bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinants of Economic Growth in Founder Countries of the Pacific Alliance and the Association of Southeast Asia Nations: Approach from a Systematic Literature Review
Authors: Osorio Barreto Daniel , Cardona Arenas Carlos David , Parra Sánchez José Hernán , Jiménez Varón Cristian Felipe , Cardona Duque Juan Manuel , Mejía Rubio Pedro Pablo
Published: September 2022

El objetivo de este artículo es realizar una aproximación desde una revisión sistemática de la literatura sobre los determinantes del crecimiento económico desde un enfoque de ciclo virtuoso kaldoriano enfocado en los países fundadores de la Alianza del Pacífico y la Asociación de Naciones del Sudeste Asiático a través de bases de datos como Web of Science y Scopus. Se han identificado dos vacíos de conocimiento. El primero corresponde a la falta de estudios que analicen comparativamente los determinantes kaldorianos del crecimiento económico virtuoso; el segundo está relacionado con la escasez de publicaciones relacionadas con la identificación de la convergencia/divergencia entre países y bloques comerciales, que ningún otro trabajo ha estudiado todavía. Como apartado complementario, se realiza un análisis exploratorio de conglomerados el cual reveló que aquellos formados desde 1990 hasta 2018 se han mantenido.
HUBUNGAN ANTARA MANAJEMEN LAYANAN BIMBINGAN DAN KONSELING (BK) DENGAN KARAKTER MANDIRI SISWA DI MTS BANYUAYU KADUR PAMEKASAN
Authors: Syarif Hidayat Ahmad , Buna'i
Published: September 2022

The problems that are the main study in this research, namely: first, is there a relationship between the management of guidance and counseling services with the independent character of students: second, how big is the relationship between the management of guidance and counseling services and the independent character of students. This study uses a quantitative approach with a descriptive type. Sources of data were obtained through questionnaires, interviews, observation, and documentation. The results of this study indicate that: 1. The relationship between the management of guidance and counseling services and the independent character of students at MTS Miftahul Ulum Banyuayu Kadur Pamekasan. 2. The purpose of guidance and counseling services. 2. Values ​​that can build students' independent character. 4. Development program for independent character-based guidance and counseling services. 5. Independent character education in the management of guidance and counseling services. Fostering good relations between teachers and students, between teachers and guardians of students, between teachers and the community or the surrounding environment.
PELAKSANAAN PENILAIAN AUTENTIK DI MADRASAH (STUDI PADA GURU MATEMATIKA DI MADRASAH TSANAWIYAN NEGERI 2 BUKITTINGGI)
Authors: Imamuddin M.
Published: September 2022

The 2013 curriculum emphasizes teachers to carry out authentic assessments. Authentic assessment is an assessment that is actually carried out on students. The implementation of this authentic assessment emphasizes the process rather than the results. It is very important for teachers to carry out authentic assessments in the classroom and outside the classroom to students in order to know the progress of student learning. This study aims to analyze the obstacles and solutions of Madrasah mathematics teachers in the implementation of authentic assessments. This research was conducted at Madrasah Tsanawiyah Negeri 2 Bukittinggi. This study involved 4 Madrasah mathematics teachers, hereinafter referred to as research subjects. Data or information related to obstacles and solutions for implementing authentic assessments were obtained through interviews. The results of this study include: Madrasah mathematics teachers encounter obstacles in planning, implementing, and reporting authentic assessments. These obstacles can be solved with solutions: increasing professional competence, participating in various pieces of training, playing an active role in teacher consultation activities both with one madrasa teacher and with outside madrasa teachers, being active in scientific meetings, and further studies such as through teacher professional education and masters degree.
Latent Profiles of Online Self-Regulated Learning: Relationships with Predicted and Final Course Grades
Authors: Mindrila Diana , Cao Li
Published: September 2022

This study used a combined person- and variable-centered approach to identify self-regulated online learning latent profiles and examine their relationships with the predicted and earned course grades. College students (N=177) at a Southeastern U.S. university responded to the Online Self-Regulated Learning Questionnaire. Exploratory structural equation modeling revealed four self-regulation factors: goal setting, environment management, peer help-seeking, and task strategies. Latent profile analysis yielded four latent profiles: Below Average Self-Regulation (BASR), Average Self-Regulation (ASR), Above Average Self-Regulation (AASR), and Low Peer Help-Seeking (LPHS). Compared with the AASR group, when students anticipated obtaining a higher course grade, they were less likely to engage in peer help-seeking and task strategies and more likely to adopt the LPHS self-regulation profile. Relating to LPHS, membership to all other groups predicted significantly lower course grades. AASR and LPHS predicted their performance most accurately, with non-significant differences between the predicted and the final course grades.
Emergency Online Learning: The Effects of Interactional, Motivational, Self-Regulatory, and Situational Factors on Learning Outcomes and Continuation Intentions
Authors: Lei Jun , Lin Teng
Published: September 2022

