bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of Scyphozoan Venoms on Human Health and Current First Aid Options for Stings
Authors: Remigante Alessia , Costa Roberta , Morabito Rossana , La Spada Giuseppa , Marino Angela , Dossena Silvia
Published: March 2018

Cnidaria include the most venomous animals of the world. Among Cnidaria, Scyphozoa (true jellyfish) are ubiquitous, abundant, and often come into accidental contact with humans and, therefore, represent a threat for public health and safety. The venom of Scyphozoa is a complex mixture of bioactive substances—including thermolabile enzymes such as phospholipases, metalloproteinases, and, possibly, pore-forming proteins—and is only partially characterized. Scyphozoan stings may lead to local and systemic reactions via toxic and immunological mechanisms; some of these reactions may represent a medical emergency. However, the adoption of safe and efficacious first aid measures for jellyfish stings is hampered by the diffusion of folk remedies, anecdotal reports, and lack of consensus in the scientific literature. Species-specific differences may hinder the identification of treatments that work for all stings. However, rinsing the sting site with vinegar (5% acetic acid) and the application of heat (hot pack/immersion in hot water) or lidocaine appear to be substantiated by evidence. Controlled clinical trials or reliable models of envenomation are warranted to confirm the efficacy and safety of these approaches and identify possible species-specific exceptions. Knowledge of the precise composition of Scyphozoa venom may open the way to molecule-oriented therapies in the future.
A Study and Review of Effects of Botulinum Toxins on Mast Cell Dependent and Independent Pruritus
Authors: Ramachandran Roshni , Marino Marc , Paul Snighdha , Wang Zhenping , Mascarenhas Nicholas , Pellett Sabine , Johnson Eric , DiNardo Anna , Yaksh Tony
Published: March 2018

Pruriceptive itch originates following activation of peripheral sensory nerve terminals when pruritogens come in contact with the skin. The ability of botulinum neurotoxins (BoNTs) to attenuate transmitter release from afferent terminals provides a rationale for studying its effect on pruritus. This study investigated the effects of BoNT/A1 and BoNT/B1 on mast cell dependent (Compound 48/80:48/80) and independent (Chloroquine:CQ) scratching. C57Bl/6 male mice received intradermal injection of 1.5 U of BoNT/A1, BoNT/B1 or saline 2, 7, 14 and 21 days prior to ipsilateral 48/80 or CQ at the nape of the neck. Ipsilateral hind paw scratching was determined using an automated recording device. The effect of BoNTs on 48/80 mediated mast cell degranulation was analyzed in human and murine mast cells and the presence of SNAREs was determined using qPCR, immunostaining and Western blot. Pre-treatment with BoNT/A1 and BoNT/B1 reduced 48/80 and CQ induced scratching behavior starting on day 2 with reversal by day 21. Both serotypes inhibited 48/80 induced mast cell degranulation. qPCR and immunostaining detected SNAP-25 mRNA and protein, respectively, in mast cells, however, Western blots did not. This study demonstrates the long-lasting anti-pruritic effects of two BoNT serotypes, in a murine pruritus model using two different mechanistically driven pruritogens. These data also indicate that BoNTs may have a direct effect upon mast cell degranulation.
OTA Prevention and Detoxification by Actinobacterial Strains and Activated Carbon Fibers: Preliminary Results
Authors: El Khoury Rhoda , Choque Elodie , El Khoury Anthony , Snini Selma , Cairns Robbie , Andriantsiferana Caroline , Mathieu Florence
Published: March 2018

Ochratoxin A (OTA) is a mycotoxin produced by several species of Aspergillus and Penicillium that contaminate food and feed raw materials. To reduce OTA contamination, we first tested in vitro, actinobacterial strains as potential biocontrol agents and afterward, through a physical decontamination method using activated carbon fibers (ACFs). Actinobacterial strains were screened for their ability to reduce OTA in solid co-culture with A. carbonarius, which is the major OTA-producing species in European vineyards. Four strains showed a high affinity for removing OTA (67%–83%) with no significant effect on fungal growth (<20%). The mechanism of action was first studied by analyzing the expression of OTA cluster genes (acOTApks, acOTAnrps, acOTAhal) by RT-qPCR showing a drastic reduction in all genes (7–15 times). Second, the ability of these strains to degrade OTA was assessed in vitro on ISP2 solid medium supplemented with OTA (100 µg/L). Two strains reduced OTA to undetectable levels. As for the physical method, high adsorption rates were obtained for ACFs at 0.8 g/L with a 50% adsorption of OTA in red wine by AC15 and 52% in grape juice by AC20 within 24 h. These promising methods could be complementarily applied toward reducing OTA contamination in food chains, which promotes food safety and quality.
Scaling Properties of Spectra in New Exact Solutions of Rotating, Multi-Component Fireball Hydrodynamics
Authors: Csörgő Tamás , Kasza Gábor
Published: March 2018

