bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring and Management of the Palliative Care Patient Symptoms: A Best Practice Implementation Project
Authors: Coelho Adriana , Rocha Ana , Cardoso Daniela , Rodrigues Rogério , Costeira Cristina , Gomes Sara , Parola Vitor
Published: May 2022

Background: In palliative care, symptoms are multiple and combined, evolving and changing, with a multidimensional character and multifactorial causes, and a high prevalence, negatively influencing the patient’s and family’s quality of life. Nurses who provide palliative care need to recognize and respond effectively to their patients’ symptoms. Methods: A project will be applied to implement the best practice in monitoring and managing palliative care patients’ symptoms. The Joanna Briggs Institute Practical Application of Clinical Evidence System (JBI PACES) and Getting Research into Practice (GRiP) audit and feedback tool will be used. The JBI PACES and GRiP framework for promoting evidence-based healthcare involves three phases of activity. First, a baseline audit. In a second phase, feedback will be given to the project team after the conclusion of the baseline audit report. Then, a third phase will be conducted as a follow-up audit. Conclusions: This project will improve the practice of the nursing team in monitoring and managing the symptoms of palliative care patients, positively influencing the quality of life of the patient and his family. The implementation and dissemination of this project could boost its replication in other centres.
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate the Safety and Efficacy of ThymoQuinone Formula (TQF) for Treating Outpatient SARS-CoV-2
Authors: Bencheqroun Hassan , Ahmed Yasir , Kocak Mehmet , Villa Enrique , Barrera Cesar , Mohiuddin Mariya , Fortunet Raul , Iyoha Emmanuel , Bates Deborah , Okpalor Chinedu , Agbosasa Ola , Mohammed Karim , Pondell Stephen , Mohamed Amr , Mohamed Yehia I. , Gok Yavuz Betul , Kaseb Mohamed O. , Kasseb Osama O. , Gocio Michelle York , Tu Peter Tsu-Man , Li Dan , Lu Jianming , Selim Abdulhafez , Ma Qing , Kaseb Ahmed O.
Published: May 2022

There is an urgent need for an oral drug for the treatment of mild to moderate outpatient SARS-CoV-2. Our preclinical and clinical study’s aim was to determine the safety and preliminary efficacy of oral TQ Formula (TQF), in the treatment of outpatient SARS-CoV-2. In a double-blind, placebo-controlled phase 2 trial, we randomly assigned (1:1 ratio) non-hospitalized, adult (>18 years), symptomatic SARS-CoV-2 patients to receive oral TQF or placebo. The primary endpoints were safety and the median time-to-sustained-clinical-response (SCR). SCR was 6 days in the TQF arm vs. 8 days in the placebo arm (p = 0.77), and 5 days in the TQF arm vs. 7.5 days in the placebo arm in the high-risk cohort, HR 1.55 (95% CI: 0.70, 3.43, p = 0.25). No significant difference was found in the rate of AEs (p = 0.16). TQF led to a significantly faster decline in the total symptom burden (TSB) (p < 0.001), and a significant increase in cytotoxic CD8+ (p = 0.042) and helper CD4+ (p = 0.042) central memory T lymphocytes. TQF exhibited an in vitro inhibitory effect on the entry of five SARS-CoV-2 variants. TQF was well-tolerated. While the median time-to-SCR did not reach statistical significance; it was shorter in the TQF arm and preclinical/clinical signals of TQF activity across multiple endpoints were significant. Therefore, a confirmatory study is planned.
Phytoremediation of Heavy Metals: An Indispensable Contrivance in Green Remediation Technology
Authors: Sabreena  , Hassan Shahnawaz , Bhat Sartaj Ahmad , Kumar Vineet , Ganai Bashir Ahmad , Ameen Fuad
Published: May 2022

Environmental contamination is triggered by various anthropogenic activities, such as using pesticides, toxic chemicals, industrial effluents, and metals. Pollution not only affects both lotic and lentic environments but also terrestrial habitats, substantially endangering plants, animals, and human wellbeing. The traditional techniques used to eradicate the pollutants from soil and water are considered expensive, environmentally harmful and, typically, inefficacious. Thus, to abate the detrimental consequences of heavy metals, phytoremediation is one of the sustainable options for pollution remediation. The process involved is simple, effective, and economically efficient with large-scale extensive applicability. This green technology and its byproducts have several other essential utilities. Phytoremediation, in principle, utilizes solar energy and has an extraordinary perspective for abating and assembling heavy metals. The technique of phytoremediation has developed in contemporary times as an efficient method and its success depends on plant species selection. Here in this synthesis, we are presenting a scoping review of phytoremediation, its basic principles, techniques, and potential anticipated prospects. Furthermore, a detailed overview pertaining to biochemical aspects, progression of genetic engineering, and the exertion of macrophytes in phytoremediation has been provided. Such a promising technique is economically effective as well as eco-friendly, decontaminating and remediating the pollutants from the biosphere.
Selected Physico-Chemical, Nutritional, Antioxidant and Sensory Properties of Wheat Bread Supplemented with Apple Pomace Powder as a By-Product from Juice Production
Authors: Valková Veronika , Ďúranová Hana , Havrlentová Michaela , Ivanišová Eva , Mezey Ján , Tóthová Zuzana , Gabríny Lucia , Kačániová Miroslava
Published: May 2022

