bluuebunny/crossref_metadata_2025 huggingface dataset:
Adiabatic Leaky Integrate-and-Fire Neurons with Tunable Refractory Period in 180nm CMOS Technology for Ultra-Low Energy Brain-Inspired Neuromorphic Computing
Authors: Massarotto Marco , Saggini Stefano , Loghi Mirko , Esseni David
Published: May 2024

In recent years, the In-Memory-Computing in charge domain has gained significant interest as a promising solution to further enhance the energy efficiency of neuromorphic hardware. In this work, we explore the synergy between the brain-inspired computation and the adiabatic paradigm by presenting an adiabatic Leaky Integrate-and-Fire neuron in 180 nm CMOS technology, that is able to emulate the most important primitives for a valuable neuromorphic computation, such as the accumulation of the incoming input spikes, an exponential leakage of the membrane potential and a tunable refractory period. Differently from previous contributions in the literature, our design can exploit both the charging and recovery phases of the adiabatic operation to ensure a seamless and continuous computation, all the while exchanging energy with the power supply with an efficiency higher than 90% over a wide range of resonance frequencies, and even surpassing 99% for the lowest frequencies. Our simulations unveil a minimum energy per synaptic operation of 360 fJ at a 500 kHz resonance frequency, which yields a 12x energy saving with respect to a non-adiabatic operation.
Enablers and Barriers to the Implementation of the Food System Transformative Integrated Policy (FS-TIP) in Ghana, Malawi and Rwanda
Authors: Mutoro Antonina N. , Wambui Elizabeth , Ogunsola Ajibola , Amugsi Dickson , Asiki Gershim , Kimani-Murage Elizabeth W.
Published: May 2024

Background/Objective The Food System Transformative Integrated Policy (FS-TIP) is an evidence informed initiative that identifies food system (FS) challenges, policies and stakeholders required for the functioning of FS. It was piloted in three countries and evaluated to identify its perceived relevance, stakeholder readiness to adopt the process, level of stakeholder engagement and enablers and barriers to its implementation.Methods This was a cross-sectional mixed methods study. The perceived relevance and willingness of stakeholders to adopt the FS-TIP initiative was collected using an online semi-structured questionnaire. Key informant interviews were conducted to assess enablers and barriers. A desk review of process outputs was also conducted to assess the level of multi-stakeholder engagement. The study was conducted in Ghana, Malawi and Rwanda. Stakeholders who implemented and validated the initiative.Results Ten stakeholders (Ghana-2; Malawi-5 and Rwanda-3) completed the online survey and twenty-five (Ghana-10; Malawi-6; Rwanda-7 and project management team-2) were interviewed. Stakeholders expressed willingness to adopt FS-TIP, considered it relevant to the African context, designed with policy-makers in mind but difficult to implement. Enablers for FS-TIP included: stakeholder buy-in, the use of local experts and availability of routinely collected data. Lack of centralized databases and limited access to stakeholders and time for implementation were identified as barriers.Conclusion FS-TIP identified FS challenges in Ghana, Malawi and Rwanda. It was considered relevant, acceptable and adoptable by stakeholders and can improve FS policies and diagnostics. The initiative should ideally be government led and integrated in existing initiatives to ensure ownership and sustainability.
New non-radial models for horizontal and acquisition merger to achieve strong efficiency and MPSS without changing in the efficient frontier
Authors: Fakharzadeh A.Reza , Rostamzadeh Hassan
Published: May 2024

In this study, new models for the merger of two or more inefficient units are presented. The discussed mergers in this study are horizontal and acquisition mergers. In presented models, unlike the previously presented models, the mergers are done non-radially; indeed, managers can manage each of the indicators separately in the presented new merger process. In this regard, the efficient frontier of the production possibilities set does not change, and the merger of several units does not affect the efficiency score of other decision-making units. Also, by merging via the new models one can obtain a strong efficient unit with the most productive scale size. The presented models are applied to the horizontal and acquisition merger of Iranian banks.
Computational-Aided Design of Next-Generation Extractants for Trivalent Actinide and Lanthanide Separation
Authors: Xiao Chengliang , Yang Xiaofan , Fang Dong , Chen Linjia , Liu Yaoyang , Wang Shihui , Xu Lei , Zhang Anyun , Su Jing , Xu Chao
Published: May 2024

The chemical similarities between trivalent actinides (An(III)) and lanthanides (Ln(III)) stemming from their analogous ionic radii and physicochemical properties present a significant challenge in differentiating and separating them via solvent extraction, which is a pressing issue in nuclear and radiochemistry. However, the existing approaches suffer from different drawbacks such as inadequate separation factors, limited stripping efficiency, and undesired co-extraction. In this study, a novel unsymmetrical phenanthroline-derived amide-triazine (Et-Tol-CyMe4-ATPhen) extractant was designed with the aid of theoretical calculations and synthesized using an unprecedented de novo construction method. As expected, the Et-Tol-CyMe4-ATPhen extractant exhibited a favorable extraction ability for Am(III) and minimal extraction for Ln(III), thereby achieving an extremely selective An(III)/Ln(III) separation with a separation factor over 280. Furthermore, Am(III) could be effectively stripped from loaded phases using dilute nitric acid. The underlying coordination mechanisms were thoroughly elucidated by using 1H NMR, ESI-MS, UV-Vis absorption spectrum, fluorescence excitation spectrum, and X-ray single-crystal diffraction. This work holds promise for addressing the current challenges in An(III)/Ln(III) separation and represents a pioneering endeavor in developing next-generation extractants from first principles calculation.
Effectiveness and safety of the hyaluronic acid INNORYOS 2.2% in patients with early to advanced knee osteoarthritis. A prospective non-interventional randomized clinical trial.
Authors: Hofweber Lola , von Stengel Simon , Nürnberger Jörg , Kemmler Wolfgang
Published: May 2024

