bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding the impact of five major determinants of health (genetics, biology, behavior, psychology, society/environment) on type 2 diabetes in U.S. Hispanic/Latino families: Mil Familias - a cohort study
Authors: Morales Jessikah , Glantz Namino , Larez Arianna , Bevier Wendy , Conneely Mary , Fan Ludi , Reed Beverly , Alatorre Carlos , Paczkowski Rosirene , Ahmed Tamim , Mackenzie Andrew , Duncan Ian , Kerr David
Published: January 2020

Background

In the United States (U.S.), the prevalence of both diagnosed and undiagnosed type 2 diabetes (T2D) is nearly twice as high among Mexican-origin Hispanic/Latino adults compared to non-Hispanic Whites. Rates of diabetes-related complications, e.g., acute stroke and end-stage renal disease, are also higher among Hispanic/Latino adults compared to their non-Hispanic/Latino White counterparts. Beyond genetic and biological factors, it is now recognized that sociocultural influences are also important factors in determining risk for T2D and the associated complications. These influences include ethnicity, acculturation, residence, education, and economic status. The primary objective of this study is to determine the influence of the 5 major determinants of human health (genetics, biology, behavior, psychology, society/environment) on the burden of T2D for Latino families. To achieve this objective, Mil Familias (www.milfamilias.sansum.org/) is establishing an observational cohort of 1000 Latino families, with at least one family member living with T2D.

Methods

Specially trained, bilingual Latino/a community health workers (Especialistas) recruit participant families and conduct research activities. Each individual family member will contribute data annually on over 100 different variables relating to their genetics, biology, psychology, behavior, and society/environment, creating a Latino-focused biobank (“Living Information Bank”). This observational cohort study is cross-sectional and longitudinal. Participants are divided into 4 groups: adults age ≥ 18 years with and without T2D, and children age ≥ 7 and < 18 years with and without T2D. Study activities take place through encounters between families and their Especialista. Encounters include screening/enrollment, informed consent, health promotion assessment, laboratory tests, questionnaires, physical activity monitoring, and reflection.

Discussion

By creating and providing the framework for the Cohort Establishment study, we intend to inform new approaches regarding equity and excellence in diabetes research and care. We will examine the complex set of factors that contribute to the burden of diabetes in Latino families and assess if cardio-metabolic disease risks go beyond the traditional biological and genetic factors. Breaking the code on the interplay of cardio-metabolic risk factors may help not only this fast growing segment of the U.S. population, but also other high-risk populations.

Trial registration

Study retrospectively registered at ClinicalTrials.gov (NCT03830840), 2/5/2019 (enrollment began 2/1/2019).
Adaptation and validation of the PEDSQL™ oral health scale for toddlers in Chilean population
Authors: Atala-Acevedo Claudia , Zaror Carlos , Espinoza-Espinoza Gerardo , Muñoz-Millán Patricia , Muñoz Sergio , Martínez-Zapata María José , Ferrer Montse
Published: January 2020

Background

The Pediatric Quality of Life Inventory™ (PedsQL™) Oral Health Scale was developed to measure oral health-related quality of life (OHRQoL). The aim of this study was to cross-culturally adapt the parent-reported version for toddlers of PedsQL™ Oral Health Scale into Spanish and to assess the acceptability, reliability and validity of this version in Chilean preschool population.

Methods

The PedsQL™ Oral Health Scale for toddlers was cross-culturally adapted for the Spanish language using the recommended standards. To assess metric properties, a cross-sectional study was carried out with 301 children aged 2 to 5 years in Carahue, Chile. Chilean versions of the PedsQL™ Oral Health Scale, PedsQL™ 4.0 Generic Core Scales, and Early Childhood Oral Health Impact Scale (ECOHIS) were completed by the children’s parents. Dental caries, malocclusion and dental trauma were examined by trained dentists. The PedsQL™ Oral Health Scale was administrated a second time 14–21 days after. The reliability of the scale was verified by analysis of internal consistency (Cronbach’s alpha) and reproducibility (Intraclass correlation coefficient – ICC). The validity of the construct was assessed by confirmatory factor analysis and known groups method. The convergent validity was assessed by calculating the Spearman’s correlation with the ECOHIS questionnaire.

Results

The PedsQL™ Oral Health Scale demonstrated good reliability, with Cronbach’s alpha coefficient of 0.79 and ICC of 0.85. A moderate-to-strong correlation was found between the PedsQL™ Oral Health Scale and the ECOHIS questionnaire (− 0.64); the PedsQL™ Oral Health Scale score was lower in children with poor than those with excellent/very good oral health (median 100 vs 85, p < 0.001); it also was lower in children with caries than in those caries-free (median 100 vs 90, p < 0.001). No statistically significant differences were found among groups according to malocclusion and traumatic dental injuries.

Conclusions

The PedsQL™ Oral Health Scale for toddlers in Spanish showed to be equivalent to the original version, and its psychometric properties were satisfactory for application in a Chilean pre-school population.
Prevalence of primary dysmenorrhea, its intensity, impact and associated factors among female students’ at Gondar town preparatory school, Northwest Ethiopia
Authors: Azagew Abere Woretaw , Kassie Destaye Guadie , Walle Tarkie Abebe
Published: January 2020

Background

Primary dysmenorrhea is defined as a crampy pain in the lower abdomen before or during the menstrual period in the absence of any pelvic pathology. It is the leading motherhood problem worldwide but there is limited evidence on the prevalence of primary dysmenorrhea in the study area as well in Ethiopia. Researching primary dysmenorrhea helps to focus on the treatment plan. The study aimed to assess the prevalence, intensity, impact, and associated factors of primary dysmenorrhea among female students at Gondar town preparatory school.

