bluuebunny/crossref_metadata_2025 huggingface dataset:
Which type of feedback—Positive or negative- reinforces decision recall? An EEG study
Authors: Balconi Michela , Angioletti Laura , Allegretta Roberta A.
Published: January 2025

This study examines the impact of positive and negative feedback on recall of past decisions, focusing on behavioral performance and electrophysiological (EEG) responses. Participants completed a decision-making task involving 10 real-life scenarios, each followed by immediate positive or negative feedback. In a recall phase, participants’ accuracy (ACC), errors (ERRs), and response times (RTs) were recorded alongside EEG data to analyze brain activity patterns related to recall. Results indicate that accurately recalled decisions with positive feedback had slower RTs, suggesting an attentional bias toward positive information that could increase cognitive load during memory retrieval. A lack of difference in recall accuracy implies that social stimuli and situational goals may influence the positivity bias. EEG data showed distinct patterns: lower alpha band activity in frontal regions (AF7, AF8) for both correct and incorrect decisions recall, reflecting focused attention and cognitive control. Correctly recalled decisions with negative feedback showed higher delta activity, often linked to aversive processing, while incorrect recalls with negative feedback showed higher beta and gamma activity. A theta band feedback-dependent modulation in electrode activity showed higher values for decisions with negative feedback, suggesting memory suppression. These findings suggest that recalling decisions linked to self-threatening feedback may require greater cognitive effort, as seen in increased beta and gamma activity, which may indicate motivational processing and selective memory suppression. This study provides insights into the neural mechanisms of feedback-based memory recall, showing how feedback valence affects not only behavioral outcomes but also the cognitive and emotional processes involved in decision recall.
The efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopy
Authors: Shan Weifeng , Gao Shuying , Ai Mengting , Lan Haiyan , Duan Gongchen , Dong Xiaoli , Xu Qiaomin , Wu Yini , Wu Jimin
Published: January 2025

Objective

Remimazolam besylate and Ciprofol are newer sedatives used in minor surgeries. Propofol is a classic drug mainly used for short surgeries. This trial was conducted to compare the efficacy and safety of remimazolam besylate, ciprofol, and propofol during hysteroscopic surgeries.

Methods

Patients undergoing hysteroscopy were randomly assigned to receive remimazolam besylate (Group R), ciprofol (Group C), or propofol (Group P). A total of 194 patients were assessed for eligibility. One patient in Group P was excluded because the operation had timed out of 60 min. Patients all in Group R、Group C and Group P received an induction dose of 0.2 mg/kg remimazolam besylate、0.4 mg/kg ciprofol、2.0 mg/kg propofol seperately over 30 s. A corresponding dosage of 1 mg/kg/h、0.6–1.2 mg/kg/h and 3.0–6.0 mg/kg/h was given by continuous intravenous infusion to maintain a BIS of 40–60 till the end of the surgery. The incidence rates of body movement, respiratory depression, and adverse effects were compared among the groups.

Results

The incidence of injection pain was much higher in Group P (64.1%) than that in Group R (3.4%) and Group C (3.2%, both P < 0.001). The onset time was significantly shorter in Group P than that in Group R and Group C (both P < 0.01). The awakening time (MOAA/S score = 3) was longest in Group R, followed by Groups C and Group P (P < 0.01). The time to complete recovery (MOAA/S score = 5) has no significantly difference between Group C and Group P, whereas the onset time was significantly shorter in Group R (P < 0.01). The number of body movements was significantly higher in Group R than that in Group C and Group P (P < 0.01). The incidence of hypotension was significantly lower in Group R than that in Group C and Group P (both P < 0.01). The rate of respiratory inhibition was significantly lower in Group R and Group C than that in Group P (both P < 0.05).

Conclusion

Considering jointly the safety and efficacy, ciprofol seems to be the best choice for sedation.
Anti-inflammatory and antioxidant properties of oleuropein in human keratinocytes characterized by bottom-up proteomics
Authors: Li Huifang , Deng Ni , Yang Jiayi , Zhao Yang , Jin Xiaoxuan , Cai Ang , Seeram Navindra P. , Ma Hang , Li Dongli , Yang Huilan , Liu Chang
Published: January 2025

Oleuropein is a phenolic compound commonly found in cosmetic ingredients including olive leaves and jasmine flowers with various skin-beneficial effects. Here, we evaluated oleuropein’s anti-inflammatory and antioxidant activities in human skin cells. In a cell-based inflammasome model with human monocytes (THP-1 cells), oleuropein (12–200 µM) reduced proinflammatory cytokine interleukin (IL)-6 by 38.8%–45.5%, respectively. Oleuropein (50 and 100 µM) also alleviated oxidative stress in keratinocytes (HaCaT cells) by reducing H2O2-induced cell death by 6.4% and 9.2%, respectively. Additionally, biological evaluations revealed that oleuropein’s antioxidant effects were attributed to its mitigation of reactive oxygen species in HaCaT cells. Furthermore, a multiplexed gene assay identified IL-1β and thioredoxin-interacting proteins as potential molecular targets involved in oleuropein’s protective effects in HaCaT cells. This was supported by findings from several cellular assays showing that oleuropein reduced the level of IL-1β and inhibited the activity of caspase-1/IL-1 converting enzyme, as well as ameliorated pyroptosis in HaCaT cells. Moreover, a bottom-up proteomics study was conducted to explore potential molecular targets and signaling pathways involved in oleuropein’s antioxidant activities. Taken together, findings from this study expand the understanding of oleuropein’s skin protective effects against oxidative and inflammatory stresses, which support that oleuropein is a promising natural cosmeceutical for skincare applications.
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota
Authors: Shen Yunjiao , Gao Yansong , Yang Ge , Zhao Zijian , Zhao Yujuan , Gao Lei , Li Shengyu
Published: January 2025

