bluuebunny/crossref_metadata_2025 huggingface dataset:
Современное материнство в сельской местности Азербайджана: карьера, семья и ценности воспитания
Authors: Алмазова Ольга В. , Азимзаде Айдан А. , Гаврилова Маргарита В. , Бабаев Мурад А.
Published: February 2023

Введение. Характерными чертами современного материнства являются желание женщин совмещать профессиональную карьеру с воспитанием детей, стремление форсировать развитие ребенка при осведомленности о нормативных этапах развития. Эти черты по-разному проявляются в разных социокультурных условиях. Была поставлена задача проследить, как современные тенденции отражаются на представлениях о воспитании детей у мам, проживающих в сельской местности Азербайджана, что является неизученной проблематикой. Методы. Выборка – 411 мам дошкольников, проживающих в сельской местности Азербайджана. Диагностический материал: опросник родительских убеждений о воспитании (E. Hembacher, M. C. Frank) и авторская анкета, направленная на получение дополнительных сведений об отношении к материнству и ожидания от ребенка. Результаты. Установлено, что азербайджанские женщины в большей степени ориентированы на то, чтобы быть женами и мамами, а не заниматься профессиональной деятельностью. В вопросах воспитания детей мамы доверяют старшим членам семьи и специалистам и не доверяют интернет-ресурсам. Наиболее предпочитаемыми качествами для своих детей называют патриотизм, уважение старших и стремление повышать образование и культурный уровень. Разделяемыми большинством азербайджанских мам, проживающих в сельской местности, утверждениями в вопросах воспитания детей являются следующие: «важно научить ребенка слушаться и уважать старших»; «важно дать детям возможность исследовать мир»; «надо читать ребенку и говорить с ним, даже пока он сам не может говорить»; «родители должны утешать детей, когда они напуганы или расстроены» и «родители должны знать, что любит и что не любит их ребенок» и др. Обсуждение результатов. Азербайджанские мамы детей 3–7 лет, проживающие в сельской местности, не стремятся форсировать развитие ребенка, нацелены на реализацию себя в семейных ролях и имеют основные, но не всегда полные, знания об особенностях развития детей дошкольного возраста.
Осознанное восприятие: дискретность vs непрерывность
Authors: Костина Дарья И. , Филиппова Маргарита Г. , Аллахвердов Михаил В. , Аллахвердов Виктор М.
Published: February 2023

Аннотация: Введение. Является ли восприятие дискретным или непрерывным? Этот вопрос имеет давнюю историю, но в свете полученных в последние годы экспериментальных данных снова обретает актуальность. Имеющиеся модели опираются на разное понимание дискретности, и в них выделяются разные единицы дискретного восприятия. Теоретическое обоснование. В статье рассматривается развитие дискретных моделей восприятия и разбираются различные теоретические обоснования дискретности. Результаты и их обсуждение. Приводится обзор экспериментальных исследований, поддерживающих дискретные модели, обсуждаются основные направления их критики. Результаты новых исследований поддерживают идею о том, что дискретно именно осознаваемое восприятие, тогда как неосознаваемая обработка информации может быть непрерывной или осуществляться с бо́льшим временны́м разрешением. Сравниваются два популярных современных подхода к дискретному восприятию. В рамках одного из них предполагается, что дискретная единица восприятия относительно невелика и связана с временны́м разрешением, при этом она не является универсальной – дискретизация может осуществляться с разной частотой, например, для разных модальностей. В рамках второго подхода дискретизация связывается с необходимостью вычисления наилучшей осмысленной интерпретации поступающих данных. Дискретная единица в этом подходе (временно́е окно неосознаваемой обработки) является универсальной, но ее длительность не фиксирована и зависит от характера поступающих данных. Также предлагается альтернативный подход, опирающийся на положения концепции негативного выбора В. М. Аллахвердова, из которой также следует существование окна неосознаваемой обработки, длительность которого не является постоянной. Новизна данного подхода в том, что длительность окна связывается со сложностью операций контроля, задачей которого является отбор информации для поступления в сознание. Обсуждается возможность использования этого подхода для объяснения временно́й динамики эффектов прайминга и мигания внимания, за непостоянством временны́х границ которой мы видим проявление общей логики дискретизации.
Структурно-функциональная организация жизненной успешности как метаресурса личности современного преподавателя высшей школы
Authors: Семенова Наталья А.
Published: February 2023

Введение. Обоснована актуальность исследования в связи с изменениями в мире и, в том числе, процессами в системе отечественного высшего образования, когда происходят преобразования с учетом интересов национальной экономики. Представлен новый взгляд на проблему исследования личностных ресурсов преподавателя высшей школы, где особое внимание уделено вопросу поиска функциональных образований, позволяющих наиболее эффективно осуществлять профессиональную деятельность и сохранять функционирование собственной личности на продуктивном уровне. Впервые в рамках разрабатываемой метаресурсной концепции предложено понимание жизненной успешности. Поставлена проблема необходимости исследования структурно-функциональной организации жизненной успешности преподавателя высшей школы с целью выявления и изучения ее особенностей. Методы. В исследовании приняли участие 164 преподавателя образовательных организаций высшего образования из различных регионов России от 27 до 77 лет. Исследование проведено с использованием самооценочной авторской методики «Жизненная успешность». Опрос проводился посредством размещения в Google Forms. Результаты. Получены следующие результаты: наиболее выражены праксические, бытийные переживания и субъективная оценка своей жизненной успешности; в меньшей степени выражены интегральные качества успешности и нравственные переживания; среднее значение субъективной оценки жизненной успешности составляет 7,23 по десятибалльной шкале; на первое место по значимости для успешной жизни выходят ценности семьи и здоровья; положительные значимые взаимосвязи обнаружены между рефлексивными механизмами и интегральными качествами жизненной успешности. Обсуждение результатов. Результаты позволили сделать выводы о наличии сильных сторон и проблем метаресурса жизненной успешности респондентов. Сильные стороны включают в себя: большое количество взаимосвязей между компонентами жизненной успешности; выраженность праксических переживаний, продуктивной жизненной диспозиции, рефлексивно-онтологического механизма жизненной успешности; приближенность реальной ценностной иерархии к идеалу успешности; функциональную значимость инструментальных качеств и направленности на успех. Выявленные проблемы могут быть «точками роста» для наиболее продуктивного функционирования метаресурса жизненной успешности.
A Review and Meta-analysis on Trastuzumab Resistance in Patients with
HER2+ Breast Cancer
Authors: Júnior Alexandre Holzbach , Cima Bernardo Perin , Staffen Mari Dalva , Lindenau Juliana Dal-Ri , Netto Muniz Yara Costa
Published: February 2023

