bluuebunny/crossref_metadata_2025 huggingface dataset:
ВЗАИМОДЕЙСТВИЕ НИЗКОЧАСТОТНЫХ КОЛЕБАНИЙ В ВАРИАБЕЛЬНОСТИ РИТМА СЕРДЦА И ВАРИАБЕЛЬНОСТИ КРОВЕНАПОЛНЕНИЯ ДИСТАЛЬНОГО АРТЕРИАЛЬНОГО РУСЛА НА ФОНЕ ПРИМЕНЕНИЯ МЕТОПРОЛОЛА У ПАЦИЕНТОВ, ПЕРЕНЕСШИХ ИНФАРКТ МИОКАРДА
Authors: Kiselev A.R. , Horev V.S. , SHvarc V.A. , Karavaev A.S. , Mironov S.A. , Posnenkova O.M. , Bokeriia O.L. , Gridnev V.I.
Published: April 2020

Цель. Изучение динамики свойств двунаправленных связей между низкочастотными (НЧ) колебаниями в вариабельности ритма сердца (ВРС) и вариабельности кровенаполнения дистального артериального русла, оцениваемой по фотоплетизмограмме (ФПГ), на фоне изменения суточной дозы метопролола у больных ишемической болезнью сердца (ИБС), перенесших инфаркт миокарда (ИМ). Материал и методы. У 40 пациентов (21 мужчина и 19 женщин 637 лет), перенесших ИМ около 6 мес назад, в ходе пассивной ортостатической пробы выполняли синхронные 10-минутные записи кардиоинтервалограммы (КИГ) и ФПГ с дистальной фаланги пальца левой руки. Первую (исходную) регистрацию выполняли через 6 мес после перенесенного ИМ на фоне приема метопролола тартрата в дозе 50 мг/сут и меньше, вторую после 3 мес лечения метопрололом в максимально переносимых дозировках (100 мг/сут и больше). Результаты. Исходно не было выявлено различий между значениями задержки (в секундах) связи между НЧ-колебаний по направлению от ВРС к ФПГ и обратно. Повышение дозы метопролола способствовало снижению времени запаздывания по направлению связи от ФПГ к ВРС в вертикальном положении тела испытуемых (р0,049). Тогда как в положении лежа существенной динамики относительно исходного (до повышения дозы метопролола) уровня не выявлено. На характеристики влияния НЧ-колебаний ВРС на таковые в ФПГ изменение дозы метопролола не повлияло. Заключение. Повышение суточной дозы метопролола тартрата ассоциировалось со значимым снижением времени задержки влияния НЧ-колебаний ФПГ на ВРС только в вертикальном положении тела у пациентов, перенесших ИМ, достигая в половине случаев даже более низких значений, относительно здоровых лиц. На запаздывание обратной связи от ВРС к ФПГ повышение дозы метопролола существенно не влияло.
Optimization of a single-embryo transfer in patients with good ovarian reserve
Authors: Saraeva NV , Spiridonova NV , Tugushev MT , Shurygina OV , Sinitsyna AI , Korchagin AO
Published: April 2020

Due to refinements of assisted reproductive technology, the number of multiple pregnancies has increased substantially. Time-lapse microscopy (TLM) is a tool for selecting quality embryos for transfer. This study aimed to assess the outcomes of single-embryo transfer of autologous oocytes performed on day 5 of embryo incubation in a TLM-equipped system in patients with good ovarian reserve. The study was carried out in 208 infertile women with good ovarian reserve (over 8 oocytes retrieved). Single-embryo transfer following incubation in a TLM-equipped incubator was performed in 95 patients, who formed the main group; the control group consisted of 113 patients undergoing single-embryo transfer following a traditional culture and embryo selection procedure. We assessed the quality of transferred embryos, the rates of clinical pregnancy and pregnancy loss. Two subgroups were identified in each group of the participants: the 5SET subgroup (nonelective single-embryo transfer), which included 45 patients from the main group and 67 controls, and the 5eSET subgroup (elective single-embryo transfer), which consisted of 50 main group patients and 46 controls. The groups did not differ in terms of age, infertility factors and infertility duration. The quality of transferred embryos was excellent or good in all main group patients (100%); in the control group, the quality of transferred embryos was excellent or good in 93.8% of cases (p = 0.037). Clinical pregnancies were achieved in 64.2% of women in the main group and in 60.2% of controls (p = 0.65). Delivery rates were 54% and 51.1% in the 5eSET and 5SET subgroups of the main group, respectively (p = 0.940). For the control group, delivery rates were 54.4% and 34.3% in the 5eSET and 5SET subgroups, respectively (p = 0.052, Fisher exact test). Elective single-embryo transfer (5eSET) and the use of TLM increased the chance of pregnancy 2.17-fold (p = 0.01).
Methods for achieving energy efficiency in cloud computing
Authors: Sheikhgasanov Shamsutdin Kadievich , Kolotilov Yury Vasil'evich
Published: April 2020

The article considers the problem of cloud computing - the environment of data storage and processing that provides access to resources shared among multiple users. Cloud computing is a model for organizing remote access on request for a shared set of configurable computing resources that can be quickly allocated and freed with minimal management or interaction costs with the service provider. Using clouds significantly reduces the costs of large industrial companies and enterprises. Cloud technology helps scale your business quickly and with minimal cost, they can improve productivity together with simplifying many business processes. Cloud computing is vastly expanding opportunities, so that all large companies today are actively switching to cloud services. But this causes significant problems with energy consumption. The energy consumption by cloud computing remains a serious problem, as data processing centers grow in size. There has been proposed the approach to choosing an energy-efficient cloud architecture that aims to reduce the energy consumption of cloud applications in all deployment models, the architectures of cloud infrastructures being given. The architecture supports energy efficiency in building, deploying and operating services.
Model of security information and event management system
Authors: Kotenko Igor Vitalievich , Parashchuk Igor Borisovich
Published: April 2020

