bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KUALITAS PELAYANAN DAN HARGA TERHADAP KEPUASAN PASIEN PADA KELAS VIP, 1, 2, DAN 3 (STUDI PADA RSU PKU MUHAMMADIYAH GAMPING YOGYAKARTA)
Authors: Kurniawan Virdy , Susanto Susanto
Published: March 2024

This thesis examines the influence of service quality and price to patient satisfaction at the class VIP, 1, 2, and 3 in RSU PKU Muhammadiyah Unit 2 Gamping Yogyakarta. The issues examined are: there is influence of service quality and price to patient satisfaction simultaneously at class VIP, 1, 2 and class 3 in RSU PKU Muhammadiyah Unit 2 Gamping, there is influence of service quality dimensions to patient satisfaction individually at class VIP, 1, 2 and class 3 in RSU PKU Muhammadiyah Unit 2 Gamping, and there is influence of service prices on patient satisfaction individually at class VIP, 1, 2 and VIP 3 in RSU PKU Muhammadiyah Unit 2 Gamping.

This research is quantitative with the cross sectional study such as data collected only once. Data collected using questionnaires. Questionnaires carried out on 160 RSU PKU Muhammadiyah Unit 2 Gamping patients who are derived from the class VIP, class 1, 2, and class 3. Respondents determined by using convenience sampling who have stayed at PU Muhammadiyah Hospital Unit 2 Gamping at least 1 day.

From the study, it is found that there is significant effect of service quality and price simultaneously on patient satisfaction at class VIP, 1, 2 and 3 in RSU PKU Muhammadiyah Unit 2 Gamping. It is known from the results of the F test which is getting significant results for all classes at  µ (0,05). This means that hypothesis 1 proved (There is the influence of service quality and cost simultaneously on patient satisfaction at class VIP, 1, 2 and 3 in RSU PKU Muhammadiyah Unit 2 Gamping). There is significant influence of dimensions of service quality individually to patient satisfaction at class VIP, 1 , 2 and 3 in RSU PKU Muhammadiyah Unit 2 Gamping. It is known from the results of the F test which is getting significant results for all classes at µ (0,05). This means that hypothesis 2 proved (There is the influence of the dimensions of service quality individually on patient satisfaction at class VIP, 1, 2 and 3 in RSU PKU Muhammadiyah Unit 2 Gamping). In this case dimension that has a significant influence on the VIP is tangibles dimension, responsiveness and empathy (the most dominant is empathy). Dimensions that have a significant influence on the class 1 is responsiveness dimension and empathy (the most dominant is empathy). Dimensions that have a significant influence on the class 2 is all dimensions (the most dominant is reliability). Dimensions that have a significant influence on the class 3 is assurance dimension (the most dominant is assurance).

There is significant influence of price to patient satisfaction individually at class VIP, 2 and 3 in RSU PKU Muhammadiyah Unit 2 Gamping, except in patients class 1. It is known from the t test at µ (0,05).
ANALISIS BUDAYA KESELAMATAN PASIEN DI RSU PKU MUHAMMADIYAH, BANTUL
Authors: Wijaya Aris Suparman , Dewi Arlina , Dwita Della Mawros
Published: March 2024

Background: Patient safety culture in PKU Muhammadiyah Hospital of Bantul based on Putri (2010) in the category of enough. Though PKU Muhammadiyah Hospital of Bantul is a Class C has an obligation to implement the Patient Safety throughout the service area.

Method: This study used a mixed methods research approach is a quantitative method using cross sectional and qualitative methods with case study approach with a descriptive research design. Research subjects are nurses who deal directly with patients. A total of 61 people. Measurement of patient safety culture using a questionnaire from the AHRQ (Agency for Healthcare Research and Quality) in 2004 entitled HSOPSC (Hospital Survey on Patient Safety Culture). The questionnaire consisted of 12 questions dimensions with 42 items and is equipped with the interview data and report patient safety incidents from Patient Safety Team PKU Muhammadiyah Hospital, Bantul.

Results and Discussion: Patient Safety Culture at PKU Muhammadiyah Hospital of Bantul in the category of enough with a mean and median of 73.9. Still found gaps between the patient safety incident reporting patient safety teams and real in the field. As well as barriers to implementation of patient safety in PKU Muhammadiyah Hospital of Bantul is still not optimal support came from management, not optimal team performance because the work load and the persistence of blaming culture in the unit.
ANALISIS EKSTERNAL DALAM UPAYA PENGEMBANGAN MUTU PELAYANAN RAWAT INAP DI RSUD PANEMBAHAN SENOPATI BANTUL
Authors: Sari Fitra , Susanto Susanto
Published: March 2024

Background: Panembahan Senopati Hospital in Bantul as one government hospital in order to survive and be able to compete with other centers must be able  to develop it self according with quality demand. Effort to the win that competition can be done by improving service quality and providing services properly as expected by the customerThere for, Panembahan Senopati hospital need to have a quality plan by identifying their customer need to improve the quality services. Based on customer needidentification process, service quality development stretegies can be arranged.

Objectives: To know the gap between expectation and reality external customer for the quality of care in Panembahan Senopati Bantul Hospital, knowing the gap between expectation and reality of customer as an ingredient in developing a strategy of development of quality service in Panembahan Senopati Hospital.

