bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and G-Quadruplex-binding Properties of Cationic Platinum(II) Terpyridine Complexes Containing σ-Alkynyl Auxiliaries
Authors: Ou Zhize , Feng Zhao , Liu Guixia , Chen Yongjie , Gao Yunyan , Li Yi , Wang Xuesong
Published: December 2014

The cationic alkynylplatinum(II) terpyridine complexes show high affinity (Ka > 107 M−1) and reasonable selectivity for telomeric and c-myc G-quadruplexes over duplex DNA. In the absence of alkali cations, these Pt(II) complexes can promote the formation and stabilization of G-quadruplexes. The cytotoxicity of complexes 2 and 3 against the A549 cancer cell line is ca. 25-fold and 35-fold higher than that of cisplatin, respectively.
Maltopentaose-conjugated Thermoresponsive Block Copolymer: Precision Synthesis through RAFT Polymerization of N,N-Diethylacrylamide
Authors: Togashi Daichi , Otsuka Issei , Borsali Redouane , Kawaguchi Seigou , Narumi Atsushi
Published: December 2014

A strategy to directly prepare maltopentaose-block-poly(N,N-diethylacrylamide), Mal5-block-PDEAA, based on the reversible addition–fragmentation chain-transfer (RAFT) polymerization technique as a metal-free process is described. Mal5-block-PDEAA generated stable nanoaggregates in water with an average hydrodynamic radius (Rh) of 109 nm by heating to around the human body temperature; thus, the present strategy is useful for the preparation of polymers for biomedical applications.
Thermal Behavior of Amphiphilic Calix[4]resorcinarene in the Presence of Silica Nanoparticles
Authors: Yamagishi Tada-aki , Nakazumi Yoshihiro , Tsukamoto Masaya , Ogoshi Tomoki , Yoshimura Yukio
Published: December 2014

We have reported the interaction between the amphiphilic calix[4]resorcinarene CR(10) and silica nanoparticles by the analysis of the hydrogen bonding and melting behavior of CR(10). Amphiphilic CR(10) readily formed an aggregation state with a micro-phase-separation structure, and was possible to show higher thermal stability in the presence of silica nanoparticles.
One-step Electronic Monitoring of Tetracycline Residue within 5 min Based on the Competitive Displacement Reaction between the Antigen and Pseudo Hapten for the Target Antibody
Authors: Lou Fangming , Li Qunfang , Tang Dianping
Published: December 2014

A simple and sensitive electrochemical immunosensing protocol was developed for the fast screening of tetracycline residue, within 5 min, based on the competitive-type displacement reaction between the antigen and pseudo hapten for the antibody.
Iron-catalyzed Suzuki–Miyaura Coupling Reaction of Unactivated Alkyl Halides with Lithium Alkynylborates
Authors: Nakagawa Naohisa , Hatakeyama Takuji , Nakamura Masaharu
Published: December 2014

A Suzuki–Miyaura coupling reaction between unactivated alkyl halides and lithium alkynylborates was performed using an iron–bisphosphine catalyst. The reaction shows high chemoselectivity and is applicable to a broad scope of substrates bearing electrophilic functional groups. A radical probe experiment using cyclopropylmethyl bromide was conducted to investigate the nature of the intermediate in the reaction, showing that an alkyl radical species is generated from the alkyl halide substrate.
Business Corporations in the New Version of the Russian Civil Code
Authors: Sukhanov Evgeniy
Published: December 2014

The reform of the Russian civil legislation is far from being completed. A new wording of Chapter 4 of the Civil Code of the Russian Federation is an important, but by no means final milestone of transformation of the civil legislation launched in the Russian Federation. The author considers reasons and legal consequences of enshrining in the legislation of companies’ classification into public and non-public, atypical versions of business entities (special-purpose company, joint-stock company of employees), identifies Russian corporate law development trends. Besides, the author demonstrates a negative influence of Anglo-American approaches to the Russian legal system, different understanding of basic legislative and doctrinal structures of the corporate law in continental and Anglo-American legal families. As a result, the author substantiates impossibility of isolated and chaotic adoption of legislative solutions from a foreign legal system built on different legal regulation principles. However, the articles makes a reservation stating that entrepreneurial corporations under Russian law should not be understood as a synonym of business entities, and the corporate law is not an element of contractual law, but a sub-branch of Russian civil law.
Social Responsibility of Business: Legal Aspects of the Economic Concept
Authors: Nurtdinova Aliya
Published: December 2014

The article deals with the problem of creation of the business (corporative) social responsibility conception and key elements of this conception. The functioning of the market economy in the modern society is impossible without strong ties between society and business community, social obligations of companies, corporations, firms and so on. Idea of business (corporative) social responsibility reflects these ties and is based on the philosophical doctrine of moral ideals as the goal of social progress. Business (corporative) social responsibility supposes free-will initiatory social activity of companies — activity, that is not related to commercialization. There are some areas of such activity: occupational safety, providing favourable conditions of employment, protection the environment, social security, health protection, culture and education. The author has attempted to characterize principles of companies’ social activity. These are: respect for law order, which means not only subjection to the law, but voluntary renunciation of using deficiencies of law and other law imperfections; respect for international laws; respect for human rights; concerning for moral ideals. Companies realize social responsibility in different ways. First of all through collective bargaining procedure. The next way is cooperation with government and local communities. Cooperation with non-government organizations (civil society organizations) and charity are also possible.
Interests of Business in the Conditions of the Reform of Civil Legislation on Rights in Rem
Authors: Emelkina Irina
Published: December 2014

