bluuebunny/crossref_metadata_2025 huggingface dataset:
Self‐reported pain interference and symptoms of anxiety and depression in community‐dwelling older adults: Can a temporal relationship be determined?
Authors: Arola Heidi‐Maria , Nicholls Elaine , Mallen Christian , Thomas Elaine
Published: April 2010

Pain and symptoms of depression and anxiety have been observed to co‐exist in the community‐dwelling elderly. While depression and pain have been suggested to be predictive of one another temporally, the longitudinal associations between anxiety and pain remain undefined. The aim of this study was to investigate the reciprocal longitudinal associations of self‐reported pain interference and affective symptoms, as measured by the Hospital Anxiety and Depression Scale, in community‐dwelling older adults and report the potentially modifying effect of co‐morbid anxiety or depression on these relationships. The study population were adults aged over 50‐years, recruited previously to the North Staffordshire Osteoarthritis project (NorStOP), who had returned a health survey at both baseline and 3‐year follow‐up (n = 4234). Logistic regression was used to evaluate the pain–affect associations, with associations expressed as odds ratios with 95% confidence intervals (CI). Probable depression (odds ratio = 2.42; 95% CI 1.24, 4.69) and anxiety (2.30; 1.67, 3.17) at baseline predicted new‐onset pain interference at 3‐year follow‐up. Conversely, pain interference at baseline was a risk factor for developing possible or probable depression (2.47; 1.96, 3.11) and anxiety (2.02; 1.60, 2.55) at 3‐year follow‐up. Adjusting for age, gender and co‐morbid anxiety or depression slightly reduced the strength of the relationships, though most remained statistically significant. In conclusion, we have found evidence for both pain–depression and pain–anxiety relationships longitudinally, and in a reciprocal manner. Such findings have important implications for the future management of primary care patients presenting with symptoms of pain, anxiety or depression.
A Niche for Microfluidics in Portable Hematology Analyzers
Authors: Heikali Daniel , Di Carlo Dino
Published: April 2010

The complete blood count (CBC) has by and large remained confined to the traditional laboratory setting since its inception. Used in a variety of diagnostic assessments, the CBC has essentially become limited to clinical laboratories because of reliance on large automated hematology devices. With many potential uses at the point of care and clinical settings, as well as the research laboratory, a portable low-cost hematology analyzer could aid in earlier detection of a wide variety of medical conditions. Using smaller sample volumes, inexpensive polymers, and low power consumption, microfluidic devices present one such route toward miniaturization of the traditional flow cytometer-based hematology analyzers. This review focuses on challenges for development of cost-effective portable analyzers, potential areas for point-of-care clinical usage, current commercial systems with increasing portability, and recent research in improved miniaturization and automation, including developments in acoustic and inertial focusing techniques and novel detection methodologies.
In vitro gas production of leaves from fodder trees and shrubs from mid-hills of Nepal using cow, sheep and goat rumen liquor
Authors: DEGEN A. A. , KAM M. , PANDEY S. B. , UPRETI C. R. , EL-MECCAWI S. , OSTI N. P.
Published: April 2010

In vitro gas production (GP) of substrate incubated with cow rumen liquor is commonly used to evaluate feed nutritional quality; GP is correlated with organic matter digestibility and metabolizable energy content. The hypothesis tested was that GP differs among liquors of ruminant species and is dependent on the natural dietary intake of the donors. Measurements were of 24 h GP of seven browse species using rumen liquor from a large (cow) and small (sheep) grazer and from a small intermediate feeder (goat). Mean GP for browse with goat liquor (7±2·4 ml per 200 mg substrate) was significantly (P=0·019) higher than that with cow liquor (5±1·9 ml), and GP with sheep liquor (6±1·1 ml) was intermediate, not significantly different from the cow liquor (P=0·197) and the goat liquor (P=0·061). There was a significant correlation in the ranking of the browses between goat and sheep (P=0·013) liquor using a Mantel test with 9999 permutations, which indicated a similar ranking of browses when using rumen liquor of either of these small ruminants. There were trends between both cow and sheep (P=0·096) and cow and goat (P=0·092) liquors. It was concluded that the dietary habits of ruminant species donors may affect in vitro nutritional studies when using rumen liquor.
The Image-Makers' Arsenal in an Age of War and Empire, 1898–1899: A Cartoon Essay, Featuring the Work of Charles Bartholomew (of the Minneapolis Journal) and Albert Wilbur Steele (of the Denver Post)
Authors: MILLER BONNIE M.
Published: April 2010

Utilizing the work of two cartoonists who produced for newspapers outside the central establishment of the yellow press, this essay argues for the critical role of political cartoonists in shaping viewers' expectations of US involvement in the Spanish-American War of 1898. It features seventeen cartoons, arranged carefully to reflect the shifting political climate, in order to demonstrate the narrative frameworks, image selections, and paradigm shifts in their representations of war and empire. Their cartoons were emblematic of how artists nationwide harnessed typographies of gender, race, and sexuality to create compelling justifications for and against policies of war and colonial acquisition.
Schistosomes of small mammals from the Lake Victoria Basin, Kenya: new species, familiar species, and implications for schistosomiasis control
Authors: HANELT B. , MWANGI I. N. , KINUTHIA J. M. , MAINA G. M. , AGOLA L. E. , MUTUKU M. W. , STEINAUER M. L. , AGWANDA B. R. , KIGO L. , MUNGAI B. N. , LOKER E. S. , MKOJI G. M.
Published: April 2010

