bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanical Strength and Surface Analysis of a Composite Made from Recycled Carbon Fibre Obtained via the Pyrolysis Process for Reuse in the Manufacture of New Composites
Authors: Sales-Contini Rita C. M. , Costa Hugo M. S. , Bernardi Heide H. , Menezes William M. M. , Silva Francisco J. G.
Published: January 2024

This work aims to obtain recycled carbon fibre and develop an application for this new material. The carbon fibres were obtained by recycling aerospace prepreg waste via the pyrolysis process. The recycled fibres were combined with an Araldite LH5052/Aradur LY5053 epoxy resin/hardener system using manual lay-up and vacuum bagging processes. For comparison, the same resin/hardener system was used to produce a composite using commercial carbon fibre. The recycled and commercial composites were subjected to flexural, tensile and Mode I testing. Fracture aspects were analysed via scanning electron microscopy (SEM). The pyrolysis process did not affect the fibre surface as no degradation was observed. The fracture aspect showed a mixture of failure in the recycled composite laminate and interlaminar/translaminar failure near the surface of the commercial composite caused by flexural stress. Flexural and tensile tests showed a loss of mechanical strength due to the recycling process, but the tensile values were twice as high. The sand ladder platform was the project chosen for the development of a product made with recycled carbon fibres. The product was manufactured using the same manufacturing process as the specimens and tested with a 1243 kg car. The method chosen to design, manufacture and test the prototype sand ladder platform made of recycled carbon fibre was appropriate and gave satisfactory results in terms of high mechanical strength to bending and ease of use.
Influence of Silane Coupling Agent and Anionic Dispersant on the Dispersion Effect of Silicon Carbide Particles
Authors: Zheng Zheng , Li Min , Zhang Wenxiao , Zhang Xuhui , Liu Jiaxiang , Yang Tianyu
Published: January 2024

Silicon carbide (SiC), as a widely used material, has great properties. To improve the flowability of ultrafine silicon carbide slurry, this study used sodium humate, tetramethylammonium hydroxide (TMAH), and N-(β-monoaminoethyl)-γ-aminopropyltrimethyl(ethoxysilane) (KH792) to modify the ultrafine silicon carbide powder produced by Qingzhou Micro Powder Company. The effects of different modifiers on improving the flowability of ultrafine silicon carbide slurry were investigated by means of viscosity tests, sedimentation experiments, and SEM observations. Their modification mechanisms were investigated by means of zeta potential tests, XPS tests, and so on. In this paper, the initial modification of SiC was carried out with KH792, followed by the secondary modification with anionic and cationic modifiers (tetramethylammonium hydroxide and sodium humate), and the optimal modification conditions were investigated by means of a viscosity test, which showed that the lowest viscosity of the modified SiC reached 0.076 Pa·s and that the absolute maximum value of the zeta potential increased from 47.5 at the time of no modification to 63.7 (maximum values) at the time of modification. This means it has an improved surface charge, which improves dispersion. The adsorption results of the modifier on the silicon carbide surface were also demonstrated by the XPS test results.
A Superparaelectric State in Relaxor Ferroelectric (Sr,Bi)TiO3-Bi(Mg,Ti)O3-Modified BaTiO3 Ceramics to Achieve High Energy Storage Performance
Authors: Yoo Il-Ryeol , Choi Seong-Hui , Park Je-Yeon , Kim Min-Seok , Yadav Arun Kumar , Cho Kyung-Hoon
Published: January 2024

Dielectric ceramic capacitors are highly regarded for their rapid charge–discharge, high power density, and cyclability in various advanced applications. However, their relatively low energy storage density has prompted intensive research aiming at developing materials with a higher energy density. To enhance energy storage properties, research has focused on modifying ferroelectric materials to induce relaxor ferroelectricity. The present study aims to induce a superparaelectric (SPE) state in relaxor ferroelectrics near room temperature by altering BaTiO3 ferroelectric ceramics using the (Sr,Bi)TiO3-Bi(Mg0.5Ti0.5)O3 system ((1−x)BT-x(SBT-BMT)). X-ray diffraction and Raman spectroscopy analysis demonstrated a shift in the crystal structure from tetragonal to cubic with an increasing x content. Notably, the compositions (except x = 0.1) satisfied the criteria for the SPE state manifestation near room temperature. The x = 0.2 specimen displayed characteristics at the boundary between the relaxor ferroelectric and SPE phases, while x ≥ 0.3 specimens exhibited increased SPE state fractions. Despite reduced maximum polarization, x ≥ 0.3 specimens showcased impressive energy storage capabilities, attributed to the enhanced SPE state, especially for x = 0.3, with impressive characteristics: a recoverable energy density (Wrec) of ~1.12 J/cm3 and efficiency (η) of ~94% at 170 kV/cm applied field. The good stability after the charge–discharge cycles reinforces the significance of the SPE phase in augmenting energy storage in relaxor ferroelectric materials, suggesting potential applications in high-energy density storage devices.
Elastomer-Based Sealing O-Rings and Their Compatibility with Methanol, Ethanol, and Hydrotreated Vegetable Oil for Fueling Internal Combustion Engines
Authors: Müller Miroslav , Mishra Rajesh Kumar , Šleger Vladimir , Pexa Martin , Čedík Jakub
Published: January 2024

