bluuebunny/crossref_metadata_2025 huggingface dataset:
Individualized approach to elexacaftor/tezacaftor/ivacaftor dosing in cystic fibrosis, in response to self-reported anxiety and neurocognitive adverse events: A case series
Authors: Ibrahim Hisham , Danish Hammad , Morrissey David , Deasy Kevin F. , McCarthy Mairead , Dorgan James , Fleming Claire , Howlett Ciara , Twohig Sarah , Vagg Tamara , Murphy Desmond M. , Maher Michael , Plant Barry J.
Published: April 2023

The prevalence of mental health disorders is high among people with Cystic Fibrosis. The psychological symptoms in CF are associated with poor adherence, worse treatment outcomes, and greater health utilization/cost. Mental health and neurocognitive Adverse Events (AEs) have been reported with all available Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators in small groups of patients. We report our experience with a dose reduction strategy in 10 of our patients on elexacaftor/tezacaftor/ivacaftor (7.9% of total number of patients) who self-reported developing intense anxiety, irritability, sleep disturbance and/or mental slowness after initiation of full dose treatment. Standard dose elexacaftor/tezacaftor/ivacaftor resulted in 14.3 points improvement in mean Percent Predicted Forced Expiratory Volume in 1 s (ppFEV1), and a mean difference in sweat chloride of −39.3 mmol/L. We initially discontinued and/or reduced therapy according to the AEs severity, with a subsequent planned dose escalation every 4–6 weeks guided by sustainability of clinical effectiveness, absence of AEs recurrence, and patients’ preferences. Clinical parameters including lung function and sweat chloride were monitored for up to 12 weeks to assess ongoing clinical response to the reduced dose regimen. Dose reduction resulted in resolution of self-reported mental/psychological AEs, without loss of clinical effectiveness (ppFEV1 was 80.7% on standard dose, and 83.4% at 12 weeks on reduced dose; sweat chloride was 33.4 and 34 mmol/L on standard and reduced dose, respectively). Furthermore, in a subgroup of patients who completed 24 weeks of the reduced dose regimen, repeat low dose Computed Tomography imaging showed a significant response when compared to pre-initiation of elexacaftor/tezacaftor/ivacaftor.
An analysis of teachers’ instructions and feedback at a contemporary dance university
Authors: Soerel Benjamin F. , Plaatsman Larissa A. , Kegelaers Jolan , Stubbe Janine H. , van Rijn Rogier M. , Oudejans Raôul R. D.
Published: April 2023

Background

Given the demands posed by excessive practice quantities in modern dance, physical and mental health can be compromised. Therefore, there is a need to consider how quality of practice may be improved and possibly even reduce training times. Sports literature has shown that instructions and feedback given by coaches can have an effect on the quality of training and influence self-regulation and the performance of athletes. However, currently little is known about the use of instructions and feedback by dance teachers. The aim of the current study was, therefore, to examine the type of instructions and feedback given by dance teachers during various dance classes.

Methods

A total of six dance teachers participated in this study. Video and audio recordings were made of six dance classes and two rehearsals at a contemporary dance university. The dance teacher’s coaching behavior was analyzed using the modified Coach Analysis and Intervention System (CAIS). Additionally, feedback and instructions were also examined in terms of their corresponding focus of attention. Absolute numbers, as well as times per minute (TPM) rates were calculated for each behavior before, during, and after an exercise. Absolute numbers were also used to calculate ratios of positive-negative feedback and open-closed questions.

Results

Most feedback comments were given after an exercise (472 out of 986 total observed behaviors). Improvisation had the highest positive-negative feedback ratio (29) and open-closed questions ratio (1.56). Out of the focus of attention comments, internal focus of attention comments were used most frequently (572 out of 900).

Discussion/conclusion

The results make clear that there is a large variability in instructions and feedback over teachers and classes. Overall, there is room for improvement toward a higher positive-negative feedback ratio, a higher open-closed question ratio and producing more comments eliciting an external focus of attention.
What is missing in the study of emotion expression?
Authors: Straulino Elisa , Scarpazza Cristina , Sartori Luisa
Published: April 2023

While approaching celebrations for the 150 years of “The Expression of the Emotions in Man and Animals”, scientists’ conclusions on emotion expression are still debated. Emotion expression has been traditionally anchored to prototypical and mutually exclusive facial expressions (e.g., anger, disgust, fear, happiness, sadness, and surprise). However, people express emotions in nuanced patterns and – crucially – not everything is in the face. In recent decades considerable work has critiqued this classical view, calling for a more fluid and flexible approach that considers how humans dynamically perform genuine expressions with their bodies in context. A growing body of evidence suggests that each emotional display is a complex, multi-component, motoric event. The human face is never static, but continuously acts and reacts to internal and environmental stimuli, with the coordinated action of muscles throughout the body. Moreover, two anatomically and functionally different neural pathways sub-serve voluntary and involuntary expressions. An interesting implication is that we have distinct and independent pathways for genuine and posed facial expressions, and different combinations may occur across the vertical facial axis. Investigating the time course of these facial blends, which can be controlled consciously only in part, is recently providing a useful operational test for comparing the different predictions of various models on the lateralization of emotions. This concise review will identify shortcomings and new challenges regarding the study of emotion expressions at face, body, and contextual levels, eventually resulting in a theoretical and methodological shift in the study of emotions. We contend that the most feasible solution to address the complex world of emotion expression is defining a completely new and more complete approach to emotional investigation. This approach can potentially lead us to the roots of emotional display, and to the individual mechanisms underlying their expression (i.e., individual emotional signatures).
Mental health and academic experiences among U.S. college students during the COVID-19 pandemic
Authors: Roberts Michael E. , Bell Elizabeth A. , Meyer Jillian L.
Published: April 2023

