bluuebunny/crossref_metadata_2025 huggingface dataset:
Quasiperiodic Variations of Coronal Mass Ejections with Different Angular Widths
Authors: Li Xia , Deng Hui , Wang Feng , Deng Linhua , Mei Ying
Published: February 2023

Coronal mass ejections (CMEs) are energetic expulsions of organized magnetic features from the Sun. The study of CME quasiperiodicity helps establish a possible relationship between CMEs, solar flares, and geomagnetic disturbances. We used the angular width of CMEs as a criterion for classifying the CMEs in the study. Based on 25 yr of observational data, we systematically analyzed the quasiperiodic variations corresponding to the CME occurrence rate of different angular widths in the northern and southern hemispheres, using frequency and time–frequency analysis methods. There are various periods for CMEs of different angular widths: 9 months, 1.7 yr, and 3.3–4.3 yr. Compared with previous studies based on the occurrence rate of CMEs, we obtained the same periods of 1.2 (±0.01), 3.1 (±0.04), and ≈6.1 (±0.4) months, and 1.2 (±0.1) and 2.4 (±0.4) yr. We also found additional periods of all CMEs that appear only in one hemisphere or during a specific solar cycle. For example, 7.1 (±0.2) months and 4.1 (±0.2) yr in the northern hemisphere, 1 (±0.004) and 5.9 (±0.2) months and 1 (±0.1), 1.4 (±0.1), and 2.4 (±0.4) yr in the southern hemisphere, 6.1 (±0.4) months in solar cycle 23, and 6.1 (±0.4) months and 1.2 (±0.1) and 3.7 (±0.2) yr in solar cycle 24. The analysis shows that quasiperiodic variations of the CMEs are a link among oscillations in coronal magnetic activity, solar flare eruptions, and interplanetary space.
Knowledge and perceptions of patients towards generic and local medications: The lebanese version
Authors: Mehtar Amani , Gazy Azza , Al Jamal Marwa , Saab May
Published: February 2023

Lebanon is one of the Mediterranean countries that are devastated by economic crisis. Knowing that generic medications are less costly when compared to brands, it is crucial to assess patients’ understanding and views regarding these medications.

A 25-item self-administered anonymous questionnaire was distributed to a total of 421 participants. The questionnaire appraised participants’ knowledge and perceptions about generics versus brand medications, in addition to their perceptions and attitudes towards generic substitution. Most respondents agreed that generics are not inferior to their brand equivalents in terms of quality, efficacy and safety (66%, 68.9%, and 66.7%, respectively). On the other hand, 79.4% (n=334) accepted generic substitution for minor ailment medications, whereas, only 56.1% (n=236) accepted this substitution for their chronic medications. As a conclusion, the uncertainty about the use of generic medications, particularly those treating chronic illness is still an obstacle to overcome.
Positive solutions for fractional iterative functional differential equation with a convection term
Authors: Song Qingcong , Hao Xinan
Published: February 2023

In this paper, we deal with the fractional iterative functional differential equation nonlocal boundary value problem with a convection term. By using the fixed point theorems, some results about existence, uniqueness, continuous dependence and multiplicity of positive solutions are derived.
Identification of new cases of tuberculosis during the COVID-19 pandemic using model strategic management
Authors: Setiyowati Eppy , Hanik Umi , Juliasih Ni Njoman , Susilo Priyo
Published: February 2023

Introduction: Tuberculosis (TB) is a world health problem that causes the third-largest death after cardiovascular and respiratory diseases. One of the causes of transmission of environmental factors is controlling the mobilization of individuals suffering from tuberculosis. This research aims to develop a strategic model of finding new TB cases based on region.

Method: This descriptive research utilizes primary and secondary data. Variables consist of geographical and demographic characteristics, resources, tuberculosis prevalence, and indicators of tuberculosis response processes. The TB management planning model document is based on the experiences of health centers Perak Timur, Wonokromo, and Siwalankerto in maximizing TB case detection.

Results: The management model outlines policies and procedures based on the variables. For example, the detection of new TB patients became a priority at the health center in Perak Timur. In contrast, the health center in Wonokromo focused on developing cadres and private practice physicians.

Conclusions: This research provides an overview of the aspects that need attention and improvement by discovering different new cases in each region.
Correlation of leg pain responses with ankle-brachial index and peripheral sensory responses in foot of type 2 diabetes mellitus
Authors: Kristianto Heri , Nasution Tina Handayani , Fatma Endah Panca Lidya , Sari Efris Kartika , Wibisono Ahmad Hasyim , Kurniawan Haryadi , Ratna Firdausy , Cristiningtyas Ica , Listyowati Endang
Published: February 2023

Introduction: Type 2 Diabetes Mellitus (T2DM) is associated with changes that occur in the peripheral circulation that affect foot functions. Therefore, there is a need for a risk prediction test on foot abnormalities using the leg pain response parameters in T2DM patients with ankle-brachial index (ABI) and peripheral sensory changes as a preventive effort to manage foot care.

Design and Methods: This study employed a cross-sectional design in which 63 T2DM patients in a Public Health Center (PHC) in Malang were investigated. The instruments used include visual analog scale (VAS), monofilament, and foot doppler.

