bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and Synthesis of Oligosaccharides that Interfere with Glycoprotein Quality‐control systems
Authors: Arai Midori A. , Matsuo Ichiro , Hagihara Shinya , Totani Kiichiro , Maruyama Jun‐ichi , Kitamoto Katsuhiko , Ito Yukishige
Published: November 2005

Calnexin (CNX) and its soluble homologue calreticulin (CRT) are lectin‐like molecular chaperones that help newly synthesized glycoproteins to fold correctly in the rough endoplasmic reticulum (ER). To investigate the mechanism of glycoprotein‐quality control, we have synthesized structurally defined high‐mannose‐type oligosaccharides related to this system. This paper describes the synthesis of the non‐natural undecasaccharide 2 and heptasaccharide 16, designed as potential inhibitors of the ER quality‐control system. Each possesses the key tetrasaccharide element (Glc1Man3) critical for the CNX/CRT binding, while lacking the pentamannosyl branch required for glucosidase II recognition. These oligosaccharides were evaluated for their ability to bind CRT by isothermal titration calorimetry (ITC). As expected, each of them had a significant affinity towards CRT. In addition, these compounds were shown to be resistant to glucosidase II digestion. Their activities in blocking the chaperone function of CRT were next measured by using malate dehydrogenase (MDH) as a substrate. Their inhibitory effects were shown to correlate well with their CRT‐binding affinities, both being critically dependent upon the presence of the terminal glucose (Glc) residue.
Fluorescent Detection of Apoptotic Cells by Using Zinc Coordination Complexes with a Selective Affinity for Membrane Surfaces Enriched with Phosphatidylserine
Authors: Hanshaw Roger G. , Lakshmi C. , Lambert Timothy N. , Johnson James R. , Smith Bradley D.
Published: November 2005

The appearance of phosphatidylserine on the membrane surface of apoptotic cells (Jurkat, CHO, HeLa) is monitored by using a family of bis(Zn2+‐2,2′‐dipicolylamine) coordination compounds with appended fluorescein or biotin groups as reporter elements. The phosphatidylserine affinity group is also conjugated directly to a CdSe/CdS quantum dot to produce a probe suitable for prolonged observation without photobleaching. Apoptosis can be detected under a wide variety of conditions, including variations in temperature, incubation time, and binding media. Binding of each probe appears to be restricted to the cell membrane exterior, because no staining of organelles or internal membranes is observed.
Synthesis and Properties of Aminopropyl Nucleic Acids
Authors: Zhou Ding , Lagoja Irene M. , Rozenski Jef , Busson Roger , Van Aerschot Arthur , Herdewijn Piet
Published: November 2005

Oligonucleotides that contain up to three aminopropyl nucleoside analogues have been synthesized. Dimers of aminopropyl adenine and thymidine were prepared and used as building blocks by applying phosphoramidite chemistry. Both R and S isomers of the aminopropyl nucleosides were used. This incorporation led to a reduction of thermal stability of double‐stranded DNA. Furthermore, the (R)‐adenine analogue, which yielded (S)‐APNA, can be considered as a candidate for universal base pairing.
LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis
Authors: Mayer Almuth , Taguchi Takaaki , Linnenbrink Anton , Hofmann Carsten , Luzhetskyy Andriy , Bechthold Andreas
Published: November 2005

LanV is involved in the biosynthesis of landomycin A. The exact function of this enzyme was elucidated with combinatorial biosynthesis by using Streptomyces fradiae mutants that produce urdamycin A. After expression of lanV in S. fradiae ΔurdM, which is a mutant that accumulates rabelomycin, urdamycinon B and urdamycin B were found to be produced by the strain. This result indicates that LanV is involved in the 6‐ketoreduction of the angucycline core, which preceeds a 5,6‐dehydration reaction. 9‐C‐D‐Olivosyltetrangulol was also produced by this strain; this demonstrates that LanV catalyses the aromatization of ring A of the angucycline structure. Coexpression of lanV and lanGT2 in S. fradiae AO, a mutant that lacks all four urdamycin glycosyltransferases, resulted in the production of tetrangulol and the glycoside landomycin H, both of which have an aromatic ring A. As glycosylated angucyclines were not observed after expression of lanGT2 in the absence of lanV, we conclude that LanGT2 needs an aromatized ring A for substrate recognition.
Reversible Sequential‐Binding Probe Receptor–Ligand Interactions in Single Cells
Authors: Schreiter Christoph , Gjoni Marinela , Hovius Ruud , Martinez Karen L. , Segura Jean‐Manuel , Vogel Horst
Published: November 2005

With the reversible sequential (ReSeq) binding assay,we present a novel approach for the ultrasensitive profiling of receptor function in single living cells. This assay is based on the repetitive application of fluorescent ligands that have fast association–dissociation kinetics. We chose the nicotinic‐acetylcholine receptor (nAChR) as a prototypical example and performed ReSeq equilibrium, kinetic, and competition‐binding assays using fluorescent derivatives of the antagonist α‐conotoxin GI (α‐CnTx). Thereby, we determined the binding constants of unlabeled α‐CnTx and d‐tubocurarine. The high selectivity of α‐CnTx for muscle‐type nAChR made it possible to observe specific binding even in the presence of other nAChR subtypes. Imaging of individual nAChRs and ligand‐binding cycles to single cells in microfluidic devices demonstrated the ultimate miniaturization and accuracy of ReSeq‐binding assays even at low receptor‐expression levels. We expect our approach to be of generic importance for functional screening of compounds or membrane receptors, and for the detailed characterization of rare primary cells.
Acyl Transfer in Clorobiocin Biosynthesis: Involvement of Several Proteins in the Transfer of the Pyrrole‐2‐carboxyl Moiety to the Deoxysugar
Authors: Freitag Anja , Wemakor Emmanuel , Li Shu‐Ming , Heide Lutz
Published: November 2005

