bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-equivalence tests in functional data by maximum deviation
Authors: Dette Holger , Kokot Kevin
Published: October 2020

We study the problem of testing equivalence of functional parameters, such as the mean or the variance function, in the two-sample functional data setting. In contrast to previous work where the functional problem is reduced to a multiple testing problem for the equivalence of scalar data by comparing the functions at each point, our approach is based on an estimate of a distance measuring the maximum deviation between the two functional parameters. Equivalence is claimed if the estimate for the maximum deviation does not exceed a given threshold. We propose a bootstrap procedure for obtaining quantiles of the distribution of the test statistic, and we prove consistency of the corresponding test in the large-sample scenario. As the methods proposed here avoid the use of the intersection-union principle, they are less conservative and more powerful than currently available approaches.
Development of the Neuro-Immune-Vascular Plexus in the Ventricular Zone of the Prenatal Rat Neocortex
Authors: Penna Elisa , Mangum Jon M , Shepherd Hunter , Martínez-Cerdeño Veronica , Noctor Stephen C
Published: October 2020

Microglial cells make extensive contacts with neural precursor cells (NPCs) and affiliate with vasculature in the developing cerebral cortex. But how vasculature contributes to cortical histogenesis is not yet fully understood. To better understand functional roles of developing vasculature in the embryonic rat cerebral cortex, we investigated the temporal and spatial relationships between vessels, microglia, and NPCs in the ventricular zone. Our results show that endothelial cells in developing cortical vessels extend numerous fine processes that directly contact mitotic NPCs and microglia; that these processes protrude from vessel walls and are distinct from tip cell processes; and that microglia, NPCs, and vessels are highly interconnected near the ventricle. These findings demonstrate the complex environment in which NPCs are embedded in cortical proliferative zones and suggest that developing vasculature represents a source of signaling with the potential to broadly influence cortical development. In summary, cortical histogenesis arises from the interplay among NPCs, microglia, and developing vasculature. Thus, factors that impinge on any single component have the potential to change the trajectory of cortical development and increase susceptibility for altered neurodevelopmental outcomes.
Chemogenetics Reveal an Anterior Cingulate–Thalamic Pathway for Attending to Task-Relevant Information
Authors: Bubb Emma J , Aggleton John P , O’Mara Shane M , Nelson Andrew J D
Published: October 2020

In a changing environment, organisms need to decide when to select items that resemble previously rewarded stimuli and when it is best to switch to other stimulus types. Here, we used chemogenetic techniques to provide causal evidence that activity in the rodent anterior cingulate cortex and its efferents to the anterior thalamic nuclei modulate the ability to attend to reliable predictors of important outcomes. Rats completed an attentional set-shifting paradigm that first measures the ability to master serial discriminations involving a constant stimulus dimension that reliably predicts reinforcement (intradimensional-shift), followed by the ability to shift attention to a previously irrelevant class of stimuli when reinforcement contingencies change (extradimensional-shift). Chemogenetic disruption of the anterior cingulate cortex (Experiment 1) as well as selective disruption of anterior cingulate efferents to the anterior thalamic nuclei (Experiment 2) impaired intradimensional learning but facilitated 2 sets of extradimensional-shifts. This pattern of results signals the loss of a corticothalamic system for cognitive control that preferentially processes stimuli resembling those previously associated with reward. Previous studies highlight a separate medial prefrontal system that promotes the converse pattern, that is, switching to hitherto inconsistent predictors of reward when contingencies change. Competition between these 2 systems regulates cognitive flexibility and choice.
Strategic Narratives in Global Trade Politics: American Hegemony, Free Trade, and the Hidden Hand of the State
Authors: Hopewell Kristen
Published: October 2020

The characterization of the United States as a liberal hegemon seeking to uphold free-market capitalism against the illiberal state capitalism of China and other emerging powers has become commonplace, along with the attendant notion that American economic openness has been exploited by the unfair trade practices of other states. Given their dominance in US political discourse and role in shaping contemporary policy—including fuelling Trump’s trade wars and aggressive unilateral trade actions against all of the United States’ major trading partners, his attacks on the World Trade Organization, and talk of a “new Cold War” between the United States and China—these claims merit far greater scrutiny. In this article, I challenge the stark dichotomy frequently drawn between American “free-market capitalism” and the “state capitalism” of its emerging challengers, arguing that this forms part of a strategic narrative deployed for political purposes, including legitimating the United States’ use of aggressive trade policy measures. An examination of the American hegemon’s actual trade and industrial policies complicates this characterization. Despite presenting itself as a promoter and defender of free trade, I show that the unifying logic of US trade policy has always been the promotion of American economic interests: the United States has engaged in considerable state intervention and trade protectionism, both to shield vulnerable industries and support others to achieve and maintain their global dominance.
Heart regeneration: beyond new muscle and vessels
Authors: Sayers Judy R , Riley Paul R
Published: October 2020

