bluuebunny/crossref_metadata_2025 huggingface dataset:
Kebijakan Program Pengembangan Koperasi, Usaha Mikro Kecil Menengah Di Kabupaten Aceh Tengah
Authors: Nuswantoro Patriandi , Jaya Taniro
Published: December 2021

Latar belakang: Jumlah koperasi dan kelompok usaha mikro kecil menengah dan daya serap tenaga kerja yang cukup besar ternyata perkembangannya masih jauh dari yang diharapkan.
Tujuan penelitian: Untuk mempercepat pemerataan pembangunan serta mengurangi kemiskinan dan pengangguran.
Metode penelitian: Desain penelitian yang digunakan adalah pendekatan kualitatif. Peneliti merupakan key instrument dalam penelitian kualitatif. Penelitian menggunakan purposive sampling.
Hasil penelitian: Besaran dan tujuan kebijakan tersebut telah dilaksanakan dengan tingkat keberhasilan banyak program kerjasama yang bergerak di bidang usaha perdagangan kopi yang telah diekspor ke beberapa negara. Sumber daya manusia yang terlibat dalam pengembangan UMKM relatif sudah cukup. Karakteristik lembaga pelaksana dapat dibagi menjadi pembina, penyuluh dan pendamping. Sikap para pelaksana sangat antusias dan berusaha sungguh-sungguh, dan keberadaannya direspon positif oleh pengurus koperasi dan UMKM. Komunikasi antar organisasi yang bekerja sama dengan mitra telah melakukan sedikit upaya pengembangan KUMKM dan sangat terjalin dengan baik. Lingkungan ekonomi, sosial dan politik telah berkembang sangat baik, seiring dengan meningkatnya tingkat penerimaan masyarakat dengan indikasi jual harga kopi yang cenderung meningkat dan stabil, baik di pasar lokal maupun di pasar internasional.
Kesimpulan: Tingkat keberhasilan program di lihat dari banyaknya koperasi-koperasi terutama yang bergerak dibidang usaha perdagangan kopi telah dapat melakukan ekspor ke beberapa negara. Faktor pendorong implementasi kebijakan pengembangan koperasi, usaha mikro kecil menengah di Kabupaten Aceh Tengah adalah respon positif masyarakat, adanya kesadaran publik menerima kebijakan dan sikap publik menerima dan melaksanakan kebijakan. Faktor kendala implementasi kebijakan pengembangan koperasi, usaha mikro kecil menengah di Kabupaten Aceh Tengah adalah minimnya anggaran dan fasilitas  dan persepsi yang salah di masyarakat
Economic Student Scientific Publication Model Exploration Factor Analysis (EFA) Approach
Authors: Piter Nizu Kekry Boy , Shinta Komang Saraswati , Yare Helius , Duwiri Daniel
Published: December 2021

Background: Our research reveals factor measures, which are generated to encourage economics students to engage in scientific publication and research processes.
Research purposes: Availability of motivational models for scientific publications, as a form of developing economics students in the future.
Research methods: Estimation using Exploratory Factor Analysis (EFA) approach, with statistical tools Jeffreys's Amazing Statistics Program (JASP) version 0.16.0.0.
Research results: This study shows the accuracy of the model, including the calculated value of McDonald's and Cronbach's > 0.700, for the MSA value of 0.762, and the value of Bartlett's test < .001. For the correlation relationship, it is strengthened by the RMSEA number which is between 0.05-0.08. This study forms a 3 factor model for scientific publications of economics students.
Conclusion: This study estimates the factors that can encourage the scientific publication model of economics students. Several factors in this research model are in line with the findings of previous researchers. This study shows that the accuracy of the model includes the McDonald's and Cronbach's > 0.700, for the MSA value of 0.762, and the Bartlett's test value < .001. For the correlation relationship, it is strengthened by the RMSEA number which is between 0.05-0.08. Thus, there are 3 factors in this model, namely the role of lecturers and families, students' basic abilities, and academic achievement goals. We realize that there are several theoretical challenges and measurement models, therefore further research is carried out using statistical test instruments and tools such as AMOS, PLS, and LISREL.
Pengaruh Kualitas Pelayanan Medis Terhadap Kepuasan Pasien pada Puskesmas Janjimatogu
Authors: Hasibuan Oktavia , Yuliana Hutapea Joan
Published: December 2021

Latar belakang: Kesehatan merupakan hal yang paling penting bagi semua manusia. Segala upaya akan dilakukan untuk mendapatkan kesehatan yang maksimal.Tujuan penelitian: Untuk mengetahui pengaruh kualitas pelayanan medis terhadap kepuasan pasien pada Puskesmas Janjimatogu secara parsial.Metode penelitian: Penelitian ini menggunakan jenis penelitian deskriptif dengan pendekatan kuantitatif. Teknik analisa yang digunakan yaitu uji instrumen, statistik deskriptif, regresi linear sederhana dan hipotesis t. Penelitian ini menggunakan Probability sampling sebagai teknik pengumpulan sampel dan populasi dan menggunakan sampel sebanyak 100 responden.Teknik pengolahan data menggunakan SPSS versi 23.Hasil penelitian: Kualitas pelayanan medis dengan dimensi bukti fisik, kehandalan, ketanggapan, jaminan, empati berpengaruh positif secara signifikan dengan hasil yang diperoleh sebesar 8,441 > t tabel 0,1946 dengan signifikasi value sebesar 0,000 < 0,005. Kualitas pelayanan dalam koefisien determinasi menunjukkan 41,5 % yang artinya bahwa 41,5 % kualitas pelayanan dapat memperngaruhi kepuasan pasien. Dari hasil statistik deskriptif memperoleh nilai yang menunjukkan bahwa ketanggapan memiliki nilai terendah sebesar 3,89 dari dimensi kualitas pelayanan.Kesimpulan: Penelitian ini menunjukkan bahwa variabel kualitas pelayanan medis secara parsial berpengaruh positif terhadap kepuasan pasien pada Puskesmas Janjimatogu. Hal ini dibuktikan dengan nilai uji t yang memiliki nilai signifikan sebesar 0.000 < 0.05 dan nilai t hitung 8.441 > 1.946. Variabel kualitas pelayanan terdapat indikator Assurance (Jaminan) dengan nilai tertinggi sebesar 4.05 dan Responsiveness (Ketanggapan) memiliki niai terendah sebesar 3.89. Variabel kepuasan pasien terdapat indikator mutu pelayanan memiliki nilai tertinggi sebesar 4.02 dan proses pelayanan memiliki nilai terendah sebesar 3.88.
Polka, nauczycielka, katoliczka - Emma Nicolay de Caprile
Authors: Pielacińska Nina , Seniów Adrianna
Published: December 2021