Green methanol, ethanol, and diesel-based hydrotreated vegetable oils are some of the renewable liquid fuels that show satisfactory performance in diesel engines. A notable advantage of these fuels is that they are renewable and do not require significant modifications in the existing engines for successful operation. Suitable fuel systems, especially their material compatibility, remain unresolved, and therefore, it is a weak link in their large-scale adaptation. Elastomer-based sealing O-rings lose their mechanical properties after a short exposure time to these fuels, adversely impacting their functionality. This research study evaluated the long-term material compatibility of different elastomer-based sealing materials by immersing the O-rings in these test fuels (hydrotreated vegetable oil, methanol, ethanol, and diesel) for different time intervals (i.e., up to 15 months). The material compatibility was assessed mainly by investigating these changes in various mechanical properties of these O-rings, namely tensile strength (ΔTs), elongation at break (ΔEb), Shore A hardness (ΔH), and mass (ΔM). The degradation of mechanical properties was studied and analyzed during the immersion interval from 0.9 to 15.2 months and compared with O-rings kept in a normal atmosphere. It was noted that individual fuels affect various mechanical properties significantly. In a short interval of 0.9 months (28 days), significant changes in the mechanical properties of the sealing O-rings were observed.
Parallel Pointing Systems Suitable for Robotic Total Stations: Selection, Dimensional Synthesis, and Accuracy Analysis
Authors: Simas Henrique , Di Gregorio Raffaele , Simoni Roberto , Gatti Marco
Published: January 2024

Robotic Total Stations (RTS) are fully automated theodolites with electronic distance measurement (EDM) that include a number of additional tools (e.g., camera, laser rangefinder, onboard computer, and tracking software, etc.) enabling them to work autonomously. The added tools make RTSs able to track mobile targets on civil structures thus opening to the use of RTSs in structural monitoring. Unfortunately, the available RTSs are able to track a target up to a motion rate of 3 Hz. Reducing mobile masses is a viable design strategy for extending this frequency border. Such a strategy is pursued in this study by proposing the use of parallel pointing systems (PPS) as basic mechanical architectures for RTSs. The literature on PPSs is reviewed and the applicable PPS architectures are selected. Successively, the selected architectures are sized according to RTSs’ functional requirements, and the positioning precision of the sized mechanisms is evaluated. The result of this study is that there are three PPS architectures suitable for RTSs, whose detailed comparison is also presented.
Fuzzy-Based Image Contrast Enhancement for Wind Turbine Detection: A Case Study Using Visual Geometry Group Model 19, Xception, and Support Vector Machines
Authors: Ward Zachary , Miller Jordan , Engel Jeremiah , Masoum Mohammad A. S. , Shekaramiz Mohammad , Seibi Abdennour
Published: January 2024

Traditionally, condition monitoring of wind turbines has been performed manually by certified rope teams. This method of inspection can be dangerous for the personnel involved, and the resulting downtime can be expensive. Wind turbine inspection can be performed using autonomous drones to achieve lower downtime, cost, and health risks. To enable autonomy, the field of drone path planning can be assisted by this research, namely machine learning that detects wind turbines present in aerial RGB images taken by the drone before performing the maneuvering for turbine inspection. For this task, the effectiveness of two deep learning architectures is evaluated in this paper both without and with a proposed fuzzy contrast enhancement (FCE) image preprocessing algorithm. Efforts are focused on two convolutional neural network (CNN) variants: VGG19 and Xception. A more traditional approach involving support vector machines (SVM) is also included to contrast a machine learning approach with our deep learning networks. The authors created a novel dataset of 4500 RGB images of size 210×210 to train and evaluate the performance of these networks on wind turbine detection. The dataset is captured in an environment mimicking that of a wind turbine farm, and consists of two classes of images: with and without a small-scale wind turbine (12V Primus Air Max) assembled at Utah Valley University. The images were used to describe in detail the analysis and implementation of the VGG19, Xception, and SVM algorithms using different optimization, model training, and hyperparameter tuning technologies. The performances of these three algorithms are compared in depth alongside those augmented using the proposed FCE image preprocessing technique.
Model Predictive Control of Humidity Deficit and Temperature in Winter Greenhouses: Subspace Weather-Based Modelling and Sampling Period Effects
Authors: Nakayama Shin , Takada Taku , Kimura Ryushi , Ohsumi Masato
Published: January 2024

Generally, windows in greenhouses are automatically opened and closed to regulate the internal temperature. However, because the air outside during the winter in Japan is dry, opening windows to reduce the temperature causes the humidity deficit to increase above 6 g/m3, thereby inhibiting plant growth. Therefore, in this study, we developed a model that considers the effects of weather and the sampling period using a subspace (N4SID) method based on environmental data from inside and outside a greenhouse during winter. By adopting a data-driven model, models for greenhouse temperature and humidity deficits can be constructed conveniently. First, four models incorporating weather conditions were constructed over a 28-day modelling period. Moreover, the average root mean square error values from 8:00 to 16:00 during the 10-day model evaluation period were examined. Subsequently, model predictive controllers were developed from the four models with sampling periods of 1, 2, 4, and 8 min, and their performances were compared over the model evaluation period. The model predictive controller with a sampling period of 4 min was the most energy-efficient, achieving control of the humidity deficit of up to at most 6 g/m3 (close to the target value of 4.5 g/m3) while maintaining the target temperature of 26 °C.
Identification of Parameters of Conservative Multispecies Lotka-Volterra System Based on Sampled Data
Authors: Semenov Aleksandr , Fradkov Alexander
Published: January 2024

In this paper, we propose a method for identifying the parameters of the multispecies Lotka-Volterra model based on sampled data. The conditions (nonhyperplanarity, recurrence) under which the “Stripe” algorithm achieves the identification goals are found. The relation between nonhyperplanar recurrent trajectories and the persistent excitation condition for systems of general form is studied.
A New Perspective on Moran’s Coefficient: Revisited
Authors: Yamada Hiroshi
Published: January 2024