Methods: The research is quantitative research with cross sectional design. The study was conducted on November 2013 in Panembahan Senopati Bantul Hospital. The sampel Obtained was 100 people. The sampling design is random sampling. The data analysis with defferent test average in pairs (t-test).

Result: The result showed that there are significant gaps between the average expectation and reality (p<0,05). The significant gap score on Class II there are dimension Emphaty  of nurse with gap=0,010. Class III and VVIP there is gap significant  in communication dimension with gap=0,049 andgap 0,011 and assurance dimension with gap= 0,001 on Class III. The significant gap score on Classn1there are dimension tangible with gap 0,016. While the other dimension  are not gap significant.

Conclusion: Quality of service in Panembahan Senopati Hospital for VVIP still does not meet customer expectations, then quality of service in Panembahan Senopati Hospital for class II and III still does  meet customer expectation.
PELAKSANAAN IDENTIFIKASI PASIEN BERDASARKAN STANDAR AKREDITASI JCI GUNA MENINGKATKAN PROGRM PATIENT SAFETY DI RS PKU MUHAMMADIYAH YOGYAKARTA UNIT II
Authors: Lestari Sri , 'Aini Qurratul
Published: March 2024

Penelitian ini mengungkap identifikasi pasien yang merupakan salah satu bagian penting dari keselamatan pasien. Akreditasi RS beralih dan berorientasi pada paradigma baru dimana penilaian akreditasi didasarkan pada pelayanan berfokus pada pasien. Keselamatan pasien menjadi indikator standar utama penilaian akreditasi baru yang dikenal dengan Akreditasi RS versi 2012. 1

Rancangan penelitian menggunakan eksperimen dengan one group pretest postest design dengan pretest, intervensi, dan postest. Metode penentuan sampel secara accidental, meliputi pasien rawat inap, perawat, bidan dan penunjang medis, melalui kuesioner, wawancara, pengamatan dan FGD. Hasil dianalisis secara statistik deskriptif dan deskriptif kualitatif.

Hasil penelitian menunjukkan bahwa identifikasi pasien belum dilakukan dengan baik, sesuai hasil kuesioner dan pengamatan masih ditemukan pasien rawat inap yang belum  menggunakan gelang identitas, 100% petugas belum memberikan edukasi tentang manfaat penggunaan gelang identitas pasien, dan 85% petugas belum melaksanakan identifikasi secara benar.  Pelaksanaan identifikasi berdasar  nama dan nomor kamar pasien. Walaupun sosialisasi, ronde patient safety, pemasangan poster identifikasi pasien telah di lakukan dan semua dokumen tentang identifikasi pasien telah lengkap.

Kesimpulanya pelaksanaan identifikasi di RS PKU Muhmmadiyah Yogyakarta belum berjalan sesuai standar. Saran yang disampaikan peneliti diantaranya ialah untuk memperbesar dukungan pihak managemen terutama dalam pemenuhan SDM, perubahan kebiasaan yang mendukung program patient safety oleh petugas.
Analysis of Vowel Sounds Errors in Arabic Conversation Modern Islamic Boarding School Muhammadiyah Daarul Khoir Gunungkidul Students
Authors: Hakim Farid Rochman
Published: March 2024

This study aims to determine the form of errors in the vowel sounds of Arabic words in the Arabic conversation of students at the Modern Muhammadiyah Islamic Boarding School Daarul Khoir Gunungkidul and to determine the factors that cause the occurrence of vowel errors. This research is a descriptive qualitative research. Data obtained by observing and interviewing students. The results of this study are four vowel errors, namely the change in vowel a to u. There is also a change in the vowel sound i to e. In addition, there were also errors in long vowel sounds which were pronounced short, even so short vowel sounds were pronounced long. The factors causing the error were that some students had not mastered Arabic rules correctly, made pronunciation easier, efficiency in pronunciation and the lack of students listening to Arabic words and sentences.
Investigation of the Physiological and Histopathological Effects of Omega Acids (3, 6, 9) and Stearic Acid on Rats in Ischemia Reperfusion
Authors: Karahan Tuğba , Arıhan Okan , Oto Gokhan , Yildirim Serkan , Kömüroğlu Ahmet Ufuk , Karahan Fatih
Published: March 2024

Ischemia causes reversible or irreversible cell or tissue damage due to insufficient blood flow to the organ or tissue. In this study, our aim is to investigate the protective effect of omega 3, 6 9 and stearic acid application before ischemia reperfusion injury in the leg muscles. For this purpose, 70 female albino rats were divided into 10 groups. The study continued at the same dose for 14 days. In addition, these fatty acids were given to other groups without ischemia-reperfusion. After the application different faty acid, blood biochemical parameters of different fatty acids, oxidative stress parameters and histopathology of tissues (liver, kidney, muscle) were examined in rats. As a result, it was observed that omega 9 fatty acid has better protective properties compared to other omega fatty acids and stearic acid in terms of histopathological properties and oxidative stress index. Additionally, other fatty acids and stearic acid provided some degree of protection against the deleterious effects of ischemia-reperfusion
Uncovering Engagement Profiles of Young Learners in K–8 Education through Learning Analytics
Authors: Er Erkan , Silik Safak , Cansiz Sergen
Published: March 2024

