bluuebunny/crossref_metadata_2025 huggingface dataset:
Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep
Authors: Amodei Rebecka , Gribbin Kyle , He Wen , Lindgren Isa , Corder Keely R , Jonker Sonnet S , Estill Charles T , Coolen Lique M , Lehman Michael N , Whitler William , Stormshak Fred , Roselli Charles E
Published: February 2020

Evidence suggests that the hypothalamic–pituitary–gonadal (HPG) axis is active during the critical period for sexual differentiation of the ovine sexually dimorphic nucleus, which occurs between gestational day (GD) 60 and 90. Two possible neuropeptides that could activate the fetal HPG axis are kisspeptin and neurokinin B (NKB). We used GD85 fetal lambs to determine whether intravenous administration of kisspeptin-10 (KP-10) or senktide (NKB agonist) could elicit luteinizing hormone (LH) release. Immunohistochemistry and fluorescent in situ hybridization (FISH) were employed to localize these peptides in brains of GD60 and GD85 lamb fetuses. In anesthetized fetuses, KP-10 elicited robust release of LH that was accompanied by a delayed rise in serum testosterone in males. Pretreatment with the GnRH receptor antagonist (acyline) abolished the LH response to KP-10, confirming a hypothalamic site of action. In unanesthetized fetuses, senktide, as well as KP-10, elicited LH release. The senktide response of females was greater than that of males, indicating a difference in NKB sensitivity between sexes. Gonadotropin-releasing hormone also induced a greater LH discharge in females than in males, indicating that testosterone negative feedback is mediated through pituitary gonadotrophs. Kisspeptin and NKB immunoreactive cells in the arcuate nucleus were more abundant in females than in males. Greater than 85% of arcuate kisspeptin cells costained for NKB. FISH revealed that the majority of these were kisspeptin/NKB/dynorphin (KNDy) neurons. These results support the hypothesis that kisspeptin–GnRH signaling regulates the reproductive axis of the ovine fetus during the prenatal critical period acting to maintain a stable androgen milieu necessary for brain masculinization.
Tracking of Serum DHEAS Concentrations from Age 1 to 6 Years: A Prospective Cohort Study
Authors: Liimatta Jani , Jääskeläinen Jarmo , Karvonen Anne M , Remes Sami , Voutilainen Raimo , Pekkanen Juha
Published: February 2020

Context

Adrenarche is a gradual process, but its programming is unknown.

Objective

The objective of this article is to examine the trajectory of dehydroepiandrosterone sulfate (DHEAS) from age 1 to 6 years and the associations of early growth with DHEAS concentration by age 6 years.

Design and participants

Longitudinal data from a population sample of 78 children (43 girls) with serum samples for DHEAS and insulin-like growth factor 1 (IGF-1) measurements available at ages 1 and 6 years.

Main outcome measure

Serum DHEAS concentration at age 6 years.

Results

DHEAS concentration at age 1 year correlated with DHEAS concentration at age 6 years (r = 0.594, P < .001). DHEAS levels at age 6 years increased with tertiles of DHEAS at age 1 year (medians (µg/dL); 4.2, 14.4, 22.6; P < .001) and with those of greater increase in length by age 1 year (6.0, 11.7, 16.4; P = .047), and decreased with tertiles of birth length (17.7, 13.3, 7.1; P = .042). In a regression model including birth size, biochemical covariates at age 1 year, and growth measures by age 6 years, higher DHEAS concentration at age 1 year was an independent determinant of falling into the highest DHEAS tertile at age 6 years.

Conclusions

Higher serum DHEAS concentrations already at age 1 year are associated with those at age 6 years. Also, shorter birth length and rapid catch-up growth in length by age 1 year are associated with higher DHEAS concentrations at age 6 years. These results corroborate the early origin of adrenarche and strongly suggest that part of adrenarchal programming already takes place by the end of infancy.
Paediatric and adolescent anterior cruciate ligament reconstruction surgery
Authors: Nogaro Marie-Caroline , Abram Simon G. F. , Alvand Abtin , Bottomley Nicholas , Jackson William F. M. , Price Andrew
Published: February 2020

Aims

Anterior cruciate ligament (ACL) surgery in children and the adolescent population has increased steadily over recent years. We used a national database to look at trends in ACL reconstruction and rates of serious complications, growth disturbance, and revision surgery, over 20 years.

Methods

All hospital episodes for patients undergoing ACL reconstruction, under the age of 20 years, between 1 April 1997 and 31 March 2017, were extracted by procedure code from the national Hospital Episode Statistics (HES). Population standardized rates of intervention were determined by age group and year of treatment. Subsequent rates of serious complications including reoperation for infection, growth disturbance (osteotomy, epiphysiodesis), revision reconstruction, and/or contralateral ACL reconstruction rates were determined.

Results

Over the 20 year period, 16,125 ACL reconstructions were included. The mean age of patients was 16.9 years (SD 2.0; 27.1% female, n = 4,374/16,125). The majority of procedures were observed in the 15 to 19 years age group. The rate of ACL reconstruction increased 29-fold from 1997 to 1998, to 2016 to 2017. Within 90 days of ACL reconstruction, the rate of reoperation for infection was 0.31% (95% confidence interval (CI) 0.23 to 0.41, n = 50/16,125) and the rate of pulmonary embolism was 0.037% (95%.CI 0.014 to 0.081, n = 6/16,125). Of those with minimum five-year follow-up following ACL reconstruction (n = 7,585), 1.00% of patients subsequently underwent an osteotomy (95% CI 0.79 to 1.25, n = 76/7,585), 0.09% an epiphysiodesis (95% CI 0.04 to 0.19, n = 7/7,585), 7.46% revision ACL reconstruction (95% CI 6.88 to 8.08, n = 566/7,585), and 6.37% contralateral ACL reconstruction (95% CI 5.83 to 6.94, n = 483/7,585).

