parameters of Mn(III)/Mn(II) obtained from trumpet plot analyses reproduce the experimental Tafel plots, indicating that even non-rate-determining steps should be considered during catalyst design.
Identification of a novel enhancer essential forSatb1expression in TH2 cells and activated ILC2s
Authors: Nomura Aneela , Kobayashi Tetsuro , Seo Wooseok , Ohno-Oishi Michiko , Kakugawa Kiyokazu , Muroi Sawako , Yoshida Hideyuki , Endo Takaho A , Moro Kazuyo , Taniuchi Ichiro
Published: May 2023

The genome organizer, special AT-rich binding protein-1 (SATB1), functions to globally regulate gene networks during primary T cell development and plays a pivotal role in lineage specification in CD4+helper-, CD8+cytotoxic-, and FOXP3+regulatory-T cell subsets. However, it remains unclear howSatb1gene expression is controlled, particularly in effector T cell function. Here, by using a novel reporter mouse strain expressing SATB1-Venus and genome editing, we have identified acis-regulatory enhancer, essential for maintainingSatb1expression specifically in TH2 cells. This enhancer is occupied by STAT6 and interacts withSatb1promoters through chromatin looping in TH2 cells. Reduction ofSatb1expression, by the lack of this enhancer, resulted in elevated IL-5 expression in TH2 cells. In addition, we found thatSatb1is induced in activated group 2 innate lymphoid cells (ILC2s) through this enhancer. Collectively, these results provide novel insights into howSatb1expression is regulated in TH2 cells and ILC2s during type 2 immune responses.
The Effect of Higher Financing Costs on Job Openings and Online Job Postings
Authors: Bailey Adiah L. , Hernandez Martinez Victor
Published: May 2023

In this Economic Commentary, we consider whether the declines in vacancies seen in the second half of 2022 could have been driven by monetary policy tightening. We look at whether the variation in this decline across industries and states was consistent with increases in the federal funds rate. Our first strategy focuses on variation at the industry level in exposure to higher borrowing costs. Our second leverages geographic differences in the effect of monetary policy tightening on financing costs. Both strategies suggest that monetary policy is, at least in part, responsible for the recent decline in vacancies.
b-Chromatic number of some wheel related graphs
Authors: S. K. Vaidya  , M. S. Shukla
Published: May 2023

A proper coloring $f$ is a $b$-coloring of the vertices of graph $G$ such that in each color class there exists a vertex that has neighbours in every other color classes. The $b$-chromatic number $\varphi(G)$ of a graph $G$ is the largest integer $k$ for which $G$ admits a $b$-coloring with $k$ colors. If $\chi(G)$ is the chromatic number of $G$ and $b$-coloring exists for every integer $k$ satisfying the inequality $\chi(G) \leq k \leq \varphi(G)$ then $G$ is called $b$-continuous. The $b$-spectrum $S_b(G)$ of a graph $G$ is the set of $k$ integers(colors) for which $G$ has a $b$-coloring. We investigate $b$-chromatic number for the graphs obtained from wheel $W_n$ by means of duplication of vertices. We also discuss $b$-continuity and $b$-spectrum for such graphs.
Existence of mild solution result for fractional neutral stochastic integro-differential equations with nonlocal conditions and infinite delay
Authors: N. Ait ouali  , A. Kandouci
Published: May 2023

We investigate in this paper the existence of mild solutions for the fractional differential equations of neutral type with nonlocal conditions and infinite delay in Hilbert spaces by employing fractional calculus and Krasnoselski-Schaefer fixed point theorem. Finally an example is provided to illustrate the application of the obtained results.
Some Results for a Four-Point Boundary Value Problems for a Coupled System Involving Caputo Derivatives
Authors: M. Houas  , M. Benbachir  , Z. Dahmani
Published: May 2023

