bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiometabolic risk is unraveled by color Doppler ultrasound of the clitoral and uterine arteries in women consulting for sexual symptoms
Authors: Scavello I. , Maseroli E. , Cipriani S. , Di Stasi V. , Verde N. , Menafra D. , Scannerini S. , Marchiani S. , Rastrelli G. , Ricca V. , Sorbi F. , Fambrini M. , Petraglia F. , Maggi M. , Vignozzi Linda
Published: September 2021

Female sexual dysfunction (FSD) may be a mirror of a poor cardiometabolic state. In a small pilot study enrolling 71 women with FSD, we previously demonstrated that clitoral Pulsatility Index (PI) evaluated by using color Doppler ultrasound (CDU), reflecting vascular resistance, was associated with cardiometabolic risk factors. Data on uterine CDU in this context are lacking. First, to confirm previously reported data on the direct association between clitoral PI and cardiometabolic risk factors on a larger study population of women consulting for sexual symptoms; second, to investigate eventual similar correlations between cardiometabolic risk factors and CDU parameters of the uterine artery. We also ascertained whether uterine artery PI, similarly to what had previously been observed for clitoral artery PI, was directly related to body image uneasiness and psychopathological symptoms, assessed by validated questionnaires. N = 230 women consulting our clinic for sexual symptoms were examined with clitoral CDU and blood sampling and were asked to fill out the Female Sexual Function Index, the Middlesex Hospital Questionnaire (MHQ) and the Body Uneasiness Test (BUT). In a subgroup of women (n = 164), we also performed transvaginal CDU with measurement of uterine artery parameters. At multivariate analysis, we found a direct association between clitoral PI and body mass index (BMI) (p = 0.004), waist circumference (WC) (p = 0.004), triglycerides (p = 0.006), insulin (p = 0.029) and HOMA-IR (p = 0.009). Furthermore, a correlation between obesity and Metabolic Syndrome (MetS) and a higher clitoral PI was observed (p = 0.003 and p = 0.012, respectively). Clitoral PI was also correlated with MHQ-S (p = 0.010), a scale exploring somatized anxiety symptoms, and BUT-B Positive Symptom Distress Index (p = 0.010), a measure of body image concerns. Similarly, when investigating the uterine artery, we were able to demonstrate an association between its PI and BMI (p < 0.0001), WC (p = 0.001), insulin (p = 0.006), glycated haemoglobin (p =  < 0.0001), and HOMA-IR (p = 0.009). Women diagnosed with obesity and MetS showed significantly higher uterine PI values vs. those without obesity or MetS (p = 0.001 and p = 0.004, respectively). Finally, uterine PI was associated with BUT-A Global Severity Index (p < 0.0001) and with several other BUT-A subdomains. Vascular resistance of clitoral and uterine arteries is associated with cardiometabolic risk factors and body image concerns in women consulting for sexual symptoms. If further confirmed in different populations, our data could suggest CDU, a common examination method, as a useful tool for an identification—and possible correction—of cardiometabolic risk factors.
Reduced 25-hydroxyvitamin D concentration in the aqueous humor of cataract patients with open-angle glaucoma
Authors: Cho Yongwun , Yun Seung Pil , Yoo Woong-Sun , Kim Rock-Bum , Cho Min-Chul , Kim Seong-Jae
Published: September 2021

Previous epidemiological studies have demonstrated that the lower serum concentration of vitamin D was associated with elevated risk of open-angle glaucoma (OAG). However, few studies have examined the association between aqueous humor vitamin D concentrations and OAG. Hence, we investigated the relationship between 25-hydroxyvitamin D (25(OH)D) concentrations in aqueous humor and OAG. We measured 25(OH)D concentrations in aqueous humor and serum of 126 patients who underwent cataract surgery. 36 were patients with OAG and 90 were control patients. The 25(OH)D concentrations were measured using Elecsys Vitamin D Total Kits with the Cobas e602 module (Roche Diagnostics, Mannheim, Germany), an electrochemiluminescence assay. Multiple linear regression analysis was performed to investigate factors associated with serum and aqueous humor 25(OH)D concentrations. Patients with OAG had significantly lower 25(OH)D concentrations in aqueous humor than control patients. Serum 25(OH)D concentrations were higher in patients with OAG than in the control, but this was not statistically significant. 25(OH)D concentrations in aqueous humor of patients with OAG were significantly associated with axial length but not with glaucoma severity, which was determined by the retinal nerve fiber layer thickness or mean deviation. Vitamin D concentrations in aqueous humor of patients with OAG were significantly lower than those in patients without OAG.
Single-cell profiling defines the prognostic benefit of CD39high tissue resident memory CD8+ T cells in luminal-like breast cancer
Authors: Losurdo Agnese , Scirgolea Caterina , Alvisi Giorgia , Brummelman Jolanda , Errico Valentina , Di Tommaso Luca , Pilipow Karolina , Colombo Federico Simone , Fernandes Bethania , Peano Clelia , Testori Alberto , Tinterri Corrado , Roncalli Massimo , Santoro Armando , Mazza Emilia Maria Cristina , Lugli Enrico
Published: September 2021

