bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation and evaluation of ciprofloxacin solid dispersion tablets developed from stearic acid, Polyethylene Glycol 4000 and Soluplus
Authors: Agubata Chukwuma Obumneme , Ogbonna Eugenia Chinyere , Onyechi Jacob Okwuchukwu , Ugwu Calister Elochukwu , Obasi Josephat , Akudu Adaobi Ukamaka , Chidebelu Innocencia , Ani Njideka Ifeoma
Published: April 2023

Ciprofloxacin is a fluoroquinolone antibiotic with a broad spectrum of activity used for the treatment of various bacterial infections and is characterized by poor aqueous solubility and low permeability. The aim of this study is to formulate and characterize ciprofloxacin solid dispersions using hydrophilic and lipophilic matrices for improved product qualities and drug delivery. Ciprofloxacin hydrochloride tablets were formulated as solid dispersions by melting and solvent evaporation in tablet moulds using varying concentrations of stearic acid (10-40 %w/w), Polyethylene glycol 4000 (PEG 4000) (10-40 %w/w) and Soluplus® (10-20 %w/w as ethanolic solution) as components. The prepared tablets were evaluated for weight uniformity, friability, hardness, Fourier transform-infrared spectroscopy (FT-IR), moisture uptake, swelling index, disintegration time and dissolution rate, using standard methods and optimization techniques. The results showed uniform solid dispersion weights with friability, hardness, moisture uptake and swelling index of 0.4-0.5%, 3.0-7.5 kgf, mostly <20% and 1-71%, respectively. The formulations were chemically stable with no transformational interactions between components. Formulations without stearic acid disintegrated within 30 min whereas those containing the lipid broke up after more than 1 h. Drug release studies showed high immediate release in tablets without stearic acid but with cumulative steady state release higher in formulations with 10 %w/w Soluplus and different concentrations of stearic acid and PEG 4000. In conclusion, ciprofloxacin was presented as solid dispersion tablets with modified physicochemical attributes for improved drug delivery.

Keywords: Ciprofloxacin; solid dispersion; drug delivery
West Syndrome – Infantile Spasms: A Rare Paediatric Case Report
Authors: Murugan Akila , Umapathy P , Panchagiri Sabitha
Published: April 2023

West syndrome (WS) is a rare, severe form of epilepsy with onset in infancy and early childhood. It involves clustered epileptic spasm episodes, the aberrant interictal electroencephalogram pattern known as hypsarrhythmia, and neuropsychomotor delay. In this view, we present a case of a 6-year-old female child a known case of west syndrome, global developmental delay, hypothyroidism, and post-operative laparoscopic gastrotomy performed under general anaesthesia on March 31/2022, in view of recurrent aspiration and came with the chief complaints of seizure 6-7 episodes per day, decreased urine output, constipation for two days, straining to pass urine, and three episodes of vomiting. The history included that the baby cried immediately after birth, seizure on day 5 of life, and was shifted to the Neonatal intensive care unit (NICU), admitted there for 5 days because of respiratory distress syndrome and hyperalbuminemia. During their stay in the hospital, the child has been prescribed Lamotrigine 50mg, Levocarnitine 500mg, Levetiracetam 250mg, Clobazam 5mg, Phenobarbital 60mg, Sodium Valproate 100mg, Thyronorm 50mcg. Now the patient is symptomatically better. This case report intends to sensitize physicians in this region toward this rare neurological syndrome.

Keywords: Hypsarrhythmia, Infantile, Seizure, West syndrome.
NF-ĸB expression in endometriosis induced rat uterine tissue
Authors: ERMİŞ Işılay Sezen , DEVECİ Engin , Aşır Fırat
Published: April 2023

Objective: Our aim in this study is to examine the effects of endometriosis on uterine tissue.

Materials and methods: Two groups were formed, with eight rats in each group. Sham group was subjected only saline solution for 7 days. The endometriosis (EM) model was induced with estradiol benzoate (EB). In the EM group, EB was given to rats for 7 days. At the end of the experiment, blood was taken from the animals and serum total antioxidant status (TAS) and total oxidant status (TOS) values were studied. Uterine tissues were fixed in formalin and embedded in paraffin blocks. NF-ĸB 3 immune staining were performed on uterine sections. The results were examined under the microscope.

Results: Compared to sham group, TAS values were significantly decreased and TOS values were significantly increased in serum of rats belonging to EM group. In the analysis of NF-ĸB expression in uterine tissue of sham group, the expression was slight and found only in connective tissue cells and inflammatory cells. NF-ĸB expression was mainly negative. After EM induction, NF-ĸB expression was increased in degenerated epithelial cells and gland cells, inflammatory cells around the glands and blood vessel endothelial cells and lamina propria.

Conclusion: We think that NF-κB signal may be a determinant in the treatment of endometriosis.

Keywords: endometriosis, immunohistochemistry, NF-κB, biochemistry, rat
The Political and Economic Status of the Chinese Diaspora in Southeast Asia
Authors: Wang Yonghao
Published: April 2023

The relevance of the study stems from the Chinese government’s focus on developing cultural, economic partnerships with Asia-Pacific states. It is the Huaqiao who have contributed to this process, for example, there are many investors who balance the flow of money between China and other countries, as well as scholars who share scientific knowledge with Chinese citizens.

Aim. Based on the above, the aim of the study is to analyse the current position of the Chinese diaspora in the economic and political spheres of life in Southeast Asia.

