bluuebunny/crossref_metadata_2025 huggingface dataset:
HR-ANALYST: ACHIEVEMENTS, CAPABILITIES AND CONDITIONS OF USE
Authors: Коновалова  , Konovalova Valyeriya
Published: March 2017

The article deals with problems of HR analytics and its practical application to improve management decisions of individual and organizational performance. The results of Russian and foreign research on the current state of and prospects for the use of HR analysts are summarizes. The levels of HR analysts (from the drafting of HR-metrics to predictive modeling) are allocated, their characteristics are disclosed. The examples of the successful use of HR analysts in modern practice are given, special attention is paid to predictive analysts, the author highlights the potential benefits of organizing, its use for a wide range of tasks: forecasting staffing needs, forecasting staff turnover, improving recruitment, better interaction management talent, identifying the most valuable employees, corporate culture and management involvement, identifying key factors for motivation and success, increase staff productivity, increase efficiency of training and formation of competencies.
SOCIAL POLICY DEVELOPMENT OF PERSONNEL POTENTIAL OF THE ENTREPRENEURIAL SPHERE
Authors: Анохин  , Anokhin S.
Published: March 2017

The article is aimed at addressing key problems of national economy with the impact on it personnel potential of any organization and in particular companies of the business sector. The article assesses the social policy, conditions and factors influencing efficiency of formation and development of personnel potential of the enterprise sector of the economy. It justified recommendations for their improvement, and also shows the effect of the level of development of personnel potential in this sphere to increase efficiency of the domestic economy as a whole. At the same time drawn attention to the solution of the problems of the large industrial companies compared to small and medium organizations engaged in entrepreneurial activities. The article shows to attract and develop talented employees in terms of business structures, it is necessary that the newly created state bodies on creation of conditions for their development first of all drew attention to the condition of personnel potential of business sector, principles, methods and technologies of its formation and also to ensure its effective development. According to the author the solution to this problem is the unused resources.
INFLUENCE OF THE VOCATIONAL EDUCATION SYSTEM ON THE DEVELOPMENT OF THE FAR EASTERN FEDERAL DISTRICT LABOR RESOURCES
Authors: Опарина  , Oparina Natalya , Панова  , Panova E.
Published: March 2017

In this article the authors reflected the current state of vocational education and the influence of all the problems of the system on the state of the labor force. The quantity, quality and education areas of the high schools and colleges have been analyzed, the number of graduates, the realities and possibilities of their employment, the needs of employers for skilled workers in specific professions, government policies in attracting and retaining young people in the region and so forth. The article focuses on identifying the main challenges and constraints of professional education and determining the strengths and capabilities of the system development in the region. The article presents the results of research conducted by the lecturers of the Faculty of Public Administration Lomonosov Moscow State University. The study was devoted to the analysis of the labor resources of the Far Eastern Federal District and the territories of priority development in the 2014–2015.
FORMATION OF SOFT SKILS: APPROACHES TO INTEGRATING RUSSIAN AND FOREIN EXPERIENCE, CLASSIFICATION, OPERATIONALIZATION
Authors: Чуланова  , Chulanova Oksana , Ивонина  , Ivonina A.
Published: March 2017

The article examines the approaches of Russian and foreign researchers in the formation of soft skills, the common elements and differences in classifications of existing approaches are denoted. The authors emphasize the fundamental difference between the competencies of skills. The article also discusses the concept of emotional intelligence and communication of the characteristics of the development of emotional intelligence. The paper emphasizes the importance of a high level of emotional competence leader and their impact on the achievement of organizational goals. Awareness of the head of the need to develop their emotional intelligence and taking action for this will increase employee productivity, customer loyalty, speed the introduction of changes to the business model. The authors refer to a place of emotional competencies in soft skills model. In work the operationalization of soft skills with the release of emotional competencies in a separate category.
DEVELOPMENT OF COMPETENCES MODEL OF THE HR MANAGER
Authors: Конькова  , Konkova E. , Ливак  , Livak N.
Published: March 2017

In article the most urgent requirements to employees in modern economic conditions of crisis are stated. The concepts “competence”, “human resources manager” are specified. A main objective of article is development of model of competences of the human resources manager on the main clusters of competences, levels and indicators of behavior. On the example of LLC Machine Works the analysis of labor functions of HR specialists according to requirements of the professional standard is carried out. During the analysis and comparison of the professional standard of the HR manager and the job description of the human resources manager discrepancy of the name of a position was revealed. Upgrade of personnel department for elimination of the revealed shortcomings is offered, “human resources manager” is developed For a position model of competences. The system of assessment of competences is provided. Content of model of competences, accurately

and specifically stated in behavioural indicators, allows to impose single requirements to the staff of various structural divisions.
Robust Dynamic Estimation
Authors: Rubel Olivier , Naik Prasad A.
Published: March 2017

Managing marketing resources over time requires dynamic model estimation, which necessitates specifying some parametric or nonparametric probability distribution. When the data generating process differs from the assumed distribution, the resulting model is misspecified. To hedge against such a misspecification risk, the extant theory recommends using the sandwich estimator. This approach, however, only corrects the variance of estimated parameters, but not their values. Consequently, the sandwich estimator does not affect any managerial outcomes such as marketing budgeting and allocation decisions. To overcome this drawback, we present the minimax framework that does not necessitate distributional assumptions to estimate dynamic models. Applying minimax control theory, we derive an optimal robust filter, illustrate its application to a unique advertising data set from the Canadian Blood Services, and contribute several novel findings. We discover the compensatory effect: Advertising effectiveness increases and the carryover effect decreases as robustness increases. We also find that the robust filter uniformly outperforms the Kalman filter on the out-of-sample predictions. Furthermore, we uncover the existence of a profit-volatility trade-off, similar to the returns-risk trade-off in finance, whereby the volatility of profit stream decreases at the expense of reduced total profit as robustness increases. Finally, we prove that, unlike for-profit companies, managers of nonprofit organizations should optimally allocate budgets opposite the advertising-to-sales ratio heuristic; that is, advertise more (less) when sales are low (high).

