bluuebunny/crossref_metadata_2025 huggingface dataset:
Cisplatin, Fluorouracil in Bolus Injection, and Leucovorin in First-Line Therapy for Advanced Gastric Cancer as an Alternative to Protocols With Infusional Fluorouracil
Authors: Coelho Rafael C. , Abreu Pedro D.P. , Monteiro Mariana R. , Stramosk Ana Paula , Garces Alvaro Henrique I. , Melo Andreia Cristina , Graudenz Marcia S. , Andrade Carlos Jose C.
Published: January 2019

PURPOSE

Gastric cancer (GC) is the fourth most common cancer and the second leading cause of cancer death worldwide. Platinum agents and fluoropyrimidines are the main compounds used in the first-line setting for advanced GC. Given the activity of fluorouracil (FU) bolus, the PFL protocol, a chemotherapy regimen combining cisplatin, FU bolus, and leucovorin, was incorporated at the Brazilian National Cancer Institute, because this schedule does not require hospitalization or infusion pumps. This study aims to evaluate the outcomes of PFL in the first-line setting for patients with advanced GC.

MATERIALS AND METHODS

This was a retrospective cohort study evaluating patients with advanced GC treated in the first-line setting with cisplatin 80 mg/m2 on day 1 and FU bolus 400 mg/m2 plus leucovorin 20 mg/m2 on days 1, 8, 15, and 22 every 4 weeks, from January 2008 to December 2014.

RESULTS

A total of 109 patients were enrolled. The median number of cycles received per patient was four (one to 11). Complete responses were achieved in 6.4% and partial responses in 14.7%. Median progression-free survival was 6.3 months (95% CI, 5.08 to 7.58 months) and median overall survival was 8.3 months (95% CI, 6.79 to 9.87 months). Thirty-four (31.2%) patients were alive in 1 year. Grade 3 and 4 adverse events were experienced by 26.6% and 3.7% of patients, respectively, with dose reduction necessary in 9.1%.

CONCLUSION

PFL is active in advanced GC and could be an alternative for FU continuous infusion protocols in institutions with limited resources and/or low budget, which is the reality in many nations all over the world.
Folic acid modifies the shape of epithelial cells during morphogenesis via a Folr1 and MLCK dependent mechanism
Authors: Martin Jessica B. , Muccioli Maria , Herman Kenneth , Finnell Richard H. , Plageman Timothy F.
Published: January 2019

Folic acid supplementation can prevent neural tube defects, but the specific molecular mechanisms by which it does have not been elucidated. During neural plate morphogenesis, epithelial cell apical constriction cooperates with other events to drive tissue-bending, and when defective, can result in neural tube defects. A Rho-kinase deficient binding mutant of the apical constriction regulating protein, Shroom3 (Shroom3R1838C), is one of only a handful of mouse mutant lines with neural tube defects that can be rescued by folic acid supplementation. This provided a unique opportunity to probe the functional rescue of a protein linked to neural tube development by folic acid. Utilizing an epithelial cell culture model of apical constriction, it was observed that treatment with exogenous folic acid, as well as co-expression of the folic acid receptor Folr1, can rescue the function of the Rho-kinase binding deficient mutant of Shroom3 in vitro. It was also determined that the rescuing ability of folic acid is RhoA and Rho-kinase independent but myosin light chain kinase (MLCK) and Src-kinase dependent. Inhibition of Rho-kinase-dependent apical constriction in chick embryo neural epithelium was also observed to be rescued by exogenous folic acid and that treatment with folic acid is accompanied by elevated activated myosin light chain and MLCK. Furthermore, doubly heterozygous mouse embryos lacking one copy each of Shroom3 and Folr1 exhibit a low rate of neural tube defects and also have lower levels of activated myosin light chain and MLCK. These studies suggest a novel mechanism by which folic acid modifies epithelial cell shape during morphogenesis, shedding light onto how folic acid may prevent neural tube defects.
Application of hyperspectral imaging and chemometrics for classifying plastics with brominated flame
retardants
Authors: Caballero Daniel , Bevilacqua Marta , Amigo José
Published: January 2019

Most plastics need to incorporate flame retardants to meet fire safety standards requirements. The amount and the
type of flame retardants can differ, so that in waste plastics a large variety of polymers and flame retardants can be
found. The recycling of plastics containing flame retardants is increasing. However, only plastics of the same polymer type
and the same additive content can be recycled together. Three models based on different chemometrics techniques
applied to hyperspectral imaging in the near infrared range were developed [partial least square-discriminant analysis,
decision tree (DT) and hierarchical model (HM)]. Optimal results were obtained for all classification techniques. HM shows
the highest error at all levels due to the noisy spectra of the black plastics. However, DT classification gave outstanding
results, considering that the sensitivity was higher than 0.9 in all cases. Thus, the application of DT with hyperspectral
imaging could be used to sort plastic samples with respect to the type of polymer and the flame retardant used with a high
degree of accuracy in an automated way. These findings are highly valuable for the plastic and waste management
industries.
Open laboratory notebooks: good for science, good for society, good for scientists
Authors: Schapira Matthieu ,   The Open Lab Notebook Consortium, Harding Rachel J.
Published: January 2019

