bluuebunny/crossref_metadata_2025 huggingface dataset:
Are Expensive Expressways in China Attractive to Businesses? Evidence From the Location Selections of Manufacturing Enterprises
Authors: Wang Xuheng , Lin Ruofei , Ye Wei , Ma Zhongmei
Published: November 2022

Most expressways in China are tolled, making expressway transportation expensive for enterprises. Traditional location theory focuses only on transportation distances and transit costs, making it difficult to explain how expressways influence location decisions of enterprises. This research starts from the perspective of expressway travel times to explain how tolled expressways affect the location choices of new manufacturing enterprises. A geographic information system digital map of expressways for the years 2000–2013 was developed. The origin–destination matrix module was used to calculate the expressway travel times of 293 cities. Count data regression models, including probit, Poisson, zero-inflated Poisson, and negative binomial regression, were applied to empirically study the influence of expressway construction on the location selections of new manufacturing enterprises. The results show that reduced expressway travel time significantly attracts new enterprises and positively affects the location selections of manufacturing enterprises in China. Further, this finding reveals significant heterogeneity across different manufacturing industries.
A Dynamic Analysis of Women’s Labour Force Participation in Urban India
Authors: Menon Rahul , Nath Paaritosh
Published: November 2022

The introduction of the Periodic Labour Force Survey (PLFS) heralded a methodological innovation for the study of Indian labour, allowing the researcher to build panels tracking urban individuals over a year. Using two rounds of the PLFS covering the periods 2017–18 and 2018–19, we construct a pooled panel of urban Indian individuals aged 15–65 and focus on women’s experiences in the labour force. We find evidence of low dynamism in the Indian economy, with women facing significant difficulties regarding labour force participation. While a majority of women remain outside the labour force throughout the year, those who do participate face significant disadvantages. Job-finding rates for women are half that of men, indicating weak demand for women’s labour in the economy. Women face significant exits from both employment and unemployment, with nearly 18% of employed women leaving their jobs and moving to non-participation over the year. Women’s relative disadvantages persist even when age and education are considered, with the lowest job-finding rates seen for young and graduate women, and rates of labour force exit much higher than that of men. This paper highlights the importance of looking at demand side questions when it comes to examining women’s labour force participation.
Associations Between Human Papillomavirus Vaccine Decisions and Exposure to Vaccine Information in Social Media
Authors: Llavona-Ortiz Josheili Y. , Spanos Katherine E. , Kraschnewski Jennifer L. , D’Souza Gail , Myrick Jessica Gall , Sznajder Kristin K. , Calo William A.
Published: November 2022

Purpose

Exposure to different types of vaccine information in social media can result in parents making disparate vaccine decisions, including not following national guidelines for human papillomavirus (HPV) vaccination. We sought to characterize parents’ exposure to and engagement with information about HPV vaccination in social media, and the associations between exposure to such information and vaccine decisions for their adolescent children.

Methods

In 2019, we conducted a web-based survey with a national sample of 1073 parents of adolescents who use social media. The survey assessed whether parents have seen information in favor, against, or mixed about HPV vaccination. Multivariable logistic regressions assessed correlates of vaccine decisions, including HPV vaccine initiation, delay, and refusal.

Results

Sixty-one percent of parents reported that their children have initiated HPV vaccination. Over one-third of parents (37%) reported seeing HPV vaccine information on social media, which was either in favor (20%), against (5%), or a mix (12%). Parents exposed to information in favor were more likely than those who saw no information to have initiated HPV vaccination (OR = 1.74, 95% CI:1.24, 2.44). Parents exposed to information against vaccination were more likely to have delayed (OR = 3.29, 95% CI:1.66, 6.51) or refused (OR = 4.72, 95% CI:2.35, 9.50) HPV vaccination. Exposure to mixed information was also significantly associated with vaccine delay and refusal.

Discussion

Our findings suggest that the type of information seen on social media regarding HPV vaccination may influence the decisions parents make about vaccinating their children. Efforts should be sought to increase online information in favor of HPV vaccination and combat vaccine misinformation in social media.
The Heritability of ADHD in Children of ADHD Parents: A Post-hoc Analysis of Longitudinal Data
Authors: Uchida Mai , DiSalvo Maura , Walsh Daniel , Biederman Joseph
Published: November 2022

Objective:

A growing literature suggests attention-deficit/hyperactivity disorder (ADHD) is a heritable disorder. We evaluated children at risk for ADHD by virtue of having parents with ADHD and compared them with children of parents without ADHD to assess the degree of heritability of ADHD.

Method:

The sample for this study was derived from three longitudinal studies that tracked families with various disorders, including ADHD. Children were stratified based on presence of parental ADHD, and clinical assessments were taken to evaluate presence of ADHD and related psychiatric and functional outcomes in children.

Results:

Children with parental ADHD had significantly more full or subthreshold psychiatric disorders (including ADHD) as well as functional impairments compared to children without parental ADHD.

Conclusion:

Our findings suggest that offspring of parents with ADHD are at significant risk for ADHD and its associated psychiatric, cognitive, and educational impairments. These findings aid in identifying early manifestations of ADHD in young children at risk.
Evaluation of the association between the internal carotid artery and vertebral artery tortuosity and acute ischemic stroke using tortuosity index
Authors: Aghasadeghi Firoozeh , Dehghan Alireza
Published: November 2022

Objective

To determine the association between the tortuosity of the internal carotid artery and vertebral artery and the occurrence of acute ischemic stroke based on a new quantitative method.

