bluuebunny/crossref_metadata_2025 huggingface dataset:
Zagrożenia hybrydowe bezpieczeństwa informacyjnego państwa
Authors:   Uniwersytet Przyrodniczo-Humanistyczny w Siedlcach, Wyrębek Henryk
Published: May 2023

The annexation of Crimea and the beginnings of Russian aggression in the Donbass area have sparked widespread use in journalistic discourse and scholarly considerations of the concept of hybrid threats. With threats such as spreading false information and manipulating it in a way that undermines the public's trust in government and spreading information that compromises politicians. By attempting to undermine the social contract that binds the state and its constituents, a hybrid actor seeks to undermine trust between state institutions and citizens. As a result, the state loses its legitimacy - which is largely a function of public trust - and thus loses its ability to act as Thomas Hobbes argued in his 1651 work Leviathan. Consequently, a group of hybrid threats pertaining to information activities destroys both the ideological foundations and the state's ability to function smoothly. The article attempts to analyze and assess the essence of hybrid threats that have a major impact on the reduction of the state's information security.
Blogi – elektroniczne pamiętniki – nowoczesną formą utrwalania obrazu ży- cia codziennego polskich emigrantów
Authors:   Uniwersytet Kazimierza Wielkiego w Bydgoszczy, Bierzyńska-Sudoł Magdalena
Published: May 2023

The article describes the genesis of electronic diaries - blogs that have become a modern and popular form of recording the image of everyday life of Polish immigrants. The main scientific purpose of the article was to show emigration blogs as a specific form of personal documents, which, apart from the information function, are a tool for expressing oneself, creating one's own image, and communicating with other emigrants. The research attention was also focused on the structure of blogs, their divisions and classifications, characteristic features, determined mainly by the substantive contents spread throughout the web. The presented examples confirm that blogs, as personal notes, are a very important element of everyday life of emigration diarists, and a wide range of readers. They also fulfill integrating and therapeutic functions and play an important role in maintaining national identity. With the development of technology, they changed their current form, and became mostly video blogs, but they did not lose their original diary face.
„Praga uważa się za „naj...” – konkurencyjność regionów w Republice Cze- skiej w kontekście pragocentryzmu
Authors:   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Bronisz Urszula , Kuć-Czajkowska Katarzyna ,   Uniwersytet Marii Curie-Skłodowskiej w Lublinie
Published: May 2023

The aim of the article was to compare NUTS3 level regions in the Czech Republic in terms of their competitiveness understood as an outcome of the four following dimensions: economic, social, innovative and environmental. The study of competitiveness was intended to verify the thesis of the legitimacy of concentrating development policy (especially in terms of spending EU funds) in the capital city of Prague as the region with the highest potential, providing the greatest guarantees of their effective use. In the article, using the Hellwig method (i.e. relative distances from the benchmark), an empirical analysis of regional competitiveness was carried out. The occurring developmental asymmetry was confirmed by empirical data. Prague is the leader outclassing the other regions in economic, social and innovative dimensions. In a country with significant developmental disparities, disadvantaged units are unable to compete and thus become underdeveloped regions. Praguecentrism therefore causes the increase in development divergence in the Czech Republic. This phenomenon will grow, regardless of the regional development policy.
Polityka etniczna państwa polskiego po 2011 roku w opiniach Komitetu Do- radczego i Komitetu Ekspertów Rady Europy
Authors:   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Browarek Tomasz
Published: May 2023

This article aims to present and analyse the assessment of the ethnic policy of the Polish state made on the basis of the Fourth Opinion on Poland of the Advisory Committee of the Council of Europe on the Framework Convention for the Protection of National Minorities and on the basis of the Third Report of the Committee of Experts on the European Charter for Regional or Minority Languages. The main thesis of the work is the statement that although the ethnic policy of the Polish state has not changed in the analyzed period, some actions of the Polish authorities testify to their certain unfavorability towards the extension of the rights of national minorities, and even in some cases the desire to reduce these rights. The article uses a number of research methods. The most important of them are institutional and legal analysis, factorial method and comparative method.
Odpowiedź Polski i Litwy na kryzys migracyjny przy granicy z Białorusią – próba porównania
Authors:   Uniwersytet Rzeszowski, Ciechanowska Justyna , Szwed Katarzyna ,   Uniwersytet Rzeszowski
Published: May 2023

The aim of this publication is to illustrate the responses of Lithuania and Poland to the migration crisis at the Belarusian border, which began in mid-2021. Both countries are members of the European Union and the Schengen Area. In a situation of threat to internal security, they prioritised securing their national borders, which are also the eastern flank of the European Union, over the protection of human rights or humanitarian issues. The publication shows similarities and differences in the reaction to the Belarus regime's actions on the part of the Polish and Lithuanian authorities. Particular attention was paid to the analysis of the rationale for introducing the state of emergency and the admissibility of limiting human rights and freedoms.
Amendment to the act on civilian victims of war and the legal situation of children of war rape in Bosnia and Herzegovina
Authors:   Uniwersytet Rzeszowski, Czeszejko-Sochacka Katarzyna
Published: May 2023

War rape is a phenomenon that occurs in almost every armed conflict. The circle of victims includes not only the persons directly affected by this crime, but also their next of kin. Unwanted pregnancies as a result of wartime rape result in children who, from the moment they are born, are treated as inferior persons. Apart from marginal cases, the internal laws of individual states do not grant them any protection or compensation. For some time now, however, a change in this direction has been evident on the international stage. Bosnia and Herzegovina is the first European country which has responded to these calls and has taken steps to change the status of children from war rape.
Stare medium w nowej szacie. Prasa w komunikacji lokalnej
Authors:   Uniwersytet Jana Kochanowskiego w Kielcach, Kępa-Mętrak Jolanta
Published: May 2023

