bluuebunny/crossref_metadata_2025 huggingface dataset:
Current Status and Future Perspectives of Androgen Receptor Inhibition Therapy for Prostate Cancer: A Comprehensive Review
Authors: Kim Tae Jin , Lee Young Hwa , Koo Kyo Chul
Published: March 2021

The androgen receptor (AR) is one of the main components in the development and progression of prostate cancer (PCa), and treatment strategies are mostly directed toward manipulation of the AR pathway. In the metastatic setting, androgen deprivation therapy (ADT) is the foundation of treatment in patients with hormone-sensitive prostate cancer (HSPC). However, treatment response is short-lived, and the majority of patients ultimately progress to castration-resistant prostate cancer (CRPC). Surmountable data from clinical trials have shown that the maintenance of AR signaling in the castration environment is accountable for disease progression. Study results indicate multiple factors and survival pathways involved in PCa. Based on these findings, the alternative molecular pathways involved in PCa progression can be manipulated to improve current regimens and develop novel treatment modalities in the management of CRPC. In this review, the interaction between AR signaling and other molecular pathways involved in tumor pathogenesis and its clinical implications in metastasis and advanced disease will be discussed, along with a thorough overview of current and ongoing novel treatments for AR signaling inhibition.
Saccharomyces cerevisiae as a Toolkit for COP9 Signalosome Research
Authors: Harshuk-Shabso Dana , Castel Noam , Israeli Ran , Harari Sheri , Pick Elah
Published: March 2021

The COP9 signalosome (CSN) is a highly conserved eukaryotic multi-subunit enzyme, regulating cullin RING ligase activities and accordingly, substrate ubiquitination and degradation. We showed that the CSN complex of Saccharomyces cerevisiae that is deviated in subunit composition and in sequence homology harbors a highly conserved cullin deneddylase enzymatic core complex. We took advantage of the non-essentiality of the S. cerevisiae CSN-NEDD8/Rub1 axis, together with the enzyme-substrate cross-species activity, to develop a sensitive fluorescence readout assay, suitable for biochemical assessment of cullin deneddylation by CSNs from various origins. We also demonstrated that the yeast catalytic subunit, CSN5/Jab1, is targeted by an inhibitor that was selected for the human orthologue. Treatment of yeast by the inhibitor led to the accumulation of neddylated cullins and the formation of reactive oxygen species. Overall, our data revealed S. cerevisiae as a general platform that can be used for studies of CSN deneddylation and for testing the efficacy of selected CSN inhibitors.
Technologies and Sensor Design for the Measurement of Ground Reaction Forces in Mice: A Review
Authors: Limam Tayssir , Vogl Florian , Taylor William R.
Published: March 2021

To better understand the pathophysiology and functional outcomes of musculoskeletal and neuromotor pathologies, research is often conducted in mice models. As a key component of such research, metrics of movement, loading, symmetry, and stability all have to be assessed, ideally requiring the measurement of 3D ground reaction forces, which can be difficult. While the measurement of ground reaction forces (GRF) is well developed for humans, appropriate devices for mice remain rare or inadequate. Such devices need to combine high sensitivity with small dimensions, especially when the forces for each individual paw should be measured. As preparation for building such a device that can measure 3D GRF per paw in mice in an upcoming study, this systematic review of the literature identified 122 articles and 49 devices that measured the ground reaction forces for mice and other small animals. Based on a variety of criteria, such as sensitivity and resonance frequency, the miniaturisation of each device and/or its capability to measure the three components of the ground reaction forces in individual paws were judged. The devices were consequently classified; eight devices were classified as “can be adapted”, nine as “hard to be adapted”, and 24 as “cannot be adapted”.
Nanomarker for Early Detection of Alzheimer’s Disease Combining Ab initio DFT Simulations and Molecular Docking Approach
Authors: Ferreira Schopf Patricia , Zanella Ivana , D. S. Cordeiro M. Natália , Ruso Juan M. , González-Durruthy Michael , Ortiz Martins Mirkos
Published: March 2021

The tau protein is considered an important qualitative and quantitative biomarker for Alzheimer’s disease in its asymptomatic phase. In 2011, biomarkers were suggested by the National Institute on Aging-Azheimer’s Association as a new criterion for the early diagnosis of Alzheimer’s disease. Thus, highlighting the non-existence of theoretical research on the subject, we investigated the binding interaction properties between phosphorylated tau protein and a theoretically modeled ligands constituted by the fullerol functionalized with radiopharmaceuticals from an in silico approach via molecular docking and density functional theory (DFT) ab initio computational simulation. The results demonstrated that the ligand with the greatest affinity-based binding energy to the protein was fullerol + F-THK5105. However, all systems were considered promising for the development of a potential diagnostic nanomarker. These theoretical results could efficiently contribute to reduce the time and the cost for future experimental preclinical studies and open new opportunities toward molecular recognition in nanomedicine.
Phase-Dependent Deep Brain Stimulation: A Review
Authors: Kumari Lekshmy , Kouzani Abbas
Published: March 2021

