bluuebunny/crossref_metadata_2025 huggingface dataset:
A Mixed Methods Study Exploring Barriers and Enablers to Physical Activity Participation Among Women in Coastal Communities.
Authors: Ominyi Jude , Clifton Andrew
Published: November 2024

Background: Physical inactivity is a critical global health issue that contributes to increased morbidity and mortality rates worldwide. Regular physical activity (PA) benefits both physical and mental health, with particular importance for women, who face increased risks for chronic conditions associated with inactivity. This study examines barriers to and enablers of PA participation among women in coastal communities in East England, a population particularly affected by socioeconomic, environmental, and logistical challenges to maintaining active lifestyles.
Methods: This study employed a mixed-methods convergent parallel design, integrating qualitative and quantitative data collected from 112 adult women recruited through local PA and weight loss programmes. Data collection utilised the International Physical Activity Questionnaire (IPAQ) and the Exercise Benefits and Barriers Scale (EBBS), alongside scenario-based and open-ended qualitative questions. The quantitative data were analysed via descriptive statistics and logistic regression in SPSS, whereas the thematic analysis of the qualitative data was conducted in NVivo.
Results: Quantitative findings indicate that healthcare professionals (40%) are the primary source of PA information, with health benefits (36%) being the main motivator. Key barriers include family responsibilities (45%), low self-confidence (31%), and limited access to facilities (27%). Logistic regression revealed that women with family caregiving roles and existing health conditions were less likely to engage in PA. Qualitative data further highlight psychological and environmental barriers, alongside motivators such as medical advice, social support, and personal goals, which significantly impact PA participation.
Conclusions: Women in coastal communities face unique socioenvironmental and psychological barriers to PA engagement. Effective interventions may need to incorporate multilevel, community-based approaches that address these specific challenges. This study highlights the potential for tailored interventions that leverage health advice, support networks, and culturally relevant programming to foster sustainable PA engagement among women in similar settings.
Ruptured tubal stump ectopic pregnancy after previous ipsilateral salpingectomy:a case report and literature review.
Authors: Kibret Asfaw
Published: November 2024

Ectopic pregnancy is life threatening condition occuring due to the implantation of fertilized ovum out side the uterine endometrial cavity. Its common site is fallopian tube. Stump ectopic pregnancy after previous salpingectomy on ipsilateral tube is the rare occurrence. We present a 26yrs old female patient with tubal stump ectopic pregnancy who was undergone salpingectomy on ipsilateral tube one year back. This is the first report from ethiopia.
Formelle und informelle Partizipation von Studierenden für ein gelebtes Qualitätsmanagement
Authors: Bucher Adrian , Duvoid Luc
Published: November 2024

Dieser Entwicklungsbeitrag versteht sich als Ausgangspunkt für die Auseinandersetzung mit einer wirkungsvollen studentischen Partizipation im Kontext des Qualitätsmanagements: Werden Voraussetzungen und Strukturen geschaffen, in denen sich Studierende als wesentlicher, essenzieller Teil des Qualitätsmanagements wahrzunehmen beginnen, entstehen formelle und informelle Kontakte, welche zur Weiterentwicklung der Organisation einen wesentlichen Beitrag leisten. Nach einer kurzen Bestandesaufnahme und der Vorstellung der studentischen Partizipation im Kontext des Qualitätsmanagements wird deren ‚Herzstück‘ in Form von drei Gelingensbedingungen und einer abschließenden Hypothese dargelegt.
Where are Emotions in Text?
Authors: Troiano Enrica
Published: November 2024

Natural language processing (NLP) boasts a vibrant tradition of emotion studies, unified by the aim of developing systems that generate and recognize emotions in language. The computational approximation of these two capabilities, however, still faces fundamental challenges, as there is no consensus on how emotions should be processed, particularly in text: application-driven works often lose sight of foundational theories that describe how humans communicate what they feel, resulting in conflicting premises about the type of data best suited for modeling and whether this modeling should focus on textual meaning or style. My thesis fills in these theoretical gaps that hinder the creation of emotion-aware systems, demonstrating that a trans-disciplinary approach to emotions, which accounts for their extra-linguistic characteristics, has the potential to improve their computational processing.
I investigate the human ability to detect emotions in written productions, and explore the linguistic dimensions that contribute to the emergence of emotions through text. In doing so, I clarify the possibilities and limits of automatic emotion classifiers and generators, also providing insights into where systems should model affective information.
Extensão universitária e tecnologia grupal: refletindo a prática profissional na atenção psicossocial para transformar o modelo assistencial
Authors: SOUSA Johnatan Martins , FARINHA Marciana Gonçalves , CAIXETA Camila Cardoso , PARANAGUÁ Thatianny Tanferri de Brito , NUNES Fernanda Costa , BEZERRA Ana Lúcia Queiroz
Published: November 2024

Objetivou-se descrever reflexões de profissionais de saúde mental sobre as suas atuações em Centros de Atenção Psicossocial. Pesquisa-intervenção qualitativa realizada com 30 profissionais de dois Centros de Atenção Psicossocial da região central do Brasil, aprovada pelo comitê de ética Parecer n° 4.298.136. Para a coleta de dados foram implementadas quatro oficinas e para refletir sobre o componente do Método Clínico Centrado na Pessoa - fortalecendo a relação entre a pessoa e o médico/profissional de saúde, foi empregada técnica de aquecimento com as questões: Como você gostaria de ser atendido no serviço de saúde mental?; Como você costuma atender os usuários do serviço? Gostaria de ser atendido por si mesmo? Os dados foram submetidos à análise de conteúdo temática. Emergiram três categorias que revelam reflexões sobre a assistência à saúde mental: 1. Invertendo os papéis; 2. Autopercepção da atuação profissional; 3. Entre o querer e o não querer.
CONTAMINATED SPEECH AS A MARKER OF COMMUNICATION FAILURE IN DIALOGUES OF JACK LONDON’S WORKS
Authors:   St. Petersburg State University, Kunitsin Andrey V.
Published: November 2024

