bluuebunny/crossref_metadata_2025 huggingface dataset:
Politik Etnik dan Kekeluargaan Sebagai Sumber Perilaku Politik Masyarakat Pedesaan di Barito Selatan
Authors: Hadi Kisno
Published: May 2023

Tulisan ini mendeskripsi tentang perilaku politik yang berwujud sikap politik masyarakat pedesaan di pedalaman Kalimantan Tengah. Tulisan ini diangkat dari hasil penelitian saat Pemilu legislatif 2019 dan Pilkada Kalteng 2020. Penelitian menggunakan metode kualitatif interpretatif, dengan pengumpulan data lapangan melalui pengamatan langsung di mana penulis berada di lapangan saat pelaksanaan Pemilu 2019 dan PILKADA Gubernur Kalteng 2020, wawancaradengan Mantir Adat (tokoh adat), dan analisis data pustaka berupa buku, jurnal dan data KPU Barito Selatan. Penelitian ini mendeskripsi dua hal, Pertama, fenomena afiliasi politik masyarakat pedesaan di Kabupaten Barito Selatan sebagai pengaruh budaya politik masyarakatsuku Dayak yang hidup dan berkembang dalam suasana masyarakat pedesaan-pedalaman; Kedua, fakta perilaku politik masyarakat pedesaan di Kabupaten Barito Selatan dalam politik elektoral Pemilu 2019 dan Pilkada 2020. Temuan penelitian ialah Pertama, tidak terjadi pergeseran afiliasi politik sejak tahun 1950an sampai saat ini, di mana afiliasi politik masyarakat pedesaan tidak beranjak dari afiliasi etnis; Kedua, afiliasi etnis diperankan sebagai penyeimbang kekuatan politik lain dari luar seperti dominasi etnis lain dan sebagai upaya perlindungan sosial mereka kepada kekayaan sumber daya alam di desa; dan Ketiga, sikap politik dipraktikkan dengan cara mereka sendiri yang khas, yakni personal approach (pengenalan personal),ethnicity (etnisitas dan kekeluargaan), dan opennes and honesty (keterbukaan dan kejujuran).
Peran “Sintalitas” dalam Optimalisasi Pemanfaatan Teknologi Pertanian Padi pada Kelompok Tani Sedyo Luhur di Boyolali
Authors: Wibowo Dina Sulistyo , Wahyuni Hermin Indah , Wati Ratih Ineke
Published: May 2023

Latar belakang penelitian adalah terdapat pengadaan alat dan mesin pertanian (alsintan) olehpemerintah, tetapi pemanfaatannya tidak efektif. Pemerintah juga menggelar sosialisasi UPJA, tetapi belum tumbuh di setiap kelompok tani (poktan). Masalah penelitian adalah tentang sintalitas Poktan Sedyo Luhur dalam optimalisasi pemanfaatan mesin tanam bibit padi.Penelitian ini bertujuan untuk menganalisis sintalitas Poktan Sedyo Luhur dalam optimalisasi pemanfaatan mesin tanam bibit padi. Metode yang digunakan adalah deskriptif secara kualitatif. Lokasi penelitian di Poktan Sedyo Luhur yang berlokasi di Desa Dibal Kecamatan Ngemplak Kabupaten Boyolali. Hasil penelitian menunjukkan bahwa Poktan Sedyo Luhur memiliki sintalitas dalam optimalisasi pemanfaatan mesin tanam bibit padi yang ditunjukkan melalui sifat sintalitas, sifat struktur, dan sifat populasinya. Sifat sintalitas ditunjukkan oleh Poktan Sedyo Luhur yang memiliki pengaruh baik bagi individu anggota maupun anggota bagian dari poktan dan poktan menjalin kerja sama dengan berbagai mitra dalam pengoptimalan pemanfaatan mesin tanam bibit padinya, tetapi jalinannya kurang baik dengan dinas pertanian. Sifat struktur poktan ditunjukkan oleh keberadaan seksi alsintan yang mengelola alsintan bertaraf UPJA dengan 75 persen anggota berperan dalam memanfaatkan alsintan tersebut. Poktan Sedyo Luhur juga mengelola mesin tanam bibit padinya yang disertai dengan batasan norma-norma. Sifat populasi poktan ditunjukkan oleh mayoritas anggota memiliki umur di atas 40 tahun dengan pekerjaan lain di luar pertanian. Poktan Sedyo Luhur harus meningkatkan hubungannya dengan dinas pertanian dan juga meregenerasi anggotanya.
The Factors of Rice Farmers’ Poverty in Indonesia: The Perspective of Land Conversion, Land Ownership Area, and Agriculture Technologi
Authors: Widyanto Septian , Subanu Leksono Probo
Published: May 2023

Rice is very important as Indonesia’s main staple. It contributes a lot to the national expenditure where more than 80% of households of every social class consumed rice. There is a high demand level for rice but there is a limited number of farmers. Of 70% of households in rural that work in the agricultural sector, only 50% grow rice, and most of them are poor farmers. Almost 52% of Indonesia’s rice is produced at Java Isle. However, production growth is only 0,7% given the rapidly increasing number of people and land conversion over the past 7 years. Most Indonesian farmers are classified as small farmers has average land ownership of only less than 0.5 hectares, making them can’t innovate and only can fulfil their basic needs without saving for investment. This is made worse by around 35% of farmers don’t own their land. Technology usage also become an issue where 85% of farmers don’t use internet and 45% are not used in using mechanical technology. The purpose of this research is to find the effect of paddy land conversion, land ownership area, and agriculture technology on farmer’s poverty in Indonesia. By using multiple regression method on 6 independent variables data from all Indonesia provinces, we found that the most significant variable to reduce farmer’s poverty is land ownership area. The statistical result is supported and cross-checked by data and related policies from literature review, and interview with some stakeholders from Ministry of Agriculture, local government, paddy farmer representative, and agriculture instructor.
The Impact of Colonialism in Hugh Lofting’s The Story of Doctor Dolittle
Authors: Medicio Raden Alexander Carlson , Saktiningrum Nur
Published: May 2023

