bluuebunny/crossref_metadata_2025 huggingface dataset:
CYP450 Metabolism of a Semisynthetic Naphthoquinone, an Anticancer Drug Candidate, by Human Liver Microsomes
Authors: Costa Edna , Carrão Daniel , Bucci Jade , Oliveira Anderson , Machado Tallita , Ferreira Vitor , Lima Émerson , Vasconcellos Marne , Magalhães Igor
Published: February 2022

CNFD (6b,7-dihydro-5H-cyclopenta[b]naphtho[2,1-d]furan-5,6(9aH)-dione) is a semisynthetic naphthoquinone derived from lawsone that has cytotoxic action in different tumor lines and anticancer activity in vivo. Therefore, this molecule is a relevant candidate for drug development, but there is still no information on its human metabolism and systemic elimination. This study aimed to investigate the in vitro metabolism of this naphthoquinone by human liver microsomes. Initially, in order to determine the in vitro enzymatic kinetic parameters, a high performance liquid chromatography (HPLC) method to quantify the CNFD was developed and validated. In addition, the enzymatic kinetic data, the predicted pharmacokinetic in vivo parameters and the phenotyping study were presented. The main metabolism sites and metabolites have been suggested in silico. The developed HPLC method was linear, reproducible, selective, accurate, and stable. The enzymatic kinetic parameters revealed a sigmoidal profile. In vitro to in vivo extrapolation hepatic metabolic clearance was 10.39 mL min-1 kg-1 protein and the liver extraction rate was 51%. The clearance in vivo associated with a hepatic extraction ratio indicates that the hepatic metabolism is the main route of elimination. Although all cytochrome P450 enzymes evaluated metabolized CNFD, CYP2C9 and CYP3A4 showed higher metabolic capacity. For the first time, metabolism studies of CNFD were demonstrated.
Brain Building Opportunities in Senior Preschoolers by Means of Psychological and Pedagogical Support
Authors: Artyuhova Tat'yana , Federova Elena
Published: February 2022

This experimental study featured the process of brain building in senior preschoolers, namely the characteristics of verbal and nonverbal thinking at this stage of ontogenesis. The authors substantiated the possibilities of psychological and pedagogical support for cognitive development. Mental operations were tested using standard psychological diagnostics. The article covers some psychological and pedagogical theories of brain development in preschoolers. In visual-figurative forms, the development level of mental operations proved to be more expressive than in verbal and logical forms. The research revealed various possibilities of targeted development of verbal and nonverbal brain building components in senior preschoolers, as well as the forms and methods of psychological and pedagogical support it requires. The author believes that traditional educational practices should be reformed. Organized educational environment, productive activities, and games develop cognitive interests and curiosity and catalyze the development of activities initiated by the child. Experimental data proved the effectiveness of specially created programs of psychological and pedagogical support for the verbal and non-verbal cognitive development of preschoolers.
Cognitive Development in Primary School Children with Speech Problems
Authors: Semenova Marina
Published: February 2022

This present research featured brain building in primary school students with speech problems. The article raises the issues of inclusive education, defines the concept of the so-called general speech underdevelopment, and describes its levels. The author studied various theoretical approaches to the problem in question and the cognitive development in children of primary school age. An ascertaining and formative experiment made it possible to study the specifics of mental operations in children with speech developmental issues. A number of non-verbal tests revealed poor formation of mental operations. The children found text-related tasks especially difficult and required additional explanations and visual examples, which was a clear sign of poor abstract thinking. The article introduces some ideas about correctional and developmental extracurricular activities that improve such cognitive skills as analysis, synthesis, and coherent writing.
Legal Goal-Setting and the Function of Judicial Policy at the Stage of Consolidation of the Soviet Legal Regime
Authors: Gavrilov Stanislav , Velichko Aleksey
Published: February 2022

he present research featured the regulatory legal acts of 1917–1920 and the doctrinal foundations of justice during the formation of the Soviet political regime. The article concentrates on the problems of goal-setting of the Soviet legal system, the system of people's courts, and the crisis legislation of the period under review. The main functions of the judiciary system included: repressions; justice represented by people's courts; legislation; accessibility of justice; total involvement of workers in judicial duties; replacement of the system of criminal penalties with measures of peer pressure, and their effective implementation. The analysis showed that the legal goal-setting was performed empirically, depending on specific historical conditions. The main functions of administrative bodies and courts were deformed because no conditions for their implementation were provided for objective or subjective reasons. Only the repressive function was fully realized during the Civil War. The constituent norms of the Soviet legislation on the court contradicted with the legal realities of the era of civil confrontation.
Subtleties of Proceedings in the First Instance of the Commercial Court
Authors: Trezubov Egor
Published: February 2022

The article contains some comments on the legal positions stated in the Decree of the Plenum of the Supreme Court of the Russian Federation No. 46 dated December 23, 2021, as well as on novelties in the regulation of arbitration web conferences. The Decree points the participants of procedural relations to the need for conscientious implementation of their rights and obligations in the conditions of an adversarial process. It also indicates their obligation to apply the consequences of abuse of procedural rights. The emphasis on the risky nature of procedural relations stimulates the application of liability measures and encourages participants to exercise their rights and obligations. The categories of "other economic activity" and "dispute on the right to real estate" underlie the competence of arbitration courts but remain unclear. The author criticizes the decisions of the Plenum to lower the requirements for qualifications of legal representatives and formalize their powers in technical actions. The fact that a contractual representative has to apply for admission at each court session contradicts the principle of procedural economy and the legal nature of the procedural legal relationship. The article also reviews the amendments to the Arbitration Procedure Code of the Russian Federation in terms of online court sessions.
Sanitation planning for resettlement sites in Laos
Authors: Soudachanh Souphaphone , Langergraber Günter , Salhofer Stefan
Published: February 2022

