bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Response to [177Lu]Lu-PSMA Therapy in mCRPC Using Machine Learning
Authors: Gong Kaiyuan , Magnier Baptiste , L’hostis Salomé , Borrely Fanny , Le Bon Sébastien , Houede Nadine , Mamou Adel , Maimoun Laurent , Kotzki Pierre Olivier , Boudousq Vincent
Published: October 2024

Background/Objectives: Radioligandtherapy (RLT) with [177Lu]Lu-PSMA has been newly introduced as a routine treatment for metastatic castration-resistant prostate cancer (mCRPC). However, not all patients can tolerate the entire therapeutic sequence, and in some cases, the treatment may prove ineffective. In real-world conditions, the aim is to distinguish between patients who fully benefit from treatment (those who respond effectively and tolerate the entire therapeutic sequence) and those who do not respond or cannot tolerate the entire sequence. This study explores predictive factors to distinguish between fully beneficial RLT treatment patients (FBTP) and not fully beneficial RLT treatment patients (NFBTP). The objective was to enhance the understanding of predictive factors influencing RLT effectiveness and to highlight the significance of machine learning in optimizing patient selection for treatment planning. Methods: Data from 25 mCRPC patients, categorized as FBTP (11) or NFBTP (14) to RLT, were analyzed. The dataset included clinical, imaging, and biological parameters. Data analysis techniques, including exploratory data analysis and feature engineering, were used to develop machine learning models for predicting patient outcomes. Results: Imaging data analysis revealed statistically significant differences in the renal uptake intensity of Choline between the two groups. A discordance of FDG+ and PSMA− was identified as a potential indicator of NFBTP. The integration of biological data enhanced the model’s predictive capability, achieving an accuracy of 0.92, a sensitivity of 0.96, and a precision of 0.96. Adding blood parameters like neutrophils, leukocytes, and alkaline phosphatase greatly increased prediction accuracy. Conclusions: This study emphasizes the significance of an integrated approach that merges imaging and biological data, thereby augmenting the predictive accuracy of patient outcomes in RLT with [177Lu]Lu-PSMA. In particular, including Choline PET among the imaging parameters provides unique insights into the predictive factors affecting RLT efficacy. This approach not only deepens the understanding of predictive factors but also underscores the utility of machine learning in refining the patient selection process for optimized treatment planning.
Extracting Meso- and Microscale Patterns of Urban Morphology Evolution: Evidence from Binhai New Area of Tianjin, China
Authors: Huang Xiaojin , Cheng Ran , Wu Jun , Yang Wenjian , Zhang Longhao , Li Pengbo , Zhu Wenzhe
Published: October 2024

Understanding and recognizing urban morphology evolution is a crucial issue in urban planning, with extensive research dedicated to detecting the extent of urban expansion. However, as urban development patterns shift from incremental expansion to stock optimization, related studies on meso- and microscale urban morphology evolution face limitations such as insufficient spatiotemporal data granularity, poor generalizability, and inability to extract internal evolution patterns. This study employs deep learning and meso-/microscopic urban form indicators to develop a generic framework for extracting and describing the evolution of meso-/microscale urban morphology. The framework includes three steps: constructing specific urban morphology datasets, semantic segmentation to extract urban form, and mapping urban form evolution using the Tile-based Urban Change (TUC) classification system. We applied this framework to conduct a combined quantitative and qualitative analysis of the internal urban morphology evolution of Binhai New Area from 2009 to 2022, with detailed visualizations of morphology evolution at each time point. The study identified that different locations in the area exhibited seven distinct evolution patterns: edge areal expansion, preservation of developmental potential, industrial land development pattern, rapid comprehensive demolition and construction pattern, linear development pattern, mixed evolution, and stable evolution. The results indicate that in the stock development phase, high-density urban areas exhibit multidimensional development characteristics by region, period, and function. Our work demonstrates the potential of using deep learning and grid classification indicators to study meso-/microscale urban morphology evolution, providing a scalable, cost-effective, quantitative, and portable approach for historical urban morphology understanding.
Synthesis of Methyl 2-((4R)-3-Acryloyl-4-phenyloxazolidin-2-yl)acetates
Authors: Pilotzi Xahuentitla Hugo , Ortega Montes Jesús Guadalupe , Gnecco Medina Dino Hernán , Terán Vázquez Joel Luis , Hernández Núñez Emanuel , Orea Flores Maria Laura
Published: October 2024

The chiral oxazolidine moiety is an important core in asymmetric synthesis due to its ability to participate in various stereoselective chemical reactions and because it forms part of more complex and important active compounds. Therefore, in this letter we report a convenient diastereoselective and practical strategy for the synthesis of chiral methyl 2-((4R)-3-acryloyl-4-phenyloxazolidin-2-yl)acetates, starting from (R)-(–)-2-phenylglycinol and methyl propiolate, which were obtained via two simple chemical and stereoselective reactions.
High-Temperature Deformation Behaviour of UNS S32750 Super Duplex Stainless Steel (SDSS) Alloy
Authors: Cojocaru Vasile Dănuț , Șerban Nicolae , Cojocaru Elisabeta Mirela , Zărnescu-Ivan Nicoleta
Published: October 2024

