bluuebunny/crossref_metadata_2025 huggingface dataset:
The dynamics of the levels of cytoplasmic HSP70 and chloroplast HSP70B chaperones under heat stress differs in three species of pumpkin with different resistance to stress
Authors: Murtazina N. D. , Sharapova L. S. , Yurina N. P.
Published: January 2025

The first line of defense in plants under stress is the cell chaperone system. In this work, we studied the effect of heat stress on the levels of cytoplasmic chaperones HSP70 and HSP70B in chloroplasts of three species of Cucurbita (C. maxima Duchesne, C. pepo L. and C. moschata Duchesne), which differ in resistance to stress. A relationship has been established between the levels of chaperones HSP70 in the cytoplasm and HSP70B in chloroplasts and the species of pumpkin plants under heat stress conditions. Under stress, a significant increase in the level of chaperones was observed in the cells of pumpkin plants C. maxima – the level of HSP70 in the cytoplasm increased by 3.6 times, and the level of HSP70B in chloroplasts – by two times. Heat stress caused a 1.7-fold increase in the level of the cytoplasmic chaperone HSP70 in the cells of C. pepo pumpkin plants, but no significant change in the level of the HSP70B protein was noted. However, as a result of the effect of heat stress on C. moschata pumpkin plants, a decrease in the levels of HSP70 and HSP70B was revealed compared to untreated plants. The dynamics of changes in the levels of chaperones in the cytoplasm and chloroplasts under the influence of heat stress are similar. It should be noted that the constitutive level of HSP70 and HSP70B under normal conditions in C. moschata and C. repo is higher than in C. maxima. Analysis of the data obtained revealed an interesting pattern: high constitutive levels of HSP lead to insignificant induction of HSP and vice versa – low constitutive level of these proteins correlates with high induction of these proteins after heat stress. The data obtained are important for understanding the mechanisms of plant resistance to stress and can be useful for the selection and creation of highly resistant productive varieties of agriculturally important plants.
Metabolic-associated fatty liver disease in elderly patients
Authors:   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, BEYLINA N. I. , POZDNYAK A. O. ,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, SUBKHANKULOVA S. F. ,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia
Published: January 2025

The purpose — to evaluate the clinical manifestations of metabolic-associated fatty live disease (MAFLD) in primary care patients.

Material and methods. The study involved 22 men and 78 women with MAFLD examined on an outpatient basis. They underwent anamnesis assessment, anthropometry, determination of body mass index (BMI); ultrasound examination (ultrasound) of the liver; determination of cholesterol, glucose, and cytolysis markers (ALT, AST).

Results. Among the patients, 48.7% of women and 22.7% of men had elevated cholesterol levels (p > 0.05). Hyperglycemia was noted in 25.6% of women and 9.1% of men (p > 0.05). Mild cytolysis (up to 3 ALT norms) was recorded in 17.9% of women and 9.1% of men (p > 0.05) Hyperechoic liver was detected in 96% of women and 100% of men (p > 0.05), an increase in liver size in 43.6% and 59%, respectively (p > 0.05). Excess body weight/obesity was detected in 79.5% of women and 72.7% of men (p > 0.05). Among women, disorders of carbohydrate metabolism — DM2 and prediabetes — were detected more often than among men (34.6 and 9.1%, p < 0.05). The relationship between DM2 and obesity can be traced only in women. Excess body weight and obesity of various degrees were detected in 72.2% of women with DM2 and 88.9% of women with prediabetes (p > 0.05). The prevalence of hypertonic disease (HD) was found to be widespread among both men (86.4%) and women (66.7%) (p > 0.05). Coronary heart disease (CHD) was in the anamnesis of 3.8% of women and 22.7% of men (p < 0.05); 9.1% of men had suffered a myocardial infarction. As for concomitant diseases, cholelithiasis (CL) was found in 21.8% of women and 13.6% of men (p > 0.05).

Conclusion. Among patients with MAFLD, women predominate. Disorders of fat and carbohydrate metabolism and CL are more often detected in women and HD, CHD, GERD in men, which must be taken into account when diagnosing and correcting risk factors for MAFLD.
Time before primary percutaneous coronary intervention in patients with favorable and fatal outcomes due to ST-segment elevation myocardial infarction
Authors:   Kazan State Medical University, IVANTSOV E. N. , KHUSAINOVA A. A. ,   Kazan State Medical University, KHAMADULLINA I. F. ,   Kazan State Medical University, KIM Z. F. ,   Kazan State Medical University, KHASANOV N. R. ,   Kazan State Medical University
Published: January 2025

ST-segment elevation myocardial infarction (STEMI) is an acute life-threatening condition that requires urgent, complex, well-coordinated treatment, aimed primarily at the earliest possible reperfusion. The adverse effect of delay to reperfusion on the prognosis of in-hospital mortality in patients with STEMI was demonstrated with both thrombolysis and PPCI in the 1996–2004 studies. More recent data are inconsistent regarding the association of adverse hospital outcomes with time to PPCI.

The purpose was to examine the time from the onset of pain in ST-segment elevation myocardial infarction to primary percutaneous coronary intervention in association with the hospitalization outcome.

Material and methods. For the study, we selected 177 records of patients with a fatal outcome and 380 records of patients discharged with a favorable outcome of myocardial infarction with ST-segment elevation from Kazan Emergency Care Center for patients with acute coronary syndrome. The study included 349 men and 208 women from 32 to 96 years old; the median age was 67 (58–76) years.