Clorobiocin is an aminocoumarin antibiotic containing a pyrrole‐2‐carboxyl moiety, attached through an ester bond to a deoxysugar. The pyrrole moiety is important for the binding of the antibiotic to its biological target, gyrase. The complete biosynthetic gene cluster for clorobiocin has been cloned and sequenced from the natural producer, Streptomyces roseochromogenes DS 12.976. In this study, the genes cloN1 and cloN7 were deleted separately from a cosmid containing the complete clorobiocin cluster. The modified cosmids were introduced into the genome of the heterologous host Streptomyces coelicolor M512 by using the integration functions of the ΦC31 phage. While a heterologous producer strain harbouring the intact clorobiocin biosynthetic gene cluster accumulated clorobiocin, the cloN1‐ and cloN7‐defective integration mutants accumulated a clorobiocin derivative that lacked the pyrrole‐2‐carboxyl moiety, while also producing free pyrrole‐2‐carboxylic acid. The structures of these metabolites were confirmed by NMR and MS analysis. These results showed that CloN1 and CloN7, together with the previously investigated CloN2, are involved in the transfer of the pyrrole‐2‐carboxyl moiety to the deoxysugar of clorobiocin. A possible mechanism for the role of these three proteins in the acyl‐transfer process is suggested.
Use of Short Duplexes for the Analysis of the Sequence‐Dependent Cleavage of DNA by a Chemical Nuclease, a Manganese Porphyrin
Authors: Mourgues Sophie , Kupan Adam , Pratviel Geneviève , Meunier Bernard
Published: November 2005

A manganese porphyrin, manganese(III)‐bis(aqua)‐meso‐tetrakis(4‐N‐methylpyridiniumyl)porphyrin, in the presence of KHSO5 is able to perform deoxyribose or guanine oxidation depending on its mode of interaction with DNA. These two reactions involve an oxygen‐atom transfer or an electron transfer, respectively. The oxidative reactivity of the manganese‐oxo porphyrin was compared on short oligonucleotide duplexes of different sequences. The major mechanism of DNA damage is due to deoxyribose hydroxylation at a site of strong interaction, an (A⋅T)3 sequence. Guanine oxidation by electron transfer was found not to be competitive with this major mechanism. It was found that a single intrastrand guanine was three orders of magnitude less reactive than an (A⋅T)3 sequence. The reactivity of a 5′‐GG sequence was found to be intermediate and was estimated to be two orders of magnitude less than that of an (A⋅T)3 site. Short oligonucleotide duplexes, as double‐stranded‐DNA models, proved to be convenient tools for the study of the comparative reactivity of this reagent toward different sequences of DNA. However, they showed a particular reactivity at their terminal base pairs (the “end effect”) that biased their modeling capacity for double‐helix‐DNA models.
Impact of a lead glass screen on scatter radiation to eyes and hands in interventional cardiologists
Authors: Maeder Micha , Brunner‐La Rocca Hans Peter , Wolber Thomas , Ammann Peter , Roelli Hans , Rohner Franziska , Rickli Hans
Published: November 2005

The objective of this study was to assess the impact of a transparent lead glass screen (TLGS) on scatter radiation to the eyes and the hands in interventional cardiologists and to compare the results to the recommended annual threshold values of 150 and 500 mSv, respectively. Local radiation doses to the left eye and the ring finger of the left hand of three operators (A, B, C) were assessed by thermoluminiscence dosimeters during 813 coronary angiographies (CAs), including 190 ad hoc percutaneous coronary interventions (PCIs) either with a TLGS placed between patient and operator [615 CAs including 138 ad hoc PCIs; dose‐area product (DAP) = 84.9 ± 71.3 Gy·cm2], or without (198 CAs including 52 PCIs; DAP = 85.7 ± 61.5 Gy·cm2). To determine the efficacy of the TLGS, average DAP‐normalized local doses were calculated. Using a TLGS, operator A, B, and C performed 259 (in 9 months), 211 (in 8 months), and 145 CAs (in 8 months) with TLGS and acquired cumulative eye lens doses of 5.5, 1.5, and 1.0 mSv corresponding to extrapolated annual doses of 7.3, 2.3, and 1.5 mSv. The cumulative finger doses were 9.6, 10.3, and 6.4 mSv, resulting in extrapolated annual doses of 12.8, 15.5, and 9.6 mSv. Compared to 139 (in 5 months), 36 (in 2 months), and 23 CAs (in 2 months) without TLGS, the use of a TLGS reduced the DAP‐normalized eye dose by a factor of 19 (with TLGS 0.153 vs. without TLGS 2.924 μSv/Gy·cm2), whereas only a weak effect on the dose to the hands was observed (with TLGS 0.504 vs. without TLGS 0.578 μSv/Gy·cm2). The consequent use of a TLGS efficiently reduces scatter radiation to the operator's eyes in daily practice, but has only minimal effects on the dose to the hands. © 2005 Wiley‐Liss, Inc.
Template Refolding by Use of an Antibody‐Coupled Affinity Column
Authors: Katoh S. , Kumada Y. , Maeshima N.
Published: November 2005

To improve the efficiency and throughput, the biointeraction between an antigen and antibody was used for refolding in a packed column, in which an antibody against carbonic anhydrase coupled on a gel support was used as a template ligand. A denatured solution of CAB was mixed with a refolding buffer in a mixing chamber, and was supplied to the antibody‐coupled column for refolding. Higher refolding efficiencies were obtained in the column than by the batch dilution method at relatively low concentrations of denaturant. By increasing the adsorption capacity of the column, the efficiency of refolding, as well as the throughput, could be increased.
Evaluation of the Langmuir Formalism for Modeling the Adsorption Isotherms of Proteins and Polyelectrolytes in Simulations of Ion Exchange Chromatography
Authors: Jozwik M. , Kaczmarski K. , Freitag R.
Published: November 2005

