bluuebunny/crossref_metadata_2025 huggingface dataset:
DEMANDA ENERGÉTICA NA CONSTRUÇÃO DE GALPÃO PARA FRANGOS DE CORTE MODELO DARKHOUSE
Authors: Mattioli Matheus Campos , Campos Alessandro Torres , Ferreira Jacqueline Cardoso , Veloso Alessandro Vieira , Abreu Lucas Henrique Pedrozo
Published: January 2019

Notadamente, os avanços tecnológicos buscados pelo setor de construções rurais promovem ganhos em conforto e bem-estar animal, garantindo aumentos em produtividade. Neste sentido, o presente trabalho objetivou avaliar a demanda energética, de maneira detalhada, para implantação de um galpão aviário tipo Darkhouse, cuja atividade produtiva constitui da criação de frangos de corte, identificando as quantidades dos principais componentes e serviços necessários à construção. Foram considerados todos os materiais e serviços inerentes a cada uma das etapas de construção, onde os totais quantificados foram convertidos em unidades de energia, identificando aqueles de maior requerimento energético. Dentre os materiais de construção utilizados, destaca-se o aço, que correspondeu a 26,19% da energia investida na instalação. Neste sentido, o cimento também ocupou posição de destaque durante a quantificação dos materiais de construção, representando 8,47%. A energia depreendida durante a fase de limpeza e movimentação de solo representou 48,52% do total investido, devido, principalmente, ao grande volume de solo movimentado. A obra consumiu um total de 3.293.064,77 MJ de energia, distribuídos entre serviços e materiais. O coeficiente energético específico para cada metro quadrado do aviário foi de 1.219,65 MJ m-2. Poucos trabalhos foram encontrados na literatura, principalmente brasileira, abordando os gastos energéticos em estruturas destinadas à criação de animais e da energia presente em materiais e serviços. Desta forma, os resultados obtidos no presente trabalho visam fornecer dados específicos e incentivar pesquisadores no que tange às análises energéticas.
ÁGUA RESIDUÁRIA DE LATICÍNIO EM CODIGESTÃO COM DEJETOS DE BOVINOS LEITEIROS
Authors: Fernandes Aline , Branco Paula Maria Pilotto , Cangani Max Ternero , Júnior Jorge De Lucas
Published: January 2019

O trabalho objetivou avaliar o efeito da codigestão de água residuária de laticínio com dejetos bovinos em biodigestores do tipo batelada sobre a produção de biogás. Avaliou-se o efeito da inclusão de água residuária de laticínio (ARL): 0% de ARL, 50% de ARL, 77,5 % de ARL, 100% de ARL com 8% de sólidos totais (ST) e tratamento com 100% de ARL com 1,8% de sólidos totais. Para análise dos dados considerou-se um delineamento inteiramente casualizado, utilizando-se o programa SAS® com nível de significância de 5%. Para a variável analisada, produção total de biogás, houve resposta da substituição da agua potável pela agua residuária de laticínio com 8% de ST no volume de biogás produzido, apresentando maiores médias quando comparado ao tratamento com 1,8 de ST. Para as variáveis de potenciais de produção exceto pela produção por kg de sólidos voláteis reduzidos houve diferença significativa para o tratamento com 50% de ARL e ST 8%. O aproveitamento da água residuária para compor substrato em codigestão com dejetos bovinos leiteiros apresentou condições favoráveis de produção de biogás.
DIAGNÓSTICO AMBIENTAL DA BACIA HIDROGRÁFICA DO RIBEIRÃO PEDERNEIRAS, PEDERNEIRAS/SP
Authors: Garcia Yara Manfrin , Gonçalves Aline Kuramoto , Tagliarini Felipe De Souza Nogueira , Campos Sergio , Spadotto Anselmo José
Published: January 2019

Esta pesquisa teve como objetivo realizar o diagnóstico ambiental do meio físico da bacia hidrográfica do ribeirão Pederneiras, localizada nos municípios de Agudos e Pederneiras, no estado de São Paulo. Os procedimentos metodológicos foram baseados na estruturação de um banco de dados digital em ambiente de Sistema de Informação Geográfica visando à elaboração, atualização, interação e confecção dos mapas. A bacia hidrográfica do ribeirão Pederneiras possui uma área de 14918,28 ha e perímetro de 67,46 km, sendo considerada de 4ª ordem e baixa declividade. Com base nos resultados pode-se afirmar que a área é praticamente agrícola, dentre as doze classes de uso e ocupação do solo, a cana-de-açúcar é a cultura predominante com 6286,22 ha, seguido pelo reflorestamento com 5605,56 ha e, mesmo assim, merece destaque a área urbana que é de 1117,67 ha. Quanto as Áreas de Preservação Permanente, estas vêm sendo ocupadas inadequadamente e tem causado diversos problemas ambientais como, por exemplo, enchentes, assoreamentos e poluição dos cursos d’água, impermeabilização do solo, entre outros. Desta forma, com base nos resultados expostos, conclui-se a necessidade de medidas minimizadoras de problemas ambientais para a área urbana e rural e que tenham como base planos de ações e de controle desenvolvidos para nortear a aplicabilidade e fiscalização nessas áreas. Pretende-se que esse diagnóstico ambiental possa subsidiar o planejamento desta bacia hidrográfica pelo poder público e órgãos gestores.
Ticari Dışa Açıklık ve Ekonomik Büyüme Arasındaki İlişkinin Analizi: Türkiye Örneği
Authors: EREN Mehmet Vahit , ERGİN-ÜNAL Ayşe
Published: January 2019