Background:

Trastuzumab is a monoclonal antibody that revolutionized the treatment of
HER2+ breast cancer. However, about 30% of patients demonstrate resistance to this drug

Objective:

The purpose of this study is to identify the mechanisms involved in resistance to treatment
with trastuzumab in women undergoing HER2+ breast cancer treatment.

Methods:

A wide review and meta-analysis were performed in the PubMed and Scielo databases up to
January 2022. All articles that analyzed the efficacy of the drug in HER2+ human patients treated with
trastuzumab were selected, except reviews, meta-analyses, and reports. Egger’s test was applied to
verify publication bias. Forest plot and PRISMA flowchart were employed.

Results:

60 articles were selected for the review and 15 included in the meta-analysis. A total of 102 resistance
mechanisms were identified, 73 of which are different from each other. The mechanisms have been
classified into 5 different categories. The main resistance mechanisms found are in the PI3K/Akt/mTOR
pathway or related to low HER2, often resulting from failure to assess HER2 status. Both groups presented
statistical significance. The two groups were not significantly different from each other.

Conclusion:

Drug resistance is the main challenge of trastuzumab-based treatment. To overcome this
challenge, it is important to continue efforts to understand the mechanisms of cancer drug resistance,
identify therapies that can treat refractory cancer to current therapies, and possibly create a panel of
genes that predict resistance, avoiding symptomatic and economic costs. The main limitation of this
study was the selection and population bias.

PROSPERO Registration Number:

This study is registered in PROSPERO (CRD42020169304).
Research Advances of Clinical Application of Oncolytic Viruses in Treatment
of Gynecologic Cancers
Authors: Deng Mingjing , Wang Qi
Published: February 2023

Oncolytic viruses (OVs) have become one of the main strategies of cancer biotherapy. They
are genetically engineered or naturally occurring viruses that selectively replicate and kill tumor cells
without harming normal tissues. Gynecologic cancers have become a major health problem for women.
OVs therapy plays an increasingly important role in the treatment of gynecological tumors with promising
clinical effects. A variety of OVs is used in the treatment of gynecological tumors, either as single
oncolytic virus therapy or in combination with other therapies. Some oncolytic virus therapies have
entered early clinical trials and have shown favorable safety, clinical activity, and immune activation.
The present study summarized the anti-tumor mechanism of OVs and their modifications. The study
reviewed the latest clinical progress on the application of the OVs in the treatment of gynecologic cancers.
The unique challenges in the development of the viruses as a novel drug for the treatment of gynecologic
oncology were also discussed and their future prospects were elucidated.
A Framework of Nutrient Analyser Model for Comparing Food Nutrients
Authors: Ng Set Foong , Tukiman Norbaiti , Ismail Azianti , Khalid Ahmad Khudzairi , Yunos Nurhazirah Mohamad , Norizan Nurul Aznyda
Published: February 2023

Background:

Consumers’ lack of nutritional awareness causes them to have little interest
in reading and analysing nutritional information on food labels. Rigorous and scientific
comparisons of the nutrient contents of commercial buns are rarely conducted in Malaysia.

Objective:

The first objective of this study is to classify nutrient contents in commercial buns into
beneficial and non-beneficial nutrients. The second objective is to develop a nutrient analyser
model framework to compare the nutrient contents for different types of commercial buns.

Methods:

The nutrient analyser model was developed based on the mathematical theory Technique
for Order of Preference by Similarity to the Ideal Solution (TOPSIS) and Shannon’s Entropy
Model. The framework of the nutrient analyser model using the two theories was developed.
Nutritional data taken from several commercial buns in Malaysia was applied to the model.

Results:

The results show that the model was able to identify the type of bun having the most beneficial
nutrient contents and the least non-beneficial nutrient contents.

Conclusion:

The framework of the nutrient analyser model could serve as a reference for other researchers.
The findings benefit the community and researchers as the results indirectly improve
consumer awareness of food nutrients prioritizing good health.
Glycation-induced Amyloid Formation in Proteins: An Emerging
Perspective to Explore Diabetes Associated Onset of Neurodegenerative
Symptoms
Authors: Prosad Banik Samudra
Published: February 2023