Neural oscillations are repetitive patterns of neural activity in the central nervous systems. Oscillations of the neurons in different frequency bands are evident in electroencephalograms and local field potential measurements. These oscillations are understood to be one of the key mechanisms for carrying out normal functioning of the brain. Abnormality in any of these frequency bands of oscillations can lead to impairments in different cognitive and memory functions leading to different pathological conditions of the nervous system. However, the exact role of these neural oscillations in establishing various brain functions is still under investigation. Closed loop deep brain stimulation paradigms with neural oscillations as biomarkers could be used as a mechanism to understand the function of these oscillations. For making use of the neural oscillations as biomarkers to manipulate the frequency band of the oscillation, phase of the oscillation, and stimulation signal are of importance. This paper reviews recent trends in deep brain stimulation systems and their non-invasive counterparts, in the use of phase specific stimulation to manipulate individual neural oscillations. In particular, the paper reviews the methods adopted in different brain stimulation systems and devices for stimulating at a definite phase to further optimize closed loop brain stimulation strategies.
Intelligence-Based Design Illustrated with Examples of ACROS Fukuoka, KKL Luzern and MICA Changsha Buildings—A Multicriterial Case Study
Authors: Majerska-Pałubicka Beata , Latusek Elżbieta
Published: March 2021

The article concerns the issue of intelligence-based design, which, during the design process undertaken by architects, signifies (according to the authors of the article) thinking about perceptual involvement in the built environment, designing together with people and for people and not forgetting about conveniences brought by technological progress. The way to smart cities, in respect of architectural solutions, leads (to a significant extent) through the smart design of multifunctional buildings based on the idea of sustainable development. The article-related research involved multiple case studies including three buildings, i.e., Asian Cross Road Over the Sea (ACROS) in Fukuoka, Kultur- und Kongresszentrum Luzern (KKL) in Luzern and Changsha Meixihu International Contemporary Art Museum (MICA) in Changsha. The above-named buildings, located in different countries, i.e., Japan, Switzerland and China, respectively, and erected within various time spans, i.e., the 1990s–2020, are characterized by primary common features—multifunctionality, large cubature and comparable program elements. The research presented in this article aimed to find and present the elements of intelligence-based design in the buildings and perform their comparative analysis taking into consideration the fact that the buildings were erected within the span of 30 years. The article presents a graphic comparative analysis of the intelligence-based design, a multicriterial case study (encompassing the concept, functional and spatial solutions and structure) of selected architectural objects. The article includes also a graphic comparative analysis of the very objects and concert halls: Fukuoka Symphony Hall (ACROS), Salle Blanche (KKL) and Hunan Grand Theatre (MICA).
Ultra-Thin Carbon Films: The Rise of sp3-C-Based 2D Materials?
Authors: Piazza Fabrice , Monthioux Marc
Published: March 2021

We warmly thank all the colleagues who have enthusiastically participated in the project of this Special Issue on “2D Ultra-Thin Carbon Films”, considering a globally unfavorable context characterized by (i) a myriad of publication options; (ii) strong pressure, by the highly competitive research (and researcher) funding and evaluation system, to publish in high impact factor journals, specifically for topics of worldwide interest; and (iii) all sorts of restrictions imposed by the sanitary crisis [...]
The Constitutive Extracellular Protein Release by Acute Myeloid Leukemia Cells—A Proteomic Study of Patient Heterogeneity and Its Modulation by Mesenchymal Stromal Cells
Authors: Aasebø Elise , Brenner Annette K. , Birkeland Even , Tvedt Tor Henrik Anderson , Selheim Frode , Berven Frode S. , Bruserud Øystein
Published: March 2021

Extracellular protein release is important both for the formation of extracellular matrix and for communication between cells. We investigated the extracellular protein release by in vitro cultured normal mesenchymal stem cells (MSCs) and by primary human acute myeloid leukemia (AML) cells derived from 40 consecutive patients. We observed quantifiable levels of 3082 proteins in our study; for the MSCs, we detected 1446 proteins, whereas the number of released proteins for the AML cells showed wide variation between patients (average number 1699, range 557–2380). The proteins were derived from various cellular compartments (e.g., cell membrane, nucleus, and cytoplasms), several organelles (e.g., cytoskeleton, endoplasmatic reticulum, Golgi apparatus, and mitochondria) and had various functions (e.g., extracellular matrix and exosomal proteins, cytokines, soluble adhesion molecules, protein synthesis, post-transcriptional modulation, RNA binding, and ribonuclear proteins). Thus, AML patients were very heterogeneous both regarding the number of proteins and the nature of their extracellularly released proteins. The protein release profiles of MSCs and primary AML cells show a considerable overlap, but a minority of the proteins are released only or mainly by the MSC, including several extracellular matrix molecules. Taken together, our observations suggest that the protein profile of the extracellular bone marrow microenvironment differs between AML patients, these differences are mainly caused by the protein release by the leukemic cells but this leukemia-associated heterogeneity of the overall extracellular protein profile is modulated by the constitutive protein release by normal MSCs.
Classification of Molecular Subtypes of High-Grade Serous Ovarian Cancer by MALDI-Imaging
Authors: Kassuhn Wanja , Klein Oliver , Darb-Esfahani Silvia , Lammert Hedwig , Handzik Sylwia , Taube Eliane T. , Schmitt Wolfgang D. , Keunecke Carlotta , Horst David , Dreher Felix , George Joshy , Bowtell David D. , Dorigo Oliver , Hummel Michael , Sehouli Jalid , Blüthgen Nils , Kulbe Hagen , Braicu Elena I.
Published: March 2021

