bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables 1 - 4 from The Dual Pathway Inhibitor Rigosertib Is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas
Authors: Anderson Ryan T. , Keysar Stephen B. , Bowles Daniel W. , Glogowska Magdalena J. , Astling David P. , Morton J. Jason , Le Phuong , Umpierrez Adrian , Eagles-Soukup Justin , Gan Gregory N. , Vogler Brian W. , Sehrt Daniel , Takimoto Sarah M. , Aisner Dara L. , Wilhelm Francois , Frederick Barbara A. , Varella-Garcia Marileila , Tan Aik-Choon , Jimeno Antonio
Published: April 2023

PDF file - 112K, Supplementary Table 1. Cell Line GSEA; Supplementary Table 2. Cell Line Mutation Status; Supplementary Table 3. PIK3CA Amplification in the Orthotopically Implanted Cell Lines; Supplementary 4 PIK3CA Amplification in the Direct Patient Xenograft Tumor Lines
Supplementary Figure Legend from The Dual Pathway Inhibitor Rigosertib Is Effective in Direct Patient Tumor Xenografts of Head and Neck Squamous Cell Carcinomas
Authors: Anderson Ryan T. , Keysar Stephen B. , Bowles Daniel W. , Glogowska Magdalena J. , Astling David P. , Morton J. Jason , Le Phuong , Umpierrez Adrian , Eagles-Soukup Justin , Gan Gregory N. , Vogler Brian W. , Sehrt Daniel , Takimoto Sarah M. , Aisner Dara L. , Wilhelm Francois , Frederick Barbara A. , Varella-Garcia Marileila , Tan Aik-Choon , Jimeno Antonio
Published: April 2023

PDF file - 64K
Supplementary Figure Legends 1-5 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 60K
Supplementary Figure 5 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 625K
Supplementary Figure 7 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 2791KB. A2058 (upper panels), MDA-MB231 (lower panels) and U87MG cells grown on coverslips were treated for 6 h, 6 h with a subsequent 18 h washout period or 24 h with either 5 μM BKM120 or 100 nM Nocodazole and the effects of compound treatment on microtubule dynamics and G2/M arrest was monitored by immuno-fluorescence staining of alpha-tubulin. Pictures were taken with a 40X objective.
Supplementary Figure 5 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 113KB, A. Effects of Paclitaxel and Nocodazole on Tubulin polymerization. Tubulin was mixed with either Paclitaxel (10 �M), Nocodazole (10 �M) or the DMSO control in the presence of GTP. The polymerization of monomeric tubulin into microtubule was started by transferring the reaction tubes from 4{degree sign}C to 37{degree sign}C, and monitored by the increase in absorbance (λ=340 nM) over a period of 60 min. B. Competition experiments of NVP-BKM120 with colchicine and podophyllotoxin by NMR spectroscopy. T1ρ relaxation of BKM120 in the presence of tubulin (50-fold excess of compound) remains unchanged after adding podophyllotoxin or colchicine, as emphasized by the drawn arrows. The spectra of the three compounds are shown in three colors at the bottom. C. Structures of GDC0941, BEZ235, Nocodazole and BKM120.
Supplementary Figure 2 from Gene Expression Profile in Response to Doxorubicin–Rapamycin Combined Treatment of HER-2–Overexpressing Human Mammary Epithelial Cell Lines
Authors: Trapé Adriana Priscila , Katayama Maria Lucia Hirata , Roela Rosimeire Aparecida , Brentani Helena , Ravacci Graziela Rosa , de Araujo Lima Leandro , Brentani Maria Mitzi
Published: April 2023

PDF file - 409K
Supplementary Figure 3 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 53KB, A and B. 5x105 A2058 cells were seeded in 10 cm dishes and incubated for 24 h either with increasing amounts of BKM120 (A) or with 5 �M of either GDC-0941 (B, top panel) or BEZ235 (B, bottom panel). Cells were then fixed, prepared as described for quantification of the population in the different phases of the cell cycle by fluorescence-activated cell sorting. G1, S and G2/M distribution for control untreated cells are described in the mean text and in Figure 4A. The activities of BKM120 on the cell cycle were plotted along to the inhibitory effects on pAkt levels (A).
Supplementary Figures 1 - 4 from BRAF V600E Is a Determinant of Sensitivity to Proteasome Inhibitors
Authors: Zecchin Davide , Boscaro Valentina , Medico Enzo , Barault Ludovic , Martini Miriam , Arena Sabrina , Cancelliere Carlotta , Bartolini Alice , Crowley Emily H. , Bardelli Alberto , Gallicchio Margherita , Di Nicolantonio Federica
Published: April 2023

PDF file - 635K, Supplementary Figure S1. Genotypes included in the combinatorial genetic matrix. PTEN or RB1 were silenced by shRNA in isogenic KI cells.
Supplementary Figure 1 from Characterization of the Mechanism of Action of the Pan Class I PI3K Inhibitor NVP-BKM120 across a Broad Range of Concentrations
Authors: Brachmann Saskia M. , Kleylein-Sohn Julia , Gaulis Swann , Kauffmann Audrey , Blommers Marcel J.J. , Kazic-Legueux Malika , Laborde Laurent , Hattenberger Marc , Stauffer Fabian , Vaxelaire Juliane , Romanet Vincent , Henry Chrystèle , Murakami Masato , Guthy Daniel Alexander , Sterker Dario , Bergling Sebastian , Wilson Christopher , Brümmendorf Thomas , Fritsch Christine , Garcia-Echeverria Carlos , Sellers William R. , Hofmann Francesco , Maira Sauveur-Michel
Published: April 2023

