bluuebunny/crossref_metadata_2025 huggingface dataset:
A infância perdida: o corpo vivido pede passagem nas séries iniciais do Ensino Fundamental
Authors: Alexandrino Daniela Fantoni De Lima , De Lima Cintia Lucia , Ferreira Maria Elisa Caputo
Published: July 2014

Esta pesquisa teve como objetivo refletir, atravs de um levantamento bibliogrfico, a vivncia corporal nas sries iniciais do ensino fundamental. Observamos que a maior preocupao de nosso governo, e porque no dizer de nossa sociedade, com a sistematizao de nosso ensino. Fala-se muito nas instituies, infraestrutura, a organizao do ensino-aprendizagem, mas pouco se fala da vivncia corporal. Sabemos que as crianas nessa faixa etria necessitam de grande movimentao, precisam de brincar, de gestualizar seus sentimentos, pois, assim que o ensino-aprendizagem acontece. Para tanto, devemos (re)pensar a forma como nossa Educao estruturada e trazer de volta o corpo vivido. Corpo este, considerado como o lugar onde as experincias, as subjetividades, as emoes e o aprender vo emergir, influenciando assim como o futuro adulto vai se comportar no mundo. Enfim, devemos resgatar o conceito de infncia que vai se tecer e se alimentar atravs do corpo vivido pela criana.
Para além da coesão textual apenas como elos coesivos
Authors: Garantizado Júnior José Olavo Da Silva , Cavalcante Mônica Magalhães
Published: July 2014

O presente trabalho tem como objetivo (re)discutir as noes de coerncia e de coeso que no dependam exclusivamente de propriedades inerentes organizao dos elementos no cotexto, mas, sim, de um contexto sociocultural mais amplo, o que inclui uma srie de atividades interpretativas dos coenunciadores. Para isso, inicialmente, apresentaremos os conceitos de linguagem, de lngua, de texto e de textualidade a partir da viso sociointeracionista (KOCH, 2009b, GARANTIZADO JNIOR, 2011, CAVALCANTE, 2011). (Re)discutimos os critrios de coerncia e coeso propostos por vrios tericos da Lingustica de Texto (HALLIDAY e HASAN, 1976; BEAUGRANDE e DRESSLER, 1981; CHAROLLES, 1978; COSTA VAL, 2006), destacando a maneira como todas as abordagens entenderam tais fenmenos para, em seguida, confrontarmo-las com a perspectiva terica apresentada por Cavalcante (2011) e sustentada por ns (GARANTIZADO JNIOR, 2011). Assumimos a coerncia e a coeso como um como um par inseparvel (coerncia/coeso), algo que no pode ser visto de maneira dissocivel, pois caminham juntas; a coeso no est relacionada apenas ao que de natureza interna do texto (aos mecanismos interiores do texto que, em outras pesquisas, seriam atribudas somente coeso e coerncia semntica), mas, sim, tambm a fatores de natureza pragmtica, cognitiva e sociointeracional.
Gestão democrática da educação: por entre concepções e tendências
Authors: Espíndola Fernandes Maria Dilnéia , Alves Andréia Vicência Vitor , Alves Andressa Gomes de Rezende
Published: July 2014

O trabalho apresenta a gesto democrtica do ensino enquanto princpio constitucional e sua delegao as unidades federativas pela Lei 9.394/1996. A partir da reviso da literatura, desvelam-se diferentes concepes de gesto de educao que demonstra que esse um campo em disputa, principalmente a partir dos anos de 1990, quando ganham centralidade modelos de gesto da educao distintos da gesto democrtica. Conclui-se que, no contexto de modernizao do Estado brasileiro, a gesto democrtica do ensino enquanto princpio constitucional tem convivido de forma subsumida a outros modelos de gesto da educao.
Configuração educativa em Portugal, em globalização e europeização: Que riscos para a democratização?
Authors: Macedo Eunice , Araújo Helena Costa
Published: July 2014

A configurao educativa, em Portugal, articula-se com a reconfigurao social, poltica, econmica e cultural global, incluindo a produo poltica europeia. A estas subjazem concepes de educao cada vez mais associadas quantificao de resultados escolares e atribuio de qualificaes teis ao mercado de trabalho, bem com uma organizao escolar crescentemente hierarquizada e menos democrtica que exclui grande nmero de crianas e jovens, particularmente as dos grupos mais desfavorecidos. Este texto contextualiza o fenmeno educativo portugus na globalizao e europeizao e analisa transformaes na organizao do sistema educativo e da escola, que parecem poder pr em risco uma efetiva democratizao.
Perfil e Formação de Gestores Escolares no Brasil
Authors: Vidal Eloisa Maia , Vieira Sofia Lerche
Published: July 2014

Este trabalho discute e aprofunda questes relativas ao perfil e formao dos gestores escolares no Brasil, tomando por base informaes disponveis sobre esses profissionais da educao no Questionrio do Diretor da Prova Brasil 2011, disponibilizadas pelo Instituto Nacional de Estudos e Pesquisas Educacionais Ansio Teixeira (INEP). As informaes referem-se a uma amostra de 56.222 respondentes, perfazendo um total de 36,1% de representantes desses profissionais. Tais indicadores so discutidos luz dos dispositivos legais acerca da matria e de outras consideraes que contribuem para situar a questo dos diretores no mbito das polticas de formao. Os dados analisados so contejados com pesquisa realizada pelo Segundo Estudio Regional Comparativo y Explicativo (SERCE) desenvolvido pelo Laboratrio Latinoamericano de Avaliao da Qualidade da Educao (LLECE) entre 2006 e 2009. Os dados evidenciam ser alto o percentual de educadores com formao de nvel superior, em particular na rea de Pedagogia. Tambm bastante expressivo o quantitativo de gestores escolares com especializao e modalidades diversas de formao continuada. O perfil delineado aponta para a relevncia de aprofundar estudos sobre o tema, especificamente em pesquisas de natureza quanti-qualitativa, com vistas a fornecer subsdios para o delineamento de politicas pblicas mais articuladas com as demandas desses profissionais.
The uses of Betula pendula Roth among Hungarian Csángós and Székelys in Transylvania, Romania
Authors: Papp Nóra , Czégényi Dóra , Hegedűs Anita , Morschhauser Tamás , L. Quave Cassandra , Cianfaglione Kevin , Pieroni Andrea
Published: July 2014

