bluuebunny/crossref_metadata_2025 huggingface dataset:
Pediatric musculoskeletal assessment using two screening tools: the early arthritis diagnostic questionnaire (EAD) and the pGALS (pediatric gait, legs, arms and spine)
Authors: Fonseca Bárbara , Magalhães Claudia , Corrente José
Published: April 2022

INTRODUCTION: There are limitations in the teaching and training of the musculoskeletal exam for the general practitioner, but two screening tools have become available in recent years. OBJECTIVES: Evaluate feasibility and concordance of two musculoskeletal screening tools, the 12-item questionnaire for early arthritis detection of (DPA-12) and the musculoskeletal examination pGALS (pediatric, gait, arms, legs and spine), in the same patient, during the routine practice. METHODS: Participants between 5 and 18 years of age were examined by a trained resident, performing pGALS maneuvers and applying DPA-12 for parents. The diagnoses, descriptive analysis and scores were analyzed, categorizing the pGALS maneuvers as normal or abnormal and DPA-12 scores greater or lower than six. The internal consistency was calculated by Cronbach alpha coefficient and the correlation between categorical measures by kappa statistics. RESULTS: Sixtyseven participants were included, 40 (59.7%) were boys. Forty (59.7%) had at least one abnormal pGALS manoeuver. The diagnoses were classified as musculoskeletal (juvenile idiopathic arthritis and connective tissue diseases, flat feet, hypermobility syndrome, mechanical limb pain) and nonmusculoskeletal (cellulitis and constipation). There were 65 valid questionnaires, 21 (32.3%) scored greater or ecqual to 6, indicating higher probability of musculoskeletal diagnoses. The internal consistency scoreswere 0.79 and 0.87, respectively. The comparison of normal and abnormal variables results, resulted in low agreement by the Cohen kappa coefficient (0.31). CONCLUSION: The application of both tools in the same patients performed well, showing simplicity and feasibility, for identifying functional or structural abnormalities, regardless of the diagnosis. In practice, both tools may be useful and complementary for screening.
Case report: ring chromosome 15 syndrome and esophageal atresia
Authors: Buoniconti Caroline , Rezende Lorena , Arruda Julia , Silva Isabela , Mendoza Leonor , Cheng Isabela
Published: April 2022

Ring Chromosome 15 Syndrome is a rare neuploidy with variable phenotype in which the definitive diagnosis is made through karyotype and can be complemented with molecular methods to more accurately identify the telomere break point. There is no specific treatment, only clinical support or treatment targeting the correlated malformations. This work consists of a case report of a newborn with early diagnosis based on initial clinical alterations and imaging and karyotype tests. We describe the assessment, diagnostic confirmation, and clinical and surgical management of the patient, as well as a review of the literature.
What are medical ethics, research ethics and clinical bioethics committees?
Authors: Alves Rosana , Tavares Eduardo , Falanghe Paulo , Iglesias Simone
Published: April 2022

INTRODUCTION: Health professionals, in their daily practice, from time to time, face ethical dilemmas and doubts about the functions of committees and commissions governed by ethics and bioethics. It is imperative to clarify the attributions of these instances, in order to contribute to the practice of care and medical research. OBJECTIVES: This document aims to address in a practical way the characteristics and peculiarities of the Medical Ethics Committees, Research Ethics Committees and Clinical Bioethics, clarifying the functioning, the attributions, the objectives and the responsibilities of each of them. DISCUSSION: The Medical Ethics Committees monitor the ethical problems of the hospital, based on the verification of medical facts that have occurred and promoting preventive attitudes. Research Ethics Committees ensure the dignity, rights, safety and well-being of scientific research participants, and support the needs of researchers, promoting the discussion of ethical and legal aspects of research involving human beings. The Clinical Bioethics Commissions or Committees discuss and deliberate on the various conflicting aspects that involve activities related to mans life. CONCLUSION: Ethics, considered a human construction, is taken care of in the scope of these commissions, guaranteeing the proper conduct of the processes, with protection and trust between the individuals involved.
THE INFLUENCE OF COMPETENCE, WORK MOTIVATION AND CAREER DEVELOPMENT ON EMPLOYEE PERFORMANCE WITH ORGANIZATIONAL COMMITMENT AS A MODERATING VARIABLE IN THE MILLENNIAL GENERATION IN THE DKI JAKARTA REGION
Authors: Prasetio Muhammad Iqbal , Hasanah Hasanah
Published: April 2022

Employee performance in the Millennial Generation in the DKI Jakarta Region is experiencing problems. Problems in this performance are associated with several constructs such as competence, work motivation, career development and organizational commitment of DKI Jakarta Millennial Employees. The purpose of this study was to determine the significance of the effect of competence, work motivation and career development on employee performance, with organizational commitment as a moderating variable in the Millennial Generation in the DKI Jakarta Region. Research data obtained from the distribution of questionnaires, which will then be processed through data processing methods with SPSS version 23.0. The sample in this study amounted to 245 people using the proportional stratified random sampling method. The results of the study stated that 1) Competence had a positive and significant effect on organizational commitment, 2) Work Motivation had a positive and significant effect on organizational commitment, 3) Career Development had a positive and significant effect on organizational commitment, 4) Competence had a positive and significant effect on performance, 5 ) Work motivation has a positive and significant effect on performance, 6) Career development has no and no significant effect on performance, 7) Organizational Commitment has a positive and significant effect on performance.
ANALYSIS OF THE EFFECT OF INFLATION AND EXCHANGE RATE ON EXPORTS IN 5-YEAR ASEAN COUNTRIES (YEARS 2010–2020)
Authors: Ilmas Naptania , Amelia Mia , Risandi Rafli
Published: April 2022

