bluuebunny/crossref_metadata_2025 huggingface dataset:
Психологічні детермінанти агресії як професійно обумовленої деформації особистості педагога
Authors: Шахов Володимир , Шахов Владислав
Published: September 2022

In pedagogical practice, there are enough situations in which a teacher has to make a difficult moral choice, in which he must be guided by both personal cultural and ethical attitudes and professional and ethical norms of activity. In education, this problem, first of all, affects the quality of training of young teachers, the process of entry into professional activity, adaptation to pedagogical work, ability to take responsibility for choosing a decision in conflictual, emotionally complex situations. Academic teaching, despite its priority, most often instills the future specialist with an ideal image of a teacher. The lack of information about the negative aspects of professional activity deprives a young teacher of the opportunity to assume and take into account the negative consequences of work, to respond adequately to crisis situations, to find out and eliminate the first signs of maladaptation and deformation. Therefore, issues of ethics and moral aspects of a teacher's work should become one of the areas of professional education of future teachers.
The article found out that aggression as a professionally determined deformation of the teacher's personality is a destructive behavior that is expressed in the violation of professional and moral norms of interaction between the teacher and students in the formal presence of professionally justified actions.
It has been proven that three groups of factors act as determinants of aggression as a professionally determined deformation of the teacher's personality:
1) subjective factors determined by the individual and psychological characteristics of the teacher's personality;
2) objective factors related to the features of the social and professional environment;
3) objective-subjective factors initiated by the imbalance of personal and professional development.
Aggression can be active and passive in nature, closely related to the teacher's emotional response to professional situations, and manifested in the following types: impulsive actions, hostile statements, confrontation, dominance, stereotypic differentiation and intolerance.
ПЕДАГОГІЧНА ЕТИКА Й КУЛЬТУРА ВЧИТЕЛЯ КІНЦЯ ХІХ –ПОЧАТКУ ХХ СТОЛІТТЯ
Authors: МАРЧУК ОКСАНА , ШКАБАРІНА МАРГАРИТА , МЕЛЬНИЧУК ЛІЛІЯ , ДЕМ’ЯНЧУК АНАТОЛІЙ
Published: September 2022

The problem of the teacher’s professiogramis relevant in any historical era, since it is the teacher who plays the leading role in the educational process. The effectiveness of the educational process depends on its moral qualities to a greater extent, determines the relevance of the raised problem. The study of the features of pedagogical ethics and the pedagogical culture of teachers who worked in educational institutions of Ukraine in the late XIX –early XX centuries is the goal of our research. The following research methods were used to achieve the goal of the study: historical and retrospective analysis; historical and comparative analysis; chronologically-generalizing, problem-searching, historical-analytical methods; methods of generalization and systematization.The article analyzes the definitions of “pedagogical ethics” and “pedagogical culture”. The authors presented their own definition of these concepts. According to the teaching ethics, the authors understand the system of moral values of teachers based on the principles of humanism,democracy, child centrism, respect and exactingness towards themselves and others with the aim of educating value orientations and intellectual development of the younger generation. To analyze the pedagogical ethics and culture of teachers of the late XIX –early XX centuries, the authors determined their criteria (value-oriented, scientific and professional, activity criterion) and indicators. The following documents were analyzed in detail to study the norms of pedagogical ethics and culture: “Instructions for teachers of one-class and two-class national schools” (1871), “Instruction on the educational activities of teachers of the Volyn TheologicalSeminary” (1881), "Statutes of Orthodox Theological Seminary" (1867) and other educational documents. The analysis of normative acts, reports, pedagogical diaries, archival materials on the work of educational institutions, publications of periodicals showed a high level of pedagogical culture and ethics of teachers, who carried out their activities in the Volyn province schools by certain criteria (value-oriented, scientific and professional, activity criterion). It is determined that the modern teacher, in addition to proper mastering of the latest information technologies of teaching, must have “eternal” pedagogical values, which were relevant in the analyzed time period.
Influence of Hypoxic Training on the State of Pulmonary Hemodynamics in Elderly Patients with Chronic Obstructive Pulmonary Disease
Authors: Asanov E. O. , Dyba I. A. , Holubova Yu. I. , Asanova S. O.
Published: September 2022

Abstract. The aim of the study: to find out the effect of hypoxic training on the state of pulmonary hemodynamics in elderly patients with chronic obstructive pulmonary disease (COPD). Materials and research methods. We examined 42 elderly patients with COPD, stage I-II, without exacerbation, groups A and B, that were divided into a group (21 people) wich received interval normobaric hypoxic training and a group (21 people) wich received simulated training. Pulmonary hemodynamics was studied using rheopulmonography and oxygen saturation by pulse oximetry. To assess the body’s resistance to hypoxia, a hypoxic test was performed with inhalation of a hypoxic gas mixture (12 % oxygen and 88 % nitrogen) for 20 min. The course of interval normobaric hypoxic or simulated training consisted of 10 daily sessions. All studies were conducted before training, immediately after the training course, in a month and three months after the training course. Conclusions. In elderly patients with COPD, blood circulation in the lungs is associated with the body’s resistance to hypoxia. The course of hypoxic training improves blood circulation in the lungs in elderly patients with COPD. At the same time, the beneficial effect of hypoxic training preserves for a month. In elderly patients with COPD, the effectiveness of hypoxic training’s influence on blood circulation in the lungs is associated with resistance to hypoxia. At the same time, the greater effectiveness of hypoxic training is observed in patients with lower resistance to hypoxia. Keywords: COPD, old age, pulmonary hemodynamics, hypoxic training.
Influence of C79G (Rs1072714) and A46g (Rs1042713) Polymorphism of ADRB2 Gene on Clinical Course of Chronic Obstructive Pulmonary Disease
Authors: Dmytriev K. D. , Mostovoy Yu. M. , Slepchenko N. S.
Published: September 2022