The article discusses the problems faced by Russian entrepreneurs in the implementation of land rights. The author notes that in the transition to a new system of limited real rights must take into account the interest of business. Particular attention is paid to the analysis proposed for the introduction of the Civil Code of the Russian Federation, the two property rights to land, buildings and permanent tenure. The article highlights the prospects of these rights, noted shortcomings of the bill to amend the Civil Code of the Russian Federation, the legal model proposed legislated specified rights in rem.
Criminal Responsibility of Legal Persons for Corruption-Related Crimes
Authors: Fedorov Aleksandr
Published: December 2014

The article substantiates the author’s conclusion to the effect that the introduction of criminal liability of legal entities is a forecast tendency of Russian criminal law policy development, and exposes objective grounds for introducing such a liability. It points out that criminal responsibility of bodies corporate is established in many countries and required by international obligations of the Russian Federation. The article contains data on the charging of legal entities in the Russian Federation with an administrative offence of illegal gratuity on behalf of a legal entity (Article 19.28 of the Code of Administrative Offences of the Russian Federation) and formulates reasons pointing out the insufficient effectiveness of the existing institution of legal persons’ administrative liability for acts of that type.
Purpose of Creation as an Element of the Legal Regime of the Federal Information System
Authors: Amelin Roman
Published: December 2014

The article considers the problem of unification of legislation that establishes the legal regime of Federal information systems. The purpose of the information system is a necessary element of its legal regime. It is primary to other elements, such as lists of information, the functionality of the system, the rights and obligations of users, information providers and the system operator. The author believes that it is impossible to establish in law the duties of citizens and organizations (such as the provision of information) that are not defined by purpose of creation of the federal information system. The author analyzes the current Federal laws on information systems, compares approaches to legal regulation of creation purposes. It is proved that the purpose of creation is to be associated with public services and government functions.
Interactive Forms of Societal Control over the Activities of State Authorities in the Constituent Entities of the Russian Federation
Authors: Lapshina Arina
Published: December 2014

The article is devoted to the analysis of interactive forms of public control over the activities of public authorities in subjects of the Russian Federation and analysis of the main problems of their realization. The author comes to a conclusion that the efficiency of the public control in the interactive forms based on activity of subjects of the Russian Federation on building dialogue with citizens, on the use of modern information technologies, as well as on the willingness of the society to participate in the decision-making for State. The author proposes to continue the work on the automation of the processes of realization of public control, to expand the range of public actions of public authorities in subjects of the Russian Federation, in the case of it is possible to conduct control in interactive forms, to construct mechanisms of monitor the activities of public authorities of subjects of the Russian Federation on the problems solving during the process of public control, to guarantee a opportunity of assessment of the citizens timely "response" of the government on such problems.
Is It Me or Her? How Gender Composition Evokes Interpersonally Sensitive Behavior on Collaborative Cross-Boundary Projects
Authors: Williams Michele , Polman Evan
Published: December 2014

This paper investigates how professional workers’ willingness to act with interpersonal sensitivity is influenced by the gender and power of their interaction partners. We call into question the idea that mixed-gender interactions involve more interpersonal sensitivity than all-male interactions primarily because women demonstrate more interpersonal sensitivity than do men. Rather, we argue that the social category “women” can evoke more sensitive behavior from others such that men as well as women contribute to an increase in sensitivity in mixed-gender interactions. We further argue that the presence of women may trigger increased sensitivity such that men can also be the recipients of more sensitivity when one or more women are present on a team. In a study of 202 management consultants, we found that the willingness to act with interpersonal sensitivity increased in interactions with women. Moreover, this effect was greater in interactions with women who had low reward power—i.e., females who better fit the expectations associated with the social category “women.” We also found team-level effects. Professionals working with mixed-gender versus all-male client teams reported a greater willingness to act with interpersonally sensitive behavior toward male client team members. Our findings show that the willingness to act with interpersonal sensitivity is context dependent and shed light on the importance of studying interaction partner-level and team-level effects on willingness to act with interpersonal sensitivity.
Being a Catalyst of Innovation: The Role of Knowledge Diversity and Network Closure
Authors: Tortoriello Marco , McEvily Bill , Krackhardt David
Published: December 2014