We describe fireballs that rehadronize from a perfect fluid of quark matter, characterized by the lattice QCD equation of state, to a chemically frozen, multi-component mixture, that contains various kinds of observable hadrons. For simplicity and clarity, we apply a non-relativistic approximation to describe the kinematics of this expansion. Unexpectedly, we identify a secondary explosion that may characterize fireball hydrodynamics at the QCD critical point. After rehadronization, the multi-component mixture of hadrons keeps on rotating and expanding together, similarly to a single component fluid. After kinetic freeze-out, the effective temperature T i of the single-particle spectra of hadron type h i is found to be a sum of the kinetic freeze-out temperature T f (that is independent of the hadron type h i ) and a term proportional to the mass m i of hadron type h i . The coefficient of proportionality to m i is found to be independent of the hadron type h i but to be dependent on the radial flow and vorticity of collective dynamics.
Molecular Characterization of a Novel Species of Capillovirus from Japanese Apricot (Prunus mume)
Authors: Marais Armelle , Faure Chantal , Theil Sébastien , Candresse Thierry
Published: March 2018

With the increased use of high-throughput sequencing methods, new viruses infecting Prunus spp. are being discovered and characterized, especially in the family Betaflexiviridae. Double-stranded RNAs from symptomatic leaves of a Japanese apricot (Prunus mume) tree from Japan were purified and analyzed by Illumina sequencing. Blast comparisons of reconstructed contigs showed that the P. mume sample was infected by a putative novel virus with homologies to Cherry virus A (CVA) and to the newly described Currant virus A (CuVA), both members of genus Capillovirus. Completion of the genome showed the new agent to have a genomic organization typical of capilloviruses, with two overlapping open reading frames encoding a large replication-associated protein fused to the coat protein (CP), and a putative movement protein (MP). This virus shares only, respectively, 63.2% and 62.7% CP amino acid identity with the most closely related viruses, CVA and CuVA. Considering the species demarcation criteria in the family and phylogenetic analyses, this virus should be considered as representing a new viral species in the genus Capillovirus, for which the name of Mume virus A is proposed.
Constructing TC-1-GLUC-LMP2 Model Tumor Cells to Evaluate the Anti-Tumor Effects of LMP2-Related Vaccines
Authors: Sun Liying , Hao Yanzhe , Wang Zhan , Zeng Yi
Published: March 2018

Epstein-Barr virus (EBV) is related to a variety of malignant tumors, and its encoded protein, latent membrane protein 2 (LMP2), is an effective target antigen that is widely used to construct vector vaccines. However, the model cells carrying LMP2 have still not been established to assess the oncolytic effect of LMP2-related vaccines at present. In this study, TC-1-GLUC-LMP2 tumor cells were constructed as target cells to evaluate the anti-tumor effects of LMP2-assosiated vaccines. The results showed that both LMP2 and Gaussia luciferase (GLuc) genes could be detected by polymerase chain reaction (PCR) and reverse transcription-polymerase chain reaction (RT-PCR) in TC-1-GLUC-LMP2 cells. Western blot results showed that the LMP2 and Gaussia luciferase proteins were stably expressed in tumor cells for at least 30 generations. We mixed 5 × 104 LMP2-specific mouse splenic lymphocytes with 5 × 103 TC-1-GLUC-LMP2 target cells and found that the target cells were killed as the specific killing effect was obviously enhanced by the increased quantities of LMP2-peptide stimulated spleens. Furthermore, the tumor cells could not be observed in the mice inoculated TC-1-GLUC-LMP2 cells after being immunized with vaccine-LMP2, while the vaccine-NULL immunized mice showed that tumor volume gradually grew with increased inoculation time. These results indicated that the TC-1-GLUC-LMP2 cells stably expressing LMP2 and GLuc produced tumors in mice, and that the LMP2-specific cytotoxic T lymphocyte (CTL) effectively killed the cells in vitro and in vivo, suggesting that TC-1-GLUC-LMP2 cells can be used as model cells to assess the immune and antitumor effects of LMP2-related vaccines.
Human-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus
Authors: Burke Crystal , Froude Jeffrey , Miethe Sebastian , Hülseweh Birgit , Hust Michael , Glass Pamela
Published: March 2018

Western equine encephalitis virus (WEEV) causes symptoms in humans ranging from mild febrile illness to life-threatening encephalitis, and no human medical countermeasures are licensed. A previous study demonstrated that immune serum from vaccinated mice protected against lethal WEEV infection, suggesting the utility of antibodies for pre- and post-exposure treatment. Here, three neutralizing and one binding human-like monoclonal antibodies were evaluated against WEEV aerosol challenge. Dose-dependent protection was observed with two antibodies administered individually, ToR69-3A2 and ToR68-2C3. In vitro neutralization was not a critical factor for protection in this murine model, as ToR69-3A2 is a strong neutralizing antibody, and ToR68-2C3 is a non-neutralizing antibody. This result highlights the importance of both neutralizing and non-neutralizing antibodies in the protection of mice from WEEV lethality.
Harnessing the Power of T Cells: The Promising Hope for a Universal Influenza Vaccine
Authors: Clemens E. , Van de Sandt Carolien , Wong Sook , Wakim Linda , Valkenburg Sophie
Published: March 2018