The fundamental goal of the growing open science movement is to increase the efficiency of the global scientific community and accelerate progress and discoveries for the common good. Central to this principle is the rapid disclosure of research outputs in open-access peer-reviewed journals and on pre-print servers. The next bold step in this direction is open laboratory notebooks, where research scientists share their research — including detailed protocols, negative and positive results — online and in near-real-time to synergize with their peers. Here, we highlight the benefits of open lab notebooks to science, society and scientists, and discuss the challenges that this nascent movement is facing. We also present the implementation and progress of our own initiative at openlabnotebooks.org, with more than 20 active contributors after one year of operation.
Urbolandscape on gully terrain
Authors: Евграфова Ирина , Evgrafova Irina
Published: January 2019

For cities on the complex topography cause the greatest difficulties of the work on the development of gullies and ravines. In this area, there was and there is no standard techniques, which could be used by designers, builders and representatives of the city administrations. In each case it requires consideration not only the regional engineering - geological conditions, but also accumulated environmental domestic and foreign experience. In this paper, the author tried to summarize the experience of urban development of ravines and gullies, not only for construction, but also in cases where they are protected areas. The stages of development urbolandshaftov on the complex topography, physical, climatic and ecological features. A wide list of options for the use of urban ravines and gullies. Effective recommendations are given for the construction of on the complex topography, are examples of many Russian cities. For engineering - technical personnel, environmental engineering and construction companies, as well as students and university teachers.
Newly qualified health visitor: Staff wellbeing and delivering an effective service
Authors: Bewick Jessica
Published: January 2019

Now in the fourth week of working for a new Trust, Jessica Bewick has discovered the impact of support for staff wellbeing on the health visiting service
Considering the risks to children of parental alcohol misuse
Authors: Noakes Amy
Published: January 2019

Health visitors can support families where there is parental alcohol misuse by ensuring the needs of the child are prioritised, says Amy Noakes
Support for professionals after trauma
Authors: Forbes Lisa
Published: January 2019

It is important that health professionals have access to the support we need to manage the emotional response that situations may trigger, says Lisa Forbes
Childhood disorders: MCADD
Authors: Tinsley Elizabeth
Published: January 2019

Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is a lifelong condition that babies are born with and it affects up to 1 in every 8000 births in the UK. It is screened for on the newborn blood spot test performed on day five of life. MCADD can be a serious life-threatening condition if not recognised and treated quickly, but with timely care sufferers can live healthy and active lives.
Embedding a public health approach to maternity transformation
Authors: Coles Tammy
Published: January 2019

Tammy Coles explains how consistent messages delivered by multidisciplinary teams are part of an effort to give children in the East Midlands the best start in life
Research roundup: January 2019
Authors: Odd Dawn , Seal Joanne , Murray Joy
Published: January 2019

In this section, a range of brief synopses of recently published articles that may be of interest to health visitors is presented. The aim of this roundup is to provide an overview, rather than a detailed summary, of the research papers selected. Should you wish to look at any of the papers in more detail, a full reference is provided.
Get into character
Authors: Clarke Jenni
Published: January 2019

Discover how imaginative play based on dressing up and role-play can extend children's understanding of the world and inspire creative art works to represent their experiences.
Against the grain
Authors: Harries Judith
Published: January 2019

Revisit your sand trays with these new ideas to promote concentration, hand-to-eye co-ordination and fine motor skills. Children can also get to grips with how tools can effect changes to materials.
Happily ever after
Authors: White Hilary
Published: January 2019

Hilary White suggests ways to update traditional fairy tales, to make them relevant and meaningful in the context of the modern world, giving children the opportunity to explore characters and events.
Developed Web-based System for Performance Evaluation based on Balanced Scorecard Model: Case Study in Ethiopian Organizations
Authors: MEKONNEN TESSEMA WORKU
Published: January 2019

In this research a developed web–based balanced scorecard performance evaluation system proposed for the case study of Ethiopian organizations and supports both English and Amharic languages. The system incorporates evaluations of individual performance (both in activity and behavior), major activity performance, objective performance, perspective performance, unit/ department performance, and the organization/institute as a whole based on time, cost, quality and quantity. Object oriented software engineering and ASP.NET 4.0 platform is employed to develop the system. Reviewing the overall results from the usability test, questionnaires and interviews, it is concluded that all production and extensive public service providing organizations prefer to use the implemented application but other organizations comparatively didn’t want to use it as it seems it doesn’t facilitate their daily duties. But the overall functionality of the system is being agreed by the users.
Multicenter Evaluation of a High-Sensitivity Troponin I Assay and Verification of an Early Rule-Out Algorithm
Authors: Sharrod-Cole Hayley , Ford Clare
Published: January 2019

Background

The objectives of this study were to independently evaluate the analytical performance of the STAT high-sensitivity troponin I (hs-cTnI) assay on a recently launched and CE-marked integrated chemistry and immunoassay system, confirm acceptable performance of the assay in line with The Third Global MI Task Force recommendations, and confirm suitability of the assay for continued use of an early rule-out algorithm for acute coronary syndrome at our Trust.

Methods

A multicenter evaluation of the analytical performance characteristics of the hs-cTnI assay on the Abbott Alinity ci series was performed in 5 clinical laboratories across Europe. Comparison studies were performed vs the existing Abbott ARCHITECT hs-cTnI assay.

Results

Passing and Bablok regression analysis revealed a slope of 0.99 [95% confidence interval (CI), 0.98–1.00] and an intercept of −0.09 ng/L (95% CI, −0.21–0.11). Intermediate imprecision ranged from 3.7% to 5.4%, 2.6% to 4.5%, and 2.0% to 6.1% at concentrations of 19.1–21.1 ng/L, 196.6–205.5 ng/L, and 15229–16265 ng/L, respectively. There was good concordance between the 2 assays at the early rule-out cutoff.