This article is concerned with the study of the role of contaminated speech in revealing the relationship between the characters of a work of fiction. The material used for the study is the works of Jack London — “Martin Eden” (1909) and “The Scarlet Plague” (1910). The concept of norm was introduced as the main premise for the study, which was interpreted differently by the participants of the dialogue. In the course of the research, two communicative models associated with different levels of education of the communicants were identified — the dialogue-argument and the dialogue-explanation. When analyzing the examples, the method of binary opposition was used, associated with the opposition of contaminated and non-contaminated speech as marked and unmarked members of the opposition.
THE SUBTLETIES OF TRANSLATING PUBLIC POLITICAL SPEECH: ON THE EXAMPLE OF SONG MEILING’S SPEECH
Authors:   St. Petersburg State University, Kunyashova Maya S. , Kovalevskaya Natalia V. ,   St. Petersburg State University
Published: November 2024

This article examines the subtleties of translating public political discourse such as political correction and translation of non-equivalent lexical items using the example of Chinese female politician Song Meilin’s speech. The definitions of equivalent translation and political discourse are given, and ways of translating non-equivalent vocabulary are suggested.
IMPROVING THE RUSSIAN LANGUAGE TRAINING PROGRAMS FOR CHINESE STUDENTS IN THE TOURISM INDUSTRY IN ORDER TO INCREASE THE EFFECTIVENESS OF TRAINING
Authors:   St. Petersburg State University, Maslova Ludmila S. , Yan Haiou ,   St. Petersburg State University
Published: November 2024

This paper explores the ways of enhancing the Russian language training programs for Chinese students in the tourism industry to improve the effectiveness of training. With the rising number of Russian-speaking tourists visiting China and expanding economic and cultural ties between Russia and China, there is a growing need for tourism professionals who can communicate effectively in Russian. It has become particularly important to strengthen Russian language training programs for Chinese students by identifying key areas for improvement such as curriculum design, teaching methodology, cultural immersion experiences and industry collaboration. This paper aims to provide some recommendations for optimizing Russian language training programs so that students can acquire the necessary language skills and cultural competence while improving their professional skills in the tourism industry to better serve Russian-speaking tourists. The main attention is paid to curriculum design based on the task approach.
LINGUACULTURAL REPRESENTATION OF ETHNIC GROUPS IN VIDEO GAMES (A CASE STUDY OF "CYBERPUNK 2077")
Authors:   St. Petersburg State University, Chernousov Vitalii A. , Akay Oksana M. ,   St. Petersburg State University
Published: November 2024

The paper is devoted to the study of the linguistic and cultural representation of ethnic groups in video games, in particular in "Cyberpunk 2077". Factors influencing the manifestation of ethnic characteristics include the genre of the game, its scale, cultural and linguistic discourse and intercultural communication. In the game, the authors focus on the formation of a multiethnic and multicultural picture of the game world. The game is based on the "Cyberpunk 2020" tabletop role-playing game, which provides an extensive artistic and literary base. The developers pay attention to linguistic and cultural representation, striving to create a positive experience for the players. The game features various ethnic groups. The work contains examples from Spanish, Creole Haitian and Japanese. The linguistic (semantic, lexical, morphological) features of the characters’ speech are studied and described. The characteristic cultural and linguistic features demonstrating the ethnic specificity of the game characters are revealed. The analysis of the material shows the desire of the game discourse for artistic realization through the linguistic features of the characters’ speech and their cultural identity.
EARLY MEDIEVAL TRANSLATION OF ANCIENT TEXTS (ON THE EXAMPLE OF THE "OLD ENGLISH HERBARIUM")
Authors:   St. Petersburg State University, Yakovleva Maria S.
Published: November 2024

The article is dedicated to the study of strategies and tactics that an anonymous medieval translator used for translating a number of ancient texts into Old English. The research material includes Latin medical texts composed in the 4–6th centuries and their translations into Old English (the "Old English Herbarium"), created at the turn of the 10–11th centuries. It is shown that the translation is a compilation of the original texts. The translator made supplements to a number of medical prescriptions and omitted fragments of the original texts unrelated to the healing process. Lexical-semantic substitutions, syntactic replacements in complex sentences, and technical transformations were applied in the translation process. The translator’s goal was to create a medical text relevant to the needs of Anglo-Saxon healers and patients. The resulting text was adapted to the needs of Anglo-Saxon culture and acted as an independent composition in medieval England.
CONCEPT OF MORPHOLOGICAL CATEGORY OF GENDER BASED ON THE THEORY OF LACUNARITY
Authors:   St Petersburg State University, Akay Oksana M. , Rezunenko Irina V. ,   Don State Technical University
Published: November 2024

