bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel Antifungals for the Treatment of Vulvovaginal Candidiasis: Where Are We?
Authors: Gamal Ahmed ,   Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA,   These authors have contributed equally to this work and share first authorship, Kadry Ahmed ,   Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA,   These authors have contributed equally to this work and share first authorship, Elshaer Mohammed ,   Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt, Ghannoum Mahmoud A ,   Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA,   Department of Dermatology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA
Published: December 2022

Vulvovaginal candidiasis (VVC) is a common health-related issue and the second most common cause of vaginitis. Previously, azole antifungals were the mainstay of VVC treatment. Additionally, boric acid and nystatin have been used topically for management of VVC. Despite being effective and well tolerated by most patients, the use of azoles may be limited in some cases. Currently, two new antifungal agents have received US Food and Drug Administration approval for use in the management of VVC. In this article, we briefly review treatment regimens used for the management of VVC over the past decade, the newly approved agents and their possible clinical application, and future treatment considerations.
Dapivirine Vaginal Ring for HIV Prevention in Women in South Africa
Authors: Gill Katherine ,   Desmond Tutu HIV Centre, University of Cape Town, South Africa, Bekker Linda-Gail ,   Desmond Tutu HIV Centre, University of Cape Town, South Africa
Published: December 2022

Young women remain disproportionately affected by the HIV epidemic in South Africa. Clinical trials have shown that the dapivirine vaginal ring (DVR) is safe and effective at reducing HIV infection in women. In March 2022, the South African Health Products Regulatory Authority approved the use of the DVR in women aged 18 years and older who are unable or unwilling to use oral pre-exposure prophylaxis, as an additional choice for preventing HIV in women at substantial risk. Modelling studies have suggested that the DVR could have a substantial impact if prioritized for women at substantial risk of HIV or women aged 22–29 years. The licensing of the DVR in South Africa is a milestone event that brings the first long-acting and woman-controlled HIV prevention method another step closer to reaching the people who need it. As South Africa prepares its introduction, it is critical to examine the unmet need for HIV prevention and to review the clinical trial data that led to the DVR's approval.
HIV Prevention Utilizing Long-acting Injectables
Authors: Egelund Eric F ,   Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Jacksonville, FL, USA,   Infectious Disease Pharmacokinetics Laboratory, Gainesville, FL, USA, Huston Jessica ,   Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Jacksonville, FL, USA
Published: December 2022

Pre-exposure prophylaxis (PrEP) is an essential component in ending the HIV pandemic. Unfortunately, PrEP uptake has not been optimal to date. This is due to various reasons, one of which is adherence. Long-acting injectables may help to overcome this barrier. This brief review discusses the long-acting injectables currently in use for PrEP (cabotegravir) and HIV treatment (cabotegravir and lenacapavir), as well as those currently undergoing clinical trials. Other promising agents are being studied, including islatravir and broadly neutralizing monoclonal antibodies. Furthermore, agents currently used for HIV treatment will likely be evaluated in preclinical and clinical studies for their use as PrEP agents.
Isolated Tuberculosis of the Ribs in an Immunocompetent Adult
Authors: Rajkumar Venkatraman ,   Banting Clinic, Chennai, Tamil Nadu, India
Published: December 2022

Skeletal involvement is a frequent site of extrapulmonary tuberculosis, but an isolated disease of the ribs is rare. This case report studied an adult immunocompetent male patient who presented with constitutional symptoms, pain and point tenderness in two ribs. The diagnosis of rib tuberculosis was delayed due to earlier providers not recognizing the condition. Routine chest X-rays performed in the early stages of the disease did not reveal abnormalities, but computed tomography did. The patient had lytic rib lesions and a swelling of the chest wall soft tissue consistent with a cold abscess. Specifically, the scan was significant for the absence of involvement of the lung, pleura, spine and mediastinal lymph nodes. While routine smears and cultures were negative, a polymerase chain reaction test for Mycobacterium tuberculosis performed on a sample of aspirate from the swelling confirmed the diagnosis. The patient responded to anti-tuberculous drug therapy, made a complete recovery without complications or the need for surgery and has now been disease free for 16 years. The patient had no concomitant pulmonary disease and was not immunocompromised. The timely intervention could prevent complications. This case report reviews literature and recent research on rib tuberculosis. If these research findings are replicated in larger studies, it will pave the way for more effective management of this rare condition.
Board of Directors
Authors: BHAC Journal Building Healthy Academic Communities
Published: December 2022

No abstract available.
Topical steroid induced Cushing’s syndrome-a rare entity
Authors: Gopi Manigandan , Seshadri M. S.
Published: December 2022

The topical steroid therapy is the commonest mode of treatment for Psoriasis. When the therapy is overused, it can cause unusual side effects like Cushing’s syndrome which is very rarely reported and we are reporting such a case. Treatment with maintenance dose of steroids is necessary based on basal cortisol levels to avert hypocortisolemic crisis in Cushing’s syndrome, however in some select asymptomatic cases maintenance dose of steroids can be withdrawn and only stress dose be given in spite of low basal serum cortisol. We managed such a case and it is reported because of its rarity in clinical practice. This can alert the clinicians to avoid prescribing steroids as maintenance dose for a long time in asymptomatic Cushing’s syndrome with low morning cortisol and thereby reducing the side effects of long-term steroids on them.
The Role of Intellectual Capital in Firms’ Performance and Market Value: Evidence from Jordan
Authors: Odat Mahmoud , Bsoul Ruba
Published: December 2022