International trade is a form of economic cooperation between two or more countries that provides direct benefits. International trade has an important role because a country cannot meet all domestic needs and with international trade, every country in the world can exchange resources owned by each country, with the aim that there is no excess or lack of resources in each country in the world. This research was conducted in 5 countries in ASEAN, namely Indonesia, Singapore, Thailand, Malaysia, and the Philippines with a period being tested for 11 years starting from 2010 to 2020 with 2 independent variables being tested, namely inflation and the exchange rate in 5 ASEAN countries and the dependent variable tested is Exports in the 5 ASEAN countries. Analysis of the data used in this study is panel data regression. The results of this analysis show that inflation and exchange rates have a negative and significant effect on exports in the five ASEAN countries, which means that if inflation or the exchange rate in a country increase, exports will decrease and vice versa. So, the macroeconomic factors that exist in a country must still be considered and also considered in international trade activities.
Human Development Index Analysis with Islamic Human Development Index (IHDI) Approach in DKI Jakarta in 2010-2019
Authors: Abdul Rahim Zaeni , Sofyan Syofriza , Esya Lavlimatria
Published: April 2022

The research aim is to analyze human development based on the Islamic Human Development Index (IHDI) perspective in the Special Region of Jakarta. The measuring instrument used by IHDI in this research is Maqashid Sharia which has five fundamental elements such as, Hifdzud Dien, Hifdzun Nafs, Hifdzul Maal, Hifdzul 'Aql, and Hifdzun Nashl. The five elements of this Maqashid Sharia are then measured with determining indicators and 13 indicators being analyzed. The method used in this research is the Fixed Effect Model regression method. For data processing, this research utilizes E-Views 10 software. The data used in this research is secondary data obtained from Statistic Indonesia, Ministry of Religious Affairs Indonesia, and Baznas DKI year 2010-2019. The outcome of this research is that based on Fixed Effect Model regression testing there are impacts between Hifdzud Dien, Hifdzun Nafs, Hifdzul 'Aql, Hifdzun Nashl, and Hifdzu Maal with human development index (HDI) in DKI Jakarta in 2010-2019. The implication from this research is that the five variables with 13 indicators analyzed, generally has significant implication towards HDI, especially Hifdzu Aql variable which is represented by the average length of school and the portion of the education budget. For that reason, the government should be able to encourage human development with an IHDI perspective. The most important things are improving the quality of education and education budget for citizens, besides encourage the citizen to obey religious values, such as doing zakat, avoiding criminal things and e.tc, which significantly affect human development in DKI Jakarta.
From Idea Cults to Clinical Chameleons: Moving Physical Therapists' Professional Identity Beyond Interventions
Authors: Peterson Seth R. , Erb Matt , Davenport Todd E.
Published: April 2022

Synopsis

The components of clinical practice are complex, often ambiguous, and influenced by a wide variety of interrelated contextual factors. As appreciation grows for the impact of individuality, complexity, and uncertainty in health processes, effective translation into widespread clinical practice remains limited. In attempts to bring patients effective solutions, well-meaning physical therapists can get trapped in “idea cults,” in which a favored idea is supported and others are disparaged. We recommend that physical therapists develop a practice of self-reflection marked by openness and humility to more successfully adapt to the unique needs, values, and preferences of each person. We highlight 4 ways physical therapists can cultivate a more mindful and adaptable clinical approach that can help recognize and navigate the complexities of everyday clinical practice. J Orthop Sports Phys Ther 2022;52(4):170–174. doi:10.2519/jospt.2022.10976
Pain Science in Practice: What Is Pain Neuroscience? Part 2
Authors: Hoegh Morten
Published: April 2022

Synopsis

Biomechanical explanations for musculoskeletal pain are abundant and have been used for many years; however, researchers and clinicians are moving toward neuroscience-based explanations to study and explain them. This article discusses some specific mechanisms, commonly used in pain medicine, and their somewhat less specific but equally important role in nonpharmacological management of musculoskeletal pain. The article also explains the role of different receptors and how they relate to clinical conditions. J Orthop Sports Phys Ther 2022;52(4):166–168. doi:10.2519/jospt.2022.10994
Edith Holmes Met the Challenges to Lead JOSPT to the Next Level
Authors: Beattie Paul F. , Greathouse David G.
Published: April 2022

Synopsis

After 19 years at the helm, we are privileged to honor Ms. Edith Holmes upon her retirement as Executive Director/Publisher of JOSPT. Ms. Holmes set the standard by integrating and communicating effectively with a diverse group of stakeholders. Ms. Holmes is honored for her superb work, inspiration, and commitment to JOSPT. J Orthop Sports Phys Ther 2022;52(4):169. doi:10.2519/jospt.2022.11258
DIREITOS DA PERSONALIDADE DO EMPREGADO COMO LIMITES AO PODER EMPREGATÍCIO DE DEFINIR E IMPOR O USO DE UNIFORMES, ITENS DE IDENTIFICAÇÃO E LOGOMARCAS EMPRESARIAIS
Authors: Goldschmidt Rodrigo , Espiúca dos Anjos Siqueira Rodrigo
Published: April 2022