Methods

A cross-sectional study design conducted among female students at Gondar town Preparatory School from May 1–10/2017. A total of 459 study participants were used. A simple random sampling technique was used to select study participants. A self-administered structured questionnaire was employed. Epi Info version 7 and SPSS version 20 were used for data entry and analysis respectively. A binary logistic regression model was computed. Variables having a p-value < 0.05 in the multivariate logistic regression model were considered as statistically significant.

Results

A total of 459 female students participated in the study with a response rate of 96.29%. The prevalence of primary dysmenorrhea among female students was found to be 64.7% (95% CI; 60.2–69.2%). Around 61% reported moderate intensity of menstrual pain and 50.7% complain about lower abdominal pain. Sixty-five percent of study participants reported that absenteeism from school was the impact of menstrual pain. Having irregular monthly menstrual cycle (AOR = 1.70, 95% CI; 1.02, 2.84) and positive family history of dysmenorrhea (AOR = 5.19, 95% CI: 3.21, 8.37) were significantly associated with primary dysmenorrhea.

Conclusions

The prevalence of primary dysmenorrhea was found to be high. Having an irregular monthly menstrual cycle and a positive family history of dysmenorrhea were determinants of primary dysmenorrhea.
Adverse drug reactions in primary care: a scoping review
Authors: Khalil H. , Huang C.
Published: January 2020

Background

Medication-related adverse events, or adverse drug reactions (ADRs) are harmful events caused by medication. ADRs could have profound effects on the patients’ quality of life, as well as creating an increased burden on the healthcare system. ADRs are one of the rising causes of morbidity and mortality internationally, and will continue to be a significant public health issue with the increased complexity in medication, to treat various diseases in an aging society. This scoping review aims to provide a detailed map of the most common adverse drug reactions experienced in primary healthcare setting, the drug classes that are most commonly associated with different levels/types of adverse drug reactions, causes of ADRs, their prevalence and consequences of experiencing ADRs.

Methods

We systematically reviewed electronic databases Ovid MEDLINE, Embase, CINAHL Plus, Cochrane Central Register of Controlled Trials, PsycINFO and Scopus. In addition, the National Patient Safety Foundation Bibliography and the Agency for Health Care Research and Quality and Patient Safety Net Bibliography were searched. Studies published from 1990 onwards until December 7, 2018 were included as the incidence of reporting drug reactions were not prevalent before 1990. We only include studies published in English.

Results

The final search yielded a total of 19 citations for inclusion published over a 15-year period that primarily focused on investigating the different types of adverse drug reactions in primary healthcare. The most causes of adverse events were related to drug related and allergies. Idiosyncratic adverse reactions were not very commonly reported. The most common adverse drug reactions reported in the studies included in this review were those that are associated with the central nervous system, gastrointestinal system and cardiovascular system. Several classes of medications were reported to be associated with adverse events.

Conclusion

This scoping review identified that the most causes of ADRs were drug related and due to allergies. Idiosyncratic adverse reactions were not very commonly reported in the literature. This is mainly because it is hard to predict and these reactions are not associated with drug doses or routes of administration. The most common ADRs reported in the studies included in this review were those that are associated with the central nervous system, gastrointestinal system and cardiovascular system. Several classes of medications were reported to be associated with ADRs.
Barriers and facilitators to healthcare access for children with disabilities in low and middle income sub-Saharan African countries: a scoping review
Authors: Adugna Molalign B. , Nabbouh Fatima , Shehata Selvia , Ghahari Setareh
Published: January 2020

Background

Children with disabilities (CwDs) make up around 150 million of the billion people with disabilities in the world. The Sub-Saharan African countries have a large number of CwDs who have limited access to healthcare and rehabilitation care. This, combined with chronic poverty, low education, and inadequately trained healthcare professionals, substantially lowers these children’s quality of life. The main objective of this scoping review was to discover the barriers and facilitators to healthcare access for CwDs in selected low to middle income Sub-Saharan African countries. As African countries significantly vary in socioeconomic status, we only focused on countries in Sub-Saharan Africa who allocated less than $50/person to healthcare.

Methods

A broad and iterative search strategy using multiple sources and databases including CINAHL, Medline, Global Health, and Embase were utilized. Using a comprehensive search strategy, 704 articles were generated. After removal of the duplicates, 466 of them were screened based on the study inclusion and exclusion criteria. After iterative reading and screening of these articles, a final 15 articles were included in this review.

Results

This scoping review shows that CwDs in the selected Sub-Saharan African countries face major barriers including stigma and negative attitudes, poverty and insufficient resources, inadequate policy implementations, physical inaccessibility, lack of transportation, lack of privacy, and inadequately trained healthcare professionals to deal with disability. Emotional and social support, including peer support for CwDs and caregivers, were identified as facilitators for better access to health services.

