bluuebunny/crossref_metadata_2025 huggingface dataset:
THE CONCEPT OF “SPACE” IN THE KAZAKH WORLDVIEW
Authors: Iskakova А.
Published: January 2025

The article is devoted to the study of the concept of space in the worldview of the Kazakhs. Space, as a TILTANYM №4 (96) 2024 81 universal category of human thought characteristic of all ethnic groups and eras, is examined across various fields of scientific knowledge such as mathematics, physics, geography, philosophy, and linguistics. The concept of space in the article is analyzed within the consciousness of Turkic peoples, particularly in the mentality of the Kazakhs, over an extended historical period. The purpose of the article is to explore the peculiarities of how space is perceived and understood by the Kazakh people through the analysis of a literary work. The analysis is based on Ilyas Yesenberlin’s trilogy ”Nomads”, where attention is drawn to key lexical markers of Turkic nomadic culture, such as “steppe,” “land,” and “road” (“path”). The semantic analysis of these lexical markers reveals their polysemy, showcasing various aspects of how space is understood in the consciousness of the Kazakh people. Some of these markers contain sememes that express dynamism, movement, and the vastness of space. As a result of the study, it was concluded that in the Kazakh worldview, space represents a fundamental universal category closely associated with the traditional nomadic way of life and movement through space, which is undoubtedly shaped by the historical lifestyle of the Kazakhs and their habitation in the vast steppe.
THE «BEREKE» CONCEPT IN THE KAZAKH LINGUISTIC PICTURE OF THE WORLD
Authors: Onalbayeva А. , Kiynova Zh.
Published: January 2025

Recent linguistic research is aimed at studying the role and place of linguistic units in the human conceptual sphere, and much attention is paid to the linguistic and cultural aspect of language. The comprehensive study of a certain linguistic culture expands the horizons of understanding, contributing to a deeper understanding of the worldview of the people. And the exchange of information and values in intercultural communication promotes mutual understanding and broadens the horizons of each culture. The ethnospecific concept «Bereke» was chosen as the object of research, since it is culturally significant for native speakers, native and developing, which reveals the nature of the linguistic and cultural code of the language. The concept of «Bereke» is considered as a linguistic and cultural code that combines national cultural and value aspects. The concept of «Bereke» in Kazakh culture is multi-layered and multi-valued. His research allows for a deeper understanding of the cultural, social and historical features of Kazakh culture. This concept embodies important aspects of Kazakh life such as unity, well-being, connection with nature and spiritual wealth. The research work was carried out on the material of the National Corpus of the Kazakh language, and data from lexicographic sources were also used.
Hemolytic activity of saponins from the leaves and stems of the specie Boldoa purpurascens Cav., determined by HPLC – UV: Validation of the method
Authors: González-Mosquera Dulce María , Hernández-Ortega Yannarys , Orellana-Rodríguez Eliannet , Ojeda-González Idalmis Karina , Gigante-Silva Matheus , Quero-Jiménez Pedro César
Published: January 2025

This research contributes on the chemical composition of the species Boldoa purpurascens Cav. although the identification, quantification, and hemolytic activity evaluation of saponins isolated from this specie, moreover,  high-performance liquid chromatography - ultraviolet detection (HPLC - UV) methodology has been developed and validated. To determine the saponin content of Boldoa purpurascens Cav. hydroalcoholic extract, a HPLC – UV was used. A Quil-A® pattern has been used to evaluate the validation parameters, such as method linearity, limits of detection and quantification, precision, accuracy, selectivity, and specificity. The research showed that each target component was well-separated under the optimal analytical settings with great selectivity. The technique was found to be precise, accurate, and repeatable. The method's linearity was determined to be robust, with an excellent determination coefficient value (R2≥0.999). The evaluation of the matrix effect revealed that each target component had a high degree of selectivity and was well-separated. It could be inferred that the established HPLC-UV methodology is accurate and useful for identifying saponins in the hydroalcoholic extract of Boldoa purpurascens Cav. The hydroalcoholic extract of Boldoa purpurascens Cav. was used to quantitatively determine the saponin content, and it was discovered that the concentration of QS 7 in the 80% hydroalcoholic extract was 1.9 x 10-2 g L-1 in the stem whereas 1.6 x 10-2 g L-1 in the leaves. The Boldoa purpurascens Cav. saponins have hemolytic activity comparable to Quil-A®, as shown by a thin layer chromatographic hemolysis experiment.
Chemical composition, antioxidant and antimicrobial activities of the essential oil of Eudema nubigena Humb. & Bonpl.
Authors: Moncayo-Molina Luis , Rojas-Molina Jaime O. , Pino Jorge A. , Spengler Iraida , Moncayo-Rivera Christian M.
Published: January 2025