Methods

This retrospective case-control study was conducted on 63 patients diagnosed with acute ischemic stroke in the case group and 52 patients in the control group. All the participants underwent neck Computed Tomography Angiography. The images were retrospectively reviewed and the tortuosity index was measured for internal carotid and vertebral artery. Then, a multivariable binary logistic regression model adjusted for the potential confounders was performed to assess the independent effect of internal carotid/vertebral artery tortuosity on acute ischemic stroke.

Results

Analysis of the logistic regression model revealed a significant effect of the internal carotid artery tortuosity index on anterior territory infarction (odds ratio = 1.04, p = 0.01) as well as a significant effect of the vertebral artery tortuosity index on posterior territory infarction (odds ratio = 1.14, p < 0.001). The optimal cut-off points for the internal carotid and vertebral artery tortuosity were 16.91 and 22.96, respectively.

Conclusions

This study showed that tortuosity of extracranial portions of the internal carotid and vertebral artery could be an independent imaging predictor of acute ischemic stroke in anterior and posterior circulation territories, respectively.
What about fundamental rights? Security and fundamental rights in the midst of a rule of law breakdown
Authors: Saenz Perez Cristina
Published: November 2022

This article considers the balance between security and fundamental rights that characterises EU criminal law and examines how processes of rule of law backsliding have re-shaped it. Traditionally, EU criminal law has been characterised by its securitisation, which crystallised in the prioritisation of the principle of mutual trust over concerns for the rights of defendants. However, processes of rule of law breakdown at Member State level have challenged this balance and demonstrated the flawed foundations of mutual trust. This paper explores how the CJEU is addressing these contradictions through case law that, nonetheless, continues to prioritise security over the right to a fair trial, whilst Member State courts challenge these interpretations and develop decentralised interpretations of the right to a fair trial. The goal is to evaluate whether judicial dialogue provides an adequate framework to counter the securitisation of EU criminal law and protect the right to a fair trial in the midst of a process of rule of law breakdown.
Hip BMD is associated with visceral fat change: a registry study of osteoporosis and sarcopenia
Authors: Chen Ying-Chou , Wang Yu-Wei , Ko Chi-Hua , Chen Jia-Feng , Hsu Chung-Yuan , Yu Shan-Fu , Cheng Tien-Tsai
Published: November 2022

Background:

Osteoporosis increases the risk of fractures. Visceral fat is associated with cardiovascular disease (CVD). There is inadequate knowledge on the relationship between osteoporosis and visceral fat. The study aimed to evaluate the relationship between bone mineral density (BMD) and visceral fat mass in the elderly.

Methods:

This was a prospective cohort study. Subjects were enrolled from the Rheumatology Clinic. All subjects underwent baseline bone mineral density and body composition measurements using dual-energy X-ray absorptiometry.

Results:

A total of 321 patients including 288 females and 33 males were enrolled in this study. We followed up DEXA for 1 year for fat and muscle mass change and found that 162 (50.5%) had a decrease in fat mass, 129 (40.2%) had decreased visceral fat, and 138 (43%) had decreased muscle mass. Furthermore, we found that the baseline hip T score was correlated with visceral fat decrease. Using visceral fat decrease as the outcome, we found that hip T score could predict visceral fat loss: the higher the T score, the more visceral fat loss was found [ p < 0.001, OR: 1.6, CI: (1.3–2.1)].

Conclusion:

A high hip T score was associated with a future decrease in visceral fat, which may decrease the risk of atherosclerosis and CV risk. Therefore, evaluation of visceral fat may be useful for assessing CVD risk in patients with osteoporosis. Effective management of the risk of atherosclerosis and CVD is important in improving the life expectancy of these patients.
Magnitude and associated factors of respectful maternity care in Tirunesh Beijing Hospital, Addis Ababa, Ethiopia, 2021
Authors: Mingude Alemu Basazin , Dejene Tadesse Mamo , Habtegiorgis Samuel Derbie , Sahle Fiseha
Published: November 2022

Objective:

The main aim of this research was to assess the magnitude of respectful maternity care and associated factors during labour and delivery in Tirunesh Beijing General Hospital, 2021.

Methods:

Facility-based cross-sectional research was employed among 319 postnatal mothers who were selected by systematic random sampling technique. Bi-variable and multi-variable logistic regression analysis was used to identify associated factors. Variables whose p-value < 0.05 in the multivariable model with 95% confidence interval were considered as statically significant.

Results:

A total of 319 respondents participated in the research with a response rate of 100%. The overall prevalence of respectful maternity care was 87.8%. Type of delivery in which caesarean section (adjusted odds ratio = 10.4, 95% confidence interval: (1.8, 61) and spontaneous vaginal delivery (adjusted odds ratio = 2.9, 95% CI: 1.4, 6). Getting delivery service by the provider of their preference (adjusted odds ratio = 2.6, 95% CI: 1.3, 5.2), still birth (AOR = 5.8 95% CI: 1.3, 25.8) and sex of delivery attendant (adjusted odds ratio = 3.6, 95% CI: 1.8, 7.5) were associated factors RMC.

