bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Chicken Bile Application on Scar Healing Process
Authors: Limanda Claudia Felicia , Intizam Marwa Humaira , Jusuf Pierre Joshua , Tanujaya Monica Aprilia , Rusyati Luh Made Mas
Published: March 2024

Type of scars varies from mild fine line scars to abnormal scars which treatment will differ according to its type, site, symptoms, and severity. Scars have a great impact of human life, namely physically, aesthetically, psychologically, and socially that make choosing the right treatment very important. Treatment for scars can be done conventionally in health care facilities and traditionally. Chinese traditional medicine has been known to have a major role in scar treatment. One of the examples is the use of chicken bile. "Chicken bile", "Chicken bile effect", "Wounds", and "Wound healing process" were the keywords applied to scientific online databases. Wound healing is composed of three initial stages, such as inflammatory, proliferative, and remodeling stage. Chicken bile is known to have a low but strong bilirubin level with little biliverdin. These agents can serve as antipyretic, antioxidant, anti-inflammatory, and anti-atherogenic that can aide wound healing. Bile also supports protein metabolism, fat metabolism, energy production, and synthesis of glycogen. Most importantly, bile contains matrix metalloproteinases (MMPs) that function to degrade type IV collagen which have an important role in wound reepithelization process, altering wound matrix, enabling cell to migrate, and tissue remodeling. Thus, it is certain that MMPs are essential in wound healing.
Markedly clinical improvement of papulopustular rosacea with multimodality therapeutic approach: a case report
Authors: Priyanto Mufqi Handaru , Wardani Amanda Nandi , Legiawati Lili , Sitohang Irma Bernadette Simbolon , Suseno Lis Surachmiati
Published: March 2024

Introduction: Rosacea is a chronic inflammatory skin disease that mainly affects the central area of the face. There are four subtypes, and they may progress between subtypes or span multiple subtypes. Due to its long course of the disease, optimum treatments are needed to control the disease progression.
Case: We reported rapid improvement of combining topical metronidazole, doxycycline, and light emitting diode for treating a patient with papulopustular rosacea in a 44-years-old woman, a week from the initial therapy.
Discussion: Therapeutic approaches to rosacea mainly focus on controlling the symptoms with anti-inflammatory agents. More recently, photodynamic therapy, especially light-emitting diodes, has been introduced as a valid alternative or an adjuvant therapy to conventional treatment through their synergic mechanism between therapeutic modalities.
Conclusions: This combination treatment may be effective for treating papulopustular rosacea without any side effects.
Clinical features of allergic contact dermatitis to sandals: a case series
Authors: Gotama Sinta , Hapsari Yunita , Kusuma Dinie Ramdhani
Published: March 2024

Background: Allergic contact dermatitis (ACD) is a skin inflammation caused by a type 4 delayed-type hypersensitivity reaction. One of the most common types of ACD is shoe dermatitis, characterized by pruritic or painful bilateral and symmetrical erythema, papules, vesicles, scaling, crusting, lichenification, or fissures at the site of footwear contact.
Case series: We present seven patients with allergic contact dermatitis caused by rubber flip-flop sandals who presented with acute to chronic eczema and leukoderma. Patients range in age from 4 to 65 years old, with symptoms lasting from 5 months to 2 years. Two of the seven patients had a history of atopy.
Conclusion: Flip-flop sandals are the most common offending footwear in Indonesian ACD patients because they are appropriate and comfortable in hot and humid climates like Indonesia. Rubber and rubber chemicals, preservatives, shoe adhesives, and leather materials are the most common offending allergens.
Adjuvant therapies of acne: review of literatures
Authors: Randy Satria Nugraha Rusdy  , Lili Legiawati  , Irma Bernadette Simbolon Sitohang  , Sondang Marisi Holong Aemilia Pandjaitan Sirait
Published: March 2024

Acne is a chronic inflammatory disorder affecting pilosebaceous unit with various clinical manifestation from comedone, papule, pustule, to nodule and cyst. Choice of treatment is based on acne severity. Prolong antibiotic use along with restriction of isotretinoin use in Indonesia can be a challenge in managing acne. A lot of treatment options from topical agent, systemic medication, comedone extraction, intralesional corticosteroid injection, chemical peeling, light and laser-based therapy, as well as diet modification can be used as an adjuvant to improve acne. Review of literatures was performed to present recent evidence toward the effectivity of adjuvant therapy as a part of acne management.
Profile of pyoderma in dermatology outpatient departement at Sanglah General Hospital Denpasar, Bali-Indonesia period January 2016 until December 2017
Authors: Ni Luh Putu Ratih Vibriyanti Karna  , Dewi Gotama  , Sissy
Published: March 2024

Introduction: Pyodermas are infections in the epidermis, just below the stratum corneum or in hair follicles. It is most common in children, although it can also affect adults. Pyoderma often found in tropic areas. Pyoderma is caused by Staphylococcus, Streptococcus, or both. This study aimed to identify the profile of pyoderma in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.

Method: Study design using descriptive retrospective model, done by taking data from daily visit record in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.

Result: Pyodermas is one of the common skin problems observed in patients attending dermatology OPD. The number of new cases in pyoderma is 202 cases (7,32%), often found in males and 0-5 years age group (35,64%). The diagnosis of furuncle is the most finding type of pyoderma and the most commonly given therapy is a combination therapy of systemic antibiotics with topical. Co-amoxiclav is the most common drug that uses orally and fusidic acid as topical ointment.

Conclusion: pyoderma remains as the most common skin infection in dermatology outpatient department at Sanglah General Hospital, Bali-Indonesia.

