bluuebunny/crossref_metadata_2025 huggingface dataset:
Shell–Core Microbeads Loaded with Probiotics: Influence of Lipid Melting Point on Probiotic Activity
Authors: Xie Youfa , Zhang Kui , Zhu Jingyao , Ma Li , Zou Liqiang , Liu Wei
Published: July 2024

Probiotics have many beneficial physiological activities, but the poor stability during storage and gastrointestinal digestion limits their application. Therefore, in this study, a novel type of shell–core microbead for loading probiotics was prepared through high-precision concentric drop formation technology using gelatin as the shell material and lipids as the core material. The microbeads have a regular spherical structure, uniform size, low moisture content (<4%) and high probiotic activity (>9.0 log CFU/g). Textural testing showed that the hardness of the medium-chain triglyceride microbeads (MCTBs), cocoa butter replacer microbeads (CBRBs) and hydrogenated palm oil microbeads (HPOBs) increased gradually (319.65, 623.54, 711.41 g), but their springiness decreased (67.7, 43.3, 34.0%). Importantly, lipids with higher melting points contributed to the enhanced stability of probiotics during simulated digestion and storage. The viable probiotic counts of the HCTBs, CBRBs and HPOBs after being stored at 25 °C for 12 months were 8.01, 8.44, and 8.51 log CFU/g, respectively. In the simulated in vitro digestion process, the HPOBs resisted the destructive effects of digestive enzymes and gastric acid on probiotics, with a reduction in the probiotic viability of less than 1.5 log CFU/g. This study can provide new ideas for the preparation of intestinal delivery probiotic foods.
Cheese Whey Protein and Blueberry Juice Mixed Fermentation Enhance the Freeze-Resistance of Lactic Acid Bacteria in the Freeze-Drying Process
Authors: Wang Yuxian , Liu Xian , Shao Yufeng , Guo Yaozu , Gu Ruixia , Wang Wenqiong
Published: July 2024

The effects of MRS, whey protein and blueberry alone, and mixed fermentation on the survival rate of lactic acid bacteria under various freeze-drying conditions were investigated. The surface structure of the freeze-dried powders was also investigated to explore the anti-freezing protection mechanism of mixed whey protein and blueberry fermentation on the bacteria. It was found that the mixed fermentation medium of blueberry and whey protein has a protective effect on the freeze-drying bacteria and is better than the traditional MRS and whey protein medium. The optimal concentration of blueberry juice addition was 9%. The survival rate of the pre-freezing temperature at −80 °C was higher than at −20 °C after the pre-freezing and freeze-drying processes. The freeze-drying thickness of 0.3 cm could improve the survival rate of the bacteria. The Fourier transform infrared spectroscopy results indicated the interaction between the whey protein, anthocyanins, and the surface composition of the lactic acid bacteria.
Silk Fibroin-Enriched Bioink Promotes Cell Proliferation in 3D-Bioprinted Constructs
Authors: Lipari Sara , Sacco Pasquale , Marsich Eleonora , Donati Ivan
Published: July 2024

Three-dimensional (3D) bioprinting technology enables the controlled deposition of cells and biomaterials (i.e., bioink) to easily create complex 3D biological microenvironments. Silk fibroin (SF) has recently emerged as a compelling bioink component due to its advantageous mechanical and biological properties. This study reports on the development and optimization of a novel bioink for extrusion-based 3D bioprinting and compares different bioink formulations based on mixtures of alginate methacrylate (ALMA), gelatin and SF. The rheological parameters of the bioink were investigated to predict printability and stability, and the optimal concentration of SF was selected. The bioink containing a low amount of SF (0.002% w/V) was found to be the best formulation. Light-assisted gelation of ALMA was exploited to obtain the final hydrogel matrix. Rheological analyses showed that SF-enriched hydrogels exhibited greater elasticity than SF-free hydrogels and were more tolerant to temperature fluctuations. Finally, MG-63 cells were successfully bioprinted and their viability and proliferation over time were analyzed. The SF-enriched bioink represents an excellent biomaterial in terms of printability and allows high cell proliferation over a period of up to 3 weeks. These data confirm the possibility of using the selected formulation for the successful bioprinting of cells into extracellular matrix-like microenvironments.
Sol–Gel Synthesis of TiO2 with Pectin and Their Efficiency in Solar Cells Sensitized by Quantum Dots
Authors: Flores-Gómez Jean , Mota-Macías Silvia , Guerrero-Jiménez Juan P. , Romero-Arellano Victor Hugo , Morales-Rivera Juan
Published: July 2024