The purpose of this study is to examine the association between intellectual capital efficiency and firms’ financial performance and market value. The study employs the value-added intellectual coefficient (VAIC) model to measure intellectual capital efficiency. This model consists of three elements: human capital efficiency, structural capital efficiency, and capital employed efficiency. The study uses the return on assets (ROA) ratio to measure firms' financial performance and the market-to-book value (MBV) ratio as a measure of market value. Data for a sample of 113 manufacturing and service companies listed on the Amman Stock Exchange for 2014 to 2018 were analyzed using multiple regression analysis. The results indicate that VAIC has a significant positive relationship with a firm’s financial performance, while it is unrelated to a firm’s market value. Human and structural capital also have a positive influence on financial performance, but they have no relationship with market valuation. Capital employed is positively related to both financial performance and market value. The findings of this study would enable companies to better understand the role of intellectual capital in adding value for all stakeholders of the company. They may also bring standard setters’ attention to the need for recognizing or disclosing intellectual capital either quantitatively or qualitatively within the accounting financial reports, which may have the potential to increase the credibility of financial reporting.
Numerical study of the filtering barriers influence to contain aerated particulate systems
Authors: M. T. M. Oliveira Leonardo , L. S. Duarte José , B. Bernardo Vanderson , Porto Moura Andreza , Alves de S. Neto Aureo , J. S. Fonseca Eduardo , F. A. M. Oliveira Laís
Published: December 2022

Since the high rate of viral proliferation caused by Covid-19, it was observed that microdroplets with a pathogenic load can remain floating when in confined environments due to their low densities. They are also subject to being transported very easily when in open environments, becoming potential agents of infection. It has motivated several researchers in the field of particulate systems to try understand how particles behave in more extreme conditions. Bearing in mind that the materials currently used have a low retention yield for liquid droplets, and that protection barriers against pathogens are present both in daily use in hospital application, from diagnosis to treatment, this work simulated computationally, in a Eulerian-Eulerian approach, fluid particle retention efficiency in filter films. The simulated results indicated the high degree of retention of the filtering medium and the dependence of its saturation on the particle diameter and flow velocity, in which the greater the initial flow velocity and larger particles, the faster the saturation and detachment of particles, reducing the filter medium containment capacity. However, the results indicated that even so, retainer materials are efficient in reducing the proliferation of pathogenic loads.
Community Facilitator: Human Resources Or Human Capital?
Authors: Prihatin Taat P. , Purwana Dedi , Buchdadi Agung Dharmawan
Published: December 2022

Community Facilitator is indispensable in the development programs that use a community-based approach. Its existence has been an integral part of community-driven development since the early 1980s. The question is, is it human resources or human capital? What competencies must a facilitator have to carry out their duties effectively? This research was conducted with a qualitative approach through FGD and interviews with informants to answer the following questions: (i) what is a facilitator? (ii) how does the facilitator work? (iii) what competencies must the facilitator have? (iv) what is the difference between human resources and human capital? (v) is the facilitator a human resource or human capital? In this research, the facilitator's competence will be identified using the KSA framework (knowledge, skill, and attribute).

Based on the study, a facilitator is defined as a person with certain knowledge, skills, and attributes, who is assigned to introduce, plan, and organize the implementation of a program to the program beneficiaries so that the program can be implemented following the predetermined budget, provisions, quality,  and procedures. Facilitators must know the program cycle, local culture/tradition, formal and informal figures in the village, and the resources required for the program implementation. The facilitator's must-have skills include communication, organizing, mediation, administration-finance, and various construction technical skills. Meanwhile, the attributes needed include commitment, responsibility, and adaptation.

A human resource is a worker using knowledge, skills, and commitment to carry out tasks with clearly defined processes and outputs. Human capital is a worker who uses knowledge, skills, creativity, innovativeness, and commitment to carry out tasks to increase the organizational value-added, with processes and outputs that have not been clearly defined. From an individual and organizational perspective, community facilitator is categorized as human capital.
The Enemy Other: Discourse of Evil in William Shakespeare’s "The Tempest"
Authors: Abu-Shomar Ayman
Published: December 2022

