bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling of the spatial distribution of Pacific spiny dogfish (Squalus suckleyi) in the Gulf of Alaska using generalized additive and generalized linear models
Authors: Gasper Jason R. , Kruse Gordon H.
Published: June 2013

The Pacific spiny dogfish (Squalus suckleyi) is a common bycatch species in the Gulf of Alaska. Their spatial distribution is poorly understood, as most catch is discarded at sea. We analyzed spiny dogfish spatial distribution from fishery-dependent and -independent observations of longline gear between 1996 and 2008 using generalized additive and generalized linear models. Poisson, negative binomial, and quasi-Poisson error structures were investigated; the quasi-Poisson generalized additive model fit best. Models showed that spiny dogfish catches were concentrated east of Kodiak Island in waters ≤100 m deep. Results facilitate design of future spiny dogfish assessment surveys and identification of areas in which to focus at-sea observations for fishing mortality estimation, and provide the basis for first-ever designation of spiny dogfish essential fish habitat, despite US legal requirements for essential fish habitat designations since 1996. Identified areas of high bycatch may expedite spatial management by indicating areas in which directed spiny dogfish fisheries could be focused or, conversely, areas in which heightened conservation and catch accounting efforts would be most effective to prevent overfishing of this long-lived, late-maturing species.
ANTI-PERIODIC TYPE BOUNDARY VALUE PROBLEMS FOR SINGULAR MULTI-TERM FRACTIONAL DIFFERENTIAL EQUATIONS WITH IMPULSE EFFECTS
Authors: LIU YUJI
Published: June 2013

Results on the existence of solutions of anti-periodic type boundary value problems for singular multi-term fractional differential equations with impulse effects are established. We first transform the problem into a hybrid system, then construct a weighted Banach space and a completely continuous operator, and finally, we use the fixed point theorem in the Banach space to prove the main results. An example is given to illustrate the efficiency of the main theorems.
INFORMED REACTIVE TABU SEARCH FOR GRAPH COLORING
Authors: PORUMBEL DANIEL COSMIN , HAO JIN-KAO , KUNTZ PASCALE
Published: June 2013

Tabu search (TS) has always been a very popular algorithm for graph coloring, both as a stand-alone optimizer as well as a subroutine inside population-based hybrid methods. We present two TS extensions that could allow previous TS algorithms to improve their behavior at almost no additional computational cost. First, we integrate two new evaluation functions which employ supplementary (structural or dynamic) information in addition to the conventional objective function (the number of edges with both ends of the same color). These new evaluation functions allow the search process to differentiate configurations not distinguished by the conventional evaluation function. The second extension concerns a reactive mechanism for improving the tabu list management. Theoretical arguments show that this reactive component completely eliminates the risk of getting blocked looping on plateaus. Numerical experiments show that the two proposed TS extensions can be very useful inside a stand-alone TS optimizer, as well as inside TS subroutines of state-of-the-art hybrid methods.
LUNAR SYSTEM CONSTRAINTS ON THE MODIFIED THEORIES OF GRAVITY
Authors: EXIRIFARD QASEM
Published: June 2013

The Modified Newtonian Dynamics (MOND) paradigm to the missing mass problem requires introducing a functional that is to be identified through observations and experiments. We consider the aquadratic Lagrangian theory as a realization of the MOND. We show that the accurate value of the Earth GM measured by the lunar laser ranging measurements and that by various artificial Earth satellites, including the accurate tracking of the LAGEOS satellites, constrain this functional such that some of the chosen/proposed functional are refuted.
CREDIT DERIVATIVES PRICING WITH STOCHASTIC VOLATILITY MODELS
Authors: CHIARELLA CARL , MAINA SAMUEL CHEGE , SKLIBOSIOS CHRISTINA NIKITOPOULOS
Published: June 2013

This paper proposes a model for pricing credit derivatives in a defaultable HJM framework. The model features hump-shaped, level dependent, and unspanned stochastic volatility, and accommodates a correlation structure between the stochastic volatility, the default-free interest rates, and the credit spreads. The model is finite-dimensional, and leads (a) to exponentially affine default-free and defaultable bond prices, and (b) to an approximation for pricing credit default swaps and swaptions in terms of defaultable bond prices with varying maturities. A numerical study demonstrates that the model captures stylized various features of credit default swaps and swaptions.
Effects of sleeve gastrectomy and ileal transposition, alone and in combination, on food intake, body weight, gut hormones, and glucose metabolism in rats
Authors: Nausheen S. , Shah I. H. , Pezeshki A. , Sigalet D. L. , Chelikani P. K.
Published: June 2013

