bluuebunny/crossref_metadata_2025 huggingface dataset:
The association between isometric strength and cognitive function in adults with cerebral palsy
Authors: Heyn Patricia C. , Tagawa Alex , Pan Zhaoxing , Reistetter Timothy , Ng Ted Kheng Siang , Lewis Meredith , Carollo James J.
Published: April 2023

Background

The literature supports quantifying the maximum force/tension generated by one’s forearm muscles such as the hand grip strength (HGS) to screen for physical and cognitive frailty in older adults. Thus, we postulate that individuals with cerebral palsy (CP), who are at higher risk for premature aging, could benefit from tools that objectively measure muscle strength as a functional biomarker to detect frailty and cognitive decline. This study assesses the clinical relevancy of the former and quantifies isometric muscle strength to determine its association with cognitive function in adults with CP.

Methods

Ambulatory adults with CP were identified from a patient registry and were enrolled into this study. Peak rate of force development (RFD) and maximum voluntary isometric contraction of the quadriceps were measured using a commercial isokinetic machine, while HGS was collected with a clinical dynamometer. Dominant and non-dominant side were identified. Standardized cognitive assessments, including the Wechsler Memory and Adult Intelligence Scales IV, Short Test of Mental Status, and the Patient-Reported Outcomes Measurement Information System (PROMIS®) were used to evaluate cognitive function.

Results

A total of 57 participants (32 females; mean age 24.3 [SD 5.3]; GMFCS levels I–IV) were included in the analysis. Although dominant and non-dominant RFD and HGS measures were associated with cognitive function, non-dominant peak RFD showed the strongest associations with cognitive function.

Conclusion

RFD capacity may reflect age-related neural and physical health and could be a better health indicator than HGS in the CP population.
Cancer-related fatigue classification based on heart rate variability signals from wearables
Authors: Shih Chi-Huang , Chou Pai-Chien , Chen Jin-Hua , Chou Ting-Ling , Lai Jun-Hung , Lu Chi-Yu , Huang Tsai-Wei
Published: April 2023

Background

Cancer-related fatigue (CRF) is the most distressing side effect in cancer patients and affects the survival rate. However, most patients do not report their fatigue level. This study is aimed to develop an objective CRF assessment method based on heart rate variability (HRV).

Methods

In this study, patients with lung cancer who received chemotherapy or target therapy were enrolled. Patients wore wearable devices with photoplethysmography that regularly recorded HRV parameters for seven consecutive days and completed the Brief Fatigue Inventory (BFI) questionnaire. The collected parameters were divided into the active and sleep phase parameters to allow tracking of fatigue variation. Statistical analysis was used to identify correlations between fatigue scores and HRV parameters.

Findings

In this study, 60 patients with lung cancer were enrolled. The HRV parameters including the low-frequency/high-frequency (LF/HF) ratio and the LF/HF disorder ratio in the active phase and the sleep phase were extracted. A linear classifier with HRV-based cutoff points achieved correct classification rates of 73 and 88% for mild and moderate fatigue levels, respectively.

Conclusion

Fatigue was effectively identified, and the data were effectively classified using a 24-h HRV device. This objective fatigue monitoring method may enable clinicians to effectively handle fatigue problems.
Dendritic cell proliferation by primary cilium in atopic dermatitis
Authors: Toriyama Manami , Rizaldy Defri , Nakamura Motoki , Atsumi Yukiko , Toriyama Michinori , Fujita Fumitaka , Okada Fumihiro , Morita Akimichi , Itoh Hiroshi , Ishii Ken J.
Published: April 2023

Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in disease remain unclear.

Methods: We performed immunostaining on human skin and peripheral blood mononuclear cells (PBMCs) and visualized primary cilium.

Result and discussion: We show that human dendritic cells (DCs) and LCs have a previously unknown primary cilium-like structure. The primary cilium was assembled during DC proliferation in response to the Th2 cytokine GM-CSF, and its formation was halted by DC maturation agents. This suggests that the role of primary cilium is to transduce proliferation signaling. The platelet-derived growth factor receptor alpha (PDGFRα) pathway, which is known for transducing proliferation signals in the primary cilium, promoted DC proliferation in a manner dependent on the intraflagellar transport (IFT) system. We also examined the epidermal samples from AD patients, and observed aberrantly ciliated LCs and keratinocytes in immature and proliferating states. Our results identify a potential relationship between the primary cilium and allergic skin barrier disorders, and suggest that targeting the primary cilium may contribute to treating AD.
Gout and risk of dementia, Alzheimer's disease or vascular dementia: a meta-epidemiology study
Authors: Li Xuanlin , Huang Lin , Tang Yujun , Hu Xuanming , Wen Chengping
Published: April 2023

Objectives

The association between gout and dementia, Alzheimer's disease (AD), or vascular dementia (VD) is not fully understood. The aim of this meta-analysis was to evaluate the risk of all-cause dementia, AD, and VD in gout patients with or without medication.

Methods

Data sources were PubMed, Embase, the Cochrane Library, and reference lists of included studies. This meta-analysis included cohort studies assessing whether the risk of all-cause dementia, AD, and VD was associated with gout. The risk of bias was assessed using the Newcastle-Ottawa Quality Assessment Scale (NOS). The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system was used to access the overall certainty of evidence. Risk ratios (RR) with 95% confidence intervals (CI) were pooled using a random-effects model, and publication bias was assessed with funnel plots and Egger's test.