It is productive to analyze the feminine generic correlates of animate masculine names as intra-linguistic grammatical lacunae. The study of these forms in the paradigm of lacunarity theory allows us to focus on their linguistic and pragmatic characteristics. The gender of nouns in traditional grammar is not accepted to be classified into categories whose functioning is determined by communicative parameters. Moreover, even in communicatively oriented grammatical descriptions, gender is qualified solely on formal syntactic grounds, since for inanimate nouns, obligatory formal agreement on gender ensures grammatical correctness of the utterance. Gender, of course, participates in the structuring of the text as a parameter of cohesion, since anaphoric relations are inseparable from grammatical semantics (nominative or syntactic elements of the content of the antecedent noun). The identity of gender (as well as number) is the minimum condition for the coreference of a name and a pronoun. However, the gender role of the category is by no means limited to ensuring the coherence of the text.
TRANSLATION TRANSFORMATIONS IN THE POLITICAL MEDIA DISCOURSE
Authors:   St Petersburg State University, Neudachina Ludmila V. , Dobrova Tatiana E. ,   St. Petersburg State University, Rubtsova Svetlana Yu. ,   St. Petersburg State University
Published: November 2024

The article presents the result of a comparative analysis of translation transformations in political news texts from English-language media and their translations into Russian. Theoretical issues related to the interpretation of media discourse, news discourse, and news political discourse are outlined. The text is understood as an important component of newspaper discourse. The article is focused on the structural and linguistic features of the news text, describing common types of translation transformations of political news texts in general. As a result of the translation transformations comparative analysis the most common translation techniques typical for political news texts are revealed, namely: transcription and transliteration, grammatical substitutions, lexico-semantic substitutions and complex lexico-semantic transformations.
WEBSITE TRANSLATION AND LOCALISATION: MYTHS AND REALITY
Authors:   Voronezh State University, Shurlina Olga V.
Published: November 2024

This paper deals with the issue of translating the textual content of a website into the language of the target user in the context of localisation. In translation studies, there is still no complete understanding of what localisation is, although the concept itself is often mentioned in academic works. The emphasis is on the multi-dimensional nature of the localisation process, which includes translation. The method used was to compare the textual content of the original and localised versions of the ASOS and Pull&Bear online store websites. The results obtained can be of theoretical importance for the further development of translation issues to be solved during the localisation project. From an applied point of view, they can be useful for translation didactics: they can make it possible to harmonise the knowledge of novice localisation translators in the field of translation theory and avoid mistakes when solving translation tasks.
Jogos na Educação matemática e a constituição de sujeitos-alunos na sociedade neoliberal
Authors: Fogaça Fernando , Wanderer Fernanda , Alfaro Ana María Bermúdez
Published: November 2024

O presente artigo tem por objetivo evidenciar enunciados sobre o uso de jogos na Educação matemática, tendo em vista a constituição de sujeitos-alunos na sociedade neoliberal. O referencial teórico e metodológico se encontra na análise do discurso, como discutido por Michel Foucault. Os materiais utilizados foram trabalhos científicos obtidos em um repositório digital e as duas pesquisas mais citadas nesses documentos, caracterizando-se como um estudo bibliográfico. Mediante uma abordagem qualitativa, mostra-se que o sujeito-aluno, tal como constituído mediante o discurso da Educação matemática atual, gosta de jogos porque são fontes de prazer e motivação – fatores que mitigam a inerente dificuldade da disciplina –, sem deixar de desenvolver a inteligência e o aspecto afetivo/emocional que compõem a cognição. Assim, fortalece-se a tese de que os jogos utilizados na Educação matemática têm funcionado como ferramentas para a constituição de sujeitos alinhados às premissas neoliberais e imersos nas suas demandas.
As condições do trabalho docente e as políticas de reestruturação produtiva do capital
Authors: Gomes Maria Rosilene Maués , Borges Carlos Nazareno Ferreira
Published: November 2024

O estudo aborda condições de trabalho docente no contexto das políticas de reestruturação capitalista. Trata-se de uma seção da tese de doutorado revisada, atualizada e com alguns acréscimos. O objetivo foi analisar a conformidade do trabalho docente na Educação de Jovens, Adultos e Idosos (EJAI) com os interesses do capitalismo. A construção textual fundamentou-se em autores clássicos, como Marx e Engels (1998), e autores contemporâneos, como Freire (2005), Adorno (1995) e Saviani (2007). Trata-se de uma pesquisa de abordagem qualitativa, com base em análise documental, pesquisa de campo, observação, questionário e entrevista semiestruturada. Os resultados revelaram que de um lado há um discurso que sustenta a universalização da educação e a formação dos docentes. De outro, há um controle sobre a escola e a formação dos professores para que se convertam aos interesses do projeto do capital. Revelou, ainda, que o trabalho docente na EJAI é secundarizado e realizado sob orientação do capitalismo.
O uso de drogas ilícitas e suas consequências na saúde oral: Uma revisão de literatura
Authors: Lôbo Lopes da Silva Manuela , Moura Jamille Rios
Published: November 2024

