bluuebunny/crossref_metadata_2025 huggingface dataset:
CRISPR-edited CAR-T cells: Using CRISPR-Cas9 to Improve CAR-T Therapy
Authors: Ajavavarakula Tatchapon
Published: October 2022

One of the cornerstones of cancer immunotherapy, chimeric antigen receptor T cell (CAR-T) immunotherapy is a treatment comprising of T cells transfected with artificial receptors that target a specific tumor antigen, potentiating tumor destruction. Despite the effectiveness of this technique in treating hematopoietic malignancies, efficacy against other cancers leaves much to be desired. CAR-T therapy's anti-tumor effectiveness, safety, and accessibility are hampered by issues such T cell exhaustion, toxicity, and ineffective production techniques. With the advent of CRISPR-Cas9 technology, allowing ease of genome editing, it is now possible to address these challenges. By introducing a double-strand break at a particular genomic location, this gene editing technology can be utilized to target inhibitors of T lymphocyte function, directed to specific loci to produce a less toxic product, and engineer allogeneic CAR-T cells. However, CRISPR-Cas9 confers its own limitations, including off-target editing. This review introduces the applications of CRISPR technology to CAR-T therapy and evaluates how the technology can optimize the effectiveness, safety, and product availability of this cancer immunotherapy. This paper also addresses some of the potential drawbacks of CRISPR-edited CAR-T cells.
New Targets of CAR-T Therapy for B-cell lymphoma
Authors: Shi Lanya
Published: October 2022

B-cell lymphoma is a kind of hematologic malignancy with high morbidity and mortality, which is usually treated by chemoimmunotherapy followed by an autologous transplant. But the traditional therapy usually leads to relapse and refractory. Now FDA has approved four CAR-T cell products that all target CD19 to give relapsed or refractory patients another chance to control cancer. These achievements may thank the CD19, but the CD19 also leads to some problems including the off-tumor effect and antigen escape that result in off-tumor effects and relapses. These problems prevent CAR-T therapy from being widely used in treating B-cell lymphoma. To solve these problems, new targets should be discovered. Scientists have already done a lot of exploration in this area. To give the scientists some directions, this paper will briefly introduce the two problems, the characteristics that are required for the ideal targets, and some ideal future targets which are understudy now.
Analysis of the causes associated with depression
Authors: Wu Wenzheng , Shan Pufan , Meng Chengzhen , Yu Xinxin , Mou Yunying , Wang Shihao
Published: October 2022

Depression is a common and complex depressive disorder that is characterised by significant and persistent depression, usually with a prolonged onset (longer than two weeks) and a tendency for recurrent episodes. In today's rapidly developing society, the incidence of depression continues to rise, making research and treatment of depression even more urgent. This paper therefore analyses and summarises the causes of depression based on existing clinical trials and research in three areas: 5-hydroxytryptamine, viral factors and parasitic factors.
Exploring the process of deep integration of medical testing and clinical care
Authors: Song Minghui , Shan Pufan , Meng Chengzhen , Yu Xinxin , Mou Yunying , Song Minghui
Published: October 2022

With the rapid development of science and technology and medical technology, the development of medical testing technology is on the fast track and is becoming increasingly integrated into clinical care. This phenomenon has revolutionized the medical profession, but at the same time, the pitfalls This paper examines the process of integrating medical testing and clinical care in depth, discusses the current state of This paper examines the process of integrating medical testing and clinical care in depth, discusses the current state of integration and makes recommendations accordingly.
Molecular mechanism study of cancer treatment based on network pharmacology of lily
Authors: Wang Shihao , Shen Jinqiu , Zhang Boyang , Tian Jiao , Zhao Wei , Wu Wenzheng
Published: October 2022

OBJECTIVE: To make predictions related to the treatment of cancer by lily. METHODS: A systematic study of the constituents, targets and pathways of lily and cancer treatment was conducted using network pharmacology and molecular docking methods. The active ingredients of lily were screened and selected for investigation using TCMSP, Uniprot and PubChem databases, and the "ingredient-target-pathway" correlation axis was established. PubChem was used to collect the compounds in lily, and the active ingredients and targets with OB≥30% and DL≥0.18 in lily were obtained using the TCMSP Chinese medicine database. The active ingredients that met the criteria were also screened, and the binding patterns of the core targets and active ingredients were verified using molecular docking techniques before the active ingredients in lily were genetically aligned using Uniprot, and the corresponding genes were collated. The genes of different cancers were collated using CTD. Cytoscape 3.9.0 was used to create a map of the active ingredients and their corresponding targets. Finally, the results obtained were used to make predictions related to the treatment of cancer in lily. Results: The herb-compound-target network was obtained through screening. After cross-matching the active targets of the chemical components in lily with various cancers, 42 intersecting targets were obtained. Conclusion: The rank values (degree) of the intersecting targets were analysed and six targets with a degree greater than 5 were found to be PTGS2 (12), MMP1 (10), PPARG (8), HSP90AA1 (8), TP53 (8) and ESR2 (6); the diseases that were closely linked to the targets were Cancer, unspecific (The findings of this paper may provide a reference for the development of relevant targeted drugs and targeted therapeutic approaches in the future.
Preface: 4th International Conference on Computer Engineering, Information Science and Internet Technology (CII 2022)
Authors: Symons Lawrence , Yu Rongfa
Published: October 2022

The organizing Committee of CII 2022 warmly welcomes you to join the 4th International Conference on Computer Engineering, Information Science and Internet Technology (CII 2022), which was held on September 24-25, 2022 in Sanya City, China.