The present article aimed to study the effects of four selected concentrations (1%, 2%, 5%, and 10%) of apple pomace powder (APP), obtained from juice production, on the nutritional value and selected physico-chemical, antioxidant, and sensory properties of wheat bread. We have found that the ash and total carbohydrate contents, total polyphenols content, and antioxidant activity of the supplemented bread loaves were markedly higher (p < 0.05) as compared to the control ones. On the other hand, values for protein and fat contents and loaf volume in APP-containing bread samples were statistically lower (p < 0.05). Finally, sensory evaluation revealed no significant differences in all tested attributes between the investigated groups of bread samples. The current results suggest that 10% APP addition appears to be an attractive ingredient applied to bread formulation to obtain a bakery product with high nutritional value and required qualitative and sensory properties. In such a manner, apple pomace as by-products from apple juice processing can be efficiently utilized in an eco-friendly way by the food industry to decrease unnecessary waste and environmental pollution.
QTL and Candidate Genes for Seed Tocopherol Content in ‘Forrest’ by ‘Williams 82’ Recombinant Inbred Line (RIL) Population of Soybean
Authors: Knizia Dounya , Yuan Jiazheng , Lakhssassi Naoufal , El Baze Abdelhalim , Cullen Mallory , Vuong Tri , Mazouz Hamid , T. Nguyen Henry , Kassem My Abdelmajid , Meksem Khalid
Published: May 2022

Soybean seeds are rich in secondary metabolites which are beneficial for human health, including tocopherols. Tocopherols play an important role in human and animal nutrition thanks to their antioxidant activity. In this study, the ‘Forrest’ by ‘Williams 82’ (F×W82) recombinant inbred line (RIL) population (n = 306) was used to map quantitative trait loci (QTL) for seed α-tocopherol, β-tocopherol, δ -tocopherol, γ-tocopherol, and total tocopherol contents in Carbondale, IL over two years. Also, the identification of the candidate genes involved in soybean tocopherols biosynthetic pathway was performed. A total of 32 QTL controlling various seed tocopherol contents have been identified and mapped on Chrs. 1, 2, 5, 6, 7, 8, 9, 10, 12, 13, 16, 17, and 20. One major and novel QTL was identified on Chr. 6 with an R2 of 27.8, 9.9, and 6.9 for δ-tocopherol, α-tocopherol, and total tocopherol content, respectively. Reverse BLAST analysis of the genes that were identified in Arabidopsis allowed the identification of 37 genes involved in soybean tocopherol pathway, among which 11 were located close to the identified QTLs. The tocopherol cyclase gene (TC) Glyma.06G084100 is located close to the QTLs controlling δ-tocopherol (R2 = 27.8), α-tocopherol (R2 = 9.96), and total-tocopherol (R2 = 6.95). The geranylgeranyl diphosphate reductase (GGDR) Glyma.05G026200 gene is located close to a QTL controlling total tocopherol content in soybean (R2 = 4.42). The two methylphytylbenzoquinol methyltransferase (MPBQ-MT) candidate genes Glyma.02G002000 and Glyma.02G143700 are located close to a QTL controlling δ-tocopherol content (R2 = 3.57). The two γ-tocopherol methyltransferase (γ-TMT) genes, Glyma.12G014200 and Glyma.12G014300, are located close to QTLs controlling (γ+ß) tocopherol content (R2 = 8.86) and total tocopherol (R2 = 5.94). The identified tocopherol seed QTLs and candidate genes will be beneficial in breeding programs to develop soybean cultivars with high tocopherol contents.
Nutrients Uptake and Accumulation in Plant Parts of Fragrant Rosa Species Irrigated with Treated and Untreated Wastewater
Authors: Ahsan Muhammad , Nafees Muhammad , Amin Muhammad , Nawaz Fahim , Tufail Aasma , Sardar Hasan , Shokralla Shadi , Mahmoud Eman A. , El-Sabrout Ahmed M. , Elansary Hosam O.
Published: May 2022

Water scarcity has critically augmented the need for the exploration of alternative irrigation sources mainly in water-scarce regions. This water scarcity has put tremendous pressure on the agri-based economy of countries such as Pakistan. The reuse of sewage wastewater has been appearing as the only alternative water source, which can lessen our dependence upon freshwater (FW). The current study aimed to scrutinize the influence of treated wastewater (TWW) and untreated wastewater (UTWW) irrigation on the nutrient (N, P, K, Ca, and Na) concentration in different plant parts, i.e., roots, stems, leaves, and flowers, of four scented Rosa species (R. bourboniana, R. centifolia, R. Gruss-an-telpitz, and R. damascena) during the first week of 2018 to the last week of 2019. The experiment was arranged according to the two-factor factorial arrangement i.e., factor I was the irrigation source, while factor II was the Rosa species. The experimental water analysis showed that mineral and chemical concentrations in FW and TWW were within permissible limits of national environmental quality standards (NEQSs) for wastewater. The UTWW of this study possessed a higher electrical conductivity (EC), chemical oxygen demand (COD), biological oxygen demand (BOD), total nitrogen (TN), and metals (Cd, Co, and Pb) than recommended levels. The results revealed that P, K, Ca, and Na contents significantly increased in all studied plant parts of Rosa species as the duration of irrigation with TWW and UTWW increased and vice versa in the case of N contents, while the ratio of N content elevation by applying TWW and UTWW were also not increased compared to other studied nutrients. The nutrients (except Ca) were found as maximum in all plant parts with UTWW compared to FW and TWW irrigation in roses. These stimulations were accredited to the presence of higher essential nutrients and some metals in UTWW. This experiment confirmed the disparities in nutrient contents of scented Rosa species due to the different absorbability of each element in every plant part. Regarding the nutrient accumulation in rose plant tissues, the results of the present study confirm that untreated wastewater must be treated to some extent to grow scented roses where water is scarce.
Changes in Carbon and Nitrogen Metabolites before, at, and after Anthesis for Wheat Cultivars in Response to Reduced Soil Water and Zinc Foliar Application
Authors: Mahdy Rasha E. , Alghamdi Sameera A. , Amro Ahmed , Tammam Suzan A.
Published: May 2022

