bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGY OF "SMART SPECIALIZATION" OF THE REGIONS AS A FACTOR OF INNOVATIVE DEVELOPMENT
Authors:   Филиал Дагестанского государственного университета в г. Дербенте, Дербент, Россия, Казиахмед Тагирович Тагиров , Алина Владиславовна Глущенко ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Евгений Александрович Довгань ,   Волгодонский филиал Ростовского юридического института МВД России, Волгодонск, Россия
Published: April 2023

The article analyzes the modern mechanisms of regional innovative development. Based on the main provisions of the implementation of the cluster innovation policy, the authors put forward the assumption that the current period of economic transformation should switch to the strategy of "smart specialization", as this will combine the most effective methods of regional innovation development.
FEATURES OF DIGITAL INTERACTION IN THE ECOSYSTEM OF THE POLITICAL SPACE
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Екатерина Александровна Попова , Златаслава Сергеевна Мартемьянова ,   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия
Published: April 2023

The article reveals the features of digital interaction in the ecosystem of the political space. The influence of digital technologies on interaction in the political space is being studied. The role of artificial intelligence in digital interaction is explored. Based on the study of the features of digital interaction in the ecosystem of the political space, the problems of digital political interaction were identified.
CONCEPTUALITY OF DONBASS: FRAMES OF IDEOLOGICAL AND POLITICAL CONTENT AND COGNITIVE OF DEVELOPMENT STRATEGIES
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Андрей Васильевич Тупаев , Роман Александрович Пупыкин ,   Южный федеральный университет, Ростов-на-Дону, Россия
Published: April 2023

The current geopolitical turbulence, in which our country is located, requires comprehension of several key topics and concepts that are used as the basis for the formation for the formation of Russian-Ukrainian relations, one of such complex concepts is the Donbass. Based on the totality of the theory of political conceptology, cognitive strategies and frames, the article analyzes the specifics and vision of Donbass, identifies groups of the most relevant submissions about the historical features and the current state of the concept of Donbass. The authors come to the conclusion that it is necessary to dive deeper into the philosophical and political discourse of the key ideas and values of the modern confrontation.
SOCIOCULTURAL DIFFERENTIATION OF RUSSIAN YOUTH: THEORETICAL AND METHODOLOGICAL GROUNDS
Authors:   Севастопольский государственный университет, Севастополь, Россия, Владимир Викентьевич Ковров , Иван Михайлович Вакула ,   Ростовский юридический институт МВД России, Ростов-на-Дону, Россия, Наталья Халиловна Гафиатулина ,   Южный федеральный университет, Ростов-на-Дону, Россия
Published: April 2023

The article attempts to analyze the theoretical and methodological foundations of stratification in relation to the socio-cultural differentiation of Russian youth. The study is based on G. Spencer's theory of differentiation and P. Sorokin's classical theory of stratification. Specific criteria for the differentiation of youth as a social group are considered. The authors come to the conclusion that the Russian youth is more differentiated than integrated, because the differentiating factors of youth in Russian society are much stronger than the integrating ones.
INTERETHNIC RELATIONS IN MODERN DAGESTAN SOCIETY: ASSESSMENT AND PROSPECTS
Authors:   Дагестанский федеральный исследовательский центр Российской академии наук, Махачкала, Россия, Мадина Магомедкамиловна Шахбанова
Published: April 2023

The state of the interethnic sphere and the processes taking place within it are indicators of measuring the socio-economic, political, spiritual, ideological picture of society as a whole. In this perspective, it is important to analyze the degree of influence of internal and external factors on the interethnic area, the unresolved problems that are relevant to the population, which can play a destructive function and destabilize society. The author's hypothesis about the fallacy of the opinion that economically developed states can not be afraid of conflicts on their territory (because it is impossible to ensure full ethnic equality and equal access to the material benefits of all the peoples who live in it) is confirmed by the results of the study: the interviewed Dagestani youth sees the nature of conflicts "in human nature, therefore conflicts are inevitable," although other reasons can provoke confrontation of different nature – territorial disputes and lack of mutual understanding between peoples. At the same time, Dagestani youth in general positively assesses the interethnic situation with the argumentation of the existence of "favorable relations between represent-atives of different peoples" and the absence of interethnic confrontation. A negative assessment of the inter-ethnic situation in the territory of their residence is characteristic of a significantly smaller part of the young generation of Dagestanis surveyed, and here it is possible to distinguish representatives of ethnic formations who are in a state of apparently unexpressed ethnic conflict with a number of living peoples.
INNOVATIVE DEVELOPMENT MANAGEMENT OF INTERNATIONAL ORGANIZATIONS IN THE DIGITAL ECONOMY: OPPORTUNITIES AND LIMITATIONS
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Елена Иосифовна Лазарева , Максим Константинович Ноздричев ,   Южный федеральный университет, Ростов-на-Дону, Россия
Published: April 2023

he relevance of the study is determined by the increasing importance in the digital economy of managerial decisions on the innovative development of international organizations. Under the conditions of digital transformation of the economy, the active development of information technology and its close integration into the activities of economic entities appropriate development of innovation management is important. The purpose of the study is to systematize the opportunities and limitations of the implementation of this type of management measures for organizations operating in international markets, characterized by different levels of business processes digitalization. The article substantiates in detail the theses on systematization of opportunities and limitations of innovation management in an international organization, identifies the root causes of their emergence in the process of implementation of innovation projects. It is demonstrated that the results of the study can be applied in the practice of innovation management.
FUNDING SCIENTIFIC RESEARCH IN THE RUSSIAN FEDERATION
Authors:   Московский государственный институт международных отношений МИД России, Москва, Россия, Екатерина Игоревна Шумская
Published: April 2023

