bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancement of Luminous Intensity Emission from Incoherent LED Light Sources within the Detection Angle of 10° Using Metalenses
Authors: Cho Hanlyun , Jeong Heonyeong , Yang Younghwan , Badloe Trevon , Rho Junsuk
Published: January 2022

In this work, we present metalenses (MLs) designed to enhance the luminous intensity of incoherent light-emitting diodes (LEDs) within the detection angles of 0° and 10°. The detection angle of 0° refers to the center of the LED. Because the light emitted from LEDs is incoherent and expressed as a surface light source, they are numerically described as a set of point sources and calculated using incoherent summation. The titanium dioxide (TiO2) and amorphous silicon (a-Si) nanohole meta-atoms are designed; however, the full 2π phase coverage is not reached. Nevertheless, because the phase modulation at the edge of the ML is important, an ML is successfully designed. The typical phase profile of the ML enhances the luminous intensity at the center, and the phase profile is modified to increase the luminous intensity in the target detection angle region. Far field simulations are conducted to calculate the luminous intensity after 25 m of propagation. We demonstrate an enhancement of the luminous intensity at the center by 8551% and 2115% using TiO2 and a-Si MLs, respectively. Meanwhile, the TiO2 and a-Si MLs with the modified phase profiles enhance the luminous intensity within the detection angle of 10° by 263% and 30%, respectively.
Liposomal PHD2 Inhibitors and the Enhanced Efficacy in Stabilizing HIF-1α
Authors: Jian Cheng-Bang , Yu Xu-En , Gao Hua-De , Chen Huai-An , Jheng Ren-Hua , Chen Chong-Yan , Lee Hsien-Ming
Published: January 2022

Prolyl hydroxylase domain-containing protein 2 (PHD2) inhibition, which stabilizes hypoxia-inducible factor (HIF)-1α and thus triggers adaptation responses to hypoxia in cells, has become an important therapeutic target. Despite the proven high potency, small-molecule PHD2 inhibitors such as IOX2 may require a nanoformulation for favorable biodistribution to reduce off-target toxicity. A liposome formulation for improving the pharmacokinetics of an encapsulated drug while allowing a targeted delivery is a viable option. This study aimed to develop an efficient loading method that can encapsulate IOX2 and other PHD2 inhibitors with similar pharmacophore features in nanosized liposomes. Driven by a transmembrane calcium acetate gradient, a nearly 100% remote loading efficiency of IOX2 into liposomes was achieved with an optimized extraliposomal solution. The electron microscopy imaging revealed that IOX2 formed nanoprecipitates inside the liposome’s interior compartments after loading. For drug efficacy, liposomal IOX2 outperformed the free drug in inducing the HIF-1α levels in cell experiments, especially when using a targeting ligand. This method also enabled two clinically used inhibitors—vadadustat and roxadustat—to be loaded into liposomes with a high encapsulation efficiency, indicating its generality to load other heterocyclic glycinamide PHD2 inhibitors. We believe that the liposome formulation of PHD2 inhibitors, particularly in conjunction with active targeting, would have therapeutic potential for treating more specifically localized disease lesions.
Converting non-Mesogenic to Mesogenic Stacking of Amino-s-Triazine-Based Dendrons with p-CN Phenyl Unit by Eliminating Peripheral Dipole
Authors: Lu Yao-Chih , Hsu Yu-Tsz , Yang Tsung-Yen , Liou I-Chun , Wang Sheng-Wei , Huang Po-Chia , Lee Jey-Jau , Lai Long-Li , Hsu Hsiu-Fu
Published: January 2022

Three new amino-s-triazine-based dendrons, 1a, 1b, and 1c, containing an aryl-CN moiety in the dendritic skeleton were prepared in 72–81% yields (1a: R1 = − N(n-C8H17)2, R2 = n-OC8H17, 1b: R1 = R2 = − N(n-C8H17)2, 1c: R1 = − N(n-C8H17)2, R2 = − N(n-C4H9)2). Dendrons 1a with N(n-C8H17)2 and n-OC8H17 peripheral substituents, surprisingly, did not show any mesogenic phase during the thermal process. However, non-mesogenic 1a can be converted to mesogenic 1b or 1c by eliminating the peripheral dipole arising from the alkoxy substituent; dendron 1b only comprising the same N(n-C8H17)2 peripheral groups showed a ~25 °C mesogenic range on heating and ~108 °C mesogenic range on cooling. In contrast, dendron 1c possessing different N(n-CmH2m+1)2 (m = 8 versus m = 4) peripheral units, having similar stacking as 1b, exhibited a columnar phase on thermal treatment, but its mesogenic range (~9 and ~66 °C on heating and cooling, respectively) was much narrower than that of 1b, attributed to 1c’s less flexible alkyl chains in the peripheral part of dendron. Dendron 1a with the alkoxy substituent in the peripheral skeleton, creating additional dipole correspondingly, thus, leads to the dendritic molecules having a non-mesogenic stacking. Without the peripheral dipole for intermolecular side-by-side interaction, dendrons 1b and 1c exhibit a columnar phase on thermal treatment because of the vibration from the peripheral alkyl chain.
Coexistence of Flexo- and Ferro-Electric Effects in an Ordered Assembly of BaTiO3 Nanocubes
Authors: Yasui Kyuichi , Itasaka Hiroki , Mimura Ken-ichi , Kato Kazumi
Published: January 2022