Results: The Pearson correlation test showed no relationship between the responses to leg pain and the ABI of the right and left feet (p-values = 0.217 and 0.692), but there was a significant relationship between the left foot ABI and sensory status (p-value 0.002; left foot r = 0.383). Meanwhile, the Pearson's correlation and linear regression test also showed a relationship between the right foot ABI and sensory status (p-value = 0.007; r = 0.338). Furthermore, a multiple linear regression test showed a relationship between the leg pain response and sensory perception of the right and left feet (p-value = 0.035; r = 0.325).

Conclusions: The relationship between the sensory status of the right and left feet and the response to leg pain in T2DM patients were moderate with a negative direction. It, therefore, implies that a decrease in the sensory responses increased the leg pain. Meanwhile, the moderate relationship and positive direction between the ABI and sensory status of the feet of T2DM patients indicates that a higher ABI score led to an increase in the sensory status of the foot.
The use of web-based digital media to enhance admission orientation for patients in the hospital
Authors: Rahmawati Ike Nesdia , Monitasari Imeldha , Putri Debby Hamsa , Arizda Delfira , Pricila Febry , Rosyidawati Fitri , Sejati Bagus Lanang
Published: February 2023

Introduction: Newly hospitalized patients often face some situations that have not been recognized or faced previously. Meanwhile, admission orientation can help inpatients to adapt and reduce their anxiety, but it has not been carried out optimally in some hospitals in Indonesia. Therefore, innovative media is needed to improve the efficiency and increase the willingness of nurses in carrying out admission orientation.

Objective: This study aims to identify the effect of implementing website-based digital media about admission orientation on nurses' compliance with the procedure for new patient admissions.

Design and Method: This is a quantitative study with a pre-experimental one-group pretest-posttest design. The sample population consists of nurses in the inpatient ward, and a total of 21 samples were then selected using the total sampling method. Subsequently, statistical analysis was carried out on the data obtained using the paired t-test.

Results: The results showed that the p-value was 0.001 (< 0.05), indicating there was a significant difference between the nurse compliance level before and after implementing the web-based digital media. Furthermore, the average pretest score was 90, while the average posttest score was 94.6.

Conclusions: Based on the results, there was an increase in the level of nurse compliance after the intervention.
A cross-sectional study of the knowledge, skills, and 6 rights on medication administration by nurses at emergency department
Authors: Noviyanti Linda Wieke , Junianto Andri , Ahsan Ahsan
Published: February 2023

Introduction: Medication errors occur when a patient is given the wrong drug or receives incorrect pharmacological therapy. Incorrect drug administration can cause fatal errors resulting in the patient’s death. Approximately 44,000-98,000 patients die each year due to medication errors and this condition is found often in the Emergency Room (ER) due to the complexity. Therefore, this study aims to analyze the relationship between nurses’ knowledge, skills, and 6 rights on medication at Emergency Department.

Design and Methods: This is an analytical observational study involving 70 nurses randomly selected using consecutive sampling and working at the ER department of Saiful Anwar Hospital Malang. Data were collected through a questionnaire and analyzed descriptively to determine the knowledge and skills of nurses and the implementation of the correct principles of medication administration.

Results: The results showed that most of the emergency room nurses had good knowledge and skills in applying the correct principles of medicine. However, the majority could not calculate the drug dose accurately. The spearman rank results showed that there was a relationship between knowledge and the 6 correct drug principles (p<0.001, α= 0,05; r = 0.491) with a percentage of 44%. This indicates that a higher knowledge results in the correct implementation of the drug. Similarly, there was a significant positive correlation between skills and proper medicine (p<0.001, α= 0,05; r = 0.378).

Conclusions: It can be inferred that a higher nurse’s knowledge and skill results in a better administration of medicine.
Knowledge and peer support for increase Menstrual Hygiene Management (MHM) in adolescents
Authors: Armini Ni Ketut Alit , Setyani Arik , Nastiti Aria Aulia , Triharini Mira
Published: February 2023

Introduction: During the transitional period of reproductive function development, adolescents require special attention, one of which is menstrual hygiene management (MHM). Teenagers dealing with menstruation have little information and understanding due to the taboo assumption of being more comfortable communicating with peers. Therefore, this study aims to explain the relationship between knowledge and peer support with MHM in adolescent girls.

Design and Methods: This study adopted a correlational descriptive design with a cross-sectional approach and 122 students in apublic Junior High School in East Java were selected using proportional simple random sampling. Furthermore, the questionnaire was adopted as the study instrument to measure the variables of knowledge level, peer support, and MHM. Data were then analyzed using Spearman Rho Test with a significance level of p<0.005.

Results: The results showed that there is a significant relationship between the level of knowledge (p = 0.000 r = 0.619 and peer support (p = 0.000 r = 0.534) with MHM in adolescent girls.

