bluuebunny/crossref_metadata_2025 huggingface dataset:
Socioeconomic Status and Route Characteristics in Relation to Children’s Exposure to Air Pollution from Road Traffic While Walking to School in Auckland, New Zealand
Authors: Rafiepourgatabi Mehrdad , Woodward Alistair , Salmond Jennifer A. , Dirks Kim N.
Published: May 2021

Pedestrian exposure to traffic-related air pollution depends on many factors; including the nature of the traffic on nearby roads and the route characteristics. In this study, we investigated the effects of differences in vehicle fleet and transport infrastructure on children’s exposure to traffic-related air pollution during their morning walk to school in Auckland, New Zealand. Five pairs of routes to schools—each including a low and a high socioeconomic status (SES) school—were selected and traversed over 7–8 days for each pair while measuring particle number concentration (PNC) and GPS coordinates. At the same time, a sample of 200 license plates of cars from each school’s neighborhood was captured using videos, and the age of each car was extracted using an online database. Both the mean age of the cars and the percentage of old cars (>14 years) were found to be higher in the low SES areas. However, neither measure of vehicle age was associated with a significant difference in exposure to PNC for pedestrians. Route features including narrow footpaths and a higher density of traffic lights may be associated with higher levels of PNC exposure. These findings provide insight into the role of urban design in promoting healthy commutes to school.
Older Adolescents Who Did or Did Not Experience COVID-19 Symptoms: Associations with Mental Health, Risk Perception and Social Connection
Authors: Burrai Jessica , Barchielli Benedetta , Cricenti Clarissa , Borrelli Anna , D’Amato Sabina , Santoro Massimo , Vitale Margherita , Ferracuti Stefano , Giannini Anna Maria , Quaglieri Alessandro
Published: May 2021

After a decrease in detected cases in the summer, Europe faced the emergence of a second wave of coronavirus disease 19 (COVID-19). Few studies have investigated adolescents, who may constitute a target group with possible lower compliance to public health measures, particularly the social distancing measures. A total sample of 492 participants was included in the study, and the ages of the participants ranged from 18–24 years. According to the hypothesis of our study, the sample was divided into two groups: those who experienced COVID-19 symptoms and those who did not experience COVID-19 symptoms. Demographic characteristics, knowledge, perceptions, and behaviors related to COVID-19 were investigated with ad hoc items; in addition, mood disorders, self-efficacy, and social connectedness were explored. Our results showed significant differences in the variables of risk perception, self-efficacy, and measures of belongingness among older adolescents who did or did not experience COVID-19 symptoms. In this period, adolescents experienced unprecedented disruptions in their daily lives, leading them to isolation and loneliness. Compliance with restrictive measures is considered both a proactive behavior and a social responsibility, especially if supported by prosocial reasons to prevent others from getting sick; therefore, this must be the focus of raising awareness of anti-COVID-19 compliance among adolescents.
Different Time Scale Distribution of Negative Air Ions Concentrations in Mount Wuyi National Park
Authors: Li Changshun , Xie Ziyang , Chen Bo , Kuang Kaijin , Xu Daowei , Liu Jinfu , He Zhongsheng
Published: May 2021

The concentration of negative air ions (NAIs) is an important indicator of air quality. Here, we analyzed the distribution patterns of negative air ion (NAI) concentrations at different time scales using statistical methods; then described the contribution of meteorological factors of the different season to the concentration of NAIs using correlation analysis and regression analysis; and finally made the outlook for the trends of NAI concentrations in the prospective using the auto regressive integrated moving average (ARIMA) models. The dataset of NAI concentrations and meteorological factors measured at the fixed stations in the Mountain Wuyi National Park were obtained from the Fujian Provincial Meteorological Bureau. The study showed that NAI concentrations were correlated with relative humidity spanning all seasons. Water was an important factor affecting the distribution of NAI concentrations in different time series. Compared with other ARIMA models, the outlook value of the ARIMA (0,1, 1) model was closer to the original data and the errors were smaller. This article provided a unique perspective on the study of the distribution of negative air oxygen ions over time series.
Foot Pain and Morphofunctional Foot Disorders in Patients with Rheumatoid Arthritis: A Multicenter Cross-Sectional Study
Authors: Reina-Bueno María , Munuera-Martínez Pedro V. , Pérez-García Sergio , Vázquez-Bautista María del Carmen , Domínguez-Maldonado Gabriel , Palomo-Toucedo Inmaculada C.
Published: May 2021

Foot problems are highly prevalent in people with rheumatoid arthritis. This study aims to explore the foot morphology, pain and function in rheumatoid arthritis patients and the relation with the time of disease debut. A cross-sectional study was designed. Footprint, the Foot Posture Index, the hallux valgus prevalence, foot pain and function in 66 rheumatoid arthritis patients and the association with time since diagnosis, were recorded. The Foot Function Index, the Manchester Foot Pain and Disability Index, the Visual Analogic Scale, and the Manchester Scale for hallux valgus were administered and analyzed in two groups, with less and more than 10 years of diagnosis of the disease. A high prevalence of pronated (right 36.8% and left 38.6%) and highly pronated (right 15.8% and left 15.8%) feet was observed, as well as an elevated percentage of low arched footprints (right 68.4 and left 66.7%) and hallux valgus (right 59.6% and left 54.4%). Hallux valgus prevalence, toe deformities and Foot Function Index (Functional limitation) factors were significantly associated with the time since RA diagnosed adjusted for the other factors. The adjusted odds ratio of Hallux valgus prevalence was 4.9 (1.2–19.7). In addition, the foot function was diminished, and foot pain was present in most participants. In conclusion, rheumatoid arthritis patients’ feet showed altered morphology and function, and with longer rheumatoid arthritis history, metatarsophalangical stability and foot function, but not pain and global foot posture, were likely to deteriorate.
A Proposed Framework for Identification of Indicators to Model High-Frequency Cities
Authors: Senousi Ahmad M. , Zhang Junwei , Shi Wenzhong , Liu Xintao
Published: May 2021