Conclusion and recommendation:

In our research area, a sizable number of women have received respectful maternity care, but abuse and disrespect are still complaints. Therefore, emphasis should be placed on respectful maternity care by every healthcare professional and health service manager.
A two-step process for in silico screening to assess the performance of qRTPCR kits against variant strains of SARS-CoV-2
Authors: Gupta Swati , Kumar Amit , Gupta Nivedita , Bharti Deepak R. , Aggarwal Neeraj , Ravi Vasanthapuram
Published: November 2022

Background

Since inception of the COVID-19 pandemic, early detection and isolation of positive cases is one of the key strategies to restrict disease transmission. Real time reverse transcription polymerase chain reaction (qRTPCR) has been the mainstay of diagnosis. Most of the qRTPCR kits were designed against the target genes of original strain of SARS-CoV-2. However, with the emergence of variant strains of SARS-CoV-2, sensitivity of the qRTPCR assays has reportedly reduced. In view of this, it is critical to continuously monitor the performance of the qRTPCR kits in the backdrop of variant strains of SARS-CoV-2. Real world monitoring of assay performance is challenging. Therefore, we developed a two-step in-silico screening process for evaluating the performance of various qRTPCR kits used in India.

Results

We analysed 73 qRT-PCR kits marketed in India, against the two SARS-CoV-2 VoCs. Sequences of both Delta (B.1.617.2) and Omicron (B.1.1.529) VoCs submitted to GISAID within a specific timeframe were downloaded, clustered to identify unique sequences and aligned with primer and probe sequences. Results were analysed following a two-step screening process. Out of 73 kits analysed, seven were unsatisfactory for detection of both Delta and Omicron VoCs, 10 were unsatisfactory for Delta VoC whereas 2 were unsatisfactory for only Omicron VoC.

Conclusion

Overall, we have developed a useful screening process for evaluating the performance of qRTPCR assays against Delta and Omicron VoCs of SARS-CoV-2 which can be used for detecting SARS-CoV-2 VoCs that may emerge in future and can also be redeployed for other evolving pathogens of public health importance.
A simple parasitological technique to increase detection of Strongyloides stercoralis in Bolivian primary health care system
Authors: Camacho-Alvarez Ivana , Chavez-Mamani Elia M. , Philippe Goyens , Luizaga-López Jenny M. , Torrico Mary Cruz , Gétaz Laurent , Jacobs Frédérique
Published: November 2022

Background

Strongyloides stercoralis is widespread; however, there is limited information on its prevalence owing to laboratory underestimation and low clinical manifestations. The Baermann method and agar culture stand out among the parasitological techniques. Strongyloides stercoralis is present in Bolivia, but its prevalence in children remains unknown. The objective of this study was to estimate the applicability of simple parasitological techniques to increase the detection of this parasite in children living in the tropics.

Methods

This cross-sectional study was conducted in a tropical village in Cochabamba, Bolivia. Participants were 304 children aged 5 – 12 years who provided stool samples for different parasitological analyses (direct examination, Ritchie, Baermann, and Dancescu techniques), and their parents provided informed consent.

Results

Up to 64.8% of pathogenic parasites were detected using the modified Ritchie method. The Baermann technique identified 17.8% of Strongyloides stercoralis cases, and a high sensitivity with respect to the Baermann technique was only for the Dancescu technique (75.9%) that is also specific for Strongyloides stercoralis, followed by 66.7% for the modified Ritchie technique, which is used in second-line care.

Discussion

The Baermann technique is the best parasitological option for improving Strongyloides stercoralis diagnosis in the first-line care of the Primary Health Care System. A particular cycle of reinfection, combined with the environment and some other risk factors are related with persistence. Control is difficult without a proper diagnosis, and the Baermann technique is an approach to the solution. We conclude that with a high suspicion of the presence of Strongyloides stercoralis, the use of the Baermann technique is strongly recommended as support for direct examination in primary health care systems especially in tropical areas.
Oropharyngeal swallowing physiology and safety in patients with Idiopathic Pulmonary Fibrosis: a consecutive descriptive case series
Authors: Alamer Amal , Jones Rhys , Drinnan Michael , Simpson A. John , Griffin Mike , Patterson Joanne M. , Althuwaybi Abdullah , Ward Chris , Forrest Ian A.
Published: November 2022

Introduction

Dysphagia occurs in multiple respiratory pathophysiologies, increasing the risk of pulmonary complications secondary to aspiration. Reflux associated aspiration and a dysregulated lung microbiome is implicated in Idiopathic Pulmonary Fibrosis (IPF), but swallowing dysfunction has not been described. We aimed to explore oropharyngeal swallowing in IPF patients, without known swallowing dysfunction.

Methods

Fourteen consecutive outpatients with a secure diagnosis of IPF were recruited and the 10-item Eating Assessment Tool (Eat 10) used to assess patient perception of swallowing difficulty. Oropharyngeal swallowing was assessed in ten patients using Videofluoroscopy Swallow Studies (VFSS). The studies were rated using validated scales: Penetration-Aspiration Scale (PAS); standardised Modified Barium Swallow Impairment Profile (MBSImP).

Results

EAT-10 scores indicated frank swallowing difficulty in 4/14 patients. Videofluoroscopy Studies showed that 3/10 patients had airway penetration, and one aspirated liquid without a cough response. Median MBSImp for oral impairment was 5, range [3–7] and pharyngeal impairment 4, range [1–14] indicating, overall mild alteration to swallowing physiology.