Results. The time from the onset of pain syndrome (PS) to the primary medical contact (PMC) in patients with a lethal and favorable outcome did not differ significantly and amounted to 180 (75–540) and 168 (88–450) minutes, respectively (p = 0.639). From the moment of PMC to the registration of the first ECG in patients with a fatal outcome, 26 (19–36) minutes passed, and in patients with a favorable outcome, 25 (17–40) minutes (p = 0.747). From the registration of the first ECG to hospitalization in patients with a fatal outcome, 42 (35–60) minutes passed, in patients with a favorable outcome 48 (40–60) minutes (p = 0.041). The time from hospitalization to primary PCI was 60 (45–104) minutes in patients with a fatal outcome and 60 (45–91) minutes in patients with a favorable outcome (p = 0.981).

Conclusion. In patients with STEMI, the time from the pain onset to the first medical contact, from the first medical contact to the first electrocardiogram, from the first electrocardiogram to the hospital door and from the hospital door to balloon inflation during PPCI does not differ significantly in patients with a favorable and fatal outcome.
Clinical and anamnestic risk factors for recurrent pelvic organ prolapse
Authors:   Peoples’ Friendship University of Russia, Orazov M. R. , Radzinskiy V. E. ,   Peoples’ Friendship University of Russia, Minnullina F. F. ,   Kazan (Volga) Federal University
Published: January 2025

The incidence of pelvic organ prolapse (POP) in women is increasing worldwide, and experts predict that the trend will continue until 2050. The only available and effective treatment for POP is surgical correction, but it is associated with a high recurrence rate and the need for reoperation. Since it is not feasible to reduce the primary POP incidence, efforts should be directed at preventing recurrence in women with pre-existing dysfunction treated for POP. The outcome of POP surgical correction may depend on both medical tactics and clinical and anamnestic risk factors for POP recurrence.

The purpose — to analyze the data on clinical and anamnestic risk factors reliably associated with recurrent pelvic organ prolapse.

Material and methods. We analyzed the results of scientific papers published and posted in the Cochrane Library, PubMed, ELibrary, and Science Direct electronic libraries between 2014 and 2024 using the keywords: pelvic organ prolapse, risk factors, recurrence.

Conclusions. Based on the analysis, it should be noted that the available understanding of risk factors for POP recurrence is extremely insufficient and contradictory. Identification of significant risk factors of POP recurrence will allow improving preoperative preparation, choice of optimal surgical technique and further management of patients.
Acute disseminated encephalomyelitis in children: clinical features, diagnostics, outcomes
Authors:   Republican Children’s Clinical Hospital, AKHMETGALEEVA N. F. , LYUTOV O. V. ,   Bashkir State Medical University, BAKHTIYAROVA K. Z. ,   Bashkir State Medical University
Published: January 2025

The article presents an analysis of data on children with a first-time demyelinating episode who were initially diagnosed with ADEM. In most cases, the diagnostic search was complicated by an atypical clinical picture and imperfections in diagnostic methods. A thorough examination of patients is necessary, as well as differential diagnosis with other CNS diseases, timely pathogenetic therapy to prevent residual neurological deficit, and long-term dynamic observation of patients.

The purpose — to analyze the first demyelination episode in children, to assess the severity of the patient’s condition and remote outcomes.

Material and methods. Data of 19 patients observed at the Children’s Center for Neuropsychiatry and Epileptology of the Republican Children’s Clinical Hospital (Ufa) from 1994 to 2024. Statistical analysis was performed in Statistica 22.0.

Results. 19 children with a first demyelination episode were observed. Girls predominated among the patients. The first demyelination episode occurred more often in children of middle school age. In 10 patients, the first demyelination episode was preceded by a viral infection, in 3 children the fact of injury was recorded, in one child the disease was preceded by a DPT revaccination. In other patients, no factors triggering the disease onset were identified. Common infectious symptoms were often observed — 10 children; motor dysfunction was observed in 15 children, oculomotor disorders — 6, ataxia — 6, pelvic organ dysfunction — 4, epileptic seizures — 2, hearing and vision loss — 1, pseudobulbar disorders — 1. 11 children (57.8%) had only brain damage at their debut, 7 (36.8%) had brain and spinal cord damage, and 1 child (5.2%) had only spinal cord damage. In eight children, the initial diagnosis of ADEM was revised.

Conclusions. It is important to apply diagnostic criteria at the first demyelination episode to establish a correct diagnosis. In order to prevent the development of persistent neurological disorders, timely therapy is necessary.
Features and structure of anemia in case of myocardial infarction
Authors:   Voronezh State Medical University named after N.N. Burdenko, NEDOMOLKINA S. A. , PASHKOVA A. A. ,   Voronezh State Medical University named after N.N. Burdenko, VELIKAYA O. V. ,   Voronezh State Medical University named after N.N. Burdenko, KOTELNIKOVA T. E. ,   «RZhD-Meditsina» Clinical Hospital, VELIKIY A. V. ,   «RZhD-Meditsina» Clinical Hospital
Published: January 2025

Anemia is a pathological condition accompanied by a decrease in the concentration of hemoglobin and/or the number of red blood cells per unit volume of blood. According to numerous clinical studies, anemia occurs in 10-80% of patients with cardiovascular pathology (CVP). The significant variability in the incidence of anemia in CVP is explained by the heterogeneity of the anemia causes; varying degrees of severity of cardiovascular diseases and different comorbidity in the subjects. In acute coronary syndrome (ACS), concomitant anemia is considered as an independent predictor of the risk of adverse outcomes and an almost fourfold increase in patient mortality.

