bluuebunny/crossref_metadata_2025 huggingface dataset:
A ciência e o cristianismo: Uma análise crítica da aplicação da cosmovisão cristã na ciência através da polêmica entre Teoria da Evolução e o Design Inteligente
Authors: Tourinho Francisco Das Chagas Nascimento Sousa
Published: July 2017

Nesse artigo defenderemos não haver uma guerra real entre ciência e a religião cristã. Defenderemos que deve haver uma complementação entre ciência e religião, não devendo haver uma compartimentalização, sendo os dois campos de conhecimento que nos propiciam elementos importantes para chegarmos a única verdade de Deus. O artigo sugere uma conduta do cristão diante dos avanços científicos e como relacioná-las com as verdades eternas das Escrituras Sagradas. Para isso escolhemos como caso esquemático a polêmica entre Teoria da Evolução e Design Inteligente, que é uma polêmica atual. Através da análise mostramos um caso prático de como deve ser o posicionamento cristão diante de dados científicos que podem ser contraditórios e suas implicações para uma cosmovisão cristã. Por fim, concluímos que a ciência e a teologia devem estar unidas para promover o bem para a humanidade, e que assim como a ciência pode ajudar o teólogo, a teologia pode contribuir com o cientista, pois nenhum dos campos são completos em si.
Ética e sentido da vida: contribuições para a teologia no espaço público a partir de Clodovis Boff
Authors: Zeferino Jefferson
Published: July 2017

Em nossa análise buscamos uma aproximação crítica da elaboração de Clodovis Boff sobre o sentido da vida, relacionando-a com a assim chamada Teologia Pública. Assim, por meio da relação de fundo sobre ser e fazer – em um contexto de crises, com destaque para a crise existencial e, em consequência, crise ética e de valores – pensa-se uma ética pertinente ao contexto brasileiro, bem como a incidência pública de uma determinada práxis e espiritualidade cristãs.Palavras-chave: Clodovis Boff. Teologia Pública. Sentido da Vida. Espiritualidade. Ética.
On optimization of geodetic reference networks of accelerators using laser trackers
Authors: Murzincev P.P. , Polianskiy А.V. , Serdakov L.E.
Published: July 2017

The features of laser tracker measurements and their accounting for designing geodetic networks on the accelerator complexes are considered. The key parameters for the optimization of the spatial geodetic network of the accelerator are proposed. The dependence of average mean square errors on the radial and altitudinal directions of orientation of the sighting beam for distances from 1 to 30 meters was defined. The influence of the choice of stations for mounting the laser tracker to determine the parameters of the ellipsoid of errors was studied. The measurements for three variants of geodetic networks in the tunnel with the adopted geometric parameters were simulated. The data of the deviations of the points of the network radius, altitude relative to the project was indicated. The obtained results can be useful both at the design stage of geodetic network accelerator, and at the stage of installation of technological equipment.
The development of geophysical maps’new classification
Authors: Loginov D.S. , Krylov S.A.
Published: July 2017

At the present time, the common classification of geophysical maps is missing, which is a consequence of their long-term development of the geological mapping. The features of existing approaches to the definition of geophysical maps’ place among maps of natural phenomena and the limitations of existing lists of mapping themes were determined and identified in this article. New approaches to the classification of geophysical maps that take into account the completeness of their contents and the current state of geophysical mapping were offered. A new classification of geophysical maps was elaborated based on four criteria
The role of maps in regional geological museum
Authors: Astakhova I.S. , Zhdanova L.R.
Published: July 2017

The modern state of map collection of the A. A. Chernov Geological Museum of Institute of Geology of Komi Science Centre of the UB of the RAS is described. The collection is divided into the historic and expository parts. It has shown the geological and geographical maps of the European part of North-East of Russia starting to XV age till now. The features of cartographic material for understanding the history of the study and development of the territory are described. It highlights the role of cartographic material in the museum exposition in the study of the structural features of the earth's crust and mineral exploration. The problems of modern cartographic support of the museum are described and the requirements for maps are compiled. The modern cartographic material is an electronic maps and charts. It has shown the importance of the establishing of Regional Atlas for evaluating the history and the future development of the region.
Modelling and Simulation of a Microturbine during Transient Events
Authors: P. Eguia  , I. Zamora  , E. Torres  , J.I. San Martín  , M. Moya  , J.C. Bruno  , A. Coronas
Published: July 2017

This paper deals with the performance of a
microturbine connected to a LV grid during different transient
events in the network. The study is based on the dynamic
modelling of a microturbine and the simulation of different
events in the Matlab/Simulink environment.
The microturbine model has been validated with the
measurements taken in several test of a real 28kW Capstone
microturbine.
Analysis of the Spanish industry economical losses due to interruptions in the electricity supply
Authors: D. Coll-Mayor  , J. Pardo  , M. Pérez-Donsión
Published: July 2017

. This paper focuses on the evaluation of the
economic consequences of a lack of power quality in the
industrial sector. The term Power Quality includes, in general, a
set of boundary conditions which allow electrical systems
connected to the grid to function in their intended manner,
without significant loss of performance or life. Therefore, the
operation of the power system outside these boundaries directly
impacts on the economic performance of the whole system. The
evaluation of the economical loses derived of this fact has been
matter of several studies, mostly applied to individual cases,
with calculation methodologies either too complicated to be
applicable, either needing a large input of data most dealing
with confidentiality issues or either based on particular cases
and impossible to extrapolate. The methodology proposed in
this paper is relativelly easy to apply, covers a large range of
cases and is based on data directly retrieved from estatistics of
the Spanish government free downladable and free of
confidentiality issues. An example of the application of this
methodology and an analysis of the results is also provided.
Bundling of Power Quality Indices as Method for Correlating Load Susceptibility and Disturbances Superposition
Authors: P. Janik  , Z. Waclawek  , T. Lobos  , H. Amaris
Published: July 2017