On the move towards the 21st century, Computer Engineering, Information Science and Internet Technology are the important tools to solve the global problems, e.g. the energy and environmental problems, as well as to foster the prosperities for a better life. They are created from the simple ideas that make the difference, the ideas that connect the dots of different fields of knowledge.

Thus, the objective of this conference is to gather engineers, scientists and innovators to share their new findings and ideas in different fields of knowledge. This is to share their experiences in specific domains as well as across the fields with the aim at provoking emerging innovative ideas and further collaborations.

Hopefully, all participants and other interested readers benefit scientifically from the proceedings and also find it stimulating in the process.

With our warmest regards,

Lawrence Symons, Rongfa Yu

Conference Organizing Chair
An automatic reconstruction method of fibula for mandibular defect
Authors: Huang Ruiming , Hu Junlei , Liu Jiannan
Published: October 2022

Purpose: For patients who need to reconstruct the mandible with the fibula, this article gives an automated design scheme to save the doctor's time. Methods: First, perform the initial registration by analyzing the characteristic points of the fibula and jaw defect, cut the fibula and move it to the approximate location. Then optimize and adjust, and finally give a plan. Results The average operating time is about 10s for each reconstruction planning. Six surgeons at different levels were invited to rate the output of our method and manual operations by expert and novice, the evaluation of our method is even higher than that of the experts. Conclusions: The proposed method can automatically accomplish the task. At the same time, it is self-defining, allowing doctors to select the required feature points based on their own experience. This design has application value in the design of surgical plan.
Application of Blockchain and Distributed Storage Technology
Authors: Liu Zhiying
Published: October 2022

With the rapid development of Internet technology, enterprise-level storage and cloud storage have become the standard tools for enterprises to meet their computing and storage needs. Due to the defects of traditional decentralized data storage system, blockchain and distributed storage technology has been widely applied to the modern enterprises. Blockchain storage refers to a decentralized storage system built with blockchain incentives, which is an effective combination of blockchain and storage system. There are many achievements and various breakthroughs in this field and both theoretical and applied research have developed rapidly. This paper discussed the research progress on blockchain and distributed storage technology. In addition, the advantages of blockchain storage technology were also discussed. Blockchain storage can effectively avoid the negative impact of a single point of failure. It can improve availability by distributing the load to nodes around the world. Last but not least, the applications for blockchain and distributed storage technology such as data storage, money transfers, and financial exchanges were discussed. The current knowledge, and perspectives of blockchain and distributed storage technology in modern enterprises could provide a good reference for the future research.
The Application of Machine Vision in Intelligent Manufacturing
Authors: Wang Cheng
Published: October 2022

Machine vision technology has a rapid development rate in recent year especially in intelligent manufacturing. The field of intelligent manufacturing will undergo a revolution. Machine vision technology is currently developing and becoming more sophisticated. The related hardware and software items are continuously improved. They increasingly became significant in the industrial production process. Machine vision can replace some human labor in intelligent manufacturing, which effectively increases production efficiency and product quality. As a result, it might help businesses achieve full production automation, quality control standardization, automation, and automation. This paper discussed the key technologies of machine vision technology used in intelligent manufacturing industry, as well as the application of machine vision in intelligent manufacturing. The Key technologies of machine vision include image acquisition, image segmentation, and image recognition. The current application of machine vision in intelligent mainly include manufacturing dimensional measurement, part inspection, and object localization.
The Development of Telecom Equipment
Authors: Li Hongyang
Published: October 2022

The telecom equipment industry is one of the most competitive industries globally. It is characterized by a few big corporations that dominate the industry. The industry is also among the industries that have been leveraging Data Analytics, especially Big Data Analytics. One of the big players in this industry is Huawei. Huawei is a Chinese multinational company that is involved in the sale of production and sale of telecommunication equipment, smart devices, and various consumer electronics. This shows how Huawei applies Data Analytics to manage its human resource, accounting, and finance, product design and development, supply chain and logistics, sales and marketing, and support services. The report also makes predictions of what the future of Analytics will look like for this industry. It is predicted that data volume for companies will continue to grow, creating space issues. It is also projected that the use of machine learning will accelerate, and advanced analytics applications will be needed.
Research of Servo Control with Microcontroller
Authors: Zhan Jiarui
Published: October 2022

Servos are widely used in aeromodelling and other model sports as a device that receives PWM signals to drive the rudder surface by controlling elements such as the transmission rod. By referring to previous experiences in developing quadruped robots and reviewing relevant books and papers, this essay summarizes the main methods of controlling a servo with a microcontroller. This will help the beginner in rudder control to acquire the relevant knowledge.
Study on photothermal coupling of COB lamp belt
Authors: Jin Dezhi , Shen Bangxing , Li Yuefeng , Lv Ruibo , Zou Jun , He Yi , Su Xiaofeng , Jin Weigang , Zhang Xinfeng
Published: October 2022

