bluuebunny/crossref_metadata_2025 huggingface dataset:
Hydrolysis of Dinuclear Ruthenium Complexes [{CpRu(PPh3)2}2(μ,η1:1‐L)][CF3SO3]2 (L=P4, P4S3): Simple Access to Metal Complexes of P2H4 and PH2SH
Authors: Barbaro Pierluigi , Di Vaira Massimo , Peruzzini Maurizio , Seniori Costantini Stefano , Stoppioni Piero
Published: May 2007

The reaction of [CpRu(PPh3)2Cl] (1) with half an equivalent of P4 or P4S3 in the presence of AgCF3SO3 as chloride scavenger affords the stable dimetal complexes [{CpRu(PPh3)2}2(μ,η1:1‐P4)][CF3SO3]2⋅ 3 CH2Cl2 (2) and [{CpRu(PPh3)2}2(μ,η1:1‐Papical‐Pbasal‐P4S3)][CF3SO3]2⋅ 0.5 C7H8 (3), in which the tetrahedral P4 and mixed‐cage P4S3 molecules are respectively bound to two CpRu(PPh3)2 fragments through two phosphorus atoms. The coordinated cage molecules, at variance with the free ligands, readily react with an excess of water in THF under mild conditions. Among the hydrolysis products, the new, remarkably stable complexes [{CpRu(PPh3)2}2(μ,η1:1‐P2H4)][CF3SO3]2 (4) and [CpRu(PPh3)2(η1‐PH2SH)]CF3SO3 (8) were isolated. In the former, diphosphane, P2H4, is coordinated to two CpRu(PPh3)2 fragments, and in the latter thiophosphinous acid, H2PSH, is coordinated to the metal centre through the phosphorus atom. All compounds were characterised by elemental analyses and IR and NMR spectroscopy. The crystal structures of 2, 3, 4 and 8 were determined by X‐ray diffraction.
Novel Transition‐Metal‐Free Heterogeneous Epoxidation Catalysts Discovered by Means of High‐Throughput Experimentation
Authors: Pescarmona Paolo P. , Janssen Kris P. F. , Jacobs Pierre A.
Published: May 2007

Various transition‐metal‐free oxides have been studied as catalysts for the epoxidation of cyclooctene with hydrogen peroxide by means of high‐throughput experimentation. Different boron, aluminium, and gallium oxides were prepared according to various synthesis methods. A number of pure aluminium and gallium oxides showed very good catalytic performances, while the results obtained with boron oxides or mixed oxides were less positive. The best results were obtained with a gallium oxide catalyst, which gave an epoxide yield of 71 % and a selectivity of 99 % after reaction for 4 h at 80 °C. Gallium oxides had not been reported previously as active epoxidation catalysts. The use of high‐throughput experimentation proved useful both for discovering new active catalysts and for identifying a number of relationships between the synthesis conditions and the catalytic properties of the transition‐metal‐free oxides.
Copper Halide‐Bridged Ruthenium Telluride Carbonyl Complexes: Discovery of the Semiconducting Cluster Chain Polymer {[PPh4]2[Te2Ru4(CO)10Cu4Br2Cl2]⋅THF}∞
Authors: Shieh Minghuey , Hsu Miao‐Hsing , Sheu Wen‐Shyan , Jang Li‐Fing , Lin Shu‐Fen , Chu Yen‐Yi , Miu Chia‐Yeh , Lai Yun‐Wen , Liu Hsiang‐Lin , Her Jim Long
Published: May 2007

A new series of Te–Ru–Cu carbonyl complexes was prepared by the reaction of K2TeO3 with [Ru3(CO)12] in MeOH followed by treatment with PPh4X (X=Br, Cl) and [Cu(MeCN)4]BF4 or CuX (X=Br, Cl) in MeCN. When the reaction mixture of K2TeO3 and [Ru3(CO)12] was first treated with PPh4X followed by the addition of [Cu(MeCN)4]BF4, doubly CuX‐bridged Te2Ru4‐based octahedral clusters [PPh4]2[Te2Ru4(CO)10Cu2X2] (X=Br, [PPh4]2[1]; X=Cl, [PPh4]2[2]) were obtained. When the reaction mixture of K2TeO3 and [Ru3(CO)12] was treated with PPh4X (X=Br, Cl) followed by the addition of CuX (X=Br, Cl), three different types of CuX‐bridged Te–Ru carbonyl clusters were obtained. While the addition of PPh4Br or PPh4Cl followed by CuBr produced the doubly CuBr‐bridged cluster 1, the addition of PPh4Cl followed by CuCl led to the formation of the Cu4Cl2‐bridged bis‐TeRu5‐based octahedral cluster compound [PPh4]2[{TeRu5(CO)14}2Cu4Cl2] ([PPh4]2[3]). On the other hand, when the reaction mixture of K2TeO3 and [Ru3(CO)12] was treated with PPh4Br followed by the addition of CuCl, the Cu(Br)CuCl‐bridged Te2Ru4‐based octahedral cluster chain polymer {[PPh4]2(Te2Ru4(CO)10Cu4Br2Cl2)⋅THF}∞ ({[PPh4]2[4]⋅THF}∞) was produced. The chain polymer {[PPh4]2[4]⋅THF}∞ is the first ternary Te–Ru–Cu cluster and shows semiconducting behavior with a small energy gap of about 0.37 eV. It can be rationalized as resulting from aggregation of doubly CuX‐bridged clusters 1 and 2 with two equivalents of CuCl or CuBr, respectively. The nature of clusters 1–4 and the formation and semiconducting properties of the polymer of 4 were further examined by molecular orbital calculations at the B3LYP level of density functional theory.
On the Mechanism and Stereochemistry of Chiral Lithium‐Carbenoid‐Promoted Cyclopropanation Reactions
Authors: Ke Zhuofeng , Zhou Yubing , Gao Hui , Zhao Cunyuan , Phillips David Lee
Published: May 2007

