bluuebunny/crossref_metadata_2025 huggingface dataset:
Performance Improvement of a Darrieus Tidal Turbine with Active Variable Pitch
Authors: Delafin Pierre-Luc , Deniset François , Astolfi Jacques André , Hauville Frédéric
Published: January 2021

Vertical axis turbines, also called Darrieus turbines, present interesting characteristics for offshore wind and tidal applications but suffer from vibrations and a lower efficiency than the more conventional horizontal axis turbines. The use of variable pitch, in order to control the angle of attack of the blades continuously during their rotation, is considered in this study to overcome these problems. 2D blade-resolved unsteady Reynolds-Averaged Navier–Stokes (RANS) simulations are employed to evaluate the performance improvement that pitching blades can bring to the optimal performance of a three-straight-blade vertical axis tidal turbine. Three pitching laws are defined and tested. They aim to reduce the angle of attack of the blades in the upstream half of the turbine. No pitching motion is used in the downstream half. The streamwise velocity, monitored at the center of the turbine, together with the measurement of the blades’ angle of attack help show the effectiveness of the proposed pitching laws. The decrease in the angle of attack in the upstream half of a revolution leads to a significant increase in the power coefficient (+40%) and to a better balance of the torque generated in the upstream and downstream halves. Both torque and thrust ripples are therefore significantly reduced.
Double-Layer Metal Foams for Further Heat Transfer Enhancement in a Channel: An Analytical Study
Authors: Donmus Sinem , Mobedi Moghtada , Kuwahara Fujio
Published: January 2021

A local thermal non-equilibrium analysis of heat and fluid flow in a channel fully filled with aluminum foam is performed for three cases: (a) pore density of 5 PPI (pore per inch), (b) pore density of 40 PPI, and (c) two different layers of 5 and 40 PPI. The dimensionless forms of fully developed heat and fluid flow equations for the fluid phase and heat conduction equation for the solid phase are solved analytically. The effects of interfacial heat transfer coefficient and thermal dispersion conductivity are considered. Analytical expressions for temperature profile of solid and fluid phases, and also the channel Nusselt number (NuH) are obtained. The obtained results are discussed in terms of the channel-based Reynolds number (ReH) changing from 10 to 2000, and thickness ratio between the channel height and sublayers. The Nusselt number of the channel with 40 PPI is always greater than that of the 5 PPI channel. It is also greater than the channel with two-layer aluminum foams until a specific Reynolds number then the Nusselt number of the channel with two-layer aluminum foams becomes greater than the uniform channels due to the higher velocity in the outer region and considerable increase in thermal dispersion.
Transport Cost Estimation Model of the Agroforestry Biomass in a Small-Scale Energy Chain
Authors: Sperandio Giulio , Acampora Andrea , Civitarese Vincenzo , Bajocco Sofia , Bascietto Marco
Published: January 2021

The delivery of biomass products from the production place to the point of final transformation is of fundamental importance within the constitution of energy chains based on biomass use as a renewable energy source. Transport can be one of the most economically expensive operations of the entire biomass energy production process, which limits choices in this sector, often inhibiting any expansive trends. A geographic identification, through remote sensing and photo-interpretation, of the different biomass sources was used to estimate the potential available biomass for energy in a small-scale supply chain. This study reports on the sustainability of transport costs calculated for different types of biomass sources available close a biomass power plant of a small-scale energy supply chain, located in central Italy. To calculate the transport cost referred to the identified areas we used the maximum travel time parameter. The proposed analysis allows us to highlight and visualize on the map the areas of the territory characterized by greater economic sustainability in terms of lower transport costs of residual agroforestry biomass from the collection point to the final point identified with the biomass power plant. The higher transport cost was around €40 Mg−1, compared to the lowest of €12 Mg−1.
Quest of Intelligent Research Tools for Rapid Evaluation of Fish Quality: FTIR Spectroscopy and Multispectral Imaging Versus Microbiological Analysis
Authors: Govari Maria , Tryfinopoulou Paschalitsa , Parlapani Foteini F. , Boziaris Ioannis S. , Panagou Efstathios Z. , Nychas George-John E.
Published: January 2021

The aim of the present study was to assess the microbiological quality of farmed sea bass (Dicentrarchus labrax) fillets stored under aerobic conditions and modified atmosphere packaging (MAP) (31% CO2, 23% O2, 46% Ν2,) at 0, 4, 8, and 12 °C using Fourier transform infrared (FTIR) spectroscopy and multispectral imaging (MSI) in tandem with data analytics, taking into account the results of conventional microbiological analysis. Fish samples were subjected to microbiological analysis (total viable counts (TVC), Pseudomonas spp., H2S producing bacteria, Brochothrix thermosphacta, lactic acid bacteria (LAB), Enterobacteriaceae, and yeasts) and sensory evaluation, together with FTIR and MSI spectral data acquisition. Pseudomonas spp. and H2S-producing bacteria were enumerated at higher population levels compared to other microorganisms, regardless of storage temperature and packaging condition. The developed partial least squares regression (PLS-R) models based on the FTIR spectra of fish stored aerobically and under MAP exhibited satisfactory performance in the estimation of TVC, with coefficients of determination (R2) at 0.78 and 0.99, respectively. In contrast, the performances of PLS-R models based on MSI spectral data were less accurate, with R2 values of 0.44 and 0.62 for fish samples stored aerobically and under MAP, respectively. FTIR spectroscopy is a promising tool to assess the microbiological quality of sea bass fillets stored in air and under MAP that could be effectively employed in the future as an alternative method to conventional microbiological analysis.
U.S. Consumer Demand for Plant-Based Milk Alternative Beverages: Hedonic Metric Augmented Barten’s Synthetic Model
Authors: Yang Tingyi , Dharmasena Senarath
Published: January 2021

