bluuebunny/crossref_metadata_2025 huggingface dataset:
Latin, Teaching and COVID-19: Reflections and Suggestions
Authors: Balbo Andrea
Published: April 2021

This article aims to discuss the regulatory and legal problems caused to teaching activities by the COVID-19 pandemic in the Italian schools and it focuses on the first results of the impact of COVID-19 on Latin teaching activities, highlighting some good practices that might be used in future in the everyday life of students and teachers. In particular, it focuses on the role of online open access resources, underlying the difference between digital teaching and distance learning and teaching. At the end, the article discusses also the future perspectives of teaching classics in a context where distance teaching seems still far from being abandoned.
Development of a Kanji Reference Tool and its Moodle Integration
Edukanji 2.0: Design, Development and Implementation
Authors: Mantelli Alessandro
Published: April 2021

Due to the COVID-19 emergency, Ca’ Foscari University of Venice has reorganized a large part of its courses for on-line delivery through the LMS Moodle. Unfortunately, this platform, besides having a particularly complex interface to use, does not have modules dedicated to the teaching of Japanese. Addressing this issue, this paper proposes the design of a module for kanji teaching integrated with the Moodle workflow, to produce complete and printable kanji sheets with all the necessary information, thus reducing teacher workload. The methodology used derives from an Instructional System Design development model (SAM, Successive, Approximation Model) that allows continuous feedback from the teacher, so as to adapt the developed prototype to his/her teaching needs.
Robotic Process Automation statt neuem ERP-System
Authors:   Universität Potsdam, Gronau Norbert , Bender Benedict ,   Lehrstuhl für Wirtschaftsinformatik, Bertheau Clementine , Laube Hannah
Published: April 2021

Robotic Process Automation (RPA) steht für die softwareunterstützte Bedienung von Softwarelösungen über deren Benutzeroberfläche. Das primäre Ziel, das mit RPA erreicht werden soll, ist die automatisierte Ausführung von Routineaufgaben, die bisher einen menschlichen Eingriff erforderten. Das Potenzial von RPA, Prozesse langfristig zu verbessern, ist allerdings stark begrenzt. Die Automatisierung von Prozessen und die Überbrückung von Medienbrüchen auf der Front-End-Ebene führt zu einer Vielzahl von Abhängigkeiten und Bedingungen, die in diesem Beitrag zusammengefasst werden. Der Weg zu einer nachhaltigen Unternehmensarchitektur (bestehend aus Prozessen und Systemen) erfordert offene, adaptive Systeme mit moderner Architektur, die sich durch ein hohes Maß an Interoperabilität auf verschiedenen Ebenen auszeichnen.
Comunicación digital entre ediles y usuarios en Twitter: Oportunidad fallida en el fortalecimiento de imagen y vigencia en la esfera pública
Authors: Bohórquez Pereira Giovanni , Flórez Quintero Juan Diego , Alguero Montaño Miguel Orlando
Published: April 2021

Objetivo: determinar el uso de la red social Twitter por los concejales de Bucaramanga en su ejercicio como servidores públicos y líderes de opinión local, mediante la hipertextualidad, popularidad, interactividad, participación, multimedialidad e interacción. Metodología: se acude a la Netnografía con el uso de técnicas mixtas: entrevista semiestructurada y aplicación del Índice Global Potencial Persuasivo de Twitter. Resultados: se encontró que el Concejo en su proceso de divulgación pública utiliza un portal web, con información actualizada sobre sus actividades. Usa Facebook, Twitter y Youtube, pero sus registros de interacción y uso de multimedia son reducidos. Catorce de los diecinueve concejales tienen Twitter, tres de ellos marcan actividad y los contenidos difundidos sobre su ejercicio legislativo son limitados; el contenido multimedia publicado es bajo, igual que las respuestas e interacciones con usuarios. Conclusiones: se concluye que avanza la inmersión en la comunicación pública de las plataformas digitales y redes sociales para orientar y difundir el ejercicio político y más desde el campo legislativo, punto que ya los gobernantes locales y globales han entendido. Los concejales que participaron en esta investigación decepcionan al centrar el uso de Twitter en hablar de temas desligados de su función y pierden una gran oportunidad desde su microblogging para hacer propuestas relacionadas con las problemáticas sociales y contribuir desde su cuenta Twitter a consolidar su imagen y vigencia en la esfera pública y electoral.
The Relationship between Content Used, Time Spent and Cyberbullying on Social Media with Social Skills
Authors:   Kolej University Poly-Tech MARA, Jalan 6/91, Taman Shamelin Perkasa, Cheras, 56100, MALAYSIA, Megat Ibrahim Nan Zakiah , Ibrahim Mohammad Shamsul ,   Kolej University Poly-Tech MARA, Jalan 6/91, Taman Shamelin Perkasa, Cheras, 56100, MALAYSIA
Published: April 2021

