bluuebunny/crossref_metadata_2025 huggingface dataset:
TINGKAT PENGEMBALIAN INVESTASI PENDIDIKAN PADA LULUSAN FAKULTAS EKONOMI DAN MANAJEMEN (Studi Kasus Lulusan yang Bekerja pada Sektor Formal)
Authors: Gusparima Hilma , Darmawan Refianto Damai , Kartika Lindawati
Published: December 2022

Pengembalian investasi pendidikan di Indonesia menunjukkan angka yang konsisten dan semakin meningkat untuk jenjang pendidikan yang semakin tinggi. Namun jika melihat data, Angka Partisipasi Kasar (APK) di Indonesia mengalami penurunan pada jenjang pendidikan. Sehingga tujuan penelitian ini adalah untuk mengetahui hasil Return on Higher Education Investment (ROHEI) dan kelayakannya pada lulusan Fakultas Ekonomi dan Manajemen IPB sebagai perguruan tinggi negeri di wilayah Jabodetabek.  Jenis data yang digunakan dalam penelitian adalah data kuantitatif dan kualitatif melalui data primer dan sekunder. Metode penentuan dan penarikan sampel yang digunakan adalah nonprobability sampling dan purposive sampling. Jumlah sampel dalam penelitian ini sebanyak 150 orang. Metode analisis yang digunakan adalah analisis deskriptif dan pengembalian investasi. Analisis deskriptif digunakan untuk mengolah data pada karakteristik responden. Adapun analisis pengembalian investasi berupa benefit cost ratio (BCR), rate of return (ROR), cost benefit analysis (CBA), Payback Period (PP), net present value (NPV), dan internal rate of return (IRR) serta analisis loyalitas lulusan menggunakan net promoter score (NPS). Hasil penelitian ini menunjukkan, bahwa kelayakan investasi pendidikan dari gaji responden dinyatakan layak namun hasil penghitungan terkait nilai manfaat berdasarkan tabungan dinyatakan tidak layak. Loyalitas responden terhadap Fakultas Ekonomi dan Manajemen mayoritas berada dalam kategori passive. Kata Kunci: Investasi, Lulusan, Pendapatan Pendidikan, ROHEI, Tabungan
PRINCIPALES NOVEDADES EN LA LEGISLACIÓN SOCIETARIA COMO CONSECUENCIA DE LA LEY CREA Y CRECE, Y LA FUTURA APROBACIÓN DE LOS PROYECTOS DE LEY DE STARTUPS, Y DE EFICIENCIA DIGITAL DEL SERVICIO PÚBLICO DE JUSTICIA
Authors: Benítez García Rufino
Published: December 2022

En el presente artículo destacamos las principales modificaciones en la Ley de Sociedades de Capital que incorpora la Ley de Creación y Crecimiento de Empresas, y las que pueden traer consigo los Proyectos de Ley de Startups; y de Eficiencia Digital al Servicio de la Administración de Justicia, destinadas a impulsar el emprendimiento, facilitar la fundación de sociedades y reducir los obstáculos y desincentivos regulatorios para ello, todo ello de acuerdo con los objetivos propios de la UE prefijados en la importante Directiva (UE) 2019/1151, de “Digitalización de Sociedades”, en el marco de un mundo globalizado y digitalizado.
Evaluation of the Autof ms1000 mass spectrometry for rapid clinical identification of filamentous fungi
Authors: Ao Keping , Li Xiaohan , Zhang Weili , Chen Zhixing , Liu Ya , Shu Ling , Xiao Yuling , Wu Siying , Xie Yi , Kang Mei
Published: December 2022

Background
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized microbial identification; however, there is a paucity of data on its performance characteristics to identify filamentous fungi. The objective of our study was to evaluate the accuracy of the Autof ms1000 mass spectrometry for filamentous fungi identification in the clinical microbiology laboratory.
Results
Among 95.28% (101/106) that were identified using Autof ms1000 systems at Genus/Species, 76.41% (81/106) were correctly identified at the species level. In addition, a new rapid formic acid extraction method with simple pretreatment for filamentous fungi was developed to save time and obtain accurate results.
Conclusions
The Autof ms1000 mass spectrometer showed to be a useful instrument for filamentous fungi identification. Nevertheless, up-gradation of the database is recommended for the correct identification of rare strains.
Synthesis of Vitamin D Conjugated Calcium Carbonate Nanoparticles and Their Application on Selected Cell Lines
Authors: Shaukat Khazaima , Riaz Naveeda , Manzoor Sobia , Urooj Sidra , Fatima Moaiz
Published: December 2022

Cancer is a worldwide conundrum and the leading cause of death. Drug delivery to cancer cells has been changed thanks to nanotechnology. In this study, calcium carbonate nanoparticles were used to provide Vitamin D to the breast cancer cell line MCF-7. The nanoparticles that are used, were prepared by using binary solvents as precipitates and swirling them continuously with a magnetic stirrer. FTIR and XRD measurements confirmed the production of nanoparticles. SEM analysis revealed that nanoparticles have a spherical morphology. According to a UV-Visible spectrophotometer, calcium carbonated nanoparticles had an encapsulation effectiveness of 80% for vitamin D. At a dosage of 2000g/ml, vitamin D conjugated nanoparticles showed a good cytotoxic activity, reducing the viability percentage of cancer cells by up to 11%. As a result, it was found to be helpful in slowing cancer cell development. The findings showed that CaCO3 nanoparticles can effectively supply vitamin D to cancer cells while also inhibiting cancer cell proliferation.
Putting numbers on timber illegality risk: the case of ipê in Pará
Authors: França Caroline Sartorato Silva , Persson Martin , Carvalho Tomás , Lentini Marco
Published: December 2022