Luminal-like breast cancer (BC) constitutes the majority of BC subtypes, but, differently from highly aggressive triple negative BC, is poorly infiltrated by the immune system. The quality of the immune infiltrate in luminal-like BCs has been poorly studied, thereby limiting further investigation of immunotherapeutic strategies. By using high-dimensional single-cell technologies, we identify heterogeneous behavior within the tissue-resident memory CD8+ T (Trm) cells infiltrating luminal-like tumors. A subset of CD127− CD39hi Trm cells, preferentially present in the tumor compared to the adjacent normal breast tissue or peripheral blood, retains enhanced degranulation capacity compared to the CD127+ CD39lo Trm counterpart ex vivo, and is specifically associated with positive prognosis. Nevertheless, such prognostic benefit is lost in the presence of highly-suppressive CCR8hi ICOShi IRF4+ effector Tregs. Thus, combinatorial strategies aiming at boosting Trm function and infiltration while relieving from Treg-mediated immunosuppression should be investigated to achieve proper tumor control in luminal-like BCs.
The Acinetobacter baumannii disinfectant resistance protein, AmvA, is a spermidine and spermine efflux pump
Authors: Short Francesca L. , Liu Qi , Shah Bhumika , Clift Heather E. , Naidu Varsha , Li Liping , Prity Farzana T. , Mabbutt Bridget C. , Hassan Karl A. , Paulsen Ian T.
Published: September 2021

Antimicrobial resistance genes, including multidrug efflux pumps, evolved long before the ubiquitous use of antimicrobials in medicine and infection control. Multidrug efflux pumps often transport metabolites, signals and host-derived molecules in addition to antibiotics or biocides. Understanding their ancestral physiological roles could inform the development of strategies to subvert their activity. In this study, we investigated the response of Acinetobacter baumannii to polyamines, a widespread, abundant class of amino acid-derived metabolites, which led us to identify long-chain polyamines as natural substrates of the disinfectant efflux pump AmvA. Loss of amvA dramatically reduced tolerance to long-chain polyamines, and these molecules induce expression of amvA through binding to its cognate regulator AmvR. A second clinically-important efflux pump, AdeABC, also contributed to polyamine tolerance. Our results suggest that the disinfectant resistance capability that allows A. baumannii to survive in hospitals may have evolutionary origins in the transport of polyamine metabolites.
The development of tumour vascular networks
Authors: Fouladzadeh Anahita , Dorraki Mohsen , Min Kay Khine Myo , Cockshell Michaelia P. , Thompson Emma J. , Verjans Johan W. , Allison Andrew , Bonder Claudine S. , Abbott Derek
Published: September 2021

The growth of solid tumours relies on an ever-increasing supply of oxygen and nutrients that are delivered via vascular networks. Tumour vasculature includes endothelial cell lined angiogenesis and the less common cancer cell lined vasculogenic mimicry (VM). To study and compare the development of vascular networks formed during angiogenesis and VM (represented here by breast cancer and pancreatic cancer cell lines) a number of in vitro assays were utilised. From live cell imaging, we performed a large-scale automated extraction of network parameters and identified properties not previously reported. We show that for both angiogenesis and VM, the characteristic network path length reduces over time; however, only endothelial cells increase network clustering coefficients thus maintaining small-world network properties as they develop. When compared to angiogenesis, the VM network efficiency is improved by decreasing the number of edges and vertices, and also by increasing edge length. Furthermore, our results demonstrate that angiogenic and VM networks appear to display similar properties to road traffic networks and are also subject to the well-known Braess paradox. This quantitative measurement framework opens up new avenues to potentially evaluate the impact of anti-cancer drugs and anti-vascular therapies.
Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists
Authors: Sokkar Pandian , Harms Mirja , Stürzel Christina , Gilg Andrea , Kizilsavas Gönül , Raasholm Martina , Preising Nico , Wagner Manfred , Kirchhoff Frank , Ständker Ludger , Weidinger Gilbert , Mayer Benjamin , Münch Jan , Sanchez-Garcia Elsa
Published: September 2021

EPI-X4, a 16-mer fragment of albumin, is a specific endogenous antagonist and inverse agonist of the CXC-motif-chemokine receptor 4 (CXCR4) and thus a key regulator of CXCR4 function. Accordingly, activity-optimized synthetic derivatives of EPI-X4 are promising leads for the therapy of CXCR4-linked disorders such as cancer or inflammatory diseases. We investigated the binding of EPI-X4 to CXCR4, which so far remained unclear, by means of biomolecular simulations combined with experimental mutagenesis and activity studies. We found that EPI-X4 interacts through its N-terminal residues with CXCR4 and identified its key interaction motifs, explaining receptor antagonization. Using this model, we developed shortened EPI-X4 derivatives (7-mers) with optimized receptor antagonizing properties as new leads for the development of CXCR4 inhibitors. Our work reveals the molecular details and mechanism by which the first endogenous peptide antagonist of CXCR4 interacts with its receptor and provides a foundation for the rational design of improved EPI-X4 derivatives.
Emerging SARS-CoV-2 variants follow a historical pattern recorded in outgroups infecting non-human hosts
Authors: Katoh Kazutaka , Standley Daron M.
Published: September 2021

The ability to predict emerging variants of SARS-CoV-2 would be of enormous value, as it would enable proactive design of vaccines in advance of such emergence. We estimated diversity of each site on a multiple sequence alignment (MSA) of the Spike (S) proteins from close relatives of SARS-CoV-2 that infected bat and pangolin before the pandemic. Then we compared the locations of high diversity sites in this MSA and those of mutations found in multiple emerging lineages of human-infecting SARS-CoV-2. This comparison revealed a significant correspondence, which suggests that a limited number of sites in this protein are repeatedly substituted in different lineages of this group of viruses. It follows, therefore, that the sites of future emerging mutations in SARS-CoV-2 can be predicted by analyzing their relatives (outgroups) that have infected non-human hosts. We discuss a possible evolutionary basis for these substitutions and provide a list of frequently substituted sites that potentially include future emerging variants in SARS-CoV-2.
X-ray scattering from light-driven spin fluctuations in a doped Mott insulator
Authors: Wang Yao , Chen Yuan , Devereaux Thomas P. , Moritz Brian , Mitrano Matteo
Published: September 2021

