bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembrolizumab for treatment of progressive multifocal leukoencephalopathy in primary immunodeficiency and/or hematologic malignancy: a case series of five patients
Authors: Volk Timo , Warnatz Klaus , Marks Reinhard , Urbach Horst , Schluh Gisela , Strohmeier Valentina , Rojas-Restrepo Jessica , Grimbacher Bodo , Rauer Sebastian
Published: July 2021

Progressive multifocal leukoencephalopathy is a rare opportunistic infection of the brain by John Cunningham polyomavirus in immune-compromised patients. In cases where no overt option for immune reconstitution is available [e.g., in patients with primary immunodeficiency (PID)], the disease is lethal in the majority of patients. Immune checkpoint inhibition has been applied in recent years with mixed outcomes. We present four novel patients and the follow-up of a previously published patient suffering from progressive multifocal leukoencephalopathy (PML) due to PID and/or hematologic malignancy who were treated with the immune checkpoint inhibitor pembrolizumab. In two patients with PID, symptoms improved and stabilized. One patient died because of worsening PML another of intracranial hemorrhage which was unrelated to PML or its treatment with pembrolizumab. The fifth patient suffered from PID and died of a pre-existing immune dysregulation, possibly exacerbated by pembrolizumab. The long-term follow-up of the first patient provides support for therapeutic decisions during this therapy and is the longest published clinical course of a patient with checkpoint inhibition for PML. We conclude that pembrolizumab can control PML symptoms long term in a subgroup of patients with PID, in our cases for 21 and 36 months. However, therapy must be started early because symptoms are only partially reversible. In light of severe adverse events, application of pembrolizumab is only justified if the prognosis for the individual patient is very poor.
Regular football training down-regulates miR-1303 muscle expression in veterans
Authors: Mancini A. , Vitucci D. , Orlandella F. M. , Terracciano A. , Mariniello R. M. , Imperlini E. , Grazioli E. , Orrù S. , Krustrup P. , Salvatore G. , Buono P.
Published: July 2021

Purpose

Regular exercise affects the expression of several genes, proteins and microRNAs (miRNAs) in time- and intensity-dependent manner promoting longevity. We previously identified from GeneChip Array analysis several differentially expressed genes and miRNAs in muscle from veteran football players (VPG) compared to active untrained elderly subjects (CG); here we focussed on miRNA-1303 (miR-1303). The aims of the present research were: to analyse the effects of football training on the expression of miR-1303 and to identify its putative target involved in the longevity pathways in skeletal muscle from VPG compared to CG.

Methods

RNA samples from 12 VPG and 12 CG muscle biopsies were used to validate miR-1303 expression. Crossing four different bioinformatic algorithms, we identified 16 putative targets of miR-1303; from these, BAG-2, KLHL7 and KBTBD6 were chosen for further validation by Western blot analysis in LHCN-M2 human myoblasts transiently transfected with miR-1303.

Results

Football training down-regulates miR-1303 expression in muscle from VPG compared to CG and the expression of BAG-2, a chaperon protein involved in the autophagy pathway, inversely correlated to overexpression of miR-1303 in a time-dependent manner, indicating that it is a miR-1303 potential target.

Conclusions

This is the first report, to our knowledge, describing miR-1303 regulation in skeletal muscle by football training and the identification of a target protein, BAG-2, involved in the autophagy pathway. This result contributes to the enlargement of knowledge on the molecular mechanisms linking football training, autophagy and longevity.
Grading of invasive breast carcinoma: the way forward
Authors: van Dooijeweert C. , van Diest P. J. , Ellis I. O.
Published: July 2021

Histologic grading has been a simple and inexpensive method to assess tumor behavior and prognosis of invasive breast cancer grading, thereby identifying patients at risk for adverse outcomes, who may be eligible for (neo)adjuvant therapies. Histologic grading needs to be performed accurately, on properly fixed specimens, and by adequately trained dedicated pathologists that take the time to diligently follow the protocol methodology. In this paper, we review the history of histologic grading, describe the basics of grading, review prognostic value and reproducibility issues, compare performance of grading to gene expression profiles, and discuss how to move forward to improve reproducibility of grading by training, feedback and artificial intelligence algorithms, and special stains to better recognize mitoses. We conclude that histologic grading, when adequately carried out, remains to be of important prognostic value in breast cancer patients.
Decompression of the greater occipital nerve improves outcome in patients with chronic headache and neck pain — a retrospective cohort study
Authors: Eskilsson Anja , Ageberg Eva , Ericson Hans , Marklund Niklas , Anderberg Leif
Published: July 2021

Background

Compression of the greater occipital nerve (GON) may contribute to chronic headache, neck pain, and migraine in a subset of patients. We aimed to evaluate whether GON decompression could reduce pain and improve quality of life in patients with occipital neuralgia and chronic headache and neck pain.

Methods

In this retrospective cohort study, selected patients with neck pain and headache referred to a single neurosurgical center were analyzed. Patients (n = 22) with suspected GON neuralgia based on nerve block or clinical criteria were included. All patients presented with occipital pain spreading frontally and to the neck in various degree. Surgical decompression was performed under local anesthesia. Follow-up was made by an assessor not involved in the treatment of the patients, by telephone 2–5 years after the surgical procedure and an interview protocol was used to collect information. The data from the follow-up protocols were then analyzed and reported.