Illegal logging remains widespread across the tropics, causing extensive forest degradation and trade in illegal timber products. By adapting environmentally extended input-output modeling to timber originating from Brazilian native forests, we demonstrate how distinct illegality risks can be mapped and quantified at species-level, across the supply-chain. We focus on high-value ipê from the Amazon state of Pará, a leading producer of timber and contested forest frontier. Data on logging permits and state- and national-level Document of Forest Origin are used to estimate illegality risks due to missing or invalid logging permits, overstated ipê yields, and discrepancies resulting from missing inflows of legal timber. We find that less than one fourth of all ipê volume entering supply-chains between 2009-2019 is risk-free and highlight diversified strategies for laundering of illegal timber are across geographies, information that can be leveraged to improve implementation and enforcement of existing forest regulations.
The International Spinal Cord Injury Pain Basic Data Set (Version 3.0)
Authors: Widerstrom-Noga Eva , Biering-Sørensen Fin , Bryce Thomas , Cardenas Diana , Finnerup Nanna , Jensen Mark , Richards John Scott , Rosner Jan , Taylor Julian
Published: December 2022

Study design: Expert opinion, feedback, revisions, and final consensus.
Objectives: To update the International Spinal Cord Injury Pain Basic Data Set (ISCIPBDS version 2.0) and incorporate suggestions from the SCI pain clinical and research community with respect to overall utility.
Setting: International
Methods: The ISCIPBDS working group evaluated these suggestions and made modifications. The revised ISCIPBDS (Version 3.0) was then reviewed by members of the International SCI Data Sets Committee, the American Spinal Injury Association (ASIA) Board, the International Spinal Cord Society (ISCoS) Executive and Scientific Committees, individual reviewers and societies, and posted on the ASIA and ISCoS websites for one month to elicit comments before final approval by ASIA and ISCoS.
Results: The ISCIPBDS (Version 3.0) was updated in order to make the dataset more flexible and useful: 1. The assessment can be based on the patient’s perception of several of his/her “worst” pain(s) or based on the International SCI Pain (ISCIP) Classification-defined or other pain types, depending on the specific research questions or clinical needs. 2. Pain interference should usually be rated for overall pain but may also be used for specific pain problems if needed. 3. An optional pain drawing was added to complement the check box documentation of pain location. 4. Data categories consistent with the Extended Pain Dataset list of current treatments were added. 5. Several new training cases were added.
Allele-specific hormone dynamics in highly transgressive F2 biomass segregants in sugarcane (Saccharum species)
Authors: Ain Noor-ul-Ain , Zhang Xingtan , Habiba Habiba , Lin Jishan , Ming Ray
Published: December 2022

Background
Sugarcane is a competitive candidate to serve as feedstock for biofuel production worldwide. Plant hormones play an important role in growth and development and regulate biomass yield. Understanding hormonal dynamics and their regulation is critical for increasing sugarcane biomass. To enhance our understanding of biological pathways involved in biomass accumulation, transcriptome analysis of highly segregating F2 introgression hybrids derived from the cross of Saccharum officinarum'LA Purple' and wild S. robustum 'MOL5829' was performed in this study. Recently sequenced information rich allele-specific genome of S. officinarumserved as a reference to identify differentially regulated genes in two groups of extreme segregants of biomass.
Results
Overall, 8059 differentially expressed genes (log2FC > 2) were grouped into distinct categories viz. Gene Models (21.5%) (GMs), alleles (68%), paralogs (10%) and tandemly duplicated genes (0.14%). KEGG analysis showed enrichment of auxin (IAA), jasmonic acid (JA) and abscisic acid (ABA) related pathways and interesting regulatory roles of three hormone repressor gene families (Aux/IAA, PP2C, and JAZ) of IAA, ABA and JA, respectively. Signaling pathways of these hormones indicated down-regulation of AUX/IAA and PP2C and up-regulation of JAZ repressor genes in high biomass group controlling the expression of downstream growth and development genes. Endogenous hormone levels show higher IAA and ABA contents in high biomass and vice versa for JA. Weighted co-expression network analysis (WGCNA) demonstrated high connectivity between identified hormones related key genes and cell wall structural genes in high biomass genotypes. FPKM and RT-PCR based expression analysis showed the up-regulation of carbohydrate structural genes and down regulation of inflorescence and senescence related genes, which indicated an extended vegetative growth phase in high biomass genotypes. Furthermore, high biomass group displayed modulated regulation of hormones which was achieved by the cumulative expression of Gene Models (GMs), dominant alleles, paralogs, and tandemly duplicated genes.
Conclusion
Our data revealed that activators and repressors of disparate hormone (IAA, JA, and ABA) signaling pathways are the points of hormone crosstalk in contrasting biomass F2 segregants and could be applied for engineering high biomass acquiring varieties.
Comparative Evaluation of RBPT, I-ELISA, and CFT for the Diagnosis of Brucellosis and PCR Detection of Brucella species from Ethiopian Sheep, Goats, and Cattle sera
Authors: Legesse Abinet , Mekuriaw Aregitu , Gelaye Esayas , Abayneh Takele , Getachew Belayneh , Weldemedhin Wubet , Tesgera Takele , Deresse Getaw , Birhanu Kenaw
Published: December 2022