Objective

Minor ginsenosides have demonstrated promising anticancer effects in previous reports. Total minor ginsenosides (TMG) were obtained through the fermentation of major ginsenosides with Lactiplantibacillus plantarum, and potential anticancer effects of TMGs on the mouse colon cancer cell line CT26.WT, in vitro and in vivo, were investigated.

Materials and Methods

We employed the Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), and Western blot analysis in vitro to explore the anti-proliferative and pro-apoptotic functions of TMG in CT26.WT cells. In vivo, a xenograft model was established by subcutaneously injecting mice with CT26.WT cells and administering a dose of 100 mg/kg/day TMG to the tumor-bearing mice. The level of apoptosis and expression of various proteins in the tumor tissues were detected by immunohistochemistry and Western blot. High-throughput 16S rRNA sequencing was used to determine the alterations in the gut microbiota.

Results

In vitro studies demonstrated that TMG significantly inhibited proliferation and promoted apoptosis in CT26.WT cells. Interestingly, TMG induced apoptosis in CT26.WT cells by affecting the Bax/Bcl-2/caspase-3 pathway. Furthermore, the result of the transplanted tumor model indicated that TMG substantially enhanced the activities of Bax and caspase-3, reduced the activity of Bcl-2, and suppressed the expression of Raf/MEK/ERK protein levels. Fecal analysis revealed that TMG reconstructed the gut microbiota in colorectal cancer-affected mice by augmenting the abundance of the advantageous bacterium Lactobacillus and decreasing the abundance of the harmful bacterium Proteus.

Conclusion

TMG can exhibit potent anti-colorectal cancer effects through diverse apoptotic mechanisms, with their mode of action closely related to the regulation of gut microbiota.
Application of additive manufacturing for the adaptive design of ultrasound phantoms
Authors: Zalka Lukas , Köhrer Johannes , Songsaeng Chatsuda , Homolka Peter , Kollmann Christian , Hummel Johann , Figl Michael
Published: January 2025

Introduction

The image formation process of conventional pulse-echo Ultrasound mainly uses the backscattered amplitude and assumes constant attenuation and speed of sound in the penetrated media. Thus, many commercially available ultrasound imaging phantoms use only a limited choice of materials with simple geometric shapes. Part of today’s research in ultrasound is to gain more information on the acoustic properties of the object imaged. These advanced imaging and reconstruction procedures require more complicated phantom designs that contain different materials with precisely designable acoustic properties for validation and quality assurance (QA).

Methods

To fabricate such phantoms, we produced molds for casting ultrasound phantoms using additive manufacturing. Phantom materials used were based on agar and polyvinyl alcohol. To adapt the speed of sound glycerol was added to the mixtures. As glycerol diffuses out of the phantom material, polluting the surrounding water, we designed a watertight sample holder. The effect of the freeze-thaw cycles (FTCs) on the acoustic properties of the polyvinyl alcohol (PVA)-based phantoms was also investigated. Speed of sound and attenuation were determined for both phantoms materials, and Shore hardness measured for the PVA-based phantoms.

Results

Shore hardness of the PVA phantoms increased by up to 79% of the initial value with increasing number of freeze-thaw cycles, but showed a saturation after 5 FTCs. However, the number of FTCs had only a small effect on the speed of sound and attenuation, as the sound speed increased slightly from 1,530.14 m/s to 1,558.53 m/s, (1.86%) and the attenuation exhibited only an increase of 6.75%. In contrast, differences of around 100 m/s in the speed of sound in the PVA phantoms (from 1,558.53 to 1,662.27 m/s), as well as in the agar-based phantoms (from 1,501.74 to 1,609.36 m/s) could be achieved by adding glycerol, making these materials appropriate candidates for the design and fabrication of US phantoms with defined sections and details with different speed of sound and attenuation. The use of the sample holder showed only an influence of 0.63% on the measured speed of sound.

