bluuebunny/crossref_metadata_2025 huggingface dataset:
Regards croisés: Signifiances du corps et déconstruction identitaire du pouvoir dans La Vie et demie de Sony Labou Tansi
Authors: Aïdara Aminata
Published: November 2020

Le présent article met en exergue la déconstruction de l'ordre sociopolitique préétabli par le pouvoir en postcolonie, à travers l'écriture de Sony Labou Tansi. Nous montrons comment, devant la distorsion des codes sociaux imposée par
le pouvoir, l'écrivain de 'la honte' met en place un dispositif discursif, dans lequel le corps humain, à travers moult duplications, révèle le caractère débile et inique de la pratique dictatoriale en postcolonie. Si Achille Mbembe met en exergue
l'euphorie de la domination du 'commandement', nous considérons que dans l'univers de La Vie et demie, le renversement du sérieux découle du rapport que les dirigeants initient avec la réalité corporelle, dans ses fonctions les plus triviales, à travers
'l'obsession des orifices'. Cette permutation permet à la plèbe, dont le porte-drapeau reste le personnage de Martial, de se rire du pouvoir à travers des sobriquets et des railleries de toutes sortes. L'article souligne l'éloquence du corps humain dans la pratique
discursive de Sony Labou Tansi : le corps déchiré, mutilé, nauséabond, s'exprime aisément et met sa puissance narrative au service du récit. Ce corps sanguinolent, symbole de la déchirure sociale se défend, déstabilise le pouvoir
et prend en charge toutes les revendications de la 'cible'.
A critical analysis of family law mediation in England and Wales
Authors:   , Duck Chloe Smith
Published: November 2020

The focus for this thesis for the LLM by Research is Family Law Mediation in England and Wales. The research is looking at the system both as it stands currently as well as past changes made by the government. It starts by looking at where mediation stands within alternative dispute resolution and what the history of alternative dispute resolution entails. It then moves on to look at the place of mediation in the family law system. It is mainly looking at four major parts the first one being the introduction of The Family Law Act in 1996 and what impact this had on the stance of mediation. The second part is looking at the introduction of Mediation Information and Assessment Meetings and how successful they were at meeting increasing the mediation intake. Thirdly the research looks at the introduction of the Legal Aid, Sentencing and Punishment of Offenders Act 2012 and how this changed the legal aid available for family law and what this did for mediation. Finally the research also looks at what stance children have in the mediation process and whether mediation is a beneficial process for them. Throughout the thesis is critique and analysis of these aspects of mediation concluding with whether or not the current system meets the aims the government have for alternative dispute resolution and what the future of mediation holds.
LES DÉFIS DE L’ENGAGEMENT PARENTAL EN MILIEU SCOLAIRE CHEZ LES PARENTS D’ENFANTS AUTISTES : UNE ÉTUDE QUALITATIVE
Authors: Boucher1 Catherine , des Rivières-Pigeon Catherine
Published: November 2020

L’engagement des parents dans le milieu scolaire est encouragé et valorisé, mais peu d’écrits se sont intéressés à ce sujet en contexte d’autisme. L’analyse qualitative des tâches des pères et des mères, en lien avec la scolarisation de leur enfant présentant un TSA, a permis de mieux comprendre les tâches effectuées à quatre niveaux : celles réalisées directement auprès de l’enfant, auprès du personnel scolaire, de la commission scolaire et des partenaires externes au milieu scolaire. La mise en lumière de la dimension émotionnelle de ces tâches a permis de mieux cerner l’intensité et la lourdeur de celles-ci.
HANDICAP MOTEUR ET CAPACITÉS DE RÉSILIENCE CHEZ L’ADULTE CAMEROUNAIS : ENJEUX DES REPRÉSENTATIONS CULTURELLES
Authors: Tchokote1 Emilie Clarisse , Tsala Tsala Jacques-Philippe , Scelles Régine
Published: November 2020

L’objet de cet article est de saisir les enjeux des représentations culturelles sur les capacités de résilience des personnes en situation de handicap moteur acquis à l’âge adulte. À travers la méthode clinique de recherche et les entretiens semi-directifs auprès de trois participants, il ressort que la dynamique des enjeux de la culture peut entraver ou faciliter de manière simultanée les capacités de résilience des personnes. D’où la nécessité d’une prise en charge psychologique et une résilience assistée afin d’activer les compétences existantes malgré la fragilité apparente.
LES TROUBLES DE L’ATTACHEMENT : UN MODÈLE INTÉGRATIF DES TRAJECTOIRES DÉVELOPPEMENTALES1
Authors: Sztajerowska2 Karolina , Schmiedel Sabrina , Deneault Audrey-Ann
Published: November 2020

Le modèle de l’Attachement en situation de carence de soins extrême (ASCSE) est un modèle heuristique qui suggère une trajectoire du développement du Trouble réactionnel de l’attachement (TRA) et du Trouble de l’engagement social désinhibé (TESD). L’ASCSE est ancré dans la recherche empirique sur le TRA et le TESD et basé sur la théorie de l’attachement de Bowlby (1969/1982). Il inclut les trajectoires distinctes du TRA et du TESD, qui sont présentés comme des troubles découlant d’une perturbation du système d’attachement, et une trajectoire normative. En tant que modèle intégratif, il offre un cadre à partir duquel plusieurs questions de recherche et pistes d’interventions peuvent être dérivées.
Teologia pública: incidência e desafios | Public theology: incidence and challenges
Authors: Matiello Suzana Terezinha
Published: November 2020