The chemical composition, antioxidant and antimicrobial activities of the essential oil from the aerial parts (leaves and flowers) of Eudema nubigena Humb. & Bonpl. were analyzed. The analysis of the essential oil was done by gas chromatography with flame ionization detector (GC-FID) and gas chromatography with mass spectrometry detector (GC-MS). A total of 131 compounds, representing 99.2% of the essential oil, were identified. The chemical profile revealed a high content of oxygenated monoterpenes (37.8%), monoterpene hydrocarbons (27.7%) and aliphatic compounds (17.3%). The major compounds were camphor (19.5%), myrcene (11.3%) and undecan-2-one (10.2%). The antioxidant activity of the essential oil, evaluated by DPPH and ABTS assays, exhibited a weak ability in scavenging radicals.  The essential oil also showed a low ferric reducing activity. The essential oil exhibited good activity against C. albicans, but low activities against S. aureus, E. coli, S. enterica serovar, and P. aeruginosa.
Antagonistic effect of the anaerobic co-digestion of thermoalkaline pretreated press mud fractions with vinasse
Authors: López González Lisbet Mailin , Pereda Reyes Ileana , Espinosa Negrín Ana María , Romero Romero Osvaldo
Published: January 2025

As a result of their activities, the sugar and ethanol industries generate large quantities of waste with high levels of organic matter. Two good examples are sugarcane press mud and vinasse (V), both with a great potential for biogas production. The geographical proximity of the aforementioned industries offers an opportunity to evaluate their anaerobic co-digestion behaviour. In this study, liquid fractions (LF) and solid fractions (SF) from lime (Ca(OH)2) pretreated press mud (at 100°C), were mixed with V following a three factor mixture design, in order to evaluate synergistic and antagonistic effects on methane yield. The methane yield was determined in batch assays under mesophilic conditions (37 ± 1 °C). The Hill model was used to determine the maximum methane yield, and the specific methane production rate. Synergistic, antagonistic or unclear effects were included in a parameter phi (∅), for evaluation of the co-digestion. Experimental results showed antagonistic effects for nearly all mixture combinations (∅ < 1). However, for the mixture SF-V when SF>V, the effect was synergistic (∅ > 1). Thus far in terms of methane yield and process kinetics, anaerobic co-digestion of the mixtures has not been found to be a better option than the digestion of the separate components.
Two treatises of government de Locke e de L'esprit des Lois de Montesquieu: contribuições e relações recíprocas para a divisão do poder político no pensamento liberal
Authors: Morais Salomão Saraiva de , Veloso Roberto Carvalho
Published: January 2025

Esta pesquisa possui como objeto investigar a interação trazida na linguagem ideológica liberal clássica das obras Two Treatises Government (1689) de John Locke e De L'esprit des Lois (1748) de Barão de Montesquieu, encaradas como construção epistemológica essencial para a ciência política e teoria geral do Estado, tendo fim inferir para conhecer pontos de ressonância e dissonância quanto a percepção liberal acerca da divisão horizontal do poder político. Empregou-se o raciocínio dialético, com acesso a pesquisa bibliográfica, partindo (tese) das contribuições das obras Two Treatises Government e De L'esprit des Lois, segundo suas definições acerca do estado de natureza, leis, direito natural, liberdades políticas, sociedade civil, formas de governo, Governo Civil, pacto social e limitação do poder estatal, para num segundo momento (antítese) em nível mediador, emergir aspectos de convergência e divergência extraídos das obras objeto de exame, para alcançar em grau de síntese a estabilidade conciliadora acerca da separação dos poderes, como técnica eficaz para limitação do poder político.
BLOCKCHAIN TECHNOLOGY IN ACCOUNTING: A STUDY ON THE PERCEPTION OF CAs IN AHMEDABAD
Authors: Prajapati Mahendra
Published: January 2025

Blockchain technology holds significant promises for transforming the accounting profession by addressing key challenges such as fraud, transparency, and efficiency. One of the most profound impacts of blockchain in accounting is its ability to create an immutable and transparent ledger of financial transactions. This study explores the perceptions of Chartered Accountants (CAs) in Ahmedabad towards the adoption of blockchain technology in accounting. The research objectives include analyzing the perceptions of CAs regarding blockchain and investigating the association between their demographic profiles—such as age, years of experience, and occupation—and their views on blockchain adoption. A total of 150 CAs from Ahmedabad were interviewed to gather insights on these aspects. The findings indicate that CAs generally perceive blockchain as a transformative tool that can significantly improve transparency and reduce fraud in accounting. Additionally, the study identifies a clear association between the demographic factors of CAs and their perceptions of blockchain technology, suggesting that age, experience, and professional role influence their openness to adopting this emerging technology.
Literary Code-Switching and Beyond : With an essay by Sabira Ståhlberg and an interview with Mohcine Ait Ramdan
Authors: Domokos Johanna , Deganutti Marianna
Published: January 2025

This monography delves deep into the realms where diverse linguistic and artistic codes converge to shape the very essence of aesthetic experience. From the authorial motivations to the composition, narrative framework, functional aspects, and multimodal manifestations, it unravels the complexities of code-switching as a powerful aesthetic device. Drawing from a rich tapestry of literary and artistic works, it explores how code-switching transcends linguistic boundaries to create captivating narratives and immersive artistic experiences. The outlined multidimensional approach goes beyond mere linguistic analysis, delving into the intricate interplay of semiotic resources, cultural contexts, and narrative strategies. Through meticulous examination and insightful case studies, it sheds light on the multifaceted nature of aesthetic code-switching, revealing its profound impact on artistic expression and communication. As you embark on this journey, this monography invites you to explore the diverse landscapes of aesthetic multilingualism, where words, sounds, and visuals converge to create art that transcends linguistic and cultural boundaries and captivates the imagination.
Lipoma of the tongue – an uncommon location for a tumor
Authors: Bohdziewicz Anna , Wiśniewska Julia , Piskadło-Zborowska Karolina , Dżaman Karolina
Published: January 2025