A pesquisa analisa o exercício do poder empregatício disposto no art. 456-A da CLT, com a redação da Lei 13.467/2017, que autoriza ao empregador impor aos empregados o uso do padrão do uniforme que contenha outros identificadores e logomarcas empresariais. As questões que se apresentam são: Quais são as implicações desse novo poder empregatício? Quais as limitações normativas ao seu exercício? Para responder às perguntas, o texto subdivide-se em quatro partes. A primeira é dedicada a analisar os poderes do empregador. A seguir, investiga-se o art. 456-A, da CLT, em sua extensão e conteúdo. A terceira seção analisa a questão dos direitos da personalidade, dentro do marco legal constitucional e infraconstitucional, e sua aplicação à relação de emprego. Por seu turno, a quarta, e última, seção estuda a aplicação dos direitos da personalidade como limite/baliza para o exercício do poder patronal constante no art. 456-A, da CLT. A hipótese da pesquisa é a de que esse novo poder empregatício submete-se à limites e parâmetros definidos pelo regime de direitos da personalidade do empregado. Por método, adotou-se o dedutivo, organizado pelo viés metodológico monográfico, com a aplicação da técnica de pesquisa bibliográfica e documental.
A PROTEÇÃO DE DADOS SENSÍVEIS NO SISTEMA NORMATIVO BRASILEIRO SOB O ENFOQUE DA LEI GERAL DE PROTEÇÃO DE DADOS (LGPD) – L. 13.709/2018
Authors: Sales Sarlet Gabrielle Bezerra , Linden Ruaro Regina
Published: April 2022

Consiste em pesquisa bibliográfica e exploratória acerca dos institutos do ordenamento brasileiro que tocam à proteção de dados pessoais, especificamente ancorada na Lei Geral de Proteção de dados(LGPD), voltando-se para os dados sensíveis em razão do seu potencial discriminatório e, nesse sentido, para o reconhecimento de um direito fundamental ao tratamento apropriado das informações imprescindíveis para a estruturação, para a proteção da identidade e para o livre desenvolvimento da personalidade da pessoa humana no contexto informacional tendo em vista a preservação do regime democrático.
Aspectos nutricionais e psicológicos de idosos não intitucionalizados
Authors: Bortoluzzi Patricia , Amaro Catylin , Emanuela Chaud Hallvass Andrea
Published: April 2022

O aumento da expectativa de vida dos idosos é uma realidade que vem crescendo a cada dia, e com isso as doenças que surgem com o avanço da idade podem refletir diretamente na qualidade de vida dos mesmos. O que se tem observado é que hábitos nutricionais adequados afetam diretamente a saúde e a qualidade de vida dos indivíduos em qualquer idade. O presente estudo teve como objetivo fazer uma análise quantitativa observacional com intuito de avaliar o estado nutricional e psicológico de idosos não institucionalizados e a relação entre esses fatores. Para isso foram selecionados 20 idosos de ambos os sexos da região de Curitiba-PR, que foram submetidos à Mini Avaliação Nutricional (MAN) e ao questionário de Escala de Depressão Geriátrica (GDS). Para análise de dados foram utilizados o Teste T de Student e o Teste Exato de Fisher. Foi encontrado uma prevalência maior de depressão em idosos divorciados/solteiros e viúvos. De acordo com o  (IMC) 13 (65%) dos idosos foram classificados com sobrepeso, em avaliação da MAN 14 (70%) dos indivíduos não apresentaram nenhum risco de desnutrição e 6 (30%) apresentaram risco de desnutrição. Não houve relação estatisticamente significativa entre os índices de depressão e estado nutricional nos indivíduos. Conclui-se que a partir do achados desse estudo não foi observada uma relação significativa entre o estado nutricional e estado mental dos idosos, embora observada uma pequena relação entre o sobrepeso e a depressão esses dados não foram conclusivo, o convívio social refletiu na saúde mental dos indivíduos.
Biotransformations for Fine Chemical Production
Authors: Meyer Hans-Peter , Kiener Andreas , Imwinkelried René , Shaw Nicholas
Published: April 2022

Biotechnology has become an indispensable tool for the production of fine chemicals. The choice of route, chemical or biotechnological, for the manufacture of a given fine chemical is crucial. In general terms, biotechnology is the method of choice for large molecules with a high degree
of functionalisation and multiple stereocentres. Most of LONZA's biotechnological bioprocesses for the production of fine chemicals are whole cell processes using microorganisms which form very specific enzymes. Process improvement at LONZA is discussed in this paper on three
levels: upstream processing, biotransformation/biosynthesis, and downsteam processing.
Application of Enzymes in Industrial Organic Synthesis
Authors: Schoemaker Hans E. , Boesten Wilhelmus H.J. , Broxterman Quirinus B. , Roos Eric C. , Kaptein Bernard , Van den Tweel Will J.J. , Kamphuis Johan , Meijer Emmo M. , Rutjes Floris P.J.T.
Published: April 2022

Aminopeptidase- and amidase-based methods for the production of enantiomerically pure amino acids, intermediates for pharmaceuticals and agrochemicals, are discussed. Furthermore, enzymatic syntheses of the dipeptide sweetener aspartame and semisynthetic antibiotics (such as ampicillin,
amoxicillin, cephalexin, and cefadroxil) are highlighted.
Design and Build Miniature Production System (MPS) on Handling Station and Sort Station Using Cascade Controller
Authors: Yusuf Muhamad , Riyanto Sugeng Dwi , Susanti Hera
Published: April 2022

The sorting process based on color generally still uses human power. This has a weakness, i.e., human judgements that are subjective and inconsistent, and work that is done repeatedly can cause saturation. So, the purpose of this research is to create a sorting system in Miniature Production System (MPS) that can select objects based on color using a TCS3200 color sensor. The novelty of this research is that it can detect primary and secondary colors of an object. The process of moving objects from the storage unit to the sorting section uses a pneumatic cylinder which acts as a handling station. The handling station uses 3 cylinders to move the vertical, horizontal axes and clamp the workpiece. The movement of each cylinder is regulated by a Programmable Logic Controller (PLC) where the ladder diagram is based on the step diagram. Simplification of the step diagram is achieved by using a cascade controller. The testing results shows that this system can sort objects by color with a success rate of 86%. Tests on the handling station show that the average workpiece removal process takes 11.30 seconds with air pressure of 4-5 bar in the cylinder.
The Effect of Capacitors on Frequency Response Amplifier IC TDA2030 as Band-Pass Filter
Authors: Ferdyanto Ferdyanto , Fikri Fauzi Ade , Fadilah Mufti Ahmad , Julian James , Armansyah Armansyah
Published: April 2022

