bluuebunny/crossref_metadata_2025 huggingface dataset:
Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis
Authors: Abboud Myriam
Published: April 2020

Suboptimal vitamin D status is associated with elevated blood pressure (BP) in children and adolescents. Whether vitamin D supplementation reduces BP remains unclear. To systematically review whether vitamin D supplementation reduces BP in children and adolescents, we conducted a literature review according to the PRISMA statement. We included vitamin-D supplementation human interventions studies that reported on BP as an outcome. We searched PUBMED, MEDLINE, CINAHL, EMBASE, the Cochrane Library, and the clinical trials website. We also hand searched the references of the included articles and previous reviews of vitamin D therapy. No language or time restrictions were applied. We extracted data on population characteristics, baseline and endline vitamin D and BP values, and assessed the risk of bias of the included studies. We performed a narrative review of the findings, conducted a meta-analysis when possible, and performed sensitivity analyses to test the robustness of our results. We assessed the overall quality of the evidence produced in the meta-analysis. We included eight studies in our review and five studies in the meta-analysis, none of which included hypertensive only participants. The risk of bias was variable. In non-randomized studies, no effect of vitamin D supplementation was seen on systolic BP (SBP) (mean difference: 0.39 (95% confidence interval (CI): −0.9; 1.68) mmHg; p = 0.55; I2 = 0%). Only a significant decrease in diastolic BP (DBP) (mean difference: −1.87 (95% CI: −3.02; −0.72) mmHg; p = 0.001; I2 = 0%) was noted. Both analyses had a low quality of evidence. In randomized controlled trials (RCTs), no effect was noted on SBP (mean difference: −2.04 (95% CI: −5.12; 1.04) mmHg; p = 0.19; I2 = 71%) nor DBP (mean difference: 0.01 (95% CI: −1.09; 1.12) mmHg; p = 0.98; I2 = 0%). The final quality of evidence ranged between low and moderate. Sensitivity analyses did not affect the results. Vitamin D supplementation was found to be ineffective in lowering SBP and DBP in children and adolescents.
Lemon Balm and Its Constituent, Rosmarinic Acid, Alleviate Liver Damage in an Animal Model of Nonalcoholic Steatohepatitis
Authors: Kim Myungsuk , Yoo GyHye , Randy Ahmad , Son Yang-Ju , Hong Chi Rac , Kim Sang Min , Nho Chu Won
Published: April 2020

Nonalcoholic fatty liver disease (NAFLD) ranges in severity from hepatic steatosis to cirrhosis. Lemon balm and its major constituent, rosmarinic acid (RA), effectively improve the liver injury and obesity; however, their therapeutic effects on nonalcoholic steatohepatitis (NASH) are unknown. In this study, we investigated the effects of RA and a lemon balm extract (LBE) on NAFLD and liver fibrosis and elucidated their mechanisms. Palmitic acid (PA)-exposed HepG2 cells and db/db mice fed a methionine- and choline-deficient (MCD) diet were utilized to exhibit symptoms of human NASH. LBE and RA treatments alleviated the oxidative stress by increasing antioxidant enzymes and modulated lipid metabolism-related gene expression by the activation of adenosine monophosphate-activated protein kinase (AMPK) in vitro and in vivo. LBE and RA treatments inhibited the expression of genes involved in hepatic fibrosis and inflammation in vitro and in vivo. Together, LBE and RA could improve liver damage by non-alcoholic lipid accumulation and may be promising medications to treat NASH.
Normal-Weight Obesity Is Associated with Poorer Cardiometabolic Profile and Lower Physical Fitness Levels in Children and Adolescents
Authors: García-Hermoso Antonio , Agostinis-Sobrinho Cesar , Camargo-Villalba Gloria Eugenia , González-Jiménez Nubia Mercedes , Izquierdo Mikel , Correa-Bautista Jorge Enrique , Ramírez-Vélez Robinson
Published: April 2020

Normal-weight obesity (NWO) syndrome has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in Latin American children and adolescents. The aim of this study was two-fold: (i) to investigate whether Colombian youth with NWO syndrome have a poorer cardiometabolic profile and physical fitness performance than normal-weight lean (NWL) peers; and (ii) to determine if physical fitness levels are related to prevalence of normal-weight obesity in youth. This was an analytical cross-sectional study of 1919 youths (9–179 years old, 53.0% girls) in the capital area of Colombia. NWO was defined as a body mass index < 25 kg/m2 and a validated body fat percentage above the sex-age-specific 90th percentile for Colombian children and adolescents. Body fat was estimated using bioelectrical impedance analysis, cardiorespiratory fitness (CRF) was estimated using the 20-meter shuttle run test, and muscular fitness with the handgrip test. Biochemical profile blood samples were collected for cardiometabolic risk factors. After adjusting for chronological age, pubertal stage, and Mediterranean diet adherence, the NWO group (boys and girls) had significantly higher values for cardiometabolic risk factors, and waist circumference (WC) than the NWL group. The prevalence of NWO was lower in youth classified with healthy CRF (boys, odds ratio (OR) = 0.54, 95% confidence interval (CI) 0.37 to 0.78; girls, OR = 0.35, 95% CI 0.24 to 0.50), p < 0.001. Our findings indicate that using only body mass index for the assessment of cardiometabolic risk likely misrepresents true adiposity and suggest the need to include the assessment of body fat in the routine clinical evaluation of individuals during childhood and adolescence.
Furbellow (Brown Algae) Extract Increases Lifespan in Drosophila by Interfering with TOR-Signaling
Authors: Li Yang , Romey-Glüsing Renja , Tahan Zadeh Navid , von Frieling Jakob , Hoffmann Julia , Huebbe Patricia , Bruchhaus Iris , Rimbach Gerald , Fink Christine , Roeder Thomas
Published: April 2020