Introduction: Pyodermas are infections in the epidermis, just below the stratum corneum or in hair follicles. It is most common in children, although it can also affect adults. Pyoderma often found in tropic areas. Pyoderma is caused by Staphylococcus, Streptococcus, or both. This study aimed to identify the profile of pyoderma in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.

Method: Study design using descriptive retrospective model, done by taking data from daily visit record in Dermatology Outpatient Department at Sanglah General Hospital Denpasar Periods January 2016 – December 2017.

Result: Pyodermas is one of the common skin problems observed in patients attending dermatology OPD. The number of new cases in pyoderma is 202 cases (7,32%), often found in males and 0-5 years age group (35,64%). The diagnosis of furuncle is the most finding type of pyoderma and the most commonly given therapy is a combination therapy of systemic antibiotics with topical. Co-amoxiclav is the most common drug that uses orally and fusidic acid as topical ointment.

Conclusion: pyoderma remains as the most common skin infection in dermatology outpatient department at Sanglah General Hospital, Bali-Indonesia.
The effectiveness of galactomyces ferment filtrate, dexpanthenol, and Centella asiatica combination serum in the treatment of post-acne hyperpigmentation
Authors: We Sagara Dewi  , Ivan Kurniadi  , Anis Irawan Anwar
Published: March 2024

Background: Acne vulgaris is a chronic inflammation of the pilosebaceous gland that may result in non-inflammatory and inflammatory lesions. A hypermelanotic reaction to skin inflammation causes post-acne hyperpigmentation (PAH). It can occur secondary to the inflammation process and, depending on the severity, may persist for a prolonged period.

Objective To determine the effectiveness of galactomyces ferment filtrate (GFF), dexpanthenol, and Centella asiatica combination serum in the treatment of PAH

Methods: This was a placebo-controlled randomized clinical trial. Sixty-eight subjects were divided into two groups: the experimental group received combination serum while the control group received a placebo for eight weeks. Three drops of serum were applied to the area with PAH twice daily in the morning and night. The melanin, erythema, roughness, and L*, a*, and b* scores were assessed objectively using mexameter, chromameter and skin analyzer every two weeks. Pearson’s correlation test and independent T-test were used to assess the trend of the parameters and compare the results of both groups.

Results: The results of statistical calculations using the Pearson correlation test showed the treatment group showed a significant decreasing trend of the melanin and spots score. Both groups showed a significant decreasing trend in erythema, L* score and roughness. However, no significant difference was found between both groups in all parameters.

Conclusion: The combination serum may decrease the melanin and spot scores suggesting that it affects the melanocyte activity. It has shown good efficacy in treating PAH.
Steven johnson syndrome induce by carbamazepine in epileptic patient: a case report
Authors: Nyoman Yoga Maya Pramita  , Prima Saraswati Sanjiwani Sudarsa  , Ratih Purnamasari Nukana
Published: March 2024

Introduction: Steven Johnson Syndrome (SJS) is life-threatening skin reaction, it is a mucocutaneous disorder induced by immune complex-mediated hypersensitivity reaction. Most frequent offending agents are antibiotic, antiretroviral and aromatic anticonvulsants. Problems arise when these drugs are required for long-term use and necessary for several health conditions. These case series aim to describe SJS and provide replacement therapy especially inpatient with epilepsy.

Case report: A 37 years old female was consulted from neurology department with chief complaints an erythematous rash on her chest, back upper and lower extremities accompanied with fever, the patient also complaint erosions on her lips. She had history of seizure and was prescribe Carbamazepine. Carbamazepine was replaced and patient treated with dexamethasone intravenously. After 1 week of admitted there is an improvement.

Conclusion: Steven Johnson Syndrome (SJS) is a life-threatening disease, the replacement of the suspected drugs and appropriate therapy can improve the prognosis of patient.
Incidence and characteristic of psoriasis patients at Sanjiwani Gianyar Regional Hospital 2018-2019
Authors: Annisa Alviariza  , Sayu Widyawati
Published: March 2024

Introduction: Psoriasis is a chronic inflammatory skin disease characterized by firmly demarcated red plaque covered by a thick squama due to impaired proliferation and differentiation of the epidermis. Diagnosis of psoriasis is based on history taking and clinical features. Treatment is determined based on the patient's clinical characteristics and the severity of the disease. This retrospective study aims to determine the incidence, characteristics, and treatment options of psoriasis patients in the Dermatology and Venereology Polyclinic of Sanjiwani Gianyar Regional Hospital in 2018-2019.

Methods: A retrospective study of psoriasis patients at Sanjiwani Gianyar Regional Hospital in 2018-2019. Data collected from medical records includes sociodemographic data, clinical data, and patient treatment history.

Results: Within two years, there were 53 cases of psoriasis. The dominance of psoriasis cases was found in men with a ratio of women and men 1:2.31. Of total 53 patients, 37 were male (69.81%)and 16 female patients (30.19%). The most common type was psoriasis vulgaris (73.58%). The most age group was 31-45 years. The most commonly given regimen of therapy was topical corticosteroids plus oral antihistamines (45.28%). The most widely given systemic therapy was methotrexate. Accompanying skin infections were found in 6 cases of psoriasis (11.32%).

Conclusion: Based on the results of the study, there were 53 new cases of psoriasis in 2018-2019, psoriasis vulgaris was the most common, the most age group was 31-45 years old, topical corticosteroids with antihistamines were still the main treatment options for psoriasis patients in Sanjiwani Gianyar Regional Hospital.
Case report: a child with type 1 neurofibromatosis and intellectual disability
Authors: Elice Wijaya  , Ni Luh Putu Ratih Vibriyanti Karna  , Ida Ayu Uttari Priyadarshini
Published: March 2024

Background: Neurofibromatosis is a genetic disorder that manifests as a tumor surrounding the nerves and several other pathologic presentations.

