bluuebunny/crossref_metadata_2025 huggingface dataset:
Global Down-regulation of Gene Expression Induced by Mouse Mammary Tumor Virus (MMTV) in Normal Mammary Epithelial Cells
Authors: Ahmad Waqar , Panicker Neena G. , Akhlaq Shaima , Gull Bushra , Baby Jasmin , Khader Thanumol A. , Rizvi Tahir A. , Mustafa Farah
Published: May 2023

Mouse mammary tumor virus (MMTV) is a betaretrovirus that causes breast cancer in mice. The mouse mammary epithelial cells are the most permissive cells for MMTV, expressing the highest levels of virus upon infection and being the ones later transformed by the virus due to repeated rounds of infection/superinfection and integration, leading eventually to mammary tumors. The aim of this study was to identify genes and molecular pathways dysregulated by MMTV expression in mammary epithelial cells. Towards this end, mRNAseq was performed on normal mouse mammary epithelial cells stably expressing MMTV, and expression of host genes was analyzed compared with cells in its absence. The identified differentially expressed genes (DEGs) were grouped on the basis of gene ontology and relevant molecular pathways. Bioinformatics analysis identified 12 hub genes, of which 4 were up-regulated (Angp2, Ccl2, Icam, and Myc) and 8 were down-regulated (Acta2, Cd34, Col1a1, Col1a2, Cxcl12, Eln, Igf1, and Itgam) upon MMTV expression. Further screening of these DEGs showed their involvement in many diseases, especially in breast cancer progression when compared with available data. Gene Set Enrichment Analysis (GSEA) identified 31 molecular pathways dysregulated upon MMTV expression, amongst which the PI3-AKT-mTOR was observed to be the central pathway down-regulated by MMTV. Many of the DEGs and 6 of the 12 hub genes identified in this study showed expression profile similar to that observed in the PyMT mouse model of breast cancer, especially during tumor progression. Interestingly, a global down-regulation of gene expression was observed, where nearly 74% of the DEGs in HC11 cells were repressed by MMTV expression, an observation similar to what was observed in the PyMT mouse model during tumor progression, from hyperplasia to adenoma to early and late carcinomas. Comparison of our results with the Wnt1 mouse model revealed further insights into how MMTV expression could lead to activation of the Wnt1 pathway independent of insertional mutagenesis. Thus, the key pathways, DEGs, and hub genes identified in this study can provide important clues to elucidate the molecular mechanisms involved in MMTV replication, escape from cellular anti-viral response, and potential to cause cell transformation. These data also validate the use of the MMTV-infected HC11 cells as an important model to study early transcriptional changes that could lead to mammary cell transformation.
Proposing Clinicopathological Staging and Mitotic Count as Prognostic Factors for Canine Soft Tissue Sarcomas
Authors: Cardoso de Almeida Moreira Andrea , Franzoni Mayara , dos Anjos Denner , César-Jark Paulo , Nóbrega Juliano , Laufer-Amorim Renée , Valsecchi Henriques Marina , Neto Osmar , Fonseca-Alves Carlos
Published: May 2023

Soft tissue sarcomas (STSs) are a heterogeneous group of malignant mesenchymal tumors with similar histological features and biological behaviors. They are characterized by a low to moderate local recurrence rate and low metastasis, affecting approximately 20% of patients. Although this tumor set is vital in veterinary medicine, no previous unified staging system or mitotic count has been associated with patient prognosis. Therefore, this study proposed a new clinicopathological staging method and evaluated a cut-off value for mitosis related to the survival of dogs affected by STS. This study included 105 dogs affected by STS, treated only with surgery, and a complete follow-up evaluation. The new clinicopathological staging system evaluated tumor size (T), nodal involvement (N), distant metastasis (M), and histological grading criteria (G) to categorize the tumor stage into four groups (stages I, II, III, and IV). The proposed tumor staging system was able to differentiate patients’ prognoses, with dogs with stage IV disease experiencing the lowest survival time and dogs with stage I disease having the highest survival time (p < 0.001). Moreover, we assessed the median mitosis (based on mitotic count) and its association with overall survival. Our study’s median mitosis was 5, and patients with ≤5 mitoses had a higher survival time (p = 0.006). Overall, the proposed staging system and mitotic count seemed promising in the prediction of patient prognosis.
Understanding the Climate Change and Land Use Impact on Streamflow in the Present and Future under CMIP6 Climate Scenarios for the Parvara Mula Basin, India
Authors: Mohseni Usman , Agnihotri Prasit G. , Pande Chaitanya B. , Durin Bojan
Published: May 2023

