bluuebunny/crossref_metadata_2025 huggingface dataset:
The Janus Kinase Inhibitor Ruxolitinib Prevents Terminal Shock in a Mouse Model of Arenavirus Hemorrhagic Fever
Authors: Sahin Mehmet , Remy Melissa M. , Merkler Doron , Pinschewer Daniel D.
Published: March 2021

Arenaviruses such as Lassa virus cause arenavirus hemorrhagic fever (AVHF), but protective vaccines and effective antiviral therapy remain unmet medical needs. Our prior work has revealed that inducible nitric oxide synthase (iNOS) induction by IFN-γ represents a key pathway to microvascular leak and terminal shock in AVHF. Here we hypothesized that Ruxolitinib, an FDA-approved JAK inhibitor known to prevent IFN-γ signaling, could be repurposed for host-directed therapy in AVHF. We tested the efficacy of Ruxolitinib in MHC-humanized (HHD) mice, which develop Lassa fever-like disease upon infection with the monkey-pathogenic lymphocytic choriomeningitis virus strain WE. Anti-TNF antibody therapy was tested as an alternative strategy owing to its expected effect on macrophage activation. Ruxolitinib but not anti-TNF antibody prevented hypothermia and terminal disease as well as pleural effusions and skin edema, which served as readouts of microvascular leak. As expected, neither treatment influenced viral loads. Intriguingly, however, and despite its potent disease-modifying activity, Ruxolitinib did not measurably interfere with iNOS expression or systemic NO metabolite levels. These findings suggest that the FDA-approved JAK-inhibitor Ruxolitinib has potential in the treatment of AVHF. Moreover, our observations indicate that besides IFN-γ-induced iNOS additional druggable pathways contribute essentially to AVHF and are amenable to host-directed therapy.
Identification of New Potential Biotherapeutics from Human Gut Microbiota-Derived Bacteria
Authors: Cuffaro Bernardo , Assohoun Aka L. W. , Boutillier Denise , Peucelle Véronique , Desramaut Jérémy , Boudebbouze Samira , Croyal Mikael , Waligora-Dupriet Anne-Judith , Rhimi Moez , Grangette Corinne , Maguin Emmanuelle
Published: March 2021

The role of the gut microbiota in health and disease is well recognized and the microbiota dysbiosis observed in many chronic diseases became a new therapeutic target. The challenge is to get a better insight into the functionality of commensal bacteria and to use this knowledge to select live biotherapeutics as new preventive or therapeutic products. In this study, we set up a screening approach to evaluate the functional capacities of a set of 21 strains isolated from the gut microbiota of neonates and adults. For this purpose, we selected key biological processes involved in the microbiome-host symbiosis and known to impact the host physiology i.e., the production of short-chain fatty acids and the ability to strengthen an epithelial barrier (Caco-2), to induce the release of the anti-inflammatory IL-10 cytokine after co-culture with human immune cells (PBMC) or to increase GLP-1 production from STC-1 endocrine cell line. This strategy highlighted fifteen strains exhibiting beneficial activities among which seven strains combined several of them. Interestingly, this work revealed for the first time a high prevalence of potential health-promoting functions among intestinal commensal strains and identified several appealing novel candidates for the management of chronic diseases, notably obesity and inflammatory bowel diseases.
Environmental Aspect of the Cement Manufacturing in the Świętokrzyskie Mountains (Southeastern Poland)
Authors: Kozłowski Rafał , Szwed Mirosław , Żelezik Monika
Published: March 2021

The research area located in south-eastern Poland is exposed to alkaline pressure from a cement plant in Nowiny, which has been operating there since 1960. Both biotic and abiotic components of the natural environment remain in the zone of the plant’s negative impact. Their reaction, described according to the concept of geo- and bioindicators, provides valuable information on the state of the natural environment in this area. In 2016–2018, the properties of precipitation were being investigated by determining its pH, EC (specific electrolytic conductivity), and chemical composition in terms of the presence of selected heavy metals. Additionally, the chemical composition of samples of two-year-old pine needles, bark, and wood, as well as soil taken from the immediate vicinity of the cement plant, was analyzed. The analysis performed using the Inductively Coupled Plasma-Mass Spectrometer-Time-of-Flight (ICP-MS-TOF) showed the presence of heavy metals. The highest contents were recorded in soils (Pb 123 mg·kg−1; Cr 138 mg·kg−1; Cu 18 mg·kg−1; Zn 699 mg·kg−1), while the lowest ones were found in the wooden cores of drilled trees (Pb 0.1 mg·kg−1; Cr 1 mg·kg−1; Cu 0.1 mg·kg−1; Zn 4.1 mg·kg−1). On the basis of the research conducted on precipitation, it was found that the pH and EC values were increased, and the presence of heavy metals (Pb, Cr, Ni, and Cu) indicating a local source of pollution was indicated.
Rietveld Study of the Changes of Phase Composition, Crystal Structure, and Morphology of BiFeO3 by Partial Substitution of Bismuth with Rare-Earth Ions
Authors: Kireva Maria , Tumbalev Ventsislav , Kostov-Kytin Vladislav , Tzvetkov Peter , Kovacheva Daniela
Published: March 2021