Results

A total of six cohort studies involving 2,349,605 individuals were included in this meta-analysis, which were published between 2015 and 2022. The pooling analysis shows that the risk of all-cause dementia was decreased in gout patients [RR = 0.67, 95% CI (0.51, 0.89), I2 = 99%, P = 0.005, very low quality], especially in gout patients with medication [RR = 0.50, 95% CI (0.31, 0.79), I2 = 93%, P = 0.003, low quality]. The risk of AD [RR = 0.70, 95% CI (0.63, 0.79), I2 = 57.2%, P = 0.000, very low quality] and VD [RR = 0.68, 95% CI (0.49, 0.95), I2 = 91.2%, P = 0.025, very low quality] was also decreased in gout patients. Despite the large heterogeneity, the sensitivity analysis indicated that the results were robust, and there was little evidence of publication bias.

Conclusion

The risk of all-cause dementia, AD, and VD is decreased in gout patients, but the quality of evidence is generally low. More studies are still needed to validate and explore the mechanisms of this association.

Systematic review registration

https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022353312.
Impact of cardiac surgery associated acute kidney injury on 1-year major adverse kidney events
Authors: Molina Andújar Alícia , Escudero Victor Joaquin , Piñeiro Gaston J. , Lucas Alvaro , Rovira Irene , Matute Purificación , Ibañez Cristina , Blasco Miquel , Quintana Luis F. , Sandoval Elena , Sánchez Marina Chorda , Quintana Eduard , Poch Esteban
Published: April 2023

Background

The incidence of acute kidney injury following cardiac surgery (CSA-AKI) is up to 30%, and the risk of chronic kidney disease (CKD) has been found to be higher in these patients compared to the AKI-free population. The aim of our study was to assess the risk of major adverse kidney events (MAKE) [25% or greater decline in estimated glomerular filtration rate (eGFR), new hemodialysis, and death] after cardiac surgery in a Spanish cohort and to evaluate the utility of the score developed by Legouis D et al. (CSA-CKD score) in predicting the occurrence of MAKE.

Methods

This was a single-center retrospective study of patients who required cardiac surgery with cardiopulmonary bypass (CPB) during 2015, with a 1-year follow-up after the intervention. The inclusion criteria were patients over 18 years old who had undergone cardiac surgery [i.e., valve substitution (VS), coronary artery bypass graft (CABG), or a combination of both procedures].

Results

The number of patients with CKD (eGFR < 60 mL/min) increased from 74 (18.3%) to 97 (24%) within 1 year after surgery. The median eGFR declined from 85 to 82 mL/min in the non-CSA-AKI patient group and from 73 to 65 mL/min in those with CSA-AKI (p = 0.024). Fifty-eight patients (1.4%) presented with MAKE at the 1-year follow-up. Multivariate logistic regression analysis showed that the only variable associated with MAKE was CSA-AKI [odds ratio (OR) 2.386 (1.31–4.35), p = 0.004]. The median CSA-CKD score was higher in the MAKE cohort [3 (2–4) vs. 2 (1–3), p < 0.001], but discrimination was poor, with a receiver operating characteristic curve (AUC) value of 0.682 (0.611–0.754).

Conclusion

Any-stage CSA-AKI is associated with a risk of MAKE after 1 year. Further research into new measures that identify at-risk patients is needed so that appropriate patient follow-up can be carried out.
The application of SUDEP in forensic diagnosis: a mini review
Authors: Sun Daming , Wang Qiang
Published: April 2023

In the epilepsy population, the risk of sudden death from epilepsy is rare but is ~24 times greater than the risk of sudden death from other causes. Sudden unexpected death in epilepsy (SUDEP) has been widely recognized in clinical studies. Despite its significance as a cause of death, SUDEP is rarely used in forensic practice. This review focuses on the forensic characteristics of SUDEP, analyzed the reasons for its underuse in forensic practice, and illustrated the prospect of establishing uniform diagnostic criteria for sudden unexpected death in epilepsy and molecular anatomy in aiding forensic diagnosis.
Deep learning-based electroencephalic diagnosis of tinnitus symptom
Authors: Hong Eul-Seok , Kim Hyun-Seok , Hong Sung Kwang , Pantazis Dimitrios , Min Byoung-Kyong
Published: April 2023

Tinnitus is a neuropathological phenomenon caused by the recognition of external sound that does not actually exist. Existing diagnostic methods for tinnitus are rather subjective and complicated medical examination procedures. The present study aimed to diagnose tinnitus using deep learning analysis of electroencephalographic (EEG) signals while patients performed auditory cognitive tasks. We found that, during an active oddball task, patients with tinnitus could be identified with an area under the curve of 0.886 through a deep learning model (EEGNet) using EEG signals. Furthermore, using broadband (0.5 to 50 Hz) EEG signals, an analysis of the EEGNet convolutional kernel feature maps revealed that alpha activity might play a crucial role in identifying patients with tinnitus. A subsequent time-frequency analysis of the EEG signals indicated that the tinnitus group had significantly reduced pre-stimulus alpha activity compared with the healthy group. These differences were observed in both the active and passive oddball tasks. Only the target stimuli during the active oddball task yielded significantly higher evoked theta activity in the healthy group compared with the tinnitus group. Our findings suggest that task-relevant EEG features can be considered as a neural signature of tinnitus symptoms and support the feasibility of EEG-based deep-learning approach for the diagnosis of tinnitus.
Genetic alterations in peritoneal metastatic tumors predicted the outcomes for hyperthermic intraperitoneal chemotherapy
Authors: Nguyen Quynh-Anh , Chou Wan-Hsuan , Hsieh Mao-Chih , Chang Che-Mai , Luo Wei-Tzu , Tai Yu-Ting , Chang Wei-Chiao
Published: April 2023