Introduction: The tongue, a complex organ essential for various functions such as speech and mastication, is predisposed to the development of tumors or other various lesions, though such occurrences are relatively rare. Intraoral lipomas, particularly those located on the tongue, are very uncommon.Case study: This report presents a case involving a 48-year-old male patient who presented with a painless swelling on the tongue, subsequently diagnosed as a spindle cell lipoma. The diagnostic process included a thorough physical examination and ultrasound imaging, ending in the surgical excision of the lesion. Histopathological examination confirmed the diagnosis of spindle cell lipoma.Conclusions: The infrequency of intraoral spindle cell lipomas emphasizes the necessity for accurate diagnosis and effective management strategies. The pathogenic mechanisms implicated in the development of intraoral lipomas are varied, encompassing theories related to obesity, metaplasia, and previous trauma. Treatment generally consists of surgical excision; however, new nonsurgical treatment modalities are currently under investigation. Our case highlights the significance of advanced diagnostic techniques and innovative treatment approaches.
Laryngeal Sarcomas: A Meta-Analysis of Diagnostic and Therapeutic Approaches Based on 84 Patients from Two Leading Centers in Poland
Authors: Składzień Jacek , Bruzgielewicz Antoni , Tomik Jerzy , Kocoń Sebastian , Niemczyk Kazimierz
Published: January 2025

Introduction: Over 98% of all malignant laryngeal cancers are squamous cell carcinomas. Other malignant tumors of the larynx are extremely rare, leading to non-squamous laryngeal cancer patients often receiving improvised treatment. Treatment protocols from other organs are applied, without considering the specific types of surgeries for the larynx. Currently, there is a lack of data on the optimal treatment of primary laryngeal sarcomas.Aim: This study aims to optimize the treatment of laryngeal sarcoma patients, focusing on differences in diagnostic and therapeutic approaches in two oncology centers in Poland.Material and method: A meta-analysis of patient records with laryngeal sarcomas treated between 2000 and 2019 at the Otolaryngology Departments of Jagiellonian University in Kraków and Warsaw Medical University was conducted. Various sarcoma types and diagnostic approaches, including PET, CT, and ultrasound imaging, were analyzed.Results: Over the study period, 84 patients were treated. The most common sarcomas were carcinosarcoma (22), chondrosarcoma (13), and synovial sarcoma (10). Most patients were over 65 years old, and all underwent surgical treatment with appropriate margins. Recurrences occurred in 11% of cases, with 13 patients dying due to distant metastases, primarily in bones.Discussion: The results indicate that while laryngeal sarcoma treatment is less standardized than for squamous cell carcinoma, the two centers applied similar diagnostic protocols. The routine use of PET imaging was identified as a critical improvement for therapeutic decision-making.Conclusions: Partial laryngectomy was found to be effective, with neck lymph node dissection required only for carcinosarcomas. PET imaging is strongly recommended for laryngeal sarcoma diagnostics.
Oral and Oropharyngeal Microbiome – Characteristics, Significance, and Potential Therapeutic Interventions
Authors: Ziuzia-Januszewska Laura , Zygało Jakub , Brożek-Mądry Eliza
Published: January 2025

The proper functioning of the human body largely depends on the microorganisms it hosts. The ecosystem formed by these microorganisms, along with their genome, the metabolites they produce, and the conditions in their environment, constitutes the microbiome. The microbiome plays a crucial role in regulating the host’s physiological, immunological, and metabolic functions. Changes in the composition of the microbiome can affect the occurrence and progression of both local conditions in the oral cavity and oropharynx, as well as systemic diseases. Therefore, it is essential to explore methods for modifying the microbiome’s composition and preventing the negative consequences of dysbiosis. Current research focuses on probiotics, prebiotics, dietary supplements, antibiotics, and chemotherapeutics. This review aims to summarize the knowledge regarding the oral and oropharyngeal microbiome, its significance for human health, and potential therapeutic approaches to influence this complex ecosystem.
EXPERIÊNCIA DE MÃES QUILOMBOLAS COM A VISITA DOMICILIAR NA PRIMEIRA SEMANA DE VIDA DO FILHO
Authors: Cunha Rafaela Domingos da
Published: January 2025

