bluuebunny/crossref_metadata_2025 huggingface dataset:
Relação entre compartilhamento do conhecimento e socialização organizacional em instituições de ensino superior
Authors: Crocetta Schraiber Fernanda , Gualberto Bacelar da Cruz Urpia Arthur
Published: June 2022

Este artigo apresenta uma revisão sistemática da literatura referente ao Compartilhamento do Conhecimento e a Socialização Organizacional em Instituições de Ensino Superior (IES). O levantamento das publicações foi realizado em três bases de dados (Capes, Scielo e Dimensions) conduzido pelas seguintes questões norteadoras: como ocorre a socialização organizacional em IES? Como o Compartilhamento do Conhecimento em IES contribui para o processo de Socialização Organizacional? Para responder a essas questões, utilizando-se do método Systematic-Search Flow (SSF) - uma vez que esse sistematiza o processo de busca e garante a repetibilidade, além de focar na pesquisa exaustiva sobre o tema - foram selecionados estudos publicados entre fevereiro de 2010 a fevereiro de 2020. Para compor o corpus de análise de revisão, obteve-se 17 artigos. Verificou-se que, embora o Compartilhamento do Conhecimento e a Socialização Organizacional sejam termos usados com frequência na literatura nacional e internacional, pesquisas que analisem a relação entre ambos são escassas, sendo encontrados somente dois resultados, dos quais nenhum abordava especificamente a associação dos conceitos com IES.
DIZARTRIYA NUTQ KAMCHILIGIGA EGA BOLALAR NUTQI USTIDA ISHLASHNING SAMARALI USULLARI VA INNOVATSION TEXNOLOGIYALARI
Authors: ACHILOVA Sevara
Published: June 2022

Ushbu maqolada dizartriya nutq kamchiligiga ega bolalar nutqi ustida ishlashning samarali usullari va innovatsion texnologiyalari aytib o'tilgan. Shuningdek, qo'llaniladigan texnologiyalarning olib borilishi va natijalari ochib berilgan.
Upgrading: An Analysis of Financial Aids and Academic Performance at Qatar University
Authors: Al-Kubaisi Huda
Published: June 2022

The significant financial allocations invested in supporting students academically denotes the importance attached to the impact of these allocations. This study provided explanatory insights into the contribution of financial aids to students’ performance. An analysis of 109 QU students was conducted using a two-approach quantitative method. Significant differences exist in the academic performance of both groups in favor of the beneficiaries, especially based on the financial support type to the advantage of the ‘merit-based aids’. Gender, however, does not significantly influence financial aid delivery. According to the findings, policymakers, financial decision-makers and educators can improve students’ low academic performance by sharing best practices.
Why We Need a New Eco-Social Contract
Authors: Kempf Isabell , Hujo Katja , Ponte Rafael
Published: June 2022

Calls for new economic and social approaches to combine social and climate justice have become louder and more urgent in light of the current COVID-19 and climate crises. The need to address inequalities, exploitation of people, and lacking respect for the natural boundaries of our planet have led to new approaches such as just transition, wellbeing economics or a new eco-social contract. This article will show why a new eco-social contract needs to combine social and climate justice and what we can learn from an analysis and the comparison of the different visions regarding such a contract.
A Correlation between Students’ Self-Esteem and Speaking Skill
Authors: Sartika Dewi -
Published: June 2022

The aim of learning English was to develop students’ competence in oral and written communication to research the functional literacy stated in the 2013 Curriculum. This study investigated the link between students' self-esteem and their speaking skills. It employed correlational study. A questionnaire and an oral test were employed to collect data. A questionnaire was utilized to assess the students' self-esteem, and an oral test was employed to assess their speaking abilities. The eleventh graders at SMAN 5 Ogan Komering Ilir were the focus of this study. 103 students selected as a sample from a population of 172. A Pearson Product Moment Correlation method was used to examine the data. The study's findings revealed that r-obtained (0.644) was greater than r-table (0.194) when the p-value (0.000) was less than 0.05. It meant that the null hypothesis (Ho) had been rejected and that the alternative hypothesis (Ho) had been accepted. In other words, there was a link between students' self-esteem and their ability to communicate. It is possible that learners' self-esteem influenced their speaking abilities. As a result, the higher the learners' self-esteem, the better their speaking abilities.
The Team Teachers' Beliefs about Their Roles in Collaborative Team Teaching in Indonesia Context
Authors: Nuraini Eka Indah
Published: June 2022

This study aims to report the results of qualitative research using a case study design on the team teachers’ beliefs about their roles in collaborative team teaching between native-English speaking teachers (NESTs) and local English teachers (LETs) in Indonesian secondary schools and aspects that shape their beliefs. Two pairs of English team teachers at two Junior High Schools in Ponorogo were interviewed and their classroom practices were observed. Then, the data were analyzed by using the interactive model proposed by Miles Huberman. The findings showed that NESTs and LETs possessed different beliefs about their roles in team teaching in which NESTs perceived their roles primarily dealing with linguistic and cultural aspects. Meanwhile, LETs played roles as the main teachers who led the classes by writing lesson plans, choosing the materials, focusing on theory (delivering basic materials), and assessing students. Furthermore, three factors shape teachers’ beliefs about their roles in team teaching, namely training, teaching experience, and learning experience. This research findings are expected to provide some recommendations to wide range of stakeholders to re-examine the practice of team teaching between NESTs and LETs by focusing on their respective strengths to generate the best classroom practices.
violência sexual infanto-juvenil e o atendimento no estado do Rio Grande do Sul
Authors: Custódio André Viana , Cassionato Andréa Silva Albas Cassionato
Published: June 2022

