bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthetic turf finite element model development and validation
Authors: Bustamante Michael C , Watson Brock , Correia Matheus A , Rycman Aleksander L , Yoder Jared , O’Cain Cody , Park Gwansik , Aldahir Philipe , Spratley Meade , Cronin Duane S
Published: February 2024

Assessment of synthetic turf performance has been undertaken using a variety of experimental methods but is limited in understanding the complex physics of cleat-turf interaction. Computational models could provide insight, but there is currently no validated model of synthetic turf available. The scope of this study was to develop a Finite Element (FE) model of synthetic turf using a hierarchical approach and validate the model using independent test data. A physical third-generation synthetic turf comprising slit-film fibers with sand and rubber crumb infill was constructed. Experiments were conducted using a direct impact (Clegg) device and an artificial cleat-form. Material characterization tests were performed on the individual turf components, integrated into constitutive models, and a full turf FE model was constructed. The carpet was modeled with shell elements while the granular infill was modeled using smoothed-particle hydrodynamics (SPH) elements. A method to simulate the physical pre-conditioning performed on the experimental turf was developed. Both unconditioned and pre-conditioned turfs were assessed using Clegg tests. The re-created Clegg tests on the turf model demonstrated good agreement with the physical tests, with higher acceleration for the pre-conditioned turf. The turf model was validated using experiments with a turf test apparatus including dynamic translation and rotation of a cleat-form. The model predicted results in good agreement with the experiments (average CORA rating of 0.863) on pre-conditioned turf. The resulting model and methods can be expanded to synthetic turf of different constituent materials, to investigate their effects on cleat-surface interaction, optimizing performance, and reducing injury risk.
Conscious of Christ: Toward a Doctrinal Mysticism in Dialogue With Bernard McGinn, John Calvin, and Meister Eckhart
Authors: Shuler Bryan
Published: February 2024

While mysticism can at times be viewed with skepticism by Protestants, recent research by Bernard McGinn suggests that it is often misunderstood. As such, mysticism deserves an honest appraisal concerning its biblical merit, and doing so reveals that “doctrinal mysticism,” in which the “mystical element of Christianity” is guided by Scripture and doctrine, can and should be applied within a Christian’s life as an aid in spiritual growth and vitality. The application of McGinn’s heuristic definition of “mysticism” to the mystical elements of Meister Eckhart’s and John Calvin’s works, along with a Scriptural critique of their positions, shows the spiritual benefits of doctrinal mysticism and the necessity of developing a conscious awareness of the presence of God in one’s spiritual life.
Mindfulness Practice Is Associated With Improved Well-Being and Reduced Injury Risk in Female NCAA Division I Athletes
Authors: Haraldsdottir Kristin , Sanfilippo Jennifer , Anderson Scott , Steiner Quinn , McGehee Chad , Schultz Kevin , Watson Andrew
Published: February 2024

Background:

Injury in sport is an inherent risk to participation, and it can have devastating consequences for the athlete, both mentally and physically. Previous research has found that impairments in well-being can increase the risk of injury, and that various forms of mindfulness training and practice can improve well-being and mental health in various populations.

Hypothesis:

Mindfulness would be associated with greater well-being and lower risk of injury.

Study Design:

Cohort study.

Level of Evidence:

Level 3.

Methods:

A total of 21 female Division I athletes underwent a formal 6-week mindfulness training program and were encouraged to continue mindfulness exercises. The athletes completed daily surveys on their smartphones in relation to mood, muscle readiness (soreness), readiness to train, energy level, daily training load, and whether they had participated in mindfulness training that day. Linear mixed effects models were used to evaluate well-being variables and mindfulness state, and separate mixed effects logistics regression models were used to evaluate injury incidence and wellness variables.

Results:

On days with mindfulness practice, athletes reported higher mood (19.6 [18.8-20.3] vs 19.4 [18.6-20.1, P = 0.03), muscle readiness (18.9 [17.8-20.0] vs 18.6 [17.5-19.6], P = 0.03), readiness to train (78.7 [75.9-81.5] vs 77.4 [74.7-80.2], P < 0.01), and energy level (19.3 [18.6-20.1] vs 18.8 [18.1-19.5, P < 0.01) than on the days when they did not participate in mindfulness training. Mindfulness practice was associated with significantly reduced likelihood of suffering an acute injury the following day (odds ratio, 0.42; 95% CI, 0.42-0.43; P < 0.01).

Conclusion:

On an individual level, participation in mindfulness by female collegiate athletes was associated with a dramatic reduction in injury risk the following day. In addition, mindfulness was associated with significantly improved mood, muscle readiness, readiness to train, and energy level.

Clinical Relevance:

These findings suggest that mindfulness training in athletes may improve well-being and reduce the risk of injury among high-level athletes.
Temperamental and Neuropsychological Predictors for Major League Pro-Baseball Success
Authors: Kim Kun Jung , Chung Sung Ah , Lee Sun Jae , Han Doug Hyun
Published: February 2024

Background:

Securing a professional baseball career is a formidable task, and only a unique few can overcome the obstacles necessary to become a Major League player in the Korea Baseball Organization (KBO). When achieving a spot in a KBO Major League team, a player’s technical aspect may be influenced by their initial neuropsychological status.