The most striking consequence of a heart attack is the loss of billions of heart muscle cells, alongside damage to the associated vasculature. The lost cardiovascular tissue is replaced by scar formation, which is non-functional and results in pathological remodelling of the heart and ultimately heart failure. It is, therefore, unsurprising that the heart regeneration field has centred efforts to generate new muscle and blood vessels through targeting cardiomyocyte proliferation and angiogenesis following injury. However, combined insights from embryological studies and regenerative models, alongside the adoption of -omics technology, highlight the extensive heterogeneity of cell types within the forming or re-forming heart and the significant crosstalk arising from non-muscle and non-vessel cells. In this review, we focus on the roles of fibroblasts, immune, conduction system, and nervous system cell populations during heart development and we consider the latest evidence supporting a function for these diverse lineages in contributing to regeneration following heart injury. We suggest that the emerging picture of neurologically, immunologically, and electrically coupled cell function calls for a wider-ranging combinatorial approach to heart regeneration.
Empirical formula for the quality factors of crack resonances and its application to the estimation of source properties of long-period seismic events at active volcanoes
Authors: Taguchi Kimiko , Kumagai Hiroyuki , Maeda Yuta , Torres Roberto
Published: October 2020

Long-period (LP) seismic events at active volcanoes are thought to be generated by oscillations of fluid-filled resonators. The resonator geometry and fluid properties of LP sources have been estimated by comparing observed frequencies and quality factors (Q) with those calculated by numerical simulations with a crack model. A method to estimate all the parameters of crack geometry and fluid properties using an analytical formula for crack resonance frequencies has recently been proposed, but this method requires long computational times to compare observed and simulated Q values, especially for LP events with large Q. To resolve this problem, we used numerical simulations to systematically investigate the empirical relation between Q and crack model parameters. We found that Q can be calculated with an empirical formula expressed by the crack width-to-length ratio and the ratio of P-wave velocity in the solid medium to sound speed in the fluid. We applied this formula to LP events at Kusatsu–Shirane volcano, Japan, between 1992 August and 1993 January and at Galeras volcano, Colombia, in 1993 January. Assuming misty gas as the fluid in the crack at Kusatsu–Shirane and dusty gas as the fluid at Galeras, the empirical formula provided more detailed estimates of the parameters than those obtained previously using the Q values estimated in numerical simulations. We then applied the empirical formula to LP events with large Q values observed at Galeras between 2006 December and 2007 January. When we assumed dusty gas as the fluid in the crack, we found decreasing trends in both crack volume and the gas-weight fraction of water vapour in the crack. We also found that the dust volume was proportionally related to the product of crack aperture and crack length or width. These trends and relations were similar to those in 1993 January, suggesting that the LP events at Galeras between 2006 and 2007 were triggered by the explosive fragmentation of intruded magma and the production of a dusty gas, as was previously inferred for the LP events in 1993 January. Welding of ash in the dusty gas and dense magma remaining in the conduit after fragmentation led to a decrease in the source crack size prior to the next LP event. These results demonstrate that our empirical formula for Q can be used to estimate the source properties of LP events with large Q values without requiring long computational times. Use of the formula may thus contribute to improved monitoring of fluid states and understanding of LP triggering processes beneath many volcanoes.
Geographical Indications: A Major Challenge for MERCOSUR
Authors: Blasetti Roxana
Published: October 2020

This article focuses on the intellectual property chapter of the EU-MERCOSUR Free Trade Agreement. It is not intended to provide an exhaustive analysis of all the intellectual property rights involved but to go deeply into a specific matter, geographical indications, which is undoubtedly a controversial concession in the chapter.

The entire free trade agreement negotiations took more than 20 years and ended in June 2019 with an ‘Agreement in principle’. From the very beginning it involved a red line for the MERCOSUR countries, namely the intellectual property chapter.

This article will show the complexity of including the private rights of prior users (generic names, plant varieties and trademarks) as a trade-off for agricultural market access in negotiations mainly focused on tariff reduction and trade rules.

In addition, the imbalance between the parties was deepened by the lack of regionally harmonized intellectual property standards within MERCOSUR.

In this regard, the main objective of this article is to identify the legal challenges derived from the overlap of national, regional and bi-regional rules that the Mercosur countries will face when implementing the geographical indication commitments, given the bloc’s legal and institutional structure. Unlike tariff reduction, the commitments derived from the negotiation of private rights are a crucial issue. Against this background, some proposals are outlined to address how to determine a medium- and long-term strategy based on the needs of local producers to add value to their productions.
Comparison of early postoperative cytokine changes in patients undergoing intubated and non-intubated thoracic surgery: a randomized controlled trial
Authors: Jeon Joonpyo , Sung Sookwhan , Moon Youngkyu , Koo Jungmin , Hyun Kwanyong , Han Kyungdo , Hwang Wonjung
Published: October 2020

OBJECTIVES

The inflammatory response after surgery is associated with patient prognosis. Patients who undergo thoracic surgery exhibit a profound systemic inflammatory response due to the surgical procedures used and application of one-lung ventilation. The aim of this study was to compare perioperative inflammatory changes in patients after intubated and non-intubated thoracic surgery for primary lung cancer resection.

