bluuebunny/crossref_metadata_2025 huggingface dataset:
Two New Species of Serjania (Sapindaceae) from Michoacán, Mexico, with Notes on S. biternata
Authors: Ferrucci María Silvia , Steinmann Victor Werner
Published: August 2019

Abstract—Serjania rosalindae and Serjania crucensis (Sapindaceae-Paullinieae), new species from the municipality of La Huacana, Michoacán, Mexico, are described, illustrated, and compared with closely related species. In addition,
micromorphological features of the leaves, flowers, and pollen grains are investigated. A treatment of the endemic S. biternata from Guerrero is also included because it is a little-known taxon similar to S. rosalindae whose fruits were previously unknown. All of
these taxa share capsules that are chartaceous to almost woody and septifragal, a fruit type otherwise uncommon within Serjania. The distinctive fruit morphology of these species is discussed in relation to other species of Serjania.
Three New Species of Justicia L. (Acanthaceae) from Brazil
Authors: Araújo da Silva Fabio , Gil André dos Santos Bragança , de Souza Reis Agirlayne , Fernandes-Júnior Aluisio José , Pinto da Luz Cynthia Fernandes , Kameyama Cíntia
Published: August 2019

Abstract—Three new species of Justicia (Acanthaceae), Justicia birae, Justicia distichophylla, and Justicia mcdadeana, discovered during the preparation of a taxonomic treatment of Acanthaceae for the “Flora of
the cangas of the Serra dos Carajás, Pará, Brazil” are described. Their distribution, habitat data, conservation status, taxonomic comments, and illustrations are provided.
A New Species of Oxylobus (Asteraceae: Eupatorieae) and Updated Taxonomic Treatment of the Genus
Authors: Redonda-Martínez Rosario , Martínez Salas Esteban Manuel
Published: August 2019

Abstract—The new species Oxylobus coyulensis, currently only known from the Tehuacan-Cuicatlan Valley Biosphere Reserve, located in the states of Oaxaca and Puebla, Mexico, is described. The new taxon can be distinguished from the other species of the
genus by leaf shape, leaf trichome diversity, and cypselae surface characteristics. In addition, following a detailed micromorphological study of the species within this genus, it was found that O. juarezensis and O. subglabrus present the same leaf trichome diversity, similar
cypselae surface characteristics, and similar macromorphological characters, namely leaf shape and margins, phyllaries, and inflorescence type. As a consequence, it is concluded that O. juarezensis is synonymous with O. subglabrus, as moreover, they are distributed in the same
geographical area.
Academic Reader: An Interactive Question Answering System on Academic Literatures
Authors: Hong Yining , Wang Jialu , Jia Yuting , Zhang Weinan , Wang Xinbing
Published: August 2019

We present Academic Reader, a system which can read academic literatures and answer the relevant questions for researchers. Academic Reader leverages machine reading comprehension technique, which has been successfully applied in many fields but has not been involved in academic literature reading. An interactive platform is established to demonstrate the functions of Academic Reader. Pieces of academic literature and relevant questions are input to our system, which then outputs answers. The system can also gather users’ revised answers and perform active learning to continuously improve its performance. A case study is provided presenting the performance of our system on all papers accepted in KDD 2018, which demonstrates how our system facilitates massive academic literature reading.
Scientific Article Search System Based on Discourse Facet Representation
Authors: Kobayashi Yuta , Shindo Hiroyuki , Matsumoto Yuji
Published: August 2019

We present a browser-based scientific article search system with graphical visualization. This system is based on triples of distributed representations of articles, each triple representing a scientific discourse facet (Objective, Method, or Result) using both text and citation information. Because each facet of an article is encoded as a separate vector, the similarity between articles can be measured by considering the articles not only in their entirety but also on a facet-by-facet basis. Our system provides three search options: a similarity ranking search, a citation graph with facet-labeled edges, and a scatter plot visualization with facets as the axes.
Reinforcement Learning for Improved Low Resource Dialogue Generation
Authors: González-Garduño Ana V.
Published: August 2019

In this thesis, I focus on language independent methods of improving utterance understanding and response generation and attempt to tackle some of the issues surrounding current systems. The aim is to create a unified approach to dialogue generation inspired by developments in both goal oriented and open ended dialogue systems. The main contributions in this thesis are: 1) Introducing hybrid approaches to dialogue generation using retrieval and encoder-decoder architectures to produce fluent but precise utterances in dialogues, 2) Proposing supervised, semi-supervised and Reinforcement Learning methods for domain adaptation in goal oriented dialogue and 3) Introducing models that can adapt cross lingually.
Counterfactual Reasoning in Observational Studies
Authors: Hassanpour Negar
Published: August 2019

To identify the appropriate action to take, an intelligent agent must infer the causal effects of every possible action choices. A prominent example is precision medicine that attempts to identify which medical procedure will benefit each individual patient the most. This requires answering counterfactual questions such as: ""Would this patient have lived longer, had she received an alternative treatment?"". In my PhD, I attempt to explore ways to address the challenges associated with causal effect estimation; with a focus on devising methods that enhance performance according to the individual-based measures (as opposed to population-based measures).
Verifiable and Interpretable Reinforcement Learning through Program Synthesis
Authors: Verma Abhinav
Published: August 2019

We study the problem of generating interpretable and verifiable policies for Reinforcement Learning (RL). Unlike the popular Deep Reinforcement Learning (DRL) paradigm, in which the policy is represented by a neural network, the aim of this work is to find policies that can be represented in highlevel programming languages. Such programmatic policies have several benefits, including being more easily interpreted than neural networks, and being amenable to verification by scalable symbolic methods. The generation methods for programmatic policies also provide a mechanism for systematically using domain knowledge for guiding the policy search. The interpretability and verifiability of these policies provides the opportunity to deploy RL based solutions in safety critical environments. This thesis draws on, and extends, work from both the machine learning and formal methods communities.
Attention Guided Imitation Learning and Reinforcement Learning
Authors: Zhang Ruohan
Published: August 2019