Bariatric surgeries are hypothesized to produce weight loss and improve diabetes control by multiple mechanisms including gastric restriction and lower gut stimulation; the relative importance of these mechanisms remains poorly understood. We compared the effects of a typical foregut procedure, sleeve gastrectomy, (SG) with a primarily hindgut surgery, ileal transposition (IT), alone and together (SGIT), or sham manipulations, on food intake, body weight, gut hormones, glucose tolerance, and key markers of glucose homeostasis in peripheral tissues of adult male Sprague-Dawley rats (450–550 g, n = 7–9/group). SG, IT, and SGIT surgeries produced transient reduction in food intake and weight gain; the effects of SG and IT on intake and body weight were nonadditive. SG, IT, and SGIT surgeries resulted in increased tissue expression and plasma concentrations of the lower gut hormones glucagon-like peptide-1 and peptide YY and decreased plasma glucose-dependent insulinotropic peptide, insulin, and leptin concentrations. Despite transient effects on intake and weight gain, the SG, IT, and SGIT surgeries produced a significant improvement in glucose tolerance. In support of glycemic improvements, the protein abundance of key markers of glucose metabolism (e.g., GLUT4, PKA, IRS-1) in muscle and adipose tissue were increased, whereas the expression of key gluconeogenic enzyme in liver (G-6-Pase) were decreased following the surgeries. Therefore, our data suggest that enhanced lower gut stimulation following SG, IT, and SGIT surgeries leads to transient reduction in food intake and weight gain together with enhanced secretion of lower gut hormones and improved glucose clearance by peripheral tissues.
Relationship between Conformation Traits and Lifetime Production Efficiency of Cows
Authors: Sawa A. , Bogucki M. , Krężel-Czopek S. , Neja W.
Published: June 2013

Analysis was made of the relationship between conformation traits and lifetime production efficiency of the cows that first calved in 2000 and represented the active population in the Pomorze and Kujawy regions of Poland. The CORR Pearson procedures of SAS package were used in the statistical calculations. It was found that there is a statistically significant relationship, weak or low on the Guilford scale, between conformation traits and lifetime production efficiency of the cows, which is slightly higher for milk yield than for longevity. The type and conformation traits appear to be more suitable than the detailed traits for predicting the lifetime production efficiency of cows. Lifetime performance was most strongly related to the overall score and udder score (r=0.22), followed by the scores for type and conformation and legs and feet (r=0.13), and detailed traits such as udder width and dairy character (r=0.14). The highest positive effect on longevity was exerted by udder score and legs and feet (r=0.11) and among detailed traits by udder placement (r=0.14) and fore udder attachment (r=0.10).
Wearable Quarter-Wave Folded Microstrip Antenna for Passive UHF RFID Applications
Authors: Kaufmann Thomas , Ranasinghe Damith C. , Zhou Ming , Fumeaux Christophe
Published: June 2013

A wearable low-profile inset-fed quarter-wave folded microstrip patch antenna for noninvasive activity monitoring of elderly is presented. The proposed antenna is embedded with a sensor-enabled passive radio-frequency identification (RFID) tag operating in the ultra-high frequency (UHF) industrial-scientific-medical (ISM) band around 900 MHz. The device exhibits a low and narrow profile based on a planar folded quarter-wave length patch structure and is integrated on a flexible substrate to maximise comfort to the wearer. An extended ground plane made from silver fabric successfully minimises the impact of the human body on the antenna performance. Measurements on a prototype demonstrate a reflection coefficient (S11) of −30 dB at resonance and a −10 dB bandwidth from 920 MHz to 926 MHz. Simulation results predict a maximum gain of 2.8 dBi. This is confirmed by tag measurements where a 4-meter read range is achieved using a transmit power of 30 dBm, for the case where the passive wearable tag antenna is mounted on a body in a practical setting. This represents an almost 40% increase in read range over an existing dipole antenna placed over a 10 mm isolator layer on a human subject.
Classification of Pulmonary Nodules by Using Hybrid Features
Authors: Tartar Ahmet , Kilic Niyazi , Akan Aydin
Published: June 2013

Early detection of pulmonary nodules is extremely important for the diagnosis and treatment of lung cancer. In this study, a new classification approach for pulmonary nodules from CT imagery is presented by using hybrid features. Four different methods are introduced for the proposed system. The overall detection performance is evaluated using various classifiers. The results are compared to similar techniques in the literature by using standard measures. The proposed approach with the hybrid features results in 90.7% classification accuracy (89.6% sensitivity and 87.5% specificity).
Study on the Dynamic Compound Structure Composed of Mast Cells, Blood Vessels, and Nerves in Rat Acupoint
Authors: Mingfu Luo , Xiaotong Dong , Xiaojing Song , Jin Jiang , Jinling Zhann , Ying Han
Published: June 2013

Background. Circulation system, immunity system, and nervous system have a close relationship with meridian phenomen. However, there is still lack of the results of dynamic changes of these structures in acupoint. The aim of this study is to explore the interrelationship by composite staining techniques.Methodology/Principal Findings. Twenty rats were separated into electroacupuncture group (EA) and control group (Con) randomly. In EA group, the Zusanli and Weishu were stimulated with the 0.1 mA for 25 min. The tissue of these acupoints was double-stained with acetylcholinesterase and Toluidine blue. The compound structure of mast cells, nervous fibers, and mast cells in the acupoint was observed.Conclusions/Significance. The blood vessels, mast cells and acetylcholinesterase responded nerves were clearly observed in acupoint tissues. EA can result in the mast cell recruitment and migration along the blood vessels and nervous bundle, which conformed the dynamic compound structure and played important roles in acupuncture.
B-Flow Twinkling Sign in Preoperative Evaluation of Cervical Lymph Nodes in Patients with Papillary Thyroid Carcinoma
Authors: Napolitano Giuseppina , Romeo Antonio , Bianco Andrea , Gasperi Maurizio , Zeppa Pio , Brunese Luca
Published: June 2013