Based on the past research, there are still limited studies in proving content used on social media, time spent on social media, cyberbullying contributes to the social skills that are deemed unimportant and irrelevant in Malaysia. Therefore, this study is intended to show the variables do have a relationship with one another, determining each of the objectives in this research is proven right. This study applied the Theory of Planned Behaviour as the main theory to fortify and take the relationships at a greater distance between each variable. Quantitative methods were applied in this study and data were collected through the distribution of questionnaires to 181 respondents who were students at Kolej Universiti Poly-Tech MARA pursuing a Diploma in Corporate Communication. Besides, the findings showed a significant relationship between content used on social media, time spent on social media, cyberbullying to behaviour, and the reaction of an individual. Established evidence between variables that are, content used on social media, time spent on social media and cyberbullying is affecting behaviour and reaction of an individual. Hence, this study assisted the field of communication through the establishment of a more comprehensive variable related to the behaviour and reaction of an individual and supported to Planned Behavior Theory.
Too Generous and Committed: Hullabaloos over Nigerian Foreign Policy Objectives
Authors:   School of International Studies, College of Law, Government and International Studies (COLGIS), Universiti Utara Malaysia (UUM), Sintok, 06010, MALAYSIA, Dauda Muritala , Ahmad Mohammad Zaki ,   School of International Studies, College of Law, Government and International Studies (COLGIS), Universiti Utara Malaysia (UUM), Sintok, 06010, MALAYSIA, Keling Mohammad Faisol ,   School of International Studies, College of Law, Government and International Studies (COLGIS), Universiti Utara Malaysia (UUM), Sintok, 06010, MALAYSIA
Published: April 2021

Nigeria’s afrocentric foreign policy has in no small measure benefited African continent. This has assisted Nigeria tremendously to have played a leading role towards ensuring peace, stability, cooperation and development in the African continent. The study examines the hullabaloos surrounding the too generous and committed nature of Nigerian foreign policy which has canvassed for varieties of opinions on the need for the country to adjust her foreign policy objectives. The study indicates that if there is need for Nigeria to adjust her foreign policy objectives towards Africa, it should be more favourable and not the other way round due to numerous unforeseen benefits. The study adopts role theory to describe the position and responsibility shouldered by Nigeria in Africa. As against the position opined by antagonists on the amendment of Nigerian foreign policy’s objectives, the theory explains that some benefits are either tangible or intangible forms. This study is qualitative that adopts both primary and secondary sources of data. Twelve (12) respondents were interviewed from various Nigerian government parastatals and higher institutions of learning. Data gotten from the interview was analysed thematically with the aid of Nvivo. The secondary data source was through books, journal articles, newspapers and policy documents.
The CEFR Impact on English Language Educators Teaching Engineering Programmes at a Private University in Malaysia
Authors:   Universiti Tenaga Nasional,  Kajang, Selangor, 43000, MALAYSIA, Abd Rahman Ahmad Zufrie , Chong Seng Tong ,   Universiti Tenaga Nasional,  Kajang, Selangor, 43000, MALAYSIA, Kaman Zeittey Karmilla ,   University Malaya, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, 50603, MALAYSIA, Leon Carol Elizabeth ,   University Malaya, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, 50603, MALAYSIA
Published: April 2021

This paper presents some preliminary findings of a multi-dimensional and interdisciplinary research. It explores the experience of language educators on the newly implemented policy by the Ministry of Education, Malaysia. The implementation of the Common European Framework of Reference for Languages (CEFR) is a policy that develops through a whole continuum: from primary schools to universities. The paper fills the gap in terms of impact studies of the CEFR especially on engineering programmes where the desired CEFR levels are higher. This implementation affects language educators at university in various domains such as the required CEFR levels for language educators, teaching materials and support systems. The methodological framework used in this study is phenomenological study. It aims to explore the experience of the language educators. Interviews were conducted on three language educators teaching engineering programmes at a private university. Snowballing technique was used in identifying the research interviewees. Data gathered were analysed using Atlas.Ti, a qualitative analysis software. Preliminary result indicates that language educators were positive and welcome enthusiastically the change. However, challenges were immense and critical. This paper concludes that the implementation of the CEFR is a wise move for Malaysian students towards a higher level of proficiency in English.
Analisis Teknologi Laboratoris Gerabah Dari Situs Leran
Authors: Intan Fadhlan S.
Published: April 2021

Secara umum gerabah dari Situs Leran, Gresik, Jawa Timur, termasuk dalam kategori gerabah dengan kualitas yang cukup baik, dengan ditemukannya mineral mafic dan mineral felsic, yang sangat berpengaruh terhadap warna-wama gerabah. Tingkat kekerasan yang rendah (2-4 Skala Mohs), lebih banyak disebabkan oleh faktor lingkungan tempat gerabah-gerabah tersebut ditemukan, yaitu berada pada suatu lingkungan yang berair, sehingga berpengaruh terhadap ikatan-ikatan antar mineral, yang pada akhirnya akan mempengaruhi tingkat kekerasan gerabah tersebut.
Bentuk Makam-Makam Belanda Di Cilacap Dan Purworejo
Authors: Chawari Muhammad
Published: April 2021

Makam-makam Belanda yang terdapat di Indonesia - khususnya Jawa, lebih khusus lagi di Cilacap dan Purworejo - mempunyai bentuk yang khas. Bentuk-bentuk tersebut sangat berbeda dengan bentuk-bentuk makam orang-orang pribumi pada umumnya. Perbedaan tersebut tidak hanya pada bentuk makam, tetapi juga ukuran, dan variasinya. Dengan mempelajari bentuk-bentuk makam Belanda tersebut dapat diketahui latar belakang adanya perbedaan bentuk makam antara satu individu dengan individu yang lain dalarn masyarakat Belanda di Indonesia.
Uluabat Gölü Ramsar Alanının Ekoturizm Açısından Değerlendirilmesi
Authors: AKBANA Ayşenur , BULUT Yahya
Published: April 2021