Introduction: We determined the effectiveness and safety of INNORYOS 2.2% hyaluronic acid (HA) containing 15mg of niacinamide on knee pain, stiffness and function in people with knee OA compared with an established agent. Further study objectives were to monitor side effects during the study period.
Methods: The 26-week prospective non-interventional open clinical trial tested on non-inferiority of INNORYOS 2.2% compared to an established HA product (Synvisc 0.8%, 2.0 ml). Briefly, 90 people with knee OA (Kellgren-Lawrence grade I to III), 40–85 years old, were allocated randomly to the two groups. HA injections were carried out at baseline and after 1 and 2 weeks. ANCOVA that adjusted for baseline differences was applied to determine between group differences (i.e. “effects”) after 26 weeks.
Results: None of the 90 participants (65.0 ± 10.5 years, BMI: 30.2 ± 5.5 kg/m2) quit the study or was lost to follow-up. In summary WOMAC pain score (p = .26) and function score (p = .49) did not differ significantly between the groups, but data significant better effect after INNORYOS 2.2% were observed for WOMAC stiffness subscale (p = .009). In detail, changes from baseline to 26-week FU average 43.6% (29.1%) for “pain”, 25.9% (0%) for “stiffness” and 37% (27.6%) for “function” subscale in the INNORYOS (Synvisc) group.
No adverse effects were observed or reported by the participants. As determined by personal interviews and recorded in the questionnaires no changes of co-medication with impact on the study outcomes were observed.
Conclusion: We did not determine significantly lower effects compared with the established product. In contrast, INNORYOS 2.2% tendentially revealed more favourable effect on all WOMAC categories (significant for “stiffness”). Thus, the present study provided further evidence for the effectiveness and safety of INNORYOS 2.2% in patients with early to advanced knee osteoarthritis.
Designing an effective educational toy: incorporating design-thinking and user-centered design in the design classroom
Authors: Houston Natalie , Manrique Ferney
Published: May 2024

“Designing an effective educational toy” is a research project that emerged from a teaching and learning course designed to facilitate creative engagement both inside and outside the classroom at Wenzhou-Kean University in China. This research study examines the incorporation of design thinking and user-centred design concepts in the development of an educational toy by graphic design students. Utilising the ‘Double Diamond Model of Design’, the research methodically progresses through the stages of observation, generation, prototyping, and testing to create a 3D letter-building kit with the goal of improving children's educational experiences. The approach prioritises the integration of ideas through iterative design, taking safety into account, involving users, and focusing on instructional value. The key findings emphasise the effective implementation of design principles in developing a product that not only fulfils safety and educational requirements but also provides novel learning experiences. The essay continues by recommending the wider implementation of these concepts in the creation of educational toys to encourage improved learning outcomes and the development of skills in children.
Harnessing Machine Learning and Ensemble Models for Tourism Potential Zone Prediction for the Assam State of India
Authors: Raha Shrinwantu , Gayen Shasanka Kumar , Deb Sayan
Published: May 2024

Although Assam is enriched with several popular tourist destinations but till date, its’ complete charm remains enigmatic. This research was aimed at prognosticating the Tourism Potential Zone (TPZ) for the state of Assam using five machine learning (i.e., Conditional Inference Tree, Bagged CART, Random Forest, Random Forest with Conditional Inference Tree, and Gradient Boosting models) and one ensemble model. A 5-step methodology was implemented to do this research. First, a Tourism Inventory Database was prepared using the Google earth Imagery, and a rapid field investigation carried out with the help of Global Positioning System and non-participant observation technique. Total 365 tourism points was in the inventory, 70% (224) of which was used for the training set and 30% (124) was used for the validation purpose. The tourism conditioning factors such as Relief, Aspect, Viewshed, Forest Area, Wetland, Coefficient of Variation of rainfall, Reserve Forest, Population Density, Population Growth Rate, Literacy Rate and Road-railway density were used as the independent variables in the modelling process. The TPZ was predicted with the help of above machine learning models and finally, a new TPZ Ensemble Model was proposed by combining each model. The result showed that all machine learning models performed well according to prediction accuracy and finally, the ensemble model outperformed other models by achieving the highest AUC (97.6%), Kappa (0.82) and accuracy (0.93) values. The results obtained from this research using machine learning and ensemble methods can provide proper and significant information for decision makers for the development of tourism in the region.
Implementation of Solar Particle Event Nowcast Approach for Real Time Application
Authors: Burov Vyacheslav , Ochelkov Yuri , Kondratov Andrey , Kholodkov Kirill
Published: May 2024

This short report describes the method of forecasting solar proton events (SPEs) in real time. The implementation monitors electromagnetic flux (particularly, X-ray flux) to pinpoint phases of SPE evolution and possibly predict the oncoming particles tens of minutes beforehand. This approach utilizes statistical methods to provide an algorithm that describes X-ray change vs. time dependency. The implementation is mounted for evaluation in the Russian Segment of China-Russia Consortium - a Global Space Weather Center. As solar maximum is approaching we expect the method to show it's potention in this cycle.
A Comparative Study of Mathematical Models for Two-Dimensional Cutting Stock Problems and Solving Algorithms
Authors: Almani Fatemeh Maleki , Gholamnazhad Mahsa
Published: May 2024