The article is focused on the development of a mathematical model of functioning the security information and event management system known as the SIEM system. This model is a formalized analytical description (in terms of a Markov chain in the form of stochastic differential equations) of the dynamics of the changing states of quality indicators characterizing the essential properties of functioning the security information and events management system in the state space. The model is a system of equations of state and observation, traditional for the Markov chain in the form of finite differences. The scientific task is to improve (modify) the algorithms for converting excitation noise used in the model. A mechanism is proposed for determining the values of the mathematical expectation increment of the simulated process, obtained on the basis of a priori data on the Markov chain, in relation to the mathematical expectation of white Gaussian noise exciting this process. Based on simple calculations the mechanism helps to decide what values can be taken by the elements of the vector of compensation additives in the equation of state of the auxiliary indicator vector of this modified model, taking into account the conversion of the excitation noise. This allows simplifying the model and reducing its computational complexity without significant losses in accuracy (adequacy). The practical application of an improved model is possible both in the framework of the research and in the systems of automated control of information security.
Práticas sustentáveis de gestão em ambiente universitário
Authors: Carvalho Renato Luiz Vieira de , Albuquerque José de Lima , Quevedo Andressa Pacífico Franco , Veloso Gelsomina Maria Bignetti , Correia Neto Jorge da Silva , Alves José Luiz
Published: April 2020

O papel do Estado traz uma expectativa de transformações, do surgimento de uma mentalidade coletiva e de uma sociedade mais consciente. A atuação do Estado na conscientização socioambiental no Brasil tem dois importantes instrumentos que são a Agenda Ambiental na Administração Pública, A3P e o Plano de Gestão e Logística Sustentável, PLS. Este estudo, aplicando uma pesquisa de natureza aplicada, de abordagem qualitativa e descritiva, analisou as práticas de responsabilidade socioambiental dos centros acadêmicos da Universidade Federal de Pernambuco, na percepção dos gestores de infraestrutura. Aplicaram-se questionários a gestores de nove centros da sede em Recife. Analisou-se cinco dimensões de práticas sustentáveis: Uso racional de energia elétrica, almoxarifados, uso racional da água, obras e reforma e descarte de resíduos. Utilizou-se uma escala Likert para mensurar as percepções dos gestores sobre práticas sustentáveis. A respeito do uso racional de energia, pode-se verificar que dentre as seis ações sustentáveis pesquisadas e referentes a este tópico, são adotadas práticas direcionadas ao uso adequado da energia elétrica. Quanto a Almoxarifados, observou-se que, dentre as cinco ações referentes a este tópico, adota-se a prática de se “aplicar uma visão de longo prazo, avaliando o ciclo de vida dos objetos a serem contratados para os serviços da infraestrutura, desde a origem até o descarte”. Quanto à gestão da água os respondentes percebem que esse tipo de ação acontece “raramente” ou “às vezes”, em suas gerências. Pode-se concluir que existem práticas sustentáveis sendo desenvolvidas, entretanto para algumas, as medidas adotadas precisam tornar-se mais efetivas.
ZIONISME DAN BERDIRINYA NEGARA ISRAEL
Authors: Sabry Muhammad Sadik
Published: April 2020

Setelah timbul pertentangan antara masyarakat Arab dan Yahudi, akhirnya lewat pertemuan tokoh-tokoh Yahudi yang dipimpin oleh Ben Gurion mendeklarasikan berdirinya negara Israel pada tanggal 14 Mei 1948. Hasil ini adalah puncak dari perjuangan mereka yang sangat panjang, melewati berbagai fase, mengkristal dalam bentuk gerakan politik Zionisme sampai akhirnya tiba pada pendirian sebuah negara Yahudi di dunia. Tetapi seiring dengan itu polemik yang berkepanjangan semakin menemukan jati dirinya sejak diproklamirkan negara tersebut dan tidak pernah tuntas diselesaikan antara Israel dan Palestina. Bahkan konflik tersebut juga meluas ke negara-negara Arab lainnya.Keywords: Zionisme, Yahudi dan Negara-negara Arab-Israel
Catatan Pembuka: Vox Populi Kembali Menyapa
Authors: Karim Syahrir
Published: April 2020

Assalamualaikum Wr. Wb.Jurnal Vox Populi merupakan jurnal berkala yang diterbitkan oleh Program Studi Ilmu Politik, Fakultas Ushuluddin, Filsafat dan Ilmu Politik, Universitas Islam Negeri Alauddin Makassar. Sejatinya jurnal ini terbit dua kali dalam setahun, yakni: Juni dan Desember. Namun karena beberapa kendala sehingga Vox Populi hanya terbit satu kali sejak 2010 dalam versi cetak, setelah itu vakum. Saat ini, Vox Populi dirasa perlu menerbitkan kembali karya-karya hasil penelitian yang khusus menerbitkan karya ilmiah mahasiswa yang dianggap penting untuk diketahui publik secara luas. Olehnya itu, dengan ucapan rasa syukur kepada Allah Swt. Vox Populi dapat kembali menyapa pembaca secara online.
Polarisasi Dukungan Politik Muslimat dan Fatayat Nahdatul Ulama Pada Pilkada Serentak Tahun 2015 di Kabupaten Luwu Utara
Authors: Zainal Ahmad Aufa , Zainal Nur Aliyah , Syam Febrianto
Published: April 2020

