bluuebunny/crossref_metadata_2025 huggingface dataset:
In vitro antifungal activity of Candida culture extracts against Trichophyton rubrum and Trichophyton mentagrophytes.
Authors: Lemes Thiago Henrique , Torrezan Guilherme Silva , Polaquini Carlos Roberto , Regasini Luis Octavio , Almeida Bianca Gottardo de , Brizzotti-Mazuchi Natália Seron , Ribeiro Mariela Domiciano , Maschio-Lima Taiza , Caetano Maicon Henrique , Pattini Veridianna Camilo , Paziani Mario Henrique , Von Zeska Kress Marcia Regina , Siqueira João Paulo Zen , Almeida Margarete Teresa Gottardo
Published: November 2021

Onychomycoses are nail infections caused primarily by dermatophytes fungi, yeasts, and other filamentous fungi, characterized by persistent infections, prolonged therapy, and high recurrence rates. In clinical practice, some of these occurrences present two or more microorganisms, and the interactions among them can change the chemical environment mediated by small diffusible molecules, producing a competitive niche. The aim of this study was to evaluate the antifungal activity of individual extracts of pure cultures of Candida albicans and C. parapsilosis against dermatophytes. To obtain the fungal extracts, cultures were filtered through a 0.2 μm membrane and submitted to liquid-liquid extraction using ethyl acetate. The Minimal Inhibitory Concentration (MIC) of each extract was evaluated by broth microdilution method and checkerboard assay with fluconazole against clinical isolates of Trichophyton rubrum and T. mentagrophytes. The invertebrate model of Galleria mellonella was used to evaluate the toxicity of the extracts. As results, the extracts of C. albicans and C. parapsilosis showed antifungal activity with MICs between 31,2 – 2000 μg/mL. In association with fluconazole, synergistic effect was detected for all combinations. The extracts presented low toxicity in G. mellonella. In the future, isolation and identification of the extract compounds may allow new therapeutic approaches in the control of fungal infections.
Towards a Common Agricultural Data Space in the European Union: A Sustainable Development Perspective
Authors: Kosior Katarzyna
Published: November 2021

In February 2020 the European Commission announced a new strategy for data in which an innovative proposal to create a single European data space composed of many sectoral common data spaces, including the agriculture sector, was presented. It is expected that the common agricultural data space will provide support for delivering a smart, innovative and sustainable agri-food system from farm to fork. Based on the analysis of framework conditions for pooling and sharing agricultural data in the EU and the Commission’s initiatives in this area, this article aims to discuss how and to what extent the common data space in agriculture could contribute to environmental, economic and social sustainability in the EU. It was concluded that the achievement of sustainability goals with the help of the planned common data space remains challenging, particularly in the context of rapid, but uneven pace of digital transformation in the agri-food sector in the EU. Overcoming legal, technical and other barriers to data sharing in the EU will not remove the fundamental problems of limited representativeness of current agricultural data assets in the EU. The design of the common data space in agriculture as well as the rules for data access and use should therefore be carefully considered. Also, specific and datarelated intervention measures, e.g. under the CAP, would be needed both to decrease the problem of a fragmented farm data landscape and to respond to the growing needs to collect and share private farm data that are highly relevant to achieving broader social goals and sustainability.
Przemienność dochodów gospodarstw rolnych w Polsce w latach 2005–2018
Authors: Pawłowska Aleksandra , Rembisz Włodzimierz
Published: November 2021

W artykule dokonano oceny kształtowania się dochodów polskich producentów rolnych w latach 2005–2018, ze szczególnym zwróceniem uwagi na charakter tendencji zmian dochodów w kolejnych latach. Przeprowadzona analiza pozwoliła na wskazanie utrzymującej się wysokiej zmienności dochodów, zarówno na poziomie ogółu próby badawczej, jak i w poszczególnych klasach wielkości ekonomicznej. W przypadku gospodarstw o wielkości ekonomicznej od 8 do 500 tys. euro SO widoczny był wzrost dochodów w okresie 2005–2018, a sposób ich kształtowania się w kolejnych latach miał dodatkowo pewne cechy przemienności.
La granulomatosi eosinofilica con poliangioite: dalla pelle al cuore
Authors: Pavan Matteo , Agrusti Anna , Trombetta Andrea , Pastore Serena , Tommasini Alberto , Moressa Valentina , marchetti Federico , Taddio Andrea , Ventura Alessandro
Published: November 2021

Key words: Churg-strauss syndrome, Eosinophilic granulomatosis with polyangiitis in childhood, Vasculitis, Asthma, Hypereosinophilia Background - Eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, is an extremely rare systemic vasculitis in the paediatric population. The hallmarks of eosinophilic granulomatosis with polyangiitis are a long history of asthma and peripheral eosinophilia with eosinophilic inflammation that may involve several organs. Findings - The paper reports the clinical characteristics, courses, and outcomes of the four patients diagnosed with eosinophilic granulomatosis with polyangiitis at IRCCS Burlo Garofolo (Trieste, Italy) from 1996 to 2015. The mean age at diagnosis was 11.5 years. All the patients presented a history of asthma and peripheral eosinophilia at diagnosis. 3/4 of the children presented upper airway and pulmonary disease. Skin and heart involvement was present in half of the patients, whereas gastrointestinal and neurological symptoms were reported in 25% of the cases. When performed, tissue biopsy revealed eosinophilic inflammation in all the cases. Anti-neutrophil cytoplasmic antibodies were negative in 66% patients. One young child died shortly after presentation, one remitted after immunosuppressive treatment and two patients needed low-dose corticosteroid therapy to maintain the remission. Conclusion - Comparison with an updated review of the series and cases of childhood-onset eosinophilic granulomatosis with polyangiitis reported in the literature showed similar demographic characteristics, clinical features and outcomes. Cardiac disease represents the poorer prognostic factor, leading to the 60% of the deaths reported.
Ecografia con mezzo di contrasto in ambito pediatrico: uno sguardo al futuro
Authors: Basso Luca , Di Mascio Alberto , Di Leo Grazia
Published: November 2021