Resenha de: SINNER, Rudolf von. Teologia pública num Estado laico: ensaios e análises. Vol. 7. Sinodal: São Leopoldo, 2018. 248p. ISBN 978.85.8194134-9.
Diálogo inferfé e hermenêutica feminista latino-americana: possíveis caminhos | Interfaith Dialogue and Latin-American feminist hermeneutics: possible paths
Authors: Tostes Angelica
Published: November 2020

A teologia feminista latino-americana está entrelaçada com a sobrevivência e a espiritualidade diárias das mulheres, repensando assim os conceitos tradicionais de corpos subalternos. É a experiência das mulheres como uma direção para desafiar as noções de revelação e dogma. O diálogo inter-religioso tem sido construído com as lentes ocidentalizantes do Paradigma das Religiões Mundiais que fixam apenas uma noção do que é Religião. Este artigo tem como objetivo desafiar esses conceitos, tecendo hermenêuticas latino-americanas do diálogo inter-religioso, nesse caso, com as mãos de mulheres feministas. Como podemos entender a hermenêutica do diálogo inter-religioso das mulheres latino-americanas? Dialogaremos com o tema a partir do conceito de diálogo interfé, conectando-o com a colonialidade em Abya Yala, para assim pensar os possíveis caminhos da hermenêutica inter-religiosa feminista latino-americana e do Princípio Pluralista na América Latina. Utilizaremos autoras/res da teologia feminista latino-americana e do princípio pluralista para construir possíveis bordados a partir do nosso chão e luta, tais como Maricel-Mena López, Ivone Gebara, Cláudio de Oliveira Ribeiro entre outras/os pensadoras/os.Abstract Latin American feminist theology is intertwined with women's daily survival and spirituality, thus rethinking traditional concepts of subordinate bodies. It is the experience of women as a direction to challenge the notions of revelation and dogma. Interreligious dialogue has been built with the Westernizing lens of the World Religions Paradigm, which has fixed the notion of what Religion is. This article aims to challenge these concepts by weaving Latin American hermeneutics of interreligious dialogue, in this case, with the hands of feminist women. How can we understand the hermeneutics of inter-religious dialogue among Latin American women? We will dialogue with the theme based on the concept of interfaith dialogue, connecting with coloniality in Abya Yala to think about the possible paths of Latin American feminist inter-religious hermeneutics and the Pluralist Principle in Latin America. We will use authors from Latin American feminist theology and the pluralist principle to build possible embroidery from our ground and struggle, such as Maricel-Mena López, Ivone Gebara, Claudio de Oliveira Ribeiro among other thinkers.
Corpo e sexualidade na doutrina espírita: uma reflexão acerca das abordagens de Chico Xavier e Herculano Pires a partir do princípio pluralista | Body and sexuality in spiritist doctrine: a reflection on Chico Xavier and Herculano Pires’ approaches stemming from the pluralistic principle
Authors: Fonseca Grazyelle De Carvalho
Published: November 2020

Este artigo é uma reflexão acerca da relação do corpo e da sexualidade na doutrina espírita, formulada na França do século XIX, por Allan Kardec, e que tomou grande expressão no Brasil. Parte-se do questionamento de como a doutrina espírita aborda o corpo e o sexo na literatura - seja na literatura mediúnica, seja na literatura mais filosófica. Como metodologia, organizei uma fundamentação bibliográfica bem como utilizei a proposta teórico-metodológica do princípio pluralista. A partir de tal proposta, pôde-se compreender a possibilidade de se pensar a religião não somente pela via teológica mas também antropológica, na qual a temática do corpo e da sexualidade é importante. Por fim, concluo que o corpo é uma instância significante na doutrina, desde a intermediação entre o mundo invisível e o visível, as experiências e o processo de geração da vida. Abstract This essay intends to approach the relationship between body and sexuality in spiritist doctrine - formulated at France in the nineteenth century, by Allan Kardec, and that has currently a large expression in Brazil. How the doctrine conceived the body and the sex in the literature - whether in mediumistic or more philosophic? In methodology, I realized a bibliographical foundation and used the theoretical-methodological proposal named pluralist principle. Then, from this principle, we can comprehend the religion both from a theological approach and as anthropology perspective. Therefore, body and sexuality thematic are important. Finally, I conclude that the body is significant in spiritist doctrine, since the intermediation between invisible and visible worlds, the experiences and the process of generating life.
Intervenções com crianças e adolescentes em acolhimento institucional: uma revisão sistemática
Authors: Valin Tassiane Aparecida Ferreira , Rocha Giovana Veloso Munhoz da
Published: November 2020

O objetivo dessa revisão sistemática foi levantar estudos empíricos que tiveram o objetivo de minimizar ou prevenir problemas de comportamento em crianças e adolescentes em situação de acolhimento institucional. Foram utilizadas seis bases de dados: PsycINFO, SageJournals, Web of Science, PubMed/Medline, Lilacs e Scopus. Os critérios de seleção incluíram todos os estudos, publicados em inglês e português, disponíveis entre 2009 e 2019 que tivessem o objetivo avaliar a eficácia e aplicabilidade de intervenções para reduzir ou prevenir problemas de comportamento com essa população. Ao todo foram encontrados 155 estudos e após o processo de exclusão e elegibilidade, restaram 24 artigos incluídos em análise quantitativa. A qualidade dos estudos foi avaliada utilizando Cochrane Riskof Bias Tool e a Quality Assessment Tool. Verificou-se forte evidência do Multidimensional Treatment Foster Care (MTFC) na prevenção e tratamento de problemas de comportamento em crianças e adolescentes em acolhimento institucional.
Sources of widefield fluorescence from the brain
Authors: Waters Jack
Published: November 2020

