bluuebunny/crossref_metadata_2025 huggingface dataset:
The Era of Digital Enablement: A Blessing or a Curse?
Authors: Mention Anne-Laure , Torkkeli Marko , Pinto Ferreira JJ
Published: December 2020

A few months ago, we claimed that COVID-19 had the potential to be a catalyst for change and innovation (Mention et al., 2020). Undeniably, this has indeed eventuated, but to a scale that was unforeseeable and unpredictable to many. Over the last few months, the world has literally changed. Around the world, people and communities have seen their lives put on a standstill, experiencing and experimenting with variable levels of restrictions preventing social interactions. We have learned what physical – rather than social, at least initially – distancing meant and have uncovered new ways of doing things. And that applied to almost for every single aspect of life. (...)
Profil hematologi mencit (Mus musculus L.) strain Balb/c jantan akibat paparan asap rokok elektrik
Authors: Utami Eva Tyas , Risqillah Ulfi , Fajariah Susantin
Published: December 2020

Electronic cigarette is one type of cigarette that are popular. This is because of the nicotine content in electronic cigarette liquid that can be regulated by the user so it is considered safe. The purpose of this study was to analize electronic cigarette effect on hematology profile of male Balb’C mice (Mus musculus L). This study used 24 males mice which were divided into 4 groups. Group 1 (control) was the group without electronic cigarette exposure. The group 2,3, and 4 were exposed to electronic cigarette for 1 ml, 2 ml and 4 ml liquid respectively. This study use liquid that containing 6 mg nicotin/ml. The exposure to electronic cigarette were conducted for 4 weeks. Hematology profile observation include hemoglobin level, erytrocytes count, count and types of leukocytes.The result showed that hemoglobin level and erytrocytes count was increase, leukocytes and lymphocyte count was decrease and no effect on granulocytes and MID after electronic cigarette exposure using different liquid volume. The conclusion of this study was  electronic cigarette exposure with different liquid volume as long as four weeks affect to Balb’C male mice hematology profile.
AKTIVITAS EFFECTIVE MICROORGANISMS (EM) DALAM TANAH PERTANIAN ORGANIK YANG TERPAPAR KLORPIRIFOS
Authors: Rizkiyanti D. , Wirajana I N. , Suyasa I W. B.
Published: December 2020

One way to restore soil fertility exposed to pesticides such as chlorpyrifos is by bioremediation using Effective Microorganisms (EM). The purpose of this study was to determine EM microbial resistance and chlorpyrifos degrading enzyme activity in organic farming soil sample.The organic farming soil sample used previously has been exposed to EM for a long time. This soil sample was divided into two treatments, namely sterilized by autoclaving and not sterilized (thus indigenous microbes remain alive). The next two soil samples were with and without addition of EM with incubation time of 3, 5, and 7 days. The results of this study indicated that EM microbes could withstand exposure to chlorpyrifos to a concentration of 56 ppm. The phenomenon of chlorpyrifos degrading enzyme activity was found in sterile soil samples with EM addition of 0.017 U/mL during 7-day incubation with a decrease in chlorpyrifos levels of 16.65%. The highest activity of chlorpyrifos degrading enzyme was found in unsterile soil sample, which amounted to 0.039 U/mL during the 3-day incubation period with a decrease in chlorpyrifos levels of 74.11%. The highest decrease in chlorpyrifos was found in unsterile soil sample by 80.04% with an incubation time of 5 days.

Keywords: chlorpyrifos, bioremediation, microbial EM (Effective Microorganisms)
SINTESIS MEMBRAN NATA DE PINA DAN APLIKASINYA UNTUK ADSORPSI ZAT WARNA TEKSTIL REMAZOL RED RB
Authors: Sukarta I N.
Published: December 2020

This study utilized pineapple peel waste into a membrane of nata de pina and used as an adsorbent for remazol red RB. The purpose of this study was to synthesis nata de pina membranes, determine the optimum pH, concentration and contact time of adsorption, isotherm pattern, and the maximum adsorption. The results indicated that cellulose nata de pina membranes were successfully synthesized and had the potential to become adsorbents for absorbing remazol red RB dyes. FTIR results showed that membrane nata de pina was a cellulose based membrane with swelling test result of 187.9%. The optimum conditions were at pH 2 with adsorption capacity of 17.12 mg/g, concentration of 80 mg/L with absorption capacity of 22.36 mg/g and contact time at 120 minutes with absorption capacity of 25.29 mg/g. The adsorption of remazol red RB dye has fulfilled the pattern of Langmuir adsorption isotherm with maximum adsorption of 0.0219 g/g or 21.9 mg/g adsorbent.

Keywords: Adsorption, Nata de pina, membrane, Remazol red RB
OPTIMASI PROPILENGLIKOL DALAM FORMULASI SIRUP EKSTRAK RIMPANG JAHE SEBAGAI OBAT BATUK
Authors: Artania A. I. , Harta I K. G. G. G. , Pratama G. W. A. P. , Ayu N. P. A. S. , Sukmarani I. G. A. P. , Arisanti C. I. S.
Published: December 2020

Ginger (Zingiber officinale) has a pharmacological effect to be an antitussive which has been proven empirically and through in vivo activity testing. The use of ginger directly has a spicy and bitter taste, so it is not very popular. Based on this, it is necessary to formulate it into syrup preparation which has met the physical stability test to obtain the best formula. In this study, ginger rhizome water extract that had been standardized and screened was formulated into syrup preparations. The formulation was carried out by optimizing the amount of propylene glycol as co-solvents and anti-cap locking which was 15, 20, and 25% of syrup preparation. The results showed that the concentration of propylene glycol in ginger rhizome extract syrup preparation affected the physical stability of the preparation. The three formulas obtained have not met the physical stability tests (pH and viscosity), but formula 3 with 25% of propylene glycol was the optimum formula of ginger rhizome syrup.

