bluuebunny/crossref_metadata_2025 huggingface dataset:
A retrospective cohort study of telephone versus face-to-face clinics for the management of new otology referrals
Authors: Metcalfe Christopher , Gaskell Peter , McLelland Thomas , Patel Sanjay , Muzaffar Jameel , Dalton Lucy , Coulson Chris
Published: June 2022

Objectives: To compare outcomes of telephone and face-to-face
consultations for new otology referrals and discuss the wider use of
telemedicine in otology. Design: Retrospective cohort study. Setting: UK
secondary/tertiary referral unit. Participants: New adult otology
referrals to our unit, sampled consecutively between March 2021 and May
2021, reviewed in either a face-to-face or telephone clinic. Main
outcome measures: Primary outcome measure was the proportion of patients
with a definitive management outcome (discharged or added to waiting
list for treatment) versus the proportion of patients requiring
follow-up for further assessment or review. Results: 150 new patients
referred for a routine otology consultation (75 telephone, 75
face-to-face) were included. 53/75 patients (71%) undergoing a
face-to-face consultation received a definitive outcome following
initial review, versus 22/75 (29%) telephone patients (2
<0.001, OR 5.8). 52/75 (69%) telephone patients were followed
up face-to-face for examination. The mean (SD) number of appointments
required to reach a definitive outcome was 1.22 (0.58) and 1.75 (0.73)
in the face-to-face and telephone cohorts respectively
(p<0.001). Conclusion: Telephone clinics in otology have
played an important role as part of the COVID19 response. However, they
are currently limited by a lack of clinical examination and audiometry.
Remote assessment pathways in otology that incorporate asynchronous
review of recorded examinations alongside audiometry, either
conventional or boothless, may mitigate this problem, however further
research is required.
Clinical Characteristics and Predictors of Impaired Neonatal Outcomes in Chorioamnionitis at Term Gestation: A cross-sectional cohort study
Authors: Berg Patricia , Granfors Michaela , Riese Charlotta , Mantel Ängla
Published: June 2022

Objective: To describe clinical and laboratory characteristics
of term deliveries complicated by chorioamnionitis, and to assess their
association with adverse neonatal outcomes. Design:
Cross-sectional cohort study Setting: The study is based on
data from the Swedish Pregnancy Register, enriched with clinical data
extracted from medical charts. Population and Sample: A random
sample of 500 term singleton deliveries in Stockholm County with
registered diagnosis of chorioamnionitis in the Swedish Pregnancy
Register between 2014 and 2020. Methods: Logistic regression
was used to estimate odds ratios (OR) as a measurement of the
association between clinical and laboratory characteristics and neonatal
complications Main Outcome Measures: Neonatal infection and
asphyxia-related complications. Results: Maternal fever,
maternal and fetal tachycardia, and elevated inflammatory laboratory
markers were frequent signs of chorioamnionitis. The prevalence of
neonatal infection and asphyxia-related complications was 10 and 22%,
respectively. First leukocyte count in the second tertile (OR 2.14
[95% CI 1.02-4.49]), maximum CRP level in the third tertile (OR
4.01 [95% Cl 1.66-9.68]), and positive cervical culture (OR 2.22
[95% Cl 1.10-4.48]) were associated with an increased risk of
neonatal infection. Maximum level of CRP in the third tertile (OR 1.93
[95% Cl 1.09-3.41]), and fetal tachycardia (OR 1.63 [95% Cl
1.01-2.65]) were associated with increased risk of asphyxia-related
complications. Conclusions: In addition to maternal intrapartum
fever, maternal and fetal tachycardia, and elevated inflammatory
laboratory markers were common signs of chorioamnionitis. Elevated
inflammatory laboratory markers were associated with both neonatal
infection and asphyxia-related complications, and fetal tachycardia was
associated asphyxia-related complications.
Outcomes of Lymphadenectomy for Early-Stage Mucinous Ovarian Cancer: A Retrospective Study Based on Surveillance, Epidemiology, and End Results (SEER) Database
Authors: Cheng Xiaqin , Zeng Zhen , Cui Lanyue , Li Jundong
Published: June 2022

Objective: To evaluate the efficacy of lymphadenectomy for early-stage
primary mucinous ovarian cancer (MOC). Design: Retrospective observation
study Setting: Surveillance, Epidemiology, and End Results (SEER)
database for 2000-2018 Population or sample: The study population
comprised 1848 patients with early-stage MOC Methods: MOCs were divided
into two groups according to lymphadenectomy. Propensity score matching
were performed to correct for deviations. Independent risk factors for
overall survival (OS) were determined by multivariate analysis using Cox
regression. The role of lymphadenectomy was performed in different
populations by stratified analysis applying interaction analysis. OS was
calculated by Kaplan-Meier curves and compared by log-rank test. Main
outcome measures: Overall survival Results: In the study, almost 65.8%
(n = 1214/1848) experienced lymphadenectomy. Lymphadenectomy (HR =
0.692, 95% CI = 0.516-0.927, P = 0.009), age at diagnosis (HR = 3.028,
95% CI = 1.477-6.208, P = 0.002), and laterality (HR = 2.013, 95% CI =
1.145-3.54, P = 0.015) were found to be associated with OS. The role of
lymphadenectomy varied by age group and tumor laterality, and the 5-year
survival rates of patients with bilateral tumors who had experienced
lymphadenectomy with sampling and dissection, or for MOC over age 50 and
were higher than that of patients who did not undergo lymphadenectomy.
Conclusion: Lymphadenectomy with sampling and dissection has little
impact on OS in patients with early MOC. Lymph node therapy can be
discontinued in patients younger than 50 years, and lymph node sampling
is recommended for patients older than 50 years or with bilateral
tumors.
Non-sinusoidal micro-Doppler components extraction based on dual-branch network
Authors: Lu Jie , Zhang Wenpeng , Liu Yongxiang , Yang Wei
Published: June 2022

