bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of analgesic effects of doxepin cream in patients with knee osteoarthritis
Authors: Mazhari Hossein , Majmasanayea Mahnam , Eshraghi Azadeh , Eslami Neda
Published: January 2024

Background and purpose
Osteoarthritis is the most common type of arthritis, and knee osteoarthritis is one of the most important types, which causes symptoms such as pain and stiffness of the knee, followed by a weakening of physical performance and a decrease in quality of life. Among the complementary treatments that are of interest are new and optimal drugs that can reduce the pain and discomfort of patients with fewer side effects. We aim to investigate the effect of doxepin cream in reducing pain in patients with knee osteoarthritis.
Methods
In this double-blind clinical trial, 60 patients with knee osteoarthritis were selected and randomly divided into 3 groups of 20 people. The first group used placebo cream 2 times a day, the second group used 5% doxepin cream 2 times a day, and the third group used diclofenac 1% topical gel 2 times a day. All three groups used 250–500 mg naproxen tablets orally daily. Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and Visual Analogue Scale (VAS) questionnaires were checked at the beginning of the study and six weeks after the start of treatment. Improvement of physical function and reduction of pain is considered as a response to treatment.
Results
This study showed that after the doxepin intervention, in second group there was a significant difference in knee pain (P < 0.005), dryness during the day (P < 0.05), morning dryness (P < 0.05), and physical performance (P < 0.05) between the groups. In the two groups receiving doxepin cream and diclofenac gel, there was a significant reduction in symptoms (pain and stiffness of the knee) and an improvement in physical performance.
Conclusion
The topical form of doxepin, which was prepared as a cream, reduced knee pain, morning dryness, and dryness during the day and improved the physical performance of patients with primary knee osteoarthritis. It seems that the reduction of patient symptoms is due to the inhibitory effects on NMDA(N-methyl-D-aspartate) receptors, as well as the inhibitory effects on noradrenaline and 5-hydroxytryptamine reabsorption, as well as the inhibition of sodium voltage channels.
Assessing the Preservation Effectiveness: A Comparative Analysis of Plasma Activated Water and Various Preservatives on Capsicum annuum L. (Jalapeño and Pusa Jwala)
Authors: Rathore Vikas
Published: January 2024

The study investigated the efficacy of plasma-activated water (PAW) in preserving green chillies (jalapeño and pusa jwala) and compared it with various household cleaners' solutions. PAW was prepared using a pencil plasma jet with air as the plasma forming gas. The results of visual analysis revealed that PAW-treated chillies maintained a better appearance even after 21 days, exhibiting significantly lower spoilage compared to control and cleaners. Physicochemical properties of PAW, including acidity and oxidizing potential, increased with plasma treatment time, influencing reactive species concentration. PAW demonstrated antimicrobial properties, effectively reducing microbial growth and spoilage on chillies over the storage period.
Physical attributes, such as weight loss and firmness, were evaluated, with PAW-treated chillies exhibiting lower weight loss and higher firmness, indicating better membrane integrity and moisture retention. Microbial resistance was notably higher in PAW-treated chillies compared to control and cleaners. CIELAB color analysis revealed that PAW-treated chillies retained greenness and color freshness, outperforming control and cleaners. Sensory evaluation, including visual inspection, smell, taste, and touch, consistently favored PAW-treated chillies, emphasizing their superior shelf-life extension.
Biochemical analysis showed that PAW-treated chillies maintained or enhanced nutritional attributes such as soluble sugar, protein, and ascorbic acid concentrations. Phenol concentration (antioxidant activity) remained stable across treatments. Overall, the study underscores the positive impact of PAW treatment on preserving the membrane integrity, antimicrobial resistance, sensory quality, and nutritional attributes of green chillies, making it an alternative for extending their shelf life.
Estimation of Precipitation During Kiremt and Belg Seasons And The Water Vapor Flux Convergence Layers in Ethiopia
Authors: Kebede Tegegne , Kebede Abebe , Ayele Kefyalew
Published: January 2024

This paper aimed to investigate the most important moisture-bearing layers in VIWVF among different monthly intervals over the Ethiopian atmosphere based European Centre for Medium-Range Weather Forecasts (ECMWF) averaged reanalysis zonal and meridional wind data and specific humidity data with the time coverage from 1991-2019 with 0.25° by 0.25° spatial resolution in various types of pressure levels from 1000hpa to 300hpa and ERA5-Land monthly averaged reanalysis data for precipitation. The Ethiopian troposphere is classified into four layers clustering by the Euclidean Distance method. VIWVF and specific humidity are higher in the lower pressure levels and decrease at higher altitudes. The moisture sources during the Belg season are the Indian Ocean and the Arabian Sea are the main sources; the ML1 and ML2 are the interesting layers and good moisture convergence cores for Belg Season rainfall, especially in March and April. During the Kiremt season, VIWVF sources are from the South Indian Ocean and the Mediterranean Sea through the Red Sea, with high moisture flux convergence observed in Lr. L and ML1 tropospheric layers (1000hpa-850hpa and 825hpa-750hpa), in July and August. Significant positive correlations between Belg VIWVF and precipitation were recognized in the layer 700hpa-600hpa over Northeastern highlands, Bale, Harar, and Yirgacheffe, whereas significant positive correlation with Kiremt rainfall over central-western to northwestern Ethiopia in July and August at 1000-850hpa and 825-750hpa. This research targeted to identify the most important moisture-centered layers, especially in the Summer(main) and Spring (second) rainy seasons through VIWVF and its association with precipitation to forecast climate and weather impacts over Ethiopia’s atmosphere.
A Scalable Total Synthesis of Deoxyrhapontigenin from Low-Cost α-Resorcylic Acid
Authors: Rego Yuri , de Fátima Ângelo
Published: January 2024

