bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards a uniform definition for the centralisation phenomenon
Authors: Χόρτη Αγγελική
Published: May 2024

Η εστίαση αυτού του διδακτορικού έργου είναι στην επικέντρωση των συμπτωμάτων. Ο αρχικός σκοπός του ήταν να καθοριστεί ένας τυπικός λειτουργικός ορισμός της επικέντρωσης και να εκτιμηθεί η αξιοπιστία μεταξύ των εξεταστών στην αυχεναλγία. Δύο συστηματικές ανασκοπήσεις πάνω στην αξιοπιστία και την προγνωστική αξία των κλινικά προκαλούμενων συμπτωματικών ανταποκρίσεων στο σπονδυλικό πόνο (Κεφάλαια 2 και 3) έδειξαν ότι παρότι η εν δυνάμει χρησιμότητα της επικέντρωσης έχει φανεί στην οσφυαλγία, έχει εκφραστεί ανησυχία σχετικά με την παρατηρούμενη ασυνέπεια στους αναφερόμενους ορισμούς, και την έλλειψη επαρκών μελετών για την αυχεναλγία. Μια δημοσκόπηση τύπου Delphi ειδικών πάνω στο θέμα (Κεφάλαιο 4) συνέβαλε στην ανάπτυξη ενός καθολικού λειτουργικού ορισμού για την επικέντρωση και τον καθορισμό μελλοντικών ερευνητικών ερωτημάτων. Η επικέντρωση ορίστηκε γενικά ως η προοδευτική και σταθερή υποχώρηση του περιφερικότερου εκδηλωμένου πόνου προς τη σπονδυλική μέση γραμμή ως αποτέλεσμα τυποποιημένων στρατηγικών σπονδυλικής φόρτισης. Η υποστήριξη από την ομάδα των ειδικών της μελέτης Delphi ενός ευρύτερου ορισμού επέτρεψε την συμπερίληψη πληθώρας διαφορετικών τρόπων ελέγχου στη διαδικασία αξιολόγησης κάτι που μπορεί να προσφέρει κάποιου βαθμού ευελιξία στους κλινικούς που αξιολογούν, ταξινομούν και αντιμετωπίζουν διάφορες εκδηλώσεις σπονδυλικού πόνου στις διάφορες χώρες. Παρότι ο βαθμός αξιοπιστίας του εντοπισμού της επικέντρωσης ήταν αποδεκτός, δεν βρέθηκαν υψηλά επίπεδα αξιοπιστίας (Κεφάλαιο 5). Ωστόσο, η αξιοπιστία ήταν μεγαλύτερη για το ζευγάρι των φυσικοθεραπευτών με προγενέστερη εμπειρία και επίσημη εκτεταμένη εκπαίδευση στην αξιολόγηση της συμπτωματικής ανταπόκρισης. Επομένως, ο ιδανικός τύπος και ο βαθμός της εκπαίδευσης για την πρόκληση και την ερμηνεία της επικέντρωσης καθώς και η επίδραση των αποκλίσεων στη διαδικασία πάνω στα αποτελέσματα των ατόμων που επικεντρώνουν συμπτώματα απαιτεί επείγουσα διερεύνηση. Η προγνωστική και θεραπευτική αξία της επικέντρωσης είναι επίσης άγνωστες. Η έρευνα αυτή είναι δυνατό να δημιουργήσει τη βάση για την τυποποίηση της επικέντρωσης ως σημείο της φυσικής εξέτασης και να διεγείρει το ενδιαφέρον για περαιτέρω μελέτη πιθανών υπο-ομάδων και ταξινομήσεων των σπονδυλικών συνδρόμων.
Clinical efficacy of titanium prepared platelet rich fibrin in periodontal regeneration: A systematic review and meta-analysis
Authors: Oza Dr. Ranu , Dhadse Dr. Prasad , Bajaj Dr. Pavan , Bhombe Dr. Komal , Durge Dr. Khushboo , Subhadarsanee Dr. Chitrika , Hassan Dr. Safiya
Published: May 2024

Background Periodontal regeneration therapies frequently involve autologous platelet concentrates (APCs). They can be used in sinus lift surgeries and socket preservation, among other clinical settings. Platelet rich fibrin (PRF) membrane has been used to treat gingival recession in individuals or groups of individuals using a coronally progressed or lateral pedicle flap. In the treatment of mixed periodontic endodontic lesion/furcation defect, PRF functions as a healing and interpositional biomaterial, filling a cystic cavity. PRF is known to help the bone regeneration process. In the last few years, efforts have been made to enhance the PRFs characteristics and quality. One of them is titanium platelet rich fibrin (T-PRF). Third-generation platelet concentrate no longer contains silica, and its preparation in glass vacuum containers, that no longer creates any known concerns. The effectiveness PRF’s has been evaluated in connective tissue and bone repair. The aim of this study is to compare T-PRF to other platelet concentrates and different treatment modalities for periodontal regenerative procedures. Methods A protocol of this systematic review have been registered in prospero (CRD42022293545). The online database searched were PUBMED, COCHRANE for published articles up to November 2022 without language restrictions. Studies in trial registers, handsearching, bibliographic references of relevant articles were also checked. Data collection and analysis was done by individual authors. Independent eligibility assessments were conducted by four review authors. Then, using the standard Cochrane methodology, four review authors extracted the data and evaluated the risk of bias for individual studies. We developed “Summary of findings” tables and used GRADE to evaluate the evidence. Results Three studies were included for meta-analysis. Results of meta-analysis supported that T-PRF is effective for correction of both hard and soft tissue defects. Conclusions The overall qualitative and quantitative analysis suggest that T-PRF has superior structural properties and thicker fibrin network for ensuring predictable success periodontal regenerative procedures.
Challenges and opportunities in the uptake of simulation in healthcare education in the developing world: a scoping review
Authors: Ismail Faisal W. , Ajani Khairulnissa , Baqir Syed Mujtaba , Nadeem Ahmed , Qureshi Rayyan , Petrucka Pammla
Published: May 2024