This paper presents a neuro-fuzzy approach to
power quality assessment. Electrical equipment susceptibility to
disturbances varies from type to type. Additionally, not only
one physical phenomenon (e.g. harmonics) can cause
equipment malfunctioning or damage, but more likely a
superposition of some different disturbances. The authors
propose an automated neuro-fuzzy approach to power quality
indicia bundling which is correlated to equipment susceptibility.
Whereby distortion power is seen as one of the power quality
indices.
The neuro-fuzzy analyzer matches logically different indices
and gives as output one value describing the possible thread to
electrical equipment. A reduction of data amount to be analysed
by a system engineer is aimed.
VASCONCELLOS, Paulo Sérgio de. Persona Poética e autor empírico na poesia amorosa romana. São Paulo, Editora Unifesp, 2016, 248 p.
Authors: Marasco Franco Simone Sales
Published: July 2017

Resenha do livro de Paulo Sérgio Vasconcellos, Persona Poética e autor empírico, de 2016.
O panteão invisível: Breves notas sobre alguns papiros mágicos gregos
Authors: Viegas Rafael Marcelo
Published: July 2017

Este artigo apresenta questões introdutórias à leitura dos sete papiros de invisibilidade conhecidos, a partir da análise de algumas das divindades/entidades que constam nos feitiços. O apêndice traz duas traduções do material.
Towards better research and reporting
Authors: Baral Sushim Ranjan
Published: July 2017

No abstract
Vegetation analysis for the rehabilitation of red clay soils at Panchkhal, Kabhrepalanchok District
Authors: Baral Sushim R. , Malla Mrigendra B. , Howell John
Published: July 2017

Abstract on PDF
Application of satellite data: a case study of Sunsari district
Authors: Amatya Swoyambhu Man
Published: July 2017

No abstract available
Approaches to extension in forestry: experiences of community forestry in Nepal
Authors: Gautam K.H.
Published: July 2017

Abstract on PDF
Yield of Morus alba cuttings under different stool-bed regimes at Chalnakhel nursery
Authors: Thapa H.B.
Published: July 2017

No Abstract
Ethnobotanical study in a village at Rukum District, Nepal
Authors: Bhatta L.R.
Published: July 2017

The present study gives information on the indigenous use of various plants locally available at Vijayashori Village Development Committee (VDC) of Rukum District. Forty-four species have been reported to be used for various purposes that include medicine, food, furniture making, agricultural implements, etc.
A preliminary study of the pressure and shear stress on a plane surface beneath a circular cylinder in turbulent flow fields
Authors: Cai Jian-Chen , Pan Jie , E Shi-Ju , Jiao Wei-Dong , Wang Dong-Yun
Published: July 2017

This paper studies the fluctuating forces on a plane surface beneath a circular cylinder in the subcritical flow regime using two-dimensional computational fluid dynamics (CFD). The turbulent flow fields were calculated via numerical solutions of the NavierStokes (NS) equations without a turbulence model (laminar flow computation), large eddy simulation (LES), and Reynolds-Averaged N-S equations (RANS) approach with the shear-stress transport (SST) turbulence model. The primary goal is to evaluate the performance of 2-D turbulence simulation with different approaches and to have preliminary knowledge of the forces on the plane which is important in studying scours and flow-induced vibration in ocean engineering. Results show that although a coarse mesh scheme can only obtain potential flows, the laminar approach with high mesh resolution can adequately simulate turbulent flows at moderate Reynolds numbers. Spatially, the fluctuating forces on the plane surface due to the flow are significant within three times the cylinder diameter in the downstream, and within one cylinder diameter in the upstream of the cylinder. The pressure fluctuations are approximately two orders of magnitude larger than the shear stress fluctuations. In the frequency domain, the fluctuating forces are significant under twice the vortex-shedding frequency. Within one cylinder diameter in the downstream and upstream regions of the cylinder, the pressure fluctuations on the plane surface are well correlated, while the shear stress is not so well correlated.
Investigation of blood flow through an artery in the presence of overlapping stenosis
Authors: Prasad K. Maruthi , Thulluri S. , Phanikumari M. V.
Published: July 2017

The effects of an overlapping stenosis on blood flow characteristics in an artery have been studied. Blood has been represented by a couple stress fluid. The flow equations have been linearised and the expressions for pressure drop, resistance to the flow and wall shear stress have been derived. The results are shown graphically. It is observed that the resistance to the flow, pressure drop and wall shear stress increases with height and length of the stenosis. And it is noticed that the resistance to the flow and pressure drop decreases with couple stress fluid parameters. But wall shear stress increases with couple stress fluid parameters.
CLIC1 Induces Drug Resistance in Human Choriocarcinoma Through Positive Regulation of MRP1
Authors: Wu Jinhui , Wang Dongshuang
Published: July 2017

