bluuebunny/crossref_metadata_2025 huggingface dataset:
¿Qué debe saber, hacer y ser el diseñador industrial de la UACJ del mañana?
Authors: Castellanos Uralde Marlen , Almaraz Córdova Claudia , Ríos Alonso Raúl Alejandro
Published: December 2022

Las carreras de Diseño Industrial, internacionalmente, se construyen sobre el dominio de habilidades por parte del estudiante que están respaldadas por conocimientos y cuyo ejercicio implica una extrema sensibilidad y valores humanos. En Ciudad Juárez, Chihuahua, México, la investigación titulada “Sistema de Competencias Profesionales para el Diseñador Industrial en la UACJ Visión 2030”, de la cual forman parte los autores del presente artículo, se realiza en el marco de la preparación para la reacreditación de esta, como parte de la evaluación institucional. El objetivo de la presente propuesta es arrojar un directorio con interconexiones sistémicas que funcione, en última instancia, como herramienta de trabajo y orientación para estudiantes, profesores y directivos. Este artículo muestra las habilidades, capacidades y valores detectados como parte del estudio teórico llevado a cabo por los autores acerca de las competencias profesionales a ser desarrolladas por el estudiante de Diseño Industrial que egrese de la UACJ, con visión a 2030. Las competencias profesionales se presentan en forma de sistema, estructurado en elementos y unidades, que incluyen los conocimientos, las habilidades y el sistema de valores para la formación de los diseñadores industriales. Las indagaciones empíricas realizadas por los autores de esta investigación, en el diagnóstico del estado actual, a través de entrevistas, encuestas y el análisis documental, permiten corroborar la necesidad de la identificación del sistema de competencias.
El Circo de la Física: Actividades lúdicas en la divulgación de la física
Authors: Castrejón Parga Karen Yael , Sáenz Villela Jesús Manuel
Published: December 2022

Este trabajo describe de una manera cualitativa cómo se presentan los conceptos y demostraciones físicas en El Circo de la Física, uno de los ejemplos a nivel mundial de este tipo de actividad de divulgación científica. También se discuten la filosofía y la manera en la que se conducen las actividades, así como algunas de las problemáticas en la introducción de conceptos de la física. Este trabajo describe cómo se facilita la comprensión de los conceptos al presentar aproximaciones, en lugar de ser abordados de forma rigurosa dada la gran diversidad de edades y niveles educativos del público. Se dan algunos ejemplos de las demostraciones y algunas sugerencias para su implementación. También, se describen las experiencias adquiridas en base a las aportaciones usuales de los asistentes que han participado en alguna de las presentaciones llevadas a cabo a lo largo de más de veinte años en México. Finalmente, se discute el trabajo a futuro para evaluar actividades de divulgación de este tipo.
Effect of Income Level on Stroke Incidence and Mediated Effects of Medication Adherence in Newly Diagnosed Hypertensive Patients: A Causal Mediation Analysis Using a Nationwide Cohort Study in South Korea
Authors: Jeong Seungmin , Kong So Yeon , Hwang Seung-sik , Cho Sung-il
Published: December 2022

Objectives: This study aimed to determine the associations between income level and stroke incidence in hypertensive patients. We also tried to measure the mediating effect of poor antihypertensive medication adherence through causal mediation analysis. Methods: This study used the National Health Insurance Service National Sample Cohort Data from 2006 to 2015. The study population was newly diagnosed patients with hypertension aged 18 to 80. The associations between the independent-dependent variables, the mediator-dependent variables were confirmed with Cox proportional hazards regression models. In order to verify the mediating effect of poor hypertension medication adherence between income level and stroke occurrence, a weighting approach of causal mediation analysis method was used. Since age was the moderate variable, 18-49 years old and 50-80 years old were stratified. Results: Under 50 years of age, all the other income groups had a significantly higher risk of poor medication adherence than the highincome group. For the patients aged 50 and older, the low-income group and the Medical Aid beneficiaries had a higher risk of poor medication adherence compared to the high-income group. In the patient under 50 years of age, the risk for the stroke incidence of the low-income group and the Medical Aid beneficiaries were higher than those in the high-income group. In the patients aged 50 and older, all the other income groups had a significantly higher risk of incidence of stroke. Causal mediation analysis showed that the mediated effect of poor medication adherence in all groups was not significant. Conclusions: Low income significantly increased poor hypertension medication adherence and the incidence of stroke. The mediated effect of poor medication adherence was not significant.
Prevalence of Loneliness and Its Association with Marital Status in Korean Adults: Analysis of the Korean Welfare Panel Study Data in 2021
Authors: Song Inmyung
Published: December 2022