BiFeO3 is an interesting material due to its multiferroic properties. It attracts attention due to its potential applications in spintronics and in microelectronics for data storage, among others. Single-phase bulk material from BiFeO3 is difficult to synthesize. The kinetics of perovskite phase formation most often leads to the presence of impurity phases. It has been shown that low levels of replacement of Bi with rare earth ions lead to stabilization of the perovskite phase. In the present work, Rietveld refinement of the crystal structure based on powder X-ray diffraction patterns was applied to study the influence of partial substitution of Bi by rare-earth (RE) elements with different ionic radii on structural and morphological properties of the ferrite phase. Substitution by large RE ions was found to preserve the rhombohedral symmetry of BiFeO3, whereas substitution by smaller RE ions led to the coexistence of two polymorphic perovskite phases with rhombohedral R3c and orthorhombic Pnma symmetries. The unit cell parameters as well as the interatomic distances and angles, not only around the A cation but also around the iron ions, were influenced by the substitution. The mean crystallite and particle size decreased with the decrease of ionic radius of substituting RE ion.
A Petrologic and Noble Gas Isotopic Study of New Basaltic Eucrite Grove Mountains 13001 from Antarctica
Authors: Zhang Chuantong , Miao Bingkui , He Huaiyu , Chen Hongyi , Ranjith P. M. , Xie Qinglin
Published: March 2021

Howardite-Eucrite-Diogenite (HED) meteorite clan is a potential group of planetary materials which provides significant clues to understand the formation and evolution of the solar system. Grove Mountains (GRV) 13001 is a new member of HED meteorite, recovered from the Grove Mountains of Antarctica by the Chinese National Antarctic Research Expedition. This research work presents a comprehensive study of the petrology and mineralogy, chemical composition, noble gas isotopes, cosmic-ray exposure (CRE) age and nominal gas retention age for the meteorite GRV 13001. The output data indicate that GRV 13001 is a monomict basaltic eucrite with typical ophitic/subophitic texture, and it consists mainly of low-Ca pyroxene and plagioclase with normal eucritic chemical compositions. The noble gas based CRE age of the GRV 13001 is approximately 29.9 ± 3.0 Ma, which deviates from the major impact events or periods on the HED parent body. Additionally, the U,Th-4He and 40K-40Ar gas retention ages of this meteorite are ~2.5 to 4.0 Ga and ~3.6 to 4.1 Ga, respectively. Based on the noble gases isotopes and the corresponding ages, GRV 13001 may have experienced intense impact processes during brecciation, and weak thermal event after the ejection event at approximately 30 Ma.
6FDA-DAM:DABA Co-Polyimide Mixed Matrix Membranes with GO and ZIF-8 Mixtures for Effective CO2/CH4 Separation
Authors: Jain Anand , Ahmad Mohd Zamidi , Linkès Audrey , Martin-Gil Violeta , Castro-Muñoz Roberto , Izak Pavel , Sofer Zdeněk , Hintz Werner , Fila Vlastimil
Published: March 2021

This work presents the gas separation evaluation of 6FDA-DAM:DABA (3:1) co-polyimide and its enhanced mixed matrix membranes (MMMs) with graphene oxide (GO) and ZIF-8 (particle size of <40 nm). The 6FDA-copolyimide was obtained through two-stage poly-condensation polymerization, while the ZIF-8 nanoparticles were synthesized using the dry and wet method. The MMMs were preliminarily prepared with 1–4 wt.% GO and 5–15 wt.% ZIF-8 filler loading independently. Based on the best performing GO MMM, the study proceeded with making MMMs based on the mixtures of GO and ZIF-8 with a fixed 1 wt.% GO content (related to the polymer matrix) and varied ZIF-8 loadings. All the materials were characterized thoroughly using TGA, FTIR, XRD, and FESEM. The gas separation was measured with 50:50 vol.% CO2:CH4 binary mixture at 2 bar feed pressure and 25 °C. The pristine 6FDA-copolyimide showed CO2 permeability (PCO2) of 147 Barrer and CO2/CH4 selectivity (αCO2/CH4) of 47.5. At the optimum GO loading (1 wt.%), the PCO2 and αCO2/CH4 were improved by 22% and 7%, respectively. A combination of GO (1 wt.%)/ZIF-8 fillers tremendously improves its PCO2; by 990% for GO/ZIF-8 (5 wt.%) and 1.124% for GO/ZIF-8 (10 wt.%). Regrettably, the MMMs lost their selectivity by 16–55% due to the non-selective filler-polymer interfacial voids. However, the hybrid MMM performances still resided close to the 2019 upper bound and showed good performance stability when tested at different feed pressure conditions.
Hydrophobic/Oleophilic Structures Based on MacroPorous Silicon: Effect of Topography and Fluoroalkyl Silane Functionalization on Wettability
Authors: Formentín Pilar , Marsal Lluís F.
Published: March 2021

The effect of the morphology and chemical composition of a surface on the wettability of porous silicon structures is analyzed in the present work. Hydrophobic and superhydrophobic macroporous substrates are attractive for different potential applications. Herein, different hydrophobic macroporous silicon structures were fabricated by the chemical etching of p-type silicon wafers in a solution based on hydrofluoric acid and coated with a fluoro silane self-assembled monolayer. The surface morphology of the final substrate was characterized using a scanning electron microscope. The wettability was assessed from contact angle measurements using water and organic solvents that present low surface energy. The experimental data were compared with the classical wetting states theoretical models described in the literature. Perfluoro-silane functionalized macroporous silicon surfaces presented systematically higher contact angles than untreated silicon substrates. The influence of porosity on the surface wettability of macoporous silicon structures has been established. These results suggest that the combination of etching conditions with a surface chemistry modification could lead to hydrophobic/oleophilic or superhydrophobic/oleophobic structures.
Scalable Production of Boron Quantum Dots for Broadband Ultrafast Nonlinear Optical Performance
Authors: Meng Shuolei , Chen Qianyuan , Lin Hongjian , Zhou Feng , Gong Youning , Pan Chunxu , Lu Shunbin
Published: March 2021