Algal products are well known for their health promoting effects. Nonetheless, an in depth understanding of the underlying molecular mechanisms is still only fragmentary. Here, we show that aqueous furbelow extracts (brown algae, Saccorhiza polyschides) lengthen the life of both sexes of the fruit fly Drosophila melanogaster substantially, if used as nutritional additives to conventional food. This life prolonging effect became even more pronounced in the presence of stressors, such as high-fat dieting of living under drought conditions. Application of the extracts did not change food intake, excretion, or other major physiological parameters. Nevertheless, effects on the intestinal microbiota were observed, leading to an increased species richness, which is usually associated with healthy conditions. Lifespan extension was not observed in target of rapamycin (TOR)-deficient animals, implying that functional TOR signaling is necessary to unfold the positive effects of brown algae extract (BAE) on this important trait. The lack of life lengthening in animals with deregulated TOR signaling exclusively targeted to body fat showed that this major energy storage organ is instrumental for transmitting these effects. In addition, expression of Imaginal morphogenesis protein-Late 2 (Imp-L2), an effective inhibitor of insulin signaling implies that BAE exerts their positive effects through interaction with the tightly interwoven TOR- and insulin-signaling systems, although insulin levels were not directly affected by this intervention.
Omega-3 Fatty Acids and Eye Health: Opinions and Self-Reported Practice Behaviors of Optometrists in Australia and New Zealand
Authors: Zhang Alexis Ceecee , Singh Sumeer , Craig Jennifer P. , Downie Laura E.
Published: April 2020

This study investigated optometrists’ attitudes and self-reported practice behaviors towards omega-3 fatty acids for eye health, and knowledge and understanding of their potential risks and benefits. An anonymous online survey was distributed to optometrists in Australia and New Zealand. Questions included practitioner demographics and practice modality; self-reported practices and recommendations relating to diet, nutritional supplements, and omega-3 fatty acids for age-related macular degeneration (AMD) and dry eye disease (DED); and practitioner knowledge about omega-3 fatty acids. Of 206 included surveys, most respondents (79%) indicated recommending for their patients to consume omega-3 fatty acids to improve their eye health. Sixty-eight percent of respondents indicated recommending omega-3-rich foods for AMD management, while 62% indicated recommending omega-3 supplements. Most respondents (78%) indicated recommending omega-3-rich foods or supplements for DED. For DED, recommended omega-3 supplement dosages were (median [inter-quartile range, IQR]) 2000 mg [1000–2750 mg] per day. The main sources of information reported by respondents to guide their clinical decision making were continuing education articles and conferences. In conclusion, optometrists routinely make clinical recommendations about diet and omega-3 fatty acids. Future education could target improving optometrists’ knowledge of differences in the evidence for whole-food versus supplement sources of omega-3 fatty acids in AMD. Further research is needed to address uncertainties in the evidence regarding optimal omega-3 dosage and formulation composition in DED.
Intestinal Permeability, Inflammation and the Role of Nutrients
Authors: Farré Ricard , Fiorani Marcello , Abdu Rahiman Saeed , Matteoli Gianluca
Published: April 2020

The interaction between host and external environment mainly occurs in the gastrointestinal tract, where the mucosal barrier has a critical role in many physiologic functions ranging from digestion, absorption, and metabolism. This barrier allows the passage and absorption of nutrients, but at the same time, it must regulate the contact between luminal antigens and the immune system, confining undesirable products to the lumen. Diet is an important regulator of the mucosal barrier, and the cross-talk among dietary factors, the immune system, and microbiota is crucial for the modulation of intestinal permeability and for the maintenance of gastrointestinal tract (GI) homeostasis. In the present review, we will discuss the role of a number of dietary nutrients that have been proposed as regulators of inflammation and epithelial barrier function. We will also consider the metabolic function of the microbiota, which is capable of elaborating the diverse nutrients and synthesizing products of great interest. Better knowledge of the influence of dietary nutrients on inflammation and barrier function can be important for the future development of new therapeutic approaches for patients with mucosal barrier dysfunction, a critical factor in the pathogenesis of many GI and non-GI diseases.
A Dietary Combination of Forskolin with Homotaurine, Spearmint and B Vitamins Protects Injured Retinal Ganglion Cells in a Rodent Model of Hypertensive Glaucoma
Authors: Cammalleri Maurizio , Dal Monte Massimo , Amato Rosario , Bagnoli Paola , Rusciano Dario
Published: April 2020