With the rapid development of LED technology, the lighting effect of LED lamp belt in the atmosphere lamp has been unable to meet the needs of the modern market, and the COB lamp belt has gradually entered the public field of vision due to its advantages of high light uniformity, low junction temperature and large luminous Angle. In this paper, the stability, light uniformity, junction temperature and other performance of the two kinds of lamp belt under different color temperature and different power were analyzed by setting contrast experiment. It was found that LED lamp belt had uniform light and poor heat dissipation effect due to chip distribution characteristics, and it would accumulate a lot of heat and appear color shift phenomenon when continuously lit. The COB lamp belt can not only maximize the heat dissipation performance of the substrate, but also achieve more uniform light distribution by the way of multi-chip arrangement. The relationship between the thermal performance and chip spacing is analyzed by optimizing the design, which plays a guiding role in the actual production of the lamp belt
Research on Maintenance Process Optimization of GW4-126DW Disconnecting Switch
Authors: Pei Ying , Niu Lin , Wang Shitao , Li Haifeng , Yin Qinghua , Gao Nannan , Ma Mengchao , Ai Ye
Published: October 2022

GW4-126DW disconnecting switch is a kind of switchgear commonly used in substations. When the disconnecting switch has defects or failures, it needs to be repaired. In this paper, the comparative analysis, system sorting, and summarization are used to optimize the maintenance process of the GW4-126DW disconnecting switch. After optimization, the overhaul process includes inspection before overhaul, dismantling of disconnecting switch, troubleshooting and elimination of defects, assembly and debugging, and inspection after overhaul. The research results have been applied to practice exercises for students majoring in electrical engineering. It has been proved that the maintenance process has clear logic, comprehensive operation steps and good practicality.
GSAIC: GeoScience Articles Illustration and Caption Dataset
Authors: Shi Rui
Published: October 2022

The scientific investigation of geoscience includes data collection, sample classification and semantic, consisting of a large number of images. An image-text search model that can well assist the research work of geoscience. However, the existing image-text datasets are mainly in the field of daily life and lack academic image-text datasets. In order to help geoscience researchers to investigate through the image and text, and to provide a new benchmark for researchers in the fields of data mining and information retrieval, this paper proposes a novel parallel material of geoscience academic illiustrateion and caption (GSAIC) based on GAKG, which contains over 900,000 illustrations of earth science papers and the corresponding captions. GSAIC filters out high-quality illustrations and captions through a classifier, and with the support of experts annotations. The GSAIC will support several tasks Including text search for images, retrieving corresponding images or papers based on academic image descriptions and academic illustration classification tasks, for geoscience scenarios Finally, both the GSAIC benchmark and classifier are publicly accessible.
Analyzation and application of PyMC3
Authors: Lei Zhenghong
Published: October 2022

This article studies and analyzes the data of “student study hour”. The purpose of this article is to analyze the relationship between students' learning hours and the score. Data analysis involves machine learning and algorithms. Therefore, these two parts and their related knowledge need to be learned and mastered. In the following part, the article will first introduce the utilization methods, which are machine learning, Bayesian method and PyMC3. Then, the article introduces the details of the analysis steps for the “student study hour” data. The conclusion will be presented at the end of the article, which concludes the linear relation of the data, and the pros and cons of PyMC3.
Task Allocation and Traffic Route Optimization in Hybrid Fire-fighting Unmanned Aerial Vehicle Network
Authors: Lan Kaixin , Duan Bohao , Qiu Shichao , Xiao Yang , Liu Meng , Dai Haocen
Published: October 2022

With the increase of extreme weather conditions in the world, the probability of forest fires is increasing. How the forest fire management decision-making system can monitor and control the fire quickly and effectively is the key of forest fire fighting work. This paper uses SSA drones carrying high-definition and thermal imaging cameras and telemetry sensors in conjunction, as well as Repeater drones used to greatly expand the frontline low-power radio range, to support fire management decision-making systems. At the same time, explore a drone cooperation plan to deal with different fire terrains and different scales of fire conditions. The aim of this paper is to improve the existing fire management decision system in order to quickly respond to the emergency fire. Research object for the Australian state of Victoria on October 1, 2019 to January 7, 2020 wildfires, explore SSA drones and Repeater drones in the application of the forest fire, ensure that fire management decision-making system to provide the optimal number deployment scheme of fire task quickly and efficiently, and achieve the maximum efficiency and economic optimal compatibility.
Efficient-VDSR Network for Super-Resolution
Authors: Chen Xi
Published: October 2022

Super-resolution image processing is an important research topic in the field of image processing. The exploration in this paper comes from the use of VDSR network, which can improve the learning rate by only detecting and learning the residuals since the difference between low-resolution and high-resolution images lies more in the high-frequency detail part. Increasing the depth of the network can significantly improve the learning rate and further affect the final rendering of the image, but the increase of weight layers also increases the number of iterations and training time. This paper intends to reduce the number of iterations by decreasing the number of weight layers and correspondingly shorten the training time of the model. Then, we create low-resolution images and improve the resolution of the images by using bicubic interpolation method and the trained network respectively, and then obtain the evaluation data of the image quality by final visualization and quantitative comparison. The results show that reducing the number of weight layers still leads to a high accuracy of the images and will reduce the number of iterations and time accordingly.
Effect of Gadolinium Orthovanadate Nanoparticles on Male Rabbits' Reproductive Performance under Oxidative Stress
Authors: Koshevoy Vsevolod , Naumenko Svitlana , Skliarov Pavlo , Syniahovska Kateryna , Vikulina Galina , Klochkov Volodymyr , Yefimova Svitlana
Published: October 2022

