bluuebunny/crossref_metadata_2025 huggingface dataset:
Комбінована терапія артеріальної гіпертензії із застосуванням бета-блокаторів згідно з сучасними рекомендаціями
Authors: Lazariev P.O.
Published: November 2022

У статті розглянуті основні сучасні підходи до комбінованої терапії артеріальної гіпертензії із застосуванням β-блокаторів. Наведений перелік клінічних ситуацій, у яких β-блокатори застосовуються з першого кроку. Розглянуте питання застосування β-блокаторів із дигідропіридиновими блокаторами кальцієвих каналів тривалої дії з акцентом на комплементарну дію. Через ризик атріовентрикулярної блокади та брадикардії поєднання недигідропіридинових блокаторів кальцієвих каналів та β-блокаторів не рекомендується. Спільне призначення β-адреноблокаторів та діуретиків на початковому етапі не є кращою комбінацією при неускладненій артеріальній гіпертензії. Але існують певні клінічні ситуації, коли слід розглянути одночасне застосування цих двох класів препаратів. При цьому перевага надається вазодилатуючим препаратам як таким, що не мають дисметаболічної дії. Використання блокаторів ренін-ангіотензинової системи як початкової комбінованої терапії з більшістю β-блокаторів не рекомендується через недостатню антигіпертензивну ефективність. Бета-блокатор небіволол, що має додатковий вазодилатуючий механізм дії, може застосовуватися разом із блокаторами ренін-ангіотензинової системи й забезпечувати адекватний для подвійної терапії контроль артеріального тиску.
THE PANDEMIC WORLD OF COVID-19 IN EUROPE: POLITOLOGICAL REFLECTION ON STATE OF EXCEPTION IN SELECTED COUNTRIES FROM THE PERSPECTIVE OF SOCIAL POLICY MODELS
Authors: Bujvid Kurek Eva , Rybak Karolina
Published: November 2022

The state of exception is implemented to protect the security of citizens and public order. During that time the human rights become limited in favor of public authorities. In the face of the COVID-19 pandemic, only some countries in Europe have declared a state of exception. It is worth to consider what caused this decision. The aim of this article is therefore to determine whether and to what extent a specific model of social policy dominating in the state had an impact on the steps taken to combat the COVID-19 pandemic, and above all whether it determined the implementation of a state of exception. The concept created and developed by many researchers, among the others Bogusław Jagusiak became the background for the considerations. He classified and defined the existing forms of social policy, putting them in the framework of models. The starting point for this research was the typology proposed by Gøst Esping-Andersen. This concept has been developed and the following models have been distinguished: Nordic, Anglo-Saxon, Continental, Mediterranean and Post-Communist. According to the above distinction, five countries that that represent a specific model of social policy to the greatest extent will be selected. For the Nordic, Anglo-Saxon, Continental, Mediterranean and Post-Communist models, these will be Sweden, Great Britain, Germany, Italy and Poland. Then they will be subjected to comparative studies in relation to the issues described above.
POPULISM DURING THE COVID-19 PANDEMIC IN THE WESTERN BALKANS
Authors: Agolli Viorela
Published: November 2022

This paper aims to develop an analysis of how the Covid-19 pandemic influenced populist trends in the Western Balkan countries. Covid-19 pandemic impacted many sectors within the states themselves including health, economy, education, etc. and it produced even greater challenges at an international level. By focusing in the Western Balkans area, the paper focuses on the political system, and more specifically on how the political leadership through specific decision-making processes during the pandemic affected the presence or increase of populistic trends. Thus, by focusing into specific decision-making dynamics of the political leadership in the Western Balkan countries, through the use of qualitative and secondary quantitative data, the paper develops an in-depth elaboration on the presence of populism in this area. What is more, the paper addresses the general Covid-19 situation in these countries along with how the political leadership has dealt with the pandemic by further shedding light on the presence of populism and how the handling of the pandemic through specific political decisions emphasized these populistic trends.
PARLIAMENTARY ELECTIONS IN ALBANIA DURING THE COVID-19 PANDEMIC CIRCUMSTANCES THROUGH POLITICAL AND LEGAL LENSES
Authors: Berdufi Dorina , Kume Andon , Qejvani Olta
Published: November 2022

As one of the Balkan post-communist countries, Albania faces different hindering factors in the process of constituting election’s democracy. In the parliamentary election of April 2021, Albania was challenged by an additional extraordinary obstacle, of holding parliamentary election during the Covid-19 pandemic circumstances. The Covid-19 pandemic restrictions imposed new realities to the electoral process, specifically in: development of electoral campaign, voting process, diaspora voting, voters with Covid-19, voting process in the penitentiary system and the new electoral reform placed in 2020. Therefore, through a mixed political and legal detailed analyses method of the above-mentioned factors, this paper’s aim is to respond to the research question of what the impact of Covid-19 restrictions in Albanian Parliamentary election of April 2021 is. Research data are mostly based on primary data, such as the political agreement, the legal acts of State Commissioner, Regulatory Commission, sanctions and appeals decisions and other related documents. We strongly stand that the new reality must not break in the fundamental principles of electoral process and related political actors’ rights.
The Effectiveness of a Vehicle Manufacturing Line Using Probabilistic Process Timing
Authors: Ahlawat Yogesh
Published: November 2022

