bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОШИРЕНІСТЬ ЕНДОКРИННИХ РОЗЛАДІВ У ПАЦІЄНТІВ З ХРОНІЧНОЮ ХВОРОБОЮ НИРОК VД СТАДІЇ
Authors: Dudar Iryna , Savchuk Valentyna , Loboda Оlena , Gonchar Yuriy , Shifris Iryna , Krot Victor , Krasyuk Eduard
Published: September 2021

Мета. Вивчити структуру та поширеність ендокринних розладів (дисфункція щитоподібної залози, гіперпролактинемія) у хворих на ХХН VД ст.Матеріали і методи. У проспективне когортне дослідження включено 118 хворих на ХХН VД стадії, які отримують лікування гемодіалізом (ГД) або перитонеальним діалізом (ПД). У всіх хворих (98 на ГД та 20 пацієнтів на ПД) визначали вміст в сироватці крові тиреотропного гормону (ТТГ), Т4 (тироксин вільний), Т3 (трийодтиронін вільний) та пролактину (ПЛ). Ультразвукове дослідження щитоподібної залози було проведено у 92 хворих на ГД та 19 хворих на ПД.Результати та їх обговорення. Частка хворих на гіпотиреоз становила 23,7%. При цьому явний гіпотиреоз діагностовано у 21 особи (17,8%) та у 7 осіб (5,9%) субклінічний гіпотиреоз. Поширеність гіпотиреозу в нашому спостереженні перевищує показники поширеності гіпотиреозу в загальній популяції в Україні – 6,4%. Синдром «низького» Т3 (низький рівень Т3 при нормальному ТТГ, Т4) встановлено у 29 пацієнтів (24,6%). Рівень ПЛ в сироватці крові був підвищеним у 93 (78,8%) хворих та у 25 (21,2%) не відрізнявся від нормальних значень. Зміни ехографічної картини щитоподібної залози діагностовано з 111 обстежених у 81 пацієнтів (73%). За ознаками УЗД ЩЗ 29 пацієнтів (26,1%) мали ознаки тиреоїдиту, 37 (33,3%) – одновузловий зоб, 44 (39,6%) – багатовузловий зоб. Статистично значущої відмінності в розповсюдженості УЗД змін у ГД-хворих та ПД-хворих не було (χ2 1,8, р> 0,05).Висновки. Ендокринні порушення, зокрема гіпотиреоз, синдром «низького» Т3, гіперпролактинемія є поширеними у пацієнтів, які лікуються нирковою замісною терапією та потребують подальшого вивчення.
ЖИТИ ДОБРЕ З ХВОРОБОЮ НИРОК – ГАСЛО ЦЬОГОРІЧНИХ ЗАХОДІВ ДО ВСЕСВІТНЬОГО ДНЯ НИРКИ-2021
Authors: Moyseyenko Valentyna
Published: September 2021

Вступ. Всесвітній день здоров’я (World Health Day) відзначається щорічно 7 квітня в день його створення в 1948 році Всесвітньою організацією охорони здоров’я (World Health Organization, WHO). За час, що минув з того історичного моменту, членами Всесвітньої організації охорони здоров’я (ВООЗ) стали 194 держави світу. Щорічне проведення Дня здоров’я стало традицією з 1950 року.Мета. Привернути увагу світової спільноти та звичайних громадян до профілактики та обізнаності про хронічну хворобу нирок.Матеріали і методи. Організація і проведення конференцій, круглих столів, майстер-класів, дискусій щодо своєчасної діагностики, маніфестації, перебігу, клінічних ознак хронічної хвороби нирок.Результати та їх обговорення. Цьогоріч в м. Києві у рамках Всесвітнього Дня нирки-2021 відбулися заходи з нагоди Всесвітнього Дня нирки «Жити добре з хворобою нирок»: під егідою ДУ «Інститут нефрології НАМН України», Української Асоціації нефрологів, Національного ниркового фонду та за ініціативи Національної медичної академії післядипломної освіти імені П.Л. Шупика – науково-практичні конференції.На конференціях були представлені доповіді про причини формування, діагностику та лікування хронічної хвороби нирок. До заходів з нагоди Всесвітнього Дня нирки-2021 у дистанційному режимі долучилися молоді науковці Національного медич- ного університету імені О.О. Богомольця.Висновки. Заходи Дня проводяться для того, щоб люди могли зрозуміти, як багато значить здоров’я в їхньому житті. А організації охорони здоров’я та лікарі покликані вирішити питання, що їм потрібно зробити, щоб здоров’я людей в усьому світі стало краще.
Dampak Penambangan Pasir Terhadap Kelestarian Lingkungan Di Kelurahan Tumbihe
Authors: Hulukati Melviyana , Isa Abd. Hamid
Published: August 2021

Permasalahan dalam penelitian ini adalah bagaimana dampak penambangan pasir terhadap kelestarian lingkungan di Kelurahan Tumbihe Kecamatan Kabila. Penelitian ini bertujuan untuk mendeskripsikan dampak penambangan pasir terhadap kelestarian lingkungan di Kelurahan Tumbihe Kecamatan Kabila.Untuk mendapatkan jawaban terhadap permasalahan di atas, peneliti menggunakan metode kualitatif, teknik pengumpulan data dalam bentuk observasi, teknik wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa dampak penambangan pasir terhadap kelestarian lingkungan di Kelurahan Tumbihe Kecamatan Kabila Kabupaten Bone Bolango pada dasarnya memberi dampak positif berupa penambahan pendapatan bagi penambang dan mudahnya terpenuhi material pasir lokal dengan harga lebih murah dan waktu pemesanan yang singkat. Disisi lain dampak negatif yang dirasakan masyarakat lebih banyak melalui usaha penambangan pasir tersebut yang dapat mengakibatkan kerusakan lingkungan berupa rusaknya lahan sekitar masyarakat, terganggunya flora dan fauna, terganggunya kesehatan dan keamanan penduduk, lahan rawan longsor  dan potensi terjadinya banjir, terjadinya polusi udara berupa debu dan pencemaran air bersih, serta jalan menjadi rusak akibat jalur transportasi pengangkut pasir yang melintasi wilayah sekitar penduduk.
Peran Masyarakat Dalam Pengolahan Sampah Di Kelurahan Pentadu
Authors: Iyabu Nadia , Duludu Ummyssalam A.T.A , Zubaidi Mohamad
Published: August 2021