PDF file, 71KB, The data are scaled by the positive control (1�M MG132) and the negative control (DMSO). The percentage of maximum activity (Amax) is represented in function of the crossing point (concentration in �M at 50% of MG132 activity). Each data point represents a cell line; the vertical and horizontal lines represent, respectively, the median of the crossing point values (1.33�M) and the median of the Amax values (-90.06%), of BKM120 across all cell lines. The populations of cell lines least responding to GDC-0941, among which some are sensitive to BKM120, are highlighted in green.
Supplementary Methods, Figure Legend, Table 1 from Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo
Authors: Janzen Deanna M. , Paik Daniel Y. , Rosales Miguel A. , Yep Brian , Cheng Donghui , Witte Owen N. , Kayadibi Huseyin , Ryan Christopher M. , Jung Michael E. , Faull Kym , Memarzadeh Sanaz
Published: April 2023

PDF file - 84K, Supplementary Table S1. Antibodies used for immunostaining.
Supplementary Figure 3 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 139K, Expression of endogenous p53 protein in SaOS-2 and MNNG/HOS cells
Supplementary Figure 3 from Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo
Authors: Janzen Deanna M. , Paik Daniel Y. , Rosales Miguel A. , Yep Brian , Cheng Donghui , Witte Owen N. , Kayadibi Huseyin , Ryan Christopher M. , Jung Michael E. , Faull Kym , Memarzadeh Sanaz
Published: April 2023

PDF file - 80K, Figure S3. Decreased levels of Cyp3A4 were detected in estrogen depleted mice.
Supplementary Figure 1 from Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
Authors: Hasei Joe , Sasaki Tsuyoshi , Tazawa Hiroshi , Osaki Shuhei , Yamakawa Yasuaki , Kunisada Toshiyuki , Yoshida Aki , Hashimoto Yuuri , Onishi Teppei , Uno Futoshi , Kagawa Shunsuke , Urata Yasuo , Ozaki Toshifumi , Fujiwara Toshiyoshi
Published: April 2023

PDF file - 250K, The structures of OBP-301 and OBP-702
Supplementary Figure 1 from Low Levels of Circulating Estrogen Sensitize PTEN-Null Endometrial Tumors to PARP Inhibition In Vivo
Authors: Janzen Deanna M. , Paik Daniel Y. , Rosales Miguel A. , Yep Brian , Cheng Donghui , Witte Owen N. , Kayadibi Huseyin , Ryan Christopher M. , Jung Michael E. , Faull Kym , Memarzadeh Sanaz
Published: April 2023

PDF file - 422K, Figure S1. Despite Olaparib therapy, PTEN-null endometrial tumors persisted and resembled human endometrial endometrioid cancers.
Supplementary Methods and Figure Legend from Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
Authors: Portmann Simone , Fahrner René , Lechleiter Antje , Keogh Adrian , Overney Sarah , Laemmle Alexander , Mikami Kei , Montani Matteo , Tschan Mario P. , Candinas Daniel , Stroka Deborah
Published: April 2023

PDF file - 111K
Supplementary Figure 3 from Antitumor Effect of SIRT1 Inhibition in Human HCC Tumor Models In Vitro and In Vivo
Authors: Portmann Simone , Fahrner René , Lechleiter Antje , Keogh Adrian , Overney Sarah , Laemmle Alexander , Mikami Kei , Montani Matteo , Tschan Mario P. , Candinas Daniel , Stroka Deborah
Published: April 2023

PDF file - 233K, Inhibition of SIRT1 with cambinol in Hep3B cells
Supplementary Figures 1 - 3, Table 1 from Targeting the Insulin Growth Factor and the Vascular Endothelial Growth Factor Pathways in Ovarian Cancer
Authors: Shao Minghai , Hollar Stacy , Chambliss Daphne , Schmitt Jordan , Emerson Robert , Chelladurai Bhadrani , Perkins Susan , Ivan Mircea , Matei Daniela
Published: April 2023

PDF file, 152KB.
Supplementary Figures 1 - 4 from Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K
Authors: Munck Joanne M. , Batey Michael A. , Zhao Yan , Jenkins Helen , Richardson Caroline J. , Cano Celine , Tavecchio Michele , Barbeau Jody , Bardos Julia , Cornell Liam , Griffin Roger J. , Menear Keith , Slade Andrew , Thommes Pia , Martin Niall M.B. , Newell David R. , Smith Graeme C.M. , Curtin Nicola J.
Published: April 2023

PDF file, 316KB.
Supplementary Figure 6 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 2958K, Figure S6. Overexpression of AMPKα1 rescues miR-148b-induced apoptosis and cell cycle arrest and invasion inhibition of pancreatic cancer cells.
Supplementary Figure 4 from Spongian Diterpenoids Inhibit Androgen Receptor Activity
Authors: Yang Yu Chi , Meimetis Labros G. , Tien Amy H. , Mawji Nasrin R. , Carr Gavin , Wang Jun , Andersen Raymond J. , Sadar Marianne D.
Published: April 2023

PDF File - 72K, Levels of AR protein in cell lines.
Supplementary Figure 3 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 3185K, Figure S3. Overexpression of AMPKα1 in pancreatic cancer tissues and cell lines and inversely correlate with miR-148b levels.
Supplementary Figure 2 from Spongian Diterpenoids Inhibit Androgen Receptor Activity
Authors: Yang Yu Chi , Meimetis Labros G. , Tien Amy H. , Mawji Nasrin R. , Carr Gavin , Wang Jun , Andersen Raymond J. , Sadar Marianne D.
Published: April 2023

PDF File - 81K, Growth assay for LNCaP, VCaP, and PC3 cells.
Supplementary Figure 1 from miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKα1
Authors: Zhao Gang , Zhang Jun-Gang , Liu Yang , Qin Qi , Wang Bo , Tian Kui , Liu Lin , Li Xiang , Niu Yi , Deng Shi-Chang , Wang Chun-You
Published: April 2023

PDF file - 2016K, Figure S1. MiR-148b enhances chemosensitivity of pancreatic cancer cells.
Supplementary Table 1 from Antitumor Activity of Src Inhibitor Saracatinib (AZD-0530) in Preclinical Models of Biliary Tract Carcinomas
Authors: Cavalloni Giuliana , Peraldo-Neia Caterina , Sarotto Ivana , Gammaitoni Loretta , Migliardi Giorgia , Soster Marco , Marchiò Serena , Aglietta Massimo , Leone Francesco
Published: April 2023