Whereas recent research on organizational innovation suggests that there is an ecology of roles supporting the innovation process, the majority of network research has concentrated on the role of inventors. In this paper, we contribute to research on organizational innovation by studying the social structural conditions conducive to individuals supporting, facilitating, and promoting the innovativeness of their colleagues—a role we refer to as catalysts of innovation. We consider an individual’s network position and the type of knowledge available to her through her network as key enabling conditions. We argue that the unique configuration of having access to diverse knowledge through a closed network enables individuals to act as innovation catalysts. Based on a study of 276 researchers in the research and development division of a large multinational high-tech company, we find strong support for our prediction and demonstrate that catalysts make important contributions to the innovative outputs of other researchers in terms of their colleagues’ patent applications.
Anaemia and iron deficiency in systolic heart failure
Authors: O'Donovan Kate
Published: December 2014

Heart failure is associated with symptoms of fatigue, poor quality of life and reduced exercise tolerance. One of the contributing factors to these symptoms is iron deficiency, which is present in up to one-third of patients with heart failure. The cause is complex and multifactorial, and is perceived as the initial step in developing anaemia. Randomised controlled trials have demonstrated the benefit of intravenous iron supplementation in reducing symptoms and improving exercise tolerance and quality of life, in addition to improving serum parameters and reducing inflammatory markers. Adverse effects reported in trials include pain at the injection site and injection site discolouration. No serious adverse effects were reported. There are generally no acceptable recommendations for clinical practice but intravenous iron supplementation is advocated in European and international guidelines for patients with heart failure. Routine screening for iron deficiency in this patient population is advocated, with the aim of treating any identified deficiency in a prompt manner in order to maintain functional capacity and quality of life.
Understanding illness perception as a barrier to cardiac rehabilitation uptake
Authors: Conway Barbara
Published: December 2014

This is an exploration of some of the evidence that supports the notion that negative illness perceptions are a barrier to accessing cardiac rehabilitation services for people with heart disease. The evidence that exists and potential strategies to improve the issue will be explored. It is hoped that ideas for future service development can be recommended. Cardiac rehabilitation is a cost-effective service that offers people with heart disease a structured programme of care. Given the evidence that shows the effectiveness of cardiac rehabilitation, health professionals need to be aware of the barriers that exist so that services can be improved for patients, ensuring that they are tailor made, menu-based and patient driven.
Nurses' knowledge and practice regarding implantable cardiac devices in Egypt
Authors: Ali Nahla Shaaban , Youssef Warda , Mohamed Abdo , Hussein Ali
Published: December 2014

Background

Patients with implanted cardiac devices constitute a growing segment of contemporary health practice. Nurses have a unique role providing care in hospitals, long-term health care, education and psychological support to these patients.

Aim

To assess critical care nurses' knowledge and practice regarding implantable cardiac devices.

Research design

A descriptive exploratory design used the following research questions: (a) What is the nurses' knowledge level regarding implantable cardiac devices? (b) How do nurses manage patients with implantable cardiac devices?

Setting

At selected critical and coronary care units in Egypt.

Sample

A convenience sample of 40 nurses with a minimum 1 year of experience was included in the study. Tools for data collection: Tool 1: background data that included gender, age, educational level, area of work and years of experience. Tool 2: questionnaire to assess nurses' knowledge regarding implantable cardiac devices. Tool 3: implantable cardiac devices observational checklist to assess nurses' practice when caring for patients who are being fitted with implantable cardiac devices.

Results

The current findings revealed that nurses have low knowledge and practice scores and no significant correlations existed between gender, age, years of experience, and their level of knowledge and practice, except negative correlation which existed between practice and years of experience regarding implantable cardiac devices.

Conclusion

Critical care nurses have inadequate knowledge and practice regarding implantable cardiac devices.

Recommendations

Replication of this study on a larger probability sample from the different geographical locations of the Arab Republic of Egypt and further research to explore why nurses do not have the knowledge or skills regarding implantable cardiac devices.
Rivaroxaban—a safe alternative to warfarin in atrial fibrillation cardioversion
Authors: Cedron Diana , Farag Mohamed , Gorog Diana A
Published: December 2014

Diana Cedron, Mohamed Farag and Diana A Gorog provide an overview of the findings of the X-VeRT study and how these could affect clinical practice
ECG of the month
Authors: Regan Claire , Regan Martin
Published: December 2014

Claire Regan and Martin Regan present an ECG for you to analyse
Prescribing practice of take-home analgesia for day case surgery
Authors: Lewin Janet ME , Razis Platon A
Published: December 2014

Postoperative pain following day surgery is a common problem. The prescription of appropriate analgesia with clear instructions for the patient is crucial. This article examines the effect of changing prescribing practice, backed up by a patient information leaflet, on the effectiveness of take-home analgesia after day case surgery.
The future of mental health nurses in liaison psychiatry
Authors: Regel Stephen , Davies John
Published: December 2014

This article examines the current status of the mental health nurse in liaison psychiatry. A model for practice is put forward and the need for a cohesive educational framework is argued.
Intermittent self-catheterisation: research-based practice
Authors: Moore Katherine N
Published: December 2014

Intermittent self-catheterisation (ISC) is an effective management strategy for people who have urinary retention or postvoid residual due to urethral sphincter or detrusor dysfunction. However, some questions still need to be answered on the details of ISC. This article presents current research findings that may resolve some of the practice issues and suggests that nurses are in a prime position to implement research-based practice.
Children's views about health: assessing the implications for nurses
Authors: Chevannes Mel
Published: December 2014