Drogas ilícitas são substâncias que causam dependência e agem provocando alterações comportamentais. O uso dessas substâncias provoca sérios problemas de saúde bucal, caracterizando-se como um grave impasse de saúde pública. O objetivo deste estudo é reunir as consequências do consumo de drogas ilícitas na cavidade bucal, demonstrando a forma como estas interferem na qualidade de vida do usuário. Para isso, realizou-se uma busca nas bases de dados, Biblioteca Virtual em Saúde, Scientific Electronic Library Online (Scielo), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e PubMed/Medline. A maioria dos estudos selecionados inferiu que, os distúrbios psicológicos, decorrentes do uso de substâncias psicoativas, influenciam no descuido com a higiene bucal, sendo que os tecidos orais são diretamente expostos ao uso das drogas ilícitas. Constatou-se que o acesso a serviços odontológicos por este público é dificultado, e ainda há muitos cirurgiões-dentistas que não detêm o conhecimento necessário sobre esta problemática, o que acaba por retardar o diagnóstico e dificulta o tratamento. Assim, é essencial a inserção dos profissionais de odontologia aos programas de saúde bucal direcionado aos usuários de drogas ilícitas, a fim de garantir uma atenção multidisciplinar e possibilitar uma terapêutica eficaz.
Palavras-Chave: Drogas ilícitas; Saúde Bucal; Dependentes Químicos; Saúde Pública.
Planejamento da aposentadoria e os efeitos em trabalhadores: protocolo de revisão sistemática
Authors: Candido Pedro Danielli Rafaeli , Haddad Maria do Carmo Fernandez Lourenço , Mendonça Fernanda Santiago Santos , Salci Maria Aparecida
Published: November 2024

Introdução: o aumento da população idosa em todo o mundo acarreta a necessidade da construção e implantação de políticas e programas de saúde que atendam às necessidades dessa parcela da população. Método: trata-se de um protocolo de revisão sistemática, de acordo com o checklist Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). Serão incluídos todos os artigos publicados em periódicos científicos que descrevam etapas de desenvolvimento, implantação, avaliação de resultados e/ou efeitos de estratégias de planejamento da aposentadoria. Serão excluídos os artigos completos, mas não disponível na íntegra, que possuem informações incompletas e estudos que não respondem à pergunta de pesquisa. Serão utilizadas cinco bases de dados para o estudo. Resultados: os resultados serão apresentados utilizando um diagrama de fluxo, conforme preconiza a JBI.  Para facilitar a síntese dos registros incluídos na pesquisa utilizou-se o modelo de quadro. O protocolo foi registrado na International prospective register of systematic reviews (PROSPERO). Discussão: estudos de revisões sistemáticas são potenciais auxiliadores na identificação de ações que impactaram o processo de trabalho ou a saúde dos trabalhadores de forma positiva ou negativa, servindo como importante fonte para a adoção de estratégias que valorizem a saúde e qualidade de vida do trabalhador. Considerações finais: apesar dos diversos benefícios de preparar os trabalhadores para o momento da aposentadoria não encontrou revisões sistemáticas que objetivassem descrever as estratégias existentes para esse planejamento da aposentadoria e os efeitos gerados nos trabalhadores.
Palavras-Chave: Idoso; Aposentadoria; Saúde do Trabalhador; Qualidade de Vida.
Alergia Alimentar: Uma Análise Conceitual, Clínica e Terapêutica
Authors: França Vale dos Anjos Alana , Teixeira Suellen da Silva , Marcondes Rodrigues dos Santos Lígia , Telles Bárbara da Silva Soares
Published: November 2024

A alergia alimentar é caracterizada por uma resposta adversa exagerada a determinados alimentos, sendo normalmente desencadeada pelos seguintes: leite de vaca, ovo, soja, trigo, amendoim, castanha, peixes e crustáceos. Envolve mecanismos imunológicos e pode apresentar sintomas na pele, no trato gastrointestinal e no sistema respiratório. Atualmente, é considerada um problema de saúde pública, uma vez que sua incidência tem aumentado globalmente, causado um impacto significativo na vida dos pacientes alérgicos e de suas famílias. O presente estudo tem como objetivo revisar os conceitos relacionados às reações alérgicas adversas, abordando as estratégias nutricionais por meio da atuação do nutricionista e influência da família na melhora do quadro clínico. Foi realizada uma pesquisa nas bases de dados PubMed, BVS, Scielo, além de sites governamentais, como o Ministério da Saúde, a Associação Brasileira de Alergia e Imunologia e a Sociedade Brasileira de Pediatria. A pesquisa utilizou as palavras-chave: alérgenos, reação alérgica e hipersensibilidade alimentar. Foram incluídos artigos publicados nos últimos 10 anos, de texto completo gratuito, e excluídos aqueles que não se encaixavam no tema. Nos artigos avaliados, as causas da alergia alimentar foram identificadas como diversas e provavelmente resultam de uma interação complexa entre fatores genéticos, dietéticos e ambientais. Enquanto a cura não é alcançada, a prevenção da alergia alimentar continua sendo um desafio devido à sua complexidade e aos múltiplos fatores envolvidos. Conclui-se que um tratamento curativo é altamente necessário, e estudos promissores estão em andamento. Espera-se obter bons resultados, devolvendo, assim, qualidade de vida àqueles que sofrem com esse problema e, consequentemente, a seus familiares.
Palavras-chave: Alérgenos; Reação Alérgica; Hipersensibilidade Alimentar.
Genome-wide Association Studies of Diabetic Kidney Disease in East Asians With Type 2 Diabetes: Achievements and Future Perspectives
Authors: Taurbekova Binura , Mukhtarova Kymbat , Salpynov Zhandos , Almazan Joseph , Atageldiyeva Kuralay , Sarria-Santamera Antonio
Published: November 2024