A simple and effective approach based on the liquid phase exfoliation (LPE) method has been put forward for synthesizing boron quantum dots (BQDs). By adjusting the interactions between bulk boron and various solvents, the average diameter of produced BQDs is about 7 nm. The nonlinear absorption (NLA) responses of as-prepared BQDs have been systematically studied at 515 nm and 1030 nm. Experimental results prove that BQDs possess broadband saturable absorption (SA) and good third-order nonlinear optical susceptibility, which are comparable to graphene. The fast relaxation time and slow relaxation time of BQDs at 515 nm and 1030 nm are about 0.394–5.34 ps and 4.45–115 ps, respectively. The significant ultrafast nonlinear optical properties can be used in optical devices. Here, we successfully demonstrate all-optical diode application based on BQDs/ReS2 tandem structure. The findings are essential for understanding the nonlinear optical properties in BQDs and open a new pathway for their applications in optical devices.
Nano-Photocatalytic Materials: Possibilities and Challenges
Authors: Doña-Rodríguez José M. , Pulido Melián Elisenda
Published: March 2021

Photocatalysis is one of the most promising processes within catalysis, due to its increasing potential and the possibility of its being combined with renewable solar energy [...]
Acute and Post-Acute Neurological Complications of COVID-19
Authors: Al-Ramadan Ali , Rabab’h Omar , Shah Jawad , Gharaibeh Abeer
Published: March 2021

Coronavirus disease 2019 (COVID-19) is an emerging global health emergency caused by the novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The global outbreak of SARS-CoV-2 infection has been declared a global pandemic by the World Health Organization (WHO). The clinical presentation of SARS-CoV-2 infection depends on the severity of the disease and may range from an asymptomatic infection to a severe and lethal illness. Fever, cough, and shortness of breath are among the most common symptoms associated with SARS-CoV-2 infection. Accumulating evidence indicates that COVID-19 patients commonly develop neurological symptoms, such as headache, altered mental status, anosmia, and myalgia. In this comprehensive literature review, we have summarized the most common neurological complications and reported neurological case studies associated with COVID-19, and neurological side effects associated with COVID-19 treatments. Additionally, the post-acute COVID-19 syndrome and long-term neurological complications were discussed. We also explained the proposed mechanisms that are involved in the pathogenesis of these neurological complications.
Rehydration during Endurance Exercise: Challenges, Research, Options, Methods
Authors: Armstrong Lawrence E.
Published: March 2021

During endurance exercise, two problems arise from disturbed fluid–electrolyte balance: dehydration and overhydration. The former involves water and sodium losses in sweat and urine that are incompletely replaced, whereas the latter involves excessive consumption and retention of dilute fluids. When experienced at low levels, both dehydration and overhydration have minor or no performance effects and symptoms of illness, but when experienced at moderate-to-severe levels they degrade exercise performance and/or may lead to hydration-related illnesses including hyponatremia (low serum sodium concentration). Therefore, the present review article presents (a) relevant research observations and consensus statements of professional organizations, (b) 5 rehydration methods in which pre-race planning ranges from no advanced action to determination of sweat rate during a field simulation, and (c) 9 rehydration recommendations that are relevant to endurance activities. With this information, each athlete can select the rehydration method that best allows her/him to achieve a hydration middle ground between dehydration and overhydration, to optimize physical performance, and reduce the risk of illness.
Invasive Candida Infections in Neonates after Major Surgery: Current Evidence and New Directions
Authors: De Rose Domenico , Santisi Alessandra , Ronchetti Maria , Martini Ludovica , Serafini Lisa , Betta Pasqua , Maino Marzia , Cavigioli Francesco , Cocchi Ilaria , Pugni Lorenza , Bonanno Elvira , Tzialla Chryssoula , Giuffrè Mario , Bua Jenny , Della Torre Benedetta , Nardella Giovanna , Mazzeo Danila , Manzoni Paolo , Dotta Andrea , Bagolan Pietro , Auriti Cinzia ,   on behalf of Study Group of Neonatal Infectious Diseases
Published: March 2021

Infections represent a serious health problem in neonates. Invasive Candida infections (ICIs) are still a leading cause of mortality and morbidity in neonatal intensive care units (NICUs). Infants hospitalized in NICUs are at high risk of ICIs, because of several risk factors: broad spectrum antibiotic treatments, central catheters and other invasive devices, fungal colonization, and impaired immune responses. In this review we summarize 19 published studies which provide the prevalence of previous surgery in neonates with invasive Candida infections. We also provide an overview of risk factors for ICIs after major surgery, fungal colonization, and innate defense mechanisms against fungi, as well as the roles of different Candida spp., the epidemiology and costs of ICIs, diagnosis of ICIs, and antifungal prophylaxis and treatment.
Aggressive Neuroblastoma in a Pediatric Patient with Severe Hemophilia A
Authors: Costa Lidia , Couto Maria Eduarda , Moutinho Juliana , Ferreira Ana Maia , Costa Emilia , Roncon Susana , Santos Luisa Lopes , Cruz Eugenia , Morais Sara
Published: March 2021