Bu çalışmanın amacı, ticari dışa açıklık ile ekonomik büyüme arasındaki ilişkiyi, Türkiye ekonomisi için 1960-2016 yıllarına ait yıllık verilerle ekonometrik açıdan incelemektir. Bu amaçla, analizde ihracat ile ithalatın toplamının milli gelire oranı ve reel kişi başına düşen gelir değişkenleri kullanılmıştır. Ticari dışa açıklık ile ekonomik büyüme arasındaki ilişkilerin analizi için Engle-Granger ve Gregory-Hansen eşbütünleşme testleri ve nedensellik ilişkisini belirlemek için Granger nedensellik testi yapılmıştır. Yapılan test sonuçlarında, değişkenler arasında uzun dönemli bir ilişki tespit edilememiş, çift yönlü nedensellik ilişkisi bulunmuştur.
Forzani & MacPhail Colon Cancer Screening Centre Biorepository - Blood Collection, Processing & Storage Standard Operating Procedure v1
Authors: Town Susanna
Published: January 2019

This Standard Operating Procedure (SOP) provides clear instructions on the collection and handling of blood samples for storage at the Colon Cancer Screening Centre Biorepository, to ensure quality specimens and professional care of the human subject. Blood samples are drawn from participants that have been through the informed consent process and agreed to participate in the CCSC Biorepository.
A new concept of superelevation in magnetic levitation – prodynamic
Authors: Jacob Angelo , Monteiro Nuno
Published: January 2019

Background: The topic of Magnetic Levitation systems, in terms of land mass transport, have created high expectations compared to aviation and also to the high speed railway industry. This new concept comes to revolutionize the terrestrial mass transport, in both the speeds and the subject of friction. Magnetic levitation solves the issue of attrition between material contact and as such may also be an opportunity to solve the question of constant physical superelevation.

Aim: Precisely that point of superelevation coupled with magnetic levitation, eliminating the rigid physical structures to laterally lift the vehicle in a curve. Current magnetic levitation systems do not address this issue of dynamic superelevation. It’s exposed an improvement technology which is a theoretical possibility of a track through a new magnetic line can apply necessary rotation to the vehicle in curve and adjust its rotation according to the speed that vehicle moves.

Methods: In order to make this system to work it is suggested the introduction of a magnetic field in the new line, which will allow the vehicle to rotate in curves and will negate the need of the conventional static superelevation.

This study appeared as a result of an investigation of a master's thesis in civil engineering at ISEP, where the participants created the concept of dynamic superelevation in the context of magnetic levitation. The project was applied to the reformulation of an existing railway network. The study base of this model resulted from a broad survey of current magnetic levitation systems. Then came the idea of creating a third dynamic magnetic field to operate the curved superelevation.

Results: The result of the study was the creation of a new "monorail" system of simple and geometrically constant structure. The new line has the advantage of providing a simple and constant geometry, facilitating the manufacture, assembly and thus making it much more economical compared to the current systems. The cross-section allows the vehicle to fit perfectly and with the creation of rotating magnetic fields, the vehicle can be turned to both sides, at the required inclination, according the speed. With this new concept called ProDynamic, the geometry design in plan is totally independent of the speed practiced by the vehicle, where it can travel in curve at different speeds, but with the same lateral no-compensated acceleration, without detriment of passenger comfort.

Conclusion: Combining existing systems with this new concept, it is possible to create a total freedom in curves and superelevation, which will provide a maximum comfort and significant construction savings. There is therefore no longer a problem of deficiency or excess cant, as currently exists on railways. The advantage in the ProDynamic system is that it is possible to greatly reduce or even eliminate the lateral no-compensated acceleration.
1821 Yunan İsyanı Sırasında Selanik Sancağı ve İsyana Karşı Alınan Önlemler
Authors: AYDIN H. Veli
Published: January 2019

Aleksander İpsilantis liderliğinde 1821’de Eflak ve Boğdan’da başlayıp, kısa sürede Rum nüfusun yoğun olarak yaşadığı ve görece Osmanlı kuvvetlerinin müdahalesinin zor olduğu Mora ve Akdeniz adaları gibi bölgelere yayılan Yunan isyanı, aynı zamanda Rumeli’deki önemli vilayetlerden biri olan Selanik’e de sıçradı. Vilayet merkezi ve sancağında bağlı Halkidiki yarımadası, Taşoz adası ve Ağustos kazasındaki isyan Emmanuel Papas liderliğinde ve Ortodoks dünyasının önemli ruhani merkezlerinden biri olan Aynaroz yarım adasındaki manastırlardan yönetildi ve yaklaşık bir yıl sürdü. Bu çalışma Selanik sancağındaki isyanın çıkışı, yayılışı ve Osmanlı Devleti’nin ve yerel yöneticilerin isyan sırası ve sonrasında uyguladıkları politikaları ve aldıkları önlemleri Osmanlı arşiv belgeleri ve Yunanca kaynaklardan yararlanarak incelemekte, isyanın bölgesel ölçekte hangi yöntemlerle bastırıldığını ve isyan sonrası Rum reayasına karşı devletin politikalarını ele almakta ve ihtilâle yönelik çalışmalara bölgesel uygulamalar bağlamında bir katkı yapmayı amaçlamaktadır. Ayrıca sancak yöneticilerinin isyan süresince sürekli merkez ile iletişim içinde olduğunu, merkezden gelen emirleri uygulamaya çalıştığını ve merkezi bir plan çerçevesinde isyanla mücadele ettiğini savunmaktadır.
DEVELOPMENT OF AN EFFECTIVE MONITORING SYSTEM OF ACUTE FATAL POISONING IN SBIH MR “BUREAU OF FORENSIC MEDICAL EXAMINATION”
Authors: Maksimov A. V. , Kuchuk S. A.
Published: January 2019

The article presents the experience of the development and implementation of monitoring system of acute fatal poisoning by chemical substances in the practical activities of SBIH MR «Bureau of FME». The goals, main functions, components, scope of practical application and monitoring capabilities are revealed.
ABOUT CARRYING OUT PRIMARY SPECIALIZED ACCREDITATION OF SPECIALIST IN SPECIALITY “FORENSIC MEDICAL EXAMINATION”
Authors: Lysenko O. V. , Tarasov N. V. , Maksimov A. V. , Kuchuk S. A.
Published: January 2019