Kitle turizminin çevre üzerinde oluşturduğu yıkıcı etkiye karşın, doğal alanlara gerçekleştirilen, çevreye duyarlı bir turizm şekli olarak ortaya çıkan ekoturizm, bir planlama dâhilinde gerçekleştirildiğinde özellikle sulak alanlar gibi hassas ekositemlere sahip alanlarda sürdürülebilir kullanımın sağlanması ve yöre halkının kalkınması açısından önemli bir fırsattır. Bu çalışmada ülkemizdeki 14 Ramsar alanından biri olan Uluabat Gölü Ramsar alanı tampon bölge sınırları içerindeki ekoturizm potansiyeli belirlenmeye çalışılmıştır. Literatür taramaları, arazi çalışmaları ve SWOT analizi tekniğinden yararlanılan çalışma sonucunda çalışma alanı sınırları içerisindeki ekoturizm potansiyeli yüksek yerleşim alanları ve bu yerleşim alanları ile yakın çevrelerinde gerçekleştirilebilecek ekoturizm aktiviteleri ortaya konulmuştur. Ekoturizm sonucunda oluşabilecek tehditlere karşın, sürdürülebilir kullanımın sağlanabilmesi adına önerilere yer verilmiştir.
PETROLOGICAL-GEOCHEMICAL FEATURES OF BASALTS OF 2776 AND 2764 DREGING STATIONS (PHILIPPINE SEA)
Authors:   V.I.Ili’ichev Paific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences, Emel'yanova T.A. , Melnichenko Yu.I. ,   V.I.Ili’ichev Paific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences, Pugachev A.A. ,   V.I.Ili’ichev Paific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences, Lee N.S. ,   V.I.Ili’ichev Paific Oceanological Institute, Far Eastern Branch, Russian Academy of Sciences
Published: April 2021

The article presents original data of the radioisotope age and composition of rare elements in basalts of dredging stations 2776 and 2764 located in the southern part of the Central Fault in the Philippine Sea. Researchs have shown that basalts of st. 2776 demonstrate the chemical features of tholeiites of middle-oceanic ridges and oceanic island arcs (N-MORB+OIAB). And basalts of st. 2764 combine the features of E-MORB+OIAB. A comparative analysis of the chemical composition of the volcanics of both stations and of the Kyushu-Palau Ridge shows that all rocks are united by the enrichment of melts with a «subductional» and withinplate (WPB) components. But WPB features in the rocks are mostly manifested at the level of the Primitive Mantle (PM), and these features have not reached to the level of alkaline basaltoids of the ocean islands (OIB).
Los dos autores de la Florida
Authors: Durand José
Published: April 2021

Vislumbrar el misterio de la creación y composición de la Florida del Inca, equivale a entrar en la historia de una entrañable amistad: la del conquistador Gonzalo Silvestre y el Inca Garcilaso de la Vega. En el Premio al letor el propio Garcilaso cuenta cómo de repetidas conversaciones con un amigo suyo, cuyo nombre oculta, nació el deseo de escribir esa obra. Silvestre, de edad mucho mayor que el Inca, había estado en la jornada de Hernando de Soto en la Florida y luego pasó al Perú, en donde alcanzó a defender el pendón real durante las guerras civiles de Gonzalo Pizarro y Francisco Hernández Girón, que por entonces alborotaron la tierra.
La filosofía y la ciencia
Authors: Saco Gustavo
Published: April 2021

La historia de la filosofía nos enseña que la cuestión primordial de la disciplina filosófica es la concerniente a la naturaleza del ser. Esa misma historia revela que para responder a la cuestión primordial del ser, la respuesta materialista y la respuesta espiritualista son las únicas que se disputan el derecho a representar a la verdad definitiva. A su vez, acerca de la naturaleza material o espiritual del ser, los filósofos, en el transcurso de la historia, solamente han hallado, por un lado, la posición monista materialista, o la posición monista espiritualista y, por otro lado, la posición dualista que acepta que subsisten dos entes, el uno materia y el otro espíritu que de algún modo se interrelacionan, pero que en lo substancial son de una naturaleza irreductible.
El concepto de realidad
Authors: Bobbio Rosas Fernando
Published: April 2021

Lo que nos interesa —y nos proponemos presentar en este trabajo—, es una clasificación de la realidad desde el punto de vista de nuestra experiencia sensible inmediata que es —no la percepción absolutamente pura, que parece que no existe, sino— la que experimentamos corriente y cotidianamente los que somos simples mortales sencillamente racionales y no filósofos racionalistas —o empiristas, o lo que sea— cargados con el lastre de más de dos milenios y medio de errores, prejuicios y confusiones filosóficas.
Envés y reflexión de lo huachafo
Authors: Pinto Gamboa Willy F.
Published: April 2021

En el lapso del 79 al nuevo siglo, el Perú entre otros hechos supera con dificultad la crisis que le había traído la derrota. "La guerra con Chile no sólo derramó nuestra sangre, expuso a la luz del sol nuestra lepra", había manifestado acusativo don Manuel González Prada. En el sur, en Arequipa, turbas regimentadas queman en monigotes, en un mitin, a Francisco Mostajo, a José Angel Escalante y a Mariano Lino Urquieta, que a su turno animaban El Ariete. Aspera polémica entre el pierolismo y El Comercio: "Ustedes y sus amigos (el civilismo) están matando al Perú", enrostrará al decano nacional, don Nicolás de Piérola. El autor de Horas de lucha, se aleja de la "Unión Nacional", el radicalismo en la escena de la política peruana, "porque conocía a los hombres. No había en ellos ni ideas ni ideales y sí una ausencia total de lealtad y honradez —como "confiesa" a Félix del Valle en un reportaje dos años antes de su muerte. Hace su ingreso en la verba populcrr el término huachafa, que una realidad sui generis le había llevado a inventar a Jorge Miota; término feliz recogido a posteriori para el mundo literario por la escritura, "esa haragana artillería hacia lo invisible", según definición de Jorge Luis Borges.
La Cultura Vicús - Hallazgos y expresiones artísticas
Authors: Saco María Luisa
Published: April 2021

