bluuebunny/crossref_metadata_2025 huggingface dataset:
Association Between Cardiovascular Health and Cognitive Performance: A Twins Study
Authors: Kulshreshtha Ambar , Goetz Margarethe , Alonso Alvaro , Shah Amit J. , Bremner J. Douglas , Goldberg Jack , Vaccarino Viola
Published: August 2019

Background/Objective:

The 2020 Strategic Impact Goal introduced by the American Heart Association (AHA) aims at improving cardiovascular health (CVH) of all Americans by 20%. AHA defined ideal CVH across seven established modifiable risk factors for cardiovascular diseases. Prior studies have indicated that ideal CVH also benefits brain health and cognitive aging, but it is possible that this association is explained by familial factors.

Methods:

We examined 272 male monozygotic and dizygotic twin pairs (total 544 subjects) free of overt cardiovascular disease and dementia from the Vietnam Era Twin Registry. Memory and learning were measured by Trail Making tests and Wechsler Memory Scale (Immediate and Delayed Memory tests and Visual Reproductive Test). Each of the seven CVH components (smoking, body mass index, physical activity, diet, total cholesterol, blood pressure, and blood glucose) was scored per established criterion.

Results:

The mean age of the twins was 55 years, 96% were whites, and 61% monozygotic. When considering twins as individuals, for every unit increase in CVH score (indicating better cardiovascular health), twins demonstrated faster cognitive processing speed (Trail B: – 5.6 s, 95% CI – 10.3, – 0.9; p = 0.03) and better story recall, both immediate (0.35, 95% CI 0.06, 0.62; p = 0.02) and delayed (0.39, 95% CI 0.08, 0.70; p = 0.01).

Conclusions:

Better CVH is associated with better cognitive health in several domains. As suggested by within-pair analysis, this association is largely explained by familial factors, implying that early life exposures are shared determinants of both brain health and cardiovascular health.
Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions
Authors: Elmaleh David R. , Farlow Martin R. , Conti Peter S. , Tompkins Ronald G. , Kundakovic Ljiljana , Tanzi Rudolph E.
Published: August 2019

Alzheimer’s disease (AD) clinical trials, focused on disease modifying drugs and conducted in patients with mild to moderate AD, as well as prodromal (early) AD, have failed to reach efficacy endpoints in improving cognitive function in most cases to date or have been terminated due to adverse events. Drugs that have reached clinical stage were reviewed using web resources (such as clinicaltrials.gov, alzforum.org, company press releases, and peer reviewed literature) to identify late stage (Phase II and Phase III) efficacy clinical trials and summarize reasons for their failure. For each drug, only the latest clinical trials and ongoing trials that aimed at improving cognitive function were included in the analysis. Here we highlight the potential reasons that have hindered clinical success, including clinical trial design and choice of outcome measures, heterogeneity of patient populations, difficulties in diagnosing and staging the disease, drug design, mechanism of action, and toxicity related to the long-term use. We review and suggest approaches for AD clinical trial design aimed at improving our ability to identify novel therapies for this devastating disease.
Clinical Benefits of Antioxidative Supplement Twendee X for Mild Cognitive Impairment: A Multicenter, Randomized, Double-Blind, and Placebo-Controlled Prospective Interventional Study
Authors: Tadokoro Koh , Morihara Ryuta , Ohta Yasuyuki , Hishikawa Nozomi , Kawano Satoko , Sasaki Ryo , Matsumoto Namiko , Nomura Emi , Nakano Yumiko , Takahashi Yoshiaki , Takemoto Mami , Yamashita Toru , Ueno Setsuko , Wakutani Yosuke , Takao Yoshiki , Morimoto Nobutoshi , Kutoku Yumiko , Sunada Yoshihide , Taomoto Katsushi , Manabe Yasuhiro , Deguchi Kentaro , Higashi Yasuto , Inufusa Haruhiko , You Fukka , Yoshikawa Toshikazu , von Greiffenclau Markus Matuschka , Abe Koji
Published: August 2019

Oxidative stress is part of the entire pathological process that underlies the development of Alzheimer’s disease (AD), including the mild cognitive impairment (MCI) stage. Twendee X (TwX) is a supplement containing a strong antioxidative mix of eight antioxidants, which has been shown to have a clinical and therapeutic benefit in AD model mice. Here, we conducted a multicenter, randomized, double-blind, and placebo-controlled prospective interventional study to evaluate the efficacy of TwX in mitigating MCI. The primary outcomes were differences in Mini-Mental State Examination (MMSE) and Hasegawa Dementia Scale-revised (HDS-R) scores between baseline and six months for placebo and TwX groups. Seventy-eight subjects with MCI were randomized into placebo ( n = 37) and TwX ( n = 41) groups. MMSE scores at six months differed significantly between the TwX and placebo groups ( p = 0.018), and HDS-R scores for the TwX group exhibited a significant improvement at six months relative to baseline ( p = 0.025). The TwX group did not show any change in affective or activities of daily living scores at six months. The present study indicates that strong antioxidative supplement TwX is clinical beneficial for cognitive function in subjects with MCI.
Depressive Symptoms and Cognitive Improvement in Patients with Dementia with Lewy Bodies
Authors: Pyun Jung-Min , Kang Min Ju , Youn Young Chul , Park Young Ho , Kim SangYun
Published: August 2019

Background:

Although dementia with Lewy bodies (DLB) is a degenerative disease involving irreversible pathological changes and subsequent progressive cognitive decline, some patients have presented with improved cognitive function at follow-ups. Their clinical and neuropsychological characteristics and the factors influencing this improvement remain unclear.

