bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary Hypertension Remodels the Genomic Fabrics of Major Functional Pathways
Authors: Mathew Rajamma , Huang Jing , Iacobas Sanda , Iacobas Dumitru
Published: December 2019

Pulmonary hypertension (PH) is a serious disorder with high morbidity and mortality rate. We analyzed the right ventricular systolic pressure (RVSP), right ventricular hypertrophy (RVH), lung histology and transcriptomes of six weeks old male rats with PH induced by: 1) hypoxia (HO), 2) administration of monocrotaline (CM) or 3) administration of monocrotaline and exposure to hypoxia (HM). The results in PH rats were compared to those in control rats (CO). After four weeks exposure, increased RVSP and RVH, pulmonary arterial wall thickening, and alteration of the lung transcriptome were observed in all PH groups. The HM group exhibited the largest alterations and also neointimal lesions and obliteration of lumen in small arteries. We found that the PH increased the expression of caveolin1, matrix metallopeptidase 2 and numerous inflammatory and cell proliferation genes. The cell-cycle, vascular smooth muscle contraction and the oxidative phosphorylation pathways, as well as their interplay were largely perturbed. Our results also suggest that the up-regulated Rhoa (ras homolog family member A) mediates its action through expression coordination with several ATPases. The upregulation of antioxidant genes and the extensive mitochondrial damage observed especially in HM group, indicate metabolic shift towards aerobic glycolysis.
Integrated Method for Rice Cultivation Monitoring Using Sentinel-2 Data and Leaf Area Index
Authors: Ali Abdelraouf M. , Savin Igor , Poddubsky Anton , Aboelghar Mohamed , Salem Nasser
Published: December 2019

Rice is an essential crop for national food security in Egypt. Increasing the population calls for regular increases in rice production. At the same time, cultivated rice crop areas should be decreased because of the gradual scarcity of irrigation water. This means more rice production should be gained from less rice area. This situation calls for the annual accurate system for rice monitoring and yield estimation. Therefore, it is necessary to apply a remotely sensed based system for rice cultivation assessment using satellite imagery parallel with field measurements of some biophysical parameters. Multi-temporal normalized difference vegetation index (NDVI) extracted from twelve sentinel-2 imagery cover the whole summer season with variance and maximum value assessed by ground control points (GCPs), were used to isolate uncultivated areas, then to isolate rice areas and other vegetation covers. object-based classification methods with kappa co-efficient 0.9261 and overall accuracy 94.92% was generated to discriminate rice crop area and other summer crops on the study area. Leaf area index (LAI) for the experiment the l site was calculated using the surface energy balance algorithm for Land (SEBAL) model and then tested versus measured (LAI). NDVI and LAI were used to generate an empirical ran rice yield prediction model. Then, this model was used to produce rice to yield a map. The study was carried out in an experimental site in Kafr Elsheikh governorate with a total area of 5040 Hectare. Produced cultivated land use map showed 95% overall accuracy. High similarity was observed between measured and calculated (LAI) with high accuracy of R2 = 0.94. of Rice, yield map showed expected to yield more to than a month before harvest. The generated yield map was tested using a correlation coefficient between actual yield and estimated yield with high accuracy R2 = 0.9. This method is applicable to estimate the acreage and productivity of rice in the northern Nile delta in adequate time before harvest.
A Comparative Study on Cooling Period Thermal Comfort Assessment in Modern Open Office Landscape in Estonia
Authors: Kiil Martin , Simson Raimo , Thalfeldt Martin , Kurnitski Jarek
Published: December 2019

Local thermal comfort (TC) and draught rate (DR) has been studied widely. There has been more meaningful research performed in controlled boundary condition situations than in actual work environments involving occupants. TC conditions in office buildings in Estonia have been barely investigated in the past. In this paper, the results of TC and DR assessment in five office buildings in Tallinn are presented and discussed. Studied office landscapes vary in heating, ventilation and cooling (HVAC) system parameters, room units and elements. All sample buildings were less than six years old, equipped with dedicated outdoor air ventilation system and room conditioning units. The on-site measurements consisted of TC and DR assessment with indoor climate questionnaire (ICQ). The purpose of the survey is to assess the correspondence between HVAC design and the actual situation. Results show, whether and in what extent the standard-based criteria for TC is suitable for actual usage of the occupants. Preferring one room conditioning unit type or system may not guarantee better thermal environment without draught. Although some HVAC systems observed in this study should create the prerequisites for ensuring more comfort, results show that this is not the case for all buildings in this study.
A Self-Reflection Program for Smoking Cessation in Adolescents: A Phenomenological Study
Authors: Sim In Ok , Hwang Eun Jeong , Sin Bo Ra
Published: December 2019

The study aimed to understand the experiences of adolescent smokers who participated in a smoking cessation program based on self-reflection, and to develop the theoretical basis for constructing similar programs. The participants, ten students from middle and high schools located in cities G and S, were interviewed after the program ended. Data were collected from August to November 2019 and analyzed using a phenomenological approach to understand participant experiences in depth. The analysis revealed five major themes: ‘Uniqueness of the Program,’ ‘Perception of Smoking Cessation,’ ‘Positive Reflection on Life,’ ‘Understanding Others,’ and ‘A Search for Hope and Vision in Life.’ The findings revealed that the smoking cessation program facilitated the development of self-identity and vision, which may indirectly strengthen the motivation for adolescent smokers to quit smoking. These findings suggest the need for a life-changing smoking cessation program that enhances self-concept and self-esteem. Moreover, it highlights the importance of follow-up research to ensure effectiveness, and the need to develop programs with creative content.
Compound Lactobacillus sp. Administration Ameliorates Stress and Body Growth Through Gut Microbiota Optimization on Piglet Model
Authors: Yang Jiajun , Wang Chonglong , Huang Kehe , Zhang Minhong , Wang Jing , Pan Xiaocheng
Published: December 2019