Hydropower plants have been making both direct and indirect impacts on the environment and society on many levels in Laos as they require people who live in downstream and upstream areas to relocate to new resettlement sites. A sanitation planning process for resettlement sites in Laos is evaluated by an evaluating tool which has been developed according to three international sanitation planning guidelines, namely Community-Led Urban Environmental Sanitation Planning (CLUES), the Sanitation Safety Planning methodology by the WHO, and Sanitation 21. Four resettlement sites were selected, based on their differences in terms of project developers, scales, consultancy companies, and the number of people impacted. All four cases had positive performances in their project preparation and the implementation phases which showed a strong institutional arrangement and high engagement by the stakeholders. However, the technical planning phase was overlooked and given a low priority, the boundary of the systems was roughly defined, and there was no clear support to develop a treatment system for the reuse of wastewater, and no health risk assessment. We propose six concise sanitation planning steps and resource-oriented sanitation for resettlement sites which aim to support project developers' decision-making and planning for sanitation systems in resettlement sites.
Evaluation of the climate change impact on the intensity and return period for drought indices of SPI and SPEI (study area: Varamin plain)
Authors: Azizi Hamidreza , Nejatian Niloofar
Published: February 2022

In this study, to investigate the climate change effect on meteorological drought in the next three decades of Varamin plain, the EC-EARTH model was selected from the (AR5) report with the high performance of temperature and precipitation simulation compared to the base period under RCP scenarios and then by LARS-WG software was downscaled. In addition, (intensity-duration) and the return period of drought indices of Standard precipitation index (SPI) and Standardized precipitation-evapotranspiration index (SPEI) in annual time series were evaluated. Results illustrated that the seasonal precipitation pattern has changed, and mean temperatures will increase by 1.4 °C compared to the base period. The results of the drought assessment showed that the intensity of drought in the future compared to the base period based on SPI and SPEI increased by 8 and 28%, respectively, indicating that the SPEI was more severe in all three scenarios than the SPI. It can mainly be explained by the contribution and effect of increasing the average temperature along with precipitation in the SPEI. Also, the return period of severe droughts under the RCP8.5 scenario for SPEI in the base and future periods is 8 and 6 years, respectively, which indicates a decrease in the return period of severe droughts and an increase in dry years in the future.
Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid
Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy
Authors: Patil Prajakta Harish , Jagadish Puralae Channabasavaiah , Fatima Fajeelath , Birangal Sumit , Shenoy Gurupur Gautham , Rao Mahadev , Farooqui Junaid , Rastogi Himanshu , Sharma Tarun , Pinjari Jakir
Published: February 2022

Background and objective:

Concurrent usage of proton pump inhibitors and their effect on survival and
medication termination has been found in individuals receiving protein kinase inhibitor chemotherapy. To investigate
the drug-drug interaction mechanism between CDK inhibitors and proton pump inhibitors, the in-silico docking
approach was designed by applying computer simulation modules to predict the binding and inhibitory potential.

Method:

The interaction potential of proton pump inhibitors and CDK inhibitors was predicted utilising molecular
docking techniques that employed Schrödinger algorithms to capture the dynamics of the CYP450 enzyme-inhibitor
interaction between proton pump inhibitors and CDK inhibitors. Additionally, the human liver microsomes assay was
used to determine the in vitro half-maximal inhibitory concentration (IC50) of proton pump inhibitors and the inactivation
of CDK inhibitors via CYP3A4.

Results:

Proton pump inhibitors alter the conformation of the CYP3A4 and CYP2C19 enzymes and interact with the
heme prosthetic group, as determined by docking studies. It may result in the suppression of CDK inhibitors' metabolism
via competitive inhibition at the binding site of an enzyme. Omeprazole and rabeprazole both significantly block
midazolam's 1′-hydroxylation by CYP3A4 in vitro, with IC50 values of 9.86μM and 9.71μM, respectively. When
omeprazole and rabeprazole are co-incubated in human liver microsomes at a 30μM concentration equivalent to the
Cmax of omeprazole and rabeprazole, rabeprazole significantly prolongs the metabolic clearance of palbociclib,
whereas omeprazole affects the ribociclib CYP3A4-mediated metabolism.

Conclusion:

Using dynamic models, we determined that proton pump inhibitors such as rabeprazole and omeprazole
indeed have the potential to cause clinically significant drug-drug interactions with CDK inhibitors in the treatment
of estrogen receptor (ER) positive and HER2-positive breast cancer. As a result, it is suggested to use caution when
prescribing proton pump inhibitors to these individuals.
Cavernous Hemangioma of the Maxillary Sinus Masquerading Recurrent
Hemorrhagic Mass: Histological-Radiological Correlation and a Literature
Review
Authors: Baek Hye Jin , Kim Sungbin , Ryu Kyeong Hwa , An Hyo Jung , Joo Yeon-Hee
Published: February 2022

Background:

Sinonasal cavernous hemangioma is rare. To date, fewer than 20 cases have
been reported in the literature; however, they may be a source of recurrent epistaxis and masquerade of
a hemorrhagic mass on CT and MRI.

