bluuebunny/crossref_metadata_2025 huggingface dataset:
FORMAÇÃO DA ESTRATÉGIA EM CONDIÇÕES DE ELEVADA INFLUÊNCIA GOVERNAMENTAL: UMA ANÁLISE LONGITUDINAL DA FUNDAÇÃO DE APOIO À PESQUISA CIENTÍFICA E TECNOLÓGICA DO ESTADO DE SANTA CATARINA – FAPESC
Authors: Pereira Maurício Fernandes , Oening Karla Simoni
Published: December 2015

This research analyzes the process of strategy formation in the Foundation of Support to the Scientific and Technological Research of the State of Santa Catarina - FAPESC, a body of the government’s direct administration structure in the State of Santa Catarina, with the purpose of understanding how its construction occurs: if in a deliberate way, anticipated and rational; or, as an emergency, in consequence of the interactions of the agents present in the organizations’ routine. By way of a case study of longitudinal, historical and biographical character, and based in the procedures proposed by the Direct Research (MINTZBERG, 1979; MINTZBERG; McHUGH, 1985), the history of the institution was retrieved in the period comprised between the years of 1990 and 2005. The data has disclosed that, in adapting itself strategically, beyond the predominance of a planned and sistemic strategic behavior, the institution suffered an intense influence from the governmental politics of the State and this, associated with the low power to influence the environment with high environmental determinism, reduced the importance of the management scienter in the success of the company indicating that mechanisms of environmental selection operate to the detriment of the adaptation. Key words: Strategy. Change and adaptation. Formation of the strategy.
CONTABILIDADE ESTRATÉGICA DE RECURSOS HUMANOS: NO CONTEXTO DA GESTÃO DO CONHECIMENTO
Authors: Prudêncio Tinoco João Eduardo , Sell Isair , Herbst de Lima Miriam Leopoldina , Da Silva Tarcísio Pedro
Published: December 2015

This article elaborated in the context of the Theory of Accountancy gives evidence of and makes explicit the importance of Human Resource Costing and Accounting (HRCA) for the Entities. The article deals with the recognition of people as a strategic and organizational resource, with the objective of being competitive in search of maximizing the return on investments in physical, technological and human resources. It is reported that in the current society of knowledge, the success of organizations is in recognizing, retaining and maximizing this resource, which constitutes an asset par excellence, in search of continuity in entities in time, allowing, moreover, the divulging of its perfomance to its partners. The article explains that human capital is not supplementary information but is relevant information for the stakeholders which must be divulged through published accounts, to attend the presuppositions of accountability. Key-words: Strategic accountancy. Human resources. Context of management of knowledge
O USO DE PROGRAMAS DE COMPUTADOR NA ANÁLISE QUALITATIVA: OPORTUNIDADES, VANTAGENS E DESVANTAGENS.
Authors: Moreira Daniel Augusto
Published: December 2015

Qualitative Data Analysis Software is not extensively used in Brazil; also, misconceptions about qualitative research are still common. This study presents the main functions of Qualitative Data Analysis Software or, more properly, CAQDAS - Computer Aided Qualitative Data Analysis Software, as it is well known in the academic world. The relationship of CAQDAS with grounded theory is stressed, and so is text coding, as the central operational issue in grounded theory. Vantages and advantages of using software packages are analyzed. However their huge potential for facilitating data storage, manipulation and retrieval, their use is not always necessary or even recommended. As the packages are not neutral concerning theory, the analyst has to decide if and when to use a computer program and, if the package is in order, which one to use. Key words: Data analysis. Computer software. Qualitative research.
ABORDAGEM DETERMINÍSTICA E DE SIMULAÇÃO DE RISCO COMO INSTRUMENTOS DE ANÁLISE DE VIABILIDADE FINANCEIRA EM INVESTIMENTOS IMOBILIÁRIOS
Authors: Silva Francimar Natália , Ferreira Marco Aurélio Marques , Pazzini Felipe Luis Santiago , Abrantes Luiz Antônio
Published: December 2015

Nowadays, the real state market is one of the most significant sections of the Brazilian economy being considered great employment generator and income. This facilitates to move great volumes of financial resources, due its high level of sectorial interrelation. This way, the success of the investment in real state enterprises is fundamental, because this is an key-activity for the national development. Because of that, it makes necessary a previous analysis of financial viability so that the entrepreneur has larger safety taking his decision. However, there are few works specifically linked to the real state section exist. Like this, the present study had a objective to accomplish an analysis of financial viability, complemented by simulations of risk of a project of a real state investment, which consists of the construction of three residential buildings in the municipal district of Viçosa. The financial analysis was accomplished by the methods of evaluation of real state projects and, for the risk analysis was used the technique of Monte Carlo' simulation, using the program @RISK.. The minimum rate of attractively (MRA) considered in the case studied was 1.5%. From the financial analysis, the following data were obtained: payback in the 19th month; liquid present value (LPV) of R$250,688.57; rate of internal returns (RIR) of 5.42% per month and profit index (PI) of 1.27. The result of the simulations, indicated for the exit variables, LPV, RIR and PL medium values of R$ 194.899, 30.5% a month and of 1.26, respectively. For the distributions of accumulated probabilities it can be concluded that this project of real state investment is financially viable and it has low risk. As conclusion, the process of simulation techniques in the generation of information has extreme importance for taking decisions. Key Words: Financial viability. Simulations of risk. Real state investment.
INOVAÇÃO TECNOLÓGICA E PROCESSO DE ADOÇÃO DE PRODUTOS FABRICADOS COM RESÍDUOS PLÁSTICOS PÓS-CONSUMO
Authors: Ferreira Elaine , De Souza Maria José Barbosa
Published: December 2015