The aim of this work is to evaluate the ethnobotanical and ethnopharmacological use of Betula pendula Roth in various regions of Transylvania, in East and Central Romania. Silver birch is an important pioneer species in the country, which has traditionally been used in ethnomedicine, households and various customs. Among the ethnic groups, 55 informants from the Csángós and 68 from the Székelys were interviewed in six villages during field studies occurring between 2007 and 2012. Informants were asked questions about the medical and non-medical applications of B. pendula, focusing on the use of the leaf and woody parts in tools and customs, and on the collection and use of birch sap with its temporal change in local ethnomedicinal knowledge. Differences related to the use of birch among the studied areas were observed. The folk remedies prepared from the sap (“virics”) and leaves were documented in local customs, with similar symbolic roles assigned to birch used in other countries. Sap collection was performed during interviews and by manual means. Four special section types on the trunk were presented, and data concerning the nutritional and ethnomedicinal use of the sap was recorded. Both the significance and use of birch sap have drastically decreased in Transylvania due to the appearance of new phytotherapeutical sources and to social changes caused by migration of young people. We found that this phenomenon is gradually leading to the disappearance traditional harvesting techniques, frequency of use and ethnomedicinal knowledge concerning B. pendula in the studied regions.
L’énigme topographique de Gibea
Authors: Lemardelé Christophe
Published: July 2014

Tout récemment, l’archéologue Israel Finkelstein a récusé l’identification du site de Tell el-Ful comme pouvant être la cité biblique de Gibea. Sans remettre en cause sa lecture de la stratigraphie du site, il apparaît toutefois qu’on ne peut tirer de conclusion définitive à partir des données d’un site confrontées trop directement à ce que dit la Bible. En effet, si l’on procède à une « archéologie » des mentions de la ville dans les textes bibliques, il ressort qu’elle ne fut pas la cité fortifiée de Saül et que le massacre des habitants de Gibea peut être envisagé comme postérieur à ce roi, bouleversant la chronologie biblique habituelle. Pour faire de l’histoire avec la Bible, il importe de se baser sur une archéologie scientifique mais également sur une critique des textes bibliques totalement émancipée de leurs enjeux théologiques.
La Jérusalem souterraine du temps d’Ézéchias
Authors: Gorea Maria
Published: July 2014

L’histoire de la découverte à Jérusalem d’un système hydraulique complexe sous la colline méridionale où fut creusé le tunnel de Siloé et de l’une des inscriptions hébraïques de la plus haute importance pour cette région avare en documents de nature épigraphique illustre de quelle manière une série de faits, dont certains fortuits, s’est posée à l’origine d’une reconstitution qui a mobilisé et continue de le faire des spécialistes du terrain et ceux du texte biblique, en brisant les barrières disciplinaires.
Situation sociale de la Galilée d’Antipas et de Jésus
Authors: Michaud Jean-Paul
Published: July 2014

Les recherches sur le Jésus de l’histoire se sont concentrées récemment sur le contexte social de la Galilée d’Hérode Antipas, milieu qui fut aussi celui de Jésus de Nazareth. Deux positions séparent actuellement les spécialistes. La première, basée spécialement sur les modèles sociaux, présente, comme contexte de l’activité de Jésus, une Galilée déchirée par de graves conflits économiques et sociaux. La seconde, au contraire, se basant sur les données archéologiques disponibles, dessine le portrait d’une Galilée plutôt économiquement florissante au ier siècle. Galilée selon les modèles ou Galilée selon ce qu’en découvre l’archéologie sur le terrain ? L’article montre que l’interprétation de crise, issue des projections catastrophiques des modèles, n’est pas confirmée par les recherches archéologiques récentes.
Jésus de Nazareth et l’archéologie de la Galilée
Authors: Piovanelli Pierluigi
Published: July 2014

La recherche actuelle sur le Jésus de l’histoire s’efforce de recontextualiser l’homme de Nazareth dans la société et la culture qui furent les siennes. Pour ce faire, il est primordial de pouvoir déterminer quel était le niveau de la romanisation de la Galilée au ier siècle de notre ère, s’il y avait des tensions sociales, des phénomènes d’acculturation ou de résistance. Les données archéologiques suggèrent que, en dépit de la prospérité et du calme apparents, les communautés rurales de la Galilée refusèrent d’adhérer aux valeurs du monde romain. Trois ouvrages récents se signalent tout particulièrement pour la volonté de leurs auteurs de réinscrire Jésus dans une perspective régionale galiléenne.
1 Corinthiens et l’archéologie : douze dossiers-test
Authors: Gerber Daniel
Published: July 2014

Quel profit y a-t-il à interroger l’archéologie pour commenter la première lettre de Paul aux Corinthiens, alors même que les communautés pauliniennes des premiers temps n’ont pas laissé de traces visibles de leur existence ? Une reprise critique de douze dossiers-test, s’appuyant entre autres sur les actes de travaux interdisciplinaires publiés en 2005 et en 2010, tente de répondre à cette question relancée en 1983 par Jerome Murphy O’Connor. Si l’éclairage qu’apporte l’archéologie sur l’épître envoyée à ceux qui construisaient leur identité en Christ dans la cité isthmique vers le milieu du premier siècle est le plus souvent indirect, son apport est cependant loin d’être négligeable, dans la mesure où cette discipline s’intéresse aujourd’hui également au quotidien des petites gens.
Le prix Architecture de bibliothèques et de centres d’archives du Québec
Authors: Lacroix Yvon-André
Published: July 2014

