bluuebunny/crossref_metadata_2025 huggingface dataset:
Cnicin from Centaurea benedicta L. is an active compound against skin inflammation in a mouse model
Authors: Sousa Orlando Vieira , Gonçalves Guilherme C. , Queiroz Lucas S. , Ferreira Everton A. , Santos Bruna C. S. , Filho Ademar A. Silva , Taranto Alex G.
Published: December 2021

Centaurea benedicta L., commonly known as “cardo santo,” is used as a tonic, antidepressant, anti-inflammatory, antibacterial, and antiseptic in traditional medicine. This study evaluated the topical anti-inflammatory potential of an extract (ECB) and cnicin (CNI) from C. benedicta leaves in a mouse model. Activity was assessed using the ear edema method with croton oil, phenol, capsaicin, and histamine as phlogistic agents. Myeloperoxidase (MPO), N-acetyl-β-D-glucosaminidase (NAG), nitric oxide (NO), t umor necrosis factor α (TNF-α), interleukin 6 (IL-6), and histopathology were assessed as markers of edema/inflammation. Interaction profiles between CNI and cyclooxygenase-1 and -2, induced nitric oxide synthase, and glucocorticoid receptor were examined with molecular docking. Twenty-four h after induction of inflammation, ECB and CNI treatments decreased the thickness and weight of ears by 39.59%– 94.72%. MPO, NAG, NO, TNF-α, and IL-6 levels were also reduced. Histopathological, treatments reduced edema thickness, leukocytes, and vasodilation. Inflammation induced by phenol and histamine was inhibited by ECB and CNI, and ECB suppressed capsaicin-induced inflammation. CNI interacts with cyclooxygenase-1 and nitric oxide synthase through conventional hydrogen bonds, indicating inhibition of these enzymes. ECB and its compound cnicin reduce chemically-induced inflammation in mice suggesting new possibilities for the treatment of diseases associated with dermal inflammatory processes.
Seroconversion following the first, second, and third dose of SARS-CoV-2 vaccines in immunocompromised population; A systematic review and meta-analysis
Authors: Nejad Mohammad-Mehdi Mehrabi , Shobeiri Parnian , Dehghanbanadaki Hojat , Tabary Mohammadreza , Aryannejad Armin , Ghadery Abdolkarim Haji , Shabani Mahya , Moosaie Fatemeh , SeyedAlinaghi SeyedAhmad , Rezaei Nima
Published: December 2021

Background: Immunocompromised (IC) patients are at higher risk of more severe COVID-19 infections than the general population. Special considerations should be dedicated to such patients. We aimed to investigate the efficacy of COVID-19 vaccines based on the vaccine type and etiology as well as necessity of booster dose in this high-risk population.Materials and methods: We searched PubMed, Web of Science, and Scopus databases for observational studies published between June 1st, 2020, and September 1st, 2021, which investigated the seroconversion after COVID-19 vaccine administration in adult patients with IC conditions. For investigation of sources of heterogeneity, subgroup analysis and sensitivity analysis were conducted. Statistical analysis was performed using R software.Results: According to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, we included 81 articles in the meta-analysis. The overall crude prevalence of seroconversion after the first (n: 7,460), second (n: 13,181), and third (n: 909, all population were transplant patients with mRNA vaccine administration) dose administration was 26.17% (95% CI: 19.01%, 33.99%, I2= 97.1%), 57.11% (95% CI: 49.22%, 64.83%, I2= 98.4%), and 48.65% (95% CI: 34.63%, 62.79%, I2= 94.4%). Despite the relatively same immunogenicity of mRNA and vector-based vaccines after the first dose, the mRNA vaccines induced higher immunity after the second dose. Regarding the etiologic factor, transplant patients were less likely to develop immunity after both first and second dose rather than patients with malignancy (17.0% vs 37.0% after first dose, P=0.02; 38.3% vs 72.1% after second dose, P<0.001) or autoimmune disease (17.0% vs 36.4%, P=0.04; 38.3% vs 80.2%, P<0.001). To evaluate the efficacy of the third dose, we observed an increasing trend in transplant patients after the first (17.0%), second (38.3%), and third (48.6%) dose.Conclusion: The rising pattern of seroconversion after boosting tends to be promising. In this case, more attention should be devoted to transplant patients who possess the lowest response rate.
Cost-Effectiveness of SGLT2is Versus DPP4is Among Type 2 Diabetes Patients with and Without Established Cardiovascular Disease: A Model-Based Simulation Analysis Using 10-Year Real-World Data and Systematic Review
Authors: Peng Zi-Yang , Yang Chun-Ting , Ou Huang-Tz , Kuo Shihchen
Published: December 2021