Introduction

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are considered for patients with peritoneal metastasis (PM). However, patients selection that relies on conventional prognostic factors is not yet optimal. In this study, we performed whole exome sequencing (WES) to establish tumor molecular characteristics and expect to identify prognosis profiles for PM management.

Methods

In this study, blood and tumor samples were collected from patients with PM before HIPEC. Tumor molecular signatures were determined using WES. Patient cohort was divided into responders and non-responders according to 12-month progression-free survival (PFS). Genomic characteristics between the two cohorts were compared to study potential targets.

Results

In total, 15 patients with PM were enrolled in this study. Driver genes and enriched pathways were identified from WES results. AGAP5 mutation was found in all responders. This mutation was significantly associated with better OS (p = 0.00652).

Conclusions

We identified prognostic markers that might be useful to facilitate decision-making before CRS/HIPEC.
Optimizing the structure of interdisciplinary tumor boards for effective cancer care
Authors: Braulke Friederike , Kober Kathrin , Arndt Andreas , Papendick Maximilian , Strauss Arne , Kramm Christof Maria , Thoms Kai-Martin , König Alexander , Gaedcke Jochen , Gallwas Julia , Wulf Svenja , Szuszies Christoph , Wulf Gerald , Rödel Ralph , Wolfer Susanne , Malinova Vesna , Overbeck Tobias R. , Hinterthaner Marc , Lotz Joachim , Nauck Friedemann , Ernst Marielle , Stadelmann Christine , Ströbel Philipp , Ellenrieder Volker , Asendorf Thomas , Rieken Stefan
Published: April 2023

Introduction

Multi-professional interdisciplinary tumor boards (ITB) are essential institutions to discuss all newly diagnosed, relapsed or complex cancer patients in a team of specialists to find an optimal cancer care plan for each individual patient with regard to national and international clinical practice guidelines, patient´s preference and comorbidities. In a high-volume cancer center, entity-specific ITBs take place at least once a week discussing a large number of patients. To a high level of expertise and dedication, this also requires an enormous amount of time for physicians, cancer specialists and administrative support colleagues, especially for radiologists, pathologists, medical oncologists and radiation oncologists, who must attend all cancer-specific boards according to certification requirements.

Methods

In this 15-month prospective German single-center analysis, we examined the established structures of 12 different cancer-specific ITBs at the certified Oncology Center and demonstrate tools helping to optimize processes before, during and after the boards for optimal, time-saving procedures.

Results

By changing pathways, introducing revised registration protocols and new digital supports we could show that the workload of preparation by radiologists and pathologists could be reduced significantly by 22.9% (p=<0.0001) and 52.7% (p=<0.0001), respectively. Furthermore, two questions were added to all registration forms about the patient´s need for specialized palliative care support that should lead to more awareness and early integration of specialized help.

Discussion

There are several ways to reduce the workload of all ITB team members while maintaining high quality recommendations and adherence to national and international guidelines.
Multi-b-value diffusion stretched-exponential model parameters correlate with MIB-1 and CD34 expression in Glioma patients, an intraoperative MR-navigated, biopsy-based histopathologic study
Authors: Wang Junlong , Zhang Hua , Dang Xuefei , Rui Wenting , Cheng Haixia , Wang Jing , Zhang Yong , Qiu Tianming , Yao Zhenwei , Liu Hanqiu , Pang Haopeng , Ren Yan
Published: April 2023

Background

To understand the pathological correlations of multi-b-value diffusion-weighted imaging (MDWI) stretched-exponential model (SEM) parameters of α and diffusion distribution index (DDC) in patients with glioma. SEM parameters, as promising biomarkers, played an important role in histologically grading gliomas.

Methods

Biopsy specimens were grouped as high-grade glioma (HGG) or low-grade glioma (LGG). MDWI-SEM parametric mapping of DDC1500, α1500 fitted by 15 b-values (0-1,500 sec/mm2)and DDC5000 and α5000 fitted by 22 b-values (0-5,000 sec/mm2) were matched with pathological samples (stained by MIB-1 and CD34) by coregistered localized biopsies, and all SEM parameters were correlated with these pathological indices pMIB-1(percentage of MIB-1 expression positive rate) and CD34-MVD (CD34 expression positive microvascular density for each specimen). The two-tailed Spearman’s correlation was calculated for pathological indexes and SEM parameters, as well as WHO grades and SEM parameters.

Results

MDWI-derived α1500 negatively correlated with CD34-MVD in both LGG (6 specimens) and HGG (26 specimens) (r=-0.437, P =0.012). MDWI-derived DDC1500 and DDC5000 negatively correlated with MIB-1 expression in all glioma patients (P<0.05). WHO grades negatively correlated with α1500(r=-0.485; P=0.005) and α5000(r=-0.395; P=0.025).

