bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Mentorship and Reflection in Leading Learning Through Making
Authors: Lock Jennifer , Fedorko-Bartos Kristi-Mari , Turner Kristal Louise , Wise Kathy
Published: June 2022

There is a growing trend of learning through making in P-16 education in both formal and informal learning environments. In the informal learning environments, who provides support and mentorship for learning through making? In this chapter, the authors report on a maker mentor pilot project using a self-study methodology. This initiative was designed to develop knowledge and skills using a mentoring approach to support learning through making with pre-service and in-service teachers, and to model reflective practice. Using a reflective process, they share insights into the work of maker mentors, what worked well, as well as recommendations to enhance this mentoring initiative. They conclude with three implications for practice in support of the role of maker mentors.
Making and Modalities
Authors: Vallera Farah L. , Harvey Chris
Published: June 2022

The World Economic Forum's 2018 report indicated that students will need to be prepared for a rapidly changing, technology-filled world in which their future jobs likely do not yet exist. Recent education reform initiatives have focused on preparing the workforce for 21st century jobs by improving STEM literacy and acknowledging the importance of teacher preparation. Unfortunately, many teachers, designers, and technologists have not been trained in the same ways as they are expected to prepare students, and training opportunities are often delivered in traditional, business-as-usual formats. To better prepare individuals to prepare students, reimagining traditional educational delivery and modalities, while integrating STEM, making, and play to encourage the development and practice of 21st century skills may prepare those adult learners build toward the future. This chapter will discuss administrative and curricular changes we made geared toward meeting our adult audiences' needs in a teacher education program following their learning preferences.
Usable-Security Assessment of Healthcare Software System Through Fuzzy ANP-TOPSIS Method
Authors: Seh Adil Hussain , Ahmad Masood , Nadeem Mohd , Pandey Abhishek Kumar , Agrawal Alka , Kumar Rajeev , Khan Raees Ahmad
Published: June 2022

To address this research possibility, the present empirical study undertakes the assessment of usable-security of healthcare software system. The attributes considered for the assessment are: four factors at first level; thirteen sub-factors at the second level with six Hospital Management Software Systems (HMSS) as alternatives. Fuzzy Analytic Network Process (F-ANP) has been applied for evaluating the weights of the attributes and their relationship with one other. Finally, fuzzy Technique for Order of Preference by Similarity to Ideal Solutions (F-TOPSIS) technique has been applied and alternatives ranking has been estimated. Results of the study conclude that HMSS-1 provides better usable–security. Furthermore, as analysed, F-TOPSIS produced more convincing results in assessing the usable-security of the HMSS. This research analysis also corroborates that when compared with the Classical ANP TOPSIS, the Fuzzy-ANP TOPSIS is the ideal methodology for producing accurate results.
Factors Influencing the Acceptance and Use of Internet of Things by Universities
Authors: Ajigini Olusegun Ademolu
Published: June 2022

Internet of Things (IoT) is a new concept bringing revolution to higher educational institutions through its usage by providing smart education and better learning outcomes. It has generated new interest and complexities for researchers as well as academicians in higher educational institutions. In this paper, factors influencing the acceptance and usage of IoT in higher educational institutions were developed. Additionally, a model for consenting and using IoT in higher educational institutions was developed. This study laid a foundation for a comprehensive model based on the UTAUT framework. Regression analysis was carried out to obtain the factors that predicts the acceptance and usage of IoT in higher educational institutions. All test results were reliable and valid. The study demonstrates how university administrators can use IoT technologies to improve educational operations and outcomes.
Deep Unsupervised Weighted Hashing for Remote Sensing Image Retrieval
Authors: Jing Weipeng , Xu Zekun , Li Linhui , Wang Jian , He Yue , Chen Guangsheng
Published: June 2022

Deep unsupervised hashing methods are gaining attention in the field of remote sensing (RS) image retrieval due to the rapid growth in the volume of unlabeled RS data. Most previous unsupervised hashing research used only natural image-based pre-trained models to generate label matrices; however, this method cannot capture the semantic information of RS images well and limits the accuracy of retrieval. To solve this problem, the authors propose a deep unsupervised weighted hashing (DUWH) model that uses a similarity matrix updating strategy based on a weighted similarity structure to achieve the mutual optimization of the similarity matrix and hash network. The authors devise a novel combinatorial loss function to improve the hash performance that can be used to obtain higher quality hash codes by assigning different weights to the sample pairs with different difficulties. Experiments were conducted on two RS datasets to verify the excellent performance of the proposed method.
Reading into the future and preparing for it
Authors: Hungin Pali
Published: June 2022

No abstract available
Picture quiz – Answers
Authors: Sriskantharajah Sunantha , Fernandopulle Nilesh
Published: June 2022

No abstract available
A Hemagglutinin 1 Carrying Plant-Based Virus-like Particle Vaccine Generates an Efficacious Cellular Response by Exploiting IL-1 Signaling in Both Adult and Aged Mice
Authors: Alvarez Fernando , Istomine Roman , Hendin Hilary , Hodgins Breanna , Pillet Stephane , Fritz Jörg H , Charland Nathalie , Ward Brian J , Piccirillo Ciriaco A
Published: June 2022