O presente artigo trata da violência sexual contra crianças e adolescentes e da elaboração de protocolos e fluxos de atendimento das vítimas no Estado do Rio Grande do Sul. Para tanto, estabeleceu-se o marco jurídico da proteção de crianças e adolescentes contra a violência sexual, constitucional e estatutária, bem como foi demonstrada a distinção entre abuso e exploração sexual. Posteriormente, desenvolveu-se estudo sobre a política de atendimento das vítimas com destaque para a importância da intersetorialidade, do atendimento sanitário e do atendimento socioassistencial. Por fim, tratou-se dos fluxos de atendimento no Estado do Rio Grande do Sul mediante o contexto das crianças e adolescentes vítimas de violência sexual, dos protocolos e fluxos adotados pelo Governo do Estado e da percepção e contribuições dos profissionais que atuam na rede de atendimento para seu aprimoramento. O método de abordagem foi dedutivo e o método de procedimento monográfico com técnicas de pesquisa bibliográfica e documental. Os principais resultados consistiram na constatação de que houve o aumento das notificações de violência sexual conforme informações do Sistema de Informação de Agravos de Notificação - SINAN, de tal maneira que se concluiu que o Estado do Rio Grande do Sul não promoveu, até o ano de 2019, qualquer avanço no combate à violência sexual infanto-juvenil. Além disso, concluiu-se que não existe um protocolo de atendimento unificado para o Estado, restando aos profissionais da rede agirem conforme sua tradição e cultura.
Konstrukcje semantyczno-składniowe z czasownikiem „czuć”. Uwagi na marginesie gramatyki konstrukcji i kognitywizmu
Authors: Nowakowska-Kempna Iwona , Camm Sandra
Published: June 2022

The article concentrates on the concept of CZUĆ (FEEL) in Polish as it underlies semantico-syntactic constructions and emerges as the auxiliary verb czuć. The authors discuss essential meanings of the concept and analyse those phrasal and clausal constructions which are based on the verb czuć. Consequently, they characterize the way the verb is understood and explain how its meanings are constructed. Finally, the article shows how the sensory meanings of the verb czuć have been extended to the emotional and cognitive meanings of premonitions and presumptions.
Z badań frazeologii we współczesnej prasie katolickiej. Frazeologia w tygodniku „Niedziela”
Authors: Wysoczański Włodzimierz
Published: June 2022

The article concerns the functioning of phraseology in the weekly Niedziela in two main dimensions. Firstly, the analysis focuses on revealing the correctness of using the phraseological resource available in the Polish language regarding the aspects and ways of introducing phraseologisms into the magazine. The second research area relates to the specificity of the application and contexts in which phraseology occurs, aiming at distinguishing more important problem circles along with the interpretative regularities of the reality presented through the prism of phraseology. A more complete overview covers the spheres of faith, religion and the sacred as well as the ethical-moral and axiological levels. The detected properties of the phraseology in the weekly Niedziela are in line with the research on phraseology in contemporary Catholic press.
Gestão do Doente COVID-19 na Rede Nacional de Cuidados Continuados Integrados: A Perspetiva do Médico Paliativista
Authors: Ribeiro João , Pinto-Ribeiro Filipa , Nunes Rui
Published: June 2022

N/a.
Correction to the article “Prevalence of the Most Frequent Neuropsychiatric Diagnoses in Hospitalized SARS-CoV-2 Patients Evaluated by Liaison Psychiatry: Cross-Sectional Study”, Published on Acta Med Port 2022 Jun;35(6):425-432.
Authors: Editorial2 Departamento
Published: June 2022

On page 428, Table 2, column p-value and in the Table description, where it reads:0.6150.4840.3730.6840.5110.5350.4100.64410.020.1160.0450.370It should read (in bold):0.615**0.684**0.373**0.684**0.511**0.535**0.410**0.644††1**0.02**0.116**0.045‡ 0.370‡On the same page, same Table, on the description of the table, where it reads:‡‡: Risk factors for severe COVID-19 illness as defined by CDC in March 202015; §: Severe cardiovascular disease, including congestive heart failure, coronary artery disease orcardiomyopathy; § §: Presence of any of the previous risk factors; ||: Cough, dyspnoea, and fever; †: Admission to intensive care unit (ICU) during hospitalisation; **: Chi-squared test;††: Fisher’s Exact test.It should read:‡‡: risk factors for severe COVID-19 illness as defined by CDC in March 202015; §: severe cardiovascular disease, including congestive heart failure, coronary artery disease or cardiomyopathy; § §: presence of any of the previous risk factors; ||: cough, dyspnoea, and fever; †: admission to intensive care unit (ICU) during hospitalisation; **: chi-square test;††: Fisher’s Exact test; ‡: Mann-Whitney testArticle published with errors:https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/16410
Comparative Analysis of Households and Digital Currencies for the US, China and Russia
Authors: Wang Guizhou , Hausken Kjell
Published: June 2022

