bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiological Study of Femoral Head Osteonecrosis
Authors: Patrascu Alexandru , Savin Liliana , Mihailescu Dan , Grigorescu Victor , Grierosu carmen , Mihai Dana Nicoleta , Stana Ademir Horia , Botez Paul
Published: February 2020

In recent years, there has been an increase in the number of studies on the etiology of femoral head necrosis. We retrospectively reviewed all patients diagnosed with aseptic necrosis of the femoral in the period of 2010-2015. We recorded a total of 230 cases diagnosed with aseptic necrosis of the femoral head, group was composed of 65.7% men and 34.3% women, risk factors identified was 19.13% (post-traumatic), 13.91% (glucocorticoids), 26.52% (alcohol), 3.47% (another cause) and in 36 95% of the cases no risk factors were found. The results of the study based on the type of surgery performed on the basis of stages of disease progression, 8 patients (3.48%) benefited from osteotomy, 28 patients (12.17%) benefited of bipolar hemiarthroplasty prosthesis and 188 patients (81.74%) benefited of total hip arthroplasty. Osteonecrosis of the femoral head is characteristic to young patients between the age of 30-50 years old. Predisposing factors, alcohol and corticosteroid therapy remains an important cause of the disease. Total hip arthroplasty remains the best option for the patients with osteonecrosis of the femoral head.
Age Influence in the Prognosis of Bacterial Secondary Peritonitis
Authors: Firescu Dorel , Serban Cristina , Nechita Aurel , Dumitru Mihaela , Rebegea Laura
Published: February 2020

Today the age of 60-65 years old is considered the seniority threshold. The structural, functional and metabolic alterations which occur following to the aging process determine an exacerbation of the impact which any aggression will have on the body. This retrospective study analyses a group of 245 patients with severe peritonitis, which had been hospitalized and treated in Surgery 2nd Clinic of the Sf. Apostol Andrei Emergency Clinical Hospital in the period 2007-2016. The median age 54 years old [range 30-95]; 68 patients (27.76% of cases) were ] 65 years old (65+) and 177 patients (72.24% of cases) with age between [ 65 years old (65-). Out of the results obtained, it is obvious the impact of age in the evolution and prognosis of bacterial peritonitis.
Immunohistochemical Methods to Diagnose Atraumatic Spleen Rupture in Feline Infectious Peritonitis of Tiger (Panthera tigris)
Authors: Horhogea Cristina , Floristean Viorel , Lazar Mircea , Cretu Carmen , Solcan Carmen
Published: February 2020

A body of an eight-year-old male tiger, originated from a Romanian zoo was brought in for pathological diagnosis to the Faculty of Veterinary Medicine. The necropsy revealed uveitis, sero-hemorrhagic peritonitis, fatty liver and kidney, haemorrhagic-necrotic lesions on the spleen, catarrhal enteritis, serous pericarditis and pulmonary anthracosis. Amyloidosis was found in the intestine, liver, lungs and kidney and spleen, associated with necrosis and the presence of hematin blocks. Positive macrophages for feline coronavirus (FCoV) were highlighted by immunohistochemistry in liver, kidney, lungs and intestinal lamina propria. Immunofluorescence (IF) examination of pericardial and peritoneal fluid was positive for feline infectious peritonitis (FIP). Confirmation of FIP coronavirus was made by Reverse Transcription Polymerase Chain Reaction (RT-PCR). The systemic amyloidosis and the presence of hematin in peritoneal fluid and spleen parenchyma are lesions that were not mentioned as specific for FIP until now.
Assessment of a Maslinic Acid Derivative and its Metabolite in Rat Blood by Liquid Chromatography Coupled with Mass Spectrometry
Authors: Pavel Ioana Zinuca , Dehelean Cristina Adriana , Farczadi Lenard , Muntean Dana Maria , Vlase Laurian , Danciu Corina , Csuk Rene , Birsasteanu Florin , Muntean Danina Mirela
Published: February 2020

A new rapid high-throughput liquid chromatography coupled with tandem mass spectrometry method (LC-MS/MS) was developed for the blood assessment of a maslinic acid derivative (Benzyl (2a, 3b) 2,3-diacetoxy-olean-12-en-28-amide) and its metabolite. Separation was performed using a Zorbax SB-C18 column with a mobile phase composition of methanol and 0.2% formic acid in water (78:22, v/v) in isocratic flow, with a flow rate of 0.6 mL/min. Detection was performed by multiple reaction monitoring (MRM) mode, monitoring the transitions 338.3; 526.6; 544.6; 527.5; 545.5 m/z derived from 646.6 m/z for the maslinic acid derivative and 409; 338.3; 203; 205; 526.5 m/z derived from 562.6 m/z for its metabolite, using atmospheric pressure chemical positive ionisation source. Single-step protein precipitation with methanol was used for preparation of rat blood samples. The method was validated with respect to selectivity, linearity (r ] 0.9937), within-run and between-run precision (CV [ 12.0%) and accuracy (bias [ 7.9%) over the ranges of 20.5 - 656 ng/mL blood for maslinic acid derivative, and 20 - 640 ng/mL blood for maslinic acid derivative metabolite. The analytical method is simple, fast, selective and is suitable for bioanalysis of maslinic acid derivative and its metabolite from rat blood.
Hydrogenolysis of Glycerol in Gas Phase on Cu-Cr Mixed Oxide Catalyst Doped with Ni
Authors: Georgescu Vasile , Panaitescu Casen , Bombos Mihaela , Bombos Dorin
Published: February 2020