Case Report:

A 68-year-old woman was presented with recurrent epistaxis and progressive right malar
fullness. On rhinoscopy, a bulge lesion was observed with multifocal hemorrhagic and friable surfaces
in the right nasal cavity. CT and MRI demonstrated a well-defined mass in the right maxillary sinus
with inhomogenous T2 hyperintensity, hypointense septa, peripheral rim, and multiple papillary enhancement,
suggesting a recurrent hemorrhagic mass. The mass was excised endoscopically, and the
histologic diagnosis was cavernous hemangioma.

Conclusion:

Imaging studies, such as CT and MRI, are essential in making an accurate diagnosis of
cavernous hemangioma of the maxillary sinus. Endoscopic excision of the lesion can be curative.
Analisa Sebaran Banjir Akibat Keruntuhan Waduk Wadaslintang
Authors: Kurniyawan Roni Dwi , Hendrasari Ratna Septi
Published: February 2022

ABSTRACT A heavy rain that happened in upstream area caused the increasing of debit inflow into the reservoir. If debit inflow got into the reservoir was big, so that, it caused the water overflowing from the top of reservoir. Thus, it caused the reservoir collapse that made a flood. The objective of this research was to know the map of flood spread when the reservoir was collapse and to know the flood speed and time towards the downstream. The method used is unit hirograf in having the calculation by HSS Nakayasu and the next was taken model by software HEC-RAS 5.06. From the result obtained the conclusion that breaking reservoir in QPMF. The result of flood hirograf data in dam break location using HEC-RAS application in HEC-RAS was the deepest flood in 8,1 m with the fastest maximum speed in 8,17 m/s, and the time needed by the flood to DAS Wawar, downstream area was for 0,78 hour.ABSTRAKHujan yang terjadi pada daerah hulu dengan intensitas tinggi akan mengakibatkan peningkatan debit inflow yang masuk ke waduk. Apabila debit inflow yang masuk ke waduk besar maka dapat mengakibatkan meluapnya air melalui puncak bendungan. Hal ini dapat mengakibatkan terjadinya keruntuhan bendungan yang dapat menimbulkan bencana banjir. Tujuan penelitian ini adalah untuk mengetahui peta sebaran banjir saat bendungan runtuh dan mengetahui kecepatan dan waktu banjir tersebut mencapai ke daerah hilir. Metode yang digunakan adalah hirograf satuan dihitung dengan HSS Nakayasu dan selanjutnya dimodelkan menggunakan software HEC-RAS 5.06. Dari hasil penelitian diperoleh kesimpulan bahwa bendungan breaking pada saat QPMF. Hasil data hidrograf banjir pada lokasi dam break dengan aplikasi HEC-RAS pada saat QPMF adalah kedalaman banjir tertinggi sebesar 8,1 m dengan kecepatan maksimum tertinggi sebesar 8,17 m/dt., serta waktu yang dibutuhkan banjir untuk sampai ke daerah hilir DAS Wawar adalah selama 0,78 jam.
Perancangan Ulang Struktur Atas Gedung Kantor Otoritas Jasa Keuangan Surakarta Menggunakan Baja Konvensional
Authors: Pratama Muhammad Firdaus Willy , Hidayatullah Eka Faisal Nur
Published: February 2022

ABSTRACTThe purpose of this final project is to determine the dimensions of the profile, connection, deviation, and structure of the Surakarta Financial Services Authority Office Building. The research method used is the redesign of the upper structure of the Surakarta Financial Services Authority Office Building using conventional steel based on Indonesian National Standards. Based on the analysis and re-planning shows that the steel structure of the Surakarta Financial Services Authority Office Building meets the SCWB (Strong Column Weak Beam) concept. The profiles obtained are used for 7 types of beam components, namely B1 (IWF 350.350.14.22), B2 (IWF 350.350.19.19), B3 (IWF 350.350.12.19), B4 (IWF 350.350.16.16), B5 (IWF 300.300 . 10.15), B6 (IWF 300.3000.9.14), and B7 (IWF 250.250.14.14) as well as 8 types of column components, namely column K1 (IWF 400.400.20.35), K2 (IWF 400.400.18.28), K3 (IWF 400.400. 16.24 ), K4 (IWF 400.400.21.21), K5 (IWF 350.350.10.16), K6 (IWF 350.350.13.13), K7 (IWF 300.300.11.17), and K8 (IWF 300.300.15.15) which have a type of cross section that is compact and meet the requirements of the moment and shear ratio, flexible and shear control, as well as the safety factor in accordance with the requirements ABSTRAKPenelitian ini bertujuan untuk mengetahui dimensi profil baja, sambungan, simpangan, dan stabilitas struktur Gedung Kantor Otoritas Jasa Keuangan Surakarta. Metode penelitian yang digunakan ialah perancangan ulang struktur atas Gedung Kantor Otoritas Jasa Keuangan Surakarta menggunakan baja konvensional berdasarkan Standar Nasional Indonesia. Berdasarkan hasil analisis dan perencanaan ulang menunjukkan bahwa struktur baja Gedung Kantor Otoritas Jasa Keuangan Surakarta memenuhi konsep SCWB (Strong Column Weak Beam). Diperoleh profil yang digunakan pada komponen balok sebanyak 7 jenis yaitu balok yaitu balok B1 (IWF 350.350.14.22), B2 (IWF 350.350.19.19), B3 (IWF 350.350.12.19), B4 (IWF 350.350.16.16), B5 (IWF 300.300.10.15), B6 (IWF 300.300.9.14), dan B7 (IWF 250.250.14.14) serta komponen kolom sebanyak 8 jenis yaitu kolom K1 (IWF 400.400.20.35), K2 (IWF 400.400.18.28), K3 (IWF 400.400.16.24), K4 (IWF 400.400.21.21), K5 (IWF 350.350.10.16), K6 (IWF 350.350.13.13), K7 (IWF 300.300.11.17), dan K8 (IWF 300.300.15.15)  yang mempunyai jenis penampang kompak dan memenuhi syarat rasio momen dan geser, kontrol lentur dan geser, serta safety factor yang sesuai dengan persyaratan.
Магнитные свойства нанокристаллического материала на основе Bi-=SUB=-2-=/SUB=-Fe-=SUB=-4-=/SUB=-O-=SUB=-9-=/SUB=-
Authors: Бурьяненко И.В. , Семенов В.Г. , Ломанова Н.А. , Осипов А.В. , Волков М.П. , Плешаков И.В.
Published: February 2022