Recent schistosomiasis control efforts in sub-Saharan Africa have focused nearly exclusively on treatment of humans with praziquantel. However, the extent to which wild mammals act as reservoirs forSchistosoma mansoniand therefore as sources of renewed transmission following control efforts is poorly understood. With the objective to study the role of small mammals as reservoir hosts, 480 animals belonging to 9 rodent and 1 insectivore species were examined for infection with schistosomes in Kisumu, in the Lake Victoria Basin, Kenya. Animals were collected from 2 sites: near the lakeshore and from Nyabera Marsh draining into the lake. A total of 6·0% of the animals captured, including 5 murid rodent species and 1 species of shrew (Crocidura olivieri) were infected with schistosomes. Four schistosome species were recovered and identified usingcox1 DNA barcoding:S. mansoni,S. bovis,S. rodhainiandS. kisumuensis, the latter of which was recently described from Nyabera Marsh.Schistosoma mansoniandS. rodhainiwere found infecting the same host individual (Lophuromys flavopunctatus), suggesting that this host species could be responsible for the production of hybrid schistosomes found in the area. Although the prevalence ofS. mansoniinfection in these reservoir populations was low (1·5%), given their potentially vast population size, their impact on transmission needs further study. Reservoir hosts could perpetuate snail infections and favour renewed transmission to humans once control programmes have ceased.
Genotype and subtype analysis of Cryptosporidium isolates from calves and lambs in Galicia (NW Spain)
Authors: DÍAZ PABLO , QUÍLEZ JOAQUÍN , CHALMERS RACHEL M. , PANADERO ROSARIO , LÓPEZ CEFERINO , SÁNCHEZ-ACEDO CARIDAD , MORRONDO PATROCINIO , DÍEZ-BAÑOS PABLO
Published: April 2010

Faecal specimens from diarrhoeic pre-weaned calves (n=61) and lambs (n=127) collected over a 1-year period (2008–2009) at 27 cattle and 28 sheep farms in Galicia (NW Spain) were examined for the presence of Cryptosporidium oocysts and positive specimens were selected for molecular examination. Overall, 30 calves (49·2%) and 39 lambs (30·7%) tested positive for Cryptosporidium by microscopy. PCR products of the SSU rRNA locus were obtained for 27 Cryptosporidium positive calf isolates and 23 lamb isolates. Restriction analyses generated profiles of C. parvum in all isolates except for 9 lamb specimens from 5 farms that yielded banding patterns and sequences indicative of the Cryptosporidium cervine genotype. Sequence analyses of the glycoprotein (GP60) gene revealed that all but 1 C. parvum isolate from calves belonged to the subtype IIaA15G2R1 and 1 isolate was identified as the novel subtype IIaA13G1R1. Two different subtypes were identified in sheep flocks including IIaA16G3R1, which was seen in 7 lamb isolates from a single farm and subtype IIaA15G2R1, identified in 3 isolates from 2 farms. These findings suggest a limited genetic diversity within C. parvum in ruminant livestock from this geographical area, although both calves and lambs should be considered as a reservoir for zoonotic subtypes.
Emerging trends in the diagnosis of Human African Trypanosomiasis
Authors: RADWANSKA MAGDALENA
Published: April 2010

Human African trypanosomiasis (HAT) or sleeping sickness is caused by protozoan parasitesTrypanosoma brucei gambienseandT. b. rhodesiense. Despite the enormous technological progress in molecular parasitology in recent years, the diagnosis of HAT is still problematic due to the lack of specific tools. To date, there are two realities when it comes to HAT; the first one being the world of modern experimental laboratories, equipped with the latest state-of-the-art technology, and the second being the world of HAT diagnosis, where the latest semi-commercial test was introduced 30 years ago (Magnuset al.1978). Hence, it appears that the lack of progress in HAT diagnosis is not primarily due to a lack of scientific interest or a lack of research funds, but mainly results from the many obstacles encountered in the translation of basic research into field-applicable diagnostics. This review will provide an overview of current diagnostic methods and highlight specific difficulties in solving the shortcomings of these methods. Future perspectives for accurate, robust, affordable diagnostics will be discussed as well.
Relativistic self-distortion of a laser pulse and ponderomotive acceleration of electrons in an axially inhomogeneous plasma
Authors: Singh Rohtash , Sharma A.K. , Tripathi V.K.
Published: April 2010

Relativistic self distortion of a Gaussian laser pulse in inhomogeneous plasma in one dimension is investigated. The relativistic mass effect causes different portions of the pulse to travel with different group velocities leading to the steepening of the pulse front and broadening of the rear. This asymmetry created in the pulse shape gives rise to stronger ponderomotive force on electrons at the front and weaker at the rear. The fast moving electrons under this force are shown to have very significant net energy gain. The energy gain increases with the density scale-length and then saturates.
Alcohol consumption as a risk factor for pneumonia: a systematic review and meta-analysis
Authors: SAMOKHVALOV A. V. , IRVING H. M. , REHM J.
Published: April 2010