Non-enzymatic protein glycation occurs spontaneously via the formation of sugarprotein
Schiff adducts. The end products of this pathway are terminally misfolded proteins popularly
known as Advanced Glycation End (AGE) Products. Glycated proteins account for a diverse
spectrum of physiological maladies including arteriosclerosis, renal failure, diabetic complications,
obesity, and neurological disorders. AGEs not only jeopardise the functionality of
modified proteins but also induce the formation of Covalent protein cross-links. Glycation has
the potential to induce the unfolding and refolding of globular proteins into cross-β structures
thus resembling many amyloid deposits like amyloid beta, tau protein, and prions. However,
glycation-induced amyloid formation is not a generic property of proteins; instead, it is guided by
the nature and conformation of the protein, the type of glycation agent as well as the solution
conditions governing the glycation reaction. The half-lives of AGE adducts are prolonged by
their impaired proteasomal clearance since glycation modifies the lysine residues and renders
them unavailable for ubiquitination. AGEs are cleared via sequestration with specific cell surface
receptors (RAGE); subsequently, downstream signalling events involving MAPK and NF-κB
result in the activation of inflammatory response or the apoptotic pathway. This perspective article
discusses the current developments in understanding the various facets of glycationassociated
protein aggregation and the corresponding development of amyloid-like entities.
A Cross-Validation of the Revised Moral Virtue Scale for Thai Nursing Students: Confirmatory Factor Analysis and Multiple-Group Approach
Authors: Orathai Pisamai , Chaimo Kesinee , Chuengkriangkrai Benchaporn
Published: February 2023

Background

The preparation of ethics in the nursing profession must be an incubator when becoming a nursing student to raise awareness of the importance and the need for professional development. In evaluating nursing students’ moral behavior, it is essential to have a well-developed instrument that reflects the actual moral behavior of nursing students.

Objectives

To correct the limitations of the preliminary Moral Virtue Scale for Thai Nursing Students by developing and evaluating the construct validity and reliability of the revised scale.

Methods

An extensive literature review and the preliminary scale were used to synthesize and develop the moral virtue definition, domains, items, and hypothesized model. The revised scale was tested on 1,000 nursing students from two nursing education institutes. The sample was split into a calibration sample (n = 489) and a validation sample (n = 511) to examine the construct validity and reliability using confirmatory factor analysis and multiple-group analysis.

Results

Confirmatory factor analysis and a multiple-group approach provided evidence of construct validity and construct reliability. Both calibration and validation groups supported a consistent factor structure. The calibration group satisfied the Cronbach’s alpha coefficients of ten domains from .75 to .87. A full scale was .97. In the validation group, the Cronbach’s coefficient values ranged from .78 to .92, and a full scale was .98.

Conclusion

Providing a valid and reliable instrument in this study may benefit the nurse educators. The revised scale can potentially measure and monitor Thai nursing students' moral behavior.
Evaluation the Factors Influencing Self-leadership in the Saudi’s Healthcare Sector: Systematic Review
Authors: Almeharish Amani , Bugis Bussma Ahmed
Published: February 2023

Background

Self-leadership in the Saudi Arabian healthcare sector is vital due to the ongoing transformation of this industry. However, research on the self-leadership training for the Saudi healthcare workers is presently limited.

Objective

A systematic review of literature is performed, focusing on articles pertaining to self-leadership and the impact of factors influencing self-leadership in the Saudi Arabian health sector.

Methods

PRISMA reporting was used for this systematic review. Data was sourced from various electronic databases, based on predefined selection criteria.

Results

Nine studies met the study inclusion criteria and were reviewed further. Results showed lack of evidence on the leadership training for healthcare workers in the Saudi Arabian healthcare sector. In some studies, self-leadership was associated with emotional intelligence, education, job satisfaction, job engagement, and the internalized moral skills. High levels of self-leadership positively correlated with increased performance of healthcare workers in the Saudi Arabian health sector.

Conclusion

Healthcare workers should have the necessary skills and strategies to develop self-leadership, thus enhancing communication competence and collaboration to achieve high performance in the health sector. Further research is needed in the Saudi Arabian healthcare sector to close the literature gap regarding self-leadership.
Accounting for the Influence of Heat-Moisture Treatment Mode When Designing Concrete Composition
Authors: Dvorkin Leonid , Zhitkovsky Vadim , Makarenko Ruslan
Published: February 2023

The article proposes a method that considers the parameters of heat and moisture treatment of concrete when designing its composition. Based on the analysis of experimental data, formulas are proposed that allow taking into account the type and characteristics of cement, the characteristics of aggregates, the effect of temperature and duration of steaming, and the water-cement ratio. Graphs and nomograms have been obtained, which makes it possible to simplify the calculation procedure according to the proposed method. Typical numerical examples of the application of this technique are given.
Give and Take: Fostering Greater Participant-Centricity In A Digital Decentralized Trial Of Rare Disease Patients (Preprint)
Authors: Framroze Zeenia , Rinaldo Francesca , Lewis Emily , Steels Jean-Christophe , Dickinson Harriet
Published: February 2023

UNSTRUCTURED

The acceleration of decentralized and digital methodologies for study data collection has created an opportunity to employ more participant-centric approaches in clinical research. Many studies now include digital and non-digital outcome measures that capture symptoms, daily functioning and health-related quality of life measures in ways that are meaningful to and interpretable by patients. However, study patients are rarely privy to the benefits and insights that clinical research yields. In particular, there are two barriers to providing patients with the benefits of participating in research: studies that produce data that are inaccessible to participants (“unidirectional” data), and studies that create results that are incomprehensible to participants (“unilingual” data). To be both effective and engaging for the participant, clinical research can no longer be one-sided. Decentralized clinical studies leverage technology to ease the burden of data collection on participants, allowing them to contribute their data remotely without having to travel to specific study sites, which can lead to a more equalizing and empowering approach to patient-centric research. Our experience of these benefits is illustrated by a case study of a direct-to-participant, prospective, observational decentralized study with myasthenia gravis patients (Trial Registration: ClinicalTrials.gov NCT04590716), including an improved overall trial experience; increased adherence levels to study tasks and assessments; and an opportunity for participants to gain a greater understanding of their symptoms, such as recognizing trigger factors for disease exacerbations.
Problems of thoracic trauma: pulmonary contusion
Authors: Nikonov V.V. , Kursov S.V. , Biletskyi O.V. , Feskov O.E. , Skoroplit S.M.
Published: February 2023