A scalable total synthesis for deoxyrhapontigenin (DRG) was successfully accomplished using low-cost α-resorcylic acid as a starting material. Our approach initiates with the protection of phenolic groups using methoxymethyl, resulting in the synthesis of a derivative of the expensive 3,5-hydroxybenzaldehyde, a critical component for Wittig and Perkin approaches in stilbenoid synthesis. Additionally, the corresponding olefin for Heck reaction and formal synthesis of resveratrol were produced in over 85% yield. The synthesis of deoxyrhapontigenin was accomplished in seven steps from the initial carboxylic acid, yielding a product with an average purity higher than 98%, as confirmed by quantitative nuclear magnetic resonance (NMR) analysis.
Feasibility of financing nature-based solutions for water security through water tariffs: Evidence from South Africa
Authors: du Plessis Nicola S. , Turpie Jane K. , Letley Gwyneth K.
Published: January 2024

In many countries, catchment restoration is underfunded. This study aims to address whether household water pricing could be used as a mechanism for securing funds for catchment restoration. The objectives were to determine households' willingness to pay (WTP) for their existing water use, investigate whether institutional trust and municipal satisfaction influenced WTP, and establish whether aggregate consumer surplus at the municipal scale could cover the costs needed to finance catchment restoration. Surveys were conducted on 502 households in three metropolitan municipalities in the City of Cape Town, eThekwini, and Nelson Mandela Bay. Contingent valuation revealed that average WTP for water was between 12 and 137% more and 32 and 73% more than what households currently pay for water per month in the City of Cape Town and eThekwini, respectively. Satisfaction with municipal service delivery positively influenced WTP, while institutional trust did not. The City of Cape Town, based on the aggregate WTP from the higher income categories, consumer surplus was 779 million South African Rand (ZAR)/year, more than double the estimated cost required to restore the catchment areas supplying water to the city over 30 years. In eThekwini, consumer surplus was equal to the amount needed over 30 years (250 million ZAR/year). These results demonstrate the significant potential to raise water tariffs for higher income households in metropolitan municipalities.
Phytochemicals as Potential Lead Molecules against Hepatocellular
Carcinoma
Authors: Rayginia Tennyson Prakash , Keerthana Chenicheri Kizhakkeveettil , Shifana Sadiq Chembothumparambil , Pellissery Maria Joy , Abhishek Ajmani , Anto Ruby John
Published: January 2024

:

Hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer,
accounting for 85-90% of liver cancer cases and is a leading cause of cancer-related mortality
worldwide. The major risk factors for HCC include hepatitis C and B viral infections,
along with chronic liver diseases, such as cirrhosis, fibrosis, and non-alcoholic
steatohepatitis associated with metabolic syndrome. Despite the advancements in modern
medicine, there is a continuous rise in the annual global incidence rate of HCC, and
it is estimated to reach >1 million cases by 2025. Emerging research in phytomedicine
and chemotherapy has established the anti-cancer potential of phytochemicals, owing to
their diverse biological activities. In this review, we report the major phytochemicals
that have been explored in combating hepatocellular carcinoma and possess great potential
to be used as an alternative or in conjunction with the existing HCC treatment modalities.
An overview of the pre-clinical observations, mechanism of action and molecular
targets of some of these phytochemicals is also incorporated.
Mechanism of Tonifying Spleen-lung Recipe in the Treatment of Chronic Bronchitis Based on Network Pharmacology and Observational Data
Authors: Wu Hongjin , Li Shenguang , Du Xiaomei , Zhu Kaigong , Li Jing
Published: January 2024

Background:

Chronic bronchitis is a type of common chronic inflammatory respiratory
disease, which is mainly characterized by chronic cough and expectoration. Clinical practice
and experimental research have shown that the modified tonifying spleen-lung method has significant
preventive and therapeutic effects on chronic lung diseases, but the mechanism of TSLR
in the treatment of chronic bronchitis are not yet clear.

Objective:

To explore the mechanism of tonifying spleen-lung recipe (TSLR) in the treatment of
chronic bronchitis (CB) through network pharmacology combined with observational studies.

Materials and Methods:

The effective components, core targets and signaling pathways of
TSLR in the treatment of chronic bronchitis were obtained using network pharmacology. One
hundred and thirty-seven elderly CB patients were selected as the observational group who were
treated by TSLR, and 67 no-CB cases from the Physical Examination Center were selected as the
control group. We compared the levels of inflammatory parameters between patients before and
after TSLR treatment, and after treatment group with the control group were also compared.

Results:

The key effective components of TSLR selected by network pharmacology included
quercetin, kaempferol, luteolin, and nobiletin, and the core targets involved HSP90AA1, AKT1,
JUN, MAPK1, IL6, MAPK3, MAPK14, STAT1, NFKB1, and CDKN1. KEGG pathway enrichment
analysis revealed that the TNF signaling pathway, PI3K-AKT and AGE-RAGE signaling
pathways might play a key role in the treatment of CB. The observation study demonstrated
that compared with the control group, the levels of WBC, NEU, NLR, PCT, and CRP in the research
group after TSLR treatment were increased. Although the levels of WBC, NEU, NLR,
and PCT in the research group after TSLR treatment were higher than those in the control group,
the above indicators trend tended towards the control group, and there was no significant difference
in CRP indicators between the control group and after treatment group.

