bluuebunny/crossref_metadata_2025 huggingface dataset:
Método didáctico de estudio de casos y su efecto en el rendimiento académico del estudiantado de un instituto peruano de educación superior
Authors: Trujillano Rojas Roberto Carlos , Vargas Merino Jorge Alberto
Published: August 2024

Motivar al estudiantado en la educación superior es un gran desafío. Utilizar métodos como el estudio de caso debería permitir conectar teoría y práctica en aula, influyendo en el aprendizaje y el rendimiento académico. La finalidad de esta investigación fue determinar si la aplicación del método didáctico estudio de caso tiene un efecto en el rendimiento académico del alumnado de un Instituto Privado de Lima en Perú. La metodología siguió un enfoque cuantitativo, de diseño cuasiexperimental, que incluyó observación, aplicación de casos y encuestas en el grupo experimental para verificar si el estudio de caso genera efecto en el rendimiento académico, ello en una muestra final de 25 personas del alumnado del primer ciclo. Al utilizar la Prueba t de Student y U mann de Whitney en las notas de entrada y salida, los valores obtenidos revelan una significancia bilateral superior a 0.05, lo que implica que no hay diferencias significativas entre los grupos por el método de estudio de caso. Se concluyó que la aplicación del método estudio de caso no genera efecto en el rendimiento académico del estudiantado del curso de Gestión de Sistema de Transporte de la carrera de Administración Logística de un Instituto Privado de Educación Superior. Se recomienda a otras personas investigadoras que continúen explorando el tema y avancen en la teoría para alcanzar mejoras en la enseñanza superior. Se sugiere investigar distintos modelos y aplicaciones del estudio de caso en centros educativos para comprender sus efectos en el rendimiento académico y en otras variables relacionadas, a nivel nacional e internacional.
Toward qualitative growth: Exaptations, graphene and Industry 4.0
Authors: Kovács Olivér
Published: August 2024

This contribution aims to address the intriguing issue of whether Industry 4.0, as a techno-economic paradigm shifter, may have a greater potential for exaptation (i.e., using it not for pursuing of quantitative but that of qualitative development) and, if so, what technologies may accelerate this process. Existing research indicates that graphene technology has the potential to lead the way in this area. The paper addresses not only why and how a graphene-aided Industry 4.0 can be conducive to this function (i.e., making exaptations easier on a larger scale), it examines the wider context for exaptations by questioning whether the current setup of the real economy, the financial universe, and the public sector offers a supportive environment for exaptations.
AI-based automatic identification and processing techniques for agricultural safety information
Authors: Li Aiping , Wang Pei , Shao Lin , Liu Huiyun
Published: August 2024

In the context of globalization, agricultural safety is directly linked to food security and human health. Modern agriculture’s challenge is effectively monitoring and processing vast agricultural safety information in the digital era. This study aims to achieve the automatic identification and intelligent processing of agricultural safety information within a digital media environment by applying artificial intelligence (AI) technologies. Initially, the background of AI applications in agriculture is explored, followed by an analysis of the urgent need for automated processing of agricultural safety information and an overview of current research in this field. It is demonstrated that, despite progress, existing methods still lack in-depth feature extraction and real-time capabilities of the data processing systems. A method based on multi-level feature fusion for identifying agricultural product safety is proposed to address these limitations alongside a decentralized AI Internet of Things (IoT) system for processing agricultural safety information. The multi-level feature fusion method can extract and integrate essential details on agricultural products from different dimensions and levels, thus enhancing the identification accuracy. Meanwhile, the decentralized AIoT system strengthens the efficiency and reliability of data processing, ensuring timely responses to agricultural safety information. Through deep neural networks, efficient recognition and classification of agricultural product images were achieved, enabling the automatic identification of agricultural safety information in a digital media environment. Utilizing deep learning algorithms, the system could learn and understand the characteristics of different agricultural products and accurately identify potential safety issues, such as pests, diseases, or spoilage, providing timely monitoring and management for agricultural production. The innovation of this research lies in the comprehensive utilization of multi-level data features and advanced Internet of Things (IoT) technology, significantly improving the level of intelligence in agricultural safety supervision.
Ecclesiastical refuge in medieval Wales: formation and role in political processes
Authors: Gusakova A. V.
Published: August 2024

The article is devoted to the penetration of the concept of ecclesiastical refuge into the British Isles, its spread and regional peculiarities. The focus is on the origin and realization of the right of ecclesiastical refuge in the territory of the Welsh kingdoms from the early Middle Ages, when sources record the first signs of the allocation of the temple territory as a place with a special legal status, until the XV century, when the charters of the English kings approved the traditional privilege of Welsh religious centers to provide security to those in need. Being one of the most important achievements of church diplomacy, the right of ecclesiastical refuge was directly related to the status of a religious center: documents confirming it were preserved and copied, if there were no documents, they were forged or episodes in which they hid someone from persecution within the walls of their cell or monastery were included in the lives of the patron saints. The almost simultaneous appearance of such plots in the Lives of the late XI–XII centuries. It suggests that this was one of the main arguments of the Welsh religious communities in the struggle to maintain their position in the face of the changes that began with the arrival of the Normans on the island. For representatives of the secular authorities, the right of ecclesiastical refuge was an inconspicuous but very effective political tool that allowed, on the one hand, to control local religious communities, allowing them to exercise the privilege they needed or violating it, on the other hand, creating an opportunity at the right moment to ensure the safety of both themselves and other participants in political processes.
A. A. Smirnov and the Christian point in Old Irish narrative tradition: a case of "nativism" in Early Russian Celtic Studies?
Authors: Bogdanova A. A.
Published: August 2024

