bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of conditional cash transfers (Afya credits incentive) to retain women in the continuum of care during pregnancy, birth and the postnatal period in Kenya: a cluster-randomised trial
Authors: Vanhuyse Fedra , Stirrup Oliver , Odhiambo Aloyce , Palmer Tom , Dickin Sarah , Skordis Jolene , Batura Neha , Haghparast-Bidgoli Hassan , Mwaki Alex , Copas Andrew
Published: January 2022

Objectives

Given high maternal and child mortality rates, we assessed the impact of conditional cash transfers (CCTs) to retain women in the continuum of care (antenatal care (ANC), delivery at facility, postnatal care (PNC) and child immunisation).

Design

We conducted an unblinded 1:1 cluster-randomised controlled trial.

Setting

48 health facilities in Siaya County, Kenya were randomised. The trial ran from May 2017 to December 2019.

Participants

2922 women were recruited to the control and 2522 to the intervention arm.

Interventions

An electronic system recorded attendance and triggered payments to the participant’s mobile for the intervention arm (US$4.5), and phone credit for the control arm (US$0.5). Eligibility criteria were resident in the catchment area and access to a mobile phone.

Primary outcomes

Primary outcomes were any ANC, delivery, any PNC between 4 and 12 months after delivery, childhood immunisation and referral attendance to other facilities for ANC or PNC. Given problems with the electronic system, primary outcomes were obtained from maternal clinic books if participants brought them to data extraction meetings (1257 (50%) of intervention and 1053 (36%) control arm participants). Attendance at referrals to other facilities is not reported because of limited data.

Results

We found a significantly higher proportion of appointments attended for ANC (67% vs 60%, adjusted OR (aOR) 1.90; 95% CI 1.36 to 2.66) and child immunisation (88% vs 85%; aOR 1.74; 95% CI 1.10 to 2.77) in intervention than control arm. No intervention effect was seen considering delivery at the facility (90% vs 92%; aOR 0.58; 95% CI 0.25 to 1.33) and any PNC attendance (82% vs 81%; aOR 1.25; 95% CI 0.74 to 2.10) separately. The pooled OR across all attendance types was 1.64 (1.28 to 2.10).

Conclusions

Demand-side financing incentives, such as CCTs, can improve attendance for appointments. However, attention needs to be paid to the technology, the barriers that remain for delivery at facility and PNC visits and encouraging women to attend ANC visits within the recommended WHO timeframe.

Trial registration

NCT03021070.
Evaluation of compliance with early postbirth follow-up and unnecessary visits to the paediatric emergency department: a prospective observational study at the Lenval Children’s Hospital in Nice
Authors: Tran Antoine , Hérissé Anne-Laure , Isoardo Marion , Valo Petri , Maillotte Anne-Marie , Haas Hervé , Donzeau Dominique , Freyssinet Emma , Pradier Christian , Gentile Stéphanie
Published: January 2022

Objective

To evaluate compliance with the French National Authority for Health’s (Haute Autorité de Santé, HAS) postbirth follow-up recommendations for newborns attending our paediatric emergency department (PED) and identify risk factors associated with non-compliance and unnecessary emergency department utilisation.

Design

Prospective, single centre.

Setting

Fourth biggest PED in France in terms of attendance (CHU-Lenval).

Patients

280 patients of whom 249 were included in the statistical analysis.

Main outcome measures

The primary outcome of this study was the evaluation of compliance of the care pathway for newborns consulting at the PED with respect to the French postbirth follow-up recommendations. Secondary outcome was the assessment of whether the visit to the PED was justified by means of PED reception software and two postconsultation interviews

Results

77.5% (193) of the newborns had non-compliant care pathways and 43% (107) of PED visits were unnecessary. Risk factors associated with a non-compliance regarding the HAS’s postbirth follow-up recommendations were: unnecessary visit to the PED (OR 2.0, 95% CI 1.1 to 3.9), precariousness (OR 2.8, 95% CI 1.4 to 6.2), birth in a public maternity hospital (OR 2.5, 95% CI 1.3 to 4.8) and no information about HAS’s postbirth follow-up recommendations on discharge from maternity ward (OR 11.4, 95% CI 5.8 to 23.3). Risk factors for unnecessary PED visits were: non-compliant care pathway (OR 2.0, 95% CI 1.1 to 3.9) and a first medical visit at a PED (OR 1.8, 95% CI 1.1 to 3.1).

Conclusion

Postbirth follow-up may lead to decrease unnecessary emergency department visits unnecessary emergency department visits.

Trial registration number

The study bears the clinical trial number NCT02863627.
Universal language development screening: comparative performance of two questionnaires
Authors: Wilson Philip , Rush Robert , Charlton Jenna , Gilroy Vicky , McKean Cristina , Law James
Published: January 2022

Background and objective

Low language ability in early childhood is a strong predictor of later psychopathology as well as reduced school readiness, lower educational attainment, employment problems and involvement with the criminal justice system. Assessment of early language development is universally offered in many countries, but there has been little evaluation of assessment tools. We planned to compare the screening performance of two commonly used language assessment instruments.

Methods

A pragmatic diagnostic accuracy study was carried out in five areas of England comparing the performance of two screening tools (Ages and Stages Questionnaire (ASQ) and Sure Start Language Measure (SSLM)) against a reference test (Preschool Language Scale, 5th edition).

