bluuebunny/crossref_metadata_2025 huggingface dataset:
Seismic Design of Bridges for Prevention of Girder Pounding
Authors: H. Hao  , N. Chouw
Published: August 2022

In design of conventional bridges the gap between bridge spans is usually only a few centimetres. For such an expansion joint poundings between adjacent bridge girders during strong earthquake shaking are usually unavoidable. Pounding often causes damages to girders. In extreme situations it may push one of the bridge decks off the support. In this work a new design philosophy using a modular expansion joint (MEJ) is introduced. So far MEJs have been used mainly to cope with large thermal expansion and contraction of long bridges. For proper design of bridges to avoid the consequence of poundings under strong earthquakes not only a minimum total gap but also the maximum opening movement of the joint are essential. In this study the simultaneous effect of varying vibration properties of adjacent bridge spans, spatially varying ground excitations and soil-structure interaction on the total closing and opening movements of a MEJ, required to eliminate possible pounding and to ensure the join in perfect working order, is estimated, and the main influence factors are discussed.
Trans-Obturator Tape(TOT) Cerrahi Uygulamasının Kadın Üriner İnkontinans ve Kadın Cinsel Fonksiyonları Üzerindeki Etkisi
Authors: Altınkaya Nurullah , Sönmez Mehmet Giray
Published: August 2022

Amaç: Bu çalışmanın amacı, Trans-Obturator Tape(TOT) cerrahi uygulamasının kadın üriner inkontinans
ve kadın cinsel fonksiyonları üzerindeki etkisinin araştırılmasını amaçlamaktır.
Yöntemler: Ocak 2018-Temmuz 2021 tarihleri arasında transobturator tape(TOT) cerrahisi uygulanan
hastalar çalışmaya dahil edildi. Preoperatif dönemde ve postoperatif 3. ayda Uluslararası Standartlaştırılmış
Kadın Cinsel İşlev İndeksi(FSFI), Uluslararası İnkontinans Sorgulama Formu(ICIQ-SF), Aşırı Aktif Mesane
Değerlendirme Formu(OAB-V8) ve Ürogenital Distres Envanteri(UDI-6) anketleri uygulandı. Preoperatif
ve postoperatif veriler karşılaştırıldı.
Bulgular: Çalışmaya TOT cerrahisi uygulanan toplam 37 hasta dahil edildi. Hastaların ortalama yaşı
58.6±7.1 yıl idi. Ortalama takip süresi 15, 2±4.8 ay olarak saptandı. 22(%59,5) hastanın en az bir adet
ek hastalığı mevcuttu. FSFI, ICIQ-SF, OAB-V8, UDI-6 skorlarının preoperatif dönemdeki değerlerinin
postoperatif dönemde düzelme yönünde anlamlı değişiklik gösterdiği saptandı. (sırasıyla p<0.001,
p<0.001, p<0.001, p<0.001)
Sonuç: Trans-Obturator Tape(TOT) cerrahi uygulaması kadın stres üriner inkontinansını azaltmakta olup
kadın cinsel işlevi üzerinde de olumlu etkilerde bulunmuştur. Ayrıca TOT cerrahisi sonrası başlanan β3-
adrenoseptör agonisti olan Mirabegron tedavisinin cerrahi sonrası gelişen aşırı aktif mesane semptomlarını
azalttığı görülmüştür.
Anahtar Kelimeler: Üriner inkontinans, stres inkontinans, transobturator tape, kadın cinsel fonksiyon
bozukluğu
Evaluation of Clinical and Radiological Findings of Patients Diagnosed Spontaneously Intracerebral Hematoma
Authors: Arıkan Erhan
Published: August 2022

Amaç: Spontan intraserebral hematom, genellikle hipertansif değişikliklere bağlı, serebral vasküler
yapıların rüptürü sonucu serebral parankim içine kanama olmasıdır. İnmelerin sık nedenlerinden olup,
mortalite ve morbiditesi oldukça yüksektir. Bu çalışmamızda acile başvuran spontan intraserebral
hematomlu olguların demografik, klinik ve radyolojik özelliklerini literatür ışığında analiz ettik.
Yöntemler: Bu çalışma, spontan intraserebral hematom tanısı konulan 27’si kadın ve 36’sı erkek olmak
üzere toplam 63 hasta üzerinde retrospektif olarak yapıldı. Hastaların; yaş, cinsiyet, eşlik eden sistemik
hastalıklar, oral antikoagülan kullanımı, başlangıç GKS’u, nörolojik muayane bulguları, hematomun
lokalizasyonu, hematomun volümü gibi verileri incelendi.
Bulgular: 63 hastanın %57’si erkek idi. Hastaların %62’si 65 yaş ve üstü idi. Sistemik hastalıklar içinde en
sık eşlik eden %46 ile hipertansiyondu. Hastaların %29’u oral antikoagülan kullanıyordu. Sıklıkla bilinç
değişikliği (%44) ve motor defisit (%44) ile başvurdular. Hastaların geliş GKS’si % 55 oranında 13- 15
puan arasındaydı. Bilgisayarlı tomografi görüntüleri incelendiğinde hematomların en sık lobar (%47)
yerleşimli olduğu izlendi. Hematomların %56’sının volümü 30 cm3’ün altındaydı.
Sonuç: Spontan intraserebral hematom tanısında, demografik, klinik ve radyolojik özelliklerin dikkatle
incelenmesi oldukça önemlidir. Çalışmamızın retrospektif analizindeki verilerin literatür ile büyük ölçüde
paralellik gösterdiğini saptadık.
Anahtar Kelimeler: Acil servis, retrospektif, spontan intraserebral kanama
Granülomatöz Apendisit
Authors: Eren Karanis Meryem İlkay , Küçükosmanoğlu İlknur , Şahin Alparslan
Published: August 2022

