bluuebunny/crossref_metadata_2025 huggingface dataset:
Recombinant Human Perlecan DV and Its LG3 Subdomain Are Neuroprotective and Acutely Functionally Restorative in Severe Experimental Ischemic Stroke
Authors: Biose Ifechukwude Joachim , Rutkai Ibolya , Clossen Bryan , Gage Gary , Schechtman Kenneth , Adkisson H. Davis , Bix Gregory J.
Published: December 2022

Despite recent therapeutic advancements, ischemic stroke remains a major cause of death and disability. It has been previously demonstrated that  ~ 85-kDa recombinant human perlecan domain V (rhPDV) binds to upregulated integrin receptors (α2β1 and α5β1) associated with neuroprotective and functional improvements in various animal models of acute ischemic stroke. Recombinant human perlecan laminin-like globular domain 3 (rhPDVLG3), a 21-kDa C-terminal subdomain of rhPDV, has been demonstrated to more avidly bind to the α2β1 integrin receptor than its parent molecule and consequently was postulated to evoke significant neuroprotective and functional effects. To test this hypothesis, fifty male C57Bl/6 J mice studied in a t-MCAO model were randomly allocated to either rhPDV treatment, rhPDVLG3, or equivalent volume of PBS at the time of reperfusion in a study where all procedures and analyses were conducted blind to treatment. On post-MCAO day 7, 2,3,5-triphenyltetrazolium chloride staining of brain slices was used to quantify infarct volume. We observed that treatment with rhPDVLG3 reduced infarct volume by 65.6% (p = 0.0001), improved weight loss (p < 0.05), and improved functional outcome measures (p < 0.05) when compared to PBS controls, improvements which were generally greater in magnitude than those observed for 2 mg/kg of rhPDV. In addition, treatment with 6 mg/kg of rhPDVLG3 was observed to significantly reduce mortality due to stroke in one model, an outcome not previously observed for rhPDV. Our initial findings suggest that treatment with rhPDVLG3 provides significant improvement in neuroprotective and functional outcomes in experimental stroke models and that further investigation of rhPDVLG3 as a novel neuroprotective therapy for patients with stroke is warranted.
Biases in COVID-19 Case and Death Definitions: Potential Causes and Consequences
Authors: Brown Ronald B.
Published: December 2022

This paper investigates three controversies involving potential causes and consequences of information bias in case and death definitions during the coronavirus disease (COVID-19) pandemic. First, evidence suggests China’s surveillance data were biased and misinterpreted by the World Health Organization (WHO), prompting the WHO to advise nations to copy China’s lockdowns. China appeared to use narrow diagnostic definitions that undercounted cases and deaths. Second, novel genomic data disseminated during the pandemic without adequate guidance from rigorous epidemiologic studies biased infection control policies in many countries. A novel genomic sequence of a virus is insufficient to declare new cases of a novel disease. Third, media reports of COVID-19 surveillance data in many nations appeared to be biased. Broadened surveillance definitions captured additional information, but unadjusted surveillance data disseminated to the public are not true cases and deaths. Recommendations include clarification of the proper use of diagnostic and surveillance case and death definitions to avoid information bias.
COVID-19 Vaccination in a Former Fukushima Nuclear Accident Evacuation Area: COVID-19 Vaccination for Former Evacuees
Authors: Ito Naomi , Yoshida Sachiko , Sato Mika , Yasui Kiyotaka , Sonoda Yuki , Tsubokura Masaharu
Published: December 2022

After the Fukushima accident in 2011, approximately 160000 residents were forced to evacuate the site. The evacuation order has since been lifted and the Japanese government is now advancing a return strategy. As the return proceeds, deterioration of health indicators and measures in the municipalities around the nuclear power plant remains unchanged. This affected the local governments’ coronavirus disease (COVID-19) vaccination drive during the COVID-19 pandemic. In Japan, municipalities keep track of residents’ information and implement health-related measures. However, many residents evacuated the town, thus leaving their registered residence. With long-term evacuation and few returnees, it was difficult for government officials to constantly monitor the residents’ health. Therefore, there is an urgent need to maintain residents’ records and ensure that they receive health services without any gap. This report aimed to provide implications for post-disaster community health services and support as observed during the COVID-19 vaccination program at a disaster site.
Contested Caryatids: Architecture, Modernity, and Race around 1900
Authors: Jütte Daniel
Published: December 2022

In the nineteenth century, caryatids saw an unprecedented renaissance in European architecture. This article explores the cultural history of these female column-statues in nineteenth- and early-twentieth-century Europe. The focus is on central Europe, and three cities—Berlin, Frankfurt am Main, and Vienna—play a particularly important role in this exploration. Through a reading of historical, visual, and literary sources, the article probes how these statues came to embody, on both a material and a metaphorical level, the social aspirations and societal rifts that marked the bourgeois age. The nexus, real and imagined, between caryatids and Jews is particularly illustrative here. In tracing antagonistic and largely forgotten discourses, the article seeks to shed light on a larger subject that is still underexplored: the complex entanglement of architecture, religion, and race in the long nineteenth century.
The Second Nutrition and Cancer Networking Meeting Nutrition and Breast Cancer: Translating Evidence into Practice
Authors: Thorne James L , Holen Ingunn , Corfe Bernard M
Published: December 2022