Case: Female, 11 years old, according to history, physical examination and supporting the investigation, was consistent with the diagnostic criteria of type 1 neurofibromatosis (NF-1). The patient also has an intellectual disability. A tumor on the foot region that was functionally disabling was found on the patient, and surgical treatment was performed.  Cognitive disorder is the most common neurological complication in individuals with NF-1 and usually presents with a low intelligence quotient (IQ). There is no specific treatment to prevent the development of NF-1. However, early treatment can minimize and prevent further complications. Treatment for the patient involves multiple clinical disciplines.

Conclusion: A neurofibromatosis case can be diagnosed clinically alone, since many other systemic involvements require a multi-disciplinary approach.
Cyclooxygenase-2 as potential intervention target of leprosy reactions: a systematic review
Authors: Rusyati Luh Made Mas , Sari Luh Gede Melia Puspita , Winaya Ketut Kwartantaya
Published: March 2024

Background: Leprosy reaction is an acute inflammatory of leprosy complication that potentially cause disability. Prompt and appropriate treatment is needed to prevent this permanent neurological complication. As inflammation of this reaction is mediated by cyclooxygenase-2 (COX-2), therefore targeting this substance may potential to prevent disability. This systematic review aimed to define COX-2 as a potential target of intervention in leprosy reaction.
Method: Medline, Cochrane library, PubMed, and Google scholar databases were searched for articles published at any time. Observational study and clinical trial, comparative, prospective, retrospective, and descriptive study were extracted, analyzed, and discussed.
Results: We found 6 studies that met the inclusion and exclusion criteria, with 104 participants with leprosy reactions and 143 comparators included in this review. In leprosy reactions, COX-2 expression was found in the vessels and nerves of the dermis and subcutis. Macrophages are cell mostly abundantly expressing COX-2. The COX-2 expression was found higher in the leprosy reaction compare to the non-leprosy reaction. Genetically, genes PTGS2 and TNFAIP6 encode COX-2 production also tend to increase especially in type 1 reaction.
Conclusions: Preclinically and genetically, COX-2 is a potential target for intervention of leprosy reaction.
The high homeostatic model assessment of insulin resistance as risk factor for acne vulgaris
Authors: I Gusti Ayu Agung Praharsini  , Anak Agung Gde Putra Wiraguna  , Stefani Nurhadi
Published: March 2024

Background: Acne vulgaris (AV) is a common chronic skin disease involving blockage and or inflammation of pilosebaceous glands which usually affects teenagers and young adults. Elevated sebaceous gland secretion, Propionibacterium acne colonization and inflammation, high androgen effects, and follicular hyperproliferation are the main pathogenic factors of AV. IGF-1 and insulin were studied to stimulate sebaceous lipogenesis. In the skin, besides inducing lipid production in human sebocytes IGF-1 also induces keratinocyte proliferation in vitro and in vivo. HOMA-IR is an examination to determine insulin activity in the basal state.

Objective: To prove that high HOMA-IR value is a risk factor for the occurrence of acne vulgaris.

Methods: This study is a case control analytic study by comparing HOMA-IR in subjects with AV (case group) and non AV (control group). AV is diagnosed based on clinical predilection. Insulin testing was carried out by the immulite 2000 device through the immunochemiluminescent method.

Results: Mean HOMA-IR of case group is 2.63 ± 0.29 meanwhile in the control group was 1.71 ± 0.26 (p <0.001). Subjects with high HOMA-IR had 4.8 times higher risk to experience AV compared to patients with normal HOMA-IR values (p <0.001; 95% CI 2.765-8.332).

Conclusion: HOMA-IR values in acne patients were higher than controls. A high HOMA-IR value is an AV risk factor.
Application of Artificial Intelligence to Monitor Leaks from Pumps
Authors: Dankwa O. K. , Mensah J. S. , Amarfio E. M. , Amenyah Kove E. P.
Published: March 2024

During the production of hydrocarbons, offshore platforms frequently leak large volumes of oil and gas. Traditional methods for detecting these leaks are prone to errors, making them inefficient at detecting leaks precisely. These leaks, however, have damaging effects on the environment and humans, posing economic risks to companies as well. This study explores the application of artificial intelligence to monitor pump leaks. The data used in this work was obtained from Kaggle, which contained sensor readings from pumps. Supervised (random forest, support vector machine, and naïve bayes) and unsupervised (isolation forest) machine learning algorithms were employed for leak detection. The results showed that supervised machine learning algorithms were more accurate, with random forest having the greatest F1-score (0.993). Leveraging artificial intelligence for leak monitoring proved effective, offering a promising alternative to traditional methods.
ANÁLISE DA URGÊNCIA NA INCORPORAÇÃO DAS CATEGORIAS DE GÊNERO E RAÇA NO CURRÍCULO DA EDUCAÇÃO INFANTIL EM BAURU-SP
Authors: Alvares Deborah Miranda , Sousa André Cristovão , Soares Lucia Isabel Aparecida
Published: March 2024