In this study, the high-temperature deformation behaviour of the UNS S32750 Super Duplex Stainless Steel (SDSS) alloy was investigated by means of deformability and microstructure evolution in the (1050–1200) °C temperature (T) range. The deformability of the UNS S32750 SDSS alloy was investigated by the up-setting method using a gravity-drop hammer, with the following deformation energy/impact energy (E∗): 545.2 J, 1021.5 J, 1480.6 J, and 1905.3 J. Data referring to deformation resistance (σc′) and mechanical work (A∗) as a function of deformation temperature (T) and deformation energy/impact energy (E∗) were obtained and analysed. It was shown that increasing the deformation temperature leads to an increase in the obtained deformation degree (degree of reduction in height). By analysing the rate of increase in the deformation degree as a function of the applied impact energy, it was shown that the rate of increase in the deformation degree rises with the increase in the applied impact energy. Also, it was observed that the evolution of the deformation resistance (σc′) as a function of temperature (T) shows a decreasing tendency while increasing the deformation temperature for all impact energies and that the evolution of the mechanical work (A∗) as a function of temperature (T) shows a decreasing tendency while increasing the deformation temperature for all impact energies. The microstructure evolution of the UNS S32750 SDSS alloy was investigated by X-ray diffraction (XRD) and Scanning Electron Microscopy-Electron Backscatter Diffraction (SEM-EBSD) techniques. It was observed that, in all cases, the microstructure shows intensely deformed grains, strongly elongated in the rolling direction in both ferrite (δ) and austenite (γ) intensely deformed grains. The intensity of grain deformation is increasing with the increase in the applied deformation degree. Also, it was observed that increasing the deformation temperature leads to a strong increase in the weight fraction of the dynamically recrystallised (DRX) ferrite (δ) grains.
Study on the Properties of All-Solid Waste Fluidized Filling Materials Applied to Mine Void Area Filling Engineering
Authors: Lu Yuting , Yang Junjie , Wu Yalei , Lu Ruifan , Li Yunhong , Zhang Lixiang , Guo Jiangtao
Published: October 2024

The extraction of mining resources, as well as processing processes such as ore beneficiation and smelting, generate large amounts of tailings that are difficult to directly utilize. Meanwhile, substantial filling materials are required for the voids formed after mining operations, and the environmental issues and safety hazards brought on by massive solid waste disposal cannot be ignored. By utilizing solid waste with alkaline and pozzolanic activity as the binder component and gold tailings as filler aggregate to prepare filler material to fill up the void areas, the purpose of waste treatment can be achieved. In this study, salt sludge, steel slag, ground granulated blast furnace slag, and gold tailings were used to prepare all-solid waste fluidized filling material for filling mine void areas, which not only solves the engineering safety problem of easy collapse of the mine airspace in the mining process but also ensures a backfill effect with high strength, which continuously guarantees the uninterrupted progress of the mining project. At the same time, the preparation of fluidized materials can consume a large amount of tailings and other solid waste, solving the problem of their stockpiling. The components of the solid wastes used are all general industrial solid wastes, so the preparation of the fluidized materials will not have an impact on the surrounding environment. The effects of binder ratios on the workability of the filling materials were investigated by means of the slump and slump flow tests. Combined with the unconfined compressive strength test, the change in backfill material strength with curing age and the water–binder ratio was studied. The experimental results showed that the slump and slump flow value of the filling material were positively correlated with the water–binder ratio. The water–binder ratio range satisfying a slump value of 180~260 mm and a slump flow value not less than 400 mm was 0.95~1.106. However, the strength decreased with the increase in the water–binder ratio, conforming to a hyperbolic relationship. The all-solid waste fluidized filling material had strengths not less than 0.22, 1.09, and 1.95 MPa at 3, 7, and 28 d, respectively, meeting the workability requirements. Finally, a method for determining the optimal range of water–binder ratio considering both workability performance and strength is proposed based on the relationship between slump value, slump flow value, unconfined compressive strength, and the water–binder ratio.
Effects of Pressure, Surfactant Concentration, and Heat Flux on Pool Boiling Using Expanding Microchanneled Surface for Two-Phase Immersion Cooling
Authors: Hu Yifei , Fu Dengwei , Dang Chaobin , Hong Sihui
Published: October 2024

Deionized water is replacing fluorinated liquids as the preferred choice for two-phase immersion cooling in data centers. Yet, insufficient bubble removal capability at low saturated pressure is a key challenge hindering the widespread application. To solve this issue, this study employs non-ionic surfactant (Tween 20) and asymmetric structures (expanding microchannel) to enhance the boiling performances of deionized water under sub-atmospheric pressure. The research examines the effects of pressure (8.8~38.5 kPa), surfactant concentration (0.1~0.5 mL/L), and heat flux density (10~180 W/cm2) on the boiling heat transfer characteristics and analyzes the mechanism of unusual temperature oscillations induced by surfactants. It was found that the trade-off between the sub-atmospheric pressure, surface tension coefficient, and reduced static contact angle results in pronounced intermittent boiling on the heated surface. Even with the addition of surfactants, the improvement in heat transfer requires demanding conditions. Boiling enhancement throughout all heat flux conditions was achieved when the surfactant concentration was higher than 0.2 mL/L for the expanding microchanneled surface. The heat transfer coefficient reached 6.89 W·cm−2·K−1 under 8.8 kPa, which was 45% higher than without the surfactant. Under the same heat flux and sub-atmospheric pressure, as the concentration increased from 0.1 to 0.5 mL/L, the amplitudes of temperature fluctuation of the plane surface and expanding microchanneled surface decreased from 10 K to 2 K and 18 K to 1 K, respectively. The onset of nucleate boiling and wall superheat of the expanding microchanneled surface gradually decreased with the increase in surfactant concentration, where the onset of nucleate boiling decreased by 10.54 K. When the heat flux is 160 W/cm2, the wall superheat is reduced by 12.8 K.
Elaboration and Characterization of Electrodes from Robinia pseudoacacia and Azadirachta indica Charcoal Powder with Coconut Bio-Pitch as a Binder
Authors: Zingbe Epiphane , Kongnine Damgou Mani , Agbomahena Bienvenu M. , Kpelou Pali , Mouzou Essowè
Published: October 2024