The Story of Doctor Dolittle is the first entry in the Doctor Dolittle series, a children’s book series by English author Hugh Lofting. Despite being primarily aimed at children, the series contains mature themes that help it attract the attention of adults. In particular, The Story of Doctor Dolittle contains themes of colonialism that are drawn from the author’s own experiences. This research aims to discover how colonialism in The Story of Doctor Dolittle has impacted the numerous characters found in it. The original 1920 publication of the book was used as the primary data source, in which it was analyzed using a thorough closed reading of its contents, which is then compared with real-life colonial events. Jurgen Osterhammel’s theory of colonialism is used as the primary theory for this research, which details the processes and results of colonialism on both the colonizers and the colonized, as well as the different types of colonies created to serve different purposes for the colonizers. The results have shown that there are multiple instances of colonialism in The Story of Doctor Dolittle, both positive and negative, that have impacted its characters to varying degrees. Characters such as Doctor Dolittle and the monkeys of the Land of the Monkeys benefited from colonialism due to the former’s altruistic motives, while others like the Jolliginki tribe suffered due to reckless exploitation by the unnamed White Man.
A potential of Jasminum sambac (L.) Aiton leaf nano-extract as spray treatment of gingivitis-induced Sprague Dawley rats
Authors: Nuryanti Archadian , Larasati Puspa Ayu Aprilia , Almeyda Alda Risma , Marandof Monica Agnesia , Irawan Catherine Marcia
Published: May 2023

Gingivitis is the second most common disease that occurs in the oral cavity. The use of chlorhexidine as a gingivitis therapy agent has some side effects such as allergic reactions and bacterial resistance. Jasminum Sambac (L.) Aiton leaf nano-extract contains flavonoids, saponins, and tannins compounds reported to have an influence on wound healing process. The aim of this research was to determine the effect of observation time and concentrations of Jasminum sambac (L.) Aiton leaf nano-extract on the number of neutrophils, macrophages, and angiogenesis in the treatment of gingivitis-induced Sprague Dawley rats. Sixty male Sprague Dawley rats aged 2.5-3 months with body weight of 200-250 g were anesthetized with ketamine HCl (10 mg/kg BW) and xylazine (2 mg/kg BW) then induced using silk ligature 3.0 on the interdental of the mandibular incisor. The rats were divided into five groups and got daily spray using distilled water (negative control), nano-extract at a concentration of 40%, 45%, 50%, and 0.12% chlorhexidine (positive control). The rats were euthanized on the 1st, 3rd, 5th, and 7th days post-treatment. The tissues were processed histologically with HE staining. The number of neutrophils, macrophages, and angiogenesis were counted using a microscope (400x) and OptiLab Viewer® (13x) at five fields of view. The result of the Two Way ANOVA test showed that there were significant effect of concentrations and observation time, and interaction of both observation time and concentrations on the number of neutrophils, macrophages, and angiogenesis (p < 0.05). It can be concluded that observation time and concentrations of Jasminum sambac (L.) Aiton leaf nano-extract affected the number of neutrophils, macrophage, and angiogenesis in the treatment of gingivitis-induced Sprague Dawley rat (p < 0.05).
Prevalence and identification of oral candida species in patients with type 2 diabetes in Yogyakarta
Authors: Agustina Dewi , Chrisnawati Regina Titi , Chrismawaty Bernadetta Esti , Wongsohardjono Sri Budiarti , Naritasari Fimma , Sarasati Andari
Published: May 2023

Patients with diabetes are prone to recurring and even resistant Candidiasis, making treatment challenging. Many hypotheses proposed related to susceptibility of diabetic patients to Candida. The prevalence and species of Candida in a particular diabetic community might be different compared to other diabetic community. This study aimed to determine the prevalence of Candida colony and its species in the oral cavity of diabetic patients included in the CDM (Chronic Disease Management) program in Yogyakarta. One hundred patients with type 2 diabetes (n= 100) were recruited as the subjects of this study. The subjects were classified into controlled and uncontrolled Diabetes mellitus (DM). Samples of oral rinse solution were collected to determine the species of Candida and number of Candida colonies using CHROMagar Candida medium. There were 47 and 53 of subjects with controlled and uncontrolled DM, respectively. The mean number of Candida colony in the subjects with controlled diabetes (1003.13) was higher than that in the subjects with uncontrolled diabetes (478.43). The Candida colony most commonly identified in the subjects with controlled and uncontrolled diabetes were C. albicans and C. glabrata, respectively. Female patients had higher mean number of Candida colony (859.51) compared to male (299.21). The Candida colony most often identified in both genders was C. albicans. In addition, the subjects of this study consisted of 83 geriatric subjects and 17 non geriatric subjects, in which the mean number of Candida colony in the geriatric subjects (761.77) was higher than that in the non-geriatric subjects (545.71). The Candida colony most often identified in the geriatric subjects and non-geriatric subjects was C. albicans and C. glabrata, respectively. The Mann Whitney test demonstrated that there was a significant difference (p = 0.009) of the mean number of Candida colony between male and female. However, there was no significant difference of the mean number of Candida colony between ages (p = 0.060) and diabetic status (p=0.175). It can be concluded that the Candida species most commonly identified in all the subjects was Candida albicans with the mean colony number of 349.96, followed by C. glabrata (225.97), C. krusei (144.91), C. tropicalis (3.67), and other species (2.02).
Relationship between peatland water use and periodontal disease in Daha Selatan Subdistrict
Authors: Hidayah Antung Nurul , Oktiani Beta Widya , Azizah Aulia
Published: May 2023

