bluuebunny/crossref_metadata_2025 huggingface dataset:
A review of prognostic biomarkers in uveal melanomas
Authors: Kashyap Akriti , Tripathi Preeti , Sen Arijit
Published: August 2020

Prognostication of uveal melanomas (UM) has evolved from basic histopathological factors like tumour size, location and cell morphology to more sophisticated methods like counting chromosomal gains and losses which can be detected using FISH analysis and karyotyping. A number of driver mutations have been discovered which allow testing of response to targeted therapies. GNAQ and GNA11 mutations are early events while BAP1, SF3B1 and EIF1AX mutations occur later. Gene expression profiling is a highly accurate and informative standard for molecular prognostication. In addition, since UM spreads hematogenously, therefore, blood biomarkers may be helpful for monitoring the disease progression. Thus, understanding the prognostic significance of these mutations and blood biomarkers could facilitate their use in precision medicine
Closure of small perforation in tympanic membrane by use of fat plug
Authors: Patel Nehal R. , Patel Vaibhav V. , Padavi Dimpal , Prajapati Mayur , Khokhani Rachana M. , Sharma Pooja A.
Published: August 2020

Background: Chronic suppurative otitis media presents mostly with ear discharge and associated decreased hearing. Tympanoplasty is the established surgery for tympanic membrane perforation. Most commonly used graft material for tympanoplasty is temporalis fascia. Others are fascia lata, tragal perichondrium, tragal cartilage, fat. The objective of the study was to compare the graft taken up and hearing improvement following myringoplasty with use of fat.

Methods: Patients of CSOM aged 10 to 65 years old with small central perforation which is dry for at least 3 weeks with normal middle ear mucosa and intact ossicular chain with mild conductive hearing loss. The present study was carried out in Ear, neck and throat (ENT) Department of SCL hospital, Ahmedabad from July 2016 till September 2018 and 25 patients were randomly selected fulfilling the above criteria.

Result: The choice of graft affects not only the outcome of surgery, but also determines the complexity of the procedure and the time taken for the same. Study proves that fat is also a one of the good grafting material which is easily available and keep to prevent from major surgery. The results have been quite encouraging.

Conclusion: Study proves that fat is also a one of the good grafting material which is easily available and keep to prevent from major surgery. An added advantage of this technique was the excellent post-operative quality of life of the operated patients, assessed in terms of the chronic ear survey and evident by the absence of the usual post-operative complaints following a conventional myringoplasty.
Role of narrow band imaging in the detection of mucosal lesions of head and neck
Authors: Bhandari Pranay , Sachdeva Kavita
Published: August 2020

Background: Head and neck mucosal lesions are difficult to diagnose at early stage; therefore, they usually present at an advance phase. Narrow Band imaging (NBI) first came to use around 2005 and became one of the most used technologies for image enhanced endoscopy.

Material and method: In order to identify best method for early detection of mucosal lesion of head and neck, we examined patients with suspected lesions first under white light endoscopy then under NBI endoscopy. Patients under-went biopsy thereafter, and results were compared. Our aim was to evaluate the role of NBI as a screening tool in the early detection of mucosal lesions of head and neck.

Result: It was observed that NBI is useful tool in identifying mucosal lesions of head and neck early. 71 patients were included in our study and it was observed that NBI endoscopy shows 100% sensitivity, 96.36% specificity and 97.18% accuracy in identifying benign lesions. It shows 100% sensitivity, 94.74% specificity and 98.59% accuracy in identifying malignant lesions.

Conclusion: In our study we came to conclusion that NBI is very promising tool for early screening purposes of mucosal lesions of head and neck which were missed in routine examination.
Superior laryngeal nerve dysfunction following thyroid surgery: assessment of incidence and long-term effect
Authors: Dubey Ravindra , Raj Poonam
Published: August 2020

Background: Importance of Sentinel lymph node (SLN) in thyroid surgery has received little attention compared to Recurrent laryngeal nerve (RLN). Injury to the external branch of the superior laryngeal nerve (EBSLN) is a voice-altering complication of thyroid surgery that has significant implications for professional voice users. The symptoms can be nonspecific and the subtle laryngoscopic manifestations are often overlooked.

Methods: This study involved 50 patients of thyroid disease with no prior voice pathology who subsequently underwent thyroid surgery. All patients underwent voice analysis pre-operatively, including video laryngoscopy, voice analysis and Grade of hoarseness, roughness, breathiness, asthenia, and strain (GRBAS) scale. Voice analysis was repeated at 2 weeks, 4 weeks, 3 months and 6 months post operatively. Patients with no change in voice after 04 weeks were not followed up subsequently.

Results: Of 50 patients, 20 (40%) patients underwent hemithyroidectomy, 18 (36%) total thyroidectomy, 11 (22%) subtotal thyroidectomy and 1 (2%) Near total thyroidectomy. Based on voice analysis, patients were categorized into four different groups namely - normal with no laryngeal nerve injury (N=45, 90%), RLN palsy (N=2, 4%), SLN palsy (N=3, 6%). Patients with SLN palsy showed bowing of vocal cords persisting till 06 months post operatively. There were changes in fundamental frequency also, which appeared at 02 weeks and gradually improved on subsequent follow up.