In a two-period decision model, a central bank chooses a CBDC (central bank digital currency) interest rate and a representative household allocates resources into production, consumption, CBDC holding, and non-CBDC holding. The model’s analytical results and a plausible benchmark are compared with the empirics for the US, China and Russia. Interesting novelties of the article are that the model predicts that the US in 2021/2022 should choose  rather than 0.125% CBDC interest to combat its high October 2021 empirical inflation of 6.2%. That would induce households to hold more CBDC, hold less non-CBDC, and produce and consume less. In contrast, the model predicts that China should choose a low  rather than  CBDC interest rate. That would decrease each household’s CBDC holding and increase the low inflation. The model predicts that Russia should choose  rather than  CBDC interest rate. Russia’s strategy is remarkably consistent with the model’s predictions. The model predicts that the central bank should choose negative CBDC interest rate when the inflation and real interest rate are low, and the inflation target is high. The article shows how extremely high inflation, which increases the CBDC interest rate, makes production and consumption nearly impossible, unless the real interest rate is extremely negative.
Leverage, profitability, corporate governance mecanism and earning management: cases in manufacturing company in Indonesia Stock Exchange
Authors: Prawida Novria , Sutrisno Sutrisno
Published: June 2022

Earnings management is a form of manager manipulation in company external financial report in aim for individual profit. This research aim to analyze leverage efek, profitability, the amount of commissioner board and audit committee towards earnings management in bank that registered in BEI 2016-2017. This research is quantitative research and the sample conducted with purposive sampling method. This research apply secondary resource data from annual financial report of registered bank in BEI 2016-2017. There are 32 bank that fulfill criteria that researcher submit. This research apply multiple linier regression analysis method using IBM SPSS program. The results shows that leverage (DAR) has positive significant effect towards earnings management, profitability (ROA) doesn’t have significant effect towards earnings management, amount of commissioner board (BS) and audit committee (KA) doesn’t have significant effect toward earnings management.
Do Islamic stock indexes integrated with conventional stock indexes?: Evidence from Indonesia and Malaysia
Authors: Rusmita Sylva Alif , Swastika Putri
Published: June 2022

The portfolios performance that are develop either a substitute or complement in terms of risk-taking is important information for investors whether the return portfolio could hedge the risk of shock market. An understanding of volatility and the correlation between asset returns over time vary is highly important for investors (both domestic and international) with the sight of diversifying their portfolios for hedging from unexpected risk. The research method uses a DCC MGARCH approach to examine the correlation among two countries in time variant manner to indicate the degree of financial integration. With daily data from April 2012 until December 2017 and use 3 category index (composite, Islamic and conventional) the result shows that Malaysia and Indonesia have strong correlation. Among Islamic, composite and conventional have financial integration, but conventional index in Malaysia have the lowest integration from other index that it makes suitable for diversification. Unfortunately, conventional index that contain non halal product was not suitable for investor that sharp pointed into sharia. The shock in Malaysia’s Index will be perform different from historical or previous return. Contrary with Indonesia’s index, the return probably based on the historical. The implication of this research is we found that the Islamic investor could not have best diversification on the Malaysia and Indonesia market, since the Islamic index was sturdily correlated.
The relationship between consumer buying behavior, social aspects, and technostress on smartphone
Authors: Hadi Antonius Satria
Published: June 2022

The objectives of this study is to investigate the influence of social aspects including social need and social influence toward dependency, the influence of dependency toward repeat purchase intention and technostress. Respondents in this research were 200 undergraduate students from universities in Yogyakarta, Indonesia. This research has four hypotheses. The analytical technique used in this research were Confirmatory Factor Analysis (CFA) and Structural Equation Model (SEM) using LISREL 10 software. The results of this research empirically proves that social aspects including social need and social influence has significant and positive effect toward dependency, and dependency has significant and positive effect toward repeat purchase intention and technostress. Each of hypotheses were accepted and elaborated more detail in discussion section.
PELUANG DAN TANTANGAN INSTITUSI PENDIDIKAN EKONOMI ISLAM DALAM KONTEKS TREND EKONOMI GLOBAL
Authors: Kholis Nur
Published: June 2022

The development of Islamic economy is currently very rapidly in Indonesia, particularly Islamic banking. Of course, this is due to start his conscious development of the community against the adverse effects of western capitalist economies. Even though, so the high growth of Islamic banking is not accompanied by high quality human resources. This paper tries to dig deeper into the role of institutions and educational institutions in preparing human resources "insani". Prepared with human resources are good then the sharia Islamic economy will be able to exist and grow amid a global economy.
TINGKAT EFISIENSI PERBANKAN SYARIAH DAN KONVENSIONAL DENGAN MENGUNAKAN DATA ENVELOPMENT ANALYSIS (DEA)
Authors: Ferari Nico , Sudarsono Heri
Published: June 2022

This research utilizesa non-parametric frontier approach, Data Envelopment Analysis (DEA). By using such an analysis, the purpose of this study is to analyse 3 Islamic banks in Indonesia during 2007-2010 period. In general, the result of study indicates that the level of efficiency of Islamic bank is various moving over time. In intermediary efficiency, conventional bank is found to be more efficient than Islamic bank. Moreover, conventional bank is more efficient than Islamic bank. Since the study pinpoints the sources of inefficiency, it also helps to provide the banks with strategic planning
DETERMINAN KINERJA SISTEM INFORMASI AKUNTANSI: STUDI EMPIRIS PADA BANK SYARIAH DI WILAYAH DAERAH ISTIMEWA YOGYAKARTA
Authors: Marfuah Marfuah , Handoko Akbar
Published: June 2022