Caliban, the ‘enemy Other’ of William Shakespeare’s The Tempest, is a character that allows further investigations of the colonial ideology in its earliest forms; locating ‘evil’ forces outside the continent of Europe and the White race. Caliban, the only non-European character, is typified as the autocratic antagonist of the play whose evil intentions and actions cannot be redeemed. Against such representation, the essay argues that the villainous discourse attributed to Caliban is informed by Renaissance theological doctrines escorted by an emergent colonial ideology. It argues that, at a semantic level, the employment of the concept of ‘evil’ often serves as an intensifier to denounce wrongful actions. At a moral level, however the term is often contested on the basis that it involves unwarranted metaphysical commitments to dark spirits necessitating the presence of harmful supernatural creatures. To attribute the concept to human beings is therefore essentially problematic and dismissive since it lacks the explanatory power of why certain people commit villainous actions rather than others. Hence, the epistemological aporia of Caliban’s ‘evil’ myth reveals an inevitable paradox, which concurrently requires locating Caliban both as a human and unhuman figure. Drawing on a deconstructionist approach, the essay puts the concept of ‘evil’ under erasure, hence, argues that Caliban’s evilness is a mere production of rhetoric and discourse rather than a reality in itself. This review contributes to the intersecting areas of discourse, representations, and rhetoric of evil within the spectrum of postcolonial studies.
Contacto social y lingüístico: el español en contacto con el quechua en el Perú
Authors: Escobar Anna María
Published: December 2022

Este libro constituye un replanteamiento novedoso, tanto conceptual como metodológico, de los problemas que enfrenta el estudio del castellano andino. Su autora propone abordar el estudio del castellano que surge con del contacto con el quechua, no sólo situándolo dentro del contexto histórico-cultural y demográfico de la sociedad peruana, sino teniendo en cuenta -y aquí lo novedoso del asunto- factores lingüísticos que rebasan el concepto mecanicista de las estructuras formales de ambas lenguas para tomar consideración de aspectos propios de la epsteme que subyace a aquéllas.
Los mecanismos de articulación y coordinación intergubernamental de Políticas Nacionales y Territoriales en el Perú
Authors: Chessman Olaechea Yuri Alejandro
Published: December 2022

La implementación de las políticas públicas en el Perú es la mayor debilidad del proceso de descentralización y la gestión pública debido a la ineficacia de las instancias, las plataformas o los espacios de articulación y coordinación donde las autoridades gubernamentales de los tres niveles de gobierno (nacional, regional y local) no han logrado consensos y/o acuerdos para establecer una visión compartida del desarrollo territorial en busca de cerrar las desigualdades económicas y sociales. Este artículo presenta el análisis de los últimos años, en especial de los años 2021 y 2022, sobre los nuevos mecanismos de articulación, como lo es el Consejo de Coordinación Intergubernamental (CCI) que, a través de sus instancias operativas, tales como el GORE Ejecutivo, el MUNI Ejecutivo, otros Encuentros Intergubernamentales (Reuniones Ejecutivas, Mesas Técnicas de Desarrollo y Consejos de Ministros Descentralizados) y la nueva versión de las Comisiones Intergubernamentales, se presentan como un nuevo intento para articular las políticas y las estrategias nacionales y territoriales a través de una efectiva gobernanza multinivel y multiactor que tenga como finalidad fortalecer la gestión descentralizada.
Políticas Públicas para la gestión de conflictos: entre la institucionalización y el estancamiento
Authors: Huamani Ober Giselle , Macassi Lavander Sandro
Published: December 2022

En el presente artículo, los autores analizan el rol de las diversas estrategias de gestión de conflictos planteadas por los gobiernos del Perú durante los últimos veinte años desde un enfoque basado en las políticas públicas y en su sostenibilidad. Así, en primer lugar, presentan las fases del problema público y su relación con el proceso de producción de políticas públicas. En segundo lugar, se analiza el desarrollo presentado durante las gestiones presidenciales en lo relacionado a la gestión de conflictos y a la producción de políticas públicas relacionadas a ello. Finalmente, se presentan las conclusiones pertinentes.
Educación virtual durante la emergencia sanitaria
Authors: Moreno Jacqueline Elizabet , Chiecher Analía Claudia
Published: December 2022

La propagación del COVID-19 produjo una crisis mundial sin precedentes en todos los ámbitos, especialmente el educativo. En respuesta al cese de las actividades presenciales, los recursos virtuales se consagraron como medios fundamentales para garantizar los aprendizajes. Ante esta realidad, el estudio que se presenta en este artículo se propone explorar y describir las valoraciones positivas y negativas de ingresantes universitarios luego de cursar el primer cuatrimestre, teniendo que afrontar el cambio obligatorio en la modalidad de sus estudios, pasando de una enseñanza presencial, a una enteramente virtual. Participaron 199 ingresantes a carreras de ingeniería de la Universidad Nacional de Río Cuarto de las cohortes 2020 y 2021. Los datos fueron recabados a partir de un cuestionario online sobre trayectorias académicas en el primer año. Se analizaron preguntas abiertas desde una lógica cualitativa, con el soporte del software Iramuteq. Los resultados muestran que la virtualidad favoreció la apropiación de múltiples recursos web que antes de la pandemia eran totalmente desconocidos o poco considerados como una alternativa para la enseñanza y el aprendizaje. Como aspectos positivos, los estudiantes valoraron la posibilidad que les otorgó la virtualidad para garantizar la continuidad de los aprendizajes —principalmente a través de las clases por videollamada—, flexibilizar y organizar los propios tiempos, desarrollar estrategias de autoaprendizaje y proporcionar comodidad. Entre los aspectos negativos, los estudiantes señalaron la imposibilidad de rendir exámenes, dificultades en la comprensión, ausencia de instancias prácticas y baja calidad de las interacciones a pesar de los múltiples canales alternativos de comunicación.
Responsabilidad social empresarial y América Latina: una revisión de literatura
Authors: Osorio Mogollón Jonathan , Mogrovejo Andrade Johanna Milena , Duque Pedro
Published: December 2022

