bluuebunny/crossref_metadata_2025 huggingface dataset:
Marcel Proust in the “great time” of historical poetics (based on the works of S. N. Broitman and A. V. Mikhailov)
Authors: Danilina Galina I.
Published: February 2023

This article presents the result of studying M. Proust’s novel from the perspective of the historical poetics scientific school. The research material is based on S. N. Broitman’s “Historical Poe­tics” (2004) and A. V. Mikhailov’s “Methods and Styles of Literature” (1980s), “The Character Problem in Art: Painting, Sculpture, Music” (1988). The research problem is based on Bakhtin’s “Great Time” idea. The author shows how S. N. Broitman uses this idea while analyzing M. Proust’s “In Search of Lost Time”, namely, the ways and the results of the “Great Time” idea implementation. Bakhtin represents “dialogue in the Great Time” as a conversation between “I and the other, the author and the character”, besides, he separates compositional and architectonic forms. Based on these ideas, S. N. Broitman reveals the architectonic novelty of Proust’s novel: the intersubjectivity of the author and the hero, the unsteady plot, and the revival of the ancient poetic imagery. The other way of analyzing Proust’s novel is realized in A. V. Mikhailov’s conception. It is aimed at revealing the process of rethinking the keywords of culture in the “Great Time” of historical poetics. In Mikhailov’s opinion, “Personality” and “Character” are the most significant, representative keywords as far as in Proust’s times the process of their rethinking was completed. It has led to the birth of a new “I” and its new relationships with the time and the environment. According to Mikhailov’s logic, the meaning of “In Search of Lost Time” is fundamental in this regard, and the article reveals what this value consists of. There is one more aspect in Mikhailov’s conception the author of the article pays attention to. The researcher considers his methodology of analyzing transitional language of culture and art at the turn of the 19th-20th centuries as a perspective way of Proust’s novel research. In Broitman’s concept, the novelty of Proust’s works is revealed at the level of the depicted world structure (author-character, plot, syncretic imagery), in Mikhailov’s concept, the one is revealed by the world depicting (“I” and the new poetics of the time). This proves creative productivity of Bakhtin’s ideas for a multilateral study of Proust’s novel in the light of historical poetics.
Aftertext as a system (case of Anna Akhmatova)
Authors: Menshchikova Anna M.
Published: February 2023

This article attempts to study Anna Akhmatova’s aftertext as a system of interrelated elements, determined by the artistic consciousness and creative strategy of the poet. The comparison of texts of various genres and the analysis of the contextual field in each case show that the poet intentionally created intersections at the levels of structure, plots, images from the autobiographical book of prose “Pages from the Diary”, as well as “Prose about the Poem”, epistolary heritage, and “Notebooks”. The variability of the studied texts, which often exist on the principle of “duality”, as well as the interpenetrability of the boundaries of aftertext forms and Akhmatova’s artistic heritage are the most vivid manifestations of aftertext’s poetics. The latter shows the author’s desire to express the global unity. Reflecting on the tragic fate of the generation of the “non-calendar 20th century”, exposing false images of her own fate and asserting genuine ones in their place, passing a verdict on her own epoch and consolidating the memory of contemporaries, Akhmatova brings together aftertext and her later works. Therefore, the forms of self-reflection, which developed in parallel with the works of the 1950s and 1960s, reveal the property of fundamental incompleteness.
Book topic in the novel by F. M. Dostoevsky “The Brothers Karamazov”
Authors: Bondarchuk Elena M.
Published: February 2023

The article is devoted to the study of the poetics of F. M. Dostoevsky’s novel “The Brothers Karamazov”. This problematic area, despite active research attention, still contains a huge potential for further discoveries. The author focuses attention on the actual problem of subject-material representation of artistic space. This work aims is to study book topics, to identify a system of relationships between stable images and motives, which are represented in the text as the lexeme “book” and its derivatives. Based on predecessors’ studies (A. P. Vlaskin, G. Ya. Galagan, L. V. Karasev, N. A. Makaricheva), the author puts forward and defines the idea of the functioning of the “ontological scheme” of the plot, which is formed by the subject-symbol “book”. Despite the relative paucity of plot situations with the point of presence of the book, a wide branching of the scheme is revealed, because of the principle of duality inherent in Dostoevsky’s poetics as well. In conclusion, the author argues about the significance of this “ontological scheme” for understanding the idea of the novel in connection with the breadth of the semantics contained in it: knowledge, memory, enlightenment, change, “second birth”. The article consists of four parts, which examine in detail the functioning of the book topic in different plot fragments: in the preface “From the Author”, in the narrator’s reports about the biography of Smerdyakov and Krasotkin, in the third meeting of Ivan Karamazov with Smerdyakov. The author uses the structural-semiotic method of studying the text with elements of mythopoetic and ontological approaches.
Постковидное цветовосприятие: влияние COVID-19 на выбор цветонаименования
Authors: Грибер Юлия А. , Парамей Галина В.
Published: February 2023