We propose a framework that uses learned human visual attention model to guide the learning process of an imitation learning or reinforcement learning agent. We have collected high-quality human action and eye-tracking data while playing Atari games in a carefully controlled experimental setting. We have shown that incorporating a learned human gaze model into deep imitation learning yields promising results.
Learning Flexible Latent Representations via Encapsulated Variational Encoders
Authors: Bai Wenjun , Quan Changqin , Luo Zhi-Wei
Published: August 2019

Learning flexible latent representation of observed data is an important precursor for most downstream AI applications. To this end, we propose a novel form of variational encoder, i.e., encapsulated variational encoders (EVE) to exert direct control over encoded latent representations along with its learning algorithm, i.e., the EVE compatible automatic variational differentiation inference algorithm. Armed with this property, our derived EVE is capable of learning converged and diverged latent representations. Using CIFAR-10 as an example, we show that the learning of converged latent representations brings a considerable improvement on the discriminative performance of the semi-supervised EVE. Using MNIST as a demonstration, the generative modelling performance of the EVE induced variational auto-encoder (EVAE) can be largely enhanced with the help of learned diverged latent representations.
Matroid Constrained Fair Allocation Problem
Authors: Biswas Arpita , Barman Siddharth
Published: August 2019

We consider the problem of allocating a set of indivisible goods among a group of homogeneous agents under matroid constraints and additive valuations, in a fair manner. We propose a novel algorithm that computes a fair allocation for instances with additive and identical valuations, even under matroid constraints. Our result provides a computational anchor to the existential result of the fairness notion, called EF1 (envy-free up to one good) by Biswas and Barman in this setting. We further provide examples to show that the fairness notions stronger than EF1 does not always exist in this setting.
An Imperfect Algorithm for Coalition Structure Generation
Authors: Changder Narayan , Aknine Samir , Dutta Animesh
Published: August 2019

Optimal Coalition Structure Generation (CSG) is a significant research problem that remains difficult to solve. Given n agents, the ODP-IP algorithm (Michalak et al. 2016) achieves the current lowest worst-case time complexity of O(3n). We devise an Imperfect Dynamic Programming (ImDP) algorithm for CSG with runtime O(n2n). Imperfect algorithm means that there are some contrived inputs for which the algorithm fails to give the optimal result. Experimental results confirmed that ImDP algorithm performance is better for several data distribution, and for some it improves dramatically ODP-IP. For example, given 27 agents, with ImDP for agentbased uniform distribution time gain is 91% (i.e. 49 minutes).
Robust Principal Component Analysis-Based Infrared Small Target Detection
Authors: Chen Qiwei , Wu Cheng , Wang Yiming
Published: August 2019

A method based on Robust Principle Component Analysis (RPCA) technique is proposed to detect small targets in infrared images. Using the low rank characteristic of background and the sparse characteristic of target, the observed image is regarded as the sum of a low-rank background matrix and a sparse outlier matrix, and then the decomposition is solved by the RPCA. The infrared small target is extracted from the single-frame image or multi-frame sequence. In order to get more efficient algorithm, the iteration process in the augmented Lagrange multiplier method is improved. The simulation results show that the method can detect out the small target precisely and efficiently.
A Randomized, Double-Blinded, Phase II Trial of Carboplatin and Pemetrexed with or without Apatorsen (OGX-427) in Patients with Previously Untreated Stage IV Non-Squamous-Non-Small-Cell Lung Cancer: The SPRUCE Trial
Authors: Spigel David R. , Shipley Dianna L. , Waterhouse David M. , Jones Suzanne F. , Ward Patrick J. , Shih Kent C. , Hemphill Brian , McCleod Michael , Whorf Robert C. , Page Ray D. , Stilwill Joseph , Mekhail Tarek , Jacobs Cindy , Burris Howard A. , Hainsworth John D.
Published: August 2019

Background

This randomized, double-blinded, phase II trial evaluated the efficacy of carboplatin and pemetrexed plus either apatorsen, an antisense oligonucleotide targeting heat shock protein (Hsp) 27 mRNA, or placebo in patients with previously untreated metastatic nonsquamous non-small cell lung cancer (NSCLC).

Methods

Patients were randomized 1:1 to Arm A (carboplatin/pemetrexed plus apatorsen) or Arm B (carboplatin/pemetrexed plus placebo). Treatment was administered in 21-day cycles, with restaging every two cycles, until progression or intolerable toxicity. Serum Hsp27 levels were analyzed at baseline and during treatment. The primary endpoint was progression-free survival (PFS); secondary endpoints included overall survival (OS), objective response rate, and toxicity.

Results

The trial enrolled 155 patients (median age 66 years; 44% Eastern Cooperative Oncology Group performance status 0). Toxicities were similar in the 2 treatment arms; cytopenias, nausea, vomiting, and fatigue were the most frequent treatment-related adverse events. Median PFS and OS were 6.0 and 10.8 months, respectively, for Arm A, and 4.9 and 11.8 months for Arm B (differences not statistically significant). Overall response rates were 27% for Arm A and 32% for Arm B. Sixteen patients (12%) had high serum levels of Hsp27 at baseline. In this small group, patients who received apatorsen had median PFS of 10.8 months, and those who received placebo had median PFS 4.8 months.

Conclusion

The addition of apatorsen to carboplatin and pemetrexed was well tolerated but did not improve outcomes in patients with metastatic nonsquamous NSCLC cancer in the first-line setting.

