bluuebunny/crossref_metadata_2025 huggingface dataset:
MODEL LEĆE: PROMOCIJA NEUROREZILIENCIJE I ZDRAVLJA MOZGA U STARIJOJ DOBI
Authors: Jakovljevć Miro
Published: September 2021

Poticanje zdravog i uspješnog starenja i uključenosti starijih osoba u društvene aktivnosti, odnosno učinkovita prevencija negativnih posljedica starenja, iznimno je važna ne samo medicinska i humanistička već i socijalna, ekonomska i politička tema. Promjene mozga koje počinju u pedesetim godinama života ne oštećuju samo pamćenje nego i druge kognitivne funkcije, kao što su naša sposobnost obavljanja više radnji, brzo procesiranje informacija i usmjeravanje pažnje na detalje, a smanjuje se i naša kreativnost, kvaliteta življenja, životna energija i želja za životom. Mnogo je pogrešnih stavova i iskrivljenih mišljenja o mozgu i starenju. Gerontologija se sve više usmjerava na prepoznavanje specifičnih kvaliteta i sposobnosti starijih osoba i njihov mogući doprinos zajednici i društvu. Reziliencija predstavlja skup zaštitnih i salutogenih (kako neurobioloških tako i psihosocijalnih i spiritualnih) čimbenika koji moduliraju pozitivne ishode u stresnim i nepovoljnim situacijama, tijekom starenja i u bolesti. Do unazad dva-tri desetljeća vjerovalo se da naš mozak stvara nove neurone samo u ranoj mladosti. Međutim, istraživanja pokazuju da mozak zahvaljujući svojoj neuroplastičnosti ima sposobnost mijenjati se tijekom cijelog života stvaranjem novih neurona i veza između njih pa čak i povećati svoju veličinu. Naše spoznaje o neuroplastičnosti mozga u stalnom su porastu, a povećanje reziliencije našeg mozga veliki je izazov za temeljne i kliničke neuroznanosti. Individualna SSPP (Snaga, Slabost, Prilike, Prijetnje) analiza, koja uključuje jedinstvene resurse i perspektive ljubavi, moći, slobode, sreće i smisla, predstavlja model leće kroz koju se prelamaju izazovi starije životne dobi i predviđa uspješno starenje. U tekstu se prikazuje model leće za uspješno starenje kroz promociju reziliencije.
Kakvo Izborno zakonodavstvo vodi BiH u društvo evropskih naroda?
Authors: Kukić Slavo
Published: September 2021

Koliko god politička demokracija nije idealnotipsko rješenje za ostvarenje principa društvene pravde i jednakosti, na današnjemu stupnju razvoja ona znači najmanje odstupanje od tih principa. Nažalost, unutar nje su mnoga rješenja koja znače, manje ili više očigledan odmak i od onoga što politička demokracija može dosegnuti. Bosanskohercegovačko iskustvo, utemeljeno na Izbornom zakonu iz 2001. godine, u prilog tome najzornije svjedoči. Jer nedorečenosti, koje su u njemu i više nego evidentne, su 20 godina njegova funkcioniranja bile razlogom za nezadovoljstvo gotovo svih aktera u bosanskohercegovačkoj političkoj areni. Stoga se od prvog dana njegova života mogu pratiti i kritike na veliki dio, u njemu ugrađenih rješenja pri čemu se i zakon nerijetko optužuje kao uzrok individualne i kolektivne neravnopravnosti bosanskohercegovačkih građana i naroda, ali i zahtjevi da se zakon mijenja kako bi se eliminirali uzroci nejednakosti, neravnopravnosti, disfunkcionalnosti državnih i inih institucija itd. Pitanje je, međutim, koji smjer i pravac promjena u izbornomu zakonodavstvu tim zahtjevima i eliminaciji apostrofiranih uzroka mogu udovoljiti? U ovom radu su ponuđeni neki od principa koji bi na tom tragu mogli biti.
Ideje za reformu Izbornog zakonodavstva
Authors: Pejanović Mirko
Published: September 2021

U referatu „Ideje za reformu izbornog zakonodavstva”, osim uvoda, obrađuju se ovi segmenti: društveno-istorijski uslovi u kojima se u Bosni i Hercegovini 1990. godine formira politički pluralizam na etničkoj osnovi, zatim oblikovanje zakonskog okvira za izborni sistem Bosne i Hercegovine u postdejtonskom razvoju Bosne i Hercegovine. u elaboraciji teme, fokus je dat na ideje za reformu izbornog zakonodavstva. Pokrenute su sljedeće ideje: kako uvesti odredbu o vanrednim izborima, u svim situacijama, kad pobjedničke stranke odlažu više od šest mjeseci implementaciju rezultata parlamentarnih izbora. Pokrenuta je i inicijativa da se podigne izborni cenzus za učešće stranaka u parlamentarnim izborima, tako što bi izborni cenzus umjesto 3% bio 5%. Na ovaj način bi se okrupnjavala politička scena: u izborima bi učestvovao manji broj stranaka. Istovremeno bi pobjedničke stranke dobile veći koalicioni potencijal. Zagovara se i treća ideja za reformu izbornog zakonodavstva: uvođenje tehničkih inovacija u činu glasanja na izbornom mjestu. Uzete u cjelini ideje koje se zagovaraju za reformu izbornog zakonodavstva anuliraju mnoge već pokrenute ideje, koje imaju za cilj da izborni sistem posluži daljoj etnizaciji prostora u Bosni i Hercegovini.
Corporate Financial Performance and Tobin’s Q in Dividend and Growth Investing
Authors: Mysaka Hanna , Derun Ivan
Published: September 2021