Введение. В последнее время появляется всё больше данных о том, что у перенесших COVID-19 наблюдаются различные симптомы нарушения работы зрительной системы. Мы предположили, что у них также может меняться цветовосприятие, вызывая изменения паттерна называния цветов. Чтобы проверить эту гипотезу, мы сравнили цветонаименование людей, выздоровевших после COVID-19 (N = 201, 54 мужчины и 147 женщин в возрасте от 19 до 65 лет, M = 33,4, SD = 13,2), и тех, чьи ответы были получены до пандемии (далее – здоровая контрольная группа) (N = 2457, 1052 мужчины и 1402 женщины в возрасте 16–98 лет, M = 41,36, SD = 17,7). Методы. Данные собирались в ходе онлайн-эксперимента (http://colournaming.com). Участникам в случайном порядке предъявлялись виртуальные цветовые карточки, отобранные компьютерной программой из 606 стимулов, и предлагалось назвать каждый цвет, используя наиболее подходящий цветовой дескриптор (метод свободного называния цветов). Результаты. Исследование показало, что, по сравнению со здоровой контрольной группой, участники, переболевшие COVID-19, действительно используют измененную модель называния цвета: у них заметно увеличивается частота «коричневых», «зеленых» и «серых» цветонаименований, а также отмечается более частое использование ахроматических модификаторов «грязный», «бледный», «тусклый» и «пастельный». Обсуждение результатов. Эти различия указывают на общее «потемнение» и снижение насыщенности воспринимаемых цветов. Изменение модели цветонаименования является косвенным доказательством влияния коронавируса на цветовое зрение. А именно: относительно высокая частота цветонаименований «коричневый» и «серый» может отражать ускоренное старение хрусталика, а феномен «потемнения» и снижения насыщенности может свидетельствовать о нарушении обработки пространственного контраста яркости. Эти предположения в настоящее время проверяются авторами экспериментально с применением тестовой диагностики цветового зрения у лиц, перенесших COVID-19.
Специфика глазодвигательной активности у детей с нарушением слуха в процессе самостоятельного и совместного со взрослым выполнения обучающего задания
Authors: Смирнова Яна К.
Published: February 2023

Введение. Переходный статус выборки детей с нарушением слуха после кохлеарной имплантации расширяет возможности изучения последствий нарушения отдельных сенсорных систем, влияющих на дефицит совместного внимания. Метод регистрации движения глаз имеет преимущества для изучения трудностей процессов обучения детей с нарушением слуха. Новизна исследования заключается в синхронном отслеживании движений глаз с наложенными путями взгляда двух участников эксперимента (взрослого и ребёнка с нарушением слуха) в ситуации обучения и использовании маркера времени одновременных фиксаций как показателя совместного внимания. На основании данных глазодвигательной активности при самостоятельном и синхронном со взрослым выполнении учебного задания может быть выделена специфика визуального внимания, препятствующие обучению детей с нарушением слуха. Методы. Выборка исследования: 16 дошкольников с нарушением слуха (сенсоневральной тугоухостью, класс H90 по МКБ-11) и 16 типично развивающихся детей. Задействованы экспериментальные ситуации самостоятельного и синхронного выполнения со взрослым учебного задания. Основным методом стал метод регистрации движения глаз портативным айтрекером PLabs. Результаты. В глазодвигательной активности у детей с нарушением слуха при синхронном со взрослым выполнении задания увеличивается количество фиксаций, свидетельствующих о постоянном совместном внимании (от 300 миллисекунд), наблюдаются большая релевантность фиксаций и увеличение продолжительности поддержания визуального внимания к учебным образцам, в результате – снижение ошибок. В сравнении с типично развивающимися детьми, у детей с нарушением слуха меняется скорость обработки информации и выделения целевых стимулов. Обсуждение результатов. В эпизодах совместного внимания в ситуации обучения синхронность взаимодействия ребенка с нарушением слуха и взрослого достигается за счет фиксаций длительностью от 300–500 и выше 500 миллисекунд (мс). Однако способность поддерживать такое совместное внимание у детей с нарушением слуха ниже, чем у типично развивающихся сверстников.
Мотивация к успеху учащихся в малых группах при обучении музыке
Authors: Макарова Елена А. , Макарова Елена Л. , Денисов Борис В.
Published: February 2023

Введение. Научная новизна исследования состоит в описании феноменологии малых групп, под которой понимается описание основных явлений, возникающих в сфере взаимоотношений и характерных для малых групп, психологических особенностей формирования мотивации успеха, а также сравнительный анализ результатов анкетирования по формированию мотивации у российских и китайских учащихся. Методы. Анкетирование проводилось с помощью методики, составленной для оценки мотивации к успеху у учащихся малых групп. Адаптированная анкета состоит из вопросов методики социально-психологического исследования малых групп А. В. Сидоренкова и из вопросов зарубежных опросников, посвященных исследованию социальной лености в малой группе. Респондентами были китайские и российские студенты, что позволило провести сравнительный анализ. Целью исследования было получение двух массивов экспериментальных данных по исследуемым показателям, на основании которых был проведен анализ различий между ними. Статистический анализ данных включал вычисление средних величин показателей, а также оценку статистической значимости выявленных различий. Результаты. Проведено комплексное экспериментально-диагностическое исследование по формированию мотивационного процесса учащихся при работе в малых группах в процессе обучения музыке. Результаты исследования выявили социально-психологические противоречия, однако было также доказано, что все три группы респондентов имеют позитивные отношения внутри группы, нуждаются в социальной поддержке. Вторая часть эмпирического исследования оценивала уровень социальной лености при групповом участии в музыкальных занятиях и показала относительно низкий уровень социальной лености в малых группах среди китайских учащихся, более высокий – у российских студентов. Обсуждение результатов. В результате проведенного исследования представлен сравнительный анализ психологической диагностики сформированности мотивации к успеху учащихся при работе в малых группах в процессе обучения музыке в Шэньчжэньском колледже международного образования (Китай), Ростовской государственной консерватории им. С. В. Рахманинова и Таганрогском музыкальном колледже (Россия).
Type 2 Diabetes and HDL Dysfunction: A Key Contributor to
Glycemic Control
Authors: Rotllan Noemi , Julve Josep , Escolà-Gil Joan Carles
Published: February 2023