Moran’s I (Moran’s coefficient) is one of the most prominent measures of spatial autocorrelation. It is well known that Moran’s I has a representation that is similar to a Fourier series and is therefore useful for characterizing spatial data. However, the representation needs to be modified. This paper contributes to the literature by showing the necessary modification and presenting some further results. In addition, we provide the required MATLAB/GNU Octave and R user-defined functions.
Visualizing Convergence Dynamics across Regions and States: h-Convergence
Authors: Leonida Leone
Published: January 2024

Researchers interested in studying whether convergence dynamics are in place among regions within the same country have adopted both statistical tools and empirical frameworks developed when studying convergence across different economies. We show that this approach is risky, because when an analysis is conducted at the regional level, the absolute and club convergence processes are more likely to co-exist than in the case of world economies. We propose an empirical approach where the two hypotheses are not taken as competing. Our procedure uncovers periods of convergence and periods of divergence for the three samples we studied: Italy observed at both the regional and provincial levels; EU regions; and world economies. We find a process of absolute convergence for Italian regions from 1951 to 1999, and that their convergence process ends in 1971 after a period which we define as clustering convergence. We also find a process of convergence across European regions from 1977 to 1993; that ends in 1985 in favor of a process of clustering and divergence. Finally, our procedure uncovers a process of absolute convergence from 1964 to 1975 and divergence from 1975 to 1999 in the case of world economies.
Chaotic Binarization Schemes for Solving Combinatorial Optimization Problems Using Continuous Metaheuristics
Authors: Cisternas-Caneo Felipe , Crawford Broderick , Soto Ricardo , Giachetti Giovanni , Paz Álex , Peña Fritz Alvaro
Published: January 2024

Chaotic maps are sources of randomness formed by a set of rules and chaotic variables. They have been incorporated into metaheuristics because they improve the balance of exploration and exploitation, and with this, they allow one to obtain better results. In the present work, chaotic maps are used to modify the behavior of the binarization rules that allow continuous metaheuristics to solve binary combinatorial optimization problems. In particular, seven different chaotic maps, three different binarization rules, and three continuous metaheuristics are used, which are the Sine Cosine Algorithm, Grey Wolf Optimizer, and Whale Optimization Algorithm. A classic combinatorial optimization problem is solved: the 0-1 Knapsack Problem. Experimental results indicate that chaotic maps have an impact on the binarization rule, leading to better results. Specifically, experiments incorporating the standard binarization rule and the complement binarization rule performed better than experiments incorporating the elitist binarization rule. The experiment with the best results was STD_TENT, which uses the standard binarization rule and the tent chaotic map.
Effect of pH on the Structure, Functional Properties and Rheological Properties of Collagen from Greenfin Horse-Faced Filefish (Thamnaconus septentrionalis) Skin
Authors: Wu Kunyuan , Li Yushuang , Chen Junde
Published: January 2024

Collagen is an important biopolymer widely used in food, cosmetics and biomedical applications. Understanding the effect of pH on the structure and properties of collagen is beneficial for its further processing and exploitation. In this study, greenfin horse-faced filefish skin collagen (GHSC) was prepared and identified as a type I collagen. We systematically investigated the effect of pH on the structural, functional and rheological properties of GHSC. Scanning electron microscopy showed that the collagen morphology changed from an ordered stacked sheet structure to a rough silk-like structure as pH increased. Gaussian-fitted Fourier infrared spectroscopy results of the collagen revealed that it unfolded with increasing pH. Moreover, the ordered structure was reduced, and random coils became the dominant conformation. Its β-sheet and random coil contents increased from 18.43 ± 0.08 and 33.62 ± 0.17 to 19.72 ± 0.02 and 39.53 ± 1.03%, respectively, with increasing pH. α-helices and β-turns decreased from 35.00 ± 0.26 and 12.95 ± 0.01 to 29.39 ± 0.92 and 11.36 ± 0.10%, respectively. The increase in β-sheets and random coils allowed the pI-treated collagen to exhibit maximum water contact angle. The emulsification and foaming properties decreased and then increased with increasing pH in a V-shape. The increased net surface charge and β-sheets in collagen benefited its emulsification and foaming properties. The rheological results showed that the protoprotein exhibited shear-thinning properties in all pH ranges. The collagen solutions showed liquid-like behaviour in low-pH (2, 4) solutions and solid-like behaviour in high-pH (6, 7.83 and 10) solutions. Moreover, the frequency-dependent properties of the storage modulus (G′) and loss modulus (G″) of the collagen solutions weakened with increasing pH. Collagen has considerable frequency-dependent properties of G′ and G″ at low pH (2, 4). Thus, the importance of collagen raw material preparation for subsequent processing was emphasised, which may provide new insights into applying collagen-based materials in food, biomaterials and tissue engineering.
Combined Area of Left and Right Atria May Outperform Atrial Volumes as a Predictor of Recurrences after Ablation in Patients with Persistent Atrial Fibrillation—A Pilot Study
Authors: Mărgulescu Andrei D. , Mas-Lladó Caterina , Prat-Gonzàlez Susanna , Perea Rosario Jesus , Borras Roger , Benito Eva , Alarcón Francisco , Guasch Eduard , Tolosana Jose María , Arbelo Elena , Sitges Marta , Brugada Josep , Mont Lluís
Published: January 2024