Method: Brucella is an intracellular bacterium that affects both animals and humans. The aim of this study was to compare brucellosis diagnostic methods such as RBPT, I-ELISA, CFT and PCR detection of Brucella species. A total of (552) Sheep, (1345) Goats, and (420) Cattle sera samples were collected with no history of vaccination from brucellosis reported regions of Ethiopia. All sera samples were subjected to comparative serological assays. Post- cross tabulation, sensitivity and specificity were determined using Receiver Operating Characteristics (ROC) curve analyses software. Fifty-four sero-positive sera samples were also subjected to PCR amplification targeting Brucella Genus-specific, as well as B. abortus, and B. melitensis species specific primers.
Results: Among 2317 sera samples subjected to comparative serological diagnostic tests (RBPT, I-ELISA and CFT), 189 (8.16 %) for RBPT, 191 (8.24 %) for I-ELISA and 48 (2.07 %) on CFT were found to be positive. Sensitivity on RBPT was 100 % with (95%) in Sheep, 100% (95%) Goats and 74% (95%) Cattle. Specificity on RBT was 98.69% (95%), 99.28% (95%), 100 (95%) in Sheep, Goats and Cattle, respectively. Sensitivity on CFT was 4% with (95) in Sheep 9.65 (95%) Goats and 72 (95%) Cattle. Specificity on CFT was 100 % (95%) for each Sheep, Goats and Cattle. In PCR amplified product analyses, a 223bp in Brucella genus-specific and 156bp B.abortus species specific were detected from all study animals. However, B. melitensis was not detected in all sera samples.
Conclusion: In this study Indirect-ELISA was found to be the most sensitive and specific test. RBPT was also sensitive enough to detect all Brucellosis-infected Sheep and Goats. However, this test showed false positive in Sheep and Goats and false negative results in cattle. Therefore, RBT should be complemented with ELISA to solve problems associated with sensitivity and specificity of RBT. PCR assay employed in this study confirmed the presence of B. abortus in small and large ruminants consistent to the study sites. This study is the first report on the detection of B.abortus on small ruminants’ serum in Ethiopia. We could detect B. abortus in non-preferred hosts. The findings suggest further extensive works are required to determine the genetic diversity of Brucella species and understand their molecular epidemiology at national level to design cost effective prevention and control methods.
Can digital finance alleviate the resource curse? Evidence from Resource-based Cities in China
Authors: Huang Xinpeng
Published: December 2022

This paper investigates how digital finance alleviates the resource curse effect from resource-based cities in China. This paper selects the data from 88 resource-based cities in China from 2011 to 2019 to construct the econometric model test hypothesis. The results show that: (1) Resource curse does exist in Chinese resource-based cities. (2) Digital finance can alleviate the resource curse of resource-based cities in China, and this effect has two significant thresholds. (3) The heterogeneity test results show that digital finance's mitigation effect on the resource curse significantly differs in cities with different environmental regulation intensities and resource abundance. (4) Using the implementation of the broadband China strategy as the proxy variable of digital finance for the robustness test, the above conclusions are still robust. This paper considers the impact of digital upgrading on the financial industry and further studies the mitigation effect of digital finance on the resource curse. It provides a new perspective to study the recent changes in traditional issues in the digital era.
Unconventional quantum criticality in a non-Hermitian extended Kitaev chain
Authors: S Rahul , Roy Nilanjan , R Ranjith Kumar , Kartik Y R , Sarkar Sujit
Published: December 2022

We investigate the nature of quantum criticality and topological phase transitions near the critical lines obtained for the extended Kitaev chain with next nearest neighbor couplings and non-Hermitian chemical potential. We surprisingly find multiple gap-less points, the locations of which in the momentum space can change along the critical line unlike the Hermitian counterpart. The interesting simultaneous occurrences of vanishing and sign flipping behavior by real and imaginary components, respectively of the lowest excitation is observed near the topological phase transition. Introduction of non-Hermitian factor leads to vanishing of a critical line and hence, reduced number of multi-critical points as compared to the Hermitian case. The critical exponents obtained for the multi-critical and bi-critical points show a very distinct behavior from the Hermitian case. Interestingly, we further observe violation of Lorentz invariance throughout the criticality in our non-Hermitian model.
Expectations of nursing home residents and their family members during the COVID-19 epidemic: A qualitative study
Authors: Cui Baojuan , Li Hui , Cheng Yan , Wang Jinmei , Sun Qiangsan , Jia Yuxiu
Published: December 2022

Background
COVID-19 has spread worldwide. Older people are at the greatest risk of contracting and dying from the virus. Nursing homes are densely populated places for older adults who are generally vulnerable and at high-risk. Although Chinese nursing homes have been trying to protect their residents, the needs and expectations of the residents and their families have been ignored. The aim of this study was to explore and better understand the expectations of nursing home residents and their family members during the COVID-19 epidemic in China.
Methods
Data was collected via face-to-face semi-structured interviews with nursing home residents and focus group online interviews with family members between June 2021 and February 2022. Data analysis followed inductive content analysis.
Results
16 residents and 24 family members were interviewed. Four themes with 11 sub-themes were identified from the descriptions of participants. Their expectations were mainly focus on prevention and control measures for COVID-19, medical capacity of nursing homes, health education and expectations for some aged care policies.
Conclusions
In the face of concerns about the impact of COVID-19 on nursing homes, we sought to bring firsthand perspectives to the forefront by interviewing residents and their family members about their expectations to address this issue. Our findings provide important areas on which should be focused and may improve the sense of gain, happiness, and security of nursing home residents during the COVID-19 epidemic.
A Comprehensive Integrated Dataset on Brazilian Health Facilities: from 2005 to 2021
Authors: Salles Rebecca , Ribeiro Victor de Paula Dornellas , Gritz Raquel , Cardoso Carlos Leonardo Souza , Paixão Balthazar , Carraro Lucas , Cruz Sérgio Ricardo de Borba , Kreischer Vinicius , Bonifácio Carmen Lúcia Corrêa , Saldanha Raphael de Freitas , Souto Gabriel , Miloski Matheus , Zirondi Leandro , Alencar Gizelton Pereira , Alves Ariane Camilo Pinheiro , Neto Nelson Niero , Lima Jefferson da Costa , Pedroso Marcel , Alves Ronaldo Fernandes Santos , Boccolini Patricia de Moraes Mello , Boccolini Cristiano Siqueira
Published: December 2022