High-density lipoproteins (HDL) have been shown to exert multiple cardioprotective
and antidiabetic functions, such as their ability to promote cellular cholesterol efflux
and their antioxidant, anti-inflammatory, and antiapoptotic properties. Type 2 diabetes
(T2D) is usually associated with low high-density lipoprotein cholesterol (HDL-C)
levels as well as with significant alterations in the HDL composition, thereby impairing its
main functions. HDL dysfunction also negatively impacts both pancreatic β-cell function
and skeletal muscle insulin sensitivity, perpetuating this adverse self-feeding cycle. The
impairment of these pathways is partly dependent on cellular ATP-binding cassette transporter
(ABC) A1-mediated efflux to lipid-poor apolipoprotein (apo) A-I in the extracellular
space. In line with these findings, experimental interventions aimed at improving HDL
functions, such as infusions of synthetic HDL or lipid-poor apoA-I, significantly improved
glycemic control in T2D patients and experimental models of the disease. Cholesteryl
ester transfer protein (CETP) inhibitors are specific drugs designed to increase HDLC
and HDL functions. Posthoc analyses of large clinical trials with CETP inhibitors have
demonstrated their potential anti-diabetic properties. Research on HDL functionality and
HDL-based therapies could be a crucial step toward improved glycemic control in T2D
subjects.
A Review on the Synthesis and Anticancer Potentials of Imidazothiazole
Derivatives
Authors: Kamboj Payal , Mahore Anjali , Husain Asif , Shaquiquzzaman Mohammad , Alam M. Mumtaz , Amir Mohammad
Published: February 2023

Cancer is one of the severe diseases in which abnormal cells divide and proliferate in an
uncontrolled manner without any regulation. Globally cancer is among the leading causes of death;
according to a recent report of by the WHO, around 10 million people died in 2018 due to cancer. It
has also been reported that by 2040, approximately 30 million new cases will be reported every year.
The increase in the incidences of cancer is taking a toll on the health care system worldwide.
Considerable scientific literature is available on anticancer agents but newer therapeutic strategies are
still required in this field to address novel approaches to drug design and discovery to counter this
problem. Imidazothiazole represents a privileged scaffold in medicinal chemistry and provides the
medicinal chemist the possibility to modulate the physiochemical properties of the lead compound. In
recent times, imidazothiazole scaffold is broadly explored for its anticancer activity, which acts
through various mechanisms such as EGFR, B-RAF, DHFR kinase inhibition and tubulin polymerization
inhibition and other molecular mechanisms of action. Due to their feasible synthetic accessibility
and promising pharmacological profile, it has attracted various medicinal chemists to explore and develop
imidazothiazole derivatives as potent and safe anticancer agents. In the present article, we have
reviewed various potent imidazothiazole scaffold-based derivatives reported as anticancer agents,
their synthetic strategies, Structure Activity Relationship (SAR), mechanism of action, and molecular
docking along with their future perspective. This review will be very useful for medicinal chemists for
drug design and development of imidazothiazole-based potent antiproliferative agents.
Micro-fragmented Fat Inhibits the Progression of Human Mesothelioma
Xenografts in Mice
Authors: La Monica Silvia , Coccé Valentina , Bonelli Mara , Alessandri Giulio , Alfieri Roberta , Lagrasta Costanza Annamaria , Frati Caterina , Flammini Lisa , Gianni Aldo , Petrella Francesco , Paino Francesca , Pessina Augusto
Published: February 2023

Background:

Malignant pleural mesothelioma is a pathology with no effective therapy and
a poor prognosis. Our previous study demonstrated an in vitro inhibitory effect on mesothelioma cell
lines of both the lysate and secretome of adipose tissue-derived Mesenchymal Stromal Cells. The inhibitory
activity on tumor growth has been demonstrated also in vivo: five million Mesenchymal Stromal
Cells, injected “in situ”, produced a significant therapeutic efficacy against MSTO-211H xenograft
equivalent to that observed after the systemic administration of paclitaxel.

Objective:

The objective of this study is to evaluate the efficacy of low amount (half a million) Mesenchymal
Stromal Cells and micro-fragmented adipose tissues (the biological tissue from which the Mesenchymal
Stromal Cells were isolated) on mesothelioma cells growth.

Methods:

Tumor cells growth inhibition was evaluated in vitro and in a xenograft model of mesothelioma.

Results:

The inhibitory effect of micro-fragmented fat from adipose-tissue has been firstly confirmed
in vitro on MSTO-211H cell growth. Then the efficacy against the growth of mesothelioma xenografts
in mice of both micro-fragmented fat and low amount of Mesenchymal Stromal Cells has been evaluated.
Our results confirmed that both Mesenchymal Stromal Cells and micro-fragmented fat, injected
“in situ”, did not stimulate mesothelioma cell growth. By contrast, micro-fragmented fat produced a
significant inhibition of tumor growth and progression, comparable to that observed by the treatment
with paclitaxel. Low amount of Mesenchymal Stromal Cells exerted only a little anticancer activity.