Granülomatöz apandisit nadirdir ve apendektomi materyallerinin %2’sinden azında görülür. Granülomatöz apandisitin enfeksiyöz ve nonenfeksiyöz birçok nedeni vardır. Karın ağrısı, mide bulantısı, ateş şikayetiyle acil servise başvuran 22 yaşında erkek hastanın fizik muayenesinde rebaund, defans saptanmıştır. Lökosit 12590/mm3 idi. Ultrasonografide apendiks çapı 14 mm ölçülmüştür. Apendiks tümörü düşünülen hastaya sağ hemikolektomi + omentektomi + mezenterik lenf nodu diseksiyonu yapılmıştır. Duvarı kalınlaşmış, lümeni genişlemiş ve nekrotik hal almış olan apendiksten hazırlanan kesitlerde akut ve kronik yangısal infiltrasyon ve az sayıda granülom yapısı görülmüştür. ‘‘Granülomatöz apandisit’’ olarak raporlanan olgu cerrahi rezeksiyon dışında tedavi almamıştır, beş yıldır takip edilen hastanın ek şikayeti olmamıştır. Granülomatöz apandisitlerin %5-10’u Crohn hastalığına bağlıdır. Apendikste granülomatöz yangı yapan diğer nedenler arasında yersinia enfeksiyonu, tüberküloz, sarkoidoz, aralıklı apandisit, yabancı cisim reaksiyonu, fekalite bağlı tıkanıklıklar, divertikülit, mukosel ve tümör yer almaktadır. Granülomatöz apandisit tanısı alan hastalar ganülomatöz apandisit yapan nedenler yönünden araştırılmalı ve özellikle Crohn hastalığı açısından uzun dönem takip edilmelidir.
Anahtar Kelimeler: Apendiks, granülomatöz apandisit, crohn hastalığı
A Rare Disease with Unique Findings: ROR2-Associated Autosomal Recessive Robinow Syndrome
Authors: Keçeci Hayriye Nermin
Published: August 2022

Robinow sendromu (RS), ayırt edici kraniyofasiyal özellikler, iskelet anormallikleri ve diğer anomalilerle karakterize, otozomal dominant (DRS) ve resesif (RRS) kalıtılan konjenital bir iskelet displazisidir. Sebep olan genler heterojendir. Robinow sendromunun tüm tipleri genel olarak benzer klinik özelliklere sahip olsa da, bazı genotip-fenotip korelasyonları vardır. Burada amacımız diş tedavisi için başvuran, dismorfik özellikler nedeniyle pediatrik genetik polikliniğine sevk edilen ve ROR2'ye bağlı Robinow sendromu tanısı alan 11 yaşındaki kadın hastanın klinik bulgularını tanımlamaktır.
Anahtar Kelimeler: Otozomal resesif, çarpık dişler, mezomeli, robinow sendromu, ROR2, skolyoz
White Spot Lesions and Remineralization
Authors: Khatri Monisha , Kishore Shreya , Nagarathinam S. , Siva Suvetha , Barai Vanita
Published: August 2022

As all practitioners are aware, the prevalence and incidence of dental caries keep increasing constantly and therefore early diagnosis and cessation of further progression would greatly help in maintaining the sound tooth structure. One of the earliest signs of dental caries is a white spot lesion, which is mostly missed, and only treated when the condition worsens. WSL are areas of demineralized enamel that occur due to a prolonged period of retained microbial biofilms most commonly associated in patients with poor oral hygiene and fixed orthodontic appliances. If caught early and intervened, WSLs can be reversed. Therefore, the diagnosis and treatment of WSL are of outmost importance, and this chapter will explain in detail various methods of diagnosing WSLs, its treatment protocol with the significance of remineralization of the same.
Minimally Invasive Microneedle: A Novel Approach for Drug Delivery System and Infected Wound Care Management
Authors: Pramanick Bidhan , G. Patil Aishwarya
Published: August 2022

Chronic wound healing has become an area of fundamental research. Wound healing for a diabetic patient is one of the significant challenges in the biomedical field. Diabetes is a globally challenging disease that has affected around 400 million people. Many therapeutic factors are introduced to treat chronic wounds, with minimal success due to difficulty in delivery of the drug to the wound location. Microneedle patches are considered an efficient medical treatment procedure to address wound healing problems. The wound healing is accelerated, and the bacterial infection is inhibited by the devices based on microneedle with the loaded active drugs (including hemostatic drugs, bacterial drugs, and anti-inflammatory drugs). The wound healing process is generally divided into three steps: inflammation, proliferation, and tissue remodeling. This chapter will discuss the significant challenges and the advantages of microneedle applications in chronic wound healing.
Probability to Be Involved in a Road Accident: Transport User Socioeconomic Approach
Authors: Antonio Obregón Biosca Saúl , Luis Reyes Araiza José , Angel Pérez Lara y Hernández Miguel
Published: August 2022

Road education is one of the most relevant issues focused to reduce traffic accidents, so it is important to analyze the driver’s behavior on the roads. International research has found evidence for a relationship between socioeconomic characteristics and traffic accidents. In this sense, the chapter shows a methodology to estimate the probability to be involved in a road accident, considering the road education and the socioeconomic characteristics of the population of a specific region, taking the Santiago de Querétaro city (in México) as a study case. Through a logit model estimation and a survey applied to pedestrian, cyclist, motorcyclist, car driver, and freight driver allow us to determine which socioeconomic variables and road education are significant to determine the probability of being involved in a road accident.
Fatigue Behavior of Reinforced Welded Hand-Holes in Aluminum Light Poles with a Change in Detail Geometry
Authors: R. Rusnak Cameron , C. Menzemer Craig
Published: August 2022