This study investigated the effects of interactional, motivational, self-regulatory, and situational factors on university students’ online learning outcomes and continuation intentions during the COVID-19 pandemic. Data were collected from 255 students taking a business course at a university in southern China. Hierarchical multiple regression analyses revealed that while family financial hardship caused by COVID-19 was a marginally significant negative predictor of students’ learning outcomes, learner–content interaction; instructors’ provision of e-resources, course planning, and organisation; and students’ intrinsic goal orientation and meta-cognitive self-regulation were significant positive predictors with the latter two sets of predictors mediating the effects of learner–instructor and learner–learner interactions, respectively. Multinominal logistic regression analyses showed that learner–instructor interaction, learner–content interaction, and private learning space were significant positive predictors of students’ intentions to continue with online learning, but learner–learner interaction was a significant negative predictor. These findings point to the differential effects of various types of interactional and situational factors on learning outcomes and continuation intentions, and the instructor- and learner-level factors that mediate the effects of learner–instructor and learner–learner interactions on learning outcomes. They contribute to our understandings of emergency online learning and provide implications for facilitating it.
Waste streams as current sources of persistent organic pollutants and organophosphate esters in Africa - a critical review
Authors: Akinrinade Olumide Emmanuel , Stubbings William A.
Published: September 2022

Per- and polyfluoroalkyl substances, chlorinated paraffins, brominated flame retardants, polychlorinated biphenyls and mirex are regulated under the United Nations Environment Programme’s (UNEP’s) Stockholm Convention on Persistent Organic Pollutants (POPs) intended for the eradication of hazardous contaminants in the environment. There is also a major concern for organophosphate esters and specific alternative or novel brominated flame retardants. To date, no evidence exists that major producers of these chemicals occur on the African continent. They are understood to find their way into African environments through the import of commercial products, in particular products with second-hand value and short lifespans, which may enter waste streams in a relatively shorter period. To further understand the current levels of these selected contaminants in African waste streams, existing documents capturing various African waste stream compartments for the above outlined targeted contaminants were gathered from an exhaustive literature review. Key factors influencing the transfer of contaminants from waste or elevated concentrations of contaminants in African waste streams are associated with the nature and/or sources of contaminants, volume of contaminants or waste in relation to the capacity of treatment plants/landfills, condition or age of treatment plants/landfill geomembrane liner, model adopted for contaminants removal and treatment procedures for collected sludges or leachates. Evidence from the selected studies indicates substantial POP contamination in African landfills and dumpsites, wastewater effluents/sludge and human/biological samples around dumpsites and landfills. Unfortunately, the continent has inadequate infrastructural capacity to adequately handle POP in the waste streams. This review provides recommendations and suggestions for future studies.
„Mindig meg kell ezt beszélni, ha be vagy zárva, ha nem” : Családi kommunikációs mintázatok koronavírus-járvány idején
Authors: Incze-Borbándi Johanna , Pólya Tamás
Published: September 2022

Pilot kutatásunk a családi kommunikáció változását vizsgálta a koronavírus-járvány miatt elrendelt első lezárás (2020) idején. Négy, gyermekes magyar párral készítettünk interjút arról, hogy együtt élő családtagjaikkal változott-e a kommunikáció minősége, intenzitása, s hogyan oldották fel a vitás kérdéseket a házimunka és gyermeknevelés kapcsán. Eredményeink: a vírushelyzet nem alapjaiban változtatta meg a családi kommunikációs mintázatokat, csak felerősített létező folyamatokat és helyzeteket. Az összezártság növelte az interakciók számát, de nem javította az interakció minőségét (pl. konfliktuskezelés); erősítette a családi összetartozástudatot (a vírus mint közös ellenség), de az egyenlőtlen genderszerepeket is (az oktatás megszervezése a nőkre hárult). Szembetűnő, hogy míg a férfiak alig számoltak be kommunikációs problémákról, addig a nők jóval több gondot és feszültségforrást említettek.
Deep Diversity: Extensive Variation in the Components of Complex Visual Systems across Animals
Authors: Vöcking Oliver , Macias-Muñoz Aide , Jaeger Stuart , Oakley Todd H
Published: September 2022

Understanding the molecular underpinnings of the evolution of complex (multi-part) systems is a fundamental topic in biology. One unanswered question is the extent to which similar or different genes and regulatory interactions underlie similar complex systems across species. Animal eyes and phototransduction (light detection) are outstanding systems to investigate this question because some of the genetics underlying these traits are well-characterized in model organisms. However, comparative studies using non-model organisms are also necessary to understand the diversity and evolution of these traits. Here, we compare the characteristics of photoreceptor cells, opsins, and phototransduction cascades in diverse taxa, with particular focus on cnidarians. In contrast to the common theme of deep homology, whereby similar traits develop mainly using homologous genes, comparisons of visual systems - especially in non-model organisms - are beginning to highlight a “deep diversity” of underlying components, illustrating how variation can underlie similar complex systems across taxa. Although using candidate genes from model organisms across diversity was a good starting point to understand the evolution of complex systems, unbiased genome-wide comparisons and subsequent functional validation will be necessary to uncover unique genes that comprise complex systems of non-model groups to better understand biodiversity and its evolution.
Genetic Relationships and Signatures of Adaptation to the Climatic Conditions in Populations of Apis cerana Based on the Polymorphism of the Gene Vitellogenin
Authors: Ilyasov Rustem Abuzarovich , Rašić Slađan B. , Takahashi Junichi , Danilenko Valery Nikolaevich , Proshchalykin Maxim Yurevich , Lelej Arkady Stepanovich , Sattarov Vener Nurullovich , Thai Pham Hong , Raffiudin Rika , Kwon Hyung Wook
Published: September 2022