Objective:

To investigate differences in clinical and neuropsychological characteristics between DLB patients with and without cognitive improvement at a one-year follow-up, and to identify predictive factors of cognitive improvement.

Methods:

This retrospective study included 60 DLB patients, 28 patients in the improved group, and 32 patients in the non-improved group. A multiple linear regression model was used to compare changes in cognitive function test scores between groups over the course of one year. Binary logistic regression analysis was performed to determine the odds ratios (ORs) of depressive symptoms as a predictor for cognitive improvement.

Results:

The improved group showed significant increases in immediate and delayed verbal memory function in one year over the non-improved group. We also found that baseline depressive symptoms were associated with an increased probability of cognitive improvement (OR 1.234, CI 1.043– 1.460).

Conclusion:

Depressive symptoms at baseline were related to a higher probability of a cognitive improvement at one-year follow-up. In addition, immediate and delayed verbal memory function showed significant improvement during one year in improved patients compared to non-improved patients.
RETRACTED: Two new polyoxometalate containing coordination polymers: Crystal structures and anti-oral cancer activity evaluation
Authors: Feng Song
Published: August 2019

This article has been retracted, and the online PDF has been watermarked “RETRACTION”. The retraction notice is available at http://doi.org/10.3233/MGC-220954 .
RETRACTED: Novel pyran derivatives: Crystal structures and inhibiting human cervical cancer cells evaluation
Authors: Lv Guang , Li Wen-Jun , Chen Wei-Yong , Xia Ying
Published: August 2019

This article has been retracted, and the online PDF has been watermarked “RETRACTION”. The retraction notice is available at http://doi.org/10.3233/MGC-220954 .
Practical recommendations for the transition to adulthood for the adolescent with a genetic diagnosis. Special emphasis on inborn errors of metabolism
Authors: De Castro Mauricio , Turner Clesson , Kirmse Brian
Published: August 2019

Taken as a group, genetic disorders affect a significant proportion of the population. Historically thought of as pediatric disorders, inborn errors of metabolism (IEM) are becoming increasingly relevant to the adult clinical provider; given the improvements in screening, diagnosis and management, an increasing number of children with IEM’s are able to transition adulthood. Currently available data suggests that adult-medicine clinical providers are ill-prepared to appropriately care for this population. Although practical management and transition guidelines exist for a minority of disorders, there is a significant lack of guidance for the great majority of conditions. Based on our review of the relevant literature, we set out to provide practical recommendations to assist in the transition from adolescence to adulthood, with an emphasis on patients with an inborn error of metabolism.
How do I treat when there is no treatment?
Authors: Regier Debra S. , Hallie Andrew E. , Bloom Miriam , Fisher Deborah
Published: August 2019

The majority of children in hospice care do not have cancer, but many have rare diseases. Thus, it is essential that rare disease specialists have a functioning knowledge of the palliative care system and its role in meeting the unique needs of pediatric patients with genetic disorders or inborn errors of metabolism. Creating a team of providers that both understands the natural history of the specific rare disease and truly understands the principles of palliative care leads to optimal outcomes for patients. Here, we discuss the importance of genetic counseling and describe the basic tenants of palliative care. By approaching this topic from a rare disease perspective, we discuss the unique features of improving quality of life for patients and families. In addition, we discuss the role of self-care in preventing care provider burnout of families and medical providers. The thoughtful approach to palliation in rare diseases is essential to optimize the experience for all participants in a patient’s shortened life.
Challenges in the diagnosis of calyceal diverticulum: A report of two cases and review of the literature
Authors: Zhang Zejian , Zhang Yixiang , Wang Xisheng , Chen Dong , Peng Naixiong , Chen Jicheng , Bleyer Anthony , Wang Qinjun , Liu Yunfei , Zhang Yuanyuan
Published: August 2019

Background:

Calyceal diverticula outpouchings that occur rarely in the upper collecting system of the kidney and is often difficult to detect. In this study, we present two cases of calyceal diverticula and discuss their clinical characteristics and radiologic features.

Patients and methods:

In the presented two cases, we applied several imaging examinations, including delayed intravenous pyelography, retrograde pyelography and axial computerized tomographic (CT) scanning of the kidneys with and without contrast. Serum creatinine levels in fluid withdrawn from the diverticula were found to be significantly higher than the simultaneous serum creatinine levels. Intravenous injection of methylene blue through a ureteral catheter was also aided in the diagnosis. Calyceal diverticulum neck dilatation was performed through a percutaneous nephroscope.

Results

The two cases were diagnosed preoperatively and the operation was successful performed. The nephrostomy tube was removed seven days after surgery without complications. CT scans of the kidney after six months showed that the size of the calyceal diverticulum of two patients were considerably smaller than pre-surgery. There were no reports of pain in the lumbar region or other discomfort.

Comments:

Diagnosis of calyceal diverticulum mainly depend on a variety of imaging examinations, including the delayed intravenous pyelography, retrograde pyelography, and kidney CT plain scan plus enhanced scan. If the patient cannot be diagnosed by above methods, cyst fluid can be aspirated percutaneously to measure the preoperative creatinine level. If it is significantly higher than the serum creatinine level, the cyst fluid is considered urine, which can assist in the diagnosis of calyceal diverticulum. A ureteral catheter should also be inserted before operation namely, intravenous injection of methylene blue through a ureteral catheter is helpful for diagnosis. The choice of surgical treatment is based on the size and location of calyceal diverticulum and clinical manifestations.
Screening for Driver Disorientation at the Iowa Department of Transportation, Motor Vehicle Division
Authors: Andrade Sarah , Hill Linda , Snook Kim
Published: August 2019