An investigation into the mechanism and stereochemistry of chiral lithium‐carbenoid‐promoted cyclopropanation reactions by using density functional theory (DFT) methods is reported. Previous work suggested that this type of cyclopropanation reaction may proceed by competition between a methylene‐transfer mechanism and a carbometalation mechanism. In this paper, it is demonstrated that the intramolecular cyclopropanation reactions promoted by chiral carbenoids 1 and 2 proceed by the methylene‐transfer mechanism. The carbometalation mechanism was found to have a much higher reaction barrier and does not appear to compete with the methylene‐transfer mechanism. The Lewis base group does not enhance the carbometalation pathway enough to compete with the methylene‐transfer pathway. The present computational results are consistent with experimental observations for these cyclopropanation reactions. The factors governing the stereochemistry of the intramolecular cyclopropanation reaction by the methylene‐transfer mechanism were examined to help elucidate the origin of the stereoselectivity observed in experiments. Both the directing group and the configuration at the C1 centre were found to play a key role in the stereochemistry. Carbenoid 1 has a chiral C1 centre of R configuration. The Lewis base group directs the cyclization of carbenoid 1 to form a single product. In contrast, the Lewis base group cannot direct the cyclization of carbenoid 2 to furnish a stereoselective product due to the S configuration of the chiral C1 centre in carbenoid 2. This relationship of the stereochemistry to the chiral character of the carbenoid has implications for the design of new efficient carbenoid reagents for stereoselective cyclopropanation.
Microwave‐Assisted Transition‐Metal‐Catalyzed Synthesis of N‐Shifted and Ring‐Expanded Buflavine Analogues
Authors: Appukkuttan Prasad , Dehaen Wim , Van der Eycken Erik
Published: May 2007

Two novel and efficient strategies for the synthesis of hitherto unknown N‐shifted and ring‐expanded buflavine analogues are presented. Construction of the medium‐sized ring system of the title molecules, a difficult task due to the high activation energy needed for the ring‐closure with the additional rigidity imposed by the biaryl skeleton, was achieved by using Suzuki–Miyaura biaryl coupling and a ring‐closing metathesis reaction as the key steps. The combination of a second‐generation Grubbs catalyst and microwave irradiation proved to be highly useful in generating the otherwise difficult to obtain medium‐sized ring system of the buflavine analogues.
Cucurbit[8]uril/Cucurbit[7]uril Controlled Off/On Fluorescence of the Acridizinium and 9‐Aminoacridizinium Cations in Aqueous Solution
Authors: Wang Ruibing , Yuan Lina , Ihmels Heiko , Macartney Donal H.
Published: May 2007

The blue fluorescence of acridizinium bromide (ADZ+) and the green fluorescence of 9‐aminoacridizinium bromide (AADZ+) in aqueous solutions can be almost entirely switched off upon the double inclusion of these guests in the cavity of cucurbit[8]uril (CB[8]) owing to the formation of a nonfluorescent, noncovalent dimer complex, and then fluorescence can be effectively restored by adding cucurbit[7]uril (CB[7]) to the complex because it competitively extracts the fluorophores out of the CB[8] cavity.
Understanding Adsorption and Interactions of Alkane Isomer Mixtures in Isoreticular Metal–Organic Frameworks
Authors: Zhang Li , Wang Qi , Wu Tao , Liu Ying‐Chun
Published: May 2007

Novel metal–organic frameworks (MOFs) may lead to advances in adsorption and catalysis owing to their superior properties compared to traditional nanoporous materials. A combination of the grand canonical Monte Carlo method and configurational‐bias Monte Carlo simulation was used to evaluate the adsorption isotherms of C4–C6 alkane isomer mixtures in IRMOF‐1 and IRMOF‐6. The amounts of adsorbed linear and branched alkanes increase with increasing pressure, and the amount of branched alkanes is larger than that of the linear ones. The locations of the alkane isomer reveal that the Zn4O clusters of the IRMOFs are the preferential adsorption sites for the adsorbate molecules. The interaction energy between the Zn4O cluster and the adsorbate is larger than that between the organic linker and the adsorbate. It was further confirmed that the Zn4O cluster plays a much more important role in adsorption by pushing a probe molecule into the pore at positions closer to the Zn4O cluster. It is difficult for branched alkane molecules to approach the Zn4O cluster of IRMOF‐6 closely owing to strong spatial hindrance. In addition, the adsorption selectivity is discussed from the viewpoints of thermodynamics and kinetics, and the diffusion behavior of n‐butane and 2‐methylpropane were investigated to illustrate the relationship between diffusion and adsorption.
A Sol–Gel‐Modified Poly(methyl methacrylate) Electrophoresis Microchip with a Hydrophilic Channel Wall
Authors: Chen Gang , Xu Xuejiao , Lin Yuehe , Wang Joseph
Published: May 2007