Studi ini mengkaji tentang polarisasi dukungan politik dan bentuk dukungan politik Muslimat dan Fatayat kepada Indah Putri Indriani-Thahar Rum  pada Pilkada Serentak 2015 di  Kabupaten Luwu Utara. Jenis penelitian yang digunakan adalah penelitian kualitatif dengan menggunakan metode deskriptif, dengan informan yang meliputi elit Muslimat dan Fatayat Luwu Utara beserta anggota yang ditentukan dengan menggunakan teknik sampling porposive.  Adapun teori yang digunakan adalah teori gender, teori partisipasi politik dan teori pilihan rasional (rational choise). Penelitian ini menunjukkan bahwa terdapat polarisasi dukungan politik yang diberikan kepada Indah Putri Indriani-Thahar Rum oleh Muslimat dan Fatayat. Secara umum dipermukaan dukungan politik yang diberikan kedua organisasi tersebut hanyalah semu sebab terdapat kepentingan politik yang berbeda antara keduanya.  Muslimat secara tegas memberikan dukungan politik sedangkan Fatayat hanya nampak dipermukaan saja sebab ada kekhawatiran yang dirasakan yakni berkaitan dengan citra dan netralitas para pengurus dan anggota dari Fatayat itu sendiri.
Peran Organisasi FKPPI Dalam Keterpilihan Adnan Purictha Yasin Limpo Pada Pilkada Serentak 2015 Di Kabupaten Gowa
Authors: Rusyd Andi Muh. Ibnu , . Ibrahim , Amsir Achmad Abdi
Published: April 2020

Penelitian ini mendiskusikan tentang peran organisasi masyarakat dalam keterpilihan Adnan Purictha Yasin Limpo pada Pilkada 2015 di Kabupaten Gowa. Adapun tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui mengapa organisasi masyarakat FKPPI memberi dukungan kepada Adnan Purictha Yasin Limpo pada Pilkada 2015 di Gowa dan strategi apa yang digunakan FKPPI untuk memenangkan Adnan Purictha Yasin Limpo. Teori yang digunakan dalam penelitian ini adalah teori organisasi, teori partisipasi dan teori strategi. Metode yang digunakan adalah penelitian deskriptif kualitatif. Kesimpulan umum dalam penelitian ini adalah bahwa dukungan suara FKPPI terhadap pasangan Adnan dalam Pilkada 2015 itu adalah keputusan bersama yang dilakukan pengurus FKPPI, dimana didasarkan pada latar belakang keluarga Adnan yang bagian dari anggota FKPPI. Di samping itu, Adnan dianggap memiliki visi misi dan program pengembangan Kabupaten Gowa yang lebih baik. Adapun strategi yang digunakan FKPPI dalam memenangkan pasangan Adnan yakni dengan melakukan sosialisasi ke berbagai masyarakat dan juga fokus pada pemilih baru, yang sebelumnya dilakukan pengenalan karakteristik daerah, kemudian memetakan wilayah.
Implementasi Media “Bosang” Untuk Mengasah Kecerdasan Logika Matematika Anak Usia Dini
Authors: Kristiana Dian
Published: April 2020

AbstrakPenelitian ini bertujuan untuk mengetahui dampak implementasi media “bosang” dalam mengasah kecerdasan logika matematika. Penelitian ini merupakan pendekatan deskriptif kualitatif. Subyek dari penelitian ini adalah siswa kelompok B BA Aisyiyah Ronowijayan Ponorogo. Untuk mendapatkan data yang valid dalam peneliti ini menggunakan teknik pengumpulan data berupa observasi langsung, wawancara, dan dokumentasi. Teknik analisis data menggunakan model Miles & Huberman dimana terdapat tiga komponen utama yang harus benar-benar dipahami yaitu reduksi data (reduction data),penyajian data (display data),dan verifikasi/kesimpulan.Hasil penelitian implementasi media bosang untuk mengasah kecerdasan logika matematika di BA Ronowijayan Ponorogo dilakukan dalam tiga pertemuan dengan menggunakan 3 macam media bosang. Pada pertemuan pertama menggunakan media bosang transportasi. Pertemuan kedua menggunakan media bosang logika dan pertemuan terakhir menggunakan media  lantai atau puzle karpet. Melalui implementasi media bosang ini, dari 15 indikator kecerdasan logika matematika yang ada sudah bisa diterapkan ada 13 indikator yaitu mengidentifikasi warna benda – benda di sekitarnya, memasangkan gambar benda dengan fungsi/kegunaannya, mengidentifikasi arah, memberi perhatian terhadap sesuatu disekitarnya, pemahaman konsep objek yang telah ditetapkan, pemahaman konsep persahabatan, menjelaskan waktu dalam rentang seminggu, merencanakan masa depan, membedakan bentuk, mengurutkan benda berdasarkan ukuran, warna, jenis permukaan dengan pola tertentu. Menghitung angka satuan, mengidentifikasi bentuk-bentuk geometri dalam satu benda serta menentukan ukuran benda yang ada disekitarnya.
Wireless Sensor Networks: Towards Resilience Against Weather-Based Disruptions
Authors: Skirelis Julius , Patlins Antons , Kunicina Nadezhda , Romanovs Andrejs , Zabasta Anatolijs
Published: April 2020

The article discusses vulnerability of wireless sensors networks to weather-based disruptions considering the opinions of different experts published in a range of scientific materials. The introduction provides a brief overview of wireless signals in real world conditions focusing on how weather affects signals (rain, fog and clouds, snow, hail, lightning, wind, bodies of water, trees and physical obstruction). Information about the effects of weather on wireless sensor networks using Free Space Optical / Radio Frequency (FSO/RF) communication is then provided. Finally, the impact of weather conditions on MANET routing protocols is considered theoretically, and experimental simulations are performed by comparing the sustainability of different protocols to different weather conditions. After analysis of experiment results, ideas on how to decrease vulnerability of wireless networks to weather-based disruptions are discussed.
Free and Open Source Software Codes for Antenna Design: Preliminary Numerical Experiments
Authors: Fedeli Alessandro , Montecucco Claudio , Gragnani Gian Luigi
Published: April 2020