It has been reported that the flexoelectric effect could be dominant in the nanoscale. The discrepancy between theory and experiments on the frequency dependence of the dielectric constant of an ordered assembly of BaTiO3 nanocubes is nearly resolved by assuming the coexistence of flexo- and ferro-electric effects. Although flexoelectric polarizations perpendicular to the applied alternating electric field contribute to the dielectric constant, those parallel to the electric field do not contribute because the magnitude of the flexoelectric polarization does not change due to the mismatch of strain at the interface of the nanocubes. On the other hand, some dielectric response is possible for the ferroelectric component of the polarization parallel to the electric field.
Evaluating the Effectiveness of the Computer-Based Education Platform, Pharmacy5in5, on Pharmacists’ Knowledge of Anticholinergic Toxicity Using a Randomized Controlled Trial
Authors: Hussein Rand , He Zhoushanyue , Bareham Julia , Patel Tejal , Killeen Rosemary , Grindrod Kelly
Published: January 2022

Background: Computer-based education has been widely implemented in healthcare professional development education. However, there has been little examination of the potential for computer-based education to enhance pharmacists’ knowledge. This study aims to assess the effectiveness of computer-based education on improving pharmacists’ knowledge compared to printed education material. Methods: This study was a web-based randomized controlled trial. Participants were randomly allocated to either an intervention group where they had access to the computer-based education module on Pharmacy5in5.ca or to a control group where they had access to printed educational material. Knowledge gain was assessed using a pre- and post-knowledge test. Results: A total of 120 pharmacists were recruited and 101 completed the post-knowledge test (50/60 in the intervention group; 51/60 in the control group). Both groups showed a significant increase in knowledge gain (intervention group: pre-test mean score 19.35 ± 3.56, post-test mean score 22.42 ± 3.812, p value < 0.001; control group pre-test mean score 19.22 ± 3.45, post-test mean score 23.29 ± 3.087, p value < 0.001). However, the difference in knowledge change was not significant between the two groups (22.42 vs. 23.29, p value = 0.333). Conclusions: In this study, a computer-based education module enhanced pharmacists’ knowledge to a similar degree to printed education material. Efforts should be made to provide computer-based education as an option to support pharmacists’ professional development.
Object Coreference in German: The Reflexive sich as a Problem for Derivational Approaches to Binding
Authors: Lee-Schoenfeld Vera , Twiner Nicholas
Published: January 2022

Despite Grewendorf’s well-known German binding data with the double-object verb zeigen ‘show’, where one object reflexively binds the other and which suggests that the direct object (DO) is generated higher than the indirect object (IO), this paper argues for the canonical surface order of IO > DO as base order. We highlight the exceptional status of Grewendorf’s examples, build on scope facts as well as a quantitative acceptability rating study, and exploit the fact that zeigen can also be used as inherently reflexive with idiomatic meaning. Appealing to the base configuration of the pieces of idiomatic expressions and considering different Spell-Out possibilities of coreferential objects in German, we show that the case, number, and gender underspecification of the anaphor sich poses a previously unnoticed problem for derivational approaches to binding.
A Versatile Terahertz Chemical Microscope and Its Application for the Detection of Histamine
Authors: Wang Jin , Sato Kosuke , Yoshida Yuichi , Sakai Kenji , Kiwa Toshihiko
Published: January 2022

Terahertz waves have gained increasingly more attention because of their unique characteristics and great potential in a variety of fields. In this study, we introduced the recent progress of our versatile terahertz chemical microscope (TCM) in the detection of small biomolecules, ions, cancer cells, and antibody–antigen immunoassaying. We highlight the advantages of our TCM for chemical sensing and biosensing, such as label-free, high-sensitivity, rapid response, non-pretreatment, and minute amount sample consumption, compared with conventional methods. Furthermore, we demonstrated its new application in detection of allergic-related histamine at low concentration in buffer solutions.
Impact of Silica Additions on the Phase Composition and Electrical Transport Properties of Ruddlesden-Popper La2NiO4+δ Mixed Conducting Ceramics
Authors: Zakharchuk Kiryl , Bamburov Aleksandr , Naumovich Eugene N. , Vieira Miguel A. , Yaremchenko Aleksey A.
Published: January 2022

The present work explores the possibility of incorporation of silicon into the crystal structure of Ruddlesden-Popper La2NiO4+δ mixed conducting ceramics with the aim to improve the chemical compatibility with lanthanum silicate-based solid electrolytes. Ceramics with the nominal composition La2Ni1−ySiyO4+δ (y = 0, 0.02 and 0.05) were prepared by the glycine nitrate combustion technique and sintered at 1450 °C. While minor changes in the lattice parameters of the tetragonal K2NiF4-type lattice may suggest incorporation of a small fraction of Si into the Ni sublattice, combined XRD and SEM/EDS studies indicate that this fraction is very limited (≪2 at.%, if any). Instead, additions of silica result in segregation of apatite-type La10−xSi6O26+δ and La2O3 secondary phases as confirmed experimentally and supported by the static lattice simulations. Both total electrical conductivity and oxygen-ionic transport in La2NiO4+δ ceramics are suppressed by silica additions. The preferential reactivity of silica with lanthanum oxide opens a possibility to improve the compatibility between lanthanum silicate-based solid electrolytes and La2NiO4+δ-based electrodes by appropriate surface modifications. The promising potential of this approach is supported by preliminary tests of electrodes infiltrated with lanthanum oxide.
Effects of Alkaline-Reduced Water on Gastrointestinal Diseases
Authors: Bajgai Johny , Kim Cheol-Su , Rahman Md. Habibur , Jeong Eun-Sook , Jang Hong-Young , Kim Ka-Eun , Choi JaeHo , Cho Il-Young , Lee Kyu-Jae , Lee Mihyun
Published: January 2022