The purpose of this study is to review the literature associated with research on Corporate Social Responsibility and Latin America through a scientific mapping analysis supported by bibliometric tools. The methodology applied consists of a search in the Web of Science database, followed by analyzing and classifying documents through the tree analogy. This classification comprises three groups organized as root, trunk, and leaves, established explicitly as classic, structural and recent documents. Each group analyzes the impact and relevance of the topic of CSR. The results reveal the structure of this area of knowledge, thus finding an approach that can provide conceptual guidance to companies interested in opting for CSR strategies within the framework of disclosure, financial performance, and sustainable development.
Yağ Gülü (Rosa damascena Miller)’nde GA3 Uygulamalarının Verim ve Kalite Özelliklerine Etkisi
Authors: Efecan Süleyman , Erbaş Sabri , Mutlucan Murat
Published: December 2022

Çalışmada yağ gülünde farklı dozlarda GA3 uygulamasının verim ve kalite özelliklerine üzerine etkisinin belirlenmesi amaçlanmıştır. Çalışmada yağ gülü bitkilerine tomurcuklanmaya başladığı ve pembe renkli petallerin sepallerden çıkmaya başladığı dönemde ve bu tarihten bir hafta sonra beş farklı dozda (0, 25, 50, 75, 100 ppm) GA3 uygulanmıştır. Bitkilerden çiçeklenme başında (1-7. gün), ortasında (8-14. gün) ve sonunda (15-21. gün) olmak üzere üç dönemde çiçek hasadı yapılmıştır. Bitkilerde çiçek çapı, petal oranı, 100 çiçek ağırlığı ile çiçek ve uçucu yağ verimi 50 ppm GA3 dozuna kadar artış göstermiştir. Çiçeklerdeki uçucu yağ oranı 25 ppm dozuna kadar artmış, sonraki dozlarda ise azalmaya başlamıştır. Uçucu bileşenleri, çiçeklenme başlangıcında kontrolden 100 ppm uygulamasına kadar geraniol oranı % 36.69’dan %21.16’ya, çiçeklenme ortasında %27.34’ten %12.93’e ve çiçeklenme sonunda ise %22.33’ten %21.14’e gerilemiştir. Çiçeklenme başlangıcında nonadesen ve nonadesan oranı kontrolden 100 ppm dozuna kadar sırasıyla % 1.44’ten %2.47’ye ve %16.50’ten %23.58’e, çiçeklenme ortasında %1.69’dan % 2.66’ya ve %17.15’ten %21.23’e yükselmiştir. Çiçeklenme sonunda ise nonadesen oranı %2.56’dan %1.87’ye düşerken, nonadesan oranı %20.66’tan %29.45’e yükselmiştir. Sonuç olarak; yağ gülünde yüksek çiçek ve uçucu yağ verimi ile uçucu yağ bileşenlerinin elde edilmesinde 25 ppm GA3 uygulanması önerilebilir.
A Heterocyclic Compound Hispidulin: Theoretical Investigation by DFT/TD-DFT Methods and Molecular Docking Studies
Authors: Ata Ahmet Çağrı , Tanrıverdi Aslıhan Aycan , Yıldıko Ümit , Çakmak İsmail
Published: December 2022

Flavonoids are polyphenolic plant secondary metabolites with biological properties including Alzheimer's disease (AD) inhibition activities. Numerous studies have been conducted on naturally occurring flavonoids modified to obtain effective drugs for the management of AD. In this study, DFT/B3PW91, TD-DFT/B3LYP methods of target molecule hispidulin 4′,5,7-Trihydroxy-6-Methoxyflavone (THMF) and LANL2DZ (d,p), 6-311G (d,p) basic HOMO-LUMO energy calculations, optimized molecular geometry, molecular electrostatic potential surface (MEPS), non-linear optics (NLO), charge transfer within the molecule and mulliken atomic charges structure were determined and the results were displayed. Moreover the identification of the mechanism of action of the tested compound based on the structure-activity relationship with the molecular docking process is to provide important information to be considered for further research, and thus to design new, more efficient and selective systems.
Theoretical and legal characteristics of modern global challenges and threats in the field of healthcare
Authors: Kholikov Ivan V.
Published: December 2022

The purpose of the study is to identify and substantiate the international legal characterization of modern challenges and threats in the field of public health. The relevance of the study lies in the fact that the international situation as a whole cannot be characterized as favorable. Demographic problems are growing in the world, poverty, hunger, lack of drinking water are becoming more and more widespread. The question of the emergence of new and the return of already seemingly conquered diseases is acute. Epidemics and pandemics have a complex of causes, conditions and consequences of a political, medical, technological, psychological, economic, social and organizational nature. It is substantiated that one of the real trends in social practice is the problem of the spread of epidemics, pandemics and mass diseases as a possible basis for the international responsibility of states and international organizations. An important legal aspect is the use of the actions of individual states and international organizations. One of the ways out of the crisis is seen in the constant and timely strengthening of national health systems, on the basis of which it was concluded that this will ensure early forecasting of emerging threats, the development of appropriate measures and their localization.
Students’ Perceptions of Innovative Learning Media as a Support System for Inclusive Education
Authors: Amalia Yuni Sari
Published: December 2022