Objectives: Loneliness poses a serious health risk. However, little is known about the state of loneliness in the Korean population. This study analyzes the prevalence of and risk factors for loneliness with a particular focus on marriage status in Korean adults using nationwide survey data. Methods: Using individual-level data from the 16th Korean Welfare Panel Study in 2021, this study analyzed 9,422 participants aged 30 years and older, who responded to a question, “how many days during the past week did you feel lonely as if you were alone in the world?”. Multiple logistic regression analysis was conducted to examine the likelihood of feeling lonely at least once a week according to marital status and other sociodemographic characteristics (gender, education level, household income status, employment status). Multivariate-adjusted odds ratio (OR) and 95% confidence intervals (CI) were calculated. Subgroup analysis was conducted by sex. Results: 20.2% of the study population were estimated to have felt lonely at least one day a week. 52.4% of widowed individuals and 47.6% of the divorced reported being lonely. Widowed and single people were more than two times as likely to feel lonely as the married (OR=2.60 for the widowed; OR=2.43 for the single; p<0.001). Divorce and separation increased the odds of feeling lonely (OR=4.02; 95% CI, 3.20-5.04; p<0.001). ORs for loneliness for all non-married statuses (widowed, divorced/separated, single) were greater in men than in women. Conclusions: Loneliness is a highly prevalent public health problem in Korean adults. Marital status was strongly associated with increased risk for loneliness. Public health policies should consider targeting individuals who are more susceptible to the risk of loneliness.
Respons Pertumbuhan Benih Makadamia terhadap Dosis Pupuk N, P,dan K
Authors: Sakiroh Sakiroh , Sasmita Kurnia Dewi , Firdaus Nurkholis , Listyati Dewi , Pranowo Dibyo
Published: December 2022

Makadamia merupakan tanaman introduksi yang belum banyak dikembangkan di Indonesia, oleh karena itu perlu digali informasi tentang suplai hara N, P, dan K yang tepat mulai dari perbenihan sampai tanaman berproduksi dalam menunjang pertumbuhan dan produktivitas tanaman yang optimal pada tanah suboptimal di Indonesia. Penelitian ini bertujuan untuk mengetahui dosis pupuk N, P, dan K yang optimal untuk pertumbuhan dan perkembangan benih makadamia. Penelitian menggunakan Rancangan Acak Lengkap dengan perlakuan 5 kombinasi dosis pupuk N, P, dan K yaitu: P1 (tanpa pupuk/kontrol), P2 (1,09 g Urea + 1,39 g SP36 + 0,84 g KCl)/benih, P3 (2,18 g Urea + 2,78 g SP36 + 1,67 g KCl)/benih, P4 (5,44 g Urea + 6,95 g SP36 + 4,17 g KCl)/benih dan P5 (8,15 g Urea + 10,42 g SP36 + 6,25 g KCl)/benih, dengan empat kali ulangan. Hasil penelitian menunjukkan adanya pengaruh nyata perlakuan terhadap pertambahan tinggi benih sampai umur 24 minggu setelah aplikasi (MSA) namun tidak berpengaruh nyata terhadap pertambahan diameter batang dan jumlah daun, serta klorofil daun. Dosis N, P, dan K pada perlakuan P3 menghasilkan pertambahan tinggi benih terbaik, menunjukkan dosis tersebut optimum untuk pertumbuhan benih makadamia sampai umur 13 bulan. Penelitian selanjutnya dapat diarahkan untuk mengetahui kebutuhan pemupukan N, P, dan K pada benih makadamia di atas umur 13 bulan sampai produksi pada tanah masam di Indonesia.
Early Literacy Learning for Future Library Paraprofessionals: Authentic Learning in Library Education
Authors: Mardhani-Bayne Alvina , Shamchuk Lisa
Published: December 2022

This article describes the professional learning around early literacy experienced by library paraprofessional students at a post-secondary institution in Canada. Students completed a survey to gauge their conceptions of early literacy at the beginning of a course on library services for children and young adults. These students then experienced hands-on, engaging course elements such as in-class discussions, guest speakers, and authentic assessments. At the conclusion of the course, students were again surveyed and were asked to identify course elements that contributed to their learning. Most students aligned with an emergent literacy approach to early literacy. While a comparison between the two surveys did not reveal a significant difference in terms of students’ conceptions of early literacy, multiple students identified the hands-on elements of the course as beneficial. The researchers conclude that providing authentic professional learning opportunities that include knowledge application reinforces learners’ conceptions about emergent literacy.
Universal Simulation Model of Battery Degradation with Optimization of Parameters by Genetic Algorithm
Authors: Dobrego K. V. , Koznacheev I. A.
Published: December 2022

Modeling of batteries is necessary to control their operating mode and diagnose their condition. It is important to model the life cycle, i. e. degradation of basic parameters over a long service life. This is due to the fact that the cost of buffering electricity by batteries is associated with their cycling resource, which can be increased by optimizing the mode of operation of the drive in the energy system. The existing models of battery degradation are characterized by specificity, limited work on standardized charge-discharge cycles, and mathematical cumbersomeness. The article proposes a universal approach devoid of the above disadvantages. The concept of continuous battery wear during the service life is used. A simple empirical model is presented that does not consider in detail the characteristics of the state of batteries during a separate charge-discharge cycle, and does not include voltaic variables. The model considers the intensity of the current wear of the battery as a function of the state of its charge, temperature, the current of the external circuit and the current of self-discharge, the full charge that has flowed through the battery since the beginning of its operation. In this case, the amount of wear (degradation) is determined by the integral of the function of the intensity of current wear over the battery life. To optimize the parameters of the model, a random search method is used in combination with a genetic selection algorithm. The corresponding model of degradation of parameters for the Delta GEL-12-55 lead-acid battery has been constructed, in which the data on degradation of capacity given in the technical description from the manufacturer are used. The efficiency of the parameter optimization algorithm and the adequacy of the resulting model are shown. The model developed by the authors can be used for technical and economic calculations of generator – storage –consumer systems, hybrid power storage systems, and compact representation of large volumes of experimental data on the degradation of specific batteries.
Analysis of the Efficiency of Technologies for Extraction Carbon Dioxide from Combustion Products
Authors: Sednin V. A. , Ignatovich R. S.
Published: December 2022