The 2nd Nutrition and Cancer Networking Meeting ‘Nutrition and Breast Cancer: Translating Evidence into Practice’ was held at Newcastle University in May 2022, with support from the Nutrition Society and British Association for Cancer Research. The first meeting in this series was held in Sheffield in 2019. The aim of this joint meeting was to bring together researchers with an interest in nutrition and breast cancer, with the programme spanning topics from risk and prevention to nutrition during treatment and beyond. Several key themes emerged, including the importance of engaging patients in the development of interventions and trials, making trials more accessible to diverse communities; training of clinical staff in nutrition and latest evidence; wider range of compounds should be considered in food composition tables; and alternative trial designs can be considered for prevention research to reduce financial burden and increase power.
Adaptive lead-through teaching control for spray-painting robot with closed control system
Authors: Liu Yajun , Zi Bin , Wang Zhengyu , Qian Sen , Zheng Lei , Jiang Lijun
Published: December 2022

Industrial robots are widely used in the painting industry, such as automobile manufacturing and solid wood furniture industry. An important problem is how to improve the efficiency of robot programming, especially in the current furniture industry with multiple products, small batches and increasingly high demand for customization. In this work, we propose an outer loop adaptive control scheme, which allow users to realize the practical application of the zero-moment lead-through teaching method based on dynamic model without opening the inner torque control interface of robots. In order to accurately estimate the influence of joint friction, a friction model is established based on static, Coulomb and viscous friction characteristics, and the Sigmoid function is used to represent the transition between motion states. An identification method is used to quickly identify the dynamic parameters of the robot. The joint position/speed command of the robot’s inner joint servo loop is dynamically generated based on the user-designed adaptive control law. In addition, the zero-moment lead-through teaching scheme based on the dynamic model is applied to a spray-painting robot with closed control system. In order to verify our method, CMA GR630ST is used to conduct experiments. We identified the parameters of the dynamic model and carried out the zero-moment lead-through teaching experiment to track the target trajectory. The results show that the proposed method can realize the application of modern control methods in industrial robot with closed control systems, and achieve a preliminary exploration to improve the application scenarios of spray-painting robots.
Investigating sensitivity through the lens of parents: validation of the parent-report version of the Highly Sensitive Child scale
Authors: Sperati Alessandra , Spinelli Maria , Fasolo Mirco , Pastore Massimiliano , Pluess Michael , Lionetti Francesca
Published: December 2022

Children differ in their environmental sensitivity (ES), which can be measured observationally or by self-report questionnaire. A parent-report scale represents an important tool for investigating ES in younger children but has to be psychometrically robust and valid. In the current multistudy, we validated the parent-report version of the Highly Sensitive Child (HSC-PR) scale in Italian children, evaluating its factorial structure (Study 1, N = 1,857, 6.2 years, age range: 2.6–14 years) through a multigroup Confirmatory Factory Analysis in preschoolers (n = 1,066, 4.2 years) and school-age children (n = 791, 8.8 years). We then investigated the HSC-PR relationship with established temperament traits (Study 2, N = 327, 4.3 years), before exploring whether the scale moderates the effects of parenting stress on children’s emotion regulation (Study 3, N = 112, 6.5 years). We found support for a bi-factor structure in both groups, though in preschoolers minor adaptations were suggested for one item. Importantly, the HSC-PR did not fully overlap with common temperament traits and moderated the effects of parenting stress on children emotion regulation. To conclude, the HSC-PR performs well and appears to capture ES in children.
ON THE ALGEBRAS AND OF AN ULTRASPHERICAL HYPERGROUP
Authors: ESMAILVANDI REZA , NEMATI MEHDI , KUMAR NAGESWARAN SHRAVAN
Published: December 2022

Let H be an ultraspherical hypergroup and let
$A(H)$
be the Fourier algebra associated with
$H.$
In this paper, we study the dual and the double dual of
$A(H).$
We prove among other things that the subspace of all uniformly continuous functionals on
$A(H)$
forms a
$C^*$
-algebra. We also prove that the double dual
$A(H)^{\ast \ast }$
is neither commutative nor semisimple with respect to the Arens product, unless the underlying hypergroup H is finite. Finally, we study the unit elements of
$A(H)^{\ast \ast }.$
Potential Prevalence, Pattern, and Risk Factors of Insomnia Symptoms in Adolescent Elite Athletes
Authors: Gerber Markus , Kellmann Michael , Lang Christin , Brand Serge , Gygax Basil , Ludyga Sebastian , Müller Caspar , Ramseyer Sven , Jakowski Sarah
Published: December 2022

Abstract. Sleep disorders are an important issue among elite athletes. In this study, we used data from two studies to examine the prevalence, pattern, and risk factors of insomnia symptoms among adolescent elite athletes. We assessed insomnia symptoms using the Insomnia Severity Index. The prevalence of moderate-to-severe insomnia varied between 5 – 11 %, with 36 – 54 % of the athletes reporting subthreshold insomnia and 61 – 73 % perceiving at least one insomnia symptom. Female participants were more prone to report insomnia symptoms. Dysfunctional sleep-related cognitions were the most critical risk factor. We identified three groups with distinct insomnia symptom patterns via latent class analyses: 43 % of the participants were characterized as healthy sleepers, 45 % reported medium sleep without heightened concerned about sleep problems, and 12 % reported poor sleep and were substantially worried/distressed about their impaired sleep. More information is needed on how dysfunctional sleep-related cognitions can be influenced to improve athletes’ sleep and to foster their well-being.
Sleep Quality and Well-Being in Junior Elite Athletes
Authors: Zepp Christian , Ohlert Jeannine , Kleinert Jens
Published: December 2022

