bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of large volume paracentesis performed just prior to transjugular intrahepatic portosystemic shunt on the anesthetic management during the procedure
Authors: Li Hanzhou , Sun Zhuo , Odo Nadine , Keshavamurthy Jayanth H. , Agarwal Shvetank
Published: April 2021

Background and Aims:

Patients often undergo paracentesis prior to a transjugular intrahepatic portosystemic shunt (TIPS) procedure to improve respiratory mechanics. However, the effect of large volume paracentesis (LVP) on intraoperative hemodynamics and anesthetic management when it is performed immediately before the TIPS procedure is not well documented.

Material and Methods:

This is a retrospective study in patients undergoing the TIPS procedure between 2004 and 2017. Patients were divided into two groups based on the volume of preoperative paracentesis, namely, small volume paracentesis (SVP), defined as paracentesis volume less than 5 L and LVP, defined as paracentesis volume of at least 5 L. Patients' demographics and perioperative information were collected through chart review. The Wilcoxon signed-rank test, student's t-test, and Fisher's exact test were used when appropriate. Uni- and multivariate linear regression analyses were used to determine the predictive value of paracentesis volume in relation to intraoperative hemodynamics and management of hypotension.

Results:

Of 49 patients, 19 (39%) received LVP and the remainder received SVP. Baseline demographics were comparable between groups as were intraoperative hypotension and volume of infused crystalloid and colloid. However, vasopressor use (P = 0.02) and packed red blood cell transfusion (P = 0.01) were significantly higher in the large volume group. Paracentesis volume was an independent predictor of the phenylephrine dose (P = 0.0004), and of crystalloid (P = 0.05) and colloid (P = 0.009) volume administered after adjusting for age, sex, body mass index, alcohol use, hemoglobin, and model for end-stage liver disease score.

Conclusion:

The anesthetic management of patients who undergo LVP just prior to a TIPS procedure may require larger doses of vasopressors and colloids to prevent intraoperative hemodynamic instability during the TIPS placement but may be as well tolerated as SVP.
High-volume, multilevel local anesthetics–Epinephrine infiltration in kyphoscoliosis surgery
Authors: Mazy Alaa , Serry Mohamed , Kassem Mohamed
Published: April 2021

Background and Aims:

Local anesthetic (LA) infiltration is one of the analgesic techniques employed during scoliosis correction surgery. However, its efficacy is controversial. In the present study for optimizing analgesia using the infiltration technique, we proposed two modifications; first is the preemptive use of high volume infiltration, second is applying three anatomical multilevel infiltrations involving the sensory, motor, and sympathetic innervations consecutively.

Material and Methods:

This prospective study involved 48 patients randomized into two groups. After general anesthesia (GA), the infiltration group (I) received bupivacaine 0.5% 2 mg/kg, lidocaine 5 mg/kg, and epinephrine 5 mcg/mL of the total volume (100 mL per 10 cm of the wound length) as a preemptive infiltration at three levels; subcutaneous, intramuscular, and the deep neural paravertebral levels, timed before skin incision, muscular dissection, and instrumentation consecutively. The control group (C) received normal saline in the same manner. Data were compared by Mann-Whitney, Chi-square, and t-test as suitable.

Results:

Intraoperatively, the LA infiltration reduced fentanyl, atracurium, isoflurane, nitroglycerine, and propofol consumption. Postoperatively, there was a 41% reduction in morphine consumption, longer time to the first analgesic request, lower VAS, early ambulation, and hospital discharge with high-patient satisfaction.

Conclusion:

The preemptive, high-volume, multilevel infiltration provided a significant intra and postoperative analgesia in scoliosis surgery.
Comparative evaluation of transsacrococcygeal and transcoccygeal approach of ganglion impar block for management of coccygodynia
Authors: Malhotra Naveen , Goyal Sudeep , Kumar Amit , Kanika  , Singla Vishal , Kundu Zile Singh
Published: April 2021

Background and Aims:

Coccygodynia or Coccydynia is pain in the area of coccyx and ganglion impar block is commonly used technique for treatment of coccygodynia.

Material and Methods:

Forty patients of either sex in the age group of 20-70 years suffering from coccygodynia, who failed to respond to six weeks of conservative treatment were enrolled in the study. All patients were subjected to detailed clinical history, examination in the Pain Management Centre (Pain Clinic) of our Institute and imaging studies were reviewed. The patients were randomly divided into two groups of 20 each by a computer generated randomization number table: Group-TS (n = 20): Patients were administered ganglion Impar block by trans-sacrococcygeal approach Group-TC (n = 20): Patients were administered ganglion Impar block by trans-coccygeal approach with 8 ml of 0.5% bupivacaine plus 2 ml of 40mg/ml methylprednisolone acetate under fluoroscopic guidance.

Results:

Both the techniques of ganglion Impar block were effective and provided good pain relief to the patients with coccygodynia. There was a statistically and clinically significant improvement in pain score after ganglion Impar block in both the groups at all time intervals during the study period. (p < 0.05). The mean pain score after ganglion Impar block was <2 at all time intervals throughout the three month study period in all patients in the two groups. All patients in both the groups had excellent satisfaction immediately after ganglion Impar block. Five patients each in both groups required second ganglion Impar block during the three months study period.