The main purpose of the article is to compare and analyze existing technologies for extracting carbon dioxide from combustion products in relation to mini-CHP plants operating on local fuels. The article presents a brief overview of the main technical features of the implementation of carbon dioxide extraction technologies from gas mixtures. The specific features and limitations for each of the methods are shown. Mathematical modeling of technological processes of adsorption, physical and chemical absorption is carried out on the basis of Aspen Hysys and Aspen Adsorption software packages. When modeling absorption processes, the composition of combustion products characteristic of the actual operating conditions of an energy source on wood chips was considered, while for the adsorption process, the composition of combustion products was simulated by a binary mixture of carbon dioxide and nitrogen with a molar content of 11 and 89 %, respectively. The results of numerical research that were obtained have shown that the highest degree of carbon dioxide extraction from combustion products is 97 %, and it is achieved in the optimal mode of implementation of chemical absorption technology. With the same method, the highest degree of purity of the resulting carbon dioxide is observed, viz. 86 % taking into account water vapor and 99 % if it is dry. The least effective technology for extracting carbon dioxide was the method of physical absorption in a fixed bed, in which the degree of purity of the resulting dry carbon dioxide was 79 %. Therefore, for practical use in the deep utilization of combustion products of mini-CHP plants operating on local fuels, to obtain carbon dioxide with a low content of impurities, it is necessary to apply the method of chemical absorption. The use of physical absorption technology in a fixed bed can be used to reduce energy source emissions or in cases where the degree of purity of carbon dioxide does not matter.
Interactive FEM education for load-bearing system static and dynamic analysises by case of the bionic tower of the Eddys- tone lighthouse
Authors: Dounar S. S. , Iakimovitch A. M. , Jatskevitch O. K. , Lapuka A. D.
Published: December 2022

FEM simulation of Eddystone lighthouse is provided. Incorporated bionic tower is modelled as well. Load cases including gravity force, wind thrust, water stream and 50-year wave impulse are accomplished. Stress concentrator system is described. Effect of tension stress concentrator compensation caused by gravity is showed. Low gradient stress dispensation is demonstrated for bionic tower outer surfaces. Recommendation touching places to monitor are given.

Methodic experience related to interactive one-command student – professor FEM simulation of responsible load-bearing systems is collected.
Mechanism and Prevention Technologies of Reservoir Gas Disaster in Abandoned Oil Well of Coal Mine
Authors: Shao Yawu , Suo Yonglu , Xiao Jiang , Li Qiannan , Yang Tao
Published: December 2022

The reservoir gas disaster has distinct characteristics and is a key factor that threatens the safe and green mining of coal mines in the costorage area of coal and petroleum resources. In order to solve the problem of prevention and control of reservoir gas disasters in coal mines, the characteristics of oil-bed gas disasters in abandoned oil wells in coal mines were analyzed, and the oil-bed gas disaster mechanism of abandoned oil wells without isolation coal pillars was revealed to study the scope of gas disasters around oil wells under the influence of production. The research shows that: (1) abandoned oil well reservoir gas disasters have the characteristics of high gas pressure, high concentration, large lateral influence area, wide vertical sweep range, and frequent disasters, which seriously threaten the safety and green mining of coal mines; (2) divide the reservoir gas disaster of abandoned oil wells into the high-pressure gas disaster in the well and the disaster in the surrounding oil-bed gas enrichment area; (3) according to the numerical simulation results that the maximum damage depth of the coal seam mining floor is 38.6 m and the seepage height of high-pressure oil-bed gas is 40 m, the safety factor k is introduced, and the reservoir gas sweeping range of the abandoned oil well is determined to be 95.4 m below the coal seam to the surface; (4) the comprehensive prevention and control technical scheme of oil-bed gas for controlling high-pressure oil-bed gas in wells by ground plugging and downhole injection and injection of diluent to control enriched areas was proposed, which successfully solved the problem of safe and efficient exploitation of Shuangma coal mine in Ningdong coalfield by abandoned oil wells. The research results provide effective solutions for the realization of green mining in many coal mines in the costorage area of coal and oil resources in China and have important application value for the prevention and control of dynamic disasters in the costorage area of resources.
Dimorfismo sexual en el estudio de la cavidad orbitaria y apertura piriforme mediante tomografías de haz cónico helicoidal en una muestra peruana
Authors:   , Suarez Ponce Daniel Guillermo
Published: December 2022

