bluuebunny/crossref_metadata_2025 huggingface dataset:
Panacea to Domestic Gas Supply Accessibility and Affordability in Nigeria
Authors: Ugolo Jerry Obaro , Iwegbu Michael
Published: August 2023

Nigeria with a proven gas resource base of over 206tcf possesses the biggest gas reserve in the continent of Africa and is the 9th largest in the World (NUPRC website, 2021). However, Nigeria faces the challenge of making clean cooking gas accessible and affordable for its populace. Investments in making cooking gas affordable will improve the economy of the average household and reduced carbon footprint in this part of the world.

The Nigerian Government by March 29th, 2021 proclaimed the following decade, the decade of gas reform and development. The blueprint of a Nigerian Gas Master Plan (NGMP) focusing on accelerating the growth of the country's gas sector was to be adopted. Efforts required in this plan would include developing better-adapted technologies and delivery models, and stronger institutional frameworks. Substantial efforts are required across the region to help convert the abundant natural gas resources into adequate domestic gas utilization and hence for national development.

A key factor for making clean gas accessible and affordable for all, is to have in place, gas infrastructure for storage and distribution. A number of Nigerian oil and gas production platforms still flare their gas due to inadequate gas processing, treatment, and storage facilities. Other factors hindering development of the domestic gas sector include the non-adoption of modern gas recovery technology, inadequate media enlightenment, and stakeholders’ willingness to invest in carbon footprint reduction initiatives.

Using quantitative research methodology, the researcher looked at the pricing of Liquified Petroleum Gas (LPG) over a 7-year (2016-2022) period. Examination of the gas infrastructure development within the same period was also analysed to determine if more gas has been made available in the Nigerian market. A survey was done to ascertain possible factors affecting investment in gas sector of Nigeria. Secondary data was obtained from the World bank databases showing revenue generated from gas amongst top 10 African countries. This helped to show value obtained from the gas sector.

Key benefits for making domestic gas accessible and affordable would include, improved Gross Value Addition (GVA) for investors and the national economy, better health conditions for the millions already affected by using solid biomass (firewood and charcoal) for cooking as well as reduction in carbon emissions.
Research on Slam and Path Planning Method based on Multi-sensor Fusion in Complex Factory Scene
Authors: zhang yang , Zhou Yanjun , Hao Hao , Wei FangFang , Zhang Ranran
Published: August 2023

The scene of large factories is complex, and the requirements for production safety are higher. At present, complex factories mainly use manual operation mode to carry out safety inspection, that is, manual inspection and manual recording mode to inspect factory equipment, which has the disadvantages of high labor intensity, low work efficiency and unstable inspection quality. In recent years, with the development of robot navigation related technologies, it has provided a new idea for solving autonomous navigation in large-scale and complex factory environment with variable obstacles. Therefore, we design a slam and path planning method based on multi-sensor fusion, including the establishment of complex and large-scale factory maps, dynamic obstacle avoidance and local path planning, which can achieve accurate and efficient autonomous positioning and effectively generate smooth and safe paths. The security, smoothness, flexibility and efficiency of this method are verified in various complex simulation scenarios and challenging real world. It is proved that this method can meet the performance requirements of positioning and path planning in large-scale complex industrial scenes, and has a good application prospect.
CFD-DEM model of plugging in flow with cohesive particles
Authors: Saparbayeva Nazerke , Balakin Boris V.
Published: August 2023

Plugging in flows with cohesive particles is crucial in many industrial and real-life applications such as hemodynamics, water distribution, and petroleum flow assurance. Although probabilistic models for plugging risk estimation are presented in the literature, multiple details of the process remain unclear. In this paper, we present a CFD-DEM model of plugging validated against several experimental benchmarks. Using the simulations, we describe the process focusing on inter-particle collisions and plugging dynamics. We conduct a parametric study altering the Reynolds number (3000...9000), particle concentration (1.6...7.3%), and surface energy (25...541 mJ/m 2). We note the process possesses complex non-linear behaviour for the cases where the particle-wall adhesion reduces by more than 20% relative to the inter-particle cohesion. Finally, we demonstrate how the simulation results match the flow maps based on the third-party experiments.
Protocol for a randomized control trial of the Building Regulation in Dual Generations Program (BRIDGE); Preventing the intergenerational transmission of mental illness in at-risk preschool children
Authors: Penner-Goeke Lara , Belows Madeline , Kristjanson Amanda , Andrade Brendan F. , Cameron Emily E. , Giuliano Ryan , Katz Laurence Y. , Kelly Lauren E. , Letourneau Nicole , Mota Natalie , Reynolds Kristin , Zalewski Maureen , Pharazyn Ashley , Roos Leslie E.
Published: August 2023

