bluuebunny/crossref_metadata_2025 huggingface dataset:
Orbital Infiltration in a Patient with Waldenström Macroglobulinemia: Need for Multidisciplinary Approach and Comparison with the Literature
Authors: Paggi Riccardo , Mariotti Francesca , Mencarini Jessica , Bresci Silvia , Capolmi Irene , Bartalesi Filippo , Borchi Beatrice , Nassi Luca , Vannucchi Alessandro Maria , Bartoloni Alessandro
Published: April 2023

The use of specific inhibitory drugs of intracellular signaling pathways (such as Bruton-Kinase inhibitors) for the treatment of Waldenström's macroglobulinemia (WM) is a recognized risk factor for Aspergillus spp. infections. The overlapping clinical manifestations of the two diseases may require the involvement of different medical specialties.
IMMUNE THROMBOCYTOPENIA ONSET AND RELAPSE DURING THE COVID19 PANDEMIC. A MONOCENTER STUDY.
Authors: Auteri Giuseppe , Paglia Simona , Mazzoni Camilla , Biondo Mattia , Venturi Marta , Romagnoli Andre Davide , Bartoletti Daniela , Cavo Michele , Vianelli Nicola , Palandri Francesca
Published: April 2023

BACKGROUND AND OBJECTIVES

Several infections and vaccinations can provoke immune thrombocytopenia (ITP) onset or relapse. Information on ITP epidemiology and management during the Covid19 pandemic is scarce.

In a large monocenter ITP cohort, we assessed incidence of and risk factors for: 1) ITP onset/relapse after Covid19 vaccination/ infection; 2) Covid19 infection.

METHODS

Information on date/type of anti-Covid19 vaccine, platelet count before and within 30 days from vaccine and date/grade of Covid19, was collected via phone call or during hematological visits.

ITP relapse was defined as a drop in PLT count within 30 days from vaccination, compared to PLT count before vaccination that required a rescue therapy OR a dose increase of an ongoing therapy OR a PLT count <30 x109/L with ≥20% decrease from baseline.

RESULTS

Between February 2020 and January 2022, 60 new ITP diagnosis were observed (30% related to Covid19 infection or vaccination). Younger and older age were associated to higher probability of ITP related to Covid19 infection (p=0.02) and vaccination (p=0.04), respectively. Compared to Covid19-unrelated ITP, Infection- and vaccine-related ITP had lower response rates (p=0.03) and required more prolonged therapy (p=0.04), respectively.

Among the 382 patients with known ITP at pandemic start, 18.1% relapsed; relapse was attributed to Covid19 infection/vaccine in 52.2% of the cases. The risk of relapse was higher in patients with active disease (p<0.001) and previous vaccine-related relapse (p=0.006).

Overall, 18.3% of ITP patients acquired Covid19 (severe in 9.9%); risk was higher in unvaccinated patients (p<0.001).

CONCLUSIONS

All ITP patients should receive ≥1 vaccine dose and laboratory follow-up after vaccination, with case-by-case evaluation of completion of vaccine program if vaccine-related ITP onset/relapse, and with tempestive initiation of antiviral therapy in unvaccinated patients.
GENETIC PREDISPOSITION TO HEMATOLOGIC MALIGNANCIES IN CHILDHOOD AND ADOLESCENCE
Authors: Fabozzi Francesco , Mastronuzzi Angela
Published: April 2023

Advances in molecular biology and genetic testing have greatly improved our understanding of the genetic basis of hematologic malignancies and have enabled the identification of new cancer predisposition syndromes. The recognition of a germline mutation in a patient affected by a hematologic malignancy allows for a tailored treatment approach in order to minimize toxicities, and informs the donor selection for hematopoietic stem cell transplantation as well as the comorbidities evaluation and surveillance strategies.

This review provides an overview of germline mutations that predispose to hematologic malignancies, focusing on those most common during childhood and adolescence, based on the new International Consensus Classification of Myeloid and Lymphoid Neoplasms.
EVOLVING ROLE OF HAEMATOLOGY NURSING PRACTICE: A CROSS-SECTIONAL SURVEY
Authors: Liptrott Sarah , NíChonghaile Mairéad , O'Connell Liz , Aerts Erik
Published: April 2023

Background and Objectives: The scope of haematology nursing practice is dynamic and must respond to advances in treatment, patients’ needs and service requirements. Little is known however, about different roles of haematology nurses across the European setting. The purpose of this study was to identify professional practices of haematology nurses.

Method: A cross sectional online survey design was used to investigate practice elements undertaken by haematology nurses. Frequencies and descriptive statistics were calculated for demographic variables and chi-square tests to examine relationships between practice elements, nursing role and country.

Results: Data is reported from 233 nurses across 19 countries, working as Staff Nurses (52.4%), senior nurses (12.9%) and Advanced Practice Nurses (APNs) (34.8%). Most frequently reported activities included medication administration - oral/ intravenous (90.0%), monoclonal antibodies (83.8%), chemotherapy (80.6%), and blood components (81.4%). APNs were more commonly involved in nurse-led clinics and prescribing activities (p < .001, p = .001, respectively), however other nursing groups also reported performing extended practice activities. Patient and carer education was a significant part of all nurses roles, however senior nurses and APNs were more often involved with the multidisciplinary team (p < .001) and managerial responsibilities (p < .001). Nurses involvement in research was limited (36.3%), frequently reported as an out of work hours activity.