Abstract. Little cross-sectional and even less longitudinal research has been conducted on sleep quality and well-being in junior elite athletes. This study analyzed the relationship between subjective sleep quality and both psychological and physiological well-being in junior elite athletes using both a cross-sectional ( N = 625 athletes; 49.9 % = female; M = 16.4 years, SD = 3.5 years) and a longitudinal approach ( n = 79; 44.3 % = female; M = 16.4 years, SD = 3.5 years) over a period of M = 1.66 years ( SD = 0.87 years). The results demonstrated that both samples showed that subjective sleep quality is correlated with well-being in junior elite athletes. In addition, the results showed that athletes of prepuberty age reported significantly better sleep quality than athletes during and after puberty, and that the relationship between sleep quality and psychological well-being is stronger in female junior athletes than in male athletes. This study emphasizes the need to ensure quality sleep in junior elite athletes.
The Dark Triad of Personality in Personnel Selection
Authors: Schwarzinger Dominik
Published: December 2022

How to use the dark triad in personnel selection

Presents the latest research and theories
Highlights the gains and risks of these traits
Provides concrete recommendations for use in selection processes
Summarizes legal and professional guidelines

More about the book

This book explores the theoretical basis and state of the art of research on narcissism, Machiavellianism, and subclinical psychopathy. It also answers complex questions on the structure of the dark triad and its measurement for practical applications. Learn about how people high in these characteristics can, on the one hand, experience individual career success and high work performance and, on other hand, present risks in the workplace with abusive and destructive leadership and counterproductive behavior. In addition, the author summarizes the legal and professional guidelines when assessing the dark personality characteristics of job applicants, examines the acceptance and social validity of such assessments, evaluates the available instruments, and makes recommendations for practical applications and further research.

With the focus on practical applications, the book presents the development, quality, and application of a test designed for use in organizations to capture the dark triad in the workplace. Concrete recommendations are given on how to use the characteristics narcissism, Machiavellianism, and subclinical psychopathy in personnel selection.

Researchers and practitioners interested in applying the dark triad in personnel work will find this book full of valuable information on how to undertake legally compliant processes and how to utilize the great potential these personality characteristics have in making decisions on aptitude.
A Modeling Perspective on the Lingering Glacial Sea Surface Temperature Conundrum
Authors: Krätschmer S. , Cauquoin A. , Lohmann G. , Werner M.
Published: December 2022

The strong cooling during the Last Glacial Maximum (LGM, 21 ka BP) provides a rigorous test of climate models' ability to simulate past and future climate changes. We force an atmospheric general circulation model with two recent global LGM sea surface temperature (SST) reconstructions, one suggesting a weak and the other a more pronounced cooling, and compare the simulated land surface temperatures (LSTs) to reconstructed data. Our results do not confirm either SST reconstruction. The cold SST data set leads to good agreement between simulated and observed LSTs at low latitudes, but is systematically too cold at mid‐latitudes. The opposite is true for the warm SST data set. Differences between the simulated LSTs are caused by varying land surface albedos, which is lower for the warmer SST reconstruction. The inconsistency between reconstructed and simulated climate points to a potentially significant bias in the proxy reconstructions and/or the climate sensitivity of current climate models.
Satellite‐Borne Observations of Ozone Impact by the November 2001 Solar Proton Event
Authors: Nilsen K. , Kero A. , Verronen P. T. , Szeląg M. E.
Published: December 2022

The November 2001 Solar Proton Event (SPE) is one of the strongest events in the era of satellite observations. However, no observational case study of this exceptional event's impact on atmospheric chemistry has been reported. In this paper, we use satellite‐based observations from Optical Spectrograph and Infrared Imaging Systems (OSIRIS) to quantify the SPE impact on middle atmospheric O3 in the southern hemisphere during summertime conditions. The results show a relatively modest, yet detectable, O3 depletion in the upper stratosphere and lower mesosphere. Compared to the observations, the Whole Atmosphere Community Climate Model (WACCM‐D) simulates somewhat lower O3 levels before the event but captures well the relative ozone depletion. The largest depletion is seen on November 6th, after the Geostationary Operational Environment Satellite observed the peak proton fluxes. On this day, the O3 depletion was observed and simulated from the pole to 55°S geographic latitude. The daily polar cap (poleward of 60°S geographic latitude) averaged O3 profiles show a maximum depletion of 16.6 ± 2.2% at 1 hPa and 18.8 ± 3.3% at 1.5 hPa altitude, by OSIRIS and WACCM‐D, respectively. After the SPE, an enhancement in NOx is simulated by the results of the model within altitudes of the observation, which is well correlated with the observed and modeled O3 depletion. Challenges related to the detection of SPE impact on O3 in the summer hemisphere are discussed. We find that a careful analysis of simulation results can be essential when isolating the SPE impact from background variation.
Expectations, concerns, and attitudes regarding whole-genome sequencing studies: a survey of cancer patients, families, and the public in Japan
Authors: Ri Izen , Kawata Junichi , Nagai Akiko , Muto Kaori
Published: December 2022