Abstract: Automotive manufacturing involves several steps, starting with the casting of components and moving on to the machining and assembly processes. The assembly system, particularly for the Single Cylinder S.I. Engine, will be the only emphasis of this project. A considerable number of components must be integrated throughout the engine assembly process. The creation of a decision assistance system based on a discrete event simulation model is discussed in the work provided in this paper. The four closed-loop network arrangement of vehicle assembly and preassembly lines connected by conveyors is targeted at a particular type of manufacturing lines. The design and execution of such industrial processes frequently include simulation. This simulation research aims to select the process throughput for the Single Cylinder S.I. Engine Assembly line. Any possible machine bottlenecks will be identified by the simulation study to avoid blockages and starvation and increase process throughput. Machine cycle times for various processes should be included in the input data for the research. The Arena simulation program will be utilized in this investigation. The goal is to use existing equipment to boost output on the present Head Assembly Line and Sub-Assembly Lines to an anticipated capacity. The outcomes of the simulation will be used to pinpoint the assembly-line procedures that may have an impact on the S.I. Engine's manufacturing schedule. By contrast the study's findings with the actual process throughput, the findings will be illustrated. Additionally, statistical analysis will be done to boost performance.
Development and Characterization of Floating Microspheres of Dexrabeprazole Sodium for the Treatment of Peptic Ulcer
Authors: Sahu Ragini , Jain Sarang
Published: November 2022

Dexrabeprazole sodium (DEX) is R (+)-isomer of rabeprazole. DEX has been used in the treatment of gastroesophageal reflux disease by suppressing gastric acid secretion. It acts as a proton pump inhibitor of the H+ /K+ ATPase enzyme. The purpose of this research was to prepare a floating drug delivery system of DEX. The floating microspheres can be prepared for the improvement of absorption and bioavailability of DEX by retaining the system in the stomach for prolonged period of time. Floating microspheres of DEX were prepared using different polymers like ethyl cellulose, hydroxy propyl methyl cellulose by solvent diffusion-evaporation method. The drug to polymer ratio used to prepare the different formulations was 1:7. The prepared floating microspheres were characterized for shape and surface morphology, size, percent drug loading, floating behavior, percentage yield and in vitro drug release. Formulation F1 showed good results with respect to the various evaluation parameters among various batches (F1-F8). The particle size increased with increase in polymer concentration. The drug entrapment efficiency was increased with increase in concentration of polymers. Buoyancy and the in vitro drug release decreased with respect to increase in concentration of polymers. In-vitro release and release kinetics data was subjected to different dissolution models. It was concluded that developed floating microspheres of DEX offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.

Keywords: Dexrabeprazole sodium, Floating drug delivery system, Microspheres, Solvent diffusion-evaporation method
The Analysis of Ischemic Stroke and Hemorrhagic Stroke based on Sugar Level
Authors: Simarmata Vidi Posdo A. , Suryanegara Wiradi
Published: November 2022

Stroke is the second leading cause of death worldwide, and stroke is more severe in patients with hemorrhagic stroke than ischemic stroke. Nearly 2 out of 3 patients with acute stroke have a high blood glucose level as a physiological response to an acute disease. Poor clinical outputs are often found in acute stroke patients with hyperglycemia. This study aims to determine the differences in blood glucose levels in ischemic stroke and hemorrhagic stroke patients in UKI General Hospital. It is descriptive observational research with the cross-sectional method. The sample is 132 patients, using total sampling with specified inclusion and exclusion criteria. The data used is secondary data. Data processing was performed using SPSS. The study revealed that from 108 ischemic stroke patients, 79 patients (73,1%) showed an increase in blood glucose level, and out of 24 hemorrhagic stroke patients, all the patients showed an increase in blood glucose level. The mean value of blood glucose level during ischemic stroke is 129,83mg/dL and in hemorrhagic stroke is 151,12mg/dL. The conclusion of this study, there is a significant difference (= 0,001) in blood glucose level, and the mean value of blood glucose level in hemorrhagic stroke is higher than in ischemic stroke.

Keywords: Random Blood Glucose, Ischemic stroke, hemorrhagic stroke, UKI General Hospital
Formulation and Evaluation of Orodispersible Tablets Containing Co-Crystals of Modafinil
Authors: Kumar Rajeev , Sheela M.A. , Sachdeva Monika
Published: November 2022

Background: Modafinil is a CNS stimulant used to treat Narcolepsy, sleepiness and other disorders related to sleep. It is a BCS class II drug having poor aqueous solubility.

Objective: This study was aimed to formulate and evaluate orodispersible tablets of containing co-crystals of Modafinil for the improvisation of critical attributes of the product such as dissolution rates, solubility and oral bioavailability.

Methods: Co-crystals were prepared by dry grinding method using Sodium acetate, Nicotinic acid, Benzoic acid, Urea and Succinic acetate as co-formers. Tablets were compressed by using direct compression method using SSG, Crospovidone, and Croscarmellose sodium as super disintegrants in different concentration.

Results: Pre-formulation studies were performed and evaluation of prepared co-crystals revealed that Co-crystals formulated with sodium acetate showed best results. The manufactured orodispersible tablets were evaluated for different parameters including weight variation, hardness, thickness, friability, drug content, In-vitro disintegration and In-vitro dissolution studies. Formulation F2 shows significant change in dissolution rate and also helped to increase the solubility of poorly water soluble drugs and both of them i.e. solubility and percentage of drug release are the key factors to exhibit the efficiency of the drug. Formulation of co-crystal with sodium acetate in 1:1 ratio showed highest drug content (97.97%), while Benzoic acid in ratio 1:2 showed least drug content (56.48%).