Welded aluminum light poles often contain hand-holes. These hand-holes are used to give access for electrical wiring installation and maintenance purposes. Wind load may cause light poles to be loaded in a cyclic manner. This cyclic loading can cause localized fatigue cracking around the hand-hole. Fatigue failure around hand-holes has been observed in the field, but studies surrounding the resistance of the hand-holes are few and far between. This study included four-point bending fatigue tests on welded aluminum poles containing hand-holes. Eight welded aluminum specimens, each with two hand-holes, were tested in fatigue. These 16 details were loaded at the same stress range. Each specimen had a slightly different geometry or treatment applied to the hand hole. These different details mimicked traditional reinforced hand holes, similar to those evaluated in previous studies. Changes in the treatment and/or geometry included milling the inside of hole, milling the inside of the hole as well as the cast insert prior to welding, and milling the cast insert itself prior to welding. Among the 16 details tested, 15 failed as a result of fatigue cracking. It was found that specimen failure would originated in the throat of the fillet weld and then proceeded to propagate into the reinforcement ring/casting. A finite element analysis was used in addition to the experimental study.
Construction and Modification of Copper Current Collectors for Improved Li Metal Batteries
Authors: Luo Shunrui , Pei Kai
Published: August 2022

Metallic Lithium have gained great attention for its high theoretical specific capacity. But continuous growth of Li dendrites upon cycling might cause low coulombic efficiency and serious security issues. Construction of advanced 3D Cu current collectors to regulate Li plating/stripping and improve battery performance is considered as one effective promising strategy. In this chapter, we will discuss the roles and requirements of current collectors in lithium metal batteries. Then methods (dealloying, powder-sintering and 3D printing) employed for construction of 3D Cu current collector and implementation of surface modification (lithiophilic sites and coating layers) will be illustrated. At last, future opportunities of Cu current collectors will be lifted out.
Influence of Maternal Exercise on Maternal and Offspring Metabolic Outcomes
Authors: Jevtovic Filip , May Linda
Published: August 2022

Epigenetic transmission of metabolic disease to an offspring increases their risk for development of metabolic disease later in life. With the increasing rates of obesity in women of child-bearing age it is critical to develop strategies to prevent perpetuating metabolic disease across generations. Maternal exercise during gestation imprints offspring metabolic phenotype, thus increasing their imperviousness to metabolic assaults later in life. In rodent models, maternal exercise before and during gestation leads to enhanced offspring glycemic control, mitochondrial bioenergetics, and lower adiposity, which decreases their risk for development of future metabolic disease. In humans, maternal gestational exercise decreases pregnancy complications and improves maternal and offspring metabolism on both the whole-body and the cellular level. Maternal exercise restores the obesity-induced metabolic derangements, restoring maternal and offspring metabolic phenotype. While unknown, different exercise modalities might have a differential effect, however, evidence remains scarce.
Free legal aid for victims of gender-based violence from the perspective of lawyers
Authors: Turanjanin Veljko , Čanović Jelena
Published: August 2022

The paper deals with the right to free legal aid for victims of gender-based violence in the Republic of Serbia. The Law on Free Legal Aid entered into force in November 2019, and after two and a half years, there are certain shortcomings in the implementation visible in practice. The paper is divided into several parts, and the authors explain the background of the research in the introductory considerations, emphasizing the key legal provisions that were the subject of the research, after which the main part of the paper presents the results of the research conducted in the first quarter of 2022. The questionnaire sent to lawyers contained 22 questions, with a focus on providing free legal aid to victims of gender-based violence, for the period since November 1, 2019. The results show that the legal framework, but also the practice of providing free legal aid by local governments, is not at a satisfactory level.
Coronavirus: Global rebalances or the final threshold for the West?
Authors: López Víctor
Published: August 2022

The years 2018 and 2019, for international relations and global trade, were wavering from a trade war between the two largest superpowers today, which caused a significant drop in world growth and that redefined the strategy for both China and for the United States: between multilateralism and protectionism, reconfiguring new alliances, but finally, generating a truce between both countries that ended in the signing of an agreement in early 2020. However, the optimism at the beginning of this year quickly ended with the appearance of a virus - baptized as COVID-19 - which, although it originated in the city of Wuhan, in China, has been one of the great global equalizers. Unlike humans, viruses don't care where their victims come from, what religion they follow, or what ideology they believe in. Everyone is at risk, and as economies close and resources are depleted, the dynamics of international power may see a shift in the coronavirus era.
The use of drone technology in the auditing profession
Authors: Jakovljević Nemanja
Published: August 2022

The use of drone technology has significant potential for wider and mass application in the auditing profession, primarily in the implementation of audit engagement in the domain of the auditor's obligation to attend the inventory if they are material from the point of view of audited financial statements. The audit of inventories aims to examine and confirm the accuracy of the statements of the responsible persons in the entity that is the subject of the audit of the financial statements of the stated inventories. The aim of this paper is to research the attitudes of persons engaged in auditing towards the use of drone technology in the auditing profession with an emphasis on the use of drones in order to conduct stock audits. The research was conducted through a questionnaire that was advertised through publicly available mechanisms that include social networks and business contacts. The main conclusion of the paper is that there is an interest of persons engaged in auditing for the use of drone technology in the auditing profession, with concerns about the costs of its use and its legal regulation for use in auditing as evidence of management's assertions on inventories in financial statements. There is a greater interest in the use of drone technology among auditors employed by large international audit firms than by auditors working in smaller local audit firms or self-employed auditors.
Sport, games and chivalry in medieval Serbia
Authors: Zarković Božidar
Published: August 2022