Conclusions

There is limited access to healthcare services in the low and middle income Sub-Saharan African countries due to poverty, low education, inadequate healthcare systems, and shortage of healthcare professionals. It is evident that there are socioeconomic, cultural, and physical related impediments that affect CwDs’ and their caregivers’ access to the required healthcare services. Policy development, improved physical accessibility, public disability awareness, and parental support are some of the key facilitators to access healthcare services. The study highlights the importance of revisions to childhood disability and healthcare provisions policy and practice as well as sustainable rehabilitation programs. Further research is required to explore ways to improve experience of accessing health services.
Use of antibiotics and asthma medication for acute lower respiratory tract infections in people with and without asthma: retrospective cohort study
Authors: Denholm Rachel , van der Werf Esther T. , Hay Alastair D.
Published: January 2020

Background

Antibiotics are overused in patients with acute lower respiratory tract infections (ALRTIs), but less is known about their use in patients with asthma, or the use of asthma medication for ALRTI in patients without asthma. Our aim was to describe the frequency, variation and drivers in antibiotic and asthma medication prescribing for ALRTI in adults with and without asthma in primary care.

Methods

A retrospective cohort analysis of patients aged ≥12 years, diagnosed with an ALRTI in primary care in 2014–15 was conducted using data from the Clinical Practice Research Datalink. Current asthma status, asthma medication and oral antibiotic use within 3 days of ALRTI infection was determined. Treatment frequency was calculated by asthma status. Mixed-effect regression models were used to explore between-practice variation and treatment determinants.

Results

There were 127,976 ALRTIs reported among 110,418 patients during the study period, of whom 17,952 (16%) had asthma. Respectively, 81 and 79% of patients with and without asthma received antibiotics, and 41 and 15% asthma medication. There were significant differences in between-practice prescribing for all treatments, with greatest differences seen for oral steroids (odds ratio (OR) 18; 95% CI 7–82 and OR = 94; 33–363, with and without asthma) and asthma medication only (OR 7; 4–18 and OR = 17; 10–33, with and without asthma).

Independent predictors of antibiotic prescribing among patients with asthma included fewer previous ALRTI presentations (≥2 vs. 0 previous ALRTI: OR = 0.25; 0.16–0.39), higher practice (OR = 1.47; 1.35–1.60 per SD) and prior antibiotic prescribing (3+ vs. 1 prescriptions OR = 1.28; 1.04–1.57) and concurrent asthma medication (OR = 1.44; 1.32–1.57). Independent predictors of asthma medication in patients without asthma included higher prior asthma medication prescribing (≥7 vs. 0 prescriptions OR = 2.31; 1.83–2.91) and concurrent antibiotic prescribing (OR = 3.59; 3.22–4.01).

Conclusion

Findings from the study indicate that antibiotics are over-used for ALRTI, irrespective of asthma status, and asthma medication is over-used in patients without asthma, with between-practice variation suggesting considerable clinical uncertainty. Further research is urgently needed to clarify the role of these medications for ALRTI.
The Operative management in Bariatric Acute abdomen (OBA) Survey: long-term complications of bariatric surgery and the emergency surgeon’s point of view
Authors:   the OBA trial supporters, De Simone Belinda , Ansaloni Luca , Sartelli Massimo , Kluger Yoram , Abu-Zidan Fikri M. , Biffl Walter L. , Heyer Arianna , Coccolini Federico , Baiocchi Gian Luca , Catena Fausto
Published: January 2020

Background

The number of bariatric procedures is increasing worldwide. No consensus or guidelines about the emergency management of long-term complications following bariatric surgery are currently available. The aim of this study is to investigate by a web survey how an emergency surgeon approaches this unique group of patients in an emergency medical scenario and to report their personal experience.

Method

An international web survey was sent to 197 emergency surgeons with the aim to collect data about emergency surgeons’ experience in the management of patients admitted in the emergency department for acute abdominal pain after bariatric surgery. The survey was conceived as a questionnaire composed by 26 (multiple choice and open) questions and approved by a steering committee.

Results

One hundred seventeen international emergency surgeons decided to join the project and answered to the web survey with a response rate of 59.39%.

Conclusions

The aim of this WSES web survey was to highlight the current management of patients previously submitted to bariatric surgical procedures by ES.

Emergency surgeons must be mindful of postoperative bariatric surgery complications. CT scan with oral intestinal opacification may be useful in making a diagnosis if carefully interpreted by the radiologist and the surgeon.

In case of inconclusive clinical and radiological findings, when symptoms fail to improve, surgical exploration for bariatric patients presenting acute abdominal pain, by laparoscopy if expertise is available, is mandatory in the first 12–24 h, to have good outcomes and decrease morbidity rate.
Increased neutrophil extracellular traps promote metastasis potential of hepatocellular carcinoma via provoking tumorous inflammatory response
Authors: Yang Lu-Yu , Luo Qin , Lu Lu , Zhu Wen-Wei , Sun Hao-Ting , Wei Ran , Lin Zhi-Fei , Wang Xiang-Yu , Wang Chao-Qun , Lu Ming , Jia Hu-Liang , Chen Jin-Hong , Zhang Ju-Bo , Qin Lun-Xiu
Published: January 2020

Background

The propensity of the activated neutrophils to form extracellular traps (NETs) is demonstrated in multiple inflammatory conditions. In this study, we investigated the roles of NETs in metastasis of hepatocellular carcinoma (HCC) and further explored the underlying mechanism of how NETs affect metastasis as well as the therapeutic value.

Methods

The neutrophils were isolated from the blood of human HCC patients and used to evaluate the formation of NETs. The expression of NET markers was detected in tumor specimens. A LPS-induced NET model was used to investigate the role of NETs on HCC metastasis. RNA-seq was performed to identify the key molecular event triggered by NETs, and their underlying mechanism and therapeutic significance were explored using both in vitro and in vivo assays.