Diabetic kidney disease is a devastating diabetic complication, affecting up to
half of people suffering from diabetes. The global burden of diabetic kidney disease is
steadily increasing worldwide along with the growing prevalence of type 2 diabetes. The
epidemic rise of type 2 diabetes is primarily observed in Asia, including the East Asian
regions. It is generally accepted that heredity is one of the main determinants in the
pathogenesis of diabetic kidney disease. Since the advent of genome-wide association
studies, numerous studies have been published to identify the genetic loci susceptible to
diabetic kidney disease among diverse populations. Although genome-wide association
studies exploring diabetic kidney disease susceptibility loci have focused primarily on
populations of European descent, a number of novel genetic variants associated with diabetic
kidney disease have also been successfully revealed among East Asians. A comprehensive
analysis of the genetic architecture and pathophysiological pathways of diabetic
kidney disease may allow the identification of new potential therapeutic targets. This review
aimed to summarize genome-wide association studies examining genetic variants
associated with diabetic kidney disease in the populations of East Asian ancestry with
type 2 diabetes and presented our perspective on the future of this field.
Comprehensive Analysis and Experimental Validation of HEPACAM2 as a Potential Prognosis Biomarker and Immunotherapy Target in Colorectal Cancer
Authors: Wang Shouguang , Zhang Lijuan , Li Dongbing , Gou Miaomiao
Published: November 2024

Background:

The role of HEPACAM family member 2 (HEPACAM2) is unclear in
colorectal cancer (CRC).

Objective:

The objective of this study was to perform an extensive examination of HEPACAM2
and validate it experimentally in CRC.

Methods:

This study investigated the significance of HEPACAM2 in CRC and its potential diagnostic
utility utilizing data from the Cancer Genome Atlas (TCGA) database. Additionally, the
study examined potential regulatory networks involving HEPACAM2, including its associations
with immune infiltration, immune checkpoint genes, tumor mutational burden (TMB), microsatellite
instability (MSI), mRNA expression-based stemness index (mRNAsi), and drug sensitivity in
CRC. The expression of HEPACAM2 was further validated using the GSE89076 dataset, and
quantitative reverse transcription PCR (qRT-PCR) was employed to confirm HEPACAM2 expression
levels in six pairs of CRC tissue samples.

Results:

HEPACAM2 exhibited abnormal expression patterns in various types of cancer, including
CRC. A decrease in HEPACAM2 expression levels in CRC was found to be significantly correlated
with the T stage (p < 0.001). Reduced HEPACAM2 expression in CRC patients was also
linked to poorer overall survival (OS) (p = 0.007). The expression levels of HEPACAM2 in CRC
patients were identified as an independent prognostic factor (p = 0.016). Furthermore, HEPACAM2
was associated with TCF-dependent signaling in response to WNT, G2/M checkpoints,
and other pathways. The expression of HEPACAM2 in CRC was found to be associated with immune
infiltration, immune checkpoint genes, TMB / MSI, and mRNAsi. Additionally, the expression
of HEPACAM2 in CRC was significantly and inversely correlated with the drug sensitivities
to gw772405x and 6-phenyl-6h-indeno[1,2-c]isoquinoline-5,11-dione. qRT-PCR confirmed that
the expression level of HEPACAM2 was found to be lowly expressed in CRC tissues.

Conclusion:

These findings suggest that HEPACAM2 may serve as a potential prognostic biomarker
and immunotherapeutic target for CRC patients.
Synthesis, Biological Evaluation, Molecular Docking Studies and ADMET Prediction of Oxindole-Based Hybrids for the Treatment of Tuberculosis
Authors: Patel Vaishali Pavalbhai , Tripathi Rati Kailash Prasad , Mandal Snigdha Das
Published: November 2024

Introduction:

With a projected mortality toll of 1.4 million in 2019, tuberculosis
(TB) continues to be a significant public health concern around the world. Studies of novel
treatments are required due to decreased bioavailability, increased toxicity, increased side effects,
and resistance of several first- and second-line TB therapies, including isoniazid and ethionamide.

Methods:

This study reports the synthesis of oxindole-based hybrids as potent InhA inhibitors
targeting Mycobacterium tuberculosis. The synthesized compounds (5a-5e and 8a-8c) were
evaluated for their anti-mycobacterial activity against Mycobacterium tuberculosis and nontuberculous
mycobacteria (NTMs), viz. M. abscessus (ATCC 19977), M. fortuitum (ATCC 6841),
and M. chelonae (ATCC 35752) using the Microplate Alamar Blue Assay (MABA). Molecular
docking studies were performed using AutoDock Vina to explore the binding interactions of
these compounds with the InhA enzyme (PDB: 2NSD). Additionally, biochemical and histopathological
studies were conducted to assess the hepatotoxicity of the lead compounds. Insilico
molecular properties and ADMET properties of the synthesized compounds were predicted
using SwissADME and Deep-PK online tools to assess their drug-likeness.

Results:

Among the tested compounds, 8b exhibited significant anti-mycobacterial activity with
a minimum inhibitory concentration (MIC = 1 μg/mL) comparable to the reference drug ethambutol.
Further, the compound demonstrated a binding affinity and orientation similar to the reference
inhibitor 4PI, indicating its potential as a potent InhA inhibitor, and was found to be stabilized
within the binding pocket of InhA through H-bonding, hydrophobic and van der Waal’s
interactions. Besides, the compounds hepatotoxicity assessment studies depicted that 8b showed
no significant liver dysfunction or damage to liver tissues. Additionally, 8b adhered to
Lipinski’s rule of five and Veber’s rule, displaying favourable pharmacokinetic and drug-like
properties, including high human intestinal absorption, distribution, and acceptable metabolic
stability and excretion.