In both industrial and scientific frameworks, free and open source software codes create novel and interesting opportunities in computational electromagnetics. One of the possible applications, which usually requires a large set of numerical tests, is related to antenna design. Despite the well-known advantages offered by open source software, there are several critical points that restrict its practical application. First, the knowledge of the open source programs is often limited. Second, by using open source packages it is sometimes not easy to obtain results with a high level of confidence, and to integrate open source modules in the production workflow. In the paper, a discussion about open source programs for antenna design is carried out. Furthermore, some preliminary numerical tests are presented and discussed, also in comparison with those obtained by means of commercial software. Results are related to the simulation of various typologies of antennas in order to assess the capabilities of open source software in different configurations. The presented comparisons show that, despite the abovementioned limitations, the examined open source packages have similar performance with respect to their commercial counterparts.
Real-Time Monitoring & Adaptive Protection of Power Transformer to Enhance Smart Grid Reliability
Authors: Raichura Maulik , Chothani N. G. , Patel Dharmesh
Published: April 2020

Power transformer is one of the most important pieces of equipment in the grid to reliably and efficiently transmit power to the consumers. Asset management and protection are the best concepts for prolongation of transformer lifespan as well as for the increase of grid reliability. This article presents electrical and non-electrical parameter-based power transformer monitoring and protection. Various data such as core flux, age of asset, heat generation, current harmonics and temperature are monitored in real time and processed accordingly to enhance the working capability of the transformer. The proposed scheme is successfully tested on 15 kVA laboratory transformer using Arm CORTEX-M4 processor. A Fitness Function (Ff) is estimated from the collected data to examine the working condition of the transformer. Moreover, voltage, current and power-based inrush detection as well as Adaptive Power Differential Protection (APDP) are applied to protect the transformer against fault. The hardware implementation and result validation prove the effectiveness of the proposed scheme in enhancing reliability of the distribution grid.
New host and locality record of Parapharyngodon japonicus (Nematoda: Oxyuroidea) from the Egyptian changeable lizard Agama mutabilis (Agamidae): A light and scanning electron microscopy
Authors: Morsy K. , Al-Kahtani M. , Shati A. , El-Kott A. , Abdel-Gaber R. , Fol M.
Published: April 2020

Parapharyngodon (Oxyurida) is a lizard gastrointestinal nematode parasite with a life cycle including lizards as main hosts. However, some species are known to parasitize anurans. In the present study, P. japonicus isolated from the large intestine of the Egyptian changeable lizard, Agama mutabilis was described and illustrated. Forty five specimens of these animals were collected from south Sinai desert, Egypt during the period from May to September 2017. After necropsy, the body was opened by a longitudinal incision from vent to throat, and the gastrointestinal tract was removed. The esophagus, stomach, small and large intestines were examined separately for helminthes. The recovered nematodes were examined by light and scanning electron microscopy. Thirty six specimens (80.0 %) were found to be naturally infected. The parasite was robust with prominent cuticular transverse annulations. Mouth surrounded by three bilobed lips, each with tiny labial papillae. Three pairs of caudal papillae were observed in male worms; 1 pair precloacal, 1 pair sublateral in cloacal opening line, 1 pair in proximal region of caudal appendage on its narrowed point. The posterior extremity beard dorsally directed caudal appendages. Females were with a conical posterior end terminated at a terminal spike. Ovaries reached esophageal isthmus but not wrapped around corpus. The parasite recorded was compared morphologically and morphometrically with the most similar species, it was found that it was most similar to P. japonicus with new host and locality records.
How do Amateur Endurance Runners Alter Spatiotemporal Parameters and Step Variability as Running Velocity Increases? A Sex Comparison
Authors: García-Pinillos Felipe , Jerez-Mayorga Daniel , Latorre-Román Pedro Á. , Ramirez-Campillo Rodrigo , Sanz-López Fernando , Roche-Seruendo Luis E.
Published: April 2020

This study aimed to analyse the effects of running velocity on spatiotemporal parameters and step variability in amateur endurance runners, according to sex. A group of 51 males and 46 females performed an incremental running test on a treadmill (10-16 km/h). Spatiotemporal parameters (contact and flight time, step length, step frequency and step angle [CT, FT, SL, SF, SA]) and step variability, in terms of within-participant standard deviation (SD), were recorded through the OptoGait System. The ANOVA showed significant differences in the magnitude of the spatiotemporal parameters as running velocity increased (p < 0.001). It also revealed significant differences in step variability (p < 0.005) over the entire running protocol. Between-sex differences in CT, SL, SL-normalized and SF (p < 0.05, ES = 0.4-0.8) were found. Differences were also found in step variability at high velocities (15-16 km/h), with males showing a greater SD than females. In conclusion, increasing running velocity makes CT shorter, FT and SL longer, and SF and SA greater in amateur endurance runners, changing step variability, regardless of sex. Additionally, some between-sex differences were found in spatiotemporal parameters and step variability.
Quantification of Movement Characteristics in Women’s English Premier Elite Domestic Rugby Union
Authors: Bradley Edward J , Board Lisa , Hogg Bob , Archer David T
Published: April 2020

