bluuebunny/crossref_metadata_2025 huggingface dataset:
BAHAN AJAR BAHASA ARAB MENGGUNAKAN SMARTPHONE PADA SEKOLAH MENENGAH PERTAMA
Authors: Muhammad Fahrurrozi  , Safarwadi Safarwadi
Published: December 2023

Arabic is a foreign language that is inseparable from the lives of Indonesian society, which is predominantly Muslim.For Muslims, it is recommended to understand Arabic as a basis for understanding and making it easier to understand the Koran. Currently Arabic has been implemented in several places.Madrasah at the Senior High School level, students are prepared to achieve basic language competency, which includes four language skills that are taught integrally, namely listening, speaking, reading, and writing. Learning Arabic can be said to be successful if students have mastered four language skills both verbally and in writing. Because the results of this research aim to help and make it easier for students to learn Arabic with the help of applications in the form of Arabic teaching materials. This application testing is reviewed based on several criteria, namely the appearance of the application, the content of the application material, and the benefits of the application to users. The user satisfaction level of the application is 76% for teachers and 75% for students.
MEDIA PEMBELAJARAN BAHASA MELALUI MEMBACA UJARAN BAGI PENYANDANG TUNARUNGU BERBASIS ANDROID
Authors: Azmi Muhammad , M. Hafizulloh
Published: December 2023

The communication system for the deaf is non-verbal (non-verbal) communication using signs, either hand movements or body signals and facial expressions. Deafness can be defined as a condition of hearing loss. Deaf children are children who experience hearing deficiencies and therefore require special services. Deaf children have difficulty observing sounds through their hearing, therefore they have to perceive sounds or sounds or someone's expressions through their sight. In this research the author examines and analyzes the problem of Android-based language learning media through speech reading for deaf people. The purpose of writing is as a tool or alternative medium to be able to learn how to read your opponent's lip movements in the communication process. This application uses the research and development (R&D) method and in designing this learning media application, it uses the ADDIE Model (Analysis, Design, Development, Implementation, and Evaluation). The result of this research is an Android-based language learning media application through speech reading for deaf people that has been created to help the learning process, especially between teachers and deaf students in learning at SLB Muhamadiyah Kelayu.
Structure of 3-Prime Near Rings with Generalized (σ,τ)-n-Derivations
Authors:   Department of Mathematics, Aligarh Muslim University, India, ALI ASMA , BOUA ABDELKARIM ,   Department of Mathematics, Physics and Computer Science, Polydisciplinary Faculty, LSI, Taza, Sidi Mohammed Ben Abdellah University, Morocco, HUQUE INZAMAM UL ,   Department of Mathematics, Aligarh Muslim University, India
Published: December 2023

In this paper, we deﬁne generalized (σ,τ)-n-derivation for any mappings σ and τ of a near ring N and also investigate the structure of a 3-prime near ring satisfying certain identities with generalized (σ,τ)-n-derivation. Moreover, we characterize the aforementioned mappings.
1996-2018 DÖNEMİNDE GÜRCİSTAN`DA FİNANSAL GELİŞMENİN EKONOMİK BÜYÜME ÜZERİNE ETKİSİNİN SINIR TESTİ YAKLAŞIMIYLA ANALİZİ
Authors: MURSHUDOVA Rakhshada , ALAKBAROV Naib
Published: December 2023

Amaç: İktisat literatüründe finansal gelişmenin ekonomik büyüme üzerine etkisine yönelik çok sayıda çalışma vardır. Söz konusu çalışmalar konuyu farklı yönleriyle analiz ederek farklı sonuçlar ortaya koymaktadır. Bu çalışmanın amacı Gürcistan ekonomisine ilişkin yıllık veriler kullanılarak 1996-2018 dönemi için finansal gelişmenin ekonomik büyüme üzerine etkisini analiz etmektedir.

Yöntem: Bu çalışma Pesaran vd.’nin (2001) geliştirdiği ARDL eşbütünleşme sınır testi yaklaşımını kullanarak değişkenler arasındaki ilişkiyi analiz etmiştir.

Bulgular: Tahmin edilen uzun dönem analiz sonuçları Gürcistan’da finansal alandaki gelişmenin ekonomik büyümeyi olumlu şekilde etkileyeceği sonucunu ortaya koymaktadır. Bu sonuç, Gürcistan ekonomisi için finansal sektörün geliştirilmesine yönelik uygulamaların ekonomik büyüme üzerinde pozitif etki yapacağını göstermektedir.

Özgünlük: Gürcistan’da finansal gelişmelerin ekonomik büyüme üzerindeki etkisini araştırmaya yönelik az sayıda çalışma bulunması sebebiyle bu çalışmanın özgün olduğu düşünülmektedir.
Aula invertida y trabajo colaborativo en educación superior
Authors: Amar Rachida Mohamed , Amar Horía Mohamed
Published: December 2023