Manipulating spin fluctuations with ultrafast laser pulses is a promising route to dynamically control collective phenomena in strongly correlated materials. However, understanding how photoexcited spin degrees of freedom evolve at a microscopic level requires a momentum- and energy-resolved characterization of their nonequilibrium dynamics. Here, we study the photoinduced dynamics of finite-momentum spin excitations in two-dimensional Mott insulators on a square lattice. By calculating the time-resolved resonant inelastic x-ray scattering cross-section, we show that an ultrafast pump above the Mott gap induces a prompt softening of the spin excitation energy, compatible with a transient renormalization of the exchange interaction. While spin fluctuations in a hole-doped system (paramagnons) are well described by Floquet theory, magnons at half filling are found to deviate from this picture. Furthermore, we show that the paramagnon softening is accompanied by an ultrafast suppression of d-wave pairing correlations, indicating a link between the transient spin excitation dynamics and superconducting pairing far from equilibrium.
Reduced subgenomic RNA expression is a molecular indicator of asymptomatic SARS-CoV-2 infection
Authors: Wong Chee Hong , Ngan Chew Yee , Goldfeder Rachel L. , Idol Jennifer , Kuhlberg Chris , Maurya Rahul , Kelly Kevin , Omerza Gregory , Renzette Nicholas , De Abreu Francine , Li Lei , Browne Frederick A. , Liu Edison T. , Wei Chia-Lin
Published: September 2021

Background

It is estimated that up to 80% of infections caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are asymptomatic and asymptomatic patients can still effectively transmit the virus and cause disease. While much of the effort has been placed on decoding single nucleotide variation in SARS-CoV-2 genomes, considerably less is known about their transcript variation and any correlation with clinical severity in human hosts, as defined here by the presence or absence of symptoms.

Methods

To assess viral genomic signatures of disease severity, we conducted a systematic characterization of SARS-CoV-2 transcripts and genetic variants in 81 clinical specimens collected from symptomatic and asymptomatic individuals using multi-scale transcriptomic analyses including amplicon-seq, short-read metatranscriptome and long-read Iso-seq.

Results

Here we show a highly coordinated and consistent pattern of sgRNA expression from individuals with robust SARS-CoV-2 symptomatic infection and their expression is significantly repressed in the asymptomatic infections. We also observe widespread inter- and intra-patient variants in viral RNAs, known as quasispecies frequently found in many RNA viruses. We identify unique sets of deletions preferentially found primarily in symptomatic individuals, with many likely to confer changes in SARS-CoV-2 virulence and host responses. Moreover, these frequently occurring structural variants in SARS-CoV-2 genomes serve as a mechanism to further induce SARS-CoV-2 proteome complexity.

Conclusions

Our results indicate that differential sgRNA expression and structural mutational burden are highly correlated with the clinical severity of SARS-CoV-2 infection. Longitudinally monitoring sgRNA expression and structural diversity could further guide treatment responses, testing strategies, and vaccine development.
Liposome fusion with orthogonal coiled coil peptides as fusogens: the efficacy of roleplaying peptides
Authors: Daudey Geert A. , Shen Mengjie , Singhal Ankush , van der Est Patrick , Sevink G. J. Agur , Boyle Aimee L. , Kros Alexander
Published: September 2021

We developed a liposomal fusion model system with specific recognition using a set of heterodimeric coiled coil peptide pairs. This study unravels important structure–fusogenic efficacy relationships of peptide fusogens.
An electrochemical aptasensor for the milk allergen β-lactoglobulin detection based on a target-induced nicking site reconstruction strategy
Authors: Qiu Qianying , Ni Xiao , Liu Tianchen , Li Zening , An Xinyi , Chen Xiaojun
Published: September 2021

A novel electrochemical aptasensor was fabricated for the quantitative detection of β-lactoglobulin, based on target-induced nicking site reconstruction strategy accompanied with nicking enzyme activated hybridization chain reaction amplification.
Correction: Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications
Authors: Berry Matthew E. , Kearns Hayleigh , Graham Duncan , Faulds Karen
Published: September 2021

Correction for ‘Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications’ by Matthew E. Berry et al., Analyst, 2021, DOI: 10.1039/D1AN00865J.
Development of highly sensitive and selective bisphenol A sensor based on a cobalt phthalocyanine-modified carbon paste electrode: application in dairy analysis
Authors: Jemmeli Dhouha , Dridi Chérif , Abbas Mohammed N. , Dempsey Eithne
Published: September 2021

Simple, sustainable & cost-effective BPA sensor development for milk analysis.
Aortic aneurysm evaluation by scanning acoustic microscopy and Raman spectroscopy
Authors: Tanoren Bukem , Parlatan Ugur , Parlak Melita , Kecoglu Ibrahim , Unlu Mehmet Burcin , Oztas Didem Melis , Ulukan Mustafa Ozer , Erkanli Korhan , Ugurlucan Murat
Published: September 2021

(a) Acoustic impedance map of an aorta sample by SAM. (b) Correlation between SAM and RS measurements. As age increases, signals obtained by both techniques increase with similar trends.
High-performance ZnCo2O4 microsheets as an anode for lithium-ion batteries
Authors: Kang Ying , Shi Hongwei , Zhang Yu-Hang , Shi Fa-Nian
Published: September 2021