Background and Objectives: Left atrial (LA) remodelling and dilatation predicts atrial fibrillation (AF) recurrences after catheter ablation. However, whether right atrial (RA) remodelling and dilatation predicts AF recurrences after ablation has not been fully evaluated. Materials and Methods: This is an observational study of 85 consecutive patients (aged 57 ± 9 years; 70 [82%] men) who underwent cardiac magnetic resonance before first catheter ablation for AF (40 [47.1%] persistent AF). Four-chamber cine-sequence was selected to measure LA and RA area, and ventricular end-systolic image phase to obtain atrial 3D volumes. The effect of different variables on event-free survival was investigated using the Cox proportional hazards model. Results: In patients with persistent AF, combined LA and RA area indexed to body surface area (AILA + RA) predicted AF recurrences (HR = 1.08, 95% CI 1.00–1.17, p = 0.048). An AILA + RA cut-off value of 26.7 cm2/m2 had 72% sensitivity and 73% specificity for predicting recurrences in patients with persistent AF. In this group, 65% of patients with AILA + RA > 26.7 cm2/m2 experienced AF recurrence within 2 years of follow-up (median follow-up 11 months), compared to 25% of patients with AILA + RA ≤ 26.7 cm2/m2 (HR 4.28, 95% CI 1.50–12.22; p = 0.007). Indices of LA and RA dilatation did not predict AF recurrences in patients with paroxysmal AF. Atrial 3D volumes did not predict AF recurrences after ablation. Conclusions: In this pilot study, the simple measurement of AILA + RA may predict recurrences after ablation of persistent AF, and may outperform measurements of atrial volumes. In paroxysmal AF, atrial dilatation did not predict recurrences. Further studies on the role of RA and LA remodelling are needed.
Reduced-Dose or Discontinuation of Bevacizumab Might Be Considered after Variceal Bleeding in Patients with Hepatocellular Carcinoma Receiving Atezolizumab/Bevacizumab: Case Reports
Authors: Yeom Kyeong-Min , Song Young-Gi , Yoo Jeong-Ju , Kim Sang Gyune , Kim Young Seok
Published: January 2024

Background and Objectives: Variceal bleeding (VB) is the most concerning condition that is difficult to treat after atezolizumab/bevacizumab in patients with advanced hepatocellular carcinoma (HCC). Materials and Methods: We would like to introduce the cases of two patients who underwent bevacizumab reduction or discontinuation when VB occurred after atezolizumab/bevacizumab. Results: VB occurred in two patients who showed good tumor response after atezolizumab/bevacizumab treatment, and all VBs were successfully treated with endoscopic variceal ligations. In the first patient, VB did not occur as the tumor response decreased after a 50% reduction in bevacizumab. In the second patient, VB occurred again after a 50% bevacizumab reduction, so bevacizumab was discontinued and treatment with atezolizumab alone has been successfully maintained. Conclusions: Accordingly, we would like to suggest that considering bevacizumab dose reduction instead of changing to tyrosine kinase inhibitor may be a good clinical choice in atezolizumab/bevacizumab patients who develop VB.
Metabolomic Changes in Rat Serum after Chronic Exposure to Glyphosate-Based Herbicide
Authors: Daramola Oluwatosin , Gutierrez Reyes Cristian D. , Chávez-Reyes Jesús , Marichal-Cancino Bruno A. , Nwaiwu Judith , Onigbinde Sherifdeen , Adeniyi Moyinoluwa , Solomon Joy , Bhuiyan Md Mostofa Al Amin , Mechref Yehia
Published: January 2024

Glyphosate-based herbicides (GBHs) have gained extensive popularity in recent decades. For many years, glyphosate has been regarded as harmless or minimally toxic to mammals due to the absence of its primary target, the shikimic acid pathway in humans. Nonetheless, mounting evidence suggests that glyphosate may cause adverse health effects in humans via other mechanisms. In this study, we described the metabolomic changes in the serum of experimental rats exposed to chronic GBH using the highly sensitive LC-MS/MS technique. We investigated the possible relationship between chronic exposure to GBH and neurological disorders. Our findings suggest that chronic exposure to GBH can alter spatial learning memory and the expression of some important metabolites that are linked to neurophysiological disorders in young rats, with the female rats showing higher susceptibility compared to the males. This indicates that female rats are more likely to show early symptoms of the disorder on exposure to chronic GBH compared to male rats. We observed that four important metabolites (paraxanthine, epinephrine, L-(+)-arginine, and D-arginine) showed significant changes and involvement in neurological changes as suggested by ingenuity pathway analysis. In conclusion, our results indicate that chronic exposure to GBH can increase the risk of developing neurological disorders.
High-Pressure Hydrogenation: A Path to Efficient Methane Production from CO2
Authors: Gothe Maitê L. , Figueredo Adolfo L. , Borges Laís R. , Ramos Ruben , Peixoto Andreia F. , Vidinha Pedro
Published: January 2024

Methane has a rather relevant role in the “Power-to-Gas” concept, which is central in the current paradigm of climate change and renewable energies. Methane, the main component of natural gas, can be produced by catalytic hydrogenation reactions, particularly of CO2. A very effective catalyst in this reaction, hydrotalcite-derived nickel nanoparticles supported on alumina, Ni/Al2O3-HTC, can be employed in a high-pressure flow reactor to convert CO2 and H2 into CH4 at 100% selectivity and 84% conversion, whereas at atmospheric pressure, methane can be obtained with up to 90% selectivity. The high-pressure aspect also allows fast-paced production—over 5 m3·h−1·kgcat−1 of CH4 can be generated.
A 2.8 kV Breakdown Voltage α-Ga2O3 MOSFET with Hybrid Schottky Drain Contact
Authors: Oh Seung Yoon , Jeong Yeong Je , Kang Inho , Park Ji-Hyeon , Yeom Min Jae , Jeon Dae-Woo , Yoo Geonwook
Published: January 2024