Celem niniejszego artykułu jest przybliżenie sylwetki Emmy Nicolay de Caprile – pochodzącej z Polski wybitnej nauczycielki, pionierki argentyńskiego systemu edukacyjnego. W Polsce jest to postać zupełnie nieznana, więc publikacja stanowi uzupełnienie pewnej luki w badaniach nad emigracyjnymi losami Polaków, tym bardziej, że Nicolay de Caprile była i jest nadal ambasadorem polskości, bowiem Argentyńczycy mają świadomość jej korzeni. W rozważaniach odwołamy się do kontekstu historycznego, omówimy etapy kształtowania się argentyńskiego systemu edukacyjnego w drugiej połowie XIX wieku. Na tym tle ukażemy nie tylko biografię Emmy Nicolay de Caprile, ale przede wszystkim jej rolę w propagowaniu edukacji dziewcząt, omówimy też sygnalnie zaproponowaną przez nią metodę nauki czytania i pisania, dzięki której poziom analfabetyzmu w Argentynie znacząco się zmniejszył. Podstawę dla naszych rozważań stanowi korespondencja Nicolay de Caprile z ówczesnym prezydentem Argentyny Domingo Faustino Sarmiento, zgromadzona w Archivo Histórico de la Escuela Normal Nº 1 w Buenos Aires, wspomnienia uczennic oraz materiały zarówno z argentyńskiej, jak i polonijnej prasy.
Życie i działalność Wolfganga Brezinki a jego koncepcja nauki o wychowaniu
Authors: Szewczak Iwona
Published: December 2021

W artykule została podjęta problematyka kształtowania się myśli pedagogicznej zmarłego w 2020 roku teoretyka nauk o wychowaniu obszaru niemieckojęzycznego Wolfganga Brezinki. Uwzględniono pochodzenie i okres młodości, czas studiów oraz początki kariery zawodowej (naukowej) w Instytucie Pedagogiki Porównawczej w Salzburgu. Niejednokrotnie trudne i często zaskakujące doświadczenia Brezinki wpłynęły na realistyczny profil jego koncepcji pedagogiki i wychowania oraz przyczyniły się do akcentowania w niej zależności teorii i praktyki wychowawczej.
Działalność Czesława Czapówa w oddziałach partyzanckich na Kielecczyźnie w czasie drugiej wojny światowej (1939-1945)
Authors: Skuza Aneta
Published: December 2021

Czesław Czapów z Uniwersytetu Warszawskiego zapisał się na stronach polskiej nauki jako twórca warszawskiej szkoły resocjalizacji. W 2020 roku, minęło 20 lat od Jego nagłej, przedwczesnej śmierci. Pozostawił po sobie wybitne dzieła, które po dziś dzień stanowią podstawową lekturę z zakresu nauk o resocjalizacji. Pozostał także w pamięci swych kolegów, którzy tak naprawdę niewiele wiedzą o Jego życiu prywatnym, czy wczesnych latach dzieciństwa. Prezentowany tekst ma na celu przybliżenie jednego z bardzo interesujących (a zarazem zupełnie nieznanych) wątków z życia Czesława Czapówa, a mianowicie Jego działalności w oddziałach partyzanckich podczas II wojny światowej na Kielecczyźnie. Jednocześnie stanowi on fragment przygotowywanej większej pracy związanej z Jego osobą. Prowadzone badania wpisują się w nurt badań jakościowych, a ich specyfika wymaga zastosowania swoistej metodologii zbierania danych, opartych na badaniach historycznych, biograficznych, historyczno-oświatowych, historyczno-pedagogicznych. Zastosowałam przy tym triangulację metod i danych. Źródłem informacji o działalności Czesława Czapówa w czasie II wojny światowej, na podstawie których opracowałam poniższy tekst są materiały źródłowe, archiwalne, artykuły z prasy, dokumenty i fotografie, wywiad oraz dostępna literatura przedmiotu w omawianej tematyce.
POSSIBILITIES OF COMPLEX CORRECTION OF MORPHOLOGICAL GASTRODUODENAL CHANGES WITH COMORBIDITY OF CHRONIC PANCREATITIS AND CHRONIC H. PYLORI – GASTRITIS
Authors: Makhnitska Iryna V. , Babinets Liliya S.
Published: December 2021