Apis cerana and Apis mellifera, are very important honey species for agriculture in Asian countries. In recent decades, A. cerana populations have sharply declined in all Asian countries as a result of Sacbrood Virus infection and have now recovered to their original size. It can change the genetic structure of local populations of A. cerana. We used the nuclear gene Vitellogenin VG to assess the genetic structure of local populations of A. cerana and the signature of adaptive selection. We performed a population genetic analysis of the honey bees A. cerana from South Korea in comparison with A. cerana samples from Russia, Japan, Nepal, and China. The sequences of the gene VG of a closely related honey bee species, A. mellifera, from India and Poland were used as outgroup samples. A comparative analysis of northern and southern A. cerana populations was performed. The signatures of positive adaptive selection were found in the local population of A. cerana. We performed the Tajima's neutrality D test for A. cerana populations from different local populations based on the gene VG exon sequences. All A. cerana populations showed signs of population size expansion following the possible recent decline in population sizes. The local populations of A. c. koreana were subdivided according to their geographical distribution into southern, northern, and central Korean clusters. The gene VG exon sequences can be used as informative markers for monitoring the changes in genetic structure and adaptation to the environment processes in A. cerana populations.
Characterization Attempt on Logos in Heidegger
Authors: GÜNAYDIN İbrahim
Published: September 2022

This study is an attempt to characterize the word logos. In this research process, Heidegger’s phenomenological method will be taken into account as much as possible. Explanations on the logos in the “Second Chapter” of Heidegger’s “Preface” of Being and Time, published in 1927, will form the scope of the study. The study will present its research in three stages. In the first of these stages, the following subjects will be investigated: how Heidegger handles the word logos in his book Being and Time, what method he follows here, and what are the main theses on which this method is based. In the second stage, the terms “alêtheia”, “signifier”, “signified”, “phenomenon”, “appearance” will be discussed in Heidegger’s phenomenology understanding. As a matter of fact, each of these are terms with which this study directly or indirectly relates. In addition, what this study has done is essentially a phenomenological exposition of the logos. Therefore, this exposition will also be included in the scope of the study. The words “explain” and “interpret” will be used to aid this exposition. In the third stage, “Recharacterization of the Logos”, the main issue of the study, the word logos, will be discussed and it will be questioned how it can be expressed in accordance with its original form.
STUDENTS’ PERCEPTION OF CULTURAL VALUES IN “TRAVEL” POEM THROUGH YOUTUBE
Authors: Pudjiati Danti , Zuriyati
Published: September 2022

Since the popularity of YouTube as one of the sources to learn language especially English in digital era, students in tertiary education nowadays tend to appreciate a poem through this platform. The research about appreciating the cultural values of English poem is still far on the ground. Therefore, this study focuses to find out the students perception of cultural values in “Travel” as a classical poem by Robert Stevenson. The qualitative method of interview and online survey is conducted to obtain the students’ views of cultural values proposed by Schwart. The result revealed that they stated stimulation, self-direction, conformity and tradition as the cultures values expressed in that poem. However students selected youTube as the most preference way in appreciating the poem due to its attractive visual and vast imagination.
Comparison of Methods of Affect Transition Analysis: An Example of SimInClass Dataset
Authors: ÇAĞLAR ÖZHAN Şeyma , ALTUN Arif
Published: September 2022

Studies of emotional-cognitive sequences are the growing body of research area in educational context. These studies focus on how emotions change during the learning-teaching process due to their dynamic nature. In affect transition studies, the change of emotion, depending on the event and time, is usually analyzed by using (a) lag sequential analysis (LSA), (b) L metric, (c) L* metric, and (d) Yule's Q metric. Yet, various methodological criticisms exist in the literature while utilizing these sequential analysis methods. In this study, it is aimed to comparatively examine lag analysis, L metric, L* metric, and Yule’s Q in terms of proportion of invalid values, maximum transition metrics, minimum transition metrics, and analysis results. For this reason, the emotional states of the fifteen prospective teachers were collected and their emotions were labeled every 0.5 seconds with EEG (Electroencephalogram), GSR (Galvanic Skin Response), and Microsoft Kinect in a teacher training simulator (SimInClass). The dataset contained 17570 emotions, and the data were analyzed by utilizing lag analysis, L, L* and Yule's Q. The results showed that LSA had yielded the most proportion of invalid results. In addition, it was observed that the number of invalid values increased as the segment length became shorter in all analysis methods. When the maximum and minimum transition metric values were examined, it was found that as the sequence length increased in L and L* analyses, the value of the metrics approached 1, which is the largest value they can reach. However, it was noted that the lag analysis maximum-minimum transition metrics fluctuate independently from the sequence length. It was concluded that there were differences in the analysis results produced by the four sequential analysis methods with the same functions. It was thought that this situation might be due to the different invalid results produced by the analyses. When the results were compared with the studies in the literature, it was thought that it would be beneficial to pay attention to the nature of the data (emotional or behavioral), the data type (singe modality or multimodal modality), the amount of data (short sequences or long sequences), the environment in which the dataset was created (computer-based or not), and the sampling rate (automated data collection tool or observation) when choosing sequential analysis methods.
Improving the estimation of thermospheric neutral density via two-step assimilation of in-situ neutral density into a numerical model
Authors: Corbin Armin , Kusche Jürgen
Published: September 2022