Among various polymorphic phases of gallium oxide (Ga2O3), α-phase Ga2O3 has clear advantages such as its heteroepitaxial growth as well as wide bandgap, which is promising for use in power devices. In this work, we demonstrate α-Ga2O3 MOSFETs with hybrid Schottky drain (HSD) contact, comprising both Ohmic and Schottky electrode regions. In comparison with conventional Ohmic drain (OD) contact, a lower on-resistance (Ron) of 2.1 kΩ mm is achieved for variable channel lengths. Physics-based TCAD simulation is performed to validate the turn-on characteristics of the Schottky electrode region and the improved Ron. Electric-field analysis in the off-state is conducted for both the OD and HSD devices. Furthermore, a record breakdown voltage (BV) of 2.8 kV is achieved, which is superior to the 1.7 kV of the compared OD device. Our results show that the proposed HSD contact with a further optimized design can be a promising drain electrode scheme for α-Ga2O3 power MOSFETs.
Modeling for High-Frequency Spurious Responses in Incredible High-Performance Surface Acoustic Wave Devices
Authors: Jiang Guanzhen , Shuai Yao , Wei Zijie , Yao Jialin , Luo Wenbo , Pan Xinqiang , Wu Chuangui , Zhang Wanli
Published: January 2024

To ensure that surface acoustic wave (SAW) filters fulfill the requirements of Carrier Aggregation (CA) applications, the development of modeling tools that can forecast and simulate high-frequency spurious responses has been necessary. This paper presents an advanced methodology for extending the coupling-of-modes (COM) model to obtain precise modeling of the high-frequency spurious responses of incredible high-performance surface acoustic wave (I.H.P. SAW) devices. The extended COM (ECOM) model is derived by modifying the conventional COM model and extending it accordingly. The parameters used in this model are determined through numerical fitting. For validation, firstly, the ECOM model is applied to a one-port synchronous I.H.P. SAW resonator, and the simulation and measurement results match. Then, the structural parameters of the ECOM model are varied, and the accuracy of the model after the structural parameters are varied is verified. It is demonstrated that this model can be applied to the design work of SAW filters. Finally, the ECOM model is applied to the design of the I.H.P. SAW filter based on a 42°YX-LiTaO3 (LT)/SiO2/AlN/Si structure. By using this method, the I.H.P. SAW filter’s high-frequency spurious response can be predicted more accurately.
Green Anisole as Antisolvent in Planar Triple-Cation Perovskite Solar Cells with Varying Cesium Concentrations
Authors: La Ferrara Vera , De Maria Antonella , Rametta Gabriella
Published: January 2024

The feasibility of replacing toxic chlorobenzene antisolvents with environmentally friendly anisole in the fabrication of planar triple-cation perovskite solar cells was explored here. The successful integration of anisole not only ensures comparable device performance but also contributes to the development of more sustainable and green fabrication processes for next-generation photovoltaic technologies. Nevertheless, to ensure the possibility of achieving well-functioning unencapsulated devices whose working operation depends on outdoor atmospheric conditions, we found that adjusting the cesium concentrations in the perovskite layers enabled the electrical characterization of efficient devices even under high relative humidity conditions (more than 40%). We found that 10% of CsI in the precursor solution will make devices with low hysteresis indexes and sustained performance stability over a 90-day period both with cholorobenzene and anisole antisolvent. These results further confirm that green anisole can replace chlorobenzene as an antisolvent.
Photochromic Responses and Stability of Functional Inks Applied on Sustainable Packaging Materials
Authors: Mahović Poljaček Sanja , Strižić Jakovljević Maja , Tomašegović Tamara
Published: January 2024

Photochromism refers to a reversible colour change induced by the irradiation of photochromic materials with ultraviolet (UV) or visible light that reverts to the original colour after the light source is removed. This effect arises from chemical transformations between two isomers with different absorption spectra, involving processes like proton transfer, chemical-bond formation, and isomerisation. These photochromic inks, appearing as crystalline powders with micro-sized particles, require dissolution in a suitable matrix to achieve the colour change. Photochromic inks are used in security, as functional coatings for paper and packaging, in the fabric industry, and in other ways. This study examines the influence of varying concentrations of micro-sized photochromic pigments and different ink-coating thicknesses on the photochromic effect on sustainable paperboard substrates. Artificial ageing was performed to assess the photochromic response and lightfastness in relation to pigment concentration, ink-coating thickness, and the influence of the paperboard substrates. The results of this research could contribute to enhancing knowledge on employing photochromic inks for diverse packaging applications.
Real-Time TDM-Guided Optimal Joint PK/PD Target Attainment of Continuous Infusion Piperacillin–Tazobactam Monotherapy Is an Effective Carbapenem-Sparing Strategy for Treating Non-Severe ESBL-Producing Enterobacterales Secondary Bloodstream Infections: Findings from a Prospective Pilot Study
Authors: Gatti Milo , Bonazzetti Cecilia , Pascale Renato , Giannella Maddalena , Viale Pierluigi , Pea Federico
Published: January 2024