Penelitian ini bertujuan untuk mengetahui Peran Masyarakat Dalam Pengolahan Sampah Di Kelurahan Pentadu Kecamatan Paguat Kabupaten Pohuwato. Jenis penelitian ini menggunakan penelitian kualitatif deskriptif, dan teknik pengumpulan data menggunakan teknik observasi, wawancara dan dokumentasi. Hasil penelitian menunjukkan bahwa ada terdapat beberapa peran yang masyarakat lakukan dalam pengolahan sampah, diantaranya yaitu peran aktif,peran aktif disini yaitu masyarakat yang selalu melakukan pengolahan sampah atau bisa disebut aktif dalam kegiatan pengolahan sampah selanjutnya ada peran partispasif, peran partisipasif yaitu peran yang dilakukan hanya dalam keadaan tertentu jadi masyarakat dalam pengolahan sampah ini mereka hanya melakukan kegiatan tersebut dalam keadaan tertentu atau menyesuaikan dengan kebutuhan masyarakat dan terakhir terdapat peran pasif, peran pasif disini yaitu masyarakat yang tidak pernah melakukan pengolahan sampah. Dapat dilihat dari hasil peneletian bahwa peran yang sangat berpengaruh pada pengolahan sampah ini adalah peran aktif dimana dalam peran aktif ini masyarakat selalu melakukan kegiatan pengolahan sampah.Tujuan dari Pengolahan sampah guna untuk menghindari dampak dari kerusakan lingkungan, menjadikan lingkungan yang bersih bebas dari sampah dan dapat menimbulkan keterampilan-keterampilan yang dapat menghasilkan nilai ekonomi.
A MATHEMATICAL PROPOSED MODEL FOR PUBLIC KEY ENCRYPTION ALGORITHMS IN CYBERSECURITY
Authors: Saif H.A. , Gharib G.M.I. , AL-Mousa M.R.
Published: September 2021

Information security is a very important science, especially after the continuous increase in cybercrime of all kinds, which caused very large financial, economic and political losses, so it was necessary to find a solution to protect the data and keep it secret. Data encryption is one of the most important solutions to preserve data and reduce cybercrime. The encryption process means converting the plain text using a private key into symbols and numbers that make this text incomprehensible to others. There are many algorithms that are used for encryption, and the public key algorithms are the strongest in the encryption process because they depend on two keys, the public key and the private key. One of the most important problems facing this type of algorithm is the lack of a clear mathematical model that facilitates understanding and how to deal with these keys. In this thesis, a mathematical model has been proposed in which two functions are defined, the public key and the function of the private key, based on the concepts and specific characteristics of the function. A general mathematical model was constructed by defining two functions, one for the public key and the other for the private key, using the properties of a function in mathematics, to produce strong keys used in the public key algorithm, to protect data and keep it secret, and this model was applied to the RSA and ELGamal algorithms. The most important result was that in the case of applying the mathematical model, it is easy to understand and deal with the public key and the private key mathematically.
Pengaruh 5C Dan 7P Dalam Pemberian Kredit
Authors: Sasmita Theresia , Puspitasari Ratih , Rosita Siti Ita
Published: September 2021

Analisis 5C dan 7P serta analisis kelayakan merupakan analisis yang dipakai oleh lembaga keuangan/bank dalam mengantisipasi terhadap kredit macet termasuk bagi Bank BNI, Tbk dan Bank BRI, Tbk.Analisis 5C dan 7P memiliki persamaan, yaitu apa-apa yang terkandung dalam 5C dirinci lebih lanjut dalam prinsip 7P di samping lebih terinci juga jangkauan analisisnya lebih luas dari 5C. Prinsip analisis kredit dengan 5C itu sendiri terdiri dari :Character, capaciity, capital, collateral, dan condition. Sedangkan prinsip analisis menggunakan 7P ialah: Personality, Party, Purpose, Prospect, Payment, Protability, dan Protection.
Peranan Customer Servis Dalam Meningkatkan Mutu Pelayanan Pada Sekolah Islam Ibnu Hajar
Authors: Ayu Fini Rizkita Purnama , Srihandoko Wimpi
Published: September 2021

Customer Service merupakan kegiatan yang ditujukan untuk memberikan kepuasaan melalui pelayanan yang diberikan oleh seseorang kepada kliennya dalam menyelesaikan masalah dan memuaskan. Customer Service merupakan salah satu fasilitas yang di berikan pihak sekolah untuk melayani murid dan wali murid, agar para orang tua merasa terfasilitasi dengan baik oleh pihak sekolah.

              Tujuan dari pembuatan tugas akhir ini, untuk mengetahui bagaimana peran Customer Service dalam meningkatkan mutu pelayanan pada Sekolah Islam Ibnu Hajar. dan mengetahui kendala Customer Service dalam meningkatkan mutu pelayanan pada Sekolah Islam Ibnu Hajar. Serta mengetahui strategi pelayanan Customer Service dalam meningkatkan mutu pelayanan pada Sekolah Islam Ibnu Hajar.

                Hasil pembahasan menunjukan bahwa, cara meningkatkan mutu pelayanan adalah dengan mendengarkan dengan sabar semua keluhan dan pertanyaan dari wali murid. Serta bisa mengendalikan emosi jika sebelumnya sudah melayani yang mengeluh, lalu datang yang lain. Tetap tersenyum tidak melampiaskan kepada yang lain dan menerapkan beberapa cara yaitu, dengan bersikap ramah dan komunikatif melayani dengan sepenuh hati,  sehingga wali murid merasa puas dengan pelayanan yang di berikan. Sedangkan kendala-kendala yang di hadapi oleh Customer Service yaitu, Melupakan keluhan yang berlebuhan, minimnya menghargai Customer Service dan tidak sabar ketika menunggu untuk di layani.

