bluuebunny/crossref_metadata_2025 huggingface dataset:
Therapeutic efficacy of transarterial chemoembolization-radiofrequency ablation combination in hepatocellular carcinoma with a high tumor burden
Authors: FengKui Wang , Yan Zhou , Wei Liu Shuai , Long Hai , Juan Ma , Wanlong Ma , lina Ma , Chun Ding Xiang , xia luo
Published: December 2024

Objective
To evaluate the therapeutic efficacy of the transarterial chemoembolization (TACE)-radiofrequency ablation (RFA) combination in advanced hepatocellular carcinoma (HCC) with a high tumor burden and analyze the clinical factors influencing its efficacy.
Methods
This study performed a retrospective analysis of general data, underlying conditions (hypertension, diabetes, and coronary heart disease), tumor-related indicators (tumor size, number of tumors, tumor distribution, presence of capsule, Chinese Liver Cancer stages, and Barcelona Clinic Liver Cancer stages), clinical laboratory indicators (such as liver and renal function parameters, coagulation parameters, routine blood count, hepatitis B virus DNA presence, and alpha-fetoprotein) affecting postoperative efficacy and 5-year survival outcomes in patients with advanced HCC who underwent TACE-RFA combination treatment from November 2017 to November 2022 at the General Hospital of Ningxia Medical University. The efficacy was evaluated based on modified Response Evaluation Criteria in Solid Tumors. This study included 94 patients (79 males and 15 females) with a mean age of 52.27 ± 10.26 years.
Results
No severe postoperative complications were noted in patients. The median progression-free survival was 14.88 months. The complete response rates at 1, 3, 6, and 12 months were 100%, 90%, 78%, and 57%, respectively. The 1-year, 2-year, 3-year, and 5-year survival rates were 86%, 35%, 11%, and 3%, respectively. Tumor with a diameter of > 5 cm, tumor in the left liver lobe, and aberrant cholinesterase activity decreased the progression-free survival. Prothrombin activity (PTA) was a potential risk factor for prognosis (P < 0.05). Prothrombin time (PT) was a key factor influencing patient survival. Patients with elevated blood urea nitrogen levels exhibited decreased overall survival.
Conclusion
The TACE-RFA combination is effective in improving lesion control and survival rates in patients with large or multiple HCC tumors. Tumor location, serum cholinesterase, PT activity, and blood urea nitrogen are potential predictive indicators for evaluating the prognosis of patients with advanced HCC undergoing TACE-RFA combination treatment.
Insulin Dependence as an Independent Predictor of Complications Following Surgical Treatment of Distal Radius Fracture
Authors: Bramian Allen , Ling Kenny , Butsenko Dmitriy , Komatsu David , Wang Edward
Published: December 2024

Purpose: Diabetes mellitus (DM) is a well-established risk factor for postoperative complications. Distal radius fractures (DRFs) are a common orthopedic injury and often require open reduction and internal fixation (ORIF). The rise of ORIF utilization warrants investigation into factors that may expose patients to postoperative complications following DRF ORIF.
Methods: We queried the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database for cases of DRF ORIF between 2015 and 2021. Cases were stratified into cohorts based on diabetes mellitus (DM) status. The DM cohort was further stratified into non-insulin-dependent DM (NIDDM) and insulin-dependent DM (IDDM) groups. Bivariate logistic regression was conducted to compare patient demographics, comorbidities, and 30-day postoperative complications. Multivariate logistic regressions were conducted to identify associations between diabetes mellitus status and postoperative complications.
Results: A total of 27,761 cases of DRF ORIF were identified from 2015 to 2021. After exclusion criteria were applied, 25,971 cases remained, of which 2,169 (8.4%) cases had DM and 23,802 (91.6%) cases were free of DM. Within the DM cohort, there were 1,392 cases in the NIDDM subgroup and 777 cases in the IDDM subgroup. Relative to the nondiabetic cohort, the IDDM cohort was independently associated with sepsis, septic shock, reintubation, myocardial infarction, blood transfusion, failure to wean off mechanical ventilation, readmission, and nonhome discharge.
Conclusion: The IDDM cohort was independently associated with higher rates of postoperative sepsis, septic shock, reintubation, myocardial infarction, blood transfusion, failure to wean off ventilation, readmission, and nonhome discharge when compared to the nondiabetic cohort following DRF ORIF.
Level of Evidence: Level III; Retrospective Cohort Comparison; Prognosis Study
Prenatal diagnosis of congenital anomalies and birth institution complexity levels in Argentina
Authors: Astudillo Analizia , Groisman Boris , Barbero Pablo , Bidondo María Paz , Liascovich Rosa , Aiello Horacio , Trotta Marianela , Brun Paloma
Published: December 2024