Next-generation vaccines that utilize T cells could potentially overcome the limitations of current influenza vaccines that rely on antibodies to provide narrow subtype-specific protection and are prone to antigenic mismatch with circulating strains. Evidence from animal models shows that T cells can provide heterosubtypic protection and are crucial for immune control of influenza virus infections. This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. However, multiple hurdles exist for the realisation of a universal T cell vaccine. Overall primary concerns are: extrapolating human clinical studies, seeding durable effective T cell resident memory (Trm), population human leucocyte antigen (HLA) coverage, and the potential for T cell-mediated immune escape. Further comprehensive human clinical data is needed during natural infection to validate the protective role T cells play during infection in the absence of antibodies. Furthermore, fundamental questions still exist regarding the site, longevity and duration, quantity, and phenotype of T cells needed for optimal protection. Standardised experimental methods, and eventually simplified commercial assays, to assess peripheral influenza-specific T cell responses are needed for larger-scale clinical studies of T cells as a correlate of protection against influenza infection. The design and implementation of a T cell-inducing vaccine will require a consensus on the level of protection acceptable in the community, which may not provide sterilizing immunity but could protect the individual from severe disease, reduce the length of infection, and potentially reduce transmission in the community. Therefore, increasing the standard of care potentially offered by T cell vaccines should be considered in the context of pandemic preparedness and zoonotic infections, and in combination with improved antibody vaccine targeting methods. Current pandemic vaccine preparedness measures and ongoing clinical trials under-utilise T cell-inducing vaccines, reflecting the myriad questions that remain about how, when, where, and which T cells are needed to fight influenza virus infection. This review aims to bring together basic fundamentals of T cell biology with human clinical data, which need to be considered for the implementation of a universal vaccine against influenza that harnesses the power of T cells.
Educating the Future of Science and Medicine
Authors: Brown Mark
Published: March 2018

For the past two decades, veterinary educators have been at the forefront of innovations in educational practices related to science and medicine. Many of the resulting methods have been translated and implemented as best practices across the breadth of disciplines in higher education. However, past World Organization for Animal Health (OIE) global conferences have highlighted the necessity for improving global harmonization of veterinary medical education. This underscores a growing need for even broader dissemination of best practices and assessment programs related to educating our veterinary workforce.
Grain Size Distribution of Bedload Transport in a Glaciated Catchment (Baranowski Glacier, King George Island, Western Antarctica)
Authors: Sziło Joanna , Bialik Robert
Published: March 2018

The relationships among grain size distribution (GSD), water discharge, and GSD parameters are investigated to identify regularities in the evolution of two gravel-bed proglacial troughs: Fosa Creek and Siodło Creek. In addition, the potential application of certain parameters obtained from the GSD analysis for the assessment of the formation stage of both creeks is comprehensively discussed. To achieve these goals, River Bedload Traps (RBTs) were used to collect the bedload, and a sieving method for dry material was applied to obtain the GSDs. Statistical comparisons between both streams showed significant differences in flow velocity; however, the lack of significant differences in bedload transport clearly indicated that meteorological conditions are among the most important factors in the erosive process for this catchment. In particular, the instability of flow conditions during high water discharge resulted in an increase in the proportion of medium and coarse gravels. The poorly sorted fine and very fine gravels observed in Siodło Creek suggest that this trough is more susceptible to erosion and less stabilized than Fosa Creek. The results suggest that GSD analyses can be used to define the stage of development of riverbeds relative to that of other riverbeds in polar regions.
A Linear Programming Approach to Water Allocation during a Drought
Authors: Freire-González Jaume , Decker Christopher , Hall Jim
Published: March 2018

The economic impacts of a drought depend critically on how water is allocated to different users. Choices as to water allocation can often reflect wider economic policy, environmental, and social goals and constraints. This research applies a multi-objective linear programming input-output method to determine a suite of water supply allocations for different economic sectors in a drought. Using the UK as a case study, we develop estimates of the minimum potential economic impact associated with different water allocations under a range of climate and policy scenarios. Estimates of total impact range from −0.16% to −1.48% of total output depending on the drought scenarios tested. The approach offers the flexibility to set different policy objectives in terms of water allocations/restrictions, employment or a range of other objectives, including constraints to rebalance the economic system. In allowing for the inclusion of other economic, social, and environmental constraints, it provides a framework for policymakers to assess how water allocation decisions interact with other policy goals to determine the economic impacts of a drought. Challenging decisions about how to allocate water during a drought are likely to remain important in the future.
Comparing Topological Partitioning Methods for District Metered Areas in the Water Distribution Network
Authors: Liu Haixing , Zhao Mengke , Zhang Chi , Fu Guangtao
Published: March 2018

This paper presents a comparative analysis of three partitioning methods, including Fast Greedy, Random Walk, and Metis, which are commonly used to establish the district metered areas (DMAs) in water distribution systems. The performance of the partitioning methods is compared using a spectrum of evaluation indicators, including modularity, conductance, density, expansion, cuts, and communication volume, which measure different topological characteristics of the complex network. A complex water distribution network EXNET is used for comparison considering two cases, i.e., unweighted and weighted edges, where the weights are represented by the demands. The results obtained from the case study network show that the Fast Greedy has a good overall performance. Random Walk can obtain the relative small cut edges, but severely sacrifice the balance of the partitions, in particular when the number of partitions is small. The Metis method has good performance on balancing the size of the clusters. The Fast Greedy method is more effective in the weighted graph partitioning. This study provides an insight for the application of the topology-based partitioning methods to establish district metered areas in a water distribution network.
Bromate Reduction by Iron(II) during Managed Aquifer Recharge: A Laboratory-Scale Study
Authors: Wang Feifei , Salgado Vanida , Van der Hoek Jan , Van Halem Doris
Published: March 2018