Conclusion:

TSLR had a good therapeutic effect on chronic bronchitis patients, which might be
related to the fact that the natural active components in TSLR inhibit inflammation by regulating
the expression of proteins related to PI3K-AKT and TNF signaling pathways.
Study on the Mechanism of Notch Pathway Mediates the Role of Lenvatinib-resistant Hepatocellular Carcinoma Based on Organoids
Authors: Feng Weiqing , Zhang Haixiong , Yu Qing , Yin Hao , Ou Xiaowei , Yuan Jie , Peng Liang
Published: January 2024

Background:

The emergence of treatment resistance has hindered the
efficacy of targeted therapies used to treat patients with hepatocellular carcinoma
(HCC).

Objective:

This study aimed to explore the mechanism of organoids constructed from
lenvatinib-resistant HCC cells.

Methods:

Hep3B cell and human HCC organoids were cultured and identified using
hematoxylin and eosin staining and Immunohistochemistry. Lenvatinib-sensitive/
resistant Hep3B cells were constructed using lenvatinib (0, 0.1, 1, and 10 μM) and
lenvatinib (0, 1, 10, and 100 μM). qRT-PCR and flow cytometry were utilized to determine
HCC stem cell markers CD44, CD90, and CD133 expressions. Transcriptome
sequencing was performed on organoids. Western blot evaluated Notch pathwayrelated
proteins (NOTCH1 and Jagged) expressions. Furthermore, DAPT, an inhibitor
of the Notch pathway, was used to investigate the effects of lenvatinib on resistance or
stemness in organoids and human HCC tissues.

Results:

The organoids were successfully cultivated. With the increase of lenvatinib
concentration, sensitive cell organoids were markedly degraded and ATP activity was
gradually decreased, while there was no significant change in ATP activity of resistant
cell organoids. CD44 expressions were elevated after lenvatinib treatment compared
with the control group. KEGG showed that lenvatinib treatment of organoids
constructed from Hep3B cells mainly activated the Notch pathway. Compared with the
control group, NOTCH1 and Jagged expressions elevated, and ATP activity decreased
after lenvatinib treatment. However, ATP activity was notably decreased after DAPT
treatment. Moreover, DAPT inhibited lenvatinib resistance and the increase in the
expressions of CD44 caused by lenvatinib. Besides, 100 μM lenvatinib significantly
inhibited the growth and ATP activity of human HCC organoids, and DAPT increased
the inhibitory effect of lenvatinib.

Conclusion:

Lenvatinib regulated resistance and stemness in organoids via the Notch
pathway.
Effect of Per and Poly-Fluoroalkyl Substances on Pregnancy and Child Development
Authors: Kilari Thanuja , Suresh Ankul Singh , Begum Rukaiah F. , Singh Anuragh , Venkkatesh Pravin , Vellapandian Chitra
Published: January 2024

Background:

Childhood obesity is significantly influenced by maternal exposure to Per
and Poly-Fluoroalkyl Substances (PFAS) during pregnancy. PFAS exposure occurs through the
Peroxisome Proliferator-Activated Receptor (PPAR-γ) receptor, leading to increased fat deposition
and profound health effects in child growth and development. Despite ongoing investigations,
the relationship between maternal serum PFAS concentration and child obesity requires further exploration.

Objective:

This study aimed to review the possible effects of Per and poly-fluoroalkyl substances
exposure and their mechanism in overweight/obese children from pregnant ladies.

Methods:

A detailed literature survey was conducted using online databases, including Science Direct,
Google Scholar, Scopus, Cochrane, and PubMed. The study focused on the diverse effects of
PFAS on maternal and child health, with particular emphasis on neurological complications.

Results:

Child growth development depends upon breastfeeding and placenta health, which is disrupted
by PFAS exposure, ultimately destroying the body mass index of the child. Neurotoxicity
testing utilized the SH-SY5Y human-derived cell line as an in vitro model, revealing PFAS-induced
increases in adipocyte number, reduced cell size, altered lipid conglomeration, increased
adiposity, and changes in liver function. in vivo studies in mice and human cell lines indicated
PPAR-γ and ER-α activation, leading to adiposity and weight gain through Estrogen signaling and
Lipid metabolism. PFAS concentrations positively correlated in maternal sera, analyzed by liquid
chromatography/quadrupole mass spectrometry.

Conclusion:

PFAS, with a long half-life of 3.5-8.5 years, is commonly found in the serum of pregnant
women, crossing the placenta barrier. This exposure disrupts placental homeostasis, negatively
impacting mechanisms of action and potentially leading to deterioration in pregnancy and child
health. Further research is needed to comprehensively understand the complex interplay between
PFAS exposure and its implications for maternal and child well-being.
Exploring the Therapeutic Potential of Alkaloids in Alzheimer's Disease
Management
Authors: Singh Randhir , Rani Nidhi , Kaur Rajwinder , Chahal Geeta , Kumar Praveen , Kaur Gagandeep
Published: January 2024

Background::

Alkaloids are important phytoconstituents obtained from various plant
sources. The study's primary goal is to assess the anti-Alzheimer potential of alkaloids using a molecular
docking study. Alzheimer's disease (AD) is considered a gradual decline in memory, reasoning,
decision-making, orientation to one's physical surroundings, and language.