Background: We conducted a model-based economic analysis of sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl peptidase-4 inhibitors (DPP4is) in type 2 diabetes (T2D) patients with and without established cardiovascular disease (CVD) using 10-year real-world data. Methods: A Markov model was utilized to estimate healthcare costs and quality-adjusted life-years (QALYs) over a 10-year simulation time horizon from a healthcare sector perspective, with both costs and QALYs discounted at 3% annually. Model inputs were derived from analyses of Taiwan’s National Health Insurance Research Database or published studies of Taiwanese populations. The primary outcome measure was the incremental cost-effectiveness ratios (ICERs). Incorporated with our study findings, a structured systematic review was conducted to synthesize updated evidence on the cost-effectiveness of SGLT2is versus DPP4is. Results: Over 10 years, use of SGLT2is versus DPP4is yielded ICERs of $3,244 and $4,186 per QALY gained for T2D patients with and without established CVD, respectively. Results were robust across a series of sensitivity and scenario analyses, showing ICERs between $-1,074 (cost-saving) and $8,467 per QALY gained for T2D patients with established CVD and between $369 and $37,122 per QALY gained for T2D patients without established CVD. A systematic review revealed a cost-effective or even cost-saving profile of using SGLT2is for T2D treatment. Conclusions: Use of SGLT2is versus DPP4is was highly cost-effective for T2D patients regardless of patients’ CVD history in real-world clinical practice. Our results extend current evidence by demonstrating SGLT2is as an economically rational alternative over DPP4is for T2D treatment in routine care. Future research is warranted to explore heterogenous economic benefits of SGLT2is given diverse patient characteristics in clinical settings.
Proton pump inhibitors may reduce the efficacy of ribociclib and palbociclib in metastatic breast cancer patients
Authors: ESER KADİR , ÖNDER ARİF HAKAN , SEZER EMEL , ÇİL TİMUÇİN , İNAL ALİ , ÖZTÜRK BANU , ERÇOLAK VEHBİ , DUMAN BERNA BOZKURT , ÇELİK HALİL , KÖŞECİ TOLGA , KESEN OĞUZHAN
Published: December 2021

IntroductionApproximately 20-33% of all cancer patients are treated with acid reducing agents (ARAs), most commonly proton pump inhibitors (PPIs), to reduce gastro esophageal reflux disease symptoms. Palbociclib and ribociclib are weak base so their solubility depends on different pH. The solubility of palbociclib dramatically decreases to <0.5 mg/ml when pH is above 4,5 but ribociclibs’ solubility decreases when pH increases above 6,5. In the current study, we aimed to investigate the effects of concurrent PPIs on palbociclib and ribociclib efficacy in terms of progression free survival in metastatic breast cancer (mBC) patients.Patients and methodsWe enrolled hormone receptor-positive, HER2-negative mBC patients treated with endocrine treatment (Letrozole or fulvestrant) combined palbociclib or ribociclib alone or with PPI accompanying our observational study. During palbociclib/ribociclib therapy, patients should be treated with "concurrent PPIs" defined as all or more than half of treatment with palbociclib/ribociclib, if no PPI was applied, it was defined as 'no concurrent PPI', those who used PPI but less than half were excluded from the study. All data collected from real life retrospectively.ResultsOur study included 217 patients, 105 of whom received palbociclib and 112 received ribociclib treatment. Of 105 patients who received Palbociclib, 65 were on concomitant PPI therapy, 40 were not. Of the 112 patients who received ribociclib, 61 were on concomitant PPI therapy, 51 were not. In the palbociclib group, the PFS of the patients using PPI was shorter than the PFS of the patients not using (13.04 months vs. unreachable, p<0.0001). it was determined that taking PPI was an independent predictor of shortening PFS (p<0.001) in the multivariate analysis, In the ribociclib group, the PFS of the patients using PPI was shorter than the PFS of the patients not using (12.64 months vs. unreachable, p=0.003). It was determined that taking PPI was single statistically independent predictor of shortening PFS (p=0.003, univariate analysis).ConclusionsOur study demonstrated that concomitant usage of PPIs was associated with shorter PFS in mBC treated with both ribociclib and especially palbociclib. If it needs to be used, PPI selection should be made carefully and low-strength PPI or other ARAs (eg H2 antagonists, antacids) should be preferred.
Panel Data Modelling for Indian Food Grain Production
Authors: ARUNACHALAM RAJARATHINAM , S Subh S , Madhaiyan Ramji
Published: December 2021

The present investigation was carried out to study the food grain production trends in different states in India based on Panel Regression Model for the period 2001-02 to 2020-2021. The results reveal that between state-to-state food grain production is highly significant the highest food grain production was registered in Uttar Pradesh followed by Punjab and Madhya Pradesh. Very lowest was registered in Kerala and Himachal Pradesh. The findings reveal that the highly significant fixed effect model was found to be suitable to study the trend and this model explains the 82% of variations in food grain production. Over all increasing in food grain production is noted.
Smallholder Dairy Farmers' Livelihoods: Opportunities and Challenges in Metta Robi Woreda, West Shewa Zone, Oromia Regional State, Ethiopia
Authors: Wami Naol Dibaba
Published: December 2021

In today's world, small-scale dairy farming has become commonplace. Farmers in Ethiopia, particularly in rural areas, have used it to supplement their income and ensure food security. This study aimed to assess the opportunities and challenges for the livelihoods of smallholder dairy farmers in Metta Robi woreda. A mixed research method was applied, with descriptive and cross-sectional research designs. A total of 372 SDFs (households) who performed dairy farming in the research area were selected using a systematic sampling technique. In addition, three kebeles in Metta Robi woreda were randomly picked from a total of 23 kebeles. The questionnaire was used to obtain quantitative data, while in-depth interviews, key informant interviews, and personal observation were employed to collect qualitative data. The quantitative data were analyzed using descriptive and inferential statistics, which were performed using SPSS Version 21. On the other hand, the qualitative data were transcribed and analyzed thematically. The findings showed that households in the study area engaged in a variety of livelihood activities. For more than half of the sampled households, on-farm activities are their primary source of income. The data also revealed that the study area's opportunities included appropriate environmental conditions, availability of land and water, market and road, social networks, access to information, crop residue availability, and credit service. However, land-use change, market fluctuations and inaccessibility, a lack of labor and sufficient competence, a lack of infrastructure, livestock diseases, and a scarcity of feed and water were mentioned as issues that affected SDFs' livelihoods. It was suggested that the government pay special attention to the challenges that affect SDFs' livelihoods in general and the study area in particular.
Platelet generation from circulating megakaryocytes is triggered in the lung vasculature
Authors: Zhao Xiaojuan , Alibhai Dominic , Walsh Tony , Tarassova Nathalie , Birol Semra , Williams Christopher , Neil Chris , Aitken Elizabeth , Waller Amie , Ballester-Beltran Jose , Gunning Peter , Hardeman Edna , Agbani Ejaife , Hers Ingeborg , Ghevaert Cedric , Poole Alastair
Published: December 2021