Analiza la cultura Vicus en la época en que la civilización Chavín, que abarcó gran parte del territorio del Perú, dejó de ejercer su influjo dominante, floreció en la región del Norte la cultura Vicús, en cuyo arte se manifiestan ciertas cualidades que alcanzaron su apogeo en el más importante estilo norteño, el estilo Mochica. En el de Vicús se observa, aunque en estado incipiente, la tendencia a la representación realista, el fuerte modelado escultórico y el carácter vital quehallamos en las expresiones artísticas Mochicas. La cultura Vicús fue descubierta hace apenas dos décadas. En 1953, cerámica y objetos de oro de este estilo, que habían sido extraídos clandestinamente de los cementerios de Frías, en la provincia de Ayábaca, fueron decomisados por la policía. Otros ejemplares fueron adquiridos por coleccionistas particulares. Uno de los primeros arqueólogos que visitó dicha zona fue Ramiro Matos Mendieta, quien, en 1963, fue comisionado por el' Patronato Nacional de Arqueología para verificar la procedencia de los huacos cuyo estilo era conocido cori el nombre de Ayabaca
La Sociología del drama moderno en Lukacs
Authors: López Soria José I
Published: April 2021

Explica que la sociología de la literatura se presenta entonces como un camino hacia la construcción de una nueva cultura que responda y se adecúe a las exigencias del "hombre problemático". No es raro, por tanto, que en este esfuerzo por echar las bases de una nueva cultura esté siempre presente la cultura greco-latina como paradigma. La atribución de paradigmaticidad a las "culturas cerradas" no lleva, sin embargo, a Lukács a enfatizar la necesidad de reconstruirlas. De lo que se trata, pues, es de posibilitar una cultura para el hombre problemático. El pensaT lukácsiano arranca de esta vivencia fundamental ydesde ella se lanza a una terca búsqueda de caminos de salida
Filosofía y ciencias sociales
Authors: Sobrevilla David
Published: April 2021

En esta ponencia nos proponemos examinar cómo puede plantearse esta coordinación, y en este sentido cuál es la contribución que puede prestar la filosofía a las ciencias sociales y, a la inversa, cuál es la colaboración que éstas son capaces de brindar a acuella—- en efecto no se trata tan sólo de considerar unilateralmente Ma posible utilidad del filósofo en la ciencia social" (Mario Bunge), sino también la del científico social en la filosofía. Previamente nos referiremos a algunas diferencias entre la filosofía y las ciencias sociales.
Comunicación e imaginario popular
Authors: Blanco Desiderio
Published: April 2021

Tanto el discurso sociológico como el discurso político, educacional y moral sobre la comunicación social, insisten en señalar que el público receptor esta condicionado por los mensajes en su actitud receptiva. Es decir, que el cine, la televisión y la radio forman el gusto (=el mal gusto) del receptor.
Gottron’s carcinoid papillomatosis of skin (features of clinical course, diagnosis and treatment, own clinical observation)
Authors: Lytynska T.О. , Demchenko O.V.
Published: April 2021

Objective — to study the features of the clinical course, diagnosis and rational approach to the treatment of Gottron’s carcinoid papillomatosis of skin.Materials and methods. The article presents current data on the clinical course, pathomorphological criteria, diagnosis and treatment of Gottron’s carcinoid papillomatosis of skin. The authors’ own clinical observation is given.Results and discussion. Gottron’s carcinoid papillomatosis of skin is dermatosis that is quite rare in medical practice. The disease is characterized by a long course with a permanent progression of the pathological process. In the vast majority of patients, this pathology develops against the background of other chronic dermatoses such as psoriasis, eczema, lichen planus, pemphigus. In addition, these patients are diagnosed with concomitant multiorgan somatic pathology, which causes not only severe course and recurrence of this dermatosis, but also requires a comprehensive approach to the treatment of these patients, taking into account the identified somatic pathology.Conclusions. Gottron’s carcinoid papillomatosis of the skin is characterized by a long course against the background of permanent progression of the pathological process.Treatment of patients with Gottron’s carcinoid papillomatosis should be comprehensive and individualized, taking into account the severity of dermatosis and concomitant pathology, which is predominantly multiorgan in nature and in some cases causes severe dermatosis and resistance to traditional therapy. This clinical case indicates a significant regression of clinical manifestations of dermatosis in patients with long­term disease, provided the correct diagnosis and adequate therapy.
Experience in using Topicream soothing cream CICA for rehabilitation of skin and mucous membranes after destructive dermatocosmetological procedures in combination therapy of dermatoses
Authors: Hrechanska L.V. , Podluzhna O.V. , Ostapenko S.Р. , Alatorskyh А.Е.
Published: April 2021