Papillary thyroid cancer (PTC) is the most common histologic type of differentiated thyroid cancer. The first site of metastasis is the cervical lymph nodes (LNs). The ultrasonography (US) is the best diagnostic method for the detection of cervical metastatic LNs. We use a new technique, B-flow imaging (BFI), recently used for evaluation of thyroid nodules, to estimate the presence of BFI twinkling signs (BFI-TS), within metastatic LNs in patients with PTC. Two hundred and fifty-two patients with known PTC were examined for preoperative evaluation with conventional US and BFI. Only 83 with at least one metastatic LN were included. All patients included underwent surgery; the final diagnosis was based on the results of histology. The following LN characteristics were evaluated: shape, abnormal echogenicity, absent hilum, calcifications, cystic appearance, peripheral vascularization, and BFI-TS. A total of 604 LNs were analyzed. Of these, 298 were metastatic, according to histopathology. The BFI-TS showed high values​​of specificity (99.7%) and sensitivity (80.9%). The combination of each conventional US sign with the BF-TS increases the specificity. Our findings suggest that BFI can be helpful in the selection of suspicious neck LNs that should be examined at cytologic examination for accurate preoperative staging and individual therapy selection.
Echocardiography in the Era of Multimodality Cardiovascular Imaging
Authors: Shah Benoy Nalin
Published: June 2013

Echocardiography remains the most frequently performed cardiac imaging investigation and is an invaluable tool for detailed and accurate evaluation of cardiac structure and function. Echocardiography, nuclear cardiology, cardiac magnetic resonance imaging, and cardiovascular-computed tomography comprise the subspeciality of cardiovascular imaging, and these techniques are often used together for a multimodality, comprehensive assessment of a number of cardiac diseases. This paper provides the general cardiologist and physician with an overview of state-of-the-art modern echocardiography, summarising established indications as well as highlighting advances in stress echocardiography, three-dimensional echocardiography, deformation imaging, and contrast echocardiography. Strengths and limitations of echocardiography are discussed as well as the growing role of real-time three-dimensional echocardiography in the guidance of structural heart interventions in the cardiac catheter laboratory.
Temporal Patterns of Energy Balance for a Brazilian Tropical Savanna under Contrasting Seasonal Conditions
Authors: Rodrigues Thiago R. , de Paulo Sérgio R. , Novais Jonathan W. Z. , Curado Leone F. A. , Nogueira José S. , de Oliveira Renan G. , Lobo Francisco de A. , Vourlitis George L.
Published: June 2013

The savanna of Central Brazil (locally known as cerrado) has a long history of land cover change due to human activity. These changes have led to the degradation of cerrado forests and woodlands, leading to the expansion of grass-dominated cerrados and pastures. Thus, the aim of this study was to evaluate the temporal variation in energy flux in areas of degraded, grass-dominated cerrado (locally known as campo sujo) in Central Brazil. The amount of Rn partitioned into H declined as monthly rainfall increased and reached a level of approximately 30% during the wet season, while the amount of Rn partitioned into Le increased as monthly rainfall increased and reached a level of approximately 60% during the wet season. As a result, H was significantly higher than Le during the dry season, resulting in a Bowen ratio (β = H/Le) of 3-5, while Le was higher than H during the wet season, resulting in a β≈1. These data indicate that the energy partitioning of grass-dominated cerrado is relatively more sensitive to water availability than cerrado woodlands and forests, and have important implications for local and regional energy balance.
Enhancing Seismic Capacity of Pile-Supported Wharves Using Yielding Dampers
Authors: Mousavi Seyed Amin , Bargi Khosrow
Published: June 2013

This paper presents a numerical study on the seismic response of pile-supported wharves equipped with metallic yielding dampers. Using 20 ground acceleration records, the contribution of the yielding damper is examined, and its main parameters are optimized through a parametric study. In the current study, considering coupling effects of different parameters, a new optimization procedure is proposed. The obtained results indicate that the stability condition of the retaining wall (quay wall) behind the wharf, period of the soil-wharf system, and also maximum allowable ductility ratio of the damper are the key factors affecting the optimum damper parameters. A simplified design guideline is proposed for either the design or the retrofit purposes followed by a numerical assessment to evaluate the contribution of the proposed damper on the seismic behavior of a typical pile-supported wharf. The obtained results show that yielding dampers, through their nonlinear behavior, can dissipate a large portion of seismic input energy and mitigate piles damages which have been observed in earlier earthquake events.
Set Contractions and KKM Mappings in Banach Spaces
Authors: Razani A. , Karamikabir N.
Published: June 2013

Some fixed point theorems for generalized set contraction maps and KKM type ones in Banach spaces are presented. Moreover, a new generalized set contraction is introduced. As an application, some coincidence theorems for KKM type set contractions are obtained.
Assessment of Gingival Health Status among 5- and 12-Year-Old Children in Yemen: A Cross-Sectional Study
Authors: Al-Haddad Khaled A. , Ibrahim Yahia T. , Al-Haddad Ahmed M. , Al-Hebshi Nezar N.
Published: June 2013