Conclusions: Adolescent girls with adequate knowledge and peer support have better MHM. Therefore, information and education about MHM are recommended for adolescents.
Family health task implementation and the health status of diabetes mellitus patients: A correlational study
Authors: Kristianingrum Niko Dima Kristianingrum , Arizda Delfira , Setyoadi Setyoadi , Hayati Yati Sri , Parchman Michael Leo
Published: February 2023

Introduction: Chronic conditions due to diabetes cause changes in patients’ health status and their family has importantroles in the health care. Therefore, this study aimed to analyze the relationship between family health task implementation and the health status of diabetics.

Design and methods: An observational analytic design with a cross-sectional approach was used, while the respondents consisted of 327 family caregivers and 327 diabetes mellitus patients. This study used both family health task implementation and Short Form Health Survey (SF-12) questionnaires.

Results: The result of the Pearson Product Moment test showed a correlation coefficient of 0.593 and a 0.000 p-value (α 0.05).

Conclusions: It was concluded that there was a fairly strong relationship between family health task implementation and the health status of diabetes mellitus patients. Nursing intervention is needed to improve the implementation of family health tasks.
Experience of nurses using the basic nursing science in performing nursing care for patients at RSUD Dr. Soedomo Trenggalek, Indonesia
Authors: Ardyansah Rizki Bahtiyar , Wisnasari Shila , Wihastuti Titin Andri , Ismail Dina Dewi Sartika Lestari
Published: February 2023

Introduction: The provision of humanistic and professional nursing care services needs to be carried out comprehensively, and it must cover patients’ bio-psycho-socio-spiritual aspects. This indicates nurses have to integrate all the basic nursing science, including physiology, anatomy, pharmacology, and pathophysiology, while carrying out their duties. This integration helps to provide the best care for their patients, but they often uncertain about the basic science approach to use. Therefore, this study aimsto explore the experience of nurses using basic nursing science in caring for patients with chronic diseases.

Design and Methods: In-depth interviews were conducted with 5 nurses working in chronic disease wards for at least 5 years. Each respondent was then interviewed using a self-constructed questionnaire.

Results: All respondents agreed that basic nursing science is important in providing quality healthcare services. Furthermore, six themes were identified using the thematic analysis, namely (1) the process of collecting patient data, which was more focused and organized; (2) required for establishing the nursing diagnosis; (3) useful for determining the nursing care plan; (4) it is a basis for implementing nursing actions; (5) provides a basis for monitoring and follow-up; (6) and teamwork between health personnel is more effective.

Conclusions: Based on the interview results, nurses need knowledge and skills in basic nursing science while caring for patients with chronic diseases. Furthermore, basic nursing sciences lay the foundation for nurses while assessing patients, diagnosing, planning the care, implementing nursing actions, evaluating patients’ condition, and collaborating with other health personnel.
Modeling, analysis and optimization of the rear axle of cereal combine harvester under real loads using finite elements method
Authors: Rezaei Azam , Masoudi Hassan , Zaki Dizaji Hassan , Khorasani Ferdavani Mohamad Esmail
Published: February 2023

Cereals combine harvester is one of the agricultural machines that works in difficult conditions and different forces are applied to its parts. The purpose of this study was to analyze static and dynamic loads on the rear axle of JD955 combine harvester to optimize it. First, real loads on the axle were measured by a special electronic system in stationary and moving modes in roads and farm with various forward speeds. Then, geometric model of the axle was designed in the CATIA software. Finally static, harmonic, transient and dynamic analysis were performed using finite element method in the ANSYS Workbench software. Mean of maximum loads on the axle in stopped mode, asphalt road, dirt road and inside the farm (while moving parallel and perpendicular to the farrows and turning in farm end) were equal to 15.067, 18.830, 49.167, 21.428, 27.07 and 27.857 KN, respectively. There was relatively linear relationship between the axle load and deformation. At the maximum load of 49.167 KN, the maximum von Mises stresses of 1200, 85.848, 21.392 and 1.754e-14 MPa were obtained in static, transient, dynamic and harmonic analyzes, respectively. Since structural errors in the axle were numerically close to zero, so the calculated stress values had good accuracy. The axle fatigue life for most of the loads was equal to the ideal value of 106 cycles. The least fatigue safety factor were obtained from 0.072 to 0.745 in static analysis and from 0.174 to 1.029 in linear transient analysis. According to the results of the analysis, it was necessary to optimize the existing design of axle. So, a rectangular piece was suggested as the suitable design for the JD955 rear axle middle section.
Effects of Innovation on Business Performance: Empirical Evidence from Manufacturing Firms in Tanzania
Authors: Mwaifyusi Hussein Athumani , Dau Ramadhani Kitwana
Published: February 2023