All students, without exception, are expected to have an equal opportunity of acquiring higher education. Many universities in Indonesia including Universitas Airlangga accept students with disabilities. However, the availability and use of learning materials for these students are scarce. The study aimed to understand the students' perceptions on this issue, particularly for students with visual and hearing impairments. The study includes 80 participants consisting of regular students and students with special needs in Universitas Airlangga. The study used a questionnaire to collect students’ perspective on learning media provided by Universitas Airlangga. The findings of the study revealed how the majority of students at Universitas Airlangga considered learning materials and media available cannot be used to its full potential by students with special needs. Moreover, the policies have not been adjusted to the needs of students with special needs. Moreover, students expected support system to help the learning process of students with special needs. Lastly, the participants’ responds on the questionnaire show positive opinions on the initiative and calls for the need to scale up and improve the support system.
Accessibility of Archival Reference Services
Authors: Indrasweri Nindya , Dwi Wahyuni Elya Riska , Rakhmawati Rina
Published: December 2022

Background of the study: Archival services are the final stage of records management, if they are based on an archive lifecycle approach. Accessibility aspects need to be studied in an effort to optimize archiving services so that archives can be widely used by the community.
Purpose: This paper describes the process of archiving services and the accessibility aspects of archiving services carried out by Dinas Perpustakaan dan Kearsipan Kabupaten Sleman.
Method: This research was a descriptive qualitative approach. Data was collected through observations, interviews, and literature studies. The data then has been analyzed in the following stages: observing the data, developing general sense, coding, compiling a narrative framework for presenting the results of data interpretation, and interpreting the data using data triangulation techniques.
Findings: The accessibility aspect of archiving services at the Sleman Regency Library and Archives Service is viewed from four indicators, namely policies, facilities and infrastructure, service personnel, and archive user satisfaction. In policy indicators, the agency has been guided by legal products that are applied to technical archiving services, both at local and national levels. In terms of facilities and infrastructure indicators, in general, the department has met the minimum standard of availability and condition of archival service facilities and infrastructure.
Conclusion: There are limitations in this study, namely the limitations of the analysis of each indicator which does not describe in depth so that archival services in the office are declared affordable. In addition, it is necessary to carry out a critical analysis of the results of the user satisfaction survey, namely through in-depth interview techniques to comprehensively understand the archive service process at the office.
The Implementation of Covid-19 Archives Preservation in College
Authors: Lolytasari Lolytasari , Irfaniah Hikmah
Published: December 2022

Background of the study: Circular Letter No. 62 of 2020 concerning the Preservation of Covid-19 handling archives is a public policy that needs to be implemented by State Universities as part of government agencies.
Purpose: This study aims to explore efforts to implement policies to preserve the records of Covid-19 handling at university and understand the challenges it faces as university that does not have its own Archive yet.
Method: This study uses a qualitative approach with a case study method. There are three informants selected through the purposive sampling method. Informants were selected based on the following criteria: 1) has mandatory duties in archival activities and 2) positioned as an archivist. Research data obtained through interviews and documentation studies
Findings: The university efforts in preserving Covid-19 handling archives are carrying out internal communication to preserve archives within the General, increasing archivists’ competencies and knowledge, and conducting from preparation to Covid-19 archives assessment. Related efforts in the organizational structure have not been made because this process takes a long time. The challenges arise from the lack of human resources in every unit of PTN X and the absence of an archival institution which makes it difficult to implement implementation in all units of university
Conclusion: The university has made efforts to preserve the handling of Covid-19 within the smaller scope, the General Bureau. For a wider scope, the implementation has not been carried out due to lack of human resources and the absence of university Archive owned by university.
Keywords: archives preservation, Covid-19 archives, public policy, university archives
Quality assurance and its impact from higher education institutions’ perspectives
Authors: Sabban Irawati , Abd Rahman Irfan Hi.
Published: December 2022

Background of the study: The implementation of quality assurance at Morotai Pacific University does not improve and improve the quality of higher education implementation in the Border Area of Morotai Island Regency. This is evidenced by until now the University of the Pacific Morotai does not have university accreditation.
Purpose: This research aims to find objective, accountable evidence in helping universities make improvements in developing quality universities and improve strategies in carrying out quality assurance at the college.
Method: This research uses mixed methods with sequential explanatory strategies implemented of alumni at the Morotai Pacific University of North Maluku as the Border Region of the Republic of Indonesia.
Findings: The results showed that there are still many graduates of pacific morotai universities who do not have a job, and are looking for work. While the perspective of alumni on ability in the academic field is focused on aspects of graduates who have special competencies, general competence, personality competence, and infrastructure. The addition of teaching staff is also one of the concerns of alumni to meet the ratio of lecturers to students.
Conclusion: This article defines the essence of the parameters and dimensions of quality assurance of universities in Indonesia, especially at the Morotai Pacific University in North Maluku through the application of quality assurance models.
ILMU JIWA FALSAFI BERBASIS AL-QUR’AN SEBAGAI SUATU DISIPLIN ILMU
Authors: Gama Cipta Bakti
Published: December 2022