Conclusion

Rates of paediatric and adolescent ACL reconstruction have increased 29-fold over the last 20 years. Despite the increasing rate in the younger population, the risk of serious complications, including further surgery for growth disturbance is very low. The results of our study provide a point of reference for shared decision making in the management of ACL injury in the paediatric and adolescent population. Cite this article: Bone Joint J 2020;102-B(2):239–245.
Silastic first metatarsophalangeal joint arthroplasty for the treatment of end-stage hallux rigidus
Authors: Clough Timothy M. , Ring Joseph
Published: February 2020

Aims

Arthroplasty for end-stage hallux rigidus (HR) is controversial. Arthrodesis remains the gold standard for surgical treatment, although is not without its complications, with rates of up to 10% for nonunion, 14% for reoperation and 10% for metatarsalgia. The aim of this study was to analyze the outcome of a double-stemmed silastic implant (Wright-Medical, Memphis, Tennessee, USA) for patients with end-stage HR.

Methods

We conducted a retrospective review of 108 consecutive implants in 76 patients, between January 2005 and December 2016, with a minimum follow-up of two years. The mean age of the patients at the time of surgery was 61.6 years (42 to 84). There were 104 females and four males. Clinical, radiological, patient reported outcome measures (PROMS) data, a visual analogue score (VAS) for pain, and satisfaction scores were collected.

Results

The survivorship at a mean follow-up of 5.3 years (2.1 to 14.1) was 97.2%. The mean Manchester Oxford Foot and Ankle Questionnaire (MOXFQ) scores improved from 78.1 to 11.0, and VAS scores for pain from 7/10 to 1.3/10. The rate of satisfaction was 90.6%. Three implants (2.8%) required revision; one for infection, one-month postoperatively, and two for stem breakage at 10.4 and 13.3 years postoperatively. There was a 1.9% reoperation rate other than revision, 23.1% of patients developed a minor complication, and 21.1% of patients had non-progressive and asymptomatic cysts on radiological review.

Conclusion

We report a 97.2% survivorship at a mean follow-up of 5.3 years with this implant. We did not find progressive osteolysis, as has been previously reported. These results suggest that this double-stemmed silastic implant provides a predictable and reliable alternative with comparable outcomes to arthrodesis for the treatment of end-stage HR. Cite this article: Bone Joint J 2020;102-B(2):220–226.
Good implant survival after acetabular revision with extensive impaction bone grafting and uncemented components
Authors: Perlbach Rico , Palm Lars , Mohaddes Maziar , Ivarsson Ingemar , Schilcher Jörg
Published: February 2020

Aims

This single-centre observational study aimed to describe the results of extensive bone impaction grafting of the whole acetabular cavity in combination with an uncemented component in acetabular revisions performed in a standardized manner since 1993.

Methods

Between 1993 and 2013, 370 patients with a median age of 72 years (interquartile range (IQR) 63 to 79 years) underwent acetabular revision surgery. Of these, 229 were more than ten years following surgery and 137 were more than 15 years. All revisions were performed with extensive use of morcellized allograft firmly impacted into the entire acetabular cavity, followed by insertion of an uncemented component with supplementary screw fixation. All types of reoperation were captured using review of radiographs and medical charts, combined with data from the local surgical register and the Swedish Hip Arthroplasty Register.

Results

Among patients with possible follow-up of ten and 15 years, 152 and 72 patients remained alive without revision of the acetabular component. The number of deaths was 61 and 50, respectively. Of those who died, six patients in each group had a reoperation performed before death. The number of patients with a reoperation was 22 for those with ten-year follow-up and 21 for those with 15 years of follow-up. The Kaplan-Meier implant survival rate for aseptic loosening among all 370 patients in the cohort was 96.3% (95% confidence interval (CI) 94.1 to 98.5) after ten years and 92.8% (95% CI 89.2 to 96.6) after 15 years.

Conclusion

Extensive bone impaction grafting combined with uncemented revision components appears to be a reliable method with favourable long-term survival. This technique offers the advantage of bone stock restoration and disputes the long-standing perception that uncemented components require > 50% of host bone contact for successful implant survival. Cite this article: Bone Joint J 2020;102-B(2):198–204.
Better outcome for suture button compared with single syndesmotic screw for syndesmosis injury: five-year results of a randomized controlled trial
Authors: Ræder Benedikte W. , Figved Wender , Madsen Jan E. , Frihagen Frede , Jacobsen Silje B. , Andersen Mette Renate
Published: February 2020

Aims

In a randomized controlled trial with two-year follow-up, patients treated with suture button (SB) for acute syndesmotic injury had better outcomes than patients treated with syndesmotic screw (SS). The aim of this study was to compare clinical and radiological outcomes for these treatment groups after five years.