Results

NET formation was enhanced in neutrophils derived from HCC patients, especially those with metastatic HCCs. NETs trapped HCC cells and subsequently induced cell-death resistance and enhanced invasiveness to trigger their metastatic potential, which was mediated by internalization of NETs into trapped HCC cells and activation of Toll-like receptors TLR4/9-COX2 signaling. Inhibition of TLR4/9-COX2 signaling abrogated the NET-aroused metastatic potential. A combination of DNase 1 directly wrecking NETs with anti-inflammation drugs aspirin/hydroxychloroquine effectively reduced HCC metastasis in mice model.

Conclusions

NETs trigger tumorous inflammatory response and fuel HCC metastasis. Targeting NETs rather than neutrophils themselves can be a practice strategy against HCC metastasis.
Food related attention bias modification training for anorexia nervosa and its potential underpinning mechanisms
Authors: Mercado Daniela , Schmidt Ulrike , O’Daly Owen G. , Campbell Iain C. , Werthmann Jessica
Published: January 2020

Treatment outcomes in anorexia nervosa (AN) remain suboptimal, evidencing the need for better and more targeted treatments. Whilst the aetiology of AN is complex, cognitive processes such as attention bias (AB) have been proposed to contribute to maintaining food restriction behaviour. Attention bias modification raining (ABMT) has been investigated in other eating disorders (EDs) such as binge eating disorder (BED) as a means of modifying AB for food and of changing eating behaviour. Promising findings have been reported, but the mechanisms underlying ABMT are poorly understood. We hypothesise that in AN, ABMT has the potential to modify maladaptive eating behaviours related to anxiety around food and eating and propose two mechanistic models; (1) ABMT increases general attentional control (which will improve control over disorder-relevant thoughts) or (2) ABMT promotes stimulus re-evaluation. In this second case, the effects of ABMT might arise via changes in the subjective value of food stimuli (i.e. reward processing) or via habituation, with both resulting in a reduced threat response. Investigating the clinical potential of ABMT in AN holds the promise of a novel, evidence-based adjunctive treatment approach. Importantly, understanding ABMT’s underlying mechanisms will help tailor treatment protocols and improve understanding of the cognitive characteristics of AN and other EDs.
Epidemiology and outcomes of sepsis among hospitalizations with systemic lupus erythematosus admitted to the ICU: a population-based cohort study
Authors: Oud Lavi
Published: January 2020

Background

Sepsis is the most common cause of premature death among patients with systemic lupus erythematosus (SLE) aged ≤ 50 years in the United States, and infection is the most common cause of admission to the ICU among SLE patients. However, there are no population-level data on the patterns of the demand for critical care services among hospitalized septic patients with SLE or the outcomes of those admitted to the ICU.

Methods

We performed a retrospective cohort study, using the Texas Inpatient Public Use Data File, to identify SLE hospitalizations aged ≥ 18 years and the subgroups with sepsis and ICU admission during 2009–2014. The patterns of ICU admission among septic hospitalizations were examined. Logistic regression modeling was used to identify predictors of short-term mortality (defined as hospital death or discharge to hospice) among ICU admissions with sepsis and to estimate the risk-adjusted short-term mortality among ICU admissions with and without sepsis.

Results

Among 94,338 SLE hospitalizations, 17,037 (18.1%) had sepsis and 9409 (55.2%) of the latter were admitted to the ICU. Sepsis accounted for 51.5% of the growth in volume of ICU admissions among SLE hospitalizations during the study period. Among ICU admissions with sepsis, 25.3% were aged ≥ 65 years, 88.6% were female, and 64.4% were non-white minorities. The odds of short-term mortality among septic ICU admissions were increased among those lacking health insurance (adjusted odds ratio 1.40 [95% confidence interval 1.07–1.84]), while being unaffected by gender and race/ethnicity, and remaining unchanged over the study period. On adjusted analyses among ICU admissions, the short-term mortality among those with and without sepsis was 13% (95% CI 12.6–13.3) and 2.7% (95% CI 2.6–2.8), respectively. Sepsis was associated with 63.6% of all short-term mortality events.

Conclusions

Sepsis is a major, incremental driver of the demand for critical care services among SLE hospitalizations. Despite its relatively low mortality, sepsis was associated with most of the short-term deaths among ICU patients with SLE.
Modelling of flowslides and debris avalanches in natural and engineered slopes: a review
Authors: Cuomo Sabatino
Published: January 2020

Background

The landslides of the flow-type are dangerous and also challenging to study. A wide literature has been investigating the principal mechanisms governing each stage in which these phenomena can be ideally subdivided: failure, post-failure and propagation. However, holistic contributions and general overviews are very rare. In addition, a number of numerical methods have been issued and validated so that new chances exist to efficiently model those threats. The paper focuses on two classes of rainfall-induced landslides of the flow-type, namely debris flows and debris avalanches. The principal numerical methods are reviewed for modelling the landslide initiation and propagation and are later used for analyzing a series of benchmark slopes and real case histories which are successfully simulated.

Results

The rainfall from ground surface and water spring from the bedrock are key factors for slope instability. Pore water pressure plays a relevant role also during the propagation stage. The entrainment of further material makes the propagation patterns complex due to lateral spreading and slow-down of the front of flows. It is shown that the used models are capable to provide useful indications even for combined channelized and unchannelized flows.