A city is a complex system that never sleeps; it constantly changes, and its internal mobility (people, vehicles, goods, information, etc.) continues to accelerate and intensify. These changes and mobility vary in terms of the attributes of the city, such as space, time and cultural affiliation, which characterise to some extent how the city functions. Traditional urban studies have successfully modelled the ‘low-frequency city’ and have provided solutions such as urban planning and highway design for long-term urban development. Nevertheless, the existing urban studies and theories are insufficient to model the dynamics of a city’s intense mobility and rapid changes, so they cannot tackle short-term urban problems such as traffic congestion, real-time transport scheduling and resource management. The advent of information and communication technology and big data presents opportunities to model cities with unprecedented resolution. Since 2018, a paradigm shift from modelling the ‘low-frequency city’ to the so-called ‘high-frequency city’ has been introduced, but hardly any research investigated methods to estimate a city’s frequency. This work aims to propose a framework for the identification and analysis of indicators to model and better understand the concept of a high-frequency city in a systematic manner. The methodology for this work was based on a content analysis-based review, taking into account specific criteria to ensure the selection of indicator sets that are consistent with the concept of the frequency of cities. Twenty-two indicators in five groups were selected as indicators for a high-frequency city, and a framework was proposed to assess frequency at both the intra-city and inter-city levels. This work would serve as a pilot study to further illuminate the ways that urban policy and operations can be adjusted to improve the quality of city life in the context of a smart city.
Sex Differences in Circadian Clock Genes and Myocardial Infarction Susceptibility
Authors: Škrlec Ivana , Talapko Jasminka , Juzbašić Martina , Steiner Robert
Published: May 2021

The growing body of evidence shows a significant difference in the circadian rhythm of cardiovascular disease based on biological sex. The incidence of cardiovascular disease varies between women and men. Additionally, biological sex is vital for the timely application of therapy—chronotherapy, which benefits both sexes. This study aimed to examine the potential difference of single nucleotide polymorphisms (SNPs) of the circadian rhythm genes ARNTL, CLOCK, CRY2 and PER2 in women and men with myocardial infarction. A cross-sectional study was conducted, including 200 patients with myocardial infarction. Altogether, ten single nucleotide polymorphisms in the ARNTL, CLOCK, CRY2 and PER2 genes were analyzed. The Chi-square test yielded statistically significant differences in CLOCK gene rs11932595 polymorphism in a recessive genotype model between women and men with a p-value of 0.03 and an odds ratio 2.66, and a corresponding 95% confidence interval of 1.07 to 6.66. Other analyzed polymorphisms of the circadian rhythm genes ARNTL, CRY2, and PER2 did not significantly differ between the sexes. According to the study’s current results, the CLOCK gene’s genetic variability might affect myocardial infarction concerning biological sex.
Prognostic Value of the Albumin-Bilirubin Grade for the Prediction of Post-Hepatectomy Liver Failure: A Systematic Review and Meta-Analysis
Authors: Marasco Giovanni , Alemanni Luigina Vanessa , Colecchia Antonio , Festi Davide , Bazzoli Franco , Mazzella Giuseppe , Montagnani Marco , Azzaroli Francesco
Published: May 2021

(1) Introduction: Liver resection (LR) for hepatocellular carcinoma (HCC) is often burdened by life-threatening complications, such as post-hepatectomy liver failure (PHLF). The albumin-bilirubin (ALBI) score can accurately evaluate liver function and the long-term prognosis of HCC patients, including PHLF. We aimed to evaluate the diagnostic value of the ALBI grade in predicting PHLF in HCC patients undergoing LR. (2) Methods: MEDLINE, Embase, and Scopus were searched through January 17th, 2021. Studies reporting the ALBI grade and PHLF occurrence in HCC patients undergoing LR were included. The Odds Ratio (OR) prevalence with 95% confidence intervals (CI) was pooled, and the heterogeneity was expressed as I2. The quality of the studies was assessed using QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies). (3) Results: Seven studies met the inclusion criteria and were included in the analysis. A total of 5377 patients who underwent LR for HCC were considered, of whom 718 (13.4%) developed PHLF. Patients with ALBI grades 2 and 3 before LR showed increased rates of PHLF compared to ALBI grade 1 patients. The pooled OR was 2.572 (95% CI, 1.825 to 3.626, p < 0.001), with substantial heterogeneity between the studies (I2 = 69.6%) and no publication bias (Begg’s p = 0.764 and Egger’s p = 0.851 tests). All studies were at a ‘low risk’ or ‘unclear risk’ of bias. Univariate meta-regression analysis showed that heterogeneity was not dependent on the country of study, the age and sex of the participants, the definition of PHLF used, the rate of patients in Child–Pugh class A or undergoing major hepatectomy. (4) Conclusions: In this meta-analysis of published studies, individuals with ALBI grades of 2 and 3 showed increased rates of PHLF compared to ALBI grade 1 patients.
Galectin-3—A New Player of Kidney Damage or an Innocent Bystander in Children with a Single Kidney?
Authors: Latoch Eryk , Konończuk Katarzyna , Jander Anna , Trembecka-Dubel Elżbieta , Wasilewska Anna , Taranta-Janusz Katarzyna
Published: May 2021