Platelets are small anucleate blood cells1,2 with critical roles in haemostasis, thrombosis, inflammation, vascularization, innate immunity and tissue regeneration3,4. In vitro-derived platelets, as an alternative to native platelets, are attractive for fundamental research because of their rapid genetic tractability, as vectors for drug and genetic component delivery5 and in clinical platelet transfusion. At present, however, their very low production rate, and poor agonist responsiveness, are major obstacles. Platelets are formed by fragmentation from mature polyploid megakaryocytes (MKs), their precursor cells6, although the process of their generation remains incompletely understood7,8. Bone marrow is proposed to be the main site of platelet production, however indirect evidence since the 1930s9,10 and recent direct observation11 has shown that the lung can also be a primary site of platelet biogenesis. Here we established an ex vivo mouse heart-lung model (Fig. 1a) through which we were able to perfuse murine MKs. Remarkably, we could show for the first time that MKs, despite their large size, can pass multiple times through the lung vasculature, and that this leads to the generation of very large numbers of fully functional platelets (up to 3,000 per megakaryocyte7,12). Using this system and a novel in vitro microfluidic chamber we show roles for ventilation, oxygenation and healthy pulmonary endothelial cells in platelet generation. We show that MKs undergo enucleation upon repeated passage through pulmonary vasculature before fragmentation to generate platelets, with this final process dependent on the actin regulator TPM4. This advances our understanding of platelet formation in the body and establishes a novel approach to generate large numbers of them outside the body.
ATM- and ATR-Induced Primary Ciliogenesis Promotes Cisplatin Resistance in Pancreatic Ductal Adenocarcinoma
Authors: Chao Yu-Ying , Huang Bu-Miin , Peng I-Chen , Lai Yi-Shyun , Chiu Wen-Tai , Lin Yi-Syuan , Lin Shih-Chieh , Chang Jung-Hsuan , Chen Pai-Sheng , Tsai Shaw-Jenq , Wang Chia-Yih
Published: December 2021

BackgroundPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers because of its late diagnosis and chemoresistance. Primary cilia, the cellular antennae, are observed in most human cells to maintain development and differentiation. Primary cilia are gradually lost during the progression of pancreatic cancer and are eventually absent in PDAC. However, recent study showed that primary cilia regrowth contributes to the development of diverse kinase inhibitor resistance in lung cancer. We elucidated the role of regrowth primary ciliogenesis in PDAC chemoresistance and uncovered the underlying molecular mechanism.ResultsWe showed that cisplatin-resistant PDAC regrew primary cilia. Additionally, genetic or pharmacological disruption of primary cilia sensitized PDAC to cisplatin treatment. Mechanistically, ataxia telangiectasia mutated (ATM) and ATM and RAD3-related (ATR), tumor suppressors that initiate DNA damage responses, promoted the excessive formation of centriolar satellites (EFoCS) and autophagy activation. Disruption of EFoCS and autophagy inhibited primary ciliogenesis, sensitizing PDAC cells to cisplatin treatment. ConclusionsCollectively, our findings revealed an unexpected interplay among the DNA damage response, primary cilia, and chemoresistance in PDAC and deciphered the molecular mechanism by which ATM/ATR-mediated EFoCS and autophagy cooperatively regulate primary ciliogenesis.
Tree-based Mulches Influence Soil Properties and Plant Growth
Authors: Maggard Adam O. , Will Rodney E. , Hennessey Thomas C. , McKinley Craig R. , Cole Janet C.
Published: December 2021

The objective of this research was to determine the response of soil properties and plant growth to the application of various tree-based mulches and provide information specifically regarding attributes of eastern redcedar mulch (Juniperus virginiana). Eastern redcedar mulch, cypress mulch (Taxodium distichum), pine bark nuggets [southern yellow pine (Pinus sp.)], pine mulch (southern yellow pine), hardwood mulch [maple (Acer sp.), oak (Quercus sp.)], red-dyed mulch [maple, poplar (Populus sp.)], and grand eucalyptus mulch (Eucalyptus grandis), as well as two nonmulched controls (with and without chemical weed control) were tested. Volumetric soil moisture, soil nutrients, soil temperature, weed growth, and growth and survival of planted annuals and trees were measured. Compared with nonmulched controls, mulch treatments generally increased growth of annuals and trees and decreased weed growth, but few differences in measured variables were noted among mulch types. Mulched plots had greater volumetric soil moisture than nonmulched plots during extended periods without rainfall. Mulched plots had more moderate diurnal soil temperatures than nonmulched control plots. Soil pH and soil potassium increased with hardwood mulch during the 2 years of the study. These results indicate tree-based mulch benefits plant growth and survival by maintaining greater soil moisture, decreasing competition from weeds, and moderating soil temperatures compared with not using mulch. Eastern redcedar mulch provides similar benefits as other common wood mulches and is a viable forest product.
Pendekatan Kolaboratif dalam Menangani Konflik Spasial Kawasan Pesisir di Pantai Selatan Yogyakarta
Authors: Darmawan Iwan , Ikaputra
Published: December 2021

Title: A Collaborative Approach to Handling Coastal Spatial Conflicts in Yogyakarta Southern Coast
 