The aim of this study was to quantify the association between alcohol consumption and incidence of pneumonia and to examine possible pathways. This was done by a systematic review and meta-analyses on the dose–response relationship between alcohol consumption or alcohol-use disorders and the incidence of community-acquired pneumonia (CAP). The relative risk (RR) of CAP increased monotonically with increasing alcohol consumption. Individuals consuming 24, 60, and 120 g of pure alcohol daily demonstrated RRs for incident CAP of 1·12 (95% CI 1·02–1·23), 1·33 (95% CI 1·06–1·67) and 1·76 (95% CI 1·13–2·77), respectively, relative to non-drinkers. Clinically defined alcohol-use disorders were associated with an eightfold increased risk of CAP (RR 8·22, 95% CI 4·85–13·95). In conclusion, alcohol was found to be a risk factor for pneumonia with a clear statistical association, and a monotonic dose–response relationship.
Assessing Therapy-Relevant Cognitive Capacities in Young People: Development and Psychometric Evaluation of the Self-Reflection and Insight Scale for Youth
Authors: Sauter Floor M. , Heyne David , Blöte Anke W. , van Widenfelt Brigit M. , Westenberg P. Michiel
Published: April 2010

Background: The effectiveness of cognitive-behaviour therapy with young people may be influenced by a young person's capacity for self-reflection and insight. Clinicians who assess clients' proficiencies in these cognitive capacities can better tailor cognitive and behavioural techniques to the client, facilitating engagement and enhancing treatment outcome. It is therefore important that sound instruments for assessing self-reflection and insight in young people are available. Aims: The aim of the current study was to translate and adapt the Self-Reflection and Insight Scale (SRIS) for use with a child and adolescent population (Study 1), and to evaluate the psychometric properties of the resulting measure, the Self-Reflection and Insight Scale for Youth (SRIS-Y; Study 2). Method: In Study 1 (n = 145), the comprehensibility of the SRIS-Y was assessed in a community sample of children and adolescents. Study 2 (n = 215) then explored the reliability and structural, convergent, and divergent validity of the SRIS-Y. Results: The SRIS-Y was found to be comprehensible to young people, and had good reliability and structural validity. Conclusions: It appears that the SRIS-Y is a sound instrument for assessing therapy-relevant cognitive capacities in young people, of potential benefit in both research and clinical contexts. Future research foci include the predictive validity of the instrument.
Mental motor imagery and chronic pain: The foot laterality task
Authors: COSLETT H. BRANCH , MEDINA JARED , KLIOT DASHA , BURKEY ADAM
Published: April 2010

Several lines of evidence suggest that mental motor imagery is subserved by the same cognitive operations and brain structures that underlie action. Additionally, motor imagery is informed by the anticipated sensory consequences of action, including pain. We reasoned that motor imagery could provide a useful measure of chronic leg or foot pain. Forty subjects with leg pain (19 bilateral, 11 right, and 10 left leg pain), 42 subjects with chronic pain not involving the legs, and 38 controls were shown 12 different line drawings of the right or left foot and asked to indicate which foot was depicted. Previous work suggests that subjects perform this task by mentally rotating their foot to match the visually presented stimulus. All groups of subjects were slower and less accurate with stimuli that required a greater degree of mental rotation of their foot. Subjects with leg pain were both slower and less accurate than normal and pain control subjects in responding to drawings of a painful extremity. Furthermore, subjects with leg pain exhibited a significantly greater decrement in performance for stimuli that required larger amplitude mental rotations. These data suggest that motor imagery may provide important insights into the nature of the pain experience. (JINS, 2010, 16, 603–612.)
Meaning and Mechanism in Psychotherapy and General Psychiatry
Authors: Holmes Jeremy
Published: April 2010

On New year's Eve 1992 a man suffering from schizophrenia climbed into a lions' cage at the London Zoo and was badly mauled. This event provoked a full-scale moral panic among the media and government, the tragedy seeming to violate many of the comfortable myths about progress in psychiatry, echoing the impact of the civil war in former Yugoslavia which had shattered the hope of an era of unbroken European peace following the end of the cold war. Whatever we may wish in reality the lion does not lie down with the lamb. Daniel the visionary, the interpreter of dreams, the one who asserted that his God, the God of angels and saints with power over man and beasts would eventually endure, while all earthly kings were found wanting, emerged from the lions’ den unscathed—but secular, psychiatric, suffering, decarcer-ated, visionless, late-twentieth-century man does not.
Mental Disorder, Illness and Biological Disfunction
Authors: Papineau David
Published: April 2010

This paper will be about the relationship between mental disorder and physical disorder. I shall also be concerned with the connection between these notions and the notion of ‘illness’.
Personal Identity and Psychiatric Illness
Authors: Hope Tony
Published: April 2010

This article centres around two somewhat contrasting case histories: one involving a person with dementia; the other a person with mild mania.
Dangerousness and Mental Disorder
Authors: Walker Nigel
Published: April 2010