Kata Kunci : Customer Service.
Sistem Penagihan Rekening Air Pelanggan Pada Perusahaan Umum Daerah Air Minum Tirta Pakuan Kota Bogor
Authors: Humairoh Adela Putri , Listari Sinta , Syarif Rini
Published: September 2021

Sistem Penagihan Rekening Air Pelanggan merupakan kegiatan penagihan atas tunggakan rekening air yang menerapkan sistem aplikasi SMS Gateway sebagai upaya penagihan, dimana aplikasi tersebut dapat memudahkan bagian penagihan dalam memberikan informasi tunggakan tagihan bagi pelanggan yang telah menunggak selama dua bulan dan tidak berlaku untuk pelanggan yang menunggak selama satu bulan atas pemakaian jasa rekening air. Apabila belum terjadi pelunasan pada tunggakan pelanggan, maka dilakukannya pemutusan saluran air oleh PERUMDA Tirta Pakuan Kota Bogor.

            Tujuan penelitian Tugas Akhir ini adalah untuk mengetahui sistem penagihan rekening air pelanggan pada PERUMDA Tirta Pakuan Kota Bogor. Untuk mencapai sasaran penelitian yang jelas dan terarah maka penulis merumuskan permasalahan mengenai Sistem yang diterapkan dalam  Penagihan Rekening Air Pelanggan, Tahap-tahap Penagihan , Faktor-faktor yang menjadi penyebab atas tunggakan tagihan rekening air serta Kendala yang muncul dalam sistem penagihan dan solusinya.

            Berdasarkan hasil penelitian dan pembahasan tersebut Sistem Penagihan Rekening Air Pelanggan pada PERUMDA Tirta Pakuan Kota Bogor antara lain memberikan informasi tagihan air atas tunggakan pelanggan. Dalam pembahasan tersebut menunjukkan perusahaan sudah memiliki Sistem Penagihan yang baik, sehingga semua aktivitas perusahaan dapat berjalan secara efektif dan efisien.

Kata Kunci : Penagihan, Tunggakan, SMS Gateway
Pengaruh Kualitas Perangkat Desa Terhadap Kualitas Laporan Keuangan Desa
Authors: Wahyudi Agus , Hasri Diah Anggeraini
Published: September 2021

This study aims to examine the effect of the quality of village officials on the quality of village financial reports at the village government in Utan District, Sumbawa Regency. This type of research is quantitative research with an associative approach. The data collection technique is using a questionnaire. The number of samples in this study amounted to 36 respondents consisting of the village head, the head of the village consultative body, the village secretary, and the village treasurer. The results showed that the quality of village officials had a positive and significant effect on the quality of village financial reports, with the existence of quality village officials it would produce quality financial reports. The results of the determination test showed that 58.2% of the village financial report quality variables could be explained by the village apparatus quality variable, the rest was influenced by other variables that were not included in this study.
Pengaruh Profitabilitas, Leverage, Ukuran Perusahaan Terhadap Tax Avoidance Perusahaan Property dan Real Estate
Authors: Hermawan Sakti , Sudradjat Sudradjat , Amyar Firdaus
Published: September 2021

Financial statements are used by many parties to determine the condition of the company's financial performance. Financial statements are a very important source of information in assessing the company's performance and prospects for shareholders and the public as one of the bases in making investment decisions. The value of the information contained in financial statements can be affected by the timeliness of preparation and presentation of financial statements. Because of this, the timeliness of a company in compiling and presenting its financial statements is very important. The company's timeliness in preparing financial statements can be influenced by several things, both internal and external influences.

This study was conducted with the aim of knowing whether Profitability, Leverage and Company Size have an influence on Tax Avoidance in Property and Real Estate companies listed on the Indonesia Stock Exchange (IDX) for the 2017-2019 period. Previous research that has been done shows different results. Therefore, it is necessary to conduct another study with the aim of re- testing the theory of Tax Avoidance.

The population of this research is 46 property and real estate companies. This study uses a purposive sampling method in taking samples, so that 31 sample companies are obtained for 3 years of observation (2017-2019) with

93 observations (observations). Research data obtained from sample companies which can be downloaded on the official website of the Indonesia Stock Exchange. This study uses descriptive statistical analysis and multiple linear regression analysis as data analysis techniques. The data analysis technique carried out first is descriptive statistical analysis, classical assumption test, multiple linear regression analysis and then hypothesis testing.
Pengaruh Likuiditas Dan Perputaran Modal Kerja Terhadap Profitabilitas Pada PT Smart Tbk. Periode Tahun 2011-2019
Authors: Sofyan Nur Annisa Oktaviani , Alamsyah Richad
Published: September 2021

The development of the era of globalization has made the business world in Indonesia continue to grow so that it has increased significantly from year to year. This is an attraction that spurs investors to invest their capital, especially with the implementation of free trade which encourages investors to take business units in various parts of the world or become new competitors in similar industries. Competition that occurs requires companies to be more competitive so as not to lose to compete with other companies. Therefore, to maintain the survival of the company and generate optimal profits, the company must be able to manage its finances well, meaning that financial management policies must be able to ensure the company's business continuity, by increasing all company activities and optimizing the resources they have properly. must be smart and fast in taking appropriate steps to anticipate the development of the business world with productivity competitiveness based on production efficiency and effectiveness.

This study aims to obtain findings about (1) the effect of liquidity and working capital turnover partially on profitability, (2) the effect of liquidity and working capital turnover simultaneously on profitability.

The type of data used in this study is secondary data, namely the quarterly financial statements of PT SMART Tbk for the period 2011-2019. The analysis used in this study is multiple linear regression analysis using the Statistical Package for Social Sciences (SPSS) version 25 program. The total sample used by the author is 36 data.

The results showed that liquidity had an effect on profitability. Working capital turnover has no effect on profitability. Liquidity and working capital turnover together have a positive effect on company profitability.

 

 

Keywords: Liquidity, Working Capital Turnover, Profitability
Pengaruh Likuiditas, Profitabilitas, Dan Pertumbuhan Perusahaan Terhadap Penerimaan Opini Audit Going Concern Perusahaan Farmasi
Authors: Zaelani Muhamad , Amrulloh Amrulloh
Published: September 2021

Kelangsungan hidup suatu perusahaan selalu melekat pengaruhnya dengan pentingnya peran manajemen bisnis suatu perusahaan dalam mengelola perusahaan tersebut agar terus bisa berjalan dan berkembang, selain peran manajemen keberlangsungan perusahaan juga melebar pada peran auditor terkait perusahaa tersebut, karena auditor bertanggung jawab untuk selalu mengevaluasi kinerja serta status keberlangsungan hidup perusahaan (Alichia, 2008)..