The review considers the problem of pulmonary contusion in the intensive care clinic. The frequency of pulmonary contusion in patients with isolated thoracic injuries, polytrauma and its influence on the course of the traumatic disease and the mortality rate are given. The leading pathophysiological mechanisms that take place in pulmonary contusion are discussed. Quantitative evaluation of the severity of thoracic trauma and lung injury are briefly considered. Modern measures of intensive care in patients with pulmonary contusion are highlighted, with an emphasis on the need for respiratory support. The importance of respiratory support for the survival of patients with pulmonary contusion and the auxiliary value of pharmacological methods are emphasized.
Evaluierung des Förderungsprogramms IÖB-Toolbox
Authors:   Joanneum Research GmbH, Streicher Jürgen , Schütz Marlies , Sauer Angelika , Buchinger Eva ,   AIT - Austrian Institute of Technology, Mehnert Wenzel
Published: February 2023

Innovationsfördernde öffentliche Beschaffung (IÖB) ist in Österreich seit 2007 Thema und in der nationalen Agenda der Innovationspolitik strategisch wie inhaltlich gut verankert. Wesentliche Meilensteine der Umsetzung des 2012 beschlossenen Leitkonzepts für eine innovationsfördernde öffentliche Beschaffung der letzten Jahre sind auf organisatorischer Ebene die Etablierung eines IÖB-Service Netzwerkes mit der IÖB-Servicestelle als Knotenpunkt und komplementären IÖB-Kompetenz- und Kontaktstellen. Die gegenständliche Evaluierung baut auf der Zwischenevaluierung des Förderungsprogramm von 2021 auf, in welcher die Genese und die Entwicklung der IÖB-Toolbox in der ersten Programmphase (2019-2020) im Vordergrund stand. Ziel der vorliegenden Untersuchung ist es, die Konzeption und die bisherige Umsetzung des Förderungsprogramms seit dessen Start im Jahr 2019, über die zweite Förderperiode (2021) bis hin zur aktuellen, dritten Förderperiode (2022-2023) gesamthaft zu beleuchten.
La apropiación de la flâneuse en Diane di Prima
Authors: Geerts Zapién Ambar
Published: February 2023

La voz poética de Diane di Prima (1934-2020) se encuentra, al menos en las primeras décadas de su vida, estrechamente relacionada con el entorno urbano. Esta relación refleja la complejidad que implican la subjetividad y la corporalidad femeninas en una urbe donde las esferas de lo público y lo privado se encuentran claramente delimitadas y separadas en términos de clase y de género. El medio urbano, con sus múltiples posibilidades de experiencia humana, brinda a la poeta estadounidense material fundamental para la formación de su voz, pero también para construir y representar la ciudad que habita, y es, en este sentido, una fuente primordial de su identidad como poeta. Al entablar un diálogo con la tradición poética de la metrópolis y con el paradigma literario del flâneur, Di Prima se inserta dentro de esta tradición. Además, también se apropia de y cuestiona varios aspectos de esta tradición, tales como la supuesta masculinidad del flâneur como figura literaria y los mitos del originen masculino de su construcción. El resultado es una intertextualidad que problematiza esta filiación a través de un juego de alteraciones de algunos de sus componentes esenciales, como la mirada, la presencia del cuerpo femenino en el espacio urbano y la validez del acceso a este espacio como flâneuse, conectando su obra temprana con la historia de las representaciones poéticas de la ciudad contemporánea.
Fotografías narrativas: el archivo multimodal en Desierto sonoro de Valeria Luiselli
Authors: Velázquez Soto Armando Octavio
Published: February 2023

Publicada en inglés en 2019, Lost Children Archive fue traducida al español como Desierto sonoro. En esta novela, Valeria Luiselli entreteje la historia del viaje de una familia a través de Estados Unidos con los ecos de los apaches masacrados a lo largo del siglo XIX y las penurias de miles de niños migrantes centroamericanos que intentan llegar al país del “sueño americano”. Con referencias claras a las road trip novels, uno de los elementos más importantes en esta novela es el archivo como tema literario y procedimiento de composición. En consonancia con diversos estudios realizados sobre Desierto sonoro, en este trabajo propongo un acercamiento a la obra a partir del “paradigma del archivo”, del cual forman parte múltiples producciones artísticas contemporáneas, pero centrándome en los elementos visuales que aparecen en el libro: dibujos, mapas y fotografías. Asimismo, para abordar las tensiones significativas producidas entre el texto y las imágenes, recurro a algunas de las propuestas de los estudios multimodales aplicados a la literatura. De esta manera, realizo un breve análisis de la estructura de la obra y posteriormente perfilo algunos de los elementos de las poéticas de archivo, vinculándolas con ciertas propuestas de los estudios multimodales aplicados a la literatura.
El impacto de la violencia en la identidad narrativa: una aproximación desde los estudios del discurso. Caso: Persépolis de Marjane Satrapi
Authors: Pérez-Pérez Jéssica Aidé
Published: February 2023