Аbstract. Chronic obstructive pulmonary disease (COPD) is a prevalent disease, that can be prevented and treated. Genetic factors play an important role in the COPD development. The aim of our study was to found ADRB2 gene polymorphism prevalence among patients with COPD, and assessment of its relation with the COPD development and clinical course. Materials and methods. 100 patients with COPD were included into the study. Source documentation, clinical and historical data were collected during study visits. Blood samples for ADRB2 gene testing were taken in all patients. All patients were treated according to GOLD guidelines, which included a combination of long-acting beta-2 agonists and long-acting anticholinergic drugs. According to the genetic analysis all patients were divided into 3 groups C79C/G46G (Haplotype 1) — 23 patients (23 %), C79G/A46G (Haplotype 2) — 26 patients (26 %), G79G/A46A (Haplotype 3) — 26 patients (26 %). Results. In correlation analysis there was a weak negative correlation between Haplotype 1 and total amount of exacerbations (r = -0.245, p = 0.032) and hospitalizations (r = -0.248, p = 0.032), and haplotype 3 had weak positive correlation with the amount of out-patient exacerbations (r = 0.263, p = 0.023). An average amount of antibiotic courses in group 1 was (1.09 ± 0.2), in group 2 — (1.69 ± 0.18), in group 3 — (2.00 ± 0.22), this difference was statistically significant (р = 0.005). There also was a significant difference in the duration of antibiotic treatment, which was (8.61 ± 1.55) in group 1, (12.88 ± 1.62) days in group 2 and (14.42 ± 1.68) days in group 3 (р = 0.036). Conclusions. ADRB2 gene polymorphism affects clinical course of COPD, which manifest in the different need in the administration of antibiotics in study groups, and also in the tendency towards different amount of exacerbations and rate of glucocorticoid use. Key words: COPD, gene ADRB2, exacerbations, antibiotics.
Observation of a Patient with Allergic Rhinitis in Ukraine: International Recommendations and own experience
Authors: Klymenko V. A. , Karpushenko Yu. V. , Kulik T. V. , Ashcheulov O. M.
Published: September 2022

Absract. The article provides an overview of the current International Recommendations on Allergic Rhinitis (AR) — ARIA (Allergic Rhinitis and Its Impact on Asthma) and EPOS (European Position Paper on Rhinosinusitis and Nasal Polyps). The issues of terminology, classification, etiology, pathogenesis, and treatment are considered. Emphasis is placed on new points: the phenotype of local AR (entopy), central compartment atopic disease, diagnosis of AR in patients with normal level of IgE and negative prick tests with inhaled allergens, determining the severity of rhinitis by visual 10-point analog scale. The differential diagnosis of AR and COVID-19 is presented (F. Ferreli, 2020; G. Malipiero, 2020). Considering the implementation of international recommendations in practice and own experience, the question of the place of allergenspecific immunotherapy (ASIT) in the algorithms for the treatment of AR is discussed. ARIA recommends ASIT for the fifth stage of treatment, after the ineffectiveness of oral steroids and biological therapy. Own observations of patients with AR prove the safety and efficacy of ASIT in the early stages of sensitization, as the first stage of therapy, which is consistent with the recommendations of other international consensuses. The need for elimination therapy has been proven on the example of the respiratory cytoprotector ectoin. Its mechanisms of action, efficacy and safety are described, according to the literature data, including a systematic review and meta-analysis of studies by Bilstein A. (2021). The own study of patients with AR indicated the prevalence of AR in the Kharkiv region — 12.2 % and 11.3 % in children aged 6-7 years and 13-14 years, respectively. The spectrum in sensitization (pollen — 64.1 %, household — 42.2 % of patients) is given. The problem of comorbidity of pathology is highlighted. The characteristic of the gastrointestinal tract in patients with allergies is given. A conclusion is made about the need to implement the international recommendations, considering the individualization of the approach. Key words: allergic rhinitis, terminology, etiology, pathogenesis, diagnosis, treatment.
Comorbidity in patients with Bronchial Asthma and Risks of Severe covid-19
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Feshchenko Yu. I. , Iashyna L. O. , Polianska M. O. , Gumeniuk G. L. , Ignatieva V. I. , Opimakh S. G. , Moskalenko S. M. , Zvol I. V.
Published: September 2022