Water deficit stress is one of the major constraints for commercial agriculture, as it disturbs the metabolic processes in plant. Identification of carbon and nitrogen receptors that act on drought resistance helps in breeding for drought resistance varieties. Zn fertilizer can regulate multiple antioxidant defense systems at the transcriptional level in response to drought. Two field experiments were conducted in 2018–2019 and 2019–2020 seasons to explore the effectiveness of foliar application of zinc oxide on soluble sugar, soluble proteins, and free amino acids under normal irrigation and drought-stressed environments. Three Egyptian wheat cultivars (Triticum aestivum L.) were used. The experimental design was split-plot in RCBD with three replications, applying zinc oxide levels to the whole plot and the split plots. Leaf samples were taken for analysis before anthesis, at anthesis, and after anthesis. Application of Zn increased soluble sugars. However, the free amino acids were higher under irrigation, reached the maximum at anthesis, and decreased sharply after 2 weeks from anthesis. The ranking of cultivars for the three metabolites differed according to plant stage, reflecting the response to Zn and years. Correlations between metabolites according to Zn were positive. The findings suggest the potential of foliar application of Zn to alleviate drought stress.
Phytochemicals and Nano-Phytopharmaceuticals Use in Skin, Urogenital and Locomotor Disorders: Are We There?
Authors: Rajagopal Mogana , Paul Alok K. , Lee Ming-Tatt , Joykin Anabelle Rose , Por Choo-Shiuan , Mahboob Tooba , Salibay Cristina C. , Torres Mario S. , Guiang Maria Melanie M. , Rahmatullah Mohammed , Jahan Rownak , Jannat Khoshnur , Wilairatana Polrat , de Lourdes Pereira Maria , Lim Chooi Ling , Nissapatorn Veeranoot
Published: May 2022

Nanomedicines emerged from nanotechnology and have been introduced to bring advancements in treating multiple diseases. Nano-phytomedicines are synthesized from active phytoconstituents or plant extracts. Advancements in nanotechnology also help in the diagnosis, monitoring, control, and prevention of various diseases. The field of nanomedicine and the improvements of nanoparticles has been of keen interest in multiple industries, including pharmaceutics, diagnostics, electronics, communications, and cosmetics. In herbal medicines, these nanoparticles have several attractive properties that have brought them to the forefront in searching for novel drug delivery systems by enhancing efficacy, bioavailability, and target specificity. The current review investigated various therapeutic applications of different nano-phytopharmaceuticals in locomotor, dermal, reproductive, and urinary tract disorders to enhance bioavailability and efficacy of phytochemicals and herbal extracts in preclinical and in vitro studies. There is a lack of clinical and extensive preclinical studies. The research in this field is expanding but strong evidence on the efficacy of these nano-phytopharmaceuticals for human use is still limited. The long-term efficacy and safety of nano-phytopharmaceuticals must be ensured with priority before these materials emerge as common human therapeutics. Overall, this review provides up-to-date information on related contemporary research on nano-phytopharmaceuticals and nano-extracts in the fields of dermatological, urogenital, and locomotor disorders.
A Trans-Disciplinary and Integral Model of Participatory Planning for a More Sustainable and Resilient Basilicata
Authors: Loperte Simona
Published: May 2022

This article focuses on the importance of a trans-disciplinary and participatory planning approach aiming at promoting a more resilient community. The COVID-19 outbreak is not just a health pandemic, but also a compound crisis in a globalized world, which emphasizes the need for, and urgency of, an ecological transition towards a new development model. This paper presents the outcomes of a research experience aimed at implementing a new development model inspired by integral sustainability for a transformative resilience of Basilicata region (Southern Italy). The research approach was implemented according to a participatory planning methodology to overcome the significant impacts of the pandemic and guide the transition towards real, sustainable development in all its dimensions (economic, social, environmental, and institutional). Community engagement in a research partnership allowed stakeholders to benefit from collective wisdom, creating more meaningful findings in preparing the regional community to face the challenges of the ecological transition. Scientific support of the research was fundamental in supporting political decision making in identifying strategic actions for a more sustainable and resilient Basilicata in this delicate historical moment of awareness, where the future will depend on today’s choices.
Effect of Braiding Architectures on the Mechanical and Failure Behavior of 3D Braided Composites: Experimental Investigation
Authors: Zhang Di , Zheng Xitao , Zhou Jin , Song Xinyi , Jia Pu , Liu Haibao , Liu Xiaochuan
Published: May 2022

Benefiting from the multi-directional load-bearing capability, the three-dimensional braided composites (3DBC) have found a wide application in primary structures. It is therefore of great importance to fully understand their mechanical behavior and failure modes. In the present paper, the tensile and compressive tests were carried out, according to standardized testing methods, for eight types of 3DBC, which were manufactured by resin transfer molding (RTM). It was found that the mechanical properties of the 3DBCs decreased with an increasing braiding angle. When the braiding angle was 20°, 3D 5-directional braided composite (3D5dBC) exhibited the best mechanical properties, while for the braiding angle of 40°, the mechanical properties of 3D6dBC were the most prominent. Moreover, the tensile strength of the 3DBCs is approximately two times as much as the compressive strength; however, the compressive modulus is always 10% higher than the tensile modulus. The failure modes of the 3DBCs with a braiding angle of 20°greatly depended on the braiding structures. However, they tend to be consistent when the braiding angle increases to 40°.
A Study on the Dynamic Effects and Ecological Stress of Eco-Environment in the Headwaters of the Yangtze River Based on Improved DeepLab V3+ Network
Authors: Wang Chunsheng , Zhang Rui , Chang Lili
Published: May 2022