Background: Since the onset of the COVID-19 pandemic, the worldwide prevalence of maternal depression has risen sharply; it is now estimated that one-quarter of mothers experience clinically significant depression symptoms. Exposure to maternal depression during early childhood increases the risk for the development of childhood mental illness (MI) in offspring, with altered parenting practices mediating the association between maternal depression and child outcomes. Dual-generation interventions, which aim to simultaneously treat parent and child mental health, show promise for improving outcomes for mothers with depression and their young children. The Building Regulation in Dual Generations (BRIDGE) program combines Dialectical Behavior Therapy (DBT) and parenting skills training to concurrently treat maternal depression and improve parenting practices. In pilot within-group studies, BRIDGE has led to large reductions in maternal depression and child MI symptoms. The aim of the current study is to evaluate the efficacy of BRIDGE in reducing maternal depression and child MI symptoms (primary outcomes) as well as parenting stress and harsh parenting (secondary outcomes).
Methods: A three-armed randomized control trial with equal group sizes will be conducted to compare the efficacy of (1) BRIDGE (DBT + parenting skills), (2) DBT skills training, and (3) services-as-usual. Participants (n=180) will be mothers of 3- to 5-year-old children who report elevated depression symptoms. Those randomized to BRIDGE or DBT skills training will complete a 16-week group therapy intervention. Assessments will be administered at pre-intervention(T1) post-intervention (T2), and 6-month follow-up (T3).
Discussion: Dual-generation programs offer an innovative approach to prevent the intergenerational transmission of mental illness. The current study will add to the evidence base for BRIDGE by comparing it to a stand-alone mental health intervention and a services-as-usual group. These comparisons will provide valuable information on the relative efficacy of including parenting support in a mental health intervention for parents. Results will contribute to our understanding of how maternal depression affects children’s development, and how intervening at both a mental health and parenting level may affect child and family outcomes.
Trial registration: Name of registry: Clinical Trials Protocol Registration and Results System; Trial registration number: NCT05959538; Date of registry: July 24, 2023; Available: https://classic.clinicaltrials.gov/ct2/show/NCT05959538
Fungal spillover influences plant competitive ability and affects species’ coexistence
Authors: Errico Gina , Zhang Bo , Bachelot Benedicte Marie Philippe
Published: August 2023

Tropical forests are the most biodiverse ecosystems in the world and are critical to global ecosystem functions. Anthropogenic activities have increased forest fragmentation, which could introduce new biotic interactions into tropical forests via spillover, yet little is known about how spillover influences tropical tree diversity. Existing spillover theory has mainly focused on transmission dynamics rather than plant species coexistence. We developed a theoretical spatial model consisting of one predator (fungi) interacting with two prey (plant) populations and introduced a new fungal pathogen via diffusion to mimic spillover. We aimed to understand how spillover pathogen host-specificity, spillover intensity, and plant competitive abilities alter plant coexistence outcomes. Results show that spillover, contingent on plant species’ competitive ability, can either promote or disrupt coexistence. While spillover disrupts plant existence at the forest edge, generalist spillover acts as an equalizing mechanism, enabling plants with different competitive abilities to coexist. In contrast, specialized spillover acts as a stabilizing mechanism when targeting the strong plant competitor, eventually reversing plant apparent competitive abilities. These effects are heightened with wind. Our model provides insight on the influences of fungal pathogen spillover on plant community composition and diversity when the effects of fungal spillover in field are unknown.
Unraveling the development and secretory structures of the atypical flowers of Dalea purpurea (Leguminosae: Papilionoideae)
Authors: Martins Santiago Macario , Mansano Vidal de Freitas , Leite Viviane Gonçalves , Paulino Juliana Villela
Published: August 2023

Dalea purpurea, an herbaceous papilionoid legume of the North American Great Plains, has floral characteristics that are highly atypical within subfamily Papilionoideae, such as organs reduction, low differentiation among petals, with keel absence, adnation between petals and stamens and presence of anther glands. This study aims to elucidate the ontogenetic processes responsible for its atypical architecture. Floral buds and flowers were processed by scanning electron microscope (SEM) and light microscope (LM). Five sepals initiate in a modified unidirectional order, followed by five petals simultaneously. The five antesepalous stamens initiate in a bidirectional order. No antepetalous stamens primordia were initiated, suggesting that the presumed evolutionary reduction from ten to five stamens in Dalea was due to ontogenetic pathway organ absence since the initiation. The single and central carpel is precocious, emerges concomitantly with the first stamen primordium. The hypanthium is short, and the ovary is superior, with a short stipe. The five anthers are dorsifixed and rimose, with elongated glandular dorsal and apical appendages. The petals are clawed, and positioned like a hood above the reproductive whorls during development. We found an adnation of the basal region of the filaments to the petal claws, forming a stemonozone. The structure, on the abaxial side, forms an elongated sheath through the adnation of the stamens to four weakly differentiated petals to the height of the calyx lacinia. The adaxial petal (banner) is free for the most part, with adnation only at the base of the stemonozone, forming the apron. The peculiar feature absence of the typical staminal tube seems to be circumvented by the adnation of the five stamens to the five petals and the position of the adaxial petal in D. purpurea, which looks like it performs a similar function to that of the diadelphous staminal tube of other Papilionoideae. The diversity and distribution of floral secretory structures indicate that this species, which lost part of its floral specialization, might be using chemical defenses as protection against the predation of the reproductive organs. Thus, we conclude that the atypical Dalea pupurea’s floral architecture is due to some ontogenetic events associated with evolutionary and environmental pressures.
Simulating AMOC tipping driven by internal climate variability with a rare event algorithm.
Authors: Cini Matteo , Zappa Giuseppe , Ragone Francesco , Corti Susanna
Published: August 2023