Conclusions: This study describes haematology nursing care activities being performed in a range of contexts and within different nursing roles. It provides further evidence of nursing activity and may contribute to a core skills framework for haematology nurses.
Endobronchial Leiomyoma
Authors: Rajeev Vyshnavi , Sundararajan L. , Jacob Sheba , Santhosham Rajiv
Published: April 2023

Leiomyomas are rare benign tumors of the lung. They arise from the smooth muscle cells of the bronchial wall and the interstitium or from the smooth muscles of the arterioles. Symptoms are chiefly based on the degree to which bronchial obstruction occurs. Bronchoscopic intervention or lung sparing surgical resection are the treatments of choice. In leiomyomas that are accessible by bronchoscopy and confined to airway, bronchoscopic resection appears to be safe and effective. This case is being reported because of the rarity of this condition and the need to recognise the role for endobronchial intervention, thereby, avoiding major surgical procedures with the attendant risk of morbidity due to surgery.
The Role of Computed Tomography Chest in Correlating with the Severity and Outcome of COVID-19 Patients Admitted in a Tertiary Care Hospital in South India
Authors: Kirubanandam A. , Ramakrishnan Gayathri Anur , Kapali Sunder
Published: April 2023

Aim:

To assess the role of computed tomography (CT) chest in correlating with the severity and outcome of COVID-19 Patients.

Background and Materials and Methods:

A prospective study was done on 160 hospitalized patients who were COVID-19 positive by reverse transcription-polymerase chain reaction in Apollo Hospital, Greams Road, Chennai, India. We collected epidemiological data, comorbidities, clinical manifestations, oxygen requirement, and CT chest details of all patients. All images were reviewed by a single consultant radiologist and CT chest severity scoring was done as per the guidelines published in the American Journal of Radiology. CT chest severity score (CTSS) was then compared with clinical severity and various parameters.

Results:

This study included 160 hospitalized COVID-19 patients with a mean age of 61 ± 13.97 years. Male (74.4%) patients were more when compared to female patients (25.6%). Majority of the patients were belong to mild category (44.38%), followed by severe (28.7%) and moderate (26.8%) categories. Fever (73.8%) was the most common symptom. Diabetes mellitus (57.5%) was the most common comorbidity of COVID-19 patients in our study, followed by hypertension (55%). The average CTSS of mild category was 7.4 ± 4.7; for moderate category, the mean CTSS was 14.6 ± 5.78; and for severe category, it was 18.3 ± 5.28. There was increasing trend of severity score, as clinical severity increases which was statistically significant (P = 0.0001). The mean CTSS of patients who required no oxygen, low flow oxygen, high flow oxygen, noninvasive ventilation, and intubated patients was 8.3 ± 5.71, 14.84 ± 5.39, 18.17 ± 5.7, 18.17 ± 6.04, and 22.18 ± 4.07, respectively, which was statistically significant (P = 0.0001). The mean CTSS of patients discharged without oxygen requirement was 11.09 ± 6.48 and patients discharged with oxygen requirement was 18.09 ± 6.12 (P = 0.001). The mean CTSS of patients who died was 20.27 ± 4.62.

Conclusion:

There was a significant correlation between CT chest severity score and clinical severity and oxygen requirement. CT chest is one of the best screening tools for rapid identification as well as to predict the clinical severity; thereby, it helps the clinician in managing the COVID-19 patients at crucial points during the progression of disease.
A-Survey: Identification and Classification of Fingerprints via the Extreme Learning Machine Algorithm
Authors: Zabala-Blanco David , Martinez-Pereira Diego , Flores-Calero Marco , Datta Jayanta , Dehghan Firoozabadi Ali
Published: April 2023

The fingerprint comes to be the most popular and utilized biometric for identifying persons owing to its bio-invariant characteristic, precision, as well as easy acquisition. A sub-system of an identification system is the classification stage in order to diminish the penetration rate and computational complexity. Actually, there are many formal investigations regarding techniques by exploiting convolutional neural networks  (CNN)  together with fingerprint images, which have superior performance metrics at the cost of large training times even employing high-performance computing, which is not feasible in the standard world. In our manuscript,  researches about identifying and classifying fingerprint databases by recurring to extreme learning machines (ELM) will be extensively reported and discussed for the first time. The diverse methodologies (ELM plus feature extractors) given by the authors will be studied and contrasted considering performance analysis.  Consequently,  academic papers with diverse versions of ELMs are developed to observe the pros and cons that they exhibit with each other and to probe how they may help for minimizing the penetration rate of fingerprint databases.  In fact,  this issue is very relevant because enhancing the penetration rate means shorting search times and computational complexity in fingerprints.
Quality of Life
Authors: Nakova Albena
Published: April 2023

The thematic focus of this issue of Postmodernism Problems is the dynamics and transformations in the quality of life of social communities in Bulgaria and Romania. The publications in it are the result of the implementation of a joint research project under the inter-academic cooperation between the Bulgarian and Romanian Academies, and more specifically between the Institute of Philosophy and Sociology at the Bulgarian Academy of Sciences and the Research Institute for Quality of Life at the Romanian Academy on the topic: “Transformations in the quality of life of social communities in the conditions of globalization: challenges and perspectives (2022 – 2023)”. The concept of quality of life has a very high heuristic potential as it affects a wide range of contexts, including social development, politics, employment, and international relations. In this issue of Postmodernism Problems, we tried to present some specificities of Bulgaria and Romania in terms of the state, dynamics, and perspectives of the quality of life in both countries in the aspect of its various objective and subjective indicators. The results show that there are many similarities between the two countries, both historically and culturally, and in the most recent developments of Bulgaria and Romania after 2007 in relation to EU membership. This familiar context has repercussions on social processes related to changes in the quality of life of local communities. The study of transformations in the quality of life of different social communities in the two neighboring countries enriches the research field on the topic and allows for an analysis of what is happening in two related national contexts in the conditions of globalization.
Disasters – Sociocultural Effects on the Quality of Life of Local Communities
Authors: Nakova Albena , Milenkova Valentina
Published: April 2023