The headwaters of the Yangtze River are a complicated system composed of different eco-environment elements. The abnormal moisture and energy exchanges between the atmosphere and earth systems caused by global climate change are predicted to produce drastic changes in these eco-environment elements. In order to study the dynamic effect and ecological stress in the eco-environment, we adapted the Double Attention Mechanism (DAM) to improve the performance of the DeepLab V3+ network in large-scale semantic segmentation. We proposed Elements Fragmentation (EF) and Elements Information Content (EIC) to quantitatively analyze the spatial distribution characteristics and spatial relationships of eco-environment elements. In this paper, the following conclusions were drawn: (1) we established sample sets based on “Sentinel-2” remote sensing images using the interpretation signs of eco-environment elements; (2) the mAP, mIoU, and Kappa of the improved DeepLab V3+ method were 0.639, 0.778, and 0.825, respectively, which demonstrates a good ability to distinguish the eco-environment elements; (3) between 2015 and 2021, EF gradually increased from 0.2234 to 0.2394, and EIC increased from 23.80 to 25.32, which shows that the eco-environment is oriented to complex, heterogeneous, and discontinuous processes; (4) the headwaters of the Yangtze River are a community of life, and thus we should build a multifunctional ecological management system with which to implement well-organized and efficient scientific ecological rehabilitation projects.
Pedestrian Detection Using Integrated Aggregate Channel Features and Multitask Cascaded Convolutional Neural-Network-Based Face Detectors
Authors: Yuan Jing , Barmpoutis Panagiotis , Stathaki Tania
Published: May 2022

Pedestrian detection is a challenging task, mainly owing to the numerous appearances of human bodies. Modern detectors extract representative features via the deep neural network; however, they usually require a large training set and high-performance GPUs. For these cases, we propose a novel human detection approach that integrates a pretrained face detector based on multitask cascaded convolutional neural networks and a traditional pedestrian detector based on aggregate channel features via a score combination module. The proposed detector is a promising approach that can be used to handle pedestrian detection with limited datasets and computational resources. The proposed detector is investigated comprehensively in terms of parameter choices to optimize its performance. The robustness of the proposed detector in terms of the training set, test set, and threshold is observed via tests and cross dataset validations on various pedestrian datasets, including the INRIA, part of the ETHZ, and the Caltech and Citypersons datasets. Experiments have proved that this integrated detector yields a significant increase in recall and a decrease in the log average miss rate compared with sole use of the traditional pedestrian detector. At the same time, the proposed method achieves a comparable performance to FRCNN on the INRIA test set compared with sole use of the Aggregated Channel Features detector.
Intestinal Glucuronidation, Prior to Hepatic Glucuronidation, Plays an Important Role in the Low Circulating Levels of Calycosin
Authors: Jiang Haodong , Liu Huan , Hu Pei , Chen Shuoji , Ye Yaqing , Huang Chenggang , Tian Xiaoting
Published: May 2022

Calycosin is a dietary flavonoid with favorable activities, which seems to be inconsistent with its low circulating levels in vivo. To address this issue, we developed a strategy to understand calycosin distribution by integrating qualitative and quantitative analyses of calycosin and its metabolites in portal vein plasma, the liver, and systemic plasma after oral administration to rats. Consequently, 21 metabolites were characterized in total, including the first report of a reductive biotransformation and 14 new metabolites. Compared with the low levels of calycosin, calycosin glucuronides were predominant in circulation, and both the hepatic and intestinal regions contributed to the high exposure of these calycosin glucuronides. However, intestinal glucuronidation, prior to hepatic glucuronidation, plays a key role in the low circulating levels of calycosin.
“Mix of Races, Bad Uterus”: Obstetric Violence in the Experiences of Afro-Brazilian Migrants in Portugal
Authors: Barata Catarina
Published: May 2022

In this article, I address the issues of obstetric violence and racism in the Portuguese setting of obstetric care. Based on data collected through interviews and participatory artistic creation, I analyze the perception of three Afro-Brazilian migrants about their perinatal experiences of obstetric care in the Portuguese public sector between 2013 and 2019. These women’s experiences have much in common with experiences of obstetric violence as narrated by Portuguese, non-racialized women. Despite this, certain aspects of their experience are related to their particular identification as Brazilian, migrant, and Black, such as xenophobic discrimination and their placement in systems of stratified reproduction, including a supposed tendency for birth by caesarean section, as well as self-policing behaviors because of the stereotype of Brazilian women as flirty. I consider a range of manifestations of obstetric violence and racism, from more overt forms to more covert ones, to analyze how, in a country where racism and obstetric violence are only slowly beginning to be recognized as the norm, multiple discriminations intersect and have an impact on the experiences of women of their bodies in pregnancy, birth, and postpartum, including breastfeeding.
Standards and Assessment of Construction Products: Case Study of Ceramic Tile Adhesives
Authors: Michalak Jacek
Published: May 2022