This article explores how children, in interacting with parents, peers and others, acquire their beliefs about health and health-related matters and examines children's lay health beliefs of the importance of ethnicity in structuring their views. These themes are developed in interviews with children about health and health-related matters. The views which emerge are discussed in relation to their implications for nurses.
Don't drink and nurse: alcohol abuse in nursing
Authors: Castledine George
Published: December 2014

Drinking alcohol on duty, or before going on duty, is not an offence but it may lead to professional misconduct. The UKCC states that the nurse should act:

‘… at all times, in such a manner as to: serve the interests of society; justify pu blic trust and confidence; and uphold and enhance the good standing and repu ta tion of the profession’ (UKCC, 1992).
Effect of patient education on asthma management
Authors: Brewin Adrienne M , Hughes John A
Published: December 2014

If asthmatic patients are to take an active part in controlling their own asthma, trained asthma staff must allow them sufficient time to learn self-management effectively.
The experience of advocacy
Authors: McNally Steve
Published: December 2014

This article explores the concept of advocacy and its relationship to the empowerment of service users. Forms of advocacy are described and their potential applications in practice are discussed. The practice implications for nurses and carers of vulnerable client groups are considered. A subsequent article will examine the process and outcomes of self-advocacy from the perspective of a group member with a learning disability.
The support of the family within the acute clinical area
Authors: Adam Joan
Published: December 2014

In the last 20 years the hospice movement has spread its philosophy, promoting the quality of life for dying patients and their families. The result is an improvement in the management of pain and other symptoms of distress in dying patients in acute hospitals. There has been extensive research into the psychological needs of the dying and their relatives. Palliative care has been included in the pre-registration curriculum for several years. Yet there is little evidence that the needs and stresses of the family are being met, considering the social and cultural variables that exist in today's society.
Specialisation in nursing comes of age
Authors: Castledine George
Published: December 2014

This is a significant year in the campaign for the recognition of specialist and advanced nursing practice.
Proactivity in VTE prevention: a concept analysis
Authors: Adams Averil
Published: December 2014

Venous thromboembolism (VTE) prevention is an international patient safety issue. The author has observed gaps in prescription and provision of VTE prophylaxis, and that the attitude to VTE is often reactive rather than proactive. This concept analysis aims to explore proactivity and apply it to VTE prevention to address this. Ten databases were searched (1992-2012) using the keywords proactive, proactivity, nurse, nursing, VTE/venous thromboembolism, prevent/prevention/preventing, behaviour, DVT/PE (deep vein thrombosis, pulmonary embolism). The Walker and Avant (2010) method of concept analysis identified the defining attributes as personal initiative, taking charge and feedback-seeking behaviour. Antecedents and consequences have been identified, and empirical referents are demonstrated. Defining proactivity in VTE prevention has the potential to increase prescription and, crucially, provision of prophylaxis, thereby improving patient care, reducing avoidable harm and improving the patient experience.
Newly qualified nurses' experiences of a preceptorship
Authors: Lewis Salliann , McGowan Brian
Published: December 2014

Research Question:

What was the experience of preceptorship like for newly qualified registered nurses in a healthcare trust?

Method:

A qualitative approach was used with data collected using semi-structured one-to-one interviews with eight participants who had recently completed their preceptorship period. The data was analysed using Newell and Burnard's (2011) Pragmatic Approach to Qualitative Data Analysis, which involved a six-stage analysis process.

Findings:

Two main categories emerged from the data. These were Support Requirements and Expectations of Preceptorship. Support was further broken down into two themes: time and build confidence. Expectations of preceptorship was further broken down into two themes; understanding the process and understanding the preceptor's role.

Conclusion:

The participants felt that preceptorship offered support and helped them in developing their confidence in the transition to registrant. It would appear that consistency of provision of preceptorship is a key issue that would warrant further study.
Best interests of adults who lack capacity part 2: key considerations
Authors: Griffith Richard
Published: December 2014

Last month's article discussed the key concepts underpinning the notion of best interests. In this article the author discusses the requirements for determining the best interests of an adult who lacks capacity under the provisions of the Mental Capacity Act 2005 and its code of practice ( Department for Constitutional Affairs 2007 ).
Mentorship part 1: the role in the learning environment
Authors: Vinales James Jude
Published: December 2014

Mentors play a vital role in the education of preregistration nursing students. Because the learning environments in which the students are placed are crucial for the development of the future workforce, it could be argued that mentors are the ‘gatekeepers’ of the nursing profession. However, the mentor's role is not an easy one and, with the added pressures of modern health care, there appear to be greater demands placed on nurses, which in turn affect the mentor's role. This article will be the first in a series of five looking at aspects of the mentor and the mentor's role in practice. This first article will focus on the mentor and the role of the mentor in practice, together with the identification of ‘toxic mentors’, who can hinder learning in the clinical environment. It is in working together with the mentor that students will learn the true nature of nursing from a ‘hands-on’ perspective, applying in practice the knowledge learned in class.
NHS hospital complaints: are we still going round in circles?
Authors: Tingle John
Published: December 2014