PDF file, 61KB, Clinical pathological characteristics of BTC patients.
Supplementary Table 1 from A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity
Authors: Olwill Shane A. , Joffroy Christian , Gille Hendrik , Vigna Elisa , Matschiner Gabriele , Allersdorfer Andrea , Lunde Bradley M. , Jaworski Jakub , Burrows James F. , Chiriaco Cristina , Christian Hans Jürgen , Hülsmeyer Martin , Trentmann Stefan , Jensen Kristian , Hohlbaum Andreas M. , Audoly Laurent
Published: April 2023

PDF - 53KB, Demonstration of benign immunogenicity profile of PRS-110 in ex vivo PBMC model
Supplementary Figure 2 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer
Authors: Williams Terence M. , Flecha Athena R. , Keller Paul , Ram Ashwin , Karnak David , Galbán Stefanie , Galbán Craig J. , Ross Brian D. , Lawrence Theodore S. , Rehemtulla Alnawaz , Sebolt-Leopold Judith
Published: April 2023

PDF file, 41KB, Changes in weight during the study period for the mice randomized to the eight treatment groups described.
Supplementary Figure Legend from A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity
Authors: Olwill Shane A. , Joffroy Christian , Gille Hendrik , Vigna Elisa , Matschiner Gabriele , Allersdorfer Andrea , Lunde Bradley M. , Jaworski Jakub , Burrows James F. , Chiriaco Cristina , Christian Hans Jürgen , Hülsmeyer Martin , Trentmann Stefan , Jensen Kristian , Hohlbaum Andreas M. , Audoly Laurent
Published: April 2023

Text legends for each supplementary figure
Supplementary Figure 1 from Cotargeting MAPK and PI3K Signaling with Concurrent Radiotherapy as a Strategy for the Treatment of Pancreatic Cancer
Authors: Williams Terence M. , Flecha Athena R. , Keller Paul , Ram Ashwin , Karnak David , Galbán Stefanie , Galbán Craig J. , Ross Brian D. , Lawrence Theodore S. , Rehemtulla Alnawaz , Sebolt-Leopold Judith
Published: April 2023

PDF file, 318KB, Dose dependency of PD0325901 in multiple cell lines. Treatment with PD0325901 induces potent inhibition of pERK-1/2 levels at one and three hours.
Supplementary Figure 2 from A Highly Potent and Specific MET Therapeutic Protein Antagonist with Both Ligand-Dependent and Ligand-Independent Activity
Authors: Olwill Shane A. , Joffroy Christian , Gille Hendrik , Vigna Elisa , Matschiner Gabriele , Allersdorfer Andrea , Lunde Bradley M. , Jaworski Jakub , Burrows James F. , Chiriaco Cristina , Christian Hans Jürgen , Hülsmeyer Martin , Trentmann Stefan , Jensen Kristian , Hohlbaum Andreas M. , Audoly Laurent
Published: April 2023

PDF - 136KB, Demonstration of PRS-110 dependent MET trafficking in HT29 cells
Supplementary Figure 1 from Quantitative Chemical Proteomics Profiling Differentiates Erlotinib from Gefitinib in EGFR Wild-Type Non–Small Cell Lung Carcinoma Cell Lines
Authors: Augustin Angélique , Lamerz Jens , Meistermann Hélène , Golling Sabrina , Scheiblich Stefan , Hermann Johannes C. , Duchateau-Nguyen Guillemette , Tzouros Manuel , Avila David W. , Langen Hanno , Essioux Laurent , Klughammer Barbara
Published: April 2023

PDF file - 60K, Schematic diagram of the experimental framework applied to perform label-free, quantitative chemical proteomics on erlotinib and gefitinib
Supplementary Figure Legends from Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein–Barr Virus
Authors: Hui Kwai Fung , Lam Benjamin H.W. , Ho Dona N. , Tsao Sai Wah , Chiang Alan K.S.
Published: April 2023

PDF File - 24K, Legends for Supplementary Figures 1-4.
Supplementary Figures 1 - 6 from In Silico Screening Reveals Structurally Diverse, Nanomolar Inhibitors of NQO2 That Are Functionally Active in Cells and Can Modulate NF-κB Signaling
Authors: Nolan Karen A. , Dunstan Mark S. , Caraher Mary C. , Scott Katherine A. , Leys David , Stratford Ian J.
Published: April 2023

PDF file - 626KB
Supplementary Figure 4 from Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein–Barr Virus
Authors: Hui Kwai Fung , Lam Benjamin H.W. , Ho Dona N. , Tsao Sai Wah , Chiang Alan K.S.
Published: April 2023

PDF File - 5453K, Effects of bortezomib/SAHA on tumor growth suppression of HONE1 and HA NPC xenografts in nude mice.
Supplementary Figure 1 from Bortezomib and SAHA Synergistically Induce ROS-Driven Caspase-Dependent Apoptosis of Nasopharyngeal Carcinoma and Block Replication of Epstein–Barr Virus
Authors: Hui Kwai Fung , Lam Benjamin H.W. , Ho Dona N. , Tsao Sai Wah , Chiang Alan K.S.
Published: April 2023

PDF File - 1787K, Cytotoxicity of bortezomib/SAHA on normal nasopharyngeal and kidney cells.
Supplementary Figure Legend from Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models
Authors: Herter Sylvia , Herting Frank , Mundigl Olaf , Waldhauer Inja , Weinzierl Tina , Fauti Tanja , Muth Gunter , Ziegler-Landesberger Doris , Van Puijenbroek Erwin , Lang Sabine , Duong Minh Ngoc , Reslan Lina , Gerdes Christian A. , Friess Thomas , Baer Ute , Burtscher Helmut , Weidner Michael , Dumontet Charles , Umana Pablo , Niederfellner Gerhard , Bacac Marina , Klein Christian
Published: April 2023

