bluuebunny/crossref_metadata_2025 huggingface dataset:
Osmotically assisted reverse osmosis, simulated to achieve high solute concentrations, at low energy consumption
Authors: H. M. Beigi Behzad , Gadkari Siddharth , Sadhukhan Jhuma
Published: August 2022

Microbial electrosynthesis (MES), is an emerging technology, for sustainable wastewater treatment. The dilute acetate solution, produced via MES, must be recovered, as dilute solutions can be expensive to store and transport. The acetate is expensive and environmentally damaging to recover by heat-intensive evaporative methods, such as distillation. In pursuit of a better energy economy, a membrane separation system is simulated to raise the concentration from 1 to 30 wt%, at a hydraulic pressure of approximately 50 bar. The concentrate is then simulated to be heat dried. Reverse osmosis (RO) could rase the acetate concentration to 8 wt%. A novel adaptation of osmotically assisted reverse osmosis (OARO) is then simulated to increase the concentration from 8 to 30 wt%. The inclusion of OARO, rather than a standalone RO unit, reduces the total heat and electric power requirement by a factor of 4.3. It adds to the membrane area requirement by a factor of 6. The OARO simulations are conducted by the internal concentration polarisation (ICP) model. Before the model is used, it is fitted to OARO experimental data, obtained from the literature. Membrane structure number of 701 µm and permeability coefficient of 2.51 L/m2/h/bar are ascertained from this model fitting exercise.
Oral sorafenib-loaded microemulsion for breast cancer: evidences from the in-vitro evaluations and pharmacokinetic studies
Authors: Chaurawal Nishtha , Misra Charu , Abul Barkat Harshita , Jatyan Reena , Chitkara Deepak , Barkat Md. Abul , Sharma Teenu , Singh Bhupinder , Raza Kaisar
Published: August 2022

Sorafenib tosylate (SFB) is a multikinase inhibitor that inhibits tumour growth and proliferation for the management of breast cancer but is also associated with issues like toxicity and drug resistance. Also, being a biopharmaceutical class II (BCS II) drug, its oral bioavailability is the other challenge. Henceforth, this report intended to encapsulate SFB into a biocompatible carrier with biodegradable components, i.e., phospholipid. The microemulsion of the SFB was prepared and characterized for the surface charge, morphology, micromeritics and drug release studies. The cell viability assay was performed on 4T1 cell lines and inferred that the IC50 value of sorafenib-loaded microemulsion (SFB-loaded ME) was enhanced compared to the naïve SFB at the concentrations of about 0.75 µM. More drug was available for the pharmacological response, as the protein binding was notably decreased, and the drug from the developed carriers was released in a controlled manner. Furthermore, the pharmacokinetic studies established that the developed nanocarrier was suitable for the oral administration of a drug by substantially enhancing the bioavailability of the drug to that of the free SFB. The results bring forth the preliminary evidence for the future scope of SFB as a successful therapeutic entity in its nano-form for effective and safer cancer chemotherapy via the oral route.
BDNF, proBDNF and IGF-1 serum levels in naïve and medicated subjects with autism
Authors: Robinson-Agramonte Maria de los Angeles , Michalski Bernadeta , Vidal-Martinez Belkis , Hernández Leyanis Ramos , Santiesteban Mabel Whilby , Fahnestock Margaret
Published: August 2022

Brain-derived neurotrophic factor (BDNF) and insulin-like growth factor 1 (IGF-1) promote the development and maintenance of neural circuits. Alterations in these factors might contribute to autism spectrum disorder (ASD). We asked whether serum BDNF, proBDNF, and IGF-1 levels are altered in an ASD population compared to controls. We measured serum BDNF, proBDNF, and IGF-1 immunoreactive protein in boys and girls aged 5–15 years old with mild to moderate ASD and non-autistic controls by ELISA. IGF-1 was increased in ASD serum compared to controls and was correlated with age and with CARS scores. Serum BDNF levels did not differ between groups, however, proBDNF serum levels were decreased in subjects with ASD compared to non-autistic controls. Medicated, but not unmedicated, ASD subjects exhibited lower serum proBDNF levels compared to controls, while neither IGF-1 nor BDNF levels differed between treatment groups. These data support the involvement of proBDNF and IGF-1 in the pathogenesis and treatment of autism.
Risk assessment of interstate pipelines using a fuzzy-clustering approach
Authors: Osman A. , Shehadeh M.
Published: August 2022

Interstate pipelines are the most efficient and feasible mean of transport for crude oil and gas within boarders. Assessing the risks of these pipelines is challenging despite the evolution of computational fuzzy inference systems (FIS). The computational intricacy increases with the dimensions of the system variables especially in the typical Takagi–Sugeno (T–S) fuzzy-model. Typically, the number of rules rises exponentially as the number of system variables increases and hence, it is unfeasible to specify the rules entirely for pipeline risk assessments. This work proposes the significance of indexing pipeline risk assessment approach that is integrated with subtractive clustering fuzzy logic to address the uncertainty of the real-world circumstances. Hypothetical data is used to setup the subtractive clustering fuzzy-model using the fundamental rules and scores of the pipeline risk assessment indexing method. An interstate crude-oil pipeline in Egypt is used as a case study to demonstrate the proposed approach.
Effects of decadal climate variability on spatiotemporal distribution of Indo-Pacific yellowfin tuna population
Authors: Wu Yan-Lun , Lan Kuo-Wei , Evans Karen , Chang Yi-Jay , Chan Jui-Wen
Published: August 2022