The article is devoted to the concepts contributed by Alexander Smirnov about the Irish Church and the role of Christian culture to the Old Irish narrative tradition in general. Archival records shows that so-called "Christian element" was entirely accepted by him and was emphasized in an initially neutral formula; later, however, passages about the ‘undoubted Christian influence’ related to some motifs were replaced by such markers as "late interpolations" or "artificial insertions". The turn from a comprehensive approach to an intensive search for the archaic "Celtic basis" has affected all aspects of Smirnov’s discourse: from the interpretation of particular motifs to the characteristics of Christianization and Irish Church organization in general. Due to these observations, we suppose to depict such Smirnov’s conceptions as the truly ‘nativist’ position.

The author gives special gratitude to the National Library of Russia, the Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences for an opportunity to work and consult with their founds and record series.
Results and Discussion. The dinosaurs and the problem of editorial format
Authors: Sánchez-Reyes Ayixon
Published: August 2024

In this essay I explore the difficulties faced by scientific authors in the editorial format currently in use, drawing parallels with historical and cultural references. Focusing particularly on the song "Los Dinosaurios" by Charly García, I discuss the impact of the editorial requirement to separate - or unite - the Results and Discussion sections in scientific articles. I argue individually that this separation is often arbitrary and unproductive, using historical examples of notable scientific publications to illustrate the benefits of a unified approach. The ultimate goal of this essay is to advocate for a more streamlined and less restrictive editorial process that fosters creativity and efficiency in scientific communication
ENERGY EFFICIENT SECURITY PROTOCOL FOR HEALTHCARE INTERNET OF THINGS
Authors: Babu Ravi Mahesh , Malluvalasa S.N. Lakshmi , Devi M. Kalpana , Karthik Sagirala Satya , Rakesh M. , Prasad Satamraju Krishna
Published: August 2024

The Energy Efficient Security for Internet of Things (EESP-IoT) protocol aims to achieve a harmonious equilibrium between energy preservation, security, and network optimization within the ever-changing domain of the internet of things (IoT). EESP-IoT coordinates the actions of IoT
devices where each device independently optimizes its energy usage throughout the network to ensure stability and equity. Adaptive techniques such as power optimization, alternating between sleep and wake modes, and energy harvesting reduce energy inefficiency, while assuring security
by using lightweight specifically designed cryptographic techniques. By including energy and security considerations, the protocol achieves both efficiency and resilience against a range of security threats. EESP-IoT exhibited exceptional energy conservation skills, while maintaining
comparable levels of throughput and latency. The protocol underwent testing in a simulated environment to assess its ability to handle a large number of devices and its effectiveness in various network circumstances. The findings confirmed that EESP-IoT is capable of maintaining a high
degree of network efficiency and strong security procedures, while considerably prolonging the lifespan of IoT devices.
Safety impacts of design for manufacturing and assembly techniques in off-site construction
Authors: Simukonda Wakisa , Emuze Fidelis
Published: August 2024

Design for manufacturing and assembly (DfMA) is an approach for improving project safety performance. For off-site construction (OSC), the philosophy is increasingly becoming a preferred design approach for OSC components. However, studies examining the safety impact of DfMA in OSC are limited. This study investigated the potential effects of DfMA techniques on mitigating specific safety hazards in OSC. A literature review identified and paired DfMA techniques and the safety hazards that they mitigate. Empirical data were collected using a survey to assess the identified relationships. Data were analysed using a combination of frequencies, inferential statistics and Cronbach’s alpha. Most respondents agreed that DfMA techniques control their pairwise safety hazards in OSC. To eliminate safety hazards and limit their socio-economic impact, contracting organisations engaged in OSC need to consider the application of DfMA in the manufacturing, assembly and disassembly processes of OSC. The study reaffirms the importance of implementing evidence-based DfMA techniques for mitigating safety hazards in developing countries where OSC is an emerging philosophy.
PROPRIOCEPÇÃO NAS ENTORSES DE TORNOZELO DE ATLETAS DO VOLEIBOL FEMININO
Authors: TEODORO NADIA , VALANSUELO ESTEFFANY , ACUNHA BARBOSA VIVIANE
Published: August 2024

O voleibol é um dos esportes mais populares do mundo e está em ascensão no cenário brasileiro. Para tal crescimento as exigências físicas, técnicas e psicológicas, obrigam os jogadores a trabalharem perto dos seus limites, e como consequência, maior predisposição a lesões. Lesões causadas por instabilidade do tornozelo serão o foco principal deste estudo. Para avaliação foi utilizado antes e após o Star Excursion Balance Test (SEBT) e Hop Test em 6 atletas profissionais da equipe adulta de voleibol feminino, com idade entre 20 e 30 anos, da cidade de Foz do Iguaçu – PR. Esta pesquisa tem como objetivo analisar os efeitos de protocolos proprioceptivos nas entorses de tornozelo em atletas femininas de voleibol e explorar a eficácia dos protocolos realizados, tanto no solo quanto na água.
Ação Imunomoduladora da Estimulação Parassimpática promovida pelo Exercício Físico
Authors: Gomes de Mello Priscila
Published: August 2024

