bluuebunny/crossref_metadata_2025 huggingface dataset:
Microbiological evaluation of women with vulvovaginitis and cervicitis
Authors: Moro Dauphin , Ali Geraldine
Published: November 2020

INTRODUCTON: The vaginal ecosystem is a complex environment that consists of interrelationships among endogenous microflora, their metabolic products, the host’s metabolic products, oestrogen and the pH level. The endocervix however is a sterile environment, which remains susceptible to many infections. AIM: An investigation of cervico-vaginal infections amongst female patients aged 14-63 years attending two private hospitals in Lagos, Nigeria was carried out. METHODS: A total of 480 female patients constituting 444 with and 36 without vaginal discharge were examined. Both high vaginal (HVS) and endocervical swab (ECS) were taken from these patients and subjected to microbiological examinations. Antibiotics susceptibility pattern was determined using the disc diffusion technique. RESULTS: Eight different 8 species of microorganisms were isolated. The most predominant was Gardnerella vaginalis, which accounted for 264 (49%) of the total isolates, followed by Candida albicans, 120 (22%), Escherichia coli, 76(14%) Trichomonas vaginals, 28(5%) and Neisseria gonorrhoeae , 32(6%). Other were Proteus mirabilis, 8(1.5%) and Streptococcus pyogenes 4(0.7%). Mixed infections were observed in 20% of the patients studied. CONCLUSION: The health implication of the organisms isolated especially the high incidence of Gardnerella vaginosis in women of reproductive age can predispose them to sexually transmitted diseases (STDs), spontaneous abortion, pre-term delivery among others. The bacterial isolates were most sensitive to Gentamycin, Pefloxacine and Ceftriaxone, while most of them were resistant to Ampicillin and Tetracycline which are commonly available and abused over-the-counter drugs. Keywords: Vulvovaginitis, cervicitis, monogamy, microbial pathogens, endogenous microflora.
EFFECT OF ETHANOLIC EXTRACT OF MOMORDICA CHARANTIA ON ANTIOXIDANT AND INFLAMMATORY MARKERS IN MALE BALB/c MICE ADMINISTERED ACYCOR-PLUS
Authors: Ogungbe Bimpe
Published: November 2020

Introduction: Acycor-plus (ACY) is a single dose combined analgesic and anti-inflammatory drug. Prolonged usage and overdose often lead to gastro-intestinal ulcerations, inflammations and oxidative stress which increases the use of synthetic H2 antagonists such as cimetidine (CMT). Aims: This study was carried out to monitor the antioxidant and inflammatory effects of ethanolic extract of Momordica charantia (MC) in ACY-administered male Balb/c mice. Materials and Methods: Twenty-five mice weighing between 15-20g were equally divided into five groups and received normal saline (Control), 2.5mg/kg ACY alone (ACY), ACY combined with either 50mg/kg cimetidine (CMT) or 100mg/kg and 200mg/kg ethanolic extract of Momordica charantia (MC100 and MC200, respectively). The animals were sacrificed after three days by cervical dislocation and post-mitochondrial fractions of their livers, kidneys, small intestines and colons were used to assess the activities of antioxidant and inflammatory markers. Results: MC100 and MC200 significantly reduced antioxidant markers except catalase (CAT) when compared with ACY while they increased hepatic myeloperoxidase (MPO) and nitric oxide (NO) (p<0.05). Kidney and colonic MPO activities were significantly reduced by MC100. However, MC200 significantly increased renal CAT, superoxide dismutase (SOD) and SOD/(GPx+CAT) ratio with increased oxidative stress. Conclusion: It can be concluded that MC100 had comparable effect with CMT while MC200 might induce renal toxicity. However, further research is needed using other routes of administration.
Atypicity of Vibrio cholerae  O1 strains based on agglutability
Authors: Levchenko Darya A. , Arhangelskaya Irina V. , Kruglikov Vladimir D. , Podoinitsina Oksana A.
Published: November 2020

The review analyzes literature data on the phenotypic variability of Vibrio cholerae of the O1 serogroup. Three types of polysaccharide structures are distinguished in the cholera pathogen: lipopolysaccharide, or O-antigen, capsular polysaccharide and exopolysaccharide. The rugous form of V. cholerae strains is able to synthesize exopolysaccharide which is highly resistant to antimicrobials, and to form wrinkled colonies that can be agglutinated with cholera sera in various combinations. Serological classification of V. cholerae is based on the specificity of the lipopolysaccharide. V. cholerae of serogroups O1 and O139 causes cholera epidemics, although strains from non-O1/non-O139 serogroups with the main virulence factors are known. Upon transition from the Sto the R-form, lipopolysaccharide loses the O-polysaccharide, and the central region begins to fulfill the function of somatic antigen, exhibiting R-specificity. The serological differences in the strains of V. cholerae are based on a change in the regulation or structural organization of genes encoding the biosynthesis of O-antigen (rfb). From 1988 to 2019, 168 strains of V. cholerae that are atypical for agglutinability and were isolated from the R variant were isolated from environmental objects in the territory of the former USSR and subjects of the Russian Federation; the genetic organization of these strains has not been fully studied. The evolutionary relationships of atypical strains of cholera vibrios isolated from environmental objects in Siberia and the Far East are determined on the basis of a comparative analysis of housekeeping genes. The analysis of the results of basic and applied research indicates that the problem of variability in agglutinability of V. cholerae strains isolated from humans and from environmental objects remains relevant at the current stage of development of the seventh cholera pandemic. The atypicality of strains of V. cholerae O1 on this basis is considered in aspects of the environmental conditions of their existence and the conditionality of phenotypic manifestations by molecular biological determination.
SARS, SARS again, and MERS. Review of animal models of human respiratory syndromes caused by coronavirus infections
Authors: Nagornykh Aleksey M. , Tyumentsev Alexander I. , Tyumentseva Marina A. , Akimkin Vasily G.
Published: November 2020