Understanding the likely impacts of climate change (CC) and Land Use Land Cover (LULC) on water resources (WR) is critical for a water basin’s mitigation. The present study intends to quantify the impact of (CC) and (LULC) on the streamflow (SF) of the Parvara Mula Basin (PMB) using SWAT. The SWAT model was calibrated and validated using the SWAT Calibration Uncertainty Program (SWAT-CUP) for the two time periods (2003–2007 and 2013–2016) and (2008–2010 and 2017–2018), respectively. To evaluate the model’s performance, statistical matrices such as R2, NSE, PBIAS, and RSR were computed for both the calibrated and validated periods. For both these periods, the calibrated and validated results of the model were found to be very good. In this study, three bias-corrected CMIP6 GCMs (ACCESS-CM2, BCC-CSM2-MR, and CanESM5) under three scenarios (ssp245, ssp370, and ssp585) have been adopted by assuming no change in the existing LULC (2018). The results obtained from the SWAT simulation at the end of the century show that there will be an increase in streamflow (SF) by 44.75% to 53.72%, 45.80% to 77.31%, and 48.51% to 83.12% according to ACCESS-CM2, BCC-CSM2-MR, and CanESM5, respectively. A mean ensemble model was created to determine the net change in streamflow under different scenarios for different future time projections. The results obtained from the mean ensembled model also reveal an increase in the SF for the near future (2020–2040), mid future (2041–2070), and far future (2071–2100) to be 64.19%, 47.33%, and 70.59%, respectively. Finally, based on the obtained results, it was concluded that the CanESM5 model produces better results than the ACCESS-CM2 and BCC-CSM2-MR models. As a result, the streamflow evaluated with this model can be used for the PMB’s future water management strategies. Thus, this study’s findings may be helpful in developing water management strategies and preventing the pessimistic effect of CC in the PMB.
Detection and Quantification of Pharmaceutical Residues in the Pest County Section of the River Danube
Authors: József Tibor , Kiss Szonja Réka , Muzslay Ferenc , Máté Orsolya , Stromájer Gábor P. , Stromájer-Rácz Tímea
Published: May 2023

Active substances detected in surface water in Hungary today include pain and anti-inflammatory agents and antiepileptics, as wastewater treatment mechanisms cannot remove these micropollutants. The aim of our research is to detect residues of four pain-killer drugs—naproxen, nimesulide, diclofenac, and ibuprofen—and an anti-epileptic drug—carbamazepine—in water samples we collected (n = 8) from the Danube. Our samples were concentrated using solid-phase extraction and then detected with HPLC. During the evaluation, we looked for a significant difference in the concentration of the active substances. Naproxen was detectable in the largest amount in one sampling point, with an average concentration of 12,029.337 ± 1772.957 ng/L, while ibuprofen was present in the second highest concentration in another sampling site, which reached an average concentration of 4048.112 ± 2086.789 ng/L. We examined water samples taken from the same sampling sites but at different distances from the riverbank, and we found a significant difference regarding the active substance naproxen at the sampling site in Budapest District XX. The analytes were detected in varying amounts in all the water samples, so the contamination in the examined section is significant. Examining the turnover data on medicines and our results, we concluded that pharmaceutical consumption significantly contributes to the pollution of the Danube. In order to protect water quality, further research would be advisable in the field of mechanisms for wastewater treatment in order to achieve the complete removal of drug residues from wastewater.
(DES)ENCONTROS DAS ADAPTAÇÕES DA 9ª PARA A 7ª ARTE
Authors: De Araujo Gilvan Charles Cerqueira
Published: April 2023

As adaptações de quadrinhos para o cinema tem sido uma marca da sétima arte nas últimas décadas. Após sucessos como os filmes orignais de Supermam, em 1978, e Batman, em 1989, muitas  e novas experiêncais de adaptações foram apresentadas. O filme Batman v Superman: Dawn of Justice, de 2016, marca a chegada do encontro dos maiores herois da DC comics ao cinema, de forma divisiva e controversa, entre fãs e críticos. Distenciamentos simbólicos, equívocos narrativos e desencontros marcarm essa produção hollywoodiana, as quais serão tratadas nesse artigo, que se propõe a problemátizá-las, e propor reflexões sobre seu impacto, especialmente entremeio de adaptatções da nona para a sétima arte.
CRYPTOACTIVES TAXATION AND LEGAL LIMITATIONS OF THE ECONOMIC POWER
Authors: Baeta Neves Matsushita Mariana Barboza
Published: April 2023

This paper has as its goal to analyze taxation of cryptoactives and the legal limits of the economic power. The paper proposition consists in pointing out the main questions about this problematic, aiming to pin point how the lack of regulation on cryptoactives can undermine the rule of law, as well as legality, neutrality and tax equality. Therefore, in the first topic, are regarded a bundle of decisions from the regulatory agencies, namely, the Economy Ministry – Ministério da Economia - branches, as well as the Central Bank – Banco Central - from the legal perspective to extract concrete and objective definitions. In the second topic, an exposition about the rationale of the Federal Revenue Office of Brazil – Receita Federal- about the topic was made, in order to highlight that despite the lack of regulation, Cryptoactives have a tax outcome defined by this Economy Ministry branch. In the third topic, two academic manifestations about Cryptoactives taxation are analyzed, showing the schism between the legal dogmatic and the rationale built by the Federal Revenue Office. Finally, in the fourth topic, is shown that the lack of legal definitions suited for cryptoactives can be harmful both for the State and tax payers.
NARRATIVAS DE MULHERES NEGRAS NO YOUTUBE
Authors: Gomes Maria Lucia Adriana Silva , Leite Amanda Maurício Pereira
Published: April 2023