The widespread introduction of the destructive methods of treatment into the clinical practice of dermatovenerologists is caused by the significant spread of benign skin and mucous neoplasms. At the same time, any effect on the skin — chemical, physical or mechanical — causes damage. Thus, patients using these procedures need proper care for damaged skin and mucous membranes to prevent secondary infection and scaring. Disruption of the epidermal barrier after removal of benign skin neoplasms, carrying out biopsy and chemical peels always requires application of topical agents promoting full recovery of the epidermis. In addition, many skin diseases are accompanied by inflammatory reactions, which are complicated by secondary infection. The use of drugs with anti­inflammatory and reparative properties reduces the duration of treatment and promotes skin recovery.Objective — to evaluate the clinical efficacy and tolerability of using Topicream soothing cream CICA after derma­tocosmetological procedures on the skin and mucous membranes and to investigate the efficacy of its use at various skin and mucous membranes diseases including children.Materials and methods. The study included 57 patients aged 1 to 75 years with various skin diseases, benign skin and mucosal neoplasms, after punch biopsy and cosmetology procedures. Topical application of the Topicream soothing cream CICA on the damaged skin and mucosal areas was recommended to all participants of the study twice a day. Results and discussion. The use of the regenerating cream after dermatological treatment of benign skin neoplasms with apparatus methods, chemical peelings and punch biopsy, as well as the auxiliary treatment of skin diseases such as cheilitis, herpes, perianal fissure, allergic contact dermatitis (including in children) localized in folds and on the face, contributes to a significant reduction in signs of inflammation and subjective sensations, as well as rapid healing of the affected skin surface. At the same time, there is a good tolerance and the absence of side effects of Topicream soothing cream CICA, which allows it to be widely used in clinical dermatovenerology, gynecology and pediatrics.Conclusions. High efficiency and safety of Topicream soothing cream CICA allow its widespread use in clinical practice of dermatovenerologists, gynecologists and pediatricians.
Analysis of clinical and diagnostic features and criteria for the effectiveness of treatment of autoimmune bullous dermatoses pemphigus group
Authors: Zapolsky М.Е. , Lebediuk М.М. , Prokofyeva N.B. , Goncharenko V.V. , Nerubashchenko S.V.
Published: April 2021

The modern classification of autoimmune bullous dermatoses is represented by three groups of diseases that have not only clinical, but also histomorphological, histochemical and immunogenetic similarities. Autoimmune bullous dermatoses are a group of heterogeneous diseases accompanied by the formation of blisters and erosions on the skin and/or mucous membranes under the influence of specific autoimmune complexes. The main clinical manifestations and diagnostic markers of autoimmune bullous dermatoses (ABD) belonging to the pemphigus group are considered.Objective — to analyze the prevalence of clinical forms of pemphigus in the southern region of Ukraine for the period from 2010 to 2020.Materials and methods. The observation group consisted of 88 patients aged 21 to 75 years. The features of clinical manifestations of typical and atypical forms of pemphigus have been studied, a diagnostic algorithm and criteria for the effectiveness of treatment in the early stages of the disease have been developed.Results and discussion. Pemphigus vulgaris was found in 61 (69.3 %), pemphigus vegetans — in 7 (7.9 %), pemphigus erythematosus — in 6 (6.8 %), herpetiform pemphigus — in 4 (4.5 %), IgA pemphigus — in 3 (3.4 %), paraneoplastic pemphigus — in 3 (3.4 %) patients.Conclusions. Modern clinical diagnostic features of ABD (pemphigus group) require the inclusion of immunofluorescence microscopy, direct and indirect enzyme immunoassay in laboratory screening. Not only positive clinical dynamics, but also the rate of disappearance of autoantibodies that induce the diseases (desmoglein, desmoplakin, periplakin, etc.) should be considered the criteria of the effectiveness of treatment of patients with ABD. At the same time, knowledge of the clinical features of ABD and the diseases that mimic them remains an important aspect.
Diverticular colon disease in patients with type 2 diabetes mellitus
Authors: Dorofeyev A. E. , Tkach S. M. , Derkach I. A. , Gdal V. A. , Dinya Yu. Z. , Chiwendu Beniah Ojum
Published: April 2021

The aim of this study was to investigate the prevalence and features of the course of diverticular colon disease in patients with type 2 diabetes mellitus in the population of Ukrainian patients, as well as to analyze the effectiveness of the use of combination therapy using dietary fiber and rifaximin in these patients.
Materials and methods. We observed 140 patients with type 2 diabetes mellitus (DM 2). The age of the patients ranged from 39 to 69 years (mean age 53.1 ± 5.2 years), among the patients there were 84 women (60 %) and 56 men (40 %). The control group consisted of 67 patients with diverticular colon disease (DCD) without DM 2. Patients who complained of abdominal pain, flatulence, abnormal stool, abdominal discomfort underwent a hydrogen breath test with lactulose to establish bacterial overgrowth syndrome (SIBO) and colonoscopy. Patients with diabetes mellitus, in whom DCD was found and patients in the control group, in the presence of complaints, were prescribed rifaximin (Alpha normix) at a dose of 1200 mg per day for 14 days. After that, they were prescribed a diet with an increase in dietary fiber, and rifaximin at a dose of 800 mg per day for the first 7 days of each month. The patients were followed up for 6 months, patients were recommended to keep a diary of stool control, general condition and abdominal pain.
Results. Diverticular colon disease in patients with type 2 diabetes occurs with a frequency similar to that in the general population. DCD in DM 2 correlates with age and occurs mainly in patients over 55 years old, both in men and women. Most often, diverticulars are localized in the left half of the large bowel. Complaints of abdominal pain and stool disturbance in these patients are combined with SIBO, which is more intense in patients with DCD and DM 2.
Conclusions. It is advisable to use repeated courses of rifaximin 1200 mg per day for 2 weeks for the treatment of DCD in DM 2. When carrying out maintenance treatment, it may be advisable to increase the duration of rifaximin 800 mg per day from 7 to 10 first days of the month in combination with a diet enriched with dietary fiber.
Analisis Perbaikan Kualitas Produk Carton Box di PT XYZ Dengan Metode DMAIC dan FMEA
Authors: Rahman Arif , Perdana Surya
Published: April 2021