Since the beginning of the 21th century, major outbreaks of human respiratory syndromes caused by coronavirus infections have caused more than million deaths on the planet. Despite the fact that the first wave of the coronavirus infection took place back in 2002, even now there is not any adequate animal model that would meet the needs of the scientific community for reproducing the pathogenesis, clinical manifestations, immunogenicity, development and testing of preventive and therapeutic compounds specific to Severe Acute Respiratory Syndrome, Middle East Respiratory Syndrome, and Coronavirus Disease 2019 (COVID-19).The purpose of the study is to provide relevant information on known animal models of human respiratory syndromes caused by coronavirus infections and to focus the reader's attention on their adequacy, which consists in the most accurate imitation of clinical signs and pathomorphological changes.
Neutrophil extracellular traps in the fight against biofilm-forming microorganisms: hunters or prey?
Authors: Dolgushin Ilya I. , Mezentseva Elena A.
Published: November 2020

The review presents up-to-date data on the relationships between neutrophil extracellular traps (NETs) and biofilm-forming microorganisms P aeruginosa, S. aureus, Candida spp. obtained in vitro and in vivo studies. Up to 80% of human microbial infections are associated with biofilm-forming microorganisms. The formation of highly specialized biofilm communities is one of the main strategies for the survival of bacteria and fungi, significantly increasing their tolerance to aggressive and stressful environmental conditions, chemotherapeutic drugs, and immune system factors, contributing to their persistence and chronicity of the infectious process. The formation of NETs in the process of NETosis is one of the biological mechanisms used by neutrophils in protection against pathogens. Chemoattractants of biofilm origin, as well as those secreted by epithelial and immunocompetent cells, attract and activate migrating neutrophils. However, given that bacteria form fairly large cell clusters and aggregates in biofilms, the process of phagocytosis is sometimes difficult or impossible. Under these conditions, it is logical to assume that the importance of NETs in anti-biofilm immunity increases. However, due to the components of the extracellular biofilm matrix (e.g., Psl exopolysaccharide P aeruginosa), quorum sensing (QS) molecules (e.g., LasR QS system P aeruginosa), enzymes (e.g., LasA protease and LasB elastase P. aeruginosa), toxins (e.g., Panton-Valentine leukocidin and AB Y-hemolysin S. aureus) and probably other factors yet to be studied, the microorganisms in biofilms are able to influence the signaling systems involved in NETosis, the intensity of the formation of NETs, the sequestration and killing mechanisms in them, sometimes subordinating and using NETs components for their own purposes.
La Orientación del ordenamiento italiano en materia de prevención de la corrupción
Authors: Gallone Giovanni
Published: November 2020

La lucha contra la corrupción es uno de los temas más críticos de la administración italiana. Tradicionalmente se ha preferido un enfoque represivo, que se ha centrado en el endurecimiento de las sanciones penales. Sólo recientemente, sobre la base de las experiencias jurídicas de otros países, se ha producido un cambio hacia la prevención. Desde este punto de vista, la corrupción es un riesgo endógeno para la Administración que debe ser abordado a través de la planificación de medidas organizativas. Aunque se han logrado buenos resultados, los puntos de especial sensibilidad susceptibles de mejora siguen siendo numerosos.
La Gobernanza Pública y la Perspectiva Clásico-Liberal
Authors: Calvo López Santiago
Published: November 2020

Recensión de Paul Dragos Aligica, Peter J. Boettke y Vlad Tarko: Gobernanza pública y perspectiva clásica-liberal: fundamentos de economía política. Oxford University Press, Nueva York, 2019, 267 páginas.
Stress state of anvils of continuous casting and deformation installation during production of steel-copper three-layer bimetallic strips
Authors: Lekhov O.S. , Shevelev M.M.
Published: November 2020

The main loads acting on the anvils of installation of the combined process of continuous casting and deformation during the production of steelcopper three-layer bimetallic strips are described. The method for determining of the temperature and thermoelastic stresses in anvils of installation using the ANSYS package is presented.
The boundary conditions for determining of the temperature fi elds in anvils of the installation during the production of copper—steel—copper bimetal is described. The regularities of the distribution in anvils of temperature
and thermoelastic stresses during reduction of steelcopper bimetallic ingot and at idle are presented. The values
and regularities in the distribution of total stresses from the reduction force and thermal loads when producing
steelcopper three-layer bimetallic strips on installation of the combined process of continuous casting and deformation are given.
Improving in mandrelling efficiency of spline holes under infl uence of ultrasonic field
Authors: Berberov S.A. , Lebedev V.A. , Kochetov A.N. , Torop Yu.A.
Published: November 2020

The analysis of the technological parameters of the finishing and strengthening of spline holes by shaped mandrels is performed. It is shown that the main technological parameter determining the processing efficiency is pull.
Technological scheme for the mandrelling of spline holes of gear wheels is proposed, which ensures its reduction
by applying ultrasonic field to the workpiece.
Technological scheme
of fi nishing and strengthening of parts in screw working elements machines and rationale for their drive power
Authors: Chaava M.M. , Serga G.V. , Al Obaydi Luai Mohammed Rajab
Published: November 2020