Living a healthy lifestyle is the most important need in the world today. However, oxidative stress (OS) is caused by several stress-inducing factors such as smoking, alcohol consumption, chronic diseases, and inflammatory responses, oxygen-free radicals are produced in excess and can damage major organs in the body. This phenomenon has been implicated in the pathogenesis of several gastrointestinal (GI) diseases, including gastritis, constipation, and inflammatory bowel diseases, which include Crohn’s disease, ulcerative colitis, functional dyspepsia, acid reflux, diverticular disease, and irritable bowel syndrome. In this review article, we provide a brief overview of the role of OS in the pathogenesis of GI disorders. Additionally, we discuss the therapeutic role of alkaline-reduced water (ARW) on GI diseases and existing studies on ARW related to GI diseases. Furthermore, we believe that findings from this review article will enhance the knowledge of the readers on the role of ARW on OS and inflammation-based GI diseases.
Research on the End-Face Distribution of Rotational Molding Heating Gun Based on Numerical Simulation Method
Authors: Yan Yongchun , Zhang Lixin , Ma Xiao , Wang Huan , Wang Wendong , Zhang Yan
Published: January 2022

The distribution of heating gun ends plays a decisive role in the sidewall properties of finished rotomolded products. To obtain the optimal distribution of the end face of a rotational molding heating gun, the temperature response of the end-face mold under heating gun heating was investigated, and an analysis method based on numerical simulation is proposed. The FDS (fire dynamics simulator) was used to construct a heating model of the heating gun, simulate and obtain a heatmap of the temperature field distribution of a heating gun of Φ30–70 mm, and determine the optimal diameter and heating distance of the heating gun. ANSYS was used to establish the thermal response model of the heat-affected mold, which was combined with the mold structure and thermophysical properties of steel. A temperature field distribution on the inner wall surface of Φ30, Φ50, and Φ70 mm heating guns when heating at each diameter of the end face was obtained and the distribution position of the end face of each diameter heating gun was determined. ANSYS was used to establish the thermal response model of the end-face mold and obtain the temperature field distribution of the inner wall surface of the end-face mold. The size of the heat-affected area of each diameter heating gun was combined, the end-face heating gun distribution was optimized, and the optimal heating gun end-face distribution was obtained. An experimental platform was built, and a validation experiment was set up. Through the analysis and processing of the data of three experiments, the temperature variation curve of each diameter on the inner surface of the end-face mold was obtained. We compare and analyze the simulation and experimental results to determine the feasibility of the FDS + ANSYS method and the correctness and accuracy of the simulation model and the results.
Scheduling by NSGA-II: Review and Bibliometric Analysis
Authors: Rahimi Iman , Gandomi Amir H. , Deb Kalyanmoy , Chen Fang , Nikoo Mohammad Reza
Published: January 2022

NSGA-II is an evolutionary multi-objective optimization algorithm that has been applied to a wide variety of search and optimization problems since its publication in 2000. This study presents a review and bibliometric analysis of numerous NSGA-II adaptations in addressing scheduling problems. This paper is divided into two parts. The first part discusses the main ideas of scheduling and different evolutionary computation methods for scheduling and provides a review of different scheduling problems, such as production and personnel scheduling. Moreover, a brief comparison of different evolutionary multi-objective optimization algorithms is provided, followed by a summary of state-of-the-art works on the application of NSGA-II in scheduling. The next part presents a detailed bibliometric analysis focusing on NSGA-II for scheduling applications obtained from the Scopus and Web of Science (WoS) databases based on keyword and network analyses that were conducted to identify the most interesting subject fields. Additionally, several criteria are recognized which may advise scholars to find key gaps in the field and develop new approaches in future works. The final sections present a summary and aims for future studies, along with conclusions and a discussion.
New Insights from Locally Resolved Hydrodynamics in Stirred Cell Culture Reactors
Authors: Freiberger Fabian , Budde Jens , Ateş Eda , Schlüter Michael , Pörtner Ralf , Möller Johannes
Published: January 2022

The link between hydrodynamics and biological process behavior of antibody-producing mammalian cell cultures is still not fully understood. Common methods to describe dependencies refer mostly to averaged hydrodynamic parameters obtained for individual cultivation systems. In this study, cellular effects and locally resolved hydrodynamics were investigated for impellers with different spatial hydrodynamics. Therefore, the hydrodynamics, mainly flow velocity, shear rate and power input, in a single- and a three-impeller bioreactor setup were analyzed by means of CFD simulations, and cultivation experiments with antibody-producing Chinese hamster ovary (CHO) cells were performed at various agitation rates in both reactor setups. Within the three-impeller bioreactor setup, cells could be cultivated successfully at much higher agitation rates as in the single-impeller bioreactor, probably due to a more uniform flow pattern. It could be shown that this different behavior cannot be linked to parameters commonly used to describe shear effects on cells such as the mean energy dissipation rate or the Kolmogorov length scale, even if this concept is extended by locally resolved hydrodynamic parameters. Alternatively, the hydrodynamic heterogeneity was statistically quantified by means of variance coefficients of the hydrodynamic parameters fluid velocity, shear rate, and energy dissipation rate. The calculated variance coefficients of all hydrodynamic parameters were higher in the setup with three impellers than in the single impeller setup, which might explain the rather stable process behavior in multiple impeller systems due to the reduced hydrodynamic heterogeneity. Such comprehensive insights lead to a deeper understanding of the bioprocess.
An Overview of Molecular Dynamics Simulation for Food Products and Processes
Authors: Smith Andrea , Dong Xin , Raghavan Vijaya
Published: January 2022