The adsorption behavior of two cationic proteins (cytochrome c and α‐chymotrypsinogen) and one synthetic polycation (poly(diallylmethylammonium chloride), polyDADMAC) was investigated on a porous particle based and a monolithic cation exchanger column. All isotherms could be fitted to the Langmuir equation. Subsequently, the derived Langmuir equation parameters were combined with two kinetic models, the transport dispersive (TD) and the lumped pore diffusion (POR) models, to simulate breakthrough curves of the substances on the ion exchanger columns. In the case of the proteins, simulations based on the experimentally derived Langmuir parameters showed poor correlation with the experimental breakthrough curves. When the Langmuir parameters were instead fitted in the simulations, adequate agreement could be achieved. In the case of the TD model, the overall mass transfer parameter had to also be fitted as a function of the protein concentration to optimize the fit. In the case of the POR model, one set of transport parameters could be used to simulate the breakthrough curves independent of the mobile phase composition (buffer concentration 75 or 120 mM, NaCl concentration 0–5 %) or the protein concentration (0.001–0.3 mg/mL). As in the TD model, it was not possible to use the experimentally derived Langmuir parameters to simulate the breakthrough curves with the POR model. Instead, the Langmuir parameters had to be fitted for each individual case in order to achieve agreement. Neither the TD nor the POR model could satisfactorily simulate the behavior of the synthetic polyelectrolyte. The Langmuir equation can thus be used to provide standard transport models with an adsorption formalism to simulate breakthrough curves in ion exchange chromatography. However, the existence of a close correlation of the actually observed physico‐chemical adsorption behavior of the involved proteins could not be supported.
Chromatography Based Purification of rhGM‐CSF from Recombinant Rice Cell Culture
Authors: Hwang S. Y. , Lee E. K. , Terashima M.
Published: November 2005

Plant cells are increasingly used as alternative host organisms for recombinant protein production requiring post‐translational modifications because they have relatively low risks of hazardous viral contamination compared to animal cells. On the other hand, the plant cell culture route has intrinsic disadvantages, including a relatively low expression titer and difficulties in the purification. We developed a simple and scalable, chromatography based process to purify rhGM‐CSF from recombinant rice cell culture. It consisted of cell removal by microfiltration, ammonium sulfate precipitation, anion exchange chromatography, and SEC‐HPLC. α‐Amylase, used as a leader sequence in the expression vector, was the major impurity protein co‐purified with rhGM‐CSF. The purification process resulted in a final purity of ca. 95 % (as verified by size exclusion chromatography) and an overall recovery yield of ca. 48 % from the culture broth (as verified by ELISA).
Simulated Moving Bed Operation for Size Exclusion Plasmid Purification
Authors: Paredes G. , Makart S. , Stadler J. , Mazzotti M.
Published: November 2005

Interest in producing large amounts of plasmid DNA (pDNA) has increased in the last decade as a result of the advances made in gene therapy and DNA vaccines. The last stage of the manufacturing process involves a purification scheme guaranteeing a safe and stable product, considering the authorities' recommendations. This work studies the first step of the purification scheme, i.e., a group separation step based on size exclusion chromatography and using the simulated moving bed technology (SMB). The cleaning in place, crucial for the process validation, is implemented into the SMB in the so‐called CIP‐SMB configuration. Experiments were designed using the simple approach of triangle theory. The feed consisted of a clarified cleared lysate. The results indicate that total recovery of pDNA is possible and that the productivity can be tuned considering the trade‐off with purity. Detailed simulations were used to validate these results after a cleared lysate model was established.
Protein Mass Transfer Kinetics in Ion Exchange Media: Measurements and Interpretations
Authors: Carta G. , Ubiera A. R. , Pabst T. M.
Published: November 2005

The paper gives a summary of successful methods for measuring protein mass transfer kinetics in ion exchange matrices along with models needed to interpret experimental results. Both macroscopic methods (isocratic elution, gradient elution, batch adsorption, frontal analysis) and microscopic methods are considered. In all cases the main focus is the determination of the effective intraparticle diffusivity in order to permit a comparison of different stationary phases and provide a basis for predicting chromatographic process performance. Experimental results for representative systems are evaluated alongside the experimental and modeling aspects. Practical criteria for the selection of experimental conditions and the application of different models are discussed along with the advantages and disadvantages of the various approaches.
Optimization of SMB Technology Working as a Single Column System
Authors: Pötschacher P.
Published: November 2005

The scope of this work was the design, installation, testing and optimization of a pilot plant for simulated moving bed (SMB) chromatography applying the single column technology (ESMB). The working volume of the resin used as the adsorbent changes during loading and regeneration. Resin breathing leads to poor separation performance. In a single packed bed column simultaneous expansion and contraction of the resin bed equalize each other, which leads to a better separation performance. In order to reach industrial targets the SMB unit is optimized by the adaptation of several process parameters. During optimization the behavior of the system with regards to concentration profile and pressure is examined. Other feedback parameters are the purity and yield of the withdrawn liquids. A working diagram is used for the prediction and explanation of the behavior of the process. The standard triangle diagram has been adapted to the particularities of the process.
Preparative Gradient Chromatography
Authors: Seidel‐Morgenstern A.
Published: November 2005