Materials and Methods:

The main target i.e. acetylcholinesterase proteins was selected for the molecular
docking study.

Results::

The structures of various alkaloids were drawn using Chem Draw Software, PDB was retrieved
from the RCSB PDB database, and molecular docking study was performed on Molergo Virtual
Docker. The potential alkaloids were identified with anti-Alzheimer potency.

Conclusion::

Reserpine, vinblastine, ergotamine, and tubocurarine were found to exhibit potential
anti-Alzheimer potency.
Cambios en uso de suelo y vegetación en tres cuencas de México con modelos de Markov
Authors: Von Thaden Ugalde Juan José , Lithgow Debora , Revollo-Fernández Daniel A. , Salazar-Vargas María del Pilar , Rodríguez de los Santos Aram
Published: January 2024

En las últimas décadas, la actividad antropogénica ha impulsado la deforestación o sustitución de los ecosistemas naturales, en particular los bosques, lo que a su vez ha reducido su capacidad para brindar una gama de servicios ambientales importantes para asegurar el bienestar humano. El entender cómo es la dinámica de cambio de uso de suelo e identificar sus principales impulsores es clave para la generación de estrategias específicas para cada región. El objetivo principal de este estudio fue comprender y predecir las dinámicas de cambio de uso de suelo y vegetación en tres cuencas de México (Ameca-Mascota en Jalisco, Del Carmen en Chihuahua y Jamapa en Veracruz) con diferentes niveles de deforestación, a lo largo de un período de 25 años. Esto incluyó el análisis de tendencias históricas, la identificación de factores biofísicos y socioeconómicos que contribuyen a la deforestación, y la evaluación de escenarios futuros de deforestación para los años 2026 y 2041 utilizando cadenas de Markov. Los resultados sugieren que la dinámica de cambio de uso suelo y vegetación en los últimos 25 años tiende hacia a la deforestación, y las proyecciones a futuro sugieren que esta dinámica de deforestación no va a cambiar para los años del 2026 y 2041. En las tres cuencas los dos impulsores más significativos fueron la distancia a caminos y al borde de la vegetación, lo que sugiere que la deforestación es mayor en zonas cercanas a los caminos y a los bordes de la vegetación. Esta información es clave para generar estrategias de conservación y restauración en las tres cuencas para revertir la tendencia de deforestación actual y futura.
Intertwined gender inequality in Desy Anwar’s "Growing Pains"
Authors: Zulfie Vivian , Kusumayanti Dina Dyah
Published: January 2024

Rooted within structures of patriarchy and modern life, gender equality seems still far from achieved. Providing social issues like gender inequality, literary works become reliable proof to portray subordination or discrimination against women. Thus, this study aspires to strive for women empowerment and re-educating men expectantly to tackle the problems of gender inequality. Desy Anwar’s Growing Pains is interlaced with gender issues in five chapters. This research aims to unveil a range of gender conflicts and the efforts of the female main characters to overcome the hardships in life. Descriptive criticism is employed as a method of analysis. Following Lazar’s Feminist Critical Discourse Analysis (2014), the linguistic data in the form of lexical choices, phrases, and clauses are first identified based on the language features indicating gender inequality or violence. Eckert and McConnell-Ginet’s language theory (2013) is applied in unraveling the details of linguistic evidence. Then, interpreting the discursive logic is correlated with the cultural realm of the novel Hence, the findings yield that all the selected lexicons, phrases, and clauses of the novel construct the meanings of gender issues. Socio-cultural experiences represent forms of gender-based violence such as asymmetrical family systems, misogynistic practices, gender-identity threatening, deviant female promiscuity, and cruel motherhood portrayal. The symbolic and psychological impacts are also identified, referring to post-patriarchal regimes. Although there seems to be effortful survival in masculine domination, both internal and external factors are in support of constructed gender inequalities. Eventually, all the female characters are demonstrated as the vulnerably subordinated subjects of neoliberal hegemony. This research fervently aims to recall the awareness of symbolic gender violence due to ongoing powers that halt the emergence of gender equality and reshape it into hegemonic strategies.Keywords: hegemony, inequality, misogyny, patriarchy, symbolic violence
Effective teaching strategies in "The Ron Clark Story" for teaching English as a foreign language
Authors: Floriasti Tri Wahyuni , Destyana Renasya
Published: January 2024

The need for improved language education approaches is critical given the current globalized world's growing demand for English language competency. Barriers based on language might prevent people from communicating and limit their chances. The goal of this study is to address the urgent need for creative and practical approaches to teaching foreign languages in order to enable students to get the language proficiency necessary for success in a globalized and multicultural society. The study explores effective teaching strategies in teaching and learning English as a foreign language, drawing insights from the movie "The Ron Clark Story." The research examines the alignment between the teaching strategies depicted in the movie and existing literature, specifically focusing on cognitive thinking and behavior. The research findings emphasize the significance of engaging in active social interactions, critical thinking, research, and evaluation to promote cognitive growth and improve language acquisition. The movie effectively showcases the positive impact of teaching strategies such as modeling, positive reinforcement, and structured learning on students' behavior. These findings imply that educators can implement these strategies to enhance cognitive growth and language learning and create a positive and engaging learning environment for English language learners in the classroom. The movie is a valuable resource and inspiration for educators seeking innovative approaches to teaching English as a foreign language. This research contributes to the existing body of knowledge on effective teaching strategies and their impact on cognitive thinking and behavior in the context of English language education.
Developing communicative LMS-based English for specific purposes learning materials with CLIL approach
Authors: Virginiya Putu Tika , Natalia Sang Ayu Made Krisna Dewi , Anggraheni Raden Roro Rieta
Published: January 2024