The reuse of products in the recycling process results in a much cleaner production, considered innovation technology. With the aim of ascertain market viability for hoses manufactured from recycled post-consumption plastic residue, a research was carried out in 133 companies of the City of Florianopolis – State of Santa Catarina, identifying amount consumed and willingness to acquire this new product. Findings show that a substantial amount of post-consumption plastic residue, generated in the region, could be utilized for the production of hoses, and that, users of this product needed to be informed about the benefits of using a product manufactured from recycled raw material. Key words: Cleaner production.Iinnovation technology. Acceptance of new products. Post-consumption plastic residue.
ANÁLISE DAS VARIÁVEIS CULTURAIS DA GESTÃO MUNICIPAL SOB A ÓPTICA DA NOVA GESTÃO PÚBLICA
Authors: Oliveira Tatiana Souto Maior de , Rezende Denis Alcides
Published: December 2015

The new municipal management is based in the introduction of management practices from the private management in the mayor halls (Prefectures), searching for a better effectiveness in its actions. The main objective of this research is to analyze which cultural variables in the mayor halls can influence the management relates to the concepts of the new public management. Based in bibliographical research were notice cultural variables (such as: power, personalism, determinism and adaptability) from the new public management (re-structure, private practices and social participation), that direct the research protocol. Through a multi-case study, in three mayor halls of the metropolitan region of Curitiba and with the comparison of the tools of collecting data tools used (questionnaire, interviews, and systematic observation) it was possible to identify of cultural variables in the mayor halls and the deepening of the existent relationships among them. The conclusion reiterates the identification and construction of a cultural variables map could enable the municipal managers a better control and utilization in their actions. Key words: Municipal managemet. Brazilian culture. Organizational culture.
A CROSS-CONTINENTAL EXAMINATION AND COMPARISON OF DESCRIPTIVE CRITERIA IN MARKETING JOURNALS – AMJ, EJM AND JM
Authors: Svensson Göran , Wood Greg
Published: December 2015

O objetivo é melhorar a investigação transcontinental e a comparação dos critérios descritivos não tradicionais numa seleção de periódicos acadêmicos de ponta na área de marketing. A amostragem de periódicos é restrita ao exame e comparação de três destes periódicos que são: Australian Marketing Journal (AMJ), European Journal of Marketing (EJM) e the Journal of Marketing (JM), nos quais predominam estudos de caráter empírico. Além disso, mostrou-se que, nos periódicos considerados, temas gerais predominam sobre edições especiais. O exame e comparação dos critérios estão baseados numa análise de contexto de 811 artigos publicados durante o período de seis anos, entre 2000-2005. Artigos que não são classificados dentro da categoria de estudos empíricos, tais como revisão geral, revisão da literatura, papers teóricos, revisão e comentários de livros são também menos publicados. Também, mostrou-se que, nestes periódicos, foram publicadas menos edições especiais ou seções especiais. A principal contribuição deste estudo reside na investigação e comparação dos critérios descritivos em periódicos de diferentes continentes, especialmente analisando critérios que não foram explorados e relatados previamente na literatura. Palavras chave: Marketing. Periódicos. Descritivo. Critério. Investigação. Comparação. Transcontinental.
ESTRATÉGIA E JAZZ: UM NOVO PROCESSO DE FORMULAÇÃO ESTRATÉGICA
Authors: Lissoni Juliano , Costa Alexandre Marino , Moritz Gilberto De Oliveira , Pereira Maurício Fernandes
Published: December 2015

What strategy really means and how strategies are created has been an emerging topic in the field of management. This article’s main purpose is not to create a new division, but get together the theme, in order to consider strategy as a sequence of moments, that starts from strategic intent and planning, but allows the derivative behavior. The main conclusion is that the metaphoric comparison between strategy making and jazz, which some basic element of jazz performance, as experimentation and improvisation, join the collective notes, in order to bring magic moments to the audience. Improvisation and experimentation are related with jazz evolution, in which the significant and well-succeed derivative situations changed the music in a modern way, without loosing its temper. This occurs in companies as well, where tries and improvisations can bring strategic evolution. Key Words: Strategy Making. Derivative Strategies. Jazz.
A CONTROLADORIA COMO FERRAMENTA DE APOIO AS ESTRATÉGIAS COMPETITIVAS: ESTUDO DE CASO NUMA EMPRESA DE TELEFONIA MÓVEL
Authors: Dos Santos Sandra Maria , Soares Francisco De Assis , Lima Junior Carlos Alberto Correia , Tenório José Nelson Barbosa
Published: December 2015

This article aims to investigate the paper of the Managemental Accounting department of a Brazilian Mobile Phone Company in the support to the competitive strategies. This research is important because this sector is of most dymanic and import of Brazilian and worldwide, thus possessing, potential to spread new practical of management that if they show utility in the resolution of the enterprise problems. A research was carried through, involving on interviews with controllers of the Managemental Accounting sector and executives to the organization. The results had evidenced that the information of this department make possible the knowledge of the market, of form to face the competition. The agreement that the managers possess of this industry is its attractiveness. The main threat the competitiveness of the organization in the market is the degree of rivalry of the competitors. Key Words: Mobile Telephony. Managemental Accounting. Competitiveness.
PERFIL DE INVESTIDORES E FORMAÇÃO DE PORTFÓLIOS: CONTRIBUIÇÕES A PARTIR DA ANÁLISE MULTIVARIADA DE DADOS
Authors: FERREIRA Marco Aurélio Marques , Grossi Roseane , Leal Crislene , Silveira Suely De Fátima Ramos
Published: December 2015