The article identifies the key stages of the primary specialized accreditation of a specialist in speciality “Forensic medical examination”.
FORENSIC MEDICINE OF PEOPLE’S REPUBLIC OF CHINA, FROM ITS ORIGINS TO THE PRESENT DAY
Authors: Klevno V. A. , Nazarov Yu. V.
Published: January 2019

In the publication, based on the book «the History of forensic medicine» under the editorship of doctor of medical sciences, professor Burkhard Madea, provides basic information about forensic medicine in the People’s Republic of China, details the history of its origin, the path and the complexity of its development, shows the current organization of services, the principles of training of forensic experts. The achievements of Chinese forensic medicine, both in the past and in the present, are noted.
Formação para municípios saudáveis: trajetória, experiência e desafios para a Rede Pernambucana de municípios saudáveis
Authors: Sá Ronice Maria Pereira Franco de , Freire Socorro Machado , Salles Rosane Senna
Published: January 2019

O artigo trata da trajetória da Rede Pernambucana de Municípios Saudáveis (RPMS), sua experiência e desafios específicos para a formação temática que realiza desde 2004, tendo como pano de fundo a reemergência do ideário das cidades saudáveis no contexto mundial, após o Encontro dos Prefeitos acontecido em Xangai, em 2016. São descritos os cursos principais, público-alvo e conteúdo programático. Reflexões teórico-conceituais são realizadas sobre a caminhada da RPMS. Em um novo cenário, deve-se considerar a agenda 2030 e os objetivos do desenvolvimento sustentável, um dos quais trata sobre o tema de municípios, cidades e comunidades saudáveis (MCCS).  Apresenta-se o guia da Organização Panamericana de Saúde para a implementação da Declaração de Xangai e discute-se as possibilidades de adoção desse guia na nova formação proposta para a RPMS. Ressalta-se, ainda, os novos desafios que surgiram no âmbito da virtualização, da necessidade de mudar abordagem e conceito sobre promoção da saúde, da constatação do não-lugar e da mixofobia e aponta-se que esses temas emergentes precisam ser enfrentados na formação que a RPMS oferece.
O regramento ambiental de parcelamento do solo como instrumento para a cidade saudável no estado de São Paulo
Authors: Agujaro Livia Fernanda , Collaço Juliana Fontes Lima , Pinto Adonai Guimarães
Published: January 2019

As Áreas Verdes Urbanas, assim definidas em lei, podem trazer benefícios em termos de qualidade de vida da população pelos serviços ecossistêmicos associados. Em consonância com a Política Nacional de Promoção da Saúde cabe ao poder público apoiar o desenvolvimento de espaços de produção social e ambientes saudáveis, favoráveis ao desenvolvimento humano e ao bem-viver; contribuindo para formação de agendas de pro-moção da saúde. A cidade saudável deve prover qualidade ambiental a seus habitantes, com o zoneamento prevendo equipamentos urbanos que visem aos serviços ambientais e que preservem as funções ecossistêmicas do ambiente. A tendência de implantação de grandes loteamentos fechados, uma realidade frequente no Estado de São Paulo, molda a configuração espacial urbana, enclausurando áreas verdes públicas, impedindo o uso destas pela população em geral e comprometendo suas funções ambientais. Este artigo pretende criar uma reflexão sobre a realidade do licenciamento ambiental de loteamentos urbanos e aspectos legais no Estado de São Paulo que podem impactar na saúde ambiental no que se refere às áreas verdes, bem como avaliar a relação da população com estes espaços, tendo como base vivências na análise técnica para aprovação de projetos habitacionais dos autores, o que contribuirá para a construção de espaços públicos saudáveis mais participativos e integrativos.
Editorial L&E 12 (4) 2018. Cidade saudável, suas estratégias e desafios
Authors: Argollo Ferrão André Munhoz de , Sperandio Ana Maria Girotti
Published: January 2019

Chegamos ao final de mais um ano oferecendo ao público da Labor & Engenho o último número seriado deste prestigioso periódico eletrônico, já consagrado em sua área de abrangência — o L&E, v.12, n.4, out./dez., 2018. A partir do volume 13, em 2019, a revista Labor & Engenho passará a adotar o sistema de Publicação Contínua (PC), o que resultará em um fluxo contínuo de edição e publicação de artigos submetidos tão logo sejam aprovados em processo contínuo de avaliação/editoração, independentemente dos 4 marcos mensais até então estabelecidos ao longo do ano com os números 1 (jan./mar.), 2 (abr./jun.), 3 (jul./set.) e 4 (out./dez.), abolindo, desta forma, a fragmentação em fascículos — ou números — trimestrais. Trata-se de uma tendência de otimização do processo editorial das revistas eletrônicas em todo o mundo.[...] Continue lendo o PDF completo...
Propriedade intelectual na pós-graduação das universidades federais do nordeste: indicadores bibliométricos
Authors: Vasconcelos Jandira Reis , Santos João Antonio Belmino dos
Published: January 2019