Fine target status can be represented by the extracted micro-Doppler
(m-D) components from the radar echo. However, current methods do not
consider the specialty of the m-D components and their performance to
irregular components are poor. In this paper, neural network is applied
to m-D signal extraction for the first time. Specifically, a novel and
effective dual-branch network based m-D components extraction method is
proposed. The dual-branch network consisting of a continuous m-D
components extraction branch and a crossing point detection branch is
designed to obtain components and cross points at the same time. To
solve the error correlation problem of multi-component signals, the
first-order parametric continuous condition and cubic spline
interpolation are employed to obtain complete and smooth components
curves. Simulation and measurement results show that this method of good
robustness is a good candidate to separate the non-sinusoidal m-D
components with intersections.
New evidence for seed transmission of reptiles in arid areas of China
Authors: Duan Zhenyuan , Shi Lei
Published: June 2022

Abstract: Diet and trophic niche of Teratoscincus roborowskii was
analyzed by pellets analysis technique. A total of 263 pellets of
Teratoscincus roborowskii were collected from the Turpan Botanic Garden
in Turpan City from July to Octobor, 2016, . Food composition and
proportion of Teratoscincus roborowskii were identified by comparative
analysis. The number of food components in the fecal samples was
identified, and the numeric frequency, biomass ratio and frequency of
occurrence of each component were counted and then the monthly
Shannon-wiener diversity index, Shannon evenness index and diet niche
width were analyzed. The results show that the Teratoscincus roborowskii
mainly feed on insects and caper fruit in the Turpan Botanic Garden.
Insects are the most common food for the Teratoscincus roborowskii, the
frequency of occurrence which in each month is the largest; caper fruit
was the most food intake in July and August, and that of insects is the
most one on September and October. There are some differences in the
composition of food in different months, which may be related to changes
of food availability. The results of the feeding habit analysis show
that the Teratoscincus roborowskii may play an active role in the
dispersal of caper seed.
Hyperinsulinemia Is Highly Associated With Markers of Hepatocytic Senescence in Two Independent Cohorts
Authors: Meijnikman Abraham S. , van Olden Casper C. , Aydin Ömrüm , Herrema Hilde , Kaminska Dorota , Lappa Dimitra , Männistö Ville , Tremaroli Valentina , Olofsson Louise E. , de Brauw Maurits , van de Laar Arnold , Verheij Joanne , Gerdes Victor E.A. , Schwartz Thue W. , Nielsen Jens , Bäckhed Fredrik , Pajukanta Päivi , Pihlajamäki Jussi , Tchkonia Tamar , Kirkland James L. , Kuipers Folkert , Nieuwdorp Max , Groen Albert K.
Published: June 2022

Cellular senescence is an essentially irreversible growth arrest that occurs in response to various cellular stressors and may contribute to development of type 2 diabetes mellitus and nonalcoholic fatty liver disease (NAFLD). In this article, we investigated whether chronically elevated insulin levels are associated with cellular senescence in the human liver. In 107 individuals undergoing bariatric surgery, hepatic senescence markers were assessed by immunohistochemistry as well as transcriptomics. A subset of 180 participants from the ongoing Finnish Kuopio OBesity Surgery (KOBS) study was used as validation cohort. We found plasma insulin to be highly associated with various markers of cellular senescence in liver tissue. The liver transcriptome of individuals with high insulin revealed significant upregulation of several genes associated with senescence: p21, TGFβ, PI3K, HLA-G, IL8, p38, Ras, and E2F. Insulin associated with hepatic senescence independently of NAFLD and plasma glucose. By using transcriptomic data from the KOBS study, we could validate the association of insulin with p21 in the liver. Our results support a potential role for hyperinsulinemia in induction of cellular senescence in the liver. These findings suggest possible benefits of lowering insulin levels in obese individuals with insulin resistance.
Changes in Glucose Metabolism and Glycemic Status With Once-Weekly Subcutaneous Semaglutide 2.4 mg Among Participants With Prediabetes in the STEP Program
Authors: Perreault Leigh , Davies Melanie , Frias Juan P. , Laursen Peter Nørkjaer , Lingvay Ildiko , Machineni Sriram , Varbo Anette , Wilding John P.H. , Wallenstein Signe Olrik Rytter , le Roux Carel W.
Published: June 2022

OBJECTIVE

This analysis of 3,375 adults with overweight/obesity across the Semaglutide Treatment Effect in People with obesity (STEP) 1, 3, and 4 trials evaluated whether more participants with prediabetes had normoglycemia after 68 weeks’ treatment with once-weekly semaglutide 2.4 mg plus lifestyle intervention versus placebo and assessed changes in glucose metabolism in participants with prediabetes.

RESEARCH DESIGN AND METHODS

STEP 1, 3, and 4 were phase 3, 68-week, randomized, placebo-controlled, multinational trials; STEP 4 had a 20-week semaglutide run-in and 48-week randomized period. Analyses included changes (week 0–68; before the washout period) in glycemic status (prespecified: STEP 1 and 3; post hoc: STEP 4), and in HbA1c, fasting plasma glucose (FPG), and HOMA insulin resistance (HOMA-IR) among participants with prediabetes (post hoc).

