bluuebunny/crossref_metadata_2025 huggingface dataset:
Intelligent Cybersecurity Services and Management: Concepts, AI-based Modeling, Research Issues and Directions
Authors: Sarker Iqbal H.
Published: October 2020

Artificial intelligence (AI) is one of the major technologies in this Fourth Industrial Revolution, which aims to function in an intelligent manner in various application domains, e.g., intelligent cybersecurity management. Popular AI techniques that include machine learning and deep learning methods, natural language processing, the concept of knowledge representation, and knowledge or rule-based expert systems, can be used to intelligently tackle today's diverse cybersecurity problems according to the needs. Based on these AI techniques, in this paper, we aim to present a comprehensive view on \textit{AI-driven cybersecurity} in terms of concepts, extracting security insights, and eventually security intelligence modeling that can play significant role to solve various cybersecurity tasks such as identifying malicious activities, predicting cyber-attacks, access control, intrusions or anomaly detection etc. Thus, the concept of AI-based security modeling could make the cybersecurity computing process more intelligent and automated than the traditional ones. Based on our study, finally, we highlight several \textit{research issues and future directions} within the area of AI-driven cybersecurity. Overall, the ultimate goal of this paper is to serve as a reference point and guidelines for the cybersecurity professionals as well as the researchers in this work domain, particularly from the technical point of view.
Case report - a cornea donor with a positive SARS-CoV-2 finding
Authors: Wille Diana , Heinzelmann rer. nat. Joana , Hofmann rer. nat. Nicola , Börgel Martin , Kehlen rer. nat. Astrid , Müller med. Anke , Viestenz Prof. Dr. med. Arne
Published: October 2020

The safety of the patient is the highest priority when providing a recipient with a tissue transplant. When screening a potential donor, the presence of infectious diseases is therefore also considered, which requires special attention in view of the current SARS-CoV-2 pandemic. Reliable test systems for the detection of the novel virus and its determination during all phases of infection are a prerequisite for a reliable statement on the risk of transmission of the virus through a corneal transplant. The case of a 70-year-old cornea donor with a positive SARS-CoV-2 result, which is documented here, demonstrates the difficulty of a meaningful donor test.
Innovations as a Factor for Economic Growth and Labor Market Development
Authors: Raychev S. , Dimitrova G. , Madzhurova B. , Stoyanova D.
Published: October 2020

This paper summarises the arguments and counterarguments within the scientific discussion on the effects of R&D investment on the essential components of the economic development such as economic growth, competitiveness, labour market and inequality reduction. The main purpose of the research is to highlight the position of Bulgaria in the world economy concerning R&D development. In the article frame, the authors compared the R&D expenditures dynamics of Bulgaria and the EU28 by the prism of innovations in business and higher education. Systematisation literary sources and approaches for solving the problem indicated that R&D caused the changes in the job market that led to the necessity to adjust the university system. There is currently a lag. Methodological tools of this research were as follows: the method of processing quantitative data, content and comparative analyses, situational and sectoral analyses, and graphical dynamic analysis. The object of research is the dynamics of investments in innovations in Bulgaria and EU28. The emphasis is placed on the role of research centres, enterprises, clusters and education institutions in R&D development to assess the level of innovation achieved through R&D. The obtained results of an empirical analysis showed that the cluster approach raised R&D to a new level and helped to bring universities and business together. Rethinking of the public policies and investing in technology centres will help for the adaptation to the new realities of the labour market. The research results could be useful for employers, high tech research centres and universities. This study is expected to be the base for further studies dedicated to boosting economic competitiveness and social welfare due to the promoting implementation of innovations. Keywords competitiveness, economic growth, inequality, innovation, labour market, Research and development (R&D).
Consumer Innovativeness: a Literature Review
Authors: Eryigit Canan
Published: October 2020

This paper reports the results of a systematic review of recent literature on consumer innovativeness. The main purpose of the research is to identify the current research themes, understand emerging themes, and predict future directions in consumer innovativeness research. Previous reviews were either narrowly scoped or needed to be updated. Accordingly, the current literature review may fill this gap in the literature. The study sample is 188 articles published in journals indexed in the Web of Science database in the last decade. Content analysis was employed by using quantitative and narrative approaches. Based on the content analysis, these articles were assigned to five research themes as follows: 1) consequences of consumer innovativeness; 2) antecedents of consumer innovativeness; 3) the moderating role of consumer innovativeness; 4) the mediating role of consumer innovativeness; 5) measurement of consumer innovativeness. The findings showed that the highest proportion of articles reviewed in this study involve research that examines the consequences of consumer innovativeness. New product adoption is the most commonly identified consequence of consumer innovativeness. The next most common research themes were the moderator role and antecedents of consumer innovativeness. Articles in the measurement of consumer innovativeness were relatively rare. The fewer number of articles in the research theme indicates that measurement of consumer innovativeness has been well identified in the previous studies. The mediator role of consumer innovativeness was not common in the last decade. The research themes were examined in detail by providing the variables included in the previous studies and the study findings, as well. The research confirms the crucial role of consumer innovativeness in adoption. Besides, the findings indicated the augmented role of consumer innovativeness in consumer behaviour literature. The results of the research can be useful for guiding future research.