Data and the web appendix are available at https://doi.org/10.1287/mksc.2016.1010 .
Tests, scans and investigations, 8: CT scan
Authors: Peate Ian
Published: March 2017

There are a number of medical imaging procedures that are undertaken with the aim of making a diagnosis or to assess a patient's response to treatment or their disease progression. Computerised tomography (CT) scanning is one commonly performed imaging technique. This article provides the reader with a fundamental understanding of CT scanning, the reason why such a scan may be requested and how the scan is performed. The potential risks associated with this procedure are discussed.

The role of the healthcare assistant and the assistant practitioner (HCA and AP) is outlined before, during and after the procedure has been performed.
In-hospital cardiac arrest epidemiology in a mature rapid response system
Authors: Jones Daryl , Mercer Inga , Heland Melodie , Detering Karen , Radford Sam , Hart Graeme , O'Donnell David , Bellomo Rinaldo
Published: March 2017

An audit examined the epidemiology of in-hospital cardiac arrests 5 years after a rapid response system was introduced, exploring the frequency of arrests in monitored and unmonitored areas. Details of the initial cardiac rhythm and what proportion of events were preceded by a medical emergency team call were also assessed.
Reversal of direct oral anticoagulants
Authors: Zhang X-Y , Desborough MJ , Shapiro S
Published: March 2017

An understanding of how to counteract the anticoagulant effect of direct oral anticoagulants is essential in the event of haemorrhage, emergency surgery and overdose. This review summarizes strategies for the reversal of direct oral anticoagulants, including the use of novel agents.
Successful outpatient management of lymphoedema and lymphorrhoea with wrap around compression: a case study
Authors: Patullo L. , Rajagopalan S.
Published: March 2017

Referral to specialist centres for treatment of lymphoedema can often have long waiting times. Management of a patient with massive lymphoedema and lymphorrhoea was provided in a vascular outpatient setting. A new form of compression using a wraparound system was used for the management (Juxta-Fit, Medi UK). Despite having previously been non-concordant with treatment options, the patient was independent with product use. Lymphorrhoea ceased and there was a marked decrease in girth size. The patient's quality of life improved and maintenance treatment was provided. The use of this compression system could be a valuable treatment alternative to compression bandaging for a select patient group for the treatment of lymphoedema.
Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: a systematic review
Authors: Totty J.P. , Bua N. , Smith G.E. , Harwood A.E. , Carradice D. , Wallace T. , Chetter I.C.
Published: March 2017

Objective:

Dialkylcarbomoyl chloride (DACC)-coated dressings (Leukomed Sorbact and Cutimed Sorbact) irreversibly bind bacteria at the wound surface that are then removed when the dressing is changed. They are a recent addition to the wound care professional's armamentarium and have been used in a variety of acute and chronic wounds. This systematic review aims to assess the evidence supporting the use of DACC-coated dressings in the clinical environment.

Method:

We included all reports of the clinical use of DACC-coated dressings in relation to wound infection. Medline, Embase, CENTRAL and CINAHL databases were searched to September 2016 for studies evaluating the role of DACC-coated dressings in preventing or managing wound infections.

Results:

We identified 17 studies with a total of 3408 patients which were included in this review. The DACC-coating was suggested to reduce postoperative surgical site infection rates and result in chronic wounds that subjectively looked cleaner and had less bacterial load on microbiological assessments.

Conclusion:

Existing evidence for DACC-coated dressings in managing chronic wounds or as a surgical site infection (SSI) prophylaxis is limited but encouraging with evidence in support of DACC-coated dressings preventing and treating infection without adverse effects.
In situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections
Authors: Masood R. , Hussain T. , Umar M. , Azeemullah  , Areeb T. , Riaz S.
Published: March 2017

Objective:

The purpose of the study was the development of a suture line that has antibacterial properties and reduces the chance of wound infection thus facilitating the healing process.

Method:

Hydrolysed chitosan, turmeric powder and clove oil were used in different proportions to formulate antimicrobial coating for the polyethylene terephthalate (PET) and polyamide (Nylon 6) threads. The threads were coated using a lab-scale yarn sizing machine. Tensile, and knot strength of the coated sutures were measured. As was the antimicrobial action of Staphylococcus aureus strain ATCC29213.

Results:

The results show that coatings have slightly improved the tensile and knot strength properties of these sutures. The coated sutures also have satisfactory microbial inhibition against Staphylococcus aureus.