Regardless of its relevance for business performance, the influence of innovation on the performance of manufacturing firms in Tanzania is not well  documented. Thus, this study aimed to examine the effects of innovation on business performance of manufacturing firms in Tanzania. The study used  cross-sectional design and quantitative approach. Copies of a structured questionnaire were administered to 420 participants from 28 manufacturing  companies in Dar es Salaam and Coast Regions. An impressive response rate of 93.1% was achieved. Data were tested for reliability using Cronbach’s  alpha coefficient. Tests for normality, multicollinearity and autocorrelation were conducted, and the results showed the data were reliable, normally  distributed, free of multicollinearity and autocorrelation problems. Descriptive and multiple regression statistical techniques were employed. The results  suggested that a significant positive effect existed between performance of manufacturing firms and product innovation (B=0.705, p=0.001), process  innovation (B=0.640, p=0.000) and marketing innovation (B=.818, p=0.000). The obvious implication to industry is that innovation is important to business  success of the manufacturing companies, thus the governments should motivate firms to innovate continuously by giving incentives to invest in R&D.  Past studies linking innovation and performance have focused on financial measures of performance. The major contribution of the current study is to  use non-financial measures of performance such as business growth and responsiveness to change.
Procurement Contract Management and Procurement Performance in Parastatal Organisations in Tanzania
Authors: Masoud Y. , Emmanuel T. , Salum M.
Published: February 2023

Despite a lot of initiatives being undertaken by the United Republic of Tanzania to improve public procurement, the performance of many of the  contracted projects is not satisfactory since a significant amount of public money is lost through procurement contract management. The aim of this  study was to determine the role of procurement contract management in Tanzania's parastatal entities. The study examined the impact of contract  preparation, the competence of the contract management team, and the contract allocated budget on procurement performance and made  recommendations for improving it. The study used a quantitative approach with an explanatory research design whereby data were collected by using a  close-ended questionnaire. Simple random sampling technique was used to select 241 respondents who were heads of departments from the 93  parastatal organizations. The data were analysed descriptively by computing descriptive statistics and inferentially using a multiple regression model. The  findings indicated that contract preparation, competence of contract management teams, and contract allocated budget had significant positive  relationships with procurement performance at p<0.05. The study recommends that parastatal organizations' management should ensure that there is  proper contact preparation, each contract being managed by a competent contract management team, and there is enough budget allocation for every  project before it is started.
Effect of Audit Opinions and Entity's Characteristics on Audit Committees' Effectiveness in Government Entities in Tanzania
Authors: Mwombeki Frank Arbogast
Published: February 2023

This paper examines the influence of audit opinions and entity characteristics on audit committee effectiveness (ACE) in government entities. Using a  large sample of government entities in Tanzania as a reference, the paper adopted the resource dependency theory to explain the theme. Data were  collected from 230 government entities' financial statements and Controller and Auditor General (CAG) reports from 2014/15 to 2019/20. The ordinary  least square (OLS) technique was utilised to obtain regression results. The results show that disclaimer opinion negatively affects Audit Committee (AC)  effectiveness. Qualified Opinion and Adverse Opinion were found to be insignificant though they had a negative relationship the same as disclaimer  opinion. Specifically, unqualified opinion is a significant positive aspect related to AC effectiveness. Furthermore, entity structure, size, and location  significantly and positively influenced AC effectiveness. On the other hand, firm age had statistically insignificant effect. The study findings imply that an  entity should have experienced/competent audit committee members in accountancy. Also, the audit committee must be well-composed and have  sufficient resources to obtain a clean report. Therefore, the paper recommends inviting the national audit office to every audit committee meeting. The  board and management should emphasise on the budget for the training AC members. Further, the President's Office - TAMISEMI and the ministry  responsible for finance should insist on the establishment and activeness of AC in all government entities in Tanzania. As per the author's knowledge, this  paper adds new empirical knowledge by utilising CAG reports to link the effectiveness of AC with audit opinions and entity characteristics in  Tanzania.
The Mediation Effect of Business Environment on How Firm Characteristics Relate to Environmental Disclosure in Tanzania's Extractive Industry
Authors: Ponsian Ntui , Chalu Henry , Mzenzi Siasa
Published: February 2023

This study determines the function of the business environment as a mediating factor on how firm characteristics relate to the environmental disclosure  in the Tanzanian extractive industry through legitimacy and stakeholder theories lens. The analysis makes use of panel data from the 2018 Tanzania  Extractive Industry Transparency Initiative (TEITI) report covering the years 2004 to 2018, following the adoption of an environmental management Act  and its implementing laws in Tanzania. To extract data from yearly reports, the manifest content analysis was employed. The results show that the  relationship between corporate profitability, size, and environmental disclosure is mediated by pressure of stakeholders. Furthermore, the findings imply  that the relationship between size of firm and environmental disclosure is mediated by visibility by the media. However, the legal need does not operate  as a buffer between any firm characteristic and environmental disclosure, indicating that laws, regulations, and rules are not the only drivers of  environmental disclosure. For the first time, the study introduces, quantifies, and examines the business environment as the only justification for  environmental disclosure. The study combines legitimacy and stakeholder theories, treating businesses as entities with internal decision-making  processes that are also influenced by pressure from the outside world. The study also suggests that enhancing environmental disclosure and business  participation may not be possible with just rules or legislation. The study demonstrates that stakeholder theory works more effectively in situations when  powerful stakeholders put significant pressure on businesses to disclose environmental information. In terms of society, the study would promote  social involvement in ensuring that businesses disclose and protect the environment so that people can live in safety.
Challenges Facing Learners’ Acquisition of Employability Competencies under Competency-Based Education and Training Approach in Vocational Education and Training Centres in Tanzania
Authors: Mgaya Shukurani
Published: February 2023