Conclusion

Comparable analytical performance of the hs-cTnI assay on new Abbott Alinity ci series supports the continued use of the early rule out algorithm for patients with suspected ACS at our Trust.
City of Permanent Temporality
Authors: Boxel Elma Van , Koreman Kristian , Zones Urbaines Sensibles ZUS
Published: January 2019

On July 22nd, 2001, there was the third shooting in a month. The municipality of Rotterdam declared the area around Rotterdam Centraal Station a zero-tolerance zone, installed 360o security cameras, and imposed the umpteenth ban on disreputable bars and clubs; thus, another twenty meters of boarded-up shop fronts. It was 2001; a strange year in which the rise of the right-wing populist politician Pim Fortuyn coincided with Rotterdam’s celebration of cultural diversity as the Cultural Capital of Europe and the announcement that multiculturalism was a failure in the Netherlands. And finally, there was 9/11. On the Hofplein, a major traffic junction in Rotterdam’s city center, these expressions of hope and hopelessness came into sharp focus. Citizens, in search of an appropriate city square, took to occupying the Hofplein roundabout to celebrate or to mourn. The administrative nervousness that arose in this confused period was repeatedly expressed in even stricter policies to keep the city and especially its streets ‘clean, well maintained, and safe.’ Ensuring a lively atmosphere on Rotterdam’s streets was difficult enough, never mind the additional measures being deployed to systematically remove the last traces of the informal use of the public domain.
The Athens Conservatory Concert Hall by Jan Despo
Authors: Andrianopoulos Tilemachos
Published: January 2019

The Athens Conservatory is the only realized building of the Athens Cultural Center -a ’59 urban design composition by Jan Despo. The upper floor Concert Hall served as the Conservatory’s music venue for 40 years, though it remained in an incomplete, decadent state. Before attempting the restoration, a thorough research of the archived drawings revealed a series of elevations and construction drawings of a visually astonishing composition of acoustic panels for the lateral walls -that was never constructed. The discovery of those original drawings highlights the crucial role of research for a well documented, valid restoration
Efficiency of drug therapy for coxitis in patients with ankylosing spondylitis according to the data of a 12-month prospective follow-up
Authors: Petrov A. V. , Beloglazov V. A. , Shevnina Yu. O. , Petrov A. A.
Published: January 2019

Hip joint (HJ) inflammation in ankylosing spondylitis (AS) is a frequent manifestation and an unfavorable prognostic feature of the disease and it requires total hip arthroplasty in 7–8% of patients. Nonsteroidal anti-inflammatory drugs (NSAIDs), sulfasalazine (SSZ), and tumor necrosis factor-α inhibitors are used to treat AS-associated coxitis. However, the influence of these treatments on the time course of HJ structural changes has not been currently studied.Objective: to estimate the time course of HJ changes clinical, X-ray, and ultrasonographic examination was performed in AS patients receiving various drugs: NSAIDs, SSZ, and adalimumab (ADA) during 12 months.Subjects and methods. Seventy-eight AS patients who had clinical, ultrasonographic, and radiological signs of HJ inflammation were followed up. The patients were divided into three groups: 1) 25 patients who took NSAIDs daily; 2) 26 patients who received NSAIDs and SSZ in a daily dose of 2–3 g; 3) 27 patients who were treated with NSAIDs and subcutaneous injections of ADA 40 mg once every 2 weeks. In addition to conventional clinical and laboratory investigations, all the patients underwent radiography with Bath Ankylosing Spondylitis Radiology HIP Index (BASRI-Hip) estimation and HJ ultrasonography.Results and discussion. In Group 2, 12-month SSZ use led to a reduction in median pain intensity during HJ movements on a visual analog scale (VAS) from 26.1 [13.9; 42.7] to 69.3 [56.8; 79.3] mm (p<0.05), CRP levels from 4.4 [1.5; 6.9] to 15.2 [8.3; 21.8] mg/l (p<0.05), and synovial membrane thickness from 6.7 [5.8; 8.5] to 9.6 [7.9; 11.8] mm (p<0.05) compared to the basic data. In Group 3, ADA administration resulted in pain reduction from 14.2 [5.2; 26.7] to 72.1 [65.3; 89.1] mm (p<0.05), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score based on C-reactive protein (ASDAS-CRP) from 1.7 [1.1; 3.1] and 1.4 [1.1; 2.2] to 7.5 [5.9; 8.6] and 3.1 [2.6; 3.9], respectively (p<0.05), CRP levels from 2.7 [0.2; 5.8] to 24.3 [17.4; 35.9] mg/l (p<0.05), and HJ synovial membrane thickness from 6.3 [5.0; 7.7] to 9.9 [8.1; 12.6] mm (p<0.05). SSZ and ADA did not substantially affect the time course of changes in BASRI-Hip and the process of new osteophyte formation in HJ.Conclusion. The use of SSZ and ADA in the complex treatment of patients with AS-associated coxitis leads to a lower HJ synovitis activity.
Current strategy in the treatment of calcium pyrophosphate crystal deposition disease
Authors: Vladimirov S. A. , Eliseev M. S.
Published: January 2019