The composition of bacteria in the gastrointestinal tract of piglets is easily affected by environmental changes, particularly during the weaning period. Compound strains of Lactobacillus reuteri and Lactobacillus salivarius were supplemented to piglets during pre- and post-weaning to determine their effects in improving the growth performance and ameliorating the diarrhea rate and stress caused by antioxidation in piglets. A larger number of L. reuteri and L. salivarius colonized the distal segment of the ileum and the total numbers of Lactobacillus spp. and Bifidobacterium were higher in the ileal mucous membrane and cecal lumen with probiotics supplementation. The numbers of antioxidative and immune molecules were increased in the plasma following compound bacteria (CL) supplementation, whereas cortisol and endotoxin levels were lower and growth hormone and insulin-like growth factor 1 were higher. Spearman’s and KEGG analysis of the bacterial operational taxonomic unit and antioxidative and immune indices and metabolic genes indicated that the body growth modulation by CL supplementation could be attributed to optimization of the intestinal bacterial composition. Collectively, these results suggest that supplementation with CL could reduce stress and improve the growth performance of piglets during weaning by optimizing the intestinal bacterial composition.
Development of a Decision-Making Framework for Distributed Energy Systems in a German District
Authors: Schmeling Lucas , Schönfeldt Patrik , Klement Peter , Wehkamp Steffen , Hanke Benedikt , Agert Carsten
Published: December 2019

The planning and decision-making for a distributed energy supply concept in complex actor structures like in districts calls for the approach to be highly structured. An strategy with strong use of energetic simulations is developed here and the core elements shall be presented. The exemplary implementation is shown using the case study of a new district on the former Oldenburg airbase in northwestern Germany. The process is divided into four consecutive phases, which are carried out with different stakeholder participation and use of different simulation-tools. Based on a common objective, a superstructure of the applicable technologies is developed. Detailed planning is then carried out with the help of an optimal sizing algorithm and Monte Carlo based risk assessment. The process ends with the operating phase, which is to guarantee a further optimal and dynamic mode of operation. The main objective of this publication is to give a brought introduction to the intended planning processes and decision-making framework and to find and identify research gaps that will have to be addressed in the future.
A Cultural Perspective on the English Translation of Nezha
Authors: Li Xiaoyan
Published: December 2019

Achieving a tremendous box office success in China, Na Zha is a mythical movie with Chinese characteristics, showing the social culture of China, analyzing the current ideological situation of the modern Chinese people, but it flopped in the American market. This paper analyses the gains and losses in the translation of the film Nezha from the perspective of culture.
Comparison of personal pronouns in Indonesian and Uzbek languages
Authors: Sarieva Zamira
Published: December 2019

The role of pronouns is to replace  nouns or noun phrases in the sentences. Personal pronouns replace proper and common nouns, so we do not have to repeat them. This  article compares personal pronouns in Indonesian and Uzbek languages. The most important point in the analysis is cultural aspect and its influence on the usage of personal pronouns. The article will reveal the influence of such cultural aspects like politeness and kinship based on example of personal pronoun "you" in Indonesian and Uzbek languages. Influence of formal and informal speech on denoting personal pronouns in Indonesian and Uzbek languages. The analysis will occur on the basis of examples that were taken from the sources which are given in the references.
Early versus delayed postoperative oral hydration in children following general anesthesia: a prospective randomized trial
Authors: Yin Xiaorong , Zeng Xiaoqi , Wang Ting , Dong Bibbin , Wu Menghang , Jia Anna , Ye Ling
Published: December 2019

Background: oral hydration has typically not been administered for between 4 and 6 hours postoperative for children’s safety. But children are more likely to suffer from apnea, crying and agitation, wound bleeding, and other complications during the post-anesthesia recovery period because of thirsty and fear. This Prospective, randomized study sought to assess the compare the early and late oral hydration (EOH and DOH, respectively) in children following general anesthesia, with the goal of assessing relative safety and tolerability and thereby improving patient comfort. Methods : A total of 2,000 children corresponding to the American Society of Anesthesiology (ASA) I-III were randomized into an EOH group (n=1000) and a DOH group (n=1000). For the former group, children were administered a small amount of drinking water following recovery of the swallowing reflex, and children's vital signs were monitored for 20 minutes in a postanesthesia care unit (PACU). DOH group patients received water at 4 h following general anesthesia). All patients underwent monitoring to assess their thirst, satisfaction, oropharyngeal discomfort, nausea, and vomiting. Results: Complete data were collected from a total of 1770 patients (EOH=832, DOH=938) and was compared via chi-squared and t-tests as appropriate. There was no hypoxemia in either group, nor did the incidence of nausea and vomiting differ between the two groups (P>0.05). The thirst score of the EOH group was significantly decreased relative to the DOH group in the children over 5 years old after drinking for 10 to 20 minutes (P<0.05). Conclusions: For children undergoing general anesthesia, a small amount of drinking water in the early stages of recovery will not increase the incidence of nausea, vomiting, or hypoxemia, but will decrease thirst and improve satisfaction. It is important, however, that medical staff carefully monitor the swallowing reflex and vital signs of all children.
Contraceptive use and associated factors among sexually active HIV positive women attending ART clinic in FHRH in Bahir Dar, north west, Ethiopia, 2018. Facility based cross-sectional study.
Authors: ayalew tilksew , Tewabe Tilahun , Abdanur Abdulhakim , Jenbere Demoze , Ayehu Mastewal , Talema Girma
Published: December 2019