Over the past decade, the experience gained on the use of Contrast Enhancement Ultrasound (CEUS) and the increasing number of scientific publications about the topic have allowed this method to become an alternative to the traditional imaging methods, especially in paediatric Radiology. CEUS is a bedside ultrasound, radiation-free, repeatable and almost without risk of adverse reactions to the contrast. CEUS represent an additional weapon for diagnostic and follow-up purposes in the paediatric patient.
Up-dates on Cardio-Circulatory Support
Authors: Khan Niazi Attaullah , Stehli Julia , Muneeb Muhammad , Hameed Khan Ammar , Arif Ahsan
Published: November 2021

In-hospital mortality rates have approved in the recent past1 6 to 12-month death persists at approximately 50%2. The goal of treatment is to reestablish tissue perfusion while closely monitoring hemodynamics. Provisional automatic cardiovascular support is a mainstay of the management of patients who cannot be stabilized with medical therapy. Apart from the acute setting, automatic cardiovascular support is also used in the mid- and long-term treatment of heart failure patients. This can either be until heart transplant or life-long in patents who are not candidates for heart transplant. Further it is an essential tool of open-heart surgery. In the present review we will give an overview and update of the diﬀerent devices for mechanical cardiac support. Non-mechanical Cardio-Circulatory Support includes intravenous fluids and pharmacological treatment with vasopressors and inotropic agents. Norepinephrine is mainly a vasopressor, but also has other activities such as inotropy. It serves as first line agent, particularly in the acute setting of a cardiogenic shock. A recent randomized trial comparing Norepinephrine versus Epinephrine in cardiogenic shock after myocardial infarction found that Norepinephrine appeared to be a safer choice than Epinephrine3. Vasopressin causes less pulmonary vasoconstriction than norepinephrine and is therefore might better as a first line vasopressor compared to Norepinephrine4. Dobutamine, a beta agonist is frequently being used for cardiogenic shock, acting as inotropic agent. Levosimendan is a Calcium sensitizer and often used in patients with acute decompensation of chronic heart failure.
Patient Satisfaction Stratification in Inguinal Hernia Surgery Under Local Anesthesia –Experience of 650 Patients
Authors: Sher Zaman Balakh , Kamran Ch M. , Anwer M. Faheem , Majeed Shahid , Faisal Adnan , Zulfiqar M. Mubashir , Shahid Amna
Published: November 2021

Aim: To evaluate patient satisfaction undergoing inguinal hernia surgery under local anesthesia. Methods: The study was conducted in Jinnah hospital, Lahore from 2014 to 2019 including 650 clinically diagnosed patients with direct or indirect inguinal hernia with age ranging 20 to 60 years. All of these patients were operated in dedicated day care operation-theater of surgical department, where hernia surgeries under local anesthesia were done on daily basis 6 days a week. We assessed satisfaction in all patients undergoing inguinal hernia surgery with monitoring during anesthesia care known as iowa satisfaction with small anesthesia scale. Results: 80% of patients were between 20 to 45 years of age with male to female ratio 99: Right inguinal hernia patients were 55% and 45% with left inguinal hernia. In the proforma of 11 questionnaire, 96 % patients were found satisfied with the quality of anesthesia care with varying satisfactions ranging above 90 % regarding pain, feeling like throwing up, feeling relaxed as well as feeling hurt. Conclusion: Inguinal hernia surgery under local anesthesia is found profoundly satisfactory with regard to anesthetic care. Local anesthesia hernial surgery has satisfactory patient acceptability similar to those observed in a conventional regional/general anesthesia in tertiary care setup. Keywords: Inguinal hernia, local anaesthesia, satisfaction
Determination of Leptin Adiponectin, LDL/HDL ratio with substantial role of Adiponectin and its Receptor
Authors: Ali Talat Muhammad , Shoaib Muhammad , Sabir Sana , Mumtaz Uzair , Tauseef Ambreen , Akram Tanzeela , Iqbal Talat
Published: November 2021

Aim: To determine Leptin/Adiponectin ratio, LDL/HDL ratio and AdipoR1 in obese and healthy subjects along with their respective lipid status. Methods: This cross-sectional comparative study was conducted in Sialkot city. One hundred and thirty-two participants took part in this research. Participants were equally divided into two groups containing non-obese and obese subjects. Mean age was 39.6±0.97 years. Mean BMI for obese subjects was 31.55±0.6 while non-obese group BMI was 20.5±0.2. Individuals with conditions and history of drugs were excluded. Informed and written consent was obtained prior to fasting blood sampling. Serum extraction and proper storage for later testing was carried out. ELISA method used for Adiponectin, AdiopR1 and leptin estimations while lipid profile was determined by Randox Diagnostics kits, using micro lab. SPSS v. 26. was used for comparison between by Mann-Whitney U tes. Results: Higher levels of Leptin/Adiponectin ratio(0.85±0.1) and LDL/HDL ratio (3.39 ± 0.1), serum Adiponectin (545± 73.3 ug/L), leptin (320.7±50.3 pg/mL) and AdipoR1 (28.9± 2.8 ng/mL) in obese when compared with healthy individuals, Leptin/Adiponectin ratio (0.44 ± 0.07 ) and LDL/HDL ratio (2.56 ± 0.08) Adiponectin (834± 70.6 ug/L), AdiopoR1 (17.8± 1.97 ng/mL), leptin (224.4±168.7 pg/mL). Correlation of adiponectin found positive for AdipoR1(r=0.336,p<0.05) and Leptin(r=0263,p<0.05) in obese subjects. L/A ratio correlated positive with leptin (r=0.644,p<0.05) in obese while in healthy subjects (leptin r=0.409,p<0.05,adiponectin r=-0.408,p<0.05 and HDL r=0.266,p<0.05).. Conclusion: The Leptin/Adiponectin ratio was found higher in obese subjects 0.85 as compared to healthy ones 0.44. Also the LDL/HDL ratio was found higher (3.39) when compared to non-obese (2.56), suggesting these ratios as a suitable marker to estimate metabolic disturbances and underlying dyslipidemia in the obese subjects. Key Words: Adiponectin, LDL/HDL ratio, Leptin, Leptin/Adiponectin ratio, Obesity
Feedback of Certificate in Medical Teaching Programme at King Edward Medical University Lahore
Authors: Javed Salman , Ayyaz Mehwish , Adeel Bushra , Imran Andrabi Wajeeha , Khanum Amna , Khanum Fatima
Published: November 2021