The paper considers currently available drugs used to treat calcium pyrophosphate crystal deposition disease. It discusses the advantages and disadvantages of the most widely used drugs, such as  nonsteroidal anti-inflammatory drugs, colchicine, glucocorticoids, traditional immunosuppressants, as well as prospects for the use of biologic agents.
Behсet's disease: intestinal damage
Authors: Goloeva R. G. , Alekberova Z. S.
Published: January 2019

Behсet's disease (BD) is a systemic vasculitis of an unknown etiology characterized by repeated oral and genital ulcerations and involvement of the eyes, joints, blood vessels, and other organs. In BD, it is the organ pathology that determines the severity and prognosis of the disease. The most difficult and least studied version of such changes is intestinal damage. Its verification in BD is complicated by a variety of clinical manifestations, their similarity with inflammatory bowel diseases, the lack of sufficiently informative laboratory tests, and pathognomonic endoscopic and histological signs. Intestinal BD (IBD) can result in serious complications (severe bleeding, intestinal perforation, and fistula formation), which may not only considerably reduce the quality of life of the patient, but also cause his death. Treatment for IBD is not standardized; it is mainly empirical and is performed as cycles. The goal of its therapy is to achieve clinical remission, to heal intestinal ulcers, to reduce recurrence rates, and to prevent surgery. The cumulative frequency of surgical interventions is as follows: 20% of them are performed in the first year, 27–33% within 5 years, and 31–46% within 10 years after IBD diagnosis. One of the problems in the surgical treatment of patients with IBD is the risk of a recurrence that often requires repeat surgery. Thus, 2- and 5-year postoperative recurrence rates were 29.2 and 47.2%, respectively. The poor prognostic factors are young age (<40 years), high disease activity at the time of diagnosis, detection of crateriform or deep ulcers at colonoscopy, high C-reactive protein level, and history of laparotomy.
Keberpihakan al-Qur’an Terhadap Mustadh’afin
Authors: Sholehah Iffatus
Published: January 2019

Crisis problematic stereotypes that can not be separated from human life from the time of the Prophet until today, namely mustadh'afin. Mustadh'afin here normally understood by people who are weak as a group in the economy as poor, beggars, orphans, slaves and women. To some people, they are all considered groups were weak and helpless and stereotypes of this kind still exist today. Therefore, how the Qur'an as a guide to answer all of this human's life. Because the Qur'an always be the answer to all the problems that arise. Stated that the Qur'an has a feature on each of His verses, including their support to mustadh'afin. This study uses literature research. The purpose of writing this article to explain the teachings of Islam which can be said to be close to the favor of the underprivileged. To frame this study, the authors discuss a little more about the verses that speak of their support to mustadh'afin. Even this can be evidenced by the many verses that speak about mustadh'afin once talked to worship mahdhah (vertical worship), for example prayer, fasting, zakat and others. This shows that paying attention to the underprivileged as important as the obligation of prayer, fasting, pilgrimage and so on. Therefore, on the impartiality of the Qur'an against mustadh'afin will be discussed in this scientific article.
LIVING ISLAM Apa dan Mau ke Mana?
Authors: Zuhri H.
Published: January 2019

Discussing the Islam in the context of everyday life, in various aspects, perspectives, and wide variety of geo- graphical field, can be replicated with the term of Living Islam. Islam in the society is now understood by a set of methodologies and scientific paradigms and has been carried out by intellectuals from both internal Islam such as Akbar S. Ahmed and from external Islam as Islamic anthropology or anthropology about Islam. Whatever the name suggests, anthropology still impressed only the human dimension, Living Islam offers a comprehensive perspective and integrated with various other scientific disciplines. This paper seeks to define living Islam in society theoretically with a framework of thought and practical research methods that can be used as a guide for research on Living Islam.
Radikalisme dan Kaum Muda Dalam Perspektif Sosiologi
Authors: Supriadi Endang
Published: January 2019

Lately radicalism in Indonesia is still warmly discussed. This phenomenon is a serious problem for the community. The organizational network of radicalism does not appear to be conspicuous, but if further examined lately the real threat of radicalism reemerged in Indonesia. This can not be separated from the other side of freedom of democrati- zation. The character or the soul of Indonesia as a nation, often called religus, friendly, tolerant, peaceful, gotong royong, and so on, is now being eroded and experiencing massive degradation. This paper will review the develop- ment of radicalism in Indonesia which in fact young people become agents in the process of the birth of radicalism in the perspective of sociology—the identity of young people as the next generation of the nation is at stake; how far they understand the question of radicalism in Indonesia; and youth radicalism can be seen as a response, criticism and antithesis, to orthodoxy and the mainstream that occurs in power relationships that can take the form of violence and nonviolence.
TEOLOGI PLURALIS: Studi Living Islam di Dusun Gunung Sari, Sambirejo, Prambanan, Sleman, Yogyakarta
Authors: Muzairi Muzairi , Arif Muhammad
Published: January 2019

Although large-scale religious conflicts such as the Ambon and Poso cases have ended, it does not mean that Indonesia has been able to get out of the danger zone of violence, which is based on religion. One of the latent dangers of religious-based violence can be found in Gunung Sari, Sambirejo, Prambanan, Sleman, Yogyakarta, in which there are three Islamic groups: NU, Muhammadiyah, and  Islam-Tawheed. Each group member has a different view, from religious rituals to their social interactions, even physical conflicts have occurred between them. For this reason, we are inte- rested in doing research as well as living there. Based on our research, it was found that no longer true of what Ahmad Salehudin had described in his previous research, today they appreciate religious differences and views about religion among them. Slowly but surely, they have practiced a pluralist theology (living Islam).
SPIRITUALITAS DAN GENDER: Sufi-Sufi Perempuan
Authors: Maulana M. Iqbal
Published: January 2019