Hypothesis:

Personality and neurocognitive functions influence long-term pro-baseball league success.

Study Design:

Cohort observational study.

Level of Evidence:

Level 3.

Methods:

From the start of each player’s career, we monitored the status and course of 153 baseball players in the KBO from 2009 to 2019 who agreed to participate in this study. The Korean versions of the Temperament and Character Inventory (TCI) and the State-Trait Anxiety Inventory-Y (STAI-KY) analyzed traits and estimated state and trait anxiety levels, respectively. The Trail Making Test (TMT) (parts A and B) assessed attention shifting, and, in the Wisconsin Card Sorting Test (WCST), perseverative errors determined cognitive flexibility. Hierarchical logistic regression models were used to predict player status variables, with TCI and neurocognitive function variables as covariates.

Results:

High novelty-seeking scores, low state anxiety, and short TMT A results reliably predict KBO Major League participation in a player’s third year. Similarly, low state anxiety scores and high harm avoidance, reward dependence, and self-transcendence scores accurately predict KBO Major League participation in a player’s fifth year. Lastly, short TMT A results, low perseverative error scores, and high novelty-seeking, harm avoidance, reward dependence, and self-transcendence efficiently predict KBO Major League participation in a player’s seventh year.

Conclusion:

Draft ranking, personality, and neurocognitive function are associated with pro-baseball league achievement. In particular, personality and neuropsychological functions are associated with long-term success.

Clinical Relevance:

Clinically, sound personality and neuropsychological functions determine KBO Major League success.
The Topics of Nostalgic Recall: The Benefits of Nostalgia Depend on the Topics That One Recalls
Authors: Fetterman Adam K. , Evans Nicholas D. , Ravey Eriksen P. , Henderson Perla R. , Tran Bao Han L. , Boyd Ryan L.
Published: February 2024

This research explores the intricate realm of nostalgia, employing advanced language analysis and the Event Reflection Task to systematically dissect the process of nostalgic recall. Through this methodological approach, distinct thematic elements are identified across 10 data sets ( N = 2,038). Eight recurrent topics in nostalgic content are unveiled, ranging from Family and Positive Affect to Longing and Place. The interplay of these thematic categories with the psychological consequences of nostalgia reveals a complex and multifaceted pattern. Notably, themes associated with positive affect exhibit a capacity to yield a plethora of favorable psychological outcomes, while those intertwined with negative emotion are bittersweet. This investigation paves the way for inquiries into potential cross-cultural disparities, the diversification of manipulation techniques, and the application of sophisticated analytical methodologies. As nostalgia’s dimensions continue to unfold, its implications widen, inviting researchers to unearth the profound depths of emotion and cognition entwined in the reverie of reminiscence.
Promoting Reproducibility and Replicability in Political Science
Authors: Brodeur Abel , Esterling Kevin , Ankel-Peters Jörg , Bueno Natália S. , Desposato Scott , Dreber Anna , Genovese Federica , Green Donald P. , Hepplewhite Matthew , Hoces de la Guardia Fernando , Johannesson Magnus , Kotsadam Andreas , Miguel Edward , Velez Yamil R. , Young Lauren
Published: February 2024

This article reviews and summarizes current reproduction and replication practices in political science. We first provide definitions for reproducibility and replicability. We then review data availability policies for 28 leading political science journals and present the results from a survey of editors about their willingness to publish comments and replications. We discuss new initiatives that seek to promote and generate high-quality reproductions and replications. Finally, we make the case for standards and practices that may help increase data availability, reproducibility, and replicability in political science.
Rejection of Fecal Immunochemical Tests Within the Lower Gastrointestinal Diagnostic Pathway: A Cohort Study
Authors: Ball Alex J. , Aziz Imran , Sargur Ravishankar B. , Merriman Louise , Kurien Matthew
Published: February 2024

Introduction/Objectives:

The fecal immunochemical test (FIT) helps triage primary care patients at risk of colorectal cancer (CRC). Improving FIT returns has received recent attention, however uncertainty exists regarding the accurate completion of samples provided for laboratory analysis. This study aims to identify the rejection rate of returned FIT samples and determine rejection causes.

Methods:

FIT samples from symptomatic patients within South Yorkshire, Bassetlaw, and North Derbyshire are processed at a central laboratory. Tests requests are made from 225 GP practices, which serve an estimated 2 million population. This study describes a retrospective review of FIT samples received in the central laboratory between 01/09/19 and 31/12/22. Locally held data was interrogated in March 2023 to determine the number of FIT samples received and rejected during the study period. Documented reasons for rejection were explored to identify common themes.

Results:

Total FIT specimens received during the study period was 126 422. Of these, 5190 (4.1%) were rejected. Monthly rejection rates fell from 17.4% in September 2019 to 1.3% in December 2022 ( P < .001). Sampling errors were the most frequent cause for FIT rejection (2151/5190), with other causes including: expired specimen; no sample collection date/ time, no request form, incomplete patient information and illegible handwriting.