O objetivo central desta pesquisa é identificar como mulheres negras se autorrepresentam em canais do YouTube e compreender suas narrativas na contemporaneidade. No âmbito do objeto de estudo, é desenvolvida a partir de um conjunto de sete vídeos produzidos e publicados pelo YouTube Brasil, com narrativas de Camila Nunes, Gabi Oliveira, Luci Gonçalves, Mari Ribeiro, Nátaly Nery, Tia Má e Ramana Borba. As publicações integram a campanha YouTubeBlack, em comemoração ao dia da Consciência Negra no país, no ano de 2017. O aporte teórico escolhido foram os Estudos Culturais, uma vez que a abordagem sob essa perspectiva indica que artefatos culturais podem produzir novos comportamentos sociais. O trabalho também propõe uma reflexão sobre as heranças escravocratas do período colonial, a construção da representação social e da identidade da mulher negra no Brasil. Com base nos ensinamentos de Kozinets (2014), por se tratar de uma pesquisa de campo on-line que se dedica à interpretação de fenômenos que acontecem a partir da interação de pessoas no mundo virtual, utilizou-se como estratégia metodológica a netnografia. Para a análise dos dados, também empregou-se como método a análise de narrativas, a partir do plano da metanarrativa, proposto por Motta (2013). A apreciação dos relatos sob esse aspecto possibilita a percepção de temas ou motivos que levam o narrador a expressar-se da forma que o fazem e a compreensão mais profunda da estrutura social e dos modelos de mundo nas quais estão inseridos. A análise do material demonstrou que representação, representatividade, interseccionalidade e feminismo negro são temáticas que se entremeiam no decorrer das falas das sete entrevistadas e que, algumas vezes, surgem implicitamente
Compilation of sops, amendments considering changing environment
Authors:   SBHI Samara Regional Clinical Hospital named after V. D. Seredavin, Samara, Russia, Golovnina E. E. , Ubina A. A. ,   SBHI Samara Regional Clinical Hospital named after V. D. Seredavin, Samara, Russia, Shalashova N. Yu. ,   SBHI Samara Regional Clinical Hospital named after V. D. Seredavin, Samara, Russia, Murtazina D. M. ,   SBHI Samara Regional Clinical Hospital named after V. D. Seredavin, Samara, Russia
Published: May 2023

The impact of changing conditions (the pandemic, changes in the regulatory framework, new resources) on the organization of professional development of nursing staff is considered. The need for standardization of nursing manipulations (introduction of SOPs) is justified. Making changes and additions taking into account the changing situation is presented on a specific example.
Some aspects of international practice of studying the transition to cultivation and legal sale of wild medicinal plants (literature review)
Authors:   Medical University ", Golikova N. S. ,   Reaviz",   , Moscow
Published: May 2023

Lately, the use of medicinal plants and herbal preparations for the prevention and treatment of diseases has been increasing in all parts of the world. The traditions of using herbal preparations are supported by the latest research on the isolation of active components from medicinal plant raw materials, the development of new assay, purifi cation technologies and those of extraction of active substances, the standardization of methods and technologies, the appearance of new pharmaceutical laboratory and factory equipment. The range of plants used for medical purposes is expanding, the range of indications for medical use is expanding for traditionally harvested plants. All mentioned factors lead to an increase in the economic potential for the development of the raw materials base of medicinal plants. At the same time, more and more attention is paid to the ecological approach to harvesting of wild plants, there are cases of damaging the raw materials base of plants due to unregulated harvesting, and of other environmental consequences. In addition, uncontrolled trade and application of plants for medical purposes can lead to negative consequences for human health. The article shows examples of studying the harvesting and distribution of wild medicinal plant raw materials and the possibilities of its cultivation and sale under controlled conditions.
Validación del potencial antioxidante de Citrus aurantium en Tabasco, México
Authors: Villarreal_Ibarra E.C. , Cadenas-González M.T , Méndez- Morales F , Bolio-López G.I , Hernández-Villegas M.M , Rivera- López N.E , Almenares-López D. , Rivas Morales C
Published: May 2023