During a chromatographic separation, it is convenient to keep the essential operating parameters like temperature, pressure, mobile phase flow‐rate, and mobile phase composition constant. Though, it is well known that in contrast to this isocratic operation the intelligent modulation of certain operating parameters can improve the separation performance significantly. Such gradient approaches are widely applied in analytical (linear) chromatography to reduce the time of analysis and to enhance the selectivity. In contrast, the extent of application of these gradients is still rather limited in the field of preparative (nonlinear) chromatography. The first part of this paper is devoted to the discussion of the principal differences between linear and nonlinear and isocratic and gradient chromatography. The second part focuses on introducing a countercurrent process that allows separation in a continuous manner, efficiently exploiting a two‐step solvent composition gradient.
Industrial Scale cGMP Purification of Pharmaceutical Grade Plasmid‐DNA
Authors: Urthaler J. , Buchinger W. , Necina R.
Published: November 2005

The advances in gene therapy and genetic vaccination based on plasmid DNA result in an increasing demand of pharmaceutical grade plasmids produced under cGMP. A generic process consisting of a cell disintegration step followed by three different chromatography steps has been developed. Cell lysis is performed by an automated continuous reactor. The clarified lysate is further purified by hydrophobic interaction, anion exchange, size exclusion chromatography and by an ultra‐filtration step. The produced plasmid DNA was up to 98 % in the supercoiled form. The final genomic DNA content was lower than 10 μg/mg plasmid DNA, RNA was not detectable by agarose gel electrophoresis, the protein content was lower than 1 μg/mg plasmid DNA and the endotoxin content lower than 0.1 EU/mg plasmid DNA. An overall yield of 50 % and higher in the desired final buffer could be obtained. This process is scalable and does not require animal derived materials, detergents or organic solvents, meeting current standards for therapeutic applications.
Properties and Characterization of High Capacity Resins for Biochromatography
Authors: Müller E.
Published: November 2005

At the moment ion exchanger resins display the highest binding capacities for proteins. Polymeric surface modification methods utilize the full pore space and allow to guarantee high capacities for small as well as for large proteins. Capacity maximization is also possible by pore size optimization fitting the pore size to the molecule size without loosing a lot of dynamic binding capacity under current process conditions. Further improvements of resins can be achieved by optimizing the pore structure and pore volume, which could enhance the mass transfer and so the dynamic binding capacity.
Aspects of Modeling a Preparative Ion‐Exchange Step for Antibody Purification
Authors: Nilsson B.
Published: November 2005

In protein chromatography large molecules have to diffuse into the stationary phase. The molecular sizes of the proteins make the diffusion rates low or very low and the separation can be assumed to be mass transfer limited. In this study three different prepacked columns, with different bead sizes, are used for the separation of IgG and BSA to confirm or reject this assumption in an ion‐exchange application. The separations are modeled and calibrated against gradient elution data. Model calibration of reaction‐dispersive, transport‐dispersive and general rate model structures are discussed and the analysis shows that the columns are best modeled by different model structures, because different behaviors are rate‐limiting. Experiments can be described surprisingly well by reaction‐dispersive model structures, especially for BSA. Broad elution peaks for IgG indicate mass transfer limitations. Calibration of models capturing diffusive effects shows that the pore diffusion coefficients are much higher than expected, compared with the literature, indicating that there are other forces dominating the mass transport in the beads.
Shallow Bed Adsorption: Theoretical Background and Applications
Authors: Hahn R. , Tscheliessnig A. , Zöchling A. , Jungbauer A.
Published: November 2005

The estimation of parameters for the design of chromatography columns at extremely small scale is required when the amount of feed stock or gel material is limited. The method of shallow bed adsorption, also known as zero length column or differential contactor allows the estimation of uptake kinetics and equilibria, at a scale of less than 100 μL bed volume. The shallow bed is an infinite bath, which assumes that the liquid phase concentration does not change during the process of adsorption. This is achieved by keeping the volume of the stationary phase negligibly small so that the bound material does not influence the liquid phase concentration. Several examples are given to demonstrate the usefulness of this method and a protocol is suggested as to how it can be implemented in process development.
Preferred 3D‐Structure of Peptides Rich in a Severely Conformationally Restricted Cyclopropane Analogue of Phenylalanine
Authors: Crisma Marco , De Borggraeve Wim M. , Peggion Cristina , Formaggio Fernando , Royo Soledad , Jiménez Ana I. , Cativiela Carlos , Toniolo Claudio
Published: November 2005

Terminally blocked, homo‐peptide amides of (R,R)‐1‐amino‐2,3‐diphenylcyclopropane‐1‐carboxylic acid (c3diPhe), a chiral member of the family of Cα‐tetrasubstituted α‐amino acids, from the dimer to the tetramer, and diastereomeric co‐oligopeptides of (R,R)‐ or (S,S)‐c3diPhe with (S)‐alanine residues to the trimer level were prepared in solution and fully characterized. The synthetic effort was extended to terminally protected co‐oligopeptide esters to the hexamer, where c3diPhe residues are combined with achiral α‐aminoisobutyric acid residues. The preferred conformations of the peptides were assessed in solution by FT‐IR absorption, NMR, and CD techniques, and for seven oligomers in the crystal state (by X‐ray diffraction) as well. This study clearly indicates that c3diPhe, a sterically demanding cyclopropane analogue of phenylalanine, tends to fold peptides into β‐turn and 310‐helix conformations. However, when c3diPhe is in combination with other chiral residues, the conformation preferred by the resulting peptides is also dictated by the chiral sequence of the amino acid building blocks. The (S,S)‐enantiomer of this α‐amino acid, unusually lacking asymmetry in the main chain, strongly favors the left‐handedness of the turn/helical peptides formed.
Controlling Stereochemical Outcomes of Asymmetric Processes by Catalyst Remote Molecular Functionalizations: Chiral Diamino‐oligothiophenes (DATs) as Ligands in Asymmetric Catalysis
Authors: Albano Vincenzo Giulio , Bandini Marco , Barbarella Giovanna , Melucci Manuela , Monari Magda , Piccinelli Fabio , Tommasi Simona , Umani‐Ronchi Achille
Published: November 2005