En el panorama educativo de los últimos años, la integración de las Tecnologías de la Información y Comunicación (TIC) en la enseñanza superior ha desempeñado un papel crucial, catalizando cambios sustanciales en la metodología y el paradigma pedagógico. Este proceso de integración no es meramente una adaptación a nuevas herramientas, sino una reconfiguración fundamental de los procesos educativos para alinearlos con las demandas y dinámicas de la sociedad contemporánea. Desde una perspectiva pedagógica, el uso de las TIC ha fomentado un enfoque más constructivista del aprendizaje, en el cual el intercambio de información y la interacción colaborativa se convierten en ejes centrales. Este cambio paradigmático implica una transición de un modelo educativo basado en la transmisión unilateral de conocimientos hacia uno que promueve la construcción colectiva y la participación activa de los estudiantes en su proceso de aprendizaje. La adopción de un modelo de educación híbrida, que combina elementos presenciales con componentes en línea, ha demostrado ser particularmente eficaz en este contexto. Este modelo no solo incrementa la flexibilidad y accesibilidad del contenido educativo, sino que también permite una personalización más profunda del aprendizaje, donde los estudiantes pueden ejercer mayor autonomía y autodirección en la selección de sus trayectorias educativas. Para los educadores, la adopción de estas nuevas metodologías implica un desafío considerable. No solo deben familiarizarse con las herramientas tecnológicas, sino también con enfoques pedagógicos innovadores, como el aula invertida, que invierte el modelo tradicional de enseñanza y aprendizaje. En este enfoque, los contenidos digitales como videos, artículos y recursos interactivos se utilizan fuera del aula para preparar a los estudiantes para actividades colaborativas y de discusión en el aula, fomentando así un aprendizaje más profundo y significativo. La integración de las TIC en la enseñanza superior es un imperativo que va más allá de la simple adopción de nuevas herramientas. Representa una evolución necesaria hacia métodos de enseñanza más dinámicos, interactivos y centrados en el estudiante, que son esenciales para preparar a los profesionales para una sociedad cada vez más dominada por la tecnología y el conocimiento. El objetivo principal de esta reflexión es analizar y destacar la necesidad de transformar los métodos de enseñanza tradicionales en la enseñanza superior, aprovechando las Tecnologías de la Información y Comunicación (TIC). Esta transformación busca no solo adaptarse a las demandas de la sociedad actual, dominada por la tecnología y el conocimiento, sino también contribuir a la formación integral de los profesionales que esta sociedad requiere.
Innovation in Adaptive Leadership Management Model through the Development of Digital Mindset in Activator School Programs
Authors:   State University of Jakarta, Indonesia, Sari Eliana , Anindhita Wiratri ,   State University of Jakarta, Indonesia, Mulyadi Muhammad ,   National Research and Innovation Institution, Indonesia, Purwoko Dwi ,   National Research and Innovation Institution, Indonesia, Madhakomala Madhakomala ,   State University of Jakarta, Indonesia, Yatimah Durotul ,   State University of Jakarta, Indonesia
Published: December 2023

This research aims to design measurement instruments of digital mindset and adaptive leadershiphip, and also design of adaptive leadershiphip management model through the development of digital mindset in activator school program. The samples are 296 teachers of activator high school taken using proportional random sampling. Measurement of adaptive leadershiphip is carried out through the distribution of questionnaire instruments prepared based on 5 (five) dimensions of adaptive leadershiphip, including: 1) Emotional intelligence, 2) Organizational justice, 3) Development, 4) Character, and 5) Problem solving. Meanwhile, digital mindset measurement is carried out through the distribution of questionnaire instruments prepared based on 7 (seven) dimensions of digital mindset, namely: 1) Abundance mindset, 2) Growth mindset, 3) Agile approach, 4) Comfort with ambiguity,5) Explorer’s mind, 6) Collaborative approach, and 7) Embracing diversity. The results of the design of the digital mindset and adaptive leadershiphip measurement instrument for activator high school teachers in DKI Jakarta have proven to be valid and reliable, so that this instrument can be used to measure the digital mindset of all activator high school teachers in the DKI Jakarta. The results of the design of the adaptive leadershiphip management model through the development of the digital mindset of activator high school teachers in DKI Jakarta can be seen in detail in Figure 12, namely the structural model of the influence of digital mindset towards adaptive leadershiphip, where of the 7 (seven) digital mindset dimensions, only 4 (four) dimensions that show a significant influence on adaptive leadershiphip, namely dimensions: abundance mindset, growth mindset, explorer mindset, and embracing diversity.
Instagram as a Publication and Archiving Media for the General Election Supervisory Agency
Authors:   Faculty of Social and Political Sciences, Universitas Tanjungpura, Pontianak, Indonesia, Zhan Fuzy Firda , Khairina Etika ,   Faculty of Social and Humanities, Universitas Putera Batam, Batam, Indonesia, Wahyudin Eri ,   Master of Management Postgraduate Program, Universitas Bina Bangsa, Banten, Indonesia
Published: December 2023

An organized documentation process with good archival management is very important for any institution, including the General Election Supervisory Body. In the current era of Industrial Revolution 4.0, archiving media is not only through physical filing but also through digital media, one of which is through the use of Instagram. This research aims to analyze the model for utilizing Instagram accounts as archiving media for the General Election Supervisory Agency using the analysis knife theory, namely politics and archiving. The method in this research is a descriptive method with a qualitative approach. Furthermore, the data that has been collected through the literature study is then interpreted so that a deeper and broader meaning and meaning can be obtained regarding the results of the research carried out. Based on the research results, it is known that the model for utilizing Instagram accounts as archiving media for the General Election Supervisory Agency is implemented based on a good governance perspective with its relevance in the development of the Industrial Revolution 4.0 towards achieving a Smart City. This utilization is carried out with government innovation in archiving to support Smart City via social media Instagram in a tri-s synergistic manner, namely from government actors, non-government actors, and community actors.
Increasing Community Knowledge in the Development of the Kampung Bandar Tourism Village of Pekanbaru City
Authors:   Lecturer in Postgraduate Program, University of Riau, Pekanbaru, Indonesia, Zulkarnain Zulkarnain , Rasyid Anuar ,   Lecturer in Postgraduate Program, University of Riau, Pekanbaru, Indonesia, Sofyani Tince ,   Lecturer in Postgraduate Program, University of Riau, Pekanbaru, Indonesia
Published: December 2023