Conclusion:

Micro-fragmented fat inhibited mesothelioma cell proliferation in vitro and exerted a significant
control of the mesothelioma xenograft growth in vivo.
Tumor-associated Macrophages (TAMs) in Cancer Resistance; Modulation
by Natural Products
Authors: Lafta Holya A. , AbdulHussein Ali H. , Al-Shalah Saif A. J. , Alnassar Yasir S. , Mohammed Naseer M. , Akram Sally M. , Qasim Maytham T. , Najafi Masoud
Published: February 2023

Tumor-associated macrophages (TAMs) play a pivotal role in the progression and re-sistance of tumors to different anticancer drugs. TAMs can modulate the tumor microenvironment (TME) in favor of immune system exhaustion. The interactions of TAMs with TME can affect the function of cytotoxic CD8+ T lymphocytes (CTLs) and natural killer (NK) cells. Furthermore, TAMs can induce cancer cell proliferation by releasing some growth factors, such as transforming growth factor (TGF)-β. TAMs have several positive cross-talks with other immune suppressive cells such as regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), cancer-associated fibroblasts (CAFs), and cancer cells, leading to the release of growth factors, the prolif-eration of cancer cells and tumor growth. These interactions also can induce invasion and migration of cancer cells, angiogenesis, and metastasis. The inhibition of TAMs is an intriguing strategy for overcoming tumor resistance and suppression of cancer cells. Some natural-derived agents such as melatonin, curcumin, resveratrol, apigenin, and other flavonoids have shown the ability to modulate TME, including TAMs. These adjuvants may be able to boost antitumor immunity through the modulation of TAMs. This review explains the modulatory effects of some well-known naturally derived agents on the activity of TAMs. The modulation of TAMs by these agents may be useful in suppressing tumor growth and invasion.
Overexpression of mTOR in Leukocytes from ALS8 Patients
Authors: Gomes Nathália Augusta , das Chagas Lima e Silva Francisco , de Oliveira Volpe Caroline Maria , Villar-Delfino Pedro Henrique , de Sousa Camila Ferreira , Rocha-Silva Fabiana , Nogueira-Machado José Augusto
Published: February 2023

The mutated VAPBP56S (vesicle B associated membrane protein – P56S) protein has been described in a Brazilian family and classified as Amyotrophic Lateral Sclerosis type 8 (ALS8). We aimed to study altered biochemical and immunological parameters in cells from ALS8 patients to identify possible biomarkers or therapeutic targets. Wild-type VAPB, VAPBP56S, mTOR, pro-inflammatory cytokines, and oxidant/reducing ELISA, fluorimetry, and spectrophotometry measured balance levels in serum, leucocytes, and cellular lysate from ALS8 patients and Health Controls. Our results showed similar levels of mutant and wild-type VAPB in serum and intracellular lysate (p >0.05) when ALS8 patients and Controls were compared. IL-1β, IL-6, and IL-18 levels in patients and Controls showed no difference, suggesting an absence of peripheral inflammation (p > 0.05). Oxidative metabolic response, assessed by mitochondrial ROS production, and reductive response by MTT reduction, were higher in the ALS8 group compared to Controls (p < 0.05), although not characterizing typical oxidative stress in ALS8 patients. Total mTOR levels (phosphorylated or non-phosphorylated) of ALS8 patients were significantly lower in serum and higher in intracellular lysate than the mean equivalents in Controls (p < 0.05). A similar result was observed when we quantified the phosphorylated protein (p < 0.05). We demonstrate the possibility of using these biochemical and immunological parameters as potential therapeutic targets or biomarkers. Furthermore, by hypothesis,we suggest a hormetic response in which both VAPB forms could coexist in different proportions throughout life. The mutated VAPBP56S production would increase with aging and predominate over the wild-type VAPB levels, determining the onset of symptoms and aggravating the disease.
Significance of Beta-Blocker in Patients with Hypertensive Left Ventricular
Hypertrophy and Myocardial Ischemia
Authors: Koracevic Goran , Mićić Slađana , Stojanovic Milovan , Bozinovic Nenad , Simic Dragan , Lović Dragan , Krstic Nebojsa , Tomašević Ružica Janković
Published: February 2023

Background:

Arterial Hypertension (HTN) is a key risk factor for left ventricular hypertrophy
(LVH) and a cause of ischemic heart disease (IHD). The association between myocardial ischemia
and HTN LVH is strong because myocardial ischemia can occur in HTN LVH even in the absence of
significant stenoses of epicardial coronary arteries.

Objective:

To analyze pathophysiological characteristics/co-morbidities precipitating myocardial ischemia
in patients with HTN LVH and provide a rationale for recommending beta-blockers (BBs) to
prevent/treat ischemia in LVH.

Methods:

We searched PubMed, SCOPUS, PubMed, Elsevier, Springer Verlag, and Google Scholar for
review articles and guidelines on hypertension from 01/01/2000 until 01/05/2022. The search was limited
to publications written in English.

Results:

HTN LVH worsens ischemia in coronary artery disease (CAD) patients. Even without obstructive
CAD, several pathophysiological mechanisms in HTN LVH can lead to myocardial ischemia. In the
same guidelines that recommend BBs for patients with HTN and CAD, we could not find a single recommendation
for BBs in patients with HTN LVH but without proven CAD. There are several reasons
for the proposal of using some BBs to control ischemia in patients with HTN and LVH (even in the
absence of obstructive CAD).

Conclusion:

Some BBs ought to be considered to prevent/treat ischemia in patients with HTN LVH
(even in the absence of obstructive CAD). Furthermore, LVH and ischemic events are important causes
of ventricular tachycardia, ventricular fibrillation, and sudden cardiac death; these events are another
reason for recommending certain BBs for HTN LVH.
Natural Metabolite Ursolic Acid as an Inhibitor of Dormancy Regulator
DosR of Mycobacterium tuberculosis: Evidence from Molecular Docking,
Molecular Dynamics Simulation and Free Energy Analysis
Authors: Jee Babban , Sharma Prem Prakash , Goel Vijay Kumar , Kumar Sanjay , Singh Yogesh , Rathi Brijesh
Published: February 2023

Background:

DosR is a transcriptional regulator of Mycobacterium tuberculosis
(MTB), governing the expression of a set of nearly 50 genes that is often referred to as ‘dormancy
regulon’. The inhibition of DosR expression by an appropriate inhibitor may be a crucial step
against MTB.

