bluuebunny/crossref_metadata_2025 huggingface dataset:
XI CONGRESO NACIONAL DE ALCONPAT MÉXICO (XICNAM) 2024
Authors:   CIIDIR Unidad Oaxaca del IPN., Cano Barrita Prisciliano Felipe de Jesús , Alonso Guzmán Elia Mercedes ,   UMSNH, Michoacán, Pérez López Tezozómoc ,   Centro de Investigación en Corrosión de la UACAM, Castro Borges Pedro ,   Cinvestav del IPN Unidad Mérida
Published: January 2025

Es un honor presentar las memorias del XI Congreso Nacional de Alconpat México 2024, un evento que ha reunido a destacados profesionales, investigadores y académicos del ámbito del control de calidad, patología y recuperación de las construcciones. Este congreso, celebrado en la Ciudad de Oaxaca de Juárez, Oaxaca, México, ha sido un espacio de intercambio de conocimientos, experiencias y avances tecnológicos que contribuyen al desarrollo y sostenibilidad de nuestras construcciones.
A lo largo de estas memorias, encontrarán una recopilación de las ponencias que se llevaron a cabo durante el congreso. Cada artículo refleja el compromiso y la dedicación de los participantes por mejorar las prácticas en la construcción y conservación de edificaciones y estructuras, así como por
promover la innovación en el sector.
Queremos agradecer a todos los ponentes, asistentes y patrocinadores que hicieron posible este evento. Su participación y apoyo fueron fundamentales para el éxito de este congreso y para el avance continuo de nuestra disciplina. Esperamos que estas memorias sean una fuente valiosa de información y un
referente para futuras investigaciones y proyectos. Que el conocimiento compartido aquí inspire nuevas ideas y soluciones para los desafíos que enfrentamos en la construcción, patologías y recuperación de la construcción.
Agradecemos su interés y les invitamos a seguir colaborando y participando en futuras ediciones del Congreso de Alconpat México.

Por el Comité Organizador

Prisciliano Felipe de Jesús Cano Barrita, Presidente del Comité Organizador
Elia Mercedes Alonso Guzmán, Presidente del Comité Científico
Tezozómoc Pérez López, Presidente de Comité de Premiación
Pedro Castro Borges, Presidente del Comité de Financiamiento
Autoeficacia profesional y estrés laboral en trabajadores de Lima metropolitana en tiempos de COVID-19: organizaciones saludables
Authors:   , Mendoza Martinez Martin Alonso
Published: January 2025

El objetivo del estudio fue analizar la relación entre la autoeficacia en el ámbito profesional y el estrés laboral en los empleados de una empresa privada en Lima Metropolitana durante el periodo de la COVID-19.
La metodología empleada es de tipo básico y descriptivo, con un enfoque cuantitativo. Se utilizó un diseño correlacional, no experimental y de tipo transversal. La muestra estuvo compuesta por 217 trabajadores seleccionados mediante un muestreo no probabilístico por conveniencia. Para la recolección de datos se aplicaron el Cuestionario de Autoeficacia Profesional (AU-10) y el Cuestionario de Estrés Laboral (OIT-OMS).
En los resultados, se encontró una correlación moderada entre la Autoeficacia Profesional y el Estrés en el trabajo (Rho = -.345; p < .001). Se concluyó que hay una relación significativa entre ambos factores.
Evaluation of New Zwitterionic Viscoelastic Surfactant in Carbonate Acidizing by Novel Injection Sequence: An Experimental Study
Authors: Naderi Salem Hamed , Kandowjani Alireza Ebrahimi , Sedaee Behnam , Mansouri Mehrshad , Shariati Mohsen
Published: January 2025

In matrix acidizing, chemical divertants increase the chances of proper acid distribution in the production zones. Viscoelastic surfactants (VESs) are common diverting agents due to easy removal. VES-based acid effectiveness is influenced by pH, shear rate, concentration, and type of VES. Additives such as corrosion inhibitors (CIs) and iron control agents (ICAs) affect VES-based acid performance. This study analyzes a new viscoelastic zwitterionic surfactant’s diversion efficiency via rheology measurements and coreflooding experiments.

The study aimed to optimize a diverting fluid by examining its rheological behavior at pH 4 with surfactant concentrations of 4, 6, and 8 vol% while considering the presence of additives and also explored the effects of CIs and ICAs. Single coreflooding tests determined the injection rate with the lowest PVbt (IRLPVbt) for the diverting fluid and regular acid. By parallel coreflooding tests, utilizing periodic injection method and shut-in time assessed diversion efficiency on carbonate cores with permeability contrasts ranging from 3 to 27. Post-injection computed tomography (CT)-scan images were used to monitor the development of wormholes in the cores.

The rheology analysis showed that the desired VES displayed dominant elastic properties, resembling an elastic solid. The 6 vol% VES exhibited the most favorable rheological behavior, making it the optimal choice for effective diversion. The presence of CI and ICA additives together at concentrations of 1 and 0.5 vol%, respectively, not only had no negative effects but also enhanced the rheological behavior. Through the periodic injection method, injecting the VES-based diverting fluid equivalent to 0.5 pore volume (PV) of the high-permeability core (PVHP), followed by a shut-in time, and subsequent regular acid injection in parallel cores, showed the highest diversion efficiency. The study found that within a permeability contrast range of 3–5, the diversion efficiency was infinite, indicating highly effective diversion, while it measured at 95.9% for a permeability contrast of 32. Increasing the injection volume of the VES-based diverting fluid above 0.5 PVHP decreased the diversion efficiency. This study suggests a new carbonate rock acidizing procedure that could enhance well stimulation efficiency.
Careful design of Large Language Model pipelines enables expert-level retrieval of evidence-based information from conservation syntheses
Authors: Iyer Radhika , Christie Alec , Madhavapeddy Anil , Reynolds Sam , Sutherland William , Jaffer Sadiq
Published: January 2025