Media communication at all levels is influenced by both socio-political, economic and technological factors. Local press is subject to them in the same way as other media, but due to their specificity (incl. being limited to small target group and at the same time more direct impact on recipients), it often must deal with additional factors that determine its existence. By analyzing selected examples of local publishing houses (case studies), and data from Polish Reading Research and organizations associating local publishers (desk research), the author tries to identify the most important changes taking place in media communication at the local level. Research confirms that the changes mainly affect channels of media communication. Printed press attracts less and less attention of recipients. Its past functions are taken over by the Internet. Until recently, the Internet was an addition to the traditional methods of communication on the local media market. Now it takes the audience from the press, radio and television and forces local broadcasters to look for a place for themselves in it.
System ochrony Polski przed bronią masowego rażenia
Authors:   Uniwersytet Rzeszowski, Koziełło Tomasz
Published: May 2023

The article characterises the system of protection of the population, animals, natural environment and infrastructure located in the territory of the Republic of Poland against weapons of mass destruction (WMD), which include nuclear, radiological, biological and chemical weapons. The text is divided into seven parts, which discuss the types of WMD, the WMD protection system as a whole and its five components. Each section outlines the organisational and legal structure of this system and subsystems, and the tasks assigned to each of the bodies that comprise them.
EFFECT OF PLASMA-CHEMICALLY ACTIVATED AQUEOUS SOLUTIONS ON THE PROCESS OF DISINFECTION OF FOOD PRODUCTION EQUIPMENT
Authors: Pivovarov О. , Kovaliova О. , Koshulko V.
Published: May 2023

Abstract. In food production, it is essential to implement preventive measures aimed at improving the quality of products, namely decontaminating them of microorganisms causing food poisoning. Effective sanitisation of food production equipment allows preventing products’ contamination by pathogenic microflora and by microorganisms that lead to spoilage of food. The paper presents a study of the effect of plasma-chemically activated aqueous solutions on the process of disinfection of food production equipment. Activated aqueous solutions have been characterised, and it has been shown how they affect pathogenic microflora present on the surfaces of equipment involved in meat production and processing. Analysis of microbiological indicators (QMAFAnМand coliform bacteria) has shown that the number of pathogenic bacteria decreased by half on all surfaces of the processing room even at the peroxide concentration 100 mg/l, while at the concentration 500 mg/l, we observed complete destruction of pathogenic microflora both in the poultry slaughter room and in the diseased animal slaughterhouse. The disinfecting properties of plasma-chemically activated aqueous solutions in the process of production of chicken mincehave been analysed. After the surfaces of the cutters were treated with the activated aqueous solutions having the peroxide concentration 500 mg/l, the equipment was found to be completely sterile: no microflora was detected in the wipe samples, and this dynamics was observed for 7 days. The use of the disinfectant proposed stops the development of any microflora on the surface of technological equipment. The level of microbiological contamination of the finished meat product (chicken mince) after treating the equipment with plasma-chemically activated solutions has been studied, their peroxide concentrations being 100 to 700 mg/l. No pathogenic microflora (in particular, nocoliform bacteria and mould) was detected in the finished meat products obtained after the equipment was treated with the disinfectant solution at a concentration higher than 500 mg/l. Plasma-chemically activated aqueous solutions with the concentration of peroxides 500 mg/l are considered optimal for disinfection of the technological surfaces and equipment of meat processing enterprises, since they ensure complete removal of pathogenic microflora and allow obtaining a product free from pathogens.
THE AMINO ACID COMPOSITION OF MEAT PRODUCTS TREATED WITH PREPARATIONS OF MICROBIAL ORIGIN
Authors: Danylenko S. , Naumenko O. , Ryzhkova T. , Fediaiev V. , Verbytskyi S. , Korol Ts.
Published: May 2023

Fermentation in the technology of dry-cured meat products helps to create products with high sensory characteristics and an extended shelf life. The purpose of this work was to study how bacterial and enzyme preparations affected the accumulation of free amino acids in dry-cured meat products.
The work considers how the preparation Iprovit-Lakmik based on the cultures L. plantarum, L. rhamnosus, L. casei, and Micrococcus varians acts on the accumulation of free amino acids during the ripening of dry-cured sausages, and how the bacterial preparation Iprovit-MKS based on the cultures Lactoba plantarum, L. rhamnosus, and Staphylococcus simulans and the enzyme preparation Protolad acts on proteolysis during the ripening of dry-cured whole-muscle products from pork and beef. Fermentation was carried out in a climatic chamber at a temperature required by the technological process of accelerated ripening of fermented sausages, using bacterial and enzyme preparations. The starter culture Iprovit-Lakmik was added in the amount 0.05% to the volume of the sausage mince prepared in accordance with the formulation of the dry-cured sausage Zhytomyrska. The preparations Protolad and Iprovit-MKS were added at the stage of injecting the balyk (cured fillet) Darnitsky. Samples with no preparations added were the controls. The amino acid composition of proteins was determined by ion-exchange chromatography on an automatic amino acid analyser Biotronik LC2000. The total content of free cyclic amino acids was determined by the Hull method, and that of acyclic amino acids by the Gomez method, using colourimetry.
It has been found that after fermentation, each product had its own characteristics of the qualitative and quantitative accumulation of free amino acids. Adding the preparation Iprovit-Lakmik to raw meat allowed directed biochemical transformations with the formation of a significant amount of free amino acids, which exceeded the control by 115.86 mg/100 g of dry matter. The enzyme preparation Protolad has a positive effect on the chemical and physicochemical characteristics of salted products from pork and beef. It has been proved that its use activates the breakdown of muscle tissue proteins and increases the pool of free amino acids. In the test samples from pork and beef, the content of free amino acids increased, respectively, by 1.7 times and 3.4 times, and that of non-essential amino acids by 1.4 times and 1.3 times respectively, compared with the control. In the samples with the bacterial preparation Iprovit-MKS, the total amount of amino acids increased significantly: by 32% for beef balyk and by 20% for pork balyk.
Diversity of hypertension in obesity
Authors: Chumakova G. A. , Kuznetsova T. Yu. , Druzhilov M. A.
Published: May 2023