Unlike topics such as criminal responsibility, dangerousness has only recently begun to interest philosophically minded penologists. The most likely explanation is that until the middle of this century the periods for which people who had done serious harm to others were incarcerated in the UK so long that when they were released their age or condition or circumstances made them unlikely to repeat their crimes. It was only when pressure of resources—in plain terms overcrowded prisons and mental hospitals—forced the shortening of these periods that it became politically necessary to worry about the possible dangerousness of really substantial numbers of prisoners and patients who became eligible for release. The problem was not entirely new. A few lifers, for example, had been set free each year, under licences which lasted for the rest of their lives; and the Special Hospitals which housed the violent insane had discharged carefully selected inmates, also under supervision. But by the late 1960s the introduction of parole, the Mental Health Act and the abolition of capital punishment had greatly increased the number of cases in which the problem of dangerousness had to be faced, and difficult decisions had to be taken.
Problems with the Doctrine of Consent
Authors: Devereux J. A.
Published: April 2010

‘Law’ said Mr Justice Windeyer of the High Court of Australia, ‘marches with science, but to the rear, and limping a little’. Nowhere is this limping more apparent than in respect of the attempts to keep up with medical science. The media is full of reports of the use of fetal ova to create new life, of the transplant of animal parts into human bodies, of tests involving the consumption of radioactive materials by human subjects. The law's response to these problems has been notable most often by its absence. To some extent, the failure of the law to come to grips with developments is not entirely its own fault. Sometimes the advances made possible by science can only be forseen by those with a scientific background. At other times, however, the law fails by not being flexible enough to be able to create new categories of legal obligations. It tries instead to pigeon-hole radically new ideas within centuries-old categorisations. As anyone who has had experience with packing a large number of outsized objects into a too small suitcase will tell you, squeezing things into inappropriately shaped containers takes time. This is one of the problems apparent in the doctrine of consent; the area of law which attempts to regulate the provision of medical services by a practitioner to a patient.
Introduction: Thought as Language
Authors: Preston John
Published: April 2010

Western philosophy has a long-standing interest in the relationship between thought and language. This is not least because language use and our mental capacities are so central to our human self-conception, as well as to the ways in which we have tried to think about other beings. Retrospectively, it is possible to identify certain broad traditions in the philosophical study of thought and language, traditions which also have their representatives in psychology and linguistics. In this introduction I shall focus on one such tradition, the one sometimes known as ‘lingualism ’, in so far as it bears on the papers brought together in this volume.
Seeing through Language
Authors: Davidson Donald
Published: April 2010

We see the world through language; but how should we understand this metaphor? Is language a medium that simply reproduces for the mind, or accurately records, what is out there? Or is it so dense there is no telling what the world is really like? Perhaps language is somewhere in between, a translucent material, so that the world bears the tint and focus of the particular language we speak.
‘The only sure sign …’: Thought and Language in Descartes
Authors: Cottingham John
Published: April 2010

Some people like to think that the modern discipline of philosophy has little if anything to learn from the history of the subject, but in reality the philosophical inquiries of each generation always take shape against the background of an implicit dialogue with the actual or imagined ideas of past thinkers. Many of our current debates on the relationship between thought and language bear the imprint of what the ‘father of modern philosophy’ said, or is supposed to have said.
Words and Pictures
Authors: Hyman John
Published: April 2010

Pictures have always played a prominent role in philosophical speculation about the mind, but the concept of a picture has itself been the object of philosophical scrutiny only intermittently. As a matter of fact, it was studied most intensively in the course of a theological controversy in the Eastern Roman Empire, during the eighth century - which is a sufficient indication of its marginal place in the history of philosophy. Perhaps this is because pictures have never produced in us the theoretical paralysis which Augustine famously associated with time, but have on the contrary generally seemed too unproblematic to deserve much time from philosophers. Even today, after several decades of accumulating theory, philosophers with no stake in the matter are often impervious to its charm. I feel some sympathy for this attitude, because the task of explaining the nature of depiction is, I believe, one which calls for the refinement rather than refutation of our first thoughts about it. But a precise understanding of depiction is both a necessary prolegomenon to a significant part of aesthetics, and a useful prophylactic against confusion in the theory of the imagination. Besides, there is also the pleasure of the chase, which J. L. Austin nonchalantly appealed to many years before the Research Assessment Exercise was inaugurated.
The Explanation of Cognition
Authors: Searle John R.
Published: April 2010

What sorts of systematic explanations should we and can we seek in cognitive science for perception, language comprehension, rational action and other forms of cognition? In broad outline I think the answer is reasonably clear: We are looking forcausal explanations, and our subject matter iscertain functionsof a biological organ, the human and animal brain.
Philosophy, Thought and Language
Authors: Glock Hans-Johann
Published: April 2010

One of the most striking features of twentieth-century philosophy has been its obsession with language. For the most part, this phenomenon is greeted with hostile incredulity by external observers. Surely, they say, if philosophy is the profound and fundamental discipline which it has purported to be for more than two millennia, it must deal with something more serious than mere words, namely the things they stand for, and ultimately the essence of reality or of the human mind (Gellner 1959 provides an amusing, if unsophisticated, example.)
Talking to Cats, Rats and Bats
Authors: Wilkes K. V.
Published: April 2010