Conclusions

Notwithstanding the complexity of flow-like landslides and the related challenges in modelling, the understanding and forecasting of such natural hazards is achievable with a satisfactory confidence. Among the key factors, rainfall, pore water pressure and bed entrainment deserves a special attention. Further improvements are expectable as the numerical models are becoming more efficient. Thus, more accurate descriptions of local effects will be possible and also additional mechanisms will be eventually analysed.
Correction to: V Brazilian consensus guidelines for detection of anti-cell autoantibodies on hep-2 cells
Authors: de Melo Cruvinel Wilson , Andrade Luis Eduardo Coelho , von Mühlen Carlos Alberto , Dellavance Alessandra , Ximenes Antônio Carlos , Bichara Carlos David , Bueno Cleonice , Mangueira Cristóvão Luis Pitangueira , Bonfá Eloísa , de Almeida Brito Fabiano , Flumian Fernanda Bull , da Silva Glaucielen Gomes , Rêgo Jozelia , dos Anjos Lisiane Maria Ericoni , Slhessarenko Natasha , Pasoto Sandra Gofinet , Neves Suzane Pretti Figueiredo , Valim Valéria , dos Santos Wilton Silva , Francescantonio Paulo Luiz Carvalho
Published: January 2020

After publication of the original article [1], we were notified that there is a mistake in Fig. 2.
Evaluation of the 12-Gene Molecular Score and the 21-Gene Recurrence Score as Predictors of Response to Neo-adjuvant Chemotherapy in Estrogen Receptor-Positive, HER2-Negative Breast Cancer
Authors: Soliman Hatem , Wagner Susanne , Flake Darl D. , Robson Mark , Schwartzberg Lee , Sharma Priyanka , Magliocco Anthony , Kronenwett Ralf , Lancaster Johnathan M. , Lanchbury Jerry S. , Gutin Alexander , Gradishar William
Published: January 2020

Background

Neo-adjuvant chemotherapy (NaCT) facilitates complete surgical resection in locally advanced breast cancer. Due to its association with improved outcome, complete pathologic response (pCR) to neo-adjuvant treatment has been accepted as a surrogate for long-term outcome in clinical trials of human epidermal growth factor receptor 2 (HER2)-positive, triple-negative, or luminal B breast cancer patients. In contrast, NaCT is effective in only ~ 7–10% of estrogen receptor (ER)-positive, HER2-negative disease. Response biomarkers would enable such patients to be selected for NaCT.

Methods

Two commercially available breast cancer prognostic signatures [12-gene molecular score (MS) and the 21-gene Recurrence Score (RS)] were compared in their ability to predict pCR to NaCT in ER-positive, HER2-negative breast cancer in six public RNA expression microarray data sets. Scores were approximated according to published algorithms and analyzed by logistic regression.

Results

Expression data were available for 764 ER-positive, HER2-negative breast cancer samples, including 59 patients with pCR. The two scores were well correlated. Either score was a significant predictor of pCR (12-gene MS p = 9.4 × 10−5; 21-gene RS p = 0.0041). However, in a model containing both scores, the 12-gene MS remained significant (p = 0.0079), while the 21-gene RS did not (p = 0.79).

Conclusions

In this microarray study, two commercial breast cancer prognostic scores were significant predictors of response to NaCT. In direct comparison, the 12-gene MS outperformed the 21-gene RS as a predictive marker for NaCT. Considering pCR as surrogate for improved survival, these results support the ability of both scores to predict chemotherapy sensitivity.
Peste, uma zoonose esquecida
Authors: Tavares Celso , Leal Nilma Cintra , Sobreira Marise , Almeida Alzira Maria Paiva
Published: January 2020

Objetivo: caracterizar aspectos epidemiológicos e clínicos fundamentais, discutir a metodologia do diagnóstico e tecer recomendações sobre as condutas perante a suspeição de casos de peste. Métodos: revisão bibliográfica e levantamento das internações e mortes por peste registradas no Sistema de Informações Hospitalares do Sistema Único de Saúde. Resultados e conclusões: a existência de diagnósticos equivocados de uma doença potencialmente fatal, além dos registros hipotéticos de internações e mortes, constitui um desafio a ser superado, pois espelha uma situação inaceitável, em que um possível e insólito diagnóstico não é investigado e acumula-se nos sistemas de informação.
DUALIDADE E CONTRADIÇÕES NO PROJETO DE EDUCAÇÃO PROFISSIONAL BRASILEIRO
Authors: Farias Rosane De Abreu
Published: January 2020

O presente trabalho teve por objetivo discutir as contradições da formação profissional brasileira a partir da dualidade estrutural revelada pela relação capital-trabalho e seu reflexo na relação trabalho-educação. Buscou-se demonstrar a partir do estudos de Saviani (2003, 2007), Frigotto (2009) e Kuenzer (1997) como foi construída a dualidade educacional brasileira. Reconstituída a historicidade desse processo, utilizou-se de Rodrigues (1998), Ramos (2011, 2013) e Frigotto, Ciavatta e Ramos (2005) para ressaltar os sentidos de uma formação integrada a partir dos conceitos de Politecnia de Marx e Engels, e de escola Unitária de Gramsci. Assim, da confluência dos estudos de Rodrigues (1998) e Ramos (2013) foram configurados os quatros sentidos da integração da educação profissional ao ensino médio: o etico-político, o filosófico, o epistemológico e o pedagógico, como "travessia" para o ideal de politecnia.
ANÁLISE DA DECISÃO DO SUPERIOR TRIBUNAL DE JUSTIÇA NO HABEAS CORPUS Nº 281.101/SP À LUZ DA PROIBIÇÃO DO BIS IN IDEM.
Authors: Bezerra Heitor Eduardo Cabral , Saboya Keity Mara Ferreira de Souza e
Published: January 2020