Motivated by the problem (1.1) in [5], in this paper, we prove the existence and uniqueness of solutions for the following system of fractional differential equations with four point boundary conditions:$$\left\{\begin{array}{l}D^\alpha x(t)+f\left(t, y(t), D^\delta y(t)\right)=0, t \in J \\D^\beta y(t)+g\left(t, x(t), D^\sigma x(t)\right)=0, t \in J \\x(0)=y(0)=0, x(1)-\lambda_1 x(\eta)=0, y(1)-\lambda_1 y(\eta)=0 \\x^{\prime \prime}(0)=y^{\prime \prime}(0)=0, x^{\prime \prime}(1)-\lambda_2 x^{\prime \prime}(\xi)=0, y^{\prime \prime}(1)-\lambda_2 y^{\prime \prime}(\xi)=0\end{array}\right.$$where $3<\alpha, \beta \leq 4, \alpha-2<\sigma \leq \alpha-1, \beta-2<\delta \leq \beta-1,0<\xi, \eta<1$, and $D^\alpha, D^\beta$, $D^\delta$ and $D^\sigma$, are the Caputo fractional derivatives, $J=[0,1], \lambda_1, \lambda_2$ are real constants with $\lambda_1 \eta \neq 1, \lambda_2 \xi \neq 1$ and $f, g$ continuous functions on $[0,1] \times \mathbb{R}^2$.
Some curvature properties of (κ, µ) contact space forms
Authors: Ali Akbar  , Avijit Sarkar
Published: May 2023

The object of the present paper is to find Ricci tensor of $(k, \mu)$ space forms. In particular we prove that a three dimensional $(k, \mu)$ space forms is $\eta$-Einstein for $\mu=\frac{1}{2}$. We also study three dimensional $(k, \mu)$ space forms with $\eta$ - parallel and cyclic parallel Ricci tensor for $\mu=\frac{1}{2}$. We also prove that every $(k, \mu)$ space forms is locally $\phi-$ symmetric.
Nonlinear D-set contraction mappings in partially ordered normed linear spaces and applications to functional hybrid integral equations
Authors: Bapurao C. Dhage
Published: May 2023

In this paper the author introduces the notion of partially nonlinear D-set-contraction mappings in a partially ordered normed linear space and prove some hybrid fixed point theorems under certain mixed conditions from algebra, analysis and topology. The applications of abstract results presented here are given to perturbed nonlinear hybrid functional integral equations for proving the existence as well as global attractivity of the comparable solutions under certain monotonic conditions. The abstract theory developed in this paper is also useful to develop the algorithms for the solutions of some nonlinear problems of analysis and allied areas of mathematics.
Mixed domination in an M-strong fuzzy graph
Authors: A. Mohamed Ismayil  , S. Ismail Mohideen
Published: May 2023

In this paper, mixed dominating set, mixed domination number, mixed strong domination number and mixed weak domination number of an M-strong fuzzy graph $G=(\sigma, \mu)$ are defined. Also these numbers are determined for various standard fuzzy graphs. The relationship between these numbers and other well known numbers are derived.
Some vector-valued statistical convergent sequence spaces
Authors: Kuldip Raj  , Suruchi Pandoh
Published: May 2023

In the present paper we introduce some vector-valued statistical convergent sequence spaces defined by a sequence of modulus functions associated with multiplier sequences and we also make an effort to study some topological properties and inclusion relation between these spaces.
A note on Civin-Yood Theorem for locally C*-algebras
Authors: Alexander A. Katz
Published: May 2023

In the present note we establish Civin-Yood Theorem for locally $C^*$-algebras, i.e. we show that if $A$ be a locally $C^*$-algebra, and $J$ be its closed Jordan ideal, then $J$ is as well a closed two-sided ${ }^*$-ideals in $A$.
Numerical solution of weakly singular integro-differential equations
Authors: Mostefa NADIR
Published: May 2023

In this work, we prove the existence and uniqueness of the solution of weakly singular integro-differential equations. After some transformations direct numerical schemes using collocation methods are proposed for any peicewise closed contours.
Oscillation criteria of third order nonlinear neutral difference equations
Authors: G.Ayyappan
Published: May 2023

In this paper we consider the third order nonlinear neutral difference equation of the form$$\Delta\left(r_n\left(\Delta^2\left(x_n \pm p_n x_{\sigma(n)}\right)\right)^\alpha\right)+f\left(n, x_{\tau(n)}\right)=0,$$we establish some sufficient conditions which ensure that every solution of this equation are either oscillatory or converges to zero. Examples are provided to illustrate the main results.
Simulation Research on the Effect of Spreading Process Parameters on the Quality of Lunar Regolith Powder Bed in Additive Manufacturing
Authors: Tian Qi , Luo Bing
Published: May 2023