This work attempts to draw attention to the importance of a multidimensional approach when creating standard requirements in the assessment of construction products with the example of ceramic tile adhesives (CTAs). CTAs are an essential group of building materials today, the continuous development of which has been noted since the 1960s. However, until 2001, i.e., the year when EN 12004 was published, there were no precise requirements for CTAs at the European level, which often made it difficult or, in extreme cases, even impossible to assess the product objectively. Under the provisions of EN 12004, for twenty years, the basis for the assessment and verification of constancy of performance (AVCP) of CTAs has been adhesion determined by tensile strength. The paper discusses the test methods, paying attention to their imperfections, including the impact of the materials used in measurements, i.e., concrete slab, ceramic tile, and water quality. The results of the multi-annual interlaboratory tests indicate that an essential factor that must be considered in the process of AVCP is test measurement uncertainty. Additionally, it should be remembered that uncertainty also occurs at other assessment levels. It also seems that the simple acceptance rule that does not consider the variability resulting from the measurement uncertainty is inadequate when assessing CTAs.
Dengue and COVID-19: Managing Undifferentiated Febrile Illness during a “Twindemic”
Authors: Wee Liang En , Conceicao Edwin Philip , Sim Jean Xiang-Ying , Aung May Kyawt , Oo Aung Myat , Yong Yang , Arora Shalvi , Venkatachalam Indumathi
Published: May 2022

Background: During the COVID-19 pandemic, distinguishing dengue from COVID-19 in endemic areas can be difficult, as both may present as undifferentiated febrile illness. COVID-19 cases may also present with false-positive dengue serology. Hospitalisation protocols for managing undifferentiated febrile illness are essential in mitigating the risk from both COVID-19 and dengue. Methods: At a tertiary hospital contending with COVID-19 during a dengue epidemic, a triage strategy of routine COVID-19 testing for febrile patients with viral prodromes was used. All febrile patients with viral prodromes and no epidemiologic risk for COVID-19 were first admitted to a designated ward for COVID-19 testing, from January 2020 to December 2021. Results: A total of 6103 cases of COVID-19 and 1251 cases of dengue were managed at our institution, comprising a total of 3.9% (6103/155,452) and 0.8% (1251/155,452) of admissions, respectively. A surge in dengue hospitalisations in mid-2020 corresponded closely with the imposition of a community-wide lockdown. A total of 23 cases of PCR-proven COVID-19 infection with positive dengue serology were identified, of whom only two were true co-infections; both had been appropriately isolated upon admission. Average length-of-stay for dengue cases initially admitted to isolation during the pandemic was 8.35 days (S.D. = 6.53), compared with 6.91 days (S.D. = 8.61) for cases admitted outside isolation (1.44 days, 95%CI = 0.58–2.30, p = 0.001). Pre-pandemic, only 1.6% (9/580) of dengue cases were admitted initially to isolation-areas; in contrast, during the pandemic period, 66.6% (833/1251) of dengue cases were initially admitted to isolation-areas while awaiting the results of SARS-CoV-2 testing. Conclusions: During successive COVID-19 pandemic waves in a dengue-endemic country, coinfection with dengue and COVID-19 was uncommon. Routine COVID-19 testing for febrile patients with viral prodromes mitigated the potential infection-prevention risk from COVID-19 cases, albeit with an increased length-of-stay for dengue hospitalizations admitted initially to isolation.
Book Review: The Annotated Passover Haggadah Edited by Zev Garber and Kenneth Hanson
Authors: Burza Mehak
Published: May 2022

The Annotated Passover Haggadah, coedited by Professors Zev Garber and Kenneth Hanson, is a meticulous collaboration that incorporates a set of essays by various authors. The book offers unique reflections from myriad vantage points to the well known and often repeated story of the Jewish ritual. The essence of The Annotated Passover Hagaddah lies not only in the central theme of celebration of the Haggadah but also in the numerous ways in which it can be celebrated in other traditions, as well as how it has evolved through times. It is this renewed prospect that imparts multiple connotations to the Jewish Passover ritual. The book has an eclectic prominence that manifests through a careful hermeneutical exploration of the Passover Haggadah from the Judeo-Christian prism. With significant overlaps between the Christian and Jewish liturgy, this culturally rich interfaith volume transcends the scope of the Jewish ritual of Passover and Haggadah.
Hybrid FiST_CNN approach for Feature Extraction for Vision-Based Indian Sign Language Recognition
Authors: Tyagi Akansha , Bansal Sandhya
Published: May 2022

Indian sign language (ISL) is the commonly used language by the deaf-mute community in the Indian continent. Effective feature extraction is essential for the automatic recognition of gestures. This paper aims at developing an efficient feature extraction technique using FAST, SIFT, and CNN. Features from Fast Accelerated Segment Test(FAST) with Scale-invariant Feature Transformation(SIFT) are used to detect and compute features, respectively. CNN is used for classification with the hybridization of FAST-SIFT features. The system is implemented and tested using the python-based library Keras. The results of the proposed techniques have been tested on 34 gestures of ISL (24 alphabet sets and 10 digit sets) and then compared with the CNN and SIFT_CNN, and it is also tested on two publicly available datasets on Jochen Trisech Dataset(JTD) and NUS-II dataset. The proposed study outperformed some existing ISLR works with an accuracy of 97.89%, 95.68%, 94.90% and 95.87% for ISL-alphabets, MNIST, JTD and NUS-II, respectively.
Ultrasensitive Frequency Shifting of Dielectric Mie Resonance near Metallic Substrate
Authors: Liu Chuanbao , Wang Changxin , Chen Junhong , Su Yanjing , Qiao Lijie , Zhou Ji , Bai Yang
Published: May 2022