Le prix Architecture de bibliothèques et de centres d’archives du Québec est un prix bisannuel qui a été créé par le Congrès des milieux documentaires du Québec en 2011. Cet article retrace l’origine du prix en 2010, la mise en place des règlements et, pour les années 2011 et 2013, la formation du jury, la remise du prix et d’une mention honorifique. Chacune des sept candidatures de 2011 et des neuf candidatures de 2013 est illustrée d’une photographie. Les commentaires du jury de 2011 expriment les qualités de la lauréate du prix 2011, la Bibliothèque Raymond-Lévesque de la Ville de Longueuil, ainsi que celles de la mention accordée à la Bibliothèque de l’Université Laval. Quant à eux, les commentaires du jury du prix 2013 expriment les qualités de la lauréate de 2013, la Bibliothèque Laure Conan, de la Ville de La Malbaie, ainsi que celles de la mention accordée à la Bibliothèque Memphrémagog de la Ville de Magog.
Un espace pour chacun… Quand les expertises dialoguent
Authors: Delorme Silvie , Bélanger Jacques , Desmeules Robert
Published: July 2014

La Bibliothèque de l’Université Laval à Québec a mené, en 2009, un important projet de réaménagement et de reconceptualisation des services de la Bibliothèque des sciences humaines et sociales au Pavillon Jean-Charles-Bonenfant. Les trois articles qui suivent proposent trois visions différentes des membres de l’équipe du projet : deux représentants du client (Université Laval), soit la directrice de la bibliothèque et le directeur du Service des immeubles, ainsi que l’architecte consultant chargé de projet. Dialogue et vision partagée au menu.
La Bibliothèque publique Laure-Conan de La Malbaie
Authors: Pinet Gina
Published: July 2014

L’auteure relate une expérience unique de ravissement et de doute qu’est celle de participer à la construction d’une bibliothèque, de passer d’un dépôt de livres à un espace de vie, de concilier passion et raison, créativité et besoins bibliothéconomiques. Pour réussir le projet, la complicité d’un dialogue constructif entre les partenaires est essentielle.
Le succès du Programme d’aide aux immobilisations : 233 bibliothèques publiques du Québec s’agrandissent de 52 635 m2
Authors: Lacroix Yvon-André
Published: July 2014

De 2001 à 2013, le ministère de la Culture et des Communications a injecté la somme de 148 741 346 $ dans 233 projets de rénovation, d’agrandissement et de construction de bibliothèques publiques au Québec. L’importance financière de son Programme d’aide aux immobilisations a été telle que 52 635 m2 ont ainsi été ajoutés, sans compter les 33 000 m2 de la Grande Bibliothèque (GB). Loin de nuire, celle-ci a même contribué à mettre fin au moratoire des projets de bibliothèques publiques avant l’an 2000 et à relancer leur développement sur l’ensemble du territoire du Québec.
Cinq bibliothèques de Montréal dans la société du savoir : une nouvelle génération de tiers lieux
Authors: Cliche Lucie , Martel Marie D.
Published: July 2014

Cet article présente la première génération de bibliothèques publiques issues du Programme d’agrandissement, de rénovation et de construction (RAC) de la Ville de Montréal. Les conditions visant la réussite de la programmation et la qualité architecturale des projets sont exposées. La vision et les concepts qui structurent ces projets contribuent à l’émergence d’un modèle de bibliothèque tiers lieu novateur à Montréal.
SODA : un nouvel espace « ADOS » à la Bibliothèque municipale de Brossard
Authors: Payette Suzanne
Published: July 2014

L’espace SODA, anagramme du mot ADOS, a été réalisé en janvier 2014 en collaboration avec un designer et la participation des adolescents. Cet espace branché et attractif, décontracté et moderne, polyvalent et sécuritaire, encourage la persévérance scolaire, la créativité et l’épanouissement des adolescents.
La Bibliothèque du Goethe-Institut Montréal : un modèle pour les autres bibliothèques du réseau Goethe
Authors: Poulin Marie-Pierre
Published: July 2014

Le Goethe-Institut Montréal est un institut culturel allemand. Installé à Montréal depuis plus de 50 ans, il a connu trois déménagements au cours de son existence. Ces changements ont chaque fois été effectués afin de répondre aux besoins de sa clientèle et de ses employés. Cet article relate le plus récent de ces déménagements, survenu durant l’été 2012, mais dont les préparatifs ont commencé bien avant cette date.
La Bibliothèque Gilles-Vigneault1 : un espace patrimonial résolument moderne!
Authors: Hardel Frédéric , Saint-Pierre Michel-L.
Published: July 2014

En 2009-2010 a eu lieu un important réaménagement à la Bibliothèque Gilles-Vigneault du Cégep de Rimouski, permettant à la fois une redécouverte de l’ancienne chapelle dans laquelle elle est située, l’intégration de nouveaux services et une mise à jour technologique. Le projet, dont les principales orientations ont été prises de manière collégiale, a notamment mené à la création d’espaces de travail et de socialisation diversifiés très prisés par la clientèle.
Bibliothèques collégiales : quatre exemples d’espaces adaptés au travail individuel et collaboratif
Authors: Marquis Daniel , Haché Nicole , Julien Marc , Lamontagne Nancie
Published: July 2014