Investor attracting and keeping requires both successful management of a company’s financial performance and an investor’s behavior knowledge, as well as monitoring of stock market current trends. This paper contains the study results on the influence of public companies’ financial performance on Tobin’s q as a common measure of investment opportunity for dividend (income) investors and growth investors in conditions of competition and financing limitations. The goal of this article is to identify the financial performance indicators of public companies, influencing their Tobin’s q, for dividend (income) investing and growth investing respectively. We determined that the proxies for the variables of the Tobin’s q function should be different for different investment styles. For this reason, we composed two sets of financial ratios that reflect financial performance specifics of dividend (income) stock companies and growth stock companies for the quantitative assessment of these investor types’ preferences. The analysis results led to the conclusion that a company can attract attention of dividend (income) investors by demonstrating higher levels of dividend payments. Whereas, growth investors are sensitive to the level of company’s business activities, which is related to its revenue. Based on the results of this study, we believe that investment decisions’ successfulness depends on the reliability of the issuer’s financial statements. In our conclusions, we suggest that public companies’ managers focus on the financial performance that best correlate with the preferences of certain type of investors, which is a promising way to attract and keep their investors.
The Use of Accounting Policy Options under IFRS in Europe: Do Country, Industry, and Topic Factors Matter?
Authors: Eisenschmidt Karsten , Krasodomska Joanna
Published: September 2021

Since the formation of the International Accounting Standards Board (IASB), the use of In-ternational Financial Reporting Standards (IFRS) has spread and they have become global standards for financial reporting. However, they are not used unanimously all over the world. This paper focuses on differences in countries’ approaches to IFRS. Our study aims to investi-gate the use of accounting policy choice for selected options in Europe with a particular focus on countries, industry and topic-specific firm factors. We analyze financial statements of 416 companies of the STOXX Europe 600 operating in 17 European countries. We use content analysis to identify the companies’ decisions to choose a particular option allowed under IFRS and run a logistic regression to identify potential factors that influence them. Our findings suggest that the factors under investigation do not always have a significant influence on the accounting option choice. However, the country variables seem to have a stronger influence than industry or topic variables. The study contributes to the body of literature mainly because it investigates a uniform European setting with the use of the 2017 data and it covers coun-tries not included in previous studies. Its results also provide a basis for discussion on the fi-nancial statements quality and the impact of IFRS across countries.
Proposta de Algoritmo por Crescimento Gradativo de Diâmetro para Detecção de k-Flocks em Dados de Trajetórias
Authors: Almeida Luan V. de , Verdade Vinicius E. C. , Kaster Daniel S.
Published: September 2021

Há uma demanda crescente por dispositivos para coletar e analisar informações relacionadas à geolocalização, incluindo a descoberta de padrões de comovimento de objetos móveis. Entre os padrões de comovimento mais relevantes está o padrão Flock. Um flock é um conjunto de objetos que se movem juntos, definidos por um disco móvel de diâmetro fixo, por um período consecutivo de instantes de tempo. Recentemente, foi proposta uma variação desse padrão, denominada padrão kϵ-Flocks, que dispensa a definição do parâmetro distância. O algoritmo existente para detectar kϵ-Flocks segue uma abordagem top-down, começando por umúnico flock candidato e realizando subdivisões sucessivas até encontrar k flocks com o menor diâmetro possível. Este trabalho propõe um novo algoritmo bottom-up para o problema kϵ-Flocks, baseado no agrupamento iterativo de elementos próximos no espaço até detectar os kϵ-Flocks. O trabalho descreve os fundamentos da solução, discute sua correção e apresenta o algoritmo proposto. Espera-se que o algoritmo proposto seja mais eficiente que o algoritmo top-down em muitos casos típicos.
Avaliação da Acessibilidade de Regiões Urbanas de Curitiba aos Serviços de Saúde Pública Baseada em Análise de Grafos e Georreferenciamento
Authors: Lima Clauciane , Peixoto Altieris M. , Gomes-Jr Luiz , Fonseca Keiko V. O. , Lüders Ricardo
Published: September 2021

Este artigo descreve uma abordagem baseada em análise de grafos e georreferenciamento para determinar medidas de acessibilidade de regiões urbanas às unidades de saúde, utilizando dados abertos de serviços de saúde e transporte públicos de Curitiba. Um bom atendimento primário de saúde pode evitar complicações e reduzir consequências das doenças, além de considerar questões sociais de atendimento da população. A acessibilidade foi medida para deslocamentos a pé e por transporte público. Estas medidas são agregadas em um modelo que considera fatores socioeconômicos para listar zonas de maior vulnerabilidade, as quais devem ser priorizadas em termos de investimento público ou ajustes na rede de transporte. Os resultados mostram que o modelo utilizado é efetivo na identificação de regiões vulneráveis.
Modelo de predição de valores de mercado para apartamentos na Barra da Tijuca utilizando Regressão Linear Múltipla
Authors: Gonçalves Marcus Vinicius Ferreira , Xavier Carlos Augusto Gomes
Published: September 2021

A avaliação de imóveis estima o valor de mercado em função de diversos fatores e muitas vezes ocorre de forma subjetiva, complexa e sem uma metodologia definida e de conhecimento público. Este artigo apresenta a aplicação experimental de Ciência de Dados e Aprendizagem Supervisionada para realizar a avaliação de imóveis a partir de dados coletados em um site de compra e venda. O artigo descreve as etapas e resultados e a construção de um modelo de regressão linear múltipla para o contexto elaborado. Após a finalização, o modelo foi testado e apresentou uma boa capacidade preditiva em relação à acurácia do modelo.
Teasy: A domain-specific language to reduce time and facilitate the creation of tests in web applications
Authors: Lima Yury Alencar , Rodrigues Elder de Macedo , Basso Fabio Paulo , Oliveira Rafael A. P.
Published: September 2021