PDF file - 43K
Supplementary Figure 2 from Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models
Authors: Herter Sylvia , Herting Frank , Mundigl Olaf , Waldhauer Inja , Weinzierl Tina , Fauti Tanja , Muth Gunter , Ziegler-Landesberger Doris , Van Puijenbroek Erwin , Lang Sabine , Duong Minh Ngoc , Reslan Lina , Gerdes Christian A. , Friess Thomas , Baer Ute , Burtscher Helmut , Weidner Michael , Dumontet Charles , Umana Pablo , Niederfellner Gerhard , Bacac Marina , Klein Christian
Published: April 2023

PDF file - 307K, Whole-blood B-cell depletion mediated by GA101 (black squares), rituximab (open diamonds), and ofatumumab (open triangles) in lepirudin-treated (A, B) and heat-inactivated (HI) (C) whole-blood samples. GA101 mediated superior B-cell depletion in human whole-blood samples in all experimental conditions (A-C). Heat inactivation of human serum revealed that, in contrast to GA101, ofatumumab and rituximab rely more strongly on complement for efficient B-cell depletion (C). The average B-cell depletion and standard deviations were calculated from the triplicates of each experiment.
Supplementary Figure 1 from Antitumor Action of the MET Tyrosine Kinase Inhibitor Crizotinib (PF-02341066) in Gastric Cancer Positive for MET Amplification
Authors: Okamoto Wataru , Okamoto Isamu , Arao Tokuzo , Kuwata Kiyoko , Hatashita Erina , Yamaguchi Haruka , Sakai Kazuko , Yanagihara Kazuyoshi , Nishio Kazuto , Nakagawa Kazuhiko
Published: April 2023

PDF file, 123KB, Effects of crizotinib (50 nM) on MET, AKT, ERK and STAT3 phosphorylation in gastric cancer cells with MET amplification.
Supplementary Methods from Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2
Authors: van Leeuwen Ingeborg M.M. , Higgins Maureen , Campbell Johanna , McCarthy Anna R. , Sachweh Marijke C.C. , Navarro Ana Marín , Laín Sonia
Published: April 2023

PDF file - 91K
Supplementary Figures 1 - 7 from MTI-101 (Cyclized HYD1) Binds a CD44 Containing Complex and Induces Necrotic Cell Death in Multiple Myeloma
Authors: Gebhard Anthony W. , Jain Priyesh , Nair Rajesh R. , Emmons Michael F. , Argilagos Raul F. , Koomen John M. , McLaughlin Mark L. , Hazlehurst Lori A.
Published: April 2023

PDF file - 903K, Supplementary Figure S1: MTI-101 is more potent in U266 cell line than linear parent peptide and biotinylated peptides still retain bioactivity; Supplementary Figure S2: Biotin-HYD1 binding complex in NCI-H929 and U266 MM cell lines; Supplementary Figure S3: Overexpression of CD44s in 8226 via retroviral infection results in functional CD44; Supplementary Figure S4: Reduction in syndecan-1 expression failed to confer resistance to MTI-101 induced cell death; Supplementary Figure S5: Reduction in basigin expression failed to confer resistance to MTI-101 induced cell death; Supplementary Figure S6: MTI-101 necrotic cell death in Rip1/Rip3 and Drp1 independent in NCI-H929 cell line, but partially involved in U266; Supplementary S7: MTI-101 has activity as a single agent in 5TGM1 in vivo mouse model.
Supplementary Figure Legend from MTI-101 (Cyclized HYD1) Binds a CD44 Containing Complex and Induces Necrotic Cell Death in Multiple Myeloma
Authors: Gebhard Anthony W. , Jain Priyesh , Nair Rajesh R. , Emmons Michael F. , Argilagos Raul F. , Koomen John M. , McLaughlin Mark L. , Hazlehurst Lori A.
Published: April 2023

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Supplementary Figure 3 from Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2
Authors: van Leeuwen Ingeborg M.M. , Higgins Maureen , Campbell Johanna , McCarthy Anna R. , Sachweh Marijke C.C. , Navarro Ana Marín , Laín Sonia
Published: April 2023

PDF file - 129K, Co-expression mdm2 and p14ARF increases acetylated p53 in the nuclear fraction without affecting the level of SirT1 protein
Supplementary Table 2 from HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo
Authors: Kawamoto Megumi , Horibe Tomohisa , Kohno Masayuki , Kawakami Koji
Published: April 2023

PDF file - 61 KB, Single-dose toxicity study of HER2-lytic in mice. BALB/c mice were received HER2-lytic peptide as intravenous injections (50 ��l/injection).
Supplementary Table 1 from HER2-Targeted Hybrid Peptide That Blocks HER2 Tyrosine Kinase Disintegrates Cancer Cell Membrane and Inhibits Tumor Growth In Vivo
Authors: Kawamoto Megumi , Horibe Tomohisa , Kohno Masayuki , Kawakami Koji
Published: April 2023

PDF file - 123 KB, Hematology and serum metabolic panel. Mean�}SD (n=3 mice/group�j. Statistical values are between the 2 groups. AST; aspartate aminotransferase, ALT; alanine aminotransferase, ALP alkaline phosphatase, LDH; lactate dehydrogenase, CPK; creatine phosphokinase
Supplementary Methods from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 55K
Supplementary Table 1 from MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1
Authors: Sun Ming , Liu Xiang-hua , Li Jin-hai , Yang Jin-song , Zhang Er-bao , Yin Dan-dan , Liu Zhi-li , Zhou Jing , Ding Ying , Li Su-qin , Wang Zhao-xia , Cao Xiu-feng , De Wei
Published: April 2023

PDF file - 49K, Correlation of the expression of miR-196a with clinicopathologic features.
Supplementary Figure 3 from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 151K, Assessment of phospho-AKT and total AKT in VCaP xenografts treated with combined androgen-deprivation therapy (castration) and ganitumab
Supplementary Figure 1 from Targeting IGF-IR with Ganitumab Inhibits Tumorigenesis and Increases Durability of Response to Androgen-Deprivation Therapy in VCaP Prostate Cancer Xenografts
Authors: Fahrenholtz Cale D. , Beltran Pedro J. , Burnstein Kerry L.
Published: April 2023

