bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR-FAKTOR YANG MEMPENGARUHI AUDIT REPORT LAG
Authors: Yuliastina Mellani , Rahmah Siti Aulia Nur , Nor Wahyudin , Lesmanawati Dewi
Published: March 2024

The intense competition within the capital market has prompted companies going public to enhance the caliber of their financial statements and hasten the release of audited financial reports. The purpose of this research is to evaluate and scrutinize the influence of factors such as audit tenure, corporate governance as measured by the presence of an independent board of commissioners, institutional ownership and managerial ownership, financial hardship, and audit capacity pressure on the delay of audit reports. The research population is comprised of infrastructure, utility, and transportation companies that were registered on the IDX during 2016-2019. Employing purposive sampling techniques, a sample of 21 companies was selected. The outcomes of the research indicate that audit tenure, institutional ownership, and financial difficulty have an impact on the delay of audit reports, while the existence of independent commissioners, managerial ownership, and audit capacity pressure do not have any effect on the delay of audit reports.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI CUSTOMER LOYALTY PENGGUNA PAY LATER DENGAN MEDIASI CUSTOMER SATISFACTION PADA MASYARAKAT PROVINSI KEPULAUAN RIAU
Authors: Sherina Sherina , Edy Yulianto Putra
Published: March 2024

ABSTRACT
Pay Later is a credit payment method facility, which is buy now and pay later. With the convenience and advantages that can be obtained from Pay Later services to consumers, many Indonesian companies see the potential for develop and also participate in competing in the BNPL (Buy Now Pay Later) industry. Reviewed from the number of companies that provide Pay Later facilities with various features,its quite challenging in this industry. In order to remain competitive in the market, apart from prospect to new customers, companies must also maintain customer loyalty. Because of that, this study was implemented for knowing the variable that influence customer loyalty in Pay Later through  Brand Image, Trust, Experience Quality, Service Quality, Corporate Social Responsibility with the mediation of Customer Satisfaction. This analysis using Smart PLS 3 software for statistical result and SPSS for descriptive analysis result.The study was conducted on 468 respondents of Pay Later users in the Riau Islands Province. This study proven that Trust, Brand Image and Customer Satisfaction had positive and significant results in encouraging customer loyalty of PayLater users.
ABSTRAK
Pay Later adalah sebuah fasilitas metode pembayaran secara kredit. Artinya, membeli sekarang dan membayarnya kemudian. Dengan kemudahan dan keunggulan yang dapat diperoleh dari layanan Pay Later kepada konsumen, banyak perusahaan Indonesia yang melihat potensi perkembangan dan juga ikut berpartisipasi untuk bersaing di industri BNPL (Buy Now Pay Later). Ditinjau dari banyaknya perusahaan yang menyediakan fasilitas Pay Later dengan berbagai fitur-fiturnya, tidak mudah bagi perusahaan untuk memperoleh pangsa pasar yang baik, untuk dapat tetap bersaing di pasar tersebut, selain dari melakukan pemasaran kepada pelanggan baru, perusahaan juga harus mempertahankan loyalitas dari pelanggan. Oleh sebab itu, studi ni diterapkan untuk mengetahui variabel yang berpengaruh terhadap kesetiaan pelanggan Pay Later melalui variabel Brand Image, Trust, Experience Quality, Service Quality, Corporate Social Responsibility dengan mediasi Customer Satisfaction. Analisis ini menggunakan perangkat lunak Smart PLS 3 untuk pengujian statistik dan SPSS untuk pengujian analisis deskriptif. Penelitian dilakukan kepada 468 responden pengguna Pay Later di Provinsi Kepulauan Riau. Hasil penelitian menunjukkan bahwa  Brand Image, Customer Satisfaction dan Trust memiliki hasil yang positif dan signifikan dalam mendorong loyalitas pelanggan pengguna PayLater.
PENGARUH INCOME LEVEL DAN EDUCATION LEVEL TER-HADAP BEHAVIORAL INTENTION TO OWN CREDIT CARD DENGAN DIMEDIASI PERCEIVED FINANCIAL COST DAN PER-CEIVED SELF EFFICACY PADA BANK BCA DI SURABAYA
Authors: Prathama Gibson , Harsono Soni
Published: March 2024

Credit cards are becoming a trend among the people of Surabaya to have them with vari-ous consequences that must be accepted. Even its use has increased post-covid-19. Of course, individuals who had it had to consider their income and qualified knowledge regarding credit cards. This study seeked to reveal the role of income level and education level on behavioral intention to own a credit card of BCA in Surabaya mediated by per-ceived financial cost and perceived self-efficacy using a quantitative method using Struc-tural Equation Modeling (SEM) with a total sample of 190 respondents from customers who own credit cards of BCA Bank in Surabaya. The results showed that income level and education level had an effect on perceived financial cost. Income level, education level, perceived financial cost, and perceived self-efficacy had an effect on behavioral intention to own. Income level and education level had an effect on behavioral intention to own through perceived financial cost, and income level and education level influenced behavioral intention to own through perceived self-efficacy. Suggestions for research need to broaden the scope was not only in Surabaya and the Bank needed to pay attention to income levels and customers' understanding of BCA credit cards.
DAMPAK INOVATION CAPABILITY TERHADAP COFFEE SHOPS COMPETITIVENESS DI KOTA BANJARMASIN
Authors: Gea Hiqori Sonia  , Zakhyadi Ariffin  , Editor Admin
Published: March 2024