Typical technological scheme of the machine for finishing and cleaning and strengthening treatment with working
elements in the form of screw rotors mounted from tetrahedral voids is presented. Method for calculating of the drive
of these machines is proposed, taking into account the load mass, the working element mass and the load mass located
asymmetrically in the working element of the rotation axis, which allows you to calculate the power of the electric motors of machines for finishing, cleaning and strengthening treatment taking into account the actions of symmetrical and
asymmetric loading processed parts and particles of the working medium relative to the rotation axis of the screw rotor.
HUBUNGAN KEPUASAN TERAPI DENGAN KUALITAS HIDUP PASIEN DIABETES MELLITUS TIPE-2 DI PELAYANAN PRIMER (PUSKESMAS JETIS 1 BANTUL)
Authors: Akrom  , Muhammad Muhlis  , Yenny Sri Wahyuni
Published: November 2020

Diabetes adalah penyakit kronis serius yang terjadi karena pankreas tidak menghasilkan cukup insulin (hormon yang mengatur gula darah atau glukosa), atau ketika tubuh tidak dapat secara efektif menggunakan insulin yang dihasilkannya. Melitus merupakan sindrom metabolis kronis yang menjadi salah satu penyebab kematian terbesar di dunia. Desain Penelitian ini adalah penelitian jenis Observasional, dengan menggunakan pendekatan cross sectional, dimana subyek penelitian hanya diobservasi. Penelitian ini mengambil subyek sebanyak 109 pasien. Pengambilan data secara prosepektif dan dilakukan dengan cara mengumpulkan informasi dari pasien melalui wawancara tatap muka (face-to-face interview) menggunakan kuesioner. Kuesioner yang digunakan pada penelitian ini berjumlah dua kuesioner yaitu, data demografi pasien, kuesioner kepuasan (TSQM), kuesioner Kualitas Hidup (EQ5D).

          Analisis data  menggunakan Uji Statistik dengan bantuan SPSS versi 23. Data sosio-demografi pasien meliputi jenis kelamin, usia, pernikahan, pekerjaan, pendidikan dan penyakit penyerta pasien pendeita DM type 2 disajiakan dalam tabel distribusi frekuensi. Uji Chi Squaredilakukan untuk mengetahui hubungan antara sosio-demografi dengan kepuasan terapi dan hubungan sosio-demografi dengan kualitas hidup.

          Hasil hitung dengan bantuan SPSS versi 23 menunjukkan bahwa nilai p value >0,05 sehingga dapat disimpulkan bahwa tidak ada hubungan antara sosio-demografi dengan kepuasan terapi dan tidak ada hubungan antara sosio-demografi dengan kualitas hidup. Hubungan antara kepuasan terapi dengan kualitas hidup dilakukan uji korelasi Spearman’s rho. Hasilnya diperoleh nilai p value (0,006) < 0,05. dengan demikian dapat disimpukan bahwa terdapat hubungan antara kepuasan terapi dengan kualitas hidup pasien penderita DM type-2.

 

Kata Kunci: Diabetes melitus tipe 2, Kepuasan Terapi dan Kualitas Hidup
Analisa Kualitas Hidup Pembalap Motor Road Race Pasca Mengalami Cedera Tulang Di Jawa Barat Menggunakan European Quality Of Life 5 Dimensions (EQ5D) EQ-5D-5L
Authors: Dedy Frianto  , Riska Novrianty
Published: November 2020

Olahraga balap motor khususnya Road Race cukup populer di Indonesia. Olah raga ini merupakan aktivitas yang dapat memberikan manfaat bagi kesehatan fisik maupun mental. Namun, jika tidak diimbangi kesadaran untuk menjaga keselamatan, sehingga mereka sangat rentan mengalami cedera yang dapat mengganggu kesehatan juga dapat mengurangi atlet tersebut untuk berprestasi secara maksimal. Penelitian ini bertujuan mengidentifikasi dan menganalisa bagaimana kualitas hidup para pembalap motor Road Race pasca mengalami cedera tulang dan terapi atau obat apa digunakan oleh para pembalap pasca mengalami cedera tulang tersebut.

Sampel penelitian ini adalah para pembalap yang diketahui telah mengalami cedera atau patah tulang di Jawa Barat. Desain penelitian menggunakan jenis Observasional Cross Sectional di mana pengumpulan data dilakukan dengan pengisian kuesioner secara prospektif pada semua pembalap di Jawa barat. Pengumpulan data dilakukan dengan menyebarkan kuesioner  European Quality Of Life 5 Dimension (EQ5D5L) secara langsung kepada para pembalap pada Event Bupati Cup Seri 1 – Open Road Race 2.

Berdasarkan analisa data yang dilakukan, diperoleh kesimpulan bahwa kualitas hidup para pembalap pasca mengalami cedera tulang memiliki kualitas hidup yang baik karena didapatkan hasil rata-rata dari skala kesehatan terakhirnya yaitu 0,4888, di mana apabila responden memiliki skala kesehatan 1,000 atau lebih dari -0,594, maka responden dinyatakan memiliki kualitas hidup yang baik pasca mengalami cedera tulang.

 

Kata Kunci: Road Race, Pembalap, Cedera tulang, Kualitas hidup, EQ5D5L

 

The purpose of this study is to find out the most optimal formulation and to find out the physical evaluation results of white glutinous rice extract sheet mask preparations. The method of making experimental formulations using CMC Na as viscosity-increasing agent with F1 concentration (0,2%); F2 (0,3%); and F3 (0,4%). The evaluations carried out are organoleptic test, homogeneity test, pH test, viscosity test, preference test and irritation test. The results showed the essence preparation in the form of a thick solution with a characteristic odor and pale white and homogeneous. PH values ​​of F1 preparations (4,92 ± 0,01), F2 (4,95 ± 0,01), and F3 (4,97 ± 0,02). Viscosity F1 (145,47±10,02 cPoise), F2 (180,37±3,63 cPoise), and F3 (194,80± 18,56 cPoise). The preference test with 32 respondents shows that the average preference for essence color is neutral / ordinary, for aroma is like and for essence texture is neutral / ordinary. Irritation testing on 30 volunteers showed the result that the preparation of white glutinous rice sheet mask was safe with the irritation index value obtained 0.004 (no means).