When the COVID-19 pandemic began, U.S. college students reported increased anxiety and depression. This study examines mental health among U.S college students during the subsequent 2020–2021 academic year by surveying students at the end of the fall 2020 and the spring 2021 semesters. Our data provide cross-sectional snapshots and longitudinal changes. Both surveys included the PSS, GAD-7, PHQ-8, questions about students’ academic experiences and sense of belonging in online, in-person, and hybrid classes, and additional questions regarding behaviors, living circumstances, and demographics. The spring 2021 study included a larger, stratified sample of eight demographic groups, and we added scales to examine relationships between mental health and students’ perceptions of their universities’ COVID-19 policies. Our results show higher-than-normal frequencies of mental health struggles throughout the 2020–2021 academic year, and these were substantially higher for female college students, but by spring 2021, the levels did not vary substantially by race/ethnicity, living circumstances, vaccination status, or perceptions of university COVID-19 policies. Mental health struggles inversely correlated with scales of academic and non-academic experiences, but the struggles positively correlated with time on social media. In both semesters, students reported more positive experiences with in-person classes, though all class types were rated higher in the spring semester, indicating improvements in college students’ course experiences as the pandemic continued. Furthermore, our longitudinal data indicate the persistence of mental health struggles across semesters. Overall, these studies show factors that contributed to mental health challenges among college students as the pandemic continued.
Children’s total blindness as a risk factor for early parent-child relationships: preliminary findings from an Italian sample
Authors: Gui Anna , Perelli Debora , Rizzo Giulia , Ferruzza Emilia , Mercuriali Elena
Published: April 2023

Background

Vision provides crucial information for parent-child attunement that scaffolds social development from the first months of life. Congenital blindness might affect both parental wellbeing and children’s behavior during parent-child interaction. In this study, we compared families of young children with total versus partial blindness to understand the link between residual vision, parenting stress and perceived social support, and children’s behavior during parent-child interaction.

Methods

Participants were 42 white parents (21 fathers and 21 mothers) and their congenitally blind children (14 females, mean age = 14.81 months, SD = 10.46) with no co-occurring disability, recruited at the Robert Hollman Foundation rehabilitation centers in Italy. Parents’ scores on the Parenting Stress Index and Multidimensional Scale of Perceived Social Support questionnaires, as well as children’s behaviors signaling joint engagement during video-recorded episodes of parent-child interaction, were compared between the Total Blindness (TB,n= 12 children with no light perception or light perception in the dark but no quantifiable visual acuity) and Partial Blindness (PB,n= 9 children with a residual visual acuity below 3/60) groups.

Results

We found that parents of TB children had higher parenting stress and lower perceived social support scores than parents of PB children. In fathers, total stress and stress linked to perceiving the child as difficult negatively correlated with perceived support from friends. There was no difference in the time TB and PB children spent displaying joint engagement behaviors during parent-child interaction. However, TB children directed their gaze and face less often toward their parents than PB children. We observed a trend of association between this behavior and maternal stress.

Conclusion

These preliminary results suggest that the complete absence of vision from birth has adverse effects on stress linked to parenting and parental perceived social support. These findings support the importance of early family-centered interventions that extend to the parents’ communities and facilitate the parent-child dyad’s communication through non-visual behaviors. Replication is warranted in larger and more diverse samples.
A global scale COVID-19 variants time-series analysis across 48 countries
Authors: Chu Rachel Yui Ki , Szeto Kam Chiu , Wong Irene Oi Ling , Chung Pui Hong
Published: April 2023

Background

The coronavirus disease (COVID-19) pandemic is slowing down, and countries are discussing whether preventive measures have remained effective or not. This study aimed to investigate a particular property of the trend of COVID-19 that existed and if its variants of concern were cointegrated, determining its possible transformation into an endemic.

Methods

Biweekly expected new cases by variants of COVID-19 for 48 countries from 02 May 2020 to 29 August 2022 were acquired from the GISAID database. While the case series was tested for homoscedasticity with the Breusch–Pagan test, seasonal decomposition was used to obtain a trend component of the biweekly global new case series. The percentage change of trend was then tested for zero-mean symmetry with the one-sample Wilcoxon signed rank test and zero-mean stationarity with the augmented Dickey–Fuller test to confirm a random COVID trend globally. Vector error correction models with the same seasonal adjustment were regressed to obtain a variant-cointegrated series for each country. They were tested by the augmented Dickey–Fuller test for stationarity to confirm a constant long-term stochastic intervariant interaction within the country.