Citrus aurantium L. (Rutaceae), commonly known as bitter orange, has multiple therapeutic potentials. An experimental qualitative study was carried out with the objective of knowing the characteristics of the consumption of C. aurantium (CA) in the Tabasco population. To validate its use, an ethanolic extract (85 %) was prepared from the dry CA leaves and phytochemical screening was performed, with subsequent quantification of the content of total phenols and flavonoids. Subsequently, antioxidant activity was determined by the DPPH assay and acute toxicity with Artemia salina. The most used parts of the plant are the leaves to relieve muscle pain, cold symptoms. In the phytochemical study it was found that the extract contains alkaloids, flavonoids, coumarins, quinones and tannins. In the thin layer chromatography of the hydroalcoholic extract, the presence of naringin was demonstrated. A total phenol content of 69.42 ± 3.47 EAG/g DM and total flavonoids of 14.78 ± 0.28 EQ/g DM were obtained. It contains antioxidant activity of 9240 ± nmol TEAC/gMS and the acute toxicity test showed moderate toxicity. The results show that the 85% ethanolic extract contains phenolic compounds and flavonoids, allowing to sustain the medicinal and pharmacological properties conferred to the plant in the state of Tabasco.Conclusions: this study showed the existence of phenols and flavonoids, the antioxidant activity of hydroalcoholic extracts from C. aurantium leaves and their moderate toxicity against Artemia salina.
The impact of nursing practice environments on patient safety culture in primary health care: a scoping review protocol
Authors: Pereira Soraia Cristina de Abreu , Ribeiro Olga Maria Pimenta Lopes , Fassarella Cintia Silva , Santos Eduardo José Ferreira
Published: May 2023

Background

Patient safety is a key priority for healthcare organisations. It impacts directly on patient health and wellbeing. The increasing complexity of current healthcare settings, which are associated with high work demands and increasingly stressful professional practice environments, contributes to an increased likelihood of errors and adverse events. Primary health care, given its comprehensiveness of care, makes up a large proportion of the care delivered to the population.

Aim

To map the knowledge about the impact that nursing practice environments have on safety culture in the primary healthcare setting. This knowledge is essential for a more effective and appropriate understanding of this phenomenon and to enable the definition of strategies that can promote the provision of safer care to the population.

Design & setting

A scoping review will be conducted based on the method proposed by the JBI, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) will be used.

Method

Study selection, data extraction, and synthesis will be performed by two independent reviewers. Based on the Population (or participants), Concept, and Context (PCC) framework, this scoping review will consider studies that address nurses' practice environment and patient safety culture in primary health care. The review will consider all studies, published or unpublished, from 2002 to the present.

Conclusion

The results from this scoping review are expected to provide an overview of the importance of the nursing practice environments on patient safety culture, which will be crucial to define an appropriate range of strategies to promote the delivery of the safest health care to the population.
Hidrogeoquímica de las aguas minero medicinales de la provincia de Melgar, Puno-Perú
Authors: Chui Betancur Heber Nehemias , Pérez Argollo Katia , Roque Huanca Edgar Octavio , Callohuanca Ávalos Edgar Darío , Trigos Sánchez Lily Maribel , Mamani Gamarra Javier Elias
Published: May 2023

Las aguas minero-medicinales de la provincia de Melgar de la región de Puno en Perú, se encuentran ubicadas a gran altitud, con utilidad medicinal y/o de recreación, por lo que es necesario conocer sus características, en tal sentido el estudio tuvo el propósito de identificar las características hidrogeoquímicas de las aguas minero medicinales de la provincia de Melgar, Puno en Perú. Para el estudio se ha recolectado información de los parámetros físicos y químicos de los pozos minero medicinales de la provincia de Melgar, Puno. Se aplicó la técnica de los diagramas de Piper con la finalidad de caracterizar los tipos de agua minero medicinales. Los resultados indicaron que, el catión predominante en las pozas de Pasanoccollo; Santa Rosa; Huamanruro; Andaymarca y Pojcpoquella, fue el ión Na+, con 84,33%; 56,35%; 50,60%; 64.16% y 73.97% de presencia, respectivamente, mientras que, en la poza de Macarí el catión que más predominó es el Ca2+ con 42.54 %. Con respecto a los aniones el SO_4^(2-) y el Cl- son los aniones que predominaron. El Cl- fue el anión predominante en las pozas de Santa Rosa; Huamanruro; Macarí; Andaymarca y Pojcpoquella con 74.43 %; 67.22 %; 58.57 %; 58.34 % y 70.79 % de presencia, respectivamente, mientras que en la poza de Pasanoccollo el anión que predominó es el SO_4^(2-)  con un 58.37 %, de estos resultados se llega a la conclusión que las pozas se encuentran en un marco estratigráfico y estructural de las aguas minero medicinales, está formado por areniscas rojas y rocas conglomeradas.
The Representation Concept of Hell Punishment in Islamic Teachings in the comic Indahnya Taman Surga, Pedihnya Siksa Neraka
Authors:   Master Design Study Program, Universitas Komputer Indonesia, Kasmana K , Hikmah E N ,   Visual Communication Design Study Program, Universitas Komputer Indonesia
Published: May 2023

Indahnya Taman Surga Pedihnya Siksa Neraka, one of the religious comics present in Indonesia. This comic reaps the discourse of the debate because it is considered to present violence and pornography, on the other hand, this comic offers the teachings of life and cosmology according to Islam. This research seeks to find a representation of the concept of the torment of hell in the Islamic teachings present in the comic visual. Comparative studies were conducted between Islamic teachings through the interpretation of the Quran Hamka version, as well as the content of torture present in the visuals embodied in the comics. Interpretation brings the result that the comic provides narrative development by making variations, additions, simplifications, and reductions influenced by the comic's background without changing the main idea of the source. Comics show the comic's belief in Islamic teachings, including in interpreting his belief that there will be a hell of a version of himself.
Media Convergence and Implication of Television Digitalization Creates a Change Audience Behavior
Authors:   Departemen Visual Communication Design, Universitas Komputer Indonesia, Indonesia, Tarmawan I
Published: May 2023