Induced hypertension (HTN) is one of the HTN types, the pathogenetic mecha­nisms of which are well studied: its main cause lies in the dysfunction of visceral adipose tissue, which leads to renin-angiotensin-aldosterone system activation, imbalance of the sympathetic and parasympathetic systems, renal involvement, and then to vascular endothelium dysfunction and, in fact, to an increase in blood pressure and HTN consolidation. However, within this HTN form, some mechanisms can be distinguished that, in obesity, play a special role. This review describes such additional mechanisms as chronic inflammation, excessive salt intake, dys­biosis, environmental factors. Understanding these HTN features in obesity has es­sential for achieving target blood pressure levels. In addition, the review pays special attention to such HTN forms in obesity as masked and nocturnal, the timely diagnosis of which is extremely important for the timely initiation of therapy and improving the prognosis.
Innovative lipid-lowering therapy: experience of inclisiran use in the Republic of Belarus
Authors: Medvedeva E. A. , Grigorenko E. A. , Mitkovskaya N. P.
Published: May 2023

The article reflects modern aspects of lipid-lowering therapy, based on the as­sessment of cardiovascular risk, and the possibilities of triple therapy, including statins, ezetimibe, and inclisiran.

We present our own data on the use of the drug inclisiran in patients with lipid metabolism disorders in the framework of secondary and primary cardiovascular prevention. Low-density lipoprotein levels at different times after the injection is described. The potential of innovative lipid-lowering therapy in liver transplant recipients in the long-term postoperative period are discussed.

The addition of inclisiran to statin and ezetimibe therapy is safe and leads to a decrease in low-density lipoprotein levels by more than 50% of baseline values in the general population.
Identification of sex characteristics of obesity and hypertension in the adult population of the Vladimir region
Authors: Mamedov M. N. , Sushkova L. T. , Isakov R. V. , Kutsenko V. A. , Drapkina O. M.
Published: May 2023

Aim. To identify sex characteristics of the prevalence of obesity and hypertension (HTN) in the adult population of the Vladimir region.

Material and methods. The study included 1350 people, men and women aged 30-69 years from 5 cities of the Vladimir region (Vladimir, Kovrov, Murom, Yuriev-Polsky and Vyazniki). The response rate was at least 80%. In total, 1174 people completed the study, including 424 men (36,1%) and 750 women (63,9%). The survey was conducted according to a standard questionnaire, including socio-demographic parameters and behavioral risk factors. In all patients, anthropometric parameters, blood pressure, heart rate and resting electrocardiography were assessed.

Results. The average body mass index among women was significantly highercompared to men (29,9±6,2 kg/m2 vs 28,3±4,7 kg/m2, p<0,001), while waist circumference among men exceeded similar parameters among women (95,5±11,7 cm vs 91,9±15,3 cm, p<0,001). Sex differences in anthropometric indicators have a number of features in different cities. Every third man is obese, while among women this figure was significantly higher (33,7% vs 42,1%, p<0,001). Every second man and 2/3 of women had abdominal obesity (53,1% and 71,6%, p<0,001). The prevalence of HTN among men and women was comparable (41,5% and 39,9%, respectively). Electrocardiographic signs of left ventricular (LV) hypertrophy are detected in every third respondent, while its prevalence between men and women did not differ statistically (30,5% and 35,5%, respectively).

Conclusion. In the surveyed population of men and women of the Vladimir region, the prevalence of obesity and HTN were comparable. The prevalence of obesity and abdominal obesity has sex differences due to the greater severity among women. Hypertension is also highly likely to be associated with LV hypertrophy. Obviously, in order to correct obesity and HTN, lifestyle changes at the population level must be combined with the use of antihypertensive therapy to achieve target blood pressure levels and regress LV hypertrophy.
CSRP2 transcript levels after consolidation therapy increase prognostic prediction ability in B-cell acute lymphoblastic leukaemia
Authors: Cao Lei-Ming , Zhou Ya-Lan , Gale Robert Peter , Qin Ya-Zhen , Wu Li-Xin , Zhao Ming-Yue , Zhao Xiao-Su , Chen Yu-Hong , Wang Yu , Jiang Hao , Jiang Qian , Chang Ying-Jun , Liu Yan-Rong , Xu Lan-Ping , Zhang Xiao-Hui , Huang Xiao-Jun , Ruan Guo-Rui
Published: May 2023