Inactivated influenza vaccines have struggled to provide consistent protection in older individuals. Circumventing immune senescence, an aging of the immune response characterized by weak humoral responses to vaccines, and unchecked inflammation during infection require novel immunization strategies. Plant-based virus-like particles (VLPs) bearing recombinant hemagglutinin proteins have been shown to provide protection in older animals in preclinical challenge studies, despite eliciting relatively low or absent humoral responses. The nature of the cellular response induced by these vaccines and its evolution during infection have not yet been fully characterized, however. Using a murine model that recapitulates features of human immune senescence, we assessed T cell responses to vaccination with a VLP bearing the hemagglutinin of H1N1/California 07/2009 (H1-VLP) before and after challenge in young and aged BALB/c mice (2 and 18 mo old, respectively). We report that two i.m. doses of H1-VLP (3 μg) vaccine 21 d apart generated H1-specific Th1 and Th2 cells associated with the prevention of prolonged pulmonary inflammation and mortality in both adult and aged mice. While investigating the regulation of cellular immunity, we identified a unique IL-1R1+ tissue-adapted regulatory T cell population in the lungs of both H1-VLP–vaccinated adult and aged mice, suggesting a novel regulatory T cell population associated with vaccine-mediated protection. Collectively, this study provides preclinical evidence that the plant-based H1-VLP vaccine may act, in part, by preventing exacerbated immune responses against influenza A.
Perclose ProGlide devices simplified the removal of the femoral venous cannulas for the transcatheter closure of atrial septal defect
Authors: Han Xiaofeng , Guo Xi , Li Tiezheng , Liu Guangrui
Published: June 2022

OBJECTIVE:

This study aimed to assess the effectiveness, feasibility, and security of the Perclose ProGlide device that was used to remove the femoral venous cannulas for the transcatheter closure of atrial septal defect (ASD).

METHODS:

A total of 145 cases were analyzed retrospectively, who performed transcatheter closure of ASD in our center from March 2019 to March 2021. Based on whether the Perclose ProGlide device was placed or not in the femoral vein, 48 patients were assigned to the Perclose group and 97 ones to the non-Perclose group. The data of general characteristics, femoral venous cannulas, and related puncture complications were compared between the two groups.

RESULTS:

The data of general characteristics or femoral venous cannulas were not significantly different between the two groups, but the procedure duration of removing venous cannulas was shorter in the Perclose group (0.5 min [0.35, 0.70] vs. 5 min [3.6, 7.4], P < 0.001). The puncture procedure-related blood lose was not significantly different between the two groups (Hemoglobin reduction value: 0.10 [−0.47, 0.30] g/dL vs. 0.10 [−0.50, 0.30] g/dL, P = 0.905). In addition, other complications caused by the removal of venous cannulas, length of stay in the ward, puncture infection, reintervention, and so on were not significantly different between the groups.

CONCLUSIONS:

The Perclose ProGlide device could simplify the removal of femoral venous cannulas for ASD transcatheter closure by decreasing procedure duration and time in bed. The efficiency, feasibility, and safety of Perclose ProGlide devices, which were used to remove venous cannulas, are good enough for their clinical application.
Case report of type IIIa endoleak after endovascular aortic repair
Authors: Han Xiaofeng , Guo Xi , Liu Guangrui , Li Tiezheng
Published: June 2022

An 81-year-old male presented to our emergency department for abdominal pain and distension. The patient had previously undergone endovascular aortic repair (EVAR) procedure 9 years ago for infrarenal abdominal aortic aneurysm with regular follow-up in postoperative. Three years ago, computed tomography angiography (CT) revealed Type Ib endoleak with right common iliac artery expansion and Type II endoleak from inferior mesenteric artery (IMA). Then, the patient was successfully treated by relining the iliac stent-graft to cover the common iliac expansion and coil embolism to occlude IMA through the Riolan's arch using endovascular technique. Recently, the following up CTA displayed a new Type IIIa endoleak, which the left iliac limb was disconnected with the main body graft. The patient was ultimately successful to treat by implanting stent-grafts using endovascular therapy. This case emphasizes the necessity of follow-up examination for lifelong stent-grafts surveillance. We debated the current late-related complication of EVAR and stent-graft migration treatment choices.
Application of a custom-manufactured directional multibranched stent graft to treat thoracoabdominal aneurysms
Authors: He Hao , Li Quanming , Ye Zijian , Shu Chang
Published: June 2022

OBJECTIVE:

The objective of this study was performed to demonstrate the feasibility and effectiveness of a custom-manufactured stent graft (CMSG) with directional multibranches for the treatment of a complex thoracoabdominal aortic aneurysm (TAAA) patient.

METHODS:

A 73-year-old man presented with Crawford Type V TAAA was treated with a CMSG with four down-going directional branches including two proximal directional branches for the celiac artery and superior mesenteric artery and two distal side directional branches for the bilateral renal arteries.

RESULTS:

Postoperative course was unremarkable and 6-month follow-up demonstrated sac regression, absence of endoleaks, and all of the visceral branches remained patent.

CONCLUSIONS:

Total endovascular repair using CMSG with directional multibranches is a suitable alternative in higher risk patients with TAAA who are not suited for open surgery. Longer follow-up is needed to confirm the preliminary results.
Fuzzy inference analysis of the arterial hypertension effect on aneurysm
Authors: Imene Bouharati , Nasser-Eddine Boubendir , Khaoula Bouharati , Slimane Laouari
Published: June 2022

BACKGROUND:

Several factors are at the root of the aneurysm. This disease is characterized by the loss of parallelism of the abdominal aorta, which widens to a breaking point. This anomaly is silent, and it is discovered by accident during the diagnosis of another patient. High blood pressure is often associated with the aneurysm. The age factor is directly linked to other factors that are often poorly understood.

