bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on the Impact of Short Videos on Urban Tourism Economy—Taking Douyin as an Example
Authors: Jia Congcong , Long Yijie , Xu Jinyang , Liu Xin
Published: October 2024

Under the background of global tourism, the pace of development of tourism is getting faster and faster. In some areas, tourism has become an indispensable element to promote regional economic development. With the continuous maturity of the new media environment, it has created a new way for urban tourism promotion and promoted urban tourism marketing to a certain extent. Douyin short video is the "outstanding" among the new media, with a large base of young users, and has gradually become an important position for urban tourism marketing. If the vibrato short video can be used reasonably and fully integrated with urban tourism marketing, greater tourism economic benefits can be obtained. Based on this, this article analyzes the role of Douyin short video in urban tourism marketing and puts forward relevant suggestions.
Atividade de integração ensino-serviço-comunidade com foco na educação interprofissional: significados para o trabalho em equipe
Authors: Paula Gabriel Brazil de , Souza Renyelle Schwantes de , Toassi Ramona Fernanda Ceriotti
Published: October 2024

Introdução: Educação interprofissional (EIP) com estímulo a práticas colaborativas tem potencial para melhorar a experiência de cuidado em saúde. Objetivo: Compreender o significado da atividade de integração ensino-serviço-comunidade, orientada pelas bases teóricas da EIP, para o processo de trabalho em equipe na Atenção Primária à Saúde (APS). Métodos: Pesquisa de abordagem qualitativa fenomenológica. Entrevistas individuais semiestruturadas foram realizadas com agentes comunitários de saúde (ACS), gestores da APS e residentes. O material foi interpretado pela análise de conteúdo, apoiada pelo software Visual Qualitative Data Analysis (ATLAS.ti). Resultados: Participaram do estudo 15 ACS, cinco gestores e dois residentes (n=22). Por meio de dinâmica pedagógica interativa, a atividade de EIP possibilitou troca de saberes/experiências e aprendizado compartilhado entre profissões da saúde. Destacou o conhecimento sobre o papel profissional/valorização de ACS, estimulando a disponibilidade para o aprender e ensinar. Produziu espaços de discussão de casos/situações que trouxe novas possibilidades de pensar-agir saúde. A construção coletiva de ferramentas de cuidado oportunizou sua incorporação ao trabalho das equipes, o que motivou os profissionais e qualificou o cuidado aos usuários-famílias. Diferenças de reconhecimento/valorização que determinadas profissões apresentam para os usuários foram percebidas por ACS. Conclusões: A interação entre profissões no cotidiano do trabalho promoveu o desenvolvimento de competências colaborativas voltadas à comunicação interprofissional, ao conhecimento sobre o papel de cada núcleo dentro do processo de trabalho em equipe e ao cuidado centrado no paciente/usuário. Novas pesquisas são recomendadas, analisando os efeitos da contratualização da APS e as mudanças na Política Nacional de Atenção Básica na educação/trabalho interprofissional.
Non-traditional Interpretation of ECG Signals: Uncovering Hidden Data for Multimodal Health Monitoring
Authors: Velikic Gordana , Ruangsuwana Rangsal , Bocko Mark , Pentland Alice
Published: October 2024

In this paper we present the benefits of long-term ECG data collection. Extraction of “nontraditional” variables and multimodal information from ECG signals can be used to estimate current, predict future health status, and detect any health anomalies and trends of an individual before subjective signs appear.
An Image Compression Method for Fleck Board-3
Authors: Enesi Indrit , Çiço Betim
Published: October 2024

The recent availability of inexpensive hardware, such as CMOS and CCD cameras, has enabled the new research field of wireless multimedia sensor networks. This is a network of interconnected devices, capable of retrieving multimedia content from the environment. In this type of network, the nodes usually have very limited resources, in terms of processing power, bandwidth and energy. Efficient coding of the multimedia content is therefore important. A new image compression codec, suitable for this type of network was developed, a very high compression ratio can be achieved, the compression rate varies depending on the content but it is usually between 90% and 99% compared to the previous camera network.
The Influence of Stitch Density and of the Type of Sewing Thread on Seam Strength
Authors: Barbulov – Popov Daniela , Cirkovic Nenad , Stepanović Jovan
Published: October 2024

Having in mind the complex problems of technological process of sewing, as well as general demands for seams produced in garment production, this research should contribute the development of sewed seams breaking forces. Thus, many measurements of seam breaking forces have been conducted. These measurements enable us to define optimal strength of seam strength that improves the compliance of sewed seams parameters. This paper deals with the influence of the thread type and stitch density on the seam strength. The breaking forces and elongations at break were determined by the standardized method (SRPS 2062) and fabric (tape method) according to SRPS EN ISO 13934-1. Fabric samples used for seam testing were sewed by seam (1.01.01) and stitch type 301 with stitch densities 3, 4 and 5 cm-1. Optimal seam strength (130.9 Ncm-1) on the fabric T71, and at the same time the highest strength, has been noticed at the samples with seam line in weft direction with stitch density 5 cm-1, sewed with polyester thread 20x2 tex count, while on fabric T71 that value is 115.9 Ncm-1. According to obtained
results, it can be concluded that stitch density (3 cm-1 ÷ 5 cm-1) and the type of sewing thread (cotton and polyester, K1 ÷ K5) have great influence on defining seam sttrength, their inconsistency may lead to great differences in seam behavior.
Challenges and Prospects of the National Health Insurance Scheme and Medical Service Delivery in The Nigerian Navy.
Authors: I.B. Chukwuka , N.T. Mohammad , C.V. Chukwuka , C.O. Uko , DO. Babalola , P.E. Effa
Published: October 2024