This study aims were to determine the positional physical requirements of English domestic women’s rugby union match-play. Global positioning system data (Catapult Minimax S4) were collected at 10 Hz of 129 competitive player games from the Tyrrells Premier15 league. Players were classified according to broad (Forwards, Backs) and specific positions (front-, second-, back-row, scrum-half, inside-, and outside-backs). Total distances, maximum speed, and player loads were calculated. Mean total distance was 4982 m and was similar between the Forwards and Backs, with second-row players covering the most (5297 m) and outside-backs the least (4701 m). Inside- and outside-backs covered a significantly greater distance at high speed running (134 m; 178 m) and sprinting (74 m; 92 m) speeds, respectively, whereas the second- and back-row covered greater distances jogging (1966 m; 1976 m) and the front-row spent the greatest overall distance walking (2613 m). Outside-backs reached greater maximum speed than all other positions (24.9 km.h-1). The mean player load was highest in the back-row (562 AU) and second-row (555 AU) and these were higher than the outside-backs (476 AU). These findings indicate that the demands placed on female rugby players are position specific and differ from male players. Additionally, the data are the first obtained from the 10 Hz GPS and from within English domestic women’s rugby, thus adding to the overall limited data available on women’s rugby union.
Muscle Recruitment Pattern of The Hamstring Muscles in Hip Extension and Knee Flexion Exercises
Authors: Yanagisawa Osamu , Fukutani Atsuki
Published: April 2020

We aimed to compare dynamic exercise performance between hip extension exercises with different knee angles and between knee flexion exercises with different hip angles, and to investigate the recruitment pattern of the hamstrings in each exercise. Seven men performed 4 isokinetic exercises (3 maximal concentric contractions at 30°/s (peak torque) and 30 maximal concentric contractions at 180°/s (total work)): hip extension with the knee fully extended (HEke) and with the knee flexed at 90° (HEkf) and knee flexion with the hip fully extended (KFhe) and with the hip flexed at 90° (KFhf). The recruitment pattern of the hamstrings was evaluated in each exercise using magnetic resonance imaging (T2 calculation). The HEke condition showed significantly greater peak torque than the HEkf condition (p < 0.05). The KFhf condition had significantly greater peak torque and total work values than the KFhe condition (p < 0.05). Although the biceps femoris long head, semitendinosus, and semimembranosus had significantly increased post-exercise T2 values in the HEke (p < 0.05), KFhe, and KFhf conditions (p < 0.01), the T2 increase values were significantly greater under the KFhf than the HEke condition (p < 0.05). The semitendinosus showed a significantly greater T2 increase value than other muscles under both KFhe and KFhf conditions (p < 0.05). Performance of hip extension and knee flexion exercises increases when the hamstring muscles are in a lengthened condition. The hamstring muscles (particularly the semitendinosus) are more involved in knee flexion than in hip extension.
Activity of Trunk and Lower Extremity Musculature: Comparison Between Parallel Back Squats and Belt Squats
Authors: Joseph Lori , Reilly Josh , Sweezey Kristine , Waugh Robyn , Carlson Lara A. , Lawrence Michael A.
Published: April 2020

The back squat is widely used in strength training programs. Alternatively, the belt squat has been gaining popularity since it loads the weight on the hips, as opposed to the shoulders and spine. The purpose of this study was to determine whether using a belt squat would result in less lumbar extensor activation while providing similar excitation of other prime mover and stabilizer musculature. Ten participants (9 males, 1 female; age 29.3 ± 4.9 years; body mass 96.2 ± 17.8 kg) who regularly trained both belt squats and back squats performed three sets of 5 repetitions with 100% bodyweight for each exercise. Peak and integrated muscle activity was calculated and normalized to a maximum voluntary isometric contraction. A one-way ANOVA (p < 0.05) was used to compare conditions. Belt squatting decreased lumbar erector impulse (45.4%) and peak (52.0%) activation as compared to the back squat. Belt squatting did not alter activation of the lower extremities except for a decrease in the gluteus maximus (35.2% impulse and 32.1% peak), gluteus medius (54.1% impulse and 55.2% peak). Furthermore, belt squatting reduced activation of the rectus abdominus (44.3% impulse; 31.1% peak), and external obliques (45.8% impulse; 53.7% peak) as compared to back squatting. Our results suggest belt squatting provides similar muscular demands for the quadriceps, hamstrings, and plantar flexors, but is less demanding of trunk stabilizers, and gluteual muscles. Belt squats may be a suitable alternative to back squats in order to avoid stressing low back or trunk musculature.
Conceptual and Rating Model of the V-SMARTH Smart University
Authors: Duc Nguyen Huu , Thuy Ha Quang , Son Pham Bao , Hieu Tran Trong , Cuong Ton Quang
Published: April 2020

The conceptual model of smart university has been generalized as a digital transformation-oriented higher educational institution using digital infrastructure (digital legal, digital human resources, digital data, digital technologies and digital applications) to provide personalized learning services to learners of all generations in the country and around the world, meeting the lifelong learning requirements and sustainable development of individuals as well as nations. It is described through the V-SMARTH model, including 6 basic components of digital resources, open access learning materials, virtual learning environment, individualized education, interactive learning and digital platform. These elements come together in three pillars of digitization, digital learning model innovation and comprehensive digital transformation process. The study also approached the notion of the smartness and the readiness level of the smart university. In particular, the issue of performance metrics of smart universities has been developed and implemented with the UPM rating for the VNU University of Engineering and Technology.
Antibacterial Potency of Fresh Extract Leaves of Jamaican Cherry (Muntingia calabura L.) in Inhibiting the Growth of Shigella dysenteriae
Authors: Yanis Ikel Fitri , Alamsjah Feskaharny , Agustien Anthoni , Maideliza Tesri
Published: April 2020