Introduction: Physical exercise promotes the stimulation of the vagal nerve and different neural networks, contributing to a more effective anti-inflammatory response in order to contribute to cardiovascular, metabolic and immunological benefits. Objective: To associate the role of physical exercise with parasympathetic stimulation and its possible implications in immunomodulation Methods: This is a qualitative, explanatory and descriptive study on the immunomodulatory action of parasympathetic activation through physical exercise through a bibliographic review. The databases used were: PubMed, Scopus, Scielo and Web of Science involving all original articles from January 2015 and June 2024. Results: The main findings are related to differences in physical exercise intensity, which can contribute to the modulation of the innate immune system and the expression of neutrophil and lymphocyte cell populations, which can contribute to a more specific immune response. Aerobic training and strength training had similar responses in reducing BMI and glycated hemoglobin, reducing sympathetic tone, increasing parasympathetic tone, and improving the sympatho/vagal balance for controlling heart rate variability. There was a negative association between vagal neuroimmunomodulation (NIM) and mortality, since the lower the NIM index, the shorter the survival time in the population sample. Conclusion: Aerobic physical exercise and strength training can contribute to the activation of the parasympathetic system and immune system and provide better adjustments in the innate and adaptive immune response dependent on the intensity and volume of training.
The effect of vanadium on the magnetic and mechanical properties of B2 FeCo alloy: a DFT approach
Authors: Ledwaba T.M. , Diale R.G. , Ngoepe P.E. , Chauke H.R.
Published: August 2024

FeCo alloys play an important role in soft magnetic materials with a wide range of technological applications due to their high saturation magnetization and Curie temperature. However, these alloys have low ductility at room temperature. The ductility can be improved by the ternary addition of elements such as V. A density functional theory supercell approach was used to generate B2 Fe50Co50-xVx (0 < x < 50) structures and the properties were evaluated at different atomic percentage compositions to determine the ductility at room temperature. The structures were fully optimized to obtain better equilibrium ground-state properties such as lattice parameters and thermodynamic properties for both binary and ternary systems. The stability of Fe50Co50-xVx was evaluated from the heats of formation, elastic properties, and phonon dispersion curves. Furthermore, magnetic strength was evaluated from magnetic moments. It was found that all structures are thermodynamically stable due to the negative heats of formation. The calculated Pugh's ratio and Poisson's ratio confirm that alloying with V effectively improved the ductility. It was also found that Fe50Co50-xVx showed a positive shear modulus for the entire concentration range investigated, in agreement with phonon dispersion curves. The ternary addition of V to the FeCo system resulted in reduced magnetic strength due to a decrease in magnetic moments. These findings reveal that B2 FeCo-V alloys can be used as components and actuators for the automotive industry.
Quantifying uncertainty in rock mass properties: Implications for GSI, RMi, and RMR assessments
Authors: Abbas N. , Li K.G. , Emad M.Z. , Khan A.
Published: August 2024

Probability-based empirical methods were employed as an alternative approach to predicting uncertainties associated with rock mass properties. The focus was on developing probabilistic spreadsheets to forecast rock mass classification indexes. Histograms were constructed to describe the best distribution in predicting rock mass properties. The developed models also offer utility in predicting the impact of discontinuities within the rock mass on rock strength and rock mass classification systems. Statistical analyses identified volumetric joint count, joint spacing, joint frequency, and rock strength as the most influential parameters. Moreover, the statistical analysis revealed varying degrees of correlation among different rock mass properties. While some properties demonstrated significant correlations suitable for modelling, others did not align well with any correlation model. The results highlight the need for a comprehensive approach to rock mass characterization, considering multiple factors beyond volumetric joint count. Geological complexities, including tectonic activity and weathering processes, may obscure direct correlations. These results emphasize the importance of empirical modelling and detailed site investigations for accurate assessment of rock mass quality and stability in the Himalaya.
Взаимосвязь концепта выражения и теории знаков у Делёза
Authors: Поздняков Борис Борисович
Published: August 2024

