bluuebunny/crossref_metadata_2025 huggingface dataset:
Synergistic Therapeutic Potential of Curcumin and Quercetin Co-Administration in Alzheimer’s Disease: Insights from Transgenic Drosophila melanogaster Models
Authors:   Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria., Odubela Olukayode Olusola , Olanrewaju Afeez John ,   Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria., Daniel Eniekezimene Deborah ,   Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Sagamu, Ogun State, Nigeria.
Published: February 2025

Glycogen Synthase Kinase 3 beta (GSK-3β) activation promotes intracellular neurofibrillary tangles (NFTs) and extracellular amyloid beta plaques formation which are the major hallmarks of Alzheimer’s disease (AD). Oxidative stress and mitochondria dysfunction have been implicated in the perturbation of GSK-3β. Curcumin and quercetin are phytochemicals with antioxidant and anti-inflammatory properties. This study was aimed at investigating the neuroprotective effects of curcumin and quercetin on AD models of Drosophila melanogaster. Flies were grouped into five (5) groups containing one hundred and fifty flies per group. First group (wild control) received distilled water; second group (Wild treated) received 200 mg/kg of curcumin and quercetin; third group (transgenic) received distilled water; fourth group (transgenic+LD) received 50 mg/kg of curcumin and quercetin; fifth group (transgenic + HD) received 200 mg/kg of curcumin and quercetin for duration of five days. Survival assay, climbing assay, catalase, total thiol, acetylcholinesterase, and malondialdehyde level were investigated at the end of treatment duration. Additionally a molecular docking analysis was performed using PyRx and curcumin and quercetin were docked against the implicated protein GSK-3β and this showed higher binding affinities than the standard. This study showed that curcumin and quercetin improved locomotor activity and survival rate and increased total thiols levels and catalase activity and decreased MDA and AChE activities. Overall curcumin and quercetin ameliorated AD in D. melanogaster. Therefore, co-administration can be regarded as a possible therapeutic agent for AD.
Molecular Study of (Mycoplasma pneumoniae, Streptococcus pneumoniae) in respiratory infections patients in thiqar province
Authors: Rehab abdulhassan Ajed  , Basim abdulhussein Jarullah
Published: February 2025

The high death and hospitalization rates caused by bacterial respiratory infections make them a major worldwide health problem. Acute otitis media, bacterial rhinosinusitis, pharyngotonsillitis, bronchitis, and community-acquired pneumonia are among the common respiratory tract illnesses caused by common bacterial respiratory infections, which include Streptococcus pneumoniae, Mycobacterium tuberculosis, Haemophilus influenzae, Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila.                                                                 
The study aimed to detect (Mycoplasma pneumoniae) and Streptococcus pneumoniae  that caused respiratory infections and determined if it caused this infection. The study included 140 patients (67males and 73     females) who were suffering from respiratory infections, ages ranging from 10-80 years, in a period from 1 September 2023 to 1 February 2024, all of the 140 samples collected from Nasiriyah Teaching Hospital, Center for Chest Diseases and Respiratory Diseases in Nasiriyah, Souq Al-Shuyoukh General Hospital, Alhussein Teaching Hospital, Private Clinics in Shatrah. Specimens included a sputum sample  and oropharyngeal swab for direct detecting by polymerase chain reaction (pcr) Diagnosis is based on the presence of the (16s rRNA) gene to detect (Mycoplasma pneumoniae, Streptococcus pneumoniae) patients had with un-cultivated bacteria where 3\140(2.14%) of patients had infection with Mycoplasma pneumoniae and 6\140(4.28%) with Streptococcus pneumoniae
The present study was conducted that the most detected bacterial in female group 6 (75.0%), while in the male group 2 (25.0%), in addition, the most isolated bacteria in female group were both M. pneumoniae 3 (50.0%), and S. pneumoniae 3 (50%),whil in age groups  in first group 3, while non-detected bacteria in both fourth and seventh age group 0,
Quality Evaluation of Some Selected Commercially Imported Honey Available in Libyan Markets
Authors: Ismail Ajaj  , Kalthoum Awn  , Wafa Khalleefah  , Mahasn Kubbat  , Hanan Mosbah  , Huda Jelani
Published: February 2025

The present work was conducted to evaluate the quality of ten brands of honey commercially available in the Libyan market. The moisture, color intensity, ash content, pH, and hydroxymethylfurfural (HMF) content were detected according to AOAC 1990-Official Methods and reference methods. The results were compared with Libyan Standard Legislation and the FAO's international standards.The results indicate that the color intensity of the honey samples varied, ranging from water white to dark amber. The study found that Australian honey in the UAE had the highest pH value, while floral honey from France exhibited the lowest. The moisture content ranged from 4.42% to 16.87%, and the ash content varied between 0.0037% and 0.287%. The results also indicated that the Spanish honey recorded the highest HMF value at 177.39 and 151.26 mg/kg, whereas Australian honey packed in the UAE had the lowest HMF value at 1.81 mg/kg. Some samples exceeded both FAO's international standards and Libyan standards.
Prevalence of Cow Milk Protein Allergy among Libyan Asthmatic Children
Authors: Ola Elzigallai  , Hisham Alrabty
Published: February 2025