Implications for Practice

This randomized, double-blinded, phase II trial evaluated the efficacy of carboplatin and pemetrexed plus either apatorsen, an antisense oligonucleotide targeting heat shock protein 27 mRNA, or placebo in patients with previously untreated metastatic nonsquamous non-small cell lung cancer (NSCLC). The addition of apatorsen to carboplatin and pemetrexed was well tolerated but did not improve outcomes in patients with metastatic nonsquamous NSCLC cancer in the first-line setting.
The influence of gradient on saturation flow rate at signalised intersections
Authors: Bruwer M , Bester C , Viljoen E
Published: August 2019

Saturation flow rate is the maximum hourly traffic volume per lane that can be accommodated through an intersection, and is used in the design and analysis of signalised intersections and traffic signal plans. The most widely applied method to estimate saturation flow rate is provided by the Highway Capacity Manual (HCM), which proposes default values obtained from USA empirical data for application in saturation flow rate calculations. This study considers the applicability of the HCM proposed base saturation flow rates, and particularly the adjustment factors for gradient on saturation flow in the South African context. The data for this research was collected by author ES Viljoen for use in her dissertation conducted in the final year of the BEng degree at Stellenbosch University. The influence of approach lane gradient on saturation flow rate was investigated for application in the South African environment. The results of this research indicate that the HCM underestimates the influence of approach gradient on saturation flow rate, a similar finding to other international research. The standard use of a base saturation flow rate of 1 900 passenger cars per hour per lane for South African conditions was also commented on. HCM methods do not take into account the influence of speed limit on saturation flow rate, which has been shown to significantly affect saturation flow rate in numerous research projects, and is also commented on in this paper for zones with a 60 km/h and 80 km/h speed limit.
Sequencing Protocols for the One Thousand Plant Transcriptomes Initiative v1
Authors: J. Carpenter Eric
Published: August 2019

The 1000 Plants (1KP) initiative explored the genetic diversity of green plants (Viridiplantae) by sequencing RNA from 1,342 samples representing 1,173 species. All of the analyses done for the 1KP capstone, and previous studies on subsets of these data, are based on a series of de novo transcriptome assemblies and related outputs that will be described in this publication. We expect that these data will also be useful to other researchers with interests in specific gene families, either across the green plant tree of life or in more focused lineages. These protocols provide additional details on the sample and sequence processing, hopefully providing insight for reproducibility and tools for other researchers working on plant transcriptomics and evolution.
Illumina GAII Library Construction and Sequencing for RNA Seq v1
Authors: J. Carpenter Eric , Matasci Naim , Wu Shuangxiu , Sun Jing , Yu Jun , Rocha Jimenez Vieira Fabio , Bowler Chris , G. Dorrell Richard , Gitzendanner Matt , Li Ling , Du Wensi , Ullrich Kristian , S. Barker Michael , H. Leebens-Mack James , Ka-Shu Wong Gane
Published: August 2019

Illumina GAII Library Construction and Sequencing for RNA Seq
Neuropathy Phentoyping Protocols - Dosages of Analgesics for Rats and Mice v1
Authors: Feldman Eva
Published: August 2019

Summary: Phenotyping of Rodents for the Presence of Diabetic Neuropathy In man, the development of diabetic neuropathy is dependent on both the degree of glycemic control and the duration of diabetes. Diabetic neuropathy is a progressive disorder, with signs and symptoms that parallel the loss of nerve fibers over time. Consequently, assessments of neuropathy in mice are not performed at one time point, but are characterized at multiple time points during a 6 month period of diabetes. The degree of diabetes is evaluated in 2 ways: tail blood glucose measured following a 6 hour fast and glycated hemoglobin levels. The initial degree of neuropathy is screened using the methods discussed below. Detailed measures of neuropathy are employed when the initial screening instruments indicate a profound or unique phenotypic difference. This document contains protocols used by the DiaComp staff to examine and measure diabetic neuropathy at the whole animal, tissue and cellular levels. Diabetic Complication:
Neuropathy Phentoyping Protocols - Immunohistochemistry for Tissue Sections v1
Authors: Feldman Eva
Published: August 2019

Summary: Phenotyping of Rodents for the Presence of Diabetic Neuropathy In man, the development of diabetic neuropathy is dependent on both the degree of glycemic control and the duration of diabetes. Diabetic neuropathy is a progressive disorder, with signs and symptoms that parallel the loss of nerve fibers over time. Consequently, assessments of neuropathy in mice are not performed at one time point, but are characterized at multiple time points during a 6 month period of diabetes. The degree of diabetes is evaluated in 2 ways: tail blood glucose measured following a 6 hour fast and glycated hemoglobin levels. The initial degree of neuropathy is screened using the methods discussed below. Detailed measures of neuropathy are employed when the initial screening instruments indicate a profound or unique phenotypic difference. This document contains protocols used by the DiaComp staff to examine and measure diabetic neuropathy at the whole animal, tissue and cellular levels. Diabetic Complication:
Neuropathy Phentoyping Protocols - Transmission Electron Microscopy v1
Authors: Feldman Eva
Published: August 2019

Summary: Phenotyping of Rodents for the Presence of Diabetic Neuropathy In man, the development of diabetic neuropathy is dependent on both the degree of glycemic control and the duration of diabetes. Diabetic neuropathy is a progressive disorder, with signs and symptoms that parallel the loss of nerve fibers over time. Consequently, assessments of neuropathy in mice are not performed at one time point, but are characterized at multiple time points during a 6 month period of diabetes. The degree of diabetes is evaluated in 2 ways: tail blood glucose measured following a 6 hour fast and glycated hemoglobin levels. The initial degree of neuropathy is screened using the methods discussed below. Detailed measures of neuropathy are employed when the initial screening instruments indicate a profound or unique phenotypic difference. This document contains protocols used by the DiaComp staff to examine and measure diabetic neuropathy at the whole animal, tissue and cellular levels. Diabetic Complication:
Generating chemically competent (E. coli) cells v2
Authors: Yin Phua Su , Chi Khin Nay , Tee Estee , R Ganguly Diep , Xun Chan Kai , Albrecht-Borth Veronica , J Pogson Barry
Published: August 2019