Dielectric resonators on metallic surface can enhance far-field scattering and boost near-field response having promising applications in nonlinear optics and reflection-type devices. However, the dependence of gap size between dielectric resonator and metallic surface on Mie resonant frequency is complex and desires a comprehensive physical interpretation. Here, we systematically study the effect of metallic substrate on the magnetic dipole (MD) resonant frequency at X-band by placing a high permittivity CaTiO
3
ceramic block on metallic substrate and regulating their gap size. The simulated and experimental results show that there are two physical mechanisms to codetermine the metallic substrate-induced MD frequency. The greatly enhanced electric field pair in the gap and the coupling of MD resonance with its mirror image are decisive for small and large gaps, respectively, making the MD resonant frequency present an exponential blue shift first and then a slight red shift with increasing gap size. Further, we use the two mechanisms to explain different frequency shifting properties of ceramic sphere near metallic substrate. Finally, taking advantage of the sharp frequency shifting to small gaps, the ceramic block is demonstrated to accurately estimate the thickness or permittivity of thin film on metallic substrate through a governing equation derived from the method of symbolic regression. We believe that our study will help to understand the resonant frequency shifting for dielectric particle near metallic substrate and give some prototypes of ultrasensitive detectors.
Hemolytic uremic syndrome following COVID-19; a case report
Authors: Emami Elham , Safari Samaneh , Javanmard Pedram
Published: May 2022

High incidence of thromboembolic diseases in patients with coronavirus disease 2019 (COVID-19) have been reported that can affect several organs ranging from cutaneous thrombosis to pulmonary embolism, stroke, coronary thrombosis or kidney infarction. There are two proposed mechanisms for these phenomena, disseminated intravascular coagulation (DIC) and endotheliopathy. We report a case of 11-year-old girl presented to the emergency department with generalized tonic colonic seizure with upward gaze which was repeated in emergency room. Respiratory distress and loss of consciousness happened which led to her intubation. Due to increased serum creatinine levels and impaired consciousness which was associated with thrombocytopenia and hemolysis, she underwent plasmapheresis three times by the diagnosis of hemolytic uremic syndrome. Additionally, antihypertensive therapy was conducted. The patient’s condition improved and was discharged with good circumstances. Two weeks later the patient returned with thromboembolism that happened in the distal part of her left hand which underwent fasciotomy and thrombectomy.
Reference Interval of Muscle Damage Indices and Cortisol in Young Athletes of Various Sports Discipline
Authors: Sarkar Surojit , Dey Swapan Kumar , Datta Gouriprosad , Bandyopadhyay Amit
Published: May 2022

Creatine kinase (CK), lactate dehydrogenase (LDH) and cortisol are widely accepted as biological markers. The purpose of the study was to frame the reference interval for muscle damage indices (CK, LDH) and cortisol in the young athletic population of various sports disciplines. 260 young male players [i.e., football (n=62), hockey (n=60), gymnastics (n=36), swimming (n=28), table tennis (n=25), sprint-jump-throw (n=36) and middle-long distance running (n=13)] were recruited for the study (mean age = 15.6±1.59 yrs). Assay of LDH, CK and cortisol was done using the standard enzymatic protocol. The reference interval was calculated by following the Clinical and Laboratory Standard Institute (CLSI) C28-A3 guideline and “MedCalc” software (version 19) with a 90% confidence interval. Serum LDH range was from 148.00-324.00 IU/L with a mean of 233.2±34.74 and a median around 236.25. Serum CK ranged from 17.00-43.50 IU/L with a mean of 28.93±5.23 IU/L and a median around 28.00. Cortisol ranged from 4.99-15.78 µg/dl with a mean of 9.31±2.09 µg/dl and a median around 8.90. The present study confers 165.63 - 303.43 IU/L, 19.00 – 40.09 IU/L and 6.07-14.15 µg/dl as the reference interval values for LDH, CK and cortisol, respectively. The present finding will guide the researchers to avoid misinterpretation of muscle damage indices values during any phase of competitive training of sports person.
TAXONOMIC REMARKS ON SIDEROLITES JURASSICA YOUSSEF & EL-SOROGY, 2015, CALLOVIAN OF SAUDI-ARABIA
Authors: SCHLAGINTWEIT FELIX
Published: May 2022

The increasing availability of numerous journals with limited peer review and editorial standards has led to an ever-increasing introduction of new fossil taxa that ultimately need taxonomic revision. The introduction of dubious and poorly described taxa adds confusion to the scientific literature. Furthermore, their potential inclusion in global taxonomic databases, and the subsequent usage of this data in review papers necessitates critical comment and thoughtful clarification. The recent introduction of Siderolites jurassica Youssef & El-Sorogy is a good example of a taxon that is both poorly described and which clouds the literature, thus requiring revision. This species was described and illustrated from just one isolated specimen obtained from Callovian marls in Saudi Arabia. Siderolites represents an exclusively Upper Cretaceous (Campanian-Maastrichtian) complex rotaloid Large Benthic Foraminifera with a distinctive identity that can be clearly deciphered by studying oriented and random thin-sections. A Jurassic occurrence would overturn our current understanding of foraminiferal evolution as well as their usage for biostrat-igraphic analyses. It is suspected that the Middle Jurassic specimen described from Saudi Arabia belongs to a small-sized group of arenaceous benthic foraminifera exhibiting conical protuberances (or spines) such as Thurammina Brady and should neither be regarded as belonging to the genus Siderolites nor any other siderolitid representative.
Comparison of the physical properties of woven and warp knitted bathrobe
towel fabrics produced with similar properties
Authors: MUHAMMET AKAYDIN
Published: May 2022