Conclusion: According to the result obtained, an orodispersible tablet containing co-crystals of modafinil enhances the dissolution rate, solubility and hence increases the therapeutic efficacy and could be considered convenient oral delivery systems to enhance the drug bioavailability.

Keywords: Co-crystal, Oro-dispersible, Sodium acetate, Narcolepsy, Sleepiness
Analysis of the Physico-Chemical Conformity of Antibiotics: Case of Amoxicillin 500 mg Capsule at the National Health Laboratory Distributed in Health Structures in Mali
Authors: CISSE Mody , DEMBELE Ousmane , TRAORE Nah , COULIBALY Seydou Moussa , CISSE B. Moussa , TRAORE Niélé Ousmane , DEMBELE Niaboula , BADIAGA Mamadou , TRAORÉ Boubacar , TRAORE Rokia , SANGARE Modibo , SOMBORO A. Aimé , KOUMARE Y. Benoît
Published: November 2022

Introduction: Amoxicillin belongs to the family of β-lactams and is one of the mostly used in hospitals for the management of bacterial infections especially in Mali. It has a broad spectrum of activity from the group of aminopenicillins or aminobenzylpenicillins (group A penicillins). Microbiological and physico-chemical control has evolved with the development of biotechnology. All bacterial species or germs are affected by the phenomenon of resistance to antibacterials, which often poses real therapeutic problems. Based on previous studies in Mali, amoxicillin is still recommended in pharmacies and university hospitals to treat bacterial infections. It sometimes happens that patients are not satisfied with this amoxicillin-based prescription in our teaching hospitals. The objective of this study was to control the physico-chemical quality of amoxicillin 500 mg in capsule form.

Methodology: This is a physico-chemical study of amoxicillin capsules dosed at 500 mg received at the National Health Laboratory in Bamako. We analyzed 10 batches of five (5) boxes (10 platelets/box) of amoxicillin. We used either HPLC, or TLC or Dissolu-test to control the quality of amoxicillin capsules for the presence of the active principle and to ensure fake amoxicillin capsules were not distributed. We used as reference, the standards contained in the pharmacopoeias in use.

Results: The results of the physicochemical tests revealed that the samples analyzed complied with the standards of the Pharmacopoeias in use: The weight of our capsules was between 0.5g and 0.6g. All the tested samples were compliant with a disintegration time of 15 minutes at 37°C ±2°C. The peaks of standard amoxicillin and that of the tested samples appeared at substantially equal retention times, i.e. at 3.249 min and 3.248 min. respectively.

Conclusion: Our work aimed to assess the quality of antibiotics used in Mali with the analytical means available at the LNS. All the batches of amoxicillin analyzed have not presented any cases of non-compliance so they can be distributed in health structures. This type of study should be extended to the other pharmaceutical forms of amoxicillin in the form of powders to be reconstituted dispensed in health centers in Mali.
Antimicrobial and Antioxidant Activities of Secondary Metabolites of an Endophytic fungus of Azadirachta indica
Authors: Okonkwo-Uzor Nkechi J. , Obi Cynthia , Enwelum Adaobi , Okezie Ugochukwu M. , Eze Peter M. , Okoye Festus B. C. , Esimone Charles O.
Published: November 2022

Background: Recent upsurge in the mortality rate and long hospital stays as a result of antimicrobial resistance caused by multi-drug resistant bacteria is a huge burden to public health sector. Intensive search for more effective and newer agents to deal with these problems. Endophytes are a novel source of potentially useful medicinal compounds. Aim: The study aimed at evaluating the antimicrobial and antioxidant activities of an endophytic fungus isolated from Azadirachta indica against multi drug resistant bacteria species. Method: Endophytic fungus was isolated from fresh leaves of Azadirachta indica. The fungus was fermented in rice medium, and the secondary metabolites were extracted. The antimicrobial activity of the extract against laboratory strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumonia and Bacillus subtilis, Candida albicans, Aspergillus niger) was determined. The fungal extract was also evaluated for antioxidant activity using the DPPH assay method. Using GC-FID analysis, some constituents of the fungal extracted were identified. Result: At 1 and 0.5 mg/mL, the fungal extract demonstrated antibacterial activity against Klebsiella pneumoniae but no activity against the other test microbes. However, the fungal extract of A. indica showed excellent antioxidant activity due to possession of bioactive secondary metabolites. Conclusion: The result of GC-FID showed the presence of Rutin, Lunamarin, Anthocyanin, Catechin, Naringenin, Flavan 3 ol, Sapogernin, Tannin, Spartein, Naringin, Flavonones, Steroids, Kaemferol, Cyanogenic glycoside, Phytate, Epicatechin, Reseveratol, Cardic glycoside and Epihedrine at different concentrations. This study reveals the dynamic potentials of the endophytic fungus of A. indica as the bedrock of naturally occurring bioactive agent. 