A análise da produção do conhecimento científico, através da bibliometria, permite avaliar o perfil de área específica. Neste sentido, este artigo apresenta os indicadores bibliométricos dos Programas de Pós-Graduação da região Nordeste que pesquisam sobre Propriedade Intelectual. Esta pesquisa classifica-se como exploratória, com abordagens quantitativa e qualitativa, tendo como campo de estudo: Universidade Federal da Bahia (UFBA), Universidade Federal de Sergipe (UFS), Universidade Federal de Alagoas (UFAL), Universidade Federal de Pernambuco (UFPE), Universidade Federal da Paraíba (UFPB), Universidade Federal do Ceará (UFC), Universidade Federal do Maranhão (UFMA), Universidade Federal do Piauí (UFPI), Universidade Federal do Rio Grande do Norte (UFRN). A coleta de dados foi feita na Base de Dados de Teses e Dissertações da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) e nos Repositórios Institucionais das instituições pesquisadas. Como estratégia de busca, utilizou-se o termo “Propriedade Intelectual”, que permitiu encontrar 4 (quatro) teses e 34 dissertações. Para organização dos dados foram utilizados os softwares Excel® e Word Art®. Com os resultados, foi possível identificar os Programas de Pós-Graduação que desenvolveram pesquisas em Propriedade Intelectual, as temáticas abordadas e as palavras-chave mais recorrentes. Dessa forma, foi viável traçar um panorama dos aspectos da pesquisa em Propriedade Intelectual através da construção de indicadores bibliométricos.
ANALISIS SISTEM PENGENDALIAN BAHAYA CONVEYOR BELERANG DI PELABUHAN PT. PETROKIMIA GRESIK
Authors: Saputra Dewangga Aji
Published: January 2019

A technical and administrative control effort should be undertaken to prevent or reduce the impact of workplace accidents. Workplace accidents can be caused by unsafe human behavior and unsafe working environment conditions. This study has a general purpose for analyzing the sulfur conveyor hazard control system in PT Petrokimia Gresik. This research is observational, where as according to the way of data taking and timing of data retrieval is included in cross sectional study. The object of this research is the concession hazard control system of PT Petrokimia Gresik. In this research, I use descriptive analysis technique. The data used in this study is the primary data obtained from observations and interviews and secondary data obtained from corporate documents. The time of this research was conducted on April 20, 2015 until May 20, 2015. The result of the analysis on sulfur conveyor hazard control system in general is good. Lockout and tag out already have the tools and procedures but in its application still less and need to be improved. Emergency stop and emergency pull cord have less than 25% damage thus can be categorized well. To safeguard the fire hazard is properly installed and has good physical condition. For conveyor safety is in accordance with the standard nf en standards 294. For safety signs should be added. Administrative control measures are well implemented. Companies are advised to improve safety control efforts as there are still some need to be upgraded to either category.Keywords: analysis, control, conveyor, hazard
APLIKASI ALOFAN DALAM TANAH ANDISOL SEBAGAI ADSORBEN UNTUK MENURUNKAN BAKTERI Coliform LIMBAH CAIR DOMESTIK
Authors: Rois Ibnu , Pranoto Pranoto , Sunarto Sunarto
Published: January 2019

Research on allophane has been done as an adsorbent to decrease MPN Coliform in domestic wastewater. The purpose of this study was to look for natural adsorbent materials that can be used to decrease MPN Coliform. Natural allophane was identified from andisol soil by pH analysis of NaF, FTIR, XRD, and SAA. The result of the analysis showed that there was allophane on andisol soil with pH 11,73. The diameter of empty space or alloy pores of 5 nm with a hole/pore size of 0.5 nm. Testing of MPN Coliform is done by method of Most Probable Number (MPN) variety 5: 5: 5. Based on the result of the research, allophane adsorbent can decrease MPN Coliform by 60.9%.
RESPON PERTUMBUHAN DAN PRODUKTIVITAS KELAPA SAWIT (Elaeis Guineensis Jacquin) TERHADAP KEDALAMAN DAN BOBOT BAHAN ORGANIK PENUTUP BIOPORI PADA TANAH PODSOLIK MERAH KUNING
Authors: Battong Umar , Wahdah Raihani , Rusmayadi Gusti
Published: January 2019

This study aims to determine the effect of bokashi and biopori depth treatment on growth and production of oil palm. The study was conducted at Long Gelang Paser Regency in August 2017 - January 2018 using a randomized block design with two factors. The first factor is the depth of biopori with depth: 50, 75, and 100 cm and the second factor is bokashi weight with level: 4, 5 and 6 tons per hectare with three replicates, highest weight of TBS obtained at 75 cm biopori depth, obtained at a depth of 100 cm biopori with 6 ton per hectare of bokashi, the highest soil N content was obtained at 50 cm depth with treatment of 6 tons per hectare bokashi, the highest groundwater content was obtained at 75 cm biopori depth with bokashi 4 tons per hectare
Thermal Expansion Model of Cement paste and Concrete Considering Micro-Structural Changes under Elevated Temperature
Authors: Lee Jaesung , Xi Yunping , Yang Seungcho
Published: January 2019

The expansion of concrete subjected to extreme elevated temperature is linked with intricate micro-structural variations, such as the transformation of the constituent phases. This study proposes a model to predict the thermal expansion of cement paste and concrete considering micro-structural changes under elevated temperatures ranging from 20°C to 800°C. The model presented can consider characteristics of various aggregates in the calculation of thermal expansion for concrete. The model is a combination of a multi-scale stoichiometric model and a multi-scale composite model. At the cement paste level, the model satisfactorily predicted a test result. At concrete level, upper bounds from the model were matched relatively well with test results by previous researcher. If the mechanical properties, such as elastic modulus (E), Poisson’s ratio (ν), and thermal deformation, of the aggregates used in concrete are given, it is likely that the model will reasonably predict experimental results.
Efficacy Evaluation of Skin Care ProductsUsing PhabrOmeter
Authors: Pan Ning , Lum Melissa , Tran Brian
Published: January 2019