Conclusion:

Both trans-sacrococcygeal and trans-coccygeal approaches of ganglion Impar block with a combination of local anaesthetic and steroid are safe and effective for management of coccygodynia. Trans-coccygeal ganglion Impar block through the first intra-coccygeal joint is better in terms of improvement in pain score, functional disability, patient satisfaction and ease of administration.
Airway management using LMA-evaluation of three insertional techniques-a prospective randomised study
Authors: Shyam T. , Selvaraj Venkatesh
Published: April 2021

Background and Aims:

Laryngeal Mask Airway [LMA] insertion has become as a basic procedural skill needed for all health care providers. Search for the most successful insertion technique continues. We evaluated the success rate of the three LMA insertion techniques- standard, 90 degree rotational and 180 degree rotational technique.

Material and Methods:

A total of 180 patients of ASA I-II aged 18-65 years undergoing open superficial surgical procedures with (LMA® Unique™ Airway, Teleflex®, Teleflex Medical Europe Ltd, Ireland) as an airway management device and with neuromuscular blocking agents, were randomly allocated to three groups, in this prospective randomized study. In the standard technique group (n = 60), the LMA was inserted by standard digital intraoral method. In the 90 degree rotational technique group (n = 60), the LMA was rotated counter-clockwise through 90 degree in the mouth and advanced until the resistance of the hypopharynx was felt, and then straightened out in the hypopharynx. In 180 degree rotational technique, LMA was inserted back-to-front, like a Guedel airway. The parameters studied were: the LMA placement success at first attempt, insertion time, need for more than one attempt at insertion, need for external airway manipulations, postoperative sore throat, blood staining and other post-operative (airway related) complications.

Results:

The first attempt success rate in the standard technique was 83.9%, in 90 degree rotational technique was 75% and 180 degree rotational was 93.5%. The first attempt success rate was higher in 180 degree rotational group compared to 90 degree rotational group (P < 0.05), but there was no statistically significant difference (P > 0.05) between 90 degree rotational group and the standard technique group. There was no statistically significant difference among the two groups in terms of the secondary outcomes.

Conclusion:

We conclude that 180 degree rotational technique of LMA insertion is more successful than 90 degree rotational technique in adult patients under general anaesthesia.
COVID-19 pandemic and its impact on peer review speed of anesthesiology journals
Authors: Behera Bikram Kishore , Radhakrishnan Rakesh Vadakkethil , Mohanty Chitta Ranjan , Bellapukonda Snigdha
Published: April 2021

Background and Aims:

Publication of a scientific article in a reputed journal is an uphill task that demands a significant amount of time and effort from the author and editorial team. It is a matter of great enthusiasm for all prospective researchers to know whether this daily evolving publication load of articles during this pandemic had changed the journal's inherent peer review or publication process. We aimed to compare the peer review speed of anesthesiology journal articles published during pandemic (2020) to the previous year and to analyze various factors affecting peer review speed.

Material and Methods:

Overall, 16 anesthesiology journals indexed in MEDLINE database were retrospectively analyzed. A set of 24 articles published in 2019 of the included journals were selected from each journal for control and a set of 12 articles published between January to September 2020 was selected for comparison. Time taken for acceptance and publication from the time of submission was noted. Peer review timing was calculated and its relationship with h-index, continent of journal origin and article processing charges were evaluated.

Results:

The median peer review time in 2019 and 2020 were 116 (108-125) days and 79 (65-105.5) days, respectively. There was a 31.8% decrease (P = 0.0021) in peer review time of all articles in 2020 compared to 2019. The median peer review timings of COVID-19 articles were 35 (22-42.5) days. A 55.6% decrease was noted in peer review time of COVID-19 articles compared to non-COVID-19 articles in 2020. There was a significant correlation between peer review time and h-index (r = 0.558, P = 0.024). There was no significant difference in peer review timing of journals with or without article processing charge (P = 0.75) and between journals from different continents (P = 0.56).

Conclusion:

Anesthesiology journals managed to curtail their turnaround time for peer review during the pandemic compared to previous year. Journal with higher h-index had longer peer review time. The option for articles processing charge and continent of publishing journal had no impact on peer review speed.
Evolution of videolaryngoscopy in pediatric population
Authors: Gupta Anju , Sharma Ridhima , Gupta Nishkarsh
Published: April 2021

Direct laryngoscopy has remained the sole method for securing airway ever since the inception of endotracheal intubation. The recent introduction of video-laryngoscopes has brought a paradigm shift in the pratice of airway management. It is claimed that they improve the glottic view and first pass success rates in adult population. The airway management in children is more challenging than adults. The role of videolaryngoscopy for routine intubation in children is not clearly proven. This review attempts to discuss various videolaryngosocpes available for use in pediatric patients.
Postintravenous Immunoglobulins Posterior Reversible Encephalopathy Syndrome in a Patient with Miller Fisher Variant of Guillain–barre Syndrome
Authors: Alamami Ans , Tawel Rabee , Zahra Farah , Abelaty Mohamed
Published: April 2021