Two-dimensional cutting problem involves cutting a set of small pieces from large sheets in a way that optimizes one or more objectives. The objective of this problem can be minimizing the number of sheets used, waste, cost, and so forth. These problems have various applications in different industries such as glass, paper, wood, plastic, steel, etc. This paper studies one of the recent exact polynomial models proposed for these problems. Although the presented model, named Original(a), is quite promising for finding a solution, since these problems belong to the mixed integer non-linear programming model (MINLP) group, solving them will be difficult. Therefore, a linearization technique by multiplying continuous variables for this model would be used. The goal is to find an optimum solution. The studied models are implemented in the Matlab environment and the results of numerical experiments are presented.
Influence of Interparental Conflict on Teen Dating Violence: A Review
Authors: Kumari Shanta , Gupta Smita
Published: May 2024

Research indicates a significant impact of parenting on adolescents’ (teens’) psychological health. Furthermore, the effect of interparental conflict on adolescents’ internalizing and externalizing behavior has been well researched. However, the effect of interparental conflict (in intact families) on teen dating violence is underresearched. Using a literature review, the present study is an attempt to examine the emerging trends in dating relationships among adolescents. With the help of existing studies, the present paper aims to analyze the association between interparental conflict and dating relationships among teens. This systematic study revealed significant findings. It was found that those teens who perceived interparental conflicts at home, showed maladjustment behavior in their dating relationships. Even the study proposes the relevance of certain interventions that can help teenagers improvise their romantic/partner relationships as well as their parents.
Klatsche oder Kantersieg?
Authors: Meier-Vieracker Simon
Published: May 2024

Der Beitrag untersucht Perspektivierungen als zentrales Mittel der parteiischen Fußballberichterstattung auf den Websites einzelner Fußballvereine der deutschen Bundesliga aus frame-semantischer Sicht. Anhand eines Korpus von 582 Fußballspielberichten mit je zwei Texten zum gleichen Spiel aus zwei unterschiedlichen Perspektiven wird gezeigt, wie und mit welchen sprachlichen Mitteln der Spielverlauf und einzelne Szenen auf den Websites der Sieger- und der Verlierermannschaft unterschiedlich geframet werden. Sowohl mit quantitativen Methoden wie der Keywordanalyse und der automatisierten frame-semantischen Annotation als auch mit qualitativen Methoden wird gezeigt, dass unterschiedliche Framings derselben Ereignisse und Szenen unterschiedliche Bewertungen ermöglichen. Da Fußballspielberichte das Fußballwissen der Autor*innen zum Ausdruck bringen müssen, besteht dieses Wissen nicht zuletzt in der Fähigkeit, Bewertungen zielgruppenadäquat und auf kohärente Weise zu vermitteln.
Argyreia nervosa Mitigates Insulin Resistance in Liver via IR/IRS-1 Mediated Signaling in Streptozotocin-Induced Type-2 Diabetic Rats
Authors: Suresh Lakshana , Priya Veeraraghavan Vishnu , Jayaraman Selvaraj , Gayathri R. , S Kavitha.
Published: May 2024

Argyreia nervosa, commonly known as Hawaiian baby woodrose or wooly morning glory, is a plant native to India and is also found in various parts of the world. It is known for its seeds, which have been used traditionally in Ayurvedic and traditional medicine systems for various diseases. The study was aimed at assessing the effect of Argyreia nervosa on insulin signaling molecules of the liver in streptozotocin (STZ)-induced experimental type-2 diabetic rats. Healthy adult male Wistar albino rats -150-180 days old weighing 180-200g was used for the study and divided as Group I - Normal rats; Group II – type-2 diabetic rats; Group III -Diabetic rats + A. nervosa 500 mg/kg b.wt; Group IV-Normal rats + A. nervosa 500 mg/kg b.wt. Fasting blood glucose, and fasting serum insulin were measured by calorimetric methods. Further mRNA expression analysis of insulin receptor (IR) was measured in control and treated animals by quantitative Ream Time PCR analysis. A. nervosa root extract significantly reduced fasting blood glucose and serum insulin concentrations in STZ-induced rats compared with control. In addition, mRNA expression of IR showed a one-fold increase in the expression which shows that A. nervosa is involved in the regulation of insulin signaling in the liver and thereby reduces insulin resistance and type-2 diabetes. Our study concludes that A. nervosa root extract has a significant role on insulin signaling molecules thereby it reduces hyperglycemia and hyperinsulinemia via insulin receptor-mediated pathways. Hence, A. nervosa may be considered as one of the therapeutic natural antidiabetic drugs.
Effect of Laser Therapy in the Treatment of Chronic Rhino Sinusitis: A Review
Authors: M. Allam Nesma , Mosad Eladl Hadaya , H Allam Ahmed , Loay Bohairi Abdullah , Eldesouqi Mamdouh , Mahmoud Abdelmonem Elsherbini Dalia , El-Sherbiny Mohamed , Priya Veeraraghavan Vishnu , Jayaraman Selvaraj , Mohammad AlOmar Safana
Published: May 2024

Chronic Rhino Sinusitis (CRS) is one of the most prevalent chronic illnesses affecting people of all ages. The various etiological causes and challenging diagnostic techniques have a role in misdiagnosis and severity of sinusitis. There is no typical sinusitis therapy. There are many new and developing treatments, both natural and developed, and staying up to date on these therapies and their effectiveness is still difficult. As new CRS treatment alternatives, low-level laser therapy and near-infrared laser therapy have generated some interest. According to certain research, these photo-therapies use various light wavelengths and intensities to decrease the production of biofilms and enhance the in vitro activity of antibiotics against sinus infections. On contrast to this, some studies concluded that phototherapy for CRS is still in its relative infancy and that better studies are required to accurately evaluate its therapeutic impact. The goal of this review was to gather data regarding how Laser therapy affected chronic sinusitis.
Fabrication, Characterization of Curcumin Loaded Alginate Chitosan for Potential Wound Healing Applications
Authors: Sivakumar Aravind , Priya Veeraraghavan Vishnu , Gayathri R. , S Kavitha
Published: May 2024