Wise use of evidence to support efficient conservation action is key to tackling biodiversity loss with limited time and resources. Evidence syntheses provide key recommendations for conservation decision-makers by assessing and summarising evidence, but are not always easy to access, digest, and use. Recent advances in Large Language Models (LLMs) present both opportunities and risks in enabling faster and more intuitive systems to access evidence syntheses and databases. Such systems for natural language search and open-ended evidence-based responses are pipelines comprising many components. Most critical of these components are the LLM used and how evidence is retrieved from the database. We evaluate the performance of ten LLMs across six different database retrieval strategies against human experts in answering synthetic multiple-choice question exams on the effects of conservation interventions using the Conservation Evidence database. We found that LLM performance was comparable with human experts over 45 filtered questions, both in correctly answering them and retrieving the document used to generate them. Across 1867 unfiltered questions, LLM performance demonstrated a level of conservation-specific knowledge, but this varied across topic areas. A hybrid retrieval strategy that combines keywords and vector embeddings performed best by a substantial margin. We also tested against a state-of-the-art previous generation LLM which was outperformed by all ten current models - including smaller, cheaper models. Our findings suggest that, with careful domain-specific design, LLMs could potentially be powerful tools for enabling expert-level use of evidence syntheses and databases. However, general LLMs used ‘out-of-the-box’ are likely to perform poorly and misinform decision-makers. By establishing that LLMs exhibit comparable performance with human synthesis experts on providing restricted responses to queries of evidence syntheses and databases, future work can build on our approach to quantify LLM performance in providing open-ended responses.
Volume buffering in multi-component phase separation
Authors: Michaels Thomas , de Monchaux-Irons Logan , Han Nina , Frühbauer Benjamin , Jiang Jianning , Allain Frédéric , Jagannathan Madhav , Emmanouilidis Leonidas
Published: January 2025

The concentrations of biomolecules in cells are subject to substantial fluctuations, but how cells deal with such variability is still poorly understood. Recently the formation of biomolecular condensates through liquid-liquid phase separation has been proposed as a powerful buffering mechanism to enable local protein concentration to be robust to expression fluctuations. Here, using theory, simulations, in vitro and in vivo experiments we show an orthogonal noise buffering mechanism mediated by phase separation, whereby the total volume of condensates is buffered when the global protein concentration changes. Spatial control mechanisms are needed to robustly localize cellular activities and volume buffering by phase separation offers such a mechanism. Our work thus provides new insights into the potential role of condensates in regulating spatial activities in cells.
Sildenafil Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells and Inhibits Bone Loss by Affecting the TGF-β Signaling Pathway
Authors: Hu Menglong , Wu Likun , Wei Erfan , Pan Xingtong , Zhu Qiyue , Xiuyun Xv , Lv Letian , Dong Xinyi , Liu Hao , Liu Yunsong
Published: January 2025

Background
Osteoporosis, a common bone disorder, is primarily managed pharmacologically. However, existing medications are associated with non-trivial side-effects. Sildenafil, which already finds many clinical applications, promotes angiogenesis and cellular differentiation. Osteoporotic patients often exhibit a reduced intraosseous vasculature and impaired cellular differentiation; sildenafil may thus usefully treat osteoporosis.
Methods
Here, the effects of sildenafil on the osteogenic differentiation of human mesenchymal stem cells (hMSCs) were explored, as were the molecular mechanisms in play. We treated hMSCs with varying concentrations of sildenafil and measured cell proliferation and osteogenic differentiation in vitro. We used a mouse model of subcutaneous ectopic osteogenesis to assess sildenafil's effect on hMSC osteogenic differentiation in vivo. We also explored the effects of sildenafil on bone loss in tail-suspended (TS) and ovariectomized (OVX) mice. Mechanistically, we employed RNA-sequencing to define potentially relevant molecular pathways.
Results
Low sildenafil concentrations significantly enhanced osteogenic hMSC differentiation; the optimal sildenafil concentration may be 10 mg/L. Sildenafil mitigated osteoporosis in OVX and TS mice. Low sildenafil concentrations probably promoted hMSC osteogenic differentiation by acting on the transforming growth factor-β (TGF-β) signaling pathway.
Conclusions
In conclusion, low sildenafil concentrations enhanced hMSC osteogenic differentiation and inhibited bone loss. Sildenafil may usefully treat osteoporosis. Our findings offer new insights into the physiological effects of the material.
Extracellular Matrix Dysfunction Drives Synaptic Pathology in Schizophrenia
Authors: Unzueta-Larrinaga Paula , Cuesta-Vega Esteban , Barrena-Barbadillo Rocío , Olabarrieta Estibaliz , Recio-Barbero Maria , Horrillo Igor , Mentxaka Oihane , Segarra Rafael , Meana J. Javier , Nacher Juan , Diez-Alarcia Rebeca , Callado Luis F. , Urigüen Leyre
Published: January 2025