Conclusions: The prevalence of SLN injury and dysfunction is unknown as many cases go undiagnosed. Further research is needed to improve the index of suspicion in patients with poor voice quality and reduced vocal range post operatively. On improved diagnostic accuracy, early treatment of this complex disorder may lead to significant recovery.
Reconstruction of scalp with local axial flaps
Authors: Srivastava Saket , Gupta Pradeep
Published: August 2020

Background: The scalp is a unique part of the human body and various etiological factors, such as tumour extirpation, infection, burns, or trauma, can lead to scalp defects. Primary closure, skin grafting, local flaps, tissue expansion or free tissue transfer are modalities available for scalp reconstruction. In this article, the authors share their institutional experience using various local flaps concerning the size, location, depth of defect and the quality of surrounding tissue.

Methods: From September 2017 to January 2020, 54 patients underwent scalp reconstruction with local flaps for a defect size of 5 to 150 cm2 in the department of plastic surgery, SMS medical college, Jaipur. Patients were identified by age, sex, cause of the scalp defect; the location, size, and depth of the defect; condition of surrounding tissue and the type of reconstruction done.

Results: The most common cause of scalp defect was excision of malignant tumour (50%). Thirty patients had a large sized defect (40-90 cm2) and 28 patients had 90-150 cm2 defects. Surgical reconstruction was done using local flaps, transposition flap was the most used in 36 patients (66.7%) followed by rotation advancement flap in 11 patients (20.4%). The recovery was relatively quick. Minor complications happened in 5 patients (9.3%) that were managed conservatively.

Conclusions: In the present era of microsurgical reconstruction, local options as axial flaps provide a simpler and safer method of scalp reconstruction. A carefully planned scalp flap gives healthy, robust, hair-bearing tissue coverage and requires a shorter healing time for the patients.
Safety precautions for otorhinolaryngologists during the COVID-19 pandemic
Authors: Sahoo Soumick Ranjan
Published: August 2020

As COVID rapidly spreads through respiratory droplets, health care workers who perform aerosol generating diagnostic and therapeutic procedures, such as otolaryngologists–head and neck surgeons, are particularly at risk. In the article guidelines regarding attending a patient in ENT OPD and emergency, endoscopy examination, taking biopsy, operation theatre (OT) setting and precautions and guidelines to be followed while doing ENT and head and neck operations have been discussed based on review of literature.
Asymptomatic COVID-19 patients: a threat to an active otolaryngologist
Authors: Nagi Ravinder Singh , Singh Satinder Pal , Duggal Prahlad
Published: August 2020

A new virus was reported for causing a spurt of pneumonia cases in Wuhan, Hubei 56 province in China in December 2019. This coronavirus, was initially named as the 2019- novel coronavirus (2019-nCoV) on 12 January 2020 by World Health Organization (WHO). WHO officially named the disease as coronavirus disease 2019 (COVID- 19) and coronavirus study group (CSG) of the International Committee proposed to name the new Coronavirus as SARS-CoV-2, both issued on 11 February 2020.
All polyethylene tibia - results of functional and radiological outcome at 5 years follow-up
Authors: Patel Digen , Shah Kunal Ajitkumar , Desai Mohan Madhav , Shah Swapneel S.
Published: August 2020

Background: Earlier, all-polyethylene tibial (APT) components were the only option available for TKA. APT components improved over years and have shown results similar or superior to MBT components with respect to survivorship and rate of complications. This study aimed to assess the functional and radiological outcome of TKA with APT components with 5 years follow-up.

Methods: This longitudinal study was conducted in a tertiary care center in Mumbai in year 2018. All patients who underwent TKA with APT components during the year 2012 were included in the study. Total of 147 knees were operated in 120 patients. Ninty patients (111 knees) followed up at 5 years. Preoperative and postoperative assessment of patients was done for function, pain and radiological outcome. Functional scores used were Knee society score, WOMAC osteoarthritis index, Bristol score and Oxford knee score. Visual analogue scale (VAS) score was used for pain assessment. Pre and postoperative X-rays were done and component alignment angles (α, β, γ and δ) were calculated.

Results: Statistically significant difference was found in pre and postoperative values of VAS score, knee society score, WOMAC osteoarthritis index, Bristol score and Oxford knee score (p value <0.001). Component alignment angles were found to be same pre and postoperatively. None of the patients had radiologic evidence of loosening of implants.

Conclusions: APT components have good to excellent functional outcome and good radiological outcome at 5 years. They are safe in view of radiologic component migration at 5-year follow-up.
Rising incidence of hip fractures in Sindhudurg west coast of Maharashtra, South India (2000 to 2011)
Authors: Kulkarni Raghavendra S. , Kulkarni Aditya P. , Kulkarni Rachana A. , Kulkarni Ranjani R. , Deshpande R. S. , Kulkarni Sriram R.
Published: August 2020

Background: The incidence of hip fractures in Sindhudurg, west coast of Maharashtra has been reported in relation to age and gender.

Methods: Using the medical records and X-ray registers from May 2000 to October 2011, all patients of proximal femoral fractures were recorded and included in this study. The data was cross checked doubly with details of indoor case papers against ward admission and operation theatre registers, were found to be congruent after verifying the names of patients.

Results: The total male incidence was bimodal with moderate peaks at 31 to 50 years and very high at 51 to 70 years. The female incidence with peaks at 41 to 60 years with regular steady increase up to 80 years. Males of 31 to 70 years 2.5 times more likely to sustain a fracture (95% CI 2.3 to 2.8) than females. Females between 40 to 60 years 2.8 times more likely to sustain fracture than males (95% CI 2.5 to 3.0). The trend was stable from year to year. This high increase in hip fractures in men of 51 to 70 years incidence documented osteoporotic fractures in contrast with too much emphasis on the importance of menopause in hip fractures.