This article presents an analysis of the impact of disasters on the quality of life of local communities. Its empirical basis is collected field material within the framework of a study conducted by the Institute for Еthnology and Folklore Studies with the Ethnographic Museum at the Bulgarian Academy of Sciences as part of the project "Local Disasters and Quality of Life: Cultural Strategies in Overcoming Natural, Technological and Biological Catastrophes", funded from National Science Fund of the Ministry of Education and Science. The empirical data, on the basis of which the theoretical analysis is carried out, concern two natural disasters that occurred in Bulgaria - the earthquake in Pernik in 2012 and the flood in the Asparuhovo district in 2014. Research results show that the disaster affects, albeit to different degrees and in different ways, all components of the "quality of life" category, changing them at the moment or creating conditions for their later change. It has a powerful impact on the material and economic side of people's lives as the basis of their social well-being, which is entirely in a negative direction. Also negative is the impact of the disaster event on the affected person's physical and mental health, sense of security, tranquility, and mental balance. Unexpectedly, it turns out that disaster can also positively impact people's quality of life. This is most often in terms of their social connectedness and cohesion when the disaster event catalyzes social connections and support. Striving to restore the pre-disaster quality of life leads to social change that reflects the experience of survival through changes in local traditions and everyday life and the creation of new cultural memory and places of memory, thus building a new post-disaster model of social relations, accumulating gained experience and refracting it through the unique situation.
A Critical Reflection on the "Deficits to be Overcome" in Urban Agriculture in Bulgaria
Authors: Hristova-Vladi Svetlana
Published: April 2023

What are the real vs. the potential effects of urban agriculture (UA) on the welfare of communities living in the city and the close-by areas – this is amongst the main queries posited by the book "Urban Agriculture for Improving the Quality of Life. Examples from Bulgaria", edited by Donna Pickard. A multidisciplinary study that leans on scientific data and unravels the interplay between the impact of UA practices and the quality of life. Content-wise, this research involves multi-layered analyses on the subject – UA has been viewed through social, educational, economic, spatial, and ecological aspects. At the beginning of the book, there is a text about the historical dimension of UA in Bulgaria, revealing curious information about what urban agriculture looked like in the 1930s in Sofia. An intriguing find, for instance, is that people working in the newly established National Assembly raised poultry in a parliamentary annex building during the first years of their service. The book has been awarded the scientific and applied achievement of the Institute of Philosophy and Sociology at the Bulgarian Academy of Sciences (IPhS-BAS) for 2022 after the General Assembly of Scientists vote in January 2023. The values of this scientific work are listed below.
Performance Study of Monocrystalline Type Solar Panels for Street Lighting in Sibolga Area
Authors: Eka Saputra Yuli Mafendro Dedet , Ramadhan Mochamamd Tendi Noer
Published: April 2023

In the Sibolga area, there is still a shortage of electricity supply, especially for street lighting, so accidents often occur, meanwhile there has a relatively large average solar radiation intensity is 4,784 Wh/m2/day so that potential for PLTS installation. This research aims to determine the performance of monocrystalline solar panels with the addition of a heatsink cooling fan in street lighting. The method used is an experimental. The test begins with the survey, potential calculation, design, testing, data collection and analysis. The solar panel used monocrystalline 10 WP with a heatsink cooling fan. The parameters are the panel temperature, voltage, and current from the solar panel. The results obtained are the temperature on the solar panel without heatsink cooling fan reaches 56.10°C with efficiency 11% and on the solar panel with heatsink cooling fan only gets 45.50°C with efficiency increases to 13%. This shows that the addition of a heatsink cooling fan has succeeded in cooling the temperature of the solar panels and increasing the efficiency level of solar panel performance for street lighting.
Penetration Impact of Distributed Generation of Wind Turbines on PLN’s Electric Distribution Network at Krueng Raya Aceh Besar
Authors: Putra Renno Kamal , Daud Muhammad , Setiawan Adi , Hasibuan Arnawan
Published: April 2023

Distribution of electricity that is too far away can cause the power flow that flows in the distribution channel to be significantly reduced. This also occurs in the PLN distribution line in Krueng Raya Aceh Besar, which is 95 km away, so that the voltage value is often below the standard value. This study analyzes the use of dispersed generators as an alternative solution to overcome this problem while increasing the efficiency of the electricity distribution system. However, the operation of distributed generators can have an impact on distortion harmonics in the voltage, current, and frequency of the power flow in the distribution network system. This study is focused on analyzing the penetration impact of dispersed wind energy generators on the distribution line by conducting simulations using ETAP. The results can increase the average value of the voltage profile by 0.077 kV or 0.39%, reduce power losses by 6.628 kW and THDv values ​​by 0.004% to 0.018% and THDi by 0 on all buses.