PT XYZ merupakan perusahaan manufaktur yang bergerak dalam bidang pembuatan carton box berbagai jenis produk kemasan untuk industri. Perusahaan ini melakukan produksi sesuai dengan pesanan. Selama melakukan proses produksi perusahaan ini mengalami permasalaah berupa cacat produk, banyak produk yang dihasilkan tidak sesuai dengan spesifikasi dan harapan pelanggan. Tujuan penelitian ini adalah untuk mengidentifikasi tingkat kecacatan yang dominan, menganalisis faktor penyebab kecacatan, serta membuat usulan perbaikan guna peningkatan kualitas produk carton box. Analisis data dalam penelitian ini menggunakan metode DMAIC (Define, Measure, Analyze, Improve dan Control) dan Failure Modes Effect Analysis (FMEA). Berdasarkan hasil identifikasi diperoleh kecacatan yang paling dominan terjadi pada proses produksi carton box adalah cacat cetakan gambar yaitu sebanyak 50,1 % dari total kecacatan yaitu sebanyak 137.361 pcs. Hasil analisis FMEA menunjukkan komponen paling besar dengan nilai RPN sebesar 280 cacat produk disebabkan oleh faktor manusia. Usulan perbaikan yang disarankan kepada perusahaan yaitu dengan memperketat pengawasan selama proses produksi agar produk carton box sesuai dengan standar, serta dilakukan pelatihan kepada operator.
ТЕРАПЕВТИЧНА ЕФЕКТИВНІСТЬ СУЧАСНИХ АНТИГЕЛЬМІНТИКІВ ЗА ТРИХОСТРОНГІЛЬОЗУ ГУСЕЙ
Authors: Стародуб Є. С.
Published: April 2021

Розширення асортименту продуктів птахівництва має істотне значення для поліпшення поста-чання населення високоякісними продуктами харчування. Одним із джерел дієтичних видів цієї про-дукції є гусівництво. Серед важливих факторів, що впливають на продуктивні якості, захисні меха-нізми птиці, а також ефективність ведення галузі, є забезпечення ветеринарного благополуччя пта-хівничих господарств щодо паразитарних захворювань, зокрема й трихостронгільозу. Метою досліджень було з’ясувати антигельмінтну ефективність препаратів різних хімічних груп у боротьбі з трихостронгільозом гусей. Проведено експериментальне випробування протигельмінтозних препа-ратів вітчизняного виробництва: фензолу 22 % (ДР – фенбендазол), бровадазолу плюс (ДР – піпера-зину адипінат, фенбендазол), левамізолу-80 (ДР – левамізолу гідрохлорид), універму (ДР – аверсек-тин С), піперазину 45 % (ДР – піперазину адипінат). Основними показниками дії антигельмінтиків були екстенсефективність та інтенсефективність. За результатами проведених копроовоскопічних досліджень гусей дослідних та контрольної груп встановлено, що найбільш ефективними антигель-мінтними засобами в боротьбі з трихостронгільозом у гусей виявилися бровадазол плюс, левамізол-80 та універм, де на 14-у добу експерименту показники екстенс- та інтенсефективності сягали 100 %. Водночас препарати левамізол-80 та універм виявили 100 % ефективність вже на 3 добу дос-ліду, а ефективність препарату бровадазол плюс на 3-ю добу становила 75,0 та 71,55 % відповідно. Препарати фензол 22 % та піперазин 45 % виявилися менш ефективними за трихостронгільозу гу-сей. Показники екстенс- та інтенсефективності фензолу 22 % на 3 добу досліду відповідно станови-ли 25 та 71,55 %, на 7-у добу – 75 та 76,39 %, на 14-у добу – 75 та 83,35 %. Показники ефективнос-ті піперазину 45 % відповідно становили на 3-ю добу досліду – 12,5 та 60,99 %, на 7-у добу – 37,5 та 63,95 %, на 14-у добу – 62,5 та 77,4 %, що свідчить про недостатню антигельмінтну дію цього пре-парату. Отримані дані дають змогу рекомендувати препарати бровадазол плюс, левамізол-80 та універм для ефективної боротьби та профілактики трихостронгільозу в гусей.
ДОСЛІДЖЕННЯ РУХУ ЗЕРНОВОГО МАТЕРІАЛУ ПО ЛОТКАМ ГРАВІТАЦІЙНОЇ УСТАНОВКИ
Authors: Арендаренко В. М. , Самойленко Т. В. , Іванов О. М.
Published: April 2021

На елеваторних підприємствах широко використовують різні технологічні операції. До них від-носяться такі операції, як сортування, сепарація, сушіння, транспортування і завантаження силосів зерном. Для раціонального використання цих та інших процесів необхідно враховувати можливості взаємодії зернин між собою і робочими органами машин. Така взаємодія залежить від характеру руху зернового матеріалу як по поверхням робочих органів відповідного обладнання, так і у пристро-ях для виконання допоміжних операцій, пов’язаних із транспортуванням зерна до завантажувальних отворів силосів, та саме завантаження. Недостатнє врахування особливостей руху зернових пото-ків може призвести до порушення технологічних режимів функціювання елеватора і, як наслідок, погіршується якість зернової продукції, яка зберігається в силосах. Технологічний процес заванта-ження силосів зерновим матеріалом з використанням відкритих спіральних завантажувачів відбува-ється в режимі швидкого гравітаційного руху. Принциповою особливістю такого роду руху є наяв-ність умов швидкого зсуву зернин у зерновому шарі. В результаті такого руху зернини суттєво при-швидшуються і хаотично переміщуються. Метою роботи було виявити структурно-кінематичні характеристики гравітаційних потоків в установці з дискретно змінними кутами нахилу розгінного і гальмівного лотків. Основними завданнями роботи є лабораторне дослідження руху насіння пшени-ці, кукурудзи та соняшнику в U-подібних лотках для того, щоб установити фактичний час руху зер-нового матеріалу як у розгінному, так і в гальмівному лотках. Лотки виготовлені зі сталевого про-кату, мають однакову довжину та шорсткість. Такі дослідження з використанням гравітаційної установки необхідні для виявлення темпу розгону і гальмування сипкого зернового матеріалу стан-дартної вологості. Встановлено, що для ефективної роботи гравітаційної установки необхідно, щоб кут нахилу розгінного лотка був набагато більшим від кута природного відкосу зернового матеріалу. Тоді як кут нахилу гальмівного лотка повинен бути в 1,22 раза більшим від кута природного відкосу зерна. Таке співвідношення кутів дає можливість отримати рух зернового матеріалу в гальмівному лотку практично з постійною лінійною швидкістю без різкого збільшення маси і об’єму зернового вантажу на цій ділянці.
Prosodic effects on pronoun interpretation in Italian
Authors: White Lydia , Goad Heather , Su Jiajia , Smeets Liz , Mortazavinia Marzieh , Garcia Guilherme Duarte , Guzzo Natália Brambatti
Published: April 2021

