bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipidomics Study of the Therapeutic Mechanism of Plantaginis Semen in Potassium Oxonate-Induced Hyperuricemia Rat
Authors: Shi Wenjun , Yang Fei , Wang Liting , Qin Nankun , Wang Chengxiang , Xu Guang , Guo Yuying , Yu Xue , Ma Qun
Published: November 2020

BackgroundPlantaginis semen has been widely used as folk medicine and health care food against hyperuricemia (HUA) and gout, but little was known about its pharmacological mechanism. MethodsThe model was established by potassium oxonate intragastric administration. 42 Sprague-Dawley (SD) male rats were randomly divided into the control group, model group, benzbromarone group (10 mg/kg) and three Plantaginis semen groups (n = 7). The Plantaginis semen groups were treated orally with Plantaginis semen at 0.9375, 1.875 and 3.75 g/kg for 28 days. The levels of serum uric acid (UA), creatinine (Cr), triacylglycerol (TG) and tumor necrosis factor-α (TNF-α) were detected using enzyme-linked immunosorbent assay kits. Ultra performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF/MS) was used as the basis for serum lipidomics analysis, and orthogonal partial least squares discriminant analysis (OPLS-DA) was carried out for the pattern recognition and characteristic metabolites identification. The relative levels of critical regulatory factors of urate anion transporter 1(URAT1) and phosphatidylinositol 3-kinase/ protein kinases B (PI3K/Akt) were determined by quantitative real-time polymerase chain reaction (RT-qPCR). ResultsCompared with the model group, the levels of serum UA, Cr, and TG were significantly (p<0.01) decreased in benzbromarone and three Plantaginis semen groups and the level of serum TNF-α was significantly (p<0.05) decreased in benzbromarone and low dose of Plantaginis semen group. With lipidomics analysis, significant lipid metabolic perturbations were observed in HUA rats, 13 metabolites were identified as potential biomarkers and glycerophospholipid metabolism pathway was mostly affected. These perturbations can be partially restored via treatment of benzbromarone and Plantaginis semen. Additionally, the URAT1 and PI3K/Akt mRNA expression levels were significantly decreased (p<0.05) after treatment with benzbromarone and high dose of Plantaginis semen. ConclusionsPlantaginis semen had significant anti-HUA, anti-inflammatory and renal protection effects and could attenuate potassium oxonate-induced HUA through regulation of lipid metabolism disorder. Trial registrationNot applicable
A Framework for the Implementation of Certification Procedures at Nurse Level: A Case Study in a French Hospital.
Authors: SALMA Israa , WAELLI Mathias
Published: November 2020

Background: The implementation of certification procedures across healthcare systems is an essential component of the management process. In the past, several promising approaches have been developed towards the successful implementation of such policies, however, precise adaptation and implementation at the local context is essential. Thus, local activities must be considered to generate more pragmatic recommendations for managers. In this pilot study, we built an implementation framework for the inception of certification in healthcare facilities, particularly at nurse level activities. Our hypothesis comprised two objectives: the identification of key implementation process components, and the precise definition of these elements within local social activities.Methods: This study used a two-step abductive approach. The first was inductive, and consisted of a qualitative case study, where we analysed the implementation of certification procedures in a French teaching hospital. The study was conducted between April and December 2019. Data were collected using semi-structured interviews, and observations by shadowing. In the second step, the emerging data were analysed using two approaches: The Quality Implementation Tool (QIT) and Translational Mobilisation Theory (TMT). Results: Sixteen interviews were conducted with managers and nurses. We also accumulated 83 observational hours from two different wards. Our results showed that, first, all the retrieved elements over the implementation of certification procedures were captured by the QIT components and only one component was no applicable for the studied case. Second, we identified the elements in the local context of activity, with the different interrelationships between actors, actions and contexts, through the TMT. Third, our analyses were integrated and translated into a framework that described the implementation of certification procedures in healthcare facilities and with interest to the implementation at nurse/mid-managers level. In adopting QIT, the framework components took a transversal aspect then adapted to the local context of work through the TMT.Conclusions: In this study, we generated an implementation framework that underpinned a certification procedures implementation. Our approach revealed broad interactions between proximity managers, teams and contexts during change mobilisation, not captured by transversal framework only as QIT. Going forward, this framework must be tested in future empirical studies.
Exploring Intelligent Approach of Influence Minimization Considering the Node Surveillance in Online Social Networks
Authors: CHERIYAN JO , P Sajeev G
Published: November 2020

Attractive information such as innovations, awareness campaigns, branding, and advertising help people positively. Whereas, awful information such as rumors, malicious viruses, pornography, and revenge disturb people. The negative information contributes to chaos among people; therefore, it is to be blocked and hinder from further diffusion. This has motivated us towards the study of the problem named influence minimization. As the real world network can be modeled to a multilayer network, we focus our study towards the information diffusion through a multilayer network. Each node assigns a threshold, and its variation affects the rate of influence propagation across the network. In the influence minimization problem, the energy level of each node changes that help to formulate the function that minimizes the influence propagation. By applying two reduction policies, we are able to optimize our objective of minimizing the influence towards repulsive information. In this article, we consider the user response and its surveillance in the network. Repeated experiments on real networks has helped us to validate the proposed methods.
HIV/AIDS Stigma Reduction as a Risk Factor for New HIV Infections: A Lived Experience Study of HIV Positive Young Women in a Rural Setting of Northern Uganda
Authors: Kabunga Amir , Kenneth Maxson Anyolitho
Published: November 2020