Molecular dynamics (MD) simulation is a particularly useful technique in food processing. Normally, food processing techniques can be optimized to favor the creation of higher-quality, safer, more functional, and more nutritionally valuable food products. Modeling food processes through the application of MD simulations, namely, the Groningen Machine for Chemical Simulations (GROMACS) software package, is helpful in achieving a better understanding of the structural changes occurring at the molecular level to the biomolecules present in food products during processing. MD simulations can be applied to define the optimal processing conditions required for a given food product to achieve a desired function or state. This review presents the development history of MD simulations, provides an in-depth explanation of the concept and mechanisms employed through the running of a GROMACS simulation, and outlines certain recent applications of GROMACS MD simulations in the food industry for the modeling of proteins in food products, including peanuts, hazelnuts, cow’s milk, soybeans, egg whites, PSE chicken breast, and kiwifruit.
Fault Detection Method Based on Global-Local Marginal Discriminant Preserving Projection for Chemical Process
Authors: Li Yang , Ma Fangyuan , Ji Cheng , Wang Jingde , Sun Wei
Published: January 2022

Feature extraction plays a key role in fault detection methods. Most existing methods focus on comprehensive and accurate feature extraction of normal operation data to achieve better detection performance. However, discriminative features based on historical fault data are usually ignored. Aiming at this point, a global-local marginal discriminant preserving projection (GLMDPP) method is proposed for feature extraction. Considering its comprehensive consideration of global and local features, global-local preserving projection (GLPP) is used to extract the inherent feature of the data. Then, multiple marginal fisher analysis (MMFA) is introduced to extract the discriminative feature, which can better separate normal data from fault data. On the basis of fisher framework, GLPP and MMFA are integrated to extract inherent and discriminative features of the data simultaneously. Furthermore, fault detection methods based on GLMDPP are constructed and applied to the Tennessee Eastman (TE) process. Compared with the PCA and GLPP method, the effectiveness of the proposed method in fault detection is validated with the result of TE process.
Response Surface Optimization for Antioxidant Extraction and Attributes Liking from Roasted Rice Germ Flavored Herbal Tea
Authors: Rittisak Sriwiang , Charoen Ratchanee , Choosuk Natthaya , Savedboworn Wanticha , Riansa-ngawong Wiboon
Published: January 2022

The optimal process conditions when examining the antioxidant potential, total polyphenol content, and attribute liking in roasted rice germ flavored herbal tea were investigated using response surface methodology (RSM). The influence upon the extraction process of time and temperature was assessed using a full factorial design on three levels with two variables (32), involving five central point replicates. Extraction temperature (70 °C, 80 °C, and 90 °C) and extraction time (3 min, 4.5 min, and 6 min) served as independent variables, while the dependent variables were allocated to the regression equation to determine antioxidant activity (R2 = 0.941) along with total polyphenol content (R2 = 0.849), flavor liking score (R2 = 0.758), and overall liking score (R2 = 0.816). Following experimentation, it was determined that the optimal time and temperature conditions to maximize total polyphenol content, antioxidant activity, flavor, and overall liking score were in a range of 86 °C to 90 °C for 3.4 min to 5.9 min. When these conditions were imposed, the antioxidant potential, total polyphenol content, flavor, and overall liking score were >70% for DPPH scavenging activity, >75 mgGAE/g, >6.7 (like moderately), and >6.5 (like moderately), respectively.
Comparison of Different Label-Free Techniques for the Semi-Absolute Quantification of Protein Abundance
Authors: Millán-Oropeza Aarón , Blein-Nicolas Mélisande , Monnet Véronique , Zivy Michel , Henry Céline
Published: January 2022

In proteomics, it is essential to quantify proteins in absolute terms if we wish to compare results among studies and integrate high-throughput biological data into genome-scale metabolic models. While labeling target peptides with stable isotopes allow protein abundance to be accurately quantified, the utility of this technique is constrained by the low number of quantifiable proteins that it yields. Recently, label-free shotgun proteomics has become the “gold standard” for carrying out global assessments of biological samples containing thousands of proteins. However, this tool must be further improved if we wish to accurately quantify absolute levels of proteins. Here, we used different label-free quantification techniques to estimate absolute protein abundance in the model yeast Saccharomyces cerevisiae. More specifically, we evaluated the performance of seven different quantification methods, based either on spectral counting (SC) or extracted-ion chromatogram (XIC), which were applied to samples from five different proteome backgrounds. We also compared the accuracy and reproducibility of two strategies for transforming relative abundance into absolute abundance: a UPS2-based strategy and the total protein approach (TPA). This study mentions technical challenges related to UPS2 use and proposes ways of addressing them, including utilizing a smaller, more highly optimized amount of UPS2. Overall, three SC-based methods (PAI, SAF, and NSAF) yielded the best results because they struck a good balance between experimental performance and protein quantification.
“It’s Your Breath in Our Lungs”: Sean Feucht’s Praise and Worship Music Protests and the Theological Problem of Pandemic Response in the U.S.
Authors: Perez Adam A.
Published: January 2022