Despite the extensive information regarding hemophilia’s hemorrhagic complications, the literature on cancer in hemophilia is scarce, especially in pediatric patients. Many uncertainties remain concerning diagnosis and workup. We report a rare case of two severe diseases (neuroblastoma and hemophilia A (HA)) concomitantly present in the same pediatric patient. We highlight that the diagnosis of severe HA did not have a negative impact on the patient’s oncologic course. This case also illustrates the significance of the cooperation among different specialties and hospitals when caring for the same patient.
Cardiovascular and Respiratory Toxicity of Protamine Sulfate in Zebrafish and Rodent Models
Authors: Miklosz Joanna , Kalaska Bartlomiej , Podlasz Piotr , Chmielewska-Krzesińska Małgorzata , Zajączkowski Miłosz , Kosiński Adam , Pawlak Dariusz , Mogielnicki Andrzej
Published: March 2021

Protamine sulfate (PS) is the only available option to reverse the anticoagulant activity of unfractionated heparin (UFH), however it can cause cardiovascular and respiratory complications. We explored the toxicity of PS and its complexes with UFH in zebrafish, rats, and mice. The involvement of nitric oxide (NO) in the above effects was investigated. Concentration–dependent lethality, morphological defects, and decrease in heart rate (HR) were observed in zebrafish larvae. PS affected HR, blood pressure, respiratory rate, peak exhaled CO2, and blood oxygen saturation in rats. We observed hypotension, increase of HR, perfusion of paw vessels, and enhanced respiratory disturbances with increases doses of PS. We found no effects of PS on human hERG channels or signs of heart damage in mice. The hypotension in rats and bradycardia in zebrafish were partially attenuated by the inhibitor of endothelial NO synthase. The disturbances in cardiovascular and respiratory parameters were reduced or delayed when PS was administered together with UFH. The cardiorespiratory toxicity of PS seems to be charge–dependent and involves enhanced release of NO. PS administered at appropriate doses and ratios with UFH should not cause permanent damage of heart tissue, although careful monitoring of cardiorespiratory parameters is necessary.
Empowering Public Health Pharmacy Practice—Moving from Collaborative Practice Agreements to Provider Status in the U.S.
Authors: Cernasev Alina , Aruru Meghana , Clark Suzanne , Patel Komal , DiPietro Mager Natalie , Subramaniam Vaiyapuri , Truong Hoai-An
Published: March 2021

This article describes the history and evolution of pharmacist-physician collaborative practice agreements (CPAs) in the United States with future directions to support pharmacists’ provider status as the profession continues to evolve from product-oriented to patient-centered care and population health. The pharmacy profession has a long history of dispensing and compounding, with the addition of clinical roles in the late 20th century. These clinical roles have continued to expand into diverse arenas such as communicable and non-communicable diseases, antimicrobial stewardship, emergency preparedness and response, public health education and health promotion, and critical and emergency care. Pharmacists continue to serve as integral members of interprofessional and interdisciplinary healthcare teams. In this context, CPAs allow pharmacists to expand their roles in patient care and may be considered as a step towards securing provider status. Moving beyond CPAs to a provider status would enable pharmacists to be reimbursed for cognitive services and promote integrated public health delivery models.
The Validity of the Theory of Planned Behaviour for Understanding People’s Beliefs and Intentions toward Reusing Medicines
Authors: Alhamad Hamza , Donyai Parastou
Published: March 2021

Background: many factors can impact a person’s behaviour. When the behaviour is subject to prediction, these factors can include, for example, the perceived advantages and disadvantages of performing the behaviour, normative beliefs, and whether the behaviour is thought to be achievable. This paper examines intentions to engage in medicines reuse, i.e., to accept medicines that are returned unused to a pharmacy to be reused. The paper aims to outline the validity of the Theory of Planned Behaviour (TPB) for understanding people’s intentions to engage in medicines reuse by examining this against other long-standing health-related psychological theories of behavioural change. Thus, the Health Belief Model (HBM), Protection Motivation Theory (PMT), Trans-Theoretical Model of Health Behaviour Change (TTM/SoC), Theory of Reasoned Action (TRA), and TPB are examined for their application in the study of medicines reuse. Discussion: the HBM, PMT, TTM/SoC, TRA, and TPB were assessed for their relevance to examining medicines reuse as a behaviour. The validity of the TPB was justified for the development of a Medication Reuse Questionnaire (MRQ) to explore people’s beliefs and intention toward reusing medicines. Conclusion: TPB has been widely used inside and outside of health-related research and it was found to have more accurately defined constructs, making it helpful in studying medicines reuse behaviour.
Small Non-Coding RNAs at the Crossroads of Regulatory Pathways Controlling Somatic Embryogenesis in Seed Plants
Authors: Alves Ana , Cordeiro Daniela , Correia Sandra , Miguel Célia
Published: March 2021

