bluuebunny/crossref_metadata_2025 huggingface dataset:
Peplospheric Influences on Local Greenhouse Gas and Aerosol Variability at the Lamezia Terme WMO/GAW Regional Station in Calabria, Southern Italy: A Multiparameter Investigation
Authors: D’Amico Francesco , Calidonna Claudia Roberta , Ammoscato Ivano , Gullì Daniel , Malacaria Luana , Sinopoli Salvatore , De Benedetto Giorgia , Lo Feudo Teresa
Published: November 2024

One of the keys towards sustainable policies and advanced air quality monitoring is the detailed assessment of all factors that affect the surface concentrations of greenhouse gases (GHGs) and aerosols. While the development of new atmospheric tracers can pinpoint emission sources, the atmosphere itself plays a relevant role even at local scales: Its dynamics can increase, or reduce, surface concentrations of pollutants harmful to human health and the environment. PBL (planetary boundary layer), or peplospheric, variability is known to affect such concentrations. In this study, an unprecedented characterization of PBL cycles and patterns is performed at the WMO/GAW regional coastal site of Lamezia Terme (code: LMT) in Calabria, Southern Italy, in conjunction with the analysis of key GHGs and aerosols. The analysis, accounting for five months of 2024 data, indicates that peplospheric variability and wind regimes influence the concentrations of key GHGs and aerosols. In particular, PBLH (PBL height) patterns have been tested to further influence the surface concentrations of carbon monoxide (CO), black carbon (BC), and particulate matter (PM). This research introduces four distinct wind regimes at LMT: breeze, not complete breeze, eastern synoptic, and western synoptic, each with its peculiar influences on the local transport of gases and aerosols. This research demonstrates that peplosphere monitoring needs to be considered when ensuring optimal air quality in urban and rural areas.
Blockchain Technology for IoT Security and Trust: A Comprehensive SLR
Authors: Almarri Seetah , Aljughaiman Ahmed
Published: November 2024

After the emergence of the Internet of Things (IoT), the way devices interact with each other changed, as it allowed automation and seamless communication in various fields. However, various challenges related to security and trust have emerged, hindering the widespread adoption of the IoT. Blockchain technology is considered the ideal solution to face these challenges because of its immutable and decentralized nature. This paper explores the potential of blockchain technology to address critical security and trust challenges within the rapidly growing IoT ecosystem. Through a systematic literature review, this study examines how blockchain’s decentralized, immutable, and transparent features contribute to enhancing security and trust in IoT networks. Key findings indicate that blockchain integration can prevent data manipulation, ensure robust identity management, and facilitate transparent, verifiable transactions, supporting both security and trust in IoT systems. These attributes not only improve IoT security but also promote sustainable practices by optimizing resource efficiency, reducing environmental impact, and enhancing resilience in systems like supply chain management and smart grids. Additionally, this study identifies open research challenges and suggests future directions for optimizing blockchain in IoT environments, focusing on scalability, energy-efficient consensus mechanisms, and efficient data processing.
A Study on the Spatial, Structural, and Cultural Differentiation of Traditional Villages in Western Henan Using Geographic Detectors and ArcGIS
Authors: Ge Yipeng , Liu Yang , Ma Yueshan , Qin Zihan , Gan Qizheng , Li Nan
Published: November 2024

Traditional villages are an important cultural heritage left by China’s agrarian civilization and serve as a testament to the historical development of the Chinese nation. The study of spatial and cultural differentiation in traditional villages is significant for their future preservation and development. Existing studies predominantly adopt a macro perspective, focusing on large-scale regions, and lack investigations from a micro perspective in medium- and small-scale areas. This study utilizes ArcGIS 10.8 for spatial analysis, multi-factor geographic detectors, and cultural geography spatial zoning methods to explore the spatial structure and cultural differentiation of 305 traditional villages in western Henan. The results indicate that the distribution of traditional villages in this region is significantly clustered and uneven, primarily concentrated in specific districts of Sanmenxia and Luoyang. Per capita GDP and the distance to roads are negatively correlated with the distribution of traditional settlements, reflecting the positive impact of lower economic levels and remote locations on village preservation. The spatial layout of traditional villages in western Henan exhibits clustering patterns, with cultural zoning characterized by distinct residential forms. This study, through the analysis of the spatial structure characteristics and influencing factors of traditional villages in the western Henan region, provides a new perspective on the formation and evolution of traditional villages, revealing the cultural differentiation characteristics of western Henan. The research results offer directional guidance for the conservation strategies of traditional villages in western Henan and provide a decision-making reference for cultural heritage conservation practices in similar regions.
Large-Scale Origin–Destination Prediction for Urban Rail Transit Network Based on Graph Convolutional Neural Network
Authors: Wang Xuemei , Zhang Yunlong , Zhang Jinlei
Published: November 2024

Due to data sparsity, insufficient spatial relationships, and the complex spatial and temporal characteristics of passenger flow, it is very challenging to achieve a high prediction accuracy on Origin–Destination (OD) in a large urban rail transit network. This paper proposes a two-stage prediction network GCN-GRU, using a Graph Convolutional Network (GCN) with a Gated Recursive Unit (GRU). The GCN can obtain the adjacency relationship between different stations by selecting the adjacent neighborhoods and interacting neighborhoods of a station and capturing the spatial characteristics of the OD passenger flow. Then, an advanced weighted aggregator is employed to gather important information from the two above-mentioned types of neighborhoods to capture the spatial relationship of the network OD passenger flow and to perceive the sparsity and range of the OD data. On the other hand, the GRU can extract the temporal relationship, such as periodicity and other time-varying trends. The effectiveness of GCN-GRU is tested with a real-world urban rail transit dataset. The experimental results show that whether it is the OD passenger flow matrix of each period (one hour) on weekdays and weekends or the single-pair OD passenger flow between stations, the proposed GCN-GRU models perform better than the benchmark models. This study provides an important theoretical basis and practical applications for operators, thus promoting the sustainable development of urban rail transit systems.
Environmental Protection Tax and China’s Economic Growth: Boost or Slowdown?
Authors: Zhao Qing , Yuan Chih-Hung
Published: November 2024