Current instrumental technology in evaluating performance of skin care creams is still rather limited and there are no industrial standard testing equipment, method and performance specifications for it.  In this paper, we report our attempt in using an instrument called PhabrOmeter for this purpose. PhabrOmeter is a commercialized instrument for sensory performance evaluation of textiles, leather, paper and nonwoven and has been designated by American Association of Textile Chemists and Colorists (AATCC) as a standard test method for textiles, AATCC TM 202 in 2013.    By adopting artificial skin samples treated with skin care creams, we have developed a procedure to apply this instrument for evaluation of skin care creams from sample preparation, measurement to data analysis and interpretation. The results using commercial skin care creams to demonstrate the feasibility and advantages of this instrument are provided.
Sinergi Kegiatan Desa Mandiri Benih dan Kawasan Mandiri Benih untuk Mewujudkan Swasembada Benih
Authors: Darwis Valeriana
Published: January 2019

Rice seed determines successful rice farming. Adopting quality seed will improve farm yield. Rice seed procurement programs implemented by Ministry of Agriculture (MoA) among others are Seed Self-Reliance Region Model coordinated by IAARD and Seed Self-Reliance Village managed by Directorate General of Food Crops. This paper aims to synthesize those two seed procurement programs into one program called as Seed Producer Center Village. Both programs have similarities, i.e. (a) both programs were carried out by MoA, (b) programs implementation involve Provincial and Regional Agriculture Offices, BPTP/UPBS, and BPSBTPH, and (c) encouraging seed growers to become seed producers. Requirements to integrate both programs are: (i) duties coordination of each involved agency; (ii) selection of seed growers to participate in the program; (iii) seed growers training carried out by BPSBTPH/UPBS, (iv) production inputs purchase prior to planting season, and (v) the government buys the seed produced in the program and distribute it to the rice production enhancement programs.

 

Abstrak

Benih menjadi penentu awal keberhasilan dalam budidaya tanaman. Penggunaan benih bermutu akan meningkatkan produktivitas. Program pengadaan benih yang sudah dilaksanakan oleh Kementerian Pertanian antara lain adalah Model Kawasan Mandiri Benih di bawah koordinasi Balitbangtan dan Desa Mandiri Benih di bawah koordinasi Direktorat Jenderal Tanaman Pangan. Tulisan ini menguraikan alasan dan cara mensinergikan dua program pengadaan benih ke dalam satu program dengan nama Desa Sentra Produsen Benih. Kedua program memiliki banyak kesamaan di antaranya adalah: (a) dilaksanakan dalam satu kementerian, (b) pada pelaksanaan di lapang melibatkan instansi yang sama yaitu Dinas Pertanian Provinsi dan Kabupaten, BPTP/UPBS, BPSBTPH, dan (c) menjadikan penangkar sebagai produsen benih. Dalam pelaksanaannya, sinergi kedua program membutuhkan: (i) koordinasi dan tugas masing-masing lembaga yang terlibat; (ii) pemilihan penangkar yang mau dibina; (iii) pembinaan penangkar langsung oleh BPSBTPH/UPBS, (iv) pengadaan sarana produksi sebelum masuk musim tanam, dan (v) pemerintah ikut membeli benih yang dihasilkan oleh penangkar dan mengembalikan benih tersebut ke petani sekitarnya dalam bentuk program pemerintah lainnya yang berhubungan dengan benih.
Multiloop functional renormalization group for the two-dimensional Hubbard model: Loop convergence of the response functions
Authors: Tagliavini Agnese , Hille Cornelia , Kugler Fabian , Andergassen Sabine , Toschi Alessandro , Honerkamp Carsten
Published: January 2019

We present a functional renormalization group (fRG) study of the two
dimensional Hubbard model, performed with an algorithmic implementation
which lifts some of the common approximations made in fRG calculations.
In particular, in our fRG flow; (i) we take explicitly into account the
momentum and the frequency dependence of the vertex functions; (ii) we
include the feedback effect of the self-energy; (iii) we implement the
recently introduced multiloop extension which allows us to sum up
all the diagrams of the parquet approximation with
their exact weight. Due to its iterative structure based on successive
one-loop computations, the loop convergence of the fRG results can be
obtained with an affordable numerical effort. In particular, focusing on
the analysis of the physical response functions, we show that the
results become independent from the chosen cutoff
scheme and from the way the fRG susceptibilities are computed, i.e.,
either through flowing couplings to external fields, or through a
“post-processing” contraction of the interaction vertex at the end of
the flow. The presented substantial refinement of fRG-based computation
schemes paves a promising route towards future quantitative fRG analyses
of more challenging systems and/or parameter regimes.
Enhancement of rhizocompetence in pathogenic bacteria removal of a constructed wetland system
Authors: Ben Saad Marwa , Ben Said Myriam , Sanz-Sáez Isabel , Sánchez Olga , Morató Jordi , Bousselmi Latifa , Ghrabi Ahmed
Published: January 2019

The main goal of the present study was to enhance the rhizobacterium potential in a horizontal subsurface flow constructed wetland system planted with Phragmites australis, through environmentally friendly biological approaches. The bioinoculation of antagonist bacteria has been used to promote higher rhizosphere competence and improve pathogenic bacteria removal from wastewater. The experiment was performed both with single and sequential bioinoculation. The results showed that strain PFH1 played an active role in pathogenic bacteria removal, remarkably improving inactivation kinetics of the pathogenic tested bacterium Salmonella typhi in the plant rhizosphere. The single bioinoculation of selected bacteria into the rhizosphere of P. australis improved the kinetics of S. typhi inactivation by approximately 1 U-Log10 (N/N0) (N is the number of viable cultured bacteria at time t, N0 is the number of viable and cultivable bacteria at time t0) compared to the control. By a series of multi-bioinoculations, the enhancement of pathogenic bacteria reduction compared to the inhibition rate in the pilot-scale control was of 2 U-Log10(N/N0). These findings suggested that this strain represents a promising candidate to enhance water purification in constructed wetlands.
Design and start-up of a constructed wetland as tertiary treatment for landfill leachates
Authors: Coppini Ester , Palli Laura , Antal Alexandra , Del Bubba Massimo , Miceli Elisangela , Fani Renato , Fibbi Donatella
Published: January 2019