Patients with major congenital anomalies should be delivered in high-complexity institutions, which reduces morbidity and mortality. We aimed to assess the prevalence and prenatal diagnosis rates of selected congenital abnormalities and the complexity levels of birth institutions in a sample of public maternity hospitals in Argentina. Data sources were 1) National Congenital Anomalies Registry, covering the period from 2013 to 2021; and 2) Categorization of birth institutions according to their complexity (high or low). Newborns with the following anomalies were selected for analysis: spina bifida, hydrocephalus, critical congenital heart defects, diaphragmatic hernia, gastroschisis, and omphalocele. Prevalence at birth and prenatal diagnosis rates were calculated according to the birth institution complexity level. A total of 2.214.102 births across 131 institutions were evaluated, with 1.202.311 births in high-complexity institutions and 1.011.791 in low-complexity institutions. The prevalence per 10.000 births and the prenatal diagnosis percentage for the entire sample were: spina bifida 5,40(95%CI 5,10 − 5,71) 68,54%; hydrocephalus 6,96(95% CI 6,62 − 7,32) 78,92%; critical congenital heart defects 11,05(95% CI 10,62 − 11,49) 43,21%; diaphragmatic hernia 3,88(95%CI 3,62 − 4,14) 68,65%; gastroschisis 7,85(95%CI 7,48 − 8,22) 79,27%; omphalocele 2,01(95%CI 1,83 − 2,20) 76,18%. Prevalence and prenatal diagnosis rates were significantly higher in high-complexity institutions. Prenatal diagnosis and perinatal care networks must be improved to ensure that patients with major congenital anomalies are delivered in high-complexity birth institutions. The prevalence and prenatal diagnosis rate, stratified by the complexity level of institutions, can serve as management indicators to evaluate improvements in care quality.
Structure guided functional analysis of the
S. cerevisiae Mre11 complex
Authors: Petrini John , Hohl Marcel , Yu You , Kuryavyi Vitaly , Patel Dinshaw
Published: December 2024

The Mre11 complex comprises Mre11, Rad50 and Nbs1 (Xrs2 in S. cerevisiae). The core components, Mre11 and Rad50 are highly conserved, with readily identifiable orthologs in all clades of life, whereas Nbs1/Xrs2 are present only in eukaryotes. In eukaryotes, the complex is integral to the DNA damage response, acting in DNA double strand break (DSB) detection and repair, and the activation of DNA damage signaling. We present here a 3.2 Å cryo-EM structure of the S. cerevisiae Mre11-Rad50 complex with bound dsDNA. The structure provided a foundation for detailed mutational analyses regarding homo and heterotypic protein interfaces, as well as DNA binding properties of Rad50. We define several conserved residues in Rad50 and Mre11 that are critical to complex assembly as well as for DNA binding. In addition, the data reveal that the Rad50 coiled coil domain influences ATP hydrolysis over long distances.
The Long-Term Impact of Single Intraoperative Instillation of Pirarubicin after Radical Nephroureterectomy on Local and Systemic Cancer Control: A Prospective, Multicenter, Randomized Trial
Authors: Suzuki Toru , Kanematsu Akihiro , Tanaka Shiro , Kanamaru Sojun , Yamasaki Toshinari , Kawakita Mutsushi , Yamamoto Shingo
Published: December 2024

Purpose: Although the preventive effect against intravesical recurrence (IVR) has been established for single instillation of chemotherapy during or after radical surgery of upper urinary tract urothelial carcinoma (UTUC), there has been no research on the long-term outcome. This study aims to investigate the IVR and long-term survival outcome of a single intraoperative instillation of pirarubicin during radical nephroureterectomy (RNU).
Methods: In this prospective, multicenter, randomized trial, 97 patients undergoing RNU between August 2012 and January 2019 were randomly assigned either to receive a single intraoperative pirarubicin instillation or to serve as the controls.
Results: A total of 80 patients were analyzed, including 42 in the pirarubicin group and 38 in the control group. The median follow-up period was 58.5 months and 62 months in the pirarubicin and the control groups, respectively. In patients who did not experience IVR, the median follow-up period was 59 months and 61 months in the pirarubicin and the control groups, respectively. There was no significant difference in OS between the two groups, although the IVR rate was significantly lower in pirarubicin group (p = 0.044). Multivariable analyses revealed that the pirarubicin instillation was the only independent factor for IVR.
Conclusions: The present trial demonstrated that a single intraoperative instillation of pirarubicin resulted in a significant and long-term reduction of IVR, although there was no significant difference in OS.
Use of a portable anthropometer to assess body weight, body movement, and crying frequency in newborns: An observational study
Authors: Suzuki Tomoo , Saito Kotoko , Ono Masanori , Nishibukuro Maria , Nara Shonosuke , Suganami Yusuke , Yamanaka Gaku , Oshima Kumi , Yachi Kaoru , Nemoto Tetsu , Sakai Yosuke , Kojima Junya , Kuji Naoaki , Nishi Hirotaka , Shimada Keiko
Published: December 2024

Background
Developmental support for newborns is a global public health concern. Neonatal body movements serve as key indicators of overall health, playing a pivotal role in neurodevelopment. Conventional methods of assessing newborn body movements are subjective, with limited accuracy and reliability. In this study we investigated the correlation between body weight and movements using an originally developed, portable, and battery-powered device. We also explored the relationship between the frequency of newborn cries and their body weight.
Methods
This observational study enrolled newborns collected from two university hospitals from August 2022 to November 2023. Movement was measured using a body movement measuring device equipped with piezoelectric sensors, a foot switch, and acceleration inputs. Body movements were represented as piezoelectric peaks. Correlation and regression analyses explored the relationships among neonatal body weight (at the time of the study), body movement, crying frequency, and crying duration.
Results
A positive correlation was identified between body weight and number of body movements (R2 = 0.2884). The regression analysis revealed a linear relationship between body weight and body movements per minute, and body weight and the number of cries per hour. Crying time also increased with increasing body weight (R2 = 0.5079).
Conclusions
Overall, these results indicate that the body movement measuring system allowed the non-invasive detection of neonatal body movements, establishing a robust positive correlation between body weight and the number of body movements. This method may offer an accurate and objective means to assess newborn body movements and crying frequency to identify at-risk infants who require early intervention.
Impact of supplementing Lactobacillus fermentum MN–LF23 on the eradication of Helicobacter pylori with 14–day standard quadruple therapy: A randomized, double–blind, placebo–controlled trial
Authors: Zhao Yuyang , Niu Xiaokang , Zhang Yong , Zhao Liang , Zhang Liwei , He Jingjing , Zhang Qi , Mao Yuejian , Wang Fuqing , Zhao Xiaohui , Wang Ran
Published: December 2024