There is indication that nutritional supplements protect retinal cells from degeneration. In a previous study, we demonstrated that dietary supplementation with an association of forskolin, homotaurine, spearmint extract and B vitamins efficiently counteracts retinal dysfunction associated with retinal ganglion cell (RGC) death caused by optic nerve crush. We extended our investigation on the efficacy of dietary supplementation with the use of a mouse model in which RGC degeneration depends as closely as possible on intraocular pressure (IOP) elevation. In this model, injecting the anterior chamber of the eye with methylcellulose (MCE) causes IOP elevation leading to RGC dysfunction. The MCE model was characterized in terms of IOP elevation, retinal dysfunction as determined by electrophysiological recordings, RGC loss as determined by brain-specific homeobox/POU domain protein 3A immunoreactivity and dysregulated levels of inflammatory and apoptotic markers. Except for IOP elevation, dysfunctional retinal parameters were all recovered by dietary supplementation indicating the involvement of non-IOP-related neuroprotective mechanisms of action. Our hypothesis is that the diet supplement may be used to counteract the inflammatory processes triggered by glial cell activation, thus leading to spared RGC loss and the preservation of visual dysfunction. In this respect, the present compound may be viewed as a potential remedy to be added to the currently approved drug therapies for improving RGC protection.
Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically
Authors: Dahmana Handi , Mediannikov Oleg
Published: April 2020

Deadly pathogens and parasites are transmitted by vectors and the mosquito is considered the most threatening vector in public health, transmitting these pathogens to humans and animals. We are currently witnessing the emergence/resurgence in new regions/populations of the most important mosquito-borne diseases, such as arboviruses and malaria. This resurgence may be the consequence of numerous complex parameters, but the major cause remains the mismanagement of insecticide use and the emergence of resistance. Biological control programmes have rendered promising results but several highly effective techniques, such as genetic manipulation, remain insufficiently considered as a control mechanism. Currently, new strategies based on attractive toxic sugar baits and new agents, such as Wolbachia and Asaia, are being intensively studied for potential use as alternatives to chemicals. Research into new insecticides, Insect Growth Regulators, and repellent compounds is pressing, and the improvement of biological strategies may provide key solutions to prevent outbreaks, decrease the danger to at-risk populations, and mitigate resistance.
Influence of Aqueous Solubility-Enhancing Excipients on the Microstructural Characteristics of Furosemide-Loaded Electrospun Nanofibers
Authors: Kovács Andrea , Kazsoki Adrienn , Démuth Balázs , Szirányi Bernadett , Madarász János , Süvegh Károly , Zelkó Romána
Published: April 2020

Electrospun nanofibers were prepared from furosemide-containing hydroxypropyl cellulose and poly(vinylpyrrolidone) aqueous solutions using different solubility enhancers. In one case, a solubilizer, triethanolamine, was applied, while in the other case a pH-modifier, sodium hydroxide, was applied. Scanning electron microscopy (SEM) was carried out for morphological characterization of the fibers. The SEM images indicated similar mean diameter size of the two fibrous formulations. However, in contrast to the NaOH-containing fibers of normal diameter distribution, the triethanolamine-containing fibers showed approximately normal diameter distribution, possibly due to their plasticizing effect and the consequent slightly ribbon-like morphology. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), powder X-ray diffraction (XRD) and positron annihilation lifetime spectroscopy (PALS) were applied for microstructural characterization. The FTIR measurements confirmed that furosemide salt was formed in both cases. There was no sign of any crystallinity based on the XRD measurements. However, the PALS highlighted the differences in the average o-Ps lifetime values and distributions of the furosemide-loaded fibrous formulations. The two types of electrospun nanofibrous formulations containing amorphous furosemide salt showed similar macrostructures but different microstructural characteristics depending on the type of solubility enhancers, which lead to altered storage stability.
β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity
Authors: Soleimanian Yasamin , Goli Sayed Amir Hossein , Varshosaz Jaleh , Di Cesare Mannelli Lorenzo , Ghelardini Carla , Cirri Marzia , Maestrelli Francesca
Published: April 2020

The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessibility and release were extensively studied. Both NLC preparations remained relatively stable during the four weeks of storage at different conditions (4, 25 and 40 °C), with more superior stability at lower temperatures. The in vitro digestion experiment indicated a high physical stability after exposure to the simulated mouth and stomach stages and an improved overall β-sitosterol bioaccessibility at the end of the digestion. The NLCs presented an increased solubility and gradual release which could be justified by the remarkable affinity of β-sitosterol to the complex lipid mixture. An in vivo study demonstrated an improved reduction in the total cholesterol and low-density lipoprotein cholesterol plasma levels in mice compared with the drug suspension. These investigations evidenced the potential of the developed NLC formulations for the enhancement of solubility and in vivo performance of β-sitosterol.
Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones
Authors: Brillault Julien , Tewes Frédéric
Published: April 2020