Conclusion

We conclude that people with IPF can show a range of swallowing dysfunction, including aspiration into an unprotected airway. To our knowledge, this is the first report on swallowing physiology and safety in IPF. We believe a proportion of this group may be at risk of aspiration. Further work is indicated to fully explore swallowing in this vulnerable group.
Predictive value of the TyG index and rheumatoid factor for cardiovascular disease risk in a rheumatoid arthritis population: data from a survey of 418 patients
Authors: Wang Zihan , Lan Tianyi , Zhang Liubo , Luo Jing , Wang Jinping , Li Lin , Tao Qingwen
Published: November 2022

Objective

To investigate the correlation between the triglyceride-glucose (TyG) index and rheumatoid factor levels and the existence of cardiovascular disease in patients in the rheumatoid arthritis population and to analyze their potential value in predicting the risk of cardiovascular disease.

Methods

Patients with rheumatoid arthritis treated by the Traditional Chinese Medicine Department of Rheumatism of the China-Japan Friendship Hospital from 2019–01 to 2021–12 were included in this retrospective study. Regression analysis was performed with multifactor-corrected multimodal logistic models to observe the correlation between the TyG index and rheumatoid factor and cardiovascular disease risk, construct predictive models and assess the potential predictive value of the variables on cardiovascular disease risk with receiver operating characteristic curves. The results were further corrected by sensitivity analysis and trend tests.

Results

A total of 418 patients with rheumatoid arthritis were included in the study. In the rheumatoid arthritis population, high rheumatoid factor (OR = 1.002, 95% CI = 1.001–1.002, P < 0.001), high TyG index (OR = 1.057, 95% CI = 1.008–1.109, P = 0.022), advanced age (OR = 1.080, 95% CI = 1.050–1.112, P < 0.001), and low physical activity (OR = 2.848, 95% CI = 1.195–6.785, P = 0.018) were independent risk factors for the existence of cardiovascular disease in patients. The combined coefficient calculated on the basis of the TyG index and rheumatoid factor was used to plot the receiver operating characteristic curve with an area under the curve of 0.791, which can be used to predict the potential risk of cardiovascular disease in patients with rheumatoid arthritis. Further sensitivity analysis found that the marker of focus remained associated with cardiovascular disease risk in a high-physical activity population with rheumatoid arthritis. The final trend test found a linear trend between the TyG index, rheumatoid factor levels and the risk of cardiovascular disease.

Conclusion

In the rheumatoid arthritis population, the TyG index and rheumatoid factor have some potential predictive value in determining the risk of cardiovascular disease, and the predictive efficacy is better when the two tests are combined.
Genotyping and biofilm formation of Mycoplasma hyopneumoniae and their association with virulence
Authors: Wu Yuzi , Yu Yanfei , Hua Lizhong , Wei Yanna , Gan Yuan , Chenia Hafizah Yousuf , Wang Yixuan , Xie Xing , Wang Jia , Liu Maojun , Shao Guoqing , Xiong Qiyan , Feng Zhixin
Published: November 2022

Mycoplasma hyopneumoniae, the causative agent of swine respiratory disease, demonstrates differences in virulence. However, factors associated with this variation remain unknown. We herein evaluated the association between differences in virulence and genotypes as well as phenotype (i.e., biofilm formation ability). Strains 168 L, RM48, XLW-2, and J show low virulence and strains 232, 7448, 7422, 168, NJ, and LH show high virulence, as determined through animal challenge experiments, complemented with in vitro tracheal mucosa infection tests. These 10 strains with known virulence were then subjected to classification via multilocus sequence typing (MLST) with three housekeeping genes, P146-based genotyping, and multilocus variable-number tandem-repeat analysis (MLVA) of 13 loci. MLST and P146-based genotyping identified 168, 168 L, NJ, and RM48 as the same type and clustered them in a single branch. MLVA assigned a different sequence type to each strain. Simpson’s index of diversity indicates a higher discriminatory ability for MLVA. However, no statistically significant correlation was found between genotypes and virulence. Furthermore, we investigated the correlation between virulence and biofilm formation ability. The strains showing high virulence demonstrate strong biofilm formation ability, while attenuated strains show low biofilm formation ability. Pearson correlation analysis revealed a significant positive correlation between biofilm formation ability and virulence. To conclude, there was no association between virulence and our genotyping data, but virulence was found to be significantly associated with the biofilm formation ability ofM. hyopneumoniae.
Endoscopic tympanoplasty type I using interlay technique
Authors: Takahashi Masahiro , Motegi Masaomi , Yamamoto Kazuhisa , Yamamoto Yutaka , Kojima Hiromi
Published: November 2022

Background

Tympanoplasty using the interlay technique has rarely been reported in transcanal endoscopic ear surgery, unlike the underlay technique. This is because many surgeons find it challenging to detach the epithelial layer of the tympanic membrane using only one hand. However, the epithelial layer can be easily detached from the inferior part of the tympanic membrane. Another key point is to actively improve anteroinferior visibility even if the overhang is slight because most perforations and postoperative reperforations are found in the anteroinferior quadrant of the tympanic membrane. We report the application of the interlay technique in endoscopic tympanoplasty type I for tympanic perforations.