Media creates mass audiences and a strong influence as a social control that shapes media influence seen from the social conditions that occur. Technological developments that have triggered media convergence have given birth to new media which is increasingly difficult to place media as social control. The convergence of media and the implications of digitalization of television on changes in audience behavior are interesting parts to be researched. The research method used is a qualitative descriptive case study with the paradigm of developing media analysis from institutions to formats based on content and form and to audiences based on social constructs. The purpose of this study is to determine whether media convergence affects the mass media during the transition period as an implication of digitalization of television in Indonesia and changes in public behavior. The results show that digital technology has triggered media convergence to create new, easily accessible media. The slow migration of digitalisation caused by various factors and regulations encourages stakeholders to use the internet to create new media, the melting of mass media into a new platform that has a positive impact on changes in audience behavior in easy access to information.
National Museum of Indonesia : Virtual Tour Experience
Authors:   Interior Design Department, Design Faculty, Universitas Komputer Indonesia, Bandung, Indonesia, Nazhar Ryanty Derwentyana
Published: May 2023

This article aims to discuss the implementation of exhibition spaces in virtual tour museums in Indonesia. The case study taken is the National Museum of Indonesia, the largest museum in Indonesia and has many collections. In 2020 the Covid-19 pandemic occurred globally, including in Indonesia, which limited activities in public facilities. One of the effects of this incident was the closure of museum facilities. The National Museum of Indonesia is one of the museums that has finally opened an online virtual tour facility to deal with the ongoing Covid-19 pandemic problem. In the exhibition interior design science, there are several elements and design systems applied to get the things they want when visiting an exhibition, including getting clear information and education and experiencing the recreation obtained from space's activities and atmosphere. The virtual exhibition space will undoubtedly be different from the conventional exhibition space. The research carried out a method by collecting data based on a survey of 121 respondents, who conducted a virtual tour of the museum directly and assessed the room's situation and the clarity of the information obtained. This study's results are in the form of experiences experienced and felt by visitors, which can be used as input for the improvement of the virtual tour of the National Museum of Indonesia in particular, and museums in Indonesia in general.
Study of the Elements Design Interactive of Student in Solar System Physics lessons through the Interactive Compact Disk (CD) of Solar System Physics Lab
Authors:   Departemen Desain Komunikasi Visual, Universitas Komputer Indonesia, Indonesia, Cahyadi A T
Published: May 2023

Multimedia can combine elements of text, sound, images, animation, and video via a computer or digitally manipulated elements that are conveyed or controlled interactively. Interactive multimedia in this learning can be a learning solution in the digital era to stimulate the thinking power of students. The purpose of this study was to determine the interactive multimedia element theory test used in the Interactive CD of Solar System Physics Lab as an electronic learning medium. This research method was carried out using a descriptive qualitative approach regarding the results of the study of the interactive multimedia design structure on the Interactive CD of Solar System Physics Lab, with case studies of researchers investigating carefully a program, event, activity, process, or group of individuals. Data processing techniques through literature study, group discussions, and interviews. The results of this study will determine the elements of interactive multimedia on the interactive CD of Solar System Physics Lab, which can be used as an example for e-learning media, the Solar System Physics Lab has used the Multimedia development process flow according to the procedure.
Reflections of Levant and Mesopotamia gods and goddess on Cyprus cylinder seals
Authors: Yazgin Yücel
Published: April 2023

The aim of the research is to determine the similarities between the Cyprus and Levant & Mesopotamian cylinder seals, on which god and goddess figures are engraved on them. The research is important in terms of showing the effects and similarities of mainland cultures and artistic products through Levant & Mesopotamian mainland and Cyprus island cultures. The research stems from a case study model, which will involve qualitative research methods. Visual analysis was carried out in two stages. In the first stage, 67 seal images were given to six creative education experts. Experts stated that there are figures of a god and goddess on 34 cylinder seals. In the second stage, 34 seal images were examined by three visual arts experts. The infographic analyses have shown that the god-goddess figures on the Levant & Mesopotamian and Cyprus cylinder seals are similar or bear close resemblances. This result shows that ancient civilisations shared the material and spiritual values of the culture in a "fluid and sticky" character. This sharing feature should be accepted, supported and protected as a guide to the way of living together, which today's people need.
Measuring corporate M&A performance from a two-dimensional perspective of economic and social benefits
Authors: Liu Kui
Published: April 2023

