bluuebunny/crossref_metadata_2025 huggingface dataset:
EFFICACY AND SAFETY OF PAIN OIL TOPICALAPPLICATION WITH MASSAGE THERAPY IN PATIENTS WITH MUSCULOSKELETAL PAIN: A RANDOMIZED CONTROLLED CLINICAL TRIAL
Authors: H. Rai Richa , Kalra Sheetal , K Jain Gaurav
Published: November 2024

Background: Musculoskeletal pain affects nearly 30% of the population globally and is characterized by functional limitation, emotional distress,
and reduced quality of life. The present study investigates the efcacy and safety of herbal pain oil application with massage in patients with
musculoskeletal pain. Methods: In this open label, randomized trial, 64 patients with musculoskeletal pain (knee, shoulder, neck, and lower back),
visited OPD of School of Physiotherapy, DPSRU were recruited. They were randomly assigned to two groups: control group treated with massage
therapy only and pain oil group treated with massage therapy with Achoo herbal pain oil. The patients were evaluated at baseline (before treatment),
during treatment at day 3, day 7 and day 15 (end of treatment) in terms of pain via visual analogue scale (VAS), application suitability via patients'
global assessment (PGA) and safety via irritation scoring. The data were statistically analyzed. Results: The mean VAS pain score was
signicantly (p < 0.05) lower in pain oil group compared to control at all the time points. The pain reduction was nearly 38% and 34% higher in pain
oil group compared to control at day 3 and 15, respectively. Compared to baseline, 44.4% to 50.9% reduction in mean VAS score was observed in all
the musculoskeletal pains. The PGA and irritation score of pain oil group was not signicantly different (p > 0.05) from control group indicating
ease of application, lack of discomfort and safety of herbal pain oil. Conclusion: Topical application of herbal pain oil with massage was effective
in relieving pain in patients with musculoskeletal pain without causing any systemic or local harm. However, multi-centric clinical studies are
required to conrm the present ndings.
CORRECTION OF GUMMY SMILE BY SURGICAL LIP REPOSITIONING: A CASE REPORT
Authors: Khan Mohd. Aamir , Lal Nand , Ismail Hira , Saxena Ayan
Published: November 2024

Excessive gingival display or gummy smile results in an unesthetic smile, which can be uncomfortable for many patients. The lip repositioning
technique has emerged as an effective way to correct excessive gingival display. For patients unwilling to undergo orthognathic surgery for
correction of mild vertical maxillary excess, this technique offers them promising results. The technique provides patients with good esthetic
outcomes.
A CASE OF WANDERING SPLEEN WITH SPLENIC INFARCTION: A RADIOLOGICAL CURIOSITY.
Authors: Biswas Pintu , Saritha Pipavath
Published: November 2024

Wandering spleen is a rare condition characterized by the displacement of the spleen from its normal anatomical position in the left upper quadrant
of the abdomen. This anomaly results from a congenital failure in the development of one or more of the intraperitoneal visceral ligaments
responsible for maintaining the spleen's position. We present a case of a pediatric patient with wandering spleen complicated by splenic infarction,
highlighting the clinical and diagnostic challenges associated with this rare condition.
Effects of Aqueous Extracts of Neem Leaf and Ginger Rhizome on Growth Performance and Haematological Parameters of Pure and Crossbred Chickens
Authors: Anizoba Nnenna Winifred , Ugwu Simeon Ogochukwu , Ndofor-Foleng Harriet Mbunwen , Onyimonyi Anselm Ego , Ikeh Nnanna Ephraim , Ezenwosu Celestine , Amaefule Bright Chigozie , Ugwu Chekwube Maureen , Nwoga Cornelius Chijiok , Udeh Fredrick Ugochukwu , Ugwuoke Jervas Ikechukwu , Madu Patricia Onyemaechi , Damian-Ozoke Regina , Chukwudi Prosper , Onuorah Samuel Ifeanyichukwu , Machebe Ndubuisi Samuel
Published: November 2024

Neem leaf and ginger rhizome contain numerous chemical components that are biologically active and are widely utilized in medications to treat various illnesses. The purpose of the current study was to assess the effect of aqueous neem leaf and ginger rhizome extracts on the growth performance and hematological parameters in the three breeds of chicken. A total of 360 one-day-old chicks from 3 genetic groups consisting of 120 Noiler chicks, 120 Heavy Ecotype chicks, and 120 main cross chicks were considered for this study. Each breed of chickens was randomly distributed into four groups, with three replications per group. Each replication consisted of eight females and two males, raised in a deep litter system. A 3×4 factorial arrangement was employed, involving four levels of plant extracts: a control group receiving the basal diet without any extract, a group receiving 200 ml of neem extract (NE200), a group receiving 200 ml of ginger extract (GE200), and a group receiving 100 ml of neem + 100 ml of ginger extract (NE100+GE100). The chickens were evaluated for growth parameters such as initial weight (IW), final weight (FW), average daily gain (ADG), average feed intake (AFI), feed conversion ratio (FCR) as well as some haematological parameters such as haemoglobin (Hb), packed cell volume (PCV), white blood cell (WBC), red blood cell (RBC), platelet (P), mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), and mean corpuscular haemoglobin concentration (MCHC). Noiler chickens receiving NE100+GE100 and GE200 showed the highest final body weight and daily weight gain. The results of the haematological indices revealed that the interaction effect of genotype and plant extracts on all the treatment groups were significantly different for haemoglobin (Hb), packed cell volume (PCV), white blood cell (WBC), and platelet (P). Some haematological indices such as Hb, PCV, WBC, and platelet were better for chickens receiving GE200 and NE100+GE100 compared to NE200 and control groups. In conclusion, the interaction of GE200 and NE100+GE100 with Noiler and main cross chickens was beneficial, with no adverse effects on the physiological traits and health status of the chickens 16 weeks of age.
Keywords: Haematology, Heavy ecotype, Heterosis, Noiler, Performance, Plant extracts
We Are on the Verge of Breakthrough Cures for Type 1 Diabetes, but Who Are the 2 Million Americans Who Have It?
Authors: Smith Rebecca , Eisenberg Samara , Turner-Phifer Aaron , LeGrand Jacqueline , Pincus Sarah , Omer Yousra , Wang Fei , Pyenson Bruce
Published: November 2024