A sol–gel method was employed to fabricate a poly(methyl methacrylate) (PMMA) electrophoresis microchip that contains a hydrophilic channel wall. To fabricate such a device, tetraethoxysilane (TEOS) was injected into the PMMA channel and was allowed to diffuse into the surface layer for 24 h. After removing the excess TEOS, the channel was filled with an acidic solution for 3 h. Subsequently, the channel was flushed with water and was pretreated in an oven to obtain a sol–gel‐modified PMMA microchip. The water contact angle for the sol–gel‐modified PMMA was ≈27.4° compared with ≈66.3° for the pure PMMA. In addition, the electro‐osmotic flow increased from 2.13×10−4 cm2 V−1 s−1 for the native‐PMMA channel to 4.86×10−4 cm2 V−1 s−1 for the modified one. The analytical performance of the sol–gel‐modified PMMA microchip was demonstrated for the electrophoretic separation of several purines, coupled with amperometric detection. The separation efficiency of uric acid increased to 74 882.3 m−1 compared with 14 730.5 m−1 for native‐PMMA microchips. The result of this simple modification is a significant improvement in the performance of PMMA for microchip electrophoresis and microfluidic applications.
Total Synthesis of Five Thapsigargins: Guaianolide Natural Products Exhibiting Sub‐Nanomolar SERCA Inhibition
Authors: Andrews Stephen P. , Ball Matthew , Wierschem Frank , Cleator Ed , Oliver Steven , Högenauer Klemens , Simic Oliver , Antonello Alessandra , Hünger Udo , Smith Martin D. , Ley Steven V.
Published: May 2007

Herein we describe the total synthesis of five guaianolide natural products: thapsigargin, thapsivillosin C, thapsivillosin F, trilobolide and nortrilobolide. Prodrug derivatives of thapsigargin have shown selective in vivo cytotoxicity against prostate tumours and the need for further investigation of this phenomenon highlights the importance of these total syntheses. The first absolute stereochemical assignment of thapsivillosin C is also delineated.
Charge‐Transfer Emission Involving Three‐Coordinate Organoboron: V‐Shape versus U‐Shape and Impact of the Spacer on Dual Emission and Fluorescent Sensing
Authors: Bai Dong‐Ren , Liu Xiang‐Yang , Wang Suning
Published: May 2007

New V‐shaped bifunctional organosilicon compounds that contain an electron acceptor, B(Mes)2, and an electron donor, N(1‐naph)Ph, with the formulae Ph2Si{p‐C6H4B(Mes)2}{p‐C6H4N(1‐naph)ph)} (1), Ph2Si{p‐C6H4(Mes)2}{p‐biphenyl‐N(1‐naph)ph} (2), and Si{p‐C6H4B(Mes)2}2{p‐C6H4N(1‐naph)ph)}2 (3) have been synthesized as model compounds for the investigation of through‐space charge‐transfer emission involving triarylboron and triarylamino centers. The photophysical properties of the new bifunctional organosilicon compounds are compared to two U‐shaped compounds sBN and BN in which the boron acceptor and the amino donor groups are linked together by a rigid 1,10‐naphthyl group. The results of our investigation establish that dual emission pathways, namely through‐space donor‐acceptor charge transfer and π–π* transitions coexist in the V‐shaped molecules 1–3, while charge transfer emission is dominant in the U‐shaped molecules. It is found that depending on the geometry of the linker and the B⋅⋅⋅N separation distance, the compound either displays dual emission bands simultaneously or single emission band. In addition, the dual emission pathways in these molecules can be selectively switched on or off by using fluoride ions. The sensitivity of response to fluoride ions by these molecules is also found to be highly dependent on the geometry of the linker and the B⋅⋅⋅N separation distance. The V‐shaped molecules are found to be “turn‐on” sensors to fluorides with a much higher sensitivity than the U‐shaped molecules.
The Anhydride Route to Group 15/16 Ligands in Oligomeric and Polymeric Environments: From Metal Complexes to Supraionic Chemistry
Authors: Rothenberger Alexander , Shi Weifeng , Shafaei‐Fallah Maryam
Published: May 2007

