bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Based Foodborne Pathogen Detection Techniques; A Bibliometric Computational Analysis
Authors: Utami Riski Gusri , Anni Faridah  , Rahmi Holinesti  , Vici Syahril Chairani  , Sari Mustika  , Ahadul Putra  , Fitri Yasih
Published: October 2024

Recent advances in molecular-based food pathogen detection technology and the increased complexity of the food supply chain make it critical to comprehend current trends and possibilities. This bibliometric study examined molecular-based detection approaches for foodborne pathogens during the past 15 years, including nation contribution, keyword trends, relevant journals, citations, and cutting-edge technology. Scopus returned 2114 documents. Vosviewer and R-Biblioshiny visualized the research. The annual number of publications fluctuated upward. The International Journal of Food Microbiology published the most, but the Journal of Biosensors and Bioelectronics had the most significant impact. The most cited articles described high-sensitivity foodborne pathogen detection methods such as PCR, multiplex PCR, real-time PCR, NASBA, LAMP, and FRET biosensors. China and the USA led the research publications, citations, and collaborations. The co-occurrence analysis of keywords indicates that “Real-time PCR,” Isolation and Purification, “Genetics,” “Biosensing Techniques,” “RNA extraction,” “Nucleic Acid Amplification,” and “Rapid detection” were the main research priorities regarding the topic of food-pathogen detection. Meanwhile, “CRISPR/Cas12”, “CRISPR-Associated Proteins,” “LAMP assay,” and Biosensing Techniques have trended in the past five years. These technologies and their integration imply prospective food safety innovation for researchers and the food sector.
Contact Stress Analysis of Spur Gears and Performance Evaluation in Oat flake Rolling Machine
Authors: Ko Ko Chit , Win Htay Htay , Swe War War Min , Soe Aung Kyaw
Published: October 2024

This paper focuses on examining the structural integrity of spur gears within an oat flaking machine. This machine functions by compressing oat grains situated between a pair of horizontally aligned rollers. These rollers, set to revolve at a speed of 400 rpm and a gap of 0.45 mm, process the grains into flakes. The rotation of the rollers is facilitated by spur gears, which are propelled by a belt drive connected to an electric motor. Following a fractional rotation, the processed oats are ejected as flakes. The power transmission between gears occurs through the interaction of meshing teeth. The contact stress on the spur gear is determined using Hertz's theory, and the analysis of contact stress across two meshing spur gear teeth is executed with varying number of gear teeth via ANSYS software. The findings are delineated, and the results from finite element analysis simulations are juxtaposed with theoretical calculations. The theoretical values for effective stress and strain in contact stress analysis are 60.75 MPa and 0.51309×10⁻⁴, respectively, while simulation values are 61.78 MPa and 6.1846×10⁻⁴. Theoretical and simulation results are nearly the same. Therefore, the design is safe for oat flake rolling machine. The machine's performance was tested with 0.45 mm and 0.6 mm flakes over three days. For 0.45 mm flakes, the average capacity was 28.99 kg/hr with 99.46% efficiency, while for 0.6 mm flakes, it was 48.14 kg/hr with 99.73% efficiency. These results confirm that the machine operates reliably and efficiently at both settings.
Former des apprenti·e·s. À la rencontre des formateurs et formatrices en entreprise
Authors: Besozzi Roberta
Published: October 2024

26 juin 1930 : la première loi fédérale sur la formation professionnelle est promulguée, définissant le rôle des formatrices et formateurs en entreprise à l’échelle nationale. Aujourd’hui, nous observons en conséquence Carole préparer le plan de formation dans son bureau, Éric faire un gâteau avec ses apprenti·e·s dans son atelier, tandis que Dinh encadre les jeunes au laboratoire et que Luc donne des consignes à son apprenti dans l’entrepôt. Que savons-nous des personnes formatrices, actrices centrales du système de formation professionnelle initiale duale, mais souvent méconnues ? Une étude sociologique de 80 récits de formatrices et formateurs issu·e·s de différents métiers et secteurs professionnels révèle une diversité de rapport à la fonction selon quatre figures idéales-typiques : les « entrepreneur·e·s de soi », les « garant·e·s du métier », les « reconverti·e·s » et les « résigné·e·s ». Cet ouvrage explore les parcours de ces personnes, leurs façons d’investir leur fonction, selon leur ethos professionnel et les conditions dans lesquelles elles l’exercent, ainsi que les enjeux rencontrés au quotidien. Il offre des clés pour comprendre les visions de l’apprentissage et la relation de celui‑ci avec le marché du travail. Les résultats exposés permettront d’amener des actions plus ciblées.
Evaluasi Kinerja Cooling Tower Type Induced Draft Counter Flow Pada Sirkulasi Air Jernih Industri Baja
Authors: J Muh. Azis Albar , Asrina Asrina , Ardiansah Ardiansah , Nuhardin Irhamni
Published: October 2024