In response to U.S. government restrictions imposed as part of a nationwide response to the COVID-19 pandemic, charismatic worship leader Sean Feucht began a series of worship concerts. Feucht positioned these protests as expressions of Christian religious freedom in opposition to mandated church closings and a perceived double-standard regarding the large gatherings of protesters over police violence against Black and Brown persons. Government restrictions challenged the sine qua non liturgical act of encounter with God for evangelicals, Pentecostals, and Charismatics: congregational singing in Praise and Worship. However, as Feucht’s itinerant worship concerts traversed urban spaces across the U.S. to protest these restrictions, the events gained a double valence. Feucht and event attendees sought to channel God’s power through musical worship to overturn government mandates and, along the way, they invoked longstanding social and racial prejudices toward urban spaces. In this essay, I argue that Feucht’s events reveal complex theological motivations that weave together liturgical-theological, social, and political concerns. Deciphering this complex tapestry requires a review of both the history of evangelical engagement with urban spaces and the theological history of Praise and Worship. Together, these two sets of historical resources generate a useful frame for considering how Feucht, as a charismatic musical worship leader, attempts to wield spiritual power through musical praise to change political situations and the social conditions.
Parents’ Expectations about Educational Institutions during the Pandemic: Results of Nationwide Questionnaire Research in Poland
Authors: Szczudlińska-Kanoś Agnieszka , Marzec Małgorzata , Freund Bożena
Published: January 2022

(1) Background: The coronavirus pandemic has highlighted the problem of combining work and private life. The pandemic conditions have turned out to be particularly difficult for parents who, due to changes in the organization of the education system, have been forced to reconcile their professional duties with the raising of childcare. Thanks to the recommendations for cooperation between schools and parents proposed in this study, it will be possible to reduce the risk and uncertainty of achieving common goals of the education system. (2) Methods: In the preparation of nationwide research, a questionnaire was provided to a sample of 10,331 respondents, including 7800 professional parents, in a trial form before a transition to the study of children. (3) Results: The analysis of the data showed that educational institutions should shape their activities based on cooperation with the family environment of children. (4) Conclusions: Educational institutions can help working parents in times of increased uncertainty. Parents reported that in caring for children, it would be helpful to operate educational institutions in stationary mode. Moreover, they expect increases in extracurricular and extra-curricular activities.
Towards Sustainable Retirement Planning of Wageworkers in Thailand: A Qualitative Approach in Behavioral Segmentation and Financial Pain Point Identification
Authors: Ketkaew Chavis , Van Wouwe Martine , Jorissen Ann , Cassimon Danny , Vichitthamaros Preecha , Wongsaichia Sasichakorn
Published: January 2022

Thailand recently reached “aged” society status, signifying that over twenty percent of the population is over sixty. Considering that Thailand has a low literacy rate, a fractured pension system, and no regulations that could provide sufficient income to cover basic needs after retirement, there will be economic repercussions if the situation is not handled soon. The government and financial institutions have been encouraging Thai citizens to prepare retirement plans but lack understanding of the root causes of being unprepared for retirement. The objectives of this qualitative research were to explore the behavior, knowledge, and preparedness towards retirement in governmental and private wageworkers. Moreover, the study aims to identify the pain points of being unprepared for retirement and deliver the optimal solutions and sustainable retirement plans suitable for each segment. This article employed a sample of 46 wageworkers in Khon Kaen, Thailand with ages ranging from 20 to 59 years old. Qualitative semi-structured in-depth interviews and qualitative content analysis were conducted with the respondents asking about their income, expenses, pains, and problems towards saving for retirement, their desired outcome after they retire, and how they would achieve it. The framework used for the in-depth qualitative interview was by utilizing the customer, problem, and solution zoom tool. The research contributions were to facilitate Thai citizens being ready for retirement stages and overcome post-retirement risks sustainably. The results revealed that the sample could be divided into four segments by their characteristics. Two low-income segments share the same traits and behaviors that can prove that financial literacy plays an essential role in retirement readiness. Lower-income wage workers do not have their money put in place to prepare for retirement. Additionally, this article discussed the study’s implications for wageworkers, employers, and the Thai government. This article recommended that Thai citizens should accumulate wealth in various ways, including investment in financial assets and earning additional income from a second job. Employers should provide suitable retirement contribution schemes. The government should launch a policy enabling above-60-year-old seniors to continue working.
A Comparative Study of Post-Quantum Cryptosystems for Internet-of-Things Applications
Authors: Septien-Hernandez Jose-Antonio , Arellano-Vazquez Magali , Contreras-Cruz Marco Antonio , Ramirez-Paredes Juan-Pablo
Published: January 2022