Oxidative stress as a leading factor of male infertility requires correction with modern pharmacological agents, particularly redox-active nanoparticles, to improve sperm quality and hormonal balance. The current experimental study aimed to investigate the effect of orthovanadate nanoparticles of rare earth elements, particularly Gadolinium, with pronounced redox properties on the reproductive function of male rabbits under oxidative stress. A total of 36 mature male Hyla rabbits were divided into three groups of intact control (n = 12) and two experimental groups, including rabbits ubder oxidative stress (n = 12), induced by the introduction of tert-Butyl hydroperoxide, and those under oxidative stress plus hydrosol of gadolinium orthovanadate nanoparticles (NPs, n = 12) intake for 14 days. There were four rabbits per three replicates in each group. Animals of all groups were kept on the same diet and had free access to water. The use of NPs led to an improvement in sperm quality indicators. There was an improvement in motility and ejaculate volume indicators (by 14.6% and 39.2%, respectively), a reduction of the content of morphologically abnormal sperm by 26.7%; normalization of sex hormones, an increase in the level of total testosterone (by 113%) with a decrease in 17-β-estradiol (by 16.5%). This sex hormones improvement led to an increase in the androgen saturation of the rabbit’s body (free androgen index at the end of the experiment was 36.5%). The obtained changes were accompanied by a decrease in the oxidative load, as evidenced by a reduced content of diene conjugates and thio-barbituric acid-reactive compounds in the blood serum of rabbits by 30.4% and 26.8%, compared to the control. At the same time, there was an increase in the antioxidant potential, especially its glutathione link – the activity of glutathione peroxidase and glutathione reductase (by 42.5% and 34.2%, respectively), and the content of reduced glutathione increased by 62.3%, compared to the indicators before the introduction of NPs. The results of the study confirmed the effectiveness of using gadolinium orthovanadate NPs to correct the reproductive function of males under oxidative stress.
PENGARUH BAURAN PEMASARAN TERHADAP PENINGKATAN VOLUME PENJUALAN DI BEGOS (BEBEK GOYANG SULAWESI) KOTA KENDARI
Authors: Zainuddin Muh. Zabir , M. Suyuti H. , Sari Anggit Arum
Published: October 2022

This study aims to determine the effect of marketing mix consisting of product, price, place, and promotion partially on sales volume increase in Begos in Kendari City, and to determine the effect of marketing mix consisting of product, price, place, and promotion simultaneously on sales volume increase in Begos in Kendari City. Methods used in this research are qualitative and quantitative.Data analysis tool used multiple linear regression using SPSS 20. The results of this study state that: simultaneously the marketing mix variable consisting of product, price, place, and promotion have a significant effect on sales volume increase in Begos in Kendari City. Product and place have a significant effect on sales volume increase in Begos in Kendari City. Price and promotion have no significant effect on sales volume increase in Begos in Kendari City.
PENGARUH PENJUALAN SECARA ONLINE TERHADAP MINAT BELI MASYARAKAT KOTA KENDARI
Authors: Zainuddin Muh. Zabir , Destiani Tina , Manan La Ode Abd.
Published: October 2022

The purpose of this study is to determine whether online sales have a significant effect on people's interest in buying Syar'i hijab clothing products at the “Emmy Hijabku” Clothing Store Kendari.The problem in this study is whether online sales have a significant effect on people's interest in buying Syar'i hijab fashion products at “Emmy Hijabku” Clothing StoreBy using a simple linear regression equation with the formulation Y = a +bX the results of the data analysisobtained Y = 8,071 + 0.640X. From the results of the study found that online syar'i hijab sales variables significantly influence the buying interest of the people in Kendari.It simply can be seen from a significant online sales label of 0.001, which means smaller than the significant level used is 0.05 and can be seen also from t-count with a value of 3,656 which means t-count is greater than t-table which is 0.681.
ANALYSIS OF DAIHATSU XENIA'S CAR MARKETING MIX STRATEGY IN INCREASING SALES VOLUME AT PT. KHARISMA SENTOSA IN KENDARI CITY
Authors: Hamyat Hasby , . Suharlian , Sugandi Ilham
Published: October 2022

The purpose of this research is to find out whether the marketing strategy is the marketing mix which consists of products, prices, promotions, places, people, processes and physical evidence applied by PT. Kharisma Sentosa Kendari can increase the sales volume of Daihatsu Xenia cars. This research is a qualitative study using a phenomenological approach, data collection using observation interview techniques with samples of employees and customers of PT. Kharisma Sentosa Kendari Branch. The results showed that the marketing strategy adopted by PT. Kharisma Sentosa Kendari in the form of a marketing mix which consists of products, prices, promotion of places, people, processes, and physical evidence has an impact on increasing Daihatsu Xenia's sales. For PT. Kharisma Sentosa Kendari, you should pay more attention to the existing HR resources that are friendly and agile in offering products to customers will provide additional value so that customers are affected to buy Daihatsu Xenia cars at PT. Kharisma Sentosa Kendari Branch.
PENGARUH STORE ATMOSFER TERHADAP KEPUTUSAN PEMBELIAN DI MEZZO COFFE & BISTRO KENDARI
Authors: Titop Herman , Manggau Richar Heser , . Safuruddin
Published: October 2022