This community service by extension was conducted in Kampung Bandar Tourism Village of Pekanbaru City at 17 June 2023. The purpose of community service activities in Kampung Bandar Pekanbaru City is to increase community knowledge about tourism village development in an effort to create community welfare. This activity can provide benefits for various parties: For the community, it can add insight into the tourism village development plan and participate in exploiting the potential of the village for the welfare of the community. For related agencies can add insight in planning the development and socializing the potential of tourist villages to the community outside the village. For the government as input in determining policies related to the development of tourist villages. The results of this service are counselling activities in the form of community service have been successfully carried out to the community of Kampung Bandar tourist area. The increase in community knowledge is known from the results of the discussion after extension the community.
The Influence of Current Ratio and Price to Book Value on Financial Distress Conditions in Tourism and Restaurant Hospitality Sub-Sector Service Companies Listed on the Indonesian Stock Exchange
Authors:   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Arifuddin Arifuddin , Safaruddin Safaruddin ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Hadisantoso Erwin ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Ramadhan Andi Muhamad Fuad ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Purnaman Si Made Ngurah ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Desriyani Desriyani ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Septriani Nur Rezky ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia, Nurhasanah Nurhasanah ,   Department of Accounting, Faculty of Economics and Business, Halu Oleo University, Indonesia
Published: December 2023

This research aims to determine the effect of current ratio and price to book value on financial distress in companies sub-sector services hotels, tourism and restaurants listed on the Indonesian Stock Exchange. There are 42 companies in Indonesia and the research sample is 10 companies. Through the Stratified Random Sampling sampling method. This study use method analysis linear multiple with use media software SPSS version 26. The results of the research show that current ratio and price to book value simultaneous influential positive and significant to financial distress in sub- sector companies hotels, tourism and restaurants listed on the Indonesian Stock Exchange. This matter means if current ratio and price to book value increase or decrease so influential in a way together to financial distress. Current ratio Partial influential positive and significant to financial distress in the company sub- sector services hotels, tourism and restaurants listed on the Indonesian Stock Exchange. This matter Because the more increasing mark current ratio then the more capable company for fund operational in pay obligation period short. Price to book value Partial influential negative and significant to financial distress in the company sub-sector services hotels, tourism and restaurants listed on the Indonesian Stock Exchange. This matter Because share company valued relatively cheap compared to mark the book, so company fail create mark for holder the shares.
Rabies elimination policy guidelines: Where do we stand?
Authors: Shenoy M Swathi , Santra Archismita , Giri Anjan Kumar
Published: December 2023

Introduction: Rabies is one of the Neglected Tropical diseases. India accounts for 35% of rabies-related human deaths globally. Despite effective preventive and control strategies, India hasn't been able to eliminate rabies. Methodology: A narrative review was done by comparing various policies and programmes related to rabies control and elimination in India and other countries, and the gaps persisting in the Indian guidelines and its implementation were assessed. Results: There are multiple gaps in the Indian programme implementation ranging from multiple stockouts of vaccines, unavailability of rabies immunoglobulin, and lack of a robust surveillance system to lack of refreshing training of the health staff. Recommendations: For effective implementation, the population should have increased awareness, with increased production and an effective supply chain of vaccines and immunoglobulins. There should also be a robust surveillance system with periodic refresher training of the health staff.
Depression and associated risk factors among geriatrics population in field practice areas of tertiary care institution in Unnao district of Uttar Pradesh
Authors: Kumar Abhishek , Kumar Aman , Kharya Pradip , Pachauri Rajat Kumar , Singh Aditi , Sapru Komudi
Published: December 2023

Background: Ageing is inevitable for any human being. According to census 2011, the population of over 60 years of age in India accounted 8% of the total population, as of 2016 it is 8.6% which is projected to increase to 20% by 2050. Aim & Objective: To estimate the prevalence of depression among geriatrics age group and to identify factors associated with depression among geriatrics age group. Material & Methods: It was a cross-sectional study conducted between April 2022 and September 2022. Total sample size was 138. Number of subjects to be sampled from each village was calculated by probability proportion to size (PPS). Finally using simple random sampling method, participants were selected from each village. Results: The majority of the participants were in between 60 and 65 years old (63.8% of the total), next 66 to 75 years old (26.8% of the total), and finally over 75 years old (9.4% of the total). The mean age of participants in the study was 65.06+6.60 years. The proportion of male participants in the study was 47.1%, and the proportion of female participants was 52.9%. In present study, it was found that 65.9% had depression among the geriatrics population. Conclusion: This study also portrays significant association with age group, marital status, occupation, type of family and smoking history among depression among geriatrics.
Burden of care on family caregivers of patients of gastrointestinal cancers in a tertiary care institute
Authors: Sharma Mohit , Devgun Priyanka , Sharma Ashwin
Published: December 2023

