bluuebunny/crossref_metadata_2025 huggingface dataset:
Profiling the peripheral immune response to ex vivo TNF stimulation in untreated juvenile idiopathic arthritis using single cell RNA sequencing.
Authors: Imbach Kathleen J. , Treadway Nicole J. , Prahalad Vaishali , Kosters Astrid , Arafat Dalia , Duan Meixue , Gergely Talia , Ponder Lori A. , Chandrakasan Shanmuganathan , Ghosn Eliver E.B , Prahalad Sampath , Gibson Greg
Published: November 2022

Background Juvenile Idiopathic Arthritis (JIA) is an autoimmune disease with a heterogenous clinical presentation and unpredictable response to available therapies. This personalized transcriptomics study sought proof-of-concept for single-cell RNA sequencing to characterize patient-specific immune profiles.
Methods Whole blood samples from six untreated children, newly diagnosed with JIA, and two healthy controls were cultured for 24hrs with or without ex vivo TNF stimulation and subjected to scRNAseq to examine cellular populations and transcript expression in PBMCs. A novel analytical pipeline, scPool, was developed wherein cells are first pooled into pseudocells prior to expression analysis, facilitating variance partitioning of the effects of TNF stimulus, JIA disease status, and individual donor.
Results 17 robust immune cell-types were identified, the abundance of which was significantly affected by TNF stimulus, which resulted in notable elevation of memory CD8+ T-cells and NK56 cells, but down-regulation of naïve B-cell proportions. Memory CD8+ and CD4+ T-cells were also both reduced in the JIA cases relative to two controls. Significant differential expression responses to TNF stimulus were also characterized, with monocytes showing more transcriptional shifts than T-lymphocyte subsets, while the B-cell response was more limited. We also show that donor variability exceeds the small degree of possible intrinsic differentiation between JIA and control profiles. An incidental finding of interest was association of HLA-DQA2 and HLA-DRB5 expression with JIA status.
Conclusions These results support the development of personalized immune-profiling combined with ex-vivo immune stimulation for evaluation of patient-specific modes of immune cell activity in autoimmune rheumatic disease.
A Robotic System for Remote Teaching of Technical Drawing
Authors: Hiroi Yutaka , Ito Akinori
Published: November 2022

This paper describes a robotic system that supports remote teaching of technical drawing. The system aims to enable a remote class of paper-based technical drawing, where the students draw the drawing in a classroom, and the teacher gives instructions to the students from a remote place while confirming the paper drawing. The robotic system has a document camera for confirming the paper, a projector, a flat screen to project a cursor on the paper, and a video conference system for communication between the teacher and the student. We conducted two experiments; the first experiment verified that use of a projected cursor was useful for pointing the paper remotely. The second experiment was conducted in an actual drawing class, and the result showed that the students had a good impression of the system.
Hyperoside prevent Aβ42-induced neurotoxicity in PC12 cells and Caenorhabditis elegans
Authors: Wang Kexin , Zhang Xinyue , Zhang Miaosi , Li Xin , Xie Jiao , Liu Suwen , Huang Qun , Wang Jilite , Guo Qingbin , Wang hao
Published: November 2022

Traditional Chinese medicines such as hyperoside-rich Acanthopanax senticosus and Crataegus pinnatifida have been confirmed to exhibit anti-oxidative stress properties. Hyperoside, the main ingredient of numerous antioxidant herbs, may have the ability to postpone the onset of neurodegenerative diseases This study investigates the possible therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer’s disease (AD) in Caenorhabditis elegans and PC12 cells. Specifically, hyperoside reduced reactive oxygen species (ROS) level and Aβ42-induced neurotoxicity in C. elegans worms. Meanwhile, hyperoside reduced ROS production and increased mitochondrial membrane potentialin Aβ42-induced PC12 cells, which possibly due to the increase of antioxidant enzymes activity and the diminution of malondialdehyde levels. Hoechst 33342 staining and real-time PCR results suggested that hyperoside reverses cell apoptosis. Network pharmacology predicts potentially relevant hypericin targets and pathways in AD therapy. As anticipated, hyperoside reversed Aβ42-stimulated downregulation of the PI3K/Akt/Nrf2/HO-1. The PI3K inhibitor LY294002 partially abolished the protective capability of hyperoside. The results of molecular docking further indicated that the PI3K/Akt pathways may be involved in the protection of Aβ42-induced PC12 cells by hyperoside treatment. The study provides theoretical information for research and development of hyperoside as an antioxidant dietary supplement.
Vasopressin as adjunctive therapy in pulmonary hypertension associated with refractory systemic hypotension in term newborns
Authors: Santelices Felipe , Masoli Daniela , Kattan Javier , Toso Alberto , Luco Matias
Published: November 2022