Tasks. In order to successfully realise the objective, it is necessary to solve the research tasks:

to describe the essence of the concept of “diaspora” in the academic literature, as well as its specific features;

to consider the role of huaqiao in the formation of China’s external image;

to evaluate the degree of Chinese business activity in trade of the countries under consideration;4) to study the degree of Chinese diasporas’ participation in political life of the states of residence.

Methods. Analysis and synthesis of literary sources (while studying the concept of “diaspora”), historical method (while describing three main waves of Chinese diaspora migration and studying Chinese settlement in different parts of South-East Asia), descriptive method (while studying the place of Chinese diaspora in political and economic life of South-East Asia) were used as main research methods.

Results. The research results have been summarised according to the level of representation of the positive image of the Chinese as a result of the Huaqiao’s economic and political actions.

Conclusions. Firstly, about 75% of overseas Chinese, or 28 million people, live in modern Southeast Asian countries.

Secondly, within the framework of the business activities of the Chinese diaspora, the most significant factor of influence is the association of Chinese enterprises in the “bamboo network” and expansion of areas of cooperation with each other.

Third, the Chinese diaspora has different rights these days depending on the form of government and state structure of the country.
Impact of a pharmacist’s presence on medication usage in Long-Term Care Facilities: a retrospective cohort study
Authors: Gonçalves João , Requeijo Mariana , Sleath Betsy , Cavaco Afonso
Published: April 2023

Aim. To investigate the impact of pharmacists’ presence in long-term
care facilities (LTCFs) on medication usage. Methods. The study followed
a retrospective cohort design, with a sample of patients aged ≥ 65 years
old admitted to 3 LTCFs over 30 months. Data on age, gender, type of
stay, presence/absence of pharmacist and medication at admission and
discharge were obtained for study patients. Variations in the number of
medicines (NoM), anticholinergic burden (ACB), and potentially
inappropriate medication (PIMs), at admission and discharge, were
assessed as outcome variables. Anticholinergic burden and PIMs were
identified using the Anticholinergic Cognitive Burden scale and the
EU(7)-PIM List, respectively. One-sample t-tests were applied to compare
outcome variables’ mean values at admission and discharge. A 4-way ANOVA
was employed to test the association between background and outcome
variables. Partial Eta squared (η2) was used to measure the effect size.
Results. The 3 LTCFs assisted 1643 patients during the study period, of
which 1366 were included in data analysis. Only one LTCF had pharmacy
services. All outcome variables showed a statistically significant
increase at discharge compared with admission. Pharmacist’s presence was
statistically significant at improving the NoM (p<0.001) and
ACB score (p<0.001), while no statistically significant value
was reached on PIMs (p = 0.642). Small effect size values were reached
for pharmacist impact on the NoM and ACB score (η2 = 0.021, η2 = 0.011,
respectively). Conclusion. The present findings suggest that
pharmacists’ presence positively impacts the use of medications
implicated in adverse health outcomes in LTC patients.
Challenges of Lean Healthcare Implementation in Private Jordanian Hospitals
Authors: H Romany Thabet , Baqleh Lubna A.
Published: April 2023

Application of lean management in hospitals has a great impact in
reducing waste and waits with continuous improvement of healthcare. The
current study aimed at identification of the challenges and reality of
applying the lean management philosophy in private hospitals in Jordan.
Many challenges have been identified such as management roles and
responsibilities, people construction, resources management, strategy,
planning, and information about lean. The study sample consisted of 131
employees working in private hospitals, and the study adopted the
quantitative approach, and many statistical methods were used, such as
descriptive statistics. The results of the study showed that there are
many challenges and obstacles that limit the application of the lean
management philosophy, such as the management role, the administration
bears the greatest responsibility for not applying the philosophy of
lean management in an appropriate manner, through the lack of commitment
and support on the part of senior management with regard to the
mechanism of applying lean management. Also, one of the factors that
greatly affect the lack of application of lean management is the people
construct; so there are many private hospitals that do not focus on the
participation of their employees in their decision-making at times. In
addition to the weakness in resources management, the lack of strategies
and planning by the administration in hospitals, and the lack of
sufficient knowledge among the management and employees in lean
management. The study recommended the work of private hospital managers
to choose the best ways and methods in order to implement and implement
lean management, this is within the framework of defining strategic
goals and priorities that form the basis of all hospital systems.
Effects of a Personalized Anti-Drinking Mobile Game on College Students’ Responses to Binge Drinking: Mediating Roles of Self-Referencing Effects and Flow
Authors: Lee Joonghwa
Published: April 2023

This study suggests that a personalized anti-drinking mobile game can be effective in addressing college students’ binge drinking perceptions, as it can generate higher levels of self-referencing effect and flow. This study conducted a post-test only experiment with the personalized mobile game condition by using a participant’s selfie and name and the control condition by using a default game character. This study found that (1) the personalized mobile game generated a higher level of self-referencing effect than the default mobile game; (2) the self-referencing mediated the positive effect of the personalized mobile game on attitudes toward the game and the negative effect of it on attitudes toward binge drinking; and (3) the personalized mobile game generated higher levels of self-referencing effect and flow than the default mobile game, which in turn resulted in more positive attitudes toward the game. The implications of these results are discussed.
Tobacco Risk Perception and Risk Information Factors: Comparison of Cigarette, Alternative, and Multiple Tobacco Users
Authors: Jun Jungmi
Published: April 2023