Background: Two million Americans have type 1 diabetes (T1DM). Innovative treatments have standardized insulin delivery and improved outcomes for patients, but patients’ access to such technologies depends on social determinants of health, including insurance coverage, proper diagnosis, and appropriate patient supports. Prior estimates of US prevalence, incidence, and patient characteristics have relied on data from select regions and younger ages and miss important determinants.

Objectives: This study sought to use large, nationally representative healthcare claims data sets to holistically estimate the size of the current US population with T1DM and investigate geographic nuances in prevalence and incidence, patient demographics, insurance coverage, and device use. This work also aimed to project T1DM population growth over the next 10 years.

Methods: We used administrative claims from 4 sources to identify prevalent and incident T1DM patients in the US, as well as various demographic and insurance characteristics of the patient population. We combined this data with information from national population growth projections and literature to construct an actuarial model to project growth of the T1DM population based on current trends and scenarios for 2024, 2029, and 2033.

Results: We estimated 2.07 million T1DM patients nationally across all insurance coverages in our 2024 baseline model year: 1.79 million adults (≥20 years) and 0.28 million children. This represents a US T1DM prevalence rate of 617 per 100 000 and an incidence rate of 0.016%. By 2033, we project the US population with T1DM will grow by about 10%, reaching approximately 2.29 million patients.

Discussion: Our results showed important differences in T1DM prevalence and incidence across regions, payers, and ethnic groups. This suggests studies based on more geographically concentrated data may miss important variation in prevalence and incidence across regions. It also indicates T1DM prevalence tends to vary by income, consistent with several international studies.

Conclusions: Accurate projections of T1DM population growth are critical to ensure appropriate healthcare coverage and reimbursement for treatments. Our work supports future policy and research efforts with 2024, 2029, and 2033 projections of demographics and insurance coverage for people with T1DM.
Modelos de predicción para detectar pacientes con enfermedades cardiacas empleando redes neuronales y las bibliotecas Pytorch y TensorFlow
Authors: del Castillo Collazo Nelson , Durán Ortega Adalberto Joel , García Nocetti D. Fabián
Published: November 2024

Neural Networks are used to generate prediction models aimed at determining whether an individual has heart conditions. The PyTorch and TensorFlow libraries are applied to a dataset of patients related to heart diseases, containing 17 predictor variables. The purpose of this work is to compare the results obtained using the aforementioned libraries with Neural Networks, analyzing the behavior of loss functions and the outcomes from the confusion matrix when creating the prediction model. DownSampling and UpSampling techniques are employed to address the imbalance in the dataset, which consists of a total of 319,795 patients, of whom only 27,373 have heart disease. It was found that for this dataset, the best results with PyTorch are achieved in models of 100 epochs and above, with execution times of only a few seconds, while TensorFlow shows good results starting from models with 10 epochs, though its execution time is considerably longer. An analysis is conducted on the difference in computation time between PyTorch and TensorFlow.
Trends in female applicants to Canadian ophthalmology residency programs from 1998-2020
Authors: McDonald Heather M , Cote Stephanie L , McMillan Austin , Sharan Sapna
Published: November 2024

Background: Ophthalmology has historically been a male-dominated specialty. Despite there being a higher proportion of females in Canadian medical schools since the early 2000s, it is unknown if trends in female applicants and those accepted to ophthalmology have followed suit. This study aims to evaluate trends in gender representation of ophthalmology applicants to Canadian residency programs from 1998 to 2020 and to compare those trends to other surgical specialties.
Methods: We obtained aggregate data of the annual number of male and female applicants ranking and successfully matching to ophthalmology as their first-choice specialty from the Canadian Residency Matching Service (CaRMS) database. We then carried out a retrospective cross-sectional analysis on the publicly available data. Subsequently, we compared trends in female applicants to ophthalmology, as well as female practicing ophthalmologists, to other surgical disciplines.
Results:  The proportion of female applicants increased from 24.3% in 1998 to 33.3% in 2020 (p = 0.001), and matched female applicants increased from 28.6% in 1998 to 40.5% in 2020 (p = 0.023). However, the incremental change in proportion did not statistically significantly increase in 2008-2012, 2013-2016, and 2017-2020. Comparison of male and female matching success rates did not reveal a significant difference (p = 0.45). Trends in female applicants to ophthalmology and female practicing ophthalmologists were similar to other surgical specialties.
Conclusions: Although the proportion of female applicants is increasing, there is a recent plateau and an inability to equalize the female-to-male ratio in ophthalmology. Further studies are needed to identify potential barriers and mitigate possible residual gender biases.
Suicide prevention skills training in pre-clerkship medical students: a pilot study
Authors: Zeeman Michael , Chow Jessica , Goldstein Cheryl , Lewis Melanie
Published: November 2024