Chemotherapy is typically used to treat choriocarcinoma. However, a small proportion of this malignancy develops resistance to common chemotherapeutic drugs such as methotrexate (MTX) and floxuridine (FUDR). This study aimed to investigate the role and potential mechanisms of chloride intracellular channel protein 1 (CLIC1) in the development of chemoresistance in choriocarcinoma JeG3 cells. Two chemoresistant sublines were induced from their parental cell line JeG3 through intermittent exposure to MTX (named JeG3/MTX) or FUDR (named JeG3/FUDR). It was found that expression of CLIC1 was significantly higher in the chemoresistant sublines JeG3/MTX and JeG3/FUDR than in their parental cell line JeG3. Knockdown of CLIC1 by specific siRNA significantly increased cell sensitivity to MTX and FUDR in vitro and in vivo. Moreover, the high expression of CLIC1 in chemoresistant sublines was associated with upregulation of multidrug resistance-associated protein 1 (MRP1). Knockdown of CLIC1 decreased the expression of MRP1 accordingly. While reexpression of CLIC1 in the parental cell JeG3 increased its resistance to MTX and FUDR, depletion of MRP1 significantly blunted CLIC1 reexpression-mediated acquirement of chemoresistance in JeG3 cells. In conclusion, our results suggest that CLIC1 may serve as a critical mediator of chemoresistance in human choriocarcinoma JeG3 cells. The CLIC1-mediated chemoresistance is achieved through positive regulation of MRP1. Depletion of either CLIC1 or its downstream MRP1 may be a promising therapeutic strategy concerning reversing the chemoresistance in human choriocarcinoma JeG3 cells.
Risk Factors Related To The Psychic Suffering In Women In Pre And Post-Natal Accompanied By An Institution Of Philanthropic Pernambuco State
Authors: Da Silva Liniker Scolfild Rodrigues , Correia Nathália Da Silva , Cordeiro Eliana Lessa , Ramos Ana Raquel Xavier , Cassilhas Ana Paula Pimentel , De Souza Gardênia Conceição Santos , Da Silva Ana Caroline Alves , Pimenta Clarissa Silva , Da Silva Filho Jabiael Carneiro , De Albuquerque Thaíse Torres , Da Silva Filho Ivanildo Pereira , Dos Santos Raquel Bezerra , Wanderley Thyago Da Costa , Lima Ítala Santos , Monteiro Erika Maria De Lima , Santos Ana Paula Ochoa , De Araújo Patricia Daniella , De Oliveira Ágda Caroenna Barros , Marques Maria Clara Vieira , Dos Santos Flavyana Silva , Da Silva Isabela Najela Nascimento , Castro Graciely Maria De Oliveira , Batista Morganna Guedes , Braga Luanna Silva , De Abreu Paula Daniella , Ribeiro Denize Ferreira
Published: July 2017

This article aims to identify the prevalence of women who present risk for psychological distress in the pre- and postnatal period. A descriptive, exploratory study was conducted with a quantitative data approach, a study carried out at the pre and postnatal health outpatient clinic of IMIP - Instituto de Medicina Integral Prof. Fernando Figueira, Recife (PE). We used instruments such as the Sociodemographic Data Survey Questionnaire, the Puerperal Pregnancy Cycle Questionnaire Questionnaire, and the Psychiatric Morbidity Questionnaire in Adults (QMPA) with 775 women, of whom 450 were pregnant and 325 were women who had given birth in the period of August / October 2014, After approval of the Ethics and Research Committee (CEP) of IMIP, under the number of CAEE: 30991314.9.0000.5201. The study showed that, in prenatal care, 48% (216) of the cases presented a risk for psychological distress; And in the postnatal period, 47% (152). It was possible to identify psychic suffering in the majority of women, and they often go unnoticed by the professionals who assist them. The knowledge of the risk factors, triggers and symptoms during the pregnancy-puerperal cycle, makes the mental diagnosis more efficient, thus providing a safer and more peaceful pregnancy for mother-child-family.

Keywords: Women’s Health; Mental Health; Stress Psychological; Risk Factors.
Evaluation of in-house loop-mediated isothermal amplification for tuberculosis diagnosis compared with Xpert MTB/RIF
Authors: Habeenzu Charity , Nakajima Chie , Solo Eddie , Bwalya Precious , Kajino Kiichi , Miller Mari , Kurosawa Youichi , Mudenda Victor , Kasonka Lackson , Suzuki Yasuhiko , Matsuba Takashi
Published: July 2017

Introduction: To evaluate the diagnostic performances of an in-house loop-mediated isothermal amplification (LAMP) kit and the Xpert MTB/RIF test for the diagnosis of pulmonary tuberculosis in a resource-limited setting, this study was performed at the University Teaching Hospital, Ministry of Health, the Republic of Zambia.

Methodology: Two hundred sputum specimens obtained from new tuberculosis (TB) suspects were used for the evaluation of the diagnostic performance of an in-house LAMP kit in comparison with the Xpert MTB/RIF kit.

Results: The sensitivity of in-house LAMP and Xpert MTB/RIF was 96.9% and 95.4% in smear-positive samples, 96.8% and 100% in smear-positive/culture-positive samples, and 39.1% and 73.9% in smear-negative/culture-positive samples, respectively. The specificity of in-house LAMP and MTB/RIF kits with culture was 96.5% and 94.5%, respectively. This indicated the superiority of the Xpert MTB/RIF kit; however, mechanical errors during sample processing and the insufficient quantity of samples by Xpert MTB/RIF kit occurred at 2.0% and 19.7%, respectively, comparing to the 100% accessibility of in-house LAMP.