BackgroundHIV/AIDS-related stigma is a global problem among HIV patients with far-reaching implications. However, stigma reduction among HIV positive young women may be a catalyst to new HIV infections. This study aimed at exploring the coping strategies used and influence of HIV-related stigma on new infections among HIV positive young women in a rural setting. MethodsA cross-sectional exploratory research design was used. HIV positive young women in the catchment area of Aboke Health Center IV were part of the study. In-depth interviews were used to collect data and analysis was done using thematic approach. ResultsThe results from the data showed that acceptance of counseling and social support are some of the ways HIV-positive young women coped up with stigma. The results also showed that While HIV-related reduction has influenced positively for some HIV positive young mothers, to others as HIV-related stigma reduces, young women living with HIV are likely to get involved in risky sexual activities like having unprotected sex thus increasing HIV transmission. ConclusionsHIV-related reduction has influenced positively for some HIV positive young mothers. However, to others as HIV-related stigma reduces, young women living with HIV are likely to get involved in risky sexual activities like having unprotected sex thus increasing HIV transmission. Based on the results, there is need to understand the negative effects HIV-related stigma reduction as this may have implications for further transmission and control of HIV pandemic. Also, further research is needed to understand whether lessening HIV-related stigma encourages risky sexual behaviors among young women.
WITHDRAWN: Novel lncRNA-HZ04 Promotes BPDE-Induced Human Trophoblast Cell Apoptosis and Miscarriage by Up-Regulating IP3R1/CaMKII/SGCB Pathway by Competitively Binding with miR-hz04
Authors: Huang Wenxin , Dai Mengyuan , Mi Chenyang , Liang Tingting , Qiu Taotao , Xu Zhongyan , Xie Jiayu , Chen Weina , Tian Peng , Zhang Shuming , Zhang Huidong
Published: November 2020

BackgroundMiscarriage seriously hinders human reproduction. BaP (benzo(a)pyrene) and its metabolite BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide) could cause trophoblast cell dysfunctions and might further induce human miscarriage. However, the underlying mechanisms remain largely unknown. ResultsHerein, we identified a novel lnc-HZ04 up-regulated and a novel miR-hz04 down-regulated in the unexplained recurrent miscarriage (RM) villous tissues relative to the healthy control tissues and also in the BPDE-exposed trophoblast cells. Lnc-HZ04 served as competing endogenous RNA (ceRNA), directly and specifically bound with miR-hz04 on its target site, and diminished the inhibition effects of miR-hz04 on IP3R1 mRNA expression level and its mRNA stability, thus activated Ca2+-mediated IP3R1/p-CaMKII/SGCB apoptosis pathway, which further promoted trophoblast cell apoptosis. The miR-hz04 target site, but not its mutant, on lnc-HZ04 played important roles in these regulations. In normal trophoblast, relatively less lnc-HZ04 and more miR-hz04 inhibited this apoptosis pathway and gave normal pregnancy. After exposure to BPDE or in the RM tissues, relatively more lnc-HZ04 and less miR-hz04 activated this apoptosis pathway and induced miscarriage. BaP could also induce mice miscarriage by up-regulating this corresponding murine apoptosis pathway. ConclusionsThis work discovered that lnc-HZ04 served as a ceRNA for miR-hz04 and up-regulated IP3R1/CaMKII/SGCB pathway, which promoted the BPDE-induced human trophoblast cell apoptosis and the occurrence of miscarriage, providing novel scientific and clinical understanding in the occurrence of unexplained miscarriage.
Data Mining and System Pharmacology to Elucidate the Efficiency and Mechanism of Chinese Medicine in Treating Primary Liver Cancer
Authors: Zhang Zhen , Zeng Puhua , Gao Wenhui , Tian Sha , Zhou Qing , Wang Yi , Zhu Wenhao , Tian Xuefei
Published: November 2020

BACKGROUNDPiling studies have demonstrated that Chinese medicine (CM) is effective in treating PLC. However, underlying mechanism of CM in treating PLC remains confused. MATERIAL AND METHODThe information of 524 patients with PLC were collected and separated to CM group and Less-CM group based on the time of taking CM. Then, the prescriptions in CM group were collected to identify the corn drugs. System Pharmacology was employed to explore the mechanism of corn drugs in treating PLC.RESULTSIn univariate and multivariate analysis, taking Chinese medicines more than 6 months was an independent prognostic factor. Then, Traditional Chinese Medicine Inheritance Support System was employed to find out the core drugs that really benefit for PLC patients. Totally, 153 ingredients from 9 core drugs (HXCF) were screened out. Fifty-five genes were identified for HXCF against PLC. The pathways were found as the mechanism of HXCF to treat PLC. Docking studies suggested amount of ingredients in HXCF exerts therapeutic effects against PLC, at least in part, by modulating the function of c-JUN and IL-6.CONCLUSIONOur results verified the effectiveness of CM in treating PLC and mined the corn drugs. What’s more, our result also predicted active components and potential targets of HXCF for the application to PLC from a holistic perspective, as well as provided valuable direction for further research of HXCF and improved comprehension of PLC.
Domestic violence, food insecurity and mental health of pregnant women in the COVID-19 lockdown in Cape Town, South Africa
Authors: Abrahams Zulfa , Boisits Sonet , Schneider Marguerite , Prince Martin , Lund Crick
Published: November 2020