Keywords: Antitussives, Ginger (Zingiber officinale), Syrup, Propylenglycol, Viscosity

Rimpang jahe (Zingiber officinale) memiliki efek farmakologi sebagai antitusif yang telah dibuktikan secara empiris dan melalui uji aktivitas secara in vivo. Penggunaan jahe secara langsung memiliki rasa pedas dan getir sehingga tidak begitu disukai. Berdasarkan hal tersebut maka perlu diformulasikan ke dalam sediaan sirup yang telah memenuhi uji kestabilan fisik untuk memperoleh formula terbaik. Pada penelitian ini, ekstrak air rimpang jahe yang telah terstandar dan telah dilakukan skrining diformulasikan menjadi sediaan sirup. Formulasi dilakukan dengan optimasi jumlah propilen glikol yaitu 15, 20, dan 25% sebagai kosolven dan anti-caplocking terhadap sediaan sirup. Hasil yang diperoleh adalah konsentrasi propilenglikol dalam sediaan sirup ekstrak rimpang jahe berpengaruh terhadap stabilitas fisik sediaan. Tiga formula yang dikerjakan belum memenuhi persyaratan uji kestabilan fisik, namun formula 3  dengan 25% propilen glikol merupakan formula terbaik dari sirup rimpang jahe.

Kata kunci: Antitusif, Rimpang jahe (Zingiber officinale), Sirup, Propilenglikol, Viskositas
Pengaruh Aktivitas Eksklusif Sempadan Pantai Bagi Kehidupan Masyarakat Di Pantai Double-Six
Authors: Handayani Gracia Luciana , Sanjiwani Putri Kusuma
Published: December 2020

The tourism sector has a lot of impact on the economy of Badung Regency, especially in the Province of Bali even though, the ongoing activities of exclusive beach borders that are used for public spaces cannot yet be tolerated.As for the scope of the research, there are exclusive activities carried out by tourism entrepreneurs in the area of ??the beach that are used for exclusive activities, such as: tourist activities, community activities, activities of businesses in the field of tourism, viewpoints of tourists, viewpoints of people who live in villages. Seminyak customary, along with the regency-Badung regulations regarding exclusive activities on the coastline at DTW Double-Six Beach. techniques in collecting data in this study include observation, interviews, literature studies, and also documentation. The purposive sampling method is the technique of determining the informants used. The technique used in the cultivation of the report is a qualitative descriptive analysis. Exclusive activities at Sempadan Pantai carried out by tourism entrepreneurs include: K-Resto, Blue9Beach, The Sand Beach Bar&Grill, Capil Beach Grill&Bar, D’Joglo Beach Bar&Restaurant, The-Camplung Bar&Restaurant, La-Plancha, Bali Juice-Park, Taris-Bali, dan Chiringuito Bar-Grill- Restaurant. This exclusive activity also gives effect to the people who live around the Smeinyak Indigenous Village community, among others in terms of language, how to dress, building a business place, music flow, food and drink, and so forth. Tourism that comes is also presented with attractions that are present / modern

 

eyword: exculsive activity, impact, beach border, public area, double six beach
Strategi Pemasaran Wisata Kuliner Sebagai Destinasi Wisata Di Dili, Timor-Leste
Authors: Nheu Grace Deo Seldudes Eta , Sugiarti Dian Pramita
Published: December 2020

These project are done for  discussing the culinary tourist marketing at the tourism industry by identifying some of  East Timor’s traditional foods that could be developed as a culinary destination. Local culinary has a good potential to be developed and can be used as a tourist product to attract tourist for a pay visit in East Timor by the reason of foods and drinks diversity and in East Timor. The purpose of this project is to know the culinary tourist marketing as a tourism business and attract tourists in Dili, East Timor. Data gathering techniques which is used to collects in this project are observation, interview, and documentary studies and this project using primary and secondary data.  The study also employs qualitative data and will be analysis with qualitative techniques methods of marketing and is made up on four (4p) marketing structure. In this project has been used concepts that are related like marketing strategies, the culinary tours, the traditional foods, tourist destination, gastonomic theory, and marketing theory. The conclusion on these research are to discover certain local culinary potential that have been exploited as a culinary tourist destination. Tourist marketing that could developed tradional foods from East Timor should be give to East Timor’s sustainability.

Keywords :  Marketing Strategies, Culinary Tourism, Traditional Food.
Upaya Dinas Pariwisata Ternate Dalam Mengatasi Penurunan Kunjungan Wisatawan Di Daya Tarik Wisata Pantai Sulamadaha
Authors: Fabanyo Ayu Astrid , Sastrawan I Gede Anom
Published: December 2020

This study aims to determine the factors that cause a decrease in tourist visits and efforts made by the Ternate City Tourism Office in overcoming the decreasing intensity of tourist visits in Sulamadaha Beach Tourism Attractions. Ternate located in North Maluku Province. Ternate is one of 10 districts in North Maluku Province that have many tourist attractions, for example Sulamadaha Beach. Sulamadaha Beach is an attraction that is managed directly by the Ternate City Tourism Office and the local community, Sulamadaha Beach has beautiful underwater  natural beauty, according to data from the Ternate City Tourism Office Sulamadaha Beach is the most popular destination for tourists, but this does not last long as it is known from the data of tourist visits that Sulamadaha Beach every year has decreased, related to this, it will be research about  "The efforts of the City of Ternate Tourism Office in Overcoming the Decreasing Intensity of Tourist Visits in Sulamadaha Beach Attractions"

The research method used in this study is the type of research is descriptive research with a qualitative approach. The results of this study indicate that there are several factors that cause a decrease in the intensity of tourist visits in Sulamadaha Beach Tourism by using the concept of Sapta Charms, namely safe factors, orderly factors, and friendly factors, Ternate City Tourism Office has also designed several programs to stabilize the problem. One of the efforts made by the agency is to add supporting facilities to tourist attractions.