This study aims to to know and to analyze do store the atmosphere influential of the decision purchases inMezzo Coffe& Bistro Kendari. Types of data in this research is primary data.The subject of this research is 20 samples of people are customersMezzo Coffe& Bistro Kendari. Data was gathered using a questionnaire.The data collected is processed using software application spss.This study using simple linear regression analysis and tests partial ( t ). The results of the study in full shows that store the atmosphere have had a positive impact of the decision of purchases inMezzo Coffe& Bistro Kendari." store the atmosphere would increase the purchase decision , with the results of testing based on test as much as thitung>ttabel namely5.479> 1.7340.000 significance and value of .
PENGARUH STORE ATMOSPHERE TERHADAP KEPUTUSAN PEMBELIAN PADA RUMAH MAKAN KAMPUNG BAKAU KOTA KENDARI
Authors: Zainuddin Muh Zabir
Published: October 2022

Kendari city is one cities in Sulawesi tenggara. As the capital of the provibce which is now strating to develop, the pace of economic growth and changes in technology and information are getting faster. The needs and desires of consumers the kampung bakau restaurant is one of the culinary tours on the outskirts of the bay of kendari city which offers a variety of culinary delight. Even the location can be used as good spots for taking pictures. Such as the photo spot for the view of the Al-Alam mosque, the pride of the people of kendari city and Sulawesi Tenggara. Strore atmosphere that is comfortable with unique and attractive decoration will be the main attraction for a restaurant that makes consumers decide to visit a restaurant just because they like the store atmosphere and laugh. Therefore,culinary business people can design the restaurant’s store atmospherein such a way as to create a sense of comfort and security in the early stages of consumers so that consumers will make purchasing decisions. This study aims to determine whether store atmosphere has a positive and significant effect on purchasing decisions at the kampung bakau restaurant, kendari city. This study uses a simple linear regression data analysis technique using the SPSS version 23.0 for windows program. Determination of the number of sample through purposive sampling technique as many as 54 respondent. Analysis proves store atmosphere has a positive and significant effect on purchasing decisions.
PENGARUH PEMBERIAN REWARD TERHADAP KINERJA PADA KARYAWAN PT. MEGA AUTO CENTRAL FINANCE CABANG KENDARI
Authors: Thomas Alfin
Published: October 2022

This study aims to examine and explain the effect of giving rewards on the performance of employees of PT. Mega Auto Central Finance. The object of this research is limited to employees of PT. Mega Auto Central Finance Kendari Branch. Determination of the sample using the census method. The sample in this study were 38 employees. Data collection was done by using a questionnaire.The results of this study indicate that the reward variable has a positive and significant effect on employee performance.Employee performance can be improved if an employee gets a reward from the company.Rewards can affect employee performance, because rewards will satisfy a number of needs that employees are trying to fulfill through their choices of work-related behavior so that when employee satisfaction is met, their concern for work will increase.
PENGARUH KUALITAS LAYANAN TERHADAP KEPUASAN KONSUMEN (STUDI MINI MARKET ALFA MIDI KECAMATAN RANOMEETO) KABUPATEN KONAWE SELATAN
Authors: Sahyunu Sahyunu , Juli Haspi , Titop Herman
Published: October 2022

Pada era bisnis saat ini, persaingan semakin meningkat. Persaingan ini menuntut para pelaku bisnis untuk mampu memaksimalkan kinerja perusahaannya agar dapat bersaing di pasaran. Perusahaan harus berusaha keras untuk mempelajari dan memahami kebutuhan dan keinginan pelanggannya. Perusahaan harus menempatkan orientasi pada kepuasan pelanggan sebagai tujuan utama Persaingan dari pelaku bisnis sendiri juga menjadi sangat tajam, baik dipasar domestik maupun dipasar internasionl. Pelaku bisnis harus mampu memberikan kepuasan kepada pelanggan, pelayanan produk yang lambat bisa membuat pelanggan tidak puas, walaupun dengan tingkatan yang berbeda. Konsumen memang seharusnya dipuaskan karena mereka merupakan pemain utama dalam dunia bisnis. Penelitian ini bertujuan untuk mengetahui pengaruh kualitas layanan terhadap kepuasan konsumen Mini Market Alfa Midi Kecamatan Ranomeeto Kabupaten Konawe Selatan. Penentuan jumlah responden penelitian ini menggunakan purposive sampling di mana jumlah sampel penelitian ini yaitu 50 responden. Hasil penelitian ini menunjukan bahwa kualitas layanan berpengaruh positif dan signifikan terhadap kepuasan konsumen Mini Market Alfa Midi Kecamatan Ranomeeto Kabupaten Konawe Selatan.
Analisis Kinerja Keuangan Alokasi Dana Desa
Authors: Manan La Ode ABdul , Djauhar Asri , Nurlela Nurlela
Published: October 2022