Today there have been many studies of Sufism, but not many studies have discussed the involvement and contribution of women in the realm of Islamic mysticism in particular. This fact cannot be used as an excuse to say that Sufism, especially Islam, completely ignores the position and contribution of women. The few studies, once again, cannot be used as an excuse that women have little contribution and position in the development and spread of Sufism's teachings, doctrines and prac- tices.This paper discusses the equality of women and men not only in the conceptual level as stated in the Qur'an and Hadith. Furthermore, a number of female Sufi fig- ures such as Rabi'ah Adawiyah, Aishah al-Ba'uniyyah, Jahan Malek Khatun, Mahsati Ganjavi (Persia), Habba Khatoon, Jahanara Begum (India), were shown, which proved that women had equal opportunities in achieving spiritual knowledge.
Barriers to firm growth in open economies
Authors: Piguillem Facundo , Rubini Loris
Published: January 2019

Studies measuring barriers to firm growth assume economies are closed, ignoring information on firm exports. We argue that this information is key to interpreting data and improving the accuracy of model predictions. To do this, we develop a dynamic model with export and domestic barriers. We show theoretically that the closed economy model underestimates barriers and amplifies counterfactuals. By calibrating the model to a set of European countries, we find that the quantitative difference is significant: for example, the closed economy model fails to see that Italian firms are very efficient exporters but poor innovators, and instead concludes that they are mediocre innovators. In terms of predictions, the closed economy model delivers an elasticity of welfare to innovation costs between 31 and 64 percent larger than the open economy model.
Correlates of zinc finger BED domain-containing protein 3 and ghrelin in metabolic syndrome patients with and without prediabetes
Authors: AbuZayed Rawan , Bulatova Nailya , Kasabri Violet , Suyagh Maysa , Halaseh Lana , AlAlawi Sundus
Published: January 2019

Background

Ghrelin and zinc finger BED domain-containing protein 3 (ZBED3) are distinctively cross linked with prediabetes (preDM) and metabolic syndrome (MetS).

Materials and methods

In a cross-sectional design with 29 normoglycemic MetS and 30 newly diagnosed drug naïve preDM/MetS patients vs. 29 lean and normoglycemic controls; ghrelin and ZBED3 were evaluated using colorimetric enzymatic assays.

Results

While ZBED3 mean circulating levels (ng/mL) in both MetS groups (normoglycemic and preDM) invariably lacked discrepancy vs. controls; Appreciably ghrelin levels (ng/mL) in preDM/MetS (but not normoglycemic MetS) participants were markedly higher vs. controls. Except for fasting plasma glucose (FPG) and glycosylated-hemoglobin (HbA1C); no further intergroup discrepancy could be identified between the MetS arms. Remarkably adiposity indices (body mass index (BMI), body adiposity index (BAI), and lipid accumulation product (LAP), but not conicity index (CI) or visceral adiposity index (VAI)); atherogenicity index of plasma (but not non-high-density lipoprotein-cholesterol (non-HDL-C/HDL-C) ratio, or total cholesterol (TC)/HDL-C ratio) or any of hematological indices (red cell distribution width (RDW-CV%), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR) and platelet (PLT) to lymphocyte ratio (PLR)) were substantially higher in both MetS (non- and preDM) groups vs. those of controls. Exceptionally low-density lipoprotein -cholesterol (LDL-C)/HDL-C ratio, and waist circumference (WC)/hip circumference (HC) ratio were much more pronounced in MetS-preDM vs. normoglycemic MetS recruits. In the MetS pool (both normoglycemic and preDM, n = 58), neither biomarker could relate to each other, or any of clinical parameters, adiposity or atherogenecity indices. Exceptionally ghrelin correlated significantly and inversely with age. ZBED3 correlated significantly and directly with RDW-CV% in the same pool of MetS recruits (n = 59).

Conclusions

Both biomarkers can not be ruled out as putative predictive/surrogate prognostic tools for metabolic anomalies prevention and pharmacotherapy.
Direct Thrust Inverse Control of Aero-Engine Based on Deep Neural Network
Authors: Zheng Qiangang , Du Ziyan , Fu Dawei , Hu Zhongzhi , Zhang Haibo
Published: January 2019

A novel thrust control method based on inverse control is proposed to improve engine response ability. The On Line Sliding Window Deep Neural Network (OL SW DNN) is proposed and adopted as inverse mapping model modeling method of inverse control. The OL SW DNN has deeper layer structure, which makes the inverse mapping model have stronger fitting capacity for nonlinear object than traditional NN. Moreover, due to adopt on-line learning modeling method, the proposed adaptive control method can obtain desired thrust whether engine degrades or not. The comparison simulations of the traditional control method based on PID and the proposed control method are carried out. Compared with the traditional control method, the proposed control method can obtain desired thrust when the engine degradation occurs, but also has fast response ability (the acceleration times for engine thrust increase to 95 % thrust of acceleration object decreases by 1.35 seconds).
Prefácio
Authors: Savone Riccardo
Published: January 2019

O presente texto propõe um prefácio ao Dossier : De 1867 à 2017 : Le Canada et ses processus de réinvention continue
De 1867 a 2017: o Canadá e as suas múltiplas reinvenções
Authors: Bernd Zilá , Balint Adina
Published: January 2019