Despite the correlation of clinical outcome and molecular subtypes of high-grade serous ovarian cancer (HGSOC), contemporary gene expression signatures have not been implemented in clinical practice to stratify patients for targeted therapy. Hence, we aimed to examine the potential of unsupervised matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) to stratify patients who might benefit from targeted therapeutic strategies. Molecular subtyping of paraffin-embedded tissue samples from 279 HGSOC patients was performed by NanoString analysis (ground truth labeling). Next, we applied MALDI-IMS paired with machine-learning algorithms to identify distinct mass profiles on the same paraffin-embedded tissue sections and distinguish HGSOC subtypes by proteomic signature. Finally, we devised a novel approach to annotate spectra of stromal origin. We elucidated a MALDI-derived proteomic signature (135 peptides) able to classify HGSOC subtypes. Random forest classifiers achieved an area under the curve (AUC) of 0.983. Furthermore, we demonstrated that the exclusion of stroma-associated spectra provides tangible improvements to classification quality (AUC = 0.988). Moreover, novel MALDI-based stroma annotation achieved near-perfect classifications (AUC = 0.999). Here, we present a concept integrating MALDI-IMS with machine-learning algorithms to classify patients according to distinct molecular subtypes of HGSOC. This has great potential to assign patients for personalized treatment.
Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention
Authors: Fhu Chee Wai , Ali Azhar
Published: March 2021

The ubiquitin proteasome system (UPS) governs the non-lysosomal degradation of oxidized, damaged, or misfolded proteins in eukaryotic cells. This process is tightly regulated through the activation and transfer of polyubiquitin chains to target proteins which are then recognized and degraded by the 26S proteasome complex. The role of UPS is crucial in regulating protein levels through degradation to maintain fundamental cellular processes such as growth, division, signal transduction, and stress response. Dysregulation of the UPS, resulting in loss of ability to maintain protein quality through proteolysis, is closely related to the development of various malignancies and tumorigenesis. Here, we provide a comprehensive general overview on the regulation and roles of UPS and discuss functional links of dysregulated UPS in human malignancies. Inhibitors developed against components of the UPS, which include U.S. Food and Drug Administration FDA-approved and those currently undergoing clinical trials, are also presented in this review.
OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence
Authors: Megiorni Francesca , Camero Simona , Pontecorvi Paola , Camicia Lucrezia , Marampon Francesco , Ceccarelli Simona , Anastasiadou Eleni , Bernabò Nicola , Perniola Giorgia , Pizzuti Antonio , Benedetti Panici Pierluigi , Tombolini Vincenzo , Marchese Cinzia
Published: March 2021

Ovarian cancer (OC) is the most aggressive gynecological tumor worldwide and, notwithstanding the increment in conventional treatments, many resistance mechanisms arise, this leading to cure failure and patient death. So, the use of novel adjuvant drugs able to counteract these pathways is urgently needed to improve patient overall survival. A growing interest is focused on epigenetic drugs for cancer therapy, such as Bromodomain and Extra-Terminal motif inhibitors (BETi). Here, we investigate the antitumor effects of OTX015, a novel BETi, as a single agent or in combination with ionizing radiation (IR) in OC cellular models. OTX015 treatment significantly reduced tumor cell proliferation by triggering cell cycle arrest and apoptosis that were linked to nucleolar stress and DNA damage. OTX015 impaired migration capacity and potentiated IR effects by reducing the expression of different drivers of cancer resistance mechanisms, including GNL3 gene, whose expression was found to be significantly higher in OC biopsies than in normal ovarian tissues. Gene specific knocking down and computational network analysis confirmed the centrality of GNL3 in OTX015-mediated OC antitumor effects. Altogether, our findings suggest OTX015 as an effective option to improve therapeutic strategies and overcome the development of resistant cancer cells in patients with OC.
Isolation Strategy towards Earth-Abundant Single-Site Co-Catalysts for Photocatalytic Hydrogen Evolution Reaction
Authors: Ayala Pablo , Giesriegl Ariane , Nandan Sreejith P. , Myakala Stephen Nagaraju , Wobrauschek Peter , Cherevan Alexey
Published: March 2021

Achieving efficient photocatalytic water splitting remains one of the most vital challenges in the photocatalysis field, as the performance of contemporary heterogeneous catalysts is still limited by their insufficient activity and low predictability. To address this challenge, this work takes inspiration from the concept of heterogeneous single-metal-site catalysts (HSMSCs) and follows the idea of site-isolation, aiming towards single-site co-catalyst species and a higher atom-utilization efficiency. We synthesized a set of photocatalysts through an adsorption-limited wet impregnation process using bare and phosphate-modified TiO2 as model supports and earth-abundant metals (Cu and Ni) with various loadings (0.008–5 wt.%) as co-catalyst species. The catalysts are characterized by TXRF for the determination of the real co-catalyst loadings, UV-vis and FTIR spectroscopes for semi-quantitative analysis of the metal state and binding modes to the substrate, and HRTEM for resolving the morphology of the sample’s surface. All samples were then evaluated towards the photocatalytic hydrogen evolution reaction (HER). We show that much higher turnover frequencies (TOFs) are obtained for both Cu- and Ni-based systems when lower co-catalyst loadings are used, which indicates an improved atom-utilization efficiency that reaches performances comparable to the noble Au co-catalyst. We also introduce a structural model to explain the observed TOF trends, which confirms that both earth-abundant systems undergo a strong structural reconstruction upon site-isolation towards smaller, perhaps even single-site-like species.
Low-Dimensional Nanostructured Photocatalysts for Efficient CO2 Conversion into Solar Fuels
Authors: Omr Hossam A. E. , Horn Mark W. , Lee Hyeonseok
Published: March 2021