Consumers in the U.S. increasingly prefer plant-based milk alternative beverages (abbreviated “plant milk”) to conventional milk. This study is motivated by the need to take into consideration varied nutritional and qualitative attributes in plant milk to examine consumers’ purchasing behavior and estimate demand elasticities which are achieved by a new approach combing hedonic pricing model with Barten’s synthetic demand system. The method of estimation is enlightened from the common practice of companies differentiating their products in multidimensions in terms of attributes. A research dataset was uniquely created by associating the products’ purchase data from Nielsen Homescan dataset with exclusive first-hand nutritional data. Estimations began with creating a multidimensional hedonic attribute space based on the qualitative information of different types of plant milk and conventional milk available to consumers and then calculating the hedonic distances by Euclidean distance measurement to reparametrize Barten’s synthetic demand system. Estimation results showed that the highest own-price elasticity pertained to soy milk which was −0.25. Three plant milk types had inelastic demand. Soy milk exerted substituting effects on all types of conventional milk products and vice versa. Soy milk, rice milk and almond milk entertained complementary relationships between each other and four types of conventional milk were strong substitutes within the group.
Cole-Impedance Model Representations of Right-Side Segmental Arm, Leg, and Full-Body Bioimpedances of Healthy Adults: Comparison of Fractional-Order
Authors: Freeborn Todd J. , Critcher Shelby
Published: January 2021

The passive electrical properties of a biological tissue, referred to as the tissue bioimpedance, are related to the underlying tissue physiology. These measurements are often well-represented by a fractional-order equivalent circuit model, referred to as the Cole-impedance model. Objective: Identify if there are differences in the fractional-order (α) of the Cole-impedance parameters that represent the segmental right-body, right-arm, and right-leg of adult participants. Hypothesis: Cole-impedance model parameters often associated with tissue geometry and fluid (R∞, R1, C) will be different between body segments, but parameters often associated with tissue type (α) will not show any statistical differences. Approach: A secondary analysis was applied to a dataset collected for an agreement study between bioimpedance spectroscopy devices and dual-energy X-ray absoptiometry, identifying the Cole-model parameters of the right-side body segments of N=174 participants using a particle swarm optimization approach. Statistical testing was applied to the different groups of Cole-model parameters to evaluate group differences and correlations of parameters with tissue features. Results: All Cole-impedance model parameters showed statistically significant differences between body segments. Significance: The physiological or geometric features of biological tissues that are linked with the fractional-order (α) of data represented by the Cole-impedance model requires further study to elucidate.
Modulation and Characterization of Wax-Based Olive Oil Organogels in View of Their Application in the Food Industry
Authors: Silva Pedro M. , Martins Artur J. , Fasolin Luiz H. , Vicente António A.
Published: January 2021

Olive oil has recognized health benefits but lacks structural resilience to act in a similar fashion as do the typically used triglycerides (TAGs) when applied in food manufacturing. Therefore, olive oil structuring is critical to widening its use as a healthier alternative in spreadable products. Foreseeing the development of an application for the food industry, three types of natural waxes were used as organogelators, generating olive oil organogels with distinct properties. Retail-simulated storage conditions were used to mimic real-life industrial and commercial use. Organogel systems were evaluated according to their oxidation stability and textural and rheological properties. Textural and rheological parameters increased in response to increasing gelator concentration, while oxidation values (below 1.5 meq O2·kg−1) remained within legal limits. Organogels displayed similar textural properties to those of commercially available spreadable products, while displaying a low critical gelation concentration. In short, it was shown that tailoring the physicochemical properties of organogels towards specific applications is possible. The produced organogels showed similar properties to the ones of commercially available spreadable products, revealing favourable oxidative profiles. Therefore, an industrial application can be easily foreseen, building on the natural characteristics of olive oil as a healthier alternative to current spreadable products.
Possibilities and Challenges in Providing Psychotherapeutic Interventions to Meet the Needs of the Latinx Population in the United States
Authors: Lombana Yaneth
Published: January 2021

The mental health system in the United States faces challenges in adequately engaging the Latinx population with modalities that conform to the Latinx worldview, which demands incorporating holistic, family-centric, and trauma-informed models of treatment. Service provision and innovation is hampered by lack of research focusing on this population, the low numbers of Latinx clinicians available, and the lack of treatment adaptations to meet their needs. Psychotherapeutic interventions employed in the Latin American context are potentially useful when working with acculturating Latinx. In this article attention is given to barriers and facilitators for incorporating Family constellation therapy—a holistic trauma-informed treatment modality that offers conflict resolution through connection with ancestry.
Brief Notes on Geodiversity and Geoheritage Perception by the Lay Public
Authors: Kubalíková Lucie , Bajer Aleš , Balková Marie
Published: January 2021