Amplifier is used as an input waveform amplifier by increasing the voltage using an IC power supply. TDA2030 is an amplifier IC with an Output Transformer Less (OTL) type. The amplifier can operate with a voltage of 12 Volt, 1.5 Ampere. The circuit design process uses Proteus software with a universal reference to the TDA2030 datasheet. Proteus experimental results can be seen by simulating the frequency response. Frequency response tests were carried out to obtain filter used for assemble the circuit to produce an ideal Band-pass filter. Then using Digital Oscilloscope, we can observe difference between waves getting emphasis and those they are not. The objective of this study is to determine the value of capacitor C3 with a good  (frequency cut low). Changing value of C3 can produce the desired BPF output. In the experiment, capacitor C3 0.1uf obtained emphasizes low frequencies between 0-250 Hz. Values of C3 with good BPF 47uf and 100uf because the output produced good bass frequency and is suitable for use because the emphasis occurs between 0-5 Hz. On the amplifier IC TDA2030 has made, capacitor C3 with values 47uf and 100uf ideal to be used as BPF because the filter works in a balanced way.
MERETAS KETERASINGAN GURU SEJARAH SMA SUMENEP
Authors: Mawlana Akbar
Published: April 2022

Education has experienced its noble value. Education policy is always intertwined with power. Actualized from government policies that distort PKI material in schools. This makes the teacher experience alienation. The condition of alienation also occurs in the history teacher of SMA Sumenep. However, previous studies have not examined history teachers critically. Therefore, this study examines the isolation of the history teacher at SMA Sumenep from a critical education perspective. This research is qualitative with data collection of observations, interviews, and documentation. The results of the study show that there are differences in interests between history teachers and the government. In addition, education leads to black pedagogy, because the learning process is scary.
ANALISIS KOMPETENSI SOSIAL GURU DALAM PEMBELAJARAN GEOGRAFI PADA MASA PANDEMI COVID-19
Authors: Nurfitka Dini , Asriati Nuraini , Harjanti Diah Trismi
Published: April 2022

This research aims to determine the social competence of teachers in learning geography at SMA Negeri 1 Sungai Raya during the COVID-19 pandemic. The type of research used in this research is descriptive using qualitative methods. The data sources for this study were the geography teachers, the principal, and three students in grades X, XI, XII IPS at SMA Negeri 1 Sungai Raya. This study's data collection techniques were through observation, interviews, and documentation. The data collection tools used were observation guidelines, interview guidelines, and documentation tools. The analysis in this study was presented in a qualitative descriptive manner using two key informants and four supporting informants. The results showed that 1) Teachers in the geography learning process used written communication methods more often during the COVID-19 pandemic. 2) Teachers' communication and information technology were laptops, smartphones, WhatsApp, and google classroom applications in the learning process. There are no obstacles for teachers in using the technology devices, only limited quotas for students and teachers. 3) The way teachers interact and socialize in the learning process is considered suitable for the students.
Profil kemampuan motorik siswa kelas atas Sekolah Dasar Negeri 1 Candi Karanganyar Kebumen
Authors: Widodo Puput
Published: April 2022

Perkembangan zaman dan teknologi menjadikan anak lebih memilih bermain game atau menonton televisi berjam – jam daripada bermain di luar bersama teman - temannya. Hal ini juga di alami oleh siswa SD N 1 Candi, aktivitas siswa pada jam istirahat hanya duduk dan bermain di halaman sekolah dengan alat seadanya. Penelitian ini bertujuan untuk mengetahui seberapa tinggi kemampuan motorik siswa kelas kelas atas. Penelitian ini adalah penelitian deskriptif. Subjek penelitian yang digunakan siswa kelas IV dan V SD Negeri 1 Candi Karanganyar. Pengambilan data menggunakan tes, dengan instrumen dari Nurhasan berupa empat macam tes. Yaitu shuttle run 4 x 10 meter, tes lempar tangkap bola jarak 1 meter dengan tembok selama 30 detik, tes Stork Stand Positional Balance dan tes lari cepat 30 meter. Teknik analis data menggunakan analis deskriptif, yang dituangkan dalam bentuk persentase. Hasil penelitian kemampuan motorik siswa kelas IV dan V di Sekolah Dasar Negeri 1 Candi Kecamatan Karanganyar Kabupaten Kebumen tergolong “Sedang” dengan rincian 3 siswa (9.09%) berkategori baik sekali, 5 siswa (15.15%) berkategori baik, 14 siswa (42.42%) berkategori sedang, 10 siswa (30.30%) berkategori kurang, dan 1 siswa (3.03%) berkategori kurang sekali. Persentase terbanyak pada kategori sedang yaitu sebesar (53% ).
Peningkatan hasil pukulan forhand topsin dengan penggunaan lathan spin whell dan return board
Authors: Safari Indra , Saputra Yuda Munajat , Sudrazat Adang , Susilawati Dewi
Published: April 2022