RESULTS

Significantly more participants with baseline (week 0) prediabetes (n = 1,536) had normoglycemia at week 68 with semaglutide versus placebo (STEP 1, 84.1% vs. 47.8%; STEP 3, 89.5% vs. 55.0%; STEP 4, 89.8% vs. 70.4%; all P < 0.0001). Fewer participants with baseline normoglycemia had prediabetes at week 68 with semaglutide versus placebo (STEP 1, 2.9% vs. 10.9%; STEP 3, 3.2% vs. 5.8%; STEP 4, 1.1% vs. 5.0%). Semaglutide resulted in greater improvements in HbA1c, FPG, and HOMA-IR than placebo among participants with baseline prediabetes (all P < 0.01).

CONCLUSIONS

STEP 1, 3, and 4 collectively provide a robust assessment of the effects of semaglutide on glucose metabolism and prediabetes in a large cohort of adults with overweight/obesity while on treatment. Among participants with baseline prediabetes, 68 weeks’ treatment with semaglutide versus placebo led to significant improvements in glucose metabolism and a higher likelihood of normoglycemia.
Relationship between Sciences and Education Lecturers’ Perceived Use of Mobile Technologies for Instruction
Authors: Alani Taye Rasheed Rasheed , Obielodan Omotayo Olabo , Onojah Amos Ochayi , Omotayo Aderele Shadrack , Onojah Adenike Aderogba , Alasan Ndaceko Joel
Published: June 2022

Mobile technologies enable both education and science lecturers to provide the educational materials to their students on mobile technologies. But many science and education lectures educators were likely not using mobile technology to its maximum potential. The objectives were to examine the relationship between science and education lecturers and the effect of specialisation in the use of mobile technologies for instruction. The study was a descriptive research of survey type. 160 respondents were randomly selected for this study from the faculty of science and education. Frequency, percentage, multiple regression, and ANOVA were used for the analysis. The findings established that a positive relationship exists between science and education lecturers in the use of mobile technologies for instruction. It was recommended that lecturers should be encouraged to explore different ways in which mobile technologies can be used in teaching and learning.
Comparison of Vegetation Index Method to Detect Drought in Bondowoso Regency, East Java
Authors: Aziz Yuda Aulia , Nugraha A Sediyo Adi
Published: June 2022

Drought in Bondowoso County has the potential to occur sustainably with diverse topographic variations. This study aims to determine drought conditions by using a vegetation index with a multi-temporal Landsat 8 OLI image from January-July 2021. The vegetation index methods used are SAVI (Soil Adjusted Vegetation Index), EVI (Enhanced Vegetation Index), and NDVI (Normalized Difference Vegetation Index). The three vegetation indices were chosen because they provide different vegetation sensitivities. The results showed that all three vegetation indices provided a slight difference inaccuracy. SAVI has an accuracy result of 86%, EVI with 14% accuracy, and NDVI has 80% accuracy. The difference in accuracy results from the condition of Bondowoso Regency with a variety of vegetation. Temporally also showed that SAVI is more sensitive to vegetation information, especially in areas close to clouds, than in EVI and NDVI. It can be concluded that SAVI can provide drought information better than EVI and NDVI.
Metodología de administración para el mantenimiento preventivo como base de la confiabilidad de las máquinas
Authors: Pillado Portillo Martín , Castillo Pérez Velia Herminia , De la Riva Rodríguez Jorge
Published: June 2022

El mantenimiento preventivo comprende todas las actividades involucradas en la conservación en buen estado de los equipos tecnológicos de cualquier empresa. En la actualidad, la implementación del mantenimiento preventivo dentro de la industria es fundamental para minimizar las averías en la maquinaría. Este estudio muestra el sistema de mantenimiento preventivo como un elemento clave del proceso general de las organizaciones. Mediante un diagrama de flujo se muestran los diferentes pasos a seguir para implementar y mantener un sistema de este tipo. La metodología propuesta se implementó en una empresa que fabrica productos médicos y entre los resultados se registró una mejora del tiempo medio entre fallas de 1.176 horas a 1.699 horas y la eliminación de variaciones entre programas de 79.5 horas a solo 17 horas, entre otros. Este artículo muestra el entramado de los elementos clave del mantenimiento preventivo total: desde técnicas de mantenimiento, pasando por la efectividad del equipo, la estandarización de las prácticas de mantenimiento, el encuadre del mantenimiento preventivo total, hasta las barreras, limitaciones y éxitos del mantenimiento preventivo.
STRATEGIC PLANNING OF RESILIENT AND REGENERATIVE CITIES
Authors: Gasperin Daniela , Patrícia Ganzer Paula , Catarina Dib Vitória
Published: June 2022

Resilience is a process in which communities collectively respond to significant events, using various coping and adaptive capacities. This scenario has mobilized reflections and strategies on the need to build resilient and regenerative cities with the capacity to recover from disasters and sustainably adapt to changes. The ecosystemic view of resilience perceives the individual incorporated into a web of complex relationships so that the individual, the family, and the environment are interconnected, and each sphere contributes to coping with adversities. This qualitative research was outlined in a case study conducted online with 200 individuals, of which 150 are students aged 11 to 13 years and 50 teachers, from four municipal schools. The research answered the following question: How does the knowledge of feelings and the ways of dealing with them in adolescents and teachers influence the development of a resilient and regenerative city? Content analysis was applied to analyze the data with the aid of the software NVivo version 20. The research was conducted through the Quality of Life Project Knowing the Feelings promoted by the Resilient City Program in the Municipality of Veranópolis in the State of Rio Grande do Sul, Brazil. The results showed the importance of the project for people’s lives and the understanding of their feelings for developing themselves and strengthening resilience. The preparation to exercise citizenship begins with the knowledge about oneself and the environment in which one lives, aiming to interpret and act in society responsibly and, in this process, build a resilient and regenerative community.
Análise de risco e gerenciamento de desastres: estudo comparativo entre as políticas públicas brasileira e colombiana
Authors: Feldens Nathani Eduarda de Andrades , Daronco Giuliano Crauss
Published: June 2022