Absract. Coronavirus disease (COVID-19) affects people of all ages and ethnic groups, men and women, and can lead to serious conditions such as pneumonia, acute respiratory distress syndrome, multiple organ failure, and even death. Patients with bronchial asthma (BA) do not have an increased risk of infection, severe COVID-19, and no increased risk of COVID-19 –related death in patients with well-controlled mild to moderate asthma. In the general population, in patients with comorbidities (diabetes mellitus, cardiovascular disease, chronic obstructive pulmonary disease (COPD), kidney disease, malignancy, obesity), COVID-19 has a more rapid progression and severe course. The aim of this study was to study the characteristics of concomitant diseases in patients with ВА as risk factors for COVID-19 according to literature sources. Patients with asthma have a higher incidence of comorbidities than the general population. In patients with asthma, the risk of detecting type I diabetes mellitus increases by 41 % compared with people without asthma, and type II diabetes, according to various estimates, from 21 to 37 %. The presence of asthma increases the risk of cardiovascular disease by 1.33 times, the presence of asthma also increases the risk of developing hypertension by 66 %, and the combination of asthma and hypertension can reach 75 % in patients with severe asthma. Up to 26 % of asthma patients have co-existing COPD. Adults with asthma have a 75 % higher risk of developing cancer compared to those without asthma. Patients with asthma may have an increased risk of developing chronic kidney disease — 6.26 % compared with 3.91 % in healthy individuals. The prevalence of obesity in patients with asthma ranges from 21.3 to 32.8 %, and in patients with severe asthma — 60 %. In general, the frequency of comorbid diseases in asthma can be 89 %, so the diagnosis of ВА does not exclude a high risk of severe COVID-19 in asthma patients with comorbidities. Appropriate intake of prescribed basic therapy, especially inhaled corticosteroids, along with treatment of comorbid conditions, is recommended for all asthma patients during the COVID-19 pandemic. Key words: bronchial asthma, comorbidity, COVID-19.
Features of the Coronavirus Disease (COVID-19) in Patients with Asthma
Authors: Sanina N. A. , Yekhanin M. S.
Published: September 2022

Abstract. The article provides an overview of modern literary data on features and characteristics of the coronavirus disease (COVID-19) in patients with asthma. Epidemiological data on the prevalence of asthma patients among the general population of patients with COVID-19 in different regions of the world (China, South Korea, the United States of America, European countries, South American countries) are presented. Differences in asthma patients infected with the SARS-CoV-2 virus depending on gender and ethnic factors were analyzed. The pathogenetic immune and non-immune risk factors of SARS-CoV-2 virus infection in patients with asthma were analyzed. It has been shown that the presence of asthma is not a separate risk factor for increased infection or a more severe course of the COVID-19. At the same time, it has been proven that there are certain features of the course and development of severe long-term consequences of the COVID-19 depending on the asthma phenotype (Th2-low and Th2-high). Thus, more severe consequences of COVID-19 are usually observed in patients with non-allergic asthma, which may be caused by the features of the pathogenesis of the disease, as well as the age characteristics of this phenotype and comorbidity with other diseases. The issue of the impact of basic and biological asthma therapy on the risk of infection, the severity of the course and mortality from the COVID-19 is considered separately. It has been shown that inhaled corticosteroids not only have an anti-inflammatory effect but can also have a direct antiviral effect on the SARS-CoV-2 virus. Therefore, therapy with inhaled corticosteroids and biologics is reasonably safe and effective and should not be discontinued during treatment for the COVID-19. Key words: asthma, coronavirus disease COVID-19, risk factors
Consequences of Acute Respiratory Infection COVID-19 and their Impact on the Course of Chronic Bronchopulmonary Diseases in Children
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Stryzh V. O.
Published: September 2022

Abstract. The article is devoted to the current problem — the impact of the new COVID-19 pandemic on the state of chronic nonspecific bronchopulmonary diseases in children. Unlike other respiratory viral infections, a significant number of patients have symptoms after an acute episode of COVID-19, associated with post-infection COVID-19 syndrome for several weeks or months. The post-acute effects of COVID-19 are called differently in different parts of the world now and are recognized as post-infectious COVID-19 syndrome or long-COVID syndrome, or the post-acute effects of SARS-CoV-2 as a well-documented multisystem disease in adults. Much less is known about the long-term effects of COVID-19 in children, and its genuine prevalence, pathogenesis, and long-term effects have been little studied. The article presents modern scientific ideas about the reasons for the development of a long post-COVID period, which include chronic systemic inflammation, endothelial dysfunction, coagulation disorders, autoimmune reactions and some other immunological changes. There are also studies on the features of postCOVID syndrome in children with bronchial asthma, recurrent pneumonia, cystic fibrosis, bronchopulmonary dysplasia. Isolated works showing how the post-infectious COVID-19 syndrome affects the course of chronic non-specific diseases of the bronchopulmonary system in children have been found. The literature review shows the high relevance of developing new technologies for accompanying children in the post-COVID period and defining strategies to prevent the adverse effects of coronavirus disease, especially among a cohort of patients with recurrent and chronic bronchopulmonary diseases. This new condition, pediatric post-infection COVID-19 syndrome, requires a multidisciplinary approach with international awareness and consensus to facilitate the early detection and effective treatment of children. Key words: pandemic, post-COVID-19 syndrome, children, chronic bronchopulmonary diseases.
Acute Urticaria as a Current Multidisciplinary Problem
Authors: Zaikov S. V. , Bogomolov A. Ye. , Kуrуlenko T. V. , Grуshуlo A. P.
Published: September 2022