Mesoporous ZnCo2O4 microsheets are successfully obtained by using a MOF as a precursor.
Strong intermolecular interaction induced methylene-bridged asymmetric heterocyclic explosives
Authors: Wang Yu , Ye Jin , Yang Na , Ma Haixia , Zhang Yazhou , Guo Zhaoqi
Published: September 2021

Methylene-bridged asymmetric heterocyclic explosives were designed and synthesized to attempt the possibility of realizing energetic materials with high-energy and adequate sensitivity.
Dynamical calculations of O(3P) + OH(2Π) reaction on the CHIPR potential energy surface using the fully coupled time-dependent wave-packet approach in hyperspherical coordinates
Authors: Ghosh Sandip , Sharma Rahul , Adhikari Satrajit , Varandas António J. C.
Published: September 2021

Using the rate constant obtained by fully coupled 3D time-dependent wavepacket method for forward and backward reactions, we calculate Keq(T) for the reversible process [H + O2 ⇌ O + OH] and compare with experimental measurements.
Reaction of nitric oxide molecules on transition-metal-doped silver cluster cations: size- and dopant-dependent reaction pathways
Authors: Arakawa Masashi , Horioka Masataka , Minamikawa Kento , Kawano Tomoki , Terasaki Akira
Published: September 2021

A rich variety of reaction channels is observed for AgnM+ interacting with NO, ranging from the character of the dopant atom modified by the presence of Ag atoms at small sizes through the behaviors of undoped Ag clusters at large sizes.
High-performance lithium–sulfur batteries enabled by regulating Li2S deposition
Authors: Lin Qiaowei , Huang Ling , Liu Wenhua , Li Zejian , Fang Ruopian , Wang Da-Wei , Yang Quan-Hong , Lv Wei
Published: September 2021

This perspective highlights the significance of regulating Li2S deposition and the related methods in improving the performance of lithium–sulfur batteries.
Quantitative electronic structure and work-function changes of liquid water induced by solute
Authors: Credidio Bruno , Pugini Michele , Malerz Sebastian , Trinter Florian , Hergenhahn Uwe , Wilkinson Iain , Thürmer Stephan , Winter Bernd
Published: September 2021

Significant differences are observed in liquid-water's lowest electron binding energy with increasing solute concentration in archetypal aqueous solutions. For NaI(aq) and TBAI(aq), the energy changes extend to +0.3 eV and −0.7 eV, respectively.
Green light (550 nm) driven tunable syngas synthesis from CO2 photoreduction using heterostructured layered double hydroxide/TiC photocatalysts
Authors: Wang Huijuan , Bai Sha , Zhao Pu , Tan Ling , Ning Chenjun , Liu Guihao , Wang Jikang , Shen Tianyang , Zhao Yufei , Song Yu-Fei
Published: September 2021

Under visible light, LDH/TiC photocatalysts were prepared and exhibited tunable syngas synthesis with different CO/H2 ratios.
Al-Modified Ti-MOR as a robust catalyst for cyclohexanone ammoximation with enhanced anti-corrosion performance
Authors: Peng Rusi , Wan Zhipeng , Lv Huanzhi , Guan Yejun , Xu Hao , Wu Peng
Published: September 2021

The skeleton desilication accompanied by Ti active sites leaching accounts for the dominant chemical deactivation reasons in the alkali liquid-phase ammoximation, which could be retarded by creating a protective Al-rich shell.
Physicochemical properties of seed protein isolates extracted from pepper meal by pressure-assisted and conventional solvent defatting
Authors: Wang Fengzhang , Ma Yan , Wang Yongtao , Zhao Liang , Liao Xiaojun
Published: September 2021

A pressure-assisted defatting (PAD) method improved the physicochemical and functional properties of pepper seed protein isolates.
Metformin and cyanidin 3-O-galactoside fromAronia melanocarpasynergistically alleviate cognitive impairment in SAMP8 mice
Authors: Wen Haichao , Tian Hehe , Liu Chang , Zhang Xiaoxu , Peng Yao , Yang Xinquan , Chen Feng , Li Jingming
Published: September 2021

Cyanidin 3-O-galactoside (Cy3Gal) fromAronia melanocarpaand coadministration of metformin had a neuroprotective effect and alleviated cognitive impairment in the SAMP8 mice, and regulated the metabolites in feces and urine.
Pectic polysaccharide fromNelumbo nuciferaleaves promotes intestinal antioxidant defensein vitroandin vivo
Authors: Huang Chao , Peng Xi , Pang De-Jiang , Li Juan , Paulsen Berit Smestad , Rise Frode , Chen Yu-Long , Chen Zheng-Li , Jia Ren-Yong , Li Li-Xia , Song Xu , Feng Bin , Yin Zhong-Qiong , Zou Yuan-Feng
Published: September 2021

A pectic polysaccharide NNLP-I-I from lotus leaves exhibited antioxidant property through regulating Nrf2-mediated intestinal antioxidant defense system, which will be valuable for its further applications on the treatments of intestinal diseases.
Nuciferine administration in C57BL/6J mice with gestational diabetes mellitus induced by a high-fat diet: the improvement of glycolipid disorders and intestinal dysbacteriosis
Authors: Tang Zhuohong , Luo Ting , Huang Peng , Luo Mi , Zhu Jianghua , Wang Xing , Lin Qingmei , He Zihao , Gao Pingming , Liu Shuwen
Published: September 2021

Improvement of glycolipid disorders and gut dysbacteriosis by nuciferine in high-fat diet-induced gestational diabetes mellitus mice.
Pd/β-cyclodextrin-catalyzed C–H functionalization in water: a greener approach to regioselective arylation of (NH)-indoles with aryl bromides
Authors: Xu Peng , Duan Xin Hong
Published: September 2021