Objetivo: Determinar el dimorfismo sexual en el estudio de la cavidades orbitarias y apertura piriforme en tomografías de haz cónico helicoidal en una muestra de adultos peruanos. Materiales y métodos: Diseño transversal con una muestra conformada por 174 tomografías de haz cónico helicoidal (87 masculino y 87 femenino; 20 a 50 años) de una data de un centro radiológico privado de Lima. Se registró el sexo y se midieron la altura máxima, el ancho máximo y el área de la apertura piriforme y de la cavidad orbitaria derecha e izquierda. Se aplicó análisis inferencial con la prueba T de Student y funciones discriminantes para estimar el sexo. Resultados: Todos los parámetros fueron más altos en varones. Las funciones discriminantes individuales para estimar el sexo aumentaron con la combinación de los tres parámetros tanto en apertura piriforme (89%) como en cavidad orbitaria (87,4%). Se obtuvieron tres funciones discriminantes: apertura piriforme (df=0,351 x altura + 0,130 x ancho + 0,002 x área – 16,246), cavidad orbitaria derecha (df=0,335 x altura + 0,182 x ancho + 0,001 x área) e izquierda (df=0,374 x altura + 0,275 x ancho + 0,001 x área). Conclusión: La morfometría de cavidad orbitaria y apertura piriforme predijeron el dimorfismo sexual y pueden ser útiles en la práctica forense peruana.
Consideraciones jurídicas sobre la regulación en materia de gestión y manejo de residuos infecciosos y hospitalarios en el Perú como consecuencia del Covid-19
Authors:   , Lazabara Leguia Elena Lourdes , Hawkins Estrada Rodrigo
Published: December 2022

Como consecuencia de la pandemia originada por el SARS-COV 2 (“COVID-19”), denotamos la aparición de una problemática que no solo hace referencia al campo de la salud, sino que hace alusión a otros aspectos tales como el económico, social, político y, en mayor proporción, el ambiental. Así, dentro de este último aspecto, podemos encontrar la inadecuada gestión de los residuos infecciosos y hospitalarios. Es importante destacar que, con ocasión al estado de emergencia que venimos atravesando desde marzo del año 2020, se ha observado un aumento significativo en el empleo de mascarillas, guantes, entre otros implementos como medios de protección contra el COVID-19 así como también de residuos provenientes de nuestros hogares y de los EESS ( “EESS”). En razón a esto último, se ha generado nuestro interés por investigar sobre la correcta disposición de los residuos hospitalarios e infecciosos originados por la pandemia. Ante ello, a lo largo de nuestro artículo desarrollaremos las principales implicancias de la normativa sobre la disposición de estos desechos conforme a lo establecido en la Norma Técnica de Salud N°144-MINSA/2018/DIGESA, aprobado por Resolución Ministerial N° 1295-2018-MINSA y del Decreto Legislativo N° 1278, “Ley de Gestión Integral de Residuos Sólidos” y su Reglamento, así como también trataremos de dilucidar cuales son las competencias atribuibles a Dirección General de Salud Ambiental e Inocuidad Alimentaria (“DIGESA”) y las del Organismo de Evaluación y Fiscalización Ambiental ( “OEFA”), con la finalidad de proponer mejoras regulatorias para una adecuada gestión y disposición de dichos residuos.
Impacto de agroquímicos en la densidad poblacional y actividad biológica de la fauna edáfica de la finca Santa Adela - Cañete
Authors:   , Olortegui Izaguirre Flavia Ximena
Published: December 2022

La costa peruana tiene la menor extensión agrícola a comparación de la sierra y selva; no obstante, usa la mayor cantidad de plaguicidas. En la provincia de Cañete hace falta información cuantitativa sobre cómo se está afectando la salud de suelo por uso de estos insumos agrícolas; por eso, en el distrito de Nuevo Imperial, se seleccionó la finca Santa Adela para evaluar los parámetros físicos, químicos y biológicos del suelo, que incluyeron a microorganismos y lombrices. Los resultados indicaron la presencia de varios plaguicidas, incluyendo dos persistentes como Axozystrobin e Imidacloprid, junto con un suelo en proceso de salinización, con poca materia orgánica y bajo número de bacterias, actinomicetos y hongos a comparación del control; sin embargo, no se encontraron efectos adversos en lombrices. La eliminación de microorganismos sensibles junto con un uso energético ineficiente por organismos adaptados y resistentes altera no solo su estructura, sino también su funcionabilidad que puede traer consecuencias en los ciclos de nutrientes y en la calidad del suelo.
Metazoos parásitos de peces marinos y dulceacuícolas del Perú: un análisis basado en sus índices de especificidad de hospedero (IHS)
Authors:   , German Gomez Arianne Maria
Published: December 2022