Coexistent food allergy and asthma is a significant burden in the pediatric population, and the incidences of both have increased dramatically over the past two decades. Cow milk protein allergy is the most common allergy in children with prevalence between 1.8% and 7.5% during the first year of life. The variability between studies may be attributable to different methods used for diagnosis, the different ages of the populations studied or to geographical factors. The purpose of this study is to determine the prevalence and clinical impact of cow milk protein allergy in Libyan asthmatic children. This was a crosssectional study done between December 2021 and December 2022 at Tripoli children hospital. The study included 200 asthmatic children who regularly attending the childhood asthma clinic. Detailed questionnaire was used, and data were analyzed using SPSS and presented as descriptive statistics. Out of 200 asthmatic children included, 10% of them had cow milk protein allergy, their mean age was 2.7± 2.6years, and about 80% of cases were below 5 years of age (P < 0.05). Furthermore, our findings exhibited significant association between family history of atopy and cow milk protein allergy (P < 0.05). About 45% of asthmatic cases were affected by cow milk protein allergy, of which 5% of them had progressive course. Future studies should aim to include larger samples of cow milk protein allergy cases, which allow sufficient statistical power to uncover the epidemiology of this allergy.
Estimate Expression Levels of LPA Receptor 1, and LPA Receptor 2 Genes Epithelial Ovarian Cancer Cell Lines Using qPCR and Immunocytochemistry Approach
Authors: Mustafa Esmaio  , Faghri Februrary
Published: February 2025

Epithelial ovarian carcinoma accounts for the highest number of mortalities among patients with ovarian cancer. However, the molecular mechanisms fundamental to Epithelial Ovarian Cancer (EOC) tumorigenesis are presently ambiguous. In this study, a Real-time–quantitative polymerase Chain Reaction(RT-qPCR) was selected to manipulate Lipoprotein Receptor 1(LPAR1), and Lipoprotein Receptor 2 (LAPR2) gene expression in ovarian cancer cell lines. Immunocytochemical staining was used to examine the expression of LPAR1, 2 in Ovarian Adenocarcinoma W42 (OAW42) and Cystadenocarcinoma Ovary( SKOV3), which are ovarian cancer cell lines, and using Human Ovarian Surface Epithelium Cell (HOSEpiC) as a negative, which was created, from human ovarian surface epithelial cells. The results established that LPAR1, 2 expressions were upregulated in OAW42 and SKOV3 when using the qPCR technique to assist, however, the immunocytochemistry results showed the expression of LPAR1, and LPAR2 in the OAW42 SKOV3and HOSEpiC which is indicated that both of LPAR1 and LPAR2 are not good biomarkers to detect the Epithelial Ovarian Cancer at an early stage. In conclusion, the results of the present study indicate the correlation between LPAR1 and LPAR2 does not serve as biomarkers or diagnostic targets in EOC on the other hand, using qPCR and Immunocytochemistry (ICC) techniques is considered good tools to use.
Nephrogenic diabetes insipidus: potential treatments and their mechanisms of action.
Authors: Alabeedi Siraj , Elkawafi Mohamed
Published: February 2025

Nephrogenic diabetes insipidus (NDI) is a rare disease caused by the complete or partial resistance of the kidneys to antidiuretic hormone (ADH). NDI associated with excessive urine production and severe thirst. There are two types of NDI; acquired NDI and congenital NDI.   Acquired NDI is the most common type among adults, with several factors that can cause acquired NDI, for instance, lithium therapy and electrical disorders. Congenital NDI can occur due to mutations in either the arginine vasopressin receptor 2 (AVPR2) gene or the aquaporin-2 (AQP2) gene. New effective treatments for NDI are required because the disease can be life treating if left untreated. Current animal studies showed that rolipram and metformin are two potential treatments for congenital NDI by upregulation the apical expression of AQP2 channels. Other animal studies illustrated that the combination of different drugs, such as, secretin agonist and fluvastatin could be an effective method to treat XNDI. Furthermore, some agents were found to be able to treat more than one type of NDI, for example, sildenafil citrate could be potently used to treat acquired NDI and XNDI, while statins could be promising treatments for congenital NDI and autosomal NDI. However, further investigation and human trials are needed before it can be decided if these drugs can be clinically used as a treatment for NDI.
Penerapan Model Pembelajaran Project Based Learnig (PjBL) dalam Meningkatkan Keterampilan Berpikir Kreatif Siswa pada Mata Pelajaran PAI di SMAN 2 Palangka Raya
Authors: Muthaharoh Nur Rahmadani , Malisi M. Ali Sibram , Gofur Abdul
Published: February 2025

Mengingat pentingnya keterampilan berpikir kreatif sebagai salah satu kompetensi abad 21, penelitian ini bertujuan untuk mengoptimalkan keterampilan tersebut pada siswa kelas X-9 SMAN 2 Palangka Raya. Untuk mencapai tujuan ini, diterapkan model pembelajaran Project Based Learning (PjBL) dalam pembelajaran Pendidikan Agama Islam (PAI). Studi ini berhasil membuktikan bahwa penerapan model pembelajaran berbasis proyek (PjBL) dapat secara efektif meningkatkan keterampilan berpikir kreatif siswa. Temuan ini diperoleh melalui analisis data kuantitatif yang dikumpulkan menggunakan kuesioner online pada kelompok eksperimen tunggal, dengan menggunakan desain pra-eksperimen one-group pretest-posttest. Hasil analisis statistik menunjukkan adanya perbedaan yang signifikan antara skor pretest dan posttest, yaitu pada pretest setiap indikatornya berada pada rentang nilai 71-80 yang termasuk kategori kreatif. Sedangkan hasil postest pada setiap indikatornya berada pada rentang nilai 81-100 yang termasuk kategori sangat kreatif.
Analisis Perbandingan Jumlah File Carving untuk Format Ekstensi NTFS, FAT32 dan EXfat
Authors: Rahman M Agus Kholilur , Prayudi Yudi , Ramadhani Erika
Published: February 2025