Conclusions:

This is the first study exploring FIT rejection rates in symptomatic primary care patients, which shows improvements in rejection rates over time. Targeted interventions could improve rejection rates further, thereby reducing NHS resource use and costs and diagnostic delays.
Palestine’s Great Flood: Part I
Authors: Ajl Max
Published: February 2024

This is the first part of a two-part article which considers the US-Israeli attack on Palestine in general and the Gaza Strip in particular in a world-historical and regional context. In contrast to a range of theories which resort to liberal international relations theory, economism, or methodological nationalism when theorizing accumulation in general or Arab region accumulation in particular, the article argues that the Arab-Iranian region is under a regime of US-imposed de-development which seeks to dismantle strategic obstacles in the region through war and sanctions. The article argues this process encountered an obstacle amidst Iranian-linked regional militia and standing armies, and that these forces need to be understood by revisiting thinking about the role of political sovereignty in emancipatory transitions.
Entrepreneurial Mindsets & Rhetorical Canons: Enhancing Business Communication Pedagogy via Cross-disciplinary Theory, Praxis
Authors: Burks Josie A. , Armstrong Craig E.
Published: February 2024

Business and professional communication courses hold special opportunities to contribute to students’ development of entrepreneurial mindsets through the use and extension of classical rhetorical theory and praxis. We situate pedagogical activities within the context of the entrepreneurial venture pitch by using Rhetorical Canons of invention, arrangement, style, memory, and delivery to develop oral discourse while recognizing and developing entrepreneurial mindsets. We utilize elements of entrepreneurial mindset development presented by Kuratko et al. and Daspit et al. to introduce business and professional communication instructors to cognitive, behavioral, and emotional aspects contributing to the establishment of entrepreneurial mindsets.
Shifting Tides: The Evolution of Racial Inequality in Higher Education from the 1980s through the 2010s
Authors: Oh Byeongdon , Tilbrook Ned , Shifrer Dara
Published: February 2024

Amid the proliferation of state-level bans on race-based affirmative action in higher education, the U.S. Supreme Court’s decision on June 29, 2023, dismantled race-conscious college admission policies, intensifying concerns about the persistence and potential increase of racial inequality in higher education. The authors analyze four restricted-use national survey datasets to investigate racial disparities in college attendance outcomes from the 1980s through the 2010s. Although college entrance rates increased for all racial groups, Black and Hispanic youth became increasingly less likely than their White peers to attend four-year selective colleges. In the 2010s cohort, Black and Hispanic youth were 8 and 7 percentage points, respectively, less likely than their White counterparts to secure admission to four-year selective colleges, even after controlling for parents’ income, education, and other family background variables. The findings underscore the urgent need for proactive policy interventions to address the widening racial inequality in attending selective postsecondary institutions.
Normology: Is it Time to Rethink Point-of-Care Ultrasound Training?
Authors: Dupriez Florence , Jarman Robert David
Published: February 2024

Point-of-care ultrasound (PoCUS) is increasingly being adopted by clinicians to augment their clinical examination and aid procedures. Evidence-based clinical practice guidelines now support many aspects of PoCUS practice. As a result, more and more medical schools are integrating PoCUS into their curricula, creating a significant demand for training resources. All training must ensure that trainees have the appropriate knowledge, skills and behaviour to enable the clinical integration of PoCUS. The transition from supervised to unsupervised practice is an important step in PoCUS, but should not be confused with expertise. At the start of clinical practice, confirming that something is not normal is probably enough, and trainees can subsequently improve their PoCUS diagnostic accuracy at the bedside during clinical rotations. Our hypothesis is that competency can be achieved without the need to scan patients suspected or suffering from the target pathology. This would enable most of the training to be carried out outside the clinical environment, using volunteers in planned sessions. These planned sessions will be able to accommodate a larger number of trainees and may facilitate collaboration between specialties. When patients are scanned in the clinical environment, trainees should have acquired a good level of competence beforehand. In summary, normology principles could help PoCUS trainees, at the start of their training, to acquire the knowledge, skills and behaviour necessary to achieve a level of competency allowing them to proceed to unsupervised practice. Initially confirming whether something is normal or not is enough. Nevertheless, further research should be conducted to support this concept, and its impact on PoCUS teaching in clinical practice.
Swiss trial of decompressive craniectomy versus best medical treatment of spontaneous supratentorial intracerebral haemorrhage (SWITCH): an international, multicentre, randomised-controlled, two-arm, assessor-blinded trial
Authors: Fischer Urs , Fung Christian , Beyeler Seraina , Bütikofer Lukas , Z’Graggen Werner , Ringel Florian , Gralla Jan , Schaller Karl , Plesnila Nikolaus , Strbian Daniel , Arnold Marcel , Hacke Werner , Jüni Peter , Mendelow Alexander David , Stapf Christian , Al-Shahi Salman Rustam , Bressan Jenny , Lerch Stefanie , Bassetti Claudio L. A. , Mattle Heinrich P. , Raabe Andreas , Beck Jürgen
Published: February 2024

Rationale:

Decompressive craniectomy (DC) is beneficial in people with malignant middle cerebral artery infarction. Whether DC improves outcome in spontaneous intracerebral haemorrhage (ICH) is unknown.

Aim:

To determine whether DC without haematoma evacuation plus best medical treatment (BMT) in people with ICH decreases the risk of death or dependence at 6 months compared to BMT alone.