When equipped with the skills to recognize and intervene effectively, peers are well positioned to be early responders to near-peers in mental distress. This pilot study provides a framework for providing suicide prevention skills training to pre-clerkship medical students with the aim to improve early peer-to-peer detection and initial aid for mental health crises. This training is effective in improving students’ self-reported comfort to provide early intervention to peers with declining mental health. Participants felt strongly that this training merits integration into core medical education and did not identify the added courseload as a major burden. Other programs should consider adopting such an initiative.
Objectification of Women in Alhamad’s Novels: A Question of De-Humanization or Empowerment in a Post-Islamic Awakening Narrative
Authors: Alazaz Hanan Abdulaziz
Published: November 2024

This paper reviews the work of the Saudi novelist, Turki Alhamad, who published in a post-Islamic Awakening in Saudi Arabia. The paper contextualizes his writing by defining the concept of sexual objectification in various theorizations of the term including several texts that represent the discourse of the Islamic Awakening movement. His work can be perceived to be de-humanizing of women particularly during the time of its publication in the 1990s and early 2000s when the movement was popular. However, a close reading of his work suggests a multiplicity of discourses in his representation of women. His work can be empowering women taking into consideration Alhamad’s non-fictional writings that promote social change in Arab and Muslim countries. Branded as a challenge of social values at the time of its publication, his work can also be interpreted as a precursor to the social shift towards women’s empowerment that took place in Saudi Arabia in recent years.
Benchmarking machine learning missing data imputation methods in large-scale mental health survey databases
Authors: Prakash Preethi , Street Kelly , Narayanan Shrikanth , Fernandez Bridget A. , Shen Yufeng , Shu Chang
Published: November 2024

Databases tied to mental and behavioral health surveys suffer from the issue of missing data when participants skip the entire survey, which affects the data quality and sample size. These missing data patterns were investigated and the imputation performance was evaluated in Simons Foundations Powering Autism Research for Knowledge, a large-scale autism cohort consists of over 117,000 participants. Four common methods were assessed – Multiple imputation by chained equations (MICE), K-nearest neighbors (KNN), MissForest, and multiple imputation with denoising autoencoders (MIDAS). In a complete subset of 15,196 autism participants, three types of missingness patterns were simulated. We observed that MIDAS and KNN performed the best as the random missingness rate increased and when blockwise missingness was simulated. The average computational times were each 10 min for MIDAS and KNN, 35 min for MissForest, and 290 min for MICE. MIDAS and KNN both provide promising imputation performance in mental and behavioral health survey data that exhibit blockwise missingness patterns.
Rare carcinoma of the ampulla of Vater with mixed histologies: A case report
Authors: Wang Lin , Shen Pu , Bian Yanhua , Li Li , Han Zhenguo , Yang Xuejing , Qin Dongyuan , Chen Xiaosai , Zhang Zhenhua
Published: November 2024

The current case is about a 62-year-old female presented with persistent fever for 10 days and yellowing of the skin for 5 days at our outpatient clinic. Laboratory tests revealed elevated levels of total bilirubin, direct bilirubin, indirect bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and γ-glutamyl transpeptidase. Abdominal computed tomography, magnetic resonance imaging, and magnetic resonance cholangiopancreatography revealed a mass in the ampulla of Vater, as well as dilatation of the intra- and extra-hepatic bile and pancreatic ducts. The patient underwent pancreaticoduodenectomy under general anesthesia. Post-operative pathological and immunohistochemical results confirmed a tumor located in the ampulla, measuring 1.5 × 1 × 1 cm. The main component of the tumor was a moderately differentiated pancreaticobiliary adenocarcinoma (ADC), combined with squamous cell carcinoma (SCC) as well as small cell neuroendocrine carcinoma (SCNEC). The cancer tissue infiltrated the entire intestinal wall, with no invasion of microvessels, lymphatic vessels, or nerves observed. Until 46 months later, there was no tumor recurrence or distant metastasis. We present an uncommon case of ADC of the ampulla of Vater combined with SCC and SCNEC. Carcinoma of the ampulla of Vater may have mixed histological components; therefore, in cases of ampullary carcinoma, appropriate specimen collection is necessary, and further studies with more focus on histological origins are required.
Fertility model evolution: A survey on mathematical models of age-specific fertility with application to Nepalese and Malaysian data
Authors: Kumar Gaire Arjun , Bahadur Gurung Yogendra , Prasad Bhusal Tara
Published: November 2024

Fertility pattern analysis and modeling to smooth age-specific fertility rates (ASFRs) form a well-established research field that holds particular importance for Asian countries. In developed nations, ASFRs typically display a bimodal skewed fertility curve, whereas, in developing countries, they usually exhibit a unimodal skewed fertility curve that diverges from the normal one. For decades, demographic experts worldwide have been interested in creating models using deterministic and stochastic approaches to represent these fertility curves. In this regard, parametric and non-parametric models have been created, with the latter providing a better fit for ASFR data. This research investigates the evolution of fertility models aimed at smoothing ASFRs. It explores suitable alternative models for countries with fast-declining, unimodal, and skewed fertility curves of ASFRs, such as Nepal and Malaysia. Nepal’s fertility rate is transitioning from a high level toward the replacement rate (2.1) at the year 2021; meanwhile, Malaysia’s fertility rate (1.7) in the year 2021 has dropped below the replacement rate. Given the lack of a universally applicable model for ASFR pattern variation, this study proposes the Kumaraswamy log-logistic distribution as a promising model to represent the ASFRs of Nepal and Malaysia accurately. Various approaches, including the Akaike information criterion, and Bayesian information criterion, are employed to validate the fitting of the proposed model.
Involvement of adverse life events in body image distortion in a patient with eating disorders
Authors: Idini Ester , Paredes-Carreño Pamela , Navarro-Gil Mayte , Barceló-Soler Alberto , Niubó-Cuadras Marina , Garcia-Campayo Javier
Published: November 2024