Introducción: La especificidad de hospedero indica el número de hospederos que un parásito es capaz de infestar y es un término de interés dentro de la ecología de las enfermedades ya que permite identificar parásitos de aspecto zoonótico. Objetivo: Se determinó la especificidad de los metazoos parásitos de peces marinos y dulceacuícolas del Perú a partir de los índices de especificidad de hospedero (IHS). Métodos: Se realizó una revisión bibliográfica sobre metazoos parásitos de peces, para luego organizar los datos obtenido y finalmente aplicar los índices STD (distinción taxonómica), VarSTD (variación de la distinción taxonómica), STD* (distinción taxonómica con prevalencia) y βSPF (especificidad beta). Resultados: Los parásitos que presentaron una baja especificidad fueron parásitos marinos: Lecithocladium cristatum (tremátodo), Helicometra fasciata (tremátodo), Acanthochondria sicyasis (copépodo) (valores de STD cercanos a 5). Por el contrario, parásitos como Procamallanus (Spirocamallanus) pintoi (céstodo de agua dulce), Proleptus carvajali (nemátodo marino), Cynoscionicola americanus (monogeneo marino), Ceratothoa gaudichaudii (isópodo marino) y los copépodos Lernanthropus huamani, Caligus callaoensis y Bomolochus constrictus indicaban una alta especificidad. La ausencia de correlación entre el número de hospederos y los IHS (p>0.05) nos indica que la especificidad de hospedero no se encuentra sujeta a la cantidad de especies que el parásito infesto, sino a su capacidad para habitar un hospedero que le proporcione un ambiente óptimo y complete su ciclo. Los datos obtenidos nos permiten explicar la alta y baja especificidad de hospedero a partir de las migraciones de los parásitos y sus hospederos, así como desde un aspecto coevolutivo. Conclusiones: El presente estudio es el primero en emplear los IHS para evaluar parásitos acuáticos en el Perú; con ello, sentamos las bases para futuras investigaciones y resaltamos la importancia del estudio de los parásitos acuáticos.
Comprehensive analysis of HDAC7 expression and its prognostic value in diffuse large B cell lymphoma
Authors: Gao Tianqi , Lu Weiguo , Zhuang Guangyan , Li Yongcong , Zeng Qingli , Li Xiaozhen , Xiao Mingfeng
Published: December 2022

Background: HDAC7 is a class IIa histone deacetylase (HDAC) that exhibits lymph-specific expression patterns in the hematopoietic system. HDAC7 loss or dysregulation may lead to B cell-based hematological malignancies. This study aimed to explore the prognostic value of HDAC7 in patients with diffuse large B cell lymphoma (DLBCL).
Methods: RNA sequencing data and clinical information for HDAC7 in DLBCL were collected from The Cancer Genome Atlas (TCGA) database and analyzed using R software. Paired t and Mann–Whitney U tests were used to detect differences between DLBCL and adjacent normal tissues, and the pROC software package was used to generate receiver operator characteristic (ROC) curves to detect cut-off values for HDAC7. Data from paraffin-embedded specimens from the two groups were used for validation of external immunohistochemical (IHC) staining. The relationship between DLBCL and HDAC7 was explored by enrichment analysis using the Gene Oncology and Kyoto Encyclopedia of Genes and Genomesdatabases. The tumor immunity estimation resource (TIMER) and integrated repository portal for tumor-immune system interactions (TISIDB) databases were used to analyze the correlation between HDAC7 and DLBCL immune cell infiltration. Survival analysis of HDAC7 in patients with DLBCL was performed using the PrognoScan database.
Results: Compared with that in normal tissues, HDAC7 mRNA was overexpressed in DLBCL. The HDAC7 IHC scores of stage III and IV DLBCL patients were significantly lower than those of stageI and II DLBCL patients, which was associated with shorter overall survival (OS) and disease-specific survival (DSS). In addition, the higher expression of HDAC7 may play a role in the lower level of immune infiltration in DLBCL.
Conclusions: Downregulation of HDAC7 expression was correlated with poor prognosis and immune infiltration in DLBCL patients. This has potential as a novel marker for the prognosis of DLBCL patients.
Human Decellularized Endometrial Scaffold Seeded by Myometrial Smooth Muscle Cells Supports the Differentiation of Human Endometrial Mesenchymal Cells to Epithelial and Stromal Cells ​
Authors: Sargazi Zinat , Zavareh Saeed , Salehnia Mojdeh
Published: December 2022

Background: This study designed to evaluate the co-culturing of human mesenchymal endometrial cells (EMCs) and myometrial smooth muscle cells (MSMCs) in decellularized scaffold as a natural bioscaffold to formation of the endometrial-like structure.
Methods: After decellularization of the human endometrium, cell seeding was performed by centrifugation of human EMCs with different speeds and times in 15 experimental subgroups. Analysis of residual cell count in suspension was done in all subgroups and the method with the lower amount of suspended cells was selected for subsequent study. Then, the human EMCs and the MSMCs were seeded on the decellularized tissue and cultured for one week then, differentiation of the seeded cells was assessed by morphological and gene expression analysis.
Results: The cell seeding method by centrifuging at 7000 rpm for 2 minutes showed the highest number of seeded cells and the lowest number of residual cells in suspension. The endometrial-like structure formed and the epithelial-like cells had some protrusions on their surface and the stromal cells had spindle and polyhedral morphology. The MSMCs almost were homed at the periphery of mesenchymal cells similar to their arrangement in the native uterus. The expression of endometrial-related genes (SPP1, MMP2, ZO-1, LAMA2 and COL4A1) confirmed these observations. The low level of expression of the OCT4 gene as a pluripotency marker in seeded cells confirmed the differentiation of these cells.
Conclusion: This study showed that the co-culturing of human EMCs with the MSMCs on the decellularized scaffold could improve the formation of endometrial-like structures.
Long-term results of 107 cases undergoing posterior approach for transpedicular corpectomy with instrumentation and circumferential arthrodesis from a single-center
Authors: YILMAZ Murat , Ikizoglu Ersin , ARSLAN Mert , ERTEM Onder , ERBAYRAKTAR Serhat , YUCESOY Kemal
Published: December 2022