Sports games held during the ancient times were an important factor that influenced the entire social life of the era. During the greatest sport events such as the Olympic Games, all hostilities and war conflicts ceased and the winners of the games were considered to be equal to gods. Although developed on the foundations of the Greek culture and Roman state, the Middle Ages, under the influence of Christianity, banned the Olympics considering them a pagan relic, making most sports undesirable. The invasion of barbarians, which destroyed the remnants of the old society, accelerated this process. Yet, not all sports activities died out. The ones related to everyday activities, fighting and warfare continued to live. Serbian medieval state originated in the area between Byzantium and Western Europe and was exposed to influences from both sides, both the East and West. These influences were also manifested in sports, games and chivalry. The influences' paths varied, though, and were connected to population's travelling and mixing. Thus, the Eastern influence came from the Byzantine neighboring cities, and the Western from the Westerners - the Sas (Saxon) miners who worked and lived in Serbia, merchants and craftsmen from the coastal region, as well as mercenary military squads hired by the rulers. Sports activities, games and knightly competitions in medieval Serbia were connected with other social events and could be found in mixed environment such as urban settlements, as well as at gatherings at certain religious buildings. Gatherings in the cities were connected with organization of trade fairs and trade shows, and at monasteries and churches with religious festivals held almost every day. Preserved onomastic materials testify about sports activities: igrište (arena), potecište (starting point), strelište (shooting range) and others. Sports activities and knightly competitions were of a competitive nature, whereas the games were for fun. The paper discusses the presence of sports activities, games and chivalry in medieval Serbia, their origin, venues and social significance.
Niševljanka as a small town originated urban folk dance
Authors: Đorđevic Nenad , Uzunović Slavoljub
Published: August 2022

The subject of this paper are city (small town) folk dances in a broader sense and Niševljanka folk dance as a town game in a narrower sense. The aim of the paper was to describe Niševljanka as a town folk dance. The basic task is to write down the music, rhythm and technique of the dance. In the available literature dealing with the systematization and division of folk dances, city folk dances are nowhere to be found as a special type of dance. Maybe rightly so, since they can be traced back to the traditional, original dances. However, given the conditions and time of the origin of these dances, with the migration of the peasantry to the towns and cities, the city dances in some way distanced themselves from the traditional ones. This was influenced by new living conditions, more cramped space, mixtures of the European and Oriental culture, as well as the Europeanization of culture and way of life in general. It can be stated that city folk dances are in fact traditional - original dances that have taken on other aspects of dancing and dancing behavior. If any folk dance has marked our city, and the state in general, from the end of the 19th and the beginning of the 20th century, it is undoubtedly Niševljanka folk dance. Numerous manuscripts, books, travelogues, newspaper articles from that time testify to this fact. This paper is an attempt to point this out and to find in one place the musical, rhythmic and playful record of this, undoubtedly original city folk dance.
BehaviorDEPOT is a simple, flexible tool for automated behavioral detection based on markerless pose tracking
Authors: Gabriel Christopher J , Zeidler Zachary , Jin Benita , Guo Changliang , Goodpaster Caitlin M , Kashay Adrienne Q , Wu Anna , Delaney Molly , Cheung Jovian , DiFazio Lauren E , Sharpe Melissa J , Aharoni Daniel , Wilke Scott A , DeNardo Laura A
Published: August 2022

Quantitative descriptions of animal behavior are essential to study the neural substrates of cognitive and emotional processes. Analyses of naturalistic behaviors are often performed by hand or with expensive, inflexible commercial software. Recently, machine learning methods for markerless pose estimation enabled automated tracking of freely moving animals, including in labs with limited coding expertise. However, classifying specific behaviors based on pose data requires additional computational analyses and remains a significant challenge for many groups. We developed BehaviorDEPOT (DEcoding behavior based on POsitional Tracking), a simple, flexible software program that can detect behavior from video timeseries and can analyze the results of experimental assays. BehaviorDEPOT calculates kinematic and postural statistics from keypoint tracking data and creates heuristics that reliably detect behaviors. It requires no programming experience and is applicable to a wide range of behaviors and experimental designs. We provide several hard-coded heuristics. Our freezing detection heuristic achieves above 90% accuracy in videos of mice and rats, including those wearing tethered head-mounts. BehaviorDEPOT also helps researchers develop their own heuristics and incorporate them into the software’s graphical interface. Behavioral data is stored framewise for easy alignment with neural data. We demonstrate the immediate utility and flexibility of BehaviorDEPOT using popular assays including fear conditioning, decision-making in a T-maze, open field, elevated plus maze, and novel object exploration.
Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases
Authors: Mehta Ved , Khanppnavar Basavraj , Schuster Dina , Kantarci Ilayda , Vercellino Irene , Kosturanova Angela , Iype Tarun , Stefanic Sasa , Picotti Paola , Korkhov Volodymyr M
Published: August 2022

Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well established, the function of their transmembrane (TM) regions remains unknown. Here, we describe the cryo-EM structure of Cya bound to a stabilizing nanobody at 3.6 Å resolution. The TM helices 1–5 form a structurally conserved domain that facilitates the assembly of the helical and catalytic domains. The TM region contains discrete pockets accessible from the extracellular and cytosolic side of the membrane. Neutralization of the negatively charged extracellular pocket Ex1 destabilizes the cytosolic helical domain and reduces the catalytic activity of the enzyme. The TM domain acts as a functional component of Cya, guiding the assembly of the catalytic domain and providing the means for direct regulation of catalytic activity in response to extracellular ligands.
Artificially stimulating retrotransposon activity increases mortality and accelerates a subset of aging phenotypes in Drosophila
Authors: Rigal Joyce , Martin Anduaga Ane , Bitman Elena , Rivellese Emma , Kadener Sebastian , Marr Michael T
Published: August 2022