In the second part of his two-part column John Tingle discusses the report published by the Patients Association on the state of the NHS Complaints system
Management of occupational blood exposures: looking at progress
Authors: Flynn Mairead Holland , Reid Alex
Published: December 2014

Occupational blood exposure (OBE) is a well-recognised hazard in the healthcare setting. A 4-year review of OBE in a large Irish teaching hospital over 2008–2011 found encouraging results, but identified deficits in documentation, communication and follow-up. The process was repeated 1 year later to determine if improvements were achieved and recommendations implemented. In 2012, 110 OBEs were reported, of which 81% were reported within 72 hours of the injury. The administration of first aid was adequately documented in 85% of cases and confirmation of the provision of appropriate information and/or counselling in 72% of the cases. Attendance for follow-up was broadly in line with the previous review. The findings and recommendations contributed to improvements in practice. However, to ensure these are ongoing, the reinforcement of an educational strategy in a systematic way is fundamental.
Celebration caps a landmark year
Authors: Gilchrist Amanda ,   Disgruntled
Published: December 2014

MA Education Ltd, St Jude's Church, Dulwich Road, London, SE24 0PB. neil.henty@markallengroup.com
Reviewing integration
Authors: Allingham Sue
Published: December 2014

The idea of bringing together health and education reviews for two-year-olds has been on the cards for some time. So what are the challenges to making this important holistic intervention tool a reality?
Thinking scientifically
Authors: Rich Diane
Published: December 2014

What does it mean to think scientifically? How can thinking this way help children to understand the world? What matters to children when they make sense of the world? What does it mean for educators?
Focusing on family care
Authors: Longley Maureen
Published: December 2014

Maureen Longley explores the implications of the extended Troubled Families programme for those working in the early years and how collaborative working can provide desired outcomes for children.
Starting to bear fruit
Authors: Francis-Pester Dawn
Published: December 2014

The RNIB's The Orchard nursery seems ahead of the game in supporting children with a range of educational needs. Here, we find out how they are encouraging development in inspirational ways.
Losing someone special
Authors: Brown Paula
Published: December 2014

It is always hard to talk about, often personal and can affect us in different ways, but it is an unfortunate fact that bereavement affects most children and staff and we need to know how best we can help them.
The importance of attachment for disadvantaged two-year-olds
Authors: Read Veronica
Published: December 2014

What does good enough emotional support look like for a disadvantaged two-year-old and why do attachment relationships matter for all two-year-olds? We look at what this means for your provision.
Gold standard for childcare
Authors: Lawson Deborah
Published: December 2014

There has been growing concern and confusing recently that the esteemed NNEB qualification was no longer considered a relevant Level 3 qualification, reports that thankfully have proved inaccurate.
What we can learn from…: Love!
Authors: Chapman Ailsa
Published: December 2014

February contains Valentine's Day, a celebration of love. Older children may well be aware of the cards and flowers, and gifts, and it is an ideal opportunity to explore feelings and wellbeing.
Seven larks on a branch
Authors: Rivolta Heidi
Published: December 2014

This short series of articles will focus on incorporating simple and fun French hand rhymes into your regular setting routine. This month, we are using a counting song, called Sept Alouettes [Seven Larks].
Rumpus and roar galore
Authors: Sargent Marianne
Published: December 2014

Most children will love dinosaurs, whether in a book, as fossils, in museums or in cartoons. They are the perfect topic and resource for endless outdoor activities that can easily be linked to all areas of learning.
Everything in its place
Authors: Harries Judith
Published: December 2014

This is the fourth in a series of articles that uses practical activities based on the expressive arts, such as music, song and dance, to develop young children's skills in the mathematics area of early learning.
The effectiveness of training in the Parent-Infant Interaction Observation Scale for health visitors
Authors: Svanberg P.O. , Barlow Jane
Published: December 2014

Background

Sensitive responsiveness in parent-infant interaction is a significant predictor of infant emotional regulation, and attachment security. Health visitors play a key role in supporting such interaction, and in identifying parent-infant dyads in need of additional intervention as part of the Healthy Child Programme.

Aims

To examine the accuracy of a group of health visitors who have received no training in assessing parent-infant interaction, and whether this accuracy increases following training in the implementation of a newly developed screening tool, the Parent-Infant Interaction Observation Scale (PIIOS).

Method

A group of 10 health visitors rated 7 video clips before a 2-day training programme about using the PIIOS. The participants rated a further 7 videos following the completion of the training. Accuracy of rating pre and post training was assessed using Spearmans Rho correlation coefficients.

Results

The accuracy of the ratings for each of the health visitors ranged from 0.38–0.91, with 66% obtaining correlation coefficients of less than 0.80. In the post-training there was a significant increase (p<0.05) in the accuracy of the ratings, with 99% of participants scoring above 0.80 (ranging from 0.67–0.96).