Background and Purpose: Aging is associated with cognitive impairment, which interferes with safe driving ability. Cognitively-impaired drivers may present as confused and belligerent, creating challenges in differentiating these drivers from intoxicated or metabolically-impaired drivers. The Driver Orientation Screen for Cognitive Impairment (DOSCI) was developed to assist identification of disorientation and was piloted in the Iowa Department of Transportation. This study examined the feasibility, acceptability, and usefulness of the DOSCI at licensing agency offices, and to investigate the association between DOSCI performance and driver licensing outcomes. Methods: A sample of 2,510 DOSCI screens from 2,399 individuals was assessed. Data included the acceptability of the DOSCI among staff and clients, time to complete assessments, DOSCI outcomes, and final driver license status. Results: On a 5-point scale, mean score was 4.76 (SD=0.67) for Ease of Administration, 4.67 (SD=0.80) for Acceptance by Client, and 3.81 (SD=1.57) for Useful in Assessment. Clients who failed the assessment had significantly higher odds of not receiving a driver’s license than clients who passed (OR=2.556). Conclusion: The DOSCI was quick to administer, well-accepted, and was associated with licensing outcome. The tool has potential to contribute to traffic injury prevention by identifying potentially impaired drivers requiring closer examination in a licensing agency setting.
Botanical, genetic characteristics and preliminary screening of the phytochemical constituents of Hydnophytum formicarum Jack. in Phu Quoc forest, Vietnam
Authors: Trac Mai Nguyen Ngoc , Dep Truong Thi , Anh Tran Thi Van , Tuoi Do Thi Hong
Published: August 2019

In Vietnamese folk medicine, Bi ky nam (H. formicarum) tuber has been widely used to treat rheumatism, liver and intestinal diseases. This work aimed to study botanical, genetic characteristics and screening of the phytochemical constituents of wild H. formicarum of Phu Quoc Island, Vietnam. Anatomical characteristics of the plant material were described. Fresh leaves were used to analyze DNA barcodes based on rbcL region amplified by PCR. Sequences of DNA products were identified by Sanger method and BioEdit 7.0.5 software, then compared to the control rbcL sequences published in GenBank by BLAST. The tuber powder was studied for pharmacognostic parameters, preliminary phytochemical screening and total phenolic contents by Folin-Ciocalteu method. Results showed that the similarity between the rbcL sequences of H. formicarum leaves collected in Phu Quoc and the control one published in Genbank was 99%. Moisture content, total ash value and acid insoluble ash value of dried tuber powder were 11.06%, 9.60% and 0.70%, respectively. Raw material contained carotenoids, triterpenoids, flavonoids, phenolics, tannins, saponins, reducing substances and amino acids. Total phenolics content was about 58.847 mg pyrrogallol equivalent/g dried powder weight. Our results provided information about botanical, genetic and preliminary phytochemical characteristics of H. formicarum growing on Phu Quoc Island. This could be useful for the authentication of H. formicarum as a medicinal material.
Salud docente y seguridad laboral en la Facultad Ciencias de la Salud de la Universidad Privada Antonio Guillermo Urrelo, Cajamarca.
Authors: Ortiz Marreros Milagros , Delgado Céspedes Víctor
Published: August 2019

La investigación tuvo como objetivo determinar la relación que existe entre la salud docente con la seguridad laboral en la facultad de ciencias de la salud en la Universidad Privada Antonio Guillermo Urrelo, Cajamarca. El tipo de investigación fue básica de alcance descriptivo, de diseño correlacional de diseño no experimental y corte transversal, La población de estudio estuvo conformada por 69 docentes de la Universidad Privada Antonio Guillermo Urrelo. Que fue considerada fueron los docentes de la universidad que equivalen a 69 personas; los instrumentos de estudio utilizados fueron creados en relación a la primera variable (Salud del docente) lacual estuvo conformado por 20 preguntas que se relacionaron a las dimensiones fisica, mental yemocional, y el segundo instrumento fue elaborada en relación a la segunda variable (Seguridad laboral) conformada por 10 preguntas estos instrumentos fueron validadas a través de juicio deexpertos. Para el análisis de relación se utilizó el coeficiente chi cuadrado con un valor quedenota la aceptación mostrando que el nivel de significancia 0.05 así se acepta la hipótesis existiendo una relación significativa entre las variables de estudio. Entre el resultado más resaltante en cuanto a las dimensiones muestran un regular estado salud física 14.5%, Emocional un 33.3% y un regular estado mental y un 31.9% regular estado emocional entre los docentes. Esdecir, a mayor salud docente mayor la seguridad laboral.

Palabras Clave: Salud docente, seguridad laboral y riesgo laboral
Industry-Level Disparities in Antitrust Enforcement
Authors: Islam Md. Mominul , Chowdhury Imrul Hossain , Islam Sabrina
Published: August 2019

Purpose- The purpose of this study is to analyze whether an increase in the concentration of industry causes an increase in the level of the Department of Justice Antitrust Division (DoJ)’s antitrust enforcement within that industry.
Design/Methodology- The study employed secondary data and quantitative research method was also utilized to achieve the objectives of the study. Multiple regression analysis techniques were used to analyze the data.
Findings- The results support the hypothesis that an increase in the concentration of industry causes an increase in the level of Department of Justice Antitrust Division (DoJ)’s antitrust enforcement within that industry. It appears that industry-level revenue from exports is highly correlated with the size of that industry and its lobbying activity.
Practical Implications- These results have practical relevance which helps to predict the intensity of antitrust activity in future years. Its practical implication is that there are disparities in antitrust enforcement that are influenced by factors other than concentration. By creating a benchmark that takes into account components such as this, the Department of Justice Antitrust Division (DoJ) can identify those companies who are likely to be engaging in anticompetitive behavior.
KEGUGURAN PADA SAPI DIPENGARUHI OLEH TINGKAT KERUSAKAN DEOXYRIBONUCLEID ACID (DNA) SPERMA
Authors: Priyanto Langgeng , Budiyanto Agung , Kusumawati Asmarani , Kurniasih -
Published: August 2019