The aim of this paper is to introduce a synthetic concept suitable for the preparation of a broad variety of compounds. The so‐called anhydride route (in this article the term anhydride is used for compounds derived from corresponding acids by formal loss of H2O, H2S and H2Se) has so far led to a range of unusual Group 15/16 ligands in oligomeric and polymeric environments. Commonly, reactions of neutral precursor molecules, for example, [{RP(S)(μ‐S)}2] (R=4‐anisyl) Lawesson's reagent or [{PhP(Se)(μ‐Se)}2] Woollins's reagent and metal salts are performed to result in novel coordination compounds in which ligands and metal atoms form coordination oligomers and polymers. An attempt is made to relate the outcome of the investigations to the type of metal used. By relating the strength of ionic interactions, which correspond to metal–donor distances, to phenomena observed in the solid‐state structures, an aspect of supraionic chemistry is described. Chemistry of and beyond novel Group 15/16 anions is further discussed using a novel approach in coordination chemistry where the chemical nature of ligands is unknown prior to the experiment despite the use of a range of similar starting materials.
Gold(I)‐Catalyzed 5‐endo Hydroxy‐ and Alkoxycyclization of 1,5‐Enynes: Efficient Access to Functionalized Cyclopentenes.
Authors: Buzas Andrea K. , Istrate Florin M. , Gagosz Fabien
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Intramolecular Acylation of α‐Sulfinyl Carbanions with Masked α,β‐Unsaturated Esters: A General Strategy to 5‐Alkylidene‐2‐cyclopentenones.
Authors: Pohmakotr Manat , Thamapipol Sirinporn , Tuchinda Patoomratana , Reutrakul Vichai
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Efficient Carbon—Sulfur Bond Formation Reaction via Microwave‐Assisted Nucleophilic Substitution of Thiols to Polychloroalkanes Without a Transition‐Metal Catalyst.
Authors: Cao Yi‐Ju , Lai Yuan‐Yuan , Cao Hong , Xing Xiao‐Ning , Wang Xiang , Xiao Wen‐Jing
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Pd(N,N‐Dimethyl β‐alaninate)2 as a High‐Turnover‐Number, Phosphine‐Free Catalyst for the Suzuki Reaction.
Authors: Cui Xin , Qin Tian , Wang Jia‐Rui , Liu Lei , Guo Qing‐Xiang
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Strained 1‐Azabicyclo[1.1.0]butanes in the Synthesis of Azetidinethiocarboxylate Derivatives.
Authors: Woznicka Marta , Urbaniak Katarzyna , Mloston Grzegorz , Heimgartner Heinz
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Propargylation/Cycloisomerization Tandem Process Catalyzed by a Ruthenium(II)/Trifluoroacetic Acid System: One‐Pot Entry to Fully Substituted Furans from Readily Available Secondary Propargylic Alcohols and 1,3‐Dicarbonyl Compounds.
Authors: Cadierno Victorio , Gimeno Jose , Nebra Noel
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Enantioselective Vinylogous Addition of 2‐Trimethylsilyloxyfuran to Aldehydes Promoted by the SiCl4/Chiral Lewis Base System.
Authors: Palombi Laura , Acocella Maria R. , Celenta Nicoletta , Massa Antonio , Villano Rosaria , Scettri Arrigo
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Palladium‐Catalyzed Direct Arylation of Furans via C—H Functionalization at Low Catalyst Loadings.
Authors: Battace Ahmed , Lemhadri Mhamed , Zair Touriya , Doucet Henri , Santelli Maurice
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Butenolide Synthesis by Molybdenum‐Mediated Hetero‐Pauson—Khand Reaction of Alkynyl Aldehydes.
Authors: Adrio Javier , Carretero Juan C.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Antimicrobial Investigation of Some Novel Phenyl Pyrazole, Azetidinone and Diazenyl Ethanone Derivatives of Benzofurans.
Authors: Kumar D. B. Aruna , Prakash G. K. , Kumaraswamy M. N. , Nandeshwarappa B. P. , Sherigara B. S. , Mahadevan K. M.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Highly Selective 5‐Substitution of 3‐Methylthiophene via Directed Lithiation.
Authors: Smith Keith , Barratt Mark Lewis
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Regioselective Cross‐Coupling of 1‐Vinylpyrroles with Acylbromoacetylenes on Al2O3: Synthesis of 2‐(2‐Acylethynyl)‐1‐vinylpyrroles.
Authors: Trofimov B. A. , Sobenina L. N. , Stepanova Z. V. , Ushakov I. A. , Petrova O. V. , Tarasova O. A. , Volkova K. A. , Mikhaleva A. I.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Selective Thiylation of 1‐Vinylpyrrole‐2‐carbaldehydes: Synthesis of the Novel Pyrrole Synthons 2‐[Bis(ethylsulfanyl)methyl]‐1‐vinylpyrroles and 1‐(2‐Ethylthioethyl)pyrrole‐2‐carbaldehydes.
Authors: Vasil'tsov Alexander M. , Ivanov Andrey V. , Ushakov Igor' A. , Mikhaleva Al'bina I. , Trofimov Boris A.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 4,7‐Dihydro‐2H‐isoindole Derivatives via Diels—Alder Reaction of Tosylacetylene.
Authors: Okujima Tetsuo , Jin Guangnan , Hashimoto Yusuke , Yamada Hiroko , Uno Hidemitsu , Ono Noboru
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
The Azaallylic Anion as a Synthon for Pd‐Catalyzed Synthesis of Heterocycles: Domino Two‐ and Three‐Component Synthesis of Indoles.
Authors: Barluenga Jose , Jimenez‐Aquino Agustin , Valdes Carlos , Aznar Fernando
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Properties of Novel Bis(1,3‐benzodithiolium)‐Type Dications Containing a Biaryl Unit: New Redox Systems Undergoing Reversible Structural Changes by Electron Transfer.
Authors: Ohta Akira , Ueki Chihiro , Uchiyama Yuzuru , Fujimori Kunihide
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Iminophosphorane‐Based Approach for the Synthesis of Spiropyrrolidine—Imidazole Derivatives.