Widefield fluorescence microscopy is used to monitor the spiking of populations of neurons in the brain. Widefield fluorescence can originate from indicator molecules at all depths in cortex and the relative contributions from somata, dendrites, and axons are often unknown. Here, I simulate widefield illumination and fluorescence collection and determine the main sources of fluorescence for several GCaMP mouse lines. Scattering strongly affects illumination and collection. One consequence is that illumination intensity is greatest ~300–400 µm below the pia, not at the brain surface. Another is that fluorescence from a source deep in cortex may extend across a diameter of 3–4 mm at the brain surface, severely limiting lateral resolution. In many mouse lines, the volume of tissue contributing to fluorescence extends through the full depth of cortex and fluorescence at most surface locations is a weighted average across multiple cortical columns and often more than one cortical area.
A Comparative Study on the Calculating of Thickness and Height at T-Shaped Branch for KS D 3595 Stainless Steel Pipe using the Results both the Finite Element Method and the Experiment
Authors: Nam Jun-Seok , Ryou Hong-Sun
Published: November 2020

Stainless steel pipe for general piping specified under the KS D 3595 standard is used as a substitute for carbon steel pipe in places where corrosion of coastal regions is a concern because there is little risk of corrosion. In order to install the branch pipe from the main pipe, the pipe is punched into the elliptical shape and the cone-shaped plug is pulled out of the main pipe to form a T-Shaped branch portion. However, there is a problem that is damaged when welding the pipe to the branch, but it is insufficient to understand the behavior of the material and the principle of damage due to plastic deformation when forming the branch. Hence, in this study, material behavior and stress were analyzed through finite element analysis. The diameter of the KS D 3595 stainless steel main was varied from 75 mm to 100 mm and the diameter of the branch pipe was varied from 25 mm to 80 mm. So, a total of eighteen cases were analyzed. The obtained results indicate that the maximum residual stress occurs in the central portion of the pipe along the longitudinal direction of the branch, and the residual stress increases as the size of the branch processing portion increases. Furthermore, in this study the minimum cutting height required for compatibility with the minimum thickness of the branching portion is reported.
Proposal of Air Supply Smoke Control System about Stair-case Considering Stack Effect & Opening of the Outside Door
Authors: Kim Yongkwang
Published: November 2020

Most of the special escape staircase smoke control systems for high-rise buildings in accordance with the national fire safety code NFSC 501A are constructed with smoke control only vestibule, making it difficult to expect a proper role in an emergency. This standard, which was created by introducing the concept of air supply pressurized smoke control 25 years ago, created Korea´s smoke control only vestibule, which was not found in developed countries, and has been mainly applied to it to fit into the poor architectural environment of the time. However, there is a fundamental flaw there, so the performance test for completion without occupants is passed, but in the presence of occupants, the performance does not come out properly and it is being blamed for being useless. In this regard, the author proposes a method of air supply pressurized smoke control for stair-case that avoid the smoke control method only vestibule, reduces the stack effect with good cost-effectiveness, and considers opening the outside entrance door of the stair-case.
Growth Performance of Organic Agriculture in India
Authors: Chadha Deepali , Srivastava S. K.
Published: November 2020

Organic agriculture is growing rapidly as an alternative strategy to modern farming methods. At present, only 1.5 per cent of the world’s agricultural land is organic. However, it has encountered a phenomenal rise over the past fourteen years (2005 to 2018) growing annually at a compound growth rate of 7.05 per cent; with 71.5 million hectares global organic land in 2018. However, India has witnessed a remarkable growth of 10.62 per cent during the ibid period and stood at ninth rank among other countries in terms of organic agricultural land (2018-19). The present study attempts to examine the trend and variability in growth of organic agricultural land (including both the cultivated and wild) from 2005 to 2018 at both the national and global level. Further, it explores the marketing patterns for organic food products and unveils those areas where more emphasis is needed and which issues are to be further investigated, addressed and improvised.
The Inhibition Potentials of Different Honey against Staphylococcus aureus, Escherichia coli and Bacillus species Isolated from Clinical Source
Authors: Patience Akani, Nedie , Samuel Amadi Wemedo, , Egbuchulem Njoku, Onyedikachi
Published: November 2020