This paper explores the impact of China’s environmental protection tax reform on economic growth through empirical research. Using the “fee to tax” policy implemented in China in 2018 as a natural experiment, the analysis is conducted using a strengthened double-difference (DID) model. It is found that environmental protection tax reform has a significant positive impact on regional economic growth, and this conclusion still holds after several robustness tests. In order to explore the mechanism of environmental protection tax in-depth, this paper analyzes the three dimensions of science and technology innovation investment, foreign direct investment, and tax administration intensity. The results show that environmental protection tax does not promote technological innovation of enterprises as expected, but may instead inhibit R&D and innovation activities by increasing the cost pressure on enterprises. The positive impact of environmental protection tax on economic growth is mainly realized by increasing the intensity of tax administration. Furthermore, this paper analyzes the heterogeneity in urban geographic locations and administrative levels, finding that environmental protection taxes have a significant positive effect on economic growth in central and northeastern regions and in cities with lower administrative levels, while they have a negative effect in the eastern region and in cities with higher administrative levels.
Synthesis of α-Hydroxyethylphosphonates and α-Hydroxyethylphosphine Oxides: Role of Solvents During Optical Resolution
Authors: Szalai Zsuzsanna , Kis Anna Sára , Schindler József , Karaghiosoff Konstantin , Keglevich György
Published: November 2024

Five chiral, racemic dialkyl α-hydroxyethylphosphonates and α-hydroxyethyl-diarylphosphine oxides were prepared in a scalable manner. Possibilities for the optical resolution of the racemic hydroxyphosphine oxides were explored via diastereomeric complex-forming experiments. The acidic calcium salt of O,O′-dibenzoyl-(2R,3R)-tartaric acid and O,O′-di-p-tolyl-(2R,3R)-tartaric acid were chosen as the resolving agents. The role of the solvent in the enantiomeric discrimination was investigated. The diastereomeric complex could be obtained in a crystalline form for α-hydroxyethyl-diphenylphosphine oxide and α-hydroxyethyl-bis(4-methylphenyl)phosphine oxide. However, in the third case, for α-hydroxyethyl-bis(3,5-dimethylphenyl)phosphine oxide, there was no chiral discrimination. Decomposition of the recrystallized diastereomeric complex followed by decomposition of the complex yielded the target compounds in 77/90% enantiomeric excess. The absolute configuration of the hydroxyethyl-diphenylphosphine oxide was determined by single-crystal X-ray diffraction measurements. The interactions stabilizing the supramolecular associate were evaluated.
Environmental Racism in the Accessibility of Urban Green Space: A Case Study of a Metropolitan Area in an Emerging Economy
Authors: Bressane Adriano , Loureiro Anna Isabel Silva , Negri Rogério Galante
Published: November 2024

Urban Green Spaces (UGS) are integral to advancing urban sustainability and improving the quality of life in cities. However, in rapidly urbanizing regions like the São Paulo Metropolitan Region (MRSP), significant environmental injustices in UGS accessibility present a complex challenge that requires in-depth understanding. Notably, existing studies predominantly focus on developed countries, leaving a gap in research concerning emerging economies in the Global South. This study aims to analyze the associations between sociodemographic factors and environmental racism in UGS accessibility within the municipalities of MRSP. The research utilizes Spearman Rank Correlation and multiple linear regression analyses on data sourced from the Brazilian Institute of Geography and Statistics and the Urban Green Data Platform. Key variables include the number of inhabitants, territorial area, population density, urbanization rate, gross domestic product (GDP), human development index (HDI), urban vegetation coverage, UGS per capita, and the difference between the total population and the Black or Indigenous populations residing outside the vicinity of UGSs as an indicator of environmental racism. The findings reveal significant correlations between higher GDP and HDI with increased environmental racism in UGS accessibility, suggesting that, in the absence of equitable policies, economic and human development may exacerbate disparities in green space distribution. Moreover, the study demonstrates that increased urban vegetation coverage is significantly associated with reduced environmental disparities, underscoring the role of urban greenery in mitigating inequality. These results emphasize the need for comprehensive urban planning and targeted policies that prioritize the equitable development of UGS, particularly in underserved areas. Future research should explore longitudinal data to establish causality and consider additional variables such as political governance and cultural factors, which could provide a more comprehensive understanding of environmental racism in UGS accessibility.
The Safety and Efficacy of New DIVA Inactivated Vaccines Against Lumpy Skin Disease in Calves
Authors: Ronchi Gaetano Federico , Iorio Mariangela , Serroni Anna , Caporale Marco , Testa Lilia , Palucci Cristiano , Antonucci Daniela , Capista Sara , Traini Sara , Pinoni Chiara , Di Matteo Ivano , Laguardia Caterina , Armillotta Gisella , Profeta Francesca , Valleriani Fabrizia , Di Felice Elisabetta , Di Teodoro Giovanni , Sacchini Flavio , Luciani Mirella , Di Pancrazio Chiara , Podaliri Vulpiani Michele , Rossi Emanuela , Salini Romolo , Morelli Daniela , Ferri Nicola , Mercante Maria Teresa , Di Ventura Mauro
Published: November 2024