Keywords :efforts, decline
Analisis Potensi Ekowisata dan Kesiapan Masyarakat Desa Rendu Tutubadha dalam Pengembangan Ekowisata
Authors: Aja Adriano Filemon , Arida I Nyoman Sukma
Published: December 2020

Tourism trend and tourist motivation changes dynamically since the first time development of tourism. Mass tourism is one of tourism trend which grow Praccessibility, etc) and tour with a big group. Ecotourism appears in the early of 1990, ecotourism can be defined as a responsibility journey to a natural place. The aim is to make empowerement in the local society, conservancy, and the preservation of local society’s culture. Ecotourism grows fastly because this trend is different from conventional tourism which dominates. Rendu Tutubadha village locates in Aesesa District, Nagekeo Regency, East Nusa Tenggara Province has a big potential of ecotourism. Ecotourism potentials in this village consists of natural hot spring of Ae Petu Meze, Lambo Mountain, traditional village and etu ritual. Develop these ecotourism potentials needs readiness of Rendu Tutubadha’s society so the development will hold by the ecotourism principals and give positive effect to the society in eceonomis and other aspect. This research using primary and secondary data, quantitative and qualitative data is also used in this research. Data collecting method is interview, literature study, and observation. Qualitative descriptive used to presents the research result. This research finds some ecotourism potenstials in Rendu Tutubadha village. The ecotourism potential is nature and culture potential. The nature potential is like natural hot spring of Ae Petu Meze and Lambo Mountain, besides of that there are two culture potentials like traditional village of Rendu Tutubadha and Etu ritual. This research also finds that Rendu Tutubadha’s society readiness is enough to develop ecotourism, it can be seen in the society’s traditional life, although there are some aspects of ecotourism needs to fixed

Keyword: ecotourism potential, ecotourism, society readiness
Partisipasi Masyarakat Lokal Dalam Pengelolaan Daya Tarik Wisata Air Terjun Sipiso-piso Kabupaten Karo, Sumatera Utara
Authors: Sitanggang Louis Steven , Sugiarti Dian Pramita
Published: December 2020

Sipiso-piso Waterfall located in Karo District, North Sumatra can be used as a superior attraction because it has great potential to be developed compared to other attractions around Lake Toba because this waterfall is one of the most popular tourist attractions. However, there are several obstacles on the development of Sipiso-piso Waterfall tourism such as tourism stakeholders who do not cooperate well such as the provision of supporting facilities that should be provided by the tour manager, namely the Karo District government instead, provided by the local community. Based on this phenomenon, it is necessary to know the management of Sipiso-piso Waterfall and how much participation of local people in the management of Sipiso-piso Waterfall.

The method used in this research is descriptive qualitative. This research aims to To find out how to manage Sipiso-piso waterfall in Karo District, North Sumatra To find out how far the participation of local people in the management of Sipiso-piso waterfall. Data collection techniques using observation, interviews, and literature. Determination of informants using Purposive Sampling techniques. The results of this research is that the  community in the management of Sipiso-Piso Water Tourism Attraction at the planning stage is at the encouraged participation type, at the community organizing stage is at the spontaneous participation as well as at the mobilization stage, while at the community supervision stage is at the encouraged participation type.

 

Keywords: participation, development, local community
Agrowisata Berkelanjutan Berbasis Kopi di Satria Agrowisata Desa Manukaya, Kecamatana Tampak Siring, Kabupaten Gianyar, Bali (Studi Evolusi Pariwisata)
Authors: Azizah Febrytha Nur , Anom I Putu
Published: December 2020

Agro-tourism is an alternative tourism activity that relies on plantations and agriculture as its main attraction. Along with the development of tourism, agro-tourism has now become an economic driving commodity for the surrounding community, so that agro-tourism is increasingly taken into account in the world of tourism. The development of an agro-tourism can not be separated from the evolutionary process that occurs through various stages of the beginning of the tourist attraction built until now. This study aims to determine the evolution of developments in Satria Agrowisata. The research method used is descriptive qualitative by conducting data collection techniques through online interview as primary data, and conducting online observations as secondary data. The results show that Satria Agrowisata can adapt well to the various changes that exist and continue to innovate in order to survive in the world of tourism until now. In Darwin's theory of evolution, he put forward two key words in his theory, natural selection and adaptation. Natural selection as a mechanism for evolutionary change, and adaptations that occur in its development over time.

 

Keyword: Evolution, Agrotourism, Satria Agrowisata, Bali.
Persepsi Pengunjung Domestik Terhadap Wisata Entertainment di Daya Tarik Wisata Kawasan Luar Pura Uluwatu
Authors: Tjampan Kesya Marcella , Nugroho Saptono
Published: December 2020

The strategy forming tourist attraction to attract repeating guest is by developing entertainment tourism which offers sense of pleasure, satisfaction, and valuable experience. Uluwatu Kecak Fire Dance in Outer Area Uluwatu Temple was recognized as the most famous entertainment forms by domestic visitors. This aim of study is to identifying characteristics and measuring perception of domestic visitors to Uluwatu Kecak Fire Dance based on seven operational dimensions of entertainment tourism (Learning, Enjoyment, Escape, Refreshment, Novelty, Involvement, and Local Culture). The research used qualitative method with data collection techniques are questionnaire (number of samples were 65 respondents) and literature study. The data analysis technique used descriptive statistical analysis with continuum lines. The results showed that the perception of 65 domestic visitors for entertainment tourism in Uluwatu Temple were strongly agreed on Learning (277.5) and Enjoyment (285). While perception that were agreed are Escape (227), Refreshment (248.5), Novelty (259.25), Involvement (266), and Local Culture (272.33). In determining the dominant indicators of each dimension of entertainment tourism, the author uses the highest frequency capacity value. The three dimensions with highest average value are Enjoyment (285), Learning (277.5), and Local Culture (272.33). The administrator Outer Area Uluwatu Temple emphasize strategies that can maintain the three dimensions of entertainment tourism that have a dominant value, which is the Enjoyment dimension, Learning dimension, and the Local Culture dimension.