Background: Gastrointestinal tract cancers are one of the leading causes of morbidity and mortality globally and cause family members to become primary caregivers. Method: The observational cross- sectional study was conducted using a pretested questionnaire and BSFC short form scale on 156 primary family care givers of patients suffering from and seeking treatment for cancer of the gastrointestinal tract from June 2021 to May 2022 in a tertiary care institute. Result: Mean age of family caregiver was 48.6 (4.7) years and the majority were female 111 (71.1 %).  Average duration of primary care given was 2.62(1.24) years. 94 (60.2%) family care givers provided > 8hr duration of care. 103 (66%) of the family caregivers suffered from moderate burden, 39 (25%) from heavy burden and only 14 (8.97%) family caregivers considered burden as mild. Significant association was found between >8 hours of caregiving, caregiver having a comorbid illness, treatment outcome and financial distress borne during the course of treatment and burden of caregiving. Conclusion: Burden of caregiving in the family caregivers of cases of gastrointestinal cancer has the capacity to create ripples in the primary life domains of the caregiver and needs to be looked into.
Unnat Bharat Abhiyan: An Opportunity to participate in a National Program to Implement & Complement Family Adoption Program for Holistic Rural development
Authors: Raut Juhi M , Joshi Abhishek U
Published: December 2023

Medical education in India is predominantly based on Theoretical and bedside teaching. A significant reorientation is needed in medical education, to allow students to understand the grass root level social health dynamics. National Medical commission introduced Family Adoption program as a modality to address this issue to be implemented by all medical colleges for all students admitted from academic year 2022 onwards. The Unnat Bharat Abhiyan (UBA) is a flagship national program of Government of India for holistic rural development by engaging and enabling higher educational institutions to utilize their expertise for accelerating sustainable growth and development of rural India. The Medical Universities/colleges can participate in Unnat Bharat Abhiyan and utilize its platform for implementation of statutory Family adoption program. We developed a Model where in Health sciences Universities/colleges can leverage their expertise in Health care for benefit of adopted villages and Communities by nurturing their health based on our experience of implementing both Unnat Bharat Abhiyan & Family Adoption Program. We propose various measures in which Health sciences Universities/colleges can implement both programs in sync to complement each other towards common goal of welfare of adopted villages. We believe our model is feasible and can address complementary requirements of Unnat Bharat Abhiyan and Family adoption program and benefit all the stakeholders involved.
Similarities and Differences of Expression of Gene in Prokaryotic and Eukaryotic Cells: A Critical Review
Authors:   Department of Biotechnology, Adikavi Nannaya University, Rajahmundry 533 296, East Godavari District, Andhra Pradesh, India, DSRS Prakash , Mohan S Murali ,   Department of Biotechnology, Adikavi Nannaya University, Rajahmundry 533 296, East Godavari District, Andhra Pradesh, India, Mouli J Balaji Chandra ,   Department of Biotechnology, Adikavi Nannaya University, Rajahmundry 533 296, East Godavari District, Andhra Pradesh, India
Published: December 2023

This article is totally based on the literature review about expression of gene in prokaryotic and eukaryotic cells. Gene is the part of the DNA that is responsible for the formation of the genotype and then a phenotype. Gene can only be expressed in case of formation of protein. The process of the gene expression is accomplished in the two steps; Transcription and translation. Transcription is the process of the formation of the mRNA. Transcription proceeds in the three steps. In initiation step the RNA polymerase moves on the unwind DNA strand until the promoter sequence is reached, next is the elongation step in the newly synthesized RNA strand elongates, the process terminates as the RNA polymerase realize the termination sequence. After the mRNA is formed it is released into the cytoplasm without any alterations in case of prokaryotes, but in case of eukaryotes post transcriptional modifications takes place which include capping, tailing and splicing. Translation is the process of the formation of protein from mRNA. Translation proceeds in the four steps in which the t RNA is charged, the initiation complex is formed with Met-tRNA at the P site start codon is recognized after binding of the ribosomal subunits to mRNA, in elongation step the peptide bond is formed and the polypeptide chain grows, stop codons enters at the A site and thus the process is terminated. Post translational modications takes place which the initiation amino acid methionine is removed
Gastrointestinal Stromal Tumor of Esophageal Location: A Rare Case with Surgical Discussion. Case Report and Literature Review
Authors:   Department of Clinical Oncology, Oncologia D’Or – Aliança Hospital/Rede D’Or São Luiz Hospital Group, Leite Canguçu Augusto
Published: December 2023

Gastrointestinal stromal tumors (GISTs) are rare mesenchymal neoplasms. They arise from the intestinal wall and usually present as subepithelial neoplasms in the stomach and small intestine; however, they can appear anywhere in the gastrointestinal (GI) tract. Most of these tumors have mutations in KIT or platelet-derived growth receptor alpha (PDGFRA), while mutations in succinate dehydrogenase (SDH) or other genes are less frequent. New molecules have shown promising results in the therapy of these tumors.
The Physical Vacuum Models with Intrinsic Angular Momentum: From Vorticity of Maxwell’s Luminiferous Ether to Pseudomagnetism
Authors:   The State University of Management, Moscow, Russia, Boldyreva Liudmila Borisovna
Published: December 2023