E-learning platforms have become increasingly popular in K–8 education to promote student learning and enhance classroom teaching. Student interactions with these platforms produce trace data, which are digital records of learning processes. Although trace data have been effective in identifying learners’ engagement profiles in higher education and lifelong learning (e.g., MOOCs), similar research on young learners has been very scarce. This study makes a timely and novel contribution to the field by identifying emerging profiles of young students from Grades 1 to 8 based on their engagement in an e-learning platform. The k-means cluster analysis yielded seven distinct profiles in total. While the dominance of profiles differed across grade levels, some profiles were not even present at specific grades, indicating the changing engagement behaviours of young learners in different years. In addition, all emerging profiles suggest students tended to focus on specific components of the platform, thus lacking balanced engagement with all resources. In particular, while primary school students showed relatively higher interest in game-based learning, middle school students focused more on exams than their counterparts. The findings yielded seven specific considerations for the design of effective e-learning platforms.
Comparison of diffusion MRI methods in the study of structural reorganization of the brain in the early post-stroke period
Authors: Stankevich Yu. A. , Karabanov I. S. , Popov V. V. , Bogomyakova O. B. , Tulupov A. A.
Published: March 2024

Current research in the field of neuroimaging is focused on the possibilities of using data from various diffusion MR models: diffusion tensor visualization (DTI), diffusion-curtosis visualization (DKI), diffusion-spectral visualization (DSI), generalized q-sample visualization (GQI), Q-ball visualization (QBI) in the assessment reorganization of the brain. The purpose of this study is to compare the results of dynamic observation of post–stroke brain reorganization by diffusion MR models (DTI, DKI). Material and methods. Dynamic MR examination of the brain of 129 patients was performed on a Ingenia 3.0 T (Philips, Netherlands) on 1–3 days, 7–10 days, 3–4 months after the manifestation of stroke according to a routine protocol (DWI-EPI, FLAIR-SPIR, T2-WI, T1W-TFE) with DTI method. The stroke was verified and DTI, GQI, and DKI maps were built. Results and discussion It was showed that the fractional anisotropy (FA) of DTI significantly changed from 1–3 days to 7–10 days in the stroke area; the mean, axial and radial diffusions increased in the affected area over the three studies. For DKI model – the curtosis FA significantly changed in the lesion area by 3–4 months; the mean curtosis decreased by the second observation in the stroke area, axial curtosis decreased in the same area throughout all studies; radial kurtosis significantly increased in the affected area throughout the study. The results confirm the world data and also indicate that diffusion metrics can interpret the neuroplasticity of the brain in various diseases, however, this requires further study. The applied diffusion models indicated the reorganization of the ischemic area and the intact contralateral area. The use of diffusion models for the dynamic assessment is a promising direction in the study of the neuroplasticity mechanisms.
Manajemen Pengembangan Kurikulum di Sekolah Dasar Islam
Authors: Nurlaela Latifah , Ulfah Maria , Farisi Mohammad Imam
Published: March 2024

School curriculum development management is a process that involves planning, organizing, implementing, and supervising a curriculum that meets the needs and objectives of education. The purpose of this study is to describe and analyze the curriculum development management in SDIP Masyithoh and SDIT Quantum Mulia. Data collection was conducted through interviews, observations, and document analysis. The data collected were analyzed thematically. To improve the validity of the data, the researcher used triangulation. The researcher ensured that this study complies with the applicable research ethics. SDIP Masyithoh and SDIT Quantum Mulia are two Islamic schools that have different approaches to curriculum development management. SDIP Masyithoh emphasizes on strengthening Islamic values and the development of academic skills, while SDIT Quantum Mulia emphasizes on the application of technology in learning, integration of subjects, and the development of students' global competencies. These different approaches are reflected in every stage of curriculum development management, starting from planning, organizing, implementing, supervising, and evaluating. SDIP Masyithoh approach emphasizes on strengthening Islamic values and the development of academic skills, which can help students become intelligent, faithful, and virtuous individuals. Meanwhile, SDIT Quantum Mulia approach emphasizes on the application of technology in learning, integration of subjects, and the development of students' global competencies, which can help students become intelligent, creative, and leadership-minded individuals.
Pengembangan Lembaga Paud Islam Dalam Perspektif Blue Ocean Strategy
Authors: Mulyani Novi , Wiyani Novan Ardy
Published: March 2024

This study aims to describe and analyze the development of Islamic PAUD institutions carried out by TK ABA Majapahit Kalierang Bumiayu Brebes in the perspective of blue ocean strategy. This research is a naturalist qualitative research. Data were collected using interviews, observation and documentation. Then the data were analyzed using the data analysis technique of the Miles and Huberman model. The results showed that the steps taken in implementing the blue ocean strategy to develop PAUD institutions in TK ABA Majapahit were: (1) Creating a canvas for the development of Islamic PAUD institutions; (2) Create a framework for Islamic PAUD institutions; (3) Create three levels of non-customer Islamic PAUD services; (4) Create a framework for six paths for the development of Islamic PAUD institutions; and (5) Creating the value of innovation in the provision of Islamic PAUD services.
The Effect of Appointment of Government Employees with Work Agreements on Teachers' Commitment
Authors: Santosa Achadi Budi
Published: March 2024

