bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative study of caries removal using BRIX 3000 and classic mechanical method
Authors: Eftimoska Marina , Petroska Ana , Terzievski Boban , Rendzova Vasilka , Apostolska Sonja
Published: July 2022

Introduction. In dental practice, despite the constant improvement of dental
equipment and materials, caries removal using rotational instruments is
still not a satisfactory way. The caries removal treatment constantly offers
numerous alternatives in order to replace machine tools, and one of them is
the chemo-mechanical method. The aim of this paper is to examine the
effectiveness of the chemo-mechanical method of caries removal using BRIX
3000 and classic method. Material and Method. We used BRIX 3000; a material
intended for atraumatic caries removal. Both caries elimination methods were
performed in 40 patients with evident carious lesions. Twenty patients
underwent atraumatic caries removal while in the other twenty carious tissue
was removed using rotating instruments. Results. BRIX 3000 was effective in
caries removal. A significant reduction in the use of local anesthetics was
noticed. Patients did not experience discomfort or pain during treatment
with BRIX 3000, but the duration of caries removal using this atraumatic
method was significantly longer than with the classic method. Conclusion.
Atraumatic method of caries removal is an adequate alternative to
conventional therapeutic procedures for caries removal, which finds a place
in the domain of modern minimally invasive dentistry.
Mg and Si substituted hydroxyapatite: Behaviour in simulated body fluid
Authors: Petrovic Bozana , Krstic Maja , Mudrinic Tihana , Cebela Maria , Dutour-Sikiric Maja
Published: July 2022

Due to its similarity with biological apatite found in vertebrate hard
tissues, calcium hydroxyapatite is one of the most investigated materials in
bone tissue engineering. As the biological apatite is not stoichiometric,
ion substituted hydroxyapatites attract much atention since they more
closely mimic the composition of natural bone. Although there are many
investigations of the influence of foreign ions on the structure and
physico-chemical properties of ion-substituted hydroxyapatites, there is
scarse information on their behaviour in different media. In the present
study, magnesium (Mg), that plays a key role in bone metabolism and silicon
(Si), that is necessary for normal skeletal development, were used as ion
substitutes. The behaviour of Mg and Si substituted hydroxyapatite in
simulated body fluid was investigated by XRD, FTIR and SEM. Obtained results
confirmed great potential of these substituted hydroxyapatites for
biomedical applications.
Preparation and characterization of novel glycidyl methacrylate/clay nanocomposites
Authors: Stefanovic Ivan , Markovic Bojana , Nastasovic Aleksandra , Vukovic Zorica , Dapcevic Aleksandra , Pavlovic Vladimir
Published: July 2022

The impact of the type and amounts of nanofiller on the features of the
glycidyl methacrylate-co-ethylene glycol dimethacrylate
(GMA-co-EGDMA)/organomodified montmorillonite (OMt) nanocomposites that were
prepared by in situ radical suspension polymerization, was examined.
Cloisite 30B and Cloisite 25A were used in this study as nanofillers, in
amounts of 2 and 10 wt.%. The structure, morphology, thermal stability and
porosity of the initial GMA-co-EGDMA copolymer and their nanocomposites were
examined by ATR-FTIR analysis, wide angle X-ray diffraction (XRD), scanning
electron microscopy with energy-dispersive X-ray spectroscopy (SEM-EDS),
transmission electron microscopy (TEM), thermogravimetric analysis (TG) and
mercury porosimetry. It has been established that both clay nanofillers were
successfully incorporated into the structure of the initial copolymer,
simultaneously on their surface and also on cross-sectional area. Prepared
samples with 2 wt.% have predominantly exfoliated, while samples with 10
wt.% have some tactoids-aggregates structure of the OMt layers.
Thermogravimetric analysis revealed that after ~ 30 % of degradation, all
nanocomposites become more thermal stable than the initial copolymer. The
obtained results indicate that porosity parameters can be easily modified
with the addition of clay nanofillers and thus prepared nanocomposites
adjusted to specific purposes.
Anesthetic Management of a Patient With Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Shionoya Yoshiki , Hirayama Kaoru , Saito Kaho , Kawasaki Eriko , Kantake Yoko , Okamoto Hazuki , Goi Takahiro , Sunada Katsuhisa , Nakamura Kiminari
Published: July 2022

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmogenic disorder induced by adrenergic stress. Electrophysiologically, it is characterized by emotional stress- or exercise-induced bidirectional ventricular tachycardia that may result in cardiac arrest. Minimizing perioperative stress is critical as it can reduce fatal arrhythmias in patients with CPVT. Dexmedetomidine (DEX), a centrally acting sympatholytic anesthetic agent, was used in the successful intravenous (IV) moderate sedation of a 27-year-old female patient with CPVT, a history of cardiac events, and significant dental fear and anxiety scheduled to undergo mandibular left third molar extraction. Oral surgery was successfully performed under DEX-based IV sedation to reduce stress, and no arrhythmias were observed. IV sedation with DEX provided a sympatholytic effect with respiratory and cardiovascular stability in this patient with CPVT who underwent oral surgery.
A Survey of Dentist Anesthesiologists on Preoperative Intramuscular Sedation
Authors: Guthrie David B. , Epstein Ralph H. , Boorin Martin R. , Sisti Andrew R. , Romeiser Jamie L. , Bennett-Guerrero Elliott
Published: July 2022

Objective:

The induction of general anesthesia for children and patients with special needs frequently requires preinduction sedation, especially when anxiety and agitation lead to violent or combative behavior. In these situations, preoperative intramuscular (IM) sedation may facilitate patient transfer, intravenous cannulation, and/or mask induction. This survey aimed to capture data regarding the current preoperative IM sedation practices of dentist anesthesiologists.