Objectives
The National Registry of Healthcare Facilities is a system with the registry of every healthcare facility in Brazil with information on the capacity building and healthcare workforce regarding its public or private nature. Despite being publicly available, it can only be accessed in separated disjoint tables, with different primary units of analysis. The objective is to offer an interoperable dataset containing monthly data from 2005 to 2021 with information on healthcare facilities, including their physical and human resources, services and teams, enriched with municipal information.
Data description
Database with historical data and geographic information for each health facility in Brazil. It is composed by 5 distinct tables, organized according to combinations of time, space, and types of resources, services and teams. This database opens up a range of possibilities for research topics, from case studies in a single health facility and period, analysis of a group of health facilities with characteristics of interest, to a broader study using the entire dataset and aggregated data by municipality. Furthermore, the fact that there is a row for each health facility/month/year facilitates the integration with other datasets from the Brazilian healthcare system. In addition to being a potential object of study in the health area, the dataset is also convenient in data science, especially for studies focused on time series.
On the role of history-dependent adsorbate distribution and metastable states in switchable mesoporous metal-organic frameworks
Authors: Walenszus Francesco , Bon Volodymyr , Evans Jack D. , Krause Simon , Getzschmann Jürgen , Kaskel Stefan , Dvoyashkin Muslim
Published: December 2022

A unique feature of metal-organic frameworks (MOFs) in contrast to rigid nanoporous materials is their structural switchabilty offering a wide range of functionality for sustainable energy storage, separation and sensing applications. This has initiated a series of experimental and theoretical studies predominantly aiming at understanding the thermodynamic conditions to transform and release gas, but the nature of sorption-induced switching transitions is still not fully understood yet. Here we report experimental evidence for fluid metastability and history-dependent states during sorption trigerring the structural change of the framework and leading to a counterintuitive phenomenon of negative gas adsorption (NGA) in flexible MOFs. Preparation of two isoreticular MOFs differing by structural flexibility and performing direct in situ diffusion studies aided by in situ X-ray diffraction, scanning electron microscopy and computational modelling, allowed assessment of n-butane molecular dynamics, phase state, and the framework response and obtaining microscopic picture for each step of the soprtion process.
SARS-CoV-2 viremia but not respiratory viral load is associated with ventilator complications
Authors: Chen Lingye , Olson Lyra B. , Naqvi Ibtehaj A. , Sullenger Bruce A. , Nair Smita K , Que Loretta G. , Denny Thomas N. , Kraft Bryan D.
Published: December 2022

COVID-19 can cause acute respiratory distress syndrome (ARDS) associated with high morbidity and mortality. Previous studies have shown an association between plasma viral load (VL) of severe acute respiratory distress (SARS-Cov2) and disease severity. This study is one of the first to measure endotracheal aspirate (ETA) VL in addition to plasma VL in patients admitted to the medical intensive care unit with COVID-19. Viral load from both plasma and ETA decreased over time. Subjects with high plasma VL experienced a greater number of adverse events, including ventilator-associated pneumonia (VAP), increased number of days on mechanical ventilation, and increased number of days in hospital. There was no association between ETA VL and adverse events.
Knowledge, perception, reasons, and suggested measures for mitigating academic dishonesty among healthcare students in a Nigerian University
Authors: Orok Edidiong , Adeniyi Funmilayo , Williams Tonfamoworio , Dosunmu Oyebode , Ikpe Favour , Orakwe Clifford
Published: December 2022

This study aimed to assess the knowledge, perception, influencing factors as well as suggested strategies to reduce academic dishonesty among healthcare students. A cross-sectional design that employed a self-administered online questionnaire was used to collect data among healthcare students in Afe Babalola University, Ado-Ekiti, Nigeria. Purposive and simple random sampling techniques were used in selecting the respondents. Knowledge was categorised into poor (< 50%), fair (50–69%) and good (≥ 70%) while perception was classified as positive (≥ 50%) and negative (< 50%). Association between student demographics, and perception of academic dishonesty was analysed using Chi-Square and Fisher Exact tests. Differences in knowledge between demographics was analysed using independent sample T-test and One way Analysis of variance. 335 students were enrolled in this study of which 83.3% were female and the mean age of the respondents was 19.33 years. 29.8% and 94.9% of the students showed good knowledge and positive perception of academic dishonesty respectively. There was a significant difference in knowledge based on students’ level of study (p < 0.001) and departments (p < 0.001). Fear of failure (77.0%), social stigma and peer pressure (37.0%) were commonly identified reasons for academic dishonesty among students while strict punishment (18.3%) and proper invigilation (16.2%) were the most suggested strategies (n = 178) to control academic dishonesty among students. Poor to fair knowledge and positive perception towards academic dishonesty was shown by majority of the students. Educational intervention in form of training and proper implementation of suggested strategies is warranted to improve knowledge, reduce misconceptions and ultimately reduce academic dishonest behaviours among students.
The Weinstein transform associated with generalized distributions
Authors: Upadhyay Santosh Kumar , Yadav Sitaram
Published: December 2022