A atenção à saúde prestada às populações quilombolas está centrada prioritariamente na Atenção Primária à Saúde, e a Estratégia Saúde da Família exerce um papel importante na assistência à essa população, com destaque para a criança quilombola, a qual está exposta a inúmeros fatores de riscos e escassa condição de saúde que pode comprometer seu crescimento e desenvolvimento, contribuindo para a ocorrência da morbimortalidade infantil. A visita domiciliar, realizada pelos profissionais de saúde da família, desde a primeira semana de vida, é imprescindível para intervir nos possíveis riscos à vida do neonato. Objetiva-se analisar a experiência de mulheres quilombolas acerca da visita domiciliar realizada pelos profissionais de saúde na primeira semana de vida do filho, como também a assistência à saúde realizada pelos profissionais ao binômio mãe/recém-nascido. Trata-se de uma pesquisa exploratório-descritiva, com abordagem qualitativa realizada em uma Comunidade Quilombola localizada em João Pessoa-PB. Perceberam-se lacunas na assistência dos profissionais de saúde ao binômio mãe-recém-nascido quilombola, evidenciada pela fragilidade do vínculo entre profissional e a família. Evidenciou-se dificuldade de acesso para o atendimento em saúde, tendo a distância entre o domicílio e a unidade de saúde a principal barreira no acesso, como também, as mães não percebem um cuidado acessível e resolutivo ao seu problema na Estratégia Saúde da Família.
Natural catalysts for a sustainable future
Authors:   Technical University of Denmark, Woodley John
Published: January 2025

As natural and biodegradable agents, enzymes are key to advancing sustainable, green manufacturing practices across diverse sectors. These natural proteins/catalyst facilitate oxidation reactions by transferring oxygen or electrons and speed up oxidation reactions so that a wide variety of products can be made without using high temperatures or harsh chemicals, as Professor John Woodley explains
TECHNICAL ANALYSIS OF HARTMANN’S RETROSIGMOIDECTOMY IN THE EMERGENCY CONTEXT OF COMPLICATED DIVERTICULITIS HINCHEY III AND IV
Authors: Cardoso Leone Romagnoli , Mota Gabriel Gonçalves Bastos , Guedes Emmanuelly Martins , Santiago Diego dos Passos , Hildefonso Diogo Mariano , De Lima Thaíse Ferreira Carneiro , Nogueira Camille Silva , Pedrosa Marcelle Lopes Tavares , Jácome Letícia Cristina de Souza , Santos Paula Fernanda de Araújo Lima , Cortes Karol da Conceição Rabello , Lopes Anaísa Filmiano Andrade , Brasil Tatiana Lima , Neto José Edson de Moura , Almeida João Victor Fabris , Barros Dimitri Mota , Rodrigues e Souza José Vitor , Alves Samuel Andrade Farias , Uliano José Vitor , Junior Marcello Laporta Carlos
Published: January 2025

Hartmann’s retrosigmoidectomy is a widely adopted surgical procedure for managing patients with complicated diverticulitis, particularly in Hinchey III and IV stages. These advanced stages are associated with high morbidity and mortality due to purulent or fecal peritonitis, necessitating emergent surgical interventions. This study presents a systematic technical analysis of Hartmann’s procedure in this emergency context, focusing on outcomes such as mortality, morbidity, stoma reversal rates, and long-term complications. A comprehensive search was conducted in PubMed, Embase, Cochrane Library, and Scopus for studies published between 2016 and 2024, using keywords like "Hartmann’s Procedure," "Complicated Diverticulitis," "Hinchey III and IV," and "Emergency Surgery." Of 34 initially identified studies, 10 met the inclusion criteria. Findings reveal that while Hartmann’s procedure remains a vital option for hemodynamically unstable patients, its limitations, such as low stoma reversal rates (43.9%, Facile et al., 2020) and higher long-term complication rates, underscore the need for patient stratification. Comparatively, primary anastomosis demonstrated superior outcomes in selected stable patients, with higher stoma reversal rates (86.9%, Bridoux et al., 2017) and improved quality of life. Advances in laparoscopic approaches have also shown potential in enhancing outcomes for Hartmann’s procedure. Despite its established role, the procedure’s high morbidity and low reversal rates prompt the need for further research into individualized patient selection and innovative surgical techniques.
Corporate Governance, Management Control System and Financial Performance of State-Owned Enterprises in Tanzania
Authors: Matutu Marungwa R. ,   University of Dar es Salaam, Chalu Henry ,   University of Dar es Salaam
Published: January 2025

The aim of this paper was to investigate the mediating role of the Management Control System in the relationship between Corporate Governance and the Financial Performance of State-Owned Enterprises in Tanzania. Data were gathered from board members through questionnaires, resulting in a sample of 50 State-Owned Enterprises with 300 respondents. Agency and Contingency theories were employed to explain the effects of the interdependence between Corporate Governance and Management Control System on firm performance.
The data were analysed using PLS-SEM, revealing that corporate governance significantly enhances management control systems, which subsequently positively affects the financial performance of state-owned enterprises. However, Corporate Governance and Financial Performance were found to be negatively related. Additionally, Management Control System serves as a mediator in the
linkage between Corporate Governance and Financial Performance in Tanzanian State-Owned Enterprises.
The findings had practical relevance for boards of directors, Chief Executive Officers, and the Treasury Registrar, assisting them in utilizing Corporate Governance and Management Control System to develop strategies for improving State-Owned Enterprises financial performance. Prior research on the linkage between corporate governance and financial performance did not include Management Control System as a mediating variable, making. The current study fills this gap and adds to the body of literature. However, the findings apply only to commercial State-Owned Enterprises s and do not extend to non-commercial State-Owned Enterprises.