Adverse life events (ALEs), particularly interpersonal ALEs and those experienced during childhood are associated with adult psychopathology. Altered eating behaviors and body image distortion (BID) have been reported in maltreated children. This study aimed to evaluate the presence of interpersonal ALEs before the age of 13 years in patients with eating disorders (ED) and clarify its relationship with BID. This observational case–control study comprised the ED group, including 79 outpatients with ED, and two control groups, including 20 outpatients with depressive disorder and 41 participants with no history of mental illness. The presence of ALEs was determined using the Traumatic Events Questionnaire. To assess BID, the contouring drawing rate scale was used, and visual BID was distinguished from non-visual BID. Data were collected and processed using Statistical Package for Social Sciences v28. All tests were two-tailed (significance level of 0.05). Patients with ED had a higher proportion of interpersonal ALEs during childhood (P = 0.065). In the ED group, patients with interpersonal ALEs during childhood overestimated their shape (P = 0.021). The non-visual BID was significantly higher in patients with childhood ALEs. In a logistic regression model, the presence of interpersonal ALEs during childhood as an independent variable predicted visual and non-visual BID in patients with ED. During the estimation of body shape, it appears that the negative emotions experienced during childhood are shifted to the body shape itself. Thus, the BID experienced is attributed more to the unresolved emotions of the maltreated individuals than to the social pressures experienced.
Rapid diagnosis of culture-negative Klebsiella pneumoniae liver abscesses by next-generation sequencing: A case series
Authors: Xing Fanfan , Deng Chaowen , Luo Zhendong , Chen Jing , Lo Simon K. F. , Lau Susanna K. P. , Woo Patrick C. Y.
Published: November 2024

Diagnosis of Klebsiella pneumoniae (Kp) pyogenic liver abscesses is usually achieved by imaging and isolation of the bacterium. However, when blood and other cultures were negative, laboratory diagnosis of Kp liver abscess may be challenging. Herein we report two patients with culture-negative Kp liver abscess with atypical presentations diagnosed by metagenomic next-generation sequencing (mNGS). For the first non-diabetic patient, computed tomography examination of the abdomen showed multiple round low-density foci with untidy margin in the liver, which mimicked hydatid cysts; while the second patient presented with acute cholecystitis/cholangitis. mNGS analysis of the blood sample from the first patient revealed 144 sequence reads of Kp; and that of the second revealed 153 sequence reads of Kp as well as other latent or non-pathogenic microorganisms. Both patients responded promptly to antibiotics treatment. mNGS is a useful tool for laboratory diagnosis of culture-negative Kp liver abscess.
A new immunomagnetic microfluidic device for characterizing EGFR mutations in circulating tumor cells from patients with non-small cell lung cancer
Authors: Ogidi Nkeiruka O. , Lind Michael J. , Greenman John
Published: November 2024

Incorporating precision oncology into cancer management has begun to improve clinical outcomes. Accurate sampling techniques that detect molecular aberrations are crucial for effective implementation. Circulating tumor cells (CTCs), derived from primary or metastatic sites and present in the blood, are proposed as useful diagnostic tools, though their use has been limited due to their rarity, especially in early-stage cancers. This study presents a novel immunomagnetic microfluidic device that efficiently isolates CTCs for analyzing epidermal growth factor receptor (EGFR) mutations in patients with non-small cell lung cancer (NSCLC). The device was designed and laser-cut from polymethylmethacrylate. Validation experiments involved spiking PC-9 cells (an established lung cancer cell line containing GLU 746-ALA 750 deletion mutations in exon 19 of the EGFR gene) into media and isolating these cells. Exons 18 – 21 of EGFR were amplified using a polymerase chain reaction to demonstrate the device’s rapid mutation detection capability. Next-generation sequencing was used to characterize these exons in a cohort of 38 NSCLC patients, successfully isolating CTCs from all. Among these patients, 30 (79%) had EGFR mutations, with exon 19 showing the highest mutation rate (87%) and exon 21 the highest point mutation rate (23%). Our device captured CTCs effectively in <1 h, enabling mutation detection. Further studies are needed to assess the prognostic significance of these mutations, but this technology has potential applications in various solid tumors.
Produções jornalísticas de comunidades afro-assentadas: experiências de jornalismo negro aquilombado em Pernambuco (1988-1994)
Authors: Cardoso Aíla Cristhie , Amaral Diego
Published: November 2024

O presente trabalho pretende discutir a noção de aquilombamento como possível dispositivo de análise do jornalismo negro no Brasil. Partindo dos conceitos afrodiaspóricos de quilombismo (Nascimento, 1985), encruzilhada (Martins, 1995, 2003; Rufino,2017; Lima, 2022, 2023 ) e do debate sobre filosofia afro-centrada em Sodré (2017), o artigo analisa quatro jornais negros de Pernambuco (Angola, Djumbay, Negração e Negritude) entre os anos de 1988 e 1994. A etapa de análise se orienta por dois vetores principais: por um lado, discutimos a importância dos vínculos dos jornais com outros atores da cultura negra, como terreiros de candomblé e movimento negro; em segundo plano, e igualmente importante, discutimos como as pautas ligadas à política, ao pensamento e à sociabilidade afro-diaspórica no Brasil se manifestam nesses jornais.
Epistemologia afirmativa da Negritude
Authors: Martins Barbosa Zilda , Dias da Silva Patricia
Published: November 2024