Conclusions: Considering the results obtained in this study together with the easy setup with much simpler equipment, such as an aluminum heat block or water bath, in in-house LAMP compared with real-time polymerase chain reaction equipment in Xpert MTB/RIF kit, the applicability of in-house LAMP for the screening of tuberculosis directly from sputum in resource-limited setting seemed to be high.
In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis
Authors: Zandhaghighi Mehdi , Hadizadeh Farzin , Soleimanpour Saman , Meshkat Zahra , Rezaee Seyed Abdolrahim , Derakhshan Mohammad , Ghazvini Kiarash
Published: July 2017

Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total of 113 different strains of Mycobacterium tuberculosis (77 susceptible and 36 resistant clinical isolates).

Methodology: The in vitro activities of these compounds were evaluated based on the modified broth macro-dilution assay.

Results: Compound F-27 showed more than 90% growth inhibition at the range of 2 to 8 μg/mL (minimum inhibitory concentration [MIC]90: 4.13 ± 0.45 µg/mL; p  < 0.01), and complete growth inhibition was observed at the range of 8 to 32 μg/mL (minimum bactericidal concentration [MBC]: 11.2 ± 1.65 µg/mL; p < 0.01) against susceptible strains. However, 92% of the resistant strains showed some degree of susceptibility against this compound (MIC90 range: 16 to 64 µg/mL; mean: 40.4 ± 8 µg/mL; p < 0.01). It was found that although there is a linear relationship between the inhibitory activity of F-27 and isoniazid against resistant strains at low concentrations (r = 0.484, p < 0.001), there was no relationship between resistance to isoniazid and F-27 at higher concentrations (r = 0.019, p > 0.1). This may emphasize no cross-resistance between F-27 and isoniazid.

Conclusions: Considering the sufficient sample size of the study and based on the excellent antimycobacterial activity of F-27, it could be concluded that F-27 is a potent candidate as a lead compound, and may be considered for development of a new antitubercular agent.
Rodents and other small mammal reservoirs in plague foci in northeastern Brazil
Authors: Da Costa Erika de Cássia Vieira , Sobreira Marise , Leal Nilma Cintra , De Almeida Alzira Maria Paiva
Published: July 2017

Introduction: Plague is an acute, infectious zoonotic disease, primarily of wild rodents and their fleas, that affects humans and other mammals. In Brazil, several plague foci are located in the northeast region. Plague surveillance based on monitoring of rodents was discontinued in 2007, and the current information on rodent populations is unsatisfactory. Our purpose was to update the information on rodents and other small mammals in plague foci in northeastern Brazil.

Methodology: Nine surveys in the historically most important northeastern plague areas were conducted in 2013-2015.

Results: In this study, 393 animals (13 rodent and four marsupial species) were entrapped. The plague bacterium Yersinia pestis was not detected in tissue sample cultures from the 225 animals that were analyzed. Eighty sera samples were analyzed for anti-F1 antibodies by hemagglutination (HA) and protein A ELISA tests, and all were negative, except for one marsupial, Monodelphis domestica, which was HA positive.

Conclusions: Qualitative and quantitative differences in the animal populations were observed in the areas surveyed, and the antibody positive marsupial indicated that plague continues to circulate in the wild.
Detection of virulence genes in ESBL producing, quinolone resistant commensal Escherichia coli from rural Indian children
Authors: Chandran Salesh P , Sarkar Samarpita , Diwan Vishal , Pathak Ashish , Shah Harshada , Tamhankar Ashok J , Macaden Ragini , Stålsby-Lundborg Cecilia
Published: July 2017

Introduction: Extended-spectrum β-lactamase producing commensal Escherichia coli are considered as a reservoir of antibiotic resistance genes that may be transmitted in the community. This study aimed to determine the genes coding for ESBLs, plasmid mediated quinolone resistance and virulence markers in commensal E. coli isolated from healthy school children.

Methodology: ESBL producing E. coli isolates (n = 47) were obtained from 529 fecal samples of healthy school children from a rural area in central India. Multiplex PCR was used to detect the genes coding for cephalosporin and quinolone resistance, for virulence fluA, fluB, stx1, stx2, eae, bfp, lt, stII, virF, ipaH, daaE, aafII and phylogenetic groups.

Results: Of the 47 ESBL producing E. coli, 41 were positive for CTXM-15, 23 for TEM-1, 8 for OXA-1and a single for SHV-12. For plasmid-mediated quinolone resistance, all the 47 isolates carried the aac(6’)-ib-cr gene, and amongst them18 were qnrS positive. Virulence gene, fluA was detected in 32,whereas eae in 14, daaE in 7 and fluB in 1. In 10 isolates, fluA and eae and in 7, fluA and daaE co-existed. Of the 47 E. coli isolates, 18 were grouped into the phylogenetic group B2, 17 in D and 12 in A. The proportion of isolates positive for fluA gene in the phylogenetic group B2 (18/18), was significantly higher than in group A (7/12) and D (6/17).

Conclusion: Commensal E. coli in healthy children in rural India may serve as reservoirs of resistance towards cephalosporins and fluoroquinolones and virulence coding genes for urinary tract and diarrheal infections.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates from a university hospital in Brazil
Authors: Vivan Ana Carolina Polano , Rosa Juliana Ferraz , Rizek Camila Fonseca , Pelisson Marsileni , Costa Silvia Figueiredo , Hungria Mariangela , Kobayashi Renata , Vespero Eliana Carolina
Published: July 2017

Introduction: The emergence of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae (KPC-Kpn) isolates is attracting significant attention in nosocomial infection settings. K. pneumoniae is the main pathogen that harbours blaKPC genes.