METHODS

This prospective randomized controlled study included forty patients who underwent surgical resection for stage I non-small-cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at 1 and 24 h after surgery. Levels of the pro-inflammatory cytokine and anti-inflammatory cytokines were measured using quantitative sandwich enzyme immunoassay kits.

RESULTS

The basal values of cytokines were comparable between 2 groups. Within each group, the postoperative levels of interleukin (IL)-1, IL-6 and tumour necrosis factor-α increased, while those of IL-4 and IL-10 did not change significantly. The levels of IL-6 and tumour necrosis factor-α were significantly lower in group NI at 1 and 24 h postoperatively. Other cytokines did not differ in both groups during postoperative period. The IL-6/IL-10 ratio at 1 h after surgery was lower in non-intubated patients than in intubated patients, but there was no difference at 24 h after surgery

CONCLUSIONS

Non-intubated thoracic surgery may attenuate the early inflammatory cytokine changes following major resection for primary lung cancer compared with intubated conventional surgery.

Clinical trial registration

ClinicalTrials.gov registry number NCT04007354
Can public access to documents support the transparency of automated decision-making? The European Union law perspective
Authors: Mazur Joanna
Published: October 2020

Due to the concerns which are raised regarding the impact of automated decision-making (ADM) on transparency and their potential discriminatory character, it is worth examining the possibility of applying legal measures which could serve to increase transparency of ADM systems. The article explores the possibility to consider algorithms used in ADM systems as documents subjected to the right to access documents in European Union (EU) law. It is focused on contrasting and comparing the approach based on the right to access public documents developed by the Court of Justice of European Union (CJEU) with the approach to the right to access public information as interpreted by the European Court of Human Rights (ECtHR). The analysis shows discrepancies in the perspectives presented by these Courts which result in a limited scope of the right to access public documents in EU law. Pointing out these differences may provide a motivation to clarify the meaning of the right to access information in EU law, the CJEU’s approach remaining as for now incoherent. The article presents the arguments for and ways of bringing together the approaches of the CJEU and the ECtHR in the light of a decreasing level of transparency resulting from the use of ADM in the public sector. It shows that in order to ensure compliance with EU law, it is necessary to rethink the role which the right to access information plays in the human rights catalogue.
Design and development of Referrals Automation, a SMART on FHIR solution to improve patient access to specialty care
Authors: Odisho Anobel Y , Lui Hansen , Yerramsetty Ramakrishna , Bautista Felicisimo , Gleason Nathaniel , Martin Edwin , Young Jerry J , Blum Michael , Neinstein Aaron B
Published: October 2020

Background

Referring patients to specialty care is an inefficient and error-prone process. Gaps in the referral process lead to delays in patients’ access to care, negative patient experience, worse health outcomes, and increased operational costs. While implementation of standards-based electronic referral options can alleviate some of these inefficiencies, many referrals to tertiary and quaternary care centers continue to be sent via fax.

Objective

We describe the design process and architecture for a software application that has been developed and deployed to optimize the referrals intake process by automating the processing and digitization of incoming specialty referral faxes, extracting key data elements and integrating them into the electronic health record (EHR), and organizing referrals.

Methods

A human-centered design approach was used to identify and describe the inefficiencies in the external referral process at our large, urban tertiary care center. Referrals Automation, an application to convert referral faxes to digital referrals in the EHR, was conceptualized based on key stakeholder interviews and time and motion studies. This application was designed using Substitutable Medical Applications and Reusable Technologies (SMART) and Fast Healthcare Interoperability Resource (FHIR) platforms to allow for adaptability into other healthcare organizations.

Results

Referrals Automation software was developed as a healthcare information technology solution to streamline the fax to referral process. The application was implemented into several specialty clinics. Metrics were built-in to the applications to evaluate and guide the further iteration of these features.

Conclusions

Referrals Automation will enhance the referrals process by further streamlining and organizing the patient referral process.
A geometric deep learning approach for checking element-to-entity mappings in infrastructure building information models
Authors: Koo Bonsang , Jung Raekyu , Yu Youngsu , Kim Inhan
Published: October 2020