Amid the increasing role of science, one of the priories of public administration is rethinking target areas of scientific funding. The concept of attracting investments into interdisciplinary scientific research is sought after in order to increase the efficiency of the funds allocated for funding. Introduction of changes in the current strategic documents of scientific and technological development of the Russian Federation is aimed at developing a unified approach to interdisciplinarity support and is expected to improve the competitiveness of Russian science. The historical and systematic approaches, comparative analysis and content analysis were used in the study, as well as data from Russian Federal State Statistics Service, the Ministry of Science and Higher Education of the Russian Federation and the Organization for Economic Cooperation and Development.
TRANSFORMATION OF TRADITIONAL MODELS OF REGIONAL DEVELOPMENT IN ORDER TO ENSURE THE SUSTAINABILITY OF THE REGION, TAKING INTO ACCOUNT THE ESG PRINCIPLES
Authors:   Северо-Осетинский государственный университет имени К. Л. Хетагурова, Владикавказ, Россия, Кристина Асланбековна Калицева
Published: April 2023

In the current conditions, when the trends of globalization are being replaced by the trends of regionalization and glocalization, and the idea of globalization is increasingly being criticized in the international economic space, the urgency on the part of federal and regional authorities to study issues related to the transition to a sustainable development model is becoming more acute. The implementation of the principles of sustainable development and the need to take into account the basic provisions of the ESG strategy for regional development is now becoming for all regional socio-economic subsystems not just following current trends, but an objective necessity that allows overcoming the inertial nature of the development of both regional systems themselves and their individual components, increasing innovation activity in the region and making it more investment-oriented attractive. All these tasks are becoming more and more urgent for Russian regions due to the need to function in new economic conditions associated not only with the structural restructuring of both the national and global economy, but also the need to fulfill their economic, social and environmental tasks in these conditions in order to improve the quality of life of their population.
PRODUÇÃO E A COMERCIALIZAÇÃO DO COMPLEXO SOJA NO BRASIL: UMA ANÁLISE DAS EXPORTAÇÕES ENTRE 2010 E 2021
Authors: Vidal Gleiciane Munhoz , Rosa Samanda Silva da
Published: April 2023

Nos últimos anos, um grande esforço de exportação tem sido feito no Brasil com o objetivo principal de reduzir a dependência externa do país em relação a empréstimos e investimentos estrangeiros diretos. Nesse contexto, os setores exportadores dinâmicos da economia brasileira, como o complexo soja, desempenham um papel muito importante. O objetivo deste trabalho é analisar especificamente a tendência de exportação do complexo soja grão, farinha e óleo de soja no período de 2010 a 2021. Para isso, utilizamos o modelo de comércio internacional Constant-Market-Share, o que tornou isso possível. O crescimento das exportações pode ser dividido em três efeitos: o crescimento do comércio mundial, o destino das exportações e a competitividade. Aplicando a metodologia, verificou-se que o efeito crescimento do comércio mundial foi o que mais contribuiu para o aumento da exportação de produtos do complexo soja para o Brasil. No entanto, a competitividade também teve impacto positivo apenas na soja. Por outro lado, o efeito destino das exportações associado ao mercado externo do país foi negativo, o que contribuiu para a queda nas exportações de farelo e óleo de soja.
Successful management of renal abscess secondary to diabetes mellitus with surgical treatment and hyperbaric oxygen therapy
Authors:   Department of Urology, Koto Hospital, Koto-ku, Tokyo, Japan, Yanagida Kazuki ,   Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan, Watanabe Daisuke ,   Department of Urology, Koto Hospital, Koto-ku, Tokyo, Japan,   Department of Palliative Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, Yoshida Takahiro ,   Department of Urology, Koto Hospital, Koto-ku, Tokyo, Japan,   Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan, Nakagawa Tohru ,   Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan, Mizushima Akio ,   Department of Palliative Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo, Japan, Miura Kunihisa ,   Department of Emergency Medicine, Tokyo Hikifune Hospital, Sumida-ku, Tokyo, Japan
Published: April 2023

Renal abscess (RA) is a collection of infective fluid in or around the renal parenchyma. It typically occurs in immunocompromised patients including those with diabetes mellitus (DM), poor nutritional status, or steroid administration. We herein report a case of RA associated with DM in which hyperbaric oxygen (HBO2) therapy greatly contributed to the resolution of this disease. The patient was an 85-year-old man with poorly controlled type 2 DM. Contrast-enhanced computed tomography for postoperative follow-up of appendiceal cancer showed a mass lesion with poor contrast enhancement extending from the upper pole of the left kidney to the dorsal side. Therefore, a diagnosis of RA was established. The lesion was percutaneously punctured and a drainage tube was placed. Antibiotics following sensitivity testing was administered. The catheter was removed six days after its placement. However, pus discharge continued from the catheter removal site, with persistent redness around the wound. Therefore, lumbotomy incision for abscess drainage was performed on the 49th day. However, the pus discharge persisted, and we decided to perform HBO2 therapy, expecting decreases in bacterial proliferation, reduction in local edema, and improvement of host defense. HBO2 therapy for 90 minutes at two atmosphere absolute was performed 10 times. The amount of pus discharge decreased and redness improved from the fifth day after HBO2 therapy. One month after starting HBO2 therapy, the wound was closed and pus discharge resolved completely. Four years have passed since the HBO2 therapy, and there have been no symptomatic or imaging relapses of RA.
Innovación Educativa en Contexto Amazónico: Una Apuesta Educativa hacia la Educación Virtual en la Universidad de la Amazonia
Authors: Váquiro – Plazas Yeison Andrés , Castro – Lozada Jaime Andrés , Jaramillo – Morales César Omar , Váquiro – Plazas Díber Albeiro
Published: April 2023