Whole-genome sequencing (WGS) is being used in research and clinical settings in cancer genomics. Studies show that cancer patients generally have positive attitudes toward tumor profiling tests; however, few works revealed their attitudes toward WGS. This study clarifies the expectations, concerns, and result preferences of cancer patients (CPs), family members (FMs) and general adults (GAs) regarding WGS study in Japan. We conducted an anonymous survey with 1204 CPs, 5958 FMs, and 2915 GAs in 2021. Despite low awareness of the WGS studies, CPs had the highest expectations for it. FMs had a higher level of concern than CPs and GAs; feeling anxious by knowing the results, being treated unfavorably if germline findings were detected. Both the FMs and CPs were highly concerned about the protection of genetic information. CPs preferred results with actionability, however, only half preferred to know germline findings. Given the possibility of detecting variants across multidisciplinary diseases and the long-term continuity of WGS research, a system is needed in which study participants can consult and receive decision-making support at any time according to their needs.
Silicone engineered anisotropic lithography for ultrahigh-density OLEDs
Authors: Kweon Hyukmin , Choi Keun-Yeong , Park Han Wool , Lee Ryungyu , Jeong Ukjin , Kim Min Jung , Hong Hyunmin , Ha Borina , Lee Sein , Kwon Jang-Yeon , Chung Kwun-Bum , Kang Moon Sung , Lee Hojin , Kim Do Hwan
Published: December 2022

Ultrahigh-resolution patterning with high-throughput and high-fidelity is highly in demand for expanding the potential of organic light-emitting diodes (OLEDs) from mobile and TV displays into near-to-eye microdisplays. However, current patterning techniques so far suffer from low resolution, consecutive pattern for RGB pixelation, low pattern fidelity, and throughput issue. Here, we present a silicone engineered anisotropic lithography of the organic light-emitting semiconductor (OLES) that in-situ forms a non-volatile etch-blocking layer during reactive ion etching. This unique feature not only slows the etch rate but also enhances the anisotropy of etch direction, leading to gain delicate control in forming ultrahigh-density multicolor OLES patterns (up to 4500 pixels per inch) through photolithography. This patterning strategy inspired by silicon etching chemistry is expected to provide new insights into ultrahigh-density OLED microdisplays.
Sex differences in allometry for phenotypic traits in mice indicate that females are not scaled males
Authors: Wilson Laura A. B. , Zajitschek Susanne R. K. , Lagisz Malgorzata , Mason Jeremy , Haselimashhadi Hamed , Nakagawa Shinichi
Published: December 2022

Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research targeted at improving treatment, increasing health span, and reducing the financial burden of health care, has mostly been conducted on male animals and cells. The extent to which sex differences in phenotypic traits are explained by sex differences in body weight remains unclear. We quantify sex differences in the allometric relationship between trait value and body weight for 363 phenotypic traits in male and female mice, recorded in >2 million measurements from the International Mouse Phenotyping Consortium. We find sex differences in allometric parameters (slope, intercept, residual SD) are common (73% traits). Body weight differences do not explain all sex differences in trait values but scaling by weight may be useful for some traits. Our results show sex differences in phenotypic traits are trait-specific, promoting case-specific approaches to drug dosage scaled by body weight in mice.
Molecular models of multiple sclerosis severity identify heterogeneity of pathogenic mechanisms
Authors: Kosa Peter , Barbour Christopher , Varosanec Mihael , Wichman Alison , Sandford Mary , Greenwood Mark , Bielekova Bibiana
Published: December 2022

While autopsy studies identify many abnormalities in the central nervous system (CNS) of subjects dying with neurological diseases, without their quantification in living subjects across the lifespan, pathogenic processes cannot be differentiated from epiphenomena. Using machine learning (ML), we searched for likely pathogenic mechanisms of multiple sclerosis (MS). We aggregated cerebrospinal fluid (CSF) biomarkers from 1305 proteins, measured blindly in the training dataset of untreated MS patients (N = 129), into models that predict past and future speed of disability accumulation across all MS phenotypes. Healthy volunteers (N = 24) data differentiated natural aging and sex effects from MS-related mechanisms. Resulting models, validated (Rho 0.40-0.51, p < 0.0001) in an independent longitudinal cohort (N = 98), uncovered intra-individual molecular heterogeneity. While candidate pathogenic processes must be validated in successful clinical trials, measuring them in living people will enable screening drugs for desired pharmacodynamic effects. This will facilitate drug development making, it hopefully more efficient and successful.
PRDM1/BLIMP1 induces cancer immune evasion by modulating the USP22-SPI1-PD-L1 axis in hepatocellular carcinoma cells
Authors: Li Qing , Zhang Liren , You Wenhua , Xu Jiali , Dai Jingjing , Hua Dongxu , Zhang Ruizhi , Yao Feifan , Zhou Suiqing , Huang Wei , Dai Yongjiu , Zhang Yu , Baheti Tasiken , Qian Xiaofeng , Pu Liyong , Xu Jing , Xia Yongxiang , Zhang Chuanyong , Tang Jinhai , Wang Xuehao
Published: December 2022

Programmed death receptor-1 (PD-1) blockade have achieved some efficacy but only in a fraction of patients with hepatocellular carcinoma (HCC). Programmed cell death 1 ligand 1 (PD-L1) binds to its receptor PD1 on T cells to dampen antigen-tumor immune responses. However, the mechanisms underlying PD-L1 regulation are not fully elucidated. Herein, we identify that tumoral Prdm1 overexpression inhibits cell growth in immune-deficient mouse models. Further, tumoral Prdm1 overexpression upregulates PD-L1 levels, dampening anti-tumor immunity in vivo, and neutralizes the anti-tumor efficacy of Prdm1 overexpression in immune-competent mouse models. Mechanistically, PRDM1 enhances USP22 transcription, thus reducing SPI1 protein degradation through deubiquitination, which enhances PD-L1 transcription. Functionally, PD-1 mAb treatment reinforces the efficacy of Prdm1-overexpressing HCC immune-competent mouse models. Collectively, we demonstrate that the PRDM1-USP22-SPI1 axis regulates PD-L1 levels, resulting in infiltrated CD8+ T cell exhaustion. Furthermore, PRDM1 overexpression combined with PD-(L)1 mAb treatment provides a therapeutic strategy for HCC treatment.
The dominant nature of Herzberg–Teller terms in the photophysical description of naphthalene compared to anthracene and tetracene
Authors: Manian Anjay , Russo Salvy P.
Published: December 2022