The purpose was to study the hemoglobin level in patients with myocardial infarction, who were treated in the Cardiology Department of «RZhD-Meditsina» Clinical Hospital from 2013 to 2023. We selected 224 cardiological case histories, of which 154 were men and 70 women. The average age of the patients was 64.5 ± 11.9 years. Anemia was detected in 60 patients (27%), of which 34 (57%) were women and 26 (43%) men. Anemia of mild severity was detected in 54 (90%) of patients, moderate in 4 (7%), severe in 2 (3%). The etiology of anemia was determined in 33% of cases: 13% had iron deficiency anemia (IDA), 10% anemia of chronic disease (ACD), 7% had posthemorrhagic anemia. Megaloblastic anemia was observed in 3% of patients, without differential diagnosis of the causes. The incidence of anemia in myocardial infarction was 27%, while in women it was 1.3 times more common. Most of the anemias were of mild severity; absolute (AID) and functional (FID) iron deficiency prevailed.
Obesity in children and adolescents in the Republic of Tatarstan: medical and statistical analysis
Authors:   Сhildren’s Republican Clinical Hospital, SHAIDULLINA M. R.
Published: January 2025

The article analyzes statistical indicators of obesity in children and adolescents in Tatarstan in 2010–2023. The author studied the endocrine pathology and demonstrated a high proportion of obesity in its structure. The research showed an elevation in the prevalence and morbidity of both endocrine pathologies and obesity. Evidence of the relationship between statistical indicators of obesity and the quality of preventive medical care is provided.
Efficacy of shear wave elastography in assessing uterine scar after cesarean section
Authors:   Ural Research Institute of Maternity and Childhood, NESTEROV V. F. , MALYGINA G. B. ,   Ural Research Institute of Maternity and Childhood, KOSOVTSOVA N. V. ,   Ural Research Institute of Maternity and Childhood
Published: January 2025

A scar on the uterus is a central problem of modern obstetrics. The use of shear wave elastography makes it possible to determine the elasticity of the scar tissue on the uterus and its adequacy.

The purpose — to evaluate the efficiency of using ultrasonic shear wave elastography in diagnosing the condition of the uterine scar from a caesarean section (CS).

Material and methods. The study included 63 pregnant women with an uterine scar from a caesarean section, who were divided into 2 groups according to the intraoperative state of the scar: group 1 (main group) — 19 patients with an «inferior» uterine scar, group 2 (comparison group) — 44 patients, with an «adequate» uterine scar. Before delivery, in addition to conventional ultrasound examination, ultrasonic shear wave elastography was performed, and the stiffness coefficient was determined. Correlation analysis of the most significant ultrasonic markers with the state of the scar according to the histological examination was carried out.

Results. It was established that ultrasound diagnostics plays an important role in assessing the state of the uterine scar. According to the results of a traditional examination, the most significant marker of an inferior uterine scar is the «hyperechogenicity» of the lower segment, which was naturally more common in patients of the main group. Carrying out ultrasonic shear wave elastography made it possible to determine the stiffness coefficient of the lower segment, which was 2 times higher in patients of the main group. A significant correlation was found between an inferior uterine scar from a caesarean section and an increased stiffness coefficient (r = 0.43, p = 0.03; 95% confidence interval 12.4–17.3). Histological examination of excised scars showed that inferior scars on the uterus were represented by immature connective tissue, with an abundance of fibroblasts.

Conclusion. Sufficiently high reliability of elastographic study data allows regarding it as an informative method for assessing the state of the uterine scar after cesarean section.
Role of insulin resistance in predicting premature placental abruption
Authors:   Bashkir State Medical University, LAZAREVA A. YU. , FATKULLINA I. B. ,   Bashkir State Medical University, SAGATDINOVA E. A. ,   Republican Clinical Hospital named after G.G. Kuvatov, DALAEVA T. KH. ,   Republican Clinical Perineal Center
Published: January 2025

Premature detachment of a normally located placenta is an extremely severe complication of pregnancy, which is characterized by suddenness and peracute development, and the consequences of this condition can sometimes be irreparable. Placental abruption is one of the major obstetric syndromes, along with preeclampsia and fetal growth retardation, the pathogenesis of which is based on the so-called ischemic placental disease. Placentation disorders are associated with endothelial dysfunction, and insulin resistance is a morphological substrate of this pathology, along with other predictors. It is important to note that impaired glucose tolerance is the scourge of our time, so this topic is especially relevant.

The purpose — to evaluate insulin resistance as a predictor of premature detachment of the placenta.

Material and methods. 87 women were examined, who were divided into two groups: the main group with a history of placental abruption, and the control group without such history. The respondents were examined for insulin resistance using the HOMA-IR index.

Results. Insulin resistance markers were detected in patients with a history of placental abruption.

Conclusion. Insulin resistance can be considered as one of the predictors of premature detachment of the placenta.
Neonatal listeriosis of the newborn
Authors:   Omsk State Medical University, PUZYREVA L. V. , RUSINOVA T. G. ,   Regional Clinical Hospital, GOLOVANOVA YU. E. ,   Regional Clinical Hospital, DVORZHETSKAYA O. V. ,   Regional Clinical Hospital, PATYUKOV A. G. ,   Omsk State Medical University, KONSTANTINOVA A. YU. ,   Regional Clinical Hospital
Published: January 2025

Listeriosis is a forgotten but formidable infection for a pregnant woman, fetus and newborn. The clinical picture of the disease depends on the characteristics of the organism. The pregnant woman may experience premature labor, non-viable pregnancy, or miscarriage. For a newborn, Listeria monocytogenes can be fatal. We offer a description of a clinical case of neonatal listeriosis in a premature girl at 32 weeks with deep hypoxia, cerebral ischemia and respiratory distress syndrome. The child was promptly delivered to a specialized department, where treatment was carried out at several stages. Microbiological examination confirmed intrauterine infection of the newborn with Listeria monocytogenes. Positive dynamics in clinical and laboratory data were achieved against the background of antibacterial therapy.
Comparative characteristics of the course of ischemic and hemorrhagic stroke against the background of arterial hypertension
Authors:   Smolensk State Medical University, BAZINA I. B. , KOZYREV O. A. ,   Smolensk State Medical University, IPPOLITOVA L. A. ,   Smolensk State Medical University, GULAKOVA K. A. ,   Smolensk State Medical University, MOLOTKOVA S. A. ,   Smolensk State Medical University, PAVLOVA M. V. ,   Smolensk State Medical University
Published: January 2025

Arterial hypertension (AH) is the main cause of ischemic and hemorrhagic strokes, which are considered, along with myocardial infarction, the leading cause of mortality from cardiovascular diseases. The unity of cardio-cerebral pathology has been proven, which is based on mechanisms and criteria that make it possible to compare and assess the prognosis of ischemic and hemorrhagic stroke.