A greener and more practical approach to the regioselective C3/C2-arylation of (NH)-indoles with (hetero)aryl bromides in water is developed via the Na2PdCl4-catalyzed and β-cyclodextrin ligand-mediated cross-coupling reactions.
Copolymers based on trialkylsilylethynyl-phenyl substituted benzodithiophene building blocks for efficient organic solar cells
Authors: Liu Haifen , Zhu Zixuan , Li Huafeng , Fan Weili , Ning Kaihua , Su Chao , Ren Jingpeng , Wang Lixin
Published: September 2021

Trialkylsilylethynyl-phenyl was explored as a side chain to construct a benzodithiophene-containing polymer that demonstrated a PCE of 7.81% in organic solar cells.
Selective capturing and fluorescence “turn on” detection of dibutyl phthalate using a molecular imprinted nanocomposite
Authors: Dolai Jayanta , Ali Haydar , Jana Nikhil R.
Published: September 2021

Fluorescence-based selective detection of dibutyl phthalate is achieved via a paper-strip-based approach.
Designing 3D-nanosubstrates mimicking biological cell growth: pitfalls of using 2D substrates in the evaluation of anticancer efficiency
Authors: Patil Ashwini , Nandi Semonti , Kale Narendra , Bobade Chandrashekhar , Banerjee Shashwat , Patil Yuvraj , Khandare Jayant
Published: September 2021

Substrate nanoarchitecture can mimic the tissue microenvironment and promote a three-dimensional cellular growth pattern superior to conventional 2D support systems.
Tuning photoluminescence spectra of MoS2 with liquid crystals
Authors: Yu Jeong-Seon , Hwang Jea-Jun , Lee Jun-Yong , Ha Dong Han , Kim Jong-Hyun
Published: September 2021

The liquid crystal texture on molybdenum disulfide (MoS2). And the photoluminescence and Raman spectra of MoS2 are shifted with liquid crystals.
The multifunctional design of metal–organic framework by applying linker desymmetrization strategy: synergistic catalysis for high CO2-epoxide conversion
Authors: Zhu Yueying , Gu Jiaming , Yu Xueyue , Zhang Borong , Li Guanghua , Li Jiantang , Liu Yunling
Published: September 2021

A novel copper-organic framework was synthesized by a linker desymmetrization strategy. Synergistic catalysis with Lewis and Brønsted acid sites promoted a high catalytic efficiency towards the CO2-propylene oxide cycloaddition reaction.
Correction: Insights into the chiral sulfide/selenide-catalyzed electrophilic carbothiolation of alkynes: mechanism and origin of axial chirality
Authors: Zhang Qiao-Yu , Li Shi-Jun , Wang Yang , Song Jinshuai , Lan Yu , Wei Donghui
Published: September 2021

Correction for ‘Insights into the chiral sulfide/selenide-catalyzed electrophilic carbothiolation of alkynes: mechanism and origin of axial chirality’ by Qiao-Yu Zhang et al., Org. Chem. Front., 2021, 8, 1983–1990, DOI: 10.1039/D1QO00036E.
Mannich bases of hydroxycoumarins: synthesis, DFT/QTAIM computational study and assessment of biological activity
Authors: Durand-Niconoff J. Sergio , Ortiz-Blanco Erik , Sosa-Ortiz Gabriela , Olivares-Romero José L. , Juárez-Aguilar Enrique , Montoya-Hernández Eva Luz , Fernández-Pomares Cynthia , Tovar-Miranda Ricardo , Castro María Eugenia , Melendez Francisco J. , Guerrero Tomás
Published: September 2021

Mannich bases derived from hydroxycoumarins as interesting scaffolds for several applications.
Solvent extraction of rare earths elements from nitrate media in DMDOHEMA/ionic liquid systems: performance and mechanism studies
Authors: Usma Cesar L. , Dourdain S. , Arrachart G. , Pellet-Rostaing S.
Published: September 2021

Extraction of La(iii), Eu(iii) and Fe(iii) was compared in n-dodecane and in two ionic liquids (ILs) [EBPip+] [NTf2−] and [EOPip+] [NTf2−]. Extraction mechanisms have been investigated as a function of pH.
Tetrazol-Cu(i) immobilized on nickel ferrite catalyzed green synthesis of indenopyridopyrimidine derivatives in aqueous media
Authors: Ghanbari Zahra , Naeimi Hossein
Published: September 2021

In this protocol, a novel nanocatalyst was very effective in progression of the reaction and increasing efficiency. This green approach in aqueous media has several advantages compared with the reported methods.
Polyvalent spherical aptamer engineered macrophages: X-ray-actuated phenotypic transformation for tumor immunotherapy
Authors: Chen Yuanyuan , Gao Peng , Pan Wei , Shi Mingwan , Liu Shujie , Li Na , Tang Bo
Published: September 2021

An X-ray-induced phenotypic transformation strategy (X-PT) through macrophage engineering was developed for safe and effective immunotherapy.
Self-assembled cationic organic nanosheets: role of positional isomers in a guanidinium-core for efficient lithium-ion conduction
Authors: Dey Ananta , Ramlal Vishwakarma Ravikumar , Sankar Selvasundarasekar Sam , Kundu Subrata , Mandal Amal Kumar , Das Amitava
Published: September 2021

Self-assembled organic nanosheets (SONs) having a near-atomic thickness (∼4.5 nm) are obtained through exfoliation. Among two positional isomers of the guanidinium-core analogue used for SONs, one shows greatly improved Li+ ion conductivity.
Semi-batch and continuous production of Pickering emulsion via direct contact steam condensation
Authors: Madhavan Nithin , Yalla Eswararao , Pushpavanam S. , Renganathan T. , Mukherjee Manas , Basavaraj Madivala G.
Published: September 2021