In this study, titanium oxide TiO2 nanoparticles were produced using the sol–gel approach of green synthesis with pectin as the reducing agent. The synthetized TiO2 nanoparticles with pectin were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), visible light absorption (UV–Vis) and the BET method. The structure and morphology of the TiO2 powder were described with SEM, revealing uniform monodisperse grains with a distribution of 80% regarding sizes < 250 nm; the resulting crystal phase of synthetized TiO2 was identified as an anatase and rutile phase with a crystallinity size estimated between 27 and 40 nm. Also, the surface area was determined by nitrogen adsorption–desorption using the Brown–Emmet–Teller method, with a surface area calculated as 19.56 m2/g, typical of an IV type isotherm, indicating mesoporous NPs. UV–Vis spectra showed that sol–gel synthesis reduced the band gap from the 3.2 eV common value to 2.22 eV after estimating the optical band gap energy using the adsorption coefficient; this translates to a possible extended photo response to the visible region, improving photoactivity. In addition, the power conversion of the photoelectrode was compared based on similar assembly techniques of TiO2 electrode deposition. Quantum dot crystals were deposited ionically on the electrode surface, as two different paste formulations based on a pectin emulsifier were studied for layer deposition. The results confirm that the TiO2 paste with TiO2-synthesized powder maintained good connections between the nanocrystalline mesoporous grains and the deposited layers, with an efficiency of 1.23% with the transparent paste and 2.27% with the opaque paste. These results suggest that pectin could be used as a low-cost, functional sol–gel catalysis agent for the synthesis of controlled NPs of metal oxide. It demonstrates interesting optical properties, such as an increase in photo response, suggesting further applications to photocatalysts and biomedical features.
Awareness and Willingness towards Organ Donation among Riyadh Residents: A Cross-Sectional Study
Authors: Alghalyini Baraa , Zaidi Abdul Rehman Zia , Faroog Zainudheen , Khan Mohammad Salman , Ambia Saad Rahman , Mahamud Golam , Tamim Hala
Published: July 2024

Background: The increasing prevalence of chronic diseases in Saudi Arabia has heightened the need for organ transplantation; however, the donor pool remains insufficient. This study explored awareness and willingness towards organ donation among Riyadh residents and examined the sociodemographic factors influencing these attitudes. Methods: A cross-sectional survey using convenience sampling was conducted among adults in Riyadh. The survey assessed demographic characteristics, awareness, willingness to donate, and sociodemographic factors. Statistical analyses included descriptive statistics and logistic regression. Results: Among the 645 respondents, 56.4% were willing to donate organs, with females showing a higher propensity than males (OR 2.9, 95% CI 1.7–5.1, p < 0.001). Awareness of organ donation centers was linked to increased willingness to donate (OR 1.5, 95% CI 1.1–2.5, p < 0.001). Higher educational level was strongly associated with donor registration (OR 36.8, 95% CI 14.7–91.9, p < 0.001). Despite their high willingness, only 9.5% were registered as donors, highlighting the gap between intention and action. Conclusions: Riyadh residents showed a significant willingness to donate organs, influenced by gender, education, and awareness. Low registration rates suggest barriers such as religious beliefs and lack of information. Targeted educational campaigns and policy evaluations, including an opt-out system, are recommended to enhance registration rates.
Insight into Current Practices of Community Pharmacists in Topical Corticosteroid Prescribing and Counseling: Cross-Sectional Survey Study from Saudi Arabia
Authors: Kurdi Sawsan M. , Alamer Ahmad , Alqarni Arjwan , AlQahtani Sara , AlKahlah Shahad , Alotaibi Fawaz M. , Asiri Ibrahim M. , Wali Haytham A.
Published: July 2024

Background: Topical corticosteroids are commonly used to treat several skin conditions, most notably atopic dermatitis. Many studies have found that patients lack knowledge about the safety, potency, and appropriate use of topical corticosteroids. This can be due to ineffective education by pharmacists and other healthcare providers. This study aims to evaluate the appropriateness of dispensing and counseling practices of community pharmacists towards topical corticosteroids in Saudi Arabia. Methods: A cross-sectional survey study was conducted in Saudi Arabia among 418 community pharmacists from different regions of Saudi Arabia. Data were collected using a validated questionnaire that covered community pharmacists’ sociodemographic information, their perceptions of patient knowledge about topical corticosteroid use, and their dispensing and their counseling practices, in addition to their perceived barriers to counseling. Results: The majority of the participating community pharmacists were Saudi (57.4%), female (66.7%), holding a bachelor’s degree (63.4%), and full-time workers (91.1%). Most of the time, community pharmacists counseled patients on the frequency of application per day and the duration of treatment (75.8% and 74.8%, respectively). The median counseling practice score was 17, with an IQR of 14–21. The main barrier to counseling was lack of time (33.7%). Only 15% of community pharmacists accurately identified all scenarios that necessitate medical referrals. Dry skin, itchiness, and irritation were the most common side effects reported by community pharmacists for patients to complain about (69.4%). Most pharmacists agreed that misuse is the most likely cause of topical corticosteroid adverse drug events (53.7%), followed by medication overuse, such as patient self-treatment (48%). Conclusion: Community pharmacists counseling practices to their patients about the use of topical corticosteroids require improvement. Continuing education and hands-on training are needed for community pharmacists regarding counseling about topical corticosteroids use.
The Effects of Motor Imagery on Static and Dynamic Balance and on the Fear of Re-Injury in Professional Football Players with Grade II Ankle Sprains
Authors: Plakoutsis George , Tsepis Elias , Fousekis Konstantinos , Paraskevopoulos Eleftherios , Papandreou Maria
Published: July 2024

Lateral ankle sprains are one of the most frequent athletic injuries in football, causing deficits in balance. Motor Imagery (MI) has been successively included in sports rehabilitation as a complementary therapeutic intervention. The aim of the present study was to explore the effects of MI on static and dynamic balance and on the fear of re-injury in professional football players with Grade II ankle sprains. Fifty-eight participants were randomly allocated into two groups: First—MI group (n = 29) and second—Placebo group (n = 29), and they each received six intervention sessions. The first MI group received MI guidance in addition to the balance training program, while the second Placebo group received only relaxation guidance. One-way ANOVA showed statistically significant results for all variables, both before and 4 weeks after the interventions for both groups. The t-test showed statistically significant differences between the two groups for static balance for the right lower extremity (t = 3.25, S (two-tailed) = 0.002, p < 0.05) and also for heart rate (final value) in all time phases. Further research is needed in order to establish MI interventions in sports trauma recovery using stronger MI treatments in combination with psychophysiological factors associated with sports rehabilitation.
Clinical Applications of Exosomes: A Critical Review
Authors: Lee Kar Wai Alvin , Chan Lisa Kwin Wah , Hung Lee Cheuk , Phoebe Lam Kar Wai , Park Youngjin , Yi Kyu-Ho
Published: July 2024