Background: Lumpy skin disease virus (Poxviridae family—Capripoxvirus genus) is the aetiological agent of LSD, a disease primarily transmitted by hematophagous biting, affecting principally cattle. Currently, only live attenuated vaccines are commercially available, but their use is limited to endemic areas. There is a need for safer vaccines, especially in LSD-free countries. This research aims to develop and test a safe and efficacious inactivated vaccine. Moreover, in this study, we used keyhole limpet hemocyanin (KLH) as a positive marker to distinguish infected from vaccinated animals (DIVA). Methods: Lumpy skin disease virus was propagated on primary lamb testis cells and Madin–Darby bovine kidney cells (PLT and MDBK, respectively), and four inactivated vaccines were produced. The vaccines differed from each other with the addition or not of KLH and in cells used for virus propagation. To evaluate the safety and immunogenicity, the vaccines and two placebos were administered to six groups comprising six male calves each, and antibody response was investigated using both an enzyme-linked immunosorbent assay (ELISA) and a serum neutralization (SN) test. In addition, the LSD/γ-interferon test and KLH (IgM-IgG) ELISA were performed on the collected samples. Furthermore, the use of KLH allowed us to distinguish vaccinated animals in the ELISA results, without any interference on the strength of the immune response against the LSDV. Finally, the efficacy of one of four vaccines was investigated through a challenge, in which one group of vaccinated animals and one animal control group were infected with a live field strain of LSDV. Results: Four out of the six control animals showed severe clinical signs suggestive of LSD, and, therefore, were euthanized for overcoming the predetermined limit of clinical score. By contrast, the vaccinated animals showed only mild symptoms, suggesting a reduction in severe disease notwithstanding the incapability of the vaccine in reducing the virus shedding. Conclusion: The vaccines produced were safe and able to elicit both a humoral and a cellular immune response, characteristics that, together with the demonstrated efficacy, make our vaccine a good candidate for countering the LSD spread in disease-free countries, thus also facilitating disease containment throughout the application of a DIVA strategy.
Multiple Endocrine Neoplasia with Multiple PGLs in Two Boxer Dogs: Morphological Features, Immunohistochemical Profile and SDHD Gene Mutation Screening
Authors: Semzenisi Ecaterina , Popa Roxana , Toma Corina , Bâlteanu Valentin-Adrian , Scurtu Iuliu Calin , Pop Romelia , Tăbăran Alexandru-Flaviu
Published: November 2024

This study aimed to describe the gross and histological features of multiple endocrine and non-endocrine neoplasia, including multiple PGLs found in two Boxer dogs. Additionally, the identified PGLs were immunohistochemically evaluated, and the subunits 2, 3, and 4 of the SDHD gene were screened for possible mutations. The tumors identified include aortic and carotid body PGLs, thyroid follicular-compact carcinoma, and subcutaneous lipomas. One case also had a Leydig cell tumor and adrenal cortex hyperplasia, while the other had H-type pancreatic carcinoma. Three out of 4 PGLs appeared benign, but one aortic body tumor showed malignant features with neoplastic emboli at its edge. Immunohistochemical analysis confirmed the neuroendocrine origin of all PGLs, with positive staining for Chromogranin A, NSE, and variable positivity for S100. No somatic mutations were found in exons 2, 3, and 4 of the SDHD gene in any of the evaluated PGLs. The absence of mutations in the evaluated SDHD gene subunits suggests the involvement of other genetic factors or pathways in the development of these tumors, warranting further investigation in this field.
Interactions Between Forest Cover and Watershed Hydrology: A Conceptual Meta-Analysis
Authors: François Mathurin , de Aguiar Terencio Rebello , Mielke Marcelo Schramm , Rousseau Alain N. , Faria Deborah , Mariano-Neto Eduardo
Published: November 2024

The role of trees in watershed hydrology is governed by many environmental factors along with their inherent characteristics and not surprisingly has generated diverse debates in the literature. Herein, this conceptual meta-analysis provides an opportunity to propose a conceptual model for understanding the role of trees in watershed hydrology and examine the conditions under which they can be an element that increases or decreases water supply in a watershed. To achieve this goal, this conceptual meta-analysis addressed the interaction of forest cover with climatic conditions, soil types, infiltration, siltation and erosion, water availability, and the diversity of ecological features. The novelty of the proposed conceptual model highlights that tree species and densities, climate, precipitation, type of aquifer, and topography are important factors affecting the relationships between trees and water availability. This suggests that forests can be used as a nature-based solution for conserving and managing natural resources, including water, soil, and air. To sum up, forests can reduce people’s footprint, thanks to their role in improving water and air quality, conserving soil, and other ecosystem services. The outcomes of this study should be valuable for decision-makers in understanding the types of forests that can be used in an area, following an approach of environmental sustainability and conservation aiming at restoring hydrological services, mitigating the costs of environmental services, promoting sustainable land use, managing water resources, and preserving and restoring soil water availability (SWA) when investing in reforestation for watershed hydrology, which is important for the human population and other activities.
METHODOLOGICAL ASPECTS OF MODELLING THE HEALTH-DEVELOPING ENVIRONMENT OF A MODERN EDUCATIONAL INSTITUTION
Authors: Dudko S.
Published: November 2024