Results

When analyzing the follow-up protocols, decreased headache/migraine was reported in 77% and neck pain was reduced in 55% of the patients.

Conclusions

Decompression of GON(s) may reduce neck pain and headache in selected patients with persistent headache, neck pain, and clinical signs of GON neuralgia. Based on the limitations of the present retrospective study, the results should be considered with caution.
Psychotropic drug-induced hyponatremia: results from a drug surveillance program–an update
Authors: Seifert Johanna , Letmaier Martin , Greiner Timo , Schneider Michael , Deest Maximilian , Eberlein Christian K. , Bleich Stefan , Grohmann Renate , Toto Sermin
Published: July 2021

Hyponatremia (HN) is the most common electrolyte imbalance (defined as a serum sodium concentration Na(S) of  < 130 mmol/l) and often induced by drugs including psychotropic drugs. AMSP (Arzneimittelsicherheit in der Psychiatrie) is a multicenter drug surveillance program that assesses severe or unusual adverse drug reactions (ADRs) occurring during treatment with psychotropic drugs. This study presents data from 462,661 psychiatric inpatients treated in participating hospitals between 1993 and 2016 and serves as an update of a previous contribution by Letmaier et al. (JAMA 15(6):739–748, 2012). A total of 210 cases of HN were observed affecting 0.05% of patients. 57.1% of cases presented symptomatically; 19.0% presented with severe symptoms (e.g., seizures, vomiting). HN occurred after a median of 7 days following the first dose or dose increase. Incidence of HN was highest among the two antiepileptic drugs oxcarbazepine (1.661% of patients treated) and carbamazepine (0.169%), followed by selective serotonin-norepinephrine reuptake inhibitors (SSNRIs, 0.088%) and selective serotonin reuptake inhibitors (0.071%). Antipsychotic drugs, tricyclic antidepressants, and mirtazapine exhibited a significantly lower incidence of HN. The risk of HN was 16–42 times higher among patients concomitantly treated with other potentially HN-inducing drugs such as diuretic drugs, angiotensin-converting-enzyme inhibitors, angiotensin II receptor blockers, and proton pump inhibitors. Female SSNRI-users aged  ≥ 65 years concomitantly using other HN-inducing drugs were the population subgroup with the highest risk of developing HN. The identification of high-risk drug combinations and vulnerable patient subgroups represents a significant step in the improvement of drug safety and facilitates the implementation of precautionary measures.
Caries status of first-born child is a predictor for caries experience in younger siblings
Authors: Grieshaber Andreina , Haschemi Asin Ahmad , Waltimo Tuomas , Bornstein Michael M. , Kulik Eva M.
Published: July 2021

Objectives

This study analysed if children of families in need of dental interventions can be identified by using the caries status of the first-born child as a predictor for caries in younger siblings of the same family.

Material and methods

All children aged 4 to 15 years, i.e. 13,596 children, visiting a compulsory school in the canton of Basel-Stadt, Switzerland, during the school year 2017/2018 were analysed. Total caries experience and untreated carious lesions at time of examination were recorded as well as a subset of socioeconomic factors such as gender, age, nationality, birth order and the family’s place of residence.

Results

A total of 6738 schoolchildren who had at least one sibling of school age could be included. Differences in caries experience and the presence of active carious lesions were found for age, nationality and place of residence but not for gender or birth order. Younger siblings had odds of having a history of caries 3.7 times higher (95% confidence interval: 3.0–4.4) and odds of having active carious lesions 3.5 times higher (95% confidence interval: 2.6–4.7) if the eldest child in the family already had caries.

Conclusion

Caries could be shown to be family-dependent. Younger siblings had a more than three-fold higher risk for caries if the first-born child already had carious lesions.

Clinical relevance

Based on these results, the caries status of the first-born child could be used as a potential indicator to detect vulnerable families and to initiate targeted preventive measures.
Seismic behavior of precast reinforced concrete column-to-foundation grouted duct connections
Authors: Hofer Lorenzo , Zanini Mariano Angelo , Faleschini Flora , Toska Klajdi , Pellegrino Carlo
Published: July 2021

The paper shows the results of an experimental campaign aimed at investigating the cyclic behavior of a column-to-foundation joint for precast concrete elements. The tested connection is realized adopting corrugated steel ducts embedded into the foundation, in which column protruding rebars are anchored by grouting high performance mortar. The experimental program consists in testing six full-scale reinforced concrete square-section columns subject to quasi-static cyclic lateral load with a constant axial compression. A preliminary series of bond tests was carried out to define some experimental variables, i.e., longitudinal rebar diameter and anchorage length. Results of the precast joints are compared with those of two reference cast-in-place specimens with the same geometric characteristics, showing similar hysteretic behavior, energy dissipation and ductility values. Lastly, the plastic hinge height is computed for all the specimens based on experimental concrete strains, and compared to current codes formulations.
Ice giant system exploration within ESA’s Voyage 2050
Authors: Fletcher Leigh N. , Helled Ravit , Roussos Elias , Jones Geraint , Charnoz Sébastien , André Nicolas , Andrews David , Bannister Michele , Bunce Emma , Cavalié Thibault , Ferri Francesca , Fortney Jonathan , Grassi Davide , Griton Léa , Hartogh Paul , Hueso Ricardo , Kaspi Yohai , Lamy Laurent , Masters Adam , Melin Henrik , Moses Julianne , Mousis Oliver , Nettleman Nadine , Plainaki Christina , Schmidt Jürgen , Simon Amy , Tobie Gabriel , Tortora Paolo , Tosi Federico , Turrini Diego
Published: July 2021