In this paper, the design and start-up of a constructed wetland (CW) for the tertiary treatment of landfill leachates is presented. The flux is characterized by high salinity, high concentration of nitrogen (almost completely in the form of nitrate) and a biochemical oxygen demand (BOD)/chemical oxygen demand (COD) ratio close to zero. The CW pilot plant suffered from mechanical and hydraulic malfunctions which led to an uneven growth of plants inside the tanks. Despite this, COD has been reduced in the range of 0–30%, reduced forms of N (ammonia and nitrite) are also oxidized and removed by 50–80% and 20–26% on average. Considering the low number of plants and the loading rate, CW pilot plant allowed to remove more than 16 kg of COD, leading to a specific removal of 10 gCOD/d · m2. Moreover, bacterial communities associated to plants were isolated and analyzed in order to evaluate the influence of such communities on phytoremediation. Bulk soil registered the lowest bacterial titers, while plant compartments and rhizospheric soil showed to be more suitable for bacterial colonization. Twenty-five different bacterial genera were observed among the analyzed isolates, with the predominance of Pseudomonas genus.
Influence of Calcium Ions on the Thermal Characteristics of α-amylase from Thermophilic Anoxybacillus sp. GXS-BL
Authors: Liao Si-Ming , Liang Ge , Zhu Jing , Lu Bo , Peng Li-Xin , Wang Qing-Yan , Wei Yu-Tuo , Zhou Guo-Ping , Huang Ri-Bo
Published: January 2019

Background: α-Amylases are starch-degrading enzymes and used widely, the study on thermostability of α-amylase is a central requirement for its application in life science and biotechnology.  Objective: In this article, our motivation is to study how the effect of Ca2+ ions on the structure and thermal characterization of α-amylase (AGXA) from thermophilic Anoxybacillus sp.GXS-BL.  Methods: α-Amylase activity was assayed with soluble starch as the substrate, and the amount of sugar released was determined by DNS method. For AGXA with calcium ions and without calcium ions, optimum temperature (Topt), half-inactivation temperature (T50) and thermal inactivation (halflife, t1/2) was evaluated. The thermal denaturation of the enzymes was determined by DSC and CD methods. 3D structure of AGXA was homology modeled with α-amylase (5A2A) as the template.  Results: With calcium ions, the values of Topt, T50, t1/2, Tm and ΔH in AGXA were significantly higher than those of AGXA without calcium ions, showing calcium ions had stabilizing effects on α-amylase structure with the increased temperature. Based on DSC measurements AGXA underwent thermal denaturation by adopting two-state irreversible unfolding processes. Based on the CD spectra, AGXA without calcium ions exhibited two transition states upon unfolding, including α- helical contents increasing, and the transition from α-helices to β-sheet structures, which was obviously different in AGXA with Ca2+ ions, and up to 4 Ca2+ ions were located on the inter-domain or intra-domain regions according to the modeling structure.  Conclusion: These results reveal that Ca2+ ions have pronounced influences on the thermostability of AGXA structure.
Nonalcoholic Fatty Liver Disease in Patients with Polycystic Ovary Syndrome
Authors: Macut Djuro , Bjekić-Macut Jelica , Livadas Sarantis , Stanojlović Olivera , Hrnčić Dragan , Rašić-Marković Aleksandra , Milutinović Danijela V. , Mladenović Violeta , Andrić Zoran
Published: January 2019

Polycystic ovary syndrome (PCOS) is the most common endocrine disease in women during the
reproductive period. True PCOS phenotype is prone to develop metabolic consequences during life. Obese PCOS
women with insulin resistance are carrying a risk for developing type 2 diabetes, and influencing liver function by
generating liver steatosis and nonalcoholic fatty liver disease (NAFLD). Moreover, serum testosterone of over 3
nmol/L is associated with at least two-fold higher risk for the development of NAFLD in PCOS women. Numerous
genes involved in the pathogenesis of hyperandrogenism, insulin resistance and inflammation are associated with
the development of NAFLD in PCOS women. Liver biopsy is not considered as the first line procedure for the
diagnosis of liver damage in a prevalent condition as PCOS. Therefore, simple and reliable surrogate markers as
serum aminotransferases levels or surrogate indexes (i.e. fatty liver index and NAFLD-fatty liver score) could be
used for the assessment of fatty liver in PCOS women. First line therapeutic approach for NAFLD in PCOS includes
a change in lifestyle that implies dietary regiment and physical activity but without well-defined protocols.
Second line therapy considers addition of drugs on the established lifestyle change. Metformin remains the drug of
choice for reduction of insulin resistance and liver enzymes level. Liraglutide, glucagon-like peptide-1 receptor
agonists, showed favorable effects on the reduction of liver fat content and visceral adipose tissue in overweight
women with PCOS. Current review analyzes the impact of metabolic risk factors, diagnostic approach and management
options on NAFLD in women with PCOS.
New Perspectives on the Efficacy of Gallic Acid in Cosmetics & Nanocosmeceuticals
Authors: Khan Barkat Ali , Mahmood Tariq , Menaa Farid , Shahzad Yasser , Yousaf Abid Mehmood , Hussain Talib , Ray Sidhartha D.
Published: January 2019

Background:

Gallic acid (GA-3,4,5-trihydroxybenzoic acid), a phenolic phytochemical, is a
ubiquitous secondary metabolite found in most plants, with appreciable concentrations in grapes seed, rose flowers,
sumac, oak and witch hazel. GA often results from the hydrolysis of terpenes and the polyphenol tannic acid.