Quantification of measurable residual disease (MRD) correlates with the risk of leukaemia recurrence in adults with B-cell acute lymphoblastic leukaemia (ALL). However, it remains unknown whether collecting data on cysteine and glycine-rich protein 2 (CSRP2) transcript levels, after completing the second course of consolidation, improves prognosis prediction accuracy. A total of 204 subjects with B-cell ALL were tested for CSPR2 transcripts after completing the second course of consolidation using quantitative real-time polymerase chain reaction (qRT-PCR) and divided into high (N = 32) and low (N = 172) CSRP2 expression cohorts. In multivariable analyses, subjects with high expression of CSRP2 had a higher 5-year cumulative incidence of relapse (CIR) (Hazard Ratio [HR] = 2. 57 [1.38, 4.76]; P = 0.003), lower 5-year relapse-free survival (RFS) (HR = 3.22 [1.75, 5.93]; P < 0.001) and overall survival (OS) (HR = 4.59 [2.64, 7.99]; P < 0.001) in the whole cohort, as well as in the multiparametric flow cytometry (MPFC) measurable residual disease (MRD)- negative cohort (for CIR, HR = 2.70 [1.19, 6.12]; for RFS, HR = 4.37 [1.94, 9.85]; for OS, HR = 4.90 [2.43, 9.90];  P < 0.05). Prognostic analysis showed that allogeneic hematopoietic stem cell transplantation (allo-HSCT) could significantly improve the prognosis of patients with high CSRP2 transcript levels (allo-HSCT vs chemotherapy: 5-year CIR, 52% vs 91%; RFS, 41% vs 9%; OS, 38% vs 20%; P < 0.05). Our data indicates that incorporating data from CSPR2 transcript levels to the MRD-testing at the end of the second course of consolidation therapy enhances prognosis prediction accuracy in adults with B-cell ALL.
Time-frequency Representation -enhanced Transfer Learning for Tool Condition Monitoring during milling of Inconel 718
Authors: Zhou Yuqing , Sun Wei , Ye Canyang , Peng Bihui , Fang Xu , Lin Canyu , Wang Gonghai , Kumar Anil , Sun Weifang
Published: May 2023

Accurate tool condition monitoring (TCM) is important for the development and upgrading of the manufacturing industry. Recently, machine-learning (ML) models have been widely used in the field of TCM with many favorable results. Nevertheless, in the actual industrial scenario, only a few samples are available for model training due to the cost of experiments, which significantly affects the performance of ML models. A time-series dimension expansion and transfer learning (TL) method is developed to boost the performance of TCM for small samples. First, a time-frequency Markov transition field (TFMTF) is proposed to encode the cutting force signal in the cutting process to two-dimensional images. Then, a modified TL network is established to learn and classify tool conditions under small samples. The performance of the proposed TFMTF-TL method is demonstrated by the benchmark PHM 2010 TCM dataset. The results show the proposed method effectively obtains superior classification accuracies for small samples and outperforms other four benchmark methods.
A mechanism reliability analysis method considering environmental influence and failure modes’ correlation: a case study of rifle automaton
Authors: Fang Yi-chuan , Wang Yong-juan , Sha Jin-long , Gu Tong-guang , Zhang He
Published: May 2023

In order to overcome the challenge of quantifying the influence of environmental conditions and the coexistence of multiple failure modes involved in mechanism reliability modelling under different environments. In this paper, we propose a method for the analysis of mechanism reliability that takes into account the influence of environmental factors and failure modes’ correlation, quantifies the influence of environmental factors as the random distribution and degradation path of parameters, and derives the Copula description of failure mode correlation from the historical data of environmental experiments. On the basis of the discrete mechanism dynamics model, the output parameters of the characteristic points are calculated, and the failure rate of each failure mode is calculated based on the failure criterion and the performance margin theory. Additionally, the dynamic change pattern of the mechanism reliability is compared with the Kaplan-Meier estimation of the corresponding environmental test history data to assess the validity of the calculation results. The reliability modelling problem of a motion mechanism of an automatic rifle automaton in a high and low temperature environment is applied to the method, and the reliability calculation results are close to those of Kaplan-Meier estimation of the test history data, and all are within the upper and lower bounds given by the reliability boundary theory, demonstrating the method's validity.
Molecular genetics features of anaplastic thyroid carcinoma
Authors: Musonova Anastasia K. , Nazarov Vladimir D. , Sidorenko Daria V. , Musaelyan Aram A. , Alekseeva Ekaterina A. , Kuzovenkova Daria A. , Kozorezova Evgeniya S. , Vorobev Sergey L. , Orlov Sergey V. , Mazing Aleksandrа V. , Lapin Sergey V. , Emanuel Vladimir L.
Published: May 2023

INTRODUCTION: Anaplastic thyroid carcinoma (ATC) is the most aggressive type of thyroid cancer accounting for 12% of all malignancies. Systemic therapy remains the main treatment strategy. Targeted therapy and immunotherapy are prescribed when certain molecular genetic aberrations are detected.
THE AIM: To investigate the molecular genetic profile of samples of anaplastic thyroid carcinoma.
MATERIALS AND METHODS: The study included 37 patients with ATC. Mutation V600E BRAF, mutations in the gene NRAS and KRAS were detected by allele-specific polymerase chain reaction (AS-PCR). Microsatellite instability (MSI) was determined by fragment analysis in according to ESMO recommendations. Mutations in the promoter region of the TERT gene were used by Sanger sequencing. NTRK1, EML4-ALK, PAX8/PPARy и RET/PTC translocations were determined in all patients with ATC by real-time polymerase chain reaction (PCR).
RESULTS: According to the results of the study, the frequency of the V600E mutation in the BRAF gene was 32.4% (12/37). The frequency of aberrations in the NRAS, KRAS genes in anaplastic thyroid carcinoma was 13.5% (n=5). The prevalence of point mutations in the promoter gene TERT in food samples of ATC was 24.3% (n=9). MSI was found in 2.7% (1/37) of cases of anapalastic thyroid carcinoma. NTRK1, EML4-ALK, PAX8/PPARy and RET/PTC translocations were not detected in cases with anaplastic thyroid carcinoma.
CONCLUSION: The further study of the main specific molecular targets in cancer cells will allow to personalize the tactics of patients with anaplastic thyroid carcinoma.
Features of the endothelial status in patients with gastric cancer and its impact on surgical treatment outcomes
Authors: Olzhaev Sayakhat T. , Shoykhet Yakov N. , Lazarev Alexander  F. , Adjibayev Baurzhan J.
Published: May 2023