Results

Results were available for 357 children aged 23–30 months. The ASQ Communication Scale using optimal cut-off values had a sensitivity of 0.55, a specificity of 0.95 and positive and negative predictive values of 0.53 and 0.95, respectively. The SSLM had corresponding values of 0.83, 0.81, 0.33 and 0.98, respectively. Both screening tools performed relatively poorly in families not using English exclusively in the home.

Conclusion

The very widely used ASQ Communication Scale performs poorly as a language screening tool, missing over one-third of cases of low language ability. The SSLM performed better as a screening tool.
Role of Fcγ receptors in HER2-targeted breast cancer therapy
Authors: Musolino Antonino , Gradishar William J , Rugo Hope S , Nordstrom Jeffrey L , Rock Edwin P , Arnaldez Fernanda , Pegram Mark D
Published: January 2022

Several therapeutic monoclonal antibodies (mAbs), including those targeting epidermal growth factor receptor, human epidermal growth factor receptor 2 (HER2), and CD20, mediate fragment crystallizable gamma receptor (FcγR)–dependent activities as part of their mechanism of action. These activities include induction of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), which are innate immune mechanisms of cancer cell elimination. FcγRs are distinguished by their affinity for the Fc fragment, cell distribution, and type of immune response they induce. Activating FcγRIIIa (CD16A) on natural killer cells plays a crucial role in mediating ADCC, and activating FcγRIIa (CD32A) and FcγRIIIa on macrophages are important for mediating ADCP. Polymorphisms in FcγRIIIa and FcγRIIa generate variants that bind to the Fc portion of antibodies with different affinities. This results in differential FcγR-mediated activities associated with differential therapeutic outcomes across multiple clinical settings, from early stage to metastatic disease, in patients with HER2+ breast cancer treated with the anti-HER2 mAb trastuzumab. Trastuzumab has, nonetheless, revolutionized HER2+ breast cancer treatment, and several HER2-directed mAbs have been developed using Fc glyco-engineering or Fc protein-engineering to enhance FcγR-mediated functions. An example of an approved anti-HER2 Fc-engineered chimeric mAb is margetuximab, which targets the same epitope as trastuzumab, but features five amino acid substitutions in the IgG 1 Fc domain that were deliberately introduced to increase binding to activating FcγRIIIa and decrease binding to inhibitory FcγRIIb (CD32B). Margetuximab enhances Fc-dependent ADCC in vitro more potently than the combination of pertuzumab (another approved mAb directed against an alternate HER2 epitope) and trastuzumab. Margetuximab administration also enhances HER2-specific B cell and T cell–mediated responses ex vivo in samples from patients treated with prior lines of HER2 antibody-based therapies. Stemming from these observations, a worthwhile future goal in the treatment of HER2+ breast cancer is to promote combinatorial approaches that better eradicate HER2+ cancer cells via enhanced immunological mechanisms.
Intratumor expanded T cell clones can be non-sentinel lymph node derived in breast cancer revealed by single-cell immune profiling
Authors: Jiao Shiping , Xiong Qing , Yan Meisi , Zhan Xiaolu , Yang Zhenhuang , Peng Cheng , Sun Beicheng , Pang Da , Liu Tong
Published: January 2022

Background

Sentinel lymph nodes (LNs) are regarded as key immune surveillance sites in cancer wherein mature dendritic cells present tumor-derived antigens to prime and activate T cells, which then migrate to the tumor site. However, it is unclear whether the tumor-specific T cells can be elicited within the tumor independent of the sentinel LNs.

Methods

We performed an integrative analysis of gene expression profiles of 65,285 cells and T cell receptor sequences of 15,831 T cells from 5 paired primary breast tumors and sentinel LNs to identify where clonal T cells come from and the characteristics of those clonal T cells.

Results

The proportion of clonal T cells was higher in the primary tumors compared with the sentinel LNs, whereas all expanded clones identified in the sentinel LN were also present in the primary tumors. In contrast, 10.91% of the expanded clones in the primary tumors were not found in the sentinel LNs. These novel intratumoral T cell clones were characterized by high tissues retention capacity (CXCR6 +ITGAE+) and a distinct coinhibitory pattern (CD39 +NKG2A+) compared with the expanded T cell clones common to both sites. Furthermore, multiplex immunofluorescence imaging showed the presence of tertiary lymphoid structures (TLS) in the primary breast tumors wherein the activated cytolytic T cells were concentrated, indicating its possible role in eliciting non-sentinel LN-derived T cell clones.

Conclusions

Our study revealed expanded intratumor non-sentinel LN derived T cell clones located in the TLS, which points to the need for exploring the role of TLS in antitumor immunity.
Frontline thrombectomy strategy and outcome in acute basilar artery occlusion
Authors: Abdelrady Mohamed , Ognard Julien , Cagnazzo Federico , Derraz Imad , Lefevre Pierre-Henri , Riquelme Carlos , Gascou Gregory , Arquizan Caroline , Dargazanli Cyril , Cheddad El Aouni Mourad , Ben Salem Douraied , Mourand Isabelle , Costalat Vincent , Gentric Jean Christophe
Published: January 2022

Background

Novel thrombectomy strategies emanate expeditiously day-by-day counting on access system, clot retriever device, proximity to and integration with the thrombus, and microcatheter disengagement. Nonetheless, the relationship between native thrombectomy strategies and revascularization success remains to be evaluated in basilar artery occlusion (BAO).