Organizational commitment is a form of employee loyalty in working in an organization. Recently, the phenomenon of turnover among private teachers has occurred frequently, especially after the government made a policy of hiring civil servants with work agreements. This study aims to examine the effect of job satisfaction and work motivation on organizational commitment in private schools in Bantul district. Through a quantitative approach, data collection was carried out by distributing questionnaires to teachers, then analyzed using multiple linear regression. The results show that; 1). there is a significant effect of job satisfaction on organizational commitment of 57.2%; 2). there is an effect of work motivation on organizational commitment of 26.2%; and 3). there is a simultaneous effect of job satisfaction and work motivation on organizational commitment of 71.9%. The suggestion from this study is that school principals need to maintain the commitment of teachers, especially those working in private educational institutions by increasing the job satisfaction factor.
Kırgız Kültüründe Hediyeleşme Geleneği ve İşlevleri
Authors: KİYAT Arzu
Published: March 2024

Hediye veya armağan sistemi arkaik dönemlerden beri var olan karmaşık bir yapı olarak süregelmiştir. Söz konusu hususta kavramın karşılıklılık ve karşılıksızlık ilkesine dayalı olması ve bu sebeple subjektif bir değerlendirmeye tabi tutulması yatmaktadır. Hediye kavramı; alma, verme ve karşılığını verme esasına dayalı üçlü bir döngü üzerine kurulu bir sistemdir. Bu sistem, arkaik devirlerde başlangıçta daha çok ticari sistem üzerine inşa edilmiş ve ticaret ortaklığına dayanan uzlaştırıcı bir araç olarak görülmüştür. Mefhum zamanla bu boyutlarından sıyrılarak anlam alanlarını genişletmiş ve gerek maddi gerek manevi içeriklerle çok boyutlu hâle gelmiştir. Hediye alma ve verme eylemi birey ve toplum üzerinde işlevsel etkiye sahiptir. Nitekim bu husus psikolojik, sosyal, kültürel, ekonomik, siyasi vb. pek çok noktada toplumdaki bireylere katkıda bulunmaktadır. Dolayısıyla işlevsellik ve pragmatik özelliğinin geniş perspektif imkân alanları sunması sistemin günümüze değin canlılığını koruyarak aktarılagelmesini sağlamıştır. Bu hususlar ekseninde hediye olgusunun Kırgız kültüründe mevcut durumunun hangi şekillerde olduğunu ortaya koymak önemli görülmüştür. Bu minvalde çalışmada, Kırgızlarda hediye kavramı ve hediyeleşme geleneğinin geçiş dönemi ritüellerinde işlevsel açılardan birey ve toplum üzerine olan etkileri değerlendirilmiştir. Sonuç olarak Kırgız kültüründe hediye ve hediyeleşme geleneğinin çeşitli tören ve kutlamalarda etkin biçimde sürdürüldüğü ve bu ritüellerdeki işlevsel görünümü dolayısıyla başta kültür ve geleneğin sürdürümcülüğü olmak üzere toplum üzerinde pek çok etkiye sahip olduğu belirlenmiştir.
Statistical analysis of the complete corpus of fiction in Russian and recognition of the author
Authors: Kislitsyna Maria Yurievna , Orlov Yurii Nikolaevich
Published: March 2024

Statistics of reference trigrams for the complete corpus of literary texts in Russian, including translated foreign authors, have been collected. Distributions of distances from individual texts to standards are constructed. The nearest reference method for recognizing the author of the text has been tested. The error was determined by genres, subgroups of authors and by the corpus as a whole. A classification of errors has been carried out to develop a correction method.
On the “mise-en-scène” of Pinoocchio 1940 and 2022 films' versions
Authors: Cha Mi Song , Ruslianti Atikah , Kusuma Dwi Linda
Published: March 2024

This study examines the film Pinocchio (2022) by Robert Zemeckis in comparison to the 1940 version of old animation on the basis of mise-en-scène. The analysis was done using the descriptive analysis method with the film approach and the films are analyzed on both the narrative and cinematographic aspect. The result showed that two films show a lot of similarities since they were both made on the same story. The analysis of the narrative aspect showed that they have different opening and conclusion in plot, have extra more characters in the new film, as well as show different social setting of the film. The cinematic examination proved that the new film put more details on the props of cuckoo clocks made by Geppetto and the lighting analysis showed that the 1940 version used constant high-key lighting while the new version used both low-key and high-key lighting. The 2022 version also used various camera angles and movements, while the 1940 version used constant standard camera angles throughout the film. The overall analysis showed that while the old version is made simply for young audiences, the new film targets audiences of not only young children, but also young adults.
Impacts and Implications of Macro Determinants Toward the Indonesian Sharia Stock Index
Authors: Rahman Akhlis Auliya , Widodo Syukri Fathudin Achmad , Andni Riyan , Muflih Betania Kartika
Published: March 2024

This study aims to analyze the effect of inflation, interest rates, exchange rates, and the Indonesian Composite Stock Price Index (IHSG) on the Indonesian Sharia Stock Index (ISSI), which is based on the inconsistencies of previous studies regarding inflation results, interest rate results, exchange rate results, as well as the results of the ISHG against the ISSI. This study uses a quantitative approach. The research data source uses secondary data in the first quarter of 2012 – fourth quarter of 2022 in the form of the closing price of the ISSI from https://www.ojk.go.id/ then the closing price for inflation, interest rates, exchange rates from https://www. ojk.go.id/ www.bi.go.id/, and the closing price of the Indonesian composite index from https://finance.yahoo.com/, which were processed using SPSS 26 software with multiple linear analysis. The results showed that inflation, interest rates, and exchange rates partially had no significant effect on the ISSI. Meanwhile, the IHSG had a significant effect on the ISSI. The variables of inflation, interest rates, exchange rates, and the IHSG simultaneously affect the ISSI. These results have implications for policymakers regarding the Islamic capital market.
Islamic Work Ethics in Thwarting Knowledge-Hiding Behavior among Organization Members
Authors: Abdillah Muhammad Rasyid , Anita Rizqa , Rahmat Adi , Zulhendra Zulhendra , Oemar Fahmi
Published: March 2024