With the development of digital economy, Chinese companies have set off waves of M&A boom. The current mainstream methods of measuring corporate M&A are based on corporate finance level such as event study method and financial analysis method. Based on the literature research method, this paper points out the problems of the relatively single perspective and narrow scope of the measurement of M&A based on corporate finance. To this end, this paper uses the hierarchical analysis method (AHP) to comprehensively measure the economic and social benefits of M&A enterprises from the perspective of corporate finance and social contribution, constructs a corporate M&A performance evaluation model, and establishes a corresponding evaluation index system to promote a more comprehensive, scientific and reasonable measurement of M&A enterprise performance and promote sustainable development of enterprises.
Ways of implementing information technologies in professional training of future specialists
Authors: Shunkov Vasyl , Marushko Larysa , Mykhailov Viktor , Lutsenko Yurii , Teslenko Svitlana
Published: April 2023

Creation of modern effective technologies, automation, intensification of production, implementation of planning and management with the help of modern information and communication technologies are the main factors of acceleration of scientific and technical progress. The purpose of the article is to show the importance of using information technologies in the training of future specialists. Without the integration of the educational environment of the higher school into the informational educational environment, without the exit of the educational process into the global information space, significant development of modern educational systems is impossible. In order to substantiate the principles of improving the professional training of education seekers, a quantitative analysis of open educational resources is proposed, the most popular platforms on which the path to open educational resources is designed are determined. The article examines the conditions by which the effectiveness of pedagogical support is achieved in the distance learning process. The substantiation of the most essential criteria and indicators involves the assessment of the quality of personality education in the digital educational space. They offer the perfect use of digital information, readiness for communication, critical thinking, digital and social competence.
Features of training specialists using innovative approaches
Authors: Knysh Inna , Tiahur Liubomyra , Ivanova Victoria , Vasiutynska Yelena , Shovsh Kateryna
Published: April 2023

The article examines the peculiarities of training specialists through the use of innovative approaches. The article shows the methodological concept of purposeful formation of competitive specialists in the process of professional training, which represents the main innovative approaches to the study of the problem of training specialists. The purpose of the research is revealed, in which the peculiarities of the training of specialists using innovative approaches are revealed. Two types of these approaches to high-quality training of specialists are identified. The innovative approach in education is considered through the use of the proposed model and through the ability to design and model the programmed educational process in a higher education institution with the mandatory application of various innovative approaches. The authors highlight the main components of educational innovation in the article. Prospective directions of educational innovation are highlighted. The necessity of applying innovative approaches in the system of education of future specialists is proven and the need for active assimilation of educational information is shown, the development of key competencies, professional growth and ensuring the competitiveness of future specialists on the labor market in the modern world are proven. The main innovative technologies in education, which have recently been introduced into the practice of higher education, are considered.
Organizational and legal provision of the control function of the local self-government body in conditions of sustainable development
Authors: Chernadchuk Tamara , Kozachok Inna , Maletov Dmytro , Pankratova Viktoriia , Steblianko Alina
Published: April 2023

The article discusses the issue of organizational and legal support of the control function of the local self-government body in the conditions of sustainable development in Ukraine. The functions of local self-government in Ukraine were outlined. The essence of the control function of local self-government bodies has been studied. The authors performed an analysis of the legislation defining the control powers of local self-government bodies and carried out its relationship with the goals of sustainable development. The purpose of this article is to define and characterize the control function of the local self-government body and its relationship with the goals of sustainable development. Various methods were used in the article, namely: historical method, method of documentary analysis, formal-legal, system-structural. Thus, with the help of the system-structural method, information on the relationship between the legally defined functions of local self-government bodies and the goals of sustainable development was systematized, which contributed to increasing the complexity, systematicity and completeness of the research. Thanks to this, it was possible to conclude that after the reform of the local self-government institute, which consisted in decentralization, the local self-government bodies gained additional control powers, which, as a result, strengthened sustainable development in the localities.
Integrating mobile assisted language learning (MALL) into EFL classes at a tertiary level
Authors: Yucedal Hur Mustafa
Published: April 2023

Mobile Assisted Language Learning (MALL) practices have gained increasing popularity thanks to the advancements in mobile technologies. Accordingly, a growing number of initiatives have been taken to integrate it into language learning process. However, a gap in the literature has been observed to measure the effects of MALL on students’ writing competence at a tertiary level in Iraq. To this aim, it was sought to pinpoint the influence of MALL on 60 Language Preparatory School students’ writing competence at TISHK International University by employing snowball sampling technique within 12 weeks in 2021-2022 Academic Year. The study was conducted in an Academic Writing course that required the students to write an essay weekly. The data were collected via exams, a questionnaire, an interview and a survey which were analyzed either by SPSS 23. or MAXQDA software applications in this mixed methods design study. Control group students received a traditional instruction, while experimental group students were trained based on the procedure of MALL. The findings unearthed that MALL practices increased students’ marks dramatically, boosted students’ motivation and increased students’ overall attitudes towards learning English. The findings of this study can have some implications for the educators who consider the implementation of MALL practices at educational institutions.
Sistemas de informação aplicados à área da saúde
Authors: De Paiva Luiz Fernando Ribeiro , Laranjo Rafael Bisinotto , De Castro Filho Ricardo Gomes , Paiva Adriana Pontes
Published: May 2023