Of all the myriad environments in our Solar System, the least explored are the distant Ice Giants Uranus and Neptune, and their diverse satellite and ring systems. These ‘intermediate-sized’ worlds are the last remaining class of Solar System planet to be characterised by a dedicated robotic mission, and may shape the paradigm for the most common outcome of planetary formation throughout our galaxy. In response to the 2019 European Space Agency call for scientific themes in the 2030s and 2040s (known as Voyage 2050), we advocated that an international partnership mission to explore an Ice Giant should be a cornerstone of ESA’s science planning in the coming decade, targeting launch opportunities in the early 2030s. This article summarises the inter-disciplinary science opportunities presented in that White Paper [1], and briefly describes developments since 2019.
Study on the cohesive edge crack in a square plate with the cohesive element method
Authors: Kellner Leon , Lu Wenjun , Ehlers Sören , Høyland Knut V.
Published: July 2021

The size of the fully developed process zone (FDPZ) is needed for the arrangement of displacement sensors in fracture experiments and choosing element size in numerical models using the cohesive element method (CEM). However, the FDPZ size is generally not known beforehand. Analytical solutions for the exact FDPZ size only exist for highly idealised bodies, e.g. semi-infinite plates. With respect to fracture testing, the CEM is also a potential tool to extrapolate laboratory test results to full-scale while considering the size effect. A numerical CEM-based model is built to compute the FDPZ size for an edge crack in a finite square plate of different lengths spanning several magnitudes. It is validated against existing analytical solutions. After successful validation, the FDPZ size of finite plates is calculated with the same numerical scheme. The (FDPZ) size for finite plates is influenced by the cracked plate size and physical crack length. Maximum cohesive zone sizes are given for rectangular and linear softening. Further, for this setup, the CEM-based numerical model captures the size effect and can be used to extrapolate small-scale test results to full-scale.
The Impact of COVID-19 on Anxiety and Worries for Families of Individuals with Special Education Needs and Disabilities in the UK
Authors: Sideropoulos V. , Dukes D. , Hanley M. , Palikara O. , Rhodes S. , Riby D. M. , Samson A. C. , Van Herwegen J.
Published: July 2021

COVID-19 has affected people across the world. The current study examined anxiety and worries during the first UK national lockdown in March 2020. Parents (n = 402) reported on their own anxiety and worries as well as that of their son/daughter with Special Education Needs and Disabilities (SEND) and typically developing (TD) child (n = 186) at three time points. Although both groups showed increased anxiety across the three time points, levels of anxiety in the SEND group, but not the TD siblings, were predicted by awareness about COVID-19. In addition, worries differed between the groups showing that COVID-19 impacts the wellbeing of those with SEND differently to that of their TD siblings.
Self-lubricating triboactive (Cr,Al)N+Mo:S coatings for fluid-free applications
Authors: Bobzin K. , Brögelmann T. , Kalscheuer C. , Thiex M.
Published: July 2021

Within this study, self-lubricating and triboactive (Cr,Al)N+Mo:S coatings were developed and investigated for the deposition on components in a low-temperature physical vapor deposition (PVD) hybrid process. Therefore, direct current magnetron sputtering (dcMS) and high power pulse magnetron sputtering (HPPMS) PVD were combined by using an industrial coating machine. Hereby, it was possible to deposit dense and smooth triboactive, self-lubricating nitride coatings with different chemical compositions and architectures on 16MnCr5E samples. Two coating architectures, a matrix monolayer and a graded coating structure, were developed to evaluate the effect on the tribological behavior. The morphology and coating thickness were analyzed by means of scanning electron microscopy (SEM). Furthermore, the indentation hardness and modulus of indentation as well as the compound adhesion between substrate materials and coating were analyzed. Tribological analyses of (Cr,Al)N+Mo:S-coated and uncoated samples were conducted under fluid-free friction regime at room temperature T = (20 ± 3) °C, a velocity v = 0.1 m/s and a distance s = 1000 m by varying the Hertzian contact pressure from 400 MPa ≤ pH ≤ 1300 MPa against steel counterparts, 100Cr6, in a pin-on-disk (PoD) tribometer. The graded coating architecture of (Cr,Al)N+Mo:S enabled a significant wear and friction reduction. Furthermore, Raman analyses prove the formation of solid lubrication tribofilm containing MoS2, MoO3 MoO2 and MoxOy at the toplayer of a graded (Cr,Al)N+Mo:S coating, which are responsible for the improved tribological behavior.
Exploration of the temperature-dependent correlations present in the structural, morphological and electrical properties of thermally reduced free-standing graphene oxide papers
Authors: Ramamoorthy Harihara , Buapan Kanokwan , Chiawchan Tinna , Thamkrongart Krongtham , Somphonsane Ratchanok
Published: July 2021