This paper tries to argue that at least some alluring, trendy or fashionable problems to do with thought and language — several of which are discussed in this volume — are in fact alluring, trendy or fashionable red herrings or cul-de-sacs. I shall primarily be concerned with the ascription of thought and intelligence to non-language-users; but,en routeto that, will need to brood over our ascriptions of such terms quite generally.
Just war
Authors: Denyer Nicholas
Published: April 2010

The innocent are immune. We must never, that is, make the object of any violent attack those who bear no responsibility for doing wrong to others; and only with grave reason and in extreme circumstances should we be prepared to cause them any incidental harm as we press home a violent attack against those who are its legitimate objects. This principle of the immunity of the innocent seems almost self-evidently true. This is not to say that the principle is incapable of further development and articulation, unsusceptible of marginal qualification, or underivable from deeper principles. It does however mean that any moral theory which denies this principle altogether will be something that only a fool or a knave could accept.
Presentism, Ontology and Temporal Experience
Authors: Oaklander L. Nathan
Published: April 2010

In a recent article, ‘Tensed Time and Our Differential Experience of the Past and Future,’ William Lane Craig (1999a) attempts to resuscitate A. N. Prior's (1959) ‘Thank Goodness’ argument against the B-theory by combining it with Plantinga's (1983) views about basic beliefs. In essence Craig's view is that since there is a universal experience and belief in the objectivity of tense and the reality of becoming, (that he identifies with ‘the presentist metaphysic’) ‘this belief constitutes an intrinsic defeater-defeater which overwhelms the objections brought against it.’ (1999a, 519) An intrinsic defeater-defeater is a belief that enjoys such warrant for us that it simply overwhelms the defeaters brought against it without specifically rebutting or undercutting them. Thus, Craig claims that an effete philosophical argument like McTaggart's paradox is nothing more than ‘an engaging and recalcitrant brain teaser whose conclusion nobody really takes seriously.’ (1999a, 532) It is difficult to reconcile this statement with Craig's own writings elsewhere. For Craig has vigorously argued in at least two other articles that 'hybrid A-B theorists like McCall, Schlesinger, and Smith [who give ontological status to both A-properties and B-relations] are in deep trouble’ (1998, 127) since they are all effectively refuted by McTaggart's Paradox (cf. Craig 1997). It is not Craig's inconsistency regarding the significance of McTaggart conundrum that I want to draw attention to, however. Rather I wish to raise a different issue.
A Presentist's Refutation of Mellor's McTaggart
Authors: Percival Philip
Published: April 2010

For twenty years, D. H. Mellor has promoted an influential defence of a view of time he first called the ‘tenseless’ view, but now associates with what he calls the ‘B-theory.’ It is his defence of this view, not the view itself, which is generally taken to be novel. It is organized around a forcefully presented attack on rival views which he claims to be a development of McTaggart's celebrated argument that the ‘A-series’ is contradictory. I will call this attack ‘Mellor's McTaggart.’ Although it has received much critical attention, it has not been well understood. For one thing, it has changed over the years in a way that is little appreciated. Whereas Mellor's (1981) original version amounts to a dilemma each horn of which contains a single strand of argument, later statements (1986, 1998) of the first horn contain a second strand of argument unannounced. I shall be concerned to disentangle these strands. I shall also show them to have been largely anticipated by Gareth Evans (1979). However, my main aim is not the clarification of Mellor's McTaggart, but its refutation. I shall show that there is a rival to Mellor's view of time against which the first horn of the dilemma begs the question both as originally presented, and as supplemented. This rival is a ‘Priorean’ version of the ‘presentist’ doctrine that only what is present exists. Although Prior himself gave McTaggart's own argument short shrift, in refuting Mellor's development of it I do not merely resurrect Prior's moves. Mellor's McTaggart introduces specifically semantic considerations. It focuses not as McTaggart did on presentness and futurity etc., but on the truth-values of tokens of propositions in which presentness and futurity etc. are (said to be) ascribed. Consequently, its refutation requires an answer, from the perspective of a presentist metaphysics, to a question which came to the fore only after Prior's death. The question is this: How should semantic theory be developed in the light of the need for a theory of linguistic understanding? Though Evans (1979) flirted with the issue of how this question should be answered from a presentist perspective, the answer he articulates is wrong. I shall do no more than sketch the correct answer. That is all a refutation of Mellor's McTaggart requires.
Mc Taggart and the Truth about Time
Authors: Dyke Heather
Published: April 2010

McTaggart famously argued that time is unreal. Today, almost no one agrees with his conclusion.1 But his argument remains thelocus classicusfor both the A–theory and the B-theory of time. I want to show how McTaggart's argument provided the impetus for both of these opposing views of the nature of time. I will also present and defend what I take to be the correct view of the nature of time.
Time Travel and Modern Physics
Authors: Arntzenius Frank , Maudlin Tim
Published: April 2010

Time travel has been a staple of science fiction. With the advent of general relativity it has been entertained by serious physicists. But, especially in the philosophy literature, there have been arguments that time travel is inherently paradoxical. The most famous paradox is the grandfather paradox: you travel back in time and kill your grandfather, thereby preventing your own existence. To avoid inconsistency some circumstance will have to occur which makes you fail in this attempt to kill your grandfather. Doesn't this require some implausible constraint on otherwise unrelated circumstances? We examine such worries in the context of modern physics.
Freedom from the Inside Out
Authors: Hoefer Carl
Published: April 2010