Research on the antibacterial potency of fresh extract from leaves of Jamaican cherry (Muntingia calabura L.) in inhibiting the growth of Shigella dysenteriae had been conducted in the Microbiology Laboratory, Department of Biology, Faculty of Mathematics and Natural Sciences, Andalas University. The study aimed to determine the potential of fresh extract from  Jamaican cherry leaves in inhibiting the growth of S. dysenteriae and to determine its Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) against S. dysenteriae. The results showed that the fresh extract of Jamaican cherry leaves was potent as an antimicrobial agent against pathogenic bacteria S. dysenteriae. It was shown through 12 - 14 mm diameter of inhibition zone which was classified as strong inhibition. The MIC was measured at 3.125% while MBC was undetermined. According to these findings, it can be concluded that the fresh extract from Jamaican cherry leaves was potent to inhibit the growth of S.dysentriae at 3.125% concentration, yet unable to kill it.
EKSEKUSI JAMINAN HAK TANGGUNGAN SECARA DI BAWAH TANGAN
Authors: RAHMAWATI AYU CITRANING
Published: April 2020

Not all creditors can return credit as promised in the contract. In an effort to guarantee the creditor's trust in paying off credit by the debtor, a collateral object is needed. In respect of collateral objects, immovable property is bound with Mortgage Guarantee institutions. But there are often problems in executing collateral objects. Normative legal research that discusses doctrinal law, uses the statutory approach and the concept approach. The purpose of this study is to find the most effective way to carry out executions that benefit both parties. Execution of collateral can be done through public auctions or underhanded execution. Execution of Credit Collateral which is burdened with Under Right Handling Rights is one of the alternatives that is considered easier and must take precedence.Keywords: Execution, Collateral, Mortgage Rights, Under the Hand
CITRA UBUD BALI BERDASARKAN PETA KOGNISI MASYARAKAT
Authors: Anggi Mutiara , Pramitasari Diananta , Marcillia Syam Rachma
Published: April 2020

Berbagai kota maupun wilayah di Indonesia banyak memiliki potensi pariwisata yang menarik sehingga dikunjungi oleh turis dari berbagai macam negara. Salah satunya adalah area Ubud Bali yang memiliki banyak destinasi wisata dan terus berkembang untuk memenuhi kebutuhan pariwisatanya. Perkembangan yang pesat tersebut dikhawatirkan akan menyebabkan kepadatan lingkungan yang tidak terkendali dan berubahnya citra Ubud sebagai kawasan alam dan pedesaan yang tenang. Oleh karena itu, penelitian ini dilakukan untuk mengetahui citra Ubud berdasarkan kognisi spasial yang tergambar melalui peta kognisi (cognitive map) masyarakatnya. Citra Ubud tersebut diharapkan dapat digunakan sebagai pertimbangan untuk perkembangan area Ubud nantinya. Penelitian yang dilakukan di area Ubud, Kabupaten Gianyar, Bali ini menggunakan metode penelitian pemetaan kognisi (cognitive mapping). Melalui metode ini sebelas responden diminta untuk menggambarkan sketsa peta area Ubud dengan menunjukkan lima elemen kota menurut Kevin Lynch, yaitu landmark, node, path, district, dan edge. Dari sebelas cognitive map yang tergambar, didapatkan hasil bahwa Ubud memiliki citra kawasan sebagai kawasan wisata yang masih memegang kuat budayanya. Hal ini ditunjukkan melalui perempatan Ubud dan Monkey Forest sebagai elemen spasial yang tertanam kuat dalam kognisi responden.IMAGE OF UBUD BALI BASED ON COGNITIVE MAP OF THE DWELLERS Various regions in Indonesia have many attractive tourism potentials and are visited by tourists from various countries. One of them is the area of Ubud, Bali, which has many tourist destinations and continues to grow to meet the needs of tourism. This rapidly growing tourism will raise some concerns about uncontrolled urban density and the alteration of Ubud’s image as a peaceful and natural rural area. Therefore, this research was conducted to find out the image of Ubud based on the dwellers’ spatial cognition, which is drawn through their cognitive maps. This image of Ubud is expected to be used as a consideration for the development of the Ubud area. The research was conducted in the area of Ubud, Gianyar, Bali, and used cognitive mapping as the research method. Through this method, eleven respondents were asked to sketch the maps of Ubud area by showing five city’s elements, according to Kevin Lynch. Those elements are landmark, node, path, district, and edge. From eleven cognitive maps drawn, the obtained result is that Ubud has the image of a tourist area that still holds a strong culture. This is shown through the intersection of Ubud and Monkey Forest as spatial elements that are firmly embedded in the respondents’ spatial cognition.
TIPOLOGI BANGUNAN DI PERMUKIMAN BANTARAN SUNGAI BERDASARKAN LOKASI DAN JENIS KONSTRUKSI (STUDI KASUS: PERMUKIMAN BANTARAN SUNGAI KAHAYAN, PALANGKARAYA)
Authors: Murti Nindita Kresna , Suprapti Atiek , Sardjono Agung Budi
Published: April 2020