Geodiversity has an irreplaceable significance for both biodiversity and for human society as it has numerous functions and offers various benefits and services. These have been already recognized and assessed by using numerous approaches and methods (e.g., geosite assessment methods, geodiversity indexes, and evaluation of geodiversity functions within the concept of ecosystem services). Nearly all these procedures were elaborated by professionals in the Earth sciences or related domains. The assessment of geodiversity functions and services within nature conservation by the public was not the subject of detailed research yet (with an exception of geotourist assessment). This communication presents the results of a pilot research that is focused on the analysis and interpretation of the public opinion on geodiversity and geoconservation. The data were collected by using the semi-structured questionnaire, and based on them, the interpretation was done and comparison or confrontation with original hypotheses was undertaken.
Sub-Clinical Effects of Outdoor Smoke in Affected Communities
Authors: O’Dwyer Thomas , Abramson Michael J. , Straney Lahn , Salimi Farhad , Johnston Fay , Wheeler Amanda J. , O’Keeffe David , Haikerwal Anjali , Reisen Fabienne , Hopper Ingrid , Dennekamp Martine
Published: January 2021

Many Australians are intermittently exposed to landscape fire smoke from wildfires or planned (prescribed) burns. This study aimed to investigate effects of outdoor smoke from planned burns, wildfires and a coal mine fire by assessing biomarkers of inflammation in an exposed and predominantly older population. Participants were recruited from three communities in south-eastern Australia. Concentrations of fine particulate matter (PM2.5) were continuously measured within these communities, with participants performing a range of health measures during and without a smoke event. Changes in biomarkers were examined in response to PM2.5 concentrations from outdoor smoke. Increased levels of FeNO (fractional exhaled nitric oxide) (β = 0.500 [95%CI 0.192 to 0.808] p < 0.001) at a 4 h lag were associated with a 10 µg/m3 increase in PM2.5 levels from outdoor smoke, with effects also shown for wildfire smoke at 4, 12, 24 and 48-h lag periods and coal mine fire smoke at a 4 h lag. Total white cell (β = −0.088 [−0.171 to −0.006] p = 0.036) and neutrophil counts (β = −0.077 [−0.144 to −0.010] p = 0.024) declined in response to a 10 µg/m3 increase in PM2.5. However, exposure to outdoor smoke resulting from wildfires, planned burns and a coal mine fire was not found to affect other blood biomarkers.
A Longitudinal Exploration of Match Running Performance during a Football Match in the Spanish La Liga: A Four-Season Study
Authors: Pons Eduard , Ponce-Bordón José Carlos , Díaz-García Jesús , López del Campo Roberto , Resta Ricardo , Peirau Xavier , García-Calvo Tomas
Published: January 2021

This study aimed to analyze and compare the match running performance during official matches across four seasons (2015/2016–2018/2019) in the top two professional leagues of Spanish football. Match running performance data were collected from all matches in the First Spanish Division (Santander; n = 1520) and Second Spanish Division (Smartbank; n = 1848), using the Mediacoach® System. Total distance and distances of 14–21 km·h−1, 21–24 km·h−1, and more than 24 km·h−1, and the number of sprints between 21 and 24 km·h−1 and more than 24 km·h−1 were analyzed. The results showed higher total distances in the First Spanish Division than in the Second Spanish Division (p < 0.001) in all the variables analyzed. Regarding the evolution of both leagues, physical demands decreased more in the First Spanish Division than in the Second Spanish Division. The results showed a decrease in total distance and an increase in the high-intensity distances and number of sprints performed, although a clearer trend is perceived in the First Spanish Division (p < 0.001; p < 0.01, respectively). Knowledge about the evolution of match running performance allows practitioners to manage the training load according to the competition demands to improve players’ performances and reduce the injury rate.
Effects of the COVID-19 Pandemic on the Budgetary Mechanism Established to Cover Public Health Expenditure. A Case Study of Romania
Authors: Onofrei Mihaela , Cigu Elena , Gavriluta (Vatamanu) Anca-Florentina , Bostan Ionel , Oprea Florin
Published: January 2021

The COVID-19 pandemic stressed the importance of understanding the sources of vulnerabilities that can lead to a financial crisis and highlighted the predominant impact on health systems. Firstly, the paper aims to conduct a retrospective analysis of the Romanian health care system, over the period of time 1985–2019, based on our own computed sustainability index for public health. Secondly, using the Gregory-Hansen cointegration method, we provide new evidence on the causal relationship between health expenditure and GDP for Romania over the period of time 1985–2017. Based on the retrospective analysis of the long-run co-movement between health spending and GDP, the study allows one to prospectively examine not only the effects of the COVID-19 pandemic on health care spending, but also to reveal the government’s fiscal position and vulnerabilities. Our results highlight the intergenerational costs related to the policy incoherence roadmap and regulatory fragmentation, stressing the importance of economic system resilience through fiscal diligence and the consolidation of the institutional context.
The Exposome Approach to Decipher the Role of Multiple Environmental and Lifestyle Determinants in Asthma
Authors: Guillien Alicia , Cadiou Solène , Slama Rémy , Siroux Valérie
Published: January 2021