В рамках предлагаемой статьи изложены два концепта — концепт выражения и концепт теории знаков, с опорой на Жиля Делёза и его понимание Спинозы. Концепт выражения подразумевает наличие сразу двух типов выражения, прямого и косвенного, на пересечении которых находится одно «особое исключение» — человек, выпадающий из общего порядка выражения. В сознании человека два типа выражения противоречат друг другу. Косвенное выражение дано человеку в виде смутных знаков, которые склоняют человека к одному из двух решений: либо полностью встроиться в порядок прямого выражения, тем самым сведя свою жизнь к чистой актуальности (и стать подобным всякой другой вещи), либо сделать ставку на свое особенное человеческое существование, полное знаков, без попытки их дешифровывать/познавать/разрешать. Кроме этого, в статье будет предложена систематизация всех возможных знаков, употребляемых Делёзом на протяжении его творчества, в виде пяти инвариантов, встречающихся в соответствующих текстах: индикативные, любовные, абстрагирующие, императивные, а также особенные знаки — события. Автор утверждает, что несмотря на то, что иногда Делёз называет события — знаками, а некие знаки — событиями, мы можем их различить с точки зрения их смысла. Знаки ведут человека к актуальному существованию, путем уничтожения всякого образца и умножения бесконечных симулякров, в то время как события подразумевают утверждение несовозможных миров, постоянно подстраивающихся под актуальную действительность в прошлом и будущем. Область знаков и событий одна и та же — это косвенное выражение от других вещей в нашем сознании, которые предстают перед нами в виде проблемы, задачи, вопроса и так далее; однако смысл этого выражения (какое бы не было его актуальное место) различен, а поэтому само разделение между знаком и событием оказывается скорее функциональным, нежели онтологическим.
Искусство знаков
Authors: Дальгарно Джордж , Рахманкулов Эмиль Булатович , Осминская Наталия Александровна , Янин Владимир Александрович , Онегин Илья Сергеевич , Идрисова Рената Динаровна
Published: August 2024

Перевод: Dalgarno G. Ars Signorum vulgo Character Universalis et Lingua Philisophica [1661] // The Works of George Dalgarno of Aberdeen. — Edinburgh : T. Constable, 1834. — P. 11–82.
Индийская философия в межкультурной перспективе
Authors: Лысенко Виктория Георгиевна
Published: August 2024

В статье представлена концепция индийской философии, которая подводит итог индологическим исследованиям автора за последние сорок пять лет. Статья состоит из введения, четырех частей и заключения. Во введении формулируется тезис о семейном сходстве индийской и западной мыслительных традиций, основанном на их происхождении от общего индоевропейского языкового субстрата. В первой части артикулируются лингвистические возможности философского мышления, которые предоставляет санскрит — язык индийских философских текстов, и которые он разделяет с индоевропейскими языками западных национальных традиций философствования. В рамках этих общих возможностей выделены те, которые преимущественно реализовала именно индийская традиция: грамматика, лингвофилософия, учения о небытии и о причинно-следственных связях и др., и те, в разработке которых индийская традиция пришла к результатам, принципиально отличающим ее от западной (например, когнитивное значение измененных состояний сознания, инструментальность человеческого состояния, а не его самоценность в сотериологической перспективе и др.). Во второй части рассматриваются герменевтико-культурные причины неприятия индийской традиции в качестве философской со стороны западных (и отечественных) философов, главная из которых — присутствие в ней сотериологической, духовно-практической перспективы «от первого лица», а также разъясняется необходимость демаркации концепта философии от концептов мудрости и гнозиса. В третьей части анализируются категории самоописания индийской традиции (шравана, манана, бхавана, или запоминание на слух, рациональное осмысливание, личностная ассимиляция через практику медитации), а также цивилизационные и культурные явления, которые сформировали ее теоретическое и философское наследие (звукоцентризм, ритуалистика, диспутальная традиция и психопрактики). В четвертой части выделяются важнейшие черты историко-философского процесса в Индии. В заключении сформулированы основные цивилизационно-культурные особенности индийской философской мысли в сравнении с мировоззренческими принципами западной традиции, а также идеи, представляющие эвристический интерес для развития философской проблематики на Западе и в России.
Anlagenpass der Zukunft
Authors: Bleistein Thomas , Becker Robert , Barton Luisa , Wilhelm Annika , Werth Dirk
Published: August 2024

In diesem Artikel wird die automatische Erstellung eines digitalen Anlagenpasses für den Anlagen- und  Maschinenbau erörtert, der vor dem Hintergrund zunehmender Nachhaltigkeitsanforderungen entstanden ist. Die automatisierte Erstellung des Passes durch systematische Datenerfassung und den Einsatz von Künstlicher Intelligenz wird dabei konzipiert. Ziel der Integration dieses Passes ist es, die Effizienz in der Berichterstattung zu steigern und den steigenden  Nachhaltigkeitsanforderungen gerecht zu werden. Zudem werden die Herausforderungen und Potenziale, die mit der Implementierung verbunden sind, analysiert, um die Industrie in den Themen wie Nachhaltigkeit zu  unterstützen.
Prática avançada em enfermagem, Liderança e Implementação de melhorias para reduzir infecções relacionadas à assistência à saúde
Authors: Flores Paula Vanessa Peclat
Published: August 2024

Objetivo: Relatar a experiência dos enfermeiros na liderança de um projeto de Implementação de melhorias para reduzir Infecções relacionadas à assistência de saúde em uma Unidade de Terapia Intensiva. Método: Relato de experiência sobre a execução por enfermeiros de um projeto de melhoria na perspectiva das práticas avançadas de enfermagem da Unidade de Terapia Intensiva (UTI), de um hospital universitário do estado do Rio de Janeiro no período de agosto de 2021 a outubro de 2023. Resultados: Houve a seleção de profissionais para compor a equipe de melhoria, a enfermeira coordenadora de enfermagem ficou responsável pela liderança e execução do projeto. Liderar projetos de melhoria exige do enfermeiro competências e habilidades para o alcance de resultados positivos. Conclusão: A liderança do enfermeiro faz parte do escopo da prática avançada de enfermagem no ambiente de terapia intensiva, colaborando para modificação de indicadores assistenciais.
Exploring the Effects of Societal Cynicism on Social Media Dependency
Authors:   University ", Za Stefano ,   G. d'Annunzio",   of Chieti-Pescara, IT, Ceci Federica ,   University “G. d’Annunzio” of Chieti-Pescara, IT, Masciarelli Francesca ,   University “G. d’Annunzio” of Chieti-Pescara, IT, Iaia Lea ,   University of Turin, IT, Scornavacca Eusebio ,   Arizona State University, Tempe, USA
Published: August 2024