Este estudo científico investiga os efeitos da inclusão de temas de gênero e raça no currículo da Educação Infantil em Bauru, São Paulo, visando compreender como essa incorporação influencia a organização do ensino e contribui para a formação cidadã dos estudantes. O objetivo principal é compreender como a inclusão desses temas afeta a estrutura do ensino e seu impacto na formação dos alunos, reconhecendo o currículo como um reflexo do projeto de sociedade. Utilizando uma abordagem qualitativa, com análise bibliográfica, o estudo busca proporcionar uma compreensão mais profunda da inserção das categorias de Gênero e Raça no currículo da Educação Infantil de Bauru, São Paulo. Além disso, baseia-se na contextualização teórica do Currículo, segundo os autores Sacristán (2013; 2017) e Schubert (1986). A análise do currículo existente e a identificação de lacunas na abordagem de gênero e raça destacam a necessidade de revisões curriculares sensíveis e inclusivas, com o intuito de promover a reflexão sobre diversidade, identidade e respeito desde a infância. Discute-se também os possíveis impactos dessa inclusão na redução de estereótipos e preconceitos, na promoção da igualdade e justiça social, e na formação de indivíduos conscientes e comprometidos com a construção de uma sociedade mais equitativa. As conclusões ressaltam a importância de uma escola engajada na promoção da diversidade e inclusão, além de apontar para direções futuras de pesquisa sobre o tema.
O CORPO DA MULHER COMO ALVO DE VIOLAÇÕES: UM ESTUDO SOBRE A VIOLÊNCIA OBSTÉTRICA
Authors: Cruz Maria Eduarda Carlos , Azevedo Thiago Augusto Galeão de
Published: March 2024

O presente artigo tem por objetivo geral analisar a invisibilidade do termo violência obstétrica na sociedade, sua prática como violação de gênero e sua utilização nas demandas judiciais. Como objetivos específicos, buscou-se conceituar o termo violência obstétrica e suas modalidades de ação, analisar a violência obstétrica como uma violação do corpo da mulher e entender sua execução como uma violência de gênero, dos direitos humanos e das mulheres e a postura da legislação brasileira. Para tanto, o método utilizado foi o expositivo, explicativo e bibliográfico, a partir da análise doutrinária, jurisprudencial, de leis, tratados internacionais, livros e documentos. Além de estudos de casos concretos por meio de banco de dados disponíveis.
CUIDADOS DE ENFERMAGEM AO DOENTE COM VENTILAÇÃO MECÂNICA INVASIVA NO SERVIÇO DE URGÊNCIA: UMA SCOPING REVIEW
Authors: Malacas Manuel Sabino , Martins Dânia Patrícia Meia Onça , Santiago Maria Dulce dos Santos
Published: March 2024

Introdução: Diversos estudos internacionais mostram-nos que cada vez mais se assiste a um crescente número de doentes críticos submetidos a ventilação mecânica invasiva (VMI) no serviço de urgência (SU) e nele permanecem por mais tempo. A sua permanência nestes serviços está ligada a piores resultados. Estes são doentes que exigem dos enfermeiros que deles cuidam conhecimentos e competências acerca dos melhores cuidados a serem prestados, pois estes vão ter influência no sucesso da sua recuperação.Objetivo: Mapear a evidência científica disponível acerca das boas práticas a adotar no cuidado ao doente crítico sob VMI em contexto de urgência hospitalar.  Método: Realizou-se uma scoping review de acordo com as indicações do Joanna Briggs Institute (JBI). A pesquisa foi realizada nas bases de dados MEDLINE, CINAHL, LILACS e BDENF – Enfermagem, com limitação temporal de artigos publicados entre os anos 2019 e 2023, respeitando critérios de inclusão e exclusão, resultando num total de cinco artigos.Resultados: A análise dos cinco estudos incluídos permitiu identificar vinte e quatro intervenções consideradas boas práticas para uma maior qualidade dos cuidados e segurança dos doentes submetidos a VMI que permaneçam no SU.Conclusão: Os resultados obtidos vieram demonstrar a importância destas intervenções para o sucesso da VMI, no entanto, existem discrepâncias na forma como os enfermeiros cuidam destes doentes, não havendo uniformização quanto à sua aplicabilidade. É necessário mais estudos, formação e elaboração de normas adaptadas ao contexto do SU.
Opinion: A paradigm shift in investigating the general characteristics of atmospheric new particle formation using field observations
Authors: Kulmala Markku , Aliaga Diego , Tuovinen Santeri , Cai Runlong , Junninen Heikki , Yan Chao , Bianchi Federico , Cheng Yafang , Ding Aijun , Worsnop Douglas R. , Petäjä Tuukka , Lehtipalo Katrianne , Paasonen Pauli , Kerminen Veli-Matti
Published: March 2024

Abstract. Atmospheric new particle formation (NPF) and associated production of secondary particulate matter dominate aerosol particle number concentrations and submicron particle mass loadings in many environments globally. Our recent investigations show that atmospheric NPF produces a significant amount of particles on days when no clear NPF event has been observed/identified. Furthermore, it has been observed in different environments all around the world that growth rates of nucleation mode particles vary little, usually much less than the measured concentrations of condensable vapors. It has also been observed that the local clustering, which in many cases acts as a starting point of regional new particle formation (NPF), can be described with the formation of intermediate ions at the smallest sizes. These observations, together with a recently developed ranking method, lead us to propose a paradigm shift in atmospheric NPF investigations. In this opinion paper, we will summarize the traditional approach of describing atmospheric NPF and describe an alternative method, covering both particle formation and initial growth. The opportunities and remaining challenges offered by the new approach are discussed.
Sedimentary protolith and high-P metamorphism of oxidized manganiferous quartzite from the Lanterman Range, northern Victoria Land, Antarctica
Authors: Kim Taehwan , Kim Yoonsup , Tumiati Simone , Kim Daeyeong , Yi Keewook , Lee Mi Jung
Published: March 2024

