bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of Prognostic Hemodynamic Indices in Pulmonary Hypertension Using Non-Invasive Parameters
Authors: Mańczak Rafał , Kurzyna Marcin , Piłka Michał , Darocha Szymon , Florczyk Michał , Wieteska-Miłek Maria , Mańczak Małgorzata , Torbicki Adam
Published: August 2020

Effective targeted therapy of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH) requires regular risk stratification. Among many prognostic parameters, three hemodynamic indices: right atrial pressure, cardiac index, and mixed venous saturation are considered critically important for correct risk classification. All of them are measured invasively and require right heart catheterization (RHC). The study was aimed to verify assumption that a model based on non-invasive parameters is able to predict hemodynamic profile described by the mentioned invasive indices. A group of 330 patients with pulmonary hypertension was used for the selection of the best predictors from the set of 17 functional, biochemical, and echocardiographic parameters. Multivariable logistic regression models for the prediction of low-risk and high-risk profiles were created. The cut-off points were determined and subsequent validation of the models was conducted prospectively on another group of 136 patients. The ROC curve analysis showed the very good discrimination power of the models (AUC 0.80–0.99) in the prediction of the hemodynamic profile in the total validation group and subgroups: PAH and CTEPH. The models indicated the risk profiles with moderate sensitivity (57–60%) and high specificity (87–93%). The method enables estimation of the hemodynamic indices when RHC cannot be performed.
Innovating Higher Education via Game-Based Learning on Misconceptions
Authors: Belova Nadja , Zowada Christian
Published: August 2020

In recent years, serious games and game-based learning have received growing attention in educational contexts in general and science teaching and learning. They play an especially prominent role in higher education, where they are used to promote content knowledge as well as higher order cognitive skills and competencies such as communication, collaboration, or problem solving. Despite some known positive effects of serious games on learning, critical voices claim that the objectives of a specific game often do not match the learning objectives and that the games focus on entertaining much more than learning. Considering these arguments and some general guidelines of using games in (higher) education, we developed a game on typical chemical misconceptions based on the popular game “Activity©” using Participatory Action Research. The game was developed based on the contents of a seminar on misconceptions for pre-service teachers (M. Ed. students) in a northern German university. It covers seven content areas where misconceptions are most prevalent and therefore aims at contributing to pre-service teachers’ Pedagogical Content Knowledge (PCK). The students are supposed to draw or mime specific misconceptions. Initial trials in three university courses showed a very positive perception of the game.
Avoiding the Privacy Paradox Using Preference-Based Segmentation: A Conjoint Analysis Approach
Authors: Kuzmanovic Marija , Savic Gordana
Published: August 2020

Personal privacy on online social networks (OSN) is becoming increasingly important. The collection and misuse of personal information can affect people’s behavior and can have a broader impact on civil society. The aim of this paper is to explore the privacy paradox phenomenon on OSNs that is reflected in the gap between OSN users’ privacy concerns and behavior and to introduce a new segmentation framework based on preference data from conjoint analysis. For the purpose of the study, an online survey on four dimensions of OSNs has been conducted. Conjoint analysis has been employed on collected data to reveal users’ preferences, followed by two-step cluster analysis for the preference-based segmentation. The characteristics of the resulting clusters were compared with self-reported behavior and privacy concerns, as well as the results of the Westin Privacy Segmentation approach. The results suggest that conjoint analysis can improve users’ segmentation and consequently provide better solutions for avoiding the gap between users’ concerns, attitudes, and behavior.
Entire Magnetic Integration Method of Multi-Transformers and Resonant Inductors for CLTLC Resonant Converter
Authors: Liu Ruixin , Wang Yifeng , Chen Qing , Han Fuqiang , Meng Zhun
Published: August 2020

An entire magnetic integration methodology of high efficiency printed circuit board (PCB) winding transformer for CLTLC (capacitor-inductor-transformer-inductor-capacitor) resonant converter is presented. All magnetic components in the converter, including two resonant inductors and two transformers, are integrated into an improved EIE (E-type and I-type and E-type) core structure. According to the matrix transformer concept and uneven winding distribution, the novel structure can be obtained by introducing an air gap to the center core leg. Thus, the magnetizing inductance and leakage inductance of the transformer can be controlled easily through adjusting the air gap reluctances. In addition, both the detailed mathematical analysis and the reluctance model of the transformer have been studied. Furthermore, a four-layer printed circuit board winding structure is chosen. The related winding arrangement is also discussed in depth. Finally, a 1 kW prototype with the presented structure is implemented to verify the validity of the theoretical analysis. Experimental results demonstrate that the proposed structure guarantees high efficiency within the entire load range. Peak efficiency of 96.62% can be ensured.
Numerical Study on the Working Performance of a Streamlined Annular Jet Pump
Authors: Wang Xiaodong , Chen Yunliang , Li Mengqiu , Xu Yong , Wang Bo , Dang Xiaoqiang
Published: August 2020