Transposable elements (TEs) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Whether TE activity is simply a by-product of heterochromatin breakdown or can contribute toward the aging process is not known. Here, we place the TE gypsy under the control of the UAS GAL4 system to model TE activation during aging. We find that increased TE activity shortens the life span of male Drosophila melanogaster. The effect is only apparent in middle-aged animals. The increase in mortality is not seen in young animals. An intact reverse transcriptase is necessary for the decrease in life span, implicating a DNA-mediated process in the effect. The decline in life span in the active gypsy flies is accompanied by the acceleration of a subset of aging phenotypes. TE activity increases sensitivity to oxidative stress and promotes a decline in circadian rhythmicity. The overexpression of the Forkhead-box O family (FOXO) stress response transcription factor can partially rescue the detrimental effects of increased TE activity on life span. Our results provide evidence that active TEs can behave as effectors in the aging process and suggest a potential novel role for dFOXO in its promotion of longevity in D. melanogaster.
Prevalence of Aerobic Organisms in Surgical Site and Ulcerations at a Tertiary Rural Hospital in Mandya, Karnataka, India
Authors: D’Souza Rochelle , Shekar Shilpashree Channasandra , Gowda Suhas Narayanswamy , Naveen N
Published: August 2022

Introduction: In an era in which the cost of treatment is an increasing source of concern in wound management in surgery, wound infection increases costs and hospital stay. Aim: To study the microbial spectra, antibiotic sensitivity, different modalities of wound management and the outcome of treatment in surgical side infections and ulcerations. Materials and Methods: This cross-sectional study was conducted at a tertiary rural centre with a total of 60 cases of wounds with various aetiologies for duration of two years at AIMS, Mandya, Karnataka, India, from January 2020 to December 2021 to study demographics, prevalence and management outcome. Categorical data was represented in the form of frequencies and proportions. Results: Total 60 wound cases were further divided into three groups with 20 patients each having non specific ulcer, Surgical Site Infection (SSI) and Diabetic Ulcers (DU). The SSI was most common in patients belonging to age group 20-31 years. A total of 65% of patients who had SSI were observed among clean contaminated surgeries. Methicillin Resistant Coagulase Negative Staphylococci (MRCNS) was the most common organism causing infection in postoperative wounds, showing maximum sensitivity to vancomycin and resistance to amoxicillin. A 70% of the diabetic wounds underwent skin grafting and 70% of SSI patients underwent secondary suturing and 75% patients having an Arterial or Venous ulcers (A/V) were allowed to heal by secondary intention. Conclusion: A thorough understanding of microbial spectra and their antibiotic sensitivity is required in addition to effective wound management to improve the outcome of ulcer management.
IMPLEMENTASI ISAK 35 UNTUK PENYUSUNAN LAPORAN KEUANGAN SEKOLAH BAGI ANGGOTA HIMPAUDI MUSTIKAJAYA
Authors: Nurdiniah Dade , Meita Iren , Oktapriana Chita
Published: August 2022

HIMPAUDI perlu memiliki pengetahuan tentang penyusunan laporan keuangan. Mengingat latar belakang peserta yang bukan berasal dari akuntansi, tentu saja memiliki keterbatasan pengetahuan terkait dengan penyusunan laporan keuangan sekolah yang berbasis ISAK 35. Tujuan utama kegiatan PkM ini adalah memberikan pelatihan dan pemahaman implementasi ISAK 35 dalam penyusunan laporan keuangan sekolah. Pelaksanaan kegiatan pengabdian kepada masyarakat ini dilakukan dengan pendekatan metode service learning yang terbagi dalam tiga kali pelaksanaan dengan durasi tiga minggu. Pelaksanaan kegiaatan yang terjadi dalam kondisi pandemi COVID-19 memiliki beberapa keterbatasan namun tetap dapat diberlakukan secara tatap muka dalam beberapa kesempatan. Pertemuan tatap muka dilaksanakan dengan tetap memperhatikan protokol kesehatan dan pemberlakuan batasan PPKM wilayah. Selama pelaksanaan pelatihan diberikan serangkaian pre test dan post test untuk mengevaluasi tingkat pemahaman peserta. Terdapat peningkatan pemahaman rata-rata peserta setelah mengikuti pelatihan sebesar 59% untuk penerapan ISAK 35 pada laporan keuangan. Dari serangkaian penugasan peserta yang dibagi dalam beberapa kelompok kerja yang diberikan didapati hasil 80% peserta berhasil menyusun laporan keuangan berbasis ISAK 35 dengan benar. Selain itu, untuk mengukur tingkat kepuasan peserta dalam pelatihan, maka disebarkan pula kuisioner kepuasan. Dengan jumlah 45 peserta, terlihat dari hasil isian kuisioner kepuasan mitra didapati 68% peserta merasa sangat puas dengan kegiatan yang diikuti ini.
PENDAMPINGAN MANAJEMEN USAHA DAN MANAJEMEN KEUANGAN PADA UMKM BAKUL KEMBANG OFFICIAL KELURAHAN KEDURUS KECAMATAN KARANG PILANG KOTA SURABAYA
Authors: Jamil Mochamad , Mutmainnah Dewi , Azizah Muftiyatul
Published: August 2022

Usaha Mikro, Kecil, dan Menengah (UMKM) sebagai penyumbang Produk Domestik Bruto (PDB) Nasional memiliki peran penting bagi pemulihan ekonomi Indonesia sebagai dampak pandemi Covid-19, sehingga perlu adanya manajemen usaha dan manajemen keuangan yang tepat untuk memajukan suatu UMKM. Kegiatan Pengabdian Kepada Masyarakat (PKM) dilakukan pada mitra UMKM Bakul Kembangan Official yang kegiatan usahanya berbasis handmade, dengan varian produk flower bouquet: dry flowers, fresh flowers, framegift, hampers, macrame, money bouquet, mahar perkawinan dan lainnya yang pasarkan melalui berbagai media digital. Tujuan dari kegiatan PKM ini adalah memberikan pemahaman mengenai manajemen usaha agar memiliki arah, terukur dan terencana dengan baik, juga mengenai pengelolaan keuangan, agar kegiatan perencanaan, pengelolaan, penyimpanan, serta pengendalian dana dapat mendukung kegiatan dan pengembangan usaha mitra UMKM, sebagai hasil pendampingan dan pelatihan secara aplikatif. Metode pelaksanaan kegiatan ini melalui tahapan pra kegiatan, yakni melakukan survey awal, identifikasi permasalahan, konsolidasi Tim dalam melakukan pemetaan dan distribusi tugas sesuai dengan kepakaran, penyusunan dan pengajuan porposal kegiatan. Tahap pelaksanaan yaitu diskusi dan konsultasi, paparan materi pelatihan Manajemen Usaha dan Manajemen Keuangan dengan pratikum pembukuan sederhana. Tahap evaluasi dan monitoring, yakni dengan melakukan komparasi kondisi sebelum dan setelah kegiatan program dengan pendekatan interview dan diskusi serta observasi. Tahap akhir dilakukan penyusunan laporan dengan target publikasi dan dipaparkan dalam simposium kegiatan pengabdian kepada masyarakat.
Early Death After Chemotherapy as a Quality Indicator—Is It Time to Bench the Benchmark?
Authors: Dunn Catherine , Gately Lucy , Gibbs Peter
Published: August 2022