Guillain–Barre syndrome (GBS) is an autoimmune disorder of the peripheral nerves manifested as inflammatory polyneuropathy of acute onset. The posterior reversible encephalopathy syndrome (PRES) is composed of gradual-onset neurological characteristics with unique radiological distribution (at the posterior brain region). Several etiologies, including hypertension, renal insufficiency, autoimmune diseases, medication use, and immunodeficiency, immunotherapy with intravenous immunoglobulin (IVIG) for various immune-related conditions, were associated with renal impairment, thrombotic manifestation, and reported PRES occurrence. Herein, we report a 73-year-old male who developed a clinical manifestation of PRES on top of IVIG therapy for Miller Fisher variant of GBS; therefore, PRES to be considered in a patient with GBS who treated with IVIG and developed alteration in the state of consciousness.
Steroid-Responsive Encephalopathy Associated with Thyroiditis
Authors: Shahzad Aamir , Iqbal Phool , Jamshaid Muhammad Bilal , Malik Rubab Fatima , Tayyeb Muhammad , Zafar Abdulaziz
Published: April 2021

steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) is an autoimmune entity with a strong association with elevated antithyroid antibodies. It is a rare cause of encephalopathy and is usually a diagnosis of exclusion. Responsive to corticosteroids is required to make the diagnosis. Herein, we report a male patient presented with recurrent convulsive episodes not controlled well by anticonvulsant drugs and had drops in Glasgow coma scale (GCS). After unremarkable of extensive investigations, Hashimoto's encephalitis was suspected and antithyroid peroxidase antibodies test turned out to be positive, while thyroid function tests were normal and the diagnosis of steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT) was made. He received a course of intravenous methylprednisolone for 5 days and responded very well to therapy, with an improvement of his GCS to 15/15.
Therapeutic Response of Patients with Progressive Macular Hypomelanosis to Narrowband Ultraviolet B Phototherapy at Dermatology Department, Tripoli Central Hospital, Tripoli, Libya (2008–2018)
Authors: El-Megei Halima Arebi , El-Houni Nadia Omar , Ezeddin Somaia Saleh
Published: April 2021

Background/Aim:

Progressive macular hypomelanosis (PMH) is a common skin disorder, predominantly affected young adults, especially women. The aim of the study was to evaluate the therapeutic response of this skin disease to narrowband ultraviolet B (UVB) phototherapy.

Methods:

A case series study of a total of 100 patients with PMH who were treated in the Phototherapy Unit at Tripoli Central Hospital in the period between January 2008 and December 2018.

Results:

Out of 100 patients, 82% were female and 18% were male with the mean age of 24.45 ± 4 years. NB-UVB therapy was given three times a week starting with 0.2 J/cm2, with 20% dose increment every session. The maximum cumulative dose was 65.13 J/cm2 with a mean cumulative dose of 20.48 ± 15 J/cm2. The maximum number of sessions was 36 sessions. A satisfactory response was achieved without any complications in most of the patients (89%) after a mean of 17.21 ± 7.2 treatments.

Conclusion:

PMH occurs mainly in adolescence and young adults with female predominance mainly with skin types IV and V. NB-UVB phototherapy seems to be effective, well-tolerated, safe, and easily administered treatment for progressive PMH.
Placing the results of the SOLIDARITY trial with regards to remdesivir in perspective
Authors: Bose Debdipta , Gogtay Nithya Jaideep , Rajan Sujeet K
Published: April 2021

Remdesivir, a repurposed antiviral, was first accorded approval by the US Food Drug Administration (FDA) for the treatment of COVID-19 which necessitates hospitalization. However, the interim data of SOLIDARITY trial revealed no benefits with remdesivir for COVID-19 patients which led immediate debates in social media and the press about the utility of the drug. Both preclinical and clinical data demonstrated its efficacy in COVID-19. The recently concluded ACTT-1 trial showed its efficacy in reducing the duration of hospital stay which is of utmost importance for a country like India where reduction in bed occupancy can save lives of many and eases the financial burden of patient and government. Our benefit-risk analysis of ACTT-1 trial also favored the use of remdesivir over standard of care. The SOLIDARITY trial was fundamentally different from other clinical trials on remdesivir with respect to its design, adaptive nature, and selection of endpoints. Moreover, the success of antiviral therapy also depends on the timing of initiation and combination with other drugs. Hence we believe that drugs like Remdesivir are very important for countries like India where soft end points such as time to recovery and clinical improvement and early discharge become extremely significant during a pandemic.
Dupilumab reduces systemic corticosteroid use and sinonasal surgery rate in CRSwNP
Authors: Desrosiers M. , Mannent L.P. , Amin N. , Canonica G.W. , Hellings P.W. , Gevaert P. , Mullol J. , Lee S.E. , Fujieda S. , Han J.K. , Hopkins C. , Fokkens W. , Jankowski R. , Cho S.H. , Mao X. , Zhang M. , Rice M.S. , Khan A.H. , Kamat S. , Patel N. , Graham N.M.H. , Ruddy M. , Bachert C.
Published: April 2021

BACKGROUND: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a type 2 inflammatory disease with a high symptom burden and poor quality of life. Treatment options include recurrent surgeries and/or frequent systemic corticosteroids (SCS). Dupilumab, a fully human monoclonal antibody, blocks the shared receptor component for interleukin-4 and interleukin-13, key drivers of type 2-mediated inflammation. We report results of pooled analyses from 2 randomised, double-blind, placebo-controlled phase 3 studies (SINUS 24 [NCT02912468]; SINUS-52 [NCT02898454]) to evaluate dupilumab effect versus placebo in adults with CRSwNP with/without SCS use and sinonasal surgery. METHODOLOGY: SINUS-24 patients were randomised 1:1 to subcutaneous dupilumab 300 mg (n=143) or placebo (n=133) every 2 weeks (q2w) for 24 weeks. SINUS-52 patients were randomised 1:1:1 to 52 weeks of subcutaneous dupilumab 300 mg q2w (n=150), 24 weeks q2w followed by 28 weeks of dupilumab 300 mg every 4 weeks (n=145) or 52 weeks of placebo q2w (n=153). RESULTS: Dupilumab reduced the number of patients undergoing sinonasal surgery (82.6%), the need for in-study SCS use (73.9%), and SCS courses (75.3%). Significant improvements were observed with dupilumab vs placebo regardless of prior sinonasal surgery or SCS use in nasal polyp, nasal congestion, Lund-MacKay, and Sinonasal Outcome Test (22-items) scores, and the University of Pennsylvania Smell Identification Test. CONCLUSIONS: Dupilumab demonstrated significant improvements in disease signs and symptoms and reduced the need for sino-nasal surgery and SCS use versus placebo in patients with severe CRSwNP, regardless of SCS use in the previous 2 years, or prior sinonasal surgery.
Vacunación y enfermedades reumáticas: una decisión compartida - Seguridad y eficacia
Authors: Fajardo Estefania , Caballero-Uribe Carlo V
Published: April 2021