Asthma is a widespread respiratory disease caused by complex contribution from genetic, environmental and behavioral factors. For several decades, its sensitivity to environmental factors has been investigated in single exposure (or single family of exposures) studies, which might be a narrow approach to tackle the etiology of such a complex multifactorial disease. The emergence of the exposome concept, introduced by C. Wild (2005), offers an alternative to address exposure–health associations. After presenting an overview of the exposome concept, we discuss different statistical approaches used to study the exposome–health associations and review recent studies linking multiple families of exposures to asthma-related outcomes. The few studies published so far on the association between the exposome and asthma-related outcomes showed differences in terms of study design, population, exposome definition and statistical methods used, making their results difficult to compare. Regarding statistical methods, most studies applied successively univariate (Exposome-Wide Association Study (ExWAS)) and multivariate (adjusted for co-exposures) (e.g., Deletion–Substitution–Addition (DSA) algorithm) regression-based models. This latest approach makes it possible to assess associations between a large set of exposures and asthma outcomes. However, it cannot address complex interactions (i.e., of order ≥3) or mixture effects. Other approaches like cluster-based analyses, that lead to the identification of specific profiles of exposure at risk for the studied health-outcome, or mediation analyses, that allow the integration of information from intermediate biological layers, could offer a new avenue in the understanding of the environment–asthma association. European projects focusing on the exposome research have recently been launched and should provide new results to help fill the gap that currently exists in our understanding of the effect of environment on respiratory health.
The Meaning and Factors That Influence the Concept of Body Image: Systematic Review and Meta-Ethnography from the Perspectives of Adolescents
Authors: Tort-Nasarre Glòria , Pollina Pocallet Mercè , Artigues-Barberà Eva
Published: January 2021

Community care nurses educate adolescents about body image, but their interventions appear to be ineffective. Body dissatisfaction predicts unhealthy behaviors among adolescents. This study aimed to understand the meanings and factors that influence the concept of body image through a systematic review and meta-ethnography of qualitative studies from the perspective of adolescents. Ten studies published from 2009–2019 were identified by a search of relevant systematic databases between September and December 2019. The review followed the seven steps of meta-ethnography developed by Noblit and Hare, including a line-of-argument. The synthesis revealed six themes: self-perception of body image; opinions of friends and colleagues; opinions of family; specific features of the school environment; expectations perceived across the mass-media; and strategies, practices, and self-management of body image. An explanatory model was developed that showed adolescents’ development of body image and the path towards its establishment. In conclusion, these results should be considered to implement strategies to promote a healthy body image in adolescents by community health and mental health nurses.
Environmental Microbial Contamination during Cystic Fibrosis Group-Based Psychotherapy
Authors: Rossitto Martina , Tabarini Paola , Tuccio Guarna Assanti Vanessa , Montemitro Enza , Pompilio Arianna , Fiscarelli Ersilia Vita
Published: January 2021

Living with cystic fibrosis (CF) exposes patients to the risk of developing anxiety and depression, with therapeutic compliance reduction, hospitalization increase, and quality of life and health outcomes deterioration. As pulmonary infections represent the major cause of morbidity and mortality in patients with CF, environmental contamination due to droplet dispersion and the potential transmission from environment to such patients should be prevented. Therefore, in-person contact, including group-based psychotherapy, are strongly discouraged. Nevertheless, group sharing of disease-related experiences represents a way to recover the inner resources essential for dealing with a chronic pathology. Keeping in mind the guidelines for infection control, the aim of this study is to evaluate the risk of the dissemination of microorganisms in a restricted environment where patients with CF attend group psychotherapy sessions. Five patients, selected according to their microbiological status, attended 32 group-based psychological/psychoanalytic meetings. Before each session, they were asked to observe the infection control recommendations. Microbiological environmental monitoring (MEM) has been performed to evaluate both air and surface contamination. As reported, a strict observation of standard precautions allows one to avoid environmental contamination by pathogens of the CF respiratory tract. Although infection control guidelines discourage group-based psychological/psychoanalytic interventions, our observations report the feasibility and safety of group psychotherapy when strict precautions are taken.
Effects of Oral Probiotics on Subjective Halitosis, Oral Health, and Psychosocial Health of College Students: A Randomized, Double-Blind, Placebo-Controlled Study
Authors: Lee Dong-Suk , Kim Myoungsuk , Nam Seoul-Hee , Kang Mi-Sun , Lee Seung-Ah
Published: January 2021