Software testing automation is one of the most challenging activities in Software Engineering scenarios. Moden-Based Testing (MBT) is a feasible strategy to alleviate efforts on automating testing activities. Trough a model that specifies the behavior of the Software Under Testing (SUT), MBT approaches are useful strategies to generate test cases and run them. However, some domains such as, web applications require extra efforts on applying MBT approaches. Due to this, in this study we propose and validate Teasy a Domain Specification Language (DSL) that makes MBT feasible for web application. Through the conduction of a Proof-of-Concept on testing a real-world web application, we noticed Teasy has potential to evolve to effectively support software development environments. Using a real-world application and projects with manually seeded faults, Teasy testing scenarios have detected 78,57% of the functional inconsistencies.
A Look at the Industrial Production of Olefins Based on Naphtha Feed: A Process Study of a Petrochemical Unit
Authors: Davarnejad Reza , Azizi Jamal , Bahari Shaghayegh
Published: September 2021

Olefins (ethylene, propylene and butadiene) as raw materials play an important role in a lot of chemical and polymer products. In industrial scale, there are several techniques from crude oil, natural gas, coal and methanol for the olefins production. Each of these has some advantages. The petrochemicals with liquid feed can simultaneously produce all of the olefins. Shazand Petrochemical Co. (as the first olefins production unit in Iran) produces all of the olefins using naphtha (light and heavy) feed. In this chapter, the production process of olefins based on naphtha will be studied from the beginning to the end (involving pyrolysis, compression, chilling and fractionation processes).
Housing and Rabbit Welfare in Breeding Does
Authors: Villagrá García Arantxa
Published: September 2021

Animal welfare is a rising concern in livestock production and to assess the welfare state of an animal, it is needed to consider health, behaviour and emotions. Housing conditions and management normally impair animal welfare at different levels, so developing housing systems and management practices that imply a high level of animal welfare by preserving productive results is a need. Rabbit cages have to be improved in terms of space, enrichment and materials used to promote better conditions, and several alternatives are under evaluation such as increasing available space, providing animals with elevated platforms and hiding spaces, making available gnawing materials or changing cage materials. Moving from individual to collective housing systems to enhance social interaction is also being tested. Most of these alternatives have provided some steps towards better housing and management conditions for rabbits, while some of them have demonstrated to create more problems and have been abandoned. There is still a long way to go on this research topic.
Green Supply Chain in Solid Waste Management: Case Study of EcoCare H2H Waste Collection, Goaso, Ghana
Authors: Nyarko Jackson , A. Yeboah Frank , A. Yeboah Felix , S. Larbi Isaac , Osei-Bonsu Maxwell
Published: September 2021

Today, Green supply chain management (GSCM) has become a multidisciplinary concept by constructing environmental management practices in the context of various supply chains including waste management services. Environmental issues have become an important integration into the supply chain management, so that each step from organization’s materials management and transportation functions to the end customer can be structured to include environmental awareness. The authors analyze the levels of application of GSCM in waste management value chain of Ghana and use our house-to-house waste collection model as case. Review of the social, environmental and economic impacts made by waste EcoCare and other solid waste management companies that incorporate circularity – at least a recovery and recycling channel at some point – into their service shows are setting a pace for understanding, adoption and replication of green supply chain management (GSCM) into waste management in the country. The authors recommend that private-public-partnerships for waste management in Goaso and other cities would be greener if they replicated the circular economy model implemented by EcoCare Waste Initiative and its H2H Waste Collection model.
Mechanism for Flexible Solar Cells
Authors: Salman Muhammed Ghaida
Published: September 2021

Flexible photovoltaics are covering the way to low-cost electricity. The build-up of organic, inorganic and organic–inorganic solar cells on flexible substrates by printing technologies is to provide lightweight and economic solar modules that can be incorporated in various surfaces. Progress of flexible and lightweight solar cell is interesting for many terrestrial and space applications that require a very high specific power. Thin-film solar cells on polymer films can produce more than 2KW\\Kg specific power. Flexible solar cells are proposed to open up a numerous of possibilities for enabling new applications in consumer electronics and space satellites. Recent research in thin-film electronics has been concentrated on the replacement of the traditional rigid glass plate substrate with plastic or metallic foils. Organic materials bear the potential to develop a long-term technology that is economically viable for large-scale power generation based on environmentally safe materials with unlimited availability. Organic and organic-inorganic photovoltaics (PVs) (third generation solar cells) continue to attract great attention from the PV community, due to their promising features such as low organic–inorganic cost, flexibility and light weight. In this chapter, many of the possible materials for manufacturing of flexible solar cells are discussed.
Survey of Some Exact and Approximate Analytical Solutions for Heat Transfer in Extended Surfaces
Authors: Joel Moitsheki Raseelo , Luyanda Ndlovu Partner , Pauline Ntsime Basetsana
Published: September 2021

In this chapter we provide the review and a narrative of some obtained results for steady and transient heat transfer though extended surfaces (fins). A particular attention is given to exact and approximate analytical solutions of models describing heat transfer under various conditions, for example, when thermal conductivity and heat transfer are temperature dependent. We also consider fins of different profiles and shapes. The dependence of thermal properties render the considered models nonlinear, and this adds a complication and difficulty to solve these model exactly. However, the nonlinear problems are more realistic and physically sound. The approximate analytical solutions give insight into heat transfer in fins and as such assist in the designs for better efficiencies and effectiveness.
Type 2 Diabetes Mellitus: Cardiovascular Autonomic Neuropathy and Heart Rate Variability
Authors: Ferdousi Sultana , Gyeltshen Phurpa
Published: September 2021