En esta contribución discuto el tema de la violencia y su impacto en la identidad dentro de la novela gráfica Persépolis (2000-2003). La autora de este discurso autobiográfico multimodal, Marjane Satrapi, narra su experiencia individual sobre la revolución iraní e instauración del régimen islámico de finales de los años setenta. El corpus está compuesto por dos secuencias que he seleccionado de acuerdo con las epifanías de la autora —(1) la muerte de su amiga Neda y (2) su migración forzada a Europa— para demostrar cómo estos momentos de transformación identitaria dentro del discurso se vinculan con las diferentes formas de la violencia. Cada secuencia es analizada desde el método biográfico-narrativo y con herramientas procedentes tanto del análisis del discurso multimodal como de los estudios de la identidad. Parte de los resultados exponen que la narradora utiliza diversos elementos evaluativos, inscritos dentro de los recursos semióticos icónicos y lingüísticos, que permiten evaluar los eventos y las acciones propias y ajenas. Con lo anterior, se evidencia que la violencia subjetiva-sistémica transformó al sujeto de dos maneras: en una mujer valiente y en una mujer desarraigada de su cultura y de sus lazos familiares. En conclusión, el sujeto es trastocado por factores contextuales no sólo históricos, sino políticos, sociales y culturales que lo condicionan al cambio a través del tiempo. La narradora se configura a partir del relato doblemente articulado y en los diferentes modelos de acción que afectan, principalmente, su identidad-ipse.
La construcción de la identidad de un héroe: visiones de la infancia en El árabe del futuro de Riad Sattouf
Authors: Andrade Quintero Laura Catalina
Published: February 2023

Este artículo busca analizar los elementos a través de los cuales se construye la identidad del héroe en la figura del niño en el cómic El árabe del futuro de Riad Sattouf. Al explorar su propia infancia, itinerante y multicultural, Sattouf crea una imagen de su yo niño vista desde diferentes perspectivas. Para empezar, los viajes, que marcarán ese periodo de su vida y el de su familia, constituyen el hilo conductor de una historia atravesada tanto por los designios del padre como por la historia de diferentes países de Oriente Medio desde finales de los años setenta hasta mediados de los años noventa. Sumado a esto, la autoridad y las imposiciones del padre serán determinantes para el personaje de Riad niño, que lo admira y lo venera, pero que a medida que pasa el tiempo y avanza la narración se percata de que la imagen que había construido en torno a él estaba distorsionada o al menos incompleta. De esta manera, Sattouf nos ofrece un relato autobiográfico que a lo largo del cómic se sirve de aspectos como el uso del color para distinguir los espacios geográficos por los que transita y, a la vez, para establecer relaciones de afecto y cercanía con esos lugares que habitó durante su niñez. A lo largo de seis volúmenes, El árabe del futuro enfatiza el valor de la figura del niño como un héroe de lo cotidiano, de curiosidad e imaginación sin límites, de pequeñas hazañas y grandes descubrimientos.
CFD Analysis of Pressure Variation inside Iron-Ore Slurry Pipelines
Authors: Mishra Sai Swapnesh , Sahoo Sibajyoti Danapriya
Published: February 2023

Abstract: Slurries, basically regarded as two – phase (solid – liquid) mixtures of ore and the carrier medium, generally water, are transported through underground pipelines. The rheological properties of the slurry also play an important role in determining the salient parameters of hydraulic transport such as head loss and pressure drop in commercial slurry pipelines. CFD has provided an upper hand in mathematical modelling and flow simulation, as it provides accurate and dependable flow simulation results. This article primarily focuses on determining the pressure drop across the ends of the pipeline, as slurry flows through it, and to establish a graphical depiction of the various simulations made using different set of conditions. The pressure drop for R500 radius of curvature of bends was found to be lying between 4.27% to 6.53%, as the bend angles increased from 3° to 18°, while the same was found to be lying between 3.49% to 6.2% for R2500 radius of curvature of bends. The pressure drop for R500 radius of curvature of bends was found to be lying between 4.91% to 8.3%, as the inlet velocity of slurry increased from 0.5 m/s to 3m/s, while the same was found to be lying between 5.05% to 8.63% for R2500 radius of curvature of bends.
Exploring Tourism Potential for Miao town of Changlang District in Arunachal Pradesh
Authors: Choudhury Abhishek , Das Bijay Kumar , Anshu Snehal
Published: February 2023

Abstract: Hill tourism has always been a part of the attraction because of its scenic beauty, better air quality and a favourable thermal environment. Although the north-eastern part of India has a plethora of tourist attractions, little has been done to explore the natural resources. Patkai,a range in the Himalayas, is home to a vast variety of wildlife and has a unique ecosystem that attracts nature lovers looking for exceptional experiences. In the setting of hill regions nestled in the Himalayas, the religious and socio-cultural components of the tourism resources are of equal importance to the many dazzling natural attractions and aesthetic beauty. Nature related activities and sports have transformed the hill recreation tour into an adventure tour. Mountaineering and adventure tourism alone generate significant revenue from tourism. The unrelenting influx of tourists to these hubs has upset the traditional demand and supply balance due to a lack of forethought. Acute problems with land use, environmental pollution and deterioration, demand on infrastructure, transport, and services. Arunachal Pradesh state lies in Eastern India and has a mountainous terrain with rich flora and fauna. Changlang district lies in south-eastern part of Arunachal Pradesh. A better planning and systematic regulation can improve the tourism and tourism management both.
In-vitro experiment of nitrogen fixing capacity of indigenous and exogeneous Azotobacter sp at Andisol tea planting areaâ€™s
Authors: Pranoto Eko , Setiawati Mieke Rochimi
Published: February 2023