Abstract. The article is devoted to an actual multidisciplinary problem — etiology, pathogenesis, diagnosis and treatment of acute urticaria (AU). It belongs to the 20 most common skin diseases, and it is faced not only by allergists and dermatologists, but also by therapists, pediatricians and other doctors. In therapeutic and especially pediatric practice, AU is of particular interest, which is associated with significant diagnostic and therapeutic difficulties. The prevalence of AU ranges from 1 to 5% in the population, and among the child population, the incidence of AU reaches 6.7 %. The most common triggers for AU are drugs (38.1 %), infectious agents (35.2 %), stress (24.7 %), and food (17.8 %). AU pathogenesis is based on degranulation and release of mediators from mast cells. Their activation during AU can be caused by both immunological factors mediated by specific receptors on cell membranes and non-immunological factors. The diagnostic process begins with the collection of complaints, anamnesis data and physical examination. The volume of laboratory and instrumental examination of patients with AU is determined by the intensity of clinical manifestations, duration of the disease, response to therapy, as well as external symptoms. There are no routine indications for laboratory testing in AU. If an allergic genesis of AU is suspected, specific allergy diagnostics are indicated. Antihistamines of the second generation remain the basis of treatment for patients with urticaria, and in case of their insufficient effectiveness, omalizumab and cyclosporine are added to the treatment regimen. Short courses of systemic corticosteroids may be prescribed in rare cases of severe disease. Key words: acute urticaria, etiology, pathogenesis, diagnosis, treatment.
An Analysis of the Judicial Enforcement of Social and Economic Rights
Authors: Farid Naghma , Khan Muhammad Siraj , Saleem Kashif
Published: September 2022

The modern concept of human rights can be traced back to the European Renaissance. However, it was only after the foundation of the United Nations Organization that practical steps toward global recognition and enforcement could become possible. The Universal Declaration of Human Rights(UDHR) is a unique document in the sense that never before in the history of mankind, nations did agree on universal human rights standards. As it was a declaration and non-binding in nature, it was succeeded by two conventions namely, the International Convention on Civil and Political Rights (ICCPR) and the International Convention on Social Economic and Cultural Rights(ICSER), each comprising of a separate set of human rights. On the other hand, their champion sargue that civil and political rights are a wasteful luxury for an empty belly.
The Impact of Judicial activism on The Economic Matters of Pakistan
Authors: Gul Noman , Farid Naghma , Khan Muhammad Siraj
Published: September 2022

A well-established judiciary ensures a conducive environment for economic growth; relations between legal fraternity and investment have been interlinked, if there is no stable judiciary political miser ability, loopholes in securitymatters, law and order scenario, and energy situation shall be in a worse position. On the contrary, an efficient judiciary shall safeguard and protect the confidentiality of the business class in the country. For the smooth functioning of the economic sector property rights,contracts, and non-discriminatory behaviour on the part of the government ensures economic growth, investors always fear fake accountability and threatening situation in the country.
Caught in Transition: Ama Ata Aidoo's Search for a New Ghanaian Woman
Authors: Saeed Sohail Ahmad , Naeem Ahmad , Shaheen Muhammad Mahmood Ahmad
Published: September 2022

This paper brings out the Womanist perspective in Aidoo’s No Sweetness Here and Other Stories. The term ‘Womanism' encapsulates the varied dynamics of the black woman's literary experience as it distinguishes itself from the feminism of the White Woman. The predicament of women in postcolonial Ghana is the focus of Aidoo’s attention. Aidoo’s vision is historical, also. In her short stories, she explores the challenges faced by women in post-independence Ghana. In the period of transition, the African woman's identity is brought into conflict with traditions and cultural modernization. Aidoo’s predominant concern is to reflect on women’s increasing alienation in contemporary African society with the help of tradition and modernity. In Aidoo’s vision, Africa’s progress is inseparable from the social, economic,political and psychological liberation of women. No Sweetness Here and Other Stories attempts to make African women aware of their agency, which is the first step towards their liberation.
The Exploration of Women's Suffering Under Patriarchy in the Work of Waris Dirie's Desert Dawn
Authors: Ali Haider , Saqib Muhammad , Zeb Kamran
Published: September 2022

The history of the sufferings of a woman is tricky, turbulent but therapeutic as well. Women through the ages has suffered either at the hand of religion or culture. Male dominancy has reduced woman mostly into a second-class denizens of the world. One-half of the human race is still living amidst cruel practices. Is she really so helpless or impotent? In the character of Waris Dirie, we see she is not. Yes, she does become one when she doesn't have an understanding of her strength. She is exploited in the name of patriarchy. She falls prey to certain prejudicial practices ordained by culture or tradition or providence.This research is meant to highlight the travails of Waris Dirie and dispel the impression of a woman being 'an incomplete being' as promoted in a male-identified society.It is time, in the words of Mary Wolston Craft, that a degree of reason, virtue and knowledge should replace outdated cultural practices against women. (Wollstonecraft, 1796).
Destructive Innovation to the Unsustainability of the Environment
Authors: Sadiq Nayab , Sarfraz Maliha , Javed Amara
Published: September 2022