Keywords: Azadirachta indica, endophytes, GC-FID, secondary metabolites, medicinal plants, phytochemicals.
Review Article on Pharmaceutical Inventory Models
Authors: Dubey Mahima , Vishwakarma Harshna , Nisha Parveen
Published: November 2022

The inventory management system plays a vital role in a pharmaceutical industry. For every business, managing an inventory is important whether it is small or big, domestic or international business. In a pharmaceutical company, the raw materials have an expiry date associated with them so it becomes important to set a minimal safety stock for such items. The companies mostly try out keeping a minimum stock of products which will help in tracking our business easily. In this article, we present an overall review of the Pharmaceutical Inventory literature since the early 1968 and the models available in the relevant literature have been suitably classified. The motivations and extensions of various models in each subclass have been discussed in detail.

Keywords: Inventory, Perishable items, Pharmaceutical inventory, RFID technology, Drug inventory
Case report on the interaction between furosemide and digoxin that caused digoxin toxicity
Authors: Patel Riya , Patel Prancy , Patel Nisarg , Gangwani Jatin , Patel Dhaval
Published: November 2022

Toxicity from digitalis is a typical clinical issue. In this case, the interaction of digoxin and furosemide is becoming more widely recognised as a major cause of digitalis toxicity. We present an abnormal ECG that demonstrates digoxin-induced cardiotoxicity. We report a case of a Digoxin toxicity in a 79-year-old male patient admitted with complains of nausea, increase frequency of micturition, decrease appetite, increase nocturia, shortness of breathing. The patient is taking furosemide and digoxin as past medication for Heart block and Chronic kidney disease treatment. In patient, Serum digoxin level is high due to hypokalemia because of digoxin and furosemide drug interaction. The Electrocardiogram interpretation shows sinus bradycardia, ST segment depression, and T wave inversion which mainly due to digoxin toxicity. So for the management digoxin is omitted from the current treatment. The patient needs to be constantly monitored since digitalis poisoning is deadly. A digoxin-binding antibody is the only treatment for digoxin overdose that can reverse its effects by its antidote but it’s not available. So, the most successful course of treatment is symptomatic or efficient methods of extracorporeal drug removal.

Keywords: Digoxin toxicity, furosemide, hypokalemia, cardiotoxicity, complete heart block, ST segment depression.
The complex pathophysiology of urolithiasis (kidney stones) and the effect of combinational drugs
Authors: Malhotra Meenakshi , Tandon Pooja , Wadhwa Kritika , Melkani Indu , Singh Ajeet Pal , Singh Amar Pal
Published: November 2022

Body organs are very crucial when it comes to homeostatically maintaining them. If any changes occur in their function, it may lead to the development of diseases in the body. The kidney is one of the functionalised organs that is connected with the ureter and urinary bladder, which is basically the lower part of the body. The kidney priorly controls the volume of various body fluids, fluid osmolality, acid-base balance, various electrolyte concentrations, and the removal of toxins. Any dis-balance in the function of the kidney can generate a disease like renal calculi (kidney stone), chronic kidney disease (CKD), polycystic kidney disease (PKD), urinary tract infections (UTI), etc. Kidney stones (KS) are prevalent worldwide, affecting 15% of individuals. A stone arranged into various sizes may be micro, macro, and nano or found as mono or polycrystalline forms. The names of the two most common kidney stones, calcium and non-calcium stones (Uric acid stones, struvite stones, cysteine stones, and drug-induced KS), are determined primarily by their composition. Calcium stones are commonly found in individuals, approximately 80% of KS. This review provided recent details on kidney stone symptoms, etiology, psychophysiology, and management perspective.

Keywords: Kidney disease, calcium stone, renal calculi, chronic kidney disease, Polycystic kidney disease.
Statin Therapy for The Primary Prevention of Cardiovascular Disease: Pros
Authors: Laksono Sidhi , Umami Fadhilla , Nurusshofa Zahra , Mustifah Etty Farida
Published: November 2022

Cardiovascular disease (CVD) is the leading cause of death worldwide. Dyslipidemia is one of the causes of cardiovascular disease with a contributor to plaque formation.Statins are a class of drugs that lower cholesterol levels by inhibiting the enzyme HMG-CoA reductase. The purpose of statin therapy is to reduce the risk of cardiovascular and associated morbidity and mortality. Statins have a significant impact on reducing atherosclerosis cardiovascular disease. However, primary prevention of ASCVD using statins is debated although statins have several advantages. This review describes the pros of using statins as primary prevention of cardiovascular disease .A comprehensive electronic search was conducted using PubMed, Google Scholar, and ScienceDirect. The search was limited to English-language publications from 2002 to 2021. Hand-searching of relevant journals and reference lists was also performed. It is found that statins can lower cholesterol levels to prevent the formation of atherosclerosis, which then progresses to cardiovascular disease. Recognizing the presence of coronary artery calcium with imaging strategies can guide the initiation of therapy in young adults. Statins have pleiotropic effects to prevent cardiovascular, cost effective, safe, effective, and well tolerated. On the other hand, statins are still debated in older adults. Statins are a primary preventive consideration to reduce morbidity and mortality due to cardiovascular disease.