The most employed scaffolds in tissue engineering are alginate and chitosan due to their properties like biodegradability, compatibility, and structural similarity to that of the ECM. Curcumin, together with scaffolds such as alginate and chitosan, can improve wound healing properties by tissue repair and regeneration. This study aims to load curcumin into alginate chitosan scaffolds and to analyze their potential wound healing properties by characterization and checking their biocompatibility. Curcumin was loaded into the alginate-chitosan scaffold. It was then characterized using Fourier Transform-InfraRed (FT-IR) spectroscopy and Scanning Electron Microscopy (SEM). Annexin V PI apoptotic assay and Hemolytic assay were done to screen its biocompatibility. FT-IR has strong absorption bands at 3237, 2359, 1597, 1406, 1025, and 947 cm−1. SEM analysis of the curcumin-loaded alginate-chitosan scaffold showed the dispersed curcumin on the surface of the porous scaffold. Our results suggest that the curcumin-loaded alginate-chitosan scaffold possesses greater biocompatibility towards peripheral blood mononuclear cells (PBMC) which was confirmed by Annexin V - PI assay and hemolytic assay. Curcumin loaded onto an alginate-chitosan scaffold is reported to be biocompatible using flow cytometry and hemolytic assay. However a more detailed study must be done before using it for potential wound healing applications.
Effect of Diosmin on mTOR/Akt Signaling Molecules in NDEA-induced Hepatocellular Carcinoma in Experimental Rats
Authors: Shankar Nithish , Priya Veeraraghavan Vishnu , Jayaraman Selvaraj , S Kavitha , Gayathri R.
Published: May 2024

Background: Diosmin is a natural compound with a wide range of biological activity, e.g., it improves lymphatic drainage, supports microcirculation, and increases venous tone, and venous elasticity, hence, it is applied in the pharmacotherapy of chronic venous disorders (CVD). This work aims to analyze the effect of diosmin on mTOR and Akt-signaling molecules in NDEA-induced hepatocellular carcinoma (HCC) in experimental rats. Materials and Methods: Healthy adult rats were split into four groups randomly. Each group consisted of 6 animals. Group I: Control, Group II: NDEA-induced hepatocellular carcinogenic rats, Group III: Cancer-bearing animals treated with diosmin (200 mg) orally for 28 days. Group IV: Control animals treated with diosmin (200 mg) alone for 28 days. Liver function markers (ALP and AST) were measured by biochemical analysis while mTOR and Akt mRNA expression were analyzed by q-PCR analysis. Results: ALP and AST concentration in the serum and mRNA expression of the transcription factor, mTOR were found to be upregulated in HCC bearing rats but Akt mRNA expression was reduced. However, a 200 mg dose of diosmin controls the altered levels of liver function markers and signalling molecules. Conclusion: Results of this study suggest that diosmin may be one of the pharmacological and therapeutic natural compounds against hepatocellular carcinoma.
Molecular Docking Analysis of Epigallocatechin 3- Gallate [EGCG] on Fatty Acids and Carnitine Transporters Family
Authors: L Aarthi , Renu Kaviyarasi , Vishnu Priya Veeraraghavan , R Gayathri , S Kavitha
Published: May 2024

EGCG is the main catechin present in green tea. Fatty acids can be categorized as saturated or unsaturated depending on the hydrocarbon chain and terminal carboxyl group they contain, typically with an even number of carbons. EGCG has attracted considerable interest because of its several health benefits, such as its anti-inflammatory, antioxidant, and anticancer characteristics. Yet, the precise molecular targets and mechanisms of action are not fully understood. Exploring the potential interaction of EGCG with fatty acids and carnitine transporters, which play a vital role in lipid metabolism and energy production, could provide insights into its physiological effects. Analysis of molecular docking between EGCG and fatty acid and carnitine transporters, and their interactions. A contact and binding occur between the fatty acid transporters (FABP) and VLCAD and CPTII. EGCG was subjected to molecular docking simulations with active sites of transporter families such as FABP, CPT2, and VLCAD. The docking analysis showed that EGCG has favourable binding interactions with the target transporters, involving important hydrogen bonding and hydrophobic interactions. EGCG showed a strong ability to bind to the active sites of FABP and CPT2, indicating its potential to influence their functions.
Evaluation of Antioxidant and Xanthine Oxidase Inhibitory Potential of Methanolic Extract of Myristica fragrans (Mace)
Authors: M Bingha. , R Gayathri. , Vishnu Priya V. , Selvaraj J. , S Kavitha.
Published: May 2024

Myristica fragrans is commonly named as nutmeg or mace. It is native to Moluccas of Indonesia. It is used in folk medicine. Phytochemicals present in the plant are responsible for the medicinal properties of the plant. Antioxidants neutralise the free radicals that are produced in our body due to various biochemical reactions .Gout is a clinical condition caused due to accumulation of Uric acid crystals in one or more joints leading to inflammation. Xanthine oxidase inhibitory potential of the extract helps in preventing excess production of uric acid. The extract was found to be rich in phytochemicals such as saponin, alkaloid, terpenoids and flavonoids. The IC50 for the antioxidant potential of the extract was 280µg/ml and the IC 50 for the xanthine oxidase inhibitory potential of the extract was 320 µg/ml.
Evaluation of Antidiabetic Potential of Methanolic Extract of Myristica fragrans (Mace) and Cinnamomum Verum- A Comparative in Vitro Study
Authors: Blessy Sheron , R Gayathri , Vishnu Priya V , Selvaraj J , S Kavitha
Published: May 2024