The first order and second order corrected photoluminescence quantum yields are computed and compared to experiment for naphthalene in this manuscript discussing negative results. Results for anthracene and tetracene are recalled from previous work (Manian et al. in J Chem Phys 155:054108, 2021), and the results for all three polyacenes are juxtaposed to each other. While at the Franck–Condon point, each of the three noted polyacenes were found to possess a quantum yield near unity. Following the consideration of Herzberg–Teller effects, quantum yields stabilised for anthracene and tetracene to 0.19 and 0.08, respectively. Conversely, the second order corrected quantum yield for naphthalene was found to be 0.91. Analysis of this result showed that while the predicted non-radiative pathways correlate well with what should be expected, the approximation used to calculate second order corrected fluorescence, which yielded very positive results for many other molecular systems, here is unable to account for strong second order contributions, resulting in a grossly overestimated rate of fluorescence. However, substitution of an experimental radiative rate results in a quantum yield of 0.33. This work extols the importance of Herzberg–Teller terms in photophysical descriptions of chromophores, and highlights those cases in which a treatment beyond the above approximation is required.
Automated analysis of fibrous cap in intravascular optical coherence tomography images of coronary arteries
Authors: Lee Juhwan , Pereira Gabriel T. R. , Gharaibeh Yazan , Kolluru Chaitanya , Zimin Vladislav N. , Dallan Luis A. P. , Kim Justin N. , Hoori Ammar , Al-Kindi Sadeer G. , Guagliumi Giulio , Bezerra Hiram G. , Wilson David L.
Published: December 2022

Thin-cap fibroatheroma (TCFA) and plaque rupture have been recognized as the most frequent risk factor for thrombosis and acute coronary syndrome. Intravascular optical coherence tomography (IVOCT) can identify TCFA and assess cap thickness, which provides an opportunity to assess plaque vulnerability. We developed an automated method that can detect lipidous plaque and assess fibrous cap thickness in IVOCT images. This study analyzed a total of 4360 IVOCT image frames of 77 lesions among 41 patients. Expert cardiologists manually labeled lipidous plaque based on established criteria. To improve segmentation performance, preprocessing included lumen segmentation, pixel-shifting, and noise filtering on the raw polar (r, θ) IVOCT images. We used the DeepLab-v3 plus deep learning model to classify lipidous plaque pixels. After lipid detection, we automatically detected the outer border of the fibrous cap using a special dynamic programming algorithm and assessed the cap thickness. Our method provided excellent discriminability of lipid plaque with a sensitivity of 85.8% and A-line Dice coefficient of 0.837. By comparing lipid angle measurements between two analysts following editing of our automated software, we found good agreement by Bland–Altman analysis (difference 6.7° ± 17°; mean ~ 196°). Our method accurately detected the fibrous cap from the detected lipid plaque. Automated analysis required a significant modification for only 5.5% frames. Furthermore, our method showed a good agreement of fibrous cap thickness between two analysts with Bland–Altman analysis (4.2 ± 14.6 µm; mean ~ 175 µm), indicating little bias between users and good reproducibility of the measurement. We developed a fully automated method for fibrous cap quantification in IVOCT images, resulting in good agreement with determinations by analysts. The method has great potential to enable highly automated, repeatable, and comprehensive evaluations of TCFAs.
Predictive modelling of Parkinson’s disease progression based on RNA-Sequence with densely connected deep recurrent neural networks
Authors: Ahmed Siraj , Komeili Majid , Park Jeongwon
Published: December 2022

The advent of recent high throughput sequencing technologies resulted in unexplored big data of genomics and transcriptomics that might help to answer various research questions in Parkinson’s disease (PD) progression. While the literature has revealed various predictive models that use longitudinal clinical data for disease progression, there is no predictive model based on RNA-Sequence data of PD patients. This study investigates how to predict the PD Progression for a patient’s next medical visit by capturing longitudinal temporal patterns in the RNA-Seq data. Data provided by Parkinson Progression Marker Initiative (PPMI) includes 423 PD patients without revealing any race, sex, or age information with a variable number of visits and 34,682 predictor variables for 4 years. We propose a predictive model based on deep Recurrent Neural Network (RNN) with the addition of dense connections and batch normalization into RNN layers. The results show that the proposed architecture can predict PD progression from high dimensional RNA-seq data with a Root Mean Square Error (RMSE) of 6.0 and a rank-order correlation of (r = 0.83,p < 0.0001) between the predicted and actual disease status of PD.
Ceramic-reinforced HEA matrix composites exhibiting an excellent combination of mechanical properties
Authors: Mehmood M. Adil , Shehzad Khurram , Mujahid M. , Yaqub Talha Bin , Godfrey Andy , Fernandes Filipe , Muhammad F. Z. , Yaqoob Khurram
Published: December 2022