BACKGROUND: The incidence of gastric cancer is still high and holds the leading place in the structure of oncological pathology in the world. Prognostic aspects in the treatment of generalized forms of gastric cancer are currently under revision.
AIM: To study functional status of vascular endothelium in patients with gastric cancer in perioperative period and evaluate its influence on the outcomes of surgical treatment.
MATERIALS AND METHODS: A prospective, randomized study was conducted from 2009 to 2019. Two populations were studied: healthy individuals (control group, n=40); patients diagnosed with gastric cancer (general group, n=122). Patients with gastric cancer underwent gastrectomy with lymphodissection.
The functional state of the vascular endothelium was studied: the volume of circulating endotheliocytes (CCE); the level of von Willebrand factor (VF) and the degree of endothelium-dependent vasodilation (EDV). To study their prognostic significance we calculated a conventional cut-off point.
RESULTS: The general group patients were divided into 2 subgroups: the main group the laparoscopic access (n=54) and the comparison group the laparotomy access (n=68).
Endothelial dysfunction (EDF) correction with Glutargin 1.0 g per day in combination with Enalapril 2.5 mg per day was additionally used in the main subgroup.
In the main group, the values of CCE and VF were lower (8.33.0 and 84.621.3, respectively) and the values of EDV were higher (13.73.9) in contrast to the comparison group (p 0.0001).
Use of the EDF correction method in the main group resulted in a 4.4-fold and 5.1-fold decrease in CCE and VF concentrations, respectively, and a 4.3-fold normalization of EDV (p 0.0001). Increase of CCE concentration more than 7.0 per 103 platelets; PV more than 120 g/ml, as well as decrease of EDV below 14% in the study stages increased the risk of postoperative complications by 2.9; 1.7 and 1.8 times, respectively (p 0.0001).
The incidence of surgical complications was 19.7% and non-surgical complications 31.1%. Hospital mortality was 3.3% and out-of-hospital mortality with up to three years follow-up was 13.1%.
The number of purulent-septic complications in the main group was 2.9 times lower, and the rate of thrombotic complications was 4 times lower than in the comparison group (p 0.05).
CONCLUSION: Combined use of laparoscopic technique by EDF medication correction reduces manifestations of stress reaction and decreases the potential risk of complications development in the postoperative period. Elevation of CCE, as well as EDV decrease beyond the relevant excision points in patients with gastric cancer in the perioperative period are prognostic predictors of the risk of purulent-septic and thrombotic complications development.
Difficulties and possibilities of cytodiagnosis of origin of adenocarcinoma in cervical smears
Authors: Grigoruk Ol’ga G. , Moskvina Москвина  A. , Bazulina Larisa M. , Bakharev Sergej Ju. , Pupkova Elena Je. , Elchaninova Svetlana A.
Published: May 2023

BACKGROUND: The duration and accuracy of verification of origin and morphological variant of adenocarcinoma in the cervical smear affect the effectiveness of the treatment of patients. Currently, few publications on the possibility of clarifying the origin of adenocarcinoma in a cervical smear using the traditional cytological method are not sufficient for evidence-based conclusions.
AIMS: To identify patterns of cytological indicators of origin of adenocarcinoma in the biomaterial from the cervix.
MATERIALS AND METHODS: In an observational one-stage retrospective study, a comparative analysis of cytological tests of cervical smears with the conclusion adenocarcinoma was carried out with clinical and anamnestic information and the results of histological, immunohistochemical, molecular and genetic examinations. Information about 143 patients in the cancer registry of the Altai Regional Oncological Dispensary (Barnaul) for 2021 was used for analysis. Cytology preparations were prepared by the traditional method, as well as by the method of liquid cytology, staining was carried out by the Papanicolaou (Pap Test) and Pappenheim methods. Testing for human papillomavirus (HPV) was carried out by immunohistochemical method and polymerase chain reaction. PIK3CA and KRAS mutations were detected by polymerase chain reaction.
RESULTS: The cytological conclusion adenocarcinoma was confirmed by histology for all 143 women. There were cytology features of the morphological variant of AC, as well as to suggest the primary organ of adenocarcinoma, subsequently verified by visualization methods, histological, immunohistological examinations of biopsy and/or surgical material. The adenocarcinoma elements in the cervical smear was accompanied by adenocarcinoma in the endometrium, cervix, ovary/fallopian tube, colon (68.5, 17.6, 9.8 and 2.8% of cases, respectively; p 0.001). Differentiation of endometrial adenocarcinoma varied. Clear cell adenocarcinoma had specific cellular features. Cellular characteristics of HPV-associated and HPV-unassociated endocervical carcinomas differed from each other. Invasion of intestinal adenocarcinoma into the uterus and cervix was characterized by complexes with a palisade arrangement of cells in cervical smears.
CONCLUSION: Cytolodiagnostics of adenocarcinoma in smear from the cervix has prospects for further improvement in the verification of the organ origin of carcinoma. It is assumed that it is rational to assess associations of cytology with histo-, cytochemical, molecular and genetic characteristics of adenocarcinoma.
Lobular carcinomas of the breast: cytological diagnostics
Authors: Grigoruk Ol’ga  G. , Moskvina Tat’jana A. , Михайловна Larisa  M. , Sinkina Tat’jana V. , Vihljanov Igor’ V.
Published: May 2023