La vacunación contra el covid-19 es la respuesta más importante que está dando la ciencia a la amenaza global que ha representado la pandemia. Este artículo especial de vacunación y enfermedades reumáticas tiene dos partes. En la primera parte se revisarán los aspectos relevantes de la seguridad y eficacia de las vacunas y en la segunda parte las consideraciones especiales en pacientes con enfermedades reumáticas autoinmunes teniendo en cuenta la necesidad de tener pacientes y médicos informados para la toma de decisiones compartidas. Estos artículos especiales surgen como respuesta al compromiso de PANLAR*, su consejo directivo y de Global Rheumatology en mantener a nuestros miembros y a la comunidad al tanto de las eventualidades más recientes con relación al covid-19 con la idea de poder contribuir a la toma de decisiones médico-paciente.
MAHMUDHOJA BEHBUDI IS A FIGURE OF HISTORY
Authors: Ulug‘ov Abdulla
Published: April 2021

Маҳмудхўжа Беҳбудий ўз ҳаётини эл-юрт равнақига бағишлаган шахс сифатида ўзбек халқи тарихида алоҳида ўрин тутади. ХХ аср ўзбек халқи тарихини унинг жўшқин ижтимоий-сиёсий, адабий-маърифий фаолиятисиз тасаввур этиб бўлмайди. У даврнинг ижтимоий-сиёсий ҳаракатларида фаол қатнашган, сиёсий арбоб, фидойи маърифатпарвар, янги ўзбек адабиёти асосчиларидан бири, янги мактаб, театр асосчиси, нашриёт, газета, журнал ташкилотчиси сифатида шуҳрат қозонган, адабий-бадиий, публицистик асарларида замоннинг ижтимоий-сиёсий, маънавий-маърифий муаммоларини биринчилардан бўлиб кўтариб чиққан.Мазкур мақолада Маҳмудхўжа Беҳбудийнинг “Падаркуш” драмаси ва айрим мақолаларининг ижтимоий аҳамияти тўғрисида мулоҳаза билдирилган.
Minimize Risk of Intra-Hospital Acquired Transmission to Confront Pandemic COVID-19 in Taiwan
Authors: Tan Ting Wan , Tan Han Ling , Chang Man Na , Lin Wen Shu , Chang Chih Ming
Published: April 2021

Since December 2019, the COVID-19 confirmed case number has increased rapidly in China. Subsequently has spread globally. Since late January 2020, Taiwan CDC and government have took measures early and quick response to Covid-19, take action to develop strategies to manage epidemic crisis and community spread in early stage. Taiwan has aware importance of design of isolation route from emergency department, outpatient, intensive care unit, ordinary ward and isolation rooms in health care facilities. For yearly hospital evaluation has been assessed elements that related functional capacity of hospital safety, which aims to examine the level of preparedness of hospital staffs for major emergencies or disaster.
PERSEPSI KEPUASAN KONSUMEN TERHADAP KUALITAS PELAYANAN DI GREEN WHITE CAFÉ BOGOR
Authors: Osta Nababan Benny , Fakhri Ramadhan Muhammad
Published: April 2021

Penelitian ini bertujuan untuk mengetahui tingkat kepuasan konsumen terhadap kualitas pelayanan di Green White Café Bogor, kemudian untuk mengetahui nilai indeks kepuasan konsumen di Green White Café Bogor saat ini dan yang terakhir adalah untuk mengetahui faktor yang harus diperbaiki agar kepuasan konsumen dapat terpenuhi. Populasi dalam penelitian adalah pengunjung Green White Café Bogor dengan jumlah sampel sebanyak 100 responden dan ditentukan berdasarkan rumus Slovin. Teknik pengumpulan data dilakukan menggunakan survey dan kuesioner, sedangkan untuk analisis data menggunakan bantuan Software Microsoft Excel 2010 dan SPSS versi 22 untuk menguji yaitu uji validitas, uji reliabillitas, Service Quality (SQ), Customer Satisfaction Index (CSI) dan Importance Performance Analysis (IPA). Hasil penelitian menunjukan bahwa terdapat 12 kualitas layanan yang mendapat gap negatif, 4 kualitas layanan yang mendapat gap positif, dan 1 yang tidak terdapat gap. Kemudian untuk nilai indeks kepuasan konsumen di Green White Café Bogor saat ini didapati sebesar 83,27% yang berarti konsumen merasa cukup puas namun dirasa belum maksimal secara keseluruhan, dan pada analisis importance performance analysis (IPA), terdapat satu atribut pelayanan yang harus menjadi prioritas utama untuk diperbaiki oleh manajemen café agar dapat memenuhi kepuasan konsumen.
PERSEPSI KEPUASAN MASYARAKAT TERHADAP KUALITAS PELAYANAN PUBLIK DI SISTEM ADMINISTRASI MANUNGGAL SATU ATAP KABUPATEN BOGOR
Authors: Andayani Asti , Ichrisa Pujiyanti Nur
Published: April 2021