We report on a corroborative study of the structural, morphological and electrical property alterations of free-standing graphene oxide (GO) papers subject to thermal reduction. Structural analysis performed using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and Raman techniques prove that the onset of major structural changes, characterized by removal of oxygen functionalities, occur in the 200–300 °C temperature range. The results are corroborated with related morphological changes observed using Scanning electron microscopy (SEM) and Atomic force microscopy (AFM) imaging. Elemental analysis shows the GO paper reduced at 600 °C to contain an 85 wt. % carbon content and a remnant oxygen level of 13.31 wt. %. At the highest reduction temperatures, we see evidence of vacancy-type defects impeding the overall effectiveness of the reduction process. Detailed electrical resistance measurements and current–voltage (I-V) profiling conducted using four-point probe method reveals a several orders of magnitude drop in the sample resistance once the reduction temperature exceeds 200 °C, in good agreement with the structural and morphological changes. The fundamental insights revealed through these studies will be important for future applications where the electrical and mechanical properties of free-standing GO and reduced graphene oxide (rGO) are exploited in practical devices.

Graphical abstract
Linking categorical models for prediction of pleasantness score using individual predictions of sweetness and creaminess: An advancement of categorical modeling
Authors: Leohr Jennifer , Kjellsson Maria C.
Published: July 2021

The aim of this work was to develop and evaluate approaches of linked categorical models using individual predictions of probability. A model was developed using data from a study which assessed the perception of sweetness, creaminess, and pleasantness in dairy solutions containing variable concentrations of sugar and fat. Ordered categorical models were used to predict the individual sweetness and creaminess scores and these individual predictions were used as covariates in the model of pleasantness response. The model using individual predictions was compared to a previously developed model using the amount of fat and sugar as covariates driving pleasantness score. The model using the individual prediction of odds of sweetness and creaminess had a lower variability of pleasantness than the model using the content of sugar and fat in the test solutions, which indicates that the individual odds explain part of the variability in pleasantness. Additionally, simultaneous and sequential modeling approaches were compared for the linked categorical model. Parameter estimation was similar, but precision was better with sequential modeling approaches compared to the simultaneous modeling approach. The previous model characterizing the pleasantness response was improved by using individual predictions of sweetness and creaminess rather than the amount of fat and sugar in the solution. The application of this approach provides an advancement within categorical modeling showing how categorical models can be linked to enable the utilization of individual prediction. This approach is aligned with biology of taste sensory which is reflective of the individual perception of sweetness and creaminess, rather than the amount of fat and sugar in the solution.
Earnings management in state-owned enterprises: bringing publicness back in
Authors: Ruggiero Pasquale , Sorrentino Daniela , Mussari Riccardo
Published: July 2021

Financial accountability is a major issue for State-owned Enterprises (SOEs) especially because of the large amount of public resources invested in them and the social relevance of their performance. In the awareness that the public interest is increasingly pursued in abstract arenas, the investigation of accounting should be anchored to conceptual rather than contextual spaces. Building on the dimensional concept of publicness, this paper investigates the impact of three publicness dimensions (ownership, political control, and goal ambiguity) on earnings management (EM) in SOEs, a managerial practice that affects the quality of financial accountability. Drawing on data from a sample of 1200 Italian SOEs, the conditional revenue model (Stubben, 2010) is used to estimate their EM during the period 2009–2017. These EM estimates are then regressed against dimensions of publicness. Findings show that publicness is either neutral or relevant for the quality of SOEs’ financial accountability, depending on the dimensions analysed: while ownership and financial control are positively related to EM in SOEs, administrative control and goal ambiguity are not statistically significant predictors of EM. Moreover, the interaction of publicness dimensions does not affect EM in SOEs. Therefore, this paper shows that SOEs’ publicness is either irrelevant or detrimental to the quality of SOEs’ financial accountability, depending on the dimension of publicness considered. Efforts should be made to define policies and governance arrangements able to influence managers’ behaviour in a way that preserves SOEs’ financial accountability.
Bioenergetics adaptations and redox homeostasis in pregnancy and related disorders
Authors: Sanchez-Aranguren Lissette , Nadeem Sarah
Published: July 2021

Pregnancy is a challenging physiological process that involves maternal adaptations to the increasing energetics demands imposed by the growing conceptus. Failure to adapt to these requirements may result in serious health complications for the mother and the baby. The mitochondria are biosynthetic and energy-producing organelles supporting the augmented energetic demands of pregnancy. Evidence suggests that placental mitochondria display a dynamic phenotype through gestation. At early stages of pregnancy placental mitochondria are mainly responsible for the generation of metabolic intermediates and reactive oxygen species (ROS), while at later stages of gestation, the placental mitochondria exhibit high rates of oxygen consumption. This review describes the metabolic fingerprint of the placental mitochondria at different stages of pregnancy and summarises key signs of mitochondrial dysfunction in pathological pregnancy conditions, including preeclampsia, gestational diabetes and intrauterine growth restriction (IUGR). So far, the effects of placental-driven metabolic changes governing the metabolic adaptations occurring in different maternal tissues in both, healthy and pathological pregnancies, remain to be uncovered. Understanding the function and molecular aspects of the adaptations occurring in placental and maternal tissue’s mitochondria will unveil potential targets for further therapeutic exploration that could address pregnancy-related disorders. Targeting mitochondrial metabolism is an emerging approach for regulating mitochondrial bioenergetics. This review will also describe the potential therapeutic use of compounds with a recognised effect on mitochondria, for the management of preeclampsia.
Diffusion tractography for awake craniotomy: accuracy and factors affecting specificity
Authors: Voets Natalie L. , Pretorius Pieter , Birch Martin D. , Apostolopoulos Vasileios , Stacey Richard , Plaha Puneet
Published: July 2021

Introduction

Despite evidence of correspondence with intraoperative stimulation, there remains limited data on MRI diffusion tractography (DT)’s sensitivity to predict morbidity after neurosurgical oncology treatment. Our aims were: (1) evaluate DT against subcortical stimulation mapping and performance changes during and after awake neurosurgery; (2) evaluate utility of early post-operative DT to predict recovery from post-surgical deficits.