Altogether, 81% of Korean college students experience halitosis and concomitant psychosocial problems such as depression and lowered self-esteem, as well as poor oral-health-related quality of life. Although halitosis causes many social and psychological problems among college students, there have been no reports of improvement interventions. This study aimed to identify the effects of ingesting tablets of the oral probiotic Weissella cibaria CMU (Chonnam Medical University, Gwangju, Korea) on halitosis and examine its effects on psychosocial indicators. This was a randomized, double-blind, placebo-controlled trial. The participants were randomly assigned to the experimental group or the control group. They ingested W. cibaria CMU or the placebo, depending on which group they belonged to, before going to bed daily for eight weeks. The measured indicators were subjective halitosis, subjective oral-health status, depression, self-esteem, and oral-health-related quality of life. Measurements were at baseline and eight weeks later. The participants showed statistically significant differences in subjective halitosis and oral-health-related quality of life. For college students with halitosis, intake of the oral probiotic for eight weeks could be a useful nursing intervention for reducing halitosis and improving oral-health-related quality of life.
Trauma, Sleep and Mental Health Problems in Low-Income Young Adults
Authors: Fusco Rachel A. , Yuan Yan , Lee Hyunji , Newhill Christina E.
Published: January 2021

Low-income young adults are more likely to have exposure to trauma, which increases risk for mental health problems. Although adequate sleep promotes good health, people with histories of trauma are more likely to have sleep problems. The current study explored whether poor sleep mediated the relationship between trauma exposure and mental health. A sample of 143 low-income 18–24-year-old young adults completed depression, anxiety, and trauma exposure measures and wore sleep monitors for four nights. Structural equation modeling (SEM) was used to examine both direct and indirect effects of variables. Results showed that higher trauma exposure was associated with depression and anxiety. Mean sleep hours per night was fewer than six, far below recommended guidelines for optimal health and functioning. Fewer sleep hours partially mediated the relationship between both trauma exposure and depression and anxiety, and the direct effect from trauma remained significant after adjusting for the partial mediation from sleep.
Effects of Variations in Color and Organ of Color Expression in Urban Ornamental Bamboo Landscapes on the Physiological and Psychological Responses of College Students
Authors: Wang Yuqian , Qu Huahong , Bai Tong , Chen Qibing , Li Xi , Luo Zhenghua , Lv Bingyang , Jiang Mingyan
Published: January 2021

Visual characteristics (e.g., the color and shape) of ornamental plants can significantly affect their beneficial influence on humans. Prior research, however, has largely focused on the effects of the color or shape of flowers and the impact of differences in the visual appearance of foliage plants and plants with ornamental stalks has not yet been fully explored. This study examined the psychophysiological effects of urban ornamental bamboos that expressed different colors on different organs. Three hundred Chinese college students participated in the experiment. They were randomly assigned to view images of five ornamental bamboo landscapes with the following different visual characteristics: green stalks (GS) non-green stalks (NGS) multicolored stalks (MS) green leaves (GL) and multicolored leaves (ML). Before and after viewing the images, their EEG, blood pressure, pulse, profile of mood states (POMS) score, and state-trait anxiety inventory (STAI) score were measured. The results showed that ornamental bamboo landscapes have extremely significant beneficial psychophysiological effects as compared to urban landscapes. After viewing landscapes in the NGS and MS groups, EEG, blood pressure, and pulse rate of subjects showed more beneficial changes. Significant gender differences were observed only in systolic blood pressure and in the vigor score. In addition, an extremely significant interaction between color and organ of color expression was observed on systolic and diastolic blood pressure. Organ of expression had significant main effects on all the physiological indicators and the fatigue, vigor, and irritability scores, while color only had a main effect on systolic blood pressure. Our study concluded that viewing urban ornamental bamboo landscapes with different visual characteristics has different effects on humans. With regards to ornamental bamboo, the organ expressing the color had a greater impact on psychophysiological responses than did the type of color itself. These study results can provide guidance for landscape construction of urban greening.
Degradation of Bisphenol A in an Aqueous Solution by a Photo-Fenton-Like Process Using a UV KrCl Excilamp
Authors: Aseev Denis , Batoeva Agniya , Sizykh Marina , Olennikov Daniil , Matafonova Galina
Published: January 2021

Bisphenol A (BPA), a precursor to important plastics, is regarded as a common aquatic micropollutant with endocrine-disrupting activity. In the present study, we explored the capability of a UV KrCl excilamp (222 nm) to degrade BPA by a photo-Fenton-like process using persulfate under flow-through conditions. The first-order rate constants of degradation were obtained and the mineralization of dissolved organic carbon (DOC) was estimated. The results showed complete BPA degradation and high DOC mineralization (70–97%). A comparative analysis of degradation rates and DOC removal in the examined systems (UV, Fe2+/S2O82−, UV/S2O82− and UV/Fe2+/S2O82−) revealed a significant synergistic effect in the photo-Fenton-like system (UV/Fe2+/S2O82−) without the accumulation of toxic intermediates. This indicated that the BPA was oxidized via the conjugated radical chain mechanism, which was based on the photo-induced and catalytic processes involving HO• and SO4−• radicals. The primary intermediates of BPA degradation in the UV/Fe2+/S2O82− system were identified by HPLC/MS and the oxidation pathway was proposed. The high performance of the photo-Fenton-like process employing a quasi-monochromatic UV radiation of a KrCl excilamp offers promising potential for an efficient removal of such micropollutants from aqueous media.
Accessibility Assessment of Community Care Resources Using Maximum-Equity Optimization of Supply Capacity Allocation
Authors: Tseng Ming-Hseng , Wu Hui-Ching
Published: January 2021