The purpose of this article is to investigate the causes of inadequate employability competencies among vocational education and training (VET)  graduates using a competency-based education and training (CBET) approach. The article identifies respondents' perspectives on the challenges of  acquiring employability competencies during the civil artisans' training and learning process in VETIs under CBET and explores opinions for overcoming  those challenges. Data were gathered from 126 respondents through semi-structured interviews with trainers and employers, an open-ended  questionnaire for learners, and employee-focused group discussions. A qualitative exploratory approach research design was used. Thematic analysis  was used to analyse documents and interview transcripts. The findings revealed that the acquisition of employability competencies is hampered by  learner characteristics, insufficient training and learning resources, shortage of trainers, English language problems, training methods, and negative  perception of parents and learners on VET programmes, all of which were identified in the conceptual framework and mentioned by all categories of  respondents. It is likely that the challenges discovered were not novel, with the exception of a lack of internet and a scarcity of clean water and food,  which were context-specific issues. As a result, the study recommends that government and VET stakeholders should ensure the availability of learning  resources to enhance effective training and learning at VET. More serious English language instruction should begin in primary school, according to the  government and VET stakeholders. VET trainers should improve field supervision exercises and expose trainees to the working environment where  employability competencies can be imparted more easily than through classroom training alone. Trainers should also participate in workshops and  industrial visits to gain skills and knowledge about labour market needs. This will improve trainers' and trainees' understanding of labour-market  requirements.
Quality Assessment of Borehole Water in-Terms of Selected Physicochemical Parameters in Maiduguri Urban Areas, Borno State, Nigeria
Authors: Musa A. , Mala B. M. , Bukar L. K. , Wakil N. A.
Published: February 2023

In Nigeria, over 120 million peoples use boreholes as their main source of drinking water and in-view of the increasing volume of solid waste materials in Maiduguri, it has become exigencies to evaluate the quality of borehole waters in the city. The objective of this paper is therefore to evaluate some physicochemical characteristic of borehole water samples in Maiduguri urban areas Borno State, Nigeria using standard methods. Result obtained revealed that the pH of all the water samples was within the range of 6.5 to 8.5 as recommended limit by World Health Organization (WHO). Except for the pH of borehole water at Bulumkutu ward which is acidic (6.2). The pHs of all the water from the three wards were alkaline. The total dissolved solid and the electrical conductivity of water samples from the three wards fall within the limit of WHO, except water samples from Ngarannam (1100 mg/l) and (2220 uS/cm). The concentration of major ions (Na, Mg and K) fall far below the WHO recommended limit and thus the water can said to be excellent in terms of these elements. Except for Cl ion (262 mg/g) at borehole water in Gwange ward fall above the permissible limit by WHO. The study recommends performing regular testing of different water sources within the study area to ensure that commensurate attention given is maintaining a healthy population.
Sini San inhibits breast cancer cell migration and angiogenesis via the HIF 1 /VEGF pathway
Authors: Zhang Tingting , Lu Chen , Lv Mingming , Du Shengwang , Wu Xinjun , Wang Changqin
Published: February 2023

Purpose: To investigate the effects of Sini San (SNS) on breast cancer (BC), and the mechanism of action.Methods: MDA-MB-231 and SK-BR-3 cells were used as breast cancer cell models. Cell viability, migration, and invasion were determined by CCK-8, Transwell and wound healing assays, respectively. SNS mechanism of action and its anti-cancer effect were investigated by network pharmacological analysis, and further verified by Immunoblot.Results: Sini San inhibited the proliferation of the breast cancer (BC) cells., and also suppressed the migration as well as the invasion of BC cells, and also restrained the angiogenesis of BC cells. In performing the network pharmacological analysis of Sini Powder in the treatment of BC, 337 drugdisease targets were obtained. PPI network was established through String, and GO and KEGG enrichment analysis was performed on the target sites. KEGG analysis showed that genes were enriched in HIF-1 and VEGF pathways.Conclusion: Sini San suppressed cell migration as well as angiogenesis via the HIF-1 /VEGF pathway
Anti cancer molecular mechanism of Actinidia chinensis Planch in gastric cancer based on network pharmacology and molecular docking
Authors: Chen Yuye , Zhu Xiaoyong , Su Xiyang
Published: February 2023

Purpose: To determine the anti-tumor effects of Actinidia chinensis Planch (ACP) root extract as well as its mechanism of action against gastric cancer (GC) using network pharmacology.Methods: The bioactive compounds and targets of ACP, as well as GC-related genes were identified from a series of public databases. Functional enrichment analysis was conducted to find relevant biological processes and pathways. The survival analysis was conducted using GEPIA tool. Autodock was used to carry out molecular docking between the ingredients and their targets.Results: A total of 20 bioactive compounds with 209 corresponding targets were identified for ACP, and a total of 871 GC-related genes were obtained. Forty-nine (49) targets of ACP were identified as candidate genes for the prevention of GC, and the PPI network with 584 interactions among these genes was constructed. The data demonstrated that the candidate targets were involved in multiple biological processes such as oxidative stress response, apoptosis, and proliferation. Moreover, these candidate targets were significantly associated with cancer-related pathways and signal transduction pathways. The compound-target-pathway network containing 16 bioactive compounds, 49 targets and 10 pathways was constructed and visualized, and the top 3 targets with a higher degree value were AKT1, MYC, and JUN, respectively. Survival analysis revealed significant associations between GC prognosis and several targets (PREP, PTGS1, AR, and PTGS2). Molecular docking further revealed good binding affinities between bioactive compounds and the prognosis-related targets, indicating the potential roles of these ingredient-target interactions in GC protection.Conclusion: Taken together, this study has provided novel clues for the determination of the antigastric cancer mechanism of ACP.
Efficacy of cisplatin and fluorouracil chemotherapy plus Jianpi Yiqi formula in the treatment of advanced gastric cancer
Authors: Qiao Xiting , Li Na
Published: February 2023