This research compares various tobacco user groups’ tobacco risk perception and tobacco risk information factors; information seeking, sources, and trust in sources. Additionally, tobacco risk information factors that are associated with tobacco risk perception were identified. A nationally representative sample from the 2015 Health Information National Trends Survey (HINTS)-FDA was employed. All users (including cigarette users) rated cigarettes as the most harmful and electronic cigarettes as the least harmful tobacco product. Alternative tobacco users rated their own product (i.e., smokeless, cigar) as the second least harmful compared to other products, and their risk rating of their own product was significantly lower than that of other users. Users of multiple tobacco products reported the highest risk perception, but they were more likely to be young adults with racial/ethnic minority backgrounds ascribing more trust to information from tobacco companies. A recent search of cessation information, greater exposure to risk information from television, newspapers, and public transportation, and higher trust in healthcare providers were associated with increased tobacco risk perception. Future interventions need to address the lack of risk perception for alternative tobacco products, optimistic bias among alternative tobacco users, and tobacco user groups’ different needs and source preferences for risk information.
The Effects of Physical Poses on Risk-Taking Behaviors and Signature Size after Playing with a Motion-Controlled Video Game
Authors: Chen Meng , Pena Jorge
Published: April 2023

Though researchers have investigated how video games impact players’ subsequent cognition and behavior, fewer studies have explored how enacting physical gestures when playing motion-controlled games leads to downstream impact. Participants who played while performing power poses showed greater risk-taking tendency compared with those who kept powerless poses. However, both power and powerless conditions showed reduced signature sizes compared with baseline signature. The findings highlight the role of game mechanics in affecting ensuing behavior and provide evidence that physical gestures involved in playing video games can impact offline risk behaviors.
Prejudiced responses in patient-physician communication? no evidence for across-the-board unintended effects in majority patients
Authors: Arendt Florian
Published: April 2023

There is evidence indicating that ethnic concordance in patient–physician communication beneficially contributes to positive outcomes in minority patients. As minority patients tend to have less positive health outcomes compared to majority patients and reducing health inequalities is a global imperative, striving for the establishment of a more diverse physician workforce can be deemed a valuable public health goal. Research has yet to show that there are no undesired unintended effects in majority patients. In fact, majority patients might show less positive outcomes when interacting with a minority physician based on their prejudice. We conducted a web-based experiment in which individuals (N = 305 German “majority” patients) were randomly assigned to a hypothetical medical consultation in which a physician—Dr. Çağdaş Kılıç (“minority” physician condition) or Dr. Thomas Kirsch (“majority” physician condition)—talked about lifestyle factors associated with chronic non-communicable diseases. Using equivalence testing, we found no substantial differences regarding beliefs toward the physician, reactance-related outcomes, and prevention-related knowledge transfer between both experimental conditions. Therefore, the present study provides no evidence for across-the-board unintended effects in majority patients. This finding supports the establishment of a more diverse physician workforce as a valuable public health goal.
Sensory sensemaking : a study of fitness bands and its quantified body representation of young Indians
Authors: Rajan Benson
Published: April 2023

There has been an explosion of wearable fitness-tracking consumer devices in India. The body and its functions are now visually analysable using these bands. The notion of being mindful about the body is fused with a fitness culture. This culture is supported by a growing market for fitness commodities that work towards transforming the self into computable data. This paper attempts to explore the manner in which fitness tracking devices enable positive reinforcement in young Indians. The primary means of data collection for the study was in-depth interviews with young adults (18 to 25 years of age). The participants expressed an affective relationship with the devices, especially the impact of data visuals that was a motivational factor in improving user performance. The study uses the Self-Determination Theory to map user motivation around fitness devices. The qualitative findings revealed the usage of fitness trackers in young Indians to be a private endeavour. While participants felt a positive sense of agency with the devices, they were also averse to the idea of competing within virtual fitness community.
Cancer Types: Their Social Media Coverage, Incidence and Distortion in French-Speaking Countries of the West*
Authors: Pelletier Karen , Zimmerli Virginie
Published: April 2023

This article investigates the coverage of different types of cancer on two major social networks sites, Facebook and Instagram. A categorical content analysis is performed on a corpus of 2,446 posts collected via a web listening tool on these two social media. The primary objective is to assess the coverage of different types of cancer on these social media. The second objective is to detect any distortions between this social media coverage and the number of new patients (incidence rate) in French-speaking countries of the West in 2020. Our results highlight the predominance of breast cancer coverage (18.3%), pediatric cancer (9.7%), leukemia (4.2%), but also the over-representation of female cancers accompanied by an under-representation of male cancers and urological cancers. Insofar as the efforts of groups defending certain diseases create a considerable impact on social media— and subsequently on the public agenda — it is of paramount importance to draw the attention of policymakers, scientists, and organizations on these representation gaps (distortions), by further engaging, for instance, communities around less visible cancers.
A Techno-Socio Exploration of Mental Health Communication on Social Media
Authors: Nattembo Anne
Published: April 2023