Introduction Common mental disorders (CMD) such as depression and anxiety are associated with low household income, food insecurity and intimate partner violence in perinatal women. The national COVID-19 lockdown in South Africa resulted in increased levels of poverty and food insecurity. We aimed to explore the relationship between CMDs, food insecurity and experiences of violence among pregnant women during the COVID-19 lockdown.Methods Perinatal women, attending 14 healthcare facilities in Cape Town, were enrolled in the study during baseline data collection before the COVID-19 lockdown. During the lockdown period, fieldworkers telephonically contacted the perinatal women who were enrolled in the study and had provided contact details. The following data was collected from those who consented to the study: socio-demographic information, mental health assessment, food insecurity status and experiences of abuse. Poisson regression was used to model the associations of a number of risk factors with the occurrence of CMDs.Results Of the 2149 women enrolled in the ASSET study, 885 consented to the telephonic interviews. We found that 12.5% of women had probable CMDs and 43% were severely food insecure. Psychological distress increased significantly during the lockdown period, compared to before the COVID-19 outbreak. The strength of the association between key risk factors measured during the lockdown and psychological distress increased during the COVID-19 lockdown. Using multivariate Poisson regression modelling, we showed that the risk of CMDs was almost three times more likely in women who were severely food insecure or who experienced psychological or sexual abuse. Conclusions This study provides evidence of the effect of the COVID-19 lockdown on the mental health status of perinatal women living in low resource settings in Cape Town, and highlights how a crisis such as the COVID-19 lockdown amplifies the psycho-social risk factors associated with CMDs in perinatal women.
Caputo SIR Model for COVID-19 under Optimized Fractional Order
Authors: Alshomrani Ali S. , Ullah Malik Z. , Baleanu Dumitru
Published: November 2020

Everyone is talking about coronavirus from last couple of months due to its exponential spread throughout the globe. Lives have become paralyzed and as many as 180 countries are so far affected with 928,287 (14 September, 2020) deaths within couple of months. Ironically, 29,185,779 are still active cases. Having seen such drastic situation, a relatively simple epidemiological SIR model with Caputo derivative is suggested unlike more sophisticated models being proposed nowadays in the current literature. Major aim of the present research study is to look for possibilities and extents to which the SIR model fits the real data for the cases chosen from 01 April to 15 March, 2020, Pakistan. To further analyze qualitative behavior of the Caputo SIR model, uniqueness conditions under the Banach contraction principle are discussed and stability analysis with basic reproduction number is investigated using Ulam-Hyers and its generalized version. Best parameters have been obtained via nonlinear least-squares curve fitting technique. The infectious compartment of the Caputo SIR model fits the real data better than classical version of the SIR model [4]. Average absolute relative error under the Caputo operator is about 48% smaller than the one obtained in the classical case (ν = 1). Time series and 3D contour plots offer social distancing to be the most effective measure to control the epidemic.
Prevalence and correlates of adherence to the combined movement guidelines among Czech children and adolescents
Authors: Rubín Lukáš , Gába Aleš , Dygrýn Jan , Jakubec Lukáš , Materová Eliška , Vencálek Ondřej
Published: November 2020

Background: There are limited studies on the prevalence of adherence to the combined guidelines for physical activity (PA), sedentary behavior, and sleep in children and adolescents. Moreover, little is known about correlates of adherence to the guidelines. Therefore, the main aim of this study is to examine the prevalence and identify the correlates of adherence to the combined movement guidelines among children and adolescents. Methods: A total of 355 children aged 8–13 years (44% boys) and 324 adolescents aged 14–18 years (43% boys) from the Czech Republic participated in this study. PA and sleep duration were estimated using multi-day 24-hour raw data from wrist-worn accelerometers. Recreational screen time was parent proxy-reported in children and self-reported in adolescents. Seventeen potential correlates were grouped into three homogenous categories for biological and cognitive, behavioral, and family correlates. The multi-level multivariable logistic regression was applied to identify correlates of adherence to combined movement guidelines and to specific combinations of any of two recommendations.Results: Approximately 6.5% of children and 2.2% of adolescents met all recommendations of the combined movement guidelines. In children, girls (OR = 0.4; 95% CI = 0.1–0.9) and participants with overweight or obese fathers (OR = 0.3; 95% CI = 0.1–0.7) had significantly lower odds of adherence to the combined movement guidelines. Additionally, children had higher odds of meeting specific combinations of two recommendations if they reported regular fruit and vegetable intake, participated in organized PA, or if their fathers had a university degree. Meanwhile, paternal overweight and obesity, and high sleep efficiency were associated with lower odds of meeting specific combinations of recommendations. In adolescents, sex, fruit and vegetable intake, organized PA, and active play were correlates of meeting specific combinations of any two recommendations. Conclusions: A low proportion of children and adolescents met the combined movement guidelines and several correlates related to family were identified. Family is a key source of influence for healthy movement behaviors during childhood and adolescence.
Photoacoustic Imaging in Evaluating Early Intestinal Ischemia and Reperfusion Injury with Rat Models
Authors: Wang Rui , Pan Teng , Huang Lin , Liao Chengde , Li Qinqing , Jiang Huabei , Yang Jun
Published: November 2020