Results

The trend series of seasonality-adjusted global COVID-19 new cases was found to be heteroscedastic (p = 0.002), while its rate of change was indeterministic (p = 0.052) and stationary (p = 0.024). Seasonal cointegration relationships between expected new case series by variants were found in 37 out of 48 countries (p < 0.05), reflecting a constant long-term stochastic trend in new case numbers contributed from different variants of concern within most countries.

Conclusion

Our results indicated that the new case long-term trends were random on a global scale and stable within most countries; therefore, the virus was unlikely to be eliminated but containable. Policymakers are currently in the process of adapting to the transformation of the pandemic into an endemic.
Long-term trends in the burden of edentulism in China over three decades: A Joinpoint regression and age-period-cohort analysis based on the global burden of disease study 2019
Authors: Qin Xiaofeng , He Jinan , He Haoyu , Yuan Xihua , Su Xiaohui , Zeng Xiaojuan
Published: April 2023

Background

To investigate secular trends in edentulism incidence, prevalence, and years lived with disability (YLDs) rates in Chinese men and women from 1990 to 2019.

Methods

Data were obtained from the Global Burden of Disease Study 2019. The annual percentage change and average annual percentage change were calculated using Joinpoint regression analysis. The age-period-cohort (APC) analysis estimated the independent age, period, and cohort effects.

Results

From 1990 to 2019, the crude incidence, prevalence, and YLDs of edentulism in the Chinese population increased year by year, while the age-standardized incidence, prevalence, and YLDs decreased, and the latter was higher in women than in men. The APC analysis showed that the age effect increased in men and women from age 20 to 74 and decreased thereafter. The risk of tooth loss increased with age. However, the relationship was not linear. The temporal effect showed a gradual increase; the risk of missing teeth gradually increased with the changing modern living environment. The cohort effect showed a single decreasing trend, with the early birth cohort having a higher risk of tooth loss than the later birth cohort population. The age, period, and cohort effects were consistent for both sexes.

Conclusion

Although the standardized incidence, prevalence, and YLD rate and cohort effect of dentition loss in China are declining, they are still causing a severe burden to China due to the continued aging of the population and the rising period effect. Despite the decreasing trends of the standardized incidence and prevalence of dentition loss and the rate of YLDs, China should develop more effective oral disease prevention and control strategies to reduce the increasing burden of edentulism in the older adult, especially in older women.
Female perspective: the burden of Alzheimer's disease and other dementias in China from 1990 to 2019 and prediction of their prevalence up to 2044
Authors: Meng Wenxin , Xie Jinping , Yuan Ni , Liu Pingyu , Yang Fan , Jiang Rong , Hua Hui
Published: April 2023

Background

Dementia is more prevalent in women than in men across the world, and sex differences are reflected in the burden of dementia borne by women and men. However, a few studies have specifically analyzed the disease burden of dementia in Chinese women.

Objective

This article aims to raise awareness of Chinese females with dementia (CFWD), outline an effective response to future trends in China from a female perspective, and provide a reference for the scientific formulation of dementia prevention and treatment policies in China.

Methods

In this article, epidemiological data on dementia in Chinese women were obtained from the Global Burden of Disease Study 2019, and three risk factors, namely, smoking, a high body mass index, and a high fasting plasma glucose, were selected for the analysis. This article also predicted the burden of dementia in Chinese women in the next 25 years.

Results

The prevalence of dementia, mortality, and disability-adjusted life year rates increased with age in CFWD in 2019. All three risk factors provided by the Global Burden of Disease Study 2019 showed positive correlations for the effect of disability-adjusted life years (DALYs) rates on CFWD. Among them, a high body mass index had the greatest effect (8%) and smoking had the smallest effect (6.4%). Over the next 25 years, the number of CFWD and its prevalence are expected to be on the rise, while mortality is expected to remain relatively stable and decline slightly, but deaths from dementia will continue to increase.

Conclusions

The situation arising due to the spread of dementia among Chinese women in the future is going to become a serious issue. To reduce the burden of dementia, the Chinese government should prioritize its prevention and treatment. A multi-dimensional, long-term care system involving families, community, and hospitals should also be established and supported.
The use of innovative approaches to strengthen health system resilience during the COVID-19 pandemic: case studies from selected Commonwealth countries
Authors: Mghamba Janneth , Gilmour Emily , Robinson Layne , Simba Azma , Tuyishime Albert , Persaud Anand , Mwansambo Charles , Somatunga Lakshmi , Werema Solomon , Mchwampaka Witness , Makundi Vida , Remedius Kakulu , Ronjiono Fidelis , Mutayoba Beatrice , Dushime Theophile , Rwagasore Edison , Byiringiro Baptiste , Mugumya Sylvere , Muvunyi Claude , Anthony Frank , Singh Narine , Wu Joseph Tsung-Shu , Yosefe Simeon , Dube Queen , Mayakaduwa Nimdinu , Wadugedara Rangana
Published: April 2023

This article is part of the Research Topic ‘Health Systems Recovery in the Context of COVID-19 and Protracted Conflict’.

