bluuebunny/crossref_metadata_2025 huggingface dataset:
Stereo Educational Game with Vision Based Interaction in Virtual Environment
Authors: He Hanwu , Duan Xianyin , Wu Yueming
Published: October 2019

Interaction and immersion are crucial to educational game quality. Thus, a vision based marker location interaction and stereo rendering method for the game are proposed. This approach could support the players to have more intuitive interaction and more immersion feeling. First, a general architecture of the educational game based on computer vision marker localization interaction was presented. Then, a new method to vision based marker localization and identification interaction was studied. The basic idea of this interaction is using a static camera to track the position and pose information of the marker in the handheld device. So the game system can judge the operation purposes of players such as pick up or put down a virtual objects based on the position and pose information of the marker easily. The experiment result shows this interactive method has a high tracking accuracy. Furthermore, rendering module of the game is designed by using a stereo rendering method, so it can produce stereo vision for players. Last, a feeding animal game for children is realized to verify the presented approaches. Children can carry different food to different animals by a handheld device with marker so that they can learn what food the animals like. The running result illustrates that the presented approaches are effective, and they can provide a natural interaction for game in virtual environment
Automatic Modeling of Frequent Behaviors of Avatars and Players in a On Line Game
Authors: Chiu Chih-Ming , Hung Shao-Shin , Tsay Jyh-Jong
Published: October 2019

Millions of people now participate in on line games, placing tremendous and often unpredictable maintenance burdens on their operators. Thus, understanding the dynamic behaviors of a player is critical for the systems, network, and designers. To the best of our knowledge, little work builds character interaction model based on the data stream mining. This work improves our understanding the behaviors of avatar/player in a on line game by collecting the behavior data, extracting frequent behavior patterns, learning the hidden hints and making good prediction on responses to the unexpected impacts. Besides, we develop two efficient approaches for mining the behavior data to find the interesting behavior pattern for future prediction on responses of opponents. Our novel findings include the following: One, due to the constraints of limited resources of time, memory, and sample size, MSS-MB was proposed to meet these conditions; the other, due to the constraints of real-time and on-line, there may have some errors occurred in the processing period, MSS-BE was proposed to control the errors as needed. Finally, based on the experimental results, we can predict the responses of opponents efficiently in the on line game.
A Fast and Practical Method for Animating Particle-Based Viscoelastic Fluids
Authors: Takamatsu Kenji , Kanai Takashi
Published: October 2019

This paper proposes a practical technique for fast animation of materials such as viscoelastic fluids. A fast animation of such materials is desperately desirable especially for real-time applications such as games. We compute the behavior of viscoelastic fluids approximately instead of the exact simulation by combining two well-established approaches, Smoothed- Particle Hydrodynamics and Shape Matching. This enables fast and stable computations. A combination is done by a simple linear interpolation of velocities. A variety of materials between a fluid and an elastic solid can be represented by changing only a parameter of linear interpolation. We also propose how to bring our approximate method closer to the actual motions of viscoelastic fluids including merging or splitting of objects. We demonstrate a high-speed performance of our method with presenting several interesting results.
Effective T-spline representation for VRML
Authors: Chen Wenyu , Li Yusha , Pan Jianjiang , Zheng Jianmin , Cai Yiyu
Published: October 2019

Less control points are needed to represent a shape in T-Splines compared to NURBS and subsequently less time is spent in modeling. While getting more and more accepted by commercial software, T-splines, however, are yet part of VRML/X3D. The T-spline VRML is proposed in this work. An effective data structure is designed for T-splines to support online visualization. Compared to the NURBS and the polygonal representations, the proposed T-spline data structure representation can significantly reduce the VRML file size which is a central concern in online applications. As such, complex objects modeled in T-spline form have better chances for real-time transfer from servers to clients. Similar to other VRML nodes, T-spline VRML node can support geometry, color and texture. Users can interact with T-spline more effectively for LOD and animation applications.
ARTiFICe - Augmented Reality Framework for Distributed Collaboration
Authors: Mossel Annette , Schönauer Christian , Gerstweiler Georg , Kaufmann Hannes
Published: October 2019

This paper introduces a flexible and powerful software framework based on an off the shelf game engine which is used to develop distributed and collaborative virtual and augmented reality applications. We describe ARTiFICe's flexible design and implementation and demonstrate its use in research and teaching where 97 students in two lab courses developed AR applications with it. Applications are presented on mobile, desktop and immersive systems using low cost 6-DOF input devices (Microsoft Kinect, Razer Hydra, SpaceNavigator), that we integrated into our framework.
Virtual Table-Teleporter: Image Processing and Rendering for Horizontal Stereoscopic Display
Authors: Madeira Bruno Eduardo , Velho Luiz
Published: October 2019

We describe a new architecture composed of software and hardware for displaying stereoscopic images over a horizontal surface. It works as a ``Virtual Table and Teleporter'', in the sense that virtual objects depicted over a table have the appearance of real objects. This system can be used for visualization and interaction. We propose two basic configurations: the Virtual Table, consisting of a single display surface, and the Virtual Teleporter, consisting of a pair of tables for image capture and display. The Virtual Table displays either 3D computer generated images or previously captured stereoscopic video and can be used for interactive applications. The Virtual Teleporter captures and transmits stereoscopic video from one table to the other and can be used for telepresence applications. In both configurations the images are properly deformed and displayed for horizontal 3D stereo. In the Virtual Teleporter two cameras are pointed to the first table, capturing a stereoscopic image pair. These images are shown on the second table that is, in fact, a stereoscopic display positioned horizontally. Many applications can benefit from this technology such as virtual reality, games, teleconferencing, and distance learning. We present some interactive applications that we developed using this architecture.
Glassless Augmented Display for Public Signage
Authors: SUZUKI Hisataka , Shirai Akihiko , Yanaka Kazuhisa
Published: October 2019