Carbon-based electrodes have recently been most widely used in P-MFC due to their desirable properties such as biocompatibility, chemical stability, affordable price, corrosion resistance, and ease of regeneration. In general, carbon-based electrodes, particularly graphite, are produced using a complex process based on petroleum derivatives at very high temperatures. This study aims to produce electrodes from bio-pitch and charcoal powder as an alternative to graphite electrodes. The carbons used to manufacture the electrodes were obtained by the carbonisation of Robinia pseudoacacia and Azadirachta indica wood. These carbons were pulverised, sieved to 50 µm, and used as the raw materials for electrode manufacturing. The binder used was bio-pitch derived from coconut shells as the raw materials. The density and coking value of the bio-pitch revealed its potential as a good alternative to coal-tar pitch for electrode manufacturing. The electrodes were made by mixing 66.50% of each carbon powder and 33.50% of bio-pitch. The resulting mixture was moulded into a cylindrical tube 8 mm in diameter and 80 mm in length. The raw electrodes obtained were subjected to heat treatment at 800 °C or 1000 °C in an inert medium. The electrical resistivity obtained by the four-point method showed that N1000 has an electrical resistivity at least five times lower than all the electrodes developed and two times higher than that of G. Fourier-transform infrared spectroscopy (FTIR) was used to determine the compositional features of the samples and their surface roughness was characterised by atomic force microscopy (AFM). Charge transfer was determined by electrical impedance spectroscopy (EIS). The FTIR of the electrodes showed that N1000 has a spectrum that is more similar to that of G compared to the others. The EIS showed the high ionic mobility of the ions and therefore that N1000 has a higher charge transfer compared to G and the others. AFM analysis revealed that N1000 had the highest surface roughness in this study.
Modifying Microstructure and Improving Mechanical Properties of New Ti-Al-V Titanium Alloys via Fe Addition
Authors: Dai Guoqing , Gu Hai , Zhang Jie , Jiang Jie , Sun Jianhua , Sun Zhonggang
Published: October 2024

A comprehensive study was carried out to investigate the effects of Fe addition (0–0.9 wt.%) on the microstructure evolution and mechanical properties of Ti-6Al-4V alloys. The results indicate that Fe addition has a significant refinement effect on the microstructure of titanium alloys; specifically, 0.9 wt.% Fe addition can lead to a 47.37% decrease in the width of lamellar α. The modulus also decreases by 18.89% with the increase in the Fe content, being 91.40 GPa in Ti-6Al-4V-0.9Fe. And the microhardness and wear resistance are improved due to Fe addition. In addition, the constitutive equation of the Fe content and the elastic compliance coefficient were calculated, which can better describe the relationship between Fe addition and the elastic–plastic properties of titanium alloys. The slip systems’ activity during the deformation process was also discussed using the Schmid factor. It shows that Fe addition is beneficial for the activity of prismatic and pyramidal slip systems, especially in the {101¯0} <112¯0>, {101¯1} <112¯3>, and {112¯2} <112¯3> slip systems.
A Multi-Scale Model for Predicting Physically Short Crack and Long Crack Behavior in Metals
Authors: Yang Xing , Zhang Chunguo , Wu Panpan , Xu Anye , Ju Pengfei , Yang Dandan , Dong Zhonghong
Published: October 2024

The fatigue behavior of metal specimens is influenced by defects, material properties, and loading. This study aims to establish a multi-scale fatigue crack growth model that describes physically short crack (PSC) and long crack (LC) behavior. The model allows the calculation of crack growth rates for uniaxial loading at different stress ratios based on the material properties and specimen geometry. Furthermore, the model integrates the Gaussian distribution theory to consider material heterogeneity and the experimental measurement errors that cause fatigue scatter. The crack growth rate and fatigue life of metal specimens with different notch geometry were predicted. The curves generated by the multi-scale model were mainly consistent with the test data from the published literature at the PSC and LC stages.
Cold Consolidation of Pharmaceutical Waste Glass Powders Through Alkali Activation and Binder Jet 3D Printing
Authors: Elsayed Hamada , Gobbin Filippo , Barci Alberto , Bernardo Enrico , Colombo Paolo
Published: October 2024