Methods

We retrospectively reviewed the medical records of 51 patients who had undergone tympanoplasty using the interlay technique without ossiculoplasty between 2017 and 2020. We then compared the data with those of patients who underwent microscopic surgery (MS) using the underlay technique between 1998 and 2009 (n = 104). No other technique was used in each group during this period. Repair of tympanic membrane perforation and hearing outcomes were assessed for > 1 year postoperatively.

Results

The perforation sites were limited to the anterior, posterior, and anterior–posterior quadrants in 23, 1, and 27 ears, respectively. Perforations were closed in 50 of the 51 ears (98.0%), and the postoperative hearing was good (average air-bone [A-B] gap was 6.8 ± 5.8 dB). The surgical success rate for the repair of tympanic membrane perforation was not significantly different from the MS group (93.3%, P = 0.15). The average postoperative average A-B gap in the group that underwent the interlay technique was significantly different from that in the MS group (10.1 ± 6.6 dB, P < 0.01).

Conclusion

The interlay technique should be considered as one of the treatment methods in endoscopic surgery for tympanic perforations. Further study of the postoperative outcomes of this procedure should be conducted to establish the optimal surgical procedure for tympanic perforations. Trial registration: This study was retrospectively approved by the Institutional Review Board of the Jikei University, Tokyo, Japan (approval number: 32-205 10286).

Video abstract
Cold Crystallization in Mixed Systems of Alkyl-Derivatized Schiff-Base Nickel(II) Complexes
Authors: Ishikawa Toru , Honda Akinori , Miyamura Kazuo
Published: November 2022

To achieve cold crystallization for energy storage, alkyl-derivatized [[N,N′-bis-(2′,4′-dihydroxybenzylidene)]-1,2-diamino-2-methylpropanato] nickel(II) complexes (OCn-salmpn, n = 2, 4, 6, 8, 10, 12, 14, 16, and 18) were prepared. OC4-salmpn containing quaternary carbons with two methyl groups was mixed with OC12, 14-, 16-, and 18-salmpn in various amounts. Thermal analysis showed supercooling and heat storage phenomena, including ‘cold crystallization’, an exothermic phenomenon that occurs when supercooled liquids are heated, which is important for heat-storage materials. Notably, the individual components of the mixed samples did not exhibit cold crystallization. The supercooled state and cold crystallization were plausibly derived by combining the properties of OC4-salmpn, which only undergoes a glass transition after melting and does not crystallize, with those of OC12-, 14-, 16-, and 18-salmpn, which crystallize upon cooling, as is typical for these materials. To achieve cold crystallization, the mixing ratio must be optimal. The optimal mixing ratio depends on the alkyl chain length.
Responding to a rise in liver cancer
Authors: Hill Rebekah
Published: November 2022

Rebekah Hill welcomes the launch of Liver Cancer UK, part of the British Liver Trust, designed to improve the lives and outcomes of those affected by liver cancer
Modeling of Real Time Traffic Flow Monitoring System Using Deep Learning and Unmanned Aerial Vehicles
Authors: Upadhye Sachin , Neelakandan S. , Thangaraj K. , Babu D. Vijendra , Arulkumar N. , Qureshi Kashif
Published: November 2022

Recently, intelligent video surveillance technologies using unmanned aerial vehicles (UAVs) have been considerably increased in the transportation sector. Real time collection of traffic videos by the use of UAVs finds useful to monitor the traffic flow and road conditions. Since traffic jams have become common in urban areas, it is needed to design artificial intelligence (AI) based recognition techniques to attain effective traffic flow monitoring. Besides, the traffic flow monitoring system can assist the traffic managers to start efficient dispersal actions. Therefore, this study designs a real time traffic flow monitoring system using deep learning (DL) and UAVs, called RTTFM-DL. The proposed RTTFM-DL technique aims to detect vehicles, count vehicles, estimate speed and determine traffic flow. In addition, an efficient vehicle detection model is proposed by the use of Faster Regional Convolutional Neural Network (Faster RCNN) with Residual Network (ResNet). Also, a detection line based vehicle counting approach is designed, which is based on overlap ratio. Finally, traffic flow monitoring takes place based on the estimated vehicle count and vehicle speed. In order to guarantee the effectual performance of the RTTFM-DL technique, a series of experimental analyses take place and the results are examined under varying aspects. The experimental outcomes highlighted the betterment of the RTTFM-DL technique over the recent techniques. The RTTFM-DL technique has gained improved outcomes with a higher accuracy of 0.975.
Unveiling room temperature upconversion photoluminescence in monolayer WSe2
Authors: Mushtaq Aamir , Yang Xiaodong , Gao Jie
Published: November 2022

Upconversion photoluminescence (UPL) is a phenomenon describing an anti-Stokes process where the emitted photons have higher energy than the absorbed incident photons. Transition metal dichalcogenides (TMDCs) with strong photon-exciton interactions represent a fascinating platform for studying the anti-Stokes UPL process down to the monolayer thickness limit. Herein, we demonstrate room-temperature UPL emission in monolayer WSe2 with broadband near-infrared excitation. The measured excitation power dependence of UPL intensity at various upconversion energy gains unveils two distinguished upconversion mechanisms, including the one-photon involved multiphonon-assisted UPL process and the two-photon absorption (TPA) induced UPL process. In the phonon-assisted UPL regime, the observed exponential decay of UPL intensity with the increased energy gain is attributed to the decreased phonon population. Furthermore, valley polarization properties of UPL emission with circular polarization excitation is investigated. The demonstrated results will advance future photon upconversion applications based on monolayer TMDCs such as night vision, semiconductor laser cooling, and bioimaging.
General framework for calculating irradiance distributions of symmetric surface sources
Authors: Guerra-Yánez Carlos , Guerra Victor , Jurado-Verdú Cristo , Rabadán José , Pérez-Jiménez Rafael , Ghassemlooy Zabih , Zvánovec Stanislav
Published: November 2022