Authors: Fresneda Pilar M. , Castaneda Marta , Sanz Miguel Angel , Bautista Delia , Molina Pedro
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient and Highly Regioselective Direct C‐2 Arylation of Azoles, Including Free (NH)‐Imidazole, ‐Benzimidazole and ‐Indole, with Aryl Halides.
Authors: Bellina Fabio , Calandri Chiara , Cauteruccio Silvia , Rossi Renzo
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Facile Synthesis of 2‐Acyl and 2‐Alkylaminobenzimidazoles for 5‐Lipoxygenase Inhibitors.
Authors: Lee Jin Ha , An Mi Hyun , Choi Eun Hyun , Choo Hea‐Young Park , Han Gyoonhee
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Improved Method for the Preparation of 2‐(2′‐Aminoaryl)oxazolines from Substituted Isatoic Anhydrides and 2‐Chloroethylamine Hydrochloride.
Authors: Hunt David A.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Novel Synthesis of Some 2‐Imino‐4‐thiazolidinone Derivatives
Authors: Moghaddam Firouz Matloubi , Hojabri Leila
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Efficient and Rapid Synthesis of 1‐Substituted‐1H‐1,2,3,4‐tetrazoles in the Acidic Ionic Liquid 1‐n‐Butylimidazolium Tetrafluoroborate.
Authors: Potewar Taterao M. , Siddiqui Shafi A. , Lahoti Rajgopal J. , Srinivasan Kumar V.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of 3‐Alkylcoumarins from Salicylaldehydes and α,β‐Unsaturated Aldehydes Utilizing Nucleophilic Carbenes: A New Umpoled Domino Reaction.
Authors: Toraeng Jakob , Vanderheiden Sylvia , Nieger Martin , Braese Stefan
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Reaction of 2H‐Cyclohepta[b]furan‐2‐ones with Pyridinium Salts of Trifluoromethanesulfonic Anhydride.
Authors: Morita Noboru , Matsuki Tomohiro , Nakashima Masashi , Shoji Taku , Toyota Kozo , Kikuchi Shigeru , Ito Shunji
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Pharmacological Study of Thiazolidinones and Mannich Bases of 4‐Amino‐3‐mercapto‐5‐pyridin‐3′‐yl‐[1,2,4]‐triazole.
Authors: Dave T. K. , Purohit D. H. , Akbari J. D. , Joshi H. S.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Microwave‐Assisted Synthesis of 2‐(2‐Pyridyl)azoles. Study of Their Corrosion Inhibiting Properties.
Authors: Likhanova Natalya V. , Veloz M. Aurora , Hoepfl Herbert , Matias Diana J. , Reyes‐Cruz Victor E. , Olivares Octavio , Martinez‐Palou Rafael
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
4‐Aryl‐2‐quinolones via a Domino Heck Reaction/Cyclization Process.
Authors: Bernini Roberta , Cacchi Sandro , Fabrizi Giancarlo , Sferrazza Alessio
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Polyhydroquinoline Derivatives Through Unsymmetric Hantzsch Reaction Using Organocatalysts.
Authors: Kumar Atul , Maurya Ram Awatar
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Acridone Heterocycles as Fluorescent Sensors for Anions.
Authors: Blazquez M. Teresa , Muniz Francisco M. , Saez Silvia , Simon Luis M. , Alonso Angel , Raposo Cesar , Lithgow Anna , Alcazar Victoria , Moran Joaquin R.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis of Novel Triazole, Quinoline, Oxazole and Imidazole Annulated Carbostyrils by Microwave Irradiation.
Authors: Dabholkar Vijay V. , Parab Sagar D.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
An Efficient Synthesis of Isoindolo[2,1‐a]quinoline Derivatives via Imino Diels—Alder and Intramolecular Diels—Alder Reactions with Furan.
Authors: Kouznetsov Vladimir V. , Cruz Uriel Mora , Zubkov Fedor I. , Nikitina Eugenia V.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and Structure Elucidation of 3,4‐Dihydroxy‐2‐quinolin‐2‐ylpyrido[3,2,1‐jk]carbazol‐6‐ones.
Authors: Dang Hoai V. , Habib Nargues S. , Kappe Thomas , Zangger Klaus , Stadlbauer Wolfgang
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Studies with Enamines and Azaenamines: A Novel Efficient Route to 6‐Amino‐1,4‐dihydropyridazines and Their Condensed Derivatives.
Authors: Ghozlan Said A. S. , Abdelhamid Ismail A. , Hassaneen Hamdi M. , Elnagdi Mohamed H.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Highly Efficient and Selective Route to Isomeric Cyclic Diazadienes.
Authors: Scott Mark E. , Bethuel Yann , Lautens Mark
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
One‐Step Synthesis of 4,5‐Disubstituted Pyrimidines Using Commercially Available and Inexpensive Reagents.
Authors: Baran Phil S. , Shenvi Ryan A. , Nguyen Steven A.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
N‐Substituted Ureas and Thioureas in Biginelli Reaction Promoted by Chlorotrimethylsilane: Convenient Synthesis of N1‐Alkyl‐, N1‐Aryl‐, and N1,N3‐Dialkyl‐3,4‐dihydropyrimidin‐2(1H)‐(thi)ones.
Authors: Ryabukhin Sergey V. , Plaskon Andrey S. , Ostapchuk Eugeniy N. , Volochnyuk Dmitriy M. , Tolmachev Andrey A.
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
New Three‐Component Cyclocondensation Reaction: Microwave‐Assisted One‐Pot Synthesis of 5‐Unsubstituted‐3,4‐dihydropyrimidin‐2(1H)‐ones under Solvent‐Free Conditions.
Authors: Liang Bing , Wang Xitian , Wang Jin‐Xian , Du Zhengyin
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
C‐Functionalization of 9‐Deazapurines by Cross‐Coupling Reactions.
Authors: Bambuch Vitezslav , Otmar Miroslav , Pohl Radek , Masojidkova Milena , Holy Antonin
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A New Useful Conversion Method of Naltrexone to 14‐Deoxynaltrexone.
Authors: Osa Yumiko , Ida Yoshihiro , Yano Yumiko , Furuhata Kimio , Nagase Hiroshi
Published: May 2007