The article deals with the methodological bases of modeling the health-developing environment of a modern educational institution and the implementation of health-saving educational technologies in general secondary educational institutions, especially in the conditions of martial law in Ukraine. By evaluating the works of N. Beseda, O. Vashchenko, N. Makarenko, N. Polishchuk, L. Romanenko, and L. Rybalko, the key functions of these technologies, such as formative, informational and communicative, diagnostic, adaptive, reflective, and integrative, are identified and classified into medical and hygienic, physical culture and health, environmental and recreational, safety and health development, each of which has its specific methods and forms of implementation. Scientific approaches are considered, including systemic, activity, competence, integrative, environmental, and personal, reflecting different aspects of health promotion in the educational process.
Emphasis is placed on the latest technology, such as safety lessons for students in grades 5-6, which ensure the formation of responsibility for health and safety, mastering the basics of safe behavior in emergencies, and improving life skills. The methodological features of safety lessons, which include active teaching methods, group work, situational tasks, and the use of didactic games, are considered.
The article describes the arrangement of safety classes as centers of health-saving educational technologies, in particular, their equipment with modern multimedia tools for conducting training sessions. The considered approaches and methods have been implemented in the educational process of the general secondary schools of Poltava city and Poltava region, which confirms their effectiveness in ensuring the safety and health of students under martial law. The technologies and developed educational and methodological materials that have been comprehensively used to implement the author’s logical and functional model in the general secondary education institutions of Poltava city and Poltava region are described.
Evolução do estado nutricional frente ao diagnóstico de artrogripose: estudo de caso
Authors: Salgueiro Camila Aparecida , Vanelli Chislene Pereira
Published: November 2024

Introdução: A Artrogripose Múltipla Congênita (AMC) é uma síndrome rara que engloba um conjunto de condições congênitas não progressivas com sintomatologia clínica caracterizada por contraturas em duas ou mais articulações, podendo afetar outros sistemas do corpo, levando a dificuldades de nutrição e podendo ser necessário o uso de vias alternativas de alimentação. O diagnóstico é essencialmente clínico e não possui tratamento definitivo, objetivando a melhora da qualidade de vida e da autonomia do paciente. Objetivo: Relatar o caso de uma paciente portadora de AMC com dificuldades de sucção e ganho de peso admitida em internação no Hospital Universitário da Universidade Federal de Juiz de Fora (HU-UFJF) encaminhada pelo Programa de Follow-up de Recém-nascidos de Alto Risco, no qual realizava acompanhamento. Relato de Caso: Paciente, sexo feminino, 3 meses e 16 dias no momento da internação. Ao exame físico apresentava fácies típicas, orelhas com baixa implantação, com pavilhão auricular dismorfe, exoftalmia, hipertelorismo ocular, estrição de mobilidade articular, pé torto congênito bilateral e mãos em garra. Instalado catéter orogástrico visto a ineficiência da sucção e de deglutição. A reabilitação nutricional ocorreu de forma multiprofissional e com participação da família, proporcionando uma alta segura com consumo alimentar total por via oral. Discussão: Cerca de 25% dos pacientes possuem acometimento da região oral e maxilofacial, podendo prejudicar a alimentação e necessitando de vias alternativas de nutrição. A reabilitação depende de diversos fatores e da cooperação sinérgica entre cuidadores e profissionais. Conclusão: A AMC frequentemente está relacionada a outras síndromes, é importante o acompanhamento multiprofissional para proporcionar maior qualidade de vida e independência aos portadores.
Removing Barriers to Create Sustainable Leaders in Extension: The Odyssey of Leadership Development
Authors: Griffeth Lauren , Burnsed Joel
Published: November 2024

Leadership development programs are an exploratory journey that develop Extension faculty to better themselves in service to the organization. In an effort to mitigate potential barriers for participants, it is imperative that organizations work to create conditions conducive for success. We posit barriers for extension professionals include, participants having a fixed-mindset (Dweck, 2016), time constraints (Lindle, 2015; McAlearney, 2006), and the employee burnout epidemic (Fisher, 2018; Seppala & Moeller, 2021). Proactively working against common negative influences, sets up leadership program participants to become more fully immersed in learning and subsequently have a better chance for a positive behavior change.
AviateOK: A STEM App to Increase K-12 Student Engagement in the Aviation and Aerospace Industry
Authors: Miller Irene , Rutledge Amy , Bliss Timm
Published: November 2024

STEM industries are driving technological and economic growth across the globe. To remain competitive, the U.S. needs to focus on the advancement of STEM education and develop a sustainable pipeline to provide a well-qualified workforce to STEM-related industries. The Department of Aviation and Space Education (AVED) at Oklahoma State University (OSU) has developed aviateOK, which is a STEM application, to provide aviation/aerospace content to students, parents, and extension educators. The aviateOK STEM application promotes extension education by providing access to free activities and resources for grades K-12. AviateOK equips 4-H youth programs with the resources needed for extension educators to provide a quality STEM education and ignite in students a passion for STEM.
Paper Origami for Program Development and Evaluation Training of New Extension Employees
Authors: Majumdar Ayavana
Published: November 2024

This article describes the use of paper origami as a training tool for Extension evaluation and capacity building workshops. Three paper origami models have been developed and used consistently since 2021 to benefit 131 new Extension professionals. The use of these models added an element of pleasant surprise for workshop participants and fostered collaboration during training. This article describes the construction and usefulness of the origami models to these new employees. Post-event feedback and testimonials are very encouraging to authors who continue to develop additional origami models for training and motivation.
Beyond Direct Education and Facilitation: Revisiting the Role of Extension in Community & Regional Food Systems Development
Authors: DeMets Catie , Farnsworth Lindsey
Published: November 2024