The aim of this study was to evaluate the galectin-3 (Gal-3) level in children with a congenital solitary functioning kidney (cSFK) and determine its association with common renal function parameters. The study consisted of 68 children (49 males) with cSFK. We demonstrated that children with cSFK had a lower level of galectin-3 than that of healthy subjects (p < 0.001). No significant differences in serum cystatin C (Cys C) levels between the cSFK children and the reference group were found. The subjects with cSFK and reduced estimated glomerular filtration rate (eGFR) had significantly higher levels of Gal-3 and Cys C compared to those with normal eGFR (p < 0.05). Children with eGFR <60 mL/min/1.73 m2 showed significant statistical differences between the values of area under ROC curve (AUC) for Gal-3 (AUC 0.91) and Cys C (AUC 0.96) compared to that for creatinine level (AUC 0.76). Similar analyses carried out among cSFK children with eGFR <90 mL/min/1.73 m2 revealed an AUC value of 0.69 for Gal-3, 0.74 for Cys C, and 0.64 for creatinine; however, no significant superiority was shown for any of them. The receiver operating characteristic (ROC) analyses for identifying the SFK children among all participants based on the serum levels of Gal-3 and Cys C did not show any diagnostic profile (AUCs for Gal-3 and Cys C were 0.22 and 0.59, respectively). A positive correlation between the Gal-3 and Cys C concentrations was found (r = 0.39, p = 0.001). We demonstrated for the first time that Gal-3 might play an important role in the subtle kidney damage in children with cSFK. However, further prospective studies are required to confirm the potential applicability of Gal-3 as an early biomarker for kidney injury and possible progression to CKD.
De-Intensification of Antidiabetic Treatment Using Canagliflozin in Patients with Heart Failure and Type 2 Diabetes: Cana-Switch-HF Study
Authors: Pérez-Belmonte Luis M. , Ricci Michele , Sanz-Cánovas Jaime , Cobos-Palacios Lidia , López-Carmona María D. , Ruiz-Moreno M. Isabel , Millán-Gómez Mercedes , Bernal-López M. Rosa , Jansen-Chaparro Sergio , Gómez-Huelgas Ricardo
Published: May 2021

Canagliflozin is a sodium-glucose co-transporter 2 inhibitor that reduces glycemia as well as the risk of cardiovascular events. Our main objective was to analyze antidiabetic treatment de-intensification and the glycemic efficacy of replacing antidiabetic agents (excluding metformin) with canagliflozin in patients with heart failure and type 2 diabetes with poor glycemic control. In this observational, retrospective, real-world study, we selected patients treated with metformin in combination with ≥2 non-insulin antidiabetic agents or metformin in combination with basal insulin plus ≥1 non-insulin antidiabetic agent. Non-insulin antidiabetic agents were replaced with canagliflozin. Patients were followed-up on at three, six, and 12 months after the switch and a wide range of clinical variables were recorded. A total of 121 patients were included. From baseline to 12 months, the number of antidiabetic agents (3.1 ± 1.0 vs. 2.1 ± 0.8, p < 0.05), basal insulin dose (20.1 ± 9.8 vs. 10.1 ± 6.5 units, p < 0.01), and percentage of patients who used basal insulin (47.9% vs. 31.3%, p < 0.01) decreased. The proportion of patients who used diuretics also declined significantly. In addition, we observed improvement in glycemic control, with an increase in the proportion of patients with glycated hemoglobin <7% from 16.8% at three months to 63.5% at 12 (p < 0.001). Canagliflozin use was also beneficial in terms of body weight, blood pressure, heart failure status, functional class, and cardiovascular-renal risk. There were also reductions in the number of emergency department visits and hospitalizations for heart failure. Moreover, canagliflozin was well-tolerated, with a low rate of drug-related discontinuation. Mounting evidence from randomized controlled trials and real-world studies point to the beneficial profile of sodium-glucose co-transporter type 2 inhibitors such as canagliflozin in patients with heart failure.
Effect of Wearable Technology-Based Physical Activity Interventions on Breast Cancer Survivors’ Physiological, Cognitive, and Emotional Outcomes: A Systematic Review
Authors: Blount Daphne S. , McDonough Daniel J. , Gao Zan
Published: May 2021

This systematic review synthesized all randomized controlled trials (RCTs) and controlled trials examining the effects of wearable health technology-based physical activity interventions on physiological, cognitive, and emotional outcomes in breast cancer survivors (BCS). We searched NCBI, Academic Search Premier, EMBASE, Web of Science, PubMed, and Medline from inception to March 2021. We included studies which: (1) were RCTs or controlled trials ≥8 weeks in duration; (2) were peer-reviewed and published in English; (3) sampled BCS in full remission and had not received treatment for at least six months; (4) utilized wearable health technology (e.g., Fitbit, Garmin xGC30); and (5) examined physiological, emotional, and/or cognitive outcomes. Sixty-six studies were identified and 14 were included in the review. Most of the observed effects were statistically significant and those which employed multi-component interventions generally yielded greater effects. Overall, the use of wearable health technology reduced sedentary behavior and increased moderate-to-vigorous intensity physical activity. Further, increased moderate-to-vigorous intensity physical activity was observed to be associated with increased perceived cognition and higher cognitive performance. Multiple studies also observed significant improvements in attitude, worry, and anxiety. Overall, findings suggested wearable health technology-based physical activity interventions to be effective for improving physical activity, attitude, and cognitive functions and for reducing sedentary behavior, anxiety, and worry in BCS.
Radiological Cardiothoracic Ratio in Evidence-Based Medicine
Authors: Truszkiewicz Krystian , Poręba Rafał , Gać Paweł
Published: May 2021