Background: The concept of feedback is central to medical education. There is gradual shift from sandwich feedback to Pendleton feedback which is learner centred. Pragmatic worldview was proposed in this study. Certificate in Medical Teaching (CMT) programme was initiated at King Edward Medical University (KEMU) Lahore since 2019.The study objective was to improve learning outcome. Methods: Mixed Method research design was chosen, out of all mixed method procedures “Convergent parallel mixed method design” was followed collecting simultaneously quantitative and qualitative data, then results were analysed and compared separately. This study was carried out from 01-06-2020 to 31-03-2021 at King Edward Medical University Lahore. Sample size of 43 participants from CMT (Certificate in Medical Teaching) Batch 1 and 2 took part in this study. Doctors from clinical side, demonstrators and personnel of Allied health sciences attended this course. A predesigned proforma designed on google form was sent to each participant via e-mail.. Results: Quantitative data collected was interpreted as percentages and in form of tables and presented as pie charts. Qualitative data collected was analysed by segregating data into codes. Corresponding themes were made of each code and presented in tabular form. Conclusion: On the basis of feedback and mixed method approach, it can be concluded that certificate in medical teaching is a new teaching program at king Edward Medical University Lahore which can serve as basis to start master’s degree at this institution. Keywords: Feedback, medical teaching, KEMU
Effectiveness of Huffing Manoeuvre on Fentanyl Induced Cough
Authors: Faisal Mr. , Khan Mujeeb Ahmed , Nazir Nadir , Jamil Arsalan , Baloch Adnan Ali , Nasir Zaid Bin
Published: November 2021

Aim: To determine the effect of huffing manoeuvre to preventing cough caused by intravenous administration of fentanyl during induction of anaesthesia. Study Design: Cross-sectional study Place and duration of study: General Anaesthesia Department, SICU and Pain Management, Civil Hospital Karachi from 1st June 2019 to 30th November 2019. Methodology: One hundred and sixty four patients meeting were enrolled. Every patient was taught to perform huffing manoeuvre by primary investigator visiting patient in ward at night before surgery. The act of huffing manoeuvre was lasts within 5 seconds. Any episode of cough within 60 seconds of fentanyl administration was classified as fentanyl induced cough. All patients were received Propofol (2mg/kg) for induction of anaesthesia. Results: The mean age was 46.42±8.92 years. Incidence of fentanyl induced cough was observed in 4.3% cases and huffing manoeuvre was effective in 95.7% cases. Conclusion: Huffing manoeuvre is an effecting method of reducing fentanyl induced cough in patients undergoing surgery, especially the manoeuvre prevents developing of severe fentanyl induced cough. Keywords: Fentanyl, Cough, Huffing manoeuvre, Analgesic opioids
AO/OTA 31A2 and 31A3 Intertrochanteric Fractures Managed by Proximal Femoral Nail Antirotation (PFNA)
Authors: Tunio Zamir Hussain , Jhatiyal Rizwan Ali , Azeem Akhund Muhammad , Abbasi M. Kashif , Ali S. Muhammad , Jokhio M. Faraz
Published: November 2021

Aim: To study the clinical and radiological outcome of unstable intertrochanteric fracture AO/OTA 31A2, 31A3 fixed by proximal femoral nail antirotation Study design: Descriptive cross sectional study. Place and duration of study: Department of Orthopedic Surgery and Traumatology, Pir Abdul Qadir Shah Jilani Institute of Medical Sciences, Gambat, Sindh from 1st January 2016 to 31st December 2019. Methodology: Forty four cases having intertrochanteric fracture AO/OTA 31A2, 31A3 with age ranging from 18 year to 55 year of either gender were selected; patients having close fracture, who were willing were included in the study, while patients older than 55 year and younger than 18 year, AO/OTA 31A1 fracture, open fracture, bilateral injuries, smoker, alcoholic, drug addicted, poly-trauma, pathological fracture and history of poor compliance, psychiatric disease were excluded. Results: There were 26(59.09%) males and 18(40.91%) females with mean age was 41.3±7.7 years. Regarding classification; AO/OTA 31A2 were 33 (75%), and 31A3 were 11 (25%). Mean time for union was 18.5±3.55 weeks. The average time of follow-up was 48.5±6.6 weeks. Harris Hip Score was excellent (90-100) in 31(70.45%), good (80-89) in 7(15.91%), fair (70-80) in 3 (6.81%) and poor (<70) in 3 (6.81%). Conclusion: Intramedullary device proximal femoral nail antirotation can be labelled as implant of choice for unstable intertrochanteric fractures AO/OTA 31A2, 31A3, with fruitful clinical and radiological outcomes, and with fewer complications. Hip Harris score was excellent-good in 86% of the patients. Key words: Proximal femoral nail antirotation (PFNA), AO/OTA 31A2, 31A3, Intertrochanteric, unstable fracture
Histological Effects of Cotton seed Oil on Ovaries and RTWI among Female Albino Rats: RCT
Authors: Zahir Munazza , Ali Khan Ghazazfar , Aslam Summera , Sarosh Arva , Shahzad Muhammad , Laique Talha
Published: November 2021

Background: Concerns over the rising infertility rate among humans is now becoming a global health issue. Aim: To observe the histological changes in ovaries while measuring relative tissue weight indices of all ovaries among different groups receiving cottonseed oil. Study Design: Randomized controlled trial. Methodology: Twenty four adult female albino rats (12 weeks of age) were divided into 04 groups. Group-1 (Control) rats were given orally distilled water @ 400mg (equivalent to 400μl)/kg body weight per day. Group-2, Group-3 & Group-4 rats were given cottonseed oil (treatment groups) @ 400mg (equivalent to 432μl)/kg body weight per day, respectively, for a period of 30 days. Results: Cottonseed oil significantly reduced fertility in terms of follicles and ova in all treatment groups than control having non-significant differences among means of different groups. Conclusion: This study concluded that the crude cottonseed oil significantly affected female rat fertility in terms of reduced number of follicles and ova as shown histologically. However, it did not affect relative tissue weight indices among different groups. Hence, its use in edible products may result in increased women infertility. Keywords: Cottonseed Oil, Relative Tissue Weight Indices and Number of Follicles.
Efficacy of Combination Therapy Sofosbuvir, Daclatasvir and Ribavirin in Patients of Hepatitis C
Authors: Abdul Quddus Muhammad , Zaib Jahangir , Munawar Rukhsana , Tahir Rabia , Saeed Kiani Rizwan
Published: November 2021