In this paper we offer a prosodic account of some well-known L2 findings relating to discourse requirements on pronouns in null subject languages like Italian. Discourse plays a role in determining when a null or overt pronoun in acceptable: in biclausal sentences, null subjects are strongly preferred when the antecedent is the subject in another clause (-topic shift). Overt subjects, in contrast, imply a change of topic and a preference for non-subject antecedents. Carminati (2002) expresses this as the Position of Antecedent Hypothesis (PAH), a processing constraint whereby null pronouns prefer antecedents in Spec IP whereas overt pronouns prefer their antecedents to be elsewhere. Previous methodology used tasks where participants made judgments based on sentences they read to themselves, making it impossible to determine what prosody had been adopted. Our results suggest that there are prosodic effects on pronoun interpretation; hence, prosodic factors should be taken into consideration in future experiments.
Weight effects on stress: lexicon and grammar
Authors: Garcia Guilherme D.
Published: April 2021

This thesis examines weight effects on stress and proposes a probabilistic approach based on the notion that weight is gradient, not categorical. Arguments for this proposal are divided into three main chapters, which examine and statistically model weight in the lexicon (Chapter 1), weight in the grammar (Chapter 2), and the interaction of weight and footing (Chapter 3). The statistical analyses in Chapters 2 and 3 also discuss how our linguistic expectations regarding weight effects can be incorporated in statistical models through the use of mildly informative priors, and to what extent the fit of such models compare with that of models based on non-informative priors.
Three dimensional shock induced separated flow
Authors: Bhardwaj Sourabh , Vamsi Kakumani Hemanth Chandra , Rengaran Sriram
Published: April 2021

Supersonic flow over 3-dimensional bodies protruding out of the turbulent boundary layer was investigated by means of experiments and numerical computations. A parametric study was performed by varying the shape and dimensions of the protuberance, as well as the freestream Mach number (1.5, 2, 2.5, 2.89, 3.5). Surface streak line visualization, surface pressure measurements, and time-resolved schlieren visualization were employed along with RANS computations to elicit the complex flow features such as separation line, shock pattern, and the horseshoe vortex which greatly influences the flow dynamics in the separated region. The rise in surface pressure at mid-span due to separation (plateau pressure) was dependent only on the incoming flow parameters, and independent of protuberance geometry. The 2-dimensional free interaction theory, applied for normal shock-induced separation, closely predicts the mid-span plateau pressure. Although protuberances are of varying shapes and dimensions, the inviscid bowshock (obtained from Euler computations) provided generalized scales, whose effects on shock boundary layer interactions are analyzed. The radius of curvature of the inviscid shock on the wall plane at the nose, which is theoretically related to the local second derivative (along the shock)of pressure jump, was found to be a determining parameter of mid-span separation length (𝐿sep). Since the spanwise distance of the sonic point on the inviscid shock was found to be strongly correlated to its nose radius of curvature, it follows that the strong portion of the inviscid bowshock fixes the mid-span separation location. These observations concerning mid-span plateau pressure, and the role of strong shock portion in fixing mid-span separation, suggest that the 𝐿sep shall be predicted from a modification of the scaling laws for the length of plateau pressure region in 2-dimensional shock boundary layer interaction, with the inclusion of spanwise relieving effect. A correlation is obtained relating the 𝐿sep with various incoming flow parameters and inviscid shock nose radius. The mid-span vortex core position was found to be linearly related to the 𝐿sep. The radius of curvature of the separation shock is, however, found to be influenced by the entire inviscid shock, including the weak portion.
PENGARUH EKOWISATA BERBASIS MASYARAKAT TERHADAP PERUBAHAN KONDISI EKOLOGI, SOSIAL, DAN EKONOMI
Authors: Yapanto Lis M
Published: April 2021

Indonesia memiliki potensi keindahan alm dan kekayaan budaya yang bernilai tinggi dalam pasar indutri ekowisata. potensi alam tersebut dapat berupa sumberdaya alam hayati dan ekosistemnya, keanekkaragaman flora, fauna dan gejala alam dengan keindahan pemandangan yang masih alami. Untuk kebudayaan, Indonesia memiliki sistem relige, kesenian, bahasa daerah, ritus kebudayaan, pengetahuan, dan organisasi social. Berdasrkan laporan World Travel Tourins Council (WTTC) Tahun 2002 pertumbuhan ekowisata rata-rata sebesar 10 persen pertahun . angka tersebut lebih tinggi dibandingkan pertumbuhan rata-rata per tahun untuk parawisata pada umumnya yaitu sebesar 4.6 persen pertahun. Sebagai bentuk wisata, ekowisata mempunyai kekhususan tersendiri yaitu mengedepankan konservasi lingkungan, pendidikan, lingkungan, kesejahteraan penduduk local, dan menghargai budaya local, sehingga ekowisata banyak di minati wisatawan.
Differential expression of dystrophin in cancers of the breast.
Authors: Mamoor Shahan
Published: April 2021