 

Keyword: Visitor Perception, Socio-demographic Characteristics, Entertainment Tourism, Domestic Visitors
Alternative viewpoints on the nature and importance of a prominent syncline at the northeastern edge of Wyoming’s Hanna Basin
Authors: Lillegraven Jason A.
Published: December 2020

The geologic history of Wyoming’s Hanna Basin is still being written. Surprisingly, here appeared an opportunity to share insights from previously accomplished work with that conducted anew by other scholars. The area of study was in the southeastern quadrant of Wyoming, which exhibits the state’s most complex history with respect to the Laramide orogeny. Especially important for present purposes were the tectonic conditions of the late Paleocene and earliest Eocene, recorded within the Hanna Formation. Of central focus is the 2020 publication by Dechesne and her six co-authors. Geographically, the landscape they covered was a thin, synclinal slice of the northeastern margin of the Hanna Basin. Key goals for the present publication have been to illustrate positive linkages and to highlight discrepancies between Dechesne et al. (2020) and relevant prior geological work. A concern that permeates all facets of this approach is the ability to verify viability of brand-new geologic descriptions, data, and resulting conclusions. Essential graphical elements were introduced first into this present publication. Once that package of background information was available, more focused analyses were rigorously pursued on diverse issues within the Dechesne et al. (2020) publication. Dechesne’s team presented a significantly modified but adequately defended approximation of the Paleocene–Eocene boundary. Data from fossil plants (macro- and palynofloras), continental mollusks, and bulk organic-carbon isotopes all agree within one measured section (of five sections studied) with an approximated Paleocene–Eocene boundary along with a ‘carbon isotope excursion’ (CIE). Strength of available evidence seems questionable, however, in that the inordinately high variability in bulk organic carbon (characteristic of a CIE) has been demonstrated only in the Hanna Draw Section. Although fluvial, paludal, and lacustrine facies are considered in several contexts, in no sense does the publication’s organizational form provide a ‘detailed stratigraphic framework.’ One zircon-based U–Pb depositional date (54.42 ± 0.27 Ma) came from this study that matched early Wasatchian time. Participants in the Dechesne et al. (2020) project are to be commended in that their resulting paper ranged broadly across the geologic setting, stratigraphy, paleocurrents, paleobotany, continental mollusks, zircon geochronology, associated lithofacies, and paleogeography. Despite that breadth, there exists a plethora of unexpected and wholly avoidable inconsistencies, strong contradictions within what should be homogeneous datasets, and seemingly inexplicable omissions of obviously necessary and sometimes clearly existing but unutilized data, one must question the reliability of much of the information presented in their paper.
Eruption cyst in a patient with microcephaly: a case report
Authors:   Brazilian Dentistry Association, Sergipe Section, Aracaju, SE, Brazil, Couto Graziane ,   Department of Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil, Lima Cyntia ,   Brazilian Dentistry Association, Sergipe Section, Aracaju, SE, Brazil, Moura Ana ,   Brazilian Dentistry Association, Sergipe Section, Aracaju, SE, Brazil, Amaral Regiane ,   Department of Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil, Gutierrez Gabriela ,   Brazilian Dentistry Association, Sergipe Section, Aracaju, SE, Brazil,   Department of Dentistry, Federal University of Sergipe, Aracaju, SE, Brazil, Barros Alina ,   Brazilian Dentistry Association, Sergipe Section, Aracaju, SE, Brazil,   Diagnostic and Dental Unit for Patients with Special Needs, Federal University of Sergipe, Aracaju, SE, Brazil
Published: December 2020

The aim of this paper is to report the clinical case of a 3-year and 7-month-old male child with microcephaly who had multiple eruption cysts, and to discuss the adopted procedures. The diagnosis of eruption cyst was concluded based on the clinical and radiographic characteristics. The treatment proposed was a surgical incision of the eruption cysts with the patient under general anesthesia. However, due to health reasons, the patient could not have the procedure performed, and, after four months, seven of the eight eruption cysts had regressed with teeth eruption; therefore, no surgical intervention was needed. Regarding the remaining eruption cyst, the therapy adopted was his mother monitoring the condition. It is possible to personalize eruption cyst treatment by monitoring the lesion until its eventual spontaneous disappearance, without any type of intervention.
Transient Brugada-like ECG pattern incited by uncontrolled hypertension - a rare case report
Authors: Parajuli Priyanka , Bhattarai Mukul , Lara-Garcia Odalys Estefania , Regmi Manjari Rani , Maini Ruby , Sambandam Alarmelu , Kulkarni Abhishek
Published: December 2020

Background:

Brugada syndrome (BrS) is a rare form of channelopathy caused by mutation of SCN5A gene that encodes for sodium channel and is associated with increased risk of ventricular arrhythmia and sudden cardiac death. BrS has a characteristic electrocardiographic (ECG) pattern. Various stressors can induce Brugada-like patern on ECG in the absence of BrS known as Brugada phenotype.