Se presentan los resultados del Estudio de Factibilidad e Investigación de Mercados para la creación de la Maestría en Innovación Educativa modalidad virtual en la Universidad de la Amazonia. Aplicando un muestreo probabilístico y los instrumentos pertinentes, se capturó el nivel de percepción y aceptación en la muestra seleccionada. El objetivo del estudio fue identificar la demanda potencial existente. Dicho estudio fue de carácter descriptivo de corte transversal, desarrollado bajo el método mixto. Los resultados arrojaron una alta aceptación por parte de la población encuestada y de acuerdo con las necesidades identificadas desde el territorio amazónico.
Delincuencia juvenil reflexiones preliminares de una problemática social en auge
Authors: Hernández Álvarez Yesid
Published: April 2023

El presente artículo tiene como objetivo realizar un acercamiento teórico de orden reflexivo en torno a la problemática de la delincuencia juvenil en Colombia, tema coyuntural y en alarmante aumento. La metodología utilizada fue de tipo cualitativo, con un enfoque documental, en el que se pretendió analizar los referentes teóricos consultados y los productos de investigaciones sobre la temática. Los resultados, una vez analizada la información obtenida, son interesantes en la medida en que se reflexionan en relación con el contexto, en torno al incremento desmedido de la problemática, rebasando ampliamente los alcances de las políticas del Estado. Lo que invita a reflexionar seriamente sobre políticas públicas y paradigmas de la educación, de crianza, sobre formación en valores y sobre el entorno por demás nocivo en el que se desarrollan niños, niñas y jóvenes, de los medios de comunicación y demás componentes asociados del entorno, que influyen y propician la conflictividad social y los factores delincuenciales que afectan a la juventud.
Reflexiones en torno a la violencia hacia la mujer
Authors: Castro Jiménez Fidel
Published: April 2023

El presente trabajo girará en torno a la violencia de género como problemática de salud pública de interés particular para los estudiosos de la Psicología, las Ciencias Sociales y profesionales de otras disciplinas científicas. La importancia de esta reflexión radica en el conocimiento de las dinámicas y las repercusiones que se presentan tanto en las víctimas como en los victimarios, en aspectos psicológicos, sociales, culturales, históricos, jurídicos, económicos, laborales, criminalísticas, entre otros aspectos. De ahí, que la agresión hacia la mujer en el contexto familiar despierte interés para la ciencia en los últimos treinta años, a pesar de ser un fenómeno psicosocial tan antiguo como la misma humanidad. En ese orden de ideas, el desarrollo del capítulo plantea una reflexión en torno a algunos componentes socio-históricos relevantes, denota la conceptualización que se ha elaborado en torno a lo que se debe entender como violencia de género, así como también se elabora un planteamiento teórico de esta problemática abordando las diferentes posturas explicativas que permitan el entendimiento del fenómeno mismo. Además, se incluirán importantes análisis estadísticos emanados tanto del informe Forensis (2011) del Instituto Nacional de Medicina Legal y Ciencias Forenses como de la Encuesta Nacional de Salud (2007). De la misma forma, se propone una revisión del Marco Jurídico que transversaliza la violencia de Género. El trabajo pretende dar una revisión al tema central con una mirada general desde la Psicología, pero haciendo énfasis en la Psicología Jurídica y Forense.
Editorial: The new regulatory frontier and the impact on governance and risk control
Authors: Venuti Marco
Published: April 2023

It is an honour and pleasure on behalf of the editorial team to present the first issue of the journal Risk Governance and Control: Financial Markets & Institutions in 2023.
Risk of stillbirth after a previous caesarean delivery: A Swedish nationwide cohort study
Authors: Y Sukainah Al Khalaf , Heazell Alexander , Kublickas Marius , Kublickiene Karolina , Khashan Ali
Published: April 2023

Objectives To investigate the risk of stillbirth in relation
to; 1) a previous CD compared to those following a vaginal birth (VB);
and 2) vaginal birth after caesarean (VBAC) compared to a repeat CD.
Design Population-based cohort study. Setting The
Swedish Medical Birth registry Population Women with their
first and second singletons between 1982 and 2012. Methods
Multivariable logistic regression models were performed to estimate
adjusted odds ratios (aOR) and 95% confidence intervals (CI) of the
association between CD in the first pregnancy and stillbirth in the
second pregnancy and the association between VBAC and stillbirth.
Sub-group analyses were performed by types of CD and timing of
stillbirth (antepartum and intrapartum). Main outcome measures
Stillbirth (antepartum and intrapartum fetal death). Results Of
the 1,771,700 singleton births from 885,850 women,117,114 (13.2%) women
had a CD in the first pregnancy, and 51,755 had VBAC in the second
pregnancy. We found a 37% increased odds of stillbirth (aOR:1.37
[95% CI, 1.23–1.52]) in women with a previous CD compared to VB.
The odds of intrapartum stillbirth was higher in previous pre-labour CD
group (aOR:2.72 [95% CI, 1.51–4.91]) than the previous in-labour
CD group (aOR:1.35 [95% CI, 0.76–2.40,]), although not
statistically significant in the latter case. No increased odds was
found for intrapartum stillbirth in women who had VBAC (aOR:0.99 [95%
CI, 0.48–2.06]) compared to women who had a repeat CD, whereas women
with antepartum stillbirth were more likely to have a VBAC (aOR:4.49
[95% CI, 3.55–5.67]). Conclusions This study confirms
that a CD is associated with an increased risk of subsequent stillbirth,
with a greater risk among pre-labour CD. This association is not solely
mediated by increases in intrapartum asphyxia, uterine rupture or
attempted VBAC. Further research is needed to understand this
association, but these findings might help health care providers to
reach optimal decisions regarding mode of birth, particularly when CD is
unnecessary.
Successful Treatment of Massive Intractable Pericardial Effusion with Tocilizumab in a Child Undergone Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Li Yue , Wang Xiaodong , Zhou Xiaohui , Yu Uet , Liu Sixi
Published: April 2023