Methods

A total of 97 patients with acute syndesmotic injury were randomized to SS or SB. The five-year follow-up rate was 81 patients (84%). The primary outcome was the American Orthopaedic Foot and Ankle Society (AOFAS) Ankle Hindfoot Scale. Secondary outcome measures included Olerud-Molander Ankle (OMA) score, visual analogue scale (VAS), EuroQol five-dimension questionnaire (EQ-5D), range of movement, complications, reoperations, and radiological results. CT scans of both ankles were obtained after surgery, and after one, two, and five years.

Results

The SB group had higher median AOFAS score (100 (interquartile range (IQR) 92 to 100) vs 90 (IQR 85 to 100); p = 0.006) and higher median OMA score (100 (IQR 95 to 100) vs 95 (IQR 75 to 100); p = 0.006). The SS group had a higher incidence of ankle osteoarthritis (OA) (24 (65%) vs 14 (35%), odds ratio (OR) 3.4 (95% confidence interval (CI) 1.3 to 8.8); p = 0.009). On axial CT we measured a significantly smaller mean difference in the anterior tibiofibular distance between injured and non-injured ankles in the SB group (–0.1 mm vs 1.2 mm; p = 0.016).

Conclusion

Five years after syndesmotic injury treated with either SB or SS, we found better AOFAS and OMA scores, and lower incidence of ankle OA, in the SB group. These long-term results favour the use of SB when treating an acute syndesmotic injury. Cite this article: Bone Joint J 2020;102-B(2):212–219.
Periprosthetic osseointegration fractures are infrequent and management is familiar
Authors: Hoellwarth Jason S. , Tetsworth Kevin , Kendrew John , Kang Norbert Venantius , van Waes Oscar JF , Al-Maawi Qutaiba , Roberts Claudia , Al Muderis Munjed
Published: February 2020

Aims

Osseointegrated prosthetic limbs allow better mobility than socket-mounted prosthetics for lower limb amputees. Fractures, however, can occur in the residual limb, but they have rarely been reported. Approximately 2% to 3% of amputees with socket-mounted prostheses may fracture within five years. This is the first study which directly addresses the risks and management of periprosthetic osseointegration fractures in amputees.

Methods

A retrospective review identified 518 osseointegration procedures which were undertaken in 458 patients between 2010 and 2018 for whom complete medical records were available. Potential risk factors including time since amputation, age at osseointegration, bone density, weight, uni/bilateral implantation and sex were evaluated with multiple logistic regression. The mechanism of injury, technique and implant that was used for fixation of the fracture, pre-osseointegration and post fracture mobility (assessed using the K-level) and the time that the prosthesis was worn for in hours/day were also assessed.

Results

There were 22 periprosthetic fractures; they occurred exclusively in the femur: two in the femoral neck, 14 intertrochanteric and six subtrochanteric, representing 4.2% of 518 osseointegration operations and 6.3% of 347 femoral implants. The vast majority (19/22, 86.4%) occurred within 2 cm of the proximal tip of the implant and after a fall. No fractures occurred spontaneously. Fixation most commonly involved dynamic hip screws (10) and reconstruction plates (9). No osseointegration implants required removal, the K-level was not reduced after fixation of the fracture in any patient, and all retained a K-level of ≥ 2. All fractures united, 21 out of 22 patients (95.5%) wear their osseointegration-mounted prosthetic limb longer daily than when using a socket, with 18 out of 22 (81.8%) reporting using it for ≥ 16 hours daily. Regression analysis identified a 3.89-fold increased risk of fracture for females (p = 0.007) and a 1.02-fold increased risk of fracture per kg above a mean of 80.4 kg (p = 0.046). No increased risk was identified for bilateral implants (p = 0.083), time from amputation to osseointegration (p = 0.974), age at osseointegration (p = 0.331), or bone density (g/cm2, p = 0.560; T-score, p = 0.247; Z-score, p = 0.312).

Conclusion

The risks and sequelae of periprosthetic fracture after press-fit osseointegration for amputation should not deter patients or clinicians from considering this procedure. Females and heavier patients are likely to have an increased risk of fracture. Age, years since amputation, and bone density do not appear influential. Cite this article: Bone Joint J 2020;102-B(2):162–169.
The Ellipse modification of the Friedman method for measuring glenoid version
Authors: Javed Saqib , Hadi Saif , Imam Mohamed A. , Gerogiannis Dimitris , Foden Philip , Monga Puneet
Published: February 2020

Aims

Accurate measurement of the glenoid version is important in performing total shoulder arthroplasty (TSA). Our aim was to evaluate the Ellipse method, which involves formally defining the vertical mid-point of the glenoid prior to measuring the glenoid version and comparing it with the ‘classic’ Friedman method.

Methods

This was a retrospective study which evaluated 100 CT scans for patients who underwent a primary TSA. The glenoid version was measured using the Friedman and Ellipse methods by two senior observers. Statistical analyses were performed using the paired t-test for significance and the Bland-Altman plot for agreement.

Results

The mean glenoid version was -3.11° (-23.8° to 17.9°) using the Friedman method and -1.95° (-29.8° to 24.6°) using the Ellipse method (p = 0.002). In 16 patients the difference between methods was greater than 5°, which we considered to be clinically significant. There was poor agreement between methods with relatively large 95% limits of agreement. There was excellent inter-rater agreement between the observers for the Ellipse method and similarly, the intrarater agreement was excellent with a repeatability coefficient of 0.94.