Small non-coding RNAs (sncRNAs) are molecules with important regulatory functions during development and environmental responses across all groups of terrestrial plants. In seed plants, the development of a mature embryo from the zygote follows a synchronized cell division sequence, and growth and differentiation events regulated by highly regulated gene expression. However, given the distinct features of the initial stages of embryogenesis in gymnosperms and angiosperms, it is relevant to investigate to what extent such differences emerge from differential regulation mediated by sncRNAs. Within these, the microRNAs (miRNAs) are the best characterized class, and while many miRNAs are conserved and significantly represented across angiosperms and other seed plants during embryogenesis, some miRNA families are specific to some plant lineages. Being a model to study zygotic embryogenesis and a relevant biotechnological tool, we systematized the current knowledge on the presence and characterization of miRNAs in somatic embryogenesis (SE) of seed plants, pinpointing the miRNAs that have been reported to be associated with SE in angiosperm and gymnosperm species. We start by conducting an overview of sncRNA expression profiles in the embryonic tissues of seed plants. We then highlight the miRNAs described as being involved in the different stages of the SE process, from its induction to the full maturation of the somatic embryos, adding references to zygotic embryogenesis when relevant, as a contribution towards a better understanding of miRNA-mediated regulation of SE.
Review of the Most Important Methods of Improving the Processing Properties of Starch toward Non-Food Applications
Authors: Zarski Arkadiusz , Bajer Krzysztof , Kapuśniak Janusz
Published: March 2021

Starch is the second most abundantly available natural polymer in the world, after cellulose. If we add its biodegradability and non-toxicity to the natural environment, it becomes a raw material very attractive for the food and non-food industries. However, in the latter case, mainly due to the high hydrophilicity of starch, it is necessary to carry out many more or less complex operations and processes. One of the fastest growing industries in the last decade is the processing of biodegradable materials for packaging purposes. This is mainly due to awareness of producers and consumers about the dangers of unlimited production and the use of non-degradable petroleum polymers. Therefore, in the present review, an attempt was made to show the possibilities and limitations of using starch as a packaging material. The most important physicochemical features of this biopolymer are discussed, and special attention is paid to more or less environmentally friendly methods of improving its processing properties.
Optimal Design of a Fiber-Reinforced Plastic Composite Sandwich Structure for the Base Plate of Aircraft Pallets In Order to Reduce Weight
Authors: Al-Fatlawi Alaa , Jármai Károly , Kovács György
Published: March 2021

The application of fiber-reinforced plastic (FRP) composite materials instead of metals, due to the low density of FRP materials, results in weight savings in the base plates of aircraft pallets. Lower weight leads to lower fuel consumption of the aircraft and thereby less environmental damage. The study aimed to investigate replacing the currently used aluminum base plates of aircraft pallets with composite sandwich plates to reduce the weight of the pallets, thereby the weight of the unit loads transported by aircraft. The newly constructed sandwich base plate consists of an aluminum honeycomb core and FRP composite face-sheets. First, we made experimental tests and numerical calculations for the investigated FRP sandwich panel to validate the applicability of the calculation method. Next, the mechanical properties of 40 different layer-combinations of 4 different FRP face-sheet materials (phenolic woven glass fiber; epoxy woven glass fiber; epoxy woven carbon fiber; and hybrid layers) were investigated using the Digimat-HC modeling program in order to find the appropriate face-sheet construction. Face-sheets were built up in 1, 2, 4, 6 or 8 layers with sets of fiber orientations including cross-ply (0°, 90°) and/or angle-ply (±45°). The weight optimization method was elaborated considering 9 design constraints: stiffness, deflection, skin stress, core shear stress, facing stress, overall buckling, shear crimping, skin wrinkling, and intracell buckling. A case study for the base plate of an aircraft pallet was introduced to validate the optimization procedure carried out using the Matlab (Interior Point Algorithm) and Excel Solver (Generalized Reduced Gradient Nonlinear Algorithm) programs. In the case study, the weight of the optimal structure (epoxy woven carbon fiber face-sheets) was 27 kg, which provides weight savings of 66% compared to the standard aluminum pallet. The article’s main added value is the elaboration and implementation of an optimization method that results in significant weight savings and thus lower fuel consumption of aircraft.
Hybrid Filaments from Saccaharina lattisima Biomass: Engineering of Alginate Properties with Maleic Anhydride Grafted Linseed Oil
Authors: Sterner Martin , Edlund Ulrica
Published: March 2021

Linseed oil was graft modified with maleic anhydride and introduced into alginate by co-extrusion, producing alginate hybrid filaments. A straightforward grafting of maleic anhydride onto the oil backbone produced the modified oil. Additional esterification with n-dodecanol was also investigated. The structures of the modified oils were verified with 2D-NMR. The modified oil was mixed with alginate and extruded into CaCl2, forming thin filaments with diameters in the 130–260 μm range. The impact of oil integration into the alginate filaments was assessed, with special emphasis on stress-at-break, and compared to values predicted by an empirical model relating the “stress to alginate concentration” ratio to prevailing conditions during filament drawing. Analogous alginate filaments were prepared with hydrochloric-, oxalic- and phytic acid calcium salts for comparison with alginate–oil hybrids to reveal the induced impact, with respect to the composition and charge, on the tensile performance.
Influence of the Prepolymer Type and Synthesis Parameters on Self-Healing Anticorrosion Properties of Composite Coatings Containing Isophorone Diisocyanate-Loaded Polyurethane Microcapsules
Authors: Šobak Matic , Štular Danaja , Štirn Žiga , Žitko Gregor , Čelan Korošin Nataša , Jerman Ivan
Published: March 2021