Objective:

We targeted the DosR with natural metabolites, ursolic acid (UA) and carvacrol (CV),
using in silico approaches.

Methods:

The molecular docking, molecular dynamics (MD) simulation for 200 ns, calculation of
binding energies by MM-GBSA method, and ADMET calculation were performed to evaluate the
inhibitory potential of natural metabolites ursolic acid (UA) and carvacrol (CV) against DosR of
MTB.

Results:

Our study demonstrated that UA displayed significant compatibility with DosR during
the 200 ns timeframe of MD simulation. The thermodynamic binding energies by MM-GBSA also
suggested UA conformational stability within the binding pocket. The SwissADME, pkCSM, and
OSIRIS DataWarrior showed a drug-likeness profile of UA, where Lipinski profile was satisfied
with one violation (MogP > 4.15) with no toxicities, no mutagenicity, no reproductive effect, and
no irritant nature.

Conclusion:

The present study suggests that UA has the potency to inhibit the DosR expression
and warrants further investigation on harnessing its clinical potential.
Firm characteristic determinants of Vietnamese textile and garment enterprise participation in production networks
Authors: Trang Tran Thi Thu
Published: February 2023

This paper provides an empirical analysis of Vietnamese textile and garment enterprise participation in global production networks. Based on the overview of Vietnamese textile and garment industry and general information of Vietnamese textile and garment enterprises, it proposed a model and implemented an empirical investigation to identify firm characteristic determinants of Vietnamese textile and garment enterprise participation in production networks. It is the results of combination between some firm characteristic determinants of previous studies and specific features of Vietnamese textile and garment firms. The results suggest that firm size, productivity, foreign ownership, and human capital are the important firm characteristics that determine Vietnamese textile and garment enterprise participation in production networks.
Bonding experiences in times of pandemic
Authors: Loor-Macías Gabriela Jamileth , Briones-Mendoza Stefany Liceth , Vanga-Arvelo María Giuseppina , Macías-Ramos Jorge Líder , Piñero-Martín María Lourdes
Published: February 2023

The university bonding is very important within the integration of education and society, since it allows interaction between science and the common citizen, in addition to training future professionals with civic awareness, entering them into the social experience as workers. On the other hand, the role of virtual tutorials has come to occupy an important role within the modalities of education and an indispensable tool that allows knowledge to be built through participant leader interaction with the support of information technologies. The objective of this research is to identify the incidence of virtual math tutorials on the calcifications average of public education students in high school. One of the consequences of the COVID-19 pandemic was the fact that not all students had the tools to access their virtual classes, and those who did have access were not adapted to this modality; this led to the creation of knowledge gaps, especially in practical subjects such as mathematics. The results indicate that there was a positive impact on the grade point averages showing an increase in them, so it is concluded that it is very important to identify those subjects that merit accompaniment, and through the implementation of virtual tutors, guide students in the process teaching and learning, especially in practical subjects to improve school performance.
Desarrollo de un concentrador centrífugo neumático para el procesamiento en seco de partículas ultrafinas de minerales auríferos: diseño del prototipo
Authors: Mamani-Quispe Jhon Marcelo , Calisaya-Mamani Federico Eleodoro , Taco-Cervantes Homar Henrry , Ascuña-Rivera Víctor Benigno , Juárez-Pinto Diego Edgardo , Guzmán-Jacobo Yvan César , Mamani-Añamuro Mireya Mariela
Published: February 2023

El objetivo del presente trabajo es el diseño de un prototipo de concentrador centrifugo neumático que permita a la minería de pequeña escala que se desarrolla en lugares desérticos y aislados, procesar in situ, de manera limpia, sin uso de agua y reactivos químicos, minerales auríferos ultrafinos. Se aplicó un modelo matemático basado en el análisis físico-fenomenológico del mecanismo de separación de sedimentación diferencial en una película de fluido de flujo laminar, para determinar la trayectoria de las partículas en el interior del tazón del concentrador centrifugo en función de las variables de geometría del tazón, variables de operación y características físicas de la partícula y fluido. Las simulaciones realizadas mostraron un efecto notable del uso de aire en vez de agua sobre la trayectoria de las partículas dentro de la película de fluido. Los resultados también mostraron que la capacidad del concentrador para la separación de partículas por diferencia de densidades más que por diferencia de tamaños, se favoreció al aplicar bajas velocidades de rotación, altos caudales de alimentación de aire y para tamaños de partícula en el rango ultrafino (< 40 μm). El prototipo construido permitirá realizar pruebas experimentales a nivel de laboratorio que complementen la compresión del proceso y afinar el diseño del concentrador.
İLLERDE GÖREVLİ MAARİF MÜFETTİŞLERİNİN İNCELEME-SORUŞTURMA GÖREVLERİ SIRASINDA KARŞILAŞTIKLARI SORUNLAR VE ÇÖZÜM ÖNERİLERİ
Authors: Kazak Ender , Öztürk Nevzat
Published: February 2023