 

Penelitian ini merupakan penelitian untuk menguji pengaruh Likuiditas, Profitabilitas, dan Pertumbuhan perusahaan terhadap penerimaan opini audit going concern. Penelitian ini merupakan penelitia kuantitatif dengan metode analisis korelasi, dimana peneliti menunjukkan beberapa hubungan variabel tertentu. Hasil dari seleksi data dengan menggunakan metode purposive sampling, yaitu teknik pengambilan sampel dengan menggunakan kriteria tertentu seperti perusahaan Farmasi yang tercatat di Bursa Efek Indonesia (BEI) pada tahun 2017 sampai dengan 2019 dengan sampel perusahaan sebanyak 8 perusahaan dan sample laporan keuangan yang digunakan sebanyak 24 laporan keuangan. Teknik analisis data yang digunakan yaitu teknik analisis regresi logistik, dengan menggunakan program SPSS 26.

 

Hasil dari analisis regresi menunjukkan bahwa dari tiga hipotesis yang diuji menyatakan bahwa variabel Likuiditas, Profitabilitas, dan Pertumbuhan Perusahaan mendukung hipotesis. Jadi, Ketiga Variabel tersebut tidak mempengaruhi auditor dalam pemberian opini audit going concern.

 

 

Kata kunci: Opini Audit Going Concern, Likuiditas, Profitabilitas, dan Pertumbuhan Perusahaan
Pengaruh Promosi melalui Sosial Media dan Online Customer Reviews Terhadap Keputusan Pembelian
Authors: Putra Rendy Dwi , Setiawan Budi
Published: September 2021

Penelitian ini bertujuan menguji pengaruh antara Promosi melalui Sosial Media dan Online Customer Reviews Terhadap Keputusan Pembelian ( Studi Kasus Marketplace Zomato pada Generasi Millenial di Kota Bogor ). Penelitian ini menggunakan variable independent yaitu Promosi melalui Sosial Media dan Online Customer Reviews. Variabel dependennya adalah Keputusan Pembelian. Data dalam penelitian ini merupakan data sekunder.

Sampel penelitian ini adalah konsumen yang sudah membeli makanan dan minuman di restoran atau kafe melalui aplikasi Zomato. Sampel dilakukan dengan metode Hair et al sampling. Pengumpulan data dilakukan dengan kuisioner disebarkan langsung kepada konsumen yang telah membeli makanan dan minuman di restoran atau kafe melalui aplikasi Zomato sebanyak 130 responden. Metode statistic menggunakan analisis regresi linear berganda, dengan pengujian hipotesis uji statistik t.

Hasil penelitian ini menjukan positif dan signifikan pada variable Promosi melalui Sosial Media dengan t-hitung lebih besar dari t-tabel (2,779>1,96) dan variabel Online Customer Reviews t-hitung lebih besar dari t-tabel (5,349>1,96).

 

Kata Kunci : Promosi melalui Sosial Media, Online Customer Reviews, Keputusan Pembelian.
Pengaruh Nilai Tukar, Suku Bunga dan Inflasi terhadap Indeks Harga Saham Gabungan
Authors: Paryudi Paryudi
Published: September 2021

ABSTRACT

 

This study aims to determine the effect of exchange rates, Interest Rates Sertificates of Bank Indonesia and inflation on the Composite Stock Price Index in the  Indonesian stock exchange. The sampling technique was purposive sampling. The samples obtained were 60 samples. Based on the results of data analysis, it shows that the exchange rate has a negative and significant effect on the Composite Stock Price Index. Interest Rates Certificates of Bank Indonesia and Inflation has a negative and unsignificant effect on the Composite Stock Price Index. Collectively exchange rate, Interest Rates, Certificate of Bank Indonesia and inflation have a positive and significant effect on the Composite Stock Price Index.

 

Keywords: Exchange rates, Interest Rates Certificates of Bank Indonesia, inflation and Composite Stock Price Index.

ABSTRAK

 

Penelitian ini bertujuan untuk mengetahui pengaruh Nilai Tukar, Suku Bunga SBI dan Inflasi terhadap Indeks Harga Saham Gabungan di Bursa Efek Indonesia. Teknik pengambilan sampel adalah purposive sampling. Sampel diperoleh sejumlah 60 sampel. Berdasarkan hasil analisis data menunjukan bahwa Nilai Tukar berpengaruh negatif dan signifikan terhadap Indeks Harga Saham Gabungan, Suku Bunga SBI dan Inflasi berpengaruh negatif dan tidak signifikan terhadap Indeks Harga Saham Gabungan. Secara bersama Nilai Tukar, Suku Bunga SBI dan Inflasi berpengaruh positif dan signifikan terhadap Indeks Harga Saham Gabungan.

Kata Kunci : Nilai Tukar, Suku Bunga SBI, Inflasi dan IHSG.
MS TREATMENT OPTIMIZATION: FACTORS ASSOCIATED WITH POOR CLINICAL RESPONSE IN NAB POSITIVE PATIENTS
Authors:   Department of Neurology, University of Medicine and Pharmacy “V. Babes”, Timisoara, Cornea A. , Tudor R. ,   Department of Neurology, University of Medicine and Pharmacy “V. Babes”, Timisoara,   Clinic II of Neurology, Clinical County Emergency Hospital “Pius Brinzeu”, Timisoara, Petre A. ,   Department of Neurology, University of Medicine and Pharmacy “V. Babes”, Timisoara, Simu M. ,   Department of Neurology, University of Medicine and Pharmacy “V. Babes”, Timisoara,   Clinic II of Neurology, Clinical County Emergency Hospital “Pius Brinzeu”, Timisoara
Published: September 2021