This project realizes spatial augmented reality in public. We developed Glassless Augmented Display( GAD) which can show multiple different images to different direction simultaneously. Spatial augmented reality allows audiences to watch their preferred images and audios on public signage. It is a highly applicable technology configured by a consumer-based 4K liquid crystal display, superdirective speakers, a lenticular lens, and a multi-view image synthesizer implemented in a Unity application. We also proposed an application for GAD, which is called Simultaneous Spatial Shared Display (SSSD), which is implemented on Glassless Augmented Diaplay. SSSD enabled (1) simulmultiplex content display, (2) perspective correction, (3) without glasses and any sensing system, (4) directional audio for each content, and (5) attachable to conventional 2D display. These are used to display various contents, such as sports games and concerts, according to the movement of the audience.
Empty Room, how to compose and spatialize electroacoustic music in VR in ambisonic and binaural
Authors: Webster Christine , Garnier François , Sedes Anne
Published: October 2019

Presentation of the Empty Room project, dedicated to the exploration of new musical composition and spatialization methods in virtual 3D spaces developped on multiplayer or mono player technologies such as Second Life, Open Simulator and Unity 3D, using the latest video game and virtual reality technologies.
"Real Baby - Real Family" Multi-Sensory Feedback Tangible Baby VR
Authors: Hsieh Rex , Mochizuki Yuya , Asano Takaya , Higashida Marika , Shirai Akihiko
Published: October 2019

"Real Baby - Real Family" is a Virtual Reality baby nursery simulator that aims at conveying the parental and family love to the audiences. It has since been exhibited at Laval Virtual 2017, Anime Expo 2017, and SIGGRAPH 2017. This article will attempt to discuss the feedback and reviews gathered during the international exhibitions and shed light on the future development of this project.
Exploring Enjoyment of Cinematic Narratives in Virtual Reality: A Comparison Study
Authors: Shafer Daniel M. , Carbonara Corey P. , Korpi Michael F.
Published: October 2019

This study compares watching a film in a traditional theater setting to watching the same film in a virtual theater using a virtual reality (VR) head-mounted display (HMD). The study seeks to determine whether watching a film in a virtual theater is a comfortable experience that viewers can tolerate; and whether watching in VR produces similar feelings of identification, transportation, and enjoyment for the films as watching in a traditional theater. Using the Oculus Rift DK2 HMD and the Riftmax virtual theater software, participants watched either Signs or Ferris Bueller's Day Off in a virtual theater. Other participants watched the same films in a traditional theater setting, and independent comparisons were made. Results indicate that over 90% of the VR participants were able to watch the entire movie in the virtual theater, and feelings of identification, transportation, and enjoyment were quite similar between conditions. Differences found were attributable to the films' content, with an interaction between VR and theater conditions. Implications and future research are discussed.
On Dual Hyperbolic Generalized Fibonacci Numbers
Authors: Soykan Yüksel
Published: October 2019

In this paper, we introduce the generalized dual hyperbolic Fibonacci numbers. As special cases, we deal with dual hyperbolic Fibonacci and dual hyperbolic Lucas numbers. We present Binet's formulas, generating functions and the summation formulas for these numbers. Moreover, we give Catalan's, Cassini's, d'Ocagne's, Gelin-Cesàro's, Melham's identities and present matrices related with these sequences.
Geochemical Anomaly Separation by Statistical and Fractal Methods in the Sehezar Valley of Tonekabon – Northern Iran
Authors: Yazdani Meysam , Alinia Firouz
Published: October 2019

Sehezar area is located in southern Tonokabon in Mazandaran province, north of Iran, near the Tarom – Hashdtjin belt. The existence of granitoid masses in the region can be important in terms of the potential of mineralization. Geochemical anomaly separation from the background is one of the important steps in mineral exploration. In the past decades, geochemical anomalies have been identified by means of various methods. Some of these separation methods include: statistical analysis methods (like univariate, bivariate, multivariate statistics), spatial statistical methods and fractal and multi-fractal methods. To identify the anomalous area, 71 stream sediment samples were collected from the area and analyzed by the ICP-MS method, and then interpreted. Initially, data were normalized and afterwards, univariate analysis (threshold limit and screening (P.N) methods) was used, in which results of the probable and definite anomaly of the threshold method were confirmed by the P.N screening method. Finally, the maps of the anomal zones were drawn. Then, bivariate analysis (Pearson correlation coefficients) and multivariate analysis on normal data were performed on SPSS software, in which factor analysis and cluster analysis were used for multivariate analysis. As a result of using the factor analysis method, six factors were identified and factor maps were drawn by the Surfer software. Also, by using cluster analysis, the variables were divided into two groups. In order for a better separation of the geochemical anomaly from the background, in addition to the threshold method, the Concentration - Area fractal method was used. Here, the fractal geometry using full-logarithmic graphs of the Concentration - Area obtained is capable of separating the stairs of different sections (background, threshold, and anomaly) with respect to the angle coefficient of the Concentration - Area plot. Then, in conclusion, results of these methods were compared and investigated, and finally, the anomalies area maps of the Au, Ag, Cu, Fe, W elements were drawn by Concentration - Area fractal and threshold methods and anomalous zones were introduced.
DINING ON RECIPROCITY IN LOCAL FOOD SYSTEMS: TOWARDS A MORAL ECONOMY OF FOODS
Authors: Zhao Li
Published: October 2019