The Social Media landscape is characterized by constant and rapid changes, with new platforms emerging in the market and existing ones evolving by integrating new features. Amidst this dynamic environment, the phenomenon of Social Media Dependency (SMD) has become particularly salient. This study seeks to explore individual usage behavior on Social Media with a specific focus on SMD. In contrast to previous research that predominantly examines Social Media addiction, our emphasis lies on the utilitarian, rational, and goal-oriented aspects of Social Media usage. We analyze the impact of individual attitudes on SMD by integrating expectancy-value theory with media system dependency theory. Specifically, this paper investigates how one particular social axiom construct – Societal cynicism – influences SMD, taking into account the variations in the usage patterns between two widely used Social Media platforms: Facebook and YouTube. Through the development and validation of a research model, this research aims to shed new light on understanding the dependency phenomena within the context of Social Media.
Metabolic disorders and androgen deficiency in the pathogenesis of urolithiasis
Authors: Emirgaev Zaur K. , Tagirov Ruslan N. , Tagirov Nair S. , Vasiliev Andrei G. , Tagirov Ruslan N.
Published: August 2024

This review summarizes and critically analyzes current data on the pathogenesis of urolithiasis (urolithiasis, nephrolithiasis). Emphasis is placed on such issues as: mechanisms of urinary stone formation; risk factors for stone formation; the role of oxidative stress; the chemical composition of renal stones (and especially oxalates); the role of Randall’s plaques, osteopontin, uromodulin (Tamm–Horsfall protein), α-enolase; and the mechanism of stone formation in the collecting ducts. Insufficiently studied issues of microbiota influence — (a) kidney and urinary tract and (b) gastrointestinal tract are also considered. Attention is paid to new approaches to understanding the pathogenesis and treatment of urolithiasis, namely works on genetics, epigenetics, genetic engineering and proteomics. The imperfection of existing animal models of urolithiasis is shown. The issue of application of androgen replacement therapy in the treatment of patients suffering from urolithiasis is considered separately. The author considers the main theoretical result of his work to be the approval of the idea of urolithiasis as a systemic disease, in which any significant deviation of the internal environment constants violates the delicate balance that ensures the solubility of substances in primary urine and their excretion with secondary urine. The practical result is to confirm the applicability of androgen replacement therapy in the treatment of patients suffering from urolithiasis.
Possibilities of Azilsartan Medoxomil for Preparation for Planned Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus
Authors: Kochergina A. M. , Barbarash O. L.
Published: August 2024

Aim. To evaluate the efficacy and safety of azilsartan medoxomil for preoperative preparation and improving the long-term prognosis of elective percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD), arterial hypertension (AH), and type 2 diabetes mellitus (DM).

Material and methods. The study sample included patients with type 2 DM referred for elective PCI who had poor blood pressure (BP) control according to 24-hour BP monitoring (24-BPM) (mean daily systolic BP ≥130 mmHg, mean daily diastolic BP ≥80 mmHg). The data were collected from 2018 through 2020. A total of 75 patients was included and distributed by simple randomization into two groups: group 1 (main, n=37) received azilsartan medoxomil as an antihypertensive drug at a dose of 40 mg/day (previously prescribed angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers (ARB) were discontinued); group 2 (control, n=38) continued on their previous antihypertensive therapy. The follow-up period was 6 months. During each of 5 consecutive follow-up visits, the patient was examined, 24-BPM was recorded, and urinary markers of renal dysfunction (glomerular filtration rate, GFR; neutrophil gelatinase-associated lipocalin, NGAL; urine albumin-creatinine ratio, UACR; kidney injury molecule, KIM-1; and interleukin-18, IL-18) were measured.

Results. During the azilsartan treatment, GFR decreased by 7.4%, while in the control group, it decreased by 18.9% (p<0.001). For 6 months of follow-up, no changes in the NGAL concentration were found in the main group, while the NGAL concentration in the control group increased by 12.9%. With azilsartan, there was a decrease in the urinary concentration of IL-18 (16.9%), while in patients of the control group, IL-18 increased (7.14%). Proteinuria progressed in both groups, which was expectable given the presence of DM; however, in patients receiving azilsartan, the UACR value increased by 37.5%, while in patients of the control group, it increased by 96.15%. These differences were statistically significant. No statistically significant differences were found in the concentrations of cystatin C and KIM-1.