CoCrFeNi is a well-studied face centered cubic (fcc) high entropy alloy (HEA) that exhibits excellent ductility but only limited strength. The present study focusses on improving the strength-ductility balance of this HEA by addition of varying amounts of SiC using an arc melting route. Chromium present in the base HEA is found to result in decomposition of SiC during melting. Consequently, interaction of free carbon with chromium results in the in-situ formation of chromium carbide, while free silicon remains in solution in the base HEA and/or interacts with the constituent elements of the base HEA to form silicides. The changes in microstructural phases with increasing amount of SiC are found to follow the sequence: fcc → fcc + eutectic → fcc + chromium carbide platelets → fcc + chromium carbide platelets + silicides → fcc + chromium carbide platelets + silicides + graphite globules/flakes. In comparison to both conventional and high entropy alloys, the resulting composites were found to exhibit a very wide range of mechanical properties (yield strength from 277 MPa with more than 60% elongation to 2522 MPa with 6% elongation). Some of the developed high entropy composites showed an outstanding combination of mechanical properties (yield strength 1200 MPa with 37% elongation) and occupied previously unattainable regions in a yield strength versus elongation map. In addition to their significant elongation, the hardness and yield strength of the HEA composites are found to lie in the same range as those of bulk metallic glasses. It is therefore believed that development of high entropy composites can help in obtaining outstanding combinations of mechanical properties for advanced structural applications.
Prospective multicentre study of host response signatures in neonatal sepsis in Sub Saharan Africa
Authors: Ezinmegnon Sem , Mommert Marine , Bartolo Francois , Agbota Gino , Darius Sossou , Briand Valérie , d’Almeida Marceline , Alao Maroufou Jules , Dossou-Dagba Ida , Massougbodji Achille , Lausten-Thomsen Ulrik , Pachot Alexandre , Vachot Laurence , Yugueros-Marcos Javier , Brengel-Pesce Karen , Fievet Nadine , Tissieres Pierre
Published: December 2022

Few biomarkers for sepsis diagnosis are commonly used in neonatal sepsis. While the role of host response is increasingly recognized in sepsis pathogenesis and prognosis, there is a need for evaluating new biomarkers targeting host response in regions where sepsis burden is high and medico-economic resources are scarce. The objective of the study is to evaluate diagnostic and prognostic accuracy of biomarkers of neonatal sepsis in Sub Saharan Africa. This prospective multicentre study included newborn infants delivered in the Abomey-Calavi region in South Benin and their follow-up from birth to 3 months of age. Accuracy of transcriptional (CD74, CX3CR1), proteic (PCT, IL-6, IL-10, IP-10) biomarkers and clinical characteristics to diagnose and prognose neonatal sepsis were measured. At delivery, cord blood from all consecutive newborns were sampled and analysed, and infants were followed for a 12 weeks’ period. Five hundred and eighty-one newborns were enrolled. One hundred and seventy-two newborns developed neonatal sepsis (29.6%) and death occurred in forty-nine infants (8.4%). Although PCT, IL-6 and IP-10 levels were independently associated with sepsis diagnosis, diagnostic accuracy of clinical variables combinations was similar to combinations with biomarkers and superior to biomarkers alone. Nonetheless, CD74, being the only biomarkers independently associated with mortality, showed elevated prognosis accuracy (AUC > 0.9) either alone or in combination with other biomarkers (eg. CD74/IP-10) or clinical criterion (eg. Apgar 1, birth weight). These results suggest that cord blood PCT had a low accuracy for diagnosing early onset neonatal sepsis in Sub Saharan African neonates, while association of clinical criterion showed to be more accurate than any biomarkers taken independently. At birth, CD74, either associated with IP-10 or clinical criterion, had the best accuracy in prognosing sepsis mortality.

Trial registration Clinicaltrial.gov registration number: NCT03780712. Registered 19 December 2018. Retrospectively registered.
Vitamin D metabolites and analytical challenges
Authors: Naik Megha , Kamath U Saritha , Uppangala Shubhashree , Adiga Satish Kumar , Patil Ajeetkumar
Published: December 2022

Vitamin D metabolites play a vital role in the human body. Current challenges of the existing methods and development with their merits and limitations in the assessment of vitamin D metabolites are described in this review.
A multicomponent gas wavelength selection method based on an absorbance mathematical model
Authors: Li Honglian , Yan Xiangyu , Yao Yuhang , Liang Yujiao , Li Wenduo , Fang Lide
Published: December 2022

In order to quickly and accurately determine the optimal absorption spectra of the gases to be measured, a method for selecting the optimal wavelengths for multicomponent gases was proposed.
In situ synthesis of CdS@NH2-MIL-125 nanocomposite for the enhanced photocatalytic oxidative desulfurization of dibenzothiophene
Authors: Hosseini-Sarvari Mona , Saki Saeede , Gu Yanlong , Zheng Dengyue
Published: December 2022

CdS@NH2-MIL-125 nanocomposite was synthesized via an in situ solvothermal strategy, fully characterized and investigated as a photocatalyst for oxidative desulfurization of dibenzothiophene.
Tris-decorated multi-iron polyoxotungstates
Authors: Izarova Natalya V. , Faassen Fabian , Kögerler Paul
Published: December 2022

When attached to Wells–Dawson-type iron polyoxotungstates, Tris ligands adopt an unprecedented chelating mode, accompanied by the formation of a novel {Fe6O24} substructure.
Correction: An integrated nucleic acid detection method based on a microfluidic chip for collection and culture of rice false smut spores
Authors: Yang Ning , Ji Yuanyuan , Wang Aiying , Tang Jian , Liu Shuhua , Zhang Xiaodong , Xu Lijia , He Yong
Published: December 2022