Penelitian ini bertujuan untuk membandingkan hasil pemulihan file dari sistem file NTFS, FAT32, dan exFAT menggunakan perangkat lunak Foremost. Fokus utama penelitian ini adalah mengevaluasi tingkat keberhasilan pemulihan file berdasarkan jenis, ukuran, dan integritas file yang dapat dipulihkan dari masing-masing sistem file. Penelitian ini juga bertujuan untuk menganalisis efektivitas Foremost dalam menangani karakteristik unik dari ketiga sistem file tersebut. Hasil penelitian diharapkan memberikan informasi yang bermanfaat bagi pengguna dalam menentukan sistem file yang optimal dan alat pemulihan yang efektif untuk kebutuhan pemulihan data pada berbagai kasus kehilangan informasi dan data. Penelitian ini dilakukan mengingat minimnya kajian yang mengangkat perbandingan langsung antara NTFS, FAT32, dan ExFAT dalam konteks file carving. Hipotesis yang diuji adalah bahwa sistem file ExFAT akan menghasilkan kualitas output yang lebih baik dibandingkan NTFS dan FAT32. Eksperimen dilakukan dengan berbagai skenario pengujian untuk mengukur kinerja pemulihan data, yang meliputi tingkat keberhasilan pemulihan, kecepatan pemrosesan, dan akurasi hasil carving. Hasil penelitian menunjukkan bahwa setiap sistem file memiliki keunggulan dan kelemahan masing-masing dalam hal kinerja file carving. Dengan adanya perbandingan ini, diharapkan dapat memberikan panduan yang berguna bagi para profesional forensik digital dalam memilih strategi pemulihan yang tepat sesuai dengan format sistem file yang dihadapi. Penelitian ini memberikan kontribusi penting dalam memperkaya literatur forensik digital serta menjadi referensi yang bermanfaat bagi penanganan media penyimpanan oleh pemeriksa forensik digital.
Analisis Pemanfaatan Metode Eksperimental dalam Mengembangkan Keterampilan Sains pada Anak Usia Dini
Authors: Rahmawati Dina , Fitri Roquyyah , Malaikosa Yes Matheos Lasarus
Published: February 2025

Abstrak penelitian ini bertujuan untuk menganalisis pemanfaatan metode eksperimen dalam mengembangkan keterampilan sains pada anak usia dini. Penelitian ini menggunakan pendekatan kualitatif dengan metode literature review untuk menggali dan menganalisis hasil-hasil penelitian terdahulu yang relevan. Tujuan utama penelitian ini adalah untuk memahami bagaimana metode eksperimen dapat diimplementasikan dalam konteks pendidikan anak usia dini, serta mengidentifikasi faktor-faktor yang mempengaruhi efektivitas penerapannya. Hasil dari berbagai penelitian terdahulu menunjukkan bahwa metode eksperimen dapat mendorong anak untuk belajar melalui pengalaman langsung, yang memperkuat pemahaman mereka terhadap konsep-konsep sains. Metode ini juga terbukti efektif dalam meningkatkan kemampuan observasi, analisis, dan pemecahan masalah anak. Analisis tematik digunakan untuk mengkategorikan dan mengelompokkan temuan-temuan dari literatur yang ada, sehingga dapat disusun sintesis mengenai pengaruh metode eksperimen terhadap perkembangan keterampilan sains pada anak. Pembahasan juga mencakup rekomendasi bagi pengembangan kurikulum dan strategi pengajaran yang lebih adaptif dengan mempertimbangkan peran guru, media pembelajaran, serta lingkungan yang mendukung eksperimen. Penelitian ini memberikan kontribusi penting dalam mengembangkan pembelajaran sains yang lebih menyeluruh bagi anak usia dini.
Revitalisasi Materi Pendidikan Islam: Penerapan Materi Pendidikan Islam Berbasis Fiqih
Authors: Sulwana Siti , Chaniffudin Chaniffudin
Published: February 2025

Revitalisasi materi pendidikan Islam, khususnya yang berbasis fiqih, menjadi penting untuk menjawab tantangan pendidikan di era modern. Upaya ini bertujuan untuk mengintegrasikan ajaran fiqih dengan perkembangan ilmu pengetahuan dan teknologi, sehingga pendidikan Islam dapat tetap relevan dan efektif dalam membentuk karakter generasi muda. Penerapan materi pendidikan berbasis fiqih tidak hanya menekankan pada aspek teori, tetapi juga pada praktik yang aplikatif dalam kehidupan sehari-hari. Dengan menggunakan pendekatan inovatif seperti pembelajaran interaktif dan pemanfaatan teknologi digital, diharapkan siswa dapat memahami dan mengamalkan ajaran fiqih secara lebih baik. Namun, revitalisasi ini juga menghadapi berbagai tantangan, seperti kualitas sumber daya manusia dan persepsi masyarakat terhadap pendidikan agama. Oleh karena itu, diperlukan strategi yang komprehensif untuk meningkatkan kualitas pendidikan Islam berbasis fiqih agar dapat menghasilkan lulusan yang handal dan siap menghadapi tantangan zaman.
Representasi Konflik Keluarga dalam Film “Air Mata di Ujung Sajadah”
Authors: Bimantara Juanda Billal , Suksmawati Herlina
Published: February 2025

Konflik dalam keluarga merupakan suatu keniscayaan, Konflik keluarga dapat terjadi karena adanya perilaku oposisi atau ketidasetujuan antara anggota keluarga. Penelitian ini bertujuan untuk mendeskripsikan representasi konflik keluarga dalam film “Air Mata di Ujung Sajadah”. Metode kualitatif deskriptif digunakan dalam penelitian ini. Sumber data penelitian ini adalah film “Air Mata di Ujung Sajadah”. Peneliti akan melihat representasi konflik keluarga dengan menggunakan semiotika John Fiske dengan teori kode-kode televisi terhadap adegan-adegan yang menggambarkan konflik keluarga. Hasil penelitian mengungkapkan bahwa konflik keluarga dalam film “Air Mata di Ujung Sajadah” direpresentasikan dengan konflik keluarga antara orang tua dan anak, antara lain orang tua yang tidak menyetujui pernikahan anaknya, orang tua yang membohongi anaknya. Konflik antara ibu kandung dan ibu angkat merupakan konflik yang terjadi dalam memperebutkan hak asuh anak mereka. Selain itu, peneliti juga menemukan penggambaran ideologi patriarki dan feminis.
Strategi Pengembangan Kampung Wisata Tematik Danau Kalpataru sebagai Wisata Urban Nature Berbasis Partisipasi Masyarakat di Banjar Wijaya, Tangerang
Authors: Ritonga Roozana Maria , Halim Cindy Clarissa
Published: February 2025