In this work, the main milestones of the development of physical vacuum model with intrinsic angular momentum were considered. J. C. Maxwell was the first researcher who introduced this property in the physical vacuum for the mathematical description of electromagnetic oscillations and results of Faraday’s experiments with magnetic fields. The milestones of the development of Maxwell’s model are the following: the introduction by Planck, Einstein and Stern of atomic oscillators with so-called zero-point energy; the introduction by Feynman of virtual particles created by quantum objects; the introduction of pseudomagnetic interaction between spins by Abragam et al. The enriching of our knowledge about the physical vacuum characterized by intrinsic angular momentum lets us to explain the wave and inertial properties of quantum objects, to create a theory alternative to Special Relativity, to determine the conditions of generation of a process having superluminal speed (spin supercurrent), to determine the conditions of obtaining energy from the spin system of physical vacuum. In some cases, without taking into account this energy (based only on Newton’s laws) the violation of the principles of energy conservation takes place.
Application of social media for reference service delivery in academic libraries in Delta State, Nigeria
Authors: Tadaferua Eguono
Published: December 2023

This study investigated the application of social media for reference service delivery in academic libraries in Delta State, Nigeria. The objectives is to ascertain the kind of reference services offered, identify the facilities available for the application of social media, identify the social media reference librarians used in academic libraries in Delta State. and to identity the constraints to the application of social media by reference librarians. Four research questions guided the study. The descriptive survey design was used. A sample size of 12 respondents was used. The instrument used was the questionnaire. The data was analyzed using the frequency table and simple percentage. The findings revealed that amongst others that the two major types of reference service which are direct and indirect reference services are in used by the Delta State academic libraries, they already have the facilities such as internet, computers, and webcam that will enable them to apply social media as a tool in the provision of reference services in meeting the needs of library users, Facebook, MySpace, Twitter, WhatsApp and YouTube can be used for reference service delivery. Therefore this study recommends that the All the academic libraries that already have facilities such as computers, Internet, and webcam should incorporate social media tools in the reference section and it should be sustained in order to ensure continuity and usability in the provision of reference services and academic libraries should make sure that modalities are put in place for constant power supply, good network provision, and retraining of staff.
Relationship between digital attitudes of librarians and provision of virtual library services in federal university libraries in South-East and South-South, Nigeria
Authors: Njuku Sheila U. , Anunobi Chinwe V.
Published: December 2023

The study investigated the relationship between digital attitudes of librarians and provision of virtual library services in federal university libraries in South-Eastand South-South, Nigeria . A correlation research design was adopted for the study. The population of the study comprised 203 librarians in federal universities in South-East and South-South, Nigeria. A census sample design was used as the population was manageable. The instruments used for data collection was the questionnaire. Three research questions were answered and three null hypotheses were testedat 0.01 level of significance for the study. The Pearson’s product moment correlation coefficient (PPMCC) was used to answer the research questions and test the hypotheses. The findings of the study indicated that there is high positive relationship between academic librarians’ digital attitude and provision of virtual library services. It also indicated a significant relationship between digital attitude of academic librarians’ and provision of virtual library services. The study recommended a continuous training and retraining of librariansto ensure a continuous development of skills necessary to operate in a virtual environment and to support positive attitude that will lead towards meeting up with the digital technological demands.
The Influence of Motivation and Discipline on The Performance of Civil Servants on The Regional Education Services of North Sulawesi Province
Authors: Kandow Christia M. , Dilapanga Abdul Rahman , Pangkey Itje
Published: December 2023

The aim of this research is to test, describe and analyze: a) The relationship between motivation (X1) and performance (Y); b) The relationship between discipline (X2) and performance (Y); c) Simultaneous relationship between motivation (X1) and discipline (X2) on performance (Y); d) the influence of motivation (X1) on performance (Y); e) the influence of discipline (X2) on performance (Y), and f) the influence of motivation (X1) and discipline (X2) simultaneously on the performance (Y) of Civil Servants (PNS) of the North Sulawesi Province Regional Education Service. This research uses quantitative research methods with a sample size of 95 Civil Servants. Data was obtained through a questionnaire with a Likert scale. The results of the research show that 1) There is a significant relationship between employee motivation and discipline at the Regional Education Office of North Sulawesi Province; 2) There is a significant influence on employee motivation and discipline at the Regional Education Office of North Sulawesi Province; 3) The contribution of motivation (X1) and discipline (X2) together to performance (Y) is 34.6%; 4) The variance of the performance variable (Y) can be influenced by the variance of the motivation (X1) and discipline (X2) variables together; 5) Motivation (X1) on performance (Y) and discipline (X2) on performance (Y) separately have a significant influence; 6) The discipline variable (X2) influences the performance variable (Y) more than the motivation variable (X1).
Morus alba; A Ray of Hope for Psychiatric Illnesses
Authors: Siddiq Dr. Afshan , Soofi Sidra Mohiuddin
Published: December 2023

Purpose: Over the years, plants have been used in treatment of various health ailments. Morus alba also known as White Mulberry is a deciduous tree which belongs to family Moraceae. Mulberry is rich in antioxidants such as hydrophobic flavonoids, polyphenols, carotenoids, vitamin A, C and E.

Materials and Methods: This study analyses the central nervous system activities including memory enhancement, learning abilities, changes in behavior, cognition, anxiety and depression. These effects will be studied on experimental mice, which will be distributed in control and test groups. Aqueous fruit extract prepared by Maceration extraction will be given to test group in three different doses per oral over a time period of 30 days, whereas control will be given water for injection for same duration.

Findings: Afterwards, changes in aforementioned effects will be observed to determine the pharmacological effects of taken fruit. The obtained results suggest an antidepressant like effect of mulberry in the initial two weeks of dosing. Afterwards it shows anxiolytic effect at higher doses.