Teknik pukulan forehand topsin dalam tenis meja merupakan teknik yang dominan dipergunakan. Peningkatan terhadap penguasaan teknik ini sangat perlu diupayakan. Salah satu cara yang dapat dilakukan dengan penggunaan Return board dan Spin whell. Mahasiswa  anggota UKM Tenis Meja yang terdiri dari 30 sampel dengan rentang usia 18-25 tahun menjadi sampel dalam penelitian ini. Pelakukan pada kelompok eksperimen maupun control dilaksanakan, selama dua kali dalam seminggu belangsung selama 16 kali pertemuan. Pengambilan sampel dengan teknik  purposive sampling. Metode penelitian yang digunakan adalah metode penelitian eksperimen dengan desain The Matching-Only Pretest-Posttest Control Group Design. Hasil akhir perlakukan menunjukkan bahwa latihan kedua latihan memberikan pengaruh positif  terhadap peningkatan ketepatan forehand topspin. Kesimpulannya berdasarkan nilai rata-rata kedua kelompok bahwa latihan dengan menggunakan  Return board lebih berpengaruh signifikan dari pada Latihan Spin whell terhadap peningkatan ketepan forhand topspin tenis meja
Pengembangan model permainan dalam pembelajaran pendidikan jasmani untuk peserta didik kelas satu sekolah dasar
Authors: Spyanawati Ni Luh Putu , Sucita Dartini Ni Putu Dwi , Semarayasa I Ketut
Published: April 2022

Tujuan dari penelitian ini adalah untuk mengembangkan model permainan dalam pembelajaran PJOK untuk mendukung pembelajaran tematik untuk kelas 1 Sekolah Dasar pada tema 3 Kegiatanku. Metode penelitian yang digunakan adalah dengan metode R&D yang dikembangkan oleh Borg dan Gall. Sample dalam penelitian ini adalah guru-guru PJOK kelas 1 Sekolah Dasar di Kecamatan Buleleng yang berjumlah 24 orang. Teknik pengumpulan data pada penelitian ini menggunakan instrument penilaian modul“Permainan PJOK Tematik Kelas 1 Tema Kegiatanku” dengan 8 jenis permainan didalamnya yang disesuaikan dengan tema dan subtema.  Berdasarkan hasil analisis data terlihat bahwa rata-rata hasil penilaian uji lapangan permulaan sebesar 83,75% dalam kategori baik. Sedangkan rata-rata hasil penilaian uji lapangan utama sebesar 88,75% dalam kategori baik. Rata-rata hasil penilaian uji operasional sebesar 92% berada dalam kategori sangat baik. Dapat disimpulkan bahwa modul model permainan dalam pembelajaran PJOK untuk mendukung pembelajaran tematik kelas I Sekolah Dasar pada dapat digunakan pada pembelajaran PJOK di kelas 1 tema Kegiatanku.
Evaluasi program latihan psikologi dalam periodesasi latihan di klub Akademi Bola Voli Buleleng (ABVB)
Authors: Danardani Wasti , Hidayat Syarif
Published: April 2022

Tujuan penelitian adalah ingin melihat bentuk program latihan psikologis yang dilakukan di ABVB. Metode penelitian berupa metode survei, untuk mencari informasi langsung kepada pelatih di ABVB yang berjumlah 12 orang. Hasil pati pengumpulan data ini menunjukan bahwa 1) para pelatih telah melakukan pendekatan personal dengan baik, 2) tidak terjemahkannya dengan baik program psikologi dalam periodesai latihan serta 3) pelatih mengerti bentuk latihan dalam program psikologi.
Analisis hubungan status gizi terhadap tingkat kebugaran Jasmani remaja umur 16-17 tahun
Authors: Saparia Andi , Iskar Iskar , Abduh Ikhwan
Published: April 2022

Gizi anak dan remaja menjadi sagat penting dalam menunjang keseluruhan aktifitas yang dilakukan termasuk dalam berolahraga. Penelitian ini dilalukan untuk melihat seberapa besar korelasi antara status gizi anak remaja terhadap kesegaran jasmaninya. Jenis penelitian yang dilakukan termasuk dalam jenis penelitian korelasional. Tempat penelitian di SMA Negeri 1 Lariang. Penentuan sampel yang digunakan adalah menggunakan teknik purposive sampling dengan beberapa kriteria diantaranya anak berumur 16-17 tahun, jumlah sampel yang terlibat sebanyak 20 orang sampel. Body mask indeks (BMI) dan Tes Kesegaran Jasmani Indonesia (TKJI) menjadi instrument pengukuran status gizi dan tingkat kesegaran jasmani siswa. Hasil data penelitian akan di analisis dengan menggunakan teknik analisis regresi. Dari hasil penelitian yang ditemukan menunjukkan rata-rata skor indeks massa tubuh (IMT) sampel sebesar 19.11 dan rata-rata hasil tes kesegaran jasmani siswa sebesar 18.15. Hasil analisis koefisien korelasi juga ditemukan 0,796, hasil tersebut apabila di bandingkan dengan r table 0,444 maka dapat diartikan terdapat hubungan karena nilai r hitung yang ditemukan lebih besar dibandingkan dengan nilai r table (0,796>0,444). Dari data hasil penelitian dan analisis yang dilakukan dapat di simpulkan bahwa tingkat status gizi remaja anak usia 16-17 berkorelasi terhadap tingkat kebugaran jasmaninya sehingga berdasarkan hal tersebut maka di harapkan baik guru dan orang tua agar lebih menekankan makanan dengan prinsip menu seimbang untuk menunjang aktifitas fisik dan belajar siswa
The crux of time: A meta-analysis of ex vivo whole blood degradation
Authors: Elliott Colin , Shafer Aaron , Stotesbury Theresa
Published: April 2022