The magnetic characteristics of a nanocrystalline material based on bismuth ferrite Bi2Fe4O9 with 60±3 nm crystallites were studied. The obtained material demonstrates unusual magnetic properties, which are manifested in a significant increase in the value of magnetization in comparison with the data known from other works.
Влияние сильного статического электрического поля и нагрева на характеристики высокочастотного импеданса структур металл--сегнетоэлектрик--полупроводник
Authors: Белорусов Д.А. , Гольдман Е.И. , Чучева Г.В.
Published: February 2022

Studies have been carried out on the effect of heating and a strong field, but
pre-breakdown, effects on high-frequency characteristics of the impedance of heteroepitaxial structures Ni-Ba0.8Sr0.2TiO3-рSi with a ferroelectric thickness of 50 nm. It was shown, that regardless of the polarity of the field stress, characteristics shifted towards a positive bias, and the width of hysteresis loops decreased; plateau levels remained virtually unchanged. Heating up to 121°C led to a change in levels of the upper plateau of characteristics: for the capacity it decreased, and for the conductivity it increased; branches on the loop not only narrowed and shifted, but changed places in comparison with the original dependence (loop reverse). These results can be explained: under the field action, by the generation of additional electronic states, localized in the buffer layer at the Si-Ba1-xSrхTiO3 interface, and by heating, by the appearance of delay effects due to the development of fluctuation processes, underlying the smearing of the phase transition from ferroelectric to paraelectric condition.
Влияние поверхности и границ раздела на продольный тепловой транспорт в слоистых тонкопленочных структурах Si/Ge
Authors: Хомец А.Л. , Холяво И.И. , Сафронов И.В. , Филонов А.Б. , Мигас Д.Б.
Published: February 2022

One of the main approaches to increase the thermoelectric figure of merit of materials is to reduce their thermal conductivity and, in this respect, the surface and possible interfaces play an important role in low-dimensional structures. By means of nonequilibrium molecular dynamics simulations at 300 K we investigate the longitudinal phonon thermal conductivity in Si/Ge multilayered thin-film structures having sharp interfaces and (100), (110), (111) crystallographic orientations with respect to the number of Si/Ge periods (or film thickness) and in comparison with Ge films of equivalent thickness. It is shown that as the thickness of the Si/Ge layered film decreases from ~50 to 1 nm and heat flux propagates along the [110] direction, significant phonon-surface scattering occurs for the (100) orientation, which leads to a decrease in the phonon thermal conductivity by almost a factor of 4 (from 19.1 to 5.12 W/(m·K)) and to insignificant change (~ 22 ± 1 W/(m·K)) for the (110) and (111) orientations. In comparison with the Si/Ge films, the Ge films of equivalent thickness display a qualitative and quantitative agreement indicating the scattering of phonons at the Si/Ge interface to be balanced by the higher thermal conductivity of the Si layers.
A Food Poisoning Outbreak Caused by Shigella in Al-Mafraq, Jordan, in 2019
Authors: Alkhalili Mais
Published: February 2022

Background

On October 6, 2019, 55 residents of Bala'ama town in Al-Mafraq, Jordan, were admitted to the local health care center with symptoms of food poisoning.

Objective

This study aimed to identify the cause of the food poisoning outbreak.

Methods

This descriptive study is a cross-sectional study. Data were obtained from the Directorate of Communicable Diseases in the Ministry of Health. A total of 25 stool samples from patients and an additional 2 samples from workers in the restaurant were collected and tested. An environmental survey of the food and water was also conducted.

Results

The period of the outbreak was from October 6 to 10, 2019. The highest proportion of patients were children under 5 years of age. More females than males were affected. Stool test results were positive for Shigella sonnei in 15 samples and rotavirus in 7 samples. Chloride concentration was 0 in the water samples.