This Viewpoint examines chemotherapy at the end of life as a quality metric.
Exploring the Steric Hindrance of Alkylammonium Cations in the Structural Reconfiguration of Quasi‐2D Perovskite Materials Using a High‐throughput Experimental Platform
Authors: Zhang Jiyun , Wu Jianchang , Langner Stefan , Zhao Baolin , Xie Zhiqiang , Hauch Jens A. , Afify Hany A. , Barabash Anastasia , Luo Junsheng , Sytnyk Mykhailo , Meng Wei , Zhang Kaicheng , Liu Chao , Osvet Andres , Li Ning , Halik Marcus , Heiss Wolfgang , Zhao Yicheng , Brabec Christoph J.
Published: August 2022

Reduced‐dimensional (2D or quasi‐2D) perovskites have recently attracted considerable interest due to their superior long‐term stability. The nature of the intercalating cations plays a key role in determining the physicochemical properties and stability of the quasi‐2D perovskites. Here, the thermal stability of a series of 2D Ruddlesden−Popper (RP) perovskites is studied using seven types of intercalating cations with increasing linear carbon‐chain length from ethylammonium (EA) to n‐dodecylammonium (DA) through a high‐throughput platform. The results show that long‐chain cations in quasi‐2D perovskite films lead to strong steric hindrance between adjacent perovskite domains, thus suppressing Ostwald ripening during the thermal‐aging process. For short‐chain cations, increased‐dimensional phase redistribution during the aging period is observed, which can benefit a concomitant regeneration of the 3D/3D‐like perovskite phases. The impact of steric hindrance on structural reconfiguration and the subsequent phase redistribution in quasi‐2D perovskites are systematically characterized by UV–vis absorption spectra, photoluminescence spectra, and X‐ray diffraction patterns. Due to the steric hindrance effect, an optimal chain length is found to maximize film stability by balancing the water/oxygen resistance and increased‐dimensional phase redistribution. This study provides new insight into the thermal stability of quasi‐2D perovskites.
Tailored Biocompatible Polyurethane‐Poly(ethylene glycol) Hydrogels as a Versatile Nonfouling Biomaterial
Authors: Speidel Alessondra T. , Chivers Phillip R. A. , Wood Christopher S. , Roberts Derrick A. , Correia Inês P. , Caravaca April S. , Chan Yu Kiu Victor , Hansel Catherine S. , Heimgärtner Johannes , Müller Eliane , Ziesmer Jill , Sotiriou Georgios A. , Olofsson Peder S. , Stevens Molly M.
Published: August 2022

Polyurethane‐based hydrogels are relatively inexpensive and mechanically robust biomaterials with ideal properties for various applications, including drug delivery, prosthetics, implant coatings, soft robotics, and tissue engineering. In this report, a simple method is presented for synthesizing and casting biocompatible polyurethane‐poly(ethylene glycol) (PU‐PEG) hydrogels with tunable mechanical properties, nonfouling characteristics, and sustained tolerability as an implantable material or coating. The hydrogels are synthesized via a simple one‐pot method using commercially available precursors and low toxicity solvents and reagents, yielding a consistent and biocompatible gel platform primed for long‐term biomaterial applications. The mechanical and physical properties of the gels are easily controlled by varying the curing concentration, producing networks with complex shear moduli of 0.82–190 kPa, similar to a range of human soft tissues. When evaluated against a mechanically matched poly(dimethylsiloxane) (PDMS) formulation, the PU‐PEG hydrogels demonstrated favorable nonfouling characteristics, including comparable adsorption of plasma proteins (albumin and fibrinogen) and significantly reduced cellular adhesion. Moreover, preliminary murine implant studies reveal a mild foreign body response after 41 days. Due to the tunable mechanical properties, excellent biocompatibility, and sustained in vivo tolerability of these hydrogels, it is proposed that this method offers a simplified platform for fabricating soft PU‐based biomaterials for a variety of applications.
Detection of Single Nanoparticles inside a Single Terahertz Resonator
Authors: Bahk Young-Mi , Kim Kyoung-Ho , Ji Gangseon , Ahn Kwang Jun , Kim Dai-Sik , Park Hyeong-Ryeol
Published: August 2022