Methods and design:

SWITCH is an international, multicentre, randomised (1:1), two-arm, open-label, assessor-blinded trial. Key inclusion criteria are age ⩽75 years, stroke due to basal ganglia or thalamic ICH that may extend into cerebral lobes, ventricles or subarachnoid space, Glasgow coma scale of 8–13, NIHSS score of 10–30 and ICH volume of 30–100 mL. Randomisation must be performed <66 h after onset and DC <6 h after randomisation. Both groups will receive BMT. Participants randomised to the treatment group will receive DC of at least 12 cm in diameter according to institutional standards.

Sample size:

A sample of 300 participants randomised 1:1 to DC plus BMT versus BMT alone provides over 85% power at a two-sided alpha-level of 0.05 to detect a relative risk reduction of 33% using a chi-squared test.

Outcomes:

The primary outcome is the composite of death or dependence, defined as modified Rankin scale score 5–6 at 6 months. Secondary outcomes include death, functional status, quality of life and complications at 180 days and 12 months.

Discussion:

SWITCH will inform physicians about the outcomes of DC plus BMT in people with spontaneous deep ICH, compared to BMT alone.

Trial registration:

ClinicalTrials.gov Identifier: NCT02258919
Spaces of in/formality in the Turkish humanitarian field: Spatial and discursive practices impacting refugee women
Authors: Erman Tahire , Zadhy-Çepoğlu Aminath Nisha
Published: February 2024

Drawing upon critical feminist theorising, this article intervenes in the debates about humanitarian aid organisations in the case of urban refugees to highlight the ubiquity of in/formal practices in their interlinkedness that increasingly shape aid distribution. By examining humanitarian enactments at three levels –the national, the district and the neighbourhood– in the case of Ankara, Turkey, the article advances theoretical discussions about how formality and informality are intertwined as spatial techniques and discursive practices are deployed justifying in/formality in practice. We argue that such spatial and discursive interventions have become normalised as local aid distributors seek legitimacy in a contested process to counteract their image as unregulated. By centring the experiences of urban refugee women and their engagement with in/formal humanitarian practices, we expose the gendered connotations underpinning these interventions at the three levels of humanitarian enactments as (1) detached paternalism at the national level creating refugee women’s alienation, (2) a culture of Islamic charity at the district level prompting gendered performances of victimhood and (3) patriarchal ideology of male saviours linked to Islam at the neighbourhood level disciplining refugee women and leading to their (sexual) exploitation. In doing so, we problematise spatial and discursive modalities of in/formality, which produce profoundly gendered precarities, causing refugee women’s subordination in multiple ways. Bringing attention to how in/formality− as a part of contemporary conditions of refugeehood− interacts with gender, and how legitimacy is attained through on-the-ground spatial techniques coupled with discourses, we contribute to a more sophisticated understanding of the humanitarian field.
Folk Horror and Witchcraft: Exploring the Rhetoric of Tribal Evil Tradition and Marginalization of Women in Baso-jhi by Sowvendra Sekhar Hansda and Reincarnation of Parasuram by Anil Ghorai
Authors: Bera Santanu
Published: February 2024

Sowvendra Sekhar Hansda, a writer from Jharkhand and an ethnic member of the Santhal community, and Anil Ghorai, a Bengali writer have come forward with their powerful literary oeuvre to bring to the surface the helpless agonies of marginalized subalterns and Adivasi women and allow them a voice against the oppression and violence. Both the writers possess extraordinary knowledge and firsthand experience of tribal culture, tradition and practices. They were very much conscious about the bleak ground reality of oppression and abashment practiced either by the money-minded bourgeois class in the name of progress or by the rest of the society under casteism. And when this subjugation comes to the women, different layers began to be added. The most exploited and primitive weapon in this regard comes in the version of witchcraft, black magic and sorcery within their segregated society and which is already fighting against so much odds. The present article attempts a critical appraisal of ‘Baso-jhi’ by Sowvendra Sekhar Hansda and ‘Reincarnation of Parasuram’ by Anil Ghorai to bring to the surface the layered patriarchal marginalization of women within their community and the menace that this barbaric practice of witch hunt exercises upon womenfolk and finally the horror that embodies the entire folk existence.
Understanding Meta-Analysis Through Data Simulation With Applications to Power Analysis
Authors: Gambarota Filippo , Altoè Gianmarco
Published: February 2024

Meta-analysis is a powerful tool to combine evidence from existing literature. Despite several introductory and advanced materials about organizing, conducting, and reporting a meta-analysis, to our knowledge, there are no introductive materials about simulating the most common meta-analysis models. Data simulation is essential for developing and validating new statistical models and procedures. Furthermore, data simulation is a powerful educational tool for understanding a statistical method. In this tutorial, we show how to simulate equal-effects, random-effects, and metaregression models and illustrate how to estimate statistical power. Simulations for multilevel and multivariate models are available in the Supplemental Material available online. All materials associated with this article can be accessed on OSF ( https://osf.io/54djn/ ).
Diagnosing the Misuse of the Bayes Factor in Applied Research
Authors: Tendeiro Jorge N. , Kiers Henk A. L. , Hoekstra Rink , Wong Tsz Keung , Morey Richard D.
Published: February 2024