China has witnessed a growing number of social and environmental challenges, which remain obstacles for its rural vitalization. At the core of the discussion on sustainable agriculture and rural development lies the development of sustainable food systems. This article conducts a case study and examines a local food network which has created a reciprocity mechanism between smallholder producers and consumers. The discussion puts a particular emphasis on the interaction between sustainable consumption and production initiatives in the process of achieving the network’s ecological goals. Based on the discussion and findings, the study concludes by proposing to draw on the concept of the moral economy and constructing “a moral economy of foods” to conceptualize social structure of local food systems. In a re- localization process of “local cultural repertoires of foods”, while protocols of certification and traceability could constitute conclusive proofs of the moral economy of foods, a belief in sustainable food systems would stand the moral economy itself in good stead in a time when trust and confidence in the foods labeled “organic” are diminished. The findings presented in the study may have significant implications for designing policies for rural vitalization in China and promoting transitions to more sustainable agriculture and rural livelihoods.
Age is a predictor for the recurrence of syncope in vasovagal syncope patients with a positive head-up tilt test
Authors: Guo Yongjuan , Chen Xiaomin , Zeng Tianze , Wang Lin , Cen Lvwei
Published: October 2019

BACKROUND Valid predictors of the recurrence of syncope in vasovagal syncope (VVS) patients with a positive head-up tilt test (HUTT) are currently lacking. The goal of this study was to identify the predictive performance of age for the recurrence of syncope in VVS patients with a positive HUTT.
METHODS in total, 175 VVS patients with a positive HUTT were followed for 6 to 32 months, and ≥1 syncope episodes during follow-up was considered the recurrence of syncope. The study population was divided into 2 groups, namely, a recurrence of syncope group (44 patients) and a no recurrence of syncope group (131 patients). The baseline clinical data, hemodynamic parameters and classification of the vasovagal syncope on the HUTT were analyzed. Binary logistics regression was used to analyze the effect size and confidence interval of age. A receiver operating characteristic(ROC) analysis was used to assess the predictive performance and investigate the predictive value of age by the area under the curve (AUC).
RESULTS The age of recurrence of syncope group 60.0 (47.8, 66.0) years was older than that of no recurrence of syncope group 53.0 (43.0, 62.0) years, and there was a significant difference between the two groups (P < 0.05). The trend of syncope recurrence changed with age and the binary logistics regression model adjusted by sex showed that the elder was an increased risk of syncope recurrence in VVS with positive HUTT [OR value: 1.034, 95% confidence interval(CI) 1.008 to 1.061 p < 0.05].Age was a valid predictor for the recurrence of syncope in VVS patients with a positive HUTT (AUC: 0.688; 95%CI 0.598 to 0.777 p < 0.05) . The cut-off value was 53.5 years, and the sensitivity and specificity were 72.7% and 52.7%, respectively.
CONCLUSIONS Age was a valid predictor for recurrence of syncope in VVS patients with positive HUTT. The rate of recurrence of syncope increased with increasing age, especially in old female.
The role of sociocultural contexts in forming adult HIV-patients’ behavior towards the prevention of metabolic syndrome: A descriptive phenomenological study
Authors: Bune Girma Tenkolu , Yalew Alemayehu Worku , Kumie Abera
Published: October 2019

Background: The human immunodeficiency virus-associated metabolic syndrome (MS) in Sub-Saharan Africa (SSA) is becoming an important concern for its additional disease burdens imposed on society, intensified with limited knowledge of how to prevent and recognize the sociocultural contexts' role in dictating behavior towards the modifiable risks. The aim of the study identify the role of sociocultural contexts in shaping individual PLWHs behavior focused on how knowledge, attitudes, and practices (KAP) influence the feeding habits, physical activity and harmful substance use habits among adult PLWHs, in the Gedeo zone, South Ethiopia. Methods: A deductive descriptive phenomenological study, complemented with a thematic content analysis approaches, enhanced with the focus group discussion (FGDs) and an in-depth interview method were employed; starting from February 1st to 30th of March 2018. Adult PLWHs and their corresponding care providers were purposefully chosen and involved in the interview. Finally, Atlas. ti (V.7.5.7) and SPSS (V.20) software were used to handle and analyze all text and survey data respectively iteratively; finally result is reported using the consolidated criteria for reporting qualitative research (COREQ) checklist. Result: A total of six (n=4 FGDs and n=2 in-depth) interviews, arranged in a total number (N=32) male and female PLWHS, whose mean age of 36.96 (+ 8.94) years and duration of treatment 5.19 (SD 3.16) years were involved. The coded response dictated the knowledge and practices regarding the dietary habits, intentional physical activities and other lifestyle behavior into the inadequate group; as well as the attitude into an unfavorable direction. Conclusion: The absence of adequate knowledge about MS and its risk prevention mechanisms leads to the unfavorable attitude and inadequate practices. This implicates the significance of the adoption of the healthy living practices associated awareness creation program targeted the PLWHs to impact their behavior to enable better control of NCDs and its consequences.
The status of college students' sleep quality and its relationship with internet addiction, anxiety and depression
Authors: Jiang Minmin , Zhao Ying , Wang Yanqiu , Wang Jing , Ai Dong , Yao Yingshui , Jin Yuelong
Published: October 2019