Conclusion. This study demonstrated two important facts: the possibility for diagnosing contrast-induced acute kidney injury (CI-AKI) using new, more sensitive markers of kidney damage, which is important for assessing the effectiveness of prevention, and the possibility of using ARBs, in particular azilsartan, for the prevention of CI-AKI in patients with IHD in combination with AH and DM.
A Case of Successful Treatment of Severe Hyperlipidemia After Heart Transplantation With Inclisiran
Authors: Tatarintseva Z. G. , Tkhatl L. K. , Barbuhatti K. O. , Kosmacheva E. D.
Published: August 2024

The prognosis after heart transplantation continues to improve. Therefore, the prevention of chronic post-transplant sequelae, such as chronic kidney disease, allograft vasculopathy, and malignancies is becoming increasingly important. Everolimus, an inhibitor of the mammalian target of rapamycin (mTOR), is increasingly used for immunosuppression after heart transplantation. However, everolimus may cause a characteristic complex of adverse effects, including dyslipidemia. Currently there are no guidelines for the long-term screening and treatment of dyslipidemia in heart transplant recipients treated with everolimus. This article presents a clinical case of hypercholesterolemia that developed after the start of the everolimus treatment in a heart recipient. The patient was a 39-year-old man who underwent orthotopic heart transplantation for ischemic cardiomyopathy in 2012 (at the age of 27). In 2019, the patient’s immunosuppressive therapy was converted from mycophenolate mofetil to everolimus due to the development of cardiac allograft vasculopathy. The change in the immunosuppressive therapy was associated with increases in total cholesterol and low-density lipoprotein cholesterol, which were not reversed with a combined lipid-lowering therapy (maximum doses of rosuvastatin, ezetimibe, fenofibrate). A decrease in lipid levels was achieved with a blocker of hepatic proprotein convertase subtilisin/kexin type 9 synthesis at the level of microribonucleic acid (inclisiran). This case demonstrates the difficulties in correcting dyslipidemia in patients with cardiac allograft, since the treatment with the immunosuppressant everolimus worsens existing dyslipidemia. However, the combination lipid-lowering therapy, that affects various elements of the pathogenesis (specifically, the combined inhibition of hydroxymethylglutaryl-CoA reductase with a statin, cholesterol absorption from the small intestine with ezetimibe, and PCSK9 messenger RNA with inclisiran), provides an effective control of blood lipids and minimizing the adverse effects of immunosuppressive therapy, such as cardiac allograft vasculopathy.
CIMA Brief #26: Gender and Learning: Understanding Skill Gaps in Primary Education
Authors: Näslund-Hadley Emma , Alonzo Haydée
Published: August 2024

The gender-based achievement gap in mathematics tends to widen in favor of boys as students advance through their educational journey, evidenced by comparing data from 3rd and 6th grade in primary education. Conversely, the gender achievement gap favoring girls in language typically decreases between 3rd and 6th grade in most countries. While gender significantly explains the achievement gaps in mathematics, it does not consistently account for gaps in language and science.
LA AVIFAUNA DE LA VERTIENTE ORIENTAL DE LOS ANDES DE COLOMBIA. TRES EVALUACIONES EN ELEVACIÓN SUBTROPICAL
Authors: Bohórquez Clara Isabel
Published: August 2024

Se presentan los resultados de tres inventarios ornitológicos realizados entre 950 y 2200 m de elevación en la vertiente oriental de la cordillera Oriental de Colombia. La avifauna fue registrada principalmente por medio de observaciones y captura con redes. Realicé un análisis según las características ecológicas de las aves, con relación al uso de los diferentes hábitats para identificar los grupos de especies más sensibles a las perturbaciones. En total fueron registradas 321 especies, con una mayor riqueza en Los Picachos, siendo Thraupinae el grupo más abundante. Los valores de riqueza representaron en promedio el 60% del total estimado, siendo evidente la necesidad de las grabaciones de cantos para inventarios de aves. Los Picachos es el área con mayor proporción de especies sensibles a las perturbaciones y amenazadas de extinción, con una alta presión de colonización a pesar de existir allí un Parque Nacional. La información aquí presentada es una de las primeras sobre la avifauna de esta región en Colombia.
ANALYSIS OF KPK (CORRUPTION ERADICTION COMMISSION) POSITION AFTER THE CONSTITUTIONAL COURT DECISION NUMBER 70/PUU-XVII/2019 FROM THE PERSPECTIVE OF THE NEW SEPARATION OF POWERS
Authors: Shafira Gita Amara Sandy
Published: August 2024

In 2019 Law Number 19 of 2019 concerning the Second Amendment to Law Number 30 of 2002 concerning the Corruption Eradication Commission was passed. The second amendment to the KPK Law has changed the position and structure of the KPK institution quite a lot. In the same year, a review of Law Number 19 of 2019 was proposed in the Decision of the Constitutional Court Number 70/PUU-XVII/2019. This study will focus on analyzing the position of the KPK after the issuance of the Constitutional Court Decision Number 70/PUU-XVII/2019 by using the theory of The New Separation Of Power. This research is a normative legal research (legal research) that uses two approaches, namely the statutory approach and conceptual approach  which in this case uses the Constitutional Court Decision Number 70/PUU-XVII/2019 and the theory The New Separation of Powers. The results of this study indicate that the Court decided that the state institution KPK is part of the executive power clump on the grounds that the KPK carries out executive functions in the executive domain. On the other hand, The New Separation Of Powers theory sees KPK as having to be included outside of the three main branches of power which in The New Separation Of Powers theory is referred to as a "new branch of power" or "fourth branch of power" because the KPK carries out its mixed functions and also because the KPK fulfills the characteristics of an independent state institution.
KRITIKAL ANALISIS PENEGAKAN HUKUM TERHADAP TINDAK PIDANA CYBER PORNOGRAPHY: KAJIAN PERBANDINGAN HUKUM NEGARA INDONESIA DAN CHINA
Authors: Eko Nurisman  , Emiliya Febriyani  , Suwandi
Published: August 2024

