bluuebunny/crossref_metadata_2025 huggingface dataset:
International practice of the activity approach in higher pedagogical education
Authors: Alisov Evgenii A.
Published: December 2022

We present the results of a comparative pedagogical study, the purpose of which was to identify and characterize the directions of application of the activity approach (as a key methodological basis) implemented in the world educational practice to the organization of the system of lecturer training. The study was conducted using classical methods for comparative pedagogy: comparative, descriptive, inductive-deductive. The considered in the study trends determine the general patterns of designing educational programs for lecturer training in many countries of the world with high quality education. A detailed description of the essential content of the epistemic spaces of the activity approach is given: paradigms, syntagmas and pragmatics, taking into account the specifics of the university training of teachers in Russia, the USA, the Netherlands, Norway, Sweden, Cyprus, Thailand, Malaysia and other countries. As the key guidelines of modern higher pedagogical education from the perspective of the activity approach the following are designated: a target orientation for continuous professional self-improvement, meaning-forming preparation for solving life tasks, personalization of the educational environment of the university, organization of joint network activities. The application of the activity approach correlates with the educational results, which are normatively fixed in the standards. The principles of the system-modular organization of higher pedagogical education are updated. We consider the specific features of the implementation of the conceptual foundations of the activity approach in higher pedagogical education at the present stage of the development of world educational systems. Based on the generalization and systematization of a number of theoretical and empirical scientific and pedagogical studies, it is concluded that it is necessary to preserve the activity basis in the practice of implementing educational programs of higher pedagogical education, with the introduction of innovations that meet the general trends in the functioning of educational systems around the world.
Desempenho higrotérmico de paredes de alvenaria em edificação residencial em clima subtropical úmido
Authors: Buligon Liliane Bonadiman , Macarthy Maritza da Rocha , Bernardes Luiza Coutinho , Leitzke Rodrigo Karini , Grigoletti Giane de Campos , Cunha Eduardo Grala da
Published: December 2022

A falta do controle da umidade em edificações pode afetar a durabilidade dos materiais, o conforto térmico, o consumo energético e a qualidade do ar interno, assim como propiciar o crescimento de micro-organismos (fungos filamentosos) prejudiciais à saúde do usuário. Nesse contexto, o objetivo deste estudo é analisar o comportamento higrotérmico de quatro configurações de sistemas de vedação vertical externa (SVVE) de tijolos cerâmicos com diferentes níveis do isolamento térmico e estanqueidade à água para o clima subtropical úmido. Para isso, foram definidas as tipologias SVVE; em seguida, foram realizadas as simulações da edificação, considerando duas condições: ventilada naturalmente e condicionada artificialmente. Foram utilizados dois programas de simulação computacional: EnergyPlus (versão 8.7) e WUFI Pro 6.5. E por fim, foram avaliados os resultados quanto ao teor de umidade total, risco de condensação e o risco de formação de fungos filamentosos. Os resultados mostram que nas paredes que atendem aos requisitos da NBR 15575 não houve garantia da minimização da umidade na superfície interna, nem mesmo para os ambientes com climatização artificial. Quanto à formação de fungos filamentosos, só foi possível evitar os problemas nos ambientes com temperatura controlada, exceto na parede de tijolo cerâmico que apresentou risco em todas as condições simuladas.
Cartográfias afetivas
Authors: Kasper Kátia Maria , Tóffoli Gabriela de Sousa , Sejanes Thalita Alves
Published: December 2022

Este ensaio escreve-se pela cidade, pelas marcas de quem por ela caminha.  A cidade se provoca no texto: contra-diz. Cidade fértil: brota, respira, transpira. A cidade escuta a si mesma, irrompe, risca. O caminhante intervém nela produzindo paisagens, arquiteturas, meios-lugares, quedas, derivas, (in)servíveis. A cidade emaranha suas direções com encontros (im)possíveis. Com existências mínimas (LAPOUJADE, 2017), enquanto caminhar se delineia com uma prática filosófica (GROS, 2010). O caminhante, errante, vagabundo: texto em equilíbrio precário, entre os fios de uma rede (DELIGNY, 2015). Fio a fio, o caminhar e a cidade cartografam-se (ROLNIK, 2007; DELIGNY, 2015) neste texto, mapeando os trajetos vagos e os desenhos da caminhada.
Testemunho e memoriável
Authors: Rodrigues Andréa , Branco Luiza Castello
Published: December 2022

Esta resenha objetiva apresentar o livro Testemunhos de resistência e revolta – um estudo em Análise do Discurso, escrito por Bethania Mariani. A coletânea de textos traz o testemunho como objeto discursivo, a-bordando nesse gesto noções de sujeito, inconsciente, ideologia, real – questões que insistem em seu percurso teórico-metodológico na Análise de Discurso, atravessada pela Psicanálise. Dessa forma, Mariani tece seu emaranhado de fios pelo modo como seu objeto de estudo funciona em cada textualidade analisada. Ao longo dos oito capítulos, o livro traça um percurso de leituras discursivas do testemunho em diferentes objetos de análise. E o leitor pode acompanhar essa trajetória para seguir refletindo então sobre a noção de testemunho, seus modos de funcionamento, suas relações com o indizível, com o real da história e da língua, com a urgência de certos dizeres, com a resistência e a revolta, entre muitas outras questões que vão surgindo a cada página virada.
Do mais recente ao mais antigo – In Memoriam Francisco Laranjo
Authors: Lambert Maria de Fátima
Published: December 2022