The ongoing energy crisis and global warming caused by the massive usage of fossil fuels and emission of CO2 into atmosphere continue to motivate researchers to investigate possible solutions. The conversion of CO2 into value-added solar fuels by photocatalysts has been suggested as an intriguing solution to simultaneously mitigate global warming and provide a source of energy in an environmentally friendly manner. There has been considerable effort for nearly four decades investigating the performance of CO2 conversion by photocatalysts, much of which has focused on structure or materials modification. In particular, the application of low-dimensional structures for photocatalysts is a promising pathway. Depending on the materials and fabrication methods, low-dimensional nanomaterials can be formed in zero dimensional structures such as quantum dots, one-dimensional structures such as nanowires, nanotubes, nanobelts, and nanorods, and two-dimensional structures such as nanosheets and thin films. These nanostructures increase the effective surface area and possess unique electrical and optical properties, including the quantum confinement effect in semiconductors or the localized surface plasmon resonance effect in noble metals at the nanoscale. These unique properties can play a vital role in enhancing the performance of photocatalytic CO2 conversion into solar fuels by engineering the nanostructures. In this review, we provide an overview of photocatalytic CO2 conversion and especially focus on nanostructured photocatalysts. The fundamental mechanism of photocatalytic CO2 conversion is discussed and recent progresses of low-dimensional photocatalysts for efficient conversion of CO2 into solar fuels are presented.
MFG-E8 Plays an Important Role in Attenuating Cerulein-Induced Acute Pancreatitis in Mice
Authors: Bu Heng-Fu , Subramanian Saravanan , Geng Hua , Wang Xiao , Liu Fangyi , Chou Pauline M. , Du Chao , De Plaen Isabelle G. , Tan Xiao-Di
Published: March 2021

Milk fat globule-EGF factor 8 (MFG-E8) is a secreted glycoprotein that regulates tissue homeostasis, possesses potent anti-inflammatory properties, and protects against tissue injury. The human pancreas expresses MFG-E8; however, the role of MFG-E8 in the pancreas remains unclear. We examined the expression of MFG-E8 in the pancreas at baseline and during cerulein-induced acute pancreatitis in mice and determined whether MFG-E8 attenuates the progression of pancreatitis, a serious inflammatory condition that can be life-threatening. We administered cerulein to wild-type (WT) and Mfge8 knockout (KO) mice to induce pancreatitis. Immunoblot analysis showed that MFG-E8 is constitutively expressed in the murine pancreas and is increased in mice with cerulein-induced acute pancreatitis. In situ hybridization revealed that ductal epithelial cells in the mouse pancreas express Mfge8 transcripts at baseline. During pancreatitis, Mfge8 transcripts were abundantly expressed in acinar cells and endothelial cells in addition to ductal epithelial cells. Knocking out Mfge8 in mice exacerbated the severity of cerulein-induced acute pancreatitis and delayed its resolution. In contrast, administration of recombinant MFG-E8 attenuated cerulein-induced acute pancreatitis and promoted repair of pancreatic injury in Mfge8 KO mice. Taken together, our study suggests that MFG-E8 protects the pancreas against inflammatory injury and promotes pancreatic tissue repair. MFG-E8 may represent a novel therapeutic target in acute pancreatitis.
Uptake and Distribution of Administered Bone Marrow Mesenchymal Stem Cell Extracellular Vesicles in Retina
Authors: Mathew Biji , Torres Leianne A. , Gamboa Acha Lorea , Tran Sophie , Liu Alice , Patel Raj , Chennakesavalu Mohansrinivas , Aneesh Anagha , Huang Chun-Chieh , Feinstein Douglas L. , Mehraeen Shafigh , Ravindran Sriram , Roth Steven
Published: March 2021

Cell replacement therapy using mesenchymal (MSC) and other stem cells has been evaluated for diabetic retinopathy and glaucoma. This approach has significant limitations, including few cells integrated, aberrant growth, and surgical complications. Mesenchymal Stem Cell Exosomes/Extracellular Vesicles (MSC EVs), which include exosomes and microvesicles, are an emerging alternative, promoting immunomodulation, repair, and regeneration by mediating MSC’s paracrine effects. For the clinical translation of EV therapy, it is important to determine the cellular destination and time course of EV uptake in the retina following administration. Here, we tested the cellular fate of EVs using in vivo rat retinas, ex vivo retinal explant, and primary retinal cells. Intravitreally administered fluorescent EVs were rapidly cleared from the vitreous. Retinal ganglion cells (RGCs) had maximal EV fluorescence at 14 days post administration, and microglia at 7 days. Both in vivo and in the explant model, most EVs were no deeper than the inner nuclear layer. Retinal astrocytes, microglia, and mixed neurons in vitro endocytosed EVs in a dose-dependent manner. Thus, our results indicate that intravitreal EVs are suited for the treatment of retinal diseases affecting the inner retina. Modification of the EV surface should be considered for maintaining EVs in the vitreous for prolonged delivery.
Microbial Muses: Threads of Our Inner Wisdom
Authors: Erdman Susan E.
Published: March 2021