Applications:

It exhibits powerful antioxidant, anti-inflammatory, antimicrobial, and anti-cancer activities. Most
intriguing benefit has been reported to be on the skin. Due to these beneficial properties, GA and its derivatives
(e.g. lipid-soluble phenols such as synthetic gallic esters aka gallates) have been extensively used as an adjuvant
in a number of therapeutic formulations, as a substitute of hydrocortisone in children with atopic dermatitis (AD)
and other skin conditions (hyperpigmentation, wound healing), and as a cosmetic ingredient. GA has a USFDA
GRAS status (generally recognized as safe), exhibiting fairly low systemic toxicity and associated mortality at
acute doses in many experimental models. Despite anti-skin aging benefits obtained with relatively safe GA formulations,
few cases of gallate-induced skin allergic have been reported in humans. Therefore, approaches to
improve the bioavailability and biodegradability of this poor-water soluble and non-biodegradable phenolic compound
are warranted.

Purpose:

This review has focused on the recently reported biological activities pertaining to the skin as well as
the pharmacological properties of GA and its derivatives with special emphasis on its use in (nano-) cosmetic
formulations. Since this is an evolving area of research, an adequate emphasis has been placed upon advantages
and disadvantages of various nanoformulations.
Topical Drug Delivery of Anti-infectives Employing Lipid-Based Nanocarriers: Dermatokinetics as an Important Tool
Authors: Thakur Kanika , Sharma Gajanand , Singh Bhupindar , Katare Om Prakash
Published: January 2019

Background:

The therapeutic approaches for the management of topical infections have always been a difficult approach due to lack of efficacy of conventional topical formulations, high frequency of topical applications and non-patient compliance. The major challenge in the management of topical infections lies in antibiotic resistance which leads to severe complications and hospitalizations resulting in economic burden and high mortality rates.

Methods:

Topical delivery employing lipid-based carriers has been a promising strategy to overcome the challenges of poor skin permeation and retention along with large doses which need to be administered systemically. The use of lipid-based delivery systems is a promising strategy for the effective topical delivery of antibiotics and overcoming drug-resistant strains in the skin. The major systems include transfersomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, microemulsion and nanoemulsion as the most promising drug delivery approaches to treat infectious disorders. The main advantages of these systems include lipid bilayer structure which mimics the cell membrane and can fuse with infectious microbes. The numerous advantages associated with nanocarriers like enhanced efficacy, improvement in bioavailability, controlled drug release and ability to target the desired infectious pathogen have made these carriers successful.

Conclusion:

Despite the number of strides taken in the field of topical drug delivery in infectious diseases, it still requires extensive research efforts to have a better perspective of the factors that influence drug permeation along with the mechanism of action with regard to skin penetration and deposition. The final objective of the therapy is to provide a safe and effective therapeutic approach for the management of infectious diseases affecting topical sites leading to enhanced therapeutic efficacy and patient-compliance.
Recent Advances on Prediction of Human Papillomaviruses Risk Types
Authors: Yao Yuhua , Xu Huimin , Li Manzhi , Qi Zhaohui , Liao Bo
Published: January 2019

Background:

Some studies have shown that Human Papillomavirus (HPV) is strongly associated with cervical cancer. As we all know, cervical cancer still remains the fourth most common cancer, affecting women worldwide. Thus, it is both challenging and essential to detect risk types of human papillomaviruses.

Methods:

In order to discriminate whether HPV type is highly risky or not, many epidemiological and experimental methods have been proposed recently. For HPV risk type prediction, there also have been a few computational studies which are all based on Machine Learning (ML) techniques, but adopt different feature extraction methods. Therefore, we conclude and discuss several classical approaches which have got a better result for the risk type prediction of HPV.

Results:

This review summarizes the common methods to detect human papillomavirus. The main methods are sequence- derived features, text-based classification, gap-kernel method, ensemble SVM, Word statistical model, position- specific statistical model and mismatch kernel method (SVM). Among these methods, position-specific statistical model get a relatively high accuracy rate (accuracy=97.18%). Word statistical model is also a novel approach, which extracted the information of HPV from the protein “sequence space” with word statistical model to predict high-risk types of HPVs (accuracy=95.59%). These methods could potentially be used to improve prediction of highrisk types of HPVs.

Conclusion:

From the prediction accuracy, we get that the classification results are more accurate by establishing mathematical models. Thus, adopting mathematical methods to predict risk type of HPV will be the main goal of research in the future.
Advancement of Lipid-Based Nanocarriers and Combination Application with Physical Penetration Technique
Authors: Yang Meng , Gu Yongwei , Tang Xiaomeng , Wang Ting , Liu Jiyong
Published: January 2019

On account of the advantages of transdermal delivery and the application situation of transcutaneous technology in transdermal delivery, the article critically comments on nanosystems as permeation enhancement model. Nanosystems possess great potential for transcutaneous drug delivery. This review focuses on recent advances in lipid-based nanocarriers, including liposome, transfersomes, ethosomes, nanoemulsions, solid lipid nanoparticles, nanostructured lipid carriers and combination application of the lipid-based nanocarriers with microneedle, iontophoresis, electroporation and sonophoresis in the field for the development of the transdermal drug delivery system. We attempted to give an overview of lipid-based nanocarriers with the aim to improve transdermal and dermal drug delivery. A special focus is given to the nanocarrier composition, characteristic and interaction mechanisms through the skin. Recent combination applications of lipid-based nanocarriers with the physical penetration technology demonstrate the superiority of the combined use of nanocarriers and physical methods in drug penetration enhancement compared to their single use. In the future, lipidbased nanocarriers will play a greater role in the field of transdermal and dermal drug delivery.
Antimicrobial Stewardship in the Neonatal Intensive Care Unit: An Update
Authors: Gkentzi Despoina , Dimitriou Gabriel
Published: January 2019

Neonates represent a vulnerable population for infections and neonatal sepsis is a major cause of mortality and morbidity worldwide. Therefore, antimicrobials are the most commonly prescribed drugs in the Neonatal Intensive Care Unit Setting but unfortunately are quite often used inappropriately with various short and long-term effects. The rational use of antimicrobials is of paramount importance in this population and structured antimicrobial stewardship interventions should be in place. These interventions are slightly different from those used in adults and older children due to the particularities of the neonatal medicine. The aim of this review is to provide an update in the field and identify areas for further consideration and future research.
Computational Studies of bis-2-Oxoindoline Succinohydrazides and their In Vitro Cytotoxicity
Authors: Jarapula Ravi , Badavath Vishnu N. , Rekulapally Shriram , Manda Sarangapani
Published: January 2019

Background:

The discovery of clinically relevant EGFR inhibitors for cancer therapy has proven
to be a challenging task. To identify novel and potent EGFR inhibitors, the quantitative structure-activity
relationship (QSAR) and molecular docking approach became a very useful and largely widespread technique
for drug design.