Les bibliothèques collégiales diffèrent d’autres institutions par l’importance accordée dans leur mission à l’arrimage avec la réussite scolaire des étudiants. Elles s’imposent comme des lieux dynamiques, favorisant l’accès à l’information, le soutien à la recherche, l’étude individuelle et le travail collaboratif : quatre éléments clés qui se reflètent dans les quatre projets de réaménagement et d’agrandissement majeurs présentés ici. La contribution des bibliothécaires professionnels est sollicitée au début du projet, en produisant un devis technique constitué des éléments de base de la nouvelle bibliothèque. Par la suite, ils sont invités à collaborer aux diverses étapes de réalisation du projet, en ayant en tête l’aménagement d’espaces répondant aux fonctions bibliothéconomiques convenues dans le devis.
Architecture et bibliothèques : conseils d’ami
Authors: Dumont Richard
Published: July 2014

À la fois stimulants et déstabilisants, les projets de construction, d’aménagements ou de réaménagements de bibliothèques trônent parmi mes préférés. J’ai été associé jusqu’ici à trois projets de construction de bibliothèques (École Polytechnique de Montréal, campus de Laval et campus d’Outremont de l’Université de Montréal) sans compter une multitude de projets de réaménagements. Voici, sans prétention, cinq conseils tirés de mon expérience.
Au-delà du programme, l’architecte du bien-être : entrevue avec Manon Asselin
Authors: Beaudry Guylaine , Lacroix Yvon-André
Published: July 2014

Guylaine Beaudry et Yvon-André Lacroix ont rencontré en novembre 2013, pour Documentation et bibliothèques, l’architecte Manon Asselin. Elle a à son actif plusieurs projets de bibliothèques, dont quelques-unes sont des références et des réussites reconnues comme en témoignent les nombreux prix qu’elles ont reçus, notamment le Prix du Gouverneur général 2014 pour la Bibliothèque Raymond-Lévesque. Manon Asselin a cofondé avec son conjoint Katsuhiro Yamazaki l’agence d’architecture Atelier TAG. En plus de sa pratique professionnelle, elle est professeure adjointe à la Faculté d’aménagement de l’Université de Montréal.
Bibliothèques, désormais lieux de tous les possibles
Authors: LeTourneux Jean-Pierre , Archambault Audrey , Hénault Odile
Published: July 2014

Les bibliothèques, longtemps associées à une image traditionnelle, presque pudique, sont aujourd’hui à l’avant-garde de la création architecturale. En effet, la nécessité pour les bibliothécaires de s’adapter au virage virtuel et leur enthousiasme, dans la plupart des cas, face aux nouvelles tendances ont engendré un climat extrêmement favorable à la créativité. Les architectes sont les premiers à en bénéficier. Les concepteurs de la firme Menkès Shooner Dagenais LeTourneux Architectes de Montréal tracent un bref portrait du contexte culturel au sein duquel s’inscrivent trois de leurs réalisations récentes.
Le gestionnaire de projet face aux défis des bibliothèques du XXIe siècle
Authors: Roy Jean
Published: July 2014

Le gestionnaire de projet doit s’adapter à de nombreuses contraintes, dont de nouvelles d’ordre technologique et environnemental. Quatre exemples servent à illustrer cette évolution de son rôle : la Grande Bibliothèque, les Bibliothèques du Boisé et Saul-Bellow de la Ville de Montréal, et la future bibliothèque du site Outremont de l’Université de Montréal.
Le paradoxal troisième lieu, phénix culturel du XXIe siècle
Authors: Plante Jacques
Published: July 2014

Affubler les bibliothèques du XXIe siècle de l’appellation de « troisième lieu », voire de « tiers-lieu », paraîtra réducteur et peu pertinent à quiconque s’attarde à la question. Considérant le renouvellement constant dont elles font preuve à chaque avancée technologique et leur achalandage croissant, ces bibliothèques de l’ère des médias sociaux ont vraiment su se réinventer. La Bibliothèque Jaume Fuster de Barcelone est un merveilleux exemple de l’évolution de ce lieu culturel, qu’il semble préférable de qualifier d’« espace polymorphe ».
Pickup ion measurements by MAVEN: A diagnostic of photochemical oxygen escape from Mars
Authors: Rahmati A. , Cravens T. E. , Nagy A. F. , Fox J. L. , Bougher S. W. , Lillis R. J. , Ledvina S. A. , Larson D. E. , Dunn P. , Croxell J. A.
Published: July 2014

A key process populating the oxygen exosphere at Mars is the dissociative recombination of ionospheric O2+, which produces fast oxygen atoms, some of which have speeds exceeding the escape speed and thus contribute to atmospheric loss. Theoretical studies of this escape process have been carried out and predictions made of the loss rate; however, directly measuring the escaping neutral oxygen is difficult but essential. This paper describes how energetic pickup ion measurements to be made near Mars by the SEP (Solar Energetic Particle) instrument on board the MAVEN (Mars Atmosphere and Volatile EvolutioN) spacecraft can be used to constrain models of photochemical oxygen escape. In certain solar wind conditions, neutral oxygen atoms in the distant Martian exosphere that are ionized and picked up by the solar wind can reach energies high enough to be detected near Mars by SEP.
Effects of Music Training on Attention, Processing Speed and Cognitive Music Abilities—Findings from a Longitudinal Study
Authors: Roden Ingo , Könen Tanja , Bongard Stephan , Frankenberg Emily , Friedrich Esther Kamala , Kreutz Gunter
Published: July 2014

The present study addresses visual attention and processing speed in primary school children (N = 345; 7–8 years of age) who received either music (MC) or natural science training (NC) over a period of 18 months. Dependent variables were collected three times (T1–T3) and included measures for processing speed, visual attention and cognitive music abilities. They were submitted to latent or manifest change models including socioeconomic status and basic cognitive functions as covariates. Groups performed similarly in all dependent tasks at baseline (T1). MC showed significant increases in processing speed as well as in music abilities from T2 to T3 and increases in rhythmic abilities from T1 to T2. Although MC also showed increases in both processing speed and visual attention over time, they were at a small advantage with respect to the former and at a clear disadvantage with respect to the latter measure as compared to NC. Copyright © 2014 John Wiley & Sons, Ltd.
Gated Mesoporous SiO2 Nanoparticles Using K+‐Stabilized G‐Quadruplexes
Authors: Zhang Zhanxia , Wang Fuan , Sohn Yang Sung , Nechushtai Rachel , Willner Itamar
Published: July 2014