Estimating the time since deposition (TSD) of a bloodstain can provide important medico-legal information for crime scene investigation. Research in this area primarily investigates the degradation of either hemoglobin or genetic material over time. In this work, we present a comprehensive meta-analysis on bloodstain TSD research. Our results are interpreted from 25 quantitative studies used to probe the effect of biomolecule studied, analytical technique used, substrate porosity, environmental conditions, and blood source on TSD estimates. There was an overall strong effect of time across studies (Fisher’s Zr = 1.66, r = 0.93), and generally, we found that the type of biomolecule studied (e.g., hemoglobin, DNA) had equal effect sizes for TSD estimation. Differences in the mean TSD effect size were also observed between substrate porosity. Interestingly, the blood source does not significantly influence the magnitude of the effect sizes in TSD estimation. Despite the clear effect of time, forensically relevant prediction of bloodstain TSD remains complicated by inter-donor variability, type of substrate and environmental conditions. We recommend that future bloodstain TSD research increase sample size, include summary statistics and standardize experimental methodologies so that we can develop a quantitative understanding of the physicochemical processes involved in whole blood degradation in ex vivo conditions.
Impact of applicability domains to generative artificial intelligence
Authors: Langevin Maxime , Grebner Christoph , Guessregen Stefan , Sauer Susanne , Li Yi , Matter Hans , Bianciotto Marc
Published: April 2022

Molecular generative artificial intelligence is drawing significant attention in the drug design community, with several experimentally validated proofs of concepts already published. Nevertheless, generative models are known for sometimes generating unrealistic, unsynthesizable or unstable structures. This calls for methods to constrain those algorithms to generate structures in reasonable portions of the chemical space. While the concept of applicability domains (AD) for predictive models is well studied, its counterpart for generative models is not yet defined. In this work, we examine empirically various possibilities and propose applicability domains suited for generative models. Using both public and internal datasets, we use state-of-the-art generative methods to generate novel structures that are predicted actives by a corresponding QSAR model, while constraining the generative model to stay within a given applicability domain. Our work looks at several applicability domain definitions, combining various criteria, such as structural similarity to the training set, similarity of physico-chemical properties, unwanted substructures, and Quantitative Estimate of Drug- Likeness (QED). We assess both from a qualitative and quantitative point of view the structures generated, and find that the applicability domain definitions have a strong influence on the chemical beauty of generated molecules. An extensive analysis of our results allows us to identify applicability domain definitions that are best suited for generating drug-like molecules with generative models. We anticipate that this work will help foster the adoption of generative models in an industrial context.
Floristic Indices and ion content of Some Medicinal Plants along Sand Dunes Altitude in Cholistan Desert of Pakistan
Authors: Yasin Ghulam , Anwer Iqra , Ahmad Aqsa , Altaf Adeela , Saima Shahzadi , Kanwal Asma
Published: April 2022

The present study was conducted to explore the nutrient ions status, their uptake ratio and floristic indices of some medicinal plants of Cholistan desert of Pakistan from Drawar fort area. Vegetations on sand dunes of approximately equal size were evaluated with three replications. In soil of zone 1 (top of dune), maximum frequency (100) of Caligonum polygonoides and minimum (33.34) of Salsola imbricata and Capparis decidua were recorded. In soil of zone 2, maximum frequency (100) of Caligonum polygonoides while minimum (33.33) of Calotropis procera while in zone 3, 100% frequency of lonely species Symbopogon jawarancusa was observed. In soil of zone 1, maximum concentrations were of sodium (Na), bicarbonate (HCO3), nitrogen ((N) and organic matter (OM) while in soil of zone 2, EC, pH, phosphorus (P) and potassium (K) were maximum. Leaf K and Na were the highest (27.10mg/g) and (118.36mg/g) respectively in Prosopis cineraria. Leaf P was the highest (0.42mg/g) in Prosopis cineraria also. Maximum stem Na (333.00mg/g) was in Salsola imbricata. In flowers, highest P (0.42mg/g) was found in flower of Salsola imbricata.
Design, Characterization, Analytical HPLC Method Validation, and Stability Studies of Racecadotril Capsules
Authors: Ishtiyaq Wajeeha , Tariq Arslan , Abbas Nasir , Ashiq Kanwal , Asif Bajwa Mayyda , Aslam Aysha , Fatima Azka , Ashiq Sana
Published: April 2022

This study aims to develop, characterize and validate analytical method and perform stability studies of Racecadotril capsules to treat acute diarrhea. Six formulations of Racecadotril 100mg Capsules were prepared with different excipients by varying their concentrations. The HPLC method was validated on analytical parameters recommended by ICH Q2R guidelines, including specificity, accuracy and recovery, precision, quantitation limit, detection limit, range, linearity, and robustness. Forced degradation studies were performed as per the Stability Indicating Method under various stress conditions. Accelerated stability studies were performed on three stability batches of best fit formulation of Racecadotril 100mg Capsules as per ICH guidelines. Among the six formulations of Racecadotril 100mg Capsule, F6 was the best fit with a comparatively good dissolution profile with 76.9% release in 60 minutes. The HPLC system was suitable as % R.S.D. was 0.619147%, within the acceptance criteria. Furthermore, parameters including specificity, accuracy and recovery, precision, quantitation limit, detection limit, range, linearity, and robustness lie within the acceptance criteria. The percent degradation of Racecadotril after photolytic (sunlight for 6 hr.), oxidative (3% H2O2), acidic (0.1N HCl) and necessary (0.1N NaOH) stress was found to be 6.5%, 5.8%, 11.4%, and 28.4%, respectively. The product remains unchanged after thermal stress. HPLC method was successfully validated for Racecadotril 100mg Capsule as per ICH Q2R guidelines.
Analysis and Exploitation of the Condensed Water of Chillers
Authors: Hassan Ather , Ilyas Syed Zafar , Jamro Deedar Ali , Bhatti Zubeda , Mufti Hareem , Niazi Nasrullah Khan
Published: April 2022