Keywords: Corporate Governance, Management Control System, financial performance, State Owned Enterprises
The Effect of Extrinsic Benefits of Online Shopping on Customer Behavioural Intentions in Tanzania: Moderating Role of Customer Satisfaction
Authors: Okangi Fred Phanuel ,   University of Dar es Salaam
Published: January 2025

The trend of individuals using the internet has been increasing over the years leading to the booming online shopping that has attracted academic researchers to investigate the motives or benefits of online shopping. This study aimed to elucidate the influence of extrinsic benefits (variety, price, and ease of use) on online shopping behavioural intentions, with customer satisfaction as a mediating role. A self-administered questionnaire was used to capture data from online shoppers in Tanzania. The data were analysed using Smart PLS 3 structural equation modelling. The results indicate that the extrinsic benefits significantly affect online customer behavioural intentions. Satisfaction fully mediates the effects of two dimensions of extrinsic benefits aspects (variety and
ease of use) on behavioural intentions. Extrinsic benefits also partially mediate the effects of price on behavioural intentions. The results provide insights into how online vendors can use strategic and tactical use of extrinsic benefits in leveraging their short- and long-term marketing strategies. The study affirms the utility and integration of the extrinsic benefits and the Uses and Gratifications
Theory in the context of online shopping.

Keywords: Extrinsic benefits, online shopping, satisfaction, behavioural intentions
Blended professional teaching of Internal Medicine in third-year medical students
Authors: Alonso Betancourt Luis Aníbal , Silva Velasco Edilio , Velázquez González Verónica Aleyda , Vidal Gámez Luis Enrique , Vidal Rodríguez Anisleidy , García González Maryuri , García Hernández Adelin
Published: January 2025

Introduction. Conceiving the teaching of Internal Medicine in the post-pandemic era in the third-year medical student presupposes taking into consideration the latest scientific and technological advances that operate in therapeutic diagnostic protocols for the solution of health problems, as well as the use of combined professional teaching methods (b-Professional Teaching) under the principle of affordability of content.Objective. To propose a methodology for combined professional teaching of Internal Medicine in third-year Medicine students. Methods: A cross-sectional quasi-experimental study was carried out. The population was made up of third-year medical students who rotate through the Hospital.Methods. A cross-sectional quasi-experimental study was carried out. The population was made up of third-year medical students who rotate through the “Vladimir Ilich Lenin” University General Hospital of Holguín. Groups 1 and 3 were selected as a sample because they presented similar results in their clinical training through intentional sampling, for a total of 54. Observation and the Wilcoxon Signed Rank Test were used to confirm the research hypothesis. Results. The combined professional teaching methodology of Internal Medicine was provided, as well as the main achievements and deficiencies that the Medical students demonstrated during the application of the same in a training period. Conclusions. The combined professional teaching of Internal Medicine is conceived through the affordability of the content according to the characteristics of the third-year student and is materialized through the link between thez academic, work and research component based on the integration of face-to-face and virtual teaching (virtual classrooms and mobile devices).
Clinical and epidemiological characterization of patients with ischemic heart disease and left ventricular dysfunction
Authors: Mesa Valiente Rita María , Turro Caró Eloy , Turro Mesa Lucia Nivia , Caballero Germán Del Río , Del Río Mesa Germán Ricardo , Montes de Oca Carmenaty Margarita
Published: January 2025

Introduction: One of the most common causes of heart failure is ischemic heart disease.  Objective: To characterize patients with a diagnosis of ischemic heart disease and left ventricular dysfunction from an epidemiological and clinical point of view.Methods: Observational, descriptive and cross-sectional study in a population of 300 patients with a diagnosis of ischemic heart disease and left ventricular dysfunction, treated in the cardiology service of the Saturnino Lora Torres Provincial Clinical Surgical Teaching Hospital, from January 2021 to December 2023. The summary measures were applied for each type of variable, in each statistical test a significance level α=0.05 was used. Results: 53.3% of the patients were in the age group of 60 to 79 years and 66.0% were male. A significant statistical association was found between the presence of pulmonary edema and systolic-diastolic dysfunction of the left ventricle; as well as cardiogenic shock, sustained ventricular arrhythmias, stroke and pulmonary embolism with the status at discharge. Conclusions: Patients with a diagnosis of ischemic heart disease and left ventricular dysfunction were characterized by advanced age, disparity in the proportion between sexes. The presence of pulmonary edema was secondary to systolic-diastolic dysfunction of the left ventricle. Patients with negative coronary angiography, cardiogenic shock, sustained ventricular arrhythmias, stroke, and pulmonary embolism were associated with discharge status.
Improvement strategy to improve the professional performance of family physicians in the care of the frail elderly
Authors: Mesa Valiente Rita María , Del Rio Caballero German , Hurtado Gascón Laura Caridad , Turro Mesa Lucia Nivia , Mesa German Ricardo del Río , Turro Caró Eloy
Published: January 2025