Yogyakarta's southern coastal ecosystem is facing increasing impacts from fisheries, aquaculture, tourism, energy production, shipping, pollution, climate change and other stressors. This paper discusses the importance of collaborative planning, more than community-based in coastal tourism areas as well as mangrove forest conservation areas, as well as environmental stressors in the form of shrimp ponds. The purpose of this paper is to analyze the understanding of the type of planning approach that is most appropriate, namely collaborative in areas that have spatial conflicts. The method used in this paper is a literature study which describes the theory, findings, and other research materials obtained from reference material to be used as a research basis by compiling a clear framework from the formulation of the problem to be studied. coupled with field observations. The author then provides a review, summary, and dialogue about the theory which is then used to build a relevant theoretical framework. Literature references used are related to collaborative planning and coastal tourism. Based on the discussion that has been done, it can be concluded that to overcome spatial conflicts in the southern coastal tourism area of ??Yogyakarta, this type of planning with a collaborative approach is the most appropriate to be applied wherein the process involves stakeholders with the ultimate goal of a collective agreement for all parties and with a sustainable perspective.
PLASTIA INGUINAL, ABORDAJE LAPAROSCOPICO VS ABORDAJE ABIERTO: EXPERIENCIA EN CENTRO MEDICO NAVAL
Authors:   Departamento De Cirugia General, Centro Medico Naval, Ciudad De Mexico, Mexico., Alejandro Gomez-Chavez M. , Simon-Mendoza Alex ,   Departamento De Cirugia General, Centro Medico Naval, Ciudad De Mexico, Mexico.
Published: December 2021

Vivimos una epoca donde la cirugia laparoscopica vino a revolucionar el abordaje de los diferentes procedimientos quirÃºrgicos, incluyendo la reparacion de hernias inguinales. En Centro Medico Naval se realizan dichas cirugias desde 2016, por lo que es fundamental un analis de la evolucion clinica de los pacientes comparada con el estandar de oro que es la tecnica de Lichtenstein. Objetivo: Comparar los resultados clinicos de pacientes con hernias inguinales operados por laparoscopia y cirugia abierta atendidos en Centro Medico Naval. Material y metodos: Se analizaron 91 expedientes electronicos de pacientes con diagnostico de henia inguinal los cuales fueron intervenidos quirÃºrgicamente. Se realizo el analisis descriptivo e inferencial con el fin de comparar la plastia inguinal laparascopica versus la tecnica de Lichtenstein. Resultados: No se encontraron diferencias estadisticamente significativas para las variables de tiempo de estancia intrahospitalaria o complicaciones. Sin embargo, el tiempo de recuperacion para la incorporacion del paciente a la vida laboral fue menor para el grupo de pacientes operados por cirugia laparoscopica con un promedio de 7 dias menor. Conclusiones: En Centro Medico Naval, la cirugia laparoscopica ofrece una alternativa para el tratamiento de hernias inguinales, incorporando a los pacientes a su vida laboral en un tiempo menor, sin diferencia en las complicaciones.
A CASE REPORT ON MULTISYSTEMIC INFLAMMATORY SYNDROME- CHILDREN HOW THE DIAGNOSIS AND TREATMENT COULD BE CHALLENGING
Authors:   Registrar in Emergency Medicine., Basnayake S.U. , Dissanayakege T.G ,   Senior Registrar in Anaesthesia and Intensive Care.
Published: December 2021

Although COVID 19 infections in children are generally mild and non-fatal, there is increasing recognition of a multisystem inflammatory syndrome in children (MIS-C) associated with COVID-19, leading to severe illness and long-term sequelae. Even though there is some evidence that the MIS-C is a post-viral immunological reaction to COVID-19, understanding of the immune response induced by SARS-CoV-2 remains unclear.Various local and international guidelines are being widely practiced in the diagnosis and management of patients with MIS-C. A case report of a young child who was diagnosed and managed as MIS-C is discussed here. The diagnostic challenges with the available case definitions and currently accepted treatment options are elaborated herein.
ORAL CANCER AWARENESS AMONG NON-MEDICAL PROFESSIONALS - A CROSS SECTIONAL STUDY IN LADAKH
Authors:   Post Graduate Student, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu., Hussain Mohd , Anjum Rubeena ,   Professor & Head, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu., Kaur Mandeep ,   AssistantProfessor, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu., Khajuria Nidhi ,   Lecturer, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu., Bhat Nitish ,   Tutor, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu., Bhardwaj Ashanka ,   Tutor, Department of Oral & Maxillofacial Pathology & Oral Microbiology, IGGDC, Jammu.
Published: December 2021

Introduction:Oral Cancer is the fifthâ€‘most common cancer and is the cause of 130,000 deaths worldwide annually. It is a global health problem with an increasing incidence and mortality rate and also has one of the lowest survival rates.Therefore, the aim of this study is to assess the awareness about Oral Cancer among non-medicalprofessionals in Ladakh. Methodology:A questionnaire-based survey was conducted over a period ofsixmonth among the different areas of Ladakh to assess the knowledge and awareness about Oral Cancer among non-medical professionals in Ladakh. A questionnaire containing 20 questions pertaining to awareness, signs, symptoms and risk factors of Oral Cancer was submitted to the participants. Results:Participants who completed the questionnaire had a poor understanding of Oral Cancer, particularly with regard to etiology, signs, symptoms & risk factors. Conclusion:Overall, the awareness about Oral Cancer among the non-medical professionalsin Ladakh was not satisfactory pointing to the need of mass awareness and dissemination of information about Oral Cancer and its risk factors.
GCMS AND TLC ANALYSIS OF ETHANOLIC EXTRACT OF SEED MOMORDICA CHARANTIA
Authors:   Professor & Assistant Professor, Department of Pharmacognosy, C L BaidMetha College of Pharmacy, Chennai., Purushoth Prabhu T. , Naichyar Shanthini ,   Professor & Assistant Professor, Department of Pharmacognosy, C L BaidMetha College of Pharmacy, Chennai., a Sheela ,   Professor & Assistant Professor, Department of Pharmacognosy, C L BaidMetha College of Pharmacy, Chennai., b Kavitha ,   Professor & Assistant Professor, Department of Pharmacognosy, C L BaidMetha College of Pharmacy, Chennai., N Kabilan ,   Professor, Department of Siddha, The Tamil Nadu Dr M G r Medical University, Chennai., V Ravichandran ,   Principal & Professor, P S V College of Pharmaceutical Science and Research, Krishnagiri.
Published: December 2021