With the rapid advancement of 5G/6G communications using millimeter wavelengths, the concomitant usage of these long wavelength radiation for remote sensing and monitoring of biological and chemical agents is anticipated. However, the ability to detect and identify these agents with sizes ranging from nanometers to microns is hampered by its millimeter wavelength, which drastically reduces the interaction cross‐section. Herein, it is reported that single gold nanoparticles (NPs) drop‐casted on the nanoresonator can be observed by monitoring the far‐field transmitting spectra of individual terahertz (THz) nanoresonators, which enhance the electric field hundreds of times on the nanoscale. Despite the enormous mismatch in length scales, full‐wave 3D numerical modeling of the single THz nanoresonator is also performed to interpret the experimental results, indicating the possibility to turn off the resonance using only one NP embedded in the hotspot of the nanoresonator. Such NP detection becomes the most sensitive when the particle, whose size is comparable to the gap width, is tightly fitted into the nanoresonator. This work unveils the potential associated with refractive index sensing and hyperspectral absorption spectroscopy for detecting and fingerprinting ultra‐low density of bio/chemical molecules such as viruses, lipid vesicles, and explosives.
Development and verification of coarse‐grain CFD‐DEM for nonspherical particles in a gas–solid fluidized bed
Authors: Zhou Lianyong , Ma Huaqing , Liu Zihan , Zhao Yongzhi
Published: August 2022

Computational fluid dynamics coupled with discrete element method (CFD‐DEM) has been widely used to understand the complicated fundamentals inside gas–solid fluidized beds. To realize large‐scale simulations, CFD‐DEM integrated with coarse‐grain model (CG CFD‐DEM) provides a feasible solution, and has led to a recent upsurge of interest. However, when dealing with large‐scale simulations involving irregular‐shaped particles such as biomass particles featuring elongated shapes, current CG models cannot function as normal because they are all developed for spherical particles. To address this issue, a CG CFD‐DEM for nonspherical particles is proposed in this study, and the morphology of particles is characterized by the super‐ellipsoid model. The effectiveness and accuracy of CG CFD‐DEM for nonspherical particles are comprehensively evaluated by comparing the hydrodynamic behaviors with the results predicted by traditional CFD‐DEM in a gas–solid fluidized bed. It is demonstrated that the proposed model can accurately model gas–solid flow containing nonspherical particles, merely the particle dynamics are somewhat lost due to the scaleup of particle size. Finally, the calculation efficiency of CG CFD‐DEM is assessed, and the results show that CG CFD‐DEM can largely reduce computational costs mainly by improving the calculation efficiency of DEM. In general, the proposed CG CFD‐DEM for nonspherical particles strikes a good balance between efficiency and accuracy, and has shown its prospect as a high‐efficiency alternative to traditional CFD‐DEM for engineering applications involving nonspherical particles.
A comparative analysis of endoscopic sinus surgery versus biologics for treatment of chronic rhinosinusitis with nasal polyposis
Authors: Miglani Amar , Soler Zachary M. , Smith Timothy L. , Mace Jess C , Schlosser Rodney J.
Published: August 2022

Background

Comparative effectiveness research between endoscopic sinus surgery (ESS) and biologic therapy for severe chronic rhinosinusitis with nasal polyposis (CRSwNP) is a nascent field as new therapeutic modalities become clinically available.

Methods

A prospective, multicenter cohort of CRSwNP patients, undergoing ESS between 2011 and 2019, were compared to phase‐3 biologic trial data. Patients undergoing ESS received baseline nasal endoscopy quantified via Lund‐Kennedy (LK) grading. Patients meeting inclusion criteria, modified from Dupilumab‐LIBERTY‐NP‐24&52, omalizumab‐POLYP‐1&2, and Mepolizumab‐SYNAPSE clinical trials, were included in this study. Baseline characteristics and outcome measures were compared between these cohorts at 24 weeks and 52 weeks, when possible.

Results

A total of 111 CRSwNP patients met modified inclusion criteria. There were no statistically significant differences in baseline age, sex, asthma status, aspirin‐exacerbated respiratory disease status, smell identification, LK‐polyp score, and Lund‐Mackay computed tomography (CT) scores between ESS and biologic groups. At 24 weeks, ESS demonstrated significantly greater improvements in 22‐item Sino‐Nasal Outcome Test (SNOT‐22) compared to one (of two) dupilumab trials (p < 0.05) and both omalizumab trials (p < 0.001). ESS associated with significantly lower nasal polyp scores (NPS) compared to dupilumab (p < 0.001) and omalizumab (p < 0.001), despite comparable improvements in smell identification (p > 0.05). At 52 weeks, ESS resulted in statistically similar improvement in SNOT‐22 scores compared to dupilumab (p = 0.21), but NPS remained significantly lower in the ESS group compared to dupilumab (p < 0.001) and mepolizumab (p < 0.001).

Conclusion

At 24 weeks and 52 weeks, ESS offers comparable SNOT‐22 improvements compared to dupilumab. ESS and dupilumab offer comparable improvement in smell identification at 24 weeks. Compared to omalizumab, ESS offers superior SNOT‐22 improvements. ESS offers significantly greater reductions in polyp size compared to omalizumab, dupilumab, and mepolizumab therapies.
Stability Analysis of Isotropic Spheres in Einstein Gauss–Bonnet Gravity
Authors: Yousaf Z. , ul Haq Bhatti Muhammad Zaeem , Khan Suraj
Published: August 2022

This work investigates the effect of electromagnetic field on relativistic compact stellar structures coupled with anisotropic collapsing fluid under the framework of string‐motivated Gauss–Bonnet‐powered gravity. Using the power‐law form of Maxwell‐GB corrections, the stellar structure equations dubbed as Tolman–Oppenheimer–Volkoff (TOV) equations are developed. In the presence of a power‐law form of ‐corrections, an evolution equation for the Weyl scalar is obtained, which plays a central role in the investigation of the examined fluid configuration. It is observed that the existence of shear in the fluid flow, irregularities in the distribution of energy density, dissipative fluxes, and modified Gauss–Bonnet corrections are the certain factors that are accountable for generating anisotropies in an originally isotropic fluid distribution. Some of the interesting consequences of formulated results are examined.
Space‐Confined Donor‐Acceptor Strategy Enables Fast Spin‐Flip of Multiple Resonance Emitters for Suppressing Efficiency Roll‐Off
Authors: Liu Yang , Xiao Xin , Huang Zhenmei , Yang Dezhi , Ma Dongge , Liu Junjie , Lei Bowen , Bin Zhengyang , You Jingsong
Published: August 2022