The K+‐induced formation of G‐quadruplexes provides a versatile motif to lock or unlock substrates trapped in the pores of mesoporous SiO2 nanoparticles, MP‐SiO2 NPs. In one system, the substrate is locked in the MP‐SiO2 NPs by K+‐ion‐stabilized G‐quadruplex units, and the pores are unlocked by the elimination of K+ ions using Kryptofix [2.2.2] (KP) or 18‐crown‐6‐ether (CE) from the G‐quadruplexes. In the second system, the substrate is locked in the pores by means of K+‐stabilized aptameric G‐quadruplex/thrombin units. Unlocking of the pores is triggered by the dissociation of the aptamer/thrombin complexes through the KP‐ or CE‐mediated elimination of the stabilizing K+ ions. In the third system, duplex DNA units lock the pores of MP‐SiO2 NPs, and the release of the entrapped substrate is stimulated by the K+‐ion‐induced dissociation of the duplex caps through the formation of the K+‐stabilized G‐quadruplexes. The latter system is further implemented to release the anti‐cancer drug, doxorubicin, in the presence of K+ ions, from the MP‐SiO2 NPs. Preliminary intracellular experiments reveal that doxorubicin‐loaded MP‐SiO2 NPs lead to effective death of breast cancer cells.
Prenatal and postnatal findings in serpentine fibula polycystic kidney syndrome and a review of the NOTCH2 spectrum disorders
Authors: Martin Brett M. , Ivanova Margarita H. , Sarukhanov Anna , Kim Ashley , Power Patricia , Pugash Denise , Popescu Oana‐Eugenia , Lachman Ralph S. , Krakow Deborah , Patel Millan S.
Published: July 2014

Serpentine fibula polycystic kidney syndrome (SFPKS; OMIM600330) is a rare skeletal dysplasia with a characteristic phenotype that includes polycystic kidneys, S‐shaped fibulas, and abnormal craniofacial features. SFPKS shares features with Alagille (AGS; OMIM) and Hajdu–Cheney (HCS; OMIM10250) syndromes. All three syndromes result from mutations in the gene that encodes NOTCH2, one of the receptors involved in Notch signaling. Notch signaling is a major developmental signaling pathway, as well as a key regulator of numerous cellular processes. In this report, we present the prenatal ultrasound and postnatal findings in a 23‐week fetus with severe manifestations of SPKS and heterozygosity for a de novo mutation in exon 34 of NOTCH2. These findings expand the phenotypic spectrum of NOTCH2 mutations and demonstrate the findings in the prenatal period. © 2014 Wiley Periodicals, Inc.
Toughening of epoxy resin with functionalized core‐sheath structured PAN/SBS electrospun fibers
Authors: Guo Tanghua , Zhou Zhi , Guo Honglei , Xiao Guohua , Tang Xinglei , Peng Mao
Published: July 2014

Core‐sheath structured electrospun fibers with styrene‐butadiene‐styrene (SBS) block copolymer as a rubbery core and polyacrylonitrile (PAN) as a hard sheath were prepared by coaxial electrospinning, and used to improve the toughness of epoxy resin. The surface of the fibers was aminated by reacting PAN with diethylenetriamine to improve the interfacial interaction between the fibers and epoxy. Scanning and transmission electron microscopies confirm the core‐sheath structure of the PAN/SBS fibers. The Charpy impact energy is increased by the addition of electrospun fibers. When the content of aminated core‐sheath fibers is 4 wt %, the Charpy impact energy is increased by 150%. Dynamic mechanical analysis shows that the glass transition temperature of epoxy is not decreased by the addition of core‐sheath fibers. The high impact resistance is attributed to the rubbery core of the fibers that can absorb and dissipate impact energy, and the chemical bonding between the fibers and epoxy. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41119.
Terpolymers as precursors for CuO nanoparticles synthesis
Authors: Zoromba M. Sh. , Al‐Hussaini A. S.
Published: July 2014

This work describes the synthesis of terpolymers of aniline, diphenylamine, and o‐anthranilic acid (PANIDPAA) by 1 : 1 : 1 molar ratio of the respective monomers doped by different concentration of copper ions via in situ chemical terpolymerization. The results are justified by measuring spectral characteristics namely, UV‐vis absorption spectra, FTIR, and TGA. Calcining these PANIDPAA terpolymers doped by copper at temperatures in the range of 700°C led to the formation of CuO nanoparticles in the nanoscale by thermal decomposition in air directly. The stages of decompositions and the calcination temperature of the precursors have been determined from thermal analysis data sheet. The obtained CuO nanoparticles have been characterized by X‐ray diffraction and transmission electron microscope (TEM). TEM showed a particle size less than 40 nm. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41150.
Renewable thermoset copolymers from tung oil and natural terpenes
Authors: Sibaja Bernal , Sargent Jessica , Auad Maria L.
Published: July 2014

The cationic copolymerization of tung oil, limonene, and myrcene as comonomers, initiated by boron trifluoride, is presented and discussed in this work. Dynamic mechanical analysis revealed that all copolymers behave as thermosets. FTIR spectra for both copolymers, after extraction with dichloromethane, suggested that the major component of the insoluble fraction was reacted tung oil (a cross‐linked triglyceride network). Likewise, unreacted tung oil was found to be the main component of the soluble phase. Also, all the copolymers showed only one tan δ peak, indicating no phase separation. Glass transition temperature (Tg) increased with the myrcene content and decreased almost linearly as the limonene content increased. Furthermore, the Fox and Loshaek model showed a relatively good prediction of the Tg values of the polymers. The Young's modulus ranged from 33.8 to 4.7 MPa for all tested thermosets. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2014,131, 41155.
Importance of crosslinking and disulfide bridge reduction for the mechanical properties of rigid wheat gluten bioplastics compression molded with thiol and/or disulfide functionalized additives
Authors: Jansens Koen J. A. , Bruyninckx Kevin , Redant Lore , Lagrain Bert , Brijs Kristof , Goderis Bart , Smet Mario , Delcour Jan A.
Published: July 2014