This study investigates the possibility of Atlantic Meridional Overturning Circulation (AMOC) noise-induced tipping solely driven by internal climate variability without applying external forcing that alter the radiative forcing or the North Atlantic freshwater budget. We address this hypothesis with an innovative approach by applying a rare event algorithm to ensemble simulations of present-day climate with an intermediate complexity climate model. The algorithm successfully identifies trajectories leading to abrupt AMOC slowdowns, which are unprecedented in a 2000-year control run. Part of these AMOC weakened states lead to collapsed state without evidence of AMOC recovery on multi-centennial time scales. The temperature and Northern Hemisphere jet stream responses to these internally-induced AMOC slowdowns show strong similarities with those found in externally forced AMOC slowdowns in state-of-the-art climate models. The AMOC slowdown seems to be initially driven by Ekman transport due to westerly wind stress anomalies in the North Atlantic and subsequently amplified by a complete collapse of the oceanic convection in the Labrador Sea. These results demonstrate that transitions to a collapsed AMOC state purely due to internal variability in a model simulation of present-day climate are rare but physically possible. Additionally, these results show that rare event algorithms are a tool of valuable and general interest to study tipping points since they introduce the possibility of collecting a large number of tipping events that cannot be sampled using traditional approaches. This opens the possibility of identifying the mechanisms driving tipping events in complex systems in which little a-priori knowledge is available.
Fabrication of automotive titanium bipolar plates by uniform pressure electromagnetic incremental forming based on arc spiral coil
Authors: Wang Qiangkun , junrui xu , Zhao Yudong , Wang Shaobo , Wang Yuanfeng
Published: August 2023

Facing the forming requirements of large-sized automotive titanium bipolar plates (BPPs), a uniform pressure electromagnetic incremental forming (UP-EMIF) process was utilized. Corresponding simulation and analysis were conducted based on the designed arc spiral coil. Analysis of the magnetic field revealed that during the forming process, electromagnetic forces on the coil wire tended to compress in radial direction, while the electromagnetic forces on the outer channel exhibited repulsive tendencies toward the driver sheet, and the electromagnetic forces on the driver sheet transitioned from a wavy pattern to a uniform distribution. Velocity and equivalent strain analysis showed that the maximum deformation velocity of the blank occurred at the bottom of the channel, reaching 195m/s. The highest equivalent strain of the blank occurred in the rounded corner R region, which was prone to thinning of wall thickness. Based on these findings, UP-EMIF and traditional quasi-static drive rubber pad forming (QS-DRPF) experimental devices were developed, and a comparative study on the forming of 0.1mm thick automotive titanium BPPs was conducted. Research indicated that successful production of a titanium BPP measuring 485mm×195mm was achieved using three consecutive discharges of 9kV in each discharge region under the discharge capacitor of 100μF, an acceleration distance of 2mm, a coil overlap rate of 15%, and a 0.3mm thick Cu110 driver sheet. The depth of the channels was 0.4mm (channel depth-to-width ratio of 0.53). Compared to traditional QS-DRPF, the 9kV UP-EMIF reduced channel thinning effectively, with a maximum thinning rate of 18.2%, while simultaneously improving channel filling, with a maximum filling rate of 96.3%. This demonstrates the feasibility of UP-EMIF as a process for fabricating automotive titanium BPPs.
Metric type-II radio bursts and space weather phenomena: A statistical study
Authors: Devi Pooja , Miteva Rositsa , Chandra Ramesh , Koleva Kostadinka , Lawrance Bendict
Published: August 2023

In this paper, we present for the first time a comprehensive statistical study on metric type II radio bursts (m-IIs) and their associated solar and space weather (SW) phenomena, namely, solar flares (SFs), sunspot (SN) configu- rations, coronal mass ejections (CMEs), their interplanetary (IP) counterparts (ICMEs) and shocks, filaments, in situ detected particles and geomagnetic storms (GSs). The radio signatures were identified from dynamic spectra provided by the ground-based RSTN network distributed over the globe with nearly complete diurnal coverage. Based on the recently completed catalog of m-IIs in solar cycle 24, we perform the temporal and spatial association between the radio emission and listed above activity events. The remaining data is collected from various space-based satellites, ground-based observatories or public catalogs. We complement the m-II results with m+IP IIs where the IP IIs are identified from the Wind/WAVES spacecraft. Occurrence rates are calculated and presented as a function of the strength of the specific SW event type: higher rates are obtained with CMEs, SFs, and SN configurations, whereas a much weaker relationship is found with ICMEs, IP shocks, energetic particles, and GSs. The obtained relationships can be utilized in empirical or physics-based models for SW forecasting.
CSSMA: A novel algorithm of slime mold optimzer for global optimization problems
Authors: Wang Tian-Lei , Chen Le-Qing , Gu Shao-Wei , Wang Zhu , Xu Ying
Published: August 2023