Background: The National Health Insurance Scheme (NHIS) was introduced into the Nigerian Navy (NN) in December 2006.  It was meant to provide the alternative funding and technical imputes needed to revive the ailing medical service delivery in the NN. However, 5 years after the implementation of the Scheme, there are still problem of ‘out of stock syndrome’ of drugs while the quality of medical service delivery is still sub optimal. Hence, many NN personnel prefer to seek healthcare outside the Nigerian Navy Medical Service (NNMS). The aim of this study was to investigate the contributions of NHIS to medical service delivery in the NN, also to find out the challenges and prospects for optimizing the implementation of NHIS for enhanced medical service delivery in the NN.
Method: This study was a descriptive survey research. Primary data was collected using questionnaire and consultations. Secondary data was collected from books, official documents and publications, journals, internet, published and unpublished material. The data collected were analyzed and expressed as frequencies and percentages and thereafter presented in tables.
Results: The research findings showed a statistically significant relationship between NHIS and medical services delivery in the NN. It also revealed that the NHIS has contributed to the improvement of the NN medical service delivery. However, inadequate staffing, inadequate and obsolete medical equipment were found as challenges to optimal implementation of the Scheme for enhancing medical service delivery in the NN. Other challenges include poor attitude of medical personnel, insincerity in management of NHIS and exclusion of operational/occupational injuries.
Conclusion: In conclusion the study was able to establish a significant relationship between NHIS and medical services delivery in the NN.  It also ascertained the various contributions of NHIS to medical service delivery in the NN.     The study identified significant improvement in the quality of medical service delivery in the NN within the 5 years of implementation of the Scheme.
Cost Analysis of DPP4 and SGLT2 Inhibitors - “Dilemma of the Prescribing Physician - Which Brand to Choose?”
Authors:   Department of Pharmacology, Assam Medical College and Hospital, Dibrugarh, Assam, India, Saikia Hiteswar , Baruah Prabhat Ranjan , Saikia Anju L
Published: October 2024

Diabetes mellitus (DM) is a complex and heterogeneous group of chronic metabolic diseases causing dreaded complications increasing human sufferings, and a costly disease to manage in low/middle-income countries, which is burdensome for the most vulnerable populations, cause financial strain on individuals and family members. The purpose of the study was to analyze the price variability of different brands of sodium glucose co-transporter 2 inhibitors (SGLT2i) and dipeptidyl peptidase 4 inhibitors (DPP4i) and their combinations. The present study was an observational analytical one. The highest and lowest price of each SGLT2i and DPP4i in the same strength marketed by different pharmaceutical companies, were collected from Current Index of Medical Specialties (Jan–April 2023), Indian Drug Review (IDR 2023), Drug Today (April – July 2023) drug manuals. Calculations were done in Indian Rupees per 10 tablets/capsules. For each drug, the cost ratio and percentage of price variation (PPV) were calculated. Among DPP4i, sitagliptin 50 mg has a maximum cost ratio (5.30) and PPV (1083.66%), while sexagliptin 2.5 mg has minimal cost ratio (1.55) and PPV (55.08%). Among SGLT2i, dapagliflozin 5 mg had the highest cost ratio (10.79) and PPV (978.79%) and remogliflozin100 mg had the lowest cost ratio (1.57) and PPV (56.94%) and among combinations dapagliflozin 10 mg+ metformin 500 mg has the highest cost ratio (6.66) and PPV (565.75%), while empagliflozin 12.5 mg + metformin 500 mg has the lowest cost ratio (1.04) and PPV (4.00%). Current study shows large differences in cost ratio as well as PPV between brands. To reduce the financial burden and treatment adherence, physicians must prescribe less expensive drugs. Keywords: Cost analysis, Cost ratio, Percentage of price variation, Diabetes mellitus
Evaluation of Anthelmintic Activities of Persea americana and Musa sikkimensis
Authors:   Himalayan Pharmacy Institute, Majhitar, 737136, Sikkim, India, Sarmah Nihar Ranjan , Gupta Preety Rani , Sharma Raksha , Moktan Tashi Narbu , Bhattacharjee Ananya
Published: October 2024

The goal was to know about the anthelmintic properties of the leaves of P. americana and peels of M. sikkimensis. An ethanolic extract from the leaves of P. americana and aqueous extract of M. sikkimensis was used to screen for phytochemicals and analyse the anthelmintic activity on Indian earthworm Pheretima posthuma to determine its therapeutic capabilities. The experiment was carried out by preparing standard drug solution (Albendazole), P. americana leaf extract and M. sikkimensis peel extract in a concentration range of 5mg/ml, 10mg/ml and 20mg/ml respectively for each. The earthworms were placed in a beaker with solutions of varying concentrations. The time of paralysis and death was noted and plotted in a graph. From the results, it was found that P. americana and M. sikkimensis extract caused paralysis in less time in a dose-dependent manner, as well as the death was caused much earlier compared to the control group. This suggests that P. americana and M. sikkimensis extract exhibited strong anthelmintic activity. Furthermore, a link has been found between anthelmintic activity and high levels of flavonoids, terpenoids and tannins. Flavonoids, tannins and terpenoids found in various extracts have been proven to have anthelmintic properties in earlier investigations. Persea americana have been reported to have alkaloids, flavonoids, glycosides, saponins, steroids, tannins, proteins, and Musa sikkimensis have been reported to have alkaloids, glycosides, saponins, steroids, terpenoids, tannins, proteins. These results lead to the conclusion that P. americana and M. sikkimensis extract may possess anthelmintic activity. Keywords: Anthelmintic activity, Helminth, Musa, Avocado
“Tem mais presença em mim o que me falta”: a política para o Novo Ensino Médio e o cotidiano de três escolas públicas da rede estadual da Paraíba
Authors: Rodrigues Ana Cláudia da Silva , Alves Miriam Fábia , Süssekind Maria Luiza
Published: October 2024