Abstract
Back ground: Contraception helps prevent unplanned pregnancies and mother to child HIV transmission among human immune virus positive women. Contraceptive use status and associated factors were not well addressed in the study area. This study aimed to assess contraceptives use and associated factors among HIV positive sexually active women at anti-retroviral therapy clinic in Felege Hiwot Referral Hospital, Northwest Ethiopia.
Method : A facility based quantitative cross-sectional study was conducted from June 01 -30, 2018, among 308 randomly selected sexually active HIV positive women of reproductive age in Felege Hiwot Referral Hospital anti-retro viral treatment clinic. A pre-tested interviewer-administered questionnaire was used to collect data. Data were analyzed using SPSS version20. Descriptive statistics were used to summarize socio-demographic characteristics of participants. A multivariate logistic regression analysis method was employed and odds ratio with 95% confidence interval was used to control possible confounders. Statistical significance was declared at p-value <0.05.
Results: The current study revealed that overall contraception use among sexually active HIV positive women was 38.3 %( 95%CI: 32.5%-43.5%). Women with age range of 15-34 years old (AOR =3.089, 95%CI: 1.591-5.999), HIV status disclosure to sex partner, (AOR=2.75995%CI: 1.142-6.663), previous contraception utilization experience; (AOR=3.361, 95%CI: 1.677-6.736), Sexual activity in the last six months (AOR5.451, 95%CI: 2.724-10.908) and had drinking habit (AOR=4.351, 95%CI: 1.824-10.379) were the main predictors of contraceptive use.
Conclusion: Contraceptive use was low in the current study area. Efforts should be strengthened to increase contraception use among human immune virus positive women. Anti-retro viral treatment and family planning services should be integrated to increase contraceptive use uptake in the study area.
Keywords: Contraceptive use, Contraception, Human immune virus positive women, Bahir Dar, North west Ethiopia.
Water, sanitation and hygiene (WASH) Promotion: A qualitative analysis of experiences of stakeholders in rural KwaZulu-Natal
Authors: Mulopo Chanelle , Chimbari Moses J
Published: December 2019

The authors have requested that this preprint be removed from Research Square.
Dynamic interactions among the industrial sector and its determinants in Jordan
Authors: Abuoliem Nawaf , Mohd Nor Safwan , Safiih Lola Muhamad , Matar Ali
Published: December 2019

The industrial sector is one of the most vital sectors in the national economy, so different local and global factors affect its performance. The study examines the impact of the global and local macroeconomic variables on the industrial index of the Amman Stock Exchange. This study covered the period from January 2007 to December 2016, which is considered as a crucial period in the Middle Eastern countries. This period encompasses the worldwide economic meltdown from 2007 to 2008, the Arab spring of 2010 and the wars in Syria and Iraq from 2012 to 2014. The macroeconomic variables used in this study as domestic variables from Jordan were the deposit interest rate (IN), inflation rate (INF), money supply 2 (MS2), trade balance (TR), producer price index (PPI) and the industrial production index (IPI). At the same time the global oil price (WTI) was used as a global factor to measure the external shocks. This study used the ARDL bound testing approach to examine the co-integration, short-run and long-run relationships. Moreover, Granger causality test was used to detect the causality relationship in the short and long run between the selected macroeconomic indicators and the industrial index. It was found out that the inflation rate positively influenced the industrial index, which provides some evidence that the industrial sector in Jordan acts as a hedge against inflation. In addition, the global oil price showed a significant negative impact on the industrial sector. Some important implications for investors, government bodies, and policymakers are discussed.
Employees’ perceptions and the relationship between human resource management and organizational performance: a conceptual view
Authors: Pombo Gonçalo , Gomes Jorge
Published: December 2019

The paper presents a review of the literature and advances a set of propositions concerning the employees’ perceptions on the relationship between human resource management and organizational performance. The study is aimed at filling the gap in the literature on the employees’ perception regarding human resource policies and the relationship to organizational performance. Social information processing theory is used to advance the insights on how employees’ performance about human resource policies may influence the organizational performance. The review indicated that there is a positive relationship between the employees’ perceptions of human resource policies and overall performance of a given organization. A positive perception of the implemented policies influences various individual outcomes such as commitment, engagement, and satisfaction, amongst others. Shared perceptions among the employees are also considered to have a considerable impact on the organizational performance. Nevertheless, there is a need for further research to explore the relationship between human resource management and organizational performance in more detail.
A Estratégia Como Prática em Diferentes Ritmos: um Estudo do Strategizing em Bandas Musicais
Authors: Ramos Marlos Vinícius Oliveira , Borges Jacquelaine Florindo
Published: December 2019

Este artigo propõe um diálogo entre a estratégia como prática social e os estudos culturais, especificamente a articulação entre estilos e identidades, a partir da questão: como práticas de estilo moldam o strategizing de bandas musicais? Para tanto, foi realizada uma pesquisa de campo com 11 bandas musicais, orientada pelo método de múltiplos casos e por uma abordagem qualitativa. Os dados foram coletados com a aplicação da técnica de entrevistas com músicos e empresários, da pesquisa documental em websites e da análise de foto/imagem das bandas. Os resultados mostram que as bandas desenvolvem quatro práticas estratégicas centrais: (a) identidade sonora; (b) identidade estética; (c) coletivo de identidades e habilidades dos músicos (formação e composição da banda); e (d) identidade econômica (crescimento e popularização da banda).  Essas práticas são conduzidas a partir de rotinas interativas, comportamentais/comunicacionais, procedimentos de aprendizagem e uso de instrumentos de gestão. É no fluxo dessas práticas que se constitui a estratégia artística da banda: um complexo de ações e instrumentos visando reconhecimento artístico e resultados comerciais no contexto cultural da época. A pesquisa mostra que a abordagem cultural do strategizing é um caminho promissor para conectar diferentes níveis de análise e temas de pesquisa ainda pouco presentes nos estudos da estratégia como prática social: práticas culturais de estilo e interações entre identidades individuais e coletivas em organizações e manifestações culturais.
Az induktív gondolkodás fejlődésének összehasonlító vizsgálata
Authors: Csapó Benő , Hotulainen Risto , Pásztor Attila , Molnár Gyöngyvér
Published: December 2019