Periodontal disease is one of the dental and oral health problems in Hulu Sungai Selatan Regency with a prevalence of gingivitis of 24.58% and periodontitis of 10.83%. One of the risk factors for periodontal disease is the use of peatland water. Peatland water has a low pH which can affect the colony of anaerobic bacteria in the oral cavity of the water users. Bacteria that cause periodontal disease are able to develop and survive in acidic conditions. This study aimed to analyze the relationship between peatland water use and periodontal disease in Daha SelatanSubdistrict. This was analytical research with a cross-sectional approach. The sampling technique used a simple random sampling technique with a total sample of 100 people (n = 100) who were residents aged 35-44 years in Daha Selatan Subdistrict. The results showed that the participants with high use of peatland water showedthe highest percentage (39%). In addition, there were 61% respondents who suffered from periodontal disease. ChiSquare test obtained a significance value of 0.022 (p < 0.05), showing that there was a relationship between peatland water use and periodontal disease. The risk of periodontal disease in the respondents who used peatland water in the high category was 4.167 times greater than in the respondents who did not use peatland water. It is essential to educate the general public about the effects that using peatland water can have on dental and oral health because there is a high prevalence of periodontal disease, which is caused by the widespread use of peatland water.
An Inhibition effect of immersion in effervescent garlic ethanol extract (Allium sativum L.) against Staphylococcus aureus growth on heat cured acrylic
Authors: Ramadhanti Dian Praba , Rachmani Eka Prasasti Nur , Kurniawan Aris Aji
Published: May 2023

Denture stomatitis is an infection of the mucosa caused by bacteria such as Staphylococcus aureus (S. aureus) accumulating on the denture. Garlic (Allium sativum) contains antibacterial compounds that can be used as an alternative denture cleanser. The purpose of this study was to determine the inhibition effect of immersion in effervescent garlic ethanol extract (Allium sativum) against Staphylococcus aureus growth on heat cured acrylic dental plate. This research was a laboratory experiment in vitro using 40%, 50%, and 60% effervescent garlic ethanol extract. The samples were 12 pieces (n = 12) of heat cured acrylic plates which were divided into 3 treatment groups then incubated in S. aureus suspension for 24 hours and then immersed in an effervescent garlic ethanol extract for 6 hours. Bacterial colonies were counted using a colony counter and the data were analyzed using the One-way ANOVA and LSD Post hoc tests. The statistical analysis showed that the number of S. aureus colonies decreased along with an increased concentration of garlic ethanol extract. The results of the analysis showed that the 60% effervescent garlic ethanol extract had a significantly lower mean number of colonies compared to the 40% and 50% effervescent garlic ethanol extracts (p ≤ 0.05). This research concluded that effervescent garlic ethanol extract prevented the growth of S. aureus on the heat cured acrylic dental plate.
Differences in injectable platelet-rich fibrin fraction of peripheral blood on the release of TGF-β1 and PDGF-AB
Authors: Suryono Suryono , Danastri Arifia Anindita
Published: May 2023

Injectable platelet-rich fibrin (i-PRF) refers to second-generation platelet concentrate. In this study, the results of i-PRF centrifugation were fractionated into three layers: yellow i-PRF, buffy coat, and red i-PRF. Injectable platelet-rich fibrin fractions used in this study were yellow i-PRF, red i-PRF, and a mix of both. This study aimed to examine the level of growth factor release of transforming growth factor beta 1 (TGF-β1) and platelet-derived growth factor (PDGF) in yellow i-PRF, red i-PRF, and a mix of yellow i-PRF and red i-PRF with the ratio of 1:1. A total of 10 ml of peripheral blood from healthy female donors was centrifuged (at 700 rpm in 3 minutes) to obtain i-PRF and fractionated into three layers. The upper yellow layer was taken as yellow i-PRF, while the bottom red layer was taken as red i-PRF and was taken together with the middle layer (buffy coat). The release of TGF-β1 and PDGF in each of i-PRF fractionation method, i.e. yellow i-PRF, red i-PRF, and a mix of yellow i-PRF and red i-PRF with a ratio of 1:1 was measured with ELISA. The measurement was observed for 24 hours, 3 days, 7 days, 10 days, and 14 days. Data analysis used the two-way ANOVA test with a significance level of 0.05 and a post hoc LSD analysis to establish group significance. The group of yellow + red i-PRF significantly released PDGF-AB (p < 0.05). TGF-β1 was the highest of all groups on day 14. All groups showed an increase in growth factor release from time to time. The fractionation method of injectable platelet-rich fibrin affected the release of growth factor of PDGF-AB and TGF-β1. The highest release of PDGF-AB and TGF-β1 was found in the yellow + red i-PRF group with a ratio of 1:1 in the 14-day group, which was significant with the other two groups (p < 0.05).
Manajemen Perpustakaan Sekolah Menengah Atas Negeri 2 Kabupaten Rejang Lebong
Authors: Rodin Rhoni
Published: May 2023

Tujuan dari penelitian ini adalah untuk menganalisis bagaimana implementasi manajemen pada Perpustakaan SMAN 2 Rejang Lebong. Penelitian ini bersifat deskriptif kualitatif, sedangkan data dikumpulkan dengan tehnik wawancara dan dokumentasi. Teknik analisa data penelitian ini bersifat deskriptif kualitatif yaitu penyajian data dalam bentuk tulisan untuk menerangkan apa yang telah diperoleh dari hasil penelitian kemudian dilakukan analisis secara sistematik. Hasil penelitian menunjukkan bahwa penerapan fungsi manajemen perpustakaan SMAN 2 Rejang Lebong sudah dikelola dengan baik, perencanaannya terstruktur dimuat dalam program kerja baik dalam jangka pendek dan juga jangka panjang. Organisasinya sudah terdapat struktur organisasi dan pembagian tugas dalam pelaksanaan layanan Perpustakaan SMAN 2 Rejang Lebong. Selanjutnya fungsi pengawasan, perpustakaan selalu dibina oleh kepala sekolah. Namun demikian perpustakaan ini belum memiliki laporan tahunan sebagai pertanggungjawaban pengelolaan perpustakaan.
Peta Tematik Penelitian Bidang Layanan Perpustakaan Universitas Pada Masa Pandemi COVID-19
Authors: Adi Nugroho Prasetyo
Published: May 2023