Coffee shops are a trending business in Indonesia, including in the city of Banjarmasin. Although many coffee shops have been established, however many coffe shops have failed. Competitiveness determines the success of a coffee shop in intensive competition.  Purpose. The purpose of this study was to investigate the effect of market orientation and entrepreneurial orientation on competitiveness mediated by organizational innovation.Methods The research was conducted on the coffee shop industry in the city of Banjarmasin which is not a franchise. Questionnaires were sent to 50 coffee shops registered with the Banjarmasin city government. A total of 40 coffee shop managers answered the questionnaire. Data analysis uses partial least squares (PLS). Result. The results of the study show that market orientation and entrepreneurial orientation have a direct effect on competitiveness. Organizational innovation can mediate the effect of market orientation and entrepreneurial orientation on competitiveness
Role of vitamin D in the prevention of acute respiratory infections: a systematic review and meta-analysis
Authors:   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Gorelov A.V. ,   A.I.Yevdokimov Moscow State University of Medicine and Dentistry, Moscow, Russian Federation,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Petrov V.A. ,   A.F.Tsyb Medical Radiology Research Center, Obninsk, Russian Federation, Usenko D.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation
Published: March 2024

Reducing the risk of acute respiratory infections (ARIs) through vitamin D administration is a common preventive strategy used in routine clinical practice. However, the results of clinical trials are often controversial, which makes it necessary to summarize data available so far in order to develop more clear and well-founded clinical guidelines. Materials and methods. This meta-analysis was conducted to summarize the evidence on the preventive efficacy of vitamin D3 (cholecalciferol) against ARIs among adults using the results of randomized clinical trials (RCTs). The primary endpoint in all included studies was the absolute proportion of participants diagnosed with at least one ARI episode (upper/lower respiratory tract infections or infections of mixed locations) during the follow-up period. Results. We found that vitamin D3 intake (n = 11,276) was effective for preventing ARIs vs placebo (n = 10,955): in a random effects model, the odds ratio (OR) was 0.82 (95% confidence interval (CI): 0.69–0.98; p = 0.0355), whereas the number needed to treat (NNT) was 20.43 (between 10.70 and 255.67). There were no differences in efficacy between daily, weekly, or monthly intake of vitamin D3 (p = 0.7884). Given that 7 out of 13 studies included in this meta-analysis analyzed daily vitamin D3 intake and only 1 study assessed weekly intake, we can conclude that daily dosing, in general, has a broader evidence base. Conclusion. Thus, daily intake of D3 at a dose of ≥ 2000 IU/day (NNT = 20.43) was the most effective and studied strategy for preventing ARIs among adults. Key words: acute respiratory viral infections, influenza, COVID-19, nonspecific prevention, vitamin D3, colecalciferol
Concomitant hemorrhagic fever with renal syndrome and COVID-19
Authors:   Izhevsk State Medical Academy, Izhevsk, Russian Federation, Sarksyan D.S. , Kilin D.A. ,   Izhevsk State Medical Academy, Izhevsk, Russian Federation, Dudarev M.V. ,   Izhevsk State Medical Academy, Izhevsk, Russian Federation, Manakhov K.M. ,   Izhevsk State Medical Academy, Izhevsk, Russian Federation, Anikaev V.P. ,   Republican Clinical Hospital for Infectious Diseases, Ministry of Public Health of the Udmurt Republic, Izhevsk, Russian Federation, Atamanova A.A. ,   Republican Clinical Hospital for Infectious Diseases, Ministry of Public Health of the Udmurt Republic, Izhevsk, Russian Federation, Maleev V.V. ,   Central Research Institute of Epidemiology of The Federal Service on Customers' Rights Protection and Human Well-being Surveillance, Moscow, Russian Federation
Published: March 2024

Udmurt Republic is an endemic region for hemorrhagic fever with renal syndrome (HFRS). An extremely high incidence of COVID-19 in 2020-2021 worldwide and in Udmurt Republic in particular suggests that patients might bear these two infections simultaneously. In this article, we report a case of mixed COVID-19 plus HFRS infection. Specific clinical manifestations of HFRS in a COVID-19-coinfected patient included long-term fatigue, thrombocytopenia, iso(hypo)sthenuria, polyuria, episodes of sinus tachycardia and hypertension. On the other hand, the main clinical characteristics of COVID-19 in a HFRS-coinfected patient included no clinical signs of respiratory failure and relatively high saturation despite a substantial lung damage. In general, mixed infection is a risk factor that aggravates the disease and can worsen outcome. However, simultaneous infection of a cell with more than one virus probably causes viral interference, which results in suppression of one or both viruses. Key words: COVID-19, hemorrhagic fever with renal syndrome, viral interference
Algorithm for managing outpatients with COVID-19 infection
Authors:   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Sharavina Yu.A. ,   Treatment and Rehabilitation Center of the Main Center for Supporting the Activities of the National Guard Troops of the Russian Federation, Moscow, Russian Federation, Nikolaeva S.V. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Pestova A.N. ,   Treatment and Rehabilitation Center of the Main Center for Supporting the Activities of the National Guard Troops of the Russian Federation, Moscow, Russian Federation, Ponezheva Zh.B. ,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation
Published: March 2024