Schizophrenia is a complex disorder with strong evidence implicating neurodevelopmental abnormalities in its pathophysiology. Olfactory neuroepithelial cells from patients provide a unique platform for studying neurodevelopmental processes. These cells can be cultured into neurospheres and differentiated into neurons, allowing the study of patient-specific alterations related to the disorder. In this study, we utilized olfactory neuroepithelial cells from patients with schizophrenia and controls to explore putative neurodevelopmental dysregulations.
RNA-sequencing of neurospheres transcriptome revealed significant alterations in extracellular matrix-related gene expression, suggesting extracellular matrix dysregulation as an underlying contributor to schizophrenia etiopathogenesis.Upon differentiation of olfactory neuroepithelial cells into neurons, transcriptomic analysis identified a significant downregulation of genes involved in synaptic organization and extracellular matrix interactions. To validate these findings, we quantified the protein levels of these genes in olfactory neuroepithelium-derived neurons and in postmortem dorsolateral prefrontal cortex tissue from schizophrenia patients and matched controls. Consistent with our transcriptomic data, schizophrenia subjects exhibited decreased levels of L1CAM, SCG2, and NPTXR proteins. Furthermore, we identified a correlation between the protein levels of L1CAM and NPTXR in the brains of individuals with schizophrenia, a relationship that was absent in control subjects.
Our findings provide robust evidence for extracellular matrix and synaptic dysregulation in schizophrenia, linking neurodevelopmental disruptions to molecular alterations in both patient-derived cellular models and postmortem brain. These results underscore the utility of olfactory neuroepithelium cells as a model for studying the neurodevelopmental basis of schizophrenia. They also highlight extracellular matrix-related pathways as potential targets for future search of biomarkers and therapeutic development.
Evaluation of chemical elements as potential biomarkers in the treatment of goat mastitis
Authors: Uzoka Ugonna Henry , Fujikura Juliana Miwa , Polveiro Richard Costa , Caldeira Jéssica Lobo Albuquerque , Netto Maria Júlia Fernandes , Menezes Luísa Maria Souza , Cesário Cristiane do Carmo , Valente Fabricio Luciani , Moreira Maria Aparecida Scatamburlo
Published: January 2025

Mastitis represents a significant inflammatory condition in dairy goat herds, causing substantial economic losses through reduced milk production and increased veterinary interventions. The escalating challenge of multidrug-resistant bacteria has prompted research into alternative therapeutic strategies, including milk microbiota transfer (MMT) and phytochemical treatments. This study evaluated milk chemical elements as biomarkers during two alternative treatments for Staphylococcus warneri-induced mastitis: milk microbiota transplantation and intra-mammary infusion of 7-epiclusianone, a phytochemical derived from Garcinia brasiliensis fruit. The experimental design involved seven female Parda Alpina goats, with six goats infected with S. warneri treated using milk from a healthy donor. Intra-mammary 7-epiclusianone was administered two days post-MMT. The right udder received the treatments, with the left udder serving as a control. Elemental analysis of 120 milk samples was performed using scanning electron microscopy coupled with X-ray dispersive spectroscopy, monitoring trace and macro elements. Significant elemental composition variations were observed, with iron, copper, and zinc showing immediate responsiveness from the first day of MMT. Most elements exhibited minor fluctuations, returning to control levels by the treatment's conclusion. The 7-epiclusianone treatment maintained stable elemental concentrations when compared to the control and a reduction in sodium levels was observed. The study identifies zinc, copper, iron, and sodium as promising biomarkers during goat mastitis treatment. The combined MMT and 7-epiclusianone approach aligned milk elemental level with the control levels post treatment, offering a non-invasive method for monitoring mastitis treatment efficacy. Future research should validate these elemental biomarkers across larger and more diverse goat populations.
Glucose monitoring, support systems and motivating factors among newly diagnosed type2 diabetic clients: an explorative study in the Upper East Region, Ghana
Authors: Asebiga Clement Asoya , Bam Victoria , Lomotey Alberta Yemotsoo
Published: January 2025

Background: The World Health Organization (WHO) estimated that over 463 million people are living with Diabetes mellitus which is likely to be doubled by the year 2045 meaning 55000 new cases daily. Type 2 Diabetes (T2D) accounts for over 90% of these cases. The situation is worse in Africa due to the poor diagnostic systems. In Ghana, the condition affects over 2.4 million people. The need for the current study is underscored by the emerging importance of data on patient’s experiences coupled with the gap in knowledge on the experiences of newly diagnosed T2D clients. The objective of this study is therefore to explore the experiences of newly diagnosed T2D clients on glucose monitoring, support system availability and motivating factors for them to continue to adhere to their glucose monitoring as a life style modification measure.
Methods: A Qualitative explorative design was used targeting clients diagnosed with T2D within the last 6 months before data collection. A purposive sampling technique was used to recruit 15 participants. In-depth face to face interview was conducted individually using a semi structured questionnaire. Data was transcribed and analyzed using thematic approach.
Results: The findings of the study indicates that T2D clients are faced with unique challenges in glucose monitoring as a lifestyle modification and as a result commit avoidable errors due to lack of knowledge such as; waiting to feel unwell before going for reviews and not disclosing their condition and its management including glucose monitoring to others. Cost was their number one challenge when it comes to glucose monitoring. Their main source of support was found to be from close relatives. Checking and getting improved results was motivating to them
Recommendation and Conclusion: Challenges faced by T2D clients’ results in them committing errors that could have been avoided as new clients which points to lack of knowledge. An intensification of public education on the condition and the need for regular glucose monitoring and further studies on how these experiences of cost, access to care and lack of support affects clients are recommended.
Evaluation of efficacy of sexual novelty as a novel therapeutic strategy to treat Hypoactive Sexual Desire Disorder in women in monogamous heterosexual relationships attributing reduced sexual desire to sexual boredom: A prospective randomized study
Authors: Bhat Gajanan , Shastry Anuradha
Published: January 2025