Apresentação do dossiê De 1867 a 2017: o Canadá e as suas múltiplas reinvenções.
Transgressão e pioneirismo nos estudos canadenses: viagem por mais de 40 anos de carreira de Zilá Bernd
Authors: Berg Oscar Augusto
Published: January 2019

Entrevista com Zilá Bernd, realizada por Oscar Augusto Berg , em novembro de 2018, na ocasião da publicação de A persistência da memória (Besouro Box, 2018, 171 p.) e lançamento na 64ª Feira do Livro de Porto Alegre. A entrevista aborda a carreira da autora, especialista em estudos canadenses no Brasil, bem como a questão da francofonia na atualidade.
Editorial Vol. 18, n. 3 - Postcolonial and Intersectional studies. Multidimensional approaches and challenges for black women in Americas
Authors: Axt Gunter , Vandresen Monique , Cerqueira Fábio Vergara , Santos Eloína , Dos Santos Gislene
Published: January 2019

Editorial Vol. 18, n. 3 - Postcolonial and Intersectional studies. Multidimensional approaches and challenges for black women in Americas
Design, synthesis and characterization of bitumen emulsifiers based on molecular simulation
Authors: Kong Xiangjun , Zhao Junhe , Zhang Lijun , Liang Zupei , Wang Jinlan
Published: January 2019

Under the guidance of molecular simulation technology, the Monte Carlo molecular mechanics simulation was used to calculate the compatibility of different lipophilic groups with each component of bitumen, and the compatibility of different hydrophilic groups with water. Based on the calculated results of interaction parameters Chi and mixture energy Emix, the preferred structures of lipophilic and hydrophilic groups of bitumen emulsifier were determined. The target bitumen emulsifier was then synthesized by the reaction of organic acid and polyamine. The molecular simulation results showed that the compatibility of lipophilic group T11 with the bitumen was the best, and the mixing ability of the hydrophilic group H5 with water was excellent. The experimental results show that the preferred structures T11H5 had a good emulsifying performance to prepare emulsified bitumen with good storage stability, consistent with the results of the molecular simulation.
Medicinal and pesticidal potentials of the constituents of the essential oil from Adenia cissampeloides leaves
Authors: Ogunlesi Modupe , Okiei Wesley , Ofor Edith , Eniola Anthony
Published: January 2019

Adenia cissampeloides (Planch. ex Hook.) Harms is used in alternative medicine primarily for the management of hypertension
and several other diseases. Isolation and GC-MS analysis of five essential oils collected fractionally and over 4 h by hydrodistillation from the dried leaves were carried out. The constituents included phytol, α-linolenic acid, n-hexadecanoic acid, hexahydrofarnesyl acetone, (13S)-8,13-epoxy-labd-14-ene, kaur-16-ene, guaiol, α-gurjunene, and α-elemene. Several bioactivities
of the constituents as well as their potential applications in medicine and the pharmaceutical and pesticidal industries are discussed. Essential oils from some other plants have several constituents in common with those isolated from A. cissampeloides.
The bioactivities of such plants are used to suggest other possible applications of A. cissampeloides.
Stereokemija na drugi način
Authors: Molčanov Krešimir
Published: January 2019

U ovome se članku prikazuje sustavan pristup stereokemiji te tumačenju njezina središnjeg pojma, kiralnosti, jednostavnijim načinom koji se može prilagoditi nastavi kroz eksperimente. Polazeći od predmetâ iz svakodnevne uporabe (cipele, zrcala, puževi, itd.), dolazi se do općeg opisa kiralnosti, iz kojega se onda izvodi molekulska kiralnost. Tetraedarski se ugljikov atom može smatrati specijalnim slučajem, koji se može izvesti naknadno.
Routine orthostatic LVOT gradient assessment in patients with basal septal hypertrophy and LVOT flow acceleration at rest: please stand up
Authors: Sinclair H. C. , Russhard P. , Critoph C. H. , Steadman C. D.
Published: January 2019

A 70-year-old female with exertional dyspnoea was found to have basal septal hypertrophy (BSH), or a ‘basal septal bulge’, with evidence of mild left ventricular outflow tract obstruction (LVOT) at rest on her initial echocardiogram. She was usually fit and well with no significant past medical history. She had no history of hypertension. She had never smoked. There was no family history of hypertrophic cardiomyopathy (HCM). A cardiac MRI did not demonstrate any typical features of HCM. ECG showed sinus tachycardia with a rate of 101 bpm but was otherwise unremarkable. She was referred for exercise echocardiography to assess for latent LVOT obstruction. Prior to commencing exercise, her LVOT gradient was re-assessed at rest. Her LVOT gradients were 30 mmHg at rest, 49 mmHg during Valsalva and 91 mmHg on standing. A diagnosis of significant latent LVOT obstruction was made and the patient was started on bisoprolol, a cardioselective beta-blocker. Bisoprolol was slowly uptitrated from 1.25 mg to 5 mg once daily, following which the patient reported a significant improvement in her symptoms with an improved exercise capacity. Follow-up echocardiography demonstrated a dramatic reduction in LVOT gradient, with a maximum of 11 mmHg assessed both with Valsalva and on standing. This case is a reminder that patients with a ‘common’ basal septal bulge can develop significant LVOT obstruction, the symptoms of which may respond to pharmacological therapy. Orthostatic assessment of LVOT gradient using echocardiography should be considered during standard LVOT obstruction provocation manoeuvres such as a Valsalva.
Kad ugdymas nebūtų vienakojis: dvasingumas kaip svarbi dedamoji
Authors: Kontrimienė Simona
Published: January 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Straipsnyje atskleidžiama dvasingumo svarba akademiniame diskurse, kuriame raginama siekti mokslo ir dvasingumo sintezės atsisakant klaidingo epistemologinio žemėlapio ir ugdant išskirtines intelektines savybes, bendrai vadinamas dvasiniu intelektu (SQ). Pristatomos dvasingumo sampratos ugdymo moksle – čia dvasingumas dažnai implikuoja autentiškumą, transcendavimą ir susietumą arba kritinį požiūrį kaip atsvarą tradiciniam religingumui bei transracionalias patirtis. Aptariami dvasingumo ugdymo aukštojo mokslo institucijose būdai.
Using Participatory Action Research to Teach Community Practice in a Post-Truth Era
Authors: Christensen M. Candace , Trout Inci Yilmazli , Perez Beatrix
Published: January 2019