Pulmonary drug delivery is a promising strategy to treat lung infectious disease as it allows for a high local drug concentration and low systemic side effects. This is particularly true for low-permeability drugs, such as tobramycin or colistin, that penetrate the lung at a low rate after systemic administration and greatly benefit from lung administration in terms of the local drug concentration. However, for relatively high-permeable drugs, such as fluoroquinolones (FQs), the rate of absorption is so high that the pulmonary administration has no therapeutic advantage compared to systemic or oral administration. Formulation strategies have thus been developed to decrease the absorption rate and increase FQs’ residence time in the lung after inhalation. In the present review, some of these strategies, which generally consist of either decreasing the lung epithelium permeability or decreasing the release rate of FQs into the epithelial lining fluid after lung deposition, are presented in regards to their clinical aspects.
Pharmacist-Driven Culture and Sexually Transmitted Infection Testing Follow-Up Program in the Emergency Department
Authors: Shealy Stephanie C. , Alexander Christine , Hardison Tina Grof , Magagnoli Joseph , Justo Julie Ann , Derrick Caroline , Kohn Joseph , Winders Hana Rac , Privette Troy , Al-Hasan Majdi N. , Bookstaver P. Brandon
Published: April 2020

Expanding pharmacist-driven antimicrobial stewardship efforts in the emergency department (ED) can improve antibiotic management for both admitted and discharged patients. We piloted a pharmacist-driven culture and rapid diagnostic technology (RDT) follow-up program in patients discharged from the ED. This was a single-center, pre- and post-implementation, cohort study examining the impact of a pharmacist-driven culture/RDT follow-up program in the ED. Adult patients discharged from the ED with subsequent positive cultures and/or RDT during the pre- (21 August 2018–18 November 2018) and post-implementation (19 November 2018–15 February 2019) periods were screened for inclusion. The primary endpoints were time from ED discharge to culture/RDT review and completion of follow-up. Secondary endpoints included antimicrobial agent prescribed during outpatient follow-up, repeat ED encounters within 30 days, and hospital admissions within 30 days. Baseline characteristics were analyzed using descriptive statistics. Time-to-event data were analyzed using the Wilcoxon signed-rank test. One-hundred-and-twenty-seven patients were included, 64 in the pre-implementation group and 63 in the post-implementation group. There was a 36.3% reduction in the meantime to culture/RDT data review in the post-implementation group (75.2 h vs. 47.9 h, p < 0.001). There was a significant reduction in fluoroquinolone prescribing in the post-implementation group (18.1% vs. 5.4%, p = 0.036). The proportion of patients who had a repeat ED encounter or hospital admission within 30 days was not significantly different between the pre- and post-implementation groups (15.6 vs. 19.1%, p = 0.78 and 9.4% vs. 7.9%, p = 1.0, respectively). Introduction of a pharmacist culture and RDT follow-up program in the ED reduced time to data review, time to outpatient intervention and outpatient follow-up of fluoroquinolone prescribing.
Insight into the Chromosome Structure of the Cultivated Tetraploid Alfalfa (Medicago sativa subsp. sativa L.) by a Combined Use of GISH and FISH Techniques
Authors: Falistocco Egizia
Published: April 2020

Cytogenetic research in Medicago sativa subsp. sativa L., the cultivated tetraploid alfalfa (2n = 4x = 32), has lagged behind other crops mostly due to the small size and the uniform morphology of its chromosomes. However, in the last decades, the development of molecular cytogenetic techniques based on in situ hybridization has largely contributed to overcoming these limitations. The purpose of this study was to extend our knowledge about the chromosome structure of alfalfa by using a combination of genomic in situ hybridization (GISH) and fluorescence in situ hybridization (FISH) techniques. The results of self-GISH (sGISH) suggested that a substantial part of the repetitive fraction of the genome of subsp. sativa is constituted by tandem repeats typical of satellite DNA. The coincidence of sGISH and C-banding patterns supported this assumption. The FISH mapping of the Arabidopsis-type TTTAGGG telomeric repeats demonstrated, for the first time, that the alfalfa telomeres consist of this type of sequence and revealed a massive presence of interstitial telomeric repeats (ITRs). In the light of this finding M. sativa appears to be a suitable material for studying the origin and function of such extra telomeric repeats. To further exploit this result, investigation will be extended to the diploid subspp. coerulea and falcata in order to explore possible connections between the distribution of ITRs, the ploidy level, and the evolutionary pathway of the taxa.
Hemolytic and Antimicrobial Activities of a Series of Cationic Amphiphilic Copolymers Comprised of Same Centered Comonomers with Thiazole Moieties and Polyethylene Glycol Derivatives
Authors: Cuervo-Rodríguez R. , Muñoz-Bonilla A. , López-Fabal F. , Fernández-García M.
Published: April 2020