Hypothesis testing is often used for inference in the social sciences. In particular, null hypothesis significance testing (NHST) and its p value have been ubiquitous in published research for decades. Much more recently, null hypothesis Bayesian testing (NHBT) and its Bayes factor have also started to become more commonplace in applied research. Following preliminary work by Wong and colleagues, we investigated how, and to what extent, researchers misapply the Bayes factor in applied psychological research by means of a literature study. Based on a final sample of 167 articles, our results indicate that, not unlike NHST and the [Formula: see text] value, the use of NHBT and the Bayes factor also shows signs of misconceptions. We consider the root causes of the identified problems and provide suggestions to improve the current state of affairs. This article is aimed to assist researchers in drawing the best inferences possible while using NHBT and the Bayes factor in applied research.
The Case for Early Transition-Planning for Students With Significant Support Needs: Implications for Policy and Practice
Authors: Williams Crystal S. , Price Richard A.
Published: February 2024

The period in which young adults transition from high school is accompanied with complexities they need to navigate, such as further education and training, independent living, developing their career, and achieving meaningful employment. All of these set the stage for a successful and independent life. The significance of this transition is paramount; however, in research and practice, we continue to see poor outcomes for students with disabilities, especially those with the most significant support needs. Transition planning, mandated by the Individuals with Disabilities Education Act, must begin no later than a child turning 16. Some states mandate transition activities to start as early as 14, but should we consider an even earlier age? Within this paper, we discuss the need for changes within policy and practice to begin transition activities during children’s early education years.
Genomes for Nurses: Understanding and Overcoming Barriers to Nurses Utilizing Genomics
Authors: Hines-Dowell Stacy , McNamara Elizabeth , Mostafavi Roya , Taylor Leslie , Harrison Lynn , McGee Rose B. , Blake Alise K. , Lewis Sara , Perrino Melissa , Mandrell Belinda , Nichols Kim E.
Published: February 2024

Background: Genomic testing is an increasingly important technology within pediatric oncology that aids in cancer diagnosis, provides prognostic information, identifies therapeutic targets, and reveals underlying cancer predisposition. However, nurses lack basic knowledge of genomics and have limited self-assurance in using genomic information in their daily practice. This single-institution project was carried out at an academic pediatric cancer hospital in the United States with the aim to explore the barriers to achieving genomics literacy for pediatric oncology nurses. Method: This project assessed barriers to genomic education and preferences for receiving genomics education among pediatric oncology nurses, nurse practitioners, and physician assistants. An electronic survey with demographic questions and 15 genetics-focused questions was developed. The final survey instrument consisted of nine sections and was pilot-tested prior to administration. Data were analyzed using a ranking strategy, and five focus groups were conducted to capture more-nuanced information. The focus group sessions lasted 40 min to 1 hour and were recorded and transcribed. Results: Over 50% of respondents were uncomfortable with or felt unprepared to answer questions from patients and/or family members about genomics. This unease ranked as the top barrier to using genomic information in clinical practice. Discussion: These results reveal that most nurses require additional education to facilitate an understanding of genomics. This project lays the foundation to guide the development of a pediatric cancer genomics curriculum, which will enable the incorporation of genomics into nursing practice.
Clinical features of migraine with aura: a REFORM study
Authors: Thomsen Andreas Vinther , Ashina Håkan , Al-Khazali Haidar M. , Rose Kathrine , Christensen Rune Häckert , Amin Faisal Mohammad , Ashina Messoud
Published: February 2024

Background

About one-third of persons with migraine experience transient neurologic symptoms, referred to as aura. Despite its widespread prevalence, comprehensive clinical descriptions of migraine with aura remain sparse. Therefore, we aimed to provide an in-depth phenotypic analysis of aura symptoms and characteristics in a cross-sectional study of a large sample of adults diagnosed with migraine with aura.

Methods

Data were extracted from the baseline characteristics of participants in the Registry for Migraine (REFORM) study – a single-center, prospective, longitudinal cohort study. Participants were adults diagnosed with migraine aura, reporting ≥ 4 monthly migraine days in the preceding 3 months. Trained personnel conducted in-person semi-structured interviews, capturing details on the nature, duration, localization, and progression of individual aura symptoms.

Results

Of the 227 enrolled participants with migraine with aura, the mean age was 41.1 years, with a predominant female representation (n = 205 [90.3%]). Visual aura was present in 215 (94.7%) participants, somatosensory aura in 81 (35.7%), and speech and/or language aura in 31 (13.7%). A single type of aura was observed in 148 (65.2%) participants, whilst 79 (34.8%) reported multiple aura types. Most participants (n = 220 [96.9%]) described their aura symptoms as positive or gradually spreading. Headache in relation to aura was noted by 218 (96.0%) participants, with 177 (80.8%) stating that the onset of aura symptoms preceded the onset of headache.