Conclusion:

The coating slightly improved the tensile strength of the sutures. However, the knot is the weakest part of the suture strand. All the formulations of the coating have shown satisfactory antimicrobial activity against Gram-positive Staphylococcus aureus bacteria. We conclude that application of natural coatings on non-absorbable sutures can be useful to reduce the incisions and wound site infections.
Intensive care unit nurses' perceived barriers towards pressure ulcer prevention in south east Iran
Authors: Mirshekari L. , Tirgari B. , Forouzi M.A.
Published: March 2017

Objective:

Pressure ulcer (PU) prevention is one of the most important roles of nurses in intensive care units (ICUs). This study was conducted to identify intensive care registered nurses' perceived barriers towards PU prevention in south east Iran.

Method:

This study employed a descriptive cross-sectional design. A convenience sample consisted of registered nurses working in trauma intensive care units affliated by Zahedan Medical University participated in this study. Data were collected using the barriers to providing prevention of pressure ulcers quesionnaire.

Results:

The response rate was 100 % (n=88), although not all participants answered every question. The results showed that 78% were women. The mean age of participants was 30.2 years. The item ‘heavy workload/staff shortage’ perceived highest barrier towards pressure ulcer prevention (mean±standard deviation (SD): 3.37 ± 0.66). The item ‘uncooperative patients' achieved the lowest perceived barriers score (mean ± SD: 2.65 ± 0.75). Nurses who had more nursing experience in an ICU setting perceived barriers more than those with less nursing experience in ICU setting. Those who had no previous exposure to PU prevention education perceived barriers more than those had previous exposure to PU prevention education.

Conclusion:

Understanding ntensive care registered nurses' perceptions of PU prevention barriers will enable nurse leaders to develop a variety of intensive teaching to disseminate information about these barriers.
Reducing and rationalising antimicrobial use in the treatment and control of bovine mastitis
Authors: Hyde Robert , Fitzgerald Katie , Down Peter , Remnant John
Published: March 2017

The use of antimicrobials in food producing animals receives much attention and is highlighted as a focus in the efforts against antimicrobial resistance documented in the O'Neil report (2015) , with DEFRA committing to a <50 mg/kg antimicrobial usage across farmed species. Veterinary surgeons must work with their clients to achieve this aim in such a way that does not compromise animal health or productivity. The control and treatment of mastitis is one of the most common reasons for antimicrobial use on UK dairy farms and offers an opportunity for veterinary surgeons to engage in both reducing and rationalising use of antimicrobials in dairy cattle.
Foot lameness in goats: like sheep, like cattle or completely different?
Authors: Groenevelt Margit
Published: March 2017

As lameness can cause significant losses in both welfare and production it is an important topic for all livestock. Goats are generally underrepresented in scientific papers, so we often refer to information from other species or our own experience when dealing with a lame goat, whether it is an individual pet goat or a herd problem. In recent years, however, more goat specific knowledge on lameness has surfaced. It seems goat lameness is as the animal itself, seemingly similar to other species but with a wholly different character.
Research roundup: March 2017
Authors: Greener Mark
Published: March 2017

In brief

Diabetes and hyperlipidaemia seem to increase independently the risk of back, neck and shoulder pain Verapamil might effectively treat chronic rhinosinusitis with nasal polyps, initial results suggest Talking pill bottles seem to enhance hypertension control and are well accepted by patients with poor health literacy Statins might increase the risk of spontaneous miscarriage
A tool that may help to tackle atrial fibrillation
Authors: Thomas Simon
Published: March 2017

Untreated atrial fibrillation can increase the risk of stroke by up to six times, but its management presents a considerable resource challenge. A joint working group has created an online tool to help practitioners and patients, Simon Thomas explains
Polypharmacy and older people
Authors: Kaufman Gerri
Published: March 2017

The use of polypharmacy (multiple medicines) is increasingly common in older people. There is no consensus on a clinical definition of polypharmacy and so it is often defined using a simple numerical threshold. However, current perspectives recommend that polypharmacy is classified as either ‘appropriate’ or ‘problematic’.

Older people are especially vulnerable to the effects of polypharmacy because of altered physiology and the existence of comorbidities. The use of single evidence-based guidelines to manage comorbidities can cause problematic polypharmacy, and fears about polypharmacy can lead to under-prescribing.

A range of interventions are available to improve the appropriate use of prescribing in older people.

Considering the clinical context of polypharmacy alongside an awareness of its perils is important to ensure the benefits of using multiple medicines are balanced against the potential harms.
Introduction to pharmacokinetics
Authors: Robertson Deborah
Published: March 2017

Pharmacology is an area many nurse prescribers, whether they are prescribing students or qualified prescribers, worry about. They are very aware of the importance of pharmacological knowledge and its impact on safe prescribing. Nurse prescribers typically want to know how much information they need and what depth and breadth that information should take. Another area they worry about is how many drugs they need to be familiar with. This series will explore some concepts in pharmacology to support the prescriber in developing that knowledge. This article begins by examining the basic concepts of pharmacokinetics to allow the reader to improve their understanding of drug handling within the body. It will explore the processes of absorption, distribution, metabolism and excretion to chart a drugs ‘route’ from administration to elimination.
Options for continuing professional development
Authors: Cox Ella
Published: March 2017

Ella Cox considers the benefits, both in terms of her own professional development and advantages for her employer, of undertaking a master's in advanced practice
Letting patients die a natural death
Authors: Nazarko Linda
Published: March 2017