The synthesis, characterization, and structure‐guided application of a new class of highly versatile chiral C2‐symmetric diamine‐oligothiophene ligands in Pd‐catalyzed asymmetric transformations are presented. Experimental investigations of the intimate role of pendant π‐conjugate oligothiophenes in determining the catalytic activity of the corresponding chiral Pd complexes are described. Their unusual behavior opens up new routes toward the logical design of finely tuned organometallic catalysts by remote structural functionalizations.
Development of a Ligand Knowledge Base, Part 1: Computational Descriptors for Phosphorus Donor Ligands
Authors: Fey Natalie , Tsipis Athanassios C. , Harris Stephanie E. , Harvey Jeremy N. , Orpen A. Guy , Mansson Ralph A.
Published: November 2005

A prototype collection of knowledge on ligands in metal complexes, termed a ligand knowledge base (LKB), has been developed. This contribution describes the design of DFT‐calculated descriptors for monodentate phosphorus(III) donor ligands in a range of representative complexes. Using the resulting data, a ligand space is mapped and predictive models are derived for metal complexes. Important characteristics, including chemical, computational and statistical robustness for the generation and exploitation of such an LKB are described. Chemical robustness ensures transferability of the descriptors, as well as comprehensive sampling of ligand space. To make the calculations amenable to automation in an e‐science setting, a reliable, well‐defined computational approach has been sought from which the descriptors can be readily extracted. The LKB has been explored with multivariate statistical methods. Principal component analysis (PCA) is used for the mapping of chemical space, projecting multiple descriptors into scatter plots which illustrate the clustering of chemically similar ligands. Interpretation of the resulting principal components in terms of established steric and electronic properties and the importance of its statistical robustness to variations in the ligand set are discussed. Multiple linear regression (MLR) models have been derived, demonstrating the versatility of the descriptors for modeling varied experimentally determined parameters (bond lengths, reaction enthalpies and bond‐stretching frequencies). The importance of re‐sampling methods for testing the robustness of predictions is highlighted. A strategy for the construction of a robust LKB suitable for the modeling of ligand and complex behavior is outlined based on these observations.
M5H5X (M: Ag, Au, Pd, Pt; X: Si, Ge, P, S): Hydrometal Pentagons with D5h Planar Pentacoordinate Nonmetal Centers.
Authors: Li Si‐Dian , Miao Chang‐Qing
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Infrared Spectrum and Structure of the Hf(OH)4 Molecule.
Authors: Wang Xuefeng , Andrews Lester
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Novel Corrugated In9 Anionic Layer in Li2Y5In9: Square Pyramidal In5 Clusters Interconnected by Unusual Butterfly In4 Clusters.
Authors: Sun Zhong‐Ming , Mao Jiang‐Gao , Pan Da‐Chun
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Investigation of the Crystal Structure and the Structural and Magnetic Properties of SrCu2(PO4)2.
Authors: Belik Alexei A. , et al. et al.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
The Indium Subnitrides M6In4(InxLiy)N3‐z (M: Sr and Ba).
Authors: Bailey Mark S. , Shen Daniel Y. , McGuire Michael A. , Fredrickson Daniel C. , Toby Brian H. , DiSalvo Francis J. , Yamane Hisanori , Sasaki Shinya , Shimada Masahiko
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
High Resolution Diffraction Studies with Synchrotron Radiation on the Structure of Li0.95Mn2.05O4 Spinel.
Authors: Nowicki W. , Darul J. , Piszora P. , Baehtz C. , Wolska E.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synchrotron X‐Ray Powder Diffraction Studies on the Order—Disorder Phase Transition in Lithium Ferrites.
Authors: Darul J. , Nowicki W. , Piszora P. , Baehtz C. , Wolska E.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Spectral Similarity of Bridging and Nonbridging Oxygen in Tellurites.
Authors: Hart R. T. , Zwanziger J. W. , Werner‐Zwanziger U. , Yates J. R.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Polymorphic One‐Dimensional (N2H4)2ZnTe: Soluble Precursors for the Formation of Hexagonal or Cubic Zinc Telluride.
Authors: Mitzi David B.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Indium(I) Hexafluoropnictates (InPnF6; Pn: P, As, Sb).
Authors: Mazej Zoran
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of a Polyoxovanadate Cluster Representing a New Topology.
Authors: Khan M. Ishaque , Ayesh Samar , Doedens Robert J. , Yu Minghui , O'Connor Charles J.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Synthesis and Characterization of [PtIn6](GeO4)2O and Its Solid Solution [PtIn6] (GaO4)2‐x(GeO4)xOx/2 (0 ≤ x ≤ 2): Gradual Color Change of the Solid Solution from Black (x = 0) to Yellow (x = 2) as a Consequence of Quantum Dot Effect.
Authors: Koehler Juergen , Friedrich Holger , Whangbo Myung‐Hwan , Villesuzanne Antoine
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Lithiation—Substitution Sequences of Substituted Allylamines.
Authors: Kim Dwight D. , Lee Suk Joong , Beak Peter
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Enantioselective Alkynylation and Phenylation of Aromatic Aldehydes Promoted by Atropisomeric 1,1′‐Binaphthylazepine‐Based Amino Alcohols.
Authors: Pizzuti Maria Gabriella , Superchi Stefano
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Intramolecular [2 + 2 + 1] Cycloadditions with (Cyclobutadiene)tricarbonyliron.
Authors: Seigal Benjamin A. , An Mi Hyun , Snapper Marc L.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Aminomethylene Ketones and Enamines in Heterocyclic Synthesis: Synthesis of Functionally Substituted Pyridine, Pyrazole, Fused Pyrimidine and Fused [1,5]Diazocine Derivatives
Authors: Hassanien Abu Zeid A. , Mohamed Mona H. , Gohzlan Said A. S.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Atom Transfer Radical Additions with the Cationic Half‐Sandwich Complex [Cp*Ru(PPh3)2(CH3CN)]OTf.
Authors: Quebatte Laurent , Scopelliti Rosario , Severin Kay
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Heteropoly Blue as a Reaction‐Controlled Phase‐Transfer Catalyst for the Epoxidation of Olefins.
Authors: Mingqiang Li , Xigao Jian
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Selective Monofluorination of Diols Using DFMBA.
Authors: Yoneda Atsushi , Fukuhara Tsuyoshi , Hara Shoji
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Regioselective Thiocyanation of Aromatic and Heteroaromatic Compounds Using Ammonium Thiocyanate and Oxone.
Authors: Wu Guaili , Liu Qiang , Shen Yinglin , Wu Wentao , Wu Longmin
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Mn(III)‐Based C—C Bond Formation: Regioselective α′‐Allylation of Various α,β‐Unsaturated, α‐ and β‐Alkoxy α,β‐Unsaturated Ketones.
Authors: Tanyeli Cihangir , Oezdemirhan Devrim
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
A Straightforward Synthesis of Ynones by Reaction of Dimethylalkynylaluminum Reagents with Acid Chlorides.
Authors: Wang Baomin , Bonin Martine , Micouin Laurent
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
An Efficient Dehydrohalogenation Method for the Synthesis of α,β,β‐Trifluorostyrenes, α‐Chloro‐β,β‐difluorostyrenes and E‐1‐Arylperfluoroalkenes.
Authors: Anilkumar R. , Burton Donald J.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
N‐Acyl‐2‐phenyliminooxazolidines as Chemoselective Monoacylating Agents.
Authors: Jang Jung Hee , Kim Hyung Jin , Kim Jae Nyoung , Kim Taek Hyeon
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Highly Stereoselective Aldol Reaction Based on Titanium Enolates from (S)‐1‐Benzyloxy‐2‐methyl‐3‐pentanone.
Authors: Solsona Joan G. , Nebot Joaquim , Romea Pedro , Urpi Felix
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Diastereoselective Intermolecular Pauson—Khand Reactions of Chiral Cyclopropenes.
Authors: Pallerla Mahesh K. , Fox Joseph M.
Published: November 2005