Conclusion:

Compound 8b emerged as a promising candidate for further optimization and development
as a therapeutic agent for tuberculosis, offering a new avenue for tackling tuberculosis.
Robust Somatic Copy Number Estimation using Coarse-to-fine Segmentation
Authors: Culibrk Luka , Grewal Jasleen K. , Pleasance Erin D. , Williamson Laura M. , Mungall Karen , Laskin Janessa , Marra Marco A. , Jones Steven J.M.
Published: November 2024

Introduction:

Cancers routinely exhibit chromosomal instability that results in copy
number variants (CNVs), namely changes in the abundance of genomic material. Unfortunately, the
detection of these variants in cancer genomes is difficult.

Methods:

We present Ploidetect, a software package that effectively identifies CNVs within wholegenome
sequenced tumors. Ploidetect utilizes a coarse-to-fine segmentation approach which yields
highly contiguous segments while allowing for focal CNVs to be detected with high sensitivity.

Results:

We benchmark Ploidetect against popular CNV tools using synthetic data, cell line data,
and real-world metastatic tumor data and demonstrate strong performance in all tests. We show that
high quality CNVs from Ploidetect enable the identification of recurrent homozygous deletions and
genes associated with chromosomal instability in a multi-cancer cohort of 687 patients. Using highly
contiguous CNV calls afforded by Ploidetect, we also demonstrate the use of segment N50 as a
novel metric for the measurement of chromosomal instability within tumor biopsies.

Conclusion:

We propose that the increasingly accurate determination of CNVs is critical for their
productive study in cancer, and our work demonstrates advances made possible by progress in this
regard.
GVNNVAE: A Novel Microbe-Drug Association Prediction Model based on an Improved Graph Neural Network and the Variational Auto-Encoder
Authors: Chen Yiming , Zhang Zhen , Liu Xin , Zeng Bin , Wang Lei
Published: November 2024

Microorganisms play a crucial role in human health and disease. Identifying potential microbe-
drug associations is essential for drug discovery and clinical treatment. In this manuscript, we
proposed a novel prediction model named GVNNVAE by combining an Improved Graph Neural
Network (GNN) and the Variational Auto-Encoder (VAE) to infer potential microbe-drug associations.
In GVNNVAE, we first established a heterogeneous microbe-drug network N by integrating
multiple similarity metrics of microbes, drugs, and diseases. Subsequently, we introduced an improved
GNN and the VAE to extract topological and attribute representations for nodes in N respectively.
Finally, through incorporating various original attributes of microbes and drugs with above
two kinds of newly obtained topological and attribute representations, predicted scores of potential
microbe-drug associations would be calculated. Furthermore, To evaluate the prediction performance
of GVNNVAE, intensive experiments were done and comparative results showed that
GVNNVAE could achieve a satisfactory AUC value of 0.9688, which outperformed existing competitive
state-of-the-art methods. And moreover, case studies of known microbes and drugs confirmed
the effectiveness of GVNNVAE as well, which highlighted its potential for predicting latent
microbe-drug associations.
Nanoparticle Carriers: A New Era of Precise CRISPR/Cas9 Gene Editing
Authors: SHARMA BHAWNA , Chauhan Iti , Kumar Gaurav , Bhardwaj Khushboo , Tiwari Raj Kumar
Published: November 2024

The revolutionary CRISPR/Cas9 gene editing technology holds immense potential for
treating genetic diseases and tackling conditions like cancer. However, efficient delivery remains
a significant challenge. This is where nanoparticles come into play, emerging as powerful allies
in the realm of drug delivery. Nanoparticles can accommodate larger insertion sizes, enabling the
incorporation of larger Cas9 enzymes and complex guide RNAs, thus opening up the possibility
of editing previously inaccessible genetic regions. Their relatively straightforward and scalable
production processes make them cost-effective options for wider applications. Notably, nanoparticles
excel in vivo, demonstrating efficient tissue penetration and targeted delivery, which are
crucial for maximizing therapeutic impact while minimizing side effects.

This review aims to explore the potential of nanoparticle-based delivery systems for
CRISPR/Cas9, highlighting their advantages and challenges in gene editing applications. The
diverse range of nanoparticles further bolsters their potential. Polymeric nanoparticles, for instance,
offer tunable properties for customization and controlled release of the CRISPR cargo.
Lipid-based nanoparticles facilitate efficient cellular uptake and endosomal escape, ensuring the
CRISPR components reach the target DNA. Even gold nanoparticles, known for their unique
biocompatibility and photothermal properties, hold promise in light-activated editing strategies.
Non-viral delivery systems, particularly those based on nanoparticles, stand out due to their inherent
advantages.

Collectively, the evidence paints a promising picture: nanoparticles are not merely passive carriers
but active participants in the CRISPR/Cas9 delivery landscape. Their versatility, efficiency,
and safety position them as key enablers of a future where gene editing can revolutionize drug
development, offering personalized and targeted therapies for a wide range of diseases.
A Review on Silver Nanoparticles: Synthesis Approaches, Properties, Characterization and Applications
Authors: C K Vishveshwaraiah , G B Kirankumar , M Harshitha , B K Madhu
Published: November 2024