Hypoactive Sexual Desire Dysfunction (HSDD) in women has a complex origin, and addressing modifiable factors can lead to the best outcomes. One contributing factor is sexual boredom, particularly in women in monogamous relationships and we decided to evaluate sexual novelty as a therapeutic strategy in such women using prospective randomized study design These women were recruited following screening using a Decreased Sexual Desire Screener (DSDS). Participants’ baseline sexual boredom was assessed using the Sexual Boredom Scale (SBS). Reasons for sexual boredom were identified, and customized novelty packages were developed accordingly. The participants were divided into two groups: Group A received psychotherapy alone (n = 196), while Group B (n = 202) received psychotherapy along with a customized sexual novelty package. Sexual desire levels were measured and compared at baseline and after a six-month intervention using the Elements of Desire Questionnaire (EDQ). The groups were similar in age, duration of monogamy, SBS scores, and baseline EDQ scores. Post-intervention results indicated that the sexual novelty group experienced a statistically significant improvement in EDQ scores. Moreover, multiple regression models showed that lower age of the participant and a longer period of monogamy adversely affected sexual desire.
Personalized Prediction Model Generated with Machine Learning for Kidney Function One Year After Living Kidney Donation
Authors: Oki Rikako , Hirai Toshihio , Iwadoh Kazuhiro , Kijima Yu , Hashimoto Hiroyuki , Nishimura Yasunori , Banno Taro , Unagami Kohei , Omoto Kazuya , Shimizu Tomokazu , Hoshino Junichi , Takagi Toshio , Ishida Hideki
Published: January 2025

Living kidney donors typically experience approximately a 30% reduction in kidney function after donation, although the degree of reduction varies among individuals. This study aimed to develop a machine learning (ML) model to predict serum creatinine (Cre) levels at one year post-donation using preoperative clinical data, including kidney-, fat-, and muscle-volumetry values from computed tomography. A total of 204 living kidney donors were included. Symbolic regression via genetic programming was employed to create an ML-based Cre prediction model using preoperative clinical variables. Validation was conducted using a 7:3 training-to-test data split. The ML model demonstrated a median absolute error of 0.079 mg/dL for predicting Cre. In the validation cohort, it outperformed conventional methods (which assume post-donation eGFR to be 70% of the preoperative value) with higher R² (0.58 vs. 0.27), lower root mean squared error (5.27 vs. 6.89), and lower mean absolute error (3.92 vs. 5.8). Key predictive variables included preoperative Cre and remnant kidney volume. The model was deployed as a web application for clinical use. The ML model offers accurate predictions of post-donation kidney function and may assist in monitoring donor outcomes, enhancing personalized care after kidney donation.
Safety and Efficacy of Atezolizumab/Bevacizumab in unresectable Hepatocellular Carcinoma - a multicentric study
Authors: Babu Merin , Komaranchath Ashok Sebastian , Valsan Arun , Warrier Arun R , Rakesh M P , Jose Wesley M , Haridas Nikhil K , Soman Sumi , Nair Manjima P , Sadasivan Shine , Menon Abhinav , Thabrez Mohammed , Pavithran Keechilat
Published: January 2025

Purpose: Immunotherapy with atezolizumab and bevacizumab is the current first-line standard of care for unresectable hepatocellular carcinoma (HCC). This study aimed to evaluate the safety and efficacy profile of atezolizumab-bevacizumab in our Indian population, as there are limited studies.
Patients and methods: All patients diagnosed with advanced HCC who received systemic therapy with atezolizumab bevacizumab as the first- or second-line therapy were included in the study. Data were collected retrospectively from two comprehensive cancer centres between September 2020 and May 2024 by accessing the medical records. As per the IMBrave 150 trial, patients were given atezolizumab 1200 mg and bevacizumab 15 mg/kg intravenously every 3 weeks. Demographic details, adverse events, and radiological data were collected.
Results: We included one hundred and four patients with a median age of 67 years. Majority of the patients had a compensated cirrhosis (n = 77; 74%), while Child Pugh class B cirrhosis was observed in 19 patients (18%), and class C cirrhosis in 3 patients (3%). The median OS was 14.8 (95% CI; 6.8 – 22.9) months and median PFS in the whole cohort was 6.2 months (95% CI; 2.5 – 9.9) months.
Conclusion: The real-world OS and PFS rates were lower than those of the IMBrave trial, most likely because 43% of our patients did not meet the inclusion criteria. We conclude that the combination of atezolizumab and bevacizumab is a safe and effective option for patients with unresectable hepatocellular carcinoma patients with manageable toxicities.
Trends in socio-economic level and accessibility to healthcare of households in Eastern Democratic Republic of Congo from 2011 to 2023: Documentary review of South Kivu
Authors: Mugisa Anicet , Bigirinama Rosine , Kisembo Claude , Mulume Armand , Lurhangire Emmanuel , Bisimwa Ghislain , Hermans Michel P , Mwene-batu Pacifique
Published: January 2025