SUBJECTS AND METHODS:

This study proposes the analysis of these factors by artificial intelligence techniques, in particular fuzzy analysis. This mode of reasoning compensates for the uncertainties inherent in the process. A fuzzy system is established, allowing factors recorded from 100 diagnosed patients to be entered as input variables to the system to read the predicted aortic diameter.

RESULTS:

The result at the output of the system will be as precise as possible, because, it is calculated from the aggregation of all the variables. This study compensates for imprecision and uncertainty by considering blood pressure as an imprecise and therefore fuzzy variable

CONCLUSIONS:

The result at the output of the system will be as precise as possible, because it is calculated from the aggregation of all the variables. In the absence of a systematic screening program, this system can be a tool to help prevent this disease.
Covid Induced Telogen Effluvium (CITE)
Authors: Inamadar Arun C.
Published: June 2022

Hair loss is one of the most common post-covid symptoms observed during this severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Pro-inflammatory cytokines, direct viral effect on hair follicles, and microthrombi are thought to be the pathogenic factors considered. Information regarding time of onset and severity is similar to other infection-induced acute telogen effluvium. It is reasonable to think that the evolution and prognosis are similar, and therefore, even without any specific treatment, full recovery of lost hair is expected.
Topical Gentamicin 0.1% Promotes Collagen 7 Expression in Recessive Dystrophic Epidermolysis Bullosa
Authors: Mahajan Rahul , Manjunath Seema , Madakshira Manoj G. , De Dipankar , Handa Sanjeev , Chatterjee Debajyoti , Radotra Bishan D.
Published: June 2022

Background:

Currently, there is no cure for epidermolysis bullosa (EB) but few studies have explored the role of aminoglycosides in promoting collagen 7 expression in recessive dystrophic EB (RDEB).

Materials and Methods:

Consecutive patients aged >1 year with a confirmed diagnosis of dystrophic EB (DEB) were advised to apply 0.1% w/w gentamicin cream in a collagen base (Derbriment G™) twice daily on a representative area on right lower limb (RLL) and paraffin gauze dressings on the corresponding opposite side on the left lower limb (LLL). Skin lesions were evaluated clinically during the 12-week treatment period at the end of which a repeat skin biopsy was sent for immunofluorescence antigen mapping (IFM).

Results:

Twelve patients with DEB were recruited but only eight completed the study and were analyzed. The mean fluorescence intensity (MFI) of the study cohort increased from 2765 ± 1732.07 (263–4845) at baseline to 5412.75 ± 3937.64 (2100–13536) at 12 weeks; a 95.75% (range 5.34%–775.14%) increase in the MFI of collagen 7 from baseline (P = 0.06). Among patients with a known termination codon mutation (n = 3), the percentage increase in MFI was greater among patients with known premature termination codon (PTC) mutations compared to those with unknown mutations. The clinical severity did not change significantly in terms of the mean number of blisters, erosions, and scarring during the study period. None of the parents reported any adverse effect.

Conclusions:

Topical gentamicin 0.1% w/w is a safe and effective way to promote the expression of COL7A1 in DEB patients, especially those carrying PTC mutations.
Prevalence and Pattern of Dermatological Manifestations Among Substance Users Across Kashmir Valley in North India
Authors: Aslam Aaqib , Rather Shagufta , Hussain Arshad , Younus Faizan , Saqib Najam U , Hassan Iffat
Published: June 2022

Background:

Substance use has turned out to be one of the growing social problems of the present society cutting across all sorts of boundaries of the world with Kashmir Valley being no exception to this growing pathological phenomenon.

Aims and Objectives:

To find the prevalence and pattern of dermatological manifestations among substance users across Kashmir Valley.

Materials and Methods:

Cross-sectional study where patients of all age-groups, irrespective of gender, were enrolled in the three largest districts of Kashmir Valley over a span of 18 months.

Results:

Sample size was 710 with a male/female ratio of 12.4:1. The mean age of the cases was 25.2 ± 7.05 years. Heroin, one of the opioids, was the most common substance used (n = 515), followed by cannabis (n = 334). Pruritus was found to be the most common dermatological manifestation overall and statistically significant among heroin users. Stigmata of injection drug use (IDU) with the presence of track marks and sooting tattoos (93.1%), atrophic scars secondary to skin popping (30.7%), active skin ulcers (18.8%), and puffy hand syndrome (8.7%) were specifically seen among injection drug users. Oral involvement was seen in 48.5%, including periodontal disease, oral thrush, and stomatitis nicotinica. Hyperhidrosis was present in 30%, and hesitation cuts over arms in 16.3% of all substance users.

Conclusion:

Dermatological manifestations are quite prevalent among substance users in the population of Kashmir. Pruritus with temporal relation to substance use, stigmata of injectable drug use including track marks and sooting tattoos, atrophic scars at injection sites, active skin ulcers, and skin and soft tissue infections, and hyperhidrosis are among important dermatological clues for detecting substance use. Recognition of such cutaneous signs is important in these cases for more effective diagnosis and treatment.
Mortality in patients receiving prolonged invasive mechanical ventilation time in the emergency department
Authors: Savatmongkorngul Sorravit , Yuksen Chaiyaporn , Sunsuwan Napathom , Sricharoen Pungkawa , Jenpanitpong Chetsadakon , Maijan Konwachira , Watcharakitpaisan Sorawich , Kaninworapan Parama
Published: June 2022

Background:

Patients waiting for intensive care unit (ICU) admission cause emergency department (ED) crowding and have an increased risk of mortality and length of stay (LOS) in hospital, which increase the hospitalization cost. This study aimed to investigate the correlation between mortality and invasive mechanical ventilation (IMV) time in patients in the ED.