Spatial variations in tuna population and abundance are strongly linked to large-scale climate fluctuations, such as the Pacific decadal oscillation (PDO) and Atlantic multidecadal oscillation (AMO). However, the mechanisms underlying the association of climate indices with yellowfin tuna (YFT) abundance and habitat preference remain unclear. We analysed long-term longline fishery data for YFT and oceanic climate variability index data for 1971–2018. The standardized catch per unit effort (CPUE) of Indo-Pacific Ocean YFT was higher during negative AMO and positive PDO phases. In tropical Pacific Ocean, the trend of YFT habitat preference exhibited seesaw patterns because of the distinct environmental factors influenced by the PDO phase. The PDO changed the environmental parameters throughout the tropical Indian Ocean such that the habitat preference of YFT remained consistent throughout. However, the variations in habitat suitability did not correspond to the distribution or standardized CPUE of YFT throughout the Pacific Ocean during AMO events. Moreover, the changes in habitat suitability had a positive periodicity of 8–16 years with AMO in the Indian Ocean, but revealed opposite trends with the distribution or standardized CPUE of YFT. Our results provide sufficient information to distinguish the variations between PDO phase changing and YFT standardized CPUE/ habitat preference. Furthermore, the AMO phase shift period 60–100 years longer than that of the PDO (20–30 years), and models employing time series of fishery and environmental data must be extended the time period of our study to make the AMO match the fishery data more complete.
Evaluation of the interventions on HIV case management and its association with cART adherence and disclosure of the disease status among HIV-positive adults under treatment
Authors: Tegegne Awoke Seyoum , Zeru Melkamu A.
Published: August 2022

The rate of prevalence of HIV among adults has been increasing in sub-Saharan African countries over the last decade. The objective of this study was to evaluate the interventions on HIV case management based on cART adherence and disclosure of HIV disease status among HIV-positive adults under treatment. A retrospective cohort longitudinal data was conducted on 792 randomly selected patients in the study area. Engagement of HIV-positive persons into care and achieving treatment outcomes such as the disclosure of HIV status and cART adherence were fundamental for HIV prevention strategy. The two response variables under the current investigation were evaluation of intervention on HIV case management interims cART adherence and disclosure of HIV status. Binary logistic regression was conducted for separate models. Among the predictors, age of patients (AOR = 1.020, 95% CI (1.016, 1.191); p value = 0.005), the number of follow-up (AOR = 1.014, 95% CI (1.023, 1.030); p value < 0.0001). CD4 cell count (AOR = 0.981; 95% CI (0.765, 0.971), p value < 0.01), Marital status (AOR = 1.013; 95% CI (1.002, 1.015), p value = 0.006), female patients (AOR = 1.014; 95% CI (1.001, 1.121), p value < 0.007), rural (AOR = 0.982; 95% CI (0.665, 0.998), p value = 0.004), non-educated adult patients (AOR = 0.950, 95% CI (0.92. 0.98). p value = 0.003), Non-existence of social violence (AOR = 1.012, 95% CI (1.008, 1.234), p value < 0.01), adult with non-opportunistic diseases (AOR = 1.021, 95% CI (1.002. 1.042). p value = 0.001) significantly affected the two response variables jointly. Interventions on HIV case management lead to an efficient continuum of successful treatment outcomes like disclosure of HIV status and cART adherence. Hence, HIV case management intervention and the two results had a positive association. HIV case management intervention should be given to younger patients, rural residents, and non-educated patients to disclose the disease status and to have a long life with the virus. Health-related education should be conducted for the community in general and for patients in particular on how HIV is transferred from an infected person to an uninfected one. This helps to reduce the stigma of patients and to deliver social support to patients.
A real world analysis of COVID-19 impact on hospitalizations in older adults with chronic conditions from an Italian region
Authors: Bosetti Cristina , Rognoni Magda , Ciampichini Roberta , Paroni Luca , Scala Marco , d’Oro Luca Cavalieri , Zucchi Alberto , Amerio Andrea , Iacoviello Licia , Ghislandi Simone , Odone Anna , Stuckler David , Gallus Silvano ,   Lost in Lombardia Project Investigators, Bosetti Cristina , Gallus Silvano , Jarach Carlotta Micaela , Lugo Alessandra , Stival Chiara , Amerio Andrea , Amore Mario , Serafini Gianluca , De Sena Roberto , Ghislandi Simone , Stuckler David , Wang Yuxi , Bonaccio Marialaura , Gianfagna Francesco , Iacoviello Licia , Mosconi Giansanto , Odone Anna , Signorelli Carlo , Vigezzi Giacomo , d’Oro Luca Cavalieri , Paroni Luca , Sala Marco , Rognoni Magda , Ciampichini Roberta , Zucchi Alberto
Published: August 2022