Background
In the Democratic Republic of Congo (DRC), the population's standard of living has deteriorated over the years as a result of the country's worsening socio-economic, security and political context. The aim of this study was to assess changes in the socio-economic level and accessibility to healthcare in health zones of South Kivu province between 2011 and 2023.
Methods
A literature review was carried out on changes in the socio-economic level of households in the province of South Kivu and access to healthcare from 2011 to 2023. The search was carried out in the PubMed and Google Scholar databases and on non-governmental organizations (NGO) websites, using keywords relating to socio-economic level and access to healthcare in South Kivu and the DRC.
Results
A total of 11 documents were selected out of 74 consulted for thematic analysis. Data from South Kivu show various changes in households. The proportion of female heads of household increased from 14% in 2011 to 43.8% in 2023. Illiteracy among household heads fell slightly, reaching 23% in 2023. Mean household size increased from 6.8 to 10 persons. Mean monthly income fell from USD 190 to 67 between 2013–2014 and 2023. The number of episodes of illness per household also increased, from 1.1 in 2011 to 2.3 in 2023. Despite a majority of households living less than 30 minutes from a healthcare facility, self-medication and sale of assets to cover healthcare costs became more common.
Conclusion
The socio-economic situation in South Kivu is deteriorating, with falling income and the majority of the population living below poverty line, impacting access to health services in spite of favourable regional access. The number of female heads of household likely increased partly as a result of armed conflicts conducing to death or physical disability of spouses. In terms of water, hygiene and sanitation (WASH), improved access to drinking water was offset by unhygienic latrines and food security challenges. Targeted action is needed to improve access to basic services and promote sustainable development with a view to achieving universal health coverage in the DRC.
HDAC8-mediated CAPZB desuccinylation enhances cytoskeleton remodeling to promote idiopathic pulmonary fibrosis
Authors: Liu Bo , Kang Di , Zhang Jinjin , Wang Yujie , Li Rongrong , Lv Changjun , Zhai Nailiang , Song Xiaodong , Zhang Songzi , Li Hongbo
Published: January 2025

Background
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial pneumonia of unknown etiology. Abnormal regulation of the cytoskeleton is a key factor driving pulmonary fibrogenesis. However, the molecular mechanisms of cytoskeleton remodeling in pulmonary fibrosis remains obscure.
Methods
Succinylome analysis of lung tissues from bleomycin (BLM)-treated mice was performed. Key modified proteins and sites were identified through Clusters of Orthologous Groups (COG) functional classification statistics and liquid chromatograph-mass spectrometer (LC-MS/MS) analysis. F-actin-capping protein subunit beta (CAPZB) was selected for further investigation. Gain- and loss-of-function and modified site mutation studies were conducted to assess the function of CAPZB in pulmonary fibrosis and the effect of succinylation on it. Then, Co-immunoprecipitation (Co-IP) and functional studies were used to identify the desuccinylase for CAPZB. Finally, adenoviral vectors were constructed to evaluate the effect of CAPZB on pulmonary fibrosis in vivo.
Results
A total of 910 lysine succinylation sites in 388 proteins were differentially expressed between the BLM-treated mice and the sham group. COG functional classification statistics showed that 42 proteins were classified into cytoskeleton-related proteins. Among these proteins, the succinylation level of CAPZB was significantly decreased. And lysine57 (K57), lysine95 (K95), and lysine235 (K235) were identified as the desuccinylation sites of CAPZB in pulmonary fibrosis. Gain- and loss-of-function studies revealed that CAPZB restrained cytoskeletal remodeling to inhibit pulmonary fibrogenesis. The effect of succinylation modification on CAPZB function revealed that CAPZB desuccinylation inhibited its capping function on the barbed end of F-actin, resulting in promote fibroblast proliferation, migration, and differentiation. Further, histone deacetylase enzymes (HDACs) inhibitors and Co-IP demonstrated that HDAC8 is the desuccinylase for CAPZB in pulmonary fibrosis. Overexpressed HDAC8 desuccinylated CAPZB, led to abnormal F-actin polymerization and promoted pulmonary fibrosis. Finally, the therapeutic effect of succinylated CAPZB was confirmed in mice.
Conclusions
Collectively, our research revealed that HDAC8-mediated CAPZB desuccinylation promoted idiopathic pulmonary fibrosis by enhancing cytoskeleton remodeling, suggesting that desuccinylated CAPZB could be a potential therapeutic target related to cytoskeleton remodeling for pulmonary fibrosis.
Lqr-Fuzzy Logic Control of a Quarter Vehicle Model
Authors: Özgüney Ömür Can
Published: January 2025

In this study, a new control rule was developed using two different control methods, and the results were discussed by applying the developed controller to the quarter vehicle model. A new hybrid controller was designed by considering the advantages of Fuzzy Logic control method and Linear Quadratic Regulator (LQR) control method. Control gain coefficients used in LQR controller were determined by fuzzy logic control method. The developed new controller has been applied to the quarter vehicle model. In the results, control with only Fuzzy Logic controller and developed LQR-Fuzzy Logic controller were compared. It was understood from the results that the developed control method was satisfactory.
Evaluation of Sustainable Washing Processes for Fashionable Effects in Denim
Authors: Şevkan Macit Ayşe
Published: January 2025

Sustainability has become an important issue in every sector today. Effective use of resources is an issue that needs to be emphasized at the global level. Since denim washing processes consume a lot of water, energy, chemicals and time, sustainable processes in this area have gained importance. Various denim washing processes developed in terms of effective use of resources for sustainable methods are applied. Practices may be aimed at reducing water consumption, or may be related to more sustainable chemical consumption. In addition, situations where the process is shortened, waste is reduced or water free processes can come to the fore can also contribute to sustainability. The effects of sustainable processes on fabric properties should also be considered. In this study, denim fabrics with fashionable fading and bleaching effects by different methods were used. Abrasion resistance and bending rigidity properties of denim fabrics with effects obtained by conventional and sustainable methods were investigated comparatively. The results obtained show that among the sustainable processes in the study, there are preferable processes in terms of bending rigidty and abrasion resistance properties.
An Adaptive PI Controller Design for Current Control of Brushless DC Motor Drives
Authors: Arslanoğlu Ceyhun , Adıgüzel Fatih
Published: January 2025