For Abstract see ChemInform Abstract in Full Text.
Asymmetric Synthesis of Cyclopropanes from Lithiated Aryloxiranes and α,β‐Unsaturated Fischer Carbene Complexes.
Authors: Capriati Vito , Florio Saverio , Luisi Renzo , Perna Filippo Maria , Barluenga Jose
Published: November 2005

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Alternative, Easy Preparation of (Diacetoxyiodo)arenes from Iodoarenes Using Potassium Peroxodisulfate as the Oxidant.
Authors: Hossain Md. Delwar , Kitamura Tsugio
Published: November 2005

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Ultrasonically Activated Reduction of Substituted Nitrobenzenes to Corresponding N‐Arylhydroxylamines.
Authors: Ung Stephane , Falguieres Annie , Guy Alain , Ferroud Clotilde
Published: November 2005

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New Selective O‐Debenzylation of Phenol with Mg/MeOH.
Authors: Huang Wei , Zhang Xu , Liu Hong , Shen Jianhua , Jiang Hualiang
Published: November 2005

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Kinetic Resolution of Alcohols Using a 1,2‐Dihydroimidazo[1,2‐a]quinoline Enantioselective Acylation Catalyst.
Authors: Birman Vladimir B. , Jiang Hui
Published: November 2005

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The Synthesis and Application of Fluorous Boronates Without Perfluorinated Solvents.
Authors: Wang Chun‐Yan , Meng Wei‐Dong , Huang Yan‐Gen , Qing Feng‐Ling
Published: November 2005

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Formation of Oxiranes During the Preparation of Aroylacetonitriles.
Authors: Toche R. B. , Jachak M. N. , Badgujar N. S. , Avhale A. B. , Kendre D. B.
Published: November 2005

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An Anionic Nucleophilic Catalyst System for the Diastereoselective Synthesis of trans‐β‐Lactams.
Authors: Weatherwax Anthony , Abraham Ciby J. , Lectka Thomas
Published: November 2005

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Tuning the Reactivity and Chemoselectivity of Electron‐Poor Pyrroles as Dienophiles in Cycloadditions with Electron‐Rich Dienes.
Authors: Chretien Antony , Chataigner Isabelle , Piettre Serge R.
Published: November 2005

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Modular Synthesis of Chiral Homo‐ and Heterotrisoxazolines. Improving the Enantioselectivity in the Asymmetric Michael Addition of Indole to Benzylidene Malonate.
Authors: Ye Meng‐Chun , Li Bin , Zhou Jian , Sun Xiu‐Li , Tang Yong
Published: November 2005

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Synthesis and the Reactions of Trifluoromethylated 1,2,3‐Triketones 2‐(Het)arylhydrazones and 4,7‐Dihydroazolo[5,1‐c]triazines.
Authors: Khudina O. G. , Shchegol'kov E. V. , Burgart Ya. V. , Kodess M. I. , Kazheva O. N. , Chekhlov A. N. , Shilov G. V. , Dyachenko O. A. , Saloutin V. I. , Chupakhin O. N.
Published: November 2005

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Efficient and Eco‐Friendly Process for the Synthesis of N‐Substituted 4‐Methylene‐2‐oxazolidinones in Ionic Liquids.
Authors: Zhang Qinghua , Shi Feng , Gu Yanlong , Yang Jing , Deng Youquan
Published: November 2005