Penyaluran listrik yang terlalu jauh dapat menyebabkan aliran daya yang mengalir dalam saluran distribusi berkurang secara signifikan. Ini juga terjadi pada saluran distribusi PLN di Krueng Raya Aceh Besar yang jaraknya mencapai 95 km sehingga nilai tegangannya sering berada di bawah nilai standar. Penelitian ini menganalisis penggunaan pembangkit tersebar sebagai alternatif solusi untuk mengatasi masalah tersebut sekaligus meningkatkan efisiensi sistem distribusi listrik. Namun, pengoperasian pembangkit tersebar dapat menimbulkan distorsi harmonisa pada tegangan, arus, dan frekuensi pada aliran daya dalam sistem jaringan distribusi. Studi ini difokuskan pada analisis dampak penetrasi pembangkit tersebar energi angin pada saluran distribusi dengan melakukan simulasi menggunakan ETAP. Hasil penelitian dapat meningkatkan nilai rata-rata profil tegangan sebesar 0,077 kV atau 0,39%, mengurangi rugi-rugi daya sebesar 6,628 kW serta nilai THDv sebesar 0,004% sampai 0,018%  dan THDi sebesar 0 pada seluruh bus.
Determination of the Shortest Route for Inorganic Waste Transportation Using the Clarke and Wright Saving Algorithm
Authors: Azzahra Vira Luthfiati , Fauzi Muchammad
Published: April 2023

Piles of inorganic waste in Margasari Village, Bandung City, were recorded at 5,556.5 kg/day on average Waste management at RW 01, 09, 11 and 14 has been carried out, but it is still not optimal because there is no garbage pickup route, this study purpose to produce an optimal route because it will have an impact on the distance traveled, completion time, transportation costs and exhaust emissions a vehicle. The method used is Clarke and Wright Saving. Transportation of inorganic waste is carried out once a week with the average volume of waste is 338 kg. Based on the results of the route research obtained, the route from Bank Sampah Bersinar→RW 11→RW 14→RW 09→RW 01→Bank Sampah Bersinar, the total distance is 24.6 km and the total completion time is 186.9 minutes. The route and distance show a total exhaust emission of CO 0,002792 ton/year; HC 0,000197 ton/year; NOx 0,000135 ton/year.. The transportation costs spend by the Bank Sampah Bersinar if one pick-up is 24.6 km away is IDR 984,000/year.

Tumpukan sampah anorganik di Kelurahan Margasari Kota Bandung tercatat rata-rata sebesar 5.556,5 kg/hari. Pengelolaan sampah pada RW 01, 09, 11, dan 14 telah dilakukan, tetapi masih belum optimal karena belum adanya rute penjemputan sampah, penelitian ini bertujuan untuk menghasilkan rute yang optimal karena akan berdampak pada jarak tempuh, waktu penyelesaian, biaya transportasi dan emisi gas buang sebuah kendaraan. Metode yang dipakai adalah Clarke and Wright Saving. Pengangkutan sampah anorganik dilakukan sebanyak satu kali dalam seminggu dengan rata-rata volume sampah adalah 338 kg. Berdasarkan hasil penelitian rute yang didapat yaitu Bank Sampah Bersinar→RW 11→RW 14→RW 09→RW 01→Bank Sampah Besinar, total jarak tempuh yaitu 24,6 km dan total waktu penyelesaian selama 186,9 menit. Pada rute dan jarak tersebut menunjukkan total emisi gas buang CO 0,002792 ton/tahun; HC 0,000197 ton/tahun; NOx 0,000135 ton/tahun.. Biaya transportasi yang dikeluarkan oleh Bank Sampah Bersinar jika sekali penjemputan sejauh 24,6 km sebesar Rp 984.000/tahun.
Site Selection for the Citronella Oil Distillation Unit at Rambatan Subdistrict Tanah Datar Regency
Authors: Adi Alexie Herryandie Bronto , Wirdianto Eri , Amadea Felia Devina , Jumeno Desto , Patrisina Reinny
Published: April 2023

The Sarasah Village Cooperative (KUD Sarasah) located in Nagari III Koto, Rambatan Subdistrict, Tanah Datar Regency plans to build a citronella oil distillation unit. The decision about the location where to build a factory is a strategic decision that needs to be considered carefully, because it involves a large amount of investment and has a long-term impact. This study aims to select the location of the construction of citronella oil distillery. The method used in this research is the Analytical Hierarchy Process. The conclusion that can be drawn regarding the most strategic location for the construction of a citronella oil production house is Aur Serumpun with a weight of 47.9% whereas the Long-Term aspect is the most influential criterion with a weight of 43.4%.

KUD Sarasah yang berlokasi di Nagari III Koto, Kecamatan Rambatan, Kabupaten Tanah Datar berencana membangun rumah produksi penyulingan minyak serai wangi. Keputusan tentang lokasi tempat pendirian pabrik merupakan keputusan strategis yang perlu dipertimbangkan secara cermat, karena menyangkut investasi dalam jumlah besar dan memiliki dampak jangka panjang. Penelitian ini bertujuan untuk memilih lokasi pembangunan rumah produksi minyak serai wangi. Metode yang digunakan di dalam penelitian ini adalah Analytical Hierarchy Process. Kesimpulan yang dapat diambil terkait lokasi yang paling strategis sebagai tempat pembangunan rumah produksi minyak serai wangi adalah di Aur Serumpun dengan bobot sebesar 47,9% dimana aspek Jangka Panjang adalah kriteria yang paling mempengaruhi keputusan penentuan lokasi dengan bobot 43,4%.
Computer Vision Implementation in Scratch Inspection and Color Detection on The Car Roof Surface
Authors: Candra Wahyu Adhie , Sunarya Adhitya Sumardi , Saraswati Wening Sukma
Published: April 2023