Death is a natural part of life, so why are we so inclined to over-treat dying patients? Linda Nazarko addresses the tendency to investigate and over-treat frail, terminal patients
Why lasting powers of attorney matter
Authors: Jamieson Jessica
Published: March 2017

Many people know about financial powers of attorney but, for GPs, health and care powers are much more relevant. Jessica Jamieson, a partner at law firm Cripps, explains their significance
How to manage next year's tax bills
Authors: Bennett Luke
Published: March 2017

Accountant Luke Bennett explains why practice managers need to take action now to plan for bigger tax bills for some of their GP partners
Making a success of a merger
Authors: Taylor Keith
Published: March 2017

What is the attraction of a practice merger? A better chance of bidding for contracts? The pursuit of economies of scale? Making administration more efficient? Keith Taylor looks at some of the arguments in detail
Algunas reflexiones sobre la información contable de los empresarios en la legislación mercantil. El deber de secreto y sus excepciones
Authors: Martínez Balmaseda Arantza
Published: March 2017

El objetivo de este trabajo es analizar el deber de llevanza de la contabilidad que pesa sobre el empresario con especial atención sobre la formulación de las cuentas anuales. Esta contabilidad presenta interés no solo desde el punto de vista interno de la empresa, como modo de organización del empresario, sino que también resulta valiosa desde el punto de vista de los terceros ( socios, acreedores, trabajadores) desde el momento que ofrece una importante información para la toma de decisiones. Por ello, el principio general de secreto de contabilidad reconocido en la legislación presenta importantes excepciones en atención a la tutela de estos terceros y en el que también centraremos nuestra atención.
Los derechos de información de la representación de las personas trabajadoras: límites legales y mejora a través de la negociación colectiva
Authors: Mata Diestro Héctor
Published: March 2017

En este artículo se aborda la necesidad de promover y reforzar la información y consulta de la representación de las personas trabajadoras en las empresas. Necesidad que aumenta en situaciones de crisis empresarial. Y ello, con la suficiente antelación, de forma que se puedan acometer con garantías los procesos de cambio. Para ello se procede a un análisis de la legislación, así como de la jurisprudencia, existente en relación a la información y documentación, tanto preceptiva como complementaria, a entregar por parte de las empresas. De lo cual se concluye la necesidad de potenciar, a través de la negociación colectiva, los llamados derechos de información, consulta, participación y control sindical. Para lo cual se realizan una serie de propuestas concretas.
Negociación colectiva y control sindical. Aspectos laborales y económicos
Authors: Iriarte Niko
Published: March 2017

En esta ponencia se informa sobre la actividad diaria del Gabinete de Negociación Colectiva del sindicato ELA: en los despidos colectivos sufridos, en los cierres de empresas, en los procesos concursales... Explicaremos cuál es la documentaciónque exigimos y la estrategia que pone en práctica nuestro sindicato., de cara aevitar esta difíciles situaciones. Queremos destacar el comportamiento de los grupos de empresas, las valoraciones (jurídicas) y no económicas que los jueces hacen de despidos por causas económicas y queremos subrayar, sobre todo, que las multinacionales hacen en casi todos los casos lo que quieren con el beneplácito del poder institucional. Para finalizar, se expone el Modelo Social del Sindicato ELA, que es el más importante de sus tres ejes estratégicos, junto con el trabajo sindical, sin olvidarnos del eje político.
No se ve, no se toca y sin embargo, existe: La esclavitud hoy. Hacia una reconceptualización del trabajo esclavo
Authors: Urrutikoetxea Barrutia Mikel
Published: March 2017

En este trabajo abordamos la cuestión de la esclavitud hoy. Para ello empezamos confrontando ciertos mitos sobre la misma, para a continuación aproximarnos a la importancia del fenómeno y a las formas que presenta hoy, matizando las diferencias entre la esclavitud tradicional y la contemporánea. Seguidamente analizamos los conceptos de esclavitud, trabajos forzados y servidumbre a la luz de las normas internacionales, así como las diferencias que existen entre estos conceptos. Posteriormente, nos dirigimos al derecho interno para acercarnos a las disposiciones sobre este fenómeno presentes en el Derecho español y tras constatar la ausencia de tipificación como delito del trabajo esclavo o el forzado, puntualizamos la diferencia entre explotación laboral y los trabajos coactivos. Y concluimos con un reconceptualización del trabajo coactivo que posibilite una intervención más eficaz sobre las formas contemporáneas de trabajo esclavo.
Perinatal factors associated with autistic spectrum disorder
Authors: Yuniastuti Asri , Wibowo Tunjung , Ismail Djauhar
Published: March 2017