Financial Performance Analysis of Village Fund Allocation (Study in Lahunggumbi Village, Pondidaha District, Konawe Regency). This study aims to determine how well the financial performance of village fund allocations is based on the effectiveness ratio and growth ratio in Lahunggumbi Village, Pondidaha District, Konawe Regency. The type of research used in this research is quantitative. The data processed is the Village Fund Allocation Financial Report in the Village Revenue and Expenditure Budget from 2018 to 2020. The data collection techniques used are documentation techniques and library techniques. The data analysis technique used in this research is quantitative with the formula: Effectiveness Ratio and Growth Ratio. The results showed that in general the financial performance of the Lahunggumbi Village Government, Pondidaha District, Konawe Regency was good in managing the Village Fund Allocation finance. This can be seen from the calculation results of the Effectiveness Ratio categorized as Effective or Good, because the average effectiveness is 100%. While the Growth Ratio grew positively or well, because the average Village Fund Allocation Income Growth Ratio was 18,4% and the Village Fund Allocation Expenditure Growth Ratio was 18,4%.
DETEKSI DINI INGATAN (MEMORI) PADA LANSIA DENGAN MENGGUNAKAN SHORT PORTABLE MENTAL STATUS QUESTIONNAIRE (SPMSQ) DI KAMPUNG BELENGAN KECAMATAN MANGANITU
Authors: Pangandaheng Nansy Delia , Medea Gitalia Putri
Published: October 2022

Abstrak: Perkembangan memori pada lansia dapat mengalami kemunduran terutama dalam perkembangan kemampuan mental, termasuk kehilangan memori, disorientasi dan kebingungan. Penurunan fungsi kognitif yang terjadi pada lanjut usia dapat berlanjut menjadi gangguan demensia vaskuler maupun alzheimer disease apabila tidak ditangani dengan baik. Tujuan PKMS ini yaitu mengetahui fungsi kognitif pada lanjut usia. Kegiatan penyuluhan dilakukan dari rumah ke rumah hal ini dilakukan karena pandemi Covid-19, dimana tim pengabdian mengunjungi rumah-rumah lansia yang tinggal dikampung Belengan Kecamatan Manganitu. Deteksi dini ingatan dilakukan dengan menggunakan Short Portable Mental Status Questionnaire dan penyuluhan kesehatan resiko terjadinya demensia pada lansia. Dari 10 orang lansia yang dilakukan pemeriksaan melalui SPMQ terdapat 7 orang lansia memiliki kemampuan mengingat dengan baik, 2 orang mengalami gangguan mengingat ringan dan 1 orang lansia mengalami gangguan mengingat sedang.

 

Abstract: The development of memory in the elderly can experience a decline, especially in the development of mental abilities, including memory loss, disorientation, and confusion. The decline in cognitive function that occurs in the elderly can progress to vascular dementia and Alzheimer's disease if not treated properly. The purpose of this PKMS is to know cognitive function in the elderly. Counseling activities were carried out from the house to house, this was done because of the Covid-19 pandemic, where the service team visited the homes of the elderly who lived in Belengan village, Manganitu District. Early detection of memory is carried out using the Short Portable Mental Status Questionnaire and health education on the risk of dementia in the elderly. Of the 10 elderly people who were examined through SPMQ, 7 elderly people had good memory skills, 2 people had mild memory problems and 1 elderly had moderate memory problems.
GERAKAN LANJUT USIA SADAR COVID-19 DI POSYANDU LANSIA DESA PEMPALARAENG KECAMATAN KENDAHE KABUPATEN KEPULAUAN SANGIHE
Authors: Kalengkongan Detty Jeane , Tinungki Yeanneke Liesbeth
Published: October 2022

Dalam UU Kesehatan. No 23 tahun 1992, pasal 19ayat 1 tentang Kesehatan manusia usia lanjut perlu mendapatkan perhatian khusus dengan tetap dipelihara dan ditingkatkan agar selama mungkin dapat hidup secara produktif sesuai dengan kemampuannya sehingga dapat ikut serta berperanaktif dalam pembangunan.  Dengan adanyan pandemic Covid-19 yang merupakan ancaman bagi keselamatan lansia sebab efeknya akan lebih berbahaya atau bahkan fatal bila terjadi pada orang lansia, ibu hamil, orang yang memiliki penyakit tertentu, perokok atau orang yang daya tahan tubuhnya lemah. Upaya untuk mencegah penyebaran virus Corona adalah untuk mematuhi protokol kesehatan, namun hal ini belum memasyarakat sampai di wilayah pedesaan termasuk lansia. Tujuan kegiatan pelaksanaan pengabdian adalah untuk meningkatkan pengetahuan tentang Covid-19, termasuk cara penularannya serta manfaat dari pemberian vaksinasi. Metode yang digunakan yaitu penyuluhan/sosialisasi, dilanjutkan dengan pemeriksaan kesehatan  berupa pemeriksaan fisik, pemeriksaan tekanan darah, Saturasi Oksigen, pemeriksaan  kimia darah yang terdiri dari Cholesterol, Asam Urat dan Gula darah. Hasil yang dicapai pada pengabdian ini yaitu lansia dapat mengerti dan memahami tentang materi yang disampaikan. Dari jumlah lansia yang hadir sebanyak 26 orang semuanya dilakukan pemeriksaan dan hasil pemeriksaan yang tidak normal diedukasi untuk melakukan pemeriksaan lebih lanjut disarana kesehatan.