Nas últimas décadas os Desastres Naturais constituem um tema cada vez mais presente no cotidiano das populações. Eles têm ocorrido com mais frequência no Brasil nos últimos anos, além disto estão aumentando de intensidade e periodicidade, provocando óbitos e danos materiais. A posição geográfica da Colômbia, a dinâmica da natureza e a maneira como as comunidades colombianas ocuparam seus ecossistemas, determinam que cada vez se apresentem mais desastres no país. Neste trabalho desenvolveu-se uma comparação entre as políticas públicas brasileira e colombiana, relativas ao gerenciamento de desastres, indicando os itens de maior ou menor relevância nas ações de prevenção, preparação, resposta e reconstrução.
Seleção de um conjunto de indicadores com base nas ISOs 9001, 14001 e 16001 aderentes às micro e pequenas empresas
Authors: Reiter Iane de Brito , Feil Alexandre André
Published: June 2022

A utilização integrada das normas ISO 9001, 14001 e 16001 como estratégia para melhorar o desempenho da gestão por intermédio de indicadores pode ser uma possibilidade de as organizações avançarem em direção à sustentabilidade. Neste contexto, este estudo objetivou identificar e selecionar um conjunto de indicadores com base nas ISOs 9001, 14001 e 16001 para auxiliar na gestão de forma integrada das micro e pequenas empresas em direção a sustentabilidade. Os procedimentos metodológicos na condução desta pesquisa em relação à abordagem foram qualiquantitativa, descritiva, e quanto aos procedimentos técnicos utilizou-se a pesquisa documental, bibliográfica e survey. A amostra da pesquisa survey (questionário) com escala likert de cinco pontos, não é probabilística e escolhida por conveniência, de 125 gestores de micro e pequenas empresas. Os principais resultados revelam que o perfil dos respondentes se mostrou qualificado e com experiência na gestão das organizações em função do elevado nível de escolaridade e do tempo de atividade.  O conjunto de indicadores selecionados, com base no nível de consenso, totalizam 35, distribuídos em sete indicadores ambientais, 13 indicadores sociais e 15 indicadores econômicos e de gestão. Este conjunto de indicadores abrange de forma holística as micro e pequenas empresas e seus stakeholders podendo auxiliar na gestão em direção a sustentabilidade.
PENGEMBANGAN MEDIA AUDIO VISUAL BAHASA INDONESIA BERBASIS HOTS MATERI HIDUP BERSIH DAN SEHAT (Penelitian Design and Development di Kelas II SD Negeri Kedokan)
Authors: Namiroh Salma
Published: June 2022

Abstract This research is motivated by the lack of procurement of variety of learning media integrated with technology in thematic learning of clean and healthy living materials, especially in Indonesian language learning. This makes students find it difficult to receive learning materials. In addition, the demands of 21st century education also require integrating learning with technology and developing high-level thinking skills or HOTS. Based on this, the researcher intends to develop indonesian audio visual media based on HOTS clean and healthy living materials for students of grade II of Kedokan State Elementary School. This research uses design and development methods with addie model. Based on the results of validation provided, the research products that have been developed by researchers fall into the category of "Very Worthy" with a percentage of eligibility of 94% of material experts and 86.75% of media experts. The use of HOTS-based Indonesian audio visual media also received a positive response from teachers and students of grade II of Kedokan State Elementary School who were participants in this study, with a percentage of media eligibility scores of 100% from teachers and 94.25% of students.Keywords: 21st Century Education, Media Development, Audio Visual Media, Higher Order Thinking Skills AbstrakPenelitian ini dilatarbelakangi oleh minimnya pengadaan variasi media pembelajaran yang terintegrasi dengan teknologi pada pembelajaran tematik materi hidup bersih dan sehat, khususnya pada pembelajaran Bahasa Indonesia. Hal tersebut membuat siswa merasa kesulitan dalam menerima materi pembelajaran. Disamping itu, tuntutan pendidikan abad ke-21 juga mengharuskan pengintegrasian pembelajaran dengan teknologi serta mengembangkan keterampilan berpikir tingkat tinggi atau HOTS. Berdasarkan hal tersebut, maka peneliti bermaksud untuk mengembangkan media audio visual Bahasa Indonesia berbasis HOTS materi hidup bersih dan sehat untuk siswa kelas II SD Negeri Kedokan. Penelitian ini menggunakan metode Design and Development dengan model ADDIE. Berdasarkan hasil validasi yang diberikan, maka produk penelitian yang telah dikembangkan oleh peneliti termasuk ke dalam kategori “Sangat Layak” dengan presentase kelayakan sebesar 94% dari ahli materi dan 86,75% dari ahli media. Penggunaan media audio visual bahasa Indonesia berbasis HOTS juga mendapatkan respon positif dari guru dan siswa kelas II SD Negeri Kedokan yang menjadi partisipan dalam penelitian ini, dengan nilai presentase kelayakan media sebesar 100% dari guru dan 94,25% dari siswa.Kata Kunci: Pendidikan Abad ke-21, Pengembangan Media, Media Audio Visual, Higher Order Thinking Skills
Pengaruh Motivasi Siswa dan Sosial Ekonomi Orang Tua Terhadap Prestasi Belajar Siswa SDN 001 Bulang Kota Batam
Authors: Razak A , Fauzi Muhammad Amin , Sudarmo Agnes Puspitasari
Published: June 2022