Methods:

A retrospective cohort study was conducted in patients who received IMV in the ED of Ramathibodi Hospital. The correlation between mortality at 28 days after intubation and IMV time in the ED was analyzed. The cutoff time was analyzed to determine prolonged and nonprolonged IMV times. ICU ventilation time, length of ICU stay, and LOS in the hospital were also analyzed to determine their correlations between IMV time in the ED.

Results:

In this study, 302 patients were enrolled, 71 died, and 231 survived 28 days after receiving IMV in the ED. We found that the duration of >12 h of IMV in the ED increased the 28-day mortality rate by 1.98 times (P = 0.036). No correlations were found between IMV time in the ED and ventilation time in the ICU, length of ICU stay, and LOS in the hospital.

Conclusion:

More than 12 h of IMV time in the ED correlated with mortality at 28 days after initiation of IMV. No associations were found between prolonged IMV time in the ED with ventilation time in the ICU, length of ICU stay, and LOS in the hospital.
Observational management of Grade II or higher blunt traumatic thoracic aortic injury
Authors: Ye Jin Bong , Lee Jin Young , Lee Jin Suk , Kim Se Heon , Choi Hanlim , Kim Yook , Yoon Soo Young , Sul Young Hoon , Choi Jung Hee
Published: June 2022

Background:

We aimed to investigate the outcomes after delayed management of ≥ Grade II blunt traumatic thoracic aortic injury (BTAI).

Methods:

Between January 2005 and December 2019, we retrospectively reviewed the medical records of 21 patients with ≥ Grade II thoracic aortic injury resulting from blunt trauma. Twelve patients underwent observation for the injury, whereas nine patients were transferred immediately after the diagnosis. Patients were divided into a nonoperative management group (n = 7) and delayed repair group (n = 5) based on whether they underwent thoracic endovascular aneurysm repair or surgery.

Results:

The most common dissection type was DeBakey classification IIIa (n = 9). Five patients underwent delayed surgery (including aneurysm repair), with observation periods ranging from 1 day to 36 months. The delayed repair group exhibited higher injury severity scores than the nonoperative management group (n = 7). The nonoperative management group was followed-up with blood pressure management without a change in status for a period ranging from 3 to 96 months.

Conclusions:

Our findings indicated that conservative management may be appropriate for select patients with Grade II/III BTAI, especially those exhibiting hemodynamic stability with anti-impulse therapy and minimally sized pseudoaneurysms. However, further studies are required to identify the risk factors for injury progression and long-term outcomes.
Approach to new-onset facial nerve palsy in a critically ill patient
Authors: Misra Saumitra , Kumar Saurabh , Rai Nitin , Saran Sai
Published: June 2022

Lower motor type of facial nerve palsy (Bell's palsy) is one of the most common types of facial nerve palsy, with well-defined management with steroids and antivirals for patients attending outpatient clinics. The diagnosis and management of facial nerve palsy in critically ill patients require an individualized approach, as there may be many other causes like soft-tissue compression due to facial edema which can occur as a complication of prone ventilation and severe subcutaneous emphysema. This report highlights the challenges in the management of new-onset facial nerve palsy diagnosed in the intensive care unit (ICU) for a patient on mechanical ventilation, and creates a necessity for a standard operating protocol for the management of such scenarios in ICU.
Diagnostic Accuracy of Coronary Artery Calcium Score for Excluding Obstructive Coronary Artery Disease
Authors: Bansal Manish , Sharma Deepak , Kasliwal Ravi R.
Published: June 2022

Background:

Studies in western populations have shown that zero coronary artery calcium score (CACS) is associated with a very low prevalence of obstructive coronary artery disease (CAD), even in patients presenting with chest pain. However, no data are available about the relationship between CACS and coronary artery plaques among Indian subjects.

Methods:

A total of 380 subjects undergoing comprehensive health check, including computed tomography coronary angiography (CTCA), at a tertiary care center in North India were included. The distribution of CACS was correlated with the coronary plaque burden and with the clinical and laboratory investigation findings.

Results:

The mean age of the subjects was 52.8 ± 10.0 years, and 71.8% were men. The median CACS value in the study population was 0 (interquartile range 0–4.3). Two-third of all the subjects had zero CACS and 91 (23.9%) had CACS between 1 and 99. Nonobstructive and obstructive (>50% stenosis) plaques were found in 106 (27.9%) and 24 (6.3%) subjects, respectively. Only 5.9% of the subjects with zero CACS had any coronary plaque and only 1.2% had obstructive plaques, yielding zero CACS 98.8% negative predictive value for excluding obstructive disease.