As a result of the increased prevalence of antibiotic resistance among different bacteria, different plants and other natural products have been studied and found to be highly effective against pathogenic bacteria. Honey, over the years has been used as an antibacterial agent to treat certain infections caused by bacteria and is believed to be effective especially in rural areas. This study was thus aimed at comparing the effect of different honey samples against some pathogenic bacteria (Escherichia coli, Staphylococcus aureus and Bacillus cereus) isolated from clinical source. This study was carried out in the microbiology laboratory, department of microbiology Rivers State University Nigeria from January 2018 to August 2019. The antibacterial sensitivity test was carried out using agar well diffusion method while the Minimum inhibitory concentration and Minimum bactericidal concentration were determined using broth tube micro dilution technique in two fold dilution. The inhibition efficiency of the honey samples on the test organisms increased with increasing concentration from 20 to 100% as 100% concentration had the highest zone of inhibition. Staphylococcus aureus (6.33 mm – 26.33 mm) was the most sensitive to the honey samples while Bacillus cereus (0.00 – 19.67 mm) was less sensitive. At concentrations of 20 – 80%, raw and Rowse honey were more effective on E. coli compared to Princenic Global honey, while at 100%, Princenic Global honey was more effective on Staphylococcus aureus. Raw and Rowse honey were more effective at 20 -60% concentrations followed by Princenic Global honey; whereas at 80 -100% concentrations, Raw and Princenic Global honey were more effective. Bacillus cereus was resistancet to the honey samples at 20 – 60% but sensitive at 80 – 100% concentrations to Rowse, Raw and Princenic Global honey. The inhibition efficiency of the honey samples on the growth of the tested organisms was found to be dependent on the concentration and type of honey used, as well as they type of organism tested. The result of the minimum inhibitory and minimum bactericidal concentration showed that Staphylococcus aureus was inhibited most at a lower concentration of 25% compared to other bacteria isolates. All honey samples tested did not show any bactericidal effect but was bacteriostatic to some of the tested organisms. Pharmacological standardization and clinical evaluation on the effect of honey is essential before honey can be used as a preventive and curative measure to common diseases related to the tested bacterial species.
Adherence of Streptococcus mutans to Nanoceramic and Nanohybrid Resin Composites: An In vitro Study
Authors: Jaju Krishnakanth , Nasim Iffat
Published: November 2020

Streptococcus mutans (S. mutans) is one of the cariogenic microorganisms. The restorative materials which harbor a biofilm with high number of S. mutans can accelerate the occurrence of dental caries. The purpose of this study was to evaluate the adherence of S. mutans to nanoceramic and nanohybrid resin composites. Fifteen discs of each material (Nanohybrid resin composite, Nanoceramic resin composite) were prepared, polished, and sterilized in a gamma radiation chamber. Specimens were exposed to the S. mutans bacterial suspension (0.5 McFarland) and were incubated for 4 hours. Specimens were rinsed and sonicated in normal saline, 10 μl of the obtained suspension was cultured in a sterile blood agar medium. After 24 hours, the number of colony forming units of S. mutans was counted. A sterility test control was considered for each group of materials. The data was analyzed by Independent t test. The means and standard deviations of the logarithmic counts of the colonies on the surfaces of nanohybrid resin composites and nanoceramic resin composite were equal to 3.2±0.87 and 2.8±0.324 respectively. Ceram X Universal did not show any significant difference in the bacterial adhesion compared to Filtek Z350XT. Both composites showed similar behaviour in terms of S. mutans colonization in a simple biofilm formation model.
BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN
Authors: Deng Rong , Guo Yanmin , Li Lian , He Jianfeng , Qiang Zhe , Zhang Hailong , Chen Ran , Wang Yanli , Zhao Xian , Yu Jianxiu
Published: November 2020

Deubiquitinase BAP1 is an important tumor suppressor in several malignancies, but its functions and critical substrates in prostate cancer (PCa) remain unclear. Here, we report that the mRNA and protein expression levels of BAP1 are downregulated in clinical PCa specimens. BAP1 can physically bind to and deubiquitinate PTEN, which inhibits the ubiquitination‐mediated degradation of PTEN and thus stabilizes PTEN protein. Ectopically expressed BAP1 in PCa cells increases PTEN protein level and subsequently inhibits the AKT signaling pathway, thus suppressing PCa progression. Conversely, knockdown of BAP1 in PCa cells leads to the decrease in PTEN protein level and the activation of the Akt signaling pathway, therefore promoting malignant transformation and cancer metastasis. However, these can be reversed by the re‐expression of PTEN. More importantly, we found that BAP1 protein level positively correlates with PTEN in a substantial fraction of human cancers. These findings demonstrate that BAP1 is an important deubiquitinase of PTEN for its stability and the BAP1‐PTEN signaling axis plays a crucial role in tumor suppression.
Loss of STAT5A promotes glucose metabolism and tumor growth through miRNA‐23a‐AKT signaling in hepatocellular carcinoma
Authors: Jiang Yabo , Tao Yongzhen , Zhang Xiuping , Wei Xubiao , Li Min , He Xuxiao , Zhou Bin , Guo Weixing , Yin Huiyong , Cheng Shuqun
Published: November 2020

Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide. Here, we identified that increased miR‐23a expression in HCC tissues was associated with worse survival. More importantly, we found that STAT5A was a target of miR‐23a, whose levels significantly decreased in tumor tissues. Stable expression of STAT5A in Huh7 cells suppressed glucose metabolism and tumor growth. Finally, this study showed that increased miR‐23a negatively regulated STAT5A, which further activated AKT signaling to enable rapid metabolism for accelerated tumor growth in HCC. Taken together, our results demonstrated that the miR‐23a‐STAT5A‐AKT signaling pathway is critical to alter glucose metabolism in HCC and may offer new opportunities for effective therapy.
Effect of endurance exercise duration on muscle hypertrophy induced by functional overload
Authors: Shirai Takanaga , Obara Tsubasa , Takemasa Tohru
Published: November 2020