The purpose — to compare biochemical and hemodynamic parameters of ischemic and hemorrhagic strokes and their possible impact on disease outcomes.

Material and methods. Medical records of patients treated in the Department for patients with acute cerebrovascular accident (ischemic and hemorrhagic stroke) were analyzed.

Results. 132 41–90 y. o. patients were examined, of them 92 people with ischemic stroke, 40 with hemorrhagic stroke. Among the risk factors for ischemic stroke were: diabetes mellitus — 15.2%, permanent atrial fibrillation — 21.7%, post-infarction cardiosclerosis — 8.7%, smoking — 3.3%, hypercholesterolemia — 68.3%, hypertension — 100% of patients. 3.3% of patients died. In hemorrhagic stroke: hypertension — 100% of patients, permanent atrial fibrillation — 17.5%, post-infarction cardiosclerosis — 7.5%, smoking — 8.7%, diabetes mellitus — 17.5%, recurrent stroke — 2.5%, hypercholesterolemia — 80% of patients. 50% of patients died (p ≤ 0.05). In hemorrhagic stroke, compared with ischemic one, dyslipidemia was more pronounced, fibrin, fibrinogen values were increased, systolic blood flow rate in the internal carotid artery was increased, glomerular filtration rate was reduced, which may indicate an unfavorable prognosis of the disease. This is supported by the high mortality in the hemorrhagic stroke group.

Conclusion. Hemorrhagic stroke is less common than ischemic one, but it is much more severe, accompanied by high mortality of patients in the acute period of the disease. The severity of the course of hemorrhagic stroke, compared with ischemic one, is due to more pronounced disorders of the lipidogram and coagulogram, a decrease in the rate of glomerular filtration, and an increase in the rigidity of the vascular wall.
Construction of Modified Carbon Paste Electrodes for Determination of Tramadol in Very Trace Amounts
Authors: Ali Muthana S.
Published: January 2025

This research includes estimating the drug (Tramadol Hydrochloride, TR) using the potentiometric method by constructing selective electrodes for TR drug with the active ingredient (Ammonium Reinackate, AR) using a plasticizer (Nitro benzene, NB) and adding nanomaterials (Multi wall carbon nanotube (MWCNT), Nanosilica) for carbon paste electrodes to increase selectivity and sensitivity towards the material to be estimated. The results showed that the manufactured electrodes were able to estimate tramadol hydrochloride in the pharmaceutical preparation (tramadol tablets) at very low concentrations (trace amounts) up to 5.0×10-6 M using the direct and standard methods and proved to have a wide linear range up to 1.0´10-8 - 1.0´10-2 M. The Nernstatine slope of the prepared TR-AR-NB electrodes is (58.027, 58.251, and 58.694 mV/decade) for Carbon Paste Electrodes (CPE), MCPE (MWCNTs) and MCPE (MWCNTs+ nanosilica), respectively. The lower detection limit (LDL) is 2.39×10-7 M for the CPE and 4.98×10-8 M for the MCPE (MWCNTs) and 4.7384×10-9 M for the electrode MCPE (MWCNTs+ nanosilica) which makes it eligible for the estimation of tramadol hydrochloride in very low concentrations. The study included measuring the selectivity of these electrodes with the presence of interferers where the values ​​of Ki,jpot for all studied species were less than 1. The drug was identified in both urine and blood plasma, with a recovery of at least 99.309 for urine and 97.6593 for blood plasma.
Manajemen Pondok Pesantren di Era 5.0: Mengoptimalkan Pendidikan Berbasis Teknologi dan Inklusi
Authors: Fahrurrozi Imam , Juwari Juwari , Aris Masruchi Zainal
Published: January 2025

Pondok pesantren, sebagai lembaga pendidikan tradisional di Indonesia, perlu mengalami transformasi yang signifikan untuk menghadapi era 5.0. Pada era 5.0 ini perlu adanya integrasi teknologi digital dalam semua aspek kehidupan, termasuk didalamnya adalah manajemen pendidikan di pondok pesantren. Penelitian ini bertujuan untuk menganalisis manajemen pondok pesantren yang dapat dilakukan guna mengoptimalkan pendidikan pondok pesantren di era 5.0. Metode penelitian yang digunakan adalah metode kepustakaan yakni dengan mengumpulkan serta menganalisis berbagai sumber literatur yang berupa artikel jurnal, buku, ataupun penelitian sebelumnya. Hasil penelitian ini menunjukkan bahwa dalam beradaptasi dengan era 5.0 manajemen pondok pesantren perlu menekankan inovasi, inklusi, dan pengembangan yang berkelanjutan. Diantaranya dengan transformasi Manajemen di Pondok Pesantren, Teknologi dalam Pengelolaan Administrasi dan Komunikasi, Inklusi dan Diversitas dalam Pendidikan, dan Pendidikan Karakter sebagai modal kesiapan abad 21. Dengan mengintegrasikan teknologi, mendorong inklusi, dan memperkuat kolaborasi, pondok pesantren dapat memainkan peran yang lebih besar dalam mempersiapkan generasi muda untuk menghadapi masa depan yang semakin kompleks dan berubah dengan cepat. Transformasi ini bukan hanya tentang meningkatkan efisiensi operasional, tetapi juga tentang menghasilkan lulusan yang berdaya saing tinggi dan berkomitmen pada nilai-nilai keislaman dan kemanusiaan yang mendalam.
Empowering Future Leaders: The Role of Religious Institutions in Addressing Social Issues Through Training and Community Engagement
Authors: Purwanto Edi
Published: January 2025