Healthcare delivery reorganization during the COVID-19 emergency may have had a significant impact on access to care for older adults with chronic conditions. We investigated such impact among all adults with chronic conditions aged ≥ 65 years, identified through the electronic health databases of two local health agencies—ATS Brianza and ATS Bergamo—from the Lombardy region, Italy. We considered hospitalizations for 2020 compared to the average 2017–2019 and quantified differences using rate ratios (RRs). Overall, in 2017–2019 there were a mean of 374,855 older adults with  ≥ 1 chronic condition per year in the two ATS and 405,371 in 2020. Hospitalizations significantly decreased from 84,624 (225.8/1000) in 2017–2019 to 78,345 (193.3/1000) in 2020 (RR 0.86). Declines were reported in individuals with many chronic conditions and for most Major Diagnostic Categories, except for diseases of the respiratory system. The strongest reductions were observed in hospitalizations for individuals with active tumours, particularly for surgical ones. Hospitalization rates increased in individuals with diabetes, likely due to COVID-19-related diseases. Although determinants of the decrease in demand and supply for care among chronic older adults are to be further explored, this raises awareness on their impacts on chronic patients’ health in the medium and long run.
Genetic dissection of nitrogen induced changes in the shoot and root biomass of spinach
Authors: Joshi Vijay , Shi Ainong , Mishra Amit Kumar , Gill Haramrit , DiPiazza James
Published: August 2022

Efficient partitioning of above and below-ground biomass in response to nitrogen (N) is critical to the productivity of plants under sub-optimal conditions. It is particularly essential in vegetable crops like spinach with shallow root systems, a short growth cycle, and poor nitrogen use efficiency. In this study, we conducted a genome-wide association study (GWAS) to explore N-induced changes using spinach accessions with diverse genetic backgrounds. We evaluated phenotypic variations as percent changes in the shoot and root biomass in response to N using 201 spinach accessions grown in randomized complete blocks design in a soilless media under a controlled environment. A GWAS was performed for the percent changes in the shoot and root biomass in response to N in the 201 spinach accessions using 60,940 whole-genome resequencing generated SNPs. Three SNP markers, chr4_28292655, chr6_1531056, and chr6_37966006 on chromosomes 4 and 6, were significantly associated with %change in root weight, and two SNP markers, chr2_18480277 and chr4_47598760 on chromosomes 2 and 4, were significantly associated with % change shoot weight. The outcome of this study established a foundation for genetic studies needed to improve the partitioning of total biomass and provided a resource to identify molecular markers to enhance N uptake via marker-assisted selection or genomic selection in spinach breeding programs.
Iridoid glycoside Aucubin protects against nonylphenol-induced testicular damage in male rats via modulation of steroidogenic and apoptotic signaling
Authors: Hassan Israr UL , Ehsan Nazia , Ijaz Muhammad Umar , Afsar Tayyaba , Amor Houda , Almajwal Ali , Razak Suhail
Published: August 2022

Aucubin (AU) is one of the widespread compounds belonging to the group of iridoid glycosides, which possesses numerous beneficial properties. Nonylphenol (NP), is a synthetic environmental toxicant that has the potential to cause male infertility through excessive production of reactive oxygen species. In the current study, the remedial potential of Aucubin was assessed against NP-generated testicular damage in male rats. Animals were distributed into four groups and treated for 56 days in this study. Control-group (0.1% DMSO + food), NP group (100 µg/kg), NP + AU group (100 µg/kg + 5 mg/kg) and AU group (5 mg/kg). NP exposure significantly (p < 0.05) reduced the activity of antioxidant enzymes i.e., glutathione reductase, catalase (CAT), superoxide dismutase, glutathione peroxidase (GPx), and total protein content (TPC), whereas the level of reactive oxygen species (ROS) and thiobarbituric acid reactive substances (TBARS) was enhanced substantially (p < 0.05). Treatment with AU substantially (p < 0.05) recovered activities of antioxidant enzymes, TPC, ROS, and TBARS levels. Moreover, decrease in the levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), plasma testosterone, sperm count, motility, sperm membrane integrity, and the number of spermatocytes of different stages along with the level of steroidogenic enzymes i.e., 17β-hydroxysteroid dehydrogenase (17β-HSD), 3β-hydroxysteroid dehydrogenase (3β-HSD), and B-cell lymphoma 2 (Bcl-2) by NP administration were recovered to control values by AU treatment. However, AU mitigated the sperm abnormalities (head/midpiece/tail), the number of dead sperms, and proapoptotic proteins i.e., Bcl-2 associated X protein (Bax), caspase-9, and caspase-3 that were increased by NP. Besides, AU treatment recovered the NP-induced potential histopathological alterations in the testicular tissues such as the height of epithelium, seminiferous tubules diameter as well as the height of tunica propria. Overall, NP-induced toxicity was effectively recuperated by the AU administration. These results indicate that AU might be considered as a potential protective agent against testicular damage. The observed protection may be due to its antioxidant, anti-apoptotic, anti-inflammatory and androgenic potential.
Staphylococcal superantigen-like protein 10 induces necroptosis through TNFR1 activation of RIPK3-dependent signal pathways
Authors: Jia Nan , Li Guo , Wang Xing , Cao Qing , Chen Wanbiao , Wang Chengliang , Chen Ling , Ma Xiaoling , Zhang Xuan , Tao Yue , Zang Jianye , Mo Xi , Hu Jinfeng
Published: August 2022