Exosomes, small membrane-bound vesicles secreted by cells, have gained significant attention for their therapeutic potential. Measuring 30–100 nm in diameter and derived from various cell types, exosomes play a crucial role in intercellular communication by transferring proteins, lipids, and RNA between cells. This review analyzes existing literature on the clinical applications of exosomes. We conducted a comprehensive search of peer-reviewed articles and clinical trial data to evaluate the benefits, limitations, and challenges of exosome-based therapies. Key areas of focus included regenerative medicine, cancer therapy, gene therapy, and diagnostic biomarkers. This review highlights the vast clinical applications of exosomes. In regenerative medicine, exosomes facilitate tissue repair and regeneration. In cancer therapy, exosomes can deliver therapeutic agents directly to tumor cells. In gene therapy, exosomes serve as vectors for gene delivery. As diagnostic biomarkers, they are useful in diagnosing various diseases. Challenges such as the isolation, purification, and characterization of exosomes were identified. Current clinical trials demonstrate the potential of exosome-based therapies, though they also reveal significant hurdles. Regulatory issues, including the need for standardization and validation of exosome products, are critical for advancing these therapies. While significant progress has been made in understanding exosome biology, further research is essential to fully unlock their clinical potential. Addressing challenges in isolation, purification, and regulatory standardization is crucial for their successful application in clinical practice. This review provides a concise overview of the clinical applications of exosomes, emphasizing both their therapeutic promise and the obstacles that need to be overcome.
Exploring the Factors in the Discontinuation of a Talent Pool Information System: A Case Study of an EduTech Startup in Indonesia
Authors: Nurwardani Sabila , Zayyan Ailsa , Astuti Endah Fuji , Putra Panca O. Hadi
Published: July 2024

This research was conducted to determine the reasons behind users’ discontinuation of talent pool information system use. A qualitative approach was chosen to explore these factors in depth. Respondents were selected using purposive sampling techniques, and the data collection process was carried out through semi-structured interviews. The thematic analysis method was then applied to the transcripts of the interviews with the users. Based on the qualitative methodology employed, we found seven factors behind users’ discontinuation of the use of the studied information system. The seven factors were grouped based on two dimensions, namely, experiential factors and external factors. Poor system quality, informational issues, interface issues, and unfamiliarity with the system influenced the experiential factors. On the other hand, the external factors were influenced by workforce needs, talent mismatches, and a lack of socialization. This research offers a novel, in-depth analysis of the factors that cause users to stop using information systems based on direct experience from users. In addition, the results of this study will be used as feedback companies can use to improve their systems.
Validation of a Numerical Model for Novel Self-Centring Concentrically Braced Steel Frames
Authors: O’Reilly Gerard J. , Goggins Jamie
Published: July 2024

Significant inelastic deformations induced in structural systems lead to structures possibly possessing some degree of permanent lateral deformation following major seismic events. These permanent deformations have led to considerable research being conducted over the past 20 years into developing structural systems that exhibit self-centring behaviour. For a structural system such as the concentrically braced frame (CBF), for which the dissipating mechanism is the tensile yielding and compressive buckling of the diagonal steel tubular members, these residual deformations present a problem when considering the structure’s overall resilience to the seismic loading both during and after an event. This paper describes the numerical modelling of a novel self-centring, concentrically braced frame (SC-CBF) system that combines a conventional CBF with a self-centring arrangement to produce a structure that possesses the desirable lateral load-resisting capacity of the CBF but which also re-centres when subjected to many cycles of large inelastic brace deformation. First, an experimental test programme for the SC-CBF is briefly described, followed by a numerical model to capture the SC-CBF’s characteristics during cyclic loading. This numerical model is validated using the experimental test data, showing that the experimental and numerical simulation data match rather well. This development presents a platform upon which further research through experimental testing and numerical simulation can be conducted. The proposed SC-CBF system can then be developed into a viable lateral load-resisting system that will provide a more resilient system than the current conventional CBF.
Metalloborospherene Analogs to Metallofullerene
Authors: Burkhardt Jordan , Prescott Hayden , Li Wan-Lu
Published: July 2024

Boron, the neighbor element to carbon in the periodic table, is characterized by unique electron deficiency that fosters multicenter delocalized bonding, contributing to its diverse chemistry. Unlike carbon cages (fullerenes), which preserve their structural integrity under endohedral or exohedral doping, larger boron cages (borospherenes) exhibit diverse structural configurations. These configurations can differ from those of pure boron cages and are stabilized by various metals through unique metal–boron bonding, resulting in a variety of metalloborospherenes. Due to boron’s electron deficiency, metalloborospherenes exhibit fascinating chemical bonding patterns that vary with cluster size and the type of metal dopants. This review paper highlights recent advancements in metalloborospherene research, drawing comparisons with metallofullerenes, and focuses on the use of transition metals, lanthanides, and actinides as dopants across various cage dimensions.
Improved Production of Novel Radioisotopes with Custom Energy Cyclone® Kiube
Authors: do Carmo Sergio J. C. , Neves Ângela C. B. , Kral Eric , Geets Jean-Michel , Nactergal Benoit , Abrunhosa Antero J. , Alves Francisco
Published: July 2024