Este artigo se relaciona com a poética do pintor Francisco Laranjo artista que cumpre uma exigência de rigor e depuração da própria linguagem pictural organizando as duas componentes direccionais da sua fundamentação estética: o caminho de dentro e os caminhos do exterior., através de uma resolução aguda e profundamente adequada ao seu desígnio estético e às condições de práxis artística. Regulariza a convergência opcional da sua via enquanto responde ao encaminhamento volcado para a sabedoria.
Syafaqul Ahmar dan Syafaqul Abyadh
Authors: Almutadi Ahmad Saifulhaq
Published: December 2022

Penelitiannya ini bertujuan untuk mengkaji pengaruh syafaq matahari terhadap awal waktu Maghrib dan Isya. Metode yang digunakan dalam penelitian ini yaitu metode kualitatif. Sedangkan teknik pengumpulan datanya dilakukan melalui studi pustaka berbagai catatan, buku-buku ilmiah serta jurnal-jurnal ilmiah yang terkait tema studi yang dilakukan. Hasil studi menunjukkan bahwa Syafaq ahmar merupakan tanda berakhirnya waktu Maghrib dan awal waktu Isya?. Adapun syafaq abyadh sebagaimana yang dipedomani oleh madzhab Hanafi dan Hambali digunakan pada saat normal, pada waktu-waktu tertentu, madzhab tersebut juga menggunakan syafaqul ahmar sebagai penentu awal Isya?. Selain itu, diketahui juga bahwa hilangnya syafaq sebagai fenomena penentuan awal waktu Maghrib dan Isya? dipengaruhi oleh lintang dan musim yang bervariasi di tempat satu dan lainnya.
Studi Analisis Akurasi Perhitungan Awal Waktu Shalat Menggunakan Universal Astrolabe
Authors: Hadi Imron
Published: December 2022

Universal Astrolabe is a type of Astrolabe that can be used in any region or latitude. This paper examines the accuracy of the Universal Astrolabe in determining the start of the five daily prayer times (Fajr, Zuhur, Asr, Maghrib and Isha). The purpose of this study was to determine the accuracy of the calculation method for determining the beginning of prayer times using the Universal Astrolabe. Astrolabe is one of the classical astronomical instruments that describes the celestial sphere in two dimensions and was originally used to determine the position of the Sun. Astrolabe comes from the Greek language which consists of the word "aster" which means star, and the word "labio" which means take, understand, and catch. In simple terms, Astrolabe can be interpreted as a tool to study the Stars. This instrument is a type of calculating tool. The function of the Astrolabe is very complex, namely to determine the position of the Sun or other stars, to determine the zodiac and its circulation scale, to determine the height of an object and determine solar time. The results showed that the method of calculating the initial prayer time applied in the Universal Astrolabe was the method of reading directly on the plate. The initial calculation of prayer times using the Universal Astrolabe results in a calculation difference between 0-3 minutes and the prayer time schedule set by the Ministry of Religion of the Republic of Indonesia, so it is considered quite accurate. This difference can be influenced by the diameter of the Universal Astrolabe and the accuracy of the reader when reading the curves and numbers listed on the Universal Astrolabe.Keywords: Prayer Times, Accuracy, Universal Astrolabe.
HIPÓTESES DE SOLIDARIEDADE CRIADAS PELA JURISPRUDÊNCIA: RESPONSABILIDADE CIVIL PELA PROPRIEDADE DA COISA E PRESUNÇÃO DE SOLIDARIEDADE À LUZ DO CÓDIGO CIVIL DE 2002
Authors: Lung Frigi Larissa , Cação Vinhas Tiago , Conte André Victor
Published: December 2022

Este artigo tem por objetivo analisar, com base na lei e na doutrina civilista, em que medida as hipóteses de solidariedade passiva que incidem no âmbito da responsabilidade civil derivada da propriedade da coisa são compatíveis com os pressupostos da responsabilidade civil recepcionados pelo Código Civil de 2002. Para tanto, fez-se necessária a análise de aspectos técnicos da solidariedade obrigacional e do contexto fático e normativo em que se insere a responsabilidade civil pela guarda da coisa. O modo indiscriminado pelo qual a jurisprudência vem presumindo a responsabilidade solidária do proprietário e a trivial utilização da dignidade da pessoa humana como fundamento para tanto exprimem desprezo à hermenêutica e ausência de apego às escolhas legislativas. Mais que isso, violam a própria legalidade constitucional, que jamais corroboraria para a sujeição agravada de um patrimônio senão pelos estritos termos da lei.
CONTINGÊNCIA ONTOLÓGICA DO DIREITO E MEDIAÇÃO
Authors: Saliba Moreira Pinto Samuel
Published: December 2022

Resumo: O presente artigo objetiva avaliar potenciais contribuições da mediação para a pacificação social, frente ao “problema” da indeterminação ontológica do Direito e o ativismo judicial. Adota-se metodologia teórica e bibliográfica, com abordagem dedutiva e procedimento comparativo, a fim de revisar a literatura relacionada com a indeterminação do Direito, com o ativismo judicial no Brasil e com os métodos autocompositivos de solução de conflitos. Dadas as dificuldades teóricas de estabelecimento de critérios de obtenção de verdade em Direito, notadamente nas demandas judiciais, no que toca as decisões, possível que a mediação, como forma autocompositiva de solução de conflitos, contribua para a pacificação social de forma (mais) eficiente.
Validation of the Use of Bloom's Revised Taxonomy as a Tool for the Design of Assessment Tests
Authors: Pizà-Mir Bartolomé
Published: December 2022