Background Simulation is increasingly being adopted by healthcare educators throughout the developed world as it offers a safe environment to practice skills. While there is literature on learning via simulation in healthcare in the developed world, more studies are required to investigate the factors influencing this approach in the developing world. Objective This scoping review highlights the key factors that act as deterrents as well as encouragement to the uptake of simulation as a teaching methodology in healthcare education in developing countries. Design The MEDLINE (via OVID, using keywords and MeSH in OVID), and PubMed (via NCBI using MeSH), and CINAHL databases were searched between January 2000 and January 2024 for research articles published in peer reviewed English language journals using a combination of keywords. Results A total of 48 articles were included in the final analysis. Challenges and opportunities were divided into professional, academic, and resource-based factors, and their individual sub-themes. The main challenges reported were the lack of a contextual curriculum, content heavy curricula, dearth of trained simulationists and cost of simulators. Performance anxiety was an important challenge reported by both trainers and trainees. Main opportunities were an interest in adopting simulation-based education from both trainers and trainees, and the opportunity to improve patient safety and quality of education. Other findings were that academic leadership and faculty show interest and urgency to adopt simulation in curricula and allocate funds for this. Facilitators need to be provided with protected time to become simulationists. Local manufacturers need to be sourced for simulators, and transfer of technology and expertise needs to be negotiated. Conclusion Simulation needs to be looked at from the lens of not only education, but more importantly of patient safety in developing countries to allow simulation-based education to be mainstreamed in health professions education in low- and middle-income contexts.
The genome sequence of the Common Carpet moth, Epirrhoe alternata (Müller, 1764)
Authors: Boyes Douglas , Crowley Liam M. , Hutchinson Finley , Wawman Denise C. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: May 2024

We present a genome assembly from an individual male Epirrhoe alternata (the Common Carpet; Arthropoda; Insecta; Lepidoptera; Geometridae). The genome sequence is 358.5 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 16.99 kilobases in length.
Przestrzeń kosmiczna i zapowiedź nowego nomosu ziemi
Authors: Jabłoński Michał
Published: May 2024

This work is an attempt to theoretically frame the importance of space exploration for the future political order in the context of the growing importance of information processing. In reference to A. Toffler, G. W. F. Hegel, and C. Schmitt, I show one of the possible ways of periodizing the history of humanity, along with an attempt to demonstrate that each period has a desirable form of existence of a political entity based on a specific physical space that is most conducive to the dominant social activity at a given time. I argue that in a civilization in which the main activity is information processing, the desired form of existence of a political entity may be an existence that assumes outer space as its central space, as the one in which the political entity is most active. I also try to find an answer to the question whether space exploration can lead to the formation of a new basic spatial form in international relations, other than the state.
Philosophical foundations of worldview conflict within Western thought in the conservative perspective
Authors: Kądzielska Maria
Published: May 2024

Abstract:
In the face of growing conflicts in Western societies and the formation of deep political, ideological and worldview divisions within Western civilization, it becomes legitimate to ask whether we are not witnessing ongoing culture wars? The observed intensifying social dichotomies do not touch only the issue of political sympathies or antipathies, but concern almost all aspects of human life: the concept of nation, attitude to religion, family model, approach to sexuality and even the existence of gender. The purpose of this article is to trace the conservative style of thinking in the context of the culture war, to distinguish the elements of common concepts within this philosophical tradition, as well as the peculiarities of each of the selected authors. The paper has the following order: an introduction devoted to the origins of modern conservatism, allowing to outline the conceptual framework of this style of thinking. It is hypothesized that modern British conservatism arose in response to events associated with the collapse of socialism in Poland and Czechoslovakia, while the philosophical development of Polish conservative thought is inspired by Anglo-Saxon publications. In the first part, the thought of British conservative philosophy on the phenomenon of culture war is described on the example of Roger Scruton's philosophy, and then compared with American authors Allan Bloom and Gertrude Himmelfarb. The second part of the article is devoted to two Polish authors who have dealt extensively with the subject of culture war – Agnieszka Kolakowska and Anna Pawczynska. Finally, the conservative interpretation of the culture war is compared with the liberal and left-wing interpretations in order to point out the links, connections, as well as differences between them.
Jornalismo nas redes digitais ribeirinhas no Amazonas: a experiência do canal educativo Amazônia Ribeirinha na produção de vídeos na plataforma do YouTube
Authors: Neves Soriany
Published: May 2024