COVID-19 membatasi pergerakan masyarakat. Indonesia yang mempunyai penduduk sebanyak 270 juta jiwa lebih disaat pandemi berlangsung tentunya menerapkan protokol kesehatan dan larangan untuk berkumpul ditempat umum, agar kasus positif COVID-19 serta kematian yang ditimbulkan bisa menurun angkanya. Para akademisi memerlukan banyak referensi untuk acuan dalam mengembangkan kegiatan riset mereka. Perpustakaan digital bisa menjadi salah satu jalur untuk memberikan pelayanan bagi sivitas akademika. Perpustakaan digital memberikan akses ke banyak konten dengan jumlah sumber daya dan pilihan yang tak terbatas. Penelitian ini bertujuan untuk mengobservasi topik, kata kunci yang paling sering digunakan, dan afiliasi author dengan sitasi terbanyak. Penelitian ini mengumpulkan data sekunder dari Scopus.com dengan kata kunci “universitas”, “perpustakaan”, dan “covid”. Data dianalisis dengan menggunakan metode bibliometric. Software yang digunakan untuk menganalisis data yakni Vosviewer dan Biblio Shiny. Hasil penelitian menunjukkan bahwa layanan online, e-learning, internet of things, dan media sosial merupakan strategi yang digunakan perpustakaan secara global untuk mendukung layanan perpustakaan digital selama masa pandemi sesuai dengan kata kunci yang dianalisis.
Penanganan Keluhan Pemustaka Terhadap Layanan Perpustakaan Universitas Gadjah Mada Masa Pandemi COVID-19
Authors: Sayekti Nugroho
Published: May 2023

Pandemi COVID-19 telah membawa perubahan pada eksistensi dan relevansi sumber-sumber pembelajaran yang disediakan oleh perpustakaan perguruan tinggi, termasuk Perpustakaan Universitas Gadjah Mada (Perpustakaan UGM) sebagai pelayanan publik sivitas akademika di UGM. Perpustakaan UGM menerapkan ketentuan-ketentuan baru, model-model pelayanan baru, dan adanya pergeseran paradigma terhadap koleksi yang dilayankan, dari yang sebelumnya berbentuk tercetak menuju ke bentuk elektronik yang dapat diakses secara daring. Perubahan tersebut membawa pengaruh terhadap ketidaksiapan pemustaka dalam memanfaatkan layanan perpustakaan. Akibatnya, pemustaka menjadi tidak puas, tidak senang, tidak nyaman, dan mengeluh atas pelayanan yang diberikan. Tulisan ini menguraikan penanganan keluhan pemustaka terhadap layanan Perpustakaan UGM masa pandemi COVID-19. Berdasarkan uraian tersebut diperoleh gambaran penanganan keluhan pemustaka Perpustakaan UGM, meliputi: 1) media penyampaian keluhan, melalui media sosial, penyampaian secara langsung, dan kolom Aspirasi; 2) jenis keluhan berupa pembatasan waktu kunjungan luring, permintaan karya akhir, dan pemustaka dari luar UGM; 3) solusi atau penanganan keluhan, berupa sosialisasi ketentuan baru layanan Perpustakaan UGM, pemanfaatan aplikasi booking room, perpanjangan jam pelayanan, penambahan kuota pengunjung luring, dan menerima pengunjung luar UGM dan alumni; dan 4) tanggapan dan umpan balik atas solusi yang disampaikan.
Kompetensi Digital Pustakawan dalam Penyelenggaraan Fungsi Layanan Perpustakaan pada Masa New Normal
Authors: Rahmadanita Annisa
Published: May 2023

Tantangan pada masa New Normal menuntut pustakawan untuk inovatif dan adaptif dalam penyelenggaraan fungsi layanan perpustakaan perguruan tinggi. Oleh sebab itu dibutuhkan kompetensi digital dalam rangka mewujudkan fungsi layanan sesuai dengan kebutuhan pemustaka tersebut. Penelitian ini merupakan deksirptif kualitatif. Peneliti melakukan wawancara kepada 10 orang informan yang bekerja pada bidang layanan sirkulasi, layanan referensi, layanan e-resources dan layanan katalog Laporan Akhir dan Skripsi. Analisis data dilakukan melalui teknik reduksi data, penyajian data dan penyimpulan data.  Hasil penelitian menunjukkan bahwa terdapat keterbatasan keterampilan teknis pustakawan terutama dalam penelusuran sumber informasi koleksi buku elektronik dan jurnal elektronik. Terdapat temuan menarik lainnya, bahwa dibutuhkan pustakawan yang memiliki kompetensi digital dalam melakukan pengolahan dan analisis data kepustakawanan dalam rangka mendukung penyelenggaraan fungsi layanan Perpustakaan IPDN pada masa New Normal. Kesimpulan penelitian ini adalah kompetensi digital pustakawan pada Perpustakaan IPDN  dalam penyelenggaraan fungsi layanan perpustakaan pada masa New Normal termasuk dalam kategori cukup baik. Peneliti merekomendasikan agar Pustakawan IPDN dapat meningkatkan keterampilan teknis dan menumbuhkan motivasi dalam meningkatkan budaya digital melalui keikutsertaan pustakawan dalam kegiatan Focus Group Discussion, Workshop dan Pendidikan serta Pelatihan. Di samping itu peneliti menyarankan agar Pustakawan IPDN dapat meningkatkan kompetensi digital melalui motivasi jenjang karir pustakawan.
Dopamine receptors in GtoPdb v.2023.1
Authors: Beaulieu Jean-Martin , Borrelli Emiliana , Carlsson Arvid , Caron Marc G. , Civelli Olivier , Espinoza Stefano , Fisone Gilberto , Gainetdinov Raul R. , Grandy David K. , Kebabian John W. , Langer Saloman Z. , Missale Maria Cristina , Neve Kim A. , Scatton Bernard , Schwartz Jean-Charles , Sedvall Goran , Seeman Philip , Sibley David R. , Sokoloff Pierre , Spano Pierre F. , Van Tol Hubert H. M.
Published: May 2023

Dopamine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Dopamine Receptors [373]) are commonly divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) families, where the endogenous agonist is dopamine.
Glucagon receptor family in GtoPdb v.2023.1
Authors: Bataille Dominique , Chan Susan L. , Delagrange Philippe , Drucker Daniel J. , Göke Burkhard , Hills Rebecca , Mayo Kelly E. , Miller Laurence J. , Salvatori Roberto , Thorens Bernard
Published: May 2023