The present work had as intention to simulate the creation of portfolios, from measurable attributes of the behavior of actions negotiated in the São Paulo Stock Exchange, taking as reference the profile of the investors and aiming at to construct to distinct sets of actions come back the different profiles of investors. The theoretical base of the article if supports on the theory of portfolio that describes the choices of financial applications capable to maximize the waited utility of an investor, from the use of performance indices. The research was constructed from secondary data by means of one ranking composed for 100 stocks negotiated in the São Paulo Stock Exchange in 2005, elaborated for five criteria. The related Ranking was developed by the Economática and was published in Você S/A (2006) with the heading “Guide of Stocks”. For the simulation of the formation of the portfolios techniques of multivariate analysis of data had been used. The results suggest it was possible the differentiation of big and small investors, from questions associates to its profile, as presented in literature of finances, and the identification of distinct criteria for the different formed clusters.
O STATUS CIENTÍFICO DA PESQUISA EM ADMINISTRAÇÃO
Authors: Walter Silvana Anita , Augusto Paulo Otávio Mussi
Published: December 2015

In this essay, it is sought to fill the theoretical gap concerning the reasons why the discipline of management finds difficulties to consolidate itself as science. Thus, two reasons are pointed out for that. The first concerns to the fact that management, as social science, does not reach any of the scientificity criteria reached by the natural sciences, which occurs due to the complexity of the its object of study and the fact that social and natural sciences are distinct and its not possible the replacement of one by another, making inconsistent to judge management by the natural sciences criteria. The second reason is related to the validity and relevance of the results obtained by management research, which makes that the researches require expanding their methodological rigor and present relevant contributions to the organizations management. In face of the highlighted and discussed aspects in this essay, it is defended the position that management can generate scientific knowledge, requiring, however, independently of epistemological position, to take more care of methodological rigor of studies in the area, so that their results are valid, as well to seek relevant contributions that improve the organizations management, considering that management has an applied nature.
O EMPREENDEDOR E A APLICAÇÃO DO SISTEMA DE CUSTEIO-ALVO EM PEQUENA EMPRESA DO SEGMENTO DE PLÁSTICO: UMA PESQUISA-AÇÃO
Authors: Faria Ana Cristina de , Freitas Luiz Henrique de , Marion José Carlos
Published: December 2015

Small business (SB’s) perform key role in national economy, but there are many difficulties to remain active in the market for long periods of time. This work emphasized the profile of the entrepreneur and the current status of SB in Brazil. One of the problems of these companies is how to manage (or not) costs, leading them sometimes to obtain damages in its operations. The aim was to verify, through action research, if the System of Target Costing generates economic and financial information timely and useful, is an innovative instrument for the management of costs and results of a small business’ entrepreneur. To develop the research, we tried to a small business run by entrepreneurs who, with a focus on managing its costs, agree to actively get involved in the research, cooperative and participatory as advocates for the methodology used. The information cleared from the application of the System of Target Costing in the company examined, which covered the values of the maximum cost to be incurred in each product and the need for reductions to achieve the target, were considered by partner-entrepreneurs as useful and timely because it is easy to investigation and interpretation, and innovative and strategic management of small business.
POSICIONAMENTO ESTRATÉGICO DOS AGENTES FOMENTADORES NA IMPLANTAÇÃO DA TV DIGITAL NO BRASIL: DISPUTAS, NEGOCIAÇÕES E ESTRATAGEMAS RETÓRICOS
Authors: Bazanini Roberto , Donato Mauricio , Donaire Denis , Ferreira Ademir Antonio
Published: December 2015

The quarrels on the model of implanted digital TV in Brazil in 02 of December of 2007, lasted thirteen years more than. In virtue of the dynamism of the debates, in the defense of its respective interests, the actors had been modifying its initial position in reply to a new rhetorical situation that to each new phase presented decurrent of the correlation of forces gifts in the environment. The objective of the work is in investigating the negotiations and the strategies of positioning used by the main involved agents in the process of implantation of the digital TV in Brazil and, concomitantly, to analyze and to argue the interests of each one of these actors envolved of the decision technique/politics of the choice of the standard of digital TV in the perspective of three theoretical referenciais: The Determined Strategy Continuously; The New Rhetoric and the Rhetorical Criticism. According with of exploratory research, qualitative nature, analysis after-factum, with job of instrument of collection of data directed toward content analysis, as Bardin considers (1997), the technique of the interview in depth next to the main Responsible Actors searched to confirm hypothesis proposal initially, according to which, the interests of the different groups in the implantation of the digital TV that made possible the choice of the Japanese standard causes small diversity the programming and minors possibilities of democratization of the communications. The results of the research point with respect to the adoption of the Japanese standard (in perfect accord with the interests of the Broadcasters and the Federal Government) in detriment of the interests of the civil society (searched the democratization) and of the Industry of Telecom (favorable to the European standard).
COMÉRCIO EXTERIOR E DESENVOLVIMENTO REGIONAL: A PROPOSTA DE UM CENTRO DE APOIO E INFORMAÇÃO COMO INSTRUMENTO MEDIADOR
Authors: Deboçã Leonardo Pinheiro , Silva Edson Arlindo , Nunes Daiane , Campos Dayane Aparecida Pereira , Kautuski Elaine Maria
Published: December 2015