Background and purpose. Interferon beta (IFN beta) belongs to the first line of disease modifying therapy drugs in the treatment of relapsing-remitting multiple sclerosis being widely used in the chronic treatment of this pathology. The serum presence of the neutralizing antibodies (Nabs) has been shown to alter the treatment response, its routine applicability being still debated. In an observational study, we aimed to determine in the Nabs positive patients, correlations with other clinical factors which contribute to IFN beta decreased efficacy. Methods. We measured Nabs in 104 patients who were on IFN beta therapy (29.8% on IFN beta 1a s.c., 27.88% on IFN beta 1a i.m. and 42,3 on IFN beta 1b s.c.) for at least one year in our clinic. Serum was collected at 24 h after treatment injection to avoid transitory antibody peak (12-18 h post administration). We considered positive the patients with a titer higher than 20 TRU. Results. The prevalence of Nabs in our group of patients was 13.43% (42.85% IFN Beta 1b s.c., 50% IFN beta 1a s.c. and 7.14% IFN beta 1 a i.m.). Nabs positivity was associated with an increase in the relapse rate (for IFB beta 1a and 1b s.c. groups) and progression for IFN beta 1 b s.c. patient group. Conclusions. The routine clinical testing for Nabs should impact the clinical decision of switching therapy in multiple sclerosis patients that present with an increased number of relapses, EDSS progression or a higher number of MRI T2 lesions.
NEW INSIGHTS IN THE NATURAL HISTORY OF EARLY-ONSET MULTIPLE SCLEROSIS
Authors:   Department of Neurology I, County Emergency Hospital of Cluj, Cluj-Napoca, Homorodean Romana , Perju-Dumbrava Lacramioara ,   Department of Neurology I, County Emergency Hospital of Cluj, Cluj-Napoca,   “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca
Published: September 2021

Background. The early onset forms of Multiple Sclerosis (Paediatric MS, P-MS) have a low frequency, occurring in 2% to 10% of all MS cases. Age at diagnosis is a key feature for disease progression and prognosis in MS patients. Objective. To evaluate the clinical features and course of MS in patients having the disease onset before the age of 18, according to age at diagnosis. Methods. Patients with MS onset before age of 18 identified from Basse-Normandie MS regional registry, were included in the study. Patients were divided in two groups according to the age at MS diagnosis: the first group (group A) of patients in whom MS diagnosis was set before age of 18 and the second group (group B) including patients older than 18 years at MS diagnosis. Data related to clinical features and disease course were evaluated and compared between the two groups and also with some clinical data of adult MS patients included in the same regional database. Results. A total of 41 patients with P-MS were included in the study, represented by 20 patients in group A and 21 patients in group B. Patients from group A had a more rapid progression to mild handicap (EDSS 3.0) than patients from group B (time to reach EDSS 3.0 of 6.34 vs 14.36 years; p=0.02) and they reached this level of disability at a younger age (21.17 vs 29.79 years; p=0.002). The duration of the first remission was significantly shorter in group A (1.44 vs 5.14 years; p<0.001) and the evolution to secondary-progressive (SP) form was faster when compared to group B (14.97 vs 27.57 years; p=0.01). Patients from group A had a greater risk to reach EDSS 3.0 or EDSS 6.0 as well as a greater probability to reach SP form (p<0.001) than patients from group B. Progression index (PI) of the entire paediatric group was significantly lower than mean PI in the adult group (0.29 vs 0.45; p=0.003) but not significantly different between the two groups (0.37 in group A vs 0.21 in group B). Conclusion. P-MS forms show some clinical peculiarities, especially those with the age of diagnosis less than 18 years. They seem to have a more severe clinical MS course and a faster progression of disability.
OBSERVATIONAL STUDY REGARDING RISK FACTORS AND COMORBITITES FOR CHRONIC KIDNEY DISEASE IN DIABETES MELLITUS PATIENTS FROM BIHOR COUNTY
Authors:   “Dr. G. Curteanu” Municipal Clinical Hospital, Oradea, Romania, Baidog Adriana ,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Vesa Cosmin ,   Clinical County Emergency Hospital of Oradea, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Ratiu Ioana ,   “Dr. G. Curteanu” Municipal Clinical Hospital, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Sabau Monica ,   Clinical County Emergency Hospital of Oradea, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Galusca Dorina ,   “Dr. G. Curteanu” Municipal Clinical Hospital, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Bako Gabriel ,   “Dr. G. Curteanu” Municipal Clinical Hospital, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania, Popa Amorin ,   Clinical County Emergency Hospital of Oradea, Oradea, Romania,   University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania
Published: August 2021

Introduction. Chronic kidney disease is a common comorbidity in diabetes mellitus type 2 patients because of presence of numerous risk factors such as obesity, hypertension, hyperglycemia and dyslipidemia. Material and methods. Our retrospective, observational study included 300 patients with type 2 diabetes mellitus from Bihor County and had the purpose to establish a clinical profile and to determine the risk factors associated with this pathology. Results. The prevalence of CKD was 75.67%. Older age, worse glucose control, presence of diabetic polyneuropathy and diabetic retinopathy, higher weight, past history of cardiovascular events, the presence of metabolic syndrome and hyperuricemia were associated with the presence of CKD. Conclusion. The clinical characteristics of type 2 diabetes mellitus patients with CKD is significantly worse compared with the population without CKD.
SERUM LEPTIN LEVELS AND PANCREATIC ENDOCRINE FUNCTION IN BARIATRIC PATIENTS
Authors:   Medical Laboratory, Bethany Medical Clinic Oradea, Bihor County, Romania, Dejeu Paula , Dejeu Viorel ,   General Surgery, “Dr. Gavril Curteanu” City Hospital, Oradea, Romania,   General Surgery, MedLife Genesys Hospital, Arad, Romania, Dejeu Dănuț ,   General Surgery, “Dr. Gavril Curteanu” City Hospital, Oradea, Romania,   General Surgery, MedLife Genesys Hospital, Arad, Romania, Bembea Marius ,   Pediatrics and Clinical Genetics, “Dr. Gavril Curteanu” City Hospital, Oradea, Romania,   Faculty of Medicine and Pharmacy, University of Oradea, Romania
Published: August 2021