Conclusions: Despite wide variations in age specific hip fracture rates over a decade, reasons for differences are not clear. From 2000 to 2011, the hip fractures in district hospital increased by a factor of 6.6%, 14.34% in both the genders above the age of 41 years in parallel with hospital admissions.

 
Role of bone marrow infiltration in management of delayed union of long bones fracture
Authors: Meena Sanjay Kumar , Goyal Naveen , Tetarwal Devendra , Sharma Bharat
Published: August 2020

Background: Usually delayed union of fracture long bones are managed by putting a bone graft at fracture site , but bone grafting have donor site complication like scar, infection ,hernia ,gait disturbance , cosmetic problem, as well as recipient site complication like soft tissue trauma , de-vascularisation of fracture fragment. Bone marrow infiltration is a minimally invasive method done percutaneously. It is easy, safe procedure with no associated complications that may occur in bone grafting.

Methods: This prospective study was conducted in the Department of orthopedics, Government Medical College, Kota from June 2011 to November 2013 to evaluate the efficacy of percutaneous bone marrow infiltration in cases of delayed union of long bones. 27 patients included in study with 28 bones, as one patient has given bone marrow injection in two bones (tibia & femur), so the cases included in study counted as 28 cases. The mean age of this study was 38.28 years, ranging from 18 years to 75 years.  All cases were follow up after 4 to 6 weeks and thereafter one month interval. Final follow up was taken when fracture site shows clinical and radiological sign of union.

Results: Out of 23 united cases 19 had excellent results and 04 cases had good results. The five cases which fail to unite were taken as poor results.

Conclusions: Bone marrow infiltration is a minimally invasive, safe bone graft substitute for delayed union of long bones and have less complications.
SPARSH: a camp based approach for orthopaedic disabilities and its success in central India
Authors: Singhal Prakhar , Mishra Santosh Kumar , Shukla Jiten , Verma Rahul , Gohiya Ashish
Published: August 2020

Background: Around 15% of population in the world is living with disability. The present study was carried out during the special project for assistance, rehabilitation and strengthening of handicapped (SPARSH) camp to know the current pattern of locomotor disability and to observe the outcome of the camp surgeries for the correction of deformity.

Methods: This prospective observational cross-sectional study was conducted at the department of orthopaedics and traumatology Gandhi Medical College at SPARSH camp organised by the Government of M. P. at J. K. hospital Bhopal. All the patients with locomotor disability attending the SPARSH camp irrespective of age, sex and cause, were included in the study

Results: In total 287 patients attended the camp in which majority of the patients were suffering from cerebral palsy. 107 patients were selected for operative intervention in which tendo-achilles lengthening was performed most commonly.

Conclusions: The corrective surgical camp provides an avenue of healthcare opportunity for the underprivileged sector of society. A camp based approach helps in identification, gradation & rehabilitation of orthopaedic deformities.
Post-operative complications of displaced unstable distal end radius fracture treated by volar plating
Authors: Ambulgekar Rajesh K. , Gurnani Vishal
Published: August 2020

Background: Fracture of the distal radius (DRF) is one of the most common fractures present in emergency. The most common operative treatments of these fractures are open reduction and internal fixation with volar locking plates. The incidents and types of complications associated with the use of these operations is an ongoing process till date. The objective of the study was to find demographic profile of patients of displaced unstable distal end radius fracture, and to study the post-operative complications among above patients treated by volar plating.

Methods: We performed a prospective study documenting types of complications and their occurrence in a group of patients who received open reduction and internal fixation. Our definition of a complication was a case in which the patient had one or more complications which required an intervention medical or surgical.

Results: A total of 33 patients were included, most of the cases, (63.63%) were from the age group 21-40 years. We had 4 cases (12. 12%) females, and 29 cases (87.88%) males. Post-operative complications were noted in 7 individuals 22.2 % and no complications noted in 26 cases (78.8%). In 30 cases there was no any deformity found in postoperative one year follow up, 2 patients develop prominent ulnar styloid found in follow up of one year ,and 1 residual dorsal tilt found after one year.

Conclusions: Our finding that 22.2% suffer from complication when treated using a volar locking plate must be taken into consideration when surgeons choose between conservative or operative treatment for DRF treatment. A few other studies have looked at the incidents of complications and have reported similar results.
Efficacy of proximal femoral nail augmentation in unstable intertrochanteric fracture
Authors: J. Purushotham V. , Khan M. Ayyub , Kumar Navneeth
Published: August 2020

Background: To assess the short term functional and radiological outcome of unstable intertrochanteric fracture fixation using proximal femoral nail with augmentation using Cannulated Cancellous (CC) screw or Stainless Steel (SS) wiring.

Methods: A prospective study was conducted with 20 cases of unstable intertrochanteric femoral fractures from May 2017 to March 2019. Six females and fourteen male patients in the age group between 40 and 80 years were included in this study. There were 8 cases of AO31A2 and 12 cases of AO31 A3. Fracture were fixed by proximal femoral nail with augmentation by an additional CC screw or encirclage with SS wires to strengthen the lateral trochanteric wall.

Results: Fracture union was achieved in all cases with a mean period of 15.4 weeks. Patients were followed up for a period of 6 months. At the end of follow up the Modified Harris Hip Score was found to be more than 90 % in 16 cases.