Implications to Theory, Practice and Policy: All these tests can be repeated weekly while dosing the animals daily for 90 days for chronic toxicity analysis. Furthermore, we can add a brain biopsy/histopathology to evaluate the changes in chemical neurotransmitters.
OS RUMOS DO SUPREMO TRIBUNAL FEDERAL: ENTRE A PROTEÇÃO DA DEMOCRACIA E O ATIVISMO JUDICIAL
Authors: Omena Vasconcellos Trennepohl Anna Karina , Kazumi de Lorena Infante Vieira Kobayashi Eduardo
Published: December 2023

Este artigo propõe-se a discorrer sobre as formas jurídicas do autoritarismo na contemporaneidade e examinar os riscos democráticos de uma interpretação judicial sem limites. Para tanto, é necessário enveredar-se pelo caminho da teoria do Direito, no intuito de apresentar um panorama histórico e doutrinário daquilo que se denomina por degeneração do Direito. Ao mesmo tempo, busca-se demonstrar o importante papel das cortes constitucionais em democracias frágeis, como a brasileira. Por fim, no intuito de tornar este estudo teórico aplicável a um caso concreto, reflete-se acerca dos entendimentos expostos pelos ministros do Supremo Tribunal Federal - STF no julgamento das Ações Declaratórias de Constitucionalidade – ADCs n. 43, 44 e 54, que trataram da possibilidade da execução provisória da pena, bem como sobre a proposta de Emenda à Constituição que autoriza a revisão as decisões do Supremo Tribunal Federal pelo Poder Legislativo. Para o desenvolvimento deste artigo, a metodologia adotada foi o levantamento e análise bibliográfica e o estudo de caso concreto, associada a uma pesquisa atenciosa da jurisprudência.
CHROMOSOMAL ABERRATIONS IN LEUKOCYTE METAPHASES OF LEPROSY PATIENTS UNDER DAPSONE THERAPY
Authors: BEIGUELMAN B. , PISANI R. C. B.
Published: December 2023

Chromosome analyses were made on leukocyte metaphases of 18 leprosy patients who were ingesting daily doses of 50 mg or 100 mg of DDS and of 40 healthy individuals used for control. These analyses have shown that the proportion of numerical chromosomal aberrations in the leukocyte metaphases of the leprosy patients did not differ significantly from that observed in the cells of the controls. In contrast, the frequency of cells with chromatid or chromosome breaks and gaps was significantly increased in the leukocytes of leprosy patients. Multiple regression analysis applied to the data recorded has shown that the increase of breaks and gaps in the chromosomes of leprosy patients can not be attributed to age, years under sulfonetherapy or to concentration of DDS in blood.
Observações sobre o emprego da rifampicina em hansenianos aparentemente sulfono-resistentes
Authors: BELDA W. , MENDES J. P. , MARGARIDO L. C. , MARTINEZ E. A. L. W.
Published: December 2023

Os autores relatam os resultados obtidos com a rifampicina no tratamento de 10 pacientes de hanseníase virchowiana, clinicamente resistentes à sulfonoterapia. São apresentadas as observações clínicas, os exames baciloscópicos, histopatológicos, de sangue, urina e as provas de função hepática. Os resultados significativos levam os autores a confirmar a ação do medicamento e sua indicação como de escolha nos casos de hanseníase sulfono-resistente.
Hanséniase, maladie tropicale originelle. Diversité d'évolution clinique salon le degré d'immunité ancestrale des populations régionales (Contribution à la pathologie géographique)
Authors: PUPO JOÃO DE AGUIAR
Published: December 2023

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Estudios inmunolágicos en pacientes de lepra indeterminada
Authors: FLIESS ENRIQUE L. , HERRERA MIGUEL DE , CAROSELLA EDGARDO D. , BALIA LUIS M. , CARDAMA JOSE E. , GATTI JUAN C.
Published: December 2023

Se efectuó un estudio longitudinal de un grupo de pacientes de lepra indeterminada, realizando dos tandas de estudios inmunológicos (leprominorreacción y test de formación de rosetas E) y clínicos en 1973 y 1977 respectivamente. Se observó una diferencia significativa en los estudios de rosetas E, entre los pacientes lepromino-positivos y los lepromino-negativos (p < 0.01) en 1973, incrementandose la diferencia en 1977 (p <0.001). Coincidentemente con esto hube una relación entre la respuesta inmunológica y la evolución hacia formas clínicas polares de la enfermedad, pudiendo existir también una influencia en esta evolución de la presencia o no de tratamiento especifico. El viraje de leprominorreaciones de pacientes con valores normales de rosetas E en 1973 habla de una mayor sensibilidad del test in vitro como pronóstico.
A non-stigmatizing Bible
Authors: ROTBERG Abrahão
Published: December 2023

The "tsará-ath" of the Hebrew Books, translated as "Lepra" in the Greek "Septuaginta" Bible was a ritual defilement based on various skin and scalp lesions and on blemishes, probably mold, on garment, leather, walls and stones. The previous appellation ("Lepra") of those lesions changed to "Vitiligo", "Psoriasis"' "Tinea", etc. but is still current for Hanseniasis (Hansen's disease), whose signs cannot be found in the Bible. This historical linguistic confusion is an important cause of serious psycho-social, medical and preventive problems in Christian endemic countries, spreading to nonChristian areas. The last known example is that of the highlands of Papua New Guinea, where Hanseniasis was "a disease like the others", until the arrival of Western influences and religious missions, resulting in stigmatization and ostracization of patients and their families. To ensure that evangelization should neither be accompanied by discrimination nor by misinformation about the disease, some modern Bible translations are no longer using the word "Leprosy". This term has also been abandoned by the Brazilian Ministries of Health and of Social Welfare, as well as by the United States Public Health Service, and by the government of Portugal.
A "tecnicamente impossível educação sobre lepra" - e uma advertência ao mundo endêmico
Authors: Rotberg Abraão
Published: December 2023