The aim: To investigate the efficacy of Doctovit, a combination of dexpanthenol (provitamin B5) and methylmethionine (vitamin U), in the treatment of patients with chronić pancreatitis in combination with chronic erosive gastritis associated with H. pylori by studying the dynamics of stomach lining morphological changes.
Materials and methods: Forty-five outpatients with CP and H.pylori CG were examined. The degree of excretory insufficiency of the pancreas was determined by the level of fecal α-elastase-1. At the beginning of the study and two months after the treatment has started, esophagogastroduodenoscopy + urease test for H. pylori + biopsy from 5 sites with histological examination has been performed.
Results: It was found that a significant decrease in lymphohistiocytic infiltration of stomach lining, restoration of the structure of glands which have not undergone atrophy, increased focal hyperplasia (proliferation) of the glandular epithelium as signs of morphological restoration of the epithelium, reduction of epithelial dysplasia signs against the complete absence of positive dynamics of epithelial dysplasia in the group of patients receiving standard treatment of CP and CG, are clear and reliable signs of the effectiveness of vitamin Doctovit in complex therapy of CG associated with H.pylori, which indicate the feasibility of using the medicine to restore SL, which is the basis for effective carcinoprevention.
Conclusions: The effectiveness of both treatment complexes in the correction of exocrine insufficiency of the pancreas by the dynamics of fecal α-elastase-1 was proved and which was statistically significantly higher when using the program with the inclusion of Doctovit: respectively 28.12% vs. 20.74% (p< 0.05). The total dynamics of morphological state improvement of stomach lining in the 1st group of patients was 0.9 points against 1.6 points in the 2nd group of patients, which was 17% and 32%, respectively (p <0.05), which activates clinical data on the effectiveness and feasibility of using a combination of dexpanthenol and methylmethionine according to the suggested scheme in the treatment of patients with chronic pancreatitis in comorbidity with H. pylori erosive CG.
PERFORATIVE PERITONITIS IN NEWBORNS: INSTRUMENTAL AND MORPHOLOGICAL EXAMINATION FINDINGS
Authors: Gorbatyuk Olga M. , Martyniuk Taras V.
Published: December 2021

The aim: To study and analyze the results of instrumental diagnostic measures and morphological verification of perforations of abdominal viscera in peritonitis in newborns, their importance in timely diagnosis, as well as to present authors’ experience of examining newborns with PP, taking into account the complexity of diagnosis and treatment of these patients.
Materials and methods: The study is based on the results of examining 59 newborns with PP of various etiologies. Instrumental methods that were used in the diagnosis of PP and differential diagnosis of other emergencies involved the following: radiological examination (plain abdominal radiography), abdominal and retroperitoneal ultrasound, neurosonography, echocardiography, diagnostic abdominal paracentesis. Morphological verification of hollow viscus perforations was performed by methods of histologic examination in 54 newborns who underwent surgery.
Results: It is emphasized that perforations in NEC and spontaneous gastrointestinal perforations have clinical and morphological differences. The analysis of morphological data showed absence of intestinal musculature or muscular wall defect in spontaneous gastrointestinal perforations. Perforations in NEC had massive gastric or bowel wall necrosis. Morphogenesis of gastrointestinal perforations in newborns is crucial for developing correct treatment strategy and choosing surgical approach.
Conclusions: Diagnosis of PP in newborns should be comprehensive and include modern instrumental studies that enable to reliably establish the cause of peritonitis and indications for surgical treatment. Differential diagnosis of PP in newborns with other diseases aims to differentiate PP from a number of similar clinical symptoms of urgent conditions in order to conduct adequate preoperative preparation and appropriate surgery. Diagnostic markers of PP involve the following: pneumoperitoneum, free fluid in the abdomen, sentinel loop (intestinal distention), fixed bowel loop, cloudy brown or greenish intra-abdominal fluid with a large number of leukocytes and bacteria.
EVALUATION OF PARAMETERS OF ACTUAL TYPICAL PATHOGENETIC SYNDROMES IN COMORBIDITY OF TYPE 2 DIABETES MELLITUS AND CHRONIC PANCREATITIS
Authors: Redkva Olena V. , Babinets Liliya S. , Halabitska Iryna M.
Published: December 2021

The aim: To assess the state of typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) in the comorbidity of type 2 diabetes mellitus (DM2) and chronic pancreatitis (CP).
Materials and methods: We examined 137 patients (112 patients with comorbidity of CP and DM2 and 25 patients with isolated CP. Typical pathogenetic syndromes (inflammation, endotoxicosis, liperoxidation, enzymatic and non-enzymatic antioxidant deficiency) were determined.
Results: It was proved that patients with CP even in the remission phase of the active course of EI and LPO, which was significantly more significant in comorbidity with DM2. Statistically significant more significant changes in the parameters of antioxidant protection in the comorbidity of CP and DM2 in relation to those in isolated CP.
Conclusions: Treatment of CP and DM2 is a difficult task and should take into account the impact on the studied common typical pathogenetic syndromes – inflammation, endotoxicosis, lipid peroxidation, and enzyme and non-enzymatic antioxidant protection – to address short-term and prevent long-term complications.
INTESTINAL LESIONS OCCURRING IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE AFTER SUFFERING THE COVID-19 INFECTION
Authors: Stehura Adelina V. , Sirchak Yelyzaveta S.
Published: December 2021