Discussion

3D printed molds led to an improved manufacturing process as well as a free choice of the shape of the phantoms. A sample holder could prevent contamination of the water with no significant differences in the measured speed of sound.
Study on the stability and accuracy of the new Booster portable cardiopulmonary function meter
Authors: Yun Hezhang , Zhang Wenbo , Yu Chen , Li Qiang , Song Yafeng
Published: January 2025

This study aims to assess the reliability and accuracy of a novel portable cardiopulmonary function meter, “Booster,” developed by our research group, across various exercise intensities and modalities. The study was segmented into reliability and validity assessments. Twenty-two male participants underwent reliability testing, conducting two sequential tests on a treadmill while wearing the Booster to measure VO2 and VE among other parameters at increasing intensities. For validity testing, 64 participants were randomly divided into treadmill and cycle ergometer groups, with tests conducted using both the Booster and the Cortex Metalyzer 3B systems. Overall, the Booster demonstrated high retest reliability for VO2 and VE measurements during treadmill exercises, albeit showing poor consistency during rest and low-intensity exercise phases. Validity testing indicated no significant differences in VO2 and VE measurements between Booster and Cortex Metalyzer 3B across all exercise stages on both treadmill and cycle ergometer, suggesting good correlation. However, discrepancies in measurements between Booster and Cortex Metalyzer 3B were observed during rest and maximal exertion phases. The Booster exhibits commendable reliability and stability during most treadmill exercise phases and shows generally acceptable validity compared to the Cortex Metalyzer 3B system. Nonetheless, potential measurement discrepancies may occur during rest and maximal exertion conditions.
Miniature-inverted-repeat transposable elements contribute to phenotypic variation regulation of rice induced by space environment
Authors: Chen Lishan , Yang Qing , Zhang Yan , Sun Yeqing
Published: January 2025

Introduction

Rice samples exposed to the space environment have generated diverse phenotypic variations. Miniature-inverted-repeat transposable elements (MITEs), often found adjacent to genes, play a significant role in regulating the plant genome. Herein, the contribution of MITEs in regulating space-mutagenic phenotypes was explored.

Methods

The space-mutagenic phenotype changes in the F3 to F5 generations of three space-mutagenic lines from the rice varieties Dongnong423 (DN423) and Dongnong (DN416) were meticulously traced. Rice leaves samples at the heading stage from three space-mutagenic lines were subjected to high coverage whole-genome bisulfite sequencing and whole-genome sequencing. These analyses were conducted to investigate the effects of MITEs related epigenetic and genetic variations on space-mutagenic phenotypes.

Results and discussion

Studies have indicated that MITEs within gene regulatory regions might contribute to the formation and differentiation of space-mutagenic phenotypes. The space environment has been shown to induce the transposable elements insertion polymorphisms of MITEs (MITEs-TIPs), with a notable preference for insertion near genes involved in stress response and phenotype regulation. The space-induced MITEs-TIPs contributed to the formation of space-mutagenic phenotype by modulating the expression of gene near the insertion site. This study underscored the pivotal role of MITEs in modulating plant phenotypic variation induced by the space environment, as well as the transgenerational stability of these phenotypic variants.
Development of KASP markers, SNP fingerprinting and population genetic analysis of Cymbidium ensifolium (L.) Sw. germplasm resources in China
Authors: Shen Baoming , Shen Airong , Tan Yun , Liu Lina , Li Sainan , Tan Zhuming
Published: January 2025

Cymbidium ensifolium (L.) Sw. is a valuable ornamental plant in the genus Cymbidium, family Orchidaceae, with high economic and ecological significance. However, the lack of population genetic information and molecular markers has hindered the development of the sales market and genetic breeding of C. ensifolium despite the abundance of commercial cultivars available. In this study, we aimed to develop a set of single nucleotide polymorphism (SNP) markers to distinguish the main cultivated C. ensifolium cultivars in China and provide technical support for domestic cultivar protection, registration, and market rights protection. A total of 1,280,516 high-quality loci were identified from 10,021,591 SNPs obtained by sequencing 50 C. ensifolium commercial cultivars using double digest restriction site-assisted DNA sequencing technology. A total of 7,599 SNPs were selected for kompetitive allele-specific PCR (KASP) primer design, and 4,360 were successfully designed as KASP markers. Population structure analysis revealed that the 50 commercial cultivars were best divided into four populations, with some correlation between the group distribution and the morphological and geographical characteristics of the germplasm. Using the genotyping results from 28 KASP markers screened from the cultivars, a minimum set of 11 markers was identified that could distinguish 83 C. ensifolium commercial cultivars completely, with the remaining 17 markers serving as extended markers. The average PIC value of the 11 markers was 0.345, which was considered medium polymorphism. DNA fingerprints were constructed for the 83 cultivars on the basis of the 11 KASP markers, providing a new approach for mapping DNA fingerprints in C. ensifolium cultivars with high efficiency, accuracy, and low cost compared with traditional methods.
Identification of a potential homeodomain-like gene governing leaf size and venation architecture in birch
Authors: Bian Xiuyan , Chen Chen , Wang Yang , Qu Chang , Jiang Jing , Sun Yao , Liu Guifeng
Published: January 2025