Rumah yang berada di permukiman bantaran Sungai memiliki keunikan dan karakter tersendiri, hal ini dikarenakan fisik bangunan rumah menyesuaikan dengan kondisi dan lingkungan di daerah bantaran sungai. Pulau Kalimantan dibelah oleh sungai – sungai besar yang memiliki keunikan dan kondisi lingkungan yang berbeda satu dan yang lain, misalnya Sungai Kahayan yang membelah kota Palangkaraya memiliki kondisi dimana ketinggian pasang surut air sungai yang sangat tinggi dan terdapat permukiman awal terbentuknya Kota Palangkaraya. Bangunan rumah di permukiman yang berada di bantara Sungai Kahayan memiliki 3 segmen, yaitu 1) bangunan rumah yang bearda di atas air (apung/lanting), 2) bangunan rumah yang berada di bantaran/transisi antara air dan daratan (panggung), 3) bangunan rumah yang berada di darat. Metode yang di gunakan adalah metode kualitatif deskriptif, metode ini bertujuan untuk mengambarkan dan mendeskripsikan tipologi berdasarkan jenis struktur dan ruang pada bangunan di permukiman ini. Tujuan Penulisan artikel ini untuk mengetahui tipologi  bangunan rumah  di bantaran Sungai Kahayan yang terdiri dari segmen bangunan di atas air, panggung, dan bangunan yang di darat, berdasarkan konfigurasi bentuk dan ruang (spatial structure). Hasil dari penulisan paper ini adalah lokasi rumah dan perkembangan permukiman ini mempengaruhi tipologi yang terbentuk.BUILDINGS TYPOLOGY IN RIVERFRONT SETTLEMENTS BASED ON LOCATION AND TYPE OF CONSTRUCTION (CASE STUDY: KAHAYAN RIVER SIDE SETTLEMENTS, PALANGKARAYA)Houses in riverbank settlements have their uniqueness and character, and this is because the physical building of the house adapts to the conditions and environment in the riverbanks. Borneo is divided by large rivers that have unique and different environmental conditions; for example, the Kahayan River, which divides the city of Palangkaraya has a condition where the tidal height of the river is very high, and early settlements forming the City of Palangkaraya. Houses in settlements located on the riverbanks of the Kahayan have 3 segments, 1) Houses that are built on water (floating/lanting), 2) Houses that are located on the banks/transitions between water and land (stage), 3) house building in the land. The method used is a descriptive qualitative method; this method aims to describe and describe typologies based on the type of structure and space in buildings in this settlement. Purpose The writing of this paper seeks to find out the typology of house buildings on the banks of the Kahayan river, which consists of building segments on water, stage buildings, and buildings on the land, based on their spatial structure configurations. The results of this paper are the location of the house and the development of this settlement affect the typology that is formed.
In Silico Identification of Widely Used and Well Tolerated Drugs That May Inhibit SARSCov- 2 3C-like Protease and Viral RNA-Dependent RNA Polymerase Activities, and May Have Potential to Be Directly Used in Clinical Trials
Authors: Gul Seref , Ozcan Onur , asar sinan , Okyar Alper , Barıs Ibrahim , Kavakli Ibrahim Halil
Published: April 2020

Despite drastic strict measures, the spread of the SARS-CoV-2 is ongoing all around the world. There is no vaccine developed against this virus and no approved medication to be used for the treatment of COVID-2019. In this study, we performed in silico screening against two critical enzymes (3C-like protease (3CLpro) and viral RNA-dependent RNA polymerase (RdRp)), which play important roles in the SARS-CoV-2 life cycle, by using the U.S. Food and Drug Administration (FDA) approved drugs. Our docking simulations enable us to identify several hundred drugs that have high binding affinity for each target. To evaluate persistence of the drugs’ binding to each target near to physiological conditions we selected well tolerated and widely used ones for the molecular dynamics simulations. Simulations results revealed that following drugs were stably interacting with SARS-Cov-2 3CLpro: tetracycline and its derivatives, dihydroergotamine, ergotamine, dutasteride, nelfinavir, and paliperidone. A similar analysis with RdRp showed that eltrombopag, tipranavir, ergotamine, and conivaptan were bound with the enzyme during the simulation with high binding energy. Detailed analysis of docking results suggested that ergotamine, dihydroergotamine, bromocriptine, dutasteride, conivaptan, paliperidone, and tipranavir can bind to both enzymes with high affinity. Since these drugs are well tolerated, cost effective and widely used, our study suggested that they have potential to be used in clinical trial for the treatment of SARS-CoV-2 infected patients.
Structure–activity Relationships of Glutathione Peroxidase 4 Inhibitor Warheads
Authors: Eaton John , Furst Laura , Cai Luke , Viswanathan Vasanthi S. , Schreiber Stuart L.
Published: April 2020

Direct inhibition of GPX4 requires covalent modification of the active-site selenocysteine. While phenotypic screening has revealed that activated alkyl chlorides and masked nitrile-oxides can inhibit GPX4 covalently, a systematic assessment of potential electrophilic warheads with the capacity to inhibit cellular GPX4 has been lacking. Here we survey more than 25 electrophilic warheads across several distinct GPX4-targeting scaffolds. Surprisingly, we find that electrophiles with attenuated reactivity compared to chloroacetamides are unable to target GPX4. The highly reactive propiolamide warheads we uncover in this study highlight the potential need for masking strategies similar to those we have described for nitrile-oxide-based GPX4 inhibitors. Finally, our observations that there are spatial requirements between warhead and scaffold for achieving optimal GPX4 targeting and that certain low-molecular-weight analogs inhibit GPX4 with selectivity suggest that rational design of GPX4 inhibitors may be a productive approach. The generation of ligand-bound crystal structures to facilitate such studies should therefore be prioritized by the field.
Smart Chemiluminescence Probes and Dual-Amplification of Signal for Detection of Amyloid Beta Species in Alzheimer’s Disease Model
Authors: Yang Jing , Yin Wei , Van Richard , Yin Keyi , Wang Peng , Zheng Chao , Zhu Biyue , Ran Kathleen , Zhang Can , Shao Yihan , Ran Chongzhao
Published: April 2020