PDF file - 65K, Schematic of IGF-1R Signaling Pathways
Supplementary Figure 7 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Authors: Zaidi Nousheen , Royaux Ines , Swinnen Johannes V. , Smans Karine
Published: April 2023

PDF file, 80KB, Growth curves for PC3M cells with/without soraphen and/or cholesterol supplementation.
Supplementary Table 1 from Cooperation between c-Met and Focal Adhesion Kinase Family Members in Medulloblastoma and Implications for Therapy
Authors: Guessous Fadila , Yang Yanzhi , Johnson Elizabeth , Marcinkiewicz Lukasz , Smith Matthew , Zhang Ying , Kofman Alexander , Schiff David , Christensen James , Abounader Roger
Published: April 2023

PDF file - 39K
Supplementary Figure 1 from YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context
Authors: Jane Esther P. , Premkumar Daniel R. , DiDomenico Joseph D. , Hu Bo , Cheng Shi-Yuan , Pollack Ian F.
Published: April 2023

PDF file - 69K, Effect of YM-155 and ABT-737 on human astrocytes
Supplementary Figure 1 from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms
Authors: Zaidi Nousheen , Royaux Ines , Swinnen Johannes V. , Smans Karine
Published: April 2023

PDF file, 27KB, Reduction in mRNA expression of ACLY by IPTG-inducible shRNA targeting ACLY in HOP62 and HepG2 cells.
Supplementary Table 3 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
Authors: Meng Zhipeng , Li Tao , Ma Xiaoxiao , Wang Xiaoqiong , Van Ness Carl , Gan Yichao , Zhou Hong , Tang Jinfen , Lou Guiyu , Wang Yafan , Wu Jun , Yen Yun , Xu Rongzhen , Huang Wendong
Published: April 2023

XLSX file, 12K, Phosphorylation of CAMKII in liver cancer patients.
Supplementary Methods, Figure Legend from MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo
Authors: Jenkins David W. , Ross Sarah , Veldman-Jones Margaret , Foltz Ian N. , Clavette Brandon C. , Manchulenko Kathy , Eberlein Cath , Kendrew Jane , Petteruti Philip , Cho Song , Damschroder Melissa , Peng Li , Baker Dawn , Smith Neil R. , Weir Hazel M. , Blakey David C. , Bedian Vahe , Barry Simon T.
Published: April 2023

PDF file - 98K
Supplementary Table 1 from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
Authors: Meng Zhipeng , Li Tao , Ma Xiaoxiao , Wang Xiaoqiong , Van Ness Carl , Gan Yichao , Zhou Hong , Tang Jinfen , Lou Guiyu , Wang Yafan , Wu Jun , Yen Yun , Xu Rongzhen , Huang Wendong
Published: April 2023

XLSX file, 9K, IC50s of berbamine on liver cancer cells.
Supplementary Figures from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
Authors: Meng Zhipeng , Li Tao , Ma Xiaoxiao , Wang Xiaoqiong , Van Ness Carl , Gan Yichao , Zhou Hong , Tang Jinfen , Lou Guiyu , Wang Yafan , Wu Jun , Yen Yun , Xu Rongzhen , Huang Wendong
Published: April 2023

PDF file, 1752K, Figure S1. (Related to Figure 2) BBM suppresses the xenograft growth of Huh7 and SK-Hep-1 cells; Figure S2. (Related to Figure 3) BBM is localized in cytoplasm and affects cell survival; Figure S3. (Related to Figure 4) BBM suppressed the CD133+ population in Huh7 cells; Figure S4. (Related to Figure 5B). The chemical inhibitor of CAMKII, KN93, suppresses CD133+ population in Huh7 cells; Figure S6. (Related to Figure 6C). The knockdown of CAMKIIgamma suppresses liver cancer growth.
Supplementary Figure Legends from Berbamine Inhibits the Growth of Liver Cancer Cells and Cancer-Initiating Cells by Targeting Ca2+/Calmodulin-Dependent Protein Kinase II
Authors: Meng Zhipeng , Li Tao , Ma Xiaoxiao , Wang Xiaoqiong , Van Ness Carl , Gan Yichao , Zhou Hong , Tang Jinfen , Lou Guiyu , Wang Yafan , Wu Jun , Yen Yun , Xu Rongzhen , Huang Wendong
Published: April 2023

PDF file, 51K.
Supplementary Figure Legend 1 from MK-2206, a Novel Allosteric Inhibitor of Akt, Synergizes with Gefitinib against Malignant Glioma via Modulating Both Autophagy and Apoptosis
Authors: Cheng Yan , Zhang Yi , Zhang Li , Ren Xingcong , Huber-Keener Kathryn J. , Liu Xiaoyuan , Zhou Lei , Liao Jason , Keihack Heike , Yan Li , Rubin Eric , Yang Jin-Ming
Published: April 2023

PDF file - 72K
Supplementary Table 1 from SAR131675, a Potent and Selective VEGFR-3–TK Inhibitor with Antilymphangiogenic, Antitumoral, and Antimetastatic Activities
Authors: Alam Antoine , Blanc Isabelle , Gueguen-Dorbes Geneviève , Duclos Olivier , Bonnin Jacques , Barron Pauline , Laplace Marie-Claude , Morin Gaelle , Gaujarengues Florence , Dol Frédérique , Hérault Jean-Pascal , Schaeffer Paul , Savi Pierre , Bono Françoise
Published: April 2023

PDF file - 76K, This file shows the effect of SAR131675 on a number of recombinant kinases
Supplementary Figure 4 from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 5124KB, YM155 and cisplatin combination treatment significantly inhibits tumor cell motility. Tumor cell motility was examined by scratch assay.
Supplementary Figure 1 from YM155 Reverses Cisplatin Resistance in Head and Neck Cancer by Decreasing Cytoplasmic Survivin Levels
Authors: Kumar Bhavna , Yadav Arti , Lang James C. , Cipolla Michael J. , Schmitt Alessandra C. , Arradaza Nicole , Teknos Theodoros N. , Kumar Pawan
Published: April 2023