Background:The problem of the decline of college students' sleep quality has gradually become a major factor affecting the physical and mental health of college students. The present study mainly explored the status of college students' sleep quality and its relationship with internet addiction, anxiety and depression.Methods:A sample of 5794 college students(18.89±1.10) from two randomly selected college from Anhui in China completed the measurement of sleep quality,Internet addiction,anxiety and depression.Sleep quality was measured by the Pittsburgh Sleep Quality Index (PSQI).Results:The total detection rate of sleep disorder was 31.30% and the average score of PSQI was 6.27±2.62 in 5974 college students. Sleep disorders rate of females(c 2 =76.503, P <0.001) and PSQI average scores (t=-11.915, P <0.001) were significantly higher than those of males. Students in non-medical colleges had higher sleep disorders rate (c 2 =6.880, P <0.001) and PSQI average scores (t=-3.668, P <0.001) than medical college students.The sleep quality of college students was positively correlated with internet addiction (r=0.197, P <0.05), anxiety (r=0.227, P <0.05) and depression (r=0.268, P <0.05). The probability of females having sleep disorders was 1.726 times than that of males( OR =1.726, P <0.001).Third grade students were more prone to have sleep disorders( OR =1.240, P <0.05).Internet addiction ( OR =1.336, P <0.001), anxiety ( OR =1.695, P <0.001) and depression ( OR =1.964, P <0.001) were risk factors of sleep quality. Extroverted personality was a protective factor ( OR =-0.689, P <0.001).Conclusion:These findings suggested that college students had a high rate of sleep disorders. Schools and related departments should take appropriate measures to improve the sleep quality and promote physical and mental health of college student. Keywords :Sleep quality,College student,Internet addiction, Anxiety, Depression
Factors influencing whether or not male partners from low and middle income countries attend childbirth: a mixed methods systematic review
Authors: UHAWENIMANA Thierry
Published: October 2019

Currently, there is a global drive to promote respectful maternity care including a woman’s right to have a companion of her choice during labour and birth. This may include but is not limited to doula, female relatives or friends, and male partners. Evidence suggests that male partners’ attendance at childbirth, when it is a woman’s choice, may be associated with a positive emotional experience for the woman. However, these potential benefits were reported from studies conducted in high income settings only. There is limited information about male partners’ attendance at labour and birth in low and middle income countries (LMICs). Although male partners’ attendance at childbirth is being implemented in a few health facilities in LMICs, there is a paucity of evidence on the acceptability and feasibility of this practice and the moderators of implementation in the context of LMICs.
The diagnostic performance of TB-IGRA on HIV infected patients with active tuberculosis is associated with CD4+ T-cell counts
Authors: Wang Mengyan , Chen Tongtong , Dong Xiaotian , Zhang Zhongdong , Shi Jinchuan , Yan Jun , Yu Jianhua
Published: October 2019

Objective: To investigate the factors associated with the diagnostic performance of interferon-gamma release assay (IGRA) in HIV infected patients with active tuberculosis (TB). Methods: We retrospectively analyzed the data of HIV infected patients with active tuberculosis patients from 2016-2019 who conformed with the inclusion criteria and the exclusion criteria. All patients included were performed with TB-IGRA. For evaluating the diagnostic performance of TB-IGRA, patients were divided into positive TB-IGRA and negative TB-IGRA groups. And all statistical analysis was performed using SPSS Results: Performed by logistic regression analysis, we found that CD4 cell counts is independent risk factor for false negative of TB-IGRA(P<0.001). Additionally, false negative of TB-IGRA were 68.75%, 24.29% and 14.63%, respectively, in the three groups whose CD4+ T cell counts were <20/μL, 20-100/μL and >100/μL, with the highest frequency in subjects with CD4+ T cell counts <20/μL(P<0.001). And false negative of TB-IGRA were 68.75%, 27.77%, 20.58% and 14.63%, respectively, in the four groups <20/μL (n = 32), 20-50/μL (n = 36) ,51-100/μL (n = 34) and >100/μL (n = 82). The group of CD4+ T cell counts <20/μL had the highest false negative (P<0.001). There was no significant difference in the groups of 20-50/μL, 51-100/μL and >100/μL (P=0.483, P=0.623, respectively). Conclusion: The low level of CD4+ T-cell counts increase false negative TB-IGRA in HIV infected patients with active tuberculosis. These data suggest IGRA assays may have unreliable diagnostic performance results among patients with advanced HIV especially CD4+ T cell counts were <20/μL.
Regulamento do Ensino Primário e Normal do Estado do Rio Grande do Norte
Authors: Araujo Marta Maria
Published: October 2019

No governo de Dinarte de Medeiros Mariz e José Augusto Varela (1956-1961) foi empreendida uma reforma educacional ordenada pela Lei n° 2.171, de 6 de dezembro de 1957, preconizando organizar e fixar as bases da Educação Primária e da Formação do Magistério no Estado do Rio Grande do Norte. Passados três anos da aprovação dessa reforma educacional de 1957, o governador Dinarte de Medeiros Mariz sancionou (Decreto n° 3.590, de 1° de fevereiro de 1960), o Regulamento do Ensino Primário e Normal do Estado do Rio Grande do Norte cujo Título I é o da Obrigação Escolar que reafirmava a obrigatoriedade do ensino primário para todas as crianças de 7 a 13 anos, e o dever do Estado em assegurar os meios e as condições para o cumprimento dessa obrigação. Para o cumprimento da obrigatoriedade escolar, o Estado ampliaria a rede escolar e o número de professores primários, em preparação com as necessidades devidamente recenseadas. Em face da relevância desse Regulamento de 1960 para História da Educação do Rio Grande do Norte é que se publica nesta Seção de Documento.
Campanha de Pé no Chão Também se Aprende a Ler. Entrevista com Moacyr de Góes
Authors: Araujo Marta Maria
Published: October 2019