The automotive industry in Indonesia is one of the important pillars in the manufacturing sector. High speed productivity and high-level quality of their products are required for increasing the company value. The car roof inspection is still in low speed and inadequate quality control method for most of the car company’s manufacturing production line. This inspection process is highly dependent to human expertise and skill of the assembly operators.  This study purposes to increase the productivity in the inspection line by eliminate human error using computer vision. This research aims to find an automatic and accurate method for visual inspection of the color quality and scratch defect on car roof surfaces, using the data generated from the standardized database QR Code.  The proposed solution uses MobileNet-SSD method of computer vision in recognizing scratch defects, while color detection of the roof is attained through hue saturation method. The study employs data capture from a camera and compares the amount of object inspected in real time. The scratch inspection with 70 image samples and 4000 training steps results in a 3.33% error with color detection and inspection success rate of 80%.
Estudio bibliométrico en SCOPUS sobre el turismo de naturaleza en la gestión de destinos turísticos
Authors: Sánchez Calero Alianet De la Caridad , Varona Leyva Frank Luis , Avilas Hernández Jorge Raúl , Ochoa Ávila Migdelys Barbarita
Published: April 2023

En los últimos tiempos el cuidado del medioambiente se ha convertido en uno de los factores decisivos a la hora de escoger el destino por parte de los turistas, en este sentido adquiere gran importancia el turismo de naturaleza. Por la relevancia del tema en la actualidad, se ha realizado el presente artículo cuyo objetivo es desarrollar un estudio bibliométrico sobre el turismo de naturaleza y su perspectiva para los destinos. Para esto se utilizó la metodología propuesta por Diana Lorena Pineda Ospina la cual cuenta con tres pasos; así como la revisión documental de artículos publicados en la base de datos Scopus en el período 2001-2023. Para ello se emplearon herramientas como Endnote X7, Excel 2019, Biblioshiny y VOSviewer 1.6.16 para el procesamiento y visualización de los datos. Los resultados muestran que la producción científica sobre el tema es baja. Como parte de la revisión bibliográfica que complementa la presente investigación, se determinaron las principales brechas de investigación: el uso de técnicas y teorías para determinar y examinar el turismo de naturaleza, además de la necesidad del uso de métodos avanzados y enfoques integrados para evaluar las perspectivas del mismo.
Modelo de Gestión Financiera y toma de decisiones en las medianas empresas, análisis de estudios previos
Authors: Zumba Margarita , Jácome Julio , Bermúdez Cristhian
Published: April 2023

La finalidad de la gestión financiera es consolidarse como una herramienta para las empresas, de tal forma que le entregue información adecuada para la toma de decisiones, el presente informe contempla el desarrollo de los fundamentos teóricos, conceptuales y referenciales sobre la gestión financiera y su impacto en la toma de decisiones empresariales, por medio de una revisión de la literatura y análisis previos. Este primer proceso de revisión se ha elaborado con la intención de establecer un marco teórico sólido el cual permita definir a las variables analizadas, para luego desarrollar la recolección de los datos e información que permita el desarrollo de un análisis estadístico futuro. Durante este proceso de investigación se realizó un estudio sobre las principales características de la gestión financiera, medianas empresas y toma decisiones, la información recopilada permite seguir con el proceso investigativo, de esta manera se determinó que un modelo de gestión financiera es de vital importancia para la toma de decisiones.
Lupus eritematoso sistémico y síndrome antifosfolipídico secundario.
Authors: Lema Guaraca Christian Alexander , Lopez Lopez Luis Angel , Alvarez Vasquez Michelle Carolina , Chazi Inga Oswaldo Felipe , Heredia Sánchez Erik Antonio
Published: April 2023

Resumen
Introducción: El Síndrome Antifosfolipídico (SAF) es una enfermedad autoinmune caracterizada por la presencia de anticuerpos anticardiolipina (aCL), anti Beta 2 Glicoproteina (B2GP) o anti Coagulante Lúpico (AL) junto con la presencia de trombosis vascular o complicaciones durante el embarazo. El SAF puede ser de origen primario o secundario, siendo usualmente asociado con el Lupus Eritematoso sistémico (LES), enfermedad que compromete al tejido conjuntivo causando inflamación crónica y sintomatología que afecta a diferentes órganos; su incidencia puede ir desde tres hasta doscientos casos por cada cien mil habitantes (1).
Caso clínico: Se presenta el caso de una paciente femenina de cincuenta y cuatro años con antecedentes de insuficiencia venosa, hipertensión arterial, epilepsia idiopática de inicio tardío, insuficiencia renal crónica, demencia, anemia normocítica normocrómica, trombosis venosa profunda en miembros inferiores y abortos a repetición que acudió a consulta externa por presentar ulcera crónica en región del maléolo externo de miembro inferior derecho que no remite a pesar del tratamiento. Se ingresa a casa de salud para completar estudios de extensión encontrando ANAS, ENAS y VDRL positivo, hipocomplementemia, hiperprolactinemia, trombocitopenia y anemia hemolítica.
Evolución: El manejo de la paciente consistió en un tratamiento farmacológico, centrado en el uso de anticoagulantes e inmunosupresores; además de un tratamiento quirúrgico, pues se sometió a un procedimiento de injerto de piel, a la cual presentó rechazo. Actualmente, la paciente se encuentra en proceso activo de su patología manteniéndose con tratamiento a base de cloroquina y azatioprina.
Conclusión: Se debe considerar la existencia de enfermedades autoinmunes dentro de los diagnósticos diferenciales ante la aparición de un cuadro clínico caracterizado por pacientes de sexo femenino con abortos a repetición, alteraciones vasculares y hematológicas y presencia de anticuerpos positivos que afectan al tejido conjuntivo. El diagnóstico temprano de lupus eritematoso sistémico y síndrome antifosfolipídico contribuye a instaurar un oportuno tratamiento y a mejorar la calidad de vida de los pacientes al prevenir complicaciones discapacitantes
Condiloma acuminado vulvar gigante em paciente transplantada renal: relato de caso
Authors: De Oliveira e Silva Jaine , De Oliveira Lia Rakel Rocha
Published: April 2023