Hydrogenolysis of glycerol was conducted on catalyst of the type mixed oxide of Cu-Cr doped with NiO on g-Al2O3. The prepared catalyst was analyzed by XRD, IR and TPR. Catalytic tests were carried out on a laboratory plant in continuous flow system on a reactor equipped with heating mantle, at molar ratio of glycerol / hydrogen of 1/300, glycerol volume hourly space velocities 1000s-1, temperatures 200-220oC and pressures 3-5 bar. The main reaction products identified were propylene glycol and hydroxyacetone. Glycerol conversion increases with temperature and pressure on ranges of parameters studied. Selectivity to propylene glycol increases with increasing of temperature and pressure and the selectivity to hydroxyacetone decreases with increasing of temperature and pressure on the variation range of the parameters studied.
Resistance Profile of the Isolated Bacterial Stems in Invasive Infections in Three Hospitals in the South-East of Romania
Authors: Tiutiuca Carmen , Draganescu Miruna , Iancu Alina Viorica , Chesaru Bianca Ioana , Arbune Manuela , Maftei Nicoleta , Popescu Eugenia
Published: February 2020

The purpose of this study was to determine the etiologic range of the invasive infections and the profiles of resistance to antibiotics in the isolated stems from patients hospitalized in the Sf. Apostol Andrei Emergency Hospital Galati; Sf. Cuv. Parascheva Hospital of Infectious Diseases Galati and Sf. Ioan Hospital for Children of Galati. We analysed 4029 blood cultures in the period 01.01.2014-30.12.2016. Among the bacterial stems frequently isolated were: coagulase-negative staphylococci, S. aureus, E. coli and Klebsiella pneumoniae. The level of resistance to antibiotics increased, expressing resistance phenotypes of clinic and epidemiologic importance, among which we notice the increased incidence of the stems MRSA (28.95%) and MRS (56.07%), and the production of ESBL in E. coli (30%) and Klebsiella pneumoniae (47%).
Study Regarding Correlation of the Methanol Intoxication and Tissues Necrosis
Authors: Knieling Anton , Calipsoana Matei Mioara , Bulgaru Iliescu Diana , Manea Cristiana , Diac Madalina , Chistol Raluca Ozana , Furnica Cristina
Published: February 2020

Methanol intoxication is a potentially fatal medical condition associated with basal ganglia and subcortical white matter necrosis. The authors present the case of a 34 years-old female with putaminal necrosis and haemorrhagic stroke secondary to methanol intoxication. The patient was hospitalized in the intensive care unit with severe metabolic acidosis and bilateral blindness after ingesting an unspecified amount of methanol. Computed tomography (CT) examination performed at hospital admission revealed a hypodense, inhomogeneous aspect of lenticular nuclei with ischemia in observation. In the 18th day post-ingestion the patient went into deep coma and a new CT examination was performed revealing an intracerebral hematoma involving the right lenticular nucleus, right external and extreme capsule, and right insula with uncal herniation. Neurosurgical decompression was attempted with unfavourable outcome and exitus. Necropsy examination revealed bilateral lenticular necrosis and a hematoma between the base of the right lenticular nucleus and insular cortex with destruction of the claustrum, external and extreme capsules. Methanol poisoning (mostly accidental) is not uncommon in our country and its metabolite, the formic acid, is a potent central nervous system toxin. Bilateral lenticular necrosis is a typical finding in methanol intoxication due to formic acid accumulation with decrease in mitochondrial adenosine triphosphate (ATP) synthesis responsible for cellular toxicity.
Biostatistical Analysis and Possible Forecasting of Relationship Between Uric Acid and Specific Laboratory Tests in Cases of Gouty Arthritis
Authors: Duse Adina Octavia , Berceanu Vaduva Delia , Nicolov Mirela , Trandafirescu Cristina , Berceanu Vaduva Marcel , Cevei Mariana , Heghes Alina
Published: February 2020

Acute gouty arthritis represents an inflammatory response to microcrystals of monosodium urate that precipitate in joint tissues from supersaturated body fluids or are shed from preexisting articular deposits [1]. Gout is a metabolic disease characterized by recurrent episodes of arthritis associated with the presence of monosodium urate crystals in the tissue or synovial fluid during the attack.These forms of crystal-induced arthritis usually affect peripheral joints, including knee, ankle, wrist, and metacarpophalangeal and metatarsophalangeal joints. All of them may be associated with other inflammatory, endocrine diseases [2]. The present study was done to highlight the relationship between increased levels of uric acid and specific laboratory tests in order to possible forecast development of further disease in patients with gouty arthrithis.The present study was done on 34 patients hospitalized in Felix Hospital of Rehabilitation in 2015-2016, with age between 44 and 74, having the main diagnosis of gouty arthritis.We studied the following laboratory tests:urea and other related analysis, like uric acid, creatinine, cholesterol, glutamate pyruvate transaminase and glutamate oxalate transaminase.
Identifying Etiologic Agents in Acute Diarrhea in Children. Therapy with Antibiotics or Probiotics?
Authors: Totan Maria , Antonescu Elisabeta , Grigore Nicolae , Cernusca Mitariu Maria Mihaela , Cernusca Mitariu Sebastian Ioan , Serb Bogdan Horatiu
Published: February 2020