Brushless direct current motor(BLDCM) are used to drive many systems in numerous fields. The control of BLDCM with basic drive techniques is required to obtain the desired output. Although basic drive techniques may be unsatisfactory in meeting these demands, they have found an invariable place for themselves due to their easy-to-use advantages. Due to these reasons, many researchers have focused on how innovative solutions are developed. In this paper, an adaptive PI controller is proposed to control the current of BLDCM drives. This paper aims to design a PI controller with time-varying gains for current regulation. The adaptive PI, improving the steady-state response, is constructed by one adaptation rule and a classical PI. In addition, the stability analysis is proved with Lyapunov theory. To demonstrate the effectiveness of the proposed controller, several simulations are performed with comparisons. The simulations with a classical PI and high-gain current controller comparisons are presented for set-point and sinusoidal references, and 500 rpm and 1500 rpm motor speeds. Comparing the classical PI with adaptive controller, the adaptive controller improves the current performance from 0.3442 to 0.0656 for 500 rpm, and from 0.4703 to 0.1552 for 1500 rpm in RMS of the current errors for 2A reference current. Similarly, the outcomes of comparing the high-gain controller to the adaptive PI show that the designed controller reduces RMS of the currents errors from 0.1853 to 0.1611 for 1500 rpm with 2A reference current, and from 0.1879 to 0.1720 for 1500 rpm with a sinusoidal reference current.
The Effect of Different Mixing and Compaction Temperatures on the Particle (Cantabro) Loss in Porous Asphalt Pavements
Authors: İbiş Ahmet Buğra , Sengoz Burak , Almusawi Ali , Kaya Özdemir Derya , Topal Ali
Published: January 2025

Porous asphalt (PA) is a type of pavement with an open-graded aggregate that contains higher air voids than the conventional asphalt pavements after compaction, which allows precipitation waters to infiltrate from the pavement surface to the lower layers. The particle loss in the wear layer causes surface deterioration, which affects pavement performance. In addition, the porosity nature of porous asphalt leaves the pavement under the effect of air and water continuously, which accelerates the oxidation rate and affects the surface properties of the pavement. Moreover, these factors can affect the bitumen-aggregate bond strength and cause cohesion degradation within the asphalt film, causing the bitumen to peel from aggregate. The performance of porous asphalt, particularly strength and durability, is greatly affected by compaction temperature. Higher compaction temperatures can reduce the air voids of the mix, so the required mix densities may not be achieved. In this study, the particle loss of porous asphalt samples prepared at 3 different compaction temperatures by using unmodified bitumen, SBS®, Elvaloy®, and Sasobit® modified bitumen was investigated and the optimum mixing and compaction temperature was determined.
Buğday Samanı ve Kenevir Lifi ile Üretilen Miselyum Biyokompozitleri
Authors: Mocan Merve , Akış Rukiye , Akgürsu Nurseda , Albayrak İlayda
Published: January 2025

Genleştirilmiş polistiren (EPS) köpük, dayanıklılığı, hafifliği ve uygun maliyeti nedeniyle sıklıkla tercih edilen bir ambalaj malzemesidir. Bununla birlikte düşük yoğunluğu, geri dönüşümünün ekonomik sebeplerle tercih edilmemesine yol açmakta ve doğada bozunmayan yapısı nedeniyle çevrede yüksek miktarda plastik kirliliğine sebep olmaktadır. Bundan dolayı, birçok ülke EPS ambalaj ürünlerini yasaklamaya başlamıştır. Çevresel etkiyi azaltmak için EPS'nin biyo-esaslı ve biyobozunur alternatiflerle değiştirilmesi gerekmektedir. Miselyum esaslı malzemeler tamamen biyo-esaslı ve biyobozunur oldukları için, boyutsal kararlılığa sahip köpüğümsü yapısı ile EPS ambalaj için güçlü bir aday olarak sunulabilirler. Ancak, malzeme özelliklerinin halen geliştirilmesi gerekmektedir. Besiyeri olarak kullanılan doğal liflerin türü ve boyutu değiştirilerek, miselyum esaslı biyokompozitlerin son ürün özellikleri ayarlanabilir ve geliştirilebilir. Bu çalışmada, Pleurotus ostreatus miselyumu, kenevir lifi ve buğday samanı kullanılarak tamamen biyo-esaslı ve biyobozunur biyokompozit köpük ürünleri üretilmiştir. Bu doğal liflerin türünü ve boyutunu değiştirerek elde edilen biyokompozitlerin özellikleri incelenmiştir. Pleurotus ostreatus miselyumuna kenevir lifi ve buğday samanının ayrı ayrı ve birlikte ve farklı boyutlarda katılması ile malzemelerin yapısal, mekanik, ısıl, morfolojik, su emme ve yanıcılık özelliklerine etkisi ilk kez karakterize edilmiş olup besiyer çeşidine göre basma dayanımı 21-30 kPa, su emme %147-348 arasında değişmiş, 234-552 °C’ye kadar sıcaklık dayanımı göstermiş, 90 saniyeye kadar süren yanma testinde kenevir içeren numunelerde tutuşma görülmemiş olup kenevir ve buğday samanının birlikte kullanılması ürün özelliklerinin geliştirilmesinde sinerjistik etki tespit edilmiştir. Miselyum esaslı biyokompozitlerin petrol esaslı ve doğada bozunmayan polimerlere sürdürülebilir bir alternatif olarak güçlü bir potansiyel taşıdığı gösterilmiştir.
Çevre Dostu Manyetik Pektin Nanobiyokompozitleri Kullanarak Toryum(IV) İyonlarının Giderilmesi
Authors: Yusan Sabriye , Özçivit Çağkan , Kaptanoğlu İkbal Gözde
Published: January 2025