(1) Background: This study aims to validate the use of Bloom's revised taxonomy as an instrument for the design of assessment tests; (2) Methods: A validation has been carried out by external judges, as well as by teachers and students, validating the instrument by means of Aiken's V; (3) Results: Judges, teachers and students consider Bloom's revised taxonomy as an effective tool for the design of assessment tests; (4) Conclusions: Using Bloom's revised taxonomy as a model for designing assessment tests promotes learning.
Urban Resilience to Climate Change between the Strategic and Regulative Dimensions of Urban Planning. An Overview of the Italian Context
Authors: Mariano Carmela
Published: December 2022

The paper provides a critical synthesis of analysis and evaluation of some case studies in the Italian national context, which allowed, through an inductive method, to assess, in terms of integration and coherence, the process of transposition of climate change adaptation contents, possibly already contained within a regional urban framework (Regional Urban Laws) or specific Regional Adaptation Strategies or Local Adaptation Plans, within the territorial and urban planning tools of metropolitan or local scale.
Potential Role of Carbon Nanomaterials in the Treatment of Malignant Brain Gliomas
Authors: Caffo Maria , Curcio Antonello , Caruso Gerardo , Rajiv Kumar , Germanò Antonino
Published: December 2022

Malignant gliomas are the most common primary brain tumors in adults up to an extent of 78% of all primary malignant brain tumors. However, total surgical resection is almost unachievable due to considerable infiltrative ability of glial cells. The efficacy of current multimodal therapeutic strategies is, furthermore, limited by the lack of specific therapies against malignant cells, and, therefore, the prognosis these in patients is still very unfavorable. The limitation of conventional therapies, which may result from inefficient delivery of the therapeutic or contrast agent to brain tumors are major reasons for this unsolved clinical problem. The major problem in brain drug delivery is the presence of the blood brain barrier which limits the delivery of many chemotherapeutic agents. Nanoparticles, thanks to their chemical configuration, are able to go through the blood-brain barrier carrying drugs or genes targeted against gliomas. Carbon nanomaterials show distinct properties including electronic properties, penetrating capability on the cell membrane, high drug-loading and pH-dependent therapeutic unloading capacities, thermal properties, large surface area and easy modification with molecules, which render them as a suitable candidate to deliver drugs. In this review we will focus on the potential effectiveness of the use of carbon nanomaterials in the treatment of malignant gliomas discussing the current progress of in vitro and in vivo researches of carbon nanomaterials-based drug delivery to brain.
Klotho Regulated by Estrogen Plays a Key Role in Sex Differences in Stress Resilience
Authors: Tan Zhinei , Li Yongxia , Guan Yinzheng , Iqbal Javed , Wang Chenyue , Ma Xinming
Published: December 2022

Klotho (KL) is a glycosyl hydrolase and aging-suppressor gene. Stress is a risk factor for depression and anxiety that are highly comorbid with each other. The aim of this study was to determine KL is regulated by estrogen and plays an important role in sex differences in stress resilience. Our results showed that KL was regulated by estrogen in rat hippocampal neurons in vivo and in vitro and was essential for estrogen-mediated increase in the number of presynaptic vesicular glutamate transporter 1 (Vglut1) positive clusters on the dendrites of hippocampal neurons. The role of KL in sex differences in stress responses was examined in rats using three-week chronic unpredictable mild stress (CUMS). CUMS produced a deficit in spatial learning and memory, anhedonic-like and anxiety-like behaviors in male but not female rats, which was accompanied by a reduction in KL protein levels in the hippocampus of male, but not female rats. This demonstrated the resilience of female rats to CUMS. Interestingly, knockdown of KL protein levels in the rat hippocampus of both sexes caused a decrease in stress resilience in both sexes, especially in female rats. These results suggest that regulation of KL by estrogen plays an important role in estrogen-mediated synapse formation, and KL plays a critical role in the sex differences in cognitive deficit, anhedonic-like and anxiety-like behaviors induced by chronic stress in rats, highlighting an important role of KL in sex differences in stress resilience.
Microchimerism, PERV and xenotransplantation
Authors: Denner Joachim
Published: December 2022

Microchimerism is the presence of cells in an individual that have originated from another individual. The most common form of microchimerism is fetomaternal microchimerism, i.e., cells from a fetus pass through the placenta and establish cell lineages within the mother. Microchimerism was also described after transplantation of human organs in human recipients. Consequently, microchimerism may also be expected in xenotransplantation using pig cells or organs. Indeed, microchimerism was described in patients after xenotransplantations as well as in non-human primates after transplantation of pig organs. Here for the first time a comprehensive review of microchimerism in xenotransplantation is given. Since pig cells contain porcine endogenous retroviruses (PERVs) in their genome, detection of proviral DNA in the transplant recipients may be misinterpreted as infection of the recipient with PERV. To prevent this, methods discriminating between infection and microchimerism are described. This knowledge will be important for the interpretation of screening results in forthcoming human xenotransplantations.
SARS-CoV-2 Breakthrough Infections after Third Doses Boost IgG Specific Salivary and Blood Antibodies
Authors: Badano Maria Noel , Pereson Matias , Sabbione Florencia , Keitelman Irene , Aloisi Natalia , Chuit Roberto , Elizalde de Bracco Maria Marta , Fink Susana , Bare Patricia
Published: December 2022