A proposta deste trabalho é refletir sobre o conceito de epistemologia pós ações afirmativas e nas demandas de novas metodologias, daí decorrentes, que deem conta das subjetividades dos corpos negros. Problematiza a grade curricular acadêmica tradicional, fundamentada em autores/conceitos ocidentais, apagando outras produções de conhecimento. Como viabilizar a coexistência de saberes, reconhecendo as.os intelectuais negras.os como sujeitos históricos, portadores de vivências e sabedorias ancestrais? O objetivo é propor o debate coletivo e a urgência de uma nova epistemologia, numa perspectiva hermenêutica com foco na experiência ontológica do ser sujeito afro-indígena, suas ancestralidades e singularidades no mundo da vida. Tencionamos a construção de um moderno ethos acadêmico, ancorado no comum (SODRÉ, 2014).
Resenha: Como ser um Educador Antirracista
Authors: Fernandes Costa Patricia
Published: November 2024

O livro “Como ser um Educador Antirracista” foi escrito por Bárbara Carine, uma intelectual negra, palestrante, escritora, professora do Departamento de Química da UFBA e idealizadora/ sócio-fundadora da primeira escola Afro-brasileira, A Escola Maria Felipa situada na Bahia e com breve expansão para o Rio de Janeiro; tem prefácio da intelectual negra Nilma Lino Gomes, convida a sociedade a refletir e reestruturar suas práticas educacionais acerca do antirracismo ao relatar experiências de sua escola provocando um diálogo profundo.
APPLICATION OF MILITARY LAW TOWARDS TNI MEMBERS IN CASES OF CRIMINAL ACT OF INSUBORDINATION AT DILMILTI II JAKARTA
Authors: Setiawan Dimas Bagas , Sudarto Sudarto
Published: November 2024

Insubordination is an act that is completely unacceptable in the military, because it is considered to have violated the Sapta Marga and the Soldier's Oath which are the basic reference for personality patterns as TNI soldiers. Acts against superiors should not be carried out in the military environment, because acts against superiors or insubordination are classified as serious crimes. For this reason, we will further examine the absolute competence of the High Military Court in handling Insubordination Crime Cases and how military law is applied to TNI members in cases of insubordination crimes at the Jakarta II High Military Court. The research method used in this research is a normative legal research method. From the research results it was found that the High Military Court is a Second Level Military Court which has the authority to hear appeals from First Level Military Court Decisions. Then the application of military law to members of the TNI in cases of criminal acts of insubordination at the Jakarta II High Military Court is basically the same as the First Level Military Court, namely based on the Military Criminal Code (KUHPM). The results of the DILMILTI decision can be different from those of the Military Court of First Instance due to differences in the opinions of the panel of judges, but can also have the same results because of the similarities in the analysis and opinions of the Panel of Judges so that the new decision actually strengthens the previous decision.
Analisis Faktor yang Mempengaruhi Persalinan Induksi di Rumah Sakit Citra Sari Husada Karawang
Authors: Jusmawati  , Sukmawati
Published: November 2024

Induksi persalinan adalah suatu usaha untuk memulai persalinan sebelum atau sesudah kehamilan cukup bulan dengan cara merangsang (stimulasi) permulaan kehamilan. Untuk mengetahui hasil analisis faktor-faktor yang mempengaruhi induksi persalinan di RS Citra Sari Husada Kecamatan Kelari Kabupaten Karawang. Penelitian ini menggunakan metode kuantitatif deskriptif korelasional dengan pengambilan sampel purposive dengan jumlah sampel 23 orang. Teknik datanya meliputi analisis uivariat menggunakan distribusi frekuensi dan analisis bivariat menggunakan perhitungan statistik menggunakan program SPSS. Hasil analisis menunjukkan adanya hubungan yang signifikan antara kehamilan lewat waktu dengan induksi persalinan, dengan nilai signifikansi yang konsisten dibawah 0,05, walaupun perlu mempertimbangkan keterbatasan dan catatan tersebut, hasil penelitian ini secara umum mendukung pengaruh kehamilan lewat bulan. kehamilan terhadap kecenderungan induksi persalinan yaitu 78,5% menjalani induksi persalinan.  Penelitian ini menunjukkan bahwa faktor-faktor seperti Ketuban Pecah Dini (PROM), Kehamilan Terlambat, dan Hipertensi mempunyai pengaruh yang signifikan terhadap keputusan induksi persalinan di RS Citra Sari Husada.
Efektivitas Daun Katuk Terhadap Peningkatan Produksi ASI
Authors: Farlikhatun Lili , Novita
Published: November 2024

Cakupan ASI eksklusif di Kecamatan Cilebar Kabupaten Karawang  termasuk di PMB N pada tahun 2022 sebesar 11,64%, meskipun pada tahun 2023 mengalami peningkatan menjadi  12,71% akan tetapi capaian tersebut belum memenuhi capaian target pada bayi usia 6 bulan mendapat ASI eksklusif adalah 45% di tahun 2020 sehingga perlu adanya upaya untuk meningkatkan pencapian ASI eksklusif di Kecamatan Cilebar. Rendahnya cakupan ASI Eksklusif dapat ditimbulkan oleh berbagai macam faktor, salah satunya adalah faktor produksi ASI yang tidak maksimal. Pemberian ASI Eksklusif di tempat penelitian masih sangat rendah dapat menimbulkan masalah gizi pada balita. Upaya untuk menanggulanginya antara lain dengan meningkatkan dan kualitas ASI. Banyak cara yang dapat dilakukan untuk memperlancar ASI diantaranya konsumsi daun katuk karena adanya kandungan yang dapat meningkatkan produksi ASI.  Tujuan Penulisaan : Mengetahui efektivitas daun katuk terhadap peningkatan produksi ASI di PMB N Desa Pusakajaya Selatan Kecamatan Cilebar Kabupaten Karawang tahun 2020. Metode Penelitian : Quasy Eksperiment dengan desain one group pretest-posttest design. Sampel adalah ibu postpartum hari ke-4 pasca melahirkan yang mengalami produksi ASI kurang sebanyak 48 sampel dengan teknik accidental sampling. Analisis bivariat menggunakan uji paired simple t test. Hasil Penelitian : Hasil penelitian univariat  produksi ASI sebelum pemberian daun katuk seluruhnya sedikit sebanyak 100%. Produksi ASI sesudah pemberian daun katuk sebagian besar cukup sebanyak 81,3%. Hasil penelitian bivariat didapatkan nilai p value = 0,000.  Kesimpulan dan Saran : Ada efektivitas pemberian daun katuk terhadap peningkatan produksi ASI. Diharapkan ibu menyusui dapat mengkonsumsi olahan daun katuk secara rutin selama menyusui agar dapat meningkatkan produksi ASI sehingga bayi ibu mendapatkan ASI eksklusif.
Guru PAK Sebagai Teladan Melalui Kebijaksanaan Verbal Berdasarkan Yakobus 3:1-10
Authors: Saguntung Rinta Lozani , Saogo Soneta Veronica , Maradita Yolanda , Hasibuan Nelson
Published: November 2024