Oblective. Optimisation of managing patients with COVID-19 in outpatient department based on clinical, laboratory, instrumental features of the disease in different periods of the pandemic. Patients and methods. A retrospective analysis of medical records of 400 COVID-19 patients aged 21 to 59 years (200 people during the period of maximum circulation of the variant "Delta" and 200 people during the period of maximum circulation of "Omicron"). There are 2 groups – 100 patients are in group 1 (21–44 years, average age 36.6 years) and 100 patients are in group 2 (45–59 years, average age 48.4 years). In all cases, the basis for the examination was the presence of symptoms of acute respiratory infection (ARI) and detection of SARS-CoV-2 in the study of a smear from nasopharynx and oropharynx by PCR. The modern statistical methods were used for data processing, relative and absolute indicators were evaluated. Results. In comparative analysis of clinical symptoms depending on the variant in COVID-19, significant differences were found in frequency of shortness of breath, heavy breathing , cough, myalgia, taste and smell loss, fatigue in patients with COVID-19 delta variant. Also COVID-19 Delta variant was statistically more severe compared to Omicron variant. Statistically more often patients suffer from sore throat during the circulation of "Omicron" variant. Leukopenia, monocytosis and high ESR have been observed in patients with COVID-19 delta variant. Conclusion. Outpatients with clinical manifestations of respiratory infection in epidemic season should conduct laboratory differential diagnosis of SARS-CoV-2 by PCR, blood test, including biochemical profile and coagulation test. In case of positive test , the further tactics of patient management depend on the form of disease ( mild forms – outpatient observation, severe forms -inpatient observation, in moderate forms for the management of patient , it is necessary to pay attention to the presence of comorbid pathology). Key words: COVID-19, genovariant, Delta, Omicron, outpatients
Efficacy of Remaxol in COVID-19 patients receiving antiviral therapy
Authors:   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Shuldyakov А.А. , Lyapina E.Р. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Smagina A.N. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Lisko O.B. ,   V.I.Razumovsky Saratov State Medical University, Saratov, Russian Federation, Kovalenko A.L. ,   S.N.Golikov Research and Clinical Center of Toxicology, Federal Medical Biological Agency, Saint Petersburg, Russian Federation, Kozorez E.I. ,   Gomel State Medical University, Gomel, Belarus
Published: March 2024

Management of COVID-19 patients with drug-induced liver lesions requires a comprehensive approach to treatment with correction of metabolic disorders and prevention of adverse events. We describe our experience with using Remaxol, a drug with hepatoprotective, antihypoxic, antioxidant, and cytoprotective effects. It is applied for hepatotropic support in COVID-19 patients receiving antiviral therapy. Intravenous infusions with Remaxol (400 mL) in comprehensive treatment of COVID-19 patients promoted normalization of liver function tests, which made it possible to continue antiviral therapy without dose correction and interruptions. Remaxol was well tolerated and caused no side effects; none of the patients required its cessation. Key words: hepatotoxicity, hepatoprotectors, Remaxol, COVID-19
Age structure of patients with COVID-19 in epidemic dynamics of novel coronavirus infection in the Rostov Region
Authors:   Rostov Scientific Research Institute of Microbiology and Parasitology of Rospotrebnadzor, Rostov-on-Don, Russian Federation, Tverdokhlebova T.I. ,   Rostov State Medical University, Rostov-on-Don, Russian Federation, Suladze A.G. ,   Rostov Scientific Research Institute of Microbiology and Parasitology of Rospotrebnadzor, Rostov-on-Don, Russian Federation, Ryndich A.A. ,   Rostov Scientific Research Institute of Microbiology and Parasitology of Rospotrebnadzor, Rostov-on-Don, Russian Federation, Matuzkova A.N. ,   Rostov Scientific Research Institute of Microbiology and Parasitology of Rospotrebnadzor, Rostov-on-Don, Russian Federation, Dontsov D.V. ,   Rostov State Medical University, Rostov-on-Don, Russian Federation, Logvin F.V. ,   Rostov State Medical University, Rostov-on-Don, Russian Federation
Published: March 2024

Objective. To study the features of the age structure of patients with COVID-19 in the Rostov Region in different periods of the pandemic. Materials and methods. A retrospective and current epidemiological analysis of the incidence of COVID-19 in the Rostov Region between March 2020 and April 2022 was performed. The analysis was conducted for the age groups of “0–17”, “18–45”, “46–65”, and “over 65” years in different pandemic periods. Results. The epidemic process of novel coronavirus infection in the Rostov Region during the observation period was characterized by a wavy course with recurrent disease rises and falls. Five time periods of the pandemic were recorded. Some features of the age composition of COVID-19 patients in different periods were revealed: a 2-fold increase in the proportion of children by the 5th period (up to 14.2%) and an increase in the involvement of people over 65 years in the 2nd and 4th periods (25.9% and 19.6%, respectively). The main force behind the pandemic were individuals aged 18–65 years. Conclusion. The age structure of COVID-19 patients during the observation period (two years and a half) was characterized by the predominance of adult patients over 18 years of age. The proportion of children at the beginning of the COVID-19 pandemic was low, but as the epidemic process evolved, the role of this age group increased significantly. The increase in the incidence among children can probably be explained by the emergence of new SARS-CoV-2 genovariants, which are highly contagious and virulent. Key words: COVID-19, monitoring, epidemic process, SARS-CoV-2, age structure
Outbreak of parvovirus infection B19 in children in the Republic of Sakha (Yakutia)
Authors:   Departments of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Republic of Sakha, Yakutia, Russian Federation, Ignatyeva M.E. , Samoylova I.Yu. ,   Departments of the Federal Service for Supervision of Consumer Rights Protection and Human Welfare in the Republic of Sakha, Yakutia, Russian Federation, Pshenichnaya N.Yu. ,   Central Research Institute of Epidemiology Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Gopatsa G.V. ,   Central Research Institute of Epidemiology Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Ploskireva А.А. ,   Central Research Institute of Epidemiology Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Amirov R.S. ,   Central Research Institute of Epidemiology Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation, Akimkin V.G. ,   Central Research Institute of Epidemiology Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation
Published: March 2024