Staphylococcal aureus(S. aureus) infection can lead to a wide range of diseases such as sepsis and pneumonia. Staphylococcal superantigen-like (SSL) proteins, expressed by all knownS. aureusstrains, are shown to be involved in immune evasion duringS. aureusinfection. Here, we show that SSL10, an SSL family protein, exhibits potent cytotoxicity against human cells (HEK293T and HUVEC) by inducing necroptosis upon binding to its receptor TNFR1 on the cell membrane. After binding, two distinct signaling pathways are activated downstream of TNFR1 in a RIPK3-dependent manner, i.e., the RIPK1-RIPK3-MLKL and RIPK3-CaMKII-mitochondrial permeability transition pore (mPTP) pathways. Knockout ofssl10inS. aureussignificantly reduces cytotoxicity of the culture supernatants ofS. aureus, indicating that SSL10 is involved in extracellular cytotoxicity during infection. We determined the crystal structure of SSL10 at 1.9 Å resolution and identified a positively charged surface of SSL10 responsible for TNFR1 binding and cytotoxic activity. This study thus provides the description of cytotoxicity through induction of necroptosis by the SSL10 protein, and a potential target for clinical treatment ofS. aureus-associated diseases.
IL-1-dependent enteric gliosis guides intestinal inflammation and dysmotility and modulates macrophage function
Authors: Schneider Reiner , Leven Patrick , Mallesh Shilpashree , Breßer Mona , Schneider Linda , Mazzotta Elvio , Fadda Paola , Glowka Tim , Vilz Tim O. , Lingohr Philipp , Kalff Jörg C. , Christofi Fievos L. , Wehner Sven
Published: August 2022

Muscularis Externa Macrophages (ME-Macs) and enteric glial cells (EGCs) are closely associated cell types in the bowel wall, and important interactions are thought to occur between them during intestinal inflammation. They are involved in developing postoperative ileus (POI), an acute, surgery-induced inflammatory disorder triggered by IL-1 receptor type I (IL1R1)-signaling. In this study, we demonstrate that IL1R1-signaling in murine and human EGCs induces a reactive state, named enteric gliosis, characterized by a strong induction of distinct chemokines, cytokines, and the colony-stimulating factors 1 and 3. Ribosomal tagging revealed enteric gliosis as an early part of POI pathogenesis, and mice with an EGC-restricted IL1R1-deficiency failed to develop postoperative enteric gliosis, showed diminished immune cell infiltration, and were protected from POI. Furthermore, the IL1R1-deficiency in EGCs altered the surgery-induced glial activation state and reduced phagocytosis in macrophages, as well as their migration and accumulation around enteric ganglia. In patients, bowel surgery also induced IL-1-signaling, key molecules of enteric gliosis, and macrophage activation. Together, our data show that IL1R1-signaling triggers enteric gliosis, which results in ME-Mac activation and the development of POI. Intervention in this pathway might be a useful prophylactic strategy in preventing such motility disorders and gut inflammation.
On the Molecular Basis of Cellular Mechanobiology
Authors: La Cruz Jorge Oliver-De , Martino Fabiana , Pagliari Stefania , Forte Giancarlo
Published: August 2022

The tight regulation of cell function in vivo requires the integration of biological and mechanical signals, as evoked by the surrounding extracellular matrix (ECM) or by neighboring cells. In this chapter, we describe the current understanding of the intracellular molecular processes through which physical cues generated at the ECM are turned into a biological response. These processes, which are the subject of intense investigation in the interdisciplinary field of mechanobiology, are needed for cellular timely adaptation to the continuous dynamic modifications of the microenvironment. By starting from the most recent findings in the field, we conceive a centripetal model of mechanotransduction whereby macromolecular complexes sitting at the interphase between ECM and the cell cytoplasm serve as the primary hub for the cell to perceive mechanical stress. Following the prompt rearrangement of the cellular membrane and focal adhesions, the inward transmission of the mechanical signal is ensured by the dynamic fine-tuning of cytoskeleton tension and the linker of nucleoskeleton and cytoskeleton (LINC) complex, the latter spanning through the nuclear envelope and thus bridging ECM-generated signals to the nucleus. LINC rearrangement deforms the nucleus, hence making cryptic DNA domains accessible to stage-specific transcription factors, whose activity is instructed by shuttling mechanosensitive cofactors.
A Comparative Study of 0D, 1D, and 2D Nanocatalysts Towards CO2 Conversion
Authors: Mandal Arindam , Roy Subhasis
Published: August 2022

In the twentyfirst century global energy crises have opened up research into alternative energy sources, among which electrochemical CO2 conversion into chemicals and fuels like methanol, ethanol, methane, etc., using semiconductor nano dimensional metal oxides is accepted as a valid method. Photocatalytic reduction of CO2 into solar fuels is also recognized as an attractive approach to solving the environmental and energy crises. In this field, 2D transition metal oxides have attracted significant attention in CO2 conversion into chemicals and fuels owing to their remarkable properties. In this chapter, a comparative study of 0D, 1D, and 2D nanocatalysts towards CO2 conversion and improvement of the electrochemical CO2 conversion system's efficiency is demonstrated. Detailed designs of various dimensional nanocomposite systems and their functional criteria, as well as electrical and mechanical properties which act as electrochemical catalysts for CO2 conversion into chemicals and fuels, are described thoroughly. The unique mechanical, electrical, surface charge density, and optical properties of nanomaterials make it possible to create heterojunction photocatalyst with complex structures of energy zones, permitting a wide range of visible light spectra and showing the positive effects on the absorption of visible light. This chapter also highlights the mechanism of photoelectrochemical CO2 conversion into chemicals and fuels and the enhancement of the yield of the CO2 converted high value-added products with various 0D, 1D, and 2D nanostructured materials. In brief, this chapter deals with a comparative study rationally designing and synthesizing nano-dimensional metal oxide photocatalysts toward high‐efficiency photoreduction of CO2.
A 3D-printed, multi-modal microfluidic device for measuring nitric oxide and ATP release from flowing red blood cells
Authors: Hayter Elizabeth A. , Azibere Samuel , Skrajewski Lauren A. , Soule Logan D. , Spence Dana M. , Martin R. Scott
Published: August 2022