The glucagon family of receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on the Glucagon receptor family [165]) are activated by the endogenous peptide (27-44 aa) hormones glucagon, glucagon-like peptide 1, glucagon-like peptide 2, glucose-dependent insulinotropic polypeptide (also known as gastric inhibitory polypeptide), GHRH and secretin. One common precursor (GCG) generates glucagon, glucagon-like peptide 1 and glucagon-like peptide 2 peptides [121]. For a recent review on the current understanding of the structures of GLP-1 and GLP-1R, the molecular basis of their interaction, and the associated signaling events see de Graaf et al., 2016 [90].
Lysophospholipid (LPA) receptors in GtoPdb v.2023.1
Authors: Chun Jerold , Kihara Yasuyuki , Ngo Tony , Ray Manisha , Tan Valerie P.
Published: May 2023

Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [62, 23, 91, 144]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [46], This discovery represented the beginning of the de-orphanisation of members of the endothelial differentiation gene (edg) family, as other LPA and sphingosine 1-phosphate (S1P) receptors were found. Five additional LPA receptors (LPA2,3,4,5,6) have since been identified [91] and their gene nomenclature codified for human LPAR1, LPAR2, etc. (HUGO Gene Nomenclature Committee, HGNC) and Lpar1, Lpar2, etc. for mice (Mouse Genome Informatics Database, MGI) to reflect species and receptor function of their corresponding proteins. The crystal structure of LPA1 [17, 80, 2] and LPA6 [128] are solved and indicate that LPA accesses the extracellular binding pocket, consistent with its proposed delivery via autotaxin [17]. These studies have also implicated cross-talk with endocannabinoids via phosphorylated intermediates that can also activate these receptors. The binding affinities to LPA1 of unlabeled, natural LPA and anandamide phosphate (AEAp) were measured using backscattering interferometry (pKd = 9) [92, 115]. Utilization of this method indicated affinities that were 77-fold lower than when measured using radioactivity-based protocols [143]. Targeted deletion of LPA receptors has clarified signalling pathways and identified physiological and pathophysiological roles. Multiple groups have independently published validation of all six LPA receptors described in these tables, and further validation was achieved using a distinct read-out via a novel TGFα "shedding* assay [54]. LPA has been proposed to be a ligand for GPR35 [103], supported by a study revealing that LPA modulates macrophage function through GPR35 [60]. However chemokine (C-X-C motif) ligand 17 (CXCL17) is reported to be a ligand for GPR35/CXCR8 [85]. Moreover, LPA has also been described as an agonist for the transient receptor potential (Trp) ion channels TRPV1 [96] and TRPA1 [65]. All of these proposed non-GPCR receptor identities require confirmation and are not currently recognized as bona fide LPA receptors.
Neuromedin U receptors in GtoPdb v.2023.1
Authors: Al-hosaini Khaled , Bloom Stephen R. , Hedrick Joseph , Howard Andrew , Jethwa Preeti , Luckman Simon , Raddatz Rita , Semjonous Nina , Willars Gary B.
Published: May 2023

Neuromedin U receptors (provisional nomenclature as recommended by NC-IUPHAR [30]) are activated by the endogenous 25 amino acid peptide neuromedin U (neuromedin U-25, NmU-25), a peptide originally isolated from pig spinal cord [92]. In humans, NmU-25 appears to be the sole product of a precursor gene (NMU, P48645) showing a broad tissue distribution, but which is expressed at highest levels in the upper gastrointestinal tract, CNS, bone marrow and fetal liver. Much shorter versions of NmU are found in some species, but not in human, and are derived at least in some instances from the proteolytic cleavage of the longer NmU. Despite species differences in NmU structure, the C-terminal region (particularly the C-terminal pentapeptide) is highly conserved and contains biological activity. Neuromedin S (neuromedin S-33) has also been identified as an endogenous agonist [97]. NmS-33 is, as its name suggests, a 33 amino-acid product of a precursor protein derived from a single gene and contains an amidated C-terminal heptapeptide identical to NmU. NmS-33 appears to activate NMU receptors with equivalent potency to NmU-25.
Angiotensin receptors in GtoPdb v.2023.1
Authors: Alexander Wayne , Bernstein Kenneth E. , Catt Kevin J. , De Gasparo Marc , Dhanachandra Singh Khuraijam , Eguchi Satoru , Escher Emanuel , Goodfriend Theodore L. , Horiuchi Mastgugu , Hunyady László , Husain Ahsan , Inagami Tadashi , Karnik Sadashiva , Kemp Jacqueline , Thomas Walter G. , Timmermans Pieter B. M. W. M. , Tirupula Kalyan , Unal Hamiyet , Unger Thomas , Vanderheyden Patrick
Published: May 2023

The actions of angiotensin II (Ang II) are mediated by AT1 and AT2 receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Angiotensin receptors [63, 155]), which have around 30% sequence similarity. The decapeptide angiotensin I, the octapeptide angiotensin II and the heptapeptide angiotensin III are endogenous ligands. losartan, candesartan, olmesartan, telmisartan, etc. are clinically used AT1 receptor blockers.
Eye Controlled Mouse
Authors: Hundalekar Abhishek , Pingale Siddesh , Naidu Vamshi , Trivedi Prof. Khushabu
Published: May 2023

Abstract: Numerous individuals who have neuro-locomotor deficits or are disabled by injury are unable to use PCs for abecedarian tasks, for example, sending or receiving dispatches, scouring the web, watching their TV programme, or stirring filmland. In a previous study, eyes were set up to be a great candidate for ubiquitous computing since they always move when they engage with calculating gear. Using this underlying knowledge from eye movements, these instances might be renewed using computers. For this aim, we offer a mouse gesture control mechanism that can only be used by mortal eyes. The goal of this study is to provide an open-source generic eye- gesture control system that can efficiently capture eye movements and allow the stoner to do conduct counterplotted to specified eye movements gestures via computer camera. After identifying it on the stoner's face, it tracks the pupil's motions. It must be accurate in real time for the stoner to use it comfortably, just like any other everyday prejudice.
Influence of Fresh Concrete Properties on the Mechanical Properties of Hardened Concrete
Authors: Pandey Rohit , Sharma Rahul
Published: May 2023