Conclusion

We recommend the use of the Ellipse modification to define the mid glenoid point prior to measuring the glenoid version in patients undergoing TSA. Cite this article: Bone Joint J 2020;102-B(2):232–238.
Short-term outcomes with the REDAPT monolithic, tapered, fluted, grit-blasted, forged titanium revision femoral stem
Authors: Gabor Jonathan A. , Padilla Jorge A. , Feng James E. , Schnaser Erik , Lutes William B. , Park Kwan J. , Incavo Stephen , Vigdorchik Jonathan , Schwarzkopf Ran
Published: February 2020

Aims

Although good clinical outcomes have been reported for monolithic tapered, fluted, titanium stems (TFTS), early results showed high rates of subsidence. Advances in stem design may mitigate these concerns. This study reports on the use of a current monolithic TFTS for a variety of indications.

Methods

A multi-institutional retrospective study of all consecutive total hip arthroplasty (THA) and revision total hip arthroplasty (rTHA) patients who received the monolithic TFTS was conducted. Surgery was performed by eight fellowship-trained arthroplasty surgeons at four institutions. A total of 157 hips in 153 patients at a mean follow-up of 11.6 months (SD7.8) were included. Mean patient age at the time of surgery was 67.4 years (SD 13.3) and mean body mass index (BMI) was 28.9 kg/m2 (SD 6.5). Outcomes included intraoperative complications, one-year all-cause re-revisions, and subsidence at postoperative time intervals (two weeks, six weeks, six months, nine months, and one year).

Results

There were eight intraoperative complications (4.9%), six of which were intraoperative fractures; none occurred during stem insertion. Six hips (3.7%) underwent re-revision within one year; only one procedure involved removal of the prosthesis due to infection. Mean total subsidence at latest follow-up was 1.64 mm (SD 2.47). Overall, 17 of 144 stems (11.8%) on which measurements could be performed had >5 mm of subsidence, and 3/144 (2.1%) had >10 mm of subsidence within one year. A univariate regression analysis found that additional subsidence after three months was minimal. A multivariate regression analysis found that subsidence was not significantly associated with periprosthetic fracture as an indication for surgery, the presence of an extended trochanteric osteotomy (ETO), Paprosky classification of femoral bone loss, stem length, or type of procedure performed (i.e. full revision vs conversion/primary).

Conclusion

Advances in implant design, improved trials, a range of stem lengths and diameters, and high offset options mitigate concerns of early subsidence and dislocation with monolithic TFTS, making them a valuable option for femoral revision. Cite this article: Bone Joint J 2020;102-B(2):191–197.
Retrospective cohort study of 68 sacral giant cell tumours treated with nerve-sparing surgery and evaluation on therapeutic benefits of denosumab therapy
Authors: Lim Chiao Yee , Liu Xingyu , He Fangzhou , Liang Haijie , Yang Yi , Ji Tao , Yang Rongli , Guo Wei
Published: February 2020

Aims

To investigate the benefits of denosumab in combination with nerve-sparing surgery for treatment of sacral giant cell tumours (GCTs).

Methods

This is a retrospective cohort study of patients with GCT who presented between January 2011 and July 2017. Intralesional curettage was performed and patients treated from 2015 to 2017 also received denosumab therapy. The patients were divided into three groups: Cohort 1: control group (n = 36); cohort 2: adjuvant denosumab group (n = 9); and cohort 3: neo- and adjuvant-denosumab group (n = 17).

Results

There were 68 patients within the study period. Six patients were lost to follow-up. The mean follow-up was 47.7 months (SD 23.2). Preoperative denosumab was found to reduce intraoperative haemorrhage and was associated with shorter operating time for tumour volume > 200 cm3. A total of 17 patients (27.4%) developed local recurrence. The locoregional control rate was 77.8% (7/9) and 87.5% (14/16) respectively for cohorts 2 and 3, in comparison to 66.7% (24/36) of the control group. The recurrence-free survival (RFS) rate was significantly higher for adjuvant denosumab group versus those without adjuvant denosumab during the first two years: 100% vs 83.8% at one year and 95.0% vs 70.3% at two years. No significant difference was found for the three-year RFS rate.

Conclusion

Preoperative denosumab therapy was found to reduce intraoperative haemorrhage and was associated with shorter operating times. Adjuvant denosumab was useful to prevent early recurrence during the first two years after surgery. Cite this article: Bone Joint J 2020;102-B(2):177–185.
Supine flexibility predicts curve progression for patients with adolescent idiopathic scoliosis undergoing underarm bracing
Authors: Cheung Jason P. Y. , Cheung Prudence W. H.
Published: February 2020

Aims

The aim of this study was to assess whether supine flexibility predicts the likelihood of curve progression in patients with adolescent idiopathic scoliosis (AIS) undergoing brace treatment.

Methods

This was a retrospective analysis of patients with AIS prescribed with an underarm brace between September 2008 to April 2013 and followed up until 18 years of age or required surgery. Patients with structural proximal curves that preclude underarm bracing, those who were lost to follow-up, and those who had poor compliance to bracing (<16 hours a day) were excluded. The major curve Cobb angle, curve type, and location were measured on the pre-brace standing posteroanterior (PA) radiograph, supine whole spine radiograph, initial in-brace standing PA radiograph, and the post-brace weaning standing PA radiograph. Validation of the previous in-brace Cobb angle regression model was performed. The outcome of curve progression post-bracing was tested using a logistic regression model. The supine flexibility cut-off for curve progression was analyzed with receiver operating characteristic curve.