This research is aim to analyze factors affecting the performance of accounting information system (SIA) of Islamic Banks in Daerah Istimewa Yogyakarta (DIY). The variables that are expected to influence SIA including the existence of monitoring board, formalization of information system, top management support, user involvement, technical skill of staff, organization size, training and education program, location of information system department, communication between user and developer, and user conflict . As many as 65 respondents were taken from 3 Islam banks in DIY. The research findings show that there are 6 variables that significantly influencing the performance of SIA, namely: the existence o fmonitoring board, top management support, user involvement, technical skill of staff, organization size, training and education program, location of information system department, communication between user and developer. Meanwhile, user conflict variable has negative influence on the performace of SIA. Formalization of information system variable and organization size variable have no influence on the performance of SIA.
Faktor-faktor yang mempengaruhi deposito mudharabah pada bank syariah di Indonesia
Authors: Juniarty Nila , Mifrahi Mustika Noor , Tohirin Achmad
Published: June 2022

Mudharabah Deposit is one of Islamic banking products, which is the biggest contributor to sharia banking compared to other collecting products. In addition, according to Bank Indonesia's report, the number of Islamic banking deposits each year has increased significantly. Therefore, in this study, the authors want to know the factors that are expected to affect the number of mudharabah deposits. There are 6 factors that are expected to affect the number of deposits, namely the profit-sharing rate, the interest rate, the promotion rate, the inflation rate, the FDR, and the number of offices. The authors use a weighted average in terms of rate of profit sharing and interest rate and data processing using multiple linear regression. The results of these regression calculations, simultaneously show positive and significant results for all variables. This value resulted from the four regression has a value of sig-F 0.000 is smaller than 10% significance. Partially, profit sharing, promotion cost and number of offices show significant and positive effect on total mudharabah deposit, while interest rate, inflation and FDR show no effect on mudharabah deposit amount.
Energy Production Estimation and Data Monitoring System In 300 kWp Rooftop Solar Power Plant XYZ, Inc.
Authors: Illahi Geovani Rahmad , Iftadi Irwan , Ramelan Agus
Published: June 2022

One of the greatest potential for renewable energy comes from solar energy. In Indonesia, the potential for solar energy can reach 3.294 GWP. This amount is very large when compared to other renewable energy production potentials. However, the problem with the solar power plant system is that the production of energy produced is influenced by time, weather, location, and the efficiency of the system can affect energy. This study discusses from the design process, estimation of energy production, and monitoring data on PV mini-grid. The calculation is done by estimation using PVsyst software. The monitoring system is made based on the specifications used. The design of this system is made to record data by measuring performance ratio and also calculating the efficiency of the system.
Markov Cluster Algorithm Based Intra and Inter Cell Interference Management in 5g Wireless Mesh Networks
Authors: Benni Nirmalkumar , Manvi Sunilkumar
Published: June 2022

Due to the decreasing distance between cells, inter and intra cell interference management become more challenging in ultra-highly dense small cell cellular networks. The main objective of our research is to manage the inter-cell and intra-cell interferences in a cellular network. Initially, the inter-cell interference is eliminated by creating an interference-weighted graph and cell clustering of cellular networks. The user clustering process is fundamental for the cell clustering process. The markov clustering algorithm (MCA) is proposed to achieve cell clustering in the cellular network. The intra-cell interference is eliminated by allocating a channel to the user based on the markov model. The channel allocation is done using the markov prediction model, which effectively predicts the best optimal channel for each user in the cells. This prediction process dramatically reduces the channel selection timing during the clustering-based interference management process. The simulation is done using the MatLab platform. The performance parameters used by our proposed method are throughput, SINR (Signal-to-Interferenceplus-Noise-Ratio), bit error rate (BER), sum rate, total energy consumption, and cumulative distribution function (CDF). The robustness and proficiency of our system are represented by comparing various existing methods like resource availability maximization function (RAmax), almost blank subframe (ABS), and channel aggregation (CA) techniques.
Synthesis and characterization of TiO2/ZnO heterostructure for UV photocatalytic degrade DOM in landfill leachate
Authors: Li Bicai , Yuan Donghai , Gao Caiyun , Zhang Hong , Li Zhicheng
Published: June 2022

TiO2/ZnO heterostructure photocatalysts were successfully fabricated via hydrothermal and solid-state reaction method. In TiO2/ZnO composite powder, TiO2 nanoparticles of anatase phase are well distributed on the surface and edge of ZnO with wurtzite phase structure, and closely combined to form heterostructure. The optical bandgap of TiO2/ZnO powder is less than that of pure ZnO or TiO2 powder. TiO2/ZnO composite powders show higher degradation efficiency for methylene blue and dissolved organic matter. The degradation rate of TiO2/ZnO powder for fulvic acid-like substances in landfill leachate is 2.99 times that of pure ZnO powder and 1.30 times that of pure TiO2 powder. The degradation of fulvic acid-like substances by photocatalyst causes the decrease of some high molecular weight and benzene ring structure substances in leachate. The effective separation of electron and hole by the heterostructure in TiO2/ZnO powder is the main reason for its high photocatalytic degradation efficiency of DOM in landfill leachate.
Synthesis and anti-influenza virus activity evaluation of novel andrographolide derivatives
Authors: Zou Chunyang , Men Jinyu , Qu Yingjin , Jiang Chunfeng , Wang Yao , Chen Lixia , Yuan Lei
Published: June 2022