Conclusion: Augmentation of proximal femoral nail in unstable intertrochanteric fracture with additional screw or cerclage wire increases the efficacy and stability of construct, aiding union and expedition of time to union.
Comparative evaluation of management of intertrochanteric fracture femur with proximal femoral nailing versus dynamic hip screw
Authors: Adhikari Navneet , Shekhar Chandra , Singh Ganesh , Singh Hardev
Published: August 2020

Background: Fractures involving trochanteric region of femur are one of the common fractures affecting elderly population. Presently surgical treatment is the treatment of choice with early mobilisation as primary goal. The two most common implants that are used are Dynamic hip screw (DHS) and Proximal femoral nail (PFN).

Methods: This was a prospective study with 50 patients divided randomly into two groups of 25 each. One group operated by PFN and other with DHS. Patients were evaluated periodically and final comparison between two group was done at six months for analysing results on the basis of Harris hip score.

Results: At final follow up in patients in PFN group 9 (36%), 7 (28%), 5 (20%), 4 (16%) patients had functional grade in excellent, good, fair and poor category respectively. In DHS group patients, 7 (28%), 10 (40%), 6 (24%), 2 (8%) patients had functional grade in excellent, good, fair and poor functional grade. Harris hip score was insignificantly (p>0.05) lower in patients of PFN (82.68±12.28) than DHS (84.60±10.39).

Conclusion: At final follow up we found that pain, limp, use of support while walking and hospital stay was less in PFN group. However, range of motion and hip functions were better in patients treated with DHS. Complications like Varus malunion and infection were common in DHS group while hip joint stiffness was seen more commonly in PFN group. So, both PFN and DHS in are comparable in respect to most of functional criteria for treatment of intertrochanteric fracture femur.
A study on epidemiology of foot injuries in South Indian population at a tertiary care centre
Authors: Balaji Gopisankar , Nema Sandeep , Kumar Anand
Published: August 2020

Background: Knowledge of the epidemiology of foot injuries might be useful for implementing injury prevention programmes and for academic research purpose.

Methods: This retrospective descriptive study was conducted on patients presenting with foot injuries to our emergency medical service department from May 2018 to April 2019.

Results: Total 604 foot injuries were available for final evaluation. There were 461 male and 131 female patients. The mean age was 32.09 years.  The commonest mode of injury was road traffic accident. Total 192 feet had only soft tissue injuries while 412 had bony injuries. Total 140 of 323 cases of forefoot injuries were due to metatarsal fractures followed by 63 cases of proximal phalanx fractures. Among the midfoot injuries, Lisfranc fracture dislocation was more common accounting for 12 out of 38 cases. Calcaneal fractures were more common among hindfoot injuries accounting for 27 out of 45 cases.

Conclusions: To conclude, foot injuries account for 13.4% of all musculoskeletal injuries. 68.2% accounts for bony injuries. Among foot bony injuries, forefoot injuries (78.4%) are more common.
Care seeking interval - an indirect measure of sexually transmitted infections related stigma: a prospective observational study
Authors: Sikkanthar Syed Iqbal , Stephen Anitha Christy , Shanmugasundaram Sakthivadivu , A. Kayalvizhi V.
Published: August 2020

Background: Stigma about STDs (sexually transmitted diseases) may influence an individual’s decision to disclose information about his/her sexual behaviour to health care practitioners as well as to their sex partners. This leads to a continued transmission of sexually transmitted infections (STI) and greater probability of adverse sequelae. Thus, care seeking interval may be regarded as an indirect measure of stigma associated with STI. The aim of this study is to assess healthcare-seeking behaviour of patients and the factors associated with its delay.

Methods: This was a cross-sectional study conducted over a period of 1 year in STD OP of Government Stanley medical college, Chennai which included all symptomatic STD Patients who came to OP. The data were collected using a semi-structured questionnaire. The statistical package SPSS (version 16) was used for analysis.

Results: The study included 492 males and 517 females who presented with STD related symptoms. Nearly 54% of patients sought care after 7 days of onset of symptoms. In that 52% of patients reported their delay to be due to fear of disclosure about their symptoms, 19% had self treatment, 12% of them expected spontaneous resolution, 8% had lack of awareness about their symptoms and the remaining 9% reported various other causes.

Conclusions: Fear of stigmatisation has a positive association with increased care seeking interval in STDs. Addressing concerns about stigma and educating the public about timely heath care could help reduce the complications of STDs among high risk adult population thereby improving the quality of patient’s life.
A study of intradermal tranexamic acid for treatment in melasma patients
Authors: Samanthula Haritha , Koganti Manaswitha , Chowdary Neethu , Kurapati Aruna Sree
Published: August 2020

Background: Melasma is a common acquired pigmentary dermatosis due to a disorder in the melanogenesis process. Although several treatments are currently used, it remains a great challenge. It was recently reported that intradermal tranexamic acid (TA- plasmin inhibitor) is an effective treatment for melasma. Aims of the study were to assess the efficacy and side-effects of localized microinjection of TA for the treatment of melasma.

Methods: A total of 30 patients with melasma, who did not respond to topical therapy were included in the study, after taking informed consent. The severity and extent of pigmentation was assessed by modified melasma area severity index (MASI). Patients were then administered localized microinjections (10 mg/ml) of TA weekly for 6 weeks. The response to treatment was assessed by MASI and clinical photographs at each session and after 3 months of stopping treatment.

Results: Among 30 patients significant decrease in the MASI from baseline was observed. 36.6% patients showed >75% improvement, 43.3% showed 50-75% improvement, 6.8% showed 30-49% improvement, and 13.3% showed <30% improvement at the end of 6 weeks. Side effects were minimal, and all the patients tolerated the treatment well. At 12 weeks 32% of patients developed mild recurrences and the rest of the patients maintained the same MASI.