O artigo mostra o percurso da produção de conteúdo do canal educativo Amazônia Ribeirinha na plataforma do YouTube. O canal nasceu com uma perspectiva de produção alternativa, colaborativa e em rede durante a Covid-19, com a produção de notícias, webséries, documentários e vídeos educativos. O propósito foi apostar em uma produção mais próxima das realidades locais, com destaque para as histórias, protagonismos e resistências das populações tradicionais (indígenas, quilombolas, ribeirinhos). Diante da escassez de notícias na região, principalmente no interior do Amazonas, onde o acesso é difícil, tendo o rio como único caminho às populações da região; e observando as multiplicidades de compreensão da Amazônia no Baixo Amazonas. Para tanto, os autores principais que nortearam o artigo foram Jenkis (2008), Martino (2015), Neves (2019), dentre outros. Quanto à metodologia tomou-se uma pespectiva de produção colaborativa em rede para a produção dos vídeos, com a participação das populações ribeirinhas e do ponto de vista de concepção e abordagem assentou-se nos pressupostos do método etnográfico e de uma perspectiva decolonial da seleção dos temas e entrevistados. O trabalho mostrou as possibilidades de produzir com dispositivos móveis, de baixo custo e a experimentação na produção de novas formas de narrar a Amazônia.
Enlistado: análisis del dilema moral en La lista de Schindler de Steven Spielberg
Authors: Hernández Ospino Álvaro David
Published: May 2024

A continuación, se propone el análisis del dilema moral que afronta el Oskar Schindler construido por Steven Spielberg en la película La lista de Schindler. Esta labor se lleva a cabo, principalmente, a través de la conceptualización de la compasión realizada por Martha Nussbaum en su libro Paisajes del pensamiento. Además, encuentra soporte en el análisis que del Tercer Reich y la Shoah hace Jonathan Glover.
Contribución tecnológica al acceso a la justicia: un chatbot para el agenciamiento de necesidades jurídicas
Authors: Astudillo Fernández Guillermo Efraín , Ávila Mahecha Lizette Daniela , Bernhard Noguera Stephanie Pamela , Fragozo Oñate María Laura , Garay Nuncira Andrés Camilo , Jiménez Zuluaga Luisa Fernanda , Motta Burbano María José , Prada Vanegas Diana Geraldine
Published: May 2024

Desde la perspectiva de las necesidades jurídicas, el acceso a la justicia comprende, entre otros mecanismos y condiciones, el garantizar que las personas y comunidades puedan agenciar sus necesidades jurídicas con miras a satisfacerlas. Sin embargo, en Colombia esta posibilidad se ve truncada por múltiples barreras, entre las cuales destacan la ausencia de conocimiento y falta de orientación a las que se deben enfrentar las personas —particularmente aquellas que se encuentran en una situación de vulnerabilidad— a la hora de gestionar sus necesidades jurídicas. Al entender estas barreras como problemas de comunicación, este proyecto indaga sobre la aplicación de tecnologías de la información y la comunicación (tic) en la creación de una alternativa que les haga frente y tenga un impacto social. En esa medida, se propone el desarrollo de un chatbot jurídico basado en inteligencia artificial como herramienta viable e innovadora que permita cerrar esa brecha de conocimiento y orientación, aportando al agenciamiento de las necesidades jurídicas por parte de las personas y, con ello, al acceso a la justicia.
Capítulo 1. La tienda de barrio
Authors: Medina Rojas Iván Darío , Rodríguez Lesmes Paul Andrés
Published: May 2024

Por tal motivo, la propuesta presentada propende a generar un acercamiento de la siguiente forma. El primer capítulo realiza un abordaje desde la etiología y el papel de las tiendas de barrio como eje de referencia, al ser por antonomasia un agente clave de la economía que se encuentra implícito en las relaciones socioeconómicas de las personas y que funge como un catalizador de las relaciones de mercado en sus escenarios más locales. El segundo capítulo hace una aproximación a la configuración de estos microestablecimientos, al igual de quien oficia como tendero, bajo la lupa del emprendimiento y la informalidad, como características inherentes en su configuración. El tercer capítulo toma como nivel de referencia la tienda de barrio dentro de un conjunto de sistemas que interactúan entre sí, en un proceso de constante coevolución con el entorno que le atribuye rasgos específicos a lo largo del tiempo. El cuarto capítulo trae a colación la descripción de la informalidad empresarial en economías en desarrollo, como es el caso de América Latina, África subsahariana y Asia-Pacífico. El quinto capítulo hace un acercamiento al plano local y describe el barrio como eje de construcción de tejido social, económico y cultural; la tienda de barrio se enmarca en el trasegar del barrio Minuto de Dios, sumado a un acercamiento a la caracterización de sus microestablecimientos. El sexto capítulo analiza las aristas que vinculan la transformación digital en los micronegocios en Colombia, fruto del ejercicio en campo que se lleva a cabo en el actual momento por parte de la Alianza Economía Formal e Inclusiva (efi). Y, finalmente, el séptimo capítulo recoge una conclusión general, una experiencia derivada de la actual coyuntura, de la afectación generada por el choque exógeno ocasionada por el sars-CoV-2 y de cómo se ha visto alterado el entorno socioeconómico del tendero de barrio; una reflexión general con análisis descriptivo en dos ciudades del país, Pereira e Ibagué, sobre lo vivido en los microestablecimientos en este periodo pandémico.
Capítulo 7. Perspectivas derivadas de la coyuntura generada por el sars-CoV-2
Authors: Medina Rojas Iván Darío , Guzmán Azuero Alexander , Cortés Núñez Lizeth Rocío , Rico Otálora Byron Armando , Montoya Ceballos Geraldine
Published: May 2024