Conclusions

SEM-derived DDC and α are significant in histologically grading gliomas, DDC may indicate the proliferative ability, and CD34 stained microvascular perfusion may be an important determinant of water diffusion inhomogeneity α in glioma.
Diseases of the musculoskeletal system and connective tissue and risk of breast cancer: Mendelian randomization study in European and East Asian populations
Authors: Xu Yue-chen , Wang Jian-xiong , Chu Yi-ran , Qian Han , Wang Hong-yan , Wang Fan
Published: April 2023

Objective

Associations between diseases of the musculoskeletal system and connective tissue (MSCTD) and breast cancer (BC) have not been elucidated completely. The purpose of this study was to investigate the associations of MSCTD, rheumatoid arthritis (RA), Sjogren syndrome (SS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis (DM), polymyositis (PM), osteoarthritis (OA) of hip or knee, and ankylosing spondylitis (AS) with BC in European populations and East Asian populations using Mendelian randomized (MR) analysis.

Methods

The genetic instruments linked to MSCTD, RA, SS, SLE, SSc, DM, PM, OA, and AS were chosen from the EBI database of complete genome-wide association studies (GWAS) summary data and the FinnGen consortium. The associations of genetic variants with BC were extracted from the Breast Cancer Association Consortium (BCAC). Two Sample MR was performed using summary data from GWAS, principally using the inverse variant weighted (IVW) method. Heterogeneity, pleiotropy, and sensitivity analyses were performed to evaluate the robustness of the results by weighted median, MR Egger, simple mode, weighted mode, and leave-one-out analysis.

Results

In the European population, causal relationships between RA and BC (OR=1.04, 95%CI: 1.01-1.07, P=0.023), AS and BC (OR=1.21, 95%CI: 1.06-1.36, P=0.013) were confirmed. IVW analysis showed DM (OR=0.98, 95%CI: 0.96-0.99, P=0.026) and PM (OR=0.98, 95%CI: 0.97-0.99, P=0.002) were associated with slightly decreased risks of estrogen receptor (ER)+ BC, and MSCTD was associated with an increased risk of ER- BC (OR=1.85, 95%CI: 1.27-2.44, P=0.039). There was no causal relationship between SLE, SS, SSc, OA, and BC, neither ER+ BC nor ER- BC. However, in the East Asian population, IVW analysis showed that RA (OR=0.94, 95%CI: 0.89-0.99, P=0.0096) and SLE (OR=0.95, 95%CI: 0.92-0.99, P=0.0058) was associated with decreased risks of BC.

Conclusions

This study suggests that causal relationships between patients with MSCTD and BC in the European population are different from those in the East Asian population, patients with RA and AS in the European population have an increased risk of BC, patients with MSCTD have increased risk of ER- BC in the European population, while patients with RA and SLE in the East Asian population have decreased risk of BC.
A super-voxel-based method for generating surrogate lung ventilation images from CT
Authors: Chen Zhi , Huang Yu-Hua , Kong Feng-Ming , Ho Wai Yin , Ren Ge , Cai Jing
Published: April 2023

Purpose: This study aimed to develop and evaluate CTVISVD, a super-voxel-based method for surrogate computed tomography ventilation imaging (CTVI).

Methods and Materials: The study used four-dimensional CT (4DCT) and single-photon emission computed tomography (SPECT) images and corresponding lung masks from 21 patients with lung cancer obtained from the Ventilation And Medical Pulmonary Image Registration Evaluation dataset. The lung volume of the exhale CT for each patient was segmented into hundreds of super-voxels using the Simple Linear Iterative Clustering (SLIC) method. These super-voxel segments were applied to the CT and SPECT images to calculate the mean density values (Dmean) and mean ventilation values (Ventmean), respectively. The final CT-derived ventilation images were generated by interpolation from the Dmean values to yield CTVISVD. For the performance evaluation, the voxel- and region-wise differences between CTVISVD and SPECT were compared using Spearman’s correlation and the Dice similarity coefficient index. Additionally, images were generated using two deformable image registration (DIR)-based methods, CTVIHU and CTVIJac, and compared with the SPECT images.

Results: The correlation between the Dmean and Ventmean of the super-voxel was 0.59 ± 0.09, representing a moderate-to-high correlation at the super-voxel level. In the voxel-wise evaluation, the CTVISVD method achieved a stronger average correlation (0.62 ± 0.10) with SPECT, which was significantly better than the correlations achieved with the CTVIHU (0.33 ± 0.14, p < 0.05) and CTVIJac (0.23 ± 0.11, p < 0.05) methods. For the region-wise evaluation, the Dice similarity coefficient of the high functional region for CTVISVD (0.63 ± 0.07) was significantly higher than the corresponding values for the CTVIHU (0.43 ± 0.08, p < 0.05) and CTVIJac (0.42 ± 0.05, p < 0.05) methods.

Conclusion: The strong correlation between CTVISVD and SPECT demonstrates the potential usefulness of this novel method of ventilation estimation for surrogate ventilation imaging.
Metabolic cost of osmoregulation by the gastro-intestinal tract in marine teleost fish
Authors: Little A. , Pasparakis C. , Stieglitz J. , Grosell M.
Published: April 2023

Introduction: Although dozens of studies have attempted to determine the metabolic cost of osmoregulation, mainly by comparing standard metabolic rates (SMR) in fish acclimated to different salinities, consensus is still lacking.