Data interoperability between domain-specific applications is a key prerequisite for building information modeling (BIM) to solidify its position as a central medium for collaboration and information sharing in the construction industry. The Industry Foundation Classes (IFC) provides an open and neutral data format to standardize data exchanges in BIM, but is often exposed to data loss and misclassifications. Concretely, errors in mappings between BIM elements and IFC entities may occur due to manual omissions or the lack of awareness of the IFC schema itself, which is broadly defined and highly complex. This study explored the use of geometric deep learning models to classify infrastructure BIM elements, with the ultimate goal of automating the prechecking of BIM-to-IFC mappings. Two models with proven classification performance, Multi-View Convolutional Neural Network (MVCNN) and PointNet, were trained and tested to classify 10 types of commonly used BIM elements in road infrastructure, using a dataset of 1496 3D models. Results revealed MVCNN as the superior model with ACC and F1 score values of 0.98 and 0.98, compared with PointNet's corresponding values of 0.83 and 0.87, respectively. MVCNN, which employs multiple images to learn the features of a 3D artifact, was able to discern subtle differences in their shapes and geometry. PointNet seems to lose the granularity of the shapes, as it uses points partially selected from point clouds.
Probing the cluster pressure profile with thermal Sunyaev–Zeldovich effect and weak lensing cross-correlation
Authors: Ma Yin-Zhe , Gong Yan , Tröster Tilman , Van Waerbeke Ludovic
Published: October 2020

We confront the universal pressure profile (UPP) proposed. with the recent measurement of the cross-correlation function of the thermal Sunyaev–Zeldovich (tSZ) effect from Planck and weak gravitational lensing measurement from the Red Cluster Sequence Lensing Survey. By using the halo model, we calculate the prediction of ξy−κ (lensing convergence and Compton-y parameter) and $\xi ^{y-\gamma _{\rm t}}$ (lensing shear and Compton-y parameter) and fit the UPP parameters by using the observational data. We find consistent UPP parameters when fixing the cosmology to either WMAP 9-yr or Planck 2018 best-fitting values. The best constrained parameter is the pressure profile concentration c500 = r500/rs, for which we find $c_{500} = 2.68^{+1.46}_{-0.96}$ (WMAP-9) and $c_{500} = 1.91^{+1.07}_{-0.65}$ (Planck-2018) for the $\xi ^{y-\gamma _t}$ estimator. The shape index for the intermediate radius region α parameter is constrained to $\alpha =1.75^{+1.29}_{-0.77}$ and $\alpha = 1.65^{+0.74}_{-0.5}$ for WMAP-9 and Planck-2018 cosmologies, respectively. Propagating the uncertainties of the UPP parameters to pressure profiles results in a factor of 3 uncertainty in the shape and magnitude. Further investigation shows that most of the signal of the cross-correlation comes from the low-redshift, inner halo profile (r ≤ rvir/2) with halo mass in the range of 1014–$10^{15}{\, {\rm M}_{\odot }}$, suggesting that this is the major regime that constitutes the cross-correlation signal between weak lensing and tSZ.
The [O iii]+H β equivalent width distribution at z ≃ 7: implications for the contribution of galaxies to reionization
Authors: Endsley Ryan , Stark Daniel P , Chevallard Jacopo , Charlot Stéphane
Published: October 2020

We quantify the distribution of [O iii]+H β line strengths at z ≃ 7 using a sample of 20 bright ($\mathrm{M}_{\mathrm{UV}}^{}$ ≲ –21) galaxies. We select these systems over wide-area fields (2.3 deg2 total) using a new colour-selection that precisely selects galaxies at z ≃ 6.63–6.83, a redshift range where blue Spitzer/IRAC [3.6]−[4.5] colours unambiguously indicate strong [O iii]+H β emission. These 20 galaxies suggest a lognormal [O iii]+H β EW distribution with median EW = 759$^{+112}_{-113}$ Å and standard deviation = 0.26$^{+0.06}_{-0.05}$ dex. We find no evidence for strong variation in this EW distribution with UV luminosity. The typical [O iii]+H β EW at z ≃ 7 implied by our sample is considerably larger than that in massive star-forming galaxies at z ≃ 2, consistent with a shift towards larger average sSFR (4.4 Gyr−1) and lower metallicities (0.16 Z⊙). We also find evidence for the emergence of a population with yet more extreme nebular emission ([O iii]+H β EW > 1200 Å) that is rarely seen at lower redshifts. These objects have extremely large sSFR (>30 Gyr−1), as would be expected for systems undergoing a burst or upturn in star formation. While this may be a short-lived phase, our results suggest that 20 per cent of the z ≃ 7 population has such extreme nebular emission, implying that galaxies likely undergo intense star formation episodes regularly at z > 6. We argue that this population may be among the most effective ionizing agents in the reionization era, both in terms of photon production efficiency and escape fraction. We furthermore suggest that galaxies passing through this large sSFR phase are likely to be very efficient in forming bound star clusters.
On the torque reversals of accreting neutron stars
Authors: Ertan Ünal
Published: October 2020