Purpose. There are limited data about the gingival health status in Yemeni children. The aim, therefore, was to assess oral hygiene status and prevalence and severity of gingivitis among Yemeni preschool and school children. Materials and Methods. A total of 5396 children were included from 5 representative Yemeni governorates: Sana'a, Hajjah, Hodeida, Hadramaut, and Taiz. Five-year olds (1292) were recruited from private kindergartens while 12-year olds (4104) were selected from public primary schools. Gingival health status was assessed using the plaque index (PI), calculus index (CAI), and gingival index (GI) on the 6 Ramfjord teeth. The latter index was used to categorize gingivitis severity at the subject level. Data were analyzed using simple hypothesis testing, as well as ordinal regression. Results. The 12-year old children had significantly much higher mean PI, CAI, and GI (P<0.001) with 78.6% presenting with gingivitis and 47.8% with moderate gingivitis. In contrast, the figures were 27.2% and 3.1% in the younger group (P<0.001). There were significant variations according to gender, area of residence, and governorate. Regression analysis revealed that mean PI (OR=35), mean CAI (OR=7.7), male gender (OR=1.6), living in rural areas (OR=1.4), and being from Hajjah or Sana’a were independent risk factors of gingivitis severity in the older group. For the 5-year olds, the determinants were mean PI (OR=122), male gender (OR=1.4), and living in Sana'a or Taiz. Conclusions. Bad oral hygiene and moderate gingivitis are highly prevalent among Yemeni preschool and school children. Geographical location appeared as important independent risk factors of gingival inflammation.
Identification of Asbestos Using Laser-Induced Breakdown Spectroscopy: A Viable Alternative to the Conventional Approach?
Authors: Benton David M.
Published: June 2013

Laser-induced breakdown spectroscopy has been performed on isolated samples of six types of asbestos—Chrysotile, Crocidolite, Amosite, Anthophyllite, Actinolite, and Tremolite—with analysis of optical emission in the visible region of the spectrum. The principal elements of Mg, Fe, Si, Na, and Ca have all been identified. By examining peak intensity ratios of these elements it is possible to identify the type of asbestos under examination solely from internal examination of the sample spectra. LIBS offers some significant advantages of speed of analysis and removal of subjectivity with potential for on-site rapid analysis.
Timosaponin AIII Suppresses Hepatocyte Growth Factor-Induced Invasive Activity through Sustained ERK Activation in Breast Cancer MDA-MB-231 Cells
Authors: Tsai Chung-Hsin , Yang Chu-Wen , Wang Jir-You , Tsai Yi-Fang , Tseng Ling-Ming , King Kuan-Liang , Chen Wei-Shone , Chiu Jen-Hwey , Shyr Yi-Ming
Published: June 2013

Background. The aim of this study was to investigate the mechanisms by which Timosaponin AIII (TAIII) is able to inhibit HGF-induced invasion activity in the triple negative breast cancer cell line MDA-MB-231.Methods. After pretreatment with different concentrations (10−6~10−8 M) of TAIII, the cells were treated with hepatocyte growth factor (HGF, 15 ng/mL). At different time intervals after coincubation, various parameters, including the expression of c-Met, ERK, COX2, and MMP-9, which were assessed by Western blotting or by real-time PCR, were analyzed. In addition, invasive activity was also monitored.Results. HGF was found to induce c-MET activation and ERK activation, together with increased COX2 protein expression; these changes were followed by a subsequent increase in invasive activity. TAIII was found to suppress HGF-induced invasive activity andCOX2gene expression in a concentration-dependent manner (10−6~10−8 M) in parallel with increases in the phosphoforms of c-Met and ERK after TAIII treatment. The mechanisms by which TAIII suppresses HGF-induced invasive activity were demonstrated to include sustained cytoplasmic and nuclear ERK activation; these led to a suppression of nuclear ATF2 activation, which was followed by downregulation ofCOX2andMMP-9transcription.Conclusion. TAIII suppresses HGF-induced invasive activity in MDA-MB-231 cells via sustained ERK activation.
Stability and Bifurcation Analysis for a Predator-Prey Model with Discrete and Distributed Delay
Authors: Shi Ruiqing , Qi Junmei , Tang Sanyi
Published: June 2013

We propose a two-dimensional predatory-prey model with discrete and distributed delay. By the use of a new variable, the original two-dimensional system transforms into an equivalent three-dimensional system. Firstly, we study the existence and local stability of equilibria of the new system. And, by choosing the time delayτas a bifurcation parameter, we show that Hopf bifurcation can occur as the time delayτpasses through some critical values. Secondly, by the use of normal form theory and central manifold argument, we establish the direction and stability of Hopf bifurcation. At last, an example with numerical simulations is provided to verify the theoretical results. In addition, some simple discussion is also presented.
Effect of Land Use and Climate Change on Runoff in the Dongjiang Basin of South China
Authors: He Yanhu , Lin Kairong , Chen Xiaohong
Published: June 2013