 

Keyword: white glutinous rices, sheet masks, CMC Sodium.
FORMULASI, UJI STABILITAS FISIK DAN KOMPATIBILITAS PRODUK KOSMETIK ANTI-AGING DALAM SEDIAAN SERUM PUDDING
Authors: Farhamzah  , Aeni Indrayati
Published: November 2020

Serum adalah salah satu sediaan kosmetik berbentuk gel yang digunakan untuk produk anti-aging dan bentuk gel dari sediaan bisa dibuat lebih menarik sebagai variasi dari bentuk serum yang sudah ada. Maka dilakukan penelitian formulasi produk anti- aging dengan sediaan berbentuk serum yang mempunyai tekstur seperti Pudding. Formulasi menggunakan bahan baku polimer dengan konsentrasi 5% dengan perbedaan formula pada konsentrasi parfum. Hasil formulasi dilakukan uji sediaan berupa pemeriksaan organoleptik, pH, viskositas, kelembaban, after feel, rasa lengket, rasa panas, rasa gatal, Uji Stabilitas dan Uji Kompabilitas selama 12 minggu. Hasil penelitian menunjukkan bahwa formula yang tidak menggunakan parfum memberikan hasil stabilitas dan kompabilitas yang baik.

 

Kata Kunci : Stabilitas Fisik, Kompatibilitas, Anti-Aging, Serum Pudding

Serum is one of the gel-shaped cosmetic preparations used for anti-aging products and the gel form of the preparation can be made more attractive as a variation of the existing serum form. Then do research on anti-aging product formulations with serum-shaped preparations that have a texture like Pudding. The formulation uses a polymer raw material with a concentration of 5% with different formulas at the Perfume concentration. The results of the formulations were tested in the form of organoleptic tests, pH, viscosity, humidity, after feel, stickiness, burning sensation, itching, Stability Test and Compatibility Test for 12 weeks. The results show that formulas that do not use perfume provide good stability and compatibility results.

 

Keywords: Stability Test, Compatibility Test, Anti-Aging, Pudding Serum
A Rare Case of Anhydrous Ectodermal Dysplasia
Authors: Wadhwani Meenakshi
Published: November 2020

A 9-year-old boy presented with complaints of itching in both eyes. On ocular examination there was dry lusterless conjunctiva rest of the examination of both anterior and posterior segment was within normal limit. On systemic examination, there was an absence of teeth with flattening of the mandible with a peg-shaped incisor with the absence of tooth buds on oral x-ray and dryness of mouth since birth. He was already a diagnosed case of X linked anhydrous ectodermal dysplasia with a similar history of absence of teeth in elder brother but his elder sister was normal. Similar history of absence of teeth and dryness of mouth since birth. (Figures 1a and b) he was started on conservative management in the form of lubricating drops and ointment.
Exploring the Role of Remote Ischemic Preconditioning In Long Term Cognitive Impairment after Global Ischemia-Reperfusion-Induced Vascular Dementia in Mice
Authors: Jaggi Amteshwar Singh
Published: November 2020

Aim: The aim of the present study is to explore the neuroprotective effects of remote ischemic preconditioning in long term cognitive impairment after global cerebral ischemia induced-vascular dementia in mice.

Material and methods: The mice were subjected to global cerebral ischemia by occluding the bilateral common carotid arteries for 12 minutes followed by the 24 hours of the reperfusion. The remote ischemic preconditioning stimulus was delivered in the form of 4 cycles of ischemia/reperfusion for 5 minutes each. The cerebral ischemic injury induced-long term cognitive impairment-related learning and memory alterations was assessed using morris water maze, the motor performances of the animals were evaluated using rota-rod test and neurological severity score. The cerebral infract size of the brain were quantified using triphenyltetrazolium chloride staining.

Results: Global cerebral ischemia causes long term memory impairment, decreases motor performances and increases the brain infract size in animals. The delivery of remote ischemic preconditioning stimulus significantly abolished the long-term cognitive impairment and ameliorates the motor performances as well as cerebral infract size in brain.

Conclusion: The remote ischemic preconditioning mediates neuro protection against global cerebral ischemic injury induced long-term cognitive impairment.
The Therapeutic Mechanism of COVID-19
Authors: Tanabe Shihori
Published: November 2020

The coronavirus disease-19 (COVID-19) is circulating all over the world. To understand and find a way of the COVID-19 treatment, the therapeutic mechanism of COVID-19 is focused on in this Editorial. The pathogenesis of COVID-19 includes the molecular networks such as the binding of the membrane proteins, signaling pathways and RNA replication. The mechanism of infection and targets of the therapeutics are explored and summarized. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is a new type of the coronavirus causing COVID-19, infects the cells via the binding of the membrane proteins of human cells, and is internalized by the cells. The viral genome is replicated by RNA-dependent RNA polymerase (RdRp), followed by the packaging and releasing the viral particles. These steps can be main targets for the therapeutics of COVID-19. On the other hand, over-driven immune responses, so-called “cytokine storm” is one of the main causes of the severe COVID-19. These immune responses are also important targets for the therapeutics of severe COVID-19. In this Editorial, some of the insights in the rapidly increasing abundant research reports on COVID-19 are introduced for the future acceleration of the therapeutic development.
Tremendous Contribution of Dr. Shahid Ullah to Scientific Community during COVID-19 Pandemic in the Form of Scientific Research
Authors: Khan Sher Ali
Published: November 2020