Thiol (SH) containing additives improve the mechanical properties of rigid, glassy gluten materials. However, the underlying molecular mechanism is still unclear. In particular, the importance of the preceding gluten‐additive mixing conditions remains to be investigated. Here, different additives containing either only SH, only disulfide or both SH and disulfide functionalities were synthesized and their impact on the gluten network using different mixing conditions prior to subsequent molding were assessed. All SH containing additives decreased the gluten molecular weight (MW) during mixing to a degree depending on the conditions. Additives with only disulfide functionality did not significantly affect protein size during mixing irrespective of the conditions used. Only when mixing induced sufficient MW reduction did the strength and failure strain of rigid gluten materials increase. This shows that factors other than the degree of cross‐linking affect the strength of rigid gluten materials. These results support our hypothesis that altered molecular conformations and improved molecular entanglements contribute to material strength. The extent to which such conformational changes occur may depend on the additive and the way of mixing. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41160.
Stability of acrylic acid grafted poly(vinylidene fluoride) hollow fiber membrane prepared by high‐energy electron beam
Authors: Kong Zhiyun , Wei Junfu , Yang Liang , Luo Zian , Zhao Kongyin , Wang Xiaolei
Published: July 2014

In this article, poly(vinylidene fluoride) (PVDF) hollow fiber membrane and acrylic acid (AA) were co‐irradiated by high‐energy electron beam to introduce hydrophilic carboxylic groups on the membrane surface. Thermal capability, mechanical performance, pore size, and permeation property were investigated to determine the stability of the membrane pore structure before and after irradiation polymerization. The decomposition temperature, melting point, glass transition temperature, and breaking force of the PVDF‐g‐AA membrane increased slightly because of irradiation grafting polymerization. After 15 months of storage, the pore size distribution of the PVDF‐g‐AA membrane became smaller and more dispersive. The pure water flux and the rejection to bovine serum albumin of the PVDF‐g‐AA membrane increased significantly with the increase in hydrophilicity and decrease in pore size. The results indicated that the structure and properties of the PVDF hollow fiber membrane were stable after high‐energy electron beam irradiation grafting polymerization, even after 15 months of storage. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41165.
Three‐Dimensional Study of the Facial Canal Using Microcomputed Tomography for Improved Anatomical Comprehension
Authors: Shin Kang‐Jae , Gil Young‐Chun , Lee Ju‐Young , Kim Jeong‐Nam , Song Wu‐Chul , Koh Ki‐Seok
Published: July 2014

The aims of this study were to determine the various dimensions of the normal facial canal and to identify the spatial relationships between the facial canal and its adjacent structures using microcomputed tomography (micro‐CT) imaging and three‐dimensional (3D) reconstruction. The petrous parts of 54 temporal bones were scanned using micro‐CT with a slice thickness of 35 μm. The serial micro‐CT images were used to reconstruct 3D volumes of the facial canal and the bony labyrinth with the aid of computer software. These volumes were used to measure 31 dimensions of the facial canal and its spatial relationships with adjacent structures. The length of the meatal segment, the tympanic segment, and the mastoid segment were significantly larger in males than in females (p < 0.05). The narrowest portions of the facial canal were immediately lateral to the meatal foramen in the labyrinthine segment and the midpoint of the tympanic segment. The distance between the origin of the canal for the chorda tympani nerve and midpoint of the stylomastoid foramen was 35.3% of the length of the mastoid segment, and the angle between the tympanic segment and the lateral semicircular canal was 16.3°. The angle between the mastoid segment and the canal for the chorda tympani nerve could be classified into two groups: <180° and >180°. These findings represent supplemental data for improving the detailed understanding of the facial canal anatomy. Anat Rec, 297:1808–1816, 2014. © 2014 Wiley Periodicals, Inc.
A pilot study comparing the use of Thiel‐ and formalin‐embalmed cadavers in the teaching of human anatomy
Authors: Balta Joy Y. , Lamb Clare , Soames Roger W.
Published: July 2014

Formalin had traditionally been used to preserve human material to teach gross anatomy. In 2008 the Centre for Anatomy and Human Identification (CAHID) at the University of Dundee embarked on the use of the Thiel method of embalming. The aim of this pilot study was to assess the difference between formalin‐embalmed cadavers (FEC) and Thiel‐embalmed cadavers (TEC) used for teaching and surgical training. Three different questionnaires were prepared for data collection from undergraduate and postgraduate students and clinical staff. All undergraduate and postgraduate students as well as clinical staff commented on the appearance of the TEC. There was no overall consensus concerning the use of TEC, some respondents preferred TEC for the entire dissection, some only for certain areas such as the musculoskeletal system. On a technical level TEC were considered less hazardous then FEC by one‐third of participants with fewer than 10% regarding TEC as more irritating than FEC. Psychologically, 32.7% of undergraduate students expressed the view that TEC made them feel more uncomfortable compared with FEC because of their life‐like appearance. However, 57.1% of undergraduate students encountered the same uncomfortable feelings when viewing both TEC and FEC. The use of Thiel‐embalmed cadavers to teach anatomy has an added value, though further research is required over longer periods of time to identify its best usage. Anat Sci Educ 8: 86–91. © 2014 American Association of Anatomists.
Human structure in six and one‐half weeks: One approach to providing foundational anatomical competency in an era of compressed medical school anatomy curricula
Authors: Halliday Nancy , O'Donoghue Daniel , Klump Kathryn E. , Thompson Britta
Published: July 2014