Keywords
antecedents of consumer innovativeness, consumer innovativeness, content analysis systematic literature review, consequences of consumer innovativeness.
Determinants to Provide the Efficiency of Integrated Development of the Light Industry Enterprises
Authors: Reshetnikova Iryna , Shvydanenko Henefa , Boichenko Kateryna
Published: October 2020

This article generalizes the arguments and counterarguments within the scientific discourse concerning the problems of integrated development of enterprises in the modern market economy. The main purpose of the research conducted is to create a methodological approach to the assessment and improvement of the integrated development efficiency of the Ukrainian light industry enterprises on the grounds of key determinants identification. For ensuring an extensive and systematic approach in this study, a three-step methodological base has been adopted. The interpretation and synthesis of high-quality data through sifting and sorting materials on key issues and subject matter of enterprise development in the context of integration have been conducted. The tendencies of development of the Ukrainian light industry enterprises have been analyzed to identify the key determinants. An assessment of their impact on the performance of integrated enterprise development has been made. The conducted research used the dialectical, structural and analytical as well as structural and functional analysis as a methodological tool. Methods for multicriteria analysis were used to determine the impact of the identified determinants, in particular, the calculation of the multivariate utility function and the normalization of determining factors. The article shows the results of the analysis of the light industry enterprises development with the help of such key determinants as providing of their own raw materials, availability of specialized mechanical engineering, repair base, properly qualified personnel, operating enterprises development. The integrated development of fifteen light industry enterprises has been diagnosed with the help of such main determinants as financial and resource support, intellectual and innovative potential, economic security, risk level, self-integration, the synergistic effect of integrated business processes. A group of enterprises has been identified, which the development level in the context of its integration is lower than estimated by the methods of classical performance diagnostics at the present stage. The group of enterprises has been identified, where integration processes are effective and have prospects for development. It is established that the integrated development implementation, due account being taken of the full complex of its determinants will promote greater usefulness and efficiency of the studied light industry enterprises functioning. The results of the conducted study can be useful for the efficiency improvement of domestic enterprises based on the integration

Keywords
efficiency, integrated development, utility, model, factor.
Olympic Games as a Digital Media Product
Authors: Yan Wang
Published: October 2020

This paper studies the development of economic ties between professional sports and media in the past ten years by the example of the Olympic Games media coverage. The main purpose of the research is to identify the regularities that are formed in the communicative environment of elite sports. The paper is focused on the Olympic Games as the global sports events that include several types of sports competitions. The subject of the study is the sport as a product. The object of the study is the sport entertainment products in the media sphere. The relevance of the research is that the interconnections between sports and media expand and change rapidly and are influenced not only by the development of new technologies but also by a coronavirus situation. The systematization of literary sources on the selected matter indicated the need for further studies to reflect the rampant evolution of sports media and the lack of unified terminology for viewing professional sports through the prism of mass media as a media product. The methodology of the research is based on the analysis of open-source statistical data and a set of empirical materials (official websites of sports organizations, TV channels, and social media pages). The author viewed these materials from four perspectives: the audience, the marketing approach, the sports themselves as a source of information, the mainstream and the new media. The results allowed identifying the main trends of the information space formation around the object under study. These trends prove that the structure of the «Elite Sports» media product is becoming more complex, and the number of communicative links and broadcasting opportunities of sports events has increased. Finally, the author proposed a conceptual model of representing professional sports as a media product on the example of the major sports events, through defining its communication links. The findings of the research could be useful for setting vectors for studying mainstream and new media in the chosen area. The study can be of interest to sports journalists, bloggers, managers, and officials.

Keywords
audience, communication, content distribution, professional sports, sports event.
Innovation management in education: impact on socio-labour relations in the national economy
Authors: Vorontsova Anna , Mayboroda Tetyana , Lieonov Hlib
Published: October 2020

Education plays an essential role in the national economy and is responsible for the formation of qualified and competent human resources that will act in the labour market as a labour force. At the same time, in the conditions of rapid acceleration of socio-cultural and scientific-technical changes, the updating of knowledge and acquired competencies becomes compulsory today. Therefore, there is an unconditional connection between the sphere of socio-labour relations and the field of education. Despite this, today in Ukraine there is an imbalance between these areas, which are oversaturation of the labour market by some professionals (including economic and legal), and lack of others (including labour professions), labour migration, the dissatisfaction of employers with the level of knowledge of graduates, etc. It requires the modernization of the existing situation and the coordination at the state level of the areas of interaction between socio-labour relations and education sector. In this regard, this article is devoted to the justification of the impact of state regulation of education on the development of socio-labour relations in the national economy, which will be carried out by combining the method of principal components and logit modelling in the software STATA 11. To identify the integrated level characterizing the state of socio-labour relations in the national economy of Ukraine, numerous absolute and relative indicators were analyzed, including unemployment and employment levels, labour productivity, wage arrears and its average level, etc. The results obtained suggest an improvement in the socio-labour relations in Ukraine in recent years. Logit modelling allows confirming, as well as comprehensively and individually, the impact of macroeconomic, demographic, migration parameters, and a set of performance characteristics of the education sector on the level of harmonization and convergence of processes in labour markets and educational services. It helps to define the priorities of state intervention in the field of state regulation of education. The set calculations form the basis of further research of authors in the field of the specified problems. Keywords state regulation of education, socio-labour relations, national economy, labour market, binary logit modelling.
Stakeholders of Green Competitiveness: Innovative Approaches for Creating Communicative System
Authors: Chygryn Olena , Bilan Yurii , Kwilinski Aleksy
Published: October 2020