Teaching English for Specific Purposes in the age of technological innovation necessitates a new strategy for communicative contexts that incorporates technology into the teaching and learning process. CLIL (Content and Language Integrated Learning) approach is considered a suitable approach in which students not only understand the content and context of situations that are practiced following the actual conditions in the industry but are also expected to be fluent in two-way communication. This study aims to develop an LMS-based communicative teaching material with the CLIL approach. Using the Research and Development method by applying the ADDIE model, 60 students were involved as the research subject, two lecturers were observed and interviewed, and three expert judges evaluated the quality of the communicative LMS-based materials developed. The results show that the developed materials were of excellent quality, with a mean score of 4.98 from the three expert judges, and the students have perfect perceptions towards both the LMS’s features in English learning materials and the use of the CLIL approach in English learning materials. Pedagogically, it is advised that if internet access is unavailable, the lecturers figure out a means to get over last-minute obstacles.
Enhancing Health Equity by Predicting Missed Appointments in Health Care: Machine Learning Study
Authors: Yang Yi , Madanian Samaneh , Parry David
Published: January 2024

Background

The phenomenon of patients missing booked appointments without canceling them—known as Did Not Show (DNS), Did Not Attend (DNA), or Failed To Attend (FTA)—has a detrimental effect on patients’ health and results in massive health care resource wastage.

Objective

Our objective was to develop machine learning (ML) models and evaluate their performance in predicting the likelihood of DNS for hospital outpatient appointments at the MidCentral District Health Board (MDHB) in New Zealand.

Methods

We sourced 5 years of MDHB outpatient records (a total of 1,080,566 outpatient visits) to build the ML prediction models. We developed 3 ML models using logistic regression, random forest, and Extreme Gradient Boosting (XGBoost). Subsequently, 10-fold cross-validation and hyperparameter tuning were deployed to minimize model bias and boost the algorithms’ prediction strength. All models were evaluated against accuracy, sensitivity, specificity, and area under the receiver operating characteristic (AUROC) curve metrics.

Results

Based on 5 years of MDHB data, the best prediction classifier was XGBoost, with an area under the curve (AUC) of 0.92, sensitivity of 0.83, and specificity of 0.85. The patients’ DNS history, age, ethnicity, and appointment lead time significantly contributed to DNS prediction. An ML system trained on a large data set can produce useful levels of DNS prediction.

Conclusions

This research is one of the very first published studies that use ML technologies to assist with DNS management in New Zealand. It is a proof of concept and could be used to benchmark DNS predictions for the MDHB and other district health boards. We encourage conducting additional qualitative research to investigate the root cause of DNS issues and potential solutions. Addressing DNS using better strategies potentially can result in better utilization of health care resources and improve health equity.
Current Status and Prospect of Research on Foreign Language Learning Enjoyment
Authors: Yang Yuting
Published: January 2024

This study adopts the literature research method to analyze a total of 20 empirical studies on foreign language learning enjoyment from 2018 to 2023, and the results show that foreign language enjoyment positively predict foreign language learning effectiveness, and foreign language enjoyment plays a mediating role between second language grit and other factors such as communicative willingness. However, most of the previous studies focus on college students from urban areas, and the research methods are mainly quantitative, with few tracking studies and qualitative interviews. Thus, future research can pay more attention to lower grade students from rural areas, and increase observational or tracking studies to enhance the research reliability.
Socio-cultural (re) presentations of Wall Street in Tom Wolfe’s The Bonfire of the Vanities (1987) and Michael Lewis’s Liar’s Poker (1989)
Authors: Ndao Dr. Souleymane
Published: January 2024

Wall Street's historical journey, from the Buttonwood Agreement to the Great Depression and the latter half of the 20th century, unfolds as a dynamic tale of growth and challenges. The Agreement of 1792 beneath a buttonwood tree marked a transformative moment, laying the foundation for organized trading and shaping Wall Street into a global financial hub. The 19th century saw the rise of diverse financial institutions, solidifying Wall Street's role in the American financial system. Despite facing challenges like the Panic of 1873, Wall Street demonstrated resilience, becoming instrumental in financing the nation's industrial expansion. The Gilded Age propelled Wall Street to global prominence, with the emergence of the New York Stock Exchange contributing to the myth of the "Master of the Universe." The Roaring Twenties brought both prosperity and societal flaws, as the pursuit of material wealth and excess sowed the seeds for moral decay. Understanding this historical context is crucial for exploring evolving cultural representations. Focusing on literature from the 1980s, specifically Tom Wolfe's The Bonfire of the Vanities (1987) and Michael Lewis's Liar's Poker (1989), this study adopts a structuralist approach. Through evaluating symbols, archetypes, and cultural codes, the analysis contributes to a nuanced understanding of the intricate relationship between finance and broader societal and cultural contexts.
Evaluation and selection sunflower hybrids for seed yield under different environmental conditions of Punjab
Authors: Qamar Rizwana , Habib Sajida
Published: January 2024