Symmetries in system modeling can be exploited to obtain analytical results on the system behavior and to speed up computations using the symmetric model. This work explores the use of symmetries in radiant surfaces for calculating the induced irradiance distributions by developing a general mathematical expression. The obtained model is applied to flat, cylindrical, and spherical sources to obtain explicit expressions. An experimental evaluation of the flat source is carried out and compared with a traditional point source, and the obtained procedure for the flat scenario is compared with the direct integration approach, which shows an improvement in the computation time of at least two orders of magnitude with a relative root mean square error of less than 10%. The results show that the proposed approach enhances short-range predictions for extended sources. To demonstrate the impact of this in optical wireless communications we have outlined a few applications.
Model-based fine phasing of segmented mirror using Chebyshev segmented piston-tip-tilt modes
Authors: Ren Hongxi , Dong Bing , Zhang Zexia
Published: November 2022

On-orbit cophasing is essential for high-resolution imaging of space telescopes with a segmented primary mirror. A model-based fine phasing method for a segmented mirror is proposed and demonstrated in this Letter. The tip-tilt error is related to the second moment of spot intensity, and the piston error is related to the Strehl ratio. Chebyshev segmented piston-tip-tilt (CSPTT) modes are used to express cophasing errors to suppress the effect of imaging noises. The CSPTT modal coefficients are estimated by the “2N + 1” algorithm that introduces bidirectional biases for each mode’s estimation. The proposed method is proved robust to image noises and figure errors.
Psychometric properties of the Sindhi version of the Mood and Feelings Questionnaire (MFQ) in a sample of early adolescents living in rural Pakistan
Authors: Shetty Janavi , Perquier Florence , Campisi Susan C. , Wasan Yaqub , Aitken Madison , Korczak Daphne J. , Monga Suneeta , Soofi Sajid Bashir , Szatmari Peter , Bhutta Zulfiqar A.
Published: November 2022

There is a need for reliable and valid screening tools that assess depressive symptoms in adolescents in Pakistan. To address this need, the present study examined the psychometric properties and factor structure of a Sindhi-translated and adapted version of the child-report Mood and Feelings Questionnaire (MFQ-C) and the Short Mood and Feelings Questionnaire (SMFQ-C) in a community sample of adolescents living in Matiari, Pakistan. Questionnaires were translated into Sindhi and administered by study psychologists to 1350 participants (52.3% female) 9.0 to 15.9 years old. Measurement structure was examined using confirmatory factor analysis. Internal consistency was estimated, and convergent and divergent validity were explored using subscales from the Strengths and Difficulties Questionnaire and the Screen for Child Anxiety Related Emotional Disorders. The unidimensional structure of the MFQ-C was found to be adequate, but a four-factor structure comprising core mood, vegetative, cognitive and agitated distress symptoms best fit the data (CFI = 0.97, TLI = 0.97, RMSEA = 0.05). The original unidimensional structure of the SMFQ-C was supported (CFI = 0.97, TLI = 0.96, RMSEA = 0.07). The MFQ-C and the SMFQ-C respectively showed excellent (α = 0.92) and good internal consistency (α = 0.87) as well as satisfactory construct validity with some differences observed across the MFQ-C subscales. The SMFQ-C and the adapted MFQ-C appear to be reliable and valid measures of depressive symptoms among early adolescents living in rural Pakistan. Both total and subscale scores can be derived from the MFQ-C to assess general and specific dimensions of depressive symptoms in this population.
The control of Hyalomma ticks, vectors of the Crimean–Congo hemorrhagic fever virus: Where are we now and where are we going?
Authors: Bonnet Sarah I. , Vourc’h Gwenaël , Raffetin Alice , Falchi Alessandra , Figoni Julie , Fite Johanna , Hoch Thierry , Moutailler Sara , Quillery Elsa
Published: November 2022

At a time of major global, societal, and environmental changes, the shifting distribution of pathogen vectors represents a real danger in certain regions of the world as generating opportunities for emergency. For example, the recent arrival of the Hyalomma marginatum ticks in southern France and the concurrent appearance of cases of Crimean–Congo hemorrhagic fever (CCHF)—a disease vectored by this tick species—in neighboring Spain raises many concerns about the associated risks for the European continent. This context has created an urgent need for effective methods for control, surveillance, and risk assessment for ticks and tick-borne diseases with a particular concern regarding Hyalomma sp. Here, we then review the current body of knowledge on different methods of tick control—including chemical, biological, genetical, immunological, and ecological methods—and the latest developments in the field, with a focus on those that have been tested against ticks from the genus Hyalomma. In the absence of a fully and unique efficient approach, we demonstrated that integrated pest management combining several approaches adapted to the local context and species is currently the best strategy for tick control together with a rational use of acaricide. Continued efforts are needed to develop and implement new and innovative methods of tick control.
The Molecular Medicine PhD program alumni perceptions of career preparedness
Authors: Chepp Valerie , Baker Claire , Kostiha Sarah , Smith Jonathan D.
Published: November 2022