Background. Leptin is a hormone synthetized and secreted by the adipose tissue, with a regulating role in the neuro-endocrine-metabolic functions in humans during fasting. Obesity associates metabolic syndrome which combines a leptin resistance status with an insulin resistance status, a disorder that increases the risk of occurrence of type 2 diabetes mellitus. After the bariatric treatment, the decrease of leptin levels in obese patients improves the endocrine function of the pancreas and decreases the risk of developing type 2 diabetes mellitus over time. Aim. In the present study, we have monitored the dynamics of the serum values of leptin, insulin and glucose in correlation with the decrease of BMI (body mass index) after the bariatric surgery. Material and methods. Glucose, insulin and leptin serum levels were assessed in 48 obese individuals before and at 6 months after the bariatric surgery. Results. Leptin and insulin serum levels are decreasing significantly along with the decrease of BMI and pancreatic beta cells optimize their endocrine functionality. Conclusion. Pancreatic endocrine function in obese individuals who undergo bariatric treatment improves significantly at 6 months after the surgery procedure.
THE CORRELATION BETWEEN THE APPEARANCE OF NON-MELANOCYTIC SKIN TUMORS AND EXPOSURE TO UV RADIATION
Authors:   Cabinet medical Individual Dr. Ioana Veronica Grăjdeanu, București, Cioti Ana-Maria , Nicolescu Oana ,   Medicină de familie, Universitatea de Medicină și Farmacie “Carol Davila”, București, Grăjdeanu Ioana Veronica ,   Medicină de familie, Universitatea de Medicină și Farmacie “Carol Davila”, București, Stefanescu Alexandru Mihai ,   Spitalul Clinic ”Nicolae Malaxa“, București, România, Obilisteanu Gabriela Carmen ,   Spitalul Clinic ”Nicolae Malaxa“, București, România, Simionescu Anca Angela ,   Obstetrică și Ginecologie, Universitatea de Medicină și Farmacie ”Carol Davila” București, România,   Spitalul Clinic ”Filantropia”, București, România, Stănescu Ana Maria Alexandra ,   Medicină de familie, Universitatea de Medicină și Farmacie “Carol Davila”, București
Published: August 2021

Introduction. In the last 30 years, the incidence of non-melanocytic skin tumors (NMRTs) has increased alarmingly. The most common subtype of TCNM is basal cell carcinoma followed by squamous cell carcinoma. Material and method. This retrospective study was performed on a group of 140 patients. Patients diagnosed with C44 nonmelanocytic malignancy according to ICD-10 were included in the study. Results. Of the 140 patients, 118 (84%) received the presumptive diagnosis of CBC and 17 (12%) the diagnosis of CSC. Histopathological examination confirmed the diagnosis of CBC in 76% of cases and that of CSC in 58% of cases. Regarding the number of lesions, cases with a single lesion predominate (94%). In terms of clinical form, the most common type of basal cell carcinoma in the study group was 75% nodular carcinoma. Conclusions. There is a need for more studies for the application of prevention and proper management from the family doctor to the specialist.
EMERGENCY SURGERY IN COMPLEX INCISIONAL HERNIAS MANAGEMENT
Authors:   Chirurgie Generală, Spitalul Euroclinic, Bucureşti, România, Ristea Roxana-Florina , Sanda Nicoleta-Aurelia ,   Chirurgie Generală II, Spitalul Universitar de Urgenţă, Bucureşti, România, Ion Daniel ,   Chirurgie Generală III, Spitalul Universitar de Urgenţă, Bucureşti, România,   Chirurgie Plastică şi Microchirurgie Reconstructivă, Spitalul Universitar de Urgenţă, Bucureşti, România, Ristea Marius-Răzvan ,   Chirurgie Plastică şi Microchirurgie Reconstructivă, Spitalul Universitar de Urgenţă, Bucureşti, România, Palade Radu Şerban ,   UMF „Carol Davila“, Bucureşti, România
Published: August 2021

Introduction. Complex incisional hernias are a surgical challenge and a current socio-economic problem. In the emergency surgery of this pathology, the surgeon faces the need to obtain a "tension-free" hernia repair being limited in the use of parietal prosthesis due to the frequent needs of opening the gastrointestinal tract and thus contamination of the operating field. Purpose. The aim of this study is to evaluate and adapt emergency surgical treatment in order to reduce the risk of postoperative complications. Material and methods. The present study has a retrospective character and evaluates a group of 390 patients with complex incisional hernias admitted and operated in the General and Emergency Surgery III section of the Bucharest University Emergency Hospital during 2008-2018. Results. We identified 390 patients diagnosed with complex incisional hernias, of whom 95 were presented to the hospital as an emergency.The prosthetic hernioraphy was used in 51 of these patients, and complications were found in 18 patients in the total study group, ranging from wound infection to death. Discussions. The occurrence of postoperative complications was not statistically significantly associated with emergency surgical treatment. Instead, vital complications were much more common in this group. Conclusions. Increasing the degree of information and education of the patient, increasing addressability and avoiding emergency operations for this pathology are long-term objectives in the treatment of complex incisional hernia pathology.
ANTITHYROID ANTIBODIES - A POSSIBLE INVOLVEMENT IN THE DEVELOPMENT OF CHRONIC PERIODONTITIS
Authors:   Circo Dentistry, Bucureşti, România, Circo Razvan , Beciu Marian ,   Disciplina Endocrinologie, Facultatea de Medicină, Universitatea „Ovidius“, Constanţa, România, Raducan Doina ,   Disciplina Endocrinologie, Facultatea de Medicină, Universitatea „Ovidius“, Constanţa, România, Badea Victoria ,   Imunologie, Facultatea de Medicină Dentară, Universitatea „Ovidius“, Constanţa, România
Published: August 2021