Cooling tower merupakan alat yang digunakan untuk melakukan penurunan temperatur air yang berasal dari area proses serta mengemisikan panas ke atmosfir. Pada proses produksi baja, sistem pendinginan sangat dibutuhkan dalam proses pencucian gulungan. Coling tower yang digunakan adalah type Induced Draft Counter Flow. Fungsi cooling tower ini yaitu memproses air panas yang berasal dari area proses untuk didingin sehingga dapat dipergunakan kembali. Cooling tower memiliki peranan yang sangat penting pada proses produksi oleh karena itu cooling tower harus memiliki kinerja yang efektif. Mengingat usia cooling tower telah lebih dari lima tahun maka perlu dilakukan evaluasi kinerja dari cooling tower tersebut untuk melihat seberapa besar penurunan kinerja cooling tower tersebut. Penelitian ini bertujuan untuk mengevaluasi kinerja cooling tower dengan cara menghitung nilai range, approach, efektivitas, kapasitas, evaporation loss, drift loss, blow down dan make up water. Dari hasil perhitungan kinerja cooling tower didapatkan nilai range sebesar 6,9°C–8,7°C, nilai approach sebesar 2,3-3°C, nilai efektivitas sebesar 71,96-78,70%, nilai kapasitas sebesar 8,10 m3/jam –10,26 m3/jam, dan nilai make up water sebesar 38,16 – 47,60 m3/jam. Berdasarkan hasil yang diperoleh telah mengalami penurunan kinerja sehingga perlu dilakukan perbaikan untuk memperoleh kinerja yang baik kembali.
Frameworks for Actioning Positive and Sustainable Change in Higher Education
Authors: Wood Lesley , Zuber-Skerritt Ortrun
Published: October 2024

This final chapter draws conclusions from an analysis of knowledge contributions gleaned from previous chapters to develop a consolidated framework for actioning positive and sustainable change in higher education (HE). Reiterating the argument of the book introduced in Chapter 1 that individuals and groups of people working in HE are best placed to initiate and bring about positive and sustainable change in their own practices, it begins with a recap of our thesis about why change is necessary, what needs to change, and how this change might best be brought about. The questions raised in the first chapter are then revisited, drawing insights from the ideas put forward by the various authors who contributed to this book. We then present a potential framework for actioning these ideas to bring about positive and sustainable change and close the chapter with some critical questions for readers to consider into the future.
Greenlighting the University: Re-envisioning the Role of Higher Education in Tackling the Climate Crisis through Action Research
Authors: Brydon-Miller Mary
Published: October 2024

Higher Education (HE) must take a leading role in addressing the current climate crisis. Universities have the capacity to provide the critical research and training to enable us to respond to the multiple environmental, economic, social, and cultural challenges this crisis creates. In order for this to happen, however, researchers will need to go beyond the confines of the academy to engage with government, industry, and civil society as active partners. Action research provides a model for researchers to expand their roles to include community relationship-building, collaborative design, and advocacy. Fortunately, there are already spaces within and outside HE where this reinvention is taking place. This chapter explores how we might use action research as a model to create universities prepared to take their part in addressing the climate crisis and contribute to the well-being of human beings and the planet.
Systemic Approaches to Transforming the University
Authors: Burns Danny
Published: October 2024

This chapter explores some of the problems of contemporary higher education (HE) and discusses how a more participatory perspective on knowledge and meaning-making can inform some of the changes that are needed in the world. It offers a model of inquiry as a way of stimulating and supporting the process of transformation that is needed in HE. It highlights the importance of multi stakeholder participatory processes, to understand the system dynamics that hold the status quo in place, and to change them.
Shaping Socially Responsible Higher Education Through Knowledge Democratisation
Authors: Hall Budd
Published: October 2024

Beginning with early influences, I share some background on my 60+ years of engagement with the world of higher education(HE). Sharing a world view deeply critical of the contemporary domination of global capitalism, I suggest that knowledge activism, knowledge democracy and questions of knowledge equity are key to the radical reinvention of HE that is needed. I go on to outline principles of socially responsible HE closing with a message of the urgency of our times
Prevention and treatment of transformation of myeloproliferative neoplasms to acute myeloid leukemia
Authors: Patel Anand A. , Rampal Raajit K.
Published: October 2024

Philadelphia-chromosome negative (Ph-neg) myeloproliferative neoplasms (MPNs) are hematopoietic stem disorders with a risk of progression to the accelerated-phase (AP) or blastphase (BP) that is influenced by clinical, pathologic, cytogenetic, and molecular variables. Overall survival is limited in MPN-AP/BP with current treatment approaches, particularly in those patients that cannot receive an allogeneic hematopoietic stem cell transplant (allo-HCT). In addition, long-term survival with allo-HCT is predominantly seen in chronic-phase MPNs which suggests that the ideal time for intervention may be before MPNs evolve to AP/BP. Over the course of this review we will focus on the risk factors for progression to MPN-AP/BP, identification of high-risk chronic-phase MPNs, potential early-intervention strategies, and considerations around the timing of allo-HCT. We will also summarize current survival outcomes in MPN-AP/BP, discuss the uncertainty around how to best gauge response to therapy, and outline clinical trial considerations for this patient population. Lastly, we will highlight future directions in the management of high-risk MPNs.
Genome sequencing in the management of myelodysplastic syndromes and related disorders
Authors: Cazzola Mario , Malcovati Luca
Published: October 2024