The recent COVID-19 emergency has led to an impressive increase in the production of pharmaceutical vials. This has led to a parallel increase in the amounts of waste glass; manufacturers typically recover material from faulty containers by crushing, giving origin to an unrecyclable fraction. Coarse fragments are effectively reused as feedstock for glass melting; on the contrary, fine powders (<100 microns), contaminated by metal and ceramic particles due to the same crushing operations, are landfilled. Landfilling is also suggested for pharmaceutical containers after medical use. This study aims at proposing new opportunities for the recycling of fine glass particles, according to recent findings concerning alkali activation of pharmaceutical glass, combined with novel processing, i.e., binder jetting printing. It has already been shown that pharmaceutical glass, immersed in low-molarity alkaline solution (not exceeding 2.5 M NaOH), undergoes surface dissolution and hydration; cold consolidation is later achieved, upon drying at 40–60 °C, by a condensation reaction occurring at hydrated layers of adjacent particles. Binder jetting printing does not realize a full liquid immersion of the glass powders, as the attacking solution is selectively sprayed on a powder bed. Here, we discuss the tuning of key parameters, such as the molarity of the attacking solution (from 2.5 to 10 M) and the granulometry of the waste glass, to obtain stable printed blocks. In particular, the stability depends on the formation of bridges between adjacent particles consisting of strong T-O bonds (Si-O-Si, Al-O-Si, B-O-Si), while degradation products (concentrating Na ions) remain as a secondary phase, solubilized by immersion in boiling water. Such stability is achieved by operating at 5 M NaOH.
Seismic Performance of Precast Drift-Hardening Concrete Walls Connected by Grout–Sheath Duct
Authors: Che Jiayu , Yuan Shiyu , Sun Yuping
Published: October 2024

In order to find a suitable size of sheath duct and a reliable construction method for precast walls, a cast-in-place and five 1/2 scale precast drift-hardening concrete walls reinforced with weakly bonded ultra-high strength SBPDN rebars were fabricated and tested under reserved lateral load and constant compression. The experimental variables were the diameter of sheath ducts (45 mm, 100 mm, and 120 mm), embedded length (20d and 35d; d is the nominal diameter of SBPDN rebars), axial load ratio (0.075 and 0.15), and the construction method. The experimental observations, hysteresis behaviors, envelope curves, residual deformation, crack propagation, and energy dissipation were compared in the study. Moreover, a formula was applied to calculate the bond strength of the sheath duct. The experimental and calculated results revealed that increasing the axial load ratio and embedment length could not enhance the bond strength of the sheath ducts, and increasing the diameter decreased the bond strength significantly. Anchored the SBPDN rebars in smaller sheath ducts separately was a more stable connection method for precast concrete shear walls and provided sufficient drift-hardening capability, even at a large drift level (over 3%).
Visual-Inertial Fusion-Based Five-Degree-of-Freedom Motion Measurement System for Vessel-Mounted Cranes
Authors: Yu Boyang , Cheng Yuansheng , Xia Xiangjun , Liu Pengfei , Ning Donghong , Li Zhixiong
Published: October 2024

Vessel-mounted cranes operate in complex marine environments, where precise measurement of cargo positions and attitudes is a key technological challenge to ensure operational stability and safety. This study introduces an integrated measurement system that combines vision and inertial sensing technologies, utilizing a stereo camera and two inertial measurement units (IMUs) to capture cargo motion in five degrees of freedom (DOF). By merging data from the stereo camera and IMUs, the system accurately determines the cargo’s position and attitude relative to the camera. The specific methodology is introduced as follows: First, the YOLO model is adopted to identify targets in the image and generate bounding boxes. Then, using the principle of binocular disparity, the depth within the bounding box is calculated to determine the target’s three-dimensional position in the camera coordinate system. Simultaneously, the IMU measures the attitude of the cargo, and a Kalman filter is applied to fuse the data from the two sensors. Experimental results indicate that the system’s measurement errors in the x, y, and z directions are less than 2.58%, 3.35%, and 3.37%, respectively, while errors in the roll and pitch directions are 3.87% and 5.02%. These results demonstrate that the designed measurement system effectively provides the necessary motion information in 5-DOF for vessel-mounted crane control, offering new approaches for pose detection of marine cranes and cargoes.
Unmanned Ground Vehicles for Continuous Crop Monitoring in Agriculture: Assessing the Readiness of Current ICT Technology
Authors: Agelli Maurizio , Corona Nicola , Maggio Fabio , Moi Paolo Vincenzo
Published: October 2024

Continuous crop monitoring enables the early detection of field emergencies such as pests, diseases, and nutritional deficits, allowing for less invasive interventions and yielding economic, environmental, and health benefits. The work organization of modern agriculture, however, is not compatible with continuous human monitoring. ICT can facilitate this process using autonomous Unmanned Ground Vehicles (UGVs) to navigate crops, detect issues, georeference them, and report to human experts in real time. This review evaluates the current state of ICT technology to determine if it supports autonomous, continuous crop monitoring. The focus is on shifting from traditional cloud-based approaches, where data are sent to remote computers for deferred processing, to a hybrid design emphasizing edge computing for real-time analysis in the field. Key aspects considered include algorithms for in-field navigation, AIoT models for detecting agricultural emergencies, and advanced edge devices that are capable of managing sensors, collecting data, performing real-time deep learning inference, ensuring precise mapping and navigation, and sending alert reports with minimal human intervention. State-of-the-art research and development in this field suggest that general, not necessarily crop-specific, prototypes of fully autonomous UGVs for continuous monitoring are now at hand. Additionally, the demand for low-power consumption and affordable solutions can be practically addressed.
A Preisach Model Defining Correlation Between Monotonic and Cyclic Response of Structural Mild Steel
Authors: Knežević Petar , Radaković Aleksandar , Velimirović Nikola , Čukanović Dragan , Perović Zoran , Radulović Rada , Bogdanović Gordana
Published: October 2024