Self-healing anticorrosion composite coatings containing isophorone diisocyanate-loaded polyurethane microcapsules were developed, and comprehensive research on prepolymer and microcapsules synthesis, as well as functional composite coatings preparation and characterization, was performed. The influence of the prepolymer type and the concentration of the stabilizing agent used in the synthesis procedure on the properties of the microcapsules was studied in detail. For this purpose, three different prepolymers were prepared from toluene-2,4-diisocyanate (TDI) and either glycerol, 1,4-butanediol, or 1,6-hexanediol, and their chemical properties were investigated. Microcapsules were synthesized from the obtained prepolymers, according to the oil-in-water polymerization method, where 1,6-hexanediol was used as a chain extender, while the concentration of the stabilizing agent in the synthesis procedure was varied. Microcapsules prepared from TDI-glycerol prepolymer, synthesized in the presence of 10 wt% of the stabilizing agent, showed superior chemical, morphological, and thermo-gravimetrical properties; thus, they were incorporated into the coating in the concentration of 20 wt%. The prepared composite coatings demonstrated self-healing and anticorrosion properties, and thus the developed microcapsules show great potential for the incorporation into the composite anticorrosion coatings at critical points where damage can easily occur, providing longer and more efficient anticorrosion protection.
Effect of Iodine Filler on Photoisomerization Kinetics of Photo-Switchable Thin Films Based on PEO-BDK-MR
Authors: Al-Bataineh Qais M. , Ahmad A. A. , Alsaad A. M. , Qattan I. A. , Aljarrah Ihsan A. , Telfah Ahmad D.
Published: March 2021

We report the effect of an iodine filler on photoisomerization kinetics of photo-switchable PEO-BDK-MR thin films. The kinetics of photoisomerization and time progression of PEO-BDK-MR/I2 nanocomposite thin films are investigated using UV-Vis, FTIR spectroscopies, and modified mathematical models developed using new analytical methods. Incorporating iodine filler into the PEO-BDK-MR polymeric matrix enhances the isomerization energy barrier and considerably increases the processing time. Our outcomes propose that enhanced photoisomerized and time processed (PEO-BDK-MR)/I2 thin films could be potential candidates for a variety of applications involving molecular solar thermal energy storage media.
Enriching Social Entrepreneurship from the Perspective of Catholic Social Teaching
Authors: McVea John F. , Naughton Michael J.
Published: March 2021

In this paper, we propose that unreflective use of the term social entrepreneurship may perpetuate the idea that “entrepreneurship” is largely a financial and private reality and that this view of entrepreneurship will eventually trivialize or perhaps undermine the important benefits and the real intentions behind the social entrepreneurship movement. We believe that Catholic Social Teaching can shed important light on this dilemma by emphasizing three specific strategies inherent to entrepreneurship when assessing the moral contribution of the firm. As a result, we argue for the principles of good goods, good work and good wealth as an alternative framework for all good entrepreneurial venture.
Reply to Comment on “Comparison of Cloud Cover Detection Algorithms on Sentinel–2 Images of the Amazon Tropical Forest”
Authors: Sanchez Alber Hamersson , Picoli Michelle Cristina A. , Camara Gilberto , Andrade Pedro R. , Chaves Michel Eustaquio D. , Lechler Sarah , Soares Anderson R. , Marujo Rennan F. B. , Simões Rolf Ezequiel O. , Ferreira Karine R. , Queiroz Gilberto R.
Published: March 2021

In their comments about our paper, the authors remark on two issues regarding our results relating to the MACCS-ATCOR Joint Algorithm (MAJA). The first relates to the sub-optimal performance of this algorithm under the conditions of our tests, while the second corresponds to an error in our interpretation of MAJA’s bit mask. To answer the first issue, we acknowledge MAJA’s capacity to improve its performance as the number of images increases with time. However, in our paper, we used the images we had available at the time we wrote our paper. Regarding the second issue, we misread the MAJA’s bit mask and mistakenly labelled shadows as clouds. We regret our error and here we present the updated tables and images. We corrected our estimation and, consequently, there is an increment in MAJA’s accuracy in the detection of clouds and cloud shadows. However, these increments are not enough to change the conclusion of our original paper.
Sentinel-1 Polarimetry to Map Apple Orchard Damage after a Storm
Authors: De Petris Samuele , Sarvia Filippo , Gullino Michele , Tarantino Eufemia , Borgogno-Mondino Enrico
Published: March 2021

Climate change increases extreme whether events such as floods, hailstorms, or storms, which can affect agriculture, causing damages and economic loss within the agro-food sector. Optical remote sensing data have been successfully used in damage detections. Cloud conditions limit their potential, especially while monitoring floods or storms that are usually related to cloudy situations. Conversely, data from the Polarimetric Synthetic Aperture Radar (PolSAR) are operational in all-weather conditions and are sensitive to the geometrical properties of crops. Apple orchards play a key role in the Italian agriculture sector, presenting a cultivation system that is very sensitive to high-wind events. In this work, the H-α-A polarimetric decomposition technique was adopted to map damaged apple orchards with reference to a stormy event that had occurred in the study area (NW Italy) on 12 August 2020. The results showed that damaged orchards have higher H (entropy) and α (alpha angle) values compared with undamaged ones taken as reference (Mann–Whitney one-tailed test U = 14,514, p < 0.001; U = 16604, p < 0.001 for H and α, respectively). By contrast, A (anisotropy) values were significantly lower for damaged orchards (Mann–Whitney one-tailed test U = 8616, p < 0.001). Based on this evidence, the authors generated a map of potentially storm-damaged orchards, assigning a probability value to each of them. This map is intended to support local funding restoration policies by insurance companies and local administrations.
Towards a Topographically-Accurate Reflection Point Prediction Algorithm for Operational Spaceborne GNSS Reflectometry—Development and Verification
Authors: King Lucinda , Unwin Martin , Rawlinson Jonathan , Guida Raffaella , Underwood Craig
Published: March 2021