ABSTRAK Hubungan antara tingkat kerusakan DNA sperma dengan keguguran pada sapi belum banyak dilaporkan. Tujuan penelitian ini untuk mengetahui hubungan antara kerusakan DNA sperma dengan tingkat keguguran pada sapi Brahman dan sapi Bali, tingkat keguguran pada sapi Brahman dan sapi Bali belum banyak dilaporkan. Tingkat kerusakan DNA sperma diukur dengan Sperm-Bos-Halomax® dari dua straw sampel semen beku sapi Brahman (40002,40885) dan tingkat kebuntingan diukur dari tingkat keberhasilan inseminasi buatan pada 14 ekor sapi Brahman dan 14 ekor sapi Bali yang masing-masing dibagi menjadi dua kelompok. Satu kelompok sebanyak tujuh ekor diinseminasi buatan dengan semen pejantan 40002 dengan tingkat kerusakan DNA sperma 37,11 % dan satu kelompok lagi diinseminasi buatan dengan semen pejantan 40885 dengan tingkat kerusakan DNA sperma 10,66%. Data yang diperoleh dianalisis secara deskriptif dengan membandingkan kerusakan DNA sperma dengan tingkat keguguran. Hasil penelitian menunjukkan bahwa pada tingkat kerusakan DNA sperma 37,11% ditemukan tingkat keguguran14,31 % pada sapi Brahman dan 28,60 % pada sapi Bali, dengan pemeriksaan ultrasonografi (USG) pada hari ke-30 dan hari ke-45. Hasil penelitian pada tingkat kerusakan DNA sperma 10,66% tidak ditemukan keguguran pada pemeriksaan USG pada hari ke-30 dan USG pada hari ke-45. Berdasarkan hasil penelitian yang dilakukan dapat disimpulkan bahwa kerusakan DNA sperma 37,11 % memengaruhi keguguran pada sapi Brahman dan sapi Bali. Kerusakan DNA sperma 10,66 % tidak berpengaruh terhadap keguguran pada sapi Brahman dan sapi Bali. Kata kunci: Kerusakan DNA sperma; tingkat keguguran; sapi Brahman dan Sapi Bali
Two new species and a revised key to Rhynchomicropteron (Diptera, Phoridae)
Authors: Disney Henry
Published: August 2019

Rhynchomicopteron necaphidiforme sp. n. is described from West Malaysia, where it is associated with a Ponerine ant. The female matures a single egg at atime. Silvestri's (1947) specimen from lndo-China attributed to R. caecutietts Schmitz is recognised as a new species and named R. silvestrii sp. n. A key to the eleven known species of Rhyrtchonticropteron is provided.
A key to Diplonevra males of the Australasian and Oriental Regions, including two new species (Diptera, Phoridae)
Authors: Disney Henry
Published: August 2019

Recognition of the genus Diplonevra Lioy is clarified with respect to Dohrniphora Dahl. Dohrniphora bilineata Borgmeier is transferred to Diplonevra. A key to males of the Australasian and Oriental species is provided. Diplonevra ismayi sp. n., from Papua New Guinea, and D. prediclø sp. n., from Australia, are described.
Bucculatrix latviaella sp. n. aus Lettland (Lepidoptera, Bucculatricidae)
Authors: Šulcs Ivars
Published: August 2019

Bucculatrix latviaella sp. n. is described from Latvia. The new species flies on habitats devoid of Aster tripolium, the food plant of the closely related B. maritima Stainton It has been recorded from Latvia (9 ind.) and Finland (1 ind.).
PENERAPAN LARANGAN PEMILIKAN TANAH PERTANIAN SECARA ABSENTEE
Authors: Putra Chandra Dewangga Marditya
Published: August 2019

Untuk menjadikan masyarakat tani yang adil dan makmur maka pemerintah melalui program landreform yang meliputi perombakan mengenai kepemilikan dan penguasaan tanah serta hubungan-hubungan hukum yang bersangkutan dengan penguasaan tanah. Sesuai dengan Pasal 10 ayat (1) Undang-Undang Pokok Agraria telah mengamanahkan terkait larangan kepemilikan atas tanah pertanian secara absentee. Dengan adanya ketentuan tersebut diharapkan para pemegang hak atas tanah pertanian dapat mengusahakan atau mengerjakan sendiri tanah yang dimilikinya sehingga tanah-tanah pertanian memang menjadi produktif dan tidak terdapat tanah pertanian yang di biarkan atau absentee. Tujuan larangan absentee agar hasil yang diperoleh dari pengusahaan tanah sebagian besar dapat dinikmati oleh masyarakat desa tempat letak tanah. Fenomena larangan tanah absentee/guntai secara nyata terjadi, tetapi tidak dilakukan sanksi yang tegas.Kata kunci: absentee, kepemilikan hak atas tanah, pertanian, sanksi. To make a fair and prosperous farming community, the government through a Land Reform program which includes a reshuffle of land ownership and control as well as legal relations concerned with land tenure. In accordance with Article 10 paragraph (1) the Basic Agrarian Law mandates Absentee prohibitions on ownership of agricultural land. With the existence of these provisions it is expected that holders of agricultural land can cultivate or work on their own land so that agricultural lands are indeed productive and there is no agricultural land that is left or Absentee. The purpose of the Absentee ban is that the results obtained from the cultivation of land can be enjoyed mostly by rural communities where the land is located. The phenomenon of the prohibition of Absentee / guntai land actually occurred, but no strict sanctions were made.Keywords: absentee,ownership of rights to land, agriculture, sanctions.
PERANAN BADAN WAKAF INDONESIA DALAM PENYELESAIAN SENGKETA TANAH WAKAF
Authors: Arifin Mohammad Syamsul
Published: August 2019