A series of well-defined antimicrobial polymers composed of comonomers bearing thiazole ring (2-(((2-(4-methylthiazol-5-yl)ethoxy)carbonyl)oxy)ethyl methacrylate monomer (MTZ)) and non-hemotoxic poly(ethylene glycol) side chains (poly(ethylene glycol) methyl ether methacrylate (PEGMA)) were synthesized by reversible addition-fragmentation chain transfer (RAFT) polymerization. By post-polymerization functionalization strategy, polymers were quaternized with either butyl or octyl iodides to result in cationic amphiphilic copolymers incorporating thiazolium groups, thus with variable hydrophobic/hydrophilic balance associated to the length of the alkylating agent. Likewise, the molar percentage of PEGMA was modulated in the copolymers, also affecting the amphiphilicity. The antimicrobial activities of these cationic polymers were determined against Gram-positive and Gram-negative bacteria and fungi. Minimum inhibitory concentration (MIC) was found to be dependent on both length of the alkyl hydrophobic chain and the content of PEGMA in the copolymers. More hydrophobic octylated copolymers were found to be more effective against all tested microorganisms. The incorporation of non-ionic hydrophilic units, PEGMA, reduces the hydrophobicity of the system and the activity is markedly reduced. This effect is dramatic in the case of butylated copolymers, in which the hydrophobic/hydrophilic balance is highly affected. The hemolytic properties of polymers analyzed against human red blood cells were greatly affected by the hydrophobic/hydrophilic balance of the copolymers and the content of PEGMA, which drastically reduces the hemotoxicity. The copolymers containing longer hydrophobic chain, octyl, are much more hemotoxic than their corresponding butylated copolymers.
Development and Validation of a Test Mold for Thermoplastic Resin Transfer Molding of Reactive PA-6
Authors: Boros Róbert , Sibikin Ilya , Ageyeva Tatyana , Kovács József Gábor
Published: April 2020

Thermoplastic resin transfer molding (T-RTM) is a cutting-edge manufacturing technique for high-volume production of composites with a recyclable thermoplastic matrix. Although a number of reactive thermoplastic matrices as well as industrial manufacturing equipment for T-RTM are commercially available today, the design of a T-RTM mold is still based on the skills and personal experience of the designer. This study summarizes the best knowledge and expertise in mold design and manufacturing and introduces an innovative mold for T-RTM. A concept and basic principles for designing a T-RTM mold are formulated in this study. The mold developed is manufactured and validated.
Wear Resistant Nanocomposites Based on Biomedical Grade UHMWPE Paraffin Oil and Carbon Nano-Filler: Preliminary Biocompatibility and Antibacterial Activity Investigation
Authors: Catauro Michelina , Scolaro Cristina , Dal Poggetto Giovanni , Pacifico Severina , Visco Annamaria
Published: April 2020

In the present paper, we investigate the effectiveness of nanocomposites (composed of ultra-high molecular weight polyethylene (UHMWPE) mixed with carbon nano-filler (CNF) and medical grade paraffin oil (PO), from the biological point of view. Wear measurements were carried out without (air) and with lubricant (distilled water, natural, and artificial lubricant), and antibacterial activity and cytotoxicity were evaluated. The results highlighted that the presence of CNF is important in the nanocomposite formulation because it reduces the wear rate and prevents oxidative degradation during its processing. An amount of 1.0 wt % of CNF is best because it reaches the optimal distribution within the polymeric matrix, resulting in the best wear resistant, bio-active, and anti-bacterial nanocomposite among all investigated samples.
Effect of Gear Pump Extrusion Processing on the Properties of Fiber Reinforced Rubber Composites
Authors: Tian Xiaolong , Zhu Lin , Li Kunling , Wang Kongshuo , Bian Huiguang , Li Lin , Li Shaoming , Wang Chuansheng
Published: April 2020

Short fiber reinforced rubber composites have been widely used in rubber products attributed to their excellent wear resistance. However, there are still some serious problems in the processing of short fiber reinforced rubber composites, such as Mooney viscosity increasing, temperature and extrusion pressure rising, and unstable extrusion quality. In particular, short fibers need to be extruded in a specific direction during the molding process, and the problems in this process are particularly prominent. In this manuscript, the influence of gear pump assisted extrusion on the properties of short fiber rubber composites is studied. The experimental results show that the application of a gear pump to assist extrusion could significantly increase the die pressure, reduce the extrusion temperature of the blend, and improve the extrusion efficiency and stability of the blend. Furthermore, it could improve the vulcanization efficiency, increase the tensile strength and tear strength of the compound, reduce wear, and guarantee the quality of extrusion products.
Religious Interactions in Deliberative Democratic Systems Theory
Authors: Stanley Timothy
Published: April 2020

The following essay begins by outlining the pragmatist link between truth claims and democratic deliberations. To this end, special attention will be paid to Jeffrey Stout’s pragmatist enfranchisement of religious citizens. Stout defends a deliberative notion of democracy that fulfills stringent criteria of inclusion and security against domination. While mitigating secular exclusivity, Stout nonetheless acknowledges the new visibility of religion in populist attempts to dominate political life through mass rule and charismatic authorities. In response, I evaluate recent innovations in deliberative democratic systems theory (DDST). By adding a pragmatist inflection to DDST, I aim to apprehend the complex religious interactions between partisan interest groups as well as the trust-building capacities of minipublics.
The Relevance of God to Religious Believers and Non-Believers
Authors: Leite Ângela , Vidal Diogo Guedes , Dinis Maria Alzira Pimenta , Sousa Hélder Fernando Pedrosa e , Dias Paulo
Published: April 2020