ABSTRAK

Penelitian ini bertujuan untuk mengetahui dan menganalisis tingkat kinerja pelayanan SAMSAT Kabupaten Bogor terhadap kepuasan masyarakat, kemudian mengetahui tingkat harapan pelayanan SAMSAT Kabupaten Bogor berdasarkan pendapat masyarakat, dan yang terakhir adalahh mengetahui tingkat kesenjangan antara kinerja dan harapan terhadap pelayanan SAMSAT Kabupaten Bogor. Populasi dalam penelitian adalah para wajib pajak di SAMSAT Kabupaten Bogor dengan jumlah sempel sebanyak 100 responden. Teknik pengumpulan data dilakukan menggunakan survey dan kuesioner, sedangkan untuk analisis data menggunakan bantuan Software Microsoft Excel 2007 dan SPSS versi 22 untuk menguji yaitu, uji validitas, uji reliabilitas, Service Quality (SQ), Customers Satisfaction Index (CSI), dan Importance Performance Analysis (IPA).Hasil Penelitian menunjukan nilai indeks kepuasan masyarakat terhadap kualitas pelayanan di SAMSAT Kabupaten Bogor saat ini sebesar 81,50% yang berarti konsumen cukup puas dengan pelayanan di Kabupaten Bogor namun dirasa belum maksimal secara keseluruhan, adapun harapan yang terpenting bagi masyarakat ada pada kebersihan dan keamanan lingkungan sementara yang rendah ada pada kedisiplinan petugas sehingga ketiga faktor itu harus ditingkatkan serta diperbaiki, dan terakhir pada seluruh indikator kualitas pelayanan mendapatkan gap negatif.
Long non-coding RNA PVT1 regulates the proliferation
and metastasis of human breast cancer via the
Wnt/b-catenin signalling pathway
Authors: Zhang Nianqu , Li Qing , Sun Shanmei
Published: April 2021

Introduction

The development of many human diseases has been implicated to be coupled by the dysregulation of long non-coding RNAs (lncRNAs).
Considering this, the current study was aimed at identifying and then investigating the molecular role of a specific lncRNA from a set of such genetic
elements in regulating the developmental aspects of human breast cancer.

Material and methods

The quantitative real-time polymerase chain reaction
(qRT-PCR) method was used to deduce the gene expression levels. Proliferation of cancer cells was determined by the cell counting kit 8 (CCK8). The
evaluation of apoptotic cell death in breast cancer cells was made through
the acridine orange/ethidium bromide (AO/EB) and annexin V-FITC staining
protocols. Transwell assays were used to monitor cell migration and invasion.

Results

Estimation of gene expression levels of a set of lncRNAs showed
that lncRNA PVT1 is specifically overexpressed in the breast cancer tissues
and cell lines. The downregulation of PVT1 in cancer cells negatively affected
their proliferation rates, and cancer cells exhibited significantly lower viabilities due to induction of Bax/Bcl-2 signal arbitrated apoptotic cell death in
the cancer cells. Moreover, the cancer cells showed significantly lower rates
of migration and invasion when lncRNA PVT1 was repressed. The PVT1 repression-driven anti-cancer effects against the cancer cells were seen to be
modulated through the Wnt/β-catenin signalling pathway.

Conclusions

The results of this work are indicative of the prognostic role of
lncRNA PVT1 in breast cancer. Also, the molecular targeting of PVT1 might
prove to be a vital step against the progression of human breast cancer.
Prediction of Prognosis and Survival of Patients with Gastric Cancer by Weighted Improved Random Forest Model
Authors: Xu Cheng , Wang Jing , Zheng TianLong , Cao Yue , Ye Fan
Published: April 2021

Introduction

It’s very necessary to predict the survival status of patients based on their prognosis. This can assist physicians in evaluating treatment decisions. Random Forest is an excellent machine learning algorithm even without any modification. We propose a new Random Forest weighting method and apply it to the gastric cancer patient data from the Surveillance, Epidemiology, and End Results (SEER) program, and then evaluated the generalization ability of this weighted Random Forest algorithm on 10 public medical datasets. Furthermore, for the same weighting mode, the difference between using out-of-bag (OOB) data and all training sets as the weighting basis is explored.

Material and methods

110697 cases of gastric cancer patients diagnosed between 1975 and 2016 obtained from the SEER database were contained in the experiment. In addition, 10 public medical datasets are used for the generalization ability evaluation of this weighted Random Forest algorithm.

Results

Through experimental verification, on the SEER gastric cancer patient data, the weighted Random Forest algorithm improves the accuracy by 0.79% compared with the original Random Forest. In AUC, Macro-averaging increased by 2.32% and Micro-averaging increased by 0.51% on average. Among the 10 public datasets, the Random Forest weighted in accuracy has the best performance on 6 datasets, with an average increase of 1.44% in accuracy and an average increase of 1.2% in AUC.