Background: The effect of probiotics onHelicobacter pylori (Hp) infection demonstrates considerable heterogeneity. This study aims to elucidate the role of Lactobacillus fermentum MN–LF23 (MN–LF23) in Hp–infected populations.
Methods: A total of 94 adult patients with confirmed Hp infection were enrolled in this study and randomly allocated to the placebo or MN–LF23 group. Patients initially received either placebo or probiotics along with standard quadruple therapy for 2 weeks, followed by continued administration of either placebo or probiotics for an additional 4 weeks. The eradication of Hp, serum levels of inflammatory factors, and alterations in gastrointestinal symptoms were assessed at weeks 0, 2, and 6, while fecal samples were collected for metagenomic sequencing.
Results: The results showed no significant difference (P = 1) in the eradication rate between the placebo group (85.11%) and the probiotic group (82.98%). Following treatment, the incidence of constipation, dyspepsia, and Gastrointestinal Symptom Rating Scale (GSRS) scores in the probiotic group were markedly lower (P < 0.05) compared to those observed in the placebo group. Throughout the treatment process, there were no significant differences in TNF–α and IL–1β levels between the two groups. Compared to the placebo group, the probiotic group exhibited a significant increase in beneficial bacteria such as Lactobacillus fermentum, Lactobacillus plantarum, Bifidobacterium longum, Coprococcus caltus, and Clostridium butyricum.
Conclusion: MN–LF23 supplementation did not improve the eradication rate of standard quadruple therapy. However, it significantly reduced the overall GSRS score, improved digestive and constipation symptoms, and promoted the proliferation of beneficial bacteria in the intestine.
Identification of Two Biological Subgroups of Complex Regional Pain Syndrome Type 1 by Transcriptomic Profiling of Skin and Blood
Authors: Valdés Melina Pérez Vertti , Jüngel Astrid , Bitterli Pamela , Devan Jan , Rehrauer Hubert , Opitz Lennart , Sirucek Laura , Schweinhardt Petra , Catanzaro Sabrina , Distler Oliver , Brunner Florian , Dudli Stefan
Published: December 2024

Background
Patients with Complex Regional Pain Syndrome (CRPS) present prolonged, debilitating pain and functional impairment. Treatments are not disease-modifying due to the poorly understood underlying pathomechanisms. This study aimed to identify the molecular signatures of potential CRPS type 1 subgroups.
Methods
Twelve women with CRPS type 1 were included. Demographics and pain questionnaires were recorded. Skin biopsies of the affected and non-affected limbs (n = 6 + 6) and peripheral blood (n = 11) were collected. RNA sequencing was performed on skin and peripheral blood mononuclear cells (PBMCs). Twenty cytokines were quantified in blood plasma (n = 12).
Results
Cluster analysis of the affected skin identified two CRPS subgroups (SG). SG1 exhibited increased gene expression related to epidermal development, metabolic processes, and a greater abundance of keratinocytes. SG2 showed enhanced transcriptomic changes in inflammatory, immune, and fibrotic processes, along with higher abundance of fibroblasts, macrophages, and endothelial cells. PBMCs transcriptomics revealed the same SG1/SG2 clusters and highlighted a stronger inflammatory response in the blood of SG1, suggesting distinct tissue-specific immune responses for the subgroups. Interleukin-1 receptor antagonist (IL-1RA) levels were higher in the blood plasma of SG1 (FDR = 0.01), consistent with its encoding gene IL1RN expression in PBMCs (log2 FC = 1.10, P < 0.001) and affected skin (log2 FC = 0.88, P = 0.006). Subgroups did not differ in demographic or clinical parameters but correlations among clinical factors varied between them.
Conclusions
This study identified two biological subgroups of CRPS type 1 through skin and blood transcriptomic profiling, advancing the understanding of this condition. This could facilitate the development of targeted treatments for CRPS type 1.
Determination of the Relationship between Hyperemesis Gravidarum and Systemic Inflammation Markers: A Case-Control Study
Authors: Adıgüzel Fikriye Işıl , Altınkaya Serhat , Kükrer Sadık , Nessar Ahmet Zeki , Uysal Gülsüm , Adıgüzel Cevdet
Published: December 2024

Background
We planned our study to investigate the relationship between HEG and inflammation markers like NLR, PLR and MLR.
Materials ant method:
A total of 150 pregnant women diagnosed with HEG and 150 controls were included in our study. Data were analyzed for demographic variables, complete blood count results, and urinary ketonuria levels.
Results
We found NLR, PLR and MLR to be significantly higher in HEG patients than controls (p < 0.05), indicating a potential role of systemic inflammation in HEG pathophysiology. ROC analysis revealed moderate discrimination powers for these markers, suggesting their utility as adjunctive diagnostic tools in clinical settings. However, no correlation was found between inflammatory markers and the severity of ketonuria.
Conclusions
NLR, PLR and MLR values ​​can be used as indicator for HEG as a result of the inflammatory process in HEG group.
Metabolism of Cannabidiol in Respiratory Associated Cells and HepG2- derived cells and Molecular Docking of Cannabidiol and its Metabolites with CYP Enzymes and Cannabinoid-2 Receptor
Authors: Tongkanarak Krittawan , Paul Pijush Kumar , Bintang Muhammad A. Khumaini Mudhar , Suedee Roongnapa , Sawatdee Somchai , Srich Teerapol
Published: December 2024