Results

A total of 586 patients with mean age of 12.6 years (SD 1.2) remained for analysis after exclusion. The baseline Cobb angle was similar for thoracic major curves (31.6° (SD 3.8°)) and lumbar major curves (30.3° (SD 3.7°)). Curve progression was more common in the thoracic curves than lumbar curves with mean final Cobb angles of 40.5° (SD 12.5°) and 31.8° (SD 9.8°) respectively. This dataset matched the prediction model for in-brace Cobb angle with less mean absolute error in thoracic curves (0.61) as compared to lumbar curves (1.04). Reduced age and Risser stage, thoracic curves, increased pre-brace Cobb angle, and reduced correction and flexibility rates predicted increased likelihood of curve progression. Flexibility rate of more than 28% has likelihood of preventing curve progression with bracing.

Conclusion

Supine radiographs provide satisfactory prediction for in-brace correction and post-bracing curve magnitude. The flexibility of the curve is a guide to determine the likelihood for brace success. Cite this article: Bone Joint J 2020;102-B(2):254–260.
Satisfactory functional and MRI outcomes at the foot and ankle following harvesting of full thickness peroneus longus tendon graft
Authors: Shao Xiexiang , Shi Lewis L. , Bluman Eric M. , Wang Shaobai , Xu Xiaoming , Chen Xiaodong , Wang Jianhua
Published: February 2020

Aims

To evaluate the donor site morbidity and tendon morphology after harvesting whole length, full-thickness peroneus longus tendon (PLT) proximal to the lateral malleolus for ligament reconstructions or tendon transfer.

Methods

A total of 21 eligible patients (mean age 34.0 years (standard deviation (SD) 11.2); mean follow-up period 31.8 months (SD 7.7), and 12 healthy controls (mean age, 26.8 years (SD 5.9) were included. For patients, clinical evaluation of the donor ankle was performed preoperatively and postoperatively. Square hop test, ankle strength assessment, and MRI of distal calf were assessed bilaterally in the final follow-up. The morphological symmetry of peroneal tendons bilaterally was evaluated by MRI in healthy controls.

Results

Among the patients, the mean pre- and postoperative American Orthopaedic Foot and Ankle Society (AOFAS) hindfoot score and Karlsson-Peterson score were 98.7 (SD 2.5; p = 0.480) and 98.5 (SD 2.4; p = 0.480), and 98.3 (SD 2.4; p = 0.162) and 97.9 (SD 2.5; p = 0.162), respectively. There was no significant difference between square hop test bilaterally (p = 0.109) and plantar flexion peak force bilaterally (p = 0.371). The harvested limb had significantly less eversion peak force compared to the contralateral limb (p < 0.001). Evidence of probable tendon regeneration was observed in all the patients by MRI and the total bilateral peroneal tendon index (mean ratio of harvested side cross-sectional area of peroneal tendon compared with the contralateral side) was 82.9% (SD 17.4). In 12 healthy controls, peroneal tendons (mean 99.4% (SD 4.3) were found to be morphologically symmetrical between the two sides.

Conclusion

The current study showed satisfactory clinical foot and ankle outcomes after full-thickness PLT harvesting and indicated the regenerative potential of PLT after its removal. Level of Evidence: Level IV, therapeutic retrospective case series. Cite this article: Bone Joint J 2020;102-B(2):205–211.
Bone health in adolescents with idiopathic scoliosis
Authors: Diarbakerli Elias , Savvides Panayiotis , Wihlborg Axel , Abbott Allan , Bergström Ingrid , Gerdhem Paul
Published: February 2020

Aims

Idiopathic scoliosis is the most common spinal deformity in adolescents and children. The aetiology of the disease remains unknown. Previous studies have shown a lower bone mineral density in individuals with idiopathic scoliosis, which may contribute to the causation. The aim of the present study was to compare bone health in adolescents with idiopathic scoliosis with controls.

Methods

We included 78 adolescents with idiopathic scoliosis (57 female patients) at a mean age of 13.7 years (8.5 to 19.6) and 52 age- and sex-matched healthy controls (39 female patients) at a mean age of 13.8 years (9.1 to 17.6). Mean skeletal age, estimated according to the Tanner-Whitehouse 3 system (TW3), was 13.4 years (7.4 to 17.8) for those with idiopathic scoliosis, and 13.1 years (7.4 to 16.5) for the controls. Mean Cobb angle for those with idiopathic scoliosis was 29° (SD 11°). All individuals were scanned with dual energy x-ray absorptiometry (DXA) and peripheral quantitative CT (pQCT) of the left radius and tibia to assess bone density. Statistical analyses were performed with independent-samples t-test, the Mann-Whitney U test, and the chi-squared test.

Results

Compared with controls, adolescents with idiopathic scoliosis had mean lower DXA values in the left femoral neck (0.94 g/cm2 (SD 0.14) vs 1.00 g/cm2 (SD 0.15)), left total hip (0.94 g/cm2 (SD 0.14) vs 1.01 g/cm2 (SD 0.17)), L1 to L4 (0.99 g/cm2 (SD 0.15) vs 1.06 g/cm2 (SD 0.17)) and distal radius (0.35 g/cm2 (SD 0.07) vs 0.39 g/cm2 (SD 0.08; all p ≤ 0.024), but not in the mid-radius (0.72 g/cm2 vs 0.74 g/cm2; p = 0.198, independent t-test) and total body less head (1,559 g (SD 380) vs 1,649 g (SD 492; p = 0.0.247, independent t-test). Compared with controls, adolescents with idiopathic scoliosis had lower trabecular volume bone mineral density (BMD) on pQCT in the distal radius (184.7 mg/cm3 (SD 40.0) vs 201.7 mg/cm3 (SD 46.8); p = 0.029), but not in other parts of the radius or the tibia (p ≥ 0.062, Mann-Whitney U test).