Myeloid neoplasms originate from the clonal proliferation of hematopoietic stem cells, which is driven by the acquisition of somatic genetic mutations. Within these disorders, myelodysplastic syndromes (MDS) are specifically characterized by morphologic abnormalities (dysplasia) and impaired maturation of myeloid precursors (ineffective hematopoiesis), resulting in peripheral blood cytopenia. Several studies have advanced the field of MDS, with a few landmark papers leading to a paradigm shift, opening new avenues of research and enabling a molecular revolution. These seminal papers include the first description of the 5q- syndrome, the identification of somatic mutations of TET2 in myeloid neoplasms, the detection of common pathway mutations in the splicing machinery, and the discovery of clonal hematopoiesis. The somatic genomic landscape of MDS is now well-defined. Genes that are recurrently mutated include epigenetic regulators, as well as genes of RNA splicing machinery, transcription regulation, DNA repair control, cohesin complex, and signal transduction. Furthermore, several disorders with a germline genetic predisposition to MDS have been identified, collectively accounting for up to 15% of all MDS cases. Genomic profiling can significantly improve the diagnostic approach to MDS, allowing the identification of distinct nosologic entities such as SF3B1-mutant or TP53-mutant MDS. The Molecular International Prognostic Scoring System for MDS (IPSS-M) has already proven to be a valuable tool for individualized risk assessment and treatment decisions. In addition, the recently developed molecular taxonomy of MDS will likely facilitate the implementation of precision medicine approaches for these disorders. This will necessitate the establishment of specialized infrastructures within public health systems, involving close collaboration between healthcare institutions, academia, and the life sciences industry.
Branching NOTCH1 to DNA damage in T-cell acute lymphoblastic leukemia
Authors: Kulkarni Tanaya , Herranz Daniel
Published: October 2024

Not available.
EKSISTENSI BUDAYA LOCAL DALAM PENDIDIKAN KARAKTER DI ERA MODERNISASI
Authors: Sadiana I Made , Rahmawati Ni Nyoman
Published: October 2024

Abstrak
 I Made Sadiana1, Ni Nyoman Rahmawati2
Universitas  Palangkaraya1, IAHN-TP Palangka Raya2
 made_sadiana@chem.upr.ac.id,  ninyomanrahmawati0202@gmail.com
Tujuan tulisan ini adalah untuk melihat eksistensi budaya lokal  dalam pendidikan karakter di era modernisasi. Pendidikan karakter merupakan hal yang sangat urgen dan penting bagi generasi muda di tengah kemajuan teknologi yang semakin cangih. Kemajuan ini tidak hanya memberi pengaruh positif tetapi juga negatif seperti semakin terkikisnya nilai-nilai moralitas bangsa sebagai akibat pengaruh budaya luar yang tidak sesuai dengan nilai luhur bangsa. Untuk membentengi generasi muda dari berbagai pengaruh negatif kemajuan teknologi.  Budaya Lokal sebagai salah satu tatanan nilai yang tumbuh dan berkembang di tengah masyarakat yang  berlandaskan pada ajaran agama, moralitas, pengalaman  turun temurun sangat penting dijadikan sebagai landasan moralitas dalam pembentukan karakter anak bangsa sehingga mereka tumbuh menjadi generasi muda yang berahlak mulia, berintegritas, religious, dan memiliki empati terhadap berbagai permasalahan yang terjadi di lingkungan sekitarnya. 
Kata Kunci: Eksistensi, Budaya Lokal, Pendidikan Karakter, Modernisasi
The Effect of 8-Week Soccer Training on Group Dynamics and Group Consciousness of Individuals with Intellectual Disabilities
Authors: Akarsu Gizem , Güven Erkan , Acar Nasuh Evrim , Sınar Ulutaş Derya Selda , Aslan Yunus Emre , Ağamolla Barış , Sabancalı Açelya , Eser Büşra , Erikli Eyüp
Published: October 2024

This study examines the effect of 8-week soccer training on group dynamics and group consciousness of individuals with educable intellectual disabilities. In this study, a one-group pretest-posttest model was used. The study included 8 male individuals aged 13-17 in a special education institution in Mersin province. Before and after the 8-week soccer training, 3 physical education teachers made independent observations and evaluated them with an observation form. According to the observation form pre-test and post-test mean scores, the % difference was calculated from descriptive statistics. When the pre-test and post-test percentage differences were examined; improvements were made in the areas of correct defense (40%), correct offense (40%), successful pass (40%), correct intervention (50%), goal to the opponent's goal (50%), ball control (60%), ball winning (50%), defensive error (20%), intervention to teammate (50%), goal to the wrong goal (20%), ball loss (40%) and team integrity (70%). As a result of the study, it was seen that long-term soccer training was beneficial in branch-specific skills, physical and mental development in individuals with intellectual disabilities. In addition, group consciousness was observed in individuals and behavioral changes occurred in this direction. Since there is a limited number of studies on group consciousness and group awareness in individuals with intellectual disabilities; it is thought that this study will contribute to the literature and guide future studies.
Ruptura de ligamento cruzado anterior: Manejo, propedêutica e diagnóstico
Authors: Moreira Douglas Ribeiro , Gomes Felipe Muniz , Ventura Renato
Published: October 2024

Introdução: Um dos fatores que contribuem para estabilização do joelho e sua função é o Ligamento Cruzado Anterior (LCA), que atua impedindo o deslocamento anterior, rotação interna da tíbia e hiperextensão e a ruptura de LCA é uma das lesões mais comuns. Objetivo: Compreender os mecanismos, ferramentas diagnósticas e estratégias terapêuticas. Metodologia: O estudo consiste de uma revisão de literatura conduzida em quatro etapas: identificação do tema e seleção da questão norteadora da pesquisa; estabelecimento de critérios para inclusão e exclusão de estudos e busca na literatura; avaliação dos estudos incluídos na revisão narrativa e interpretação e apresentação da revisão. Como critérios de inclusão, limitou-se a artigos escritos em inglês e português, publicados de 2018 ao ano de 2024. Discussão: Para o diagnóstico de ruptura de LCA, necessita-se de correlacionar a história clínica e o exame físico e, se necessário, exames complementares de imagem. Conseguinte ao diagnóstico, o tratamento tem por objetivo restaurar a funcionalidade do joelho, prevenir futuras lesões e osteoartrite e otimizar a qualidade de vida do paciente. Dessa forma, tem-se três principais opções para o tratamento: 1) reabilitação como primeira linha seguida de reconstrução do ligamento (RLCA); 2) RLCA e reabilitação pós-operatória e 3) reabilitação pré-operatória, RLCA e reabilitação pós-operatória. Pacientes de todas modalidades apresentam melhoras significativas na função do joelho e qualidade de vida. Considerações finais: a escolha do tratamento deve ser personalizada, visando não apenas a recuperação física, mas também a qualidade de vida e preferências do paciente.
Enamel hypoplasia: A defect in the organic matrix
Authors: Santos Júnior Marcio dos , Martins Vinicius Santos , Sobral Ana Paula Taboada , Ferri Elza Padilha , Santos Elaine Marcílio , Mendes Gustavo Duarte , Bussadori Sandra Kalil , Gonçalves Marcela Leticia Leal
Published: October 2024