Energy resources are going to be exhausted in the near future. It is essentially required to use the energy in an organized manner. Therefore, the chiller’s condenser water has been focused to utilize the maximum of the input energy of the machine. This water can be categorized as distilled water if the contamination level is zero. The low-graded distilled water can be used in steam generators; acid-based Batteries, chemical dilution and even can be used in vehicle radiators to avoid blockades of pipes. Generally, the production of distilled water requires a lot of energy. In the present work condensed water of domestic chillers has been analyzed for contaminants to decide its future use. Five samples were collected from chillers installed in the city of Gurrah Mohallah Mandi Bahauddin, in the Punjab province of Pakistan. Using the ethylene diamine tetra acetic acid (EDTA) titrimetric method,a small amount of Ca, Mg, Pb, and SO4 were detected that confirmed the conductivity of water around 81μS/cm. The magnitude of Total Dissolved Solids (TDS) was 54 mg/L, pH was 6.2 and total hardness was recorded about 0.576 mg/L.
TELOMERE LENGTH AS A BIOLOGICAL MARKER FOR ASSESSING THE SERIOUSNESS OF PNEUMONIA OF VARIOUS ETIOLOGIES
Authors: I.V. Mironov , A.V. Gordienko , B.A. Chumak , N.I. L'vov
Published: April 2022

Abstract. The results of the features of the clinical course of pneumonia of various etiologies are presented, taking into account the epigenetic indicator of the human body, such as telomere length. We examined 102 male military personnel who were treated at the hospital therapy clinic of the Military Medical Academy named after S. M. Kirov. The patients were divided into two groups: group I of 63 people aged 37,3±6,7 years with pneumonia caused by a new coronavirus infection; Group II - 39 men aged 41.4±5.3 years with bacterial pneumonia of various etiologies. Patients were examined and treated according to the standard scheme. In the group of severe viral pneumonia, a significantly larger volume of lung parenchymal damage was determined, a decrease in saturation to 91,3±1,6% (p=0,003); myocardial damage: an increase in troponin T up to 15,6±5,3 ng/l (p=0.001), an increase in total CPK, AST and ALT compared with patients of group II. In group I, evaluating the results of hemogram parameters, attention is drawn to the tendency to thrombocytopenia (172±29x109/l, p=0,03), the tendency to leukopenia (4.1±1,2x109/l) in severe disease. There was a significant increase in CRP, D-dimer and ferritin in severe viral pneumonia in men of group I, which can be characterized as coagulopathy associated with the risk of developing arterial and venous thrombosis because of microthrombovasculitis. Telomeres are specialized functional complexes that are located at the ends of chromosomes and protect them from fusion with each other, which preserves the integrity of the eukaryotic cell genome. Telomere length is an important characteristic of a person’s overall health. It is associated with such characteristics as longevity or the affinity of the human body to various diseases, such as type 2 diabetes mellitus, hypertension, coronary heart disease, and others. In this scientific study, change in length lomer in patients with pneumonia of various etiologies. The most pronounced shortening of telomere length was found in patients with severe viral pneumonia (significant shortening of telomere length by more than 2000 base pairs), compared with bacterial pneumonia. The identified changes can be used to predict an unfavorable outcome of pneumonia caused by a new coronavirus infection, for example, the development of such a formidable complication as a “cytokine storm”. The obtained preliminary results make it possible to consider telomere length as a specific biological marker for assessing the severity of pneumonia caused by the SARS-CoV-2 virus.
MANAGEMENT TACTICS OF PATIENTS WITH HYPERPLASTIC SYNDROME AND ANEMIA
Authors: O.B. Kalinkina , Yu.V. Tezikov , I.S. Lipatov
Published: April 2022

Abstract. The study of this clinical case made it possible to demonstrate the effectiveness of the management tactics of a patient with hyperplastic syndrome and anemia using hormone therapy with Buserelin- Long (an agonist of Hh-RG) for six months, followed by an operative stage (uterine artery embolization). The patient had relief of chronic pelvic pain by the third month of treatment with Buserelin -Long. In the future, the patient did not have a resumption of pain syndrome. During the control examination of the patient six months after the start of treatment, positive dynamics in the treatment of the hyperplastic process was revealed, expressed in a decrease in the size of intramural myomatous nodes, the absence of recurrence of the endometrial hyperplastic process, relief of pain and abnormal uterine bleeding. At the initial treatment of the patient, clinical and laboratory data were revealed confirming her chronic posthemorrhagic iron deficiency anemia. The indicators of clinical and biochemical blood tests reached the limits of reference values during the control examination after 6 months of Buserelin –Long therapy, which indicates the effectiveness of this management tactic in patients with hyperplastic syndrome and anemia. No adverse reactions were detected during treatment. The patient noted the good tolerability of the drug as well as the rapid and effective relief of the manifestations of the disease. Thus, based on the study of this clinical case, we can conclude about the effectiveness of the proposed management tactics for a patient with hyperplastic syndrome and anemia and recommend the use of this type of therapy in patients with similar pathology.
THE STUDY OF THE CHEMICAL COMPOSITION OF THE ESSENTIAL OIL OF THE RAW MATERIAL OF THE HERB TANACETUM VULGARE, OBTAINED BY DIFFERENT METHODS OF HYDRODISTILLATION
Authors: Ya.V. Stoyanova , A.V. Strelyaeva , R.M. Kuznecov , N.D. Strelyaev
Published: April 2022