Conclusions

Compared with the original Random Forest, the weighted Random Forest model has a significant improvement in performance, and the effect of using all training data as the weighting basis is better than using OOB data.
Um retrato da pandemia em preto e branco – um estudo sobre a mortalidade por COVID-19 entre brancos e negros no Brasil
Authors: Santos Edy Lawson Silva , Taufick Jairo
Published: April 2021

O acometimento mundial pela doença pandêmica COVID-19, declarada como tal em 30 de janeiro de 2020, é a força motriz dessa pesquisa. A COVID-19 se manifestou em quase a totalidade dos países do mundo, mas a sua evolução e características de contaminação foram, e ainda são, diferentes em cada nação. O lócus desse trabalho é o Brasil, um país historicamente forjado sobre significativas segregações sociais, raciais e econômicas. Com um histórico de ausência do estado em termos de políticas públicas, a população negra foi alocada estruturalmente na base da sociedade brasileira. É nesse diapasão que se insere a pergunta problema dessa pesquisa: a população negra é mais suscetível ao evento morte, pela pandemia da COVID-19, que a população branca? Foram utilizados os dados secundários que registram os casos de Síndrome Respiratória Grave (SRAG) do Ministério da Saúde do Brasil, extraídos da plataforma eletrônica “Open Data SUS”. Para a análise multivariada dos dados foi empregada a técnica estatística da regressão logística. A partir de diversos modelos com a inclusão de variáveis explicativas, os resultados evidenciam que as pessoas negras são mais vulneráveis e têm 77,36% mais chances de morrer pela COVID-19 que as pessoas brancas.
Remediating abnormal oral cavity motor strategies in a horn player using RT-MRI: a case study
Authors:   Utah Valley University, Douglass Natalie , Iitis Peter ,   Gordon College, Frahm Jens ,   Max-Planck Institute for Biophysical Chemistry, Voit Dirk , Joseph Arun , Fisher Patricia
Published: April 2021

This study uses real-time (cine) MRI to examine how orofacial myofunctional disorders (OMDs) affect muscle function during speech and horn playing. Dynamic MRI images were captured of an OMD subject and control subjects reciting a speech task and sustaining a note on an MRI-compatible horn. A following visual feedback session allowed the OMD subject to view and react to their (cine) MRI next to the image of an elite subject. Profile lines created in MATLAB allowed analysis of muscle function and changes in oral cavitation between the OMD and control subjects. In both the speech and horn films, the OMD subject consistently utilized maladaptive muscle movements, resulting in low and forward tongue position against the front teeth. Both control subjects had tongue placement free of the front teeth, and the horn control subject could elevate the tongue to narrow the air stream and play higher pitches. The MRI films suggest a connection between speech disorders and compromised horn-playing technique. OMDs limit the ability of the tongue to make the changes in oral cavitation used to play different pitches on the horn.
Indications and complications of thyroidectomy in Al-Ramadi teaching hospital
Authors: Saleh Esmael , Fakhree Aamer , Al-Ani Raid M.
Published: April 2021

Thyroidectomy is one of the common operations performed worldwide. It is a main option of treatment for different benign and malignant thyroid problems. Despite improvements in procedures have decreased mortality and even and morbidity rates to a minimum; however, postoperative complications remain a major concern among surgeons. We aimed to evaluate the indications and complications of thyroidectomy. A Prospective study was conducted at Al-Ramadi Teaching Hospital/Ramadi city/Iraq during the period from January 2009 to January 2010. There were 130 patients underwent thyroidectomy. A demographic and clinical data for each patient was recorded to assess indications and complications of different types of thyroidectomies. The majority of the patients were females (93{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). The most age group affected was 21-30 years (41.54{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). Pressure symptoms were accounting for 61.54{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} of the indications. Thyroid enlargement in euthyroid states (80{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) was the common presenting state. Subtotal thyroidectomy (58.46{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) was the commonest procedure. Out of 130 patients, 36 patients (27.69{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) were suffered from complications. The 2 most common complications encountered in the study were hypocalcemia (61.11{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) and recurrent laryngeal nerve palsy (5.38{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). In conclusion, subtotal thyroidectomy is a common procedure in our hospital. Compressive complaints were the most common indication. Hypocalcemia and recurrent laryngeal nerve palsy were the 2 most postoperative complications.
ANALISIS REAKSI PASAR MODAL TERHADAP PERISTIWA PEMILIHAN UMUM PRESIDEN REPUBLIK INDONESIA PADA TANGGAL 17 APRIL 2019 (STUDI PERISTIWA PADA KELOMPOK SAHAM LQ45 PERIODE APRIL 2019)
Authors: Safitri Puji Lestari  , Yunita Irni
Published: April 2021