Desde as últimas décadas do século XX, as Tecnologias Digitais da Informação e Comunicação (TDICs) têm alterado a forma como se realizam as inúmeras atividades humanas. O uso dessas tecnologias trouxe uma série de avanços relativos à facilidade, agilidade e eficácia com as quais são realizados inúmeros processos. Na área da saúde, as TDIC possibilitaram, por exemplo, novas formas de realização de diagnósticos e de outros procedimentos, transformando-se em aliadas no aumento da expectativa de vida e na melhoria da qualidade do atendimento aos pacientes. As tecnologias digitais estão também presentes nos processos de gestão de hospitais, clínicas e consultórios, proporcionando agilidade nos atendimentos. Destaca-se, também, o uso da Internet na busca de informações sobre novos cuidados e orientações para a prevenção de doenças, bem como para a pesquisa sobre tratamentos inovadores. O presente artigo apresenta uma análise da evolução das tecnologias digitais aplicadas à área da saúde a partir de levantamento bibliográfico e análise de informações de sites especializados.
Effect of Land Use on Water Erosion Override Impacts Associated with Climate
Authors: Chen YaMin , Song XiaoDong , Liu Feng , Dong Yue , Zhang Chu , Ye MingLiang , Zhang GanLin
Published: May 2023

Anthropogenic activities have dramatically changed land uses over the last century, which has considerably increased soil disturbance. Despite considerable attention paid to the effects of land use on soil erosion, it remains controversial as to how much land use and climate contribute to erosion. In this study, we conducted a comprehensive meta-analysis of 1,380 measurements from published studies using the
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Cs method to examine the responses of erosion to land uses and climatic variables across terrestrial ecosystems in China. Our results showed that land use had significant impacts on the rate of erosion, with the lowest rates on natural and bamboo forests and the highest rates on farmland. Land use change of forest and grassland to farmland significantly increased erosion. Erosion rates respond significantly but differently to climatic variables in varying land use types. Correlations of erosion rates with mean annual temperature and precipitation were negative in forest ecosystems, positive in farmland, and nonsignificant in grassland. Variance partition analysis showed that land use types explained more of the variation in erosion rates than did environmental variables at a broad geographic scale, such as climate. This study highlights the importance of land use in affecting erosion rate. Incorporating these evidences into global erosion models may improve the simulation of long-term soil dynamics.
Para una comprensión de las fuentes jurídicas
Authors: Tejada Martinez Diego M.
Published: April 2023

Esta investigación proporciona herramientas conceptuales de análisis para abordar la comprensión de la doctrina de las fuentes del derecho: a partir del eje conceptual fuentes del derecho-unidad del derechopráctica jurídica se alcanza un entendimiento de las tradicionales fuentes jurídicas que revela su vital importancia para la práctica jurídica e intelección de derecho como un fenómeno constitutivamente unitario y práctico. Finalmente, con base en el análisis del Artículo 410 de la Constitución de Bolivia, se explicita el fenómeno legal que hoy en día domina la producción de las normas jurídicas y sin el cual ya no es posible comprender cabalmente la teoría clásica de las fuentes del derecho; nos referimos al conjunto de normas constitucionales (la Constitución) como primera fuente jurídica; o en otros términos: la incidencia radical que tiene el proceso de constitucionalización de los ordenamientos jurídicos en la comprensión de las fuentes del derecho.
RESPON PERTUMBUHAN DAN HASIL TANAMAN TERONG TERHADAP PENGGUNAAN MEDIA TANAM DAN DOSIS PUPUK ORGANIK
Authors: BUDIYANI NI KOMANG , APRIASTUTI NI PUTU EKA , DWIPRADNYANA I MADE MAHADI
Published: May 2023

Eggplant is a vegetable group that is in great demand by various groups due to its delicious taste and high nutritional content and complete composition. The purpose of this study was to determine the response of eggplant growth and yield to the use of growing media and doses of organic fertilizers. The study used a randomized block design (RBD) with 2 factors, namely the planting medium which consisted of 4 levels, namely M0, M1, M2, M3 and the dose of organic fertilizer consisted of 4 levels, namely P0, P1, P2, P3.The results showed that the planting medium affected several parameters, including plant height (M1), number of leaves (M2), number of fruit (M3), and fruit weight (M2). And the organic fertilizer dose treatment significantly affected the parameters of the number of leaves (P2) and the number of fruits (P3).
Radiation levels of isolation rooms used by radio-iodine ablation patients during hospitalization
Authors: Waqar Muhammad , Afridi Touqir Ahmad , Soomro Quratulain
Published: April 2023