Variability and availability of water resources under changing environment in a regional scale have been hot topics in recent years, due to the vulnerability of water resources associated with social and economic development. In this paper, four subbasins in the Dongjiang basin with a significant land use change were selected as case study. Runoffs of the four subbasins were simulated using the SCS monthly model to identify the quantitative impacts of land use and climate change. The results showed that (1), in the Dongjiang basin, temperature increased significantly, evaporation and sunlight decreased strongly, while precipitation showed a nonsignificant increase; (2) since the 1980s, land uses in the Dongjiang basin have experienced a significant change with a prominent increase in urban areas, a moderate increase in farmlands, and a great decrease in forest areas; (3) the SCS monthly model performed well in the four subbasins giving that the more significant land use change in each subbasin, the more runoff change correspondingly; (4) overall, runoff change was contributed half and half by climate change and human activities, respectively, in all the subbasins, in which about 20%~30% change was contributed by land use change.
Mild Diabetes Models and Their Maternal-Fetal Repercussions
Authors: Damasceno D. C. , Sinzato Y. K. , Bueno A. , Netto A. O. , Dallaqua B. , Gallego F. Q. , Iessi I. L. , Corvino S. B. , Serrano R. G. , Marini G. , Piculo F. , Calderon I. M. P. , Rudge M. V. C.
Published: June 2013

The presence of diabetes in pregnancy leads to hormonal and metabolic changes making inappropriate intrauterine environment, favoring the onset of maternal and fetal complications. Human studies that explore mechanisms responsible for changes caused by diabetes are limited not only for ethical reasons but also by the many uncontrollable variables. Thus, there is a need to develop appropriate experimental models. The diabetes induced in laboratory animals can be performed by different methods depending on dose, route of administration, and the strain and age of animal used. Many of these studies are carried out in neonatal period or during pregnancy, but the results presented are controversial. So this paper, addresses the review about the different models of mild diabetes induction using streptozotocin in pregnant rats and their repercussions on the maternal and fetal organisms to propose an adequate model for each approached issue.
An Unusual Cause of Small Bowel Obstruction in a Child: Ingested Rhubarb
Authors: Glatstein Miguel , Danino Dana , Rimon Ayelet , Keidar Sergei , Scolnik Dennis
Published: June 2013

Small bowel obstruction is rarely caused by bezoars concretions formed from undigested foreign material in the gastrointestinal tract. An important cause of bezoars is phytobezoars, formed from vegetables or fruits. A four-year-old boy presented to our emergency department with symptoms of acute intestinal obstruction. Upright plain abdominal radiography revealed multiple air fluid levels. Ultrasound showed no abnormalities, and because of worsening symptoms computed tomography of abdomen was performed. It showed intraluminal obstruction of the terminal ileum. Exploratory laparotomy revealed a phytobezoar consisting of undigested rhubarb. The mass was milked through the large bowel and out the anus. Although rare in humans, bezoars are a well-documented cause of small bowel obstruction and should be considered when intraluminal bowel obstruction occurs. Bezoars causing small bowel obstruction may require surgical treatment.
Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases
Authors: Chi Hsiang Cheng , Chen Cheng-Yi , Tsai Ming-Ming , Tsai Chung-Ying , Lin Kwang-Huei
Published: June 2013

Thyroid hormones (THs) are potent mediators of several physiological processes, including embryonic development, cellular differentiation, metabolism, and cell growth. Triiodothyronine (T3) is the most biologically active TH form. Thyroid hormone receptors (TRs) belong to the nuclear receptor superfamily and mediate the biological functions of T3via transcriptional regulation. TRs generally form heterodimers with the retinoid X receptor (RXR) and regulate target genes upon T3stimulation. Research over the past few decades has revealed that disruption of cellular TH signaling triggers chronic liver diseases, including alcoholic or nonalcoholic fatty liver disease and hepatocellular carcinoma (HCC). Animal model experiments and epidemiologic studies to date imply close associations between high TH levels and prevention of liver disease. Moreover, several investigations spanning four decades have reported the therapeutic potential of T3analogs in lowering lipids, preventing chronic liver disease, and as anticancer agents. Thus, elucidating downstream genes/signaling pathways and molecular mechanisms of TH actions is critical for the treatment of significant public health issues. Here, we have reviewed recent studies focusing on the roles of THs and TRs in several disorders, in particular, liver diseases. We also discuss the potential therapeutic applications of THs and underlying molecular mechanisms.
Quantitative Global Estimates for Generalized Double Szasz-Mirakjan Operators
Authors: Ali Özarslan Mehmet , Aktuğlu Hüseyin
Published: June 2013

We introduce the generalized double Szász-Mirakjan operators in this paper. We obtain several quantitative estimates for these operators. These estimates help us to determine some function classes (including some Lipschitz-type spaces) which provide uniform convergence on the whole domain .
Regulation of DDAH1 as a Potential Therapeutic Target for Treating Cardiovascular Diseases
Authors: Liu Xiaoyu , Fassett John , Wei Yidong , Chen Yingjie
Published: June 2013

Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor that blocks nitric oxide production, while congestive heart failure is associated with increased plasma and tissue ADMA content. Increased plasma ADMA is a strong and independent predictor of all-cause mortality in the community and the strongest predictor of mortality in patients after myocardial infarction. Recent studies demonstrated that dimethylarginine dimethylaminohydrolase-1 (DDAH1) is the critical enzyme for ADMA degradation and thereby plays an important role in maintaining cardiovascular nitric oxide bioavailability. Interestingly, activation of the farnesoid X receptor (FXR) through the bile acid ursodeoxycholic acid (UDCA) or synthetic FXR agonists, such as GW4064, can increase DDAH1 expression. Thus, modulating DDAH1 activity through FXR receptor agonists such as UDCA could be a therapeutic target for treating reduced nitric oxide bioavailability in congestive heart failure and other cardiovascular diseases.
Antitussive Activity of the Water-Extracted Carbohydrate Polymer fromTerminalia chebulaon Citric Acid-Induced Cough
Authors: Nosalova Gabriela , Jurecek Ludovit , Chatterjee Udipta Ranjan , Majee Sujay Kumar , Nosal Slavomir , Ray Bimalendu
Published: June 2013