Objective. The aim of our study is to describe the effects of vasopressin on term infants with persistent pulmonary hypertension under a standardized protocol.
Study Design: In 2019, we designed a standardized protocol for the management of refractory hypotension in the context of pulmonary hypertension, which included the use of vasopressin. This is a retrospective cohort study to evaluate the clinical, laboratory, and echocardiographic outcomes of patients who required vasopressin in the context of this new protocol in a referral level IV neonatal intensive care unit.
Results: We included 48 neonates with a median gestational age of 37 weeks in a period of 30 months (December 2019 to May 2022). Congenital diaphragmatic hernia was the main cause of persistent pulmonary hypertension in this cohort (82%). All patients were on mechanical ventilation and receiving inhaled nitric oxide.
In our cohort at 4 hours after initiation of vasopressin, blood pressure, serum pH, and urinary output increased significantly. The vasoactive inotropic score, lactate and oxygenation index decreased. Echocardiographic follow-up also showed a decrease in the relative pressure of the right ventricle and an improvement in the cardiac output of both ventricles. There were no episodes of severe hyponatremia (<120 mmol/L).
Discussion: This study showed that the use of vasopressin in neonates with persistent pulmonary hypertension and refractory systemic hypotension was associated with a rapid and significant improvement in oxygenation and hemodynamic markers of perfusion, including blood pressure. This association was early during the first hours of treatment and vasopressin was safely withdrawn after a median of 3 days of treatment.
Well posedness and exponential stability of a thermoelastic Shear beam model
Authors: Benmoussa Asma , Fareh Abdelfeteh , Messaoudi Salim A. , Alahyane Mohamed
Published: November 2022

In this work we investigate a thermoelastic shear beammodel with thermal dissipation. We prove a well posedness result by the use of the Faedo--Galerkin method and the exponential stability by the multiplier method. cOur result improves the stability results obtained for certain thermoelasticTimoshenko type systems in the sense that we do not require any relationshipbetween the wave speeds since our system has only one wave speed. We also give by the end some numerical experiments to illustrate our theoretical results.
Effect of Preprocessing and Loss Functions on a Novel Dataset: An Application on MRI-Based Prostate Lesion Segmentation using U-Net
Authors: Gurkan Caglar , Budak Abdulkadir , Karatas Hakan , Akin Kayihan
Published: November 2022

Prostate cancer is one of the riskiest types of cancer, while it is the second most common type of cancer in men and it is likely to result in death. While the diagnosis of prostate cancer is vital, it is complex, time-consuming, and the technologies used in its diagnosis are limited. The need for high technology for the diagnosis of prostate cancer is increasing day by day. One of the technologies used in health nowadays is artificial intelligence. Therefore, artificial intelligence-supported decision support systems should be used in the diagnosis of prostate cancer. However, the number of studies using artificial intelligence for the diagnosis of prostate cancer is limited. One of the most important reasons for this is the fewness of open-source data sets. Therefore, in this study, a novel MRI data set was created by an expert radiologist. The U-Net model was trained and tested using this data set. Different preprocessing methods and loss functions were studied for the training of the model. The used preprocessing techniques are (i) min-max normalization technique, (ii) z-score normalization technique, (iii) min-max normalization technique on 256 by 256 pixels cropped images, (iv) z-score normalization technique on 256 by 256 pixels cropped images, and (v) patch-wise analysis on 256 by 256 pixels cropped images. The used loss functions are Cross-Entropy, Dice, IoU, Tversky, Focal Tversky loss functions, and compound loss functions of these. Considering the combination of preprocessing techniques and loss functions, the compound loss function of Cross-Entropy and Dice loss functions have outperformed the patch-wise analysis on 256 by 256 pixels cropped images. In this pipeline, the U-Net model achieved a 0.917 dice score, 0.846 IoU score, 0.890 sensitivity, 0.998 specificity, 0.945 precision, and 0.995 accuracy. Consequently, a decision support system was developed for the diagnosis of prostate cancer.
The impact of acetazolamide - the ionic surfactant on the double layer parameters at the R-AgLAFe/ chlorates(VII) interface
Authors: Martyna Marlena , Pawlak Alicja , Bazan-Woźniak Aleksandra , Nosal-Wiercińska Agnieszka , Pietrzak Robert
Published: November 2022

Adsorption of acetazolamide (ACT) and the mixed adsorption layers of acetazolamide (ACT) - sodium 1-decanesulfonate (SDS) and acetazolamide - hexadecyltrimethylammonium bromide (CTAB) formed at the R-AgLAFe/ chlorates(VII) interface is described. The systems were characterized by the measurements of differential capacity, potential of zero charge, and surface tension at this potential. The adsorption parameters determined in the studied systems indicate the SDS domination in the adsorption equilibria formation and the competitive adsorption between the ACT - SDS or mixed micelles. However, acetazolamide dominates in the formation of adsorption equilibria of the ACT - CTAB mixture.
Determining the Clinical Value of Routine Post-operative follow-up in Common Paediatric Surgical Conditions: Prospective Observational Study
Authors: Menon Revathy , Pathak Manish , Nayak Shubhalaxmi , Gupta Manoj Kumar , Saxena Rahul , Jadhav Avinash , Rathod Kirtikumar , Sinha Arvind
Published: November 2022

BACKGROUND:
The traditional postoperative visit consists of an in-person hospital visit at a predetermined date requiring investment of time and resources. This study aims to determine , clinical value of routine post-operative physical follow-up for common paediatric surgery conditions, identifying factors determining the need and estimating the cost of follow-up.
METHODOLOGY:
Data of 226 patients admitted for routine paediatric surgical procedures were collected.
The postoperative period was documented in detail and interventions done either physically or telephonically at follow-up were used as a proxy measure of clinical value.
RESULTS:
Out of 226 patients, 64.6% followed up physically and 35.4%, telephonically. Maximum patients with post-operative complications belonged to laparotomy group (22.2%) followed by complicated appendicitis (15.6%). Thirty (13.3%) patients required clinical intervention at follow-up. Patients with requirements of clinical intervention were observed to follow-up earlier than routine follow-up date, either by telemedicine or physical follow-up.
CONCLUSION:
Patients undergoing simpler procedures have lesser complications translating to fewer clinic visits whereas those undergoing procedures such as appendectomy and laparotomy require a physical follow-up since they are more susceptible to develop complications requiring interventions. By selecting patients for physical visit we can potentially eliminate unnecessary postoperative visits.
Type of study: Prospective Observational Study
Level of evidence: Level III
Study on the relationship between heat island effect, PM 2.5 and urbanization in the Beijing-Tianjin-Tangshan region
Authors: Shao Jingjing , Ge Jingfeng
Published: November 2022