This study presents a review about what great figures of history thought about the existence of God and a worldwide comparison between religious believers and non-believers using the World Social Survey (WSS) database, comprising a sample of 90,350 respondents. Results reveal that most people believe in the existence of God and consider that God is important and very important in their lives. Believers are mainly women; younger than non-believers; mostly married; less educated than non-believers; most of whom work, though fewer hours than non-believers; and perceive themselves as belonging to the middle class. There are more believers with no formal education than non-believers. The diversity of religious believers and non-believers, visible in the perspectives of humanity’s important personalities, mirrors the diversity of ordinary people towards the relevance of God. The results obtained point to a correlation between the belief in God and the studied sociodemographic variables but also suggest that the difference between believers and non-believers may be artificial, having resulted from the adopted methodology. The relationship found between being a believer and defending traditional values also corroborates with previous studies, suggesting that humankind needs God to give meaning to the world around them, namely, in morality and conduct terms.
Effects of Category Aggregation on Land Change Simulation Based on Corine Land Cover Data
Authors: Varga Orsolya Gyöngyi , Pontius Jr Robert Gilmore , Szabó Zsuzsanna , Szabó Szilárd
Published: April 2020

Several factors influence the performance of land change simulation models. One potentially important factor is land category aggregation, which reduces the number of categories while having the potential to reduce also the size of apparent land change in the data. Our article compares how four methods to aggregate Corine Land Cover categories influence the size of land changes in various spatial extents and consequently influence the performance of 114 Cellular Automata-Markov simulation model runs. We calculated the reference change during the calibration interval, the reference change during the validation interval and the simulation change during the validation interval, along with five metrics of simulation performance, Figure of Merit and its four components: Misses, Hits, Wrong Hits and False Alarms. The Corine Standard Level 1 category aggregation reduced change more than any of the other aggregation methods. The model runs that used the Corine Standard Level 1 aggregation method tended to return lower sizes of changing areas and lower values of Misses, Hits, Wrong Hits and False Alarms, where Hits are correctly simulated changes. The behavior-based aggregation method maintained the most change while using fewer categories compared to the other aggregation methods. We recommend an aggregation method that maintains the size of the reference change during the calibration and validation intervals while reducing the number of categories, so the model uses the largest size of change while using fewer than the original number of categories.
Spatial and Temporal Variation of Aerosol and Water Vapour Effects on Solar Radiation in the Mediterranean Basin during the Last Two Decades
Authors: Obregón Maria A. , Costa Maria João , Silva Ana Maria , Serrano Antonio
Published: April 2020

This study aims to calculate and analyse the spatial and temporal variation of aerosol optical thickness (AOT) and precipitable water vapour (PWV) and their effects on solar radiation at the surface in the Mediterranean basin, one of the maritime areas with the largest aerosol loads in the world. For the achievement of this objective, a novel and validated methodology was applied. Satellite data, specifically CERES (Clouds and the Earth’s Radiant Energy System) SYN1deg products during the period 2000–2018, were used. Results show that the spatial distribution of AOT and PWV are closely linked to the spatial distributions of its effects on solar radiation. These effects are negative, indicating a reduction of solar radiation reaching the surface due to aerosol and water vapour effects. This reduction ranges between 2% and 8% for AOT, 11.5% and 15% for PWV and 14% and 20% for the combined effect. The analysis of the temporal distribution has focused on the detection of trends from their anomalies. This study has contributed to a better understanding of AOT and PWV effects on solar radiation over the Mediterranean basin, one of the most climatically sensitive regions of the planet, and highlighted the importance of water vapour.
Remote Sensing of Boreal Wetlands 1: Data Use for Policy and Management
Authors: Chasmer Laura , Cobbaert Danielle , Mahoney Craig , Millard Koreen , Peters Daniel , Devito Kevin , Brisco Brian , Hopkinson Chris , Merchant Michael , Montgomery Joshua , Nelson Kailyn , Niemann Olaf
Published: April 2020

Wetlands have and continue to undergo rapid environmental and anthropogenic modification and change to their extent, condition, and therefore, ecosystem services. In this first part of a two-part review, we provide decision-makers with an overview on the use of remote sensing technologies for the ‘wise use of wetlands’, following Ramsar Convention protocols. The objectives of this review are to provide: (1) a synthesis of the history of remote sensing of wetlands, (2) a feasibility study to quantify the accuracy of remotely sensed data products when compared with field data based on 286 comparisons found in the literature from 209 articles, (3) recommendations for best approaches based on case studies, and (4) a decision tree to assist users and policymakers at numerous governmental levels and industrial agencies to identify optimal remote sensing approaches based on needs, feasibility, and cost. We argue that in order for remote sensing approaches to be adopted by wetland scientists, land-use managers, and policymakers, there is a need for greater understanding of the use of remote sensing for wetland inventory, condition, and underlying processes at scales relevant for management and policy decisions. The literature review focuses on boreal wetlands primarily from a Canadian perspective, but the results are broadly applicable to policymakers and wetland scientists globally, providing knowledge on how to best incorporate remotely sensed data into their monitoring and measurement procedures. This is the first review quantifying the accuracy and feasibility of remotely sensed data and data combinations needed for monitoring and assessment. These include, baseline classification for wetland inventory, monitoring through time, and prediction of ecosystem processes from individual wetlands to a national scale.
Structural Changes in the Romanian Economy Reflected through Corine Land Cover Datasets
Authors: Rusu Alexandru , Ursu Adrian , Stoleriu Cristian Constantin , Groza Octavian , Niacșu Lilian , Sfîcă Lucian , Minea Ionuț , Stoleriu Oana Mihaela
Published: April 2020