Knowledge-hiding (KH) behavior is of particular concern in organizational and management studies because it can reduce the flow of knowledge and information in organizations. Thus, mechanisms that can minimize this behavior need to be identified, especially from an Islamic perspective. This study seeks to explain how Islamic work ethics may decrease or thwart employees from performing KH. In particular, the current study tries to explain the dual mediation mechanism that underlies this relationship, namely organizational citizenship behavior (OCB) and organizational commitment (OC). In order to verify the hypotheses, this study collected data from employees who work at Islamic banks in Pekanbaru City, Riau, Indonesia. Partial Least Square-Structural Equation Modeling (PLS-SEM) analysis was employed to verify the hypotheses proposed in the current study. This study revealed that Islamic work ethics can potentially limit or thwart workers from successfully performing their KH. Furthermore, this study found that organizational commitment and OCB mediate the mechanisms underlying the relationship.
Formulation of Teaching Materials for Environmental Pollution Based on Hybrid Learning to Develop Student Environmental Literacy
Authors: Nasution Ruqoyyah , Laelasari Iseu , Masitah Masitah , Visyam Vila Wahyu Ardila , Kartika Tyas Bella
Published: March 2024

Environmental literacy is a learning approach that utilizes the environment as a learning resource. This approach connects the environment in teaching and learning activities where the environment acts as a learning resource. Based on the results of the analysis in previous research, the researcher knows that the condition of the ability or literacy level of the student's environment is still classified as medium and low. There is still a low and moderate level of student environmental literacy, so efforts are needed to develop environmental literacy. Researchers assume that the development of these abilities can be built with teaching materials based on environmental literacy. This teaching material is used in Hybrid environmental pollution courses using MOLS (Mulawarman Online Learning System). This research is a type of development research with the ADDIE procedure or model (Analysis, Design, Development, Implementation, and Evaluation). This research was conducted at FKIP Mulawarman University for approximately 7 months. Starting from conducting environmental literacy tests to developing teaching materials in the environmental literacy domain. Based on the results of the material expert validation it is known that teaching materials get a feasibility score of 92.10%, and from the validation results the media experts get a score93.75%. So it can be concluded that the teaching materials developed in the domain of environmental literacy are very worth it to be used as a learning media.

Keywords: Hybrid Teaching Materials, Environmental Pollution, Environmental Literacy, the ADDIE model.
Development of Electronics Student Worksheet with Flip PDF Professional Based on Scientific Approach to Biodiversity Materials
Authors: Pangastuti Adha Ingga , Yustina Yustina , Daryanes Febblina
Published: March 2024

This study aims to produce an electronic student worksheet (E-LKPD) with Flip PDF Professional Based on a Scientific Approach to Biodiversity Material. The research was carried out at the Biology Education Study Program FKIP UNRI and at Pekanbaru  Public High School for students at Pekanbaru Public High School from July to September 2022. This type of research is research and development using the ADDIE and this research is limited to the development stage only. The instruments used were validation sheets and student response questionnaires with a likert scale. The results of this study indicate that the results of validation by the validator are in the very valid category with an average score of all aspects of 3.65. The results of the first phase trial obtained an average score of 3.61 and the results of the second phase trial obtained an average score of 3.58 in the very good category. Based on the research results of the E-LKPD with Flip PDF Professional based on a Scientific Approach on biodiversity material, it shows that the E-LKPD that has been developed is included in the very valid category
The Effect of Extraction Method on Total Flavonoid Content of Ageratum conyzoides Ethanol Extract
Authors: Wardhani Irma Yuniar , Ramadani Aisyah Hadi , Widyaningrum Fitri , Famelia Vena
Published: March 2024

This research is a type of comparative research using a quantitative approach. The study population was the population of Bandotan plants in the Kudus and Jepara regions. The organ parts taken from the plant were leaves, while the stems, roots and flowers were not extracted in this study. The extraction method used maceration and soxhletation with 96% ethanol solvent. Furthermore, to determine the total flavonoid content of Ageratum conyzoides leaf extraction results using the UV Vis Spectrophotometric method, it is known that Ageratum conyzoides leaf extract using the Soxhletation method has a higher total flavonoid content (0.32% b/v) compared to the Maceration method (0.22% b/v). The results of the total flavonoid test were then analyzed using the Mann Whitney U Test. Based on the Mann Whitney U Test shows that the value of Asymp. Sig. (2- tailed) of 0.102 > 0.05. Therefore, it can be concluded that there is no significant difference between maceration and soxhletation extraction methods on total flavonoids of Ageratum conyzoides extract.
The Influence of the 1988 and 2003 IOM Future of Public Health Reports on the CDC
Authors: Baker Edward L.
Published: March 2024

The landmark 1988 Institute of Medicine report The Future of Public Health served the public health community well by pointing to what needed to be done, fostering a sense of urgency, and offering concrete directions to be pursued.