A 3D-printed multi-modal device was developed to simultaneously detect nitric oxide (NO) and adenosine triphosphate (ATP) in red blood cell suspensions.
Enhanced detection of ascorbic acid with cascaded fluorescence recovery of a dual-nanoquencher system
Authors: Liu Zhi-Ang , Zuo Ya-Nan , Xia Yinghui , Sun Jing , Zhu Shuyun
Published: August 2022

An innovative fluorescence method has been proposed for enhanced detection of AA based on target-triggered cascade fluorescence recovery of a dual-nanoquencher system.
Non-targeted metabolomic analysis of variation of volatile fractions of ginseng from different habitats by HS-SPME-GC-MS coupled with chemometrics
Authors: Gu Wen-Ting , Li Lin-Yuan , Rui Wen-Jing , Diao Zhong-Wen , Zhuang Guo-Dong , Chen Xiao-Mei , Qian Zheng-Ming , Wang Shu-Mei , Tang Dan , Ma Hong-Yan
Published: August 2022

Cultivated ginseng (CG), transplanted ginseng (TG) and mountain cultivated ginseng (MCG) classified by the habitat type all belong to Panax ginseng and were reported to have similar types of secondary metabolites.
Preparation of P-doped CdS nanorods as an efficient photocatalyst for the degradation of the emerging pollutant tetracycline antibiotic under blue LED light irradiation
Authors: Das Sankar , Ahn Young-Ho
Published: August 2022

Here, we have fabricated P-doped CdS (CdS-P0.8) nanorods (NRs) by one-step thermal phosphorization treatment for TC degradation through photocatalytic reaction in the presence of blue and white LED light irradiation.
Ecological and human health risks of atmospheric microplastics (MPs): a review
Authors: Yao Xuewen , Luo Xiao-San , Fan Jiayi , Zhang Tingting , Li Hanhan , Wei Yaqian
Published: August 2022

Microplastics (MPs) in the atmosphere are ubiquitous and persistent emerging pollutants which have been an environmental issue of global concern.
Extraction optimization, structural characterization and potential alleviation of hyperuricemia by flavone glycosides from celery seeds
Authors: Zhang Chao , Zhao Ming , Jiang Bei , Yu Jing , Hao Qiufa , Liu Wenxuan , Hu Zhao , Zhang Youming , Song Chun
Published: August 2022

Celery seeds are commonly used as condiments and in herbal teas with high medicinal value.
Polyoxometalate intercalated MXene with enhanced electrochemical stability
Authors: Zhu Jun-Jie , Gomez-Romero Pedro
Published: August 2022

Keggin polyanions were successfully intercalated within MXene layers thanks to the pre-intercalation of long CTA cations which provide an extra expansion of the interlayer distance and suitable anchoring sites through effective charge shielding.
Controllable synthesis of magic cube-like Ce-MOF-derived Pt/CeO2 catalysts for formaldehyde oxidation
Authors: Guo Zeyi , Zhao Xiuxian , Chen Guozhu , Zhao Wei , Liu Tongyao , Hu Riming , Jiang Xuchuan
Published: August 2022

A magic cube-like NH2-Ce-BDC is prepared, and its derived CeO2 has demonstrated to be a good support for ALD-prepared Pt for catalyzing HCHO oxidation.
Highly fluorescent purine-containing conjugated copolymers with tailored optoelectronic properties
Authors: O'Connell C. Elizabeth , Sabury Sina , Jenkins J. Elias , Collier Graham S. , Sumpter Bobby G. , Long Brian K. , Kilbey S. Michael
Published: August 2022

Conjugated copolymers containing electron donor and acceptor units in their main chain have emerged as promising materials for organic electronic devices due to their tunable optoelectronic properties.
The role of electrochemical biosensors in SARS-CoV-2 detection: a bibliometrics-based analysis and review
Authors: Mao Shudan , Fu Li , Yin Chengliang , Liu Xiaozhu , Karimi-Maleh Hassan
Published: August 2022

This review describes for the first time the role played by electrochemical biosensors in SARS-CoV-2 detection from a bibliometric perspective.
Nickel-catalyzed arylative substitution of homoallylic alcohols
Authors: Tran Hai N. , Nguyen Chau M. , Koeritz Mason T. , Youmans Dustin D. , Stanley Levi M.
Published: August 2022

Arylative substitutions of homoallylic alcohols with arylboron nucleophiles demonstrate the utility of unactivated alcohols as coupling partners in transition metal-catalyzed cross-coupling chemistry.
Aromatic heterobicycle-fused porphyrins: impact on aromaticity and excited state electron transfer leading to long-lived charge separation
Authors: Moss Austen , Jang Youngwoo , Arvidson Jacob , Nesterov Vladimir N. , D'Souza Francis , Wang Hong
Published: August 2022

π-Extended porphyrins fused with benzo[4,5]imidazo[2,1-a]isoindole, showing unique electronic and photophysical properties, were newly synthesized. A long-lived charge-separated state was revealed upon coordination of C60to zinc porphyrin AMIm-2.
A CRISPR/Cas12a-responsive dual-aptamer DNA network for specific capture and controllable release of circulating tumor cells
Authors: Wang Dong-Xia , Wang Jing , Wang Ya-Xin , Ma Jia-Yi , Liu Bo , Tang An-Na , Kong De-Ming
Published: August 2022