The cardiothoracic ratio (CTR), expressing the relationship between the size of the heart and the transverse dimension of the chest measured on a chest PA radiograph, is a commonly used parameter in the assessment of cardiomegaly with a cut-off value of 0.5. A value of >0.5 should be interpreted as enlargement of the heart. The following review describes the current state of available knowledge in terms of contentious issues, limitations and useful aspects regarding the CTR. The review was carried out on the basis of an analysis of scientific articles available in the PubMed database, searched for using the following keywords: “CTR”, “cardiothoracic ratio”, “cardiopulmonary ratio”, “cardiopulmonary index”, and “heart-lung ratio”. According to the accumulated knowledge, the CTR can still be used as an important parameter that can be easily determined in establishing enlargement of the heart. However, an increased CTR does not directly relate to heart function. In the era following the development of diagnostic methods such as computed tomography, magnetic resonance imaging, and ultrasonography, CTR modifications based on these methods are used with varying clinical usefulness. It is important to consider the definition of the CTR and remember to base measurements on PA radiographs, as attempts to mark it in other projections face many limitations.
HGF, IL-1α, and IL-27 Are Robust Biomarkers in Early Severity Stratification of COVID-19 Patients
Authors: Tamayo-Velasco Álvaro , Martínez-Paz Pedro , Peñarrubia-Ponce María Jesús , de la Fuente Ignacio , Pérez-González Sonia , Fernández Itziar , Dueñas Carlos , Gómez-Sánchez Esther , Lorenzo-López Mario , Gómez-Pesquera Estefanía , Heredia-Rodríguez María , Carnicero-Frutos Irene , Muñoz-Moreno María Fe , Bernardo David , Álvarez Francisco Javier , Tamayo Eduardo , Gonzalo-Benito Hugo
Published: May 2021

Pneumonia is the leading cause of hospital admission and mortality in coronavirus disease 2019 (COVID-19). We aimed to identify the cytokines responsible for lung damage and mortality. We prospectively recruited 108 COVID-19 patients between March and April 2020 and divided them into four groups according to the severity of respiratory symptoms. Twenty-eight healthy volunteers were used for normalization of the results. Multiple cytokines showed statistically significant differences between mild and critical patients. High HGF levels were associated with the critical group (OR = 3.51; p < 0.001; 95%CI = 1.95–6.33). Moreover, high IL-1α (OR = 1.36; p = 0.01; 95%CI = 1.07–1.73) and low IL-27 (OR = 0.58; p < 0.005; 95%CI = 0.39–0.85) greatly increased the risk of ending up in the severe group. This model was especially sensitive in order to predict critical status (AUC = 0.794; specificity = 69.74%; sensitivity = 81.25%). Furthermore, high levels of HGF and IL-1α showed significant results in the survival analysis (p = 0.033 and p = 0.011, respectively). HGF, IL-1α, and IL 27 at hospital admission were strongly associated with severe/critical COVID-19 patients and therefore are excellent predictors of bad prognosis. HGF and IL-1α were also mortality biomarkers.
Prevalence and Clinical Characteristics of Dyssynergic Defecation and Slow Transit Constipation in Patients with Chronic Constipation
Authors: Tanner Samuel , Chaudhry Ahson , Goraya Navneet , Badlani Rohan , Jehangir Asad , Shahsavari Dariush , Malik Zubair , Parkman Henry P.
Published: May 2021

Patients with chronic constipation who do not respond to initial treatments often need further evaluation for dyssynergic defecation (DD) and slow transit constipation (STC). The aims of this study are to characterize the prevalence of DD and STC in patients referred to a motility center with chronic constipation and correlate diagnoses of DD and STC to patient demographics, medical history, and symptoms. High-resolution ARM (HR-ARM), balloon expulsion testing (BET) and whole gut transit scintigraphy (WGTS) of consecutive patients with chronic constipation were reviewed. Patients completed questionnaires describing their medical history and symptoms at the time of testing. A total of 230 patients completed HR-ARM, BET, and WGTS. Fifty (22%) patients had DD, and 127 (55%) patients had STC. Thirty patients (13%) had both DD and STC. There were no symptoms that were suggestive of STC vs. DD; however, patients with STC and DD reported more severe constipation than patients with normal transit and anorectal function. Patients with chronic constipation often need evaluation for both DD and STC to better understand their pathophysiology of symptoms and help direct treatment.
A Multiparametric MRI-Based Radiomics Analysis to Efficiently Classify Tumor Subregions of Glioblastoma: A Pilot Study in Machine Learning
Authors: Chiu Fang-Ying , Le Nguyen Quoc Khanh , Chen Cheng-Yu
Published: May 2021