(1) Objectives: To assess the impact of optimal joint pharmacokinetic/pharmacodynamic (PK/PD) target attainment of continuous infusion (CI) piperacillin–tazobactam monotherapy on the microbiological outcome of documented ESBL-producing Enterobacterlaes secondary bloodstream infections (BSIs). (2) Methods: Patients hospitalized in the period January 2022–October 2023, having a documented secondary BSI caused by ESBL-producing Enterobacterales, and being eligible for definitive targeted CI piperacillin–tazobactam monotherapy according to specific pre-defined inclusion criteria (i.e., absence of septic shock at onset; favorable clinical evolution in the first 48 h after starting treatment; low–intermediate risk primary infection source) were prospectively enrolled. A real-time therapeutic drug monitoring (TDM)-guided expert clinical pharmacological advice (ECPA) program was adopted for optimizing (PK/PD) target attainment of CI piperacillin–tazobactam monotherapy. Steady-state plasma concentrations (Css) of both piperacillin and tazobactam were measured, and the free fractions (f) were calculated based on theoretical protein binding. The joint PK/PD target attainment was considered optimal whenever the piperacillin fCss/MIC ratio was >4 and the tazobactam fCss/target concentration (CT) ratio was >1 (quasi-optimal or suboptimal if only one or neither of the two thresholds were achieved, respectively). Univariate analysis was carried out for assessing variables potentially associated with failure in achieving the optimal joint PK/PD target of piperacillin–tazobactam and microbiological eradication. (3) Results: Overall, 35 patients (median age 79 years; male 51.4%) were prospectively included. Secondary BSIs resulted from urinary tract infections as a primary source in 77.2% of cases. The joint PK/PD target attainment was optimal in as many as 97.1% of patients (34/35). Microbiological eradication occurred in 91.4% of cases (32/35). Attaining the quasi-optimal/suboptimal joint PK/PD target of CI piperacillin–tazobactam showed a trend toward a higher risk of microbiological failure (33.3% vs. 0.0%; p = 0.08) (4) Conclusions: Real-time TDM-guided optimal joint PK/PD target attainment of CI piperacillin–tazobactam monotherapy may represent a valuable and effective carbapenem-sparing strategy when dealing with non-severe ESBL-producing Enterobacterales secondary BSIs.
Treatment of Microsporidium Nosema bombycis Spores with the New Antiseptic M250 Helps to Avoid Bacterial and Fungal Contamination of Infected Cultures without Affecting Parasite Polar Tube Extrusion
Authors: Senderskiy Igor V. , Dolgikh Viacheslav V. , Ismatullaeva Diloram A. , Mirzakhodjaev Bakhtiyar A. , Nikitina Anastasiia P. , Pankratov Danil L.
Published: January 2024

Microsporidia are a group of widespread eukaryotic spore-forming intracellular parasites of great economic and scientific importance. Since microsporidia cannot be cultured outside of a host cell, the search for new antimicrosporidian drugs requires an effective antiseptic to sterilize microsporidian spores to infect cell lines. Here, we show that a new polyhexamethylene guanidine derivative M250, which is active against fungi and bacteria at a concentration of 0.5–1 mg/L, is more than 1000 times less effective against spores of the microsporidium Nosema bombycis, a highly virulent pathogen of the silkworm Bombyx mori (LC50 is 0.173%). Treatment of N. bombycis spores that were isolated non-sterilely from silkworm caterpillars with 0.1% M250 solution does not reduce the rate of spore polar tube extrusion. However, it completely prevents contamination of the Sf-900 III cell culture medium by microorganisms in the presence of antibiotics. The addition of untreated spores to the medium results in contamination, whether antibiotics are present or not. Since 0.1% M250 does not affect spore discharging, this compound may be promising for preventing bacterial and fungal contamination of microsporidia-infected cell cultures.
The Impact and Effects of Host Immunogenetics on Infectious Disease Studies Using Non-Human Primates in Biomedical Research
Authors: Berry Neil , Mee Edward T. , Almond Neil , Rose Nicola J.
Published: January 2024

Understanding infectious disease pathogenesis and evaluating novel candidate treatment interventions for human use frequently requires prior or parallel analysis in animal model systems. While rodent species are frequently applied in such studies, there are situations where non-human primate (NHP) species are advantageous or required. These include studies of animals that are anatomically more akin to humans, where there is a need to interrogate the complexity of more advanced biological systems or simply reflect susceptibility to a specific infectious agent. The contribution of different arms of the immune response may be addressed in a variety of NHP species or subspecies in specific physiological compartments. Such studies provide insights into immune repertoires not always possible from human studies. However, genetic variation in outbred NHP models may confound, or significantly impact the outcome of a particular study. Thus, host factors need to be considered when undertaking such studies. Considerable knowledge of the impact of host immunogenetics on infection dynamics was elucidated from HIV/SIV research. NHP models are now important for studies of emerging infections. They have contributed to delineating the pathogenesis of SARS-CoV-2/COVID-19, which identified differences in outcomes attributable to the selected NHP host. Moreover, their use was crucial in evaluating the immunogenicity and efficacy of vaccines against COVID-19 and establishing putative correlates of vaccine protection. More broadly, neglected or highly pathogenic emerging or re-emergent viruses may be studied in selected NHPs. These studies characterise protective immune responses following infection or the administration of candidate immunogens which may be central to the accelerated licensing of new vaccines. Here, we review selected aspects of host immunogenetics, specifically MHC background and TRIM5 polymorphism as exemplars of adaptive and innate immunity, in commonly used Old and New World host species. Understanding this variation within and between NHP species will ensure that this valuable laboratory source is used most effectively to combat established and emerging virus infections and improve human health worldwide.
Antimicrobial and Other Pharmacological Properties of Ocimum basilicum, Lamiaceae
Authors: Zhakipbekov Kairat , Turgumbayeva Aknur , Akhelova Sholpan , Bekmuratova Kymbat , Blinova Olga , Utegenova Gulnara , Shertaeva Klara , Sadykov Nurlan , Tastambek Kuanysh , Saginbazarova Akzharkyn , Urazgaliyev Kenzhebek , Tulegenova Gulbanu , Zhalimova Zere , Karasova Zhanylsyn
Published: January 2024