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Genética na Hanseníase
Authors: BEIGUELMAN BERNARDO
Published: December 2023

As linhas de pesquisa que foram exploradas para avaliar a importância da constituição genética humana na determinação da resistência e suscetibilidade ao Mycobacterium leprae foram revistas no presente trabalho. O autor faz uma análise critica das investigações sobre recorrência familial da hanseníase, associação familial dos tipos polares de hanseníase, riscos de contágio intrafamilial, distribuição populacional da hanseníase, concordância das manifestações de hanseníase em pares de gêmeos, reação de Mitsuda em famílias e em pares de gêmeos, reação in vitro dos macrófagos do sangue contra o M. leprae morto, genealogias selecionadas, dermatóglifos, associações entre polimorfismos genéticos e hanseníase e aberrações cromossômicas.
Efeito da terapêutica sulfônica na sobrevida dos doentes de hanseníase
Authors: MARLET JOSE MARIA
Published: December 2023

Utilizando a técnica das tábuas de sobrevida modificadas para seguimento de moléstias crônicas, estudam-se as probabilidades acumuladas de sobrevida de 5.000 doentes de hanseníase da era pressulfônica e 5.000 da era sulfônica. Foram calculadas as probabilidades acumuladas de sobrevida, segundo a modalidade do diagnóstico inicial e a idade do paciente por ocasião do mesmo. Observou-se que:  a terapêutica sulfônica aumenta as probabilidades acumuladas de sobrevida dos doentes de hanseníase  os virchovianos são os que mais se beneficiam, em termos de sobrevida„ da terapêutica sulfônica e  os acréscimos de sobrevida proporcionados pelas sulfonas aos tuberculóides são, praticamente, os mesmos que os obtidos pelos doentes de hanseniase indeterminada.
II Congresso Brasileiro de Hansenologia
Authors: ROTBERG Abrahão
Published: December 2023

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Chiamiamola hanseniasi
Authors: BARUFFA Giovanni
Published: December 2023

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La función hepática através del espectro clinico de la hanseniasis
Authors: Pacin Ana , Fliess Enrique L. , Llorente Berta E
Published: December 2023

Se estudie la función hepática en 100 pacientes hansenianos agrupados segtin la clasificación espectral y la presencia o no de episodios reaccionales del siguiente modo; pacientes quiescentes: 20 LL, 13 BL, 7 BB, 9 BT, 12 TT. Pacientes reaccionales: 12 LL, 10 BL, 7 BB, 5 BT, 5 TT. Como grupo testigo se estudiaron 10 individuos sanos no contactantes con pacientes hansenianos y sin antecedentes de patología hepática. Los resultados obtenidos muestran una hiperproteinemia a expensas de las globulinas sin disminución de albúmina en todas las formas clínicas de la hanseniasis, reaccionales y quiescentes, y un aumento de la actividad enzimática sérica de GPT, GOT y fosfatasa alcalina en los pacientes reacciónales. Estos incrementos de la actividad enzimática caracterizan un daño hepatocelular leve, en que la bilirruhinemia y la prueba de turbidez del timol no presentan alteraciones. Se discuten los mecanismos fisiopatológicos causantes de estas alteraciones, postulándose su vinculación con fenómenos de hipersensibilidad a tipo III y IV.
Thanks to time, Newsweek, Siete Dias, o Cruzeiro, and others
Authors: ROTBERG Abrahão
Published: December 2023

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Um caso pouco comum de erythema nodosum leprosum
Authors: PETRI Valeria
Published: December 2023

No presente trabalho descreve-se e comenta-se uma manifestação pouco comum de erythema nodosum leprosum (ENL) em uma mulher de 24 anos, cuja história e quadro clínico não sugeriam hanseníase, mas lupus eritematoso sistêmico em fase de agudização. O diagnóstico de ENL só foi conseguido quando se demonstrou a presença de bacilos AAR nas lesões ulceradas.
Fagocitosis y lisis de Candida Albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos de pacientes hansenianos
Authors: Fliess Enrique L. , Comesana Guillermo , Carrara Roberto C. , España Alberto
Published: December 2023

Se estudió la fagocitosis y lisis de Candida albicans y Candida pseudotropicalis por polimorfonucleares neutrófilos humanos, en 43 pacientes hansenianos. (19 virchowianos quiescentes, 12 virchowianos reaccionales y 12 tuberculoides quiescentes) y 15 testigos sanos. El propósito de este estudio fué determinar si los polimorfonucleares neutrófilos de pacientes hansenianos presentaban alteraciones de sus sistemas enzimáticos mieloperoxidasa-dependientes (investigado mediante lisis de Candida albicans) y mieloperoxidasa independientes (investigado mediante lisis de Candida pseudotropicalis). Los resultados indican que los neutrófilos de los pacientes hansenianos tienen una actividad candidicida similar a la de los neutrófilos de testigos sanos, (p > 0.2) en sus sistemas mieloperoxidasa dependiente e independiente. La actividad de estos sistemas enzimáticos es también similar en todas las formas clínicas de hanseniasis (p > 0.3).
Meningoencefalite por Cryptococcus neoformans como complicação de insuficiência vascular arteriosclerótica em hanseníase virchowiana
Authors: Fleury R. N. , Opromolla Diltor Vladimir Araújo , Tonello C. S.
Published: December 2023