Bu çalışmada, illerde görevli maarif müfettişlerinin inceleme ve soruşturma sürecinde karşılaştıkları sorunlar ve bu sorunlara yönelik çözüm önerileri araştırılmıştır. Araştırma, maarif müfettişlerinin görüşlerinin yüz yüze görüşme tekniği aracılığı ile ele alındığı nitel bir araştırma olup, betimsel durum deseninde tasarlanmıştır. Düzce, Bolu ve Sakarya İl Milli Eğitim Müdürlükleri bünyesinde görev yapan; maksimum çeşitlilik örneklem yöntemiyle belirlenen 19 maarif müfettişi ile görüşmeler gerçekleştirilmiştir. Elde edilen veriler içerik analizi yöntemi kullanılarak incelenmiştir. Araştırma sonunda, inceleme ve soruşturma onaylarının açık ve net olmaması, muğlak ifadelerin yer alması, somut bilgi-belgeye dayanmayan konuların inceleme-soruşturmaya konu edilmesi, istenilen bilgi-belgelerin zamanında verilmemesi maarif müfettişlerinin dile getirdiği başlıca sorunlar olarak tespit edilmiştir. Müfettişlerin iş yoğunluğu, görev tanımında olmayan görevlerin müfettişlere yaptırılması, yasal boşluk, ikili müfettiş sistemi, suç olan fiillerin tam karşılığının yasalarda yer almaması ve özlük ve mali hakların kötü olması, getirilen tekliflerin disiplin amirince uygulanmaması ve sendikal baskılar diğer sorunlar olarak tespit edilmiştir. Araştırma sonunda sorunların çözümüne yönelik öneriler geliştirilmiştir.
AN EXPERIMENTAL STUDY OF THE EFFECT OF VARIATION OF IMPACT LEVELS ON WORKING EFFICIENCY OF ARCHIMEDES SCREW TURBINE ON MICRO-HYDRO POWER PLANT
Authors: Nugraha Andy , Silalahi Dani Surya Hamonangan , Ansyah Pathur Razi , Ramadhan Muhammad Nizar , Amrullah Apip , Cahyono Gunawan Rudi
Published: February 2023

Micro-hydro power plants take advantage of the energy potential of low-head airflow. with the development of technology that can support it, namely the Archimedes screw turbine as the driving force. Various parameters must be considered to determine the performance of micro hydro power plants with Archimedes screw turbines. A design is carried out with a discharge parameter flow rate of 2 l/s, a turbine slope of 300, and an immersion level variation of 0.3, 0.5, and 0.7, where the final result shows the value of torque, hydraulic power, mechanical power, generator, and efficiency, which decreases with the level of water immersion in the last blade.
THE EFFECT OF ELECTRODE COATING FROM BISPHENOL-A-POLYCARBONATE CD-R WASTE FOR HYDROGEN PRODUCTION
Authors: Sulaiman Abdul Mudjib , Mas'ud Sifa'ul , Daroini Ahmad Najih , Purnami Purnami
Published: February 2023

Water electrolysis is a method that utilizes direct electric current to decompose water into O2 and H2. The productivity of hydrogen produced in the electrolysis of water is low. One of the main reasons for the low electrolysis efficiency of water is the resistance of the electrode material. The electrode that is often used in the electrolysis of water is a graphite electrode. The coating on graphite electrodes can be a solution to minimize material degradation at the electrodes. With the condition that the coating material is able to slow down the damage to graphite electrodes and is a good electrical conductor. In this study, we used polycarbonate material as a material for coating the electrodes. The polycarbonate material that will be used is obtained from electrical waste, namely CD-R. The polycarbonate was separated mechanically and then ground to a powder with a size of 400 m. Polycarbonate powder will be coated on the cathode surface by the thermal coating method. Polycarbonate contains Bisphenol A compound which has an aromatic ring. The presence of a magnetic field caused by the delocalization of electrons in aromatic compounds will affect the hydrogen bonding in water. The positively charged surface charge of Bisphenol-A-Polycarbonate is able to reduce the acidity of the solution and accelerate the decomposition reactions of H2 and O2 by the water electrolysis method. Bisphenol-A-Polycarbonate coating is a good inhibitor for graphite electrodes. Coated graphite electrodes have a lower corrosion rate than pure or uncoated graphite electrodes. The layer inhibits the degradation of the material caused by electrochemical events during the water electrolysis process. Bisphenol-A-Polycarbonate (BPA) layer, which acts as an inhibitor and a catalyst simultaneously during the water electrolysis reaction, causes hydrogen production to increase.
EFFECT OF TRACE METAL FECL3 ON BIOGAS PRODUCTION IN INDUSTRIAL WASTEWATER TREATMENT WITH HIGH ORGANIC LOAD
Authors: Yanqoritha Nyimas , Kuswandi Kuswandi
Published: February 2023

Wastewater from the food industry that contains a high organic load, such as wastewater from the tofu manufacturing process, requires an appropriate and efficient treatment system to reduce pollutants before being discharged into water bodies. The most suitable treatment for high organic loads is the anaerobic treatment system. The anaerobic treatment process is a system of suspended media, attached media, or the combination thereof as a hybrid. This study uses a Hybrid Upflow Anaerobic Sludge Blanket (HUASB) reactor with the consideration that this reactor has advantages in maintaining high concentrations of biomass, high operating load rates, good decomposition capabilities, and good solid-liquid separation due to suitable granulation. The purpose of this study was to determine the effect of the addition of the trace metal FeCl3 on biogas production and the ability to remove pollutants in the tofu industrial process wastewater treatment in the HUASB reactor. The operation of the reactor uses variations in the concentration of tofu industrial waste water (75 and 100%) and trace metal concentrations (0.3–0.6 mg/L). The optimum biogas production was obtained with 8190 mL at a concentration of 75% tofu industrial waste water, a trace metal concentration of 0.6 mg/L FeCl3, and removal of COD and TSS of 94.09% and 94.2%, respectively. The role of the trace metal FeCl3in the anaerobic process shows that it is a source of nutrition for increasing the growth of microorganisms in anaerobic systems so that biogas production and pollutant removal are increased.
EFFECT OF VOLTAGE ON THE THICKNESS OF OXIDE LAYER AT ALUMINUM ALLOYS FOR STRUCTURAL BONDING USING PHOSPHORIC SULFURIC ACID ANODIZING (PSA) PROCESS
Authors: Chamidy Harita N , Ngatin Agustinus , Rosyadi Anisa Fitriani , Julviana Arisya , Noviyani Noviyani
Published: February 2023