The removal of bromate (BrO3−) as a byproduct of ozonation in subsequent managed aquifer recharge (MAR) systems has so far gained little attention. This preliminary study with anoxic batch experiments was executed to explore the feasibility of chemical BrO3− reduction in Fe-reducing zones of MAR systems and to estimate potential inhibition by NO3−. Results show that the reaction rate was affected by initial Fe2+/BrO3− ratios and by pH. The pH dropped significantly due to the hydrolysis of Fe3+ to hydrous ferric oxide (HFO) flocs. These HFO flocs were found to adsorb Fe2+, especially at high Fe2+/BrO3− ratios, whereas at low Fe2+/BrO3− ratios, the mass sum loss of BrO3− and Br− indicated intermediate species formation. Under MAR conditions with relatively low BrO3− and Fe2+ concentrations, BrO3− can be reduced by naturally occurring Fe2+, as the extensive retention time in MAR systems will compensate for the slow reaction kinetics of low BrO3− and Fe2+ concentrations. Under specific flow conditions, Fe2+ and NO3− may co-occur during MAR, but NO3− hardly competes with BrO3−, since Fe2+ prefers BrO3− over NO3−. However, it was found that when NO3− concentration exceeds BrO3− concentration by multiple orders of magnitude, NO3− may slightly inhibit BrO3− reduction by Fe2+.
Assessment of Baseflow Estimates Considering Recession Characteristics in SWAT
Authors: Lee Jimin , Kim Jonggun , Jang Won , Lim Kyoung , Engel Bernie
Published: March 2018

Baseflow is influenced by incoming groundwater to aquifers and is closely related to watershed characteristics. Understanding baseflow characteristics is of great importance to river ecosystems and water management. Baseflow estimation typically depends on the observed streamflow in gauged watersheds, but accurate predictions of streamflow through modeling can also be useful in estimating baseflow. However, uncertainty occurs in the baseflow estimation process when modeling streamflow. Therefore, the purpose of this study is to compare the method that is proposed by Arnold and Allen (Scenario I) to an improved recession prediction method where the alpha factor (baseflow recession coefficient) is recalibrated and is applied to SWAT (Scenario II). Although the differences between the results (NSE, R2, RMSE, MAE, d) of Scenarios I and II were small regarding streamflow and recession, the Scenario II method more accurately reflected the recession characteristics than the Scenario I method. Furthermore, the Scenario II method was better in baseflow prediction than for the Scenario I method proposed by Arnold and Allen. Therefore, these outputs pave the way and contribute to an efficient method for water management in watersheds.
Fog Water Collection: Challenges beyond Technology
Authors: Qadir Manzoor , Jiménez Gabriela , Farnum Rebecca , Dodson Leslie , Smakhtin Vladimir
Published: March 2018

The Sustainable Development Goal (SDG) 6, calling for access to safe water and sanitation for all by the year 2030 supports the efforts in water-scarce countries and regions to go beyond conventional resources and tap unconventional water supplies to narrow the water demand-supply gap. Among the unconventional water resources, the potential to collect water from the air, such as fog harvesting, is by far the most under-explored. Fog water collection is a passive, low maintenance, and sustainable option that can supply fresh drinking water to communities where fog events are common. Because of the relatively simple design of fog collection systems, their operation and maintenance are minimal and the associated cost likewise; although, in certain cases, some financially constrained communities would need initial subsidies. Despite technology development and demonstrated benefits, there are certain challenges to fog harvesting, including lack of supportive policies, limited functional local institutions, inexpert communities, gender inequality, and perceived high costs without undertaking comprehensive economic analyses. By addressing such challenges, there is an opportunity to provide potable water in areas where fog intensity and duration are sufficient, and where the competition for clean water is intensifying because water resources are at a far distance or provided by expensive sources.
Model-Based Analysis of the Potential of Macroinvertebrates as Indicators for Microbial Pathogens in Rivers
Authors: Jerves-Cobo Rubén , Córdova-Vela Gonzalo , Iñiguez-Vela Xavier , Díaz-Granda Catalina , Van Echelpoel Wout , Cisneros Felipe , Nopens Ingmar , Goethals Peter L. M.
Published: March 2018

The quality of water prior to its use for drinking, farming or recreational purposes must comply with several physicochemical and microbiological standards to safeguard society and the environment. In order to satisfy these standards, expensive analyses and highly trained personnel in laboratories are required. Whereas macroinvertebrates have been used as ecological indicators to review the health of aquatic ecosystems. In this research, the relationship between microbial pathogens and macrobenthic invertebrate taxa was examined in the Machangara River located in the southern Andes of Ecuador, in which 33 sites, according to their land use, were chosen to collect physicochemical, microbiological and biological parameters. Decision tree models (DTMs) were used to generate rules that link the presence and abundance of some benthic families to microbial pathogen standards. The aforementioned DTMs provide an indirect, approximate, and quick way of checking the fulfillment of Ecuadorian regulations for water use related to microbial pathogens. The models built and optimized with the WEKA package, were evaluated based on both statistical and ecological criteria to make them as clear and simple as possible. As a result, two different and reliable models were obtained, which could be used as proxy indicators in a preliminary assessment of pollution of microbial pathogens in rivers. The DTMs can be easily applied by staff with minimal training in the identification of the sensitive taxa selected by the models. The presence of selected macroinvertebrate taxa in conjunction with the decision trees can be used as a screening tool to evaluate sites that require additional follow up analyses to confirm whether microbial water quality standards are met.
Comprehensive Forecast of Urban Water-Energy Demand Based on a Neural Network Model
Authors: Yin Ziyi , Jia Benyou , Wu Shiqiang , Dai Jiangyu , Tang Deshan
Published: March 2018