The existence of quantum computers and Shor’s algorithm poses an imminent threat to classical public-key cryptosystems. These cryptosystems are currently used for the exchange of keys between servers and clients over the Internet. The Internet of Things (IoT) is the next step in the evolution of the Internet, and it involves the connection of millions of low-powered and resource-constrained devices to the network. Because quantum computers are becoming more capable, the creation of a new cryptographic standard that cannot be compromised by them is indispensable. There are several current proposals of quantum-resistant or post-quantum algorithms that are being considered for future standards. Given that the IoT is increasing in popularity, and given its resource-constrained nature, it is worth adapting those new standards to IoT devices. In this work, we study some post-quantum cryptosystems that could be suitable for IoT devices, adapting them to work with current cryptography and communication software, and conduct a performance measurement on them, obtaining guidelines for selecting the best for different applications in resource-constrained hardware. Our results show that many of these algorithms can be efficiently executed in current IoT hardware, providing adequate protection from the attacks that quantum computers will eventually be capable of.
Characterization of Cardiopulmonary Interactions and Exploring Their Prognostic Value in Acute Bronchiolitis: A Prospective Cardiopulmonary Ultrasound Study
Authors: Rodriguez-Gonzalez Moises , Rodriguez-Campoy Patricia , Estalella-Mendoza Ana , Castellano-Martinez Ana , Flores-Gonzalez Jose Carlos
Published: January 2022

We aimed to delineate cardiopulmonary interactions in acute bronchiolitis and to evaluate the capacity of a combined cardiopulmonary ultrasonography to predict the need for respiratory support. This was a prospective observational single-center study that includes infants <12 month of age admitted to a hospital due to acute bronchiolitis. All the included patients underwent clinical, laboratory and cardiopulmonary ultrasonographic evaluation at the same time point within 24 h of hospital admission. The existence of significant correlation between cardiac and respiratory parameters was the primary outcome. The association of different cardiopulmonary variables with the need of respiratory support higher than O2, the length of stay hospitalization, the PICU stay and the duration of respiratory support were a secondary outcome. We enrolled 112 infants (median age 1 (0.5–3) months; 62% males) hospitalized with acute bronchiolitis. Increased values of the pulmonary variables (BROSJOD score, pCO2 and LUS) showed moderate correlations with NT-proBNP and all echocardiographic parameters indicative of pulmonary hypertension and myocardial dysfunction (Tei index). Up to 36 (32%) infants required respiratory support during the hospitalization. This group presented with higher lung ultrasound score (p < 0.001) and increased values of NT-proBNP (p < 0.001), the Tei index (p < 0.001) and pulmonary artery pressures (p < 0.001). All the analyzed respiratory and cardiac variables showed moderate-to-strong correlations with the LOS of hospitalization and the time of respiratory support. Lung ultrasound and echocardiography showed a moderate-to-strong predictive accuracy for the need of respiratory support in the ROC analysis, with the AUC varying from 0.74 to 0.87. Those cases of bronchiolitis with a worse pulmonary status presented with a more impaired cardiac status. Cardiopulmonary ultrasonography could be a useful tool to easily identify high-risk populations for complicated acute bronchiolitis hospitalization.
Critical Assessment of Clean-Up Techniques Employed in Simultaneous Analysis of Persistent Organic Pollutants and Polycyclic Aromatic Hydrocarbons in Fatty Samples
Authors: Drábová Lucie , Dvořáková Darina , Urbancová Kateřina , Gramblička Tomáš , Hajšlová Jana , Pulkrabová Jana
Published: January 2022

Interference of residual lipids is a very common problem in ultratrace analysis of contaminants in fatty matrices. Therefore, quick and effective clean-up techniques applicable to multiple groups of analytes are much needed. Cartridge and dispersive solid-phase extraction (SPE and dSPE) are often used for this purpose. In this context, we evaluated the lipid clean-up efficiency and performance of four commonly used sorbents—silica, C18, Z-Sep, and EMR-lipid—for the determination of organic pollutants in fatty fish samples (10%) extracted using ethyl acetate or the QuEChERS method. Namely, 17 polychlorinated biphenyls (PCBs), 22 organochlorine pesticides (OCPs), 13 brominated flame retardants (BFRs), 19 per- and polyfluoroalkyl substances (PFAS), and 16 polycyclic aromatic hydrocarbons (PAHs) were determined in this study. The clean-up efficiency was evaluated by direct analysis in real time coupled with time-of-flight mass spectrometry (DART-HRMS). The triacylglycerols (TAGs) content in the purified extracts were significantly reduced. The EMR-lipid sorbent was the most efficient of the dSPE sorbents used for the determination of POPs and PAHs in this study. The recoveries of the POPs and PAHs obtained by the validated QuEChERS method followed by the dSPE EMR-lipid sorbent ranged between 59 and 120%, with repeatabilities ranging between 2 and 23% and LOQs ranging between 0.02 and 1.50 µg·kg−1.
Prenatal PM2.5 Exposure in Relation to Maternal and Newborn Telomere Length at Delivery
Authors: Durham Teresa , Guo Jia , Cowell Whitney , Riley Kylie W. , Wang Shuang , Tang Deliang , Perera Frederica , Herbstman Julie B.
Published: January 2022