Penelitian ini bertujuan untuk mengidentifikasi potensi, tantangan, dan manfaat pengembangan Desa Tematik Danau Kalpataru sebagai ekosistem wisata berkelanjutan. Melalui pendekatan berbasis masyarakat, warga setempat terlibat aktif dalam merancang, mengelola, dan mempromosikan destinasi ini. Mereka berkontribusi dalam perencanaan tata ruang, pengembangan fasilitas, serta menyelenggarakan kegiatan pendidikan budaya dan lingkungan. Manfaat pengembangan wisata ini juga dirasakan secara sosial dan ekonomi, sehingga memberikan dampak positif pada hubungan sosial antar warga. Namun, tantangan dalam pengembangan Desa Tematik Danau Kalpataru juga harus diatasi. Isu keberlanjutan, seperti pengelolaan sumber daya air dan peningkatan kunjungan wisatawan yang tidak direncanakan, dapat mengancam kelestarian lingkungan. Oleh karena itu, diperlukan strategi pengelolaan yang komprehensif dan partisipatif untuk meminimalkan dampak negatif. Dengan berbagai potensi dan tantangannya, Desa Wisata Tematik Danau Kalpataru tidak hanya menjadi destinasi wisata, tetapi juga contoh keberhasilan pembangunan berbasis masyarakat, ramah lingkungan dan budaya. Hasil penelitian menunjukkan bahwa Desa Wisata Tematik Danau Kalpataru dapat berkembang secara berkelanjutan sekaligus memberikan manfaat ekonomi dan sosial bagi masyarakat setempat, tidak hanya menjadi tempat rekreasi, tetapi juga sarana edukasi bagi pengunjung dari semua lapisan masyarakat.
Proses Pembentukan Ragam Gaul Generasi Alpha di Media Sosial Tiktok
Authors: Kartika Dwi Ayu , Mualafina Rawinda Fitrotul , Prayogi Icuk
Published: February 2025

Bahasa gaul atau ragam bahasa gaul merupakan bahasa yang digunakan oleh remaja yang setiap generasinya menunjukan penggunaan ragam bahasa gaul yang berbeda. Seperti halnya setiap remaja pada generasi tertentu mempunyai ciri khasnya masing-masing seperti pada remaja generasi alpha. Tujuan dari penelitian ini, yaitu mendeskripsikan proses pembentukan ragam bahasa gaul generasi alpha pada media sosial tiktok yang terdapat pada akaun @uplkp, @shaidinamaulana, @mrci.tv, @danielalvinjr dan @icha.lovely. Pendekatan yang digunakan, yaitu dengan  metode deskriptif kualitatif. Teknik pengumpulan data dalam penelitian ini menggunakan teknik simak bebas libat cakap (SBLC) dan teknik catat. Teknik analisis yang digunakan yaitu dengan teknik padan, teknik yang digunakan untuk analisis bahasa dari faktor eksternal. Dalam hal ini faktor eksternalnya adalah faktor sosial dari  penggunaan ragam gaul generasi alpha dan menarik kesimpulan. Hasil penelitian yang dilakukan yakni terdapat beberapa proses pembentukan ragam bahasa gaul pada generasi alpha yang ditemukan, diantaranya: (1) kata tunggal, (2) frasa, (3) singkatan, (4) pemendekan, dan (5) kata berafiks -ing
Pengembangan instrumen Evaluasi Higher Order Thinking Skills Berbasis Etnosains pada Pembelajaran IPAS Kurikulum Merdeka
Authors: Suttrisno Suttrisno
Published: February 2025

Pengembangan alat evaluasi HOTS dalam penelitian ini didasarkan pada temuan di tahap analisis kebutuhan (define) yang menunjukkan rendahnya kemampuan berpikir tingkat tinggi (HOTS) peserta didik di MI. Guru sering menggunakan alat evaluasi konvensional berupa tes berbasis kertas dengan tipe soal yang hanya berpatokan pada buku paket, yang kurang mendukung pengembangan HOTS. Penelitian ini bertujuan untuk mengembangkan alat evaluasi HOTS berbasis etnosains pada pembelajaran IPAS Kurikulum Merdeka yang valid dan reliabel, serta untuk mengetahui dampaknya terhadap kemampuan berpikir peserta didik. Metode penelitian menggunakan Research and Development (RnD) dengan model ADDIE yang terdiri dari analisis, perancangan, pengembangan, implementasi, dan evaluasi. Validasi dilakukan oleh tiga ahli: media/tampilan, instrumen, dan bahasa. Instrumen yang dikembangkan berupa soal pilihan ganda dan penjodohan. Hasilnya, alat evaluasi digital yang dikembangkan terbukti interaktif dan efektif, serta telah tervalidasi dengan persentase validasi ahli media 95%, ahli instrumen 90%, dan ahli bahasa 93,8%, sehingga dikategorikan sangat baik tanpa perlu revisi. Analisis butir soal menunjukkan bahwa tingkat kesulitan berada pada kategori sedang hingga sulit, dengan nilai rentang 0,16-0,70.
An Analysis of Simile Translation Using Pierini Translation Strategy in Critical Eleven Indonesian Novel into English
Authors: Odelia Risca Jovita
Published: February 2025