Di dalam agama Islam wakaf merupakan ibadah yang bernuansa penuh dengan rasa cinta kasih terhadap sesama manusia, menyejahterakan kepentingan orang lain bahkan kepentingan umum, dengan mewakafkan harta benda maka, akan tercipta solidaritas seseorang terhadap sesamanya. Akan tetapi di lapangan sering terjadi sengketa yang didahului oleh unsur kepentingan. Dalam penyelesain sengketa menggunakan metode penyelesain sengketa di luar pengadilan atau non litigasi yaitu menggunakan metode mediasi yang di lakukan oleh nadzir dan waqif dalam penyelesaian masalah. Adapun faktor dari sengketa khusus Masjid Tawakkal adalah unsur kepentingan baik oleh wakif maupun nadzir sedangkan peranan Badan Wakaf Indonesia dalam penyelesaian sengketa wakaf adalah berpedoman pada pasal 62 ayat 1 dan 2 Undang-undang Nomer 41 tahun 2004  yaitu BWI dalam penyelesaian  sengketa wakaf  mengedepankan musyawarah mufakat.Kata kunci: penyelesain sengketa, wakaf, nadzir dan wakif In Islam, waqf is nuanced worship full of love for fellow human beings, welfare of the interests of others and even public interests, by endowing property, there will be a solidarity between one another. However, in the field there are often disputes which are preceded by elements of interest. In resolving disputes using the method of resolving disputes outside the court or non-litigation, namely using the mediation method that is done by Nadzir and Waqif in solving problems. The factors of special dispute Tawakkal Mosque are elements of interest both by wakif and nadzir while the role of the Indonesian Waqf Agency in settlement of waqf disputes is guided by article 62 paragraph 1 and 2 of Law Number 41 of 2004 namely BWI in resolving endowments disputes prioritizing consensus.Keywords: dispute resolution, waqf, nadzir and wakif
PERAN NOTARIS DALAM PENEGAKAN HAK ASASI MANUSIA
Authors: Triwahyuningsih Susani
Published: August 2019

Notaris merupakan salah satu  pelayan masyarakat yang penting atau bahkan istimewa. Pelayanannya ini berhubungan dengan perlindungan  atau penegakan hukum. Dalam ranah demikian, peran yang dilakukan oleh notaris identik dengan menegakkan hak asasi manusia (HAM), karena dari aktifitas yang dilakukannya dapat memberikan jaminan kepastian yuridis terdapa hak-hak masyarakat atau pihak yang meminta jasa layanan kepadanya. Kalau jasa layanan yang ditunjukkannya benar sesuai dengan norma yuridis, maka hal ini memosisikannya sebagai subyek yang bekomitmen terhadap HAM.Kata kunci: notaris, peran, hak asasi manusia, penegakan Notary is one of important or even special public servants. This service is related to protection or law enforcement. In this domain, the role carried out by the notary is synonymous with upholding human rights (HAM), because the activities carried out can provide a guarantee of juridical certainty on the rights of the society or the party requesting services to him. If the services shown are in accordance with juridical norms, then their positions as subjects who are committed to HAM.Keywords: notary, role, human rights, enforcement
MEDIA PENGENALAN BARONG BANGKUNG NGELAWANG DENGAN GAME 3D BARONG BANGKUNG RUNNER BERBASIS ANDROID
Authors: Suardika I Gede , Ditha Satria Dana I.G.P , Wikranta Arsa I.G.N
Published: August 2019

Barong Bangkung adalah sebuah tradisi di Bali yang dipentaskan dengan berkeliling desa atau istilahnya (ngelawang) oleh dua orang penari pada hari-hari tertentu yang dianggap keramat atau saat terjadinya wabah penyakit menyerang desa tanpa membawakan sebuah lakon dan diiringi dengan gamelan batel atau tetamburan. Perkembangan Barong ngelawang kini mengalami perubahan. Semula Barong ngelawang yang sakral, tetapi dalam perkembangannya muncul kegiatan Barong ngelawang yang dilakukan anak-anak untuk menghibur dan mencari uang. Maka diperlukan untuk membuat sebuah media yang dapat mengenalkan tradisi barong bangkung ngelawang sesuai dengan tradisi aslinya yang religius. Tujuan dari penelitian ini yaitu untuk memperkenalkan tradisi asli dari Barong Bangkung ngelawang dalam bentuk sebuah game 3D berbasis Android. Dalam membangun Game 3D Barong Bangkung Runner Berbasis Android menggunakan metode pengembangan GDLC (Game Development Life Cycle) dengan bantuan perangkat lunak Unity 3D Game Engine dengan menggunakan bahasa pemrograman C# (C-Sharp)., Blender, Adobe Photoshop, dan Audition. Bahasa pemodelan yang digunakan adalah  UML (Unified Modelling Language). Hasil dari penelitian ini berhasil menghasilkan Game 3D Barong Bangkung Runner Berbasis Android. Pengujian Game ini menggunakan metode Black Box dan hasilnya game dapat berjalan baik pada perangkat dengan RAM 3GB ke atas
Шлях впровадження та подальші перспективи інституту оцінки ризиків вчинення повторного правопорушення в Україні
Authors: ЯКОВЕЦЬ ІРИНА , АВТУХОВ КОСТЯНТИН
Published: August 2019