Keywords: statin, atherosclerosis, primary prevention, and cardiovascular disease
The Pharmacological and Therapeutic Activities of Canavalia gladiata (Jacq.) DC.
Authors: Pal Mrinalini , Pandey Vaibhav Sharan , Dhawal Ajay , Upadhyay Prachi , Upadhyay Prachi , Vartika , , Sharma Ratanajay , Singh Brahmanand , Das Ishwar , Pandey Vashist Narayan
Published: November 2022

Canavalia gladiata is a perennial ethnomedicinal climber food plant found throughout the World. It shows many therapeutic properties which can be utilized for the treatment against many human diseases. In this review, we surveyed the recent findings on the pharmacological and therapeutic properties of Canavalia gladiata. The objective of this is to provide detail analysis on active compounds present in this species and to provide information regarding its pharmacological activities on human diseases and safety. Its bioactive compounds possess outstanding pharmacological properties like hemagglutianting activity, HIV-I inhibition, antimicrobial, antiproliferative, hepatoprotective, ROS- inhibitor, anti-cancer and anti-diabetic properties has been studied. The chemical constituents, pharmacological activities and therapeutic studies of C. gladiata showed a promising medicinal plant with various chemical compounds and numerous pharmacological activities.

Keywords: Pharmacological activities, Therapeutics, Bioactive compounds, Canavalia gladiata.
Manejo de eventos adversos en unidades de Neonatología en América: una revisión de la literatura
Authors: Jara-Rosales Sergio , Calderón-Tampe Loreto , Ávila-Flores Camila , Calderón-Bermúdez Francisca , Rodríguez-Fuentes Gabriela , Romero-Sepúlveda Constanza , Zavala-Castro Victoria
Published: November 2022

Introducción: Los eventos adversos (EA) son un acontecimiento imprevisto no intencional que causa daño a los pacientes. En neonatología, existe mayor prevalencia de EA debido a la fragilidad de los pacientes.

Objetivo: Analizar la literatura científica publicada entre los años 2011-2021 sobre el manejo de los EA en servicios de Neonatología en América.

Metodología: Revisión bibliográfica. Bases de datos: PUBMED, EBSCO, Google Scholar y Scielo. Descriptores DeCS: “Administración de la Seguridad”, “Neonatología”, “Prevención y Control”, “Errores Médicos”, “Seguridad del Paciente”, “Unidad de Cuidados Intensivos Neonatales” en español, inglés y portugués. Operadores booleanos: “AND” y “OR”. Lectura crítica considerando criterios de inclusión: artículos sobre tipos, control y manejo de EA en neonatología; países de América.

Resultados: Se seleccionaron 18 artículos: 14 de EE. UU y 4 de Brasil. Los EA más frecuentes son: mal almacenamiento, mala técnica de administración, dilución errónea y error en la prescripción de medicamentos. Las causas más comunes de EA son: carga laboral y estrés. Estrategias de prevención: buena higiene y asepsia, uso correcto de EPP, adecuada dotación de personal, tecnología de códigos de barra para control de medicamentos, liderazgo, trabajo en equipo, comunicación, capacitación y educación al personal de salud. Una correcta notificación permite detectar y monitorear los EA, lo cual perfecciona su manejo.

Discusión/Conclusión: Con sistemas de notificación y protocolos adecuados el manejo de los EA es más eficaz, disminuyendo la probabilidad de daño a los recién nacidos.
Carta al Editor | Noviembre 2022
Authors: Vargas-Stevenson Ingrid
Published: November 2022

Matrona Ingrid Vargas StevensonDirectora Revista Matronería ActualNoviembre de 2022

Estimada Editora Jefa:

La Revista Matronería Actual de la Escuela de Obstetricia y Puericultura de la Universidad de Valparaíso, nace como un espacio reflexivo para la publicación de artículos de diversos saberes, como ciencias humanas, ciencias básicas, ciencias de la salud como obstetricia, neonatología, salud pública y comunitaria, educación, entre otras, que pretenda aportar al desarrollo y quehacer de la matronería.

En ese sentido, y con el fin fomentar la investigación en la diciplina de la matronería, nuestra revista organizó en forma conjunta con la Escuela de Obstetricia y Puericultura de la Universidad Austral y el Instituto de Salud Sexual y Reproductiva de la Universidad Austral de Chile, el I Congreso virtual Iberoamericano de Investigación en Matronería, realizado el 21 y 22 de abril del año 2022.

El Congreso se creó con la intención de potenciar la investigación, tanto en estudiantes y a nivel de docentes de las carreras de Obstetricia y Puericultura de nuestro país, como uno de los ejes de la formación en las diferentes áreas de la disciplina. A la vez, se planteó como espacio de encuentro universitario en torno a los avances en investigación, con miras a la conformación de redes de estudio nacionales e internacionales.

En este número especial, se publican los resúmenes de los trabajos presentados en esta instancia, tanto en exposición oral como en formato e-póster, los cuales fueron desarrollados en distintas áreas de la matronería.

Invito a los (as) lectores (as) de este número a adentrarse en los artículos publicados por docentes y estudiantes que nos acercan a los avances en matronería de los últimos años
CORRELATION ANALYSIS OF PARENTAL SUPPORT AND CONFIDENCE IN ADOLESCENTS WITH DEFENSE YOUTH
Authors: Andriani Ayu , Lengkong Felix
Published: November 2022