Com o intuito de contribuir para as discussões acerca da Política Curricular do “novo” Ensino Médio, objetivamos apresentar reflexões sobre a pesquisa que desenvolvemos a fim de compreender como os praticantespensantes de instituições que ofertam essa etapa de ensino subvertemconstroem seus processos curriculares e criam/recriam/compartilham conhecimentossignificações em instituições da rede estadual da Paraíba. Metodologicamente, operamos com os cotidianos como “espaçotempo de produção/criação/invenção de conhecimentos – e de currículos” (Oliveira; Süssekind, 2017, p. 1) e enredamos, por meio das conversas complicadas (Pinar, 2007; 2016; 2017), os saberes produzidos e desconsiderados pelas políticas curriculares. Destacamos que esses conhecimentos vão muito além das prescrições de conteúdos, são tecidos no âmbito das experiências possíveis, nas atitudes e ações de professores e estudantes que dão existência a um currículo criado no chão da escola. Essas tessituras entre fios (conversas) e nós (políticas curriculares) se convertem em tramas que representam as resistências necessárias, pois transgridem as imposições dos conteúdosdisciplinasgrades (Süssekind, Gomes, Cavalcante, Tkotz, 2023) e possibilitam outros enlaces presentes nas universidades-escolas e que faltam à política para o “novo” Ensino Médio.
Recurso didático-pedagógico na Educação Ambiental: potencialidades dos fanzines para problematização das questões socioambientais
Authors: Fernandes Ana Luiza Borges da Costa , Pinto Benjamin Carvalho Teixeira , Vieira Bruno Matos , Teixeira Rafaela Pontes , Martins Alessandra da Silva Coelho
Published: October 2024

O objetivo deste estudo foi analisar o potencial do uso de fanzines como recurso didático-pedagógico na problematização das questões socioambientais, com ênfase na Educação Ambiental crítica. O trabalho caracteriza-se como uma pesquisa de observação participante, de caráter qualitativo, e foi desenvolvido com os alunos do 7° e 9° ano (em 2022); e com alunos do 6° e 7° ano (em 2023) do ensino fundamental, em duas escolas municipais de Seropédica, baixada fluminense do Rio de Janeiro. Para o desenvolvimento do trabalho, foram realizadas saídas de campo para mapear problemas socioambientais (situações-problemas) com paradas em dois pontos próximos das escolas e outros três pontos na Unidade de Conservação Flona Mário Xavier (onde seus limites também são próximos das duas escolas). Oitenta e seis estudantes participaram da pesquisa e foram produzidos 56 fanzines. Por meio da análise dos fanzines produzidos pelos alunos, identificou-se aprendizagem ativa, inclusiva, visão integrada, criativa e crítica da relação ser humano e o meio ambiente. Constatou-se que, ao longo das atividades, mapeamento das situações-problemas no campo e a prática dos fanzines possibilitou a produção de zines em uma perspectiva ecológica, histórica, social e política. Além disso, foi possível observar que o recurso didático-pedagógico dos fanzines auxiliou no desenvolvimento de habilidades como: o grau de compreensão do aluno acerca do tema, capacidade de síntese e planejamento do roteiro, desenvolvimento da escrita e expressão artística e estímulo à criatividade.
Romantic Jealousy: A Comprehensive Review
Authors: Karakoçoğlu Nazlı , Hasdağ Derya
Published: October 2024

Jealousy in a romantic relationship can have destructive consequences, such as ending relationships and leading to violent behaviors. Despite being heavily studied internationally for nearly three decades, it has not received sufficient attention in Turkish psychology literature. From this point of view, this article aims to address romantic jealousy from various perspectives, with the intention of providing ideas for future studies on the subject. The article discusses jealousy in a romantic relationship, taking various theoretical explanations into account to understand its triggers and forms of expression. It also includes the findings of various studies on jealousy in the international and Turkish literature. Finally, the article provides application and research suggestions based on the information obtained. According to the results of the reviewed studies, although jealousy is a universal emotion, there are intercultural differences in the experience of jealousy. As demonstrated by the reviewed studies, further research is necessary in both international literature and Türkiye to fully comprehend the dynamics of romantic jealousy and prevent its destructive consequences.
Immersion Programs: Beyond Language Learning
Authors: Rodriguez Ilba yaneth , Martínez Rodríguez Juan Esteban , Martínez Rodríguez Andrés Santiago
Published: October 2024