Завданням кримінальної юстиції є забезпечення безпеки суспільства, його захист від протиправних посягань. Для досягнення вказаної мети законодавцем кожної країни закріплюються певні механізми превенції нових правопорушень та заходи роботи з особами, що вже вчинили злочин. Радянська, а нині й сучасна українська правоохоронна система послуговується широким колом різноманітних інструментів, утім, такий механізм, як оцінка ризиків вчинення кримінального правопорушення, перебуває лише на початковій стадії впровадження в українську правничу систему. Досвід передових країн світу та міжнародних організацій свідчить про пла номірне поширення практики впровадження інструмента оцінки ризиків. Зростання популярності оцінки ризиків зумовлене запитом суспільства на безпеку, котру можна належно забезпечити науково обґрунтованими методами та політиками (evidence-basedpolicies).
Мета статті – висвітлити процес запровадження застосування інституту оцінки ризиків та подальші перспективи розширення сфер застосування оцінки ризиків в Україні.
Розвиток вітчизняної науки кримінально-виконавчого права зумовлює все більший інтерес до передових світових підходів до вирішення проблем надмірної дискреції персоналу органів та установ виконання покарань при прийнятті рішень, що впливають на правовий статус засуджених. Крім того, існує гостра потреба у науково-доведених підходах роботи з засудженими та інструментах, ефективність яких можна виміряти шляхом емпіричних досліджень та які вже пройшли апробацію у передових країнах. Інструмент оцінки ризиків вчинення кримінального правопорушення володіє всіма описаними вище характеристиками, саме тому можливо констатувати, що в майбутньому практика застосування цього інструмента лише розширюватиметься.
Розробка та впровадження окремих елементів оцінки ризиків та потреб у діяльності органів виконання покарань розпочалися ще у 2000 р. і фактично тривали понад 15 років. Цей процес супроводжувався численними проєктами, у межах яких розроблялися, апробовувалися та валідувалися різні варіації оцінки ризиків. Фактичний результат цього процесу був оформлений у прийнятому у 2015 р. Законі України “Про пробацію”, у якому цей інструмент фігурує серед елементів досудової доповіді та в аспекті здійснення соціально-виховної роботи з засудженими. Утім, процес запровадження в Україні оцінки ризиків триває, і вже в зареєстрованих законопроектах, що перебувають на розгляді у Верховній Раді України, оцінка ризиків набуває все масштабнішого застосування, зокрема у законопроекті № 7337 “Про пенітенціарну систему”.
Electrode movement prevention – an animal model
Authors: Masopust V. , Petríková I. , Mlček M. , Holubová J. , Rokyta R. , Fricová J. , Janoušková K.
Published: August 2019

Electrode migration is the most common complication of spinal cord stimulation (SCS). The problem of longitudinal migration has already been solved, but lateral migration remains the most common current complication. The present article describes new electrodes fixation opportunities for the reduction of lateral migration in SCS. The pig was chosen as an animal model to illustrate a new protocol of electrode fixation for the control of lateral and longitudinal migration. The displacement of the electrode was measured using two different optical methods: the digital image stereo-correlation and the digital image processing methods. Fixation with two anchors has always considerably reduced electrode displacement and when fixation is done with two anchors and a loop then lateral migration is reduced by 62.5 % and longitudinal migration is reduced by 94.1 %. It was shown that the results are significantly different at the α=0.001 significance level. Based on a statistical evaluation it is possible to state that the differences between experimental results obtained for three different protocols of lead fixation are statistically significant and we can recommend the new fixation method for common practice.
Two types of high inductive electromagnetic stimulation and their different effects on endothelial cells
Authors: Průcha J. , Skopalik J. , Socha V. , Hanáková L. , Knopfová L. , Hána K.
Published: August 2019

Effects of low-frequency electromagnetic fields (LF EMF) on the activation of different tissue recovery processes have not yet been fully understood. The detailed quantification of LF EMF effects on the angiogenesis were analysed in our experiments by using cultured human and mouse endothelial cells. Two types of fields were used in the tests as follows: the LF EMF with rectangular pulses, 340-microsecond mode at a frequency of 72 Hz and peak intensity 4 mT, and the LF EMF with sinusoidal alternating waveform 5 000 Hz, amplitude-modulated by means of a special interference spectrum mode set to a frequency linear sweep from 1 to 100 Hz for 6 s and from 100 Hz to 1 Hz return also for 6 s, swing period of 12 second. Basic parameters of cultured cells measured after the LF EMF stimulus were viability and proliferation acceleration. Both types of endothelial cells (mouse and human ones) displayed significant changes in the proliferation after the application of the LF EMF under conditions of a rectangular pulse mode. Based on the results, another test of the stimulation on a more complex endothelial-fibroblast coculture model will be the future step of the investigation.
To the approximate size of the nuclear region occupied by nucleolar bodies during cell differentiation and maturation using the human leukemic granulocytic lineage as a convenient model
Authors: Smetana K. , Klamová H. , Mikulenková D.
Published: August 2019