The rise of cyber pornography is a crucial problem that attacks the morals of the young generation in various countries. Every country in the world has different regulations in handling cyber pornography crime as a form of prevention. Indonesia until now still has difficulties in suppressing the high crime of cyber pornography, therefore good regulation and law enforcement are needed to suppress the high cyber pornography. Reflecting on China which has proven and succeeded in suppressing the high crime of cyber pornography. By using the legislative approach and comparative approach, this research proves that by conducting a comparative study of law with other countries, namely China, it can be an alternative to national law reform, especially in dealing with the rise of cyber pornography in Indonesia.
SECURITIES CROWDFUNDING: KAJIAN REGULASI PASAR MODAL DI INDONESIA
Authors: Mutiara Yusian , Wishnu Kurniawan, S.H., M.H.  , Nikmah Mentari, S.H., M.H.
Published: August 2024

The concept of crowdfunding based on securities offerings allows micro, small and medium enterprises to obtain funds and capital through securities crowdfunding. However, investors in this case have a great risk of loss because issuers who issue securities through securities crowdfunding are not companies like issuers in the Stock Exchange. This causes many of them to be very new, so they may not have good management. This research aims to see how the law can protect securities crowdfunding investors. This research uses a juridical-normative approach to see the legal protection of securities crowdfunding investors in Law No. 4 of 2023 concerning Strengthening and Development of the Financial Sector and the Financial Services Authority Regulation (POJK). The results of this study indicate that Law No. 4 of 2023 concerning Development and Strengthening of the Financial Sector and Financial Services Authority Regulation (POJK) No. 16/POJK.04/2021 have provided legal protection to securities crowdfunding investors, namely preventive protection and repressive protection. However, regarding the protection of the parties, it is still hampered by several factors, such as investor ignorance, unpreparedness of human resources, and slow handling of complaints by the organizers. In addition, the prospectus issued by the issuer often cannot be confirmed for accuracy, due to differences in information disclosure standards such as securities offerings on the Stock Exchange and the absence of involvement of professional institutions.
Herbal Medicine: A Potential Therapeutic Approach for Breast Cancer in Near Future
Authors:   Department of Rasashastra and Bhaishajya Kalpana, Ayurveda Mahavidhyalaya, Hubli, Karnataka, India, Hugar Veerappa , Kanashetti Daneshwari S , Dwevedi Nayan Kamal
Published: August 2024

The use of naturally occurring compounds to stop carcinogenesis is expanding. It has been shown that a variety of herbal extracts and pure active compounds produced exclusively from plants have potent anti-cancer properties. Herbs can play a supportive role in promoting complete recovery, alleviating side effects, and addressing cancer-related issues. Haridra- Curcuma longa, Guduchi- Tinospora cordifolia, Atasi- Linum ussitatissimum, Kalajaji- Nigella sativa, Lashuna- Allium sativum, Ashwagandha- Withania somnifera, Kalamegha- Andrographis paniculata, Trapusha- Podophyllum hexandrum, Shigru- Moringa ptyrygosperma,Bhumyalaki- Phyllanthus niruri, Pippali- Piper longum etc. are various plants having scientific evidence of anticancer property.Numerous in vitro and in vivo studies have suggested that these medications have potential for treating breast cancer. Studies focused on molecular pathways have aided in the discovery of the main therapeutic strategies for treating breast cancer. The focus of future research should be on patient-centered translational trials for breast cancer. These will strengthen the therapeutic effectiveness of our Ayurvedic medication. This review seeks to offer experimental support and a greater understanding of the molecular processes by which various herbs function as chemotherapeutic agents against distinct forms of breast cancer. Keywords Anti-cancer, Ayurvedic herbs, Plant based medicine, Breast cancer
Prognostic Factors Related to Sleep Quality in Patients With Obstructive Sleep Apnea After Positive Airway Pressure Therapy
Authors: Park Dong Heun , Choi Hangseok , Nam Kukjin , Lee Seung Hoon , Seo Min Young
Published: August 2024