With the rapid progress of urbanization in Beijing-Tianjin-Tangshan region, heat island effect and air pollution have become common environmental problems in the study area. How to coordinate the relationship between urbanization and ecological environment is extremely urgent. Therefore, based on geographical weighted regression model, Tapio decoupling theory and environmental Kuznets curve, this paper systematically analyzes the relationship between heat island effect, PM2.5 and urbanization in Beijing-Tianjin-Tangshan region. The results show that: 1) The intensity of heat island is mainly increasing in urban built-up areas, and has a certain relationship with economic development, which is shown as "Beijing > Tianjin > Tangshan > Langfang". In addition, the increase of heat island intensity slows down in the later stage of the study. 2) The concentration of PM2.5 increased from 2001 to 2013, the air quality improved significantly after 2013. And PM2.5 has obvious seasonal and daily variation characteristics. Furthermore, PM2.5 concentration has significant spatial agglomeration and diffusion. The average interaction distance between cities in Beijing-Tianjin-Tangshan region is 190km. 3) In the whole study period, the urbanization process in the study area has been moving forward despite fluctuations. There are obvious differences in urbanization among the cities in the urban agglomeration. The urbanization of Beijing and Tianjin is developing rapidly, and the spatial expansion is in the form of concentric circles or along the extension axis. 4) Geographical weighted regression model finds that urbanization has a high impact on heat island effect and PM2.5, and both are positively correlated. The decoupling theory indicates that the relationship between urbanization and heat island effect in the study area is dominated by expansion negative decoupling and weak decoupling, while the relationship between urbanization and PM2.5 is mainly weak decoupling and strong decoupling. The environmental Kuznets curve draws the conclusion that the relationship between heat island effect, PM2.5 and urbanization in the study area presents an "N-shaped" respectively. In general, the relationship between heat island effect, PM2.5 and urbanization of Beijing-Tianjin-Tangshan region had become more and more harmonious from 2001 to 2017.
Prevalence of undernutrition and associated factors among children, aged 6-59 months from WASH project and non-WASH project implementing Kebeles of Tach Gayint Woreda North West, Ethiopia, 2019
Authors: Shimelash Alebachew , Tilaye Wondimnew , Eshetie Sisaye , Tegegne Eniyew
Published: November 2022

Background
Nutritional scantiness is a leading cause of wasting, stunting, and being underweight in children all over the world. Stunting induces developmental delays, decreased cognitive function, an increased risk of chronic disease, and a decrease in the national economy. This study deliberate to assess the prevalence and associated factors of undernutrition WASH project and non-WASH project implementation Kebeles among children aged 6 to 59 months in Tach Gayint district, North West Ethiopia.
Methods
A community-based comparative cross-sectional study was conducted amongst 1120 children aged 6–59 months randomly selected in Tach Gayint District from January 2019 to February 2019. The sample size was calculated using the double proportion formula. Data were entered into Epi Info version 7 and exported to SPSS version 20 for analysis. The association between dependents and independent variables was tested using multivariable logistic regression. The statistical association was declared with 95% confidence intervals at a p-value of less than 0.05.
Result
The prevalence of stunting, underweight, and wasting was 49.4%, 17.0%, and 12.8% respectively. Diarrheal (AOR = 8.01; 95% CI: 1.62–39.45), Sex (AOR = 1.80, 95% CI: 1.26–2.58) and unimproved water source (AOR = 1.918, 95% CI: 1.389–2.64) were independent factors.
Conclusion
Undernutrition was a major public health issue among children aged 6 to 59 months according to WHOs cut of points. Unimproved water sources, the sex of the child, and frequent diarrheal infection were associated factors for undernutrition. Therefore, strengthening the implementation of WASH activities to increase the coverage of improved water supply and prevention and control of diarrheal infection should be included in the prevention strategies of undernutrition.
Diagnostic utility of flow cytometry in resource-constrained settings- a single center experience
Authors: Khattak Awal Mir , Mushtaq Hina , Yousafzai Yasar Mehmood , Hameed Mehreen , Khan Sadiq Noor , Islam Mujahid
Published: November 2022