To improve the working performance of the early annular jet pump (EAJP), a streamlined annular jet pump (SAJP) was proposed. The flow field and working performance of the EAJP and SAJP with an area ratio (m) of 1.75 were numerically studied and compared, separately, by using the combination of the Realizable k-ε turbulence model and the Schnerr–Sauer cavitation model. The results show that the efficiency of the SAJP is higher than that of the EAJP, when the flow ratio (q) is higher than 0.30, with a maximum increase of 1.2%. Furthermore, the high-efficiency area of the SAJP (q = 0.40~0.69) is wider than that of the EAJP (q = 0.36~0.57). There is no flow separation and low local pressure in the SAJP, due to the conjunction part of the suction chamber, throat, diffuser and outlet pipe without the structural mutation. It was found that the incipient cavitation number (σi) of the SAJP and EAJP was 0.541 and 0.578, respectively; therefore, the cavitation performance of the SAJP is better. Meanwhile, the critical flow ratio (qc) of the SAJP is 0.69, which is larger than that of the EAJP (qc = 0.57), implying that the SAJP has a wider normal working range than the EAJP. Importantly, the inception and development of cavitation appeared in the diffuser of the SAJP, different from that in the throat of the EAJP. Hence, it concluded that the cavitation in the SAJP has less influence on the flow field and working performance.
Multidisciplinary Characterization of Unconventional Reservoirs Based on Correlation of Well and Seismic Data
Authors: Kaczmarczyk Weronika , Słota-Valim Małgorzata
Published: August 2020

Combinatorial analysis of key petrophysical parameters can provide valuable information about subsurface hydrocarbon reservoirs. This is particularly important for reservoirs with unconventional rock formations that, due to the low permeability, need to be stimulated by fracturing treatment to provide fluid flow to the exploitation wellbore. In this article, based on data from unconventional shale formations (N Poland), we outline how independent sets of elastic and petrophysical parameters and other reservoir features can be co-analyzed to estimate the fracture susceptibility of shale intervals, which are characterized by a high total organic carbon (TOC) content and high porosity. These features were determined by analysis of each horizon’s elastic and mineralogical brittleness index (BI). These two variants were calculated first in 1D; integrated with the seismic data and finally compared with other parameters such as acoustic impedance, ratio of compressional and shear wave velocities, porosity, and density; and then presented and analyzed using cross plots that highlighted the key relationships between them. The overall BI trends were similar in both horizontal and vertical directions. The highest BI values were observed in the southeast of the analyzed area (Source I) and in the southeast and northwest of the area (Source II). These results can form the basis for predictive modeling of reservoir properties aiding effective reservoir exploration.
Sewage Sludge Valorization via Hydrothermal Carbonization: Optimizing Dewaterability and Phosphorus Release
Authors: Lühmann Taina , Wirth Benjamin
Published: August 2020

As the use of sewage sludge as a fertilizer in agriculture is increasingly restricted in the European Union, other ways to utilize this waste stream need to be developed. Sewage sludge is an ideal input material for the process of hydrothermal carbonization, as it can convert wet biomass into a solid energy carrier with increased mechanical dewaterability. Digested sewage sludge was hydrothermally carbonized at 160–200 °C for 30–60 min with initial pH levels of 1.93–8.08 to determine optimal reaction conditions for enhanced dewaterability and phosphorus release into the liquid phase. Design of experiments was used to develop response surface models, which can be applied to optimize the process conditions. For optimal dewaterability and phosphorus release, low initial pH values (pH 1.93) and mild temperatures around 170 °C are favorable. Because holding time had no statistically relevant effect, a dependency of reaction time was investigated. Though it did not yield substantially different results, it could be included in investigations of short reaction times prospectively. Low reaction temperatures and short holding times are desirable considering economic reasons for scale-up, while the high acid consumption necessary to achieve these results is unfavorable.
Adjustment of the Life Cycle Inventory in Life Cycle Assessment for the Flexible Integration into Energy Systems Analysis
Authors: Betten Thomas , Shammugam Shivenes , Graf Roberta
Published: August 2020

With an increasing share of renewable energy technologies in our energy systems, the integration of not only direct emission (from the use phase), but also the total life cycle emissions (including emissions during resource extraction, production, etc.) becomes more important in order to draw meaningful conclusions from Energy Systems Analysis (ESA). While the benefit of integrating Life Cycle Assessment (LCA) into ESA is acknowledged, methodologically sound integration lacks resonance in practice, partly because the dimension of the implications is not yet fully understood. This study proposes an easy-to-implement procedure for the integration of LCA results in ESA based on existing theoretical approaches. The need for a methodologically sound integration, including the avoidance of double counting of emissions, is demonstrated on the use case of Passivated Emitter and Rear Cell photovoltaic technology. The difference in Global Warming Potential of 19% between direct and LCA based emissions shows the significance for the integration of the total emissions into energy systems analysis and the potential double counting of 75% of the life cycle emissions for the use case supports the need for avoidance of double counting.
A Mixed-Integer Nonlinear Programming Model for Optimal Reconfiguration of DC Distribution Feeders
Authors: Montoya O. D. , Gil-González W. , Hernández J. C. , Giral-Ramírez D. A. , Medina-Quesada A.
Published: August 2020