The present study was undertaken to estimate the approximate size of nuclear regions occupied by nucleolar bodies during the cell differentiation and maturation. The differentiation and maturation of human leukemic granulocytic cells in patients suffering from the chronic phase of the chronic granulocytic leukemia (CML) represented a convenient model for such study because of the large number of cells for the diameter measurements at the single cell level. Early and advanced differentiation or maturation stages of these cells are well defined and nucleolar bodies and nuclear outlines are easily seen by simple cytochemical methods for the visualization of RNA and silver stained proteins in smear preparations. During the cell differentiation and maturation, the estimated size of the nuclear region occupied by nucleolar bodies decreased in both untreated and treated patients with the anti-leukemic therapy. However, the size reduction of nucleolar bodies in differentiated and mature cells was larger than that of the nucleus. In addition, the results also indicated that the nuclear region occupied by nucleolar bodies was characteristic for each differentiation and maturation stage of the granulocytic cell lineage and was not substantially influenced by the anti-leukemic therapy of CML patients.
Sex-linked differences in the mortality in Ren-2 transgenic hypertensive rats with aorto-caval fistula: effects of treatment with angiotensin converting enzyme alone and combined with inhibitor of soluble epoxide hydrolase
Authors: Kala P. , Červenka L. , Škaroupková P. , Táborský M. , Kompanowska-Jezierska E. , Sadowski J.
Published: August 2019

We found recently that in Ren-2 transgenic hypertensive rats (TGR) addition of soluble epoxide hydrolase inhibitor (sEHi) to treatment with angiotensin-converting enzyme inhibitor (ACEi), surprisingly, increased the mortality due to heart failure (HF) induced by creation of the aorto-caval fistula (ACF). Since TGR exhibit sex-related differences in mortality, we examined here if such differentiation exists also in the response to the treatment with ACEi (trandolapril), alone or combined with sEHi [cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid, (c-AUCB)]. ACEi improved survival in males to 74 % (vs. 0 %) and in females to 65 % (vs. 32 %). ACEi and sEHi combined also improved the survival in male ACF TGR, however, it was significantly less (38 %) than after ACEi alone. In contrast, in females the combined treatment significantly improved the final survival rate (84 %). There were no significant sex-linked differences in survival rate in untreated or treated normotensive Hannover Sprague-Dawley rats. In conclusion, in HF patients with co-existing hypertension and RAS hyperactivity, the sex may co-determine the rate of HF progression, and can influence the effectiveness of the therapeutic measures applied. Therefore, in the relevant pre-clinical studies the sex-linked differences should be seriously considered. Our data indicate that TGR might be an optimal model for such studies.
Chemokine (C-X-C motif) receptor 4 regulates lung endothelial barrier permeability during resuscitation from hemorrhagic shock
Authors: Babu F.S. , LaPorte H.M. , Nassoiy S.P. , Majetschak M.
Published: August 2019

Chemokine (C-X-C motif) receptor 4 (CXCR4) agonists have been shown to protect lung endothelial barrier function in vitro. In vivo effects of CXCR4 modulation on lung endothelial permeability are unknown. Here we tested the effects of the CXCR4 agonist ubiquitin and the antagonist AMD3100 on lung vascular permeability and cytokine concentrations in a rat hemorrhage model. Animals were hemorrhaged (mean arterial blood pressure 30 mmHg for 30 min), treated with vehicle, ubiquitin (0.7 and 3.5 μmol/kg) or AMD3100 (3.5 μmol/kg), and resuscitated with crystalloids. Evans blue extravasation was employed to quantify lung vascular permeability. Ubiquitin dose-dependently reduced Evans blue extravasation into the lung. AMD3100 increased Evans blue extravasation. With AMD3100, TNFα levels in lung homogenates were increased; while TNFα levels were lower with ubiquitin, these differences did not reach statistical significance. Our findings suggest that CXCR4 regulates lung vascular permeability and further point towards CXCR4 as a drug target to confer lung protection during resuscitation from traumatic-hemorrhagic shock.
Voluntary exercise may activate components of pro-survival risk pathway in the rat heart and potentially modify cell proliferation in the myocardium
Authors: Lonek L. , Puhova A. , Griecsova-Kindernay L. , Patel S.P. , Zohdi V. , Jezova D. , Ravingerova T.
Published: August 2019

Although physical exercise is known to reduce size of infarction, incidence of ventricular arrhythmias, and to improve heart function, molecular mechanisms of this protection are not fully elucidated. We explored the hypothesis that voluntary running, similar to adaptive interventions, such as ischemic or remote preconditioning, may activate components of pro-survival (RISK) pathway and potentially modify cell proliferation. Sprague-Dawley adult male rats freely exercised for 23 days in cages equipped with running wheels, while sedentary controls were housed in standard cages. After 23 days, left ventricular (LV) myocardial tissue samples were collected for the detection of expression and activation of RISK proteins (WB). The day before, a marker of cell proliferation 5-bromo-2'-deoxyuridine (BrdU) was given to all animals to detect its incorporation into DNA of the LV cells (ELISA). Running increased phosphorylation (activation) of Akt, as well as the levels of PKCε and phospho-ERK1/2, whereas BrdU incorporation into DNA was unchanged. In contrast, exercise promoted pro-apoptotic signaling - enhanced Bax/Bcl-2 ratio and activation of GSK-3β kinase. Results suggest that in the rat myocardium adapted to physical load, natural cardioprotective processes associated with physiological hypertrophy are stimulated, while cell proliferation is not modified. Up-regulation of pro-apoptotic markers indicates potential induction of cell death mechanisms that might lead to maladaptation in the long-term.
GFP transgenic animals in biomedical research: a review of potential disadvantages
Authors: Lipták N. , Bősze Z. , Hiripi L.
Published: August 2019