Nanoparticles are a significant topic due to their applications in various fields, including
biology, optics, catalysis, pharmaceutics, health, agriculture, and industry, with biosynthesis processes
being quick, easy, and environmentally friendly. Due to their applications across multiple industries,
silver nanoparticles, or AgNPs, have become the most desired nanoparticles with the recent
development of nanotechnology. The physical, chemical, and biological characteristics of AgNPs
are being studied. These characteristics are crucial for limiting the hazards associated with silver nanoparticles
while optimizing their potential applications in many fields. A higher degree of toxicity
in both the environment and living things could arise from the increasing use of silver nanoparticles
in the product. Silver nanoparticles find application in wound care, anti-infective therapy, food,
pharmaceutical, and cosmetic industries. As antioxidant, antiviral, anticancer, antifungal, antiinflammatory,
and microbiological agents, silver nanoparticles are widely used. Not only must the
particles be nanoscale in order for silver nanoparticles to be present, but their production must also
be simple and inexpensive to achieve. This paper aims to review the different methods of synthesis
of silver nanoparticles, properties, characterization, and their applications. In specific, several chemical
and green synthesis approaches for synthesising silver nanoparticles have been discussed. The
morphology, size, thermal properties, toxicity properties, electrical properties, catalytic properties,
and applications of silver nanoparticles are focused. The main focus is on the effective and efficient
synthesis of pure silver nanoparticles and their potential applications.
QSAR Modeling and Molecular Docking Studies of New Substituted Pyrazolyl-Pyrimidinones as Potent HIV-1 Inhibitors
Authors: Hamdache Badr , Tabti Kamal , Er-rajy Mohammed , Dib Mustapha , ElFarouki Khadija , Ouchetto Khadija , Elhalaoui Menana , Hafid Abderrafia , Khouili Mostafa , Ouchetto Hajiba
Published: November 2024

Background:

Pyrazolyl-pyrimidinone derivatives are important heterocyclic compounds.
A novel HIV-1 (human immunodeficiency virus type 1) inhibitors based on these components were
designed as potential drug candidates for AIDS (acquired immunodeficiency syndrome) therapy.

Objective:

This research aims to develop a predictive mathematical model linking the biological activity
and physicochemical properties of pyrazolyl-pyrimidinones derivatives and to identify the interactions
between the most active compound and the HIV-1 active site.

Method:

A QSAR-2D study was conducted on 40 pyrazolyl-pyrimidinone derivatives, followed by
molecular docking of the most active compounds.

Results:

Principal Component Analysis (PCA) was used to select the best descriptors for building
QSAR models using Multiple Linear Regression (MLR), Multiple Nonlinear Regression (MNLR),
and Artificial Neural Networks (ANN). The MLR model achieved R² = 0.70, Q²Cv = 0.54, and successful
Y-randomization (R = 0.83). The MNLR model had an R² of 0.81 and low mean square error
RMSE = 0.17, while the ANN model showed ρ = 1.5 and RMSE = 0.15. Docking studies confirmed
key interactions between compounds 1 and 11 with the HIV-1 active site. The results of molecular
packaging Substances 11 and 1 have the lowest energy levels of -13.26 kcal/mol and -12.5
kcal/mol, respectively, and have more than one hydrogen bond. The molecular docking validation
finds RMSD = 0.821.

Conclusion:

This study allowed the establishment of robust QSAR models with a good predictive
capacity, confirmed by several statistical indicators, with the aim of inhibiting HIV-1. The models
showed satisfactory reliability and docking studies identified key interactions between the compounds
and the active sites of HIV-1, thus reinforcing their profile as promising candidates for the
development of new antiviral treatments.
Bipolar Expected Value-based MCDM Technique for Wastewater Management under Trapezoidal Bipolar Fuzzy Environment
Authors: Garai Totan
Published: November 2024

:

Kolkata is located on western bank of the Hooghly River. Wastewater from the city is discharged into this river and pollutes the river water. It causes maximum negative effects than positive impacts. Many uncertainties and bipolarity occur for this reason. Through the bipolar fuzzy concept, we can easily take the determination for this situation. A bipolar fuzzy expected is an effective tool for illustrating uncertainty and fuzziness in a decision-making problem. There-fore, in this paper, we have invented the bipolar expected value of bipolar fuzzy numbers. In addition, we have invented a few formulae and a theorem based on bipolar expected values. Using this bipolar expected value, we developed a novel MCDM technique, and it's employed for wastewater management problems in Kolkata city under a bipolar environment. Numerically, we have solved the wastewater management problem under a bipolar fuzzy environment.
Environment-friendly Synthesis of AgNPs from Fimbristylis miliacea Flower Extract: Characterization and its Applications as an Antioxidant Activity, Anticancerous Activity and in the Reduction of 4-Nitrophenol
Authors: Patil Pandurang Y. , Manjare Satish B. , Jadhav Rujuda R.
Published: November 2024

Background:

Silver metal is useful in a variety of fields. Different silver salts exhibit
good application in the organic transformation. The use of a green methodology in AgNPs preparation
has gained interest of young researchers. Plant systems are employed in the green approach
of preparing AgNPs, serving as both a stabilizing and reducing agent. Silver nanoparticles
(AgNPs) made from silver salts exhibit a variety of biological activities and may be useful in organic
transformation.

Method:

AgNPs were synthesized with the use of flower extract from Fimbristylis miliacea,
which acts as a stabilizing and reducing agent.

Result:

Fimbristylis miliacea flower extract is used as a reducing and stabilising agent for preparation
of AgNPs. These synthesised AgNPs were characterised by using FTIR, XRD, FESEM/
EDS, HR-TEM, TGA, and ICP-AES. Fimbristylis milliciea flower extract was subjected to
FTIR and HR-LCMS analysis in order to identify the phytoconstituents that are responsible for the
reduction of AgNO3. The HR-TEM shows particle size between 8.98434+0.69669nm and
19.07464+1.4384nm. The size of AgNPs determined by using HR-TEM shows good agreement
with XRD particle size. The synthesized AgNPs show excellent antioxidant properties with
IC50=56.45 μg/mL. The present study confers significant cytotoxic activity against MDA-MB-231
human breast cancer cell line culture (IC50= 61.97 μg/ml). The AgNPs show a faster reduction of
4-nitrophenol.