The Slime Mold Algorithm (SMA) is a popular optimization algorithm in recent years. However, it suffers from weaknesses in exploration capability, insufficient balance, and a tendency to get trapped in local optima. To address these issues, this paper proposes a novel Slime Mold Algorithm based on Cosine Similarity and Population Range Neighborhood Selection Mechanism (CSSMA).Firstly, a population range neighborhood selection mechanism is designed to enhance the algorithm's exploration capability. This mechanism allows for a better exploration of the solution space during the optimization process. Next, an embedded uniform nonlinear adaptive operator is introduced to improve the balance between exploration and exploitation in SMA. This step ensures that the algorithm can effectively explore promising areas while also exploiting the identified regions.Moreover, a cosine similarity-based escape mechanism is proposed to enhance the optimization precision and promote population diversity in SMA. This mechanism assists the algorithm in breaking away from local optima and exploring the global solution space more effectively.In the validation phase, CSSMA is evaluated using 12 selected test functions out of 23 classic test functions through ablation experiments. Additionally, numerical experiments and Wilcoxon rank-sum tests are performed on all 23 test functions to compare the performance of the proposed improvements with other benchmark algorithms. The results validate the effectiveness of the proposed CSSMA, as it demonstrates a significant improvement in optimization precision and overall performance, making it more competitive than other compared algorithms.
CNN-based Hot-Rolled Steel Strip Surface Defects Classification: A Comparative Study Between Different Pre-Trained CNN Models
Authors: Bouguettaya Abdelmalek , Zarzour Hafed
Published: August 2023

During the manufacturing process, hot-rolled steel strip surface defects occur frequently. These defects cause economic losses and risks in the use of these products. Therefore, it is crucial to develop automatic inspection systems to identify these defects. In the last few years, computer vision has emerged as an effective tool to identify these defects. Deep learning-based computer vision techniques, especially Convolutional Neural Networks (CNN), achieved state-of-the-art results for most computer vision tasks, including image classification. These results are obtained using a large amount of data. However, collecting such large datasets in the manufacturing field remains a challenging task. To overcome such a problem, a transfer learning-based framework with multiple CNN variants is proposed in this study. Therefore, different state-of-theart and widely used pre-trained CNN architectures, including VGG-16, VGG-19, ResNet50, ResNet50V2, InceptionV3, InceptionResNet-V2, MobileNet-V1, MobileNet-V2, MobileNet-V3 Small, and NASNetMobile, combined with transfer learning were investigated to evaluated their performances in classifying hot-rolled steel strips surface defects. The experimental results showed that MobileNet-V2 and InceptionResNetV2- based methods achieve better performance than all other models in terms of accuracy, loss, training and inference times, and model size.
Bilinear $\omega$-type Calder\'{o}n-Zygmund operator and its commutator on product of grand mixed generalized Morrey spaces
Authors: Lu Guanghui , Wang Miaomiao , Tao Shuangping
Published: August 2023

In this paper, we first introduce a grand mixed generalized Morrey spaces $M^{P),\Psi(\cdot)}_{u}(\mathbb{R}^{n})$, where $P=(p_{1},\cdots,p_{n})\in(1,\infty)^{n}$, $\Psi(\cdot)=(\psi_{1}(\cdot),\cdots,\psi_{n}(\cdot))$ is $n$-tuple of positive increasing functions $\psi_{i}$ defined on intervals $(0,p_{i}-1]$ for $i=1,\cdots,n$, and\\$u(X,r): \mathbb{R}^{n}\times(0,\infty)\rightarrow(0,\infty)$ is a Lebesgue measurable function; especially, if we take $\Psi(\Upsilon):=\Upsilon^{\Theta}$ with $0<\Upsilon:=(\varepsilon_{1},\cdots,\varepsilon_{n})0$, then the space $M^{P),\Psi(\cdot)}_{u}(\mathbb{R}^{n})$ is denoted by $M^{P),\Theta}_{u}(\mathbb{R}^{n})$. Furthermore, we establish the embeddingand density properties for the spaces $M^{P),\Psi(\cdot)}_{u}(\mathbb{R}^{n})$. Finally, as some applications, we prove that a bilinear $\omega$-type Calder\'{o}n-Zygmund operator$\widetilde{T}_{\omega}$ is bounded from the product of spaces $M^{P_{1}),\Theta}_{u_{1}}(\mathbb{R}^{n})\times M^{P_{2}),\Theta}_{u_{2}}(\mathbb{R}^{n})$ into spaces $M^{P),\Theta}_{u}(\mathbb{R}^{n})$; and also show that the commutator $\widetilde{T}_{\omega,b_{1},b_{2}}$ generated by $b_{1},b_{2}\in\mathrm{BMO}(\mathbb{R}^{n})$ and $\widetilde{T}_{\omega}$ is bounded from\\ the product of spaces $M^{P_{1}),\Theta}_{u_{1}}(\mathbb{R}^{n})\times M^{P_{2}),\Theta}_{u_{2}}(\mathbb{R}^{n})$ into spaces $M^{P),\Theta}_{u}(\mathbb{R}^{n})$, where $u_{1}u_{2}=u$ and $1<\infty$.Moreover, the boundedness of $\widetilde{T}_{\omega}$ and $\widetilde{T}_{\omega,b_{1},b_{2}}$ on the product of grand mixed Morrey spaces$M^{P_{1}),\Theta}_{q_{1}}(\mathbb{R}^{n})\times M^{P_{2}),\Theta}_{q_{2}}(\mathbb{R}^{n})$ is established.
Initiation of Dendritic Failure of LLZO via Sub-Surface Lithium Deposition
Authors: Siniscalchi Marco , Shi Yifu , Li Guanchen , Gibson Joshua , Bonilla Ruy , Speller Susannah , Grovenor Chris
Published: August 2023