This paper deals with the optimal reconfiguration problem of DC distribution networks by proposing a new mixed-integer nonlinear programming (MINLP) formulation. This MINLP model focuses on minimising the power losses in the distribution lines by reformulating the classical power balance equations through a branch-to-node incidence matrix. The general algebraic modelling system (GAMS) is chosen as a solution tool, showing in tutorial form the implementation of the proposed MINLP model in a 6-nodes test feeder with 10 candidate lines. The validation of the MINLP formulation is performed in two classical 10-nodes DC test feeders. These are typically used for power flow and optimal power flow analyses. Numerical results demonstrate that power losses are reduced by about 16% when the optimal reconfiguration plan is found. The numerical validations are made in the GAMS software licensed by Universidad Tecnológica de Bolívar.
Particle-Scale Simulation of Solid Mixing Characteristics of Binary Particles in a Bubbling Fluidized Bed
Authors: Lin Junjie , Luo Kun , Wang Shuai , Sun Liyan , Fan Jianren
Published: August 2020

The behavior of solid mixing dynamic is of profound significance to the heat transfer and reaction efficiencies in energy engineering. In the current study, the solid mixing characteristics of binary particles in the bubbling fluidized bed are further revealed at particle-scale. Specifically, the influences of gas superficial velocity, Sauter mean diameter (SMD) in the system and the range distribution of particle sizes on the performance of mixing index are quantitatively explored using a computational fluid dynamics-discrete element method (CFD-DEM) coupling model. The competition between solid segregation and the mixing of binary particles is deeply analyzed. There is a critical superficial velocity that maximizes the mixing index of the binary mixture in the bubbling fluidized bed. Solid mixing performs more aggressive when below the critical velocity, otherwise solid segregation overtakes mixing when above this critical velocity. Moreover, superficial velocity is a major factor affecting the mixing efficiency in the binary bubbling fluidized bed. Additionally, the mixing behavior is enhanced with the decrease of SMD while it is deteriorated in the binary system with a wide range of particle size distribution. Therefore, it is highly recommended to perform a binary particle system with smaller SMD and closer particle size distribution for the purpose of enhancing the mixing behavior. The significant understanding of mixing characteristics is expected to provide valuable references for the design, operation, and scale-up of binary bubbling fluidized bed.
Investigating the Optimal Location of Potential Forest Industry Clusters to Enhance Domestic Timber Utilization in South Korea
Authors: Woo Heesung , Han Hee , Cho Seungwan , Jung Geonhwi , Kim Bomi , Ryu Jiyeon , Won Hyun Kyu , Park Joowon
Published: August 2020

South Korea has abundant forest resources capable of supplying the domestic wood demand. Despite the extensive forest resources, there is continued uncertainty about the nature, quantity, and quality of the timber contained in any particular forested area. Additionally, some technical, logistic, and economic challenges act as barriers to the expansion of domestic timber utilization. To overcome these limitations and to enhance the domestic timber utilization in South Korea, this study investigated the optimal location of potential forest industry clusters. The potential forest availability was estimated based on localized allometric equations. The integration of the analytical hierarchy process and GIS modeling, including a supply chain that minimizes transportation costs, allowed the identification of optimal forest industry clusters locations that balanced the economic, environmental, and social dimensions within the forest industry supply chain. The study reveals that the estimated potential forest resources availability presented approximately 1 billion m3, including sawlog (474 million m3) and pulpwood grade (541 million m3). Additionally, 45 percent of the sawlogs and 48 percent of the pup grade wood were produced from the Gangwon and Gyeongsangbuk-do regions. Furthermore, the logistic analysis indicates that ten potential forest industry clusters are best aligned with the optimal socio-economic impacts with minimized timber transportation costs. To identify the optimal size and number of potential forest industry clusters, further studies that consider fixed and variable costs for maintaining the forest industry clusters are required.
Performance of Five Native Atlantic Forest Species Planted in Containers of Different Size for Restoring Degraded Areas in Minas Gerais
Authors: Junior Vicente Toledo Machado de Morais , Jacovine Laércio Antônio Gonçalves , Oliveira Klisman , Albuquerque Thaynara Pereira , Faustino Isabella Salgado , Silva Lauana Blenda , Alves Eliana Boaventura Bernardes Moura , Torres Carlos Moreira Miquelino Eleto , de Paiva Haroldo Nogueira , Cruz Ricardo Alcántara-de la
Published: August 2020