Background: Flow cytometry (FC) is an expensive investigation that is unaffordable for many patients from underprivileged nations. We aimed to reduce the total budget of the test by optimizing a limited antibody panel as guided by morphological assessment.
Materials and methods: This single-center, the experimental study included 247 patients referred for Flow cytometry at Rehman Medical Institute, Peshawar.There were 162 male (65.4 %) and 85 female patients (34.6%) with a mean age of 38.78±21.55 years. Bone marrow or peripheral blood samples were used for immunophenotyping. After the morphological assessment, a limited panel of flow markers was selected. All samples were stained with fluorochromes labeled monoclonal antibodies, acquired, and analyzed with a flow cytometer (Cytoflex, BeckMan-Coulter, USA). Data were statistically analyzed through SPSS-22, and descriptive statistics were applied for all variables. All results were presented in form of graphs, tables, and charts
Results: Out of 247 cases, an Acute leukemia panel was requested for 128 cases, a lymphoproliferative panel for 56 cases, T-cell subset analysis for 53 cases, and PNH clone screening for 10 cases. Newly diagnosed cases were 221 while 26 cases were known labeled cases of Acute leukemia for Minimal Residual Disease (MRD) analysis. Among the cases for MRD analysis, 10 cases were in remission, 12 cases relapsed and 04 cases were not in the remission phase.
98% of cases referred for Acute leukemia and Lymphoproliferative disorders, and 100% of cases referred for proximal nocturnal Hemoglobinuria (PNH) and T-cell subset analysis was conclusively diagnosed by our limited flow cytometry panels with low-cost effect.
Conclusions: In resource-constrained settings, optimization of a limited antibody panel is extremely facilitating to provide a Flow cytometry-based diagnosis which further guides the treatment decision.
Characterization of splenic and systemic immunity by differentially charged lipid adjuvants in enhancing post-intranasal immunization response against influenza
Authors: Sengupta Anirban , Al-Otaibi Noha , Devito Claudia , Lottersberger Francisca , Hinkula Jorma
Published: November 2022

Background: At this time when vaccine development is at its peak against different respiratory diseases, it is of utmost importance to find suitable adjuvants that can increase the potency of the vaccine candidates. This study aims to find the systemic and splenic immune mechanism exhibited in mice models by anionic and cationic lipid adjuvants in presence of vaccine-candidate influenza antigen Hemagglutinin (HA).
Results: The study demonstrates how anionic and cationic lipid adjuvants can differ in their mechanism to induce immune protection. In presence of HA antigen, the cationic adjuvant (N3) induces enhanced dendritic cell activity, MHCI, CD80-CD86 costimulatory marker expression with significantly higher CD8T and Th17 population with enhanced interferon-gamma (IFNγ) expression in CD8T and CD4T populations. Anionic adjuvant (L3) induces significantly higher MHCII and DEC205 expression on dendritic cells with significantly increased CD4T and regulatory T cell population. This L3 treatment group also exhibited a higher plasma B cell population with significantly higher antigen-specific IgG and IgA titer with virus neutralization potential.
Conclusion: Thus, in this study, we illustrate how the use of differentially charged lipid adjuvants in combination with influenza HA antigen, drives differential adaptive immune response patterns. While anionic adjuvants are significantly higher humoral responses than cationic adjuvants, the latter influence significantly higher Th1/Th17 response. It is much more difficult to find a suitable and safer candidate vaccine antigen than to simply alter the associated adjuvant for a customized vaccination program. This will pave the way forward in the selection of the adjuvants based on their charges in boosting specific immune response arms in the future development of vaccine formulation.
Protective effect of poly(ADP-ribose)polymerase inhibition on light-induced ciliary degeneration in photoreceptors
Authors: Che Lin , bao xiaoli , Fan Bin , Cong Yun-yi , Li Guang-Yu
Published: November 2022

Prolonged light exposure may induce retinal damage and degeneration of cilia and photoreceptor cells. This study investigated the protective effect of poly (ADP-ribose) polymerase (PARP) inhibition on light-induced retinal damage in vitro and in vivo. A murine cone photoreceptor 661W cell line and an animal model of light-induced retinal damage in C57BL mice were used to assess light-induced cell damages and death as well as to elucidate the underlying molecular events. The data showed that light exposure induced 661W cell death by reducing the proportion of cells with cilia and destroying the structure of the outer segments (OS) of photoreceptors. PARP expression knockdown or use of a PARP inhibitor was able to protect cells against light-induced damage in vitro and in vivo. While exposure to light induced photoreceptor degeneration and cell death, PARP expression knockdown and treatment with a selective PARP inhibitor as well as an Akt activator protected retina cells by improving cell survival and maintaining the structure of the OS of photoreceptor cells (including cilia on the cell membrane) during the process of light-induced damage. This study demonstrated that activation of the PI3K/Akt pathway facilitates the protective effect of PARP inhibition on retinal cells damaged by exposure to the light.
Interpersonal relationship and the risk of major depressive disorder: findings from a 1-year Chinese freshmen follow-up study
Authors: Sun Haiya , Qian Yandan , Sun Junsheng , Mu Fuqin , Jiang Fengxia , Xu Ruixue , Liu Yujia , Sun Hao , Liu Yanzhi , Zhu Jin , Wang JianLi , Liu Yan
Published: November 2022

Purpose: The aim of this study was to investigate the association between interpersonal relationships and the risk of MDD in freshmen.
Methods: 6,947 participants without baseline MDD (lifetime) completed the 1-year follow-up survey in 2019. Demographic information, interpersonal relationship scores measured by the Chinese version of Interpersonal Relationship Comprehensive Scale, depression severity at baseline screened with Patient Health Questionnaire-9, lifetime severe traumatic events and MDD at baseline and follow-up survey screened via the Composite International Diagnostic Interview 3.0 were collected. Logistic regression was performed to quantify the associations between interpersonal relationships and the new-onset of MDD.
Results: The baseline total relationship score (9 to 14, mild relationship distress) and the dimension score of dealing with people were positively associated with MDD incidence, respectively (OR total score=1.68, 95%CI: 1.16-2.43; OR dealing with people=1.39, 95%CI: 1.10-1.75). Interpersonal relationship score was not associated with MDD in participants without baseline depressive symptoms. However, it was positively associated with MDD (OR=2.10, 95%CI: 1.40-3.15) among participants with baseline depressive symptoms. There was a statistically significant interactions between dealing with people and baseline PHQ-9 score for the risk of MDD.
Conclusions: Interpersonal relationship perplex can increase the risk of MDD in college students. College students suffering from depressive symptoms without MDD yet who have interpersonal disorder deserve more attention in terms of prevention against MDD.
Time-related circumstances define youths' self-management following the unexpected loss of a family member to HIV/AIDS
Authors: Hlophe Siphesihle Delani , Jooste Karien
Published: November 2022