Purpose

To compare the safety and efficacy profile of key frontline thrombectomy strategies in BAO.

Methods

Retrospective analyses of prospectively maintained stroke registries at two comprehensive stroke centers were performed between January 2015 and December 2019. Patients with BAO selected after MR imaging were categorized into three groups based on the frontline thrombectomy strategy (contact aspiration (CA), stent retriever (SR), or combined (SR+CA)). Patients who experienced failure of clot retrieval followed by an interchanging strategy were categorized as a fourth (switch) group. Clinicoradiological features and procedural variables were compared. The primary outcome measure was the rate of complete revascularization (modified Thrombolysis in Cerebral Infarction (mTICI) grade 2c–3). Favorable outcome was defined as a 90 day modified Rankin Scale score of 0–2.

Results

Of 1823 patients, we included 128 (33 underwent CA, 35 SR, 35 SR +CA, and 25 switch techniques). Complete revascularization was achieved in 83/140 (59%) primarily analyzed patients. SR +CA was associated with higher odds of complete revascularization (adjusted OR 3.04, 95% CI 1.077 to 8.593, p=0.04) which was an independent predictor of favorable outcome (adjusted OR 2.73. 95% CI 1.152 to 6.458, p=0.02). No significant differences were observed for symptomatic intracranial hemorrhage, functional outcome, or mortality rate.

Conclusion

Among BAO patients, the combined technique effectively contributed to complete revascularization that showed a 90 day favorable outcome with an equivalent complication rate after thrombectomy.
Environmental tobacco smoke and carotid intima–media thickness in healthy children and adolescents: a systematic review
Authors: Shu Dingbo , Chen Feng , Zhang Chuan , Guo Wentong , Dai Siyu
Published: January 2022

Thicker carotid intima–media thickness (CIMT) has been a valid predictor for atherosclerosis development. A significant association between environmental tobacco smoke (ETS) and thickening of CIMT has been demonstrated in adults, whereas such association has scarcely been reviewed in paediatric population. The dominate electronic databases, including MEDLINE (Ovid), PubMed, Embase, CINAHL, Web of Science, Scopus, were searched from inception. Reference lists of retrieved articles were further scanned as to avoid any missing literatures. Newcastle-Ottawa scale was used to assess the quality of the included studies. Qualitative synthesis analyses were performed on the selected studies. 331 articles were retrieved, and 4 were finally selected. All four studies investigated the association between postnatal ETS and CIMT in children, and three of them reported a statistically significant positive association. Three studies investigated the association between prenatal maternal ETS and CIMT, and one of the three found a positive association. Two studies explored the association between postnatal maternal ETS and CIMT, one reported a positive association. Two studies used serum cotinine measurement to quantify ETS and demonstrated potential dose-response relationship with CIMT. ETS exposure may play an independent role in the development of cardiovascular risks in healthy children and adolescents. In the consideration of the great burden of respiratory and cardiovascular diseases, there is an urgent need of effective surveillance for paediatric population’s ETS exposure to reduce smoke exposure.
Colchicine for symptomatic coronary artery disease after percutaneous coronary intervention
Authors: Aw Kah Long , Koh Amanda , Lee Han Lin , Kudzinskas Aurimas , De Palma Rodney
Published: January 2022

Background

Percutaneous coronary intervention (PCI), the preferred coronary reperfusion strategy, induces endothelial trauma which may mount an inflammatory response. This has been shown to increase the likelihood of further major adverse cardiovascular events (MACE). Colchicine, a cheap and widely used anti-inflammatory has shown promise in improving cardiovascular outcomes. We aimed to perform a systematic review and meta-analysis to study the effects of colchicine in patients with symptomatic coronary artery disease (CAD) who have undergone PCI.

Method

We systematically reviewed and meta-analysed 7 randomised controlled trials including a total of 6660 patients (colchicine group: 3347, control group: 3313; mean age=60.9±10). Six studies included participants who had a ≤13.5-day history of acute coronary syndrome (ACS). One study included patients with both ACS and chronic coronary syndrome. The follow-up of studies ranged from 3 days to 22.6 months.

Results

The use of colchicine in patients who underwent PCI significantly reduced MACE outcomes (risk ratio 0.73 (95% CI 0.61 to 0.87); p=0.0003) with minimal heterogeneity across the analysis (I2=6%; P for Cochran Q=0.38). These results were driven mainly by the reduction in repeat vessel revascularisation, stroke and stent thrombosis. The number needed to treat to prevent one occurrence of MACE was 41.

Conclusion

Colchicine significantly reduced the risk of MACE in patients with CAD who underwent PCI, mostly in the reduction of repeat vessel revascularisation, stroke and stent thrombosis. The efficacy of colchicine should be further studied by distinguishing its use alongside different stent types and dosing regimens.

PROSPERO registration number

CRD42021245699.
Neuraxial and general anesthesia for outpatient total joint arthroplasty result in similarly low rates of major perioperative complications: a multicentered cohort study
Authors: Yap Edward , Wei Julia , Webb Christopher , Ng Kevin , Behrends Matthias
Published: January 2022

Background

Neuraxial anesthesia when compared with general anesthesia has shown to improve outcomes following lower extremity total joint arthroplasty. It is unclear whether these benefits are present in outpatient surgery given the selection of healthier patients.