Forest restoration in Brazil has gained relevance in the country’s environmental agenda, due to the need for forest recovery of large liabilities of existing forests and participation in several international vegetation restoration agreements. However, forest restoration management faces challenges, it being necessary to create a database of species-level performances to increase the success of these projects. The objective was to evaluate the survival and growth of five Atlantic Forest native species (Anadenanthera macrocarpa; Ceiba speciosa; Cytharexyllum myrianthum; Hymenaea courbaril; and Peltophorum dubium) in plastic bags (1177 cm3) and tubes (180 cm3). Ninety seedlings (18 of each species) were planted per container. Plant performance in the field consisted of evaluating the increase in the diameter and height of seedlings of the native forest species. Diameter at soil level (DSL) and plant height (H) were measured at 42 months after transplanting, and the monthly periodic increments (MPI) of the DSL and H were calculated. Plant survival (SV) of seedlings was affected by the type of container, registering the highest SV rates in those planted in plastic bags. Cytharexyllum myrianthum and H. courbaril presented high SV rates in tubes. The growth rate of the species at 42 months differed according to the containers tested. Cytharexyllum myrianthum presented the lowest SV rates (16.7–27.8%), regardless of the container used in this experiment. Ceiba speciosa was sensitive to the reduction in size of the container, showing low SV in tubes (27%) compared with plastic bags (61%); i.e., this species did not tolerate conditions with root growth restriction. Anadenathera macrocarpa and H. courbaril showed no differences in SV, regardless of the container used. The results assist the production of native species of the Atlantic Forest, reinforcing the need to understand performances in the field at the species level.
Forest Landscape Restoration—What Generates Failure and Success?
Authors: Höhl Markus , Ahimbisibwe Vianny , Stanturf John A. , Elsasser Peter , Kleine Michael , Bolte Andreas
Published: August 2020

Research Highlights: The global Forest Landscape Restoration ambitions could be impaired by projects that ignore key principles such as the engagement of local communities in decision making and implementation, equitable benefit sharing, and monitoring for adaptive management. This entails the danger of continued degradation, disappointed local stakeholders, and ultimately, project failure. Other projects face technical problems related to tree establishment and nursery production. Background and Objectives: There are high hopes for Forest and Landscape Restoration to regain ecosystem integrity and enhance human well-being in deforested and degraded areas. We highlight various problems and success factors experienced during project implementation on a global scale. Materials and Methods: We use data from a global online survey to identify common obstacles and success factors for the implementation of forest restoration. Results: While the majority of respondents reported successful projects, others indicate drastic problems and failed projects. Major obstacles to forest restoration experienced by survey respondents were a lack of local stakeholder involvement and a mismatch between goals of local communities and restoration managers, as well as environmental, anthropogenic, and technical barriers to tree regeneration. Conclusions: When local communities, their goals, and needs are disregarded in project planning and implementation, as reported from various cases in our survey and the limited available literature, there is a risk of project failure. Failed projects and disappointed stakeholders, as well as discouraged funders and policy-makers, could lessen the momentum of global forest restoration ambitions. Adhering to key principles of Forest and Landscape Restoration can promote much-needed community support, with the potential to overcome barriers to forest regeneration and enable communities for the protection, management, and monitoring of the restored forests beyond the limited project and funding periods. Research is needed to gain a better understanding of the perception of local communities towards restoration activities. Further studies on the implementation of forest restoration at the intersection of environmental factors, socioeconomic conditions, forest regeneration/silviculture, and nursery production are needed.
The Propagation of Nonlinear Internal Waves under the Influence of Variable Topography and Earth’s Rotation in a Two-Layer Fluid
Authors: Nik Ismail Nik Nur Amiza , Alias Azwani , Harun Fatimah N.
Published: August 2020

A nonlinear equation of the Korteweg–de Vries equation usually describes internal solitary waves in the coastal ocean that lead to an exact solitary wave solution. However, in any real application, there exists the Earth’s rotation. Thus, an additional term is required, and consequently, the Ostrovsky equation is developed. This additional term is believed to destroy the solitary wave solution and form a nonlinear envelope wave packet instead. In addition, an internal solitary wave is commonly disseminated over the variable topography in the ocean. Because of these effects, the Ostrovsky equation is retrieved by a variable-coefficient Ostrovsky equation. In this study, the combined effects of both background rotation and variable topography on a solitary wave in a two-layer fluid is studied since internal waves typically happen here. A numerical simulation for the variable-coefficient Ostrovsky equation with a variable topography is presented. Two basic examples of the depth profile are considered in detail and sustained by numerical results. The first one is the constant-slope bottom, and the second one is the specific bottom profile following the previous studies. These indicate that the combination of variable topography and rotation induces a secondary trailing wave packet.
Reading Storylines of Religious Motherhood with Ethics of Joy
Authors: Rantala Teija
Published: August 2020