In infants and toddlers, acute diarrhea is the most common gastrointestinal disorder. Recent literature has shown that viruses are the most common cause and of these, Rotavirus is a major causative agent of diarrhea in children under five years old, representing a major cause of mortality in this age. Since there is no etiologic treatment for viral diseases, hydro-electrolytic rebalancing is the standard therapy and vaccination is the most effective way to prevent these diseases. The study is a retrospective one and aims at establishing the etiology and correlation with origin environment (urban or rural) of children with acute diarrhea in Sibiu area. The study included 3135 children aged 1 month - 18 years old, admitted to the Pediatric Clinic, Sibiu, between January 1, 2014 - December 31, 2016. Laboratory tests were used to determine viral and /or bacterial etiology of acute diarrhea. Viral etiology was the most common, being confirmed in 34.1% of cases, and the bacterial one was confirmed in 10.8% of cases, of which the most frequent etiological agent involved was Campylobacter jejuni (40.0%). The most frequent aetiology of acute diarrhea in children in the Sibiu area are the viral infections, Rotavirus being the first, and of bacterial aetiology, rare in frequency, Campylobacter jejuni is the leader followed by Salmonella spp., and Shigella spp. Children in urban areas were more frequently affected by acute diarrhea than those in rural areas, unlike data from the literature.
Evaluation of Metal Contents in Correlation with Phytosanitary Treatments at Vineyard
Authors: Mihai Oana , Pantea Octav , Popovici Daniela Roxana , Gheorghe Catalina Gabriela
Published: February 2020

The present work aims with the evaluation of copper, manganese and zinc concentrations (mobile forms) from vineyard soil before and after phytosanitary treatment with Curzate Manox and Dithane M-45 compounds, during and after remanence period. Different vineyard soils types were collected at 0-20 cm and 20-40 cm depths. Flame Atomic Absorption Spectroscopy (FAAS) method was used for measurements of the micronutrients. The soil samples were analyzed after 5 and 21 days after treatment application. Since copper is mainly accumulates in the upper layer following fungicidal sprays application, high levels of copper concentrations are obtained. The soil samples exhibits different behavior in terms of manganese and zinc contents. Manganese and zinc levels are classified as medium in the beginning of the experiment (Mn-M0 and Zn-M0), whereas these levels increased in the soil samples (at moments M1- 5 days and M2- 21 days after treatment). This behavior can be due to the Mancozeb decomposition, knowing that Mancozeb decomposes in the pH range 5-9 and it remains short time into the soil.
In vitro Three Dimensional Scaffold-free Construct of Human Adipose-derived Stem Cells in Coculture with Endothelial Cells and Fibroblasts
Authors: Berea Grigore , Balan Gheorghe Gh. , Sandru Vasile , Sirbu Paul Dan
Published: February 2020

Complex interactions between stem cells, vascular cells and fibroblasts represent the substrate of building microenvironment-embedded 3D structures that can be grafted or added to bone substitute scaffolds in tissue engineering or clinical bone repair. Human Adipose-derived Stem Cells (hASCs), human umbilical vein endothelial cells (HUVECs) and normal dermal human fibroblasts (NDHF) can be mixed together in three dimensional scaffold free constructs and their behaviour will emphasize their potential use as seeding points in bone tissue engineering. Various combinations of the aforementioned cell lines were compared to single cell line culture in terms of size, viability and cell proliferation. At 5 weeks, viability dropped for single cell line spheroids while addition of NDHF to hASC maintained the viability at the same level at 5 weeks Fibroblasts addition to the 3D construct of stem cells and endothelial cells improves viability and reduces proliferation as a marker of cell differentiation toward osteogenic line.
Research Regarding Apparent Digestibility of Selected Hybrid Mulberry Leaf Chemical Content
Authors: Dolis Marius Gheorghe , Boisteanu Paul Corneliu , Simeanu Daniel
Published: February 2020

During the growth of silkworm larvae study, also was done a research which aimed to determine the chemical composition and the digestibility of mulberry leaves from a Romanian Selected Hybrid. The results showed that advancing in the vegetation stage at the same time with different periods of the silkworm larvae�s growth, the mulberry leaves experience an aging process being noticed through its quality decreasing from chemical composition point of view. So, for example, the CP which was in average 20.78�0.627% (from DM), decreased during the study with 2.87%; while the CF had an average of 18.10�0.271%, (from DM) increased with 1.47%. Accordingly with this, to the majority of nutrients from mulberry leaves, except the crude fiber was noticed a continuous digestibility decreasing throughout larval growth period. The nutrients digestibility from the leaves registered a value of 58.45%.
A Risk Assessment of Clostridium Difficile Infection after Antibiotherapy for Urinary Tract Infections in the Urology Department for Hospitalized Patients
Authors: Grigore Nicolae , Totan Maria , Pirvut Valentin , Cernusca Mitariu Sebastian Ioan , Chicea Radu , Sava Mihai , Hasegan Adrian
Published: February 2020

Antibiotherapy is the treatment of choice for the urinary tract infections in hospitalized urological patients. Antibiotic associated diarrhea (ADD) caused by the Clostridium difficile cytotoxin producer represents one of the most severe side effects of the antibiotic treatment. It is important to evaluate the risk factors for a hospitalized patient to develop a C. difficile healthcare associated infection during hospitalization in order to put in practice effective preventive measures. The aim of the study is to analyzed the risk factors associated with the demographic status: age, sex, and also risk factors related to healthcare conditions: use of antibiotics (number, type, duration of treatment), other significant medication taken prior to the onset of diarrhea (histamine-2-receptor antagonists and proton-pump inhibitors, comorbidities, possible contamination from other in-patients who developed ADD in the same period and data about in-hospital mortality.
Methylene Blue Video Contact Endoscopy Enhanced with SPIES Filters in Early Detection of Malignancies of the Vocal Fold
Authors: Hainarosie Razvan , Zainea Viorel , Hainarosie Mura , Pietrosanu Catalina , Ionita Irina
Published: February 2020