Cannabidiol (CBD) has been reported in medical applications for various indications. The enzymatic metabolism of CBD is not fully understood in the different routes of administration. This research aimed to identify the CBD metabolites after incubation of CBD with derived hepatocyte cells (HepG2), bronchial epithelial cells (NCI-H358), alveolar cells (A549), and alveolar macrophage cells (NR8383). The LC-MS/MS method was developed to quantify the CBD and its metabolites. Molecular docking was employed to evaluate the binding affinity of CBD with different cytochrome P-450 (CYP) enzymes and further predict the implication of drug-drug interactions. CBD and major metabolites of CBD were also docked with CB2 receptors. The results revealed that only HepG2 cells metabolized CBD to 7-hydroxy-CBD (7-OH-CBD) and 7-carboxy-CBD (7-COOH-CBD), whereas other respiratory cell lines and alveolar macrophages were found to have mainly CBD in the incubated samples without any major metabolites. The CYP2C19 and CYP3A4 enzymes were responsible for CBD conversion to hydroxylated CBD metabolites. The 7-OH-CBD and 7-COOH-CBD metabolites were found to bind to CB2 receptors with different affinities. The relative abundance of CBD and major metabolites may indicate the potential route of CBD administration.
Greater effort, greater pain: Givers’ feelings of social exclusion in gift failures across close and distant relationships
Authors: Lyu Dong , Wang Zhongfeng , Song Rongrong , Jin Jia
Published: December 2024

In gift-giving, it violates social norms for recipients to explicitly deliver negative evaluations of gifts, potentially causing emotional or psychological harm to givers, which raises ethical concerns. However, recent research indicates that this behavior is surprisingly common among young adults. While substantial research has focused on instances where recipients are dissatisfied with gifts, little attention has been given to the unique emotional harm experienced by givers and the underlying psychological processes involved. This study addresses this gap from the perspective of social exclusion and examines how givers’ feelings of social exclusion differ between close and distant relationships. We argue that givers tend to devote more effort to selecting gifts for close (vs. distant) recipients, leading them to hold higher expectations of gifting success in close relationships. Instead, when givers get negative feedback from close recipients, they perceive a higher level of expectancy violation, which, in turn, backfires on their perceived threats to the relationship and arouses stronger feelings of social exclusion than in distant relationships. Results from three experiments substantiate our theoretical claims based on the expectancy-violation theory. Further, we apply neuroscience technology (event-related potentials, ERPs) to capture the cognitive characteristics of givers’ emotional experiences, offering additional evidence and insights into givers’ feelings of social exclusion. This research contributes to a deeper understanding of the emotional harm givers experience when their gifts are unappreciated, highlighting the ethical aspect of gift-giving.
The Association between Social Media Use and Age, Sex, Self-esteem and Self-consciousness in University Students
Authors: Adams Sherifdeen , Alhassan Salisu
Published: December 2024

Introduction:
Over the last decade, social media usage has become a progressively common leisure activity. Even though social media use is not problematic to most people, some users seem to be involved in it addictively and/or compulsively.
Aims
The study sought to examine the association between social media use and age, sex, self-esteem and self-consciousness in university students.
Methods
The study adopted a correlational design. Forty-six (N = 46) students of different nationalities in the United Kingdom university population completed the Bergen Social Media Addiction Scale (BSMAS), Rosenberg Self-Esteem Scale (RSES) and Self-consciousness Scale-Revised (SCSR) through an online questionnaire. Data were analyzed using SPSS, with results presented through frequencies, percentages, mean, standard deviation and multiply regression model. Statistical significance was set at 0.05, with 95% confidence intervals assessed.
Results
The study found that variables such as Self-Esteem (p < .02) and Self-Consciousness (p < .01) had a significant association with Social Media Use. The other covariates were not statistically significant.
Conclusion
Spending a lot of time on social media can impact university students’ self-esteem and self-consciousness.
Precise modulation of electron spin states in metal-organic framework towards exceptional oxygen evolution reaction
Authors: Huang Minghua , Hou Xianbiao , Ni Tengjia , Zhang Zhaozheng , Zhou Jian , Zhang Shucong , Dai Shuixing , Chu Lei , Wang Huanlei , Huang Bolong
Published: December 2024