Bu çalışmada, sucul ortamlardan toryumun uzaklaştırılması için etkili, güvenli, çevre dostu ve toksik olmayan pektin-manyetik (Fe3O4) nanobiyokompozitler birlikte çöktürme yöntemiyle sentezlenmiş ve karakterize edilmiştir. Optimum özelliklere sahip manyetik nanobiyokompozit adsorban ile toryumun sulu çözeltilerden uzaklaştırılması için, pH, toryum konsantrasyonu, sıcaklık ve temas süresi gibi ana deneysel parametrelerin etkisi kesikli yöntemlerle incelenmiştir. Langmuir, Freundlich ve Dubinin-Radushkevich izotermleri kullanılarak adsorpsiyon modeli belirlenmiş ve ilgili parametreler hesaplanmıştır. Ayrıca, adsorpsiyonun termodinamik parametreleri olan entalpi, Gibbs serbest enerji değişimi ve entropi hesaplanmıştır.
Bethe $M$-layer construction for the percolation problem
Authors: Angelini Maria Chiara , Palazzi Saverio , Rizzo Tommaso , Tarzia Marco
Published: January 2025

One way to perform field theory computations for the bond percolation problem is through the Kasteleyn and Fortuin mapping to the n+1n+1 states Potts model in the limit of n \to 0n→0. In this paper, we show that it is possible to recover the \epsilonϵ-expansion for critical exponents in finite dimension directly using the MM-layer expansion, without the need to perform any analytical continuation. Moreover, we also show explicitly that the critical exponents for site and bond percolation are the same. This computation provides a reference for applications of the MM-layer method to systems where the underlying field theory is unknown or disputed.
Factors influencing organizational citizenship behavior among employees: Evidence from the commercial banking industry
Authors: Rahman Tanchi Khadiza , Bin Amin Mohammad , Khatun Swapna , Mobarak Karim Md. , Erdey László
Published: January 2025

This study aims to investigate the relationship between organizational commitment, training perception, organizational support, and organizational citizenship behavior within the banking sector. Data were gathered from 250 employees of commercial banks in Dhaka, Bangladesh, utilizing an online survey questionnaire. This quantitative and exploratory study ultimately analyzed a final sample of 200 participants, using a convenience sampling method. A five-point Likert scale was applied to assess replies, with “1” signifying “Strongly Disagree” and “5” signifying “Strongly Agree.” SPSS was applied to test the research model. A positive and significant relationship was revealed between organizational commitment, perception of training, organizational support, and citizenship behavior. Based on these findings, bank management should leverage organizational commitment, perceived training, and perceived organizational support to enhance citizenship behavior among employees, thereby improving overall bank performance. The perceived training (β = 0.287; p < 0.05) had the highest effect on organizational citizenship behavior, while organizational commitment (β = 0.275; p < 0.05) had the lowest effect on organizational citizenship behavior. Specifically, the standardized beta coefficient for perceived training suggests that improvements in employee perceptions of training are associated with notable increases in organizational citizenship behavior, making it the most influential factor in this analysis. In comparison, organizational commitment, with a lower beta coefficient also positively affects organizational citizenship behavior, but to a lesser degree than perceived training. The results of this study are advantageous for the banking industry and strategists seeking to promote organizational citizenship behavior among their employees.
A presença da Marinha brasileira na amazônia: do Pós-Guerra Fria aos anos iniciais do século XXI
Authors: Roberto Pivatto Junior Dilceu
Published: January 2025

O artigo consiste em compreender a Amazônia no pensamento da Marinha do Brasil, de modo que se identifique os debates internos da força, as prioridades estabelecidas e as suas atribuições para a defesa da região amazônica. Para tal finalidade, procurou-se analisar a presença da Marinha brasileira na região amazônica, por meio: da crescente prestação de suporte logístico e da criação do 9º Distrito Naval; e do correspondente aprestamento das forças de emprego fluvial, incluindo as Operações Ribeirinhas. A metodologia empregada na pesquisa deste artigo foi qualitativa e de análise documental, do período correspondente aos anos de 1992 a 2008. Fontes consultadas: documentos do Ministério da Marinha e do Ministério da Defesa; monografias dos cursos da Escola de Guerra Naval; periódicos profissionais militares; livros de autores militares da Marinha; e entrevistas com ex-Ministros e ex-Comandantes da Marinha do Brasil. A análise destas diferentes fontes possibilitou a identificação das linhas de pensamento predominantes e que, consequentemente, influenciaram na formulação da estratégia da Marinha do Brasil para a defesa da Amazônia.
Strategy for Resolving Gender Conflict in the Household for Women Industrial Workers
Authors: Inderasari Elen , Giyoto Giyoto
Published: January 2025

Poverty forced most females to have double roles as housewives and workers. It happened to help the husbands look for a good living. This research aimed to describe the strategies for female industrial workers in Surakarta to resolve gender conflict in a household. This research used qualitative method to describe the data retrieved by interview technique using social role theory to find out the existence of double role conflict, kinds of conflicts, and strategies in resolution of the gender role conflict from the respondents in the regions of Surakarta, Boyolali, Sragen, Wonogiri, and Sukoharjo by referring to the patterned social behavior, social identity, and shared social expectations. This research uncovered the existence of various conflicts among female workers i.e. working hours, household chores, relationship communication between husband and wife (biological relationship), and childcare. Furthermore, this research also found the strategies used by housewives in facing conflicts, including division of role as head of the family, division of working hours, parenting arrangement, family biological time arrangement, and social community. Regarding the findings, this research provided female industrial workers with several alternative solutions to help them divide their time for professionally working in domestic and public affairs.
Gender Equality in Islamic Marriage Law through the Maqāṣid al-Sharī’a Perspective: A Study on Woman-initiated Divorce (Cerai Gugat) in Indonesia
Authors: Mufti Muhammad
Published: January 2025