Purpose: It is still a challenge to distinguish whether the damaged intestine is viable or not in the treatment of acute mesenteric ischemia. In this study, photoacoustic imaging (PAI) was used to observe the activity of intestinal tissue after ischemia and reperfusion injury in rats.Methods: With the approval of animal ethics committee our university, in vivo study was carried out. Forty male SD rats were randomly divided into four groups: sham operated (SO) group, 1 h ischemia group, 2 h ischemia group and ischemia-reperfusion (I/R) group. In the ischemia group, superior mesenteric artery (SMA) was isolated and clamped for 1 h (n = 10) and 2 h (n = 10), respectively. In I/R group, after ischemia for 1 hour, the clamp was removed and reperfused for 1 hour (n = 10). The same time interval of SMA was taken as SO group (n = 10). Immediately after the establishment of the animal model, PAI examination was performed. After PAI examination, the small intestine was collected for histopathology.Results: The PAI derived parameters of 2 h ischemia group were significantly different from those of SO group and I/R group (P < 0.05). The levels of Hb, HbR, map760 and map 840 were increased in different degrees in ischemia group, especially in 2 h ischemia group (compared with SO group, P < 0.01). With the prolongation of ischemia time, the injury was aggravated. In immunohistochemistry, compared with SO group, BAX increased significantly in 2 h ischemia group (P < 0.01). Similarly, Caspase-3 was significantly higher than the baseline level (P < 0.05). The level of HIF-1a increased in 2 h ischemia group and I/R group (P < 0.05). TUNEL staining showed that the number of apoptotic positive nuclei in 2 h ischemia group was significantly higher than that in SO group (P < 0.05). HE staining showed that ischemia for 2 hours was the most serious, with obvious mucosal damage, extensive epithelial injury and bleeding.Conclusions: PAI can be used as an effective tool to detect acute intestinal ischemia injury and quantitatively evaluate tissue viability.
Clinical Outcomes of Unicompartmental Knee Arthroplasty in Patients with Full- Versus Partial-Thickness Cartilage Loss: A Systematic Review and Meta-Analysis
Authors: Ma Jinhui , Yan Yan , Wang Weiguo , Wang Bailiang , Yue Debo , Guo Wanshou
Published: November 2020

Bakground This meta-analysis was designed to compare postoperative patient-reported outcomes and reoperation rates following unicompartmental knee arthroplasty (UKA) between patients with full-thickness cartilage loss (FTCL) and partial-thickness cartilage loss (PTCL).Methods Multiple databases, including PubMed, Embase, Cochrane Library, and CNKI, were searched to identify studies comparing the Oxford Knee Score (OKS), American Knee Society (AKS) score, and reoperation rates between patients with FTCL and PTCL following UKA. Mean differences were calculated for continuous outcomes, and odds ratios were calculated for binary outcomes.Results A total of 613 UKAs (233 PTCL and 380 FTCL) from five retrospective cohort studies were included. Three studies compared OKSs after ≥2 years of follow-up. The mean difference in postoperative OKSs was significantly higher by 2.92 in the FTCL patients than in the PTCL patients (95% confidence interval [CI] −5.29 to −0.55; P = 0.02). The improvement in the OKS was significantly higher by 2.69 in the FTCL patients than in the PTCL patients (95 % CI −4.79 to −0.60; P = 0.01). AKS-knee and AKS-function scores were assessed in two studies at a mean follow-up time of >3.9 years. The mean difference in AKS-knee scores was similar between the groups (95%CI −9.14 to −3.34; P = 0.36), whereas the pooled mean difference in AKS-function scores was 5.63 higher in the FTCL group (95%CI −9.27 to −1.98; P = 0.002). All studies presented data on reoperation rates and showed that they were statistically higher in patients who underwent UKA with PTCL (OR 2.24, 95%CI 1.15–4.38, P = 0.02).Conclusions Compared with PTCL, FTCL achieved superior postoperative patient-reported outcomes and lower reoperation rates following UKA.
Grazing Effects on Day Butterflies in a Mediterranean Woodland Ecosystem in Northern Israel
Authors: Am Gad Ish , Oron Talia
Published: November 2020

The effects of cattle grazing on biodiversity in Mediterranean woodlands are yet unknown. To assess these effects on diurnal butterflies, we conducted daytime surveys in the Mt. Meron nature reserve (northern Israel) in two habitats over two different years. In each habitat we chose one site that was grazed by cattle and, as a control, a similar but ungrazed site. Belt transects (5m wide), divided for 100m replications, were surveyed five times on ridges in 2015 (11 replications, 538 butterflies, 25 species), and nine times in valleys in 2016 (12 replications, 3,944 butterflies, 38 species). In both habitats, species similarity index between sites was high. Richness was higher in the ridge control and evenness was higher in the valley grazed site. In both habitats total abundance was ca. twofold higher in the control, and the abundance of woody affiliated butterflies was threefold higher in the control, probably due to overgrazing, which affects butterflies’ breeding niches. For batha polyphagous and oligophagous butterfly species, abundance was similar between the sites, and for a few of those, associated with increaser plants, it was even higher in the grazed sites. However, the batha monophagous species were significantly more abundant in the control. Monophagous and endangered species were found to be more sensitive to cattle grazing. We conclude that the current cattle grazing management in Mt. Meron reserve affects butterfly populations negatively. Therefore, we recommend more regulated grazing and early-season deferment precautions, along with designation of no-grazing areas in reserves.
Three-Phase Borate Solid Solution With Low Sintering Temperature, High Quality Factor, and Low Dielectric Constant: Experimental and DFT Study
Authors: Peng Rui , Su Hua , Li Yuanxun , Lu Yongcheng , Shi Liang , Du Wei , Tang Xiaoli , Yu Guoliang , Chen Minshu
Published: November 2020

The sintering and microwave dielectric properties of a ceramic material based on Mg2+ substituted Zn3B2O6 have been widely studied using first principles calculations and experimental solid-state reactions. Characterization methods include the Network Analyzer, X-ray, Raman diffraction, scanning electron microscopy, energy-dispersive spectroscopy, and differential-thermal & thermo-mechanical analyzer. The increasing amount of Mg2+ results in the appearance of Mg2B2O5 and ZnO, and the mutual substitution (Mg2+ and Zn2+) phenomenon has emerged in Zn3B2O6 and Mg2B2O5. The mechanisms have been explained with the help of DFT calculations. The bond parameters and electron distributions of the ZnO4 tetrahedron and the MgO6 octahedron have been modified due to substitution. The sintering, substitution, and phase formation properties have been analyzed quantitatively through the energy parameters. The best dielectric properties were obtained for x=0.20 sintered at 950℃, εr=6.47, Q×f=89,600GHz (15.2GHz), τf=-48.6ppm/℃, relative density=96.7%. The substitution of Mg2+ to Zn2+ is a feasible method to improve the microwave dielectric properties of the Zn3B2O6 ceramic.
Što ustvari ispituje Test očiju? Neke metodološke teškoće ispitivanja teorije uma Testom očiju
Authors:   Dom za djecu “Maestral”, Split, Barać Bruno , Vulić-Prtorić Anita ,   Odjel za psihologiju, Sveučilište u Zadru, Zadar
Published: November 2020