Leaf vein, an essential part of leaf architecture, plays significant roles in shaping the proper leaf size. To date, the molecular mechanisms governing leaf development including leaf venation patterning remains poorly understood in birch. Here, we performed the genome-wide identification of homeodomain-like (HD-like) superfamily genes using phylogenetic analysis and revealed the functional role of a potential HD-like gene in leaf growth and development using transgenic technology and transcriptomic sequencing. A total of 267 HD-like genes were identified based on Arabidopsis HD-containing transcription factors, which were members of KNOTTED1-like homeobox (KNOX) family, BELL1-like homeobox (BLH) family, Zinc finger-HD (ZHD) family, HD-leucine zipper (HD-Zip) family, Golden2, ARR-B, Psr1 (GARP) family, WUSCHEL-related homeobox (WOX) family, and Myeloblastosis (MYB) and MYB-like family. Further, 41 HD-like genes showing co-expression with marker genes related to leaf vascular tissues exhibited differential expression during primary vein development. Among them, a potential HD-like gene (BpPHD4) of GARP family served as a negative factor in governing leaf size and venation patterning. Compared to non-transgenic plants, BpPHD4 repression transgenic plants showed increased leaf length, leaf width, leaf area, leaf thickness, spongy tissue thickness, stomata number, epidermal cell size, primary vein length, the distance between the secondary veins, and primary vein diameter, which was opposite to those of BpPHD4 overexpression transgenic plants. Meanwhile, reduced expression levels of BpPHD4 could remarkably promote phloem tissue development. Transcriptome analysis of BpPHD4 overexpression transgenic plants showed two candidate genes (Bpev01.c0518.g0018 and Bpev01.c2797.g0002) probably regulated by BpPHD4. To conclude, our findings contribute to a better understanding of HD-like superfamily genes and unravel the role of a potential HD-like gene in genetically controlling leaf size and venation patterning in birch, which provides clues to genetic improvement of woody plants with diverse geometric and topological properties of leaf vascular network.
Information, social networks and emotions: fear and anger towards Pedro Sánchez 2019–2021
Authors: Rivera José Manuel , Lagares Nieves , Jaráiz Erika , Pereira María
Published: January 2025

Introduction

The objective of this research is to determine the relationship between the use citizens make of social networks to learn about politics and the emotions expressed towards political leaders, taking as a case study the current Prime Minister of Spain Pedro Sánchez.

Methods

A quantitative methodological approach was used in this longitudinal study. This approach proposes both a descriptive and multivariate analysis of data from three databases.

Results

The analysis of results shows important differences between consuming political information on social networks and not doing so in terms of the type of negative emotions (anger and fear) generated towards Pedro Sánchez. Connecting these findings with previous cognitive approaches led us to conclude that, while fear encourages citizens to seek alternative information, when they seek it through social networks the expression of anger increases.

Discussion

In this sense, preliminary results suggest that fear towards Pedro Sánchez becomes anger when information is proactively sought in social networks.
Antecedents and consequences of political moral laxity: a Peruvian case
Authors: Espinosa Agustin , Anaya Rogger , Juárez Juan , Çakal Huseyin
Published: January 2025

Political Moral Laxity is defined as a set of beliefs and attitudes that tolerate and support dishonest or corrupt actions of authorities and politicians, especially when these actions benefit private interests to the detriment of the public good. Political Moral Laxity is the result of perverse political socialisation in political systems characterised by the lack of legitimacy of authorities, the weakening of institutions and, consequently, the non-compliance of citizens. The current study focuses on the mediating role of Political Moral Laxity between Social Dominance Orientation, the components of the Dark Triad of Personality, and Tolerance to Normative Transgression among Peruvian citizens. For this purpose, 242 Peruvian citizens of both genders (male = 45.9%, female = 53.7%, not specified = 0.4%), of legal age (Mage = 20.8, range 18–65), from the region of San Martin in the Peruvian Amazon were surveyed online. Results show that Political Moral Laxity fully mediate the effects of Social Dominance Orientation and only Psychopathy component of the Dark Triad on Tolerance to Normative Transgression. We discuss the results in terms of the Peruvian political system, which is heavily influenced by the neoliberal model, as well as the personality traits that predispose to Political Moral Laxity, thus reinforcing the negative effects of a political model on citizens’ dispositions to transgress.
Assessing self-determined motivation for drinking alcohol via the Comprehensive Relative Autonomy Index for Drinking
Authors: Courtney Jimikaye Beck , Russell Michael A. , Conroy David E.
Published: January 2025

Introduction

Self-Determination Theory (SDT) examines human motivation in multiple domains; however, the only existing measure assessing SDT-informed behavioral regulations for drinking focuses on responsible drinker behaviors, rather than drinking per se, which is important given the alignment between SDT and harm reduction approaches to alcohol use. The aim of this study was to test the structural validity of the SDT-informed Comprehensive Relative Autonomy Index for Drinking (CRAI-Drinking) among college students.

Methods

Participants included two convenience samples with a total of 630 adult drinkers (Mage = 21.5, 55% female, 88% undergraduates). Participants rated drinking behavioral regulations on the 24 original CRAI-Drinking items on a 5-point Likert Scale. Multi-dimensional scaling analyses and factor analyses were used to investigate the underlying autonomy continuum and factor structure of the CRAI-Drinking.

Results

In Sample 1 (n = 274), multi-dimensional scaling analyses confirmed that CRAI-Drinking item and subscale order aligned with SDT's autonomy continuum. Confirmatory factor analyses supported a five factor, 19-item model of the CRAI-Drinking with factors for intrinsic, identified, positive introjected, external, and amotivation regulations (Cronbach's α: 0.68–0.85). In Sample 2 (n = 356), a confirmatory factor analysis confirmed that the 19-item model fit was comparable to Sample 1.