Purpose: To investigate the efficacy of cisplatin and fluorouracil chemotherapy in combination with the Jianpi Yiqi formula in the treatment of advanced gastric cancer.Methods: A total of 64 patients with advanced gastric cancer admitted and treated at Xianyang Central Hospital from April 2019 to October 2021 were recruited and assigned equally to chemotherapy group and combination group according to the time of admission. Chemotherapy group received cisplatin and fluorouracil, while the combination group received the Jianpi Yiqi formula based on the treatment given to the chemotherapy group. Some clinical indices were evaluated in the patients.Results: Intervention in the combination group was associated with a higher total effectiveness when compared with chemotherapy group (p < 0.05). Cisplatin and fluorouracil plus Jianpi Yiqi formula resulted in significantly higher European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30-item (EORTC QLQ-C30) score than cisplatin with fluorouracil (p < 0.05). Furthermore, cisplatin and fluorouracil plus Jianpi Yiqi formula led to considerably higher Karnofsky Performance Scale (KPS) scores versus cisplatin with fluorouracil (p < 0.05).Conclusion: In the treatment of advanced gastric cancer, cisplatin-fluorouracil chemotherapy in conjunction with the Jianpi Yiqi formula produces remarkable efficacy. This strategy increases lesion dissolution rates, improves the quality of life and behavioral status of patients, and reduces adverse reactions, resulting in prolonged patients' progression survival (PFS) and overall survival (OS) levels.
Perfluorocarbon restrains inflammation and cell apoptosis in rats with lung ischemia reperfusion injury via down regulation of TLR4/NF κB signaling pathway
Authors: Liu Li , Gou Dan , Song Yanyan , Li Mingliang , Gu Jiwei , Zhang Yujing , Qu Chengliang , Wang Yun
Published: February 2023

Purpose: To exaluate the effect of perfluorocarbon on lung ischemia-reperfusion injury in rats, and to unravel the potential underlying mechanism.Methods: A total of 36 Sprague-Dawley (SD) rats were randomly assigned to sham group, model group, and perfluorocarbon group (12 rats per group). The levels of inflammatory factors (TNF-α and IL1β) were determined using enzyme-linked immunosorbent assay (ELISA). Cell apoptosis was evaluated by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) assay, while Western blotting was conducted to determine the protein expressions of TLR4 and NF-κB.Results: The levels of inflammatory factors in the model and perfluorocarbon groups were significantly higher than those in operation group (p < 0.05), while their levels in perfluorocarbon group were significantly lower than in model group (p < 0.05). The mRNA expression levels of TNF-α and IL-1β in lung tissues rose significantly in both model and perfluorocarbon groups when compared with those in sham group (p < 0.05), but declined significantly in the perfluorocarbon group in comparison with those in model group (p < 0.05). Furthermore, the perfluorocarbon group exhibited a significantly lower cell apoptosis than model group (p < 0.05). The relative protein expression levels of TLR4 and NF-κBdeclined significantly in perfluorocarbon group than in model group.Conclusions: Perfluorocarbon down-regulates the TLR4/NF-κB signaling pathway, and inhibits inflammation an
EU Recovery Plans, Inclusive Knowledge Economy and Overcoming Regional Disparities
Authors: Nahtigal Matjaz
Published: February 2023

The EU has adopted the Recovery and Resilience Facility (RRF) as the key instrument help to ensure that the EU, its member states, regions and local communities emerge stronger and more resilient from the pandemic crisis. Its main goal is to achieve climate neutrality by 2050, and it sets Europe on a path of digital transition, creating jobs and spurring growth in the process. The EU recovery plans should be seen as an opportunity not merely to address the post-pandemic health, social, economic and financial crisis – further exacerbated by the ongoing war in Ukraine – but primarily to develop a more inclusive and innovative institutional framework for European economies with more resilient local communities, small and medium sized firms, and high-quality public services across the EU. New forms of participation, more policy space, tools and instruments to support local and regional development strategies are necessary to establish an overall environment more hospitable to sustainable and inclusive development. Diversity of European local communities and European regions at different levels of development require tailored-made approach to realize their development potential. Institutional innovations, such as the regional public venture funds, may be the key to overcome regional disparities and build regional knowledge economies. The positive experience with the recovery, sustainable transition and inclusive knowledge economy across the European Union may serve as an important experience and encouragement to many other parts of the world, coping with the post-pandemic recovery, implementation of the Sustainable Development Goals and inclusive development.
Increasing Equitable Access to Care: Implementation of Universal Palliative Care Screening in the Intensive Care Unit
Authors:   , Weaver Sarah
Published: February 2023