The aim: To investigate the effectiveness of determining the activity of faecal calprotectin for detecting colonic lesions in patients with nonalcoholic fatty liver disease who have had a COVID-19 acute respiratory infection.
Materials and methods: The study included 46 patients with non-alcoholic fatty liver disease NAFLD at the stage of outpatient observation after suffering a COVID-19 acute respiratory infection.
Results: One of the main clinical signs indicating intestinal lesions among the COVID-19-infected patients with NAFLD at the time of admission to hospital was diarrhea (identified in 43.5% of cases during the patients’ examination), as well as bloating and pain in the colon (identified in 26.1% and 32.6% of cases during the patients’ examination, respectively). The analysis of the data obtained indicates a slight increase in the level of faecal calprotectin among NAFLD patients infected with COVID-19 during hospital treatment, and in this regard the indicators did not exceed the reference values. A more pronounced deviation from the norm was observed 2 months after hospital treatment, namely, its increase to 101.6 ± 2.5 μg / L.
Conclusions: A frequent clinical manifestation of intestinal lesions among NAFLD patients infected with COVID-19 is defaecation disorder, which at the beginning of the disease is more often manifested through alternating diarrhea (up to 43.5%) and constipation (32.6% of the examined patients). NAFLD patients infected with the COVID-19 virus are diagnosed with an intensified activity of faecal calprotectin and α1-antitrypsin in the blood serum and faeces, as well as the clearance, and this indicates the presence of inflammatory changes in the colon, which requires conducting further research of these patients’ cases.
CORRECTION OF AUTONOMIC DYSFUNCTION IN YOUNG WOMEN BY OPTIMIZATION OF COMPONENT BODY COMPOSITION
Authors: Kentesh Oksana P. , Nemesh Marianna I. , Palamarchuk Olga S. , Savka Yulianna M. , Slyvka Yaroslava I. , Feketa Volodymyr P.
Published: December 2021

The aim: The article aims toevaluate the possibility of optimizing the state of the autonomic nervous system in almost healthy young females with different component body composition through physicalactivity and sensible nutrition.
Materials and methods: The study involved 30 young females. Body weight of women was measured both before and after the proposed weight correction program. Such parameters as body mass index (BMI, kg / m2),fat mass percentage(FMP,%),visceral fat content (VF,unit) and fat free mass content (FFM, %) using a bioimpedance analyser “TANITA BC-601”were measured. Also, the study of the state of the autonomic nervous system (ANS) based on the registration of the rhythmogram using the computer hardware complex “CARDIOLAB” (HAI – Medica) was carried out.
Results: Analysis of the results of the study revealed that the regulation of functions in women with suboptimal ratio of adipose and muscle tissues in the body was carried out mainly through suprasegmental levels of regulation (VLF%) and was accompanied by a decrease in the activity of segmental autonomic influences.At the same time, the theoretical assumption about the possibility of correction of autonomic disorders by normalizing adipose and muscle tissueswas experimentally confirmed.Under the influence of a two-month program of body weight correction an increase in the functional activity of the autonomic control loop and improvement of the internal structure of the spectrum of neuroautonomicregulation (reduction of VLF-oscillations and increase of LF-effects and HF-effects) in the examined women were observed.
Conclusions: Thus, physical activity and sensible nutrition have a positive effect on the rheology of adipose tissue and the mechanisms of regulation of body functions, so they can be used to correct their disorders.
THE EFFECTIVENESS OF COMPLEX THERAPY WITH THE INCLUSION OF THE URSODEOXYCHOLIC ACID IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Khramtsova Iryna O. , Derbak Maria A. , Ganich Taras M. , Boldizhar Oleksandr O. , Lazur Yana V.
Published: December 2021

The aim: Was increase the effectiveness of treatment in patients with non-alcoholic fatty liver disease (NAFLD) comorbid with chronic obstructive pulmonary disease (COPD) by using ursodeoxycholic acid (UDCA) in combination with ademethionine.
Materials and methods: Under observation was 98 patients with a diagnosis of NAFLD and COPD group II or their combination. Patients were divided into 3 groups: 1 (n = 36) – COPD + NASH – in addition to standard COPD therapy received UDCA 15 mg / kg / day – 6 months and ademethionine 1000 mg IV once a day for 10 days, followed by oral administration of 500 mg 2 times per day – 20 days, and group 2 (n = 32) – COPD + hepatic steatosis – in addition to standard therapy – UDCA 15 mg / kg / day – 6 months. Group 3 (n = 30) – COPD received standard therapy for COPD.
Results: UDCA with ademethionine on the background of standard COPD therapy reduces the clinical manifestations of NAFLD and normalizes liver function. The combination of UDCA with ademethionine not only has a positive effect on the course of NAFLD, but also reduces the intensity of dyspnea, systemic inflammation, improves the external respiration function and reduces anxiety and depression. Patients receiving UDCA + ademethionine for 6 months of follow-up had no exacerbations of COPD.
Conclusions: UDCA in combination with ademethionine in COPD courses have a positive effect on the course of NAFLD, and also reduces the intensity of dyspnea, improves the external respiratory function and reduces the frequency of COPD hospitalization.
ASSESSMENT OF THE IMPACT OF ANTIREFLUX THERAPY ON THE COURSE OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Liakh Olesya I. , Derbak Mariya A. , Sirchak Yelyzaveta S. , Tovt-Korshуnska Mariana I. , Lazur Yana V.
Published: December 2021

The aim: To examine the effect of antireflux therapy on the course of COPD.
Materials and methods: Under observation were 60 patients who were hospitalized in the «Transcarpathian Regional Clinical Hospital named after Andrei Novak» with a diagnosis of COPD II gr B in combination with GERD and 36 patients diagnosed with GERD who were treated on an outpatient basis. To study the effectiveness of antireflux therapy and its impact on the course of COPD, patients are divided into 2 groups: 1 group (main) (n = 60) – patients with COPD in combination with GERD, group 2 (control) (n = 36) – patients with isolated GERD. Patients with positive Helicobacter pylori status received antihelicobacter therapy. Patients in group 1 were divided into subgroups: 1a (n = 34) – COPD in combination with esophageal manifestations of GERD and 1b (n = 26) – COPD in combination with extraesophageal manifestations of GERD. Group 1a received complex therapy, which consisted of basic therapy of COPD in combination with antireflux and with rebapimide, group 1b – only basic therapy of COPD in combination with antireflux.
Results: After treatment, the clinical signs of GERD significantly decreased in all patients receiving complex therapy, improved the course of respiratory symptoms of COPD. After treatment, patients showed a clinically significant reduction in systemic inflammation, which is best seen in the group with the use of rabipimide.
Conclusions: Comprehensive treatment of combined pathology with the use of antireflux therapy has a positive effect not only on the clinical symptoms of the disease, but also on the indicators of external respiratory function in patients with combined COPD and GERD.
PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN
Authors: Maliar Vitaliy V.
Published: December 2021