Methods

We retrospectively reviewed our first 100 awake neurosurgery procedures using DT- neuronavigation. Intra-operative stimulation and performance outcomes were assessed to classify DT predictions for sensitivity and specificity calculations. Post-operative DT data, available in 51 patients, were inspected for tract damage.

Results

91 adult brain tumor patients (mean 49.2 years, 43 women) underwent 100 awake surgeries with subcortical stimulation between 2014 and 2019. Sensitivity and specificity of pre-operative DT predictions were 92.2% and 69.2%, varying among tracts. Post-operative deficits occurred after 41 procedures (39%), but were prolonged (> 3 months) in only 4 patients (4%). Post-operative DT in general confirmed surgical preservation of tracts. Post-operative DT anticipated complete recovery in a patient with supplementary motor area syndrome, and indicated infarct-related damage to corticospinal fibers associated with delayed, partial recovery in a second patient.

Conclusions

Pre-operative DT provided very accurate predictions of the spatial location of tracts in relation to a tumor. As expected, however, the presence of a tract did not inform its functional status, resulting in variable DT specificity among individual tracts. While prolonged deficits were rare, DT in the immediate post-operative period offered additional potential to monitor neurological deficits and anticipate recovery potential.
The effectiveness of antiepileptic drug treatment in glioma patients: lamotrigine versus lacosamide
Authors: van Opijnen Mark P. , van der Meer Pim B. , Dirven Linda , Fiocco Marta , Kouwenhoven Mathilde C. M. , van den Bent Martin J. , Taphoorn Martin J. B. , Koekkoek Johan A. F.
Published: July 2021

Purpose

Optimal treatment with antiepileptic drugs (AEDs) is an important part of care for brain tumor patients with epileptic seizures. Lamotrigine and lacosamide are both examples of frequently used non-enzyme inducing AEDs with limited to no drug-drug interactions, reducing the risk of unfavorable side effects. This study aimed to compare the effectiveness of lamotrigine versus lacosamide.

Methods

In this multicenter study we retrospectively analyzed data of patients with diffuse grade 2–4 glioma with epileptic seizures. All patients received either lamotrigine or lacosamide during the course of their disease after treatment failure of first-line monotherapy with levetiracetam or valproic acid. Primary outcome was the cumulative incidence of treatment failure, from initiation of lamotrigine or lacosamide, with death as competing event, for which a competing risk model was used. Secondary outcomes were uncontrolled seizures after AED initiation and level of toxicity.

Results

We included a total of 139 patients of whom 61 (44%) used lamotrigine and 78 (56%) used lacosamide. At 12 months, there was no statistically significant difference in the cumulative incidence of treatment failure for any reason between lamotrigine and lacosamide: 38% (95%CI 26–51%) versus 30% (95%CI 20–41%), respectively. The adjusted hazard ratio for treatment failure of lacosamide compared to lamotrigine was 0.84 (95%CI 0.46–1.56). The cumulative incidences of treatment failure due to uncontrolled seizures (18% versus 11%) and due to adverse events (17% versus 19%) did not differ significantly between lamotrigine and lacosamide.

Conclusion

Lamotrigine and lacosamide show similar effectiveness in diffuse glioma patients with epilepsy.
Is corruption distasteful or just another cost of doing business?
Authors: Banerjee Ritwik , Boly Amadou , Gillanders Robert
Published: July 2021

Using data from a lab experiment carried out in Kenya, we show that while “legitimate” costs and costs imposed by corruption both deter investment, the latter is no more of a disincentive than the former. We interpret the evidence as consistent with the conclusion that our participants viewed corruption as just another cost of doing business. We also experimented with giving participants in some treatments information about the corruption expectations of participants in previous sessions and the actual extent of corruption in previous sessions. We find some evidence that the objective information actually increased investment without changing the participants’ own expectations regarding corruption. That result is compatible with the idea that revealing the level of corruption changes the descriptive norm and facilitates investment in a corrupt environment.
Metabolic responses of light and taste receptors – unexpected actions of GPCRs in adipocytes
Authors: Ekechukwu Onyinye Nuella , Christian Mark
Published: July 2021