Abstract. The study of medicinal plant materials has always been relevant and necessary, since herbal preparations take care of the human body, have a complex effect and, if it used correctly, do not have side effects. The study of medicinal plant raw materials of Tanacetum vulgare herb is relevant, because. this is a fairly common plant in Russia, but there is insufficient research. The aim of this research was to study the chemical composition of the essential oil obtained by two different methods of hydrodistillation, as well as to conduct a comparative analysis of the chemical composition of these samples, to determine marker compounds and carry out standardisation. The essential oil was obtained from the dried herb of Tanacetum vulgare. The first and second methods of the hydrodistillation were used – the Ginsberg method and the Clevenger method. The method of chromato-mass spectrometry, as well as the method of thin layer chromatography was used to identify the component composition of the essential oil. It was found that in the essential oil, which was subjected to prolonged exposure to temperature (Ginsberg's method), there were mainly oxidised, acetylated forms, as well as aromatic structures. In the essential oil, where the effect of temperature was minimised (the Clevenger method), there were more reduced forms, OH-groups and unsaturated compounds. It was concluded that the Clevenger method is more advantageous for obtaining essential oil of Tanacetum vulgare, since the essential oil in this case was subjected to minimal heating, and hence oxidation. Marker substances of the essential oil of herb of Tanacetum vulgare were isolated, such as camphor (15,8%), 2-pinene-10-ol (7,4%), limonene (1,5%), borneol (6,6%), 4-terpineol (3,14%), thujone (0,02%), etc. The absolute content of camphor in essential oil is 1.19±0.05.
PERSONALIZED RISK ASSESSMENT OF RAPIDLY PROGRESSIVE ATHEROSCLEROSIS
Authors: O.M. Parkhomenko , N.G. Lozhkina , Yu.E. Voskoboinikov
Published: April 2022

Abstract. Вackground. Progressive atherosclerosis is accompanied by unfavorable clinical outcomes, study and understanding of this process, creation of risk assessment method is necessary for individualization of approaches to treatment and prevention of this condition.
Purpose of the study. Creation of risk assessment method of atherosclerosis progression for personalized approach to treatment, rehabilitation and secondary prevention.
Patient Characteristics and Study Methods. A retrospective cohort study included 202 patients with coronary heart disease: 147 men and 55 women. The mean age of the patients was 53.3±7.16 years. Group 1 included patients who had had myocardial infarction or unstable angina, emergency arterial stenting, stroke, peripheral artery thrombosis, critical ischemia, and lower extremity amputation within 2 years before study inclusion. Patients in the comparison group did not have these events. The influence of each of the studied parameters on the probability of fast progressing atherosclerosis was determined by factor and correlation analysis.
Results. As a result of the study, an innovative method for predicting the risk of developing rapidly progressing atherosclerosis in a patient was developed, including determining the patient's age, the presence or absence of carotid stenosis by 50% or more of the vessel lumen on at least one side, body mass index obesity, history of stable angina pectoris, high-sensitivity C-reactive protein (hsSRP) and high-density lipoprotein cholesterol (HDL-cholesterol) serum concentrations. The sensitivity, specificity and accuracy of the proposed method are above 80%. An application for the registration of the invention was filed to the Russian Federal Service for Intellectual Property, Patents and Trademarks (Rospatent).
Conclusion. The proposed model was developed on the basis of studying the indexes in Russian patients. It shows the weight of one or another factor that influences the probability of rapidly progressing atherosclerosis. The model is easy to use and allows to individualize prophylaxis in this category of patients.
CLINICAL AND STATISTICAL ANALYSIS OF FRACTURES OF THE CONDYLAR PROCESS OF THE MANDIBLE IN THE CHUVASH REPUBLIC
Authors: A.V. Osipova , V.V. Trubin , R.S. Matveev
Published: April 2022

Abstract. The actual problem of maxillofacial traumatology is the treatment and rehabilitation of patients with fractures of the condylar process of the lower jaw, since they are the most difficult for both diagnosis and treatment. The aim of this study was to study the regional features of the diagnosis and treatment of fractures of the condylar process of the mandible at the outpatient and inpatient stages of specialized medical care on the example of the Chuvash Republic. To analyze the current situation regarding the diagnosis and treatment of fractures of the condylar process of the lower jaw in the Chuvash Republic, we conducted a retrospective analysis of the case histories of the department of maxillofacial surgery of the budgetary institution of the Chuvash Republic "Emergency Hospital" of the Ministry of Health of the Chuvash Republic and outpatient cards of the Department of Emergency Dentistry of the Chuvash Republic "City Dental Clinic" of the Ministry of Health of the Chuvash Republic for the period from 2015 to 2019. The frequency of fractures of the condylar process of the lower jaw is in the range of statistical data given in the literature, and is 28,0±4,42% of all fractures of the lower jaw. It was found that patients with multiple fractures of the mandible involving the condylar process (84,33 ± 4,6%) are more often treated in the hospital, and patients with isolated unilateral fractures of the condylar process of the mandible (63,16 ± 8,24%) are treated on an outpatient basis. %). The main method of treatment of fractures of the condylar process of the lower jaw in outpatient and inpatient conditions remains the method of splinting: 100% and 91,79±3,98%, respectively. In all cases, without the recommended interdental occlusal pad. Analysis of medical documentation revealed the absence of control radiography in the hospital in the treatment of fractures of the condylar process of the lower jaw in 61,94±2,32% of cases. The analysis of the conducted control studies showed that after splinting without the recommended interdental occlusal lining, the displacement of fragments remained in 40,52±4,88% of patients in the Department of Maxillofacial Surgery and in 19,74±9,86% of patients in the Department of Emergency Dentistry.