A 4-year-old child with β-thalassemia major underwent allogeneic
hematopoietic stem cell transplantation (HSCT) on August 30, 2022 from a
male haploidentical donor. He developed massive pericardial effusion
(PE) secondary to a pulmonary infection. Methylprednisolone, tacrolimus
discontinued, and pericardiocentesis were all ineffective. Since the
interleukin-6 (IL-6) level in the PE was markedly increased
(1868.58pg/ml), a total of two doses of tocilizumab was administered
intravenously at a dosage of 5mg/kg every 2 weeks. PE remarkably reduced
and completely resolved within 8 days. No recurrence of PE was observed
in the follow up visits. Our results suggest that tocilizumab can be
considered as a treatment of choice in massive PE after HSCT.
A ZnO/PVA/CHI Composite Electrode for Rechargeable Zinc-air Battery
Authors: Bao Xinjun , Zhang Zejie , Zhou Liang , He Bin , Hou Jiwei , Zhang Zhuo , Zhou Hengshu , Zhou Debi
Published: April 2023

ZnO/PVA/CHI composite electrode with internal pore structure has been
successfully prepared by cross-linking polymerization of polyvinyl
alcohol (PVA) and chitosan (CHI). The resulting composite electrode
exhibits a maximum anode dissolution current of 0.34A, 4.86 times higher
than that of the pure ZnO electrode (0.07A).More importantly, the Rct of
the composite electrode is 1.01Ω•cm2 for the composite electrode, which
is lower than that of pure ZnO electrode (2.805Ω•cm2), attesting that
the composite electrode possess a more favorable reaction rate.
Moreover, the rechargeable battery assembled with composite electrode
demonstrates a great improvement in charge/discharge efficiency and
cycle stability. It remains over 80% of capacity retention even after
100 cycles, while that of pure electrode can only maintain this level
less than 40 cycles. This proposed composting strategy herein may pay a
way for the exploration of novel zinc anode for rechargeable zinc-air
batteries with superior electrochemical performance.
Revisiting yield in terms of phloem transport to grains suggests phloem sap movement might be homeostatic in wheat
Authors: Tcherkez Guillaume , Holloway-Phillips Meisha , Lothier Jeremy , Limami Anis , Ball Marilyn
Published: April 2023

Phloem sap transport, velocity and allocation have been proposed to play
a role in physiological limitations of crop yield, along with
photosynthetic activity or water use efficiency. Although there is clear
evidence that carbon allocation to grains effectively drives yield in
cereals like wheat (as reflected by the harvest index), the influence of
phloem transport rate and velocity is less clear. Here, we took
advantage of previously published data on yield, respiration, carbon
isotope composition, nitrogen content and water consumption in winter
wheat cultivars grown across several sites with or without irrigation,
to express grain production in terms of phloem sucrose transport and
compare with xylem water transport. Our results suggest that phloem
sucrose transport rate follows the same relationship with phloem N
transport regardless of irrigation conditions and cultivars, and seems
to depend mostly on grain weight (i.e. mg per grain). When compared to
xylem sap water movement, phloem sap velocity (in m s
) was 5.8 to 7.7 times lower. Depending on the
assumption made for phloem sap sucrose concentration, either phloem sap
velocity or its proportionality coefficient to xylem velocity change
little with environmental conditions. Taken as a whole, phloem transport
from leaves to grains seems to be homeostatic within a narrow range of
values and following relationships with other plant physiological
parameters across cultivars and conditions. This suggests that phloem
transport per se is not a limitation for yield in wheat but rather, is
controlled to sustain grain filling.
Rice OsGATA16 is a positive regulator for chlorophyll biosynthesis and chloroplast development
Authors: Paek Nam-Chon , Lim Chaemyeong , Kim Youngoh , Shim Yejin , Cho Sung-Hwan , Yang Tae-Jin , Song Young Hun , Kang Kiyoon
Published: April 2023