Drawing on the social media affordance construct, this paper presents a deeper understanding of the process of producing, circulating, consuming, and reproducing mental health information on social media. The paper examines mental health-related subreddits, Facebook pages, and online website forum threads. This paper goes beyond the binary perspective of identifying positive or negative effects of using social media on mental wellbeing to interrogate how social media affordances shape and are shaped by the communication process. The findings show that social media affordances shaped production, circulation, consumption, and reproduction processes through three main aspects namely sustaining already existing mental health information, and to a less extent creating opportunities for new information to emerge as well as sustaining dominant asymmetrical relations of power.
Guest editorial: Machine learning-based decision support systems in IoT systems
Authors: Chen Mu-Yen , Rubio Jose , Ivanovic Mirjana
Published: April 2023

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Physicochemical evaluation and microbiological properties of artisanal Yoghurt sold in Maroua-Cameroon
Authors: A Tagne Tadié
Published: April 2023

Malnutrition remains a real health problem in the Far North Region of Cameroon despite the presence of many food commodities. The objective of this work was to evaluate physicochemical and microbiological properties of ten artisanal yoghurt (kossam) sold in Maroua-Cameroun. Proximate composition, viscosity and titratable acidity were determined by standard Association of Official Analytical Chemists (AOAC) methods. Mineral contents: calcium, magnesium, sodium, potassium, iron, zinc and manganese were determined by atomic absorption spectrophotometry and phosphorus by Murphy Riley reagent. The microbiological analyses were carried out following the standard protocols. Analysis of variance revealed a significant difference in the levels of the parameters analysed in the different yoghurt samples (p<0.05). The results of this study revealed for all the samples an acid pH (3.20 - 4.37); titratable acidity (2.01-2.74% ); viscosity (1.32-1.51). Other contents per 100g fresh matter are as fellow: Moisture (87.29- 92.45%); Protein (2.02-3.72g); Carbohydrate (4% for all the samples); ashes (0.28-0.49g); calcium (74-113mg); magnesium (4-20mg); zinc (0,117-0,333mg); potassium (60.4-165mg); sodium (10- 17,25mg); iron (0.034-0.088mg) and phosphorus (51-80mg). The microbiological analyses revealed that fungal flora were only detected in few samples (1.2-4.47 log10cfu/ml); Total aerobic mesophilic flora (4.36 -9 log10cfu/ml); Staphylococcus (1.30-5.31 log10cfu/ml) and total coliforms (1- 3 log10cfu/ml). These yoghurts could therefore contribute nutrients for human nutrition and for the management of some nutritional diseases.
Ready-To-Eat Flakes from Acha, Partially Defatted Sesame Meal and Modified Corn Starch: Modeling, Optimization and Characterization
Authors: O Fasuan Temitope
Published: April 2023

In this research, ready-to-eat flake from a blend of acha, partially defatted sesame, and modified corn starch was modeled, optimized and characterized. The study aimed to develop a design model that would give a healthy ready-to-eat flake. The formulated flour mixtures were developed into ready-to-eat flakes. Mixture experimental design of the response surface methodology was employed. Characterization of the flake showed protein (14.01g/100g), fat (8.69g), fibre (1.23g), ash (5.03g), moisture (9.45g), carbohydrate (61.50g), sodium (92.03mg), calcium (142.50mg), potassium (201.11mg), iron (110.01mg), zinc (85.32mg), thiamine (0.12mg), niacin (9.81mg), folic acid (2.16mg), pyridoxine (1.81mg), and acceptability index (90.10%). The high essential amino acid index (>90%) showed that the product is a good protein-source. The study showed the feasibility of formulating ready-to-flakes with good protein and high acceptability index using acha, partially defatted sesame, and modified corn starch. The production process is scalable and could be employed for both domestic and industrial purposes.
The Hypocholesterolemic and Glucose Modulatory Effect of Fibre Enriched Snack in Hyperlipidemic/Hyperglycemic Rat Model Induced by High Cholesterol and High Fructose Diet
Authors: OO Adetoboye
Published: April 2023

Dietary interventions have been used in the management of hyperlipidemia. Incorporation of dietary fibre into food products enhances their nutritional value. This study was done to investigate the effect of a fibre enriched snack on the blood glucose level and lipid profile in hyperlipidemia-hyperglycemia - induced wistar albino rats. The rats (n=25) were divided into 5 groups, 1 - fed standard laboratory diet (Control), 2 - fed hyperlipidemic diet and 10% fructose solution, 3 - fed hyperlipidemic diet, 10% fructose solution alongside fibre enriched snack, 4- fed hyperlipidemic diet which was withdrawn before feeding fibre enriched snack, 5 - fed standard laboratory diet and fibre enriched snack, 6 - fed hyperlipidemic diet, 10% fructose solution and a conventional antilipemic drug (CAD). The duration of the experiment was for 6 weeks. Statistical analysis was done using graph pad prism 6.01 version. At the end of the experiment, it was found that the fibre enriched snack stabilized blood glucose levels, reduced serum total cholesterol (TC) (p<0.01) and low density lipoproteins (LDL) (p< 0.01) in the hyperlipidemic diet fed group. There was, however, no significant change in the triglycerides (TG) as well as the high-density lipoproteins (HDL) in the hyperlipidemic group fed with the fibre enriched snacks. The results indicate that the fibre enriched snack has hypoglycemic and hypolipidemic potential and could, therefore, serve as an effective dietary intervention in the management of diabetic dyslipidemia
Production and Evaluation of Selected Chemical Properties of Some Fermented Chemically Peeled Yellow-Fleshed Cassava Products
Authors: NU Arisa
Published: April 2023