This paper propose a support and information enterprise to foreign commerce (CENACE) in Associação dos Municípios do Centro do Paraná (AMOCENTRO) considering the viability conditions to these municipal districts that presents low Human Development Index. The search was realized by bibliographic and field method, with technical visits, interviews and indirect basis diagnosing the regional potential, in special way, related to farm production unexplored in foreign commerce. It has been discovered that there is a lack of information and professionals in the area of foreign commerce. In this context, it has been proposed a business plan, directed to AMOCENTRO, showing the viability conditions to the CENACE as a tool to the regional development.
Behind the Brow That Furrows
Authors: Aggarwal Neha
Published: September 2024

This essay describes the author’s observations while examining a pregnant mother who has multiple sclerosis.
Patterning Bacterial Cells on Quasi‐Liquid Surfaces for Biofilm Morphological Control
Authors: Chen Fangying , Boylan Dylan , Khan Fabiha Zaheen , Shan Li , Monga Deepak , Zimmern Philippe E. , Zhang Sulin , Palmer Kelli , Dai Xianming
Published: September 2024

Bacterial cells within biofilms exhibit resistance to antibiotics, presenting persistent health risks. Current approaches to inhibit biofilm formation have limitations due to their poor biofilm morphological control. For instance, bactericidal surfaces suffer from the accumulation of dead cells that compromise their antibacterial efficacy, and existing antifouling surfaces fail to inhibit biofilm formation. In this work, exceptional biofilm suppression is achieved on quasi‐liquid surfaces (QLS) with patterned surface chemistry where live bacterial cells are guided from slippery to sticky patterned destinations. These surfaces consist of 50 µm slippery and 10 µm sticky stripes. Live bacterial cells are directed to congregate on the sticky patterns, resulting in reduced biofilm biomass and surface coverage compared to uniform slippery surfaces. The patterned biofilm produces sparser extracellular matrix, thus reducing the barrier for antibiotic penetration and treatment. The innovative approach to direct cell migration on patterned QLS represents a promising strategy for inhibiting biofilm formation and combating biofilm‐associated infections.
The Doping Strategies for Modulation of Transport Properties in Thermoelectric Materials
Authors: Xiong Qihong , Han Guang , Wang Guoyu , Lu Xu , Zhou Xiaoyuan
Published: September 2024

Doping is a key method employed in semiconductor technology for tuning the carrier‐density‐dependent electrical properties. In thermoelectric materials, which are typically heavily doped semiconductors, more impact factors are needed to be considered due to the heavy dose doping compared to normal semiconductors beyond carrier concentration optimization, such as band structure modification, carrier scattering mechanism and even thermal transport property. In this review, the doping effect determined by the intrinsic band features and vice versa the influence of dopants on band structure is first illustrated; and then introduce the approaches to overcoming the dilemma in effective doping caused by the temperature‐dependent optimal carrier concentration. Second, the strategies including rational vacancy design, proper selection of dopants and lattice purification toward high efficient doping and weakened carrier scattering strength are reviewed. Third, the recent discovery of the effect of dopant on thermal transport is highlighted covering the dopant‐induced local lattice distortion and exceptional strong electron‐phonon coupling. Finally, a perspective is given for the doping strategies to further boost the performance of thermoelectric materials.
Multi‐Functional Ti3C2Tx‐Silver@Silk Nanofiber Composites With Multi‐Dimensional Heterogeneous Structure for Versatile Wearable Electronics
Authors: Yi Nuozhou , Zhang Cheng , Wang Zhen , Zheng Zhonghua , Zhou Jiahao , Shang Ruzhi , Zhou Peidi , Zheng Chan , You Minghua , Chen Huamin , Cheng Huanyu , Weng Mingcen
Published: September 2024

Silk nanofibers (SNFs) from abundant sources are low‐cost and environmentally friendly. Combined with other functional materials, SNFs can help create bioelectronics with excellent biocompatibility without environmental concerns. However, it is still challenging to construct an SNF‐based composite with high conductivity, flexibility, and mechanical strength for all SNF‐based electronics. Herein, this work reports the design and fabrication of Ti3C2Tx‐silver@silk nanofibers (Ti3C2Tx‐Ag@SNF) composites with multi‐dimensional heterogeneous conductive networks using combined in situ growth and vacuum filtration methods. The ultrahigh electrical conductivity of Ti3C2Tx‐Ag@SNF composites (142959 S m−1) provides the kirigami‐patterned soft heaters with a rapid heating rate of 87 °C s−1. The multi‐dimensional heterogeneous network further allows the creation of electromagnetic interference shielding devices with an exceptionally high specific shielding effectiveness of 10,088 dB cm−1. Besides working as a triboelectric layer to harvest the mechanical energy and recognize the hand gesture, the Ti3C2Tx‐Ag@SNF composites can also be combined with an ionic layer to result in a capacitive pressure sensor with a high sensitivity of 410 kPa−1 in a large range due to electronic‐double layer effect. The applications of the Ti3C2Tx‐Ag@SNF composites in recognizing human gestures and human‐machine interfaces to wirelessly control a trolley demonstrate the future development of all SNF‐based electronics.
Targeted Delivery of Circular Single‐Stranded DNA Encoding IL‐12 for the Treatment of Triple‐Negative Breast Cancer
Authors: Zhang Yijing , Cao Xisen , Hu Guang , Ye Rui , Zhang Li , Song Jie
Published: September 2024