A tanulmány az induktív gondolkodás finn és magyar tanulók körében elvégzett összehasonlító vizsgálatának eredményeit mutatja be. Arra keresi a választ, hogy a Magyarországon kidolgozott mérőeszközök azonos módon működnek-e Finnországban, egy másik pedagógiai kultúrájú oktatási rendszerben, és a különböző életkorú diákok körében, hogyan fejlődik a diákok gondolkodása, továbbá milyen különbségek vannak a fiúk és a lányok között a két iskolarendszerben. A felmérés résztvevői Vantaa város és az SZTE Oktatáselméleti Kutatócsoport partneriskoláinak negyedik és hetedik évfolyamos diákjai közül kerültek ki. Bár egyik minta sem tekinthető reprezentatívnak, így a teljesítményeket nem lehet közvetlenül összehasonlítani, a felvett adatok alkalmasak a kutatási kérdések megválaszolására. A mérés eszköze egy több korábbi vizsgálatban már alkalmazott induktív gondolkodás teszt volt (figurális és numerikus analógiák és sorozatok), amelynek kiközvetítésére az eDia online tesztplatformon keresztül került sor. A finn diákok tableten, a magyarok asztali számítógépen (egér, billentyű) oldották meg a feladatokat. Az eredmények azt mutatják, hogy a tesztek reliabilitása a finnre való átültetés során nem változott lényegesen. A skála-invariancia elemzések szerint a teszt másik környezetben való felhasználása során megfelelt a konfigurális és a részleges metrikus invariancia feltételeinek, azonban a metrikus invarianciának már nem. Váratlan eredmény, hogy a magyar diákok mindkét életkorban jobban teljesítettek, mint a finnek, különösen a numerikus feladatokban. Mivel e felmérés mintái nem voltak reprezentatívak, a megfigyelt különbség megerősítése és okainak felderítése további vizsgálatokat igényel.
Comportamento empreendedor feminino: estudo no Estado do Rio Grande do Sul
Authors: Matte Juliana , Voltz Thales de Oliveira , Schneider Ana Cristina Sant`Anna , Miri Daniel Hank , Chais Cassiane , Ganzer Paula Patrícia , Radaelli Adrieli Alves Pereira , Olea Pelayo Munhoz
Published: December 2019

As mulheres empreendedoras representam quase metade dos novos negócios brasileiros abertos em 2017. Portanto, este artigo busca analisar as características do comportamento empreendedor feminino com o estudo nos munícipios do estado do Rio Grande do Sul. Para isso, pesquisou-se o comportamento empreendedor de empresárias a partir dos estudos do psicólogo David McClelland sobre o empreendedorismo comportamental, abordando também aspectos sociodemográficos das participantes e suas motivações para empreender ou continuar o empreendimento. O estudo possui uma abordagem quantitativa, com aplicação de questionário ?Diagnóstico Comportamental?, do Projeto Negócio a Negócio do SEBRAE, a 711 empresárias gaúchas. Como resultados, constatou-se que as principais características das empreendedoras estão contidas no conjunto da realização: vontade de atingir objetivos desafiadores, busca por fazer algo sempre melhor e de maneira mais eficiente e busca pela excelência e pelo sucesso, a fim de obter o reconhecimento por seus feitos. A partir dessas características, torna-se possível a elaboração de novos indicadores de políticas públicas de incentivo ao empreendedorismo feminino no estado gaúcho.
Development of a full-cycle water remediation process
Authors: Yerushalmi L. , Seyhi B.
Published: December 2019

A full-cycle water remediation process has been developed by expanding the capacity of an existing water treatment technology that uses combined ozonation and ultrafiltration membrane processes. The developed water reclamation process treated the effluent of a full-scale wastewater treatment plant in Canada that uses biological treatment processes to treat municipal wastewater, and reduced the colour, turbidity, suspended solids, iron and pathogen content of the effluent. The removal of hardness from the wastewater effluent was accomplished by the precipitation process. The use of lime (0.2 g/L) in the presence of NaOH operating at pH 11 showed the best results, reducing the water hardness by 89.1%. The advanced treatment capability of ozonation (8–10% w/w) and polyvinylidene fluoride (PVDF) hollow fiber ultrafiltration (UF) membrane produced a reliable source of water for municipal, industrial and agricultural use. The developed process offers important environmental benefits by reducing the diversion of water from sensitive ecosystems, decreasing wastewater discharge and preventing pollution.
Photoelectrocatalytic decolorization of methylene blue using reduced graphene oxide modified TiO2 on filter paper
Authors: Li Xiaoqiang , Zhang Jialin , Pang Zengyuan , Zhu Yanan , Chen Xin , Sun Qian , Li Yonggui
Published: December 2019

In this work, titanium dioxide (TiO2) was modified with reduced graphene oxide (rGO), and then coated on filter paper to prepare the rGT/FP photoelectrode for the photoelectrocatalytic (PEC) decolorization of methylene blue (MB). The physicochemical properties of the rGT/FP photoelectrode were characterized using scanning electron microscopy (SEM), X-ray diffraction (XRD) analysis and UV-Vis diffuse reflectance spectroscopy (DRS). The decolorization results demonstrated that the photocatalytic (PC) and electrocatalytic (EC) efficiency of the photoelectrode could be significantly improved by the modification of rGO. The improvement of PC and EC efficiency might attribute to the existence of rGO, which could extend the light-harvesting efficiency, promote the photocurrent response value and suppress the charge recombination. Furthermore, the PEC decolorization of MB using the rGT/FP photoelectrode presented higher efficiency than the sum of PC and EC decolorization, indicating the synergistic effect between the photo and electrical energy.
Single-cell Analysis of β2-Adrenergic Receptor Dynamics by Quantitative Fluorescence Microscopy
Authors: Haji Esraa , Mahri Saeed Al , Aloraij Yumna , Malik Shuja , Mohammad Sameer
Published: December 2019