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Die Konstanz der Phänomene und der Wandel ihrer Deutung
Authors: Reiners Christiane S.
Published: May 2007

WIR GLAUBEN DANN ein jegliches zu erkennen, wenn wir die ersten Ursachen und die ersten beherrschenden Anfänge bis zu den Elementen erkannt haben. (Aristoteles. Die ontologischen Grundlagen der Paideia).
1,2‐Mannobioside Mimic: Synthesis, DC‐SIGN Interaction by NMR and Docking, and Antiviral Activity
Authors: Reina José J. , Sattin Sara , Invernizzi Donatella , Mari Silvia , Martínez‐Prats Lorena , Tabarani Georges , Fieschi Franck , Delgado Rafael , Nieto Pedro M. , Rojo Javier , Bernardi Anna
Published: May 2007

The design and preparation of carbohydrate ligands for DC‐SIGN is a topic of high interest because of the role played by this C‐type lectin in immunity and infection processes. The low chemical stability of carbohydrates against enzymatic hydrolysis by glycosylases has stimulated the search for new alternatives more stable in vivo. Herein, we present a good alternative for a DC‐SIGN ligand based on a mannobioside mimic with a higher enzymatic stability than the corresponding disaccharide. NMR and docking studies have been performed to study the interaction of this mimic with DC‐SIGN in solution demonstrating that this pseudomannobioside is a good ligand for this lectin. In vitro studies using an infection model with Ebola pseudotyped virus demonstrates that this compound presents an antiviral activity even better than the corresponding disaccharide and could be an interesting ligand to prepare multivalent systems with higher affinities for DC‐SIGN with potential biomedical applications.
Outcomes in patients with primary breast cancer and a subsequent diagnosis of endometrial cancer
Authors: Saadat Mandana , Truong Pauline T. , Kader Hosam A. , Speers Caroline H. , Berthelet Eric , McMurtrie Elissa , Olivotto Ivo A.
Published: May 2007

BACKGROUND.

The study compared tumor characteristics and survival in women with breast cancer who subsequently developed endometrial cancer with or without a history of tamoxifen use.

METHODS.

The British Columbia Cancer Agency registry identified 163 women diagnosed with breast cancer between 1989–1999 who received a subsequent diagnosis of endometrial cancer. Of these, 55% (n = 90) had a history of tamoxifen use. Outcomes analyzed were breast cancer‐specific survival (BCSS), endometrial cancer‐specific survival (ECSS), and overall survival (OS).

RESULTS.

Median follow‐up was 9.4 years. Distributions of age, menopausal status, body mass index, and comorbidities were similar in the tamoxifen‐treated and nontamoxifen cohorts. Proportions of aggressive endometrial cancer subtypes including papillary serous, clear cell, and mixed mullerian tumors were higher in the tamoxifen cohort (28% vs14%, P = .03). Distributions of endometrial cancer grade and stage were similar in the 2 groups (P > .05). Hysterectomy and/or oophorectomy were the primary treatments for endometrial cancer in 99% of patients, with comparable pelvic control rates in the tamoxifen and nontamoxifen groups. At 10 years, patients in the tamoxifen group experienced lower BCSS compared with the nontamoxifen group (89% vs 97%, P = .02). No significant differences in ECSS and OS were observed between the 2 groups (ECSS 82% and 82%, P = .85; and OS 69% v. 66%, P = .85).

CONCLUSIONS.

In patients with breast cancer who developed a subsequent endometrial cancer, tamoxifen‐treated patients had higher proportions of aggressive endometrial cancer subtypes, but almost all cases were amenable to surgery, thus resulting in similar endometrial cancer control and survival when compared with nontamoxifen treated patients. Cancer 2007. © 2007 American Cancer Society.
Determination of the Geometry Change of the Phenol Dimer upon Electronic Excitation
Authors: Brause Robert , Santa Monika , Schmitt Michael , Kleinermanns Karl
Published: May 2007

The change of the phenol dimer (PH2) structure upon electronic excitation is determined by a Franck–Condon analysis of the intensities in the ﬂuorescence emission spectra obtained via excitation of seven different vibronic bands. A total of 547 emission band intensities are ﬁtted, together with the changes of rotational constants upon electronic excitation of ﬁve isotopomers. These rotational constants are taken from previously published [Schmitt et al. ChemPhysChem 2006, 7, 1241–1249] high‐resolution LIF measurements. The geometry change upon electronic excitation of the ππ* state of the donor moiety can be described by a strong shortening of the hydrogen bond, a shortening of the CO bond in the donor moiety, an overall symmetric expansion of the donor phenol ring, and a nearly unchanged acceptor moiety. The resulting geometry changes are interpreted on the basis of ab initio calculations.
National sustainable development strategies: features, challenges and reflexivity
Authors: Meadowcroft James
Published: May 2007