We have extended the analytical model proposed earlier to estimate the inner disc radius of accreting neutron stars in the strong-propeller (SP) phase, and the conditions for the transitions between the strong and weak propeller (WP) phases (Ertan 2017, 2018) to the WP (accretion with spin-down) and the spin-up (SU) phases, and the torque reversals during the WP/SU transitions. The model can account for some basic observed properties of these systems that are not expected in conventional models: (1) accretion on to the star at low X-ray luminosities and the transitions to the SP phase (no accretion) at critical accretion rates much lower than the rate required for the spin-up/spin-down transition, (2) ongoing accretion throughout a large range of accretion rates while the source is spinning down (WP phase), and (3) transitions between the spin-up and spin-down phases with comparable torque magnitudes, without substantial changes in the mass-flow rate. Our results indicate that the magnitudes of the torques on either side of the torque reversal have a ratio similar for different systems independently of their spin periods, magnetic dipole moments, and accretion rates during the transitions. Estimated torque reversal properties in our model are in agreement with the observed torque reversals of 4U 1626–67.
Evolution of ion acoustic solitary waves in pulsar wind
Authors: Singh Kuldeep , Kakad Amar , Kakad Bharati , Saini Nareshpal Singh
Published: October 2020

We have studied the evolution of ion acoustic solitary waves (IASWs) in pulsar wind. The pulsar wind is modelled by considering a weakly relativistic unmagnetized collisionless plasma comprised of relativistic ions and superthermal electrons and positrons. Through fluid simulations, we have demonstrated that the localized ion density perturbations generated in the polar wind plasma can evolve the relativistic IASW pulses. It is found that the concentration of positrons, relativistic factor, superthermality of electrons, and positrons have a significant influence on the dynamical evolution of IASW pulses. Our results may provide insight to understand the evolution of IASW pulses and their role in astrophysical plasmas, especially in the relativistic pulsar winds with supernova outflow, which is responsible for the production of superthermal particles and relativistic ions.
Tidally induced stellar oscillations: converting modelled oscillations excited by hot Jupiters into observables
Authors: Bunting Andrew , Terquem Caroline
Published: October 2020

We calculate the conversion from non-adiabatic, non-radial oscillations tidally induced by a hot Jupiter on a star to observable spectroscopic and photometric signals. Models with both frozen convection and an approximation for a perturbation to the convective flux are discussed. Observables are calculated for some real planetary systems to give specific predictions. The photometric signal is predicted to be proportional to the inverse square of the orbital period, P−2, as in the equilibrium tide approximation. However, the radial velocity signal is predicted to be proportional to P−1, and is therefore much larger at long orbital periods than the signal corresponding to the equilibrium tide approximation, which is proportional to P−3. The prospects for detecting these oscillations and the implications for the detection and characterization of planets are discussed.
Revisiting migration in a disc cavity to explain the high eccentricities of warm Jupiters
Authors: Debras Florian , Baruteau Clément , Donati Jean-François
Published: October 2020

The distribution of eccentricities of warm giant exoplanets is commonly explained through planet–planet interactions, although no physically sound argument favours the ubiquity of such interactions. No simple, generic explanation has been put forward to explain the high mean eccentricity of these planets. In this paper, we revisit a simple, plausible explanation to account for the eccentricities of warm Jupiters: migration inside a cavity in the protoplanetary disc. Such a scenario allows to excite the outer eccentric resonances, a working mechanism for higher mass planets, leading to a growth in the eccentricity while preventing other, closer resonances to damp eccentricity. We test this idea with diverse numerical simulations, which show that the eccentricity of a Jupiter-mass planet around a Sun-like star can increase up to ∼0.4, a value never reached before with solely planet–disc interactions. This high eccentricity is comparable to, if not larger than, the median eccentricity of warm Saturn- to Jupiter-mass exoplanets. We also discuss the effects such a mechanism would have on exoplanet observations. This scenario could have strong consequences on the disc lifetime and the physics of inner disc dispersal, which could be constrained by the eccentricity distribution of gas giants.
HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine
Authors: Fang ShuangSang , Dong Lei , Liu Liu , Guo JinCheng , Zhao LianHe , Zhang JiaYuan , Bu DeChao , Liu XinKui , Huo PeiPei , Cao WanChen , Dong QiongYe , Wu JiaRui , Zeng Xiaoxi , Wu Yang , Zhao Yi
Published: October 2020

Pharmacotranscriptomics has become a powerful approach for evaluating the therapeutic efficacy of drugs and discovering new drug targets. Recently, studies of traditional Chinese medicine (TCM) have increasingly turned to high-throughput transcriptomic screens for molecular effects of herbs/ingredients. And numerous studies have examined gene targets for herbs/ingredients, and link herbs/ingredients to various modern diseases. However, there is currently no systematic database organizing these data for TCM. Therefore, we built HERB, a high-throughput experiment- and reference-guided database of TCM, with its Chinese name as BenCaoZuJian. We re-analyzed 6164 gene expression profiles from 1037 high-throughput experiments evaluating TCM herbs/ingredients, and generated connections between TCM herbs/ingredients and 2837 modern drugs by mapping the comprehensive pharmacotranscriptomics dataset in HERB to CMap, the largest such dataset for modern drugs. Moreover, we manually curated 1241 gene targets and 494 modern diseases for 473 herbs/ingredients from 1966 references published recently, and cross-referenced this novel information to databases containing such data for drugs. Together with database mining and statistical inference, we linked 12 933 targets and 28 212 diseases to 7263 herbs and 49 258 ingredients and provided six pairwise relationships among them in HERB. In summary, HERB will intensively support the modernization of TCM and guide rational modern drug discovery efforts. And it is accessible through http://herb.ac.cn/.
Asian and Asian American Suburbs in the United States
Authors: Zarsadiaz James
Published: October 2020