PDF file, 995KB, YM155 inhibits tumor cell proliferation in a dose-dependent manner. Cell proliferation in tumor cells (UM-SCC-74A or CAL27-CisR) or human oral keratinocytes (HOK) was assessed by MTT assay after 72 hrs.
Supplementary Figure Legend from Synthetic Lethal Screening with Small-Molecule Inhibitors Provides a Pathway to Rational Combination Therapies for Melanoma
Authors: Roller Devin G. , Axelrod Mark , Capaldo Brian J. , Jensen Karin , Mackey Aaron , Weber Michael J. , Gioeli Daniel
Published: April 2023

PDF file, 72K.
Supplementary Figure Legends 1-4 from Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Authors: Previdi Sara , Abbadessa Giovanni , Dalò Francesca , France Dennis S. , Broggini Massimo
Published: April 2023

PDf file - 59K
Supplementary Figure 2 from Sensitization of TRAIL-Induced Cell Death by 20(S)-Ginsenoside Rg3 via CHOP-Mediated DR5 Upregulation in Human Hepatocellular Carcinoma Cells
Authors: Lee Ju-Yeon , Jung Kyung Hee , Morgan Michael J. , Kang Yi-Rae , Lee Hee-Seung , Koo Gi-Bang , Hong Soon-Sun , Kwon Sung Won , Kim You-Sun
Published: April 2023

PDF file - 765K, Sensitization of Rg3 in TRAIL- induced cell death is dose dependent in HepG2 cells
Supplementary Figure 1 from Breast Cancer–Derived Bone Metastasis Can Be Effectively Reduced through Specific c-MET Inhibitor Tivantinib (ARQ 197) and shRNA c-MET Knockdown
Authors: Previdi Sara , Abbadessa Giovanni , Dalò Francesca , France Dennis S. , Broggini Massimo
Published: April 2023

PDF file - 150K
Supplementary Table 1 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 18K, Retention time of tenovin-D3 = 0.61 minutes.
Supplementary Figure Legend from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 27K
Supplementary Figure 7 from Tenovin-D3, a Novel Small-Molecule Inhibitor of Sirtuin SirT2, Increases p21 (CDKN1A) Expression in a p53-Independent Manner
Authors: McCarthy Anna R. , Sachweh Marijke C.C. , Higgins Maureen , Campbell Johanna , Drummond Catherine J. , van Leeuwen Ingeborg M.M. , Pirrie Lisa , Ladds Marcus J.G.W. , Westwood Nicholas J. , Laín Sonia
Published: April 2023

PDF file - 42K, MDAMB468 cells were treated with the indicated amounts of TSA for 6 hours.
Supplementary Table 3 from A Systems Biology Approach Identifies SART1 as a Novel Determinant of Both 5-Fluorouracil and SN38 Drug Resistance in Colorectal Cancer
Authors: Allen Wendy L. , Stevenson Leanne , Coyle Vicky M. , Jithesh Puthen V. , Proutski Irina , Carson Gail , Gordon Michael A. , Lenz Heinz-Josef D. , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 61K, unsupervised top 10 positive and negative correlated genes - 5-FU basal.
Supplementary Figure 1 from Targeting the Glyoxalase Pathway Enhances TRAIL Efficacy in Cancer Cells by Downregulating the Expression of Antiapoptotic Molecules
Authors: Taniguchi Hiroya , Horinaka Mano , Yoshida Tatsushi , Yano Kimihiro , Goda Ahmed E. , Yasuda Shusuke , Wakada Miki , Sakai Toshiyuki
Published: April 2023

PDF file, 171K, Expression of TRAIL receptors when treated with methylglyoxal.
Supplementary Figure 3 from Humanization of an Anti-CCR4 Antibody That Kills Cutaneous T-Cell Lymphoma Cells and Abrogates Suppression by T-Regulatory Cells
Authors: Chang De-Kuan , Sui Jianhua , Geng Shusheng , Muvaffak Asli , Bai Mei , Fuhlbrigge Robert C. , Lo Agnes , Yammanuru Anuradha , Hubbard Luke , Sheehan Jared , Campbell James J. , Zhu Quan , Kupper Thomas S. , Marasco Wayne A.
Published: April 2023

PDF file, 51K, Human mAb1567 variants mediated ADCC activity against Cf2-CCR4 cells via human NK cells.
Supplementary Figures 1-5 from Dual PI3K/AKT/mTOR Inhibitor BEZ235 Synergistically Enhances the Activity of JAK2 Inhibitor against Cultured and Primary Human Myeloproliferative Neoplasm Cells
Authors: Fiskus Warren , Verstovsek Srdan , Manshouri Taghi , Smith Jacqueline E. , Peth Karissa , Abhyankar Sunil , McGuirk Joseph , Bhalla Kapil N.
Published: April 2023

PDF File - 310K, Treatment with BEZ235 dose dependently inhibits PI3K/AKT and mTOR signaling in MPN cells.
Supplementary Methods from Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
Authors: Wan Shunzhou , Wright David W. , Coveney Peter V.
Published: April 2023

PDF file - 130K, More details of the simulation and analysis methods
Supplementary Figure Legends 1-3 from Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
Authors: Wan Shunzhou , Wright David W. , Coveney Peter V.
Published: April 2023

PDF file - 85K
Supplementary Figure 2 from Mechanism of Drug Efficacy Within the EGF Receptor Revealed by Microsecond Molecular Dynamics Simulation
Authors: Wan Shunzhou , Wright David W. , Coveney Peter V.
Published: April 2023

PDF file - 98K, The binding positions of gefitinib and ATP in the binding site of EGFR
Supplementary Figure Legend from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-κB Pathways
Authors: Wu Xinqi , Li Jingjing , Zhu Meijun , Fletcher Jonathan A. , Hodi F. Stephen
Published: April 2023