The fundamental issues that community and regional food systems aim to address are inherently systems problems, yet many Extension programs continue to focus food system development efforts on activities and actors that directly support the food value chain. While important, the impact of these interventions is limited. Drawing from interviews with directors of four of the nation’s leading Community and Regional Food Systems Extension programs, this article makes a case for rethinking Extension’s role in community and regional food systems development in relationship to key leverage points through a typology of Extension roles and corresponding examples.
TRANSFORMATION OF NATIONAL LOCAL SELF-GOVERNMENT LEGISLATION UNDER MARTIAL LAW
Authors:   Mariupol State University, Kysil V.
Published: November 2024

The article focuses on the transformation of Ukrainian legislation regulating local self-government bodies. The author analyses in detail constitutional provisions relating to the representation of public authorities at the local level and their correlation with the main sectoral regulations. The publication, in addition to reviewing the content of the Constitution and sectoral laws, offers the author's analysis of amendments to the texts of sectoral laws on local self-government in the process of their elaboration by the Verkhovna Rada during 2014-2024 - the period of Russia's hybrid aggression against Ukraine and full-scale invasion. The article states that there are a number of contradictions between the Constitution, sectoral regulations and fundamental documents of European law relating to the problems of local self-government. Special attention is paid to the legislation regulating civil-military administrations, which combine the features of state authorities and local self-government bodies. Thus, a legal conflict arises that levels the independence of local self-government bodies in the system of public authority guaranteed by the Constitution of Ukraine. The Law ‘On the Legal Regime of Martial Law’ emphasises the possibility of establishing military-civilian administrations, which are essentially state administrations, but can also perform the functions of local self-government bodies in case of termination of the latter's functioning, their self-dissolution, cooperation with the enemy, etc. Local self-government bodies may also participate in procedures related to the temporary restriction of a number of constitutional freedoms of residents of a territorial community - the list of these restrictions is clearly spelled out in the Law on the Legal Regime of Martial Law. These functions should be performed by local authorities in cooperation with state administrations and military command. The article focuses on legislative changes in the process of implementing the concept of decentralisation of power, which was at its peak during the period of the Russian Federation's hybrid aggression against Ukraine. The analytical part of the study highlights a number of positive aspects of decentralisation reforms that have made it possible to strengthen certain aspects of the state's defence capability at the local level, namely: strengthening the budgetary autonomy of territorial communities, the possibility of additional funding for territorial defence units, assistance in mobilisation activities, etc. However, the situation is complicated by the fact that a significant part of these provisions is either ignored by communities or contradicts internal bylaws. Key words: local self-government bodies, martial law, public authority, special legal regime, Constitution of Ukraine, territorial communities.
مؤسسات التّعليم الْعالي بالجزائر ودورها الدّاعم للابتكار وريادة الأعمال
Authors: Safi Fatiha , Beldjilali Fatiha
Published: November 2024

تسعى الدراسة إلى التعرف على مدى اسهام مؤسسات التعليم العالي في دعم الابتكار وريادة الأعمال وخلق مشاريع ريادية، وكذا تبيان أهم الاستراتيجيات المتبناة من طرف  الدولة الجزائرية لتجعل من هذه المؤسسات منطلقا للإبداع والابتكار والقرار الوزاري 1275 كأهمها.
وتوصلت النتائج إلى أن هذا القرار خلق دينامكية في وسط مؤسسات التعليم العالي ولاقى ترحيب الأساتذة والطلبة، بحيث تم اعداد مئات المذكرات في اطاره ومناقشة العشرات منها، ولا تزال المئات منها في طور الإنجاز كما أن اللجنة  المنشأة من خلاله والمتمثلة في اللجنة الوطنية التنسيقية لمتابعة الابتكار وحاضنات الأعمال الجامعية حققت مهامها المنشودة والمتمثلة في التكوين والمرافقة وكذا تمكنت مبادرة تحدي الابتكار من العصف بالأفكار المتميزة، وإشعال حمى التنافس بين الطلبة، لذلك على الجهات المعنية محاولة التقليل من مخاوف الطلبة اتجاه  طرح الفكرة وإعداد المذكرة التي ستحول إلى مؤسسة ناشئة خصوصا وأن المدة الزمنية المخصصة لذلك هي بضع أشهر، و إعطاء فرصة لطلبة السنوات الأخرى لطرح أفكارهم وإشراكهم في اعداد المشاريع الريادية من خلال البحوث ومخططات الأعمال.
جودة الأصول بالقطاع المصرفي الجزائري بين البنوك العمومية والبنوك الخاصة للفترة (2014-2022)
Authors: BADENE Abdelkader , BOUKHARI Boulerbah
Published: November 2024

هدف الدراسة هو تحليل ودراسة مؤشرات جودة الأصول بالقطاع المصرفي الجزائري من خلال المقارنة بين البنوك العمومية والبنوك الخاصة خلال فترة 2014-2022، تم تجميع البيانات من تقارير بنك الجزائر. مع اعتماد ثلاث مؤشرات لجودة الأصول (نسبة القروض المتعثرة الصافية من المؤونات إلى رأس المال الخاص القانوني NPL1 ونسبة القروض المتعثرة NPL2) حسب دليل مؤشرات السلامة المالية لصندوق النقد الدولي، ومؤشر (نسبة مؤونات القروض المتعثرة NPLP) الذي يتعامل به بنك الجزائر، تم استخدام أساليب الإحصاء الوصفي لتحديد المتوسط الحسابي، أعلى وأدنى قيمة للمؤشرات، وأساليب الإحصاء الاستدلالي (اختبارt) لتحديد الفروق بين متوسط مؤشرات جودة الأصول للبنوك العمومية والبنوك الخاصة. تم التوصل إلى وجود فروق دالة احصائيا لمؤشر (NPL1) ومؤشر (NPL2) بين البنوك العمومية والبنوك الخاصة ولصالح البنوك العمومية، ما يعني أنها الأكثر استقرارا ماليا من نظيرتها الخاصة، في حين لا توجد فروق دالة احصائيا لمؤشر NPLP بين البنوك العمومية والبنوك الخاصة. وكاستنتاج فان البنوك العمومية والخاصة لها أصول ذات جودة مقبولة.
A Critical Discourse Analysis of the Inaugural Speech of Trump and its Perception by the American Society
Authors: Yousfi Adnane , Mouhadjer Noreddine
Published: November 2024