Conclusion

In the present study, idiopathic scoliosis patients seemed to have lower BMD at central skeletal sites and less evident differences at peripheral skeletal sites when compared with controls. Cite this article: Bone Joint J 2020;102-B(2):268–272
Career progression after core surgical training
Authors: Ralph J , Ashwell A , Bradburn M , Jones S
Published: February 2020

We examine the employment journey of doctors who successfully complete core training.
Structural and vibrational spectroscopic studies of new phases with sillenite type in the system Bi2O3- In2O3 –MgO
Authors: Ait Oulahyane Hajar , Chagraoui Abdeslam , Loubbidi Leila , Bourja Lamia , Ait Sidi Ahmed Omar , Tairi Abdelmjid
Published: February 2020

The anion and cation deficient phase Bi0.95 In0.05 O1.5 (Bi1.9 In0.1 O3) was synthesized and experimentally investigated using X-ray diffraction and vibrational spectroscopy (Infrared and Raman). The non-stoichiometric phases are similar to sillenite family type γBi2O3 and crystallize in the I23 space group. The crystal structure was determined by full profile Rietveld analysis of the powder diffractogram. It is formed by a sequence of BiO5E polyhedra (E lone pair of bismuth) and MO4 polyhedra (M = In, Mg). The set of MO4 polyhedra are localized in cavities generated by BiO5E polyhedra. The vibrational spectroscopic study revealed the existence of three regions; low, intermediate and high-frequency region. They are attributed to Bi-O stretching mode, In / Mg-O vibrations and cationic displacements respectively.
Electrochemical oxidation of textile azo dye reactive orange 16 on the Platinum electrode
Authors: El Aggadi Sanaa , Loudiyi Nidae , Chadil Aicha , Cherkaoui Omar , El Hourch Abderrahim
Published: February 2020

This study focused mainly on the color removal of textile azo dye Reactive Orange 16 (RO16) by electrochemical oxidation. The effect of supporting electrolyte (H2SO4 and NaOH), RO16 concentration (from 0.5 to 10 mM) and potential scan rate (between 20 and 500 mV/s) was performed with cyclic voltammetry using platinum (Pt) wire as working electrode. The anodic peak current density was linear to RO16 concentrations. This allows the lowest concentrations to be determined voltammetrically in the two electrolytic media, acid (H2SO4 1 M) and alkaline (NaOH 0.1 M). Linearity between the current density and the square root of the potential scan rate was observed in both electrolytes. This means that the electrochemical reaction at the electrode-electrolyte interface is controlled by the diffusion process. The slope of the logarithm of peak current density versus the logarithm of potential scan rate was found to be 0.43 for RO16 in H2SO4 and 0.48 in NaOH these values of slop are close to the thеoretical value of 0.5 which confirms the diffusion process. The removal efficiency of the dye in acid electrolyte reached 40%, while it is 18% in the basic media after 4 hours of electrolysis by chronoamperometry.
Successful policy transfer and public sector reform in developing countries
Authors: Ugyel Lhawang , Daugbjerg Carsten
Published: February 2020

The scope and intensity of policy transfer has increased in recent years as developing countries have drawn on public sector reform programmes based on new public management practices originally designed in western democracies. However, there is mounting evidence that to be successful, reform programmes must be adapted to local contexts. This article demonstrates that national government control of policy transfer can enable localisation which in turn enhances the effectiveness of public reforms. Analysis of the Position Classification System – which sought to enhance accountability, efficiency and professionalism in the civil service in Bhutan – highlights two conditions that enable domestic control of the policy transfer process: strong internal motivation for engaging in policy transfer and the establishment or adaptation of institutions to manage processes of policy transfer. We conclude that when these conditions apply, a developing country can engage in successful voluntary policy transfer and retain control of the process.
‘Small project, big difference’: capacity building through a national volunteering fund: an evaluation of the Department of Health’s Health and Social Care Volunteering Fund
Authors: Warwick-Booth Louise , South Jane , Giuntoli Gianfranco , Kinsella Karina , White Judy
Published: February 2020

This article reports the findings of a mixed-methods evaluation study on the impact of a national fund to support volunteering as a mechanism to achieve health and social goals, within the Health and Social Care Volunteering Fund (HSCVF) programme, established by the formerly named Department of Health (now the Department of Health and Social Care). The article adds understanding of the mechanisms through which government organisations can build voluntary, community and social enterprise (VCSE) organisational capacity to support volunteers. First, the programme increased capacity via resource mobilisation to enhance volunteer recruitment; second, it strengthened VCSE organisations through partnerships/linkages/networking; and finally, it supported learning and skills development. The HSCVF impacted on both volunteering projects and host organisations to produce a range of positive outcomes that were particularly marked in smaller organisations: ‘small project, big difference’. Successful community capacity building can result from programmes such as HSCVF, with this article contributing to the evidence base by detailing the processes through which this occurred.
When equal partners become unequal parents: couple relationships and intensive parenting culture
Authors: Faircloth Charlotte
Published: February 2020

Based on longitudinal research with (heterosexual) couples in the UK, this article tracks their experiences of becoming parents for the first time. The suggestion is that new parents are caught in an uncomfortable confluence between competing discourses around ideal relationships and those around ideal parenting. On the one hand, they must be committed to egalitarian ideals about the division of care. On the other, they must be parenting ‘intensively’, in ways which are markedly more demanding for mothers, and which makes paternal involvement more complicated.