Methylene blue video contact endoscopy was imagined for the first time in the early �70s by a gynecologist named Hamou. He was the first one to perform contact colposcopy using methylene blue staining. Because of the poor medical optic technology at that time the method was abandoned. Prof. Mario Andreea and Oscar Diaz preformed in 1994 the first video contact endoscopy of the vocal fold. We propose a new way to enhance the video contact endoscopy�s power to detect early malignancies of the vocal fold using SPIES software filters. The method will be critically analyzed.
Fatal Ethylene Glycol Intoxication Secondary to Accidental Ingestion
Authors: Furnica Cristina , Knieling Anton , Damian Simona Irina , Diac Madalina , David Sofia , Bulgaru Iliescu Diana , Sandu Ion , Iov Catalin Jan
Published: February 2020

Ethylene glycol intoxication is potentially fatal and associated with typical clinical, laboratory and histopathological findings. The authors present the case of a 57-year-old male with a history of chronic alcoholism and who accidentally ingested approximately 1 litter of antifreeze solution. The patient was discovered comatose in his house and addressed to the emergency department with a Glasgow coma score of 3, severe metabolic acidosis, acute renal failure, atrial fibrillation and liver dysfunction. Despite reanimation manoeuvres and haemodialysis for 2 h the patient deceased 5 h after hospital admission. Necropsy examination revealed a stomach with oedematous walls, mucosa erosions and signs of bleeding together with a disorganised, granular single kidney with unidentifiable corticomedullary border. Histopathological examination displayed typical findings in the kidney such as autolytic changes of the epithelium and abundant calcium oxalate crystals in the lumen of the proximal tubules. Ethylene glycol intoxication is frequent in our country and its metabolites glycoaldehyde, glycolic acid, glyoxylic acid and oxalic acid are responsible for the severe metabolic acidosis and formation of calcium oxalate crystals in various organs and leading to severe multiple organ dysfunction and death. Forensic pathologists should be aware of clinical and biological manifestations as well as of typical histopathological findings as ethylene glycol is commonly ingested accidentally or used in homicidal/autolytical attempts.
The Evaluation of the Levels of Greenhouse Gases due to Activities Carried Out on a Livestock Farm
Authors: Danciulescu Valeriu , Vasile Andrei , Pascu Luoana Florentina , Stanescu Bogdan , Nicolescu Ileana
Published: February 2020

The paper presents the results of tests carried out on a Romanian farm with the purpose of assessing greenhouse gas (GHG) emissions specific to agricultural activities. GHG emissions from the agricultural sector come mainly from the livestock sector, manure management, land cultivation and fertilization.
The tests carried out mainly focused on the CO2 , CH4 and N2O emissions generated from related manure storage activities as well as the emission level identified in animal shelters. For a correct interpretation of the results obtained, at the same time with the measurement of the GHG concentration, the weather parameters were measured: temperature, humidity and wind direction. The results obtained revealed the presence of these compounds in the air in the animal shelters and in the ambient air (CO2 and CH4) in concentrations that are in the range identified in similar studies around the world. The pollutant dispersion in the air leads to a reduction in the pollutant concentration with increasing distance from the observed source as well as the measurement points at 50, 100 and 500 m, that reaches values below the detection limit of the instrument for CH4 and N2O, whereas in the case of CO2 it reaches the level of the usual concentration in the ambient air.
Thermal Decomposition of Some Sol-Gel Precursors for Mesoporous TiO2-Based Thin Films for Chemorezistive Environmental Sensors
Authors: Dediu Violeta , Musat Viorica , Jurca Bogdan , Cristea Nicolae Ionut
Published: February 2020

This paper presents a comparative study on the thermal decomposition in air and FTIR analyses of complex sol-gel precursors used for the deposition of three titania based mesoporous thin films: TiO2, Nb-doped TiO2 and carbon nanotubes (MWCNT)-doped TiO2. The effect of doping with Nb or adding MWCNT on the thermal decomposition of titanium isopropoxide-based precursor and crystallization of TiO2 was investigated through thermogravimetric analysis (TGA), differential thermal analysis (DTA), and Fourier Transform Infrared (FTIR) data. TG-DTA results showed two main exothermic peaks were observed in all samples for the temperature range 280-300 oC and 429-444 oC, corresponding to isopropoxide oxidative decomposition and anatase crystallization. In case of Nb doped TiO2 an oxidative decomposition of Nb ethoxide appears at 198 �C. The acidified MWCNT are thermally stable up to 500�C. Doping TiO2 causes peaks shift to higher temperatures. Also, the effect of heating rate on thermal decomposition for precursors was studied. FTIR analyses were conducted on precursor systems thermally treated at different temperature to track the chemical transformations during the films formation.
New Study Concerning the Biodegradation of Dimethoate, Chlorpyrifos and Chlorfenvinphos in some Medicinal Plants
Authors: Puiu Diana , Galaon Toma , Cruceru Liliana , Niculescu Marcela , Mihalache Madalina , Pascu Luoana Florentina , Popescu Mariana
Published: February 2020

Herbal drugs are widely used in pharmaceutical industry due to their beneficial effects on human health. The current research was carried out to evaluate the organic pollutant degradation in the flower part of the plant after a foliar application of pesticides. Also, based on the fact that selected pesticides are highly toxic to bees, it is important to monitor the removal rate of the pollutant. Under laboratory conditions, the marigold and French flowers (Calendula Officinalis and Tagetes Patula) were spiked with a mix of organophosphorus insecticide, dimethoate, chlorpyrifos and chlorfenvinphos, where the first two substances are still used on Romanian territory. The samples were extracted at different time moments over 300 min after sprayed treatment in order to evaluate the concentration in flower. The analytes were quantified by using gas chromatography with flame photometric detection (GC-FPD) technique. The developed method ensures the quality and comparability of analytical results, with a good sensitivity in determining the analytes over the concentration range 5-250 �g/L.
Disease Free Margins Assessment Using Enhanced Methylene Blue Video Contact Endoscopy with SPIES Filters in Vocal Fold Malignancies
Authors: Hainarosie Razvan , Zainea Viorel , Hainarosie Mura , Pietrosanu Catalina , Ionita Irina
Published: February 2020