Methodology: This study evaluated 54 K. pneumoniae carbapenem-resistant isolates from patients hospitalized at the University Hospital of Londrina, between July 2009 and July 2010. The isolates were phenotypically screened for carbapenemase production and submitted for genotypic confirmation by polymerase chain reaction (PCR) for KPC, metallo-β-lactamases, OXA-48, and extended-spectrum beta-lactamase genes. The absence of outer membrane proteins (OMP) was investigated by SDS-PAGE. The susceptibility profile was determined by broth microdilution, according to Clinical and Laboratory Standards Institute protocol.

Results: All isolates were phenotypically positive for class A carbapenemase production, but negative for metallo-β-lactamase activity. PCR analysis demonstrated that all isolates carried blaKPC genes and sequencing showed that all strains belonged to KPC-2 subtype. Four strains did not show porin expression, and all isolates were resistant to ertapenem, meropenem, and imipenem. Susceptibility rates reached 35.2% for gentamicin, 85.2% for polymixyn B, 87% for colistin, and 98.1% for both tigecycline and fosfomycin. Pulsed-field gel electrophoresis showed six clones, and three of them predominated among the isolates.

Conclusions: KPC-2-producing K. pneumoniae is becoming predominant among carbapenem-resistant K. pneumoniae isolates at the hospital. The association of the enzyme KPC with other resistance determinants, such as loss of porins, may increase the severity of the situation of nosocomial infections. There is an urgent need to develop strategies for infection control and prevention.
Critical points and the presence of pathogenic bacteria in iced beverage processing lines
Authors: Nababan Halim , Rahayu Winiati Pudji , Waturangi Diana Elizabeth , Suratmono Suratmono , Puspitasari Rina , Indrotristanto Nugroho , Nikastri Eva , Yuliangsih Suci , Pusparini Novi
Published: July 2017

Introduction: Ice can be contaminated by pathogenic bacteria. This study aimed to identify critical points in iced beverage production and distribution lines to examine the presence of pathogenic bacteria in a beverage and its processing environment, as well as when water and ice used as main ingredients.

Methodology: The critical points were determined using the principles of Hazard Analytical Critical Control Point (HACCP) to analyze each processing and distribution step from the survey. Samples collected from the points of concern based on the critical points that were found were tested for pathogens by conventional method and molecular method using primers and polymerase chain reaction (PCR).

Results: Escherichia coli was found in 6.34% of samples, and 0.7% of them were confirmed as enterotoxigenic Escherichia coli (ETEC) by PCR. Vibrio cholerae was found in in 0.7% of water samples used to make iced beverages and in ice production, as well as in 2.12% of distribution and production tools. Salmonella Typhimurium was found in 1.4% of water samples used to make ice and ice products. Staphylococcus aureus was found in 2.02% of the surfaces of ice distribution and production tools and in 5.05% of production and distribution workers’ hands. S. aureus counts ranged from 2.4×102 - 3.5×102 colonies/100 cm² surface area and 1.9×10¹ - 3.7×102 colonies/workers’ hands.

Conclusion: Control on many critical points in iced beverage processing and distribution is required so that the beverages are safe for consumption.
A Study of Micro-Arc Oxidation Coatings on Aluminum Alloy Drill Pipe for Offshore Platform
Authors: Shen Yan , Sahoo Prasanta K. , Pan Yipeng
Published: July 2017

AbstractIn order to enhance the corrosion resistance of a drill pipe for an offshore platform, micro-arc oxidation (MAO) coatings were deposited on the surface of an aluminum alloy drill pipe by MAO technology. The microstructure and anticorrosion performance of the MAO coatings
were investigated experimentally. This paper mainly focuses on the experimental work to determine the influence of cathode voltage on the structural characteristics and corrosion resistance of MAO coatings. The results show that the cathode voltage has a significant effect on the preparation
of MAO coating during the process. The surface of the coating becomes more compact and smooth with the increase of the cathode voltage. Furthermore, the anticorrosion performance of MAO coatings can effectively be improved with the increase of cathode voltage.
Chinese Journey to the Challenger Deep: The Development and First Phase of Sea Trial of an 11,000-m Rainbowfish ARV
Authors: Cui Weicheng , Hu Yong , Guo Wei
Published: July 2017

AbstractThe remoteness and isolation of hadal zone environments make this region of inner space a particularly fertile field for scientific inquiry. After the successful development of the 7,000-m class deep manned submersible Jiaolong, the Chinese government and scientists
have recognized the necessity to develop deep submergence vehicles up to 11,000 m depth. In this paper, a unique Chinese journey to the Challenger Deep is described. The whole project is to construct a movable laboratory that includes a mothership, three full ocean depth landers, a hybrid
autonomous and remotely operated vehicle (ARV), and a human occupied vehicle (HOV). A three-phase approach is adopted for this project. Phase I is the completion of 4,000-m class sea trials of the first lander and the ARV with a temporary ship. Phase II is the completion of 11,000-m sea trials
of the three landers and the ARV with the newly built mothership. Phase III is the completion of 11,000-m sea trials of the HOV with the same permanent mothership. In order to overcome the funding issue, a multiple investment method was introduced in this project. The basic idea is that the
funding for the ARV and three landers will be sought from university sources and local government, the funding for the mothership will be sought from private investors, and only the manned submersible will seek support from the central government. To the authors' knowledge, this may be the
first attempt in China to carry out a project with private investment as a supplement to governmental funding. The project has progressed very well over the past 3 years and has proven that this funding strategy is working. In this paper, the progress of the whole project is briefly introduced,
while the focus is on the description of the design details of the Rainbowfish ARV including the results of the first phase of sea trials. The ARV planned to perform its 11,000-m class sea trial at the end of 2016.
A Simple Gold Nanoprobe Assay for the Identification of Staphylococcus Aureus, Listeria Monocytogenes and Salmonella Enteritidis in Food Specimens
Authors: Houhoula Dimitra Panagiotis , Charvalos Ekatherina , Konteles Spyros , Koussissis Stamatis , Lougovois Vladimiros , Papaparaskevas Joseph
Published: July 2017