Neutral thermospheric density is an essential quantity required for precise orbit determination of satellites, collision avoidance of satellites, re-entry prediction of satellites or space debris, and satellite lifetime assessments. Empirical models of the thermosphere fail to provide sufficient estimates of neutral thermospheric density along the orbits of satellites by reason of approximations, assumptions and a limited temporal resolution. At high solar activity these estimates can be off by 70% when comparing to observations at 12 hourly averages. In recent decades, neutral density is regularly observed with satellite accelerometers on board of low Earth orbiting satellites like CHAMP, GOCE, GRACE, GRACE-FO, or Swarm. When assimilating such along-track information into global models of thermosphere-ionosphere dynamics, it has been often observed that only a very local subdomain of the model grid around the satellite’s position is updated. To extend the impact to the entire model domain we suggest a new two-step approach: We use accelerometer derived neutral densities from the CHAMP mission in a first step to calibrate an empirical thermosphere density model (NRLMSIS 2.0). In a second step, we assimilate—for the first time—densities predicted for a regular three dimensional grid into the TIE-GCM (Thermosphere Ionosphere Electrodynamics General Circulation Model).Data assimilation is performed using the Local Error-Subspace Transform Kalman Filter provided by the Parallel Data Assimilation Framework (PDAF). We test the new approach using a two-week-long period containing the 5 April 2010 Geomagnetic storm. Accelerometer derived neutral densities from the GRACE mission are used for additional evaluation. We demonstrate that the two-step approach globally improves the simulation of thermospheric density. We could significantly improve the density prediction for CHAMP and GRACE. In fact, the offset between the accelerometer derived densities and the model prediction is reduced by 45% for CHAMP and 20% for GRACE when applying the two-step approach. The implication is that our approach allows one to much better ’transplant’ the precise CHAMP thermospheric density measurements to satellites flying at a similar altitude.
Evaluation of different adjuvant formulations of trivalent Foot and Mouth Disease vaccine in cattle
Authors: Ayele Getu , Getachew Belayneh , Bari Fufa Dawo , Bayissa Berecha , Muluneh Ayelech , Abayneh Takele , Gelaye Esayas , Edao Bedaso Mammo
Published: September 2022

Background
Foot-and-mouth disease is globally one of the most economically important viral diseases of cloven-hoofed animals that can be controlled by different strategies, where vaccination plays an important role. Selection of the adjuvants,that added to the vaccine is crucial in ensuring the protective effect of the vaccine. Aluminum hydroxide gel and saponin (AS) is widely used adjuvant, with its poor immune response in FMD vaccine. The present study was undertaken to evaluate different ingredients of adjuvants for inactivated trivalent (A, O and SAT 2) FMD vaccine and to demonstrate the effect of booster dose in cattle.
Results
Cattle were grouped into five; four experimental and one control, with six animals in each group and immunized with trivalent vaccine with various formulations of adjuvants. Immune response was measured using Solid Phase Competitive Enzyme Linked Immune Sorbent Assay (SPCE). The antibody level in cattle immunised with a vaccine formulation containing a mixture of aluminum hydroxide gel and saponin (AS) were significantly lower than AS boosted group for the three serotypes (p < 0.05, t. test), which directs the need for booster dose. Whereas the antibody response in the AS + oil group was higher followed by oil alone, AS boosted and AS at 95% CI.
Conclusion
The findings of this study could suggest that oil based and AS with oil could replace the conventional aluminum hydroxide gel and saponin adjuvants in FMD vaccine preparations. On different note, challenge test was not successful in this study indicating the need for further research on the virus infectivity.
Validation of the Fear of COVID-19 Scale and its relationship with preventive behavior and anxiety disorders in Pakistan
Authors: Mahmood Qaisar Khalid , Sohail Malik Muhammad , Akbar Muhammad Siddique , Qureshi Waheed Ahmad , Zakar Rubeena , Fischer Florian
Published: September 2022

Background: COVID-19 has caused a huge wave of fear across many nations around the globe. From a theoretical point of view, it is argued that fear induced by an imminent threat leads people to take defensive measures and at the same time creates psychiatric disorders. We conducted this study to validate the Urdu (national language in Pakistan) version of the Fear of COVID-19 Scale in the Pakistani context. We also examined the relationship between fear and 1) preventive behavior and 2) anxiety disorders among the general population.
Methods: We collected data from 2005 respondents across the country and confirmed the validity of the Urdu version of this scale. Structural analysis uncovered that fear of COVID-19 significantly predicts preventive behavior and anxiety disorder among respondents.
Results: This study confirms that fear of COVID-19 has aroused mixed feelings among the population in Pakistan. Fear of contracting COVID-19 has induced the masses to take preventive measures, while at the same time, it has also produced feelings of anxiety.
Conclusions: Previous research in this field also reported that fear of COVID-19 contributed significantly to mental health problems. Therefore, health authorities and governments must take measures to ensure mental health through psychosocial interventions.
Suitability of continuous glucose monitoring in healthy subjects to detect effects of meal sequences and nutritional content of meals on postprandial glycemic responses
Authors: Waldenmaier Delia , Buck Sina , Pleus Stefan , Beltzer Anne , Schauer Sebastian , Link Manuela , Zschornack Eva , Jendrike Nina , Haug Cornelia , Freckmann Guido
Published: September 2022