Particulate matter with an aerodynamic diameter of 2.5 μm or less (PM2.5) is a ubiquitous air pollutant that is increasingly threatening the health of adults and children worldwide. One health impact of elevated PM2.5 exposure is alterations in telomere length (TL)—protective caps on chromosome ends that shorten with each cell division. Few analyses involve prenatal PM2.5 exposure, and paired maternal and cord TL measurements. Here, we analyzed the association between average and trimester-specific prenatal PM2.5 exposure, and maternal and newborn relative leukocyte TL measured at birth among 193 mothers and their newborns enrolled in a New-York-City-based birth cohort. Results indicated an overall negative relationship between prenatal PM2.5 and maternal TL at delivery, with a significant association observed in the second trimester (β = −0.039, 95% CI: −0.074, −0.003). PM2.5 exposure in trimester two was also inversely related to cord TL; however, this result did not reach statistical significance (β = −0.037, 95% CI: −0.114, 0.039), and no clear pattern emerged between PM2.5 and cord TL across the different exposure periods. Our analysis contributes to a limited body of research on ambient air pollution and human telomeres, and emphasizes the need for continued investigation into how PM2.5 exposure during pregnancy influences maternal and newborn health.
Effects of Soil Quality on the Microbial Community Structure of Poorly Evolved Mediterranean Soils
Authors: Camacho Antonio , Mora César , Picazo Antonio , Rochera Carlos , Camacho-Santamans Alba , Morant Daniel , Roca-Pérez Luis , Ramos-Miras José Joaquín , Rodríguez-Martín José A. , Boluda Rafael
Published: January 2022

Physical and chemical alterations may affect the microbiota of soils as much as the specific presence of toxic pollutants. The relationship between the microbial diversity patterns and the soil quality in a Mediterranean context is studied here to test the hypothesis that soil microbiota is strongly affected by the level of anthropogenic soil alteration. Our aim has been to determine the potential effect of organic matter loss and associated changes in soil microbiota of poorly evolved Mediterranean soils (Leptosols and Regosols) suffering anthropogenic stress (i.e., cropping and deforestation). The studied soils correspond to nine different sites which differed in some features, such as the parent material, vegetation cover, or soil use and types. A methodological approach has been used that combines the classical physical and chemical study of soils with molecular characterization of the microbial assemblages using specific primers for Bacteria, Archaea and ectomycorrhizal Fungi. In agreement with previous studies within the region, physical, chemical and biological characteristics of soils varied notably depending on these factors. Microbial biomass, soil organic matter, and moisture, decreased in soils as deforestation increased, even in those partially degraded to substitution shrubland. Major differences were observed in the microbial community structure between the mollic and rendzic Leptosols found in forest soils, and the skeletic and dolomitic Leptosols in substitute shrublands, as well as with the skeletic and dolomitic Leptosols and calcaric Regosols in dry croplands. Forest soils displayed a higher microbial richness (OTU’s number) and biomass, as well as more stable and connected ecological networks. Here, we point out how human activities such as agriculture and other effects of deforestation led to changes in soil properties, thus affecting its quality driving changes in their microbial diversity and biomass patterns. Our findings demonstrate the potential risk that the replacement of forest areas may have in the conservation of the soil’s microbiota pool, both active and passive, which are basic for the maintenance of biogeochemical processes.
Spatial–Temporal Variations, Ecological Risk Assessment, and Source Identification of Heavy Metals in the Sediments of a Shallow Eutrophic Lake, China
Authors: Su Xiaomei , Ling Hong , Wu Dan , Xue Qingju , Xie Liqiang
Published: January 2022

The contamination of heavy metals (Pb, Cr, Hg, Cd, Ni, Cu, Zn, As, and Sb) in the sediments were investigated in Lake Yangcheng, a eutrophic lake in China. Results showed that the average concentrations of each metal in the surface sediments generally exceeded their corresponding background values. Higher values were observed in deeper zones, supporting the retention and accumulation of heavy metals in the core sediments. The spatial distributions of metal averages, pollution load index (PLI), and combined ecological risk index (RI) revealed that ecological risks were highest in the west lake, followed by middle lake, and were lowest in the east section. For the temporal variations of metal contents, the highest concentration was usually observed in the winter. However, the seasonal dynamics of Hg showed a different pattern with higher values in the autumn and lower values in the winter. According to contamination factor (CF), the Hg and Sb contaminations were considerable, while the other metals were moderate contamination. In terms of geoaccumulation index (Igeo) values, sediments were moderately–heavily polluted by Sb and moderately polluted by Hg, Cd, and Ni. Meanwhile, Hg exhibited a considerable health risk, while Cd and Sb were moderate risks, based on single ecological risk index (Er) values. Significant positive correlations among heavy metals and principal component analysis (PCA) indicated that anthropogenic activities were major sources. The source of Sb might be different from other metals, with industrial discharge as the main loading. This study highlighted the urgency of taking measures to prevent Hg, Sb, and Cd pollutions in Lake Yangcheng, especially the west region of this lake.
Accumulation, Depuration, and Biological Effects of Polystyrene Microplastic Spheres and Adsorbed Cadmium and Benzo(a)pyrene on the Mussel Mytilus galloprovincialis
Authors: von Hellfeld Rebecca , Zarzuelo María , Zaldibar Beñat , Cajaraville Miren P. , Orbea Amaia
Published: January 2022