To perform the TLC and GCMS analysis of ethanolic extract of seed Momordica charantia. The seeds ofMomardicacharantia was extracted with ethanol and tested for TLC and GCMS by standard procedure as per the guidelines of WHO.The phytochemical and TLC studies showed the presence of alkaloids, cardiac glycosides, phenols, steroids, terpenoids and proteins.The GCMS analysis of seed Momardicacharantiashowed five major compounds were found to be n-hexadeconic acid, 9,12-Octadecadinoic acid,Octadecanoic acid,Hexadecanoic acid-2-hydroxy-1-hydroxy methyl ethyl ester and Gamma-sitosterol.The Therapeutic activity may be due to the major compounds identified by GCMS and further have to be evaluated.Mostly cucurbitaceae plant possesses the highest nutritive value and also a good source of carbohydrates, proteins, fibers, vitamins, and minerals. Fruits are composed of sufficient of water,protein and lipids respectively.In addition to this MC seeds can represent a good source of lipids, such as polyunsaturated fatty acids and they are among the few foods containing conjugated linolenic acid, being as eleostearic acid. The essential oil, obtained from drought seeds, contains sesquiterpenes, phenylpropanoids and monoterpenes. Other bioactive compounds, such as tocopherols and polyphenols have been reported in general. The pericarp, the aril, the stem and the leaves of the plant are also a good source of phenolic compounds, which can be useful to protect from oxidative damage by acting directly on reactive oxygen species and to induce endogenous defense systems.
PERICARDIAL PUNCTURE: WHEN AND HOW?
Authors:   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat., Seghrouchni A. ,   Faculty of Medicine and Pharmacy of Fes, University of Sidi Mohamed Ben Abdellah Fes., Mokhlis H. ,   Cardiology Department, Mohammed V Military Training Hospital - Rabat., Manir S. El ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat., Mounir R. ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat., Eden Ali A. ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat., Atmani N. ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat.,   Faculty of Medicine and Pharmacy of Fes, University of Sidi Mohamed Ben Abdellah Fes., Moutakiallah Y. ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat., EL Bekkali Y. ,   Cardiovascular Surgery Department, Mohammed V Military Training Hospital - Rabat.
Published: December 2021

Pericardial effusion is a very common condition, due to the accumulation of fluid in the pericardial cavity (the impact depends on the volume, rate of accumulation and elasticity of the pericardium), it results in a: 1. Increased intrapericardial pressure. 2. Increase in intracardiac pressure 3. Decrease in ventricular filling 4. Decrease in ejection volume 5. Decrease in cardiac output The etiologies of effusions are diverse. Tamponade requires emergency decompression of the pericardium to achieve hemodynamic stabilization. Two techniques are possible, either percutaneous puncture with or without ultrasound guidance, or surgical drainage. The choice of drainage method depends on the medical-surgical teams, their experience with each method and the etiology.
AN ANALYSIS OF NON PERFORMING ASSETS OF INDIAN SCHEDULED COMMERCIAL BANKS
Authors:   PhD Research Scholar, Dept. of Economics, Sambalpur University, Jyoti Vihar, Burla., Mishra Bhabani
Published: December 2021

Non-performing Asset breaks the recycling procedure of deposit and investment as it does not generate substantial income and blocks the cash flow. The motive of the paper is to conduct comparative analysis among Gross NPA, Net NPA, and Net Profit by adopting correlation, ANOVA, the average for selected bank groups which are analyzed in MS-EXCEL and SPSS. The aggregate data of 16 years from 2004-05 to 2019-20 is taken from the RBI website. Public Sector banks acquire more GNPA and NNPA and less Net Profit as compared to other two due to various reasons explained in this paper. Pearson correlation in SPSS shows that there is strongly negative and significant correlation between net profit and GNPA of public sector bank group which reflects that rising bad assets can reduce the banksâ€™ profitability. But in case of foreign banks group, a strong but positive association between net profit and GNPA is observed. The Private bank group shows no significant association between these two variables. ANOVA test result shows there is a significant difference in the movement of GNPAs and NNPAs (in amounts) for different groups of banks during the study period. But in the case of Net profit, no significant difference was observed for these bank groups.
CORPORATE SOCIAL RESPONSIBILITY PRACTICES AMONG BUSINESS ORGANISATIONS FOR CHILDREN WITH LEARNING DIFFICULTIES AND OTHER DISABILITIES
Authors:   Department of Community Education and Disability Studies, Panjab University, Chandigarh, India., Kashyap Tanvi , Sharma Anuradha ,   Department of Community Education and Disability Studies, Panjab University, Chandigarh, India.
Published: December 2021