Spin configuration and coordination environment changes have emerged as promising strategies to boost the oxygen evolution reaction (OER) activity. However, achieving the precise and gradual regulation of both spin states and coordination environment to elucidate the structure-activity relationship remains a key priority and is rarely reported. In this work, we successfully induce the gradual transition of spin states of Fe sites from low spin state to a medium spin state and ultimately to high spin state by meticulously adjusting coordination environment within NiFe-MOF, while the Ni sites still keep a low spin state. Experimental and theoretical calculations confirm the precise regulation of spin polarization and electrons migration from the Fe-t2g to the Fe-eg orbitals with a reduced coordination saturation, which optimizes the spin orbital exchange interactions between Fe and Ni ions and facilitates adsorption of reaction intermediates. The NiFe-MOF-D3 with unique NiO6-FeO4 geometric structure exhibits low overpotential of 328 mV@1 A cm-2 and 365 mV@1.5 A cm-2 in alkaline medium. Furthermore, the assembled alkaline electrolyzer also presents remarkable activity (1.77 V@500 mA cm-2) and lower cost ($ 0.94) than the target of U.S. Department of Energy ($ 2.00).
The First Non-Pyrophoric Precursor for the Low Temperature Deposition of Metallic Aluminium
Authors: Knapp Caroline , de Faria Erica Neves , Douglas Samuel , Mrig Shreya , Santoni Leonardo , Clancy Adam , Wilson Daniel
Published: December 2024

The development of microelectronics prompts a search for precursors that can deposit conductive features. There is scarce research focusing on Al as it is normally deposited using pyrophoric and highly air- and moisture-sensitive AlH3 etherates or aminates. By careful consideration, ligands can impart increased stability while maintaining the ability to deposit the target materials. To this end, we have engineered an aluminium complex that can undergo reductant-free conversion to Al(0) at 100°C. Our strategy utilized multi-step synthetic design featuring β‑ketoiminate (acnac) bidentate ligands, [Al(R-acnac)2Cl] (R = Me, Et, iPr, Ph and Mes, 1-5) that were used as starting materials to obtain aluminium hydride complexes: the polymeric amidoalane Li[AlH2(iPr‑Hacnac)AlH3]n (6) and the imidoalane cluster [AlH2AlH2(N‑Mes)3(AlH2 ּ Li(Et2O)2)2] (8). When heated under vacuum at 100°C, 8 decomposes into aluminium metal, confirmed by XRD, TEM, XPS. This represents the first instance of a route to metallic aluminium involving non-pyrophoric precursors at low temperature.
Pathogenetic significance of IL-6 in children with vitamin D deficiency in COVID-19
Authors: Huseynova Ilhama , Qazanfar Hasanov Alakbar , Makhmud Mammadova Fakhriya , Adil Gafarov Ismayil
Published: December 2024

Scientific studies on the relationship between vitamin D levels and inflammatory markers in children are scarce today. The aim of this study is to compare the relationship of vitamin D level with inflammatory marker - IL-6 in children with COVID-19 (PCR positive) and its role in the clinical development of the disease. The examination included 90 children aged 1 to 17 years. The test for SARS-CoV-2 virus RNA was positive in the pathological material from the nasopharynx in 75 patients. The control group consisted of 15 healthy children. Examination methods included anamnestic, clinical, instrumental and laboratory studies. During the study, the level of vitamin D was assessed according to two parameters: the degree of vitamin D and the diagnosis of COVID-19. In both groups, the level of the inflammatory marker IL-6 was assessed. As a result, COVID-19 disease in children, as well as vitamin D levels were considered as factors that play an important role in the change of IL-6 level.
Proteomic profiling of the serological response to a chemically-inactivated nodavirus vaccine in European sea bass Dicentrarchus labrax
Authors: Chérif Nadia , Ghedira Kais , Agrebi Houda , Najahi Semah , Mejri Hiba , Azouz Saifeddine , Kielbasa Mélodie , Armengaud Jean , Kangethe Richard Thiga , Wijewardana Viskam , Bouhaouala-Zahar Balkiss , Sghaier Haitham
Published: December 2024

Analysing animal responses to immunization is pivotal in vaccine development by evaluating immune response, assessing vaccine safety and efficacy, and providing crucial insights into immune protection mechanisms. These insights are indispensable for advancing vaccines through trial stages and regulatory approval processes, as well as deciphering the molecular signatures of approved vaccines, which not only enhances our understanding of existing vaccines but also informs the rational design of new ones. This study aims to elucidate alterations in protein abundance patterns in the sera of European sea bass, Dicentrarchus labrax, following immunization with a chemically-inactivated nodavirus vaccine. The shotgun proteome comparison revealed that in vaccinated animals, compared to controls, there is a modulation of the redox balance favouring reactive oxygen species, an intricate interplay between coagulation and the immune system resulting in the under-abundance of hematopoiesis-related FLT3, and indications of functional adaptive immunity demonstrated by the under-abundance of pentraxin fusion protein-like and the over-abundance of myosins. To the best of our knowledge, this study represents the inaugural investigation of the immune response in fish using a proteomics approach, employing D. labrax as the host and nodavirus as the pathogen used for vaccination and challenge.
Space-based Reflectors for Night-time Illumination and Enhancing Solar Power Generation over India
Authors: Sakuru Sai Krishna V. S. , Ramana M. V.
Published: December 2024