This research article is the result of a Project developed in a private school in Tunja, Colombia. It aimed at describing the perceptions of a group of graduates, students, and their parents about an immersion program, after having participated in one of them. Four surveys were applied to four different groups of participants: parents, graduates, students who traveled in 2018 and students who participated in the immersion program in 2019. After conducting the corresponding analysis, following the thematic approach, the perceptions presented by the participants were grouped into the following categories: Immersion programs: beyond learning a language; Knowing me and growing as a person, and My experience as a base to strengthen the program and my own school. It was possible to conclude that he immersion program had academic and social effects on the participants. It can be seen as a resource for learning, practicing, and reinforcing a foreign language as well as learning about other cultures.
Analisis de la satisfacion de los usuarios en la programacion de procedimientos quirugicos en una IPS de I nivel de Fusagasuga
Authors: Vasquez Gutierrez Delly Cecilia , Barragán Rodríguez Wilson Gabriel
Published: October 2024

El Sistema Obligatorio de Garantía de Calidad en Salud, (SOGS), como parte integral del Sistema General de Seguridad en Salud, (SGSSS) y contempla una atención con un mínimo de atributos, sin importar el tipo de vinculación.
La calidad está relacionada con las percepciones de cada individuo sobre el servicio de salud recibido dentro de unos estándares en los cuales las necesidades y las expectativas del usuario y del sistema influyen directamente en esta definición.
Las fallas detectadas y que afectan algunos de los atributos de la calidad, se manifiestan de múltiples maneras: servicios inefectivos e ineficientes; acceso limitado a los servicios; incremento de costos; quejas médicas; insatisfacción de los usuarios y de los profesionales; afectación de la credibilidad de los servicios, y lo más oneroso, en pérdidas humanas.
La medición de la satisfacción de los usuarios es un mecanismo que permite a los diferentes actores del SGSSS, pero de manera directa a las instituciones prestadoras de servicios de salud, implementar planes de mejora que les permitan ajustar los procesos deficitarios y de esta forma lograr altos estándares de calidad. La satisfacción del usuario en el proceso de programación de cirugía de forma ambulatoria, para el caso que nos ocupa, permite que la institución ajuste procesos con la única finalidad de lograr mitigar los riesgos disminuyendo la ocurrencia de eventos adversos y complicaciones, que permitan la excelencia en la prestación de servicios y por ende tener usuarios satisfechos
Conceição e “a explosão do Sol”
Authors: Manzano Marcelo
Published: October 2024

Texto em homenagem à economista Maria da Conceição Tavares, falecida em 8 de junho de 2024. Os breves comentários destacam sua contribuição para o embasamento teórico de estudos sobre a organização e a dinâmica do mercado de trabalho no Brasil, com foco em particularidades da formação de uma estrutura industrial avançada em uma economia dependente e periférica, assim como no legado de uma estrutura social heterogênea ainda muito marcada pela miséria crônica de grande parcela da população. Também destacam seu compromisso inabalável com a luta política pela transformação da realidade econômica e social do país.
Yapay Zekâ Destekli Peyzaj Tasarımında Müziğin Etkisi
Authors: Sağlık Alper , Yetişir Fatma
Published: October 2024

Müzik, insanlık tarihi boyunca varlığını sürdüren benzersiz bir olgu olup, dili ve alfabesi bilinmeden de anlaşılabilir ve her din, dil ve ırktan insanı bir araya getiren evrensel bir ifade biçimidir. Müziğin evrensel iletişim gücüne paralel olarak, peyzaj tasarımı da çevresel uyum ve estetik anlayışıyla insanları bir araya getirerek yaşanabilir mekânlar oluşturur. Peyzaj tasarımı, çevreyle uyumlu, estetik ve sürdürülebilir mekânlar oluşturmayı amaçlayan, sanatsal ilkeleri ve peyzaj elemanlarını kullanarak mekânları yenileme veya yeni mekânlar oluşturma sürecidir. Bu önemli iki kavram birbiriyle ilişkilendirilerek yapay zekâ yardımıyla bir ürün ortaya çıkarılmaya çalışılmıştır. Yapay zekâ, insanlar tarafından oluşturulan, bilim ve teknolojinin birleşimini temsil eden ve doğal zekayı simüle etmek için yapılan çalışmaların tümüdür. Bu çalışma, farklı müzik türlerinin hissettirdiği duygular ve oluşturdukları ortamların ‘ChatGPT’ ve ‘LookX AI Cloud’ yapay zekâ araçları kullanılarak nasıl görselleştirilebileceğini incelemektedir. Araştırmada, seçilen müzik türleri üç ana kategoriye ayrılarak her biri kendi içinde farklı dallara ayrılmıştır. Bu seçilen müzik türleri ve şarkılar, sözleri, tonlamaları, ritimleri, ses frekansları ve algı değerleri temelinde değerlendirilmiştir. Çalışma, her müzik türünün peyzaj tasarım unsurlarında farklılıklar yarattığını ortaya koymaktadır. Şekil, biçim, form, renk ve doku gibi tasarım öğelerinin her müzik türüne göre değişiklik gösterdiği gözlemlenmiştir.
Foreign Direct Investment and Its Effect on Agricultural Productivity Kenya
Authors: Wabwile Innocent , Abdillahi  Ali Umulkher , Simiyu Edwin Jairus , Ngala Consolata
Published: October 2024