Parvovirus infection B19 is widespread all over the world and causes a wide range of clinical manifestations, ranging from a mild course of the disease with manifestations of infectious erythema in immunocompetent patients, severe cytopenia in immunocompromised patients and causing difficulties in diagnosis. Objective. To present the description of an outbreak of parvovirus infection with the atypical duration in children in the Republic of Sakha (Yakutia). Results. Since April 10, 2023, 47 cases of parvovirus infection have been registered in the Republic of Sakha (Yakutia) in children aged 8–17 from an educational institution of around-the-clock stay. Considering that clinically the disease in 100% of cases was characterized only by the presence of exanthema without fever and symptoms of intoxication, in the first cases the symptoms of the disease were regarded as manifestations of allergic dermatitis. After an increase in the number of cases, differential diagnosis was carried out between measles, rubella and enterovirus infection. And only at the stage of obtaining negative results for these diseases, parvovirus infection was included in the examination plan. The diagnosis of "parvovirus infection" was confirmed in the laboratory by the detection of parvovirus B19 DNA in oropharyngeal smears, as well as by the serology test of blood serum with the detection of IgM to parvovirus B19. Conclusion. Given the variety of clinical manifestations of parvovirus infection, it is necessary to increase the alertness of specialists regarding the features of clinical manifestations of infection and its early diagnosis. Key words: parvovirus infection, outbreak, children
Badak Jawa Dalam Karya Patung Deformasi
Authors: Setiawan Hilman , Tridjata Caecilia
Published: March 2024

Indonesia memiliki keragaman hewan endemik yang populasinya telah terancam kepunahannya. Salah satunya hewan Badak Jawa. Di Indonesia hewan ini hanya dapat di temui di Taman Nasional Ujung Kulon Banten. Populasi badak Jawa atau Badak bercula satu hanya terdapat 60-67 ekor saja hal tersebut sangat memperhatinkan sehingga penulis bersimpati dan tertarik untuk menciptakan sebuah karya patung deformatif bertemakan badak Jawa kedalam tugas akhir. Deformasi badak Jawa. Pemilihan konsep berdasarkan pertimbangan bahwa keunikan badak Jawa memiliki cula satu yang secara faktual belum banyak di ketahui oleh masyarakat luas. Visualisasi karya ini memiliki visual patung dengan interes seni reflektif, interes bentuk abstraktif, dan memiliki prinsip estetika seni modern. Replika patung badak Jawa di buat dengan deformasi. Deformasi karya badak Jawa terletak pada ukuran tubuh karya, volume tubuh karya dan struktur bentuk karya. Deformasi tersebut sebagai bentuk penggambaran imajinasi perupa. Penciptaan karya patung di buat dengan berbagai macam teknik yaitu teknik Teknik kontruksi, Teknik assembling, Welding/Las pada setiap karya. Karya tugas akhir ini diharapkan dapat bermanfaat bagi masyarakat yang mengapresiasi karya patung dan bentuk tanggung jawab perupa sebagai masyarakat Banten, tidak hanya sebagai sebagai pendidik seni rupa.
Analisis Seni Gambar Kaligrafi Santri Madrasah Aliyah Kelas XI Usia 16-17 Tahun di Pesantren Al Aulia Bogor Barat
Authors: Putri Safira , Oetopo R.A Ataswarin
Published: March 2024

Tujuan penelitian ini adalah menganalisis seni gambar kaligrafi, serta untuk menemukan makna dari setiap ayat Al-Qur'an dalam karya dan implementasinya. Hal itu berdasarkan latar belakang fakta bahwa Faktor dalam menggambar kaligrafi lebih mendukung kegiatan baca tulis Qur’an atau dapat mendukung program tahfiz Qur’an serta dapat menjadi bahan dalam berdakwah, meningkatkan karakteristik anak santri/santriawati menjadi lebih baik yang berpedoman pada kitab Al-Qur’an. Teori yang digunakan untuk penelitian ini di antaranya adalah teori menurut Nasir tentang definisi lembaga keagamaan, teori menurut Hakim tentang model pendidikan pesantren, Victor Lownfeld tentang “Creativity and Mental Growth”, masa perkembangan seni rupa pada usia 16-17 tahun, teori Al-Faruqi membahas tentang bacaan Al-Qur’an dan khat, serta teori Susanto tentang definisi kaligrafi. Adapun metode yang digunakan adalah penelitian deskriptif pendekatan kualitatif. Jenis analisis yang digunakan yaitu analisis formalistik menggunakan teori menurut Aliakbari dan Hatami tentang "The Role of Calligraphy in Islamic Art and Its Interpretation", serta analisis konten menggunakan teori menurut Stokstad dan Cothren  serta teori dari Sheila S. Blair dan Jonathan M. Bloom. Hasil dari penelitian ini terdapat beberapa karya santri yang masih pemula dalam teknik membuat dekorasi gambar kaligrafi. Faktor penghambat pelaksanaan ekstrakurikuler kaligrafi Al-Qur'an di Pondok Pesantren Al-Aulia adalah keterbatasan waktu dengan kegiatan pesantren lainnya. Adapun faktor pendukungnya adalah Santri, Pembina Pondok Pesantren, Pembimbing Ekstrakurikuler. Rekomendasinya adalah pentingnya dalam meningkatkan dan mengoptimalkan kreativitas santri. Bagi pembimbing ekstrakulikuler kaligrafi diharapkan memanfaatkan media teknologi, agar santri lebih cepat dalam perkembangan ilmu kaligrafinya serta menjadikan referensi untuk penelitian selanjutnya yang berhubungan dengan analisis seni gambar kaligrafi pada santri.
“Digital turn” in legal research
Authors: Begishev I. R. , Zharova A. K. , Gromova E. A. , Zaloilo M. V. , Filipova I. A. , Shutova A.  A.
Published: March 2024