This study was conducted to investigate what translation strategies are used in translating figurative language which is a simile in Indonesian into English in the novel Critical Eleven by Ika Natassa. The theory of simile translation strategies proposed by Pierini is used as the theoretical framework of this research. Moreover, this research uses qualitative research and the method used is descriptive research. The data were classified by identifying and analyzing the strategies used to translate the similes in the source text based on Pierini’s theory. The result of this study shows that all of the strategies that have been used to translate the simile identified in the novel and the dominant strategy used is literal translation or retention of the same vehicle (70,0%) by the translator to translate the simile.
Peran Komunikasi Organisasi dalam Mengubah Toxic Workplace Environment
Authors: Nurrahmawati Milda , Toni Ahmad , Prakoso Jatayu Hadi
Published: February 2025

Dalam era transformasi digital dan perubahan sosial yang cepat, fenomena lingkungan kerja yang toxic semakin menjadi sorotan dalam dunia organisasi. Tantangan ini tidak hanya mengancam kesejahteraan individu, tetapi juga mempengaruhi produktivitas dan keberlanjutan organisasi secara keseluruhan. Lebih dari 70% karyawan mengaku merasa tidak terlibat dalam pekerjaan mereka, di mana salah satu penyebab utamanya adalah komunikasi yang tidak efektif dan kultur organisasi yang tidak mendukung. Penelitian ini bertujuan untuk mengkonstruksikan peran komunikasi organisasi dalam mengurangi dampak negatif lingkungan kerja yang toxic, serta mendorong terciptanya budaya organisasi yang lebih positif. Penelitian ini menggunakan pendekatan kualitatif deskriptif dan analisis literatur yang mendalam. Hasil temuan menunjukkan bahwa peran komunikasi organisasi dapat mengubah lingkungan kerja toxic dengan adanya komunikasi yang terbuka, transparan, dan dua arah mampu mengatasi konflik, memupuk kepercayaan, dan meningkatkan keterlibatan karyawan. Meskipun ada pemahaman yang semakin mendalam tentang dampak buruk lingkungan kerja yang toxic, masih terdapat perubahan signifikan dalam implementasi strategi komunikasi yang efektif di lapangan dan budaya organisasi. Penelitian ini merekomendasikan penyusunan kebijakan komunikasi yang lebih inklusif dan peningkatan pelatihan bagi pemimpin organisasi dalam menciptakan iklim komunikasi yang positif, guna mencapai tujuan bersama dan kesuksesan berkelanjutan.
Model Intervensi Pekerjaan Sosial dalam Pemberdayaan Ekonomi Keluarga Penyandang Disabilitas: Pendekatan Participatory Action Research
Authors: Bakarbessy Derek
Published: February 2025

Penelitian ini mengkaji model intervensi pekerjaan sosial dalam pemberdayaan ekonomi keluarga penyandang disabilitas dengan pendekatan participatory action research melalui metode kajian literatur sistematis. Analisis dilakukan terhadap 75 artikel yang dipublikasikan dalam rentang waktu 2019-2024, meliputi jurnal internasional, jurnal nasional, buku, dan laporan penelitian. Hasil penelitian menunjukkan adanya pergeseran paradigma dari model medis ke model sosial dan HAM dalam pemberdayaan disabilitas. Model intervensi yang mengintegrasikan pendekatan sistem ekologis, strength-based, dan community development menunjukkan tingkat keberhasilan tertinggi (82%). Faktor-faktor kritis keberhasilan program mencakup dukungan kebijakan, penguatan modal sosial, dan akses terhadap sumber daya. Penelitian ini merekomendasikan pengembangan model intervensi terintegrasi, penguatan kapasitas praktisi, dan penelitian lanjutan untuk mengukur dampak jangka panjang program pemberdayaan ekonomi keluarga penyandang disabilitas.
Analisis Sistem Pengelolaan Pengaduan Pelayanan Publik Nasional Mencegah Maladministrasi pada Sekretariat Daerah Kabupaten Jeneponto
Authors: Maldun Syamsuddin , Suaib Muhmmad Ridho , Afrisal Ade ferry
Published: February 2025

Layanan SP4N_LAPOR merupakan layanan integrasi aduan digital diciptakan untuk menghasilkan pengelolaan aduan masyarakat yang komunal. Penerapan SP4N_LAPOR di Kabupaten Jeneponto mengakibatkan adanya perubahan mekanisme dan pelaksana pengelola aduan di Kabupaten Jeneponto. Sejak mengalami pengembangan pada tahun 2021, SP4N_LAPOR secara teknis menghapus tatanan unit pengelola aduan (UP4). SP4N_LAPOR merubah pelaksanaan pengelolaan aduan dan aspirasi masyarakat di wilayah Kabupaten Jeneponto. Selain itu, pemerintah masih sempat mengalami fluktuasi dalam mengenalkan layanan sejak awal penerapan belum merambah menggunakan SP4N_LAPOR.  Jenis penelitian yang digunakan yaitu fenomenologis dan pendekatan kualitatif. Metode pengumpulan data yang dipakai adalah trianggulasi yaitu: survey, interviuw, dan analisis dokumen. Analisis data menggunakan koleksi data, kondensasi data, penyajian data, verifikasi dan penarikan kesimpulan. Hasil penelitian menunjukkan Kabupaten Jeneponto telah mengimplementasikan adanya good governance melalui SP4N_LAPOR yang berjalan cukup baik antara pemerintah dengan masyarakat di Kabupaten Kendal. Namun, terdapat penghambat dan kendala dalam implementasi tersebut seperti sosialisasi yang kurang masif dan menyasar seluruh masyarakat, keterbatasan anggaran dan kurang responsifnya beberapa admin OPD sehingga menyebabkan laporan aduan dan aspirasi masyarakat belum secara menyeluruh terkelola dan hasil penanganan aduan fluktuatif serta banyak masyarakat yang belum mengetahui SP4N_LAPOR.
Makna Laba Bagi Kelompok Tenun Lo`A Ulimuri
Authors: Indryani Yulista , Kado Kristina Valen , Asmara
Published: February 2025