In the present study, we developed a gold nanoprobe assay, which relies on the colorimetric differentiation of specific DNA sequences, based on different aggregation profiles. We evaluated the assay on DNA extracted from pathogen cultures and from contaminated food specimens. The targets used were the femA gene for the identification of Staphylococcus aureus, the hly gene of the Listeria monocytogenes listeriolysin and the invA sequence for Salmonella spp. Comparison was performed with the reference assay, as described in the respective ISO guidelines for each pathogen, and a direct PCR amplification and detection. The minimum detection limit of the assay was defined at 123 fg/μL DNA, for all species, lower than PCR detection. Specificity was 100%. Sensitivity was 100%, as compared το the reference method, whereas the sensitivity of PCR was 93.3%. The evaluated assay could be used as a sensitive screening method, which does not require major infrastructure, for the detection and identification of pathogens in food specimens. In addition, it can accommodate detection of multiplespecies,thus allowing multiplexingand expedite turnaround time.
A precariedade existencial como condição essencial de compreensão para a experiência religiosa na contemporaneidade
Authors: Toledo Daniel
Published: July 2017

O presente artigo versa sobre a referência ontológica de fundo da experiência religiosa em geral e tem como objetivo evidenciar em que medida a nossa condição existencial de finitude é impositiva para se compreender as mais variadas formas de manifestações dos fenômenos religiosos que afloram na contemporaneidade. Para isso, partiremos da distinção entre uma concepção hermenêutico-fenomenológica da experiência religiosa em sua essência e as abordagens empíricas acerca das suas diversas configurações concretas. Ao cabo, tentaremos apontar que as possibilidades de apreensão dos fenômenos religiosos em geral são devedoras de um elemento existencial que nos é essencialmente constitutivo, a saber, a condição de precariedade do ser finito diante da abertura de sentido que o excede em seu horizonte de transcendência. Como contribuição geral, essa forma de compreensão apresentada deve vedar toda pretensão de tornar absoluto um sentido de fundo que deve permanecer em aberto enquanto a mais radical condição de possibilidade para o fenômeno religioso.
Management of Polypoid Gallbladder Lesions in Children: A Multicenter Study
Authors: Binet Aurélien , Varlet François , Baudry Manon , Dubois Rémi , Héry Géraldine , Podevin Guillaume , Abbo Olivier , Arnaud Alexis , Barras Marc , Guerin Florent , Reinberg Olivier , Piolat Christian , Fourcade Laurent , Ballouhey Quentin
Published: July 2017

Introduction Polypoid lesions of the gallbladder (PLG) are relatively common in adults, while they are very rare in children. The use of high-quality ultrasonography leads to increased detection of PLG, although less than 20 pediatric cases of primary PLG have been reported in the literature. The aim of this study was to address the experience of PLG management in children.

Materials and Methods A retrospective multicenter review of children with ultrasonographically defined PLG between 2006 and 2016 was performed. The data from 12 pediatric surgery centers were compiled for this purpose.

Results Eighteen patients (mean age: 10.4 ± 4.1 years) were included and managed according to each center's protocols. Cholecystectomy was performed for nine symptomatic patients. Histopathology conclusively revealed four tubular and five papillary adenomas, with a median size of 12 mm (ranging from 3 to 35 mm). Nine asymptomatic children were monitored by sonography over a 24-month (ranging from 12 to 66 months) follow-up period. The median PLG size was 7 mm (ranging from 3 to 9 mm). Two lesions disappeared after 1 and 2 years of follow-up, respectively. None of the patients developed symptoms or malignant transformation.

Conclusion This report confirms appropriate use of a conservative approach with annual clinical and ultrasound follow-up for small-sized and isolated PLG in children given the absence of malignancy and potential vanishing entities. Surgical treatment should be considered in case of lesions larger than 10 mm in size or when they are associated with symptoms.
Acquisition of Borrelia burgdorferi Infection by Larval Ixodes scapularis (Acari: Ixodidae) Associated With Engorgement Measures
Authors: Couret J. , Dyer M. C. , Mather T. N. , Han S. , Tsao J. I. , Lebrun R. A. , Ginsberg H. S.
Published: July 2017