Discussion

This study provides evidence for the structural validity of CRAI-Drinking scores for assessing SDT-based behavioral regulations for drinking in adults.
Empowering young athletes: the influence of autonomy-supportive coaching on resilience, optimism, and development
Authors: Zhang Na , Du Geng , Tao Tao
Published: January 2025

Introduction

The present study investigates how autonomy-supportive coaching style influences youth athlete development through psychological resilience and dispositional optimism. Despite growing interest in factors that contribute to athlete development, gaps remain in understanding how coaching approaches interact with psychological traits to foster youth athletes’ growth. This study addresses these gaps by proposing a serial mediation model in which autonomy-supportive coaching indirectly enhances athlete development through resilience and optimism.

Methods

Data were collected from 325 youth athletes and their coaches across training facilities and schools in China, and analyzed using structural equation modeling in SmartPLS.

Results

Results indicate that autonomy-supportive coaching style significantly increases psychological resilience, which in turn boosts dispositional optimism, positively impacting athlete development. Both resilience and optimism serially mediate the link between coaching style and athlete growth.

Discussion

These findings emphasize the importance of autonomy-supportive coaching in creating psychologically supportive environments that foster resilience, optimism, and developmental pathways in youth sports.
Influence of alexithymia severity in the healthy population on the susceptibility to false interoceptive feedback
Authors: Ikarashi Hitomi , Otsuru Naofumi , Takahashi Sena , Nagasaka Kazuaki , Hara Masayuki , Onishi Hideaki
Published: January 2025

Alexithymia is a psychological trait characterized by difficulty expressing emotions. Previous studies reported that individuals with higher alexithymia have a decreased sense of interoception, which is the sense of monitoring and controlling internal organs. Thus, we hypothesized that internal organ activity (cardiac activities in the present study) was easily affected by false feedback in individuals with severe alexithymia. Therefore, we investigated whether the effects of fake heart rate feedback on real cardiac activities differ depending on the severity of alexithymia as assessed by the 20-item Toronto Alexithymia Scale (TAS-20). Fake heart rate feedback was presented as if it were occurring in the individual’s hand through a virtual reality system at various speeds. Changes in cardiac activities were evaluated by the root-mean-square-successive difference (RMSSD, high value indicates greater parasympathetic tone) of the heartbeat interval. Our findings revealed a negative correlation between externally oriented thinking, a subscale of the TAS-20 score, and the RMSSD change ratio elicited by fake heart rate feedback. These findings indicate that individuals with higher alexithymia might be particularly susceptible to external fake feedback.
Predicting online shopping addiction: a decision tree model analysis
Authors: Wan Xueli , Zeng Jie , Zhang Ling
Published: January 2025

Background

Online shopping addiction has been identified as a detrimental behavioral pattern, necessitating the development of effective mitigation strategies.

Objective

This study aims to elucidate the psychological mechanisms underlying online shopping addiction through constructing and analyzing a C5.0 decision tree model, with the ultimate goal of facilitating more efficient intervention methods.

Methodology

A comprehensive survey was conducted among 457 university students in Sichuan, China, utilizing validated psychometric instruments, including the Online shopping addiction Scale, College Academic Self-Efficacy Scale, College Students’ Sense of Life Meaning Scale, Negative Emotion Scale, Social Anxiety Scale, Sense of Place Scale, and Tuckman Procrastination Scale.

Results

The predictive model demonstrated an accuracy of 79.45%, identifying six key factors predictive of online shopping addiction: academic procrastination (49.0%), sense of place (26.1%), social anxiety (10.1%), college students’ sense of life meaning (7.0%), negative emotions (7.0%), and college academic self-efficacy (0.9%).

Conclusion

This pioneering study in online shopping addictiononline shopping addiction prediction offers valuable tools and research support for identifying and understanding this behavioral addiction, potentially informing future intervention strategies and research directions. This study provides research support for improving people’s understanding and management of behavioral addictions and promoting healthier online shopping habits.
The efficacy of internet-based cognitive behavior therapy for psychological health and quality of life among breast cancer patients: a systematic review and meta-analysis
Authors: Lin Tang , Ping Yin , Jing Cai Ming , Xu Zhi Xiao , Ping Zhu
Published: January 2025

Objective

To systematically investigate the effect of Internet-based cognitive-behavioral therapy (ICBT) on depression, anxiety, fatigue and quality of life (QOL) in patients with breast cancer (BC).

Methods

A systematic review with meta-analysis and qualitative evidence synthesis was performed. Ten databases, including PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, JBI Chinese Biomedical database (CBM), China National Knowledge Infrastructure (CNKI), VIP, and Wanfang, were searched from the start till August 2023. Published studies in English or Chinese were eligible for randomized and clinical controlled trials determining the efficacy of ICBT among BC survivors. The quality of the evidence was evaluated at the study level and the outcome level.

Results

In total, 11 clinical trials on 1,307 patients with BC (ICBT: 671, control: 636) were systematically reviewed. We found that ICBT is effective in alleviating psychological distress in BC survivors, and the quality of all studies was moderate. The meta-analysis indicated that ICBT affected primary outcomes of anxiety (standardized mean difference [SMD] = −0.71, 95% confidence interval [CI]: −1.19, −0.24, p < 0.0001), depression (SMD = −0.67, 95% CI: −1.07, −0.27, p < 0.0001), fatigue (SMD = −1.23, 95% CI: −2.37, −0.08, p < 0.0001) and QOL (SMD = 0.79, 95% CI: 0.21, 1.37, p < 0.00001).