O condiloma acuminado gigante, variante rara do condiloma acuminado anogenital, apresenta crescimento rápido associado a estados de imunodeficiência. Objetivo: relatar o caso de um condiloma acuminado vulvar gigante, em uma paciente transplantada renal, demonstrando o tratamento instituído, bem como sua evolução . Relato de caso: Paciente feminino, 19 anos, encaminhada do ambulatório de ginecologia do Hospital Getúlio Vargas para tratamento cirúrgico de extensa lesão vulvar de aspecto condilomatoso, tipo couve-flor, desde a vulva até região perianal. Em virtude de insucesso terapêutico prévio com uso de aplicações de podofilina, assim como o tamanho da lesão vulvar, foi proposta a realização de vulvectomia simples. A paciente apresentou sinais de infecção da ferida operatória. Realizado antibioticoterapia, com bons resultados. Considerações finais: não há tratamento capaz de erradicar o HPV atualmente, nem ideal para todas as pacientes ou todos os condilomas. Dessa forma, o tratamento deve ser individualizado.
PENGARUH BIAYA OPERASIONAL TERHADAP LABA BERSIH PADA BANK SWASTA NASIONAL YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Ge’e Finsensia , Waruwu Krisrefistaria , Damanik Hormaingat , Sitompul Johari
Published: April 2023

Penelitian ini bertujuan untuk mengetahui apakah biaya operasional berpengaruh signifikan terhadap laba bersih pada Bank Swasta Nasional yang terdaftar di Bursa Efek Indonesia. Hipotesis yang diajukan adalah “Terdapat pengaruh biaya operasional terhadap laba bersih pada Bank Swasta Nasional yang terdaftar di Bursa Efek Indonesia”. Populasi dalam penelitian ini sebanyak 43 perusahaan, sedangkan sampel dalam penelitian ini sebanyak 27 perusahaan dengan data laporan keuangan tahun 2019-2021. Pengumpulan data dilakukan dengan penelitian kepustakaan dan penelitian lapangan. Untuk menguji hipotesis menggunakan data deskriptif dan analisis regresi linear sederhana, uji asumsi klasik, uji t, koefisien korelasi determinasi dengan bantuan software SPSS 2022 (Statistical Product and Service Solutions). adapun hasil penelitian yang telah dilakukan maka didapat beberapa kesimpulan sebagai berikut: biaya operasional berpengaruh secara signifikan terhadap laba bersih, Berdasarkan kesimpulan yang dikemukakan agar perusahaan meminimalkan biaya operasional yang nantinya berpengaruh terhadap laba perusahaan.
LITERATURE REVIEW: PERAN BRAND AMBASSADOR TERHADAP KEPUTUSAN PEMBELIAN MELALUI MINAT BELI
Authors: Putra Halim Dwi , Lubis Renny , Asir Muhammad , Muthalib Dzulfikri Azis , Anwar Muh. Abduh.
Published: April 2023

Media online pada saat ini tidak hanya berfungsi sebagai alat untuk mencari informasi, melainkan media online juga bisa digunakan sebagai media untuk memfasilitasi bisnis atau biasa disebut dengan bisnis online. Tujuan penelitian ini untuk melihat peran Brand Ambassador Terhadap Keputusan Pembelian Melalui Minat Beli. Artikel ilmiah ini ditulis menggunakan pendekatan studi literatur yang berusaha mengidentifikasi faktor-faktor yang mempengaruhi hasil. Hasil penelitian menunjukkan (1) Peran Brand Ambassador berpengaruh positif terhadap keputusan pembelian (2) Peran Brand Ambassador berpengaruh positif terhadap minat beli.
Artificial intelligence innovation in healthcare: Relevance of reporting guidelines for clinical translation from bench to bedside
Authors: Teo Zhen Ling , Kwee Ann , Lim John CW , Lam Carolyn SP , Ho Dean , Maurer-Stroh Sebastian , Su Yi , Chesterman Simon , Chen Tsuhan , Tan Chorh Chuan , Wong Tien Yin , Ngiam Kee Yuan , Tan Cher Heng , Soon Danny , Choong May Ling , Chua Raymond , Wong Sutowo , Lim Colin , Cheong Wei Yang , Ting Daniel SW
Published: April 2023

Artificial intelligence (AI) and digital innovation are transforming healthcare. Technologies such as machine learning in image analysis, natural language processing in medical chatbots and electronic medical record extraction have the potential to improve screening, diagnostics and prognostication, leading to precision medicine and preventive health. However, it is crucial to ensure that AI research is conducted with scientific rigour to facilitate clinical implementation. Therefore, reporting guidelines have been developed to standardise and streamline the development and validation of AI technologies in health. This commentary proposes a structured approach to utilise these reporting guidelines for the translation of promising AI techniques from research and development into clinical translation, and eventual widespread implementation from bench to bedside.