Björck [4], and Hörmander [8], investigated the linear partial differential operators and generalized distributions associated with the Fourier transform by utilizing the convolution properties on the spaces of types Dω(Rn), Eω(Rn), and Sω(Rn). Motivated by above results the present paper examined various properties of the Wein-stein transform over generalized distributions Dω (R+n+1) and other spaces. The convolution properties of generalized distributions associated with the Weinstein transform on space Dω (R+n+1) ) are discussed.
Mathematics Subject Classification (2010). 46F05. 46F10. 46F12. 42A85.
Identification and Experimental Validation of Parkinson’s Disease with Major Depressive Disorder Common Genes
Authors: Wang Huiqing , Dou Shanshan , Gao Wenming , Cheng Baohua , Yan Fuling
Published: December 2022

Parkinson's disease (PD) is the second most common neurodegenerative disease that affects about 10 million people worldwide. Non-motor and motor symptoms usually accompany PD. Major depressive disorder (MDD) is one of the non-motor manifestations of PD it remains unrecognized and undertreated effectively. MDD in PD has complicated pathophysiologies and remains unclear. The study aimed to explore the candidate genes and molecular mechanisms of PD with MDD. PD (GSE6613) and MDD (GSE98793) gene expression profiles were downloaded from Gene Expression Omnibus (GEO). Above all, the data of the two datasets were standardized separately, and differentially expressed genes (DEGs) were obtained by using the Limma package of R. Take the intersection of the two differential genes and remove the genes with inconsistent expression trends. Subsequently, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were investigated to explore the function of the common DEGs. Additionally, the construction of the protein-protein interaction (PPI) network was to search the hub genes, and then the least absolute shrinkage and selection operator (LASSO) regression was used to further identify the key genes. GSE99039 for PD and GSE201332 for MDD were performed to validate the hub genes by the violin plot and receiver operating characteristic (ROC) curve. Last but not least, immune cell dysregulation in PD was investigated by immune cell infiltration. As a result, a total of 45 common genes with the same trend. Functional analysis revealed that they were enriched in neutrophil degranulation, secretory granule membrane, and leukocyte activation. LASSO was performed on 8 candidate hub genes after CytoHubba filtered 14 node genes. Finally, AQP9, SPI1, and RPH3A were validated by GSE99039 and GSE201332. Additionally, the three genes were also detected by the qPCR in vivo model with the same phenomenon. The co-occurrence of PD and MDD can be attributed to AQP9, SPI1, and RPH3A genes. Neutrophils and monocytes infiltration play important roles in the development of PD and MDD. Novel insights may be gained from the findings for the study of mechanisms.
Do the Total Received of Zakat Funds and Total Received of Infak/Alms Funds Affect the Number of Poor Populations? an Evidence from Indonesia
Authors: Sobiyanto Ahmad
Published: December 2022

This research was conducted to find out whether there was any influence from the total receipt of zakat funds and receipt of infaq/alms funds on the number of poor people in Indonesia in 2017-2019. Secondary data comes from the financial reports of the National Amil Zakat Agency or BAZNAS of the Republic of Indonesia and the Central Bureau of Statistics of the Republic of Indonesia for 2017-2021. The results of multiple linear regression indicate that the amount of zakat funds received and the amount of infaq/alms funds received simultaneously has no significant effect on the variable number of poor people in Indonesia. The amount of receipt of zakat funds and the amount of receipt of infaq/alms funds partially have no significant effect on the number of poor people in Indonesia.
Assessment of on-road High Nox Emitters by Using Machine Learning Algorithms for Heavy-duty Vehicles
Authors: KAZAN Filiz , Thiruvengadam Arvind , Besch Marc
Published: December 2022

The aim of this study was to develop a model structure and to train a model based on chassis dynamometer datasets and subsequently use the trained model in conjunction with portable emission measurement system (PEMS) datasets in order to identify vehicles as possible high-NOx emitting vehicles. The long-short term memory (LSTM) model developed based on a single reference vehicle (i.e., Vehicle A) dataset was applied to the entire 12 diesel vehicle PEMS datasets in order to identify high-NOx emitters. The results showed that the vehicles that were manually identified as high emitting vehicles (i.e., control subjects) were also identified by the LSTM model to exceed real-world NOx emissions. Similarly, a random forest (RF) model was developed for a reference CNG vehicle (i.e., Vehicle N) and subsequently applied to 11 CNG vehicles with a 0.2 g/bhp-hr NOx regulation limit using PEMS data in order to identify any possible high NOx emitting vehicles. The results showed that the vehicles that were manually labeled as high emitters were also identified by the RF model to exhibit high real-world NOx emissions beyond any properly working vehicle. The prediction results show that high NOx emitting vehicles had a ratio of predicted versus measured NOx emissions that were lower than unity.
Boundary Lipschitz Regularity and the Hopf Lemma for Fully Nonlinear Elliptic Equations
Authors: Lian Yuanyuan , Zhang Kai
Published: December 2022