The implementation of the Variable Energy (VE) feature in the previously fixed-energy IBA Cyclone® Kiube cyclotron is presented as an upgrade enabling the production of novel radioisotopes with improved radionuclidic purity and production yields. The possibility of easily decreasing the energy of the extracted proton beam, from 18 down to 13 MeV, allows us to avoid the use of degraders and/or thick target windows, thus preventing related beam current limitations. The immediate application of the Variable Energy feature is proven by presenting the improved results obtained for the production of 68Ga from the irradiation of liquid targets simultaneously in terms of radionuclidic purity and activity produced.
Exploring the Usefulness of a Multi-Sensory Environment on Sensory Behaviors in Children with Autism Spectrum Disorder
Authors: De Domenico Carmela , Di Cara Marcella , Piccolo Adriana , Settimo Carmela , Leonardi Simona , Giuffrè Grazia , De Cola Maria Cristina , Cucinotta Fabio , Tripodi Emanuela , Impallomeni Caterina , Quartarone Angelo , Cucinotta Francesca
Published: July 2024

Background: Autism spectrum disorder (ASD) is a complex neurological development with social and communication deficits and sensory abnormalities. Sensory problems have a significant impact on daily life. Multisensory environments (MSEs), such as Snoezelen® rooms, offer controlled sensory stimulation. This study aims to evaluate the effect of MSE intervention with self-controlled sensory interactions on adaptive developmental skills and sensory responses in preschool ASD children. Methods: This pilot study was single-blind, randomized, controlled, and adhered to the CONSORT guidelines. Twenty participants were recruited and randomized into two groups: the control group (CG) underwent treatment as usual (TAU) with individual rehabilitation sessions of psychomotor therapy. The experimental group (EG) underwent TAU integrated with the use of an MSE. Developmental abilities and severity levels were assessed, pre-post, with the Psychoeducational Profile, Third Edition (PEP-3) and the Second Edition Childhood Autism Rating Scale (CARS-2). Results: A significant difference in taste, smell, and tactile behaviors according to the CARS-2, as well as in gross motor skills according to the PEP-3, was observed in the EG. Conclusions: This pilot study suggests that MSE-integrated intervention may be a valid strategy to improve self-management of the sensory profile in autistic individuals. Further studies are needed to better identify the intervention methodology and effectiveness.
Myocardial Ischemia: Differentiating between Epicardial Coronary Artery Atherosclerosis, Microvascular Dysfunction and Vasospasm in the Catheterization Laboratory
Authors: Monizzi Giovanni , Di Lenarda Francesca , Gallinoro Emanuele , Bartorelli Antonio Luca
Published: July 2024

Ischemic heart disease is currently the most common cause of mortality and morbidity worldwide. Although myocardial ischemia is classically determined by epicardial coronary atherosclerosis, up to 40% of patients referred for coronary angiography have no obstructive coronary artery disease (CAD). Ischemia with non-obstructive coronary artery disease (INOCA) has typically been underestimated in the past because, until recently, its prognostic significance was not completely clear. This review aims to highlight differences and patterns in myocardial ischemia caused by epicardial obstructive CAD, coronary microvascular dysfunction (CMD) or vasomotor abnormalities and to elucidate the state of the art in correctly diagnosing these different patterns.
The Effect of Cardiac Resynchronization Therapy on Right Ventricular Function: A Systematic Review and Meta-Analysis
Authors: Sidiropoulos Georgios , Karakasis Paschalis , Antoniadis Antonios , Saplaouras Athanasios , Karamitsos Theodoros , Fragakis Nikolaos
Published: July 2024

Background: Right ventricular (RV) failure is an important predicting factor regarding overall and event-free survival regardless of baseline left ventricular (LV) function in patients with severe heart failure (HF). Previous studies have indicated that cardiac resynchronization therapy (CRT) improves LV and RV reverse remodeling in patients with systolic dyssynchrony within the left ventricle. However, there is conflicting evidence regarding the role of CRT in RV function. The aim of this systematic review and meta-analysis was to examine the implications of CRT on RV function indices. Methods: A systematic literature search was conducted using the MedLine and EMBASE databases and the Cochrane Library from their inception until 18 March 2024. Eligible were studies providing information on RV function indices, both at baseline and after CRT. Evidence was summarized using random-effects meta-analytic models. Results: In total, 30 studies were deemed eligible. CRT resulted in a significant improvement in right ventricular fractional area change (mean difference (MD) 5.11%, 95% confidence interval (CI) 2.83 to 7.39), tricuspid annular plane systolic excursion (TAPSE, MD 1.63 mm, 95% CI 1.10 to 2.16), and myocardial systolic excursion velocity (MD 1.85 cm/s, 95% CI 1.24 to 2.47) as well as a significant decrease in pulmonary artery systolic pressure (MD −6.24 mmHg, 95% CI −8.32 to −4.16). A non-significant effect was observed on TAPSE to PASP ratio and right ventricular global longitudinal strain. Conclusions: Our meta-analysis demonstrates that CRT is associated with a significant improvement in echocardiographic parameters of RV function. Further investigation is necessary to elucidate how these changes, both independently and in conjunction with LV improvement, impact patients’ long-term prognosis, and to identify the specific patient populations expected to derive the greatest benefit.
Comparison of Analgesic Method in Laparoscopic Gastrectomy Using External Oblique Intercostal Block Versus Wound Infiltration: A Randomized Controlled Trial
Authors: Suzuka Takanori , Tanaka Nobuhiro , Kadoya Yuma , Yamanaka Takayuki , Ida Mitsuru , Nakade Hiroshi , Kunishige Tomohiro , Matsumoto Sohei , Ozu Naoki , Kawaguchi Masahiko
Published: July 2024