We propose a versatile strategy for the production of highly stable water in oil Pickering emulsion by direct contact condensation of steam.
Application of two-dimensional materials in perovskite solar cells: recent progress, challenges, and prospective solutions
Authors: Ali Ahmad Syed Ossama , Ashfaq Atif , Akbar Muhammad Usama , Ikram Mujtaba , Khan Karim , Wang Feng , Ikram Muhammad , Mahmood Asif
Published: September 2021

Perovskite solar cells (per-SCs) with high performance and cost-effective solution processing have been the center of interest for researchers in the past decade.
Y2(Ge,Si)O5:Pr phosphors: multimodal temperature and pressure sensors shaped by bandgap management
Authors: Sójka Małgorzata , Runowski Marcin , Woźny Przemysław , Carlos Luis D. , Zych Eugeniusz , Lis Stefan
Published: September 2021

Deliberate managing of luminescent parameters for precise measurements of the two physical quantities executed by the bandgap engineering varying Ge:Si proportion in the Y2(Gex,Si1-x)O5:Pr phosphor.
Optical fiber sensor based on upconversion nanoparticles for internal temperature monitoring of Li-ion batteries
Authors: Li Hanyang , Wei Feng , Li Yanzeng , Yu Miao , Zhang Yu , Liu Lu , Liu Zhihai
Published: September 2021

Real-time monitoring of the internal temperature of a battery with an optical fiber sensor based on β-NaYF4:Er3+/Yb3+@NaYF4 nanoparticles.
The precursor-compensation strategy boosts the photoresponse performance of air-stable, self-powered Cs2SnI6 photodetectors
Authors: Huang Junyi , Dong Chen , Mei Yantao , Lu Xiayao , Yue Gentian , Gao Yueyue , Liu Rong , Zhang Weifeng , Tan Furui
Published: September 2021

A facile precursor-compensation treatment (PCT) strategy is developed to prepare pure-phase and dense Cs2SnI6 films. A photodetector based on a PCT-Cs2SnI6 film exhibits enhanced photoresponse performance and excellent operation stability.
Making the invisible visible: exploring host–microbiome interactions across different taxa using data-driven 3D visualization
Authors: Landis Susanne H. , Duscher Tom , Bosch Thomas C.G.
Published: September 2021

The importance of microbiome research is rapidly gaining momentum for understanding its role in development, evolution, ecology, health and disease. Recent progress in community and single-cell genomic approaches has provided an unprecedented amount of information on the abundance and ecology of microbes in different host organisms and turned them into metaorganisms. A metaorganism is a host and its complete microbial community which is commonly referred to as the microbiome. Over half the cells in a human body are not human but belong to the multitude of species that compose our microbiome. However, linkages between metaorganisms from different taxa and their in situ level of intraspecific dependence (be it growth, division or metabolic activity) are much more scarce. Visualization therefore is crucial for understanding host–microbe interactions as well as overarching concepts in different host organisms. Here we introduce an innovative user-friendly method for interactive visualization of microbiome multi-omics data. The new communication format combines science and visual communication design. Interactive media are used to transform scientific findings on host–microbe interactions in an intuitive way. The method provides access to additional layers of information that cannot be visualized using a traditional platform. We demonstrate the usefulness of this visualization approach using the interactive scientific poster ‘Digital Meta’, which is designed to support not only interdisciplinary co-working but also communication with the general public.
Selective HIF stabilization alleviates hepatocellular steatosis and ballooning in a rodent model of 70% liver resection
Authors: Iesari Samuele , Leclercq Isabelle , Joudiou Nicolas , Komuta Mina , Daumerie Aurélie , Ambroise Jérôme , Dili Alexandra , Feza-Bingi Natacha , Xhema Daela , Bouzin Caroline , Gallez Bernard , Pisani Francesco , Bonaccorsi-Riani Eliano , Gianello Pierre
Published: September 2021

Background: Small-for-size syndrome (SFSS) looms over patients needing liver resection or living-donor transplantation. Hypoxia has been shown to be crucial for the successful outcome of liver resection in the very early postoperative phase. While poorly acceptable as such in real-world clinical practice, hypoxia responses can still be simulated by pharmacologically raising levels of its transducers, the hypoxia-inducible factors (HIFs).

We aimed to assess the potential role of a selective inhibitor of HIF degradation in 70% hepatectomy (70%Hx).

Methods: In a pilot study, we tested the required dose of roxadustat to stabilize liver HIF1α. We then performed 70%Hx in 8-week-old male Lewis rats and administered 25 mg/kg of roxadustat (RXD25) at the end of the procedure. Regeneration was assessed: ki67 and 5-ethynyl-2′-deoxyuridine (EdU) immunofluorescent labeling, and histological parameters. We also assessed liver function via a blood panel and functional gadoxetate-enhanced magnetic resonance imaging (MRI), up to 47 h after the procedure. Metabolic results were analyzed by means of RNA sequencing (RNAseq).

Results: Roxadustat effectively increased early HIF1α transactivity. Liver function did not appear to be improved nor liver regeneration to be accelerated by the experimental compound. However, treated livers showed a mitigation in hepatocellular steatosis and ballooning, known markers of cellular stress after liver resection. RNAseq confirmed that roxadustat unexpectedly increases lipid breakdown and cellular respiration.