Water-energy nexus has been a popular topic of rese arch in recent years. The relationships between the demand for water resources and energy are intense and closely connected in urban areas. The primary, secondary, and tertiary industry gross domestic product (GDP), the total population, the urban population, annual precipitation, agricultural and industrial water consumption, tap water supply, the total discharge of industrial wastewater, the daily sewage treatment capacity, total and domestic electricity consumption, and the consumption of coal in industrial enterprises above the designed size were chosen as input indicators. A feedforward artificial neural network model (ANN) based on a back-propagation algorithm with two hidden layers was constructed to combine urban water resources with energy demand. This model used historical data from 1991 to 2016 from Wuxi City, eastern China. Furthermore, a multiple linear regression model (MLR) was introduced for comparison with the ANN. The results show the following: (a) The mean relative error values of the forecast and historical urban water-energy demands are 1.58 % and 2.71%, respectively; (b) The predicted water-energy demand value for 2020 is 4.843 billion cubic meters and 47.561 million tons of standard coal equivalent; (c) The predicted water-energy demand value in the year 2030 is 5.887 billion cubic meters and 60.355 million tons of standard coal equivalent; (d) Compared with the MLR, the ANN performed better in fitting training data, which achieved a more satisfactory accuracy and may provide a reference for urban water-energy supply planning decisions.
Experimental and Numerical Investigation of Pre-Breaking and Breaking Vorticity within a Plunging Breaker
Authors: De Padova Diana , Brocchini Maurizio , Buriani Federica , Corvaro Sara , De Serio Francesca , Mossa Michele , Sibilla Stefano
Published: March 2018

The characteristics of vorticity induced just prior and at the splash-down of a plunging breaker on a 1:10 planar slope have been studied using wave flume experiments and numerical simulations. Laboratory experiments involved detailed measurements in the outer surf zone of both fluid velocities below trough level, achieved by a fibre-optic laser-Doppler anemometer, and water surface elevations, obtained by an ultrasound probe. A Weakly-Compressible Smoothed Particle (WCSPH) model, coupled with a two-equation model for turbulent stresses, has been employed for the numerical simulations. A thorough calibration of the SPH’s numerical parameters has been first performed, through comparison between numerical and experimental wave elevation and velocity data. Then, considering that time-averaged laboratory data shows a significant vorticity beneath the free surface in the wave pre-breaking region, the vorticity generation mechanism has been thoroughly analyzed by means of the numerical model. In the attempt of explaining the generation of vorticity as induced by flow separation, we also inspected the role of the streamwise flow deceleration and surface-parallel vorticity flux. In analogy with the case of spilling breakers a cause-effect relation has been observed between streamwise flow deceleration and vorticity generation. Numerical findings are positively confirmed by the experimental results.
Computer screening for palliative care needs in primary care: a mixed-methods study
Authors: Mason Bruce , Boyd Kirsty , Steyn John , Kendall Marilyn , Macpherson Stella , Murray Scott A
Published: March 2018

Background

Though the majority of people could benefit from palliative care before they die, most do not receive this approach, especially those with multimorbidity and frailty. GPs find it difficult to identify such patients.

Aim

To refine and evaluate the utility of a computer application (AnticiPal) to help primary care teams screen their registered patients for people who could benefit from palliative care.

Design and setting

A mixed-methods study of eight GP practices in Scotland, conducted in 2016–2017.

Method

After a search development cycle the authors adopted a mixed-methods approach, combining analysis of the number of people identified by the search with qualitative observations of the computer search as used by primary care teams, and interviews with professionals and patients.

Results

The search identified 0.8% of 62 708 registered patients. A total of 27 multidisciplinary meetings were observed, and eight GPs and 10 patients were interviewed. GPs thought the search identified many unrecognised patients with advanced multimorbidity and frailty, but were concerned about workload implications of assessment and care planning. Patients and carers endorsed the value of proactive identification of people with advanced illness.

Conclusion

GP practices can use computer searching to generate lists of patients for review and care planning. The challenges of starting a conversation about the future remain. However, most patients regard key components of palliative care (proactive planning, including sharing information with urgent care services) as important. Screening for people with deteriorating health at risk from unplanned care is a current focus for quality improvement and should not be limited by labelling it solely as ‘palliative care’.
Acceptability of text messages for safety netting patients with low-risk cancer symptoms: a qualitative study
Authors: Hirst Yasemin , Lim Anita Wey Wey
Published: March 2018

Background

Safety netting is an important diagnostic strategy for patients presenting to primary care with potential (low-risk) cancer symptoms. Typically, this involves asking patients to return if symptoms persist. However, this relies on patients re-appraising their symptoms and making follow-up appointments, which could contribute to delays in diagnosis. Text messaging is increasingly used in primary care to communicate with patients, and could be used to improve safety netting.