Equity in accessible healthcare is crucial for measuring health equity in community care policy. The most important objective of such a policy in Taiwan is empowering people and communities by improving health literacy and increasing access to healthcare resources. Using the nearest-neighbor two-step floating catchment area method, this study performed an accessibility assessment for community care resources before and after supply capacity optimization. For the target of maximum equity when allocating community care resources, taking maximum values, mean values and minimum values of the distances into consideration, three analytical allocation solutions for supply capability optimization were derived to further compare disparities in geographical accessibility. Three indicators, namely, the Gini coefficient, median minus mean and mean-squared error, were employed to assess the degree of optimization of geographical accessibility scores at the locations of the demand population and to determine the degree of geographic inequities in the allocation of community care resources. Our study proposed a method in which the minimum value of the distance is adopted as the approximate representation of distances between the service point and the locations of demand to determine the minimum value for supply capacity optimization. The study found that the method can effectively assess inequities in care resource allocation among urban and rural communities.
Residual Force Enhancement Is Present in Consecutive Post-Stretch Isometric Contractions of the Hamstrings during a Training Simulation
Authors: Chapman Neil D. , Whitting John W. , Broadbent Suzanne , Crowley-McHattan Zachary J. , Meir Rudi
Published: January 2021

Residual force enhancement (rFE) is observed when isometric force following an active stretch is elevated compared to an isometric contraction at corresponding muscle lengths. Acute rFE has been confirmed in vivo in upper and lower limb muscles. However, it is uncertain whether rFE persists using multiple, consecutive contractions as per a training simulation. Using the knee flexors, 10 recreationally active participants (seven males, three females; age 31.00 years ± 8.43 years) performed baseline isometric contractions at 150° knee flexion (180° representing terminal knee extension) of 50% maximal voluntary activation of semitendinosus. Participants performed post-stretch isometric (PS-ISO) contractions (three sets of 10 repetitions) starting at 90° knee extension with a joint rotation of 60° at 60°·s−1 at 50% maximal voluntary activation of semitendinosus. Baseline isometric torque and muscle activation were compared to PS-ISO torque and muscle activation across all 30 repetitions. Significant rFE was noted in all repetitions (37.8–77.74%), with no difference in torque between repetitions or sets. There was no difference in activation of semitendinosus or biceps femoris long-head between baseline and PS-ISO contractions in all repetitions (ST; baseline ISO = 0.095–1.000 ± 0.036–0.039 Mv, PS-ISO = 0.094–0.098 ± 0.033–0.038 and BFlh; baseline ISO = 0.068–0.075 ± 0.031–0.038 Mv). This is the first investigation to observe rFE during multiple, consecutive submaximal PS-ISO contractions. PS-ISO contractions have the potential to be used as a training stimulus.
Prediction of Trace Metal Distribution in a Tailings Impoundment Using an Integrated Geophysical and Geochemical Approach (Raibl Mine, Pb-Zn Alpine District, Northern Italy)
Authors: Barago Nicolò , Covelli Stefano , Mauri Mara , Oberti di Valnera Sara , Forte Emanuele
Published: January 2021

When mines are decommissioned, tailings piles can act as sources of contamination for decades or even centuries. Tailings, which usually contain high concentrations of metals and trace elements, can be reprocessed for a secondary recovery of valuable elements with an innovative approach to a circular economy. This study offers new results for tailings ponds characterisation and chemical content prediction based on an integrated geophysical-geochemical approach. The study of the Raibl Pb-Zn tailings impoundment was done using bulk chemical analysis on borehole samples, Electrical Resistivity Tomography surveys, and Ground Penetrating Radar measurements. We found valuable and statistically significant correlations between the electrical resistivity of the mining impoundments and the metal distribution, thus providing a practical opportunity to characterise large volumes of metal-bearing tailings. In particular, these results can be useful to aid in the development of environmental monitoring programs for remediation purposes or to implement economic secondary recovery plans.
Short-Term Effects of Air Pollution on Cardiovascular Hospitalizations in the Pisan Longitudinal Study
Authors: Fasola Salvatore , Maio Sara , Baldacci Sandra , La Grutta Stefania , Ferrante Giuliana , Forastiere Francesco , Stafoggia Massimo , Gariazzo Claudio , Silibello Camillo , Carlino Giuseppe , Viegi Giovanni ,   on behalf of the BEEP Collaborative Group
Published: January 2021