Vocal fold carcinomas represent a pathology that has an important incidence. Recent studies showed that 70% of the dysplastic lesions can skip the phases of mild and severe dysplasia directly to carcinoma. For that reason early detection of a malignancy of the vocal fold is mandatory. If the lesion is discovered in an early stage it must be aggressively treated using CO2 LASER surgery and disease free margins must be obtained. Because frozen sections are not always available in all medical centers we are proposing a new protocol to assess disease free margins during CO2 LASER assisted laryngoscopy. Methylene blue contact endoscopy is not a new method, as it was introduced in laryngology by professors Oscar Diaz and Mario Andreea in 1994. We are proposing a protocol designed to assess disease free margins using an enhanced video contact endoscopy with SPIES software filters. The SPIES filters technology is a relatively new technology proposed by Karl Storz in 2013. A critical analysis of the method will be done comparing the results with paraffin histopathology exam.
Unilateral NMR and Micro DSC Study of Artificially Aged Parchments
Authors: Sendrea Claudiu , Badea Elena , Adams Alina
Published: February 2020

New and artificially aged parchments were studied by unilateral NMR and micro DSC. Samples were obtained by exposing new parchments to 80 �C and alternate 40 and 80% relative humidity for increasing times up to 32 days. The impact of accelerated ageing was assessed by measuring both the proton transverse relaxation times (T2eff) and thermodynamic parameters associated with thermal denaturation of fibrillar collagen. Depending on the ageing time, significant structural changes correlated with thermal stability and collagen heterogeneity were observed, in good agreement with changes in phase composition and relaxation times. The results suggest two ageing regimes depending on the balance between the two main processes which drive the behavior of parchments during thermal ageing, i.e. thermally induced cross linking and thermal destabilization and denaturation.
The Contribution of Histochemical and Immunohistochemical Techniques in Assessing the Proliferative Capacity and Prognosis for Renal Cell Carcinoma
Authors: Puscasiu Daniela Anca , Tanasie Gabriela , Georgescu Marius , Tatu Romulus Fabian , Tatu Carmen Sofica
Published: February 2020

The drive to prolong life and to improve life quality in patients suffering from cancer forms of any kind means that, aside from the necessary treatment, prognostic evaluations are needed. In our present study we included 63 patients with renal cell carcinoma. The histological samples obtained in surgery were studied through the classical histopathology methods, histochemical and immunohistochemical techniques. The histological degree of tumor differentiation was assessed for all cases, falling within all 4 classification grades. The immunohistochemical reaction for PCNA (proliferating cell nuclear antigen) was performed, utilizing the PC 10-LSAB antibody through visualization with the LSAB-DAB kit. This was the method used for assessing the process of tumor proliferation. Subsequently, the histological degree of differentiation was correlated with the PCNA score. We anticipate a reserved prognosis for patients with a positive expression on most tumor cells, which represents a high PCNA score.
Analysis of Microstructure and Mechanical Properties of FSW Overlay Joints for Dissimilar Materials
Authors: Iordache Daniela Monica , Nitu Eduard Laurentiu , Plaiasu Adriana Gabriela , Botila Lia Nicoleta , Ducu Marian Catalin , Pasare Maria Minodora
Published: February 2020

Welding of Al and Cu materials by friction with active rotating element is of particular interest, being used in various branches of industry due to superior properties. The paper is centred on the analysis of microstructure and microhardness of the Cu-Al joint obtained by FSW. Optical and electron microscopy was used for the microstructure analysis and there was noticed the formation of a joint zone with a structure containing both Al and Cu. EDS analysis completes the microstructural analysis and confirms the presence of the two elements in the nugget zone. From the analysis of microhardness with the Vickers method it is noted an increase of hardness in the dissimilar welded joint zone (particularly in Cu) due to the achievement of a mixture of the anticlockwise rotational movement of the pin. FSW method proves to be a useful technique for joining dissimilar materials that are difficult to assemble with other conventional methods.
Effect of Treatment with Saline Solution (NaCl) on Rape Plants in Presence of the Hemp Shives
Authors: Cosarca Sanda , Rosca Ioana , Coman Alina , Nagy Bota Monica Cristina , Tanase Corneliu
Published: February 2020

The aim of this research was assessing the influence of hemp shives, like amendaments, in saline soils planted with rape (Brassica rapa L.). The growth and development assessing of rape plants in saline soils was achieved through biometric measurements for elongation and gravimetric measurements for the amount of biomass synthesized. Also, it was followed determination of the concentration of assimilating pigment (chlorophyll a, b, total carotenoid pigments) and protein content. It was found that adding hemp shives in soils with low salinity stimulated elongation and germination processes for rape. In soil with high salinity adding hemp shives determine an increase of biomass accumulation in all vegetative organs, comparative with the same salt concentration where we added the amendaments. Hemp shives can be recommended like natural amendaments for soils with high salt concentration.
Evaluation of Compressive Strength of Repaired Direct Composite Resin Restorations
Authors: Andrian Sorin , Pancu Galina , Topoliceanu Claudiu , Tofan Nicoleta , Stoleriu Simona , Iovan Gianina
Published: February 2020