Lidah manusia memiliki kekuatan yang sangat besar dalam mempengaruhi orang lain, baik secara positif maupun negatif. Meskipun kecil, lidah dapat menjadi senjata yang sangat berbahaya jika digunakan dengan tidak bijaksana. Pernyataan ini sama dengan ulasan dari Yakobus 3: 1-10.  Tujuan dari tulisan ini adalah menekankan pentingnya  kontrol diri dalam praktik berbicara,terutama dalam konteks pendidikan yang di pelopori oleh Guru. Peran guru sangat penting dalam membentuk mental dan percaya diri peserta didik melalui verbal. Tulisan ini bersifat kualitatif dengan menggunakan pendekatan studi literatur terhadap fenomena guru sebagai teladan melalui perkataan sesuai dengan teks Alkitab yakni Yakobus 3: 1-10. Hasil dari tulisan ini diuraikan dalam empat poin yakni pertama, Guru PAK harus mampu menjadi komunikator yang baik. Kedua, kepribadian Guru PAK sangat menentukan dinamika pembelajaran agama Kristen. Ketiga, Yakobus 3: 1-10 merupakan pengingat bagi guru PAK untuk menjaga lidahnya. Keempat, dari analisis pada Yakobus 3: 1-10, kita menemukan strategi guru PAK sebagai teladan melalui praktik verbalnya. Dengan demikian, guru PAK tidak boleh hanya berbicara tentang nilai-nilai Kristen tetapi juga mengamalkannya dalam kehidupan sehari-hari.
Imajinasi Poskolonial dan Interdependensi Pembebasan dalam Upaya Pendidikan Agama Kristen yang Interreligius-Interkultural di Indonesia
Authors: Lauterboom Mariska
Published: November 2024

Abstract Tolerance should be a two-way communication between different groups in society, not just from the minority to the majority. Interreligious and intercultural religious education can contribute significantly to the deep tolerance of Indonesian society. This paper identifies and analyzes the potential collaboration between postcolonial imagination and liberating interdependence in interreligious-intercultural Christian religious education, using qualitative research based on a literature study with postcolonial analysis supported by interviews with five Christian religious leaders in Indonesia. Postcolonial imagination and liberating interdependence result in interreligious and intercultural education that promotes dialogue, liberation, tolerance, and social justice in Indonesia’s pluralistic context. This educational approach will widen the learning space so that it is not limited to the classroom or church walls only. A safe learning space will be created for various local narratives in their encounters with diverse religious stories and their connection to economic structure, politics, race, and gender.  This learning space also allows both women and men to share their life stories in connection to God the Liberator.  Keywords: Education, Interreligious, Intercultural, Postcolonial Imagination, Interdependence.
,,stellt euch vor“. Artenvielfalt und Artensterben bei Jan Wagner. (,,franz de hamilton: konzert der vögel“ und ,,das verschwinden des riesenalks“)
Authors: van Hoorn Tanja
Published: November 2024

Abstract Artenvielfalt gestaltet Jan Wagner als ein ekphrastisch inspiriertes Heraufbeschwören schöner Mannigfaltigkeit (,,franz de hamilton: konzert der vögel“); Artensterben als das Verschwinden eines Endlings im Abendrot (,,das verschwinden
des riesenalks“). In beiden Gedichten sind Tiere nur (noch) imaginär erreichbar und werden betont anthropozentrisch dargestellt. Die Gedichte unterscheiden sich hinsichtlich zentraler Darstellungsverfahren (katalogartige Parataxen für die Vielfalt, Narration eines Artschicksals
im Fall des Aussterbens); gleichermaßen aber wird in ihnen das Lynchen eines Vogels bzw. der zum Erlöschen einer ganzen Art führende Massenmord gespiegelt in der abergläubischen Ideologiebildung der Menschen. Kaum zufällig scheinen die beiden Gedichte daher in den
inhaltlich und rhythmisch ähnlichen Abschlussformeln (,,ein pamphlet“ / ,,ein gerücht“) echoartig aufeinander zu antworten.
Versifizierung als Diversifizierung. Arno Holz Phantasus und die Naturformen der Lyrik*
Authors: Friedrich Lars
Published: November 2024