Test čitanja misli iz očiju (Reading the Mind in Eyes Test – RMET, Baron-Cohen, Wheelwright, Hill, Raste i Plumb, 2001) ili kraće Test očiju jedan je od najčešće korištenih mjernih instrumenata za procjenu teorije uma u odraslih i to kako u istraživanjima, tako i u kliničkoj praksi. No, koliko god bio popularan, rijetki su radovi u kojima se navode psihometrijski pokazatelji za taj test. Stoga su u ovom radu postavljena dva glavna cilja: provesti analizu podataka iz dosadašnjih istraživanja u kojima se navode psihometrijski pokazatelji ovog testa, i usporediti ih s psihometrijskim karakteristikama dobivenim u uzorku ispitanika u našoj populaciji. U istraživanju je sudjelovalo 97 ispitanica, studentica psihologije u Zadru. Osim Testa očiju korišten je Zadatak kratke priče (SST), kojim se ispituje kognitivna teorija uma, te Upitnik empatije (EPQ–IVE/A) i Torontska skala aleksitimije (TAS–20). Podaci iz dosadašnjih istraživanja upozoravaju na brojne teškoće u konceptualizaciji Testa očiju, a analiza rezultata ispitivanja u našem uzorku nije doprinijela boljem razumijevanju predmeta mjerenja ovog testa. Osim niske pouzdanosti i upitne faktorske strukture, utvrđeno je da ne postoji povezanost s mjerama empatije i aleksitimije, te drugog aspekta teorije uma mjerenog Zadatkom kratke priče (SST). S obzirom na to da je do danas Test očiju zauzeo važno mjesto u procjeni interpersonalnog funkcioniranja, te sposobnosti prepoznavanja emocija i procesiranja socijalnih informacija u kliničkim uzorcima, predlažu se postupci za moguća poboljšanja ovog mjernog instrumenta. Ključne riječi: Test očiju, teorija uma, empatija, aleksitimija
Povezanost kvalitete života i načina suočavanja sa stresom kod medicinskih sestara
Authors:   Osnovna škola Ive Andrića, Zagreb, Arapović Mirna , Despot Lučanin Jasminka ,   Fakultet hrvatskih studija, Sveučilište u Zagrebu, Zagreb
Published: November 2020

Ciljevi ovog istraživanja bili su ispitati kvalitetu života, stresnost posla i načine suočavanja sa stresom kod medicinskih sestara zaposlenih u bolnici te utvrditi doprinose li neke sociodemografske karakteristike, samoprocjena stresnosti posla i strategije suočavanja sa stresom predviđanju kvalitete u različitim domenama života medicinskih sestara. Ispitane su 133 medicinske sestre (88% žena) u dobi od 20 do 63 godine, zaposlene u Kliničkom bolničkom centru Zagreb. Primijenjeni su upitnici: općih podataka i samoprocjene stresnosti posla, skraćena verzija COPE upitnika suočavanja sa stresnim situacijama te skraćena verzija upitnika kvalitete života WHOQOL-BREF, koji obuhvaća četiri domene: tjelesno zdravlje, psihičko stanje, društvenu interakciju i okoliš. Rezultati su pokazali da je kvaliteta života medicinskih sestara dobra u svim domenama, a razina stresnosti posla je jako visoka. Ispitane medicinske sestre najčešće koriste strategije suočavanja usmjerene na problem, a najrjeđe izbjegavajuće strategije. Niža razina samoprocjene stresnosti posla i viši stupanj obrazovanja značajni su prediktori bolje kvalitete života u domenama tjelesnog zdravlja i psihičkog stanja. Viša razina stresnosti posla jedini je značajni prediktor lošije kvalitete života u domeni okoliša. Učestalije izbjegavajuće suočavanje jedini je značajni prediktor lošije kvalitete života u domeni društvenih odnosa. Rezultati istraživanja mogu biti korisni u planiranju intervencija i edukacija za poboljšanje suočavanja sa stresom medicinskih sestara. Ključne riječi: kvaliteta života, medicinske sestre, stres na radnom mjestu, suočavanje sa stresom
Važnost slike tijela kao moderator odnosa između zadovoljstva slikom tijela i korištenja strategija za smanjenje težine
Authors:   Filozofski fakultet, Sveučilište u Rijeci, Rijeka, Kukić Miljana
Published: November 2020