The occurrence of lithium deposition in occluded spaces within ceramic electrolytes due to electronic leakage currents can jeopardise the commercialization of power-dense solid-state batteries. Here, we utilize plasma-FIB serial sectioning to visualize the surface and sub-surface of a garnet solid electrolyte (LLZO) after lithium plating. We study the morphology of surface spallation cracks, which represent the initial stage of dendrite formation. Employing a LiMg anode, we track the magnesium diffusion around these surface cracks with EDS. The absence of magnesium in early-stage cracks suggests they form due to the pressure build-up from the deposition of pure lithium in occluded pores near the electrolyte surface. These spallation cracks act as current focusing and stress concentration hot spots. Electron beam induced current imaging demonstrates that short-circuiting lithium dendrites grow from the spallations during plating. Thus, the sub-surface deposition of lithium is a possible explanation for the initiation of lithium dendrites in LLZO.
Hashimoto’s thyroiditis negatively influences IVF outcome in euthyroid women on T4 substitution therapy; a retrospective study
Authors: Herman Tünde , Török Péter , Laganà Antonio Simone , Chiantera³ Vito , Jakab Attila
Published: August 2023

Purpose: We retrospectively analyzed how the presence of thyroid autoimmunity (TAI positive) affected reproductive parameters in eighty-six (86) TAI positive women referred to IVF treatment.
Methods: All participants diagnosed with subclinical or overt hypothyroidism, while euthyroid on thyroxine replacement. Sixty-nine (69) female patients in the same IVF program, with no thyroid abnormalities served as controls (TAI negative group).
Results: Statistically significant baseline hormone profile differences were found in multiple parameters between the two groups. TAI positive women were older (mean age 34.7±5.42 vs. 32.32±5.04 years; p=0.002), had higher FSH (8.4±3.49 U/L vs. 7.04±2.32 U/L; p=0.024), higher E2 (53.94±47.61 vs. 42.93±18.92 pg/ml; p=0.025) levels, while their AMH (2.88±2.62 vs. 3.6±1.69 ng/ml; p=0.0002) was lower. There were no differences in TSH levels (1.64±0.96 vs. 1.66±0.65 uIU/ml; p= 0.652) between the two groups, FT3 (2.63±0.58 vs. 2.98±0.55 pg/ml; p=0.002) was lower and FT4 (1.304±0.29 vs. 1.13±0.21 ng/dl; p=0.0002) was higher in the TAI positive group.
Egg cell counts (6.0±3.82 vs. 7.5±3.95; p=0.015), clinical pregnancy rate (36.04 % vs. 69.56 %; p<0.001), live birth rate (23.25 % vs. 60.86 %) were lower, the miscarriage rate (35.48 % vs. 12.5 %; p=0.024) was higher in the TAI positive group. There was no difference in ICSI fertilization rate (69.12 % vs 62.91 %, p=0,12), although the fertilization rate was lower for patients under 35 in the TAI positive group, after adjusting for age.
Conclusion: TAI positive women carry a multitude of endocrine and metabolic parameters which may contribute to unfavorable effects on reproductive health.
Determination of the Optimal Elliptical Trajectories Around the Earth and Moon
Authors: Carter Thomas , Humi Mayer
Published: August 2023

Current space exploration programs call for the establishment of a permanent Human presence on the Moon. This paper considers periodic orbits of a shuttle between the Earth and the Moon. Such a shuttle will be needed to bring supplies to the Moon outpost and carry back those resources that are in short supply on Earth. To keep this shuttle in permanent periodic orbit it must have a thruster that forces it into an elliptical orbit from perigee near Earth to an apogee just beyond the Moon and back to perigee. The impacts of the Earth, Moon and Sun gravity on this orbit are considered. For this model we determine the eccentricity that minimizes the thrust requirements and the lunar ∆ υ requirements. We show that optimal placements of the eccentricity of the shuttle orbit can produce significant improvement in thrust (and fuel) requirements.
Zero Knowledge and Oblivious Ads Recommendation
Authors: Rajagopalan Anirudh , Singh Kunwar , Jayashrri Balaji , John Anu E
Published: August 2023

Interest-based Advertising, sometimes called online behavioural advertising, uses data collected from online activity on a digital device (e.g. smart phone, tablet, computer, etc.) using cookies, pixel tags, and other technologies to show personalized ads. While interest-based advertising is invaluable in helping advertisers reach the most suitable audience for their products, user privacy could be better protected if it could be accomplished without collecting a particular individual’s browsing history. This paper aims to implement an amalgamation of cryptography techniques that leverage zero-knowledge proof (ZKP) cryptography and oblivious transfer (OT) alongside standard hashing and fuzzy logic to ensure that users’ sensitive, personal and private data is always kept secure.
Pseudomonas putida as saviour for troubled Synechococcus elongatus in a synthetic co-culture – Interaction studies based on a multi-OMICs approach
Authors: Pflueger-Grau Katharina , Kratzl Franziska , Urban Marlene , Pandhal Jagroop , Shi Mengxun , Kleigrewe Karin , Meng Chen , Kremling Andreas
Published: August 2023