Interleukin‐12 (IL‐12) is a critical cytokine with notable anticancer properties, including enhancing T‐cell‐mediated cancer cell killing, and curbing tumor angiogenesis. To date, many approaches are evaluated to achieve in situ overexpression of IL‐12, minimizing leakage and the ensuing toxicity. Here, it is focused on circular single‐stranded DNA (Css DNA), a type of DNA characterized by its unique structure, which could be expressed in mammals. It is discovered that Css DNA can induce sustained luciferase expression for half a year by intramuscular injection and showed effective antitumor results by intratumoral injection. Motivated by these findings, a folate‐modified LNP system is now developed for the delivery of Css DNA expressing IL‐12 for the therapy of 4T1 triple‐negative breast cancer (TNBC). This delivery system effectively activates anti‐cancer immune responses, slows tumor growth, significantly prolongs survival in animal models, and prevents tumor recurrence. After 6 months of long‐term observation, the elevated level of IL‐12 is still detectable in the lymph nodes and serum of the cured mice. This study highlights the long‐term sustained expression capacity of Css DNA and its ability to inhibit recurrence, and the potential of tumor‐targeted LNPs for Css DNA‐based cancer therapy, providing a new insight into gene overexpression strategy.
Novel Supramolecular Hydrogel for Infected Diabetic Foot Ulcer Treatment
Authors: Zhang Wenbiao , Wu Weiwei , Wang Tao , Wu Zhiwei , Li Yang , Ding Tao , Fang Zhennan , Tian Dasheng , He Xiaoyan , Huang Fei
Published: September 2024

Multifunctional responsive hydrogels hold significant promise for diabetic foot ulcer (DFU) treatment, though their complex design and manufacturing present challenges. This study introduces a novel supramolecular guanosine‐phenylboronic‐chlorogenic acid (GBC) hydrogel developed using a dynamic covalent strategy. The hydrogel forms through guanosine quadruplex assembly in the presence of potassium ions and chlorogenic acid (CA) linkage via dynamic borate bonds. GBC hydrogels exhibit pH and glucose responsiveness, releasing more chlorogenic acid under acidic and high glucose conditions due to borate bond dissociation and G‐quadruplex (G4) hydrogel disintegration. Experimental results indicate that GBC hydrogels exhibit good self‐healing, shear‐thinning, injectability, and swelling properties. Both in vitro and in vivo studies demonstrate the GBC hydrogel's good biocompatibility, ability to eliminate bacteria and reactive oxygen species (ROS), facilitate macrophage polarization from the M1 phenotype to the M2 phenotype (decreasing CD86 expression and increasing CD206 expression), exhibit anti‐inflammatory effects (reducing TNF‐α expression and increasing IL‐10 expression), and promote angiogenesis (increasing VEGF, CD31, and α‐SMA expression). Thus, GBC hydrogels accelerate DFU healing and enhance tissue remodeling and collagen deposition. This work provides a new approach to developing responsive hydrogels to expedite DFU healing.
Electro‐Optically Configurable Synaptic Transistors With Cluster‐Induced Photoactive Dielectric Layer for Visual Simulation and Biomotor Stimuli
Authors: Wang Xin , Zhang Liuyang , Zhao Yi , Qin Zongze , Hu Bin , Zhang Long , Jiang Yihang , Wang Qingyu , Liang Zechen , Tang Xian , Wu Jingpeng , Cao Fan , Bu Laju , Lei Bo , Lu Guanghao
Published: September 2024

The integration of visual simulation and biorehabilitation devices promises great applications for sustainable electronics, on‐demand integration and neuroscience. However, achieving a multifunctional synergistic biomimetic system with tunable optoelectronic properties at the individual device level remains a challenge. Here, an electro‐optically configurable transistor employing conjugated‐polymer as semiconductor layer and an insulating polymer (poly(1,8‐octanediol‐co‐citrate) (POC)) with clusterization‐triggered photoactive properties as dielectric layer is shown. These devices realize adeptly transition from electrical to optical synapses, featuring multiwavelength and multilevel optical synaptic memory properties exceeding 3 bits. Utilizing enhanced optical memory, the images learning and memory function for visual simulation are achieved. Benefiting from rapid electrical response akin to biological muscle activation, increased actuation occurs under increased stimulus frequency of gate voltage. Additionally, the transistor on POC substrate can be effectively degraded in NaOH solution due to degradation of POC. Pioneeringly, the electro‐optically configurability stems from light absorption and photoluminescence of the aggregation cluster in POC layer after 200 °C annealing. The enhancement of optical synaptic plasticity and integration of motion‐activation functions within a single device opens new avenues at the intersection of optoelectronics, synaptic computing, and bioengineering.
Ultrahigh Pyridinic/Pyrrolic N Enabling N/S Co‐Doped Holey Graphene with Accelerated Kinetics for Alkali‐Ion Batteries
Authors: Qin Meng , Chen Chi , Zhang Bohan , Yan Jun , Qiu Jieshan
Published: September 2024