The use of RAI-131 in thyroid carcinoma patients presents a special concern on the environmental radiation safety for those who come in contact with the patients especially after discharge from the facility because of excretion of I131 through perspiration, salivation, breathing and urination. Methods & Materials: The present study was conducted at Nuclear Medicine Oncology and Radiotherapy Institute Nawabshah (NORIN) Sindh from 2017 to 2021 with the objective to evaluate contamination hazards by Excretion made by thyroid cancer patients received iodine therapy stayed in isolation room with doses ranging from 80–200 mCi. The areas included corridor, sink, patient bed, and toilet bowl of isolation rooms before admission and after discharge using LAMSE RM-1001 survey meter. The minimum background radiation level measured before patient stay in isolation room was 0.07 μSv/h while the maximum was 0.40 μSv/h and the mean background reading was 0.18 ± 0.072 μSv/h. The maximum dose rate after discharge was observed at toilet bowl with mean of 9.69 ± 1.98 µSv/hr and minimum of 5.0 µSv/hr and maximum value 13.77 µSv/hr. The readings recorded for the sink were: 2.0 μSv/h minimum, 20.0 μSv/h maximum with a mean of 5.55 ± 1.57 μSv/h while those for the patient bed 0.41 μSv/h minimum, 6.92 μSv/h maximum and a mean of 2.83 μSv/h. the least dose rate was found in isolation room corridor (1.53 ± 0.78 μSv/h) with maximum and minimum values 0.28 & 3.20 μSv/h respectively. Radiation is harmful; safety measures must be ensured to minimize radiation exposure to the family members as well as community either during hospitalization or after discharge of RAI-131 patients. The radiation levels from toilet bowls, beds, sinks, and corridor of isolation rooms were well within the acceptable limits and hence, do not pose significant hazard to the public
The Accidental Beauty of the Productive Landscape
Authors:   Washington University in St. Louis, Van Dyck Murphy Kelley
Published: May 2023

The Midwestern agricultural landscape is a tapestry shaped by natural and artificial forces. From above, patterns of use mani¬fest through grids, infrastructural lines, and irrigation circles, superimposed with other natural or manmade features. These patterns can be seen as expressions of our cultural values: layered compositions of regulation, agricultural production, and environmental conditions. Aerial imagery captures the complex interaction of natural and human logics by taking these patterns, formed without compositional intention, and presents them as cultural artifacts. This paper seeks to probe these accidental compositions as objects of reflection through the investigation of the production of aerial imagery, the adoption of landscape patterns in both art and architecture, and the exploration of these superimpositional techniques. Of particular interest are art and architectural practices that explore the tense relationship between man and environment through a reinterpretation of the captured landscape. Works by artist Andrea Zittel, photographer David Thomas Smith, and visual effects artist Aydin Buyuktas are considered as case studies that provide a critical context for the author’s public art installation, 3_6_._9_°,_ _-_8_9_._6_°. This project reinterprets the forms and patterns of the Midwestern agricultural land¬scape as a field of play. This installation, comprised of portions of discarded carpet, is inhabitable as drawing, surface, and representation of the landscape of Southeast Missouri. Here, the aerial landscape is a composition of values, and, applied to a vertical surface presents those values in a new light.
Design Logics: A Diagrammatic Approach to Research and Representation of Health Pathways in the Built Environment
Authors:   University of Virginia, Somers Schaeffer
Published: May 2023

Frameworks to conceptualize and evaluate programs in public health can be adapted as tools to guide research and contribute to the visual culture of architecture. One such framework is a logic model, a graphic tool that details specific components of an intervention and the proposed short and long-term outcomes. The logic model is a cornerstone of program planning and evaluation, a systematic method for collecting, analyzing, and using data to examine the effective¬ness of a specific program and to understand why it may or may not be working as planned. The tool has been used to assess the health outcomes of plans, policies, and projects in urban planning through a methodology called Health Impact Assessment (HIA). The collaborative research process to develop a logic model has the potential to play a more generative role in architectural design. In this paper, I explore methods to bring the logic modeling process into design pedagogy and to promote potential applications in integrative design practices. Three examples are examined: 1) a logic model used in a comprehensive HIA of a community development project, 2) visualization of scientific research, and 3) a logic model representing a solution for an intergenerational health center in a design competition. Logic models can play a significant role in the design, evaluation, and monitoring of health outcomes in architectural projects at any scale and level of complexity. The work will demonstrate the potential of using logic models to conceptualize projects from the earliest stage of development to support integrative and collaborative research methods in design.
Plug and play: A versatile CURE Curriculum for Scientific Process Skills in Upper Division Life Science Labs
Authors: Sawiccy Valeri , Cai Jun B. , Maruyama Shumpei , de Leonardi Noah Silva , Weis Virginia M. , Kirk Nathan L.
Published: April 2023

Despite the favorable student outcomes and call to increase opportunities for undergraduate research experiences, many students do not have the opportunity to engage in traditional research experiences. Undergraduate institutions are increasing efforts to integrate course-based undergraduate research experiences (CUREs) into undergraduate curricula, however, allocating time for instructors to develop materials is a significant barrier to implementing CUREs in life science laboratories. To streamline the process of developing and implementing CUREs, we present a versatile multi-week curriculum that reinforces scientific process skills and complements a variety of life science CURE research projects conducted in upper-division laboratory courses. By broadening the participation of students in scientific research and facilitating students in essential elements of scientific inquiry, this CURE curriculum can maximize both academic research milestones and student educational gains.