Aim: To determine the effectiveness of antiviral drugs such as sofosbuvir, daclatasvir and ribavirin in hepatitis C patients and frequency of complications associated to antiviral therapy. Study Design: Prospective study. Place and Duration: This study was conducted at the department of Gastroenterology and General Medicine AK CMH / Sheikh Khalifa bin Zaid Al Nahyan Hospital Rawalakot Azad Kashmir for one year duration from 5th July 2020 to 5th July 2021. Methodology: 150 patients of both genders presented with hepatitis C were included. Patient’s ages were ranging from 25 to 70 years. After taking informed consent from all the patients, detailed medical history including age, sex, residence and education were recorded. Quantitative PCR test was obtained before starting the antiviral therapy, kit method was used. Treatment response was examined after completion of therapy. All the statistical data was analyzed by SPSS 24.0. Results: 88 (58.67%) patients were males while 62 (41.33%) patients were females. Mean age of patients was 48.52±9.38 years. At the end of treatment, 132 (88%) patients were cured and 15 (10%) patients were not cured, 3 (2%) patients had lost to follow-up. Complications associated to therapy were noted as anemia, ascites, hepatic encephalopathy and liver cirrhosis in 40 (26.67%), 20 (13.33%), 7 (4.67%) and 6 (4%) patients respectively. Conclusion: Combination antiviral therapy with Sofosbuvir, daclatasvir and ribavirin shows better results in patients with Hepatitis C with 88% cure rate. Anemia was the most frequent complication found at end of therapy. Keywords: Hepatitis C, Sofosbuvir, Daclatasvir, Ribavirin
EVALUASI PELAKSANAAN KURIKULUM 2013 DALAM MATA PELAJARAN PENDIDIKAN AGAMA BUDDHA DAN BUDIPEKERTI
Authors: Sadtyadi Hesti
Published: November 2021

Penelitian ini bertujuan untuk mengetahui bagaimana proses, dan output dalam penerapan kurikulum 2013 pendidikan agama Buddha pada pendidikan dasar dan menengah. Penelitian ini merupakan penelitian evaluasi, dengan model evaluasi program CIPP. Hasil dari penelitian ini menunjukkan bahwa proses pendidikan agama Buddha pada pendidikan dasar dan menengah, dalam penerapan kurikulum 2013, telah berjalan cukup baik. Output pendidikan agama Buddha dan Budi pekerti, pada tingkat dasar dan menengah, dalam penerapan kurikulum 2013, telah memiliki kuantitas capaian tujuan (output) pembelajaran ketercapaian nilai yang baik. Semua siswa dalam belajar berhasil dengan baik. Kualitas capaian tujuan (product), dilihat tentang perkembangan kondisi sikap dan minat siswa terhadap mata pelajaran, juga kemampuan siswa dalam menerapkan dan praktik beragama dalam kesehariannya. Siswa telah bersikap positif.
REPRESENTASI TUTURAN DIREKTIF DALAM TERJEMAHAN KITAB DHAMMAPADA BAB PAPA VAGGA
Authors: Purnomo Danang Try
Published: November 2021

Tulisan ini mendeskripsikan penggunaan tindak tutur ilokusi direktif yang terkandung dalam kitab Dhammapada. Data tulisan ini diperoleh dari sumber kepustakaan, yakni kitab Dhammapada bagian Papa Vagga yang bertemakan „kejahatan.‟ Dari hasil analisis data diperoleh bahwa tindak tutur direktif „teguran‟ dan „nasihat‟ adalah tindak tutur paling banyak digunakan dalam merealisasikan pesan kebenaran ajaran keagamaan. Sementara itu, jenis tindak tutur lain ditemukan adalah „larangan,‟ „ajakan,‟ dan „permintaan.‟ Perbedaan kuantitas penggunaan tindak tutur tersebut merepresentasikan fenomena alami dari peristiwa tutur sesuai dengan tujuan dan konteks sosialnya, yakni menyampaikan ajaran sesuai dengan permasalahn yang dibicarakan.
PENERAPAN PEMBELAJARAN QUANTUM TEACHING PADA MATERI AKU DAN LINGKUNGANKU DALAM PENDIDIKAN AGAMA BUDDHA UNTUK MENINGKATKAN KEAKTIFAN DAN PEMAHAMAN KONSEP MATERI SISWA KELAS XI SMK MPU TANTULAR BANYUMAS
Authors: Sutrisno  , Hariyanto  , Hatmono Prihadi Dwi
Published: November 2021

Keaktifan siswa dan pemahaman konsep terhadap materi menjadi kendala bagi siswa kelas XI SMK Mpu Tantular Banyumas. Permasalahan ini disebabkan oleh pembelajaran yang diterapkan masih monoton. Tujuan penelitian ini yaitu untuk mengetahui penerapan pembelajaran Quantum Teaching dapat meningkatkan keaktifan dan pemahaman konsep siswa kelas XI SMK Mpu Tantular Banyumas pada materi “aku dan lingkunganku”. Penelitian ini merupakan penelitian tindakan kelas model Kurt Lewin. Instrumen yang digunakan berupa lembar observasi, pedoman wawancara, tes pemahaman konsep. Data kuantitatif dianalisis dengan deskriptif komparatif dan data kualitatif dianalisis dengan teknik analisis kritis. Hasil penelitian menunjukkan nilai rata-rata keaktifan siswa meningkat dari 43,2; siklus pertama menjadi 56; dan siklus kedua menjadi 79,74. Nilai rata-rata pemahaman konsep materi meningkat dari 64,46; siklus pertama menjadi 75,56; dan siklus kedua menjadi 84,46. Berdasarkan hasil penelitian, disimpulkan bahwa penerapan pembelajaran Quantum Teaching meningkatkan keaktifan siswa. Pemahaman konsep siswa meningkat dalam memahami konsep-konsep materi ajar.
Baremos en español del Mini-SEA (Mini Social Cognition and Emotional Assessment) en adultos normales de Buenos Aires
Authors: Clarens María Florencia
Published: November 2021