AIMS: To estimate potentialities of cytological diagnostics of different types of lobular carcinomas of the breast while outpatient examination.
MATERIALS AND METHODS: The data of cytological investigations of 444 patients with carcinoma, which were detected by fine-needle aspiration biopsy, were studied. Traditional cytological diagnostics, as well as the liquid-based technique of preparation of patterns were used, staining of patterns according to the Pappenheim and Papanicolaou methods. A standard protocol for immunocytochemical reactions was used.
RESULTS: Lobular carcinoma was detected in 15 patients. Types of lobular carcinomas were verified by cytological method were retrospectively identified.
Classical, solid and tubular types of lobular carcinoma (n=7,46.7%; n=5,33.3%; n=1,6.7%) differed from unspecified breast carcinomas. In the classical type, vacuoles with a target-like inclusion (probably a drop of mucin) were a significant feature. In the solid type, the absence of complexes with a large number of separately located similar tumor cells was noticed. The tubular type was distinguished by the presence of tubular structures. The liquid-based technique helps to differentiate lobular and unspecified carcinoma using an immunocytochemical reaction with E-cadherin.
CONCLUSION: The results of the study indicate that lobular carcinomas of the breast are 3.4% of all breast carcinomas. Taking into consideration the differences in prognosis, it is important to differentiate between lobular and unspecified ductal carcinoma at the outpatient level of diagnostics, as this is deciding for treatment strategy choice.
SOSYAL HİZMETTE QUEER BAKIŞ AÇISI: TOPLUMSAL CİNSİYET ROLLERİNDEN BAĞIMSIZ BİR YAKLAŞIMA DOĞRU
Authors: Kara Yunus , Serpen Ayşe
Published: May 2023

Bu çalışmada, Türkiye’deki sosyal hizmet alanı ve queer teorinin ilişkilendirilmesi ve mesleki uygulamalara yansıtılması konusundaki eksikliğin ortaya konması amaçlanmaktadır. Bu çerçevede, öncelikle tarihsel olarak, sosyal hizmet disiplininin queer teoriyi nasıl ele aldığını ve bu ele alışın nasıl değişip dönüştüğünü (veya dönüşmediğini) ve bunun karşısında eleştirel sosyal hizmet, radikal sosyal hizmet ve baskı karşıtı sosyal hizmet yaklaşımlarının konuya nasıl baktığının anlaşılması, ardından queer teorinin sosyal hizmet müdahale süreçlerinde nasıl uygulanabileceğine dair toplumsal cinsiyet rollerinden bağımsız bir yaklaşımın sunulması öngörülmektedir. Toplumsal cinsiyet rollerinden bağımsız bir yaklaşım, ikili cinsiyet sistemi üzerinden kadınlara ve erkeklere atanan rollerin, olguların ve durumların, biyolojik olarak belirlenmelerinden ziyade toplumsal olarak inşa edildiğini, değişebildiğini ve toplumdan topluma, kültürden kültüre farklılaştığı fikrini bünyesinde barındırmaktadır. Tüm bu tartışmalarla birlikte sosyal hizmetin queer teori bağlamında geçirdiği dönüşümlerin eleştirel bir analizinin yapılması ve buradan hareketle queer teorinin bakış açısının ortaya konulması sağlanarak, sosyal hizmetin queer perspektifle ilişkilenme biçiminin, sosyal hizmete sağlayabileceği imkânların ortaya konulması amaçlanmaktadır.
Between leading and lagging
Authors: González-Leonardo Miguel
Published: May 2023

In this paper, we analyse the interregional migration of Spanish-born young adults by educational attainment and explore unemployment and over-education in the labour market among internal migrants and sedentary individuals with a university degree. We used register data of population movements from 2000 to 2018 to analyse internal migration patterns and the Labour Force Survey to study the educational attainment of migrants, as well as unemployment rates and over-education among college graduates. Our results indicate a regional polarisation after the economic crisis. Peripheral regions in the interior of Spain have been affected by an increasing exodus of university graduates, in addition to high levels of unemployment and over-education among individuals with a university degree who remain at origin. However, peripheral regions in the north-west and south of Spain have been less affected by out-migration, even though the south has shown higher levels of unemployment for college graduates. The central region of Madrid has emerged as the main destination for university graduates, with a large capacity to employ populations with university education from other regions. Semi-central regions of the Mediterranean and north-east of Spain retain local college graduates and exhibit good labour market conditions among residents with a university degree, but they are not destinations of individuals with university education from other regions.
Информационные технологии в условиях пандемии COVID-19
Authors: Дворянкин О.А. , Сермягин К.А.
Published: May 2023

В настоящей статье проводится исследование информационных технологий Интернета в новых условиях - в период пандемии (COVID-19). Изучены причины, с помочью которых короновирус повлиял на IT-инфраструктуру, а также рассмотрен положительный опыт применения информационных технологий в борьбе с пандемией. Представлен прогноз по развитию мировые тренды в ИТ-сфере после пандемии.
Безопасность в интернете
Authors: Просянникова Д.А. , Федорова А.Е. , Ермолаева В.В.
Published: May 2023