Penelitian ini bertujuan untuk mengeksplorasi makna laba bagi kelompok tenun Lo`a Ulimuri, dengan fokus pada bagaimana laba dipersepsikan dan dimanfaatkan oleh para pelaku usaha dalam komunitas ini. Menggunakan pendekatan kualitatif, penelitian ini melibatkan wawancara mendalam Bersama anggota kelompok tenun untuk menggali pandangan mereka mengenai laba. Hasil penelitian menunjukkan bahwa bagi kelompok tenun Lo`a Ulimuri, laba tidak hanya dipandang sebagai pemenuhan kebutuhan finansial, tetapi juga sebagai simbol warisan budaya. Laba dianggap penting untuk mensejahterakan anggota kelompok, memperkuat ikatan sosial dengan menjalin tali kasih persaudaraan dalam suka maupun duka, dan melestarikan warisan budaya tenun.  Penelitian ini mengungkapkan makna laba yang lebih luas dan mendalam, mencakup dimensi sosial, budaya, dan ekonomi. Temuan ini memberikan wawasan tentang pentingnya laba dalam konteks budaya dan komunitas, serta dampaknya bagi strategi pemberdayaan ekonomi yang berkelanjutan dan inklusif.
Jurnal mengenai Analisis Komprehensif Harga Pokok Penjualan Tenun Ikat Lepo Lorun Dengan Pendekatan Activity Based Costing
Authors: Krowin Maria Trappistin Ose , Manise Theresia Vitriana , Londa Constantia Natalia , Nurak Maria Oktaviana Dua , Teluma Maria Claudia Mongang
Published: February 2025

Industri kerajinan tenun ikat merupakan salah satu sektor yang berpotensi untuk dikembangkan di Indonesia. Namun demikian masih ada tantangan yang dihadapi. Salah satu tantangan utama dalam industri ini adalah penentuan Harga Pokok Produksi (HPP) yang kurang akurat. Penelitian ini menggunakan pendekatan kualitatif. Peneliti menggunakan wawancara semi terstruktur yang termasuk dalam kategori wawancara mendalam yang prinsipnya bersifat fleksibel. Data yang telah didapat kemudian diverifikasi menggunakan teknik triangulasi sumber. Penjelasan ini memberikan gambaran yang jelas tentang, seberapa efektif penggunaan biaya per aktivitas selama proses produksi. Dengan menggunakan metode ABC membantu sanggar (Rumah Tenun) Lepo Lorun menemukan dan membagi biaya overhead produksi secara lebih akurat dan efisien. Ini memungkinkan mereka menetapkan harga jual yang lebih tepat dan kompetitif serta meningkatkan manajemen biaya selama proses produksi secara keseluruhan. Hasil analisis menunjukkan bahwa metode ABC memberikan perhitungan biaya produksi yang lebih akurat dan komprehensif dibanding metode konvesional. Dengan ABC semua biaya overhead yang terkait dengan berbagai aktivitas produksi mulai pembuatan benang hingga penenunan dan penjualan dapat dialokasikan secara lebih tepat. metode ini membantu sanggar Lepo Lorun menetapkan harga jual yang lebih kompetitif dengan meningkatkan efisinsi manajemen biaya secara keseluruhan.
A Peran Kepuasan Kerja Sebagai Mediator Hubungan Antara Pengembangan Karier Terhadap Niat Untuk Tinggal
Authors: Istiana Dien , Susanti Riana , Amir Ja'far
Published: February 2025

Meningkatnya kasus karyawan yang mengundurkan diri, telah mendorong penulis untuk melakukan penelitian kuantitatif terhadap karyawan banks swasta di Bekasi. Pendekatan SEM-PLS dipergunakan untuk tujuan menganalisa hubungan pengembangan karier, kepuasan kerja dan niat untuk tinggal. Hasil penelitian menunjukkan bahwa Kepuasan kerja sepenuhnya memediasi hubungan antara pengembangan karir dan niat untuk bertahan karyawan bank swasta. Ini berarti bahwa pengembangan karir secara positif mempengaruhi kepuasan kerja, yang pada gilirannya meningkatkan niat karyawan untuk tetap bersama bank. Oleh karena itu, meningkatkan kepuasan kerja melalui inisiatif pengembangan karir sangat penting untuk mempertahankan karyawan di bank. Perlu dilakukan penelitian lebih lanjut dengan Analisa Multy Group analysis
Integrasi Artificial Intelligence dalam Pembelajaran Pendidikan Agama Islam
Authors: Wahyuni Andi Eki Dwi , Yaumi Muhammad , Arsyad Azhar , Husain Saddam
Published: February 2025

This article aims to explore the integration of artificial intelligence in Islamic Religious Education (PAI) learning to improve the effectiveness, efficiency, and inclusivity of the learning process, as well as the benefits and impacts of AI in PAI. This study uses a qualitative approach using the literature review method. This method involves collecting, analyzing, and synthesizing relevant literature, including journal articles, books, reports, and conference proceedings, to identify existing practices, challenges, and potential advancements in this field. The data is sourced from leading academic databases such as Google Scholar. The inclusion criteria prioritize research that addresses the application of AI in education, its role in improving Islamic learning, and related ethical considerations. The results of the analysis show that the integration of AI in Islamic religious education has brought significant changes in the way learning and teaching are carried out. This technology provides easy access to religious information sources, such as sacred texts, tafsir, hadith, and other important literature, which supports more inclusive and in-depth learning. AI also allows for personalized learning that suits the individual needs of learners, helping to improve understanding of religious concepts more effectively. Additionally, AI offers an edge in data analysis that allows educators to better understand learners' progress and devise more effective teaching strategies
Pembelajaran Akhlak pada Interaksi Al-Khadir AS dan Musa AS Perspektif Al-Qur’an
Authors: Wahyudi Udi , Sarnoto Ahmad Zain
Published: February 2025