The G-protein-coupled receptor (GPCR) superfamily includes sensory receptors that can detect and respond to taste and light. Recent investigations have identified key metabolic roles for such receptors in tissues considered ‘non-sensory’ such as adipose tissue. The major functions of white and brown adipose tissues include energy storage/release and thermogenesis, respectively. These processes are tightly controlled by GPCR pathways that serve to maintain energy homeostasis. Opsins 3 and 4 are GPCRs activated by blue light and in adipocytes control lipolysis as well as affect brown adipocyte activity. Furthermore, Opsin 3 signals to regulate the conversion of white to thermogenic beige/BRITE (Brown-in-white) adipocytes. Taste receptors that respond to fatty acids, sweet and bitter are expressed in adipocytes as well as in taste buds. Ffar2 and the long chain fatty acid receptor GPR120 are highly expressed in white adipocytes and the human tongue. In adipose tissue Ffar2 mediates the metabolic effects of butyrate and propionate produced by the gut microbiome. GPR120 is highly expressed in brown adipose tissue and regulates fatty acid oxidation and mitochondrial function. The type I taste receptor Tas1r3 senses sweet and umami, is expressed in adipocytes and on obesogenic diets Tas1r3 global gene knockout protects from metabolic dysfunction. Type II taste receptors that sense bitter are expressed by adipocytes and bitter agonists have been found to modulate adipocyte differentiation and lipid storage levels. This review explores recent unexpected findings of light and taste receptors in adipocytes and examines effects of their signaling in the control of adipose tissue biology.
Credible Futures
Authors: Iacona Andrea , Iaquinto Samuele
Published: July 2021

This paper articulates in formal terms a crucial distinction concerning future contingents, the distinction between what is true about the future and what is reasonable to believe about the future. Its key idea is that the branching structures that have been used so far to model truth can be employed to define an epistemic property, credibility, which we take to be closely related to knowledge and assertibility, and which is ultimately reducible to probability. As a result, two kinds of claims about future contingents—one concerning truth, the other concerning credibility—can be smoothly handled within a single semantic framework.
Validation of MATLAB algorithm to implement a two-step parallel pyrolysis model for the prediction of maximum %char yield
Authors: Horsfall Ibiba Taiwo , Ndukwu Macmanus Chinenye , Abam Fidelis Ibiang , Olatunji Ololade Moses , Ojong Ojong Elias , Osa-Aria Keavey
Published: July 2021

Numerical modeling of biomass pyrolysis is becoming a cost and time-saving alternative for experimental investigations, also to predict the yield of the by-products of the entire process. In the present study, a two-step parallel kinetic model was used to predict char yield under isothermal condition. MATLAB ODE45 function codes were employed to solve a set of differential equations that predicts the %char at varying residence times and temperatures. The code shows how the various kinetic parameters and mass of pyrolysis products were determined. Nevertheless, the algorithm used for the prediction was validated with experimental data and results from past works. At 673.15 K, the numerical simulation using ODE45 function gives a char yield of 27.84%. From 573.15 K to 673.15 K, char yield ranges from 31.7 to 33.72% to 27.84% while experimental yield decreases from 44 to 22%. Hence, the error between algorithm prediction and experimental data from literature is − 0.26 and 0.22. Again, comparing the result of the present work with the analytical method from the literature showed a good agreement.
Rebels and Conflict Escalation
Authors: Duyvesteyn Isabelle
Published: July 2021

Violence during war often involves upswings and downturns that have, to date, been insufficiently explained. Why does violence at a particular point in time increase in intensity and why do actors in war decrease the level of violence at other points? Duyvesteyn discusses the potential explanatory variables for escalation and de-escalation in conflicts involving states and non-state actors, such as terrorists and insurgents. Using theoretical arguments and examples from modern history, this book presents the most notable causal mechanisms or shifts in the shape of propositions that could explain the rise and decline of non-state actor violence after the start and before the termination of conflict. This study critically reflects on the conceptualisation of escalation as linear, rational and wilful, and instead presents an image of rebel escalation as accidental, messy and within a very limited range of control.
Essentials of WTO Law
Authors: Van den Bossche Peter , Prévost Denise
Published: July 2021

The multilateral trading system and the WTO, its principal institution, are currently in crisis. Now more than ever, it is essential to provide a sound understanding of WTO rules and procedures, and their contribution to a secure and predictable framework for trading relations between nations. This book provides a timely and carefully considered overview of the substantive rules and institutional arrangements of the WTO, written in a concise and highly reader-friendly manner. It provides a clear and systematic discussion of key issues of WTO law, and incorporates important case law and current debates. It includes useful pedagogical features such as illustrative examples of the application of the legal framework to practical situations to facilitate understanding, as well as lists of further reading. Co-written by a leading authority in the field, it forms essential reading for anyone who wants to get to grips with this fascinating and challenging field of law.
The Expert Group’s Report on Liability for Artificial Intelligence and Other Emerging Digital Technologies: a critical assessment
Authors: BERTOLINI Andrea , EPISCOPO Francesca
Published: July 2021

This article offers a critical discussion of the “Report on Liability for Artificial Intelligence and Other Emerging Digital Technologies” released by the Expert Group on Liability and New Technologies. In particular, the authors consider: the excessive diversity of applications encompassed through the notion of “artificial intelligence and other emerging technologies”; the distinction between high- and low-risk applications as a potential source of legal uncertainty; the primary reliance on evidentiary rules over substantive ones; the problematic role attributed to safety rules; the unclear relationship between the Product Liability Directive and other ad hoc liability regimes; the radical exclusion of electronic personhood as a way of addressing liability issues; and the limited contextualisation of compulsory insurance and no-compensation funds.
Benjamin Franklin and the Reasonableness of Christianity
Authors: Slack Kevin
Published: July 2021