Keywords: Artificial intelligence, clinical translation, digital innovation, guidelines
The Investigation of the Use Red Beet Powder (Beta Vulgaris) As A Natural Colorant on Color and Antioxidant Properties of Heat Treated Sucuk
Authors: SERTDEMİRCİ Ömür , GENÇCELEP Hüseyin
Published: April 2023

The purpose of this study was to assess red beet as a natural colorant in heat treated sucuks and to investigate the effect of red beet on some quality characteristics of heat treated sucuks during 30 d of cold storage. Red beet was prepared as a powder and a substitute with sodium nitrite (nitrite 50 and 100 ppm) at 1% levels in heat treated sucuks. Both treatment and storage periods had significant (P
Surface Structural–Phase Modification of Structural Steels during Gas Nitriding
Authors:   Candidate of Technical Sciences, Acting Professor, Karshi Engineering Economics Institute, Eshkabilov Kholikul Karshievich
Published: April 2023

The formation of a composite nitride layer in an ammonia atmosphere with the addition of carbon– and oxygen–containing gases during gas nitriding is considered. The conditions for the formation of cementite during nitriding of steel and the influence of carbon in the matrix on the release of cementite are given. After oxidation of the nitride layer, modified nitride compositions with stable gradient structural–phase states were obtained.
Implementation of Criminal Sanctions to Sexual Violence with Under Children (Case Study of Child Abuse in Makassar)
Authors:   Faculty of Law, Wijaya Kusuma Surabaya University, Subagiyo Dwi Tatak ,   Jl. Dukuh Kupang XXV No. 54 Post Code 60225, Sulistiyo H. ,   Faculty of Law, Wijaya Kusuma Surabaya University; Jl. Dukuh Kupang XXV No. 54 Post Code 60225
Published: April 2023

The study entitled Application of Sanctions Against Crimes Against Sexual Abuse of Children Under Age aims first to find out and understand what factors cause children to commit sexual violence. Secondly to find out, understand and analyze the application of sanctions for children who commit sexual violence according to the Criminal Justice System for Children. The research method used in this thesis uses a normative research method which is a study conducted by examining all laws and regulations relating to the problems (legal issues) encountered. Based on the results of the study it can be concluded First: that the cause of children can commit acts of sexual violence is due to environmental factors around them because children are easily affected and technological factors that are rapidly developing technology can greatly affect children in committing sexual violence. Second: the application of sanctions for children must be prioritized diversion withjustice restorative that involves all parties ranging from perpetrators, victims, parents and law enforcement officials and when the diversion withjustice efforts restorative do not produce results and an agreement to eat criminal sanctions (Ultimatum Remidium) is the last resort.
Denpasar City Branding as Tourism Development Strategy: Law Branding Aspect Point of View
Authors:   Tourism Department Politeknik Negeri Bali, Indonesia, Bagiastuti Ni Ketut
Published: April 2023

One of the tour programs that have gained popularity for tourists in Bali is Denpasar City Tour. Denpasar is typically able to deliver persistence of heritage site in Gajah Mada and uniqueness of Badung and Kumbasari Market as places of interests, so it make this city as one of well-known places of interest, especially for its distinctive culture. Tourists’ visit throughout the year make possible creation of small scale business for the city residents. This potential is strengthened by the motto of the city “Sewaka Dharma” or Serving is Duty. Therefore, it is really required law enforcement in order to promote the philosophy of its motto that inspire the people passion in creating a competitive advantage of Denpasar city branding. The aforementioned regulation is Law Number 15 of 2001 that can regulate it.
A Study of the Effect of Family Relation (Parent’s Acceptance and Rejection) of Physically Handicapped Adolescent Boys and Girls on Self – Actualisation
Authors:   Research Scholar, RDVV Jabalpur, Tulip 142, Signature 360, Barrai, Bhopal, Madhya Pradesh, Paliwal Archana , Patel Rahul ,   Assistant Professor, Govt. Autonomous Mahakoshal Arts and Commerce College, Pachpedi, South Civil Lines, Jabalpur, Madhya Pradesh, Murhar Vaibhav ,   Indipendent Researcher, Tulip 142, Signature 360, Barrai, Bhopal, Madhya Pradesh, Nigam B. ,   Retired Counselor, Govt. College of Educational Psychology and Guidance, Jabalpur (M.P), 103, Pragati Height Apartment, Gupteshwer Ward, Mahanadda, Jabalpur, Madhya Pradesh
Published: April 2023

The investigation focused on effect of family relation on self - actualization of physically handicapped adolescent boys and girls. 240 boys and girls selected on the basis of family relation through multistage sampling in each group are compared through analysis of variance. Significant effect of parent child relation & personality variables is noted.
Implementing Collaborative Project and E-Portfolio in an Online Graduate Course: A Case Study
Authors:   Department of Health Sciences, The University of Arizona Global Campus, Chandler, AZ, USA, Lu Hwangji S. , Gustavus Brandy V. ,   Department of Health Sciences, The University of Arizona Global Campus, Chandler, AZ, USA
Published: April 2023

The ability to work in teams is an imperative competency in today’s complex healthcare delivery system. Collaborative learning allows students to cultivate teamwork, communication, critical thinking, and problem-solving skills. Collaborative learning activity is an essential pedagogical approach to prepare students to meet the need of the healthcare workforce. This paper presents a research study in which a collaborative project was implemented in a redesigned healthcare administration course in an online graduate program. The objectives of this study were to evaluate the effectiveness of this revised course and uncover solutions to improve the implementation of the collaborative project and the usefulness of this course. Students’ perceptions of completing a collaborative project and other learning activities such as ePortfolio were explored. Even though some students enjoyed collaborating with their teammates, other students did not like the collaborative project. The barriers to a successful collaborative project discovered in this study were also revealed in prior empirical studies. Limitations of this research were also presented. The recommendation was proposed for better integration of collaborative projects into the curricula of a program.
Cytotoxic Responses of Pancreatic Cancer Cell Line to Bitter Leaf (Vernonia Amygdalina), Tomato (Solanum Lycopersicum) and Coconut (Cocos Nucifera) Milk Extracts
Authors:   Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria, Elijah Joshua Parker , Chukwuemeka Anorue Eleazar ,   Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
Published: April 2023