The separation and detection of circulating tumor cells (CTCs) have a significant impact on clinical diagnosis and treatment by providing a predictive diagnosis of primary tumors and tumor metastasis.
Unraveling hydridic-to-protonic dihydrogen bond predominance in monohydrated dodecaborate clusters
Authors: Jiang Yanrong , Yuan Qinqin , Cao Wenjin , Hu Zhubin , Yang Yan , Zhong Cheng , Yang Tao , Sun Haitao , Wang Xue-Bin , Sun Zhenrong
Published: August 2022

A joint gas-phase ion spectroscopic and multiscale theoretical study reveals unequivocally the predominance of the hydridic-to-protonic dihydrogen bond over the prototypical strong hydrogen bond in monohydrated dodecaborate clusters.
Spontaneous solid electrolyte interface formation in uncycled sodium half-cell batteries: using X-ray photoelectron spectroscopy to explore the pre-passivation of sodium metal by fluoroethylene carbonate before potentials are applied
Authors: Gimble Nathan J. , Prieto Amy L.
Published: August 2022

Testing sodium battery technology relies on a half-cell setup with sodium metal as the counter electrode. The sodium metal is shown to affect the working electrode by reacting with the electrolyte.
Robust folding of elastic origami
Authors: Lee-Trimble M. E. , Kang Ji-Hwan , Hayward Ryan C. , Santangelo Christian D.
Published: August 2022

Using a model for self-folding origami with both stretching and bending deformations and with experimental verification, we show that the finite elasticity of an origami, despite typically contributing to misfolding, can be utilized to prevent it.
Polymorphic self-assembly of helical tubules is kinetically controlled
Authors: Fang Huang , Tyukodi Botond , Rogers W. Benjamin , Hagan Michael F.
Published: August 2022

Dynamical simulations, free energy calculations, and analytical theory of helical tubule self-assembly show that the morphology distribution of assembled tubules is kinetically controlled.
Evolution of fluoride shuttle battery reactions and three-dimensional morphology changes of BiF3 microparticles in an ethylene carbonate-based liquid electrolyte
Authors: Yamanaka Toshiro , Ogumi Zempachi , Abe Takeshi
Published: August 2022

Fluoride shuttle battery reactions of BiF3 microparticles were observed in an ethylene carbonate-based electrolyte. The reaction mechanisms and rate-determining steps were elucidated.
Improving the mechanical properties of jute fiber woven mat reinforced epoxy composites with addition of zinc oxide filler
Authors: Sathishkumar T P , Rajeshkumar L , Rajeshkumar G , Sanjay M R , Siengchin Suchart , Thakrishnan Navanee
Published: August 2022

The present work is to prepare the jute fiber reinforced epoxy composites by changing the number of layers of jute fiber mat and adding the various content of zinc oxide filler. The composites were prepared by compression molding techniques and investigates the tensile, flexural and impact properties according to ASTM standard. The results reveal that increasing the number of jute fiber mat layer was increased the mechanical properties. The maximum strength was obtained in double-layer composites. By incorporation of zinc oxide filler, the filler content gradually increased the mechanical strengths which increased the bonding effect between fiber and matrix. The maximum mechanical strengths were obtained for composites containing the 25% of zinc oxide filler. More than the 25% of zinc oxide filler was decreased the mechanical properties due to lower the resin content and bonding between fiber and matrix.
Study of the Titanium Dioxide Nanoparticles Used as UV absorber on Natural Herbal Extract Sunscreen Products
Authors: Wirunchit Supamas , Sakulpeeb Natchayaporn , Koetniyom Wantana
Published: August 2022

This research focuses on the effects of UV absorber on natural herbal extracts including Wan Nga-chang (Ivory) and Wan Tan-diao containing Glycoside and Tannin with solvent prepared via the maceration method. The concentrations of UV absorber in this study, Titanium Dioxide (TiO2), were varied from 5, 10, 15 % by weight and compared to the unadded reference material. The characteristics and properties of sunscreen products were analyzed by UV-Vis spectroscopy, X-ray diffraction technique (XRD) and Fourier Transform-Infrared spectrometer (FT-IR). The results of the experiment showed that the optimal concentration of UV absorber is herbal cream and TiO2 at concentrations of 10%wt. From XRD and FT-IR techniques confirmed the elements and functional group of herbal extract and TiO2, respectively.
Decision support system for consumer behavior of Elderly Chinese tourists on healthy beverages
Authors: Pichitkarnkar Thanyathip , Kengpol Athakorn
Published: August 2022

Based on tourist expenditure, food and beverages are a crucial market and healthy beverages are a dominant product developed to serve customer needs. At present, elderly tourist groups emerge with purchasing power in the tourism industry and related businesses. However, market and academic research on healthy beverages still need further knowledge and only a few decision support models exist. The objectives of this research are (1) to investigate major influential factors of consumer behavior (CB) of elderly Chinese tourists on healthy beverages; and (2) to structure a decision support system for CB. The research methodology employs qualitative and quantitative approaches. In-depth interviews are conducted by including 120 experts with 410 survey samples collected from Chinese tourists. Content analysis and structural equation modelling (SEM) are employed to analyze the data, including the sensitivity analysis for testing model robustness. The results show that marketing stimuli affect CB and product innovation at a significant level of 0.05. On the other hand, product innovation slightly affects CB at a significant level. The sensitivity analysis reveals that decreasing price and trial usage are influential CB. Also, the increasing and decreasing of attitude, relative advantage, and compatibility affect CB. This research aims to design an applicable decision support system of CB for Chinese tourists, which can identify influential factors of CB on healthy beverages when an entrepreneur launches a new product and be a guideline for SMEs to assess customer satisfaction by responding directly to customer needs. Moreover, the DSS model can also enable sustainable development and engage the right business strategies that resonate with customer needs.
Effect of pepsin on antioxidant and antibacterial activity of protein hydrolysate from salted jellyfish (Lobonema smithii and Rhopilema hispidum) by-products
Authors: Muangrod Pratchaya , Charoenchokpanich Wiriya , Roytrakul Sittiruk , Rungsardthong Vilai , Vatanyoopaisarn Savitri , Charoenlappanit Sawanya , Wonganu Benjamaporn , Thumthanaruk Benjawan
Published: August 2022