The aerospace industry mostly uses the aluminum alloys 2xxx and 7xxx series for their fuselage construction, and some of them are assembled using structural bonding because it is strong, easy during the fabrication process, resistant to corrosion, and non-toxic. The anodization process is a proven surface treatment method for structural bonding. Phosphoric Sulfuric Acid Anodizing (PSA) is an eco-friendly alternative as a chromate-free solvent technology for the anodizing process that is applied for structural bonding. The thickness of the oxide layer caused by the voltage given in this process was evaluated in terms of corrosion resistance using the oxide layer's thickness as the main factor. The PSA process of AA2024 T3 clad was carried out at a constant concentration of 125 g/L of phosphoric acid, 80 g/L of sulfuric acid, 27 A, and a temperature of 26 to 28 OC for 23 minutes with various voltages. The voltage was varied at 16, 18, and 20 VDC. The optimum condition for the voltage applied was 18 VDC, which resulted in an oxide layer thickness of 2.76 µm.
Study Efektivitas Ekstrak Kental Kulit Buah Jeruk Purut Terstandar (Citrus hystrix) Sebagai Antioksidan dan Antijerawat
Authors:   Universitas Katolik Widya Mandala Surabaya, Anabella Jessica Maria , Lanawati Darsono Farida ,   Universitas Katolik Widya Mandala Surabaya, Soegianto Lisa ,   Universitas Katolik Widya Mandala Surabaya
Published: February 2023

Salah satu gangguan di permukaan kulit wajah yaitu jerawat yang disebabkan oleh Propionibacterium acnes. Perlakuan jerawat bisa secara oral atau topikal yang umumnya mengandung antibiotika yang lebih efektif mengatasi jerawat, sedangkan kelemahannya mudah terjadi resistensi bakteri terhadap antibiotik. Salah satunya yang potensial dikembangkan sebagai antijerawat dan anitoksidan yaitu limbah dari kulit buah jeruk purut (Citrus hystrix) memiliki kandungan sebagai antibakteri adalah alkaloid, flavonoid (naringenin dan hesperidin), tanin serta senyawa fenolik memiliki aktivitas antioksidan juga sebagai analgesik dan anti inflamasi. Metode ekstraksi secara maserasi dengan pelarut penyari 95% dengan bentuk ekstrak kental terstandar. Konsentrasi ekstrak kental jeruk purut yang digunakan dalam penelitian ini antara 10% - 20%. Dalam rangka penjaminan mutu ekstrak maka dilakukan proses standarisasi secara spesifik dan non spesifik selanjutnya dilakukan uji efektivitas yang terdiri dari aktivitas antioksidan dengan parameter IC50 menggunakan metode DPPH sedangkan antibakteri dilakukan dengan menggunakan parameter Daerah Hambat Pertumbuhan – DHP secara difusi. Tujuan dari penelitian ini untuk mengetahui pengaruh peningkatan konsentrasi sediaan gel ekstrak kental jeruk purut (10%, 15%, dan 20%) terhadap efektivitasnya serta korelasi antara peningkatan aktivitas antioksidannya dengan antijerawatnya (antibakterinya). Berdasarkan hasil percobaan ekstrak kulit buah jeruk purut terbukti memiliki daya antioksidan, dimana dengan peningkatan konsentrasi diikuti dengan penurunan nilai IC50 yaitu 2,49 mg/mL. Nilai DHP ekstrak kulit buah jeruk purut untuk masing-masing konsentrasi 10%, 15% dan 20% berurutan sebesar 15,58 ± 0,287 mm, 17,45 ± 0,319 mm, 18,27 ± 0,306 mm, dimana semakin meningkat konsentrasi ekstrak maka efek sebagai antijerawat juga meningkat. Berdasarkan hasil penelitian tersebut, maka disimpulkan ekstrak kulit jeruk purut berpotensi sebagai antioksidan dan antijerawat.
The use of video conferencing in pre-trial proceedings as a security measure for a participant in an investigative action
Authors:   Alexander Yu. Epikhin  Kazan Federal University, Epikhin Alexander Yu. , Mishin Andrey V. ,   Andrey V. Mishin  Kazan Federal University
Published: February 2023

The article discusses the main aspects of the use of video conferencing during interrogation, confrontation and identification during the preliminary investigation. The authors identified criminal procedural and forensic features of these investigative actions using video conferencing and presented reasonable recommendations for the effective implementation of evidence-based activities. Special attention is paid to the organization and tactics of investigative actions using VKS with the participation of persons in respect of whom security measures are applied. The proposal to improve the tactical provision of interrogation and identification of the protected person in conditions that exclude his visual observation and guarantee the anonymity of his identity is justified. In the course of the study, the method of generalization and comparative analysis of theoretical provisions on the topic under study, as well as special research methods (systemic, comparative-legal, regulatory-logical, etc.) were used as the main method for solving the problem under consideration. Results: the main tactical and procedural features were determined, which, according to the authors, it is advisable to apply during interrogation, confrontation and identification by using video conferencing in pre-trial proceedings. The practical significance of the implementation of new means of increasing the effectiveness of the evidentiary activities of the investigator in criminal proceedings is approved. Attention is focused on tactical recommendations aimed at using the VKS during interrogation and identification with the participation of the protected person.
Legal registration of serfdom in Russia
Authors:   Angela K. Khalifaeva Dagestan State University, Khalifaeva Angela K. , Amirkhanova Madina Kh. ,   Dagestan State University
Published: February 2023