SARS-CoV-2 breakthrough infections, associated with waning immunity, increase systemic antibody levels. In this study, we analyzed the impact of the infection timing on the magnitude of the systemic humoral response and whether breakthrough infections also boost antibody levels in the salivary compartment. We observed that the combination of infection plus vaccination, regardless of infection timing, produced a sharp increase of systemic antibodies, being higher in subjects infected after third doses. Moreover, despite high systemic antibody levels, breakthrough infections after dose 3 occurred and boosted antibody levels in the salivary compartment. These results lead to rethink the current vaccination strategies against COVID-19 and the use of salivary anti-SARS-CoV-2 antibodies for disease surveillance and vaccination follow-up.
Two-Steps Identification of N-, S-, R- and T-cytoplasm Types in Onion Breeding Lines using High Resolution Melting (HRM)-Based Markers
Authors: Khrustaleva Ludmila , Nzeha Mais , Ermolaev Aleksey , Nikitina Ekaterina , Romanov Valery
Published: December 2022

High resolution melting (HRM) analysis is a powerful detection method for fast, high-throughput post-PCR analysis. A two-step HRM marker system was developed for identification of the N-, S-, R- and T-cytoplasms of onion. In the first step for identification of N-, S-, and R-cytoplasms, one forward primer was designed to the identical sequences of both cox1 and orf725 genes and two reverse primers specific to the polymorphic sequences of cox1 and orf725 genes were used. For the second step breeding lines with N-cytoplasm were evaluated with primers developed from the orfA501 sequence to distinguish between N- and T-cytoplasms. An amplicon with primers to the mitocondrial atp9 gene was used as an internal control. The two-step HRM marker system was tested using 246 onion plants. HRM analysis showed that the most common source of CMS, often used by Russian breeders, is S-cytoplasm, the rarest type of CMS is R-cytoplasm, and the proportion of T-cytoplasm among the analyzed breeding lines was 20.5%.
Looking Deeper into Images for Autonomous Road Weather Detection
Authors: Samo Madiha , MAFENI MASE JIMIAMA MOSIMA , Figueredo Grazziela
Published: December 2022

There is great interest in automatically detecting road weather and understanding its impacts on the overall safety of the transport network. This can, for example, support road condition-based maintenance or even serve as detection systems that assist safe driving during adverse climate conditions. In computer vision, previous work has demonstrated the effectiveness of deep learning in predicting weather conditions from outdoor images. However, training deep learning models to accurately predict weather conditions using real-world road-facing images is difficult due to: (1) the simultaneous occurrence of multiple weather conditions; (2) imbalanced occurrence of weather conditions throughout the year; and (3) road idiosyncrasies, such as road layouts, illumination, road objects etc. In this paper, we explore the use of focal loss function to force the learning process to focus on weather instances that are hard to learn with the objective to help address data imbalance. In addition, we explore the attention mechanism for pixel based dynamic weight adjustment to handle road idiosyncrasies using state-of-the-art vision transformer models. Experiments with a novel multi-label road weather dataset show that focal loss significantly increases the accuracy of computer vision approaches for imbalanced weather conditions. Furthermore, vision transformers outperforms current state-of-the-art convolutional neural networks in predicting weather conditions with a validation accuracy of 92% and F1-score of 81.22%, which is impressive considering the imbalanced nature of the dataset.
Autoantibody Correlation Signatures in Fibromyalgia and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Association with Symptom Severity
Authors: Ryabkova Varvara A , Gavrilova Natalia Y , Poletaeva Alina A , Pukhalenko Aleksandr I , Koshkina Irina A , Churilov Leonid P , Shoenfeld Yehuda
Published: December 2022

(1) Background: Recent studies provide some evidence for the contribution of antibody-mediated autoimmune mechanisms to the nature of fibromyalgia (FM) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Much attention was paid to the autoantibodies (AAb) targeting G protein-coupled receptors as natural components of the immune system. However, natural AAb network is much more extensive, and has not been previously investigated in these disorders; (2) Methods: The enzyme immunoassays ELI-Viscero-Test and ELI-Neuro-Test were used to determine changes in serum content of a 33 natural AAb to neural, organ-specific and non-tissue-specific autoantigens a) in 11 FM patients with comorbid ME/CFS; b) in 11 ME/CFS patients without FM; c) in 11 healthy controls. Individual autoantibody profiles and their correlation with some clinical symptoms were analyzed. (3) Results: both patients with ME/CFS and ME/CFS+FM were characterized by more frequent and pronounced deviations in the immunoreactivity to GABA-receptors than healthy controls. Although the level of other natural AAb did not differ between study groups, AAb correlation signatures were changing in patients compared to healthy controls. Both in patients and healthy controls the level of natural AAb to various neural and tissue-specific antigens correlated with the severity of fatigue, bodily pain, depression, anxiety, physical and mental-health related quality of life. Notably, that widely different correlation patterns were observed between study groups. (4) Conclusions: Findings from this pilot study provide some evidence that the homeostasis of autoimmune relationships, which are possibly a physiological part of our immune system, may break down in FM and ME/CFS. The correlation of disease-induced perturbations in individual AAb profiles with some clinical symptoms may arise from the immune system's ability to reflect qualitative and quantitative changes in antigenic composition of the body.
Parameterization of Eddy Mass Transport in the Arctic Seas based on the Sensitivity Analysis of Large-scale Flows
Authors: Platov Gennady , Iakshina Dina , Golubeva Elena
Published: December 2022