The concept of corporate social responsibility has been evolving over the years, as many business firms have started to understand its importance. To study the corporate social responsibility practices of business organisations for children with learning difficulties and other disabilities, we collected data from fourteen eminent business organisations and analysed their understanding and necessity of social responsibility practices by business organisations in the present times, with special emphasis on social responsibility practices for children with learning difficulties and other disabilities. Results showed that even though 83.3% of the business organisations have initiated corporate social responsibility practices in the field of education, only 7.14% of the total sample initiated corporate social responsibility practices for children with learning difficulties and other disabilities.
MANAGEMENT RECOMMENDATIONS OF WILD BOAR IN SUB-TROPICAL CHIR PINE FOREST IN SIRAN FOREST DIVISION, TANGLAI RESERVE FOREST, DISTRICT MANSEHRA, KHYBER PAKHTUNKHWA
Authors:   Pakistan Forest Institute Peshawar, 25130., Zamir Ahmed , Muhammad Umrani Arz ,   Pakistan Forest Institute Peshawar, 25130., Khan Tariq ,   Pakistan Forest Institute Peshawar, 25130., Ahmed Jan Shabbir ,   Pakistan Forest Institute Peshawar, 25130., a Bashirullah ,   Pakistan Forest Institute Peshawar, 25130.
Published: December 2021

The current study was conducted in May & June 2021 in Tanglai State Forest which is a Sub-Tropical Chir Pine Forest Type, the key species are: Common Leopard (Pathera pardus), Wild Boar (Sus scrofa), Jackals (Canis aureus), Rhesus Monkey (Macaca Mulatta), Kalij Pheasant (Lophura leucomelanos), Flying Squirrels (Pteromyini). In KPK, Wild Boar is found mostly in the west of Indus around Peshawar, Mardan Bannu, D.I Khan etc. In this paper it is recommended that the presence of Wild Boar and the way they may affect their habitat should be monitored because its population multiplies so fastly having high reproduction potential i.e. reaching sexual maturity as early as six (06) months of age, therefore, it is required to be managed in the habitats, the aim of such control should be to bring Wild Boar population into balance on particularly sensitive sites or in response to disease control. Moreover, this work is also aimed to suggest wild boar management to the authorized department, these approaches of management will be profitable to mitigate its adverse damages to the agricultural crops, forest crops, human beings, livestock i.e. wildlife conflicts.
Lugares de memoria, lugares de silencio: la esclavitud atlántica en museos españoles y cubanos desde una perspectiva comparada internacional
Authors: Schmieder Ulrike
Published: December 2021

El artículo hace referencia a los resultados de un proyecto sobre memorias de la esclavitud atlántica. Compara los museos analizados en España y Cuba con respecto a la visualización y los discursos explicativos sobre el pasado esclavista, la imagen presentada de los esclavistas y los esclavizados (Museo de América en Madrid, Museo de Historia de Cataluña, Museo Marítimo, ambos en Barcelona; la Casa de África en La Habana, el Museo de la Ruta del Esclavo en Matanzas, la Sala Museo en Álava/ Méjico) con museos del Reino Unido y Francia. El análisis de la museología fue acompañado de entrevistas con actores de la memoria. El estudio constata la falta de voz de los esclavizados en todos los museos españoles y cubanos excepto en el pequeño museo local de Álava/ Méjico. En los museos españoles persisten imágenes visualizadas y conceptos verbales racistas sobre los esclavizados, que son mostrados como mercancías y seres humanos inferiores, y no como rebeldes y agentes de su propia historia. Además, los perpetradores y beneficiarios del tráfico de africanos y de la esclavitud no aparecen en la museología, la esclavización se presenta como un acontecimiento natural. El texto argumenta sobre las posibles causas de esta diferencia frente a los museos ingleses y franceses, en los que las exposiciones hacen referencia también a la resistencia de los esclavizados y en algunos casos citan fuentes que reflejan su propia perspectiva.
Comunicar e interagir em novos espaços: o uso das mídias sociais no Sistema de Bibliotecas da UFRN
Authors: Muniz Euzebia Maria de Pontes Targino
Published: December 2021

O presente estudo discorre acerca da prática de comunicação nas bibliotecas a partir da apropriação dos recursos da web 2.0, em especial das mídias sociais, estabelecendo a partir dos aspectos da midiatização novos cenários de comunicação em seus ambientes.
Mapeamento de competências para a implantação e gestão de repositórios institucionais
Authors: Barbosa Everton Rodrigues
Published: December 2021

Aborda o mapemanto de competências para a criação e manutenção de repositórios institucionais, a partir da visão do gestor do Repositório Institucional da Universidade Federal do Rio Grande do Norte. Apresenta um panorama sobre a criação de RIs no Brasil, e as competências gerais exigidas ao profissional bibliotecário frente a promoção de produtos e serviços de informação em plataformas digitais. Utiliza pesquisa bibliográfica. Analisa qualitativamente os dados de acordo com os pesos atribuídos às habilidades identificadas. Conclui que as competências consideradas de maior relevância se relacionam com a visão e estratégia organizacional. Esse aspecto denota que o profissional deve primeiramente conhecer a visão e missão da instituição, bem como políticas e normas internas, para implantar e desenvolver o RI local.
A biblioteca escolar sob o olhar da comunidade
Authors: Pereira Ismael Soares
Published: December 2021