Background: There is a high incidence of depression in youth who are stressed, making them less likely to engage in active self-management strategies such as exercise due to the trauma of losing a family member. Youths visit public hospitals for various reasons, including panic attacks and anxiety, which are often experienced after the passing of a family member. The aim was to explore the lived experiences of youths on managing themselves after losing a family member to HIV/AIDS and develop guidelines for nurses to advise youths on self-management following the loss of a family member to HIV/AIDS.
Methods: A descriptive phenomenological design was followed for a study at a Comprehensive Healthcare Clinic in the Western Cape Province of South Africa. The sample was selected through purposive sampling until data saturation was achieved. Individual semi-structured interviews with 11 participants were conducted, after which data saturation was established.
Results: Accordingly, based on the findings, the research developed guidelines that nurses can use to advise youths on self-managing themselves after the unexpected loss of a family member to HIV/AIDS.
Conclusion: The youths need to practice self-management during unexpected situations to cope with the death of family members with HIV/AIDS. Nurses at the Comprehensive Healthcare Clinic can use the developed guidelines to assist youth on self-management.
A bibliometric analysis of the scientific production of clay-based polymeric nanocomposites.
Authors: Costa Robson Soares , Menezaes Mario O. , Moura Esperidiana A. B.
Published: November 2022

Clays and clay minerals are widely used in many facets of our society. Therefore, when dealing with the formation of polymer/clay nanocomposites, it promotes significant changes in mechanical, physical, and chemical properties in relation to the pure polymer matrix. This increases the interest of researchers in the field of nanotechnology, especially when it comes to the following properties: increase in strength and rigidity, improvement of rheological properties, and, mainly, increasing barrier properties to gasses and liquids. The objective of this work is to carry out a review of the literature on the academic production of clay-based polymeric nanocomposites and their applications in research areas in institutions around the world, using mapping analysis using the VOSviewer Software. A reference manager application was used to retrieve survey data. The data obtained are the result of a search for the keyword “clay and polymers and nanocomposites”. Up to 14,786 articles published related to the themes were analyzed between 1991 and 2022. Results showed that research on the production of clay-based polymeric nanocomposites increased from 1995 to 2014, but decreased from 2015 to 2021. his study helps researchers to conduct and determine targeted research topics and serve as a reference.
Hydropluviometric variability in a forest watershed undergoing accelerated urbanization: the case of Mefou (South Cameroon)
Authors: Ebode Valentin Brice
Published: November 2022

This article has as objective to investigate the impact of rainfall variability and land use changes on river discharge in the Mefou basin over the recent period (1963–2018). To achieve this goal, hydrometeorological data of this basin were analyzed using the Pettitt test. Likewise, land use changes were also analyzed using supervised classifications of Landsat satellite images at two periods (1973 and 2018). Average and extreme flows of Mefou river have increased since 1985-86, unlike the rainfall, which generally decreased for all seasons from the 1970s, apart from summer, where the reverse was observed. Changes in land use (increase impervious areas and a decrease in forest and water bodies) seem to be the main cause of the increase in runoff observed. The rainfall plays an essentially amplifying role in the increase in discharge in the seasons during which they occur. Those having experienced an increase or a maintenance of rainfall (summer and spring) recorded the most significant increases in discharges. These results could be useful for the improvement of future simulations of the Mefou river flow and the prevention of socio-environmental disasters like floods in the basin.
A study of cardiovascular complications after general surgeries in Damascus Hospital in Syria
Authors: Chebat Mohamad , Shamieh Prof. Marwan , Aoudeh Mohamad
Published: November 2022

Background
Despite the advantages of surgery, it can trigger cardiac events; including heart attacks, heart failure, heart rhythm disturbances, and death. Previous research has shown that out of patients who were never admitted to critical care, nearly three-quarters died after surgery suggesting that their risk was unrecognized.
Methods
Data from 200 surgical patients registered at the general Surgery department in Damascus hospital who were examined and observed within 72 hours after their general surgery from March 2022 to June 2022.
Study design
A cross-sectional study conducted in Syria
Results
- 4.5% of patients undergoing general surgery have developed postoperative cardiovascular compilations.
- Cardiovascular complications were developed in 37.5% of the patients who underwent colon tumor resection., in 20% of patients who underwent a partial mastectomy, in 4.9% of Cholecystectomy patients, and in 1.2% of Appendectomy patients.
Conclusion
This study shows a high percentage of cardiovascular complications (4.5%) after 72 hours of general surgeries.
Ecological analysis of Demographic, Nutritional and Housing related factors associated with anaemia among women of reproductive age group in Nigeria.
Authors: Kareem Yusuf Olushola , Ameyaw Edward K. , Bello Oluwasomidoyin O. , Abdus-Salam Rukiyat A. , Lawal Olatunji O. , Obajimi Gbolahan , Kofoworola Alade Yussuf , Morhason-Bello Imran O.
Published: November 2022