An in-vitro experiment to evaluate total nitrogen content of soil of tea plantation area included with indigenous and exogenous AzotoÂ­bacter sp have been conducted in the Biology and Soil Biotechnology Laboratory, PadjaÂ­djaran University. A completely randomized design with 11 treatments and three repliÂ­cations was used. The treatments were: A (neÂ­gative control); B (positive control); C (A. Kedelai II); D (A. vinelandii); E (A. N.D.9.3); F (A. Padi); G (VI-1); H (II-1); I (V-2); J (I-1); and K (III-2). Size of microbe inoculated popuÂ­lation for each treatment was 1,2 x 1011 CFU/ml. One percent dose was used for steÂ­rilized soil originated from the tea plantation area. After five days of incubation period reÂ­vealed that II-1 Azotobacter sp produced very significantly different in total nitrogen proÂ­duction than the other Azotobacter sp, i.e. 0,8532%. Orthogonal comparisons indicated that indigenous Azotobacter sp had the capacity of nitrogen fixation 7,67% higher than that the capacity of nitrogen fixation of exogenous Azotobacter sp for growth on Andisol soil of tea plantation area with pH of 4,5-5,6. Although, Azotobacter sp is very rarely found in soil with low pH (high acidity), this phenomena indiÂ­cating that an active biofertilizer of indigenous Azotobacter sp is present in tea plantation area.
Synthesis of quinine N-oxide and an NMR tutorial in its structure determination
Authors: Aisyah Aisyah , Tamaela Nila Berghuis , Santoso Joko , Syah Yana Maolana , Mujahidin Didin
Published: February 2023

Cinchona alkaloids are one of abundant natural chiral pool for organocatalysts. The application of an N-oxide group containing molecule in asymmetric reaction is currently wide developed. The structure of quinine consist two amine groups that could be oxidized to the N-oxide groups at N-1â€™ of quinoline and at N-1 of quinuclidine moieties. The oxidation reaction took place selectively at quinuclidine moiety by controlling the concentration of oxidizing agents. In this study we showed that N-1-oxide quinine could be occurred chemoÂ­selectively by using a low concentration of ozone thana palladium catalyzed oxidation. The structure of products N1-oxide quinine was elucidated by spectroscopy data including 1H-NMR, 13C-NMR, 2D-NMR, infra-red and mass spectrometry. The developed method is a chemoselectively and eco-friendly method for synthesis N1-oxide quinine.
An assessment of genetic relationship in tea clones based on important chemical compound and yield potential
Authors: Sriyadi Bambang
Published: February 2023

Assembling of new excellence high yielÂ­ding and good quality tea clones was started from identification accession as gene sources, crossing design of parents, selection mother bushes and propagated vegetatively. Crossing beetwen two parent clones which near or remote genetic relationship in tea will failed. Assessment of genetic relationship clone accession was done using secondary datas from description of first and second tea clone geneÂ­ration which cultivated in Indonesia. Data of yield potentials and main chemical comÂ­pound of quality among others catechine, gallat cateÂ­chine, catechine gallo and cafeine were anaÂ­lysed using biplot and cluster analysis. The results showed that no correllation beetwen main chemical compound of quality and yield potentials. Biplot with two dimensions could be explained 92,5% variation of five characters and showed that yield has the highest and catechine the smallest variances. The first geneÂ­ration of tea clones was separated to second at the 46,79% similarity levels. At the 15,60% similarity levels, there were six clusters. GMB 1, GMB 2, GMB 6, GMB 9, and GMB 10 clones were in one cluster was caused of they had high of yield and catechine. GMB 4 and GMB 5 had similarity on medium yields, GMB 7 and GMB 11 had similarity on medium catechine and the highest yield, and GMB 3 and GMB 8 had similarity on low catechine. PS 1 with the lowest catechine gallo was separated to the others. The sixth cluster were SA 40, Kiara 8, SA 35, RB 3, and Cin 143 were characterized by low catechine and yields.Â
Analisis Pengendalian Biaya Tenaga Kerja Dengan Menggunakan Anggaran (Studi Kasus Pada KSPPS BMT Mitra Muamalah Jepara)
Authors: Fatmawati Dewi , Aliyah Siti
Published: February 2023

Penelitian ini bertujuan untuk mengetahui bagaimana mekanisme pengendalian biaya tenaga kerja menggunakan anggaran pada KSPPS BMT Mitra Muamalah Jepara. Penelitian ini menggunakan jenis penelitian field reasearch dengan pendekatan kualitatif. Sumber data diperoleh melalui data primer dan data sekunder dengan teknik pengumpulan data baik wawancara, observasi maupun dokumentasi. Kemudian dilakukan uji keabsahan data melalui triangulasi sumber, teknik, dan waktu. Data yang terkumpul dianalisis dengan meredukasi data, penyajian dan kesimpulan. Hasil penelitian ini yaitu prosedur penyusunan anggaran pada KSPPS BMT Mitra Muamalah Jepara menggunakan metode bottom-up approach yang berarti masing-masing dari kantor cabang memberikan usulan yang diajukan oleh perwakilan kantor cabang kemudian secara terpusat usulan tersebut akan direkap dan akan dibahas untuk mendapatkan hasil putusan anggaran biaya tenaga kerja, kemudian RAPB tersebut akan disahkan oleh dewan pengurus dan direktur utama yang pelampiran dan pelaporannya disampaikan pada saat Rapat Anggota Tahunan (RAT) berlangsung.
Persepsi Masyarakat Tentang Sertifikasi Tanah Wakaf Di Dusun Sarampu I Desa Kuajang
Authors: Nurbaeti Nurbaeti , Sappeami Sappeami , Ahmad Burhanuddin , Nurfitriani Nurfitriani
Published: February 2023