Kenya has historically been one of Africa's top destinations for foreign direct investment. Foreign direct investment is critical for Kenya's agricultural sector, offering capital, technology transfer, and skill development that enhance productivity and economic growth. Despite agriculture being a primary economic driver, challenges such as limited capital, outdated farming techniques, and insufficient infrastructure continue to hinder growth. The research explores the contribution of foreign direct investment on agricultural productivity in Kenya as well as to assess the effect of foreign direct investment on the productivity levels of small-scale and large-scale farmers in Kenya for a period 1993 to 2022. Neoclassical growth theory, Endogenous theory were key in guiding the study. This study adapted the causal research design employing time series data from World Bank spanning from years 1993 to 2022. Data was analyzed the data both descriptively and by inferential statistics. The findings of correlational analysis revealed a moderate positive relationships (r= 0.3213) between Foreign direct investment and agricultural productivity. Multiple regression analysis confirmed the significant positive effect of foreign direct investment on agricultural productivity with a coefficient of 0.3661 and p value 0.0014<0.05. This signifies that, in the short term, a 1% increase in foreign direct investment results in a 36.61% rise in the growth of Agricultural productivity, assuming all other variables remain constant. The findings implied that foreign direct investment inflow has the ability to create employment, technological development and improve access to international markets playing a pivotal role in accelerating the agricultural productivity. The Kenyan government should have more effective foreign direct investment strategies to facilitate technology transfer agreements between foreign investors and local agricultural enterprises, additionally, the government should pursue macroeconomic policies that attract foreign direct investment by providing an investor-friendly environment.
Intensity and Determinants of Rural Migrant Workers’ Multidimensional Poverty in China
Authors: Xu Dan , Luo Dongshen , He Xiu , Lin Tingting , Wang Chengchao
Published: October 2024

Multidimensional poverty of rural migrant workers is become an important component of urban poverty of China, accompanied by large-scale rural-urban migration during past decades. However, less studies have been conducted to explore the poverty of rural-urban migrant workers. The study intends to fill the gap by investigating multidimensional poverty of rural migrant workers based on a case study in Fuzhou City, Southeast China. The Alkire–Foster method and a logistic regression modeling are adopted to examine the magnitude and determinants of multidimensional poverty. Four dimensions and ten indicators are selected for measurements of multidimensional poverty. About seventy three percent of the sample households (n=319) are found to experience multidimensional poverty, which is remarkably higher than previous studies. Especially, the deprivation incidence of dwelling conditions and working conditions which were neglected in previous studies, was remarkable high. Spatial heterogeneity of multidimensional poverty has been highlighted in our study. The incidence of multidimensional poverty in 'village in the city' is the highest, following by suburban areas and town center (k=0.33). Results also reveal that income and living standards are two most important contributors of overall poverty. The important determinants of multidimensional poverty are as follows: occupational skills, migration type, occupational type, social integration, and expenditure on social activities. The results confirmed that low skills, low social integration in cities, and poor social capital are key determinants of rural migrant workers’ poverty in urban areas of China. Finally, some policy implications for poverty alleviation of rural migrant workers are presented in the study.
From complexity to clarity: development of CHM-FIEFP for predicting effective components in Chinese herbal formulas by using big data
Authors: Pan Boyu , Zhu Han , Yang Jiaqi , Wang Liangjiao , Chen Zizhen , Ma Jian , Zhang Bo , Pan Zhanyu , Ying Guoguang , Li Shao , Liu Liren
Published: October 2024

Objective: The presence of complex components in Chinese herbal medicine (CHM) hinders identification of the primary active substances and understanding of pharmacological principles. This study was aimed at developing a big-data-based, knowledge-driven in silico algorithm for predicting central components in complex CHM formulas. Methods: Network pharmacology (TCMSP) and clinical (GEO) databases were searched to retrieve gene targets corresponding to the formula ingredients, herbal components, and specific disease being treated. Intersections were determined to obtain disease-specific core targets, which underwent further GO and KEGG enrichment analyses to generate non-redundant biological processes and molecular targets for the formula and each component. The ratios of the numbers of biological and molecular events associated with a component were calculated with a formula, and entropy weighting was performed to obtain a fitting score to facilitate ranking and improve identification of the key components. The established method was tested on the traditional CHM formula Danggui Sini Decoction (DSD) for gastric cancer. Finally, the effects of the predicted critical component were experimentally validated in gastric cancer cells. Results: An algorithm called Chinese Herb Medicine-Formula vs. Ingredients Efficacy Fitting & Prediction (CHM-FIEFP) was developed. Ferulic acid was identified as having the highest fitting score among all tested DSD components. The pharmacological effects of ferulic acid alone were similar to those of DSD. Conclusions: CHM-FIEFP is a promising in silico method for identifying pharmacological components of CHM formulas with activity against specific diseases. This approach may also be practical for solving other similarly complex problems. The algorithm is available at http://chm-fiefp.net/.
Myo-Inositol and Its Derivatives: Their Role in the Challenges of Infertility
Authors: Placidi Martina , Casoli Giovanni , Tatone Carla , Di Emidio Giovanna , Bevilacqua Arturo
Published: October 2024