Spiritual journeys unveil our inner wisdom to help us navigate traumatic life events. Scientific evidence implicates a gut–immune–brain axis in our sense of self, raising the possibility that our microbial partners and hormone oxytocin offer a sense of connectedness and liberate our ancestral archives to sustain us during challenging times.
Evaluating the Effect of a Neonatal Care Bundle for the Prevention of Intraventricular Hemorrhage in Preterm Infants
Authors: Gross Maximilian , Engel Corinna , Trotter Andreas
Published: March 2021

Germinal matrix intraventricular hemorrhage (IVH) remains a severe and common complication in preterm infants. A neonatal care bundle (NCB) was implemented as an in-house guideline at a tertiary neonatal intensive care unit to reduce the incidence of IVH in preterm infants. The NCB was applied either to preterm infants <1250 g birth weight or <30 weeks gestational age or both, and standardized patient positioning, nursing care, and medical procedures within the first week of life. A retrospective cohort study was performed to investigate the effect of the NCB and other known risk factors on the occurrence and severity of IVH. Data from 229 preterm infants were analyzed. The rate of IVH was 26.2% before and 27.1% after implementing the NCB. The NCB was associated neither with reducing the overall rate of IVH (odds ratio (OR) 1.02; 95% confidence interval (CI) 0.57–1.84; p = 0.94) nor with severe IVH (OR 1.0; 95% CI 0.67–1.55; p = 0.92). After adjustment for group differences and other influencing factors, amnion infection syndrome and early intubation were associated with an increased risk for IVH. An NCB focusing on patient positioning, nursing care, and medical interventions had no impact on IVH in preterm infants. Known risk factors for IVH were confirmed.
Curing Behavior of Waterborne Paint Containing Catalyst Encapsulated in Micelle
Authors: Yomo Shuji
Published: March 2021

This research has studied the feasibility of fabricating a catalyst that activates at 80 °C to ensure the curing performance of two-pack isocyanate curable paints, while remaining inactive at 40 °C to ensure storage stability and pot life. The research examined whether the added dibutyl tin dilaurate (DBTL) provided a catalytic function for curing the waterborne paint, which remains almost inactive at 40 °C and activates at 80 °C or higher. It was confirmed that the use of a non-ionic surfactant with a hydrophilic-lipophilic-balance (HLB) of between 13 and 14 resulted in rapid curing at a temperature of 80 °C or higher, thereby demonstrating catalytic properties. The results also show that the viscosity of the paint remained virtually unchanged after exposure for 1 h at 40 °C. This wass presumed to be the result of the DBTL, which was constrained by the micelles up to a temperature of 70 °C, breaking down the micelles at a temperature of 80 °C or higher. It was also confirmed that the catalytic switching properties were not obtained at a lower or higher HLB. It was found that selecting the non-ionic surfactant by HLB can control the activating temperature of the catalytic properties.
A Study on Shape-Dependent Settling of Single Particles with Equal Volume Using Surface Resolved Simulations
Authors: Trunk Robin , Bretl Colin , Thäter Gudrun , Nirschl Hermann , Dorn Márcio , Krause Mathias J.
Published: March 2021

A detailed knowledge of the influence of a particle’s shape on its settling behavior is useful for the prediction and design of separation processes. Models in the available literature usually fit a given function to experimental data. In this work, a constructive and data-driven approach is presented to obtain new drag correlations. To date, the only considered shape parameters are derivatives of the axis lengths and the sphericity. This does not cover all relevant effects, since the process of settling for arbitrarily shaped particles is highly complex. This work extends the list of considered parameters by, e.g., convexity and roundness and evaluates the relevance of each. The aim is to find models describing the drag coefficient and settling velocity, based on this extended set of shape parameters. The data for the investigations are obtained by surface resolved simulations of superellipsoids, applying the homogenized lattice Boltzmann method. To closely study the influence of shape, the particles considered are equal in volume, and therefore cover a range of Reynolds numbers, limited to [9.64, 22.86]. Logistic and polynomial regressions are performed and the quality of the models is investigated with further statistical methods. In addition to the usually studied relation between drag coefficient and Reynolds number, the dependency of the terminal settling velocity on the shape parameters is also investigated. The found models are, with an adjusted coefficient of determination of 0.96 and 0.86, in good agreement with the data, yielding a mean deviation below 5.5% on the training and test dataset.
1,4-Dibromo-2,5-bis(phenylalkoxy)benzene Derivatives: C–Br...π(arene) Versus C–H...Br and Br...Br Interactions in the Solid State
Authors: Manfroni Giacomo , Prescimone Alessandro , Constable Edwin , Housecroft Catherine
Published: March 2021

We have prepared and characterized 1,4-dibromo-2,5-bis(2-phenylethoxy)benzene (1) and 1,4-dibromo-2,5-bis(3-phenylpropoxy)benzene (2). Their single-crystal structures confirm that, at the molecular level, they are similar with the phenylalkoxy chains in extended conformations. However, there are significant differences in packing interactions. The packing in 1 is dominated by C–Br...π(arene) interactions, with each Br located over one C–C bond of the central arene ring of an adjacent molecule. In contrast, the packing of molecules of 2 involves a combination of C–H...Br hydrogen bonds, Br...Br interactions, and arene–arene π-stacking. The single-crystal structures of both orthorhombic and triclinic polymorphs of 1 have been determined and the packing interactions are shown to be essentially identical.
A New Process of Extracting Titanium from Vanadium–Titanium Magnetite
Authors: Li Yandong , Chen Shuangyin , Duan Huamei
Published: March 2021