Introduction: The physiological process of aging leads to risk situations, including frailty, therefore, primary care professionals must achieve the necessary competence to face it successfully.Objective: To design an improvement strategy to improve the professional performance of the family physician in the care of the frail elderly.Method: A two-phase research was carried out: the first phase was descriptive, observational and mixed (quantitative-qualitative) to diagnose the performance status of the professionals, the population consisted of 28 family physicians. Four dimensions and 18 indicators were evaluated and their methodological triangulation was carried out to establish problems and potentialities. In a second phase of development and technological innovation, the principles of the proposed strategy, its modeling, design and main results are established and supported.Results: There is little evidence of professionals' mastery of the criteria of frailty, its symptoms and signs and therapeutic approach. It was also found low frequency of realization of health promotion activities and insufficient use of the instruments for multidimensional assessment, The overcoming strategy is modeled with four stages, each with specific objectives and actions to be developed.Conclusions: An insufficient performance of professionals in the comprehensive care of frail adults before applying the educational strategy is verified, in the comparative observations after its implementation, a remarkable improvement in performance and satisfaction is evidenced, which makes it possible to recognize the validity of the proposed strategy.
Immunological aspects of COVID-19 pathogenesis: a review
Authors: Miló Valdés Carlos Alfredo , Pérez Acevedo Lidia Cecilia
Published: January 2025

Introduction: COVID-19, caused by SARS-CoV-2, has challenged the scientific and medical community since its emergence. Understanding the immunopathogenic events that occur during infection is crucial to developing effective treatment and prevention strategies.Objective: To synthesize the immunological aspects in the pathogenesis of coronavirus disease 2019.Development: SARS-CoV-2 infection begins with the entry of the virus into host cells through the ACE2 receptor. Once inside, the virus induces an immune response. In the early stages, the innate immune response is activated, which includes the release of interferons and cytokines. However, in some patients, this response becomes deregulated, triggering a cytokine storm that contributes to systemic inflammation and lung damage. T and B cells also play a crucial role; although the activation of CD8+ T cells can help control the infection, their depletion in severe cases has been associated with worse clinical outcomes. Conclusions: Immunopathogenic events in COVID-19 are complex and can lead to diverse clinical outcomes. Understanding these mechanisms is essential for the development of targeted therapies and effective vaccines. Continued research is critical to improving our response to future pandemics.
Patients' characterization affected with cervicalgia assisted in the Services of Integral Rehabilitation
Authors: Borrero Terrero Yoanky , Vianka Lisandra González Montalván , Ordoñez  Álvarez Lázaro Yoan , González Sardabu Lidiuska Gladys , Hernández Ávila Frank
Published: January 2025

Introduction: the cervicalgia constitutes the clinical entity that refers to the pain located in the later region and posterolateral of the neck, from the occiput until the high dorsal region.  Objective: to characterize clinical and therapeutically the patients affected with cervicalgia assisted in the room of rehabilitation of the Center Diagnosis Integral School The Olive trees in the state of Bolivar, in the period of January to June 2024.  Methods: he/she was carried out an observational study, analytic of cohort, longitudinal and prospective that included the patients affected with cervicalgia assisted in the room of rehabilitation of the Center Diagnosis Integral School The Olive trees.  Results: in relation to the distribution of patient according to sex, it is observed that the feminine sex prevailed with 75,7%, the etiología of the most frequent cervicalgia in the individuals of the study was the mechanics with 73,6%.  Conclusions: they were characterized clinical and therapeutically the patients affected with cervicalgia assisted in the rehabilitation room where the women constitute the most representative sex, being more frequent the entity in the adult associated to mechanical causes
Immuno-nutritional and insulin-resistance markers associated with severe perioperative complications after cardiac surgery
Authors: el Río Caballero Germán , Turro Mesa Lucía Nivia , Del Río Mesa Germán Ricardo , Mesa Valiente Rita María , Turro Caró Eloy
Published: January 2025

Introduction: The progress of cardiac surgery that has been parallel to technological development has not been able to sufficiently counteract the high morbidity and mortality of cardiovascular surgical patients and their high costs; for this reason, the search for markers that can predict adverse effects and post-surgical complications in time and facilitate a better evaluation of these patients continues. Objective: to evaluate the degree of association of new immuno-nutritional and insulin-resistance biomolecular markers with the appearance of serious perioperative complications.Methods: An ambispective cohort study was carried out on patients who underwent major cardiovascular surgery between January 1, 2019 and December 31, 2023 at the Cardiocentro of Santiago de Cuba, who met inclusion criteria. Results: A significant association was found between immuno-nutritional and insulin resistance biomarkers and severe perioperative complications: triglyceride-glycemia index (p=0.000 RR 5.23), leuko-glycemic index (p=0.000 RR 7.76), nutritional prognostic index (p=0.004 RR 2.56), albumin/globulin ratio (p=0.050 RR 0.338).Conclusions: A close link is demonstrated between the new biomarkers selected and severe perioperative complications, so their inclusion in the preoperative assessment could facilitate earlier monitoring, diagnosis and treatment of complications and reduce morbidity and mortality in these patients
Strategy of professional superacion on Natural and Traditional Medicine in the Primary Attention of Health
Authors: Blanco Fuentes Rosa Marila , Ramos Vives Madelaime , Ramos Padilla Kenia , García Pérez Marleidy , Soberao Rodríguez Lidiana
Published: January 2025