Carbonaceous materials hold great promise for K‐ion batteries due to their low cost, adjustable interlayer spacing, and high electronic conductivity. Nevertheless, the narrow interlayer spacing significantly restricts their potassium storage ability. Herein, hierarchical N, S co‐doped exfoliated holey graphene (NSEHG) with ultrahigh pyridinic/pyrrolic N (90.6 at.%) and large interlayer spacing (0.423 nm) is prepared through micro‐explosion assisted thermal exfoliation of graphene oxide (GO). The underlying mechanism of the micro‐explosive exfoliation of GO is revealed. The NSEHG electrode delivers a remarkable reversible capacity (621 mAh g−1 at 0.05 A g−1), outstanding rate capability (155 mAh g−1 at 10 A g−1), and robust cyclic stability (0.005% decay per cycle after 4400 cycles at 5 A g−1), exceeding most of the previously reported graphene anodes in K‐ion batteries. In addition, the NSEHG electrode exhibits encouraging performances as anodes for Li‐/Na‐ion batteries. Furthermore, the assembled activated carbon||NSEHG potassium‐ion hybrid capacitor can deliver an impressive energy density of 141 Wh kg−1 and stable cycling performance with 96.1% capacitance retention after 4000 cycles at 1 A g−1. This work can offer helpful fundamental insights into design and scalable fabrication of high‐performance graphene anodes for alkali metal ion batteries.
Bimetal‐Biligand Frameworks for Spatiotemporal Nitric Oxide‐Enhanced Sono‐Immunotherapy
Authors: Cheng Yu , Zhong Wenbin , Chen Yun , Tan Brynne Shu Ni , Zhao Yue , Guo Jingjing , Ma Mengmeng , Zhao Yanli
Published: September 2024

Sonodynamic therapy can trigger immunogenic cell death to augment immunotherapy, benefiting from its superior spatiotemporal selectivity and non‐invasiveness. However, the practical applications of sonosensitizers are hindered by their low efficacy in killing cancer cells and activating immune responses. Here, two US Food and Drug Administration‐approved drug ligands (ferricyanide and nitroprusside) and two types of metals (copper/iron) are selected to construct a bimetal‐biligand framework (Cu[PBA‐NO]). Through elaborate regulation of multiple metal/ligand coordination, the systemically administered Cu[PBA‐NO] nanoagent shows sono‐catalytic and NO release ability under ultrasound irradiation, which can be used for effective sono‐immunotherapy. Moreover, Cu[PBA‐NO] can downregulate intracellular glutathione levels that would destroy intracellular redox homeostasis and facilitate reactive oxygen species accumulation. The released tumor‐associated antigens subsequently facilitate dendritic cell maturation within the tumor‐draining lymph node, effectively initiating a T cell‐mediated immune response and thereby bolstering the capacity to identify and combat cancer cells. This study paves a new avenue for the efficient cancer sono‐immunotherapy.
Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition
Authors: Wei Wuyang , Wang Hai , Ren Chunrong , Deng Ruxi , Qin Qiaoxi , Ding Li , Li Pan , Liu Ying , Chang Meiqi , Chen Yu , Zhou Yang
Published: September 2024

Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form of inflammatory programmed cell death, presents a dependable strategy for combating cancer by engaging multiple cell death pathways (apoptosis, pyroptosis, and necroptosis). In this study, an ultrasmall Bi2Sn2O7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties is designed and engineered as a PANoptosis inducer through destroying the mitochondrial function of tumor cells and enhancing the intracellular accumulation of toxic reactive oxygen species, finally triggering the activation of PANoptosis process. The role of PANoptosis inducer has been verified by the expression of related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, cleaved Caspase 1, p‐MLKL, and RIPK3. The inclusion of external ultrasonic irradiation significantly augments the enzyodynamic therapeutic efficiency. In vitro and in vivo antineoplastic efficacy, along with inhibition of lung metastasis, validate the benefits of the Bi2Sn2O7‐mediated PANoptosis pathway. This study not only elucidates the intricate mechanisms underlying Bi2Sn2O7 as a PANoptosis inducer, but also offers a novel perspective for the treatment of hepatocellular carcinoma.
Infrared Optical Anisotropy in Quasi‐1D Hexagonal Chalcogenide BaTiSe3
Authors: Zhao Boyang , Mei Hongyan , Du Zhengyu , Singh Shantanu , Chang Tieyan , Li Jiaheng , Ilyas Batyr , Song Qian , Liu Ting‐Ran , Shao Yu‐Tsun , Comin Riccardo , Gedik Nuh , Settineri Nicholas S. , Teat Simon J. , Chen Yu‐Sheng , Cronin Stephen B. , Kats Mikhail A. , Ravichandran Jayakanth
Published: September 2024

Polarimetric infrared (IR) detection bolsters IR thermography by leveraging the polarization of light. Optical anisotropy, i.e., birefringence and dichroism, can be leveraged to achieve polarimetric detection. Recently, giant optical anisotropy is discovered in quasi‐1D narrow‐bandgap hexagonal perovskite sulfides, A1+xTiS3, specifically BaTiS3 and Sr9/8TiS3. In these materials, the critical role of atomic‐scale structure modulations in the unconventional electrical, optical, and thermal properties raises the broader question of the nature of other materials that belong to this family. To address this issue, for the first time, high‐quality single crystals of a largely unexplored member of the A1+xTiX3 (X = S, Se) family, BaTiSe3 are synthesized. Single‐crystal X‐ray diffraction determined the room‐temperature structure with the P31c space group, which is a superstructure of the earlier reported P63/mmc structure. The crystal structure of BaTiSe3 features antiparallel c‐axis displacements similar to but of lower symmetry than BaTiS3, verified by the polarization dependent Raman spectroscopy. Fourier transform infrared (FTIR) spectroscopy is used to characterize the optical anisotropy of BaTiSe3, whose refractive index along the ordinary (E ⊥ c) and extraordinary (E ‖ c) optical axes is quantitatively determined by combining ellipsometry studies with FTIR. With a giant birefringence Δn ∼ 0.9, BaTiSe3 emerges as a new candidate for miniaturized birefringent optics for mid‐wave infrared to long‐wave infrared imaging.
Quantitative Decoupling of Strong Mn─Mn Coupling on Photoluminescence of Zero‐Dimensional Hybrid Manganese Chlorides Single Crystals
Authors: Luo Cheng , Li Juntao , Zhang Ruiling , Han Peigeng , Liu Jianyong , Yang Bin
Published: September 2024