Since the death of strong reductionism, philosophers of science have expanded the horizons of their understandings of the physical, mental, and social worlds, and the complex relations among them. To give one interesting example, John Dupre has endorsed a notion ofdownward causation: ‘higher-level’ events causing events at a ‘lower’ ontological level. For example, my intention to type the letter ‘t’ causes the particular motions experienced by all the atoms in my left forefinger as I type it. The proper explanation of the motions of an atom at the tip of my forefinger primarily involves my intentions, rather than (for example) the immediately preceding motions of other nearby atoms, or any other such particle–level events.
Can Physics Coherently Deny the Reality of Time?
Authors: Healey Richard
Published: April 2010

The conceptual and technical difficulties involved in creating quantum theory of gravity have led some physicists to question, and even in some cases to deny, the reality of time. More surprisingly, this denial has found a sympathetic audience among certain philosophers of physics. What should we make of these wild ideas? Does it even make sense to deny the reality of time? In fact physical science has been chipping away at common sense aspects of time ever since its inception. Section 1 offers a brief survey of the demolition process. Section 2 distinguishes a tempered from an extreme-y l radical form that a denial of time might take, and argues that extreme radicalism is empirically self-refuting. Section 3 begins an investigation of the prospects for tempered radicalism in a timeless theory of quantum gravity.
Energy efficiency in small-scale biointensive organic onion production in Pennsylvania, USA
Authors: Moore Stephen R.
Published: April 2010

Modern agriculture relies heavily on fossil energy for food production. Reducing fossil energy and replacing that energy with renewable energy is critical in attaining a sustainable food system. Hand-scale intensive food production offers a reduction in fossil energy and an increased use of renewable human-based energy. Using biointensive production techniques, onions (Allium cepa) were grown in Pennsylvania, USA. A life-cycle analysis was performed to monitor energy utilization. Individual human labor tasks were evaluated using the factor method. This method accounts for the type and duration of physical activity. The average yield of eight onion varieties utilizing biointensive production in standard-sized beds (9.3 m2;100 ft2) was 160.2 kg. The US average for mechanical onion production is 46.1 kg/9.3 m2 (100 ft2). The energy efficiency ratio, specific energy and energy productivity were 51.5, 0.03 MJ kg−1 and 32.2 kg MJ−1 (MJ=megajoule), respectively. When defined within common boundaries, these three relationships: energy input, energy output and yield productivity allow researchers, farmers and policy-makers to select production systems and/or practices that better manage fossil and renewable energy for food production. Current mechanized agriculture has an energy efficiency ratio of 0.9. With most energy being supplied by fossil fuels. The energy efficiency for biointensive production of onions in our study was over 50 times higher than this value (51.5) and 83% of the total energy required is renewable energy. Biointensive production offers a viable energy use alternative to current production practices and may contribute to a more sustainable food system.
Effects of cultural system (organic and conventional) on growth and fiber quality of two cotton (Gossypium hirsutumL.) varieties
Authors: Bilalis Dimitrios , Patsiali Sotiria , Karkanis Anestis , Konstantas Aristidis , Makris Marios , Efthimiadou Aspasia
Published: April 2010

Organic cotton is a new industrial crop product. Field experiments were conducted to determine the effects of cultural systems and varieties on the growth, fiber quality and yield components of cotton crop (Gossypium hirsutumL.). The experiments, conducted during 2006 and 2007, were laid out in a split plot design with four replicates, two main plots (organic and conventional system) and two sub-plots (cotton varieties: Athena and Campo). There were no significant differences between the organic and conventional system for cotton growth, yield and fiber quality. The results suggest that the soil N released from both the inorganic (80:40:40 kg ha−1N:P2O5:K2O) and organic pool (green manure) were sufficient to maintain good growth. Inferior-quality fiber was produced in the variety. Campo, which had the lowest fiber fineness (micronaire), strength, length and reflection. In addition, this variety had the highest fiber elongation and yellowness. There were no significant differences between varieties as far as uniformity and leaf trash ratio are concerned. A positive correlation was observed between fiber strength and length. However, a negative correlation was found between lint yield and fiber strength.
Impactor Flux on the Pluto-Charon System
Authors: de Elía Gonzalo C. , Di Sisto Romina P. , Brunini Adrián
Published: April 2010

In this work, we study the impactor flux on Pluto and Charon due to the collisional evolution of Plutinos.To do this, we develop a statistical code that includes catastrophic collisions and cratering events, and takes into account the stability and instability zones of the 3:2 mean motion resonance with Neptune. Our results suggest that if 1 Pluto-sized object is in this resonance, the flux of D = 2 km Plutinos on Pluto is ~4–24 percent of the flux of D = 2 km Kuiper Belt projectiles on Pluto. However, with 5 Pluto-sized objects in the resonance, the contribution of the Plutino population to the impactor flux on Pluto may be comparable to that of the Kuiper Belt. As for Charon, if 1 Pluto-sized object is in the 3:2 resonance, the flux of D = 2 km Plutinos is ~10–63 percent of the flux of D = 2 km impactors coming from the Kuiper Belt. However, with 5 Pluto-sized objects, the Plutino population may be a primary source of the impactor flux on Charon. We conclude that it is necessary to specify the Plutino size distribution and the number of Pluto-sized objects in the 3:2 Neptune resonance in order to determine if the Plutino population is a primary source of impactors on the Pluto-Charon system.
Adenine synthesis at Titan atmosphere analog by soft X-rays
Authors: Pilling Sergio , Andrade Diana P. P. , Neto Alvaro C. , Rittner Roberto , de Brito Arnaldo N.
Published: April 2010