Conclusion: Based on our results, intradermal TA (10 mg/ml) can be used as potentially new, effective and safe treatment for melasma.
A study on safety and efficacy of intralesional vitamin D3 in cutaneous warts
Authors: Potlapati Amruthavalli , Gangaiah Narendra , George Neethu Mary
Published: August 2020

Background: Immunotherapy is an upcoming treatment modality for cutaneous warts. Majority of the treatment modalities used for warts are destructive and can be painful, causes scarring and are not suitable for multiple warts. Immunotherapy overcome these shortcomings and it has shown good response both in injected and distant warts. Literature shows only very limited data on the use of immunotherapy, especially vitamin D3, in case of cutaneous warts. Objective was to evaluate the safety and efficacy of intralesional vitamin D3 in cutaneous warts and to assess the treatment response and adverse effects of the same.

Methods: Sixty patients of age more than 18 years of both sexes with cutaneous warts were given intralesional vitamin D3 of maximum five doses two weeks apart after obtaining an informed written consent. Patients were monitored for reduction in size and number of warts and also for any side effects.

Results: Out of the total 60 patients, 46 (76.6%) patients had complete resolution of warts following injection, 12 (20%) cases showed partial response and 2 (3.4%) cases had no response.

Conclusions: Intralesional vitamin D3 was found to be an effective treatment modality for multiple and recalcitrant warts.
A cross sectional study to investigate the prevalence of metabolic syndrome in clinically diagnosed patients of psoriasis vulgaris in South Gujarat
Authors: Gundavda Pankti Manit , Patil Priyanka Chandrakant , Umrigar Dipak D.
Published: August 2020

Background: Psoriasis is a common, chronic, inflammatory keratinization disorder of the skin. It can be triggered by many environmental as well as genetic factors.  The metabolic syndrome (syndrome X, insulin resistance syndrome) consists of a constellation of metabolic abnormalities that confer increased risk of cardiovascular disease (CVD) and diabetes mellitus (DM). Often coexistence is noticed between psoriasis and metabolic syndrome.

Methods: A cross-sectional study was conducted in the Government medical college and new civil hospital, Surat. A total of 115 clinically diagnosed cases of psoriasis vulgaris and similar age and sex matched controls visiting dermatology out patients’ department of new civil hospital, Surat were selected for the study.

Results: Prevalence of metabolic syndrome is significantly higher in psoriatic patients after the age of 40 years, and it directly correlates to psoriasis duration. No association observed with gender, percentage of body surface area involved and smoking, but in patients of 18-40 years with metabolic syndrome had significantly higher percentage of body surface area involved as compared to >40 years age group.

Patients with metabolic syndrome had mean disease duration of 5.52±5.83 years and BMI was 27.48±4.36.

Conclusions: Higher prevalence of metabolic syndrome in patients with psoriasis could play a relevant role in accelerating atherosclerosis. All patients with psoriasis should be encouraged to aggressively correct their modifiable cardiovascular risk factors.
Familial diffuse comedones, different entity or variant of familial dyskeratotic comedones: a case report
Authors: Thokchom Nandakishore , Kongbam Linda , Bhattacharjee Nandita , Salam Erika
Published: August 2020

Familial dyskeratotic comedones(FDC) is a rare autosomal dominant genodermatosis characterized by numerous comedones with dyskeratosis in histology. We report a case of 43-year-old woman and her 16-year-old daughter presenting with extensive diffuse comedones on the face, trunk and proximal extremities. Mild slate-grey pigmentation of face in the mother was an additional finding. Skin biopsy showed crateriform invagination with parakeratotic lamellae filled with keratinous material in the epidermis but no dyskeratosis or acantholysis. The case resembles FDC as described earlier. However, certain features like presence of hyperpigmentation and minimal hyperkeratotic papules, and absence of dyskeratosis or acantholysis may suggest that diffuse familial comedones exist as a different genodermatosis.
Detection of a pheomelanin-like pigment by EPR spectroscopy in the mycelium of Plenodomus biglobosus
Authors: Pukalski Jan , Marcol Natalia , Wolan Norbert , Płonka Przemysław Mieszko , Ryszka Przemysław , Kowalski Tadeusz , Latowski Dariusz
Published: August 2020

Melanin occurrence in Plenodomus biglobosus was investigated using electron paramagnetic (spin) resonance (EPR, ESR) spectroscopy. The fungus was isolated from living and dead leaves of European ash (Fraxinus excelsior L.). Dark pigmentation of P. biglobosus mycelium in vitro, especially on the reverse, was observed. The black coloration intensified with the age of the culture and inspired us to check if the analyzed fungus species synthesizes melanin. Melanin contains unpaired electrons, thus, EPR spectroscopy was applied, as a specific technique, to verify its presence in P. biglobosus. The EPR spectrum of the mycelium showed a very strong melanin signal, revealing pheomelanin-like features. Thus, the black pigment of P. biglobosus was clearly identified as melanin. However, no melanin was detected in the apparently dark culture medium even when zinc (II) acetate was added to increase the sensitivity of detection. Pheomelanin has many unusual biological functions but it is not commonly found in fungi. Detection of this type of melanin in P. biglobosus, which can be both endophytic or pathogenic, suggests a closer examination of the potential role of this melanin in host-parasite interaction.
EDUCAÇÃO EM SAÚDE COMO ESTRATÉGIA DE QUALIFICAÇÃO DA ASSISTÊNCIA ÀS GESTANTES NO INTERIOR DO CEARÁ
Authors: Albuquerque Brandão Maria Girlane Sousa , Rocha Sibele Pontes , Pedroza Cavalcante Ana Suelen , Carneiro Bezerra Maria Amélia , Osawa Vasconcelos Maristela Inês
Published: August 2020