Case Presentation:

We report a case of a 28-year-old African-American male patient who presented to the emergency department with a chief complaint of atypical chest pain. He was noted to have an elevated blood pressure and a type 1 Brugada patern on his 12-lead ECG. His ECG changed from type 1 to type 3 Brugada patern upon controlling blood pressure, which indicated the presence of a Brugada phenocopy.

Conclusion:

It is important to recognize the underlying stressors that can lead to Brugada-like patterns on the ECG since these stressors are treatable without any sequel.
TORAKAL SEMPATEKTOMİ ETKİNLİĞİNİN AVUÇ İÇİ ISI ÖLÇME YÖNTEMİYLE İLİŞKİSİ
Authors: DURAL Koray , ÖZPOLAT Berkant , GÜNAL Nesimi , ZORLU Ekin , KÜR Salih
Published: December 2020

Amaç: Hiperhidroz kişinin sosyal yaşam kalitesinde ciddi bozulmaya ve psikolojik sorunlar oluşmasına yol açan, özellikle yüz, aksilla, palmar ve plantar bölgelerde yoğunlaşmış, normal fizyolojik ihtiyaçtan ve termoregülasyon için gerekenden daha fazla miktarda ter salgılanması olarak tanımlanmaktadır. Hiperhidroz tedavisinde topikal tedaviler, sistemik ilaçlar, iyontoforez, botulinum toksini enjeksiyonu, radyofrekans uygulamaları, psikoterapi veya cerrahi gibi çeşitli tedavi yöntemleri yer almaktadır. Her bir yöntemin kendine özgü farklı avantajları, dezavantajları, yan etkileri veya komplikasyonları bulunmaktadır. Tedavide günümüzde altın standart olarak kabul edilen ve kalıcı etki elde edilen tedavi şekli torakoskopik olarak yapılan sempatik blokajdır. Torakal sempatektominin sempatik sisteminin periferik vazodilatatör etkisiyle avuç içindeki ısıyı da artıracağı öngörüsüyle araştırmasını yapacağımız bu yöntemle sempatektomi seviyesini ve alanını sınırlı tutarak yan etkileri azaltabileceğimizi öngördük.Gereç ve Yöntemler: Çalışmamızda Endoskopik Torakal Sempatektomi (ETS) uyguladığımız 21 hastada sempatik zincir bütünlüğünün kaybedilmesinin hemen öncesinde ve sonrasında avuç içi ısı değerleri ölçülerek istatistiki karşılaştırmaları yapıldı.Bulgular: Torakal sempatik zincir bütünlüğünün bozulması sonrası ölçülen avuç içi ısılarında müdahale öncesine göre istatistiksel olarak anlamlı artış bulundu.Sonuç: Operasyon esnasında avuç içi ısı takibi ETS’nin lokalizasyonun doğruluğunu takipte ve yan etkilerinin azaltılmasında kullanılabilir.
LYSOSOMAL STORAGE DISEASES: KIRIKKALE UNIVERSITY EXPERIENCE
Authors: BÜLBÜL Selda , ÇELİK Cansu , ALPCAN Ayşegül
Published: December 2020

Objective: Lysosomal storage diseases which were first described in 1880; are important group of metabolic disorders characterized by the deposition of the substrates in lysosomes due to defects of the activity or transport of lysosomal enzymes or a defect in the receptor proteins. LSDs usually show a progressive clinical course and may not be represented with any clinical signs during the neonatal period. The overall prevalence of LSDs is 1 / 7000-8000. The aim of this study was to share the clinical characteristics of our LSDs patients and the experiences of our pediatric metabolic diseases department.Material and Methods: This retrospective cohort study was conducted at Kırıkkale University Hospital with 56 patients diagnosed as lysosomal storage disease among 315 patients diagnosed with metabolic diseases. Data were collected from outpatient clinic patient files who were diagnosed between 2011- 2018. Results: A total of 315 patients diagnosed with inherited metabolic disease were followed in our clinic and 56 (17.7 %) of them were diagnosed as LSDs. The 56 patients were suffering from the following diseases: 10 patients with Mucopolysaccharidosis, 1 patient with mucolipidosis type 2 (I-cell disease), 41 patients with sphingolipidoses, two patients with cystinosis, one patient with Infantile Pompe Disease and one patient with beta-mannosidosis.The mean age of the patients with Fabry Disease and the other patients diagnosed with other LSDs were 34.7±14.2 years (minimum 8, maximum 64) and 2.67±3.4 years (minimum 0, maximum 10.5) respectively. All diagnoses were verified by specific enzyme analysis and/or by conducting genetic mutation analysis. Conclusion: The most common lysosomal storage disease among our patients were Mucopolysaccharidosis and sphingolipidosis. Treatment options, such as enzyme replacement therapy and bone marrow transplantation exist, and 24 of these patients are receiving enzyme replacement therapy.
Does Diabetes increase Joint Pain? - A Review
Authors:   Newcastle Under Lyme, Ghosal Shraboni
Published: December 2020

Diabetes mellitus (DM) consists of a group of metabolic diseases characterized by hyperglycaemia or elevated levels of blood glucose. People with diabetes suffer from a number of disorders that can cause dysfunction and joint pain, which can reduce their quality of life. The aim of this review is to discuss if diabetes increases joint pain. This review also looks at the mechanisms through which diabetes contributes to joint pain.
Molecular Association of Coronavirus with Diabetes Mellitus Type 2 in Pakistan
Authors:   University Of The Punjab, Riaz Samreen
Published: December 2020