This article explores the causes of environmental degradation and aims to explain the interconnection of state, capital, and masses as enhancing environmental degeneration. Innovation and production processes have progressed under the guise of economic gains, and entrepreneurs' efforts to produce new things, coupled with capitalistic mottos,added to the hazardous environmental pollution. My argument is backed up by the theory of tread mill production as a political-economic explanation of the causes of environmental degradation. This stance refers to the extensive capitalistic search of the state and masses as getting stuck on a "treadmill" where they have not improved economically, yet their pursuits for economic development lead them to damage the environment. Using the narrative of New York 2140, this study warns about the possible menace thwarted back by the environment. This study highlights how the innovation process under capitalistic goals leads to unnecessary over-consumption, which ultimately results in environmental unsustainability.
Judicial Activism and Constitutional Challenges in India
Authors: Gul Noman , Farid Naghma , Khan Muhammad Siraj
Published: September 2022

Courts in India intervened in policy matters; education, environment, property rights, and cleanwater are some of the areas in which precedents have been established. Supreme Court has become a final interpreter of the constitution. It even checked the amendments made by parliament. A weaker political system provided a feeding ground for the judiciary to intervene in the matters of the executive and legislatures. By noticing the checkered history, the emergency of the 1970s has weakened the judiciary which has been compensated in the last few decades. Powers belong to those who utilized them. The unconstitutional dismissals provided a vacuum for the judiciary to play its role. The judicial review,interpretation of fundamental rights, environmental issues, constitutional amendments and appointment of judges, have broadened the jurisdiction of courts in India.
Walter Benjamin vs. Carl Schmitt: Giorgio Agamben Intensifies the Debate on the State of Exception
Authors: Raza Syed Sami
Published: September 2022

In his book State of Exception, Giorgio Agamben seeks to build a public law theory of the state of exception. The concept is in its evolution for a century now. The initial philosophical debate on it, an explicit one,took between Carl Schmitt and Hans Kelsen. Apart from it, according to Agamben, an implicit debate between Walter Benjamin and Carl Schmitt. Excavating and analyzing this debate, Agamben demonstrates that Benjaminsubverts Schmitt's effort to justify and rationalize exceptions to (the rule of) law. While Agamben Agamben'sreenactment of the debate between Benjamin and Schmitt is illuminating and valuable for conceptual purposes, Iargue in this essay, by engaging a textual analysis approach, that his highlighted juxtapositions are asymmetric,the arguments are reiterative, and the dialogic ends up in ambiguity.
An Appraisal of the Transgender (Protection of Rights) Act, 2018 in the Light of Islamic Law
Authors: Khan Muhammad Siraj , Shah Raza Ullah , Farid Naghma
Published: September 2022

In Pakistan, a bill was passed in 2018 under the pretext of safeguarding the rights of transgender persons. Since its enactment, it stirred controversy and remains a subject of debate to this day in terms of its corresponding consistency with Shariah (Islamic Law). However, dueto a lack of proper understanding, the confusion is not just limited to ordinary citizens but is widespread among highly educated citizens as well. The Constitution of 1973 declares that the state religion shall be Islam and holds that no law contrary to the injunctions of the Holy Quran and Sunnah shall be made.It is in this context that this article examines the controversial law making a comparison with the corresponding rules of Islamic Law over the subject and suggests that the legislature shall, after seeking proper assistance, revisit and amend it to bring it in conformity with the Shariah Law.
Enforced Disappearance and the role of Law Enforcement Agencies and Judiciary in Pakistan
Authors: Khan Muhammad Siraj , Gul Noman , Farid Naghma
Published: September 2022

Enforced disappearance has become a global phenomenon; over one million have disappeared in the last 50 years,(Sarkin, 2012). Since the Afghan war, the incident began to start in Pakistan and the law enforcement agencies turned a blind eye to it. The International Convention for the Protection of all people from enforces Disappearance (2006) looks after the events globally and has concluded in an article that: "...the arrest, detention, abduction or any other form of deprivation of liberty by agents of the State or by persons or groups of persons acting with the authorization, support or acquiescence of the State, followed by a refusal to acknowledge the deprivation of liberty or by concealment of the fate or whereabouts of the disappeared person, which place such a person outside the protection of the law" (Convention for the Protection of all people from enforces Disappearance, 2006).
The National Accountability Bureau of Pakistan: Role for Elimination of Victimization against Opposition Leaders
Authors: Raza Ahmad , Farid Naghma , Khan Muhammad Siraj
Published: September 2022

Since the establishment of NAB (1999), it has been used for the victimization of politicians, especially by the ruling party;Number of fake cases have been registered against the opposition political parties and politicians who proved a stigma onthe transparency of the institution. There have been internal weaknesses within the NAB; politicians consider it a tool of adictator. It can arrest a person for investigation for 90 days, which is against the violation of human rights. There is a needto train the members with professionalism to counter the challenges of modern times.
Divine Illumination Vs Infinite Reality in Mian Muhammad Buksh's Saif-ul-Malook
Authors: Rasool Asma Ghulam , Pervez Nafees , Khalil Sidra
Published: September 2022