This article delivers a new Preisach model representing the correlation between the elastoplastic behavior of structural mild steel under axial monotonic and cyclic loading with damage. The newly formed model is based on the experimentally defined correlation between axial monotonic and cyclic behavior of structural mild steel. To examine the monotonic and cyclic behavior of structural mild steel and find fitting material properties for the model, monotonic and cyclic axial tensile tests are performed. Tests are executed on coupons of the commonly used European structural steel S275. The model represents a mathematical description of modified single-crystal material behavior under monotonic loading. Two different approaches were used to describe damage in the multilinear mechanical model. The excellent agreement with experimental results is achieved by infinitely linking many single-crystal elements in parallel, forming the polycrystalline model. This model provides a good solution for everyday engineering practice due to its geometric representation in the form of the Preisach triangle and the lower costs of monotonic tests used to define material properties compared to cyclic tests.
Formation of Graded TiO2 Layer on Ti Wire by Direct Alternating Current Discharge Plasma at Atmospheric Pressure
Authors: Watanabe Yoshimi , Mitsuishi Naho , Yamada Motoko , Sato Hisashi , Takashima Seigo , Miura-Fujiwara Eri
Published: October 2024

Although metallic materials have been used as load-bearing materials in dental and biomedical fields since they have good mechanical properties such as good ductility and strength, their aesthetic properties are inferior to those of ceramic or resin. To obtain aesthetically improved Ti dental devices, the formation of white titanium oxide on pure Ti dental devices was studied. Direct atmospheric pressure plasma (APP) treatment using alternating current was carried out on pure a Ti plate and wire. It was found that a titanium oxide layer with enough whiteness can be obtained on pure Ti wire using direct APP treatment. Although delamination of the titanium oxide layer was found after a bending test, the concept of functionally graded materials (FGMs) can overcome the shortcoming.
Frequency–Time Domain Analysis Based on Electrochemical Noise of Dual-Phase (DP) and Ferrite–Bainite (FB) Steels in Chloride Solutions for Automotive Applications
Authors: Almeraya-Calderón Facundo , Montoya-Rangel Marvin , Nieves-Mendoza Demetrio , Jáquez-Muñoz Jesús Manuel , Baltazar-Zamora Miguel Angel , Landa-Ruiz Laura , Lara-Banda Maria , Maldonado-Bandala Erick , Estupiñan-Lopez Francisco , Gaona-Tiburcio Citlalli
Published: October 2024

The automotive industry uses high-strength (HS), low-alloy (HSLA) steels and advanced high-strength steels (AHSSs) to manufacture front and rear rails and safety posts, as well as the car body, suspension, and chassis components of cars. These steels can be exposed to corrosive environments, such as in countries where de-icing salts are used. This research aims to characterize the corrosion behavior of AHSSs based on electrochemical noise (EN) [dual-phase (DP) and ferrite–bainite (FB)]. At room temperature, the steels were immersed in NaCl, CaCl2, and MgCl2 solutions and were studied by frequency–time domain analysis using wavelet decomposition, Hilbert–Huang analysis, and recurrence plots (RPs) related to the corrosion process and noise impedance (Zn). Optical microscopy (OM) was used to observe the microstructure of the tested samples. The results generally indicated that the main corrosion process is related to uniform corrosion. The corrosion behavior of AHSSs exposed to a NaCl solution could be related to the morphology of the phase constituents that are exposed to solutions with chlorides. The Zn results showed that DP780 presented a higher corrosion resistance with 918 Ω·cm2; meanwhile, FB780 presented 409 Ω·cm2 when exposed to NaCl. Also, the corrosion mechanism of materials begins with a localized corrosion process spreading to all the surfaces, generating a uniform corrosion process after some exposition time.
Reconfigurable Multifunctional Metasurfaces for Full-Space Electromagnetic Wave Front Control
Authors: Zhang Shunlan , Cao Weiping , Wang Jiao , Wu Tiesheng , Wang Yiying , Wang Yanxia , Zhou Dongsheng
Published: October 2024

In order to implement multiple electromagnetic (EM) wave front control, a reconfigurable multifunctional metasurface (RMM) has been investigated in this paper. It can meet the requirements for 6G communication systems. Considering the full-space working modes simultaneously, both reflection and transmission modes, the flexible transmission-reflection-integrated RMM with p-i-n diodes and anisotropic structures is proposed. By introducing a 45°-inclined H-shaped AS and grating-like micro-structure, the polarization conversion of linear to circular polarization (LP-to-CP) is achieved with good angular stability, in the transmission mode from top to bottom. Meanwhile, reflection beam patterns can be tuned by switching four p-i-n diodes to achieve a 1-bit reflection phase, which are embedded in the bottom of unit cells. To demonstrate the multiple reconfigurable abilities of RMMs to regulate EM waves, the RMMs working in polarization conversion mode, transmitted mode, reflected mode, and transmission-reflection-integrated mode are designed and simulated. Furthermore, by encoding two proper reflection sequences with 13×13 elements, reflection beam patterns with two beams and four beams can be achieved, respectively. The simulation results are consistent with the theoretical method. The suggested metasurface is helpful for radar and wireless communications because of its compact size, simple construction, angular stability, and multi-functionality.
An Automated Digital Microfluidic System Based on Inkjet Printing
Authors: Hu Wansheng , Cao Ming , Liao Lingni , Liao Yuanhong , He Yuhan , Ma Mengxiao , Wang Simao , Guan Yimin
Published: October 2024