Methods:

An electronic survey was distributed in 2020 to all members of the American Society of Dentist Anesthesiologists regarding the administration of preoperative IM sedation. It included questions about the demographics of respondents and their patients who require IM sedation, the most common drug regimens used, decision-making criteria regarding ketamine dosing, the intended level of sedation, sequence of anesthetic management following IM sedation, and observed outcomes.

Results:

A total of 193 responses (43%) were received; of those, 162 reported using preoperative IM sedation. Ketamine was included in 98.7% of reported IM drug regimens. The most common IM sedation regimen was combined ketamine and midazolam (median 2.5 mg/kg and 0.1 mg/kg, respectively). Of the respondents who use preoperative IM sedation, 87% reported using the same drug regimen in at least 80% of cases.

Conclusion:

The most frequently reported drug regimen used by dentist anesthesiologists in North America for preoperative IM sedation was a combination of ketamine and midazolam.
Ergonomic Risk Evaluation of Manual Material Handling in Brick Production
Authors: Pratiwi Indah , Kalyana Valeska Salsabil
Published: July 2022

The manual material handling (MMH) activity of making bricks causes workers to use energy throughout their body to do work so that it can pose a potential ergonomic hazard. Ergonomics hazards caused are fatigue in the muscles due to repetitive movements, poor work posture, too heavy load, inadequate tools, unsupportive environmental conditions. Complaints of Musculoskeletal disorders (MSDs) that accumulate will have a major impact on bone structure disorders and muscle disorders.The purpose of this study was to evaluate the ergonomic risks and complaints of MSDs in MMH activities using a trolley. The research method used is the risk assessment of pushing and pulling (RAPP) tool and Nordic body map (NBM). The RAPP Tool consists of 9 assessments with a rating scale of good, reasonable, poor and unacceptable. Furthermore, using the NBM which mapped 28 body parts with a rating scale of no pain, moderately ill, sick and very sick.The results of the study contained 3 assessments of the RAPP Tool with the highest score, including floor surface, posture, and condition of the tool. The results of the NBM found that the body parts that often felt complaints were the back, waist, buttocks, left knee, right knee, left leg and right leg. The conclusion is that workers with high RAPP scores have an impact on high levels of muscle complaints so that improvements need to be made immediately to reduce ergonomic risks to workers.
Ekranisasi Sastra terhadap Alih Wahana Novel Soe Hok Gie: Catatan Seorang Demonstran ke dalam Film “Gie”
Authors: Anggraini Dwi , Dewi Trie Utari
Published: July 2022

The emergence of Ecranization in the development of Indonesian literature is increasingly rapid with the help of technological advances. Therefore, the phenomenon that occurs in the transfer of the novel medium into the film can indirectly be studied because it is part of the various changes that occur in the world of literature. This study discusses the literary ecranization of the novel Soe Hok Gie: Notes of a Demonstrator into the film Gie by finding various changes from the novel into the form of a film, such as reductions, additions, and changes in variations. The method used in this research is descriptive qualitative method. The theory used in this study refers to the views of Damono (2012) and Eneste (1991). Data collection techniques used observational techniques and note-taking techniques. The results of this study indicate that there are reductions (2 data), additions (2 data), and changes in variation (6 data) in the ecranization of Soe Hok Gie's novel: Notes of a Demonstrator. Overall, the literary ecranization from the novel to the film greatly influences the storyline about the character of a Gie depicted through the film Gie.
Nilai-Nilai Moral dalam Kumpulan Puisi “Senja Di Batas Kata” Karya Dimas Arika Miharja
Authors: Maiza Suci , Rifki Ansanul
Published: July 2022

This study aimed to describe the moral values of  poetry ”Senja di Batas Kata “by Dimas Arika Miharja. The Theory supporting use Nurgiantoro (2019) Pradopo (2005). The study used the qualitative approach with a descriptive method with content analysis. The data of this reseach are in the form of words, phrases, or sentence which are physcal and mental elements of poetry. These elements are used to find moral values in poetry.  The research data was in the form of text which contained the moral values of the poetry ”Senja di Batas Kata” by Dimas Arika Miharja. The results showed that the supporting structures of the ”Senja di Batas Kata” poetry were existed, namely  thephysical and mental structures. Based on the analysis of the physical and mental elements, it found that the moral values of poetry “Senja Di Batas Kata”by Dimas Arika were related to the personal character building, such as (1) dare to defend the truth, (2) be aware and careful to all events, (3) virtuous, Moral values related to social character building were (1) love each other, (2)advice each other and cooperate. There are three moral values of human relations with God, (1) faith, (2)worship and seeking God and (3)remembering death.
Tahapan Pemerolehan Bahasa Anak Melalui Video Youtube Mitigasi Bencana: Studi Kasus pada Nick
Authors: Bhaga Bertholomeus Jawa , Lautama Muhammad , Suci Maria Theresia Cita
Published: July 2022