During the last 30 years, the Romanian economy has faced different challenges due to structural readjustments, overcoming crisis and globalization. The share of primary and secondary sectors in the gross domestic product have strongly decreased, while the services have taken off. The main objective for this study is to observe how these economic readjustments can be assessed and measured using the Corine Land Cover datasets from 1990, 2000, 2006, 2012 and 2018 (with special observation on the range 2006 and 2018, after Romania was included in European Union). Despite some of the methodological limitations (like the minimum surface change), the Corine Land Cover turned out to be a powerful tool and it allowed us to detect an intense correlation between the socioeconomic and the structural trends in land use, in specific spatial contexts. The artificial surfaces are constantly increasing and this trend is rather visible as a distance function to the major Romanian cities. The most interesting changes occurred in the case of the agricultural polygons. The main trend emphasized by our analysis regards the redeployment of large farms in areas of agronomic and environmental territorial optimum. Such is the case for vineyards (after a decline during 2000–2006) and for annual cultures. All these changes in land-use patterns are too complex to be encompassed by a single methodology, which is why we used different tools, ranging from spatial analysis to geo-economic modeling, in order to detect how the Corine Land Cover datasets might be used for a better understanding of the Romanian economic readjustments.
Superpixel-Based Mixed Noise Estimation for Hyperspectral Images Using Multiple Linear Regression
Authors: Sun Lei , Li Bujin , Nian Yongjian
Published: April 2020

HSIs (hyperspectral images) obtained by new-generation hyperspectral sensors contain both electronic noise and photon noise with comparable power. Therefore, both the SI (signal-independent) component and the SD (signal-dependent) component have to be considered. In this paper, a superpixel-based noise estimation algorithm using MLR (multiple linear regression) is proposed for the above mixed noise to estimate the noise standard deviation of both SI component and SD component. First, superpixel segmentation is performed on the first principal component obtained by MNF (minimum noise fraction)-based dimensionality reduction to generate non-overlapping regions with similar pixels. Then, MLR is performed to remove the spectral correlation, and a system of linear equations with respect to noise variances is established according to the local sample statistics calculated within each superpixel. By solving the equations in terms of the least-squares method, the noise variances are determined. The experimental results show that the proposed algorithm provides more accurate local sample statistics, and yields a more accurate noise estimation than the other state-of-the-art algorithms for simulated HSIs. The results of the real-life data also verify the effectiveness of the proposed algorithm.
Detection of Magnesite and Associated Gangue Minerals using Hyperspectral Remote Sensing—A Laboratory Approach
Authors: Chung Baru , Yu Jaehyung , Wang Lei , Kim Nam Hoon , Lee Bum Han , Koh Sangmo , Lee Sangin
Published: April 2020

This study introduced a detection method for magnesite and associated gangue minerals, including dolomite, calcite, and talc, based on mineralogical, chemical, and hyperspectral analyses using hand samples from thirteen different source locations and Specim hyperspectral short wave infrared (SWIR) hyperspectral images. Band ratio methods and logistic regression models were developed based on the spectral bands selected by the random forest algorithm. The mineralogical analysis revealed the heterogeneity of mineral composition for naturally occurring samples, showing various carbonate and silicate minerals as accessory minerals. The Mg and Ca composition of magnesite and dolomite varied significantly, inferring the mixture of minerals. The spectral characteristics of magnesite and associated gangue minerals showed major absorption features of the target minerals mixed with the absorption features of accessory carbonate minerals and talc affected by mineral composition. The spectral characteristics of magnesite and dolomite showed a systematic shift of the Mg-OH absorption features toward a shorter wavelength with an increased Mg content. The spectral bands identified by the random forest algorithm for detecting magnesite and gangue minerals were mainly associated with spectral features manifested by Mg-OH, CO3, and OH. A two-step band ratio classification method achieved an overall accuracy of 92% and 55.2%. The classification models developed by logistic regression models showed a significantly higher accuracy of 98~99.9% for training samples and 82–99.8% for validation samples. Because the samples were collected from heterogeneous sites all over the world, we believe that the results and the approach to band selection and logistic regression developed in this study can be generalized to other case studies of magnesite exploration.
Exploring the Combined Effect of Urbanization and Climate Variability on Urban Vegetation: A Multi-Perspective Study Based on More than 3000 Cities in China
Authors: Liang Ze , Wang Yueyao , Sun Fuyue , Jiang Hong , Huang Jiao , Shen Jiashu , Wei Feili , Li Shuangcheng
Published: April 2020