Over the past two decades, graduate programs have sought to meet the rising need for cross-disciplinary biomedical and translational research training; however, among program evaluation efforts, little is known about student satisfaction with these programs. We report survey results aimed at assessing the overall satisfaction of Molecular Medicine (MolMed) PhD program graduates with their training program and subsequent employment, their research productivity since graduation, and the program elements important for entering their diverse career choices. The survey consisted of quantitative and qualitative instruments and was deployed in June 2020 via email to 45 alumni who had graduated at least two years prior. Investigators assessed mean and median Likert scale data and they conducted a qualitative content analysis on all open-ended narrative survey data using inductive analysis to identify themes. Of the 45 contacted, 26 PhD graduates of the MolMed program responded to the survey. Overall, graduates felt the MolMed curriculum prepared them well for their current career (mean 3.4 out a 4-point Likert scale); and, knowing what they know now, they would likely pursue a PhD degree again (mean 3.7 out of 4). Four overarching themes emerged from the content analysis of the narrative survey data: curriculum and other training experiences; professional skills; importance of a strong advisor/mentor; and, networking and career development. Overall, alumni were satisfied with their MolMed Program experience. They found the curriculum to be strong and relevant, and they believed that it prepared them well for their careers. There may be opportunities to embed additional skills into the curriculum, and the program should continue to offer a strong mentoring and clinical experience, as well as train students for diverse career trajectories.
Severe COVID-19 with persistent respiratory failure—A retrospective cohort study in a tertiary centre in Malaysia
Authors: Wong Chee Kuan , Sia Leng Cheng , Ooi Noreen Zhi Min , Chan Wai Yee , Pang Yong-kek
Published: November 2022

Introduction

Management of severe COVID-19 patients with persistent respiratory failure after acute phase treatment is not only challenging, but evidence for treatment is scarce, despite some authors reporting favourable clinical responses to corticosteroid therapy in histologically proven secondary organising pneumonia (OP). This study aimed to report the course of the disease, radiological pattern and clinical outcomes of severe COVID-19 patients with persistent respiratory failure.

Methods

This was a retrospective cohort study of severe COVID-19 patients who were admitted to a single tertiary centre from 1 January 2021 to 30 June 2021. The clinical data of the patients during admission and clinic follow-up, including radiological images, were traced using electronic medical records.

Results

In our cohort, the mortality rate for those with severe COVID-19 was 23.1% (173/749). Among the survivors, 46.2% (266/576) had persistent respiratory failure (PRF) after 14 days of illness. Of them, 70.3% (187/266) were followed up, and 68% (128/187) received oral corticosteroid (prednisolone) maintenance treatment. OP pattern made up the majority (81%) of the radiological pattern with a mean severity CT score of 10 (SD±3). The mean prednisolone dose was 0.68mg/kg/day with a mean treatment duration of 47 days (SD±18). About one-third of patients (67/187) had respiratory symptoms at 4 weeks (SD±3). Among 78.1% (146/187) who had a repeated CXR during follow-up, only 12 patients (8.2%, SD±3) had radiological improvement of less than 50% at 6 weeks (SD±3), with 2 of them later diagnosed as pulmonary tuberculosis. Functional assessments, such as the 6-minute walk test and the spirometry, were only performed in 52.4% and 15.5% of the patients, respectively.

Conclusion

Almost half of the patients with severe COVID-19 had PRF, with a predominant radiological OP pattern. More than two-thirds of the PRF patients required prolonged oral corticosteroid treatment. Familiarising clinicians with the disease course, radiological patterns, and potential outcomes of this group of patients may better equip them to manage their patients.
Is it really a piece of cake to label Geographical Indications with the Nutri-Score? Consumers’ behaviour and policy implications
Authors: Stiletto Alice , Trestini Samuele
Published: November 2022

To improve the dietary habits of the population, the EU, within the Farm to Fork strategy (F2F), is strongly supporting the Nutri-Score (NS) Front Of Pack (FOP) label. Under the NS system, Geographical Indications (GIs) are generally scored as “unhealthy” food, given the predominance of products of animal origin among GIs which are, notoriously, high-fat products. This study aims to determine the impact of the NS label on consumers’ preferences for two Protected Designation of Origin (PDO) cheeses, in comparison with generic ones. A Discrete Choice Experiment (DCE) was conducted on 600 Italian consumers through the estimation of a Random Parameter Logit model. Results highlighted that Italian consumers are generally not familiar with the NS and perceive it as a positive characteristic of the product, even if it is signalling an unhealthy choice (D score). However, consumers aware of the Nutri-Score meaning are willing to pay less to buy a product considered “unhealthy” according to this system. Furthermore, we found that consumers who already knew the NS system have homogeneous behaviours in rejecting the product, independently of the association with a PDO certification. This result has important implications on the agri-food sector. If the Nutri-Score becomes mandatory in the EU, consumers might refuse many GIs due to their negative Nutri-Score values. However, the quality of these products is recognized and protected worldwide. In this vein, the GI policy could be questioned by the F2F strategy: both of them aims to reduce information asymmetry producing, at the same time, contrasting results. Within the Geographical Indication policy, the PDO and PGI goods are protected for their quality attributes, which are strictly linked to their geographical origin of the products and traditional know-how. However, the EU adoption of the Nutri-Score could damage these products, reducing their perceived quality/value.
Analysis of two choir outbreaks acting in concert to characterize long- range transmission risks through SARS-CoV-2, Berlin, Germany, 2020
Authors: Reichert Felix , Stier Oliver , Hartmann Anne , Ruscher Claudia , Brinkmann Annika , Grossegesse Marica , Neumann Markus , Werber Dirk , Hausner Marius , Kunze Mareike , Weiß Bettina , Michel Janine , Nitsche Andreas , an der Heiden Matthias , Kriegel Martin , Corman Victor Max , Jones Terry Carleton , Drosten Christian , Brommann Tobias , Buchholz Udo
Published: November 2022