At the beginning of a child's life, of course, always goes through a stage called language acquisition. With language skills, you can interact with other people. The purpose of this study was to identify the stages of language acquisition in children, a case study on Nick. This research is a qualitative research with a descriptive method that seeks to describe the stages of language acquisition in Nick. The procedure is that data is collected, reduced and analyzed about the stages of language acquisition for Nick. This can be found when Nick invites his parents to avoid disaster hazards with various invitations such as in the disaster mitigation video that he has watched before.
Female Swearing on WhatsApp Communications: A Sociolinguistics Perspective
Authors: Kurniawanti Fahrisal , Damanhuri Adam
Published: July 2022

Traditionally, swearing was considered a taboo subject. However, in today’s era swearing has become a common thing.  It is practiced not only by men but women also practice it. To avoid social impoliteness, it is practiced in various ways, purposes, and languages based on the context. This research analyzed the types and functions of English swearing used by females on WhatsApp seen from a sociolinguistics perspective. Ljung (2011) and Vingerhoets & Bylsma (2013)’s theories were applied in this research. Observations were conducted through WhatsApp stories in gaining eight written utterances data and virtual interviews were conducted by eight participants in gaining the functions of swearing data. The results show four types of swear words covered the use of swearing, namely: religious theme, scatological theme, sexual activities theme, and mother/family theme. Each of these themes has different functions depending on the context of utterances. Other results indicate that females function English swearing in intra-individual and inter-individual. Intra-individual functions lead to show anger, frustration, and annoyance. Inter-individual functions lead to insulting others and showing solidarity. These functions were triggered by positive emotions (excitement and chill out with friends) and negative emotions (anger, frustration, and annoyance). Mostly Females swear triggered by negative emotions.
Surgical Specifics of Lower Limb Superficial Thrombophlebitis Combined with Undifferentiated Connective Tissue Disease
Authors: Timerbulatov M. V. , Murasov T. M. , Murasov A. M.
Published: July 2022

Background. Superficial thrombophlebitis of lower extremities is among the most frequent acute vascular pathologies. Concomitant undifferentiated connective tissue dysplasia exerts specific changes in its clinical course.

Aim: A study of the specific dynamics of acute lower limb superficial thrombophlebitis (ST) and its surgical treatment in patients with undifferentiated connective tissue dysplasia (UCTD).

Materials and methods. The case histories, surgery reports and follow-up examinations of patients treated at the Vascular Surgery Unit during 2012–2020 were analysed. A total of 86 patients had signs of UCTD and underwent classical crossectomy of the great saphenous vein (Troyanov operation).

Results and discussion. Duplex ultrasound of lower limb veins in 34 (39.53 %) patients revealed a discrepancy between the upper localisation of thrombotic masses in the great saphenous lumen and the external boundary registered for clinical manifestations, hyperaemia and tissue thickening. In 69 (80.23 %) patients, four or more phenotypic UCTD markers were exposed. In 74 (86.05 %) cases, a classical Babcock phlebectomy was performed as a next stage within one year after an acute thrombophlebitis attack had subsided. Of 12 (13.95 %) patients not having had a second-stage phlebectomy within one year: 4 people had UCTD signs — they refused surgery due to absent significant complaints or marked saphenous reflux; 3 had a deep vein thrombosis episode; 5 had no saphenous reflux of lower extremities in ultrasound examination.

Conclusion. The registration of phenotypic signs of undifferentiated connective tissue dysplasia is recommended in choosing a surgical tactic to treat acute ascending thrombophlebitis of lower limb saphenous veins.
Prevention Of Drug-Induced Osteonecrosis Of The Jaw In Cancer Patients
Authors: Spevak E. M. , Christophorando D. Yu. , Shutov V. A. , Ermakova A. V.
Published: July 2022

The occurrence of drug-induced osteonecrosis of the jaw in cancer patients treated using bone-modifying medications (bisphosphonates and denosumab) is a highly relevant research problem studied by dentists, maxillofacial surgeons, and oncologists. Despite the large number of publications, practical approaches to preventing drug-induced osteonecrosis of the jaw remain to be developed, which is confirmed by the increasing prevalence and severity of the clinical course of the disease. In this article, we review the most significant works and position papers published in Russia and abroad over the past 10 years, as well as the authors’ scientific and clinical experience, in order to identify key reasons behind the ineffective prevention of drug-induced osteonecrosis of the jaw in cancer patients and to suggests possible solutions. Questions concerning the legal protection of patients and clinicians in relation to this complication are discussed. Most recent achievements in the field of laboratory diagnostics and risk assessment of drug-induced osteonecrosis of the jaw in cancer patients, including the determination of bone metabolism markers, are presented. The following criteria for the safe use of bisphosphonates and denosumab in cancer patients were identified: dental screening; clinical and laboratory monitoring; individualizing drug dosage, duration and withdrawal regimens; application of an interdisciplinary approach.
Pengaruh jumlah sudu terhadap unjuk kerja 3D print turbin air tipe vortex
Authors: Nugroho Alvin Dio , Suwandono Purbo , Hermawan Dadang , Fadhillah Arief Rizki
Published: July 2022