Terminalia chebula, a medicinal plant, is widely used in the management of various diseases. As the water extract of its dried ripe fruit is a frequently used preparation, we decided to look for bioactive polysaccharide in this extract. We demonstrate that the obtained polysaccharide fraction, CP, contained a highly branched arabinogalactan protein having a1→3-,1→6- and1→3,6-linkedβ-D-Galptogether with1→5- and1→3-linkedα-L-Arafand nonreducing end units ofα-L-Araf. This polymer possesses strong antitussive property. Our results showed that the number of citric acid-induced cough efforts decreased significantly after the oral application of polysaccharide fraction in a dose of 50 mg kg−1body weight. Its antitussive efficacy was higher than cough suppressive effect of standard drug codeine. Therefore, traditional aqueous extraction method provides a major polysaccharide, which induces a pharmacological effect: this could represent an attractive approach in phytotherapeutic managements.
Testing of the Structure and Mechanical Properties of Technical Titanium Joints
Authors: Wronka Bogumił
Published: June 2013

The aim of the research was the titanium pipeline welding technology. The transformations of this material due to the influence of thermal welding were analysed. The basic purpose was to evaluate the properties of titanium joint areas. Pipe joints of various thicknesses were welded by means of TIG argon arc welding while applying the optimum and reduced gas flow intensities. The structure and mechanical properties of these joints were tested. Different test results were obtained for joints welded in these two conditions. Recommendations concerning the welding technology and the heat treatment of joints after welding were presented.
Estimate of Number of Periodic Solutions of Second-Order Asymptotically Linear Difference System
Authors: Bin Honghua , Huang Zhenkun
Published: June 2013

We investigate the number of periodic solutions of second-order asymptotically linear difference system. The main tools are Morse theory and twist number, and the discussion in this paper is divided into three cases. As the system is resonant at infinity, we use perturbation method to study the compactness condition of functional. We obtain some new results concerning the lower bounds of the nonconstant periodic solutions for discrete system.
Multi Objective Optimization of Coordinated Scheduling of Cranes and Vehicles at Container Terminals
Authors: Homayouni Seyed Mahdi , Tang Sai Hong
Published: June 2013

According to previous researches, automated guided vehicles and quay cranes in container terminals have a high potential synergy. In this paper, a mixed integer programming model is formulated to optimize the coordinated scheduling of cranes and vehicles in container terminals. Objectives of the model are to minimize total traveling time of the vehicles and delays in tasks of cranes. A genetic algorithm is developed to solve the problem in reasonable computational time. The most appropriate control parameters for the proposed genetic algorithm are investigated in a medium size numerical test case. It is shown that balanced crossover and mutation rates have the best performance in finding a near optimal solution for the problem. Then, ten small size test cases are solved to evaluate the performance of the proposed optimization methods. The results show the applicability of the genetic algorithm since it can find near optimal solutions, precisely and accurately.
Simulators of Squamous Cell Carcinoma of the Skin: Diagnostic Challenges on Small Biopsies and Clinicopathological Correlation
Authors: Tan Kong-Bing , Tan Sze-Hwa , Aw Derrick Chen-Wee , Jaffar Huma , Lim Thiam-Chye , Lee Shu-Jin , Lee Yoke-Sun
Published: June 2013

Squamous cell carcinoma (SCC) is a common and important primary cutaneous malignancy. On skin biopsies, SCC is characterized by significant squamous cell atypia, abnormal keratinization, and invasive features. Diagnostic challenges may occasionally arise, especially in the setting of small punch biopsies or superficial shave biopsies, where only part of the lesion may be assessable by the pathologist. Benign mimics of SCC include pseudoepitheliomatous hyperplasia, eccrine squamous syringometaplasia, inverted follicular keratosis, and keratoacanthoma, while malignant mimics of SCC include basal cell carcinoma, melanoma, and metastatic carcinoma. The careful application of time-honored diagnostic criteria, close clinicopathological correlation and a selective request for a further, deeper, or wider biopsy remain the most useful strategies to clinch the correct diagnosis. This review aims to present the key differential diagnoses of SCC, to discuss common diagnostic pitfalls, and to recommend ways to deal with diagnostically challenging cases.
Vibrations due to Flow-Driven Repeated Impacts
Authors: Jeong Sumin , Baddour Natalie
Published: June 2013

We consider a two-degree-of-freedom model where the focus is on analyzing the vibrations of a fixed but flexible structure that is struck repeatedly by a second object. The repetitive impacts due to the second mass are driven by a flowing fluid. Morison’s equation is used to model the effect of the fluid on the properties of the structure. The model is developed based on both linearized and quadratic fluid drag forces, both of which are analyzed analytically and simulated numerically. Conservation of linear momentum and the coefficient of restitution are used to characterize the nature of the impacts between the two masses. A resonance condition of the model is analyzed with a Fourier transform. This model is proposed to explain the nature of ice-induced vibrations, without the need for a model of the ice-failure mechanism. The predictions of the model are compared to ice-induced vibrations data that are available in the open literature and found to be in good agreement. Therefore, the use of a repetitive impact model that does not require modeling the ice-failure mechanism can be used to explain some of the observed behavior of ice-induced vibrations.
Inflammatory Markers: C-Reactive Protein, Erythrocyte Sedimentation Rate, and Leukocyte Count in Vitamin D Deficient Patients with and without Chronic Kidney Disease
Authors: Yildirim Ibrahim , Hur Ender , Kokturk Furuzan
Published: June 2013