Since ancient times, various scientists and doctors have utilized different herbs to heal diseases. Due to the rise in drug resistance and the negative effects of chemosynthetic drugs, researchers and the general public around the world have become more interested in medicinal herbs and plant metabolites/extracts. This is due to its non-toxicity and its several health benefits when used to treat diseases in clinical and medical settings. Ocimum basilicum is one such plant, possessing a wide range of bioactive phytochemicals including alkaloids, phenolics, flavonoids, tannins, saponins, reducing sugars, cardiac glycosides, steroids and glycosides, as well as complex pharmacological activities, including anti-inflammatory, antifungal, antibacterial, antioxidant, wound healing and antiviral properties. The results of many studies on Ocimum basilicum plant extracts are collected and presented in this review. The plant extracts have excellent potential to be used as medicinal raw materials, and exhibit an extensive variety of therapeutic capacities, including antibacterial, antioxidant, wound healing, anti-inflammatory, antifungal, and antiviral properties.
A Continuous-Wave EPR Investigation into the Photochemical Transformations of the Chromium(I) Carbonyl Complex [Cr(CO)4bis(diphenylphosphino)]+ and Reactivity with 1-hexene
Authors: Fioco David , Folli Andrea , Platts James , Chiesa Mario , Murphy Damien M.
Published: January 2024

Chromium complexes containing a bis(diphenylphosphino) ligand have attracted significant interest over many years due to their potential as active catalysts for ethylene oligomerisation when combined with suitable co-catalysts such as triethylaluminium (TEA) or methylaluminoxane (MAO). While there has been considerable attention devoted to the possible reaction intermediates and the nature of the Cr oxidation states involved, the potential UV photoactivity of the Cr(I) complexes has so far been overlooked. Therefore, to explore the photoinduced transformations of bis(diphenylphosphino) stabilized Cr(I) complexes, we used continuous-wave (CW) EPR to study the effects of UV radiation on a cationic [Cr(CO)4(dppp)]+[Al(OC(CF3)3)4]− complex (1), where dppp represents the 1,3 bis-(diphenylphosphino)propane ligand, Ph2P(C3H6)PPh2. Our preliminary investigations into the photochemistry of this complex revealed that [Cr(CO)4(dppp)]+ (1) can be readily photo-converted into an intermediate mer-[Cr(CO)3(κ1-dppp)(κ2-dppp)]+ complex (2) and eventually into a trans-[Cr(CO)2(dppp)2]+ complex (3) in solution at room temperature under UV-A light. Here, we show that the intermediate species (2) involved in this transformation can be identified by EPR at much lower temperature (140 K) and at a specific wavelength (highlighting the wavelength dependency of the reaction). In addition, small amounts of a ‘piano-stool’-type complex, namely [Cr(CO)2(dppp-η6-arene)]+ (4), can also be formed during the photoconversion of [Cr(CO)4(dppp)]+ using UV-A light. There was no evidence for the formation of the [Cr(L-bis-η6-arene)]+ complex (5) in these UV irradiation experiments. For the first time, we also evidence the formation of a 1-hexene coordinated [Cr(CO)3(dppp)(1-hexene)]+ complex (6) following UV irradiation of [Cr(CO)4(dppp)]+ in the presence of 1-hexene; this result demonstrates the unprecedented opportunity for exploiting light activation during Cr-driven olefin oligomerisation catalysis, instead of expensive, difficult-to-handle, and hazardous chemical activators.
Diterpenoids with Schistosomula-Killing and Anti-Fibrosis Activities In Vitro from the Leaves of Croton tiglium
Authors: Li Li , Zhao Biqing , Zheng Xiaoxiao , Liu Zhaohui , Zou Huan , Qin Li , Zhou Xiaojiang
Published: January 2024

The leaves of C. tiglium have been comprehensively researched for their structurally novel bioactive natural compounds, especially those with anti-schistosomiasis liver fibrosis activity, because ethyl acetate extract, which can be extracted from the leaves of C. tiglium, has good anti-schistosomiasis liver fibrosis effects. One new tigliane-type diterpene, 20-acetyl-13-O-(2-metyl)butyryl-phorbol (1), and nine known (2–10) analogues were isolated from the leaves of C. tiglium. Their structures were elucidated on the basis of spectroscopic analysis and ECD analysis. All diterpenoids had a stronger insecticidal effect on schistosomula, and compounds 2, 4, and 10 had good anti-liver-fibrosis effects. Furthermore, compared with the model group, compound 2 significantly downregulated the protein and mRNA expression of COL-I, COL-III, α-SMA, and TGF-β1 on TGF-β1-induced liver fibrosis in LX-2 cells. Meanwhile, compound 2 also regulated the expression of TGF-β/Smad-pathway-related proteins. The results suggest that diterpenoids from C. tiglium may serve as potential schistosomula-killing and anti-liver-fibrosis agents in the future.
Decoding Cosmetic Complexities: A Comprehensive Guide to Matrix Composition and Pretreatment Technology
Authors: Du Xiao-Nan , He Yu , Chen You-Wen , Liu Qian , Sun Lei , Sun Hui-Min , Wu Xian-Fu , Lu Yong
Published: January 2024