Self-confidence is an important factor for adolescents who are deaf. Self-confidence is a form of feeling confident about the ability that an individual has to be able to achieve life goals. To get confidence, parental support is needed. Parental support causes teenagers to feel comfortable, feel loved and cared for. This study aims to determine the relationship between parental support and self-confidence of adolescents with hearing impairment at SLB-B Pangudi Luhur. The research method is quantitative. Data obtained through questionnaires that have been tested first. The number of samples in this study were 63 subjects, who were Pangudi Luhur SMPLB and SMALB students aged 13-18 years. Based on the results of data analysis, it is known that the correlation coefficient between parental support and self-confidence is 0.609 with a significance level of 0.000. This means that there is a relationship between parental support and the confidence of adolescents with hearing impairment at the SLB-B Pangudi Luhur. This means that the higher parental support, the higher the confidence of adolescents with hearing impairment in the SLB-B Pangudi Luhur.
THE IMPACT OF TRAUMA FOR RELIGIOUS IDENTITY AFTER CIVIL CONFLICT: STUDY AT BOARDING SCHOOL BABUL ALA NURILLAH BEUTONG ATEUH NAGAN RAYA ACEH INDONESIA
Authors: Jannah Miftahul , Kamsani Siti Rozaina , Ariffin Nurhazlina Mohd
Published: November 2022

The impact of prolonged civil conflict in Aceh has caused lost family and mental disorder to the local community. One of the tragedy occurred during conflict in Aceh was the killing tragedy in Boarding School Babul 'Ala Nurillah, Blang Meurandeh village Beutong Blang Galang Nagan Raya Aceh Province Indonesia on July 23, 1999 and killed more than 50 man when they are in Boarding School ( Dayah) and learn Islamic knowledge.The peace agreement after conflict between Free Aceh Movement and Indonesia Goverment has 16 years ago since August 18, 2005. They are saw their husband killed by army, andmany women became widows and became poor life. The purpose of this study is to know how the traumatic post conflict and misdevelopment about the religious identity. The Method of this study used quantitative and qualitative method, used scale TSI (Trauma Syndrome Inventory) for trauma by Briere with 100 items and MRPI (Muslim Religious-Personality Inventory)  for scale religious identity. MRPI has 47 item. The sample in this research 25 Woman and 5 man who directly saw the extrajudicial killing, this sample technique used random assigned sampling.The result showed that the victims there are have traumatized is: high trauma 3, low trauma 3, and middle trauma 24 person . The result of this study is that there is a relationship between trauma and religious identity is low  r = -0,312. The correlation beetween trauma and Islamic worldview and spiritual is r = 0.312 (low), trauma with ritual r= 0.543 (medium), trauma with muamalat = 0.157 (very low). This meaning that although the victims feel traumatized but their ritual (hablun min Allah) still good in medium correlation, but the correlation between trauma and Islamic worldview and spiritual is low, and correlation between trauma and mu’amalat (hablun min an-naas) is very low, as well as in religious personality which is divided into Islamic worldview and spiritual, ritual (hablun minallah) and muamalat (hablun min an-naas). After twenty years ago they can to growth with their self and they want to forgotten the tragedy July 23 1999, and want to live in peace. And now they have the commitment to explore and learn Islamic knowledge again after twenty years ago they life without learning the Islamic knowledge in boarding school.
EUDAIMONIA IN A CUP OF COFFEE: WELL-BEING OF ACEHNESE BARISTA
Authors: Akhsani Yuri , Abidin Zainal
Published: November 2022

The development of coffee shops in Banda Aceh over the past few years has been accompanied by increasing interest of young people in becoming a barista. This interest is not only caused by the availability of the job, but also the desire to fulfill eudaimonic goals. Based on the concept of eudaimonic well-being, quality of life comes from developing one’s potential and the applications in personally expressive goals, which is shown through the act of pursuing the eudaimonic goals. The phenomenon in Banda Aceh shows that this pursuit comes by becoming a barista. Thus, this study aims to explore the experience of baristas through the framework of eudaimonic well-being theory. This study uses qualitative approach to gain understanding on eudaimonic well-being of baristas in Banda Aceh. The results of this study indicate the pursuit of eudaimonic well-being in all participants, albeit with individually unique methods and motivations.
The Church of Drunkards: Tavern in Goliardic Poetry
Authors:   National Research University Higher School of Economics, Dolgorukova Natalia M. , Babenko Kseniia V. ,   National Research University Higher School of Economics
Published: November 2022

Goliardic poetry is an extraordinary phenomenon of medieval literature. These texts were treated in many different ways, i. e. as a historical source of social and class relationships of medieval society, or as a part of the church, university, or marginal culture history. However, few scholars are inclined to perceive them as literature. This work is focused on the section of drinking and gambling songs from Carmina Burana, most famous goliardic manuscript. It traces a common trend in the descriptions of the tavern and its inhabitants to outline some specific system applicable for those descriptions. Goliardic songs are analyzed not only in connection with each other, but also in the context of official church literature and Holy Scripture. The study revealed that the tavern in goliardic poems is presented both as a parodic analogue of the Church and as its opposite: almost every phenomenon of church life in goliardic texts is rethought and replaced by a parody doublet (prayers — toasts, Bacchus — Christ, liturgical wine — profane wine). The results of this work is applicable to better understanding of the medieval people’s mentality and reconstruction of daily life in Western Europe of the Middle Ages.
Calvary
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Surat Irina Z.
Published: November 2022