Legends are often the leading indicators of progress, civilization, culture for society and especially for the scientific community. The world is running on such beneficent, diligent, and creative-mind people, which sacrificing their precious time of life for the aid of society. Dr. Shahid Ullah is one of those who tried day night for humanity and have provided a great platform for the scientific community as well as for local researcher in the form of S Khan Lab, which has all updated biological databases of all research area that were not been provided on such friendly finding forum. The purpose of biological databases is to store, organize and distribute data in a standardized and searchable manner to facilitate the processing and visualization of data for humans. Taken together he has collected all biological databases to one easy and friendly finding manner platform which is available at http://www.habdsk.org/ with timely updates. Further, he has also provided two databases on the Covid-19, a global challenge for the scientific community recently.
Comparison on Effects of Temperature on Different Strains of Phytase Producing Bacteria Isolated from Malaysia’s Hot Spring
Authors: Anis Adilah Mustafa  , Nurul Asma Hasliza Zulkifly  , Afnani Alwi@Ali  , Tajul Afif Abdullah  , Nadiawati Alias
Published: November 2020

The main purpose of this research was to find the best growth curve for bacterial growth and the optimum temperature for the production of phytase from different potential phytase producing bacterial strains. A total of four strains used were originally isolated from hot springs in Malaysia, which were in Labis, Johor (L3), Dusun Tua, Selangor (RT), Ulu Legong, Kedah (A) and Ranau, Sabah (B9). Nutrient Agar (NA) and modified Phytase Screening Medium (PSM) liquid media were used for the culture enrichment while optimisation was carried out through batch culture method using a shake-flask scale. Strains growth and enzyme activity were quantitatively measured at different temperatures at (30°C and 37°C) values. Enzyme activity was determined according to the reaction of the phytase with its substrate (sodium phytate) and expressed in units of phytase activity (U/ mL). As for the overall, strain L3 (from Labis, Johor) exhibit promising rate of Pi released in the media at 30°C and 37°C, with optimum phytase activity values of 0.2047 U/mL and 0.2195 U/mL, respectively. The pH of the cultures was also measured, where it shows that strains grown in cultures at 37°C produced a higher phytase activity and resulting a lower reading of pH compared when grown at 30°C. All around, L3 strains has the lowest value of pH when cultured at 30°C and 37°C, with the pH value of 3.62 and 2.37, respectively.  From the result obtained, the lower pH indicates the process of phytic acid degradation take place by the phytase in producing inorganic phosphate (Pi) due to the accumulation of organic acid. Since these bacterial strains were originally taken from Hot Springs, further analysis of temperature optimization using 55°C and even 60°C should be carried out. In the future, biochemical research and molecular identification may also be carried out to identify molecular identity in the strains.
MANAGEMENT ACCOUNTING AS A DIRECTION OF THE STRATEGIC MANAGEMENT PROCESS
Authors: Natarova Elena Vladimirovna
Published: November 2020

Strategic management accounting has developed over the past thirty years, but there is still no agreement in the academic literature in terms of understanding the concepts and methods of this area of accounting. The adaptation of methods of strategic management accounting depends on the point of view on the concept of strategic management itself. To achieve competitive advantages, various concepts and applications of accurate strategic management accounting have been developed and studied, which becomes a challenge for accounting practices when providing up-to-date information in the process of making strategic decisions for the company.
The article examines the concept of «strategic management accounting», discusses the development of this direction in accounting, and also presents the results of a study conducted under the auspices of the Royal Institute of management accounting, devoted to the question of the extent to which management accounting supports the process of strategic management.
DYNAMICS OF ECONOMIC CRIME MARKERS OF THE REPUBLIC OF CRIMEA
Authors: Zinovjev Igor Feliksovich , Reutov Viktor Evgenievich
Published: November 2020

Considering economic crimes (CEC), as a characteristic of the relationship between the factors of the socio-economic life of the territory with crime (reflecting the dynamics of the gap between the needs of the population of the region and the degree of their actual satisfaction), it becomes possible to start modeling the predictive dynamics of emerging and realized trends in the structure of economic crime in the Republic. Crimea. Revealing the territorial specifics of CEC in the region will make it possible to plan measures to concentrate measures of state influence on the sphere of factors that predetermine the predicted dynamics of economic crime and to prevent direct material damage from a possible negative state, functioning and development of the Crimean society.
The criminological analysis of quantitative indicators of the dynamics of economic crime (with all the reservations about the incompleteness of the provided statistical data for PES and their distortions) does not allow (with the demanded depth of consideration) to distance the problems of various aspects of accounting for crime in this area and the factors that predetermine its specificity in the region. In order to increase the validity and information richness of the analysis of the territorial specifics of CEC, the author’s calculated «markers» were proposed that reflect one or another aspect of economic crime, as well as dynamic trends in its structure and / or nature. Based on the analysis of marker indicators, a characteristic of the region’s economic crime was compiled and a forecast scenario for the development of trends in the CEC of the Republic of Crimea was proposed.
Analisis Yuridis Perkawinan Dibawah Umur Melalui Kewenangan Kantor Urusan Agama (Studi Kasus di KUA Kabupaten Bantaeng)
Authors: Hamzah Yuli Adha , Mangarengi Arianty Anggraeny , Buana Andika Prawira
Published: November 2020