Patients with COVID-19 who have elevated blood sugar levels without a previous diagnosis of diabetes may be at a high risk of death and an increased risk of severe complications from the infectious disease, a new study says. We aimed to briefly review the general characteristics of the novel coronavirus (SARS-CoV-2) and provide a better understanding of the coronavirus disease (COVID-19) in people with diabetes, and its management.
Community Art Projects Beyond Borders
Authors: Serjouie-Scholz Ava , Ferreira Celia
Published: December 2020

This essay describes a community art project between primary school children in Iran and Portugal. The students designed and painted individual Tiles with a letter written in English as a gift for each other.
الأثار القانونية لتغير سيادة الدولة على الحقوق المكتسبة للأفراد الأجانب
Authors: Ahmad Bin Issa
Published: December 2020

لما كانت الحقوق المكتسبة للأفراد الأجانب تتأثر بتغير السيادة على الدول. لذا أقرت المواثيق الدولية إلزام إعمال المبادئ العامة للقانون الدولي خاصة ما تعلق بالممتلكات لأنها حقوق مكتسبة للأفراد الأجانب في ظل سيادة دولة سابقة قبل أن تحل محلها سيادة دولة أخرى.

إلا أن معظم الدول لم تلتزم بذلك وقامت بإستعادة وتأميم الممتلكات الأجنبية وهذا ما كان في حالة الجزائر كدولة مستقلة.
Ticagrelor alleviates sepsis-induced myocardial injury via an adenosine-dependent pathway in a mouse sepsis model
Authors: Tang Shengxing , Fu Cong , Xu Qiancheng , Guo Wenjun , Cao Yuhan
Published: December 2020

Purpose: The purpose of this study was to determine whether ticagrelor, a classic anti-platelet drug, has a therapeutic effect on sepsis-induced myocardial injury.

Methods: The C57BL6J mice received oral ticagrelor (10, 25 and 50 mg/kg) for seven days after which cecum ligation and puncture (CLP) were performed. An adenosine-receptor antagonist (CGS15943) was administered two hours before CLP. After 24 h, cardiac function was measured using cardiac echocardiography, then the heart and blood were collected. Hematoxylin and eosin (HE) staining and terminal deoxynucleotidyl transferase

dUTP nick end labelling (TUNEL staining) were used to observe pathological changes and cardiomyocyte apoptosis. Plasma concentration of TNF-α, IL-6 and adenosine and myocardial tissue levels of TNF-α and IL-6 were determined. Survival analysis was performed. Western blot was used to determine the expression of a signalling protein in the myocardial tissue.

Results: The HE and TUNEL staining showed less inflammatory cell infiltration and less cardiomyocyte apoptosis in the ticagrelor group. Cardiac echocardiography showed preserved heart function in the ticagrelor group. Plasma TNF-α, IL-6 and relative expression of TNF-α and IL-6 in myocardial tissue were significantly lower in the ticagrelor group. Plasma adenosine levels were significantly higher in the ticagrelor group. Adenosine-receptor antagonists significantly blocked the protective effect of ticagrelor. Ticagrelor reduced the mortality of sepsis mice, and this reduction was blocked by the adenosine-receptor antagonist. Western blot showed that ticagrelor activated the phosphorylation of AKT and mTOR. Adenosine-receptor antagonists inhibited the activation of AKT and mTOR.

Conclusion: The protective effect of ticagrelor was dependent on adenosine-receptor activation, with downstream upregulation of phosphorylation of AKT and mTOR.
Effect of melatonin on regeneration of cortical neurons in rats with traumatic brain injury
Authors: Ge Jianbin , Chen Dandan , Ben Jingjing , Song Xinjian , Zou Linqing , Yi Xin
Published: December 2020

Purpose: To investigate the effect of melatonin on regeneration of cortical neurons in rats with traumatic brain injury (TBI).

Methods: Sprague-Dawley rats (n=36) were randomly divided into sham, TBI+vehicle and TBI+melatonin groups. Cerebral blood flow and cognitive function were observed via laser Doppler flowmetry and by Morris water maze testing, respectively. The serum malondialdehyde (MDA) and superoxide dismutase (SOD) levels were used to assess oxidative stress. Immunofluorescence and terminal deoxynucleotidyl transferase dUTP nick end labelling assay was used to observe the newborn neurons and apoptotic cells.

Results: Cerebral blood flow in the TBI+melatonin group was higher than that of the TBI+vehicle group at one, 12, 24 and 48 h post-injury, but the difference was not statistically significant (P>0.05). The cognitive function of the rats was better in the TBI+melatonin group than the TBI+vehicle group (P
Association between APE1 ASP148GLU and colorectal cancer risk: A meta-analysis
Authors: Lin Caizhao , Jin Yuewei , Cheng Shaobing , Wang Weibing
Published: December 2020

Background: Colorectal cancer (CRC) is recognized as one of the most common cancer globally. The association between CRC and apurinic endonuclease 1 (APE1) Asp148Glu polymorphism remains unclear; thus, this meta-analysis aimed to explore whether APE1 Asp148Glu polymorphism is related to CRC risk.

Methods: Embase, PubMed, Cochrane library, CNKI and Wanfang databases were subject to a systematic search until April, 17, 2020 to evaluate the effect of APE1 Asp148Glu polymorphism on CRC risk. The associated strength was used to evaluate with odds ratios (ORs) with 95% confidence intervals (CIs) between Asp148Glu polymorphism and CRC risk. Subgroup analyses were also performed.