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Synthesis of Some New Substituted Ethanone Hydrazones Containing 1H‐1,2,4‐Triazole and Thiazole.
Authors: Sun Ya‐Dong , Liu Fang‐Ming , Xie Zheng‐Feng
Published: November 2005

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Improved Synthesis of Irbesartan, an Antihypertensive Active Pharmaceutical Ingredient
Authors: Satyanarayana Bollikonda , Sumalatha Yasareni , Venkatraman Sundram , Reddy Ghanta Mahesh , Reddy Padi Pratap
Published: November 2005

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Synthesis and NMR Spectroscopic Characterization of Some Fluoro‐2H‐1‐benzopyran Derivatives.
Authors: Teral Yannick , Roubaud Gabriel , Aubert Claude , Faure Robert , Campredon Mylene
Published: November 2005

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A Convenient One‐Pot Synthesis of Fentanyl.
Authors: Gupta Pradeep Kumar , Ganesan Kumaran , Pande Ambuja , Malhotra Ramesh Chandra
Published: November 2005

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Metalation of Biginelli Compounds. A General Unprecedented Route to C‐6 Functionalized 4‐Aryl‐3,4‐dihydropyrimidinones.
Authors: Singh Kamaljit , Singh Sukhdeep , Mahajan Aman
Published: November 2005

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A Rapid and Efficient Method for the Reduction of Quinoxalines.
Authors: McKinney Andrew M. , Jackson Kevin R. , Salvatore Ralph Nicholas , Savrides Elena‐Maria , Edattel Mary Jane , Gavin Terrence
Published: November 2005

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Asymmetric Synthesis of 1‐Substituted Tetrahydro‐3‐benzoazepines.
Authors: Wirt Ursula , Froehlich Roland , Wuensch Bernhard
Published: November 2005

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Champanones, Yellow Pigments from the Seeds of Champa (Campomanesia lineatifolia).
Authors: Bonilla Adriana , Duque Carmenza , Garzon Cristina , Takaishi Yoshihisa , Yamaguchi Kazutaka , Hara Noriyuki , Fujimoto Yoshinori
Published: November 2005

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Synthesis of 9α‐Chloro‐ and Bromo‐androstane Derivatives.
Authors: Reyes Mayra , Alvarez Yoanna M. , Fuente Ariadna , Ruiz Jose A. , Velez‐Castro Herman
Published: November 2005

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Investigation into Direct Use of Protected 3,4‐Dehydropyroglutamates in Synthesis.
Authors: Moody Claire M. , Young Douglas W.
Published: November 2005

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Asymmetric Hydrogenation of N‐Sulfonylated‐α‐dehydroamino Acids: Toward the Synthesis of an Anthrax Lethal Factor Inhibitor.
Authors: Shultz C. Scott , Dreher Spencer D. , Ikemoto Norihiro , Williams J. Michael , Grabowski Edward J. J. , Krska Shane W. , Sun Yongkui , Dormer Peter G. , DiMichele Lisa
Published: November 2005

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Unusual Dimethyl Ketal from Cycloadduct of 4,6‐O‐Benzylidene‐D‐allal and Dichloroketene.
Authors: Chun Keun Ho , Yoon Taemoon , Shin Jeoung E Nam , Jo Choonsil , Jo Yun Ju , Yun Hoseop , Oh Jonghoon
Published: November 2005

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Isolation and Synthesis of a Novel β‐Carboline Guanidine Derivative Tiruchanduramine from the Indian Ascidian Synoicum macroglossum
Authors: Ravinder K. , Reddy A. Vijender , Krishnaiah P. , Ramesh P. , Ramakrishna S. , Laatsch H. , Venkateswarlu Y.
Published: November 2005

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Rapid Synthesis of the N‐Methylwelwitindolinone Skeleton.
Authors: MacKay James A. , Bishop Raynauld L. , Rawal Viresh H.
Published: November 2005

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An Efficient Two‐Step Synthesis of Jensenone Isolated from Eucalyptus jensenii. Synthesis of Analogues and Evaluation as Antioxidants.
Authors: Bharate Sandip B. , Chauthe Siddheshwar K. , Bhutani Kamlesh K. , Singh Inder P.
Published: November 2005

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Conversion of Zinc Oxide Nanobelts into Superlattice‐Structured Nanohelices.
Authors: Gao Pu Xian , Ding Yong , Mai Wenjie , Hughes William L. , Lao Changshi , Wang Zhong Lin
Published: November 2005

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Synthesis of Multi‐Walled and Bamboo‐Like Well‐Crystalline CNx Nanotubes with Controllable Nitrogen Concentration (x = 0.05‐1.02).
Authors: Xiong Yujie , Li Zhengquan , Guo Qixun , Xie Yi
Published: November 2005

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Synthesis and Characterization of Mn2P2S6 Single‐Crystal Nanorods and Nanotubes.
Authors: Li Chunhui , Wang Xun , Peng Qing , Li Yadong
Published: November 2005

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Chemical Control of Charge Transfer and Recombination at Semiconductor Photoelectrode Surfaces
Authors: Lewis Nathan S.
Published: November 2005

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Selenium/Zeolite Y Nanocomposites
Authors: Goldbach Andreas , Saboungi Marie‐Louise
Published: November 2005

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Chemistry of Halfmetallic and Related Cation‐Ordered Double Perovskites
Authors: Karppinen M. , Yamauchi H.
Published: November 2005

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Open‐Framework Aluminophosphates: Synthesis, Characterization and Transition Metal Modifications
Authors: Rajic Nevenka
Published: November 2005