Conclusions

This study offers a detailed clinical depiction of persons with migraine with aura, who were predominantly enrolled from a tertiary care unit. The findings highlight potential gaps in the available literature on migraine with aura and should bolster clinicians’ acumen in diagnosing migraine with aura in clinical settings.
IgG4-related retroperitoneal fibrosis mimicking renal pelvis tumor: a case report and literature review
Authors: Gokhan Sahin , Mehmet Dundar , Taskin Senturk
Published: February 2024

Background

Retroperitoneal fibrosis (RPF) is a rare disease characterized by the development of a fibroinflammatory mass in the retroperitoneum. Immunoglobulin-G4 related RPF was suggested as a secondary form of RPF and thought to be part of the spectrum of Immunoglobulin-G4 related diseases (IgG4-RD). Patients often present to the clinic because of flank pain. Ranging from mild to end-stage renal failure can be observed. The main purpose of treatment is to preserve renal function. As it is a rare condition, there is no definite treatment strategy. We report a case of 39-year-old man with left flank pain and diagnosis of IgG4-related RPF mimicking a renal pelvis tumor.

Case presentation

A 39-year-old male patient presented with left flank pain. MRI suggested solid retroperitoneal mass associated with hydronephrosis in the left kidney collecting system. Upon identifying the retroperitoneal origin of the mass during nephroureterectomy, the procedure was concluded following the acquisition of frozen section and routine pathological samples from the lesion. In the histopathological examination, inflammatory cells were observed and specific immunohistochemistry for IgG-4 was detected focally positive. Following the placement of a DJ stent, immunosuppressive therapy was initiated with Prednol and Azathioprine. After a one-year follow-up period, during which the patient received immunosuppressive treatment and underwent tri-monthly DJ stent replacements, the DJ stent was subsequently removed, revealing complete regression of hydronephrosis.

Conclusions

With the correct diagnosis and treatment of IgG4-related RPF, it is possible to prevent irreversible complications of the disease. Because it is a rare disease, case reports in the literature will be useful for treatment.
Trehalose 6-phosphate synthase gene rdtps1 contributes to thermal acclimation in Rhyzopertha dominica
Authors: Xue Dingrong , Yang Yan , Fang Liwei , Wang Shibo , Wu Yi
Published: February 2024

Background

The lesser grain borer (Rhyzopertha dominica), a worldwide primary pest of stored grain, causes serious economic losses and threatens stored food safety. R. dominica can respond to changes in temperature, especially the adaptability to heat. In this study, transcriptome analysis of R. dominica exposed to different temperatures was performed to elucidate differences in gene expression and the underling molecular mechanism.

Results

Isoform-sequencing generated 17,721,200 raw reads and yielded 20,416 full-length transcripts. A total of 18,880 (92.48%) transcripts were annotated. We extracted RNA from R. dominica reared at 5 °C (cold stress), 15 °C (cold stress), 27 °C (ambient temperature) and 40 °C (heat stress) for RNA-seq. Compared to those of control insects reared at 27 °C, 119, 342, and 875 differentially expressed genes (DEGs) were identified at 5 °C, 15 °C, and 40 °C, respectively. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis revealed that pathways associated with “fatty acid metabolism”, “fatty acid biosynthesis”, “AMPK signaling pathway”, “neuroactive ligand receptor interaction”, and “longevity regulating pathway-multiple species” were significantly enriched. The functional annotation revealed that the genes encoding heat shock proteins (HSPs), fatty acid synthase (FAS), phospholipases (PLA), trehalose transporter (TPST), trehalose 6-phosphate synthase (TPS), and vitellogenin (Vg) were most likely involved in temperature regulation, which was also validated by RT-qPCR. Seven candidate genes (rdhsp1, rdfas1, rdpla1, rdtpst1, rdtps1, rdvg1, and rdP450) were silenced in the RNA interference (RNAi) assay. RNAi of each candidate gene suggested that inhibiting rdtps1 expression significantly decreased the trehalose level and survival rate of R. dominica at 40 °C.

Conclusions

These results indicated that trehalose contributes to the high temperature resistance of R. dominica. Our study elucidates the molecular mechanisms underlying heat tolerance and provides a potential target for the pest management in R. dominica.
Leaf rust (Puccinia recondita f. sp. secalis) triggers substantial changes in rye (Secale cereale L.) at the transcriptome and metabolome levels
Authors: Krępski T. , Piasecka A. , Święcicka M. , Kańczurzewska M. , Sawikowska A. , Dmochowska-Boguta M. , Rakoczy-Trojanowska M. , Matuszkiewicz M.
Published: February 2024

Background

Rye (Secale cereale L.) is a cereal crop highly tolerant to environmental stresses, including abiotic and biotic stresses (e.g., fungal diseases). Among these fungal diseases, leaf rust (LR) is a major threat to rye production. Despite extensive research, the genetic basis of the rye immune response to LR remains unclear.

Results

An RNA-seq analysis was conducted to examine the immune response of three unrelated rye inbred lines (D33, D39, and L318) infected with compatible and incompatible Puccinia recondita f. sp. secalis (Prs) isolates. In total, 877 unique differentially expressed genes (DEGs) were identified at 20 and 36 h post-treatment (hpt). Most of the DEGs were up-regulated. Two lines (D39 and L318) had more up-regulated genes than down-regulated genes, whereas the opposite trend was observed for line D33. The functional classification of the DEGs helped identify the largest gene groups regulated by LR. Notably, these groups included several DEGs encoding cytochrome P450, receptor-like kinases, methylesterases, pathogenesis-related protein-1, xyloglucan endotransglucosylases/hydrolases, and peroxidases.