The University of Oklahoma College of Medicine reduced gross anatomy from a full semester, 130‐hour course to a six and one‐half week, 105‐hour course as part of a new integrated systems‐based pre‐clinical curriculum. In addition to the reduction in contact hours, content from embryology, histology, and radiology were added into the course. The new curriculum incorporated best practices in the area of regular assessments, feedback, clinical application, multiple teaching modalities, and professionalism. A comparison of the components of the traditional and integrated curriculum, along with end of course evaluations and student performance revealed that the new curriculum was just as effective, if not more effective. This article also provides important lessons learned. Anat Sci Educ 8: 149–157. © 2014 The Authors. Published by Wiley Periodicals, Inc. on behalf of the American Association of Anatomists.
Stabilization of Human Telomeric G‐Quadruplex and Inhibition of Telomerase Activity by Propeller‐Shaped Trinuclear PtII Complexes
Authors: Xu Cui‐Xia , Shen Yong , Hu Qian , Zheng Yu‐Xuan , Cao Qian , Qin Peter Z. , Zhao Yong , Ji Liang‐Nian , Mao Zong‐Wan
Published: July 2014

Two novel propeller‐shaped, trigeminal‐ligand‐containing, flexible trinuclear PtII complexes, {[Pt(dien)]3(ptp)}(NO3)6 (1) and {[Pt(dpa)]3(ptp)}(NO3)6 (2) (dien: diethylenetriamine; dpa: bis‐(2‐pyridylmethyl)amine; ptp: 6′‐(pyridin‐3‐yl)‐3,2′:4′,3′′‐terpyridine), have been designed and synthesized, and their interactions with G‐quadruplex (G4) sequences are characterized. A combination of biophysical and biochemical assays reveals that both PtII complexes exhibit higher affinity for human telomeric (hTel) and c‐myc promoter G4 sequences than duplex DNA. Complex 1 binds and stabilizes hTel G4 sequence more effectively than complex 2. Both complexes are found to induce and stabilize either antiparallel or parallel conformation of G4 structures. Molecular docking studies indicate that complex 1 binds into the large groove of the antiparallel hTel G4 structure (PDB ID: 143D) and complex 2 stacks onto the exposed G‐quartet of the parallel hTel G4 structure (PDB ID: 1KF1). Telomeric repeat amplification protocol assays demonstrate that both complexes are good telomerase inhibitors, with IC50 values of (16.0±0.4) μM and (4.20±0.25) μM for 1 and 2, respectively. Collectively, the results suggest that these propeller‐shaped flexible trinuclear PtII complexes are effective and selective G4 binders and good telomerase inhibitors. This work provides valuable information for the interaction between multinuclear metal complexes with G4 DNA.
Direct Silica Encapsulation of Self‐Assembled‐Monolayer‐Based Surface‐Enhanced Raman Scattering Labels with Complete Surface Coverage of Raman Reporters by Noncovalently Bound Silane Precursors
Authors: Schütz Max , Salehi Mohammad , Schlücker Sebastian
Published: July 2014

Silica‐coated surface‐enhanced Raman scattering (SERS) labels with a self‐assembled monolayer (SAM) on the entire surface of the metal colloid combine high chemical and mechanical stability with bright and reproducible Raman signals due to the complete surface coverage and uniform molecular orientation within the SAM. Currently available chemical syntheses are either based on the direct encapsulation of covalently bound silane precursors or comprise several steps, such as the sequential addition of noncovalently bound polyelectrolytes to render the surface vitreophilic. Here, a generic approach for the direct and fast silica encapsulation of commercially available Raman reporter molecules with polar head groups by noncovalently bound silane precursors is reported. The formation of highly SERS‐active silica‐coated clusters during silica encapsulation is determined by several parameters, in particular the type of Raman reporter molecule, the solvent, and the type and amount of the silane precursor.
Classification modeling approach for vehicle dynamics model‐integrated traffic simulation assessing surrogate safety
Authors: So Jaehyun (Jason) , Park Byungkyu (Brian) , Yun Ilsoo
Published: July 2014

To assess safety impacts of untried traffic control strategies, an earlier study developed a vehicle dynamics model‐integrated (i.e., VISSIM‐CarSim‐SSAM) simulation approach and evaluated its performance using surrogate safety measures. Although the study found that the integrated simulation approach was a superior alternative to existing approaches in assessing surrogate safety, the computation time required for the implementation of the integrated simulation approach prevents it from using it in practice. Thus, this study developed and evaluated two types of models that could replace the integrated simulation approach with much faster computation time, feasible for real‐time implementation. The two models are as follows: (i) a statistical model (i.e., logit model) and (ii) a nonparametric approach (i.e., artificial neural network). The logit model and the neural network model were developed and trained on the basis of three simulation data sets obtained from the VISSIM‐CarSim‐SSAM integrated simulation approach, and their performances were compared in terms of the prediction accuracy. These two models were evaluated using six new simulation data sets. The results indicated that the neural network approach showing 97.7% prediction accuracy was superior to the logit model with 85.9% prediction accuracy. In addition, the correlation analysis results between the traffic conflicts obtained from the neural network approach and the actual traffic crash data collected in the field indicated a statistically significant relationship (i.e., 0.68 correlation coefficient) between them. This correlation strength is higher than that of the VISSIM only (i.e., the state of practice) simulation approach. The study results indicated that the neural network approach is not only a time‐efficient way to implementing the VISSIM‐CarSim‐SSAM integrated simulation but also a superior alternative in assessing surrogate safety. Copyright © 2014 John Wiley & Sons, Ltd.
A label‐free DNAzyme‐cleaving fluorescence method for the determination of trace Pb2+ based on catalysis of AuPd nanoalloy on the reduction of rhodamine 6G
Authors: Tang Meiling , Wen Guiqing , Luo Yanghe , Kang Caiyan , Liang Aihui , Jiang Zhiliang
Published: July 2014