Type 2 Diabetes Mellitus is associated with both macro- and microvascular complications. One among the latter, is cardiovascular autonomic neuropathy (CAN). CAN is attributed to cardiac arrhythmias and sudden death. Underlying pathogenesis of cardiac autonomic neuropathy is chronic hyperglycemia induced oxidative stress causing neuronal necrosis, apoptosis and death, leading to the sympathetic and parasympathetic nerve dysfunction. The balance between sympathetic and parasympathetic nervous system is reflected by heart rate variability (HRV). HRV describes “the variations of both instantaneous heart rate and R-R intervals which in turn reflects the cardiac autonomic nervous control”. HRV measured at rest is a marker of autonomic nerve function status. Thus, HRV test is recommended to diagnose diabetic CAN. Time domain parameters predominantly reflect overall autonomic activity and parasympathetic nervous system (PNS) modulations. Frequency domain parameters either reflect, sympathetic nervous system (SNS) activity, PNS activity, or the balance between the two activities. Nonlinear HRV indices marks PNS influences, SNS influences and sympatho-vagal balance. Almost all these HRV parameters are remarkably reduced in T2DM due to cardiac autonomic dysfunction. HRV is an important simple and noninvasive diagnostic tool to detect CAN.
Land Uses Allocation: The Execution of an Artificial Beach and Its Complementary Infrastructures – Madeira Island – Machico, Portugal
Authors: Lousada Sérgio , Loures Luís , Alexandre Castanho Rui
Published: September 2021

The present study aims to propose the creation of an artificial beach in the municipality of Machico and its complementary infrastructures, located on the south-eastern coast of the Madeira Island (Portugal). Machico’s beach sand consists of a mixture of black volcanic sand and round basalt stones. Usually, it has clear waters and a quiet sea. This beach also has a mooring infrastructure, thus allowing access to the sea. In order to achieve this study’s main goals, it was initially carried out an extensive review and bibliographic research. Subsequently, a sand beach and its shelter groins were simulated and designed to hypothetically promote the retention of the sand and mitigate the tidal effects. In addition to model the beach dynamics, an extensive characterization of the extreme maritime regime was performed. The model was developed based on topographic and hydrographic site surveys and the data using Wave Watch III model at 32.0°N, 17.0°W—obtained from SONEL web page, which gathers new data every 6 hours. Besides, the study also contemplated the analysis of the sea inundation quota for a return period of 100 and 500 years and its development along with the Master Plan of the City of Machico. Furthermore, some final remarks and conclusions will be shown; besides, some future projects should be developed to expand the knowledge of this thematic field.
'Erro de Descartes' ou Erro de um Título?
Authors: Ribeiro Ferreira Maria Luísa ,   Philosophy Documentation Center
Published: September 2021

In this article we summarize the central thesis of A. Damásio in his book Descartes' Error. We appreciate the scientifical interest of this work but we criticize the way some philosophical questions are stated, namely the concept of reason and Descartes’ contribution to the mind - body problem. When Damásio accuses Descartes of being guilty for sustaining a «disimbodied mind», he forgets the works where this philosopher explores the mind-body interaction and his broad concept of thinking as including feeling and will. Therefore, we question the title of this work and the false expectations it can produce on his readers.
Kafka e as Metamorfoses da Leí
Authors: Correia Carlos João ,   Philosophy Documentation Center
Published: September 2021

This essay examines the conflict of interpretations arisen by Kafka’s work, specially by his narrative «The Metamorphosis». It analyses the range and limits of the psychological, sociological, theological and existentialist interpretation of Kafka.
Levinas (1906-1995)
Authors: Beckert Cristina ,   Philosophy Documentation Center
Published: September 2021

This essay evokes the life and philosophical thought of an author who died recently: Emmanuel Levinas. It tries to show the in ternal coherence of his work and to question the link between his condition as a Jew and the role it played in the elaboration of a thought dominated by ethical concerns.
As Metamorfoses da Luz, ou a Retórica da Evidência na Filosofia Cartesiana
Authors: Ribeiro dos Santos Leonel ,   Philosophy Documentation Center
Published: September 2021

Pour beaucoup de commentateurs, la philosophie cartésienne de l’évidence rationnelle repousse la rhétorique et les métaphores hors du champ de la philosophie. En soulignant l'omniprésence des images de la lumière et de la vision dans l'oeuvre du philosophe du cogito et de la mathesis, nous essayons de montrer qu'il y a justement une rhétorique de l'évidence cartésienne et que c'est grâce à cette rhétorique que la philosophie de Descartes déploie toute sa puissance. La dominance du principe d'évidence et d'intuition ne va pas sans conséquences, notamment pour la théorie de la définition, mais aussi pour la pratique de l'argumentation philosophique et pour la conception du rôle de l'analogie et de la métaphore dans la philosophie et dans la science. Tout cela obéit à une économie d'intelligibilité qui s'exhibe comme poétique de la visibilité.
Spinoza y el Poder Constituyente
Authors: Aragüés Juan Manuel ,   Philosophy Documentation Center
Published: September 2021

Le projet de Spinoza d'une philosophie de la joie se développe dès une position hipersubjectiviste, presque hobbesienne, laquelle aboutirait à une contraposition entre les subjectivités, vers une autre position dont les traits collectifs sont remarquables. Cette dernière ouvre la porte à une théorie démocratique radicale, munie de tout un batiment épistémologique et ontologique. On peut trouver, dans notre siècle, une autre philosophie, celle de J.-P. Sartre, qui a parcouru un chemin très prochain et qui présente des problèmes politiques parallèles à ceux de la théorie spinozienne, en concret en ce qui concerne la question de la liberté. Le présent article veut penser les limites de la conception spinozienne et sartrienne de la liberté et la dimension politique de la question.
A Natureza da Ideia Platónica
Authors: Mesquita António Pedro ,   Philosophy Documentation Center
Published: September 2021