Conclusion

This meta-analysis indicates that ICBT, as a type of psychosocial rehabilitation, can mitigate the incidence of depression, anxiety, and fatigue and improve the quality of life among patients with BC. Nevertheless, the effect is not distinct, and multi-centered randomized controlled trials with larger cohorts are warranted to verify the effectiveness of ICBT.
Human perception of art in the age of artificial intelligence
Authors: van Hees Jules , Grootswagers Tijl , Quek Genevieve L. , Varlet Manuel
Published: January 2025

Recent advancement in Artificial Intelligence (AI) has rendered image-synthesis models capable of producing complex artworks that appear nearly indistinguishable from human-made works. Here we present a quantitative assessment of human perception and preference for art generated by OpenAI’s DALL·E 2, a leading AI tool for art creation. Participants were presented with pairs of artworks, one human-made and one AI-generated, in either a preference-choice task or an origin-discrimination task. Results revealed a significant preference for AI-generated artworks. At the same time, a separate group of participants were above-chance at detecting which artwork within the pair was generated by AI, indicating a perceptible distinction between human and artificial creative works. These results raise questions about how a shift in art preference to favour synthetic creations might impact the way we think about art and its value to human society, prompting reflections on authorship, authenticity, and human creativity in the era of generative AI.
Understanding the behavioral intentions of MaaS during public health events
Authors: Luo Hang , Ma Shoufeng , Tian Junfang , Dong Hongming
Published: January 2025

Introduction

Mobility as a Service (MaaS) integrates various modes of transportation, provides personalized travel services for travelers, and improves the efficiency of traditional travel modes. To examine the mechanisms underlying the impact of sudden public health events on the behavioral intentions to use MaaS and provide theoretical support for the sustainable development of MaaS, this research investigates the Beijing MaaS program as a case.

Methods

A total of 630 questionnaires were collected. Theoretical model, sourced from the Unified Theory of Acceptance and Use of Technology (UTAUT) model, is employed to elucidate the influence of six variables—performance expectancy, effort expectancy, social influence, ambiguity tolerance, perceived health threat, and policy cognition—on the behavioral intentions of MaaS.

Results

The results show that three variables from the UTAUT positively impact behavioral intention and that there is a significant mediating effect of policy cognition on the relationship between these variables and the intention to use. Travelers with a high level of ambiguity tolerance are more inclined to use MaaS, while the perceived health threat reduces the intentions.

Discussion

Multigroup analysis revealed differences in effort expectancy, ambiguity Toleance, and perceived health threat among the various groups. The research findings may provide theoretical guidance and empirical evidence for the promotion strategies of MaaS and for the formulation of related policies.
Post-training breakdown: acute effects of different training types on body hydration status and performance
Authors: Demirkan Erkan , Tosun Mehmet İsmail , Kaplan Abdurrahim , Ayrancı Mert , Cosmin Damian George , Arıcı Mustafa , Kutlu Mehmet , Aslan Veysi , Favre Michael
Published: January 2025

Objective

Wrestling is a complex sport that requires a combination of strength, endurance, and wrestling-specific technical training. Endurance activities, such as running, are commonly performed for rapid weight reduction before competition. However, these activities can severely disrupt recovery and lead to significant declines in performance. This study aimed to examine the acute effects of endurance, strength, and wrestling training sessions on hydration status and performance parameters in young wrestlers, providing insights to guide more effective hydration and recovery strategies.

Method

A total of 14 experienced young wrestlers participated in a crossover design, completing endurance, strength, and wrestling training sessions on separate days. The hydration status was assessed through urine specific gravity (USG) before and after each session. The performance measures included hand grip strength, back and leg strength tests, anaerobic power (vertical and horizontal jumps), respiratory muscle strength (maximal inspiratory pressure, MIP), and reaction time assessments.

Results

The endurance training caused the most significant acute reductions in the hydration (USG increase: 0.016 ± 0.005 g/cm3, p < 0.05) and body mass (BM; −1.89 ± 0.4%, p < 0.05), along with immediate performance decrements in the back strength (−7.02 ± 1.2%, p < 0.001), right-hand grip strength (−8.79 ± 2.1%, p < 0.001), jump height (−7.26 ± 1.8%, p < 0.001), and MIP (−9.01 ± 2.3%, p < 0.001). The hydration levels in the endurance group did not fully recover by the next day (USG post-training vs. before the next day’s training: p < 0.05). In contrast, the strength training improved the reaction time before the next day’s session (+5.6 ± 1.3%, p < 0.05), while the attention remained unaffected across all training types.