Cellular interactions, such as intercellular communication and signal transduction, can be enhanced within three-dimensional cell spheroids, contributing significantly to cellular viability and proliferation. This is crucial for advancements in cancer research, drug testing, and personalized medicine. The dimensions of the cell spheroids play a pivotal role in their functionality, affecting cell proliferation and differentiation, intercellular interactions, gene expression, protein synthesis, drug penetration, and metabolism. Consequently, different spheroid sizes may be required for various drug sensitivity experiments. However, conventional 3D cell spheroid cultures suffer from challenges such as size inconsistency, poor uniformity, and low throughput. To address these issues, we have developed an automated, intelligent system based on inkjet printing. This system allows for precise control of droplet volume by adjusting algorithms, thereby enabling the formation of spheroids of varying sizes. For spheroids of a single size, the printing pattern can be modified to achieve a coefficient of variation within 10% through a bidirectional compensation method. Furthermore, the system is equipped with an automatic pipetting module, which facilitates the high-throughput preparation of cell spheroids. We have implemented a 3 × 3 spheroid array in a 24-well plate, printing a total of 216 spheroids in just 11 min. Last, we attempted to print mouse small intestinal organoids and cultured them for 7 days, followed by immunofluorescent staining experiments. The results indicate that our equipment is capable of supporting the culture of organoids, which is of great significance for high-throughput drug screening and personalized medicine.
Optimal Design and Analysis of Wide-Band Near-Infrared Hybrid Dielectric Gratings with High Transmission Efficiency
Authors: Wang Ye , Chen Yongyi , Qin Li , Wang Lijun
Published: October 2024

Since surface relief transmission gratings have very strict requirements on operators and use environment, according to the semiconductor laser external cavity spectral beam combining system, this paper proposes a design scheme for a semiconductor laser array spectral beam combining system based on the grating-external cavity. The finite element approach was used to create a wideband, high-efficiency fill-in multilayer dielectric transmission grating structure for a high-power spectrum beam combining system. The incidence angle, ridge height, duty cycle, and sidewall inclination angle of the transmission grating were tuned and evaluated, and a link between the transmission grating’s diffraction efficiency and grating characteristics was discovered. The calculated design of the high-power fused silica transmission grating has a negative first-order peak diffraction efficiency of 99.5% in the 800 nm range. In the spectral region of 765–872 nm, the transmission grating’s diffraction effectiveness exceeds 92%. The filled ultra-high diffraction efficiency multilayer dielectric transmission grating design addresses the issue of resistance to high-power lasers under complicated operating settings. It is intended to maintain a high diffraction efficiency even after several cleaning cycles, and it is an ideal component for high-power spectrum beam combining systems.
Correction: Avetissian et al. A Novel Piezoelectric Energy Harvester for Earcanal Dynamic Motion Exploitation Using a Bistable Resonator Cycled by Coupled Hydraulic Valves Made of Collapsed Flexible Tubes. Micromachines 2024, 15, 415
Authors: Avetissian Tigran , Formosa Fabien , Badel Adrien , Delnavaz Aidin , Voix Jérémie
Published: October 2024

In the original publication [...]
Investigating the Potential of L(+)-Lactic Acid as a Green Inhibitor and Eradicator of a Dual-Species Campylobacter spp. Biofilm Formed on Food Processing Model Surfaces
Authors: Kostoglou Dimitra , Apostolopoulou Martha , Lagou Athina , Didos Spyros , Argiriou Anagnostis , Giaouris Efstathios
Published: October 2024

Campylobacter spp. are prevalent foodborne bacterial enteric pathogens. Their inclusion in biofilms on abiotic surfaces is considered a strategy that facilitates their extraintestinal survival. Organic acid (OA) treatments could be used in a green approach to decontaminate various surfaces. This work aimed to evaluate the inhibitory and eradicative effects of L(+)-lactic acid (LA), a naturally occurring OA, on a dual-species biofilm formed on two food processing model surfaces (polystyrene and stainless steel) by three selected foodborne Campylobacter spp. isolates (two C. jejuni and one C. coli). The influence of aerobiosis conditions (microaerophilic, aerobic and CO2 enriched) on the resistance of the established biofilms to the acid was also tested. In parallel, the predominant metabolites contained in the planktonic media of biofilm monocultures and mixed-culture biofilm were comparatively analyzed by an untargeted metabolomics approach. Results revealed that LA inhibited mixed-culture biofilm formation by more than 2 logs (>99%) on both surfaces when this was applied at its highest tested concentration (4096 μg/mL; 0.34% v/v). However, all the preformed mixed-culture biofilms (ca. 106−7 CFU/cm2) could not be eradicated even when the acid was used at concentrations exceeding 5% v/v, denoting their extremely high recalcitrance which was still influenced by the abiotic substratum, and the biofilm-forming aerobiosis conditions. The metabolic analysis revealed a strain-specific metabolite production which might also be related to the strain-specific biofilm-forming and resistance behaviors and resulted in the distinct clustering of the different samples. Overall, the current findings provide important information on the effectiveness of LA against biofilm campylobacteria and may assist in mitigating their risk in the food chain.
The Sources of Ore-Forming Materials and Fluids for the Jinqingding Gold Deposit in the Mouping–Rushan Metallogenic Belt, Jiaodong Peninsula: Evidence from S-H-O Isotopes and Trace Elements in Pyrite
Authors: Huang Xin , Sun Deyou , Yu Song , Wang Yongjun , Shen Lijun , Shao Yubao , Lu Changyong , Song Qian , Xiao Tingting
Published: October 2024