Objective

To compare the effects of neuraxial versus general anesthesia on outcomes following ambulatory hip and knee arthroplasty.

Methods

Multicentered retrospective cohort study in ambulatory hip or knee arthroplasty patients between January 2017 and December 2019. Primary endpoint examined 30-day major postoperative complications (mortality, myocardial infarction, deep venous thromboembolism, pulmonary embolism, stroke, and acute renal failure).

Results

Of 11 523 eligible patients identified, 10 003 received neuraxial anesthesia, while 1520 received general anesthesia. 30-day major complications did not differ between neuraxial anesthesia and general anesthesia groups (1.8% vs 2.3%; aOR=0.85, CI: 0.56 to 1.27, p=0.39). There was no difference in 30-day minor complications (surgical site infection, pneumonia, urinary tract infection; 3.3% vs 4.1%; aOR=0.83, CI: 0.62 to 1.14, p=0.23). The neuraxial group demonstrated reduced pain and analgesia requirements and had less postoperative nausea and vomiting (PONV). Median recovery room length of stay was shorter by 52 min in the general anesthesia group, but these patients were more likely to fail same day discharge (33% vs 23.4%; p<0.01).

Conclusion

Anesthesia type was not associated with an increased risk for complications. However, neuraxial anesthesia improved outcomes that predict readiness for discharge: patients had less pain, required less opioids, and had a lower incidence of PONV, thus improving the rate of same day discharge.

Trial registration number

NCT04203732.
High platelet distribution width can independently predict testicular survival in testicular torsion among patients with steady-state sickle cell anemia
Authors: Adawi Essa A , Ghanem Mazen Ahmed , Ghanem Ahmed Mazen , Safan Manal A , Elsayed Mohamed G , Aqeel Mohammed A
Published: January 2022

Objective

This study aimed to evaluate the predictive value of platelet volume indices (PVI), such as mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT), as prognostic indicators of testicular viability in torsion patients with steady-state sickle cell anemia (SCA) who underwent surgical exploration.

Methods

Forty-eight patients with SCA with testicular torsion and 46 male control subjects were enrolled in the study. All patients underwent scrotal color Doppler ultrasonography before surgery, and PVI (MPV, PDW, and PCT) values were measured in all participants. Symptom duration and testicular volume were also recorded.

Results

The testicular salvage rate in patients with SCA was 73% after surgery. Analyses showed that MPV, PDW, and PCT values were significantly higher in torsed SCA as compared with controls (p<0.05). Orchiectomy in patients with SCA showed significantly higher MPV, PDW, and PCT values than the orchiopexy group (p<0.05). The MPV values of orchiectomy patients showed a higher significant cut-off of ≥11.5 fL, which is higher than in torsed patients without SCA, as an indicator of testis survival. PDW also demonstrated a higher significant cut-off of ≥12.7 fL for detorsion outcomes in patients with SCA. Symptom duration of less than 7 hours was also significantly correlated with orchiopexy (p≤0.001). Univariate analysis showed that higher MPV, increased PDW, and symptom duration were indicative of the outcome of testicular detorsion in SCA. Multivariable analysis showed that increased PDW and symptom duration are prognostic parameters for testicular viability in SCA.

Conclusion

Increased PDW and symptom duration can be used as parameters for predicting testicular detorsion outcomes in patients with steady-state SCA.
Metformin exerts anti-tumor effects via Sonic hedgehog signaling pathway by targeting AMPK in HepG2 cells
Authors: Hu Ang , Hu Zeming , Ye Jianming , Liu Yuwen , Lai Zhonghong , Zhang Mi , Ji Weichao , Huang Lili , Zou Haohong , Chen Bin , Zhong Jianing
Published: January 2022

Metformin, a traditional first-line pharmacological treatment for type 2 diabetes, has recently been shown to have anti-cancer effects on hepatocellular carcinoma (HCC). However, the molecular mechanism underlying the anti-tumor activity of metformin remains unclear. The Sonic hedgehog (Shh) signaling pathway is closely associated with the initiation and progression of HCC. Therefore, the aim of the current study was to investigate the effects of metformin on the biological behavior of HCC and the underlying functional mechanism of metformin in the Shh pathway. HCC was induced in HepG2 cells using recombinant human Shh (rhShh). The effects of metformin on proliferation and metastasis were evaluated using in vitro proliferation, wound healing, and invasion assays. The mRNA and protein expression levels of proteins related to the Shh pathway were measured using western blotting, quantitative PCR, and immunofluorescence staining. Metformin inhibited rhShh-induced proliferation and metastasis. Furthermore, metformin decreased the mRNA and protein expression of Shh pathway components, including Shh, Ptch, Smo, and Gli-1. Silencing of AMPK in the presence of metformin revealed that metformin exerted its inhibitory effects via AMPK. Our findings demonstrate that metformin suppresses the migration and invasion of HepG2 cells via AMPK-mediated inhibition of the Shh pathway.
Linking functional diversity to ecological indicators: a tool to predict anthropogenic effects on ecosystem functioning
Authors: Bonilla-Valencia Leticia , Castillo-Agüero Silvia , Zavala-Hurtado José Alejandro , Espinosa García Francisco J. , Lindig-Cisneros Roberto , Martínez-Orea Yuriana
Published: January 2022