Climate change agreements to contain global warming caused by greenhouse gas (GHG) emissions from fossil fuel-based sources necessitate a shift to renewables for energy generation. India's growing population drives her energy consumption and is predicted to peak by 2060. However, India’s per capita consumption of primary energy (7,129 kWh/yr in 2022) and electricity (1,311 kWh/yr) is much lower than for developed countries. Parity in per capita consumption by 2060 implies an increase in primary energy consumption by 56,277 TWh and the installed capacity for power generation by 2,482 GW from 2022 levels, and requires innovative carbon-neutral/low-carbon solutions. Sunlight reflected from space-based orbiting satellite reflectors (OSRs) can provide night-time illumination and enhance power generation from Solar Power Parks (SPPs) during dawn/dusk when natural sunlight is minimal. A constellation of 9 (34) pairs of OSRs with a mirror diameter of 1 km can provide continuous illumination ≥ 2 lux (≥ 8 lux) over New Delhi and illuminate other significant cities. OSRs in sun-synchronous dawn/dusk orbit at 1000 km altitude can increase power generation from SPPs by about 72.8 kWh/km2 during overhead passes. Our results indicate the potential for OSRs to meet future energy demand and reduce GHG emissions from the power sector.
The Nexus of Video Gaming Experiences: The Associations Among Basic Needs in Games, Real-Life Basic Needs, Well-Being Indicators, and Problematic Online Gaming
Authors: Subasi Mustafa , Gürkan Emre , Karaman Hakan , Bulut Sefa , Osin Evgeny N.
Published: December 2024

Recent research highlights the vital roles of basic needs in video gaming experiences. Both need-supportive and need-frustrating video gaming experiences have theoretical and practical implications for real-life need satisfaction and frustration, and well-being outcomes. This study aimed to adapt the Basic Needs in Games Scale (BANGS) into Turkish, tested the psychometric properties of “gaming in general” and “gaming in a particular game” versions of the Turkish BANGS, and investigated the associations among the BANGS, problematic online gaming, life satisfaction, meaning in life (i.e., coherence, purpose, significance), and real-life basic psychological needs. This study recruited a sample of 247 Turkish-speaking participants who played at least a video game over the past two weeks. The results provided evidence for the structural validity of the Turkish BANGS versions, and demonstrated good reliability for the BANGS subscales. The findings indicated that indicators of need satisfaction and frustration in games were primarily associated with their real-life counterparts, and showed complex associations with life satisfaction, meaning in life, and problematic online gaming. The implications for further research on basic needs in video games are discussed.
Digitales Kollaborationslernen lebendig und nachhaltig gestalten
Authors: Schön Michael , Arnold Rolf
Published: December 2024

In diesem Beitrag wird ein asynchrones Onlineseminarkonzept aus der universitären Lehrkräftebildung vorgestellt, das selbstgesteuertes und nachhaltiges Lernen ermöglicht. Inhaltlich steht die Vermittlung von lehramtsspezifischen Grundlagen zur schulischen Inklusion im Fokus. Darüber hinaus liegt der allgemeine Schwerpunkt der Konzeption inhaltsunabhängig auf der Förderung der Kooperations- und Kollaborationsfähigkeit, den Feedback- und Selbstlernkompetenzen sowie der Fähigkeit zum Perspektivenwechsel bei den teilnehmenden Studierenden. Das digitale Lernangebot wurde mithilfe des Learning-Management-Systems OLAT nach Prinzipien des lebendigen und nachhaltigen Lernens gestaltet und enthält mit einem Punktekonzept Elemente der Gamification. Es ist selbstgesteuert, produktiv, aktivierend, situationsbezogen und fördert die soziale Interaktion, um gemeinsames Lernen zu unterstützen. Seminarevaluationen und offene Befragungen der Teilnehmenden über mehrere Semester hinweg zeigen, dass das Konzept sehr gut aufgenommen wird und nach subjektivem Empfinden die genannten Ziele erfüllen kann.
Wolf von Kalckreuth, 1887–1906
Authors: Heyer Theresa
Published: December 2024

Wolf von Kalckreuth übertrug vor seinem frühen Tod große Teile des Werks von Baudelaire und Verlaine. Er trug damit erheblich zu deren Bekanntwerden im deutschsprachigen Raum bei. Seine Übersetzungen werden bis heute in Anthologien nachgedruckt.
Rolf-Dietrich Keil, 1923–2018
Authors: Göbler Frank
Published: December 2024

Rolf-Dietrich Keil wurde vor allem als Puškin-Übersetzer sowie als Initiator und langjähriger Vorsitzender der Deutschen Puschkin-Gesellschaft bekannt. Sein vielfältiges Œuvre umfasst aber nicht nur zahlreiche Übersetzungen, unter denen dichterische Übertragungen von Verstexten eine prominente Stellung einnehmen, sondern auch sprachwissenschaftliche, didaktische und literaturwissenschaftliche Artikel und Monographien sowie Erinnerungen und eigene Dichtungen.
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Authors: Mawlood Hafssat Najm
Published: December 2024

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Corruption and Iraq Banks Performance: Expanding the “Grease or Sand the Wheel” Hypothesis
Authors: Altaee Hatem Hatef Abdulkadhim , Alsalim Munadhil Abduljabar , Ghani Naz Hiwa
Published: December 2024

The main goal of the study is to investigate the effect of corruption on the profitability of Iraqi banks during the period 2012–2020. The paper used a sample of nine private banks that account for a considerable proportion of the overall assets of the Iraqi commercial banks. The advanced technique of method of moment quantile regression (MMQREG) is used. To validate the initial results, we use the feasible generalized least squares (FGLS) and panel-corrected standard errors (PCSEs) techniques. Our results support the ‘grease or sand the wheel’ hypothesis of corruption for Iraqi banks. This finding supports the view that the current weak governance structures and the power-sharing political system in the country serve as an ‘escape hatch’ for individuals in power. Furthermore, the findings of the PCSE and FGLS validated the MMQREG results in terms of coefficient sign. Correspondingly, income and inflation are shown to be positive drivers of ROAA. Furthermore, it was demonstrated that Iraqi banks are not getting any benefit from economies of scale regarding financial performance. On the other hand, our results reveal that the ratio of cost income has a statistically significant negative effect on bank profitability, implying that Iraqi private banks are operating below their optimal capacity.
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Authors: Kareem Gazang khalid
Published: December 2024