More than a decade has passed since the first countries issued national sustainable development strategies. This essay will consider recent developments in this area, and explore the extent to which such strategies can be considered an emergent mode of reflexive governance of the type required to promote sustainable development. The argument involves three steps: first, a review of the current state of play with respect to sustainable development strategies; second, an assessment of existing strategy processes, and third, a more theoretically focused discussion of their potential significance. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
Pursuing sustainable development in Norway: the challenge of living up to Brundtland at home
Authors: Lafferty William M. , Knudsen Jørgen , Larsen Olav Mosvold
Published: May 2007

With the Norwegian Prime Minister, Gro Harlem Brundtland, as chair of the World Commission on Environment and Development, Norway became an early mover in politics for sustainable development (SD). The pursuit of SD goals has been expressed in several national policy documents, though it was not until 2002 that Norway adopted an explicit ‘National Strategy for Sustainable Development’. This was followed up by a ‘National Action Plan for Sustainable Development’ in 2003. Neither of these initiatives has been actively implemented, and both are now being evaluated and revised by the current ‘red–green’ coalition government. The article presents and assesses strategic SD initiatives from 1989 to the present day. The major conclusion of the analysis is that the Norwegian SD profile is ‘long on promise’ and ‘short on delivery’, and that one major reason for this is the influence of a booming petroleum economy on distributional politics. An exceptional growth in public revenues due to oil and gas fosters intense political competition over the dispensation of economic and welfare benefits – both between political parties and within governing coalitions – and undermines the ‘political will’ to pursue the SD agenda. Given the ability to also use the surplus for development assistance, Norway stands forth as an SD ‘frontrunner’ in international aid, and an SD ‘laggard’ in sustainable production and consumption at home. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
From government strategies to strategic public management: an exploratory outlook on the pursuit of cross‐sectoral policy integration
Authors: Steurer Reinhard
Published: May 2007

This paper discusses how public administrations handle cross‐sectoral government strategies such as those on sustainable development (SD), and how this could (or should) change in the future. It puts SD strategies and their key objective of improving the cross‐sectoral integration of policies into the wider context of public administration in two respects. In a first step, the paper shows that SD strategies are a progressive step in the protracted debate on planning and strategic management in the public sector. In a second step, however, the paper explores the functioning of specialized public administrations as one explanation for the shortcomings of SD strategies in Europe. Consequently, the paper concludes that SD strategies should be developed further into a tool of strategic public management that helps to adapt administrative approaches to the integrative challenges of SD. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
The German sustainable development strategy: facing policy, management and political strategy assessments
Authors: Tils Ralf
Published: May 2007

The Germans' conviction of being an international frontrunner in environmental policy stands in contrast to the unwillingness of the German national governments of the 1990s to undertake a commitment for a nationwide sustainable development strategy. Using five core strategy categories, namely horizontal and vertical integration, participation, implementation mechanism, monitoring and evaluation, this article provides an overview of the German sustainable development strategy preparation and implementation process. While the strategy is an ambitious concept, it also exhibits important shortcomings when viewed with different analytical perspectives such as policy, management and political strategy. Only with all of these perspectives combined can we arrive at specific conclusions about the assessment of the strategy process and make the essential characteristics of political strategy apparent. Copyright © 2007 John Wiley & Sons, Ltd and ERP Environment.
From Genes to Metalloproteins: A Bioinformatic Approach
Authors: Bertini Ivano , Rosato Antonio
Published: May 2007

Genome sequencing projects have provided researchers with detailed information on every gene present in a large variety of organisms. Each of these genes is responsible for producing one or more proteins (depending on processes such as alternative splicing and post‐translational modification) that constitute the machineries needed to sustain cellular life. The ensemble of proteins that an organism is capable of producing is called the proteome. A significant share of each organism's proteome requires metal ions or metal‐containing cofactors to carry out its physiological function (metalloproteome). Experimental methods for the characterization of the metalloproteome of even simple prokaryotic organisms are still not routinely available, therefore significant insights can currently be only obtained using bioinformatic approaches. Herein we review the results obtained from the bioinformatic analyses of a variety of organisms, including humans, in which the distribution of iron‐, copper‐, and zinc‐binding proteins across the kingdoms of life were investigated. It was found that among the metals, zinc is required by the largest number of proteins in most organisms (on average, 10 % of the proteome in eukaryota is predicted to be zinc‐binding), whereas copper is the least common. In addition, the majority of non‐heme iron‐binding proteins have homologs in each taxonomic domain (archaea, bacteria, eukaryota), whereas zinc‐ and copper‐binding proteins are substantially differentiated in eukaryota with respect to prokaryotic organisms. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Coordination Versatility of 5(3)‐(2‐Hydroxyphenyl)‐3(5)‐methylpyrazole: Synthesis, Crystal Structure and Properties of CoIII, NiII and CuII Complexes
Authors: Viciano‐Chumillas Marta , Tanase Stefania , Aromí Guillem , Smits Jan M. M. , de Gelder René , Solans Xavier , Bouwman Elisabeth , Reedijk Jan
Published: May 2007