Introducción y objetivos: El Mini SEA es una evaluación cognitiva rápida para estudiar la cognición social. Consiste en una versión de la Prueba de Faux Pas y una prueba de reconocimiento emocional. El objetivo del trabajo fue obtener los primeros valores normativos del Mini SEA de habla hispana. Material y métodos: Se reclutaron 64 voluntarios sanos que fueron evaluados con el Mini SEA por neuropsicólogos especializados de dos centros especializados en Buenos Aires. Resultados: La media (M) total fue de 25+/- 4. La M del Score del Faux Pas fue de 12,5+/- 2,4 y del Score  del Reconocimiento Emocional fue 12,8+/- 1,5. Se dividió la muestra en 4 grupos etarios: Grupo 1 (<50 años), Grupo 2 (50-59 años), Grupo 3 (60-69 años) y Grupo 4 (mas de 70 años). Se hallaron diferencias en el continuo de la edad en el puntaje del Reconocimiento Emocional entre el grupo 1 y 4 (p<0,05) y entre el grupo 3 y el 4 (p<0,01) no así en la prueba modificada del Faux Pas. Conclusión: Este estudio presenta los primeros valores normativos del Mini SEA para una población de habla hispana. Es una prueba rápida y fácil y permite estudiar la cognición social de forma adecuada y precisa sobretodo en estadios prodrómicos de enfermedades neurodegenerativas.
Pelatihan Manajemen Kelompok Masyarakat bagi Petani Ikan Nila di Desa Paya Udang Kecamatan Seruwai Kabupaten Aceh Tamiang
Authors: Navia Zidni Ilman , Maulizar Sandri , Ramaidani Ramaidani , Aini Milfa , Rahayuni Sri , Mahyuda Sindi , Andika Ridho Maulana
Published: November 2021

Paya Udang merupakan salah satu desa yang terletak di kecamatan Seruway kabupaten Aceh Tamiang, Propinsi Aceh. Karena kurangnya pemahaman terkait manajemen kelompok masyarakat dalam penglolaan budidaya ikan air tawar di desa Paya Udang maka perlu dilakukan pelatihan menajemen kelompok. Tujuan dari kegiatan pelatiahan ini adalah untuk membantu masyarakat desa Paya Udang dalam membentuk kelompok budidaya ikan air tawar di desa Paya Udang dan untuk meningkatkan kesadaran masyarakat di desa Paya Udang pentingnya membentuk usaha dengan melibatkan kelompok. Kegiatan ini dilakukan di desa Paya Udang, Kecamtan Seruway, Kabupaten Aceh Tamiang dengan melibatkan 20 orang peserta. Metode yang digunakan berupa pendekatan Participatory Rural Appraisal (PRA) dan Community development. Hasil dalam kegiatan pelatihan ini adalah terbentuknya kelompok budidaya ikan nila di desa Paya Udang Kecamatan Seruwai Kabupaten Aceh Tamiang yang dikoordinir langsung oleh ketua BUMK desa.
Edupreneurship Pembuatan Kue dan Roti dengan Metode 4 Langkah untuk Memanfaatkan Pangan Potensi Lokal bagi Santri Pondok Pesantren Salafiyah Sulus Salam Balikpapan
Authors: Farida Farida , Winnarko Henry , Nugroho Tri Retno , Dwiningrum Nawang Retno
Published: November 2021

Pondok pesantren Salafiyah Subulus Salam merupakan pesantren yang tetap mempertahankan sistim pembelajaran tradisonal/salaf dan merupakan pondok tahfiz qur’an yang menghasilkan lulusan penghafal penghafal Al qur’an handal. Namun tidak hanya pengetahuan dan ketaqwaan yang harus dimiliki untuk dapat bersaing di dunia nyata setelah lulus sekolah, namun tentunya memiliki pengetahuan, kemampuan dan keterampilan (skill) yang lain juga tidak kalah pentingnya. Dengan memberikan edupreneurship dan pelatihan, selain memberikan semangat entrepreneur juga dibekali dengan kemampuan dan keterampilan (skill) yang nantinya akan membantu kelangsungan hidup setelah lulus sekolah, tidak hanya melakukan dakwah, namun dapat juga berwirausaha dengan kemampuan dan keterampilan yang dimiliki. Tujuan dilaksanakan pengabdian kepada masyarakat bagi santri pondok pesantren Salafiyah Subulus Salam untuk memberikan edupreneurship kepada santriwati pondok pesantren memberikan pengetahuan tentang enterpreneurship untuk membangkitkan semangat wirausaha juga dibekali kemampuan, keterampilan dengan memberikan pelatihan dan memanfaatkan potensi lokal yang mudah didapatkan dengan harga relative murah dan terjangkau, yang ada di kota Balikpapan. Pada pelaksanaan pengabdian masyarakat ini lebih di titik beratkan pada pembuatan kue dan roti dengan menggunakan kangkung sebagai bahan tambahan pada pembuatan kue dan roti dan pada pengolahannya menggunakan peralatan yang sederhana disesuaikan dengan kondisi pondok pesantren. Dengan diberikannya edupreneurship dan pelatihan dapat membangkitkan semangat wirausaha bagi santri pondok pesantren Subulus Salam.
Perkütan vertebroplasti uygulanan postmenopozal hastalarda osteoporoza eşlik eden sistemik hastalıklar
Authors: Özger Özkan , Kaplan Necati
Published: November 2021