Fluorescence and chemiluminescence imaging are the most widely applied optical emissive imagingmethods in biomedical research. “Smart” (turn-on) fluorescence imaging has been routinely used for invitro, cellular, and in vivo imaging; however, smart chemiluminescence imaging has been rarely explored.In this report, we designed chemiluminescence probe ADLumin-1 and validated that ADLumin-1 was asmart chemiluminescence probe for amyloid beta (Ab) species, evidenced by a 216-fold amplification ofchemiluminescence intensity upon mixing with Abs in vitro. In vivo two photon imaging indicated thatADLumin-1 could efficiently cross blood-brain- barrier (BBB) and provided excellent contrast both for Abplaques and cerebral amyloid angiopathy (CAA). In vivo whole brain imaging showed that thechemiluminescence signal of ADLumin-1 from 5-month-old transgenic AD (5xFAD) mice was 1.80-foldhigher than that from the age-matched wild-type mice. Moreover, we demonstrated that it was feasible tofurther dually-amplify signal via chemiluminescence resonance energy transfer (DAS-CRET) using twonon-conjugated smart probes (ADLumin-1 and CRANAD-3) in solutions, brain homogenates, and in vivowhole brain imaging. Our results showed that DAS-CRET could provide a 2.25-fold margin between 5-month-old 5xFAD mice and wild type mice. To our knowledge, this is the first report that achemiluminescence probe could be used for detecting Ab species both in vitro and in vivo. AlthoughADLumin-1 was designed for Abs, we believe that our strategy could be potentially extended to a widerange of targets, including other aggregating-prone proteins. Notably, our results suggested that thestrategies for turning-on fluorescence could be used for amplifying chemiluminescence, and we believe thatour studies could inspire considerably more research on chemiluminescence imaging
Structure-Based Virtual Screening of a Natural Product Database to Identify Several Possible SARS-CoV-2 Main Protease Inhibitors
Authors: Ettayapuram Ramaprasad Azhagiya Singam , La merrill Michele , Durkin Kathleen A. , Smith Martyn T.
Published: April 2020

A novel coronavirus (SARS-CoV-2) has been the cause of a recent pandemic of respiratory illness known as COVID-19. The lack of anti-viral drugs or vaccines to control the infection has resulted in an enormous number of seriously ill patients requiring hospitalization. In the absence of an effective vaccine, there is an urgent need for therapies which can fight COVID-19 infection. Readily available compounds in foods and plants may be one source of anti-viral compounds. Here, natural product chemicals from the Nuclei of Bioassays, Ecophysiology and Biosynthesis of Natural Products Database (NuBBEDB) were screened against the main protease (Mpro) of SARS-CoV-2. This protease was chosen as a target due to its importance in the replication of SARS-CoV-2. Molecular docking was used to screen the natural products against Mpro to identify potential candidates. The identified candidates were further filtered using molecular dynamics simulation investigation. Nine natural compounds were identified for experimental validation, with carlinoside and quercetin 3-o-sophoroside being the top candidates.
Surface and Catalyst Driven Singlet Oxygen Formation in Li-O2 Cells
Authors: Samojlov Aleksej , Schuster David , Kahr Jürgen , Freunberger Stefan
Published: April 2020

Large overpotentials upon discharge and charge of Li-O2 cells have motivated extensive research into heterogeneous solid electrocatalysts or non-carbon electrodes with the aim to improve rate capability, round-trip efficiency and cycle life. These features are equally governed by parasitic reactions, which are now recognized to be caused by the highly reactive singlet oxygen (1O2). However, the link between the presence of electrocatalysts and 1O2 formation in metal-O2 cells is unknown. Here, we show that, compared to pristine carbon black electrodes, a representative selection of electrocatalysts or non-carbon electrodes (noble metal, transition metal compounds) may both slightly reduce or severely increase the 1O2 formation. The individual reaction steps, where the surfaces impact the 1O2 yield are deciphered, showing that 1O2 yield from superoxide disproportionation as well as the decomposition of trace H2O2 are sensitive to catalysts. Transition metal compounds in general are prone to increase 1O2.
Kinetic Control over Droplet Ripening in Fuel-Driven Active Emulsions
Authors: Tena-Solsona Marta , Janssen Jacqueline , Wanzke Caren , Schnitter Fabian , Park Hansol , Rieß Benedikt , Gibbs Julianne M. , Weber Christoph A. , Boekhoven Job
Published: April 2020

Active droplets are made of phase-separated molecules that are activated and deactivated by a metabolic reaction cycle. Such droplets play a crucial role in biology as a class of membrane-less organelles. Moreover, theoretical studies show that active droplets can evolve to the same size or spontaneously self-divide when energy is abundant. All of these exciting properties, i.e., emergence, decay, collective behavior, and self-division, are pivotal to the functioning of life. However, these theoretical predictions lack experimental systems to test them quantitively. Here, we describe the synthesis of synthetic active droplets driven by a metabolic chemical cycle and we find a surprising new behavior, i.e., the dynamics of droplet-growth is regulated by the kinetics of the fuel-driven reaction cycle. Consequently, these droplets ripen orders of magnitude faster compared to Ostwald ripening. Combining experiments and theory, we elucidate the underlying mechanism, which could help better understand how cells regulate the growth of membrane-less organelles.
Implementation of Discovery Learning to Improve Scientific and Cognitive Attitude of Students
Authors: Syarif Erman , Syamsunardi Syamsunardi , Saputro Alief
Published: April 2020

This study aims to determine the implementation of discovery learning in improving scientific and cognitive attitudes of students. This type of research is a classroom action research conducted in class X Is7. Each cycle consists of four stages, namely planning, implementing, observing, and reflecting. The instruments in this study were observation sheets, scientific attitude questionnaires and cognitive tests. The results showed: 1) the scientific attitude of the first cycle students showed an average value of 3.9 in either category. Cycle II scientific attitudes of students showed an average value of 4.4 in either category. 2) the average cognitive value in the first cycle with a value of 70.18 in the sufficient category and an increase in the second cycle with a value of 89.23 in the very high category. This improvement illustrates that students have an effort in mastering subject matter. Discovery learning has a positive impact in improving students 'scientific and cognitive attitudes which are marked by an increase in students' learning completeness in each cycle.