Estimation of environmental effects are essential for selection of genotypes for general cultivation at various regions. With this aim a research trial was conducted during spring, 2021 to evaluate suitability and stability of eight sunflower hybrids developed by Oilseeds Research Institute, Faisalabad (ORI, FSD), against two check hybrids at different locations in Punjab. The prime objective of this experimentation was to evaluate and classified sunflower hybrids by multivariate method of principal component analysis (PCA) using the GGE biplot software for their yield. Statistix 8.1 was used to analyze the recorded data and GGE biplot was used for Principal Component Analysis and pictorial demonstration of data. Analysis of variance showed presence of significant variation between hybrids, environments and their interaction. Sunflower hybrid FH-555 showed highest mean yield in Punjab followed by FH-741. The first two principal components present 76% of the total variation. Results indicated that the hybrid FH-740 and FH-751 are best suitable for Multan, hybrid FH-741 and FH-732 for Muzaffargarh, FH-555 for RajanPur, Hysun-33, FH-331, FH-675, FH-648 and S-278 for Faisalabad region. The hybrid FH-741 is highly stable hybrid in yield performance across the environments. The case of this hybrid (FH-741) was submitted in Variety Evaluation Committee (VEC) and got approval for general cultivation in whole Pakistan during 2022. Again the case was submitted in Punjab Seed Council (PSC) and got approval for general cultivation in Punjab during 2023. Keywords: Genetic variability, micro yield trial, stability, seed yield, statistix 8.1.
Design of SUPRA-SAE Student Version (A Review)
Authors: Handa C.C.
Published: January 2024

Abstract: The most important part of any vehicle is the Chassis. The chassis is the support system for all components in the vehicle. It is responsible for supporting all functional systems of a vehicle and accommodates the driver in the cockpit. Therefore, its design must sustain the weight of the components. Designing a chassis for driver’s safety is always been a concern, especially for a race car. In this report, a few techniques are mentioned on how to analyze a formula student race car chassis to ensure its structural stability for the driver’s safety
Memahami Hadis-Hadis Misoginis dengan Pendekatan Spirit Ayat-Ayat Al-Qur’an
Authors: Fauziah Mira
Published: January 2024

A refreshment of the understanding of misogynistic hadiths is absolutely necessary. The reason is not primarily to align with the demands of modern intellectual development, but rather to free the understanding from gender prejudices. As modern Islamic thinkers have demonstrated, the hadiths in question do not actually emphasize superiority or inferiority based on gender, which in classical interpretations have been embellished with explanations and additions that marginalize women. Consequently, the understanding of these hadiths merely accommodates the socio-historical facts that have sidelined women's rights. This interpretation of hadiths becomes a powerful religious tool for disempowering women. This phenomenon is clearly a contradiction. On one hand, the Qur'an strongly emphasizes the values of justice, equality, and freedom. But on the other, the understanding of hadiths has obstructed these fundamental values.

ABSTRAK

Penyegaran pemahaman terhadap hadis-hadis misoginis mutlak dilakukan. Alasannya bukan terutama untuk menyesuaikan dengan tuntutan perkembangan dunia pemikiran modern, melainkan untuk membebaskan pemahaman dari prasangka jender. Seperti telah ditunjukkan oleh para pemikir Islam modern, hadis-hadis yang sebenarnya tidak menekankan superioritas inferioritas atas dasar jenis kelamin yang dalam tafsir klasik telah dibumbui penjelasan dan tambahan yang memarjinalisasikan perempuan. Sehingga, pemahaman hadis bersifat semata-mata mengakomodasi fakta sosiologis-historis yang telah menyingkirkan hak-hak perempuan. Pemahaman hadis menjadi alat religius sangat ampuh untuk tidak memberdayakan perempuan. Fenomena ini jelas merupakan sebuah kontradiksi. Di satu sisi al-Qur`an sangat menekankan nilai-nilai keadilan, persamaan dan kebebasan. Tetapi di sisi lain, pemahaman terhadap hadis telah menghalangi nilai-nilai utama itu.
Urgensitas Pembelajaran Ilmu Hadis Di Era Digital
Authors: Wahid Abdul , Junida Junida
Published: January 2024

Hadith as the words of the Prophet SAW. from time to time is very interesting to study and study. Along with the rapid development of technology, it also influences the development of hadith studies. In this digital era, there are many hadith books that fill the media space. Technological developments have given birth to hadiths that can exist on social media. Various applications have been presented with attractive packaging so that the hadith problem which was previously done manually by having to open volumes of hadith books, now has a hadith application that makes it easier for users to find the hadith they need, even in the application there is also content -content such as sanad and matan. Among the hadith applications that have contributed to coloring in the digital era are: Maktabah Syamilah, Lidwa Pusaka, Gawamil Kaleem, Mausyu'ah and so on. Seeing the development of hadith itself which is now in the digital era, we should know how to take advantage of it. moreover, these academics are so enthusiastic about developing hadith studies in this digital era. Our role as regeneration is only to maximize it and develop it in order to develop the hirroh of hadith studies towards a golden era again.