Study design: Retrospective cohort study.
Objectives: We aimed to evaluate the less morbid and efficacy of posterior transpedicular corpectomy and circumferential instrumentation using a cage or bone graft for thoracolumbar corpectomy.
Methods: This study was performed using the medical records of 107 consecutive patients treated surgically between June 1999 and July 2021. The patients suffering from spinal cord compression due to thoracolumbar vertebral pathologies as trauma, tumor, and osteomyelitis that involved T5 to L5 segments underwent posterolateral transpedicular corpectomy with or without sagittal balance reconstruction. Circumferential reconstruction was accomplished using either mesh cages or strut bone graft along with posterior instrumentation and fusion. The demographic data, clinical presentation, neuroradiological findings, surgical treatment methods, and therapeutic outcomes were analyzed.
Results: The average age was 51.03 (range: 17 to 76) years. The pathological fractures were due to primary or metastatic bone tumors in 80 (74.77%) cases, granulomatous infections in 16 (14.95%) cases, and trauma in 11 (10.28%) patients. There were no perioperative mortalities and the mean follow-up period was 48 months (range: 14 to 166 months). Therapeutic outcomes revealed satisfactory clinical recovery in all patients.
Conclusion: Transpedicular posterior corpectomy and circumferential construction is a proper, effective, and reliable surgical technique for a wide spectrum of thoracolumbar vertebral pathologies. Attributed to lower complication rates and shorter length of hospital stay compared to the anterior route, it must be considered in selected cases as an alternative to the difficult anterior approach.
Obesity in Refugees Post-resettlement in a High-income Country: A Meta-Analysis
Authors: Kibibi Niclette , Dena Isabelle , Cummings Precious de-Winton , Hicks Chelsea D. , Bao Wei , Schweizer Marin L.
Published: December 2022

Background
Resettled refugees have a lower risk of obesity at arrival but over time this risk increases. We systematically investigated the association between refugee status and obesity after resettlement in a high-income nation.
Methods
We searched PubMed, Embase, OpenGrey and bibliographies of retrieved articles, with no date, location, and language restrictions, for observational studies assessing obesity rates in resettled refugees compared to the host population.
Results
Nine studies were analyzed. We found no evidence of increased risk of obesity among refugees compared to the host population, with significant heterogeneity across studies. Only sub-analysis by sex showed a significantly increased risk of obesity among female refugees compared to the host population.
Discussion
Pooled analyses showed no increased risk of obesity among refugees in various host nations. However, the magnitude of the association between refugee status and obesity suggests a protective effect that should be explored further.
Reticulinasus salahi (Acarina: Argasidae), an ectoparasite of bats and man in the Palaearctic and Afrotropics: an annotated review of records with the first pathogens detected
Authors: Ševčík Martin , Špitalská Eva , Kabát Peter , Lučan Radek K. , Maliterná Michaela , Reiter Antonín , Uhrin Marcel , Benda Petr
Published: December 2022

The soft ticks of the genusReticulinasusSchulze, 1941 (family Argasidae Koch, 1844) are ectoparasites of various bat species of the Afrotropic, Australasian, and Oriental regions.Reticulinasus salahi(Hoogstraal, 1953) is the only representative of the genus that occurs in the western part of the Palaearctic. This unusual distribution reflects the home range of its primary host,Rousettus aegyptiacus(Geoffroy, 1810) from the family Pteropodidae. However, the complete summary of available records and a review of the host species, including re-determination of the originally reported hosts and new records, prove that this parasite occurs also in areas exceeding the distribution range ofR.aegyptiacus. Besides the primary host, the occurrence was confirmed also on bats of the families Vespertilionidae and Emballonuridae,Otonycteris hemprichiiPeters, 1859 andTaphozous perforatusGeoffroy, 1818. SinceO. hemprichiiandR. aegyptiacusforage in different habitats and also their natural roosts differ, the parasite transfer between them probably happened in a common roost in anthropogenous conditions. On the other hand, inT. perforatusthe transfer from the primary host species could be expected in a common underground roost either in natural or artificial conditions. Some of the tick specimens collected fromR. aegyptiacusbetween July 2010 and March 2012 in Jordan and Oman, were tested for pathogen presence. The MHV-68 virus and the bacteriaBorellia burgdorferiis.l. were found in the ticks from both countries. In the ticks from Jordan, the presence ofRickettsia slovaca-likewas confirmed, and CandidatusEhrlichia shimanensisin the larva from Oman. The anthropogenous occurrence ofR.salahicombined with the existence of its pathogens represents a potential health issue for human visitors of the bat roosts within the distribution range ofR.aegyptiacus.
Greenness assessment of developed derivative spectrophotometric method for simultaneous determination of ascorbic acid and folic acid in pharmaceutical formulation
Authors: Aziz Kayan S. , Qader Hemn A.
Published: December 2022