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack.
Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women.
Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p <0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section.
Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.
INSULIN RESISTANCE AS AN INDICATOR OF DIFFERENTIATION FOR THE FORMATION OF RISK GROUPS FOR NON-ALCOHOLIC FATTY LIVER DISEASE IN PATIENTS WITHOUT TYPE 2 DIABETES MELLITUS, AS A PART OF ONTOLOGICAL MODEL OF NON-ALCOHOLIC FATTY LIVER DISEASE
Authors: Nosko Natalia O. , Kharchenko Viacheslav V.
Published: December 2021

The aim: Using cluster analysis, to identify a high-risk group for NAFLD and develop a differential approach to examination, treatment and prevention of the disease based on IR indices, among NAFLD and non-NAFLD patients without type 2 diabetes mellitus (T2DM).
Materials and methods: Clinical, anthropometric, laboratory methods, ultrasound, computational and statistical techniques were applied.
Results: Cluster analysis was performed on the laboratory tests results: glucose, insulin, HOMA-IR index, HOMA2 Calculator (%B – beta-cell function, %S – insulin sensitivity, IR – insulin resistance). 5 groups of patients were formed, according to increasing HOMA-IR index and IR. Group II was found to be transient in IR formation, it included the majority of non-NAFLD patients (87%), and we consider it to be the risk group for NAFLD. Group V – with the highest IR scores, where 92% of patients had NAFLD and 73% had a high Fatty Liver Index – is considered to be a very high-risk group for developing T2DM.
Conclusions: 1. According to the results of cluster analysis, 5 groups of patients with different IR levels were identified. 2. In the second group, where non-NAFLD patients predominate, insulin resistance begins to form. 3. Groups III and IV – patients with high HOMA-IR index – had significant ultrasound findings indicating hepatic steatosis. 4. Group V included patients with NAFLD, with high HOMA-IR index and the highest risk of developing T2DM.
RISK PREDICTION FOR ARRHYTHMIA IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
Authors: Ternushchak Tetyana M. , Tovt-Korshynska Marianna I.
Published: December 2021

The aim: To evaluate P-wave dispersion (PwD), as an independent predictor of atrial fibrillation, corrected QT interval dispersion (cQTD), the noninvasive marker of ventricular arrhythmia and sudden cardiac death, investigate the atrial electromechanical delay in patients with COPD and assess their relation with the severity of the disease.
Materials and methods: We prospectively enrolled consecutive patients with newly diagnosed COPD (n = 53, age 41.2 ± 6.8 years), compared with an age-matched healthy control group (n = 51, age 40.9 ± 6.5 years). A standard 12-lead electrocardiogram of each patient was analyzed for PwD and сQTD. Atrial electromechanical delay was analyzed by echocardiographic tissue Doppler imaging. The difference between PAs-PAl, PAs-PAt, and PAl-PAt were defined as left intra-atrial, right intra-atrial, and interatrial electromechanical delays (EMD), respectively.
Results: PwD was higher in COPD patients than in control subjects (39.47 ± 3.12 ms vs. 30.29 ± 3.17 ms, p < 0.05). In comparison between control group and COPD subgroups (mild, moderate and severe), there was a statistically significant difference among these free groups in terms of PwD. Subgroup analyses showed that this difference was mainly due to patients with severe COPD. Regarding cQTD, there was a statistically significant increase in COPD patients 57.92 ± 3.43 ms vs 41.03 ± 5.21 ms, p < 0.05 respectively. PAs, PAl and PAt durations, right intra-atrial and interatrial EMD were also significantly longer in COPD patients (p < 0.05). Furthermore, there were significant negative correlations between FEV1 and PwD (r = – 0.46, p < 0.05), right intra-atrial (r = – 0.39 ms, p < 0.05), interatrial EMD ( r = – 0.35 ms, p < 0.05) and cQTD (r = – 0.32, p < 0.05).
Conclusions: Atrial conduction time, such as inter- and intra-atrial EMD intervals, PwD and cQTD were longer than in healthy controls and correlated with the severity of COPD. These parameters offer a non-invasive and cost-effective assessment method for detecting patients at high risk of arrhythmia. Nevertheless, further prospective investigations on this issue are required.
EFFECTS OF BIOLOGICAL THERAPY ON QUALITY OF LIFE AND PSYCHOEMOTIONAL STATUS OF PATIENTS WITH ULCERATIVE COLITIS
Authors: Varvarynets Antonina V.
Published: December 2021