Background:

G protein-coupled receptors (GPCRs) represent the largest family of surface proteins and are involved in the regulation of key physiological processes. GPCRs are characterized by seven transmembrane domains, an extracellular N-terminus and an intracellular C-terminus. Cellular response of these receptors to their ligands is largely determined by their surface expression and postactivation behavior including expression, desensitization and resensitization.

Objective:

To develop a quantitative fluorescence Microscopy assay to study β2- Adrenergic receptor expression and desensitization.

Method:

β2-Adrenergic receptor cDNA was engineered to put an HA tag at the extracellular N-terminus and GFP Tag at the intracellular C-terminus. GFP fluorescence serves as a measure of total cellular expression; whereas staining with CY3 conjugated anti-HA antibodies without permeabilizing the cells represents the surface expression of β2-AR. The images are quantified and amount of CY3 (surface) and GFP (total) fluorescence for each cell determined using image processing software.

Results:

The method is sensitive and allows for the simultaneous measurement of surface and total expression of β2-AR.

Conclusion:

A highly accurate method is described for measuring β2-AR surface and total expression based on single-cell quantitative immunofluorescence. The method can be used to determine agonist-induced desensitization and resensitization process as well as receptor kinetics like endocytosis and exocytosis of β2-Adrenergic receptor and can be applied to essentially any other GPCR.
DBU Catalysis: An Efficient Synthetic Strategy for 5,7-disubstituted-1,2,4- triazolo[1,5-a]pyrimidines
Authors: Pandey Yogesh K. , Mishra Anu , Rai Pratibha , Singh Jaya , Singh Jagdamba , Singh Ramendra K.
Published: December 2019

Aim and Objective:

An efficient and facile DBU catalysed synthesis of highly significant motif
5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines under solvent-free condition has been reported.

Materials and Methods:

To a round bottom flask, 1.0 mmol of chalcone (1), 1.5 mmol of 3-amino-1,2,4-
triazole (2) and 30 mol% of DBU were added at 70 °C and stirred in solvent-free condition. After the
completion of the reaction (monitored by TLC), water (10 ml) was added. The aqueous layer was extracted
with ethyl acetate (3 ×10 ml). The combined organic layers were dried over anhydrous Na2SO4. The combined
organic layers were evaporated under reduced pressure and the resulting crude product was purified by column
chromatography by using ethyl acetate and hexane as eluent.

Results:

Reaction using chalcone and 3-amino-1,2,4-triazole as model substrates were carried out under
different reaction conditions and it was observed that 30 mol% of DBU under the solvent-free condition at
70 °C was the optimum temperature for the proposed synthesis.

Conclusion:

Use of DBU (an organocatalyst) as a base, operational simplicity, high yield of products and short
reaction time are some of the significant advantages associated with the proposed strategy.
A Mini Review on Recent Advancements in the Therapeutic Potentials of Benzothiazoles
Authors: Bhutani Rubina , Kapoor Garima , Pathak Dharam P. , Husain Asif , Kant Ravi , Ali Ruhi
Published: December 2019

Among the various fused heterocyclic rings, benzothiazole and its analogs have been explored
broadly in search of newer therapeutic medicinal agents. The benzothiazole scaffold has been
associated with huge biological potential like anticancer, antidiabetic, anti-inflammatory, antitubercular,
antiviral, anti-convulsant etc. The occurrence of benzothiazole core in various compounds
proves its value in the sphere of pharmaceutical chemistry. The connected research and developments in
benzothiazole based chemistry become an active topic for medicinal scientists. A large number of benzothiazole
and its heterocyclic derivatives are available in the market and used for the treatment as clinical
drugs have been extensively used in practice to treat diverse types of ailments with high therapeutic
potential. This review presents the latest therapeutic developments of benzothiazole containing compounds
in the medicinal chemistry.
Radio-thermo-sensitivity Induced by Gold Magnetic Nanoparticles in the Monolayer Culture of Human Prostate Carcinoma Cell Line DU145
Authors: Rajaee Zhila , Khoei Samideh , Mahdavian Alireza , Shirvalilou Sakine , Mahdavi Seied R. , Ebrahimi Marzieh
Published: December 2019

Background and Objective:

Prostate cancer is the second cause of death in men worldwide. In this
study, the cytotoxic effects of PLGA polymer-coated gold Magnetic Nanoparticles (MGNPs), as a novel treatment
to enhance radiation and thermal sensitivity in the presence of hyperthermia (43°C) and electron beam, on
DU145 prostate cancer cells were investigated.

Methods:

Nanoparticles were characterized using TEM, DLS, XRD and SAED methods. MGNPs entrance into
the cells was determined using Prussian blue staining and TEM. Furthermore, the cytotoxic effects of combinatorial
treatment modalities were assessed by applying colony and sphere formation assay.

Results:

Our results revealed that the decrease of colony and sphere numbers after combinatorial treatment of
hyperthermia and radiation in the presence of nanoparticles was significantly higher than the other treatment
groups (P<0.05). This treatment method proved that it has the capability of eliminating most of the DU145 cells
(80-100%), and increased the value of the linear parameter (α) to 4.86 times.