The aim of the study was to evaluate and to compare the compressive parameters of repaired composite restoration when using different types of composite resins and a universal bonding agent as an intermediate layer. Aged micro-filled hybrid and nano-filled hybrid composite resins were chosen to simulate old restoration. The same micro-filled hybrid composite resin was used as a repair material. A universal bonding agent applied in etch-and-rinse and self etch strategies was used as an intermediate layer in restoration repair. Non-aged composite resins were considered as control. Compressive strength and compressive modulus were determined by evaluating the samples in a universal testing machine. Lower values of the tested parameters were recorded after aging both types of composite resin when compared to control. Higher values of compressive strength were recorded when nano-filled hybrid composite resin was repaired when compared to micro-filled hybrid composite resin. The strategy of universal bonding agent application as an intermediate layer did not influenced the compressive properties of repaired restoration.
Intranasal Oxytocin in Autism: Models, Pain and Oxidative Stress
Authors: Padurariu Manuela , Antioch Iulia , Ciobica Alin , Lefter Radu , Simion Laurentiu
Published: February 2020

There is an increased interest in the current literature in how relevant the administration of oxytocin, mostly by using its intranasal administration, could be in some neuropsychiatric disorders and especially in those manifesting a deficit at their sociability level. These aspects made the possible usage of oxytocin as extremely attractive for some management and treatment solutions in the autistic pathology. Thus, we are describing here some original data and current literature status on how oxytocin could help pathophysiological autistic manifestations in both animal models and human patients, by mainly focusing on some specific behavioural or pain manifestations and related oxidative stress status.
Biosorption of Cd(II) Ions from Aqueous Solution Onto Eggshell Waste Kinetic and equilibrium isotherm studies
Authors: Tonk Szende , Majdik Cornelia , Szep Robert , Suciu Maria , Rapo Eszter , Nagy Boldizsar , Niculae Alexandra Gabriela
Published: February 2020

Eggshell waste as adsorbent was successfully used for the removal of Cd(II) ions from model synthetic aqueous solutions. Batch biosorption studies were conducted in order to evaluate the effect of various parameters, such as: contact time and initial metal ion concentration. The changes in the morphological structure were evaluated by TEM and SEM analysis. The experimental isotherm data were analysed using Langmuir, Freundlich, Dubinin-Radushkevich, and Temkin isotherm equations, using regression analysis linear and non-linear form. Langmuir model was found to be in better correlation with experimental data (R2=0.99). Biosorption kinetics data were tested using pseudo-first-order, pseudo-second-order, intra-particle and liquid film diffusion models. Kinetics studies showed that the biosorption followed a pseudo-second-order reaction. Removal efficiencies up to 92 % and a maximum adsorption capacity of 8.2 mg/g Cd(II) were obtained experimentally and 7.14 mg/g Cd(II) were obtained from Langmuir isotherm model. The percentage of metal sorption (Ci=11 mg/L, E,(%)=92.42), EDS analyses, and bioconcentration factor were also calculated. The investigation findings suggested that the physical adsorption is controlling the adsorption rate. Results of this study indicate that eggshell waste can be effectively used for the removal of Cd(II) ions from aquatic environments. The process is feasible, reliable and eco-friendly.
Study on the Formation Mechanism and Sinterability of La1-x SrxCoO3-d (x = 0.1 - 0.3) Prepared by Mechanical Activation
Authors: Velciu Georgeta , Ianculescu Adelina Carmen , Melinescu Alina , Marinescu Virgil , Preda Maria
Published: February 2020

In this work it was studying evolution of the reactions that occur at the formation of La1-xSrxCoO3-� from mixtures of La2O3, Co3O4 and SrCoO3, prepared by mechanical activation. It was found that distributions of the particles sizes after mechanical activation are unimodal and narrow. Thermal analysis shows that the reactions that occur under the temperature of 1000oC are dissociation reactions of the raw materials or of intermediate compounds formed in the process of mechanical activation. The first compound found, starting from 1000oC was LaCoO3, whereas Co3O4 and CoO were observed as secondary phases. By measuring the apparent density of the thermally treated samples, a good tendency to sintering was noticed. SEM images and EDX analyses allowed to highlight the high sinterability of the samples.
The Synergistic Antioxidant Effect and Antimicrobial Efficacity of Propolis, Myrrh and Chlorhexidine as Beneficial Toothpaste Components
Authors: Lisa Elena Lacramioara , Carac Geta , Barbu Vasilica , Robu Silvia
Published: February 2020

Toothpastes containing different components which could have beneficial effects on oral health and the identification of better composition are always a research challenge. Our study aims are to evaluate the synergistic effect of propolis, myrrh, and chlorhexidine, separated and combined in some formulated toothpaste. To assess the electrochemical capacity by monitoring of physico-chemical parameters (pH conductivity), the mixture of these components in toothpaste into artificial saliva solution was performed in ambient medium and at 37oC. The antioxidant activity and the antimicrobial potential in vitro of toothpastes formulated against microorganisms that frequently colonize the oral cavity was performed also. It has been found that mixtures of chlorhexidine, propolis, and myrrh exhibit synergistic antioxidant activity with better potential than some commercial toothpaste, also the antibacterial activity shown that this activity is maintained in time against some strains.
Diclofenac Influence on Photosynthetic Parameters and Volatile Organic Compounds Emision from Phaseolus vulgaris L.Plants
Authors: Copolovici Lucian , Timis Daniela , Taschina Monica , Copolovici Dana , Cioca Gabriela , Bungau Simona
Published: February 2020