In this article, the impact of the 1988 report, and of the subsequent 2003 report on the Centers for Disease Control and Prevention (CDC), is considered by tracing the course of the ideas that influenced the consciousness of the public health community and subsequently catalyzed concrete action. Among these ideas was that “public health is in disarray.” This assessment led to an awareness that something needed to be done. Further, by stating that the public health enterprise had 3 core functions (assessment, policy development, and assurance), the 1988 report set in motion policy development to address the “disarray.”

At a more fundamental level, both reports championed the need for governmental public health (particularly at the CDC) to take action to strengthen the capacity of local and state public health agencies to address a growing range of public health threats and emergencies. ( Am J Public Health. 2024;114(5):489–494. https://doi.org/10.2105/AJPH.2024.307598 )
Hexapod Frame Correction of Proximal Tibial Recurvatum Caused Indirectly by a Femoral Aneurysmal Bone Cyst in an Adolescent
Authors: Galán-Olleros María , Miranda-Gorozarri Carlos , Rey-Cañas Roberto , Alonso-Hernández Javier , Azorín-Cuadrillero Daniel , Palazón-Quevedo Ángel
Published: March 2024

Case:

A 16-year-old boy presented with a recurrent distal femur aneurysmal bone cyst accompanied by a combined sagittal knee deformity (20° of femoral antecurvatum and 26.8° of tibial recurvatum) and limb shortening. After preoperative planning, the treatment involved new intralesional curettage, phenolization, and bone allograft filling. Additional procedures included distal extension femoral osteotomy with plate fixation, and proximal tibial osteotomy with, gradually corrected through a hexapod frame. At 2-year follow-up, lower limbs exhibited normoalignment and equal length.

Conclusion:

Complex knee deformities may occur with tumoral lesions around the knee but can be effectively addressed through double osteotomy and application of a hexapod frame.
Frantz Tumor, a Rare Indolent Pancreatic Neoplasm Entity: A Case Report and Brief Review
Authors: Hoxha Faton , Musa Rrustem , Hashani Shemsedin , Mati Reshat , Hoxha Arb , Hoxha Nart , Terziqi Hasime , Ukëhaxhaj Antigona
Published: March 2024

Solid pseudopapillary neoplasm (SPN) of the pancreas, also known as Frantz tumor, is an uncommon tumor with indolent clinical features that primarily affects young women. We are presenting a 27-year-old Caucasian female with an accidental finding with pancreatic SPN who underwent complete resection of the tumor using a distal pancreatectomy and splenectomy procedure. Immunohistochemistry revealed low-grade pancreatic SPN. Despite the rare appearance, it should be considered in the differential diagnosis of a young female with a large pancreatic mass.
Knowledge, Attitudes, and Behaviors Toward Proper Nutrition and Lifestyles in Kosovar’s Diabetic Patients
Authors: Ukëhaxhaj A , Sutaj B , Terziqi H , Vrella A , Hoxha F
Published: March 2024

Background: The aim of our study was to assess the knowledge and attitudes about type 2 diabetes (T2D) in Kosovars patients, as well as self-efficacy toward eating behavior, and determine the impact of diabetes on patients' daily work and lifestyle practices.Methods and Results: This analytical cross-sectional survey was performed among 400 T2D patients (203 males and 197 females) to assess their knowledge, attitude, and practice regarding diabetic diet and eating habits. It was conducted from February to May 2023 in Kosovo's rural and urban areas. Knowledge, attitudes, and eating behavior were assessed using the self-administered 28-item sets related to glycemic control, physical activity, risk of complications, foot care, and food and nutrition. The largest proportion (42.3%) was made up of the patients over 60 years of age; 41.5% were 40-60 years of age, and only 16.3% were 30-40 years old. Most of the patients were males (50.8%); more than 87% were married. Interviewed participants did not have enough knowledge about the consumption of foods with more fruits, beverages, and sweets. Generally, participants had poor knowledge about the impact of DM on health. Most diabetics in Kosovo still have suboptimal diet practices, choosing to base their main meals around carbohydrates containing food with a high glycemic index, such as white bread and potatoes most of the time. In our case, 38.8% of participants never exercised during the week because they did not know the importance of exercise to treat their disease. In our study, we found no association between the level of diabetes-related knowledge and age, gender, or the years since the patient was diagnosed. A worrying fact for Kosovar patients is that there are no diabetes counseling centers in the regions where they live. Conclusion: There is a need to increase awareness of the complications of diabetes and consequently improve nutrition knowledge, attitudes, and practices. The benefits of early detection of T2D through screening in the general population are needed in Kosovo.
Prevalence of Antibiotic Prescription in Primary Healthcare Settings in the Municipality of Prishtina, Kosovo
Authors: Krasniqi Valon , Bahtiri Elton , Pasha Flaka , Zeqiri Vjollca , Uka Sami , Zarb Peter , Raka Lul , Bytyqi Hasime , Krasniqi Blana
Published: March 2024