This research unfolds the spiritual essence of literature and the worth of Punjabi Sufi literature within the periodical era of world literature. It explains the pivotal points of divergence and similarity between the opposing heroic concepts of eastern philosophy.The study highlights the philosophy of eastern literature through the portrayal of heroes. The researcher also pivots differences with theological, spiritual and institutional aspects of epics in general. By this discrepancy portrayal of heroes, the research exposes their concept of being or not along with the recipient of Divine illumination. The description of the hero of the selected work i.e. the Prince Saif-ul-Malook, from Saif-ul-Malook, explains the settings and situations of a given time and place. The hero accomplishes his definitive goal toward the infinite reality.He is a man who possesses superman renderings but becomes unable to prove himself as a recipient of Divine illumination. The main and ultimate aim of this research is to prove the extent of assimilation of Divine illumination and auxiliary to meet the infinite reality.
THE SUBSTANTIATION OF THE CONCEPT OF GLIOARCHITECTONICS FOR NEUROSCIENCE AND NEUROCYTOPATOLOGY
Authors: Makarenko O.M.
Published: September 2022

The analysis of the structure and functional state of gliocytes enables to characterize the cytological parameters of various brain cell formations, normally, to objectively assess not only the impact on the formation of pathological factors (including their glial cell homeostasis), but also to assess the therapeutic effectiveness of different drugs in managing different CNS pathologies. The aim of this study is to promote the concept of glioarchitectonics for an in-depth and detailed study of the cerebral cortex (neocortex) in normal, experimental and clinical pathology of the central nervous system. This study is based on the analysis of the latest literary sources and the results of the authors' previous research. The system-cellular indicator of the evaluation of the glial formula (GF) characterizes the quantitative (percentage) content of individual cell types (astrocytes, oligodenrocytes, microgliocytes) in relation to the total number of gliocytes in a standard area of ​​a histosection. The glial quantitative index characterizes the ratio of one type of gliocytes to another. In particular, index 1 represents the ratio of the sum of astrocytes to microgliocytes, index 2 represents the sum of oligodendrogliocytes to microgliocytes, and index 3 demonstrates the sum of astrocytes to the total number of oligodendrogliocytes. The use of quantitative methods of analysis in the study of the glial system of various cellular brain structures in health, in disease and after pharmacotherapy of experimental cerebrovascular pathology showed that these methods are sensitive and suitable for solving a number of theoretical and clinical tasks. This study has demonstrated that the analysis of the results of the glial formula and glial quantitative indices contributed to objective analysis of the structure of glia of various cellular brain formations in health in order to improve the parameters of evaluating the relevant histological characteristics. The obtained results can help to carry out not only qualitative, but also quantitative assessment of the impairment of glial homeostasis in various cellular formations of the brain (cerebrocortex, various nuclei of the hypothalamus) when modelling glial indices. The results of the study of glioarchitectonics and system indicators of the evaluation of the glial formula and glial indices of the quantitative glial system contributed to in-depth and detailed understanding of various cellular formations in the brain in health, in disease and after pharmacotherapy of experimental cerebrovascular pathology.
ENHANCEMENT IN THE TREATMENT OF SEPTIC WOUNDS BY VACUUM THERAPY
Authors: Zubakha A.B. , Ligonenko O.V. , Shumeiko I.A. , Storozhenko O.V. , Skotarenko T.A.
Published: September 2022

The doctrine of the wound process is still one of the challenging issues of modern surgery; it reflects the achievements of theoretical and practical medicine and technical engineering as well. Slow-healing wounds, extensive necrosis in soft tissues, trophic ulcers of shins in patients with circulatory disorders of various aetiology, purulent bedsores, infected burn surfaces and other septic-inflammatory processes are particularly difficult to treat. The principles and methods of surgical treatment and pharmacotherapy over the phases of the wound process are aimed at reducing the infectious complications and core protocols provide standard guidance for appropriate prevention and management of infected wounds.

The use of vacuum therapy (VAC therapy) according to numerous clinical studies improves both immediate and long-term treatment outcomes, updates standard therapy regimens for septic processes in soft tissues, especially in the presence of associated microbial colonies.