Diclofenac, both from human and veterinary consumption, may arrive in landfills or in the wastewater treatment plants, becoming an environmental pollutant. Therefore, we aimed to study the influence of diclofenac on plants growth and development. We chose as model plant the bean (Phaseolus vulgaris L.) that was watered with different concentrations of aqueous diclofenac solutions (0-0.4 g/L). The plants exhibited linear decreased values of net assimilation rates and stomatal conductance to water vapors with increased diclofenac�s concentrations. Emission of 3-hexenol was determined to scale up with diclofenac concentration, therefore this compound may be proposed as stress marker. Also in the emission of bean plants were detected 3 different monoterpenes (a-pinene, camphene and 3-carene), their concentration increasing with elevated concentration of diclofenac. We can conclude that diclofenac may affect the plants photosynthetic parameters and also might disturb the methylerythritol phosphate pathway (MEP) in plastids.
Specific Sialochemical and Sialometric Changes and Cariogenic Risk in Patients with Primary Sjogren`s Syndrome
Authors: Ancuta Codrina , Ghiorghe Cristina Angela , Chirieac Rodica , Ciocan Pendefunda Alice Arina , Iordache Cristina
Published: February 2020

The main aim of our study was to perform a biochemical analysis of the saliva and to assess potential impact on oral health, particularly cariogenic issues, in patients with salivary secretory dysfunction such as primary Sjogren�s syndrome (pSSj). Consecutive pSSj and healthy age-matched controls were prospectively assessed for (i) whole saliva flow rates (unstimulated, RFR, and stimulated, RFS), pH and composition; (ii) cariogenic scores - decayed, missing and filled tooth surfaces (DMFS index), Silnes and Loe bacterial plaque index (PI). Salivary flow rates were significantly lower in pSSj for both unstimulated and stimulated tests (p[0.05), with a drop in pH as compared to healthy controls (p[005). Abnormal inorganic and organic saliva composition was reported in all cases comprising higher sodium, lower potassium and chloride concentrations, higher amylase activity and lower total protein (p[0.05). Statistically significant higher cariogenic scores particularly DMFS, were demonstrated in all pSSj (p[0.05). In conclusion, patients with pSSj are at increased risk to develop cariogenic issues due to both quantitative and qualitative salivary changes.
Assessment of Biochemical Markers in Two Particular Cases with Maxilary Cysts
Authors: Pricop Marius , Olariu Tudor Rares , Motoc Marilena , Urechescu Horatiu , Pricop Cristiana , Banu Ancuta , Faur Alexandra , Gurban Camelia Vidita
Published: February 2020

Biochemical markers have been previously described as predictors of bone remodelling in dental disorders. Here we present 2 cases, diagnosed with inflammatory maxillary cysts in whom biochemical markers of bone remodeling have been evaluated. Clinical evaluations, radiological and laboratory tests, including histopathological examinations were performed in both patients. Laboratory test results indicated an activation of osteoblasts in both cases. Bone alkaline phosphatase (BAP) serum levels, as a marker for bone deposition, were significantly increased in both patients. In addition, differences in the cyst size and the tartrate-resistant acid phosphatase (TRACP-5b) test results have been noted in these cases. In the first case, with a cyst [ 1.5 cm in diameter, TRACP-5b serum levels were within the normal reference laboratory values, suggesting that the process of bone resorption may be slightly decreased or potentially lacking. In the second case, with a cyst ] 3 cm in diameter, TRACP-5b serum levels were 1.5 times higher than the upper limit of the normal reference laboratory values, suggesting that a process of osteolysis apparently occured. The two cases diagnosed with maxillary cyst presented differences in the size and the TRACP-5b test results. This suggest a possible correlation between TRACP-5b serum levels, bone resorption and the size of maxillary cysts. Further studies should be performed to confirm this hypothesis.
Systemic Lupus Erythematosus Flared up After Rifampicin During Active Pulmonary Tuberculosis
Authors: Postolache Paraschiva , Ianosi Edith Simona , Jimborean Gabriela
Published: February 2020

The present study describes a systemic lupus erythematous (SLE) flared up after Rifampicin during active pulmonary tuberculosis (TB). A 20-year-old female was hospitalized for cough, weight loss, and apical infiltrates. Microscopy from bronchial lavage confirmed TB. After 1 week of antituberculous treatment we noted diffuse purpura, oral/nasal ulcers, leukopenia, nephritis, antinuclear antibodies, low complement (criteria for SLE). We excluded Rifampicin and introduced immunosuppressive drugs and other reserve antibiotics for TB. Clinical status improved after 2 weeks and TB cured after 9 months. Rifampicin may flare up a subjacent unknown SLE. SLE is a risk factor for TB.
A Computational Study of a Prebiotic Synthesis of the Steroid Progesterone (A and B Rings)
Authors: Aylward Nigel
Published: February 2020

The magnesium ion metalloporphyrin complex is shown to bind the ligands propyne (p) and ethyne (e) on the metal or nitrogen pyrrole sites as a two site catalyst in their copolymerization. The order of addition of the monomers is (pepeeepee). The steroid ring D (pep) is formed first from the propyne adduct bound to the metal site and the but-diene adduct bound to the N-site. The optimal orientation of these adducts determines the β-orientation of the 17-substituent. Further reaction with hydroxyl radicals allows this to be a 17 β- acetyl substituent. Further addition of three ethyne monomers forms a N-tri-ene cyclopentene derivative able to cyclise to form the steroid ring C (pee) with a trans conformation and a 13-β methyl substituent.. Further binding of propyne on the metal site together with the N-indenyl bound adduct enables the B-ring (eep) to form with a trans orientation and a 10-β-methyl substituent. Further addition of two ethyne monomers to the Mg.porphin.N-phenanthrenyl bound adduct allows cyclisation to form the A-ring (pee). The polymerization is curtailed by reaction with hydroxyl radical to form the 3-keto substituent. The cleavage of the Mg.porphin catalyst produces the double bond of pregnane-4,5-diene-3,20-dione. The reactions have been shown to be feasible from the overall enthalpy changes in the ZKE approximation at the HF and MP2 /6-31G* level, and with acceptable activation energies.
Point to Point: A Critique to “Using Rasch Analysis to Create and Evaluate a Measurement Instrument for Foreign Language Classroom Speaking Anxiety”
Authors: Panayides Panayiotis
Published: February 2020