Abstract Auf der Grundlage eines positivistischen Wissenschaftsverständnisses entwickelt Arno Holz Ende des 19. Jahrhunderts eine Lyriktheorie ,natürlicher Rhythmen‘, die auf Metrum, Strophen und Reim verzichten und deren unregelmäßige Versstruktur
in seinem Phantasus-Zyklus ihre poetische Umsetzung erfahren. An den Umarbeitungsstufen bzw. Erweiterungsstrategien einzelner Phantasus-Gedichte wird gezeigt, wie Holz Erfahrungen entgrenzter Natur- und Sprachvielfalt abzubilden versucht und seine Lyrik formpoetologisch als Applikation
einer Diversitätsprogrammatik gelesen werden kann.
Evaluation of continued 2-monthly or annual urate monitoring in gout: an extension of the GoutSMART randomised controlled feasibility trial
Authors: Riches Philip L. , Alexander Debbie , Brown Clare , Abbas Hawazin , Hart Rowan , Krause Amrey
Published: November 2024

Aim: Improved outcomes for patients with gout are associated with reduced urate levels and many guidelines recommend regular urate monitoring. There is no consensus on how frequently monitoring should be performed, and so we have used a supported self-management approach which incorporates urate self-testing to evaluate 2-monthly urate monitoring compared to annual monitoring. Methods: This study was an extension of a 12-month feasibility trial in 60 gout patients randomised 2:1 to support gout self-management or usual care. Participants exiting the self-management arm were offered 2-monthly urate monitoring, with usual care participants offered annual monitoring. Additional participants were randomised 1:1 to either arm. All participants were offered initial dose titration to a urate target of 0.3 mmol/L. The primary outcome was the proportion of participants with urate ≤ 0.36 mmol/L at 24 months with an intention-to-treat analysis. Results: Between September 2020, and September 2021, 67 patients were enrolled. The mean age was 55.5 (SD 14.0) years. 61 (91%) self-reported as cisgender male, 5 (7.5%) as cisgender female and 1 (1.5%) as transgender female. 62 (92.5%) were White, 4 (6.0%) were Asian and 1 (1.5%) was Black. 40 participants were allocated to 2-monthly monitoring (including 10 new participants), and 27 participants to annual monitoring (including 12 new participants). The primary study outcome of urate ≤ 0.36 mmol/L at 24 months was achieved by 38 (95%) 2-monthly monitoring participants, compared to 17 (62.9%) annual monitoring participants (risk difference 0.32 [95% CI 0.13 to 0.52]; p = 0.0021). 5 (7.5%) participants withdrew with 4 allocated to annual monitoring. 2 annual monitoring participants died. Conclusions: 2-monthly monitoring of urate is associated with improved maintenance of urate targets after 2 years compared to annual monitoring, a result influenced by an increased withdrawal rate amongst annual monitoring participants. Further trials evaluating the cost-effectiveness and optimal frequency of urate monitoring are now needed (ClinicalTrials.gov identifier: NCT03274063).
Tránsitos, intersticios y experiencia fronteriza: Lo inframundano en Señales que precederán al fin del mundo, de Yuri Herrera
Authors: Ríos Baeza Felipe Adrián
Published: November 2024

Este ensayo propone una lectura de la novela Señales que precederán al fin del mundo (2009), del escritor mexicano Yuri Herrera (Actopan, Hidalgo, 1970), ampliando la perspectiva que la crítica especializada ha marcado hasta el momento. Esta pone el acento en la violencia desatada en el sexenio 2006-2012 y la semejanza de la historia de Makina, su protagonista, con el viaje al Mictlán, la región de los muertos en la cosmogonía mexica. Recuperando algunas nociones sobre la liminalidad en el pensamiento, la literatura y la experiencia de los países “posoccidentalizados” (Homi K. Bhabha, Walter Mignolo, entre otros), este trabajo analizará el paso que hace el personaje de México a Estados Unidos, no solo como reconocimiento de dichas temáticas, sino por un valor literario que radica en los intersticios. Dicho fenómeno puede evidenciarse tanto en los territorios que Makina recorre como en los diálogos que establece con los demás personajes. De esta manera, el concepto de lo “inframundano” cobrará otro significado en la novela, más como umbral transformador que como lugar de condena o destino.
“La poesía de Ángeles Mora. Otra manera de mirar el mundo”, de José Jurado Morales (ed.)
Authors: Baños Saldaña José Ángel
Published: November 2024

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Perspectives de personnes enseignantes et éducatrices qui œuvrent en éducation à l’environnement et au développement durable (EEDD) : quelles pistes pour leur développement professionnel ?
Authors: Therriault Geneviève , Jeziorski Agnieszka , Morin Émilie , Simard Catherine , Araújo-Oliveira Anderson , Charland Patrick , Gicquel Andréa , D'Or Auryane , Roubert Émilie , Renaud Christian
Published: November 2024

L’article présente les résultats d’une recherche exploratoire à devis méthodologique mixte dont l’objectif est d’explorer les perspectives des personnes enseignantes et éducatrices des milieux d’éducation formels (écoles primaires et secondaires) et non formels (organismes, associations, parcs, musées, centres d’interprétation de la nature) au regard de trois concepts importants en éducation à l’environnement et au développement durable (EEDD) : le rapport aux savoirs, les pratiques éducatives et l’agentivité écocitoyenne. Les points de vue des acteurs et actrices clés ont été recueillis par l’entremise d’un questionnaire comportant des questions ouvertes et fermées. Les données ont été collectées à la fois en France et au Québec auprès de 356 répondantes et répondants. Les résultats obtenus se rapportent à la fois aux rapports aux savoirs environnementaux et liés au développement durable (DD), aux principales activités ou interventions en EEDD, et aux niveaux et aux types d’engagement déclarés. Les analyses effectuées témoignent de différences significatives entre les groupes à l’étude et pointent vers plusieurs pistes permettant de soutenir le développement professionnel des personnes enseignantes et éducatrices en cette matière.
Formation, accompagnement pédagogique et développement professionnel des professeur·es d'université : étude de cas multiples à Bahia, Brésil et au Québec, Canada
Authors: D’Ávila Cristina
Published: November 2024