En algún momento de su vida, Albert Einstein citó: “entre las dificultades se esconde la oportunidad”, y vaya que esa cita está más vigente que nunca. En el momento de la elaboración de este capítulo, la humanidad vive un episodio pandémico que ha obligado a sacar lo mejor de nosotros para poder salir adelante. A lo largo de la historia, el ser humano ha tenido que sopesar muchas situaciones adversas, en la actualidad un agente extremadamente pequeño y absolutamente imperceptible asusta por su rapidez, implacabilidad e impredecibilidad (Berretti, 2017), genera alteraciones al concepto de normalidad, trae cambios sustanciales al ritmo de vida y, por ende, a las relaciones sociales, económicas y ambientales. No obstante, no es nuevo hablar de afectación económica por agentes patógenos.
Correlación entre imagenología y anatomía humana
Authors: Cediel Juan Fernando , Villamil Angy Carolina
Published: May 2024

Es así como el propósito de esta guía es brindar la información necesaria para que el estudiante exprese adecuadamente sus observaciones y sus análisis de la información radiológica. Con este fin, se expondrán las bases necesarias para poder interpretar y reportar de manera básica las imágenes obtenidas por cuatro técnicas: la radiografía, la tomografía o escanografía, la resonancia magnética y la ecografía, así como sus características, principios y principales aplicaciones.
Digital vs. Traditional Advertising and the Recognition of Brand Intangible Assets
Authors: Song Scarlett Xiaotong
Published: May 2024

This paper examines how different advertising categories are associated with attributes of brand asset recognition arising in the context of acquisitions. Prior research documents that aggregate advertising is positively associated with firm sales and brand values, but it fails to consider major recent shifts in advertising from traditional channels (such as TV) to digital advertising (such as paid search and online display). Using proprietary data, I decompose advertising expenditures into the categories of traditional, online display, and paid search. Consistent with expectations, results confirm that target firms’ traditional and online display advertising exhibit a higher likelihood of brand asset recognition and higher recognized brand values as compared with paid search advertising. Confirming the economic substance of the recognized brands, additional results reveal positive investor equity market reactions to brand value, which are driven by firms investing more in traditional and online display advertising. Overall, these results confirm that certain advertising channels exhibit stronger associations with the recognition and characteristics of the underlying brand asset, consistent with their heterogeneous properties.

This paper was accepted by Suraj Srinivasan, accounting.

Funding: I acknowledge the financial support from my advisor, Eddie Riedl, as well as from the UNH Paul College of Business and Economics Summer Research Support Award.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00387 .
Proactive care for frailty
Authors: Hendry Anne , Law Ruth
Published: May 2024

Many providers aspire to scale up proactive care that prevents escalation of health and care needs, delays onset of disability, and reduces demand for emergency department attendance or admission to hospital or care home. NHS England offers guidance on personalised and coordinated multi-professional support and interventions for people with moderate or severe frailty. This article reflects on the growing international evidence for an integrated proactive approach for older people with frailty and why investing in high-quality, joined-up care for older people across the whole system improves outcomes for people, reduces demand for services, increases system resilience, and delivers economic and societal benefits. Facing up to frailty requires creative whole system workforce planning and development that will be challenging to deliver in the current financial and recruitment context yet all the more worthwhile as scaling up proactive care has the potential to be a game changer.
Introduction: The Muddy Roads of Shatila
Authors: Levin Geoffrey
Published: May 2024

The birth of the State of Israel in 1948 elicited relief and joy in Jewish communities throughout the United States and across the globe, having come only a few short years after the tragic events of the Holocaust. Yet as members of a minority group cognizant of persecution and oppression, some American Jews expressed interest and empathy for Palestinians after 750,000 of them lost their homes in the 1948 war. In the 1950s and 1960s, a small number of American Jewish individuals and organizations became directly involved in Palestinian affairs. This chapter introduces them, their motivations for action, and how other American Jews and Israelis responded to their involvement with Palestinian rights.
HINDFOOT ANKLE RECONSTRUCTION NAIL TRIAL (HARNT): POPULATION ANALYSIS OF SURGICAL TREATMENT OF COMPLEX ANKLE FRACTURES IN THE UNITED KINGDOM
Authors: Ahluwalia R. , Coffey D. , Reichert I. , Stringfellow T. , Wek C. , Tan Sze Ping
Published: May 2024

Introduction

The management of open or unstable ankle and distal tibial fractures pose many challenges. In certain situations, hindfoot nailing (HFN) is indicated, however this depends on surgeon preference and regional variations exist. This study sought to establish the current management and outcomes of complex ankle fractures in the UK.