Although some studies revealed a positive relationship between vitamin D3deficiency and inflammatory markers, there have been also many studies that failed to find this relationship. The aim of this large scaled study is to determine the association between the level of plasma 25 hydroxy vitamin D3[25-(OH) D3] and inflammatory markers in the general population without chronic kidney disease (CKD) and in patients with CKD. Participants with simultaneously measured inflammatory markers and 25-(OH) D3levels were retrospectively analyzed (n=1897). The incidence of all-cause inflammation infection, hospitalization, chronic renal failure, and vitamin B12 deficiency was evaluated. The medians of serum creatinine levels in subjects without renal failure were lower in 25-(OH) D3deficient group. Patients with CKD were more likely to have vitamin D3deficiency compared with normal GFR. 25-(OH) D3levels were associated with a greater incidence of all-cause hospitalization, hypoalbuminemia, and vitamin B12 deficiency. However, there was no relationship between inflammatory markers and vitamin D3levels. In 25-(OH) D3deficient patients, inflammatory markers can be related to other inflammatory and infectious status such as malnutrition and cachexia. We believed that there must be a relationship between vitamin deficiency and inflammatory markers due to other causes than low 25-(OH) D3status.
Composite Energy Storage System with Photovoltaic Power Generation and Uninterruptible Power Supply Function
Authors: Kwon Jung-Min
Published: June 2013

A composite energy storage system (CESS) that includes a photovoltaic (PV) power generation and an uninterruptible power supply (UPS) function is proposed. This system has three operating modes, namely, a grid-connected inverter mode, a grid-connected rectifier mode, and an islanding mode. This system is composed of a boost converter, a three-phase inverter/rectifier, a bidirectional DC/DC converter, and thyristor switches. The boost converter extracts maximum power from the PV panels and sends it to the DC-link. The bidirectional DC/DC converter is connected between the battery and the DC-link, which leads to an optimized charging/discharging operation. The three-phase inverter/rectifier transmits the power to and from the grid. Also, it operates as a UPS in the islanding mode. The thyristor switches are used for connecting/disconnecting between the grid and the AC load. A 15 kW prototype is implemented to verify the performance of the proposed system.
Changes in Regulating Ecosystem Services following Establishing Exclosures on Communal Grazing Lands in Ethiopia: A Synthesis
Authors: Mekuria Wolde
Published: June 2013

In four separate studies undertaken in the northern highlands of Ethiopia, changes in regulating ecosystem services, economic viability, and the perception of local communities following establishing exclosures on communal grazing lands were investigated. Replicated 5-, 10-, 15-, and 20-year-old exclosures were selected and paired each exclosure with an adjacent grazing land. All exclosures displayed higher ecosystem services than communal grazing lands. Differences between exclosures and grazing lands varied between 29 (±4.9) and 61 (±6.7) Mg C ha−1 for ecosystem carbon stock (ECS), 2.4 (±0.6) and 6.9 (±1.8) Mg ha−1 for total soil N stock, and 17 (±3) to 39 (±7) Kg ha−1 for the available P stock, and all differences increased with exclosure duration. Differences in plant species richness and biomass between an exclosure age and communal grazing land were higher in oldest than in youngest exclosures. Over a period of 30 years, sequestered carbon dioxide was 246 Mg ha−1, total soil nitrogen increased by 7.9 Mg ha−1, and additional available phosphorous stocks amounted to 40 kg ha−1. The Net Present Value of exclosures ecosystem services under consideration was about 28% (837 US$) higher than alternative wheat production indicating that exclosures are competitive to alternative land uses. There are substantial opportunities to mobilize the local communities in efforts to establish exclosures, given that more than 75% had a positive view on exclosures effectiveness to restore degraded ecosystems. Establishing exclosures on communal grazing lands can be effective for restoring degraded ecosystems and the services that they provide.
Activation of TRPV1 Prevents OxLDL-Induced Lipid Accumulation and TNF-α-Induced Inflammation in Macrophages: Role of Liver X Receptorα
Authors: Zhao Jin-Feng , Ching Li-Chieh , Kou Yu Ru , Lin Shing-Jong , Wei Jeng , Shyue Song-Kun , Lee Tzong-Shyuan
Published: June 2013