The COVID-19 pandemic has exposed the vulnerabilities and limitations of many health systems and underscored the need for strengthening health system resilience to make and sustain progress toward Universal Health Coverage (UHC), global health security and healthier populations in tandem. In response to the COVID-19 pandemic, Commonwealth countries have been practicing a combination of innovative integrated approaches and actions to build health systems resilience. This includes utilizing digital tools, improvements in all-hazard emergency risk management, developing multisectoral partnerships, strengthening surveillance and community engagement. These interventions have been instrumental in strengthening national COVID-19 responses and can contribute to the evidence-base for increasing country investment into health systems resilience, particularly as we look toward COVID-19 recovery. This paper gives perspectives of five Commonwealth countries and their overall responses to the pandemic, highlighting practical firsthand experiences in the field. The countries included in this paper are Guyana, Malawi, Rwanda, Sri Lanka, and Tanzania. Given the diversity within the Commonwealth both in terms of geographical location and state of development, this publication can serve as a useful reference for countries as they prepare their health systems to better absorb the shocks that may emerge in future emergencies.
Transition of care from hospital to home for older people with chronic diseases: a qualitative study of older patients' and health care providers' perspectives
Authors: Sun Mengjie , Qian Yumeng , Liu Lamei , Wang Jianan , Zhuansun Mengyao , Xu Tongyao , Rosa Ronnell Dela
Published: April 2023

Background

Transitional care is a critical area of care delivery for older adults with chronic illnesses and complex health conditions. Older adults have high, ongoing care needs during the transition from hospital to home due to certain physical, psychological, social, and caregiving burdens, and in practice, patients' needs are not being met or are receiving transitional care services that are unequal and inconsistent with their actual needs, hindering their safe, healthy transition. The purpose of this study was to explore the perceptions of older adults and health care providers, including older adults, about the transition of care from hospital to home for older patients in one region of China.

Objective

To explore barriers and facilitators in the transition of care from hospital to home for older adults in China from the perspectives of older patients with chronic diseases and healthcare professionals.

Methods

This was a qualitative study based on a semi-structured approach. Participants were recruited from November 2021 to October 2022 from a tertiary and community hospital. Data were analyzed using thematic analysis.

Results

A total of 20 interviews were conducted with 10 patients and 9 medical caregivers, including two interviews with one patient. The older adult/adults patients included 4 men and 6 women with an age range of 63 to 89 years and a mean age of 74.3 ± 10.1 years. The medical caregivers included two general practitioners and seven nurses age range was 26 to 40 years with a mean age of 32.8 ± 4.6 years. Five themes were identified: (1) attitude and attributes; (2) better interpersonal relationships and communication between HCPs and patients; (3) improved Coordination of Healthcare Services Is Needed; (4) availability of resources and accessibility of services; and (5) policy and environment fit. These themes often serve as both barriers and facilitators to older adults' access to transitional care.

Conclusions

Given the fragmentation of the health care system and the complexity of care needs, patient and family-centered care should be implemented. Establish interconnected electronic information support systems; develop navigator roles; and develop competent organizational leaders and appropriate reforms to better support patient transitions.
Coping with COVID: Performance of China’s hierarchical medical system during the COVID-19 pandemic
Authors: Yang Yong , Huang Lieyu , Yan Hao , Nicholas Stephen , Maitland Elizabeth , Bai Qian , Shi Xuefeng
Published: April 2023

Objective

The COVID-19 pandemic has challenged the health system worldwide. This study aimed to assess how China’s hierarchical medical system (HMS) coped with COVID-19 in the short-and medium-term. We mainly measured the number and distribution of hospital visits and healthcare expenditure between primary and high-level hospitals during Beijing’s 2020–2021 pandemic relative to the 2017–2019 pre-COVID-19 benchmark period.

Methods

Hospital operational data were extracted from Municipal Health Statistics Information Platform. The COVID-19 period in Beijing was divided into five phases, corresponding to different characteristics, from January 2020 to October 2021. The main outcome measures in this study include the percentage change in inpatient and outpatient emergency visits, and surgeries, and changing distribution of patients between different hospital levels across Beijing’s HMS. In addition, the corresponding health expenditure in each of the 5 phases of COVID-19 was also included.

Results

In the outbreak phase of the pandemic, the total visits of Beijing hospitals declined dramatically, where outpatient visits fell 44.6%, inpatients visits fell 47.9%; emergency visits fell 35.6%, and surgery inpatients fell 44.5%. Correspondingly, health expenditures declined 30.5% for outpatients and 43.0% for inpatients. The primary hospitals absorbed a 9.51% higher proportion of outpatients than the pre-COVID-19 level in phase 1. In phase 4, the number of patients, including non-local outpatients reached pre-pandemic 2017–2019 benchmark levels. The proportion of outpatients in primary hospitals was only 1.74% above pre-COVID-19 levels in phases 4 and 5. Health expenditure for both outpatients and inpatients reached the baseline level in phase 3 and increased nearly 10% above pre-COVID-19 levels in phases 4 and 5.