Measuring rates of acquisition of the Lyme disease pathogen, Borrelia burgdorferi sensu lato Johnson, Schmid, Hyde, Steigerwalt & Brenner, by the larval stage of Ixodes scapularis Say is a useful tool for xenodiagnoses of B. burgdorferi in vertebrate hosts. In the nymphal and adult stages of I. scapularis, the duration of attachment to hosts has been shown to predict both body engorgement during blood feeding and the timing of infection with B. burgdorferi. However, these relationships have not been established for the larval stage of I. scapularis. We sought to establish the relationship between body size during engorgement of larval I. scapularis placed on B. burgdorferi-infected, white-footed mice (Peromyscus leucopus Rafinesque) and the presence or absence of infection in larvae sampled from hosts over time. Body size, time, and their interaction were the best predictors of larval infection with B. burgdorferi. We found that infected larvae showed significantly greater engorgement than uninfected larvae as early as 24 h after placement on a host. These findings may suggest that infection with B. burgdorferi affects the larval feeding process. Alternatively, larvae that engorge more rapidly on hosts may acquire infections faster. Knowledge of these relationships can be applied to improve effective xenodiagnosis of B. burgdorferi in white-footed mice. Further, these findings shed light on vector–pathogen–host interactions during an understudied part of the Lyme disease transmission cycle.
Dynamic expression of tRNA-derived small RNAs define cellular states
Authors: Yim Daniel GR , Krishna Srikar , Lakshmanan Vairavan , Koh Judice LY , Park Jung Eun , Cheong Jit Kong , Low Joo Leng , Lim Michelle JS , Junyu IP , Nah Jie Min , Tan Iain BH , Iyer N Gopalakrishna , Guo Huili , Sze Siu Kwan , Raghavan Srikala , Palakodeti Dasaradhi , Dasgupta Ramanuj
Published: July 2017

Transfer RNA (tRNA)-derived small RNAs (tsRNAs) have recently emerged as important regulators of protein translation and shown to have diverse biological functions. However, the underlying cellular and molecular mechanisms of tsRNA function in the context of dynamic cell-state transitions remain unclear. Here we report the identification of a set of tsRNAs upregulated in differentiating mouse embryonic stem cells (mESCs). Mechanistic analyses revealed primary functions of tsRNAs in regulating polysome assembly and translation. Notably, interactome studies with differentially-enriched tsRNAs revealed a switch in associations with ‘effector’ RNPs and ‘target’ mRNAs in different cell-states. We also demonstrate that a specific pool of tsRNAs can interact with Igf2bp1, an RNA-binding protein, to influence the expression of the pluripotency-promoting factor-c-Myc, thereby providing evidence for tsRNAs in modulating stem cell-states in mESCs. Finally, tsRNA expression analyses in distinct, heterologous cell and tissue models of stem/transformed versus differentiated/normal states reveal that tsRNA-mediated regulation of protein translation may represent a global biological phenomenon associated with cell-state transitions.

One Sentence Summary

Identification and functional characterization of tRNA-derived small RNAs (tsRNAs) in cell state switches.
Left ventricular diverticulum mimicking cardiac tumor
Authors: Wybraniec Maciej T. , Wróbel Wojciech , Myszor Jarosław , Mizia‐Stec Katarzyna
Published: July 2017

Left ventricular (LV) diverticulum represents a rare and frequently asymptomatic congenital anomaly, which is incidentally discovered during routine transthoracic echocardiography. We present a case of a 66‐year‐old female patient who was admitted to the cardiology department due to incidental finding of a tumor‐like mass associated with the posterior mitral leaflet. Preliminary echocardiographic evaluation revealed a solid structure, suspected of mitral annulus calcification or LV malignancy. However, cardiac contrast‐enhanced computed tomography confirmed the presence of LV diverticulum, partially filled with calcified thrombus. Conservative management was recommended. This case underscores the importance of multimodality imaging for differentiation of LV tumor‐like structures.
Efficacy and Safety of Topical Corticosteroids for Management of Oral Chronic Graft versus Host Disease
Authors: Elsaadany Basma Abdelaleem , Ahmed Eman Magdy , Aghbary Sana Maher Hasan
Published: July 2017

Background. Oral chronic graft versus host disease (cGVHD) is a major complication in transplantation community, a problem that can be addressed with topical intervention. Topical corticosteroids are the first line of treatment although the choice remains challenging as none of the available treatments is supported by strong clinical evidence. Objective. This systematic review aims to determine the clinical efficacy and safety of topical corticosteroids for the management of the mucosal alterations of oral cGVHD. Data Sources. Electronic search of different databases was conducted: PubMed, Cochrane library, Grey literature, WHO, and clinical trials.gov for clinical trial registration as well as hand search in the references of relevant articles up to November 2016. Data Extraction. Extracted pieces of information were intervention, population, sample sizes, and outcomes. Data Synthesis. Six studies were included: 2 randomized clinical trials (RCTs), 3 cohort studies, and 1 pre-post clinical trial. Results. There is a limited evidence concerning clinical efficacy of topical corticosteroids. Clobetasol, dexamethasone, and budesonide were the topical corticosteroid of choice. The highest level of evidence score was given to clobetasol followed by budesonide with a lower evidence level. Conclusion. All three topical corticosteroid preparations are effective for management of oral chronic GVHD with minimal easily avoided side effects.
Investigation into the Heat of Hydration and Alkali Silica Reactivity of Sustainable Ultrahigh Strength Concrete with Foundry Sand
Authors: Aguayo Federico , Torres Anthony , Talamini Tate , Whaley Kevin
Published: July 2017

This study presents the hydration reactivity and alkali silica reaction (ASR) of ultrahigh strength concrete (UHSC) that has been made more sustainable by using spent foundry sand. Spent foundry sand not only is sustainable but has supplementary cementitious material (SCM) characteristics. Two series of UHSC mixtures were prepared using a nonreactive and reactive sand (in terms of ASR) to investigate both the impact of a more reactive aggregate and the use of spent foundry sand. Conduction calorimetry was used to monitor the heat of hydration maintained under isothermal conditions, while ASR was investigated using the accelerated mortar bar test (AMBT). Additionally, the compressive strengths were measured for both series of mixtures at 7, 14, and 28 days to confirm high strength requirements. The compressive strengths ranged from 85 MPa (12,345 psi) to 181.78 MPa (26,365 psi). This result demonstrates that a UHSC mixture was produced. The calorimetry results revealed a slight acceleration in the heat of hydration flow curve compared to the control from both aggregates indicating increased hydration reactivity from the addition of foundry waste. The combination of foundry sand and reactive sand was found to increase ASR reactivity with increasing additions of foundry sand up to 30% replacement.
Application of Multiple-Population Genetic Algorithm in Optimizing the Train-Set Circulation Plan Problem
Authors: Zhou Yu , Zhou Leishan , Wang Yun , Yang Zhuo , Wu Jiawei
Published: July 2017