This work is primarily designed to determine, through cell lines, the cytotoxic responses of pancreatic cancer cell (PANC-1) to reconstituted lyophilized extracts of coconut milk, bitter leaf and tomato with a view of evaluating the anticancer properties of these extract. The cytotoxicity analysis was performed on the extracts using the MTT assay method as previously described on pancreatic tumour (PANC-1) cell lines . The cytotoxicity studies showed concentration and dose-dependent decrease in cell viability of pancreatic cancer cell line (PANC-1) to the three lyophilized extracts of coconut milk, bitter leaf and tomato. Bitter leaf aqueous extract was significantly the most cytotoxic to the cancer cells followed by coconut and lastly tomato extracts. The cytotoxicity of coconut milk compared with tomato and bitter leaf to PANC-1 increased in the order of bitter leaf > coconut milk > tomato.
HUSK CHARCOAL MAKING TRAINING WITH CARBONIZATION MACHINE DURING COVID-19 TO IMPROVE COMMUNITY WELFARE IN SUKOHARJO REGENCY
Authors: Sriyanto Sriyanto , Rahmad Rahmad , Wartiono Totok , Suhartoyo Suhartoyo
Published: April 2023

The COVID-19 pandemic has changed all social activities in the community. The community is required to comply with health protocols by maintaining a distance between one person and others (Social distancing) and even a closure of activities that occur in an area (Lockdown) resulting in all activities being completely stopped, whether school, office or business activities in the community. Community activities that have changed due to saturation have made people have the idea of ​​growing ornamental plants. This activity resulted in the demand for growing media to increase, resulting in the supply of plant traders becoming scarce. Pak Harno's Flower Kiosk whose address is at Jl. Raya Jlopo, Hamlet III, Gedangan, Kec. Grogol, Sukoharjo Regency, Central Java is also the impact of the scarcity of plant media in the form of roasted husks. On the basis of this problem Community Service Activities held activities in the form of making appropriate technology tools, namely roasted rice husks which will be donated to partners. donating only tools but also providing training supplies for making roasted husks to partners, training in packaging manufacture and product packaging. From this activity the activity implementation team produces outputs in the form of media publications and Community Service journal
ASSISTING THE INTEGRATION OF TECHNOLOGY AND ITS EFFECT ON STUDENTS' ATTITUDES IN DISTANCE LEARNING
Authors: Djamdjuri Dewi Suriyani , Kamilah Iil Hilyatul
Published: April 2023

Teaching and learning process can be easily conducted due to technological developments. The development and application of information technology is also beneficial for the world of education. The purpose of this study is to assist in the integration of technology and its influence on students' attitudes in distance learning during the Covid 19 pandemic. The method of conducting this report is qualitatively descriptive study and the implementation of the service is carried out with two stages, that is the first is mentoring and the second is data retrieval through interviews and questionnaires addressed to students. The results of the implementation of this assessment show that there are many technological concerns about student attitudes, and technology can affect students' attitudes positively or negatively. Among the positive influences of technology on students are that it can increase creativity in using technology, feel more curious about technology and can affect the attitude of cooperation in student self-development. As for the negative impact that  affects students, students find it quite difficult to understand the material provided by the teacher.  The results of the assistances showed that the positive impact was more dominant than the negative impact experienced by students.
TRAINING MOTIVASI BELAJAR MATEMATIKA BERBASIS THINKING SMART GAME PADA SISWA MI MULTIPLE SARINA
Authors: Hasanah Nur , Ambarsari Ida Fitriana , Surur Miftahus , Darmawati Lusi Endang Sri , Rakhman Fathor
Published: April 2023

Pembelajaran matematika pelajaran yang membutuhkan logika dan daya nalar yang baik maka dibutuhkan inovasi-inovasi pembelajaran yang dapat meningkat motivasi siswa. Pembelajaran matematika yang diajarkan secara monoton yang dilakukan oleh guru dapat membuat siswa merasa jenuh dan akhirnya membuat siswa malas dalam belajar. Selain membuat siswa malas belajar terdapat faktor lain yang sudah muncul melalui presepsi mereka sendiri yaitu yang menganggap matematika sebagai pelajaran yang relatif sulit dan membentuk kesan dan pengalaman secara negatif terhadap matematika yang umumnya dapat berdampak buruk baik bagi motivasi belajar matematika maupun penyesuaian akademik di sekolah. Namun, di sisi lain matematika dianggap penting karena perannya sebagai prediktor yang kuat bagi anak untuk memasuki sekolah formal dibanding keterampilan emosi dan sosial. Kegiatan pengabdian kepada masyarakat dalam bentuk kegiatan training dalam peningkatan Motivasi Belajar Matematika Berbasis Thinking Smart Game pada Siswa MI Multiple Sarina untuk membantu siswa agar lebih termotivasi dalam belajar matematika dalam metode yang digunakan dalam kegiatan pelatihan ini yaitu Metode ekspositori, Metode diskusi, Metode praktek dari hasil pengabdian yang didapat dari hasil pengisian angket respon siswa didapat bahwa terdapat 90% siswa yang senang belajar matematika dan masih terdapat 10% siswa yang tidak senang belajar matematika