Methods

A National collaborative study in affiliation with BOTA was conducted and data retrospectively collected between January 1st – June 30th 2019. Adult patients with open and closed complex ankle fractures (AO43/44) were included. Complex fractures included the following patient characteristics: diabetes ± neuropathy, rheumatoid arthritis, alcoholism, polytrauma and cognitive impairment. We obtained data on fixation choice and patient outcomes. Institutional approval was obtained by all centres, and statistical analysis was performed including propensity matching.

Results

Fifty-six centres provided data for 1360 patients. The average age of the cohort was 53.9 years ±19 (SD) with a male/female ratio of 1:1.3. 920 patients were ASA 1/2, 440 were ASA 3/4; 316 had diabetes, and 275 were open fractures. Most fractures were AO44 (71.2%) and more commonly associated with diabetes (P<0.001), alcoholism (P<0.007), open (P<0.013), and advanced age (55.7 vs. 46.3). 1227 patients underwent primary-fixation (111 HFN), with the remainder treated with external-fixation (84 definitive). Of the 111 HFN, 35% underwent primary fusion. Wound complication and thromboembolic rates were greater in the HFN group compared to ORIF groups (P<0.003), being more evident in the HFN group with primary fusion even after propensity matching. However, 1081 patients were non-weightbearing post-op contrary to the BOAST guidance.

Conclusion

This is the first National collaborative audit of complex ankle fractures. Hindfoot nails were used in 9% of patients and we observed more complications in this group when compared to other cohorts. Despite BOAST guidance, only 21% of patients undergoing operative management were instructed to fully weightbear post-operatively.
PEGADA HÍDRICA DA CARNE DE FRANGO NA REGIÃO DE FEIRA DE SANTANA – ETAPA DE CRIAÇÃO
Authors: Juliana de Almeida Moraes  , Eduardo Henrique Borges Cohim Silva
Published: May 2024

Dentre as proteínas animais consumidas mundialmente, a carne de frango está entre as mais presentes na dieta do brasileiro devido ao seu alto teor proteico, qualidade nutricional, custo e alta disponibilidade comercial. Segundo a EMBRAPA (2017), cada brasileiro consome cerca de 43kg de frango ao ano, considerando os processados, e o consumo dessa proteína vem crescendo ao longo dos anos.
Stable cones in the thin one-phase problem
Authors: Fernández-Real Xavier , Ros-Oton Xavier
Published: May 2024

abstract: The aim of this work is to study homogeneous stable solutions to the thin (or fractional) one-phase free boundary problem. The problem of classifying stable (or minimal) homogeneous solutions in dimensions $n\geq3$ is completely open. In this context, axially symmetric solutions are expected to play the same role as Simons' cone in the classical theory of minimal surfaces, but even in this simpler case the problem is open. The goal of this paper is twofold. On the one hand, our first main contribution is to find, for the first time, the stability condition for the thin one-phase problem. Quite surprisingly, this requires the use of ``large solutions'' for the fractional Laplacian, which blow up on the free boundary. On the other hand, using our new stability condition, we show that any axially symmetric homogeneous stable solution in dimensions $n\le 5$ is one-dimensional, \emph{independently} of the parameter $s\in (0,1)$.
Catholic Democrats and Comunione e Liberazione: Different Perspectives on Faith after the Second World War
Authors: Saresella Daniela
Published: May 2024

Abstract: In the period following World War II, the Catholic world in Italy was veined with different religious sensibilities and differing opinions on the thought of Maritain and the Second Vatican Council. This essay aims to analyze the experience of Azione Cattolica (AC), which, from the fifties onward in Milan, had to come to terms with the affirmation of the Gioventù Studentesca (GS) movement, founded by Don Luigi Giussani. The latter was an organization that considered educational) communities the primary sites for coming into contact with Jesus and judged the work of evangelization carried out by the parishes to be ineffective. Contrary to Maritain's distinction between the actions of a person "as a Christian," consisting in obedience to the rites and dogmas of the Church, implying acknowledgement of an independent area for lay organizations and an omincomprehensive vision of religion, GS (which, from 1970 onward took the name of Comunione e Liberazione [CL]), criticized those Catholics who, in the wake of the new inspiration coming from the Council, supported "mediation" with the modern world. These differences in viewpoint were to lead to disagreements with church policy and even polemics.
"A Disturber of Christians": The Life and Spirituality of Romeo Maione
Authors: Baltutis Peter E.
Published: May 2024

Abstract: During his lifetime, Romeo Maione (1925–2015) was widely regarded as one of Canada's most prominent Catholic advocates for social justice. As the first national President of the Young Christian Workers in Canada, he brought this movement into English Canada and challenged Catholic lay people to become more actively involved in the world. As the first Executive Director of Development and Peace-Caritas Canada, his dynamic leadership established the foundation for how this new nationwide movement would serve the world's poor. An innovative thinker, he was the catalyst for creating ecumenical coalitions for justice. His legacy was to "disturb" Canadian Catholics out of complacency and into action for others.
The (White) Child and the Dustin Inman Society: American Ethnonationalism, Masculine Protectionism, and Racialized Citizenship
Authors: Vandermeade Samantha L.
Published: May 2024