Conclusion:

According to the study, magnetic gold nanoparticles, in addition to having a high atomic number,
can effectively transmit heat produced inside them to the adjacent regions under hyperthermia, which increases
the effects of radio-thermosensitivity, respectively.
Comparative Analysis of Simulation Applications Used for Energy Consumption in Green Buildings
Authors: Al Ka’bi Amin H.
Published: December 2019

Green Building philosophy is based on providing comfortable living environment for the residents, and simultaneously maintaining low level of negative impacts on the environment, besides applying resource efficient methodologies throughout the life cycle of the building, including efficient usage of energy resources. To achieve these goals, software applications can be used as part of Building Information Modeling (BIM), to analyze and simulate energy consumption in Green Buildings.
The main contribution of this paper lies in conducting thorough investigation and comparison of the performance of most common simulation applications used for energy consumption in green buildings, and hence the best application is selected based on unified criteria, which includes various sets of design conditions and parameters.
A Mini-review on HER2 Positive Breast Cancer and its Metastasis: Resistance and Treatment Strategies
Authors: Kumar Manish , Rajnikanth P.S.
Published: December 2019

HER2 positive breast cancer is an aggressive breast cancer followed by brain
metastasis, which emerges at the later stage of breast cancer or after a few years of treatment.
HER2+ breast cancer brain metastasis is a complex fatal disease with short survival
and resistance to first-line drugs such as Trastuzumab, lapatinib, etc. The resistance can
be due to the upregulation/downregulation of various proteins of downstream pathways
mainly PI3K/AKT pathway and MAPK pathway. In addition, the Blood-brain Barrier
(BBB) and Blood Tumor Barrier (BTB) also hinder the delivery to brain metastases. Thus
controlling the altered proteins of the downstream pathway can be a targeted approach to
control breast cancer and its brain metastasis. At the same time, targeted delivery to metastatic
sites can give a synergistic effect in controlling brain metastasis and increasing the
survival period. Various type of targeted nanocarriers such as single, dual, or multitargeted,
pH specific, or stimuli sensitive nanocarriers can be employed for providing
specific delivery to HER2+ cancer cells. Furthermore, combinations such as Trastuzumab
with tyrosine kinase inhibitors (lapatinib, neratinib, afatinib), chemotherapeutic drugs
(paclitaxel, doxorubicin, capecitabine), or some natural compounds (curcumin, Lycorine,
berberine) with anti-apoptotic activity can provide an additional effect in the management
of HER2 positive breast cancer and its metastasis.
Kajian Penggunaan Media Pembelajaran dalam Pelatihan Peningkatan Kompetensi Profesional Guru
Authors: Mashoedah Mashoedah
Published: December 2019

Tujuan dari makalah ini adalah mengkaji penggunaan media pembelajaran untuk pelatihan guru. Jenis Media pembelajaran yang bagaimana yang dapat digunakan dalam pelatihan guru untuk meningkatkan kompetensi profesional guru. Metode yang digunakan adalah studi pustaka dan online survei kepada guru yang berada di grup guru di jejaring sosial media. Penggunaan metode survei online di grup guru di jejaring sosial media diharapkan dapat menggali respon guru terhadap penggunaan media pembelajaran yang sesuai untuk pelatihan, serta permasalahan-permasalahan lain dalam peningkatan kompetensi profesional guru. Hasil kajian dan survei yang telah dilakukan menunjukkan bahwa permasalahan yang sering dihadapi oleh guru adalah ”Peningkatan kemampuan di bidang keahlian” (42%), ”Minimnya alat bantu mengajar disekolah” (24%), ”Kurikulum” (15%) dan permasalahan lainnya (19%). Sedangkan pendapat guru tentang penggunaan media pembelajaran pada pelatihan guru masih sangat diperlukan dan media pembelajaran yang diharapkan dalam pelatihan guru adalah dalam bentuk : gabungan media (49%) , video pembelajaran (29%), e-learning (15%); dan trainer kit (6%). Alternatif model pelatihan yang diharapkan adalah pengintegrasian media pembelajaran pada pelatihan peningkatan kompetensi guru.
ATAP OTOMATIS SENSOR SUHU, AIR DAN TENAGA SURYA (ALAS TSUSU)
Authors: Hendriawan Koko
Published: December 2019

Atap otomatis sensor suhu,sensor air dan surya(ALAS TSUSU) sebagai inovasi desain atap yang dapat membuka dan menutup secara otomatis.Atap adalah salah satu komponen yang sangat penting dalam sebuah bangunan. Dengan adanya dua musim yang di miliki Negara Indonesia Antara musim hujan dan kemarau atap tidak hanya sebagai fungsi utama dalam melidungi kita dari matahari dan hujan akan tetapi juga memiliki nilai estetika yang sangat tinggi misalnya intensitas cahaya yang diterima bumi kurang terang dengan rain probability (kemungkinan turun hujan) tinggi. Sedangkan pada musim kemarau, sinar matahari lebih terang dengan kemungkinan turun hujan sangat rendah, bahkan hampir tidak pernah turun hujan. Sehingga rancangan dari sebuah atap di haruskan mendapatkan perhatian yang serius. Metode pelaksanaan dalam pembuatan Atap otomatis sensor suhu,sensor air dan surya(ALAS TSUSU) adalah membuat sebuah prototype atap yang inovatif dan mensetting sensor air dan suhu sehingga atap tersebut akan bergerak secara otomatis bila terjadi perbedaan suhu dan terkena air.Prototype ini dikatakan berhasil jika mampu atap yang dibuat dapat bergerak dengan bantuan sensor dan tenaga listrik yang bersumber dari panel surya.
Analisis Desain Website Terhadap Budaya Pendekatan Teori Hofstede
Authors: Husna Amelia Fauziah
Published: December 2019