The characteristics of the eddy mass transport are estimated depending on the values of the parameters of a large-scale flow that forms under the conditions of the shelf seas in the Arctic. For this, the results of numerical simulation of the Kara Sea with a horizontal resolution permitting the development of mesoscale eddies are used. The parameters resulting from numerical experiment are considered as a statistical sample and are analyzed using methods of sensitivity study and clustering of sample elements. Functional dependencies are obtained that are closest to the simulated distributions of quantities. These expressions make it possible, within the framework of large-scale models, to evaluate the characteristics of the cross-isobatic eddy mass transport in the diffusion approximation with a counter-gradient flux. Numerical experiments using the SibCIOM model showed that areas along the Fram branch of the Atlantic waters trajectory in the Arctic as well as the shelf of the East Siberian and Laptev seas with adjacent deep water areas are most sensitive to proposed parameterization of eddy exchanges. Accounting for counter-gradient eddy fluxes turned out to be less important.
Keragaman Genetik Kemiri [Aleurites moluccana (L.) Willd.] Berdasarkan Barkode DNA Maturase K (matK)
Authors: Madyasti Fajrin Suci , Tresniawati Cici , Annisa Annisa
Published: December 2022

Tanaman kemiri [(Aleurites moluccana (L.) Willd.] merupakan tanaman yang memiliki potensi tinggi dan bersifat multiguna dalam berbagai bidang seperti bahan masakan, bahan baku obat-obatan, dan bahan baku industri lainnya. Namun, produksi A. moluccana masih rendah sehingga memerlukan adanya perbaikan-perbaikan dalam praktek budidaya tanaman dan bahan tanam yang berasal dari varietas unggul baru. Informasi keragaman dan kekerabatan genetika diperlukan dalam upaya merakit varietas yang unggul. Penelitian ini bertujuan untuk mengetahui keragaman genetik A. moluccana menggunakan barkode DNA matK. Penelitian ini merupakan penelitian eksploratif dengan menggunakan metode observasi yang meliputi pengoleksian sampel, ekstraksi DNA dengan metode CTAB, kuantifikasi DNA, amplifikasi dengan barkode DNA matK, pengurutan (sekuensing), dan analisis data. Bahan tanaman yang digunakan adalah sebelas aksesi kemiri yang berasal dari Alor, Jatinangor, Majalengka, dan Sukabumi. Analisis keragaman dan kekerabatan dilakukan menggunakan MEGA 11. Hasil observasi menunjukkan gen matK berhasil diamplifikasi dan diurutkan dari seluruh sampel dengan panjang sekuen sekitar 622 bp. Analisis spesifitas sekuen menggunakan BLAST menunjukkan persen identitas sebesar 99,37%-99,68%. Analisis keragaman genetik menunjukkan keragaman nukleotida yang sangat rendah yaitu sebesar 0,00027 dengan jumlah situs polimorfik yaitu 2 dari 618 situs. Rekonstruksi pohon filogenetik dengan metode Neighbor-Joining menghasilkan satu clade tunggal dengan jarak genetik yang sangat rendah. Hal ini menunjukan DNA matK yang digunakan memiliki keragaman genetik yang sangat rendah serta tidak mampu mendiskriminasi aksesi A. moluccana yang terdapat dalam penelitian ini. 
Operating Thermal Power Plants Efficiency Improvement under Current Conditions
Authors: Yanchuk V. V. , Romaniuk V. N.
Published: December 2022

In the present-day conditions, the issue of energy saving is becoming increasingly acute and permanently relevant. This situation is caused by rapid growth in prices for primary energy resources and by the need to reduce the share of natural gas in the incoming part of the energy balance of Belarus. According to available statistics, with the commissioning of the Belarusian NPP, the share of natural gas in the incoming part of the energy balance decreases from 97 to 59 %. In the economic complex, the share of this primary energy resource is projected at 70 %. The problem of energy saving is solved most rationally and with the least investment only by increasing the efficiency of natural gas use, especially due to the commissioning of the Belarusian NPP, the issue of preserving the possibility of using centralized heating facilities is acute. It is necessary to increase the thermodynamic efficiency of the cycles of steam turbine plants, both heating and condensing, which form the basis of the generation of the Belarusian power system, in order to restore the energy characteristics of the power system, which have somewhat decreased with the commissioning of the NPP. In the limit, the share of natural gas in the incoming part of the energy balance should be reduced to values not exceeding 50 %, in accordance with the requirements of energy security. The article considers examples of utilization of low-temperature secondary energy flows occurring at thermal power plants: the heat of the cooling processes of the generator, lubrication systems, as well as the heat of condensation of turbine exhaust steam and deeper cooling of flue gases. On the basis of this review, it is expected to identify promising areas of relevant research in relation to the energy system of Belarus.
Features of Modeling the Operating Modes of Outdoor Lighting Lines
Authors: Kalechyts V. N.
Published: December 2022