Apple (2013) published a study in a commendable attempt at bringing to light the many advantages of the Rasch models over Classical Test Theory (CTT) and other Item Response Theory (IRT) models and how they can be productively used in contexts where researchers are measuring foreign language anxiety (FLA). Of special importance, and much to Apple’s credit, is the detailed procedure followed for the establishment of the unidimensionality of the Foreign Language Classroom Speaking Anxiety Scale (FLCSAS).
PENERIMAAN RETRIBUSI PASAR KABUPATEN LEBONG (Studi Terhadap Jumlah Pedagang Dan Pertumbuhan Ekonomi )
Authors: REVOLINA ELLYA , - Yuliani
Published: February 2020

Ellya Revolina, Yuliani; The purpose of this research is todetermine the influence ofthe number of tradersstalls, stalls andgrowingmerchantekonomiterhadapdistrictleviesLebongtahunmarketin2004- 2011is thedatathat I usesecondary dataandsamplingmethodsdoneby purposive sampling methodie the number ofmerchantstalls, stalls andgrowingmerchantekonomiterhadapDistrictleviesLebongtahunmarketin2004- 2011Based onthe calculationresultsobtainedcoefficientof Multiple Determination(R2) for0,972berartithata variablenumber oftradersstalls(X1), the number of traderslos(X¬2) andeconomicgrowth(X3) contributedin influencingmarketlevies(Y) of 97.20% while the remaining2.80% areother variables notexamined in this study. Calculated F value of53,663while the Ftabledengan=0.05is equal to6.590asthe value ofF calculated> Ftable(53,663> 6.590) thenHo is rejected,meaning thatthere is no influenceofthe number of tradersstalls(X1), the number of traderslos(X¬2 )danpertumbuhaneconomy(X3) jointlyagainstleviesmarket(Y) tthe valuefora variablenumber oftradersstalls(X1) is5.015; t valuefora variablenumber oftraderslos(X2) is equal10,357dant valueforthe economicgrowthvariable(X3) is equal to2.3064,130sedangkant tableisbecausethe value oft count>t table(5.015> 2.306; 10.357> 2.306and4.130>2.306) means thatthe variablenumber oftradersstalls(X¬1); number oftraderslos(X2) andeconomicgrowth(X3) partial/individualhas an influence onthe marketlevies(Y). Key words:merchantstalls, traderslos, economicgrowth, marketlevies
ANALISIS LAPORAN KEUANGAN UNTUK MENILAI PRESTASI PERUSAHAAN MANUFAKTUR SUB SEKTOR SEMEN YANG TERDAFTAR DI BURSA EFEK INDONESIA
Authors: Yansi Melvi
Published: February 2020

Melvi Yansi: This study aims to better know the performance of cement companies were assessed from the financial statements, by taking samples of the two cement companies listed on stock exchanges of Indonesia, namely PT. Indocement Tunggal Perkasa Tbk and PT. Holcim, Tbk from 2014 until 2015. This research is comparative, according to four financial ratios may indicate that the financial performance. Indocement Tunggal Perkasa, Tbk is good enough only for the activity ratio and ROE, and ROI are still not good, while financial performance. Holcim, respectively Tbk unfavorable. PT. Indocement Tunggal Perkasa, Tbk expected to be able to sustain the financial performance of existing and further enhanced in the utilization of current assets, whereas for PT. Holcim, Tbk to be able to improve the financial performance of existing again with lebik better cash management company that will be used to pay liabilities of the company.Key Words: Financial Statements, Financial Ratios.
PERILAKU KONSUMEN TERHADAP PEMAKAIAN JAMU CAP NYONYA MENEER DI KOTAMADYA BENGKULU
Authors: Wijaya Ermy
Published: February 2020

Ermy Wijaya ; The aim of this study is to determine is there any significant relationship between the outside behavior variables of consumers to the consumption rate of Jamu Cap Nyonya Meneer and is there influence of inside behavior variables of consumer to the consumption rate of Jamu Cap Nyonya Meneer. Gading Cempaka Subdistrict Bengkulu City is a research area that is selected with the population of research is the households that live in Bengkulu City. The sample was carried out based on specific criteria, i.e all households classified as mature or aged 15 years and above. From the population were classified into five villages, each village elected were taken as sample. The result gained from the study was as follows: age level as a variable behavior has influence on consumers’ behavior to the consumption rate of Jamu Cap Nyonya Meneerin accordance with the age level. Where, at the age of 15-19 tends to consume Jamu Cap Nyonya Meneerat least once, at the age of 20 - 50 and above tends to consume Jamu Cap Nyonya Meneerincreases. From the test results showed a statistically significant relationship between the levels of education as outside behavior variable to the consumers’ behavior of Jamu Cap Nyonya Meneer. The level income ofoutside behavior variables has significant relationships on consumers’ behavior of Jamu Cap Nyonya Meneer.Key Words : Consumers’ Behavior, Level Of Consumstion.