The potential of natural resources in the form of water energy is a renewable natural resource that is often used because it does not damage the environment and can be used continuously. This water flow has two types, namely laminar flow and turbulent flow, the forces generated from these two flows are also different. Turbulent flow tends to produce a greater force and can lift object masses better than laminar flow. Therefore, a vortex turbine has emerged which utilizes turbulent flow as a waterwheel drive, by directing laminar flow towards the cross section and converting it into turbulent flow by utilizing the force of gravity and The cross-sectional shape forms a whirlpool that can move a waterwheel and turn a turbine. The number of blades is very influential on the performance generated from the vortex turbine and affects the resulting output, be it voltage, current, rotational speed, torque and efficiency. In this study, the best results were shown on blades with a total of 6, at a rotational speed of 141.3 rpm; at the voltage shows the result of 0.28 volts; at current it produces 44 mA; at Torque (Nm) 0.22 Nm; and the efficiency is 76.5%.
Analisis kekerasan dan keausan bearing pada pesawat Cessna Grand Carravan 208B
Authors: Septiyanto Muhammad Abdul Rafiq , Suroso Indreswari , Utami Noviana
Published: July 2022

Bearing is a surface component that protects two parts that rub against each other. Bearings have several components including inner rings, roll bearings and supports. Bearings will experience weariness when used continuously, so the purpose of this study is to determine the level of hardness and wear of each bearing component of the Cessna Grand Caravan 208B aircraft. Hardness testing is carried out by vickers method and test sampling is carried out at three different points in each specimen. Wear testing uses the Ogoshimethod and test sampling is performed at three different points in each specimen. The results of this study concluded that vickers hardness testing received the highest hardness score on the roll with an average value of 739.7 VHN, the second highest hardness in the inner ring had an average hardness value of 695.1 VHN, and the lowest hardness in the buffer section had an average hardness value of 110.2 VHN. The wear test results get the highest value on the support section which is 0.00273 mm³ / kg.m, the second highest wear on the inner ring is 0.00133 mm³ / kg.m, and the lowest wear value on the roll is 0.00056 mm³ / kg.m.
Encouraging Guidelines in Neuromusicological Research Regarding Classical Music’s Usage in Sonic Therapy - When Science Becomes Magic
Authors:   Senior lecturer PhD, Faculty of Letters and Arts, Partium Christian University, Oradea, Romania. Email: csakany.csilla@partium.ro., Csákány Csilla
Published: July 2022

"In systematic musicology as a branch of music psychology we found an intriguing orientation called cognitive neuroscience of music, or neuromusicology. It studies the function of the brain in music processing, the way music perception and production manifests in brain. Compared to other analytical models of music cognition, the mapping of the brain’s functioning serves to examine the outcome of music rather than its process, and as the music therapy methods discussed reflect, most approaches follow this ontological direction. As recent scientific researches shows, the brain mapping technique differentiates moment of listening, playing classical music or improvising. In the light of the research findings, our main focus was to get to know and understand how our musical brains functions during classical music audition so we could argue from a scientific approach not only the existing therapeutic methods used in music therapy, but the perception of classical music in the present. In the master class “Dialogue of the Arts”, we explore with our students in all grades the possible links between music and other artistic and scientific disciplines. One of the most exciting aspects of this is music and brain research, an incredibly fast-developing field whose results could reinforce the place and role of classical music in contemporary society, reinforcing existing broad-based promotion of classical music education (Kodály, El sistema etc.) Keywords: music cognition, neuromusicology, sonic therapy, classical music, models of therapy. "
A Perspective on the Opera Audience of the 21st Century
Authors:   Lecturer PhD, Opera Singer, Faculty of Music, Transilvania University, Brașov, Romania. Email: cristina.radu@unitbv.ro., Radu-Giurgiu Cristina
Published: July 2022

"When it comes to contemporary audience of the opera, we have in mind a multitude of individuals with extremely diverse and heterogeneous cultural backgrounds, very different tastes and expectations related to the show and to the artists who perform on stage. Perhaps the famous Italian loggionisti who once made up the dreaded galleries, although still present, are no longer as influential as in the past centuries; and the splendid euphoria of the opera lovers from the 1950s and 1960s has faded. The extremely refined and knowledgeable elite is also becoming less numerous. But Opera still incites the interest of the public and arouses passions at the same time. Who is today's audience and what makes them attend and influence the Opera show? What are the managerial strategies for attracting new audience to the auditorium? The social distancing and the restricted access of the public in the performance halls during the recent coronavirus pandemic is also highlighted in the article. Keywords: Opera Audience, 21st Century, communication, audience reception "
Das Gebet „Vaterunser” in der komponistischen Sicht von Ciprian Porumbescu – theologische und musikologische Aspekte
Authors:   Pfr. Doz. Dr. Habil., ‟Episcop Dr. Vasile Coman” Ortodoxe Theologische Facultät, Oradea Universität, Rumänien. Email: mihaibrie@yahoo.com., Brie Mihai
Published: July 2022