The aim of the study is to evaluate the clinical efficacy of VAC therapy methods incorporated into a standard management of infected inflammatory wounds. The article presents the analysis of the case histories of 50 patients with acute septic inflammatory processes, who took the treatment course at the surgical department of Poltava Clinical Central District Hospital. The main group of 20 patients included 5 men (average age 52.2 ± 5.1 years) and 15 women (average age 51.4 ± 4.1 years). The control group involved 30 patients: 11 men (mean age 48.6 ± 3.7 years) and 19 women (mean age 54 ± 4.2 years). According to the character of surgical problem, patients were divided as follows: purulent-necrotic form of erysipelas was found in 11 patients (5 patients in the main group, 6 patients in the control), infected thermal burns were diagnosed in 11 patients (4 individuals in the main group and 7 individuals in the control), fооt phlegmon as diabetes complication was found in 13 patients (5 individuals in the main group, 8 individuals in the control), trophic ulcers of shins due to chronic venous insufficiency were detected in 15 patients (6 individuals in the main group, 9 individuals in the control). The VAC therapy methods allowed us to significantly reduce the period of wound cleansing, to accelerate the appearance of granulations, and that is the most importantly, to reduce the treatment duration in 1.5 times. The VAC-therapy for local treatment of septic-inflammatory processes is relatively inexpensive and quite effective therefore, it can be recommended for wider use in surgical practice.
IMPROVING THE EFFICIENCY OF TREATMENT OF TROPHIC ULCERS IN THE LOWER EXTREMITIES RESULTED FROM CHRONIC VENOUS INSUFFICIENCY
Authors: Abbasaliev B. B.
Published: September 2022

The prevalence of varicose veins of the lower extremities and trophic ulcers, and as a consequence, deterioration of the quality of life, high rate of disability pose this problem as one of the social and healthcare challenges. The aim of the study is to evaluate the effectiveness of the low-intensity laser radiation in the integrated treatment of trophic ulcers of the lower extremities. Clinical and histomorphological studies were performed on 75 patients, 21 men and 54 women, aged from 15 to 75 years, who took the course of treatment for small and medium stage II ulcers on the lower extremities at the Educational and Surgical Clinic of the Azerbaijan Medical University and the Central Hospital of the Gazakh district. Criteria for inclusion in the study: both sexes, the presence of ulcerative necrotic lesions of the lower extremities. Exclusion criteria: heart failure, systemic diseases, cancerous diseases, hormone therapy, pregnancy. To conduct a comparative analysis, patients were randomly divided into three groups (25 individuals in each group): the main group, the comparison group and the control group. Venocoryl ointment, low-intensity laser radiation and endovenous laser ablation were used in the treatment of trophic ulcers of the lower extremities of small and medium sizes in the main group. The control group received regional treatment including standard retro-specific methods and endovenous laser ablation. The comparison group received endovenous laser ablation and Venocoryl ointment. When using Venocoryl ointment, low-intensity laser radiation and endovenous laser ablation in the treatment of trophic ulcers with leg varicose veins, a more pronounced decrease in pain sensations, faster relief of the inflammatory process and activation of reparative processes were observed on the 7th and 14th days after the beginning of the therapy compared to the control group and the comparison group. The use of Venocoryl ointment, low-intensity laser radiation and endovenous laser ablation reduces pain in the main group after 7 and 14 days compared with the control group.
DYNAMICS OF MMP8 AND OSTEOPONTIN CONTENT IN ORAL LIQUID OF PATIENTS WITH ORAL DISEASES IN THE PRESENCE OF ONCOPATHOLOGY
Authors: Filon Andrii
Published: September 2022

According to WHO, breast cancer is one of the most common forms of cancer in women. In 2020, 2.3 million women were diagnosed with breast cancer and 685,000 deaths from the disease were reported worldwide. This research aims to study the dynamics of the concentration of MMP8, osteopontin, and Ca2+ ions, as well as the pH level in patients with breast cancer during chemotherapy and specific dental treatment. Materials and methods. The study involved 60 patients, both men and women. All respondents were divided into groups by their oncological diseases: group 1 consisted of 20 patients with stage II and III breast cancer after chemotherapy, without prior dental treatment, group 2 comprised 20 patients with breast cancer after chemotherapy, with previous dental treatment, the control group included 20 people without cancer and dental pathology. Results and discussion. Dental diseases in patients of both groups were manifested by significant changes in bone metabolism, which was accompanied with sharp rise of MMP8 concentration in oral fluid during reducing osteopontin concentration. It is worth noting that the above pathobiochemical changes occurred against the background of a fall in the Ca2+ ion content and a pH shift towards the acidic side. The increase in Ca2+ is associated with a decrease in MMP8 level and the elevation in pH and osteoponine. In turn, the pH has medium power feedback with MMP8 and a direct relationship of medium force with osteoponin. MMP8 and osteopontin are associated with strong feedback, that is, an increase in the level of one of them can be displayed about reducing osteopontin. Conclusion. This study has established a statistically significant increase in MMP 8 against the background of the reducing concentration of osteoponitis. Pathobiochemical changes in bone tissue were found against the background of significant loss of Ca2+ ions and pH. Dental treatment for this category of patients has led to the improvement in the concentration of these markers. The data obtained justifies the necessity of their use as diagnostic markers and laboratory screening of the effectiveness of dental treatment in patients of this category.
FORENSIC MEDICAL ASPECTS OF SEVERETY OF CHEST INJURIES IN SURVIVORS
Authors: Gubin M.V. , Borsch S.S. , Saenko M.S. , Churaev V.O.
Published: September 2022