Functional diversity is related to the maintenance of processes and functions in ecosystems. However, there is a lack of a conceptual framework that highlights the application of functional diversity as an ecological indicator. Therefore, we present a new initiative for motivating the development of ecological indicators based on functional diversity. We are interested in showing the challenges and solutions associated with these indicators. We integrated species assemblage theories and literature reviews. We considered plant traits related to ecosystem processes and functions (specific leaf area, leaf dry matter content, wood density, phenology, and seed mass) to show the application of a selection of functional diversity metrics that can be used as ecological indicators (i.e., community weighted-mean, functional divergence, functional richness and functional evenness). We caution that functional diversity as an ecological indicator can be misinterpreted if species composition is unknown. Functional diversity values can be over-represented by weed species (species established in disturbed sites) and do not maintain original processes and functions in ecosystems. Therefore, we searched for evidence to demonstrate that weed species are ecological indicators of functional diversity changes. We found support for two hypotheses that explain the effect of weed species on ecosystem function: functional homogenization, and functional transformation. Likewise, we showed the application of some tools that can help study anthropogenic effects on functional indicators. This perspective shows that the paradigm of addressing the effects of disturbances on ecosystem processes by using functional diversity as an ecological indicator can improve environmental evaluation, particularly in areas affected by human activities.
Weakly Supervised Spatial Deep Learning for Earth Image Segmentation Based on Imperfect Polyline Labels
Authors: Jiang Zhe , He Wenchong , Kirby Marcus Stephen , Sainju Arpan Man , Wang Shaowen , Stanislawski Lawrence V. , Shavers Ethan J. , Usery E. Lynn
Published: January 2022

In recent years, deep learning has achieved tremendous success in image segmentation for computer vision applications. The performance of these models heavily relies on the availability of large-scale high-quality training labels (e.g., PASCAL VOC 2012). Unfortunately, such large-scale high-quality training data are often unavailable in many real-world spatial or spatiotemporal problems in earth science and remote sensing (e.g., mapping the nationwide river streams for water resource management). Although extensive efforts have been made to reduce the reliance on labeled data (e.g., semi-supervised or unsupervised learning, few-shot learning), the complex nature of geographic data such as spatial heterogeneity still requires sufficient training labels when transferring a pre-trained model from one region to another. On the other hand, it is often much easier to collect lower-quality training labels with imperfect alignment with earth imagery pixels (e.g., through interpreting coarse imagery by non-expert volunteers). However, directly training a deep neural network on imperfect labels with geometric annotation errors could significantly impact model performance. Existing research that overcomes imperfect training labels either focuses on errors in label class semantics or characterizes label location errors at the pixel level. These methods do not fully incorporate the geometric properties of label location errors in the vector representation. To fill the gap, this article proposes a weakly supervised learning framework to simultaneously update deep learning model parameters and infer hidden true vector label locations. Specifically, we model label location errors in the vector representation to partially reserve geometric properties (e.g., spatial contiguity within line segments). Evaluations on real-world datasets in the National Hydrography Dataset (NHD) refinement application illustrate that the proposed framework outperforms baseline methods in classification accuracy.
DeepRoute+: Modeling Couriers’ Spatial-temporal Behaviors and Decision Preferences for Package Pick-up Route Prediction
Authors: Wen Haomin , Lin Youfang , Wan Huaiyu , Guo Shengnan , Wu Fan , Wu Lixia , Song Chao , Xu Yinghui
Published: January 2022

Over 10 billion packages are picked up every day in China. A fundamental task raised in the emerging intelligent logistics systems is the couriers’ package pick-up route prediction, which is beneficial for package dispatching, arrival-time estimation and overdue-risk evaluation, by leveraging the predicted routes to improve those downstream tasks. In the package pick-up scene, the decision-making of a courier is affected by strict spatial-temporal constraints (e.g., package location, promised pick-up time, current time, and courier’s current location). Furthermore, couriers have different decision preferences on various factors (e.g., time factor, distance factor, and balance of both), based on their own perception of the environments and work experience. In this article, we propose a novel model, named DeepRoute+, to predict couriers’ future package pick-up routes according to the couriers’ decision experience and preference learned from the historical behaviors. Specifically, DeepRoute+ consists of three layers: (1) The representation layer produces experience- and preference-aware representations for the unpicked-up packages, in which a decision preference module can dynamically adjust the importance of factors that affects the courier’s decision under the current situation. (2) The transformer encoder layer encodes the representations of packages while considering the spatial-temporal correlations among them. (3) The attention-based decoder layer uses the attention mechanism to generate the whole pick-up route recurrently. Experiments on a real-world logistics dataset demonstrate the state-of-the-art performance of our model.
Motor Variability in Complex Gesture Learning: Effects of Movement Sonification and Musical Background
Authors: Liu Wanyu , Magalhaes Michelle Agnes , Mackay Wendy E. , Beaudouin-Lafon Michel , Bevilacqua Frédéric
Published: January 2022