A new process of extracting titanium from vanadium–titanium magnetite (VTM) in the Panxi area in Sichuan, China is introduced in this work. Various experiments, including reduction–magnetic separation, leaching and hydrolyzing experiments, are carried out. The results show that the optimum conditions for leaching experiments are an acid/slag ratio of 4:1, a leaching temperature of 60 °C, a leaching time of 80 min, and a liquid/solid ratio of 3.2:1. The leaching rate of titanium in Ti-bearing slag is 92.41%. The optimum conditions for hydrolyzing experiments are an H+ concentration of 0.75 g·L−1, hydrolyzing temperature of 100 °C, and hydrolyzing time of 180 min, and the hydrolyzing rate of titanium in acid leaching liquor is 96.80%. After the leaching and hydrolyzing experiments, the recovery rate of titanium from the Ti-bearing slag is 89.45%.
Molecular Dynamics Simulation of the Influence of RDX Internal Defects on Sensitivity
Authors: Yan Pengmin , Zhao Xue , Rui Jiuhou , Zhao Juan , Xu Min , Zhai Lizhe
Published: March 2021

The internal defect is an important factor that could influence the energy and safety properties of energetic materials. RDX samples of two qualities were characterized and simulated to reveal the influence of different defects on sensitivity. The internal defects were characterized with optical microscopy, Raman spectroscopy and microfocus X-ray computed tomography technology. The results show that high-density RDX has fewer defects and a more uniform distribution. Based on the characterization results, defect models with different defect rates and distribution were established. The simulation results show that the models with fewer internal defects lead to shorter N-NO2 maximum bond lengths and greater cohesive energy density (CED). The maximum bond length and CED can be used as the criterion for the relative sensitivity of RDX, and therefore defect models doped with different solvents are established. The results show that the models doped with propylene carbonate and acetone lead to higher sensitivity. This may help to select the solvent to prepare low-sensitivity RDX. The results reported in this paper are aiming at the development of a more convenient and low-cost method for studying the influence of internal defects on the sensitivity of energetic materials.
Anomalous Behavior in the Atomic Structure of Nb3Sn under High Pressure
Authors: Schiesaro Irene , Anzellini Simone , Loria Rita , Torchio Raffaella , Spina Tiziana , Flükiger René , Irifune Tetsuo , Silva Enrico , Meneghini Carlo
Published: March 2021

In the present study, the local atomic structure of a Nb3Sn superconductor sample has been probed by X-ray absorption fine structure (XAFS) as a function of hydrostatic pressure (from ambient up to 26 GPa) using a diamond anvil cell set-up. The analysis of the Nb-K edge extended X-ray absorption fine structure (EXAFS) data was carried out combining standard multi shell structural refinement and reverse Monte Carlo method to provide detailed in situ characterization of the pressure-induced evolution of the Nb local structure in Nb3Sn. The results highlight a complex evolution of Nb chains at the local atomic scale, with a peculiar correlated displacement of Nb–Nb and Nb–Nb–Nb configurations. Such a local effect appears related to anomalies evidenced by X-ray diffraction in other superconductors belonging to the same A15 crystallographic structure.
Exit Pupil Expansion Based on Polarization Volume Grating
Authors: Cui Jingyi , Zhang Yuning
Published: March 2021

In this paper, we demonstrate a waveguide display structure which can realize a large field of view on a two-dimensional plane and a larger exit pupil size at the same time. This waveguide structure has three polarization volume gratings as its coupling elements. We use Zemax to simulate the effect of monochromatic and full-color two-dimensional exit pupil expansion and actually prepared a monochromatic waveguide with a two-dimensional exit pupil expansion structure. For the red, green, and blue light beams, it can achieve a large diffraction angle and can achieve diffraction efficiency of more than 70%. The waveguide structure shown can have an angle of view of 35° in the horizontal direction and 20° in the vertical direction, and an exit pupil of 18 mm long and 17 mm wide was achieved at the same time. As measured, the overall optical efficiency was measured as high as 118.3 cd/m2 per lumen with a transparency of 72% for ambient light.
Radiomic Model Predicts Lymph Node Response to Induction Chemotherapy in Locally Advanced Head and Neck Cancer
Authors: Zhang Michael H. , Cao David , Ginat Daniel T.
Published: March 2021

This study developed a pretreatment CT-based radiomic model of lymph node response to induction chemotherapy in locally advanced head and neck squamous cell carcinoma (HNSCC) patients. This was a single-center retrospective study of patients with locally advanced HPV+ HNSCC. Forty-one enlarged lymph nodes were found from 27 patients on pretreatment CT and were split into 3:1 training and testing cohorts. Ninety-three radiomic features were extracted. A radiomic model and a combined radiomic-clinical model predicting lymph node response to induction chemotherapy were developed using multivariable logistic regression. Median age was 57 years old, and 93% of patients were male. Post-treatment evaluation was 32 days after treatment, with a median reduction in lymph node volume of 66%. A three-feature radiomic model (minimum, skewness, and low gray level run emphasis) and a combined radiomic-clinical model were developed. The combined model performed the best, with AUC = 0.85 on the training cohort and AUC = 0.75 on the testing cohort. A pretreatment CT-based lymph node radiomic signature combined with clinical parameters was able to predict nodal response to induction chemotherapy for patients with locally advanced HNSCC.
Visualizing Glioma Infiltration by the Combination of Multimodality Imaging and Artificial Intelligence, a Systematic Review of the Literature
Authors: d’Este Sabrina Honoré , Nielsen Michael Bachmann , Hansen Adam Espe
Published: March 2021