[full article, abstract in English; abstract in Lithuanian]

This project focuses on the learning experiences of master of social work students in an advanced community practice course. The primary pedagogical method for the class was participatory action research, specifically the photovoice method. The MSW students completed a photovoice project focused on campus sexual violence in which they recruited students, outside the class, as participants. As coursework, students generated reflection papers, responses to readings, and focus group notes. These artifacts constituted the data for this project. The data analysis included grounded theory methods and a focus on post-truth politics, from which three categories emerged: (a) supporting cultural competence, (b) facilitating self-awareness (c) and viewing truth as multifaceted.
How Language Defines “Learning”: A Classroom View
Authors: Wynhoff Olsen Allison
Published: January 2019

[full article, abstract in English; abstract in Lithuanian]

“Learning” is defined and constructed in classrooms as teachers and students interact through the use of language. As such, “learning” is situated language practices. Theories of socially- constructed uses of language and interactions provide foundation for this work. Through a microethnographic discourse analysis, the findings show a teacher and students constructing shared cultural models of “learning,” holding each other accountable to particular academic and pedagogical practices as well as uses of academic language. The teacher employed linguistic strategies to make visible and engage students in the academic language and “thinking” practices that counted as “learning.”
Romai pagrindinėje mokykloje: tarp selektyvios izoliacijos ir visiškos niveliacijos
Authors: Žemaitėlytė-Ivanavičė Ingrida
Published: January 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Straipsnyje pristatomas romų etninės grupės mokinių tapatumo mokyklos bendruomenei suvokimas ir raiška pagrindinės mokyklos kontekste. Svarstoma, kas yra tas romas mokinys pagrindinėje mokykloje? Ar tai, ką jis šiandien patiria mokykloje, turėtume manyti esant problema, ar per ilgą laiką pasiekto rezultato sėkme? Koks tapatumas formuojasi mokyklos bendruomenėje ir kokią įtaką daro elgesiui mokykloje? Ar galime šį procesą kontroliuoti ir ar turime tai daryti? Siekiant išsiaiškinti, kaip romai suvokia savo grupę, savo tapatumą, santykį su kita – mokyklos kultūra – ir to suvokimo raišką, pasitelktas etnografinis tyrimas. Mokiniai stebėti jų kasdienėje mokymosi ir bendravimo erdvėje – mokykloje.
Fetal renal cysts: prenatal diagnostics and interventional treatment
Authors: Arlauskienė Audronė , Bartkutė Karolina , Laužikienė Dalia
Published: January 2019

Background / objectiveFetal genitourinary tract anomalies are the most common anomalies diagnosed antenataly. Most fetal urinary tract abnormalities are well seen with ultrasound. Punctation and aspiration of fetal cyst are usually performed if there is a risk of damage for fetal vital organs. Biochemical analysis of cyst fluid for the detection of cyst origin is being used. In cases of isolated one kidney pathology fetal outcome is good. This clinical case demonstrates diagnostics, interventional treatment and outcome of fetal renal cyst.Key words: fetus, cyst, prenatal dignostics, interventional treatment.Vaisiaus inkstų cistiniai dariniai: prenatalinė diagnostika ir intervencinis gydymas
Įvadas / tikslasVaisiaus šlapimo takų raidos ydos yra dažniausiai diagnozuojamos lyginant su kitų sistemų raidos ydomis. Pagrindinis tyrimo metodas, padedantis nustatyti vaisiaus inkstų cistas, yra vaisiaus echoskopija. Vaisiaus inkstų cistos punktuojamos, kai atsiranda kitų organų pažeidimo grėsmė. Cistos kilmei patikslinti naudojamas punktato biocheminis ištyrimas. Prognozė vaisiui būna gera, esant izoliuotai vienpusei patologijai. Šis klinikinis atvejis iliustruoja vaisiaus inkstų cistos diagnostiką, intervencinį gydymą ir baigtį.Reikšminiai žodžiai: vaisius, cistiniai dariniai, prenatalinė diagnostika, intervencinis gydymas.
Chemoradiotherapy in the treatment of locally advanced cervical cancer
Authors: Daukantienė Lina , Valuckas Konstantinas Povilas , Aleknavičius Eduardas , Pipirienė-Želvienė Teresė
Published: January 2019