The purpose of this study is to analyze the influence of student motivation on student achievement, the socio-economic influence of students' parents on student achievement, and the influence of motivation and socioeconomic of parents on student achievement of SDN 001 Bulang Batam City simultaneously. This research was conducted on 66 students. This quantitative study used a survey method with path analysis techniques. Sampling based on the Roscoe technique, using a Likert scale questionnaire that has been compiled and analyzed by six instrument validators and tested for validity and reliability. From the results of the calculation of the influence of student motivation on student achievement with a significance of 0.000 <0.05, the direct effect of motivation on student achievement is 0.5%, the undirect effect is 2.1% while the overall effect is 2.6%. This means that the motivation variable has a significant effect on student achievement. The socio-economic influence of parents on student achievement with a significance of 0.000 <0.05, the direct effect of socio-economy on student achievement is 31.1% and the undirect effect is 2.1% while the overall effect is 33.3%, this means that Parents' socio-economic variables significantly influence student achievement. The effect of motivation and socio-economy together on student achievement with a significance of 0.000 <0.05, the direct effect of student motivation and socio-economic of parents of students together on student achievement is 31.6% and the undirect effect is 4.2% while the overall effect was 35.9%. From the results of the simultaneous calculation of the hypothesis test (Ftest), the value of Fcount = 13.766 and it is known that the value of Ftable = 3.09. Then the value of Fcount = 13.766> Ftable = 3.09. This shows that there is a significant effect with a significance level of 0.000 <0.05. Therefore Ho is rejected and H3 is accepted. This means that there is a significant influence between the variables of student motivation and the socio-economic of students' parents variable simultaneously on the learning achievement of elementary school students in District of Bulang , Batam City.
Disseminated Hematogenous Tuberculosis after Spontaneous Abortion
Authors: Cheyney Sarah , Ow Rena , Verdick Crystal , Reischmann Mary , Carlan Stephen
Published: June 2022

Disseminated tuberculosis is a mycobacterial infection that either involves the blood, bone marrow, liver or two or more noncontiguous sites. While tuberculosis is not uncommon in pregnancy, active, disseminated tuberculosis is exceedingly rare and is associated with poor maternal and fetal outcomes including a ninefold increase in miscarriage. Symptoms of both disseminated tuberculosis in pregnancy can be vague and nonspecific making it difficult to diagnosis. A 20-year-old, immune competent female presented with worsening dyspnea over two months and cavitary lesions on chest imaging. She had been treated with oral antibiotics two months prior and was noted to have an early intrauterine pregnancy at the time. She subsequently miscarried spontaneously. PCR (polymerase chain reaction) testing from brochoalveolar lavage isolated Mycobacterium Tuberculosis. A liquid biopsy (Karius) was positive for Cytomegalovirus, Herpes Simplex Virus 1, and Candida Albicans. The patient had a prolonged and complicated treatment course and ultimately was discharged to inpatient rehabilitation. Disseminated tuberculosis is associated with significant mortality and morbidity warranting prompt treatment with clinical suspicion. Treatment should start when active TB is diagnosed in pregnancy regardless of the trimester. The prenatal care giver is in a unique position to screen and support women who otherwise may not interact with a structured healthcare system.
Black Soybean (Glycine max (L.) Merr.) 30% Ethanol Extract Cream Inhibited The Increase of Tyrosinase Enzyme Expression and The Amount of Melanin Same Effective as 4% Hydroquinone Cream on Guinea Pig (Cavia porcellus) Skin
Authors: Johan Yanvi , Wiraguna Anak Agung Gde Putra , Dewi Ni Nyoman Ayu
Published: June 2022

Background: Hyperpigmentation is one of the signs of skin aging which is mostly caused by Ultraviolet B (UVB) rays exposure. The gold standard for hyperpigmentation therapy is hydroquinone (HQ) but its long-term use can cause side effects such as irritation, rebound phenomenon, and even ochronosis. Black soybeans contain active ingredients that can prevent the increase of tyrosinase enzyme and the amount of melanin so that it can be used as an alternative therapy for hyperpigmentation. This study aims to prove that the administration of 30% black soybean extract cream was as effective as 4% HQ cream in inhibiting the increase of tyrosinase enzyme expression and the amount of melanin in guinea pig skin exposed to UVB rays.

Methods: This study used a post-test only control group design method with 30 guinea pigs as samples. The sample was divided into three groups of 10 each. The P1 group was given the base cream, the P2 group was given the 4% HQ cream, while the P3 group was given the 30% black soybean extract cream. Each group was exposed to UVB rays with a total dose of 390mJ/cm2 for 2 weeks, after that the guinea pig skin tissue was taken and histopathological preparations were made for examination of tyrosinase enzyme expression and the amount of melanin. The data obtained were analyzed using one way ANOVA, then the differences between groups were analyzed using the Least Significant Difference (LSD) test.