The deep relationship between the Phaedo and the Parmenides has long been recognised. However, this relationship is usually seen from the point of view of the alleged criticism in Plato's Parmenides of the theory of ideas contained in the Phaedo and in the dialogues which are doctrinally akin to it. For this reason, the thesis argued for in this article is a much rarer one: namely, that the Parmenides represents, within the unity of Plato's thought, the single moment in which the theory of ideas proposed in the Phaedo is radically demonstrated and the notion of 'idea' becomes fully clarified. The objective of this paper is to investigate both dialogues from the point of view of the notion of 'idea' that they implicitly propound, taking into consideration two crucial passages of the Phaedo and the Parmenides whose significance, although frequently ignored, permits overall such a notion to be established. Through this commentary it will then be possible to attain, as its final goal, an enlightening understanding of the nature of platonic 'idea'. But another consequence follows from it: the preclusion of the common, yet particularly misleading, translation of είδος by "Form".
A Identidade de Vénus ou as Vantagens da Extensionalidade
Authors: d'Orey Carmo ,   Philosophy Documentation Center
Published: September 2021

It is generally admitted that extensional semantics are more rigorous than intentional ones and these are more sensitive. Under this point of view, some contexts such as the metaphorical and the fictional, which are central to Aesthetics, are frequently held to be intentional. But difficulties arise out of the seemingly irreducible unclarity of intentional notions such as "meaning", "sense", "intention" and "essence". This paper seeks to show that Goodman's theory allows the explanation of all the subtilities of Aesthetics within a fully extensional semantics. My strategy is to suggest, following Goodman, that "reference" is wider than is commonly recognized and that many of the functions a tribuited to intentional notions are functions of different modes of reference. The advantage is double: an elegant solution for ancient logical problems and an advancement of the cognitive conception of art.
A Obra como Facto Comunicativo
Authors: Rodrigues Manuel J. ,   Philosophy Documentation Center
Published: September 2021

Cet essai se présente comme une réflexion sur le processus historique de génération et de gestion des re ssources artistiques (et culturelles), dans une perspective centrée dans l'activité communicative. Visée comme facteur de communication résistant aux usures de l'acte communicatif, elle est interprétée comme un trafic de sens canalisé par des intêrets sociaux mais culturellement mobilisée par un intêret excentrique. Produisant l'estime, l'oeuvre d'art, se présente comme une antécipation d'avenir, réussie dans la reconnaissance de la valeur de la présence et dans l'éxigence de "meilleur" par rapport au mode de faire; ainsi, elle manifeste une intentionalité transsistémique qui prépare la sensibilité à sa supération en humanité et dessine un temps à venir qui refuse les idéaux directeurs, terminaux ou provisoires.
'Ideia Poética' e 'Ideia Filosófica'. Sobre a Relação entre Poesia e Filosofia na Obra de Antero de Quental
Authors: Ribeiro dos Santos Leonel ,   Philosophy Documentation Center
Published: September 2021

Une relecture des idées de Antero de Quental concernant la nature de la poésie et de la philosophie nous montre que l'hybridisme de l'oeuvre du poète-philosophe portugais est solidaire d’une cohérente et suffisament dessinée conception de la poétique de l'esprit, laquelle, d'ailleurs, a été partagée par d'autres représentants de la culture poétique et philosophique du XIXe siècle. Le cas Antero illustre la condition de la pensée et de la littérature depuis le Romantisme, caractérisée par la crise des genres philosophique et poétique, par le changement du statut même de l'acte philosophique, et par la reconnaissance de l'originaire affinité et voisinage entre le philosophe et le poète.
O Outro Literário
Authors: Becker Cristina ,   Philosophy Documentation Center
Published: September 2021

This paper tries to show how E. Levin as thinks literature as an expression of the Other. After having criticised the nature of modern art in general as purely ontological and neutral, he intends to recover the ethical transcendence of the Other present in the poetic word. To accomplish this task he searches inspiration on the works of Proust, Leiris and, most of all, on Blanchot's notion of an "endless writing”.
Economia e Política em Hume
Authors: Alexandre António Franco ,   Philosophy Documentation Center
Published: September 2021

This paper is part of an on-going study of Hume's place in the genesis of liberal political thought. An analysis of his so-called "economic" essays makes use of Adam Smith’s construction of "mercantilism" to pinpoint Hume's new conceptualisation of work, consumption ("luxury") and culture, as main categories in the analysis of modern "commercial society" in its opposition to ancient "republican" concepts of moral and political life. An attempt is made to relate Hume's new concept of individuality with the main thrust of his epistemology and metaphysics.
SOURCE-PANC: A Prediction Model for Patients With Metastatic Pancreatic Ductal Adenocarcinoma Based on Nationwide Population-Based Data
Authors: van den Boorn Héctor G. , Dijksterhuis Willemieke P.M. , van der Geest Lydia G.M. , de Vos-Geelen Judith , Besselink Marc G. , Wilmink Johanna W. , van Oijen Martijn G.H. , van Laarhoven Hanneke W.M.
Published: September 2021