Chloroplasts are essential organelles in plants that contain
chlorophylls and facilitate photosynthesis for growth and development.
As photosynthetic efficiency significantly impacts crop productivity,
understanding the regulatory mechanisms of chloroplast development has
been crucial in increasing grain and biomass production. This study
demonstrates the involvement of OsGATA16, an ortholog of
Arabidopsis GATA, NITRATE INDUCIBLE, CARBON-METABOLISM INVOLVED (
GNC), and GNC-LIKE/CYTOKININ-RESPONSIVE GATA FACTOR 1 (
GNL/CGA1), in chlorophyll biosynthesis and chloroplast
development in rice ( Oryza sativa). The osgata16-1
knockdown mutants produced pale-green leaves, while
OsGATA16-overexpressed plants ( OsGATA16-OE1) generated
dark-green leaves, compared to their parental japonica rice.
Reverse transcription and quantitative PCR analysis revealed
downregulation of genes related to chloroplast division, chlorophyll
biosynthesis, and photosynthesis in the leaves of osgata16-1 and
upregulation in those of OsGATA16-OE1. Additionally, in
vivo binding assays showed that OsGATA16 directly binds to the promoter
regions of OsHEMA, OsCHLH, OsPORA, OsPORB,
and OsFtsZ, and upregulates their expression. These findings
indicate that OsGATA16 serves as a positive regulator controlling
chlorophyll biosynthesis and chloroplast development in rice.
Controller Synthesis against Omega-Regular Specifications: A Funnel-based Control Approach
Authors: Jagtap Pushpak , Dimarogonas Dimos
Published: April 2023

The paper focuses on the problem of formal synthesis of controllers for
control-affine nonlinear systems against complex properties. Our goal is
to design a closed-form control policy that guarantees the satisfaction
of complex properties that are expressed using ( ω)-regular
languages and equivalently recognized by Non-deterministic Büchi
Automata (NBA). We propose leveraging a funnel-based control approach to
provide a closed-form solution to the problem. Our approach decomposes
the specification represented by NBA into a sequence of reachability
problems which we solve using a funnel-based control approach.
Controllers associated with each reachability problem are then combined
to design a hybrid control policy enforcing the desired (
ω)-regular property. We demonstrate the effectiveness of the
proposed results on room temperature control and mobile robot motion
control case studies.
New insights of active constituents from herbs and nutraceuticals and their mechanisms in obesity-induced insulin resistance
Authors: Lin Song-Xia , Wu Chao , Li Xiao-Yi , Wang Ya-Li , Lang Deng-Qin , Shen Chun-Yan
Published: April 2023

Insulin resistance (IR) is a main etiology of various metabolic diseases
such as type 2 diabetes mellitus (T2DM), hypertension, hyperlipidemia
and coronary heart disease. IR is a multi-factorial etiology disease
regulated by various mechanisms. Obesity, a significant public health
problem worldwide, is considered as a high-risk factor to induce IR and
T2DM. Thus, inhibiting obesity-induced IR is one of the key therapeutic
strategies to improve T2DM. Natural products from herbs and
nutraceuticals have shown promising efficacy on obesity-induced IR and
T2DM owing to its multi-component and multi-target characteristics.
However, the active constituents and the action mechanisms are still not
yet well elucidated. In this review, the natural constituents with
protective capacities against IR were summarized. The active
constituents include crude extracts such as polyphenols, saponins,
alkaloids, terpenoids, phenylpropanoids, as well as monomeric compounds
such as curcumin, berberine, capsaicin, naringenin, quercetin, betaine
and isoliquiritigenin. The action mechanisms of these active
constituents could be mainly divided into 4 categories: ameliorating
metabolic abnormality, inhibiting inflammation, reversing gut microbiota
dysbiosis, regulating micro RNAs (miRNAs). Their precise roles in
regulating PI3K/AKT, AMPK, PPARs, SIRT1 and NF-κB pathways, brown
adipose tissue activity and white adipose tissue browning, NLRP3
inflammasome activity, gut microbiota structure and composition and
miRNA expression were discussed. The sources, chemical structures,
experimental models, pharmacological effects and action targets of these
active constituents were also summarized. This review provides new
active constituents, therapeutic targets and reasoning for the clinical
application of herbs and nutraceuticals in the treatment of IR and T2DM.
Fatal outcome of Severe Fever With Thrombocytopaenia Syndrome (SFTS) and Severe and Critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β
Authors: Lee Keun Hwa , Kang Su Yeon , Yoo Jeong Rae , Park Yejin , Kim So-Hee , Heo Sang Taek , Park Seong Hyeon , Kim Misun , Kim Tae-Jin , Oh Songhyeok , Lee Moo-Seung , Kim Jung Mogg , Cho Nam-Hyuk , Lee Kyung-Mi
Published: April 2023

Severe fever with thrombocytopaenia syndrome virus (SFTSV) and Severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the
hyperproduction of inflammatory cytokines, which have pathological
effects in patient including severe or fatal cytokine storms. To
characterize the effect of SFTSV and SARS-CoV-2 infection on the
production of cytokines in SFTS and COVID-19 patients, we performed an
analysis of cytokines in SFTS and COVID-19 patients and also
investigated the role of IL-10 in vitro studies: LPS-induced
THP-1-derived macrophages, SFTSV infection of THP-1 cells, and
SARS-CoV-2 infection of THP-1 cells. In this study, we found that levels
of both IL-10 and IL-6 were significantly elevated, the level of TGF-β
was significantly decreased and IL-10 was elevated earlier than IL-6 in
severe and critical COVID-19 and fatal SFTS patients, and inhibition of
IL-10 signalling decreased the production of IL-6 and elevated that of
TGF-β. Therefore, the hyperproduction of IL-10 and IL-6 and the low
production of TGF-β have been linked to cytokine storm-induced mortality
in fatal SFTS and severe and critically ill COVID-19 patients and that
IL-10 can play an important role in the host immune response to severe
and critical SARS-CoV-2 and fatal SFTSV infection.
Omicron breakthrough infections in wild-type SARS-CoV-2 vaccinees elicit high levels of neutralizing antibodies against pangolin coronavirus GX_P2V
Authors: Song Lihua , Lu Shanshan , Luo Shengdong , Bai Bingke , Fan Zhenping , Hong Bixia , Xu Wen , Ma Hongbin , Chen Wei-Wei , Fan Huahao , Tong Yigang
Published: April 2023