This study examines the moral learning model that can be done by establishing approaches, strategies, methods and learning techniques that occur in Al-Khadir and Musa. In implementing the learning program on the interaction of Al-Khadir and Musa, Al-Khadir did more dialogue, question and answer and example. Example turns out to have a greater influence than speech. This research is a type of qualitative research. Data analysis is carried out qualitatively with the stages of data reduction, data presentation, and conclusion drawing. This study concludes that in the process of learning morals in the interaction of Al-Khadir and Musa, there are positive and commendable values to be implemented in daily moral learning, both formal and informal. This research uses a qualitative approach and an analytical descriptive method that uses the type of literature research and maudhu'i interpretation. The results of this study found that the story of the Prophet Moses AS and the Prophet Al-Khadir AS contained in Surah Al-Kahfi [18]: 60-82 contains various wisdom about moral learning and can be implemented in daily life.
Analisis Kemampuan Literasi Matematika dan Numerasi Ditinjau dari Gaya Kognitif Siswa pada Materi Bilangan Bulat
Authors: Iqbal Muhammad Adam , Jamilah Jamilah , Risalah Dewi
Published: February 2025

This study aims to find out the results of literacy and numeracy skills reviewed from students' cognitive styles. This study uses qualitative research methods. The form of this research is a case study. This research was carried out at SMP Negeri 13 Pontianak. The subjects of this study are students in grade VII F who have studied integer material. The subjects to be interviewed consisted of 4 students based on the categories of Field Independent and Field Dependent cognitive styles. The subject of this study was determined using a purposive sampling technique. The instruments used in this study are the GEFT test, written test and interview guidelines. The data produced was analyzed in a qualitative descriptive manner. The results of the study showed that students with mathematical literacy and numeracy skills in the FD category were only able to achieve 2 indicators out of 3 indicators. This is because students with the FD category also tend to hesitate and easily give up in dealing with the problems they face, while with the FI category students are able to meet 3 indicators. This is because students with the FI category are always optimistic and do not give up easily in solving the problems they face.
Pengaruh Pendidikan Karakter dan Disiplin Belajar Terhadap Hasil Belajar Siswa Setingkat Sekolah Dasar
Authors: Umar Hanif , Lisan Moh Fasikhul
Published: February 2025

This study aims to analyze the influence of character education and learning discipline on student learning outcomes at the elementary school (SD) level. Character education is one of the strategic approaches to shaping students' attitudes, values, and morals, while learning discipline plays an important role in creating consistent and structured learning habits. The method used is a literature review by analyzing various relevant sources of previous research. The source comes from Google Scholar data, namely articles published until the end of 2024. The data was analyzed in a qualitative descriptive manner. The results of the study show that character education has a positive impact on the formation of positive attitudes of students, such as responsibility, honesty, and cooperation, which directly supports the improvement of learning outcomes. On the other hand, learning discipline has been proven to improve concentration, time management, and student motivation in learning. The combination of effective character education and good learning discipline makes a significant contribution to the achievement of optimal learning outcomes. Thus, this study suggests the importance of integrating character education in the curriculum and habituating learning disciplines from an early age to support the success of student learning at the elementary level
Peningkatan Pemahaman Pembelajaran IPA Materi Perkembangbiakan Bunga Sutra Bombay Melalui Metode Outdoor Learning Bagi Disabilitas Rungu
Authors: Ruwaidah Ruwaidah , Budi Setia
Published: February 2025

This research aims to improve the understanding of science learning on the propagation of bombay silk flowers through the outdoor learning method for students with hearing disabilities. This research method is Classroom Action Research (PTK). The data collection techniques used are tests, observations, and documentation. The data produced were analyzed qualitatively and quantitatively. The results show that the outdoor learning method improves students' understanding. Based on the test, AG obtained a score of 92.3% while MA and KL 84.6%, Based on the results of the research that has been carried out and presented in chapter IV, it can be concluded that the understanding of science of bombay silk flower breeding material for Class IX deaf people at SLB N 1 Lubuk Basung can be improved through the outdoor learning method.
Pengaruh Penggunaan Media Kahoot Terhadap Hasil Belajar Materi Keragaman Suku Bangsa dan Budaya pada Siswa Kelas IV UPT SD Negeri 232 Gresik
Authors: Wulandari Diah Ayu , Suprihatien Suprihatien , Yuanta Friendha
Published: February 2025

This study aims to determine the influence of the use of Kahoot media on the learning outcomes of ethnic and cultural diversity materials. This study uses a quantitative approach with a type of quasi experiment research whose population is all grade IV students, which is divided into two groups, namely class IV A with 14 students as the experimental group and class IV B with 13 students as the control group. The data collection technique used is a test in the form of multiple-choice questions. Validity and reliability tests are carried out to test the instrument. Furthermore, a normality test was carried out with the results of the variable =2,26, the variable while , while the results of the postes homogeneity test  this was stated that both variables were declared to be normally distributed and homogeneous. To find out whether or not there is an influence of Kahoot media in learning, the results of which showed that the learning outcomes of the Ethnic and Cultural Diversity material of grade IV A students who were taught using Kahoot learning media were better than without using Kahoot media in learning on Ethnic and Cultural Diversity material.
Evaluating the efficacy of ethanolic extract of Tapak Liman (Elephantopus scaber L.) leaf in inhibiting pulmonary fibrosis: Mechanisms through anti-fibrotic cytokine promotion
Authors: Alghoull Asadig , Firdausi Salma , Christina Yuyun , Widyarti Sri , i Muhaimin , Djati Muhammad
Published: February 2025

Background:
Pulmonary fibrosis represents the most prevalent form of idiopathic interstitial pneumonia. The pathogenesis of pulmonary fibrosis using a bleomycin-induced mice model has indicated an imbalanced immune response such as an early massive inflammatory response, followed by fibrosis development. Therapy focused on restraining inflammation is one of the ways to inhibit fibrosis development. Elephantopus scaber ethanolic extract (ESEE) is known to have many beneficial compounds that were proven to possess anti-inflammatory activities, but its prospect in inhibiting pulmonary fibrosis development needs to be investigated.