While much has been written on Benjamin Franklin's view of religion, less has been written on his Christian theology. This article first situates Franklin as an important figure in the religious Enlightenment, connecting his own view of philosophy to his teachings on Christian revelation. Providing historical context on the subscription debates, it then gives a comprehensive treatment of Franklin's Christian theology in the 1735 Hemphill affair. New scholarship on Franklin's transatlantic sources confirms that, far from attempting to undermine Christianity, he appealed to popular European writers in an attempt to bend it to reasonable ends. Moreover, Franklin's own views on church polity and liturgy developed over time. As he rose from a middling artisan to political power, he saw both the need for religious appeals and the threat that competing sects posed to political unity. His focus shifted from religious freedoms in private associations to institutionalizing elements of Christian teachings in education, charity, commerce, and defense. His experiences with rigid Presbyterian orthodoxy and chaotic New Light enthusiasm also awakened him to the need for more reasonable forms of worship, and he set to the task of experimenting with Christian liturgies to achieve both the tranquility of parishioners’ minds and social unity.
It’s Time to Talk to Prehospital Providers: Feedback Disparities among Ground-Based Emergency Medical Services Providers and its Impact on Job Satisfaction
Authors: McGuire Sarayna S. , Luke Anuradha , Klassen Aaron B. , Myers Lucas A. , Mullan Aidan F. , Sztajnkrycer Matthew D.
Published: July 2021

Objective:

Performance feedback on clinical care and patient outcomes is a cornerstone of medical education, yet it remains lacking in the prehospital environment. Research seeking to establish the quantity of feedback provided to Emergency Medical Services (EMS) has been limited and studies focused on complimentary feedback or how feedback relates to EMS job satisfaction are lacking. The objectives of this study were to measure the frequency and nature of feedback received by EMS agencies and to identify the importance of receiving feedback as it relates to EMS job satisfaction.

Methods:

This was an anonymous, survey-based study of twenty-nine Basic Life Support (BLS) and fifteen Advanced Life Support (ALS) agencies located in Southeastern Minnesota (USA). Descriptive statistics and Fisher exact tests were used. The study was deemed exempt by the Mayo Clinic Institutional Review Board.

Results:

Ninety-four responses were included from nineteen different EMS agencies, including sixty-one (64.9%) paramedics and thirty-three (35.1%) emergency medical technicians (EMTs). One-half of all respondents reported that they had not received any type of feedback in the past 30 days, while another 43.6% of respondents indicated that they had only received feedback one to three times in the same time period. Twenty (60.6%) EMTs reported receiving no feedback in the past 30 days, compared with twenty-seven (44.3%) paramedics (P = .123). Of respondents receiving feedback, 65.9% reported never or rarely receiving positive reinforcing feedback and 60.6% reported never or rarely receiving constructive criticism or feedback regarding something that did not go well with patient care or transport. The majority of respondents were dissatisfied with the quantity (86.1%) and quality (73.4%) of feedback received. An overwhelming majority (93.6%) indicated that feedback on patient care or outcomes was important in influencing their overall job satisfaction. This high importance was maintained across all demographic groups.

Conclusion:

Within the cohort of survey respondents, a paucity of feedback received by EMS personnel is a source of dissatisfaction for EMS providers. Feedback on patient care strongly relates to overall job satisfaction. These findings suggest system-wide opportunities for structured feedback processes, focusing upon both quality and quantity of delivered feedback, to improve both patient care and staff satisfaction.
Greece: A Procedural Defence of Democracy against the Golden Dawn
Authors: Malkopoulou Anthoula
Published: July 2021

Greece not a militant democracy – Constitution rejects party bans – Challenge posed by neo-Nazi party Golden Dawn – Preference for a procedural approach – Not as passive as previously thought – Proactive use of regular law – Golden Dawn charged for being a criminal organisation disguised as a political party – Questions about the political timing of the trial – Importance of judiciary independence – Why not a terrorist organization – Suspension of party funding and other restrictions against Golden Dawn – Actions by state institutions as opposed to local and civil society – How to distinguish between procedural- and militant-democratic initiatives – Political rights of convicted party leaders – Benefits and risks of procedural model
Improve the Performance of the Noah‐MP‐Crop Model by Jointly Assimilating Soil Moisture and Vegetation Phenology Data
Authors: Xu Tongren , Chen Fei , He Xinlei , Barlage Michael , Zhang Zhe , Liu Shaomin , He Xiangping
Published: July 2021

The interactions between crops and the atmosphere significantly impact surface energy and hydrology budgets, climate, crop yield, and agricultural management. In this study, a multipass land data assimilation scheme (MLDAS) is proposed based on the Noah‐MP‐Crop model. The ensemble Kalman filter (EnKF) method is used to jointly assimilate the leaf area index (LAI), soil moisture (SM), and solar‐induced chlorophyll fluorescence (SIF) observations to predict sensible (H) and latent (LE) heat fluxes, gross primary productivity (GPP), etc. Such joint assimilation is demonstrated to be effective in constraining the model state variables (i.e., leaf biomass and SM) and optimizing key crop‐model parameters (i.e., specific leaf area [SLA], and maximum rate of carboxylation, Vcmax). The performance of the MLDAS is evaluated against observations at two AmeriFlux cropland sites, revealing good an agreement with the observed H, LE, and GPP. When using optimized model parameters (SLA and Vcmax) and jointly assimilating LAI, SM, and SIF observations, the MLDAS produces 34.28%, 26.90%, and 51.82% lower root mean square deviations for daily H, LE, and GPP estimates compared with the Noah‐MP‐Crop open loop simulation. Our findings also indicate that the H and LE predictions are more sensitive to SM measurements, while the GPP simulations are more affected by LAI and SIF observations. The results indicate that performances of physical models can be greatly improved by assimilating multi‐source observations within MLDAS.
In Appreciation of AGU’s Outstanding Reviewers of 2020
Authors: Giampoala Matt , Frost Carol
Published: July 2021