In this paper, using AI78-38, an andrographolide analog with novel skeleton, as the lead compound, we designed and synthesized fifteen amide derivatives at the 17 position of AI78-38. In the synthesis of key intermediate IM4, the low yield of the SeO2 oxidation step impeded the further study. Aiming at improving the yield, White reagent was applied to furnish IM4 by catalyzing the allylic C–H oxidation at the 7, 8, 17 position. It is also firstly reported that White reagent possessed the ability of oxidating the cyclic substrates. Compared with SeO2 oxidative approach, the modified synthetic method utilized by White reagent increased the yield from 32.0% to 53.6%. The anti-influenza A virus (H3N2) results showed that 4-methoxy derivative 10 offered the greatest inhibitory ability, with an IC50 value of 90.2 mg/ml, slightly more potent than ribavirin. Furthermore, the drug likeness and ADMET properties of compound 10 and AI78-38 were evaluated using the Discovery Studio 2.1 software and the online SwissADME. The results showed that compound 10 offered good bioavailability and overcame the disadvantages of the ADMET properties in AI78-38.
Efficacy of belimumab combined with rituximab in severe systemic lupus erythematosus: study protocol for the phase 3, multicenter, randomized, open-label Synbiose 2 trial
Authors: Schaik Mieke van , Arends Eline J. , Soonawala Darius , Ommen Ellen van , de Leeuw Karina , Limper Maarten , Paassen Pieter van , Huizinga Tom W.J. , Toes René E.M. , Kooten Cees van , Rotmans Joris I. , Rabelink Ton J. , Teng Y.K. Onno
Published: June 2022

Introduction: Belimumab, an anti-B-cell activating factor antibody, is approved for the treatment of auto-antibody positive systemic lupus erythematosus with a high degree of disease activity. Anti-CD20 B cell depletion with rituximab is used in refractory SLE as well, although with variable responses. We hypothesized that incomplete B cell depletion, related to a surge in BAFF levels following rituximab treatment, can cause ongoing disease activity and flares. The Synbiose 1 study primarily focused on immunological effects and shows preliminary clinical benefit of combined rituximab and belimumab in SLE. The Synbiose 2 study will evaluate the clinical efficacy of combining belimumab with rituximab in patients with severe SLE, allowing tapering of prednisolone and mycophenolate. Methods and analysis Synbiose 2 is a phase 3, multicenter, randomized, controlled, open-label two year clinical trial. Seventy adults with severe SLE including lupus nephritis will be randomized 1:1 to receive either standard of care consisting of prednisolone and mycophenolate as induction and maintenance treatment, or belimumab and rituximab combined with standard of care as induction treatment, followed by prednisolone and belimumab as maintenance treatment. The primary objective is to assess whether combined B cell therapy will lead to a reduction of treatment failure. Secondary endpoints are complete and partial clinical and renal response, and the improvement of SLE-specific autoimmune phenomena. Safety endpoints include the incidence of adverse events, with special interest in infections. Discussion The Synbiose 2 trial is the first multicenter phase 3 clinical trial investigating combined B cell targeted therapy in SLE, including lupus nephritis. The outcome of this study will provide further evidence for the clinical efficacy of this new treatment strategy in severe SLE. Trial registration Clinical Trials, NCT03747159, Registered November 20, 2018; https://clinicaltrials.gov/ct2/show/NCT03747159
A Comprehensive Analysis Revealing NEK2 as an oncogene in the Tumor Microenvironment
Authors: Jiang Lin-hong , Li Lei , Yang Kai , Wang Dan-dan , Xu Wen-xiu , Yang Su-jin , Chen Xiu , Tang Jin-hai , Zhang He-Da
Published: June 2022

Background
Never in Mitosis (NIMA)-related kinase 2 (Nek2), a member of the serine/threonine kinase family, localizes to centrosomes/kinetochores, which was involved in mitotic regulation. However, the clinical significance and the role of NEK2 in various cancers remained largely elusive.
Methods
ONCOMINE, Tumor Immune Estimation Resource (TIMER), Kaplan-Meier plotter database, UALCAN, GeneMANIA, String and CancerSEA Analysis were used to fully evaluate the clinical value of NEK2
Results
NEK2 was meaningfully up-regulated in the vast majority of cancers, however, the prognostic significance of NEK2 was only associated with the patients with breast cancer, lung cancer, liver cancer, renal carcinoma, pancreatic ductal adenocarcinoma, sarcoma and thyroid carcinoma. Furthermore, NEK2 expression was also correlated with individual pathological cancer stages. In addition, NEK2 participated in regulating the tumor immunity. Enrichment analysis and functional state showed NEK2 was involved in the cell cycle.
Conclusions
These findings interpret the clinic value of NEK2 in a variety of cancers, which may be a novel biomarker and therapeutic target.
Mid-term Evaluation of Maternal and Child Nutrition Programme (MCNP II) in Kenya
Authors: Codjia Patrick , Kutondo Edward , Kamudoni Penjani , Munga Judith , Ahluwalia Aneesha , Sharma Indrani , de Jong Yvon , Amolo Tom , Maina Lucy , Mwenda Victoria , Chaudhry Hemant , Bukania Zipporah
Published: June 2022