Conclusion:

This study shows that similar to the western populations, in Indian subjects also, zero CACS is associated with a very low prevalence of obstructive CAD and has excellent negative predictive value for ruling it out. Further large studies in diverse patient subgroups, including those with stable or unstable chest pain, are required to validate these findings.
Etiology of a Rare Intraglandular Foreign Body in the Parotid Gland
Authors: Oz Cem , Kapi Emin , Erkan Sanem Okgan , KüLahçi Özgür
Published: June 2022

Foreign bodies observed in the parotid gland generally origins from trauma. These foreign bodies are commonly solid structures such as metal, stone, and glass, but foreign body compatible with plant histomorphology is a rare condition. In this study, we present the diagnosis and treatment methods that we applied to this clinical entity, which is very rare in the literature. A 44-year-old female patient who applied to our clinic with a mass on her left cheek that developed in the past 3 months was evaluated. The patient underwent foreign body excision from the parotid gland. On the patient who had a stricture in the Stensen duct during intraoperative exploration, the duct was dilated, and the patient was followed up. Foreign body with vegetative morphology, which settles into the parotid gland by retrograde migration, is a very rare condition. The importance of being aware of possible complications, and a meticulous surgical approach should also be taken into consideration.
Evaluation of Hand Injuries Admitted to Emergency Department of a Tertiary Care Center
Authors: Oner Mehmet Besir , Yalcin Can Ege , Baghaki Semih , Demiröz Anil , Ikizceli Ibrahim , Çetinkale Oguz
Published: June 2022

Background:

In this study, we aimed to evaluate the characteristics of patients who were admitted to the emergency department for a hand injury and to make preventive inferences for hand injuries in terms of public health.

Materials and Methods:

We conducted a retrospective analysis of 10,352 patients admitted to the emergency department between August 2016 and July 2020.

Results:

The average age was 28.4. Injuries mostly occurred in the 25–34 age interval (18.7%). Men predominated in the patient group (70.27%), and injuries were almost equally distributed between right and left sides, with fingers being the most frequently affected region. Common etiologies included falling, occupational injury, and home accidents, leading most frequently to fracture/dislocations, skin-nail injuries, and tendon injuries. Amputations comprised 6.3% of the injuries. Complicated injuries mostly occurred in young males and were mostly due to work accidents.

Conclusions:

Hand injuries can be devastating, and increased individual and social awareness and improved occupational standards are required for prevention (level of evidence: III).
Convalescent Plasma in Older Adults with COVID-19: A Systematic Review and Meta-Analysis
Authors: Aryana I Gusti Putu Suka , Daniella Dian , Paulus Ivana Beatrice , Rini Sandra Surya , Setiati Siti
Published: June 2022

Background: Among all patients infected with coronavirus disease 2019 (COVID-19), the older adult population was the most affected, with 80%–90% of fatalities occurring in this group. The effectiveness of convalescent plasma (CP) in older adults is considerably more restricted than that in adults, resulting in a demand for data on the efficacy of therapeutic CP in older adults. This meta-analysis of updated literature examined the effect of CP in older adults with COVID-19.Methods: Relevant literature was identified from studies indexed in the Cochrane, PubMed, and Google Scholar databases between December 2019 and April 2022. The primary outcome was all-cause mortality. Risk estimates were pooled using a random-effects model. The risk of bias was assessed by regression-based Egger test using the relative risk (RR) and upper and lower confidence intervals (CIs) of the three included studies.Results: Among 377 studies identified, three full-text studies that included 1,038 patients met the inclusion criteria. The results of our meta-analysis showed that CP administration lowered the mortality risk in older adults with COVID-19 (RR=0.47; 95% CI, 0.26–0.86; p=0.01; I2=0%, p<0.81). CP therapy was more useful if delivered early in the course of the disease (within 72 hours of onset) and in less severe stages of the disease. Mortality tended to be lower in the high-titer group.Conclusions: CP treatment was significantly associated with a lower risk of mortality in older adults with COVID-19 than in patients not administered CP. The timing of CP administration is critical since earlier treatment after disease onset was associated with a better prognosis.
‘Metastatic seed’ of cholera in Edo State, Nigeria: a case report
Authors: Adewuyi G.M. , Samuel O.S. , Unuane A.E. , Iraoyah K.O. , Onuha G.O. , Otumu O.T. , Ogbue J.I.
Published: June 2022

There were reported cholera epidemics in some States in Nigeria. Cholera is an acute diarrhea disease with marked epidemic propensity, caused by  colonization of the small intestine by Vibrio cholerae serogroup 01 or 0139. Cholera, like other infectious diseases epidemics, has propensity for  sending metastatic seed to any susceptible remote community. If the metastatic seed can be promptly diagnosed and managed appropriately, the  spread and development of new epicenter can be aborted. This report is a case of metastatic cholera who presented in a tertiary hospital in Edo  State, Nigeria. The case was promptly detected and effectively managed using good surveillance system, inter-departmental collaboration, swift  responses, good laboratory practices, patient isolation and infection prevention and control measures, coupled with appropriate fluid and  antimicrobial treatments. This prevented cholera epidemic in the hospital and Edo State in general.
Overview of human and animal brucellosis in Nigeria and its economic impacts on production
Authors: Ukwueze C. S , Kalu E. , Odirichukwu E.O. , Ikpegbu E. , Luka P.D.
Published: June 2022

Brucellosis is a wide spread zoonotic bacterial disease of humans and animals. In humans the disease is recognized commonly as undulant fever, characterized by headache malaise, and arthritis. Brucellosis can occur in any age group, but mainly found in young men between the ages of 20 and 40 years because of occupational hazards. Domestic animals (cattle, sheep and goat, pigs, dogs etc) are highly susceptible to brucellosis.  Generally, brucellosis manifest in female animals as abortion, retained placenta, stillbirth and death of young ones soon after birth. In males, the  main features are vesiculitis, orchitis, and epididymitis, which may render infected male infertile for life. The endemicity of brucellosis has remained  a threat in low- income countries of sub-Saharan Africa and South Asia and has multiple economic implications across agriculture and public health  sectors, and broader implications on economic and social development sectors. Google and Google Scholar were used to retrieve articles used for  this review, which included published research articles and local, national and international reports on brucellosis. In this review, we summarised  human and animal brucellosis, prevalence of infections in Nigeria, and economic impacts on production. It is believed that this review will guide  researchers on the state of brucellosis in developing countries where the disease is still endemic, using Nigeria as a case study.
Exploration of Aqueous Phyllanthus amarus Leaf Extract as a Protective Agent in Mercury Chloride-Exposed Wistar Rats: A Neurobehavioural Study
Authors: Enogieru A. B. , Omoruyi S. I.
Published: June 2022