Methods: In the present study, using the Gulf toadfish, Opsanus beta, we aimed to determine the metabolic cost of esophageal and intestinal osmoregulatory processes by estimating ATP consumption from known ion transport rates and pathways and comparing these estimates with measurements on isolated tissues. Further, we performed whole animal respirometry on fish acclimated to 9, 34 and 60 ppt.

Results and Discussion: Our theoretical estimates of esophageal and intestinal osmoregulatory costs were in close agreement with direct measurements on isolated tissues and suggest that osmoregulation by these tissues amounts to ∼2.5% of SMR. This value agrees well with an earlier attempt to estimate osmoregulation cost from ion transport rates and combined with published measurements of gill osmoregulatory costs suggests that whole animal costs of osmoregulation in marine teleosts is ∼7.5% of SMR. As in many previous studies, our whole animal measurements were variable between fish and did not seem suited to determine osmoregulatory costs. While the esophagus showed constant metabolic rate regardless of acclimation salinity, the intestine of fish acclimated to higher salinities showed elevated metabolic rates. The esophagus and the intestine had 2.1 and 3.2-fold higher metabolic rates than corresponding whole animal mass specific rates, respectively. The intestinal tissue displays at least four different Cl− uptake pathways of which the Na+:Cl−:2 K+ (NKCC) pathway accounts for 95% of the Cl− uptake and is the most energy efficient. The remaining pathways are via apical anion exchange and seem to primarily serve luminal alkalinization and the formation of intestinal CaCO3 which is essential for water absorption.
More flexible and more innovative: the impact of flexible work arrangements on the innovation behavior of knowledge employees
Authors: Jiang Liqun , Pan Zhiyuan , Luo Yunshi , Guo Ziyan , Kou Deqiang
Published: April 2023

Flexible work arrangements (FWA) are becoming increasingly widespread as an efficient means of coping with a dynamic and competitive business environment. Existing studies have primarily examined the impact of FWA as a management system; however, its impact on employee innovation behavior has not been fully explored. Based on the self-determination theory, this study constructed a moderated mediation model that empirically examined the influence of FWA on the innovation behavior of knowledge employees. Our findings are as follows: (1) FWA can activate innovation behavior among knowledge employees; (2) thriving at work plays a partial mediating role; (3) human resource policies that facilitate opportunities have a positive moderating effect. The findings fill a theoretical research gap and provide insights for managers on implementing FWA to promote the innovative behavior of knowledge employees.
Undercompression errors as evidence for conceptual primitives
Authors: Guasti Maria Teresa , Alexiadou Artemis , Sauerland Uli
Published: April 2023

The Meaning First Approach offers a model of the relation between thought and language that includes a Generator and a Compressor. The Generator build non-linguistic thought structures and the Compressor is responsible for its articulation through three processes: structure-preserving linearization, lexification, and compression via non-articulation of concepts when licensed. One goal of this paper is to show that a range of phenomena in child language can be explained in a unified way within the Meaning First Approach by the assumption that children differ from adults with respect to compression and, specifically, that they may undercompress in production, an idea that sets a research agenda for the study of language acquisition. We focus on dependencies involving pronouns or gaps in relative clauses and wh-questions, multi-argument verbal concepts, and antonymic concepts involving negation or other opposites. We present extant evidence from the literature that children produce undercompression errors (a type of commission errors) that are predicted by the Meaning First Approach. We also summarize data that children’s comprehension ability provides evidence for the Meaning First Approach prediction that decompression should be challenging, when there is no 1-to-1 correspondence.
Happiness and mental health of older adults: multiple mediation analysis
Authors: Sun Yujin
Published: April 2023

Introduction

This study aims to explore the influence mechanism of older adult mental health. As the aging population grows, the mental health of older adults becomes a significant public health and social issue, with happiness serving as a key dimension of mental health.

Methods

This study utilizes public data from CGSS to investigate the relationship between happiness and mental health, with Process V4.1 used for mediating effects analysis.

Results

The findings suggest a positive predictive effect of happiness on mental health, with three mediating paths identified: independent mediating effect paths of income satisfaction and health, as well as a multiple mediating effects path through income satisfaction and health.

Discussion

The study suggests that improving the multi-subject mental health support service system for older adults and creating public values for mental health risk coping mechanisms. This helps to understand the complex relationship between aging on individual and social levels. These results provide empirical support for healthy aging among older adults and future policymaking.
Cues to deception: can complications, common knowledge details, and self-handicapping strategies discriminate between truths, embedded lies and outright lies in an Italian-speaking sample?
Authors: Caso Letizia , Cavagnis Lucrezia , Vrij Aldert , Palena Nicola
Published: April 2023