Background: Antibiotics remain among the most prescribed drugs in primary healthcare, contributing to increased antibiotic resistance in the community and prevailing as an emerging global health concern. We aimed to quantify the prevalence and quality of antibiotic prescription in primary healthcare settings in the Municipality of Prishtina to identify targets for quality improvement.Methods and Results: This study represents a population-based, retrospective cohort, including data from eight randomly selected family medical centers in the Municipality of Prishtina. Each 150th patient on medical records was assessed for demographic data, diagnosis (ICD-10), antibiotic prescription, antibiotic class, and antibiotic form. In total, the study included 1614 cases reviewed. The antibiotic prescription rate was 16%. The health condition for which most of the cases received antibiotics was J18 - Pneumonia, unspecified organism (67%), followed by J03 - Acute tonsillitis (54%), J42 - Unspecified chronic bronchitis (46%), and N39 - Other disorders of the urinary system (43%) Broad-spectrum antibiotics, such as co-amoxiclav (17.7%), amoxicillin (16.5%), and ceftriaxone (12.6%), featured among the most routinely prescribed antibiotics. The antibiotic prescription rate was the highest for cases in the 3-5 age group, of whom 27% received an antibiotic prescription. In 73% of cases, oral antibiotics were prescribed, 69% of which belong to the WHO AWaRe (Access, Watch, Reserve) essential medicines list. Only 18% of antibiotics were prescribed with their generic names. Conclusion: The prevalence of antibiotic prescription in primary healthcare settings in Prishtina is moderately low. These data cannot be extrapolated to other municipalities in Kosovo or other countries due to different organizational levels. High antibiotic prescription rates for young age groups, prescription of broad-spectrum antibiotics, and high rates of parenteral antibiotics were identified as targets for quality improvement.
Botulinum Neurotoxin BoNT-A in the Management of Hypertrophic Scars and Keloids: A Comprehensive Review
Authors: Hussein Ramadan
Published: March 2024

Hypertrophic scars (HS) and keloids are challenging dermatological conditions that often lead to physical and psychological distress in affected individuals. Current therapeutic approaches have limitations, prompting the exploration of novel treatments. Botulinum Neurotoxin BoNT-A has emerged as a promising candidate in managing these scars. This comprehensive review delves into the pathophysiology of HS and keloids, the shortcomings of existing treatments, and the mechanisms underlying BoNT-A's potential efficacy. Through an analysis of clinical studies and evidence, the review evaluates BoNT-A's impact on scar formation and patient outcomes. Safety and side effects and the potential influence of BoNT-A on quality of life are also considered. Comparative analysis with traditional therapies underscores the advantages and challenges of BoNT-A use. The review concludes by suggesting future research directions and emphasizing the significance of Botulinum Neurotoxin BoNT-A as a promising therapeutic option. This article provides valuable insights for clinicians, researchers, and patients seeking innovative solutions for HS and keloids.
Aggregating the response in time series lag models using Quad weight kernel: Impact of Environmental Factors on Schizophrenia Admissions
Authors: Thomas Jobin , Parameswaran Murali
Published: March 2024

There has been a growing apprehension in the past few years concerning the issue of pollution and climate change. Several articles have shown the impact of air pollutants and atmosphere factors like temperature and relative humidity on health. This encompasses a deterioration in cognitive function and a heightened susceptibility to neurological diseases like Schizophrenia. This work constructed a new dataset for hospital admissions of schizophrenia patients and daily environmental values from various locations in Bangalore City, India. The Number of Admissions(NoA) to hospitals is used as a proxy for the incidence of schizophrenia emergence. In this kind of time series data where a response has a delayed impact on dependent variables, distributed lag models(DLM) are applicable. The newly created data is used to analyze the impact of pollution and climate factors on hospital admissions in Bengaluru, India. We have compared the applicability of the aggregated response technique using the Distributed lag non-linear Model(ARDLNM) in comparison with existing techniques, the Distributed lag non-linear Model and the Non-linear Auto regressive Distributed Lag Model(NARDL). ARDLNM using the Epanechnikov kernel showed improved performance over DLNM by 25%, 15%, 17% and 72% for performance metrics MSE, MAE, MAPE and R2 respectively. Within aggregation methods, we have introduced a quad-weight kernel that further improved performance over the Epanechnikov kernel by 17% in terms of MSE.
Characterization of vector elements and soluble expression of PCV3 cap protein in Kluyveromyces marxianus
Authors: Li Jiamei , Zheng Yueting , Yang Xuechen , Xu Mingyue , Yin Wenjing , Yang Guoyu , Zhang Wei
Published: March 2024

Due to thermotolerance and rapid growth yeast Kluyveromyces marxianus(K.marxianus) is emerging as a new platform organism for production of recombinant proteins. We constructed an expression vector to express exogenous proteins. Firstly, qPCR was used to validate the expression efficiency of endogenous promoters. Selecting PDC1 as the promoter to initiate the expression of EGFP for validation, the vector could successfully express foreign proteins. With Hygromycin in the medium the vector can accumulate in the cell. Further construction the cap of porcine circovirus type 3(PCV3) was carried out on the vector, and soluble PCV3 cap protein was obtained. Under electron microscopy, PCV3 cap formed viral like particles(VLP).This study successfully constructed the expression vector and elements of K.marxianus, which can further promote the research on the expression of exogenous proteins in K.marxianus. The soluble expression of PCV3 cap and formed VLP structure laid the foundation for further developing PCV3 vaccines.
Time to Intubate Utilizing Traditional Learning Versus Airway App with Augmented Reality
Authors: Gutierrez Mary Rachel , Skelton Caroline , Smiley-Naughton Cathy
Published: March 2024