Amaç: Vertebroplasti ilk kez 1984 yılında vertebra hemanjiomu olan bir hastada uygulanmıştır. Ortalama yaşam süresinin artması osteoporoz olgu sayısındaki artışa paralel olarak vertebral çökme kırıklarının görülme sıklığını da artmıştır. Pediküllerden vertebra gövdesine polimetilmetakrilat (PMMA) enjeksiyonunu içeren minimal invaziv bir tekniktir. Bu çalışmada perkütan vertebroplasti (PVP) uygulanan vertebra kompresyon kırığı (VKK) olan postmenopozal osteoporozlu (PMO) hastalarda eşlik eden hastalıklar ve bu hastalıkların sıklıkları değerlendirildi. Gereç ve Yöntem: Nöroşirürji kliniğimizde Mayıs 2015-Mayıs 2019 tarihleri arasında PVP uygulanan VKK olan PMO’lu 69 kadın hasta retrospektif olarak gözden geçirildi. Hastaların demografik verileri ile birlikte eşlik eden sistemik hastalıkları hasta dosyalarından kaydedildi. Bulgular: Çalışmamıza dahil edilen hastaların yaş ortalamaları 73,30 ± 9.09 (49-92 yıl) yıldı. Hipertansiyon, eşlik eden sistemik hastalıklar arasında %39,1’lik oranıyla ilk sırada yer aldı. Sonra azalan sırayla osteoartrit (OA), tip II diyabetes mellitus (DM), gastrointesitinal sistem hastalıkları, kardiyak hastalıklar, serebrovasküler hastalıklar, Alzheimer hastalığı, kronik obstruktif akciğer hastalığı (KOAH), geçirilmiş spinal cerrahi, tiroid hastalıkları, anemi, kronik böbrek yetmezliği (KBY), epilepsi, sigara, glokom, malignite ve depresyon saptandı. Özgeçmişinde özellik olmayan hasta sayısı ise %13’tü. Sonuç: Ülkemizde ve tüm dünyada özellikle yaşlı popülasyonda sık görülen PMO’un sistemik hastalıklar ve bazı cerrahi müdahalelerle şiddeti artabilir veya tedavisi bozulabilir. Osteoporozdan ve eşlik eden sistemik hastalıklardan korunmak cerrahi girişim uygulamaktan daha önemlidir.
Pornography and Speech Act Theory – An In-Depth Survey
Authors: Dombrovszki Áron
Published: November 2021

Considering the short history of the feminist philosophy of language, Rae Langton’s article “Speech Acts and Unspeakable Acts” was highly influential as one of the first positive research programs in the movement. In her paper, Langton – using John L. Austin’s speech act theory – interprets Catharine MacKinnon’s thesis: pornography is a speech that subordinates and silences women. Despite the importance of the subject, those unfamiliar with certain historical and contextual features of the topic would hardly understand it.

My paper aims to introduce some of the major accounts in this special area at the intersection of speech act theory and feminist philosophy. Rather than just reconstructing Langton’s arguments and the most common objections against it, I take a more holistic approach, examining its surrounding literature as well.

My article has six sections. In Section 1, I contrast the conservative and liberal arguments against pornography and sketch MacKinnon’s liberal critique. In Section 2, I give alternative interpretations of MacKinnon’s thesis that “pornography is harm.” In Section 3, I try to make sense of the prima facie implausible assumption that pornography is speech. In Section 4 and 5, I analyze the Langtonian theories about subordination and silencing. Finally, in Section 6, I mention the most challenging problems for Langton’s approach, considering the verbal nature of pornography, the limits of the protection of free speech, and the different positions on sexual consent.
Slurs Subordinate by Cueing the Ideology
Authors: Prien Bernd
Published: November 2021

In recent years, a number of authors (e.g., Rae Langton, Mary K. McGowan, and Ishani Maitra) have tried to understand sexist and racist hate speech using John Austin’s speech act theory. These authors agree that acts of hate speech subordinate in two senses: on the one hand, they cause subordination insofar as they have subordinating causal consequences. On the other hand, they also constitute subordination insofar as the speech acts themselves, i.e. independently of their causal consequences, subordinate in some sense. However, there is disagreement about how exactly subordination in this latter sense is to be understood.

My proposal builds on and refines that of Rebecca Kukla. Following Kukla, I assume that central cases of hate speech are, regarding the type of speech act, interpellations or vocatives, and that slurs are interpellations with a certain kind of content. An interpellation is a speech act of hailing another person, using a social role or identity she has, such as “Hi, Eli!” or “Officer, …”. Slurs are speech acts of the same type, however, with a derogated, subordinated social role as their content. I adopt Kukla’s general theory of speech acts to analyze interpellations. According to this theory, speech acts strive to change the normative commitments and entitlements of others. I argue that in the case of interpellations, this normative output is best understood as a call on the addressee to activate an identity or a social role she already has, according to the ideology, but which she may not be actively playing at the moment. I argue that no special authority is required to make such a call.

I then propose an explanation of the sense in which slurs constitute subordination. Applying the analysis of interpellations, we can see that slurs call upon the addressee to actively play a derogated social role she has according to the ideology. In this sense, slurs can be said to cue the ideology, to use Swanson’s suggestive phrase.
„Elmélet vs. gyakorlat” a performativitás felől. Adalékok a praxis-vitához
Authors: Kicsák Lóránt
Published: November 2021

Az Elpis folyóirat hasábjain kibontakozó praxis-vitához hozzászólni megtisztelő, komoly feladat. Olvasva az egyre szerteágazóbb diskurzust, úgy döntöttem, hozzászólásomban visszakanyarodom az „eredeti” kérdéshez, és elmélet és gyakorlat viszonyát egy másik perspektívába helyezem.