Green Fluorescent protein (GFP) transgenic animals are accepted tools for studying various physiological processes, including organ development and cell migration. However, several in vivo studies claimed that GFP may impair transgenic animals’ health. Glomerulosclerosis was observed in transgenic mice and rabbits with ubiquitous reporter protein expression. Heart-specific GFP expression evoked dilated cardiomyopathy and altered cardiac function in transgenic mouse and zebrafish lines, respectively. Moreover, growth retardation and increased axon swelling were observed in GFP and yellow fluorescent protein (YFP) transgenic mice, respectively. This review will focus on the potential drawbacks of the applications of GFP transgenic animals in biomedical research.
Modelos de aprendizaje virtuales y presenciales en lecto-escritura
Authors: Gonzalez Valencia Heriberto , Villota Enríquez Jakeline Amparo , Riofrio Bastos Efren Alberto
Published: August 2019

Este artículo de investigación es el resultado de la comparación de los modelos de aprendizaje virtual y presencial que se desarrollan en el curso de Lecto-escritura vinculado al programa Técnico Laboral en Locución ofertado en el Instituto Nacional de Telecomunicaciones – INSTEL en la ciudad de Santiago de Cali con ochenta (80) estudiantes de primero, segundo y tercer semestre respectivamente, donde se caracterizaron los modelos de aprendizaje de la asignatura. Para ello se utilizó una metodología cualitativa, estableciendo criterios de análisis a través de los conceptos de modelos de aprendizaje en entornos virtuales y presenciales, se hizo un análisis de la documentación obtenida con la realidad conceptual en los dos entornos de aprendizaje y se realizó una revisión de las propuestas de los módulos, tanto presencial como virtual con el propósito de encontrar semejanzas y diferencias que pudieran establecer la pertinencia o relevancia en términos teóricos y prácticos, entendiendo los modelos como el resultado de las dinámicas sociales y culturales presentes en el contexto educativo a nivel nacional e internacional. Finalmente se concluye que el modelo virtual -B-learning- tiene diferentes contrastes con el modelo presencial entre ellos espacio-tiempo lo cual se muestra como una tendencia moderna en la educación actual.
Niveles de Ruido en un Centro de Desarrollo Infantil de Popayán– Colombia
Authors: Muñoz Caicedo Augusto , Silva Samboni Leidy
Published: August 2019

Objetivo: determinar los niveles de presión sonora (NPS) en un Centro de Desarrollo Infantil (CDI) de Popayán –Cauca. Métodos: estudio descriptivo, transversal en una población objetivo de 341 sujetos. Se evaluó los NPS en diez aulas académicas, el área administrativa, la ludoteca, el comedor, el pasillo, el jardín social, el patio de juegos y el parqueadero. La medición se llevó a cabo durante una semana, en varios momentos como la hora de llegada, hora de salida, hora de desayuno, hora de almuerzo y en el descanso de los niños. Para la medición del NPS se utilizó un sonómetro digital calibrado (Sound Meter). Resultados: El día con mayor NPS fue el martes con 77 dB, seguido del  día  viernes con 75. El aula con mayor NPS (82 dB) fue Jardín C, mientras que las aulas de Sala cuna y Párvulos B, presentaron NPS más bajos (72 dB). El lugar con menos NPS fue la ludoteca con 59 dB, contrario al comedor con 80 dB. Los NPS más altos se presentaron en la hora de llegada de los niños al CDI, la hora de salida y la hora del almuerzo con un promedio de 83 dB. Conclusiones: Los NPS encontrados superan los límites permitidos según la normatividad colombiana y de no tomarse medidas preventivas, pueden convertirse en un riesgo para la audición e incidir en el adecuado desarrollo del lenguaje y en el desempeño escolar.
Inteligencia emocional en aprendices de tecnología en banca y operaciones financieras. SENA, Centro de Comercio Regional Antioquia
Authors: Vicuña de Rojas Jenny Josefina
Published: August 2019

El presente artículo muestra los resultados de un estudio descriptivo cuyo objetivo fue determinar el nivel de Inteligencia Emocional (IE) y sus dimensiones en los estudiantes que ingresaron al Servicio Nacional de Aprendizaje, Centro de Comercio, Regional Antioquia. La metodología fue cuantitativa con diseño descriptivo. La población estuvo conformada por 128 aprendices de nuevo ingreso, cursantes de la tecnología en Banca y Operaciones Financieras. Para la recolección de datos se utilizó un cuestionario elaborado por la autora. Los datos recogidos analizados mediante técnicas de la estadística descriptiva. Los resultados demostraron que de la población de estudiantes que ingresaron a dicho programa de formación en el SENA un 51,56% de los individuos tiene un nivel de Inteligencia Emocional Medio-Alto.
Abuso de sustancias psicoactivas. Modelo y terapia cognitiva
Authors: Toro Tobar Ronald Alberto
Published: August 2019

El objetivo de la revisión fue presentar los fundamentos del modelo cognitivo y la terapia cognitiva para el abuso de sustancias psicoactivas. Se llevó a cabo un análisis del modelo de Beck y la terapia cognitiva, tratamiento basado en la identificación de las distorsiones cognitivas, pensamientos automáticos, creencias intermedias adictivas y permisivas, y los comportamientos compensatorios derivados de la cognición y el 'antojo'. Acto seguido, se presentan los elementos claves para llevar a cabo una evaluación adecuada de los casos de trastornos adictivos, la formulación cognitiva de caso y la planeación de la terapia cognitiva. Además, se presenta un panorama de la evidencia empírica disponible, la cual fundamenta estos tratamientos denominados CBT entre los más recomendados, principalmente cuando se llevan a cabo de la mano de la ingesta de fármacos como el Naltrexone. Finalmente, se mencionan técnicas recientes basadas en la meditación y la modificación cognitiva, entre otras que la eficacia de la evaluación.