Abstract: Characteristics of hard concrete such as compressive strength are significantly affected by freshly prepared concrete properties. The properties of fresh concrete affect the future performance of structures. Compressive strength is found to be major parameter indicating condition of any concrete structures. In this work affect of basic properties such ratio of cement to aggregate; water to cement ratio, workability and density of fresh concrete on the compressive strength is evaluated and a regression model is developed.
Automatic Text Summarization
Authors: Jawale Sakshi , Londhe Pranit , Kadam Prajwali , Jadhav Sarika , Kolekar Rushikesh
Published: May 2023

Abstract: Text Summarization is a Natural Language Processing (NLP) method that extracts and collects data from the source and summarizes it. Text summarization has become a requirement for many applications since manually summarizing vast amounts of information is difficult, especially with the expanding magnitude of data. Financial research, search engine optimization, media monitoring, question-answering bots, and document analysis all benefit from text summarization. This paper extensively addresses several summarizing strategies depending on intent, volume of data, and outcome. Our aim is to evaluate and convey an abstract viewpoint of the present scenario research work for text summarization.
AI Enabled Chatbot for regulating Mental Health
Authors: Tomar Kirti , Khushwaha Anjali , Giri Ankit , Banoth Sreenu
Published: May 2023

Abstract: The most important healthcare questions affecting present-day human people are those related to mental health. Young adults and individuals of working age are more inclined to experience these troubles that have a detrimental effect on the person, his or her family, job, society, and economy. Conventional mental health care aids, while very successful, cannot be scaled until they meet the growing demand from affected individuals, as explained in the first two years of the COVID-19 epidemic. To begin with, it is supposed that there are 792 million families globally that have mental health issues and ailments. That equates to 1 in 10 people worldwide. Conversational assistants, or chatbots, are a recent science creativeness that has been efficiently adapted for mental health management to present first-level help for such individuals. Compared to face-to-face consultations, people are more forthcoming in online chats. Traditional methods for sentiment analysis and consoling may not be effective with adolescents because they are reluctant to express their negative emotions in personal interaction. As a result, this project places a firm attention on utilizing virtual programs to recognize depressing or anxious symptoms in individuals and control their stress.
Online Voting System Using Blockchain Technology
Authors: Khude Divya
Published: May 2023

Abstract: An online voting system that utilizes blockchain technology is a promising solution for conducting elections in a secure and transparent manner. The decentralized and distributed nature of the blockchain ledger ensures that every vote is recorded accurately and cannot be tampered with or altered without detection. This is because every node on the blockchain network has a copy of the ledger, making it virtually impossible to manipulate election results. One of the biggest advantages of blockchainbased voting systems is that they allow voters to cast their ballots from anywhere, as long as they have an internet connection. This makes voting more accessible and convenient for people who might have difficulty getting to a polling station. Additionally, blockchain technology allows for the verification of voter identity and prevents double voting, ensuring that every vote is legitimate and counted accurately. Another benefit of blockchain-based voting systems is their resistance to cyber attacks. The decentralized nature of the blockchain network makes it extremely difficult for hackers to compromise the system, as they would need to gain control of a majority of the nodes on the network. Additionally, the transparent nature of blockchain-based voting systems makes them more trustworthy and helps to prevent voter fraud.
Analysis on Automobile Reviews using Machine Learning Techniques
Authors: Preethi Dr. B. Meena , Kavyasri Ms. G. P. , Akshaya Ms. V. S.
Published: May 2023

Abstract: Automobile reviews provide a valuable opportunity for sentiment analysis in order to gain a better understanding of consumer opinions and improve product quality. As a result of the complexity of natural language and differences in user opinions, accurate and robust sentiment analysis by computer models remains challenging. Traditional machine learning algorithms such as Support Vector Machines (SVM) and Naive Bayes (NB) have been used for sentiment analysis on textual data. They can, however, be limited by the heterogeneity of user opinions and language variations. In contrast, deep learning models and natural language processing have shown great promise in sentiment analysis. In particular, the VADER (Valence Aware Dictionary and sentiment Reasoner) algorithm has been proposed as a powerful tool for sentiment analysis on social media texts, and has shown promising results in other domains as well. In this work, The aim is to achieve accurate sentiment analysis on automobile reviews by comparing the accuracy performance of SVM, NB, and the VADER algorithm.
Power Electronic Technology in Smart Grid Prospect
Authors: Nyako Shamsuddeen Ibrahim
Published: May 2023

bstract: Electric energy is an extremely complex energy source that has become increasingly important in industry, agriculture, the economy, and daily life. The annual increase in electricity consumption symbolizes more stable economic growth in China, but there are still some problems. Power outages, low power quality, and complex power grid structures are issues that the power grid is facing. The development of power systems, the emergence of power electronics technology, and continuous research on power electronics technology can provide a feasible solution for alleviating and overcoming power problems. This article first summarizes the basic principles of power electronics technology in the construction of intelligent fields and then analyses the current examples of smart grid applications, including high-voltage direct current transmission, high-frequency technology, and intelligent switch technology. Finally, the possibility and potential for the development of power electronics technology were pointed out.
Improving Self-Confidence, Enthusiasm, And Learning Satisfaction With mE-Book Practical Arabic Syntax and ARIAS Learning Model
Authors: Anisatin Luthfi , Khusairi Muhammad , Nurhidayati Nurhidayati , Ismail Ali Mahmud Al-Asmai
Published: May 2023