Conclusion

The HMS in Beijing coped with the COVID-19 pandemic in a relatively short time, the early stage of the pandemic reflected an enhanced role for primary hospitals in the HMS, but did not permanently change patient preferences for high-level hospitals. Relative to the pre-COVID-19 benchmark, the elevated hospital expenditure in phase 4 and phase 5 pointed to hospital over-treatment or patient excess treatment demand. We suggest improving the service capacity of primary hospitals and changing the preferences of patients through health education in the post-COVID-19 world.
Keeping obesity status is a risk factor of hypertension onset: evidence from a community-based longitudinal cohort study in North China
Authors: Cai Qiujing , Zhao Xiaolei , Dong Liguang , Zhang Xinmin , Wang Chenglong , Wang Shu , Zhou Yi , Zhou Xianliang , Li Yanqi , Wang Shuyu , Liu Lisheng , Hu Aihua
Published: April 2023

Objective

The purpose of our study was to investigate the association of obesity status change with hypertension onset based on a community-based longitudinal cohort study in North China.

Methods

This longitudinal study included 3,581 individuals free of hypertension at baseline in the first survey (2011–2012). All participants were followed up (2018–2019). According to the criteria, a total of 2,618 individuals were collected for analysis. We used adjusted Cox regression models and Kaplan–Meier survival analysis to estimate the association between obesity status change and hypertension onset. Additionally, we applied the forest plot to visualize the subgroup analysis including age, gender, and the differences in some variables between baseline and follow-up. Finally, we conducted a sensitivity analysis to examine the stability of our results.

Results

Over nearly 7 years of follow-up, a total of 811 (31%) developed hypertension. The new hypertension incidence was mostly observed in those who were obese all the time (P for trend < 0.01). In the fully adjusted Cox regression model, being obese all the time increased the risk of hypertension by 30.10% [HR 4.01 (95% CI 2.20–7.32)]. The Kaplan–Meier survival analysis revealed the change in obesity status as an important feature to predict the occurrence of hypertension. Sensitivity analysis shows a consistent trend between the change in obesity status and hypertension onset in all populations. Subgroup analysis showed that age above 60 years was an important risk factor for hypertension onset, that men were more likely than women to develop hypertension, and that weight control was beneficial in avoiding future hypertension in women. There were statistically significant differences in ΔBMI, ΔSBP, ΔDBP, and ΔbaPWV between the four groups, and all variables, except baPWV changes, increased the risk of future hypertension.

Conclusion

Our study shows that obese status was notably associated with a significant risk of hypertension onset among the Chinese community-based cohort.
Post-exercise rehydration: Comparing the efficacy of three commercial oral rehydration solutions
Authors: Peden Donald L. , Funnell Mark P. , Reynolds Kirsty M. , Kenefick Robert W. , Cheuvront Samuel N. , Mears Stephen A. , James Lewis J.
Published: April 2023

Introduction

This study compared the efficacy of three commercial oral rehydration solutions (ORS) for restoring fluid and electrolyte balance, after exercise-induced dehydration.

Method

Healthy, active participants (N = 20; ♀ = 3; age ∼27 y, V˙O2peak ∼52 ml/kg/min) completed three randomised, counterbalanced trials whereby intermittent exercise in the heat (∼36°C, ∼50% humidity) induced ∼2.5% dehydration. Subsequently, participants rehydrated (125% fluid loss in four equal aliquots at 0, 1, 2, 3 h) with a glucose-based (G-ORS), sugar-free (Z-ORS) or amino acid-based sugar-free (AA-ORS) ORS of varying electrolyte composition. Urine output was measured hourly and capillary blood samples collected pre-exercise, 0, 2 and 5 h post-exercise. Sodium, potassium, and chloride concentrations in urine, sweat, and blood were determined.

Results

Net fluid balance peaked at 4 h and was greater in AA-ORS (141 ± 155 ml) and G-ORS (101 ± 195 ml) than Z-ORS (−47 ± 208 ml; P ≤ 0.010). Only AA-ORS achieved positive sodium and chloride balance post-exercise, which were greater for AA-ORS than G-ORS and Z-ORS (P ≤ 0.006), as well as for G-ORS than Z-ORS (P ≤ 0.007) from 1 to 5 h.