Drawing on accounts of relationship difficulties, elicited over a five-year period, the article demonstrates the incommensurability of these ideals at physiological, material and ideological levels. As a contribution to the body of work known as parenting culture studies, this article brings, for the first time, an empirical focus to the question of how an ‘intensive’ parenting culture affects couples, rather than just mothers or fathers.
Hologram conversion for speckle free reconstruction using light field extraction and deep learning
Authors: Park Dae-Youl , Park Jae-Hyeung
Published: February 2020

A novel hologram conversion technique for speckle-less reconstruction is proposed. Many speckle-less reconstruction methods require holograms specially created for those techniques, limiting their applications to general pre-existing holograms. The proposed technique transforms an existing hologram with random phase distribution to new holograms for the application of the speckle-less reconstruction methods. The proposed technique first extracts a set of orthographic views from the existing hologram, then the extracted orthographic views are processed for the speckle noise removal using convolutional neural network. The processed orthographic views are finally used to synthesize new holograms with desired carrier waves by using non-hogel based computer generated hologram technique. The selection of the carrier wave is determined by the desired speckle-less reconstruction method. In this paper, we demonstrate the proposed technique with two speckle-less reconstruction methods; i.e. temporal speckle averaging of different random phase distributions and time-multiplexing of interleaved angular spectrums.
High-quality versatile photonic sources for multiple quantum optical experiments
Authors: Xu Zhao-Huai , Li Yin-Hai , Zhou Zhi-Yuan , Liu Shi-Long , Li Yan , Liu Shi-Kai , Yang Chen , Guo Guang-Can , Shi Bao-Sen
Published: February 2020

Entangled sources are important components for quantum information science and technology (QIST). The ability to generate high-quality entangled sources will determine the extent of progress in this field. Unlike previous schemes, a thin quasi-phase matching nonlinear crystal and a dense-wave-division-multiplexing device are used here to build high-quality versatile photonic sources with a simple configuration that can be used to perform Hong-Ou-Mandel interference, time-energy entanglement and multi-channel polarization entanglement experiments. The measurement results from various quantum optical experiments show the high quality of these photonic sources. These multi-functional photonic sources will be very useful in a variety of QIST applications.
Detection of phenol by incorporation of gold modified-enzyme based graphene oxide thin film with surface plasmon resonance technique
Authors: Hashim Hazwani Suhaila , Fen Yap Wing , Sheh Omar Nur Alia , Abdullah Jaafar , Daniyal Wan Mohd Ebtisyam Mustaqim Mohd , Saleviter Silvan
Published: February 2020

In this study, the incorporation between gold modified-tyrosinase (Tyr) enzyme based graphene oxide (GO) thin film with surface plasmon resonance (SPR) technique has been developed for the detection of phenol. SPR signal for the thin film contacted with phenol solution was monitored using SPR technique. From the SPR curve, sensitivity, full width at half maximum (FWHM), detection accuracy (DA) and signal-to-noise ratio (SNR) have been analyzed. The sensor produces a linear response for phenol up to 100 µM with sensitivity of 0.00193° µM−1. Next, it can be observed that deionized water has the lowest FWHM, with a value of 1.87° and also the highest value of DA. Besides, the SNR of the SPR signal was proportional to the phenol concentrations. Furthermore, the surface morphology of the modified thin film after exposed with phenol solution observed using atomic force microscopy showed a lot of sharp peaks compared to the image before in contact with phenol proved the interaction between the thin film and phenol.
Label-free biomechanical nanosensor based on LSPR for biological applications
Authors: Salbini M. , Stomeo T. , Ciracì C. , Fiammengo R. , Mangini V. , Toma A. , Pisano F. , Pisanello F. , Verri T. , Smith D. R. , De Vittorio M.
Published: February 2020

A label-free localized surface plasmon resonance (LSPR)-based biosensor exploiting gold nanorods (GNRs) is proposed and demonstrated. For this aim, 35 ± 5 nm long and 20 ± 4 thick GNRs spaced by a few nanometers thick polyelectrolytes (PE) from a gold thin film was analyzed and synthesized. The morphology of the GNRs, the plasmon properties of GNRs, swelling of PE layers and the wettability of the surfaces were characterized by transmission and scanning electron microscopy, spectroscopic reflectivity and contact angle measurements, respectively. Indeed, when immersed in a phosphate buffer saline solution, the GNRs-PE-gold system shows an optical shift of the LSPR wavelength. This shift was found to correspond to a vertical swelling of about 2 nm, demonstrating the extreme sensitivity of the biosensor. Finally, we show that LSPR measurements can be used to detect dynamic resonance changes in response to both thickness and buffer solution, while the hydrophobic behavior of the surface can be exploited for reducing the number of liquid analytes in clinical biosensing application.
Between nature and culture: Jakob von Uexküll's concept of Umwelten and how photography shapes our worlds
Authors: Froese Joachim
Published: February 2020