Protocol for generating chemically compotent (ie. for heat shock transformation) E. coli cells for transformation (e.g. heterologous protein expression, cloning).
Cytotoxicity Assay - Calcein AM v1
Authors: Abdo Luiza , Chicaybam Leonardo , Bonamino Martin
Published: August 2019

This protocol is used to evaluate the cytotoxic capacity of effector cells (T cells, NK cells) when co-cultured with target cells (tumor cells) in different ratios. They basically consist of staining the target cells with calcein-acetoxymethyl fluorescent dye (calcein-AM) and measuring the fluorescence released in the culture medium (dead cells) a few hours after coculturing with effector cells. Reference protocol described by Neri et al. (10.1128/CDLI.8.6.1131-1135.2001)
Determination of effects of amniotic membrane homogenate on the growth of the uropathogenic Escherichia coli, S. aureus and S. marcescens strainsDetermination of effects of amniotic membrane homogenate on the growth of the uropathogenic Escherichia coli, S v1
Authors: Sket Tina , Zeleznik Ramuta Taja , Starčič Erjavec Marjanca , Erdani Kreft Mateja
Published: August 2019

Purpose: Due to the emergence and spread of bacterial strains resistant to antibiotics, the development of new antimicrobials is imperative. The antimicrobial effect of the amniotic membrane (AM), the innermost part of placenta, has been explored to a limited extent so far. Materials and Methods:We collected 12 biological samples of AM homogenates, which we used for testing of AM’s antimicrobial effect on 4 pathogens, including the clinical strain of uropathogenic Escherichia coli (UPEC), the wild-type strain of Staphylococcus aureus, and the wild-type strain and a clinical strain of Serratia marcescens. To quantify and better understand the antibacterial effect of AM, we monitored the effect of AM homogenate on bacterial growth using plate count method and agar diffusion method. Additionally, minimal inhibitory concentrations (MICs) for AM homogenate dilutions were determined and S. marcescens growth in AM homogenate alone was evaluated. Results: Our results clearly demonstrated that AM homogenate had a bacteriostatic effect on studied UPEC and S. aureus. Interestingly, when used in lower concentrations, the AM homogenate had a bactericidal effect on both strains. In contrast, S. marcescenswas completely resistant to the growth-inhibitory substances of AM homogenate. In fact, its growth was slightly accelerated in liquid culture medium in the presence of AM homogenate and the strain was able to grow in undiluted, 2-fold and 4-fold diluted AM homogenate as well. Conclusion: Obtained results illustrated that AM homogenate could be a candidate for treatments and prevention of UPEC and S. aureus infections, but not that of S. marcescens, whose growth is enhanced by AM homogenate. Moreover, the established liquid culture medium assay can be used as a time- and cost-effective method for a personalized evaluation of drug effect on the growth of chosen bacterial strains with parallel testing of resistance or susceptibility to multiple drugs. Importantly, the susceptibility of bacteria to AM homogenate in solid and liquid culture media is encouraging for its use in biomedical applications.
Proteomics of transcription factors: identification of pool of HL-60 cell line-specific regulatory proteins
Authors: Novikova S.E. , Vakhrushev I.V. , Tsvetkova A.V. , Shushkova N.A. , Farafonova T.E. , Yarygin K.N. , Zgoda V.G.
Published: August 2019

HL-60 promyelocytic cells are a widely used as a model for studying induced granulocytic differentiation. Investigation of proteins of the nuclear fraction, particularly transcription factors, is necessary for a better understanding of molecular mechanisms of cell maturation. Mass spectrometry is a powerful tool for analyzing a proteome due to its high sensitivity, specificity and performance. In this paper, using the selected reaction monitoring (SRM) method, we have assessed the levels of RBPJ, STAT1, CEBPB, CASP3, VAV1, PRKDC, PARP1 and UBC9 nuclear proteins isolated using hypertonic buffer, detergents (sodium dodecyl sulfate (SDS), sodium deoxycholate (DOC) and fissionable detergent ProteaseMAX™) and using centrifugation in a sucrose density gradient. The minimum and maximum protein content was 1.13±0.28 and 14.34±1.63 fmol/mkg of total protein for the transcription factor RBPJ and ubiquitin-protein ligase type I UBC9, respectively. According to the results of shotgun mass spectrometric analysis of nuclear fractions, 2356 proteins were identified, of which 106 proteins were annotated as transcription factors. 37 transcription factors were uniquely identified in the fraction obtained by centrifugation in a sucrose density gradient, while only 9 and 8 transcription factors were uniquely identified in the nuclear fractions obtained using hypertonic buffer and detergents, respectively. The transcription factors identified in the HL-60 cell line represent regulatory molecules; their directed profiling under the influence of differentiation inducers, will shed light on the mechanism of granulocyte maturation.
A biosensor study of protein interaction with the 20S proteasome core particle
Authors: Buneeva O.A. , Gnedenko O.V. , Medvedeva M.V. , Zgoda V.G. , Ivanov A.S. , Medvedev A.E.
Published: August 2019