Conclusion

Endurance training—commonly used for rapid weight loss—can acutely compromise hydration and reduce key performance measures, with recovery taking more time compared to strength or wrestling sessions. Given these findings, endurance sessions should be strategically scheduled before rest days or low-intensity technical training to minimize their negative effects on subsequent performance. Implementing enhanced hydration strategies during endurance-focused sessions may also help mitigate these acute impacts and optimize recovery and performance in young wrestlers.
Associations of lamplight exposure during sleep and sleep duration with attention-deficit/hyperactivity disorder among preschool children in China
Authors: Jiang Hui , Yu Bin , Liu Yuanyang , Gao Hui , Song Ruijuan , Tan Siyue , Han Shufen , Zuo Hui
Published: January 2025

Introduction

This study aimed to examine the associations of exposure to light while sleeping at night and different sleep durations with attention-deficit/hyperactivity disorder (ADHD) among preschool children in China.

Methods

A cross-sectional study including 4197 preschool children (2190 boys and 2007 girls) was conducted in 2021. Lamplight exposure during sleep and sleep duration were collected via a validated questionnaire. ADHD was assessed using the Conners Parental Symptom Questionnaire (PSQ). Associations of exposure to light while sleeping and sleep duration with ADHD were examined by multivariable logistic regression models.

Results

The overall prevalence of ADHD was 3.7%. Compared to the children who slept with the lamplight off at night, those who slept with the lamplight on ≥3 nights/week were more likely to have ADHD after multivariable adjustment (OR=3.37; 95% CI: 1.95, 5.82; P-trend <0.001). The risk associations of lamplight exposure during sleep with ADHD were similar in subgroups stratified by sex, picky eating, gestational hyperglycemia, and gestational anemia. Moreover, compared to the children with sleep duration of 10-12 hours/day, adjusted OR for ADHD was 1.64 (95% CI: 1.14, 2.35) for those with sleep duration <10 hours/day and 2.69 (95% CI: 1.12, 6.44) for those who slept>12 hours/day.

Discussion

Lamplight exposure during sleep at night was positively associated with ADHD among preschool children. Also, both sleep duration of <10 hours/day and >12 hours/day increased the likelihood of ADHD. Our novel findings suggest the importance of sleeping habit on the prevention of ADHD. Prospective and interventional studies are warranted to elucidate the observed associations.
Basic self-disorders may play a role in the development of depression in schizophrenia: a seven-year follow-up study
Authors: Haug Elisabeth , Øie Merete Glenne , Svendsen Ingrid Hartveit , Møller Paul , Nelson Barnaby , Melle Ingrid
Published: January 2025

Introduction

Depression is the most common co-morbid psychiatric disorder in patients with schizophrenia and has a negative effect on functional outcomes and quality of life. There are several possible pathways leading to depressive symptoms in schizophrenia. Self-disorders are disturbances in the deepest, pre-reflective level of the self and are suggested to be core features of schizophrenia. The relationship between self-disorders, and depressive symptoms has only been studied to a limited extent, and there are no longitudinal studies. This study aimed to explore the relationship between self-disorders at baseline and the development of depression over the follow-up period

Methods

Self-disorders were examined with the Examination of Anomalous Self-Experience (EASE) instrument in 31 patients with schizophrenia during their first treatment. Seven years later we measured the total number of depressive episodes since the start of treatment.

Results

We found a clear association between self-disorders at baseline and the total number of depressive episodes over the follow-up period.

Discussion

Self-disorders may play a role in the development of depression in schizophrenia. This may have implications for therapeutic approaches targeting a condition that is characterized by considerable suffering and an elevated risk of suicide.
Bacteriological quality and predictors of raw meat collected from municipal slaughterhouse and butcher shops in northeast, Ethiopia
Authors: Berhanu Leykun , Gizeyatu Adinew , Abebe Masresha , Teshome Daniel , Aragaw Mohammed , Berihun Gete
Published: January 2025

Background

Meat is a good source of protein in the human diet, and more than three-quarters of the world’s population consumes it. It is the most perishable food item since it has enough nutrients to enable microbial growth. In underdeveloped nations, animals are routinely slaughtered and sold in unsanitary conditions, compromising the bacteriological quality and safety of the meat received from the animals. To protect customers’ health from numerous foodborne diseases this study aimed to determine the microbial quality and predictors of meat along the meat value chain in Northeast, Ethiopia.

Objective

To determine the bacteriological quality of meat and its predictors obtained from the Dessie City Administration’s municipal slaughterhouse and butcher shops.

Materials and methods

A laboratory-based cross-sectional study design was used. In total 177 meat and 354 swab samples were collected. In addition, 177 meat handlers were randomly selected for knowledge, attitude, and practice assessment. All the samples were analyzed for the presence and counts of total viable count, total coliform count, fecal coliform count, and S. aureus. Multiple linear regression and student T-tests were used to analyze the data. Statistical significance was defined at a p-value of less than 0.05.

Results

The total viable count of meat samples collected from slaughterhouse and butcher shops were 5.17 ± 0.13 and 6.5 ± 0.87 log CFU/g, respectively. The overall mean total viable count of the meat samples was 5.8 ± 0.1 log CFU/g. Meat samples collected from butcher shops were more highly contaminated than those collected from slaughterhouse. Hand hygiene of meat handlers, the microbial quality of water, and the educational status of meat handlers are all significant predictors of the microbial quality of raw meat along the meat value chain.