Results: In total, 11 articles including 8,136 subjects (3,836 cases and 4,300 controls) were included. Five genetic models were analyzed, including the additive model (G vs. T), the heterozygote comparison (TG vs. TT), the homozygote comparison (GG vs. TT), the dominant model (TG+GG vs. TT), and the recessive model (GG vs. TG+TT). In these models, T refers to thymine and G refers to guanine. The APE1 Asp148Glu polymorphism in heterozygote comparison [OR (95%CI) = 1.36 (1.05, 1.75), P=0.019] and dominant model [OR (95%CI) =1.31 (1.07, 1.61), P=0.010] significantly increased CRC risk. No significant association was seen for the additive model [OR (95%CI) = 1.14 (1.00, 1.31), P=0.057], recessive model [OR (95%CI) = 0.97 (0.71, 1.31), P=0.826] or in homozygote comparison [OR (95%CI) = 1.15 (0.88, 1.52), P=0.309]. Moreover, CRC risk indicated a remarkable association with APE1 Asp148Glu polymorphism in the PCR-RFLP additive model, homozygote comparison and recessive model (PG) may be a potential risk factor for CRC.
The Social Construction of News Automation and the User Experience
Authors: Dierickx Laurence
Published: December 2020

This paper examines the role of the social representations and cultural practices of journalists in shaping the uses (and non–uses) of news automation software as a tool to support journalism practices. It is approached through an empirical study conducted within two newsrooms in French–speaking Belgium, where we have followed the process of a socio–technical construction involving journalists in the design process. This first form of use led the journalists to reconfigure their professional practices, placing the accent on the necessity of shaping a tool that will reproduce their know-how. Still, automated news will only make sense through journalistic mediation.Este artigo examina o papel das representações sociais e práticas culturais de jornalistas na modelagem dos usos (e não–usos) do software de automação de notícias quando considerado como uma ferramenta de apoio às práticas do jornalismo. É fundamentado em um estudo empírico realizado em duas redações na Bélgica francófona, onde seguimos o modelo de uma construção sociotécnica que envolveu jornalistas no processo de design. Essa primeira forma de uso levou os jornalistas a reconfigurar suas práticas profissionais, enfatizando a necessidade de moldar uma ferramenta que reproduza seu know–how. Ainda assim, as notícias automatizadas só farão sentido através da mediação jornalística.Este artículo examina el papel de las representaciones sociales y las prácticas culturales de los periodistas en el modelado de los usos (y no usos) del software de automatización de noticias cuando se considera como una herramienta para apoyar las prácticas periodísticas. Se basa en un estudio empírico realizado en dos salas de redacción en Bélgica francófona, donde seguimos el modelo de una construcción socio–técnica que involucró a periodistas en el proceso de diseño. Esta primera forma de uso llevó a los periodistas a reconfigurar sus prácticas profesionales, enfatizando la necesidad de dar forma a una herramienta que reproduzca sus conocimientos. Aun así, las noticias automatizadas solo tendrán sentido a través de la mediación periodística.
Data-Driven Journalistic Operation: Reshaping the Idea of News Values with Algorithms, Artificial Intelligence and Increased Personalization
Authors: Dos Santos Márcio Carneiro
Published: December 2020

This article discusses the strategic reconfiguration of data in news organizations through the use of algorithms and artificial intelligence, more specifically machine learning, to increase the idea of value around information, which has suffered from fragmented audiences, a massive increase in the number of broadcasters, indirect competition from large technology companies, and changes to the digital media ecosystem. We propose to identify patterns of interest, predict social engagement, and allocate resources for new coverage as forms for increasing the current level of personalization offered to news consumers.Discute-se a reconfiguração estratégica da utilização de dados dentro das organizações jornalísticas, através de algoritmos e soluções de inteligência artificial, entre elas especificamente o aprendizado de máquina, como alternativa para elevação da percepção de valor sobre o produto informativo, reduzida pela fragmentação das audiências, explosão de emissores, concorrência indireta das grandes empresas de tecnologia e transformações do ecossistema de meios digitais. Tal abordagem propõe a identificação de padrões de interesse, a predição de engajamento social e a alocação de recursos para coberturas como formas de expandir o atual nível de personalização oferecido aos consumidores de notíciaSe discute la reconfiguración estratégica del uso de datos en las organizaciones periodísticas a través de algoritmos y soluciones de inteligencia artificial, específicamente, el aprendizaje automático como una alternativa para aumentar la percepción de valor sobre el producto de información, el cual se reduce por la fragmentación de las audiencias, el aumento en la cantidad de emisores, la competencia indirecta de grandes compañías tecnológicas y las transformaciones del ecosistema de medios digitales. Tal enfoque propone la identificación de patrones de interés, la predicción del compromiso social y la asignación de recursos para la cobertura como formas de expandir el nivel actual de personalización ofrecido a los consumidores de noticias.
Who Controls the Voice? The Journalistic Use and the Informational Domain in Vocal Transactors
Authors: Fagundes Pase André , Noll Gisele , Gomes da Fontoura Mariana , Dallegrave Letícia
Published: December 2020