Introduction: Aesthetics as an area within Dentistry has become fundamental, making it necessary to acquire knowledge beyond oral health, in order to promote confidence, self-esteem and well-being in patients, directly reflecting on their quality of life. The objective of this article is to present a study on enamel hypoplasia. Methodology: This article addresses dental enamel hypoplasia through a narrative review of the literature. Conclusion: Continuous advancement in knowledge and clinical techniques is crucial to improve the understanding, diagnosis and treatment of this condition, thus promoting better oral health for patients.
Decoding akathisia: The significance of dopamine and dopaminergic pathways - a case report
Authors: Lopes Mauro Marques , Pereira Gustavo Coutinho Nogueira , Veloso Bruna Carvalho , Anjos Yuri Costa , Silva Mariana de Sousa Vilela , Alves Fabiana , Vilela Bárbara Faria Corrêa , Ribeiro Edmar Geraldo , Rocha Vinícius Corrêa da Silva
Published: October 2024

Background: Dopamine and dopaminergic pathways are crucial in antipsychotic treatment and the emergence of akathisia. Understanding these mechanisms is essential for effectively managing this condition. Objective: This study aims to highlight the management of akathisia in a patient with schizophrenia while underscoring the significance of dopaminergic mechanisms in treatment. Methods: Following the CARE (CAse REports) guidelines, this study presents a case report that serves as a practical representation of clinical scenarios, contextualizing theoretical concepts through real-world examples, enhancing the understanding of rare conditions and unique treatment responses. Case Report and Discussion: A 59-year-old female patient diagnosed with schizophrenia developed severe akathisia after starting risperidone. She exhibited intense restlessness and emotional distress, requiring adjustments to her treatment regimen, including the addition of propranolol, clonazepam, and phenytoin. This case illustrates the intricate relationship between dopamine dysregulation and akathisia, emphasizing the necessity for personalized treatment strategies tailored to the patient's needs. It highlights the importance of close monitoring and flexible management in addressing adverse effects associated with antipsychotic medications. Furthermore, fostering a supportive therapeutic relationship with the mental health team and incorporating familial support significantly contributed to the patient's overall treatment success. Conclusion: Understanding dopaminergic pathways is vital for managing akathisia and schizophrenia. This study advocates for a holistic treatment approach that integrates clinical insights with psychosocial factors to improve the patient's quality of life and treatment adherence.
Influência da qualidade do sono nos parâmetros clínicos e laboratoriais em mulheres com síndrome dos ovários policísticos
Authors: Magalhães Luane Mascarenhas , Correia Hanna Vitória da Cruz , Resende Luana Teles de
Published: October 2024

Introdução: A síndrome dos ovários policísticos (SOP) é um distúrbio endócrino comum entre mulheres em idade reprodutiva, caracterizado por hiperandrogenismo, disfunção ovariana e morfologia ovariana policística. Objetivo: Descrever a influência da qualidade do sono nos parâmetros clínicos e laboratoriais em mulheres com síndrome dos ovários policísticos. Metodologia: Revisão integrativa, realizada na base de dados Public Medline (PubMed), com descritores DeCS/MESH “Polycystic Ovary Syndrome” e “Sleep”. Foram incluídos artigos disponíveis gratuitamente, com pesquisa realizada em mulheres com SOP de qualquer faixa etária, publicados nos últimos cinco anos, em português ou inglês. Resultados: Foram encontrados 66 estudos e, após o crivo metodológico, 5 foram incluídos na revisão. Ao total, 279 mulheres com idades variadas foram avaliadas, das quais aquelas com SOP e distúrbios do sono apresentaram alterações do índice de massa corporal, resistência insulínica, gordura hepática e maior triglicérides (TG). Conclusão: A presença de distúrbios do sono em mulheres com SOP está associada a alterações nos sintomas e parâmetros laboratoriais. Sugere-se, no entanto, a necessidade da realização de mais estudos para comprovar essa relação e os mecanismos específicos.
Assistência pré-natal: Exames complementares e sua importância
Authors: Malagoli Maria Eduarda Marques de Rezende , Silva Isabelly Cristina Pereira da , Santos Lethícia Mendes Silva e , Guimarães Iris Isabela da Silva Medeiros
Published: October 2024