The necessity of modeling the operating modes of outdoor lighting lines with a voltage of 0.23/0.4 kV is substantiated. The choice of the optimal configuration of the lighting line while ensuring the standardized values of illumination and brightness on the working surface is recommended to be carried out by comparing several variants with different positions of pillars, types of light intensity curves, the number and power of luminaires. The results of the lighting calculation are the basis for modeling the electrical operation modes of outdoor lighting lines, which allows determining the operating parameters (node voltage, active and reactive power, current, voltage drop, loss of active and reactive power in individual sections). The obtained data can be used to select the cross-sectional area of conductor cores and forecast the power consumption of outdoor lighting, taking into account the specific features of light flux regulation (dimming). As a rule, outdoor lighting lines are connected to one power point. The use of outdoor lighting lines with bilateral supply for main streets and circular roads of relatively long length is proposed which will not only make it possible to increase the reliability of power supply of lighting installations, but also to use conductors with a smaller cross-section area of the cores. The electrical load of light sources is assumed on the basis of static characteristics. Modeling of the electrical modes of the outdoor lighting network is carried out taking into account the higher harmonics of current and voltage. The rational operation mode of the outdoor lighting line is determined by the magnitude of the voltage deviation from the nominal value, the indicators of non-sinusoidality and voltage asymmetry at the power supply point. Additional possibilities for modeling the modes of operation of lighting lines are to search for damage (detection of short circuits, determination of the presence of faulty lamps).
Diseño de un prototipo de ladrillo a base de PET y Javara ichu para construcciones termoaislantes en asentamientos humanos de Lima
Authors:   , Navarrete Huachallanqui John Walter , Condori Santivañez Danyely Anyery
Published: December 2022

En la presente tesis se evaluó la propiedad física (peso) y mecánica (resistencia a la compresión) de los ladrillos a base de tereftalato polietileno (PET) e ichu mezclados con cemento y arena fina. Las muestras fueron en proporción de 35% PET - 60% arena - 5% ichu, 40% PET - 60% arena, 45% PET - 50% arena - 5% ichu, 50% PET - 50% arena, 55% PET - 40% arena - 5% ichu y 60% PET - 40% arena. Los resultados mostraron que la resistencia a la comprensión de la muestra PET 35% tuvo una diferencia significativa con las demás muestras y en comparación con la norma técnica peruana se asemejó al ladrillo de concreto tipo 17. Se elaboraron 575 ladrillos de la muestra PET 35% que sirvieron para construir el prototipo de vivienda donde se evaluaron las temperaturas internas y humedad relativa durante cinco días consecutivos y se compararon con los resultados obtenidos en habitaciones comunes del asentamiento humano: dormitorio 1 (HC1), cocina (HC2), dormitorio 2 (HC3), sala de estudio (HC4) y comedor (HC5). El promedio de las temperaturas en el prototipo fue mayor a 2 °C en comparación con las habitaciones comunes. El porcentaje de humedad en HC3 y HC4 tuvo diferencia significativa con los valores obtenidos en el prototipo construido, por el contrario, no hubo diferencia significativa con HC1, HC2 y HC5, pero se mantuvo por debajo de los valores. El ladrillo de concreto a base de PET e ichu permiten mantener la temperatura interna por un periodo prolongado, estos ladrillos pueden usarse como una solución alternativa en trabajos de albañilería sin someterse a grandes cargas o funciones estructurales.
Dexmedetomidine regulates autophagy via the AMPK/mTOR pathway to improve SH-SY5Y-APP cell damage induced by high glucose
Authors: Chen Pinzhong , Chen Xiaohui , Zhang Honghong , Chen Jianghu , Lin Mingxue , Qian Haitao , Gao Fei , Chen Yisheng , Gong Cansheng , Zheng Xiaochun , Zheng Ting
Published: December 2022

Neurodegenerative diseases and postoperative cognitive dysfunction (POCD) involve the accumulation of β-amyloid peptide (Aβ). High glucose can inhibit autophagy, which facilitates intracellular Aβ clearance. The α2-adrenoreceptor agonist dexmedetomidine (DEX) can provide neuroprotection against several neurological diseases; however, the mechanism remains unclear. This study investigated whether DEX regulated autophagy via the AMPK/mTOR pathway to improve high glucose-induced neurotoxicity in SH-SY5Y/APP695 cells. SH-SY5Y/APP695 cells were cultured with high glucose with/without DEX. To examine the role of autophagy, the autophagy activator rapamycin (RAPA) and the autophagy inhibitor 3-methyladenine (3-MA) were used. The selective AMPK inhibitor compound C was used to investigate the involvement of the AMPK pathway. Cell viability and apoptosis were examined by CCK-8 and annexin V-FITC/PI flow cytometric assays, respectively. Autophagy was analyzed by monodansylcadaverine (MDC) staining of autophagic vacuoles. Autophagy- and apoptosis-related protein expression and the phosphorylation levels of AMPK/mTOR pathway molecules were quantified by western blotting. DEX pretreatment significantly suppressed high glucose-induced neurotoxicity in SH-SY5Y/APP695 cells, as evidenced by the enhanced viability, restoration of cellular morphology, and reduction in apoptotic cells. Furthermore, RAPA had a protective effect similar to that of DEX, but 3-MA eliminated the protective effect of DEX by promoting mTOR activation. Moreover, the AMPK/mTOR pathway involved DEX-mediated autophagy. Compound C significantly suppressed autophagy and reversed the protective effect of DEX against high glucose in SH-SY5Y/APP695 cells. Our findings demonstrated that DEX protected SH-SY5Y/APP695 cells against high glucose-induced neurotoxicity by upregulating autophagy through the AMPK/mTOR pathway, suggesting a role of DEX in treating POCD in diabetic patients.
Methods of postoperative void trial management after urogynecologic surgery ： a systematic review and meta-analysis
Authors: Dong Xue , Huang Wu , Niu Jinyang , Lei Tingting , Tan Xin , Guo Tao
Published: December 2022