Permasalahan yang dikaji dalam penelitian ini adalah: Untuk mengetahui bagaimana persepsi masyarakat tentang Sertifikasi Tanah Wakaf, Jenis penelitian ini adalah penelitian kualitatif, yakni penelitian yang menghasilkan data deskriptif berupa kata - kata tertulis atau lisan dari orang-orang dan perilaku yang diamati. Pengumpulan data dilakukan dengan menggunakan observasi, wawancara mandalam dan dokumentasi. Dengan begitu peneliti mencari tau data-data tanah wakaf mengenai tanggapan atau pengetahuan masyarakat tentang Tanah Wakaf di Masjid Al-Ma’arif Sarampu. Hasil penelitian menunjukkan Dusun Sarampu I masih ada sebagian masyarakat yang belum mengetahui akan pentingnya sertifikasi tanah wakaf, dan masih banyak yang belum mengetahui mengenai prosedur pembuatan Sertifikasi Tanah Wakaf dari Kantor Badan Pertanahan Nasional (BPN), adapun Tanah Wakaf di Dusun Sarampu I belum bersertifikasi, tapi sudah di ukur oleh Badan Pertanahan Nasional (BPN) pada tahun 2013, dan sampai saat ini Sertifikasi Tanah Wakaf tersebut belum terbit, hal ini dikarenakan kurangnya perhatian Nadzir dalam penerbitan Sertifikasi Tanah Wakaf tersebut.
Pengaruh Penyembelihan Halal Terhadap Perilaku dan Kepuasan Konsumen
Authors: Putra Awang Darmawan , Desiana Rina , Alhalim Muhammad
Published: February 2023

Sumber Daya Manusia dalam kehidupan sehari-hari tidak pernah terlepas dengan pemenuhan kebutuhan atau konsumsi.  Aceh merupakan daerah yang sangat berpegang teguh pada syariat Islam, mayoritas masyarakat Aceh sebagai Muslim sudah seharusnya memiliki kesadaran sepenuhnya terkait kehalalan apa yang dikonsumsi. Penelitian ini bertujuan untuk menganalisis pengaruh penyembelihan halal terhadap perilaku dan kepuasan konsumen pada salah satu pasar di Provinsi Aceh. Penelitian menggunakan metodologi dengan pendekatan kuantitatif. Berdasarkan hasil penelitian yang dilakukan terhadap 100 responden maka dapat disimpulkan bahwa variabel penyembelihan halal berpengaruh secara parsial terhadap perilaku dan kepuasan konsumen.
«Pocos campos de investigación y formación como el nuestro»
Authors: Montiel Paty , Casas Rosalba
Published: February 2023

En esta entrevista que Paty Montiel le realiza a la destacada investigadora mexicana, Rosalba Casas, se presenta una reflexión de las relaciones profesionales y personales que le han permitido contribuir al desarrollo de los estudios de ciencia, tecnología y sociedad (CTS) en América Latina. A través de una conversación abierta, y en ocasiones íntima, Casas nos permite conocer cómo encuentros desarrollados durante la juventud de muchos investigadores destacados de hoy, continúan a la fecha. Y es que son precisamente esas relaciones las que han empujado publicaciones, campos académicos y relaciones profesionales. El desarrollo de los estudios CTS ha evolucionado a través de debates académicos que se conjugan con relaciones personales dentro de un marco político y social. Hacia el final de la conversación, Casas reflexiona sobre cómo la especificidad multidisciplinaria de los CTS, más que un obstáculo, son la puerta de entrada para poder influir en la elaboración de políticas públicas más holísticas.
«Podríamos tener sujetos mejor informados y más críticos de los impactos de las tecnologías»
Authors: Vizuete-Sandoval Daniel , Belén Albornoz María
Published: February 2023

María Belén Albornoz comparte en esta entrevista su trayectoria en el campo de los estudios de ciencia, tecnología y sociedad (CTS). En primer lugar, nos da a conocer los diálogos e intercambios con investigadores de varias latitudes y tradiciones intelectuales, y luego nos cuenta su experiencia en el campo de las políticas públicas. A su vez, nos da su mirada sobre el campo CTS en Ecuador y América Latina. Cuando le preguntamos sobre las agendas de investigación y la importancia de los estudios CTS, Albornoz señala que la pandemia por COVID-19 fue un proceso excepcional que mostró la estrecha relación entre tecnologías y sociedad, y también al Estado como un actor clave en la estabilización de tecnologías. Albornoz promueve con urgencia una mirada crítica de la tecnología, tanto para el campo de estudios como para la sociedad.
“Não estão percebendo a importância da policy e da politics de ciência e tecnologia para mudar o mundo”
Authors: Coggo Cristofoletti Evandro , Dagnino Renato
Published: February 2023

Nesta entrevista, Renato Dagnino convida-nos a refletir sobre a importância de conectar os estudos de Ciência, Tecnologia e Sociedade às necessidades da maioria da população brasileira e a um desenvolvimento a partir do que chama de reindustrialização solidária. Para isso, sob a influência do marxismo e do Pensamento Latino Americano em Ciência, Tecnologia e Sociedade, pontua a necessidade de reprojetar a tecnociência capitalista na direção da tecnociência solidária. Dagnino fala também sobre os problemas da universidade latino-americana e brasileira. Destaca, aqui, seu caráter de enclave numa sociedade com a qual não dialoga, e que se reproduz pela emulação das agendas de ensino, pesquisa e extensão dos países centrais. Referindo-se à comunidade de pesquisa em Estudos de ciência, tecnologia e sociedade, ele aponta a necessidade de que ela se dedique mais a pensar a policy e a politics que pode alavancar uma política cognitiva coerente com o cenário que o povo brasileiro está construindo.
«El desarrollo hay que redefinirlo en términos de la capacidad de resolver problemas»
Authors: Harman Canalle Úrsula , Sagasti Francisco
Published: February 2023