Conclusions: Selective HIF stabilization did not result in an enhanced liver function after standard liver resection, but it induced interesting metabolic changes that are worth studying for their possible role in extended liver resections and fatty liver diseases.
Incremental multi‐view correlated feature learning based on non‐negative matrix factorisation
Authors: Zhao Liang , Yang Tao , Zhang Jie , Chen Zhikui
Published: September 2021

In real‐world applications, large amounts of data from multiple sources come in the form of streams. This makes multi‐view feature learning cost much time when new instances rise incrementally. Dealing with these growing multi‐view data becomes a challenging problem. Some single‐view methods focus on processing the data dynamically, but they are not suitable for multi‐view data. Some online multi‐view methods are proposed to tackle it, but they ignore the influence of uncorrelated items in each view. Therefore, in this study, the authors propose a new algorithm, called Incremental Multi‐view Correlated Feature Learning (IMCFL) based on non‐negative matrix factorisation, to learn the common feature across views. By separating uncorrelated items of new instances and constructing incremental joint learning of correlated and uncorrelated features, the proposed IMCFL can eliminate the influence of uncorrelated information in the individual view and improve the effectiveness of incremental multi‐view common feature learning. Extensive experiments on real‐world datasets confirm its superiority by comparing it with other state‐of‐the‐art incremental and non‐incremental methods.
Learning spatial self‐attention information for visual tracking
Authors: Li Shengwu , Zhang Xuande , Xiong Jing , Ning Chenjing , Zhang Mingke
Published: September 2021

Visual object tracking has been a fundamental topic in computer vision and many convolutional neural network (CNN) based trackers proposed in recent years have achieved state‐of‐the‐art performance, multi‐domain convolutional neural network (MDNet) is one of the most representative CNN‐based algorithms with high performance. In order to significantly improve the robustness and accuracy of the MDNet algorithm, a multi‐domain convolutional neural network based on spatial self‐attention information learning (SAMDNet) is proposed in this study. The authors use the spatial self‐attention module for the spatial information learning of the model. The spatial self‐attention module selectively aggregates the feature at each position by a weighted sum of the features at all positions. Under the control of self‐learning parameters in this module, spatial attention information can be flexibly acquired. The authors also propose a novel interval loss term to solve the problem of different classes with the same semantics in the training data. Finally, an anomaly detection module is carefully designed for relocation after the algorithm completely lost the target. Extensive experiments on the object tracking benchmark (OTB) and the visual object tracking challenge (VOT) benchmarks show that the proposed tracker outperforming most of the state‐of‐art trackers.
DDoS Detection on Internet of Things using Unsupervised Algorithms
Authors: Tekleselassie Hailyie
Published: September 2021

Through the growth of the fifth-generation networks and artificial intelligence technologies, new threats and challenges have appeared to wireless communication system, especially in cybersecurity. And IoT networks are gradually attractive stages for introduction of DDoS attacks due to integral frailer security and resource-constrained nature of IoT devices. This paper emphases on detecting DDoS attack in wireless networks by categorizing inward network packets on the transport layer as either “abnormal” or “normal” using the integration of machine learning algorithms knowledge-based system. In this paper, deep learning algorithms and CNN were autonomously trained for mitigating DDoS attacks. This paper lays importance on misuse based DDOS attacks which comprise TCP SYN-Flood and ICMP flood. The researcher uses CICIDS2017 and NSL-KDD dataset in training and testing the algorithms (model) while the experimentation phase. accuracy score is used to measure the classification performance of the four algorithms. the results display that the 99.93 performance is recorded.
Numerical study of the efficiency of integrating phase change material into a clay-straw wall in the Drâa-Tafilalet region (Errachidia Province)
Authors: Ben Zaid Zaineb , Tilioua Amine , Ansari Omar , Lamaamar Ibtissam , Hamdi Alaoui Moulay Ahmed
Published: September 2021

The objective of this study is to evaluate the thermal performance of clay-straw walls of buildings integrating phase change materials (PCM). The influence of integrating different types of PCM in the envelope has been studied numerically in several studies. The optimal wall thickness with PCM integrated suitable for the climatic conditions of Errachidia has been studied. The heat balance equations for the different wall configurations are formulated and solved numerically under the same climatic conditions. The results obtained show that the integration of PCM in the clay-straw wall instead of the cement wall increases the heat flux density as a function of time by up to 80 % based on the thermal properties of the PCM and the environmental conditions of the study.
Structural and dynamical properties simulations of potassium fluoride aqueous system at various temperatures from 298.15 K to 358.15 K
Authors: Errougui Abdelkbir , Talbi Mohammed , El Kouali M’hammed
Published: September 2021

The energy storage systems are dominated by lithium–ion based chemistry. Currently, the focus has shifted to its nearest neighbours and extensive studies have been carried out on sodium and potassium ion-based batteries. Incorporation of potassium fluoride into solar cells (CIGS) improves the conversion efficiency by increasing the majority carrier concentration. In this study, we present results from molecular dynamics simulations of water solutions and clusters containing potassium fluoride with the interatomic interactions described by OPLS-AA force field for understanding the mechanisms of the physical phenomena of these ionic complexes. The structural and dynamical properties of KF solutions have been studied at various temperatures using TIP4P water model and the ions which are modeled as charged Lennard-Jones particles. The analysis of the simulation results showed that the temperature has decisive effects on the physicochemical properties of the KF electrolyte in aqueous solutions.
Improving electrical energy and producing thermal energy in solar photovoltaic system by integrating phase change materials
Authors: Hassoune Hind , Ben zohra Mouna , Riad Amine , Alhamanyi Abdelilah
Published: September 2021