A simple, precise, green, and white analytical procedure have been developed for the simultaneous estimation of ascorbic acid and folic acid with the aid of the zero-crossing first derivative spectrophotometric technique. The standard solutions of ascorbic acid and folic acid were prepared in phosphate buffer (pH = 7). At the zero crossing points of folic acid (249.6 and 281) nm, ascorbic acid showed a measurable amplitude of the peak-to-baseline and linear over the concentration ranges of (0.17–12.0) µg/mL and (0.37–12) µg/mL with detection limits of 0.057 µg/mL and 0.121 µg/mL, respectively, while folic acid displayed an observable amplitude of the peak-to-baseline method at the zero-crossing point of ascorbic acid (265.6 nm), with (0.26–15.0) µg/mL and a detection limit of 0.088 µg/mL. The greenness of the proposed method was assessed based on white analytical chemistry (WAC), analytical greenness (AGREE), and green analytical procedure index (GAPI). The method was successfully applied for the simultaneous determination of ascorbic acid and folic acid in pharmaceutical formulation and synthetic laboratory mixtures with reasonable precision, accuracy, and recovery.
Assessing environmental and spatial drivers of non-marine ostracod metacommunities structure in Northern and Southern Patagonian environments
Authors: Coviaga Corina , Pérez A. Patricia , Ramos Lorena Y. , Zalazar Laura , García Patricia E. , Cusminsky Gabriela C.
Published: December 2022

Understanding the mechanisms structuring the metacommunities is a fundamental question in community ecology. Ostracods are an ideal study group for metacommunity studies, due to their environmental sensitivity, high dispersal capacity and increased use as biological proxy in (paleo-) ecology studies. We studied the contribution of environmental and spatial processes in structuring non-marine ostracod metacommunities in Northern and Southern Patagonia. A total of 37 ostracod species were found at the 105 environments studied. According to variation partitioning results, in Northern Patagonia the metacommunities were influenced by a combination of species sorting (environmental control, including non-spatial and spatial components) and spatial effects (e.g. dispersal limitation). While species sorting (environmental control, due to non-spatial components) was the principal mechanism structuring Southern Patagonia. Discrepancies between the degree of environmental and spatial control structuring ostracod metacommunities could be associated to differences in study areas extension and in sampled sites distances, more than differences in Ostracoda response. Instead, the spatial extent not influenced total beta diversity and their components between the studied areas. Our study expanded the understanding of the drivers affecting the non-marine ostracod metacommunities in Patagonia, Argentina. And also, about the variables structuring the ostracod assemblages. Increase the knowledge in these aspects have important implications for (paleo-) ecology studies, allowing trustworthy interpretations in biological assessment programs and paleoenvironmental interpretations.
The complex etiology of Epilepsy: Genetic analysis and HLA association in patients in the Middle East
Authors: Fadda Abeer , Alsabbagh Mohamed , Vasudeva Dhanya , Saeed Amira , Aglan Sara , Hubrack Satanay Z , Benini Ruba , Lo Bernice , Zamel Khaled
Published: December 2022

Epilepsy is one of the most common neurological disorders. The cost to the health system and the impact on quality of life for patients with intractable epilepsies and associated comorbidities is significant. Disease etiology and pathogenesis are still not well understood. Genetic mutations have been shown to be associated with 70% of epilepsies, with the majority being non-monogenic, and the remaining 30% enigmatic. This knowledge gap necessitates further research. The goal of this study is to partially bridge this gap through the genetic analysis of a cohort of patients with epilepsy from an understudied and highly consanguineous population, primarily of ethnicities from the Middle East and North Africa region. Whole exome sequencing was carried out in 81 patients with epilepsy and their family members at a tertiary center in Qatar. We used the data to identify pathogenic variants and type HLA alleles for 13 class I & II genes. We associated the resulting alleles with disease status, using controls of a closely related ethnicity. The genetic yield was approximately 22% for known epilepsy genes. We also suggest a list of 20 genes that could be culprits. Analysis of the biological pathways in which these genes are involved show that focal and generalized epilepsy genes are highly interwound. HLA analysis revealed that class II HLA genes are associated with disease status, particularly DRB4*03:01N, which plays a strong protective role. Our findings suggest that an immune etiology may contribute to the disease together with a genetic culprit, emphasizing the complexity of the etiology of the disease.
The Influence of Probe Curvature on Articular Cartilage Friction Measurements
Authors: Guo Emily , Henry Kaylin , Himmelmann Hannah K. , Chu Nolan , Hanson R. Reid , Schulze Kyle , Jackson Robert
Published: December 2022

The potential lubrication mechanisms for articular cartilage remain as complex as the material itself. Many studies have examined systematically the effects of sliding velocity on the frictional response of cartilage but a systematic analysis of contact area remains largely uncharted. Here we explore this potential effect three ways: a constant force experiment, a constant pressure experiment, and a non-constant pressure and force experiment. Hard, impermeable spheres are used as probes and with sizes varied between 1.6 mm and 25.4 mm allowing a sweep of physiologically relevant pressures. The aim is to effectively isolate the influence of the probe curvature on the friction measurements. Articular cartilage samples were collected from horses at necropsy from the left and right distal, medial aspect of the radius. Each test was run for five minutes at a reciprocated sliding speed of 1 mm/s. Two lubrication regimes are observed during testing, an area-dependent regime at lower areas and an area-independent regime at higher areas. Therefore measurements made using different probe sizes will most likely result in different measurements of the friction behavior and great care should be given when comparing these results.
Evaluating the Long- and Short Run Asymmetrical Effects of Climate Change on Crop Production: Empirical Evidence from Pakistan
Authors: Shar Rashid Usman , Qi Yin , Bughio Amanuallah , Jamali Riaz Hussain , Arthur Anita Afra
Published: December 2022