The presence of gender equality issues in Islamic family law has already become a new challenge faced by Muslims to manifest and uphold the higher purpose of sharī’a (maqāṣid al-sharī’a). Thus, maqāṣid al-sharī’a as a theoretical framework should be able to accept adjustment depending on the circumstance. This article aims to discuss the notion of gender equality in maqāṣid al-sharī’ah perspective, which is focused on two research questions, namely what is the perspective of maqāṣid al-sharī’a on gender equality discourse, especially in Islamic marriage law, and how can the reform of Islamic marriage law in the practice of divorce support the realization of a new paradigm of maqāṣid al-sharī’a to achieve justice. Using woman-initiated divorce (cerai gugat) in recent Indonesia as a case study and incorporating a normative legal approach along with the Islamic feminism theory proposed by Amina Wadud, the article concludes that the maqāṣid al-sharī’a applied in the Muslim legal tradition demonstrates the flexibility of Islamic law in adapting to various demands and circumstances. In the context of Islamic family law in Indonesia, it can be proven by the presence of woman-initiated divorce (cerai gugat) which has never been done before. It became a manifestation of the ability of maqāṣid al-sharī’a to reconcile contemporary issues such as the notion of gender equality.
Research on mechanical part recognition method based on improved mask R-CNN instance segmentation
Authors: Xiao Kui , Wang Lei , Xu Haoran , Zhang Pengchao , Zhang Heng
Published: January 2025

Aiming at the problem of poor part recognition due to mutual occlusion between parts and the influence of different postures in the assembly scene, we propose an improved Mask R-CNN-based part recognition method for complex scenes. Firstly, the ResNet101 network is used to enhance the feature extraction capability of the network and improve the part recognition effect; secondly, the normalization layer of the backbone network is replaced to reduce the effect of batch size on the feature extraction of the model; lastly, the feature pyramid network structure is improved to enhance the transfer efficiency between the high and low layers of the network, and to enhance the capability of the feature capture; through the experiments on the homemade dataset, the average detection accuracy of this method is 4.7 % higher than that of the original Mask R-CNN. Through the experiments on the homemade dataset, it is found that compared with the original Mask R-CNN, the average detection accuracy of the method is improved by 4.7 %.The optimized network model proposed in this paper can improve the accuracy of part recognition, realize the accurate detection of parts in the complex environment such as stacking, occlusion and so on, and provide a solution for the recognition of parts in the complex environment.
Caracterização de filmes à base de alginato de sódio e cloreto de cálcio e sua utilização na composição de coberturas comestíveis de queijo coalho
Authors:   , Macedo Renata Cristina Borges da Silva
Published: January 2025

A utilização de plásticos biodegradáveis para a elaboração de embalagens de alimentos tem se tornado uma tendência cada vez mais abordada no meio científico, tendo em vista diversos benefícios ambientais associados ao uso destas. Assim, a utilização de coberturas comestíveis de alginato de sódio em queijo de coalho surge como uma alternativa promissora na conservação deste produto, uma vez que a falta de padronização das boas práticas de fabricação junto às particularidades do produto faz deste um alimento de extrema perecibilidade. Os principais métodos de conservação de queijo coalho estão associados à utilização de polímeros sintéticos não biodegradáveis, acarretando em sérios problemas ambientais. Com o intuito de aumentar a vida de prateleira do queijo coalho utilizando-se de embalagens ecologicamente corretas, tem-se por objetivo avaliar a influência de filmes e coberturas comestíveis à base de alginato de sódio na conservação e vida de prateleira deste produto. Os filmes foram elaborados e caracterizados, com posterior aplicação em forma de cobertura comestível ao queijo coalho, avaliando-se os tratamentos (CO, 3AS, 3AC, 4AS, 4AC) em intervalos de três a nove dias de análise. Foram realizadas avaliações físico-químicas e microbiológicas. O delineamento experimental foi feito de forma inteiramente casualizada com cinco repetições e as avaliações microbiológicas e físico-químicas foram analisadas com o teste de análise de variância (ANOVA) e o teste de Tukey ao nível de 5% de significância. Com os testes de caracterização das coberturas comestíveis pôde-se observar que os resultados mostraram semelhança significativa em relação ao controle quanto à luminosidade e estatisticamente diferentes para os parâmetros de espessura, permeabilidade ao vapor de água (PVA), cromaticidade a*, cromaticidade b* e opacidade. Coberturas comestíveis foram eficientes na conservação da perda de massa do queijo coalho aos nove dias de armazenamento refrigerado. Não foram observadas diferenças significativas para as análises de pH, acidez, cromaticidade a* e cromaticidade b*. A luminosidade apresentou diferença significativa para as coberturas 3AC e 4AC, diminuindo a incidência de luz nos queijos. Bolores e leveduras e bactérias aeróbias mesófilas não foram afetados pela aplicação das coberturas comestíveis. Coberturas comestíveis de alginato de sódio se mostraram promissoras na manutenção dos padrões qualitativos do queijo coalho durante nove dias de armazenamento refrigerado.