В статье поднимается тема безопасного использования гаджетов. В современном мире мы часто пользуемся компьютерами, телефонами и другими различными гаджетами. С их помощью мы посещаем различные социальные сети, сайты на которых просматриваем различный контент. К сожалению, на просторах интернета мы сталкиваемся с такими проблемами как: вирусы, мошенничество, неприличный и опасный контент и т.д. Именно эти проблемы мы и разберём в данной статье.
Корреляция грамматических временных параметров в английском и русском языках
Authors: Гончарова А.В. , Калашникова О.К.
Published: May 2023

Данная статья анализирует проблемы взаимоотношения языковых форм с понятием смысла высказывания. Для анализа были выбраны базовые видовременные категории в английском и русском языках. Проанализированы основные временные лакуны и сделаны выводы о сложных типах взаимодействия языковых явлений на фоне возрастающей модификации семантических связей между языковыми формами и смыслом в зависимости от контекста высказывания.
Биоэтическая культура как квинтэссенция подготовки современного учителя
Authors: Харченко Л.Н. , Магомедова А.Н.
Published: May 2023

Анализ теории и практики исследуемой проблемы, показал, что постоянно происходящие в обществе и науке перемены вызывают отклик и перемены в сфере образования. Поэтому ученые и учителя – практики ищут формы, средства, методики и технологии образования, в которых был бы заложен воспитательный потенциал, повышающий эффективность подготовки обучающихся к жизни и деятельности.
Specificities of burials of founder women in the Low-Vychegda Chezhtyyag burial ground
Authors: Savel'eva E.
Published: May 2023

The materials of excavations of a separate group of burials of founder women in the Low-Vychegda Chezhtyyag burial ground dating back to the XIII century are introduced into scientific discourse. Based on the typological and chemical analysis of grave goods, the author identified the characteristic features of the burials. Grave goods include items of bronze foundry production, metal ingots and a scrap for making adornments, casting tools, many women’s adornments, numerous findings in the inter-grave space and a great number of artefacts that have been fired. There are no items related to the sphere of men’s production activities or weapons items. Next to the burials of women-foundry workers, there are small burials of teenage girls, apprentices of adult women. The rich implements of burials, many beads, a tamga trace on one of the vessels indicate a high social status of the buried founder women, endowing them with magical properties.
The Effects of Fermentation Extent and Acid Concentration on Bioethanol from HVS Paper Waste
Authors: Mulyawan Rizka , Nurlaila Rizka , Ahmadi Tsa Tsa Anindya Rakhim , Muhammad Muhammad , Sylvia Novi , Muarif Agam
Published: May 2023

ABSTRACT. Bioethanol is an alternative energy sourced from environmentally friendly raw materials from wastes that contain a lot of lignocellulosic such as HVS paper. Paper contains about 85% cellulose, 8% hemicellulose, 5% lignin and the rest is in the form of ash compounds. Bioethanol is ethanol produced from the fermentation of glucose (sugar) followed by a distillation process. This study aims to analyze the effect of a combination of fermentation time and concentration of sulfuric acid on bioethanol. The highest yield of beathanol was obtained at a hydrolysis concentration of 6.5% with a 7-day fermentation time of 3.45%. Bioethanol density that was close to standard was 3.5% acid concentration with 3 and 5 days fermentation. Moreover, at 3.5% acid concentration showed the closest bioethanol viscosity to the standard value with all conditions synthesized acidic bioethanol with pH ranged from 6 to 6.5
Statins and highly sensitive cardiac troponins: cardiotoxicity or cross-reactivity?
Authors: Chaulin A. M. , Duplyakov D. V.
Published: May 2023

To date, hypolipidemic drugs of the statin group are among the most popular therapeutic agents used for the prevention and treatment of the most common worldwide atherosclerotic cardiovascular diseases (CVD). Therefore, considerable attention of researchers is focused on statins to study the additional effects of these drugs, which is accompanied by the discovery of new mechanisms of action and properties that should be taken into account to optimize the tactics of managing patients with CVD. In addition to the key lipid-lowering effect of statins associated with the inhibition of the ratelimiting enzyme (3-hydroxy-3-methylglutaryl-coenzyme A reductase), researchers report a variety of other properties of these drugs. Important circumstances contributing to the disclosure of new effects of statins are: improvement of research methods, and first of all, their sensitivity and specificity; the discovery of new molecules and molecular pathways that may be affected by statins. In general, the currently established numerous non-lipid effects of statin drugs can be divided into two groups: favorable and side effects, which must be taken into account when managing patients with CVD and comorbid diseases. Thanks to recent studies using modern clinical diagnostic cardiomarkers (highly sensitive cardiac troponins (CT)), molecular genetic and morphological methods, potential cardiotoxic properties of statin group drugs have been identified. Of particular concern are the data on a statininduced increase in the concentration of highly sensitive CT, which are a key and generally recognized criterion for myocardial damage. In this article we discuss possible mechanisms of increasing the concentration of CT and cardiotoxic effects when using statins.
Pengaruh Green marketing, Environmental concern, dan Attitude toward behavior terhadap Purchase intention: Studi Pada Laki-kaki Pengguna Skincare Lokal di DKI Jakarta
Authors: Vannia Dhea , Muhammad Sadat Andi , Pratama Sari Dewi Agustin
Published: May 2023