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Is Race an Independent Predictor of 5-Year Survival in Patients with Primary Malignant Bone Tumors?
Authors: Chan Justin M. , Cantor Nicole , Evans Daniel R. , Brigman Brian E. , Visgauss Julia D. , Eward William C.
Published: March 2024

Background
In the United States, socioeconomic status (SES), race, and ethnicity are factors used to predict adverse outcomes in various carcinomas as well as in soft tissue sarcoma. However, existing evidence is unclear if race is an independent predictor of overall survival in common primary malignant bone tumors, including Ewing sarcoma, osteosarcoma, and chondrosarcoma.
Methods
This is a retrospective analysis of the National Cancer Database (NCDB) of patients diagnosed with primary Ewing sarcoma, osteosarcoma, and chondrosarcoma between 1998 and 2016. Race/ethnicity was divided into White, Black, Asian, and “Hispanic”. Baseline and treatment characteristics between groups were compared using Pearson’s chi-square test for categorical variables and analysis of variance (ANOVA) for continuous variables. Long-term survival for each group was evaluated with the Kaplan-Meier (KM) method with comparisons between races based on the log-rank test. A multivariable Cox proportional hazard model was used to predict variables associated with lower overall survival.
Results
Black Ewing sarcoma patients had significantly poorer overall survival than did White, Asian, or Hispanic patients (p < 0.001) with a KM 5-year survival of 48.2% vs 61.0% vs 68.3% vs 63.0%, respectively, and a 123.5% (HR: 2.235, p = 0.009) higher independent likelihood of mortality in a multivariate analysis. Independent predictors of overall survival for Ewing sarcoma, osteosarcoma, and chondrosarcoma included older age (HR: 1.029, p < 0.001; HR: 1.020, p < 0.001; HR: 1.034, p < 0.001), more advanced cancer stage (HR: 3.315, p < 0.001; HR: 6.167, p < 0.001; HR: 10.201, p < 0.001), and positive surgical margins (HR: 1.679, p = 0.001; HR: 1.540, p < 0.001; HR: 1.992, p < 0.001), respectively. A significant racial disparity in survival for Black patients with Ewing sarcoma was identified.
Conclusions
Our study identifies a significant racial disparity in survival for Black patients with Ewing sarcoma. Our study reinforces previously established literature about predictors of overall mortality for Ewing sarcoma, osteosarcoma, and chondrosarcoma populations, while also providing new insight into the role of race, cancer-specific factors and treatment, and SES on long-term survival.
Predominance of the recombinant SARS-CoV-2 lineages XBB in Rio Grande do Sul State, Brazil: a genomic surveillance study and impact on vaccine response
Authors: Piccoli Bruna Candia , Castro Thais Regina y , Tessele Luíza Funck , Casarin Bruna Campestrini , Seerig Ana Paula , Vieira Andressa Almeida , Santos Vitor Teles , Schwarzbold Alexandre Vargas , Trindade Priscila Arruda
Published: March 2024

Purpose The COVID-19 pandemic has been marked by novel viral variants, posing challenges to global public health. Recombination, a viral evolution tool, is implicated in SARS-CoV-2's ongoing evolution. The XBB recombinant lineage, known for evading antibody-mediated immunity, exhibits higher transmissibility without increased disease severity. We investigated the prevalence and genomic features of XBB in SARS-CoV-2-positive cases in Rio Grande do Sul (RS), Brazil.
Methods We sequenced 357 samples from epidemiological weeks (EW) 47/2022 to 17/2023, and included 389 publicly available sequences. Clinical and epidemiological data were obtained from DATASUS, e-SUS, and SIVEP GRIPE (data recording systems of the Brazilian Ministry of Health)
Results Of these, 143 were classified as XBB and 586 were other Omicron lineages. The BQ.1.1 lineage was most frequent. In March 2023 (EW 10), XBB became dominant, accounting for 83·3% of cases. 97·7% of XBB-infected patients successfully recovered from the infection, with a low mortality rate. Even receiving three vaccine doses and previously infected, 59·5% of the patients experienced reinfection with XBB. However, the interval between XBB infection and the last vaccine dose exceeded a year, potentially causing antibody decline. In addition, we identified 90 mutations in RS circulating XBB, spread throughout the genome, notably in the Spike protein region associated with immune resistance.
Conclusion This study provides insights into the dynamics and impact of a recombinant variant becoming predominant for the first time in the state. Continued surveillance of SARS-CoV-2 genomic evolution is crucial for effective public health management.
Introducing monitoring technologies in Chinese cities: Pollution reduction effects, enforcement strategies, and welfare consequences
Authors: TANG YIQI , Zhao Jing , Zhu Xufeng , Zhu Junming
Published: March 2024