With the increasing interest in movement sonification and expressive gesture-based interaction, it is important to understand which factors contribute to movement learning and how. We explore the effects of movement sonification and users’ musical background on motor variability in complex gesture learning. We contribute an empirical study in which musicians and non-musicians learn two gesture sequences over three days, with and without movement sonification. Results show the interlaced interaction effects of these factors and how they unfold in the three-day learning process. For gesture 1, which is fast and dynamic with a direct “action-sound” sonification, movement sonification induces higher variability for both musicians and non-musicians on day 1. While musicians reduce this variability to a similar level as no auditory feedback condition on day 2 and day 3, non-musicians remain to have significantly higher variability. Across three days, musicians also have significantly lower variability than non-musicians. For gesture 2, which is slow and smooth with an “action-music” metaphor, there are virtually no effects. Based on these findings, we recommend future studies to take into account participants’ musical background, consider longitudinal study to examine these effects on complex gestures, and use awareness when interpreting the results given a specific design of gesture and sound.
Make More Connections: Urban Traffic Flow Forecasting with Spatiotemporal Adaptive Gated Graph Convolution Network
Authors: Lu Bin , Gan Xiaoying , Jin Haiming , Fu Luoyi , Wang Xinbing , Zhang Haisong
Published: January 2022

Urban traffic flow forecasting is a critical issue in intelligent transportation systems. Due to the complexity and uncertainty of urban road conditions, how to capture the dynamic spatiotemporal correlation and make accurate predictions is very challenging. In most of existing works, urban road network is often modeled as a fixed graph based on local proximity. However, such modeling is not sufficient to describe the dynamics of the road network and capture the global contextual information. In this paper, we consider constructing the road network as a dynamic weighted graph through attention mechanism. Furthermore, we propose to seek both spatial neighbors and semantic neighbors to make more connections between road nodes. We propose a novel

Spatiotemporal Adaptive Gated Graph Convolution Network

(
STAG-GCN
) to predict traffic conditions for several time steps ahead. STAG-GCN mainly consists of two major components: (1) multivariate self-attention
Temporal Convolution Network
(
TCN
) is utilized to capture local and long-range temporal dependencies across recent, daily-periodic and weekly-periodic observations; (2) mix-hop AG-GCN extracts selective spatial and semantic dependencies within multi-layer stacking through adaptive graph gating mechanism and mix-hop propagation mechanism. The output of different components are weighted fused to generate the final prediction results. Extensive experiments on two real-world large scale urban traffic dataset have verified the effectiveness, and the multi-step forecasting performance of our proposed models outperforms the state-of-the-art baselines.
The Lord of the Ring Road: A Review and Evaluation of Autonomous Control Policies for Traffic in a Ring Road
Authors: Chou Fang-Chieh , Bagabaldo Alben Rome , Bayen Alexandre M.
Published: January 2022

This study focuses on the comprehensive investigation of stop-and-go waves appearing in closed-circuit ring road traffic wherein we evaluate various longitudinal dynamical models for vehicles. It is known that the behavior of human-driven vehicles, with other traffic elements such as density held constant, could stimulate stop-and-go waves, which do not dissipate on the circuit ring road. Stop-and-go waves can be dissipated by adding automated vehicles (AVs) to the ring. Thorough investigations of the performance of AV longitudinal control algorithms were carried out in Flow, which is an integrated platform for reinforcement learning on traffic control. Ten AV algorithms presented in the literature are evaluated. For each AV algorithm, experiments are carried out by varying distributions and penetration rates of AVs. Two different distributions of AVs are studied. For the first distribution scenario, AVs are placed consecutively. Penetration rates are varied from 1 AV (5%) to all AVs (100%). For the second distribution scenario, AVs are placed with even distribution of human-driven vehicles in between any two AVs. In this scenario, penetration rates are varied from 2 AVs (10%) to 11 AVs (50%). Multiple runs (10 runs) are simulated to average out the randomness in the results. From more than 3,000 simulation experiments, we investigated how AV algorithms perform differently with varying distributions and penetration rates while all AV algorithms remained fixed under all distributions and penetration rates. Time to stabilize, maximum headway, vehicle miles traveled, and fuel economy are used to evaluate their performance. Using these metrics, we find that the traffic condition improvement is not necessarily dependent on the distribution for most of the AV controllers, particularly when no cooperation among AVs is considered. Traffic condition is generally improved with a higher AV penetration rate with only one of the AV algorithms showing a contrary trend. Among all AV algorithms in this study, the reinforcement learning controller shows the most consistent improvement under all distributions and penetration rates.
Conversation-Based Assessments: Real-Time Assessment and Feedback
Authors: Yildirim-Erbasli Seyma N. , Bulut Okan
Published: January 2022

In recent years, substantial progress has been made in the application of technology for learning environments to support interaction and learning. However, current digital assessments still need to be modified to measure student learning in more engaging and effective ways. Conversation-based assessment (CBA) advances the conventional digital assessments by creating a conversational environment between test-takers and agents where each test-taker receives feedback for their correct responses and hints or follow-up questions for their incorrect responses through a natural conversation. This work provides a summary of CBAs by discussing their advantages and differences from conventional digital assessments.
Nanomechanics of Blood Clot and Thrombus Formation
Authors: Domingues Marco M. , Carvalho Filomena A. , Santos Nuno C.
Published: January 2022

Mechanical properties have been extensively studied in pure elastic or viscous materials; however, most biomaterials possess both physical properties in a viscoelastic component. How the biomechanics of a fibrin clot is related to its composition and the microenvironment where it is formed is not yet fully understood. This review gives an outline of the building mechanisms for blood clot mechanical properties and how they relate to clot function. The formation of a blood clot in health conditions or the formation of a dangerous thrombus go beyond the mere polymerization of fibrinogen into a fibrin network. The complex composition and localization of in vivo fibrin clots demonstrate the interplay between fibrin and/or fibrinogen and blood cells. The study of these protein–cell interactions and clot mechanical properties may represent new methods for the evaluation of cardiovascular diseases (the leading cause of death worldwide), creating new possibilities for clinical diagnosis, prognosis, and therapy.
FLEET Velocimetry for Aerodynamics
Authors: Danehy Paul M. , Burns Ross A. , Reese Daniel T. , Retter Jonathan E. , Kearney Sean P.
Published: January 2022