Aim

To explore the acceptability and feasibility of using text messages to safety net patients presenting with low-risk cancer symptoms in GP primary care (txt-netting).

Design and setting

Qualitative focus group and interview study with London-based GPs.

Method

Participants were identified using convenience sampling methods. Five focus groups and two interviews were conducted with 22 GPs between August and December 2016. Sessions were audiorecorded, transcribed verbatim, and analysed using thematic analysis.

Results

GPs were amenable to the concept of using text messages in cancer safety netting, identifying it as an additional tool that could help manage patients and promote symptom awareness. There was wide variation in GP preferences for text message content, and a number of important potential barriers to txt-netting were identified. Concerns were raised about the difficulties of conveying complex safety netting advice within the constraints of a text message, and about confidentiality, widening inequalities, and workload implications.

Conclusion

Text messages were perceived to be an acceptable potential strategy for safety netting patients with low-risk cancer symptoms. Further work is needed to ensure it is cost-effective, user friendly, confidential, and acceptable to patients.
RANDOM WALKS AND MARKET EFFICIENCY: EVIDENCE FROM REAL ESTATE INVESTMENT TRUSTS (REIT) SUBSECTORS
Authors: ALMUDHAF Fahad , HANSZ Andrew J.
Published: March 2018

This paper investigates the random walk behavior of real estate investment trust (REIT) subsectors using monthly return data from January 1994 to July 2015. Using variance ratio tests, we examine subsectors of lodging/resorts and self-storage and find that they do not follow a random walk, contradicting the weak-form efficient market hypothesis. Non-parametric runs tests help us find that office, industrial, mixed, free standing, shopping centers, apartments, manufactured homes, and timberland subsectors are weak-form efficient. The evidence in this study supports the idea that some subsec-tors are more informationally efficient than other subsectors.
STAKEHOLDERS’ PERSPECTIVES ON THE SUCCESS CRITERIA FOR PUBLIC-PRIVATE PARTNERSHIP PROJECTS
Authors: OSEI-KYEI Robert , CHAN Albert P. C.
Published: March 2018

Given the complexity and wide stakeholder interests in public-private partnership (PPP) projects, different parties have different expectations and definitions of PPP project success. This paper explores the perceptual differences on the success criteria for PPP projects among PPP stakeholders. A questionnaire survey was conducted with targeted international PPP experts from the academic, public and private sectors. The research findings show that each stakeholder group considers effective risk management as the most critical success criterion. Moreover, the public and private sectors consider meeting output specifications as the second most critical criteria, whereas the academic sector considers satisfying the need for public facility/service. Further analysis using non parametric tests shows significant differences on the ranking of the criterion, “satisfying the need for public facility/service” between the public and private sectors and between academic and private sectors. These research outputs provide significant insights into how PPP projects’ success is evaluated by various PPP stakeholders.
MANAGEMENT OF CAPITAL ASSETS BY LOCAL GOVERNMENTS: AN ASSESSMENT AND BENCHMARKING SURVEY
Authors: KAGANOVA Olga , TELGARSKY Jeffrey
Published: March 2018

There is a growing recognition of the importance of government-owned capital assets, both conceptually and in practice, in large part due to the 2008 global financial crisis. However, a sizeable gap remains between the academic and professional “universe of knowledge” surrounding government asset management, and the actual asset management practiced by governments. In particular, the majority of governments around the world are wholly uninformed when it comes to good asset management. The purpose of this paper is to reduce this gap and suggest an instrument specifically for local governments, for the evaluation of their asset management, in order to help them to identify the weakest elements of asset management and thus focus limited resources on improving these elements. The instrument consists of essentially a composite image of good asset management practices for three main asset types: buildings, land, and infrastructure. The instrument specifies each asset management practice by its key characteristics and then converts each characteristic into a survey question. Answers are scored and a total score for each asset type is calculated. The assessment instrument can be used by local governments, their advisers, and by researchers interested in comparative analysis of asset management in different jurisdictions or countries.
An X-Ray Imaging Survey of Quasar Jets: The Complete Survey
Authors: Marshall H. L. , Gelbord J. M. , Worrall D. M. , Birkinshaw M. , Schwartz D. A. , Jauncey D. L. , Griffiths G. , Murphy D. W. , Lovell J. E. J. , Perlman E. S. , Godfrey L.
Published: March 2018

We present Chandra X-ray imaging of a flux-limited sample of flat spectrum radio-emitting quasars with jet-like structure. X-rays are detected from 59% of 56 jets. No counter-jets were detected. The core spectra are fitted by power-law spectra with a photon index Γ
x
, whose distribution is consistent with a normal distribution, with a mean of 1.61+0.04
−0.05 and dispersion of 0.15+0.04
−0.03. We show that the distribution of α

rx
, the spectral index between the X-ray and radio band jet fluxes, fits a Gaussian with a mean of 0.974 ± 0.012 and dispersion of 0.077 ± 0.008. We test the model in which kiloparsec-scale X-rays result from inverse Compton scattering of cosmic microwave background photons off the jet’s relativistic electrons (the IC-CMB model). In the IC-CMB model, a quantity Q computed from observed fluxes and the apparent size of the emission region depends on redshift as (1 + z)3+α
. We fit Q ∝ (1 + z)
a
, finding a = 0.88 ± 0.90, and reject at 99.5% confidence the hypothesis that the average α