Studying multiple dimensions of the human self requires an integration-interconnection between rational, scriptural, Sufistic, and empirical disciplines of knowledge. Many muslim psychologists have long developed an integrative study known as Islamic Psychology. Such integration pivots on Modern Psychology as an empirical discipline (science) which absorbs various Islamic studies on human soul, mind, behavior, and the like, so that there is still room for integration focused on philosophical and scriptural disciplines. This paper contains the initial ideas of constructing a discipline of knowledge on the human self that pivots on the integration between Islamic Philosophy and Quranic Exegesis, which is called Quran-Based Philosophical Psychology. The findings of this paper include the formulation of a number of principles as the Basic Structure of Knowledge underlying the Quran-Based Philosophical Psychology, which is based on the idea of Logic about the components of knowledge and the idea of the Philosophy of Science about the relationship between disciplines and their social aspects.
Near Infrared Efficiency Enhancement of Silicon Photodiodes by Integration of Metal Nanostructures Supporting Surface Plasmon Polaritrons
Authors: Scattolo Elia , Cian Alessandro , Petti Luisa , Lugli Paolo , Giubertoni Damiano , Paternoster Giovanni
Published: December 2022

Recently, the interest in silicon-based detectors capable of detecting single photons in the near-infrared is growing mainly due to LiDAR applications, autonomous driving in particular. Silicon single-photon avalanche diodes are one of the most interesting single-photon NIR technology available on the market, nevertheless, their efficiency is hindered by the low absorption coefficient of Si in the NIR. The idea is the integration of CMOS-compatible nanostructures, specifically, silver grating array supporting Surface Plasmons Polaritons (SPPs), to confine superficially the incoming NIR photons and therefore increase photons probability to generate an electron-hole pair. The plasmonic silver array is geometrically fine-tuned using time domain simulation software to achieve maximum detector performance at 950 nm. Then, the plasmonic silver array is integrated by means of the focused ion beam technique on the detector. Finally, the integrated detector is electro-optically characterized, demonstrating a quantum efficiency of 13 at 950 nm, 2,2 times more than the reference detector. This result suggests the production of a device capable of detecting single NIR photons, at a very low cost and compatible with CMOS, thus integrable on existing technology platforms.
The Succession of the Cellulolytic Microbial Community from the Soil during Oat Straw Decomposition
Authors: Kimeklis Anastasiia K. , Gladkov Grigory V. , Orlova Olga V. , Afonin Alexey M. , Gribchenko Emma S. , Aksenova Tatiana S. , Kichko Arina A. , Pinaev Alexander G. , Andronov Evgeny E.
Published: December 2022

The decomposition of straw is a dynamic process, which is reflected in the decomposing microbial consortia, however, this process is poorly understood. Here we performed an experiment on the gradual colonization of oat straw by the soil microbial community. The results showed that soil respiration and bacterial diversity were negatively correlated – while the first decreased, the latter increased. In accordance with the dynamics of diversity and respiration, succession was divided into early, middle, and late decomposition phases. Analysis of 16S rRNA and ITS2 amplicon sequencing data revealed three jointly changing groups of phylotypes, corresponding with distinguished phases of decomposition. The presence of cellulolytic members of Proteobacteria, Bacteroidota, Firmicutes, and Actinobacteriota for bacteria and Ascomycota for fungi had been detected since the early phase, but most of the initial phylotypes were gone by the end of the phase. The second phase marked the functional core with a constant set of other phylotypes from these phyla, persisting in the community. Full metagenome sequencing of the microbial community from the end of the middle phase confirmed that major members of this consortium had GH genes, connected to cellulose and chitin degradation. The appearance of non-cellulolytic members from Bdellovibrio, Myxococcota, Chloroflexi, and Crenarchaeota characterized the last phase of the mature community.
The Genetic Mechanisms Underlying the Concerted Expression of the Yellow and Tan Genes in Complex Patterns on the Abdomen and Wings of Drosophila Guttifera
Authors: Raja Komal K.B. , Bachman Evan A , Fernholz Catrina , Trine David , Hobmeier Rebecca E. , Maki Nathaniel , Massoglia Timothy , Werner Thomas
Published: December 2022

How complex morphological patterns form is an intriguing question in developmental biology. However, the mechanisms that generate complex patterns remain largely unknown. Here we sought to identify the genetic mechanisms that regulate the tan (t) gene in a multi-spotted pigmentation pattern on the abdomen and wings of Drosophila guttifera. Previously, we showed that yellow (y) gene expression completely prefigures the abdominal [1] and wing [2] pigment patterns of this species. In the current study, we demonstrate that the t gene is co-expressed with the y gene in nearly identical patterns, both transcripts foreshadowing the adult abdominal and wing melanin spot patterns. We identified cis-regulatory modules (CRMs) of t, one of which drives reporter expression in six longitudinal rows of spots on the developing pupal abdomen, while the second CRM activates the reporter gene in a spotted wing pattern. Comparing the abdominal spot CRMs of y and t, we found a similar composition of putative transcription factor binding sites that are thought to regulate the complex expression patterns of both terminal pigmentation genes y and t. In contrast, the y and t wing spots appear to be regulated by distinct upstream factors. Our results suggest that the D. guttifera abdominal and wing melanin spot patterns have been established through the co-regulation of y and t, shedding light on how complex morphological traits may be regulated through the parallel coordination of downstream target genes.
Antiracism and Community-Based Participatory Research: Synergies, Challenges, and Opportunities
Authors: Fleming Paul J. , Stone Lisa Cacari , Creary Melissa S. , Greene-Moton Ella , Israel Barbara A. , Key Kent D. , Reyes Angela G. , Wallerstein Nina , Schulz Amy J.
Published: December 2022