Recentemente, o Superior Tribunal de Justiça decidiu que, diante de duplicidade de sentenças penais condenatórias, deve prevalecer a mais benéfica ao acusado, mesmo proferida posteriormente. Todavia, o voto divergente defendeu que a segunda condenação jamais poderia preponderar, em virtude do trânsito em julgado da primeira. O acerto da decisão deve ser analisado à luz do ne bis in idem, destacando-se sua natureza jurídica, seus fundamentos e suas dimensões. Somente assim chegar-se-á a uma conclusão que confira o merecido prestígio  esse postulado, valorizando sua natureza de direito fundamental de defesa, que objetiva proteger o cidadão dos abusos persecutórios do Estado.
PERFIL DOS SUSCITANTES DO INCIDENTE DE RESOLUÇÃO DE DEMANDAS REPETITIVAS - UMA ANÁLISE EMPÍRICA
Authors: Zufelato Camilo , Oliveira Fernando Antônio
Published: January 2020

O objetivo central deste artigo é analisar o perfil dos suscitantes do Incidente de Resolução de Demandas Repetitivas (IRDR), considerando os incidentes suscitados até 15 de junho de 2018, no âmbito dos tribunais estaduais e regionais federais de todo o país, cujos dados foram coletados pelo Observatório Brasileiro de IRDR`s. Além disso, serão feitas reflexões relacionadas aos desdobramentos dos incidentes instaurados pelos diversos tipos de suscitantes, a fim de tentar extrair algumas conclusões e apontamentos sobre os dados analisados, em cotejo com o referencial teórico pertinente à matéria.
Do Debate Processual e Desenvolvimento do Processo: o contraditório como direito fundamental ao justo processo
Authors: Ribeiro Darci Guimarães , Möller Gabriela Samrsla , Dos Santos Paulo Junior Trindade
Published: January 2020

O texto explora formas/possibilidades de o processo civil servir como espaço democrático de participação e construção do direito a partir de uma análise crítica de sua arquitetura (objeto, dispositivo, contraditório), pois a constitucionalização do processo traz ao centro o processo justo, onde o contraditório processual (debate processual) possibilita que o processo seja canal de abertura contextual para o direito e realizando a tutela efetiva. Propõe-se que o contraditório é canal de abertura para se falar em um novo princípio dispositivo, flexibilização da congruência processual e fundamentação pelo objeto do debate processual. O processo civil ganha especial relevo frente a uma sociedade dinâmica e complexa, marcada pela juridicização da vida, que busca no judiciário canal de reivindicação e luta por direitos e esse relevo adquirido principalmente após a constitucionalização do direito exige que institutos que compõe a arquitetura do processo sejam revisitados na busca de um caminho democrático-participativo para a hermenêutica jurídica. A reflexão destaca a importância do contraditório como momento de participação das partes na construção do direito para a proteção dos direitos fundamentais, podendo-se assim começar a se falar em um processo justo.
O WHISTLEBLOWING COMO MEIO DE OBTENÇÃO DE PROVA NO DIREITO PROCESSUAL PENAL BRASILEIRO
Authors: Minahim Maria Auxiliadora De Almeida , Spínola Luíza Moura Costa
Published: January 2020

O canal de denúncias anônimas (whistleblowing) é um mecanismo essencial para garantir o sucesso de um programa de cumprimento normativo (compliance), sendo utilizado com bastante frequência nos Estados Unidos e na Espanha e recomendado por entidades como a Transparência Internacional. Questiona-se como provas obtidas por meio de informações advindas de denúncias anônimas podem ser utilizadas a favor do réu no processamento de crimes econômicos. Conclui-se que, apesar de a legislação brasileira ainda não ter regulamentado a questão das denúncias anônimas, tal meio de obtenção de prova pode ser admitido no processamento de crimes econômicos.
PONTOS DE ENCONTRO E DESENCONTRO ENTRE A LEGITIMAÇÃO EXTRAORDINÁRIA NEGOCIAL E A ASSISTÊNCIA
Authors: Vieira Debora Da Silva , Costa Rosalina Moitta Pinto da , Góes Gisele Santos Fernandes
Published: January 2020

Este trabalho analisa a possibilidade de legitimação extraordinária pela via negocial e seus reflexos no instituto da assistência, modalidade de intervenção de terceiros. Inicia-se a pesquisa com o estudo da teoria dos fatos jurídicos processuais. Após, analisa-se a possibilidade de negociação processual para atribuição da legitimação extraordinária, pautada na cumulação dos artigos 18 e 190 do Código de Processo Civil. Corroborada tal viabilidade, passa-se ao estudo dos pontos de convergência e divergência entre a legitimação extraordinária negocial processual com a assistência, simples e litisconsorcial, concluindo-se que a possibilidade de legitimação extraordinária negocial apresenta pontos de contato nos institutos das assistências.
A NECESSIDADE DE ANÁLISE DOS CRITÉRIOS QUE AUTORIZAM A REDISCUSSÃO DOS PRECEDENTES COMO QUESTÃO PRÉVIA
Authors: Posada Francisco Emilio De Carvalho
Published: January 2020

Diante das inovações trazidas pelo Código de Processo Civil referentes ao sistema de precedentes judiciais, o objetivo deste artigo é discutir a necessidade de que seja tratada como questão prévia a existência ou não de critérios que possibilitem ou autorizem a revisão de um precedente judicial, conferindo-lhe maior grau de estabilidade
Investigation of Relationships among Anxiety, Intolerance of Uncertainty, and Decision Making
Authors: TANTAN ULU Şeyma , YAKA Barış
Published: January 2020