Myristica fragrans (mace) and Cinnamomum verum are traditional medicinal plants which are used as spices in flavouring of food. They exhibit various medicinal properties. Diabetes is a condition that impairs the body’s ability to process blood sugar levels. Anti-diabetic drugs are used to stabilize and control blood glucose levels. From the study, it was evident that the methanolic extract of Myristica fragrans (mace) exhibited significantly increased antioxidant and anti-diabetic potential when compared to that of Cinnamomum verum.
Impact of Glyphosate on the Development of Type-2 Diabetes in Adipose Tissue: Role of Insulin-Like Growth Factor 1 and Tumor Necrosis Factor Alpha Expression
Authors: Rajiv Ranjan Medha , Priya Veeraraghavan Vishnu , Jayaraman Selvaraj , Gayathri R. , S Kavitha.
Published: May 2024

Glyphosate, a commonly used herbicide in agricultural and residential settings, has sparked concerns regarding its potential health impacts. Despite numerous studies exploring potential associations between glyphosate exposure and diabetes, the precise mechanisms remain unclear. Tumor Necrosis Factor-alpha (TNF-α) and Insulin-Like Growth Factor 1 (IGF-1) are implicated in insulin resistance and pancreatic beta cell dysfunction, playing crucial roles in diabetes pathogenesis, especially Type 2 diabetes. This study aimed to assess the effect of glyphosate on TNF-α and IGF-1 expression in male Wistar rats. The results revealed a dose-dependent increase (p<0.05) in TNF-α and IGF-1 expression in adipose tissue following glyphosate exposure compared to the control group. These findings suggest that glyphosate exposure may contribute to the development of diabetes by altering the expression of IGF-1 and TNF-α.
Preliminary Phytochemical Analysis and Anti-Cholesterol Potential of Ethanolic Seed Extract of Illicium Verum
Authors: B Vaishali , R Gayathri , Vishnu Priya V , Selvaraj J , S Kavitha
Published: May 2024

Illicium Verum commonly called star anise, which is indigenous to northeast Vietnam and Southwest China. Illicium verum is one of the vital ingredients of Chinese medicinal herbs. Principal component (Trans-anethol) exhibits antimicrobial activity such as antiviral, anti-bacterial, antifungal and antiparasitic activities. Cholesterol, a waxy or fat like substance which is found in each and every cell of our body. Cholesterol helps our metabolism work efficiently, but if our body has too much cholesterol in blood, it causes several harmful effects. Anti-cholesterol drugs are useful in reducing the blood cholesterol level. Ethanolic extract of Illicium verum was found to be rich in phytochemicals such as Alkaloids, terpenoids and steroids. The ethanolic extract of illicium verum exhibited a significant antioxidant potential (Ic50 = 300 µg/ml) and anti-cholesterol potential (Ic50 = 400 µg/ml) as compared to standard drugs.
Enhanced biodegradation of phenol under Cr(VI) stress by microbial collaboration and potential application of machine learning for phenol biodegradation
Authors: Bing Wenrong , Li Xinyu , Liang Mingzhao , Zhou Xu , Zhang Jianfeng , Liang Jing
Published: May 2024

Cr(VI) and phenol commonly coexist in wastewater, posing a great threat to the environment and human health. However, it is still a challenge for microorganisms to degrade phenol under high Cr(VI) stress. In this study, the phenol-degrading strain Bacillus cereus ZWB3 was co-cultured with the Cr(VI)-reducing strain Bacillus licheniformis MZ-1 to enhance phenol biodegradation under Cr(Ⅵ) stress. Compared with phenol-degrading strain ZWB3, which has weak tolerance to Cr(Ⅵ), and Cr(Ⅵ)-reducing strain MZ-1, which has no phenol-degrading ability, the co-culture of two strains could significantly increase the degraded rate and capacity of phenol. In addition, the co-cultured strains exhibited phenol degradation ability over a wide pH range (7–10). The reduced content of intracellular proteins and polysaccharides produced by the co-cultured strains contributed to the enhancement of phenol degradation and Cr(Ⅵ) tolerance. The determination coefficients R2, RMSE, and MAPE showed that the BP-ANN model could predict the degradation of phenol under various conditions, which saved time and economic cost. The metabolic pathway of microbial degradation of phenol was deduced by metabolic analysis. This study provides a valuable strategy for wastewater treatment containing Cr(Ⅵ) and phenol.
Transnacionalização da justiça em Nancy Fraser
Authors: Pereira Prestupa Pamela , José Gourart Maria
Published: May 2024

Based on the analysis of the theoretical-social assumptions that link Habermas' initial conception of the public sphere to the Westphalian framework of public space, Nancy Fraser proposes the need for restructuring the public sphere based on a transnational framework, given the existence of discursive arenas that go beyond the limits of the Nation State, with a strong influence on social reality. In this context, Fraser emphasizes that the concept of public sphere was developed not only to understand communication flows, but also to contribute to a normative political theory of democracy. In this theory, a public sphere is conceived as a space for the communicative generation of public opinion. Aiming to guarantee that the process is inclusive and fair, publicity should discredit views that cannot withstand critical scrutiny, for the purpose of ensuring the legitimacy of those who participate in the process. Therefore, it matters who participates and under what conditions. In these terms, two ideas are central to the analysis of the public sphere: normative legitimacy and the political effectiveness of public opinion. The absence of these elements renders the concept empty of critique and political action, according to Fraser. Therefore, the author seeks to rethink the Habermasian public sphere theory, which is implicitly guided by a Westphalian political imaginary, a vision that no longer corresponds to contemporary globalized reality.
Aspectos da plataformização educacional na educação básica brasileira
Authors: Lopes Wilke Valéria Cristina , Santos Feijó Marcelo
Published: May 2024