Myo-inositol (MYO) and D-chiro-inositol (DCI) are the two most significant isomeric forms of inositol, playing a critical role in intracellular signaling. MYO is the most abundant form of inositol in nature; DCI is produced from MYO through epimerization by an insulin-dependent enzyme. Recently, it has been demonstrated that inositols may influence oocyte maturation, improve intracellular Ca2+ oscillation in the oocytes and have been proposed as potential interventions for restoring spontaneous ovulation. MYO concentration in human follicular fluid is considered a bioindicator of oocyte quality. In the ovary, DCI modulates the activity of aromatase thus regulating androgen synthesis. Under physiological conditions, MYO/DCI ratio is maintained at 40:1 in the plasma. In women with PCOS, MYO/DCI ratio lowers to 0:2:1, contributing to elevated androgen production. By regulating FSH signaling, MYO administration increases the number of high-quality embryos available for transfer in poor responder patients. Finally, by acting downstream to insulin signaling inositol administration during pregnancy may represent a novel strategy for counteracting gestational diabetes. These findings show that diet supplementation with inositols may be a promising strategy to address female infertility and sustain healthy pregnancy.
The Effect of Flaxseed Supplementation on Sex Hormone Profile in Adults: A Meta-Analysis
Authors: Abbasi Mohammad , Askari Ali , Azizi Atefeh , Jabbari Ghasem , Aghamohamadi Navid , Javidan Ashghar , Dindar Maryam , Asadi Alireza
Published: October 2024

Flaxseed has been suggested as a viable solution to improve sex hormones. However, conflicting and uncertain evidence regarding its impact on sex hormone profiles exists. This meta-analysis assesses the effects of flaxseed on sex hormone profiles. PubMed, Scopus, Embase, and the Web of Science were searched for relevant articles in August 2021. The Cochrane Collaboration tool was used for the quality assessment, and the evidence's trustworthiness was assessed using the Grading of Assessment, Development, and Evaluation of Recommendations (GRADE). A total of ten articles revealed that flaxseed might not have a significant effect on follicle-stimulating hormone (FSH) ((WMD: 0.84; 95% CI: -5.53, 7.00, p =0.791; I2= 88.6%, p<0.001, level of confidence: low), sex hormone-binding globulin (SHBG) ((WMD: 2.17; 95% CI: -1.19, 5.54, p =0.206; I2= 66.3%, p=0.011, level of confidence: low), total testosterone (TT) (WMD: -0.00; 95% CI: -0.07, 0.07, p=0.968; I2= 41.3%, p =0.146, level of confidence: low), free androgen index (FAI) (WMD: -0.13; 95% CI: -0.68, 0.42; p=0.645; I2= 85.4%, p<0.001, level of confidence: low) and dehydroepiandrosterone sulfate (DHEAS) (WMD: 0.62; 95% CI: -3.35, 4.59, p=0.761; I2=63.6%, p =0.064, level of confidence: very low). It is demonstrated that flaxseed might not affect sex hormones in adults. Flaxseed supplementation had no significant effect on sex hormones in adults. Nevertheless, due to the limited included trials, this topic is still open and needs further studies in future RCTs.
A Modern View of Placebo Interventions: From Comparative Clinical Trials to Novel Therapies to Quantum Tunnelling
Authors: Niazi Sarfaraz K
Published: October 2024

Placebo effects are acknowledged and no longer considered inert, as they can trigger neural and organic responses working through circuits involving the rostral anterior cingulate cortex, pontine nucleus, and cerebellum. Recent findings of quantum tunneling have expanded the possible functions of placebo interventions that may explain the rigidity of belief systems and functionality of homeopathy, opening a new chapter of the future of medicine, drawn from the prefrontal cortex, amygdala, anterior cingulate cortex, and striatum. The choice of current interventions, such as psychedelic substances, SSRIs, TMS, and DBS, can be expanded as our knowledge about the placebo intervention improves. At the same time, we need to understand the pros and cons of placebo-controlled clinical trials to ensure that stereotyped clinical trial designs do not hamper new drug development.
Hypopituitarism Associated with Non-Traumatic Subarachnoid Haemorrhage: A Narrative Review
Authors: Aljboor Ghaith S. , Radoi Mugurel Petrinel , Toader Corneliu , Covache-Busuioc Razvan Adrian , Papacocea Marius Toma
Published: October 2024

Background: Hypopituitarism is a potentially serious but often underdiagnosed condition that can occur following non-traumatic subarachnoid hemorrhage (SAH). The condition is characterized by the partial or complete deficiency of one or more pituitary hormones, leading to a range of clinical manifestations that may complicate the recovery process. This narrative review aims to synthesize the current literature on the prevalence, pathophysiology, and clinical implications of hypopituitarism associated with non-traumatic SAH. Methods: A comprehensive review of the literature was conducting by authors using databases such as PubMed, MEDLINE, and Scopus, focusing on studies published in the last two decades. Studies were selected based on their relevance to the topic, with an emphasis on those that reported on the prevalence, diagnostic approaches, pathophysiological mechanisms, and clinical outcomes of hypopituitarism post-SAH. Results: The review revealed a wide variability in the reported prevalence of hypopituitarism following non-traumatic SAH, ranging from 14% to 92.3%, depending on the diagnostic criteria, timing of assessment, and hormonal axes evaluated. Commonly affected hormones include growth hormone, gonadotropins, and cortisol. The pathophysiology of hypopituitarism in this context is multifactorial, involving ischemic damage, inflammation, and direct mechanical injury to the hypothalamic-pituitary axis. While some studies suggest a link between hypopituitarism and adverse clinical outcomes, the evidence remain inconclusive, highlighting the need for standardized diagnostic protocols and longitudinal studies. Conclusion: Hypopituitarism is a prevalent but often overlooked complication of non-traumatic SAH, with significant potential implications for long-term health outcomes. Routine endocrine evaluation and management of pituitary deficiencies are recommended to improve patient care. Future research should focus on refining diagnostic criteria, elucidating the underlying mechanisms, and evaluating the long-term impact of hormone replacement therapy in this patient population.
AI-Driven 5G Network Optimization: A Comprehensive Review of Resource Allocation, Traffic Management, and Dynamic Network Slicing
Authors: Bikkasani Dileesh chandra
Published: October 2024