E apresentado o caso de um paciente de cor branca, com 39 anos de idade, portador de hanseníase virchowiana, que nos últimos três anos de vida apresentou uma seqüência de complicações, incluindo surtos subentrantes de reação hansênica (eritema nodoso), gangrena isquêmica de pé esquerdo, amputação do membro inferior esquerdo, acidente vascular isquêmico cerebral, e quadro final infeccioso com sinais de comprometimento meníngeo e hipertensão intracraniana. A autópsia demonstrou um paciente virchowiano com grau avançado de arteriosclerose para a idade, principalmente no cérebro e segmento distal da aorta e suas ramificações, com trombose de aorta terminal, iliacas primitivas e renais ao lado de trombose venosa em estadias variados de organização da femural e ilíaca esquerdas, e segmento distal da cava inferior. O encéfalo mostrava amolecimentos isquêmicos em organização, e difuso comprometimento meningoencefálico por reação granulomatosa à Cryptococcus neoformans. E discutido o encontro de comprometimento arteriosclerótico intenso e precoce com trombose e insuficiência circulatória em dois territórios arteriais importantes, bem como as eventuais relações dos fenômenos de trombose arterial e venosa com os episódios subentrantes de eritema nodoso hansênico. A torulose é considerada uma intercorrência final, onde os fungos atingiram o S.N.C. a partir de lesões pulmonares prévias. Chamou atenção a presença de vasculites proliferativas no espaço subaracnóideo, reacionais ao processo granulomatoso, e que devem ter agravado a situação de isquemia cerebral.
Bacilos álcool-ácido-resistentes na água do lago do aleixo
Authors: SALEM Júlia Ignez , FONSECA Ozório J. M.
Published: December 2023

Relata-se a presença de bacilos álcool-ácido-resistentes na água do lago do Aleixo, local habitado por uma comunidade de hansenianos. O ambiente físico-químico do lago é descrito em um ciclo anual e procura-se relacionar a qualidade da água à maior ou menor freqüência de micobactérias detectadas. Propõe-se o prosseguimento do trabalho nesse sistema lacustre, direcionado mais especificamente para a caracterização desses microrganismos e determinação de sua viabilidade.
Imunologia e hanseníase
Authors: AZULAY R. D.
Published: December 2023

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Conversion of the C3 component of complement in sera of hanseniasis patients
Authors: Kliemann Teresa A. E. , Martinez Ednir L. W. , Irulegu Ione , Souza Zóia W. Telles de , Cavalcanti Zélia Maria de O.I
Published: December 2023

The levels of total C3 (native C3 plus its degradation products) and the degree of conversion of native C3 into its breakdown products were studied in sera of Virchowian (V), tuberculoid (T), indeterminate (I), and Virchowian with erythema nodosum Hansenicum (ENH) patients. Sera from normal individuals (N) were also analysed. While the levels of total C3 were not significantly different among the groups, the percentage of conversion of C3 into its degradation products was significantly higher in V and ENH sera. The activation of the complement system and the involvement of immune complexes (IC) are discussed.
Alteración de la inminidad mediada por células frente a Mycobacterium leprae y mycobacterium marinum en pacientes hansenianos
Authors: FLIESS Enrique L. , ORTIZ Maria C. , CORN Juan
Published: December 2023

Se estudió la inmunidad mediada por células (IMC) frente a derivados proteicos purificados de Mycobacterium leprae, Mycobacterium tuberculosis, Myco- bacterium avium y Mycobacterium marinum. Se efectuaron tests cutineos de  hipersensibilidad retardada einhibicién de la migración de leucocitos in vitro en 44 pacientes hansenianos (20 virchowianos quiescentes, 13 virchowianos reaccionales y 11 tuberculoides) y en 15 testigos sanos. Se observóuna alteración de la inhibicifin de la migración de leucocitos y de la hipersensibilidad cutinea frente a M. leprae y M. marinum en los pacientes vircho- wianos, quiescentes y reaccionales. La respuesta de la IMC frente a todos los antigenos micobacterianos se encontró aumentada en los pacientes tuberculoides, y se observó una respuesta débil frente a M. leprae y M. marinum en los controles sanos. Los  resultados obtenidos muestran una estrecha correlación entre la IMC frente a M. leprae y M. marinum en todos los casos, la cual podria expresar reactividad cruzada entre ambos antígenos.
Tendon-test del nervio tibial en el mal de hansen
Authors: Blank A. , Wolf J. , Gonén B. , Schochina M. , Sheskin J.
Published: December 2023

De un total de 17 enfermos hansenianos examinados por Tendon-Test, se obtuvo respuesta claramente patológica en 9. En otros 4 no hubo respuesta alguna, y cabe suponer que ello se debe al serio estado patológico del nervio. El total de respuestas patológicas llegaría asi a 76,5% (13 enfermos). En otros dos pacientes la respuesta fue limítrofe, y se los clasificó junto con los dos pacientes que dieron respuesta normal, alcanzando asi el porcentaje a 23,5% (4 enfermos). A fin de verificar si los nervios tibiales son atacados al mismo tiempo que los ulnares y medianos, se recomienda practicar este método no traumático en un número superior de enfermos, y en otro ambiente socio-geográfico.