Introduction
Anaemia remains a major public health concern, particularly, in sub-Saharan Africa (SSA), where it is one of the causes of maternal death. The most common cause of maternal anaemia is iron deficiency or malnutrition. This study examined the prevalence of, and risk factors for anaemia among women that participated in the Nigerian Demographic Health Survey.
Method
The data from 14,454 women that participated in the 2018 Nigeria Demographic and Health Survey (NDHS) were utilized for this study and we extracted information such as demographic, social and housing, dietary characteristics and haemoglobin concentration. The descriptive statistic results, prevalence and 95% Confidence Interval (CIs) of anaemia with the selected respondents’ background characteristics were presented. The Poisson regression model with robust variance was used to assess the risk of anaemia among women of reproductive age. All analyses were weighted and adjusted for the complex survey design. Statistical significance was interpreted at p-value < 0.05.
Results
Maternal status, body mass index, education, residence, religion, ethnicity, region and type of cooking fuel were all important determinants of anaemia. The prevalence of anaemia was high among pregnant women (61.8%; 95% CI: 58.5–65.0), adolescents (60.4%; 95% CI: 58.1–62.6), underweight women (62.6%; 95% CI: 59.5–65.5), women who had no formal education (64.1%; 95% CI: 62.2–66.0) and those who belonged to the poorest wealth quintile (65.8%; 95% CI: 63.1–68.4). Similarly, anaemia was high among women residing in rural areas (61.5%; 95% CI: 60.0–63.0), Muslims (59.9%; 95% CI: 58.1–61.6) and women with six or more children (62.1%; 95% CI: 60.0-64.1). The risk of anaemia was 2% less likely among women who took a minimum adequate diet compared to those who do not.
Conclusion
To date, this is the largest data on maternal anaemia in Nigeria. The study highlighted the high burden of maternal anaemia in the country and different risk factors (medical and social) that are associated with this medical condition among women of reproductive age. We recommend future longitudinal studies to test this hypothesis in order to assess whether there is any causal relationship between identified risk factors and anaemia in this group of women.
Machine learning models with time-series clinical features to predict radiographic progression in patients with ankylosing spondylitis
Authors: Koo Bon San , Jang Miso , Oh Ji Seon , Shin Keewon , Lee Seunghun , Joo Kyung Bin , Kim Namkug , Kim Tae-Hwan
Published: November 2022

Background
Ankylosing spondylitis is chronic inflammatory arthritis that causes structural damage to the spine due to repeated and continuous inflammation over a long period of time. The purpose of this study was to establish the application of machine learning models for predicting radiographic progression in patients with AS using time-series data from electronic medical records (EMRs).
Methods
EMR data, including baseline characteristics, laboratory finding, drug administration, and modified Stoke Ankylosing Spondylitis Spine Score (mSASSS), were collected from 1,123 AS patients who were followed up for 18 years at a common center at the time of first (T1), second (T2), and third (T3) visits. The radiographic progression of the (n + 1)th visit (Pn+1 = (mSASSSn+1 – mSASSSn) / (Tn+1 – Tn) ≥ 1 unit per year) was predicted using follow-up visit datasets from T1 to Tn. Three machine learning methods (logistic regression with least absolute shrinkage and selection operation, random forest, and extreme gradient boosting algorithms) with three-fold cross-validation were used.
Results
The random forest model using the T1 EMR dataset showed the highest performance in predicting the radioactive progression P2 among all the machine learning models tested. The mean accuracy and the area under the curves were 73.73% and 0.79, respectively. Among the variables of T1, the most important variables for predicting radiographic progression were in the order of total mSASSS, age, and alkaline phosphatase.
Conclusion
Prognosis predictive models using time-series data showed reasonable performance with clinical features of the first visit dataset for predicting radiographic progression. Additional feature data such as spine radiographs or life-log data may improve the performance of these models.
ЭМПЕДОКЛ В ДИАЛОГАХ ПЛАТОНАСВИДЕТЕЛЬСТВА И ПРЕЕМСТВЕННОСТЬ ИДЕЙ
Authors: А.С. Афонасина
Published: November 2022

После выхода в свет монументальной работы Тэйлора «Комментарий на ‘Тимей’ Платона» (Taylor [1928]), мысль о том, что Эмпедокл оказал большое влияние на формирование некоторых идей о строении космоса, стала популярной во многих исследованиях последующих лет. Серьезный отпор эта мысль получила в статье Хершбелла «Влияние Эмпедокла на ‘Тимей’» (Hershbell [1974]), где автор последовательно разбирает все попытки связать Эмпедокла с Платоном, отбрасывает их как неубедительные и соглашается признать влияние со стороны Эмпедокла только в области физиологии, а именно на учение Платона об устройстве человеческого тела (ногтях и волосах). Основной аргумент Хершбелла состоит в том, что нигде в «Тимее» мы не находим прямого заимствования Эмпедокловых терминов, тогда как очевидная созвучность идей слишком поверхностна и может быть общим местом (Hershbell [1974], p. 151). Попытка устроиться где-то между восторженным Тэйлором и критичным Хершбеллом меня не устраивает. Поэтому в этой статье я предпринимаю попытку рассмотреть вопрос о связи Эмпедокла с Платоном несколько иначе. В первую очередь, я намерена проанализировать все упоминания об Эмпедокле и его учении в разных диалогах, и, во-вторых, обратить внимание на некоторые, имеющие явный технический подтекст, слова, которые встречаются и у Эмпедокла, и у Платона.