Conclusions

The research confirms the findings of early studies which identified that without training, health visitors have a low accuracy in assessing parent-infant interaction, and following the delivery of a 2-day workshop in the use of a simple screening tool, accuracy improved significantly. All health visitors would benefit from training in the assessment of parent-infant interaction.
Watch your money grow
Authors: Aitken Liz
Published: December 2014

With new plans to establish savings clubs in primary schools, now is a good time to begin teaching children about money - where it comes from and how it works.
On the right track
Authors: Davis John
Published: December 2014

Find out about the materials created by Macintosh, Dunlop and McAdam. Two of these became new words in the dictionary while the other became a global brand.
With rhyme and reason
Authors: Williams Brenda
Published: December 2014

Poetry is a wide-ranging yet concise form of communication, with many styles and purposes. Brenda Williams' poems are explored here to unlock form and meaning.
Fast forward with the Fibonacci Sequence
Authors: Davis John
Published: December 2014

Use these activities to help pupils get to grips with binary code and the Fibonacci number series, which will open up an understanding of mathematical patterns.
Use Funny Bones to link literacy and science
Authors: Hewson Claire
Published: December 2014

Popular picture book Funny Bones can be the springboard for some lively activities in which children get to grips with the human skeleton and find out how it works.
Be attuned to your group
Authors: Cartwright Eva
Published: December 2014

TAs need to understand the importance of planning and preparation, effective delivery of teaching and evaluation of lessons, in order to manage groups effectively.
Investing in the future
Authors: Keates Chris
Published: December 2014

Achieving well in your first year of teaching can make all the difference to how your career progresses. It is all about a high quality experience, says Chris Keates.
How to stay on top
Authors: Stanley Julian
Published: December 2014

Every year, the Teacher Support Network helpline is inundated with calls from NQTs struggling to cope. Here Julian Stanley provides some practical advice.
Take your next step up to meet the spring term
Authors: Adams Margaret
Published: December 2014

How do you feel now you are in your second term in teaching? If you are objective when evaluating your progress you will be sure to have a spring in your step.
More than a snapshot
Authors: Lepkowska Dorothy
Published: December 2014

Star Testing, which uses a knowledge-based computer programme, is ‘teacher neutral’ and has proved highly effective for one school over the last decade.
Treatment with MG-132 and TSA induced apoptosis in OS-RC-2 cells by increasing oxidative stress and decreasing the expression of NF- kappa B
Authors: XU MIQING , XIE HUI , ZHONG YUN , MA JUNJIAN , LIU SHIMING , YANG HUI
Published: December 2014

Abstract. Xu M, Xie H, Zhong Y, Ma J, Liu S, Yang H. 2015. Treatment with MG-132 and TSA induced apoptosis in OS-RC-2 cells by increasing oxidative stress and decreasing the expression of NF-kappa B. Nusantara Bioscience 7: 20-25. Here we assessed the effect of the proteasome inhibitor MG-132 alone or in combination with the histone deacetylase inhibitor TSA on human renal cell on human renal cell carcinoma cells in vitro and we explored the underlying molecular mechanisms.OS-RC-2 cells were treated byMG-132 alone or in combination with TSA and/or NAc. The MTT assay and flow cytometry (FCM) were used to determine cell viability, ROS levels, and apoptosis. Expression of Bax and NF-kappa B p65 proteins was quantified by Western blotting. MG-132significantly increased the level of ROS, inhibited cell growth and induced apoptosis in a dose- and time-dependent manner. Both ROS and apoptosis were further increased following the combined addition of MG132 and TSA. In all cases, expression of p65 was down-regulated. MG-132 alone or in combination with TSA induced apoptosis in OS-RC-2 cells through the generation of ROS and the down-regulation of p65 expression.
Utilization of clinical practice guidelines: a survey of Canadian pediatric physicians
Authors: Nasir Fareeha , Nicholson Katharine , Vandermeer Ben , Kumar Manoj , Robinson Joan
Published: December 2014

Background: It is not clear how physicians currently use clinical practice guidelines (CPGs).Objectives: The objective was to describe how Canadian pediatric residents and pediatricians use CPGs and to identify barriers to CPG use.Methods: Pediatric emergency physicians and general pediatricians in Edmonton and Ottawa and all Canadian pediatric residents were surveyed regarding patterns of use for CPGs and barriers to use.Â Results: Response rate was 178/847 (21%).Â  The majority of responding residents (62%), emergency physicians (54%) and general pediatricians teaching more than 6 weeks annually on a clinical teaching unit (CTU) use CPGs at least monthly (55%) with less frequent use by pediatricians who teach 1 to 6 weeks on CTU (14%) or rarely/never teach on CTU (21%) (p<0.001). Canadian physicians are more likely to read Canadian Paediatric Society guidelines when they are published versus referring to them later when dealing with clinical problems while the opposite appears to be true for American Academy of Pediatrics guidelines. The most common barrier to use of guidelines is forgetting that a guideline exists for a specific problem. The majority of physicians access CPGs electronically and support development of web based tools to improve accessibility.Conclusions: Almost all pediatric residents, pediatric emergency physicians and general pediatricians sometimes refer to CPGs. General pediatricians teaching less than 6 weeks per year on CTUs are an important target population, as most use CPGs infrequently. Prompts that CPGs exist and accessible online summaries of CPGs appear to have potential for overcoming the barriers to use.
Quantitative evaluation of carbonation in concrete using nonlinear ultrasound
Authors: Kim Gun , Kim Jin-Yeon , Kurtis Kimberly E. , Jacobs Laurence J. , Le Pape Yann , Guimaraes Maria
Published: December 2014