We live in the unfolding of what Manuel Castells (2005) named Network Society, whose core are Information Technologies (TIs). He indicated the key features of the new scenario that he diagnosed, namely, technologies that act on information itself and that also introduced the logic of networks; that promote technological convergence and therefore, a highly integrated system of technical apparatuses; and that sharply penetrate the different social processes and spheres. Since then, we have witnessed great and rapid technological leaps as well as the consolidation of transformations in the organizational and institutional economic-political dynamics and in the construction of human and non-human lives on the planet. These changes have reached not only informal modes of learning, but also formal education. The aim of this article is to discuss current aspects of the use of digital platforms in education present in Brazilian basic education, with reference to the teaching of Philosophy in High School. To this end, we will reflect on the platformization of education, business model present in the current phase of capitalism and that uses the platforms supported by AI, and also the constant extraction of data from those who transit through the Information Highway of cyberspace; about what we name as School of Fatigue, in dialogue with the concept of Burnout Society developed by Byung Chul Han; and on some implications arising that are already present in the administration of teaching work, in teaching practice and teaching-learning relations.
Synthesis and Antitumor Activities of Novel 5-amino-3-(halophenyl)-1- phenyl-1H-pyrazole-4-carbonitriles
Authors: Abd El-Wahab Ashraf H. F.
Published: May 2024

:

In this work, a series of novel 3-(halophenyl)-1-phenyl-1H-pyrazole moieties have
been synthesized. Their structures were characterized by IR, NMR, and MS spectroscopy, and
the corresponding antitumor properties were also studied.

Objectives:

This study aimed to synthesize a series of new 3-(halophenyl)-1-phenyl-1Hpyrazole
moieties and survey the antitumor properties of these compounds.

Materials and Methods:

3-(halophenyl)-1-phenyl-1H-pyrazoles (4a-j) were prepared by reaction
of phenyl hydrazine (3) with different halogen aromatic aldehydes 1a-j and malononitrile
(2) in C2H5OH and piperidine. The reaction took place under microwave irradiation settings for
two minutes at140°C.

Results:

Three human cancer cell lines were used as in vitro test subjects for compounds 4a - j.
Three cell lines from mammals HeLa (a cell line for human cervical cancer), MCF-7 (a cell
line for human breast cancer), and PC-3 (a cell line for human prostate cancer), all with 5-
fluorouracil as the standard reference drug were used.

Conclusion:

A series of novel 3-(halophenyl)-1-phenyl-1H-pyrazoles were synthesized in this
work. All substances had their anticancer properties assessed.
Analysis of Seven Terpenoids by HS-SPME Coupled with GC-MS for the
Identification and Classification of Different Teas
Authors: Xie Yangzhou , Yang Yi , Tian Yu , Liu Zhimin , Xu Zhigang , Jiang Wei , Liu Zhihua , Si Xiaoxi
Published: May 2024

Background:

Terpenoids are essential aroma substances in teas, and their concentration
brings various characteristics to different teas. Therefore, developing a simple and stable method is
necessary for distinguishing tea categories.

Objective:

In previous studies, more attention was paid to non-chiral isomers of terpenes due to the
challenges of separating chiral isomers. So, this paper aims to present a method for effectively separating
seven terpenoid substances, including chiral isomers and non-chiral isomers, to facilitate the
classification and identification of teas.

Methods:

A method utilizing headspace solid-phase microextraction coupled with gas chromatography-
mass spectrometry was used to isolate and analyze 7 terpenoid compounds. After optimized
conditions, the BGB-176 chiral column and the PDMS/DVB fiber were selected for subsequent
analysis.

Results:

This method has a good linear range of 0.1-200 mg/L, and its linear correlation coefficients
are between 0.9974 and 0.9994, and the limit of detection and the limit of quantification is 0.02–0.03
and 0.06–0.09 mg/L, respectively. Only five terpenoid substances were detected in a total of 15 tea
samples. Furthermore, In the detection of carvon and α-ionone optical isomers, the S isomer was
mainly detected.

Conclusions:

An effective approach was developed to separate and analyze 7 terpenoid compounds
in natural and synthetic teas. Meanwhile, 15 tea samples can be identified and classified using principal
component analysis.
Deployment of a Phenotypic Characterization System for Effective Identification of the Onset of Asthma Disease
Authors: R Pooja M. , Ravi Vinayakumar , Al Mazroa Alanoud , Ravi Pradeep
Published: May 2024

Background

Essentially, machine learning techniques help with clinical decision-making by forecasting prediction results based on recent and historical data, which are frequently found in carefully chosen clinical data repositories. In order to uncover hidden patterns in the data, machine learning applies sophisticated analytical techniques that conduct an exploratory analysis while constructing prediction models to support clinical judgment.

Objective

To effectively identify asthmatics in two distinct cohorts representing India's rural and urban populations by adopting a phenotypic characterization approach.

Methods

Cross-sectional and categorical in design, the data represent the two populations, with clinical history information emphasizing clinical symptoms and patterns defining the condition. The method adopts a hybrid approach since it uniquely blends the unsupervised and supervised learning techniques to explore the advantages of both. The clustering data emphasizing the phenotypic characteristics of asthma is input to the classifier, and the performance of the classifier was continuously monitored for significant improvement in the results.