The issue of stakeholder activity and collaboration for developing and promoting the green competitiveness of enterprises are nowadays relevant and play a significant role in creating competitive advantages. Systematization literary sources prove that economic activity is characterizing by specific relationships between a wide set of stakeholders, the effective communicative system can bring potential benefits to all parties and stakeholders have specific expectations regarding various aspects of the enterprises’ operation: organizational, economic, social, environmental etc. The main objective of the article is creating the preconditions for building the stakeholder communication system for promoting the green competitiveness of the company and assessing by stakeholders the results of companies’ activity. The paper used scientific methods are based on logical generalization and scientific abstraction for systematizing the prerequisites for the formation of a system of communications of green competitive stakeholders; typology of green competitiveness stakeholders; formal-logical for determining the determinants and principles of effective collaboration of stakeholders of green competitiveness. For investigating the stakeholders’ assessment of the green competitiveness effects was undertaken Multidimensional scaling analysis and were estimated five outcome dimensions: consumer satisfaction in green goods; efficiency of green goods production; green goods quality and cleaner production; institutional partnership; community impact. For scaling responses in survey research was used a seven-point psychometric Likert scale. A general questioning is provided for five countries: Ukraine, Poland, Romania, Slovenia, Czech Republic, and include the results of the survey the 1236 stakeholders. The results of the assessment showed that in all groups (internal and external) of stakeholder, the employees assessed results of the environmental strategies as «success» – 22,3% and community from another group – 7,45%. The stakeholder opinion is the same. That is evidence that the processes of greening stakeholder’s communication are becoming wider and involve more participants. The result of the research creates the background for improving the system of green competitiveness stakeholder interaction. Keywords stakeholder, green competitiveness, interaction, stakeholder partnership, assessment.
Hydrogen peroxide-assisted photocatalytic water treatment for the removal of anthropogenic trace substances from the effluent of wastewater treatment plants
Authors: Schnabel Tobias , Mehling Simon , Londong Jörg , Springer Christian
Published: October 2020

Supported titanium dioxide catalysts were used in a photocatalytic flat cell reactor to remove organic micropollutants from real wastewater. Catalysts based on stainless steel mesh with a porous coating made of titanium dioxide nanoparticles with predominantly anatase modification were used. The influence of the retention time, and light output, and the effect of hydrogen peroxide on the degradation were examined. The kinetics of the degradation of the parent substances was determined by liquid chromatography-tandem mass spectrometry. As a result, first-order degradation kinetics could be confirmed for all substances. The irradiance had no linear influence on the degradation of the compounds. Hydrogen peroxides were added to the wastewater to be treated, as electron acceptors and boosters, and alone had no great oxidative effect on the parent substances. The combination of photocatalysis with the addition of hydrogen peroxide as an electron acceptor had great synergetic effects which can reduce the required energy of the process through a short retention time. The process is suitable for the removal of micropollutants from wastewater.
Violencia de género y trastorno de estrés postraumático en mujeres peruanas
Authors: Saquinaula-Salgado Milagros , Castillo-Saavedra Ericson Felix , Rosales Márquez Cinthia
Published: October 2020

Se realizó un estudio descriptivo correlacional de corte transversal, que planteó determinar la asociación entre la violencia de género y el trastorno de estrés postraumático en mujeres peruanas. La muestra estuvo constituida por 105 mujeres que se atendieron en la División de Medicina Legal II de la provincia del Santa (Perú). Para recolección de la información se utilizaron dos instrumentos que fueron sometidos a validez y confiabilidad, la violencia de género se midió mediante un cuestionario constituido por 20 ítems, y el trastorno por estrés postraumático por un cuestionario de 16 ítems. Los resultados evidencian que el 56,2% de mujeres agredidas presentan violencia leve y el 61,9% no presentan síntomas de trastorno de estrés postraumático. Finalmente, se encontró alta asociación significativa entre la violencia de género y los trastornos de estrés postraumático.
Estilo de vida en pacientes con Diabetes Mellitus tipo II de una institución de salud en Santa Marta, Colombia, 2017
Authors: Rivas-Castro Aneth , Leguísamo-Peñate Irene , Puello-Viloria Yamile
Published: October 2020