Conclusion and recommendation

The meat microbial quality is poor and deteriorates along the meat value chain. The hands of meat handlers, the microbial quality of water used to wash the hands of meat handlers, and the educational status of meat handlers significantly affect the microbial quality of raw meat along the meat value chain. Hence, measures should be taken to improve the personal hygiene status of meat handlers and the quality of water used to wash hands and meat contact surfaces.
Incidence of severe maternal outcomes following armed conflict in East Gojjam zone, Amhara region, Ethiopia: using the sub-Saharan Africa maternal near-miss criteria
Authors: Kebede Tirusew Nigussie , Abebe Kidist Ayalew , Malede Ambachew Getahun , Sisay Abinet , Yirdie Ayenew , Taye Worku , Moltot Kitaw Tebabere , Fente Bezawit Melak , Tadese Mesfin , Demisse Tesfanesh Lemma , Silesh Mulualem , Beshah Solomon Hailemeskel , Tiche Getaneh Dejen , Amera Tizazu Michael , Chekole Moges Sisay , Taye Birhan Tsegaw
Published: January 2025

Background

Severe maternal outcome (SMO) encompasses women who survive life-threatening conditions either by chance or due to treatment quality, or who die. This concept assumes that severe maternal morbidity predicts mortality risk, enabling the analysis of risk factors for life-threatening outcomes and improving our understanding on the causes of maternal death. This study aims to determine the incidence of SMO and its leading causes in East Gojjam during a period of regional conflict.

Methods

A prospective follow-up study was conducted at Debre Markos Comprehensive Specialized Hospital in East Gojjam from July 1, 2023, to February 30, 2024. The study included 367 women admitted with potentially life-threatening conditions, including 8 maternal deaths, using sub-Saharan Africa (SSA) and WHO Maternal Near-Miss (MNM) criteria. Data were entered into Epi Data v.4.6 and analyzed using SPSS v.27. The WHO MNM approach assessed SMO indicators and maternal health care quality were utilized.

Results

During the eight-month period, there were 3,167 live births, 359 potentially life-threatening conditions (PLTC), and 188 SMO cases (180 MNM and 8 maternal deaths). The SMO ratio was 59.4 per 1,000 live births (95% CI: 51, 68 per 1,000 live births). The MNM to mortality ratio, mortality index, and maternal mortality ratio were 22.5:1, 4.2%, and 252.6 per 100,000 live births, respectively. Over 80% of women with SMO showed evidence of organ dysfunction upon arrival or within 12 h of hospitalization. The leading causes of SMO were hypertensive disorders of pregnancy (HDP) and obstetric hemorrhage, including uterine rupture, with uterine rupture contributing to half of the maternal deaths.

Conclusion

This study found that the incidence of SMO was comparable to that reported in most other studies. HDP was the primary cause of SMO, followed by obstetrical hemorrhage, consistent with other studies in Ethiopia. Uterine rupture was identified as the leading cause of maternal death. As this study was conducted in a single institution and in the period of severe armed conflict, it may not fully capture the range of maternal health issues across populations with varying healthcare access and socio-economic backgrounds. Caution should be exercised when generalizing these findings to the wider population.
Climate change and suicide epidemiology: a systematic review and meta-analysis of gender variations in global suicide rates
Authors: Chen Dan-Dan , Tu Jin-Heng , Ling Ke-Nan , Jin Xiao-Hong , Huang Hai-Yan
Published: January 2025

Background

Climate change is reshaping public health, introducing extreme weather conditions and environmental stressors—such as high temperatures, atmospheric pollution, desertification, and storms (rain, thunder, and hail)—that critically impact mental health. Evidence increasingly links these factors to higher rates of suicide-related outcomes, including suicidal ideation, attempts, and self-harm. Such interactions underscore the importance of understanding how climate-driven mental health risks vary by environmental factor and gender, as gender-specific vulnerabilities shape responses to climate stressors.

Methods

By April 16, 2024, we conducted a comprehensive search of PubMed, Web of Science, Cochrane Library, PsycINFO, Scopus, ProQuest, and Embase. Two researchers independently reviewed studies and collected demographic data, systematically tracking and recording rates of suicidal ideation, suicide attempts, suicide deaths, self-harm, and anxiety. Data were rigorously cross-verified for accuracy and consistency.

Results

The meta-analysis demonstrated significant associations between climate change variables and mental health outcomes. High temperatures and air pollution were linked to increased suicide attempts (OR: 1.40, 95% CI: 1.34–1.45) and suicide deaths (OR: 1.51, 95% CI: 1.44–1.58), particularly among males. Conversely, atmospheric pollution and desertification correlated with a reduced likelihood of suicidal ideation (OR: 0.73, 95% CI: 0.63–0.85). These findings highlight gender-specific mental health impacts, with females exhibiting higher rates of anxiety and self-harm, underscoring the urgent need for targeted interventions addressing climate-induced mental health risks.

Conclusions

This systematic review and meta-analysis reveal significant gender-specific mental health impacts of climate change, with females experiencing higher rates of anxiety, self-harm, and suicidal ideation, while males show greater incidences of suicide attempts and deaths. These findings emphasize the urgent need for targeted interventions and the integration of mental health services into climate policies to address these gender disparities.

Systematic review registration

This study is registered with PROSPERO [PROSPERO (york.ac.uk)] under the identifier [CRD42024534961].