The article deals with a controversial question about possible Empedoclean influence on Plato’s Timaeus. I consider two opposite views on this problem: the position of Taylor and the critical attitude of Hershbell. First, I consider all references on Empedocles and his teaching in Plato’s dialogs; secondly, I give attention to several words that have clear technical background, which we can find both in Empedocles and in Plato. Finally, I intend to show that Empedocles affected some aspects of Plato’s physiology and cosmology, the most interesting parallel being a similarity of the images of Platonic Demiurge and Empedoclean Aphrodite.
ДЕРИВАЦИОННЫЕ СЛОВАРИ ИЛАТИНСКАЯ УЧЕНОСТЬВ ИТАЛИИ XI–XIII ВЕКОВ
Authors: А.В. Кульпина
Published: November 2022

В статье рассматривается ученая активность латинских школ Италии XI–XIII вв., результатом которой стало появление специфической разновидности лексикографических сочинений — деривационного словаря. Рассматриваются герменевтические процедуры и практики таких лексикографов и энциклопедистов как Исидор Севильский, Папий Ломбарский, Угуччоне Пизанский, Иоанн Генуэзский. Обсуждаются их античные латинские и греческие источники, способы и методы организации знания в составленных ими деривационных словарях. Исследуются особенности деривационной объяснительной модели (per derivationem), начиная с Исидора Севильского. Обращено внимание на неразрывность лингвистического, семантического и онтологического пластов реальностей, характерную для миросозерцания рассматриваемых авторов, смешивавших оперирование лексемами и денотатами — объектами внеязыковой реальности.

The article treats the scholarly activity of the Latin schools of Italy in the 11th-13th centuries, which produced a specific type of lexicographic works, a derivational dictionary. The hermeneutic procedures and practices of such lexicographers and encyclopedists as Isidore of Seville, Papias the Lombard, Huguccio of Pisa, John of Genoa are considered. Their ancient Latin and Greek sources, means and methods of organizing knowledge in the derivational dictionaries compiled by them are discussed. The peculiarities of the derivational explanatory model (per derivationem), starting with Isidore of Seville, are investigated. Attention is paid to the inseparability of linguistic, semantic and ontological layers of realities, characteristic for the worldview of the authors under discussion, whose operation did not distinguished lexemes and their denotata, objects of extralinguistic reality.
«Я НАЧИНАЮ КАЙ — СЛУШАЙ, ПАЛАМ»ЧУДЕСНЫЙ ДАР В ЭПИЧЕСКОЙ ТРАДИЦИИТЮРКОВ ЮЖНОЙ СИБИРИ
Authors: М.В. Егорочкин
Published: November 2022

В статье рассматриваются представления тюрков Южной Сибири о сказительском даре и исполнении эпоса. Основной акцент при этом делается не столько на «внешних», фактических описаниях мастерства сказителей, сколько на его «внутренних», фольклорных истолкованиях. Разработанный отечественными фольклористами (прежде всего Е.М. Мелетинским, С.Ю. Неклюдовым и Е.С. Новик), такой подход позволяет по-новому взглянуть на тексты, повествующие о получении, передаче и возвращении сказительского дара. В результате последовательного анализа этих текстов выявляется единый механизм эпической коммуникации, который обнаруживает сложную внутреннюю структуру чудесного дара.

The paper deals with different situations of epic communication of South Siberian Turkic nations. It focuses mainly on inner descriptions, that is folk interpretations of the epic performance rather than on its external and factual descriptions. This approach makes it possible to take into account different folk texts about the acquisition of singer’s gift, it’s transmission and return. While analyzing these materials we discover a certain communication mechanism, which reveals the communicative structure of singer’s miraculous gift.
В.Ф. АСМУС: КОРРЕКТИВЫ К ОБРАЗУ
Authors: С.Н. Корсаков
Published: November 2022

В статье рассматривается несколько кейс-стади, связанных с жизнью и творческой деятельностью известного советского философа В.Ф. Асмуса. Проверяется степень обоснованности представления об особом нравственном статусе, который имел В.Ф. Асмус в истории философии в СССР. В качестве источников привлечены: воспоминания В.Ф. Асмуса о его детских годах, первая статья В.Ф. Асмуса, опубликованная в 1919 году и его работы второй половины 1920-х годов, когда он был сторонником философской школы А.М. Деборина, выступление В.Ф. Асмуса на заседании, посвящённом философским взглядам А.Ф. Лосева в Институте философии в 1930 году, выступление В.Ф. Асмуса на заседании в редакции журнала «Знамя» в 1936 г., где обсуждались итоги Первого Московского процесса.

The article discusses several case studies related to the life and creative work of the famous Soviet philosopher V.F. Asmus. Checks the degree of validity aware of the special moral status, which had a V.F. Asmus in the history of philosophy in the Soviet Union. In the sources analyzed: memories V.F. Asmus about his childhood years, the first article by V.F. Asmus, published in 1919, and his work in the second half of 1920-ies, when he was a supporter of the Deborin’s philosophical school, the speech of V.F. Asmus at the meeting, devoted to the philosophical views of A. F. Losev in the Institute of philosophy in 1930, the speech of V.F. Asmus at the meeting in the magazine “Znamya” in 1936, which discussed the results of the First Moscow trial.
ЗВУКИ МУЗЫКИ… ОБ ОСОБЕННОСТЯХ ИНДЕЙСКОЙ ФЛЕЙТЫ
Authors: Р. Брайэн
Published: November 2022

Публикуется авторизованный перевод статьи Рэндалла Брайэна о конструкционных особенностях флейты, созданной в стиле Woodland (NAF), сопровождаемый дополнительными комментариями.