Conclusions

The food poisoning outbreak was caused by consumption of hummus from a neighborhood restaurant, which was contaminated with S. sonnei.
Immersive Virtual Reality–Based Cognitive Intervention for the Improvement of Cognitive Function, Depression, and Perceived Stress in Older Adults With Mild Cognitive Impairment and Mild Dementia: Pilot Pre-Post Study (Preprint)
Authors: Zhu KaiYan , Zhang QiongYao , He BingWei , Huang MeiZhen , Lin Rong , Li Hong
Published: February 2022

BACKGROUND

The incidence of dementia is increasing annually, resulting in varying degrees of adverse effects for individuals, families, and society. With the continuous development of computer information technology, cognitive interventions are constantly evolving. The use of immersive virtual reality (IVR) as a cognitive intervention for older adults with mild cognitive impairment (MCI) and mild dementia (MD) is promising, although only few studies have focused on its use.

OBJECTIVE

The Chinese virtual supermarket (CVSM) IVR system was developed to provide a comprehensive and individual cognitive intervention program for older patients with MCI and MD. The aim of this study was to explore the feasibility and clinical effectiveness of this 5-week IVR-based cognitive intervention.

METHODS

A pretest-posttest study design was conducted with 31 older adults with MCI and MD from August 2020 to January 2021. All participants participated in a 5-week immersive virtual cognitive training program using the CVSM system. Feasibility was assessed as the incidence and severity of cybersickness symptoms and participant satisfaction based on questionnaires conducted after the intervention. Clinical effectiveness was evaluated using neuropsychological assessments, including several commonly used measures of cognitive function, depression, perceived stress, and activities of daily living. Measurements were obtained at baseline and after the intervention period.

RESULTS

A total of 18 patients with MCI (mean age 82.94 [SD 5.44] years; 12 females) and 13 patients with MD (mean age 85.7 [SD 4.67] years, 10 females) participated in this pilot study. Both groups showed significant improvements in all cognitive function measurements (P<.001). The MD group had a significantly greater improvement in general cognitive function compared to the MCI group in Montreal Cognitive Assessment Scale, Symbol Digit Modalities Test, Shape Trail Test, and Auditory Verbal Learning Test. Furthermore, an intervention effect was observed in the improvement of perceived stress (P=.048 for MD group, P=.03 for MCI group ).

CONCLUSIONS

The use of the CVSM system may be effective in enhancing the cognitive function of patients with MCI and MD, including general cognitive function, memory, executive function, and attention. IVR technology enriches cognitive intervention approaches and provides acceptable, professional, personalized, and interesting cognitive training for older adults with cognitive impairment.

CLINICALTRIAL

ClinicalTrials ChiCTR2100043753; https://trialsearch.who.int/Trial2.aspx?TrialID=ChiCTR2100043753
Risk Perception about Communicable and Vector Borne Diseases in International Travelers at Islamabad International Airport, Pakistan. April to June 2021 / A Cross Sectional Study (Preprint)
Authors: Saeed Sara , Tahir Qandeel , Kawish Ayesha Babar , Malik Muhammad Wasif , Tahir Irfan , Khan Mumtaz Ali , Bushra Hina , Ikram Aamer
Published: February 2022

BACKGROUND

Travelers are always at risk of exposure to any new communicable or vector borne disease when they travel from one geographical area to another. This study was aimed to determine the risk perception about communicable and vector borne diseases among international travelers arriving to Islamabad from different regions of the world.

OBJECTIVE

Relatively little is known about how travelers know and perceive the health risks associated with travel and how they utilize preventive measures before and while traveling abroad. This study will assess the risk perception of international travelers about communicable and vector borne diseases which will help in decreasing global burden of diseases.

METHODS

426 participants were included through convenient sampling. Tool to collect information was an already validated Questionnaire. Chi square test was applied to find out any significant association between dependent and independent variables.

RESULTS

The level of risk perception was calculated by summating scores of knowledge, attitude and practices of international travelers regarding communicable and vector borne diseases, out of 426 respondents only (53 %) had a high risk perception whereas (47%) had a low risk perception. A significant association was found between level of risk perception and gender x2 20.9, P-value = 0.000, level of education x2 42.9, P-value = 0.000, nationality x2 7.5, P-value = 0.006 and region of arrival of the passengers x2 26.2, P-value = 0.000.

CONCLUSIONS

The study results revealed that most of the travelers arrived at Islamabad Airport had a low risk perception about communicable and vector borne diseases that may lead to increase in burden on health care system in Pakistan as well as export of any new disease from Pakistan to other parts of the world where it does not exist already.
Overview of Formulation of Triangulation Network Model Using Simulate Environment for Co-Operative Communication in WSN Using Matlab
Authors: Dighorikar Ganesh , Hedaoo Alankar , Katekhaye Kavi , Zode Khushali , Mahawadiwar Prof. Vivek. N.
Published: February 2022