Cilj ovoga istraživanja bio je ispitati spolne razlike u slici tijela i uporabi strategija za smanjenje težine te ispitati mogući moderatorski učinak važnosti slike tijela na odnos između nezadovoljstva slikom tijela i korištenja strategija za smanjenje težine u adolescenata. U istraživanju je sudjelovalo ukupno 913 srednjoškolaca (65,7% djevojaka, prosječna dob 16,2 ± 1,18 godina). Primijenjen je Inventar slike tijela i strategija za promjenu tjelesnog izgleda. Rezultati su pokazali da su djevojke, općenito, nezadovoljnije svojom slikom tijela, pridaju joj veću važnost te češće koriste strategije za smanjenje težine nego mladići. Rezultati regresijskih analiza pokazali su da važnost slike tijela ima moderatorski učinak na odnos između nezadovoljstva slikom tijela i korištenja strategija za smanjenje težine. Mladići i djevojke koji su nezadovoljni svojom tjelesnom težinom, a ujedno joj pridaju visoku važnost, češće koriste strategije za smanjenje težine nego mladići i djevojke koji su nezadovoljni tjelesnom težinom, ali joj ne pridaju visoku važnost. Isti je obrazac prisutan u međuodnosu važnosti izgleda pojedinih dijelova tijela, nezadovoljstva izgledom pojedinih dijelova tijela i korištenja strategija za smanjenje težine. Ovo istraživanje pruža dodatni uvid u ulogu važnosti slike tijela u adolescenata. Rezultati ovoga istraživanja mogu se koristiti kao smjernice za osmišljavanje preventivnih programa usmjerenih na nezadovoljstvo slikom tijela i njegove posljedice. Ključne riječi: nezadovoljstvo slikom tijela, važnost slike tijela, strategije za smanjenje težine, adolescencija
Stavovi prema gluhim i nagluhim učenicima
Authors:   Zdravstveno učilište Zagreb, Zagreb, Kozjak Mikić Zlatka , Merlin Ivana ,   Škola za medicinske sestre Vinogradska, Zagreb, Mikić Karla ,   Fakultet hrvatskih studija, Sveučilište u Zagrebu, Zagreb
Published: November 2020

Pored stereotipa o gluhima, kao glavni razlozi krivih medicinskih dijagnoza ove skupine pacijenata identificiraju se nerazumijevanje kulturološkog aspekta gluhoće i nepoznavanje adekvatnog načina komuniciranja s njima (Ubido, Huntington i Warburton, 2002). Za komunikaciju i stavove prema gluhima značajna je kvaliteta prethodnog kontakta s gluhim pojedincima (De Laat, Freriksen i Vervloed, 2013), stoga bi pozitivno iskustvo i pozitivan stav učenika koji se školuju za zanimanja u zdravstvu mogli pridonijeti boljem razumijevanju i kvalitetnijoj komunikaciji s gluhim pacijentima u njihovu budućem radu. Svrha istraživanja bila je prikupiti podatke o stavovima učenika zdravstvenih škola prema gluhim i nagluhim vršnjacima te njihovoj integraciji u redovne škole, za što je korišten adaptirani Inventar inkluzije gluhih i nagluhih učenika (Hung, 2005). Prikupljeni su podatci o percipiranoj bliskosti s gluhim i nagluhim učenicima, učestalosti prethodnih dobrovoljnih kontakata s gluhim i nagluhim osobama, percepciji razrednog ozračja povezanog s integracijom gluhih učenika u redovne škole te o tome integriraju li škole gluhe/nagluhe učenike ili ne. U istraživanju je sudjelovalo 328 srednjoškolaca u dobi od 15,5 do 16,5 godina, među kojima je bilo 270 djevojaka i 58 dječaka, iz različitih zdravstvenih programa. Percipirana bliskost s gluhim i nagluhim učenicima relativno je visoka, odnosno stavovi su pozitivni. Djevojke su iskazale višu percipiranu bliskost u odnosu na dječake, ali je razlika, iako statistički značajna, vrlo mala. Nisu dobivene razlike u percipiranoj bliskosti ovisno o tome imaju li škole integrirane gluhe učenike ili ne. Učestalost prethodnog dobrovoljnog kontakta s gluhim/nagluhim vršnjacima unutar razreda povezana je s percepcijom bliskosti s njima. Učenici koji imaju pozitivniju percepciju razrednog ozračja s obzirom na posljedice integracije gluhih vršnjaka na osobni i socijalni život unutar razreda te na razredne aktivnosti iskazali su veću percipiranu bliskost s gluhim učenicima, iako su i te razlike vrlo male. Ključne riječi: učenici zdravstvenih škola, gluhi i nagluhi učenici, zdravstveni djelatnici
Group-Based Direct and Indirect Approaches to Language Therapy for Children With Developmental Language Disorder: a Pre-Experimental Study
Authors:   Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, Matić Ana , Kuvač Kraljević Jelena ,   Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb, Kologranić Belić Lana ,   Polyclinic for the Rehabilitation of Listening and Speech SUVAG, Zagreb, Olujić Tomazin Marina ,   Faculty of Education and Rehabilitation Sciences, University of Zagreb, Zagreb
Published: November 2020

Developmental Language Disorder (DLD) is among the most frequent communication disorders in early childhood. It affects the quality of the child’s academic and social life. Speech-language therapy to counter this impairment is usually individual and based on a direct approach with the therapist. New approaches begin to emerge, involving group settings, as well as indirect involvement of a parent who is constantly monitored and supervised by the therapist. Group and indirect therapies are infrequently used in Croatia, even though their effectiveness is well demonstrated worldwide. The aims of the current study were: 1) to examine whether two approaches to language therapy: group-based direct and indirect at home, can foster early literacy in children with DLD, and 2) to gain insight into parental perception of group therapy and how they perceived its potential influence on their children’s lives. It has a pre-experimental design and thus presents the first step towards an evidence-based effectiveness study. Eight children and their parents participated in the programme. Children’s language progress was measured using language tests before and after the programme, and parents’ perception of the therapy was evaluated using a post-programme questionnaire. The results suggest that group-based direct and indirect approaches can foster early literacy in preschool children with DLD. Parental perception of the therapy was positive; they expressed strong trust in the therapy and reported finding it useful for their children. The outcomes of the present pre-experimental study further corroborate positive effects of carefully planned therapies and serve as a step forward in conducting effectiveness studies in order to establish evidence-based practices in Croatia. Keywords: developmental language disorder, pre-experimental study, group language therapy, direct and indirect approaches, early literacy
Mjerenje depresivnosti u postupku procjene radne sposobnosti: Psihometrijska obilježja skale depresije D-92
Authors:   Zavod za vještačenje, profesionalnu rehabilitaciju i zapošljavanje osoba s invaliditetom, Osijek, Hajncl Ljerka , Kolesarić Vladimir ,   Filozofski fakultet, Sveučilište u Zagrebu, Zagreb, Vučenović Dario ,   Fakultet hrvatskih studija, Sveučilište u Zagrebu, Zagreb
Published: November 2020