For many ball games, both resistance and endurance training are necessary to improve muscle strength and endurance capacity. Endurance training has been reported to inhibit muscle strength and hypertrophy, but some studies have reported that endurance exercise (EE) does not inhibit the effects of resistance exercise. Here, we examined the effect of short‐ or long‐duration EE on mouse skeletal muscle hypertrophy induced by functional overload (OL) at the molecular level. Plantaris muscle hypertrophy was induced by OL with synergist ablation in mice. Body mass was reduced with endurance training, but EE duration (30 or 90 min) had no effect. The ratio of plantaris muscle weight to body weight was higher in the OL and EE for 30 min (OL+EE30) and OL and EE for 90 min (OL+EE90) groups compared with the OL group. Expression of mechanistic target of rapamycin signaling proteins, which is related to protein synthesis and hypertrophy, was increased in the OL+EE30 group. Expression of Forkhead box‐containing protein O1, which is related to protein breakdown and atrophy, remained unchanged. However, microtubule‐associated protein 1 light chain 3, a known marker of autophagy, and MAFbx, which is related to protein breakdown, were significantly increased in the OL+EE90 group. Furthermore, markers of oxidative stress, ubiquitin and 4‐hydroxynonenal were also significantly increased in the OL+EE90 group compared with other groups. In conclusion, EE duration did not affect body mass and plantaris mass and did not interfere with mechanistic target of rapamycin signaling, but it did increase ubiquitinated proteins and oxidative stress. It is therefore necessary to consider training durations for EE when combining endurance and resistance training.
The Photo‐Hall Effect in High‐Mobility Organic Semiconductors
Authors: Bruevich Vladimir , Choi Hyun Ho , Podzorov Vitaly
Published: November 2020

High‐mobility crystalline organic semiconductors are important for applications in advanced organic electronics and photonics. Photogeneration and transport of mobile photocarriers in these materials, although very important, remain underexplored. The photo‐Hall effect can be used to address the fundamental charge transport properties of these functional molecular materials, without the need for fabricating complex transistor devices or chemical doping. Here, a photo‐Hall effect is demonstrated in organic semiconductors, using a benchmark molecular system rubrene as an experimental platform. It is shown that this technique can be used to directly measure the charge carrier mobility and photocarrier density, decouple the surface and bulk transport phenomena, and thus significantly deepen the understanding of the mechanism of photoconductivity in these high‐performance molecular materials.
High zT and Its Origin in Sb‐doped GeTe Single Crystals
Authors: Vankayala Ranganayakulu K. , Lan Tian‐Wey , Parajuli Prakash , Liu Fengjiao , Rao Rahul , Yu Shih Hsun , Hung Tsu‐Lien , Lee Chih‐Hao , Yano Shin‐ichiro , Hsing Cheng‐Rong , Nguyen Duc‐Long , Chen Cheng‐Lung , Bhattacharya Sriparna , Chen Kuei‐Hsien , Ou Min‐Nan , Rancu Oliver , Rao Apparao M. , Chen Yang‐Yuan
Published: November 2020

A record high zT of 2.2 at 740 K is reported in Ge0.92Sb0.08Te single crystals, with an optimal hole carrier concentration ≈4 × 1020 cm−3 that simultaneously maximizes the power factor (PF) ≈56 µW cm−1 K−2 and minimizes the thermal conductivity ≈1.9 Wm−1 K−1. In addition to the presence of herringbone domains and stacking faults, the Ge0.92Sb0.08Te exhibits significant modification to phonon dispersion with an extra phonon excitation around ≈5–6 meV at Γ point of the Brillouin zone as confirmed through inelastic neutron scattering (INS) measurements. Density functional theory (DFT) confirmed this phonon excitation, and predicted another higher energy phonon excitation ≈12–13 meV at W point. These phonon excitations collectively increase the number of phonon decay channels leading to softening of phonon frequencies such that a three‐phonon process is dominant in Ge0.92Sb0.08Te, in contrast to a dominant four‐phonon process in pristine GeTe, highlighting the importance of phonon engineering approaches to improving thermoelectric (TE) performance.
Profitability of using nitrogen fertilizer or inoculating soybean seed
Authors: Popp Michael P. , Purcell Larry C. , Ross W. Jeremy , Norsworthy Jacob S.
Published: November 2020

Applying supplemental fertilizer N or inoculating soybean [Glycine max (L.) Merr.] seed with Bradyrhizobium japonicum led to mixed yield responses. We assessed the profitability of seed inoculation, fertilizing with N, or both, across different planting dates using maturity group (MG) IV and MG V soybean cultivars under irrigated conditions. Planting dates ranged from late May to late June at Fayetteville, AR, and Pine Tree, AR, from 2017 to 2019. Urea fertilizer was applied at R2 at 0 or 56 kg N ha−1 using inoculated soybean. Similarly, non‐inoculated treatments ranged from 0, 28, 56, 112, to 168 kg N ha−1. Although fertilizer did increase yield, the response varied by planting date, was small, and only significant at p = .141 and .171 for linear and non‐linear effects of N, respectively. Seed inoculation had a small negative impact (89 kg ha−1) on yield (p = .0157). Using historical prices over the last 10 yr, optimal fertilizer rates ranged from 3.6 to 6.6 kg N ha−1 with an attendant average yield increase of 32 kg ha−1 for early planting and from 2.6 to 4.1 kg N ha−1 for late planting with an average yield gain of 24 kg ha−1. Regardless of timing of planting, the added yield less attendant fertilizer cost resulted in an average net gain of US$7.39 and $6.00 ha−1, for early and late planting, respectively. That net gain was insufficient to cover additional custom fertilizer application charges of $17.30 ha−1. Hence, inoculation and fertilizer N are not recommended.
Food supply chains and COVID‐19: A way forward
Authors: Kamble Sachin S. , Mor Rahul S.
Published: November 2020

Core Ideas

Food security is likely to be a big challenge post COVID‐19.

Disruptions suggest that a global recession could occur.

Agri‐food has become the priority industry.