Results: The results showed that the mean of the tyrosinase enzyme expression and the amount of melanin in the black soybean extract group P3 (12.880±3.327% and 3.16±1.486) were not significantly different from the HQ4% group P2 (9.690±2.176% and 2.18±1.117), while the mean of the base cream group P1 (25.78±5.392% and 12.080±3.150) was the highest among the three groups. The LSD test showed a significant difference between the base cream group (P1) and the other groups (p<0.01), but there was no significant difference between the 4% hydroquinone group (P2) and the 30% black soybean extract treatment group (P3) (p >0.05).

Conclusion: The conclusion of this study was that 30% black soybean ethanol extract cream inhibited the increase of tyrosinase enzyme expression and the amount of melanin as effective as 4% HQ cream on guinea pig skin exposed to UVB light.
Evaluation of Mycotoxin Contaminations Across Beans Food Chain in Eswatini
Authors: Earnshaw Marie Diana , Dlamini Cyril , Dlamini Bongiwe Porri , Assefa Yoseph
Published: June 2022

Mycotoxins are naturally occurring toxic secondary metabolites produced by filamentous fungi contaminating various food and feed crops. Exposure to mycotoxins has been associated with mycotoxicosis, which accounts for a high percentage of diseases in developing countries where methods of food handling and storage are inadequate. For the first time, this study determined the diversity, prevalence and co-occurrence of mycotoxins across the beans value chain in Eswatini. A total of 226 beans samples received between 2001 and 2021 by mycotoxin laboratory at Malkerns research were analysed and more than 59.3% of the samples were found contaminated with mycotoxins. Results confirmed that aflatoxins (AFs) and Zearalenone (ZEN) were the main contaminating mycotoxins in beans. These mycotoxins occurred singly and co-occurred as mixtures in the samples analysed. Considerable differences regarding the prevalence of these mycotoxins were observed between samples from different beans value chain actors and between sampling years. Implications of the results on the pre and postharvest handling of beans in Eswatini and the health hazard that mycotoxins pose to humans and animals were discussed. The importance of clear and enforceable regulations on levels of mycotoxin in beans and other dietary products is emphasised and the need for research on the deleterious effects of mycotoxins and their metabolites on animal and human health is underlined.
Analysis of The Factors Causing Accidents at Level Crossings in the Area of PT Kereta Api Indonesia (Persero) Daop 1 Jakarta
Authors: Foenale Chano Benawan , Nugroho Rosalendro Eddy
Published: June 2022

The volume of train trips which every day reaches 1,300 trips causes a high intensity of encounters between trains and other vehicles at level crossings. This raises the potential for accidents involving trains and other vehicles as well as with humans. This study aims to determine the factors that cause accidents, reduce the number of accidents, and improve the safety system at level crossings in the Daop 1 Jakarta area. Qualitative descriptive research method with a population of accidents at level crossings of the PT KAI (Persero) Daop 1 Jakarta in 2016-2019. The number of samples used is 198 accidents with a chronological investigation of accidents. Analysis using Human Factor Classification and Analysis System (HFACS) followed by Fishbone Analysis and 5Whys Analysis. The factors that cause accidents by motorists are unsafe behavior, namely making errors in crossing and violations that are not in accordance with procedures. Factors causing accidents by pedestrians, namely unsafe behavior such as errors and violations committed and pedestrian conditions that do not support crossing. Dis-semination of regulations and laws, procedures for crossing, appeals, and warnings not to carry out dangerous activities at crossings can also be carried out to reduce accidents. Repair of damaged or old facilities with facilities that are in accordance with regulations and making new crossing procedures so that they can be more adhered to are suggestions for improving the safety system.
Between Uncertainty, Submission and Hope - Experiences and Reflections on Waiting by Theater Migrants
Authors: Szymanski-Düll Berenika
Published: June 2022

While flight and exile are primarily associated with movement, this article aims to examine their static side, focusing on the element of waiting in the refugee and exile processes of theatre migrants. Examining the memoirs of the playwright, theatre manager and journalist, Heinrich Börnstein (1805–1892), and the documentary stage production What They Want to Hear (2018, Kammerspiele München) by the Argentinian director Lola Arias, it seeks to identify the subjective experiences of waiting of individual theatre makers and asks how they are configured in different settings and over time, in specific geographic and political locations. These subjective experiences of theatre migrants viewed through the analytical lens of waiting provide – as will be shown – crucial insights into social organising principles and power hierarchies.
Sprache und Hierarchie. Die Möglichkeit des Widerstands in internationalen Koproduktionen des Regisseurs Suzuki Tadashi
Authors: Terao Ehito
Published: June 2022

Suzuki Tadashi (*1939) gehört zu den wichtigsten Theaterkünstler*innen in Japan. Er hat sein eigenes Schauspieltraining, die ‚Suzuki-Methode‘, entwickelt und sich in seinen Inszenierungen mit der De- und Rekonstruktion des Verhältnisses von Körper und Sprache beschäftigt. Im Jahr 2009 ließ der Regisseur in seiner Produktion Haisha-Nagaya no Kachi Kachi Yama, anders als in seinen bisherigen zahlreichen internationalen Produktionen, alle ausländischen Schauspieler*innen in japanischer Sprache spielen. In dieser Situation verfremden ihre Gesten und Sprechweisen die Selbstverständlichkeit der Sprache: Sie machen einen Sprach- und Kulturraum sichtbar, in dem die sprachliche, soziale und kulturelle Hierarchie ohne Gründe und als kollektive Phantasie entsteht. Im Spielraum der formalen Kollektivität bzw. der kollektiven Formalität zeigen sich markante Momente, mit denen die Grenzen der bestimmten Sprach- und Kulturräume überschritten und eine neue Möglichkeit der transkulturellen Schauspielkunst gezeigt werden.
Clinical and morphological features of non-small cell lung cancer in patients with different types of histological changes to the bronchial epithelium
Authors: Zavyalova MV , Loos DM , Pismenny DS , Durova AA , Pankova OV , Rodionov EO , Tuzikov SA , Tashireva LA , Perelmuter VM
Published: June 2022