This study examines the long- and short-run asymmetrical effects of climate change on crop production by analyzing an annual time series from 1990 to 2019. In order to model the long-run and short-run cointegrations of a number of variables across time, as well as their causality directions, an ARDL (Autoregressive Distributed Lag) method was employed. The results of the study were also analyzed using a regression model in order to assess the reliability of the findings. As a preliminary result, a causal relationship between the variables, on a long-term basis, has been established using the Fully Modified Ordinary Least Squares (FMOLS), Canonical Cointegration Regression (CCR), and Vector Error Correction Model (VECM). The study found that crop production and carbon dioxide emissions in the country have a very strong relationship both on a short-term as well as a long-term basis, as well as showing a positive relationship between labor force, fertilizer use, and water availability over the long-term. A long-term analysis of the labor force, fertilizer use, and water availability shows a significant positive correlation between the three variables. As a result of the short-run study, several factors were positively and statistically significant, including carbon dioxide emissions, temperature, labor force, and fertilizer use. There was a significant influence of both climatic and non-climatic factors on Pakistan's crop production based on a paired Granger causality test. Based on the study's conclusions, Pakistan's policymakers must develop agricultural policies, strategies, and plans for the purpose of reducing carbon dioxide emissions, according to the conclusion of the study. Thus, by encouraging environmentally friendly farming methods, the country will be able to increase its efforts toward achieve sustainable agriculture. It is important for the country to promote environmentally friendly farming in order to achieve a sustainable agriculture industry.
Numerical Estimation Method for the Generalized Weibull distribution Parameters
Authors: Maswadah M.
Published: December 2022

In this study, a new estimation method using the Runge-Kutta iteration technique is presented to improve the maximum likelihood estimation method. The improved method has been applied to the generalized Weibull distribution, which is a member of a family of distributions (T-X family). The estimates of the generalized Weibull model parameters were derived using the Runge-Kutta, maximum likelihood, and Bayesian methods based on the generalized progressive hybrid censoring scheme, via a Monte Carlo simulation. The Simulation results indicated that the Runge-Kutta estimation method is highly efficient and outperforms the maximum likelihood estimation and Bayesian estimation methods based on the informative and kernel priors. Finally, two real data sets were studied to ensure the Runge-Kutta estimation method can be used very effectively than the most popular estimation methods in fitting and analyzing real lifetime data.
Analysis of the changes in intestinal lipid absorption after small bowel resection in mice
Authors: Sasaki Takato , Masumoto Kouji , Ono Kentarou , Goto Yudai , Nakagawa Yoshimi , Shimano Hitoshi
Published: December 2022

Purpose
Prolonged lipid malabsorption occurs after small bowel resection (SBR). We aimed to clarify the underlying mechanism using a mouse model.
Methods
SBR mice were created by resecting 50% of the proximal intestine. In sham mice, the intestine was transected and re-anastomosed. Intravenous nutrition was not initiated and mice were fed a liquid elemental diet followed by a solid standard rodent diet for one week each. Animals were sacrificed on postoperative day (POD)7 or POD14, and the following data were analyzed: body weight, caloric intake, histopathological findings, and the mRNA expression of genes related to intestinal lipid absorption in the remnant intestines (jejunum and ileum).
Results
SBR group showed significantly delayed body weight recovery, despite comparable caloric intake. A histopathological examination revealed increased villus height and deepening crypts in the remnant jejunum and ileum as “morphological adaptation” after SBR. Importantly, huge differences in the mRNA expression of genes related to intestinal lipid absorption were observed between the remnant jejunum and ileum, and above differences were only slight changed after SBR on both POD7 and POD14.
Conclusions
Insufficient compensation of the gene expression related to intestinal lipid absorption might be the cause of prolonged lipid malabsorption after SBR.
Inclusion of social values, priorities, and motivations for mangrove conservation in Bhitarkanika, India
Authors: Rasquinha Dina , Mukherjee Nibedita , Mishra Deepak
Published: December 2022

The discourse on mangrove conservation has typically used the ecosystem services narrative– nature as the service provider, to develop management regimes across the globe. In contrast, the emphasis on the reciprocal nature of human relationships with these forests, that is, how local human communities relate with, perceive, and maintain these seascapes, has received little attention. This study distinguishes the value-preference paradigm in a protected mangrove forest region, Bhitarkanika Wildlife Sanctuary, on the east coast of India. We ask how exclusion impacts local values, motivations, and priorities towards mangrove forest conservation. Using the Q-methodology, a mixed method approach, we identify the narratives that dominate the human-mangrove reciprocal sphere. Our findings reveal three distinct narratives: livelihood security that calls for both current and perceived focus on quality-of-life attributes in the region closely related to the livelihoods of the local people, conservation value through management which drives the management regime of this region, and sense of place that reinforces the importance of recognizing social and cultural norms. These narratives are also influenced by gender, accentuating the need for more gender sensitive approaches in value-preference literature and conservation policies. A value-centered approach that looks at how people perceive, value, and prioritize mangrove conservation narratives illuminates the assumptions of conventional neoliberal approaches in identifying differences and similarities in people’s value systems that shape their understanding, interests, and interactions with their environment.