Background: Kenya is still facing a triple burden of malnutrition. Malnutrition in Kenya is multi-faceted in nature with health and socio-economic implications. Huge geographical disparities exist, especially, in the arid and semi-arid lands, further exacerbated by factors such as inadequate funding allocation to nutrition sector, challenges in multi-sectoral coordination and nutrition governance. UNICEF’s Maternal and Child Nutrition Program (MCNP II) is a four-year (2018-2022) resilience building, multi-sectoral program focused on pregnant and lactating women, mothers of children under five years and children under five years. The objective of this mid-term evaluation was to establish relevance, effectiveness, efficiency, and sustainability of the programme. Methods: The study adopted a concurrent mixed methods approach, where qualitative information was gathered through key informant interviews, focus group discussions and quantitative data obtained through desk review of secondary data from various sources. Qualitative information was organized using Nvivo software and analyzed thematically, while descriptive analysis for the quantitative data was undertaken using EXCEL software. Results: The findings show that MCNP II programme has aligned its efforts to the nutrition situation in Kenya as well as to the Government of Kenya and donor priorities. Most of the planned programme targets were achieved despite operating in COVID-19 pandemic environment. The use of approaches such as family mid-upper arm circumference (MUAC), integrated management of acute malnutrition (IMAM) surge model, Malezi bora and Logistic Management Information Management System have contributed to realization of results. Stringent financial management strategies contributed towards programme efficiencies; however, optimal utilization of the resources needs further strengthening. The programme has adopted strategies for strengthening local capacity and promote ownership.Conclusion: The programme is on track across the four evaluation criteria. However, a few suggestions are recommended to improve relevance, effectiveness, efficiency, and sustainability. A formal transition strategy needs to be developed in consultation with multi-stakeholder groups and implemented in phases. UNICEF can explore ‘Delivering as One approach’ and gender transformative approaches with more systematic involvement of males and females in gender-based discussions.
Contrast-enhanced MRI-based radiomics signatures as new markers for preoperative assessment of the EGFR mutation and subtypes from bone metastases
Authors: Fan Ying , Dong Yue , Sun Xinyan , Wang Huan , Zhao Peng , Wang Hongbo , Jiang Xiran
Published: June 2022

Background
To develop and externally validate contrast-enhanced (CE) T1-weighted MRI-based radiomics for the identification of epidermal growth factor receptor (EGFR) mutation, exon-19 deletion and exon-21 L858R mutation with the spinal bone metastasis from primary lung adenocarcinoma.
Methods
The study enrolled 159 patients from our hospital between Jan. 2017 and Sep. 2021 to form a primary set, and 24 patients from another center between Jan. 2017 and Oct. 2021 to form an independent validation set. Radiomics features were extracted from the CET1 MRI using the Pyradiomics method. The least absolute shrinkage and selection operator (LASSO) regression was applied for selecting the most predictive features. Radiomics signatures (RSs) were developed based on the primary training set to predict the EGFR mutation and to differentiate the exon-19 deletion and exon-21 L858R. The RSs were validated on the internal and external validation sets using the ROC curve analysis.
Results
A total of 8, 3 and 5 most predictive features were selected to build the RS-EGFR, RS-19 and RS-21 for predicting the EGFR mutation, exon-19 deletion and exon-21 L858R, respectively. The RSs generated favorable prediction efficacies on the primary (AUCs, RS-EGFR vs. RS-19 vs. RS-21, 0.851 vs. 0.816 vs. 0.814) and external validation (AUCs, RS-EGFR vs. RS-19 vs. RS-21, 0.807 vs. 0.742 vs. 0.792) sets.
Conclusions
Radiomics features from the contrast-enhanced MRI could be used to detect the EGFR mutation, increase the certainty of identifying exon-19 deletion and exon-21 L858R mutations based on the spinal metastasis.
Analysis of phase stability, elastic, electronic, thermal, and optical properties of Sc1-xYxN via ab initio methods
Authors: Gagui Souheyla , Meradji Hocine , Ghemid Sebti , Naeem Samia , Haq Bakhtiar Ul , Ahmed Rashid , Kushwaha A.k.
Published: June 2022

Understanding the physical properties of a material is crucial to know its applicability for practical applications. In this study, we investigate the phase stability, elastic, electronic, thermal, and optical properties of the ternary alloying of the scandium and yttrium nitrides (Sc1 − xYxN) for different compositions. To do so, we apply a “density functional theory (DFT)” based scheme of calculations named as “full potential (FP) linearized (L) augmented plane wave plus local orbitals (APW + lo) method" realized in the WIEN2k computational package. At first, the phase stability of the investigated compositions of the mentioned alloy is determined. The analysis of our calculations shows that Sc1 − xYxN alloy is stable in rock salt crystal structure for all investigated compositions. Next to that, the elastic properties of the rock-salt phase of the studied ternary alloy Sc1 − xYxN at all above said compositions were done at the level of “Wu-Cohen generalized gradient approximation (Wu-GGA)” within DFT. However, Trans-Blaha (TB) approximation of the “modified Becke-Johson (mBJ)” potential is also used in combination with Wu-GGA where the thermal properties are calculated at the level of the "quasi-harmonic Debye model". The obtained results for the absorption coefficients, and optical bandgap, represent that the title alloy may be a suitable candidate for the applications in optoelectronic devices.
Illumination system optimal design for geometry measurement of complex cutting tools in machine vision
Authors: Wang Wenqi , Liu Wei , Zhang Yang , Zhang Peidong , Si Likun , Zhou Mengde
Published: June 2022