Background:A prediction model for overall survival (OS) in metastatic pancreatic ductal adenocarcinoma (PDAC) including patient and treatment characteristics is currently not available, but it could be valuable for supporting clinicians in patient communication about expectations and prognosis. We aimed to develop a prediction model for OS in metastatic PDAC, called SOURCE-PANC, based on nationwide population-based data.Materials and Methods:Data on patients diagnosed with synchronous metastatic PDAC in 2015 through 2018 were retrieved from the Netherlands Cancer Registry. A multivariate Cox regression model was created to predict OS for various treatment strategies. Available patient, tumor, and treatment characteristics were used to compose the model. Treatment strategies were categorized as systemic treatment (subdivided into FOLFIRINOX, gemcitabine/nab-paclitaxel, and gemcitabine monotherapy), biliary drainage, and best supportive care only. Validation was performed according to a temporal internal–external cross-validation scheme. The predictive quality was assessed with the C-index and calibration.Results:Data for 4,739 patients were included in the model. Sixteen predictors were included: age, sex, performance status, laboratory values (albumin, bilirubin, CA19-9, lactate dehydrogenase), clinical tumor and nodal stage, tumor sublocation, presence of distant lymph node metastases, liver or peritoneal metastases, number of metastatic sites, and treatment strategy. The model demonstrated a C-index of 0.72 in the internal–external cross-validation and showed good calibration, with the intercept and slope 95% confidence intervals including the ideal values of 0 and 1, respectively.Conclusions:A population-based prediction model for OS was developed for patients with metastatic PDAC and showed good performance. The predictors that were included in the model comprised both baseline patient and tumor characteristics and type of treatment. SOURCE-PANC will be incorporated in an electronic decision support tool to support shared decision-making in clinical practice.
Réévaluation des propriétés psychométriques et d’invariance des items contribuant à la version française de l’échelle Strength of Motivation for Medical Studies (SMMS)
Authors: Béthys Aurélien , Lebon Quentin , Nourisson Clarisse , Peneau Julia , Phelippeau Mona , Pineau Valentin , Guihard Gilles
Published: September 2021

L’Échelle de mesure de la force de motivation pour les études médicales (version française de Strength of Motivation for Medical Studies [SMMS]) comporte 16 items et sa version abrégée, 15 items (SMMS-R). Elles ont toutes deux fait l’objet d’analyses structurales aux Pays-Bas et en France. Toutefois, ces précédents travaux présentaient plusieurs fragilités méthodologiques. Menée auprès de 410 étudiants de seconde et troisième années de formation médicale, cette étude, appuyée sur une méthodologie rigoureuse, concerne les propriétés structurales de l’échelle, une mesure d’invariance et la recherche de différences liées au genre. Une matrice de corrélation polychorique a été exploitée pour des analyses factorielles exploratoires et confirmatoires en utilisant comme estimateur la méthode des moindres carrés pondérés avec un ajustement sur la moyenne et la variance. La mesure d’invariance a été conduite par une analyse factorielle confirmatoire multigroupe. Les différences liées au genre ont été explorées statistiquement. Les résultats valident un nouveau modèle structural à trois facteurs (acceptation de sacrifices, opiniâtreté, capacité d’engagement) pour la version française de l’échelle. La mesure d’invariance montre que l’interaction item/facteur n’est pas influencée par le genre. Enfin, l’analyse révèle que la force de motivation est pareillement exprimée par les étudiantes et les étudiants.
Negrura, brancura e mestiçagem no imaginário literário brasileiro
Authors: Inkpin Sally Cheryl
Published: September 2021

O objetivo central deste livro é analisar como as ideologias da brancura, negrura e mestiçagem foram criadas e se inseriram no imaginário literário brasileiro, apoiando uma hegemonia sociocultural que enaltece a beleza, os valores e a cultura forjados como sendo do branco em detrimento aos padrões e valores das populações indígena e negra.
Microbial growth in biobeds for treatment of residual pesticide in banana plantations
Authors: Domínguez-Rodríguez Verónica I. , Baltierra-Trejo Eduardo , Gómez-Cruz Rodolfo , Adams Randy H.
Published: September 2021

Background

High doses of ethylenebisdithiocarbamate (EBDC) are used in banana production, and unused pesticide mixture (solution) is often disposed of improperly. This can result in soil and water contamination and present an undue risk to rural communities and the environment. An alternative to reduce the environmental impacts caused by pesticide residues is the biobeds treatment. It is necessary to establish if the composition of the proposed biomixtures supports microbial activity to degrade pesticides in biobeds. This research aimed to evaluate the EBDC effect on the distribution and abundance of microbial populations in polluted biomixtures .

Methods

For this purpose, a biomixture based on banana stem, mulch, and Fluvisol soil (50:25:25% v/v) was prepared and polluted with 1,000 mg L−1 EBDC. The response variables kinetics were determined every 14 days for three months, such as pH, organic matter, moisture, cation exchange capacity, microbial colonies, and cell counts at three depths within the experimental units.

Results

EBDC reduced the number of microbial colonies by 72%. Bacterial cells rapidly decreased by 69% and fungi 89% on the surface, while the decrease was gradual and steady at the middle and bottom of the biobed. The microbial populations stabilized at day 42, and the bacteria showed a total recovery on day 84, but the fungi slightly less. At the end of the experiment, the concentration of EBDC in the biomixture was 1.3–4.1 mg L−1. A correlation was found between fungal count (colonies and cells) with EBDC concentration. A replacement of the biomixture is suggested if the bacterial population becomes less than 40 × 106 CFU mL−1 and the fungal population less than 8 × 104 CFU mL−1 or if the direct cell count becomes lower than 50 × 104 cells mL−1 in bacteria and 8 × 102 cells mL−1 in fungi.