This article addresses traditional perceptions about photography's position between nature and culture and concomitant schools of thinking focusing pre-dominantly on the photographic image as a form of visual representation. Aiming to develop an alternative perspective it considers a biosemiotic approach and turns to Jakob von Uexküll's model of subjective sentient worlds (Umwelt) that critically dissolves the perceived dualism between nature and culture that has also underpinned most theoretical thinking about photography in the past. Today photography is largely embedded into social media platforms and their interlinked digital networks, which holds far-reaching consequences for a medium that in this current form can only be fully understood if it is considered as a form of embodied material practice. Aiming to understand some of the complex manifestations this technical evolution entails the article further considers the relevance of recent non-representational concepts arising out of cognition theory and cultural geography and uses the 'selfie' as a 'theoretical object'.
Photographic art and technology in contemporary India
Authors: Blaney Aileen
Published: February 2020

The algorithmic turn in photography raises the question of whether an algorithmically generated image is even a photograph at all. This paradox is abundant on India's urban streets, where the pedestrian or road user is met with giant photo saturated flex hoardings printed with political and community messages and photo-shopped portraits of gods, chief ministers and party workers. In this article, attention to photo-based political posters alongside art practices sharing common elements of digital capture and postproduction contextualizes a reading of technologically produced visual landscapes in the South Indian city of Bangalore. Informed by Vilèm Flusser, the techno-materiality of hoardings are interpreted as visual practices whose reliance on Microsoft and Adobe softwares reveal more than the semiotic information that is ostensibly transmitted; in so doing the extent to which photography is a useful entry point for assessing the visuality in which we're currently living and how this gets locally inflected in the case of India is explored.
Adrian Piper's aesthetic agency: Photography as catalysis for resisting neo-liberal competitive paradigms
Authors: Puymbroeck Gerlinde Van
Published: February 2020

Contemporary neo-liberal society is ruled by the market. Davies, Chen and Lentin and Titley show that its objectification and categorization founds a competitive notion of agency that disables subjective construction of self and intersubjective understanding of the world. As the market's rules and norms are set by white patriarchy, its competitive paradigm structurally disadvantages others. Art too is objectified and categorized by neo-liberal institutions, equally embedded in white patriarchal market structures and severely limiting democratic public access to a diverse artistic field, argue hooks, Mercer and Piper. Yet, Piper's artwork shows, art holds emancipatory potential. Defined as transforming experience, its ambiguity provides a structure for constituting agentic subjectivity and intersubjective signification processes, defying objective/objectifying market workings. Photography's specific qualities allow Piper to democratize access to the paradigm she proposes. Her artistic choices may thus found the potential to publicly construct a notion of aesthetic agency as resistance to the neo-liberal market.
Photographic manipulation in the health, clinical and biomedical sciences
Authors: Schneider Catherine , Hoffmann Sydney , Rowles Graham D.
Published: February 2020

Photography has become a pervasive component of contemporary communication. Recent technological advances in creating and manipulating images have provided renewed impetus to decades-long debates on use of photographs in science. With increase in the potential for inappropriate image manipulation, fears about misrepresentation have heightened concern among journal editors and scholars about the 'accuracy' of published images. We discuss how science has responded to growing concerns surrounding falsification and inaccuracy of photography. We document progress in implementing a variety of complementary approaches to addressing the problem. These include digital forensics, photo member checking and the implementation of codes of ethics to enhance the veracity of published photographs in science research. We conclude by acknowledging the irreducible conflict likely to remain between use of the photograph as a creative work of art and employment of this medium as a source of information in the progress of science.
This misery of light – light as destruction in the work of Lina Selander
Authors: Larsson Erika
Published: February 2020

In this article I look at two works by Swedish video artist Lina Selander and explore how underlying visual patterns unfold in these works that are connected to certain worldly phenomena. Borrowing from Jacques Derrida, I describe the tendency of being en mal d'archive as an obsession to structure the world into particular recognizable patterns. I argue that Selander's works can be understood as the unfolding of such structures, the result being that the very impulse itself, the obsession Derrida speaks of, comes to the forefront. In several of Selander's works, light is explored both as a basis and prerequisite for photography and as a metaphor for this potentially destructive desire for all-encompassing knowledge and structure. As such, I argue, the unfolding that takes place in her works can be understood as paradoxically increasing the shadows – as a way of undoing the totalizing effect of light and articulating modes of not knowing or mystery in relation to the phenomena explored.
Where is the photography of Non-Photography?
Authors: Whittaker Ed
Published: February 2020

François Laruelle's writing on Non-Photography is examined from its ontological condition to its desired form of a unity derived from the work of Kant, discussing precisely how the logic of transcendence and the ontology of immanence central to Laruelle's theory impact on how the photographic image is incontrovertibly involved with Kant's paradox of appearance and reality. In a context of burgeoning technoscience, which lays bare the meaning of Non-Photography for the seemingly impossible reversion to actual photography, the article goes on to consider Photo-Fiction in the context of the Real of science now yoked to an economy of technical models. But by foreclosing the Kantian Real by fractal–virtual ratio, does not this science reify the Real of Identity and displace real photography with a photography in the Real? The article thus questions how Laruelle's' thesis hangs together in terms of its cause and the contingency of effect that infuses Laruelle's radical aesthetic.