Strong Mn─Mn coupling interactions, including dipolar and exchange interactions, significantly affect the photoluminescence quantum yields (PLQYs) in Mn2+‐based luminescent materials. However, clarifying the individual effects of dipole–dipole and exchange interactions on photoluminescence (PL) is challenging because these interactions may have similar effects on PL properties, and there is a lack of materials with precisely tunable Mn─Mn distances over a wide range. In this study, the influence of dipolar and exchange coupling on PLQY is quantitatively decoupled by designing a series of hybrid manganese chlorides single crystals with a wide tuning range of Mn─Mn distances, from 6.0 to 9.5 Å. It is found that the PLQY can be enhanced from 2.1% to 57.1%, and the PL lifetime increased from 0.21 to 3.81 ms as the Mn─Mn distance increased. This enhancement is solely attributed to the decreased energy transfer dominated by dipole–dipole interactions. At the shortest Mn─Mn distance of 6 Å, exchange coupling becomes dominant, resulting in an additional red‐side PL band with negligible effects on PLQY and lifetime. This work provides valuable insights into the mechanisms underlying the regulation of PLQY in Mn2⁺‐based luminescent materials.
2D WS2(Yb)/3D Te Mixed‐Dimensional Van der Waals p–p Heterostructure with High Optoelectronic Performance
Authors: Liu Shaoxiang , Liang Xianxiao , Zhao Yang , Feng Shuanglong , Shi Xuan , Zhao Hongquan
Published: September 2024

Mixed‐dimensional van der Waals heterostructures (vdWHs) have aroused extensive attention owing to distinctive properties by integrating advantages of materials with different types and dimensionalities for high‐performance optoelectronic devices. Herein, 2D Yb‐doped monolayer WS2 (WS2(Yb)) nanosheets and 3D bulk Te microwires are first prepared using chemical and physical vapor deposition (CVD/PVD) techniques, respectively. 12.7 at% of Yb‐doping concentration in WS2(Yb) matrix is achieved. Te microwires are transferred onto WS2(Yb) triangles by microarea fixed‐point dry transfer technique to form 2D WS2(Yb)/3D Te p–p heterostructures with a clean interface. Both p‐type semiconductors are shown for WS2(Yb) monolayer and bulk Te by calculating their band structures based on density functional theory (DFT), which is consistent with the experimental results. The optoelectronic device based on the WS2(Yb)/Te mixed‐dimensional vdWHs is fabricated using Au/Cr as the electrodes. Further, the photodetector demonstrates outstanding optoelectronic performance, including 1.87 A W−1 of responsivity, 366.7% of external quantum efficiency, and 2.53 × 1011 Jones of specific detectivity under illumination of a 635 nm light. Here a remarkable strategy is provided for preparation of mixed‐dimensional optoelectronic devices with high performances.
Transition Metal‐Derived 2D Layered Perovskites: A Promising Alternative to Pb in Photovoltaic Systems
Authors: Kalita Tanmoy , Das Pallab , Kalita Dhruba Jyoti
Published: September 2024

The high sensitivity of 3D perovskites toward air and moisture hampers their commercialization due to material decomposition. Introducing their 2D counterparts may provide a remedy to these stability issues, as hydrophobic bulky organic cations can resist direct contact of [ sheets with moisture in the air. In addition to air and water stability, 2D perovskites offer tunable optoelectronic properties through structural modulation, similar to their 3D counterparts. In this study, six different transition metal (TM)‐based 2D hybrid halide perovskites are designed: , , , , , and as alternatives for Pb‐based perovskites. Analysis of structural and thermodynamic parameters demonstrate that these designed perovskite materials can form structurally and thermodynamically stable compounds. Additionally, optical properties analysis reveals that the intended compounds exhibit absorption maxima in the visible range of the electromagnetic spectrum. Among the designed compounds, shows a promising power conversion efficiency (PCE) of 19.63%. Thus, these designed 2D perovskite materials hold potential as substitutes for conventional 3D materials in photovoltaic applications.
An Explainable Graph Neural Framework to Identify Cancer‐Associated Intratumoral Microbial Communities
Authors: Liu Zhaoqian , Sun Yuhan , Li Yingjie , Ma Anjun , Willaims Nyelia F. , Jahanbahkshi Shiva , Hoyd Rebecca , Wang Xiaoying , Zhang Shiqi , Zhu Jiangjiang , Xu Dong , Spakowicz Daniel , Ma Qin , Liu Bingqiang
Published: September 2024