یهدف البحث إلى التعرف على السياسات الحديثة للاقتصاد الكلي (النقدية والمالية) دورها في النمو الاقتصادي في العراق مقارنة بالإمارات ومصر ، وايضاً هدف إلى تحليل مدى فعالية كل من السياسات النقدية و المالية في التأثير على النمو الاقتصادي متمثلاً بنسبة التغير في النمو في الناتج المحلي الاجمالي. للسياسة المالية: (الإنفاق العام، والإيرادات العامة)، وجانبين للسياسة النقدية: (سعر الصرف ، سعر الفائدة وحجم الائتمان المحلي الممنوح للقطاع الخاص). لبيانات خلال المدة( 2000-2021 ) . واظهرت نتائج الدراسة وجود علاقة وتأثير واضح في الاجل الطويل وبمستوى عالي بين التغيرات المستقلة لكل من السياسة النقدية والمالية والمتغير التابع في النمو الاقتصادي ، وهذا يعني ان كل من السياستين المالية والنقدية يساهمان في التأثير على النمو الاقتصادي كما بينت نتائج الدراسة ، ان فعالية السياسة المالية والمتمثلة في الانفاق الحكومي كانت اكثر فعالية في التأثير على النمو الاقتصادي من تأثير السياسة النقدية . وقدم االبحث عدد من المقترحات الهامة لتحقيق الاستقرار الاقتصادي.
Geomorphology of Gali Ali Beg Valley Area in Erbil Governorate
Authors: Alhusainy Hikmat Abdulazeez Hamad
Published: December 2024

Due to the importance of the study area for Erbil governorate and for it is practical and strategic implications, as it represents the only pass way that passes a high and complex structural ranges that linked the north part of the governorate with middle and south parts, and also for it is tourism importance and scientific value for the geologic purposes in particular, as it reveals rock formations at great depths in the valley area and for the lack of paying attention to this area from scientific point of view due to scarcity of geological and geomorphological studies about it, so the study aimed to study the landforms, perhaps its data and analyses contribute to development plans and projects that may include the study area in the future, as well as developing solutions for the geomorphological hazards taking places in the study area such as mass movements which are threatening architectures foundations, facilities and also people there. The main objectives of this study are to simplify and clarify the complex view about the area for the researchers and those interested in the field of geomorphology and other related disciplines, though the study found out the valley area is highly affected by its structural status. That represented by many folds which are subjected to main and giant faults; therefore, the structural factor was the dominants agents in developing most of the landforms in the area such steep slopes and landforms caused by mass movements, waterfalls, springs and the gorges …. etc., and also there is some geomorphic hazards in which some solutions have been proposed for.
Technological Vigilance and its Impact on Improving the Dimensions of Health Service Quality an Analytical Study of the Opinions of Functional and Medical Staff at Azadi Hospital in Dohuk and Gulan Hospital in Akre
Authors: Shamsadden Faris Younus , Zeebaree Mohammed Rasheed Yaseen
Published: December 2024

Abstract
This study aims to evaluate the level of technological vigilance in relation to health service quality at Azadi Hospital in Dohuk and Gulan Hospital in Akre. The study also aims to determine how technological vigilance and its dimensions (market vigilance, information vigilance, and competitive vigilance) affect the health service quality in these hospitals. The importance of this research lies in providing a theoretical and practical framework that explains the relationship between technological vigilance and health service quality.
 
The study used a descriptive-analytical approach and relied on questionnaires to collect data. The randomly selected staff members from Azadi and Gulan Hospitals have participated in the survey. A total of 40 questionnaires were distributed to supportive and medical staff at Azadi Hospital, and 34 questionnaires were distributed to supportive and medical staff at Gulan Hospital. A total of 62 questionnaires were returned from both hospitals .In general, the research attempts to answer the following questions:
1-What is the nature and type of correlations between dimensions of technological vigilance and the health service quality among supportive and medical staff at Azadi and Gulan Hospitals?
  2- What is the nature and type of influence relationships between dimensions of technological vigilance and the health service quality among supportive and medical staff at Azadi and Gulan Hospitals?
The research aims to the following:

Describe and diagnose the levels of dimensions of technological vigilance and health service quality among supportive and medical staff at both hospitals.
Test the correlation between dimensions of technological vigilance and the health service quality among supportive and medical staff at both hospitals.
To investigate the impact of dimensions of technological vigilance and the quality of health services among supportive and medical staff at both hospitals.The researchers employed various statistical tools to analyze and test research hypotheses for the data collected through questionnaires from supportive staff (administrators, engineers, and accountants) and medical staff (doctors and nurses) in the two investigated hospitals. The research drew several conclusions, with the most important one confirming a significant and positive correlation between technological vigilance and its dimensions, and health service quality. The study also found a significant and positive effect between these two variables. The study also showed that the competitive vigilance dimension had the highest significant and positive correlation and effect on health service quality, followed by informational technological vigilance and market technological vigilance, respectively. Based on the findings, various suggestions have been put forward.
Uncertainty quantification and global sensitivity analysis of turbulence model closure coefficients for sheet cavity flow around a hydrofoil
Authors:   Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy, Romani Simone , Morgut Mitja ,   Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy, Parussini Lucia , Piller Marzio ,   Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy,   Department of Engineering and Architecture, University of Trieste, 34127 Trieste, Italy
Published: December 2024