Objetivo: relatar a experiência de ações de educação em saúde, utilizando o Círculo de Cultura de Paulo Freire com um grupo de gestantes. Método: trata-se de um relato de experiência desenvolvido com um grupo de gestantes em um em um Centro de Saúde da Família do município de Sobral, Ceará. Resultados: foram desenvolvidos dez encontros de intervenção observando as necessidades das gestantes, tais como: autoestima, paternagem, direitos trabalhistas, sexualidade, exercícios físicos e outros. As ações de intervenção contaram com o apoio da enfermeira da unidade de saúde, bem como da equipe de residentes do Programa de Residência Multiprofissional em Saúde da Família. Considerações Finais: A vivência relatada propiciou uma troca de saberes entre acadêmica, equipe de saúde da família e gestantes, agregando melhorias ao processo de educação em saúde, baseado na construção compartilhada de conhecimentos, ampliando o espaço universitário e exercitando o compromisso social da Universidade.
Morphobiological features and productivity of artichoke in the conditions of Southern Uzbekistan
Authors: Aramov M. N. , Aliyev B. N.
Published: August 2020

Relevanc and methods.The article presents the research results on the introduction of artichoke in Uzbekistan. In the process of research, some issues of artichoke seed production in the conditions of dry subtropics of Uzbekistan were also studied. Studies were carried out on the Krasavets cultivar. When identifying the most effective method for forming a seed bush, the comparison of growing seed plants without formation and 4 methods of formation was compared: 1 stalk on a plant and 3 inflorescences on a stalk, 2 stems on a plant and three inflorescences on each, 3 stems on a plant and three inflorescences on each, 4 stems on the plant and three inflorescences on each.

Results.It was revealed that artichoke plants grow and develop, form full-fledged seeds during the growing season. The manifestation of morphobiological and economically valuable traits largely depends on the age of the plants. A significant reduction in the growing season, an increase in the height of plants and the number of stems, an increase in the average mass and number of inflorescences and, ultimately, yield occurs in the second year of plant life. It was also revealed that the potential productivity of artichoke plants in Uzbekistan is very high. The yield of the Krasavets cultivar in the second year of life is 55.5 t/ha, and that of the Green Globe cultivar is 39.2 t/ha. This is significantly higher than the global average. The highest seed productivity was noted in the variant without the formation of a seed plant: 734.2 g/plant or 15789 seeds/plant. However, in such indicators as the mass and number of seeds from one inflorescence, the mass of 1000 seeds of a plant without formation is significantly inferior to other options. Based on the results of experiment 3, 4, 5, the options can be considered appropriate to use in artichoke seed production.
Optimal nutritional area for garlic seed plants
Authors: Salomov B. S. , Aramov M. H. , Ramazonov T. T. , Normuminov I. M.
Published: August 2020

Relevance. A large number of forms and varieties of garlic created in the selection process allowed this culture to spread almost all over the world: in temperate regions, in subtropics and even in tropical regions. Currently, the world's acreage of garlic is 1.438 million hectares, the average yield is 16.9 tons per hectare, the gross yield is 24.255 million tons. The largest producers of garlic are China, India, South Korea and Egypt. The highest yield was recorded in Uzbekistan, Egypt, China, Tadjikistan. In Uzbekistan, it is grown everywhere, mainly on household plots and small areas in farms. In the republic, varieties of garlic are South-violet (1972) and May VIR (1978).

Material and methods. Since 2004, the Surkhandarya Scientific Experimental Station of the Vegetable Melon Crops and Potato Research Institute has been conducting selection work to create new varieties of garlic. As a result of the research, the Chidamli variety was introduced and, since 2016, introduced into the State Register. All zoned varieties belong to the group of autumn-sprouting varieties. The purpose of this research is to determine the optimal nutritional area for seed plants of garlic in elite seed production. The object of research was the garlic variety Chidamli.

Results. During organization of elite seed рroduction, planting of clovers on pattern (40+15+15) x l0 sm, (40+10+10+10) x l0 sm was considered acceptable. Big and qualitatative bulbs and clovers were got bu this planting pattern. Yielding capacity was 24,4-26,2 t/ha, average weight of bulbs 63-66 g, clovers number 13,0 pcs., average weight of clovers 4,5-4,7 g.
Determination of bean resistance to anthracnose pathogen – Colletotrichum lindemuthianum Br. et Cav
Authors: Pashkevich A. M. , Tchaikovsky A. I. , Medved N. V.
Published: August 2020

Relevance. Currently, the range of vegetable crops has firmly entered the bean, the protein of which is absorbed by the human body by 87% or higher. The main factor limiting the cultivation of beans in Belarus is the lack of varieties of this crop that are resistant to mycological diseases, primarily Anthracnose.