Background: External oblique intercostal block (EOIB) is effective in relieving pain in the T6 to T10 dermatomes; however, there is limited evidence comparing EOIB with conventional regional anesthesia. In this randomized controlled trial, it was hypothesized that EOIB would provide more effective analgesia than wound infiltration (WI) in laparoscopic gastrectomy. Methods: Thirty-two patients (aged 20–85 years) with American Society of Anesthesiologists Performance Status of 1 to 2, scheduled for laparoscopic gastrectomy, were randomly divided into EOIB and WI groups. Both procedures were performed using 40 mL of 0.25% levobupivacaine. The primary outcome was the numerical rating scale (NRS) score 12 h postoperatively. Secondary outcomes were NRS at 2, 24, and 48 h postoperatively, variation in quality of recovery-15 score on postoperative days 1 and 2 from preoperative baseline, postoperative fentanyl consumption, and variation in World Health Organization Disability Assessment Scale 2.0 scores between baseline and 3 months postoperatively. Plasma concentrations of levobupivacaine and pinprick sensation in the T4–11 dermatomes post-EOIB were evaluated to determine the exploratory endpoints. Results: There were no differences in the NRS scores 12 h postoperatively at rest and during movement between the EOIB and WI groups (mean standard deviation 1.3 [1.1] vs. 1.5 [1.4] and 3.1 [1.6] vs. 3.8 [1.7], respectively). Secondary outcomes did not differ significantly between the groups. The time to peak plasma concentration of levobupivacaine following EOIB was 45 min. Conclusions: No significant differences in NRS scores were observed between the analgesic effects of EOIB and WI at 12 h postoperatively.
Implementation of a Co-Design Strategy to Develop a Dashboard to Support Shared Decision Making in Advanced Cancer and Chronic Kidney Disease
Authors: Morken Victoria , Perry Laura M. , Coughlin Ava , O’Connor Mary , Chmiel Ryan , Xinos Stavroula , Peipert John Devin , Garcia Sofia F. , Linder Jeffrey A. , Ackermann Ronald T. , Kircher Sheetal , Mohindra Nisha A. , Aggarwal Vikram , Weitzel Melissa , Nelson Eugene C. , Elwyn Glyn , Van Citters Aricca D. , Barnard Cynthia , Cella David , Hirschhorn Lisa R.
Published: July 2024

Background: Shared decision making (SDM) is the process by which patients and clinicians exchange information and preferences to come to joint healthcare decisions. Clinical dashboards can support SDM by collecting, distilling, and presenting critical information, such as patient-reported outcomes (PROs), to be shared at points of care and in between appointments. We describe the implementation strategies and outcomes of a multistakeholder collaborative process known as “co-design” to develop a PRO-informed clinical dashboard to support SDM for patients with advanced cancer or chronic kidney disease (CKD). Methods: Across 14 sessions, two multidisciplinary teams comprising patients, care partners, clinicians, and other stakeholders iteratively co-designed an SDM dashboard for either advanced cancer (N = 25) or CKD (N = 24). Eligible patients, care partners, and frontline clinicians were identified by six physician champions. The co-design process included four key steps: (1) define “the problem”, (2) establish context of use, (3) build a consensus on design, and (4) define and test specifications. We also evaluated our success in implementing the co-design strategy using measures of fidelity, acceptability, adoption, feasibility, and effectiveness which were collected throughout the process. Results: Mean (M) scores across implementation measures of the co-design process were high, including observer-rated fidelity and adoption of co-design practices (M = 19.1 on a 7–21 scale, N = 36 ratings across 9 sessions), as well as acceptability based on the perceived degree of SDM that occurred during the co-design process (M = 10.4 on a 0 to 12 adapted collaboRATE scale). Capturing the feasibility and adoption of convening multistakeholder co-design teams, min–max normalized scores (ranging from 0 to 1) of stakeholder representation demonstrated that, on average, 95% of stakeholder types were represented for cancer sessions (M = 0.95) and 85% for CKD sessions (M = 0.85). The co-design process was rated as either “fully” or “partially” effective by 100% of respondents, in creating a dashboard that met its intended objective. Conclusions: A co-design process was successfully implemented to develop SDM clinical dashboards for advanced cancer and CKD care. We discuss key strategies and learnings from this process that may aid others in the development and uptake of patient-centered healthcare innovations.
Minimally Invasive Surgery through Right Mini-Thoracotomy for Mitral Valve Infective Endocarditis: Contraindicated or Safely Possible?
Authors: Franz Maximilian , Aburahma Khalil , Ius Fabio , Ali-Hasan-Al-Saegh Sadeq , Boethig Dietmar , Hertel Nora , Zubarevich Alina , Kaufeld Tim , Ruhparwar Arjang , Weymann Alexander , Salman Jawad
Published: July 2024