This article aims to understand the transformations caused by new informational ecosystems in contemporary journalism. This analysis is performed based on news accessed through personal digital assistants embedded in smart speakers. As a methodological procedure, it adopts a multiple case study, defining the vocal transactors of Google (Nest Home/Google Assistant) and Amazon (Echo/Alexa) as its object. Therefore, this paper notes that the inclusion of algorithmic routines and the extension of news content to intelligent voice interfaces requires adaptation for the personalization of information, an ecosystem that is feedback by traditional vehicles, journalists, and people who interact with the artifacts.O presente artigo tem como objetivo compreender as transformações causadas por novos ecossistemas informacionais no jornalismo contemporâneo. Essa análise é realizada a partir de notícias acessadas através de assistentes pessoais digitais embarcados em alto-falantes inteligentes. Como procedimento metodológico, adota o estudo de caso múltiplo, definindo como objeto os transatores vocais da Google (Nest Home/Google Assistant) e da Amazon (Echo/Alexa). Observa, portanto, que a inclusão de rotinas algorítmicas e a extensão de conteúdo noticioso para interfaces de voz inteligentes demanda adaptação para a personalização das informações, ecossistema que é retroalimentado por veículos tradicionais, jornalistas e pessoas que interagem com os artefatos.Este artículo tiene como objetivo comprender las transformaciones causadas por los nuevos ecosistemas informativos en el periodismo contemporáneo. Este análisis se realiza en función de las noticias a las que se accede a través de asistentes digitales personales integrados en altavoces inteligentes. Como procedimiento metodológico, adopta un estudio de caso múltiple, definiendo los transactores vocales de Google (Nest Home/Google Assistant) y Amazon (Echo/Alexa) como su objeto. Señala, por lo tanto, que la inclusión de rutinas algorítmicas y la extensión del contenido de noticias a interfaces de voz inteligentes requiere adaptación para la personalización de la información, un ecosistema que es retroalimentado por vehículos tradicionales, periodistas y personas que interactúan con los artefactos.
Introduction: Journalism and algorithms
Authors: Lemos André , Domingo David
Published: December 2020

Making sense of the mutual shaping of journalism and algorithms requires research that closely analyses developments in very concrete, precise settings, but also studies that take a wider, theoretical perspective, or that put this evolution in historical context. This special issue provides this variety of points of view to contribute to the understanding of the opportunities and the challenges at the intersection between journalism and technology today.
Colloid cyst curtailed: A case report of spontaneous colloid cyst regression
Authors: Cosgrove Megan E. , Saadon Jordan , Chesler David A.
Published: December 2020

Background:

Colloid cysts arise from the roof of the third ventricle and are at risk for obstructing the flow of cerebrospinal fluid (CSF) and causing increased intracranial pressure. With advancements and increased frequency of imaging, colloid cysts are sometimes discovered incidentally. In these cases, the neurosurgeon is faced with the decision of whether to intervene or manage conservatively.

Case Description:

A 67-year-old man was discovered to have a colloid cyst when imaging was performed for transient neurologic deficits. CT and MRI brain revealed a 5mm lesion in the third ventricle with characteristics suggestive of the colloid cyst. Except for his initial presentation, the patient did not exhibit any symptoms and was followed with serial imaging. Four years after discovery, the colloid cyst regressed in size.

Conclusion:

The evolution and resolution of colloid cysts remain elusive; however, the discovery of incidental colloid cysts due to more frequent and more advanced neuroimaging emphasize the importance of this topic. The fear of conservative management is acute decompensation due to obstruction of CSF. However, surgical risks may be avoided if these asymptomatic lesions regress and resolve without intervention. Conservative management is a viable option for patients with colloid cysts, who may not only avoid surgery but who might also rarely experience cyst resolution.
Experimental assessment of major regulatory systems (adrenal, thyroid and gonadal) in liver metastases from s45 sarcoma
Authors: Каплиева И.В. , Франциянц Е.М. , Трепитаки Л.К. , Черярина Н.Д.
Published: December 2020

Метастазирование в печень - частый признак прогрессирования злокачественного процесса, механизм которого до конца не изучен. Цель - изучение особенностей функционирования основных систем нейрогуморальной регуляции: надпочечниковой (ГГНС), тиреоидной (ГГТС) и гонадной (ГГГС), на этапах метастазирования саркомы 45 (С45) в печень. Методика. Работа выполнена на 43 белых крысах-самцах. Через 1, 2, 5, 7 нед. от момента введения клеток саркомы 45 в дислоцированную под кожу селезенку. Органы взвешивались, в сыворотке крови (СК) методом РИА исследовали уровни фолликулостимулирующего гормона, лютеинизирующего гормона (ЛГ), тиреотропного гормона, адренокортикотропного гормона, кортизола, альдостерона, общей формы тестостерона, свободной и общей форм тироксина и трийодтиронина (Тсв и Т); методом ИФА - эстрона, эстрадиола, свободного тестостерона. Результаты. Метастазирование в печень сопровождалось активацией с последующим истощением ГГНС со снижением в 1,8 раза уровней кортизола и альдостерона в крови; значительной активацией ГГГС (пятикратное увеличение ЛГ в крови и уменьшение в 1,7 раза массы семенников) вследствие гипотестостеронемии (в 9,7 раза) на фоне гиперэстрадиолемии (в 2,3 раза); активацией ГГТС с формированием «low T» синдрома (в 4,6 раза). Заключение. Процесс метастазирования в печень - системная патология, в основе которой лежат глубокие нарушения работы основных систем регуляции организма.

Aim: To evaluate functioning of three major systems of neurohumoral regulation, adrenal (HPA), thyroid (HPT), and gonadal (HPG) axes, in liver metastasis based on weights of organs and blood levels of hormones. Methods: The study included 34 white male rats. Organs were weighted at 1, 2, 5, and 7 weeks after S45 sarcoma cell injections into the subcutaneously transferred spleen; blood serum levels of FSH, LH, TSH, ACTH, cortisol, aldosterone, total testosterone, free and total thyroxine, and triiodothyronine were measured by RIA; estrone, estradiol, and free testosterone concentrations were measured by ELISA. Results. The process of liver metastasis was accompanied by activation and following exhaustion of the HPA axis with 1.8 time decreases in blood levels of cortisol and aldosterone , significant activation of the HPG axis (5-fold increased LH level and 59% decreased testicular weight) due to hypotestosteronemia (9.7 times) and hyperestradiolemia (2.3 times), and activation of the HPT axis with the low T3 syndrome (4.6 times). Conclusion. Liver metastasis is a systemic pathology based on profound dysfunction of the major regulatory systems.