Glioblastoma multiforme (GBM) carries a poor prognosis and usually presents with heterogenous regions of a necrotic core, solid part, peritumoral tissue, and peritumoral edema. Accurate demarcation on magnetic resonance imaging (MRI) between the active tumor region and perifocal edematous extension is essential for planning stereotactic biopsy, GBM resection, and radiotherapy. We established a set of radiomics features to efficiently classify patients with GBM and retrieved cerebral multiparametric MRI, including contrast-enhanced T1-weighted (T1-CE), T2-weighted, T2-weighted fluid-attenuated inversion recovery, and apparent diffusion coefficient images from local patients with GBM. A total of 1316 features on the raw MR images were selected for each annotated area. A leave-one-out cross-validation was performed on the whole dataset, the different machine learning and deep learning techniques tested; random forest achieved the best performance (average accuracy: 93.6% necrosis, 90.4% solid part, 95.8% peritumoral tissue, and 90.4% peritumoral edema). The features from the enhancing tumor and the tumor shape elongation of peritumoral edema region for high-risk groups from T1-CE. The multiparametric MRI-based radiomics model showed the efficient classification of tumor subregions of GBM and suggests that prognostic radiomic features from a routine MRI exam may also be significantly associated with key biological processes that affect the response to chemotherapy in GBM.
Short Plate with Screw Angle over 20 Degrees Improves the Radiologic Outcome in ACDF: Clinical Study
Authors: Jimenez Kathryn-Anne , Kim Jihyeon , Lee Jaenam , Lee Hwan-Mo , Moon Seong-Hwan , Suk Kyung-Soo , Kim Hak-Sun , Lee Byung-Ho
Published: May 2021

Background: Anterior cervical discectomy and fusion surgery is a common procedure for degenerative cervical spine. This describes allospacer and implant-related outcomes, comparing medium plate–low screw angle and short plate–high screw angle techniques. Methods: From January 2016 to June 2019, 79 patients who underwent ACDF were prospectively enrolled. Patients were divided, depending on the plate–screw system used: medium plate–low screw angle (12.3 ± 2.5 to 13.2 ± 3.2 degrees), and short plate–high screw angle (22.8 ± 5.3 to 23.3 ± 4.7 degrees). Subsidence, ALOD, and sagittal cervical balance were analyzed using lateral cervical X-rays. NDI and VAS scores were also evaluated. Results: Age for medium plate–low-angled screw group is 58.0 ± 11.3 years, and 55.3 ± 12.0 in the short plate–high-angled screw group (p-value = 0.313). Groups were comparable in mean NDI (p-value = 0.347), VAS (p-value = 0.156), C2–C7 SVA, (p-value = 0.981), and lordosis angle (p-value = 0.836) at 1-year post-surgery. Subsidence was higher in the medium plate–low-angled screw than in the short plate–high-angled screw (25% and 8.5%, respectively, p-value = 0.045). ALOD is also more common in the medium plate group (p-value = 0.045). Conclusion: Use of a short plate and insertion of high-angled screws (more than 20 degrees) has less chance of subsidence and occurrence of ALOD than the traditional technique of using medium plate and low angle.
Prevalence of Sleep Disordered Breathing in Patients with Primary Mitral Regurgitation Undergoing Mitral Valve Surgery
Authors: Gerçek Muhammed , Oldenburg Olaf , Gerçek Mustafa , Fox Henrik , Rudolph Volker , Puehler Thomas , Omran Hazem , Wolf Lisa Katharina , Hakim-Meibodi Kavous , Zeiher Andreas M. , Gummert Jan , Dimitriadis Zisis
Published: May 2021

Background: Sleep disordered breathing (SDB) is a frequent comorbidity in cardiac disease patients. Nevertheless, the prevalence and relationship between SDB and severe primary mitral regurgitation (PMR) has not been well investigated to date. Methods: A cohort of 121 patients with significant PMR undergoing mitral valve surgery were prospectively enrolled and received a cardiorespiratory single night polygraphy screening using ApneaLink before surgery. Eighty-two of them underwent a follow-up examination including a follow-up single-night sleep study 3 months after surgery. Results: The mean age of patients was 65.3 ± 12.0 years. Sixty patients (49.6%) were female. The mean EuroSCORE II was 2.5 ± 2.4%. Initially, 91 (75.2%) patients presented with SDB, among whom 50.4% (46 patients, 38.0% of total cohort) were classified as moderate to severe. These patients tended to require significantly longer postoperative intensive care and mechanical ventilation. Among the 82 patients who completed follow-up exams, mitral valve surgery led to a significant reduction in relevant SDB (20.7%). The apnea-hypopnea index (from 11/h [4;18] to 4/h [3;14] (p = 0.04)), the oxygenation-desaturation index (from 8/h [3;18] to 5/h [3;12] (p = 0.008)) as well as the saturation time below 90% (from 32 min [13;86] to 18 min [5;36] (p = 0.005)), were all shown to be improved significantly. Conclusion: The prevalence of SDB is very high in patients with severe primary mitral regurgitation and may contribute to postoperative complications and prolonged intensive care. A significantly reduced but still high prevalence of SDB was observed 3 months after mitral valve surgery, highlighting the bidirectional relationship between SDB and heart failure.
Impact of Kidney Failure on the Severity of COVID-19
Authors: Zarębska-Michaluk Dorota , Jaroszewicz Jerzy , Rogalska Magdalena , Lorenc Beata , Rorat Marta , Szymanek-Pasternak Anna , Piekarska Anna , Berkan-Kawińska Aleksandra , Sikorska Katarzyna , Tudrujek-Zdunek Magdalena , Oczko-Grzesik Barbara , Bolewska Beata , Czupryna Piotr , Kozielewicz Dorota , Kowalska Justyna , Podlasin Regina , Kłos Krzysztof , Mazur Włodzimierz , Leszczyński Piotr , Szetela Bartosz , Reczko Katarzyna , Flisiak Robert
Published: May 2021