En esta entrevista, Francisco Sagasti cuenta los grandes retos, lecciones aprendidas y logros que ha vivido en su larga trayectoria, desde sus inicios como precursor del pensamiento latinoamericano en ciencia, tecnología y sociedad (PLACTS), hasta su reciente condición de expresidente del Perú. A la luz de las profundas desigualdades de su país, Sagasti reflexiona sobre el modelo lineal de innovación, la importancia de invertir en recursos humanos para promover la ciencia, tecnología e innovación (CTI) y la necesidad de articular las ciencias sociales con otras ciencias para repensar el desarrollo. Finalmente, desde su estatus de expresidente, Sagasti cuenta cómo logró poner la CTI al servicio de la sociedad durante la pandemia, resaltando los grandes retos por superar y las increíbles oportunidades provenientes de la gran diversidad cultural y biológica para propiciar un desarrollo más inclusivo en el Perú.
Multiple independent gene disorders causing Bardet--Biedl syndrome, congenital hypothyroidism, and hearing loss in a single Indian consanguineous patient
Authors: Barcelos Isabella , Li Dong , Watson Deborah , McCormick Elizabeth M. , Elden Lisa , Aleman Thomas , O'Neil Erin , Falk Marni J. , Hakonarson Hakon
Published: February 2023

We report a 20-year-old female, adopted Indian patient with over 662 Mb
regions of homozygosity who presented with variants associated with
symptoms in BBS6, STRC, and DUOX2 genes. And a VUS in the TNNT2 gene, so
far without clinical correlation. Symptoms are not explained by only one
gene.
Recent Advances in Glycoprotein Synthesis: A Refined Synthetic Probe towards the Biological World
Authors: Zhuang Haoru , Qiu Yongshun , Hao Huiran , Gan Jinjuan , Li Tianlu
Published: February 2023

Protein glycosylation is the most complex and diverse form of
post-translational modification in human body. Meanwhile, glycosylation
of peptides and proteins emerges as a promising strategy to improve the
pharmacokinetic profile of peptide- and protein-based therapeutics.
Owing to the importance of protein glycosylation, rigorous evaluation of
the relationship between the precise structure and biological function
of glycoproteins has to be per-formed. Recently, chemical synthesis,
chemoenzymatic synthesis and semisynthesis strategy have attracted
extensive attentions towards the prepara-tion of structurally defined
glycopeptides and glycoproteins; the obtained synthetic glycoforms thus
enable the thorough investigation of specific effects of protein
glycosylation. This review highlights the recent progress in the
development of novel strategies, preparation of homogeneous
glycoproteins and exploration of structure-activity relationships. On
this basis, the challenges and prospects are discussed.
Using Fourier transform to connect phenotype and fitness of complex traits
Authors: Dai Yi , Pei Shaojun , Chen Mengmeng , Chen Goutao , Shi Guohui , Yau Stephen S.-T. , Wu Qi
Published: February 2023

The response of traits and trait-related fitness to natural selection is
crucial for the study of natural selection in populations. In this
paper, we used a complex number to describe a quantitative trait, in
which the frequency in a population and the fitness of the trait denote
the modular square and the argument of the complex number. Based on this
description, we introduced Fourier transform to relate the population
distribution of a quantitative trait with the population distribution of
its fitness and applied the uncertainty principle of the Fourier
transform to describe the response of trait and fitness to natural
selection in an inequality. This formula showed that under certain
selection conditions, there was a minimum in the combined response of
the fitness and the trait to the selection, which we called the
principle of least response (PLR) to natural selection. It was suitable
for the long-term evolutionary dynamics of polygenic adaptation,
allowing for gene interactions (epistatic effects), not requiring the
assumption of a normal distribution of traits in a population, and using
only the variance of phenotype and fitness without the need to use
complex statistics such as higher-order moments. The simulation results
verified the high accuracy of the inequality relation in the case of a
single population size. We hoped that this point could throw novel light
on the theoretical basis of the evolution of complex traits.
A Hurst-based Diffusion Model using Time Series Characteristics for Influence Maximization in Social Networks
Authors: Chamola Vinay , Saxena Bhawna , Saxena Vikas , Anand Nishit , Hassija Vikas , Hussain Amir
Published: February 2023

Online Social Networks (OSNs) have grown exponentially in the
last few years due to their applications in real life like marketing,
recommendation systems, and social awareness campaigns. One of the most
important research areas in this field is Influence Maximization (IM).
IM pertains to finding methods to maximize the spread of information (or
influence) across a social network. Previous works in IM have focused on
using a pre-defined edge propagation probability or using the Hurst
exponent (H) to identify which nodes to be activated. This is calculated
on the basis of self-similarity in the time series depicting a user’s
(node) past temporal interaction behaviour. In this work, we propose a
Time Series Characteristic based Hurst-based Diffusion Model (TSC-HDM).
The model calculates Hurst Exponent (H) based on the stationary or
non-stationary characteristic of the time series. Furthermore, our model
selects a handful of seed nodes and activates every seed node’s inactive
successor only if H>0.5 . The process is continued until
the activation of successor nodes is not possible. The proposed model
was tested on 4 datasets - UC Irvine messages, Email EU-Core, Math
Overflow 3, and Linux Kernel mailing list. We have also compared the
results against 4 other Influence Maximisation models - Independent
Cascade (IC), Weighted Cascade (WC), Trivalency (TV), and Hurst-based
Influence Maximisation (HBIM). Our model achieves as much as 590%
higher expected influence spread as compared to the other models.
Moreover, our model attained 344% better average influence spread than
other state-of-the-art models.