Technological innovations, and short and resilient models will help recover food supply chains.
Eine enantioselektive elektronische Nase: Ein Array nanoporöser homochiraler MOF‐Filme zur stereospezifischen Erkennung chiraler Geruchsmoleküle
Authors: Okur Salih , Qin Peng , Chandresh Abhinav , Li Chun , Zhang Zejun , Lemmer Ulrich , Heinke Lars
Published: November 2020

Chiralität ist von wesentlicher Bedeutung in der Natur und oft entscheidend für biologischen Informationstransfer, z. B. mittels Geruchsmolekülen. Während die menschliche Nase die Enantiomere vieler chiraler Gerüche unterscheiden kann, bleibt die technische Umsetzung durch einen künstlichen Sensor oder eine elektronische Nase, e‐nose, eine große Herausforderung. Hier präsentieren wir ein Array von sechs Sensoren, die mit nanoporösen Metall‐organischen Gerüsten (MOFs) verschiedener homochiraler und achiraler Strukturen beschichtet sind. Dieses Array funktioniert wie eine enantioselektive elektronische Nase. Während die achiralen MOF‐Sensoren identische Reaktionen für beide Isomere eines chiralen Geruchsmoleküls zeigen, unterscheiden sich die Sensorsignale der homochiralen MOF‐Filme bei verschiedenen Enantiomeren. Mittels maschineller Lern‐Algorithmen ermöglichen die kombinierten Arraydaten die stereoselektive Identifizierung, hier für fünf Paare von chiralen Geruchsmolekülen getestet. Wir sind überzeugt, dass die “chiral‐MOF‐e‐nose”, welche chirale Gerüche enantioselektiv erkennen und unterscheiden kann, zur fortgeschrittenen technischen Geruchswahrnehmung beiträgt.
Nickel‐katalysierte intramolekulare 1,2‐Aryl‐Wanderung von mesoionischen Carbenen (iMICs)
Authors: Merschel Arne , Glodde Timo , Neumann Beate , Stammler Hans‐Georg , Ghadwal Rajendra S.
Published: November 2020

Die Ni‐katalysierte intramolekulare 1,2‐Verschiebung eines 2,6‐Diisopropylphenyl‐Substituenten (Dipp) von sieben mesoionischen Carbenen (iMICAr) 2 a–g (iMICAr=ArC{N(Dipp)}2CHC; Ar=Aryl) unter Bildung von 1,3‐Imidazolen (IMDAr) 3 a–g (IMDAr=ArC{N(Dipp)CHC(Dipp)N}) wird berichtet. Dieser Prozess impliziert die Spaltung einer N‐CDipp‐Bindung in 2 und die anschließende Knüpfung einer C‐CDipp‐Bindung, was in der NHC‐Chemie bislang unbekannt war. Die Überführung von 3 in Super‐iMICs (5) (S‐iMIC=ArC{N(Dipp)N(Me)C(Dipp)}C) wurde mit der Herstellung von Selen‐ (6), Gold‐(7) und Palladium‐Derivaten (8) gezeigt. Die Quantifizierung der stereoelektronischen Eigenschaften lässt hierbei eine deutliche Erhöhung der σ‐Donorstärke von 5 relativ zu klassischen NHCs erkennen. Bemerkenswert hierbei ist das “Buried Volume” von 5 (%Vbur=45), welches in iMICs dem bisher größten bekannten Wert entspricht. Katalytische Studien weisen auf eine hervorragende Aktivität von 5 hin, was mit den stereoelektronischen Eigenschaften der Liganden im Einklang ist.
A distributed adaptive scheme for multiagent systems
Authors: Imran Imil Hamda , Chen Zhiyong , Zhu Lijun , Fu Minyue
Published: November 2020

In traditional adaptive control, the certainty equivalence principle suggests a two‐step design scheme. A controller is first designed for the ideal situation assuming the uncertain parameter was known, and it renders a Lyapunov function. Then, the uncertain parameter in the controller is replaced by its estimation that is updated by an adaptive law along the gradient of Lyapunov function. This principle does not generally work for a multiagent system as an adaptive law based on the gradient of (centrally constructed) Lyapunov function cannot be implemented in a distributed fashion, except for limited situations. In this paper, we propose a novel distributed adaptive scheme, not relying on gradient of Lyapunov function, for general multiagent systems. In this scheme, asymptotic consensus of a second‐order uncertain multiagent system is achieved in a network of directed graph.
Distributed consensus control for networked linear agents via event‐triggered communications
Authors: Rong Lina , Hua Yuteng , Jiang Guo‐Ping
Published: November 2020

This paper deals with the distributed consensus of networked linear agents via event‐driven communications by exploring relative‐state and relative‐output feedbacks. First, an alternative event‐triggered consensus design is proposed, consisting of a distributed controller with the relative‐state feedback and an event‐based communication policy, both of which can avoid employing the eigenvalues of the Laplacian matrix. Under the proposed scheme, it is proved that the residual consensus error is bounded, which is dependent on the agent number, the deviation constant in the threshold function, and the associated algebraic Riccati equation. Next, the design is extended to the case of the output event‐driven consensus control by using local observers.
Family engagement in alternative provision
Authors: Page Damien
Published: November 2020