Penelitian ini bertujuan untuk mengetahui perbedaan abnormal return sebelum dan sesudah peristiwa Pemilihan Umum Presiden Republik Indonesia pada tanggal 17 April 2019 pada Bursa Efek Indonesia dan volume perdagangan saham yang dapat diukur menggunakan trading volume activity. Populasi penelitian adalah seluruh perusahaan yang masuk ke perusahaan LQ45 di BEI pada periode Februari – Juli 2019 sebanyak 45 perusahaan. Pengambilan sampel dalam penelitian ini dilakukan dengan metode purposive sampling, artinya jumlah sampel yang diambil adalah sampel yang sesuai dengan kriteria, yaitu sebanyak 45 perusahaan. Penelitian ini menggunakan jenis penelitian studi peristiwa yang digunakan untuk mempelajari reaksi pasar suatu peristiwa yang informasinya dipublikasikan suatu pengumuman. Penelitian ini menggunakan metode kuantitatif, menggunakan data sekunder yang diperoleh melalui teknik pengumpulan data pada dokumen. Untuk menguji hipotesis penelitian ini menggunakan uji Wilcoxon test. Hasil uji hipotesis menggunakan Wilcoxon test pada abnormal return tidak memiliki pengaruh yang signifikan sebelum dan sesudah peristiwa Pemilihan Umum Presiden Republik Indonesia 17 April 2019 dengan nilai signifikansi sebesar 0,835 lebih besar dari 0,05. Sedangakan, hasil uji hipotesis menggunakan Wilcoxon test pada trading volume activity memiliki pengaruh yang signifikan sebelum dan sesudah peristiwa Pemilihan Umum Presiden Republik Indonesia 17 April 2019 dengan nilai signifikansi sebesar 0,003 lebih kecil dari 0,05.
Application of 25-National Eye Institute Visual Function Questionnaire in ophthalmological patients
Authors: Simmo Luciano Mesquite , Ibrahim Carissa Fouad , Silva Senice Alvarenga Rodrigues , Andrade Thai Nunes , Leite Doora Faleiros , Arajo Roberto Ferreira de Almeida
Published: April 2021

Objective: To compare the vision-targeted health related quality of life (HRQOL) between neuro-ophthalmological patients and other eye diseases by the National Eye Institute 25-Item Visual Function Questionnaire. Methods: Cross sectional study with a control group and patients with the following pathologies: primary open-angle glaucoma (POAG), diabetic retinopathy (DR), age-related macular degeneration (ARMD), non-arteritic ischemic optic neuropathy (NAION), intracranial hypertension (IH), optic neuritis (ON), ptosis and cataract. Results: All comparisons of the subscales scores among the control group and the patient groups were statistically significant (p<0.05) except for “ocular pain” (p=0.160), “social functioning” (p=0.052) and “peripheral vision” (p=0.112). The control group had the best scores across all dimensions of the NEI VFQ-25. Interestingly, the ARMD and cataract groups presented the best and worst total scores of NEI VFQ-25, respectively. The lowest subscales scores were found in the cataract, in the NAION/ON, and in the POAG groups. Finally, the comparison between the NAION/ON/IH patients and the other eye diseases did not show statistical significance in any subscale. Conclusion: The NEI VFQ-25 showed the impact of various eye conditions in vision-targeted HRQOL, and no difference was measured between neuro-ophthalmological patients and other eye diseases
ORGANIZATIONAL AND PEDAGOGICAL CONDITIONS FOR FORMING ENTREPRENEURIAL CAPABILITIES IN FUTURE TEACHERS
Authors: Ualieva N. T. , Murzalinov A. Zh. , Almagambetova L. S.
Published: April 2021

The article demonstrates the need for the formation of entrepreneurial abilities in future teachers, in view of the development of the educational entrepreneurship environment under the influence of the global economy. At the same time, the problems of insufficient methodological substantiation of educational entrepreneurship, undeveloped psychological and pedagogical support for the formation of entrepreneurial abilities in future teachers, organization of the educational process in pedagogical universities, excluding the action of market mechanisms are identified . To solve the problems, the objective of the study is determined, which is related to the organizational and pedagogical conditions for the development of entrepreneurial abilities in future teachers. These conditions are implemented in experimental work as a part of the developed model at the M. Kozybaev North Kazakhstan University. According to the results of the experimental work, it has been confirmed that, modeling the environment of educational entrepreneurship, organizational and pedagogical conditions motivate future teachers to educational and entrepreneurial activities, professionally enrich the educational environment of the university, lay the groundwork for self-realization in professional and pedagogical activities.
TO THE QUESTION ABOUT THE PROBLEMS OF MANAGEMENT OF FUNCTIONING OF THE REGIONAL INNOVATION INFRASTRUCTURE IN THE CONTEXT OF DIGITALIZATION OF THE ECONOMY ON THE EXAMPLE OF THE VOLOGDA REGION
Authors: Sakhanevich D. Yu.
Published: April 2021

The elements of the socio-economic system function in the dynamics that correspond to the periods of rise and fall in the efficiency of activity. Recessions are characterized by problems (obstacles), which are also found in the functioning of the innovation infrastructure as one of the elements of the system. The article systematizes the problems of the functioning of the innovation infrastructure to accelerate the recovery from the downturn. The goal was achieved through the analysis of management systems and regulation of innovation infrastructure by studying strategic planning documents, the effectiveness of their implementation in practice and identifying their compliance with reality in the context of ongoing digitalization.
Civic agriculture in review: Then, now, and future directions
Authors: Kaika Allison , Racelis Alexis
Published: April 2021