Background: Patients with kidney failure are at an increased risk of progression to a severe form of coronavirus disease 2019 (COVID-19) with high mortality. The current analysis was aimed to assess the impact of renal failure on the severity of COVID-19 and identify the risk factors of the fatal outcome in this population. Methods: The analysis included patients from the SARSTer database, a national real-world study evaluating treatment for COVID-19 in 30 Polish centers. Data were completed retrospectively and submitted online. Results: A total of 2322 patients were included in the analysis. Kidney failure was diagnosed in 455 individuals (19.65%), of whom 373 presented moderate stage and 82 patients, including 14 dialysis individuals, presented severe renal failure. Patients with kidney failure were significantly older and demonstrated a more severe course of COVID-19. The age, baseline SpO2, the ordinal scale of 4 and 5, neutrophil and platelet count, estimated glomerular filtration rate, and C-reactive protein concentration as well as malignancy and arterial hypertension were the independent predictors of 28-day mortality in logistic regression analysis. Conclusions: Underlying kidney disease in patients with COVID-19 is among the leading factors associated with a higher risk of severe clinical presentation and increased mortality rate.
Genital Tract GAS Infection ISIDOG Guidelines
Authors: Donders Gilbert , Greenhouse Peter , Donders Francesca , Engel Ulrike , Paavonen Jorma , Mendling Werner
Published: May 2021

There has been an increasing worldwide incidence of invasive group A streptococcal (GAS) disease in pregnancy and in the puerperal period over the past 30 years. Postpartum Group A streptococci infection, and in particular streptococcal toxic shock syndrome (TSS) and necrotizing fasciitis, can be life threatening and difficult to treat. Despite antibiotics and supportive therapy, and in some cases advanced extensive surgery, mortality associated with invasive group A streptococcal postpartum endometritis, necrotizing fasciitis, and toxic shock syndrome remains high, up to 40% of postpartum septic deaths. It now accounts for more than 75,000 deaths worldwide every year. Postpartum women have a 20-fold increased incidence of GAS disease compared to non-pregnant women. Despite the high incidence, many invasive GAS infections are not diagnosed in a timely manner, resulting in potentially preventable maternal and neonatal deaths. In this paper the specific characteristics of GAS infection in the field of Ob/Gyn are brought to our attention, resulting in guidelines to improve our awareness, early recognition and timely treatment of the disease. New European prevalence data of vaginal GAS colonization are presented, alongside two original case histories. Additionally, aerobic vaginitis is proposed as a supplementary risk factor for invasive GAS diseases.
Utilizing a Terrestrial Laser Scanner for 3D Luminance Measurement of Indoor Environments
Authors: Kurkela Matti , Maksimainen Mikko , Julin Arttu , Rantanen Toni , Virtanen Juho-Pekka , Hyyppä Juha , Vaaja Matti Tapio , Hyyppä Hannu
Published: May 2021

We aim to present a method to measure 3D luminance point clouds by applying the integrated high dynamic range (HDR) panoramic camera system of a terrestrial laser scanning (TLS) instrument for performing luminance measurements simultaneously with laser scanning. We present the luminance calibration of a laser scanner and assess the accuracy, color measurement properties, and dynamic range of luminance measurement achieved in the laboratory environment. In addition, we demonstrate the 3D luminance measuring process through a case study with a luminance-calibrated laser scanner. The presented method can be utilized directly as the luminance data source. A terrestrial laser scanner can be prepared, characterized, and calibrated to apply it to the simultaneous measurement of both geometry and luminance. We discuss the state and limitations of contemporary TLS technology for luminance measuring.
Whole Genome Sequence of the Newly Prescribed Subspecies Oreochromis spilurus saudii: A Valuable Genetic Resource for Aquaculture in Saudi Arabia
Authors: Aljahdali Mohammed Othman , Molla Mohammad Habibur Rahman , Filfilan Wessam Mansour
Published: May 2021

Tilapia (Oreochromis spp.) have significant potential for aquaculture production around the world. There is an increasing demand among tilapia producers for strains with higher yields and for fish that can survive in highly saline water. Novel strains and consistent seedstock are critically important objectives for sustainable aquaculture, but for these required targets there is still not enough progress. Therefore, this study describes the genome sequence of Oreochromis spilurus to support the seawater culture of tilapia. The draft genome is 0.768 Gb (gigabases), with a scaffold N50 (the genome (50%) is in fragments of this length) of 0.22 Mb (megabases). The GC content is 40.4%, the heterozygosity rate is 0.35%, and the repeat content is 47.97%. The predicted protein-coding peptide encoded 51,642 and predicted 10,641 protein-coding genes in the O. spilurus genome. The predicted antimicrobial peptides were 262, bringing new hope for further research. This whole genome sequence provides new insights for biomedical and molecular research and will also improve the breeding of tilapia for high yields, resistance to disease, and adaptation to salt water.
The Use of Psychoacoustics in Marine Mammal Conservation in the United States: From Science to Management and Policy
Authors: Guan Shane , Brookens Tiffini
Published: May 2021