Omicron BF.7 became the predominant SARS-CoV-2 variant in Beijing after
the adjustment of COVID-19 response strategies in December 2022. The
ability of antibodies elicited by BF.7 infection to cross-react with
SARS-CoV-2-like viruses is unknown. This study aimed to investigate the
cross-reactive neutralizing antibodies against SARS-CoV-2-related
pangolin coronavirus GX_P2V in sera from vaccinated and/or SARS-CoV-2
infected individuals. All vaccinated individuals who recovered from
Omicron BF.7 breakthrough infections exhibited substantially higher
levels of neutralizing antibodies against GX_P2V among collected
subject populations (geometric mean titer [GMT] = 362). Uninfected
individuals who received four-mixed-dose vaccines also demonstrated
higher levels of neutralizing antibodies (GMT = 44) against GX_P2V than
those who received two- or three-dose vaccines and those who recovered
from wild type SARS-CoV-2. This finding highlights the significance of
prior and hybrid booster vaccinations with wild-type SARS-CoV-2 vaccines
in generating potent cross-protective immunity against future spillovers
of SARS-CoV-2-like viruses.
X-ray characterization of three possible edible oleogelators: Experiment and Theory
Authors: Peyronel Fernanda , Cooney Joseph , Papp-Szabo Erzsebet , Martini Silvana , Pink David
Published: April 2023

Three oleogeletors molecules (Triacontane (TC), Stearic acid (SA), and
Behenyl Lignocerate (BL)) were studied individually, in pairs, or all
together to make an oleogel using triolein as the oil. WAXS, SAXS and
USAXS were used to elucidate the solid structures from angstroms to a
few micrometers. A two-dimensional mapping of atomic positions for each
molecule was carried out to understand the crystalline multilayer
structures formed. We assumed that the molecules were rigidly extended
and that they underwent no significant (hindered) rotations so that the
free energy is determined by the Lennard-Jones interactions of
closely-packed multilayers. TC molecules were predicted to form a tilt
angle of θ ≈ 33°, yielding a SAXS line at q≈ 0.194
Å, in acceptable agreement with the measured q=0.181
Å.For SA crystals θ ≈ 33°
(predicted) yielding a SAXS line at q=0.150 Å
compared to q=0.159 Å (observed). No mixed crystals
were observed for any pair of molecules or when all three were used.
USAXS data showed that SA forms large nanocrystals compared to TC and
BL. All three combinations of molecular pairs showed basic scatterers
smaller or similar to those of individual molecules. The theory
presented here, together with the experimental results, showed why no
mixed crystals are formed from two or all three molecules. Data from the
USAXS region suggested that, when using all three molecules, a more
compact fractal structure was obtained, compared with those if one or
two of the molecules were used.
Impact of E-Learning Management Systems During Covid-19 Pandemic
Authors: Omorogiuwa O , Abdul F. , Ohiagu K.
Published: April 2023

Impact of E-Learning Management Systems During Covid-19 Pandemic *Osaremwinda Omorogiuwa, Abdul Farida & Ohiagu Kingsley Department of Computer Science & Information Technology Igbinedion University Okada, Edo State, Nigeria. *Corresponding Author E-mail: ask4osas@iuokada.edu.ng ABSTRACT The essence of this study is to provide a comprehensive review of the impact of e-learning in universities during the COVID-19 pandemic which led to the closure of schools around the world. In other to continue learning most universities had to adopt the e-learning approach, which made it possible for their students to remotely access lecture materials, attend virtual classrooms at the comfort of their homes with the use of electronic Learning Management Systems (eLMS). This new mode of learning which was abruptly adopted by most universities had its challenges despite its gains during the pandemic. This research is to subjectively analyse the impact of eLMS during Covid 19 pandemic using some software quality attributes such as efficiency, effectiveness, flexibility and usability. To this end, a structured questionnaire was developed using these variables and distributed both physically and electronically to students in three universities in Edo State. An empirical data of 638 students participated from the different universities. The results showed that the ease of use and perceived efficiency positively correlated with facilitating information Technology infrastructure, adaptation, and self-efficacy, which in turn affects the actual use of the e-learning system during the COVID-19 pandemic. Keywords: eLMS, COVID-19 Pandemic, Software Quality, E-learning, Education in pandemic
Evaluation of the Relationship Between Entrepreneurial Orientation and Cultural Values on Performance of Small and Medium-sized Enterprises in Southwest Nigeria
Authors:   1Department of Business Administration, Ekiti State University, Ado-Ekiti, Ekiti State, Nigeria 2Department of Entrepreneurial Studies, Bamidele Olumilua University of Education,  Science and Technology, Ikere Ekiti, Ekiti State, Nigeria  3Department of Management Science, Bamidele Olumilua University of Education,  Science and Technology, Ikere Ekiti, Ekiti State, Nigeria, Ibijoju Taiwo Reuben PhD , Fayigbe, Gbenga Samson , Babatunde Olayinka Funmi
Published: April 2023