This study aimed to determine the level of effectiveness of mE-Book practical Arabic syntax with the ARIAS learning model in increasing self-confidence, enthusiasm for learning, learning satisfaction, and student learning outcomes. The research method used is a quantitative approach with a one group pretest-posttest design model with data collection techniques in the form of observations, questionnaires, tests, and documentation. Data analysis techniques are obtained from the distribution of normality, hypothesis testing and n-gain. This research was conducted at ma'had Nurul Furqon Malang in grade X of high school with a total of 20 students. The results of the study prove that the use of mE-Book practical Arabic syntax with the ARIAS learning model can effectively increase self-confidence, student enthusiasm, learning satisfaction, and student learning outcomes.
Analysis of the Textbook Ayo Belajar Bahasa Arab according to Jean Piaget’s Cognitive Development Theory
Authors: Huwaida Jaziela , Himam Alin Safaraz , Nur Fauziah Siti Anne Barkah , BinZaid Abdul Hafidz , Rochmat Cecep Sobar
Published: May 2023

This study aimed to determine the quality of textbook content Ayo Belajar Bahasa Arab in terms of the cognitive aspects of Jean Piaget’s Cognitive Development Theory. This research is a qualitative analytical study by library research methodology. The main data sources are the textbooks of Ayo Belajar Bahasa Arab and lots of the latest studies. The analysis was done by analyzing the content of relevant data using the cognitive development qualifications of Jean Piaget. The results of this study are concluded that the purpose of the textbooks studied is in accordance with the abilities of children aged 11 or grade 5 elementary school according to Jean Piaget's theory of cognitive development. Matching one thing with another, understanding conversations, discussing and arguing with the guidance of the teacher, and classifying sentences from Arabic to Indonesian are the abilities students need to study the textbook according to their goals. Appropriate book material is learning vocabulary, practicing conversation, reading, and constructing sentences and exercises. The analysis results show that Ayo Belajar Bahasa Arab’s book achieves excellent results on the suitability and appropriateness to the theory of cognitive development of Jean Piaget.
INTERVENSI BULOG TERHADAP KELANGKAAN BERAS MENURUT PERSPEKTIF TAS’IR AL-JABARI
Authors: Bismi Khalidin  , Rahmi Wahyuni
Published: May 2023

Beras pada waktu tertentu dapat mengalami kelangkaan dikarenakan berbagai macam permasalahan, Perum Bulog memiliki wewenang untuk mengatasi kelangkaan beras dengan melakukan intervensi. Pertanyaan penelitian dalam skripsi ini adalah bagaimanakah intervensi Perum Bulog Divisi Regional Aceh terhadap kelangkaan beras, bagaimanakah upaya Perum Bulog dalam menangani kelangkaan beras dan bagaimanakah perspektif tas’ir al-jabari terhadap intervensi Perum Bulog pada kelangkaan beras. Penelitian ini menggunakan penelitian lapangan (field research) dan penelitian kepustakaan (library research). Jenis penelitian ini adalah suatu penelitian yang menunjukkan pemecahan permasalahan yang aktual dengan jalan menyusun, menganalisa, dan menginterprestasi seluruh data yang berhubungan dengan penulisan. Hasil penelitian mengenai intervensi Perum Bulog terhadap kelangkaan beras dimana Bulog mengintervensi secara rutin setiap permasalahan yang terjadi berdasarkan surat perintah dari Bulog Pusat dan bekerjasama dengan Dinas Pertanian, Badan Pusat Statistik dan Dinas Perindustrian dan Perdagangan untuk melakukan operasi pasar yang bertujuan untuk mencegah terjadinya kelangkaan beras. Upaya Bulog dalam menangani kelangkaan beras Bulog akan melakukan operasi pasar dengan menyalurkan stok cadangan beras yang ada di gudang Bulog ke setiap toko yang ada di Aceh yang telah memiliki ikatan kerjasama, dan upaya terakhir yaitu melakukan impor beras. Intervensi yang dilakukan oleh Perum Bulog sesuai dengan konsep tas’ir al-jabari. Konsep tas’ir al-jabari ini dapat dilakukan oleh Bulog dalam menangani masalah kelangkaan beras. Dari paparan di atas dapat disimpulkan bahwa, intervensi pemerintah terhadap kelangkaan beras dapat dilakukan oleh Perum Bulog sesuai dengan perintah dari Bulog Pusat dimana intervensi yang dilakukan sesuai dengan hukum islam karena dilihat dari kemaslahatan masyarakat.
KEDUDUKAN PENCATATAN HUTANG PERSPEKTIF FIQH MUAMALAH
Authors: Riadhus Sholihin
Published: May 2023

Perspektif Islam tentang akad utang-piutang masuk dalam akad sosial.Akad utang dibolehkan berdasarkan Alquran, hadis, dan ijmak para ulama.Hanya saja, para ulama tidak pada dalam menetapkan kedudukan hokum pencatatan utang. Jumhur ulama menyatakan pencatatan utang tidak wajib, sementara pendapat sebagian lainnya menyatakan wajib. Mutawallī Al-Sya’rāwī merupakan salah satu tokoh yang berpendapat wajibnya mencatat utang. Hal ini cenderung berbeda dengan pendapat mayoritas ulama. Pendapat al-Sya’rāwī menarik diteliti karena ada relevansinya dengan konteks akutansi modern. Fokus yang menjadi perhatian penelitian ini adalah untuk mengetahui Mutawallī al-Sya’rāwī mewajibkan pencatatan hutang, danmengetahui dalil dan metode istinbāṭ yang digunakan Mutawallī al-Sya’rāwī. Penelitian ini dilakukan dengan pendekatan study dipustaka (library research). Data-data yang dikumpulkan dianalisis melalui cara deskriptifanalisis. Hasil penelitian menunjukkan bahwa menurut Muḥammad Mutawallī al-Sya’rāwī, kedudukan hukum pencatatan utang adalah wajib. Hal ini didasari oleh perintah dalam Alquran QS. al-Baqarah ayat 282 yang mewajibkan menulis utang, serta beberapa manfaat dan kegunaan catatan utang.Dalil yang digunakan Muḥammad Mutawallī al-Sya’rāwī mengacu pada ketentuan QS. al-Baqarah ayat 282 dan QS. Yūsuf ayat 55. Ketentuan QS. al-Baqarah ayat 282 digunakan dalam soal perintah wajib mencatat utang. Sementara ketentuan QS. Yūsuf ayat 55 menurut Muḥammad Mutawallī al-Sya’rāwī berkaitan dengan syarat pencatat utang. Adapun metode istinbāṭ yang ia gunakan cenderung pada dua penalaran sekaligus, yaitu bayanī dan istiṣlāḥī. Metode bayanī tempat pada telaah atas lafaz “فَٱكۡتُبُوهُۚ”, yaitu sebagai lafaz amar “أمر” yang menunjukkan makna perintah wajib. Sementara penalaran istiṣlāḥī yang ia gunakan terlihat saat ia menerangkan kegunaan dan manfaat dari pencatatan utang. Menurutnya, pencatatan utang digunakan untuk melindungi hak dari pemilik harta, atau demi manfaat dan kemaslahatan kedua pihak yang melakukan akad.
ANALISIS RATE MARGIN MURABAHAH PADA TRANSAKSI JUAL BELI RUMAH SUBSIDI KPR BTN SYARIAH DALAM PERSPEKTIF HUKUM ISLAM
Authors: Nurdin Ridwan , Jariah Sri Ainun
Published: May 2023