Religious institutions are pivotal in addressing social issues, acting as agents of spiritual guidance and societal transformation. This study examines a community service program at Victory Theological College, designed to prepare future religious leaders through an integrated approach to theological education and practical social engagement. The program encompassed three phases: interactive training on social justice and contemporary issues, hands-on field practice addressing real-world challenges, and reflective evaluations to assess impact and learning. Participants demonstrated significant improvement in understanding the dual role of religious institutions in providing social aid and advocating for justice. Field activities included initiatives to combat poverty, promote racial reconciliation, foster gender equality, advocate for environmental stewardship, and support human rights. Reflective discussions highlighted the program’s success in connecting theological principles with practical solutions, preparing leaders to navigate complex social realities. The study underscores the transformative potential of combining faith-based education with community engagement, offering a replicable model for fostering justice, compassion, and sustainable development through religious institutions.
PENGUATAN KAPASITAS UMKM TERHADAP PERIZINAN BERUSAHA, SERTIFIKAT HALAL DAN DIGITALISASI PEMASARAN DI KELURAHAN BUGIS KECAMATAN DUMBO RAYA KOTA GORONTALO
Authors: Imran Mohammad , Farid  , Putalan Reinal
Published: January 2025

Tantangan yang dihadapi UMKM di Kelurahan Bugis Kecamatan Dumbo Raya Kota Gorontalo, diantaranya keterbatasan pengetahuan tentang perizinan usaha, rendahnya tingkat kepatuhan terhadap sertifikasi halal dan minimnya pemanfaatan teknologi digital untuk pemasaran. Oleh karenanya, kegiatan ini bertujuan untuk memberikan pemahaman dan penguatan kepada Pelaku UMKM yang ada di Kelurahan Bugis Kecamatan Dumbo Raya Kota Gorontalo dengan metode: (1) Bimbingan Teknis Pembuatan NIB; (2) Pelatihan dan pendampingan pembuatan akun siHalal dan (3) Sosialisasi terkait digitalisasi pemasaran produk UMKM. Pelaksanaan kegiatan meliputi sosialisasi terkait digitalisasi pemasaran produk UMKM, dilanjutkan dengan pemaparan materi, pelatihan dan bimbingan teknis yang dilaksanakan secara langsung terkait Pembuatan NIB dan pembuatan akun siHalal.  Output kegiatan ini, menumbuhkan kesadaran pelaku usaha UMKM agar memiliki legalitas usaha dengan Nomor Induk Berusaha (NIB) dan sebagai penguatan kapasitas para pelaku usaha UMKM terkait sertifikasi Halal dan Pemasaran produk secara digital.
Von der kindzentrierten Identifikation des sonderpädagogischen Förderbedarfs Lernen hin zur systembedingten Unterstützung im Lernen
Authors: Gebhardt Markus , Koch Jakob
Published: January 2025

Von der kindzentrierten Identifikation des sonderpädagogischen Förderbedarfs Lernen hin zur systembedingten Unterstützung im Lernen
Kleine lernen von Großen – und umgekehrt
Authors: Käpernick Carina , Peddinghaus Lea , Schmidt Anna
Published: January 2025

Wenn Lernstrategien nicht von den Lehrkräften, sondern von älteren Schüler:innen vermittelt werden, haben alle etwas davon. Auch das Gemeinschaftsgefühl wird gestärkt. Über das Lernen-lernen-Projekt am Märkischen Gymnasium Iserlohn.
Lernkompetenztage für selbstgesteuertes Lernen
Authors: Schwarzer Michael , Mai Nelli
Published: January 2025

Um Lernstrategien, aber auch soziale Kompetenzen gezielt über mehrere Jahre hinweg aufzubauen, führt die Joseph-von- Fraunhofer-Schule in München acht Lernkompetenztage pro Schuljahr durch. Das Konzept hat sich bewährt und wird stetig weiterentwickelt.
»Schule ohne Coaching ist möglich, aber sinnlos«
Authors: Ianes Doris , Bergmann Susanne , Büttner Lena
Published: January 2025

Ein Gymnasium in Bayern hat für die Vermittlung von Lernstrategien ein Coaching-Konzept entwickelt, das von der Unterstufe bis zum Abitur reicht. Die Schüler:innen werden altersgerecht darin unterstützt, die für sie passenden Lernstrategien zu finden und zu entwickeln.
Herausforderung Aufmerksamkeit
Authors: Schlegel Reto
Published: January 2025

Etwa 5 Prozent der Schüler:innen sind von ADHS betroffen. Sie benötigen besondere Angebote, um erfolgreich lernen zu können. Dabei geht es vor allem um den Aufbau einer pädagogischen Beziehung. Widerstände und Konflikte gehören dazu.
Mythen in der Schule – Eine Einführung
Authors: Brüning Ludger , Siewert Jörg
Published: January 2025

In der Schule sind vielfältige Mythen zu finden. Oft schränken sie die professionelle Handlungskompetenz von Lehrer:innen zum Nachteil der Schüler:innen ein. Wie entstehen sie? Warum halten sie sich so hartnäckig? Und wie können Lehrkräfte sie aufspüren und ihnen begegnen?
Wie hast du’s mit der Religion?
Authors: Haag Ludwig
Published: January 2025