It becomes increasingly clear that ubiquitination of cellular proteins is not an indispensable prerequisite of their degradation in proteasomes. There are a number of proteins to be eliminated which are not pre-ubiquitinated for their recognition by regulatory subcomplex of 26S proteasome, but which directly interact with the 20S proteasome core particle (20S proteasome). The obligatory precondition for such interaction consists in existence of disordered (hydrophobic) fragments in the target protein. In this study we have investigated the interaction of a number of multifunctional (moonlighting) proteins (glyceraldehyde-3-phosphate dehydrogenase (GAPDH), aldolase, pyruvate kinase) and neurodegeneration-related proteins (a-synuclein, myelin basic protein) with 20S proteasome immobilized on the SPR-biosensor chip and stabilized by means of a bifunctional agent dimethyl pimelimidate (in order to prevent possible dissociation of this subcomplex). Only two of all investigated proteins (aldolase and pyruvate kinase) interacted with the immobilized 20S proteasome (Kd of 8.17´10-7 M and 5.56´10-7 M, respectively). In addition to earlier detected GAPDH ubiquitination, mass spectrometric analysis of the studied proteins revealed the presence of the ubiquitin signature (Lys-e-Gly-Gly) only in aldolase. Oxidation of aldolase and pyruvate kinase, which promotes elimination of proteins via their direct interaction with 20S proteasome, caused a 2-3-fold decrease in their Kd values as comparison with this parameter obtained for the intact proteins. The results of this study provide further evidence for direct interaction of both ubiquitinated proteins (aldolase), and non-ubiquitinated proteins (pyruvate kinase) with the 20S proteasome core particle (20S proteasome). The effectiveness of this interaction is basically equal for the ubiquitinated proteins and non-ubiquitinated proteins.
Effect of the sulfur-containing compounds on the quinoid process of adrenaline autoxidation; potential neuroprotectors
Authors: Sirota T.V.
Published: August 2019

The superoxide-generating reaction of adrenaline autoxidation in an alkaline medium, used in vitro to identify the antioxidant properties of various compounds, simulates the complex multistep process of quinoid oxidation of catecholamines (CA) in the body. Sulfur-containing cysteine (Cys) and reduced glutathione (GSH), as well as oxidized glutathione (GSSG), have been shown to inhibit this process. The studied substances were considered as inhibitors of quinoid oxidation and are evaluated as antioxidants. The IC50 values for Cys and GSH were close to 7.5 mM. Inhibition by GSSG was weaker; represented approximately 50-70% of Cys and GSH. Other sulfur-containing compounds that differ in chemical structure, the amino acids taurine and methionine were ineffective. The interest in this model and the search for effective compounds acting on this reaction is associated with one of the mechanisms of the etiopathogenesis of Parkinson's disease (PD) discussed in the literature, which occurs when the biochemical transformations of dopamine CA and its quinoid oxidation process are violated. Cys, GSH and GSSG in the model system inhibit quinoid oxidation of adrenaline, as a result of which the formation of superoxide (O2 ·-) is also inhibited. Experiments with the superoxide-generating enzymatic reaction xanthine xanthioxidase, the chemistry of which is different and not related to formation of quinoid metabolites, showed that the studied substances did not inhibit O2 ·- formation in this model. Thus, it was established that the biologically active sulfur-containing compounds Cys, GSH and GSSG are specific inhibitors of quinoid oxidation of CA, and are likely to be able to play the role of a neuroprotector. It is proposed to use these compounds in the treatment and prevention of PD by activating their biosynthesis in the body.
Elevated first trimester C-reactive protein as a predictor of gestational diabetes
Authors: Parihar Sanjay , Singh Rajesh
Published: August 2019

Background: The incidence of type 2 diabetes is increasing at an alarming rate, particularly among young women. GDM is a unique prediabetes state that shares common risk factors with type 2 diabetes, and similar alterations in carbohydrate metabolism. Objectives of this study the elevation of C-reactive protein in the first trimester of pregnancy as a predictor of gestational diabetes.Methods: This hospital-based study comprised of patients (Primigravida) visiting the obstetric OPD or admitted in Obstetric wards. Detailed history and clinical examination of the patient was recorded on a Proforma. Blood samples of patients were taken for: (i) C-reactive protein in first trimester of pregnancy; and (ii) Blood sugar (fasting & post-prandial) during their first antenatal visit and patients were followed up in subsequent visits in second and third trimester for development of gestational diabetes.Results: There were seven women who developed gestational diabetes and had elevated first trimester C- reactive protein levels as compared to other group in which only two women developed gestational diabetes mellitus but did not have elevated C-reactive protein in their first trimester. However, there were two women, who had elevated C-reactive protein, but did not subsequently develop gestational diabetes mellitus and women with C-reactive protein in normal range who did not develop gestational diabetes mellitus were 56.Conclusion: An association between first trimester inflammation marked by increased CRP levels, and subsequent risk of development of GDM has been identified.
La elaboración de proyectos de inversión como estudio de casos de estudio para lograr aprendizajes significativos
Authors: Arciniegas Calderón Ana Isabel
Published: August 2019

Se presenta una propuesta para lograr aprendizajes significativos mediante el estudio de casos de formulación de proyectos de inversión. Se expone el análisis, crítico e integral, del estudio de un caso práctico: la conveniencia de mejorar o diversificar el portafolio de productos de una empresa ya existente. Se explican los principales términos y conceptos. Se describe el proceso metodológico usado y se detalla la secuencia de actividades del proceso para elaborar el proyecto de inversión tomado como caso de estudio. Se presentan resultados obtenidos al final del trabajo tanto dentro como fuera del aula. Por último, se concluye que los estudiantes sí logran aprendizajes significativos mediante el estudio de casos.
Investigación, práctica curricular y virtualidad: experiencias en Venezuela
Authors: Schmidt H. Ludwig
Published: August 2019

Con respecto a la triada investigación, práctica curricular y virtualidad, la educación virtual ha evidenciado un emprendimiento más efectivo, al superar escollos de tiempo y espacio mediante innovadores métodos, técnicas y recursos que hacen más efectivo y flexible el proceso de enseñanza-aprendizaje. Esta nueva modalidad educativa da validez así a los principios de educación para todos, aprender a aprender, la enseñanza-aprendizaje personalizada, la educación para toda la vida, es decir, la educación permanente o continua. Además, permite una relación particular con el desarrollo de un pensamiento crítico latinoamericano, cuya preocupación por el conocimiento de los límites de la sociedad actual y las posibilidades de configurar un orden más humano y justo enriquece lo social y la convivencia armónica.
Aprendizaje emocional y social: enseñar y aportar a la formación integral
Authors: Ferreyra Horacio Ademar
Published: August 2019