Asians and Asian Americans are the most suburbanized people of color in the United States. While Asians and Asian Americans have been moving to the metropolitan fringe since the 1940s, their settlement accelerated in the 1970s, 1980s, and 1990s. This was partly the result of relaxed US immigration policies following the 1965 Hart-Celler Act. Globalization and burgeoning transnational economies across the so-called Pacific Rim also encouraged outmigration. Whether it is Korean or Indian immigrants in northern New Jersey or Vietnamese refugees in suburban Houston, Asians and Asian Americans have shifted Americans’ understandings of “typical” suburbia. In the late 1980s, academic researchers and policymakers started paying closer attention to this phenomenon, especially in Southern California, where Asians and Asian Americans often clustered together in select suburbs. Sociologists, in particular, observed how greater Los Angeles’s economic, political, and built landscapes changed as immigrants and refugees—predominantly from Hong Kong, Taiwan, the Philippines, South Korea, India, and Vietnam—established roots throughout the region, including Orange County. Since then, other studies of heavily populated Asian and Asian American ethnic suburbs—or “ethnoburbs”—have emerged, including research on New York City, Boston, and Washington, DC. Nonetheless, scholarship remains focused on Southern California, the San Francisco Bay Area, and other hubs of the metropolitan West Coast. Research and scholarship on Asians and Asian Americans living in the suburbs has grown over the last decade. This is partly a response to demographic shifts occurring beyond the coasts. Moreover, geographers, historians, and urban planners have joined the discussion, producing critical studies on race, class, architecture, and political economy. Despite the breadth and depth of recent research, literature on Asian and Asian American suburbanization remains limited. There is thus much room for additional research on this subject, given a majority of Asians and Asian Americans in the United States live outside city limits.
William Tell
Authors: Lerner Marc H.
Published: October 2020

William Tell (Wilhelm, Guillaume) is the name of a legendary Swiss hero from Canton Uri in the present-day Swiss Confederation. From the first recorded appearances of Tell in the late 15th century until the Revolutionary Era of the late 18th century, the symbol of William Tell has been used in a variety of ways to shape the cultural mythology of Switzerland, Europe, and the Atlantic world. According to a variety of Swiss foundation myths, Tell stood up to tyranny in the late 13th or early 14th century and helped secure Swiss liberty by defeating (or helping to defeat) the tyrant known as Gessler. Most of the tales present Tell as a humble, virtuous citizen of the canton who refused to bow down to the arbitrary symbols of a tyrant’s authority. In reaction to Tell’s defiance, the tyrant forced Tell to shoot an apple off Tell’s son’s head, promising both father and son their freedom if Tell were successful. However, upon discovering a second arrow hidden on Tell’s person, which threatened the tyrant, Gessler tried to imprison Tell. A sudden storm, possibly divinely inspired, allowed Tell to escape the ship with his life and kill Gessler in revenge, while a Swiss uprising overthrew the tyrannical government. Differences in content and interpretation of the various Tell stories result from the answers to several questions: Did Tell plan and lead the revolt? Did he take part in the foundational oath at the Rütli Meadow, the mythical birthplace of the Swiss Republics? Did the revolt target local aristocrats or a foreign tyrant? Usually the Tell story broke into two camps: one supporting the elite leadership of the Swiss republics, and the other demanding more popular sovereignty. In this breakdown, Tell either acted in defense of his family against the foreign tyrant or sought to overthrow local, aristocratic rule, signaling a more popular rebellion. Eventually, these interpretations were easily expanded beyond Swiss boundaries and were used to support or challenge elite-led governments outside the Swiss Republics. During the Revolutionary Era, the figure of Tell evolved into a transnational proxy in an ongoing battle between those who saw true liberty as self-rule, free from the intervention of foreigners, and those who saw liberty as an egalitarian principle, available to the entire male citizenry.
Peacebuilding and Communication
Authors: Baú Valentina
Published: October 2020

As a result of its interdisciplinarity, that of peacebuilding and communication is an exceptionally diverse field, which encompasses many stimulating and creative subfields. Differences and similarities between them are grounded in the combination of theoretical frameworks that are adopted, and which become the backbone for both research and practice. Some of these areas are still emerging scholarships, with a need to integrate more consistently existing practical experiences with conceptual models developed through exploratory methods. The applied nature of peacebuilding and communication makes the grey literature in this field, comprising nongovernmental organizations’ (NGO) reports and publications from other nonacademic actors, also noteworthy. Research in this area borrows from media studies, development studies, peace and conflict studies, sociology, psychology, and technology studies. With such diversity in mind, the sections want to be representative of the exciting landscape that this field embodies.
The Northwest Coast
Authors: Tepper Leslie H.
Published: October 2020