In this paper, we study the boundary regularity for viscosity solutions of fully non-linear elliptic equations. We use a unified, simple method to prove that if the domain Ω satisfies the exterior C1,Dini condition at x0 ∈ ∂Ω (see Definition 1.2), the solution is Lipschitz continuous at x0; if Ω satisfies the interior C1,Dini condition at x0 (see Definition 1.4), the Hopf lemma holds at x0. The key idea is that the curved boundaries are regarded as perturbations of a hyperplane. Moreover, we show that the C1,Dini conditions are optimal.
2010 MSC: 35B65, 35J25, 35J60, 35D40
How to adjust the expected waiting time to improve patients' satisfaction？
Authors: Zhang Hui , Ma Wei-Min , Zhu Jing-jing , Wang Li , Guo Zhenjie , Chen xiangtang
Published: December 2022

Background
Long waiting time in hospital leads to patients’ low satisfaction. In addition to reducing the actual waiting time (AWT), we can also improve satisfaction by adjusting the expected waiting time (EWT). Then, what degree should medical institutions adjust patients' EWT to in order to improve patient’s satisfaction more effectively?
Methods
A total of 303 patients who were treated by the same doctor from August 2021 to April 2022 voluntarily participated in this study. The patients were randomly divided into six groups: a control group (n = 45) and five experimental groups (n = 252). Each group answered different questionnaires to explore the impact of different degrees of EWT extension on patient’s satisfaction. Each participant only participated in filling out one questionnaire. 297 valid questionnaires were obtained from the 303 questionnaires given.
Results
The experimental groups had significant differences between the initial EWT (T0) and extended EWT (T1) under the effect of unfavorable information (20.0 [10.0, 30.0] vs. 30.0 [10.0, 50.0], Z = -4.086, P < 0.001). There was no significant difference between sex, age, education level and hospital visit history (χ2 = 3.198, P = 0.270; χ2 = 2.177, P = 0.903; χ2 = 3.988, P = 0.678; χ2 = 3.979, P = 0.264) in extended EWT (T1). Compared with the control group, significant differences were found in patient’s satisfaction when T1 = 80 min (χ2 = 13.511, P = 0.004), T1 = 90 min (χ2 = 12.207, P = 0.007) and T1 = 100 min (χ2 = 12.941, P = 0.005). However, no significant difference was found when T1 = 70 min (χ2 = 7.747, P = 0.052) and T1 = 110 min (χ2 = 4.382, P = 0.223). When T1 = 90 min (T1 = Ta), 69.4% (34/49) of the individuals felt “very satisfied”. This proportion is not only significantly higher than that of the control group (34/ 49 vs. 19/52, χ2 = 10.916, P = 0.001), but also the highest among all groups.
Conclusions
Providing unfavorable information prompts can extend the EWT, but the extension needs to be based on the actual number of patients. Only when the extended EWT is close to the AWT can the patients’ satisfaction level be remarkably improved. Therefore, medical institutions can adjust the EWT of patient’s through information release according to the AWT of hospitals to improve patient’s satisfaction.
Hemispheric asymmetries and brain size: A cross-species meta-regression
Authors: Ocklenburg Sebastian , Basbasse Yasmin El , Ströckens Felix , Müller-Alcazar Anett
Published: December 2022

Hemispheric asymmetries differ considerably across species, but the neurophysiological base of this variation is unclear. It has been suggested that hemispheric asymmetries evolved to bypass interhemispheric conduction delay when performing time critical tasks. This implies that large brains should be more asymmetric. We performed preregistered cross-species meta-regressions with brain mass and neuron number as predictors for limb preferences, a behavioral marker of hemispheric asymmetries. Brain mass and neuron number showed positive associations with rightward limb preferences but negative associations with leftward limb preferences. No significant associations were found for ambilaterality. These results are only partly in line with the idea that conduction delay is the critical factor that drives the evolution of hemispheric asymmetries. They suggest that larger-brained species tend to shift towards more right-lateralized individuals. Therefore, the need for coordination of lateralized responses in social species needs to be considered in the context of the evolution of hemispheric asymmetries.
Purinergic Signaling In Vivo Phenotypic Validation of Adenosine Receptor-Dependent Activity of Non-adenosine Drugs
Authors: Xiao Cuiying , Gavrilova Oksana , Liu Naili , Lewicki Sarah A. , Reitman Marc L. , Jacobson Kenneth A.
Published: December 2022

Some non-adenosinergic drugs are reported to also act through adenosine receptors (ARs). We used mouse hypothermia, which can be induced by agonism at any of the four ARs, as an in vivo screen for adenosinergic effects. An AR contribution was identified when a drug caused hypothermia in wild type mice that was diminished in mice lacking all four ARs (quadruple knockout, QKO). Alternatively, an adenosinergic effect was identified if a drug potentiated adenosine-induced hypothermia. Four drugs (dipyridamole, nimodipine, cilostazol, cyclosporin A) increased the hypothermia caused by adenosine. Dipyridamole and nimodipine probably achieved this by inhibition of adenosine clearance via ENT1. Two drugs (cannabidiol, canrenoate) did not cause hypothermia in wild type mice. Four other drugs (nifedipine, ranolazine, ketamine, ethanol) caused hypothermia, but the hypothermia was unchanged in QKO mice indicating non-adenosinergic mechanisms. Zinc chloride caused hypothermia and hypoactivity; the hypoactivity was blunted in the QKO mice. Interestingly, the antidepressant amitriptyline caused hypothermia in wild type mice that was amplified in the QKO mice. Thus, we have identified adenosine-related effects for some drugs, while other candidates do not affect adenosine signaling by this in vivo assay. The adenosine-modulating drugs could be considered for repurposing based on predicted effects on AR activation.
Learning Control of a Laser-Driven Locomotive Microrobot for Dry Environments
Authors: Yang Zhong , Alqatamin Moath , Sherehiy Andriy , Zhang Ruoshi , Hudibi Mojtaba Al , Chowdhury Sri Sukanta , Popa Dan O.
Published: December 2022