This paper presents the uncertainty quantification and sensitivity analysis of the standard k-ɛ turbulence model applied to the numerical prediction of the non-cavitating and cavitating flow around a 2D NACA66MOD hydrofoil. The turbulence model parameters are treated as epistemic uncertain variables, and the forward propagation of uncertainty is evaluated using the non-intrusive polynomial chaos approach. The required simulations are performed using a commercial CFD solver. The Sobol indices are used to rank the relative contribution of closure coefficients to the total uncertainty in the output quantities. For the considered case, the ranking of the model parameters is not influenced by the presence of the sheet cavity flow, while it varies with respect to the considered output quantity.
1T-MoS2: UMA BREVE REVISÃO DAS PROPRIEDADES E APLICAÇÕES DESTE POLIMORFO METÁLICO DO DISSULFETO DE MOLIBDÊNIO
Authors: Moreira Pinto Felipe , de Almeida La Porta Felipe , Wypych Fernando
Published: December 2024

1T-MoS2: A BRIEF REVIEW OF THE PROPERTIES AND APPLICATIONS OF THIS METALLIC POLYMORPH OF THE MOLYBDENUM DISULDIFE. Due to its excellent physicochemical properties, molybdenum disulfide (MoS2) has emerged as one of the most promising two-dimensional materials, comparable to graphene. This material can occur in three polymorphic/polytypic structures (1T, 2H and 3R) but this article will only focus on the polymorph 1T-MoS2 and its distorted variants 1T’, 1T” and T”’. Thus, our objective is to summarize recent advances in understanding the properties of this metallic polytype. Due to their sui generis structures, anisotropic properties, and possibilities of being delaminated and exfoliated and their layers manipulated and reassembled in the most diverse ways, they offer a world of opportunities for future applications, it is enough to have a fertile imagination for important contributions to emerge, even in research centers that have instrumental limitations and specialized personnel.
Integrated management of lakes, reservoirs, and their basins is critical for a climate-resilient planet: an urgent wake-up call from collective amnesia
Authors: Hirji Rafik F. , Duda Alfred
Published: December 2024

Integrated management of lakes and reservoirs and their basins is vital for preserving their significant socioeconomic and ecological benefits, which are essential for climate resilience. Lakes and reservoirs store 88% of the Earth's fresh surface water, providing water, food, energy security, flood protection, drought mitigation, and ecosystem services. This article highlights the rapid depletion and deterioration of these Lentic (standing) waters and the consequent loss of valuable benefits, threatening the global water supply and exacerbating environmental and climate crises. It discusses the evolution of lake management practices and contrasts these with strategies for managing lotic (flowing) waters. It summarizes collaborative best practices for Lake Basin Governance developed through a multiagency partnership. It reviews recent global initiatives to sustainably manage lakes, integrate storage, address aging dams, and foster partnerships and cooperation. It highlights the widespread failures across international water and environmental policies and institutions. The article calls on the global water and environmental community to awaken from collective amnesia, act, and implement best practices for governing lakes, reservoirs, and basins. Our companion article examines the institutional inertia hindering integrated action and offers collaborative opportunities for integrating land and water management in lake and reservoir basins to enhance climate resilience.
Optimising Venturi flume oxygen transfer efficiency using uncertainty-aware decision trees
Authors: Tiwari Nand Kumar , Panwar Dinesh
Published: December 2024

This study optimizes standard oxygen transfer efficiency (SOTE) in Venturi flumes investigating the impact of key parameters such as discharge per unit width (q), throat width (W), throat length (F), upstream entrance width (E), and gauge readings (Ha and Hb). To achieve this, a comprehensive experimental dataset was analyzed using multiple linear regression (MLR), multiple nonlinear regression (MNLR), gradient boosting machine (GBM), extreme gradient boosting (XRT), random forest (RF), M5 (pruned and unpruned), random tree (RT), and reduced error pruning (REP). Model performance was evaluated based on key metrics: correlation coefficient (CC), root mean square error (RMSE), and mean absolute error (MAE). Among the proposed models, M5_Unprun emerged as the top performer, exhibiting the highest CC (0.9455), the lowest RMSE (0.1918), and the lowest MAE (0.0030). GBM followed closely with a CC value of 0.9372, an RMSE value of 0.2067, and an MAE value of 0.0006. Uncertainty analysis further solidified the superior performance of M5_Unpruned (0.7522) and GBM (0.8055), with narrower prediction bands compared to other models, including MLR, which exhibited the widest band (1.4320). One-way analysis of variance confirmed the reliability and robustness of the proposed models. Sensitivity, correlation, and SHapley Additive exPlanations analyses identified W and Hb as the most influencing factors.
POEMAS - CONCEIÇÃO EVARISTO
Authors: Lima Duarte Constância
Published: December 2024

Doutora em Literatura Comparada pela Universidade Federal Fluminense. É poetisa, romancista e ensaísta. Vencedora do Prêmio Jabuti de 2015 (uma das mais importantes honrarias concedidas a escritoras(es) brasileiras(os) e autora, entre outros, de Becos da memória (romance, 2006) e Canção para ninar menino grande (novela, 2017).
ENTREVISTA COM DUEN NEKA'HEN BAZÁN SACCHI
Authors: Expósito Julia , Sacchi Emiliano
Published: December 2024

ENTREVISTA