Klaus Zierer und Thomas Gottfried erklären Ehrfurcht vor Gott zum wichtigsten Bildungsziel.
Klassenführung
Authors: Zierer Klaus
Published: January 2025

Der Faktor des Monats
Super Future Skills im Zeitalter von KI
Authors: Muuß-Merholz Jöran
Published: January 2025

Schlusspunkt
Einen bewussten Umgang mit dem Unbewussten finden? Psychoanalyse als theoretische Perspektive für die empirische sozialpädagogische Professionsforschung
Authors: Janotta Lisa
Published: January 2025

Die Psychoanalyse begleitet den Professionsdiskurs der Sozialen Arbeit seit etwa 120 Jahren und ist doch in Studiengängen und aktueller Professionsforschung kaum repräsentiert. Neben theoretischen Unternehmungen finden sich allerdings auch empirische Studien, die sich der Frage nach sozialpädagogischer Profession(alisierung) in psychoanalytischer Perspektive widmen. Welchen Gewinn bringt die Psychoanalyse für die empirische Professionsforschung in der Sozialpädagogik? Zur Beantwortung dieser Frage werden zunächst psychoanalytische Bezüge des (sozial-)pädagogischen Professionsdiskurses vorgestellt. Anschließend werden empirische Studien diskutiert, die basierend auf den psychoanalytischen Konzepten von Alfred Lorenzer und Jacques Lacan sozialpädagogische Professionalität und ihre Bedingungen untersuchen.
Zum Einsatz von Videographie zur Professionalisierung von Sozialpädagog:innen im schulischen Kontext
Authors: Junker Robin , Hermstein Björn
Published: January 2025

Im Zuge reformerischer Eingriffe in das Schulsystem haben die Etablierung sozialpädagogischer Tätigkeiten und Rollenprofile in den vergangenen Jahren stark zugenommen. Einst als Nebenrolle mit begrenzter Wirkung gesehen, erfahren sozialpädagogische Kompetenzen und Expertisen heute eine zentrale Rolle in der schulischen Bildungsgestaltung, gleichwohl persistieren tradierte interprofessionelle Ambivalenzen auch im Zeitalter der programmatischen Rede von Multiprofessionalität. Der Artikel untersucht, wie sozialpädagogische Ansätze erfolgreich in Schulsysteme integriert werden und wie Videographie als methodisches Werkzeug dienen kann, um angehende Sozialpädagog:innen professionell vorzubereiten. Durch eine detaillierte Analyse von historischen Entwicklungen, rechtlichen Rahmenbedingungen und praktischen Implementierungen beleuchtet der Beitrag die Notwendigkeit von spezialisierten Trainingsmethoden und diskutiert zukünftige Forschungs- und Bildungsperspektiven im Kontext der Sozialen Arbeit in der Schule.
Die maßgebliche Beteiligung der Hilfsschullehrerschaft am Gesetz zur Verhütung erbkranken Nachwuchses
Authors: Hänsel Dagmar
Published: January 2025

Gegenstand des Beitrags ist die maßgebliche Beteiligung der Hilfsschullehrerschaft am Gesetz zur Verhütung erbkranken Nachwuchses (GzVeN) und damit an den rassenhygienischen Bestrebungen im Nationalsozialismus. Das Gesetz wird im Beitrag als Kindersterilisations- und als Sonderschulgesetz dargestellt und die besondere Bedrohung der Hilfsschulkinder aufgezeigt. Die maßgebliche Beteiligung der Hilfsschullehrerschaft am Gesetz wird durch ihre Mitarbeit in den Bereichen Erziehung, sonderpädagogische Diagnostik und Propaganda erwiesen und der Gewinn verdeutlicht, der aus dieser Mitarbeit für die Hilfsschule und die Hilfsschullehrerschaft erwuchs.
Rezensionen
Authors: Niemeyer Christian
Published: January 2025

Rezension zu Shell Deutschland GmbH (Hrsg.) (2024): 19. Shell Jugendstudie – Jugend 2024. Pragmatisch zwischen Verdrossenheit und gelebter Vielfalt.
Entfremdung und Verdinglichung im Kontext von Schule und Unterricht
Authors: Parade Ralf , Epp André
Published: January 2025

Einführung in den Thementeil „Entfremdung und Verdinglichung im Kontext von Schule und Unterricht“
Sechzehn Länder, sechzehn Bestimmungen?
Authors: Kohler Britta , Bohl Thorsten , Hübner Nicolas
Published: January 2025

Vor dem Hintergrund der großen Relevanz schulischer Zensuren für Lebens- und Berufschancen einerseits und der vielfältigen wissenschaftlichen Kritik an ihrer Aussagekraft und Vergleichbarkeit andererseits arbeitet der vorliegende Beitrag aktuelle rechtliche Regelungen der Notengebung in Deutschland vergleichend auf. Hierbei erfolgt eine Fokussierung auf schriftliche und mündliche Leistungen an allgemeinbildenden Gymnasien. Mittels Dokumentenanalyse wird insbesondere eruiert und anschließend diskutiert, welche Leistungen die Grundlage der Fachnoten in den Bundesländern bilden, wie diese bestimmt und gewichtet werden und welche Anforderungen und Kriterien für die Bildung von Fachnoten gültig sind. Die Befunde verweisen bezüglich der rechtlichen Regelungen auf enorme Differenzen zwischen den Ländern, aber auch auf fehlende Spezifizierungen innerhalb von Ländern und variierende Begrifflichkeiten.
Intuitive Handlungsentscheidungen in der pädagogischen Praxis und die Rolle epistemischer Gefühle
Authors: Hermkes Rico
Published: January 2025