Background
Continuous glucose monitoring (CGM) systems have initially been developed for diabetes patients but are also increasingly used by healthy people in order to monitor individual eating behaviors and the glucose responses to different foods, e.g. to support weight loss. The aim of the study was to assess the suitability of this technology to detect effects of meal sequences and nutritional content of meals on postprandial glycemic responses. In addition, the effect of meal sequences on the subsequent eating behavior was evaluated.
Subjects/Methods
On two consecutive days, 36 participants without diabetes received standardized test meals (TM) for breakfast and lunch, as well as a free-choice dinner. Both TM contained equal amounts of carbohydrates with different absorption characteristics and differing fat and protein content. Participants consumed TM “fast” for breakfast and “slow” for lunch on one day, and in reverse order on the other day. Dinner was selected from a buffet; meal content and amount were free-choice. Participants rated their feeling of satiety directly before dinner intake. Glucose profiles were assessed with a CGM device.
Results
CGM was able to distinguish postprandial glucose responses according to the nutritional content of the TM. When TM were consumed for lunch, median glucose increase was higher than when consumed for breakfast (TM “fast”: 72.7 mg/dL vs. 56.5 mg/dL; TM “slow”: 38.3 mg/dL; vs. 22.1 mg/dL). Satiety before dinner was lower and energy intake for dinner was higher after TM “fast” for lunch than after TM “slow” for lunch (5 058.3 ± 1 787.8 kJ vs. 4 429.8 ± 1 205.4 kJ).
Conclusions
Data collected in this evaluation with the use of CGM firstly supports its use under everyday life conditions in people without diabetes and secondly could contribute to identify beneficial dietary patterns that may be considered in the management and prevention of metabolic disorders.
Characterization of functioning in breast cancer survivors: an interpretive descriptive analysis study based on the international classification of functioning, disability, and health (ICF) and the Item-Perspective Classification Framework
Authors: Jamshidi Farkhondeh , Farzad Maryam , MacDermid Joy , Hosseini Seyed Ali , Habibi Mojtaba , Alizadehasl Azin
Published: September 2022

Purpose

Breast cancer survivors experience a range of disabilities compromise their independent function. This study aimed to examine their perspectives and experts on their functioning and interpret concepts with the international classification of functioning, disability, and health (ICF) and the Item-Perspective Classification Framework (IPF).

Methods

Interpretive descriptive methods were used with in-depth interviewing with 16 breast cancer survivors and 22 experts using a semi-structured interview guide. The interviews were recorded, transcribed, and qualitatively analyzed using thematic analysis. The extracted data were linked to the ICF Core Set for Breast cancer and were interpreted by the IPF.

Results

Four main themes emerged to define the functioning of BC survivors: body functioning, physical functioning, social functioning, and mental functioning. Three other factors were also categorized as modifiers of functioning personal, emotional, and environmental. The 592 extracted meaningful concepts were linked to 38 (47%) categories from the ICF: 16 Body Functions, 14 Activities and Participation, and 8 Environmental Factors. The IPF classified all the extracted concepts, and most rational appraisals fell in the biological (B) domain. The concepts that required emotional appraisal were classified in Psychology (P).

Conclusion

Psychological and emotional factors were pivotal in defining functioning in patients with BC.
The Role of Linc00467/TRAF5 in Promoting the Malignant Progression of Prostate Cancer and its Mechanism
Authors: Wang Yibing , Zhang Xiali , Wu Lidong , Fu Bin , Wang Gongxian , Luo Zhiqiang , Zeng Tao , Luo Jun
Published: September 2022