Conclusion:

In conclusion, we have prepared AgNPs by using Fimbristylis miliacea flower extract.
The study further concludes that green synthesis of AgNPs has many advantages as compared
to chemical methods, such as cost-effectiveness, rapid, and environment-friendly methods.
The results indicated that the biosynthesized AgNPs have significant cytotoxic activity against the
MDA-MB-231 breast cancer cell line. Further, it indicates that biosynthesized AgNPs can be a
potential alternative agent for human breast cancer therapy. The cytotoxic potential can be used
for treatments and provides a new method to develop molecules for cancer therapy. The catalytic
activity of AgNPs was examined by using the reduction of 4-nitrophenol. It shows that the reduction
of 4-nitrophenol in 6 minutes is confirmed by using 1H NMR analysis.
Onde está a Mesquita Aljama de Lisboa? Da construção de um mito urbano aos equívocos da Arqueologia
Authors: Gomes Rosa Varela , Gomes Mário Varela
Published: November 2024

The city of Lisbon, heir to an opulent Islamic past, has insisted on hiding its testimonies of buildings from that period. Nonetheless, since the 19th century and under the infl uence of Romanticism and along with the birth of Archaeology as a Science, that from the study of ancient literary information, the presence of some important constructions and, in particular, the great aljama or main mosque was given value. Archaeological excavations carried out in the cloister of the Lisbon Cathedral (Sé de Lisboa), which have been going on for three decades, claimed to have discovered the remains of that temple, which, well-orchestrated campaign in the media, made them widely reported. However, not even with some imagination is it believable that the remains of the structures exposed have belonged to the desired main mosque, as they do not have constructive or convincing morphological characteristics capable of supporting such a statement, such as the undeniable remains of the mihrāb, the qibla or the minaret, tiled or stone fl ooring, bases, shafts or column capitals, fragments of decorated stucco, inscriptions, etc. Nor were there any artifactual testimonies or stratigraphic successions identifi ed that contributed to that interpretation.
Towards a Counterhistory of the Western Sahara
Authors: Gimeno Martín Juan Carlos , Robles Picón Juan Ignacio
Published: November 2024

This article is the product of research in co-labor between Saharawi and Spanish researchers. It proposes a first approach to the construction of a counter-history of Western Sahara, dating from 1884, the date of the arrival and installation of the first Spaniards on the coast of the territory, until the “pacification” of 1934. This counter-history Demands a post-colonial and decolonized look to review the hegemonic stories about the region. This revision is, on the other hand, the necessary condition to undertake in parallel a counter-history of twentieth-century Europe.
Environmental Reflections of Plundering Natural resources of Western Sahara
Authors: Zber Ghali
Published: November 2024

The continuous and extensive exploitation of natural resources in Western Sahara has undeniably negative consequences for the environment. However, there is a notable lack of significant studies investigating its environmental repercussions. The marine resources in Western Sahara, exploited by foreign fleets for decades and further depleted under Moroccan occupation, have reached alarming levels. The extraction, transportation, and processing of phosphate rocks from the Boukraa mine, one of the world’s largest phosphate mines, have resulted in severe pollution, which pose substantial health risks and contaminate water sources, air quality, soil, and the marine ecosystem. The absence of an effective environmental policy enforced by the Moroccan occupation is directly responsible for this damaging environmental state.
The impact of electronic marketing on the purchase behavior of Saudi consumers: An empirical study
Authors:   Department of Business Administration, College of Business, Jouf University, Sakaka, Saudi Arabia, Al-Ruwaili Sami Khatam Gubir , Al-Matari Ebrahim Mohammed ,   Department of Accounting, College of Business, Jouf University, Sakaka, Saudi Arabia,   Faculty of Commerce and Economics, Amran University, Amran, Yemen, Alnor Nasareldeen Hamed Ahmed ,   Department of Accounting, College of Business, Jouf University, Sakaka, Saudi Arabia, Ahmed Afaf ,   Business Administration Program, Applied College, King Khalid University, Sarat Abidah, Saudi Arabia, Khogaly Mohamed Elnair Mohamedain ,   Department of Administrative and Financial Sciences, Al-Khafji University College, University of Hafr Al Batin, Al-Khafji, Saudi Arabia, Mahdi Duriya Balla Ahmed ,   Accounting Department, College of Business Administration, Taif University, Taif, Saudi Arabia, Abdelraheem Abubkr Ahmed Elhadi ,   Accounting Department, College of Business Administration, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia
Published: November 2024

This study aimed to investigate how e-marketing and its various aspects affect the buying habits of Saudi consumers in the service industry in the Al-Jouf region. The researchers used the Partial Least Squares Structural Equation Modeling (PLS-SEM) method to analyze the model after collecting data from the service sector in the Al-Jouf region. The statistical results showed a significant correlation between marketing activities and the purchasing behavior of Saudi consumers, consistent with previous studies. Additionally, the study found a statistically significant relationship between individual factors and the purchasing behavior of Saudi consumers, also in line with previous research. Finally, the study demonstrated a statistically significant link between tangible elements and the purchasing behavior of Saudi consumers. This study offers several important insights that will be valuable for future researchers looking to improve this area of study.