"The Messianic model of prayer uttered on the Mount of Olives, which has become a standard for the entire treasury of the later church, is our interdisciplinary research today. Given that it was uttered by Jesus Christ himself, it becomes relevant to any believer who wants his daily life to be in continual communion with God. In the liturgical richness of the Christian church of all times, the Lord’s Prayer (Our Father) is an integral part of any time of the day, morning, noon, or evening, because it represents the quintessence of the key words that every Christian visionary must have in his vocabulary. daily. In the following I have prepared research meant to attract the musician or theologian, or the contemporary scientist in the pragmatization of the manipulative requests contained in this grandiose prayer. Thus, we combined theological research with musicological research in an exceptional composition from the old Romanian space. In the history of the local culture and civilization, famous names have remained that have shaped the Romanian academic space from all times. One of these names of scientific relevance was Ciprian Porumbescu. Endowed natively with hard work, he succeeds and confirms over time his passage through time. A plurivalent musician, but also a poet and essayist, he manages to imprint in the history of the second half of the 19th century a unique perspective on the religious and folkloric and patriotic treasure of Bucovina. All this treasure is haloed by its vast improvement in Chernivtsi and Vienna, inscribing itself in the memory of the musical times of the end of the 19th century both far from the native places and especially capitalizing on them with their whole load of centuries in a vision. unique, complex, representative musician of Romanian choral music. Keywords: Jesus Christ, religion, church, Porumbescu, culture, choir, folklore, music, history "
The Character “Lucrezia Borgia” of Donizetti’s Homonymous Opera. An Analysis of Character and Vocal Features
Authors:   PhD Student, Faculty of Music, University of Transilvania, Brașov, Romania. Email: adetuedith@gmail.com., Adetu Edith Georgiana , Coroiu Petruța Maria ,   PhD Professor, Faculty of Music, University of Transilvania, Brașov, Romania. Email: maniutpetruta@yahoo.com.
Published: July 2022

"Donizetti’s opera “Lucrezia Borgia” presents one of the most complex female characters in the history of Italian lyrical theatre – a notable portrait of “femme fatale”. Based on Victor Hugo’s play, Gaetano Donizetti’s creation offers generous interpretation contexts, both from a vocal and a dramaturgic point of view. This article will deal with the particularities of Lucrezia Borgia’s role, underlining the importance of the relationship between vocality and dramaturgy, focusing on the analysis of the main soloist moments. Keywords: Lucrezia Borgia, Donizetti, character, typology, vocality "
Profil Kadar Natrium Serum pada Pemberian Manitol 20% dan Natrium Laktat Hipertonik Intravena pada Tikus Jantan Wistar
Authors:   Department of Anesthesiology and Intensive Care Faculty of Medicine Universitas Gadjah Mada Dr. Sardjito General Hospital Yogyakarta Indonesia, Pamillian Niko , Sudadi Sudadi
Published: July 2022

Background and Objective: Prolonged use of hyperosmolar solution associated with mortality. Hypertonic sodium lactate as a new sodium-based solution does not yet have an evidence base that states that long-term use is safe in increasing ICP. Knowing the effect of hypertonic sodium lactate on alterations sodium level in male wistar rats compared to mannitol Subject and Method: This research is an animal experimental laboratory study using a simple random sampling design.Thirtysix male wistar rats were obtained with age and body weight 14.22±0.43 weeks and 301.56±25.10gr in the group A and 14.17±0.38 weeks and 277.61±18.85gr in the group B. Both groups were given hypertonic sodium lactate or mannitol for 5 days and assessed on changes sodium level after administration. Results: The highest alterations sodium levels in the hypertonic sodium lactate group compared to mannitol occurred on the first day 5.06±4.25 compared to sodium levels before treatment 5.67±2.96 mEq / L (p = 0.222) and the lowest changes were obtained at the third day compared to the second day (0.22±3.51 vs 0.22±2.29 mEq / L) (p = 0.568). The highest mean in the hypertonic sodium lactate group compared to mannitol was 147.83±3.35 vs 147.83±3.35 mEq / L and the lowest mean was 145.83±2.07 vs 146.06±2.92. Conclusion: In this experimental animal study, hypertonic sodium lactate and mannitol increased sodium levels significantly compared to before treatment, but were not followed by significant changes on the first day to the fifth day.
Tatalaksana Anestesi Pasien Adenoma Hipofisis dengan Riwayat Hipotiroid
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Sriwijaya/Dr. M. Hoesin General Hospital Palembang Indonesia, Dewi Maharani Nurmala , Yulianti Bisri Dewi ,   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, Indonesia, Umar Nazaruddin
Published: July 2022