Egyetértek Rosta Kosztasszal abban, hogy „ez a vita csak akkor folytatható le produktív módon, ha résztvevői vagy metafilozófiai vagy más irányzatokat ki nem rekesztő attitűdöt vesznek fel”. Azonban nem értem, miért lenne irreleváns, ki, mit gondol a filozófiáról. Persze nem lényegmeghatározását kell adnunk, már csak azért sem, mert a filozófiára szintén érvényes az, ami az emberre: „essentiája az existentiájában rejlik”. Főleg nem lehet irreleváns a kérdés, amikor a filozofálás sajátosságain és lehetőségein – korántsem változatlan, hanem mindenkor történetileg is meghatározott lehetőségfeltételein – kell elgondolkodnunk. Mert szerintem Nemes vitairata erre ösztönöz, nem pedig arra, amit írásának címe („Filozófiai tudás vs. filozofálás”) sugall, mintha csak egyetlen tétje lenne: választani a filozófia elméleti vagy gyakorlati művelése között. Én inkább azt a szándékot olvasom ki belőle, hogy nyissunk meg egy tágas teret, melyben fesztelenül feltehető egy fajsúlyos kérdés: mivégre filozofálunk? Ehhez mérten, miként filozofálunk, ami közvetlenül befolyásolja, hogy mi történik a filozofálásban.
Incidence of Research Gap Years in Orthopaedic Residency Applicants: The New Standard?
Authors: Cotter Eric J. , Polce Evan M. , Lee Eric , Williams Kathryn L. , Spiker Andrea M. , Grogan Brian F. , Lang Gerald J.
Published: November 2021

Introduction:

The purpose of this study was to (1) determine the incidence of a research gap year (RGY) in orthopaedic residency applicants at a single institution over a seven-year span; (2) compare applicant characteristics between applicants who did a RGY with those who did not, and (3) report variables associated with match success for RGY applicants.

Methods:

Applicants who reported taking a year out from medical school to pursue research on their Electronic Residency Application Service to a single institution from 2014 to 2015 through 2020 to 2021 were reviewed.

Results:

A strong positive correlation was noted between the percentage of applicants who participated in a RGY and time (Pearson correlation: r = 0.945 [95% confidence interval (CI), 0.666­0.992], P = 0.001). Over the study period, 11% of applicants had done a RGY, most commonly after their third year of medical school (82.7%). Most RGY applicants matched orthopaedics (72.8%) and 19.4% matched at the same institution they did their RGY.

Conclusion:

The percentage of RGY applicants to the study institution nearly doubled between 2014 to 2015 and 2020 to 2021. RGY applicants had a higher match rate than nationally published match rates. Further study is needed on a national level.
Tinjauan Etis Kristen Terhadap Kebebasan Beragama Di Lingkungan Sekolah Negeri Dengan Dicabutnya SKB Tiga Menteri
Authors: Surna Suriawan , Widodo Priyantoro
Published: November 2021

In order to protect the equal right to freedom of thought, belief and religion of all students in all public schools in Indonesia; in February 2021, the central government represented by three ministers, namely Minister of Education and Culture, Home Affairs Minister, and Religious Affairs Minister issued Joint Ministerial Decree (SKB) on the Use of Uniforms and Attributes for Students, Educators, and Education Personnel in state schools at the primary and secondary level .On 3 May 2021, the Supreme Court of the Republic of Indonesia revoked it. The purpose of this paper is to state a universal Christian ethical attitude in the midst of national and state life which is based on Pancasila and Bhineka Tunggal Ika (“Unity in Diversity”), especially in response to the revocation of the 3 Ministerial Decree that used to guarantee and protect religious freedom in state schools. The method used in this paper is phenomenological-qualitative research. The result is hoped to become a consideration for the central government and every child of the nation in general, and especially for followers of the Lord Jesus Christ in the land of Pancasila, Indonesia.Keywords: freedom of religion, Christian ethics, universal AbstrakDemi menjaga kebebasan dalam mengekspresikan keyakinan yang dianut semua siswa di semua sekolah negeri di Indonesia, maka pemerintah pusat yang diwakili tiga Menteri yaitu Menteri Pendidikan dan Kebudayaan, Menteri Dalam Negeri, dan Menteri Agama mengeluarkan Surat Keputusan Bersama (SKB). Penggunaan Pakaian Seragam dan Atribut bagi Peserta Didik, Pendidik, dan Tenaga Kependidikan di Lingkungan Sekolah yang diselenggarakan Pemda pada Jenjang Pendidikan Dasar dan Menengah pada bulan Februari 2021. Namun SKB tiga Menteri tersebut terkesan mengekang dan membatasi tradisi atau budaya masyarakat yang sudah lama ada di daerah di Indonesia. Pada tanggal 3 Mei 2021, Mahkamah Agung Republik Indonesia mencabut SKB 3 Menteri tersebut. Tujuan dari makalah ini adalah untuk menyatakan sikap etis Kristen di tengah-tengah kehidupan berbangsa dan bernegara yang berdasarkan Pancasila dan Bhineka Tunggal Ika dalam menyikapi ketiadaan SKB 3 Menteri yang menjamin dan melindungi kebebasan beragama di lingkungan sekolah negeri. Metode yang digunakan di dalam makalah ini adalah metode penelitian fenomenologi-kualitatif. Hasilnya diharapkan menjadi pertimbangan bagi pemerintah pusat dan setiap anak bangsa pada umumnya serta khususnya bagi pengikut Tuhan Yesus Kristus di bumi Pancasila, Indonesia.Kata Kunci: Kebebasan Beragama, Etika Kristen
NCCN Guidelines® Insights: B-Cell Lymphomas, Version 5.2021
Authors: Zelenetz Andrew D. , Gordon Leo I. , Chang Julie E. , Christian Beth , Abramson Jeremy S. , Advani Ranjana H. , Bartlett Nancy L. , Budde L. Elizabeth , Caimi Paolo F. , De Vos Sven , Dholaria Bhagirathbhai , Fakhri Bita , Fayad Luis E. , Glenn Martha J. , Habermann Thomas M. , Hernandez-Ilizaliturri Francisco , Hsi Eric , Hu Boyu , Kaminski Mark S. , Kelsey Christopher R. , Khan Nadia , Krivacic Susan , LaCasce Ann S. , Lim Megan , Narkhede Mayur , Rabinovitch Rachel , Ramakrishnan Praveen , Reid Erin , Roberts Kenneth B. , Saeed Hayder , Smith Stephen D. , Svoboda Jakub , Swinnen Lode J. , Tuscano Joseph , Vose Julie M. , Dwyer Mary A. , Sundar Hema
Published: November 2021