Neste ano de 2015, no Rio Grande do Norte, instituições de direitos humanos, culturais e educacionais organizaram homenagens, seminários e audiências públicas pelos cem anos de nascimento de Djalma Maranhão (1915-2015) e divulgaram um cartaz comemorativo – Três Dimensões de Djalma Maranhão: Política, Educação e Cultura. Especialmente no governo municipal de Djalma Maranhão (1960-1964), o Secretário de Educação de Natal, Moacyr de Góes, professor, educador e intelectual comprometido com os problemas humanos e sociais do seu tempo, planejou, coordenou e dinamizou a Campanha de Pé no Chão Também se Aprende a Ler, reconhecida como um Movimento de Educação Popular e de construção de uma Escola democrática. Por tudo que representou esse Movimento de Educação Popular e a Experiência da Campanha de Pé no Chão Também se Aprende a Ler para a construção das bases teóricas de uma Escola democrática, o Conselho Editorial da Revista Educação em Questão decidiu republicar a entrevista de Moacyr de Góes nesta edição da Revista Educação em Questão.
Identidade profissional de professoras que ensinam matemática nos anos iniciais
Authors: Bolognani Marjorie Samira Ferreira , Nacarato Adair Mendes
Published: October 2019

Este texto discute as relações entre trabalho docente, formação, saberes e construção da identidade profissional. A pesquisa foi realizada com dez professoras que atuam nos anos iniciais do ensino fundamental e teve, como foco, o ensino de matemática. Os dados foram produzidos por entrevistas narrativas e grupo de discussão. Aquilo que as professoras lembram e narram trazem indícios de como os processos de formação vivenciados e o trabalho desenvolvido são por elas interpretados e ressignificados. Tais narrações, com a tomada de consciência, parecem ser determinantes à formação contínua delas, sinalizando o quanto as narrativas se constituem em práticas de autoformação.
Cinema em sala de aula:
Authors: Perinelli Neto Humberto , Paziani Rodrigo Ribeiro
Published: October 2019

Atualmente, várias são as reflexões sobre o diálogo entre Tecnologias da Informação e Comunicação e Educação. Este artigo, visa, pois, apresentar pesquisa, procurando traçar entendimento sobre o emprego de cinema em salas de aulas do Ensino Fundamental I. Por meio de método “qualiquantitativo”, traçam-se os limites e as possibilidades vinculadas à utilização escolar desse tipo de linguagem. Busca-se, assim, colaborar com a apropriação do cinema nos processos formativos educacionais baseados na autonomia pedagógica, na construção do aprendizado crítico e lúdico e na validade de propostas de ensino, caracterizadas pela inter e transdisciplinaridade.
What Can We Learn from Sarcopenia with Curarisation in the Context of Cancer Surgery? A Review of the Literature
Authors: Samouri Georges , Stouffs Alexandre , Essen Lionel V. , Simonet Olivier , De Kock Marc , Forget Patrice
Published: October 2019

Introduction:

The monitoring of the curarisation is a unique opportunity to investigate the function of
the neuromuscular junction (NMJ) during cancer surgery, especially in frailty-induced and age-related sarcopenia.

Method:

We conducted a comprehensive literature review in PubMed, without any limit of time related to frailty,
sarcopenia, age and response to neuromuscular blockers in the context of cancer surgery.

Results:

Several modifications appear with age: changes in cardiac output, a decrease in muscle mass and increase
in body fat, the deterioration in renal and hepatic function, the plasma clearance and the volume of distribution
in elderly are smaller. These changes can be exacerbated in cancer patients. We also find modifications of
the NMJ: dysfunctional mitochondria, modifications in the innervation of muscle fibers and motor units, uncoupling
of the excitation-contraction of muscle fibers, inflammation.

:

Neuromuscular blocking agents (NMBAs) compete with acetylcholine and prevent it from fixing itself on its
receptor. Many publications reported guidelines for using NMBAs in the elderly, based on studies comparing old
people with young people.

:

No one screened frailty before, and thus, no studies compared frail elderly and non-frail elderly undergoing cancer
surgery.

Conclusion:

Despite many studies about curarisation in the specific populations, and many arguments for a potential
interest for investigation, no studies investigated specifically the response to NMBAs in regard of the
frailty-induced and age-related sarcopenia.
Floating Drug Delivery Systems: An Emerging Trend for the Treatment of Peptic Ulcer
Authors: Namdev Ankit , Jain Dharmendra
Published: October 2019

:

Floating drug delivery system (FDDS) is the main approach to prolonging the gastric residence
time in the stomach in which the bilayer floating tablet has the main role. It is more suitable for
the treatment of local infections such as peptic ulcer, gastritis, Zollinger-Ellision syndrome, indigestion,
and other local infections related to the gastrointestinal tract and also used for systemic applications.
FDDS provides protection for those drugs which are acid labile and have a short half-life. It also improves
bioavailability, reduces drug waste, and enhances the residence time of drugs. Nowadays, various
technologies are being used for the development of FDDS. Novel drug delivery systems incorporation
into bilayer floating tablets have also broadened the role of FDDS. Polymers have the main role in
the development of FDDS, which serve as carriers for the drug and determine the gastric retention time
and drug protection. FDDS is also an easy, cheap, and more convenient method for dual drug delivery
of drugs.
Recent Advances in Drug Delivery Strategies for Improved Therapeutic Efficacy of Efavirenz
Authors: Patel Mitali , Shah Ruhi , Sawant Krutika
Published: October 2019