Pituitary adenoma is a brain tumor has clinical symptoms depending on hormones produced by tumor cells, size, and local invasion. A 50-year-old woman with pituitary adenoma with history of hypothyroidism. On preoperative, GCS E4M6V5, blood pressure was 114/76 mmHg, pulse was 81x/minute, respiration was 18x/minute, and saturation was 99%. On physical examination, body weight and the visual acuity in the right eye decreased. Examination of thyroid function suggests hypothyroidism before surgery, patient was treated with levothyroxine sodium 100 g per day tablets for 14 days until euthyroid. The next treatment was resection craniotomy of the pituitary adenoma. Premedicated with hydrocortisone 100 mg and midazolam 0.1 mg/kg body weight. Induction propofol 1 mg/kg body weight, fentanyl 2 µg/kg body weight, rocuronium 1 mg/kg body weight, lidocaine 1 mg/kg body weight and repeated doses of 0.5 mg/kg body weight propofol. Mannitol was given 0.5 mg/kgbw and dexamethasone 10 mg. Maintenance anesthesia with sevoflurane 0.5% and propofol 50-100 µg/kgbw/min. Postoperative the patient in the ICU was given dexmedetomidine 0.2 µg/kgbw/hour and steroid supplement day-1 was given 25 mg hydrocortisone every 12 hours. On day-2, 20 mg of hydrocortisone in the morning and 10 mg in the evening, then can be discontinued. The patient was admitted to the ICU for 3 days before moving to the ward. Perioperative management of pituitary adenoma with a history of hypothyroidism is optimizing preoperatively the patient reaches euthyroid, maintaining hemodynamics, optimizing cerebral oxygenation, preventing and treatment if there are complications.
Manajemen Anestesi Reseksi Tumor Cerebello-pontine Angle Vestibular Schwannoma dengan Posisi Lateral
Authors:   Department of Anesthesiology and Intensive Care, Faculty of Medicine Universitas Udayana/Sanglah General Hospital Bali Indonesia, Pramana Suarjaya I Putu , Paramartha Bagus , J Sutawan Ida Bagus Krisna , Surya Panji I Putu Agus
Published: July 2022

Cerebellopontine angle (CPA) tumors are the most common neoplasms in the posterior fossa, accounting for 5-10% of intracranial tumors. Most CPA tumors are benign, with over 85% being vestibular schwannoma (acoustic neuromas). The preferred treatment for symptomatic vestibular schwannoma has been surgical excision. Craniotomy for vestibular schwannoma resections in lateral position gave better surgical field exposure, but also posed increased risk of ventilation-perfusion mismatch and atelectasis of the dependent lung in lengthy surgery. A 25 years old woman, with loss of hearing function, disturbed sense of balance, left hemiplegia, difficulties to swallow, on magnetic resonance imaging (MRI) examination had solid lesion in the cerebello-pontine angle size 5,6 cm x 5 cm x 4.5 cm which is diagnosed as Cerebello-pontine angle vestibular schwannoma sinistra. Patient underwent surgical resection in right lateral position under general anesthesia and the surgical resection performed in 6 hour 40 minutes. The goals of anesthetic management in vestibular schwannoma tumor resection are to facilitate ideal surgical condition and provide brain protection by maintaining cerebral perfusion pressure, avoid hemodynamic instability, enable intraoperative neuro-monitoring and ensure the early detection and prompt management of potential complications.
Prototype of sliding whiteboard as physics learning media based on thinking processed review
Authors: Jesajas Marthen Billy , Rondonuwu Ferdy Semuel , Kristiyanto Wahyu Hari
Published: July 2022

Whiteboard is one of the learning medias used by the teacher in classroom. It has a great role in physics teaching and learning process. As media of learning, a whiteboard also has an important role in students’ thinking process. This paper discussed about the design of sliding whiteboard based on students’ assimilation of thinking in information processing that written on the whiteboard. The result of sliding whiteboard designs served as a prototype. The prototype was made from 10 cm x 18 cm plywood and rope as a slider. This prototype is expected to became an alternative model in addition to fix stage or theater seat model. In addition, the whiteboard sliding model will be accompanied by a module and user manual. Impact of the prototype on student learning was discussed.
Bioremediation of Pb and Cd contaminated soil using microorganism
Authors: Wulandari Andriyani Dea , Meitiniarti Vincentia Irene
Published: July 2022

The increase in industrial waste, especially those containing Pb and Cd, which is discharged into the environment results in more polluted environment conditions. Polluted enviornment is very dangerous for the survival of living things. This  technique use living things to reduce environmental pollution, making it safe for living things. Bioremediation can be carried out by in-situ and ex-situ methods with several bioremediation mechanisms, including biosorption, bioaccumulation, bioleaching, and bioprecipitation. The use ex-situ techniques in bioremediation is easier to do, especially if it is carried out to remediate soils under controlled conditions in the laboratory.
Irrigation Frequency and Volume has Little Influence on Phytophthora Root Rot in Container-grown Rhododendron
Authors: Weiland Jerry E. , Scagel Carolyn. F. , Grünwald Niklaus J. , Davis E. Anne , Beck Bryan R. , Mitchell Jesse N.
Published: July 2022

We evaluated whether reducing irrigation frequency and volume alters the ability of Phytophthora plurivora and P. cinnamomi to cause root rot on rhododendron grown in a noninfested potting medium or media infested with 1 or 100 propagules per gram (ppg) of pathogen. Plants were irrigated to maintain a substrate moisture of >70% container capacity (1.0X), one-half volume of 1.0X (0.5X), or two times the volume of 1.0X at each irrigation event for one week, followed by no irrigation, until soil moisture reached <50% container capacity. Aboveground disease symptoms (chlorosis, stomatal conductance, wilting, and plant death) were evaluated weekly and root rot, pathogen presence, plant biomass, and nutrient uptake were measured at the end of each trial. Both pathogens generally caused mild disease at 1 ppg and severe disease at 100 ppg. Reducing irrigation did little to lessen disease caused by either pathogen once infection had occurred. Instead, severe root infection often led to increased soil moisture and root rot across all irrigation treatments as roots became progressively compromised in their ability to take up water. Results show that reducing irrigation after infection has occurred is unlikely to effectively control root rot.