Abstract: Utilizing feminist discursive analysis, this article examines the public rhetoric and activism of the anti-immigrant group, the Dustin Inman Society (DIS), in order to analyze how and to what ends the DIS mobilizes the memory of a dead, White child in service of anti-immigrant animus. The article demonstrates that by positioning the rhetorical figure of the Child as an oracle of the national future, the DIS frames its anti-immigrant activism as nothing less than a struggle for the survival of the next generation of (White) Americans, of a sacred American-qua-White culture, and of the nation itself. This rhetorical, ideological, and affective framing of the White Child justifies and legitimizes a particular kind of ethnonationalist male protectionism against both the ‘illegal invasion’ of Latina/o immigrants and a feminized federal government. The DIS’s racist and gendered rhetoric simultaneously contributes to rising swells of White ethnonationalism and travels along preexisting channels of racism and White (masculine) supremacy that are carved deep into US society. This analysis reveals much about the complex interrelationships between White masculinity and ethnonationalism, xenophobia, and nativism, and about how these rhetorical framings aid in the (re)definition of American citizenship as racialized, able-bodied, genealogical, and above all, White.
More Than Curing the Sick: A Re-Examination of Medicine Buddha Worship in Medieval China
Authors: Chen Dixuan
Published: May 2024

Abstract: The study questions and challenges the dichotomous approach that associates the worship of Medicine Buddha solely with the worldly benefits of the living, thereby neglecting its relevance to the concerns related to the deceased. The research investigates medieval devotees’ religious activities dedicated to this divinity, focusing on the Sui (581–618) and the Tang (618–907) dynasties when such devotion gained increasing popularity in China. It reveals that medieval veneration dedicated to Medicine Buddha transcended the presumed dichotomy, encompassing the well-being of both the living and the dead. This finding underscores the importance of moving beyond the limited perception. Instead of adopting the simplistic label of a “healing divinity,” contextualizing the worship within its broader religious milieu can better capture its full complexity. By extension, the research paves the way for reconsidering the conventional classification that assigns relatively fixed symbolic values to Buddhist deities, which contributes to a more thorough and nuanced understanding of religious practices and beliefs.
Aesthetic Judgment: A Pragmatic View
Authors: Serpell C. Namwali
Published: May 2024

Abstract: This essay stages a critique of Michael W. Clune’s A Defense of Judgment , raising problems with its theoretical assumptions, interpretive methods, and literary readings. At the same time, the essay offers a counterproposal for a theory of judgment premised on incommensurability, meaning attuned to the contingency of aesthetic values, to the context of their perception, and to their uses for different purposes. The anticapitalism of this pragmatic (and pragmatist) view derives from neither a presumed equality of artworks nor from a hierarchy that ranks them, but rather from a radical embrace of the sociality and incommensurability of art—particularly in the classroom.
The African American Collections Relating to Music at Emory University’s Rose Library
Authors: Shirts Peter
Published: May 2024

ABSTRACT: United States music history has for years privileged whiteness and largely ignored or disregarded the contributions of African Americans. The Stuart R. Rose Manuscript, Archives, and Rare Book Library at Emory University in Atlanta, Georgia, houses over thirty collections (and growing) related to African American musicians that could be used to both uncover and recover the critical role African Americans played in the music culture of the United States. This article presents a brief overview of these holdings to date, including the papers of composers (such as William Dawson, George Walker, and Undine Smith Moore), entertainers (such as Victoria Spivey, Bricktop, and Geoffrey Holder), and researchers (such as Rae Linda Brown, Geneva Southall, and Delilah Jackson). Types of materials held include manuscript letters and scores, photographs, and published music (both print and recorded) by and about African Americans.
DHM/SERS reveals cellular morphology and molecular changes during iPSCs-derived activation of astrocytes
Authors: Bu Xiaoya , Yang Liwei , Han Xianxin , Liu Shengde , Lu Xiaoxu , Wan Jianhui , Zhang Xiao , Tang Ping , Zhang Weina , Zhong Liyun
Published: May 2024

The activation of astrocytes derived from induced pluripotent stem cells (iPSCs) is of great significance in neuroscience research, and it is crucial to obtain both cellular morphology and biomolecular information non-destructively in situ, which is still complicated by the traditional optical microscopy and biochemical methods such as immunofluorescence and western blot. In this study, we combined digital holographic microscopy (DHM) and surface-enhanced Raman scattering (SERS) to investigate the activation characteristics of iPSCs-derived astrocytes. It was found that the projected area of activated astrocytes decreased by 67%, while the cell dry mass increased by 23%, and the cells changed from a flat polygonal shape to an elongated star-shaped morphology. SERS analysis further revealed an increase in the intensities of protein spectral peaks (phenylalanine 1001 cm-1, proline 1043 cm-1, etc.) and lipid-related peaks (phosphatidylserine 524 cm-1, triglycerides 1264 cm-1, etc.) decreased in intensity. Principal component analysis-linear discriminant analysis (PCA-LDA) modeling based on spectral data distinguished resting and reactive astrocytes with a high accuracy of 96.5%. The increase in dry mass correlated with the increase in protein content, while the decrease in projected area indicated the adjustment of lipid composition and cell membrane remodeling. Importantly, the results not only reveal the cellular morphology and molecular changes during iPSCs-derived astrocytes activation but also reflect their mapping relationship, thereby providing new insights into diagnosing and treating neurodegenerative diseases.
Patient informed consent, ethical and legal considerations in the context of digital vulnerability with smart, cardiac implantable electronic devices
Authors: Torgersen Leanne N. S. , Schulz Stefan M. , Lugo Ricardo G. , Sütterlin Stefan
Published: May 2024