Precision geometry measurement of the complex cutting tools has a significant impact on the machinability of components in the industry. However, acquisition of high-quality images in machine vision is a challenging problem due to the large slope and complex geometry of the cutting tools. In view of the vital function of illumination, this paper proposed a method of optimal design for the LEDs array. First, the calculation model of irradiance distribution on the measurement plane is established and the properties of the reflected light from the surface of cutting tools is analysed based on the BRDF theory. Then, the optimal parameters are solved through the specific algorithm flow for the LED array design. Finally, a flexible LED light source is fabricated with the optimal parameters for different features of the cutting tools and used in the measurement. The measurement results show that the error of the optimized light source is less than 1 \(%\) , and compared with the off-the-shelf light, the measurement accuracy is improved by 9.5$%$ on average. Moreover, this method also presents the potential applied in other complex objects.
Impact of Chocolate percutaneous transluminal angioplasty balloon on vessel preparation in drug-coated balloon angioplasty for femoropopliteal lesion
Authors: Shirai Shigemitsu , Mori Shinsuke , Yamaguchi Kohei , Mizusawa Masafumi , Chishiki Toshiki , Makino Kenji , Honda Yohsuke , Tsutsumi Masakazu , Hiraishi Mana , Kobayashi Norihiro , Yamawaki Masahiro , Ito Yoshiaki
Published: June 2022

Purpose: Compare the impact of Chocolate and conventional balloons on vessel preparation in percutaneous transluminal angioplasty.Materials and Methods:Study included 111 endovascular therapy consecutive cases of femoropopliteal lesions using drug-coated balloon strategy with a 1:1 pre-dilation balloon diameter between February 2020 and August 2021, divided into the Chocolate percutaneous transluminal angioplasty (n=48) and conventional (n=63) groups. Before the availability of Chocolate balloons in Japan (December 2020), a standard semi-compliant or non-compliant balloon was used for vessel preparation. Since its availability, Chocolate percutaneous transluminal angioplasty balloons are used. Primary endpoint was rate of severe dissection after pre-dilatation. Secondary endpoints were angiographic percent diameter stenosis, bailout stent rate, primary patency rate, and freedom from target-lesion-revascularization rate at six months.Results: There was no significant difference in patient and lesion characteristics. Procedural characteristics comprised balloon length 90±37 mm and 149±95 mm (P=0.004) and inflation pressure 11±3 atm and 16±7 atm (P<0.001) in the Chocolate and conventional groups, respectively. Regarding primary endpoint, rates of severe dissection were 4.2% and 25% (P=0.003); regarding secondary endpoints, percent diameter stenosis was 18±15% and 20±17% (P=0.409), and the rate of bailout stenting was 2.1% and 15.9% (P=0.016) in the Chocolate and conventional groups, respectively. Primary patency rates at six months were 89.1% and 85.2% (P=0.670), and freedom from target-lesion-revascularization rate at six months was 100% and 92.8% (P=0.691) in the Chocolate and conventional groups, respectively. Conclusion:Chocolate percutaneous transluminal angioplasty balloons reduce the rate of severe dissection while maintaining sufficient dilatation effect in drug-coated balloon vessel preparation.
Analysis of the risk factors of post-operative seizure in pediatric patients with hydrocephalus undergoing endoscopic third ventriculostomy
Authors: Wang Yubo , Liu Ying , Liu Yutong , Sun Peng , Liu Yang , Du Jianxin , Zeng Gao
Published: June 2022

Objective: The cause and mechanism of epilepsy after endoscopic third ventriculostomy (ETV) have still remained elusive. This single-center study aimed to explore and analyze the risk factors of post-operative seizure in pediatric patients with hydrocephalus undergoing ETV.Methods: Data of pediatric patients with hydrocephalus who were treated with ETV from October 1, 2015, to November 31, 2021, were retrospectively analyzed. Basic demographic characteristics, etiology of hydrocephalus, surgical details, and laboratory measurements were collected. An early postoperative seizure was defined as the occurrence of at least one clinical seizure within 24 h of ETV.Results: A total of 50 participants were included in the study, of whom 5 (10.00%) cases were in postoperative epilepsy group and 45 (90.00%) cases were in non-epilepsy group. Epilepsy patients were younger than those without epilepsy, while no statistically significant difference was found (P = 0.0836). In the age subgroup, children with epilepsy were younger than 2 years old. All patients with epilepsy received Ringer’s solution intraoperatively. The mean postoperative serum calcium and potassium concentrations were significantly lower in patients with epilepsy than in those without epilepsy (Pcalcium=0.0429; Ppotassium= 0.0250). Moreover, a faster decrease of serum potassium and calcium levels was found in children with epilepsy compared with those without epilepsy after ETV.Conclusion: The decrease of serum calcium and potassium levels, younger age, and using Ringer’s solution as irrigation fluid were risk factors for epilepsy after ETV.
Spread Characteristics of Supersonic Noncircular Jets
Authors: Kumar Indradeep , Kumar Manu , Mohanta PK
Published: June 2022