The distinctive culture of the Indigenous populations on the Northwest Coast (NWC) and their colonial history—from European contact in the 17th century to contemporary issues of land claims and reconciliation—have helped to frame many of the themes and models of ethnographic theory and practice, particularly in American anthropology. The NWC is often defined as the geographic area stretching from Alaska to California. For the purposes of this bibliography, the study area is limited to what is sometimes called the “North Pacific Coast,” which begins at the southern border of Alaska, continues down the coastline of British Columbia (BC), and ends in northern Washington State. Its rocky coastline is broken up by deep fjords and offshore islands, including Vancouver Island in the south and Haida Gwaii (formerly the Queen Charlotte Islands) in the north. Several major river systems provide access to the BC interior through the mountainous Cascade Range. Though local resources vary along the coast, almost all the Indigenous groups followed a similar seasonal cycle of fishing, hunting, and gathering from spring to fall. The winter months were dedicated to the manufacture of material culture, social feasting, and ceremonial gatherings. Large oceangoing canoes and smaller river crafts linked well-established villages into an extensive series of trade routes. Walking trails over the mountains allowed the exchange of seafood and other coastal products for animal skins and goods from interior forests. Warfare brought additional wealth to the victor by means of raiding stored foods and manufactured items. European contact began in the late 18th century with the arrival of Spanish and British explorers. They were followed by English, American, and Russian fur traders. The discovery of gold along the Fraser River in 1858, and later finds in the Cariboo Mountains, brought tens of thousands of American, British, and other immigrants to the area. British sovereignty over the area north of the 49th parallel was quickly reinforced by the Royal Navy and an expanded colonial administration. In 1871 the province of British Columbia joined the Canadian Confederation and NWC Indigenous communities came under the control of the federal Indian Act. This act is still in force.
Mad Men
Authors: Edgerton Gary
Published: October 2020

Once or twice a decade, a new television program comes along to capture and express the zeitgeist. Mad Men (2007–2015) was that show in the late 2000s and early 2010s. Soon after premiering on the 19 July 2007 on AMC (formerly American Movie Classics from 1984 to 2003), Mad Men evolved from being that little program that nobody watched on an also-ran basic cable channel to the most celebrated scripted drama of its era. Mad Men set the creative standard for dramatic series over the span of its initial run. It was recognized by the Hollywood Foreign Press Association as the Best Television Drama of 2007, 2008, and 2009; the British Academy of Film and Television as Best International Show of 2009 and 2010; and the National Academy of Television Arts and Sciences as the Outstanding Drama Series of 2008, 2009, 2010, and 2011, being the first basic cable series ever to win this award. Overall, Mad Men won five Golden Globes, sixteen Emmys, and fifty other major awards, including honors from all of the major Hollywood guilds, as well as receiving a prestigious George Foster Peabody Award for excellence in broadcasting. In retrospect, AMC executives adopted what they referred to as “the HBO formula” of developing their own edgy, sophisticated, passion project by a proven writer-producer, Matthew Weiner, who just happened to have a pedigree that included The Sopranos (HBO, 1999–2007). What resulted was the gradual emergence of Mad Men as AMC’s first original hit series, generating unprecedented word-of-mouth, and rebranding the channel as a hipper, more discriminating, alternative cable-and-satellite network. In turn, Mad Men broke the glass ceiling for basic cable in much the same way that The Sopranos had done for pay TV some eight-and-a-half years earlier. Mad Men also benefited greatly from the emergence of multiplatform reception. Even though Mad Men’s impact on AMC was immediate and transformative, the show was at first more a cultural phenomenon than a breakout hit. Nevertheless, its first-season audience average of 900,000 on AMC in 2007 eventually grew to 2.5 million by Season 6. Moreover, Mad Men’s total viewership relied heavily on syndication, DVDs, and streaming to digital devices, translating into an estimated 30 million unduplicated viewers per episode in North America alone. By the time of its finale on 17 May 2015, Mad Men was being syndicated in over fifty countries and was available 24/7 through online streaming globally.
Corporate Liability Design for Human Rights Abuses: Individual and Entity Liability for Due Diligence
Authors: Friedman Nick
Published: October 2020

In this article, I critically review the economic theory of corporate liability design, focusing on the allocation of liability between a corporation and its individual human agents. I apply this theory to transnational commercial contexts where human rights abuses occur and assess the likely efficacy of some putative liability regimes, including regimes requiring corporations to undertake human rights due diligence throughout their global supply chains. I advance a set of general considerations justifying the efficacy of due diligence in relation to alternative liability regimes. I argue, however, that due diligence regimes will likely under-deter severe human rights abuses unless they are supported by substantial entity-level sanctions and, in at least some cases, by supplementary liability for individual executives. The analysis has significant policy implications for current national and international efforts to enforce human rights norms against corporations.
What Would You Do with $500? Spending Responses to Gains, Losses, News, and Loans
Authors: Fuster Andreas , Kaplan Greg , Zafar Basit
Published: October 2020