Materials and methods.The study included 34 samples of vegetable beans of mutant and hybrid origin obtained in the sector of legumes of vegetable crops of RUP "Institute of vegetable growing of the National Academy of Sciences of Belarus". To obtain a mutagenic effect, induced mutagenesis was used in the form of the action of a radioactive isotope 60Со and a neodymium laser. Hybrid combinations were obtained by intraspecific hybridization of mutant samples. For molecular genome testing, DNA was isolated from plant leaves before flowering, and its purification was performed by Fermentas using a Genomic DNA Purification Kit. The concentration of the resulting DNA solution was determined by a spectrophotometric method on a CARY 50 SCAN. A Thermo Hybaid RX2 amplifier was used for PCR. The annealing temperature of the primer was determined using the program "oligocalculator". The CV 2014 primer was used as a marker. resistant genotypes to Colletotrichum lindemuthianum Br. et Cav were at the band level of about 450 BP. Phytopathological assessment of plant infectivity was carried out on the basis of visual and instrumental methods, taking into account the reaction of plants and the intensity of the lesion, in the conditions of a natural infectious background in the phase of technical ripeness.

Results. Seven samples of beans were identified that have genetic resistance to Anthracnose and show it in the conditions of a natural infectious background.
“Finishing One Big Adventure in Order to Embark on Another”: Exploring University Research Blogs
Authors: Tomášková Renáta
Published: August 2020

The article focuses on blogs related to research activities of the academic community. Research-related blogs as components of university websites have developed into an array of sub-genres shaped by specific foci, their authors and the desired audiences. The data set consists of fifty posts from ten blogs of six universities. Drawing upon Swales’ methodology of genre analysis, the study explores the generic structure of the blog posts, reveals the communicative purposes they can fulfil within the landscape of university websites, identifies significant communication strategies, and explores the roles the blogs may serve in communicating science to the diverse audiences they potentially address. The analysis has shown that the blogs help accomplish the general goals of informing about the university and promoting it providing a personalized view and engaging the reader, manifest loose but recurrent generic structuring, and can be vehicles of knowledge dissemination as well as knowledge construction.
GeoGebra en 2D y 3D como recurso didáctico en un curso de integración múltiple: una experiencia de enseñanza-aprendizaje
Authors: Ramírez Santamaría Bolívar Alonso
Published: August 2020

El presente artículo tiene como finalidad exponer una experiencia de enseñanzaaprendizaje sobre el uso de GeoGebra, en dos y tres dimensiones, como un recurso didáctico para estudiar temas relacionados con integración múltiple. Para ello, se usó este software educativo en las clases y actividades de evaluación en un grupo del curso Principios de Análisis II, de la carrera de Bachillerato y Licenciatura de la Enseñanza de la Matemática, de la Sede Occidente de la Universidad de Costa Rica. Se utilizaron diferentes técnicas de recolección de información como exámenes parciales, cuestionarios y guías de observación. Se llega a la conclusión principal de que el uso de GeoGebra realmente promueve la motivación y la comprensión de los educandos en el estudio de temas sobre integración en varias variables.
Uso de recursos digitales por profesores de matemáticas en secundaria: un estudio exploratorio
Authors: Inzunza Cazares Santiago , Ward Bringas Silvia E. , Palazuelos Ordoñes José L.
Published: August 2020

Se presentan resultados de una investigación sobre uso de recursos digitales por profesores de matemáticas de secundaria mexicanos. Una muestra de 81 profesores de 24 escuelas secundarias fue seleccionada para responder un cuestionario y entrevistas para explorar las formas de uso y selección de los recursos, las interacciones que los profesores establecen con los recursos, además de factores institucionales y creencias que determinan su uso. Los resultados muestran una escasa formación y actualización de los profesores en el uso de recursos digitales, atribuible en parte a condiciones institucionales, pero también a creencias y actitudes de los profesores hacia la tecnología, se observó un bajo nivel de integración de los recursos digitales en el proceso de enseñanza, principalmente con actividades centradas en la transmisión de contenidos.
OS RASTROS DO HIGIENISMO EM ALAGOAS: REFLEXÕES SOBRE O JORNAL DE ALAGOAS (1939)
Authors: Santos Fernanda Lays da Silva , Amorim Roseane Maria de
Published: August 2020

Analisam-se os vestígios do movimento escolanovista e higienista em Alagoas e suas implicações no currículo escolar. Este trabalho faz parte de uma pesquisarealizada no campo do currículo e da História da educação. Tem-se como objetivo investigar como as relações de poder se estabeleceram no âmbito escolar; analisar o discurso de Arthur Ramos e sua influência na construção do currículo escolar em Alagoas. Um dos instrumentos de análise foi o Jornal de Alagoas (1939) que circulou no estado com seções escritas pelo higienista Arthur Ramos destinando orientações à educação familiar e escolar da classe popular. No campo da historiografia, utiliza-se a perspectiva da Escola dos Analles, a Nova História Cultural, por compreender ser função do historiador pesquisar e recuperar histórias e personagens tidos como invisíveis. Esta é uma pesquisa de caráter documental e bibliográfico. Constata-se que Arthur Ramos influenciou no constructo do currículo escolanovista divulgando essas ideias no Jornal de Alagoas (1939), sendo esse um meio de circulação destinado também à educação escolar e à população em geral.
Aksu Ovasında Farklı Flüviyal Depozitler Üzerinde Gelişen Toprakların Özelliklerinin ve Dağılımlarının Belirlenmesi
Authors: ALTUNBAŞ Sevda , GÖZÜKARA Gafur , DEMİREL Bayram Çağdaş
Published: August 2020

Amaç: Bu çalışmanın amacı, alüviyal depozitler
üzerinde gelişen toprakların morfolojik, fiziksel ve kimyasal özelliklerinin
tespit edilmesidir.