A realização do pré-natal adequado promove o desenvolvimento saudável do bebê e permite a detecção precoce de doenças maternas e fetais, reduzindo os riscos de complicações obstétricas. Nesse sentido, os exames complementares empregados na prática clínica do pré-natal contribuem significativamente para avaliação da saúde da mãe e do bebê, prevenção e identificação precoce de doenças e diminuem as chances de óbito durante gestação. O presente estudo objetivou identificar a importância do acompanhamento pré-natal e a assimilação dos principais exames solicitados na prática ambulatorial da assistência do pré-natal, e para isso, foi feita uma revisão exploratória integrativa de literatura baseada em trabalhos publicados nos últimos 6 anos e manuais de 2012 e 2014, que abordassem o tema pesquisado e que estivem disponíveis eletronicamente em seu formato integral. Os principais exames a serem realizados na prática clínica do acompanhamento da gestação são: ꞵ-HCG, hemograma, tipagem sanguínea e coombs indireto, sorologias para doenças infecciosas, TSH, glicemia jejum e teste oral de tolerância à glicose e ultrassonografias. Dessa forma, é de suma importância a efetuação desses exames associado ao pré-natal regular com a finalidade de garantir uma assistência integral e qualificada e ofertar uma segurança materno-fetal.
Curva de disponibilidade de fósforo no solo
Authors: Franco Júnior Kleso Silva , Dias Márcio de Souza , Ribeiro Vinícius Muniz
Published: October 2024

Objetivou-se com esta pesquisa avaliar a eficiência de diferentes fontes de fósforo no desenvolvimento de milho (Hibrido Brevant B2401PWU) em um solo previamente cultivado com pastagens no município de Paraguaçu/MG. O delineamento foi em blocos casualizados com esquema fatorial 3x2, considerando três fontes de fósforo (Fosbio®BR, Fosfato natural, Mono Amônio Fosfato - MAP) e um controle, com e sem a presença de milho. O solo foi preparado e as parcelas, de 4 m², receberam tratamentos diferenciados para elevar o teor de fósforo a 15 mg/dm³. A semeadura do milho ocorreu em março de 2024, e as fontes de fósforo foram aplicadas logo após. A análise do solo foi realizada semanalmente, utilizando 10 subamostras por parcela para avaliar a disponibilidade de fósforo ao longo de oito semanas. Os dados foram submetidos a análise estatística pelo teste de Scott-Knott a 5% de probabilidade. Os resultados indicaram que o Fosbio®BR apresentou os maiores valores médios de disponibilidade de fósforo, especialmente nas semanas 2 e 3, sugerindo uma liberação controlada do nutriente, favorecendo o desenvolvimento do milho. O Fosfato natural mostrou uma rápida liberação inicial de fósforo, seguida por uma diminuição acentuada, o que indica uma menor eficiência ao longo do tempo. O MAP apresentou uma liberação moderada e estável de fósforo, enquanto os controles mantiveram baixos níveis de disponibilidade do nutriente, conforme esperado. Ressalta-se que apesar do Fosbio® ter dado bom resultado a dosagem é grande para aplicar e isso pode ser um complicador operacional e de custos.
Avaliação de um sistema de baixo custo para medir vazão
Authors: Araújo Gustavo Coêlho de , Ferreira Franz Berbert
Published: October 2024

A relação entre pressão, velocidade e posição relativa a um fluido em escoamento livre é descrita pela equação de Bernoulli. Apesar de suas restrições, este teorema possui aplicabilidade no ensino prático da disciplina mecânica dos fluidos através do experimento do jato livre. Sendo assim, o presente trabalho teve como objetivo avaliar a aplicabilidade de uma adaptação ao modelo feito em laboratório, utilizando garrafa pet e um sensor de vazão YF-S201, junto com uma placa Arduino UNO. A medição da vazão foi feita através do cálculo experimental e dos resultados obtidos pelo sensor quando a água atingisse uma altura de equilíbrio na garrafa. Foram coletados dezoito valores de altura e vazão. A taxa experimental encontrada para a altura de 15,6 cm (2,06 L/min) foi a mais próxima do valor marcado no sensor, 2,01 L/min. A maior divergência dos dados ocorreu para as alturas abaixo de 6,2 cm. Isto foi atribuído à baixa precisão do sensor YF-S201 e para pequenas alturas maior foi o erro produzido. No entanto, os dados obtidos foram aceitáveis, tendo em vista que apresentaram um desvio padrão de 0,54 L/min. Sendo assim, o modelo de medir vazão adaptado pode ser implementado no ensino remoto de disciplinas de engenharia.
Abordagens terapêuticas-intensivistas na tríade neonatal em pequenos animais: Revisão de literatura
Authors: Dias Denise Aguiar , Aragão Emilly Oliveira , Martins Amanda Emille Santana , Clímaco Maíra Santos Severo
Published: October 2024

A fase neonatal de cães e gatos é crítica devido à imaturidade dos sitemas orgânicos, tornando os neonatos suscetíveis à tríade neonatal (hipotermia, hipoglicemia e desidratação). A compreensão da fisiologia permite a detecção precoce de complicações que podem ser fatais se não tratadas prontamente. Objetivo: descrever a terapêutica para o manejo da tríade neonatal e atualizações, dada sua alta taxa de mortalidade. Metodologia: foi realizada uma revisão narrativa nas bases de dados Google Scholar e Scielo, utilizando palavras-chave como “tríade neonatal”, “hipotermia”, “hipoglicemia” e “desidratação” na neonatologia veterinária. Foram incluídos artigos publicados entre 2000 e 2023, abrangendo ensaios clínicos, estudos observacionais e livros especializados em clínica médica de pequenos animais. Resultados: as práticas eficazes incluem a manutenção da temperatura corporal com fluidos aquecidos (35-37ºC) e aquecimento por incubadoras (29,4-35ºC e umidade 50-65%). A hidratação deve ser feita com doses de 4 mL/100 g para cães e 2-3 mL/100 g para gatos, em bolus a cada 30 minutos ou por infusão contínua (0,5 mL/100 g/h). A correção da hipoglicemia envolve bolus de glicose 25% (1 mL/100 g), seguido de infusão contínua com glicose 2,5-5%. Conclusão: o manejo precoce da temperatura, glicemia e desidratação, incluindo seguridade imunológica, nutrição e a orientação ao tutor, é essencial para reduzir a mortalidade e melhorar a saúde dos neonatos.
Envelhecimento precoce bucal: Uma revisão de literatura
Authors: Oliveira Vanessa Sobreira de , Amaral Analice Maltezo , Santos Hísala Yhanna Florêncio Tristão
Published: October 2024