Determinar el estilo de vida de los pacientes con diabetes mellitus tipo II de una institución de salud en la ciudad de santa marta. Estudio cuantitativo, descriptivo y transversal. Se describe la variable estilo de vida medido a través de siete dominios: nutrición, actividad física, consumo de tabaco, consumo de alcohol, información sobre diabetes, emociones y adherencia terapéutica, la muestra estuvo representada por 105 pacientes, que asistían a control en una institución de primer nivel de atención. Se evidencia que el 53% son mujeres, los pacientes se encuentran en edades de 18-35 años (9%), 36-59 años (44%) y mayor de 60 años (47%). El 55% de los pacientes manifiesta inadecuado estilo de vida, establecido esto por el consumo de alcohol (10%), algunos fuman (5%), y otros consumen alimentos entre comidas (60%); además refieren autoestima de media a baja, a la vez el 75% refiere buena adherencia al tratamiento. Los participantes de este estudio a pesar de tener conductas de responsabilidad de su salud, aún tienen conductas que modificar relacionados con el alcohol, cigarrillo y la nutrición como dominio predominante; esto es lo que determina un estilo de vida inadecuado.
Enfermería: una profesión de liderazgo
Authors: Cortina Navarro Carolina Elena , Oviedo-Cordoba Haidy Rocio
Published: October 2020

Las organizaciones que se encuentran vinculadas al sector de la salud, constantemente están expuestas a cambios que se asocian al contexto social, demográfico, epidemiológico y tecnológico, son en los cuales se inserta.
Enkomion mądrości i jego funkcja perswazyjna w Księdze Mądrości
Authors: Muszytowska Dorota
Published: October 2020

Księga Mądrości uznawana jest za spójny tekst charakteryzujący się synkretyzmem gatunkowym. Celem niniejszego artykułu jest przebadanie zawartej w Księdze Mądrości pochwały mądrości pod kątem jej perswazyjnych funkcji w utworze. Do badań wykorzystano enkomion jako gatunek typowy dla retoryki epideiktycznej. Tekst pochwały został przeanalizowany z perspektywy cech wyróżniających ten gatunek i decydujących o jego bazowej strukturze. Analizy doprowadziły do wniosku, że autor wykorzystał możliwości gatunku, aby pouczyć odbiorców o jaką mądrość powinni zabiegać i by skłonić ich do podjęcia działań zmierzających do jej osiągnięcia. Enkomion w Księdze Mądrości został podporządkowany retoryce doradczej i stanowi ważny element w strukturze utworu.
Efficacy of Six Plants of Apiaceae Family for Body Weight Management: A Review from the Perspective of Modern and Traditional Persian Medicine
Authors: Rameshk Maryam , Kalantari-Khandani Shahram
Published: October 2020

Background::

Obesity is a common health concern among all populations and age groups worldwide and is a risk
factor that leads to a significant increase in mortality and cardiovascular diseases, type 2 diabetes, metabolic syndrome,
stroke, and cancer. Disappointing results and weight regain after stopping lifestyle modification or drug therapy indicate the
need for other methods of treatment to achieve better and longer effective results.

Objective:

In this study, the effect of the Apiaceae plants, including Carum carvi L., Bunium persicum Boiss., Cuminum
cyminum L., Anethum graveolens L., Foeniculum Vulgare Mill. and Trachyspermum ammi L., in the TPM to treat obesity,
were compared to modern database covering all in vivo and clinical trials on animal models or humans.

Method:

In TPM sources, we used the keywords, "Saman-e- Mufrat", "Hazāl", and "Mohazzel”. Each of the six plants were
searched in the electronic databases, including Pubmed, Scopus, and Embase from 1975 to 1/1/2020 using keywords, namely
"body mass", "body weight" and "obesity".

Results:

The results indicated that six plants had reducing effects on body weight, BMI, fat mass, and appetite in almost all
clinical studies on humans and some studies on animals.

Conclusion:

Since the TPM is a rich source of information about the medicinal properties and effects of medicinal plants,
investigating the therapeutic effects of plants from the perspective of TPM can represents the vision of a new horizon in the
treatment of many diseases.
Elachi Lemon (Citrus limon) Peel and Pulp: Antioxidant, Antimicrobial, Anticoagulant Activities, Bioactive Compounds, Minerals, and Heavy Metals
Authors: Khandker Shahad Saif , Kabir Alamgir , Hasan Md. Jahid , Ahmed Md. Shohael , Gan Siew Hua , Khalil Md. Ibrahim , Islam Md Asiful , Hossan Tareq , Kamal Mohammad Amjad
Published: October 2020

Background:

According to a number of previous studies, citrus fruits are rich in phytochemicals,
minerals and bioactive compounds.

Objective:

The aim of this study was to investigate the antioxidant, antimicrobial and anticoagulant
activities, phytonutrients, bioactive compounds, mineral and heavy metals in the peel and pulp of
Elachi lemon (Citrus limon).

Methods:

Phytochemical screening was performed to estimate the total polyphenol, flavonoid, tannin,
reducing sugar, total protein and vitamin C contents. High performance liquid chromatography
was performed to determine the concentrations of phenolics and ascorbic acid. Antioxidant activities
were evaluated by measuring 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity,
reducing power assay and ferric reducing antioxidant power (FRAP) assay. Antibacterial activity
was evaluated by the disc diffusion method and minimum inhibitory concentration (MIC).
Besides estimating heavy metals and minerals, activated partial thromboplastin time (aPTT) and
prothrombin time (PT) were observed for detecting anticoagulant activity.