A biblioteca escolar é vista como um ambiente fundamental na formação educacional básica dos estudantes. Sem profissionais qualificados para gerenciar esse espaço não é possível cumprir satisfatoriamente o seu papel de apoio sociocultural, recreativo, educativo e didático-pedagógico. Pretende-se com esta pesquisa mostrar a visão dos alunos do Ensino Fundamental II e o posicionamento dos professores e da gestora a respeito da necessidade de implantação de uma biblioteca na Escola Estadual de Ensino Fundamental Henrique Dias, situada na cidade de João Pessoa, bem como sua gestão por um bibliotecário. Para o desenvolvimento desse trabalho, realizou-se primeiramente um levantamento bibliográfico sobre o tema estudado e em seguida partiu-se para a pesquisa de campo, onde foram aplicados questionários a 35 (trinta e cinco) alunos do 6º ao 9º ano, a cinco professores e a uma gestora. Esta pesquisa é de natureza qualitativa e de nível descritivo. Conclui-se que sob a ótica da comunidade estudada, na referida escola é necessária a implantação de uma biblioteca bem estruturada e gerenciada por profissionais qualificados para esse fim, pois só dessa forma o processo de ensino-aprendizagem irá ocorrer de forma satisfatória e com qualidade.
Ética e a mediação da informação
Authors: Almeida Rita de Cassia , Silva Eliane Ferreira da
Published: December 2021

Delineia conceitos interrelacionados da ética profissional e a gestão da informação, bem como as implicações na atuação do bibliotecário perante o panorama social contemporâneo. Objetiva compreender as transformações decorrentes da Sociedade do Conhecimento e refletir sobre a atuação ética dos profissionais de informação neste cenário. Trata-se de revisão bibliográfica selecionada em materiais impressos e eletrônicos na área de Ciência da Informação e pertinentes à temática, tendo como descritores “ética” e “mediação da informação”. Acrescida à relevância de discussões sobre a contingência de mudanças atitudinais do bibliotecário do século XXI, evidencia-se a lacuna de publicações científicas que abordem pesquisas de campo, diligenciando investigações complementares.
Cartas de Zila: fragmentos de sua autobiografia
Authors: Marques Tércia Maria Souza de Moura , Menezes Margareth Régia de Lara
Published: December 2021

Uma pequena biografia da poeta e bibliotecária Zila da Costa Mamede, escrita a partir de uma vasta coleção de manuscritos, documentos e cartas, doados a Biblioteca Central da Universidade Federal do Rio Grande do Norte. Desse modo, os pequenos fragmentos transcritos neste ensaio mostra Zila em sua essência.
Qualidade do serviço de bibliotecas universitárias: um estudo comparativo das percepções de usuários em contextos público e privado
Authors: Nascimento Maria Socorro
Published: December 2021

Este é um estudo comparativo que tem como objetivo analisar as expectativas e percepções do serviço de bibliotecas universitárias recebidos por alunos de graduação em contextos público e privado. A pesquisa teve um caráter exploratório/descritivo e trata de um estudo de caso com uma abordagem quantitativa. O universo da pesquisa foi constituído por 3.497 alunos dos cursos de Administração e Direito, turno diurno e noturno de uma IES pública e privada. As amostras foram estratificadas considerando cada IES, curso e turno, resultando em 1090 alunos entrevistados. O instrumento de coleta de dados foi um questionário estruturado com perguntas fechadas, definido a partir de um conjunto de 32 atributos do serviço oferecido por bibliotecas coletados a partir de estudos empíricos nacionais e internacionais, e que foram validados e consolidados por professores, alunos e bibliotecários das duas instituições. Os resultados apontaram diferentes expectativas dos alunos por instituição, curso e turno. No entanto, foi revelado, nos grupos de importância para cada IES e curso, elementos comuns, embora não sejam colocados na mesma ordem de prioridade. No grupo dos mais importantes, os atributos comuns para as duas IES foram: horário de funcionamento, organização de estantes e espaço, higienização e limpeza, acesso à base de dados via internet e solicitar compra de livros. Para os alunos dessas instituições, os serviços recebidos estão abaixo de suas expectativas. As matrizes de importância e desempenho apresentam oportunidades de melhorias, por curso, turno e IES. Atributos como serviço de normalização/catalogação e solicitar compra de livros devem melhorar, sem dúvida, na IES privada; para a IES pública, atualização do acervo, acesso à  base de dados via internet  e solicitar compra de livros. Os resultados apresentados pelas matrizes podem auxiliar os gestores das bibliotecas das duas instituições a gerenciar a qualidade dos seus serviços com base na relação importância x desempenho.
Repositorio digital da Escola Superior de Magistratura do Estado do Maranhao: proposta de implantação
Authors: Santos Joseane Cantanhede dos
Published: December 2021

No âmbito da produção intelectual, preservação e compartilhamento de saberes, as bibliotecas modificaram categoricamente a forma de organizar, recuperar e disseminar suas informações para além do espaço físico das instituições a que estão veiculadas. O estudo teve como objetivo principal propor a implantação do repositório digital da Escola Superior da Magistratura do Estado do Maranhão - ESMAM, fomentando a produção intelectual dos magistrados e servidores do Poder Judiciário maranhense. A proposta apresentada resulta do desenho da pesquisa traçado no levantamento de textos sobre a relevância do repositório institucional em ambiente acadêmico e não acadêmico, a identificação e análise de diretrizes para a criação de repositórios, gestão de dados técnicos e conceituais, além de indicações quanto ao uso das licenças Creative Commons para a expansão de fontes de informação. Dessa forma, sugere-se o uso do Dspace, um software livre desenvolvido pelo Massachusetts Institute of Technology e disponibilizado gratuitamente pelo Instituto Brasileiro de Informação em Ciência e Tecnologia - IBICT, para a criação de repositórios digitais. Conclui-se que essa proposta possibilitará a ampliação de 50% da produção intelectual dos magistrados e servidores; redução de 60% do custo com impressão de material instrutivo, manuais, cartilhas, apostilas, dentre outros impressos informativos e/ou educativos. Além disso, contribuirá para a preservação da memória institucional, por meio das diversas áreas de conhecimento que dialogam no âmbito do Poder Judiciário e a sociedade maranhense.
Usabilidade da Interface do Sistema Eletrônico de Editoração de Revistas um estudo da revista BiblioCanto da UFRN
Authors: Maia Maria Aniolly Queiroz
Published: December 2021