O envelhecimento precoce bucal (EPB) é uma condição que tem se tornado frequente entre jovens, caracterizada por manifestações clínicas que indicam um desgaste acelerado dos tecidos bucais, resultando em uma aparência envelhecida da cavidade oral. Como objetivo central, este estudo busca investigar as causas e possíveis associações do EPB com fatores ambientais e hábitos comportamentais. A pesquisa utilizou uma análise a partir do levantamento bibliográfico sobre o envelhecimento precoce bucal e seus fatores etiológicos. Os pacientes geralmente só identificam o EPB quando experimentam algum desconforto como a hipersensibilidade dentinária ou quando a estética é comprometida, levando a diagnostico tardio. Neste estudo, percebe-se que as causas e os fatores que impactam as características clínicas do Envelhecimento Precoce Bucal (EPB) exigem, para o tratamento adequado, a atuação não apenas da odontologia, mas também de outras áreas. Dessa forma, faz-se necessário que o cirurgião-dentista adote uma abordagem multidisciplinar, aliada a uma atenção especial à prevenção.
Multimodal Telegram Message Analysis: An Exploratory Study
Authors: Morrell Sara
Published: October 2024

Does the subject of Telegram messages impact message views? In this study, I examined the impact of text and image content on message view counts for messages sent between 15 February 2022 and 15 March 2022 in a Telegram channel associated with the Russian Imperial Movement (RIM). My goal was to examine how multimodal computational tools can be used to inductively explore online discourse associated with an extremist group.
Partisanship overcomes framing in shaping solar geoengineering perceptions: Evidence from a conjoint experiment
Authors: Magistro Beatrice , Debnath Ramit , Wennberg Paul O. , Alvarez R. Michael
Published: October 2024

The discourse on solar geoengineering (SG) is evolving, yet public perceptions of SG as a climate change solution remain underexplored, especially in the context of today's political polarization in the United States. We examine how different SG narratives—framed as complementary, substitutive, or posing a moral hazard—interact with partisan information sources to shape public attitudes. Using a conjoint experiment with 2,000 American voters, we find that partisan alignment with the information source strongly influences trust in the messenger and support for SG, overshadowing any impact of message framing. When co-partisan sources present information, both Democrats and Republicans are more likely to trust the communicator and support SG. Despite these partisan influences, policy preferences remain consistent with ideological baselines. These findings highlight the importance of political identity in shaping perceptions of emerging climate technologies like SG, even in contexts of low public awareness.
Algorithmic Model for Universe Formation: Detecting Cosmic Bugs in Expanding Space-Time.
Authors: Shekhar Sushant
Published: October 2024

This paper presents a novel algorithmic framework for modeling the formation and expansion of the universe, assuming space-time as a matrix composed of universal bits of space and time. Each space chunk carries information, encoded as universal bits, interacting dynamically to form the evolving space-time structure. The mathematical formalism includes functions that define the relationships between these space-time chunks, integrating non-additive operators to account for emergent phenomena at different scales. By computationally simulating the expansion of this space-time matrix, we introduce a bug detection system that flags anomalies—referred to as ”cosmic bugs”—such as Information Shift, Emergence of New Phenomena, NonAdditive Value behaviors, and Matrix Size Discrepancies. These bugs reflect the universe’s complex evolution and highlight potential deviations in the expected expansion model. Using this framework, we demonstrate the challenges of linking quantum mechanics, classical mechanics, and relativity, suggesting that computational complexities may arise due to these gaps in our current theories. The results show that as the universe evolves, various computational inconsistency emerge, suggesting at deeper physical principles that remain unexplained by existing models possibly due to universe being a simulation and 1 holds computational error or bug in it. The implications of this work extend to the understanding of space-time evolution, particle formation, and cosmological phenomena, raising questions about the completeness of the theories governing the behaviour of universe.
Hybrid “Quick-Deploy” Fabric Fairing to Reduce Drag in Trucks
Authors: Prabhu Aditya
Published: October 2024

Design of a flexible fairing that covers the gap between a truck and its trailer while still allowing free rotation about the trailer’s pivot axis. The fairing also allows for quick installation by implementing a combination of rigid structural rods linked to elastic fabric.
Classification by magnetic susceptibility and petrography of AIN BEN TILI 003
Authors: Garcia Jose , Pérez Sonia
Published: October 2024

Ain Ben Tili 003 is an ordinary chondrite found in the Maurita-nian Sahara desert that arrived at our laboratory on February 5, 2022. It is a unique stone of 189 grams (TKW), whose classification has been carried out through petrography and magnetic susceptibility techniques. It is an ordinary chondrite type meteorite, H6 S2 W2. Magnetic susceptibility measurements carried out with the “Met Met” instrument developed by Uehara et al 2023, support the classification.
Eco-Friendly and Cost-Effective Water Purification for Highly Polluted and Saline Sources Using Solar Powered Distillation and Activated Carbon.
Authors: Sikder Alman , Mumit Sayed Huzaifa
Published: October 2024