Practice Problem: At a small community hospital in Virginia, there is an absence of standardized screening processes for identifying intensive care unit (ICU) patients with unmet palliative care needs, contributing to delayed and unequitable access to palliative care consultations. PICOT: The PICOT question that guided this project was “In adult ICU patients, how does implementing a palliative care screening tool upon ICU admission, as compared to standard ICU admission protocol, affect palliative care consultations within an 8-week time frame?" Evidence: This project was guided by consensus reports from the World Health Organization and the Centers to Advance Palliative Care, systematic reviews, and retrospective cohort studies evaluating the use of palliative care screening tools in the acute care setting. Intervention: In a 6-bed ICU, a validated palliative care screening tool was implemented over an 8-week period to screen all ICU patients within 24 hours of admission. Pre and post-implementation data were collected from the electronic medical record to analyze the number of ICU patients screened, patients with positive screenings, and palliative care consultations placed. Outcome: Overall screening compliance was 71 percent for all ICU patients, with 66 percent screened within 24 hours of admission. Although there was not a significant increase in palliative care consultations, the time from ICU admission to consultation decreased by 2.88 days and the ICU mortality rate for patients with consultations decreased by 83 percent. Conclusion: The palliative care screening tool did not generate more palliative care consultations; however, this tool facilitated identification and consultation for patients earlier in the ICU stay. More work is needed to overcome barriers to consultation and expand access to palliative care services throughout all inpatient units.
CADERNOS DE LANZAROTE: O DIÁRIO COMO “ESPELHO DE CONFIANÇA”
Authors: Brito da Silva Marcelo , Carvalho Pereira Vinícius
Published: February 2023

O artigo analisa um dos usos que José Saramago fez dos Cadernos de Lanzarote, a saber, o diário como forma de comprazimento próprio ou, conforme expresso no prefácio à obra, um “espelho de confiança”, bem como excertos que registram o modo como o escritor reagiu a acusações de uma escrita narcisista. São  acionados autores que refletiram sobre a escrita diarística de modo geral, como Lejeune (2014), Didier (1991), Rocha (1977) e Gusdorf (1991) e, pelo lado da crítica saramaguiana, contribuições de Seixo (1987), Baptista (1997), Reis (1996), Mathias (1997) e Altemberg (2002). Nossa análiseindica que os diários de Saramago revelam um homem que cultiva uma autoestima sã diante de seus sucessos, temperada por uma retórica damodéstia.
AS MEMÓRIAS DE PLÍNIO MARCOS:
Authors: Faulhaber Gabriel Moreira , Caruso Luigi
Published: February 2023

O objetivo deste trabalho é analisar o empreendimento memorialístico do dramaturgo brasileiro Plínio Marcos. Pretendemos abordar Figurinha difícil: pornografando e subvertendo (1996), seu livro de memórias, privilegiando seu aspecto político. Apresentamos as ideias do teórico francês Jean-Louis Jeannelle para apontarmos a especificidade e o funcionamento das memórias perante outras práticas da escrita íntima. Procuramos salientar o modo como a  escrita do autor movimenta, celebra e afirma uma singular política de vida exaltando os afetos que o atravessam e a coletividade a que pertence. Para isso, trazemos para discussão teóricos e críticos como Philippe Lejeune, Gilles Deleuze e Suely Rolnik.
Manichaeism and Buddhism in Contact: The Significance of the Uyghur History and Its Literary Tradition
Authors: Kasai Yukiyo
Published: February 2023

The exchanges between Manichaeism and Buddhism are one of the most-discussed topics in the religious study of Central Asia. Old Uyghur materials are often used in these discussions because the Uyghurs experienced the religious shift from Manichaeism to Buddhism. The sources attest that Manichaean and Buddhist communities co-existed under Uyghur rule, although the period of co-existence was limited. Thus, the texts produced in that period could show traces of exchange between these two religious communities. Previous studies, however, concentrate on the religious exchanges and do not consider the Uyghurs’ literary tradition, their historical background, and the language development in Old Uyghur. This paper re-examines the materials cited in previous studies, reconsiders exchanges between the two religious communities under Uyghur rule, and addresses the results of this survey.
Shahrbānū's Recompense: Muslim and Non-Muslim Antagonists and the Hero-Imam in Rabīʿ’s Alī nāma
Authors: Warner George
Published: February 2023