The substrate chain of double‐stranded DNA (dsDNA) could be specifically cleaved by Pb2+ to release single‐stranded DNA (ssDNA) that adsorbs onto the AuPd nanoalloy (AuPdNP) to form a stable AuPdNP–ssDNA complex, but the dsDNA can not protect AuPdNPs in large AuPdNP aggregates (AuPdNPA) under the action of NaCl. AuPdNP–ssDNA and large AuPdNPA could be separated by centrifugation. On increasing the concentration of Pb2+, the amount of released ssDNA increased; AuPdNP–ssDNA increased in the centrifugation solution exhibiting a catalytic effect on the slow reaction of rhodamine 6G (Rh6G) and NaH2PO2, which led to fluorescence quenching at 552 nm. The decrease in fluorescence intensity (ΔF) was linear to the concentration of Pb2+ within the range 0.33–8.00 nmol/L, with a detection limit of 0.21 nmol/L. The proposed method was applied to detect Pb2+ in water samples, with satisfactory results. Copyright © 2014 John Wiley & Sons, Ltd.
Insight into the neurophysiological processes of melodically intoned language with functional MRI
Authors: Méndez Orellana Carolina P. , van de Sandt‐Koenderman Mieke E. , Saliasi Emi , van der Meulen Ineke , Klip Simone , van der Lugt Aad , Smits Marion
Published: July 2014

Background

Melodic Intonation Therapy (MIT) uses the melodic elements of speech to improve language production in severe nonfluent aphasia. A crucial element of MIT is the melodically intoned auditory input: the patient listens to the therapist singing a target utterance. Such input of melodically intoned language facilitates production, whereas auditory input of spoken language does not.

Methods

Using a sparse sampling fMRI sequence, we examined the differential auditory processing of spoken and melodically intoned language. Nineteen right‐handed healthy volunteers performed an auditory lexical decision task in an event related design consisting of spoken and melodically intoned meaningful and meaningless items. The control conditions consisted of neutral utterances, either melodically intoned or spoken.

Results

Irrespective of whether the items were normally spoken or melodically intoned, meaningful items showed greater activation in the supramarginal gyrus and inferior parietal lobule, predominantly in the left hemisphere. Melodically intoned language activated both temporal lobes rather symmetrically, as well as the right frontal lobe cortices, indicating that these regions are engaged in the acoustic complexity of melodically intoned stimuli. Compared to spoken language, melodically intoned language activated sensory motor regions and articulatory language networks in the left hemisphere, but only when meaningful language was used.

Discussion

Our results suggest that the facilitatory effect of MIT may – in part – depend on an auditory input which combines melody and meaning.

Conclusion

Combined melody and meaning provide a sound basis for the further investigation of melodic language processing in aphasic patients, and eventually the neurophysiological processes underlying MIT.
Combining the pan‐aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
Authors: Paller Channing J. , Wissing Michel D. , Mendonca Janet , Sharma Anup , Kim Eugene , Kim Hea‐Soo , Kortenhorst Madeleine S. Q. , Gerber Stephanie , Rosen Marc , Shaikh Faraz , Zahurak Marianna L. , Rudek Michelle A. , Hammers Hans , Rudin Charles M. , Carducci Michael A. , Kachhap Sushant K.
Published: July 2014

Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies have focused on the reexpression of silenced tumor suppressor genes, a number of genes/pathways are downregulated by HDACIs. This provides opportunities for combination therapy: agents that further disable these pathways through inhibition of residual gene function are speculated to enhance cell death in combination with HDACIs. A previous study from our group indicated that mitotic checkpoint kinases such as PLK1 and Aurora A are downregulated by HDACIs. We used in vitro and in vivo xenograft models of prostate cancer (PCA) to test whether combination of HDACIs with the pan‐aurora kinase inhibitor AMG 900 can synergistically or additively kill PCA cells. AMG 900 and HDACIs synergistically decreased cell proliferation activity and clonogenic survival in DU‐145, LNCaP, and PC3 PCA cell lines compared to single‐agent treatment. Cellular senescence, polyploidy, and apoptosis was significantly increased in all cell lines after combination treatment. In vivo xenograft studies indicated decreased tumor growth and decreased aurora B kinase activity in mice treated with low‐dose AMG 900 and vorinostat compared to either agent alone. Pharmacodynamics was assessed by scoring for phosphorylated histone H3 through immunofluorescence. Our results indicate that combination treatment with low doses of AMG 900 and HDACIs could be a promising therapy for future clinical trials against PCA.
Prevention of Solvent‐Mediated Isomer Transfer of Carotenoids
Authors: Kreißig Franziska , Schäfer Christian , Ulrich Joachim
Published: July 2014

During industrial manufacturing, formulation, and storage, the tendency towards isomerization of astaxanthin (AXT) may affect its bioavailability. Potential additives like potassium carbonate, potassium acetate, dipotassium hydrogen orthophosphate, potassium hydroxide, and cesium carbonate were mixed to solutions of AXT and chloroform in order to increase the stability of all‐trans AXT while present in solution. The additives should not cause any damage to neither the dissolved nor the crystalline substance. Concentration changes in the course of time were measured and monitored by HPLC and a photometer. The additives exerted different effects on the dissolved AXT, either enhancing or weakening the isomerization processes and/or decomposition. Potassium carbonate and dipotassium hydrogen orthophosphate insufficiently affected the preservation of the all‐trans AXT structure. In contrast, potassium acetate, potassium hydroxide, and cesium carbonate led to satisfying results and can be recommended as additives.