Saat ini skincare juga digunakan oleh pria, tidak hanya wanita. Mereka sadar bahwa menjaga dan merawat kulit merupakan kebutuhan setiap individu. Bersamaan dengan itu, dalam beberapa dekade terakhir, isu lingkungan mendapat perhatian publik dan kepedulian masyarakat terhadap lingkungan semakin meningkat. Mereka mulai menyadari bahwa aktivitas sekecil apapun yang dilakukan oleh manusia akan berdampak pada lingkungan, dan salah satu bentuk kepedulian mereka terhadap lingkungan adalah dengan menggunakan produk yang lebih ramah lingkungan. Penelitian ini bertujuan untuk menganalisis dan mengetahui pengaruh green marketing, environmental concern, dan attitude toward behavior terhadap purchase intention pada pria pengguna skincare di DKI Jakarta. Penelitian ini menggunakan pendekatan kuantitatif dengan software AMOS 21. Sampel yang digunakan sebanyak 243 partisipan, dengan teknik pengambilan sampel menggunakan purposive sampling. Hasil penelitian menunjukan bahwa green marketing secara signifikan tidak berpengaruh terhadap purchase intention. Environmental concern berpengaruh positif dan signifikan terhadap purchase intention. Attitude toward behavior berpengaruh positif dan signifikan terhadap purchase intention.
Memprediksi Repurchase Intention pada Aplikasi Bimbingan Belajar Online
Authors: Maharani Putri  , Suhud Usep , Dewi Agustin Pratama Sari
Published: May 2023

Penelitian ini bertujuan untuk mengetahui pengaruh secara langsung brand ambassador, service quality, dan brand image terhadap repurchase intention. Metode yang digunakan pada penelitian ini menggunakan metode kuantitatif. Metode pengumpulan data pada penelitian ini menggunakan metode survey dengan menyebarkan kuesioner. Objek pada penelitian ini adalah responden dengan usia 17-20 tahun dan pernah berlangganan bimbingan belajar secara online melalui aplikasi Ruangguru. Jumlah responden pada penelitian ini sebanyak 243 orang. Teknik analisis data pada penelitian ini menggunakan SEM dengan bantuan aplikasi SPSS Versi 25.0 dan AMOS 25. Hasil pengujian hipotesis menunjukan bahwa semua variabel berpengaruh secara signifikan dan positif terhadap repurchase intention aplikasi bimbingan belajar Ruangguru.

 

This study aims to determine the effect of brand ambassador, service quality, and brand image on repurchase intention. This research uses quantitative methods. The data collection method in this study used a survey method by distributing questionnaire. The object of this research is respondents aged 17-20 years and have subscribed to online tutoring through the Ruangguru application. The number of respondent in this study were 243 people. The data analysis technique in this study analyzed by using SEM assisted by SPSS Version 25 and AMOS applications. The results of hypothesis all variables has significant positive effect on Repurchase Intention.
Pengaruh Beban Kerja, Stres Kerja, dan Work Family Conflict Terhadap Burnout Karyawan
Authors: Lineuwih Intan Inggis , Sariwulan Tuty , Fidhyallah Nadya Fadillah
Published: May 2023

Seiring dengan perubahan dunia kerja yang terdampak dari adanya Covid-19, setiap perusahaan perlu meminimalisir risiko yang dapat muncul dari adanya perubahan tersebut. Hadirnya burnout syndrome dapat menjadi sebuah risiko yang dapat mengancam kualitas hidup perusahaan dan produktivitas karyawan. Tujuan dari penelitian ini yaitu menganalisis burnout pada karyawan yang dipengaruhi oleh beban kerja, stres kerja, dan work family conflict. Penelitian ini tergolong tipe penelitian asosiatif dengan pendekatan penelitian kuantitatif. Metode penelitian yang digunakan ialah metode sensus (sampel jenuh). Jumlah sampel yang digunakan sebanyak 60 responden. Proses pengumpulan data menggunakan kuesioner yang selanjutnya dianalisis melalui teknik analisis regresi linear berganda (multiple linear regression). Berdasarkan perolehan data dapat disimpulkan beban kerja (X1) berpengaruh positif dan tidak signifikan terhadap burnout (Y) pada karyawan. Stres kerja (X2) berpengaruh postitif dan signifikan terhadap burnout (Y) pada karyawan. Work family conflict (X3) berpengaruh positif dan signifikan terhadap burnout (Y) pada karyawan. Secara simultan beban kerja (X1), stres kerja (X2), dan work family conflict (X3) berpengaruh positif dan signifikan terhadap burnout (Y) pada karyawan.
Pengaruh Pengembangan Karir dan Beban Kerja terhadap Kepuasan Kerja Karyawan
Authors: Aisy Rohadatul , Susita Dewi , Handaru Agung Wahyu
Published: May 2023

ABSTRACT

The purpose of this study was to determine the effect of career development and workload on job satisfaction in employees of PT X. This study took a sample of 86 employees of PT X. This study used descriptive analysis and multiple regression analysis. Data analysis techniques use the IBM SPSS Statistical 25 program to process and analyze research data. The results of this study show that career development has a positive and significant effect on job satisfaction, workload has a significant negative influence on job satisfaction, and career development and workload have a significant effect on job satisfaction.

ABSTRAK

Tujuan dalam penelitian ini adalah untuk mengetahui pengaruh pengembangan karir dan beban kerja terhadap kepuasan kerja pada karyawan PT X. Peneliti mengambil sampel sebanyak 86 karyawan PT X. Penelitian ini menggunakan analisis deskriptif dan analisis regresi berganda. Teknik analisis data menggunakan program IBM SPSS Statistik 25 untuk mengolah dan menganalisis data hasil penelitian, Hasil pada penelitian ini menjukkan bahwa pengembangan karir berpengaruh positif dan signifikan terhadap kepuasan kerja, Beban kerja memiliki pengaruh negatif signifikan terhadap kepuasan kerja, dan pengembangan karir dan beban kerja berpengaruh secara signifikan terhadap kepuasan kerja.