In their natural environments, microbes rarely exist in isolation; instead, they thrive in consortia where diverse interactions take place. In this study, a defined synthetic co-culture of the cyanobacterium S. elongatus cscB, which feeds the heterotrophic P. putida cscRABY with sucrose, was investigated to identify potential interactions. In initial experiments, a remarkable growth-promoting effect brought about by the presence of the heterotrophic partner on the cyanobacterium was observed, leading to a growth rate increase of up to 80% and increased photosynthetic capacity. Vice versa, the cyanobacterium had a neutral effect on P. putida cscRABY, highlighting the resilience against stress of pseudomonads and their potential as co-culture partners. A suitable reference process reinforcing the growth-promoting effect was established in a parallel operating photobioreactor system, which sets the basis for the analysis of the co-culture at transcriptional, proteomic, and metabolomic level. This multi-OMICs approach revealed several moderate changes, including alterations in the metabolism, transportation, and stress response in both microbes, indicating multi-level interactions. These findings provide valuable insights into the complex dynamics within the co-culture system, suggesting the exchange of further molecules beyond the unidirectional feeding with sucrose.
Targeting the Warburg Effect with Glucosodiene: A Case Report of a 43-year-old Female after Mastectomy of the right breast and axillary clearance with Successful First Case Treatment for Metastatic Triple Negative Breast Cancer (TNBC) of Bone.
Authors: ahmed Amr
Published: August 2023

Breast cancer is the most common type of cancer among women, and triple-negative breast cancer (TNBC) is a particularly aggressive subtype, representing 15-20% of cases. TNBC lacks estrogen, progesterone, and HER2 receptors, making it challenging to treat. This study explores a novel approach by investigating the metabolic pathways in TNBC, focusing on the alkaline glucose isomer, glucosodiene, as a potential therapy. The Warburg effect, discovered in 1924, serves as the basis for this investigation. The case report presents a 42-year-old female patient with TNBC Patient with MRM, Modified radical mastectomy, With axillary clearance., exhibiting a right breast lump with lymph node metastasis. Diagnostic tests confirmed invasive ductal carcinoma GII with negative hormone receptors and HER2/neu. The patient had previously undergone unsuccessful traditional chemotherapy and presented with bone metastasis. Treatment with glucosodiene for 15 days resulted in normal vital functions and no signs of cellular activity. This case study aims to evaluate an individualized treatment plan for TNBC patients and establish effective follow-up protocols. The trial is registered under clinicaltrials.gov number NCT05957939
Conformal dispersion relations for defects and boundaries
Authors: Bianchi Lorenzo , Bonomi Davide
Published: August 2023

We derive a dispersion relation for two-point correlation functions in defect conformal field theories. The correlator is expressed as an integral over a (single) discontinuity that is controlled by the bulk channel operator product expansion (OPE). This very simple relation is particularly useful in perturbative settings where the discontinuity is determined by a subset of bulk operators. In particular, we apply it to holographic correlators of two chiral primary operators in \mathcal{N}=4𝒩=4 Super Yang-Mills theory in the presence of a supersymmetric Wilson line. With a very simple computation, we are able to reproduce and extend existing results. We also propose a second relation, which reconstructs the correlator from a double discontinuity, and is controlled by the defect channel OPE. Finally, for the case of codimension-one defects (boundaries and interfaces) we derive a dispersion relation which receives contributions from both OPE channels and we apply it to the boundary correlator in the O(N) critical model. We reproduce the order \epsilon^2ϵ2 result in the \epsilonϵ-expansion using as input a finite number of boundary CFT data.
Evaluation of the Mandibular Pheromones Produced by Queens of Africanized and European Honeybees under Normal Conditions and During Absconding Processes by HPLC-UV Methodology
Authors: de Almeida Gesline , Chaves Andréa , Queiroz Maria Eugênia , Gramacho Kátia , Gonçalves Lionel
Published: August 2023

Pheromones are essential for colony organization in honeybees. The pheromones 9-ODA ((E)-9-oxodec-2-enoic acid) and 9-HDA ((E)-9-hydroxydec-2-enoic acid), produced by the mandibular gland of the queen, have various functions within the colony, including inhibition of ovarian development of workers, attraction of swarms, and stabilization of the cluster group. An example of reaction of the colony to adverse conditions is absconding, which is defined as mass exit of all of the adult individuals, leaving even brood and food. In this study, the pheromones 9-ODA and 9-HDA were determined in virgin and normal mated, egg-laying European Carniolan and Africanized queens, as well as in mated queens that were in absconding colonies, using liquid chromatography with UV detection developed methodology. Absconding was induced by maintaining free-flying five-standard-Langstroth-frame colonies in a chamber artificially heated to 45 ºC. The obtained results showed that the amount of 9-ODA in Africanized queens (6.56 µg bee-1 ) is very low compared with European queens. However, large amounts of 9-HDA were found in the queens of absconding Africanized swarms (107.4 µg bee-1). According to our results, the quantities of 9-ODA and 9-HDA in Africanized honeybees in Brazil may be contributing to the high rates of absconding, promoting low effect of stabilizing agent, and high effect of attraction of dispersers cluster.
Traditionalism in the Oriental Dimension
Authors:   St. Petersburg State University, Bocharov Viktor V.
Published: August 2023