This article provides an analysis of Donald Trump's inauguration speech in 2017, employing an approach of critical discourse. Applying Critical Discourse Analysis (CDA) as a theoretical foundation, this analysis investigates the linguistic features, discourse strategies, and thematic elements manifested in the given speech. The article posits that the speech delivered by Trump served as a potent instrument for attacking the entirety of the political establishment within the United States. This exemplifies the various methods by which language can be employed to sway and exert influence over the general populace, as well as to contest prevailing power dynamics. The analysis further emphasizes the need to employ critical discourse analysis as a means of comprehending the manners in which language is employed to influence power dynamics and social change.
Medical tourism as a mechanism to activate substainble development
Authors: MEGUELLATI Aida
Published: November 2024

Tourism is a dynamic activity with mutual and effective influence, which includes all activities in the country inside and outside. It has importance that is reflected on all levels, including the economic, social, cultural and political levels of society, where tourism represents a major leader of development, including local, national and foreign, despite the divergence of economic opinions. However, the scientific evidence and the experiences of countries indicate a significant increase in the role of tourism, especially in development issues in its broad sense. So, medical tourism has become a significant aspect of tourism in various ways, enriching the experiences of both individuals and groups. Their abilities and their energies are renewed, as the latter has a mixture between entertainment and health treatment, specialized centers provide, through hospital centers such as treatment centers for febrile treatment, and usually the adjective combines both
Desenvolvimento de balas de gelatina probióticas sem açúcar adicionado
Authors: Meira Stela Maris Meister , Silva Thainá Martins , Jacques Andressa Carolina , Moura Catarina Motta de , Nalério Élen Silveira , Giongo Citiele , Cogo Sarah Lemos
Published: November 2024

Balas de gelatina comerciais costumam apresentar excesso de açúcares e aditivos químicos, gerando baixa qualidade nutricional. A substituição da sacarose por polióis e a adição de corantes naturais neste tipo de produto, como compostos presentes na casca de ameixa, pode conferir matrizes mais saudáveis a esses confeitos. Além disso, a incorporação de probióticos pode conferir aspectos funcionais a essas matrizes alimentares. Neste contexto, o objetivo do trabalho foi desenvolver e analisar balas de gelatina contendo xilitol e casca de ameixa incorporadas do probiótico comercial Bacillus coagulans. Foram desenvolvidas duas formulações com diferentes quantidades de xilitol (A - 50 g e B - 30 g). As balas de gelatina obtidas foram analisadas quanto aos parâmetros acidez, sólidos solúveis, umidade, cinzas, firmeza, cor, valor energético, antocianinas e viabilidade da bactéria probiótica ao longo de 30 dias. As características físico-químicas das balas diferiram estatisticamente para a maioria dos parâmetros avaliados, com exceção do conteúdo de cinzas e do valor energético. Foi verificada degradação das antocianinas durante o processo de elaboração das balas quando comparado ao teor de antocianinas da casca. As contagens de Bacillus coagulans mantiveram-se entre 6,06 a 6,11 Log UFC/g ao longo da vida de prateleira das balas. A amostra B, com maior teor de antocianinas, foi avaliada quanto à atividade antioxidante atingindo 92,21% de inibição do radical ABTS. Pode-se concluir que o produto obtido revela um potencial inovador, sendo possível uma formulação de balas saudáveis e funcionais à base de gelatina, sem açúcar adicionado contendo probiótico e com características antioxidantes.
Impacto e atribuições de um programa de Stewardship na prevenção e tratamento de infecções primárias de corrente sanguínea: uma revisão integrativa
Authors: Moura André Felipe Teixeira de , Antunes Italo Felipe Alves
Published: November 2024

As infecções relacionadas à assistência à saúde (IRAS) são um crescente problema de saúde pública, especialmente na América Latina, onde sua incidência é significativamente maior do que em outras regiões. A emergência de bactérias multirresistentes agrava essa situação, com até 50% das prescrições de antibióticos realizadas de forma inadequada. Entre as IRAS, as infecções de corrente sanguínea relacionadas ao uso de cateter destacam-se por sua alta prevalência em unidades de terapia intensiva, onde pacientes são particularmente vulneráveis. O programa de Stewardship visa combater essa crise, implementando ações como auditorias e intervenções multidisciplinares para otimizar o uso de antimicrobianos, garantir tratamento adequado e reduzir a resistência bacteriana. Suas estratégias incluem a educação contínua dos profissionais, a confecção de protocolos baseados em evidências, e a avaliação diária da necessidade de dispositivos invasivos, visando a prevenção de infecções relacionadas ao uso de dispositivos e a melhora dos desfechos clínicos.
A importância da protese total na autoestima de pacientes edêntulos – revisão de literatura
Authors: Corrêa Sarah Laís Ferreira , Araújo Ângela Líbia Chagas Amaral
Published: November 2024