Background and Objectives: This study aimed to evaluate the factors that influence deep sleep restoration in patients with obstructive sleep apnea (OSA) following positive airway pressure (PAP) therapy.Methods: In total, 363 patients diagnosed with OSA who received PAP therapy over at least 3 months were enrolled in the study. Polysomnographic parameters, anatomical characteristics, and subjective sleep-related parameters were evaluated according to the presence of daytime sleepiness and morning headache before and after 3 months of PAP treatment.Results: Age was significantly different according to whether excessive daytime sleepiness (EDS) was alleviated (average: 49.35 years) or persisted (average: 52.82 years) (p=0.001). Age was also significantly associated with morning headache (p=0.037). Body mass index (BMI) was higher in the alleviated EDS group (28.70 kg/m2) than in the persistent EDS group (27.13 kg/m2; p=0.002). The apnea-hypopnea index (AHI) was correlated with the EDS outcome (p=0.011). The group with alleviated EDS had a longer mandibular plane to hyoid distance (MPH) than the group with persistent EDS (17.95 mm vs. 15.38 mm; p<0.001). However, BMI, AHI, and MPH showed no significant associations with morning headache. Epworth Sleepiness Scale scores were higher in the alleviated EDS and alleviated morning headache groups (EDS: p<0.001, morning headache: p=0.001). Self-Efficacy Measure for Sleep Apnea (SEMSA) values differed significantly between the EDS groups (p<0.001), but not between the morning headache groups (p=0.122). After 3 months of PAP therapy, the MPH was negatively correlated with EDS in univariate (odds ratio [OR]=0.921, p<0.001) and multivariate analyses (OR=0.937, p=0.028). The SEMSA score was also negatively correlated with EDS in univariate (OR=0.961, p<0.001) and multivariate (OR=0.973, p=0.019) analyses.Conclusion: Age, polysomnographic metrics, and anatomical considerations were important for sleep quality-associated daytime symptoms. In addition, anatomical characteristics and the patient’s self-efficacy were significantly associated with the effect of PAP treatment on sleep quality.
Comparative Analysis of the Clinical Manifestations of Sinonasal Natural Killer T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma
Authors: Shin Chol Ho , Aloraimi Muna , Kim Tae Gyeong , Yu Myeong Sang
Published: August 2024

Background and Objectives: Natural killer T-cell lymphoma (NKTCL) and diffuse large B-cell lymphoma (DLBCL) are the two most prevalent subtypes of lymphoma in the sinonasal region. Accurately differentiating between sinonasal DLBCL and NKTCL is crucial for determining the appropriate treatment and prognosis. The present study compared the clinical characteristics of these two conditions.Methods: We conducted a retrospective review of 173 patients diagnosed with sinonasal lymphoma at a single institute between 2004 and 2017. This review included only patients with DLBCL and NKTCL who had more than 6 months of follow-up records. We analyzed patient data encompassing clinical characteristics, pathologic findings, radiologic findings, treatment modalities, recurrence, and survival.Results: Among the patients analyzed, 117 patients were diagnosed with NKTCL and 45 with DLBCL. Endoscopic evaluation revealed a significantly higher incidence of crusting (p<0.001) and necrotic lesions (p=0.001) in patients with NKTCL, whereas polypoid masses were more commonly observed in patients with DLBCL (p<0.001). Computed tomography (CT) scans indicated no significant differences in bilaterality or bone destruction between the two groups. The DLBCL group exhibited a higher rate of concurrent lymph node or organ involvement than the NKTCL group (p<0.001). The 5-year overall survival rate was 67.4% for DLBCL and 69.1% for NKTCL, with no significant difference between the two.Conclusion: Clinical differences exist between sinonasal DLBCL and NKTCL in terms of endoscopic and CT findings. These distinct characteristics can aid in distinguishing between the two types of sinonasal lymphoma during clinical diagnosis.
Birth outcomes in pregnant women with gestational diabetes mellitus
Authors: Zabolotneva Ksenia O. , Zharkin Nikolay A.
Published: August 2024

From the perspective of modern obstetrics, gestational diabetes mellitus (GDM) is considered an epidemic of the 21st century. It can complicate the course of pregnancy at any week of gestation. The purpose of the work was to determine the influence of the gestational age of GDM onset on birth outcomes in pregnant women. Materials and methods: During the study, a retrospective analysis of 362 individual records of pregnant and postpartum women was carried out. Results: Earlier onset of GDM is significantly more often associated with the development of symphysitis in the mother, with fetal growth retardation and the need to use insulin therapy to correct hyperglycemia. Conclusions: Regardless of the period of onset of GDM, pregnant women constitute a risk group for obstetric and perinatal complications.
Modern strategies of hemotransfusiology and alternatives to blood transfusion
Authors: Holbreich Vyacheslav A. , Maskin Sergey S. , Matyukhin Viktor V. , Klimovich Igor N. , Alexandrov Vasily V.
Published: August 2024

The review analyzes studies on the use of various blood transfusion strategies. In clinical practice, there is a clear trend towards the use of a restrictive transfusion strategy. A minority of studies have shown the benefits of liberal tactics of blood transfusions. In most articles, it is noted that the decision on the issue of blood transfusion should be based on a comprehensive assessment of the patient’s condition. The development of new blood-saving technologies will improve the quality of surgical care and increase safety for the patient.
The severity of pelvic pain syndrome associated with external genital endometriosis in women of reproductive age as a prognostic factor for the degree of prevalence of the process
Authors: Grigoryants Armen A. , Burova Natalia A. , Avrutskaya Valeria V. , Krukier Irina I. , Aksenenko Denis V. , Kilpa Yuri V.
Published: August 2024

The severity of pain in patients with external genital endometriosis (EGE) associated with pelvic pain syndrome was assessed using a visual analogue scale (VAS) and the McGill pain questionnaire, and the effectiveness of surgical treatment of patients with EGE was assessed. Predicting the IV and I degrees of endometriosis prevalence will allow the obstetrician-gynecologist to choose treatment tactics for patients, diagnose and the ability to prevent the progression of the disease in the early stages.