El artículo ofrece algunas reflexiones sobre las posibilidades que el desarrollo del aprendizaje emocional y social ofrece en los distintos niveles educativos y cuáles son sus aportes a la construcción de una propuesta curricular, pedagógica y didáctica orientada a la formación integral de los y las estudiantes. El referente es una política educativa del Ministerio de Educación de la Provincia de Córdoba (Argentina). En primer lugar, se presenta el marco general de dicha política y sus objetivos y se explicitan algunos conceptos claves. Luego, se presenta la articulación entre la propuesta de desarrollo de capacidades fundamentales y el aprendizaje emocional y social. Finalmente, se hacen algunas precisiones curriculares, pedagógicas y didácticas para el desarrollo del aprendizaje social en las escuelas y en las aulas y algunas orientaciones particulares para el trabajo en los distintos niveles del sistema educativo.
Kripto Para Birimlerinin Piyasa Değerlerindeki Değişimlerin Analizi
Authors: Gültekin Yaşar , Özdemir Fevzi Serkan , Varıcı İdris
Published: August 2019

Kripto para birimleri; paranın piyasaya
sürülmesi ve kullanıcıları arasındaki transfer işlemlerinde kriptografiyi
kullanan elektronik para birimleridir. 2009 yılında ilk kez Satoshi Nakamoto
tarafından teknik altyapısı kurularak piyasadaki yerini alan Bitcoin’in
ardından şifreleme algoritmaları, işlem kanıtları ve madencilik faaliyetine
konu olmaları bakımından farklı özelliklere sahip yüzlerce kripto para birimi
ortaya çıkmıştır. Bu para birimleri, tarihsel süreçte bir yatırım aracı olarak
da kullanılmaya başlanmıştır. Günümüzde, bu para birimleri ile işlem yapan
piyasalar oluşmuş ve 2017 yılı başı itibariyle toplamda yaklaşık 17,7 milyar
dolarlık piyasa değerine ulaşılmıştır. 2016 yılı başına kadar bu piyasa
değerinin %90’lık kısmından fazlasına sahip olan Bitcoin’in piyasa payı gün
geçtikçe azalmış ve bu da piyasayı oluşturan diğer para birimlerinin
incelenmesini gerekli hale getirmiştir.                Bu
çalışma 01.01.2017 tarihinde piyasada bulunan ve piyasa değeri en yüksek on
kripto para biriminin günlük fiyat değişimleri ile piyasa değeri bakımından ilk
yüzü oluşturan kripto para birimlerinin fiyat değişimleri arasında korelasyon
olup olmadığını belirlemek amacıyla yapılmıştır. Çalışma sonucunda, piyasada
bulunan kripto para birimlerinin değer değişimi açısından toplu mu yoksa ayrık
mı hareket ettiği tespit edilecek ve yorumlanacaktır. Çalışmaya konu olan para
birimlerinin fazlalığı nedeniyle veriler 2016 takvim yılı için toplanmış ve
analiz edilmiştir.                  Anahtar Kelimeler: Kripto Para, Yatırım,
Analiz.

                JEL Sınıflandırması: G11.
Çevresel Kuznets Eğrisi Hipotezi’nin Ampirik Analizi: Türkiye Ekonomisi Örneği
Authors: Çetin Murat , Saygın Selin
Published: August 2019

Bu
çalışmasının temel amacı, ekonomik büyüme ve çevre kirliliği arasındaki
ilişkiyi ters-U şeklinde açıklayan Çevresel Kuznets Eğrisi (ÇKE) hipotezinin
geçerliliğini Türkiye ekonomisinde 1960-2014 dönemi itibariyle araştırmaktır.
Bu amaçla karbon emisyonu, kişi başına reel gelir, kişi başına reel gelirin
karesi, enerji tüketimi ve ticari dışa açıklık değişkenleri kullanılarak 3
farklı regresyon modeli oluşturulmuştur. Çalışmada değişkenlerin durağanlık
derecelerinin tespiti için ADF, PP ve KPSS birim kök testleri kullanılmıştır.
Birim kök test sonuçları, değişkenler arasındaki uzun dönem ilişkisinin tespiti
için ARDL sınır testinin kullanılmasına izin vermektedir. Bu nedenle çalışmada
değişkenler arasındaki eşbütünleşme ilişkisinin incelenmesinde ARDL sınır testi
kullanılmıştır. Son aşamada ise ARDL modeli çerçevesinde değişkenlerin uzun ve
kısa dönem katsayıları tahmin edilmiştir. Sonuçlar, uzun dönemde üç modelde de
ÇKE hipotezinin Türkiye ekonomisi için geçerliliğini desteklemiştir. Sonuçlar
aynı zamanda Türkiye ekonomisi için önemli politika önerileri sunmaktadır.Anahtar Kelimeler: Karbon Emisyonu, Ekonomik Büyüme, Çevresel Kuznets Eğrisi
Hipotezi, ARDL Sınır Testi, Türkiye.