Correction for ‘An integrated nucleic acid detection method based on a microfluidic chip for collection and culture of rice false smut spores’ by Ning Yang et al., Lab Chip, 2022, https://doi.org/10.1039/d2lc00931e.
Morphological evolution of poly(glycerol monomethacrylate)-stat-glycine–phenylalanine–phenylalanine–methacrylamide-b-poly(2-hydroxypropylmethacrylate) (P(GMA-stat-(MAm-GFF))-b-PHPMA) block copolymer nano-objects via polymerization-induced self-assembly
Authors: Dao T. P. Tuyen , Vezenkov Lubomir , Subra Gilles , Amblard Muriel , Ladmiral Vincent , Semsarilar Mona
Published: December 2022

Here we report a study on the reversible addition–fragmentation chain transfer (RAFT) polymerization-induced self-assembly (PISA) of self-assembling peptide-containing diblock copolymers.
Image encryption based on fractional discrete cosine transform and DWT with interplane arrangements in dost domain
Authors: Sundaram Gaurav , Panna Bhaskar , Jha Rajib Kumar , Kumar Sumit
Published: December 2022

In this paper, a novel color image encryption scheme based on fractional discrete cosine transform (FrDCT) and discrete wavelet transform (DWT) with interplane arrangements in the discrete orthonormal Stockwell transform (DOST) domain is presented. Color images are encrypted using the keys of FrDCT and coefficients of interplane arrangement of DWT sub‐bands. These keys are applied on three independent planes, that is, R, G, and B. To ensure the correct decryption of the encrypted image, every key need to be clearly understood in the correct sequence and its exact values. FrDCT has the advantageous feature of storing real‐valued coefficients, and the energy of the image can be represented with very few coefficients. Therefore, transmitting and storing the encrypted image becomes easy. FrDCT may be considered a real‐valued cosine version of fractional Fourier transform (FrFT), which is used successfully for storage and transmission due to its property of compacting energy distribution. Furthermore, for more robustness, interplane arrangements are explored. The concept of interplane arrangements has not been substantially reported in the existing literature. The comparison of the technique with other similar encryption techniques available in the literature has been carried out by performing different experiments to examine the efficacy of the proposed method. It is found that the proposed method outperforms other existing techniques.
Combining the CLAUDS and HSC-SSP surveys
Authors: Desprez G. , Picouet V. , Moutard T. , Arnouts S. , Sawicki M. , Coupon J. , Gwyn S. , Chen L. , Huang J. , Golob A. , Furusawa H. , Ikeda H. , Paltani S. , Cheng C. , Hartley W. , Hsieh B. C. , Ilbert O. , Kauffmann O. B. , McCracken H. J. , Shuntov M. , Tanaka M. , Toft S. , Tresse L. , Weaver J. R.
Published: December 2022

We present the combination of the Canada-France-Hawaii Telescope (CHFT) Large AreaU-bands Deep Survey (CLAUDS) and the Hyper-Suprime-Cam (HSC) Subaru Strategic Program (HSC-SSP) data over their four deep fields. We provide photometric catalogs foru, u*(CFHT-MegaCam),g,r, i, z, andy(Subaru-HSC) bands over ~20 deg2, complemented in two fields by data from the Visible and Infrared Survey Telescope for Astronomy (VISTA) Deep Extragalactic Observations (VIDEO) survey and the UltraVISTA survey, thus extending the wavelength coverage toward near-infrared with VIRCAMY, J, H, andKsobservations over 5.5 deg2. The extraction of the photometry was performed with two different softwares: the HSC pipelinehscPipeand the standard and robustSExtractorsoftware. Photometric redshifts were computed with template-fitting methods using the newPhosphoroscode for thehscPipephotometry and the well-knownLe Pharecode for theSExtractorphotometry. The products of these methods were compared with each other in detail. We assessed their quality using the large spectroscopic sample available in those regions, together with photometry and photometric redshifts from COSMOS2020, the latest version of the Cosmic Evolution Survey catalogs. We find that both photometric data sets are in good agreement inUgrizydown to magnitude ~26, and to magnitude ~24.5 in theYJHKsbands. We achieve good performance for the photometric redshifts, reaching precisions of σNMAD≲ 0.04 down tomi~25, even using only the CLAUDS and HSC bands. At the same magnitude limit, we measured an outlier fraction ofη≲ 10% when using theUgrizybands, and down toη≲ 6% when considering near-infrared data. ThehscPipeplusPhosphorospipeline performs slightly worse in terms of photometric-redshifts precision and outlier fraction than itsSExtractorplusLe Pharecounterpart, which has essentially been tracked down to differences in the photometry. Thus, this work is also a validation of thePhosphoroscode. The photometric catalogs with the data and photometric redshifts from the two pipelines are presented and made publicly available.
Strukturierendes Vorgehen in der Balintgruppe – Perspektiven
unter Online-Bedingungen
Authors: Gesmann Mechthild
Published: December 2022

In der Durchführung einer Balintgruppe unter Online-Bedingungen scheint
eine Anpassung der Vorgehensweise für den Gruppenprozess erforderlich zu
sein. Ein vertrauensbildender Anfangskontakt fördert die Kommunikation
zwischen den Teilnehmenden und der Gruppenleitung. Die Strukturierung der
Fallbesprechung ermöglicht eine wertschätzende und lebendige
Gruppeninteraktion. Ziele der Balintgruppenarbeit in den Bereichen Empathie,
Toleranz und Verständnis können auch im Online-Setting erreicht
werden.
Far-Lateral Approach for Foramen Magnum Meningioma: An Anatomical Study with Special Reference to Bulbopontine Junction
Authors: Beucler Nathan , Haikal Christelle , Sellier Aurore , May Adrien , Meyer Mikael , Fuentes Stéphane
Published: December 2022