Abstract: Wireless Sensor Networks (WSNs) gained universal attention now a day owing to This innovative is sensing technology to incorporate an immense number sensor nodes or motes set up in an area of perceive any continuously are fluctuating physical to phenomena. These tiny sensor nodes sense and process the sensed data and transfer this information to a base station or sink via radio frequency (RF) channel. The small size of these sensors is an advantage as it can be easily embedded within any device or in any environment. This feature has attracted the use of WSNs in immense applications especially in monitoring and tracking; the most prominent being the surveillance applications. But this type of tiny sizes of sensors to nodes restricts to resourcing capabilities. Usually to WSNs are install to application area to the human intervention of quite risk and difficult. The sense information might to need to taking the critical decisions to emergency applications. So maintaining the connectivity of the network is of utmost importance. The efficient use of the available resources to the maximum extend is a necessity to prolong the network lifetime. Most of research the area of WSNs has concentrate on energy efficiency where the design of energy efficient routing protocols plays a major role. The triangulations rules were applied for 20, 50 and 100 nodes demonstration for WSNs integrated with co-operative communications.
Applications of Artificial Neural Networks to Solve Ordinary Differential Equations
Authors: Sundaram Arunachalam
Published: February 2022

Abstract: Applications of Neural Networks to numerical problems have gained increasing interest. Solving Ordinary Differential Equations can be realized with simple artificial neural network architectures. In this paper, first step is training a Neural Network to satisfy the condition required by a differential equation and then finding a function whose derivative satisfies the Ordinary Differential Equation condition. The method of solving differential equation is implemented in Python Programming using the TensorFlow library. Keywords: Neural Network, Differential Equation, Loss function, Train function, Mean Squared Error, TensorFlow.
El valor agregado comunitario: una estrategia para impulsar el desarrollo económico local
Authors: Reyes Garcia Martin
Published: February 2022

El estado de Oaxaca es reconocido por albergar poblaciones con índices de pobreza y marginación que superan la media nacional, así como por la riqueza natural y cultural que posee su territorio. A pesar del potencial económico que tienen sus recursos naturales y culturales, aún no ha sido plenamente valorado provocando su desperdicio. Al respecto, se incorpora el término Valor Agregado Comunitario (VAC), cuyo objetivo es establecer una estrategia que permita aprovechar sustentablemente los recursos naturales o culturales de las poblaciones para obtener un beneficio económico y social que propicie el interés por valorarlos y preservarlos. En 2015 se llevó a cabo un estudio en la población de Rosario Nuevo que originó el término VAC y permitió establecer su metodología basada en detectar, evaluar e incorporar el potencial económico del los recursos naturales o culturales de las poblaciones mediante el desarrollo de alguna actividad productiva. Por tal motivo, en la población de estudio, se detectó y evaluó la disponibilidad del recurso agua que posteriormente se incorporó en la instalación de una granja acuícola que actualmente constituye una fuente de alimento e ingresos, así como una motivación para sus habitantes por valorar, cuidar y preservar su recurso.
SÍNDROME HEPATORRENAL: REVISIÓN DE LA LITERATURA
Authors: Sanabria Aguilar Diana Paola
Published: February 2022

El síndrome hepatorrenal es una disfunción renal que ocurre en pacientes con enfermedad hepática crónica como cirrosis hepática o enfermedad hepática aguda, caracterizada por la activación de mecanismos reguladores que conducen a disminución de la tasa de filtrado glomerular. Clínicamente el síndrome hepatorrenal se divide en dos tipos, el tipo 1 y el tipo 2. El tipo 1 se caracteriza por una pérdida rápida y progresiva de la función renal mientras que el tipo 2 se caracteriza por ser de progresión lenta y de mejor pronóstico. No existen hallazgos clínicos específicos, sin embargo, sus manifestaciones clínicas reflejan la enfermedad hepática avanzada subyacente, la insuficiencia renal y las anomalías circulatorias presentes. La opción terapéutica más adecuada es el trasplante hepático, pero no todos los pacientes pueden recibirlo, mientras se accede a dicho manejo una opción es el tratamiento medicamentoso con vasoconstrictores y albúmina.
A quantum prediction as a collection of epistemically restricted classical predictions
Authors: Braasch Jr. William F. , Wootters William K.
Published: February 2022

Spekkens has introduced an epistemically restricted classical theory of discrete systems, based on discrete phase space. The theory manifests a number of quantum-like properties but cannot fully imitate quantum theory because it is noncontextual. In this paper we show how, for a certain class of quantum systems, the quantum description of an experiment can be decomposed into classical descriptions that are epistemically restricted, though in a different sense than in Spekkens' work. For each aspect of the experiment—the preparation, the transformations, and the measurement—the epistemic restriction limits the form of the probability distribution an imagined classical observer may use. There are also global constraints that the whole collection of classical descriptions must satisfy. Each classical description generates its own prediction regarding the outcome of the experiment. One recovers the quantum prediction via a simple but highly nonclassical rule: the "nonrandom part" of the predicted quantum probabilities is obtained by summing the nonrandom parts of the classically predicted probabilities. By "nonrandom part" we mean the deviation from complete randomness, that is, from what one would expect upon measuring the fully mixed state.
SURVEI SARANA CABANG OLAHRAGA DI KOTA JAMBI
Authors: Rasian Rahmat
Published: February 2022