The origin and development of serfdom in is one of the most complex processes. Unlike European states, in Russia it had some features: a distinctively late period of occurrence, the connection of the emergence process with the evolution of landed property. Serfdom, which formed the basis of the Russian order, inevitably had to receive its more or less clearly developed legal form. Serfdom was formed by virtue of the actual state of affairs, determined by the attachment of the peasant to the land and his subordinate position. In order to sufficiently reveal the issue of the legal registration of serfdom in Russia, it is necessary to consider its development in stages, based on legislative acts, which most fully and objectively affected the enslavement of the peasant population and changed the legal status of residents. The article examines the history of the emergence of serfdom from the moment of its inception to its legal consolidation; changes in the state and the impact of the legal consolidation of serfdom on the development of the Russian state, the essence of serfdom and what stages it went through from its inception to its abolition, inclusive. Also, the article describes the views of Russian and Soviet historians on the circumstances and causes of the emergence of serfdom. Various scientific and historical approaches to the problem of studying serfdom in Russia are analyzed, the consequences of serfdom for Russia and the Russian people are described. Moving on to the stage of emancipation of the peasants, historians are unanimous that serfdom had a negative impact on all aspects of society, but for Soviet historians, serfdom became one of the reasons for the "economic and cultural backwardness of Russia", and for "Western historians –a consequence of backwardness".
The Glass Figure
Authors: Camacho Sandra
Published: February 2023

In this article, I propose to examine how prosopopoeia might be identified in some of André Kertész’s final photographic works, not only in the recourse of a glass figurine, that stood-in for his late-wife, Elizabeth, but also through the analysis of his choice of medium, the Polaroid: an image that holds a distinct material existence, small enough to share, and captivating in its instant development before one’s eyes. Additionally, I will consider the association of prosopopoeia and death, as a literary figure that gives voice to those that have lost it, but also in the very mourning process for Kertész.
Intrinsic Lexical Intentionality and the Mathematics of Homomorphism
Authors: Moisl Hermann
Published: February 2023

Moisl [1, 2] proposed a model of how the brain implements intrinsic intentionality with respect to lexical and sentence meaning, where 'intrinsic' is understood as 'independent of interpretation by observers external to the cognitive agent'. The discussion in both was mainly philosophical and qualitative; the present paper gives a mathematical account of the distance structure preservation that underlies the proposed mechanism of intrinsic intentionality. The three-layer autoassociative multilayer perceptron (aMLP) architecture with nonlinear hidden and linear output layers is the component in the model which generates representations homomorphic with the environment. The discussion first cites existing work which identifies the aMLP as an implementation architecture for principal component analysis (PCA), and then goes on to argue that the homomorphism characteristic of linear functions like PCA extends to aMLPs with nonlinear activation functions in the hidden layer. The discussion is in two main parts: the first part outlines the model, and the second presents the mathematical account.
Effects of Multimodal Listening Instruction on Listening Performance of Rural Middle School Students from East China
Authors: Fan Kaifang , Qi Yue
Published: February 2023

To overcome the key factors affecting the instruction of English listening is of vital importance for English teaching in rural middle schools. In this study, we conduct a quasi-experiment following the multimodal instruction model to explore the effectiveness of the multimodal instruction model. Firstly, the research adopts a mixed research method to extract the key factors that have influence on the English listening level of rural middle school students. Then, taking into consideration the influencing factors, a multimodal listening instruction model is designed for instruction experiments. The study, then, collects data via questionnaire survey and conducts statistic analysis to analyze the results of listening tests after instruction experiments. The results show that the multimodal listening instruction model can effectively stimulate students to improve their English listening ability, and its effectiveness on detailed information comprehension is greater than that on inference question. The results of the study can guide rural middle school English teachers to give priority to the use of multimodal listening instruction mode in listening details, and help students effectively improve listening effects.
Adapting Kwl Strategy for Teaching Science Practicals to Children with Special Needs for Effectives Learning
Authors: Agbo Felicia O. , Taukek Emmanuel , Ejigbo Joy O. , M. Sado Mohammed , Wadatau Sani
Published: February 2023

The learning of science is imperative for development in every society, and so it should not be limited to some persons. Therefore, these study sets out to use KWL strategy to adapt science teaching to the children with special needs for effective learning.The research design used in this study was the quazi experimental design specifically the pretest-posttest method. Three research questions guided the study. The sample of the study was made up of eight junior secondary one students from one public school in Lamingo, Jos plateau Nigeria. Intact class was used because there was no randomization. Base line data was collected from the class teacher on the students previous performance on the topic Classification of food. The researcher later taught same topic using KWL strategy for three weeks after which a test is given to collect data in form of scores. The data was analysed using percentage.The findings showed that KWL engaged students in the topic taught and also activated prior knowledge. KWL also enhanced good performance, thinking skill and promote curiosity.The researchers recommended that: teachers should ensure that appropriate activities be planned to take care of student needs; Government to ensure that all children have an equal right to education of any type.