PDF file, 48KB.
Supplementary Figure 3 from Protein Kinase C Inhibitor AEB071 Targets Ocular Melanoma Harboring GNAQ Mutations via Effects on the PKC/Erk1/2 and PKC/NF-κB Pathways
Authors: Wu Xinqi , Li Jingjing , Zhu Meijun , Fletcher Jonathan A. , Hodi F. Stephen
Published: April 2023

PDF file, 61KB, Inhibition of NF-κB by IKK inhibitor vii resulted in reduced viability in both GNAQ wild type and mutated UM cells.
Supplementary Figure 2 from Niclosamide Overcomes Acquired Resistance to Erlotinib through Suppression of STAT3 in Non–Small Cell Lung Cancer
Authors: Li Rui , Hu Zhongliang , Sun Shi-Yong , Chen Zhuo G. , Owonikoko Taofeek K. , Sica Gabriel L. , Ramalingam Suresh S. , Curran Walter J. , Khuri Fadlo R. , Deng Xingming
Published: April 2023

PDF file, 46K, Structures of erlotinib and niclosamide.
Supplementary Figure 1 from Trans,trans,trans-[PtIV(N3)2(OH)2(py)(NH3)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
Authors: Westendorf Aron F. , Woods Julie A. , Korpis Katharina , Farrer Nicola J. , Salassa Luca , Robinson Kim , Appleyard Virginia , Murray Karen , Grünert Renate , Thompson Alastair M. , Sadler Peter J. , Bednarski Patrick J.
Published: April 2023

PDF file, 138KB, Representative Annexin-V flow cytometry results.
Supplementary Figure Legends from Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC
Authors: Dinnen Richard D. , Mao Yuehua , Qiu Wanglong , Cassai Nicholas , Slavkovich Vesna N. , Nichols Gwen , Su Gloria H. , Brandt-Rauf Paul , Fine Robert L.
Published: April 2023

PDF - 74KB, Legends to Supplementary Figures S1-S6.
Supplementary Figure Legend from BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application
Authors: Siemeister Gerhard , Lücking Ulrich , Wengner Antje M. , Lienau Philip , Steinke Wolfram , Schatz Christoph , Mumberg Dominik , Ziegelbauer Karl
Published: April 2023

PDF file, 80K.
Supplementary Figure 3 from BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application
Authors: Siemeister Gerhard , Lücking Ulrich , Wengner Antje M. , Lienau Philip , Steinke Wolfram , Schatz Christoph , Mumberg Dominik , Ziegelbauer Karl
Published: April 2023

PDF file, 137K, Cellular mode of action investigations.
Supplementary Figure 2 from BAY 1000394, a Novel Cyclin-Dependent Kinase Inhibitor, with Potent Antitumor Activity in Mono- and in Combination Treatment upon Oral Application
Authors: Siemeister Gerhard , Lücking Ulrich , Wengner Antje M. , Lienau Philip , Steinke Wolfram , Schatz Christoph , Mumberg Dominik , Ziegelbauer Karl
Published: April 2023

PDF file, 54K, Cell line panel, cell viability results upon BAY 1000394 treatment.
Supplementary Table 4 from Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed
Authors: Weeks Lachelle D. , Fu Pingfu , Gerson Stanton L.
Published: April 2023

PDF file - 42K, Cross-sensitivity of H1975 cells to other DNA damaging agents.
Supplementary Figure Legends 1-3 from HER2 As Therapeutic Target for Overcoming ATP-Binding Cassette Transporter–Mediated Chemoresistance in Small Cell Lung Cancer
Authors: Minami Toshiyuki , Kijima Takashi , Otani Yasushi , Kohmo Satoshi , Takahashi Ryo , Nagatomo Izumi , Hirata Haruhiko , Suzuki Mayumi , Inoue Koji , Takeda Yoshito , Kida Hiroshi , Tachibana Isao , Kumanogoh Atsushi
Published: April 2023

PDF file - 54K
Supplementary Table 1 from Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed
Authors: Weeks Lachelle D. , Fu Pingfu , Gerson Stanton L.
Published: April 2023

PDF file - 65K, Description of cell lines used in this study.
Supplementary Figure 2 from Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed
Authors: Weeks Lachelle D. , Fu Pingfu , Gerson Stanton L.
Published: April 2023

PDF file - 575K, Cross resistance of pemetrexed resistant subline to other DNA damaging agents.
Supplementary Figure 1 from Uracil–DNA Glycosylase Expression Determines Human Lung Cancer Cell Sensitivity to Pemetrexed
Authors: Weeks Lachelle D. , Fu Pingfu , Gerson Stanton L.
Published: April 2023

PDF file - 997K, AP site detection in H1975 and H1975shUNG (66) cells.
Supplementary Materials and Methods from The Novel ATP-Competitive Inhibitor of the MET Hepatocyte Growth Factor Receptor EMD1214063 Displays Inhibitory Activity against Selected MET-Mutated Variants
Authors: Medová Michaela , Pochon Benoît , Streit Bruno , Blank-Liss Wieslawa , Francica Paola , Stroka Deborah , Keogh Adrian , Aebersold Daniel M. , Blaukat Andree , Bladt Friedhelm , Zimmer Yitzhak
Published: April 2023

PDF - 38KB, Supplementary Materials and Methods
Supplementary Materials and Methods from Characterization of a New Class of Androgen Receptor Antagonists with Potential Therapeutic Application in Advanced Prostate Cancer
Authors: Li Huifang , Hassona Mohamed D.H. , Lack Nathan A. , Axerio-Cilies Peter , Leblanc Eric , Tavassoli Peyman , Kanaan Natalia , Frewin Kate , Singh Kriti , Adomat Hans , Böhm Konrad J. , Prinz Helge , Guns Emma Tomlinson , Rennie Paul S. , Cherkasov Artem
Published: April 2023