In this paper, we introduce the SerpenBot, a microrobot smaller than 1mm in size, powered by laser energy, and designed to operate in dry environments. The microrobot achieves locomotion on a Si substrate by selective coupling of laser energy between two legs that move the robot forward and steer it. The laser energy coupling mechanism is achieved by selective energy-time irradiation of the microrobot’s body and legs to initiate the gait. Complex multi-physics models developed in our past work are simplified to a differential drive kinematic model that approximates the robot behavior and is used to formulate a deep learning controller that can steer the robot to desired locations on the silicon substrate. Simulations predict the robot position regulation achieved by deep learning of the inverse robot Jacobian. Experimental results are presented confirming that the microrobot can be automatically steered to a goal location.
Economic Giants of the East and Debt Accumulation in Sub Saharan Africa
Authors: Gamette Pius , Avorkpo Eric Atsu , Opoku Alexander
Published: December 2022

This study investigates the level to which Chinese Loan Financiers’ contribute to debt pile up in Sub Sahara Africa countries (SSA). Using a panel data from 45 SSA countries from 2000 to 2017 and adopting the Pooled Ordinary Least Sqaure (OLS) regression method, the findings suggested that credit disbursement from Commercial Development Bank (CDB) and Suppliers Credit to SSA countries each has a significant positive impact on SSA debt accumlation. However, credit from Eximbank has a significant negative impact on debt accumulation in SSA. In terms of sectorial contribution to debt stock, the Envrionmental sector was the highest recipient of Chinese loans compared to Multisector, Food and Unallocated sectors in SSA. The useful implication is that to minimise debt stock in SSA countries, policy makers within the sub region must efficiently take debt miimising decisions after analysing the tradeoff between pressing development needs and the debt accumulation. As an input to existing literature, this study makes available an imperative contribution for deliberations on the relevance of external borrowing and debt accumulation in SSA.
JEL: C23, G51, H6
Fast start-up and enhancement of CANON process for the low-strength wastewater treatment: tactic and action of ultrasonic
Authors: Zhang Li , Luo Di , Huang Diannan , Qian Jie , Ma Xingguan , Zhang Lei , Li Jiaxin , Gao Yunan
Published: December 2022

In this study, the CANON (Completely Autotrophic Nitrogen-removal Over Nitrite) process was successfully started-up inoculate by anammox sludge which was under cold preservation for three-months, and the stable operation of CANON process for low-strength wastewater treatment were achieved through ultrasonic enhancement. In accordance with the optimal parameters determined in batch tests, which controlled (DO=0.3-1.5mg/L, HRT=4.0-12h and pH 7.5±0.3) three critical factors to repressed the NOB (Nitrite-Oxidizing Bacteria). The CANON process was started-up within 15 days. Subsequently, effect of ultrasonic was gradually added to the CANON system to investigate its impact. Results showed that, through ultrasonic (intensity of 0.3 w/cm2, act on time 4 min/d), the NH4 +-N and TN removal efficiency were 95% and 76.7% in the CANON process(~50 mg N.L-1), respectively. The 16S rRNA analysis showed that the abundance of dominanted phylum has remarkablely conversion after ultrasonic enhancement. The relative abundance of AOB were increased form 12.15% to 24.14%. Moreover, the NOB were decreased from 2.97% to 1.64%. The relative abundance of Candidatus brocadia and Candidatus Kuenenia were accounted for 27.07% and 11.52%, respectively. The Nitrosomonas was also enriched to 12.15% significantly. In general, a certain intensity of ultrasonic (intensity of 0.3 w/cm2, act on time 4 min/d) could provides an effective promotion for AOB and suppression for NOB. The results provide technical assistance for the starting-up and stably performance in the mainstream CANON system.
Effect of microencapsulated cocoa intake on muscle recovery, inflammation, and oxidative stress after exercise-induced muscle damage
Authors: Junior Olavo Ramos , Souza Karen , Tavares Isabela Ribeiro Grangeira , de Oliveira Gustavo Vieira , Alvares Thiago Silveira
Published: December 2022

The exercise-induced muscle damage is associated with symptoms such as inflammation, delayed onset muscle soreness and impaired muscle performance. Cocoa polyphenols intake has been suggested to improve muscle recovery due to their antioxidant and anti-inflammatory capacity. However, its bioavailability is challenging. Therefore, food microencapsulation may be an alternative to protect polyphenols, ensuring biological effects. This study aimed to investigate the effect of a single dose of microencapsulated cocoa intake on the changes in muscle damage markers after eccentric exercise. In this randomized, double-blind, crossover design study, fourteen healthy volunteers with previous resistance training experience performed 6 x 10 maximal isokinetic eccentric contractions of the elbow flexors using an isokinetic dynamometer after ingesting 25g of microencapsulated cocoa or placebo. Peak isometric torque was measured by maximal voluntary isometric contractions and pain by visual analogic scale before, 24h, 48h and 72h after damage protocol. Plasma glutathione and malondialdehyde levels were measured using high-performance liquid chromatography, and myoglobin and C-reactive protein were determined by a fluorescence immunoassay analyzer. Significant decreases were seen in peak isometric torque and pain measures from pre to 72h post eccentric exercise. A significant main effect for time was found only for plasma myoglobin at 2h, 48h, and 72h, and 2h for C-reactive protein compared to pre values. No significant time x treatment effects were observed (all p > 0.05). This study demonstrated that microencapsulated cocoa could not improve muscle recovery after eccentric exercise, at least when consumed in a single dose.
Primary ureteroscopy for proximal ureteral stones
Authors: Lazarovich Alon , Shvero Asaf , Zillberman Dorit E , Dotan Zohar , Winkler Harry , Kleinmann Nir
Published: December 2022