Lung cancer occupies the leading position in the global structure of oncological diseases. Despite significant advances in its treatment, the survival remains low. Morphological changes to the bronchial epithelium outside the tumor may provide important cues on progression of the disease in patients with lung cancer. This study aimed to identify associations between morphological and clinical features of non-small cell lung cancer and morphological changes to the epithelium in small bronchi outside the tumor. The study encompassed tumor specimens collected from 90 patients, 75 (83%) men and 15 (17%) women, diagnosed with non-small cell lung cancer. The average age of the patients was 67.8 ± 7.4 years. The results indicate higher frequency of lymphogenous metastasis in patients with combined basal cell hyperplasia and squamous metaplasia (BCH+SM+ group) compared to patients with isolated basal cell hyperplasia (BCH+SM– group, p = 0.05). The BCH+SM– group presented with higher rates of hematogenous metastasis compared to BCH+SM+ and BCH–SM– groups (p = 0.004 and p = 0.0019, respectively), as well as increased representation of low-differentiated structures in the primary tumors. The results suggest a commonality of parenchymal-stromal interactions in non-small cell lung cancers and their surroundings and a significant impact of these interactions on differentiation status and progression of the tumors.
Гипотеза об излучении неклассического света при импульсе рака-щелкуна: постановка и предварительный анализ
Authors: Макушевич Илья
Published: June 2022

Недавно опубликованы данные о том, что свет, излучаемый при сонолюминесценции, — неклассический. Это является существенным результатом, накладывающим значимые ограничения на гипотезы о еще недостаточно изученном механизме сонолюминесценции. Известно, что при импульсе клешни рака-щелкуна происходит кавитация, которая сопровождается сонолюминесценцией. Можно предположить, что раки-щелкуны являются природным источником неклассического света. Намечены пути проверки данной гипотезы.
Noticia del proyecto y construcción del ferrocarril Ribes-Queralbs-Núria, en el Pirineo de Girona
Authors: Gorini Santo Carles
Published: June 2022

La investigación en el fondo documental de la sociedad de Ferrocarriles de Montaña a Grandes Pendientes, S.A. (F.M.G.P.), que custodia Ferrocarrils de la Generalitat de Catalunya (F.G.C.), ha revelado la dimensión del proyecto de aquella sociedad en el valle de Núria, que se gestó entre 1924 y 1931, y que era en parte desconocido. También, ha proporcionado evidencias de  valor sobre las condiciones del trabajo durante la construcción de la línea y otras informaciones relativas a esa ejecución, como la característica de los contratistas y los proveedores. El trabajo que presentamos constituye, pues, una aportación al conocimiento de los procesos de planificación y ejecución de los ferrocarriles secundarios catalanes
Knowledge and Food Hygiene Practices among Food Handlers in Saifai Developmental Block of District Etawah: A Cross-Sectional Study
Authors:   Professor, Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India., Singh Naresh Pal
Published: June 2022

Background: Food safety knowledge (FSK) is the understanding of food learned from skills or schooling while food safety attitude (FSA) refers to sensation or belief about food safety, and food safety practice refers (FSP) to the act or use of food safety. In the absence of well-maintained and proper food handling practices in mass catering establishments, they have the potential to impart a disastrous effect on human health. This study was conducted with the aim to assess the knowledge and food hygiene practices among food handlers deployed in various food establishments in Saifai developmental block, Etawah district, Uttar Pradesh.Material and Methods: This cross-sectional study was conducted among all (109) the food handlers above 15 years age working at all the food establishments registered or unregistered with district administration in Saifai developmental block of district Etawah from September2020-October 2020. Results: Out of 76 eligible participants, 62 (81.5%) were males as compared to females 14 (18.5%). Majority of the food handlers 36 (47.3%) were aware that disease transmission was through contaminated water followed by contaminated hands (34.2%). 68 (89.4%). Responses of males and females on various questions related to food safety practices were found to be statistically significant (p<0.05) which shows a difference in knowledge of same question in males and females.Conclusion: Food-handlers in the study area had satisfactory knowledge related to food safety, general and personal hygiene, cleaning and sanitation procedures. However, this did not translate into strict food hygiene practices. Routine medical examination of food handlers must be carried by health officers.
Patient Satisfaction in Missionary Hospitals of Kerala
Authors:   Research Scholar, Bharathiar University, Coimbatore, Tamil Nadu, India., Mammen Pradeep V
Published: June 2022