GNSS Reflectometry (GNSS-R), a method of remote sensing using the reflections from satellite navigation systems, was initially envisaged for ocean wind speed sensing. In recent times there has been significant interest in the use of GNSS-R for sensing land parameters such as soil moisture, which has been identified as an Essential Climate Variable (ECV). Monitoring objectives for ECVs set by the Global Climate Observing System (GCOS) organisation include a reduction in data gaps from spaceborne sources. GNSS-R can be implemented on small, relatively cheap platforms and can enable the launch of constellations, thus reducing such data gaps in these important datasets. However in order to realise operational land sensing with GNSS-R, adaptations are required to existing instrumentation. Spaceborne GNSS-R requires the reflection points to be predicted in advance, and for land sensing this means the effect of topography must be considered. This paper presents an algorithm for on-board prediction of reflection points over the land, allowing generation of DDMs on-board as well as compression and calibration. The algorithm is tested using real satellite data from TechDemoSat-1 in a software receiver with on-board constraints being considered. Three different resolutions of Digital Elevation Model are compared. The algorithm is shown to perform better against the operational requirements of sensing land parameters than existing methods and is ready to proceed to flight testing.
Advanced Network Sampling with Heterogeneous Multiple Chains
Authors: Lee Jaekoo , Yoon MyungKeun , Noh Song
Published: March 2021

Recently, researchers have paid attention to many types of huge networks such as the Internet of Things, sensor networks, social networks, and traffic networks because of their untapped potential for theoretical and practical outcomes. A major obstacle in studying large-scale networks is that their size tends to increase exponentially. In addition, access to large network databases is limited for security or physical connection reasons. In this paper, we propose a novel sampling method that works effectively for large-scale networks. The proposed approach makes multiple heterogeneous Markov chains by adjusting random-walk traits on the given network to explore the target space efficiently. This approach provides better unbiased sampling results with reduced asymptotic variance within reasonable execution time than previous random-walk-based sampling approaches. We perform various experiments on large networks databases obtained from synthesis to real–world applications. The results demonstrate that the proposed method outperforms existing network sampling methods.
Automatic Ankle Angle Detection by Integrated RGB and Depth Camera System
Authors: Díaz-San Martín Guillermo , Reyes-González Luis , Sainz-Ruiz Sergio , Rodríguez-Cobo Luis , López-Higuera José M.
Published: March 2021

Depth cameras are developing widely. One of their main virtues is that, based on their data and by applying machine learning algorithms and techniques, it is possible to perform body tracking and make an accurate three-dimensional representation of body movement. Specifically, this paper will use the Kinect v2 device, which incorporates a random forest algorithm for 25 joints detection in the human body. However, although Kinect v2 is a powerful tool, there are circumstances in which the device’s design does not allow the extraction of such data or the accuracy of the data is low, as is usually the case with foot position. We propose a method of acquiring this data in circumstances where the Kinect v2 device does not recognize the body when only the lower limbs are visible, improving the ankle angle’s precision employing projection lines. Using a region-based convolutional neural network (Mask RCNN) for body recognition, raw data extraction for automatic ankle angle measurement has been achieved. All angles have been evaluated by inertial measurement units (IMUs) as gold standard. For the six tests carried out at different fixed distances between 0.5 and 4 m to the Kinect, we have obtained (mean ± SD) a Pearson’s coefficient, r = 0.89 ± 0.04, a Spearman’s coefficient, ρ = 0.83 ± 0.09, a root mean square error, RMSE = 10.7 ± 2.6 deg and a mean absolute error, MAE = 7.5 ± 1.8 deg. For the walking test, or variable distance test, we have obtained a Pearson’s coefficient, r = 0.74, a Spearman’s coefficient, ρ = 0.72, an RMSE = 6.4 deg and an MAE = 4.7 deg.
Design and Performance Evaluation of a “Fixed-Point” Spar Buoy Equipped with a Piezoelectric Energy Harvesting Unit for Floating Near-Shore Applications
Authors: Alizzio Damiano , Bonfanti Marco , Donato Nicola , Faraci Carla , Grasso Giovanni Maria , Lo Savio Fabio , Montanini Roberto , Quattrocchi Antonino
Published: March 2021

In the present work, a spar-buoy scaled model was designed and built through a “Lab-on-Sea” unit, equipped with an energy harvesting system. Such a system is based on deformable bands, which are loyal to the unit, to convert wave motion energy into electricity by means of piezo patch transducers. In a preliminary stage, the scaled model, suitable for tests in a controlled ripples-type wave motion channel, was tested in order to verify the “fixed-point” assumption in pitch and roll motions and, consequently, to optimize energy harvesting. A special type of structure was designed, numerically simulated, and experimentally verified. The proposed solution represents an advantageous compromise between the lightness of the used materials and the amount of recoverable energy. The energy, which was obtained from the piezo patch transducers during the simulations in the laboratory, was found to be enough to self-sustain the feasible on-board sensors and the remote data transmission system.
Modular MA-XRF Scanner Development in the Multi-Analytical Characterisation of a 17th Century Azulejo from Portugal
Authors: Lins Sergio Augusto Barcellos , Manso Marta , Lins Pedro Augusto Barcellos , Brunetti Antonio , Sodo Armida , Gigante Giovanni Ettore , Fabbri Andrea , Branchini Paolo , Tortora Luca , Ridolfi Stefano
Published: March 2021