L'attention portée à la formation, à l’accompagnement pédagogique et au développement professionnel du corps professoral universitaire demeure une préoccupation incontournable. Au Brésil, comme ailleurs, un nombre significatif de ces professionnel·les entament leur carrière sans bénéficier d'une formation pédagogique adéquate. Ils sont bachelier·ères, technicien·nes ou docteur·es, spécialisés dans leur domaine disciplinaire, mais dépourvus d'une préparation pédagogique. Pour relever ce défi, des centres de soutien et d'accompagnement pédagogiques ont été instaurés au Québec et au Brésil. Dans ce contexte, notre recherche vise à décrire, analyser et comprendre le rôle des centres de pédagogie universitaire à l'Université fédérale de Bahia (UFBA) et à l'Université de Montréal (UdeM) dans la formation et le développement professionnels des professeur·es. Notre approche repose sur une étude de cas multiples, adoptant une perspective qualitative. La collecte de données combine des entretiens semi-structurés avec des professeur·es, des coordonnateur·trices et des conseiller·ères pédagogiques ayant participé aux deux initiatives, ainsi qu'une analyse de l'infrastructure et des projets pédagogiques respectifs.
Sokratik Sorgulamanın Sanık (Terör Suçlulularında) Sorgusunda Kullanılması
Authors: Özen Yener
Published: November 2024

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Nanotechnological approaches for efficient N2B delivery: from small-molecule drugs to biopharmaceuticals
Authors: Akpinar Adscheid Selin , Türeli Akif Emre , Günday-Türeli Nazende , Schneider Marc
Published: November 2024

Central nervous system diseases negatively affect patients and society. Providing successful noninvasive treatments for these diseases is challenging because of the presence of the blood–brain barrier. While protecting the brain’s homeostasis, the barrier limits the passage of almost all large-molecule drugs and most small-molecule drugs. A noninvasive method, nose-to-brain delivery (N2B delivery) has been proposed to overcome this challenge. By exploiting the direct anatomical interaction between the nose and the brain, the drugs can reach the target, the brain. Moreover, the drugs can be encapsulated into various drug delivery systems to enhance physicochemical characteristics and targeting success. Many preclinical data show that this strategy can effectively deliver biopharmaceuticals to the brain. Therefore, this review focuses on N2B delivery while giving examples of different drug delivery systems suitable for the applications. In addition, we emphasize the importance of the effective delivery of monoclonal antibodies and RNA and stress the recent literature tackling this challenge. While giving examples of nanotechnological approaches for the effective delivery of small or large molecules from the current literature, we highlight the preclinical studies and their results to prove the strategies’ success and limitations.
O IMPACTO DE ATIVIDADES EXTENSIONISTAS NA DIVULGAÇÃO DO CURSO DE ENGENHARIA DE BIOPROCESSOS E BIOTECNOLOGIA
Authors: Sovinski Lincon , AZEVEDO PINHEIRO CLEITON DE , Zamin Servat Eduarda , do Rosário Silva de Sousa Maria Fernanda , Regina Duarte Elis
Published: November 2024

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Pengaruh Green Product, Green Packaging dan Green Promotion Terhadap Purchase Decision Pada Produk Sensatia Botanical Bali
Authors: Suarnitha Ni Putu Early Pradnya , Antari Ni Putu Bayu Widhi , Ayu Mirayani Pradnyadari Ni Luh Made
Published: November 2024

Perubahan iklim, seperti pemanasan global, dan permasalahan pencemaran lingkungan yang disebabkan oleh pencemaran udara akibat kegiatan industri dan pencemaran air akibat bahan kimia, merupakan permasalahan utama yang menyebabkan kerusakan dan pencemaran lingkungan. Penelitian ini mencakup tiga variabel independen yaitu Green Product (X1), Green Packaging (X2), dan Green Promotion (X3), serta satu variabel dependen yaitu Keputusan Pembelian (Y). Prosedur pengumpulan data dalam penelitian ini menggunakan kuesioner dan observasi, serta menggunakan skala Likert untuk pengukurannya. Demografi yang diteliti dalam penelitian ini adalah 80 responden yang pernah menggunakan produk dari Sensatia Botanicals. Hasil penelitian menunjukkan bahwa secara parsial Green Product (X1), Green Packaging (X2), dan Green Promotion (X3) mempunyai pengaruh terhadap keputusan pembelian. Selain itu secara simultan ketiga variabel independen yaitu Green Product (X1), Green Packaging (X2), dan Green Promotion (X3) juga mempunyai pengaruh secara bersama-sama terhadap keputusan pembelian di Sensatia Botanicals.
Ciclos econômicos, salário real e qualidade dos fluxos entre empregos
Authors: Rocha Leandro Pereira da , Machado Danielle Carusi , Corseuil Carlos Henrique Leite
Published: November 2024

Analisam a flexibilidade dos salários reais no Brasil em relação ao ciclo econômico. Utilizando dados da PNAD Contínua, os autores criaram medidas diretas para classificar ocupações, permitindo controlar a qualidade dos empregos ao examinar os fluxos de trabalhadores entre eles. Os resultados mostram que os salários reagem significativamente às flutuações no ciclo econômico e que essa sensibilidade supostamente é maior para trabalhadores recém-contratados do que para os que mantêm seus empregos. Para o Brasil, essa aparente maior sensibilidade parece estar associada a uma correlação entre o ciclo econômico e a probabilidade de os trabalhadores migrarem para postos de trabalho “melhores”, cujos salários tendem a ser maiores.