In this article the storylines of a religious mother are read with Rosi Braidotti’s formulation of joyful and affirmative ethics. This ethics sets these storylines in motion and illuminates the changes that occur concerning devotion, resistance, and resilience in the face of the expectations of religious motherhood. This diffractive reading makes explicit the changing affects functioning in non-normative narratives and the compound and polyvocal ethics of becoming concerning (religious) motherhood, reproduction, and sustenance in these troubling times—times which compel us to live within compassionate ethics. The ethics of joy brings forward affective elements by allowing also the negative affects entangled in pain and trauma to be recognised as resistance. Besides assisting in reading the storylines for possible breaks, turns, and changes, diffractive reading makes often-neglected tacit elements matter. The forces fuelling the movement in the storylines bring forth equally symmetries, disparities, and changes, and the complex but also complementary relation of resilience and resistance as a part of feminist genealogies of affect.
Leigh Syndrome in a Pedigree Harboring the m.1555A>G Mutation in the Mitochondrial 12S rRNA
Authors: Habbane Mouna , Llobet Laura , Bayona-Bafaluy M. Pilar , Bárcena José E. , Ceberio Leticia , Gómez-Díaz Covadonga , Gort Laura , Artuch Rafael , Montoya Julio , Ruiz-Pesini Eduardo
Published: August 2020

Background: Leigh syndrome (LS) is a serious genetic disease that can be caused by mutations in dozens of different genes. Methods: Clinical study of a deafness pedigree in which some members developed LS. Cellular, biochemical and molecular genetic analyses of patients’ tissues and cybrid cell lines were performed. Results: mitochondrial DNA (mtDNA) m.1555A>G/MT-RNR1 and m.9541T>C/MT-CO3 mutations were found. The first one is a well-known pathologic mutation. However, the second one does not appear to contribute to the high hearing loss penetrance and LS phenotype observed in this family. Conclusion: The m.1555A>G pathological mutation, accompanied with an unknown nuclear DNA (nDNA) factor, could be the cause of the phenotypic manifestations in this pedigree.
Deciphering the Forebrain Disorder in a Chicken Model of Cerebral Hernia
Authors: Tao Yingfeng , Zhou Xiaoliu , Zheng Xinting , Li Shijun , Mou Chunyan
Published: August 2020

Cerebral hernia in crested chicken has been characterized as the protrusion of cerebral hemispheres into the unsealed skull for hundreds of years, since Charles Darwin. The development of deformed forebrain (telencephalon) of cerebral hernia remains largely unknown. Here, the unsealed frontal skull combined with misplaced sphenoid bone was observed and potentially associated with brain protuberance. The shifted pallidum, elongated hippocampus, expanded mesopallium and nidopallium, and reduced hyperpallium were observed in seven regions of the malformed telencephalon. The neurons were detected with nuclear pyknosis and decreased density. Astrocytes showed uneven distribution and disordered protuberances in hyperpallium and hippocampus. Transcriptome analyses of chicken telencephalon (cerebral hernia vs. control) revealed 547 differentially expressed genes (DEGs), mainly related to nervous system development, and immune system processes, including astrocyte marker gene GFAP, and neuron and astrocyte developmental gene S100A6. The upregulation of GFAP and S100A6 genes in abnormal telencephalon was correlated with reduced DNA methylation levels in the promoter regions. The morphological, cellular, and molecular variations in the shape, regional specification, and cellular states of malformed telencephalon potentially participate in brain plasticity and previously reported behavior changes. Chickens with cerebral hernia might be an interesting and valuable disease model to further explore the recognition, diagnosis, and therapy of cerebral hernia development of crested chickens and other species.
Special Issue: Animal Modeling in Cancer
Authors: Korinek Vladimir
Published: August 2020

Recent advances in high-throughput sequencing techniques have significantly accelerated the development of personalized diagnostic tools and cancer treatments. However, a comparative analysis of experimental animals that share similar genetic, physiological, and behavioral traits with humans remains the basis for understanding the pathological mechanisms associated with human diseases, including cancer. The generation and characterization of suitable animal models mimicking tumor growth and progression thus represents an important “component” of tumor biology research. The presented Special Issue contains ten review articles, which, based on data obtained from various animal models, summarize a number of aspects of the tumor formation process that include gastrointestinal neoplasia, breast cancer, hematological malignancies, melanoma, and brain tumors. This Special Issue nicely illustrates how the study of suitable living models uncovers not only the fundamental molecular and cellular bases of neoplastic growth, but might also indicate approaches to efficient cancer treatments.
COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells
Authors: Latini Andrea , Agolini Emanuele , Novelli Antonio , Borgiani Paola , Giannini Rosalinda , Gravina Paolo , Smarrazzo Andrea , Dauri Mario , Andreoni Massimo , Rogliani Paola , Bernardini Sergio , Helmer-Citterich Manuela , Biancolella Michela , Novelli Giuseppe
Published: August 2020

The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene, we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID-19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS-CoV-2. These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity.
Relationship between Clinical Parameters and Chromosomal Microarray Data in Infants with Developmental Delay
Authors: Lee Zeeihn , Lee Byung Joo , Park Sungwon , Park Donghwi
Published: August 2020