This article explores the central antagonisms at work within the Alī nāma of Rabīʿ, a fifth/eleventh-century Persian epic by a Twelver Shīʿī poet narrating the deeds of ʿAlī b. Abī Ṭālib, in particular the battles of the Camel and of Ṣiffīn. It gives an analysis of this poem within its twin contexts of Shīʿī imamology and Persian poetry, illustrating how these fields are variously drawn upon, combined and challenged in the poem’s unique narrative of the imam, and arguing that Rabīʿ cultivates his oft-cited opposition between Arabo-Islamic truth-telling and Iranian/Zoroastrian deception as a means of navigating intra-Muslim sectarian dynamics. The article argues against reductionist views of the poem, demonstrating the hybrid nuance of its engagement with Sunnīs, Shīʿīs and the pre-Islamic past, as well as providing an overview of this under-studied work of literature.
СЕМАНТИЧНИ РАЗШИРЕНИЯ НА ГЛАГОЛИТЕ ЗА ВЪЗПРИЯТИЕ В АНГЛИЙСКИ И БЪЛГАРСКИ ЕЗИК ОТ КОГНИТИВНА ГЛЕДНА ТОЧКА
Authors:   Konstantin Preslavsky University of Shumen, Анева Цветалина
Published: February 2023

The study discusses the different extensions in the semantic field of visual, auditory, tactile, gustatory and olfactory perception verbs in English and Bulgarian within the framework of Cognitive Linguistics. The analysis outlines 41 patterns and a wide range of lexical meanings, realized within a given patternwith emphasis on how contextual meanings appear. The research aims to present a new approach to analyzing lexical items, by paying special attention to verbs denoting passive perception in particular.
РАЗКАЗИТЕ НА ЕЛИН ПЕЛИН В НЕМСКОЕЗИЧНОТО СПИСАНИЕ „DER BULGARIENWART“ В КОНТЕКСТА НА СЪБИТИЯТА В МЕЖДУВОЕННА БЪЛГАРИЯ
Authors:   Konstantin Preslavsky University of Shumen, Обретенова-Велинов Илияна
Published: February 2023

The third decade of the 20th century are considered in history as the time of preparation for the Second World War. Certainly propaganda is the way to reach the masses and the printed media was usually the tool to promote ideas to as many people as possible. In the periodical Der Bulgarienwart along with the publicistic texts there are many literary ones to find as well. The following article presents seven short stories by Elin Pelin, translated into German and published in the journal. By means of discourse analysis a first attempt is made to establish an interdisciplinary connection between the thematic scope of the short stories, the main translator Stefan Yovev‘ s views and the nationalsocialist propaganda ideas during the period.
Construções hostis: o direito da população em situação de rua à cidade
Authors: Goll Juan Carlo
Published: February 2023

Este trabalho apresenta a conceituação jurídica de “população em situação de rua” e o motivo da necessidade de delimitação desse objeto jurídico para a criação de políticas públicas, a fim de direcionar o Estado na criação de medidas para alterar a realidade social. Ademais, explica-se o que é a técnica de arquitetura hostil e que o intuito de sua utilização é afugentar a população de rua dos grandes centros urbanos com o objetivo de valorizar os imóveis em seu entorno. Por conseguinte, constatou-se que o Estado é cooptado para realizar políticas que beneficiam os setores econômicos mais poderosos e que o Projeto de Lei n° 488 de 2021 tem o objetivo de possibilitar o direito à cidade para toda a sociedade, em especial a população em situação de rua. Ainda, verificou-se que há a possibilidade de se utilizar as técnicas de construção hostil por meio de um exemplo. Por fim, concluiu-se que a lei foi necessária para garantir o referido direito, uma vez que ao se utilizar as técnicas hostis para afastar as pessoas em situação de rua, tolhe-se o direito de todos, bem como se constatou que alguns setores econômicos são os mais interessados, já que se beneficiam disso. A metodologia utilizada para a confecção desta pesquisa foi a indutiva e dedutiva, utilizando-se pesquisa bibliográfica (doutrina, artigos científicos, leis em lato sensu e notícias jornalísticas).
A Sociological Inquiry on Training and Treatment of the Wellbeing of Female Inmates in Correctional Facilities in Ogun and Lagos States, Nigeria
Authors: Olawunmi A. T , Folorunsho M Ogunmefun , Adesuwa L Aiwuyuse
Published: February 2023

All over the world, the UNODC policy of 2011 agitates for needs to train, treat and promote the wellbeing of female inmates so as to reduce and control rate of recidivism in the country. Women are considered as care givers whose duty includes socialisation; domestication and procreation of offspring for societal continuity. In Nigeria, once women are convicted or apprehended by law, they faces lot of challenges ranging from stigmatization, poor health treatment, isolation, psychological trauma, unequal treatment among others Relevance publications to include local and international journals, magazines, newspaper, textbooks and articles were reviewed and double deviance feminist theory was adopted for justification of the inquiry. A mixed method was adopted with cross sectional survey method. Total population for the study in the three selected correctional facilities in Lagos and Ogun states was estimated to 348 inmates but 250 was found useful for the quantitative analysis while 15 female inmates were selected for the qualitative analysis. The result indicated that there are many factors that increase female involvement in criminal acts ranging from greed, poverty, unemployment. The second result shows that the treatment available for female inmates has insignificant negative effect on their wellbeing while the last indicated that training have significant relationship with female wellbeing in the facilities. The government, non-governmental organisation and the philanthropists should collective support the promotion of the wellbeing of female inmates and adequate cares and supervision should be ensure through the use of CCTV cameras in the facilities