Background: Mitral valve infective endocarditis (IE) still has a high mortality. Minimally invasive mitral valve surgery (MIMVS) is technically more challenging, especially in patients with endocarditis. Here, we compare the early postoperative outcome of patients with endocarditis and other indications for MIMVS. Methods: Two groups were formed, one consisting of patients who underwent surgery because of mitral valve endocarditis (IE group: n = 75) and the other group consisting of patients who had another indication for MIMVS (non-IE group: n = 862). Patients were observed for 30 postoperative days. Data were retrospectively reviewed and collected from January 2011 to September 2023. Results: Patients from the IE group were younger (60 vs. 68 years; p < 0.001) and had a higher preoperative history of stroke (26% vs. 6%; p < 0.001) with neurological symptoms (26% vs. 9%; p < 0.001). No difference was seen in overall surgery time (211 vs. 206 min; p = 0.71), time on cardiopulmonary bypass (137 vs. 137 min; p = 0.42) and aortic clamping time (76 vs. 78 min; p = 0.42). Concerning postoperative data, the IE group had a higher requirement of erythrocyte transfusion (2 vs. 0; p = 0.041). But no difference was seen in the need for a mitral valve redo procedure, bleeding, postoperative stroke, cerebral bleeding, new-onset dialysis, overall intubation time, sepsis, pacemaker implantation, wound healing disorders and 30-day mortality. Conclusions: Minimally invasive mitral valve surgery in patients with mitral valve endocarditis is feasible and safe. Infective endocarditis should not be considered as a contraindication for MIMVS.
Early Outcomes of Two Large Mitral Valve Transcatheter Edge-to-Edge Repair Devices—A Propensity Score Matched Multicenter Comparison
Authors: von Stein Philipp , Wienemann Hendrik , von Stein Jennifer , Sugiura Atsushi , Tanaka Tetsu , Kavsur Refik , Öztürk Can , Weber Marcel , Haurand Jean Marc , Horn Patrick , Kister Tobias , Mahabadi Amir Abbas , Boeder Niklas , Ruf Tobias , Gerçek Muhammed , Mues Christoph , Grothusen Christina , Novotny Julia , Weckbach Ludwig , Guthoff Henning , Rudolph Felix , Polzin Amin , Baldus Stephan , Rassaf Tienush , Thiele Holger , Möllmann Helge , Kelm Malte , Rudolph Volker , von Bardeleben Ralph Stephan , Nef Holger , Luedike Peter , Lurz Philipp , Hausleiter Jörg , Pfister Roman , Mauri Victor
Published: July 2024

Background/Objectives: Previous trials reported comparable results with PASCAL and earlier MitraClip generations. Limited comparative data exist for more contemporary MitraClip generations, particularly the large MitraClip XT(R/W). We aimed to evaluate acute and 30-day outcomes in patients undergoing mitral valve transcatheter edge-to-edge repair (M-TEER) with one of the large devices, either PASCAL P10 or MitraClip XT(R/W) (3rd/4th generation). Methods: A total of 309 PASCAL-treated patients were matched by propensity score to 253 MitraClip-treated patients, resulting in 200 adequately balanced pairs. Procedural, clinical, and echocardiographic outcomes were collected for up to 30 days, including subgroup analysis for mitral regurgitation (MR) etiologies. Results: PASCAL and MitraClip patients were comparable regarding age (80 vs. 79 years), sex (female: 45.5% vs. 50.5%), and MR etiology (degenerative MR: n = 94, functional MR [FMR]: n = 96, mixed MR: n = 10 in each group). Technical success rates were comparable (96.5% vs. 96.0%; p > 0.999). At discharge, the mean gradient was higher (3.3 mmHg vs. 3.0 mmHg; p = 0.038), and the residual mitral valve orifice area was smaller in MitraClip patients (3.0 cm2 vs. 2.3 cm2; p < 0.001). At discharge, the reduction to MR ≤ 2+ was comparable (92.4% vs. 87.8%; p = 0.132). However, reduction to MR ≤ 1+ was more frequently observed in PASCAL patients (67.7% vs. 56.6%; p = 0.029), driven by the FMR subgroup (74.0% vs. 60.0%; p = 0.046). No difference was observed in 30-day mortality (p = 0.204) or reduction in NYHA-FC to ≤II (p > 0.999). Conclusions: Both M-TEER devices exhibited high and comparable rates of technical success and MR reduction to ≤2+. PASCAL may be advantageous in achieving MR reduction to ≤1+ in patients with FMR.
Smoothed Particle Hydrodynamics Modelling of Bergy Bit and Offshore Structure Interactions Due to Large Waves
Authors: Islam Mohammed , Sayeed Tanvir
Published: July 2024

This research utilised an open-sourced smoothed particle hydrodynamics (SPH) tool to model and predict the change in wave-induced forces and motions of a free-floating bergy bits approaching a fixed structure in regular waves. Simulation parameters, including particle resolution, fluid viscosity, initial wave condition and boundary treatments, are varied, and their effect on the load imparted to the bergy bit and the structure are investigated. The predicted motions are compared with previously published physical measurements for corresponding scenarios. Both predictions and measurements showed that, in regular waves, the surge motion slowed as the bergy bit approached the structure, and the heave motion increased. For wave loading on bergy bits, the agreement with the experimental data for the root mean square (RMS) force was within 2%. The pressure and velocity fields of the wave–structure–bergy bit interactions are discussed in light of the SPH predictions. This work confirms that the SPH model can accurately capture viscosity–dominated interactions, hydrodynamic damping, and eccentric impact like phenomena and predict both the impact and hydrodynamic loads due to a bergy bit drifting in waves towards a fixed offshore structure.
Ship Emission Measurements Using Multirotor Unmanned Aerial Vehicles: Review
Authors: Šaparnis Lukas , Rapalis Paulius , Daukšys Vygintas
Published: July 2024