Long-lasting emission from femtosecond excitation of nitrogen-based flows shows promise as a useful mechanism for a molecular tagging velocimetry instrument. The technique, known as femtosecond laser electronic excitation tagging (FLEET), was invented at Princeton a decade ago and has quickly been adopted and used in a variety of high-speed ground test flow facilities. The short temporal scales offered by femtosecond amplifiers permit nonresonant multiphoton excitation, dissociation, and weak ionization of a gaseous medium near the beam's focus without the generation of a laser spark observed with nanosecond systems. Gated, intensified imaging of the resulting emission enables the tracking of tagged molecules, thereby measuring one to three components of velocity. Effects of local heating and acoustic disturbances can be mitigated with the selection of a shorter-wavelength excitation source. This review surveys the development of FLEET over the decade since its inception, as it has been implemented in several test facilities to make accurate, precise, and seedless velocimetry measurements for studying complex high-speed flows.
Compositional, Structural, and Kinetic Aspects of Lipid Digestion and Bioavailability: In Vitro, In Vivo, and Modeling Approaches
Authors: Marze Sébastien
Published: January 2022

Lipid digestion and bioavailability are usually investigated separately, using different approaches (in vitro, modeling, in vivo). However, a few inclusive studies show that their kinetics are closely linked. Lipid bioavailability kinetics is likely involved in the development and evolution of several diseases, so lipid digestion kinetics could be involved as well and can be modulated by food design or combination. To illustrate this possibility, the compositional and structural aspects of lipid digestion kinetics, as investigated using in vitro and modeling approaches, are presented first. Then, in vivo and mixed approaches enabling the study of both kinetics are reviewed and discussed. Finally, disparate modeling approaches are introduced, and a unifying modeling scheme is proposed, opening new perspectives for understanding the role and interactions of various factors (chemical, physical, and biological) involved in lipid metabolism.
Modelling the Impedance Response of Graded LiFePO4 Cathodes for Li-Ion Batteries
Authors: Drummond R. , Cheng C. , Grant P. S. , Duncan S. R.
Published: January 2022

Graded electrodes for Li-ion batteries aim to exploit controlled variations in local electrode microstructure to improve overall battery performance, including reduced degradation rates and increased capacity at high discharge rates. However, the mechanisms by which grading might deliver performance benefit, and under what conditions, are not yet fully understood. A Li-ion battery electrochemical model (a modified Doyle-Fuller-Newman type model capable of generating impedance functions) is developed in which local microstructural changes are captured in order to understand why and when graded electrodes can offer performance benefits. Model predictions are evaluated against experimental electrochemical impedance data obtained from electrodes with micro-scale, controlled variations in microstructure. A region locally enriched with carbon at the electrode/current collector interface is shown to significantly reduce the overpotential distribution across the thickness of a LiFePO4-based Li-ion battery cathode, resulting in a lower charge transfer resistance and impedance. The insights gained from the LiFePO4-based electrodes are generalised to wider design principles for both uniform and graded Li-ion battery electrodes.
(Invited) New Carbon Electrodes for Neurochemistry
Authors: Venton B. Jill , Cao Qun , Puthongkham Pumidech
Published: January 2022

Carbon-fiber microelectrodes are the standard for neurochemical measurements, but improvements can be made for both sensitivity and spatial resolution. In this talk, I will cover how principles of thin layer cell electrochemistry are driving the design of new carbon electrodes. Specifically, electrodes that have roughness on the micron scale or cavities that trap dopamine are useful for enhancing the sensitivity and selectivity of electrodes. Three examples will be discussed, CNT yarn electrodes, cavity carbon nanopipettes, and 3D printed electrodes. These examples show how new technology, combined with a fundamental understanding of electrochemistry, is pushing development of better electrodes for neurochemistry.
Unbalanced Big Data-Compatible Cloud Storage Method Based on Redundancy Elimination Technology
Authors: Yu Tingting
Published: January 2022

In order to meet the requirements of users in terms of speed, capacity, storage efficiency, and security, with the goal of improving data redundancy and reducing data storage space, an unbalanced big data compatible cloud storage method based on redundancy elimination technology is proposed. A new big data acquisition platform is designed based on Hadoop and NoSQL technologies. Through this platform, efficient unbalanced data acquisition is realized. The collected data are classified and processed by classifier. The classified unbalanced big data are compressed by Huffman algorithm, and the data security is improved by data encryption. Based on the data processing results, the big data redundancy processing is carried out by using the data deduplication algorithm. The cloud platform is designed to store redundant data in the cloud. The results show that the method in this paper has high data deduplication rate and data deduplication speed rate and low data storage space and effectively reduces the burden of data storage.
Serum Antithyroglobulin Antibody Levels Are Associated with Diabetic Retinopathy among Euthyroid Type 2 Diabetes Patients: A Hospital-Based, Retrospective Study
Authors: Gao Xiaotong , Wang Xichang , Zhong Yifan , Liu Lei , Teng Weiping , Shan Zhongyan
Published: January 2022