The Jinqingding gold deposit, characterized as an extra-large quartz-vein-type deposit, is located in the middle of the Mouping–Rushan metallogenic belt in the Jiaodong Peninsula, and there is still controversy over its sources of ore-forming materials and fluids. This paper divides the mineralization of Jinqinding gold deposits into four stages, based on a field geological investigation and indoor petrographic observations: (1) coarse-grained pyrite–quartz stage, (2) quartz–fine-grained pyrite stage, (3) quartz–polymetallic sulfide stage, and (4) quartz–carbonate stage. The quartz fluid inclusions showed δD values of −96.0 to −81.8‰ and δOV-SMOW values of 0.70 to 6.32‰, indicating that the ore-forming fluids were mainly magmatic water, with some metamorphic water and atmospheric precipitation. The in situ δ34S values in different subzones of the pyrites of the Jinqingding gold deposit range from 6.69 to 10.86‰. The δ34S value range of the Jinqingding gold deposit is basically consistent with the contemporaneous intermediate–basic dikes in the region, suggesting a shared material source. In situ LA-ICP-MS geochemical analyses of the pyrites show large variations of Co/Ni ratios (0.21 to 99.5), which suggest a hydrothermal origin for the gold deposit. We infer that the ore-forming fluid of the Jinqingding gold deposit originated from the magma from the upper mantle and the mantle–crust transition zone.
Exploiting the Bragg Mirror Effect of TiO2 Nanotube Photonic Crystals for Promoting Photoelectrochemical Water Splitting
Authors: Meng Ming , Zhou Hucheng , Yang Jing , Wang Liwei , Yuan Honglei , Hao Yanling , Gan Zhixing
Published: October 2024

Exploiting the Bragg mirror effect of photonic crystal photoelectrode is desperately desired for photoelectrochemical water splitting. Herein, a novel TiO2 nanotube photonic crystal bi-layer structure consisting of a top nanotube layer and a bottom nanotube photonic crystal layer is presented. In this architecture, the photonic bandgap of bottom TiO2 nanotube photonic crystals can be precisely adjusted by modulating the anodization parameters. When the photonic bandgap of bottom TiO2 nanotube photonic crystals overlaps with the electronic bandgap of TiO2, the bottom TiO2 nanotube photonic crystal layer will act as a Bragg mirror, leading to the boosted ultraviolet light absorption of the top TiO2 nanotube layer. Benefiting from the promoted UV light absorption, the TiO2 NT-115-NTPC yields a photocurrent density of 1.4 mA/cm2 at 0.22 V vs. Ag/AgCl with a Faradic efficiency of 100%, nearly two times higher than that of conventional TiO2 nanotube arrays. Furthermore, incident photon-to-current conversion efficiency is also promoted within ultraviolet light region. This research offers an effective strategy for improving the performance of photoelectrochemical water splitting through intensifying the light–matter interaction.
A Systematic Review of the Effect of Polyphenols on Alterations of the Intestinal Microbiota and Shared Bacterial Profiles Between Metabolic Syndrome and Acne
Authors: Ilari Sara , Nucera Saverio , Morabito Lucrezia , Caminiti Rosamaria , Mazza Valeria , Ritorto Giovanna , Ussia Sara , Passacatini Lucia Carmela , Macrì Roberta , Scarano Federica , Serra Maria , Scali Elisabetta , Maiuolo Jessica , Oppedisano Francesca , Palma Ernesto , Muscoli Saverio , Proietti Stefania , Tomino Carlo , Mollace Vincenzo , Muscoli Carolina
Published: October 2024

Introduction: Microbiota, composed of micro-organisms like bacteria, viruses, and non-pathogenic fungi, plays a crucial role in digestion, vitamin production, and protection against dangerous microbes. Several factors, including age, diet, alcohol consumption, stress, environmental microorganisms, and therapies (particularly antibiotics), as well as birth and nursing, could modify the microbiota. Recent research has highlighted its alteration and involvement in a various disease, including metabolic syndrome and acne. This systematic review aimed to identify common biomarkers and microbiota alterations shared between metabolic syndrome and acne, and to explore how the potential prebiotic activities of polyphenols may promote intestinal eubiosis. Materials and methods: A comprehensive search in PubMed and EMBASE resulted in 4142 articles, from which nine studies were selected based on specific criteria after removing duplicates and reviewing abstracts and full texts. All studies correlated the microbiota alteration in both pathologies and the activity of polyphenols in metabolic syndrome. Results: This review suggests that acne may be influenced by some of the same microorganisms involved in metabolic syndrome. While the literature highlights the effectiveness of polyphenols in treating metabolic syndrome, no studies have yet demonstrated their specific impact on acne. Conclusions: The research points to the potential benefits of polyphenols in modulating the microbiota, which could be relevant for individuals with metabolic syndrome. However, due to the limited data available, it was not possible to establish a direct correlation between metabolic syndrome and acne.
Loss of Bone Density in Patients with Anorexia Nervosa Food That Alone Will Not Cure
Authors: Gibson Dennis , Filan Zoe , Westmoreland Patricia , Mehler Philip S.
Published: October 2024

Background: Anorexia Nervosa is a highly lethal illness that is also associated with many medical complications. Food restriction and weight loss define this illness. Most of its physical complications are reversible with weight restoration, with the notable exception of the loss of bone density, which is commonly present in anorexia nervosa. Methods: A comprehensive scientific literature review was performed in order to explore bone disease in anorexia nervosa. Results: The pathophysiology of the loss of bone mineral density in anorexia nervosa was elucidated, along with the diagnosis and treatment of osteoporosis in patients with anorexia nervosa, including the nutritional approach to weight restoration. Conclusions: Loss of bone mineral density in anorexia nervosa is very aggressive. Nutritional rehabilitation is a cornerstone to treating this, along with medicinal considerations.
Factors Associated with Carbohydrate Counting Adherence in Adults with Type 1 Diabetes Mellitus in Brazil
Authors: Uliana Gabriela Correia , Silva Sarah Emili Cruz da , Carvalhal Manuela Maria de Lima , Paracampo Carla Cristina Paiva , Gomes Daniela Lopes
Published: October 2024