Background: Endotracheal intubation is a fundamental skill for anesthesia providers and any healthcare provider tasked with securing the airway. Despite the clinical significance, this skill continues to be a challenging procedure for novice Student Registered Nurse Anesthetists (SRNAs) to master. Current training modalities fail to account for the dynamic changes experienced in live patients. The purpose of this project is to evaluate whether Augmented Reality (AR) airway applications reduce the time to endotracheal intubation in novice learners.
Methods: Research methods include searching databases, such as PubMed, Web of Science, and CINAHL, and narrowing results with keywords, inclusion, and exclusion criteria. The study design used in this research project can be classified as an evidence-based intervention or quality improvement initiative. The population of this study included first-year Student Registered Nurse Anesthetists (SRNA) and Emory University. The researchers analyzed time to intubation before and after augmented reality (AR) interactive education on the Airway Ex app.
Results: The median time Pre-AR was 14.22 seconds and Post-AR was 13.55 seconds. The Wilcoxon Signed Ranked Test with a two-tailed significance value of 0.394 indicates that these results are not statistically significant. The surveys demonstrated improved confidence in DL skills post AR, better understanding of patient airway anatomy, enhanced learning experience, and most participants reported ease of use of AR as an education modality.
Conclusions:This study highlights the potential of utilizing AR in the training of novice SRNAs. There is a need for additional research with a larger sample size to establish statistical significance and further evaluate this novel training modality.
Case report: Response to immunotherapy and Association with FH gene in Hereditary Leiomyomatosis and Renal Cell Cancer Associated Renal Cell Carcinoma
Authors: Gao Fangfang , Gu Dejian , Zhang He , Shi Chao , Du Feng , Zheng Bo , Wu Huijuan , Zhao Yanqiu
Published: March 2024

Hereditary leiomyomatosis and renal cell cancer (HLRCC) was a rare autosomal dominant syndrome caused by germline mutation in the fumarate hydratase (FH) gene; it manifestsas cutaneous leiomyomas, uterine fibroids, and renal cell cancer (RCC). Patients with HLRCC-associated RCC (HLRCC-RCC) had aggressive clinical courses, but there was no standardized therapy for advanced HLRCC-RCC. In this study, we described an aggressive HLRCC in a 33-year-old female who exhibited a novel heterozygous germline insertion mutation in exon 8 of the FH gene (c.1126C>T; p.Q376*). The patient underwent laparoscopic resection of the right kidney, but metastases appeared within 3 months postoperatively. Histological staining of the resected tumor showed high expression levels of programmed cell death-ligand 1 (PD-L1). Therefore, the patient was treated with immunotherapy. The patient achieved partial response in immunotherapy and metastatic lesions had continued to benefit until now. A review of the literature identified 76 previously reported cases of HLRCC-related RCC in immunotherapy and 46 patients were enrolled in this study to analysis the correlation of FH gene and efficacy of immunotherapy. Our results indicated that the different mutations of FH germline gene were not affect efficacy of immunotherapy and immunotherapy could significantly improve the OS of HLRCC patients. Therefore, our study suggested that immunotherapy treatment was an effective therapeutic option for patients with HLRCC regardless of what form of FH germline mutation.
SPIRED-Fitness: an end-to-end framework for the prediction of protein structure and fitness from single sequence
Authors: Gong Haipeng , Chen Yinghui , Xu Yunxin , Liu Di , Xing Yaoguang
Published: March 2024

Significant research progress has been made in the field of protein structure and fitness prediction. Particularly, single-sequence-based structure prediction methods like ESMFold and OmegaFold achieve a balance between inference speed and prediction accuracy, showing promise for many downstream prediction tasks. Here, we propose SPIRED, a novel single-sequence-based structure prediction model that exhibits comparable performance to the state-of-the-art methods but with approximately 5-fold acceleration in inference and at least one order of magnitude reduction in training consumption. By integrating SPIRED with downstream neural networks, we compose an end-toend framework named SPIRED-Fitness for the rapid prediction of both protein structure and fitness from single sequence. SPIRED-Fitness and its derivative SPIRED-Stab achieve state-of-the-art performance in predicting the mutational effects on protein fitness and stability metrics, respectively.
Production of carbon-11 for PET preclinical imaging using a high-repetition rate laser-driven proton source
Authors: Peñas Juan , Alejo Aaron , Bembibre Adrián , Apiñaniz Jon Imanol , García-García Enrique , Guerrero Carlos , Henares José Luis , Hernández-Palmero Irene , Méndez Cruz , Millán-Callado María Ángeles , Puyuelo-Valdés Pilar , Seimetz Michael , Benlliure José
Published: March 2024

Most advanced medical imaging techniques, such as positron-emission tomography (PET), require tracers that are produced in conventional particle accelerators. This paper focuses on the evaluation of a potential alternative technology based onlaser-driven ion acceleration for the production of radioisotopes for PET imaging. We report for the first time the use of ahigh-repetition rate, ultra-intense laser system for the production of carbon-11 in multi-shot operation. Proton bunches with energies up to 10 – 14 MeV were systematically accelerated in long series at pulse rates between 0.1 and 1 Hz using a PW-class laser. These protons were used to activate a boron target via the 11B(p,n)11C nuclear reaction. A peak activity of 234 kBq was obtained in multi-shot operation with laser pulses with an energy of 25 J. Significant carbon-11 production was also achieved for lower pulse energies. The experimental carbon-11 activities measured in this work are comparable to the levels required for preclinical PET, which would be feasible by operating at the repetition rate of current state-of-the-art technology (10Hz). The scalability of next-generation laser-driven accelerators in terms of this parameter for sustained operation over time could increase these overall levels into the clinical PET range.