Handlungssituationen in der pädagogischen Praxis sind oft durch Komplexität, eine unvollständige Informationslage und Zeitdruck gekennzeichnet. Solche Situationen erfordern von Praktiker*innen rasche Handlungsentscheidungen, die intuitiv erfolgen, d.h. nicht auf explizite Wissensbestände zurückgreifen, sondern implizites Wissen nutzen. In einem solchen Sinne ist Intuition nicht nur als bloßes Instinktverhalten zu verstehen, sondern wird als von rationalen Prinzipien geleitet angenommen. Eine offene Frage dabei ist, wie intuitive Handlungsentscheidungen vom Akteur als valide beurteilt werden können, ohne dass bewusstes bzw. deliberatives Denken an einem solchen Urteilsprozess beteiligt sein muss. Der Beitrag analysiert, auf welche Weise epistemische Gefühle dazu beitragen können, die Validität intuitiver Entscheidungsprozesse zu gewährleisten, und stellt einen inferentiellen Ansatz vor, der expliziert, wie knowing und feeling bei intuitiven Handlungsentscheidungen zusammenwirken.
Cancel Culture among Indonesian Muslims on Social Media
Authors: Nadia Nurfitria
Published: January 2025

This article examines the phenomenon of cancel culture among Muslims in Indonesia, focusing on its manifestation on social media and its impact on divisions and perceptions of Islam. The study highlights prominent cases, including Ahok and Tuan Guru Mizan, which demonstrate how cancel culture fosters polarisation among conservative, moderate, and liberal Muslim groups, while reinforcing negative stereotypes of Islam as intolerant. Using qualitative methods and digital ethnography, I observe and documents the practice of cancel culture through the Trending Topic X and Google Trend features. It explores the dynamics of cancel culture, its implications for freedom of expression, and advocates for a dialogical approach rooted in Islamic values to address these challenges. This study aims to contribute to academic discourse on Digital Humanities within Islamic Studies and underscores the importance of fostering unity within Indonesia’s Muslim society.
Evaluation of Medical Treatment Results in Patients with Giant Prolactinoma Who Previously Underwent Surgery or Not
Authors: Mercan Sarıdaş Filiz , Hocaoğlu Erhan , Yaşar Müge , Karatoprak Kadircan , Öz Gül Özen , Cander Soner
Published: January 2025

In this single-center retrospective study, we aimed to evaluate the results of medical therapy as primary or secondary treatment following surgery and compare follow-up outcomes between the two approaches. Patients were grouped as medical therapy alone (Group M) and surgery plus medical therapy (Group S+M). Patients' demographics, such as age and gender, and age at the diagnosis were recorded. Differences between the pre-and post-treatment tumor size, prolactin (PRL) levels, Knosp grades, tumor response to treatment, improvement in hypofunctions, visual field, and biochemical control were recorded and compared between the two groups. A total of 41 patients diagnosed with giant prolactinomas were included in the study. Hypopituitarism was found in 82.93%, hypogonadism in 80.59%, GH deficiency in 51.22%, ACTH deficiency in 36.59%, and TSH deficiency in 41.46% of the patients. Visual field defects were found by 60.53%. Tumor volume at diagnosis was significantly higher in Group M (p 0.05). This study's results demonstrate no statistically significant difference between medical therapy alone and surgery plus medical therapy regarding the reduction of tumor volume and normalization of PRL values in patients with giant prolactinomas. Surgery should be reserved for severe compression conditions, and potentially unnecessary surgical approaches should be avoided.
Innovative approaches to the creation of semi-finished meat with the addition of vegetable components
Authors: Maikova S. , Romashko I. , Masliychuk O. , Vivcharuk O.
Published: January 2025

The article is devoted to the development of a multicomponent formulation for ready-to-cook meat semi-finished products using plant-based additives such as rosemary extract, kelp powder, and alfalfa. The aim of the study was to enhance the nutritional value, stability, and quality of meat products while reducing dependence on artificial preservatives through the presence of natural antioxidants. The study analyzed the chemical composition of four types of meat raw materials (turkey, rabbit, beef, and beef heart) and the plant components used in the semi-finished products. The research included an analysis of the amino acid and fatty acid composition of the ingredients, which enabled the development of a product formulation balanced in terms of essential amino acids. The high protein content and polyunsaturated fatty acids found in turkey and rabbit meat were taken into account, making these products highly valuable nutritionally. The inclusion of rosemary extract reduced the intensity of oxidative processes, while kelp enriched the product with microelements such as iodine, calcium, and iron. Organoleptic studies revealed that samples containing plant-based additives received the highest ratings for taste, aroma, texture, and appearance. The best results were achieved by a sample containing a combination of rabbit and turkey meat with the addition of rosemary extract, kelp, and alfalfa. The final data confirmed the effectiveness of the proposed formulation, which not only improves the nutritional value of the product but also extends its shelf life without the use of artificial preservatives. The article highlights the potential of using natural plant-based additives in the meat industry to produce products with improved properties that meet modern healthy nutrition standards.
Regulation of proliferative potential: insights into key signaling cascades and te-lomerase functions
Authors: Tolok O. , Malysheva Kh.
Published: January 2025