Background

Superspreading events are important drivers of the SARS-CoV-2 pandemic and long-range (LR) transmission is believed to play a major role. We investigated two choir outbreaks with different attack rates (AR) to analyze the contribution of LR transmission and highlight important measures for prevention.

Methods

We conducted two retrospective cohort studies and obtained demographic, clinical, laboratory and contact data, performed SARS-CoV-2 serology, whole genome sequencing (WGS), calculated LR transmission probabilities, measured particle emissions of selected choir members, and calculated particle air concentrations and inhalation doses.

Results

We included 65 (84%) and 42 (100%) members of choirs 1 and 2, respectively, of whom 58 (89%) and 10 (24%) became cases. WGS confirmed strain identity in both choirs. Both primary cases transmitted presymptomatically. Particle emission rate when singing was 7 times higher compared to talking. In choir 1, the median concentration of primary cases’ emitted particles in the room was estimated to be 8 times higher, exposure at least 30 minutes longer and room volume smaller than in choir 2, resulting in markedly different estimated probabilities for LR transmission (mode: 90% vs. 16%, 95% CI: 80–95% vs. 6–36%). According to a risk model, the first transmission in choir 1 occurred likely after 8 minutes of singing.

Conclusions

The attack rate of the two choirs differed significantly reflecting the differences in LR transmission risks. The pooled proportion of cases due to LR transmission was substantial (81%; 55/68 cases) and was facilitated by likely highly infectious primary cases, high particle emission rates, and indoor rehearsing for an extended time. Even in large rooms, singing of an infectious person may lead to secondary infections through LR exposure within minutes. In the context of indoor gatherings without mask-wearing and waning or insufficient immunity, these results highlight the ongoing importance of non-pharmaceutical interventions wherever aerosols can accumulate.
Improvements in airflow characteristics and effect on the NOSE score after septoturbinoplasty: A computational fluid dynamics analysis
Authors: Na Yang , Kim Youn-Ji , Kim Hyo Yeol , Jung Yong Gi
Published: November 2022

Septoturbinoplasty is a surgical procedure that can improve nasal congestion symptoms in patients with nasal septal deviation and inferior turbinate hypertrophy. However, it is unclear which physical domains of nasal airflow after septoturbinoplasty are related to symptomatic improvement. This work employs computational fluid dynamics modeling to identify the physical variables and domains associated with symptomatic improvement. Sixteen numerical models were generated using eight patients’ pre- and postoperative computed tomography scans. Changes in unilateral nasal resistance, surface heat flux, relative humidity, and air temperature and their correlations with improvement in the Nasal Obstruction Symptom Evaluation (NOSE) score were analyzed. The NOSE score significantly improved after septoturbinoplasty, from 14.4 ± 3.6 to 4.0 ± 4.2 (p < 0.001). The surgery not only increased the airflow partition on the more obstructed side (MOS) from 31.6 ± 9.6 to 41.9 ± 4.7% (p = 0.043), but also reduced the unilateral nasal resistance in the MOS from 0.200 ± 0.095 to 0.066 ± 0.055 Pa/(mL·s) (p = 0.004). Improvement in the NOSE score correlated significantly with the reduction in unilateral nasal resistance in the preoperative MOS (r = 0.81). Also, improvement in the NOSE score correlated better with the increase in surface heat flux in the preoperative MOS region from the nasal valve to the choanae (r = 0.87) than in the vestibule area (r = 0.63). Therefore, unilateral nasal resistance and mucous cooling in the preoperative MOS can explain the perceived improvement in symptoms after septoturbinoplasty. Moreover, the physical domain between the nasal valve and the choanae might be more relevant to patient-reported patency than the vestibule area.
Incentive conflict and supply contracts under carbon cap policy
Authors: Kuiti Mithu Rani , Basu Preetam , Ghosh Debabrata
Published: November 2022

Environmental regulations, once promulgated, can cause incentive conflict between manufacturers and suppliers. A manufacturer facing the regulation may undertake choices that can affect his sourcing decisions with the supplier. To analyze this, we develop a game-theoretic model considering a manufacturer who faces a per-unit carbon emissions cap and sources from a supplier. The manufacturer operates in a carbon sensitive market. We analyze the responses of the manufacturer and supplier and show that since the burden of carbon emissions cap is borne by the manufacturer, the first-best outcomes are not reached. Therefore, the supplier may offer different contracts to incentivize the manufacturer. We study two mechanisms: the two-part tariff and the revenue-and-investment sharing contracts. We show how such contracts achieve coordination and deliver efficient supply chain outcomes. Interestingly, we find that the contract preferences of the manufacturer and the supplier may not be the same and vary under different market conditions. Summarily, we highlight important considerations for the supply chain players in designing suitable incentives.