 

 

In the Health Act. 23 of 1992, article 19 paragraph 1 concerning the health of elderly people, it is necessary to pay special attention to the health of the elderly by maintaining and improving them so that as long as possible they can live productively according to their abilities so that they can take an active role in development. The Covid-19 pandemic is a threat to elderly safety because the effects will be more dangerous or even fatal if it occurs in the elderly, pregnant women, people who have certain diseases, smokers, or people whose immune systems are weak. Efforts to prevent the spread of the Coronavirus adhere to health protocols, but this has not yet been popular in rural areas, including among the elderly. The purpose of the service implementation activity is to increase knowledge about Covid-19, including how it is transmitted and the benefits of giving vaccinations. The method used is counseling/socialization, followed by health checks in the form of physical examinations, blood pressure checks, oxygen saturation, and blood chemistry test consisting of cholesterol, uric acid, and blood sugar. The results achieved in this service are that the elderly can understand the material that has been presented. Of the number of elderly who attended as many as 26 people, were examined and the results of abnormal examinations were educated to carry out further examinations in health facilities.
PELATIHAN DAN PENDAMPINGAN PEMBESARAN IKAN NILA (Oreochromis niloticus) SISTEM INTENSIF DI KELOMPOK PEMBUDIDAYA ‘LUMBENA” KAMPUNG KUMA 1 KECAMATAN TABUKAN TENGAH
Authors: Manganang Yessi
Published: October 2022

Abstrak: Permintaan kebutuhan ikan air tawar khususnya ikan nila (Oreochromis niloticus) mengalami kenaikan diiringi oleh peningkatan tingkat konsumsi ikan. Kampung Kuma 1 adalah kampung yang terletak di Wilayah Kecamatan Tabukan Tengah, merupakan salah satu kampung yang melakukan kegiatan usaha budidaya ikan nila. Budidaya yang dilakukan masih menerapkan sistem konvensional, sehingga untuk meningkatkan hasil produksi, salah satu cara adalah dengan menerapkan budidaya ikan secara intensif. Pemeliharaan ikan dapat dilakukan dengan padat tebar tinggi dan menggunakan pakan dengan protein tinggi. Kegiatan PKMS dilakukan untuk memberikan penyuluhan dan pelatihan kepada masyarakat tentang teknik budidaya ikan nila sistem intensif. Peserta kegiatan adalah masyarakat pembudidaya ikan “Lumbena” dan pemerintah Kampung. Pelaksanaan kegiatan pada bulan juli-Agustus 2021 dengan metode partisipasi aktif dari pembudidaya dan pendampingan tim PKMS. Materi kegiatan meliputi teknik pembesaran ikan meliputi penyiapan wadah, penyiapan benih ikan, pengontrolan kualitas air, pemantauan hama dan penyakit ikan, pemberian pakan, pemanenan. Masyarakat sangat antusias mengikuti kegiatan ini dan dari kegiatan ini masyarakat bisa memperoleh tambahan pengetahuan dan ketrampilan dalam melakukan kegiatan budidaya ikan.

 

Abstract: The demand for freshwater fish such as tilapia (Oreochromis niloticus) in the Sangihe Islands has increased along with an increase in fish consumption. Located in the Central Tabukan district, Kampung Kuma I was one of the villages whose community had been actively engaged in tilapia fish farming for years. However, to increase tilapia production in the village, an intensive fish farming method, in place of the currently applied conventional technique, was urgently needed. The fish rearing could be achieved by using high stocking density and fish feed containing high protein. This community service (known also as PKMS) aimed to provide counseling and training on intensive techniques in tilapia cultivation to the community in the village. The participants of the PKMS were a fish farming community named "Lumbena" and members of the local/village government. The PKMS was conducted from July to August 2021 through mentoring by the PKMS team and active participation from the local fish farmers. The counseling and mentoring topics for the community service covered a wide range of fish rearing techniques such as preparation of fish containers, fish seeds, water quality control, fish pest, and disease monitoring, fish feeding, and fish harvesting. The community actively participated in community service and gained the knowledge and skills required for fish farming.
PENGUATAN USAHA PENGASAPAN IKAN MELALUI TEKNOLOGI PENGEMASAN PRODUK
Authors: Rieuwpassa Frets , Berhimpon Siegried , Pumpente Obyn Imhart
Published: October 2022

Masalah utama yang sering dihadapi oleh pengolah ikan asap “Kelompok Berkat” di kampung Petta adalah produk yang dihasilkan tidak dapat bertahan lama atau memiliki umur simpan yang rendah yaitu hanya 3 hari. Hal ini disebabkan karena produk tersebut belum dikemas sehingga produk mudah dihinggapi lalat dan kontaminan lainnya baik dari pekerja maupun peralatan yang digunakan. Keadaan ini menyebabkan nilai jual produk rendah, dan makin lama disimpan harganya makin menurun. Karena itu dirasa sangat perlu dilakukan penyuluhan dan pelatihan tentang cara pengemasan produk ikan asap. Tujuan dari pengabdian ini ialah melakukan penyuluhan tentang 1. fungsi wadah kemasan untuk menjaga kualitas, keamanan, dan masa simpan produk serta menambah daya tarik produk 2. memperkenalkan jenis-jenis wadah kemasan, dan 3. pemasaran produk yg sudah dikemas secara online berbasis media sosial. Tahapan pelaksanaannya meliputi: survey, penyuluhan dan pelatihan tentang pengemasan produk, pemberian bantuan, pendampingan dan evaluasi. Pemberian materi pengemasan diikuti dengan baik oleh kelompok berkat. Kelompok sangat antusias untuk menerima materi yang diberikan. Bantuan yang diberikan serta demo penggunaan alat vakum sealer diikuti dengan baik dan benar oleh kelompok. Kegiatan ini juga telah dipublikasikan pada media online (sastalpos.com).