Background The prevalence of autistic spectrum disorder(ASD) has increased in recent decades. The definitive causesof ASD have yet to be recognized. Howevei; it is believed thatboth genetic and non-genetic, as well as perinatal and post natalfactors influence ASD. Previous studies have shown inconsistentfindings.Objectives To assess for prematurity, birth weight, asphyxia,mode of delivery, bleeding during pregnancy, parental age andeducation, as prognostic factors for ASD.Methods We conducted a cross sectional study at schools forautistic children in Yogyakarta between February 2011 to October2012. The inclusion criteria were children with and without ASD,whose parents consented to participate in this study. Childrenwith genetic abnormalities or who planned to move away duringthe study period were excluded. A total of 48 subjects with ASDand 96 subjects without ASD were involved in this study. Datawere obtained by direct interview using questionnaires. Logisticregression analysis was performed to examine the hypoth esis.Results Multivariate analysis showed that prematurity was nota significant prognostic factor (RR 2.73; 95%CI 0.3 to 15.7) forASD. Howevei; children born by Caesarean section were 5.4 timesmore likely to have ASD (RR 5.4; 95%CI 1.3 to 22.8) comparedto those who were delivered vaginally or by vacuum extraction.Moreovet; asphyxia was also a significant prognostic factor forASD (RR 8.7; 95%CI 1.9 to 38.6) .Conclusion Prematurity is not a risk factor for ASD. Asphyxiaand Caesarean birth should be considered as potential confoundersin this study.
Serum transaminase levels and dengue shock syndrome in children
Authors: Putra Yoga , Arhana Bagus Ngurah Putu , Safitri Ida , Widiana Raka
Published: March 2017

Background Clinical and biochemical impacts on liverdysfunction, as manifested by an increase in serum transaminaselevels, are common in dengue infection. Howevei; an association ofelevated serum transaminase and dengue shock syndrome (DSS)has n ot been well-established.Objective To assess for an association between serum transaminaselevels and the presence of DSS in children.Methods A nested, case control study was conducted on childrenaged l month to 12 years admitted to Sanglah Hospital whowere diagnosed with dengue infection. Baseline characteristicsand serum transaminase levels were recorded. Patients who wereincluded in the study were observed for the presence of DSS.Those who had DSS were selected as cases, and those who did notdevelop DSS were selected as controls. Data was analyzed usingbivariate and multivariate methods with 95% confidence intervalsand P value <0.05 was considered as statistically significant.Results Ninety-four children were involeved, 4 7 children in thecase group and the other 4 7 were in the control group. Baselinecharacteristics of the subjects were similar between the case andcontrol groups. Serum aspart ate transaminase (AST) level of2:: 128 U/L and alanine transaminase (ALT) of 2: 40 U/L wereassociated with DSS (OR 10; 95%CI 2.3 to 44.4; P=0.002) and(OR 7 .3; 95%CI 1.6 to 32.9; P= 0.009), respectively.Conclusion Elevated AST and ALT levels were associatedwith an increased risk of DSS in children with dengue infection.
Pneumonia, air pollution, and sex differences.
Authors: Silveyra Patricia
Published: March 2017

Accumulating evidence indicates that exposure to air pollution is associated with increased mortality from respiratory disease. Exposure to ambient air pollutants has been associated with decreases in lung function and immunity, and with increased rates of hospitalization for lung disease, including pneumonia. Furthermore, sex differences in frequency and severity of pulmonary disease and infection have been reported. Pneumonia, which is commonly caused by bacterial infection and subsequent lung inflammation leading to hospitalization and death, occurs at different rates in men vs. women. This collection encompasses clinical, animal and epidemiological studies linking exposure to air pollution and pneumonia pathogenesis in males and females. This information is relevant for the development of more effective therapeutics and treatment options for patients suffering from pneumonia.
Ecofisiologia da cana-de-açúcar no sub-bosque de canafístula em arranjos de sistema agroflorestal
Authors: Elli Elvis Felipe , Caron Braulio Otomar , De Paula Gizelli Moiano , Eloy Elder , Schwerz Felipe , Schmidt Denise
Published: March 2017

The objective of this study was to evaluate physiological and thermal aspects of sugarcane, in North and South oriented lines, in ‘canafístula’ understory under two plant arrangements in an agroforestry system. The experimental design was a completely randomized block in a 2x2x6 factorial, with two agroforestry systems (strip and line), two evaluation lines (North and South) and at six times a day (9am, 10am, 12pm, 2pm, 3pm and 4pm) with three repetitions. The evaluated characteristics were: incident photosynthetically active radiation (RFA), leaf temperature (TF), resistance to vapor diffusion (RS) and transpiration (E) using a digital porometer LI-1600 LI-COR. Analysis of variance revealed differences for the interaction of agroforestry system x evaluation line x time, for all variables. The physiological and thermal characteristics of sugarcane are influenced by plant arrangement, agroforestry system and the local evaluation within the system. The strip system lead to a higher available amount of RFA in its understory, which reflects in increased RS values and reduced E of sugarcane. The South line presented higher E for sugarcane in the morning period in strip system and lower during the afternoon for the line system, due to higher TF values.
International Symposium for Thyroid Eye Disease (June 2016, London)
Authors: Sviridenko Natalia Y. , Sheremeta Marina S. , Grusha Yaroslav O.
Published: March 2017