Aim:
This study aimed to evaluate the potency of ESEE treatment in inhibiting fibrosis development in the bleomycin-induced pulmonary fibrosis mice model.

Methods:
Healthy male BALB/c mice were divided into seven experimental groups (n=8): healthy mice (N), vehicle mice (VC), pulmonary fibrosis mice (C-), pulmonary fibrosis received dexamethasone (C+), pulmonary fibrosis mice received E. scaber ethanol extract (ESEE) at a 0.0504 mg/kg BW (D1), 0.1008 mg/kg BW (D2), and 0.2016 mg/kg BW (D3). Mice were given ESEE orally and intraperitoneal bleomycin injection daily for 14 days. Mice were then sacrificed on days 7 and 14 and spleens were isolated to determine the production of IL-10, TNF-α, and IFN-γ using flow cytometry.

Results:
The results revealed that a remarkable increase of TNF-α was found in the macrophage of pulmonary fibrosis mice model from day 7 to 14. An increase in IFN-γ production was also observed on day 7 and then decreased on day 14. The production of IL-10 was reduced in the fibrosis group at day 7 and continued to increase at day 14. Interestingly, ESEE treatment for 14 days could effectively reduce TNF-α and increase IFN-γ production. ESEE treatment could also maintain a stable production of IL-10 at each time point. ESEE at 0.1004 mg/kg BW (D2) showed the most effective activity in reducing pro-fibrotic cytokine than the dexamethasone group.

Conclusion:
Ethanolic extract of Elephantopus scaber leaves (ESEE) has demonstrated its beneficial prospect in regulating pro-inflammatory and pro-fibrotic cytokine to inhibit fibrosis development.
Antioxidant activity, antibacterial behavior, and anticancer impact of Egyptian propolis
Authors: Gomaa Marwa , Abdelhameed Khaled , Sobhy Sherien , Konper Hanan , Hassanein Zienab , Saleh Ahmed , Jamal Mamdoh , Hafez Elsayed
Published: February 2025

Background:
Propolis, a resinous substance produced by bees, exhibits significant phytochemical and biological properties, which have been explored for various therapeutic applications.

Aim:
This study investigates the phytochemical composition, antioxidant activity, antibacterial efficacy, and anticancer potential of ethanolic extracts from three propolis samples (P1, P2, and P3).

Methods:
Phytochemical screening was conducted to determine the presence of bioactive compounds such as ascorbic acid, saponins, and tannins. Antioxidant activity was evaluated using the phosphomolybdate (PMA) and ferric reducing power (FRP) assays. The antibacterial efficacy against Salmonella typhimurium and Staphylococcus aureus was assessed using the well diffusion method. Cytotoxicity and anticancer effects were investigated using the MTT assay on red blood cells (RBCs) and various carcinoma cell lines (HepG2, MDA, and A549). Gene expression analysis was performed using RT-qPCR to assess the upregulation of immune response genes (P53, Bcl2, Bax, Ca125, and C3).

Results:
Phytochemical screening revealed considerable quantities of ascorbic acid, saponins, and tannins in the propolis samples. The P1 sample exhibited the most substantial antioxidant activity, with FRP values at 62.9 mg/g DM and PMA content at 20.7 mg/g DM. In antibacterial assays, P1 demonstrated the highest inhibitory zones at the maximum concentration (400 mg/mL), outperforming standard antibiotic treatments. In cytotoxicity and anticancer assays, P1 preserved the highest percentage of RBCs from haemolysis and showed marked anticancer activity, with the lowest cell viability observed at 3.9 µg/mL. Gene expression analysis revealed significant upregulation of immune response genes, particularly in MDA and HepG2 cell lines upon P1 treatment.

Conclusion:
This study underscores the potent antioxidant, antibacterial, and anticancer properties of propolis, highlighting its potential as a natural therapeutic agent. The observed activities suggest promising applications for propolis in combating bacterial infections and various cancer types, warranting further exploration into its molecular mechanisms and potential clinical uses.
Unraveling the morphological and molecular profile of Setaria digitata in Aceh cattle
Authors: Helmi Teuku , Farida Farida , Kasturi Aisyah , Rahmah Ella , Winaruddin Winaruddin , Hanafiah Muhammad
Published: February 2025

Background:
The Setaria nematode, classified within the order Spirurida and family Setariidae, predilection in the peritoneal cavity of its host, with mosquitoes acting as vectors for transmitting microfilariae to cattle, its primary host.

Aim:
This study investigates the morphology and molecular characteristics of Setaria digitata in Aceh cattle and evaluates the effectiveness of three staining solutions lactophenol, glycerol, and lugol 2% for visualizing adult worms.

Methods:
A total of 124 blood serum and adult worm samples were collected from Aceh cattle at slaughterhouses in Banda Aceh and Bireuen. Microfilariae detection was conducted using the Knott test, while worm morphology was assessed via Polymerase Chain Reaction (PCR) amplification of the 12S rDNA and cox1 genes.

Results:
Each staining solution enhanced worm morphology visualization with varying benefits. The lugol 2% solution offered a complete view of morphology but lacked detail for internal structures. Lactophenol improved visibility of both morphology and internal organs, though sample integrity declined quickly. Glycerol displayed both the morphology and internal structures with clarity, making it the most effective option overall. Molecular amplification results showed a 450 bp band for the 12S rDNA gene and a 680 bp band for the cox1 gene in S. digitata.

Conclusion:
Glycerol proved superior for maintaining morphology and visualizing internal structures of S. digitata. Molecular profiling using the 12S rDNA and cox1 genes effectively confirmed the identity of Setaria digitata, underscoring the value of these genetic markers for species identification.