The aim of this study was to systematically review the literature concerning the integration of multimodality imaging with artificial intelligence methods for visualization of tumor cell infiltration in glioma patients. The review was performed in accordance with the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines. The literature search was conducted in PubMed, Embase, The Cochrane Library and Web of Science and yielded 1304 results. 14 studies were included in the qualitative analysis. The reference standard for tumor infiltration was either histopathology or recurrence on image follow-up. Critical assessment was performed according to the Quality Assessment of Diagnostic Accuracy Studies (QUADAS2). All studies concluded their findings to be of significant value for future clinical practice. Diagnostic test accuracy reached an area under the curve of 0.74–0.91 reported in six studies. There was no consensus with regard to included image modalities, models or training and test strategies. The integration of artificial intelligence with multiparametric imaging shows promise for visualizing tumor cell infiltration in glioma patients. This approach can possibly optimize surgical resection margins and help provide personalized radiotherapy planning.
Auto- versus Cross-Correlation Noise in Periodically Driven Quantum Coherent Conductors
Authors: Moskalets Michael
Published: March 2021

Expressing currents and their fluctuations at the terminals of a multi-probe conductor in terms of the wave functions of carriers injected into the Fermi sea provides new insight into the physics of electric currents. This approach helps us to identify two physically different contributions to shot noise. In the quantum coherent regime, when current is carried by non-overlapping wave packets, the product of current fluctuations in different leads, the cross-correlation noise, is determined solely by the duration of the wave packet. In contrast, the square of the current fluctuations in one lead, the autocorrelation noise, is additionally determined by the coherence of the wave packet, which is associated with the spread of the wave packet in energy. The two contributions can be addressed separately in the weak back-scattering regime, when the autocorrelation noise depends only on the coherence. Analysis of shot noise in terms of these contributions allows us, in particular, to predict that no individual traveling particles with a real wave function, such as Majorana fermions, can be created in the Fermi sea in a clean manner, that is, without accompanying electron–hole pairs.
A Maneuver Evaluation Algorithm for Lane-Change Assistance System
Authors: Jiang Bohan , Li Xiaohui , Zeng Yujun , Liu Daxue
Published: March 2021

This paper proposes a maneuver evaluation approach to enhance driving safety by providing decision aids. Based on the deliberative understanding of environmental semantic information, the proposed algorithm evaluates the risk of candidate driving maneuvers, including aggressive lane-change maneuver, passive lane-change maneuver, lane-change abort maneuver, and lane-keeping maneuver. The effectiveness of the proposed method is validated through various simulation experiments. The experimental results demonstrate that the proposed approach is capable of efficiently evaluating the feasibility and the cost of each candidate driving maneuver. The approach also provides suggestions on how to adjust the speed, and when to initiate a lane-change maneuver.
Accurate and Efficient Evaluation of Bit Error Rate for Dynamic Directional Modulation for Standard Modulation Schemes
Authors: Parrón Josep , Cabrera-Hernandez Edith , Tennant Alan
Published: March 2021

Directional modulation (DM) has been proposed as a technique to enhance physical layer security of wireless transmissions. In DM, the improvement of security is achieved by increasing the transmitted power in such a way that the bit error rate (BER) is degraded in the observation angles out of the desired secure direction. The performance of DM in terms of BER is typically evaluated by transmitting a stream of symbols for every observation angle, but this approach can be time consuming. In this communication, we propose an approach to evaluate, accurately and efficiently, the BER of dynamic DM (DDM) for standard modulation schemes. Several DDM configurations will be tested to illustrate the benefits and limitations of the evaluation method. The proposed approach is also used to present a non-iterative DDM synthesis with restrictions in the BER response.
Hydrogen Dark Fermentation for Degradation of Solid and Liquid Food Waste
Authors: Hovorukha Vira , Havryliuk Olesia , Gladka Galina , Tashyrev Oleksandr , Kalinichenko Antonina , Sporek Monika , Dołhańczuk-Śródka Agnieszka
Published: March 2021

The constant increase in the amount of food waste accumulating in landfills and discharged into the water reservoirs causes environment pollution and threatens human health. Solid and liquid food wastes include fruit, vegetable, and meat residues, alcohol bard, and sewage from various food enterprises. These products contain high concentrations of biodegradable organic compounds and represent an inexpensive and renewable substrate for the hydrogen fermentation. The goal of the work was to study the efficiency of hydrogen obtaining and decomposition of solid and liquid food waste via fermentation by granular microbial preparation (GMP). The application of GMP improved the efficiency of the dark fermentation of food waste. Hydrogen yields reached 102 L/kg of solid waste and 2.3 L/L of liquid waste. The fermentation resulted in the 91-fold reduction in the weight of the solid waste, while the concentration of organics in the liquid waste decreased 3-fold. Our results demonstrated the potential of granular microbial preparations in the production of hydrogen via dark fermentation. Further development of this technology may help to clean up the environment and reduce the reliance on fossil fuels by generating green hydrogen via recycling of household and industrial organic wastes.
Supplying Energy to Vulnerable Segments of the Population: Macro-Financial Risks and Public Welfare
Authors: Smirnova Elena , Szczepańska-Woszczyna Katarzyna , Yessetova Saltanat , Samusenkov Vadim , Rogulin Rodion
Published: March 2021