В июне 2016 г. состоялся международный симпозиум, посвященный новейшим исследованиям и достижениям в решении проблем тиреоид-ассоциированной офтальмопатии (TED). Симпозиум был организован по инициативе международного общества по тиреоид-ассоциированной офтальмопатии – International Thyroid Eye Disease (ITEDs). В его работе принимали участие члены EUGOGO (Европейской группы по эндокринной офтальмопатии), NANOS (Северо-Американского нейроофтальмологического общества) и Orbit Society (Ассоциации орбитологов).В симпозиуме приняли участие ведущие специалисты в области офтальмологии, орбитальной хирургии и эндокринологии: Rebecca S. Bahn, Maarten Mourits, Claudio Marcocci, George Kahaly, Mario Salvi, Antony Weetman, Anja Eckstein, Geoff Rose, Robert Goldberg, Michael Kazim, Richard Collin, Christoph Hintschich, Don Kikkawa, Jonathan Dutton, Susanne Pitz, а также врачи, специализирующиеся в области эндокринологии, офтальмологии, радиологии и др. Проблемы ТED обсуждали более 300 специалистов (65% – офтальмологи, 18% – офтальмохирурги, 17% – эндокринологи) в основном из Европы. Северная Америка была представлена 50 делегатами, менее многочисленным было представительство других континентов.Программа симпозиума была сосредоточена на обсуждении механизмов развития ТED, классификациях и новых терапевтических и хирургических подходах к ее лечению.
Quadrature of the circle
Authors: Gerasimov Grigory A.
Published: March 2017

Насколько должны отличаться подходы в диагностике и лечению тироидной патологии между странами/регионами, в которых дефицит йода успешно устранен путем всеобщего йодирования соли, и теми местами, где сохраняется разной степени выраженности йодная недостаточность? Как должна изменяться диагностическая и лечебная тактика в отношении заболеваний щитовидной железы в период внедрения в стране программы всеобщего йодирования соли? Эти и другие вопросы обсуждаются в регулярной колонке "De Gustibus"
ANALISIS KUASA PADA PRAKTIK KELEMBAGAAN PA’TOTIBOYONGAN DI MAMASA
Authors: Junita Risma
Published: March 2017

This paper elaborates the issue of agricultural resources management processes based on local institution called pa’totiboyongan in the Village of Ballatumuka, Mamasa. This research employs a power analysis framework to analyze the management processes in distributing agricultural resources. In a practical level, the agricultural resource management processes have involved various actors who have different roles and interests. These different roles and interests reveal the patterns of power relations among the actors in forms of conflct, resistance, persuasion, and collaboration. Furthermore, the inflence of power relations among the actors on preserving the existence of pa’totiboyongan is clearly apparent. The result shows that the agricultural resources management processes are based on three important aspects: economics, ecological, and social-culture of  society.
MEMPOSISIKAN SANTRI DALAM PEMIKIRAN LIBERAL KEAGAMAAN DI INDONESIA
Authors: Saifuddin Saifuddin
Published: March 2017

A religious reaction against modernity has opened our eyes, that an argumentation in the thought zone at the end enters the empiric zone. As a result is a horizontal conflct that meets a fundamentalist and radical islamic group facing a tolerant Islamic group and has liberal thought. Islamic liberalism indeed is not always identical with the western liberalism, but has a strong tradition in islamic world. The root of thought which becomes an argument in islamic world apparently is too close in santry those who get traditional and old-fashioned stereo type all this time. Pesantren has a strenght in overcoming the modernisation crash by the high of adaptive, tolerant and humanis character level, which can be chategorized as an islamic liberal. It is obviously that the thought character comes from the islamic teaching with rahmatan lil alamin character. This study shows the positive response shown by shalafih madrasah toward modernity, also the ability to assert self identity at once as pesantren’s heir in the middle of the crowded of consumtive culture. Inside the resource owned by shalafih madrasah, this study fids the root of religious liberalism thought which is represented by the deep religious science, passion and desire they have to develop sience. And a point should be highlighted here is not seeing a social problem from a black and white view.
Intermittent and graded exercise effects on NK cell degranulation markers LAMP‐1/LAMP‐2 and CD8+CD38+ in chronic fatigue syndrome/myalgic encephalomyelitis
Authors: Broadbent Suzanne , Coutts Rosanne
Published: March 2017

There is substantial evidence of immune system dysfunction in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) but little is understood of exercise training effects on lymphocyte function in this illness. This study investigated whether graded and intermittent exercise improved CD8+ lymphocyte activation and natural killer cell degranulation markers compared to no exercise. Twenty‐four chronic fatigue syndrome (CFS) patients (50.2 ± 10 year) were randomized to graded exercise (GE), intermittent exercise (IE) or usual care (UC) groups; a control group (CTL) of 18 matched sedentary non‐CFS/ME participants were included for immunological variable comparisons. Main outcome measures were pre‐ and postintervention expression of CD3+CD8+CD38+ and CD3−CD16+56+CD107a+ (LAMP‐1) CD107b+ (LAMP‐2) and aerobic exercise capacity. The postintervention percentage of NK cells expressing LAMP‐1 and ‐2 was significantly higher in IE compared to UC, and higher in GE compared to UC and CTL. LAMP‐1 and LAMP‐2 expression (absolute numbers and percent positive) increased significantly pre‐to‐postintervention for both GE and IE. Preintervention, the absolute number of CD8+CD38+ cells was significantly lower in CTL compared to UC and IE. There were no significant pre‐ to postintervention changes in CD8+CD38+ expression for any group. Aerobic exercise capacity was significantly improved by GE and IE. Twelve weeks of GE and IE increased the expression of NK cell activation and degranulation markers, suggesting enhanced immunosurveillance. Low‐intensity exercise may also reduce CD8+CD38+ expression, a marker of inflammation. Both GE and IE improved exercise capacity without worsening CFS/ME symptoms, and more robust trials of these exercise modalities are warranted.
Acute effects of N‐terminal progastrin fragments on gastric acid secretion in man
Authors: Goetze Jens P. , Hansen Carsten P. , Rehfeld Jens F.
Published: March 2017