Species used in this study: Phytophthora species (Phytophthora cinnamomi Rands; Phytophthora plurivora T. Jung and T.I. Burgess); rhododendron, Rhododendron catawbiense Michx. ‘Album', ‘Roseum Elegans', and ‘Roseum Pink'.
An Analysis of the Quality of Compost Produced from Vermicomposting Fresh Cut Flower Waste
Authors: Etheredge Coleman L. , Waliczek Tina M.
Published: July 2022

Higher levels of pesticide applications are used when growing cut flowers when compared to other crops such as tomatoes, lettuce, and rice, much of the floriculture industry production occurs in developing countries where less environmental regulations may be in place compared to those in the United States. Therefore, special consideration should be given to cut flower disposal from floral shops due to the potential excessive leaching of pesticides into land and waterways. Most retail florists in the industry dispose of their floral waste into municipal dumpsters. There are an estimated 13,200 retail flower shop locations in the United States, comprised of single location and multiple location companies. While the United States Department of Agriculture (USDA) has stringent guidelines to prevent the importation of pests and plant diseases, there are no regulations on the disposal of spent floral crops that may contain residues of pesticides or other chemicals. Vermicomposting is a method of composting used for pollution abatement while having the added benefit of acting as an alternative waste management method to traditional landfill dumping. The castings produced are a valuable commodity for agricultural, horticultural, and related industries. The main objective of this research was to analyze the quality of compost produced from vermicomposting fresh cut floral waste. Analysis of results was based on the U.S. Composting Council's Tests Methods for the Examination of Composting and Compost used by the U.S. Composting Council's Seal of Testing Approval (STA) program. When compared to STA standards, pH, soluble salts, organic matter, total nitrogen, carbon, carbon-to-nitrogen, bioassay, and respirometry all were found to be within normal ranges for compost sold in the horticulture industry. Chemical analysis found the level of arsenic, cadmium, copper, lead, mercury, molybdenum, nickel, selenium, zinc all to be well below set industry standards. Additionally, the vermicompost was lab tested for 23 herbicides and insecticides. Of those, one herbicide (clopyralid) and two insecticides (clofentezine and lufenuron) were found in the sample in trace amounts, and well below Environmental Protection Agency (EPA) set industry standards for acceptable trace amount in U.S. products. Results indicated floral waste collected from retail flower shops can be incorporated into a vermicomposting system to create a quality compost suitable for use in the horticulture industry.
Modelo de impacto de redes sociales en atletas de un evento deportivo mediano
Authors: Einsle Carmen Sarah , Escalera Izquierdo Gregorio
Published: July 2022

El uso de las redes sociales (RRSS) como herramienta de marketing está en constante auge tanto en el sector deportivo como en el turístico. Para poder aprovecharse de los beneficios que pueden brindar estos medios es importante conocer el impacto generado por las RRSS. El objetivo de este estudio fue el análisis del impacto de las RRSS en los participantes en un evento deportivo mediano. La muestra fue compuesta de 254 atletas de la carrera Benidorm Half. Los resultados del análisis factorial exploratorio (AFE) y del análisis factorial confirmatorio (AFC) mostraron índices de ajuste, una validez discriminante y una fiabilidad satisfactorios. Los resultados permitieron identificar tres factores que miden el impacto de las RRSS entre los participantes. Se comprobó una influencia significativa del valor percibido en RRSS en el eWOM. El factor de información adicional también influyó significativamente en el valor percibido en RRSS.
Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology
Authors: Mancini Shelby L. , Early Peter J. , Slater Bailey M. , Olby Natasha J. , Mariani Christopher L. , Munana Karen R. , Woelfel Christian W. , Schacher Jordan A. , Zhong Li , Messenger Kristen M.
Published: July 2022

OBJECTIVE

To investigate the feasibility and pharmacokinetics of cytarabine delivery as a subcutaneous continuous-rate infusion with the Omnipod system.

ANIMALS

6 client-owned dogs diagnosed with meningoencephalomyelitis of unknown etiology were enrolled through the North Carolina State University Veterinary Hospital.

PROCEDURES

Cytarabine was delivered at a rate of 50 mg/m2/hour as an SC continuous-rate infusion over 8 hours using the Omnipod system. Plasma samples were collected at 0, 4, 6, 8, 10, 12, and 14 hours after initiation of the infusion. Plasma cytarabine concentrations were measured by high-pressure liquid chromatography. A nonlinear mixed-effects approach generated population pharmacokinetic parameter estimates.

RESULTS

The mean peak plasma concentration (Cmax) was 7,510 ng/mL (range, 5,040 to 9,690 ng/mL; SD, 1,912.41 ng/mL), average time to Cmax was 7 hours (range, 4 to 8 hours; SD, 1.67 hours), terminal half-life was 1.13 hours (SD, 0.29 hour), and the mean area under the curve was 52,996.82 hours X μg/mL (range, 35,963.67 to 71,848.37 hours X μg/mL; SD, 12,960.90 hours X μg/mL). Cmax concentrations for all dogs were more than 1,000 ng/mL (1.0 μg/mL) at the 4-, 6-, 8-, and 10-hour time points.