Results

Asthma disease outcome predictions made by the hybrid decision support system were quite accurate, with classification accuracy reaching up to 85.1% and 95.3% for the two datasets, respectively.

Conclusion

Since asthma is a heterogeneous disease with multiple subtypes, employing clustering information in the form of cluster evaluation scores as an input parameter to the classifiers can effectively predict disease outcomes.
Evaluating the Health Effects of COVID-19 Vaccination on the Population of East Punjab (India): A Comprehensive Survey
Authors: Aggrawal Chirag , Mohan Chander , Ayush  , Gupta Ashna , Kumar Deepak , Kumar Ashish , Kamboj Sweta , Kamboj Shikha , Guarve Kumar , Kamboj Rohit
Published: May 2024

Background:

The impressive and innovative efforts of scientists worldwide have played a
pivotal role in shaping the development and production of COVID-19 vaccines, widely acknowledged
as vital resources for pandemic control.

Objective:

The primary aim of this investigation was to identify the prevailing effects linked to these
vaccines, particularly considering their implications for human well-being.

Methods:

An online survey was conducted in various cities in India, and a trial version of Qualtrics
CoreXM software was implemented to prototype 22 questionnaires.

Result:

After vaccination, respondents reported health changes: skin (26.9%), eye (22.3%), stomach
issues (22.8%), respiratory (12.5%), and mental health (2.9%). Among 1,047 participants, 8.9% had
intercourse, 11.3% men, 7.3% women. 17.9% were unsure; 19.7% were men, 13.7% were women,
and 37.5% were "others". A majority (73.3%) reported no sexual experiences: 68.9% men, 78.8%
women, and 62.5% "others".

Conclusion:

This study offers an extensive perspective on the vaccination situation in the northern
region of India. It delves into the intricate demographic factors influencing vaccine acceptance and
understanding potential side effects. These discoveries contribute substantially to the ongoing conversation
regarding the COVID-19 vaccination and its various impacts on public health and societal
welfare.
PENGARUH FORMULASI JAHE, SECANG DAN KAYU MANIS TERHADAP KARAKTERISTIK FISIK, KIMIA DAN ORGANOLEPTIK MINUMAN TRADISIONAL INSTAN CHING JAE
Authors: Akbar H. ANR Riyadlul , Sofia Murtini Erni , Setyo Yuwono Sudarminto
Published: May 2024

Pembuatan minuman ching jae dilakukan dengan pencampuran ekstrak cair dari jahe, secang dan kayu manis. Proses selanjutnya adalah ditambahkan gula pada campuran ekstrak cair tersebut dan dilakukan proses kristalisasi. Senyawa aktif pada bahan tersebut bersifat labil terhadap panas sehingga diperlukan kondisi ekstraksi yang dapat mempertahankan senyawa aktifnya. Penelitian ini bertujuan mendapatkan formulasi minuman ching jae dengan sifat fisik, kimia dan organoleptik terbaik. Penelitian ini menggunakan rancangan acak kelompok (RAK) dengan dua faktor, yaitu konsentrasi sari yang jahe (35%, 37,5% dan 40%) dan konsentrasi ekstrak secang (10%, 12,5% dan 15%). Proses pembuatan ching jae dilakukan dengan ekstraksi sari jahe dengan penggilingan dan ekstraksi secang dan kayu manis melalui proses perebusan pada suhu 100°C selama 45 menit. Ekstrak jahe, secang dan kayu manis yang telah didapat kemudian digunakan untuk proses formulasi. Larutan hasil formulasi kemudian dimasukkan ke dalam alat pemasakan dengan penambahan gula 500 g selanjutnya dilakukan proses kristalisasi. Bubuk tersebut kemudian diayak dengan ayakan 30 mesh. Analisis yang dilakukan meliputi warna, pH, total fenol, antioksidan dan total padatan terlarut (TPT). Analisis sensori meliputi warna, aroma dan rasa. Formulasi terbaik ditentukan dengan Multiple Atribute Test (Zelleny). Penelitian ini menghasilkan formulasi terbaik pada konsentrasi jahe 40% dan secang 5%. Minuman ching jae perlakuan terbaik memiliki nilai L 39,55; a 35,48; b 35,12; total fenol 342,30 mg GAE/g; aktivitas antioksidan (IC50) 167,13 ppm; TPT 14,50 OBrix; pH 7,13. Kesukaan terhadap warna 4,65/5; aroma 3,90/5 dan rasa sebesar 4,20/5.
Factores de la innovación para el desarrollo de políticas de sustentabilidad en los sectores productivos
Authors: Raynaud Prado Nathalie Claire , Maldonado Niño Lissette Gabriela , Landazury Villalba Luis Fernando , Rodriguez Gaviria Ronald
Published: May 2024

Introducción: La innovación es un elemento que ofrece a los empresarios ventajas competitivas en productos y procesos. Objetivo: Examinar los factores de la innovación para desarrollar políticas de sostenibilidad en los sectores productivos. Metodología: Cualitativa con un enfoque deductivo, que se aplicó en una investigación documental utilizando la innovación y la sostenibilidad como fuentes primarias de información. Resultados: Los resultados revelan hallazgos significativos sobre el desarrollo tecnológico e innovación, identificando factores clave para la competitividad y el crecimiento tanto a nivel regional como nacional, destacando, además, una estrecha relación entre la innovación y los sectores productivos. Conclusiones: El análisis sugiere que las políticas de sostenibilidad están estrechamente vinculadas con niveles más altos de productividad en las organizaciones, por lo que este estudio resalta la importancia de fomentar la innovación como un medio para promover la sostenibilidad y mejorar la competitividad en los diferentes ámbitos empresariales.
Fire Performance of Endospermum malaccense Cross Laminated Timber (CLT) Treated with Fire Retardant
Authors: Jabar Khairul Azmi , Husain Hamdan , Smith Wanda , Lee Lee Seng Huat
Published: May 2024