ABSTRAK

Hadis sebagai sabda Nabi SAW. dari masa ke masa sangat menarik untuk dikaji dan dipelajari. Seiring dengan perkembangan teknologi yang melaju pesat juga mempengaruhi tehadap perkembangan kajian hadis. Di era digital ini, banyak ditemui kitabkitab hadis memenuhi ruang media. Perkembangan teknologi telah melahirkan hadis bisa eksis di media sosial. Berbagai aplikasi telah disajikan dengan kemasan menarik sehingga problem hadis yang tadinya dilakukan secara manual dengan harus membuka kitab-kitab hadis yang berjilid-jilid, kini telah hadir aplikasi hadis sehingga memudahkan bagi pengguna dalam mencari hadis yang dibutuhkan, bahkan di dalam aplikasi tersebut juga terdapat konten-konten seperti sanad dan matan. Di antara aplikasi hadis yang turut mewarnai di era digital adalah: Maktabah Syamilah, Lidwa Pusaka, Gawamil Kaleem, Mausyu’ah dan sebagainnya.Melihat perkembangan hadits sendiri yang sekarang sudah ber-Era digital maka sudah semestinya kita harus mengetahui bagaimana cara memanfaatkan hal itu, terlebih para akademi-akademisi tersebut sudah begitu bersemangat mengembangkan kajian hadits di era digital ini. Peran kita sebagai regenerasi hanyalah memaksimal mungkin dan mengembangkannya guna mengembangkan hirroh kajian hadits menuju era ke-emasan kembali.
Menggagas Dunia Digital di Pedesaan: Evaluasi Efektivitas Pendampingan Sistem Informasi di Gampong Balee Kecamatan Meureubo Aceh Barat
Authors: Zia Farhan Afra  , Lukman Ibrahim  , Wahyuni Sutari Hsb  , Andini Silfia , Rizkia Eva
Published: January 2024

Dalam era globalisasi dan kemajuan teknologi informasi, peran teknologi digital menjadi krusial dalam membentuk gaya hidup dan perkembangan masyarakat. Penelitian ini menyoroti pentingnya pendampingan sistem informasi desa dalam mendukung program pemerintah gampong khusunya Gampong Balee, Kecamatan Meureubo, Kabupaten Aceh Barat. Meskipun perkembangan teknologi digital dapat diimplementasikan di berbagai lapisan masyarakat, desa-desa seperti Gampong Balee menghadapi tantangan khusus, termasuk keterbatasan infrastruktur dan literasi teknologi. Evaluasi efektivitas pendampingan sistem informasi Gampong Balee menunjukkan dampak positif dalam meningkatkan transparansi dan efisiensi penyusunan program gampong. Meskipun Geuchik dan Ketua PKK Gampong Balee mengakui manfaatnya, namun pandangan masyarakat terbagi yaitu dengan beberapa dari mereka menyambut baik transparansi sistem, sementara yang lain mengatakan bahwa ketersediaan data masih sangat kurang bahkan sebagian yang lain belum bisa mengaksesnya. Disimpulkan bahwa diperlukan perhatian dan upaya yang lebih intensif untuk meningkatkan pemahaman dan aksesibilitas sistem informasi desa agar manfaatnya dapat dinikmati secara merata oleh seluruh masyarakat Gampong Balee melalui pendampingan dari Pemerintah Daerah, lembaga-lembaga mitra Pemerintah dan perguruan tinggi. Evaluasi ini memberikan dasar untuk perbaikan dan peningkatan penerapan teknologi informasi desa guna mendukung pembangunan yang lebih efektif dan inklusif.
Muamalah dalam Islam: Memahami Konsep 'Ariyah dan Aplikasinya
Authors: Suarni Suarni
Published: January 2024

The concept of 'Ariyah in Islam, within the framework of Muamalah (human interaction), holds a significant place in the social and economic aspects of Muslim life. This paper aims to explore the etymological and terminological dimensions of 'Ariyah and its practical implications in Islamic law. Employing a qualitative approach, this study draws on religious texts, including the Qur'an and Hadith, as well as scholarly works on Islamic jurisprudence. The analysis reveals that 'Ariyah, etymologically, is associated with the idea of borrowing and returning, and terminologically refers to the practice of utilizing another's possessions without compensation. This concept encompasses values of generosity and unconditional giving, with slight variations across Islamic schools of thought. The validity of 'Ariyah transactions in Islamic law depends on certain pillars and conditions, such as the declaration of borrowing, the ownership status of the lender and borrower, and the nature of the borrowed item. The concept of 'Ariyah aligns with the broader Islamic ethos of assistance and reciprocal cooperation, particularly in the practice of lending.

Abstrak

Konsep 'Ariyah dalam Islam, dalam kerangka Muamalah (interaksi manusia), memiliki tempat yang signifikan dalam aspek sosial dan ekonomi kehidupan Muslim. Tulisan ini bertujuan untuk mengeksplorasi dimensi etimologi dan terminologi dari 'Ariyah dan implikasi praktisnya dalam hukum Islam. Menggunakan pendekatan kualitatif, studi ini mengacu pada teks-teks agama, termasuk Al-Qur'an dan Hadits, serta karya-karya ilmiah tentang jurisprudensi Islam. Analisis mengungkapkan bahwa 'Ariyah, secara etimologi terkait dengan ide peminjaman dan pengembalian, dan secara terminologi merujuk pada praktik memanfaatkan kepemilikan orang lain tanpa kompensasi. Konsep ini mencakup nilai-nilai kemurahan hati dan pemberian tanpa syarat, dengan sedikit variasi lintas mazhab Islam. Keabsahan transaksi 'Ariyah dalam hukum Islam bergantung pada rukun dan syarat tertentu, seperti deklarasi peminjaman, status kepemilikan pemberi pinjaman dan penerima pinjaman, serta sifat barang yang dipinjam. Konsep 'Ariyah ini sejalan dengan etos Islam yang lebih luas tentang bantuan dan kerja sama timbal balik, terutama dalam praktik peminjaman.
Relasi Manusia dan Lingkungan Hidup dalam Islam
Authors: Djuned Muslim
Published: January 2024

The environmental issue has become a global concern, predominantly due to environmental damage caused by human activities. This study aims to explore the concept of the environment in Islam and human responsibility as  'khalifah' (stewards) in maintaining ecological balance and sustainability. The article employs a qualitative method, focusing on literature studies involving Islamic sacred texts and secondary literature related to ecology, environmental law, and ethics in Islam. The study demonstrates that Islam teaches a mutualistic relationship between humans and the environment. Humans, as khalifah, bear significant responsibility in environmental management. Environmental protection is governed in Islamic teachings, encompassing environmental ethics, the concepts of taskhir (subjugation) and khalifah, as well as penalties for environmental offenders. The article emphasizes that environmental conservation is a collective responsibility that must be shouldered by all humans. A holistic approach grounded in Islamic values, integrating law, ethics, and environmental awareness, is essential to address current and future environmental issues.