Protein hydrolysates are products of protein degradation that provide various sizes of peptides and free amino acids. Protein hydrolysate from the different types of enzymes and raw materials provides different bioactivity, such as antioxidant and antibacterial activity. Salted jellyfish by-products have the potential to be a source for protein hydrolysate production because of their low price and having collagen protein. This research aimed to evaluate the antioxidant and antibacterial activity of protein hydrolysates from jellyfish by-products. The dried salted jellyfish by-products from the umbrella and oral arm part of white-type (Lobonema smithii) and sand-type (Rhopilema hispidum) were desalted and enzymatically hydrolyzed by 5% (w/w) pepsin for 24 h at 37°C. Bioactivity assays showed that the hydrolysate of the oral arms part of white-type jellyfish exhibited the highest antioxidant activity (13.27%). While protein hydrolysate of umbrella part of sand-type jellyfish showed the highest antibacterial activity against Vibrio parahaemolyticus up to 13.61%. The results demonstrated that peptic hydrolysate of different types and parts of jellyfish by-products provided different antioxidant or antibacterial activity, thereby increasing the potential uses of jellyfish protein hydrolysate as a functional food.
An update of serial interval estimates for COVID-19: a meta-analysis
Authors: Jusot Jean-François
Published: August 2022

Background: Serial interval (SI) is one of the most important parameter for COVID-19 modelling purposes as it is related to the reproduction rate of the infection. The first meta-analysis of serial interval were performed with a range of uncertainty in the estimate. This meta-analysis aimed to reduce the uncertainty estimates by assessing publications over a longer period.Methods: A literature search was performed for articles published between 1st December 2019 and 15th February 2022. It retrieved 117 eligible studies containing some 80 for 90 serial interval estimates. A random effects model was used. Heterogeneity was checked. To detect a publication bias, a funnel plot was performed using an Egger’s test.Results: For alpha variant, the serial interval was estimated at 5.17 days (95% CI = 4.87 – 5.47) with a significant heterogeneity (I2 = 97.1%). The meta-analysis did not exhibit evident publication bias (Egger’s test = −0.55,p = 0.58). The meta-analysis allowed for reducing uncertainty in estimating the serial interval, although subgroup analysis did not reduce it sufficiently and showed that studies using a gamma distribution of serial intervals exhibited the highest estimate of 5.6 days. Compared to the other variants of concern, alpha serial interval estimate was bigger than delta, 4.07 days, and omicron, 3.06 days.Conclusion: The meta-analysis was carried out as a real-time monitoring of this parameter to make a choice and a rapid assessment of the control measures implemented, and the effectiveness of the vaccination campaign. The meta-analysis was unable to provide a suitable estimate of serial intervals for COVID-19 modelling purposes although its uncertainty was reduced. Furthermore, serial intervals estimate for alpha variant was close to earlier reports and lower than previous publications, respectively. Another limitation is, that meta-analysis of COVID pandemic studies in principle contains and produces itself a significant source of heterogeneity.
The study of topside ionospheric irregularities during geomagnetic storms in 2015
Authors: Jimoh Oluwaseyi , Lei Jiuhou , Huang Fuqing , Zhong Jiahao
Published: August 2022

In this study, the variations of topside ionospheric irregularities during 24 geomagnetic storms with Dst ≤ −50 nT in 2015 were examined through an algorithm specifically designed to detect a significant level of ionospheric irregularities. The algorithm was developed through the use of several parameters derived from the topside total electron content (TEC) observations from GRACE, Swarm-C, and Swarm-B. The local time characteristics of the observed equatorial plasma irregularities (EPIs) were analyzed during different phases of the storms, within 30° S–30° N magnetic latitudes. By comparing its results with corresponding in-situ electron density data and the results of previous studies, the algorithm was found to be efficient. It was observed that the detected EPIs at different stages of the storm showed local time dependence. For instance, EPIs were observed during nighttimes, but took place in the daytime occasionally during the storm main phase. Furthermore, the percentage occurrence rates were most prominent during the main phase at the post-sunset sector within less than 6 h of the storm onset. On the other hand, the occurrence rates became prominent in the post-midnight/morning sector during the recovery phase and even higher than observed in the post-sunset sector. Based on these findings it was concluded that the dominant driver of the enhanced EPIs during the post-midnight/daytime sector could be associated with disturbance dynamo electric fields.
A PDE Approach to the Long-Time Asymptotic Solutions of Contact Hamilton-Jacobi Equations
Authors: WANG Yujie , LI Xia
Published: August 2022