Penelitian ini bertujuan untuk mengetahui pengaruh kebudayaan terhadap desai suatu website dan mengetahui budaya apakah yang berkembang di daerah tersebut melalui desai websitenya. Metode yang digunakan adalah studi kasus. Variabel yang digunakan ada 5, sesuai dengan Teori Hofstede, yaitu Power Distance (Jarak Kekuasaan), Indivialism vs Collectivism (Individualisme vs Kolektivisme), Masculinity vs Femininity (Maskulinitas vs Feminitas), Uncertainty Avoidance (Penghindaran terhadap Ketidakpastian), dan Long Term Orientation vs Short Term Normative (Orientasi Jangka Panjang vs Orientasi Normatif Jangka Pendek. Penelitian ini membandingkan tiga website yang berasal dari tiga negara yang berbeda, bahkan benua yang berbeda. Hasilnya terdapat perbedaan desain website yang dipengaruhi oleh budayanya.
Peningkatan Kemampuan Kerjasama dalam Tim Melalui Pembelajaran Berbasis Lesson Study
Authors: Wulandari Bekti , Arifin Fatchul , Irmawati Dessy
Published: December 2019

Penelitian ini bertujuan untuk meningkatkan kualitas pembelajaran pada mata kuliah Praktik Pengolahan Sinyal Digital dan menumbuhkan aspek kerjasama yang baik dalam satu tim pada mata kuliah Praktik Pengolahan Sinyal Digital. Peningkatan kualitas pembelajaran ini menerapkan metode pembelajaran problem based learning. Dalam penelitian ini menerapkan metod lesson study model Lewis (2002) dan pelaksanaanya dilakukan dalam 3 kegiatan, yaitu: 1) Perencanaan (plan); 2) Pelaksanaan dan  Observasi (do); 3) Refleksi (see). Subjek penelitian adalah mahasiswa S1 Prodi Pendidikan Teknik Elektronika dan data diperoleh dengan cara observasi dan perekaman. Hasil penelitian menunjukkan bahwa terjadi peningkatan kualitas proses pembelajaran. Dilihat dari jumlah mahasiswa  yang  aktif  semakin  banyak, perkuliahan  tidak  membosankan karena sebagian besar mahasiswa kelihatan antusias dalam belajar. Bagi dosen juga ada keuntungannya yaitu dapat melakukan kolaborasi dengan teman sejawat dalam upaya untuk memperbaiki pembelajaran. Melalui pembelajaran lesson study ini selain dapat meningkatkan kualitas pembelajaran  sekaligus  juga  dapat  menumbuhkan aspek kerjasama yang baik dalam satu tim pada mata kuliah Praktik Pengolahan Sinyal Digital. Hal ini terlihat dari tanggung jawab dalam pengambilan keputusan, tidak memisahkan diri dari orang lain, interaksi terhadap sumber belajar, interaksi antar mahasiswa, aktifitas menyelesaikan masalah dan mahasiswa tidak pasif.
ANALISIS PENERAPAN SISTEM INFORMASI AKADEMIK (SIAKAD) 2013 MENGGUNAKAN MODEL END-USER COMPUTING SATISFACTION (EUCS) DI PROGRAM STUDI PENDIDIKAN TEKNIK INFORMATIKA
Authors: Jati Handaru
Published: December 2019

Penelitian ini bertujuan untuk mengetahui: (1) pengaruh content terhadap user satisfaction; (2) pengaruh accuracy terhadap user satisfaction; (3) pengaruh format terhadap user satisfaction; (4) pengaruh ease of use terhadap user satisfaction; (5) pengaruh timeliness terhadap user satisfaction. Penelitian ini merupakan penelitian ex-post facto, yang dilaksanakan di Program Studi Pendidikan Teknik Informatika. Teknik pengambilan sampel dengan  purposive sampling. Sampel yang diambil merupakan mahasiswa angkatan 2013 dan 2014 yang sudah menggunakan SIAKAD 2013 . Data diperoleh dengan kuesioner tertutup yang telah memenuhi persyaratan validitas  dan reliabilitas. Teknik analisis data yang digunakan adalah Partial Least Square (PLS). Hasil penelitian menunjukkan bahwa: (1) content berpengaruh terhadap user satisfaction; (2) accuracy berpengaruh terhadap user satisfaction; (3) format berpengaruh terhadap user satisfaction; (4) ease of use berpengaruh terhadap user satisfaction; (5) timeliness berpengaruh terhadap user satisfaction.
Analisis Competitive Forces and Competitive Strategy pada Sistem Informasi “Zalora.co.id”
Authors: Ekarini Fitria
Published: December 2019

Analisis Sistem Informasi Zalora.co.id ini bertujuan untuk mengetahui seberapa kuatnya strategi persaingan yang disiapkan oleh Zalora.co.id untuk menghadapi kuatnya persaingan bisnis dengan perusahaan yang bergerak di bidang yang sama. Sehingga dapat dilihat kelebihan dan kekurangan dari Sistem Informasi ini. Analisis Sistem Informasi ini menggunakan model analisis competitive forces and Competitive Strategy. Dan untuk mengatasi lima kekuatan kompetitif tersebut, perusahaan dapat menerapkan competitive strategies. Pada Zalora yang merupakan situs web belanja kebutuhan fashion yang menawarkan produk-produk dari berbagai brand termuka, baik lokal maupun internasional ini dapat dikatakan sebagai online shop yang siap untuk bersaing dengan para kompetitor di bidang yang sama. Kelemahan dari Sistem Informasi Zalora ini terdapat pada lemahnya Zalora dalam mengahadapi kekuatan Ancaman Kekuatan tawar pelanggan, Ancaman produk pengganti yang mungkin menangkap mangsa pasar, Ancaman industri pendatang baru. dan kelebihan dari Sistem Infomasi Zalora terletak pada kuatnya Zalora dalam menghadapi kekuatan Ancaman Persaingan dari pesaing dalam industri dan Ancaman Kekuatan tawar pemasok . dan juga kelebihan dari Sistem Informasi Zalora terletak pada Strategi Cost Leadership, Strategi Inovasi, dan Strategi Aliansi yang sudah ada dalam Sistem Infomasi ini.Kata Kunci: Sistem Informasi, Competitive Forces, Competitive Strategy
PENGOLAHAN CITRA UNTUK IDENTIFIKASI TELUR BERDASARKAN UKURAN
Authors: Sidiq Syahrul Awalludin
Published: December 2019