Skala depresije D-92 (Krizmanić i Kolesarić, 1994) izvorni je hrvatski psihologijski instrument za mjerenje intenziteta simptoma depresivnosti u kliničkoj populaciji odraslih. Oslanjajući se na Beckovu teoriju nastanka i održavanja simptoma depresije, u skalu su uključene čestice kojim se ispituje odnos ispitanika prema sebi, prema drugim ljudima i prema budućnosti. U ovom radu provjerena je osjetljivost, pouzdanost, konvergentna i divergentna valjanost te sposobnost D-92 skale da diferencira ispitanike unutar klinički dijagnosticiranih skupina s depresivnim poremećajem, anksioznim poremećajima i drugim duševnim poremećajima. Ispitivanje je provedeno na prigodnom uzorku od 210 klinički dijagnosticiranih ispitanika s depresivnim, anksioznim poremećajem i drugim duševnim poremećajima pri procjeni radne sposobnosti. Ispitanici su popunjavali test kognitivnih sposobnosti, Crown-Crispov indeks iskustava i skalu depresije D-92. Rezultati istraživanja upućuju na vrlo dobru osjetljivost skale da razlikuje osobe prema broju i intenzitetu simptoma depresije u odabranom kliničkom uzorku u situaciji procjene radne sposobnosti (SD = 9,70). Unutrašnja konzistencija (α = 0,89) upućuje na zadovoljavajuću pouzdanost skale D-92. Konvergentna valjanost skale podržana je visokom korelacijom sa subskalom depresivnosti u CCII upitniku (r = 0,62). U korist divergentnoj valjanosti ne ide visoka korelacija s mjerama generalizirane anksioznosti (r = 0,62) i somatizirane anksioznosti (r = 0,55) na CCII upitniku. Univarijatna analiza varijance razlika u obilježju depresivnosti između skupina s različitim bolestima upućuje na to da je intersekcija raspodjele rezultata visoka pa ispitanici mogu pripadati u sve skupine bolesti. Ključne riječi: procjena radne sposobnosti, skala depresije D-92, psihometrijske karakteristike
Engineered swift equilibration of brownian particles: consequences of hydrodynamic coupling
Authors: Salambô DAGO , Besga Benjamin , Mothe Raphaël , Guéry-Odelin David , Trizac Emmanuel , Petrosyan Artyom , Bellon Ludovic , Ciliberto Sergio
Published: November 2020

We present a detailed theoretical and experimental analysis of
Engineered Swift Equilibration (ESE) protocols applied to two
hydrodynamically coupled colloids in optical traps. The second particle
disturbs slightly (10\%10%
at most) the response to an ESE compression applied to a single
particle. This effect is quantitatively explained by a model of
hydrodynamic coupling. Then we design a coupled ESE protocol for the two
particles, allowing the perfect control of one target particle while the
second is enslaved to the first. The calibration errors and the
limitations of the model are finally discussed in detail.
MULTIPLE LINEAR REGRESSION APPROACH FOR SHORT-TERM FORECASTING OF ELECTRIC ENERGY CONSUMPTION IN TOGO
Authors:   ResearchLaboratory in Engineering Sciences (Larsi), Regional Center of Excellence for the Control of Electricity (CERME), Department of Electrical Engineering of the National Superior School of Engineers (ENSI), University of Lome (UL), BP 1515, Lome, Togo., Adjamagbo Comlanvi , Adekunle Salami Akim ,   ResearchLaboratory in Engineering Sciences (Larsi), Regional Center of Excellence for the Control of Electricity (CERME), Department of Electrical Engineering of the National Superior School of Engineers (ENSI), University of Lome (UL), BP 1515, Lome, Togo., Bokovi Yao ,   ResearchLaboratory in Engineering Sciences (Larsi), Regional Center of Excellence for the Control of Electricity (CERME), Department of Electrical Engineering of the National Superior School of Engineers (ENSI), University of Lome (UL), BP 1515, Lome, Togo., Gado Djamil ,   ResearchLaboratory in Engineering Sciences (Larsi), Regional Center of Excellence for the Control of Electricity (CERME), Department of Electrical Engineering of the National Superior School of Engineers (ENSI), University of Lome (UL), BP 1515, Lome, Togo., Senah Akoda Ajavon Ayite ,   ResearchLaboratory in Engineering Sciences (Larsi), Regional Center of Excellence for the Control of Electricity (CERME), Department of Electrical Engineering of the National Superior School of Engineers (ENSI), University of Lome (UL), BP 1515, Lome, Togo.
Published: November 2020

A Linear Multiple Regression approach is used to model the energy consumption of electricity in Togo. This model is developed from the load data recorded at the electric power source stations in Togo during the period from 2016 to 2017. This model predicts four input parameters (Day of the week, the type of day (working day). or not), Hours in the day and Load data of the same time of the previous day) is used to predict the electrical energy consumption data for the period of 2018 with a MAPE of 4.4964% and a correlation coefficient R2 equal to 95.5889%.
Pulmonary Sling: verification of prenatal diagnosis after 5 years
Authors: S.I. Buryakova , M.V. Medvedev , V.V. Shipulin
Published: November 2020