Background: Kerala has become a success and a model for the country, especially in increasing life expectancy as well as reducing infant and maternal mortalities. But there is a wider demographic and epidemiological transition happened, which lead to higher morbidity rates and life style diseases. Considering health as a basic need and necessity, in this scenario of unregulated healthcare market, it is essential that along with public health services, missionary and other non-profit hospitals sustain themselves in this competitive health scenario. Methods: This is a descriptive cross-sectional study, done among the missionary hospitals under Catholic Church in Kerala. All the hospitals registered under CHAI - (Catholic Health Association of India) - Kerala Region is the statistical universe for this study. In the CHAI- Kerala region, there are 5 zones: Central zone, Kottayam zone, Trissur zone, Malabar zone and Trivandrum zone, covering all the regions of the State. The study was limited to 10 hospitals from 5 zones. The data was collected through questionnaire from 300 patients of 10 hospitals spread all over the State of Kerala. Results: With regard to the attention by the doctor, there was significant difference in terms of income, and about medical care there is significant difference on age and gender. There was also a difference of significance about the cost of treatment on income. And there was significant difference in diagnosis based on age and income. Conclusion: Understanding the factors that affect the patient perceptions of satisfaction in missionary hospitals can bring more insights in visioning quality improvement strategies in health care management.
Perancangan Kampanye Social Movement Bahaya Smartphone bagi Anak
Authors: Pravitasari Indriati Suci
Published: June 2022

Abstrak

Manusia sekarang ini tidak lepas dari sarana komunikasi yaitu smartphone, saat ini smartphone mengalami perkembangan yang sangat pesat terutama pada operasi sistem serta program dan aplikasi yang digunakan dalam setiap smartphone, yang dapat meningkatkan kemudahan operasi tiap smartphone. Berbagai perkembangan kemajuan tentu memiliki dua dampak, positif dan negatif. Berbagai fitur dan aplikasi canggih yang ditawarkan dalam smartphone penggunanya betah berlama-lama menatap layar dalam waktu yang cukup lama. Fungsi smartphone kini tidak hanya sebagai sarana komunikasi semata, namun berubah sebagai gaya hidup. Para pengguna smartphone tidak hanya di kalangan usia dewasa dan remaja saja namun, kini sudah sampai pada anak-anak, padahal anak-anak belum mampu memfilter dan membedakan mana yang baik dan tepat bagi dirinya, pada berbagai kecanggihan pada fitur-fitur smartphone. Pada perancangan ini maka pendekatan komunikasi visual dengan menggunakan sosial media, selain layak diterapkan juga dinilai tepat dalam mengikuti arus perkembangan smartphone, dan sosial media merupakan media kampanye yang paling ampuh sebagai sarana dalam menjembatani sebuah pesan bagi target audience dalam perancangan ini.

Abstract

Humans today are inseparable from the means of communication, smartphones, nowadays smartphones are experiencing very rapid development, especially in operating systems and programs and applications used in each smartphone, which can improve the ease of operation of each smartphone. Various developments in progress certainly have two effects, positive and negative. Various advanced features and applications offered in the smartphone, the users feel at home for a long time staring at the screen for quite a long time. The function of smartphone now is not only a means of communication, but changes as a lifestyle. Smartphone users are not only among adults and adolescents, but now it has reached children, even though the children have not been able to filter and differentiate what is good and right for themselves, on the various sophistication of smartphone features. In

this design the visual communication approach using social media, in

addition to being feasible to be applied is also considered appropriate in

following the development of smartphones, and social media is the most powerful campaign media as a means of bridging a message for the target audience in this design.
Bunga Anggrek Hitam sebagai Ide Penciptaan Karya Batik pada Kain Tenun Ulap Doyo (Black Orchid Flower as an Idea for the Creation of Batik in Doyo Ulap Woven Fabrics)
Authors: Indah Sari Irma
Published: June 2022

AbstrakKekaguman penulis akan bunga anggrek hitam menggugah keinginan penulis untuk melestarikan tanaman alam Kalimantan ini, dengan cara membuat suatu karya seni dengan konsep batik yang mengangkat tema bunga anggrek hitam. Dengan pembuatan karya ini penulis berharap agar masyarakat memiliki kepedulian dan kesadaran terhadap bunga anggrek hitam dan alam habitatnya. Karya batik ini akan dituangkan di atas tenun Ulap Doyo yang berasal dari serat daun doyo khas Kalimantan Timur. Dalam pembuatan karya seni ini, metode pendekatan yang digunakan adalah pendekatan estetika dan pendekatan empiris, sedangkan metode penciptaan yang digunakan ialah metode penciptaan S.P. Gustami, yakni eksplorasi, perancangan, perwujudan. Karya batik tulis ini menggunakan teknik batik tradisional dengan menggunakan proses canting, teknik pewarnaan sintesis celup tutup, colet dan proses lorodan. Karya ini merupakan karya batik yang dipadukan dengan tenun ulap doyo. Karya yang dihasilkan berupa karya panel yang berfungsi sebagai hiasan interior, dirasakan sangat fleksibel karena bisa untuk hiasan interior di mana saja, selain mudah diapresiasi dan menyampaikan pesan juga dapat mendorong inspirasi ekonomi kreatif kearifan lokal masyarakat setempat.AbstractThe admiration of the authors of black orchid flowers aroused the writer's request to preserve this natural Kalimantan plant, by making artworks with the concept of batik that raised the theme of black orchid flowers. By making this work the author hopes that the community has concern and awareness of the black orchid flower and its natural habitat. This batik work will be poured on the woven Ulap Doyo which comes from doyo leaf fibers typical of East Kalimantan. Making a senior work, the method used is discussing aesthetics and asking for empirical, while the method used is the method that uses S.P. Gustami, namely exploration, design, embodiment. This written batik works using traditional batik techniques using the canting process, the dye synthesis technique, the colet, and the lorodan process. This work is batik work combined with doyo weaving. The work produced by the panel made of interior decoration is accepted to be very flexible because it can only be interior decoration, besides being easily appreciated and conveyed the message can also encourage creative economic inspiration of local wisdom of the local community.