Various research studies on jet spread characteristics have been conducted on the non-circular supersonic jets. However, in these studies, the hydraulic diameter & shape factor of nozzle exit geometry has not been emphasized. The scope of the current investigation includes jet spreading behavior, jet half-width, and axis switching phenomena. This investigation used various types of a nozzle like square, hexagon, elliptical, triangular, circular, and rectangular with divergent and convergent length and throat area ratios are the same. The results ascertained that the hydraulic diameter should be smaller for faster jet mixing. The principal, minor, and diagonal characteristics dimension of hydraulic diameter plays a significant role in spread characteristics. The mixing contribution is lower in circular jets compared to rectangular jets. The distance between the ambient lip and nozzle exit lip plays a vital role at the nozzle exit for mass entertainment.
Tissue paper‑based composite separator using double-crosslinked polymer electrolyte as coating layer for lithium ion battery with superior ion transport and cycle stability
Authors: Hu Yuqin , Zhu Guobin , Zeng Xinyu , Wang Cheng , Xu Jing , Wang Luoxin , Wang Hua
Published: June 2022

Non-woven based battery separators have been developed rapidly in recent years due to their unique advantages in process, cost and performance. In this study, a novel double-crosslinked three-dimensional network coating was constructed by hyperbranched polyethyleneimine (PEI), Polydimethylsiloxane diglycidyl ether (PDMSDGE) and poly(vinylidene fluoride-co-hexafluoropropylene) PVDF-HFP. Then the caoting used to modify tissue paper, which composed of packed cellulose fibers is typical nonwoven with excellent hydrophilic properties required for lithium separators. As we expected, the composite separator shows unique advantages in terms of porosity, electrolyte absorption, mechanical properties and thermal stability. At the same time, the nucleophilic hyperbranched PEI in the coating makes the composite separator in a lithium-rich state in lithium ion battery, so the separator has a certain electric pumping capacity by electrokinetic surface conduction and electroosmosis. As a result, the electrochemical performance and battery performance are excellent too. In addition, we compared the performance of the double-crosslinked coating with two systems of single-crosslinked coating, PEI/PDMSDGE and PEI/PVDF-HFP. The results showed the excellent performance of the composite separator with double-crosslinked coating in terms of mechanical properties retention (95.05%) after electrolyte infiltration and discharge capacity retention (86.89%) after 200 cycles, which given by the stable molecular structure of the three-dimensional double-crosslinked network.
Analysis of high-risk factors for severe Mycoplasma pneumoniae pneumonia associated with plastic bronchitis
Authors: Ma Yuting , Guo Wei , Han Chunjiao , Jin Peng , Wei Diwei , Xu Yongsheng , Zhan Jianghua
Published: June 2022

Background: Plastic bronchitis (PB) is a severe disease with rapid progression and high mortality, and its incidence is increasing. This study created and validated a diagnostic and predictive nomogram based on clinical characteristics to improve the diagnosis of PB in clinical practice.Methods: This randomized, controlled, retrospective, observational study evaluated 447 children with severe Mycoplasma pneumoniae pneumonia, including 147 children with PB (intervention group) and 300 without PB (control group). Independent diagnostic predictors of PB were identified by multivariate logistic regression analysis and area under the receiver operating characteristic curve (AUC≥0.70), and a diagnostic model with six independent clinical characteristics was developed. The performance of the nomogram was assessed using the C-index, calibration curves, and decision curve analysis.Results: Fever duration, neutrophil percentage, lactate dehydrogenase, procalcitonin, interleukin-6, and pleural effusion were independent risk factors for PB and were included in the nomogram. The C-index of the nomogram was 0.900 (95% CI: 0.866–0.934), indicating an excellent ability to discriminate between patients with and without PB. The calibration curve showed good agreement between the predicted and actual probability. The net reclassification improvement(NRI) was 0.1803 (95% CI: 0.0039–0.3567; p=0.0451), and the integrated discrimination improvement(IDI) was 0.1755 (95% CI: 0.1004–0.2505; p<0.001). Decision curve analysis(DCA) showed that the nomogram was clinically useful for detecting PB.Conclusions: We constructed and validated a diagnostic and predictive nomogram with six independent risk factors for PB. The proposed nomogram can improve the early diagnosis of this complication in clinical practice.
Equivalent chassis-based model predictive control for three-axle trucks during tire blowout on expressway
Authors: Fang Chao , Yue Ming , Shangguan Jinyong , Guo Lie
Published: June 2022

Unexpected tire blowout on expressway is one of the most dangerous scenarios for heavy load multi-axle trucks, especially under the inexperienced driver's improper intervention. To this end, this paper proposes an autonomous tire blowout controller for three-axle trucks based on model predictive control (MPC) method. First of all, aiming at balancing the computing load and the path tracking accuracy, an equivalent chassis is transformed based on the stable two-dimensional vehicle dynamic model. Secondly, a tire blowout oriented vehicle high-fidelity dynamic model is established based on the equivalent chassis, in which the vehicle lateral, yaw and roll motion are all considered at the same time. Then, an MPC-based dynamic control strategy is proposed to achieve effective tire blowout suppression with consideration of vehicle rollover stability. Afterwards, a transient vertical tire force shock is employed to simulate the real tire blowout behavior, upon which two typical scenarios are constructed based on the TruckSim/Simulink co-simulation platform. The simulation results illustrate the feasibility and effectiveness of the proposed method.