This study gave an evaluation of the relationship between entrepreneurial orientation and cultural values on performance of small and medium-sized enterprises (SMEs) in southwest Nigeria. Primary method of data collection was used. Data were collected through the use of structured questionnaire administered randomly on carefully selected sample of 400 owners, managers/supervisors of SMEs who have been in existence for a period of a minimum of five years and above through multi-stage sampling technique. Structural equation modelling (SEM) was used to examine the relationship between entrepreneurial orientation and cultural values on the performance of SMEs in southwest Nigeria. The result indicates that both entrepreneurial orientation and cultural values are strongly related with high level of relationship. This study concluded that managers need to leverage the dimensions of both entrepreneurial orientation such as innovativeness, proactiveness, and risk taking as well as the dimensions of cultural values such as individualism/collectivism, power distance, masculinity/femininity, uncertainty avoidance to achieve optimal business performance. Keywords: Entrepreneurial orientation, small and medium-sized enterprises, performance, dimensions. cultural values
The Historical Analysis of the Spread of FOMWAN and Its Contributions to the Growth of Islam in Ekiti State, Nigeria
Authors:   Department of Arts Education, School of Multidisciplinary Studies,  Bamidele Olumilua University of Education, Science and Technology Ikere-Ekiti, Ekiti State, Nigeria Email: balogun.yisa@bouesti.edu.ng Phone: +2348030790387   ORCID: 0000-0002-0994-5874, Balogun Yisa Olorunda (Ph.D)
Published: April 2023

The Federation of Muslim Women’s Associations in Nigeria (FOMWAN) is a nongovernmental Muslim Women Associations in Nigeria. It is an umbrella body for all Muslim Women organizations throughout the length and breadth of the county. The apex body was formed in Nigeria in 1985 and Ekiti State in 1996. The aims of the study include the acquaintance of the readers with the history of FOMWAN in Nigeria, particularly, Ekiti State and supplementing the exiting literatures on the body. The factors that necessitated the formation of the association in the state ranged from its absence in the state and the need to have a united voice in demanding for their rights from the government. The association is faced with numerous problems such as the challenge of men’s associations and leadership problems. Our findings include lack of interest of many Muslim women to attend the meetings of the organization and low source of income. Data and relevant information were collected from written sources. These include published and unpublished works such as books, journals, magazines, theses, dissertations, reports, circulars, monographs, manuscripts and records of programmes and correspondence, and constitutions that were collected in libraries, internet and personal custodies. Keywords: FOMWNAN, Spread, Contribution, Growth, ISLAM, Ekiti State, Nigeria
Sustainable management of Special Nature Reserves of Public Enterprise "Vojvodinasume"
Authors: Vasic Ivana , Marinkovic Marko , Velojic Miljan , Tubic Bojan
Published: April 2023

Since that 65% of the surface managed by the Public Enterprise (PE)
?Vojvodinasume? are in some degree of protection, protected areas management
is one of the key elements in the company?s business policy. The management
of protected areas, especially in the current circumstances of the evident
climate change effects, has become a challenge for nature protection and
other sectors, and therefore also for PE ?Vojvodinasume?. Protected areas
are drivers of the rural economy and a key element in the development of
rural area strategies. The aim of the work is to present examples of
cooperation with stakeholders from the public, private and civil sectors, on
the planning and implementation of activities that contribute to the
sustainable protected areas management. The activities of PE ?Vojvodinasume?
protected areas management include: sustainable management of resources,
protection of biodiversity, conflict resolution, provision of benefits for
society, and especially for the local community, promotion of natural
values, etc. Sustainable management of protected areas in PE ?Vojvodinasume?
implies multifunctional and long-term management that is adapted to local,
i.e. regional conditions.
Anesthetic Concerns in a Child Presenting with Large Cervical Chordoma- A Case Report
Authors: N Ramakumar
Published: April 2023

Chordomas are rare, low-grade, and slow-growing malignant tumors with an incidence rate of 0.08 in 1,00,000 people. Spinal chordomas can cause back pain, pathological fractures, and myelopathy or radiculopathy due to spinal cord and nerve root compression. Treating these tumors can be challenging owing to their proximity to vital structures and high recurrence rates. We report the anesthesia management of a 10-year-old boy with cervical chordoma posted for laminectomy, and excision was a challenge for airway management.
LEVEL OF INTERLEUKIN-6 IN STABLE COPD PATIENTS USING THE EXHALED BREATH CONDENSATE
Authors: Tentua Vebiyanti
Published: April 2023

ABSTRACT

Chronic obstructive pulmonary disease (COPD) is a chronic systemic inflammatory disease that is associated with high morbidity and mortality rates. Interleukin 6 is a proinflammatory cytokine that can be used as a marker of COPD treatment. We conducted a cross-sectional study involving 83 stable COPD patients at X Jakarta Hospital, mostly male (90,4%) with mean ages was 66,07 years. Patients were interviewed using the CAT and mMRC scoring. Patients also underwent a spirometry and had their condensed breaths collected using a device made of a S-shaped glass tube that was immersed in a thermos filled with ice cubes and collected for ELISA examination. This study result was IL-6 detected in 76 patients (91,56%) with mean level of IL-6 was 0,702 pg/ml ± 0,41 pg/ml. We conclude that IL-6 levels from exhaled breaths of stable COPD patients can be collected using a condensation exhalation device and can be recommended as biomarkers of successful treatment of COPD.