Background: To systematically review and meta-analyze postoperative void trials (VTs) following urogynecologic surgery to investigate (1) the optimal postoperative VT methodology and (2) the optimal criteria for assessing VT.
Method: We searched the PubMed, EMBASE, Cochrane Library, Ovid Medline, and relevant reference lists of eligible articles up to April 2022. This review included randomized controlled trials (RCTs). Relative risks (RRs) and weighted mean differences (WMDs), each with 95% confidence intervals (CIs) were also calculated. The risk of bias was assessed using the Cochrane Risk of Bias tool.
Results: VT methodology included backfill-assisted and autofill studies (two RCTs, n=95). Backfill assistance was more likely to be successful than autofill (RR 2.12, 95% CI 1.29, 3.47, P = .00); however, no significant difference was found in the time to discharge (WMDs= –29.11 min, 95% CI -57.45, 1.23, P = .06). Criteria for passing VT included subjective assessment of the urinary force of stream (FOS) and objective assessment of the standard voiding trial (SVT) (3 RCTs, n=377). No significant differences were found in the correct passing rate (RR 0.97, 95% CI 0.93, 1.01, P = .14) or VT failure rate (RR 0.78, 95% CI 0.52,1.18, P = .24). Moreover, no significant differences were found in the complication rates orpatient satisfaction between the two criteria.
Conclusion: Bladder backfilling was associated with a lower rate of catheter discharge after urogynecologic surgery. The subjective assessment of FOS is a reliable and safe method for assessing postoperative voiding because it is less invasive.
Systematic review registration: PROSPERO CRD42022313397.
polyBERT: A chemical language model to enable fully machine-driven ultrafast polymer informatics
Authors: Kuenneth Christopher , Ramprasad Rampi
Published: December 2022

Polymers are a vital part of everyday life. Their chemical universe is so large that it presents unprecedented opportunities as well as significant challenges to identify suitable application-specific candidates. We present a complete end-to-end machine-driven polymer informatics pipeline that can search this space for suitable candidates at unprecedented speed and accuracy. This pipeline includes a polymer chemical fingerprinting capability called polyBERT (inspired by Natural Language Processing concepts), and a multitask learning approach that maps the polyBERT fingerprints to a host of properties. polyBERT is a chemical linguist that treats the chemical structure of polymers as a chemical language. The present approach outstrips the best presently available concepts for polymer property prediction based on handcrafted fingerprint schemes in speed by two orders of magnitude while preserving accuracy, thus making it a strong candidate for deployment in scalable architectures including cloud infrastructures.
Aqueous Humor Cytokine Profiles of Pachychoroid Spectrum Diseases
Authors: Mao Jianbo , Chen Nuo , Zhang Caiyun , Zhang Shian , Xiang Ziyi , Shen Lijun
Published: December 2022

Objectives
To investigate cytokine profiles in the aqueous humor (AH) of patients with central serous chorioretinopathy (CSC), pachychoroid neovasculopathy (PNV), and polypoidal choroidal vasculopathy (PCV).
Methods
The prospective study included a total of 172 eyes. AH samples were collected from 65 eyes with CSC, 24 with PNV, and 43 with PCV before intravitreal anti-vascular endothelial growth factor (VEGF) injection and cataract surgery in 40 control eyes. Multiplex bead assay was used for analysis of cytokines, including VEGF, interleukin-6 (IL-6), IL-8, IL-10, interferon-inducible protein 10 (IP-10), macrophage chemoattractant protein 1 (MCP-1). Differences in cytokine levels between groups were assessed.
Results
No differences were noted in IL-6 (P = 0.122) and MCP-1 (P = 0.054) levels among the CSC, PNV, PCV, and controls. VEGF levels in CSC, PNV, and PCV were significantly higher than in controls (all P < 0.05). In CSC or PNV, no other inflammatory cytokines were upregulated except for VEGF compared to controls. In PCV, VEGF, IL-10, and IP-10 levels were significantly higher than those in controls. In addition, we compared the cytokines levels between two pigment epithelial detachment (PED) types in CSC patients. VEGF levels were significantly higher in eyes with flat irregular PED (FIPED) than in focal PED (P = 0.027).
Conclusions
In CSC and PNV, VEGF levels were elevated without the elevation of other inflammatory cytokines, indicating that inflammation was not the dominant factor on CSC and PNV diseases. PCV had significantly distinct cytokine profiles in the AH compared with controls. Elevated angiogenic and inflammatory cytokines, including VEGF, IL-10, and IP-10, may contribute to the pathogenesis of PCV. In addition, higher VEGF levels in CSC patients with FIPED verified that VEGF contributed more to the pathogenesis of FIPED compared with focal PED.
Effectiveness of the Sellick maneuver for painless gastroscopy in patients with esophageal hiatal hernia: a Randomized, self-control trial
Authors: Zhang Li , Shu Lei , Shi Zhaohong , Chen Zhijun
Published: December 2022