New complexes with 5(3)‐(2‐hydroxyphenyl)‐3(5)‐methylpyrazole (H2phpz), [Co2(H2phpz)(Hphpz)2(phpz)2]·3CH3CN (1), [Ni(Hphpz)2] (2) and [Cu(Hphpz)2] (3), were synthesized and structurally characterized. The ligand coordinates in the form of 3‐(2‐hydroxyphenyl)‐5‐methylpyrazole in all cases, except for one ligand in the CoIII complex, where it coordinates in the 5‐(2‐hydroxyphenyl)‐3‐methylpyrazole mode. Crystallographic analysis revealed that 1 contains two chemically and crystallographically distinct cobalt(III) ions triply bridged by one phenoxide and two pyrazolate groups, giving rise to a [Co2(N‐N)2O] core with a Co···Co distance of 3.154 Å. Additionally, the H2phpz ligand shows four different coordination modes with the metal ions, demonstrating its versatility. The dinuclear unit of 1 is stabilized by strong intramolecular N–H···O hydrogen‐bonding interactions involving the phenol oxygen atom of the H2phpz ligand and the N–H functionality of the pyrazole ring. The crystal structure of the isomorphous complexes 2 and 3 reveals the presence of centrosymmetric mononuclear units with the MN2O2 [M = NiII (2), CuII (3)] chromophore displaying a slightly distorted square‐planar geometry. The mononuclear structures of 2 and 3 are further stabilized by intramolecular hydrogen bonds established between the acid N–H group as donor and the phenoxide group of the H2phpz ligand as acceptor. Spectroscopic studies, ESI‐MS and cyclic voltammetry were performed, supporting the crystallographic analysis. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
Determination of tocopherols and phytosterols in sunflower seeds by NIR spectrometry
Authors: Gotor Alicia Ayerdi , Farkas Eric , Berger Monique , Labalette Françoise , Centis Sylvie , Daydé Jean , Calmon Anne
Published: May 2007

The objective of this work was to develop a near‐infrared reflectance spectrometry (NIRS) calibration estimating the tocopherol and phytosterol contents in sunflower seeds. Approximately 1000 samples of grinded sunflower kernels were scanned by NIRS at 2‐nm intervals from 400 to 2500 nm. For each sample, standard measurements of tocopherol and phytosterol contents were performed. The total tocopherol content was obtained by high‐performance liquid chromatography coupled with a fluorescence detector, while the total phytosterol content was assessed by gas chromatography. For tocopherol, the calibration data set ranged from 175 to 1005 mg/kg oil (mean value around 510 ± 140 mg/kg oil), whereas for the phytosterol content, the calibration data set ranged from 180 to 470 mg/100 g oil (mean value of 320 ± 50 mg/100 g oil). The NIRS calibration showed a relatively good correlation (R2 = 0.64) between predicted by NIRS and real values for the total tocopherol content but a poor correlation for the total phytosterol content (R2 = 0.27). These results indicate that NIRS could be useful to classify samples with high and low tocopherol content. In contrast, the estimation of phytosterol contents by NIRS needs further investigation. Moreover, in this study, calibration was obtained by a modified partial least‐squares method; the use of other mathematical treatments can be suitable, particularly for total phytosterol content estimation.
Instrumental technique evolution for olive oil sensory analysis
Authors: Escuderos María Elena , Uceda Marino , Sánchez Sebastián , Jiménez Antonio
Published: May 2007

At present, two systems have been usually used to identify olive oil aroma: the official panel test, according to the European Union Regulation [1], and the gas chromatographic method and its improvements. However, both types of techniques have two principal disadvantages: They need a long time for analysis and cannot be applied on‐line. Recently, there has been increasing interest in the development of a new device, the so‐called “electronic nose”. The aim of this work is to perform both a review of these techniques used for olive oil sensory analysis and their advantages and disadvantages.
In‐process monitoring in industrial olive mill by means of FT‐NIR
Authors: Bendini Alessandra , Cerretani Lorenzo , Di Virgilio Fabio , Belloni Paolo , Lercker Giovanni , Toschi Tullia Gallina
Published: May 2007

A total of 287 olive lots and 161 olive oil samples were analyzed for fat content, moisture and free acidity, using a Fourier transform near‐infrared (FT‐NIR) instrument located in an industrial mill. Samples having a wide range of both reference values and olive lot sizes (from <0.5 to >4 t) were collected at three industrial mill plants, located in the same Italian region, which utilize different technological equipment for virgin olive oil production. Olive paste spectra were acquired in diffuse reflectance, while oil samples were measured in transmission. Calibration models for oil content and moisture of olives as well as free acidity of virgin olive oils were developed using partial least squares (PLS) regression, first derivative and straight line subtraction. Results of calibration and validation of the PLS models selected were good. The PLS results indicate good similarity between data obtained from FT‐NIR and reference laboratory methods, allowing a rapid and less expensive screening analysis. Unfortunately, the correlation between the oil yield values recorded for all olive lots at the industrial mills and the oil content predicted by FT‐NIR was not satisfactory (R2 = 0.605).