Abstract. We investigated the mineral assemblage, mineral and bulk-rock chemistry, and zircon U–Pb age of a manganiferous quartzite layer in the Lanterman Range, northern Victoria Land, Antarctica. The mineral assemblage consists primarily of phengite and quartz, along with spessartine-rich garnet, Mn3+ and rare earth element–yttrium (REY)-zoned epidote-group minerals, and titanohematite. Mineral inclusions such as tephroite, rutile and pyrophanite are hosted in porphyroblasts of the latter three minerals and suggest prograde blueschist-facies to low-T eclogite-facies metamorphism (M1). Epidote-group minerals commonly exhibit multiple growth zones of piemontite and/or epidote (M1), REY-rich piemontite (M2), REY-rich epidote (M3), and epidote (M4) from core to rim. Pseudobinary fO2–X diagrams at constant P–T support the stability of an epidote-group mineral-bearing assemblage under highly oxidized conditions during prograde M2 to peak M3 metamorphism. In marked contrast, tephroite-bearing assemblages (M1) are limited to relatively reduced environments and Mn-rich, silica-deficient bulk-rock compositions. Mn nodules have such characteristics, and the contribution of this hydrogenous component is inferred from bulk-rock chemical features such as a strong positive Ce anomaly. The major-element composition of the manganiferous quartzite suggests a protolith primarily consisting of a mixture of chert and pelagic clay. The presence of rare detrital zircons supports terrigenous input from a craton and constrains the maximum time of deposition to be ca. 546 Ma. The lack of arc-derived detrital zircons in the quartzite and the predominance of siliciclastic metasedimentary rocks among the surrounding rocks suggest that the deep-sea protolith was most likely deposited in an arc/back-arc setting at a continental margin. High-P metamorphism associated with terrane accretion during the Ross orogeny took place in the middle Cambrian (ca. 506 Ma), broadly coeval with the metamorphic peak recorded in the associated high-P rocks such as mafic eclogites. Finally, it is noteworthy that the high-P manganiferous quartzite was amenable to exhumation because the paleo-position of the protolith was likely distal from the leading edge of the downgoing slab.
Solar radiation modification challenges decarbonization with renewable solar energy
Authors: Baur Susanne , Sanderson Benjamin M. , Séférian Roland , Terray Laurent
Published: March 2024

Abstract. Solar radiation modification (SRM) is increasingly being discussed as a potential tool to reduce global and regional temperatures to buy time for conventional carbon mitigation measures to take effect. However, most simulations to date assume SRM to be an additive component to the climate change toolbox, without any physical coupling between mitigation and SRM. In this study we analyze one aspect of this coupling: how renewable energy (RE) capacity, and therefore decarbonization rates, may be affected under SRM deployment by modification of photovoltaic (PV) and concentrated solar power (CSP) production potential. Simulated 1 h output from the Earth system model CNRM-ESM2-1 for scenario-based experiments is used for the assessment. The SRM scenario uses stratospheric aerosol injections (SAIs) to approximately lower global mean temperature from the high-emission scenario SSP585 baseline to the moderate-emission scenario SSP245. We find that by the end of the century, most regions experience an increased number of low PV and CSP energy weeks per year under SAI compared to SSP245. Compared to SSP585, while the increase in low energy weeks under SAI is still dominant on a global scale, certain areas may benefit from SAI and see fewer low PV or CSP energy weeks. A substantial part of the decrease in potential with SAI compared to the SSP scenarios is compensated for by optically thinner upper-tropospheric clouds under SAI, which allow more radiation to penetrate towards the surface. The largest relative reductions in PV potential are seen in the Northern and Southern Hemisphere midlatitudes. Our study suggests that using SAI to reduce high-end global warming to moderate global warming could pose increased challenges for meeting energy demand with solar renewable resources.
Sea-ice variations and trends during the Common Era in the Atlantic sector of the Arctic Ocean
Authors: Dauner Ana Lúcia Lindroth , Schenk Frederik , Power Katherine Elizabeth , Heikkilä Maija
Published: March 2024

Abstract. Sea ice is crucial in regulating the heat balance between the ocean and atmosphere and quintessential for supporting the prevailing Arctic food web. Due to limited and often local data availability back in time, the sensitivity of sea-ice proxies to long-term climate changes is not well constrained, which renders any comparison with palaeoclimate model simulations difficult. Here we compiled a set of marine sea-ice proxy records with a relatively high temporal resolution of at least 100 years, covering the Common Era (past 2k years) in the Greenland–North Atlantic sector of the Arctic to explore the presence of coherent long-term trends and common low-frequency variability, and we compared those data with transient climate model simulations. We used cluster analysis and empirical orthogonal functions to extract leading modes of sea-ice variability, which efficiently filtered out local variations and improved comparison between proxy records and model simulations. We find that a compilation of multiple proxy-based sea-ice reconstructions accurately reflects general long-term changes in sea-ice history, consistent with simulations from two transient climate models. Although sea-ice proxies have varying mechanistic relationships to sea-ice cover, typically differing in habitat or seasonal representation, the long-term trend recorded by proxy-based reconstructions showed a good agreement with summer minimum sea-ice area from the model simulations. The short-term variability was not as coherent between proxy-based reconstructions and model simulations. The leading mode of simulated sea ice associated with the multidecadal to centennial timescale presented a relatively low explained variance and might be explained by changes in solar radiation and/or inflow of warm Atlantic waters to the Arctic Ocean. Short variations in proxy-based reconstructions, however, are mainly associated with local factors and the ecological nature of the proxies. Therefore, a regional or large-scale view of sea-ice trends necessitates multiple spatially spread sea-ice proxy-based reconstructions, avoiding confusion between long-term regional trends and short-term local variability. Local-scale sea-ice studies, in turn, benefit from reconstructions from well-understood individual research sites.
The upstream–downstream connection of North Atlantic and Mediterranean cyclones in semi-idealized simulations
Authors: Scherrmann Alexander , Wernli Heini , Flaounas Emmanouil
Published: March 2024