Lunar surface additive manufacturing with lunar regolith is a key step in in-situ resource utilization. The powder spreading process is the key process, which has a major impact on the quality of the powder bed and the precision of molded parts. In this study, the discrete element method (DEM) was adopted to simulate the powder spreading process with a roller. The three powder bed quality indicators, including the molding layer offset, voidage fraction, and surface roughness, were established. Besides, the influence of the three process parameters, which are roller’s translational speed, rotational speed, and powder spreading layer thickness on the powder bed quality indicators was also analyzed. The results show that with the reduction of the powder spreading layer thickness and the increase of the rotational speed, the offset increased significantly; when the translational speed increased, the offset first increased and then decreased, which resulted in an extreme value; with the increase of the layer thickness and the decrease of the translational speed, the values for voidage fraction and surface roughness significantly reduced. The powder bed quality indicators were adopted as the optimization objective, and the multi-objective parameter optimization was carried out. The predicted optimal powder spreading parameters and powder bed quality indicators were then obtained. Moreover, the optimal values were then verified. This study can provide informative guidance for in-situ manufacturing at the moon in future deep space exploration missions.
Pengaruh Orientasi Kewirausahaan, Orientasi Pasar, dan Manajemen Kualitas Total Terhadap Kinerja UMKM di Kabupaten Karanganyar
Authors: Aji Lindungi Semesta , Harini Harini , Hindrayani Aniek
Published: May 2023

This study aims to determine the effect of entrepreneurial orientation, market orientation, and total quality management on the performance of SMEs. The research method used is descriptive quantitative with purposive sampling technique and a sample of 187 respondents. The data collection technique uses a questionnaire that has been tested for validity and reliability. This study uses data analysis techniques using multiple linear regression analysis. The results of this study indicate that there is a positive and significant influence between entrepreneurial orientation on MSME performance, market orientation has a positive and significant effect on MSME performance, total quality management has a positive and significant effect on MSME performance, as well as entrepreneurial orientation, market orientation, and total quality management as a whole. simultaneously has a positive and significant effect on the performance of SMEs.
Pengembangan Media Pembelajaran Ekonomi Berbasis Android Dengan Platform Kodular Pada Materi Pengantar Ilmu Ekonomi Untuk Siswa Kelas X di SMAN Balung Kabupaten Jember Tahun Ajaran 2022/2023
Authors: Satriani Nimas , Ani Hety Mustika , Mardiyana Lisana Oktavisanti
Published: May 2023

This research was carried out with the aim of developing an android- based economic learning media with the KODULAR platform in an interesting and effective Introduction to Economics material for class X students at SMAN Balung, Jember Regency. This type of research is development research with the ADDIE model which is limited to the implementation stage. This study used four research instruments, namely validation sheets, questionnaires, interviews, and documents. Data analysis techniques applied include testing the level of attractiveness and level of effectiveness. The results of this study indicate that the developed economic learning media is attractive with a limited group trial percentage of 89.85% and a large group trial percentage of 93.78% with very attractive criteria. The developed media is also effective because it can achieve learning objectives, showing an increase in student scores in the limited group trial from 80.80 to 89.20 and in the broad group trial from 80.22 to 90.11. Thus, these learning media are categorized as interesting and effective learning media.
Pengaruh Lingkungan Keluarga dan Pendidikan Kewirausahaan Terhadap Minat Berwirausaha Mahasiswa FKIP UNS Dimoderasi Peran Program Studi
Authors: Hudaya Arinie , Noviani Leny , Sangka Khresna Bayu
Published: May 2023

This study aims to determine the influence of the family environment and entrepreneurship education partially affect the interest in entrepreneurship and the role of the study program in strengthening the influence on the entrepreneurial interest of FKIP UNS students. This research is a quantitative method research. The population in this study is active students of FKIP UNS batch 2018-2020. The sampling technique in this study was proportionate random sampling with a sample of 400 respondents. Through the Moderated Regression Analysis (MRA) hypothesis test, the results showed (1) family environment (2) entrepreneurship education has a positive and significant influence on entrepreneurial interest. Then, (3) the role of the study program was found not to be a moderator variable so that it did not have a moderating effect so that this variable could not strengthen the influence of the family environment on entrepreneurial interest. In addition, (4) the role of the study program was found to have the nature of weakening the influence of entrepreneurship education on entrepreneurial interest.
Faktor-Faktor Yang Memengaruhi Penerapan Metode Pembayaran Digital Pada Usaha Mikro, Kecil, dan Menengah (UMKM) di Surakarta Dalam Menghadapi Era Revolusi Industri 4.0
Authors: Putri Iga Destya , Hindrayani Aniek , Totalia Salman Alfarisy
Published: May 2023