Underwater sound generated from human activities has been long recognized to cause adverse effects on marine mammals, ranging from auditory masking to behavioral disturbance to hearing impairment. In certain instances, underwater sound has led to physical injuries and mortalities. Research efforts to assess these impacts began approximately four decades ago with behavioral observations of large whales exposed to seismic surveys and rapidly progressed into the diverse field that today includes studies of behavioral, auditory, and physiological responses of marine mammals exposed to anthropogenic sound. Findings from those studies have informed the manner in which impact assessments have been and currently are conducted by regulatory agencies in the United States. They also have led to additional questions and identified information needed to understand more holistically the impacts of underwater sound, such as population- and species-level effects, long-term, chronic, and cumulative effects, and effects on taxa for which little or no information is known. Despite progress, the regulatory community has been slow to incorporate the best available science in marine mammal management and policy and often has relied on outdated and overly simplified methods in its impact assessments. To implement conservation measures effectively, regulatory agencies must be willing to adapt their regulatory scheme to ensure that the best available scientific information is incorporated accordingly.
Napthoquinones from Neocosmospora sp.—Antibiotic Activity against Acidovorax citrulli, the Causative Agent of Bacterial Fruit Blotch in Watermelon and Melon
Authors: Klomchit Anthikan , Calderin Jorge Daniel , Jaidee Wuttichai , Watla-iad Kanchana , Brooks Siraprapa
Published: May 2021

Bacterial fruit blotch (BFB) is a bacterial disease that devastates Cucurbitaceae crops worldwide, causing significant economic losses. Currently, there is no means to treat or control the disease. This study focused on exploring the antibacterial properties of endophytic fungi against Acidovorax citrulli (Aac), the causative agent of BFB. Based on disc diffusion, time kill and MIC microdilution broth assays, four endophytes showed promise in controlling Aac. Nonetheless, only one strain, Neocosmospora sp. MFLUCC 17-0253, reduced the severity of disease on watermelon and melon seedlings up to 80%. Structure analysis revealed production of several compounds by the fungus. Three of these secondary metabolites, including mixture of 2-methoxy-6-methyl-7-acetonyl-8-hydroxy-1,4-maphthalenedione and 5,8-dihydroxy-7-acetonyl-1,4-naphthalenedione, anhydrojavanicin, and fusarnaphthoquinones B exhibited antagonistic activity against Aac. The chemical profile data in planta experiment analyzed by LC-Q/TOF-MS suggested successful colonization of endophytic fungi in their host plant and different metabolic profiles between treated and untreated seedling. Biofilm assay also demonstrated that secondary metabolites of Neocosmospora sp. MFLUCC 17-0253 significantly inhibited biofilm development of Aac. To the best of our knowledge, secondary metabolites that provide significant growth inhibition of Aac are reported for the first time. Thus, Neocosmospora sp. MFLUCC 17-0253 possesses high potential as a biocontrol agent for BFB disease.
Understanding Consumers’ Purchase Intentions in Social Commerce through Social Capital: Evidence from SEM and fsQCA
Authors: Yang Xue
Published: May 2021

Social commerce has become a fiercely competitive environment. Understanding consumers’ purchase intentions can help social commerce platforms retain and attract more consumers. Social capital is one of the primary resources that plays a critical role in facilitating consumers’ purchase intentions in social commerce. Here, complex relationships between different dimensions of social capital are further clarified and its impact on consumers’ purchase intentions are discussed. Based on a survey of 302 social commerce users, this study utilizes an SEM and fsQCA approach to validate the effect of social capital on consumers’ purchase intentions. The SEM results reveal that the effect of structural social capital on consumers’ purchase intentions is fully mediated by relational and cognitive social capital. The fsQCA results confirm the significance of consumers’ social capital as determinants and provide the configurations that can lead to high purchase intentions. Though previous studies have discussed the factors influencing consumers’ purchase intentions, this study takes the first step toward enhancing the understanding of the configurations that link dimensions of social capital to consumers’ purchase intentions in s-commerce using fsQCA approach.
Children’s Rights in the Indonesian Oil Palm Industry: Improving Company Respect for the Rights of the Child
Authors: Pasaribu Stephany Iriana , Vanclay Frank
Published: May 2021

Although companies have many direct and indirect impacts on the lives of children, discussion of the responsibility of business to respect the rights of children has primarily focused on child labor. Using UNICEF’s Children’s Rights and Business Principles as a framework for our analysis, we considered the activities of oil palm plantation companies operating in Indonesia. Our data come from key informant interviews and reflection on two programs established to promote respect for children’s rights in the Indonesian palm oil industry: one by Pusat Kajian Perlindungan Anak (PKPA) (Center for Child Study and Protection); and one by the Roundtable on Sustainable Palm Oil (RSPO) in conjunction with UNICEF. We considered: how plantation company activities impacted children’s lives; how companies demonstrated respect for children’s rights; and how observance of children’s rights can be improved. We discuss four problematic issues: getting company commitments to children’s rights into policy and practice; having a strong business case for respecting human rights and children’s rights; contradictory objectives within companies; and complexities around children in the workplace. We argue that a children’s rights based approach should be applied to the activities of all organizations. This children’s rights lens is needed to overcome the invisibility of children in society and industry, and to address the root causes of human rights harms. We note that respecting children’s rights will likely contribute to getting a social license to operate and grow.
Natural Sulfurs Inhibit LPS-Induced Inflammatory Responses through NF-κB Signaling in CCD-986Sk Skin Fibroblasts
Authors: Sp Nipin , Kang Dong Young , Kim Hyoung Do , Rugamba Alexis , Jo Eun Seong , Park Jong-Chan , Bae Se Won , Lee Jin-Moo , Jang Kyoung-Jin
Published: May 2021