Background
Prostate cancer (PCa) is a commonly occurring cancer in the prostate. However, its pathogenesis is complex and remains largely unknown. This study aims to uncover the biological role of Linc00467/TRAF5 in influencing the progression of PCa and to provide novel directions for clinical treatment of PCa.
Methods
Linc00467 and TRAF5 were screened from PIA through chip detection in our previous study. Linc00467 and TRAF5 expression was verified using RT-qPCR in PC3, DU145, and normal human prostate epithelial cell line (HPrEC). Clinical specimens were collected to measure the expression of Linc00467 and TRAF5 in normal prostate tissue, PIA tissue, and PCa tissue using RT-qPCR. To further elucidate the regulatory effects of Linc00467 on TRAF5, siLinc00467 (SH4) was transfected into PCa cell lines (PC3 and DU145), and the expression of TRAF5 was detected by Western-blot. To study the impact of Linc00467 and TRAF5 on the biological behavior of PCa cells, we transfected siLinc00467 (SH4), overexpressed TRAF5 plasmid (Ov-TRAF5), and overexpressed siLinc00467 + TRAF5 plasmid into PC3 and DU145 cells, respectively. Next, we performed specific assays (MTT assay, scarification test, Transwell, Tunel, and flow cytometry) to analyze the effects of Linc00467 and TRAF5 on proliferation, migration, invasion, and apoptosis of PCa cells (PC3 and DU145). We also utilized a tumor-bearing nude mice model to understand the effects of Linc00467 and TRAF5 on tumor growth.
Results
The experimental results demonstrate that Linc00467 is highly expressed in PCa cell lines (PC3 and DU145), while the expression of TRAF5 is low. We found a similar pattern in clinical specimens (PIA and PCa tissues) where in Linc00467 was highly expressed and TRAF5 was downregulated. Inhibiting Linc00467 can promote TRAF5 expression, significantly reducing the proliferation, migration, and invasion of PCa cells (PC3 and DU145) and promoting apoptosis. The experiment on tumor-bearing nude mice showed that Linc00467 inhibition and overexpressed TRAF5 could inhibit tumor growth.
Conclusion
Our study suggests that Linc00467 is a tumor-promoting gene in PCa, while TRAF5 is a tumor suppressor gene. Furthermore, Linc00467 has a regulatory effect on TRAF5. The tumor-promoting effect of Linc00467 may be exerted by regulating TRAF5, but its specific mechanism needs to be explored further.
Revisiting CO2 Emissions and Economic Growth in 10 Asian Countries: a Quantile-on-Quantile Approach
Authors: Chang Tsangyao , Chang Yu-Cheng , Chen Sheng-Tung , Wang Mei-Chih
Published: September 2022

This study applies a Quantile-on-Quantile model to investigate the emissions-economic growth relationship. Data from ten Asian countries for period of 1969–2019 is used. Both real GDP per capita and CO2emissions data are used in this study. Empirical results from our Quantile-on-Quantile model show that the relationship between CO2emissions and GDP varies across quantiles. Our findings indicate that most countries face a transformation of energy consumption structure, except for Japan and Singapore. Our results have important policy implications for the study countries.
Eye-mimicked neural network composed of photosensitive neural spheroids with human photoreceptors
Authors: Park Byeongho , Bang Seokyoung , Hwang Kyeong Seob , Cha Yeon Kyung , Kwak Jisung , Tran Na Ly , Kim Hyo-Suk , Park Subeen , Oh Seung Ja , Im Maesoon , Ryu Yong-Sang , Chung Sooyoung , Kim Jongbaeg , Park Tai Hyun , Song Hyun Seok , Kim Hong Nam , Kim Jae Hun
Published: September 2022

An in vitro model of an eye-to-brain circuit, composed of human photoreceptors that are the short-wavelength opsins and rhodopsins, was created. Two types of photosensitive neural spheroids were transfected for selective reaction under bluish-purple and green lights. These samples were applied to two devices with intact neuron and neural-spheroid to study the interaction. By photostimulation, the photosensitive spheroid initiated photoactivation and phototransduction, and the signal generated from its body was transmitted to adjacent neural networks. Specifically, the signal traveled two millimeters through the axon bundle in the narrow gap from the photosensitive spheroid to the intact spheroid as the eye-to-brain model including optic nerves. The whole process with the photosensitive spheroid was monitored by calcium assay fluorescence images and analyzed by several immunostaining imaging methods. The results of this study can be applied to examine and understand vision restoration and novel photosensitive biological systems with spectral sensitivity.
`Secretory IgA and course of COVID-19 in patients receiving a bacteria-based immunostimulant agent in addition to background therapy
Authors: Kostinov Michail , Svitich Oksana , Chuchalin Alexander , Osipcov Valerij , Khromova Ekaterina , Abramova Natal'ya , Tatevosov Vitalij , Vlasenko Anna , Gajnitdinova Viliya , Pakhomov Dmirrij , Mashilov Kirill , Ospel'nikova Tat'yana , Mikhailova Natal'ya , Polishchuk Valentina , Kurbatova Ekaterina , Kostinova Aristitsa
Published: September 2022

Scientific Relevance: Mucosal immunity plays a major role not only in the prevention but probably also in the outcome of COVID-19. An enhanced production of secretory immunoglobulin A (sIgA) might contribute to the activation of the immune response mechanisms.
Study Objective: To assess the levels of sIgA produced by epithelial cells in the nasal and pharyngeal mucosa and those measured in salivary gland secretions and to study the course of COVID-19 following the intranasal or subcutaneous administration of a bacteria-based immunostimulant agent.
Materials and Methods: This study included 69 patients, aged between 18 and 60, who had moderate COVID-19 infection. They were divided into two groups: Group 1 (control group) included 39 patients who received only background therapy, and Group 2 was made up of 30 patients who received background therapy in combination with the Immunovac VP4 vaccine, a bacteria-based immunostimulant agent, which was given for 11 days starting from the day of admission to hospital. The levels of sIgA were measured by ELISA in nasal epithelial swabs, pharyngeal swabs, and salivary gland secretions at baseline and on days 14 and 30.
Results: The convalescence phase of moderate COVID-19 was associated with a decrease in sIgA levels in nasal swabs, persistently high sIgA levels in salivary gland secretions, and no changes in pharyngeal swabs with the levels similar to those in healthy subjects. The addition of an immunostimulant agent to combination therapy for patients with COVID-19 stimulates the production of sIgA in the nasal and pharyngeal compartments, reduces C-reactive protein (CRP) levels and shortens the duration of fever and the length of hospital stay.
Conclusion: Using an immunomodulatory agent containing bacterial ligands in therapy for COVID-19 patients enhances the production of sIgA in the nasal and pharyngeal compartments and improves the course of the disease.
Simulating widespread extreme rainfall events over the Drakensberg with WRF and MPAS models.
Authors: TAKONG Ridick Roland , Abiodun Babatunde Joseph
Published: September 2022