Introduction: In Cuba, where it is high-priority the Primary Attention of Health, you intenciona a system of permanent superación directed to the professionals to guarantee the quality of the service of health, from this perspective, the concept superación of the primary attention of health is identified many times with training, formation and development.   Objective: to elaborate a strategy that contributes to the improvement of the process of professional superación on Natural and Traditional Medicine in the Primary Attention of Health that allows the specialist's efficient acting in Family Medicine in the Policlínico University Siblings Cruz of Pinegrove of the River. Methods: the investigation was sustained in the materialistic dialectical focus that bases the study of the object like process, and that it allowed to deepen in the knowledge of the object and its interrelations under the social historical conditions of the graduate degree education it has more than enough Natural and Traditional Medicine in the specialist in Family Medicine, to reveal its main contradictions, to select, to base and to integrate the theoretical, empiric and statistical methods. The selected variable is process of professional superación on Natural and Traditional Medicine.  Results: the strategy of professional superación is presented on Natural and Traditional Medicine in the primary attention of health with base in the theoretical and empiric derivations of the investigative process and starting from foundations sustained in different areas of the knowledge, they intend the structure, characteristics, components and relationships for the process in study and its theoretical validation.  Conclusions: in the strategy of professional superación on Natural and Traditional Medicine in the primary attention of health the purposes were summed up to achieve the specialist's efficient acting in Family Medicine, in the transformation of the reality in the area of health of the Policlínico University Siblings Cruz of Pinegrove of the River
Didactic pamphlet for the work with the address abilities from the docencia
Authors: González Sardabu Lidiuska Gladys , Ordoñez  Álvarez Lázaro Yoan , Curbelo Fajardo Juan Carlos , Ramírez Pérez Noelvis , Gil Figueroa Bertha Vivian
Published: January 2025

Introduction: the formation and development of the squares should be conditioned for political and strategies of the organization. The public health, needs that the preparation and the development of their directive are in function of responding to the necessities of the plans, programs and national strategies of health.   Objective: to implement a didactic pamphlet that he/she responds to the necessity of training of the squares and reservations in the Cuban medical mission in Venezuela, state of Bolivar. Development: the present investigation, takes like methodological base of the scientific knowledge, to the dialectical-materialistic method serving from base to the objective character of the inquiry process científica.La validation and implementation of the pamphlet like didactic tool to use in the courses and training of squares and reservations, approach was obtained of good for 93,2% of the total of experts.  Conclusions: with their implementation a logical order of the actions that requires the preparation of the educational ones that you/they impart the training of the squares and reservations in the Cuban medical mission in Venezuela, state of Bolivar starting from the foundations and approaches emitted by the indexed investigators, settled down as well as the amplification of essential components of the knowledge that you contextualizan in the current realities
Relationship between social media marketing and millennials' purchase decision
Authors: Uyejara-López Mayumi , García-Rodríguez Carlos Javier , Murga-Montoya José Elías , Cárdenas-García Ángel , Terrones-Suarez Orlando
Published: January 2025

Social media marketing has become an essential tool to influence consumer purchasing decisions. This study aimed to analyze the relationship between social media marketing and millennials' purchasing decisions. A quantitative approach was used, with a non-experimental, correlational and cross-sectional design, applying surveys to 379 customers. The data were analyzed using Spearman's correlation coefficient. The results revealed a significant and strong correlation between social media marketing and the purchasing decision (rho=0.749, p<0.001). In addition, it was found that the dimensions entertainment (rho=0.742) and interaction (rho=0.752) had a high influence on the purchasing decision. It is concluded that social media marketing strategies directly impact purchasing decisions, which highlights their importance in the current business environment.
Top team effectiveness and how to develop it
Authors: Beer Michael
Published: January 2025

Top team effectiveness and how to develop it

Dr Michael (Mike) Beer, Professor Emeritus from Harvard Business School, explains top team effectiveness and how to develop it. Organizations have tops, middles, bottoms, and customers. (1) They are hierarchies that must serve customers well to survive and prosper. The role of top teams is to define the enterprise’s strategic direction and ensure it is organized, managed, and led to execute that direction effectively. Yet, top teams too often do not fulfill their role effectively. We know this from 30 years of work with hundreds of organizations whose leaders have come to me and my colleagues at TruePoint, a consulting firm composed of scholar-consultants, for help.
Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence
Authors: Shew Matthew , Buchman Craig A , Walia Amit
Published: January 2025

Predicting cochlear implant performance: Moving beyond single biomarkers and leveraging artificial intelligence

Matthew Shew, Amit Walia, and Craig A. Buchman highlight that the significant variability in speech perception among cochlear implant users can be addressed by using a multi- faceted approach that incorporates emerging technologies like machine learning and artificial intelligence to improve outcome prediction models. Cochlear implants (CIs) represent one of the most successful neural prostheses, providing discrete frequency and intensity electrical stimulation to restore hearing, improve speech understanding, and enhance quality of life. Despite their transformative impact, a significant challenge remains: the substantial variability in speech perception outcomes among CI users. (1) While current methodologies excel at identifying individuals with severe hearing loss and, thus, strong CI candidates, they fall short in predicting the degree of benefit each recipient will gain from the device. This limitation hinders personalized care and underscores the need for more advanced predictive tools.
The future of green tech: Self-powered IoT sensors
Authors: Staaf Henrik
Published: January 2025