Monitoring technologies are widely used to enhance compliance for better environmental quality. While these technologies often bring pollution reduction, much is unknown about the enforcement strategy of local authorities and its welfare implications, given technologies’ spatially limited accessibility. Here we show the impact of nation-wide establishment of 1,436 air-quality monitoring stations in Chinese cities on pollution reduction, local enforcement strategy, as well as social welfare consequences. Leveraging high-resolution datasets and a quasi-experimental design, we find that newly introduced monitoring stations led to an 8.03% (9.6972 µg/m3) reduction in PM2.5 concentrations in urban areas. Within those areas, the stations resulted in 0.57% (0.3046 µg/m3) more reduction in PM2.5 concentrations in areas accessible by the stations compared to non-accessible areas. The air-pollution reduction was associated with decline in industrial activities and change in land use, and led to higher housing price in technically accessible areas within cities. The back-of-the-envelope calculation shows substantial urban spatial inequalities in welfare consequences, driven by health benefits, for urban residents close to monitoring stations. Our findings suggest that the application of monitoring technologies should take environmental justice into consideration for a more comprehensive idea of sustainable development.
Synthesis and characterization of conjugated PVA/PANi blend doped with functionalized Graphene for Thermoelectric Applications
Authors: Morad M. A. , Ghazala M. S. Abo , El-Shaarawy M. G. , Gouda M. E. , Elrasasi T. Y.
Published: March 2024

Flexible nanocomposite thick films consisting of PVA0.7PANi0.3 polymer blend doped with different concentrations of functionalized Graphene (FGNPx) (where x = 0, 5, 10, 15, 20, and 25 wt.%) were synthesized using the solution cast technique. Scanning Electron Microscopy (SEM), X-ray diffractometer (XRD), Energy Dispersive Spectroscopy Analysis (EDX), and Fourier- Transform Infrared Spectra (FT-IR) were used to study the structure of the samples. The results showed that the ordered structure, its orientation, the PANIs' well dispersion, the 𝜋 − 𝜋 stacking, and the electrostatic forces play a significant role in enhancing the interfaces between the polymer blend and the FGNP. Thermogravimetric Analyses (TGA) and Thermoelectrical analyses (TE) showed that the PVA-PANI conducts a promised conjugated blend for thermoelectric applications. The introduction of the FGNP contents into the blend increased the TE measurements as the DC electrical conductivity ≈ 0.0114 (S.cm−1), power factor ≈ 3.93x10− 3 (W.m−1 .K−2 ), and Z.T. ≈ 8.4x10− 7, for the 25 wt. % FGNP nanocomposite film. The effect of the polymers’ phonon contribution in the thermal conductivity controlling and enhancing the thermal stability of the prepared nanocomposite films.
Computational fatigue analysis of the Almen strip treated with double-sided shot peening and its experimental verification
Authors: Wang Chengan , Kim Taehyung
Published: March 2024

The purpose is to research the effect of different shot peening parameters on the fatigue life of double-sided shot peening of SAE1070 steel. The method that in this paper, establishes a DE-FE (Discrete element-finite element) random multi-shot analysis mode is firstly used to simulate the processing of double-sided shot peening on SAE1070 steel using different shot peening parameters respectively, and then the shot peened parts are imported into fe-safe software for fatigue simulation test, and the same conditions are used to conduct double-sided shot peening test on SAE1070 specimen, and then the shot peened parts are subjected to fatigue life test. Finally, the simulation results are compared with the test results. Thus, the results of the simulation and experimental analyses are relatively consistent. In conclusion, shot peening treatment can effectively enhance the overall mechanical properties of SAE1070 alloy steel and increase its fatigue life. Significant differences in the shot peening effects at various intensities were observed, and optimal shot peening parameters can lead to the best shot peening results, resulting in relatively accurate predictions of fatigue outcomes.
Automatic Early Detection of Tomato Leaf Disease using IoT and Deep Learning
Authors: Arafat I. Sheik , Aswath S. , Nishath S. M Haji
Published: March 2024

Tomato plants are defenseless to different illnesses, including bacterial, contagious, and viral contaminations, which can fundamentally lessen crop yield and quality on the off chance that not identified and treated early. Farmers may experience increased crop damage and financial losses as a result of this detection delay. The goal is to foster a robotized framework utilizing IoT (Internet of Things) gadgets, for example, cameras conveyed in the field, joined with profound learning strategies, to precisely and quickly distinguish illnesses in tomato plants. This framework intends to give ranchers an early admonition framework that can recognize and order infections quickly, empowering convenient intercession and designated treatment, accordingly further developing harvest wellbeing and yield. Profound learning has essentially expanded the precision of picture classification and article identification frameworks' acknowledgment as of late. The exploration zeroed in on computerizing the early location of tomato leaf sicknesses utilizing IoT innovation and a changed ResNet50 profound learning model. At first, IoT gadgets, including sensors and cameras, were conveyed in tomato fields to gather plant-related information and pictures. We focused on calibrating the hyper boundaries of pre-prepared models, including GoogLeNet, SquezeNet and ResNet-50. The notable Tomato leaf disease detection dataset, which incorporates 3,890 picture tests of different sickness and healthy leaves, was utilized for the tests. Using comparable cutting-edge research, a comparative analysis was also conducted. The tests showed that ResNet-50 outflanked cutting edge models with a 99.87% more prominent characterization exactness. The framework demonstrated commendable capability in identifying whether tomato plant leaves were affected by disease in their early stages. This capability enabled farmers to receive timely alerts through mobile application, allowing for more effective management of the issue.
The metabolic role of lactate dehydrogenase in the growth of diffuse large B cell lymphoma
Authors: Zhang Jialin , Lu Qifeng , Liu Wei , Zou Jianwen , Zhou Na
Published: March 2024