Pembiayaan murabahah pada perhitungan marginnya menggunakan sistem perhitungan anuitas untuk memudahkan akumulasi cicilan nasabah. Perhitungan anuitas itu sendiri merupakan hasil adopsi dari perhitungan bunga kredit pada bank konvensional. Sehingga perhitungan anuitas ini sangat memaksimalkan keuntungan dengan penentuan yang mengedepankan analisis risiko, jangka waktu dan BI rate untuk menentukan rate marginnya. Rumusan masalah ini yaitu bagaimana tingkat margin yang disepakati oleh pihak bank dan nasabah dalam pembiayaan murabahah terhadap transaksi jual beli rumah subsidi KPR BTN syariah KC Banda Aceh, serta bagaimana perspektif hukum Islam terhadap transaksi jual beli rumah subsidi KPR BTN Syariah KC Banda Aceh dalam penerapan rate margin murabahah. Metode penelitian ini menggunakan deskriptif analisis dengan menggunakan data primer berupa wawancara langsung ke tempat instansi terkait (field research) menggunakan teknik wawancara dan observasi serta penelitian kepustakaan (library research). Dari hasil penelitian diperoleh bahwa rate margin murabahah pada transaksi rumah subsidi KPR BTN syariah bersifat fixed (tetap) dan KPR ini dihitung menggunakan kalkulasi anuitas. Pada pembiaayan murabahah ini dari praktik pendapatan margin pada perumahan KPR bersubsidi pihak bank hanya mendapatkan 5% keuntungan, 5% lagi menjadi tanggulangan pemerintah. Rate margin murabahah pada transaksi jual beli rumah subsidi KPR BTN syariah tidak ada unsur  riba, karena padaa skema pembiayaan murabahah perurumah KPR ini sudah jelas berapa harga pokok rumah ditambah margin keuntungan bank serta disepakati antara kedua belah pihak serta margin dalam pembiayaan muirabahah ini tetap tidak naik turun seperti bank konvensional
KEWENANGAN MAKAMAH SYAR’IYAH DI ACEH DALAM EKSEKUSI JAMINAN FIDUSIA BERDASARKAN PUTUSAN MAKAMAH KONSTITUSI PASCA HADIRNYA QANUN NO 11 TAHUN 2018 LEMBAGA KEUANGAN SYARIAH DI ACEH
Authors: Fajri IKhsan
Published: May 2023

Perselisihan Sengketa Ekonomi Syariah di Aceh Pasca diberlakukan Qanun No 11 Tahun 2018 Tentang Lembaga Keuangan Syariah semakin meningkat, Jaminan Fidusia sebagai salah satu jaminan dalam bentuk kontrak perjanjian murabahah antara lembaga keuangan syariah dan nasabah juga acap diwarnai perselisihan di Aceh, meningkatnya jumlah sengketa dalam bentuk jaminan fidusia semakin membuat Makamah Syar’iyah secara kompetensi Absolut memiliki peran dan tanggungjawab besar dalam mengadili sengketa ekonomi syariah di Aceh. Penelitian ini bertujuan untuk mengetahui kewenangan Makamah Syar’iyah di Aceh dalam mengadili dan memutuskan berbagai permasalahan sengketa Ekonomi Syariah di Aceh serta faktor-faktor yang menyebabkan nasabah bersengketa dan lembaga keuangan syariah menyita jaminan baik melalui jalur litigasi dan non litigasi. Metode penelitian ini menggunakan desain kualitatif dengan teknik penelitian studi kasus. Jenis data yang dikumpulkan berupa data primer dan sekunder. Hasil penelitian ini sangat bermanfaat serta dapat menjadi masukan bagi pemerintah dan Lembaga Keuangan Syariah untuk melakukan mitigasi lebih cepat terkait dengan potensi sengketa ekonomi syariah dan cara penyelesaiannya di lembaga Peradilan Makamah Syar’iah di Aceh.
EFL students’ language attitudes toward virtual learning environment: A technology acceptance model
Authors: Faiqoh Avita Elok , Ashadi Ashadi
Published: May 2023

It is widely believed that L2 learners who have positive attitudes towards the target culture and its people are likely to learn the target language more effectively than those who do not possess such attitudes. As technology continues to be increasingly integrated into language learning, this article aims to explore EFL students' attitudes towards technology acceptance via Virtual Learning Environment (VLE), as well as the potential advantages of VLE in the EFL classroom. A quantitative approach was employed in this study, which involved 30 students from English language education departments at a private university in Indonesia. The students' computer attitudes were assessed using a Likert scale questionnaire with four factors, including affective, perceived usefulness, perceived control, and behavioural intention. The Technology Acceptance Model (TAM) developed by Davis (1989) was utilized as the framework to further examine these factors. The results indicated that the students had a positive attitude towards the Computer Attitude Scale (CAS) factors, which were categorized into affective, perceived usefulness, perceived control, and behavioural intention. The implications of each of these categories in the framework are discussed in relation to behaviourism theory.