A perda dos elementos dentários é aceita pela sociedade como consequência natural do envelhecimento, sendo decorrente do não controle da cárie e doença periodontal, resultante de diferentes fatores biológicos, comportamentais e psicossociais. As próteses totais (PT) são aparelhos mecânicos usados para reabilitação da cavidade oral, devolvendo ao indivíduo edêntulo sua saúde bucal, capacidade mastigatória e uma estética agradável aos padrões da sociedade. Levando em consideração os fatores psicológicos que envolvem os pacientes que perderam os seus dentes, este trabalho objetiva compreender as experiências da perda dentária e evidenciar como a reabilitação com prótese total pode interferir direta e positivamente na autoestima de pacientes edêntulos.
Variações anatômicas do nervo alveolar inferior
Authors: Santos Karly Kazue Sasahara dos , Rêgo Amanda Braga , Ferreira Filho Mario Jorge Souza , Fonseca Tiago Silva da
Published: November 2024

No âmbito da odontologia, o bloqueio do nervo alveolar inferior é um dos mais utilizados; no entanto, vários estudos tem mostrado as mais altas taxas de fracasso, as quais, normalmente, tem como motivo a falha na observação da posição, da forma e da anatomia dos nervos. Objetivo: descrever as variações anatômicas do nervo alveolar inferior. Metodologia: Trata-se de um estudo do tipo  revisão integrativa com o intuito de identificar a produção cientifica e seus principais resultados relacionados ao tema. A pesquisa foi conduzida utilizando bases de dados digitais de artigos científicos, incluindo PubMed, SciELO e Google Acadêmico. Conclusão: É importante para o profissional odontólogo, ter o conhecimento da anatomia do nervo alveolar inferior e suas variações, jpa que é o principal bloqueio realizado em suas práticas cirúrgicas.
Electrolyte and Interphase Chemistry for 4.6-V Lithium Metal Batteries Operated below −30 °C
Authors: Wang Zhongsheng , Zhu Chunlei , Liu Jiandong , Qi Shihan , Ma Jianmin
Published: November 2024

High-voltage lithium metal batteries based on high-nickel layered oxide cathodes are attractive due to their high energy density. However, they suffer from a severe decline in capacity at low temperatures, and the limited voltage range of low-temperature electrolytes fails to meet their application. To address this issue, we developed low-temperature carbonated electrolytes for lithium metal batteries with robust LiP

x

O

y

F

z

- and LiF-rich Li
+
-conductive electrode–electrolyte interphases. The dual interphases with a LiPO
2
F
2
additive could accelerate Li
+
migration, reduce impedance, prevent electrolyte consumption, alleviate cathode degradation, and even mitigate the severe polarization of the Li anode at −50 °C. As a result, a 4.6-V Li||NCM811 cell with an optimized electrolyte sustained 160 cycles before reaching the 80% threshold and sustained a 92% capacity retention rate (139.9 mAh g
−1
) at 20 mA g
−1
/−30 °C after 50 cycles. Moreover, it could deliver 118 mAh g
−1
even at 20 mA g
−1
/−50 °C.
Dual-Functional Additives Boost Zinc-Ion Battery Electrolyte over Wide Temperature Range
Authors: Dai Zhiqiang , Chanajaree Rungroj , Yang Chengwu , Zhang Xueqing , Okhawilai Manunya , Pattananuwat Prasit , Zhang Xinyu , He Guanjie , Qin Jiaqian
Published: November 2024

Traditional aqueous electrolyte systems in zinc-ion batteries (ZIBs) often face challenges such as sluggish ion transfer kinetics, dendrite formation, and sudden battery failures in harsh temperature environments. Herein, we introduce a pioneering approach by integrating a bifunctional additive composed of ethylene glycol (EG) and sodium gluconate (Ga) into ZnSO
4
(ZSO) electrolyte to overcome these obstacles. The polyhydroxy structures of EG and Ga can reconstruct the hydrogen bond network of H
2
O to improve its liquid stability, and also adjust the coordination environment around hydrated Zn
2+
. Additionally, Ga in the H
2
O–EG mixture leads to the formation of a robust protective layer that promotes uniform deposition of Zn
2+
ions and minimizes unwanted side reactions. Therefore, Zn anodes with 40% ZSO–Ga electrolyte can cycle for more than 3,000 h at 25 °C and 800 h at 50 °C. Furthermore, Zn||NH
4
V
4
O
10
(NVO) full batteries demonstrate remarkable cycle stability, lasting up to 10,000 cycles at 1 A g
−1
with a capacity retention of 79.1%. The multifunctional electrolyte additive employed in this study emerges as a promising candidate for enabling highly stable zinc anodes under diverse temperature conditions.
Enhancement of Thermoelectric Properties of Zinc Oxide Composites via Doping with Active Metal Oxide
Authors: Tang Xiaosong , Chien Sheau Wei , Zhu Qiang , Qu Zhengyao , Xu Jianwei , Wang Xizu
Published: November 2024

Active metals such as calcium (Ca)-doped zinc oxide (ZnO)-based thermoelectric (TE) materials are less studied in the literature, primarily due to the expected inherent instability caused by surface hydration. In this work, we synthesized Ca-doped ZnO-based composites (Zn

(1−
x
)

Ca

x

O) by doping ZnO with CaO nanoparticles using the spark plasma sintering method (0.05 to 0.2 mol. %) and subsequently investigated the TE properties of these Zn

(1−
x
)