Solar energy is a natural source that provides clean and renewable energy, which supplies two types of energy: thermal energy and photovoltaic energy. Whereas, the most effective way to exploit this energy is photovoltaic cells. However, for all the incident solar radiation, the solar panels can absorb a limited quantity of energy. While, the rest of radiation energy gets lost as heat, that increases the temperature of the photovoltaic cells, this is the reason why the productivity of electricity is decreased. Therefore, to exceed this issue and benefit from the two sources of sun radiation, a hybrid thermo-electrical system is proposed. The system is a solar panel surrounded by the phase change material that can absorb the temperature to increase the efficiency of solar system and use this energy to produce a hot water.
New Practical Teaching Model Design for mutualized practical works based on low cost ICT, IoT and AI developed solutions
Authors: Mehdi Laraki , Youssef Sekhara , Soufiane Guessous
Published: September 2021

Recently, Information and Communication Technology (ICT) plays a crucial role in teaching-learning, particularly tracking, trainings, knowledge management and knowledge organization. The aim of this article is to propose a new practical teaching model design for practical works based on ICT, IoT and AI Tools. This new model will allow students to acquire skills and knowledges outside their field of training related to their course. The challenge of this teaching model is to teach more practical works by adopting the learning by doing approach, with a minimum cost effect.
Finite frequency model reduction for 2-D fuzzy systems in FM model
Authors: Naoual Rachid , El-Amrani Abderrahim , Boumhidi Ismail
Published: September 2021

This paper deals with the problem ofH∞model reduction for two-dimensional (2D) discrete Takagi-Sugeno (T-S) fuzzy systems described by Fornasini-Marchesini local state-space (FM LSS) models, over finite frequency (FF) domain. New design conditions guaranteeing the FFH∞model reduction are established in terms of Linear Matrix Inequalities (LMIs). To highlight the effectiveness of the proposedH∞model reduction design, a numerical example is given.
A low-cost IMU/GPS position accuracy experimental study using extended kalman filter data fusion in real environments
Authors: El Fatimi Aziz , Addaim Adnane , Guennoun Zouhair
Published: September 2021

In a three-dimensional environment, the navigation of a vehicle in airspace, terrestrial space, or maritime space presents complex aspects concerning the determination of its position, its orientation, and the stability of the processing of the asynchronous data coming from the various sensors during navigation. In this context, this paper presents an experimental analysis of the position accuracy estimated by a low-cost inertial measurement unit coupled, by the extended Kalman data fusion algorithm, with a system of absolute measurements of a positioning system received from a GPS which designates the global positioning system. The different scenarios of the experimental study carried out during this work concerned three tests in a real environment, such as the navigation in a course inside the city of Rabat/Morocco with a moderate speed, a section on the highway at a speed of 120 Km/h and a circular path around a roundabout. The experimental results proved that the low-cost sensors studied are a good candidate for civil navigation applications.
A New Symmetric Key Cryptographic Algorithm using Paley Graphs and ASCII Values
Authors: Oumazouz Zhour , Karim Driss
Published: September 2021

The main objective of the study conducted in this article is to introduce a new algorithm of encryption and decryption of a sensitive message after transforming it into a binary message. Our proposed encryption algorithm is based on the study of a particular graph constructed algebraically from the quadratic residues. We have exploited the Paley graph to introduce an abstract way of encryption of such message bit according to the other message bits by the intermidiate study of the neighborhood of a graph vertex. The strong regularity of the Paley graphs and the unknown behavior of the quadratic residues will play a very important role in the cryptanalysis part which allows to say that the brute force attack remains for the moment the only way to obtain the set of possible messages.
Architectural scheme of a multi-blockchain in the Agricultural field
Authors: El Mane Adil , Chihab Marouane , Bencharef Omar , Chihab Younes
Published: September 2021

The blockchain represents structured and shared data. Instantly, it is a modern method of distributed databases controlled by a group of individuals. The goal is to store information, create a digital ledger of data, and dispatch them to each network-independent party. Blockchain technology gets used in many fields like government, transportation, healthcare, etc. This article will focus on the blockchain in the agricultural supply chain, especially the multi-blockchain scheme to enhance efficiency and track products. This kind of scheme requires the existence of two chains at least in one system. The article analyzes previous researches on how implementing this model and cites its various steps. Also, this research will offer a novel theoretical architecture inspired by the previous ones. The novel structure will avoid the errors that exist in previous experiments. This novel theoretical scheme uses sensors to provide us with environmental data. Subsequently, we use the multi-blockchain structure to stock our data in blocks. After that, we build Smart Contracts to control all the transactions and make decisions based on the conditions inside the source code of these automated contracts. This scheme would be more effective than the cloud and the simple blockchain storage.
Power Adjustment Algorithm for Higher Throughput in Mobile Ad-Hoc Networks
Authors: Saravanan K. , Anthoniraj S. , Kumarganesh S. , Kumar T.Senthil , Sagayam K. Martin
Published: September 2021

In Mobile Ad Hoc Networks (MANETs), power control is necessary in order to reduce power consumption rates, avoid collisions within packets, increase spatial throughput of the system and to reduce contention among flows. The MANET nodes which are outside the transmission range are energy constraint and they consume more power for packet transmission. In this paper, we propose to develop a power adjustment algorithm to provide higher throughput and consume less power in the Mobile Ad hoc Networks. An optimal transmission power is calculated at the receiver based upon the data payload length and the interference amount. This power is given to the transmitter which increments or decrements the power with respect to the number of neighboring nodes. The adjusted power is retransmitted to the receiver so that the power level can be adjusted between the transmitter and receiver. Since the optimal transmission power is determined based upon the interference amount the possibility of collision among the nodes is reduced effectively. From our simulation results, we show that this algorithm provides higher throughput and lower energy consumption in ad hoc networks.