This study investigates the characteristics of widespread extreme rainfall events (WERE) over the Drakensberg with the aid of observation, reanalysis, and simulation data during the period 1987–2016. WERE event over the DMR was defined as a rainfall event during which at least 40% of the grid points over the DMR experienced at least 95% percentile of daily rainfall at the respective grid points. The simulations were performed using the Weather Research and Forecasting (WRF) model and the Model for Prediction Across Scales (MPAS). The capacity of the WRF and MPASS models to represent past characteristics of extreme precipitation over the DMR was evaluated against five observation datasets and the forcing reanalysis data. Precipitation characteristics were represented with four precipitation indices. Both models (MPAS and WRF) simulate realistic rainfall characteristics over Southern Africa, especially over South Africa and DMR. For all the precipitation indices, the models capture the west-east precipitation gradient over South Africa and reproduce the local precipitation maxima over the DMR as well as along the south and southeast coasts of South Africa. Nevertheless, there are notable differences in the performance of the models. While MPAS performs better than WRF in some cases, WRF performs better than MPAS in other cases. All the observation datasets agree that WERE mostly occurs in three seasons over DMR and does not occur every year. However, there are substantial disagreements among the datasets regarding the climatology and annual frequency of WERE. Self-organizing map analysis of grid points where extreme rainfall occurred during WERE events shows that there are 5 major spatial patterns of strong rainfall areas during WERE events over the Drakensberg. The patterns are generally associated with frontal systems, tropical temperate troughs, and ridging highs. Patterns of strong rainfall areas during WERE events identified in this study could help in the management of extreme rainfall-related disasters around the Drakensberg.
Research on a cushioning structure for the midsoles of sports shoes based on the three-dimensional pore structure of loofahs
Authors: Zhang Zonghai , Zuo Jingwu
Published: September 2022

A study based on the three-dimensional structural properties of loofahs was carried out to model and analyse the vibration damping characteristics of reinforced composite loofah materials and structures. The structural model was tested for Young's modulus compression by using finite element techniques. Based on the results of the study, a lightweight cushioning structure based on a reinforced composite loofah with polygonal pores was developed and used as a midsole cushioning module for running shoes. The structure was then subjected to dynamic shock vibrations, compression, vibration damping and loss factor, fatigue testing and compression testing. The results of the tests showed that the midsole achieved an ideal balance of weight and mechanical performance and was an excellent cushioning structure with high durability.
Marketing-induced demand generation and the evolution of market concentration
Authors: Chudziak Szymon
Published: September 2022

The current standard in agent-based economic modelling is effectively to conform to the technological view of the firm, wherein marginal costs play the central role. This is in contrast with the majority of theoretical research on business entities. The impact of marketing and demand-generation capabilities of firms has not been considered in quantitative theoretical frameworks. Moreover, competition and evolution of market shares has been most often modelled by the means of replicator dynamics. However, in its canonical form it is backward-looking, unaffected by any current variables; in a converse situation, the problem of ensuring mutual consistency of market shares changes arises. An alternative competition framework is proposed. An agent-based model is developed, in which firms are modelled as behavioural, contractual and procedural entities and their marketing affects the growth rate of demand. The proposed method of modelling firms' competition allows for representing markets with stationary, increasing, or decreasing concentration, with or without market leaders, and those composed of firms of similar size but transitioning to new stationary states of market concentration. It is demonstrated that the evolution of market concentration and the pace of marketing-enhanced demand growth depends on three factors: the size of possible market shares gains and losses per period, whether firms’ competitive power is related to their market share or not, and on the initial market composition. Moreover, enhancing demand growth is possible even in settings that are computational equivalents of perfectly competitive markets.
JEL codes: D40, D90, L11, L22, M31
Phthalates and Heavy Metals in Sewer and Outlet Stream in a part of Lagos Southwest Nigeria
Authors: Onipede Olumayowa Joshua , Chigbundu Chijioke Emmanuel , Onifade Olayinka Omoniyi , Adewuyi Olufemi Gregory
Published: September 2022