 

The main problem that is often faced by the "kelompok Berkat" smoked fish processor in Petta village is that their products cannot last long or has a short shelf life of only 3 days. This is because the product has not been packaged so that the product is easily infested by flies and other contaminants from both the workers and the equipment used. This situation causes the selling value of the product to be low, and the longer it is stored, the lower the price. Therefore, it is necessary to conduct training on how to package smoked fish products. The purpose of this service is to provide training about 1. the function of packaging containers to maintain product quality, safety, and shelf life and increase product attractiveness 2. introduce types of packaging containers, and 3. marketing products that have been packaged by online based on social media. The stages of implementation include: surveys, counseling and training on product packaging, providing assistance, mentoring and evaluation. The distribution of packaging materials was well followed by the kelompok Berkat. The group was very enthusiastic to receive the material given. The assistance provided as well as a demonstration of the use of the vacuum sealer tool were followed properly and correctly by the group. This activity has also been published on online media (sastalpos.com).
Root canal morphology of 1316 premolars from Brazilian individuals: an in vivo analysis using cone-beam computed tomography
Authors: Lemos Marília , Coutinho Thaïs , Perez Alejandro , Medeiros Thamires , Marceliano-Alves Marília , Alves Flávio
Published: October 2022

The aim of this study was to investigate the internal root canal anatomy of maxillary and mandibular premolars in a Brazilian subpopulation, in order to establish the prevalence of the different configurations proposed by Vertucci. Three hundred and ninety-eight cone-beam computed tomography scans were collected from a private imaging clinic database in Rio de Janeiro, including 217 maxillary and 226 mandibular scans. A total 1316 premolars (594 maxillary and 722 mandibular) were evaluated using an image viewer, and classified according to Vertucci. Two calibrated examiners determined the frequency of each morphological Type. A third examiner reviewed discordant cases. The Kappa test was applied to verify inter-rater agreement, and Fisher’s Exact Test to verify gender-related differences. The most frequent root canal configurations of maxillary first and second premolars were Type IV (73.86%) and Type I (47.18%), respectively. Type I was the most prevalent in mandibular first and second premolars (80.59% and 95.86%, respectively). Only Types I and VIII presented a statistically significant difference between sexes. Type I was more frequent in females and Type VIII in males. A highly significant frequency of Type I was found in both mandibular first and second premolars, whereas the most frequent maxillary premolar root canal configuration was Type IV for first premolars and Type I for second premolars.
Fluoride and silver ion concentrations and pH in silver diamine fluoride solutions from Argentina
Authors: Rossi Glenda , Valadas Lidia , Squassi Aldo
Published: October 2022

The aim of this study was to measure the fluoride (F) and silver (Ag) ion concentration and the pH, over time, of 2 solutions of 38% silver diamine fluoride (SDF) produced in Argentina. The brand Fluorsilver® was established as Group 1 (G1) (Densell), and the brand FAgamin® (Tedequim) as Group 2 (G2), each with two different lots. The following were determined at time 0 (t0) and 30 days after opening (t30): a) fluoride concentration (w/v) by visible spectrophotometry b) Ag content (w/v) by atomic absorption spectrophotometry c) pH. Results: The data in the freshly opened bottles were for G1 lot1/lot2: a) 0.96/1, b) 8.3/7.8, c).11.5/11.3; G2 lot1/lot2: a) 11.5/9.9, b) 39/39, c) 7/6,9; and after 30 days, G1 lot1/lot2: a) 0.85/0.81, b) 7.2/8.2, c) 11.3/11.6; G2 lot1/lot2: a) 9.35/8.43, b) 38/38, c) 7.6/7.6. Conclusion In relation to the expected values (5.0-5.9% fluoride and 24.4-28.8% silver), the average concentration of fluoride and silver ions was lower for G1, but higher for G2. The pH was alkaline for G1 and neutral for G2. Over the 30 days, the content of fluoride and silver tended to decrease.
CONCEPTUAL FRAMEWORK FOR AIRPOWER TO COUNTER NON-TRADITIONAL SECURITY THREATS
Authors: Bhatti Amjad Mahmood
Published: October 2022

The early theorists had conceived airpower to break the adversary's will and achieve decisive impact; however, technological deficiencies and weak strategies prevented airpower from doing so. Later, especially in the second half of the 20th century, advancements in technology and the advent of new concepts developed airpower as a military tool of the first choice to achieve strategic advantages. Traditionally, states remained the referent objects and a prime focus for national security, but post-cold war developments witnessed the emergence of a non-traditional security paradigm, increasingly making individuals referent objects of security. This security dimension primarily affected individuals and ideational aspects and led to the developing of a new identity-based construct with increasing political, economic, military, environmental, and societal influences. This paper highlights that despite the remarkable advancements in airpower technology and its ever-increasing role as a critical military instrument, its effectiveness in dealing with security threats and achieving a decisive victory in situations complexed by non-traditional threats remains ambiguous. Considering terrorism as a social construction allows investigation into unthinkable policies to counter it. Nevertheless, the main objective of the policy perhaps can be the deconstruction of the undesirable construct whereby airpower, enabled with modern technology, can act as a leading military component.
 
Bibliography Entry
Bhatti, Amjad Mahmood. 2022. "Conceptual Framework for Airpower to Counter Non-traditional Security Threats." Margalla Papers 26 (1): 47-60.