Results:

In the case of antioxidant and antimicrobial activities, the pulp was found to be richer.
Both the peel and pulp showed similar anticoagulant activities. Among the phytonutrients, protein
content was richer in the peel than in the pulp. Catechin, rutin, tannic, gallic and vanillic acids were
detected in the peel, whereas in pulp quercetin, tannic and gallic acids were found. Pb, Cr, Cd were
present in a negligible amount whereas, Co, Cu and Fe were high in both the peel and the pulp.

Conclusion:

This study exhibits that both the peel and the pulp of Citrus limon are a rich source of
antioxidant, antimicrobial, anticoagulant, minerals and various bioactive compounds with nutritional
values.
Does Metformin Satisfy as an Option for Host-Directed Therapy in COVID-19?
Authors: Thangaraju Pugazhenthan , Jindal Atul , Venkatesan Sajitha , Gurunthalingam Meenalotchini P. , Venkatesan Nanditha , Thangaraju Eswaran
Published: October 2020

Metformin is a dimethyl biguanide known for its anti-hyperglycemic effects since 1922
and, thus, has been used in the treatment of Type 2 Diabetes Mellitus. Apart from this, its function
as an anti-inflammatory, anti-oxidant, anti-thrombotic, and anti-microbial agent has also been
studied largely. Its effect via inhibition of respiratory complex 1 and glycerol-3-phosphate dehydrogenase
(GPD2) in the mitochondria and inhibition of the mammalian target of rapamycin complex
1 (mTORC1) and activation of Adenosine Mono Phosphate dependent kinase (AMPK) in the cytoplasm
are its already known mechanisms of action. With the newer proposed effects on endosome/
lysosome regulation via Na+/H+ exchangers and V-ATPase, thereby affecting autophagy,
coupled with its use in ARDS owing to its immunomodulatory effects and anti-viral action, the use
of metformin against the novel Coronavirus is hypothesized.
Lessons Learnt from a National Competition on Structural Optimization and Additive Manufacturing
Authors: Xiong Yulin , Bao Dingwen , Yan Xin , Xu Tao , Xie Yi Min
Published: October 2020

Background::

As an advanced design technique, topology optimization has received
much attention over the past three decades. Topology optimization aims at finding an optimal material
distribution in order to maximize the structural performance while satisfying certain constraints.
It is a useful tool for the conceptional design. At the same time, additive manufacturing technologies
have provided unprecedented opportunities to fabricate intricate shapes generated by topology optimization.

Objective::

To design a highly efficient structure using topology optimization and to fabricate it using
additive manufacturing.

Method::

The bi-directional evolutionary structural optimization (BESO) technique provides the
conceptional design, and the topology-optimized result is post-processed to obtain smooth structural
boundaries.

Results::

We have achieved a highly efficient and elegant structural design which won the first prize
in a national competition in China on design optimization and additive manufacturing.

Conclusion::

In this paper, we present an effective topology optimization approach to maximize the
structural load-bearing capacity and establish a procedure to achieve efficient and elegant structural
designs.

:

In the loading test of the final competition, our design carried the highest loading and won the first
prize in the competition, which demonstrates the capability of BESO in engineering applications.
A CMT Device for Electrical Energy Meter Detection
Authors: Zeng Zhi , Zhou Yongfu
Published: October 2020

Background:

Detection technology is a product development technique that serves as a basis for quality assurance. As electric energy meters (EEMs) are measurement instruments whose use is mandatory in several nations, their accuracy, which directly depends on their reliability and proper functioning, is paramount. In this study, to eliminate electromagnetic interference, a device is developed for testing a set of EEMs under a constant magnetic field interference. The detection device can simultaneously test 6 electric meters; moreover, in the future, it will be able to measure the influence of magnetic field strength on the measurement accuracy of EEMs, thereby improving the production efficiency of electric meter manufacturers.

Methods:

In this study, we first design a 3D model of the detection device for a single meter component; then, we establish a network, which includes a control system, and perform the planning of the path of a block that generates a constant magnetic field. Finally, we control the three-axis motion and rotation of the block using a PLC to implement detection for the five sides of the EEM.

Results & Discussion:

The proposed device can accurately determine whether an EEM can adequately function, within the error range prescribed by a national standard, under electromagnetic interference; this can enable reliable, automatic testing and fault detection for EEMs. Experiments show that our device can decrease the labor cost for EEM manufacturers.
Coronavirus Disease 2019 (COVID-19): Current Situation and Therapeutic Options
Authors: Singh Veer , Mishra Vishal
Published: October 2020