More than 3000 cities in China were used to study the effect of urbanization and local climate variability on urban vegetation across different geographical and urbanization conditions. The national scale estimation shows that China’s urban vegetation depicts a trend of degradation from 2000 to 2015, especially in developed areas such as the Yangtze River Delta. According to the panel models, the increase of precipitation (PREC), solar radiation (SRAD), air temperature (TEMP), and specific humidity (SHUM) all enhance urban vegetation, while nighttime light intensity (NLI), population density (POPDEN), and fractal dimension (FRAC) do the opposite. The effects change along the East–West gradient; the influences of PREC and SHUM become greater, while those of TEMP, SRAD, NLI, AREA, and FRAC become smaller. PREC, SHUM, and SRAD play the most important roles in Northeast, Central, and North China, respectively. The role of FRAC and NLI in East China is much greater than in other regions. POPDEN remains influential across all altitudes, while FRAC affects only low-altitude cities. NLI plays a greater role in larger cities, while FRAC and POPDEN are the opposite. In cities outside of the five major urban agglomerations, PREC has a great influence while the key factors are more diversified inside.
Tree, Shrub, and Grass Classification Using Only RGB Images
Authors: Ayhan Bulent , Kwan Chiman
Published: April 2020

In this work, a semantic segmentation-based deep learning method, DeepLabV3+, is applied to classify three vegetation land covers, which are tree, shrub, and grass using only three band color (RGB) images. DeepLabV3+’s detection performance has been studied on low and high resolution datasets that both contain tree, shrub, and grass and some other land cover types. The two datasets are heavily imbalanced where shrub pixels are much fewer than tree and grass pixels. A simple weighting strategy known as median frequency weighting was incorporated into DeepLabV3+ to mitigate the data imbalance issue, which originally used uniform weights. The tree, shrub, grass classification performances are compared when all land cover types are included in the classification and also when classification is limited to the three vegetation classes with both uniform and median frequency weights. Among the three vegetation types, shrub is found to be the most challenging one to classify correctly whereas correct classification accuracy was highest for tree. It is observed that even though the median frequency weighting did not improve the overall accuracy, it resulted in better classification accuracy for the underrepresented classes such as shrub in our case and it also significantly increased the average class accuracy. The classification performance and computation time comparison of DeepLabV3+ with two other pixel-based classification methods on sampled pixels of the three vegetation classes showed that DeepLabV3+ achieves significantly higher accuracy than these methods with a trade-off for longer model training time.
Wave Signatures in Total Electron Content Variations: Filtering Problems
Authors: Maletckii Boris , Yasyukevich Yury , Vesnin Artem
Published: April 2020

Over recent years, global navigation satellite systems (GNSSs) have been increasingly used to study near-Earth space. The basis for such studies is the total electron content (TEC) data. Standard procedures for detecting TEC wave signatures include variation selection and detrending. Our experience showed that the inaccurate procedure causes artifacts in datasets which might affect data interpretation, particularly in automated processing. We analyzed the features of various detrending and variation selection methods. We split the problem of the GNSS data filtering into two subproblems: detrending and variation selection. We examined centered moving average, centered moving median, 6th-order polynomial, Hodrick–Prescott filter, L1 filter, cubic smoothing spline, double-applied moving average for the GNSS-TEC detrending problem, and centered moving average, centered moving median, Butterworth filter, type I Chebyshev filter for the GNSS-TEC variation selection problem in this paper. We carried out the analysis based on both model and experimental data. Modeling was based on simple analytical models as well as the International Reference Ionosphere. Analysis of TEC variations of 2–10 min, 10–20 min, and 20–60 min under insufficient detrending conditions showed that the higher errors appear for the longer periods (20–60 min). For the detrending problem, the smoothing cubic spline provided the best results among the algorithms discussed in this paper. The spline detrending featured the minimal value of the mean bias error (MBE) and the root-mean-square error (RMSE), as well as high correlation coefficient. The 6th-order polynomial also produced good results. Spline detrending does not introduce a RMSE more than 0.25 TECU and MBE > 0.35 TECU for IRI trends, while, for the 6th-order polynomial, these errors can exceed 1 TECU in some cases. However, in 95% of observations the RMSE and MBE do not exceed 0.05 TECU. For the variation selection, the centered moving average filter showed the best performance among the algorithms discussed in this paper.
A Conceptual Approach to Modeling the Geospatial Impact of Typical Urban Threats on the Habitat Quality of River Corridors
Authors: Hack Jochen , Molewijk Diana , Beißler Manuel R.
Published: April 2020

While for most of a landscape, urbanization leads to a significant habitat loss, rivers in urban areas are usually maintained or developed for their drainage function. Rivers are often the most important biophysical and ecological connection of cities with their surrounding ecosystems, although usually heavily altered due to urban impacts. For the conservation of urban rivers as ecological corridors, it is important to assess the impact of typical urban threats on habitat quality. In this study, we used the InVEST (Integrated Valuation of Environmental Services and Trade-offs) habitat quality model to assess the individual and combined impacts of built-up areas, first- and second-order road and water pollution from urban drainage, and wastewater discharge on habitat quality within a 200 m wide river corridor. The Pochote River in León, Nicaragua, was used as a case study. Our results show the spatial distribution and magnitude of the individual threat impacts, as well as the respective contribution of each threat to the overall impact of urbanization on the habitat quality within the river corridor. While close to the city center, all threats almost equally contributed to severe habitat degradation, while further downstream, an individual threat influence became more distinct with only water pollution having a consistent negative impact. We concluded that the InVEST habitat quality model can be used to assess the impact of typical urban threats on habitat quality in river corridors at a high spatial resolution. The results can help to improve urban planning and development to improve habitat conservation along urban rivers.