Relevance: closed chest injury is one of the most common types of injuries that can cause life-threatening conditions. Victims with such injuries often require carrying out a forensic medical examination. The purpose of this study is to determine from forensic medical aspects the severity of chest injuries in patients treated in a specialized surgical hospital in order to establish additional criteria for forensic diagnosis of such injuries. Materials and methods: 66 medical histories of patients with chest injuries who were treated at the V.T. Zaitsev Kharkiv Institute of General and Emergency Surgery. Results. A forensic medical assessment of the severity of chest closed injuries of the chest based on of clinical findings was performed. Morpho-clinical approach was used to determine the severity of injuries. Severe injuries were estimates in 22.7% of cases, mainly in the case of following acute respiratory failure. Moderate injuries were estimated in 77.3% of cases, mainly in injuries with rib fractures that caused no danger to life. It has been established that in the available scientific and methodological literature there are no diagnostic morpho-clinical signs for qualitative forensic assessment and prediction of the final results of closed chest injuries; moreover, there exist different views on forensic assessment. Conclusions: this study has determined that when using the morpho-clinical approach of forensic assessment, the additional diagnostic signs of closed chest injuries should be applied when assessing the severity of injuries including dynamics and duration of recovery from posttraumatic morpho-functional changes of injured organs, loss of a part or whole respiratory organ (lungs), the emergence of life-threatening conditions. The ways of further improvement of forensic diagnosis in the assessment of such injuries by the degree of their severity have been identified.
Zdzisław Żywica, Ewangelia według Świętego Mateusza. Wstęp, przekład z oryginału, komentarz (Biblia Impulsy. Nowy Testament 1/1-2; Katowice: Księgarnia św. Jacka 2019)
Authors: Ledwoń Dawid Łukasz
Published: September 2022

Recenzja książek:
Zdzisław Żywica, Ewangelia według Świętego Mateusza .Rozdziały 1–13. Wstęp, przekład z oryginału, komentarz(Biblia Impulsy. Nowy Testament 1/1; Katowice: Księgarniaśw. Jacka 2019). Ss. 272. PLN 29,90. ISBN 978- 83-8099-074-6
Zdzisław Żywica, Ewangelia według Świętego Mateusza .Rozdziały 14–28. Wstęp, przekład z oryginału, komentarz(Biblia Impulsy. Nowy Testament 1/2; Katowice: Księgarniaśw. Jacka 2020). Ss. 288. PLN 29,90. ISBN 978-83-8099-119-4
PERANCANGAN RUMAH TINGGAL YANG MERESPON KONDISI PANDEMIK; PASSIVE DESIGN SEBAGAI UPAYA UNTUK MENYARING PATOGEN
Authors: Mubarrok Noor Zakiy , Adityo Adityo , Alfionita Clarissa , Mulyadi Event Alviando , Utaminingtyas Brigita Murti
Published: September 2022

Abstract: Adaptation to the pandemic has been going on from past eras. An increasingly modern society learns a lot from the previous case in dealing with the next pandemic. Technological advances and new discoveries in various fields make it easy for humans to deal with existing conditions, both individually and systematically. But does it ever come to our thoughts if we are in the worst condition when we cannot rely on technology anymore, when all systems are shut down, when we are in such catastrophe, is there anything we can do? This design tries to find a solution by utilizing the existing natural potential and our adaptation as a human, wisely. Cyclical Design Process used in the design process, starting with analysis; both programmatic and site analysis, synthesis which consist of conceptual, zoning and the design implementation, and evaluation using the ENVI-met software to evaluate and also to prove the design. The result is a house with multi mass, which has different orientation, connected by the courtyard to maximize the daylight and natural ventilation inside the house, and also separating the activity of the inhabitant, to minimize the spread of the virus among the inhabitants. Vegetation chosen in this design for supporting the passive design system, as a pathogen trap and ensuring food sufficiency for inhabitants.Abstrak: Adaptasi terhadap pandemik telah berlangsung selama berabad-abad. Masyarakat modern mempelajari kasus yang terjadi sebelumnya guna menghadapi kondisi pandemik berikutnya. Kemajuan teknologi dan ilmu pengetahuan memberikan kemudahan bagi masyarakat untuk menghadapi kondisi yang ada, baik secara individu maupun sistemik. Permasalahan yang diangkat adalah bagaimana jika dalam kondisi terburuk, teknologi yang membantu dan memudahkan kita beradaptasi tidak dapat digunakan. Rancangan ini mencoba untuk mencari solusi dengan memanfaatkan potensi alam yang ada serta adaptasi kita sebagai manusia dengan bijak. Metode Cyclical Design Process digunakan dalam proses perancangan, diawali dengan analisis programatik dan analisis tapak, sintesis yang meliputi konsep, zonasi dan implementasi desain serta evaluasi terhadap rancangan dengan menggunakan software ENVI-met untuk pembuktian rancangan. Hasilnya sebuah rancangan rumah tinggal multi massa dengan orientasi massa yang berbeda, dihubungkan dengan taman di tengah massa bangunan guna memaksimalkan pencahayaan dan penghawaan alami dalam ruang, sekaligus memecah aktivitas guna meminimalkan penyebaran virus diantara penghuni. Penggunaan vegetasi dalam perancangan selain untuk memaksimalkan sistem desain pasif, penyaring patogen serta memenuhi kebutuhan pangan mandiri bagi penghuni.