JEL Sınıflandırması: O44, O47, C22, Q56.
Azerbaycan Ekonomisinin Hollanda Hastalığı Açısından Değerlendirilmesi
Authors: Şanlısoy Selim , Ekinci Ramazan
Published: August 2019

Bir ülkenin doğal
kaynak zenginliğine sahip olması durumunda hükümetler etkin olarak
yönetebileceklerinden çok daha fazla gelir elde etmektedir. Elde edilen gelirin
etkin bir şekilde kullanılamaması durumunda bu ülkelerin büyüme performansları
doğal kaynağa sahip olmayan ülkelerin bile gerisinde kalabilmekte bir başka
deyişle ülkeler doğal kaynaklardan bekledikleri faydadan çok, zarar
görebilmektedirler. Bu durum literatürde olgunun ilk kez Hollanda için
kullanılmasına bağlı olarak Hollanda Hastalığı olarak adlandırılmaktadır.
Bilindiği üzere Azerbaycan zengin doğal kaynaklara sahiptir. Doğal kaynakların
hem toplam ihracat içerisindeki payı hem de GSYİH içerisindeki payı yüksektir.
Bu durum Azerbaycan’ın Hollanda Hastalığı ile karşı karşıya olma riskini artırmaktadır.
Bu çalışmanın temel amacı Azerbaycan ekonomisinde Hollanda Hastalığı’nın
varlığının araştırılmasıdır. Bu amaç doğrultusunda Doğrusal Olmayan Gecikmesi
Dağıtılmış Oto Regresif Model (NARDL) kullanılmıştır. Uluslararası petrol
fiyatlarındaki pozitif bir şokun uzun dönemde reel gayrisafi yurtiçi hasılayı
artırdığı; buna karşılık uluslararası petrol fiyatlarındaki negatif bir şokun
pozitif şoka göre daha düşük bir etkiyle uzun dönemde büyümeyi azalttığı
bulgusuna ulaşılmıştır. Dolayısıyla incelenen dönem açısından Azerbaycan
ekonomisinde Hollanda Hastalığı’nın ortaya çıkmadığı ifade edilebilir.

Anahtar Kelimeler: Azerbaycan, Hollanda Hastalığı, Ham Petrol Fiyatları,
Reel Döviz Kuru

JEL Sınıflandırması: F41, C32, Q43
Yeni Medya ve Dijital Gözetim: Türkiye’deki Sosyal Medya Kullanıcıları Üzerine Bir Araştırma
Authors: Kalaman Sefer
Published: August 2019

Yeni
iletişim teknolojileri ile birlikte insan hayatı bugüne dek hiç olmadığı kadar
çok ve yine hiç olmadığı kadar farklı şekillerde gözetlenmektedir. Bu gözetimin
kuşkusuz en fazla yapıldığı mecra ise yeni medya ve yeni medyanın en önemli
ortamı olan sosyal paylaşım ağlarıdır. Bu noktadan hareketle yapılan çalışmada,
Türkiye’de yaşayan insanların yeni medyada bilgilerini ne oranda
paylaştıklarını ve yeni medya aracılığıyla gözetlendiklerin farkında olup
olmadıklarını tespit etmek amaçlanmıştır. Çalışmada verileri elde etmek için
bir saha araştırması yapılmış ve araştırmada nicel araştırma yöntemlerinden
biri olan anket tekniği kullanılmıştır. Araştırmanın evrenini, Türkiye’de
yaşayan 15 yaş ve üzerindeki yaklaşık 35 milyon Facebook kullanıcısı
oluşturmaktadır. Örneklemi ise, Türkiye’de yaşayan, 15 yaş ve üzerindeki 5000
Facebook kullanıcısı temsil etmektedir. Çalışmada elde edilen bulgulara göre,
katılımcıların Facebook’ta bilgilerini paylaşma düzeyleri yüksek olmaktadır.
Bunun yanında katılımcıların Facebook aracılığıyla ticari şirketler ve kamu
kurumları tarafından gözetlendiklerinin farkında olma düzeyleri ise düşük olmaktadır.
Çalışmada ayrıca katılımcıların gözetim farkındalıkları, cinsiyet, yaş, eğitim,
yaşanılan yer, çalışma durumu ve bölge grupları temelinde incelenmiş ve anlamlı
farklılıklara ulaşılmıştır.Anahtar Kelimeler: Yeni Medya, Gözetim, Dijitalleşme, FacebookJEL Sınıflandırması: Y90, Z00, Z13
Paternalist Liderlik Algısının Çalışan Sesliliğine Etkisi: Gıda Sektörü Çalışanları Üzerine Bir Araştırma
Authors: Özyılmaz Bilge , Oral Ataç Lale
Published: August 2019

Bu
araştırmanın amacı, paternalist liderlik algısının çalışan sesliliği üzerindeki
etkisini ortaya koymaktır. Bu amaçla tamamı gıda sektöründe faaliyet gösteren
işletmelerde çalışan 123 katılımcıdan anket tekniği ile veri toplanmıştır.
Kullanılan anket formu, Paternalist Liderlik Ölçeği ve Çalışan Sesliliği Ölçeği
ile birlikte örneklemin demografik özelliklerini ölçmek üzere hazırlanmış
sorulardan oluşmaktadır. Analiz sonuçlarına göre, paternalist liderlik
ölçeğinin tüm alt boyutları (iş yerinde aile ortamı, iş dışı yaşama katılma,
sadakat ve itaat beklentisi) ile çalışan sesliliği arasında pozitif yönlü
anlamlı korelasyon bulunmaktadır. Ayrıca paternalist liderliğin iş dışı yaşama
katılma alt boyutu, çalışan sesliliği üzerinde pozitif yönlü anlamlı etkiye sahiptir.
Anahtar Kelimeler: Paternalist liderlik, çalışan sesliliği,
gıda sektörü.