Conclusion

when provided in a volume equivalent to 125% of exercise-induced fluid loss, AA-ORS produced comparable/superior fluid balance and superior sodium/chloride balance responses to popular glucose-based and sugar-free ORS.
The potential of baru (Dipteryx alata Vog.) and its fractions for the alternative protein market
Authors: Egea Mariana Buranelo , de Oliveira Filho Josemar Gonçalves , Campos Stephani Borges , Lemes Ailton Cesar
Published: April 2023

The baru is a native fruit of the Brazilian Cerrado and its processing generates by-products that are normally undervalued and are not included in human food. Among the by-products of baru almond processing–the economically valued part for human consumption–are the broken almond, the partially defatted baru almond cake (DBC) and the pulp [composed of epicarp (peel) plus mesocarp]. Thus, this mini-review presents the potential use of baru (Dipteryx alataVog.) and its fractions for the alternative protein market. Baru almond and its fractions (DBC and compounds obtained by different extraction methods) stand out for their high protein content (23–30 g/100 g) and, in particular, the by-products can be used as raw material for extraction, separation, hydrolysis, isolation, and concentration of the protein molecules to produce plant-based ingredients. Although it has great potential, including sensory, nutritional, and techno-functional properties, these by-products are still few studied for this purpose.
Practitioners’ perspectives on improving ready-to-eat food vending in urban Nigeria: a practice-based visioning and back-casting approach
Authors: Adeosun Kehinde Paul , Greene Mary , Oosterveer Peter
Published: April 2023

In many parts of the world, food consumption is shifting from mostly home-based to out-of-home due to transforming of everyday lives as a result of urban development and changing infrastructure. This trend has spurred the expansion of informal ready-to-eat food vending, particularly among the urban poor. However, informal ready-to-eat food vending practices have faced challenges in provisioning menu settings with high energy and calories foods. Moreover, there are concerns about the safety, health, and diversity of food purchased through ready-to-eat food vending. This paper explores practice-oriented strategies, suggestions, and mechanisms through key actors’ experiences and perspectives to understand how the provisioning of healthy and diverse food in informal ready-to-eat food vending can be improved in urban Nigeria as a future transformative initiative. A social practice-oriented approach, combined with participatory future visioning and back-casting, was employed in a multi-phase process of interlinked focus group discussions and workshops involving key food sector stakeholders. The findings reveal that achieving an increase in diverse foods and integration of fruits and vegetables requires changing food norms and promoting sensitization to the importance of diverse diets through training initiatives involving primary actors. Additionally, key skills/competences in the provisioning of healthy and diverse foods need to be learned and relearned, while adequate food materials, finance and effective and efficient integration of the different food vending practice elements are required for the realization of these initiatives. Furthermore, understanding the relationships between food vending and other food-related provisioning practices within the food vending environment is essential in transitioning to healthier and more diverse food provisioning in the informal food vending sector. Our findings provide insights for policymakers to provide strategic pathways for practical interventions to improve food vending practices that meet the food security and nutritional needs of the urban poor.
Case report: Endoscopic closure with double stenting and autologous fascia lata graft of large tracheo-esophageal fistula
Authors: Mattioli Francesco , Serafini Edoardo , Andreani Alessandro , Cappiello Gaia , Marchioni Daniele , Pinelli Massimo , Tonelli Roberto , Clini Enrico , Marchioni Alessandro
Published: April 2023

Introduction

Radiotherapy and esophageal stenting are usually employed to manage esophageal localization of distant cancer. However, they are also related to the occurrence of an increased risk of tracheoesophageal fistula. Tracheoesophageal fistula management in these patients involves dealing with poor general conditions and short-term prognosis. This paper presents the first case in literature of bronchoscopic fistula closure through an autologous fascia lata graft placement between two stents.

Case report and aim

A 67-years-old male patient was diagnosed with pulmonary squamous cell carcinoma in the inferior lobe of the left lung with mediastinal lymph node metastasis. After a multidisciplinary discussion, bronchoscopic repair of tracheoesophageal fistula with autologous fascia lata was decided without the removal of the esophageal stent due to the high risk on the esophagus possibly related to such a procedure. Oral feeding was progressively introduced without the development of aspiration symptoms. Videofluoroscopy and esophagogastroduodenoscopy were performed at 7 months showing no signs of tracheoesophageal fistula patency.

Conclusion

This technique might represent a low risks viable option for patients unsuitable for open surgical approaches.
Effects of organic and inorganic selenium on selenium bioavailability, growth performance, antioxidant status and meat quality of a local beef cattle in China
Authors: Huang Qi , Wang Shuiping , Yang Xin , Han Xuefeng , Liu Yong , Khan Nazir Ahmad , Tan Zhiliang
Published: April 2023