Microbes are extensively present among various cancer tissues and play critical roles in carcinogenesis and treatment responses. However, the underlying relationships between intratumoral microbes and tumors remain poorly understood. Here, a MIcrobial Cancer‐association Analysis using a Heterogeneous graph transformer (MICAH) to identify intratumoral cancer‐associated microbial communities is presented. MICAH integrates metabolic and phylogenetic relationships among microbes into a heterogeneous graph representation. It uses a graph transformer to holistically capture relationships between intratumoral microbes and cancer tissues, which improves the explainability of the associations between identified microbial communities and cancers. MICAH is applied to intratumoral bacterial data across 5 cancer types and 5 fungi datasets, and its generalizability and reproducibility are demonstrated. After experimentally testing a representative observation using a mouse model of tumor‐microbe‐immune interactions, a result consistent with MICAH's identified relationship is observed. Source tracking analysis reveals that the primary known contributor to a cancer‐associated microbial community is the organs affected by the type of cancer. Overall, this graph neural network framework refines the number of microbes that can be used for follow‐up experimental validation from thousands to tens, thereby helping to accelerate the understanding of the relationship between tumors and intratumoral microbiomes.
Simultaneously Controlling Inflammation and Infection by Smart Nanomedicine Responding to the Inflammatory Microenvironment
Authors: Lv Xinjing , Min Jie , Huang Jie , Wang Hairong , Wei Song , Huang Chenxiao , Dai Jianfeng , Chen Zhengrong , Zhou Huiting , Xu Yunyun , Zhao He , Liu Zhuang , Wang Jian
Published: September 2024

The overactivated immune cells in the infectious lesion may lead to irreversible organ damages under severe infections. However, clinically used immunosuppressive anti‐inflammatory drugs will usually disturb immune homeostasis and conversely increase the risk of infections. Regulating the balance between anti‐inflammation and anti‐infection is thus critical in treating certain infectious diseases. Herein, considering that hydrogen peroxide (H2O2), myeloperoxidase (MPO), and neutrophils are upregulated in the inflammatory microenvironment and closely related to the severity of appendectomy patients, an inflammatory‐microenvironment‐responsive nanomedicine is designed by using poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles to load chlorine E6 (Ce6), a photosensitizer, and luminal (Lum), a chemiluminescent agent. The obtained Lum/Ce6@PLGA nanoparticles, being non‐toxic within normal physiological environment, can generate cytotoxic single oxygen via bioluminescence resonance energy transfer (BRET) in the inflammatory microenvironment with upregulated H2O2 and MPO, simultaneously killing pathogens and excessive inflammatory immune cells in the lesion, without disturbing immune homeostasis. As evidenced in various clinically relevant bacterial infection models and virus‐induced pneumonia, Lum/Ce6@PLGA nanoparticles appeared to be rather effective in controlling both infection and inflammation, resulting in significantly improved animal survival. Therefore, the BRET‐based nanoparticles by simultaneously controlling infections and inflammation may be promising nano‐therapeutics for treatment of severe infectious diseases.
Recognition and Sequencing of Mutagenic DNA Adduct at Single‐Base Resolution Through Unnatural Base Pair
Authors: Wang Honglei , Tie Wenchao , Zhu Wuyuan , Wang Shuyuan , Zhang Ruzhen , Duan Jianlin , Ye Bingyu , Zhu Anlian , Li Lingjun
Published: September 2024

DNA lesions are linked to cancer, aging, and various diseases. The recognition and sequencing of special DNA lesions are of great interest but highly challenging. In this paper, an unnatural‐base‐pair‐promoting method for sequencing highly mutagenic ethenodeoxycytidine (εC) DNA lesions that occurred frequently is developed. First, a promising unnatural base pair of dεC–dNaM to recognize εC lesions is identified, and then a conversion PCR is developed to site‐precise transfer dεC–dNaM to dTPT3–dNaM for convenient Sanger sequencing. The low sequence dependence of this method and its capacity for the enrichment of dεC in the abundance of as low as 1.6 × 10–6 nucleotides is also validated. Importantly, the current method can be smoothly applied for recognition, amplification, enrichment, and sequencing of the real biological samples in which εC lesions are generated in vitro or in vivo, thus offering the first sequencing methodology of εC lesions at single‐base resolution. Owing to its simple operations and no destruction of inherent structures of DNA, the unnatural‐base‐pair strategy may provide a new platform to produce general tools for the sequencing of DNA lesions that are hardly sequenced by traditional strategies.
Wafer‐Scale Replication of Plasmonic Nanostructures via Microbubbles for Nanophotonics
Authors: Hwang Jehwan , Zhang Yue , Kim Bongjoong , Jeong Jinheon , Yi Jonghun , Kim Dong Rip , Kim Young L. , Urbas Augustine , Ariyawansa Gamini , Xu Baoxing , Ku Zahyun , Lee Chi Hwan
Published: September 2024

Quasi‐3D plasmonic nanostructures are in high demand for their ability to manipulate and enhance light‐matter interactions at subwavelength scales, making them promising building blocks for diverse nanophotonic devices. Despite their potential, the integration of these nanostructures with optical sensors and imaging systems on a large scale poses challenges. Here, a robust technique for the rapid, scalable, and seamless replication of quasi‐3D plasmonic nanostructures is presented straight from their production wafers using a microbubble process. This approach not only simplifies the integration of quasi‐3D plasmonic nanostructures into a wide range of standard and custom optical imaging devices and sensors but also significantly enhances their imaging and sensing performance beyond the limits of conventional methods. This study encompasses experimental, computational, and theoretical investigations, and it fully elucidates the operational mechanism. Additionally, it explores a versatile set of options for outfitting nanophotonic devices with custom‐designed plasmonic nanostructures, thereby fulfilling specific operational criteria.