In this work, we investigate the possible effects produced by soft X-rays (and secondary electrons) on Titan aerosol analogs in an attempt to simulate some prebiotic photochemistry. The experiments have been performed inside a high vacuum chamber coupled to the soft X-ray spectroscopy beamline at the Brazilian Synchrotron Light Source (LNLS). In-situ sample analysis were performed by a Fourier transform infrared spectrometer. The infrared spectra have presented several organic molecules, including nitriles and aromatic CN compounds. After the irradiation, the brownish-orange organic residue was analyzed ex-situ by gas chromatographic technique revealing the presence of adenine (C5H5N5), one of the constituents of the DNA molecule.
Why Has Religiosity in Poland not Changed since 1989? Five Hypotheses
Authors: Borowik Irena
Published: April 2010

Attitudes about religion in Polish society have scarcely changed since 1989, in spite of radical political and economic transformation over the past 20 years, as survey data show. The question is why? In the following article, the author develops five alternative hypotheses to explain this phenomenon. Each of the hypotheses relates to some function of religion that is relevant in contemporary times. Among other things, historical circumstances, the role of Catholicism as a civil religion, security, and hidden privatization form the context in which one may explain the continuing vitality of religion in Poland.
The Security Council on women in war: between peacebuilding and humanitarian protection
Authors: Tachou-Sipowo Alain-Guy
Published: April 2010

Having established that massive human rights violations in armed conflict constitute a threat to peace and that women are the most severely affected by the scourge of war, the Security Council has since 1999 adopted a number of resolutions intended specifically for this group. These instruments contribute to the development of humanitarian law applicable to women and acknowledge the value of active participation by women in peace efforts. The following article first analyses the foundations on which the Council has been able to assume responsibility for protecting women in situations of armed conflict, and then considers the actual protection it provides. It concludes that the Council has had varying success in this role, pointing out that the thematic and declaratory resolutions on which it is largely based are not binding and therefore, they are relatively effective only as regards their provisions committing United Nations bodies. The author proposes that the Council's role could be better accomplished through situational resolutions than through resolutions declaratory of international law.
Overpressure and earthquake initiated slope failure in the Ursa region, northern Gulf of Mexico
Authors: Stigall Justin , Dugan Brandon
Published: April 2010

We use fluid flow and slope stability models to study the evolution of overpressure and slope stability in the Ursa region, northern Gulf of Mexico. Our predictions match measured overpressures (pressures in excess of hydrostatic) from Integrated Ocean Drilling Program Expedition 308 Site U1324 above 200 m below seafloor (mbsf) but overpredict deeper (200–610 mbsf) overpressures by 0.4–1.1 MPa. Modeled overpressure at Site U1322 matches measurements for the entire section (0–240 mbsf) with exception of the measurement at 240 mbsf. Slope stability models that integrate modeled overpressure, vertical stress, and effective stress during deposition predict slope failure at 61 ka on the eastern end of the region. This failure corresponds to the base of a mass transport deposit that has been interpreted as a retrogressive failure initiated by high overpressure. Overpressure alone could not drive failure of a second mass transport deposit (MTD2) that has its base along the 27 ka horizon. With an earthquake acceleration model coupled with our slope stability model, we predict that horizontal acceleration from a magnitude 5 earthquake within 140 km of the Ursa region at 27 ka would initiate the failure that created MTD2; the same earthquake at 20 ka would have to be within 40 km for failure. This magnitude and maximum rupture distance are consistent with seismicity near the Ursa region. We therefore propose that in some cases, overpressure drives failure on low‐angle slopes; however, earthquakes, even on passive margins, may play a critical role in initiating slope failure in sediments weakened by overpressure.
Link between EMIC waves in a plasmaspheric plume and a detached sub‐auroral proton arc with observations of Cluster and IMAGE satellites
Authors: Yuan Zhigang , Deng Xiaohua , Lin Xi , Pang Ye , Zhou Meng , Décréau P. M. E. , Trotignon J. G. , Lucek E. , Frey H. U. , Wang Jingfang
Published: April 2010

In this paper, we report observations from a Cluster satellite showing that ULF wave occurred in the outer boundary of a plasmaspheric plume on September 4, 2005. The band of observed ULF waves is between the He+ ion gyrofrequency and O+ ion gyrofrequency at the equatorial plane, implying that those ULF waves can be identified as EMIC waves generated by ring current ions in the equatorial plane and strongly affected by rich cold He+ ions in plasmaspheric plumes. During the interval of observed EMIC waves, the footprint of Cluster SC3 lies in a subauroral proton arc observed by the IMAGE FUV instrument, demonstrating that the subauroral proton arc was caused by energetic ring current protons scattered into the loss cone under the Ring Current (RC)‐EMIC interaction in the plasmaspheric plume. Therefore, the paper provides a direct proof that EMIC waves can be generated in the plasmaspheric plume and scatter RC ions to cause subauroral proton arcs.
Pacific Ocean origin for the 2009 Indian summer monsoon failure
Authors: Ratnam J. Venkata , Behera Swadhin K. , Masumoto Y. , Takahashi K. , Yamagata T.
Published: April 2010