An authorized translation of Randall Bryhn’s paper on the design of the Woodland Style Indian Flute (NAF) is published and commented.
HOW DIONYSUS GOT INTO PLATO'S DIALOGUES AND OCCUPIED SUCH AN IMPORTANT PLACE IN THEM?
Authors: Афонасина А.С.
Published: November 2022

В своих сочинениях Платон предлагает переосмыслить образы разных греческих богов, попутно создавая о них новые мифы. По большей части в его интерпретациях наблюдается тенденция к тому, чтобы представить богов в этически приемлемом виде, объявив, например, миф о преследованиях младенца Диониса со стороны Геры наглой ложью, ведь не может же у богини быть такой скверный нрав, или вывести два образа Афродиты, чтобы показать, что достойной уважения и высшей формой любви является духовная, а не телесная. Особого внимания заслуживает фигура Диониса, которому отводится важное место среди богов, почитаемых в идеальном государстве. У читателя может возникнуть справедливый вопрос — как известный в народе бог вина, веселья и безумия вдруг становится у Платона неотъемлемым инструментом в деле воспитания молодежи? Закрадывается подозрение, что Платон мог увидеть в Дионисе что-то такое, что, вероятно, ускользает от поверхностного взгляда простого обывателя. В этой статье мне хотелось бы обратиться к различным свидетельствам о Дионисе, которые помогут нам приоткрыть завесу тайны, и найти ответ на вопрос о том, какие элементы его мифа и культа дали Платону основание отвести Дионису довольно существенную роль в становлении идеального государства и доверить ему воспитание молодежи, что нашло отражение не только в политических диалогах, таких как «Государство» и «Законы», но и в диалогах, посвященных понимаю души и ее посмертному существованию — «Федон» и «Федр».

In his writings, Plato proposes to rethink the images of various Greek gods, creating new myths about them in the process. For the most part his interpretations tend to present the gods in an ethically acceptable way, declaring, for example, the myth of the persecution of the infant Dionysus by Hera as an impudent lie, because the goddess cannot have such a bad temper, or to bring out two images of Aphrodite to show that the spiritual, not the physical, is a respectable and the highest form of love. Of particular note is the figure of Dionysus, who is given a worthy place among the gods revered in the ideal state. One wonders, how does the popularly known god of wine, fun and madness suddenly become in Plato an important tool in the education of young people? A suspicion arises that Plato may have seen something in Dionysus that probably escapes the superficial gaze of an ordinary man. In this paper I am going to refer to different accounts of Dionysus, which will help us to unravel the veil of mystery, and find an answer to the question about what elements of his myth and cult gave Plato grounds to entrust Dionysus a very important role in the formation of the ideal state and trust him with education of youth, which is reflected not only in political dialogues, such as the “Republic” and the “Laws”, but also in the dialogues devoted to the understanding of the soul and its posthumous existence — the “Phaedon” and the “Phaedrus”.
A Bibliometric and Topic Modeling Overview of Kajian Malaysia Between 2011 and 2020: A Research Note
Authors:   School of Distance Education, Universiti Sains Malaysia, Pulau Pinang, Malaysia, Hilmi Mohd Faiz , Mustapha Yanti ,   Faculty of Business and Management, Universiti Teknologi MARA, Kedah, Malaysia
Published: November 2022

Kajian Malaysia, published by Penerbit Universiti Sains Malaysia, is an interdisciplinary journal which provides a forum for a broad range of social sciences and humanities research. This research note presents a bibliometric review of the articles published in the journal Kajian Malaysia between 2011 and 2020. The purpose of this research note is to evaluate publication patterns and the topic model of articles published in Kajian Malaysia. The bibliographical material applied in this study was retrieved from the Scopus database. This study bibliometrically examines 192 documents published in Kajian Malaysia from 2011 to 2020 to rank the most productive countries, institutions, authors, keywords, influential articles and the topic model. This research note assists researchers with an understanding of the development of Kajian Malaysia, provides an important reference for Kajian Malaysia’s future trajectory as well as provides an effective method of analysis for the future evaluation of journals.
Religious Tolerance Through the Lens of Halal Dining Experience in Malaysia
Authors:   Malaysia Immersion and Pathways, Monash University Malaysia, Selangor, Malaysia, Abdul Khalek Aiedah , Mohd Mokhtar Ros Aiza ,   Centre for Core Studies, Faculty of Leadership and Management, Universiti Sains Islam Malaysia, Negeri Sembilan, Malaysia
Published: November 2022

Religious tolerance is essential to develop a harmonious coexistence between members of a civilised multi-religious society. This notion is previously observed through a legal perspective, recognition and respect, as well as the absence of discrimination and religious conflict. However, this article looks at a different viewpoint, by utilising the dynamics of halal dining as an analytical tool to examine dimensions of religious tolerance. The study unpacks the religious tolerance experience in halal dining among Muslims and non-Muslims in Peninsular and East Malaysia. We compare the data of religious tolerance in halal dining from both Peninsular and East Malaysian experiences. Data was collected through quantitative surveys and interviews with Muslim and non-Muslim respondents. The findings show that Malaysians practise a high level of tolerance in dining with a few exceptions. These findings exhibit a new dimension of dining as a practical analytical tool, which might have hitherto been neglected in measuring religious tolerance within a multi-religious context.