“Civic agriculture,” a term first coined by rural sociologist Thomas Lyson, refers to forms of agriculture that occur on a local level, from production to consumption, and are linked to a community’s social and economic development. Sixteen years since its original articulation, the term “civic agriculture” has taken on greater significance in research, political activism, and community organizing. Grown from the roots of civic community theory, civic agriculture functions as a new branch of civic community theory that is ripe for theorization. In revisiting the foundations of the term, this review paper seeks to consolidate current and future research in the field of civic agriculture with a focus on its link to social welfare. This begins by reviewing the foundations of civic community theory and discussing how they influence research related to civic agriculture. As we report in this paper, there remain considerable gaps in understanding of how civic agriculture can be fomented by—or is related to—indicators such as demographics, concentration of power, community cohesion, and civic engagement. Consequently, the assumed links between local food systems and social welfare must continue to be studied to determine correlation and causality. This understanding is particularly important during this time of global pandemic, when the flaws and inequities of global supply chains are exposed and where, in many cases, civic agriculture met the increasing interest in local food. The COVID-19 pandemic has amply demonstrated the fragility and instability of global food supply chains, making the need for local food systems more significant and more relevant to communities across the world.
Marketing of Cities as Centres of Socio-Economic Development in the Process of Globalisation
Authors: Ignatyevs Sergeys , Makushkin Sergey A. , Spivakovskyy Sergiy
Published: April 2021

Modern trends in the formation of urban development are based primarily on the extent to which the territory of a city can be attractive for investors, interested people in general and public administration systems. When regarding programs for the development of urban areas in the structure of sustainable development, it is necessary to highlight the methods of forming an attractive image of a city, which is considered a marketing tool. Understanding the possibilities for the development of an urban area requires the formation of tools for spatial marketing and opportunities for the establishment of measures for the development of individual tools of communication between city authorities and the external environment. The novelty of the research is determined by the structural feature of the formation of an integrated method of using marketing tools to promote the image of a city in the informational, social, and cultural aspects. The authors show the tools for implementing the marketing strategy of the urban area as elements of sustainable development. Stakeholders of sustainable development are shown not only local management structures but also global investment funds and transnational corporations. The practical significance of the study is determined by the possibility of forming based on an urban area, which is marked by the presence of sustainable development markers, innovative and science-intensive centres, and analytical corporations. The formation of development centres is also possible through the creation of smart cities.
The Student Relationship Management System Process with Intelligent Conversational Agent Platform
Authors: Phuengrod Siriluk , Wannapiroon Panita , Nilsook Prachyanun
Published: April 2021

The objectives of the study were as follows: (1) to study the student relationship management system process with intelligent conversational agent platform, (2) to design the student relationship management system process with intelligent conversational agent platform, and (3) to evaluate the student relationship management system process with intelligent conversational agent platform provided by seven experts who had experience in a related field. The study findings suggested that the student relationship management system process with intelligent conversational agent platform consists of four main dimensions: (1) Strategic, (2) Operational, (3) Analytical, and (4) Collaborative. After analyzing the data, it showed that the overall result of the evaluation of the student relationship management system process with intelligent conversational agent platform was at a very high appropriate level, which can be applied to real situations.
Using the Financial Analysis Approach to Forecast Industrial Production: A Guide from Jordan
Authors: Banikhalid H. , Al-oshaibat S.
Published: April 2021

This study aims to derive the function that can be used to predict the growth rate in the added value of industrial production in Jordan, depending on the financial ratios of industrial companies listed on the Amman Stock Exchange. To achieve the objectives of the study, the descriptive and analytical approach and multiple regression analysis were used using the SPSS program. The study population was represented by the public joint-stock companies listed on the Amman Stock Exchange in the industrial sector from 1994 to 2018. Results show that the financial ratios influencing the growth rate in industrial production value added the most (Industry t + 1) are earnings per share (EPS), net profit margin (NPM), and return on equity (ROE). Moreover, the effect is non-linear expressed by a function that can be used to predict the industrial production in Jordan. The study recommends paying attention to the partial input to predict macroeconomic variables, especially with the development of systems for storing and processing big data, as this method provides appropriate and sufficient data to make accurate decisions and enhances the right track.
«Dere skal være enige med meg også!» Elevers administrering av gruppesamtaler i en periode med eksplisitt samtaleundervisning i norskfaget
Authors: Kvistad Tone
Published: April 2021

I denne artikkelen undersøker jeg hvordan elever på 7. trinn administrerte gruppe­samtaler underveis i et ti uker langt undervisningsforløp med eksplisitt undervisning i samtaleferdigheter. Designet av norsktimene i denne perioden var inspirert av «Talk Lessons» fra Thinking Together-tilnærmingen (Dawes et al., 2004), som blant annet innebærer etablering av samtaleregler for å fremme utforskende gruppesamtale (eng. «exploratory talk»). Jeg analyserer samtaleadministrering i fire smågrupper ved hjelp av den konstant komparative metoden (Corbin & Strauss, 2015). Seks former for sam­taleadministrerende ytringer i materialet blir eksemplifisert og analysert med hensyn til hvilke funksjoner ytringene har i elevenes gruppesamtaler. Funnene indikerer at under­visningen stimulerte elevenes bevissthet om egen og andres samtaledeltakelse, selv om måten samtalene ble administrert på i flere tilfeller virket mekanisk. Dette tyder på at elevene var i ferd med å mestre nye kommunikative redskaper, men at disse enda ikke var fullt approprierte. Et annet funn er at gruppesamtalene var preget av et «enighets­trykk», der elevene ble opptatte av å komme raskt fram til felles svar. Dette enighets­trykket så ut til å være kontraproduktivt med tanke på at samtalereglene skulle stimulere til utforsking. Artikkelen er et bidrag til norskfagets muntlighetsdidaktikk ved at den belyser betydningen av eksplisitt samtaleundervisning. Samtidig leder også funnene til kritisk refleksjon rundt elementer ved undervisningstilnærmingen som ble prøvd ut.
Nøkkelord: muntlige ferdigheter, norskfaget, mellomtrinnet, utforskende samtale, samtaleregler