Coronavirus disease 2019 (COVID-19) is defined as an illness caused by SARS-CoV-2 (severe
acute respiratory syndrome coronavirus 2). COVID-19 was first reported in the Wuhan, China, in
late December, 2019. The World Health Organization (WHO) declared COVID-19 a global emergency
on March 11, 2020. COVID-19 was rapidly transmitted and caused infection in 21,294,845 people and
761,779 deaths in more than 213 countries worldwide till August 16, 2020. United States of America
(USA), Brazil, India, Russia Federation, Peru, Mexico, Colombia, Spain, France, Italy, Germany, and
United Kingdom (UK) stand top COVID-19 affected countries in the world. The high transmission rate
of COVID-19 might be due to large viral incubation time (2-14 days) and some modifications in the
spike glycoprotein. Currently, effective drugs or vaccines are not developed for the treatment of novel
coronavirus. However, few antibiotics like hydroxychloroquine and remdesivir have been currently used
for the treatment of COVID-19 infection. Several collaboratives are working together for developing an
effective and safe vaccine against COVID-19 and few vaccines are under clinical trial. Scientists are
also working on plasma therapy and monoclonal antibodies. Nowadays, plasma therapy is considered
the most effective treatment against COVID-19 and some promising results have been achieved. This
review focuses on several therapeutic options for COVID-19, such as anti-viral drugs, vaccines, plasma
therapy, and monoclonal antibodies. This review also covers the current situations of COVID-19 in the
world. This review is about COVID-19, which will be beneficial to researchers for the development of
potential treatment against it.
COVID-19 Epigenetics and Implications for Public Health
Authors: Tunaligil Verda , Meral Gülsen , Kati Ahmet , Chattopadhyay Dhrubajyoti , Mandal Amit Kumar
Published: October 2020

Background:

COVID-19 debilitated communities globally in varying complexities and capacities
in recent months.

Objective:

The epigenetic changes in the COVID-19 patients were discussed in this article to explore various
processes contributing to disease severity and elevation of risk due to infection.

Result & Conclusion:

The COVID-19 disease is observed to be the most severe in the 65 and-higher-age
group with pre-existing chronic conditions. This observational study is a nonexperimental empirical investigation
of the outcomes of COVID-19 in different patient groups. Results are promising for conducting clinical
trials with intervention groups. To ultimately succeed in disease prevention, researchers and clinicians must
integrate epigenetic mechanisms to generate valid prescriptions for global well-being.

Methods:

Percentages of hospitalization, with and without intensive care, in the presence of diseases with increased
ACE2 expression, were compared, based on the best available data. Further analysis compared two
different age groups, 19-64 and ≥65 years of age.
Comparison of Snail-1 and Estrogen Receptor Immunoexpression between Fibroadenomas and Phyllodes Tumors
Authors: Quzwain Fairuz
Published: October 2020

Fibroadenomas (FA) and phyllodes tumors (PT) are fibroepithelial lesions in the breast, which until now the relationship between the pathogenesis of both have not been ascertained yet. Epithelial cells are thought to be involved in the regulation of changes in the stromal cells in the PT, so it can be estimated that this process is involved in epithelial-mesenchymal transition (EMT). This study aims to compare of snail family transcriptional repressor 1 (Snail-1) and estrogen receptor (ER) impression as EMT factors among tumor typeÂ  (FA, benign PT, boderline PT and malignant PT). This study was an observational analysis with the cross-sectional method. After the histologic grade of the samples was reviewed, immunohistochemistry examination for ER and Snail-1 was performed. Statistical analysis for categorical data was tested by chi-square test. There were 66 samples, consists of 20 FA, 17 benign PT, 16 borderlines PT, and 13 malignant PT. A significant difference in the loss of ER expression in borderline and malignant PT was found compared to FA and benign PT. This is inversely proportional to the snail-1 expression, where the expression was high in borderline PT and malignant PT stromal cells. This could support the consideration of the pathomechanism regulation of epithelial-mesenchymal cell transition changes in FA with PT, where Snail-1 is one of the proteins in the regulation of the EMT and RE processes acting as an inhibiting factor in transcription factors in the mechanism of EMT occurrence.
КОРОНАВІРУСНА ХВОРОБА (COVID-19): ОСОБЛИВОСТІ ПЕРЕБІГУ ТА ЛІКУВАННЯ ІНФАРКТА МІОКАРДА І СЕРЦЕВОІ НЕДОСТАТНОСТІ
Authors: Середюк Н. М. , Середюк В. Н. , Скакун О. З. , Ванджура Я. Л. , Твердохліб І. З.
Published: October 2020