The Indian subcontinent suffered from a severe drought during the summer monsoon season of 2009 when El Niño‐like conditions evolved in the Pacific. The warm sea surface temperature (SST) anomalies in this season were seen throughout the tropical Pacific and over subtropical northwest Pacific. Since the atmospheric heat sources were perturbed somewhat differently in this abnormal El Niño year, we have carried out three different sensitivity experiments using an Atmospheric General Circulation Model (AGCM) to understand the associated teleconnection. Experiments are carried out by specifying observed daily SST anomalies over the central Pacific, the eastern Pacific and the subtropical Pacific while prescribing the climatological SST elsewhere. The model results have shown that the warming in the central Pacific, resembling the recently identified El Niño Modoki condition, modified the regional Walker circulation over the tropical and subtropical Pacific so as to cause subsidence over the Indian subcontinent.
Recent Developments in Asymmetric Organocatalysis
Authors: Pellissier Helene
Published: April 2010

The aim of this book is to cover the very recent developments in asymmetric organocatalysis, focussing on those published since the beginning of 2008. The last decade has witnessed an explosive growth in the field of asymmetric organocatalysis with an impressive amount of new catalysts, novel methodologies, and applications in numerous reaction types, such as nucleophilic substitutions, addition reactions, as well as cycloadditions, oxidations, reductions, kinetic resolutions, and miscellaneous reactions. This very diverse and intensely developing field is too wide to cover in a single review. The timeliness of the book together with the expected impact is excellent, since nowadays asymmetric organocatalysis is arguably the most intensively developed field in organic chemistry. The book is designed to meet the demands of a postgraduate textbook,containing case studies and Q&A sections, as well as a practical book filled with facts and data useful as a working tool for the practitioner. The book is divided into ten sections, dealing successively with nucleophilic additions to electron-deficient C=C double bonds, nucleophilic additions to C=O double bonds, nucleophilic additions to C=N double bonds, nucleophilic additions to unsaturated nitrogen, nucleophilic substitutions at aliphatic carbon, cycloaddition reactions, oxidations, reductions, kinetic resolutions and desymmetrisations, and miscellaneous reactions.
Engineering mammalian cells in bioprocessing – current achievements and future perspectives
Authors: Lim Yiping , Wong Niki S. C. , Lee Yih Yean , Ku Sebastian C. Y. , Wong Danny C. F. , Yap Miranda G. S.
Published: April 2010

Over the past 20 years, we have seen significant improvements in product titres from 50 mg/l to 5–10 g/l, a more than 100‐fold increase. The main methods that have been employed to achieve this increase in product titre have been through the manipulation of culture media and process control strategies, such as the optimization of fed‐batch processes. An alternative means to increase productivity has been through the engineering of host cells by altering cellular processes. Recombinant DNA technology has been used to over‐express or suppress specific genes to endow particular phenotypes. Cellular processes that have been altered in host cells include metabolism, cell cycle, protein secretion and apoptosis. Cell engineering has also been employed to improve post‐translational modifications such as glycosylation. In this article, an overview of the main cell engineering strategies previously employed and the impact of these strategies are presented. Many of these strategies focus on engineering cell lines with more efficient carbon metabolism towards reducing waste metabolites, achieving a biphasic production system by engineering cell cycle control, increasing protein secretion by targeting specific endoplasmic reticulum stress chaperones, delaying cell death by targeting anti‐apoptosis genes, and engineering glycosylation by enhancing recombinant protein sialylation and antibody glycosylation. Future perspectives for host cell engineering, and possible areas of research, are also discussed in this review.
Tracing molecular electronic excitation dynamics in real time and space
Authors: Dutoi Anthony D. , Cederbaum Lorenz S. , Wormit Michael , Starcke Jan Hendrik , Dreuw Andreas
Published: April 2010

We present a method for studying the movement of electrons and energy within and between electronically excited molecules. The dynamically changing state is a many-electron wavepacket, for which we numerically integrate the Schrödinger equation using the ADC(2) effective Hamiltonian for the particle-hole propagator. We develop the tools necessary for following the separate motions of the particles and holes. Total particle and hole densities can be used to give an overview of the dynamics, which can be atomically decomposed in a Mulliken fashion, or individual particle and hole states give a more detailed look at the structure of an excitation. We apply our model to a neon chain, as an illustrative example, projecting an excited eigenstate of an isolated atom onto the coupled system as the initial state. In addition to demonstrating our propagation and analysis machinery, the results show a dramatic difference in excitation-energy transfer rates as a consequence of initial polarization. Furthermore, already in a system with three constituents, an important aspect of multiple coupled systems appears, in that one absorbing system essentially shields another, changing the effective sitewise coupling parameters.