In recent years, the use of towel fabrics produced by warp knitting machines in the production of bathrobe fabrics has
gradually increased. These fabrics, which can be produced more massively at a lower cost, also show a more flexible
character than woven towel fabrics. When working with two pile yarn groups whose raw materials or properties are
different from each other, the creation of fabric structures with a completely different face and back is seen among the
reasons for choosing these fabrics. In this study, after determining the basic performance characteristics such as weight,
tensile strength, tear strength, bursting resistance, shrinkage, and water absorbency of the bathrobe towel fabrics
produced with the weaving and warp knitting technique, which has undergone the same finishing processes, their
performance and strength properties were compared with each other and the results were evaluated using statistical
analysis methods. It has been determined that while woven towel fabrics give higher strength values, warp-knitted towel
fabrics show higher stretch. The degree of hydrophilicity degree is increased significantly after sequential finishing
processes in both towel fabrics. As a result of the finishing processes, there was a general decrease in the tear strength
of the woven bathrobe terry fabric, while there was no systematic decrease in the other strength parameters and the
strength properties of the warp-knitted towel fabric. In consequence of the finishing processes in both towel fabric
structures, a significant reduction in size was observed in the warp direction.
Últimos avances en el tratamiento neoadyuvante de cáncer de vejiga
Authors: Valencia Guillermo , Rioja Patricia , Morante Zaida , Paz Roberto , Vallejos Heberth , Fuentes Hugo , Neciosup Silvia
Published: May 2022

La quimioterapia neoadyuvante basada en cisplatino ha demostrado un claro beneficio encáncer de vejiga músculo invasivo (MIBC) EC II o IIIA, logrando un impacto en la sobrevidalibre de progresión y sobrevida global. Esta revisión actualizada se centra en el tratamientoneoadyuvante del MIBC, incluyendo las recomendaciones actuales de las guías de práctica clínicainternacionales y/o locales, así como el estudio de nuevos agentes terapéuticos (inmunoterapia,terapias dirigidas) además de la investigación de potenciales biomarcadores predictivos derespuesta a inmunoterapia.
Factores de riesgo asociados a hipoglucemia en recién nacidos
Authors: Ynguil Amaya Willam , Caciano Leiva Berardo , Vega Díaz Hugo , Avilés Bravo
Published: May 2022

Se realizó un artículo de revisión narrativo para evaluar los factores de riesgo relacionados con la hipoglucemia en los recién nacidos. Los objetivos buscaron determinar la evidencia clínica de los factores de riesgo relacionados con la hipoglucemia neonatal y determinar el soporte fisiopatológico sobre los factores de riesgo implicados en el desarrollo de hipoglucemia en los recién nacidos. Se han realizado búsquedas literarias en Medline-Pubmed, SCOPUS e HINARI sobre artículos publicados hasta noviembre de 2021; Esto arrojó un total de 108 artículos. Se concluye que, aunque el cribado universal de hipoglucemia en recién nacidos asintomáticos y de bajo riesgo puede ser innecesario, existe evidencia de que la hipoglucemia puede causar anomalías en el desarrollo neurológico; siendo factores de riesgo maternos de hipoglucemia en neonatos tales como: diabetes gestacional, preeclampsia y obesidad gestacional; Los factores de riesgodel recién nacido para hipoglucemia neonatal son: sepsis, bajo peso al nacer y prematuridad.
Predictores de mortalidad intrahospitalaria y de mal pronóstico funcional en pacientes sometidos a evacuación quirúrgica de hemorragia intracerebral
Authors: Saal-Zapata Giancarlo , Vargas-Urbina John , Reyes-Narro Gianfranco , Rodríguez-Calienes Aarón , Rodríguez-Varela Rodolfo
Published: May 2022

Objetivo: Determinar predictores de mortalidad intrahospitalaria y mal pronóstico funcional en pacientes sometidos a cirugía por hemorragia intracerebral.

Materiales y métodos: Se analizaron las historias clínicas, reportes operatorios y tomografías cerebrales de pacientes con hemorragia intracerebral desde marzo 2018 hasta marzo de 2020. Se realizó un análisis de regresión logística univariado y multivariado para determinar predictores independientes de mortalidad intrahospitalaria y mal pronóstico funcional al alta.

Resultados: La mortalidad intrahospitalaria fue de 33.7% (n = 31 pacientes). Predictores independientes de mortalidad fueron el sexo femenino (OR = 3.01; p = 0.031) y un Glasgow < 8 puntos al ingreso (OR = 3.19; p = 0.031). Un mal pronóstico funcional luego de la intervención se encontró en 77 pacientes (83.7%). Predictores independientes de mal pronóstico funcional fueron una Escala de Rankin modificada > 3 (OR = 15.5; p = 0.01) y déficit motor pre-operatorio (OR = 8.95; p = 0.042).