Abstract. Cyclogenesis in the Mediterranean is typically triggered by the intrusion of a potential vorticity (PV) streamer over the Mediterranean. The intrusion of the PV streamer results from a preceding Rossby wave breaking (RWB) upstream over the North Atlantic. The ridge leading to the RWB is typically amplified by the presence of warm conveyor belts (WCBs) in at least one North Atlantic cyclone about 4 d prior to Mediterranean cyclogenesis. Thus, the sequence of these four main events (namely a North Atlantic cyclone, WCBs, RWB, and the resulting PV streamers) forms an archetypal scenario leading to Mediterranean cyclogenesis. However, they rarely occur in a spatially consistent, fully repetitive pattern for real cyclone cases. To more systematically study this connection between upstream North Atlantic cyclones and Mediterranean cyclogenesis, we perform a set of semi-idealized simulations over the Euro-Atlantic domain. For these simulations, we prescribe a constant climatological atmospheric state in the initial and boundary conditions. To trigger the downstream Mediterranean cyclogenesis scenario, we perturb the climatological polar jet through the inversion of a positive upper-level PV anomaly. The amplitude of this perturbation determines the intensity of the triggered North Atlantic cyclone. This cyclone provokes RWB, the intrusion of a PV streamer over the Mediterranean, and thereby the formation of a Mediterranean cyclone. Therefore, our results show a direct connection between the presence of a North Atlantic cyclone and the downstream intrusion of a PV streamer into the Mediterranean, which causes cyclogenesis about 4 d after perturbing the polar jet. We refer to this as the upstream–downstream connection of North Atlantic and Mediterranean cyclones. To investigate the sensitivity of this connection, we vary the position and amplitude of the upper-level PV anomaly. In all simulations, cyclogenesis occurs in the Mediterranean. Nevertheless, the tracks and intensity of the Mediterranean cyclones may vary by up to 20° and 10 hPa (at the time of the mature stage), respectively. This indicates that the Mediterranean cyclone dynamics are sensitive to the dynamical structure and amplitude of the intruding PV streamer, which itself is sensitive to the interaction of the upstream cyclone and the RW(B). By applying different seasonal climatological atmospheric states as initial conditions we show that cyclogenesis occurs in distinct regions in different seasons. Thus, the seasonal cycle of Mediterranean cyclogenesis might be partly determined by the large-scale atmospheric circulation, i.e., the seasonal location of the polar jet. Furthermore, we show that the Mediterranean cyclones in these semi-idealized simulations show characteristics that agree with the observed climatology of Mediterranean cyclones in the respective season.
First Record of Leucopholis lepidophora Blanchard, 1850 (Scarabaeidae; Melolonthinae) from Western Himalayas along with a Checklist of the Genus Leucopholis from India
Authors: Kumar Mayank , Pandey Ajay Kumar
Published: March 2024

Melolonthinae is a subfamily of June beetles and contains many species of agronomic importance in India. It holds major genera like Brahmina (Blanchard 1850), Eotrichia (Medvedev 1951), Holotrichia (Hope 1837) and Sophrops (Fairmaire 1887) in India. A survey based on light trap collection was conducted in the terai foot hills of the Western Himalaya in Uttarakhand to check for the presence of the species. During surveys in the years 2021-22 and 2022-23, various chafer beetles were collected to observe the distribution pattern and their hosts. Among these various species, one beetle species is here reported for the first time i.e., Leucopholis lepidophora Blanchard, 1850, from Uttarakhand, India. This also represents their first record for Western Himalaya. Their habitus and male genitalia are provided herein to aid in identification. A preliminary checklist of Indian Leucopholis is also provided.
Pudendal Nerve Neurolysis in Patients Afflicted With Pudendal Nerve Entrapment: A Systematic Review of Surgical Techniques and Their Efficacy
Authors: Giulioni Carlo , Pirola Giacomo Maria , Maggi Martina , Pitoni Lucia , Fuligni Demetra , Beltrami Mattia , Palantrani Vanessa , De Stefano Virgilio , Maurizi Valentina , Castellani Daniele , Galosi Andrea Benedetto
Published: March 2024

To assess the effectiveness and safety of various techniques of pudendal nerve neurolysis (PNN) in patients with pudendal nerve entrapment (PNE). A comprehensive literature search was conducted on May 20th, 2023, using Scopus, PubMed, and Embase databases. Only studies in English involving adults were accepted, while meeting abstracts and preclinical studies were excluded. A total of 34 papers were included. Transperineal PNN emerged as a promising technique, demonstrating significant potential in alleviating pain, restoring erectile function in males, and improving the resolution of urinary stress incontinence in females. Furthermore, the bilateral approach consistently yielded positive outcomes in addressing urinary symptoms. The transgluteal technique appeared particularly suitable for cases of posterior PNE, situated between the sacrospinous ligament and the lesser sciatic foramen. A progressive amelioration of painful symptoms was observed during follow-up. Minimally invasive PNN is evolving and enables decompression along the entire proximal tract up to the Alcock canal, minimizing the risk of comorbidities. In addition to reducing pudendal neuralgia, robot-assisted and laparoscopic approaches determined a reduction in lower urinary tract symptoms and an improvement in erectile function, though further studies are required to corroborate these findings. PNN emerges as an effective treatment for PNE with minimal morbidity. Therefore, PNN should be tailored according to the site of PNE to enhance functional outcomes and improve patient quality of life.
Evaluation of interleukin-23 expression in classic kaposi’s sarcoma and AIDS-Associated
Authors: Jamersson Arlindo Miranda Francisco , Neves Miranda Lidyane , Priscila Santos Reginaldo Fernanda , Da Paz Mangabeira Cleverton , Cristiana de Oliveira Crispim Janaína , Pignataro Lima Francisco , Juvenal Silva Farias Kleber , Lima Machado Paula Renata
Published: March 2024