Background. Previous studies have revealed that the variation of thyroid indicators may be associated with the risk of diabetic retinopathy (DR) among euthyroid type 2 diabetes (T2D) patients. But the specific conclusions are currently inconsistent. Methods. This is a hospital-based retrospective survey. We recruited 1,145 euthyroid T2D patients and checked the thyroid function and fundus photographs. The modified Airlie House classification system was used to categorize the stages of DR. The association between thyroid indicators and different stages of DR was analyzed. Results. We divided free triiodothyronine (FT3) into tertiles and found that the prevalence of mild nonproliferative DR (NPDR) was significantly higher in T2, compared with T1 (32.0% vs. 25.2%,

p
<
0.05

). When FT3 was within the level of T2, FT3 could be an independent risk factor for mild NPDR (OR 1.426, 95% CI (1.031, 1.971),

p
<
0.05

). In addition, the prevalence of severe NPDR and proliferative DR (PDR) was significantly higher in thyroglobulin antibody (TgAb) positive group (8.8% vs. 4.1%,

p
<
0.05

) and vice versa (33.3% vs. 18.4%,

p
<
0.05

). TgAb positivity was also an independent risk factor for severe NPDR and PDR (OR 2.212, 95% CI (1.244, 3.934),

p
<
0.05

). Conclusions. We hardly observed a significant change in DR risk with the elevation or reduction of serum TSH or thyroid hormone within the reference interval. Although the slightly elevated FT3 may be associated to mild NPDR, the extensibility of this result remains to be seen. For T2D patients with euthyroid function, there may be a significant correlation between serum TgAb positivity and severe NPDR and PDR.
A Randomized Controlled Clinical Trial of Lifestyle Intervention and Pioglitazone for Normalization of Glucose Status in Chinese with Prediabetes
Authors: Luo Yingying , Wang Hongyuan , Zhou Xianghai , Chang Cuiqing , Chen Wei , Guo Xiaohui , Yang Jinkui , Ji Linong , Paul Sanjoy K.
Published: January 2022

Aims. Prediabetes has been proved as an important risk factor of both diabetes and cardiovascular disease (CVD). Previous studies have shown that both lifestyle intervention and pioglitazone may delay the development of diabetes in patients with prediabetes. However, no study has ever explored whether these interventions could revert prediabetes to normal glycemic status as the primary outcome. Interventions that may revert prediabetes back to normal glucose status would be of great clinical importance. Materials and Methods. We conducted a randomized, multicenter,

2
×
2

factorial designed study to examine whether intensive lifestyle intervention and/or pioglitazone could revert prediabetes to normal glucose tolerance. The participants were followed up for three years unless they reverted to normal glucose state or developed diabetes at the annual oral glucose tolerance test (OGTT). Reversion to normal glucose tolerance was confirmed on the basis of the results of OGTT. Results. In our study, 1945 eligible patients were ultimately randomized into four groups. In this three-year follow-up study, overall, 60.0%, 50.3%, 56.6% and 65.1% reverted back to normoglycemic state over 3 years of follow-up in the conventional lifestyle intervention plus placebo, intensive lifestyle intervention plus placebo, conventional lifestyle intervention plus pioglitazone, and intensive lifestyle intervention plus pioglitazone groups, respectively. Compared to the conventional lifestyle intervention plus placebo group, all the other three groups did not show any significant benefit in terms of reverting back to normoglycemic state. Conclusion. In our study, for patients with prediabetes, neither intensive lifestyle intervention nor pioglitazone had led to a higher reversion rate to normal glucose state. Trail registration.http://www.chictr.org.cn: ChiCTR-PRC-06000005.
A Case of Metastatic CNS Melanoma of Unknown Primary Presenting with Seizures
Authors: Nguyen Viva , Aboulenain Samar , Mohammed Shawn , Perez Parra Sahyli
Published: January 2022

Seizures are a common occurrence. The goal of evaluating a seizure is to identify the etiology and to determine the likelihood of recurrence as well as guide management. We present a unique presentation of a 47-year-old female that presented with late onset seizures admitted due to status epilepticus. Brain magnetic resonance indicated diffuse supratentorial hemorrhagic lesions. Neurological workup including brain vessel imaging, CT chest, abdomen, and pelvis as well as CSF and serological workup for vasculitis failed to demonstrate the cause of her brain lesions. Ultimately, a brain biopsy showed metastatic melanoma of unknown primary origin.
Pegylated Interferon Alpha for Chronic Hepatitis B Virus Infection
Authors: Vasconcelos Joana , Domingos João , Bastos Lia , Baptista Teresa , Mansinho Kamal
Published: January 2022

Chronic hepatitis B (CHB) is a potentially life-threatening and prevalent disease worldwide. Far from attaining the ultimate treatment goal, hepatitis B virus (HBV) infection eradication, the two current therapeutic options aim to prevent progression to end-stage liver disease, maintaining long-term suppression of HBV replication. Pegylated interferon-α (PEG-INFα) is often poorly tolerated and disregarded considering the orally administered nucleos(t)ide analogues. However, PEG-INFα may achieve similar treatment endpoints with a finite course of treatment. We report a case of PEG-INFα-treated CHB that attained sustained off-treatment virological response with only 16 weeks of treatment, with loss of both HBeAg and HBsAg (this latter the optimal treatment endpoint).