Olahraga merupakan suatu carauntuk menjaga agar kesegaran jasmani  agar tetap berada dalam  kondisi  yang  baik.  Dalam olahraga sarana dan prasarana yang memadai sangat berpengaruh dalam pembentukan atlet yang berprestasi. Media sarana dan prasarana dalam melakukan latihan merupakan suatu hal yang sangat vital. Untuk mengetahui kondisi mengenai sarana dan prasarana cabang olahraga di Kota Jambi penulis ingin melakukan penelitian dengan judul “Survei Sarana Cabang Olahraga Di Kota Jambi”.Penelitian ini bertujuan untuk mengetahui kondisi sarana cabang olahraga di Kota Jambi. Jenis penelitian ini adalah deskriptif kuantitatif . penelitian ini menggunakan metode survei dan teknik pengumpulan data menggunakan lembar observasi dan dokumentasi. Populasi dalam penelitian ini adalah cabang olahraga di Kota Jambi. Dan sampel menggunakan 5 cabang olahraga di Kota Jambi. Teknik analisis data yang digunakan dalam penelitian ini adalah statistik kuantitatif.Hasil penelitian menunjukan bahwasurvei sarana cabang olahraga Dayung di Kota Jambi yang berkategori sangat baik sebanyak 2 item sarana dengan persentase sebesar 13.33%, berkategori baik sebanyak 1 item sarana dengan persentase 6.67%, berkategori Cukup sebanyak 6item sarana dengan persentase 40% dan berkategori kurang sebanyak 6 item dengan persentase 40%. Cabang olahraga Gulat di Kota Jambi yang berkategori sangat baik sebanyak 2 item dengan persentase sebesar 40% dan berkategori cukup sebanyak 3 item dengan persentase 60%.

Kata Kunci: Survei, Sarana Cabang Olahraga
Evaluating and ranking decision making units in the two-stage network DEA based on reference frontier
Authors: abdali elham , Fallahnejad Reza
Published: February 2022

The present study proposes a method for evaluating and ranking the
efficiency of decision-making units (DMUs) that has a two-stage network
structure in data envelopment analysis (DEA). Measuring the efficiency
of two-stage network systems in data envelopment analysis has developed
considerably, but ranking it in a logical and accurate analysis is a
subject that still needs further study. In the present study, a model is
presented that can consider the impact of each efficient DMUs on the
whole two-stage network system, as well as using the reference frontier,
the impact of each efficient DMUs in each evaluating non-efficient DMUs.
It also provided more information to rank and identify the impact of
extreme efficient DMUs on non-efficient DMUs by reference frontier. The
concept of reference frontier introduced in the present study has the
potential to determine the contribution of each extreme efficient DMUs
in constructing a reference frontier for each non-extreme efficient DMUs
and non-efficient DMUs. These facts have been investigated using logical
reasoning and proof of several theorems, and have been discussed with a
Practical example.
A modified Lyapunov method and its applications to ODE
Authors: Gadella Manuel , Lara Luis Pedro
Published: February 2022

Here, we propose a method to obtain local analytic approximate solutions
of ordinary differential equations with variable coefficients, or even
some non-linear equations, inspired in the Lyapunov method, where
instead of polynomial approximations, we use truncated Fourier series
with variable coefficients as approximate solutions. In the case of
equations admitting periodic solutions, an averaging over the
coefficients gives global solutions. We show that, under some
restrictive condition, the method is equivalent to the
Picard-Lindel\”of method. After some numerical
experiments showing the efficiency of the method, we apply it to
equations of interest in Physics, in which we show that our method
possesses an excellent precision even with low iterations.
Deconvolution closure for mesoscopic continuum models of particle systems
Authors: Panchenko Alexander , Barannyk Lyudmyla , Cooper Kevin
Published: February 2022

We present a framework for derivation of closed-form continuum equations
governing mesoscale dynamics of large particle systems. Balance
equations for spatial averages such as density, linear momentum, and
energy were previously derived by a number of authors. These equations
are exact, but are not in closed form because the stress and the heat
flux (e.g. stress in the momentum balance equation) cannot be evaluated
without the knowledge of particle positions and velocities. Recently, we
proposed a method for approximating exact fluxes by true constitutive
equations, that is, using non-local operators acting only on the average
density and velocity. In the paper, constitute operators are obtained by
using filtered regularization methods from the theory of ill-posed
problems. We also formulate conditions on fluctuation statistics which
permit approximating these operators by local equations. The performance
of the method is tested numerically using Fermi-Pasta-Ulam particle
chains with two different potentials: the classical Lennard-Jones, and
the purely repulsive potential used in granular materials modeling. The
initial conditions incorporate velocity fluctuations on scales that are
smaller than the size of the averaging window. Simulation results show
good agreement between the exact stress and its closed form
approximation.
Adoption of e-portfolios for Registered Nurses & Midwives Professional Registration and Revalidation in Ireland
Authors: Harrington Tracey , O'Neill Sandra
Published: February 2022