The transient receptor potential vanilloid type 1 (TRPV1) is crucial in the pathogenesis of atherosclerosis; yet its role and underlying mechanism in the formation of macrophage foam cells remain unclear. Here, we show increased TRPV1 expression in the area of foamy macrophages in atherosclerotic aortas of apolipoprotein E-deficient mice. Exposure of mouse bone-marrow-derived macrophages to oxidized low-density lipoprotein (oxLDL) upregulated the expression of TRPV1. In addition, oxLDL activated TRPV1 and elicited calcium (Ca2+) influx, which were abrogated by the pharmacological TRPV1 antagonist capsazepine. Furthermore, oxLDL-induced lipid accumulation in macrophages was ameliorated by TRPV1 agonists but exacerbated by TRPV1 antagonist. Treatment with TRPV1 agonists did not affect the internalization of oxLDL but promoted cholesterol efflux by upregulating the efflux ATP-binding cassette (ABC) transporters ABCA1 and ABCG1. Moreover, the upregulation of ABC transporters was mainly through liver X receptorα- (LXRα-) dependent regulation of transcription. Moreover, the TNF-α-induced inflammatory response was alleviated by TRPV1 agonists but aggravated by the TRPV1 antagonist and LXRαsiRNA in macrophages. Our data suggest that LXRαplays a pivotal role in TRPV1-activation-conferred protection against oxLDL-induced lipid accumulation and TNF-α-induced inflammation in macrophages.
Transapical Approach for Mitral Valve Repair during Insertion of a Left Ventricular Assist Device
Authors: Russo Mark J. , Merlo Aurelie , Johnson Elizabeth M. , Akhter Shahab , McCarney Sean , Steiman Jennifer , Anderson Allen , Jeevanandam Valluvan
Published: June 2013

Background. Severe mitral regurgitation (MR) is common in patients who are undergoing insertion of a left ventricular assist device (LVAD). This study analyzes the outcomes of a transapical approach for edge‐to‐edge repair of the mitral valve during insertion of a left ventricular assist device in 19 patients with MR. Methods. This retrospective study includes 19 patients who were implanted between March 21, 2011, and August 31, 2011, at the University of Chicago. Clinical data include preoperative ejection fraction, post‐ and preoperative pulmonary arterial pressures, cardiopulmonary bypass time, post‐ and preoperative mitral regurgitation severity, endotracheal CO2, and LVAD pulse index. Results. All of the 19 patients had a reduction in mitral regurgitation. Fourteen of the 19 patients had at least a three‐point reduction in MR severity. The average postoperative pulmonary arterial pressure (PAP) decreased after the surgical procedure from 44/22 ± 14/5 mmHg to 57/28 ± 9/5 mmHg. Average CPB time was 128 ± 27 minutes. Average length‐of‐stay (LOS) was 21 ± 10 days. Conclusions. Concomitant MV repair using a transapical approach is advantageous for this small cohort of patients. The surgical procedure is less complex and has a shorter CPB time and LOS, and all of the patients demonstrated significant improvement in postoperative MR and moderate improvement in PAP.
Two-Stage Control Design of a Buck Converter/DC Motor System without Velocity Measurements via aΣ−Δ-Modulator
Authors: Silva-Ortigoza R. , García-Sánchez J. R. , Alba-Martínez J. M. , Hernández-Guzmán V. M. , Marcelino-Aranda M. , Taud H. , Bautista-Quintero R.
Published: June 2013

This paper presents a two-stage control design for the “Buck power converter/DC motor” system, which allows to perform the sensorless angular velocity trajectory tracking task. The differential flatness property of the DC-motor model is exploited in order to propose a first-stage controller, which is designed to achieve the desired angular velocity trajectory. This controller provides the voltage profiles that must be tracked by the Buck converter. Then, a second-stage controller is meant to assure the aforementioned. This controller is based on flatness property of the Buck power converter model, which provides the input voltage to the DC motor. Due to the fact that the two-stage controller proposed uses the average model of the system, as a practical and effective implementation of this controller, aΣ − Δ-modulator is employed. Finally, in order to verify the control performance of this approach, numerical simulations are included.
The Effect of Combined Antihypertensive Treatment (Felodipine with Either Irbesartan or Metoprolol) on Erectile Function: A Randomized Controlled Trial
Authors: Yang Longquan , Yu Jing , Ma Ruixin , Zhao Feng , Lin Xin , Liu Peijun , Hu Hao , Bai Feng
Published: June 2013

Objectives: This study aimed to determine whether combining a calcium channel blocker with either an angiotensin II receptor blocker or a β-blocker would have similar effects on sexual function in men with hypertension. Methods: This prospective, randomized study (ClinicalTrials.gov: NCT01​238705) included 218 male participants with untreated hypertension. Patients were randomized to treatment with felodipine combined with irbesartan or metoprolol for 48 weeks. Sexual function was evaluated at baseline and after 48 weeks of therapy. The levels of serum sex hormones and markers of oxidative stress were measured at the same time. Results: There was no significant difference in the prevalence of erectile dysfunction before and after treatment in either group (p > 0.05). There were also no differences in the levels of serum testosterone, sex hormone-binding globulin or 4-hydroxynonenal before and after treatment in either group (p > 0.05). In the felodipine-irbesartan group, sexual desire scores rose after treatment (p = 0.022) and the concentrations of serum 8-hydroxy-2′-deoxyguanosine and malondialdehyde declined (p < 0.001 and p = 0.002, respectively). The between-group differences for 8-hydroxy-2′-deoxyguanosine and malondialdehyde were not significant (p > 0.05, respectively). Conclusion: The results suggest that felodipine-irbesartan may be more beneficial to the sexual desire of hypertensive male patients than felodipine-metoprolol. This effect was possibly relevant to irbesartan, which prevents oxidative stress to some extent.