Structural racism causes stark health inequities and operates at every level of society, including the academic and governmental entities that support health research and practice. We argue that health research institutions must invest in research that actively disrupts racial hierarchies, with leadership from racially marginalized communities and scholars.

We highlight synergies between antiracist principles and community-based participatory research (CBPR), examine the potential for CBPR to promote antiracist research and praxis, illustrate structural barriers to antiracist CBPR praxis, and offer examples of CBPR actions taken to disrupt structural racism. We make recommendations for the next generation of antiracist CBPR, including modify health research funding to center the priorities of racially marginalized communities, support sustained commitments and accountability to those communities by funders and research institutions, distribute research funds equitably across community and academic institutions, amplify antiracist praxis through translation of research to policy, and adopt institutional practices that support reflection and adaptation of CBPR to align with emergent community priorities and antiracist practices.

A critical application of CBPR principles offers pathways to transforming institutional practices that reproduce and reinforce racial inequities. (Am J Public Health. 2023;113(1):70–78. https://doi.org/10.2105/AJPH.2022.307114 )
Hitos turísticos urbanos y su representación en las producciones audiovisuales: el caso de España (2000–2021)
Authors: Osácar Marzal Eugeni , Puche-Ruiz Maria C. , Martínez Puche Salvador
Published: December 2022

Esta investigación tiene como principal objetivo conocer el grado de coincidencia entre los hitos o lugares de más interés turístico y los espacios urbanos representados en las principales producciones audiovisuales rodadas en el siglo XXI. El trabajo se basa en algunas de las ciudades más relevantes a nivel turístico de la geografía española, así como en territorios insulares de especial importancia turística. La investigación es de naturaleza analítico-descriptiva, con una metodología cuantitativa y la utilización de la técnica de observación científica. Uno de los principales resultados obtenidos es la existencia de un alto grado de coincidencia entre algunas de las localizaciones proyectadas en las películas y series seleccionadas con los lugares de más interés turístico de las ciudades e islas analizadas.
Dampak Pembelajaran Daring di Era Pandemi Covid-19 pada Mahasiswa Tadris Ilmu Pengetahuan Alam IAIN Ponorogo
Authors: Iqbal Muhammad , Sari Fika Septiana
Published: December 2022

Pandemi virus Covid-19 yang melanda banyak negara di dunia termasuk di Indonesia memberikan bebagai pengaruh di bidang pemerintahan Indonesia termasuk pada bidang pendidikan. Pembelajaran dengan sistem daring merupakan sebuah solusi dari pemerintah untuk menanggulangi penyebaran dari virus ini agar pendidikan tetap dapat berjalan. Namun, dalam pelaksanaannya pembelajaran daring ini juga berdampak pada berbagai aspek dalam perkuliahan mahasiswa. Oleh karena itu peneliti tertarik untuk melakukan penelitian tentang apa saja dampak dari pembelajaran daring ini pada mahasiswa Tadris IPA IAIN Ponorogo. Metode yang digunakan dalam penelitian ini adalah kualitatif  deskriptif dengan teknik wawancara dan survey terhadap responden yaitu mahasiswa IAIN Ponorogo dari angkatan 2017-2020. Hasil dan kesimpulan dari penelitian ini menunjukkan pembelajaran daring memberikan dampak yang positif seperti menjaga jarak agar terhindar dari virus Covid-19, menambah pengalaman dengan sistem pembelajaran baru, dan menghemat anggararn dalam melaksanakan perkuliahan. Sedangkan dampak negatif dari sistem daring ini adalah bisa terganggunya kesehatan mata karena sistem daring menggunakan media layar hp dan laptop yang cukup lama, susahnya beberapa materi dipahami karena menggunakan sistem daring, dan ketergantungan dengan sinyal karena sistem pembelajaran daring sangat membutuhkan sinyal yang baik.
Norepinephrine combined with phenylephrine versus norepinephrine in patients with septic shock: a retrospective cohort study
Authors: He Dan , Zhang Luming , Lu Xuehao , Gu Wan-jie , Yin Haiyan , Hu Hai , Hong Liang , lyu Jun
Published: December 2022