Lipopolysaccharide (LPS)-induced inflammatory response leads to serious damage, up to and including tumorigenesis. Natural mineral sulfur, non-toxic sulfur (NTS), and methylsulfonylmethane (MSM) have anti-inflammatory activity that may inhibit LPS-induced inflammation. We hypothesized that sulfur compounds could inhibit LPS-induced inflammatory responses in CCD-986Sk skin fibroblasts. We used Western blotting and real-time PCR to analyze molecular signaling in treated and untreated cultures. We also used flow cytometry for cell surface receptor analysis, comet assays to evaluate DNA damage, and ELISA-based cytokine detection. LPS induced TLR4 activation and NF-κB signaling via canonical and protein kinase C (PKC)-dependent pathways, while NTS and MSM downregulated that response. NTS and MSM also inhibited LPS-induced nuclear accumulation and binding of NF-κB to proinflammatory cytokines COX-2, IL-1β, and IL-6. Finally, the sulfur compounds suppressed LPS-induced ROS accumulation and DNA damage in CCD-986Sk cells. These results suggest that natural sulfur compounds could be used to treat inflammation and may be useful in the development of cosmetics.
Clinical Markers of Chronic Hypoxemia in Respiratory Patients Residing at Moderate Altitude
Authors: Fernández-Plata Rosario , Thirion-Romero Ireri , Nava-Quiroz Karol , Pérez-Rubio Gloria , Rodríguez-Llamazares Sebastián , Pérez-Kawabe Midori , Rodríguez-Reyes Yadira , Guerrero-Zuñiga Selene , Orea-Tejeda Arturo , Falfán-Valencia Ramcés , Pérez-Padilla Rogelio ,   on behalf of the Mexican Translational Research Hypoxemia Working Group
Published: May 2021

Supplemental oxygen (SO) increases survival in hypoxemic patients. In hypoxia, mammals respond by modulating O2-sensitive transducers that stabilize the transcription factor hypoxia-inducible factor-1-alpha (HIF-1α), which transactivates the genes that govern angiogenesis and metabolic pathways. Residing at high altitudes exposes millions of people to hypoxemia with potential adverse consequences on their health. We aimed to identify markers of hypoxemia that can be used in the evaluation of patients in addition to pulse oximetry and arterial blood gases, especially those that could respond after 1 month of oxygen use. We performed a prospective pilot study at 2240 m above sea level, with repeated measurements before and after (b/a) 1-month home oxygen therapy in 70 patients with lung diseases, of which 24/20 have COPD, 41/39 obstructive sleep apnea (OSA), and 5/2 with interstitial lung diseases (ILD), all of them having chronic hypoxemia, as well as 70 healthy subjects as controls. Proteins evaluated included HIF-1α, vascular endothelial growth factor (VEGF), and erythropoietin (EPO). Among the main results, we found that hypoxemic patients had normal levels of HIF-1α but increased EPO compared with healthy controls. VEGF levels were heterogeneous in the sample studied, similar to the control group in COPD, slightly increased in OSA, and decreased in fibrosis. With oxygen treatment, the HIF-1α and EPO decreased in COPD and OSA but not in fibrosis, and VEGF remained constant over time. In conclusion, erythropoietin and HIF-1α identified hypoxemia initially and responded to oxygen. In pulmonary fibrosis, HIF-1α, EPO, and VEGF increased with oxygen therapy, which is likely linked to the disease’s pathogenesis and clinical course rather than hypoxemia.
Spatio-Temporal Traffic Flow Prediction in Madrid: An Application of Residual Convolutional Neural Networks
Authors: Vélez-Serrano Daniel , Álvaro-Meca Alejandro , Sebastián-Huerta Fernando , Vélez-Serrano Jose
Published: May 2021

Due to the need to predict traffic congestion during the morning or evening rush hours in large cities, a model that is capable of predicting traffic flow in the short term is needed. This model would enable transport authorities to better manage the situation during peak hours and would allow users to choose the best routes for reaching their destinations. The aim of this study was to perform a short-term prediction of traffic flow in Madrid, using different types of neural network architectures with a focus on convolutional residual neural networks, and it compared them with a classical time series analysis. The proposed convolutional residual neural network is superior in all of the metrics studied, and the predictions are adapted to various situations, such as holidays or possible sensor failures.
DeepBlockShield: Blockchain Agent-Based Secured Clinical Data Management Model from the Deep Web Environment
Authors: Kim Junho , Kim Mucheol
Published: May 2021

With the growth of artificial intelligence in healthcare and biomedical research, many researchers are interested in large amounts of data in hospitals and medical research centers. Then the need for remote medicine services and clinical data utilization are expanding. However, since the misuse and abuse of clinical data causes serious problems, the scope of its use is bound to have a limited range physically and logically. Then a security-enhanced data distribution system for medical deep web environments. Therefore, in this paper, we propose a blockchain-based clinical data management model named DeepBlockshield to prevent information leakage between the deep web and the surface web. Blockchain supports data integrity and user validation to support data sharing in closed networks. Meanwhile, the agent performs integrity verification between the blockchain and the deep web and strengthens the security between the surface web and the deep web. DeepBlockShield verifies the user’s validity through the records of the deep web and blockchain. Furthermore, we wrap the results analyzed by the valid request into a web interface and provide information to the requester asynchronously. In the experiment, the block generation cycle and size on the delay time was analyzed for verifying the stability of the blockchain network. As a result, it showed that the proposed approach guarantees the integrity and availability of clinical data in the deep web environment.