The aim of this research is to investigate the relationships among trait anxiety, intolerance of uncertainty, and decision-making behavior. In this research, a descriptive research design was used. The research was conducted with the participation of volunteer university students who were enrolled in the undergraduate programs at Ege University Faculty of Education. Convenient sampling method was used and the data obtained from 105 participants (43 male and 62 female) were analyzed. Data collection instruments in the research were a Demographic Information Form, Trait Anxiety Inventory, Intolerance of Uncertainty Scale (long form), and Iowa Gambling Task. Correlational analysis was used to analyze the research data. As a result of the analysis, there was no statistically significant relationship between university students’ trait anxiety level and Iowa Gambling Task performance. Also, there was no statistically significant relationship between the students’ intolerance of uncertainty level and Iowa Gambling Task performance. However, it was concluded that there was a significant positive correlation between trait anxiety level and intolerance of uncertainty level of the students. The research findings were discussed in the light of the literature and some recommendations were made for future studies.
ALOCAÇÃO ESPACIAL E ASSOCIAÇÕES GEOGRÁFICAS DAS MICRO E PEQUENAS EMPRESAS NOS SETORES PRODUTIVOS DA MICRORREGIÃO DE IMPERATRIZ-MA, BRASIL
Authors: Saraiva Antonia Francisca da Silva , Andrade Gyllhemberg Nascimento Santiago de , Oliveira Nilton Marques de , Luz Rodolfo Alves da
Published: January 2020

Este artigo analisa a alocação espacial e o grau de associações geográficas das micro e pequenas empresas (MPEs) nos setores produtivos da microrregião de Imperatriz-MA, nos anos de 2008, 2012 e 2016. A metodologia é descritiva com abordagem qualitativa e utilização de dados secundários, retirados da base de dados da Relação Anual de Informações Sociais (RAIS). Foram utilizados o indicador de Quociente Locacional (QL) e o Coeficiente de Associação Geográfica (CAG). Os principais resultados sugerem que Imperatriz e Açailândia possuem um sistema de mercado, comércio e serviços aquecido, sendo polarizadores desta microrregião. O setor da agropecuária é um dos principais segmentos na região e o que mais contribuiu para formação do PIB. Boa parte das MPEs da microregião localiza-se em municípios mais desenvolvidos e com melhor infraestrutura
CONSÓRCIOS INTERMUNICIPAIS DE SAÚDE: ANÁLISE SOB A PERSPECTIVA DA ACCOUNTABILITY E DA TEORIA DA AGÊNCIA NO SETOR PÚBLICO
Authors: Martins Jéssica Natália da Silva , Tavares Bruno , Silva Maysa Alves Correa , Faria Evandro Rodrigues de
Published: January 2020

O objetivo deste artigo foi avaliar se elementos da Teoria da Agência e da Accountability estão presentes nos Protocolos de Intenções dos Consórcios Intermunicipais de Saúde de Minas Gerais. Para a execução da proposta, foi realizada uma Análise de Conteúdo temática e categorial dos Protocolos de Intenções de tais entidades, a partir de categorias de análise criadas (relação de agência, informação transparente, participação, controle e sanção). Os resultados mostraram que nos documentos analisados foram encontrados elementos da Teoria da Agência e da Accountability (Accountability Vertical, Horizontal, Societal e Democrática). Ressaltou-se, no entanto, algumas definições ainda incipientes nos documentos analisados (accountability política e enforcement), que poderiam minimizar/mitigar possíveis conflitos de interesses entre os entes consorciados. O estudo contribuiu ao avançar com relação à literatura existente e também com os gestores públicos, principalmente por apresentar a importância da atuação accountable no âmbito público, em especial no caso dos consórcios públicos.
Characterization of silicon oxynitride films deposited by a high-power impulse magnetron sputtering deposition technique
Authors: Liao Bo-Huei , Hsiao Chien-Nan , Shiao Ming-Hua , Chen Sheng-Hui
Published: January 2020

In this research, silicon oxynitride films were prepared by high-power impulse
magnetron sputtering with 45/955 pulse on/off time. The extinction
coefficient was smaller than

1

×

10

−
3

from 250 to 700 nm after introducing
2.2 sccm

O

2

gas at room temperature. A
three-layer of

A
l
F

3

/

S
i
O

x

N

y

AR coating was designed and
fabricated on double-sided quartz, and a high transmittance of 99.2%
was attained at 248 nm. The silicon oxynitride films deposited at
350°C had the better mechanical and optical properties in the visible
range. The hardness of all deposited films was greater than 19 GPa,
and the greatest hardness could reach to 29.8 GPa. A film structure of
six-layer transparent hard coating/glass/four-layer AR coating was
designed and deposited. Its average transmittance was 96.0% in the
visible range, while its hardness was 21 GPa and its surface roughness
was 0.23 nm.
Bringing an Historic Collection into the Modern Era: Curating the J. K. Underwood Seed Collection at the University of Tennessee Herbarium (TENN)
Authors: Miller Chelsea N. , Brabazon Holly , Ware Ian M. , Kingsley Nathaniel H. , Budke Jessica M.
Published: January 2020