Purpose

Primary Ureteroscopy & Laser Lithotripsy is the treatment of choice for distal ureteral stones. However, in cases of proximal ureteral stones some urologists recommend preliminary insertion of a Double J ureteral stent (DJS) and deferred Ureteroscopy. We aim to evaluate the necessity of preliminary DJS insertion in proximal ureteral stones management, by comparing the surgical outcome of patients undergoing primary ureteroscopy and laser lithotripsy for proximal Vs. distal ureteral stones.

Patients and Methods

Medical records of patients who underwent ureteroscopy between January to December 2016 in our institution were reviewed. Data collected included: demographic data, stone size, renal function, intra and post-operative complications, stone free rate (SFR). Patients were divided into 2 groups: Proximal ureteral stones and Distal ureteral stones.

Results

This cohort included 241 patients who underwent ureteroscopy, among them 106 had a proximal ureteral stone. Median age was 51 years. Patients who underwent ureteroscopy for proximal ureteral stone were significantly older: 54.68 vs.49.2 (p = 0.007). The median stone maximal diameter was 7 mm, the proximal ureteral stones were larger with borderline statistical significance (p = 0.07). The complication rate and stone free rate (SFR) was similar among both groups (p = 0.657 and p = 1, respectively). The Prevalence of post procedural DJS insertion was higher among patients who underwent ureteroscopy for proximal ureteral stone: 92.5% Vs. 79.3% (p = 0.004).

Conclusions

Our study concludes that primary ureteroscopy and laser lithotripsy for proximal ureteral stones is a valid and feasible treatment with similar surgical outcome compared to distal ureteral stones. Preliminary DJS insertion seems to be unnecessary.
A comparative analysis on adaptation behavior and failure risk of femurs of different qualities under the effect of direct transfemoral fixations
Authors: Omidvar Armin , Soheilifard Reza , Kowsar Sara
Published: December 2022

Osseointegrated transfemoral prostheses secure the direct attachment of prosthetic limbs. Despite the existence of relevant studies concerning these fixations, the effect of bone quality on their outcome has not been thoroughly investigated. In this study, the finite element (FE) analysis was linked to a bone remodeling algorithm to simulate the bone adaptation process. The 3D models of femurs with average shaft diameters of 24mm, 26mm, and 28mm were created based on computerized tomography (CT) scan images. Three initial densities representing high, moderate, and low-density femurs were also modeled based on the available data in the literature. Eventually, the effect of bone quality was evaluated in terms of bone adaptation and failure risk. The analysis revealed that the dissimilarities in bone quality considerably affect the bone mineral density (BMD) changes and stress distribution in the implantation area. The presence of transfemoral implants increased the interface failure risk at the distal zones for low-quality femurs while decreasing the failure risk at the proximal zones. It was also shown that the chance of fracture and interface failure is lower for dense femurs, and the remodeling process does not significantly affect their failure risk.
Impact of Persistent Organic Pollutants on AIDS progression and all-cause mortality. A longitudinal study in HIV-2 infected individuals in Guinea-Bissau
Authors: Lindman Jacob , Ström Kajsa , Månsson Fredrik , Biague Antonio , Silva Zacarias José da , Esbjörnsson Joakim , Jansson Marianne , Medstrand Patrik , Jakobsson Kristina , Norrgren Hans
Published: December 2022

Background: Persistent organic pollutants (POPs) may be harmful to human health. In a previous study we found high levels of organochlorine (OC) pesticides in an occupational cohort in Guinea-Bissau. We investigated if POP levels in serum were associated with clinical progression to AIDS and mortality in individuals infected with HIV-2, an AIDS-causing virus that is circulating in West Africa.
Methods: We selected HIV-2 infected individuals entering an open prospective cohort of police officers in Guinea-Bissau between 1990 and 1996, who progressed to AIDS within five years after inclusion (progressors, n=30). For comparison, HIV-2 infected individuals without AIDS during at least five years of follow-up were selected (non-progressors, n=52). Biobanked sera were analysed for 22 POPs, including OC pesticides and polychlorinated biphenyls (PCB). Associations of individual POP concentrations with the development of AIDS within 5 years were first evaluated with logistic regression adjusted for age and sex. Cox proportional hazard models adjusting for age and sex were then used to determine associations between POPs and progression to AIDS or all-cause mortality during prolonged follow-up that continued until 2013.
Results: High serum levels of OC pesticides were detected at cohort entry. The development of AIDS was not related to baseline serum POP levels. During prolonged follow-up, 58 individuals developed AIDS (71%) and 53 died (65%). An increased risk for all-cause mortality was observed for beta- hexachlorocyclohexane (HR 1.35, 95%CI 1.01-1,82), p,p´-DDT (HR 1.32, 95%CI 0.99-1.77) and p,p´-DDE (HR 1.34, 95%CI 0.99-1.81). Eight PCBs were also evaluated without any association with development of AIDS or all-cause mortality.
Conclusions: An association was indicated between higher levels of OC pesticides and increased all-cause mortality risk, but not with progression to AIDS among HIV-2 infected individuals in Guinea-Bissau, West Africa. Our results reinforce that public health actions should be considered to minimize exposure to OC pesticides.