Materyal ve Metot: Araştırma kapsamında alüviyal depozitler
üzerinde gelişen dokuz pedon tanımlanmıştır. Arazi şartlarında seri düzeyinde morfolojik tanımlamaları
yapılan toprak profillerinden, genetik horizon esasına göre toplamda 45 adet
bozulmuş toprak örneği alınmıştır.

Bulgular: Çalışma alanında taşkın düzlüğü, nehir sırtı
ve yan dere aluviyalleri olmak üzere üç farklı fizyografik ünite ve bu
fizyoğrafyalar üzerinde yayılım gösteren dokuz farklı toprak serisi tespit
edilmiştir. Tespit edilen toprak serileri; Taşkın düzlüğünde: İçme suyu serisi,
Nehir sırtı alüvyalleri üzerinde: Tepeönü, Tepelik ve Çakıllı serileri ve Yan
dere alüviyalleri üzerinde: Desteiçi, Köseler, Fettanlar, Yeşilyurt ve Domuz
Tepesi serileri olarak isimlendirilmiştir. Çalışma alanı topraklarının genç
olması nedeni ile yetersiz strüktür gelişimi, yüzey altı horizonlarında düşük
organik madde, yüksek kireç içeriği ve ayrıca zaman zaman oluşan taşkın
tehlikesi, tarımsal üretimi olumsuz yönde etkileyen ortak sorunlardır.  Ayrıca yan dere aluviyalleri üzerinde gelişim
gösteren profillerden P5, P7 ve P9 profillerinde dönemlik taban sularının
izlerine rastlanılmıştır.

Sonuç: Araştırma sonucunda tespit edilen sorunların
giderilmesine yönelik alınacak önlemlerin ve bu sorunlar dikkate alınarak
belirlenecek tarımsal amenajman tekniklerinin, söz konusu alandaki toprakların
sürdürülebilir kullanımları için bir zorunluluk olduğu sonucuna varılmıştır.
THE EFFECT OF PEAT SWAMP WATER ON TOOTH DEMINERALIZATION OF COPPER AND SELENIUM ION
Authors: Ridho Muhammad Rizki , Puspitasari Dewi , Khrisnawan Firdaus I Wayan Arya
Published: August 2020

ABSTRACTBackground: The society of South Kalimantan has high rate of tooth decay. The high rate of tooth decay in South Kalimantan is caused by environmental factors, namely water sources originating from peat swamp. Swamp water has acidic pH can make tooth demineralization or releasing minerals in tooth. One of the minerals that can be demineralized by swamp water is copper ions (Cu2+) and selenium ions (Se4+). The released minerals in tooth makes tooth enamel slowly dissolve and make tooth more susceptible to caries. Objective: to analyze the effect of tooth immersion on peat swamp water on releasing copper and selenium ions. Methods: This research used a laboratory experimental study with eighteen specimens of extracted human maxillary premolar teeth. The specimens were divided into 2 treatment groups ie tap (PDAM) water and peat swamp water immersion, and 1 control group ie artificial saliva immersion. Tooth immersion is conducted for 7 days. The Measurement of copper and selenium ions release using a UV-Vis spectrophotometer. Data were statistically tested using One Way Anova. Result: The mean value of released copper ions in artificial saliva (3.8 ± 0.51 ppm), tap water (3.72 ± 1.02 ppm) and peat swamp water (3.37 ± 0.97 ppm) showed there were no significant differences among all immersion groups. Meanwhile, the mean value of released selenium ions in artificial saliva (7.61 ± 2.34 ppm), tap water (2.4 ± 0.62 ppm) and peat swamp water (0.85 ± 0,38 ppm) showed there were significant differences among all immersion groups on the release of selenium ions, subsequenty test using Post hoc Dunnett's T3 showed p=0.0001 (p<0.05). Conclusion: There is no effect of tooth immersion in peat swamp water on the release of copper ions however there is an effect on the release of selenium ions.Keywords: Demineralization, Peat swamp water, Releasing copper ions (Cu2+), Releasing selenium ions (Se4+), tooth decay.
CORRELATION BETWEEN STRESS AND TEMPOROMANDIBULAR DISORDER IN ORPHANED ADOLESCENT IN BANJARMASIN
Authors: Fellbyan Fellbyan , Arifin Rahmad , Sari Galuh Dwinta
Published: August 2020

ABSTRACTBackground: Temporomandibular disorder is a temporomandibular joint disturbance characterized with the pain in masticatory muscle and TMJ; clicking in TMJ; and deflection, deviation pattern with limitation in opening of the mouth. TMD can be found in adolescents with prevalence and severity increased along with the age. TMD in adolescent was caused by the increased of the masticatory muscle activity. In adolescent, it was caused by the increase of the emotional state especially stress. Stress is a condition that often experienced by every people including orphaned adolescent, who has more problems than the other adolescent. Purpose: The aim of this study was to analyze the correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin. Method: This study is an analytical observational research with cross sectional design. The study was involving 13-18 years old orphaned adolescents in Banjarmasin with purposive sampling. This study is using PSS for stress examination and RDC/TMD for TMD examination. The correlation between stress and TMD were analyzed with Spearman analysis test. Results: This research showed that 61% of the subject had moderate stress level and TMD was found in 68.3% of the subject, which consists of 58.5% had myofascial pain and 9.8% had disc displacement. Spearman analysis test showed that there is statistical correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin (p<0.05). Conclusion: There is a correlation between stress and temporomandibular disorder in orphaned adolescent in Banjarmasin. Keywords: Myofascial Pain, Stress, Temporomandibular disorder (TMD).