Salah satu Home Industri penyortir telur di Yogyakarta, adalah Tempel Ambarukmo. Penyortiran awalnya dilakukan secara manual tetapi membutuhkan waktu yang lama. Pengunaan mesin grading untuk mengatasi masalah tersebut, namun harga relatif mahal. Oleh karena itu, perlu adanya sistem otomatis untuk penyortiran telur sehingga menghemat waktu, tenaga, dan biaya. Penelitian ini bertujuan untuk mengembangkan suatu sistem yang mampu mendeteksi dan memisah telur berdasarkan ukuran menggunakan citra digital dengan media interface GUI (Graphical User Interface) yang memanfaatkan software matlab. Telur dikategorikan menjadi 5 kategori (Sangat Kecil, Kecil, Sedang, Besar, Sangat Besar). Dalam proyek akhir ini dirancang dengan menggunakan metode waterfall. Pengolahan citra terdiri dari beberapa proses. Proses yang pertama adalah operasi pengubahan warna ke grayscale. Proses yang kedua adalah operasi pengubahan warna grayscale menjadi biner menggunakan metode threshold. Proses yang ketiga  adalah proses morfologi filling holes penghilangan noise dari hasil citra threshold. Selanjutnya akan ditampilkan hasil di GUI matlab berupa keputusan. Apakah telur tersebut termasuk dalam klasifikasi sangat besar, besar, sedang, kecil, atau sangat kecil. Sistem kendali cerdas yang digunakan untuk menghasilkan keputusan adalah kendali Logika Fuzzy dengan metode mamdani. Berdasarkan hasil pengujian dapat disimpulkan bahwa sistem pengolahan citra ini dapat bekerja sesuai dengan prinsip yang telah dirancang. Hal ini dibuktikan dengan prosentase keberhasilan sistem sebesar 76%.
Towards Ethical Conception in Legal Regulation of Vaccination in the Russian Federation
Authors: Iosifovna Kubar Olga , Georgievna Asatryan Asmik , Vladimirovna Roshchina Maria , Ljvovna Mikirtichan Galina , Evgenievna Nikitina Anastasia
Published: December 2019

Today the ethical aspect became the cornerstone of all public discussion defining the success of vaccination all over the world. This situation had a basic influence on formatting the modern normative regulation connected with vaccination by the inclusion of the universal ethical principals in the legislative concept. It is also extremely important to reach an understanding and recognition of these fundamental bases among responsible professional community and public society in general. Another significant impact is also to get harmonization and solidarity between existing national legislation and international ones. These provisions defined the main objective of this article to analyze the role and value of the ethical component in the current legislation in the Russian Federation connected with vaccination. First, the significance of universal ethical principles in the process of vaccine’s R&D and practical vaccination is presented (Chapter I). Secondary, the legal system of the Russian Federation is analyzed considering the compliance and the possibility of executing various ethical standards (Chapter II). Third, the author’s research based on a questionnaire survey held among the various categories responsible for vaccination, an imbalance of knowledge, and the implementation of basic ethical-normative principles are shown (Chapter III). The main conclusion of the article is the confirmation of the compliance between Russian legislation and the universal principles of bioethics. At the same time, there is an urgent need for education and awareness in order to improve the scientific and practical achievements of vaccination and to get the real adaptation of an ethical concept among professional society, as well as to reach the public trust.
Genetički modificirane biljke – bioetički pristup
Authors: Kaluđerović Željko
Published: December 2019

Biotehnologija, genetički inženjering, transgeni ili genetički modificirani organizmi (GMO) izazivaju brojne kontroverze širom zemljine kugle u posljednjih dvadesetak godina. Znanstvene studije o produkciji i upotrebi GMO-a, premda nemaju jednoznačan aksiološki predznak niti nude simplificirane odgovore na iskazane dileme, pokazuju da GM hrana donosi mogući rizik po ljudsko zdravlje, štetan utjecaj na okruženje i generalno pogoršanje kvalitete poljoprivrednih kultura. Ovome treba dodati i klasična bioetička pitanja u vezi s potencijalno nenadoknadivom štetom koju sadašnjoj, ali i budućim generacijama, može donijeti na ovakav način izmijenjeno biološko nasljeđe. Implementacija ove, kako je njeni pobornici nazivaju, najbrže usvojene biljne tehnologije u modernoj historiji čovječanstva, ugrožava, sa socijalne strane gledano, tradicionalnu poljoprivrednu proizvodnju i produbljuje i onako veliku društvenu nejednakosti između bogatih i siromašnih farmera. Evidentne su, također, intervencije velikih država i biotehnoloških kompanija prilikom donošenja ili korigiranja odgovarajućih zakona i uredbi o GMO-u, koje, iako deklarativno naglašavaju opće potrebe i zajedničku dobrobit, ustvari (ne)vješto prikrivaju vlastite partikularne interese. Analize mnogih znanstvenika i bioetičara, konačno, pokazuju da teza da će „genska revolucija” riješiti problem gladi u svijetu jednostavno nije dokazana u protekla dva desetljeća.