Chromosomal microarray (CMA) is considered a first-tier test for genetic analysis as it can be used to examine gene copy number variations (CNVs) throughout the entire genome, with enhanced sensitivity for detecting submicroscopic deletions and duplications. However, its cost can represent a heavy burden. Moreover, the diagnostic yield of CMA in infants with developmental delay (DD) was reported to be less than 10%. Therefore, we aimed to investigate the relationship between CMA results and clinical features and risk factors of DD. The study included 59 infants with DD who were recruited between August 2019 and February 2020 during a visit to the outpatient clinic of a rehabilitation department. We reviewed the clinical records of the infants regarding gender, age, body weight at birth, delivery method, brain imaging data, perinatal history, and parent-related clinical parameters, such as mother and father age at birth. The infants were categorized according to CMA results, and differences in clinical parameters were evaluated. Except for brain anomalies, there was no statistically significant differences between infants who had pathogenic and variants of unknown significance (VOUS)-likely pathogenic CNVs groups compared with those within the VOUS-likely no sub-classification, VOUS-likely benign, benign, and normal CNVs groups. The incidence of brain anomalies was significantly higher within infants with pathogenic and VOUS-likely pathogenic CNVs groups (p < 0.05). Our study suggests that infants with DD who present dysmorphism or brain anomaly may benefit from early CMA analysis, for adequate diagnosis and timely treatment. Further studies are warranted to confirm the relationship between DD clinical parameters and CMA results.
Air Quality Change in Seoul, South Korea under COVID-19 Social Distancing: Focusing on PM2.5
Authors: Han Beom-Soon , Park Kyeongjoo , Kwak Kyung-Hwan , Park Seung-Bu , Jin Han-Gyul , Moon Sungju , Kim Jong-Won , Baik Jong-Jin
Published: August 2020

Seoul, the most populous city in South Korea, has been practicing social distancing to slow down the spread of coronavirus disease 2019 (COVID-19). Fine particulate matter (PM2.5) and other air pollutants measured in Seoul over the two 30 day periods before and after the start of social distancing are analyzed to assess the change in air quality during the period of social distancing. The 30 day mean PM2.5 concentration decreased by 10.4% in 2020, which is contrasted with an average increase of 23.7% over the corresponding periods in the previous 5 years. The PM2.5 concentration decrease was city-wide and more prominent during daytime than at nighttime. The concentrations of carbon monoxide (CO) and nitrogen dioxide (NO2) decreased by 16.9% and 16.4%, respectively. These results show that social distancing, a weaker forcing toward reduced human activity than a strict lockdown, can help lower pollutant emissions. At the same time, synoptic conditions and the decrease in aerosol optical depth over the regions to the west of Seoul support that the change in Seoul’s air quality during the COVID-19 social distancing can be interpreted as having been affected by reductions in the long-range transport of air pollutants as well as local emission reductions.
Topic Modeling for Analyzing Patients’ Perceptions and Concerns of Hearing Loss on Social Q&A Sites: Incorporating Patients’ Perspective
Authors: Bahng Junghwa , Lee Chang Heon
Published: August 2020

Hearing loss is the most common human sensory deficit, affecting normal communication. Recently, patients with hearing loss or at risk of hearing loss are increasingly turning to the online health community for health information and support. Information on health-related topics exchanged on the Internet is a useful resource to examine patients’ informational needs. The ability to understand the patients’ perspectives on hearing loss is critical for health professionals to develop a patient-centered intervention. In this paper, we apply Latent Dirichlet Allocation (LDA) on electronic patient-authored questions on social question-and-answer (Q&A) sites to identify patients’ perceptions, concerns, and needs on hearing loss. Our results reveal 21 topics, which are both representative and meaningful, and mostly correspond to sub-fields established in hearing science research. The latent topics are classified into five themes, which include “sudden hearing loss”, “tinnitus”, “noise-induced hearing loss”, “hearing aids”, “dizziness”, “curiosity about hearing loss”, “otitis media” and “complications of disease”. Our topic analysis of patients’ questions on the topic of hearing loss allows achieving a thorough understanding of patients’ perspectives, thereby leading to better development of the patient-centered intervention.
Workaholism, Work Engagement and Child Well-Being: A Test of the Spillover-Crossover Model
Authors: Shimazu Akihito , Bakker Arnold B. , Demerouti Evangelia , Fujiwara Takeo , Iwata Noboru , Shimada Kyoko , Takahashi Masaya , Tokita Masahito , Watai Izumi , Kawakami Norito
Published: August 2020

This study examines how working parents’ work attitudes (i.e., workaholism and work engagement) are associated with their child’s psychological well-being. Based on the Spillover-Crossover model (SCM), we hypothesize that (a) work-to-family spillover (i.e., work-to-family conflict and facilitation) and (b) employee happiness will sequentially mediate the relationship between parents’ work attitudes and their child’s emotional and behavioral problems. A cross-sectional survey was conducted among Japanese dual-earner couples with pre-school child(ren). On the basis of valid data from 208 families, the hypothesized model was tested using structural equation modeling. For both fathers and mothers simultaneously, workaholism was positively related to work-to-family conflict, which, in turn, was negatively related to happiness. In contrast, work engagement was positively related to work-to-family facilitation, which, in turn, was positively related to happiness. Fathers’ and mothers’ happiness, in turn, were negatively related to their child’s emotional and behavioral problems. Results suggest that parents’ workaholism and work engagement are related to their child’s emotional and behavioral problems in opposite ways, whereby parents’ spillover and happiness mediate this relationship. These findings support the SCM and suggest that decreasing workaholism and improving work engagement may not only improve employees’ happiness, but also decrease their child’s emotional and behavioral problems.
Associations between 24 h Movement Behavior and Mental Health in Office Workers
Authors: Larisch Lisa-Marie , Kallings Lena V. , Hagströmer Maria , Desai Manisha , von Rosen Philip , Blom Victoria
Published: August 2020