Kaposi’s sarcoma (KS) is a low-grade vascular tumor that presents most frequently with skin lesions. Multiple factors are related to KS pathogenesis. The interleukin-23 (IL-23) is an immunomodulatory cytokine with pro-carcinogenic role. The aim of this study was to evaluate the detection of IL-23 in cutaneous lesions of patients with KS classic and KS-AIDS. This was a cross-sectional study conducted at the public Hospital in Natal, Rio Grande do Norte, Brazil. This study included 13 biopsies of patients which presented KS with histopathological confirmation. For detection of IL-23, the immunohistochemical analysis was made with monoclonal antibody anti-IL-23. The immunostaining for IL-23 in biopsies was positive in 61.5% (8/13) of cases. Of seven lesions classified as patch-stage, three were positive for IL-23 (42.8%); two of three samples classified as plaque-stage were positive for IL-23 (66.7%); all the nodular-stage lesions were positive for IL-23. The positivity found in KS-AIDS lesions was 66.7% (6/9) and KS classic 50% (2/4). Our data supports the concept that IL-23 might be a pro-carcinogenic mediator, detected in KS lesions, probably favoring the progression of the tumor.
KEY WORDS: Sarcoma; Kaposi; interleukin-23; tumor microenvironment.
Assessment of formation of the Glyoxal and Methylglyoxal Levels in Various Sugar-Free or Sweetened Products under in Vitro Gastrointestinal Digestive System
Authors: ANDAÇ-ÖZTÜRK Serap , EDE-CINTESUN Elif , YAMAN Mustafa
Published: March 2024

This study aimed to determine the formation of glyoxal (GO) and methylglyoxal (MGO) in various sweetener-containing products under in vitro digestion. Products obtained from different markets in Istanbul, Turkey. The amount of GO and MGO was determined by High-Performance Liquid Chromatography using pre-column derivatization. Initial GO and MGO values were ranged between 21.1-234.4 µg/100 g and 109.7-3164.5 µg/100 g for GO and MGO respectively. After digestion formation of GO and MGO were increased up to 2546% and 607.9%, respectively. Biscuit sample had the highest GO and MGO values, whereas, after digestion, the wafer exhibited the highest formation rate; both result may be related to high fat content, low moisture and, high heat treatment. Our results revealed that sweetener-containing products such as diabetic jams, chocolate, candy, had high GO and MGO content and this content may increase with digestion. Further studies examining the effects of different sugar types on GO and MGO formation are needed.
DARCY FORCHHEIMER FLOW OF WILLIAMSON FLUID PAST A STRETCHING SHEET WITH VARIABLE THERMAL CONDUCTIVITY
Authors: Ahmed Sahin , Das Bikash
Published: March 2024

The primary objective of this experiment is to examine the motion of molecules of Williamson micropolar fluid moving along a stretchable sheet set in a porous regime with microrotation in presence of magnetic field. The coupled partial differential equations are converted into a system of ODEs using appropriate similarity transformations. To solve the system of ODEs, BVP4C solver has been employed with relative tolerance of . To make sure the present study is stable and convergent, all the outcomes are compared to the earlier findings. The impression of various parameters on velocity, temperature and microrotation profile are illustrated with the help of graph. The graph of entropy generation and skin friction and Nusselt number is also plotted against various governing parameters. Through this investigation it is found that Nusselt number can be increases by regulating the porous parameter and the viscosity of the Williamson fluid. The drag at the surface can be minimized by increasing the strength of magnetic field and Williamson fluid parameter. The implication of this study can be found in industrial field where entropy of the system plays an important role for better performance and stability.
Analisis Pembelajaran Dengan Desain Didaktik Sharing Task dan Jumping Task pada Materi Persilangan Monohibrid
Authors: Adawiyyah Yayu , Irvani Asep Irvan
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengetahui penerapan rancanganÂ  desain didaktik pada pembelajaran dengan menggunakan sharing task dan jumping task dalam materi persilangan monohibrid. Ada tiga kegiatan siswa yang diungkapkan, yaitu: 1) aktivitas kolaborasi siswa dalam kelompok, 2) responss siswa dan 3) hasil diskusi. Penelitian dilakukan terhadap siswa kelas IX A SMP Negeri 1 Cisurupan, Tahun Pelajaran 2021/2022. Hasil penelitian menunjukkan bahwa terdapat peningkatan aktivitas kolaborasi siswa dalam pembelajaran, memperlihatkan responss yang baik dalam setiap tahapan pembelajaran dan mengelola hasil diskusi.
Konsep Profesionalisme Guru Menurut Qs Al-Baqarah 31 (Analisis Ilmu Pendidikan Islam)
Authors: Mohammad Nasrullah Yufi , Rahman Aulia
Published: March 2024