The purpose of the study is to assess the level of energy supply to the population of the Eastern Europe, Caucasus, and Central Asian (EECCA) countries, taking into account their financial risk and energy efficiency for households as potential socially vulnerable consumers. The research methodology is based on three approaches to determining the energy poverty of the population, as well as the integral index of energy supply to socially vulnerable segments of the population. Based on the results of the three approaches to assessing the level of energy supply to the population of EECCA countries, it has been revealed that its critical indicators are found in Armenia, Georgia, Kyrgyzstan, Moldova, Tajikistan, Turkmenistan, and Ukraine. The multivariate analysis of variance has revealed that, in all EECCA countries, both financial risk and energy efficiency levels have a significant impact. In Azerbaijan, Kazakhstan, and Russia, financial risk has the greatest impact on the level of energy supply to socially vulnerable segments of the population, while in other EECCA countries the energy efficiency factor has the strongest impact. In a number of EECCA countries, households have poor energy supply and require efficient and reliable operation, the introduction of energy-efficient technologies for home maintenance, and the improvement of related programs. The novelty of this study lies in the proposed methodological approach to assessing the supply of energy resources to socially unprotected segments of the population, which makes it possible to determine the impact of financial risk and energy efficiency in EECCA countries.
Evaluation of Inoculated Waste Biological Stabilization Degree by Olfactometric Methods
Authors: Szyłak-Szydłowski Mirosław
Published: March 2021

As a result of compounds’ transformation in the waste biostabilization phases, there is an increase in odor nuisance and health problems among people exposed to odorants. Linking the odor concentration to the degree of waste biostabilization may be an important tool for the assessment of individual technological variants of biostabilization. The study aimed to link the odor emissions to the biostabilization degree in individual process variants that differed in the inoculum. The tests were carried out on inoculated windrows on the waste mechanical-bological treatment open site. Odor concentrations were measured during the entire seven-week process of biostabilization (weeks 1–7) and compared with kinetics parameters of organic compounds’ decomposition. The olfactometric tests showed the necessity of using the preparation to reduce the value of odor concentration. Research proved that the decrease of odor concentration values could be useful to indicate the particular phases of biostabilization. Also, the proposed method provides an opportunity to optimize the process concerning the function related to the low degree of odor nuisance of the technologies, including selection of environmentally safe inoculum. This issue has application values that may result in the implementation of new control systems for waste stabilization bioreactors and the evaluation of applied technological solutions.
Monitoring Urban Expansion and Urban Green Spaces Change in Addis Ababa: Directional and Zonal Analysis Integrated with Landscape Expansion Index
Authors: Woldesemayat Eyasu Markos , Genovese Paolo Vincenzo
Published: March 2021

Addis Ababa, the capital of Ethiopia, is urbanizing very fast. This study aimed to assess urban expansion and Urban Green Spaces (UGS) change in the city from 1989 to 2019. Remote Sensing and Geographical Information System (GIS) and Landscape Expansion Index (LEI) were used to extract Land Use Land Cover (LULC) data, measure urban expansion and UGS change and analyze urban growth pattern in inner zone, outer zone and eight quadrants. The results showed that urban area in the inner zone increased from 3712 ha to 3716 ha (0.1%), and from 3716 ha to 3874 ha (4.2%) and in the first (1989–1999) and second periods (1999–2009), while it decreased from 3874 ha to 3733 ha (3.6%) in the third period (2009–2019), portraying a non-unidirectional trend of change. Conversely, the UGS in the inner zone decreased from 60 ha to 54 ha (10%), and from 54 ha to 38 ha (29.6%) in the first and second periods, while it increased from 38 ha to 53 ha (39.4%) in the third period, reporting spatial tradeoff between the two land cover types. Meanwhile, urban areas in the outer zone increased from 10,729 ha to 15,112 ha (40%), from 15,112 ha to 21,377 ha (41.4%) and from 21,377 ha to 28,176 ha (31.8%) in the first, second and third periods, respectively, representing frontiers of suburbanization. On the other hand, the UGS in the outer zone decreased from 3624 ha to 3171 ha, from 3127 ha to 2555 ha and from 2555 ha to 1879 ha, with an annual rate of decline of 1.25%, 1.8% and 2.6%, respectively, showing increasing trend of UGS destruction for urban construction. Furthermore, the LEI analysis result showed that urban expansion pattern demonstrated largely an outlying growth characterized by differentiation and isolation of patches, whereas the infill and edge expansion pattern were insignificant and fluctuated over 30 years. Furthermore, the directional analysis showed that urban area predominately expanded in SEE,> SSE,> SSW,> SWW,> and NEE directions with varying magnitude in the first, second and third period, but decreased in third period in NWW, < NNW< and NNE directions. In response to such urban growth pattern, the center of gravity of urban area shifted from north to south during the study period, displaying main direction urbanization in recent years. Conclusively, zonal and directional studies are more effective in characterizing the Spatio-temporal dynamics variabilities of urban expansion and UGS change for informed urban planning towards sustainable urban development.