We previously identified an N‐terminal fragment of progastrin in human antrum and plasma, where it circulates in high concentrations. In this study, we examined the effects of N‐terminal progastrin fragments on gastric acid secretion by infusion in healthy individuals. Increasing doses of progastrin fragment 1‐35 were infused intravenously during constant gastric acid stimulation by gastrin‐17. In addition, the effects of progastrin fragment 1‐35, fragment 6‐35, and fragment 1‐19 on gastrin‐17 stimulated acid secretion were tested. The gastrin‐17 stimulated acid secretion decreased 30% after administration of a high dose of progastrin fragment 1‐35 (P < 0.05). In extension, a 1‐h infusion of fragment 1‐35 also decreased gastric acid output. In contrast, fragment 6‐35 did not affect acid secretion, and a single infusion of gastrin‐17 alone did not reveal fading of gastric acid output during the time course of the experiments. The results show that N‐terminal fragments of progastrin may acutely affect gastrin‐stimulated gastric acid secretion in vivo. Structure‐function analysis suggests that the N‐terminal pentapeptide of progastrin is required for the effect.
Tidal breathing parameters measured using structured light plethysmography in healthy children and those with asthma before and after bronchodilator
Authors: Hmeidi Hamzah , Motamedi‐Fakhr Shayan , Chadwick Edward , Gilchrist Francis J. , Lenney Warren , Iles Richard , Wilson Rachel C. , Alexander John
Published: March 2017

Structured light plethysmography (SLP) is a light‐based, noncontact technique that measures tidal breathing by monitoring displacements of the thoracoabdominal (TA) wall. We used SLP to measure tidal breathing parameters and their within‐subject variability (v) in 30 children aged 7–16 years with asthma and abnormal spirometry (forced expiratory volume in 1 sec [FEV1] <80% predicted) during a routine clinic appointment. As part of standard care, the reversibility of airway obstruction was assessed by repeating spirometry after administration of an inhaled bronchodilator. In this study, SLP was performed before and after bronchodilator administration, and also once in 41 age‐matched controls. In the asthma group, there was a significant increase in spirometry‐assessed mean FEV1 after administration of bronchodilator. Of all measured tidal breathing parameters, the most informative was the inspiratory to expiratory TA displacement ratio (IE50SLP, calculated as TIF50SLP/TEF50SLP, where TIF50SLP is tidal inspiratory TA displacement rate at 50% of inspiratory displacement and TEF50SLP is tidal expiratory TA displacement rate at 50% of expiratory displacement). Median (m) IE50SLP and its variability (vIE50SLP) were both higher in children with asthma (prebronchodilator) compared with healthy children (mIE50SLP: 1.53 vs. 1.22, P < 0.001; vIE50SLP: 0.63 vs. 0.47, P < 0.001). After administration of bronchodilators to the asthma group, mIE50SLP decreased from 1.53 to 1.45 (P = 0.01) and vIE50SLP decreased from 0.63 to 0.60 (P = 0.04). SLP‐measured tidal breathing parameters could differentiate between children with and without asthma and indicate a response to bronchodilator.
Potential mechanisms of effects of serum‐derived bovine immunoglobulin/protein isolate therapy in patients with diarrhea‐predominant irritable bowel syndrome
Authors: Valentin Nelson , Camilleri Michael , Carlson Paula , Harrington Sean C. , Eckert Deborah , O'Neill Jessica , Burton Duane , Chen Jun , Shaw Audrey L. , Acosta Andres
Published: March 2017

Serum‐derived bovine immunoglobulin/protein isolate (SBI), an oral nutritional therapy, is efficacious in diverse diarrheal diseases. In an open‐label study in 15 patients with irritable bowel syndrome‐diarrhea (IBS‐D), we evaluated effects of SBI (5.0 g, twice a day) for 8 weeks on safety, on bowel function and abdominal pain, tryptophan metabolism (K:T ratio), intestinal permeability (13C‐mannitol and lactulose excretion), bile acid synthesis (fasting serum FGF‐19 and C4), duodenal and stool microbiome, and the expression of 90 genes related to inflammation, immune function, and tight junctions in duodenal mucosa. Statistical analysis (paired tests, baseline vs. treatment) was based on intention to treat (ITT) principles. One of 15 Caucasian patients (13F, 2M, age 40.3 ± 2.3y, BMI 34.3 ± 3.0 kg/m2) withdrew without completing studies. There were improvements in stools/day (decrease, P < 0.001), ease of passage (P = 0.035), and evacuation (P = 0.004) with SBI therapy. Worst pain severity was numerically reduced in last 2 weeks' treatment (P = 0.078). Duodenal mucosal mRNA expression; serum C4, FGF‐19, and KT ratio; small bowel or colon permeability; and stool microbiome were not significantly different after SBI therapy, compared to baseline. In duodenal brushings, there was considerable microbiota structure difference (β diversity analysis P = 0.072, UniFrac) and, on taxonomic analysis, increased abundance of Proteobacteria Burkholderiales, Firmicutes Catonella, and unclassified genus organisms with SBI therapy. Thus, SBI therapy for 8 weeks in IBS‐D patients is associated with improved bowel function; the mechanism of benefit is unclear, though there were microbiota structure differences in duodenal brushings. Further studies in patients with low‐grade inflammation and intestinal barrier dysfunction at baseline are indicated.
Polymorphisms of α1-antitrypsin and Interleukin-6 genes and the progression of hepatic cirrhosis in patients with a hepatitis C virus infection
Authors: Motawi T , Shaker OG , Hussein RM , Houssen M
Published: March 2017