Background: Carbohydrate Counting (CC) is important in managing the treatment of Type 1 Diabetes Mellitus (T1DM). This study aimed to evaluate the factors associated with adherence to CC in adults with T1DM in Brazil. Methods: A cross-sectional study was conducted through an online questionnaire. Information was collected on sociodemographic, economic, clinical, and anthropometric factors; knowledge of the CC strategy; the acquisition of supplies; the perception of mathematical skills as a hurdle in adhering to CC; and follow-up with healthcare professionals. Pearson’s chi-squared or Fisher’s exact test was applied (p < 0.05). Results: Of the 173 participants, 72.8% practiced CC. Practicing CC was associated with having an income higher than three minimum wage equivalents (p = 0.023), and not practicing CC due to the lack of supplies for glucose monitoring was associated with having practiced CC at some point but is currently not practicing (p < 0.001). Not practicing the necessary calculations for CC was associated with “knowing how to do CC but had never done it” and “had done CC at some point but currently not practicing” (p < 0.001). Stopping or having stopped practicing CC due to insufficient materials for glucose monitoring was associated with having practiced CC for a period but is not currently doing so (p < 0.001). Following up with healthcare professionals (p < 0.001) and receiving encouragement from the endocrinologist (p < 0.001) and nutritionist (p = 0.047) were associated with adherence to CC. Conclusions: Having a better financial status, performing the mathematical calculations required for CC, having access to supplies for glucose monitoring, and receiving specialized professional follow-up were factors associated with adherence to CC in Brazil.
Palmitoleic Acid Inhibits Hepatotoxic Effects by Reducing Trimethylamine-N-Oxide (TMAO) Formation in High L-Carnitine-Treated Mice
Authors: Han Qingzheng , Liu Yu , Liu Xinyu , Geng Yue , Wu Qiu , Xiao Hang
Published: October 2024

Background/Objectives: This study investigated the effects of palmitoleic acid (POA) consumption on liver function, intestinal microbiota, and trimethylamine-N-oxide (TMAO) levels in the serum of mice treated with 3% L-carnitine drinking water. The purpose was to highlight the impact of POA on liver injury associated with high L-carnitine intake. Methods: A correlation analysis was carried out. The physiological and biochemical results showed that the administration of POA could alleviate liver injury induced by high L-carnitine ingestion, as reflected by a reduction in liver function indices (ALT, AST, AKP, and TBA activities) and modulation of antioxidant enzyme activities (SOD, GSH-Px, MDA, and RAHFR). The study also monitored the levels of total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Additionally, to assess the impact of POA on intestinal microbiota, we conducted a 16S rRNA high-throughput sequencing analysis. Results: The findings indicated that POA administration resulted in lower levels of TMAO in treated mice. Furthermore, POA could regulate the composition of intestinal microbiota in L-carnitine mice, particularly affecting Bacteroides vulgatus, Parabacteroides distasonis, Alistipes shahii, Lachnospiraceae NK4A136 group, and Parasutterella secunda, which were closely related to liver injury. Conclusions: In summary, POA could repair liver damage caused by high intake of L-carnitine by regulating the distribution of intestinal flora and subsequently decreasing serum TMAO levels.
Short-Term Effects of Escalating Doses of Cholecalciferol on FGF23 and 24,25(OH)2 Vitamin D Levels: A Preliminary Investigation
Authors: Pepe Jessica , Colangelo Luciano , Pilotto Roberta , De Martino Viviana , Ferrara Carla , Scillitani Alfredo , Cilli Mirella , Minisola Salvatore , Singh Ravinder , Cipriani Cristiana
Published: October 2024

Background: There are few and controversial results on 24,25(OH)2D and FGF23 acute changes following supplementation with cholecalciferol. Methods: Twenty-seven subjects with 25(OH)D < 30 ng/mL were randomized into three groups to receive a single oral dose of 25,000 I.U. or 600,000 I.U. of cholecalciferol or placebo, respectively. We measured 25(OH)D, 1,25(OH)2D, 24,25(OH)2D, and FGF23 levels at baseline and after 72 h. The 1,25(OH)2D/25(OH)D, 1,25(OH)2D/24,25(OH)2D, and 24,25(OH)2D/25(OH)D ratios were also calculated. Results: There was an increase in 25(OH)D and 1,25 (OH)2D following both doses of cholecalciferol. In the group administered 600,000 I.U., there was a significant increase in the delta changes in 25(OH)D and 1,25(OH)2D compared to the placebo and in the delta 24,25(OH)D2 compared to the placebo and 25,000 I.U. groups (all p < 0.05). A decrease in both the 1,25(OH)2D/25(OH)D and 1,25(OH)2D/24,25(OH)2D ratio (all p < 0.05) was observed in the 600,000 I.U. group. FGF23 values significantly increased only in the group administered 600,000 I.U. Conclusions: 25(OH)D and 1,25(OH)D levels significantly increased following 600,000 IU cholecalciferol administration compared to 25,000 I.U. and placebo. Following the massive administration of cholecalciferol, the CYP24A1 enzyme is actively involved in catabolism, thus, avoiding toxic effects.