This study aims to analyze the determinants of the attitudes and intentions of UMKM in Surakarta City in implementing the digital payment system. This research is a quantitative descriptive research with 384 respondents as subjects of UMKM in Surakarta City who have implemented a digital payment system. The sampling technique was carried out using purposive sampling, namely MSMEs that have implemented digital payments. Data analysis technique using SEM-PLS. The results of the study show that perceived convenience influences perceptions of usefulness and attitudes of UMKM in Surakarta City in implementing payments. Next, the perception of expediency influences the attitudes and intentions of UMKM in Surakarta City in implementing digital payments. In addition, trust influences the attitudes and intentions of UMKM in Surakarta City in implementing digital payments. Finally, attitudes influence the intention of UMKM in Surakarta City to implement digital payments.
La justicia alternativa como mecanismo para disminuir la carga procesal en el sistema judicial ecuatoriano
Authors: Zurita Acurio Carlos
Published: May 2023

El presente trabajo analiza la justicia alternativa como mecanismo para disminuir la carga procesal en el sistema judicial ecuatoriano. La justificación del tema radica en la necesidad de encontrar alternativas a la sobrecarga de trabajo que enfrenta el sistema judicial, lo que se traduce en una falta de eficacia en su resolución. Además, la implementación de la justicia alternativa se encuentra en línea con los principios de acceso a la justicia pronta y efectiva. El objetivo general es analizar la efectividad de la justicia alternativa en la disminución de la carga procesal en el sistema judicial ecuatoriano. Para ello, se plantean estos objetivos específicos: Sistematizar la carga procesal en el sistema judicial e identificar las causas de la sobrecarga, analizar la percepción de los usuarios y profesionales del sistema judicial sobre la implementación de la justicia alternativa, y proponer recomendaciones para mejorar su aplicación. La metodología será de tipo descriptivo-explicativo, con un enfoque mixto. La muestra estará compuesta por usuarios y profesionales del sistema judicial. Se empleará una guía de entrevista y un cuestionario para la recolección de datos, que serán analizados mediante técnicas estadísticas y análisis de contenido. Los principales resultados de este estudio muestran que la justicia alternativa puede ser una alternativa eficaz para disminuir la carga procesal en el sistema judicial, especialmente en casos de baja complejidad. En conclusión, la implementación de la justicia alternativa en el sistema judicial puede ser la solución para disminuir la carga procesal y mejorar la eficacia en la resolución de casos.
INTER-STATE DISPARITIES IN HEALTHCARE COSTS, HEALTH INSURANCE COVERAGE AND FINANCIAL PROTECTION IN INDIA: A COMPARATIVE ANALYSIS OF NATIONAL SAMPLE SURVEYS FOR 1986-87, 1995-96, 2004 AND 2014
Authors: Gumber Anil , N. Lalitha , Dhak Biplab
Published: May 2023

By analysing data from the National Sample Survey for four rounds (1986–87, 1995–96, 2004 and 2014) this research focuses on changes in people's health seeking behaviour, the cost of treatment, and principal factors affecting health insurance premium payments by BPL and APL families. With variations between states, it is discovered that over time, less people sought care from public providers and more people preferred private providers. Despite the fact that both men and women are now more likely to seek treatment for their illnesses, a sizeable portion of the population (more in rural than in urban areas), still refuses treatment because they believe their illness is not serious enough to warrant it. Whilst the cost of healthcare has gone up over time, the difference between public and private costs of treatment has shrunk, possibly as a result of the higher recurring cost in public health facilities and imposing of user fees and cutting on the delivery of free medication. Since the middle of the 2000s, public insurance companies have offered low-cost hospitalisation insurance programmes like the Jan Arogya Bima Policy and Rashtriya Swasthya Bima Yojana (RSYB) to help with the healthcare needs of the underprivileged sector of society. According to the insurance premiums, more households that paid premiums in 2004 and 2014 belonged to groups with higher Monthly Per Capita Expenditures (MPCE) and were not economically in the poorest tier. The inter-quintile MPCE differential (between the top and bottom quintile) also reveals significant inter-state disparities in terms of the percentage of households that paid a premium and the percentage of households that had health insurance. The factors that determine whether a family enrols in health insurance imply that increasing enrolment from the poor households got coverage through RSBY. At the national level, BPL/APL households with insurance reported, on average, higher hospitalisation costs than non-insured households, with the difference being significantly higher for urban households. This finding suggests the prevalence of insurance collusion and moral hazard, particularly in the cities from developed states of Punjab, Haryana, Gujarat, and Maharashtra. Further, BPL households, particularly from rural India, have received very little financial relief as a result of the insurance.