Multi‐resonance boron‐nitrogen‐containing thermally activated delayed fluorescence (MR‐TADF) emitters have experienced great success in assembling narrowband organic light‐emitting diodes (OLEDs). However, the slow reverse intersystem crossing rate (kRISC) of MR‐emitters (103–105 s−1) that will lead to severe device efficiency roll‐off has received extensive attention and remains a challenging issue. Herein, we put forward a “space‐confined donor‐acceptor (SCDA)” strategy to accelerate RISC process. The introduction of SCDA units onto the MR‐skeleton induces intermediate triplet states, which leads to a multichannel RISC process and thus increaseskRISC. As illustrated examples, efficient MR‐emitters have been developed with a sub‐microsecond delayed lifetime and a highkRISCof 2.13×106 s−1, which enables to assemble high‐performance OLEDs with a maximum external quantum efficiency (EQEmax) as high as 32.5 % and an alleviated efficiency roll‐off (EQE1000: 22.9 %).
Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Platinum(II) Triphenylamine Complexes for Cancer Immunotherapy
Authors: Ling Yu‐Yi , Xia Xiao‐Yu , Hao Liang , Wang Wen‐Jin , Zhang Hang , Liu Liu‐Yi , Liu Wenting , Li Zhi‐Yuan , Tan Cai‐Ping , Mao Zong‐Wan
Published: August 2022

Activation of the cyclic GMP‐AMP synthase‐stimulator of the interferon gene (cGAS‐STING) pathway is a potent anticancer immunotherapeutic strategy, and the induction of pyroptosis is a feasible way to stimulate the anticancer immune responses. Herein, two PtIIcomplexes (Pt1andPt2) were designed as photoactivators of the cGAS‐STING pathway. In response to light irradiation,Pt1andPt2could damage mitochondrial/nuclear DNA and the nuclear envelope to activate the cGAS‐STING pathway, and concurrently induce pyroptosis in cancer cells, which evoked an intense anticancer immune response in vitro and in vivo. Overall, we present the first photoactivator of the cGAS‐STING pathway, which may provide an innovative design strategy for anticancer immunotherapy.
Formation and Reactivity of a Fleeting NiIII Bisphenoxyl Diradical Species
Authors: Awasthi Ayushi , Leach Isaac F. , Engbers Silène , Kumar Rakesh , Eerlapally Raju , Gupta Sikha , Klein Johannes E. M. N. , Draksharapu Apparao
Published: August 2022

Cytochrome P450s and Galactose Oxidases exploit redox active ligands to form reactive high valent intermediates for oxidation reactions. This strategy works well for the late 3d metals where accessing high valent states is rather challenging. Herein, we report the oxidation of NiII(salen) (salen=N,N′‐bis(3,5‐di‐tert‐butyl‐salicylidene)‐1,2‐cyclohexane‐(1R,2R)‐diamine) with mCPBA (meta‐chloroperoxybenzoic acid) to form a fleeting NiIII bisphenoxyl diradical species, in CH3CN and CH2Cl2 at −40 °C. Electrochemical and spectroscopic analyses using UV/Vis, EPR, and resonance Raman spectroscopies revealed oxidation events both on the ligand and the metal centre to yield a NiIII bisphenoxyl diradical species. DFT calculations found the electronic structure of the ligand and the d‐configuration of the metal center to be consistent with a NiIII bisphenoxyl diradical species. This three electron oxidized species can perform hydrogen atom abstraction and oxygen atom transfer reactions.
Simultaneous Generation of Methyl Esters and CO in Lignin Transformation
Authors: Liu Mingyang , Han Buxing , Dyson Paul J.
Published: August 2022

Lignin is an abundant renewable carbon source. Due to its complex structure, utilization of lignin is very challenging. Herein, we describe an efficient strategy for the simultaneous utilization of lignin, in which the methoxy groups in lignin react with carboxylic acids to generate methyl carboxylates and the other alkyl and phenyl carbons react with oxygen to predominantly form CO that can be used directly in carbonylation reactions. The method was applied to the methylation of various functionalized aryl and alkyl carboxylic acids, including natural compounds, to produce valuable chemicals, including pharmaceuticals. No solid or liquid residues remain after the reaction. Mechanistic studies demonstrate that a well‐ordered C−C and C−O bond activation sequence takes place to realize total transformation of lignin. This work opens a way for transformation of the entire lignin polymer into valuable products, exemplified by the synthesis of the pharmaceutical, Ramipril, on a gram scale.
Fano Resonance in Single‐Molecule Junctions
Authors: Zheng Yan , Duan Ping , Zhou Yu , Li Chuan , Zhou Dahai , Wang Yaping , Chen Li‐Chuan , Zhu Zhiyu , Li Xiaohui , Bai Jie , Qu Kai , Gao Tengyang , Shi Jia , Liu Junyang , Zhang Qian‐Chong , Chen Zhong‐Ning , Hong Wenjing
Published: August 2022

The Fano resonance in single‐molecule junctions could be created by interaction with discrete and continuous molecular orbitals and enables effective electron transport modulation between constructive and destructive interference within a small energy range. However, direct observation of Fano resonance remains unexplored because of the disappearance of discrete orbitals by molecule‐electrode coupling. We demonstrated the room‐temperature observation of Fano resonance from electrochemical gated single‐molecule conductance and current–voltage measurements of a para‐carbazole anion junction. Theoretical calculations reveal that the negative charge on the nitrogen atom induces a localized HOMO on the molecular center, creating Fano resonance by interfering with the delocalized LUMO on the molecular backbone. Our findings demonstrate that the Fano resonance in electron transport through single‐molecule junctions opens pathways for designs of interference‐based electronic devices.