Advancements in digitalisation with cardiac implantable electronic devices (CIEDs) allow patients opportunities for improved autonomy, quality of life, and a potential increase in life expectancy. However, with the digital and functional practicalities of CIEDs, there exists also cyber safety issues with transferring wireless information. If a digital network were to be hacked, a CIED patient could experience both the loss of sensitive data and the loss of functional control of the CIED due to an unwelcome party. Moreover, if a CIED patient were to become victim of a cyber attack, which resulted in a serious or lethal event, and if this information were to become public, the trust in healthcare would be impacted and legal consequences could result. A cyber attack therefore poses not only a direct threat to the patient’s health but also the confidentiality, integrity, and availability of the CIED, and these cyber threats could be considered “patient-targeted threats.” Informed consent is a key component of ethical care, legally concordant practice, and promoting patient-as-partner therapeutic relationships [1]. To date, there are no standardised guidelines for listing cybersecurity risks within the informed consent or for discussing them during the consent process. Providers are responsible for adhering to the ethical principles of autonomy, beneficence, non-maleficence, and justice, both in medical practice generally and the informed consent process specifically. At present, the decision to include cybersecurity risks is mainly left to the provider’s discretion, who may also have limited cyber risk information. Without effective and in-depth communication about all possible cybersecurity risks during the consent process, CIED patients can be left unaware of the privacy and physical risks they possess by carrying such a device. Therefore, cyber risk factors should be covered within the patients’ informed consent and reviewed on an ongoing basis as new risk information becomes available. By including cyber risk information in the informed consent process, patients are given the autonomy to make the best-informed decision.
Transcriptomic and proteomic analysis of the virulence inducing effect of ciprofloxacin on enterohemorrhagic Escherichia coli
Authors: Kijewski Anne Cecilie Riihonen , Witsø Ingun Lund , Sundaram Arvind Y. M. , Brynildsrud Ola Brønstad , Pettersen Kristin , Anonsen Eirik Byrkjeflot , Anonsen Jan Haug , Aspholm Marina Elisabeth
Published: May 2024

Enterohemorrhagic E. coli (EHEC) is considered to be the most dangerous pathotype of E. coli, as it causes severe conditions such as hemorrhagic colitis (HC) and hemolytic uremic syndrome (HUS). Antibiotic treatment of EHEC infections is generally not recommended since it may promote the production of the Shiga toxin (Stx) and lead to worsened symptoms. This study explores how exposure to the fluoroquinolone ciprofloxacin reorganizes the transcriptome and proteome of EHEC O157:H7 strain EDL933, with special emphasis on virulence-associated factors. As expected, exposure to ciprofloxacin caused an extensive upregulation of SOS-response- and Stx-phage proteins, including Stx. A range of other virulence-associated factors were also upregulated, including many genes encoded by the LEE-pathogenicity island, the enterohemolysin gene (ehxA), as well as several genes and proteins involved in LPS production. However, a large proportion of the genes and proteins (17 and 8%, respectively) whose expression was upregulated upon ciprofloxacin exposure (17 and 8%, respectively) are not functionally assigned. This indicates a knowledge gap in our understanding of mechanisms involved in EHECs response to antibiotic-induced stress. Altogether, the results contribute to better understanding of how exposure to ciprofloxacin influences the virulome of EHEC and generates a knowledge base for further studies on how EHEC responds to antibiotic-induced stress. A deeper understanding on how EHEC responds to antibiotics will facilitate development of novel and safer treatments for EHEC infections.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications
Authors: Tettey Rebecca , Egyir Beverly , Tettey Prudence , Arko-Mensah John , Addo Samuel Ofori , Owusu-Nyantakyi Christian , Boateng William , Fobil Julius
Published: May 2024

Wastewater discharge into the environment in resource-poor countries poses a threat to public health. Studies in this area within these countries are limited, and the use of high-throughput whole-genome sequencing technologies is lacking. Therefore, understanding of environmental impacts is inadequate. The present study investigated the antibiotic resistance profiles and diversity of beta-lactamases in Escherichia coli strains isolated from environmental water sources in Accra, Ghana. Microbiological analyses were conducted on wastewater samples from three hospitals, a sewage and wastewater treatment plant, and water samples from two urban surface water bodies. Confirmed isolates (N = 57) were selected for phenotypic antibiotic resistance profiles. Multi-drug-resistant isolates (n = 25) were genome sequenced using Illumina MiSeq sequencing technology and screened for sequence types, antibiotic resistance, virulence and beta-lactamase genes, and mobile genetic elements. Isolates were frequently resistant to ampicillin (63%), meropenem (47%), azithromycin (46%), and sulfamethoxazole-trimethoprim (42%). Twenty different sequence types (STs) were identified, including clinically relevant ones such as ST167 and ST21. Five isolates were assigned to novel STs: ST14531 (n = 2), ST14536, ST14537, and ST14538. The isolates belonged to phylogroups A (52%), B1 (44%), and B2 (4%) and carried β-lactamase (TEM-1B, TEM-1C, CTX-M-15, and blaDHA-1) and carbapenemase (OXA-1, OXA-181) resistance genes. Dominant plasmid replicons included Col440I (10.2%) and IncFIB (AP001918) (6.8%). Polluted urban environments in Accra are reservoirs for antibiotic-resistant bacteria, posing a substantial public health risk. The findings underscore the need for targeted public health interventions to mitigate the spread of antibiotic-resistant bacteria and protect public health.
The coupling coordination relationship between sports industry agglomeration and economic resilience in the Yangtze River Delta region
Authors: Ma Hongyu , Li Lingli
Published: May 2024