Deception research has shown that analysing verbal content can be effective to distinguish between truths and lies. However, most verbal cues are cues to truthfulness (truth tellers report the cue more than lie tellers), whereas cues to deception (lie tellers report the cue more than truth tellers) are largely absent. The complication approach, measuring complications (cue to truthfulness), common knowledge details (cue to deception), self-handicapping strategies (cue to deception), and the ratio of complications, aims to fill this gap in the literature. The present experiment examined the effectiveness of the complication approach when varying the amount of lying, with an Italian sample. Seventy-eight participants were assigned to one of three different experimental conditions: Truth tellers (telling the truth about the event), embedders (providing a mixture of truthful and false information) and outright lie tellers (providing false information). Participants were interviewed about a past experience concerning an out of the ordinary event. Complications discriminated truth tellers from lie tellers. The absence of significant effects for common knowledge details and self-handicapping strategies, the limitations of the experiment and suggestions for future research are discussed.
Literacy-related differences in morphological knowledge: A nonce-word study
Authors: Dąbrowska Ewa , Pascual Esther , Macías-Gómez-Estern Beatriz , Llompart Miquel
Published: April 2023

Using a nonce-word inflection task, we examine the morphosyntactic productivity of adult native speakers of Spanish who are either beginning to learn to read and write (semi-literates) or have acquired literacy in late adulthood (late-literates), as well as age-matched controls (high-literates). High-literates consistently provided the appropriate form more often than late-literates, who in turn were better than semi-literate participants. Crucially, group interacted with person, number, and conjugation, such that the between-group differences were larger for the less frequent cells in the paradigm, indicating that literacy-related differences are not merely a consequence of the high-literacy group being more engaged or test-wise. This suggests that the availability of written representations may facilitate the acquisition of certain aspects of grammar. We also observed vast individual differences in productivity with inflectional endings. These results add to the growing body of research which challenges the assumption that all native speakers converge on the same grammar early in development.
Local field potentials in major depressive and obsessive-compulsive disorder: a frequency-based review
Authors: Zhang Wei , Xiong Botao , Wu Yang , Xiao Linglong , Wang Wei
Published: April 2023

Objectives

The purpose of this paper is to provide a mini-review covering the recent progress in human and animal studies on local field potentials (LFPs) of major depressive disorder (MDD) and obsessive-compulsive disorder (OCD).

Materials and methods

PubMed and EMBASE were searched to identify related studies. Inclusion criteria were (1) reported the LFPs on OCD or MDD, (2) published in English, and (3) human or animal studies. Exclusion criteria were (1) review or meta-analysis or other literature types without original data and (2) conference abstract without full text. Descriptive synthesis of data was performed.

Results

Eight studies on LFPs of OCD containing 22 patients and 32 rats were included: seven were observational studies with no controls, and one animal study included a randomized and controlled phase. Ten studies on LFPs of MDD containing 71 patients and 52 rats were included: seven were observational studies with no controls, one study with control, and two animal studies included a randomized and controlled phase.

Conclusion

The available studies revealed that different frequency bands were associated with specific symptoms. Low frequency activity seemed to be closely related to OCD symptoms, whereas LFPs findings in patients with MDD were more complicated. However, limitations of recent studies restrict the drawing of definite conclusions. Combined with other measures such as Electroencephalogram, Electrocorticography, or Magnetoencephalography and long-term recordings in various physiological states (rest state, sleep state, task state) could help to improve the understanding of potential mechanisms.
COVID-19 pandemic-related depression and anxiety under lockdown: The chain mediating effect of self-efficacy and perceived stress
Authors: Sun Luna , Wang Xiaoran , Hong Yi , Li Chaoran , Zeng Wenfeng , Liu Peng , Xiong Yani , Chen Yanping , Lian Yongjie , Wang Yunxia
Published: April 2023

Objective

In early March 2022, the highly contagious Omicron variant rapidly emerged in Shanghai. This study aimed to explore the prevalence and associated factors of depression and anxiety in isolated or quarantined populations under lockdown.

Methods

A cross-sectional study was conducted between May 12 and 25, 2022. The depressive and anxiety symptoms, perceived stress, self-efficacy and perceived social support in the 167 participants under isolated or quarantined were examined using the Patient Health Questionnaires-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Perceived Stress Scale-10 (PSS-10), the General Self-Efficacy Scale (GSES) and the Perceived Social Support Scale (PSSS). Data on demographic information were also collected.

Findings

The prevalence of depression and anxiety in isolated or quarantined populations was estimated to be 12 and 10.8%, respectively. Higher education level, being healthcare workers, being infected, longer duration of segregation and higher perceived stress level were identified as risk factors for depression and anxiety. Furthermore, the relationship between perceived social support and depression (anxiety) was mediated not only by perceived stress but also the chain of self-efficacy and perceived stress.

Conclusion

Being infected, higher education level, longer duration of segregation and higher perceived stress were associated with higher levels of depression and anxiety among isolated or quarantined populations under lockdown. The formulation of psychological strategies that promote one’s perceived social support and self-efficacy as well as reduce perceived stress is supposed to be drawn.
Case report: Treatment-resistant depression, multiple trauma exposure and suicidality in an adolescent female with previously undiagnosed Autism Spectrum Disorder
Authors: Secci Ilaria , Petigas Lucie , Cuenod Alexandra , Klauser Paul , Kapp Carole , Novatti Audrey , Armando Marco
Published: April 2023