Filter feeders are target species for microplastic (MP) pollution, as particles can accumulate in the digestive system, disturbing feeding processes and becoming internalized in tissues. MPs may also carry pathogens or pollutants present in the environment. This work assessed the influence of polystyrene (PS) MP size and concentration on accumulation and depuration time and the role of MPs as vectors for metallic (Cd) and organic (benzo(a)pyrene, BaP) pollutants. One-day exposure to pristine MPs induced a concentration-dependent accumulation in the digestive gland (in the stomach and duct lumen), and after 3-day depuration, 45 µm MPs appeared between gill filaments, while 4.5 µm MPs also occurred within gill filaments. After 3-day exposure to contaminated 4.5 µm MPs, mussels showed increased BaP levels whilst Cd accumulation did not occur. Here, PS showed higher affinity to BaP than to Cd. Three-day exposure to pristine or contaminated MPs did not provoke significant alterations in antioxidant and peroxisomal enzyme activities in the gills and digestive gland nor in lysosomal membrane stability. Exposure to dissolved contaminants and to MP-BaP caused histological alterations in the digestive gland. In conclusion, these short-term studies suggest that MPs are ingested and internalized in a size-dependent manner and act as carriers of the persistent organic pollutant BaP.
Determination of Parabens, Bisphenol A and Its Analogs, Triclosan, and Benzophenone-3 Levels in Human Urine by Isotope-Dilution-UPLC-MS/MS Method Followed by Supported Liquid Extraction
Authors: Chen Hsin-Chang , Chang Jung-Wei , Sun Yi-Chen , Chang Wan-Ting , Huang Po-Chin
Published: January 2022

The development of a rapid analytical approach for determining levels of antibacterial agents, plasticizers, and ultraviolet filters in biosamples is crucial for individual exposure assessment. We developed an analytical method to determine the levels of four parabens—bisphenols A (BPA) and its analogs, triclosan (TCS), triclocarban, and benzophenone-3 (BP-3)—in human urine. We further measured the levels of these chemicals in children and adolescents. We used a supported liquid extraction (SLE) technique coupled with an isotope-dilution ultraperformance liquid chromatography-tandem mass spectrometry (ID-UPLC-MS/MS) method to assess the detection performance for these chemicals. Forty-one urine samples from 13 children and 28 adolescents were assessed to demonstrate the capability and feasibility of our method. An acceptable recovery (75.6–102.4%) and matrix effect (precision < 14.2%) in the three-level spiked artificial urine samples were achieved, and good performance of the validated ID-UPLC-MS/MS method regarding linearity, limits of detection, and quantitation was achieved. The within-run and between-run accuracy and precision also demonstrated the sensitivity and stability of this analytical method, applied after SLE. We concluded that the ID-UPLC-MS/MS method with SLE pretreatment is a valuable analytical method for the investigation of urinary antibacterial agents, plasticizers, and ultraviolet filters in humans, useful for human biomonitoring.
The Carcinogenic Properties of Overlooked yet Prevalent Polycyclic Aromatic Hydrocarbons in Human Lung Epithelial Cells
Authors: Bauer Alison , Siegrist Katelyn , Wolff Melanie , Nield Lindsey , Brüning Thomas , Upham Brad , Käfferlein Heiko , Plöttner Sabine
Published: January 2022

The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic hydrocarbons (PAHs) are components of both indoor (e.g., tobacco smoke and cookstoves) and outdoor (e.g., wildfires and industrial and vehicle emissions) air pollution, thus a human health concern. However, few studies have evaluated the adverse effects of low molecular weight (LMW) PAHs, the most abundant PAHs in the environment. We hypothesized that LMW PAHs combined with the carcinogenic PAH benzo[a]pyrene (B[a]P) act as co-carcinogens in human lung epithelial cell lines (BEAS-2B and A549). Therefore, in this paper, we evaluate several endpoints, such as micronuclei, gap junctional intercellular communication (GJIC) activity, cell cycle analysis, anti-BPDE-DNA adduct formation, and cytotoxicity after mixed exposures of LMW PAHs with B[a]P. The individual PAH doses used for each endpoint did not elicit cytotoxicity nor cell death and were relevant to human exposures. The addition of a binary mixture of LMW PAHs (fluoranthene and 1-methylanthracene) to B[a]P treated cells resulted in significant increases in micronuclei formation, dysregulation of GJIC, and changes in cell cycle as compared to cells treated with either B[a]P or the binary mixture alone. In addition, anti-BPDE-DNA adducts were significantly increased in human lung cells treated with B[a]P combined with the binary mixture of LMW PAHs as compared to cells treated with B[a]P alone, further supporting the increased co-carcinogenic potential by LMW PAHs. Collectively, these novel studies using LMW PAHs provide evidence of adverse pulmonary effects that should warrant further investigation.
Single-Particle and Collective Structures in Neutron-Rich Sr Isotopes
Authors: Sieja Kamila
Published: January 2022

Neutron-rich Sr nuclei around N=60 exhibit a sudden shape transition from a spherical ground state to strongly prolate-deformed. Recently, much new insight into the structure of Sr isotopes in this region has been gained through experimental studies of the excited levels, transition strengths, and spectroscopic factors. In this work, a “classic” shell model description of strontium isotopes from N=50 to N=58 is provided, using a natural valence space outside the 78Ni core. Both even–even and even–odd isotopes are addressed. In particular, spectroscopic factors are computed to shed more light on the structure of low-energy excitations and their evolution along the Sr chain. The origin of deformation at N=60 is mentioned in the context of the present and previous shell model and Monte Carlo shell model calculations.