Mercury (Hg) exposure is known to damage vital components of the central nervous system primarily through oxidative stress. Although Phyllanthus amarus (PA) is reported to be rich in antioxidants, there is a dearth of relevant research evidence to show its protective activity against Mercuric chloride (HgCl2)-induced neurotoxicity. Accordingly, this study was designed to investigate the possible protective activity of aqueous Phyllanthus amarus leaf extract (APALE) in HgCl2-exposed rats using standard neurobehavioral assessments. Thirty adult Wistar rats were randomized into six groups of five rats each viz: A: Control, distilled water; B: HgCl2 (4 mg/kg body wt.); C: APALE (200 mg/kg body wt.) + HgCl2 (4 mg/kg); D: APALE (400 mg/kg body wt.) + HgCl2 (4 mg/kg); E: APALE (200 mg/kg body wt.); F: APALE (400 mg/kg body wt.). All administrations were through an orogastric tube for 14 days. Thereafter, neurobehavioral tests (open field, novel object and Y-maze) were done and experimental rats were sacrificed by cervical dislocation. Body, brain and cerebellar weights were examined across all groups. HgCl2 exposure significantly (p<0.0.05) decreased whole body weight across experimental groups. Similarly, a reduction in brain and cerebellar weight was observed. Significant neurobehavioral alterations to locomotion, discrimination index and cognition/memory, induced by HgCl2, were observed across experimental groups. However, protection against the deleterious effects induced by HgCl2 was observed following pretreatment with APALE. Conclusively, these findings show that APALE demonstrated potent protective activity against HgCl2-induced neurotoxicity and may be useful in the management of Hg toxicity and other related disorders.
Effect of Coarse Aggregate Size and Gradation on Workability and Compressive Strength of Plain Concrete
Authors: Mkpaidem N. U. , Ambrose E. E. , Olutoge F. A. , Afangideh C. B.
Published: June 2022

In this study effect of coarse aggregate size and gradation on workability and compressive strength of concrete was investigated. A mix ratio of 1:2:4 with a target strength of 20/25MPa, was adopted with a water-cement ratio of 0.6. Concrete cubes were produced with uniform coarse aggregate size of 4.75, 6.7, 9.5, 13.2 and 19mm respectively, with another set of samples produced with all the coarse aggregate sizes. Slump tests were carried out for all mixes and all sets of samples were tested for compressive strength after, 7, 14 and 28 days of curing. It was observed that workability was similar for all mixes with no well-defined pattern of relationship with size of coarse aggregate used. Compressive strength was observed to increase with increase in coarse aggregate size. Authors attributed this to the less quantity of water absorbed by larger size coarse aggregate during mixing which results in lesser quantity of capillary pores after curing. Maximum compressive strength was recorded for samples with 9.5mm coarse aggregate size. These show that quality concrete can still be produced with single-sized coarse aggregate as long as the optimum size can be determined for the particular mix.
Bioactive Compounds and Mineral Contents of Telfairia occidentalis hooker fil. Grown in Urea Solutions
Authors: Agogbua J. U. , Akonye L. A. , Mensah S. I. , Okonwu K.
Published: June 2022

The study focused on the use of Urea containing hydroponic solutions for growing Telfairia occidentalis Hooker fil and evaluated the bioactive compounds and mineral contents of T. occidentalis. They solutions varied in the amount of Urea granules (25g, 50g, 75g, 100g, 125g and 150g, respectively) dissolved in water and designated as M25U, M50U, M75U, M100U, M125U, M150U and Control, respectively. Two-week old seedlings of T. occidentalis raised using River-sand were transferred into the growth media; in four replicates. The bioactive compounds (nutritional composition, vitamins, and amino acids contents) and mineral content were determined 5 weeks after planting following standard procedures. Telfairia occidentalis grown in Control and M25U media had the highest energy level (1509.76 KJ/100g and 1496.70 KJ/100g, respectively) while the lowest energy content (1351.87 J/100g) was recorded at M75U growth medium. The study showed that T. occidentalis contains more of water-soluble vitamins than fat-soluble vitamins. The leaves grown in M100U medium had the highest total vitamins value. Also, 9 essential amino acids (EAA) and 11 non-essential amino acids (NEAA) were detected and quantified in the leaves of T. occidentalis grown in varying Urea solutions. The EAA contents were lower than the NEAA contents. Amongst the amino acids and growth media, glycine content (9.10%) of leaves was the most concentrated in M50U medium. The concentrations of N, Ca, Mg and K in the leaves were high compared Na, Mn, Fe, Zn and Cu in the growth media. The leaves grown in the Control medium had the lowest mineral content in most of the growth media.
UYGUR HALK MASALLARINDA HIZIR MOTİFİ
Authors: Erk Zohre Abduvahit
Published: June 2022