Abstrak

Isu lingkungan hidup telah menjadi perhatian global, dengan kerusakan lingkungan yang dominan akibat aktivitas manusia. Studi ini bertujuan untuk mengeksplorasi konsep lingkungan hidup dalam Islam dan tanggung jawab manusia sebagai 'khalifah' dalam menjaga keseimbangan dan kelestarian lingkungan. Artikel ini menggunakan metode kualitatif, berfokus pada studi literatur yang melibatkan teks-teks sakral Islam dan literatur sekunder terkait ekologi, hukum lingkungan, dan etika dalam Islam. Kajian ini menunjukkan bahwa Islam mengajarkan hubungan mutualistik antara manusia dan lingkungan. Manusia, sebagai khalifah, memiliki tanggung jawab besar dalam pengelolaan lingkungan. Perlindungan lingkungan diatur dalam ajaran Islam, yang mencakup etika lingkungan, konsep taskhir dan khalifah, serta hukuman bagi pelaku kerusakan lingkungan. Artikel ini menekankan bahwa pelestarian lingkungan hidup adalah tanggung jawab bersama yang harus diemban oleh semua manusia. Pendekatan holistik yang berlandaskan pada nilai-nilai Islam serta mengitegrasikan hukum, etika, dan kesadaran lingkungan diperlukan untuk mengatasi masalah lingkungan saat ini dan masa depan.
Smart City as an Element of Sustainable Development of the Metropolis
Authors: Aleksandrova O. A. , Minina M. V.
Published: January 2024

Nowadays, digitalization covers all spheres of life, including the housing and communal services sector. Smart technologies have been introduced in megacities such as St. Petersburg and Singapore for a long time, which make it possible to optimize the management of urban infrastructure and improve the quality of life of residents.

The object of the study is the digitalization of the sphere of housing and communal services in megacities.

The purpose of the article is to study the experience of the introduction of “smart” technologies in the housing and utilities sector in St. Petersburg and Singapore.

The article reveals the issues of digitalization of the sphere of housing and communal services.

The unique solutions of St. Petersburg and Singapore in the framework of the introduction of “smart” technologies in the field of housing and communal services are considered. Based on a comparative analysis of the experience of the introduction of “smart” technologies in the field of housing and communal services in two megacities, the main advantages and disadvantages are identified, and recommendations are formulated to St. Petersburg to improve this area based on the experience of Singapore.
Political and Educational Work in the Rear Support Units on the Kursk Bulge
Authors: Gridnev V. P.
Published: January 2024

The relevance of the publication is caused, firstly, by the 80th anniversary of the victory of the multinational Soviet people and its Armed Forces in the Battle of Kursk; secondly, by the increasing role and importance of military-patriotic education of the younger generation, which is a   barometer of Russian society. Based on archival materials of the Russian Center for the Storage and Study of Documents of Modern History, the Central Archive of the Ministry of Defence of the Russian Federation, the Institute of Russian History, the Military Medical Museum and other archives, materials of front-line and army newspapers, military memoirs of military commanders of the Red Army, such as Marshals of the Soviet Union G. K.   Zhukov, A.  M.  Vasilevsky, I.  S.   Konev the ideological and political work in the units and formations of the rear support of the troops in the battle of Kursk, the courage and heroism of the rear soldiers who provided the troops with all types of weapons and military equipment, ammunition and fuel, food and equipment are considered.
Impact of the Urban Regime on the Urban Spatial Transformation of Saint Petersburg in the 21st Century (On the Example of Ecological and Eco-Cultural Conflicts)
Authors: Galustov K. A.
Published: January 2024

Aim: Identification of the features of the impact of the urban regime dynamics on the transformation of the urban space of Saint Petersburg in the 21st century.

Methods: Quantitative and qualitative methods of sociological research (expert survey, media content analysis, case analysis); math modeling (conversion of the conflict base into quantitative indicators, calculation of the scoring system and spatio-temporal models of the impact of the urban regime dynamics on the urban spatial transformation); mapping; typology.

Results & discussion:  Empirical material was obtained on the basis of spatio-temporal models. It demonstrates the features of urban changes in the context of the urban regime dynamics in Saint Petersburg. The urban regime transformation goes from the growth to the progressive regime of the middle class, there was identified new transitional urban regime of situational (tactical) coordination. Urban regime and its impact in different city parts were investigated on the basis of maps.

Conclusions: Ecological and eco-cultural conflicts are relevant indicators of the urban regime dynamics and changes of the urban space. Such features are identified as the expansion of conflict zones of interaction between actors from the center of St. Petersburg to the eastern semi-periphery and periphery. At the same time, the studied processes have a   complex, mosaic spatial structure.