PDF file, 122K.
Supplementary Table 1 from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder
Authors: Sutherland Mark , Gill Jason H. , Loadman Paul M. , Laye Jonathan P. , Sheldrake Helen M. , Illingworth Nicola A. , Alandas Mohammed N. , Cooper Patricia A. , Searcey Mark , Pors Klaus , Shnyder Steve D. , Patterson Laurence H.
Published: April 2023

PDF file - 85k, Expression of CYP1A1 protein in human transitional cell carcinoma (TCC) of the bladder by immunohistochemical analyses.
Supplementary Figure 4 from Characterization of a New Class of Androgen Receptor Antagonists with Potential Therapeutic Application in Advanced Prostate Cancer
Authors: Li Huifang , Hassona Mohamed D.H. , Lack Nathan A. , Axerio-Cilies Peter , Leblanc Eric , Tavassoli Peyman , Kanaan Natalia , Frewin Kate , Singh Kriti , Adomat Hans , Böhm Konrad J. , Prinz Helge , Guns Emma Tomlinson , Rennie Paul S. , Cherkasov Artem
Published: April 2023

PDF file, 2136K, (A) Effect of VPC-3022 on AR activity in HeLa-AR cells in the presence of cyclohexamide. HeLa-AR cells were treated with serially-diluted concentrations of VPC-3022 (0 - 100 ?M) with or without 10 ?M of cyclohexamide for 8 hours, and then lysed with passive lysis buffer. (B) AR degradation caused by VPC-3031 and VPC-3041 in HeLa-AR cells. HeLa-AR cells were treated by VPC-3031 and VPC-3041 at different concentrations in the presence of 0.1 nM R1881.
Supplementary Figure 4 from Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer
Authors: Kumano Masafumi , Furukawa Junya , Shiota Masaki , Zardan Anousheh , Zhang Fan , Beraldi Eliana , Wiedmann Romina M. , Fazli Ladan , Zoubeidi Amina , Gleave Martin E.
Published: April 2023

PDF file - 93K, Inhibition of OGX-427-induced autophagy using chloroquine enhances cell apoptosis in LNCaP cells
Supplementary Figure S5 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer
Authors: Damiano Jason S. , Rendahl Katherine G. , Karim Christopher , Embry Millicent G. , Ghoddusi Majid , Holash Jocelyn , Fanidi Abdallah , Abrams Tinya J. , Abraham Judith A.
Published: April 2023

PDF file - 53KB, Effect of LFA102 monotherapy on DMBA tumor growth
Supplementary Figure S3 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer
Authors: Damiano Jason S. , Rendahl Katherine G. , Karim Christopher , Embry Millicent G. , Ghoddusi Majid , Holash Jocelyn , Fanidi Abdallah , Abrams Tinya J. , Abraham Judith A.
Published: April 2023

PDF file - 113KB, Effect of LFA102 on serum PRL levels in rats
Supplementary Figure S1 from Neutralization of Prolactin Receptor Function by Monoclonal Antibody LFA102, a Novel Potential Therapeutic for the Treatment of Breast Cancer
Authors: Damiano Jason S. , Rendahl Katherine G. , Karim Christopher , Embry Millicent G. , Ghoddusi Majid , Holash Jocelyn , Fanidi Abdallah , Abrams Tinya J. , Abraham Judith A.
Published: April 2023

PDF file - 49KB, Cell line PRLR expression by WB
Supplementary Figure 2 from CK2 Inhibitor CX-4945 Suppresses DNA Repair Response Triggered by DNA-Targeted Anticancer Drugs and Augments Efficacy: Mechanistic Rationale for Drug Combination Therapy
Authors: Siddiqui-Jain Adam , Bliesath Joshua , Macalino Diwata , Omori Mayuko , Huser Nanni , Streiner Nicole , Ho Caroline B. , Anderes Kenna , Proffitt Chris , O'Brien Sean E. , Lim John K. C. , Von Hoff Daniel D. , Ryckman David M. , Rice William G. , Drygin Denis
Published: April 2023

PDF file - 148K, The effects of CK2, MDC1 or XRCC1 depletion by siRNA on Gamma-H2AX levels induced by cisplatin or gemcitabine.
Supplementary Figure Legend from IGF-1R/MDM2 Relationship Confers Enhanced Sensitivity to RITA in Ewing Sarcoma Cells
Authors: Di Conza Giusy , Buttarelli Marianna , Monti Olimpia , Pellegrino Marsha , Mancini Francesca , Pontecorvi Alfredo , Scotlandi Katia , Moretti Fabiola
Published: April 2023

PDF file, 44KB.
Supplementary Figure 4 from Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer
Authors: Song Bing , Liu X. Shawn , Rice Steven J. , Kuang Shihuan , Elzey Bennett D. , Konieczny Stephen F. , Ratliff Timothy L. , Hazbun Tony , Chiorean Elena G. , Liu Xiaoqi
Published: April 2023

PDF file - 30k, knock-down of cFos and MDR1 by RNAi in gemcitabine-resistant cells
Supplementary Figure 3 from Plk1 Phosphorylation of Orc2 and Hbo1 Contributes to Gemcitabine Resistance in Pancreatic Cancer
Authors: Song Bing , Liu X. Shawn , Rice Steven J. , Kuang Shihuan , Elzey Bennett D. , Konieczny Stephen F. , Ratliff Timothy L. , Hazbun Tony , Chiorean Elena G. , Liu Xiaoqi
Published: April 2023

PDF file - 67K, Orc2-A and Hbo1-A mutant cells are sensitive to gemcitabine treatment
Supplementary Methods from Novel Immunotherapy for Malignant Melanoma with a Monoclonal Antibody That Blocks CEACAM1 Homophilic Interactions
Authors: Ortenberg Rona , Sapir Yair , Raz Lee , Hershkovitz Liat , Ben Arav Ayelet , Sapoznik Sivan , Barshack Iris , Avivi Camila , Berkun Yackov , Besser Michal J. , Ben-Moshe Tehila , Schachter Jacob , Markel Gal
Published: April 2023

PDF file, 55KB.