Ca

x

O composites. Unlike well-known Al- or Ga-doped ZnO composites, Zn

(1−
x
)

Ca

x

O exhibited a different behavior from Al- or Ga-doped ZnO. The electrical conductivity of Zn

(1−
x
)

Ca

x

O was much improved from being nonconductive to being conductive, achieving an electrical conductivity of 650 S cm
−1
when doping with 0.1 mol. % CaO. This improvement is due to the surface hydration of hygroscopic CaO, which forms conductive Ca(OH)
2
, enhancing the electrical conductivity. However, the electrical conductivity was remarkably decreased after Zn

(1−
x
)

Ca

x

O was subjected to annealing at 860 K. In contrast, the Seebeck coefficient, ranging from −90 to −160 μV K
−1
, was not substantially affected by the high-temperature annealing process, indicating that part of Zn
2+
ions were substituted with Ca
2+
ions during annealing. Zn

(1−
x
)

Ca

x

O composites were studied by x-ray diffraction and x-ray photoelectron spectroscopy. It was found that Zn

(1−
x
)

Ca

x

O exhibited a crystal structure similar to that of ZnO. X-ray photoelectron spectroscopy results showed that there are 2 different types of Ca
2+
ions in the Zn

(1−
x
)

Ca

x

O composites. One type is assigned to Ca
2+
ions that substituted for Zn
2+
ions in the ZnO lattice, while the other type is Ca
2+
ions from nonelectrically conductive free CaO. The temperature-dependent thermal conductivity of ZnO
0.99
CaO
0.01
before and after annealing was examined, revealing that thermal conductivity decreased with an increase in temperature consistently after annealing compared to that before annealing. A highest
ZT
of ~0.043 at 723 K was obtained, which is 8 times of that of undoped ZnO. Our study demonstrates the feasibility of CaO-doped ZnO as a potential TE material.
Essential Regulation of YAP1 in Fate Determinations of Spermatogonial Stem Cells and Male Fertility by Interacting with RAD21 and Targeting NEDD4 in Humans and Mice
Authors: Li Chunyun , Chen Wei , Cui Yinghong , Zhang Dong , Yuan Qingqing , Yu Xing , He Zuping
Published: November 2024

Spermatogenesis is a sophisticated biological process by which spermatogonial stem cells (SSCs) undergo self-renewal and differentiation into spermatozoa. Molecular mechanisms underlying fate determinations of human SSCs by key genes and signaling pathways remain elusive. Here, we report for the first time that Yes1-associated transcriptional regulator (YAP1) is required for fate determinations of SSCs and male fertility by interacting with RAD21 and targeting NEDD4 in humans and mice. YAP1 was mainly located at cell nuclei of human SSCs. YAP1 silencing resulted in the decreases in proliferation and DNA synthesis as well as an enhancement in apoptosis of human SSCs both in vivo and in vitro. RNA sequencing and real-time polymerase chain reaction assays identified NEDD4 as a target of YAP1, and NEDD4 knockdown inhibited the proliferation of human SSCs and increased their apoptosis. Furthermore, YAP1 interacted with RAD21 to regulate NEDD4 transcription in human SSCs. Importantly, YAP1 abnormalities were found to be associated with non-obstructive azoospermia (NOA) as manifested as lower expression level of YAP1 in testicular tissues of NOA patients and
YAP1
single-nucleotide variants (SNVs) in 777 NOA patients. Finally,
Yap1
germline conditional knockout (cKO) mice assumed mitotic arrest, low sperm count, and motility. Collectively, these results highlight a critical role of YAP1 in determining the fate determinations of human SSCs and male infertility through the YAP1/RAD21/NEDD4 pathway. This study provides new insights into the genetic regulatory mechanisms underlying human spermatogenesis and the pathogenesis of NOA, and it offers new targets for gene therapy of male infertility.
Protein Phosphatase 2A Promotes CD8
+
T Cell Effector Function through the Augmentation of CD28 Costimulation
Authors: Zhu Kaixiang , Rohila Deepak , Zhao Yuanling , Shytikov Dmytro , Wu Lize , Zhao Fan , Hu Shurong , Xu Qin , Jin Xuexiao , Lu Linrong
Published: November 2024

Protein phosphatase 2A (PP2A) is one of the most abundant serine/threonine phosphatases and plays critical roles in regulating cell fate and function. We previously showed that PP2A regulates the differentiation of CD4
+
T cells and the development of thymocytes. Nevertheless, its role in CD8
+
T cells remains elusive. By ablating the catalytic subunit α (Cα) of PP2A in CD8
+
T cells, we revealed the essential role of PP2A in promoting the effector functions of CD8
+
T cells. Notably, PP2A Cα-deficient CD8
+
T cells exhibit reduced proliferation and decreased cytokine production upon stimulation in vitro. In vivo, mice lacking PP2A Cα in T cells displayed defective immune responses against lymphocytic choriomeningitis virus infection, associated with reduced CD8
+
T cell expansion and decreased cytokine production. Consistently, the ablation of the PP2A Cα subunit in CD8
+
T cells results in attenuated antitumor activity in mice. There is a notable decrease in the infiltration of PP2A Cα-deficient CD8
+
T cells within the tumor microenvironment, and the cells that do infiltrate exhibit diminished effector functions. Mechanistically, PP2A Cα deficiency impedes CD28-induced AKT Ser
473
phosphorylation, thus impairing CD8
+
T cell costimulation signal. Collectively, our findings underscore the critical role of phosphatase PP2A as a propeller for CD28-mediated costimulation signaling in CD8
+
T cell effector function by fine-tuning T cell activation.