Yüzyıllardır Türk kültürünün önemli bir parçası olarak bilinen Uygurların, halk bilimi alanına önemli katkılarda bulunmuş olduğu bilinir. Uygurların zengin anlatma kültürü, yılların birikimiyle ortaya çıkan Türk kültürünün bir parçasıdır. Tarihten bu yana sözlü gelenek içerisinde gelişip kuşaktan kuşağa aktarılarak ve zenginleşerek günümüze ulaşan masallar hem yerel hem de evrensel ögeler taşıyan anlatılardır. Toplumun zengin kültürü masallardaki en küçük öğe olan motifler aracılığıyla bizlere aktarılır. Masallarda karşımıza çıkan ana motiflerden biri de Hızır motifidir.
Hızır, Türk kavimlerinde en yaygın olan ve halk edebiyatında sık sık karşımıza çıkan karekterdir. Uygurlar arasında diğer Türk kavimlerinde olduğu gibi Hızır ile ilgili birçok inanış vardır. Işbu inanış ve anlayışların bazıları İslamiyetten önceki anlatılara kadar uzandığı bilinmektedir.
Bu çalışmanın amacı Uygur masallarındaki Hızır motifini örnekleriyle birllikte ele almak; ecdadımızın kadim kültürünün hızır motifleri üzerinde bıraktığı etkilerini ve izlerini irdelemektir. Yayının Türk kavimlerinin ortak değerlerinden olan Hızır motifi ile ilgili karşılaştırmalı incelemelere katkı sağlaması temenni edilir.
TOPSIS VE AHP ÇOK KRİTERLİ KARAR VERME YÖNTEMLERİNİN PERSONEL SEÇİM SÜRECİNE UYGULANMASI
Authors: ADA Mehmet , ÇAKIR Hüseyin
Published: June 2022

İşletmelerde yönetim faaliyetinin temelini karar verme ve problem çözme süreci oluşturmaktadır. İlkel zamanlardan, günümüze kadar bireyler çeşitli durumlarda karar verme problemiyle karşı karşıya kalmışlardır. Karar verme, alternatifler arasından seçim yapma işidir. Geleneksel kararlarda, karar süreci ile ilgili veriler toplanır ve analiz edilerek sonuç değerlendirmeye gidilir. Ancak günlük hayatta insanların karşılaştıkları durumlar veya sorunlar ile ilgili kararlar genellikle birden fazla ve kendi içinde çelişen kriterlere sahiptir. Bu durum göz önüne alındığında, karara ulaşmak için sezgisel yöntemler kullanılması yetersiz kalmaktadır. Çok yönlü karar verme problemleri hayatın her alanında işletmeler ve/veya organizasyonların karşısına çıkmaktadır. Karar vericiler çoğunlukla birden fazla faktörün ve farklı ölçeklenebilirliğe sahip kriterlerin bulunduğu durumlarda karar vermektedir. Çok Kriterli Karar Verme (ÇKKV), karar vericinin sonlu ve sayılabilir yahut sayılamaz sayıda alternatiften oluşan bir küme içinde minimum iki kriter kullanarak yapmış olduğu seçim işlemi olarak tanımlanabilir. Özellikle stratejik seviyede bulunan yöneticilerin karşılaştığı karmaşık karar problemlerde en uygun kararı vermesi için Çok Kriterli Karar Verme süreçlerini işletmesi kolaylıklar sağlayacaktır. Çok kriterli karar verme teknikleri, farklı ölçeklenebilirliğe sahip birden fazla kriter kullanılarak “en uygun” çözüme ulaşmayı hedefleyen yöntemlerden oluşur. Bu çalışmada, iki farklı ÇKKV süreci birlikte işletilerek yöneticinin karar verme ihtiyacını karşılayan bir Karar Destek Sistemi önerilmektedir. Bu kapsamda, AHP (Analytic Hierarcy Process) ve TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) ÇKKV yöntemleri birlikte kullanılmıştır. Seçim kriterlerinin ağırlıklarının belirlenmesi için AHP yöntemi, belirlenen kriterler ışığında adayların sıralanması için TOPSIS yöntemi kullanılmıştır. Bahsi geçen her iki ÇKKV yöntemi de “Kıyaslanamazlığın dışlandığı tek ölçütlü sentez yaklaşımı” olarak nitelendirilmektedir.
ENVENENAMENTO POR ESCORPIÃO CAUSANDO PANCREATITE AGUDA EM CRIANÇA
Authors: Almeida Rabelo Rosário Claudialine , Ramos Souza Lucas , Alves Afonso Ruas Maicon , Fernando Guimarães de Carvalho Sílvio , Amaral Carvalho Adriana
Published: June 2022

Objetivo: relatar o primeiro caso ocorrido no Hospital Universitário Clemente de Farias em Montes Claros de uma complicação gastrointestinal rara do escorpionismo em criança: a pancreatite aguda edematosa. Método: as informações foram obtidas por meio de revisão do prontuário médico, registro fotográfico do exame de imagem e revisão atualizada da literatura. Resultado: a paciente evoluiu com sintomas gastrointestinais persistentes associada à achados laboratoriais de leucocitose, hiperglicemia e elevação expressiva das enzimas pancreáticas, além de ultrassonografia e tomografia de abdome compatíveis com pancreatite aguda. No quinto dia de internação hospitalar, apresentou resolução espontânea do quadro com medidas de suporte clínico. Considerações finais: É essencial evocar o diagnóstico de pancreatite aguda no contexto de dor abdominal em escorpionismo para tratamento precoce e melhor desfecho clínico do paciente.
Cloud-based thermal simulation of brake disc cooling performance
Authors:   ICON, Taucher Christian
Published: June 2022