The aim: To compare the effects of tofacitinib, adalimumab and budesonide on the quality of life and psychoemotional status of patients with moderate UC.
Materials and methods: The study included 104 patients with moderately severe UC aged between 18 and 75 years old. Patients were divided into 3 groups. Group I consisted of patients with UC treated with budesonide 9 mg 1 g / d (BUD; n = 34). Group II – of patients receiving adalimumab at an initial dose of 160 mg and 80 mg at week 2, followed by maintenance dose of 40 mg weekly (ADA; n = 38) and group III, who received tofacitinib 10 mg 2p / d (TOF; n = 32). Evaluation of quality of life and psycho-emotional status of patients was performed using IBDQ, SF-36 and MMRI questionnaires.
Results: According to the IBDQ-questionnaire, all groups after treatment had a statistically significant increase in their results: BUD (from 146,44 ± 2,23 to 151,36 ± 2,40), ADA (from 144,28 ± 3,10 to 172,36 ± 3,12), TOF (from 149,22 ± 2, 86 to 184.36 ± 2.88), respectively, p <0.05. Also, after treatment statistically significant changes were seen in patients of all groups in regards to the psychological and physical components of the SF-36 scale. Analysis of the personality profile using MMRI of all groups of patients showed a change in scales 2 (depression), 3 (hysteria), 5 (tenderness-femininity), 6 (paranoia) and 0 (social introversion), which significantly improved in the ADA and TOF groups.
Conclusions: Tofacitinib and adalimumab in patients with nonspecific ulcerative colitis of moderate severity had a better effect on quality of life and psychoemotional status compared with budesonide treatment.
A COMPARATIVE STUDY OF LIPID PROFILE AND LEPTIN RESISTANCE IN CHILDREN WITH METABOLIC SYNDROME DEPENDING ON HYPERTENSION IN KYIV
Authors: Aliusef Maiia H. , Churylina Alina V. , Gnyloskurenko Ganna V. , Mitiuriaeva Inga O. , Maidannyk Vitaliy G.
Published: December 2021

The aim: To compare lipid metabolism and leptin levels among the children with and without hypertension to identify associated risk factors for the course of metabolic syndrome in children.
Materials and methods: This observational, cross-sectional study recruited children from the Rheumocardiology Department of Children’s Clinical Hospital No 6 in Kyiv, with metabolic syndrome, identification of waist-to-height ratio, leptin level, homeostasis model assessment of insulin resistance and lipid profile. The main group included 41 children with metabolic syndrome and hypertension and the control group included 40 children with metabolic syndrome without hypertension. Statistical data analysis was performed using the MedStat 2.6.2. package.
Results: A total of 81 children aged 10 to 17 with metabolic syndrome were examined. The group of children with hypertension had significantly lower high-density lipoprotein cholesterol (0.85±0.04) than children without hypertension (0.94±0.03), with p < 0.05. Leptin resistance was detected in 65.2% of children with hypertension and 35.3% of children with normal blood pressure (p < 0.01).
Conclusions: Children with metabolic syndrome and hypertension had a significantly higher body mass index and waist circumference as opposed to children with normal blood pressure. In the lipid profile high-density lipoprotein cholesterol was significantly lower in hypertensive children. There was no reliable difference in other lipid profile indicators between the two groups, but there was an upward trend of them in group with hypertension. Leptin resistance is also significantly higher in hypertensive children.
THE CLINICAL PRESENTATION OF SUBCLINICAL HYPOTHYROIDISM IN PATIENTS WITH TYPE 2 DIABETES MELLITUS ASSOCIATED WITH OBESITY, ITS IMPACT ON CARDIOVASCULAR RISK, AND WAYS OF ITS CORRECTION
Authors: Griadil Taras I. , Chopey Ivan V. , Chubirko Ksenia I. , Feysa Snizhana V.
Published: December 2021

The aim: Calculate CVR in patients with T2DM, obesity and SH and analyze it.
Materials and methods: The selection of patients was carried out based on the Uzhhorod District Clinical Hospital, in the period from November 2016 to July 2021. All examined patients were divided into 3 groups: 1 (n=108) with T2DM and concomitant obesity and SH, 2 (n=91) with T2DM and SH, 3 (n=46) with obesity and SH. The observation and treatment period lasted 1 year. Using American College of Cardiology (ACC) / American Heart Association Guideline on the Assessment of Cardiovascular Risk (AHAGACR) (2013) (ASCVD Risk) and Framingham Risk Score (FRS), CVR was determined in all patients before and at the end of the study.
Results: According to the data obtained, patients in each group had a 10-year risk of CVE, however, worse CVR was observed in patients in group 1. In a more detailed analysis and comparison of the obtained data of patients with 10-year risk of CVE, worse CVR values were observed in patients with concomitant SH than without it (p<0.05).
Conclusions: The presence of SH in consumers may be an additional risk factor for unwanted CVE over a 10-year period.
FEASIBILITY OF CYSTATIN C DETERMINATION FOR EARLY DIAGNOSIS OF KIDNEY DAMAGE IN PATIENTS WITH TYPE 2 DIABETES COMBINED WITH NONALCOHOLIC FATTY LIVER DISEASE AND OBESITY EXPOSED TO COVID-19 INFECTION IN THE PAST
Authors: Sabovchyk Kateryna V. , Sirchak Yelyzaveta S. , Stryzhak Vasyl V.
Published: December 2021