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Inorganic Nitrenium Ions: Formation, Structure, and Reactivity in the Gas Phase
Authors: Grandinetti Felice
Published: November 2005

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Structures and Electromagnetic Properties of the A‐site Ordered Perovskite Manganite
Authors: Ueda Y. , Nakajima T.
Published: November 2005

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Conical Cavitands as Second Coordination Spheres and Protecting Environments. Toward Metal‐Centered, Intracavity Reactions
Authors: Armspach D. , Bagatin I. , Engeldinger E. , Jeunesse C. , Harrowfield J. , Lejeune M. , Matt D.
Published: November 2005

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Dynamic Behavior of Group 5 and 6 Transition Metal Complexes with NMR
Authors: Sakharov Sergei G.
Published: November 2005

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Conformational Mobility in Chelated Square‐Planar Rh, Ir, Pd, and Pt Complexes
Authors: Espinet Pablo , Casares Juan A.
Published: November 2005

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Palladium‐Catalyzed Reactions of Alcohols. Part D. Rearrangements, Carbonylations, Carboxylations, and Miscellaneous Reactions
Authors: Muzart Jacques
Published: November 2005

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The Structural Origins of Superior Performance in Sol—Gel Catalysts
Authors: Cirminna Rosaria , Ilharco Laura M. , Fidalgo Alexandra , Campestrini Sandro , Pagliaro Mario
Published: November 2005

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Some Recent Theoretical Advances in the Understanding of the Catalytic Activity of Au
Authors: Molina L. M. , Hammer B.
Published: November 2005

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Deviation from Physical Identity Between D‐ and L‐Tyrosine
Authors: Shinitzky Meir , Elitzur Avshalom C. , Deamer David W.
Published: November 2005

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η5‐Phosphinines
Authors: Streubel R.
Published: November 2005

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Lead Structures in Lithium Organic Chemistry
Authors: Stey Thomas , Stalke Dietmar
Published: November 2005

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Photophysics and Excited State Relaxation Dynamics of para‐Hydroxy‐ and para‐Amino‐Substituted Benzophenones
Authors: Palit Dipak K.
Published: November 2005

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Acid Catalysis in Fine Chemicals
Authors: Marx Emmanuel
Published: November 2005

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Rapid Screening of Cinchona Alkaloid Derived Phase‐Transfer Catalysts: Application in the Optimization of a Glycine Imine Alkylation
Authors: Lygo Barry , Andrews Benjamin I. , Hirst Jonathan D. , Melville James L. , Peterson Justine A. , Slack Daniel
Published: November 2005

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Dynamics of Adsorption of Cationic Surfactants at Air—Water and Solid—Liquid Interfaces
Authors: Atkin Rob , Eastoe Julian , Wanless Erica J. , Bain Colin D.
Published: November 2005

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Dynamics of Fast Reactions in Ionic Liquids
Authors: Funston Alison M. , Wishart James F.
Published: November 2005

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Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries
Authors: Zhao Jiang , Zhang Lu , Yan Bing
Published: November 2005

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Investigation of the Structure of 1‐Butyl‐3‐methylimidazolium Tetrafluoroborate and Its Interaction with Water by Homo‐ and Heteronuclear Overhauser Enhancement
Authors: Mele Andrea
Published: November 2005

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Asymmetric ring opening of terminal epoxides via kinetic resolution catalyzed by new bimetallic chiral (salen)Co complexes
Authors: Thakur Santosh Singh , Li Wen‐Ji , Shin Chang‐Kyo , Kim Geon‐Joong
Published: November 2005

The highly enantioselective hydrolytic kinetic resolution (HKR) of racemic terminal epoxides by new bimetallic chiral (salen)Co provides a operationally very simple protocol for the synthesis of enantiomerically enriched terminal epoxides (>99% ee) and diols. Optically pure chlorohydrins have been synthesized in one step by ring‐opening reactions of terminal epoxides with HCl using kinetic resolution. © 2005 Wiley‐Liss, Inc. Chirality
Secondary Synthesis of Two Cobalt Complexes by the Use of 5‐Sulfosalicylate and 1,10‐Phenanthroline and Their Crystal Structures
Authors: Fan Sai‐Rong , Zhu Long‐Guan
Published: November 2005

Cobalt(II) nitrate reacted with 1,10‐phenanthroline (phen) and 5‐sulfosalicylic acid (H3ssal) to yield the cobalt(II) complex [Co(phen)2(H2O)2](Hssal)·4H2O (1) and the reaction of 1 with copper acetate led to a novel complex [Co(phen)(H2O)4][Cu2(ssal)2(phen)2]·5H2O (2). These two complexes were cation‐anion species and the cationic motif [Co(phen)2(H2O)2]2+of 1 could be converted to [Co(phen)(H2O)4]2+ in the formation process of new anion [Cu2(phen)2(ssal)2]2− of 2. In both complexes abundant hydrogen bonds construct different supramolecular architectures, thus the conversion reaction can provide a new path to create novel supramolecular network.
Organic Nanotubes Prepared from Chiral Molecules by the Template Method
Authors: Zhao Li‐Yun , Yang Wen‐Sheng , Yang Zi‐Wen , Yao Jian‐Nian
Published: November 2005

Organic nanotubes from two kinds of chiral molecules, R‐di‐2‐naphthylprolinol (DNP) with an asymmetric carbon atom and R‐(+)‐1,1'‐bi‐2‐naphthol dimethyl ether (BNDE) with the conformational asymmetry, were prepared by the immersing technique using porous alumina membranes as the template. It was found that the nanotubes from DNP with an asymmetric carbon atom presented the same chirality as the solution with slight red shift of the CD signals upon the formation of the nanotubes, while no well‐defined chirality could be identified for the nanotubes from BNDE with the conformational asymmetry.