The article is dedicated to the subject of the crucifixion in Russian lyric poetry of 19th–21st centuries. It studies five poems that present different images of Calvary. Analyzing A.S. Pushkin’s “Worldly power” we discover a lexical connection of the poem to prayers and liturgical texts. The poem “When rowan leaves are dank and rusting…” by A.A. Blok requires consideration from two angles: among his other Christological poems and in the light of a general among symbologists tendency of eroticizing Christian images. We demonstrate that the subject of co-crucifixion is natural for Blok, that it was slowly emerging in his lyric poetry of the 1900s. The article analyzes O.E. Mandelstam’s poem “The implacable words…” in the context of his lyric poetry of the 1910s, as well as in comparison to the later variation of the image (“Like chiaroscuro’s martyr Rembrandt…”). The research reveals “maternal projection” of the subject of Calvary on the example of the poem “Mother” by V.V. Nabokov, passages from A.A. Akhmatova’s poem "Requiem” and I.A. Brodsky's poem “Still-life.” El.A Shvarts’s poem “Rembrandt’s etching — Christ and the thieves” represents ekphrastic versions of the biblical story.
Increasing winter temperatures explain declines in body size of boreal birds
Authors: Bosco Laura , Otterbeck Andreas , Lindén Andreas , Fransson Thord , Piha Markus , Lehikoinen Aleksi
Published: November 2022

Body size of individuals is typically increasing towards colder and
higher latitudes, as larger body size is known to be a thermoregulatory
adaptation to colder circumstances. Here we explored the
spatio–temporal changes in wing length and body weight of 24 wintering
bird species in Northern Europe and how these relate to annual changes
in winter temperature. We show that across all species, body size has
decreased since the 1970s, with a negative relationship between wing
length and temperature anomalies of previous winters, suggesting carry
over effects likely linked with body size–related survival or
dispersal. Body weight was negatively related with the temperature
anomaly of the same winter, indicating more immediate effects related to
reduced fat reserves during mild winters. Our results highlight
climate–driven decrease in body size across several species and its’
association with annual variation in winter temperature in the high
latitudes.
Key Factors to Increasing Free Cash Flow for Manufacturers Utilizing Lean Production: An AHP-DEMATEL Approach
Authors: Kang Cathay Kuo-Tai , Lin Chieh-Yu , Ho Yi-Hui
Published: November 2022

This paper aims to apply AHP and DEMATEL to analyze the key factors and interrelationships of lean production to increase free cash flow for manufacturers. The AHP hierarchy was determined through literature and interviews with leading management experts. The assessment criteria were categorized into five major criteria and 15 sub-criteria, including production, sales, human resources, R&D, and finance. According to the AHP results, the first eight key factors were identified as the key factors to increasing cash flow for manufacturers who utilized lean production. DEMATEL was used to identify the interactions among the eight key factors and further identify the four more important ones. The four key factors are strategic planning, strategic deployment, leadership, and goal orientation. This paper proposes management implications and improvement suggestions for the four key factors and their interactions.
Effect of Nsukka Red Palm Oil on Haematological Parameters of Paracetamol Treated Albino Wister Rats
Authors: MU Obeta
Published: November 2022

Nsukka palm oil (red palm oil -RPO) has been described as one of the best RPO in Nigeria. It has been the most expensive RPO among others. RPO has an antioxidant activity. Paracetamol equally has been one of the most commonly used analgesic and antipyretic drug that has been highly abused because of self-medication among Nigerians. The study was aimed at discovering the RPO effect on the toxicity of paracetamol in haematological parameters. Twenty albino Wister rats, divided into four groups of five rats each were used in this study, the first group was the control group while the rest group were the experimental groups, group 3 and 4 were pretreated with 1ml and 2ml red palm oil respectively, however on the fifth day 3g/ kg body weight of oral paracetamol was given to group 2, 3 and 4. Haematological parameters - red blood cell count, white blood cell count and white cells differential count were also assayed using routine methods. The group with 1ml RPO showed significance (5.10±0.04) P<0.05 of RBC when compared with control (4.66.10±0.05) and paracetamol (4.88±0.05) groups. The group with 2ml RPO (9.02±0.05), 1ml RPO (8.98±0.05) showed significance at P<0.05 when compared with groups Control (6.06±0.05) and Paracetamol (7.40±0.23) in WBC counts. The group with 1ml RPO (65.02±1.05) showed significance at P<0.05 in neutrophil when compared with control (63.00±0.63) and Paracetamol (62.90±0.84) and 1ml RPO (20.60±0.81) showed significance at P<0.05 in lymphocyte count when compared with control (22.20±0.80) and Paracetamol (23.80±0.37). RPO has effects on haematological parameters especially on albino rats treated with paracetamol and can be volume dependent based on the weights. Nsukka red palm oil could be recommended in paracetamol toxicity in animals and man.
MHD stagnation point flow over a stretching or shrinking sheet in a porous medium with velocity slip
Authors:   Department of Mathematics and Statistics, Faculty of Science, University of Putra Malaysia, Japili N. , Rosali H. ,   Department of Mathematics and Statistics, Faculty of Science, University of Putra Malaysia, Bachok N. ,   Department of Mathematics and Statistics, Faculty of Science, University of Putra Malaysia
Published: November 2022