Conclusion

The biomixture based on banana stem supports the microbial activity necessary for the degradation of the EBDC pesticide. It was found that fungi could be used as indicators of the pollutant degradation process in the biomixtures. Microbial counts were useful to establish the mobility and degradation time of the pesticide and the effectiveness of the biomixture. Based on the results, it is appropriate to include the quantification of microbial populations to assess the effectiveness of pesticide degradation and the maturity level of the biomixture.
DIREITO À IDENTIDADE GÊNERO NO USO BANHEIROS CONFORME AUTOIDENTIFICAÇÃO: A INCONSTITUCIONALIDADE DA LEI Nº 3878, DE 04 DE SETEMBRO DE 2018, DO MUNICÍPIO DE FEIRA DE SANTANA-BA
Authors: Costa Brenda Capinã Botelho
Published: September 2021

Neste trabalho analisamos a constitucionalidade de Lei municipal nº 3878/2018, de Feira de Santana, Bahia. A norma em comento proíbe que pessoas trans utilizem banheiros, vestiários e espaços segregados por gênero conforme autoidentificação. Com base em pesquisa na jurisprudência do Supremo Tribunal Federal, evidenciamos a existência de um direito à identidade de gênero no ordenamento jurídico brasileiro, que encontra amparo em normas constitucionais, nos direitos da personalidade e no princípio da dignidade da pessoa humana. Ao final, concluímos que a lei feirense é materialmente e formalmente inconstitucional frente à Constituição do Estado da Bahia e à Constituição Federal.
RESPEITO, PROMOÇÃO E PROTEÇÃO DOS DIREITOS DAS PESSOAS LGBTQIAP+ NAS RELAÇÕES DE TRABALHO
Authors: De Oliveira Renata Moura Miranda
Published: September 2021

O artigo tem como objetivo principal analisar a realidade de discriminação, desrespeito, negação e sistemática violação de direitos humanos por que passam as pessoas LGBTQIAP+, nas mais diversas relações sociais, os reflexos dessa realidade na empregabilidade dessas pessoas, a responsabilidade social e jurídica das empresas com a garantia de condições justas e favoráveis de trabalho a essa minoria e o papel fundamental do Ministério Público do Trabalho na promoção da igualdade de oportunidades e no combate à discriminação no trabalho em face das pessoas LGBTQIAP+.
A RELATIVIZAÇÃO DO REQUISITO DA PUBLICIDADE NAS UNIÕES ESTÁVEIS HOMOAFETIVAS: Proteção do direito à privacidade nas relações afetivas de pessoas não-heterossexuais na ordem jurídica brasileira.
Authors: Silva Lucas Bittencourt , Freitas Victória Costa
Published: September 2021

O objetivo deste artigo é investigar a possibilidade de relativizar o requisito da publicidade nas uniões estáveis homoafetivas quando um ou ambos os companheiros não tenham a sua orientação sexual assumida perante a sociedade, tendo em vista a homofobia enquanto realidade fática e o direito à privacidade. Dessa forma, analisa-se se as regras pertinentes à união estável heteroafetiva podem ou não ser totalmente aplicadas por analogia, tendo em vista as peculiaridades das relações homoafetivas, o que remete ao exercício do direito à privacidade como meio de lidar com a homofobia. Nesse contexto, investiga-se os precedentes do Supremo Tribunal Federal aplicados ao tema, a natureza da união estável na teoria do fato jurídico, a espécie de publicidade exigida como requisito da união estável, a tutela do direito à privacidade, a homofobia como circunstância fática e as decisões sobre a relativização do requisito da publicidade. Para tanto, utiliza-se a pesquisa básica e exploratória e aplica-se o método dedutivo, bem como a metodologia de pesquisa bibliográfica e documental de jurisprudência. Como resultados principais: aplicam-se os precedentes da ADPF 132 e da ADI 4.277 do STF às uniões estáveis homoafetivas; enquadra-se a união estável como ato-fato jurídico; elege-se a publicidade-cognoscibilidade como a exigida como requisito da união estável; engloba-se a tutela da orientação sexual na vida privada, a qual se insere no direito à privacidade; confirma-se a homofobia como circunstância fática peculiar às uniões homoafetivas; e encontra-se precedentes recentes favoráveis à mitigação. Por fim, conclui-se que é possível relativizar o requisito da publicidade.
OS DIREITOS E GARANTIAS DOS REFUGIADOS LGBTS NA ATUALIDADE
Authors: Calissi Jamile Gonçalves , De Castro Cristina Veloso , De Oliveira Edmundo Alves
Published: September 2021

O presente artigo diz respeito aos refugiados LGBTs na contemporaneidade e em nível global. Respostas para as perguntas de quem são eles, quais os órgãos de proteção aos mesmos, quais são os direitos e garantias fundamentais oferecidas a essa população e os casos concretos que ilustram o assunto, além de dados e informações que, numérica e concretamente, mostrem a quantidade de pessoas que sobrevivem diante desta situação e circunstâncias, são encontradas na referida pesquisa. O objetivo principal é explanar e informar à comunidade em geral, e, principalmente, à acadêmica, acerca do tema, a fim de dar-lhe conhecimento amplo, já que não é comumente tratado. O estudo possui um caráter qualitativo, em que foram colhidas sobre a matéria em questão tudo o que se precisa saber para entendê-la e formar um alicerce textual, conjuntamente ao uso do método bibliográfico-teórico e o caráter dedutivo, usando-se fontes de pesquisa tanto primária quanto secundária.
PD‐1‐induced T cell exhaustion is controlled by a Drp1‐dependent mechanism
Authors: Simula Luca , Antonucci Ylenia , Scarpelli Giorgia , Cancila Valeria , Colamatteo Alessandra , Manni Simona , De Angelis Biagio , Quintarelli Concetta , Procaccini Claudio , Matarese Giuseppe , Tripodo Claudio , Campello Silvia
Published: September 2021