A new nonlinear ultrasonic technique for nondestructive evaluation of concrete components is developed and implemented to characterize the effects of carbonation on concrete. The physical principle of this method is the second harmonic generation (SHG) in propagating Rayleigh surface waves which are detected by a non-contact air-coupled transducer. The nonlinearity parameter, as an indicator of material properties, is experimentally obtained from measured Rayleigh wave signals and is used to quantitatively evaluate the progress of carbonation under accelerated conditions. The experimental results show that there is a significant decrease in the measured nonlinearity parameter, most likely originated from the deposit of the carbonation product, CaCO3, in pre-existing voids and microcracks. The sensitivity of the nonlinearity parameter is also verified by comparing with the measured Rayleigh wave velocity. The results in this paper demonstrate that the SHG technique using Rayleigh surface waves can be used to monitor carbonation in concrete.
Development and application of an eDNA method to detect and quantify a pathogenic parasite in aquatic ecosystems
Authors: Huver J. R. , Koprivnikar J. , Johnson P. T. J. , Whyard S.
Published: December 2014

Approaches based on organismal DNA found in the environment (eDNA) have become increasingly utilized for ecological studies and biodiversity inventories as an alternative to traditional field survey methods. Such DNA‐based techniques have largely been used to establish the presence of free‐living organisms, but have much potential for detecting and quantifying infectious agents in the environment, which is necessary to evaluate disease risk. We developed an eDNA method to examine the distribution and abundance of the trematode Ribeiroia ondatrae, a pathogenic parasite known to cause malformations in North American amphibians. In addition to comparing this eDNA approach to classical host necropsy, we examined the detectability of R. ondatrae in water samples subject to different degradation conditions (time and temperature). Our test exhibited high specificity and sensitivity to R. ondatrae, capable of detecting as little as 14 fg (femtograms) of this parasite's DNA (1/2500th of a single infectious stage) from field water samples. Compared to our results from amphibian host necropsy, quantitative PCR was ~90% concordant with respect to R. ondatrae detection from 15 field sites and was also a significant predictor of host infection abundance. DNA was still detectable in lab samples after 21 days at 25°C, indicating that our method is robust to field conditions. By comparing the advantages and disadvantages of eDNA vs. traditional survey methods for determining pathogen presence and abundance in the field, we found that the lower cost and effort associated with eDNA approaches provide many advantages. The development of alternative tools is critical for disease ecology, as wildlife management and conservation efforts require reliable establishment and monitoring of pathogens.
Isolated Irreducible Chronic Volar Dislocation of the Distal Radioulnar Joint
Authors: Li Yuan , Yan Hui
Published: December 2014

Case:

We report a case of a fifty-eight-year-old woman who sustained a chronic dislocation of the distal radioulnar joint (DRUJ) with extensive secondary cartilage damage and bone loss. We performed an open reduction to restore normal alignment of the distal part of the radius and the distal part of the ulna while preserving the structures that provide stability to the DRUJ.

Conclusion:

At eighteen months postoperatively, the patient had regained 60° of pronation and 60° of supination and did not have any pain. We found that even in a chronic injury, a simple anatomic reduction can restore the stability of the DRUJ.
A Left Nonrecurrent Inferior Laryngeal Nerve in a Patient with Vascular and Atlantoaxial Abnormalities
Authors: Ladeira Craveiro Vinicius , Osler Polina , Rocco James W. , Schwab Joseph H.
Published: December 2014

Case:

We present a case of a fifty-eight-year-old woman with chronic occipital headaches and neck pain who underwent C2-C3 anterior and posterior fusion for cervical instability. Perioperative discovery of multiple cervical anomalies, including a left nonrecurrent inferior laryngeal nerve, greatly complicated the approach.