Results of postnatal verification of the case of prenatal diagnosis of the left pulmonary artery sling and
literature review are presented.
Symptomatic Slow-Acting Drugs (SYSADOA) is the new reality in the treatment of osteoarthritis
Authors:   RM Analytics, Prozherina Yuliya
Published: November 2020

Osteoarthritis (OA) is the most common chronic progressive joint disease. Over the last years, it has been evidenced that OA is associated with an increased risk of death, which may be explained by low-intensity chronic inflammation underlying its pathogenesis, long-term pain syndrome, and high comorbidity. Considering the above, the FDA classified OA as a serious disease that requires more careful monitoring of patients and the earliest possible prescription of effective therapy in August 2018 [1].
Comparison and analysis of the fda approved orphane drugs registerand the vital and essential drugs list of the Russian Federation
Authors:   Saint, Petersburg Chemical Pharmaceutical University, Russia, St Petersburg, Yurochkin D.S. , Leshkevich A.A. ,   Saint, Petersburg Chemical Pharmaceutical University, Russia, St Petersburg, Golant Z.M. ,   Saint, Petersburg Chemical Pharmaceutical University, Russia, St Petersburg, NarkevichSaint I.A. ,   Saint, Petersburg Chemical Pharmaceutical University, Russia, St Petersburg
Published: November 2020

The article presents the results of a comparison of the Orphan Drugs Register approved for use in the United States and the 2020 Vital and Essential Drugs List approved on October 12, 2019 by Order of the Government of the Russian Federation No. 2406-r. The comparison identified 305 international non-proprietary names relating to the main and/or auxiliary therapy for rare diseases. The analysis of the market of drugs included in the Vital and Essential Drugs List, which can be used to treat rare (orphan) diseases in Russia was conducted.
Bronchial asthma: fundamental changes in the new GINA guidelines (2019)
Authors:   Remedium, Vodovozov Aleksey
Published: November 2020

The new guidelines of the Global Initiative for Asthma (GINA) has inspired a heated discussion among experts. The next version was published in 2018, but its revision appeared as early as in 2019. This is primarily due to the revision of the attitude towards short-acting beta-2-agonists, however, the approaches have changed significantly at other stages of bronchial asthma treatment as well, especially at the early stages. The emphasis has been placed on low-dose inhaled corticosteroids, as they have accumulated an evidence base at an adequate quality level. In fact, the 2019 GINA proposals are reduced to discontinuation of the common clinical practice and switching to fundamentally different approaches to the management of bronchial asthma, especially its mild form.
Review of pharmacy sales of plasters and self-adhesive dressings
Authors:   DSM Group, Nechaeva Yuliya
Published: November 2020

Review of pharmacy sales of plasters and self-adhesive dressingsYuliya Nechaeva, DSM Group Plasters are essential items for any medicine cabinet at home. The plasters are currently used not only in the treatment of wounds and attachment of bandages or catheters, but also have a therapeutic (for example, analgesic, venotonic, anti-edema action, etc.) or cosmetic effect (anti-cellulite, anti-wrinkle, anti-under-eye circles effects, etc.). In addition, the transdermal route of drug administration is gaining popularity.
Investment activity of pharmaceutical enterprises: 2019
Authors:   Remedium, Romanova Svetlana
Published: November 2020

The investment activities of pharmaceutical enterprises were analysed using the data from the state statistical reporting form No. P-2 “Information on investments to non-financial assets” (quarterly).
INSTITUIÇÃO DE UM PROTOCOLO DE VIGILÂNCIA ALIMENTAR E NUTRICIONAL NO MUNICÍPIO DE JAGUARI-RS
Authors: Taschetto Hailê Zeul Panisson , Medeiros Teles , Costenaro Regina Gema Santini , Haeffner Léris Salete , Benedetti Franceliane Jobim
Published: November 2020

Os controles periódicos antropométricos do Programa Bolsa Família (PBF) devem seguir os passos preconizados pelo protocolo do Sistema de Vigilância Alimentar e Nutricional (SISVAN). Mas, observou-se que este protocolo não estava sendo aplicado em sua plenitude no município de Jaguari-RS, perdendo-se a oportunidade de identificar as crianças com distúrbios nutricionais e tomar as medidas pertinentes a cada caso.  Com o objetivo de implementar um protocolo de Vigilância Alimentar e Nutricional (VAN) que seja efetivamente aplicado, foi desenvolvida uma pesquisa-ação. Após feito o diagnóstico do funcionamento/operacionalidade do SISVAN e conhecida a situação nutricional das crianças beneficiárias do PBF, público-alvo, foram implementadas alterações operacionais nas avaliações antropométricas semestrais e realizada capacitação antropométrica dos profissionais de saúde. A monitorização inicial, realizada durante um período de controle antropométrico do PBF, revelou resultados positivos na implementação do protocolo de VAN.

Regular nutritional assessment is one condicionality of  the Bolsa Familia Program (BFP) that must follow all recommended steps of Brazilian Food and Nutrition Surveillance System (SISVAN) protocol. However, it was observed that protocol was not accomplished in all extension in the city of Jaguari- RS, south of Brazil. That way, it was leaving out the opportunity for identifying children nutritional disorders and act in order to take adequate measures. An action research was performed in order to effectively implement a food and nutrition surveillance protocol (FNSP). First, it was verified the way SISVAN was been operated and it was also checked nutritional status from children enrolled in BFP. Then, operating changings were set up in anthropometric assessments and it was realized a training in anthropometry for health professionals.  Monitoring performed during an anthropometric assessment showed positive results in the process of FNSP implementation.