Methods:

We performed the in vitro cytotoxic activity on HEPG-2 cell line and earlier on MCF-7 and A
549 by using MTT assay method. The development of 3D QSAR model of N1,N4-bis(2-oxoindolin-3-
ylidene) succinohydrazides using the stepwise-backward variable methods to generate Multiple Linear Regression
method elucidates the structural properties required for EGFR inhibitory activity and also perform
the Molecular Docking studies on EGFR (PDB ID:1M17). Further, we analysed for Lipinski’s rule of five
to evaluate the drug-likeness and established in silico ADMET properties.

Results:

The resulting cytotoxicity (IC50) values ranged from 9.34 to 100 μM and compared with cisplatin
as a standard. Among the series of compounds, 6j showed good cytotoxic activity on HEPG-2 cell line with
9.34 μM, IC50 value. Most of the evaluated compounds showed good antitumor activity on HEPG-2 than
MCF-7and A549. The developed 3D QSAR Multiple Linear Regression models are statistically significant
with non-cross-validated correlation coefficient r2 = 0.9977, cross-validated correlation coefficient q2 =
0.902 and predicted_r2 = 0.9205. Molecular docking studies on EGFR (PDB ID: 1M17) results, compounds
6d, 6j and 6l showed good dock/PLP scores i.e. -81.28, -73.98 and -75.37, respectively, by interacting with
Leu-694, Val-702 and Gly-772 amino acids via hydrophobic and hydrogen bonds with Asn818 and Met-
769. Further, we analysed drug-likeness and established in silico ADMET properties.

Conclusion:

The results of 3D QSAR studies suggest that the electrostatic and steric descriptors influence
the cytotoxic activity of succinohydrazides. From the molecular docking studies, it is evident that
hydrophobic, hydrogen and Van Der Waal’s interactions determine binding affinities. In addition to this, druglikeness
and ADMET properties were analysed. It is evident that there is a correlation between the QSAR and
docking results. Compound 6j was found to be too lipophilic due to its dihalo substitution on isatin nucleus,
and can act as a lead molecule for further and useful future development of new EGFR Inhibitors.
High-Affinity Detection of Metal-Mediated Nephrotoxicity by Aptamer Nanomaterial Complementation
Authors: Pan Huijuan , Lakshmipriya Thangavel , Gopinath Subash C.B. , Anbu Periasamy
Published: January 2019

:

Nephrotoxicity, a chronic renal disease that results from the accumulation of endogenous
and exogenous toxins in the kidney, disturbs the excretion and detoxification function of the kidney.
Metal-mediated nephrotoxicity is induced by toxic metals/metalloids such as mercury, lead, arsenic,
chromate, uranium, and cadmium. These materials become concentrated in the kidneys and injure the
nephrons. Developing strategies to detect these metal ions will enable the earlier identification of
kidney damage. An aptamer, an artificial antibody generated against a wide range of targets
including metal ions, may be the right tool for the detection of metal ions associated with renal injury.
The use of a detection system consisting of an aptamer and metallic nanoparticles is a potential
way to overcome nephrotoxicity. Here, we discuss the detection of metal-mediated nephrotoxicity
caused by metals/metalloids using the aptamer and nanomaterial-conjugated system.
Anti-Diarrheal Drug Repositioning in Tumour Cell Cytotoxicity
Authors: Elloumi-Mseddi Jihene , Msalbi Dhouha , Fakhfakh Raouia , Aifa Sami
Published: January 2019

Background:

Drug repositioning is becoming an ideal strategy to select new anticancer drugs. In particular, drugs treating the side effects of chemotherapy are the best candidates.

Objective:

In this present work, we undertook the evaluation of anti-tumour activity of two anti-diarrheal drugs (nifuroxazide and rifaximin).

Methods:

Anti-proliferative effect against breast cancer cells (MDA-MB-231, MCF-7 and T47D) was assessed by MTT analysis, the Brdu incorporation, mitochondrial permeability and caspase-3 activity.

Results:

Both the drugs displayed cytotoxic effects on MCF-7, T47D and MDA-MB-231 cells. The lowest IC50 values were obtained on MCF-7 cells after 24, 48 and 72 hours of treatment while T47D and MDA-MB-231 were more resistant. The IC50 values on T47D and MDA-MB-231 cells became significantly low after 72 hours of treatment showing a late cytotoxicity effect especially of nifuroxazide but still less important than that of MCF-7 cells. According to the IC50 values, the non-tumour cell line HEK293 seems to be less sensitive to cytotoxicity especially against rifaximin. Both the drugs have shown an accumulation of rhodamine 123 as a function of the rise of their concentrations while the Brdu incorporation decreased. Despite the absence of a significant difference in the cell cycle between the treated and non-treated MCF-7 cells, the caspase-3 activity increased with the drug concentrations rise suggesting an apoptotic effect.

Conclusion:

Nifuroxazide and rifaximin are used to overcome the diarrheal side effect of anticancer drugs. However, they have shown to be anti-tumour drugs which make them potential dual effective drugs against cancer and the side effects of chemotherapy.