High rates of co-occurring depression are commonly reported in youth with Autism Spectrum Disorder (ASD), especially in individuals without intellectual disability (ID). Depression in ASD undermines adaptive behavior and is associated with a higher risk of suicidality. Females with ASD may be particularly vulnerable due to their greater use of camouflaging strategies. Indeed, in comparison to males, ASD is underdiagnosed in females, despite higher rates of internalizing symptoms and suicidality. Trauma exposure may also play a role in the development of depressive symptoms in this population. Moreover, evidence for effective treatments of depression in autistic youth are lacking, with ASD individuals frequently experiencing low efficacy and side effects. We present the case of an adolescent female with previously undiagnosed ASD without ID, admitted for active suicidal plans and a treatment-resistant depression (TRD), occurred after a COVID-19 lockdown in the context of cumulative exposure to stressful life events. Comprehensive clinical assessments performed at intake confirmed severe depression with suicidality. Intensive psychotherapy and different changes in medications were carried out (SSRI, SNRI, SNRI + NaSSA, SNRI + aripiprazole), all of which were ineffective, with persistent suicidal thoughts, often requiring intensive individual monitoring. The patient was finally successfully treated with lithium augmentation of fluoxetine, with no side effects. During hospitalization she was also evaluated by an ASD specialized center, where a diagnosis of ASD was made according to the Autism Diagnostic Observation Schedule (ADOS) and the Autism Diagnostic Interview-Revised (ADI-R) scores, as well as to clinical judgment of a senior psychiatrist. The present case report shows that clinicians should not overlook undiagnosed autism as a possible cause of TRD, especially in females without ID, where higher rates of under diagnosis may be in part related to their greater use of camouflage. It also suggests that ASD underdiagnosis and resulting unmet needs may be involved in vulnerability to stressful experiences, depression, and suicidality. Furthermore, it shows the complexity of providing care to TRD in youth with autism, suggesting that an augmentation therapy with lithium, a commonly recommended therapeutic strategy for refractory depression in typically developing samples, may also be effective in this population.
Diversity and inclusion in clinical trials: Evolution throughout the development of an mRNA COVID-19 vaccine
Authors: Hill Jameka , Montross Diane , Ivarsson Melanie
Published: April 2023

Despite the importance of equitable representation in clinical trials, disparities persist with racial and ethnic minorities remaining largely underrepresented in trial populations. During the coronavirus disease 2019 (COVID-19) pandemic, wherein disease disproportionately affected racial and ethnic minority groups, the necessity for diverse and inclusive representation in clinical trials has been further highlighted. Considering the urgent need for a safe and efficacious vaccine, COVID-19 vaccine clinical trials faced marked challenges in rapidly enrolling participants without forgoing diverse representation. In this perspective, we summarize Moderna’s approach toward achieving equitable representation in mRNA-1273 COVID-19 vaccine clinical trials, including the COVID-19 efficacy (COVE) study, a large, randomized, controlled, phase 3 trial of mRNA-1273 safety and efficacy in adults. We describe the dynamics of enrollment diversity throughout the COVE trial and the need for continuous, efficient monitoring and rapid pivoting from initial approaches to address early challenges. Insights gained from our varied and evolved initiatives provide key learnings toward achieving equitable representation in clinical trials, including establishing and listening to a Diversity and Inclusion Advisory Committee, repeatedly engaging with key stakeholders on the necessity for diverse representation, creating and disseminating inclusive materials to all trial participants, establishing methods to raise awareness for interested participants, and enhancing transparency with trial participants to build trust. This work shows that diversity and inclusion in clinical trials can be attained even in the most extreme circumstances and highlights the importance of efforts toward building trust and empowering racial and ethnic minorities with the knowledge to make informed medical treatment decisions.
Microbial and chemical stability of Acheta domesticus powder during one year storage period at room temperature
Authors: Marzoli Filippo , Tata Alessandra , Zacometti Carmela , Malabusini Serena , Jucker Costanza , Piro Roberto , Ricci Antonia , Belluco Simone
Published: April 2023

The sustainability of food systems is of growing concern worldwide, so insects are a growing source of animal proteins for food and feed. Among insect species, the house cricket, Acheta domesticus, is a promising option from a sustainability point of view. This study aimed at evaluating both microbiological and chemical stability of A. domesticus powders during one year of storage at room temperature. Our study was conducted on cricket powders obtained by three different processes: drying at 80°C (P80), drying at 120°C (P120), and lyophilization (PL). Regarding microbiological profile, the pathogens Listeria monocytogenes and Salmonella were not detected, while total viable count and lactic acid bacteria tended to decrease during the storage period. Bacillus cereus was detected at low counts during the entire storage period, but only one replicate of P80 exceeded the limit set for A. domesticus by the European Commission Implementing Regulation 2017/2470. The measured protein contents of the cricket powders immediately after production ranged between 60.6 and 64.3%. The peroxide values were far higher than the limit established by the EU Regulation in all samples. Higher amounts of hexanal and pentanal were detected in P80 and P120 than in PL, indicating that oven drying could enhance lipid oxidation. In conclusion, a one year shelf-life can suitably be ascribed to the analyzed cricket powders from a microbiological point of view, but lacked chemical stability and had a clear early tendency toward rancidity. The samples dried at 120°C and lyophilized never exceeded the limit set by European Commission for B. cereus count in A. domesticus powder. In addition, lyophilized samples showed the lowest values of hexanal and pentanal, the aldehydes that are primarily responsible for the rancid smell. The oxidative status of the final products could be strongly influenced by the powder processing, so for this reason, edible insect species-specific post-rearing protocols should be implemented. These results open an interesting scenario for a long period of storage of insect powder in the absence of a cold chain, making the insect market an increasingly sustainable sector.
Case report: Endoscopic frontal sinus opening surgery for noninflammatory frontal sinus headache: A short case series
Authors: Xie Yan , Wu Shiqi , Cui Wanling , Zeng Dandi , Chen Feifei , Liang Fangqi , Lu Rongrong , Zhang Chenyu , Jiang Luyun
Published: April 2023

Objective

The objectives of this study were to analyze rhinogenic headache, i.e., noninflammatory frontal sinus headache, a headache caused by bony obstruction of the frontal sinus drainage channels that receives relatively insufficient attention clinically, and to propose endoscopic frontal sinus opening surgery as a treatment based on the etiology.