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding dystrophin, DMD, when comparing primary tumors of the breast to the tissue of origin, the normal breast. DMD was also differentially expressed in the tumor cells of patients with triple negative breast cancer. DMD mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of DMD in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. DMD may be of relevance to initiation, maintenance or progression of cancers of the female breast.
Attentional Networks in Co-occurring Generalized Anxiety Disorder and Major Depression Disorder: Towards a Staging Approach to the Executive Control Deficits
Authors: Coussement Charlotte , De Longueville Xavier , Heeren Alexandre
Published: April 2021

Introduction. Major Depression Disorder (MDD) and Generalized Anxiety Disorder (GAD) often co-occur, but the neurocognitive mechanisms of this co-occurrence remain unknown. Prominent views have pointed to attentional processes as potent mechanisms at play in MDD and GAD, respectively. Yet uncertainty remains regarding the very nature of attentional impairments in patients with co-occurring MDD and GAD.Methods. Inspired by contemporary models of attentional networks, we compared the three main attentional networks, namely the orienting, alerting, and executive networks of the Attention Network Task, in four groups of patients with, respectively, co-occurring DSM-5 MDD and GAD (n = 30), DSM-5 MDD only (n = 30), DSM-5 GAD only (n = 30), or free from any DSM-5 diagnosis (n = 30). To capture the multivariate nature of our data, we examined between-group differences in the attentional networks through a multivariate analysis of variance.Results. Patients with co-occurring MDD and GAD exhibited more severe impairments in the executive control network than those with only one of the disorders. Although patients with MDD or GAD solely did not differ in attentional impairments, both groups showed significantly more impairments in the executive control network than those without either MDD and GAD (all Bonferonni-corrected post-hoc ps < .05).Conclusions. Our findings align with a longstanding staging approach to comorbidity whereby, via synergistic effects, co-occurring disorders may produce more damages than the sum of each disorder. Here, for the first time, we extended this approach to the executive network of attention in the context of the co-occurrence between MDD and GAD.
A Procedure for the Assessment of Individual Differences in Relational Discrimination Behavior in the Pigeon (Columba livia)
Authors: Flaim Mary , Blaisdell Aaron
Published: April 2021

Raven’s progressive matrices (RPM) is a nonverbal intelligence test that examines abstract reasoning by asking subjects to correctly complete a stimulus matrix where transformations between stimuli in the matrix follow one or more relational rules. While this test has been used since 1936, and has been modified to accommodate a variety of humans, this is the first adaptation for non-human animals. We trained pigeons on a task in which the complexity of the rules could increase progressively. Pigeons initially were trained on one rule, and if discrimination reached criterion performance, were tested on novel exemplars to assess relational control. After learning one rule, some pigeons were trained on a second rule, followed by transfer tests. We chose pigeons because of their previous success in abstract and relational rule learning. Pigeons varied in how many rules could be learned and in how well they could transfer learning to novel images, indicating that this test can measure individual differences in learning abstract properties such as stimulus relations. One pigeon successfully learned and transferred two relational rules, and was tested on a matrix combining both rules together. In the future, our modified RPM procedure could be used to investigate abstract reasoning across species.
Efficacy of Topical 5% 5-Fluorouracil and 0.05% Tretinoin and Electrosurgery in the Treatment of Plane Warts: A Randomized Controlled Comparative Trial
Authors: Singh Rashmi , Pandey Shyam Sundar
Published: April 2021

Human papilloma virus (HPV) is capable of causing varieties of dermatological conditions differing in morphology, histopathology and site of occurrence. Plane wart is one of the morphological varients accounting for approximately one fifth of HPV lesions. Treatment of plane warts is difficult and recurrence quite common .The objective of our study is to compare the efficacy and safety of 5% 5 –fluorouracil (5 FU),0.5% tretinoin and electrosurgery in the treatment of plane wart. Seventy five patients 38 males and 37 females were included in this randomized controlled comparative  trial .Patients were age and sex matched and divided into three groups, GROUP A : Patients treated with 5% 5-Fluorouracil ,GROUP B:Patients treated with 0.5% tretinoin and GROUP C : Patients treated with electrodessication .While topical treatments were applied once nightly for 4 weeks(5% 5-fluorouracil for four hours and tretinoin overnight), radiodessication was done at first visit only.Result and conclusion:While radiofrequency showed faster results , results were more consistent with least recurrence in 5-FU and fair recurrence with .05% tretinoin.
The Challenges of COVID-19 in Medical Education in Nepal
Authors: Paudel Vikash , Neupane Saraswoti
Published: April 2021

The Coronavirus Disease-2019 (COVID-19) pandemic has caused an unparalleled disruption in all forms of scientific learning process including medical education. It has presented a challenge for scientists, educators, and students.Widespread interruptions to medical education, scientific discussions, conference, and seminars have also been seen at times of major conflicts and pandemics in the past as well, which resulted in major changes in medical curriculum.  This editorial discusses the medical education and how COVID-19 has affected medical education in Nepal. Besides, it also explores the potential implications of COVID-19 for the future of medical education.