Magnetohydrodynamics (MHD) stagnation point flow in a porous medium with velocity slip is investigated in this study. The governing system of partial differential equations is transformed into a set of non-linear ordinary differential equations by using the similarity transformation. Subsequently, the transformed equations are numerically solved by using the shooting method in MAPLE software. The skin friction coefficient and the local Nusselt number are obtained and presented graphically. The effects of the governing parameters including the velocity slip, magnetic and permeability parameters, are examined. It is found that both the skin friction coefficient and the local Nusselt number increase as magnetic and permeability parameters increase.
New development of homotopy analysis method for non-linear integro-differential equations with initial value problems
Authors:   Faculty of Ocean Engineering Technology and Informatics, University Malaysia Terengganu, Eshkuvatov Z. K. ,   DSc Doctorate, Faculty of Applied Mathematics and Intellectual Technologies, National University of Uzbekistan
Published: November 2022

Homotopy analysis method (HAM) was proposed by Liao in 1992 in his PhD thesis for non-linear problems and was applied in many different problems of mathematical physics and engineering. In this note, a new development of homotopy analysis method (ND-HAM) is demonstrated for non-linear integro-differential equation (NIDEs) with initial conditions. Practical investigations revealed that ND-HAM leads an easy way how to find initial guess and it approaches the exact solution faster than the standard HAM, modified HAM (MHAM), new modified of HAM (mHAM) and more general method of HAM (q-HAM). Uniqueness solution of the problem and convergence of ND-HAM are proved in the Banach space. Finally, two examples are illustrated to show the accuracy and validity of the proposed method. Five methods are compared in each example.
Traumatic Thrombosis of the Intra-Petrous and Cavernous Segment of the Internal Carotid Revealed by Otological Symptoms: A Case Report
Authors: Rochd Sara , Benhoummad Othmane , Rizkou Fatimezzahra , Lakhdar Youssef , Rochdi Youssef , Raji Abdelaziz
Published: November 2022

Introduction: Thrombosis of the internal carotid following a non-penetrating blunt trauma is rare and unusual, implicating mostly intimal and medial vessel wall damage. With the lack of proper clinical presentation, it’s often diagnosed by arteriography while searching for expansive cerebral hemorrhagic complications. Case report: Hence, the report of this rare case of a post blunt trauma thrombosis of the intra-petrous and cavernous segment of the internal carotid in a 26-years-old male patient was revealed 1 year later by otological symptoms. CT scan, MRI, and angiography confirmed the diagnosis. Conclusion: Management of this serious injury is controversial, to say the least among authors involving both medical and surgical treatment.
Neuro-Legal Sciences from a Neo Contemporary and Futuristic Perspective
Authors: Adán Ríos Alfredo
Published: November 2022

This article is conducted according to a documentary theoretical investigation under a proposal that claims to have foundations of realistic orthodox scientific rigor because it is not a science fiction novel rather it is a realistic framework of what happens in the neo-contemporary progress to axioms Futurists that can be seen as retro-futuristic phenomena in terms of the applicability of the sciences of “complexity” as they call it today for the progress of neuro-legal sciences at an international and national level in any entity. This in order to see the scope before a critical point in the face of its infinitesimal axioms that collaborative fields of high scientific specialty can provide, of which are the experimental cognitive theoretical neurophysics in auxiliary support to the evolutionary and biophysically inspired computational cognitive neurosciences. Its primary scope is to recapitulate the greatest advances from a current perspective of the developments that the scientific community wants to achieve to support said theoretical application fields from which this documentary contribution can be based and a theoretical proposal of how these advances can reach their point evolution critic to his ultimate axiom of development.
PENGARUH PRODUK DOMESTIK REGIONAL BRUTO (PDRB) DAN INVESTASI TERHADAP PENYERAPAN TENAGA KERJA DI KOTA MEDAN
Authors: Magdalena Siska , Rozaini Noni
Published: November 2022

Economic development has an important goal, one of which is to pursue job growth, so that there are sufficient job opportunities to realize this goal. This study aims to examine the involvement of GRDP and investment in employment, especially in the city of Medan. This study uses a quantitative type and data acquisition comes from Time Series from 2001 to 2020. The secondary data used in this study comes from the Central Bureau of Statistics of North Sumatra which is used as a source of data in the study, using E-views9 and using regression analysis. multiple linear for data processing.The study obtained results where the GRDP variable had a positive and significant effect on employment in the city of Medan having a result of 0.000 in its significance level. While the significance value of investment to employment is 0.1856, this means that it is positive but not significant. As for the third variable, it has a significance value of 87.65 percent to the absorption of labor in the city of Medan.Keywords : GRDP, Investment, and Labor Absorption
PENGARUH INFLASI DAN UPAH MINIMUM KOTA (UMK) TERHADAP TINGKAT PENGANGGURAN TERBUKA DI KOTA PADANG SIDEMPUAN
Authors: Nabila Nabila , Rozaini Noni
Published: November 2022

This study aims to determine how the effect of inflation and the municipality minimum wage on the open unemployment rate in Padang Sidempuan City in 2006-2020. The type of research used in this study is quantitative research and uses secondary data with a time series type. The source of data in this study is the official website of the Badan Pusat Statistik (BPS). The analytical method used in this study is multiple linear regression analysis, which is processed using the E-views 10 program. The results of this study indicate that partially inflation has a positive and insignificant effect on the unemployment rate with a significance value of 0.8990. The municipality minimum wage  has a negative and significant effect on the open unemployment rate with a significance value of 0.0002. And simultaneously inflation and the municipality minimum wage have a significant effect on the open unemployment rate with a significance value of 0.000076 and the independent variables of inflation and the municipality minimum wage have an effect of 79.40% on the open unemployment rate in Padang Sidempuan City.