The rapid advancement of 5G networks, coupled with the increasing complexity of resource management, traffic handling, and dynamic service demands, has underscored the need for more intelligent network optimization techniques. This paper comprehensively reviews AI-driven methods applied to 5G network optimization, focusing on resource allocation, traffic management, and network slicing. Traditional models face limitations in adapting to the dynamic nature of modern telecommunications, and AI techniques-especially machine learning (ML) and deep reinforcement learning (DRL)-offer scalable, adaptive solutions. These approaches enable real-time optimization by learning from network conditions, predicting traffic patterns, and intelligently managing resources across virtual network slices. AI's integration into 5G networks enhances performance, reduces latency, and ensures efficient bandwidth utilization. It is indispensable for handling the demands of emerging applications such as IoT, autonomous systems, and augmented reality. This paper highlights key AI techniques, their application to 5G challenges, and their potential to drive future innovations in network management, laying the groundwork for autonomous network operations in 6G and beyond.
Study of the Protein STK24 in Acute Myeloid Leukemia Using Bioinformatic Tools and Applications
Authors: Boro Arthi , Balamuralikrishnan Balasubramanian , Shanmugam Ramya , Sumithra Alagarsamy , Gavaskar Shanmugam , Umera Begam Ahame Kabeer , Pallavi Pragya , Arumugam Vijaya Anand
Published: October 2024

Acute myeloid leukemia (AML) is a severe blood cancer in myeloid cells which is found to be developed due to mutation in genes that causes dysregulation in the gene’s expression, affecting the cellular function and signaling pathways. STK24 is a protein belonging to the Germinal Center Kinase III (GCK III) sub-family, found to be related to many intracellular and intercellular processes. In the following study the expression of the gene STK24 is studied using the web-based tool TNM plot, in which the expression is found dysregulated in AML with a significant p-value of 9.76e - 23. In addition to expression analysis, survival analysis is carried out, the dysregulated expression of STK24 is found to be related to lower overall survivable outcome indicated by significant p-value of 1.6e - 05 with median survival for lower expression of the STK24 for 10.7 month time. In the protein-protein interaction analysis, the targeted protein STK24 was found to interact with several proteins, among them some of the proteins which are found to be related to AML pathogenesis are PDCD10, PPP2R1B, STK11, TCP1, STK25, STK26 and STRN3 with combined score between .5 to 1.00. Among the interacting proteins 20 proteins are found to have higher interaction efficiency which is represented in circular format. A correlation study of the target protein STK24 with AML and glutamine metabolism related protein FLT3, NPM1, RUNX1, RARA, IDH1, IDH2, GLS, SLC1A5, GLUD1 and SLC7A11 showed a significant correlation with Pearson’s coefficient r value between -1 to 1 and p-value < 0.05. With the analysis of expression and survival and protein-protein interaction and gene correlation it can be indicated that STK24 may have a role in pathogenesis in AML. But to conclude the study, further expression of the gene STK24 in the AML is needed to prove its correlation with the disease progression and further in vitro and in vivo analysis are needed to be carried out.
Tutorial Generation For Virtual Reality from Example Playtroughs
Authors: Safikhani Saeed , Lux Dorian , Schmalstieg Dieter , Pirker Johanna
Published: October 2024

As virtual reality (VR) games appeal to increasingly large audiences, many newcomers need convenient and flexible onboarding sessions. Traditional methods of creating tutorial levels can be time-consuming and require additional effort from the development team. In this paper, we present a toolkit for computer-assisted tutorial generation in VR. We conducted an interview with developers and a between-subjects user study to evaluate our toolkit compared to a manually designed onboarding experience by measuring user performance in actual gameplay. The results indicate that our toolkit performs equivalently to manual tutorials in terms of user success. Most users subjectively prefer a manually designed tutorial primarily for its aesthetic value. These results are encouraging, as they prove the feasibility of semi-automated onboarding.
Incorporating Indigenous Knowledge Systems into AI Governance: Enhancing Ethical Frameworks with Maori and Navajo Perspectives
Authors: Ray Shawn
Published: October 2024

This paper proposes a paradigm shift in AI governance by integrating Indigenous knowledge systems to foster inclusivity and cultural sensitivity. Traditional AI governance frameworks are primarily Western-centric, often overlooking the community-oriented values and ethical considerations essential to Indigenous cultures. This study highlights principles such as Kaitiakitanga from Māori culture, which emphasizes guardianship and environmental stewardship, and Hózhó from Navajo philosophy, which stresses harmony and balance. By engaging Indigenous leaders and knowledge holders throughout the AI lifecycle, this approach ensures technology aligns with community values, addressing critical issues like data sovereignty, ethical technology use, and cultural sensitivity. This paper underscores the necessity of relational accountability in AI governance, which includes prioritizing the health of ecosystems alongside community welfare. This model advocates for an AI framework that not only rectifies historical marginalization but also empowers Indigenous communities to shape the technologies affecting their lives. Furthermore, integrating Indigenous perspectives strengthens the ethical foundation of AI systems, advancing sustainability, social justice, and cultural responsiveness in technology applications. The proposed framework illustrates how Indigenous ethical concepts can transform AI governance by aligning technological progress with values of ecological stewardship and community welfare, creating an AI landscape that respects and reflects diverse cultural contexts. Ultimately, this research demonstrates that Indigenous knowledge systems can significantly enhance AI’s effectiveness and equity, paving the way for more sustainable and culturally attuned technological solutions.
Asymmetric Roles of Different Punishments under Centralized Sanctions
Authors: Ziying Zhang , Elvis Nguepi Tsafack , Gonglin Hou , Yan Kang Chun , Yun Shen Yun
Published: October 2024