The train-set circulation plan problem (TCPP) belongs to the rolling stock scheduling (RSS) problem and is similar to the aircraft routing problem (ARP) in airline operations and the vehicle routing problem (VRP) in the logistics field. However, TCPP involves additional complexity due to the maintenance constraint of train-sets: train-sets must conduct maintenance tasks after running for a certain time and distance. The TCPP is nondeterministic polynomial hard (NP-hard). There is no available algorithm that can obtain the optimal global solution, and many factors such as the utilization mode and the maintenance mode impact the solution of the TCPP. This paper proposes a train-set circulation optimization model to minimize the total connection time and maintenance costs and describes the design of an efficient multiple-population genetic algorithm (MPGA) to solve this model. A realistic high-speed railway (HSR) case is selected to verify our model and algorithm, and, then, a comparison of different algorithms is carried out. Furthermore, a new maintenance mode is proposed, and related implementation requirements are discussed.
Simplified Qualitative Discrete Numerical Model to Determine Cracking Pattern in Brittle Materials by Means of Finite Element Method
Authors: Ochoa-Avendaño J. , Garzon-Alvarado D. A. , Linero Dorian L. , Cerrolaza M.
Published: July 2017

This paper presents the formulation, implementation, and validation of a simplified qualitative model to determine the crack path of solids considering static loads, infinitesimal strain, and plane stress condition. This model is based on finite element method with a special meshing technique, where nonlinear link elements are included between the faces of the linear triangular elements. The stiffness loss of some link elements represents the crack opening. Three experimental tests of bending beams are simulated, where the cracking pattern calculated with the proposed numerical model is similar to experimental result. The advantages of the proposed model compared to discrete crack approaches with interface elements can be the implementation simplicity, the numerical stability, and the very low computational cost. The simulation with greater values of the initial stiffness of the link elements does not affect the discontinuity path and the stability of the numerical solution. The exploded mesh procedure presented in this model avoids a complex nonlinear analysis and regenerative or adaptive meshes.
Gene Expression and Molecular Characterization of a Xylanase from Chicken Cecum Metagenome
Authors: AL-Darkazali Hind , Meevootisom Vithaya , Isarangkul Duangnate , Wiyakrutta Suthep
Published: July 2017

A xylanase genexynAMG1with a 1,116-bp open reading frame, encoding an endo-β-1,4-xylanase, was cloned from a chicken cecum metagenome. The translatedXynAMG1protein consisted of 372 amino acids including a putative signal peptide of 23 amino acids. The calculated molecular mass of the matureXynAMG1was 40,013 Da, with a theoretical pI value of 5.76. The amino acid sequence ofXynAMG1showed 59% identity to endo-β-1,4-xylanase fromPrevotella bryantiiandPrevotella ruminicolaand 58% identity to that fromPrevotella copri.XynAMG1has two conserved motifs, DVVNE and TEXD, containing two active site glutamates and an invariant asparagine, characteristic of GH10 family xylanase. ThexynAMG1gene without signal peptide sequence was cloned and fused with thioredoxin protein (Trx.Tag) in pET-32a plasmid and overexpressed inEscherichia coliTuner™(DE3)pLysS. The purified matureXynAMG1was highly salt-tolerant and stable and displayed higher than 96% of its catalytic activity in the reaction containing 1 to 4 M NaCl. It was only slightly affected by common organic solvents added in aqueous solution to up to 5 M. This chicken cecum metagenome-derived xylanase has potential applications in animal feed additives and industrial enzymatic processes requiring exposure to high concentrations of salt and organic solvents.
Sertoli-Leydig Cell Tumor with Concurrent Rhabdomyosarcoma: Three Case Reports and a Review of the Literature
Authors: Plastini Trisha , Staddon Arthur
Published: July 2017

Sertoli-Leydig Cell Tumors (SLCTs) make up <1% of all ovarian tumors and are benign or malignant, androgen-secreting tumors. Rhabdomyosarcoma (RMS) is a heterogeneous group of malignant tumors that resemble developing skeletal muscle. There have been case reports of patients with concurrent SLCT and RMS with limited treatment options. We aim to demonstrate treatment strategies used in our patients, which seemed to have prolonged survival when compared to prior case reports of patients not cured by surgical resection. Herein we describe 22 cases of SLCT with RMS elements as discussed in prior case reports and three cases from the authors’ institution. Of the 19 cases from prior case reports, five were lost to follow-up and two had NED after surgical intervention. Eleven patients had recurrence and were deceased within one year. Of those patients not surgically cured, only three patients were documented as living beyond two years, all of whom received chemotherapy. The three patients presented from our institution had clinical evidence of response to chemotherapy that is traditionally used for RMS. In conclusion, chemotherapy with doxorubicin and ifosfamide has activity in patients with SLCT and RMS as does salvage chemotherapy with vincristine, irinotecan, and temozolomide.