Objectives. Identification of periodontal lesions in patients with chronic autoimmune thyroiditis (CAT) assessed differently depending on their severity and the average serum level of thyroid autoantibodies. Material and methods. The study was initiated in a group of patients (n = 133) diagnosed with chronic autoimmune thyroiditis in conditions of normal thyroid function and without other comorbidities. Examination of the oral cavity identified lesions characteristic of chronic periodontitis (CP) classified according to their intensity in - mild, medium and aggravated in a group of 109 patients. The serum level of thyroid autoantibodies – as a mean value – was analyzed in a group of 77 patients with similar periodontal lesions related to their classification. Results. Characteristic ethological changes of chronic periodontitis were identified in 85% of patients being classified as: mild (40.2%), medium (31.9%), aggravated (28.5%). Thyroid autoantibodies were present: 62.3% for antithyroperoxidase antibodies (ATPO), 23.8% for both ATPO and antithyroglobulin antibodies (ATG); 13.7% for ATG. The differentiated statistical calculation of the average values of antibodies found for ATPO presented a high statistical significance (p < 0.0002) for spontaneous bleeding, all degrees of tooth mobility, depth of periodontal pockets, root fork and dental occlusion. No statistical significance was found for ATPO in bacterial plaque and gingival regression. No statistical significance was recorded for the mean level of ATG. Conclusions. The correlation of the serum level of thyroid autoantibodies with the specificity of periodontal lesions certify a possible differentiated involvement of them. For ATPO, extra-thyroid systemic effects can be suggested as a priority.
IDIOPATHIC SCROTAL CALCINOSIS. A CASE REPORT
Authors:   Faculty of Medicine, “Titu Maiorescu“ University of Bucharest, Bucharest, Romania, Rădulescu Ionica-Mariana ,   Regina Maria Private Health Network, Titu Maiorescu Policlinic, Bucharest, Romania, Arghir Ana ,   Faculty of Medicine, “Titu Maiorescu“ University of Bucharest, Bucharest, Romania, Moldovan Cosmin ,   Faculty of Medicine, “Titu Maiorescu“ University of Bucharest, Bucharest, Romania
Published: August 2021

Idiopathic scrotal calcinosis (ISC) is a benign, rare condition with incompletely elucidated etiology. It is clinically characterized by the presence of multiple calcified, asymptomatic nodules, located in the scrotum. The onset of the disease occurs during childhood or young adulthood. We present the case of a patient with idiopathic scrotal calcinosis with onset around the age of 20 years. The peculiarity of the case lies in the rarity of this condition and the fact that the patient came to our clinic about 25 years after the onset of his condition, even though he had multiple nodules, which makes it difficult to diagnose and complicates the promptness of surgery.
PARCELAR GASTRIC RESECTION IN ASSOCIATION WITH BOWEL RESECTIONS AS PART OF DEBULKING SURGERY FOR ADVANCED STAGE OVARIAN CANCER – A CASE REPORT
Authors:   Department of Visceral Surgery, Center of Excellence in Translational Medicine, “Fundeni” Clinical Institute, Bucharest, Romania, Bacalbasa Nicolae ,   Department of Obstetrics and Gynecology, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Balescu Irina ,   Department of Surgery, Ponderas Academic Hospital, Bucharest, Romania, Aloul Adnan Al ,   Department of Surgery, Ramnicu Sarat County Hospital, Buzau, Romania,   Doctoral School, “Titu Maiorescu“ University, Bucharest, Romania
Published: August 2021

Ovarian cancer represents one of the most aggressive gynecological malignancies affecting women worldwide, associated with significant rates of cancer related death within the first years after the initial diagnostic. The poor survival rates are usually explained by the presence of disseminated lesions even from the beginning. In such situations, the digestive tube is one of the most commonly involved territory, therefore necessitating extended resections in order to achieve complete cytoreduction. The aim of this paper is to report the case of a 53 year old patient who was diagnosed with peritoneal carcinomatosis from ovarian cancer, presenting multiple levels of digestive tract involvement due to the presence of disseminated tumoral masses. Therefore the patients was submitted to multiple digestive resections represented by parcelar gastrectomy, segmental ileal resection and subtotal colectomy. In order to minimize the risks of developing severe postoperative complications – due to the relatively high number of anastomoses – the continuity of the digestive tract was established by a terminal ileostomy, considering that creation of a ileorectal anastomosis would be too dangerous in the context of multiple digestive resections. The postoperative evolution was simple, the patient being further submitted to adjuvant treatment.
PREGNANCY IMPLANTED IN THE SCAR OF CAESAREAN SECTION AND THE ROLE OF THE GENERAL PRACTITIONER
Authors:   Departamentul Medicină de Familie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România, Stănescu Ana Maria Alexandra , Grăjdeanu Ioana Veronica ,   Departamentul Medicină de Familie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România, Bejan Gabriel Cristian ,   Departamentul Medicină de Familie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România, Ghilencea Liviu Nicolae ,   Departamentul Medicină de Familie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România, Iancu Mihaela Adela ,   Departamentul Medicină de Familie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România, Simionescu Anca Angela ,   Departamentul de Obstetrică ṣi Ginecologie, Universitatea de Medicină ṣi Farmacie „Carol Davila“, Bucureṣti, România,   Departamentul de Obstetrică-Ginecologie, Spitalul Clinic Filantropia, Bucureṣti, România
Published: August 2021

The increase in the number of cesarean sections led to severe complications, such as the ectopic scar pregnancy and the morbidly adherent placenta. The incidence of scar pregnancy is 1/2000 of pregnancies, the more frequently associated with the higher the number of cesarean sections. These can cause severe bleeding, rupture of the uterus, bladder or digestive injury or maternal mortality. The general practitioner has an important role in the diagnosis and monitoring of these patients. He knows the patient's history, is asked in permanent by it and sometimes is in the situation of being the only one checking pregnancy. This work aims to review the diagnostic and monitoring criteria for ectopic scar pregnancy helpful to family physicians. Addressing all patients with a scarred uterus for early screening ultrasound may increase the rate of diagnosis. The family doctor is an essential partnership in monitoring these high risk cases.
Pengaplikasian Mosaik pada Produk Rumah Tangga Sebagai Peluang Usaha Baru Bagi Masyarakat Terdampak Pandemi Covid-19
Authors: Ariani Ariani , Novia Rizali Awang Eka , Adisurya Susy Irma , Nugrahadi Gihon
Published: September 2021