AGU editors recognize the contributions of reviewers, whose valuable expertise continues to raise our journals’ high standards.
Frictional Melting in Hydrothermal Fluid‐Rich Faults: Field and Experimental Evidence From the Bolfín Fault Zone (Chile)
Authors: Gomila R. , Fondriest M. , Jensen E. , Spagnuolo E. , Masoch S. , Mitchell T. M. , Magnarini G. , Bistacchi A. , Mittempergher S. , Faulkner D. , Cembrano J. , Di Toro G.
Published: July 2021

Tectonic pseudotachylytes are thought to be unique to certain water‐deficient seismogenic environments and their presence is considered to be rare in the geological record. Here, we present field and experimental evidence that frictional melting can occur in hydrothermal fluid‐rich faults hosted in the continental crust. Pseudotachylytes were found in the >40 km‐long Bolfín Fault Zone of the Atacama Fault System, within two ca. 1 m‐thick (ultra)cataclastic strands hosted in a damage‐zone made of chlorite‐epidote‐rich hydrothermally altered tonalite. This alteration state indicates that hydrothermal fluids were active during the fault development. Pseudotachylytes, characterized by presenting amygdales, cut and are cut by chlorite‐, epidote‐ and calcite‐bearing veins. In turn, crosscutting relationship with the hydrothermal veins indicates pseudotachylytes were formed during this period of fluid activity. Rotary shear experiments conducted on bare surfaces of hydrothermally altered rocks at seismic slip velocities (3 m s−1) resulted in the production of vesiculated pseudotachylytes both at dry and water‐pressurized conditions, with melt lubrication as the primary mechanism for fault dynamic weakening. The presented evidence challenges the common hypothesis that pseudotachylytes are limited to fluid‐deficient environments, and gives insights into the ancient seismic activity of the system. Both field observations and experimental evidence, indicate that pseudotachylytes may easily be produced in hydrothermal environments, and could be a common co‐seismic fault product. Consequently, melt lubrication could be considered one of the most efficient seismic dynamic weakening mechanisms in crystalline basement rocks of the continental crust.
Orbital‐ and Millennial‐Scale Changes in Lake‐Levels Facilitate Earthquake‐Triggered Mass Failures in the Dead Sea Basin
Authors: Lu Yin , Moernaut Jasper , Waldmann Nicolas , Bookman Revital , Ian Alsop G. , Hubert‐Ferrari Aurélia , Strasser Michael , Agnon Amotz , Marco Shmuel
Published: July 2021

The possible link between the occurrence of submarine mass failure and climate‐driven factors is highly disputed. This is due largely to the lack of comprehensive records of mass failures in the geologic record for which ages, triggers, and preconditioning factors can be reliably constrained. Such controls would allow accurate testing of cause‐and‐effect relationships. We present a record that comprises 490 earthquake‐triggered mass failure deposits from the Dead Sea depocenter over the past 220 kyr that permits a robust statistical evaluation and correlation with potential preconditioning factors. Our data set reveals that (a) at the orbital‐ and millennial‐scale, variable sedimentation rates are not a preconditioning factor for these mass failure deposits; (b) at the centennial‐to decadal‐scale, earthquake‐triggered mass failures can occur at any lake‐level state; (c) at the orbital‐ and millennial‐scale, the mass failures are more frequent when lake‐levels were high and punctuated by large‐amplitude fluctuations.
Exhumation History Along the Muli Thrust—Implication for Crustal Thickening Mechanism in Eastern Tibet
Authors: Pitard P. , Replumaz A. , Chevalier M.‐L. , Leloup P.‐H. , Bai M. , Doin M.‐P. , Thieulot C. , Ou X. , Balvay M. , Li H.
Published: July 2021

Thrusting implication in the crustal thickening history of eastern Tibet is highly debated. The ∼250 km‐long Muli thrust of the Yalong thrust belt in SE Tibet is a major Miocene structure with a pronounced topographic step (∼2,000 m). Using thermo‐kinematic modeling based on thermochronology data, we constrain the crustal geometry of the thrust as being steep (>70°) at the surface, in agreement with field observations, and flattening at depth (≥20 km) on an intra‐crustal décollement. Thrusting motion on the fault shows a velocity of 0.2 ± 0.06 km/Ma since 50 Ma, followed by an acceleration at a rate of 0.6 ± 0.08 km/Ma starting at 12.5 ± 1 Ma, yielding a total of ∼15 km of exhumed crust. Deeper, deformation may be localized through a ductile shear zone, and be related to the ∼15 km Moho step and shear wave velocity contrast imaged by tomography beneath the Yalong thrust belt.