The future of green tech: Self-powered IoT sensors

Discover the future of green technology and self-powered IoT sensors, as explained by Henrik Staaf from RISE Research Institutes of Sweden. As sustainability becomes a global priority, self-powered Internet of Things (IoT) sensors are transforming the way technology integrates with our lives. These innovative devices harvest energy from their surroundings, allowing them to function without batteries. This breakthrough not only enables real-time monitoring but also significantly reduces environmental impact, paving the way for smarter, greener systems.
Echo’s citizen science initiatives for soil literacy take off
Authors: Peiro Alba , Cappello Claudia , Laurent Céline , Sanz Francisco , Papadopoulou Elisavet , Mimmo Tanja
Published: January 2025

Echo’s citizen science initiatives for soil literacy take off

Led by ECHO partners, we hear about citizen science initiatives that aim to improve soil literacy and foster sustainable practices through workshops and community engagement. Citizen science has a long-standing history across Europe as a significant tool for addressing environmental issues by raising awareness and promoting best practices. Over the past 15 years, citizen science projects focusing on soils have gained significant traction, driven by a growing awareness of environmental issues and the integration of soil health into political agendas. A key initiative in this direction is the European Soil Observatory (EUSO), a platform that monitors soil health and related policies to enhance soil protection. It integrates soil health data that can be further enriched by citizen-generated data collected through citizen science initiatives, such as the European project ECHO.
Decarbonising the textile industry: A revolutionary pigment from the lab to the market in three years
Authors: Durand Victor
Published: January 2025

Decarbonising the textile industry: A revolutionary pigment from the lab to the market in three years

Explore the journey of decarbonising the textile industry through the remarkable example of bringing a revolutionary pigment from the lab to the market in three years, starting with the milestones of this captivating journey. EverDye is a green chemistry startup aiming at decarbonizing the way we colour our garments. Its journey began with a vision to revolutionise textile dyeing, one of the most impactful steps of textile production. Along the way, the company achieved milestones that validated the impact and scalability of its innovation. Each step marked a significant leap toward creating a sustainable solution for the textile industry, free from intensive resource utilisation.
Understanding electromagnetic hypersensitivity (EHS)
Authors: Bevington Michael
Published: January 2025

Understanding electromagnetic hypersensitivity (EHS)

Electromagnetic hypersensitivity: Michael Bevington, Chair of Trustees at Electrosensitivity UK, explains the health risks associated with exposure to radiofrequency radiation and electromagnetic fields and why more robust action is needed to protect public health. Electromagnetic Hypersensitivity (EHS) is a physical reaction to radiofrequency radiation (RFR) and electromagnetic fields (EMFs). These come from mobile phone masts, mobile phones, Wi-Fi, Bluetooth, smart meters, and similar devices, as well as power lines and electric motors. Typical short-term symptoms are headaches, dizziness, brain fog, memory loss, muscle pains, heart palpitations, anxiety, depression, nosebleeds and skin rashes. Long-term symptoms, often subconscious, range from cancer and infertility to neurological and cardiovascular harm.
New strategies for an old problem - Oral vaccines research
Authors: Norton Elizabeth B
Published: January 2025

New strategies for an old problem - Oral vaccines research

Despite their advantages, oral vaccines encounter several challenges. Professor Elizabeth Norton from Tulane University discusses how her team is addressing these issues and their research on developing and testing dmLT and saponin combination adjuvants. The gut is home to a remarkable concentration of the body’s immune cells, particularly antibody-secreting plasma cells. It serves as a critical site for interactions with microbes, exposure to pathogens, and maintaining overall health. Globally, several human vaccines leverage oral delivery routes due to their ability to stimulate mucosal immunity and suitability for mass immunization campaigns. (1) Notable licensed oral vaccines include live-attenuated vaccines for polio, rotavirus, Salmonella typhi, and adenovirus, as well as whole-inactivated vaccines for cholera. These vaccines offer additional benefits, such as eliminating the need for syringes and needles. This is particularly valuable in resource-limited settings, where needle reuse can lead to accidental transmission of bloodborne infections like HIV and hepatitis, and it also mitigates needle-related aversion among individuals.
Forging unity: Interagency collaboration in hybrid warfare
Authors: Mattingsdal Jostein
Published: January 2025

Forging unity: Interagency collaboration in hybrid warfare

Jostein Mattingsdal explores leadership’s critical role in maximizing interagency collaboration’s effectiveness in hybrid warfare scenarios. Hybrid warfare challenges traditional security paradigms by blurring the distinctions between war and peace, combatants and non-combatants, and military and civilian domains. (1) It can be conducted by both state and non-state actors to achieve strategic objectives and manifests in various forms. It can include disinformation campaigns designed to erode public trust, subversion tactics aimed at destabilizing nations, and overt combat actions disrupting national sovereignty. Addressing these threats requires a coordinated response that harnesses the operational capabilities of different agencies. (2) However, conventional mindsets among key leaders can hinder this essential collaboration, emphasizing the need for a shift toward embracing the cross-sectoral advantages of collaborative efforts.