LDHA activation induces tumor by activating tumor proliferation, growth, invasion, and metastasis. Whether LDHA mediated tumor metabolism that upon DLBCL occur remains unknown. Here, we investigated how LDHA adopt tumor metabolism after activation to regulate DLBCL-inducible. Here, we investigated LDHA is highly expressed in peripheral blood mononuclear cell (PBMC) of DLBCL patients. Knockdown of LDHA results in an increase in the apoptosis of cells, suppression of cell growth and migration in LY1 cells. We show that LDHA gains a canonical enzyme activity to produce lactate and triggers NAD + in DLBCL cells. Furthermore, p-STAT5 was identified as a downstream target of LDHA, and p-STAT5 protein level was significantly reduced related to decreased LDHA protein expression. Collectively, our findings identify the oncogenic role of LDHA in DLBCL and suggest that LDHA can be considered as a pivotal prognostic biomarker and a potential therapeutic target.
The isolation and identification of Bacillus velezensis ZN-S10 from vanilla (V. planifolia), and the microbial distribution after the curing process
Authors: Manyatsi Thabani Sydney , Lin Yu-Hsin , Jou Ying-Tzy
Published: March 2024

The market value of vanilla beans (Vanilla planifolia) is constantly increasing due to their natural aroma and flavor properties that improve after a curing process, where bacteria colonization plays a critical role. However, a few publications suggest that bacteria play a role in the curing process. Hence, this study aimed to isolate Bacillus sp. that could be used for fermenting V. planifolia while analyzing their role in the curing process. Bacillus velezensis ZN-S10 identified with 16S rRNA sequencing was isolated from conventionally cured V. planifolia beans. The isolate (1 mL− 1 of 10− 7 CFU mL− 1) fermented and colonized non-cured vanilla pods. PCA results revealed distinguished bacterial communities of fermented vanilla and the control group, suggesting colonization of vanilla. Phylogenetic analysis showed that ZN-S10 was the dominant Bacillus genus member and narrowly correlated to B. velezensis EM-1 and B. velezensis PMC206-1, with 78 and 73% similarity, respectively. The bacterial taxonomic profiling of cured V. planifolia had a significant relative abundance of Firmicutes, Proteobacteria, Cyanobacteria, Planctomycetes, and Bacteroidetes phyla according to the predominance. Firmicutes accounted for 55% of the total bacterial sequences, suggesting their colonization and effective fermentation roles in curing vanilla.
Assessment of phenolics in pigmented maize of Bangladesh
Authors: Preety Israt Jahan , Islam Mohammed Ariful , Rahman Jamilur , Ahmed Kamal Uddin , Hossain Ashrafi
Published: March 2024

In this investigation, we determined the compositions of phenolics, flavonoids and anthocyanins in a purple maize (SAU Bhutta 3) variety and compared its phytonutrients with those of other maize varieties cultivated in Bangladesh. The SAU purple maize contained 106.0 ± 8.3 and 165.1 ± 8.0 mg /100 g of methanol soluble and acidic methanol soluble polyphenols, respectively. The SAU Bhutta 3 had the greatest amount of flavonoids (77.0 ± 10.0 mg /100 g) and anthocyanins (69.0 ± 5.0 C3G equv./100 g) compared with the other colored maize varieties used in the investigation. The phenolic content of a hilly indigenous deep red maize cultivar was similar to that of SAU purple maize, but the former contained less flavonoids and anthocyanins than did the later. Nevertheless, the SAU white maize variety had 31.0 ± 2.0, 47.0 ± 4.4 mg FAE/100 g and 9.0 ± 2.0 mg CE/100 g of free and bound phenolics and total flavonoids, respectively, which were lower than those of the SAU Bhutta 3. Again, the SAU red maize contained the lowest level of total anthocyanin (4.11 ± 1.2 mg C3G/100 g). The SAU Bhutta 3 exhibited higher proportions of insoluble phenolics compared to total phenolics and flavonoids compared to insoluble phenolics. Overall, the SAU Bhutta 3 contained relatively high amounts of phenolics, flavonoids and anthocyanins; thus, this particular maize variety shows significant potential for future utilization as both human food and in industrial applications.
Construction and validation of an immune gene pair signature to predict biochemical recurrence of prostate cancer
Authors: Qi Siyong , Tian Kai , Liu Qizhong , Zhang Yuexi , Wang Yilin
Published: March 2024

Objective: Immunotherapy has become an important part of tumor therapy, and the important role of immune-related genes has also been paid more attention. This study aims to use immune-related genes to construct a model for predicting biochemical recurrence of prostate cancer.
Method: The prostate cancer gene expression data downloaded from the GEO database. Then we calculated the matrix of immune gene pairs and screened out immune gene pairs related to biochemistry recurrence (BCR) by univariant COX regression. The prediction model was build by lasso regression model. The dataset of GSE54460 is used as the training set, GSE2100 as validation. The ROC curve was used to evaluate the model's predictive effectiveness.
Results: In the training set, 106 BCR-related immune gene pairs were determined by univariant COX scores (p <0.001). An immune gene pair model consisting of 20 genes was constructed by lasso regression model. The optimal cutoff value was determined by the ROC curve. All the patients were divided into high-risk and low-risk groups.The survival time of the two groups without biochemical recurrence was significantly different. To further explore the role of this model, we performed enrichment analysis on genes in immune gene pairs to determine their potential signaling pathways.
Conclusion: Two independent data sets was employed to construct and verify that the prediction value of immune gene model of the biochemical recurrence of prostate cancer, and the AUC reached 0.95, which has strong potential application value in clinical practice.
Intelligent System of the Grinding Robot for Spiral Welded Pipe
Authors: Ayalew Getachew Demeissie , Yang Yang Yang , Yongtao Sun
Published: March 2024