Резюме. З моменту виявлення коронавірусу SARS-CoV-2 надзвичайно швидко розповсюдився світом, викликавши глобальну пандемію. Одним із найпоширеніших ускладнень коронавірусної хвороби є пневмонія, однак SARS-CoV-2 уражає також міокард, головний мозок, нирки, печінку тощо. Надзвичайно актуальними питаннями є перебіг інфаркта міокарда та хронічної серцевої недостатності при коронавірусній хворобі. У проникненні вірусу в клітину важливу роль відіграють АПФ-2, трансмембранна серинова протеаза TMPRSS2 та фурин. У пацієнтів із серцевою недостатністю рівень АПФ-2 є підвищеним, тож це з одного боку може сприяти проникненню SARS-CoV-2 всередину клітини, а з іншого боку – АПФ-2 може мати протективний ефект, оскільки він перетворює ангіотензин 1 в ангіотензин (1-9), а ангіотензин 2 в ангіотензин 1-7, який функціонує як антагоніст ренін-ангіотензин-альдостеронової системи (вазодилатація, посилення діурезу). Для підтвердження пошкодження міокарда за наявності COVID-19 використовують серцеві біомаркери (головним чином серцевий тропонін), а для визначення наявності серцевої недостатності – NT-proBNP. Пошкодження міокарда може проявлятися як порушеннями ритму та провідності, так і виникненням гострої серцевої недостатності та інфаркту міокарда. Для діагностики цих станів використовують визначення тропоніну І, електрокардіографію, ехокардіографію, МРТ серця з контрастуванням, коронароангіографію. Для усіх госпіталізованих пацієнтів рекомендовані низькомолекулярні гепарини на період госпіталізації. Для пацієнтів з високим ризиком венозних тромбоемболій та низьким ризиком кровотеч можна розглянути прийом НОАК або еноксапарину тривалістю до 45 днів з моменту виписки.
ОРГАНІЗАЦІЯ ДИСТАНЦІЙНОГО НАВЧАЛЬНОГО ПРОЦЕСУ НА КАФЕДРІ ДЕРМАТОЛОГІЇ ТА ВЕНЕРОЛОГІЇ ІФНМУ В УМОВАХ ПАНДЕМІЇ 2019-NCOV
Authors: Волошинович М. С. , Сенчій В. М. , Александрук О. Д. , Ткач В. Є. , Гірник Г. Є. , Матковська Н. Р.
Published: October 2020

Резюме. Спалах коронавірусної інфекції зруйнував нормальний ритм життя по всьому світу. Станом на сьогодні передбачити в повній мірі наслідки впливу пандемії на сектор навчання і в тому числі вищої освіти неможливо. У першу чергу це пов’язано з тим, що ситуація все ще розгортається, а безпосередні впливи нашаровуються на соціальні, психологічні, економічні та інші фактори суспільного середовища.

В умовах пандемії, що триває, набули нового значення і стали вирішенням більшості освітніх проблем механізми дистанційного навчання. Вони залишились єдиним доступним методом донесення знань в умовах збереження достатньої відстані поміж учасниками навчального процесу.

Для його організації варто покладатись на комплексні програмні рішення такі як платформа Teams. На кафедрі Дерматології та венерології дистанційна форма була застосована як для до дипломного, так і післядипломного навчання. Згідно з попередньо узгодженими графіками проводились щоденні відеоконсультації; для відповіді на дискутабельні запитання дисципліни, начитка лекційного матеріалу; завдання студенти отримували у вигляді тестів та клінічних задач.

Проте системі не вистачає можливостей до проведення опитувань під час лекцій з відображенням результатів голосування в реальному часі. Цю, необхідну функцію, а в умовах віддаленої освіти, і механізм для перевірки участі респондентів у засвоєнні матеріалу, можна реалізувати залученням сторонніх додатків, наприклад Mentimeter.

Застосування платформи сприяє збільшенню зацікавленості студентів навчальним матеріалом, забезпечує механізм перевірки активної участі респондентів у дискусії та отримання зворотного відклику. Проте важливим є не розгубити позитивні моменти старої моделі навчання, формуючи новий напрямок.
ЗМІНИ ФУНКЦІОНАЛЬНИХ ПАРАМЕТРІВ ЗОВНІШНЬОГО ДИХАННЯ У ЧОЛОВІКІВ З ОЖИРІННЯМ В ПРОЦЕСІ ФІЗИЧНОЇ ТЕРАПІЇ ЯК МАРКЕР ЕФЕКТИВНОСТІ ЕЛЕМЕНТІВ РЕСПІРАТОРНОЇ РЕАБІЛІТАЦІЇ
Authors: Аравіцька М. Г.
Published: October 2020

Резюме. Цілі: визначення зміни параметрів функціонування дихальної системи у чоловіків з ожирінням під впливом засобів респіраторної реабілітації в рамках комплексної програми фізичної терапії.

Методи. Обстежено 116 чоловіків з аліментарно-конституціональним ожирінням І-ІІІ ступеня. За результатами визначення реабілітаційного альянсу їх було поділено на дві групи. Групу порівняння склали особи з низьким рівнем альянсу. Основну групу склали особи з високим рівнем альянсу, які проходили річну програму корекції із застосуванням заходів для підтримки альянсу, модифікації харчування, збільшення фізичної активності, лімфодренажу, психокорекції, елементів респіраторної терапії. Контрольну групу склав 31 чоловік з нормальною масою тіла. Досліджували суб’єктивний стан, інтенсивність задишки, параметри пульсоксиметрії, спірометрії.

Результати. У чоловіків з ожирінням виявлена дисфункціїя дихальної системи: суб'єктивні ознаки порушення дихальної функції, задишка, зменшення оксигенації артеріальної крові, зниження дихальних об'ємів. Їх  зміст та ступінь вираженості були пропорційною важкості ожиріння. Застосування елементів респіраторної терапії в рамках програми комплексної фізичної терапії, спрямованої на зменшення маси тіла, дозволило нормалізувати досліджувані параметри функції дихальної системи. Низький рівень реабілітаційного альянсу призвів до незадовільного виконання наданих рекомендації та асоціювався із відсутністю реабілітаційного ефекту.