Selenium (Se) is an essential nutrient with multiple health benefits to humans and animals. Cattle generally require dietary Se supplementation to meet their daily requirements. The two main forms of dietary Se in cattle are organic Se and inorganic Se. Data comparing the health and productivity effects of organic Se and inorganic Se on cattle are still insufficient, and it is necessary to conduct more research to evaluate the bioavailability, nutritional value, deposition, and body functions of Se sources in different breeds and physiological stages of cattle raised in areas with different Se levels. The objectives of this study were to determine the effects of organic and inorganic sources of Se on plasma biochemical indices, Se bioavailability, deposition in body tissues and organs, growth performance, antioxidant capacity and meat quality of beef cattle raised in Se-deficient areas. Fifteen Chinese Xiangzhong Black beef cattle with an average weight of 254.5 ± 8.85 kg were assigned to three dietary groups. The three groups were fed the same basal ration and supplemented with either an inorganic [sodium selenite (SS)] or organic [selenomethionine (SM) or Se-enriched yeast (SY)] source of Se (0.1 mg/kg dry matter) for 60 days. At the end of the experiment, three cattle from each group were randomly selected and slaughtered, and samples were collected from tissues and organs for analysis. The results revealed that growth performance, slaughter performance, Se content of tissues and organs, meat quality characteristics including chemical composition, pH45min, pH24h, drip loss, and cooking losses did not differ (p > 0.05) due to supplementation of the different organic and inorganic sources of Se. SM and SY were more effective in increasing (p < 0.05) immunoglobulin M (IgM) concentrations in the blood and reducing (p < 0.05) malondialdehyde (MDA) content in the longissimus dorsi than SS. In conclusion, organic Se is more effective than inorganic Se in improving the immune and antioxidant capacity of Chinese Xiangzhong Black beef cattle.
Mammal comparative tendon biology: advances in regulatory mechanisms through a computational modeling
Authors: Peserico Alessia , Barboni Barbara , Russo Valentina , Bernabò Nicola , El Khatib Mohammad , Prencipe Giuseppe , Cerveró-Varona Adrián , Haidar-Montes Arlette Alina , Faydaver Melisa , Citeroni Maria Rita , Berardinelli Paolo , Mauro Annunziata
Published: April 2023

There is high clinical demand for the resolution of tendinopathies, which affect mainly adult individuals and animals. Tendon damage resolution during the adult lifetime is not as effective as in earlier stages where complete restoration of tendon structure and property occurs. However, the molecular mechanisms underlying tendon regeneration remain unknown, limiting the development of targeted therapies. The research aim was to draw a comparative map of molecules that control tenogenesis and to exploit systems biology to model their signaling cascades and physiological paths. Using current literature data on molecular interactions in early tendon development, species-specific data collections were created. Then, computational analysis was used to construct Tendon NETworks in which information flow and molecular links were traced, prioritized, and enriched. Species-specific Tendon NETworks generated a data-driven computational framework based on three operative levels and a stage-dependent set of molecules and interactions (embryo–fetal or prepubertal) responsible, respectively, for signaling differentiation and morphogenesis, shaping tendon transcriptional program and downstream modeling of its fibrillogenesis toward a mature tissue. The computational network enrichment unveiled a more complex hierarchical organization of molecule interactions assigning a central role to neuro and endocrine axes which are novel and only partially explored systems for tenogenesis. Overall, this study emphasizes the value of system biology in linking the currently available disjointed molecular data, by establishing the direction and priority of signaling flows. Simultaneously, computational enrichment was critical in revealing new nodes and pathways to watch out for in promoting biomedical advances in tendon healing and developing targeted therapeutic strategies to improve current clinical interventions.
Detecting Deception Using Natural Language Processing and Machine Learning in Datasets on COVID-19 and Climate Change
Authors: Brzic Barbara , Boticki Ivica , Bagic Babac Marina
Published: April 2023

Deception in computer-mediated communication represents a threat, and there is a growing need to develop efficient methods of detecting it. Machine learning models have, through natural language processing, proven to be extremely successful at detecting lexical patterns related to deception. In this study, four selected machine learning models are trained and tested on data collected through a crowdsourcing platform on the topics of COVID-19 and climate change. The performance of the models was tested by analyzing n-grams (from unigrams to trigrams) and by using psycho-linguistic analysis. A selection of important features was carried out and further deepened with additional testing of the models on different subsets of the obtained features. This study concludes that the subjectivity of the collected data greatly affects the detection of hidden linguistic features of deception. The psycho-linguistic analysis alone and in combination with n-grams achieves better classification results than an n-gram analysis while testing the models on own data, but also while examining the possibility of generalization, especially on trigrams where the combined approach achieves a notably higher accuracy of up to 16%. The n-gram analysis proved to be a more robust method during the testing of the mutual applicability of the models while psycho-linguistic analysis remained most inflexible.
Asynchronous Gathering in a Dangerous Ring
Authors: Dobrev Stefan , Flocchini Paola , Prencipe Giuseppe , Santoro Nicola
Published: April 2023