Background:

Efavirenz, an anti-HIV agent, has a noticeable place in the HAART regimen
for the treatment and maintenance therapy of AIDS. However, its poor water solubility accounts for
hindered absorption and bio-distribution upon administration. This results in its low and variable bioavailability.
To circumvent these limitations, various novel formulations of Efavirenz have been investigated
in order to mitigate its drawbacks and draw out its maximum therapeutic effect.

Methods:

Numerous formulations explored to overcome the drawbacks of Efavirenz include modified/
controlled-release tablets, solid dispersions, polymeric nanoparticles, dendrimers, surface-engineered
nanoparticles and various other nanoformulations. Moreover, combinatorial formulations of Efavirenz
with other Anti-HIV drugs have also been reported to overcome the problem of Drug-Resistance.

Results:

The nanoformulation based strategies, owing to their ability to provide controlled release profile
and targeted drug delivery were found to augment bioavailability, therapeutic efficacy and reduce
the side effects of the Efavirenz.

Conclusion:

This review pivots around the challenges and recent advances in the delivery of Efavirenz
with particular emphasis on novel formulations including its patents.
Livestock Poisoning Plants: Identification and its Veterinary Importance in Afar Region of Ethiopia
Authors: Desta Angesom H.
Published: October 2019

Background:

Plants are the major source of feed and have vital nutritious importance to animals; however, they also comprise a large variety of poisons known.

Objective:

A study was conducted to identify potential poisonous plants to domestic animals and its veterinary importance in selected districts of Afar region, Northeast Ethiopia.

Methodology:

Questionnaire survey and key informants interview were done with a total of 245 respondents and plant samples were taken for identification.

Results:

A total of 21 plants were identified and documented to have a poisonous effect on livestock. The poisonous plants frequently complained by the respondents wereCapparis tomentosa, Prosopis juliflora, Parthenium hysterophorus, Lantana camara, Acacia absynica, Sorghum bicolar, Datura stramonium, Plantago lanceolata,Pteridium aquilinumandSolanum incanum. The majorly described predisposing factors for the occurrence of plant poisoning were feed shortage, nutritional deficiency and excessive consumption. The common poisoning seasons indicated were at the end of rainy season and during drought time. The plant parts that caused poisoning were leaves of plants. This study also revealed that bloating and other GIT disturbances, salivation, bloody urine and in appetance were among the frequently manifested signs in poisoned livestock. Moreover, this study showed that caprine and ovine followed by camels and bovine were the most frequently poisoned animals.

Conclusion:

Phytopoisoning is commonly occurring and challenging health of livestock in the study area. Hence, proper range management should be practiced to decrease the danger of plant poisoning to animals and all concerned bodies should collaborate on pasture and water development programs to minimize the risk of enforced consumption of livestock on poisonous plants due to feed shortage.
Luxe shuttles worden structureel onderdeel van het woon-werkverkeer
Authors: Groot Linda
Published: October 2019

Als het openbaar vervoer een groter deelvan het forensenverkeer naar zich toe wiltrekken, dan zal het sneller, comfortabeleren accurater moeten worden. Ook deNederlandse streekvervoerders zijn zichdaarvan bewust. Vandaar dat de afgelopenpaar jaar op diverse plaatsen in hetland projecten zijn gestart met specialespitsbussen die een hogere kwaliteit biedendan l}et reguliere openbaar vervoer.
Feasibility of the Internet Attachment–Based Compassion Therapy in the General Population: Protocol for an Open-Label Uncontrolled Pilot Trial (Preprint)
Authors: Campos Daniel , Navarro-Gil Mayte , Herrera-Mercadal Paola , Martínez-García Laura , Cebolla Ausiàs , Borao Luis , López-Del-Hoyo Yolanda , Castilla Diana , del Río Eva , García-Campayo Javier , Quero Soledad
Published: October 2019

BACKGROUND

Compassion-based interventions delivered over the internet are showing promising results for the promotion of psychological health and well-being. Several studies have highlighted their feasibility, acceptance, and preliminary efficacy. However, this is an incipient field of research, and to the best of our knowledge, there are no data available from Spanish-speaking countries.

OBJECTIVE

The aim of this study is to investigate the feasibility, acceptance, and preliminary efficacy of the Internet Attachment–Based Compassion Therapy (iABCT), a web-based version of the Attachment-Based Compassion Therapy, in Spanish speakers from the general population.

METHODS

This feasibility study features a single-arm, uncontrolled, within-group design with an embedded qualitative and quantitative process evaluation at baseline, immediately after the intervention and at the 3-month follow-up. A minimum of 35 participants from the general population will be allocated to iABCT. Feasibility measures will include attrition rate, patterns of use of the web-based system, and participants’ acceptability, usability, and opinion. The primary outcome was measured using the Pemberton Happiness Index. Secondary outcomes were measured using the Compassion Scale, Self-Compassion Scale, Forms of Self-Criticizing/Attacking and Self-Reassuring Scale-Short form, Five Facets of Mindfulness Questionnaire, Relationships Questionnaire, General Health Questionnaire, Non-Attachment Scale, International Positive and Negative Affect Schedule Short Form, Purpose-In-Life Test, and difficulties regarding the practice of compassion (Compassion Practice Quality Questionnaire). Mixed models will be used to evaluate primary and secondary outcome measures. A qualitative content analysis of the participants’ qualitative responses will also be performed.