CLINICAL RELEVANCE

An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cytarabine and a Cmax of 7,510 ng/mL (range, 5,040 to 9,690 ng/mL; SD, 1,912.41 ng/mL). These are comparable to values reported previously with IV continuous-rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology.
A Study on Image Processing Using Artificial Neural Networks in Civil Engineering
Authors: Andon Alexandrina-Elena , Covatariu Gabriela
Published: July 2022

For the last five years, image processing using artificial neural networks (ANN) got several researchers interested in the field of Civil Engineering. As the artificial neural network, which consists of several neurons may not be able to extract features from the image due to the required computing power, the Convolutional Neural Network (CNN) was created. CNN is a machine learning algorithm that uses the image as input, attributing the importance of different aspects (objects in the image) to allow their differentiation. The results recorded in Civil Engineering domain show a real success.
Capsanthin induces death in human prostate cancer cell lines by inducing DNA damage
Authors: Eraslan Ersen , Erden Yavuz , Oruc Sinem , Bircan Burak , Gunay Sevilay
Published: July 2022

There is a relationship between a person’s diet and the development and prevention of some cancers. Carotenoids are found as various natural pigments in many fruits and vegetables. Studies on carotenoids and their potential roles in carcinogenesis are increasing in importance day by day. In this study, we aimed to determine the cytotoxic and genotoxic effects of capsanthin, a carotenoid compound, in human prostate cancer cell lines.

After different concentrations of capsanthin were applied to human prostate cancer cell lines (LNCaP and PC-3), the effects of the compound on cell viability were determined by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test. The single-cell gel electrophoresis (Comet) assay was then used to reveal the genotoxic effects of probable cytotoxic dosages on cell DNA. After the treatments, apoptotic cell death levels were determined by Tunel staining. At high concentrations, capsanthin dramatically reduced PC-3 and LNCaP cell viability (p<0.05). In addition, capsanthin caused DNA damage and apoptotic cell death in the prostate cancer cells. The results show that capsanthin reduces cell viability by causing genotoxicity in prostate cancer cells.
A Comprehensive Assessment of The Eight Vital Signs
Authors: Draves J , Tekiner H , Yale ES , Mazza JJ , Yale SH
Published: July 2022

The term “vital sign” has been assigned to various phenomena with the presumptive intent to emphasize their importance in health care resulting in the emergence of eight vital signs with multiple designations and overlapping terms. This review developed a case definition for vital signs and identified and described the fifth through eighth vital signs. PubMed/Medline, Google and biographical databases were searched using the individual Medical Subject Headings (MeSH) terms, vital sign and fifth, vital sign and sixth, vital sign and seventh, and vital sign eighth. The search was limited to human clinical studies written in English literature from 1957 up until November 30, 2021. Excluded were articles containing the term vital sign if used alone without the qualifier fifth, sixth, seventh, or eighth or about temperature, blood pressure, pulse, and respiratory rate. One hundred ninety-six articles (122 for the fifth vital sign, 71 for the sixth vital sign, two for the seventh vital sign, and one for the eighth vital sign) constituted the final dataset. The vital signs consisted of 35 terms, classified into 17 categories compromising 186 unique papers for each primary authored article with redundant numbered vital signs for glucose, weight, body mass index, and medication compliance. Eleven terms have been named the fifth vital sign, 25 the sixth vital sign, three the seventh, and one as the eighth vital sign. There are four time-honored vital signs based on the case definition, and they represent an objective bedside measurement obtained noninvasively that is essential for life. Based on this case definition, pulse oximetry qualifies as the fifth while end-tidal CO2 and cardiac output as the sixth. Thus, these terms have been misappropriated 31 times. Although important to emphasize in patient care, the remainder are not vital signs and should not be construed in this manner.
Mucormycosis in COVID-19 patients with uncontrolled diabetes – the lethal triangle
Authors: Neagu Mihaela , Badea Carmen , Tanase Ionut
Published: July 2022

BACKGROUND. Coronavirus disease 2019 (COVID-19) is one of the main global health problems of the twenty-first century, with more than one-hundred million people infected and more than two million deaths. The immunosuppression caused by SARS-CoV-2 infection along with steroidal treatment, hyperglycaemia and elevated ferritin levels creates the perfect environment for opportunistic infections such as mucormycosis. COVID-19-associated mucormycosis carries a high mortality rate. Therefore, in addition to antifungal therapy and aggressive surgical debridement of necrotic tissue, strategies to improve glycaemic index is the key factor in order to obtain a favourable outcome.

MATERIAL AND METHODS. For the purpose of this article, the PubMed databases were searched using MeSH descriptors and the Boolean operator “AND” for the terms “rhinosinusal” and “mucormycosis” and “diabetes”, between February 2019 – December 2021. Clinical characteristics, therapy and outcome data were gathered and compared to what has previously been reported in the literature. Also, we report the case of a 68-year-old patient with uncontrolled type 2 diabetes mellitus, who developed mucormycosis during post-COVID period, to underline the need of early detection of this potentially deadly fungal illness.

RESULTS. The clinical and imaging evaluation revealed no evidence of disease recurrence, at one- and two-months’ follow-ups.

CONCLUSION. In this context, we would like to emphasize the importance of a high index of suspicion for mucormycosis in patients with COVID-19 infection, with pre-existing medical disorders, presenting with rhino-orbital or rhino-cerebral symptomatology.