This review investigates the ship emission measurements using multirotor unmanned aerial vehicles (UAVs). The monitoring of emissions from shipping is a priority globally, because of the necessity to reduce air pollution and greenhouse gas emissions. Moreover, there is widespread global effort to extensively measure vessel fuel sulfur content (FSC). The majority of studies indicate that more commonly used methods for measuring ship emission with UAVs is the sniffing method. Most of the research is concerned with determining the fuel sulfur content. Fuel sulfur content can be determined by the ratio of CO2 and SO2 concentration in the exhaust gas plume. For CO2, the non-dispersive infrared (NDIR) method is used, the most common measuring range reaches 0–2000 ppm, the overall measuring range 0–10,000 ppm, and detection accuracy is ±5–300 ppm. For SO2, the electrochemical (EC) method is used, the measuring range reaches 0–100 ppm, and the detection accuracy is ±5 ppm. Common UAV characteristics, used in measurement with ships, involve the following: 8–10 m/s of wind resistance, 5–6 kg maximum payload, and a flight distance ranging from 5 to 10 km. This can change in the near future, since a variety of emission measuring devices that can be mounted on UAVs are available on the market. The range of available elements differs from device to device, but available ranges are allowed and the accuracy provides good possibilities for wider research into ship emissions.
Laboratory Study on Wave Attenuation by Elastic Mangrove Model with Canopy
Authors: Lu Youxiang , Luo Yongjun , Zeng Jian , Zhang Zhiyong , Hu Jielong , Xu Yanan , Cheng Wenlong
Published: July 2024

This study evaluates the effectiveness of artificial Kandelia obovata forests in wave attenuation through physical model experiments conducted in a wave flume. The experiments meticulously replicated real-world hydrodynamic conditions and mangrove movement responses using the principles of gravitational and motion similarity, with a scaled 1:10 model of Kandelia obovata. Our approach included comparative experiments against a 1:100 gradient concrete slope to isolate the effects of seabed friction and flume wall reflections. The wave height was measured using strategically placed wave gauges. The findings indicated that the artificial Kandelia obovata forests significantly attenuated waves, with a decrease in the total attenuation capacity as the water depth increased from 2.75 m to 3.28 m under both regular and irregular waves. The elastic mangrove model with a canopy effect led to a 15% increase in wave attenuation over cylindrical models. Predictive models using multivariate nonlinear regression and back propagation neural networks showed that the latter provided a superior accuracy in estimating wave transmission coefficients
Unveiling Turbulent Flow Dynamics in Blind-Tee Pipelines: Enhancing Fluid Mixing in Subsea Pipeline Systems
Authors: Han Fenghui , Lan Qingyuan , Liu Yuxiang , Yin Guang , Ong Muk Chen , Li Wenhua , Wang Zhe
Published: July 2024

Blind tees, as important junctions, are widely used in offshore oil and gas transportation systems to improve mixing flow conditions and measurement accuracies in curved pipes. Despite the significance of blind tees, their unsteady flow characteristics and mixing mechanisms in turbulent flow regimes are not clearly established. Therefore, in this study, Unsteady Reynolds-Averaged Navier–Stokes (URANS) simulations, coupled with Explicit Algebraic Reynolds Stress Model (EARSM), are employed to explore the complex turbulent flow characteristics within blind-tee pipes. Firstly, the statistical flow features are investigated based on the time-averaged results, and the swirl dissipation analysis reveals an intense dissipative process occurring within blind tees, surpassing conventional elbows in swirling intensity. Then, the instantaneous flow characteristics are investigated through time and frequency domain analysis, uncovering the oscillatory patterns and elucidating the mechanisms behind unsteady secondary flow motions. In a 2D-length blind tee, a nondimensional dominant frequency of oscillation (Stbt = 0.0361) is identified, highlighting the significant correlation between dominant frequencies inside and downstream of the plugged section, which emphasizes the critical role of the plugged structure in these unsteady motions. Finally, a power spectra analysis is conducted to explore the influence of blind-tee structures, indicating that the blind-tee length of lbt = 2D enhances the flow-mixing conditions by amplifying the oscillation intensities of secondary flow motions.
Recognition and Prediction of Multi-Level Handling Complexity at Automated Terminals Based on ARIMA
Authors: Ma Yong , Li Junjun
Published: July 2024