rx
depends on redshift in the manner expected in the IC-CMB model. This conclusion is mitigated by a lack of detailed knowledge of the emission region geometry, which requires deeper or higher resolution X-ray observations. Furthermore, if the IC-CMB model is valid for X-ray emission from kiloparsec-scale jets, then the jets must decelerate on average: bulk Lorentz factors should drop from about 15 to 2–3 between parsec and kiloparsec scales. Our results compound the problems that the IC-CMB model has in explaining the X-ray emission of kiloparsec-scale jets.
The SAMI Galaxy Survey: Gravitational Potential and Surface Density Drive Stellar Populations. I. Early-type Galaxies
Authors: Barone Tania M. , D’Eugenio Francesco , Colless Matthew , Scott Nicholas , Sande Jesse van de , Bland-Hawthorn Joss , Brough Sarah , Bryant Julia J. , Cortese Luca , Croom Scott M. , Foster Caroline , Goodwin Michael , Konstantopoulos Iraklis S. , Lawrence Jon S. , Lorente Nuria P. F. , Medling Anne M. , Owers Matt S. , Richards Samuel N.
Published: March 2018

The well-established correlations between the mass of a galaxy and the properties of its stars are considered to be evidence for mass driving the evolution of the stellar population (SP). However, for early-type galaxies (ETGs), we find that g − i color and stellar metallicity [Z/H] correlate more strongly with gravitational potential Φ than with mass M, whereas SP age correlates best with surface density Σ. Specifically, for our sample of 625 ETGs with integral-field spectroscopy from the Sydney-AAO Multi-object Integral-field Galaxy Survey, compared to correlations with mass, the color–Φ, [Z/H]–Φ, and age–Σ relations show both a smaller scatter and a lower residual trend with galaxy size. For the star formation duration proxy [α/Fe], we find comparable results for trends with Φ and Σ, with both being significantly stronger than the [α/Fe]–M relation. In determining the strength of a trend, we analyze both the overall scatter, and the observational uncertainty on the parameters, in order to compare the intrinsic scatter in each correlation. These results lead us to the following inferences and interpretations: (1) the color–Φ diagram is a more precise tool for determining the developmental stage of the SP than the conventional color–mass diagram; and (2) gravitational potential is the primary regulator of global stellar metallicity, via its relation to the gas escape velocity. Furthermore, we propose the following two mechanisms for the age and [α/Fe] relations with Σ: (a) the age–Σ and [α/Fe]–Σ correlations arise as results of compactness-driven quenching mechanisms; and/or (b) as fossil records of the

relation in their disk-dominated progenitors.
Sun-sized Water Vapor Masers in Cepheus A
Authors: Sobolev A. M. , Moran J. M. , Gray M. D. , Alakoz A. , Imai H. , Baan W. A. , Tolmachev A. M. , Samodurov V. A. , Ladeyshchikov D. A.
Published: March 2018

We present the first VLBI observations of a Galactic water maser (in Cepheus A) made with a very long baseline interferometric array involving the RadioAstron Earth-orbiting satellite station as one of its elements. We detected two distinct components at −16.9 and 0.6 km s−1 with a fringe spacing of 66 μas. In total power, the 0.6 km s−1 component appears to be a single Gaussian component of strength 580 Jy and width of 0.7 km s−1. Single-telescope monitoring showed that its lifetime was only eight months. The absence of a Zeeman pattern implies the longitudinal magnetic field component is weaker than 120 mG. The space–Earth cross power spectrum shows two unresolved components smaller than 15 μas, corresponding to a linear scale of 1.6 × 1011 cm, about the diameter of the Sun, for a distance of 700 pc, separated by 0.54 km s−1 in velocity and by 160 ± 35 μas in angle. This is the smallest angular structure ever observed in a Galactic maser. The brightness temperatures are greater than 2 × 1014 K, and the line widths are 0.5 km s−1. Most of the flux (about 87%) is contained in a halo of angular size of 400 ± 150 μas. This structure is associated with the compact H ii region HW3diii. We have probably picked up the most prominent peaks in the angular size range of our interferometer. We discuss three dynamical models: (1) Keplerian motion around a central object, (2) two chance overlapping clouds, and (3) vortices caused by flow around an obstacle (i.e., von Kármán vortex street) with a Strouhal number of about 0.3.
Estimating the Turn-around Radii of Six Isolated Galaxy Groups in the Local Universe
Authors: Lee Jounghun
Published: March 2018