Intracranial meningiomas are sometimes located anteriorly to the foramen magnum and can cause disabling long tract symptoms. The far-lateral approach has been developed to provide an extensive view over the bulbopontine junction and the surrounding lower cranial nerves and upper spinal nerves with a good control on the vertebral artery, allowing the safe resection of such tumors. It is the report of a case with anatomical study before and after the removal of the meningioma. The use of the far-lateral approach allowed us to (1) control the vertebral artery in its V3 (Atlantic extradural) and V4 (intradural) portion (2) have an optimal visibility on the lower cranial nerves, the upper spinal nerves, and the bulbopontine junction, and (3) perform a Simpson 2 resection of the tumor that was inserted between the lower clivus and the upper odontoid process. Beyond its interest for the safe resection of tumors located anteriorly to the foramen magnum, the far-lateral approach is of particular anatomical interest. It allowed us to review the anatomy of the craniocervical junction.
Size-dependent thermal capacity of graphene nano-ribbons
Authors: Ligatchev Valeri
Published: December 2022

The “discretized” version of the two-dimensional “Generalized Skettrup Model” is presented and implemented at simulations on the effect of alterations in the aspect ratio(s) of rib lengths on temperature-dependent harmonic and anharmonic specific lattice thermal capacities of rectangular graphene nano-ribbons. The obtained simulation results are discussed in comparison with appropriate experimental data and their counterparts reported elsewhere for the square graphene flakes [V. Ligatchev, ECS J. Solid State Sci. Technol. 9, 093014 (2020); V. Ligatchev, “Generalized Skettrup Model” and Lattice Thermal Capacity of Spatially Non-Homogeneous and Low-Dimensional Semiconductors and Insulators. Lambert Academic Publishing, Saarbrücken, Germany, 2021].
A multi-layered comparative analysis of English-medium instruction in the Netherlands
Authors: van der Hoeven Dymphi , Duarte Joana
Published: December 2022

The rise of English in Dutch higher education has been accompanied by a language ideological debate that affects students’ and lecturers’ lives at the micro level, policy and planning at the meso (institutional) level and is related to the macro perspective (national political agenda). This study explores how language ideologies and attitudes play a role in this debate by comparing lecturers’ perceptions of the use of English in higher education to general language ideologies reflected in the Dutch printed press. A thematic analysis was conducted, including a three-dimensional investigation incorporating a vertical approach (macro, meso, micro) combined with a horizontal approach focusing on ideological themes present at the vertical level. Our data consist of 151 news items and 20 interviews with lecturers in higher education. Results show that monolingual language ideologies are the norm in both the perceptions of teaching staff and the Dutch media. Lecturers were generally more positive towards the exclusive use of English than the printed media. The study suggests that the Dutch/English dichotomy and accompanying persistence of a monolingual language ideology contrast with the reality of the Netherlands as a multilingual community. Implications for language policy and practice within EMI are presented.
Copper alumina reinforced poly(aniline-co-indole) nanocomposites for optoelectronic devices
Authors: Sankar S. , Furhan  , George Ajith , Ramesan M. T.
Published: December 2022

Copper alumina (Cu-Al2O3) reinforced poly(aniline- co-indole) (PANI- co-PIN) nanocomposites were prepared and characterised by UV-vis spectroscopy, FE-SEM and DSC. The bandgap energy decreased with the addition of Cu-Al2O3 to PANI- co-PIN. The FE-SEM confirms the uniform dispersion of nanoparticles in the copolymer. The DSC showed a shift in glass transition temperatures to higher regions with Cu-Al2O3 concentrations. The frequency-temperature-dependent dielectric parameters and electrical conductivity of nanocomposites were investigated. Activation energy calculated from Arrhenius equation decreases with increasing frequency. The real and imaginary part of electric modulus implies the thermally activated dielectric relaxations. The decreasing radius of semicircles in Nyquist plot with increasing temperatures indicates the existence of thermally activated conduction mechanisms. Different theoretical models were used to predict the DC conductivity mechanism in copolymer nanocomposites.
The FMRFamide-like peptide FLP-1 modulates larval development by regulating the production and secretion of the insulin-like peptide DAF-28 in Caenorhabditis elegans
Authors: Une Risako , Kageyama Natsumi , Ono Masahiro , Matsunaga Yohei , Iwasaki Takashi , Kawano Tsuyoshi
Published: December 2022

The FMRFamide-like peptides (FLPs) are conserved in both free-living and parasitic nematodes. This molecular genetic study verified the relevance of the flp-1 gene, which is conserved in many nematode species, to the larval development of the free-living soil nematode Caenorhabditis elegans. Using C. elegans as a model, we found that: (1) FLP-1 suppressed larval development, resulting in diapause; (2) the secretion of FLP-1, which is produced in AVK head neurons, was suppressed by the presence of food (Escherichia coli) as an environmental factor to continue larval development; (3) the FLP-1 reduced the production and secretion of DAF-28, which is produced in ASI head neurons and is the predominant insulin-like peptide (INS) present. FLP-1 is conserved in many species of plant–parasitic root-knot nematodes that cause severe damage to crops. Therefore, our findings may provide insight into the development of new nematicides that can disturb their infection and development.