The aim: To examine the diagnostic possibilities of determining the level of cystatin C in the blood serum in order to ascertain the functional status of the kidneys in patients with type 2 diabetes (those who recovered from COVID-19 infection) depending on the presence or absence of non-alcoholic fatty liver disease (further – NAFLD) and malnutrition.
Materials and methods: We investigated 18 patients with type 2 DM, who were included in the first group of the patients examined; group 2 consisted of 20 patients with type 2 DM and non-alcoholic fatty liver disease (NAFLD), namely with non-alcoholic steatohepatitis; and group 3 of the patients examined consisted of 30 patients with type 2 DM and obesity.
Results: Renal damage in patients with metabolically associated diseases in the background of respiratory disease due to COVID-19 infection was also indicated by changes in urine test indicators, and namely – proteinuria and erythrocyturia, leukocyturia in urine sediment. The examination of cystatin C (Cys C) level indicates its statistically significant increase in patients of all examined groups, with the highest levels established in group 3 patients (with its increase up to 2.58 ± 0.11 mg/L, compared with the norm of 0.75 ± 0.04 mg/L in the control group – p < 0.01). The examination of GFR by calculation, where the Cys C index in serum was used, revealed a significant decrease in this parameter in all the examined groups of patients. At the same time, the maximum values were found in group 1 patients (65.7 ± 1.4 ml/min per 1.73 m2 of the body surface), and the minimum values – in group 3 patients (48.3 ± 2.7 ml/min per 1.73 m2 of the body surface).
Conclusions: An increase in serum cystatin C levels was determined in type 2 diabetes patients, with the lowest level in group 1 patients (1.24 ± 0.07 mg/L – p < 0.05), and the highest level in patients suffering from type 2 diabetes combined with NAFLD and obesity (2.58 ± 0.11 mg/L – p < 0.01). A moderate to severe course of COVID-19 infection in patients with type 2 diabetes as well as with its combination with NAFLD and obesity contributes to the development of renal functional disorders in these patients. Moreover, an increase in serum Cys C levels is a more sensitive and earlier marker of renal damage development in comorbid pathology.
ALGORITHM OF COMPLEX REHABILITATION OF PATIENTS WITH IATROGENIC OCCLUSAL DISORDERS COMBINED WITH VERTICAL MALOCCLUSION
Authors: Tereshchuk Olena G. , Nespryadko Valeriy P. , Flis Petro S. , Shynchukovskyi Igor A. , Holubchenko Olena Yu. , Palyvoda Roman S.
Published: December 2021

The aim: To propose the algorithm of complex rehabilitation of patients with iatrogenic occlusal disorders combined with vertical malocclusion and prove its efficiency. Materials and methods: 55 patients with iatrogenic occlusal disorders combined with vertical malocclusion aged from 23 to 47 years old (mean age 36.1±5.2 years) including 32 females and 23 males were examined at Dental Medical Center of Bogomolets National Medical University during 2019-2021 years. All patients before and 6 months after treatment underwent clinical and laboratory examination, X-ray, electromyography, T-Scan Digital Occlusal Analysis. Results: In all 3 groups of patients we observed complete disappearance or significant reduction of complaints and symptomatic manifestations after 6 months of complex rehabilitation. Conclusions: Our study showed that the proposed algorithm of complex rehabilitation of patients with iatrogenic occlusal disorders combined with vertical malocclusion, which provides a multidisciplinary and individualized approach, improves the efficiency of orthodontic treatment of such patients and significantly reduces the duration of treatment in all 3 groups. This sequence of diagnostic and treatment measures gives the best opportunities for the patient to achieve maximum functional and aesthetic result.
LEGAL REGULATION OF HUMAN ORGANS AND TISSUE TRANSPLANTATION: INTERNATIONAL AND FOREIGN EXPERIENCE
Authors: Rogach Oleksandr Ya. , Potapchuk Anatoliy M. , Popovych Tereziia P. , Maslyuk Oksana V.
Published: December 2021

The aim: To highlight and analyze the international aspect of the legal regulation of human organs and tissues transplantation, as well as foreign experience of regulation in this area within the relevant national legal systems (for example, US, Germany, Israel, Switzerland, Spain, Argentina, China and India).
Materials and methods: Methodologically, this work is based on the system of methods, scientific approaches, techniques and principles with the help of which the realization of the research aim is carried out. There have been applied universal, general scientific and special legal methods.
Conclusions: Thus, the efforts of the international community and the countries under study in the field of transplantation are focused on a wide range of important issues that need to be regulated. The international legal regulation of transplantation covers the results of the activities of such international organizations as the World Health Organization, the Council of Europe, and the World Medical Assembly. The acts adopted by them are mainly of a recommendatory nature (with the exception of some Council of Europe acts on trafficking in human organs) and are addressed primarily to States, offering guidelines and standards for the legal regulation of transplantation within national legal orders. Therefore, the issues of donation and transplantation of human organs and tissues in the respective states are determined by special legislative acts, which comprehensively regulate the procedure for their transplantation.
COVID-19 AND PRIMARY CARE: POSSIBILITIES FOR INCREASING POSITIVE OUTCOMES
Authors: Kurakh Artur V. , Hechko Mykhaylo M. , Chopey Ivan V.
Published: December 2021

The aim: Determine the most common non-communicable diseases which are associated with an increased rate of moderate and severe COVID-19 infection. Identify the best tools for diagnosing COVID-19 and predicting the deterioration of the disease.
Materials and methods: Publications were processed and analyzed according to the keywords of the topic of work “COVID-19”, “non-communicable disease”, “obesity”, “hypertension”, “Comorbidities”, “frailty”, “diabetes”, “chronic obstructive pulmonary disease”, “cardio-vascular diseases”, “liver diseases”, “diagnostic tools”, “outcomes” in the databases of PubMed, MEDLINE, Web of Science.
Conclusions: As a result of the analysis, we found that patients with concomitant obesity, diabetes mellitus, COPD, CVD and liver diseases have an increased the risk of severe forms and death from COVID-19.
ESSENCE OF SOMATIC HUMAN RIGHTS IN THE PROCESS OF BIOMEDICAL RESEARCH
Authors: Bielov Dmytro M. , Hromovchuk Myroslava V. , Hretsa Yaroslav V. , Tymchak Vasyl V.
Published: December 2021