The research project focuses on addressing the household water crisis in Bangladesh by utilizing abundant water sources and energy resources. It involves developing and implementing a solar-powered distillation and activated carbon treatment system. By harnessing solar energy and local resources, the system effectively treats highly saline water bodies and arsenic-contaminated Tube-wells, mitigating the adverse effects of salinity and arsenic contamination in water sources. The project aims to provide clean and safe drinking water to households facing water scarcity and contamination. The study highlights the system's ability to remove pollutants, heavy metals, bacteria, viruses, and salinity, addressing the immediate needs of affected communities. By utilizing abundant energy resources and producing activated carbon locally, the project promotes resource optimization and sustainability. Additionally, the research findings indicate the system's versatility in treating various polluted water sources, demonstrating its potential for scalability and widespread adoption beyond arsenic-contaminated sources. This innovative solution has the potential to revolutionize water purification techniques and offer a sustainable remedy for global water-related challenges. The successful implementation of solar-powered distillation and activated carbon treatment systems has significant implications for solving the household water crisis in Bangladesh. By utilizing abundant resources, both in terms of water sources and energy, the project provides a practical and efficient approach to addressing water scarcity and contamination.
Evaluation of drop vertical jump kinematics and kinetics using 3D markerless motion capture in a large cohort
Authors: Templin Tylan , Riehm Christopher D. , Eliason Travis , Hulburt Tessa C. , Kwak Samuel T. , Medjaouri Omar , Chambers David , Anand Manish , Saylor Kase , Myer Gregory D. , Nicolella Daniel P.
Published: October 2024

Introduction

3D Markerless motion capture technologies have advanced significantly over the last few decades to overcome limitations of marker-based systems, which require significant cost, time, and specialization. As markerless motion capture technologies develop and mature, there is increasing demand from the biomechanics community to provide kinematic and kinetic data with similar levels of reliability and accuracy as current reference standard marker-based 3D motion capture methods. The purpose of this study was to evaluate how a novel markerless system trained with both hand-labeled and synthetic data compares to lower extremity kinematic and kinetic measurements from a reference marker-based system during the drop vertical jump (DVJ) task.

Methods

Synchronized video data from multiple camera views and marker-based data were simultaneously collected from 127 participants performing three repetitions of the DVJ. Lower limb joint angles and joint moments were calculated and compared between the markerless and marker-based systems. Root mean squared error values and Pearson correlation coefficients were used to quantify agreement between the systems.

Results

Root mean squared error values of lower limb joint angles and joint moments were ≤ 9.61 degrees and ≤ 0.23 N×m/kg, respectively. Pearson correlation values between markered and markerless systems were 0.67-0.98 hip, 0.45-0.99 knee and 0.06-0.99 ankle for joint kinematics. Likewise, Pearson correlation values were 0.73-0.90 hip, 0.61-0.95 knee and 0.74-0.95 ankle for joint kinetics.

Discussion

These results highlight the promising potential of markerless motion capture, particularly for measures of hip, knee and ankle rotations. Further research is needed to evaluate the viability of markerless ankle measures in the frontal plane to determine if differences in joint solvers are inducing unanticipated error.
Multivariable analysis for predicting lower limb muscular strength with a hip-joint exoskeleton
Authors: Kang Byungmun , Lee Changmin , Kim Dongwoo , Lee Hwang-Jae , Lee Dokwan , Jeon Hyung Gyu , Kim Yoonmyung , Kim DaeEun
Published: October 2024

Introduction

Advancements in exercise science have highlighted the importance of accurate muscular strength assessments for optimizing performance and preventing injuries.

Methods

We propose a novel approach to measuring muscular strength in young, healthy individuals using Bot Fit, a hip-joint exoskeleton, during resistance exercises. In this study, we introduced performance metrics to evaluate exercise performance during both short and extended durations of three resistance exercises: squats, knee-ups, and reverse lunges. These metrics, derived from the robot’s motor signals and sEMG data, include initial exercise speed, the number of repetitions, and muscle engagement. We compared these metrics against baseline muscular strength, measured using standard fitness equipment such as one-repetition maximum (1RM) and isometric contraction tests, conducted with 30 participants aged 23 to 30 years.

Results

Our results revealed that initial exercise speed and the number of repetitions were significant predictors of baseline muscular strength. Using statistical multivariable analysis, we developed a highly accurate model (R=0.884, adj. R2=0.753, p-value <0.001) and an efficient model (with all models achieving R>0.87) with strong explanatory power.

Conclusion

This model, focusing on a single exercise (squat) and a key performance metric (initial speed), accurately represents the muscular strength of Bot Fit users across all three exercises. This study expands the application of hip-joint exoskeleton robots, enabling efficient estimation of lower limb muscle strength through resistance exercises with Bot Fit.
The impact of cannabinoid receptor 1 absence on mouse liver mitochondria homeostasis: insight into mitochondrial unfolded protein response
Authors: Senese Rosalba , Petito Giuseppe , Silvestri Elena , Ventriglia Maria , Mosca Nicola , Potenza Nicoletta , Russo Aniello , Falvo Sara , Manfrevola Francesco , Cobellis Gilda , Chioccarelli Teresa , Porreca Veronica , Mele Vincenza Grazia , Chianese Rosanna , de Lange Pieter , Ricci Giulia , Cioffi Federica , Lanni Antonia
Published: October 2024

Introduction

The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.