With a rapidly growing sports industry worldwide, one may argue that sports industry agglomeration can play a crucial role in the economy of the sports industry. In particularly, the coupling linkage between sports industry agglomeration and economic resilience can be leveraged to promote both economic quality and efficiency. Based on data on three provinces and one city in the Yangtze River Delta region during the 2011–2020 period, this study uses the entropy-weighted TOPSIS method, coupling coordination degree model, and relative development models to explore the coupling coordination relationship between sports industry agglomeration and economic resilience in this region. The results show that: (1) Sports industry agglomeration shows an overall increasing albeit fluctuating trend with inter-provincial differences. (2) Economic resilience has steadily increased, while the economic resilience kernel density curve generally shows a "dual peaks" trend. (3) The coupling coordination between sports industry agglomeration and economic resilience remains in a fluctuating, albeit coordinated state. These findings are relevant for the integration and high-quality development of the sports industry in the Yangtze River Delta region.
Acute toxicity appraisal of Saussurea heteromalla extract and development of its chemotherapeutic herbal dosage form
Authors: Batool Azra , Muddassir Muhammad , Alshammari Basmah H. , Alsahli Tariq G. , Solre Gideon F. B. , Liu Yanting , Khan Muhammad Tariq , Malik Nadia Shamshad , Ahsan Hina , Khan Muhammad Tahir , Malik Muhammad Nasir Hayat , Miana Ghulam Abbas
Published: May 2024

Ethnopharmacological relevance of Saussurea species for anti-cancer compounds instigated us to develop chemotherapeutic herbal tablets. This study was an ongoing part of our previous research based on the scientific evaluation of Saussurea heteromalla (S. heteromalla) for anti-cancer lead compounds. In the current study, S. heteromalla herbal tablets (500 /800 mg) were designed and evaluated for anti-cancer activity. Arctigenin was found as a bioactive lead molecule with anti-cancer potential for cervical cancer. The in vitro results on the HeLa cell line supported the ethnopharmacological relevance and traditional utilization of S. heteromalla and provided the scientific basis for the management of cervical cancer as proclaimed by traditional practitioners in China. LD50 of the crude extract was established trough oral acute toxicity profiling in mice, wherein the minimum lethal dose was noticed as higher than 1000 mg/kg body weight orally. Chromatographic fingerprint analysis ensured the identity and consistency of S. heteromalla in herbal tablets in terms of standardization of the herbal drug. About 99.15% of the drug (S. heteromalla crude extract) was recovered in herbal tablets (RSD: 0.45%). In vitro drug release profile was found to be more than 87% within 1 h, which was also correlated with different mathematical kinetic models of drug release (r2 = 0.992), indicating that drug release from matrix tablets into the blood is constant throughout the delivery. The dosage form was found stable after an accelerated stability parameters study which may be used for anti-cervical cancer therapy in the future, if it qualifies successful preclinical investigation parameters.
A time-varying analysis between economic uncertainty and tourism development in Singapore
Authors: Ngoc Bui Hoang , Hoang Canh Chi , Tram Nguyen Huynh Mai
Published: May 2024

Tourism development (TO) is seen as a viable solution to address economic policy uncertainty (EPU) risks. However, previous studies have largely ignored the relationship between short, medium, and long term by decomposing TO and EPU index at different time-frequency scales, especially in Singapore. In this study, the Wavelet tools analysis and a rolling window algorithm are employed to re-visit the causal relationship between EPU, industrial production index (IPI), government revenue (GR), and tourism development (TO) in Singapore from January 2003 to February 2022. The findings revealed the heterogeneous effects of EPU on TO at different time horizons in terms of importance and magnitude over time. A rise in EPU results in a decline in TO at the low frequencies, indicating that EPU has a detrimental effect on TO over the short term. Conversely, in the long term, an increase in TO results in a decrease in EPU. Furthermore, the outcome also indicated that there is a uni-directional causality running from TO to EPU, GR and IPI. Expressly, we confirm that the negative co-movement is more pronounced in the aftermath of the COVID-19 crisis, particularly for EPU, and GR at low-medium frequencies throughout the research period. The findings provide tourism policymakers with insight to develop strategic plans for tourism development that consider the effects of economic policy uncertainty. By understanding how uncertainty impacts tourism, governments can tailor development strategies to mitigate risks and capitalize on opportunities.