RESULTS

Enrollment started in February 2020 and will be finished in April 2020. Data analysis will start in October 2020.

CONCLUSIONS

To our knowledge, this study will, for the first time, show data on the feasibility, acceptability, and preliminary efficacy of web-based compassion (and self-compassion) training—that is, the adapted iABCT—in Spanish speakers from the general population. Further aspects of their implementation (ie, facilitators, barriers, and unwanted effects) and mechanisms of change will be investigated. This study will allow the revision and fine-tuning of the developed intervention, study design, and planning procedures, as well as the initiation of a future randomized controlled trial.

CLINICALTRIAL

Clinicaltrials.gov: NCT03918746. Registered on April 17, 2019. Protocol version 1, 6 March 2019.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/16717
Persistencia del síndrome burnout en internos de medicina en hospitales de Lima, Perú (año 2018)
Authors: Chacaltana Linaresa Karen Cecilia , Rojas Camab Luis Felipe
Published: October 2019

Introducción: El síndrome de burnout es un trastorno patológico que afecta de forma persistente a internos de medicina de hospitales de Lima.

Objetivo: Determinar la frecuencia del síndrome burnout en internos de medicina que inician-culminan el internado y determinar sus factores relacionados.

Método: Se realizó un estudio transversal con los estudiantes de medicina del séptimo año (n = 165) entre diciembre 2017 y marzo del 2018. Se usó la escala Maslach Burnout Inventory en su versión en español.

Resultados: Se encontró una frecuencia de síndrome de burnout del 33% y 35% para internos del 2017 y 2018, respectivamente. Alrededor de la mitad de los internos presentaron un alto grado de agotamiento emocional y una alta despersonalización; siendo el síndrome burnout más frecuente en los hospitales del Ministerio de Salud (OR: 2.3, 95% IC: 1.1-4.6; p = 0.010). El internado tiende a disminuir hasta 3 veces las actividades recreativas (OR: 3.2; IC 95%: 1.7-6.2, p = 0.0022) y producir mala calidad de sueño en los internos del 2018 (OR: 5.3; 95% IC: 2.6-10.8, p < 0.05). Las rotaciones con más alta frecuencia de síndrome de burnout fueron ginecología y pediatría.

Conclusiones: Existe persistencia de síndrome de burnout en internos de medicina en comparación con estudios anteriores. Tener menos de 25 años, realizar el internado en hospitales del Ministerio de Salud, y soportar la dificultad para desplazarse a la sede hospitalaria, fueron relacionados al síndrome de burnout en internos de medicina.
Aptitud clínica final en internado de pregrado en sedes hospitalarias en Nuevo León
Authors: Cobos-Aguilar Héctor , Pérez-Cortés Patricia , Mendoza-Villalba Jaziel Israel , García-Gómez Salvador , Álvarez-Longoria Jorge Alberto , Hernández-Portales Jorge Alberto , Jacobo-Saucedo Luis Alberto , Martínez-Delgado Guillermo Hernán
Published: October 2019

Introducción: La aptitud clínica (APCL) es esencial en el médico internado de pregrado (MIP). Su evaluación es primordial. 

Objetivo: Comparar la aptitud clínica final del MIP en sedes hospitalarias. 

Método: MIP en grupos naturales que finalizaron su internado de pregrado (IP) en 5 sedes hospitalarias. Se estudiaron 70 MIP en una muestra por censo. Se aplicó un instrumento al final del IP, válido y consistente (KR: 0.77) con 30 casos clínicos (CC), con 5 indicadores: factores de riesgo (FR), diagnóstico (DX), paraclínicos (PCL), tratamiento (TRAT) y pronóstico (PRN). En medicina interna (MI), pediatría (PED), medicina familiar (MF), urgencias (URG), cirugía general (CG) y ginecobstetricia (GO). Reactivos 75 por módulo y 450 en total. Se solicitó el promedio y universidad de procedencia. Se excluyeron encuestas incompletas o mal llenadas. Estadísticos no paramétricos: para comparar las medianas de cada módulo y de cada rotación (Kruskal-Wallis). Se compararon las sedes, una contra otra (U de Mann-Whitney). Se correlacionó el promedio universitario con la mediana global (Spearman). Se determinaron las respuestas por azar. 

Resultados: No hubo correlación entre las calificaciones universitaria s y las medianas globales. Se observó una APCL baja en las sedes (Mdn: 177/450). Se encontraron diferencias significativas a favor de G1 y G5 en casi todos los módulos e indicadores vs. G4. Las medianas más altas se obtuvieron en URG (50/75) y MF (43/75) y las más bajas en GO (5/75). Los resultados fueron NS en FR y PCL. Los valores más altos se observaron en PRN (48%), seguido de DX (41%) y TX (33%). Entre universidades fueron NS en MI, CG, FR, PCL y PRN. Se obtuvieron resultados bajos en apendicitis aguda, trabajo de parto, preeclampsia y pielonefritis. 