Dalam suatu studi yang dilakukan oleh Heynemen dan Loxley dalam Dedi Supriadi menyebutkan bahwa 29 ditemukan data lebih dari sepertiga proses pendidikan tergantung guru. Di negara berkembang menjelaskan 34% kontribusi guru terhadap prestasi peserta didik, 22% manajemen, 18% waktu belajar, dan 26% sarana fisik. bahkan dinegara maju kontribusi guru 36%, manajemen 23%, waktu belajar 22%, dan sarana fisik 19%.Â  Bisa dikatakan bahwa guru tersebut telah menjalankan profesinya secara profesional. Sejalan dengan itu al-Qurâ€™an pun membahas tentang seorang guru yang profesional yakni dalam QS Al-Baqarah ayat 31. Tujuan dari penulisan ini adalah untuk mengetahui bagaimana konsep dari guru profesional itu ditinjau dari beberapa aspek, pertama ditinjau dalam perspektif ilmu pendidikan Islam, kedua ditinjau dari para mufassir, dan yang ketiga ditinjau dalam perspektif surat al-Baqarah ayat 31 itu sendiri. Penulisan ini merupakan penelitian kepustakaan (library research) dengan pendekatan kualitatif. Penelitian ini berupaya untuk mengumpulkan data atau karya tulis ilmiah yang bertujuan untuk pengumpulan data yang bersifat kepustakaan. Metode yang digunakan peneliti adalah metode kualitatif.Guru yang profesional dituntut untuk bisa mengembangkan potensi peserta didiknya baik dari aspek kognitif nya, afektif nya, maupun dari aspek psikomotoriknya. Guru dituntut mempunyai kualitas ketika membahas suatu materi ajar kepada anak didiknya. Hal itu sejalan dengan nilai-nilai pendidikan yang diajarkan oleh al-Qurâ€™an. Para mufassir menjelaskan bahwa QS al-Baqarah ayat 31 ini menjelaskan tentang keutamaan Nabi Adam dengan diajarkannya berbagai nama-nama benda maupun bahasa yang tidak diajarkan kepada para malaikat.
ANALISIS LAPORAN KEUANGAN MENGGUNAKAN METODE LIQUIDITY RATIO PADA PT PERUSAHAAN GAS NEGARA TBK PERIODE 2020-2021
Authors: Gizta Aulia Dewi
Published: March 2024

Abstract

The purpose of this study was to examine the financial statements of PT Perusahaan Gas Negara Tbk using the Liquidity Ratio method for the 2020-2021 period. This method is used to assess a company's financial performance in terms of liquidity, capital structure, profitability and operational efficiency. The data for this study were collected from the financial statements of PT Perusahaan Gas Negara Tbk for two years. This research includes qualitative descriptive research. The findings show that PT Perusahaan Gas Negara Tbk experienced an increase in its liquidity ratio during the 2020-2021 period. The company's liquidity is getting better as indicated by the increase in the Current Ratio, Acid Test Ratio, and Cash Ratio. In closing, PT Perusahaan Gas Negara Tbk showed an increase in financial performance in the 2020-2021 period. The results of this analysis can assist company management in making the right decisions regarding managing the company's financial resources and improving their financial performance in the future.

Keywords: Financial Statement Analysis, Liquidity Method

 

Abstrak

Penelitian ini bertujuan untuk menganalisis laporan keuangan PT Perusahaan Gas Negara Tbk menggunakan metode Liquidity Ratio, selama periode 2020-2021. Metode analisis ini digunakan untuk mengevaluasi kinerja keuangan perusahaan dalam hal likuiditas, struktur modal, profitabilitas, dn efisiensi operasional. Penelitian ini mengumpulkan data dari laporan keuangan PT Perusahaan Gas Negara Tbk selama periode dua tahun. Jenis penelitian yang dilakukan adalah penelitian deskriptif kualitatif. Hasil ini menunjukkan bahwa PT Perusahaan Gas Negara Tbk mengalami perbaikan dalam rasio likuiditas selama periode 2020-2021. Likuiditasnya perusahaan meningkat, ditunjukkan oleh peningkatan Current Ratio, Acid Test Ratio, dan Cash Ratio. Kesimpulannya, PT Perusahaan Gas Negara Tbk menunjukkan perbaikan kinerja keuangan selama periode 2020-2021. Hasil analisis ini dapat digunakan oleh manajemen perusahaan untuk mengambil keputusan yang lebih baik dalam mengelola sumber daya keuangan perusahaan dan menigkatkan kinerja keuangan mereka di masa mendatang.

Kata Kunci : Analisis Laporan Keuangan, Metode Likuiditas
ANALISIS TARIF SEWA KAMAR MENGGUNAKAN METODE NILAI JUAL RELATIF (STUDI PADA CK HOTEL & CONVENTION CENTRE TANJUNGPINANG)
Authors: Geraldine Saskia
Published: March 2024

Penelitian   ini   bertujuan   untuk   menghitung   pengalokasian   biaya   bersama berdasarkan tarif sewa perjenis kamar yang terdapat di CK Hotel & Convention  Centre Tanjungpinang dan untuk mengetahui kamar jenis mana yang memberikan kontribusi laba terbesar. Data yang digunakan dalam penelitian ini adalah data primer yaitu wawancara dan observasi, dan data sekunder yaitu kepustakaan. Dalam teknik wawancara, peneliti mewawancarai 2 orang narasumber yang mengetahui informasi terkait tarif sewa kamar, tingkat hunian kamar dan, biaya-biaya produksi kamar.Berdasarkan pada hasil penelitian mengenai pengalokasian biaya bersama tarif sewa kamar menggunakan metode nilai jual relatif, maka diperoleh harga pokok produk bersama tertinggi yaitu, Presidential Suite Room sebesar Rp. 6.028,8 dan harga pokok produk bersama terendah yaitu, Standard Room sebesar Rp. 742,925.- Produk bersama yang memberikan kontribusi laba bruto terbesar adalah Presidential Suite Room yaitu sebesar Rp. 127.754.684.- dan produk bersama yang memberikan kontribusi laba terendah adalah Premier Room sebesar Rp. 45.709.146.- Berdasarkan hasil penelitian dan pembahasan mengenai alokasi biaya bersama berdasarkan tarif sewa kamar, total laba yang dihasilkan ditahun 2019 adalah sebesar Rp. 679.123.218.-