Air pollution effects on cardiovascular hospitalizations in small urban/suburban areas have been scantly investigated. Such effects were assessed among the participants in the analytical epidemiological survey carried out in Pisa and Cascina, Tuscany, Italy (2009–2011). Cardiovascular hospitalizations from 1585 subjects were followed up (2011–2015). Daily mean pollutant concentrations were estimated through random forests at 1 km (particulate matter: PM10, 2011–2015; PM2.5, 2013–2015) and 200 m (PM10, PM2.5, NO2, O3, 2013–2015) resolutions. Exposure effects were estimated using the case-crossover design and conditional logistic regression (odds ratio—OR—and 95% confidence interval—CI—for 10 μg/m3 increase; lag 0–6). During the period 2011–2015 (137 hospitalizations), a significant effect at lag 0 was observed for PM10 (OR = 1.137, CI: 1.023–1.264) at 1 km resolution. During the period 2013–2015 (69 hospitalizations), significant effects at lag 0 were observed for PM10 (OR = 1.268, CI: 1.085–1.483) and PM2.5 (OR = 1.273, CI: 1.053–1.540) at 1 km resolution, as well as for PM10 (OR = 1.365, CI: 1.103–1.690), PM2.5 (OR = 1.264, CI: 1.006–1.589) and NO2 (OR = 1.477, CI: 1.058–2.061) at 200 m resolution; significant effects were observed up to lag 2. Larger ORs were observed in males and in subjects reporting pre-existent cardiovascular/respiratory diseases. Combining analytical and routine epidemiological data with high-resolution pollutant estimates provides new insights on acute cardiovascular effects in the general population and in potentially susceptible subgroups living in small urban/suburban areas.
Parent Emigration, Physical Health and Related Risk and Preventive Factors of Children Left Behind: A Systematic Review of Literature
Authors: Račaitė Justina , Lindert Jutta , Antia Khatia , Winkler Volker , Sketerskienė Rita , Jakubauskienė Marija , Wulkau Linda , Šurkienė Genė
Published: January 2021

The aim of our study was to systematically review the literature on physical health and related consequences of internal and international parental migration on left-behind children (LBC). This review followed PRISMA guidelines. We searched the PubMed, Web of Science, Academic Search Complete, PsycINFO, and Cochrane databases and included studies reporting physical health-related outcomes of children affected by parental migration. The quality of the studies was assessed using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. We selected 34 publications from a total of 6061 search results. The study found that LBC suffer from poor physical health as compared with non-LBC. Physical health-related risk factors such as underweight, lower weight, stunted growth, unhealthy food preferences, lower physical activity, smoking, alcohol consumption, injuries, and incomplete vaccination tend to be more prevalent among LBC in China. Studies focussing on international migration argue that having migrant parents might be preventive for undernutrition. Overall, our study showed that children affected by internal or international migration tend to have similar physical health outcomes. Moreover, we identified a lack of evidence on international parental migration that may have influenced the overall impacts. Further studies addressing international migration would contribute to better understand the impacts of migration for LBC.
Versioning of 3D City Models for Municipality Applications: Needs, Obstacles and Recommendations
Authors: Eriksson Helen , Harrie Lars
Published: January 2021

The use of 3D city models is changing from visualization to complex use cases where they act as 3D base maps. This requires links to registers and continuous updating of the city models. Still, most models never change or are recreated instead of updated. This study identifies obstacles to version management of 3D city models and proposes recommendations to overcome them, with a main focus on the municipality perspective, foremost in the planning and building processes. As part of this study, we investigate whether national building registers can control the version management of 3D city models. A case study based on investigations of standards, interviews and a review of tools is presented. The study uses an architectural model divided into four layers: data collection, building theme, city model and application. All layers require changes when implementing a new versioning method: the data collection layer requires restructuring of technical solutions and work processes, storage of the national building register requires restructuring, versioning capabilities must be propagated to the city model layer, and tools at the application layer must handle temporal information better. Strong incentives for including versioning in 3D city models are essential, as substantial investment is required to implement versioning in all the layers. Only capabilities required by applications should be implemented, as the complexity grows with the number of versioning functionalities. One outcome of the study is a recommendation to link 3D city models more closely to building registers. This enables more complex use in, e.g., building permits and 3D cadastres, and authorities can fetch required (versioning) information directly from the city model layer.
In Silico Assessment of Class I Antiarrhythmic Drug Effects on Pitx2-Induced Atrial Fibrillation: Insights from Populations of Electrophysiological Models of Human Atrial Cells and Tissues
Authors: Bai Jieyun , Zhu Yijie , Lo Andy , Gao Meng , Lu Yaosheng , Zhao Jichao , Zhang Henggui
Published: January 2021