Background
Sellick maneuver is used for endotracheal intubation to prevent the occurrence of gastroesophageal reflux. Our study was to observe the effect of the Sellick maneuver on safety, esophageal closure status, gastric mucosal fold extension status, and positive detection rate of lesions in patients with esophageal hiatal hernia under painless gastroscopy.
Methods
Forty patients with esophageal hiatal hernia who underwent painless gastroscopy were screened for the Sellick maneuver, in which the operator applied pressure to the cervical cricoid cartilage during the examination. Compared with no-Sellick maneuver, we observed and recorded the status of esophageal closure at the pressing area, examination time, gastric mucosal fold extension score, positive rate of lesion detection, reflux of gastric juice or gastric contents, etc.
Results
After using the Sellick maneuver, the state of esophageal closure during gastroscopy was significantly better than the no-Sellick maneuver (P < 0.05), and the extension scores of the greater curvature folds of the gastric body, the lateral folds of the lesser curvature of the gastric body, and the mucosal folds of the fundus were significantly higher than that of the no-Sellick maneuver (P < 0.05). The number of gastric polyps examined with the Sellick maneuver was significantly more than no-Sellick maneuver(P < 0.01), and the number of gastric lesions examined (gastric ulcers, mucosal hyperplasia, etc.) was also significantly higher with the Sellick maneuver than no-Sellick maneuver (P < 0.01). The examination time was shorter with the Sellick maneuver than no-Sellick maneuver (p < 0.01). Reflux of gastric juice or gastric contents was superior to the no-Sellick maneuver (p < 0.01). The Sellick maneuver did not increase the degree of choking, as well as SPO2 variability and heart rate variability.
Conclusions
The Sellick maneuver effectively improved the extension of gastric mucosal folds during gastroscopy in patients with esophageal hiatal hernia, increased the positive detection rate of gastric lesions, and shortened the endoscopy time, while not increasing the incidence of cardia lacerations and didn’t affect the patient's voluntary breathing.
Trial registration:
The clinical trial was registered on (14/9/2022, ChiCTR2200063683)
WITHDRAWN: DOA estimation method for broadband sound sources based on multipath characteristics of shallow sea channels
Authors: Chen Hongyun , Li Xiaoman , Lu Hongyu , Mo Yaxiao
Published: December 2022

In order to improve the accuracy of direction of arrival (DOA) estimation and reduce the interference caused by multipath characteristics, this paper proposes an improved algorithm that can effectively suppress interference and improve the accuracy of direction estimation on the basis of the complex acoustic intensity target direction estimation method. The method first synthesizes the broadband pulse signal with the frequency domain acoustic pressure broadband, and after passing the synthesized signal through the channel, does the Fourier transform on it for time-frequency analysis, then does the Warping transform on the signal, separates and extracts the signal of each order of the simple positive wave to get the signal in the time domain condition, and then passes the obtained time-domain signal through the vector hydrophone separately to get the complex acoustic intensifier of the corresponding signal in the frequency domain, and finally passes the obtained Finally, the DOA estimation is carried out to obtain the average value of the complex acoustic intensity to obtain the azimuth angle.Compared with the traditional method, the proposed method can effectively suppress the interference caused by multipath characteristics and improve the accuracy of DOA estimation. Finally, the accuracy and effectiveness of the proposed method are verified by simulation and experimental data.
Landslide Susceptibility Mapping Using GIS and Bivariate Statistical Models in Chemoga Watershade, Ethiopia
Authors: Addis Abinet
Published: December 2022

In this study, landslide susceptibility mapping was carried out for Chemoga watershade upper Abay basin in Ethiopia using a bivariate statistical models of Frequency Ratio (FR) and Information Values (IV). The main objective of this study is to identified landslide susceptibility areas using GIS and Bivariate Statistical Models. Based on Google Earth imagery and filed survey, about 169 landslides were identified and classified randomly into training landslides datasets (70%) and the remaining (30%) of landslides datasets were used for validation purpose. The 10 landslides conditioning factors like slope, elevation, aspect, curvature, Topographic Wetness Index, Normalized Difference Vegetation Index, road, river, land use and rainfall were integrated with training landslides to determine the weights of each landslide conditioning factor and factor classes using both frequency ratio and information value models. The landslide susceptibility maps were produced by overlay the weights of all the landslide conditioning factors using raster calculator of the spatial analyst tool in ArcGIS 10.4. The final landslide susceptibility maps were reclassified as very low, low, moderate, high and very high susceptibility classes both FR and IV models.This susceptibility maps were validated using landslide area under the curve (AUC). The results of AUC accuracy models showed that the success rates of the FR and IV models were 0.870 and 0.901, while the prediction rates were 0.880 and 0.923 respectively. The outcome of this paper will help decision-makers for land use planning and landslide mitigation purpose in this study area.
Distribution systems reliability improvement using optimal phase balancing and economic analysis
Authors: Soltani Shirin. , Soltani Saeed. , rashidinejad masoud
Published: December 2022

Distribution systems are the most unbalanced part of the power network. This voltage unbalances can cause some major problems such as the abnormal performance of induction motors associated with their load increment, the network reliability decrease, increase in power losses, etc. So, phase balancing should be considered in distribution networks through the most effective rephasing strategy. In this paper, the optimal automatic rephasing strategy in order to improvement of distribution system reliability is investigated. On the other hand, the impacts of voltage unbalances on induction motors and their costs are optimized. Generally, this paper focuses on the system costs reduction through optimal automatic phase balancing especially in a smart environment. The proposed optimization model is solved by self-adaptive modified firefly algorithm (SAMFA). The performance of the SAMFA is compared with the ordinary firefly algorithm (FA), particle swarm algorithm (PSO) as well as genetic algorithm (GA). The proposed method is applied to the Kheibar feeder in Behbahan, Iran. Simulation studies and results analysis greatly demonstrate the significant economic benefits achieved from this research.