Висновки. Елементи респіраторної реабілітації патогенетично доцільно включати до схем відновлення стану здоров'я пацієнтів з ожирінням, особливо при високих його ступенях або супутніх захворюваннях.

Ключові слова: жирова тканина, бронхолегенева система, корекція.
From the Editor, September 2010
Authors: Stark Ernie
Published: October 2020

A letter from the editor.
Merger Repair: A Conceptual Framework for Restoring Employer/Employee Relationships
Authors: Galpin Timothy , Whittington J. Lee
Published: October 2020

During mergers and acquisitions a variety of integration management transgressions - both intentional and unintentional - occur. If these are not addressed, there will be a severe and potentially permanent damage to the relationship between the organization and its employees. This area of study has been identified as lacking sufficient examination and is ripe for future work (Haleblian, Devers, McNamara, Carpenter, & Davison, 2009). In this paper, we identify the common sources of these integration transgressions. Drawing on research based in social psychology and merger integration, we develop the construct of merger repair. We also identify several techniques for repairing the damaged relationships. Implications for practitioners and propositions to guide future research are developed.
Low Testosterone on Social Media: Application of Natural Language Processing to Understand Patients’ Perceptions of Hypogonadism and Its Treatment
Authors: Osadchiy Vadim , Jiang Tommy , Mills Jesse Nelson , Eleswarapu Sriram Venkata
Published: October 2020

Background

Despite the results of the Testosterone Trials, physicians remain uncomfortable treating men with hypogonadism. Discouraged, men increasingly turn to social media to discuss medical concerns.

Objective

The goal of the research was to apply natural language processing (NLP) techniques to social media posts for identification of themes of discussion regarding low testosterone and testosterone replacement therapy (TRT) in order to inform how physicians may better evaluate and counsel patients.

Methods

We retrospectively extracted posts from the Reddit community r/Testosterone from December 2015 through May 2019. We applied an NLP technique called the meaning extraction method with principal component analysis (MEM/PCA) to computationally derive discussion themes. We then performed a prospective analysis of Twitter data (tweets) that contained the terms low testosterone, low T, and testosterone replacement from June through September 2019.

Results

A total of 199,335 Reddit posts and 6659 tweets were analyzed. MEM/PCA revealed dominant themes of discussion: symptoms of hypogonadism, seeing a doctor, results of laboratory tests, derogatory comments and insults, TRT medications, and cardiovascular risk. More than 25% of Reddit posts contained the term doctor, and more than 5% urologist.

Conclusions

This study represents the first NLP evaluation of the social media landscape surrounding hypogonadism and TRT. Although physicians traditionally limit their practices to within their clinic walls, the ubiquity of social media demands that physicians understand what patients discuss online. Physicians may do well to bring up online discussions during clinic consultations for low testosterone to pull back the curtain and dispel myths.
Integrating Genomics and Clinical Data for Statistical Analysis by Using GEnome MINIng (GEMINI) and Fast Healthcare Interoperability Resources (FHIR): System Design and Implementation (Preprint)
Authors: Gruendner Julian , Wolf Nicolas , Tögel Lars , Haller Florian , Prokosch Hans-Ulrich , Christoph Jan
Published: October 2020

BACKGROUND

The introduction of next-generation sequencing (NGS) into molecular cancer diagnostics has led to an increase in the data available for the identification and evaluation of driver mutations and for defining personalized cancer treatment regimens. The meaningful combination of omics data, ie, pathogenic gene variants and alterations with other patient data, to understand the full picture of malignancy has been challenging.

OBJECTIVE

This study describes the implementation of a system capable of processing, analyzing, and subsequently combining NGS data with other clinical patient data for analysis within and across institutions.

METHODS

On the basis of the already existing NGS analysis workflows for the identification of malignant gene variants at the Institute of Pathology of the University Hospital Erlangen, we defined basic requirements on an NGS processing and analysis pipeline and implemented a pipeline based on the GEMINI (GEnome MINIng) open source genetic variation database. For the purpose of validation, this pipeline was applied to data from the 1000 Genomes Project and subsequently to NGS data derived from 206 patients of a local hospital. We further integrated the pipeline into existing structures of data integration centers at the University Hospital Erlangen and combined NGS data with local nongenomic patient-derived data available in Fast Healthcare Interoperability Resources format.

RESULTS

Using data from the 1000 Genomes Project and from the patient cohort as input, the implemented system produced the same results as already established methodologies. Further, it satisfied all our identified requirements and was successfully integrated into the existing infrastructure. Finally, we showed in an exemplary analysis how the data could be quickly loaded into and analyzed in KETOS, a web-based analysis platform for statistical analysis and clinical decision support.

CONCLUSIONS

This study demonstrates that the GEMINI open source database can be augmented to create an NGS analysis pipeline. The pipeline generates high-quality results consistent with the already established workflows for gene variant annotation and pathological evaluation. We further demonstrate how NGS-derived genomic and other clinical data can be combined for further statistical analysis, thereby providing for data integration using standardized vocabularies and methods. Finally, we demonstrate the feasibility of the pipeline integration into hospital workflows by providing an exemplary integration into the data integration center infrastructure, which is currently being established across Germany.