The purpose of this article is overview of currently available knowledge found in literature about the chemoradiation for locally advanced cervical cancer.Cervical cancer is the third most commonly diagnosed cancer and the fourth leading cause of cancer death in females worldwide. Despite the available prevention and early detection strategies, carcinoma of the uterine cervix is still diagnosed as locally advanced disease in a considerable proportion of patients. Standart treatment of locally advanced cervical cancer is cisplatin-based chemoradiation. Unfortunately, results of the treatment are not sufficient and cancer relapses are frequent. New cytostatics regimens either alone or in combination with cisplatin are searching as radiosensitizers with concurrent radiotherapy. Neoadjuvant/induction chemotherapy, adjuvant/consolidation chemotherapy strategies, molecular agents targeting critical pathways are under investigation in clinical trials to improve results of the treatment.The purpose of this article is overview of currently available knowledge found in literature about the chemoradiation for locally advanced cervical cancer.Key words: locally advanced cervical cancer, chemoradiation, adjuvant/consolidation chemotherapy, neoadjuvant/induction chemotherapy.Chemospindulinis vietiškai išplitusio gimdos kaklelio vėžio gydymas
Straipsnio tikslas – apžvelgti ir pateikti šiuo metu prieinamoje literatūroje sukauptas žinias apie konservatyvų chemospindulinį vietiškai išplitusio gimdos kaklelio vėžio gydymą.Gimdos kaklelio vėžys yra trečia dažniausiai pasaulyje nustatoma moterų vėžio forma ir ketvirta pagal dažnį moterų mirties nuo vėžio priežastis. Nepaisant profilaktikos priemonių bei patikros programos, nemaža dalis gimdos kaklelio vėžio atvejų nustatoma jau vietiškai išplitusios IIB–IVA stadijos. Šiuo metu vietiškai išplitusio gimdos kaklelio vėžio gydymo standartas – suderintas chemospindulinis gydymas cisplatinos pagrindu. Deja, gydymo rezultatai nėra patenkinami, atkryčio dažnis išlieka didelis. Siekiant geresnių gydymo rezultatų atlikta ir atliekama daug klinikinių tyrimų, spindulinio gydymo metu taikant naujus citostatikus ar jų derinius su cisplatina, tiriama neoadjuvantinės/indukcinės bei adjuvantinės/konsoliduojančios chemoterapijos reikšmė, „taikinių“ terapijos panaudojimo galimybė.Reikšminiai žodžiai: vietiškai išplitęs gimdos kaklelio vėžys, chemospindulinis gydymas, adjuvantinė/konsoliduojanti chemoterapija, neoadjuvantinė/indukcinė chemoterapija.
“Lithuanian Surgery”: change for the same purpose
Authors: Lunevičius Raimundas
Published: January 2019

„Lietuvos chirurgija“: permaina tam pačiam tikslui
Nėščiųjų ir pagimdžiusiųjų hemorojus ir išangės įplėša: paplitimas, rizikos veiksniai bei įtaka moters gyvenimo kokybei
Authors: Bužinskienė Diana , Drąsutienė Gražina , Poškus Tomas
Published: January 2019

Šio straipsnio tikslas – apžvelgti literatūrą, nagrinėjančią nėščiųjų hemorojaus ir išangės įplėšos paplitimą, priežastis, dažnį, rizikos veiksnius bei šių ligų įtaką moterų gyvenimo kokybei.Išangės ligos (hemorojus ir išangės įplėša) tiek nėštumo metu, tiek laikotarpiu po gimdymo yra dažna patologija, kuriai vis dar stinga tiek koloproktologų, tiek akušerių ginekologų dėmesio. Šiuo metu nėra tyrimų, kuriuose perspektyviuoju būdu nėštumo metu ir po gimdymo būtų vertinamas išangės ligų atsiradimas, nustatomi jų rizikos veiksniai. Labai svarbu ištirti ir įvertinti šių ligų paplitimą Lietuvoje ir rizikos veiksnius, jų ryšį su nėštumo ir gimdymo veiksniais, laiku šias ligas diagnozuoti ir gydyti bei atrasti priemonių, kaip jų išvengti, taip pagerinant moterų gyvenimo kokybę ne tik nėštumo ir gimdymo metu, bet ir laikotarpiu po gimdymo.Reikšminiai žodžiai: hemorojus, išangės įplėša, nėštumas, gimdymas, rizikos veiksniai, gyvenimo kokybė
Hemorrhoids and anal fissures during pregnancy and after childbirth: prevalence, risk factors and impact on women’s quality of lifeDiana Bužinskienė, Gražina Drąsutienė, Tomas Poškus
The aim of this study was to review the literature regarding the incidence, prevalence, risk factors of hemorrhoids and anal fissures during, before, and after pregnancy and their impact on the quality of life of women.Both hemorrhoids and anal fissures are common during and after pregnancy; however, they are frequently overlooked by both coloproctologists and gynecologists. There are no prospective cohort studies of perianal diseases during and after pregnancy with an emphasis on identifying the possible risk factors. Thus, it is important to identify the incidence and risk factors of perianal diseases in Lithuania and to find the factors of pregnancy and delivery that could be related to the occurrence or prevent the occurrence of these diseases. In this way, the possible areas of correction and intervention could be identified.Key words: hemorrhoids, anal fissure, pregnancy, delivery, risk factors, quality of life
Tiesiosios ir gaubtinės žarnos vėžys: ar įmanoma jo išvengti?
Authors: Escalante Ricardo
Published: January 2019

Colorectal cancer: is it possible to prevent it?Ricardo Escalante