Accurate recognition and prediction of the multi-level handling complexity in automated container terminals (referred to as “automated terminals”) is a prerequisite for improving the effectiveness of scheduling and realizing intelligent operation and maintenance. According to the operating characteristics of the automated terminal equipment, the operating network is constructed of automated terminals that describe the characteristics of operating complexity. We use K-medoids and a light gradient boosting machine (LightGBM) to construct a K-LightGBM model that recognizes multi-level handling complexity. The key lies in the reasonable construction of prediction models. A hyper-heuristic autoregressive integrated moving average (ARIMA) model is proposed to address the problem that the ARIMA is ineffective in predicting nonlinear data. We combine ARIMA and the LightGBM model to establish an ARIMA-LightGBM model to predict multi-level handling and residuals. To improve accuracy, we propose the two residual prediction strategies of direct prediction and limited residual boundary prediction based on the residuals generated by ARIMA. We propose a hyper-heuristic algorithm based on a gradient descent-trust region (GD-TR) to compute the weights of predicted values under the two strategies, which improves the global search capability by GD and TR. The particle swarm optimization algorithm, simulated annealing algorithm, and ant colony optimization algorithm are low-level heuristics. Simulation results show that the proposed model possesses the lowest root mean square error on all characteristics compared to ARIMA, E-ARIMA, and ARIMA-LSTM. Therefore, the proposed model is very effective in improving the accuracy of predicting the multi-level handling complexity at automated terminals.
A Study of the Relationship between Sand Movement and Flow Field Distribution and Wear Causes in a Multiphase Pump
Authors: Guo Xin , Shi Guangtai , Xiao Yexiang , Ye Xunyun
Published: July 2024

The Rosin–Rammler function is used in this paper to model the diameter distribution of sand particles. It investigates the characteristics of sand distribution and identifies the primary factors contributing to wear on flow components in a blade-type multiphase pump, considering varying particle sizes. The result of research shows that the blade head of the impeller and the middle section of the flow passage in the diffuser domain represent primary areas prone to sand particle accumulation. The concentration of sand particles within the diffuser surpasses that within the impeller, yet wear severity and extent are more pronounced in the impeller domain compared to the diffuser domain. Meanwhile, the movement trajectory of sand particles is linked to both shear flow and vortex flow. The wear of the front section of the impeller blade is more severe than the second half. On the pressure surface of the blade, particle Reynolds number emerges as a primary factor influencing wear, while on the suction surface, sand particle concentration plays a dominant role in determining wear. The particle concentration in the diffuser domain is the primary factor influencing wear on both the suction and pressure surfaces. The wear rate in the impeller is primarily influenced by the sand particle Reynolds number, whereas the wear rate in the diffuser domain is affected by a combination of sand particle diameter, sand particle concentration, and sand particle Reynolds number. The research findings possess significant engineering value in terms of enhancing the operational lifespan of multiphase pumps.
Numerical Simulation of Gas Production Behavior Using Radial Lateral Well and Horizontal Snake Well Depressurization Mining of Hydrate Reservoir in the Shenhu Sea Area of the South China Sea
Authors: Wan Tinghui , Wen Mingming , Lu Hongfeng , Li Zhanzhao , Chen Zongheng , Tian Lieyu , Li Qi , Qu Jia , Wang Jingli
Published: July 2024

Improving the production capacity of natural gas hydrates (NGHs) is crucial for their commercial development. Based on the data of the first on-site testing production of NGHs in the Shenhu Sea area, numerical methods were used to analyze the production behavior of radial lateral well (RLW) and horizontal snake well (HSW) with different completion lengths when they deployed at different layers of the Class-1 type hydrate reservoir (with a fixed pressure difference of 6 MPa and continuous production for 360 days). The results indicate that compared with the single vertical well production, RLW and HSW can effectively increase production capacity by enlarging drainage area and the productivity is directly proportional to the total completion length. The RLW and HSW deployed at the three-phase layer (TPL) have optimal mining performance within a 360-day production period. Different to the previous research findings, during a short-term production period of 360 days, regardless of the deployment layer, the overall production capacity of HSW is better than RLW’s. The total gas production of HSW-2 circles well type is about four times that of a single vertical well, reaching 1.554 × 107 ST m3. Moreover, the HSW-1 lateral well type stands out with an average Qg of 3.63 × 104 ST m3/d and a specific production index J of 16.93; it has the highest J-index among all well types, which means the best mining efficiency. It is recommended to choose the HSW-1 circle well type, if the coiled tubing drilling technique is used for on-site testing production of NGHs in the future. The research results provide insights into the potential applications of RLW and HSW in this sea area.
Results of Tendon Transfers in Radial Nerve Palsies: A New Evaluation Protocol
Authors: Reina Micaela , Odella Simonetta , Magnani Mauro , Locatelli Francesco , Clemente Alice , Macrì Martina , Tos Pierluigi
Published: July 2024

Radial nerve palsies present a challenging clinical scenario, often leading to substantial functional impairment. This study focuses on evaluating the outcomes of tendon transfer surgeries in patients with post-traumatic radial nerve injuries. The radial nerve, vital for upper limb movements, faces various etiologies, such as trauma, compression, or idiopathy. Patients with radial nerve palsy encounter difficulties in daily activities, emphasizing the need for effective management strategies. The research introduces a novel evaluation protocol, aiming to comprehensively assess tendon transfer outcomes. This protocol incorporates functional movements of wrist and finger joints, encompassing both objective and subjective parameters. The retrospective study includes eleven patients treated between 2010 and 2022, with a minimum follow-up of one year post-surgery. Tendon transfers demonstrated positive results. The evaluation protocol covers a wide range of parameters, including wrist and finger mobility, thumb function, grip strength, and patient satisfaction. The results indicate successful restoration of motor function, with an average grip strength of 70% compared to the healthy arm. The proposed evaluation protocol facilitates standardized and reproducible assessment, minimizing subjective errors in clinical evaluations. Despite the study’s limitations, such as a relatively small sample size, the findings underscore the effectiveness of tendon transfers in treating radial nerve palsies. The introduced evaluation scheme provides a comprehensive and reproducible approach to assess outcomes, contributing to the global standardization of tendon transfer assessments in radial nerve injuries.