Dewasa ini marak terjadi perkawinan dibawah umur yang menyebabkan implikasi hukum yang negatif, salah satu daerah yang menjadi tempat maraknya prakter tersebut terdapat di kabupaten bantaeng, dimana perkawinan dibawah umur terus terjadi dan mulai meresahkan masyarakat. Tujuan penelitian ini adalah ingin mengetahui kewenangan Kantor Urusan Agama terhadap legalitas perkawinan dibawah umur serta untuk mengetahui faktor - faktor yang mempengaruhi terjadinya perkawinan dibawah umur. Penelitian ini menggunakan tipe penelitian kualitatif dengan pendekatan yuridis empiris. Penelitian ini dilaksanakan di Kantor Urusan Agama Kabupaten Bantaeng. Hasil penelitian ini menunjukkan bahwa tidak efektifnya pelaksanan Undang - Undang Perkawinan karena masih terdapatnya beberapa perkawinan dibawah umur yang terjadi dengan dalih adanya permohonan dispensasi perkawinan serta masih terdapatnya beberapa penyimpangan - penyimpangan hukum dalam hal prosedur pelaksanaan perkawinan dibawah umur oleh oknum Kantor Urusan Agama, dan hasil penelitian lain menunjukkan terdapat 5 (lima) faktor yang mempengaruhi kewenangan Kantor Urusan Agama terhadap legalitas perkawinan dibawah umur antara lain faktor pengetahuan hukum, faktor aparat hukum, faktor budaya hukum, faktor hamil diluar nikah dan faktor ekonomi. Faktor-faktor tersebut menjadi alasan kuat mengapa perkawinan dibawah umur ini masih terus terjadi.

Abstract. Nowadays underage marriages are rampant which causes negative legal implications, one of the areas where this practice is rampant is in Bantaeng district, where underage marriages continue to occur and begin to disturb the community. The purpose of this study was to determine the authority of the Office of Religious Affairs on the legality of underage marriage and to determine the factors that influence the occurrence of underage marriage. This study uses a qualitative research type with an empirical juridical approach. This research was conducted at the Office of Religious Affairs in Bantaeng Regency. The results of this study indicate that the implementation of the Marriage Law is ineffective because there are still several underage marriages that occur on the pretext of the existence of applications for marriage dispensation and there are still several legal irregularities in the procedure for implementing underage marriage by persons in the Office of Religious Affairs, and the results Other research shows that there are 5 (five) factors that influence the authority of the Office of Religious Affairs on the legality of underage marriage, including legal knowledge, law enforcement factors, legal culture factors, extramarital pregnancy factors and economic factors. These factors are strong reasons why underage marriages continue to occur.
FİNANSAL YAPILANDIRMA İŞLEMLERİNİN KAVRAMSAL ÇERÇEVE VE TFRS 9 KAPSAMINDA FİNANSAL TABLOLARA ETKİSİ: ÖRNEK UYGULAMA
Authors: ÖZDOĞAN Burak
Published: November 2020

Ekonomik kriz dönemlerinde işletmeler, nakit akışlarındaki bozulmalar neticesinde finansal yükümlülüklerini yönetmede güçlük çekmektedir. Bu dönemlerde, işletmenin nakit akışlarını yeniden sürdürülebilir bir şekle dönüştürebilmek adına finansal yapılandırma işlemleri önemli bir araç olarak değerlendirilmektedir. Türkiye’de de son yıllarda büyük ölçekli yükümlülükleri bulunan kurumsal şirketler finansal yeniden yapılandırma sürecine girmiştir. Ancak yeniden yapılandırma işlemleri her ne kadar işletmeleri nakit akışı bakımından rahatlatsa da finansal tablolar üzerinde etkiler bırakmaktadır. Bu durum işletmelerin uzun vadeli finansal görünümlerini de etkileyebilecektir. Çalışma ile, finansal yeniden yapılandırma işlemlerinin finansal raporlama standartları kapsamında işletmelerin finansal tablolarına yönelik olası etkileri teorik çerçevede ve bir örnek üzerinden tartışılarak yorumlanmıştır.
The Use of Partograph Bugis Midwives Application as a Learning Media for Normal Labor Care by Lecturers and Land Preceptor
Authors: Haeriah Musmir , Ahmad Mardiana , Sinrang Wardihan , Syarif Syafruddin
Published: November 2020

This article aims to discuss the design of a web-based Bugis Midwife application as a learning medium for normal childbirth care for lecturers in terms of improving the skills of providing normal delivery care and filling out student partographs and SOAP before going to the field. The type of research used in this research is Research and Development (RnD). The test analysis uses the experimental design model One Group pretest - posttest Design to see whether the application of web-based Bugis Midwives can be better in improving the provision of normal delivery care for students, with a sample of 40 students divided into two groups, a small sample of 10 people and a sample 30 people then analyzed the data using the Wilcoxon Test on SPSS. The results of the posttest after using the application for 3 weeks showed that there were 28 students who scored above 75 with the pass category (93.33%) and there were 2 students who scored below 75 with the category of still needing guidance (6.66%). Furthermore, based on the Wilcoxon test, the results obtained were P value 0.00 <0.05, which means that there is a significant difference between the pretest and posttest scores with the pretest average value of 74 with a sufficiently increased category in the posttest score to 82 in the good category. Based on the analysis of the test results, there is an increase in student learning outcomes on the post-test scores, so the web-based learning media application of the Bugis Midwife is more effective in increasing the knowledge and skills of students.
A bűnszervezetben történő elkövetés megállapíthatóságának ítélkezési gyakorlata a kábítószer-bűnözés vonatkozásában 1.
Authors: Nagycenki Tamás
Published: November 2020

The author provides an overview of the judicial practice of organized narcotics crime in Hungary.
Természetvédelem nemzetközi szinten és az Európai Unióban
Authors: Tilki Katalin
Published: November 2020