Conclusiones: En pacientes con diagnóstico de hemorragia intracerebral tratados con cirugía se encontró una alta mortalidad y morbilidad. El sexo femenino y factores clínicos como el estado de conciencia y el estado funcional al ingreso fueron predictores independientes de mortalidad intrahospitalaria y mal pronóstico funcional.
Discectomía transtorácica extrapleural sin fusión para resección de hernia del disco dorsal calcificada gigante: Reporte de caso y revisión de literatura
Authors: Murga Villanueva Annel , Basurco-Carpio Alfonso , Laos-Plasier Eduardo
Published: May 2022

Introducción: Las hernias del disco torácico calcificadas son poco frecuentes y su abordaje representa u n desafío quirúrgico cuando son gigantes y sintomáticas. La discectomía transtorácica extrapleural puede considerarse un abordaje seguro para resecar el fragmento de disco calcificado y descomprimir la médula espinal. Caso clínico: Hombre de 53 años con dorsalgia media irradiada a región inframamaria y dificultad progresiva para deambular, paraparesia proximal moderada, nivel sensitivo T8 y retención urinaria. Las imágenes demostraron una gran hernia de disco T6-7 calcificada que causaba una compresión severa de la médula espinal. El paciente se sometió a discectomía transtorácica extrapleural T6-7 más corpectomía parcial T6 sin fusión. El paciente toleró bien el procedimiento sin complicaciones y las imágenes postoperatorias al mes de la cirugia demostraron la descompresión de la médula espinal. En el seguimiento, la dorsalgia irradiada, el nivel sensitivo, la paraparesia y la retención urinaria mejoraron.
Karakteristik Mutu Bakso Ikan Tuna dengan Penambahan Tepung Agar-Agar
Authors: Samudra Muhammad Jihad , Taher Nurmeilita , Onibala Hens , Reo Albert , Mewengkang Hanny , Mentang Feny
Published: May 2022

The quality of fish balls is one of the indicators used in the food industry, this study aims toanalyze the best quality of tuna fish balls with the addition of gelatin flour by increasing theanalysis of water content, ash content, crude fiber content and organoleptic. The method that will be used in this research is descriptive exploratory with 4, namely the addition of agar-agar flour (T0), the addition of 6g of gelatin flour (T1), the addition of 8g of agar-agar flour (T2) and the addition of 10g of agar-agar flour (T3 ). The results of data analysis showed that the addition of agar-agar flour was able to improve the quality of tuna fish balls, the addition of 10g agar-agarflour was the best treatment with a round and neat shape of meatballs with a distinctive smell oftuna and jelly with a strong gel texture and does not break when folded, water content is 72.57%,ash content is 0.62%, crude fiber is 29.61%.
ASSESSMENT OF THE STABILITY OF LANDSLIDE-PRONE SLOPES UNDER THE INFLUENCE OF UNDERMINED AREAS OF THE CITY OF KOK-JANGAK (USING THE BY COMPUTER PROGRAM PLAXIS)
Authors: Abdirashitova N.A. , Fedorenko E.V.
Published: May 2022

The article presents the results of numerical modeling using the PLAXIS program to assess the stability of landslide-prone slopes under the influence of undermined areas of the city of Kok-Jangak. Recent studies have shown that the stability of mountain slopes and slopes depends on landslides, degradation processes, hydrogeological regimes, geological conditions, and landslide hazard conditions.
DEVELOPMENT OF MOBILE APPLICATION FOR SALARY CALCULATION
Authors: Sharsheeva K. T. , Zhumabaeva A.N. , Tagaeva Sh. A.
Published: May 2022

This article analyzes existing mobile applications for calculation of wages; also we considered main stages of creation mobile applications. Calculation method for determining of the amount of wages in Kyrgyz Republic has been determined. Android operating system, Java programming language and Android Studio integrated development environment are briefly considered in it. Start box for entering applications has been developed and input activities’ process and employee data output determine salary are shown.
PROSPECTS FOR THE DEVELOPMENT OF SMALL-SCALE ENERGY IN KYRGYZSTAN BASED ON RENEWABLE AND ALTERNATIVE ENERGY SOURCES
Authors: Asanov A.A. , Dzhamankyzov N.K. , Niyazov N.T. , Mekenbaev B.T. , Turdakun uulu Nurgazy
Published: May 2022

The article discusses the current state of production electricity in the republic. The possibilities of building objects are shown small energy, based on renewable and alternative resources energy sources. The substantiation of the expediency of network development is given small HPPs, taking into account the hydrogeological characteristics of slightly inclined flat rivers313 and canals. The main tasks to be solved during the construction of energy facilities on such watercourses are formulated. Showing advantages of new types of installations for generating electricity according to compared with traditional types on flat rivers and canals.
POSSIBILITY OF TEACHING LEVELS IN COURSES OF MATHEMATICS WITH USE OF INFORMATION TECHNOLOGIES
Authors: Japarova S.N. , Mukanbetova S.A. , Alybekova P.A.
Published: May 2022

Currently, the main goal of general education is to be intellectually and physically developed, have a wide range of spiritual needs, have a scientific worldview, be ready to take an active part in the life of society, be able to act independently and evaluate events, adapt to changes in society. This is the formation of personality. The article developed exercises for creating equations and transmitting them to students using the LearningApps.org application. The course of mathematics shows the organization of online learning using information technology. The teacher creates an algorithm for the equations in the application, solves linear equations and shares exercises with students to restore them. The app assesses student performance and allows students to use the assessment results and provide feedback.
THEORY AND PRACTICE OF TRANSLATION AS A BASIS FOR THE STUDY OF COMPUTER TERMINOLOGY
Authors: Jumalieva G. E.
Published: May 2022

In this article we considered theory of translation as a main theory of our comparative translation English-Kyrgyz research and tendency in development of theory and practice of translation related to both English and Kyrgyz languages in linguistic space of Kyrgyzstan. In our article, we consider a set of basic issues of theory and practice of translation and clarified them. The study of following five fundamental issues of the theory and practice of translation prompted us to find out two principles of translation equivalence, as “formal-grammatical principle” and “dynamic-culturological principle” into five types of equivalence, corresponding to five levels hierarchically located equivalence of translation, and highlighted by Russian Soviet translation scholars and their Kyrgyz researchers.