This article presents findings from research focusing on family engagement within alternative provision. With the existing literature on alternative provision scant, this article analyses the extensive assemblage of family engagement within settings as practitioners navigate complex family environments often characterised by poverty, crime and substance abuse. While settings create formalised structures of family engagement that prioritise a collaborative approach to children’s development—such as family learning days and daily positive phone calls—equally they work to attenuate the isolation and loneliness of families who feel as excluded as their child. Yet as important as structured engagement is, practitioners within alternative provision also engage in the improvised pragmatism of micro‐work—the work that other agencies won’t or can’t do, such as escorting parents to medical appointments, sourcing furniture to fill empty houses or talking a child out from under their bed. The article argues that family engagement in alternative provision is cyclical, with families informing staff of behavioural incidents or learning opportunities, information that rapidly personalises communicative and pedagogical strategies within schools. In return, teachers update parents at the end of the day, offering ideas for home learning or approaches to managing challenging behaviours. The article concludes by identifying six domains of family engagement—behavioural, emotional, safeguarding, functional, pedagogic and capacity building—that can be used within alternative provision settings to ensure a holistic approach that provides deep support to families to maximise the successful re‐engagement of children.
Neurological complications of pandemic A(H1N1)2009pdm, postpandemic A(H1N1)v, and seasonal influenza A
Authors: Radzišauskienė Daiva , Vitkauskaitė Monika , Žvinytė Karolina , Mameniškienė Rūta
Published: November 2020

Objectives

Not much is known about influenza‐associated neurological complications. We aimed to describe the case series of hospitalized patients who were confirmed with influenza A and presented with neurological symptoms in order to capture the broad spectrum of influenza clinical manifestation and suggest including influenza diagnostic in some neurological conditions.

Materials and methods

The inclusion criteria were age ≥ 18 and laboratory‐confirmed influenza presenting with neurological symptoms. Influenza‐associated neurological complication was described as a development of neurological symptom with no other origin. The outcomes were classified into 5 categories: 1. recovery with no significant disability; 2. minor disability (able to manage on their own); 3. moderate disability (requiring some help but able to walk without assistance); 4. severe disability (unable to walk without assistance and perform daily activities); 5. death.

Results

In total, 12 patients (five women and seven men) were enrolled, with age range 18–71 years old. Neurological complications of pandemic A(H1N1)2009pdm influenza developed in seven out of 69 (10.1%) hospitalized patients. The most common neurological complication was encephalopathy. Neurological complications developed in two out of 24 (8.3%) hospitalized patients during postpandemic (H1N1)V period. One patient presented with encephalopathy, another with meningoencephalitis. During the 2018 influenza season, there was one patient who has developed influenza A neurological complications. Overall, two out of 104 (1.9%) influenza A patients developed influenza‐associated neurological complications in 2019.

Conclusions

Every patient with unexplained neurological symptoms and signs similar to aseptic and septic meningitis/encephalitis has to be tested for influenza virus during epidemics and pandemics.
Intergroup helping during the coronavirus crisis: Effects of group identification, ingroup blame and third party outgroup blame
Authors: Zagefka Hanna
Published: November 2020

Two studies tested predictors of helping across national boundaries. British participants reported blame attributions for the coronavirus crisis, either to the British government (ingroup blame), or to the Chinese government (third party outgroup blame), and it was tested whether this was associated with intentions to donate money to help outgroup members suffering from effects of the coronavirus crisis in the world's poorer countries. It was hypothesized that strength of identification with the national ingroup would be negatively associated with blame attributions to the ingroup, and that it would be positively associated with blame attributions to a third party outgroup. Blame attributions were predicted in turn to be related to outgroup helping, with ingroup blame being positively associated with helping intentions, and third party outgroup blame being negatively associated with helping intentions. Support for these predictions were found in one exploratory (N = 100) and one confirmatory (N = 250) study.
Novel nucleolar localization of clusterin and its associated functions in human oral cancers: An in vitro and in silico analysis
Authors: Kadam Rajashree , Harish Mahalakshmi , Dalvi Kajal , Teni Tanuja
Published: November 2020

Clusterin (CLU), a multifunctional chaperonic glycoprotein associated with diverse cellular functions has been shown to act as an oncogene or tumour suppressor gene in different cancers, implying a dual role in tumorigenesis. Here, we investigated the expression of CLU isoforms, their subcellular localization and functional significance in oral cancer cells. Significant downregulation of secretory CLU (sCLU) transcripts was observed in oral cancer cell lines and tumours versus normal cells while the nuclear CLU (nCLU) transcripts were undetectable. We demonstrated for the first time the nucleolar localization of sCLU, its response to different nucleolar stresses and association with cajal bodies post nucleolar stress. Functionally, knockdown of CLU revealed its negative association with ribosome biogenesis implying a possible tumour suppressor like role in oral cancers. Further, loss of sCLU in these cells also resulted in altered nuclear morphology and shrunken tubulin filaments. In addition, the levels of nucleolar Nucleophosmin 1(NPM1) and Fibrillarin, known to regulate nuclear morphology were downregulated indicating a possible role of sCLU in their stabilization. Further, an in silico docking approach to gain insights into the interaction of sCLU with nucleolar proteins NPM1, Fibrillarin, UBF and Nucleolin, revealed the involvement of a conserved region comprising of amino acid residues 140‐155 of sCLU β‐chain, specifically via the Phe152 residue in hydrophobic interactions with these client nucleolar proteins indicating a possible stabilizing or regulatory role of sCLU.