Cassava (Manihot esculenta Crantz) has varying sizes and shapes leading to difficulty in peeling mechanization. This study was carried out to investigate the effect of chemical peeling on some chemical properties of some fermented yellow- fleshed cassava roots products. Cassava roots (IITA-TMS-IBA070593) were dipped in 15% NaOH solution (96o C, 5 minutes), softened peels were removed by brushing under running water and neutralized with 3% citric acid solution or with sharp stainlesssteel knife. Batches of peeled roots were fermented into gari or fufu. Some quality characteristics of the peeled roots and products were determined. Gari produced had sodium content of 40.91 or 41.47mg/100g respectively for knife or chemically peeled cassava. Ca and P contents increased in gari but were lower in fufu. Percentage carotenoid retention were 62.62% and 70.21% for gari and 47.89% and 58.53% for fufu. Chemical peeling had no adverse effects on quality characteristics of gari and fufu produced.
Induced Breeding Practices of the Freshwater Fish Hatcheries in Bangladesh
Authors: BK Chakraborty
Published: April 2023

This study was conducted on the fish hatcheries of the 8 division of Bangladesh to identify about induced breeding practices of different hatcheries. About 6 native species viz. Rui (Labeo rohita), Catla (Catla catla), Mrigel (Cirrhinus mrigala), Calibaush (Labeo calbasu), Bata (Labeo bata) and Gonia (Labeo gonius), 7 exotic species viz. Silver carp (Hypopthalmicthys molitrix), Bighead carp (Hypopthalmicthys molitrix), Grass carp (Ctenopharyngodon idella), Common carp (Cyprinus carpio), Black carp (Mylopharyngodon piceum), Thai pangus (Pangasius sutchi), Thai puti or raj puti (Barbonymus gonionotus) and 06 Indigenous species pubda (Ompok pabda), Gulsa (Mystus cavasius), Tengra (Mystus tengra), Koi (Anabas testudineus), Shing (Heteronopneustes fossilis) and Magur (Clarius batrachus) were recorded for the induced breeding practice of fresh water of Bangladesh. Three types of inducing agents viz. PG (Pituitary Gland), HCG (Human Chorionic Gonadotropin) and GnRHa (Gonadotropin Releasing Hormone analogues) were used for induced breeding. Ovulation rate of Indian major carps and other exotic fish species were 65, 70, 74, 80, 84, 88, 92, 96, 98, 90 and 88%, respectively. The regression type is Polynomial and the equation is y = -0.751x2 + 11.36x +49.705 (R2 = 0.8449). The hatching rate were recorded at the rate of 52, 55, 62, 71, 77, 80, 86, 90, 94, 80 and 62%, respectively in different hatcheries and the regression type is Polynomial and the equation is y = -1.1254x2 + 15.96x +29.182 (R2 = 0.8328). The ovulation rate of 06 Indigenous fish species were 70, 76, 81, 84, 86, 88, 97, 98, 99, 90, 84 and 70%, respectively. The regression type is Polynomial and the equation is y = -1.0082x2 + 12.96x + 53.97 (R2 = 0.8749). The hatching rate were recorded at the rate of 58, 61, 72, 76, 82, 91, 93, 94, 73, 68 and 6%%, respectively. The regression type is Polynomial and the equation is y = -1.289x2 + 16.269x +36.958 (R2 = 0.849).
Role of Biofloc on Immuno Modulatory Responses of Cultured Aquatic Organisms
Authors: AM Babitha Rani
Published: April 2023

Intensification in aquaculture is the need of the hour to meet demand of protein by the population which is increasing at an exponential rate
The Adverse Effects of Underwater Sound upon Fishes and Invertebrates
Authors: Hawkins Anthony
Published: April 2023

Underwater sound is very important to most fishes and invertebrates. Underwater sounds from both natural and human sources can have adverse effects upon aquatic animals, and especially fishes, and invertebrates. It is important to examine the effects of sound upon them, and especially the effects of sounds derived from human sources (anthropogenic sounds). It may be possible to introduce protective regulations to reduce their effects. Fishes and invertebrates can detect underwater sounds, and they use sound to obtain key information about the environment around them. They can also make sounds themselves, especially during their spawning. Sounds travel rapidly over great distances in water and can provide detailed information to these animals on the presence of prey, predators, and related species, while the overall acoustic scene provides them with key information about their environment. Anthropogenic sounds can be very harmful, and it is therefore important to deal with them. A succession of reports and scientific papers have emphasised the risks to these animals from exposure to man-made sounds or noise and will be mentioned in this paper, which also deals with the Criteria and Metrics for assessing the effects of underwater sound on fishes and invertebrates.
Epidemiological Study of Molecular and Genetic Classification in Adult Diffuse Glioma
Authors: Faraji-Rad Mohammad
Published: April 2023

Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and isocitrate dehydrogenase 2 (IDH2) are frequent in lowgrade and high-grade gliomas. However, the diagnostic criteria, in particular for gliomas, are highly various. The aim of our study was to establish genetic profiles for mutation and calcification of diffuse gliomas and to evaluate their predictive factors. Methods: We estimate the different clinical and molecular characterization between IDH1, IDH2 mutant gliomas, p53, ATRX and 1p19q. In addition, whole-transcriptome sequencing and DNA extraction data were used to evaluate the distribution of genetic changes in IDH1 and IDH2 mutant gliomas in a Iranian high grade glioma. Results: Between 2016-2019, among 53 gliomas in our study, 29 cases (54.7% %) harbored an IDH1,2 mutation, 21 cases (39.6 %) harbored an p53 mutation and 19 cases (35.8 %) harbored an ATRX. In addition, 1p19q co-deletion mutation was found in 7 cases (12.2%). We found that IDH1 and IDH2 are mutually entirely in gliomas. There was no significant relation between histopathology, tumor location and clinical finding with diagnosed mutations. Conclusion: Our study discloses an associated distinction between IDH1 and IDH2 mutant gliomas nearly in half of patients, followed by p53. These mutations should be reviewed separately because their differences could have indication for the diagnosis and treatment of IDH1/2 mutant gliomas.
Testis Sparing Surgery in Double Testicular Tumor in a Child: Report of a Case
Authors: Nunez Bernardo
Published: April 2023

Mature teratomas are the most common benign testicular tumour during childhood. Epidermoid cyst are rare benign tumours, being more frequent before adolescence. We report so far the only case of ipsilateral and synchronous mature teratoma and epidermoid cyst in paediatric age.
Digital Technologies for Management of Dementia and Future Directions
Authors: Mishra Vinaytosh
Published: April 2023

Dementia is rising like an epidemic and the global burden of the disease is increasing with each passing day. Advancement in technologies has resulted in extended life and we will witness more prevalence of dementia in these elderly people. The fastest growth in the elderly population is taking place in China, India, and their south Asian and western Pacific neighbors and this country will face a daunting task in the management of dementia soon. The prevalence of vascular diseases such as diabetes further aggravates the situation. Luckily digital health technologies are becoming mature, and many approved technologies are available for use now. This study explores the potential of these technologies and maps them as a possible solution in the management of dementia. The findings of the study are useful for clinicians, health technology researchers, and health policymakers
Usefulness of Uselessness
Authors: Favre Dre Dragana
Published: April 2023

After the first months of analytical (Jungian) psychotherapy, when the patient and the therapist have already started building their mutual relationship and creating a safe space in which the hidden can be stored, seen, and used as a cure, the more profound contents from the unconsciousness or the deeper layer of consciousness begin to appear
All the Roles of School Bullying and Empathy in an Experimental Intervention Approach
Authors: Gkatsa Tatiani
Published: April 2023

The writing presents an experiential intervention approach, focusing on all the roles of school bullying, and empathy”. In an incident of school bullying, the attitude of all those present towards the protagonists determines the development and outcome of the incident. Cognitive and emotional empathy is the mediating factor in bullying and victimization behaviors. Through the experiential approach, it is sought to educate the public, students, pupils, teachers, and parents to understand with empathy all the roles of those present in school bullying and to actively transform their attitude. The method applied is Forum Theater and Storytelling techniques, role play and frozen image and Transformation of History in Forum Theater. Dramatized scenes and frozen images facilitate the Recognition, Understanding, Labeling, Expression, and Resilience (RULER) of thoughts, and feelings, through these develops empathy and resilience. The facilitator prompts the participants to talk in a supportive and complementary way to the victimized student and the bully. It is expected the development of psychosocial skills and conflict coping strategies.
Parenting While Grieving: The Experience of Widows with Young Children
Authors: Williams Christian
Published: April 2023

The death of a spouse while parenting young children brings unique challenges for the widow who must not only grieve the loss of a partner but also navigate the demands of solo parenting and help their children through the grieving process. The multiple layers of losses place young widows at risk for the development of mental health issues such as depression and anxiety and negative health trajectories. Bereavement outcomes are influenced by the practical and emotional resources that a widow has available to them as well as the strength of their social support network. This qualitative study explored the grief experiences of widows with young children and the factors that influenced adaptation post-loss. Open ended survey questions were used to gather data from 232 widows and thematic analysis was used to identify themes in the data. All of the themes centered on the multiple layers of grief that must be navigated as widows adapt to being a solo parent and the practical and emotional challenges that they experienced. The widows identified that they were simultaneously grieving the loss of their spouse, while helping their children manage the grieving process, and grieving the life, plans, and opportunities that the death of their spouse had taken from them. While the demands of parenting increased challenges to adaptation and increased experiences of self-doubt, parenting was also identified as a role that had a positive impact on bereavement, helping the widows to remain engaged in their lives as they navigated this difficult journey.
Analysis of Psychological Resilience of TFF U16 Development League Soccer Players
Authors: Gümüşdağ Hayrettin
Published: April 2023

The aim of this research is to analyze the psychological resilience levels of football players playing in the U 16 development league within the Turkish football federation. Scanning model was used in the research. The sample of the research consists of 160 active players of eight teams in the men’s U16 development league of the Turkish football federation in the 2022-2023 season. As a data collection tool in the research, a personal information form stating the education status of the football players, the year of playing football, working with the same coach and monthly family income, as well as the “Psychological Hardiness Scale” (PHS) developed by Işık S was used to collect quantitative data. The resilience scale consists of three sub-dimensions: dedication, control and challenge. The normality distribution was tested by applying the kurtosis and skewness test to the data. T-test and ANOVA tests of the data were performed and multiple comparisons (Post-HocTukey) and correlation analysis were used. Statistical significance level was determined as 0.05. As a result of the research, the psychological resilience of the individuals who do sports at the elite level was significantly higher. In the education variable, psychological resilience was found to be positive in those with a high education level. A significant and low level positive relationship was found between the variables of playing football and working with the same coach. It is thought that this study can contribute to the fieldwork aimed at making suggestions to athletes with low resilience and increasing their resilience levels.
Address Terms Used by Local People in Menyali Village
Authors: Gede Bagus Kresnantara  , I Gede Budasi  , Ni Putu Astiti Pratiwi
Published: April 2023