The metabolomic response was highly conserved among the genotypes, with line D33 displaying the most genotype-specific changes in secondary metabolites. The effect of pathogen compatibility on metabolomic changes was less than the effects of the time-points and genotypes. Accordingly, the secondary metabolome of rye is altered by the recognition of the pathogen rather than by a successful infection. The results of the enrichment analysis of the DEGs and differentially accumulated metabolites (DAMs) reflected the involvement of phenylpropanoid and diterpenoid biosynthesis as well as thiamine metabolism in the rye immune response.

Conclusion

Our work provides novel insights into the genetic and metabolic responses of rye to LR. Numerous immune response-related DEGs and DAMs were identified, thereby clarifying the mechanisms underlying the rye response to compatible and incompatible Prs isolates during the early stages of LR development. The integration of transcriptomic and metabolomic analyses elucidated the contributions of phenylpropanoid biosynthesis and flavonoid pathways to the rye immune response to Prs. This combined analysis of omics data provides valuable insights relevant for future research conducted to enhance rye resistance to LR.
Quality of care in patients with hypertension: a retrospective cohort study of primary care routine data in Germany
Authors: Strumann Christoph , Engler Nicola J. , von Meissner Wolfgang C. G. , Blickle Paul-Georg , Steinhäuser Jost
Published: February 2024

Background

Hypertension is a leading cause of morbidity and mortality if not properly managed. Primary care has a major impact on these outcomes if its strengths, such as continuity of care, are deployed wisely. The analysis aimed to evaluate the quality of care for newly diagnosed hypertension in routine primary care data.

Methods

In the retrospective cohort study, routine data (from 2016 to 2022) from eight primary care practices in Germany were exported in anonymized form directly from the electronic health record (EHR) systems and processed for this analysis. The analysis focused on five established quality indicators for the care of patients who have been recently diagnosed with hypertension.

Results

A total of 30,691 patients were treated in the participating practices, 2,507 of whom have recently been diagnosed with hypertension. Prior to the pandemic outbreak, 19% of hypertensive patients had blood pressure above 140/90 mmHg and 68% received drug therapy (n = 1,372). After the pandemic outbreak, the proportion of patients with measured blood pressure increased from 63 to 87%, while the other four indicators remained relatively stable. Up to 80% of the total variation of the quality indicators could be explained by individual practices.

Conclusion

For the majority of patients, diagnostic procedures are not used to the extent recommended by guidelines. The analysis showed that quality indicators for outpatient care could be mapped onto the basis of routine data. The results could easily be reported to the practices in order to optimize the quality of care.
Patient characteristics and reasons for discontinuation in a cardiovascular risk management programme in The Netherlands
Authors: Smits Geert H.J.M. , van Doorn Sander , Bots Michiel L. , Hollander Monika
Published: February 2024

Background

Since 2010, an increasing number of patients have participated in a nurse-led integrated cardiovascular risk management programme in the Netherlands. Because it is important to understand which patients discontinue and why, when evaluating the effectiveness of the care programme, the aim was to identify the reasons for discontinuation.

Methods

Electronic health records of 3997 patients enrolled in a nurse-led integrated cardiovascular risk management programme that started on April 1st, 2010, were manually scrutinized for reasons for discontinuation between April 1st, 2010, and April 1st, 2018. In addition to death and moving to a diabetes care programme, we describe 7 different reasons why patients discontinued the programme and compared the patient characteristics of those who discontinued the programme without specific reasons with those who remained in the care programme for 8 years.

Results

Between April 1st, 2010, and April 1st, 2018, 1,190 participants (29.8%) discontinued the CVRM care programme, of whom 271 participants died (6.8%) and 195 were transferred to a diabetes care programme (4.9%). The remaining 724 patients (18.1%) participated 5 years before discontinuation. Of these, 67 (9.3%) had a previous cardiovascular event at the start of the programme. In 355 patients, a specific reason for discontinuation was not found. At baseline, these patients less frequently had a history of CVD than those who continued the programme for 8 years (1.7 vs. 22.6%), were younger (62 vs. 67 years), had less registered cardiovascular comorbidity (atrial fibrillation: 1.1 vs. 7.2%; congestive heart failure 0.3 vs. 1.2%; chronic kidney disease 0.0 vs. 4.5%), were more often smokers (13.0% vs. 4.3%) and took blood pressure- and lipid-lowering drugs twice as often.

Conclusions

In our study we observed that participants who discontinued the nurse-led integrated CVRM care programme between 2010 and 2018 without specific reason or on request were younger, without previous CVD, had less cardiovascular comorbidity and were better adjusted to medication. Exploring the patients’ reasons for discontinuation can contribute to an individualized approach to prevent or reduce discontinuation.
Myelin oligodendrocyte glycoprotein (MOG) associated optic neuritis in a patient with idiopathic intracranial hypertension (IIH) and compressive optic neuropathy case report
Authors: Sorensen Ryan D. , Vogt Ashtyn , Laylani Noor , Pakravan Mohammad , Lee Andrew G.
Published: February 2024

Background

Myelin oligodendrocyte glycoprotein-associated disease (MOGAD) has a wide phenotypic expression and should be considered in a differential diagnosis of patients with optic disc edema and increased intracranial pressure because MOGAD can mimic IIH and compressive optic neuropathy.