Programmed cell death‐1 (PD‐1) signaling downregulates the T‐cell response, promoting an exhausted state in tumor‐infiltrating T cells, through mostly unveiled molecular mechanisms. Dynamin‐related protein‐1 (Drp1)‐dependent mitochondrial fission plays a crucial role in sustaining T‐cell motility, proliferation, survival, and glycolytic engagement. Interestingly, such processes are exactly those inhibited by PD‐1 in tumor‐infiltrating T cells. Here, we show that PD‐1pos CD8+ T cells infiltrating an MC38 (murine adenocarcinoma)‐derived murine tumor mass have a downregulated Drp1 activity and more elongated mitochondria compared with PD‐1neg counterparts. Also, PD‐1pos lymphocytic elements infiltrating a human colon cancer rarely express active Drp1. Mechanistically, PD‐1 signaling directly prevents mitochondrial fragmentation following T‐cell stimulation by downregulating Drp1 phosphorylation on Ser616, via regulation of the ERK1/2 and mTOR pathways. In addition, downregulation of Drp1 activity in tumor‐infiltrating PD‐1pos CD8+ T cells seems to be a mechanism exploited by PD‐1 signaling to reduce motility and proliferation of these cells. Overall, our data indicate that the modulation of Drp1 activity in tumor‐infiltrating T cells may become a valuable target to ameliorate the anticancer immune response in future immunotherapy approaches.
Human intestinal and circulating invariant natural killer T cells are cytotoxic against colorectal cancer cells via the perforin–granzyme pathway
Authors: Díaz‐Basabe Angélica , Burrello Claudia , Lattanzi Georgia , Botti Fiorenzo , Carrara Alberto , Cassinotti Elisa , Caprioli Flavio , Facciotti Federica
Published: September 2021

Invariant natural killer T (iNKT) cells are lipid‐specific T lymphocytes endowed with cytotoxic activities and are thus considered important in antitumor immunity. While several studies have demonstrated iNKT cell cytotoxicity against different tumors, very little is known about their cell‐killing activities in human colorectal cancer (CRC). Our aim was to assess whether human iNKT cells are cytotoxic against colon cancer cells and the mechanisms underlying this activity. For this purpose, we generated stable iNKT cell lines from peripheral blood and colon specimens and used NK‐92 and peripheral blood natural killer cells as cell‐mediated cytotoxicity controls. In vitro cytotoxicity was assessed using a panel of well‐characterized human CRC cell lines, and the cellular requirements for iNKT cell cytotoxic functions were evaluated. We demonstrated that both intestinal and circulating iNKT cells were cytotoxic against the entire panel of CRC lines, as well as against freshly isolated patient‐derived colonic epithelial cancer cells. Perforin and/or granzyme inhibition impaired iNKT cell cytotoxicity, whereas T‐cell receptor (TCR) signaling was a less stringent requirement for efficient killing. This study is the first evidence of tissue‐derived iNKT cell cytotoxic activity in humans, as it shows that iNKT cells depend on the perforin–granzyme pathway and both adaptive and innate signal recognition for proper elimination of colon cancer cells.
Stabilization of Zn Metal Anode through Surface Reconstruction of a Cerium‐Based Conversion Film
Authors: Deng Canbin , Xie Xuesong , Han Junwei , Lu Bingan , Liang Shuquan , Zhou Jiang
Published: September 2021

Corrosion and dendritic deposition have been the long‐standing interfacial challenges of Zn anode, resulting in the deterioration of the aqueous zinc‐based batteries. Herein, the surface of Zn metal anode is pioneeringly reconstructed by a cerium‐based conversion film (Zn@CCF) through a chemical conversion method. Faster growth of the film in the vicinity of zinc grain boundaries significantly prevents the substrate from genetic micro‐corrosion that leads to catastrophic damage. The affinity of the film toward zinc facilitates a low nucleation barrier and smooth zinc deposition. Consequently, Zn@CCF enables long‐term lifespan (1200 h) with low polarization (≈60 mV) at 4.4 mA cm−2, which also maintains good capacity retention and excellent cycling stability of Zn@CCF/MnO2 full cells. This facile and effective approach helps suppress Zn dendrite formation and brings forward the significance of surface reconstruction of the Zn metal anode for corrosion inhibition, which can be potentially applied to other metal anodes in aqueous energy storage systems.
Transition‐Metal Vacancy Manufacturing and Sodium‐Site Doping Enable a High‐Performance Layered Oxide Cathode through Cationic and Anionic Redox Chemistry
Authors: Shen Qiuyu , Liu Yongchang , Zhao Xudong , Jin Junteng , Wang Yao , Li Shengwei , Li Ping , Qu Xuanhui , Jiao Lifang
Published: September 2021

Triggering the anionic redox chemistry in layered oxide cathodes has emerged as a paradigmatic approach to efficaciously boost the energy density of sodium‐ion batteries. However, their practical applications are still plagued by irreversible lattice oxygen release and deleterious structure distortion. Herein, a novel P2‐Na0.76Ca0.05[Ni0.23□0.08Mn0.69]O2 cathode material featuring joint cationic and anionic redox activities, where native vacancies are produced in the transition‐metal (TM) layers and Ca ions are riveted in the Na layers, is developed. Random vacancies in the TM sites induce the emergence of nonbonding O 2p orbitals to activate anionic redox, which is confirmed by systematic electrochemical measurements, ex situ X‐ray photoelectron spectroscopy, in situ X‐ray diffraction, and density functional theory computations. Benefiting from the pinned Ca ions in the Na sites, a robust layered structure with the suppressed P2‐O2 phase transition and enhanced anionic redox reversibility upon charge/discharge is achieved. Therefore, the electrode displays exceptional rate capability (153.9 mA h g−1 at 0.1 C with 74.6 mA h g−1 at 20 C) and improved cycling life (87.1% capacity retention at 0.1 C after 50 cycles). This study provides new opportunities for designing high‐energy‐density and high‐stability layered sodium oxide cathodes by tuning local chemical environments.