As revistas científicas eletrônicas correspondem a canais de publicação e divulgação da informação científica. Por meio delas, os usuários podem disseminar seus estudos, assim como desenvolver novas pesquisas. Um dos sistemas utilizados para criação e gestão de periódicos eletrônicos é o Sistema Eletrônico de Editoração de Revistas (SEER), utilizado na construção de portais de periódicos, assim como na criação de revistas isoladamente. Nesse sentido, acredita-se que os sistemas de gestão e criação de revistas científicas eletrônicas devem ser desenvolvidos (interna e externamente) de acordo com as necessidades dos seus usuários. No caso do desenvolvimento interno, alguns desses processos se referem ao cadastro de autor e à submissão de artigos, que, por sua vez, são tarefas relevantes no processo editorial. Assim, o estudo proposto, de temática Usabilidade de periódicos científicos, objetiva analisar a usabilidade do processo de cadastro de autor e de submissão de artigos no SEER por meio da revista BiblioCanto, que integra o Portal de Periódicos Eletrônicos da Universidade Federal do Rio Grande do Norte (UFRN). Para a efetivação da pesquisa, foram utilizadas duas técnicas de avaliação: o Teste de Usabilidade com um total de vinte participantes e a Avaliação Cooperativa, com o mesmo número de participantes, divididos em quatro categorias consideradas público alvo da referida revista, a saber: discentes de graduação, discentes de pós-graduação, docentes e bibliotecários. Os resultados apontaram que os dois processos analisados (cadastro de autor e submissão de artigos) necessitam de melhorias. Em se tratando do processo de cadastro, destacam-se as seguintes necessidades: sinalização do ambiente de realização de cadastro; descrição e exclusão de informações solicitadas no formulário para cadastramento. No processo de submissão de artigos, enfatizam-se melhorias dos aspectos: início dos passos para submissão, sinalização de campos obrigatórios, descrição concisa das etapas, minimização e revisão das etapas. Por fim, acredita-se, que de uma forma geral, o SEER atende parcialmente às necessidades dos seus usuários no tocante à usabilidade do referido software.
Genealogia para um lugar
Authors: Klein Vinicius Pellizzaro
Published: December 2021

Trata-se de um breve ensaio sobre a formação de um pesquisador e sua relação com os campos de saber acionados na sua atuação que a partir desta interação definem seu lugar de atuação.
Biblioteca Digital de Monografia da Universidade Federal do Rio Grande do Norte: análise do embargo das monografias na área da saúde
Authors: Medeiros Joyanne de Souza
Published: December 2021

Investiga o embargo dos trabalhos de conclusão de curso na Biblioteca Digital de Monografia nos cursos de Enfermagem, Fisioterapia e Nutrição nos campus Natal e Santa Cruz. Embargo de publicação é uma restrição de acesso a uma obra por um tempo determinado. A cultura organizacional define regras, normas e padrões seguidos numa organização, definindo o que é permitido ou não para um grupo.  Apresenta o modelo de Wilson de Necessidade e Procura e por informação, pensando no indivíduo e a possibilidade do contexto influenciar o comportamento de uma pessoa. Acredita assim que o embargo pode ser visualizado a partir desse cenário. O método de pesquisa utilizado foi estudo de caso nos cursos de Enfermagem, Fisioterapia e Nutrição das cidades de Natal e Santa Cruz, em que o Setor de Repositórios Digitais disponibilizou os dados. Por fim, percebeu-se que o embargo reflete mais no contexto da Facisa.
Estudo bibliométrico sobre pesquisas relacionadas ao Portal de Periódicos da CAPES
Authors: Silva Lopes Ana Cristina
Published: December 2021

Com o grande número de publicações científicas disseminadas no mundo, o Portal de Periódicos Capes configura-se como ferramenta de busca e recuperação de informação fundamental para as pesquisas científicas, construção e disseminação do conhecimento. Diante disto, esta pesquisa propõe um estudo bibliométrico à cerca dos artigos publicados na área de Ciência da Informação em revistas classificadas pelo sistema WebQualis nos estratos A1 e A2, que tiveram o Portal como objeto de análise, no intuito de identificar sobre quais aspectos o Portal foi investigado, de acordo com as variáreis: ano de publicação, autoria (formação e instituição de origem) e abordagem temática.
Produção científica e produtivismo acadêmico no processo avaliativo da pós-graduação brasileira
Authors: Lima Juliane Medeiros de , Vanti Nadia
Published: December 2021

O presente estudo tem por objetivo refletir sobre a produção científica e o produtivismo acadêmico no processo avaliativo da pós-graduação brasileira. O método de abordagem utilizado para a realização da pesquisa foi o método dedutivo, pois se trata de uma pesquisa bibliográfica. Como resultados, o estudo discute a relevância da comunicação científica para a sociedade da informação, o desenvolvimento da pesquisa científica e dos periódicos científicos e a forma atual de avaliação da produção científica no Brasil. Por fim, o estudo conclui que é necessária uma revisão e adequação de critérios avaliativos que distingam produção científica e produtivismo, visando minimizar injustiças e contribuir para o crescimento científico e tecnológico do país.