Case presentation

A 53-year-old woman with a history of presumed idiopathic intracranial hypertension (“IIH”) presented with new headache and visual loss. She had a BMI of 35.44 kg/m2 and a past medical history significant for depression, hepatitis C, hyperlipidemia, and uterine cancer post-hysterectomy. She had undergone multiple lumboperitoneal shunts for presumed IIH and had a prior pituitary adenoma resection. Her visual acuity was no light perception OD and counting fingers OS. After neuro-ophthalmic consultation, a repeat cranial MRI showed symmetric thin peripheral optic nerve sheath enhancement of the intra-orbital optic nerves OU. Serum MOG antibody was positive at 1:100 and she was treated with intravenous steroids followed by plasma exchange and rituximab.

Conclusions

This case highlights the importance of considering MOGAD in the differential diagnosis of optic neuropathy. Although likely multifactorial, we believe that the lack of improvement in our case from presumed IIH and despite adequate neurosurgical decompression of a pituitary adenoma with compression of the optic apparatus reflected underlying unrecognized MOGAD. Clinicians should consider repeat imaging of the orbit (in addition to the head) in cases of atypical IIH or compressive optic neuropathy especially when the clinical course or response to therapy is poor or progressive.
Evaluation of possible associated factors for early childhood caries: are preterm birth and birth weight related?
Authors: Selen Merve Bilmez , Demir Pınar , Inceoglu Feyza
Published: February 2024

Background

This study aimed to evaluate the oral and dental health of preschool children aged 12–71 months living in the Eastern Anatolia Region of Turkey, and to examine the effects of low birth weight (LBW) and preterm, early term and term birth on dental caries.

Methods

475 participants were included in the study. Intraoral examinations were performed and evaluated for the presence of early childhood caries (ECC). These values ​​are; Relationships such as age, gender, birth weight, week of birth, tooth brushing frequency, cariogenic nutrition, and parental education levels were examined. The obtained data were analyzed statistically (chi-square, t-test, artificial neural network (ANN)).

Results

Of the 475 participants, whose parents agreed to fill out the questionnaire, 250 were female and 225 were male. While the mean age was 49.78 ± 14.78 months for those with ECC, it was 38.93 ± 17.96 months for those without. Higher duration of breastfeeding (p = 0.04), education level of parents (p = 0.001), lower socioeconomic level (p = 0.001), and lower brushing frequency (p = 0.001) were also found to be significantly associated with ECC. ECC was seen in 90% of 77 children with a history of preterm birth. In LBW, this rate was 83%. According to the ANN result, in preterm birth; 12.9% affected ECC by LBW.

Conclusion

According to the results of our study, both LBW and preterm delivery were found to be associated with ECC and S-ECC (severe early childhood caries). An additional study on parents of preterm/LBW infants would be beneficial. In the early period, regular dental examination, implementation of preventive and preventive treatments, and nutrition education to parents can make a significant difference in the prevention of ECC.
Green-synthesized silver nanoparticles from Zingiber officinale extract: antioxidant potential, biocompatibility, anti-LOX properties, and in silico analysis
Authors: Ongtanasup Tassanee , Kamdenlek Patipat , Manaspon Chawan , Eawsakul Komgrit
Published: February 2024

Introduction

Zingiber officinale extract has emerged as a compelling candidate for green synthesis of nanoparticles, offering diverse applications across medicine, cosmetics, and nutrition. This study delves into the investigation of in vitro toxicity and explores the biomedical utility of green-synthesized silver nanoparticles derived from ginger extract (GE-AgNPs).

Methods

We employed established protocols to evaluate in vitro aspects such as antioxidant capacity, anti-inflammatory potential, and biocompatibility of GE-AgNPs. Additionally, molecular docking was employed to assess their anti-lipoxygenase (anti-LOX) activity.

Results

Our findings highlight that the extraction of ginger extract at a pH of 6, utilizing a cosolvent blend of ethanol and ethyl acetate in a 1:1 ratio, yields heightened antioxidant capacity attributed to its rich phenolic and flavonoid content. In the context of silver nanoparticle synthesis, pH 6 extraction yields the highest quantity of nanoparticles, characterized by an average size of 32.64 ± 1.65 nm. Of particular significance, GE-AgNPs (at pH 6) demonstrated remarkable efficacy in scavenging free radicals, as evidenced by an IC50 value of 6.83 ± 0.47 µg/mL. The results from the anti-LOX experiment indicate that GE-AgNPs, at a concentration of 10 µg/mL, can inhibit LOX activity by 25%, outperforming ginger extract which inhibits LOX by 17–18%. Notably, clionasterol exhibited higher binding energy and enhanced stability (-8.9 kcal/mol) compared to nordihydroguaiaretic acid. Furthermore, a cell viability study confirmed the safety of GE-AgNPs at a concentration of 17.52 ± 7.00 µg/mL against the L929 cell line.

Conclusion

These comprehensive findings underscore the significant biomedical advantages of GE-AgNPs and emphasize their potential incorporation into cosmetic products at a maximum concentration of 10 µg/mL.