ABSTRAK

Penyakit paru obstruktif kronik (PPOK) merupakan penyakit inflamasi sistemik kronis yang berhubungan dengan angka morbiditas dan mortalitas yang tinggi. Interleukin 6 merupakan sitokin proinflamsi yang dapat digunakan sebagai penanda keberhasilan pengobatan PPOK. Penelitian ini menggunakan design cross sectional dengan 83 sampel pasien PPOK stabil di RS X Jakarta. Pasien diwawancarai menggunakan skor CAT dan mMRC. Pasien juga melakukan pemeriksaan spirometri dan dikumpulkan hembusan napas kondensasinya menggunakan alat yang terbuat dari tabung kaca berbentuk huruf S yang direndam pada termos berisi es batu sehingga hembusan napasnya dapat dikumpulkan untuk kemudian diperiksakan ELISA. Hasil penelitian didapatkan bahwa IL-6 terdeteksi pada 76 pasien (91,56%) dengan kadar IL-6 rata- rata 0,702 pg/ml ± 0,41 pg/ml. Kami menyimpulkan bahwa kadar IL-6 dari hembusan napas pasien PPOK stabil dapat dikumpulkan menggunakan alat hembusan napas kondensasi dan untuk selanjutnya dapat direkomendasikan untuk dijadikan biomarker keberhasilan pengobatan pasien PPOK.
INFEKSI NOROVIRUS DENGAN DERAJAT KEPARAHAN DIARE AKUT PADA BALITA DI SURABAYA
Authors: Rusdi Warda Elmaida , Wicaksono Galih , Farindra Irmawan
Published: April 2023

ABSTRACT

Diarrhea is one of the most common diseases in Indonesian society. In 2010 there were 411 events per 1000 population per year. Toddlers aged 1-4 years have the highest prevalence, which is around 16.7%. Based on data from the Surabaya City Health Office, diarrheal diseases in the city of Surabaya in 2015 were 65,447 cases. Norovirus, an unenveloped single RNA virus from the family Calciviridae, is the second most common cause of acute diarrhea after rotavirus. The purpose of this study was to analyze the relationship between the severity of acute diarrhea and Norovirus infection in children under five in Surabaya. The study was conducted using an observational analytic method, the research sample was taken by incidental sampling as many as 50 research samples with the criteria of patients suffering from acute diarrhea aged 5 years who came and were treated at the Surabaya Public Health Center. Examination of the RT-PCR method on samples was carried out to determine the occurrence of Norovirus infection. The data collected in the bivariate analysis was tested on two related variables or using the Chi Square statistical test. The results showed that the proportion of pediatric patients aged 5 years with acute diarrhea who were positive for Norovirus infection using the RT-PCR examination method was 38 children. Based on the results of the analysis through calculations using the Vesikari score, there is a significant relationship between the severity of diarrhea and Norovirus infection.

ABSTRAK

Diare menjadi salah satu penyakit yang banyak mengenai masyarakat Indonesia. Pada tahun 2010 terdapat 411 kejadian per 1000 penduduk per tahun. Balita usia 1-4 tahun merupakan prevalensi tertinggi yaitu sekitar 16,7%. Berdasarkan data Dinas Kesehatan Kota Surabaya, penyakit diare di Kota Surabaya pada tahun 2015 sebanyak 65.447 kasus. Norovirus, virus RNA tunggal tak berselubung dari family Calciviridae merupakan penyebab terbanyak kedua diare akut setelah Rotavirus. Tujuan penelitian ini adalah menganalisis adanya hubungan derajat keparahan diare akut dengan infeksi Norovirus pada balita di Surabaya. Penelitian dilakukan dengan metode analitik observasional, sampel penelitian diambil secara incidental sampling sebanyak 50 sampel penelitian dengan kriteria pasien yang menderita diare akut usia ≤ 5 tahun yang datang dan dirawat di puskesmas Surabaya. Pemeriksaan metode RT-PCR pada sampel dilakukan untuk menentukan terjadinya infeksi Norovirus. Data yang terkumpul di analisis bivariat, dilakukan uji terhadap dua variabel yang berhubungan atau menggunakan uji statistik Chi Square. Hasil penelitian menunjukkan proporsi pasien anak usia ≤ 5 tahun dengan diare akut yang positif terinfeksi Norovirus dengan metode pemeriksaan RT-PCR adalah sebanyak 38 anak. Berdasarkan hasil analisis melalui perhitungan menggunakan skor Vesikari, terdapat hubungan yang signifikan antara tingkat keparahan diare dengan infeksi Norovirus.
Global dynamic of spatio-temporal fractional order SEIR model
Authors:   Laboratory of Mathematics, Computer Science and Applications, FST Mohammedia, University Hassan II of Casablanca, Bounkaicha C. , Allali K. ,   Laboratory of Mathematics, Computer Science and Applications, FST Mohammedia, University Hassan II of Casablanca, Tabit Y. ,   LRPFG Laboratory, ENCG of Casablanca, University Hassan II, Casablanca, Danane J. ,   Laboratory of Systems, Modelization and Analysis for Decision Support, National School of Applied Sciences, Hassan First University
Published: April 2023

The global analysis of a spatio-temporal fractional order SEIR infection epidemic model is studied and analyzed in this paper. The dynamics of the infection is described by four partial differential equations with a fractional derivative order and with diffusion. The equations of our model describe the evolution of the susceptible, the exposed, the infected and the recovered individuals with taking into account the spatial diffusion for each compartment. At first, we will prove the existence and uniqueness of the solution using the results of the fixed point theorem, and the equilibrium points are established and presented according to R0. Next, the bornitude and the positivity of the solutions of the proposed model are established. Using the Lyapunov direct method it has been proved that the global stability of the each equilibrium depends mainly on the basic reproduction number R0. Finally, numerical simulations are performed to validate the theoretical results.