We use survey questions about spending in hypothetical scenarios to investigate features of propensities to consume that are useful for distinguishing between consumption theories. We find that (1) responses to unanticipated gains are vastly heterogeneous (either zero or substantially positive); (2) responses increase in the size of the gain, driven by the extensive margin of spending adjustments; (3) responses to losses are much larger and more widespread than responses to gains; and (4) even those with large responses to gains do not respond to news about future gains. These four findings suggest that limited access to disposable resources, and frictions in adjusting consumption, are important determinants of consumption behaviour. We also find that (5) households do not respond to the offer of a one-year interest-free loan, suggesting that this is not a consequence of short-term credit constraints; and (6) people do cut spending in response to news about future losses, suggesting that neither is this a consequence of myopia. A calibrated precautionary savings model with utility costs of changing consumption, and a sufficient fraction of low-wealth households, can account for these features of propensities to consume on both the extensive and intensive margins.
The Role of Internal M&A Teams in Takeovers
Authors: Aktas Nihat , Boone Audra , Witkowski Alexander , Xu Guosong , Yurtoglu Burcin
Published: October 2020

This article provides insights into the inner workings of internal corporate M&A teams using survey evidence from sixty-five firms from Austria, Germany, and Switzerland. We find that internal teams create value, especially relative to external advisors, by directing transaction rationales, screening targets, and employing performance metrics to assess post-merger success. Teams emphasizing economic rationales as a merger motive are associated with higher returns than those teams more apt to consider behavioral motives. We consider several team characteristics and find that financial experience is the most persistent and significant attribute in explaining the outcomes across various deal stages. Another key result from our survey-based evidence is that latent M&A team factors explain ∼54% of the acquirer fixed effects in announcement return regressions.
A novel computer navigation model guided unilateral percutaneous vertebroplasty for vertebral compression fracture
Authors: Xu Hao-Tian , Zheng Shuang , Kang Ming-Yang , Yu Tong , Zhao Jian-Wu
Published: October 2020

Rational:

Vertebral compression fracture (VCF) is one of the most common diseases in spinal surgery. Traditional percutaneous vertebroplasty (PVP) under fluoroscopy is an effective method to treat vertebral compression fracture. However, there is still a risk of vascular nerve injury and infection caused by inaccurate or repeated puncture. Therefore, the purpose of this paper was to assess the accuracy of unilateral PVP guided by screw view model of navigation (SVMN) for VCF.

Patient concerns:

A 59-year-old female patient suffered high falling injury, and with back pain as its main clinical symptom.

Diagnoses:

The patient was diagnosed with a L1 VCF.

Interventions:

We placed the puncture needle under the guidance of SVMN to reach the ideal position designed before operation, and then injected the bone cement to complete the percutaneous kyphoplasty (PKP).

Outcomes:

The operative time was 29.5 minutes, the puncture time was 1 time, the fluoroscopy time was 2.9 minutes, and the bone cement distribution was satisfactory. VAS and ODI scores were significant improved postoperatively. No surgical complications, including neurovascular injury and infection, were observed during 28-month follow up.

Lessons:

The SVMN guided percutaneous puncture needle insertion in PKP operation for VCF is an effective and safety technique. Besides, the SVMN has also been a contributor to reduce radiation doses and replace conventional fluoroscopy.
Receptor for advanced glycation end-product rs1800624 polymorphism contributes to increase breast cancer risk
Authors: Zhang Wei , Deng Xiaowei , Tang Ruijun , Wang Hong
Published: October 2020

Background:

Although several studies have identified an association between the receptor for advanced glycation end-product (RAGE) rs1800624 polymorphism and breast cancer, the results have been conflicting. Therefore, we conducted a meta-analysis to assess the relationship between the RAGE rs1800624 polymorphism and breast cancer risk.

Methods:

Studies were searched in the PubMed, Web of Science, Embase, Wanfang Med Online, and China National Knowledge Infrastructure databases until September 20, 2019 to identify all potential literature on this association. Fixed-effect or random-effect models were used to calculate odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs). Subgroup and sensitivity analyses and tests for publication bias were also performed.

Results:

Five eligible studies involving 2823 subjects (1410 patients and 1413 healthy controls) were included in the current meta-analysis. The pooled analysis indicated a positive correlation between the RAGE rs1800624 polymorphism and the risk of breast cancer in a homozygous genetic model (OR = 1.423, 95% CI = 1.043–1.941, P = .026). Ethnicity-based subgroup analysis demonstrated that RAGE rs1800624 polymorphism may increase the risk of breast cancer in the Asian population in homozygous model (OR = 1.661, 95% CI = 1.178–2.342, P = .004).

Conclusion:

The RAGE rs1800624 polymorphism may increase the risk of breast cancer in the homozygous genetic model, especially in Asian populations. Large-scale and well-designed studies are needed in different populations to further evaluate the role of the RAGE polymorphism in breast cancer.