The use of greeting terms in each region is different and this is influenced by social factors. This is a recent phenomenon that is interesting for further research. This study was aimed to analyze the types of address terms used in Menyali village and the social factors which influenced those address terms. Descriptive qualitative was used as the method of this study. The data were collected by conducting observation and interview through the use of observation sheet and interview guide as the instruments. There were three local villagers involved as the informants of this study. They were selected by using purposive technique sampling. The collected data were analyzed by using qualitative data analysis through data reduction, data display, and conclusion drawing. The findings showed that; 1) there were twelve types of address terms spoken by people in Menyali village; kinship terms, special nicknames, pet names, title only, first names, intimacy names, respect names, mockery names, pronouns, occupational terms, religious terms, zero address terms, 2) there were seven social factors influenced the address terms used in Menyali village; sex, family relationship, occupational hierarchy, age, social status, the official position of the interlocutor as the second person, and ethnicity.
Implementing the Hangman Game in Teaching English Vocabulary to Elementary School Students
Authors: Weda Dharmayasa I Nyoman
Published: April 2023

Vocabulary is an important part of language, but in fact, students find it difficult in understanding the vocabulary, especially the fifth-grade students. The Hangman game might inspire pupils to study harder and focus more on the lessons being taught. The objective of the research was to analyze the significant effect of the use of the Hangman game as the media to teaching English vocabulary to fifth-grade students. The method of this research was pre-experimental research with one group and the data were collected through the pre-test and the post-test design. The researcher analyzed the data by using SPSS 26.0 version. The result of the study showed a significant increase in vocabulary mastery of the students. The mean score of the pre-test was 32.89 meanwhile the pre-test score was 81.84. Then the improvement of the students' vocabulary was 48,95%. Which means the post-test score mean score was greater than the pre-test mean score. The paired t-test result was able to be concluded that the value of Sig. (2-tailed) is 0.000 indicates that the t-value was lower than the significant alpha (α = 0.05), the null hypothesis (Ho) was rejected. Meanwhile, the alternative hypothesis (Ha) was accepted. Based on the research findings, it able to be concluded that the Hangman game was effective in teaching students’ vocabulary to the fifth-grade students.
Technology-Based Project-Based Learning in Teaching Content Subjects in University: A Study of Need Analysis
Authors: Untari Fatimah Dwi , Ni Nyoman Padmadewi
Published: April 2023

Technology plays an important role in the 21st century. Technology-based project-based learning is needed by lecturers in teaching content courses and analyzing learning characteristics. Therefore this study aims to analyze the conceptual framework for implementing technology-based project-based learning needed in teaching content courses in tertiary institutions. The subjects of this study were several lecturers at the STKIP Agama Hindu Singaraja which included four lecturers who taught content courses. This study used a mixed methods approach paradigm with a mixed methods explanatory design, in which the qualitative research design was more dominant. The instrument used in the data collection process is a questionnaire for quantitative research. Whereas qualitative research uses interview guidelines in which the questions to be asked have been prepared and there is also an analysis of documents such as syllabus, semester lesson plans, and lecture contracts. In analyzing the data, the researcher also uses the OEM (Organizational Elements Model) and CIPP models which analyze data based on context, input, process, and product. Researchers analyze based on current conditions and expected conditions so that the needs of each lecturer are known when teaching content courses. The results of the research that has been collected are the lack of readiness between lecturers and students in implementing project-based learning in the classroom. Therefore, institutions need a conceptual framework regarding the implementation of technology-based project-based learning so that the content provided must be in accordance with 21st century skills where the focus of this learning is students.
ПОЕТИКА ІНТИМНОЇ ЛІРИКИ ЛЮДМИЛИ КУДРЯВСЬКОЇ
Authors: Ференц Надія
Published: April 2023

У статті розглядаються мотиви та художні особливості інтимної лірики Л. Кудрявської. Відзначено, що інтимна лірика займає провідне місце у її творчості. Починаючи з першої збірки «Баллада о ромашке» (1964), закінчуючи останньою «Солёный глоток» (2017), Л. Кудрявська поетизує це найблагородніше почуття.Звернено увагу, що художній світ інтимної лірики Л. Кудрявської характеризується глибоким психологізмом. Поетеса розкриває психологію чутливої душі, що пізнала щастя кохання, пережила біль втрати, але зберегла почуття, пронесла його через усе життя.Зроблено висновок, що в інтимній ліриці Л. Кудрявської яскраво відображається її життєва біографія. Поетеса – людина гармонійна, неординарна і щира. Її інтимна лірика нагадує поему про любов з її радощами, печалями і розчаруваннями. Підкреслено, що майже кожен вірш Л. Кудрявської – це щира сповідь, поетична історія серця, яка не залишає байдужим читача.
ВІДДІЄСЛІВНІ НАЗВИ ОСІБ У СЛОВАЦЬКІЙ ТА УКРАЇНСЬКІЙ МОВАХ
Authors: Буднікова Леся
Published: April 2023