The article analyzes the concept of “traditionalism”, identified by St. Petersburg scientists as a subject of oriental studies. The need to clarify the status of the discipline arose in connection with its reorientation in the early 2000s to the study of the modern East. If earlier sources for orientalists were written monuments on history, philosophy, law, etc., exported by pioneers and stored in the funds of Europe (London, Paris, Berlin, etc.), as well as St. Petersburg, now the object of research is the living cultures of the East. Ethnography and sociocultural anthropology (ethnology) are also involved in their study. These are related disciplines, however, if the former is more related to, description of the peoples exploring the specific manifestations of ethno-cultural phenomena: customs, rituals, beliefs, symbols, etc., then anthropology with comparative ethnology, the formulation of theoretical and methodological approaches for their study. “Tradition”, from the point of view of the author, since Antiquity has been closely correlated with politics and the aspirations of the elites. In the era of the Enlightenment, this concept acquired an ambivalent content: progressives treated it negatively, considering it an obstacle to the historical development of society, their opponents, on the contrary, believed that it was tradition that ensures the uniqueness of society in the process of its evolution. A similar attitude to tradition is retained in scientific discourse today, it is devoid of scientific content, but is an axiological category. The attitude to tradition is almost the main “bone of contention” in the modern confrontation between East and West. The author proposes an understanding of traditionalism that excludes the absolutization of both universalism (progressivism) and uniqueness in the understanding of tradition, which, from his point of view, corresponds to the principle of scientific character. Keywords: oriental studies, sociocultural anthropology, ethnography, tradition, traditionalism, methodology, the East.
Persian and Russian Names of Textiles Imported to Russia from Iran in the First Half of the 17th Century, as Listed in the Inventories of Goods and Diplomatic Gifts
Authors:   The National Library of Russia, Yastrebova Olga M. ,   St. Petersburg State University
Published: August 2023

The question of the origin and ways of borrowing into the Russian language of the names of oriental fabrics, which were imported in large quantities into Russia in the 17th century, has been attracting attention of scholars for a long time, but synchronous bilingual Persian Russian sources were hardly involved in the study of this issue. The article examines a number of such sources stored in the Russian State Archive of Ancient Acts: these are lists of goods and gifts brought from Safavid Iran by trade and diplomatic representatives of Shah Safi I (1629–1642), accompanied by a Russian translation and stored in f. 77 “Relations between Russia and Persia”. The study of these materials makes it possible to determine the range of fabrics imported on behalf of the Shah, to clarify the meaning and scope of use of a number of Russian and Persian terms, as well as the time of penetration of some borrowed Iranisms into the Russian language. The terms borrowed from Persian and other foreign languages were previously correlated by researchers with specific samples of textiles stored in museum collections. Thanks to this, having established synchronous lexical correspondences, it is possible to more accurately determine what kind of fabrics with what technological features were designated by Persian terms, the definitions of which in the explanatory dictionaries of the Persian language are often contradictory.
Syntax of Mass Media Language in the Context of Historical Development of Turkish Literary Language
Authors:   Lomonosov Moscow State University, Napolnova Elena M. , Verkhova Ksenia A. ,   Lomonosov Moscow State University
Published: August 2023

In the history of Ottoman and modern Turkish literary languages, all the characteristic literary language features of pre-national and national periods respectively (processed, ordered, selection of linguistic means, conscious regulation and codification, etc.) can be traced. The transition from the former to the latter at the beginning of the twentieth century occurred in the form of a linguistic revolution, leading to fundamental changes at different language levels. This still active process is aimed at forming a language norm and creating means that meet the characteristics of individual functional areas of the literary language. Changes in vocabulary are more obvious, better studied and currently focused on creating new, Turkicbased lexemes to replace foreign borrowings. Syntactic changes, no less significant, aim to develop statement structure to facilitate adequate construction and understanding, while maintaining the features of the Turkic system, but these processes are not studied sufficiently. Active formation of the Turkish literary language takes place during a period of rapid development of the media — a functional sphere which occupies a special position due to its wide social base. According to several researchers, the current media language is considered representative of literary languages. This necessitates studying the trends in syntactic structure changes of the Turkish sentence, in order to trace general trends in the development of syntax diachronically, help create a general up-to-date picture of the syntax of the modern literary language, on the basis of a comparative analysis, to determine the main patterns in the development of Turkic syntax, and while teaching Turkish — to concentrate on students’ active acquisition of the most commonly used syntactic means.
Comprehensive evaluation of the effect of regional groundwater overexploitation restoration
Authors: Ling Minhua , Chen Jiangyu , Liu Fei , Yu Lili , Li Fengkai , Xia Qinyuan
Published: August 2023

The traditional groundwater overexploitation restoration only considers the impact on groundwater, on the basis of which, this paper also comprehensively considers the impact on economic society and the ecological environment. Based on analyzing the effect of groundwater overexploitation restoration on the groundwater–economic society–ecological environment (GESEE) system, an evaluation indicator system covering the GESEE system was constructed, an evaluation method for the effect of groundwater overexploitation restoration was established, and the effects were evaluated for Hebei Province, China, from 2014 to 2019. The results showed that the effect of groundwater overexploitation restoration in Hebei Province was obvious, and the grade of the groundwater overexploitation restoration effect improved from fair to good. The grade of the groundwater overexploitation restoration effect in most cities was improved to good. The measures that most affected the effect of groundwater overexploitation restoration in Hebei Province are strict control of extraction and reduction of consumption, while measures such as the replacement of water sources also play a significant role. An evaluation indicator system constructed in this paper can help to promote sophisticated effect evaluation of groundwater overexploitation restoration and improve the understanding and management of groundwater overexploitation restoration.
Surveillance of Naegleria fowleri in Louisiana's public water systems
Authors: Ward Lauren , Sherchan Samendra P.
Published: August 2023