Hepatitis C virus (HCV) infection represents a serious health problem. The –174 G/C mutation in the pro inflammatory cytokine interleukin-6 (IL-6) is associated with developing liver diseases. Likewise, the S and Z mutations in the serine protease inhibitor α1-antitrypsin (A1AT) are associated with pulmonary emphysema and/or liver cirrhosis. We explored the distribution of the single nucleotide polymorphisms (SNPs) of IL-6 and A1AT genes in chronic HCV-infected patients and evaluated their impact on the progression of liver cirrhosis.

One hundred and fifty Egyptian HCV-infected patients together with 100 healthy controls were enrolled in this study. The patient groups were subdivided into chronic hepatitis patients (n = 85) and cirrhotic patients (n = 65). The SNP of IL-6 (–174 G/C, rs1800795), A1AT Z mutation (342 Glu/Lys, rs28929474) and A1AT S mutation (264 Glu/Val, rs17580) were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.

Cirrhotic patients exhibited significantly increased frequency of the A1AT S allele compared with the controls (34.6 vs. 5.0%), while the chronic hepatitis patients showed a higher frequency of the A1AT Z allele compared with the controls (14.7 vs. 2.5%). Remarkably, IL-6 (CC genotype) was detected only in the chronic hepatitis patients. Multivariate regression analysis showed that aspartate transaminase (AST) and the S alleles of A1AT, represented as SS+MS genotypes, were significantly independent predictors for development of liver cirrhosis. We concluded that inheritance of deficient S and Z alleles of the A1AT gene but not IL-6 (–174 G/C), were associated with progressive liver diseases.
Associations of biochemical changes and maternal traits with mutation 1843 (C>T) in the RYR1 gene as a common cause for porcine stress syndrome
Authors: Popovski ZT , Tanaskovska B , Miskoska-Milevska E , Andonov S , Domazetovska S
Published: March 2017

Stress syndrome is usually caused by a mutation in the ryanodine receptor gene (ryr1) and it is widely studied in humans and swine populations. The protein product of this gene plays a crucial role in the regulation of calcium transport in muscle cells. A G>T mutation in the human ryr1 gene, which results in the replacement of a conserved arginine at position 614 where a leucine occurs at the same position as the previously identified Arg→Cys mutation reported in all cases of porcine stress syndrome (PSS). Porcine stress syndrome affects biochemical pathways in stress-susceptible individuals during a stress episode and some biochemical parameters that were used as markers for diagnostic purposes. Also, PSS has remarkable influence on the maternal characteristics of sows. This study dealt with different genotypes for PSS and its association with possible biochemical changes and maternal traits of sows. Seventy-three reproductive sows genotyped for PSS by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were included in this survey. Sixty of them were stress-free (NN), 11 were heterozygous carriers (Nn) and two animals were homozygous (nn) for the 1843 (C>T) mutation. Significant differences in non stress induced animals with different PSS genotypes were found in the values of creatine phoshokinase (CPK), lactate dehydrogenase (LDH), alkaline phosphatase (AP) and aspartate aminotransferase (AST). Regarding the maternal traits, our study showed that stress susceptible animals (nn) have an increased number of stillborn piglets and a reduced number of newborn piglets compared with heterozygous and normal animals.
Customer complaints and disagreements in a multilingual business environment. A discursive-pragmatic analysis
Authors: Decock Sofie , Spiessens Anneleen
Published: March 2017

This paper probes into authentic CMC business complaints and disagreements by offering a discourse-pragmatic analysis of complaint negotiation e-mails written by French- and German-language customers. The analysis focuses on an identification and description of complaint and disagreement strategies, and on the presence of internal and external modifiers. Our data, gathered ethnographically at the sales department of a Belgian multinational, shows how the customer’s discourse evolves from more neutral, problem-oriented, routinized formulations in first complaints towards more confrontational, person-oriented, ad hoc formulations in disagreement e-mails as reactions to complaint refusals. This discursive change goes hand in hand with an increase in the use of direct speech act realizations and upgraders. As it appears, in the course of the complaint negotiation, face-threat to the speaker outweighs consideration of the addressee’s face needs. The most notable cross-cultural difference we found between German- and French-speaking customers is a more explicit style in German and a more confrontational style in French, with cross-cultural differences gaining weight at the expense of international communicative norms in less routinized messages. Finally, the results of our study urge us to reassess concepts of directness, and on a societal level, they serve to promote intercultural awareness in business contexts.
Taking metaphor studies back to the Stone Age: A reply to Xu, Zhang, and Wu (2016)
Authors: Gibbs Raymond W. , Chen Elaine
Published: March 2017

One recent trend in metaphor studies is to deny the possibility that most verbal metaphors really convey metaphoric meanings via cross-domain mappings. Instead, only a small number of verbal metaphors, those presumably produced “deliberately” and “consciously,” ever alert listeners or readers to draw cross-domain inferences. Xu, Zhang, and Wu (2016. Enlarging the scope of metaphor studies.