BACKGROUND Phenylephrine (PE) and norepinephrine (NE) may be used to maintain adequate blood pressure and tissue perfusion in patients with septic shock, but the effect of NE combined with PE (NE-PE) on mortality remains unclear. We hypothesized that NE-PE would not inferior to NE alone for all-cause hospital mortality in patients with septic shock.
METHODS This single-center, retrospective cohort study included adult patients with septic shock. According to the infusion type, patients were divided into the NE-PE or NE group. Multivariate logistic regression, propensity score matching and doubly robust estimation were used to analyze the differences between groups. The primary outcome was the all-cause hospital mortality rate after NE-PE or NE infusion.
RESULTS Among 1, 747 included patients, 1, 055 received NE and 692 received NE-PE. For the primary outcome, the hospital mortality rate was higher in patients who received NE-PE than in those who received NE (49.7% vs. 34.5%, p<0.001), and NE-PE was independently associated with higher hospital mortality (odds ratio=1.75, 95% confidence interval=1.35–2.27, p<0.001). Regarding secondary outcomes, patients in the NE-PE group had longer lengths of stay in ICU and hospitals. Patients in the NE-PE group also received mechanical ventilation for longer durations.
CONCLUSIONS NE combined with PE was inferior to NE alone in patients with septic shock, and it was associated with a higher hospital mortality rate.
Study on Surface Structure Characterization and Stability of α-AlH3 coated with PW
Authors: QIN Mingna , TANG Wang , CHEN Yajie , WANG Wei , ZhANG Yan , GUO Tao , SHI Qiang
Published: December 2022

Alpha-aluminum hydride (a-AlH3) is usually metastable due to the small enthalpy of formation, poor stability, high chemical activity, sensitive to moisture, easy to combine with water in the air. In order to inhibit the hygroscopicity of α-AlH3 and improve its storage and stability, PW (paraffin wax) is selected as the coating material, and the solvent-non-solvent method is used to coat the surface of α-AlH3. The structure and topography of α-AlH3 before and after coating are characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffractometer (XRD), X-ray electron spectroscopy (XPS), elemental analysis, and scanning electron microscopy (SEM). The results show that PW forms a uniform and complete coating layer on the surface of α-AlH3, and the crystal structure and morphology of the α-AlH3 samples after the coating are not changed, and the moisture absorption weight gain rate is reduced from 12% before the coating to 0.05%, and the hygroscopicity is greatly reduced. Furthermore, the a-AlH3 coated by PW also shows excellent performance in resisting water erosion, and the hydrophobic angle increases from 27° to 98° after the PW is coated on the a-AlH3 surface. This research provides a easy method for the safe application of a-AlH3 in the field of solid propellants.
Monitoring of surface roughness evolution during abrasive flow machining by acoustic emission
Authors: HAN Sangil , Salvatore Ferdinando , Claudin Christophe , Rech Joël , Wosniak Fabio , Matt Patrick
Published: December 2022

Abrasive flow machining (AFM) is very effective and widely adopted superfinishing process of internal channel surfaces in industry. There have been high demands for process monitoring of surface roughness evolution during AFM, as the evolution of surface roughness is sensitive to AFM media variables, such as abrasive grain size and concentration, as well as process duration. Acoustic emission (AE) is known to be a promising tool to detect microscale deformation mechanisms arising from abrasion. This work has shown there is a close correlation, during AFM with different media, between the evolution of surface roughness and material removal with the AE root-mean-square (RMS) and AE fast fourier transform (FFT) signals. Moreover, AE signals are correlated to wear mechanisms, such as ploughing and cutting mechanisms.
Lessons learnt from an unsuccessful feasibility trial for of an addictive behaviour change program for young people
Authors: McCarter Kristen , Lum Alistair , Damianidou Despoina , Bailey Kylie , Cassel Stephanie , Unwin Katherine , Beck Alison , Kelly Peter J. , Argent Angela , Deane Frank P. , Langford Sophie , Baker Amanda L
Published: December 2022

Background
Recruiting young people to addiction research trials poses considerable challenges. Multiple referral pathways across a range of systems, financial incentives, and social media advertisements can improve recruitment outcomes in youth research. In this study, we aimed to assess the feasibility of recruitment to a youth-targeted addiction behaviour change program.
Methods
Our target sample size was 20 participants. We recruited via a youth mental health treatment service and paid Facebook advertisements with financial compensation for completion of baseline and post-intervention assessments. The program was a youth-tailored version of Self-Management and Recovery Training (SMART Recovery) that was based on our program development work that included interviews with SMART Recovery facilitators and young people. We assessed feasibility of recruitment as the as primary outcome.
Results
During the recruitment period (October 1st and October 28th, 2021) we recruited one young person. Due to funding-related constraints on timing and staffing, we abandoned the trial.
Conclusions
Our recruitment efforts failed to enrol sufficient participants required for successful trial delivery. A critique of our recruitment procedures identified multiple factors that help explain these poor outcomes, including that we engaged only one referring service and did not assess buy-in among clinicians at this service; our program may have attempted to reach too broad an audience by targeting health behaviour change rather than specific addictive behaviours; and that we did not mention the financial incentives of participation in our Facebook advertisements. This study provides important insights to guide future recruitment efforts targeting young people to addiction treatment trials.
Trial registration
The trial was registered with Australian and New Zealand Clinical Trial Registry prior to recruitment (ACTRN12621001283864).