Altruistic punishment has been found to promote cooperation and address social dilemmas in both small and large societies. For many years, peer punishment has been viewed as a decentralized sanction to promote cooperation. Recent studies have found that centralized sanctions and punishments are more effective. In this paper, we incorporate centralized sanctions (third-party sanctions) into the repeating public goods game to investigate how different patterns of third-party punishment impact public cooperation and the organization’s profit, given enough information. Furthermore, the study assesses the influence of various punishments on cooperative behavior and examines the asymmetric roles of punishments in centralized sanctions. As a result: (1) Given enough information, high-intensity and non-random punishment can maintain long-term and high-level cooperation. (2) Punishment successfully deters free riding, regardless of intensity or randomness. (3) Under punishment, people can swiftly establish cooperative social norms to avoid punishment and, eventually, increase profits, regardless of the pattern applied. Therefore, our study sheds light on the heterogeneity of human cooperative behaviors under different centralized sanctions and proves the effectiveness of punishment in promoting human cooperation.
Determining the Physical Value of Human Transport Services: A Proposal for a Sensor-Based Approach
Authors: Müller J Gerhard
Published: October 2024

The paper is concerned with the problem of assigning value to a transport service that moves a mass M with velocity vAB in a time τAB from a first point A to a more distant point B. It is argued that the value of such a transport service can be measured in an objective and physically accessible way by calculating the physical action WAB(M,vAB,τAB) upon moving a mass M along a specific path joining points A and B. In the specific case of a linear straight-line motion in a force-free field this action attains a minimum value of WAB_ideal= 12MvAB2τAB=12MvABLAB which shows that the function WAB_ideal(M,LAB,τAB) contains all those quantities which in practice determine the money-value of the related transport service. It is argued that with the sensor hardware routinely available in modern cars, the accumulation of transport value with driving can be continuously monitored inside a car. Such accumulation allows the transport value gained at the final destination B to be compared to the intrinsic value of a transport service that connects points A and B. In this way, the potential for optimizing transport services with regard to economic and ecological constraints can be quantitatively assessed and possible improvements be identified.
The Association of Socioeconomic Status (SES) with Procedural Management and Mortality After Percutaneous Coronary Intervention (PCI): An Observational Study from the Pan-London PCI (BCIS) Registry
Authors: Rathod Krishnaraj S. , Lim Pitt , Firoozi Sam , Bogle Richard , Jain Ajay , MacCarthy Philip A. , Dalby Miles , Malik Iqbal S. , Mathur Anthony , Spratt James C , De Silva Ranil , Rakhit Roby , Hill Jonathan , Kalra Sundeep Singh , Redwood Simon , Archbold R. Andrew , Wragg Andrew , Jones Daniel A.
Published: October 2024

Background:Lower socioeconomic status (SES) has been associated with increased mortality from coronary heart disease. This excess risk, relative to affluent patients, may be due to a combination of more adverse cardiovascular‐risk factors, inequalities in access to cardiac investigations, longer waiting times for cardiac revascularisation and lower use of secondary prevention drugs. We sought to investigate whether socio-economic status influenced long-term all-cause mortality after PCI in a large metropolitan city (London), which serves a population of 11 million people with a mixed social background over a 10-year period. Methods: We conducted an observational cohort study of 123,780 consecutive PCI procedures from the Pan-London (United Kingdom) PCI registry. This data set is collected prospectively and includes all patients treated between January 2005 to December 2015. The database includes PCI performed for stable angina and ACS (ST-elevation myocardial infarction (STEMI), non-ST elevation myocardial infarction (NSTEMI) and unstable angina). Patient socio-economic status was defined by the English Index of Multiple Deprivation (IMD) score, according to residential postcode. Patients were analysed by quintile of IMD score (Q1, least deprived; Q5, most deprived). Median follow-up was 3.7 (IQR: 2.0-5.1) years and the primary outcome was all-cause mortality. Results: The mean age of the patients was 64.3±12.1 years and 25.2% were female. 22.4% of patients were diabetic and 27.3% had a history of previous myocardial infarction. The rates of long-term all-cause mortality increased progressively across quintiles of IMD score, with patients in Q5 showing significantly higher long-term mortality rates compared with patients in Q1 (p=0.0044). This persisted following the inclusion of a propensity score in the proportional hazard model as a covariate (HR for Q5 compared to Q1: 1.15 [95% CI: 1.10-1.42]). Conclusion: This study has demonstrated that low SES is an independent predictor of adverse clinical outcomes following PCI for in a large diverse metropolitan city of London. Hence, attention to reduce the burden of cardiovascular risk factors and improve primary prevention, particularly in patients with lower SES, is required.