The associations between 24 h movement behavior, i.e., the way people distribute their time in different movement-related behaviors, on mental health are not well understood. This study applied a compositional data analysis approach to explore cross-sectional associations between device-measured moderate to vigorous physical activity (MVPA), light intensity physical activity (LIPA), sedentary behavior (SED), self-reported time in bed and mental health outcomes, i.e., depression or anxiety symptoms, burnout, mental wellbeing and stress, in office workers. ActiGraph accelerometers were worn for 24 h for at least 4 days to assess MVPA, LIPA, and SED. Sleep diaries were used in addition to identify time in bed. Analytic sample sizes for the different outcomes ranged from N = 345–370 participants. In this population of office workers with high levels of MVPA, the entire movement behavior composition was not associated to any of the mental health outcomes, but MVPA relative to all other behaviors was positively associated with mental wellbeing. This confirms the importance of MVPA for health relative to other movement-related behaviors.
“When I Breastfeed, It Feels as if my Soul Leaves the Body”: Maternal Capabilities for Healthy Child Growth in Rural Southeastern Tanzania
Authors: Mchome Zaina , Yousefzadeh Sepideh , Bailey Ajay , Haisma Hinke
Published: August 2020

The burden of childhood stunting in Tanzania is persistently high, even in high food-producing regions. This calls for a paradigm shift in Child Growth Monitoring (CGM) to a multi-dimensional approach that also includes the contextual information of an individual child and her/his caregivers. To contribute to the further development of CGM to reflect local contexts, we engaged the Capability Framework for Child Growth (CFCG) to identify maternal capabilities for ensuring healthy child growth. Ethnographic fieldwork was conducted in Southeastern Tanzania using in-depth interviews, key informant interviews, participant observation, and focus group discussions with caregivers for under-fives. Three maternal capabilities for healthy child growth emerged: (1) being able to feed children, (2) being able to control and make decisions on farm products and income, and (3) being able to ensure access to medical care. Mothers’ capability to feed children was challenged by being overburdened by farm and domestic work, and gendered patterns in childcare. Patriarchal cultural norms restricted women’s control of farm products and decision-making on household purchases. The CFCG could give direction to the paradigm shift needed for child growth monitoring, as it goes beyond biometric measures, and considers mothers’ real opportunities for achieving healthy child growth.
Physical Fitness, Selective Attention and Academic Performance in a Pre-Adolescent Sample
Authors: Páez-Maldonado José A. , Reigal Rafael E. , Morillo-Baro Juan P. , Carrasco-Beltrán Hernaldo , Hernández-Mendo Antonio , Morales-Sánchez Verónica
Published: August 2020

The purpose of the current study is to analyze the relationships between physical fitness, selective attention, and academic performance in pre-teens. The sample here consists of 135 participants between the ages of 10 and 12 (M = 11.05; SD = 0.61), with 39.26% female (n = 53) and 60.74% male (n = 82) participants. Horizontal and vertical jump distances, speed, and cardio-respiratory fitness were evaluated to assess physical fitness. The d2 Test of Attention was used to evaluate selective attention. In addition, data were obtained regarding participant academic performance by analyzing the academic performance. The results show significant relationships between the measures analyzed, highlighting positive associations between physical fitness, cognitive functioning, and academic performance. Thus, participants who were fitter scored better on tests of attention (Z133 = −4.07; p < 0.00007, Cohen’s d = 0.75, 95% CI (0.39, 1.11)) and concentration (t133 = −3.84; p < 0.0007, Cohen’s d = 0.69, 95% CI (0.33, 1.05)), as well as having higher academic performance (Z133 = −2.84; p < 0.0035, Cohen’s d = 0.39, 95% CI (0.04, 0.75)). Cardiorespiratory fitness was the measure of physical fitness that best explained these relationships. The results suggest that maintaining and improving the physical fitness of children and adolescents may help their brain function develop better.
The Prediction of Infectious Diseases: A Bibliometric Analysis
Authors: Yang Wenting , Zhang Jiantong , Ma Ruolin
Published: August 2020