The author provides an overview of the most important environment protection strategies, programs, and the legal framework in Hungary.
A rendészet fogalmának, tartalmának evolúciója
Authors: Balla Zoltán
Published: November 2020

In order to pay tribute to the late Professor Géza Katona, the author provides an overview of the development of the concept of law enforcement.
Dohánycsempészet és a szervezett bűnözés
Authors: Rohács Roland , Molnár Sándor , Kozma Róbert , Dallos Szilárd
Published: November 2020

The authors provide an overview of the situation concerning organised crime and tobacco smuggling in the area of Szabolcs-Szatmár-Bereg County at the Ukrainian border of Hungary.
Genetic Polymorphisms Association in Restenosis of Coronary Arteries
Authors: Taizhanova Dana , Bodaubay Roza , Toleuova Aliya , Kalimbetova Akerke , Babenko Dmitriy , Turmukhambetova Anar , Akhmaltdinova Ludmila , Visternichan Olga
Published: November 2020

BACKGROUND: There is a reason to believe that the polymorphism of genes encoding some enzymes and receptors plays a role in increasing of restenosis development risk. It is common knowledge that ethnicity affects the frequency of heterozygous genotypes occurrence. There is the evidence that polymorphism of the FGB gene (rs1800790) and THBD gene was determined in the ethnic group of Kazakhs with restenosis of the coronary arteries, which can be considered as genetic predictors of restenosis development. Today, the questions of the role of the genetic component in the development of coronary heart disease (CHD) remain open.
AIM: Evaluation of gene polymorphism in patients with restenosis of coronary arteries after stent installation.
MATERIALS AND METHODS: The group consisted of Kazakh population of the age category from 45 to 65 years of both sexes: Group I (50 persons) patients with a diagnosis of CHD, with a fixed stent and the development of restenosis during the year; Group 2 (58 persons) – with a fixed stent and no restenosis during the year. The association of genetic polymorphisms was evaluated in accordance with the case–control design based on the generalized linear model assuming a log-additive inheritance model.
RESULTS: Thus, when comparing two groups using five patterns of inheritance, the following SNP were revealed: Codominant inheritance pattern – rs1045642 (p = 0.0427), dominant inheritance pattern – rs12041331 (p = 0.036088), rs13431554 (p = 0.025461), and rs1045642 (p = 0.012774), and overdominant inheritance pattern – rs12041331 (p = 0.051736), rs5918 (p = 0.057652), and rs13431554 (р = 0.036006). Thus, three SNPs associated with stenting were identified: rs7543130 (p = 0.009324), rs6785930 (p = 0.016858), and rs7819412 (p = 0.061325) and two SNPs associated with the development of restenosis after stent placement: rs1061781 (p = 0.063184) and rs342293 (p = 0.061636).
CONCLUSION: The polymorphisms associated with the risk of developing restenosis after stenting were determined: Codominant inheritance pattern – one polymorphism (rs1045642, p = 0.0427); dominant inheritance pattern – three polymorphisms (rs12041331, p = 0.036088; rs13431554, p = 0.025461; rs1045642, p = 0.012774), and overdominant inheritance pattern – one polymorphism (rs13431554, p = 0.036006). Based on the hybrid machine learning approach (RuleFit), four rules were obtained for assessing the empirical risk of restenosis developing after stenting – from 20% to 40%.
Effects of Electronic Technology Antenatal Care (E-ANC) on Midwives and Pregnant Women during the COVID-19 Period
Authors: Nur Rosmala , Radiah St. , Aulia Ulfa , Rahma Dwilarasati Rahma , Patui Nurhaya S. , Mantao Elvaria , Hendra Syaiful , Ngemba Hajra Rasmita , Rusydi Muh , Dominggo Nenita P.
Published: November 2020

BACKGROUND: Pregnant women are considered as a risk group for exposure to COVID-19. Changes in their hormones and immune systems possibly influence their rate of infection by several viruses, including the coronavirus. This stresses the need to observe necessary precautions, by maintaining social distancing, avoiding crowds, and staying at home. Furthermore, the condition also influences the scope of pregnant women’s antenatal visits.
AIM: The study aims to determine the effect of COVID-19 on antenatal visits by pregnant women. Furthermore, it seeks to ascertain the effect of electronic technology antenatal care (e-ANC) on the enhanced participation of midwives and pregnant women in antenatal care (ANC) (i.e., counseling, high-risk early detection on pregnancy, and monitoring of Hb and Fe tablets). Therefore, the impact COVID-19 on women’s reproductive health during the pandemic is also evaluated.
METHODS: This research involved pre- and post-test experiments on 30 pregnant women and 20 midwives at areas around the Public Health Centers in Tinggiede and Marawola. A purposive sampling technique was adopted, and the results were analyzed using a paired t-test.
RESULTS: The study showed discrepancies in the ANC visits of pregnant women before and after the COVID-19 lockdown period, with p < 0.00. Furthermore, there were also differences in midwife participation in counseling by p < 0.00, high-risk early detection on pregnancy by p < 0.001, Hb monitoring by p < 0.002, and provision of Fe tablets by p < 0.003 during the pandemic. Moreover, the pregnant women showed variations in the frequency of counseling by p < 0.00, high-risk early detection on pregnancy by p < 0.00, Hb monitoring by p < 0.002, and the provision of Fe tablets by p < 0.003. The e-ANC instigated a decline in reproductive health problems before (73.4%) and after (10.0%) the intervention.
CONCLUSION: The lockdown period influences the low antenatal visits of pregnant women. However, e-ANC for midwives and pregnant women is developed as an alternative solution to improve ANC (i.e., counseling, high-risk early detection, and monitoring Hb and Fe tablets). This consequently has an effect on the reduced reproductive health problems of pregnant women during the pandemic.
Amelioration of Murine Autoimmune Pancreatitis by Targeted LTβR Inhibition and Anti-CD20 Treatment
Authors: Wanner-Seleznik Gitta M , Reding Theresia , Chen Rong , Gupta Anurag Kumar , Lenggenhager Daniela , Browning Jeffrey , Segerer Stephan , Heikenwalder Mathias , Graf Rolf
Published: November 2020