Cell proliferation is a fundamental biological process that underpins tissue growth, repair, and regeneration, playing a pivotal role in both normal physiology and pathological conditions. The ability of cells to proliferate is intricately controlled by regulatory networks comprising transcription factors, signaling pathways, and telomerase activity. This review delves into the molecular mechanisms that govern cell proliferation, focusing on the critical signaling cascades – PI3K/Akt, MAPK, Wnt/β-catenin, and NF-κB – which orchestrate cell cycle progression and mediate cellular responses to external stimuli. Dysregulation of these pathways is linked to numerous disorders, including cancer, where unchecked proliferation drives disease progression. Special emphasis is placed on Yamanaka factors (OCT4, SOX2, KLF4, c-MYC, NANOG, and LIN28), which are instrumental in maintaining cellular pluripotency and promoting a high proliferative potential. These factors not only reprogram somatic cells into induced pluripotent stem cells (iPSCs) but also enhance regenerative capabilities, making them indispensable tools for tissue engineering and regenerative medicine. Their interaction with core signaling pathways and their ability to influence gene networks highlight their multifaceted roles in cellular biology. Telomerase, a ribonucleoprotein traditionally recognized for its function in telomere maintenance, is revisited in this review for its non-canonical roles. Emerging evidence indicates that telomerase modulates gene expression and interacts with signaling pathways to influence proliferation. These insights expand our understanding of telomerase beyond its established role in genomic stability, positioning it as a key regulator in cellular proliferation and potential therapeutic target. This review synthesizes current knowledge on these mechanisms, emphasizing their interconnectedness and translational potential. By highlighting advances in our understanding of proliferative regulation, the article underscores the therapeutic opportunities in leveraging these pathways for regenerative medicine, tissue engineering, and oncology. The ability to modulate proliferation through targeted interventions offers promise for addressing unmet clinical needs, advancing personalized medicine, and enhancing outcomes in tissue repair and cancer therapies. As research continues to uncover novel roles and interactions within these networks, the potential for developing innovative strategies to control proliferation remains vast, heralding a new era in biomedical science.
Application Of The Green Building Concept In Children's Libraries
Authors: Marsella Vannesa  , Zahrah Wahyuni
Published: January 2025

There is a low rate of literacy in Indonesian society. The poor interest in reading among Indonesians makes this worse. One of the key facilities for enhancing the caliber of human resources is the library. A venue for the dissemination of knowledge is the library. Global developments are significantly influenced by fast-evolving knowledge and technology. As much as 70% of Indonesian pupils, according to a 2018 assessment by the Program for International Pupils Assessment (PISA), have poor reading skills and are unable to identify the main idea of a brief paragraph. With these circumstances, Indonesian libraries are unable to sustain the country's population's desire in reading. To develop reading skills from an early age, this paper will undertake green building research in kid-friendly apartment complexes and libraries and investigate design approaches that utilize these concepts to boost user comfort and productivity. The process involves examining library resources found in both online and print scientific journals. This research develops a green building design concept with several applications, such as integrating green open space on the building site into a central green open space in an exemplary garden, integrating each floor of the building into green open space, maximizing daylight for building lighting during the day, using solar panels to store energy from sunlight, and using filtered rinse water to water plants.
Keywords: children's library, green building, literacy
Strategies for using sustainable urban drainage systems in the architectural design of civil infrastructure projects in Jakarta
Authors: Gbran Hassan
Published: January 2025

The current research is mainly targeting the major challenge of climate change and flood risk in Indonesia (Jakarta) through investigations on suitable methods of sustainable urban drainage systems (SUDS). Through climate scenarios and flood risk assessments, as well as SUDS efficiency appraisals, this study aims at helping stakeholders gain insight on innovative water management strategies. The combination of hydrological models, GIS analysis, and stakeholdersâ€™ engagement is the research approach that will enable the exploration of Jakarta's vulnerability to extreme weather events and introduce mitigation techniques in the form of SUDS. This study aims to address climate changeâ€™s impact on flood risk and develop sustainable design solutions so that the infrastructure in Jakarta can be resilient to flooding. The findings of this research are to provide a basis for decisions, plans, and policies towards green water management regulations and a more water-resilient urban built environment.
Study of Method of Evaluating Surface's Pollution Level & Cleaning Efficiency on Decoration Building Materials
Authors: O Un Gyong , Kim Kyong Chon , Jo Jong Chol
Published: January 2025

In the paper, we analyzed synthetically the research results on methods of testing the cleaning effect on DBM(Decoration Building Materials) and suggested a new Pollution Level & Cleaning Effect Evaluation System(PCEES) on the DBM's surface which is based on image information processing by use of color quantization method and color feature extraction method with HSI (Hue Saturation Intensity) model.
By applying the PCEES to many building objects, we could select the effective composition of cleaning agent and cleaning method and calculate the agent's consumption amount necessary for the building work.
And we suggested the degree of cleaning effect according to the quantitative result values of evaluation on pollution level & cleaning effect to correspond with the empirical judgment of a man.
Interactive Mixed Reality Museum for Ulos Batak Cultural Heritage Preservation and Global Recognition
Authors: Halim Jasmine Meilani , Lubis Dinda Pebriani , Hasibuan Aziz Parham Ramadhan , Syardhi Rizfan Dio , Ningsih Ranti Widya , Alda Tania
Published: January 2025

Indonesia, with its abundant cultural riches, faces challenges in preserving the traditional Batak cloth, Ulos, which is now threatened by globalization and foreign cultural claims. Ulos, which has been designated as Indonesia's Intangible Cultural Heritage (WBTb) since October 17 2014, has not yet received international recognition from UNESCO as part of the Intangible Cultural Heritage (ICH) list. This recognition is very important to increase global awareness about Ulos and the need for its preservation. Considering these challenges, this research proposes the creation of "Ulos Heritage: Mixed Reality-based Interactive Museum" as an innovative solution to preserve and promote Ulos. This museum was designed with an interactive technology approach, using mixed reality to create a memorable and immersive experience for visitors. This approach involves presenting the collection in an appropriate atmosphere and providing a hands-on experience through augmented and virtual reality technologies. Design methods include literature studies, site surveys, and distributing questionnaires to ensure designs that suit visitor needs. This museum will be located in Medan City, North Sumatra, with facilities including an exhibition area, interactive space and souvenir area. This initiative aims to strengthen public understanding of Ulos and support global recognition as a cultural heritage that must be preserved.