Objective: The outbreak of infectious diseases has a negative influence on public health and the economy. The prediction of infectious diseases can effectively control large-scale outbreaks and reduce transmission of epidemics in rapid response to serious public health events. Therefore, experts and scholars are increasingly concerned with the prediction of infectious diseases. However, a knowledge mapping analysis of literature regarding the prediction of infectious diseases using rigorous bibliometric tools, which are supposed to offer further knowledge structure and distribution, has been conducted infrequently. Therefore, we implement a bibliometric analysis about the prediction of infectious diseases to objectively analyze the current status and research hotspots, in order to provide a reference for related researchers. Methods: We viewed “infectious disease*” and “prediction” or “forecasting” as search theme in the core collection of Web of Science from inception to 1 May 2020. We used two effective bibliometric tools, i.e., CiteSpace (Drexel University, Philadelphia, PA, USA) and VOSviewer (Leiden University, Leiden, The Netherlands) to objectively analyze the data of the prediction of infectious disease domain based on related publications, which can be downloaded from the core collection of Web of Science. Then, the leading publications of the prediction of infectious diseases were identified to detect the historical progress based on collaboration analysis, co-citation analysis, and co-occurrence analysis. Results: 1880 documents that met the inclusion criteria were extracted from Web of Science in this study. The number of documents exhibited a growing trend, which can be expressed an increasing number of experts and scholars paying attention to the field year by year. These publications were published in 427 different journals with 11 different document types, and the most frequently studied types were articles 1618 (83%). In addition, as the most productive country, the United States has provided a lot of scientific research achievements in the field of infectious diseases. Conclusion: Our study provides a systematic and objective view of the field, which can be useful for readers to evaluate the characteristics of publications involving the prediction of infectious diseases and for policymakers to take timely scientific responses.
The 4 U’s Rule of Fibromyalgia: A Proposed Model for Fatigue in a Sample of Women with Fibromyalgia: A Qualitative Study
Authors: Velasco-Furlong Lilian , Gutiérrez-Hermoso Lorena , Mateos-Pintado Beatriz , Castro Daniel Garvi-de , Blanco-Rico Sheila , Sanromán-Canelada Lucía , López-Roig Sofía , Pastor-Mira María Ángeles , Peñacoba-Puente Cecilia
Published: August 2020

Although fatigue usually goes unnoticed, it is a symptom that poses great challenges to patients with fibromyalgia and is a strong limitation. The aim of this study is to identify and describe the variables involved in fatigue in nine different situations of the Goal Pursuit Questionnaire (GPQ) that may occur in the daily lives of women with fibromyalgia, according to an ABC (Antecedents–Behaviors–Consequences) model. This study followed a qualitative descriptive research method and a deductive–inductive hybrid approach based on a phenomenological paradigm. Twenty-six women with fibromyalgia participated in focus group discussions between February and March of 2018. Thematic content analysis was carried out from transcribed verbatim interviews. We identified nine major themes that emerged from the participants’ conversations: self-imposed duties, muscle fatigue, overwhelming feeling of tiredness, difficulty thinking, difficulty concentrating, negative emotions, lifestyle changes, affected everyday activities, and lack of motivation for daily activities and social interactions. We conclude that the ABC model allowed certain elements to emerge regarding the fatigue experience, highlighting its importance as a symptom in fibromyalgia. This additional analysis of the ABC model showed that fatigue can be described through the 4 U’s Rule, which is integrated by these four adjectives: (1) Unpredictable, (2) Uncontrollable, (3) Unseen, and (4) Unintelligible. Identifying these characteristics can contribute to a better understanding of fibromyalgia in addition to better treatment for these patients.
Maximal Oxygen Uptake Adjusted for Skeletal Muscle Mass in Competitive Speed-Power and Endurance Male Athletes: Changes in a One-Year Training Cycle
Authors: Trinschek Jacek , Zieliński Jacek , Kusy Krzysztof
Published: August 2020

We compared the changes in maximum oxygen uptake (V·O2max) calculated per skeletal muscle mass (SMM) with conventional V·O2max measures in a 1-year training cycle. We hypothesized that the pattern of changes would differ between SMM-adjusted and absolute or weight-adjusted values, and the differences between groups of distinct training specialization and status will depend on the measure used. Twelve sprinters (24.7 ± 3.3 years), 10 endurance runners (25.3 ± 5.3 years), and 10 recreationally trained controls (29 ± 4.5 years) performed a treadmill test until exhaustion to determine V·O2max. Their SMM was estimated based on the dual X-ray absorptiometry method and a regression equation. The significance of differences was assessed using analysis of variance (p ≤ 0.05). The pattern of the longitudinal change was not different between V·O2max/SMM and standard measures. Also, the significance of differences between sprinters and endurance athletes remained similar regardless of the V·O2max measure. Sprinters and controls had similar absolute (~4.3 L·min−1) and total weight-adjusted (~52 vs. ~56 mL·min−1·kg) V·O2max, but they significantly differed in SMM-adjusted V·O2max (~110 vs. ~130 mL·min−1·kg SMM−1). In summary, SMM-adjusted V·O2max is not more useful than standard measures to track longitudinal changes in competitive athletes. However, it allows to better distinguish between groups or individuals differing in training status. The results of our study are limited to male athletes.