In the last decade, a better understanding of the molecular pathogenesis of B-cell non-Hodgkin lymphomas has resulted in the development of novel targeted therapies, such as small molecule inhibitors of select kinases in the B-cell receptor pathway, antibody–drug conjugates, and small molecules that target a variety of proteins (eg, CD-19, EZH2, and XPO-1–mediated nuclear export). Anti-CD19 CAR T-cell therapy, first approved for relapsed/refractory (R/R) diffuse large B-cell lymphoma, has also emerged as a novel treatment option for R/R follicular lymphoma and mantle cell lymphoma. These NCCN Guideline Insights highlight the new targeted therapy options included in the NCCN Guidelines for B-Cell Lymphomas for the treatment of R/R disease.
Germline PALB2 Variants and PARP Inhibitors in Endometrial Cancer
Authors: Cilento Michael A. , Poplawski Nicola K. , Paramasivam Sellvakumaram , Thomas David M. , Kichenadasse Ganessan
Published: November 2021

PARP inhibitors are orally administered antineoplastic agents that affect the homologous recombination (HR) repair pathway, and are approved by the FDA for the treatment of ovarian, breast, pancreatic, and prostate cancers. This report presents a case of recurrent endometrial carcinoma occurring in a woman with a germline pathogenic PALB2 whole-exon deletion. This uncommon finding in a patient with endometrial carcinoma provided the opportunity to use a management strategy of PARP inhibition with olaparib, resulting in a prolonged response to treatment; however, disease progression eventually occurred. Further studies are required to elucidate the mechanisms underlying resistance to PARP inhibition, and the potential future treatment options in this setting. Current recommendations for risk management of female carriers of PALB2 variants focus on breast and ovarian cancer risk. This case raises the additional question of a potential role for risk-reducing hysterectomy in female carriers of PALB2 variants.
Coleccionismo y patrocinio de arte en el siglo XVII: el ejemplo de la familia Muñoz de Otálora
Authors: Martínez Martínez José Antonio
Published: November 2021

En este artículo se intenta explicar el coleccionismo y el patrocinio de arte y bibliográfico en el siglo XVII a través del ejemplo que nos proporcionan los inventarios de bienes del licenciado Alonso Muñoz de Otálora, alcalde de casa y corte, y de Juana Clara Muñoz de Otálora. El coleccionismo desde el punto de vista social se presenta como un símbolo del estatus y como una manifestación del prestigio social de los individuos y de las instituciones. La casa, como espacio físico y residencial, albergar las colecciones artísticas y otros objetos y joyas que nos acercan al nivel de vida y al lujo de las familias de poder del siglo XVII. Finalmente, el patrocinio y financiación de iglesias y ermitas se presentan como signo inequívoco de la magnificencia de la familia y como una manifestación de su poder y compromiso social con los valores civilizatorios.

This article tries to explain the collecting and sponsorship of art and bibliography in the seventeenth century through the example provided by the inventories of assets of the lawyer Alonso Muñoz de Otálora, mayor of the house and court, and Juana Clara Muñoz de Otálora . Collecting from the social point of view is presented as a symbol of status and as a manifestation of the social prestige of individuals and institutions. The house, as a physical and residential space, the houses, the artistic collections and other objects and jewels that bring us closer to the standard of living and the luxury of the 17th century that power families. Finally, the sponsorship and financing of churches and hermitages are presented as an unequivocal sign of the magnificence of the family and as a manifestation of its power and social commitment to civilized values.
Los lugares de memoria como patrimonio: propuesta de itinerarios en Cartagena durante la II República (1931-1936)
Authors: Egea Ibarra Carmen
Published: November 2021

Este trabajo tiene como fin elaborar una guía de itinerarios históricos de la ciudad de Cartagena durante los años de la II República. Se pretende preservar un patrimonio inmaterial, aquellos lugares de la memoria de la ciudad republicana que hacen referencia a los símbolos de identidad de una colectividad. A sus monumentos silenciosos y silenciados. El objetivo es recuperar el contexto histórico de los edificios y calles y destacar su importancia didáctica, memorialista y cultural, teniendo en cuenta la Ley de Memoria Histórica.

El estudio se organiza en tres capítulos: el primero aborda el contexto histórico, Cartagena en los años 30; el segundo titulado Ciudad y Memoria, donde se analiza la estructura de la ciudad siguiendo a Kevin Lynch. El último capítulo desarrolla tres rutas: la política, destacando el Arsenal y el Ayuntamiento; la cultural con el Ateneo y la Universidad Popular y por último la ruta carcelaria con el viejo Penal, el Castillo de San Julián y la Cárcel de San Antón.
don de la siesta
Authors: Sánchez de la Peña Víctor
Published: November 2021

Miguel Ángel Hernández aborda la siesta como una resistencia en lo cotidiano. Incluyendo teoría, literatura, arte y autobiografía (pues el autor se nos presenta como un buen practicante de estas siestas), nos vemos sumergidos en un mapa de referencias sobre el sesteo que son miradas desde la situación actual de crisis sanitaria. Su escritura tiene la capacidad de, alguna forma, bajar a nuestros contextos, creando en el lector una sensación de común, de lazos culturales y vínculos sociales marcados por la necesidad de volver a pensar desde este momento de descanso colectivo (aunque cada uno lo practique en su casa) tras el mediodía. En esta reseña nos centraremos especialmente en su forma de entrelazar este ejercicio de memoria en primera persona con referencias artísticas y teóricas, siendo coherente con un formato de escritura basado en anotaciones mucho más horizontales y abiertas que una investigación rigurosamente acotada.

Miguel Ángel Hernández approaches the nap as a resistance in the everyday. Including theory, literature, art and autobiography (as the author presents himself as a good practitioner of these naps), we are immersed in a map of references on napping that are looked at from the current health crisis situation. His writing has the capacity to come down to our contexts, creating in the reader a sense of commonality, of cultural ties and social links marked by the need to rethink from this moment of collective rest (even if each one practices it at home) after midday. In this review we will focus especially on his way of interweaving this exercise of first-person memory with artistic and theoretical references, being coherent with a writing format based on annotations that are much more horizontal and open than a rigorously bounded investigation.