The free-living amoeba Naegleria fowleri (Nf) inhabits soil and natural waters worldwide: it is thermophilic and thrives at temperatures up to 45 °C and in a multitude of environments. Three deaths in Louisiana were attributed to primary amoebic meningoencephalitis (PAM) caused by Nf infection in 2011 and 2013. Following these incidents, public water systems are now monitored for the presence of Nf in Louisiana. From 2014 to 2018, 29% (27/93) of samples collected showed positive for Nf and 68% (63/93) showed all thermophilic amoeba culture. Ten raw water sources and 17 distribution water systems tested positive. The year 2017 showed the highest number of samples with Nf (n = 10) followed by nine samples in 2015. As climate change increases surface water temperatures, continued testing for Nf prevalence will be an important facet of water monitoring and will need to extend into locations farther north than the current most common range.
Renewable Energy in International Law: The Russian Perspective for Developing a Common BRICS Approach
Authors: Vylegzhanin A. , Ivanov D. , Milyukova M.
Published: August 2023

The growing inﬂuence of renewable energy in the economy raises concerns about the need for perfecting the relevant international legal regime so as to satisfy all the stakeholders concerned. This article analyzes the relevant legal position of Russia as one of the largest exporters of energy-related products, while focusing on cooperation in this area as the BRICS Energy Prospects. The research reveals a number of ﬁndings: Russian Energy Policy has so far cautiously supported the promotion of renewable energy internationally in the context of energy eﬃciency and energy security; nevertheless, Russia has demonstrated a very restrained approach to the development of legally binding instruments on the matter. The authors conclude that it may be viable to ﬁnd a reasonable “compromise of compromises” for the evolving international legal regime of renewable energy, and if this were to be accomplished, BRICS could assume a leading international position for the creation of such a regime.
N-unsubstituted Imidazoles: Design, Synthesis, and Antimicrobial Evaluation
Authors: Davood Asghar , EbrahimiNassimi Yassamin , Sardari Soroush , Farahani Yekta Farmahini
Published: August 2023

Background:

All the current antifungal azoles have one substituted nitrogen atom in their imidazole
or triazole rings. In this study, eleven imine and amine derivatives of imidazole, in which both nitrogen atoms
of the imidazole ring are unsubstituted, were designed and synthesized.

Materials and Methods:

Imine derivatives were prepared by condensation of imidazole-4-carboxaldehyde with
appropriate amines, and then in the next step, using sodium borohydride, the imines were reduced to amine derivatives.
Docking studies reveal unsubstituted nitrogen atom of the imidazole ring coordinated well with the
heme molecule of the receptor. In vitro, antimicrobial evaluation was tested on Candida albicans, E. coli, and
Staphylococcus aureus.

Results:

Based on the results of the antimicrobial study, compound 10, which contains 4-chlorobenzyl moiety,
proved to be the most potent compound against Candida albicans, and it was more active than the reference
drug fluconazole and showed comparable activity to amphotericin B. Compounds 10 and 11 and compounds 8,
10 and 11 showed significant responses against E. coli and Staphylococcus aureus respectively.

Conclusion:

It is concluded that compound 10 can be acted as a new lead compound to find new azoles antifungal.
Revolutionizing Pharmaceutical Industry: The Radical Impact of Artificial
Intelligence and Machine Learning
Authors: Chhina Aashveen , Trehan Karan , Saini Muskaan , Thakur Shubham , Kaur Manjot , Shahtaghi Navid Reza , Shivgotra Riya , Soni Bindu , Modi Anuj , Bakrey Hossamaldeen , Jain Subheet Kumar
Published: August 2023

This article explores the significant impact of artificial intelligence (AI) and machine learning (ML)
on the pharmaceutical industry, which has transformed the drug development process. AI and ML technologies
provide powerful tools for analysis, decision-making, and prediction by simplifying complex procedures from
drug design to formulation design. These techniques could potentially speed up the development of better medications
and drug development processes, improving the lives of millions of people. However, the use of these
techniques requires trained personnel and human surveillance for AI to function effectively, if not there is a possibility
of errors like security breaches of personal data and bias can also occur. Thus, the present review article
discusses the transformative power of AI and ML in the pharmaceutical industry and provides insights into the
future of drug development and patient care.
Impact of Phytomolecules with Nanotechnology on the Treatment of
Inflammation
Authors: Singh Sonia , Semwal Bhupesh C , Sharma Himanshu , Sharma Divya
Published: August 2023

Inflammation is a part of the biological response of body tissues against harmful stimuli,
such as damaged cells, pathogens, irradiations, and toxic compounds. Numerous treatments, including
anti-inflammatory drugs that treat the condition of inflammation, are available for its management.
Because of the severe adverse effects associated with synthetic medications, phytotherapy
may be a promising and effective approach to treating inflammation. The therapeutic potential of
herbs is due to their capacity to target a variety of inflammatory mediators, including chemokines,
cytokines, nitric oxide, lipoxygenase, nuclear factor kappa-B, and arachidonic acid. Furthermore,
nanomedicine may be a valuable and effective formulation approach for overcoming the drawbacks
of phytoconstituents, such as their low bioavailability, high first-pass metabolism, and poor stability.
The current manuscript provides a thorough description of many phytoconstituents and herbal
plants that have great potential for treating inflammation-related diseases, as well as information on
their limitations, drug formulations, and regulatory issues.