Autoimmune pancreatitis (AIP) is a rare form of chronic pancreatitis, for which treatment options, especially the long-term management, are limited. The only therapy that has been established and accepted so far is corticosteroids, but the relapse rate is significant. In the current study, we discern the effector mechanisms of targeted LTβR pathway inhibition using LTβR-Ig. Furthermore, the efficacy of LTβR-Ig therapy is compared with the depletion of immune cell subsets (CD4+ and CD20+), which are suggested to play a pathological role in AIP development. Three well-established mouse models of AIP were used to examine treatment efficacies and mechanisms. Tg(Ela1-Lta,b) mice represent a genetic model, in which AIP develops spontaneously. In MRL/Mp and IL-10−/− mice, AIP is induced by repeated polyinosinic:polycytidylic acid injection. Mice with AIP were treated with anti-CD20, anti-CD4 mAbs, or targeted LTβR-Ig. LTβR-Ig and anti-CD20 treatment led to significant improvement of AIP, including a decrease in autoantibody production and pancreatic inflammation in Tg(Ela1-Lta,b) and IL-10−/− mice. The molecular mechanism of this beneficial effect possibly involves the downregulation of Stat3 and noncanonical NF-κb activation. Anti-CD4 treatment reduced Th1 and Th2 signature but did not alleviate AIP. Additionally, in contrast to anti-CD20 or anti-CD4 treatments, blocking LTβR signaling disrupted tertiary lymphoid organs in all three models. We demonstrate that treatment with LTβR-Ig or anti-CD20 Ab alleviated murine AIP. LTβR-Ig treatment for AIP was effective in both lymphotoxin-dependent and lymphotoxin-independent AIP models, possibly because of its dual anti-inflammatory and antiautoimmune mechanisms.
Farmacogenetica e Farmacogenomica: aspettative e questioni etiche
Authors: Spagnolo A.G. , Minacori R.
Published: November 2020

La farmacogenetica è stata inizialmente definita come lo studio della variabilità di risposta individuale al farmaco legata all’ereditarietà e alle caratteristiche genetiche personali e familiari. Durante l’ultima decade il termine farmacogenomica ha ulteriormente affinato tale definizione delineando con più precisione gli ambiti e le finalità di questo nuovo ambito scientifico. L’obiettivo è ancora più affascinante e importante: sviluppare e utilizzare nuove terapie farmacologiche personalizzate, più efficaci e meno dannose, utilizzando le scoperte sul genoma umano.

Dallo sviluppo di questa nuova applicazione della genetica probabilmente dipenderà anche un mutamento nella prassi medica, con nuovi criteri diagnostici e soprattutto nella possibilità di somministrare delle terapie personalizzate.

La genomica applicata alla ricerca farmacologica, oltre alle diverse problematiche tecnico-scientifiche che ancora sono in via di risoluzione, impone anche, per l’ambito di applicazione - il genoma umano, quindi anche la persona umana, e le finalità che si prefigge cioè pervenire a nuove e ottimali soluzioni terapeutiche attraverso la ricerca clinica - un’ampia riflessione etica rispetto ad una pluralità di elementi in gioco.

D’altra parte occorre anche considerare che ai vantaggi di una quota di popolazione potrebbero correlarsi svantaggi terapeutici per altre fasce di popolazione minoritarie, perciò è fondamentale che un’ampia e articolata riflessione e adeguate soluzioni vengano intraprese prima che la commercializzazione dei tests farmacogenetici possa causare discriminazioni tra i pazienti.

Nell’articolo, gli Autori evidenziano le questioni etiche relative alla ricerca farmacogenetica di base, all’identificazione, alla collezione e alla brevettabilità dei dati, alla ricerca farmacogenetica applicata, con lo sviluppo di dispositivi diagnostici e il loro uso nelle sperimentazioni cliniche, alle procedure per la conservazione e dei campioni biologici e dei dati e per la tutela della riservatezza, al ruolo dei Comitati di Etica nella valutazione dei protocolli sperimentali di farmacogenetica, al consenso informato per i soggetti di sperimentazione.
La comunicazione medico-paziente: elementi per una fondazione etica
Authors: Carrasco De Paula Ignacio
Published: November 2020

L’articolo prende in esame gli aspetti etici di un tipo particolare di comunicazione, quella tra il medico e il suo paziente.

L’Autore introduce l’argomento con alcune osservazioni di natura storicodottrinale (dialettica tradizione-modernità) e prosegue con una riflessione sulle categorie e condizioni etiche pertinenti ad una attività specificamente umana e, pertanto, morale, quale è la comunicazione tra il medico e il paziente.

In particolare, vengono trattate le seguenti questioni: a. pregi e limiti della comunicazione medico-paziente nella medicina tradizionale (Corpus Ippocratico); b. l’avvento della tecnologia nella medicina della modernità (conquiste e insidie); c. le basi etiche della comunicazione medico-paziente nel contesto clinico.
Il dibattito in bioetica - Il consenso informato tra teoria e pratica
Authors: Ermini M.
Published: November 2020

Non disponibile.
Il dibattito in bioetica - Istanze etiche dei trapianti di organi “non salvavita”
Authors: Cozzoli Mauro
Published: November 2020

Non disponibile.