Study Design

Case series.

Setting

From the data of patients with noninflammatory frontal sinus headache who underwent endoscopic frontal sinus surgery in Hospital of Chengdu University of Traditional Chinese Medicine during 2016–2021, data for three cases with detailed postoperative follow-up data were extracted for case series reports.

Methods

This report provides detailed information on three patients with noninflammatory frontal sinusitis headache. Treatment options include surgery and rechecking, with the visual analogue scale (VAS) scores of preoperative and postoperative symptoms, CT, and endoscopic images. Three patients had common characteristics: the clinical manifestations were recurrent or persistent with pain and discomfort in the forehead area, but there was no nasal obstruction or runny nose; the paranasal sinus CT revealed no signs of inflammation in the sinuses but suggested bony obstruction of the drainage channel of the frontal sinus.

Results

All three patients had recovery from headache, nasal mucosal recovery, and patent frontal sinus drainage. The recurrence rate of forehead tightness and discomfort or pain was 0.

Conclusion

Noninflammatory frontal sinus headache does exist. Endoscopic frontal sinus opening surgery is a feasible treatment modality that can largely or even completely eliminate the stuffy swelling and pain in the forehead. The diagnosis and surgical indications for this disease are based on a combination of anatomical abnormalities and clinical symptoms.
Improved DQN for Dynamic Obstacle Avoidance and Ship Path Planning
Authors: Yang Xiao , Han Qilong
Published: April 2023

The avoidance of collisions among ships requires addressing various factors such as perception, decision-making, and control. These factors pose many challenges for autonomous collision avoidance. Traditional collision avoidance methods have encountered significant difficulties when used in autonomous collision avoidance. They are challenged to cope with the changing environment and harsh motion constraints. In the actual navigation of ships, it is necessary to carry out decision-making and control under the constraints of ship manipulation and risk. From the implementation process perspective, it is a typical sequential anthropomorphic decision-making problem. In order to solve the sequential decision problem, this paper improves DQN by setting a priority for sample collection and adopting non-uniform sampling, and it is applied to realize the intelligent collision avoidance of ships. It also verifies the performance of the algorithm in the simulation environment.
Experimental Evaluation of Fatigue Strength of AlSi10Mg Lattice Structures Fabricated by AM
Authors: Ferro Carlo Giovanni , Varetti Sara , Maggiore Paolo
Published: April 2023

There is evidence that Additive Manufacturing (AM) plays a crucial role in the fourth industrial revolution. The design freedom provided by this technology is disrupting limits and rules from the past, enabling engineers to produce new products that are otherwise unfeasible. Recent developments in the field of Selective Laser Melting (SLM) have led to a renewed interest in lattice structures that can be produced non-stochastically in previously unfeasible dimensional scales. One of the primary applications is aerospace engineering where the need for light weights and performance is urgent to reduce the carbon footprint of civil transport around the globe. Of particular concern is fatigue strength. Being able to predict fatigue life in both LCF (Low Cycle Fatigue) and HCF (High Cycle Fatigue) is crucial for a safe and reliable design in aerospace systems and structures. In the present work, an experimental evaluation of compressive–compressive fatigue behavior has been performed to evaluate the fatigue curves of different cells, varying sizes and relative densities. A Design of Experiment (DOE) approach has been adopted in order to maximize the information extractable in a reliable form.
Decision-Making Strategies for Close-Range Air Combat Based on Reinforcement Learning with Variable-Scale Actions
Authors: Wang Lixin , Wang Jin , Liu Hailiang , Yue Ting
Published: April 2023

The current research into decision-making strategies for air combat focuses on the performance of algorithms, while the selection of actions is often ignored, and the actions are often fixed in amplitude and limited in number in order to improve the convergence efficiency, making the strategy unable to give full play to the maneuverability of the aircraft. In this paper, a decision-making strategy for close-range air combat based on reinforcement learning with variable-scale actions is proposed; the actions are the variable-scale virtual pursuit angles and speeds. Firstly, a trajectory prediction method consisting of a real-time prediction, correction, and judgment of errors is proposed. The back propagation (BP) neural network and the long and short term memory (LSTM) neural network are used as base prediction network and correction prediction network, respectively. Secondly, the past, current, and future positions of the target aircraft are used as virtual pursuit points, and they are converted into virtual pursuit angles as the track angle commands using angle guidance law. Then, the proximity policy optimization (PPO) algorithm is applied to train the agent. The simulation results show that the attacking aircraft that uses the strategy proposed in this paper has a higher win rate during air combat and the attacking aircraft’s maneuverability is fully utilized.