Terpuruknya kondisi ekonomi di Indonesia akibat pandemi covid-19 telah berdampak pada semua lapisan masyarakat. Berbagai upaya dilakukan untuk memberdayakan masyarakat, salah satunya melalui kegiatan Pengabdian kepada Masyarakat (PkM). Tema yang diangkat dalam kegiatan kali ini adalah pengaplikasian desain mosaik pada produk rumah tangga sebagai peluang usaha baru bagi masyarakat terdampak pandemi Covid-19, dengan sasaran masyarakat yang bekerja sebagai pengemudi ojek, tukang las, dan pekerja bangunan. Kegiatan ini bertujuan memberikan pengetahuan dan keterampilan tentang pengaplikasian mosaik dari pecahan kaca dan keramik yang dikombinasikan dengan kayu bekas peti kemas menjadi produk nampan. Metode eksperimen dilakukan pada tahap persiapan, dilanjutkan dengan metode participatory action research dan pendampingan pada pelaksanaan pelatihan. Melalui pelatihan ini, para peserta menguasai keterampilan dalam membuat nampan kayu dan memiliki pemahaman estetika dalam menyusun pecahan kaca dan keramik menjadi mosaik. Hasil PkM berupa produk nampan yang
fungsional dan bernilai estetis diharapkan dapat membuka peluang usaha baru bagi para peserta.
Peningkatan Hasil Belajar Qur’an Hadist Melalui Model Pembelajaran Kooperatif Tipe Talking Stick Pada Siswa MTs Al-Huda Kota Gorontalo Tahun pelajaran 2019/2020
Authors: Hulawa Nurliyan
Published: September 2021

Tujuan dari penelitian adalah untuk meningkatkan hasil belajar peserta didik
kelas IX MTS Al-Huda Kota Gorontalo pada mata pelajaran Qur’an Hadist. Penelitian yang dilakukan menggunakan penelitian tindakan kelas dengan sujek penelitian siswa kelas IX MTS Al-Huda Kota Gorontalo. Hasil dari penelitian ini penggunaan model pembelajaran kooperatif tipe talking stick dapat meningkatkan kualitas pembelajaran, baik menyangkut kegiatan guru, aktivitas peserta didik dalam pembelajaran, serta berdampak pada peningkatan hasil belajar peserta didik kelas IX MTS Al-Huda Kota Gorontalo. Hal ini dapat dilihat pada hasil yang dicapai berikut ini : a) Aktivitas guru mengalami peningkatan, dari siklus I sebesar 76.92% yang terlaksana meningkat pada siklus II sebesar 100% yang terlaksana. b) Aktivitas peserta didik mengalami peningkatan, dari siklus I sebesar 54,54% yang tuntas meningkat pada siklus II sebesar 100% yang tuntas. c) Hasil belajar peserta didik mengalami peningkatan, dari siklus I sebesar 71,75% yang tuntas meningkat pada siklus II sebesar 100% yang tuntas
Meningkatkan Kompetensi Profesional Guru Melalui Kegiatan Supervisi Akademik Pada MA Al-Mubarak Marisa
Authors: Ahmad Ismiati
Published: September 2021

Tujuan dari penelitian ini adalah untuk mengetahui peningkatan kompetensi guru melalui kegiatan Supervisi di MA Al-Mubarak Marisa Kabupaten Pohuwato. Hal ini dapat dibuktikan dengan melalui hasil penilaian pelaksanaan pembelajaran pada siklus I mencapai nilai rata-rata 71,35 termasuk dalam kategori baik, kemudian pada siklus II mencapai nilai rata-rata 83,70 termasuk dalam kategori baik. Dengan demikian terjadi peningkatan pelaksanaan pembelajaran sebesar 12,35 %. Guru MA Al-Mubarak Marisa Kabupaten Pohuwato setelah disupervisi melalui kunjungan kelas pra pembelajran yaitu kemampuan menyusun perencanaan pembelajaran yang sekaligus dapat mengalami peningkatan kemampuan melaksanakan pembelajaran. Peningkatan kemampuan guru tersebut dapat dibuktikan dari hasil penilaian pra pembelajaran pra siklus menunjukkan
rata-rata 68,82 dan pada siklus I meningkat sebesar 11,96 % dengan nilai rata-rata 80,78, kemudian pada siklus II meningkat lagi sebesar 10,38 % menjadi 91,17 dengan kategori sangat baik. Peningkatan kemampuan guru dalam pra pembelajaran/perencanaan pembelajaran tersebut sekaligus diikuti dengan peningkatan kemampuan guru dalam melaksanakan pembelajaran pada siklus I mencapai nilai sebesar 71,35 dan pada siklus II mencapai nilai rata-rata sebesar 83,70, maka terjadi peningkatan sebesar 12,35 %. Dengan demikain dapat disimpulkan bahwa melalui kegiatan Supervisi dengan kunjungan kelas dan meningkatakan profesionalisme guru dalam melaksanakan pra
pembelajaran/perencanaan pembelajaran dan dapat mengingkatkan kemampuan
melaksanakan pembelajaran di MA Al-Mubarak Marisa Kabupaten Pohuwato.
Upaya Meningkatkan Kinerja Guru Melalui Supervisi Akademik Kepala Sekolah Di SMK Negeri 2 Wonosari
Authors: Supoyo Supoyo
Published: September 2021

Kemampuan guru dalam menguasai bahan pelajaran pada umumnya sangat
menghawatirkan karena dari sampel guru yang diminta menunjukkan kemampuan menguasai bahan pelajaran 70% yang kurang menguasai bahan pelajaran, sedangkan hanya 30% yang menguasai bahan pelajaran. Kondisi seperti itu diperparah dengan kurang optimalnya fungsi kepengawasan Kepala Sekolah. Bila selama ini banyak pendapat menyatakan profesionalisme guru di Indonesia relatif rendah atau kurang memadai, hal itu merupakan akibat dari kurangnya kepengawasan kepala sekolah. Tujuan dari penelitian tindakan sekolah (PTS) ini adalah untuk mengetahui sejauh mana pembinaan kepala sekolah melalui supervisi akademik untuk meningkatkan kinerja guru dalam pengembangan evaluasi hasil belajar. Dalam penelitian tindakan sekolah (PTS) ini dilakukan dalam 3 siklus, dari hasil tindakan yang dilakukan terbukti dapat meningkatkan kinerja guru dengan mencapai standar ideal. Dari 41,18 % pada siklus I, dapat meningkat menjadi 70,59 % pada siklus II, dan siklus ke III 76,47 %. Hasil penelitian tindakan ini menunjukkan bahwa pembinaan melalui supervisi akademis kepala sekolah dapat meningkatkan kinerja guru dalam pengembangan evaluasi hasil belajar dengan ketuntasan mencapai 100 %.