JEL Sınıflandırması: M10, M54
Örgüt Kültürü ve Bağlamsal Performans Arasındaki İlişkide Temel Motivasyon Kaynaklarının Biçimleyici Rolü
Authors: Eryılmaz İnan , Altın Gülova Asena
Published: August 2019

Bu çalışmanın amacı havacılık sektöründe faaliyet gösteren örgütlerde hâkim olun örgüt kültürü tipini (klan, adhokrasi, hiyerarşi, pazar) belirlemek ve örgüt kültürü tipleri ile çalışanların bağlamsal performans düzeyleri arasındaki ilişkiyi incelemektir. Ayrıca çalışmada, bireylerin temel motivasyon kaynaklarının (başarı ihtiyacı, bağlanma ihtiyacı, güç ihtiyacı) varsayılan ilişkide düzenleyici rolünü sınanmaktadır. Bu amaç doğrultusunda İstanbul, Ankara, İzmir, Malatya ve Isparta’da faaliyet gösteren kamu ve özel havacılık örgütlerinden 265 katılımcıya araştırma ölçekleri ve demografik değişkenleri içeren anket uygulanmıştır. Araştırma bulgularına göre katılımcılar örgütlerinde en fazla hiyerarşi ve klan kültürü algılamaktadır. Korelasyon analizi neticesinde en fazla klan kültürü algısı ile bağlamsal performansın ilişkili olduğu bulgulanmıştır. Katılımcıların güç ihtiyacının hiyerarşi ve klan kültürleri ile bağlamsal performans arasındaki ilişkileri, başarı ihtiyacının ise hiyerarşi kültürü ve bağlamsal performans arasındaki ilişkiyi biçimlediği tespit edilmiştir.
The Test - For OJS 3
Authors: Bloggs Jo
Published: August 2019

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Tecnologias educativas gerontogeriátricas nas diferentes temáticas de saúde: uma revisão integrativa
Authors: Correa Pereira Embert Luan , Zanin Sanguino Gabriel , Sales Ronchi Tamiris , Fernanda Previato Giselle , Estevam Jaques André , Denardi Antoniassi Baldissera Vanessa
Published: August 2019

Objetivo: Analisar as tecnologias educativas em saúde desenvolvidas para a população idosa brasileira nas diferentes temáticas. Método: Revisão integrativa de literatura realizada nas bases de dados Lilacs, BdEnf, MEDLINE, Web of Science e Scopus, com os descritores: tecnologia educacional e saúde do idoso. A revisão foi norteada pela seguinte questão: “Quais tecnologias educativas em saúde têm sido utilizadas para a população idosa brasileira, nas diferentes temáticas?” Resultados: Foram selecionados sete artigos, e emergiram três categorias temáticas: 1) Tecnologias educacionais utilizadas na educação em saúde com idosos brasileiros; 2) Temáticas utilizadas nas tecnologias educacionais na educação em saúde com idosos brasileiros; 3) Impactos das tecnologias educacionais na educação em saúde com idosos brasileiros. Conclusão: Observou-se que a temática é minimamente abordada, demonstrado pelo baixo número de artigos encontrados. É importante que as tecnologias educativas sejam amplamente discutidas, visto que esse instrumento facilita a interação entre profissionais e usuários dos serviços de saúde.
Avaliação da qualidade de vida no trabalho de docentes universitários
Authors: Araújo Açucena Leal de , Fé Érica De Moura , Araújo Dinah Alencar de Melo , Oliveira Ellaine Santana de , Moura Ionara Holanda de , Silva Ana Roberta Vilarouca da
Published: August 2019

Objetivo: Analisar a qualidade de vida no trabalho de docentes de uma universidade pública. Métodos: Trata-se de um estudo de caráter descritivo e transversal, de abordagem quantitativa. Realizado com n=102 docentes de uma instituição de ensino superior pública, localizada no Centro-Sul piauiense. Fez-se uso do instrumento criado por Walton, validado e adaptado à realidade do trabalho docente. Esse instrumento compreende oito dimensões referentes à qualidade de vida no trabalho, mensurando o nível de satisfação laboral com questões do tipo Likert. Os dados foram organizados por meio do software Excel 8.0 e processados no programa estatístico IBM Statistical Package for the Social Sciences. Resultados: Foi observado que, das oito dimensões analisadas referentes à qualidade de vida no trabalho, três (Compensação Justa e Adequada; Oportunidade de Crescimento e Segurança; e Trabalho e Espaço Total de Vida) apresentaram-se com escores de insatisfação por parte dos docentes; enquanto, nas demais, observaram-se escores de indiferença. Conclusão: Espera-se que os resultados levantados neste estudo contribuam para a reflexão, além de nortear ações que visem à manutenção, prevenção e promoção de aspectos pertinentes à qualidade de vida no trabalho docente, colaborando com a promoção de políticas institucionais que valorizem a qualidade do trabalho desses profissionais.
Overview of Foodborne Disease Outbreaks in Brazil from 2000 to 2018
Authors: Finger Jessica A.F.F. , Baroni Wilma S.G.V. , Maffei Daniele F. , Bastos Deborah H.M. , Pinto Uelinton M.
Published: August 2019

This study aimed to assess the foodborne diseases (FBD) outbreaks reported in Brazil between 2000 and 2018, based on data from the Brazilian Ministry of Health (official data) and from the scientific literature. According to official data, 13,163 FBD outbreaks were reported in the country during this period, involving 247,570 cases and 195 deaths. The largest prevalence of FBD outbreaks was observed in the Southeast region of Brazil (45.6%). In most outbreaks it was not possible to determine the food implicated (45.9%) but among those identified, water was the most frequently associated (12.0%). The etiological agent was not identified in most outbreaks (38.0%), while Salmonella (14.4%) was the most frequently reported, among those identified. Homes were the main site of FBD occurrence (12.5%). Regarding data obtained from the scientific literature, 57 articles dealing with FBD in the country throughout the same period were selected and analyzed. Based on these articles, mixed foods were the most prevalent in the outbreaks (31.6%), Salmonella spp. was the pathogen most frequently reported (22.8%) and homes were also the main site of FBD occurrence (45.6%). Despite under-notification, the records of FBD outbreaks that have occurred in Brazil in the past recent years show alarming data, requiring attention from health authorities. The notification of outbreaks is essential to facilitate public health actions.