The spiral welded pipe manufacturing industry requires strict production standards for automated grinders for welding seams. However, traditional grinding machines in this sector are insufficient due to a lack of quality control protocols and inconsistent performance. This research aims to improve the quality of spiral welded pipes by developing intelligent automated abrasive belt grinding equipment. The system has equipped with six degrees of freedom (6 DOF) KUKA KR360 industrial robots, enabling concurrent grinding operations on both internal and external welds. The grinding robot control system is designed with a PLC, and a human-machine interface (HMI) system is employed for operations. The system includes an electric speed controller, data connection card, DC driver, analog amplifier, and HMI for input data. This control system enables the grinding of spiral welded pipe. It ensures consistent production quality and cost-effectiveness by reducing the product life cycle and minimizing risks in the working environment.
Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling
Authors: Vallentgoed Wies , Hoogstrate Youri , Garderen Karin van , Hijfte Levi van , Dijk Erik van , Kouwenhoven Mathilde , Niers Johanna , Draaisma Kaspar , Martin Ivonne , de Leng Wendy , Tesileanu C. Mircea S. , de Heer Iris , Diepeveen Maud , Lavrova Anna , Eijk Paul van , Bühler Marcel , Wick Wolfgang , Clement Paul , Sanson Marc , Franceschi Enrico , Gorlia Thierry , Golfinopoulos Vassilis , Weller Michael , Weiss Tobias , Robe Pierre , Kros Johan , Smits Marion , de Wiel Mark van , Ylstra Bauke , Verhaak Roel , Bent Martin van den , Westerman Bart , Wesseling Pieter , French Pim
Published: March 2024

To study the evolutionary processes that drive malignant progression of IDH-mutant astrocytomas, we performed multi-omics on a large cohort of matched initial and recurrent tumor samples. The overlay of genetic, epigenetic, transcriptomic and proteomic data, combined with single-cell analysis, have identified overlapping features associated with malignant progression. These features are derived from three molecular mechanisms and provide a rationale of the underlying biology of tumor malignancy: cell-cycling, tumor cell (de-)differentiation and remodeling of the extracellular matrix. Specifically, DNA-methylation levels decreased over time, predominantly in tumors with malignant transformation and co-occurred with poor prognostic genetic events. DNA-methylation was lifted from specific loci associated with DNA replication and was associated with an increased RNA and protein expression of cell cycling associated genes. All results were validated on samples of newly diagnosed IDH-mutant astrocytoma patients included the CATNON randomized phase 3 clinical trial. Importantly, malignant progression was hardly affected by radio- or chemotherapy, indicating that treatment does not affect the course of disease. Our results culminate in a DNA-methylation based signature for objective tumor grading.
The Time Lag in Local Field Potential Signals for the Development of its Bayesian Belief Network
Authors: Tsukahara Victor H. B. , Junior Jordão N. O. , Ruggiero Rafael N. , Prizon Tamiris , Maciel Carlos D.
Published: March 2024

Purpose: : The objective is to suggest time as an important variable to consider in the network model, specifically when discussing causality.
Methods: : There is a consideration of the context of functional connectivity because of the time importance of observing the feature inside the neuroscience context. Using a set comprised of three rats Local Field Potentials, a network model was constructed from data using the Bayesian Network method, considering and not taking into account the time delay of communication among brain areas recorded in this study. To this end, there was the appliance of the Delayed Mutual Information method to identify the lag between Local Field Potentials and K2 Score to compare the models.
Results: : Bayesian Network depicted the probabilistic relationship among rat´s brain areas. Delayed Mutual Information captured the lag among brain areas, and after its appliance on the Bayesian Network model, posed better results.
Conclusion: : The main contribution of this study is to incorporate the minor delays inside the Bayesian Network method, achieved by applying the Delayed Mutual Information method before its application. That supports the neurophysiology dynamics considering an essential feature in the suggested methodology to support the functional connectivity analysis among brain areas.
Conductive Network Enhanced Carbon Black/Epoxy Composite Coating with Imide Curing for Antistatic and Heat-Resistance Improvement
Authors: Yang Renyu , Gan Lin , Huang Jin
Published: March 2024

Epoxy resins are essential in aircraft coatings due to their strong mechanical properties and corrosion resistance. However, their limited high-temperature resistance restricts their use in high-speed aircraft, particularly for anti-static and electromagnetic-shielding coatings, which incorporate conductive networks. The dispersion of conductive fillers is hindered by the crosslink network of epoxy resins. Here, we developed a mixture curing system combining diethylenetriamine and dicarboxylic phthalimide. This system allows imide to copolymerize with the epoxy resin, enhancing temperature resistance and optimizing the dispersion of fillers by adjusting the densities of chemical and physical crosslinks. Our results indicate that the decomposition temperature of the epoxy composite increases to 383.8 °C, suitable for aircraft exceeding Mach 3 speeds. Additionally, the percolation threshold for carbon black fillers in this system is 8.1 vol%, significantly lower than the ca. 70% in volume-exclusion systems. This reduction is primarily due to the liberation of epoxy resin segments from the chemical crosslink network. The electrical performance is also notable, with volume resistivity dropping to 0.2 Ω·m near the percolation threshold, meeting anti-static product requirements. This advanced epoxy resin system shows promise for use in electromagnetic coatings on aircraft, given its enhanced temperature resistance, anti-static properties, and mechanical strength.