This study assessed the fire performance of cross-laminated timber (CLT) made from sesenduk (Endospermum malaccense) painted with a fire retardant. Teknoksafe 2407 (Tk-Exterior) and Teknoksafe 2457 (Tk Interior) fire retardants were prepared and applied to the sesenduk CLT. Fire properties such as surface spread of flame test, charring rate test, fire resistance test, and chemical property changes before and after fire testing were evaluated and compared to Control CLT. The results showed that using fire retardant effectively prevented the fire from spreading.
Resistance of Green Treated Dendrocalamus asper (Buluh Betong) against Aspergillus brasiliensis Attack
Authors: Abdul Karim Siti Rafedah , Abdul Kadir Yanti
Published: May 2024

Dendrocalamus asper, D.asper (Buluh Betong) were pressure treated with a plant-based extract from (Cinnamomum camphor (l.) presl)  and Cymbopogon citratus Stapf.). The durability of treated D. asper toward mould (Aspergillus brasiliensis) attack was evaluated. Camphor leaf extract has strong antifungal compounds, including D-camphor,  eucalyptol, α-terpineol, linalool,  and 4-terpineol that suppress mould activity. Fixing the camphor extract with 10%, MUF increased mould resistance as compared to treatment with camphor extract alone. Treatments were selected based on the initial screening test that showed the inhibitory effect of mould. Results showed the potential of plant extracts as green bamboo treatment.
Local Plant Motif of Kain Suket Ajang
Authors: Mohamad Morni Asrul Asshadi , Samin Mohd Azhar , Legino Rafeah
Published: May 2024

This study delves into the identity of Suket Ajang, a traditional craft in Sarawak, particularly among Rajang's Melanau population. Employing semiotics, the research deciphers the complex meanings and cultural nuances embedded in Suket Ajang's native plant motifs. Through an in-depth examination of literary and visual materials, the study unveils the symbolic language within Suket Ajang, showcasing how individual motifs are chosen, investigated, and classified based on their semiotic qualities. This method sheds light on the aesthetic and semiotic elements, revealing the intricate blend of local plant features. Notable motifs like buwak tulau and tapok pedadah further contribute to Suket Ajang's rich cultural identity.
Potential of Coconut Husk Material as a Sustainable Block Batik Development Tool
Authors: Ma’aris Nurul Najwa , Samin Mohd Azhar , Zakaria Mohd Nazarudin
Published: May 2024

Coconut (Cocos nucifera) is Malaysia's fourth-largest industry, and its outer husk is a sustainable, accessible, and cheap fibrous waste. The rise of copper as the primary material has affected the making of blocks ‘sarang’ tools and, in turn, impacted the selling price. If these issues continue, it could push the Malaysian block batik to the brink of extinction. Thus, sustainability towards the blocks ‘sarang' is required. This paper discovers and explores potential solutions through sustainable materials as new materials to minimise the cost. The result will give alternative materials besides copper to facilitate the growth of the Malaysian batik industry.
Punk Fashion as a Wearable Art Mask
Authors: Che Mat Anis , Zuhir Nikfarhana , Md Arif Mohd Fuad
Published: May 2024

This research analyses how punk fashion influenced wearable art masks, detailing their artistic characteristics. Investigating the use of punk style in creating masks, it explores its diverse role in spirituality, performance, and self-expression. Artists utilised masks as a means of self-representation outside of the punk subculture, using diverse materials and techniques. This study describes the integration of punk identity into wearable art, showcasing experiments with waste materials and ready-purchased materials. This discovery highlights the innovative use of materials and techniques in making mask sculptures, contributing to understanding the fusion of punk fashion with wearable art.
Activities of Daily Living (ADL) Innovation towards Sustainable Quality of Life for the Elderly
Authors: Toyong Natrina , Yahaya Nizar
Published: May 2024

Concerns about ageing relate not only to the size of the elderly population but also to their health, well-being, care, and living arrangements. This paper explores articles and journals to discover concepts, definitions, and issues related to activities of daily living for an ageing population in Malaysia. The content analysis will inform future in-depth interviews and demonstrative evidence to examine the Activities of Daily Living (ADL) towards the concept of Aging in Place as an independent lifestyle. The result will provide a practical solution for ADL aids that can be used by the elderly towards a better quality of life.
Distribution of Endangered Dipterocarps in the Freshwater Swamp Forest of Parit Forest Reserve, Perak
Authors: Suratman Mohd Nazip , Che Abdulah Siti Maisarah , Gisip Judith
Published: May 2024

Many endangered tree species suffered reductions in their population sizes due to forest fragmentation. A field survey was conducted to study the demographic structure of five threatened Dipterocarps species and to map their spatial distribution in freshwater swamp forests at Parit Forest Reserve, Perak, Malaysia. Of five species recorded, Shorea hemsleyana exhibited the highest number of individuals (i.e., 198), followed by Dipterocarpus semivestitus (35), S. macrantha (24), Hopea apiculata (14) and Vatica flavida (6). While the spatial distribution of D. semivestitus, S. macrantha, H. apiculata and V. flavida are appreared to be spatially dispersed, S. hemsleyana’s appears to be more localized.