The University of Tennessee Herbarium (TENN) presents a case study for modernizing an historic seed collection. TENN staff recently rediscovered the J. K. Underwood Seed Collection (ca. 1931–1964), containing over 700 unique specimens, hidden away in storage. We employed a series of curation actions to modernize the collection and render it useful to researchers. This included physically organizing and digitally indexing the collection, updating scientific names to current taxonomy, storing the specimens in modern archival-quality containers, housing the collection in environmentally-controlled conditions, and increasing accessibility of the collection by photographing specimens and integrating these images into our existing website (tenn.bio.utk.edu). Our efforts also included developing a protocol for adding new accessions to the collection and advertising the utility of the collection as a source of morphological data on seeds for identification, research, and teaching. We also review modern strategies for curating seed collections. Specifically, we emphasize the importance of increasing visibility of collections through visual, digital representations. This expands the utility of collections and fosters global information sharing across disciplines. We present our curation project as a case study that can serve as a model for curating historic seed collections.
Manajemen Kurikulum Pendidikan Agama Islam bagi Anak Berkebutuhan Khusus di SLB Al Azhar Bukittinggi
Authors: Wahyuni Sri Intan
Published: January 2020

The purpose of this research is to analyse the implementation of the curriculum management of Islamic education subject for students with special needs in SLB Al Azhar , Bukittinggi. This research used qualitative approach. The data was collected through observation and interview with Islamic education teachers, the curriculum vice principal for curriculum affairs  and the head master of the school. The result showed that  1) The curriculum is designed by the vice principal for curriculum affairs and the Islamic education teachers by providing syllabus and daily instructional plan appropriate for all types of disabilities in SLB Al Azhar Bukittinggi. 2) the curriculum is implemented by teacher in instructional process by adjusting the material with the lowest types of disabilities in the class, 3) the assessment is conducted through teaching-learning evaluation and assignment given to students with disabilities. However, some teachers still have difficulties in teaching due to the lack of educational background related to special education.
Makna Kata Anuq dalam Bahasa Sasak di SMP Negeri 2 Batukliang Utara
Authors: Andini Hollysa , Mahyuni Mahyuni , Nuriadi Nuriadi
Published: January 2020

This research is aimed at describing the meaning of the word “anuq” which is commonly spoken by Sasak people in SMP Negeri 2 Batukliang Utara using semantics theory. The source of data were the conversations among teachers and administrators of SMP Negeri 2 Batukliang Utara. The data were collected by applying listening, speaking, and introspection method. The result of the research showed that the word “anuq”has many meanings based on the context or topics of the communication. Sasak people in SMP Negeri 2 Batukliang Utara basically used “anuq” when the speaker forgot or lost the word to be spoken.
Analisis Tentang Hubungan Antara Cerpen Reaching For The Sky Karya Mitchell Waldman dengan Teori Strukturalisme Genetik
Authors: Nurmartanti Oryza
Published: January 2020

The journal entitled "Analysis of the Relationship between Reaching For The Sky Short Story and Genetic Structural Theory" aims to describe the genetic structuralistic relationship shown in the study of Reaching For The Sky short stories. This research uses descriptive analysis method by using literary sociology analysis techniques. Short Story Reaching For The Sky is an interesting to be chosen because it is thought to show the relationship between structuralism theory and social inequality.The results showed that the short story Reaching For The Sky by Mitchell Waldman is work that is full of criticism about social class inequality that occurs in Brooklyn, New York, USA. This short story besides carrying the theme of social class, can also be examined more deeply using the theory of Genetic Structuralism. This can be achieved because between the short story and the author, there is a very close relationship. Can be identified through the author's background and what is in the short story. Characters, settings, story lines, enough to represent the correlation of short stories, authors and theories that support the link between the short storyline and genetic structuralism. Among these are: facts of humanity, collective subjects, worldview, structuration and dialectics of understanding.
On performance stability in LSM-based storage systems
Authors: Luo Chen , Carey Michael J.
Published: January 2020

The Log-Structured Merge-Tree (LSM-tree) has been widely adopted for use in modern NoSQL systems for its superior write performance. Despite the popularity of LSM-trees, they have been criticized for suffering from write stalls and large performance variances due to the inherent mismatch between their fast in-memory writes and slow background I/O operations. In this paper, we use a simple yet effective two-phase experimental approach to evaluate write stalls for various LSM-tree designs. We further identify and explore the design choices of LSM merge schedulers to minimize write stalls given an I/O bandwidth budget. We have conducted extensive experiments in the context of the Apache AsterixDB system and we present the results here.
Panorama
Authors: Zhang Yuhao , Kumar Arun
Published: January 2020

Deep convolutional neural networks (CNNs) achieve state-of-the-art accuracy for many computer vision tasks. But using them for video monitoring applications incurs high computational cost and inference latency. Thus, recent works have studied how to improve system efficiency. But they largely focus on small "closed world" prediction vocabularies even though many applications in surveillance security, traffic analytics, etc. have an ever-growing set of target entities. We call this the "unbounded vocabulary" issue, and it is a key bottleneck for emerging video monitoring applications. We present the first data system for tacking this issue for video querying, Panorama. Our design philosophy is to build a unified and domain-agnostic system that lets application users generalize to unbounded vocabularies in an out-of-the-box manner without tedious manual re-training. To this end, we synthesize and innovate upon an array of techniques from the ML, vision, databases, and multimedia systems literature to devise a new system architecture. We also present techniques to ensure Panorama has high inference efficiency. Experiments with multiple real-world datasets show that Panorama can achieve between 2x to 20x higher efficiency than baseline approaches on in-vocabulary queries, while still yielding comparable accuracy and also generalizing well to unbounded vocabularies.