The aim: To study the constitutional and legal principles and the influence of various factors on the mechanism of realization of somatic rights in the process of biomedical research.
Materials and methods: Formal-logical methods of analysis and synthesis allowed to reveal the content of the concepts that make up the subject of research, to classify them, as well as to formulate intermediate and general conclusions. The systematic method allowed to study the role and significance of somatic human rights among other human and civil rights and freedoms. Using the historical method, the doctrinal basis of the study was analyzed, and the main stages of the formation of biomedical research with human participation were identified.
Conclusions: The historiography of somatic human rights in biomedical research in a broad sense is a field of scientific knowledge. Studies the development of constitutional and legal science and its patterns; in the narrow sense, it is a set of works on various problems of the history of modern constitutionalism, human rights, the influence of religion on human rights and the mechanism of their implementation and protection in a certain historical period.
PERINATAL ASPECTS OF INTRAUTERINE INFECTIONS
Authors: Korchynska Oksana O. , Andrashchikova Stefania , Zhultakova Sylvia , Shlosserova Alena
Published: December 2021

The aim: To analyze Ukrainian and foreign literature data on the consequences of perinatal infection and the peculiarities of their manifestation.
Materials and methods: Literature sources on the peculiarities of the course of infection that occur in the perinatal period and are a threat of congenital malformations or diseases in the newborn are collected.
Conclusions: The analyzed data of the clinical picture and management of the early neonatal period fully reflect the coherence and timeliness of medical care for infants born with signs of perinatal infection. It should be noted that the tactics of such a newborn depend on the clinical manifestations, the general condition of the baby, and the duration of infection of the mother with a particular infection.
THE HUMAN RIGHT TO STERILIZATION: MEDICAL AND LEGAL ASPECT
Authors: Fridmanskyy Roman M. , Fridmanska Viktoria I. , Dir Ihor Yu. , Kopcha Vasyl V.
Published: December 2021

The aim: To consider the general principles of the human right to sterilization in terms of medicine and law.
Materials and methods: Formal-logical methods of analysis and synthesis allowed to reveal the content of the concepts that make up the subject of research, to classify them, as well as to formulate intermediate and general conclusions. The systematic method allowed to study the role and significance of right to sterilization among other human rights and freedoms. Using the historical method, the doctrinal basis of the study was analyzed, and the main stages of the formation of category “right to sterilization” with human participation were identified.
Conclusions: The issue of surgical sterilization should not be considered during contractions, as happened in this particular case, but before or after childbirth, because a woman in childbirth can not adequately perceive information and make such important decisions. If this decision is made after delivery, the doctor must make sure that the patient is psychologically healthy. In addition, the consent for surgical sterilization of the spouses must be signed together. Although this procedure follows from the human right to dispose of one’s own body, however, in the presence of marriage, referring to Part 2 of Art. 54 of the IC of Ukraine, which states that all important issues of the family should be resolved by the spouses together, on the basis of equality. If such a decision is made by the wife alone, she must be considered to have committed the wrongful conduct.
EXTENSIVE PERITUMORAL BRAIN EDEMA IN A SMALL CLINOIDAL MENINGIOMA: CLINICAL CASE
Authors: Nassar Abdalrahman , Smolanka Volodymyr I. , Smolanka Andriy V.
Published: December 2021

Peritumoral brain edema (PTBE) is seen in 40-78% of all cases of intracranial meningiomas. It may vary in shape and size, occasionally being two to three times larger than the tumor. We present a case of a 62-year-old female patient, suffering from seizure and progressive headache. She was diagnosed with left medial sphenoid wing meningioma and referred for treatment to Uzhhorod Regional Center of Neurosurgery and Neurology. The patient had no major focal neurological deficit and Karnofsky Performance Scale (KPS) of 70 on admission. The preoperative magnetic resonance imaging (MRI) with and without contrast showed a 2.1×2.2×2.5 cm solid mass at the inner third of the left sphenoid wing, with homogenous enhancement and encasement of middle cerebral artery (MCA). In addition, there was a disproportionately extensive PTBE in the left cerebral hemisphere that caused midline shift and mass effect. The patient underwent left pterional craniotomy and gross total resection of the mass. The postoperative course was without complications or new neurological deficit, MRI within 48 hours revealed gross total tumour resection with residual brain edema and the patient was discharged with a KPS of 80 on day 7. Based on several studies, significant correlation between PTBE and tumor volume was observed: larger tumors cause larger PTBE. This particular case had a very large hemispheric PTBE, which was disproportionate to the small size of the meningioma. Most likely, the PTBE in this patient was caused by venous congestion, but this had no influence on surgical outcome. Therefore, the presence of a large PTBE does not necessarily indicate a poor prognosis and isn’t always the reason of surgical complications.
Assessment of woody plant species composition in secondary deciduous forests of Odisha, India
Authors: Pattnayak Subhashree , Behera Rajendra Kumar , Sahu Sudam Charan , Dhal Nabin Kumar
Published: December 2021

Plant species composition according to their functional types, distribution pattern are crucial for biodiversity conservation in tropical deciduous forest. The study assessed the woody plant species diversity, stand structure and population density in the secondary deciduous forest of Chandaka wildlife sanctuary, Odisha, India. A total of 70 species belonging to 63 genera and families were documented in this study.The stem density was found to be 1080 stems/ha with reverse J-shaped population structure indicating good regeneration potential of the forests. Shannon diversity Index varied from 0 to 2.31 whereas Simpson's index varied from 0 to 0.85. The correlation study between Importance Value Index and basal area were significant (p=40.63). The present study would be helpful for conservation and management of biodiversity in secondary dry deciduous forests of Chandaka Wildlife Sanctury in particular and tropical dry forests in general.