Conclusion:

A left nonrecurrent inferior laryngeal nerve is a rare anatomical anomaly that may co-occur with other cervical abnormalities. It is an important anatomical variant to consider during an anterior approach to the cervical spine, especially when preoperative images of the cervical region show vascular and cervical spine anatomical anomalies.
Fractal analysis in digital cartographic modeling of Miroc mountain
Authors: Valjarevic Aleksandar , Zivkovic Dragica , Petrasevic Aleksandra
Published: December 2014

Miroc is a mountain in Eastern Serbia placed between Donji Milanovac and
Tekija in Negotinska Krajina. The highest mountain summit is Veliki Strbac,
768 metres above sea level. Miroc is the most protruding part of Eastern
Serbia and the most western part of the Djerdap Mountain Massive. The
mountain is surrounded by the Danube from all the sides. Miroc Mountain,
Veliki and Mali Srbac, the Danube River, the Djerdap Gorge, Veliki and Mali
Kazan are the real place of world permeation both on land and in the water.
This embraces the territory of nearly 500 km2. Fractal Geometry is a sort of
new language used for describing, modeling or analyzing complex shapes in
nature. A fractal is a diminished unity copy; the type that resembles itself.
The work objective is to show the possibility of using computer analyses as
well as the programme languages Python, C++, GIS software, Global Mapper 15.2
and QGIS/a in the example of Miroc Mountain morphometric features.
On strategic spatial planning
Authors: Tosic Branka , Zivanovic Zora
Published: December 2014

The goal of this paper is to explain the origin and development of strategic
spatial planning, to show complex features and highlight the differences
and/or advantages over traditional, physical spatial planning. Strategic
spatial planning is seen as one of approaches in legally defined planning
documents, and throughout the display of properties of sectoral national
strategies, as well as issues of strategic planning at the local level in
Serbia. The strategic approach is clearly recognized at the national and
sub-national level of spatial planning in European countries and in our
country. It has been confirmed by the goals outlined in documents of the
European Union and Serbia that promote the grounds of territorial cohesion
and strategic integrated planning, emphasizing cooperation and the principles
of sustainable spatial development.
Plant waste materials from restaurants as the adsorbents for dyes
Authors: Pavlovic Marija , Nikolic Ivan , Milutinovic Milica , Dimitrijevic-Brankovic Suzana , Siler-Marinkovic Slavica , Antonovic Dusan
Published: December 2014

This paper has demonstrated the valorization of inexpensive and readily
available restaurant waste containing most consumed food and beverage
residues as adsorbents for methylene blue dye. Coffee, tea, lettuce and
citrus waste have been utilized without any pre-treatment, thus the
adsorption capacities and dye removal efficiency were determined. Coffee
waste showed highest adsorbent capacity, followed by tea, lettuce and citrus
waste. The dye removal was more effective as dye concentration increases from
5 up to 60 mg/L. The favorable results obtained for lettuce waste have been
especially encouraged, as this material has not been commonly employed for
sorption purposes. Equilibrium data fitted very well in a Freundlich isotherm
model, whereas pseudo-second-order kinetic model describes the process
behavior. Restaurant waste performed rapid dye removal at no cost, so it can
be adopted and widely used in industries for contaminated water treatment.
Slip effects on unsteady free convective heat and mass transfer flow with Newtonian heating
Authors: Hussanan Abid , Khan Ilyas , Salleh Mohd , Shafie Sharidan
Published: December 2014

This article investigates the effects of slip condition on free convection
flow of viscous incompressible fluid past an oscillating vertical plate with
Newtonian heating and constant mass diffusion. The governing equations
together with imposed initial and boundary conditions are solved using the
Laplace transform technique. The results for velocity, temperature and
concentration are obtained and plotted for the embedded parameters. The
results for skin friction, Nusselt number and Sherwood number are computed in
table. It is investigated that the presence of slip parameter reduces the
fluid velocity.
Determining the reliability function of the thermal power system in power plant "Nikola Tesla, Block B1"
Authors: Kalaba Dragan , Djordjevic Milan , Kirin Snezana
Published: December 2014

Representation of probabilistic technique for evaluation of thermal power
system reliability is the main subject of this paper. The system of thermal
power plant under study consists of three subsystems and the reliability
assessment is based on a sixteen-year failure database. By applying the
mathematical theory of reliability to exploitation research data and using
complex two-parameter Weibull distribution, the theoretical reliability
functions of specified system have been determined. Obtained probabilistic
laws of failure occurrence have confirmed a hypothesis that the distribution
of the observed random variable fully describes behaviour of such a system in
terms of reliability. Shown results make possible to acquire a better
knowledge of current state of the system, as well as a more accurate
estimation of its behavior during future exploitation. Final benefit is
opportunity for potential improvement of complex system maintenance policies
aimed at the reduction of unexpected failure occurrences.
Water-based squeezing flow in the presence of carbon nanotubes between two parallel disks
Authors: Haq Rizwan , Hammouch Zakia , Khan Waqar
Published: December 2014

Present study is dedicated to investigate the water functionalized carbon
nanotubes squeezing flow between two parallel discs. Moreover, we have
considered magnetohydrodynamics effects normal to the disks. In addition we
have considered two kind of carbon nanotubes named: single wall carbon
nanotubes (SWCNT) and multiple wall carbon nanotubes (MWCNT) with in the base
fluid. Under this squeezing flow mechanism model has been constructed in the
form of partial differential equation. Transformed ordinary differential
equations are solved numerically with the help of Runge-Kutta-Fehlberg
method. Results for velocity and temperature are constructed against all the
emerging parameters. Comparison among the SWCNT and MWCNT are drawn for skin
friction coefficient and local Nusselt number. Conclusion remarks are drawn
under the observation of whole analysis.