"To automate and make simulation set-up easy and simple ICON has set up a cloud-based platform. This platform allows the user to set up, run and manage multiple design iterations to find the optimum solution. For this an App has been developed for efficient thermal CFD simulation of the brake disc cooling flows including its thermal effects, especially the prediction of the heat transfer coefficients. This allows analysis of the thermal performance of different cooling designs in short timeframes and increases the accuracy of thermal prediction to optimize the design’s cooling potential at a minimum dimension of the disc. Once a design has been defined, ICON’s novel BAF boundary conditions can be applied with advanced thermal models to integrate into a full vehicle model, to further refine the design in the final environment. This boundary condition allows to model the thermal distribution of the disc heat fluxes, while rotating this on a static CFD mesh. This helps to keep the run time of a simulation small while the accuracy remains high and thus makes it possible to run more design optimizations in the same timeframe. Moreover, using conjugate heat transfer not only the disc itself, can be assessed, but furthermore the domain can be expanded to predict the temperatures for example of the calliper, brake fluid, pistons or any heat shields surrounding the disc. The simulation model considers heat conduction, convection as well as radiation. With the help of ICON’s advanced tools, the set-up of this complex thermal simulation can be made simple and enables simulating minutes of real time disc heat up and cool down cycles on a full vehicle simulation in a matter of hours. To demonstrate these methods on a non-confidential geometry, ICON has used the AeroSUV model provided by ECARA and modified it to include a realistic brake cooling system and front corner geometry. "
Wet grip braking performance on worn tyres
Authors:   Applus IDIADA, Anadon Ricard , Cruz Carmelo ,   Applus IDIADA
Published: June 2022

"Regulatory performance parameters are always measured on new state tyres. Most of performance parameters are not showing relevant deterioration overtime, however, it is proven that Wet Grip performance is deteriorating progressively as the tyre worn out during its life. Wet grip performance deterioration means vehicle longer stopping distance on wet condition. It was also found that the wet grip index on worn tyres could not be predicted from the wet grip index on new condition tyres, at least on C1 tyres. No correlation was found. As this is a safety issue, Regulatory authorities and major stakeholders agreed to develop new test method and thresholds for wet grip on worn tyres. Basic test protocols described in UN R117.02 are observed, however, there are many specific topics that need to be addressed, such as, how to obtain artificially worn tyres fully representative of natural worn tyres, the use of reference test tyres in worn or new condition, new limits, among others. This presentation is a summary of the conclusions so far and the proposal for new Regulatory requirements is proven that Wet Grip performance is deteriorating progressively as the tyre worn out during its life. Regulatory authorities and major stakeholders agreed to develop new test method and thresholds for wet grip on worn tyres. "
Adsorption of copper (II) ions by using low cost activated carbon from aqueous solution
Authors: T Vimalarani  , Venkatraman B.R
Published: June 2022

In the present study, adsorption of copper (II) ions from aqueous solution by activated Kigelia africana rind nano carbon (KANC) was investigated under batch mode. The influence of solution pH, sorbent dose, copper (II) ions concentration, contact time, and temperature was studied. The copper (II) ions adsorption was favored with maximum adsorption at pH 6.5. Sorption equilibrium time was observed in 60 min. The equilibrium adsorption data were correlated with Langmuir and Freundlich isotherm models. The kinetics of the adsorption process was tested by pseudo-second order, Elovich and intraparticle diffusion models. It was shown that adsorption of copper (II) ions could be described by the pseudo-second order kinetic model. Thermodynamic parameters such as Gibbs free energy (ΔG0), the enthalpy (ΔH0) and the entropy change of sorption (ΔS0) have also been evaluated and it has been found that the adsorption process was spontaneous, feasible, and exothermic in nature. The results indicated that activated KANC can be used as an effective and low-cost adsorbent to remove Cu (II) ions from aqueous solution.
Analysis of water quality using physico-chemical parameters for water samples from Kanyakumari district, India
Authors: Ajantha Aekis T  , Indirani B
Published: June 2022

This Paper deals with the Physico - chemical Parameters for five water samples from Kanyakumari District, Tamil Nadu. Monthly Changes in Physical and Chemical Parameters Such as Water Taste, Turbidity, Total Dissolved Solids, pH, Total hardness, Conductivity for a period of one year from October2014 to September2015. All Parameters were within the permissible limits. The results indicate that the water in the five stations are Non-polluted and can be used for Domestic, Irrigation and Fisheries.
MANIPULATIVE NATURE OF MEDIA-POLITICAL DISCOURSE
Authors: Gasparyan Seda , Harutyunyan Rafayel
Published: June 2022

At the present moment, media saturation provides us with a reasonably objective criterion available for examination.  In a loose sense, the Internet has become a parallel reality where people live to pursue constantly updated news at the repeated click of a button, which maintains the reader's immediate interest in every sense of the word.  In perusing news articles, placing a particular emphasis on their manipulative nature, we can plunge deeply into such language layers as that of the lexical, grammatical, stylistic, etc.  In this paper we place our central interest on the lexical aspect of language manipulation because words are the foundation of meaning in speech.  A functional-communicative view of the lexical material of the discourse of news articles reveals the effect of a journalist's choice and arrangement of words on the reported news and how the manipulative potential of language unfolds.