Comentarios: Se observó una APCL aún insuficiente. Se amerita un seguimiento más estrecho de su desarrollo.
Minima Moralia y Opusculum Paedagogum
Authors: Suárez Trejo Javier
Published: October 2019

Imagination and pedagogy. The works of Theodor Adorno deal persistently with the damaged lives of human beings following the catastrophes of the twentieth century. However, for the German philosopher, no less important than that damage is the reconfiguration of the good life. Likewise, one of the leitmotifs of the works of Wallace Stevens is how imagination can give a form to the parts of a world that seemed ruined, meaningless. This essay shows that both philosopher and poet share a pedagogical approach to criticism whose dynamics is aesthetic imagination. Recognizing what is not identical to the subject and, simultaneously, the impossibility of a naked understanding of the world, not mediated by our subjectivity, Adorno and Stevens yearned to reconcile subject and object. For them, imagination becomes the tool to conceive of an “aconceptual synthesis” (Ador-no) or an “abstract imagination” (Stevens) that gives sense to the world not through totalization but through an aesthetic reconstruction.
MONTELUKAST AND LEVOCETERIZINE FIXED DOSE COMBINATION-AN EVIDENCE REVIEW
Authors: A.ANANDHASAYANAM  , BITU CHULLIKKATTIL.A  , ZACHARIAH NANISHA , SARANYA.P  , TAMILSELVAN.A
Published: October 2019

Indian pharma market is flooded with various fixed drug combinations. Among them, one of the widely used FDC is montelukast + levocetirizine. This is prescribed for the patients of any age group (paediatrics, adults and geriatric) and used as a long term therapy for the treatment of conditions such as prophylaxis, acute and chronic types of asthma, relief of symptoms of seasonal and perennial allergic rhinitis, prevention of exercise induced bronchoconstriction and chronic idiopathic urticaria. It is very essential to check the rational use of this FDC. Generally fixed dose combinations create confusions among physicians, because it contains more than one drug in various doses and it is very difficult to remember all these details and another issue with the FDCs are that the entire FDC cannot be used if the patient is contraindicated to any of the drug in the FDC. And patient specific dose calculation is also difficult with FDCs. There are very less clinical trial data available about the safety and efficacy of this agent. Objective of this review article is to check the rational use of montelukast levocetirizine FDC. To achieve the objective, all the literatures related to montelukast levocetirizine FDC were collected and analysed. The study concluded that some differences are there in the pharmacokinetic parameters of both these agents includes duration of action. In dosing also, levocetirizine dose can vary from 2.5mg to 10mg once daily whereas montelukast dosing is 10mg. Rationality of this FDC can be further supported by more clinical trial data to conform the rationality of these FDC.
A RESERVA LEGAL E AS LEGALIDADES RESERVADAS PARA A REFORMA AGRÁRIA NO ESTADO DO RIO DE JANEIRO
Authors: Lobato da Costa Rodolfo Bezerra de Menezes
Published: October 2019

Neste artigo, pretendemos apresentar dissonâncias entre os conflitos socioambientais e a reforma agrária no Estado do Rio de Janeiro. As idiossincrasias da implementação de um Projeto de Desenvolvimento Sustentável (PDS), que nasceu como uma experiência e uma conquista de setores subalternizados, torna-se, no caso estudado, uma decisão do Estado para reordenamento territorial da comunidade rural de Sebastião Lan II. Como uma proposta de cima para baixo, sem participação efetiva dos beneficiários da política de reforma agrária, reapresentamos o acúmulo de uma disputa fundiária, anteriormente formulada pela ideia de contradição entre o paradigma preservacionista e a prática da agricultura familiar. Destaca-se o objetivo de investigar a constituição da Reserva Legal como uma pista de movimentos não aparentes de concentração de terras.
Língua, discurso, cultura: reflexões discursivas sobre o processo linguístico de atribuições de nomes (próprios?)
Authors: Da Silva Esteves Phellipe Marcel
Published: October 2019

Neste artigo, ancorados na Análise do Discurso (AD), pretendemos apresentar um panorama propositivo de nossas últimas reflexões e desenvolvimentos teórico-analíticos sobre as relações entre discurso, língua e cultura. Discurso, história, política, inconsciente e ideologia têm sido, todos, termos que fazem parte do aparato teórico da Análise do Discurso, que (se) reinterpreta (n)as contradições e lições de outros campos de estudo, pesquisa e reflexão, como o materialismo histórico, a psicanálise e a linguística, todos em profunda inter-relação nas décadas de 1960, 1970 e 1980. Aqui talvez materializemos mais um sintoma de que a Análise do Discurso tem se interessado, nos últimos tempos, pela noção de cultura. Nossa principal questão é: que noção de cultura para a AD, e que relações apresenta com a noção de língua? Para responder aos questionamentos, nos debruçamos sobre um fenômeno fundador das subjetividades nas diferentes formações sociais: o gesto de nomear sujeitos.
Língua de acolhimento e ensino de língua materna em periferias urbanas: uma reflexão discursiva
Authors: D'Olivo Fernanda Moraes , Trajano Raphael de Morais
Published: October 2019

Neste artigo, buscamos compreender os sentidos produzidos pela língua na sua relação com os sujeitos em duas situações: ensino de português como língua materna na periferia de uma grande cidade e ensino de português como língua de acolhimento. A partir da perspectiva da Análise de Discurso Materialista e de trabalhos que consideram a língua com base em uma visão discursiva, iremos refletir sobre processos de tensão e resistência dos sujeitos – sejam eles advindos de periferias ou de situações de refúgio – em relação à língua que lhes é ensinada.