Contaminants and pollutants impact on the availability of clean water for the human population is huge as clean water is increasingly scarce for human consumption on earth most especially in major cities of the world; As water is used they are heavily contaminated and hence there is the need to examine the persistent pollutants most especially phthalates and heavy metals in wastewater and outlet stream. This research examined the level of dimethyl phthalate (DMP), diethyl phthalate (DEP), dibutyl phthalate (DBP), and heavy metals viz; Pb, Cr, Cd, As and Hg in the sewer and outlet stream in a part of Lagos, Nigeria. DMP ranged from 0.0070 ± 0.036 to 0.0278 ± 0.324, DEP ranged from 0.0367 ± 0.204 to 0.0526 ± 0.496, and DBP ranged from 0.0406 ± 0.241 to 0.1472 ± 1.667 µg/mL, lead ranged from 0.117 ± 0.024 to 0.157 ± 0.048, chromium ranged from nd (not detected) to 0.319 ± 0.245, cadmium ranged from 0.004 ± 0.002 to 0.063 ± 0.021, arsenic ranged from 0.002 ± 0.001 to 0.021 ± 0.006, and mercury ranged from nd to 0.007 ± 0.001 µg/mL. The concentration of lead in this study was higher than the WHO recommended value of 0.1 mg/L in surface water. This research established that phthalates and heavy metals were released into the wastewater from the immediate environment. We suggest that the sewer treatment of the wastewater be reviewed and improved to eliminate the contaminants in the wastewater.
WITHDRAWN: Improving the Performance of Diagnosing Chronic obstructive Lung Disease Using Outlier Detection with Decision Tree Algorithm
Authors: Balamurugan K S , Chakrabarti Prasun , Chakrabarti Tulika , Gupta Amit , Elngar Ahmed A. , Nami Mohammad , Ravi Vinayakumar , Rajchakit Grienggrai , Akbar M Ali
Published: September 2022

Chronic Obstructive Lung Disease (COLD) is a continual inflammatory lung disorder that causes blocked airflow from the lungs. It is also called Chronic Obstructive Pulmonary Disease (COPD.) It is responsible for a variety of different conditions such as chronic bronchitis (breathing passages in the lungs) and emphysema (air sacs in the lungs). The right diagnosis of sickness is one of the foremost important complications in medicine. Hence, computerized analysis of diagnosing COPD has been developed to decrease the time and reduce the demise rate. A classification algorithm is one of the computerized techniques which is utilized for the diagnosis of COPD. In this research work, we proposed a hybrid algorithm called ODWDT (Outlier Detection with Decision Tree) algorithm. It comprises two phases; in the first phase, the thoracic data set is preprocessed using Inter Quartile Range (IQR). In the second phase, the COPD patients are diagnosed and classified by using the J48 decision tree classifier. The thoracic surgery dataset can be used to assess samples that might be risk factors for lung cancer which is taken from the UCI Machine learning repository. Experimental results showed that the proposed method achieved 95% classification accuracyin diagnosing chronic obstructive lung disease patients. The outcome of this research work is to diagnose patients with better classification accuracy so that we can be planned for the next treatment. Results proved that the proposed ODWDT algorithm performs better in the diagnosis of COPD.
A socio-physics based hybrid metaheuristic for solving complex non-convex constrained optimization problems
Authors: Kale Ishaan R , Kulkarni Anand J , Mezura-Montes Efren
Published: September 2022

Several Artificial Intelligence based heuristic and metaheuristic algorithms have been developed so far. These algorithms have shown their superiority towards solving complex problems from different domains. However, it is necessary to critically validate these algorithms for solving real-world constrained optimization problems. The search behavior in those problems is different as it involves large number of linear, nonlinear and non-convex type equality and inequality constraints. In this work a 57 real-world constrained optimization problems test suite is solved using two constrained metaheuristic algorithms originated from a socio-based Cohort Intelligence (CI) algorithm. The first CI-based algorithm incorporates a self-adaptive penalty function approach i.e., CI-SAPF. The second algorithm combines CI-SAPF with the intrinsic properties of the physics-based Colliding Bodies Optimization (CBO) referred to CI-SAPF-CBO. The results obtained from CI-SAPF and CI-SAPF-CBO are compared with other constrained optimization algorithms such as IUDE, ϵMAg-ES and iLSHADE𝜖. The superiority of the proposed algorithms is discussed in details followed by future directions to evolve the constrained handling techniques.
What influences newly graduated registered nurses’ intention to leave the nursing profession? An integrative review
Authors: Lyu Xiao-Chen , Huang Shuang-Shuang , Ye Xiao-Ming , Zhang Lu-Yu , Zhang Peng , Wang Ya-Juan
Published: September 2022

Background
Newly graduated RNs leaving the nursing profession in the early stages of their career have enormous financial and time implications for nursing organizations and affect the quality of nursing care.
Methods
An electronic search was conducted for English articles to identify research studies published between 2011–2021 using the following database of PubMed, MEDLINE, CINAHL, PsycINFO, and Scopus. Eligible publications were critically reviewed and scored using standardized critical appraisal instruments from the Joanna Briggs Institute.
Results
Twenty-one studies were analyzed. The main factors affecting newly graduated registered nurses’ intention to leave the nursing profession included demographic factors, supervisor and peer support, challenges in the workplace, cognitive and affective response to work, work environment, gender stereotypes, autonomous motivation, role models, and resilience.
Conclusions
The factors affecting newly graduated registered nurses’ intention to leave the nursing profession are multifaceted and should receive continuous attention from nurse managers. The results provide a baseline of data for nurse administrators to develop intervention strategies to mitigate newly graduated registered nurses’ turnover intention.