У статті розглядається творення віддієслівних атрибутивних та аґентивних назв осіб у словацькій та українській мовах. У розвідці показано механізм творення атрибутивних та аґентивних назв осіб праслов’янськими суфіксами, а також визначені продуктивні та непродуктивні словотвірні моделі
ПРО КОМПОНЕНТ-СИМВОЛ У МОВНИХ ОДИНИЦЯХ
Authors: Венжинович Наталія
Published: April 2023

Стаття присвячена опису теоретичного підґрунтя для вивчення компонентів­символів у мовних оди­ницях. Актуальність дослідження зумовлена особливою значущістю назрілих проблем, що стосуються співвідношен­ня мови, мислення, пізнання й культури. У статті йдеться про те, що фразеологічні символи є невід’ємним складником символів культури, але в межах фразеологічних систем вони набувають специфічного навантаження. Унаслідок огляду теоретичного доробку відомих українських та зарубіжних учених авторка акцентує увагу на їхніх твердженнях про те, що специфіка фразеологічної символіки відзначається системністю, організована за принципом ієрархії, асиметрична щодо інших символічних систем в межах певної лінгвокультури
УНІВЕРСАЛЬНІСТЬ І ВНУТРІШНЯ ФОРМА ФРАЗЕОЛОГІЧНИХ МОДЕЛЕЙ
Authors: Полюжин Іван
Published: April 2023

Статтю присвячено дослідженню засобів творення універсальності та внутрішньої форми фразеоло­гічних моделей, що складають мовну картину світу і є підсистемою, в якій кожна фразема виконує певні функції в опи­сі реалій навколишньої дійсності. Місце кожного усталеного звороту в цій підсистемі визначає як його екстралінгваль­ний зміст, так і системний характер самої мови, який регулює відношення між різними мовними знаками. Властивість універсальності базується на твердженні про те, що у світі немає мови, в якій би не було усталених зворотів, у яких простежується невивідність цілісного значення фраземи з суми лексичних значень її компонентів та їхньої семантич­ної сполучуваності. У фразеологічній моделі людина усвідомлює себе невід’ємною частиною навколишнього світу і сприймає його як відображення свого існування. Внутрішня форма при цьому є образним описом предмета, явища або фрагмента світу, на тлі яких цілісне значення лексики сприймається як узагальнено переносне. Образність внутрішньої форми, що мотивує загальну цілісність семантики фразеологічної одиниці, спирається на наявність механізму порів­ няння реалій у позамовній дійсності, які стають еталоном або антиеталоном якості, стану, дії чи описуваної ситуації.Автор доходить висновку про те, що фраземи у стислій формі своїх моделей здатні фіксувати, зберігати в собі й передавати великий обсяг різноманітної інформації, яка віддзеркалює як універсальний, так і унікальний та неповтор­ний досвід життя різних народів, окремих їх представників і навіть цілих поколінь.
ПОЕТИКА ПОВІСТІ МИХАЙЛА ГАФІЇ ТРАЙСТИ «У НІЧ НА СВЯТОГО АНДРІЯ»
Authors: Вотьканич Мар’яна
Published: April 2023

У статті проаналізовано особливості композиції, елементи міфологізму, зокрема, авторську інтерпретацію образу вовкулаки, жанрово-стильову своєрідність повісті «У ніч на святого Андрія» українськомовного письменника Румунії Михайла Гафії Трайсти. З’ясовано риси готичної прози та детективного жанру у творі, наголошено на інтертекстуальному характері окремих фрагментів повісті
ЕПІСТОЛЯРНА ПУБЛІЦИСТИКА ШІСТДЕСЯТНИКІВ
Authors: Загоруйко Наталія
Published: April 2023

У пропонованій статті здійснено спробу розглянути епістолярну публіцистику шістдесятників крізь призму альтернативного дискурсу 1960‒1980-х років. Проаналізовано та визначено особливості альтернативного дискурсу таборової епістолярної публіцистики, з’ясовано ключові аспекти цього листування. Амплітуда порушуваних проблем та широке коло адресатів листування шістдесятників засвідчує публіцистичність цього епістолярію та є органічним продовженням публіцистичної спадщини дисидентів загалом, а ідейна спрямованість кореспонденцій дає підстави зараховувати їх до альтернативного дискурсу на противагу офіційному (радянському).
ПРОФЕСІЙНА КУЛЬТУРА МАЙБУТНІХ ФАХІВЦІВ МАС-МЕДІА: ВІД ТЕОРІЇ ДО ПРАКТИКИ
Authors: Миколаєнко Надія
Published: April 2023

Статтю присвячено формуванню професійної культури майбутніх фахівців мас-медіа. Охарактеризовано аспекти професійної культури. Зазначено основні функції професійної культури фахової діяльності ЗМІ. Проаналізовано принципи для розробки моделі формування професійної культури майбутніх фахівців мас-медіа. Презентованопрактичний досвід підготовки журналістів і редакторів на базі Житомирського державного університету імені Івана Франка. Зауважено, що формування професійної культури майбутнього фахівця мас-медіа – це системний процес, що передбачає розвиток особистісних якостей і врахування усіх фахових завдань і вимог та їх реалізацію через форми й методи.
ВІТАЄМО ПРОФЕСОРА ВАЛЕНТИНУ ІВАНІВНУ СТАТЄЄВУ З ЮВІЛЕЄМ!
Authors: Венжинович Наталія
Published: April 2023

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