Methods

We used CB1−/− and CB1+/+ male mice. Cytochrome C Oxidase activity was determined polarographically. The expression and the activities of separated mitochondrial complexes and supercomplexes were performed by using Blue-Native Page, Western blotting and histochemical staining for in-gel activity. Key players of Mitochondrial Quality Control processes were measured using RT-qPCR and Western blotting. Liver fine sub-cellular ultrastructural features were analyzed by TEM analysis.

Results and discussion

In the absence of CB1, several changes in the liver occur, including increased oxidative capacity, reduced complex I activity, enhanced complex IV activity, general upregulation of respiratory supercomplexes, as well as higher levels of oxidative stress. The mitochondria and cellular metabolism may be affected by these changes, increasing the risk of ROS-related damage. CB1−/− mice show upregulation of mitochondrial fusion, fission and biogenesis processes which suggests a dynamic response to the absence of CB1. Furthermore, oxidative stress disturbs mitochondrial proteostasis, initiating the mitochondrial unfolded protein response (UPRmt). We noted heightened levels of pivotal enzymes responsible for maintaining mitochondrial integrity, along with heightened expression of molecular chaperones and transcription factors associated with cellular stress reactions. Additionally, our discoveries demonstrate a synchronized reaction to cellular stress, involving both UPRmt and UPRER pathways.
Predicting the characteristics of a C2B6 monolayer with ultrahigh carrier mobility
Authors: Xu Ping , Zhu Zhengyang , Zheng Ruxin , Sun Qingyun , Ma Zhen , Mu Weihua , Cui Zhen
Published: October 2024

Two-dimensional materials have excellent electronic and optical properties, suggesting absolute advantages in nanodevices. In this work, a new two-dimensional material with a puckered structure, a C2B6 monolayer, is proposed. The material presents dynamic and thermal stability calculated by first-principle simulations. Interestingly, the C2B6 monolayer possesses semiconductor behavior with an ultra-narrow bandgap of approximately 0.671 eV by HSE06 functional. Meanwhile, the hole in the C2B6 monolayer shows ultrahigh mobility at approximately 6,342 cm2⋅V−1⋅s−1 in decent transport directions, which is larger than traditional transition metal dichalcogenides materials. More importantly, the pronounced anisotropy of mobility of the electrons and holes can separate the photogenerated charges, suggesting the applications for photocatalytic, photovoltaic and optical and cold chain electronic devices. Then, the novel properties of the light absorption characteristic are obtained, and the anisotropic photocurrent implies the C2B6 monolayer can be used as a potential photoelectric device. Our results provide theoretical guidance for the design and application of two-dimensional materials.
Prevalence and clinical significance of the genotypic carriage among ESBL phenotype-negative Escherichia coli and Klebsiella pneumoniae clinical isolates in bacteremia: a study in a Malaysian tertiary center
Authors: Lau Chee Lan , Neoh Hui-min , Periyasamy Petrick , Tg Abu Bakar Sidik Tg Mohd Ikhwan , Tan Toh Leong , Ramli Ramliza , Naina Mohamed Isa
Published: October 2024

Background

Antimicrobial resistance (AMR) can lead to fatal consequences. AMR genes carriage by phenotypically susceptible bacteria, such as Extended-Spectrum β-Lactamases (ESBL)s in Enterobacteriaceae, have potential implications for AMR spread and therapeutic outcomes. This phenomenon should be investigated.

Methods

Positive blood cultures from hospitalized patients in a Malaysian tertiary center between April 2022 and March 2023 were reviewed. A total of 137 clinical isolates of Escherichia coli (E.coli), Klebsiella pneumoniae (K.pneumoniae), and Klebsiella oxytoca were included. The antibiotic susceptibility and ESBL phenotypes were determined by disk diffusion method and the identification of genotypes by multiplex polymerase chain reaction. The clinical characteristics and outcome information were extracted by reviewing patients’ medical records to evaluate the clinical significance of the ESBL genotype-positive but phenotype-negative isolates in bacteremia.

Results

All 137 isolates were positive for at least one genotype (blaCTX-M, n = 71, 51.8%; blaSHV, n = 87, 63.5%; blaTEM, n = 95, 69.3%; blaOXA-1, n = 38, 27.7%). While blaCTX-M was proportionately higher in the ESBL phenotype-positive isolates than ESBL phenotype-negative isolates (33/37, 89.2% vs 38/100, 38%; p < 0.001), more than half of those harboring blaCTX-M remained susceptible to third-generation cephalosporins (3GC). The sensitivity (Sen) of blaCTX-M for ESBL phenotypes prediction was 89.19% (95% confidence interval [CI], 74.58 - 96.97%); however, specificity (Sp) was low (46.47%; 95% CI 39.75 - 53.32). The patient characteristics were similar among 98 ESBL phenotype-negative cases, except that the non-blaCTX-M carrier group had significantly more renal impairment (0/37 vs 7/61, p = 0.043) and gastrointestinal sources of bacteremia (9/37 vs 27/61, p = 0.047). No differences were observed in infection severity, in-hospital mortality, and length of stay (LOS) between the blaCTX-M and non-blaCTX-M carrier groups.

Conclusion

The current study provides insight into the gene carriage in E.coli and Klebsiella species clinical isolates, including blaCTX-M genotypes in antibiotic-susceptible strains from a Malaysian hospital. The ESBL encoding genotypes such as blaCTX-M presented substantially beyond one-third of the ESBL phenotype-negative or 3GC susceptible E.coli and K.pneumoniae isolated from bloodstream infection. Although clinical outcomes were not worsened with blaCTX-M genotype-positive but ESBL phenotype-negative isolates in bacteremia, the potential implications for AMR spread deserve further investigation.