Consider a set of k identical asynchronous mobile agents located in an anonymous ring of n nodes. The classical Gather (or Rendezvous) problem requires all agents to meet at the same node, not a priori decided, within a finite amount of time. This problem has been studied assuming that the network is safe for the agents. In this paper, we consider the presence in the ring of a stationary process located at a node that disables any incoming agent without leaving any trace. Such a dangerous node is known in the literature as a black hole, and the determination of its location has been extensively investigated. The presence of the black hole makes it deterministically unfeasible for all agents to gather. So, the research concern is to determine how many agents can gather and under what conditions. In this paper we establish a complete characterization of the conditions under which the problem can be solved. In particular, we determine the maximum number of agents that can be guaranteed to gather in the same location depending on whether k or n is unknown (at least one must be known). These results are tight: in each case, gathering with one more agent is deterministically unfeasible. All our possibility proofs are constructive: we provide mobile agent algorithms that allow the agents to gather within a predefined distance under the specified conditions. The analysis of the time costs of these algorithms show that they are optimal. Our gathering algorithm for the case of unknown k is also a solution for the black hole location problem. Interestingly, its bounded time complexity is Θ(n); this is a significant improvement over the existing O(nlogn) bounded time complexity.
A Branch-and-Price Algorithm for the Online Scheduling of Valet Drivers
Authors: Zhang Lei , Pei Zhi
Published: April 2023

In the present paper, the online valet driving problem (OVDP) is studied. In this problem, customers request a valet driving service through the platform, then the valets arrive on e-bikes at the designated pickup location and drive the vehicle to the destination. The key task is to assign the valets effectively for driving orders to minimize the overall cost. To serve that purpose, we first propose a new online scheduling strategy that divides the planning horizon into several rounds with fixed length of time, and each round consists of pooling time and scheduling time. By including the features of online scheduling and the power level of e-bikes, this OVDP becomes more practical but nevertheless challenging. To solve the OVDP, we formulate it into a set partitioning model and design a branch-and-price (B&P) algorithm. To improve the computation efficiency, a label setting algorithm is incorporated to address the pricing subproblem, which is accelerated via a heuristic pricing method. As an essential part of the algorithm design, an artificial column technique and a greedy-based constructive heuristic are implemented to obtain the initial solution. Based on the numerical analysis of various scaled instances, it is verified that the proposed B&P algorithm is not only effective in optimum seeking, but also shows a high level of efficiency in comparison with the off-the-shelf commercial solvers. Furthermore, we also explore the impact of pooling and scheduling time on the OVDP and discover a bowl-shaped trend of the objective value with respect to the two time lengths.
The Impact of Technical Training on Farmers Adopting Water-Saving Irrigation Technology: An Empirical Evidence from China
Authors: Xiuling Ding , Qian Lu , Lipeng Li , Sarkar Apurbo
Published: April 2023

Farmers’ adoption of water-saving irrigation technology (WSIT) is essential for achieving high-quality agricultural development. An in-depth analysis of the impact of risk aversion, technical training and their interaction on farmers’ adoption of WSIT will help the government to promote WSIT to facilitate agricultural resource conservation and sustainable development. The study takes 707 farmers who grow watermelons and muskmelon in Yuncheng and Xian City of Shanxi and Shaanxi provinces as the research object to analyse the influence of risk aversion and technical training and their interaction terms on farmers’ WSIT adoption behaviour. The study uses the Probit and moderating effect models to outline the findings. The empirical analysis reveals the following outcomes: (i) 27.44% of the sample farmers adopt water-saving irrigation technology, indicating that the current adoption rate and the enthusiasm for adoption are relatively low; (ii) risk aversion has a significant negative impact on farmers’ adoption of WSIT; (iii) both online and offline technical training have a significant positive impact on farmers’ adoption of WSIT; (iv) significant group differences exist in the effects of risk aversion, online technical training, offline technical training and interaction items on farmers’ WSIT adoption behaviour. Therefore, the study proposes to strengthen the role of technical training in the diffusion of WSIT and implement differentiated technical training for different types of farmers to reduce the degree of risk aversion of farmers.
Assessing the Role of Crop Rotation in Shaping Foliage Characteristics and Leaf Gas Exchange Parameters for Winter Wheat
Authors: Wanic Maria , Parzonka Mariola
Published: April 2023

Properly designed crop rotation enriches the diversity of the agroecosystem, which has a favorable effect on the environmental properties and crop yield. The experiment assessed winter wheat cultivated under the following crop rotations: A. winter rape + catch crop − spring barley − field pea − winter wheat; B. winter rape − winter wheat + catch crop − field pea − winter wheat; C. winter rape + catch crop − field pea − winter wheat − winter wheat; D. winter rape − winter wheat + catch crop − spring barley − winter wheat. The aim of the study was to investigate: (i) whether the cultivation of wheat in crop rotations following forecrops of rape, pea, barley, and wheat will affect its foliage and photosynthesis; (ii) how the photosynthetic process will affect the wheat yield. At the stem elongation stage (BBCH 36) and at the heading stage (BBCH 58), the following were investigated: foliage features, photosynthetic parameters, and the above-ground biomass; while at the BBCH 89 stage, the grain yield was investigated. It was demonstrated that photosynthesis was most intense under crop rotation A (the highest stomatal conductance, transpiration, intercellular CO2 concentration, and net assimilation rate ranged from 13.1–29.7 μmol CO2∙m−2·s−1). This was reflected in the above-ground biomass volume (1245–1634 g m−2) and grain yield (4.58–7.65 t ha−1). The cultivation of wheat following wheat under crop rotation C and following barley under D had a negative effect on both the foliage and photosynthetic parameters.