A modular X-ray scanning system was developed, to fill in the gap between portable instruments (with a limited analytical area) and mobile instruments (with large analytical areas, and sometimes bulky and difficult to transport). The scanner has been compared to a commercial tabletop instrument, by analysing a Portuguese tile (azulejo) from the 17th century. Complementary techniques were used to achieve a throughout characterisation of the sample in a complete non-destructive approach. The complexity of the acquired X-ray fluorescence (XRF) spectra, due to inherent sample stratigraphy, has been resolved using Monte Carlo simulations, and Raman spectroscopy, as the most suitable technique to complement the analysis of azulejos colours, yielding satisfactory results. The colouring agents were identified as cobalt blue and a Zn-modified Naples-yellow. The stratigraphy of the area under study was partially modelled with Monte Carlo simulations. The scanners performance has been compared by evaluating the images outputs and the global spectrum.
Visualizing and Evaluating Finger Movement Using Combined Acceleration and Contact-Force Sensors: A Proof-of-Concept Study
Authors: Oigawa Hitomi , Musha Yoshiro , Ishimine Youhei , Kinjo Sumito , Takesue Yuya , Negoro Hideyuki , Umeda Tomohiro
Published: March 2021

The 10-s grip and release is a method to evaluate hand dexterity. Current evaluations only visually determine the presence or absence of a disability, but experienced physicians may also make other diagnoses. In this study, we investigated a method for evaluating hand movement function by acquiring and analyzing fingertip data during a 10-s grip and release using a wearable sensor that can measure triaxial acceleration and strain. The subjects were two healthy females. The analysis was performed on the x-, y-, and z-axis data, and absolute acceleration and contact force of all fingertips. We calculated the variability of the data, the number of grip and release, the frequency response, and each finger’s correlation. Experiments with some grip-and-release patterns have resulted in different characteristics for each. It was suggested that this could be expressed in radar charts to intuitively know the state of grip and release. Contact-force data of each finger were found to be useful for understanding the characteristics of grip and release and improving the accuracy of calculating the number of times to grip and release. Frequency analysis suggests that knowing the periodicity of grip and release can detect unnatural grip and release and tremor states. The correlations between the fingers allow us to consider the finger’s grip-and-release characteristics, considering the hand’s anatomy. By taking these factors into account, it is thought that the 10-s grip-and-release test could give us a new value by objectively assessing the motor functions of the hands other than the number of times of grip and release.
Deep Learning Driven Noise Reduction for Reduced Flux Computed Tomography
Authors: Alsamadony Khalid L. , Yildirim Ertugrul U. , Glatz Guenther , Waheed Umair Bin , Hanafy Sherif M.
Published: March 2021

Deep neural networks have received considerable attention in clinical imaging, particularly with respect to the reduction of radiation risk. Lowering the radiation dose by reducing the photon flux inevitably results in the degradation of the scanned image quality. Thus, researchers have sought to exploit deep convolutional neural networks (DCNNs) to map low-quality, low-dose images to higher-dose, higher-quality images, thereby minimizing the associated radiation hazard. Conversely, computed tomography (CT) measurements of geomaterials are not limited by the radiation dose. In contrast to the human body, however, geomaterials may be comprised of high-density constituents causing increased attenuation of the X-rays. Consequently, higher-dose images are required to obtain an acceptable scan quality. The problem of prolonged acquisition times is particularly severe for micro-CT based scanning technologies. Depending on the sample size and exposure time settings, a single scan may require several hours to complete. This is of particular concern if phenomena with an exponential temperature dependency are to be elucidated. A process may happen too fast to be adequately captured by CT scanning. To address the aforementioned issues, we apply DCNNs to improve the quality of rock CT images and reduce exposure times by more than 60%, simultaneously. We highlight current results based on micro-CT derived datasets and apply transfer learning to improve DCNN results without increasing training time. The approach is applicable to any computed tomography technology. Furthermore, we contrast the performance of the DCNN trained by minimizing different loss functions such as mean squared error and structural similarity index.
Critical Reflection: An Imperative Skill for Social Work Practice in Neoliberal Organisations?
Authors: Morley Christine , O’Bree Charlie
Published: March 2021

Social work practice and education have been significantly impacted by neoliberal governmentality, which can greatly undermine the espoused social justice mission of social work. This study explores the research questions: How might critical reflection support social work practice in neoliberal organisations? And how might critical analysis using insights from critical theorists fortify the findings of critically reflective research? This study uses critical reflection on a critical incident (from Author 2’s practice) as a methodology to respond to the first research question. It further analyses the findings of the critically reflective inquiry by drawing on relevant concepts from critical theorists to respond to the second question and expand the possibilities for practitioners to develop emancipatory practices in neoliberal organisations. The findings suggest critical reflection on the critical incident examined was effective in improving social work practice, and that additional critical analysis of the wider issues raised by the research findings may enhance social work as a value-driven, client-centred and social change-oriented profession. The article highlights the benefits and outcomes of working in a critically reflective way, and makes an original contribution to the growing literature that suggests critical reflection is a vital skill for social work practice in neoliberal organisations.