Electrical remodelling as a result of homeodomain transcription factor 2 (Pitx2)-dependent gene regulation was linked to atrial fibrillation (AF) and AF patients with single nucleotide polymorphisms at chromosome 4q25 responded favorably to class I antiarrhythmic drugs (AADs). The possible reasons behind this remain elusive. The purpose of this study was to assess the efficacy of the AADs disopyramide, quinidine, and propafenone on human atrial arrhythmias mediated by Pitx2-induced remodelling, from a single cell to the tissue level, using drug binding models with multi-channel pharmacology. Experimentally calibrated populations of human atrial action po-tential (AP) models in both sinus rhythm (SR) and Pitx2-induced AF conditions were constructed by using two distinct models to represent morphological subtypes of AP. Multi-channel pharmaco-logical effects of disopyramide, quinidine, and propafenone on ionic currents were considered. Simulated results showed that Pitx2-induced remodelling increased maximum upstroke velocity (dVdtmax), and decreased AP duration (APD), conduction velocity (CV), and wavelength (WL). At the concentrations tested in this study, these AADs decreased dVdtmax and CV and prolonged APD in the setting of Pitx2-induced AF. Our findings of alterations in WL indicated that disopyramide may be more effective against Pitx2-induced AF than propafenone and quinidine by prolonging WL.
Transcriptome Patterns of BRCA1- and BRCA2- Mutated Breast and Ovarian Cancers
Authors: Arakelyan Arsen , Melkonyan Ani , Hakobyan Siras , Boyarskih Uljana , Simonyan Arman , Nersisyan Lilit , Nikoghosyan Maria , Filipenko Maxim , Binder Hans
Published: January 2021

Mutations in the BRCA1 and BRCA2 genes are known risk factors and drivers of breast and ovarian cancers. So far, few studies have been focused on understanding the differences in transcriptome and functional landscapes associated with the disease (breast vs. ovarian cancers), gene (BRCA1 vs. BRCA2), and mutation type (germline vs. somatic). In this study, we were aimed at systemic evaluation of the association of BRCA1 and BRCA2 germline and somatic mutations with gene expression, disease clinical features, outcome, and treatment. We performed BRCA1/2 mutation centered RNA-seq data analysis of breast and ovarian cancers from the TCGA repository using transcriptome and phenotype “portrayal” with multi-layer self-organizing maps and functional annotation. The results revealed considerable differences in BRCA1- and BRCA2-dependent transcriptome landscapes in the studied cancers. Furthermore, our data indicated that somatic and germline mutations for both genes are characterized by deregulation of different biological functions and differential associations with phenotype characteristics and poly(ADP-ribose) polymerase (PARP)-inhibitor gene signatures. Overall, this study demonstrates considerable variation in transcriptomic landscapes of breast and ovarian cancers associated with the affected gene (BRCA1 vs. BRCA2), as well as the mutation type (somatic vs. germline). These results warrant further investigations with larger groups of mutation carriers aimed at refining the understanding of molecular mechanisms of breast and ovarian cancers.
Neurometals in the Pathogenesis of Prion Diseases
Authors: Kawahara Masahiro , Kato-Negishi Midori , Tanaka Ken-ichiro
Published: January 2021

Prion diseases are progressive and transmissive neurodegenerative diseases. The conformational conversion of normal cellular prion protein (PrPC) into abnormal pathogenic prion protein (PrPSc) is critical for its infection and pathogenesis. PrPC possesses the ability to bind to various neurometals, including copper, zinc, iron, and manganese. Moreover, increasing evidence suggests that PrPC plays essential roles in the maintenance of homeostasis of these neurometals in the synapse. In addition, trace metals are critical determinants of the conformational change and toxicity of PrPC. Here, we review our studies and other new findings that inform the current understanding of the links between trace elements and physiological functions of PrPC and the neurotoxicity of PrPSc.
Serotonin Pathway in Cancer
Authors: Balakrishna Pragathi , George Sagila , Hatoum Hassan , Mukherjee Sarbajit
Published: January 2021

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic monoamine produced from the essential amino acid tryptophan. Serotonin’s role as a neurotransmitter in the central nervous system and a motility mediator in the gastrointestinal tract has been well defined, and its function in tumorigenesis in various cancers (gliomas, carcinoids, and carcinomas) is being studied. Many studies have shown a potential stimulatory effect of serotonin on cancer cell proliferation, invasion, dissemination, and tumor angiogenesis. Although the underlying mechanism is complex, it is proposed that serotonin levels in the tumor and its interaction with specific receptor subtypes are associated with disease progression. This review article describes serotonin’s role in cancer pathogenesis and the utility of the serotonin pathway as a potential therapeutic target in cancer treatment. Octreotide, an inhibitor of serotonin release, is used in well-differentiated neuroendocrine cancers, and the tryptophan hydroxylase (TPH) inhibitor, telotristat, is currently being investigated in clinical trials to treat patients with metastatic neuroendocrine tumors and advanced cholangiocarcinoma. Several in vitro studies have shown the anticancer effect of 5-HT receptor antagonists in various cancers such as prostate cancer, breast cancer, urinary bladder, colorectal cancer, carcinoid, and small-cell lung cancer. More in vivo studies are needed to assess serotonin’s role in cancer and its potential use as an anticancer therapeutic target. Serotonin is also being evaluated for its immunoregulatory properties, and studies have shown its potential anti-inflammatory effect. Therefore, it would be of interest to explore the combination of serotonin antagonists with immunotherapy in the future.
Editorial to the Special Issue “Lipidomics and Neurodegenerative Diseases”
Authors: Calvano Cosima Damiana , Losito Ilario , Cataldi Tommaso
Published: January 2021

The contribution of dysregulation of lipid signaling and metabolism to neurodegenerative diseases including Alzheimer’s and Parkinson’s is the focus of this special issue. Here, the matter of three reviews and one research article is summarized.