We study the long-time asymptotic behaviour of viscosity solutions [see formula in PDF] of the Hamilton-Jacobi equation [see formula in PDF] in [see formula in PDF] with a PDE approach, where [see formula in PDF] is coercive in [see formula in PDF], non-decreasing in [see formula in PDF] and strictly convex in [see formula in PDF], and establish the uniform convergence of [see formula in PDF] to an asymptotic solution [see formula in PDF] as [see formula in PDF]. Moreover, [see formula in PDF] is a viscosity solution of Hamilton-Jacobi equation [see formula in PDF].
Improving the Efficiency of Multi-Objective Grasshopper Optimization Algorithm to Enhance Ontology Alignment
Authors: LV Zhaoming , PENG Rong
Published: August 2022

Ontology alignment is an essential and complex task to integrate heterogeneous ontology. The meta-heuristic algorithm has proven to be an effective method for ontology alignment. However, it only applies the inherent advantages of meta-heuristics algorithm and rarely considers the execution efficiency, especially the multi-objective ontology alignment model. The performance of such multi-objective optimization models mostly depends on the well-distributed and the fast-converged set of solutions in real-world applications. In this paper, two multi-objective grasshopper optimization algorithms (MOGOA) are proposed to enhance ontology alignment. One is ε-dominance concept based GOA (EMO-GOA) and the other is fast Non-dominated Sorting based GOA (NS-MOGOA). The performance of the two methods to align the ontology is evaluated by using the benchmark dataset. The results demonstrate that the proposed EMO-GOA and NS-MOGOA improve the quality of ontology alignment and reduce the running time compared with other well-known metaheuristic and the state-of-the-art ontology alignment methods.
Effects of Different Extinction for Morphine-CPP on Hippocampal EEG Power Spectrum in Mice
Authors: LI Chunchun , GAO Jingyao , WANG Xiaoqin , WANG Gongwu , CAO Jun
Published: August 2022

The relationship between hippocampal electroencephalogram (EEG) power spectrum and the extinction of addiction memory was investigated. Forty KM mice (Kunming mice) that had successfully established morphine (MOR)-conditioned place preference (CPP) were divided into four groups: saline-training extinction (SAL-TE), SAL-natural extinction (SAL-NE), MOR-TE, MOR-NE, for extinction treatment and EEG recording in the dorsal and ventral hippocampus (DH/VH). Results show that the CPP score of MOR-TE significantly decreased and the total, β and γ bands power spectrum of MOR-TE was suppressed. Notably, the total power from the VH was more correlated with the extinction method, and the TE total power was always lower than NE in SAL or MOR group. Naloxone enhanced the EEG total power and all bands (DH) or β and γ bands (VH) power in the SAL group. However, in the MOR-TE group, only β and γ bands power in VH increased (P<0.05). The results suggest that TE can promote the extinction of opiate addictive memory more effectively than NE, and the extinction of MOR-CPP may have a stronger correlation with changes of VH-EEG power spectrum.
Acute Mesenteric Ischemia
Authors: Lendzion Rebecca J. , Frahm-Jensen Gert , Keck James
Published: August 2022

The surgical treatment of occlusive acute mesenteric ischemia (AMI) without revascularization is associated with an 80% overall mortality. Early diagnosis is crucial, and revascularization may reduce overall mortality in AMI by up to 50%. A diagnosis of AMI requires a high index of clinical suspicion and the collaborative effort of emergency department physicians, general and vascular surgeons, and radiologists. This article provides an overview of the etiology, physiology, evaluation, and management of acute mesenteric ischemia.
Adoption of incentive-based insurance applications: the perspective of psychological ownership
Authors: Talonen Antti , Koskinen Lasse , Voutilainen Raimo , Talonen Harri
Published: August 2022

Incentive-based health insurance applications have been implemented to trigger lower insurance premiums when the individual follows healthy living habits. It has been recognised that this benefit notwithstanding, consumers’ perceptions related to such applications in the life-insurance field and health tracking are not necessarily positive. Recent research has recognised that psychological ownership, a mental state wherein one feels a technology or application to be his or her own, plays a crucial role in individuals’ willingness to adopt and use new technologies. It has been suggested that many digital applications and platforms possess unique empowering and co-creative features that offer special potential to facilitate the emergence of psychological ownership and satisfy the underlying needs. The aim of our study, proceeding from these premises, was to identify and thematize hurdles to take-up of incentive-based health insurance applications with regard to meeting needs that drive development of psychological ownership. We achieved this by conducting a thematic analysis of perceptions of consumers who were not willing to adopt a specific application of the relevant type. The resulting framework, which recognises 14 thematized hurdles in all, holds important implications for scientific and managerial use both.
Application and assessment of the improved delayed detached eddy simulation model to the cold spray process: Toward high fidelity computation fluid dynamics simulations
Authors: Bouthier Louis-Vincent , Delloro Francesco , Hachem Elie
Published: August 2022

Despite many years of research about the comprehension of fluid-dynamic related phenomena and improvements in the performance of cold spray systems, ensuring high fidelity simulations of gas and particle flow remains a challenge. In this work, a detailed high fidelity modeling, namely, improved delayed detached eddy simulation, in axisymmetric geometries was proposed and compared with a more usual numerical framework, the Reynolds averaged Navier–Stokes model. After its validation against literature data in three different nozzle configurations, the new model could demonstrate more accurate predictions of phenomena such as oblique shocks, bow shock, and particle–gas flow coupling. Finally, thanks to the high fidelity numerical framework, a new nozzle geometry with a narrower extension of the particle jet was proposed and assessed.