Despite advancements in analytical technologies, the complex nature of cosmetic matrices, coupled with the presence of diverse and trace unauthorized additives, hinders the application of these technologies in cosmetics analysis. This not only impedes effective regulation of cosmetics but also leads to the continual infiltration of illegal products into the market, posing serious health risks to consumers. The establishment of cosmetic regulations is often based on extensive scientific experiments, resulting in a certain degree of latency. Therefore, timely advancement in laboratory research is crucial to ensure the timely update and adaptability of regulations. A comprehensive understanding of the composition of cosmetic matrices and their pretreatment technologies is vital for enhancing the efficiency and accuracy of cosmetic detection. Drawing upon the China National Medical Products Administration’s 2021 Cosmetic Classification Rules and Classification Catalogue, we streamline the wide array of cosmetics into four principal categories based on the following compositions: emulsified, liquid, powdered, and wax-based cosmetics. In this review, the characteristics, compositional elements, and physicochemical properties inherent to each category, as well as an extensive overview of the evolution of pretreatment methods for different categories, will be explored. Our objective is to provide a clear and comprehensive guide, equipping researchers with profound insights into the core compositions and pretreatment methods of cosmetics, which will in turn advance cosmetic analysis and improve detection and regulatory approaches in the industry.
Process Optimization and Equilibrium, Thermodynamic, and Kinetic Modeling of Toxic Congo Red Dye Adsorption from Aqueous Solutions Using a Copper Ferrite Nanocomposite Adsorbent
Authors: Parimelazhagan Vairavel , Chinta Akhil , Shetty Gaurav Ganesh , Maddasani Srinivasulu , Tseng Wei-Lung , Ethiraj Jayashree , Ayyakannu Sundaram Ganeshraja , Kumar Alagarsamy Santhana Krishna
Published: January 2024

In the present investigation of copper ferrite, a CuFe2O4 nanocomposite adsorbent was synthesized using the sol–gel method, and its relevance in the adsorptive elimination of the toxic Congo red (CR) aqueous phase was examined. A variety of structural methods were used to analyze the CuFe2O4 nanocomposite; the as-synthesized nanocomposite had agglomerated clusters with a porous, irregular, rough surface that could be seen using FE-SEM, and it also contained carbon (23.47%), oxygen (44.31%), copper (10.21%), and iron (22.01%) in its elemental composition by weight. Experiments were designed to achieve the most optimized system through the utilization of a central composite design (CCD). The highest uptake of CR dye at equilibrium occurred when the initial pH value was 5.5, the adsorbate concentration was 125 mg/L, and the adsorbent dosage was 3.5 g/L. Kinetic studies were conducted, and they showed that the adsorption process followed a pseudo-second-order (PSO) model (regression coefficient, R2 = 0.9998), suggesting a chemisorption mechanism, and the overall reaction rate was governed by both the film and pore diffusion of adsorbate molecules. The process through which dye molecules were taken up onto the particle surface revealed interactions involving electrostatic forces, hydrogen bonding, and pore filling. According to isotherm studies, the equilibrium data exhibited strong agreement with the Langmuir model (R2 = 0.9989), demonstrating a maximum monolayer adsorption capacity (qmax) of 64.72 mg/g at pH 6 and 302 K. Considering the obtained negative ΔG and positive ΔHads and ΔSads values across all tested temperatures in the thermodynamic investigations, it was confirmed that the adsorption process was characterized as endothermic, spontaneous, and feasible, with an increased level of randomness. The CuFe2O4 adsorbent developed in this study is anticipated to find extensive application in effluent treatment, owing to its excellent reusability and remarkable capability to effectively remove CR in comparison to other adsorbents.
Trollius chinensis Bunge: A Comprehensive Review of Research on Botany, Materia Medica, Ethnopharmacological Use, Phytochemistry, Pharmacology, and Quality Control
Authors: He Lianqing , Wang Zhen , Lu Jiaxin , Qin Chen , He Jiajun , Ren Weichao , Liu Xiubo
Published: January 2024

Trollius chinensis Bunge, a perennial herb belonging to the Ranunculaceae family, has been extensively used in traditional Chinese medicine. Documented in the Supplements to the Compendium of Materia Medica, its medicinal properties encompass a spectrum of applications, including heat clearance, detoxification, alleviation of oral/throat sores, earaches, eye pain, cold-induced fever, and vision improvement. Furthermore, T. chinensis is used in clinical settings to treat upper respiratory infections, pharyngitis, tonsillitis, esoenteritis, canker, bronchitis, etc. It is mainly used to treat inflammation, such as inflammation of the upper respiratory tract and nasal mucosa. This comprehensive review explores the evolving scientific understanding of T. chinensis, covering facets of botany, materia medica, ethnopharmacological use, phytochemistry, pharmacology, and quality control. In particular, the chemical constituents and pharmacological research are reviewed. Polyphenols, mainly flavonoids and phenolic acids, are highly abundant among T. chinensis and are responsible for antiviral, antimicrobial, and antioxidant activities. The flower additionally harbors trace amounts of volatile oil, polysaccharides, and other bioactive compounds. The active ingredients of the flower have fewer side effects, and it is used in children because of its minimal side effects, which has great research potential. These findings validate the traditional uses of T. chinensis and lay the groundwork for further scientific exploration. The sources utilized in this study encompass Web of Science, Pubmed, CNKI site, classic monographs, Chinese Pharmacopoeia, Chinese Medicine Dictionary, and doctoral and master’s theses.