Estimates of the turn-around radii of six isolated galaxy groups in the nearby universe are presented. From the Tenth Data Release of the Sloan Digital Sky Survey, we first select those isolated galaxy groups at redshifts z ≤ 0.05 in the mass range [0.3–1]

whose nearest-neighbor groups are located at distances larger than 15 times their virial radii. Then, we search for a gravitationally interacting web-like structure around each isolated group, which appears as an inclined streak pattern in the anisotropic spatial distribution of the neighboring field galaxies. Out of 59 isolated groups, only seven are found to possess such web-like structures in their neighbor zones, but one of them turns out to be NGC 5353/4, whose turn-around radius was already measured in a previous work and was thus excluded from our analysis. Applying the Turn-around Radius Estimator algorithm devised by Lee et al. to the identified web-like structures of the remaining six target groups, we determine their turn-around radii and show that three out of the six targets have larger turn-around radii than the spherical bound limit predicted by Planck cosmology. We discuss possible sources of the apparent violations of the three groups, including the underestimated spherical bound limit due to the approximation of the turn-around mass by the virial mass.
Arachnids in Bitterfeld amber: A unique fauna of fossils from the heart of Europe or simply old friends?
Authors: Dunlop Jason A. , Kotthoff Ulrich , Hammel Jörg U. , Ahrens Jennifer , Harms Danilo
Published: March 2018

Bitterfeld amber, sometimes referred to as Saxon or Saxonian amber, is a potentially significant but poorly known source of arthropod data for the Palaeogene of northern Europe. An important aspect is a long-standing controversy about the age of this amber: namely whether it is equivalent to, and perhaps merely a southerly extension of, the better-known Baltic amber, or whether it is a unique and geological younger deposit sampling a different fauna. Here, we briefly review the Bitterfeld arachnids with particular emphasis on how these data could be used to elucidate the age of this deposit. Five arachnid orders have been recorded from Bitterfeld amber: spiders (Araneae), acariform mites (Acariformes), parasitiform mites (Parasitiformes), harvestmen (Opiliones) and pseudoscorpions (Pseudoscorpiones). This is a lower diversity than Baltic amber, where scorpions (Scorpiones) and camel spiders (Solifugae) have also been recorded. Spiders are the most comprehensively studied group, with more than 75 described species. Other groups such as pseudoscorpions and mites appear to be very diverse, but are virtually undescribed. Morphological overlap is apparent in the arachnid fauna and 40 species are currently shared between Baltic and Bitterfeld amber whilst 50 species are unique to the Bitterfeld deposit. At the family level overlap is even higher, but in all groups Baltic amber appears more diverse than Bitterfeld. This overlap may be interpreted as evidence for temporal conspecifity of the Baltic and Bitterfeld ambers, albeit with the Bitterfeld and Baltic ambers possibly representing independent localities within a larger Eocene European amber area which also included the Rovno amber from the Ukraine. However, caution should be exercised because the taxonomic foundation for such assumptions is far from comprehensive, most of the material remains to be studied in detail using modern techniques of morphological reconstruction. There are further issues with date estimates because some arachnid groups show extraordinary morphological stasis over time, even at species level, which may bias the analyses available. Here, we review the available knowledge on Bitterfeld arachnids and discuss how a detailed assessment of this fauna, and other arthropod taxa, could be generated. Several natural history museums – including Hamburg and Berlin – as well as private collectors host major assemblages of Bitterfeld fossils which may help to clarify the debate about the age and provenance of the material, and the extent to which (morpho)-species were maintained both over geographical distances and potentially geological time.
The Entrainment and Screening of Returning and Postspawning Adult Salmonids at Irrigation Canals of the Umatilla River, Oregon
Authors: Simpson William G.
Published: March 2018

Anadromous salmonids can be vulnerable to entrainment at diversion intake structures on streams, effectively trapping fish in irrigation canals and removing them from a population. Currently little is known about how the differences in timing and direction of movement among adult salmonids contribute to their risk of entrainment and how successful they are at escaping irrigation canals. Potential routes of escape include passing against water currents and through the headgate of an irrigation canal intake or by navigating through screen and bypass infrastructure primarily designed to return juvenile fish to a stream. In this study, passive integrated transponders (PIT tags) were used to track the movement of adult Chinook Salmon Oncorhynchus tshawytscha (n = 573), Coho Salmon Oncorhynchus kisutch (n = 39), and anadromous Rainbow Trout Oncorhynchus mykiss (steelhead, n = 853) as they entered areas of the Umatilla River basin (Oregon) with irrigation canals and as they attempted to escape irrigation canals after entrainment. Although adult steelhead and spring Chinook Salmon often encountered diversions at similar times, the vast majority of entrained adults were steelhead (94%). Between 2% and 8% of adult steelhead observed entering the area were entrained. The entrainment of steelhead was strongly associated with downstream movements and Umatilla River discharge below 40 m3/s. Many downstream-moving steelhead were postspawning fish (kelts). As a result, vulnerability of anadromous adults to entrainment differed by species due to the direction of their movements and how these movements coincide with canal operations and river flows. It is unlikely that the screened irrigation canals acted as an ecological sink; the majority of adult salmonids approached the screen and bypass infrastructure (≥88%) and later river detection confirmed that many had used that infrastructure to return to the river (≥47%). However, half of steelhead appeared to experience bypass delays at fish screens. Adult steelhead that approached the canal headgate after becoming trapped in the canal did not successfully return to the Umatilla River using this route. Unscreened irrigation canals elsewhere may disproportionally trap downstream-moving steelhead, like postspawning kelts, due to their propensity for entrainment and their difficulties escaping through the water intakes of irrigation canals. In streams with anadromous salmonids, fish screen and bypass infrastructure primarily designed to eliminate the permanent entrainment of juvenile fish can also prevent the removal of adult fish that may reproductively contribute to the population.