In many countries, such as Australia, Canada, the United Kingdom (UK), and the United States of America, Nursing and Midwifery Professional Bodies undergo a revalidation process demonstrating evidence of continuing professional development (CPD) and clinical practice hours in order to remain an active member on the professional register. In most countries this process involves documenting evidence in paper format. However, in the UK, our closest neighbour, eportfolio submission is now offered as an option for revalidation. Ireland is imminently moving towards introducing documented evidence as a requirement for continued registration as currently, there are no requirements to demonstrate evidence of continuing professional development or clinical practice as part of the annual re-registration process. While there are plans to address this in the near future, there are no details regarding the revalidation requirements or process. Irish undergraduate and postgraduate nursing and midwifery students are beginning to use eportfolios for assessment purposes and are increasingly familiar with the online eportfolio platforms. In this paper, we provide a rationale for the Irish Nursing and Midwifery Board (NMBI) to adopt eportfolios for the submission of documentary evidence for both initial registration and revalidation. We will examine the advantages and the barriers to the introduction of eportfolios in this context. The use of eportfolios would provide the NMBI an opportunity to lead the way in registration and revalidation processes internationally, enabling nurses and midwives in Ireland to embrace the opportunities that the digital age presents.
Participant Engagement with Eportfolio on the PACT Digital Badge: An Explanatory Sequential Mixed-Methods Analysis
Authors: O Neill Marie , McCarthy Ken
Published: February 2022

This paper explores participants’ perceptions of eportfolio on the National Forum for the Enhancement of Teaching and Learning’s PACT digital badge in which eportfolio is a central component of the teaching and learning experience. The PACT badge was launched in 2018 by the National Forum to promote engagement with their National Professional Development Framework for All Those Who Teach in Higher Education (National Forum, 2016). A small but growing body of studies indicates that the pairing of eportfolio with digital badges increases participant engagement with course content, facilitates the open evidencing of skill acquisition as well the transfer of knowledge beyond the life span of the course (Kehoe and Goudzwaard, 2015; Ambrose and Anthony 2016; Nilson and Dewiyanti, 2019). In January 2021, an explanatory, sequential mixed methods approach comprising a survey and focus group was employed to obtain and analyse feedback from graduates of three iterations of the PACT digital badge in relation to their perceptions of the eportfolio component. Data indicated a range of benefits including enhanced digital literacy, an enhanced ability to reflect, a more engaging learning experience, more robust evidencing of professional development and increased engagement with the National Professional Development Framework for all Those Who Teach in Higher Education. Seventy-Eight percent of respondents stated that eportfolio was an important part of the PACT course. A key recommendation of the study is the additional front loading of support materials in relation to eportfolio engagement in Week 0 of the course in response to feedback in which PACT participants indicated that eportfolio could be technically challenging and time consuming. The findings of this exploratory study could be tested at larger scale across a wider range of National Forum digital badges that incorporate eportfolio.
Looping Everyone into the Conversation
Authors: Lyons Roisin , Lynch Ciara , McConalogue Eoghan
Published: February 2022

At its most fundamental, entrepreneurship involves discovering, evaluating, and exploiting opportunities to create future goods and services (Shane and Venkataraman, 2000). Acknowledging that characteristics, emotions, cognitive biases, and past experiences influence entrepreneurial activity and decision making (Shepherd and Patzelt, 2017; De Winnaar and Scholtz, 2019), many propose that active reflection is an important facet of the entrepreneurial curricula (Nabi et al., 2016; Santos et al., 2016). For the entrepreneurial student, learning to make rationale decisions is paramount, and this is vitally linked to their ability to reflect and be self-aware.

This study recounts the use of the eportfolio within a new large class (over 600 students) module in enterprise education. The module utilised an eportfolio reflective assignment to allow students express their feelings and knowledge about a series of attended entrepreneurial events and guest speaker seminars. In this paper, we present a novel insight into the efficacy of this curricular approach. External stakeholders who acted as mentors and speakers were asked to review a number of these student portfolios, and provide their thoughts on the assignments themselves, and the e-portfolio construct more generally. As such, this study highlights the multiple feedback loops of reflection which can be obtained from the eportfolio when used as a carefully considered pedagogical tool. It also highlights the integral role that industry stakeholders play in the enterprise curriculum.
Eportfolio in Ireland: A landscape snapshot of current practice
Authors: Farrell Orna , Buckley Karen , Donaldson Lisa , Farrelly Tom
Published: February 2022

This article reports on a study that explored eportfolio practice in Irish higher education. The aim of this research was to gain a landscape snapshot of eportfolio practice and technologies across Irish Higher Education Institutes (HEI) and to address a gap in the literature that there is little empirical evidence about how Irish HEIs engage and adopt eportfolio in practice. The project adopted a mixed method approach and was framed by two research questions: RQ1: What are the features of eportfolio practice in Irish higher education? RQ2: What are the experiences of Irish higher education practitioners in adopting eportfolio? Data was collected from seventy-nine participants from a range of Irish HEIs using an anonymous online survey. The four central themes that make up the study’s findings highlight key issues related to institutional engagement with eportfolio including features of eportfolio practice; technology underpinning eportfolio practice; enablers of eportfolio adoption and barriers to eportfolio adoption. The findings of this study indicate that Irish teaching staff use eportfolios with their students primarily for assessment, reflection, to support placement experiences and to develop student employability skills. There was also evidence that staff are using eportfolios for personal and/or professional purposes. Furthermore, it is particularly noteworthy that hardly anyone in the study reported evaluating their eportfolio practice. In addition, our findings indicate that the implementation and adoption of eportfolio by Irish HEIs has been quite uneven, the majority of institutions were reported to be at the early stages of adoption. While this study provides useful insight regarding the institutional and staff perspective, the research team do acknowledge that the student voice was not captured in this instance.