Significance of the study

This is the first study to demonstrate the nucleolar localization of sCLU and its associated functions in oral cancer cells. Downregulation of sCLU in oral cancer tissues and cell lines, and its negative association with ribogenesis suggest its tumour suppressor like role in oral cancers. The possible role of sCLU in stabilization or regulation of different nucleolar proteins thereby impacting their functions is also implicated.
Metastatic follicular thyroid cancer in a patient with Birt‐Hogg‐Dubé syndrome
Authors: Bongetti Elisa K. , Raj Rajesh , Cooke Duncan R. , Mathew Mathew C.
Published: November 2020

Birt‐Hogg‐Dubé syndrome (BHDS) is an extremely rare genetic condition that predisposes to renal cell carcinoma. This case describes a novel case of a patient with BHDS who also develops follicular thyroid cancer.
Granulocyte‐colony stimulating factor‐producing uterine cervical cancer treated with chemoradiotherapy: A case report with mutation analysis and literature review
Authors: Shiba Shintaro , Oike Takahiro , Ando Ken , Yoshimoto Yuya , Takayama Yoshiyasu , Ohno Tatsuya
Published: November 2020

Granulocyte‐colony stimulating factor‐producing uterine cervical cancer is a rare aggressive disease, which may be genetically distinct from other uterine cervical cancers.
Generalized simultaneous component analysis of binary and quantitative data
Authors: Song Yipeng , Westerhuis Johan A. , Aben Nanne , Wessels Lodewyk F. A. , Groenen Patrick J. F. , Smilde Age K.
Published: November 2020

In the current era of systems biology research, there is a need for the integrative analysis of binary and quantitative genomics data sets measured on the same objects. One standard tool of exploring the underlying dependence structure present in multiple quantitative data sets is the simultaneous component analysis (SCA) model. However, it does not have any provisions when a part of the data are binary. To this end, we propose the generalized SCA (GSCA) model, which takes into account the distinct mathematical properties of binary and quantitative measurements in the maximum likelihood framework. Like in the SCA model, a common low‐dimensional subspace is assumed to represent the shared information between these two distinct types of measurements. To achieve a low rank solution, we propose to use a concave variant of the nuclear norm penalty. An efficient majorization algorithm is developed to fit this model with different concave penalties. Realistic simulations (low signal‐to‐noise ratio and highly imbalanced binary data) are used to evaluate the performance of the proposed model in recovering the underlying structure. Also, a missing value based cross‐validation procedure is implemented for model selection. We illustrate the usefulness of the GSCA model for exploratory data analysis of quantitative gene expression and binary copy number aberration measurements obtained from the GDSC1000 data sets.
On the Structure of Intermediates in Enyne Gold(I)‐Catalyzed Cyclizations: Formation of trans‐Fused Bicyclo[5.1.0]octanes as a Case Study
Authors: Escofet Imma , Armengol‐Relats Helena , Bruss Hanna , Besora Maria , Echavarren Antonio M.
Published: November 2020

The nature of cyclopropyl gold(I) carbene‐type intermediates has been reexamined as part of a mechanistic study on the formation of cis‐ or trans‐fused bicyclo[5.1.0]octanes in a gold(I)‐catalyzed cascade reaction. Benchmark of DFT methods together with QTAIM theory and NBO analysis confirms the formation of distinct intermediates with carbenic or carbocationic structures in the cycloisomerizations of enynes.
Late‐Stage C(sp2)−H Functionalization: A Powerful Toolkit To Arm Natural Products for In Situ Proteome Profiling?
Authors: Lim Ying‐Jie , Kuang Yulong , Wu Jie , Yao Shao Q.
Published: November 2020

The comprehensive investigation of target interactions from native cellular environments is of paramount importance for natural products and related bioactive compounds in drug discovery and chemical biology. Current chemoproteomic tools, such as in situ proteome profiling can do so effectively, but rely heavily on “tagged” probes that are accessible through traditional organic synthesis at the reactive sites of a compound, which may often be required for target binding. Late‐stage functionalization may resolve such limitations by tagging compounds in a single step at biologically inert C−H bonds. Herein, recent advances in late‐stage C(sp2)−H functionalization of (hetero)arenes, which are present in many natural products, are summarized, and new toolkits for more widespread use of such strategies to install natural products with next‐generation “minimalist” linkers for in situ proteome profiling are suggested.
Evaluation of Water‐Soluble Mannich Base Prodrugs of 2,3,4,5‐Tetrahydroazepino[4,3‐b]indol‐1(6H)‐one as Multitarget‐Directed Agents for Alzheimer's Disease
Authors: Purgatorio Rosa , de Candia Modesto , Catto Marco , Rullo Mariagrazia , Pisani Leonardo , Denora Nunzio , Carrieri Antonio , Nevskaya Alisa A. , Voskressensky Leonid G. , Altomare Cosimo D.
Published: November 2020

Different Mannich base derivatives have been studied with the aim of addressing the poor aqueous solubility of the recently disclosed 6‐phenethyl‐2,3,4,5‐tetrahydroazepino[4,3‐b]indol‐1(6H)‐one (1), a human butyrylcholinesterase inhibitor (hBChE, IC5013 nM) and protective agent in NMDA‐induced neurotoxicity, in in vivo assays. The N‐(4‐methylpiperazin‐1‐yl)methyl derivative 2 c showed a 50‐fold increase in solubility in pH 7.4‐buffered solution, high stability in serum and (half‐life >24 h) and rapid (<3 min) conversion to 1 at acidic pH. Although less active than 1, 2 c retained moderate hBChE inhibition (IC50=3.35 μM) and a significant protective effect against NMDA‐induced neurotoxicity at 0.1 μM. Moreover, 2 c resulted a weaker serum albumin binder than 1, could pass the blood–brain barrier, and exerted negligible cytotoxicity on HepG2 cells. These findings suggest that 2 c could be a water‐soluble prodrug candidate of 1 for oral administration or a slow‐release injectable derivative in in vivoAlzheimer's disease models.