bluuebunny/crossref_metadata_2025 huggingface dataset:
Rewiring of the N-Glycome with Prostate Cancer Progression and Therapy Resistance
Authors: Butler William , McDowell Colin , He Yiping , Yang Qing , Hauck Spencer , Zhou Yinglu , Armstrong Andrew , George Daniel , Drake Richard , Huang Jiaoti
Published: July 2022

An understanding of the molecular features associated with prostate cancer progression (PCa) and resistance to hormonal therapy is crucial for the identification of new targets that can be utilized to treat advanced disease and prolong patient survival. Many studies have investigated changes to the levels of various biomolecules such as RNA, protein, and small molecule metabolites. The glycome, which encompasses all sugar polymers (glycans) synthesized by cells, has remained relatively unexplored in the context of advanced PCa despite the fact that glycans have great potential value as biomarkers and therapeutic targets due to their high density on the cell surface. Using imaging mass spectrometry (IMS), we profiled the N-linked glycans in tumor tissue derived from 131 patients representing the entire spectrum of PCa to identify glycosylation changes associated with loss of tumor cell differentiation, disease remission, therapy resistance and disease recurrence, as well as neuroendocrine (NE) differentiation which is a major mechanism for therapy failure. Our results indicate significant changes to the glycosylation patterns in various stages of PCa, notably a decrease in tri- and tetraantennary glycans correlating with disease remission, a subsequent increase in these structures with the transition to therapy-resistant PCa, and downregulation of complex N-glycans correlating with NE differentiation. Furthermore, both nonglucosylated and monoglucosylated mannose 9 demonstrate aberrant upregulation in therapy-resistant PCa which may be useful therapeutic targets as these structures are not normally presented in healthy tissue. Our findings, for the first time, characterize changes to the tumor glycome throughout the entire evolution of PCa, identifying several glycan markers and signatures which may be useful for diagnostic or therapeutic purposes.
Leveraging Image Complexity in Macro-Level Neural Network Design for Medical Image Segmentation
Authors: Khan Tariq M. , Naqvi Syed S. , Meijering Erik
Published: July 2022

Recent progress in encoder-decoder neural network architecture design has led to significant performance improvements in a wide range of medical image segmentation tasks. However, state-of-the-art networks for a given task may be too computationally demanding to run on affordable hardware, and thus users often resort to practical workarounds by modifying various macro-level design aspects. Two common examples are downsampling of the input images and reducing the network depth or size to meet computer memory constraints. In this paper, we investigate the effects of these changes on segmentation performance and show that image complexity can be used as a guideline in choosing what is best for a given dataset. We consider four statistical measures to quantify image complexity and evaluate their suitability on ten different public datasets. For the purpose of our illustrative experiments, we use DeepLabV3+ (deep large-size), M2U-Net (deep lightweight), U-Net (shallow large-size), and U-Net Lite (shallow lightweight). Our results suggest that median frequency is the best complexity measure when deciding on an acceptable input down-sampling factor and using a deep versus shallow, large-size versus lightweight network. For high-complexity datasets, a lightweight network running on the original images may yield better segmentation results than a large-size network running on downsampled images, whereas the opposite may be the case for low-complexity images.
Barriers and facilitators to naloxone uptake in Ohio: implications for community-driven overdose reduction interventions
Authors: Estadt Angela T. , Lancaster Kathryn E. , Sanchez Sabrina D. , Ricks JaNelle
Published: July 2022

Background
Naloxone is a life-saving and easy-to-administer opioid antagonist medicine. Despite naloxone's legality in Ohio, unintentional drug overdoses remain the leading cause of injury deaths. Understanding the barriers and facilitators to naloxone's community uptake will help inform interventions to increase the awareness, accessibility, and use of naloxone. Our study aimed to identify barriers and facilitators to opioid overdose reversal uptake to inform community-driven interventions.
Methods
We conducted in-depth interviews and focus group discussions with people who use opioids, community members, and key stakeholders in Central Ohio from February 2019 to October 2019. We used qualitative thematic analysis to identify barriers and facilitators to the uptake of naloxone in a community setting. We classified barriers and facilitators to community naloxone uptake using the socio-ecological model's exterior levels – organizational, community, and societal.
Results
A total of 47 Central Ohio residents participated in five focus group discussions and fifteen in-depth interviews. Community members (n = 23), harm reduction service providers (n = 4), and religious organizational staff (n = 5) participated in focus group discussions ranging in size from 4 to 10 participants. We conducted in-depth interviews with law enforcement officers (n = 3), pharmacists (n = 2), and people who use opioids (n = 10). At the organizational level, access to naloxone, lack of resources, organizational stigma, and misinformation emerged as barriers. In contrast, naloxone awareness and availability, safe spaces for people who use opioids, and organizational collaboration emerged as facilitators. We identified the following community-level barriers: naloxone misinformation, knowledge, awareness, and substance use stigma. Perspectives on collective responsibility to administer naloxone was identified as both a barrier and facilitator. At the societal level, despite Ohio's Good Samaritan law and the legality of naloxone, poor communication of naloxone laws was a prevalent barrier to naloxone uptake, as was the burden of law enforcement to respond to and manage overdoses.
Conclusions
Community-based interventions that develop collaborations among local organizations to provide naloxone information, training, and distribution may address prominent barriers to naloxone uptake and reduce the current burden of law enforcement to respond to overdoses. Future interventions should also dispel naloxone misinformation, substance-use stigma, and confusion about the legal consequences of administering naloxone.
FRIBAS database for better characterization of RC and URM buildings: Towards specific T-H relationships
Authors: Gallipoli Maria Rosaria , Gallipoli Maria Rosaria , Petrovic Bojana , Calamita Giuseppe , Tragni Nicola , Scaini Chiara , Barnaba Carla , Vona Marco , Parolai Stefano
Published: July 2022

FRIBAS database is an open access database (https://doi.org/10.5281/zenodo.6505442) made up of the characteristics of 313 buildings (71 masonry, 238 reinforced concrete and 4 mixed types). It collects and harmonizes data from different surveys performed on buildings in the Basilicata and Friuli Venezia Giulia regions (Southern and North-eastern Italy, respectively). Each building is defined by 37 parameters related to the building and foundation soil characteristics. Building and soil fundamental periods were estimated experimentally based on ambient noise measurements. FRIBAS gave us the opportunity to study the influence of the main characteristics of buildings to their structural response and soil-building interaction effect. In this study, we have used FRIBAS dataset to investigate how the building period varies as a function of building typologies and soil conditions. Our results motivate the need of going beyond a ‘one-fits-all’ numerical period-height (T-H) relationship for generic building typologies provided by seismic code, towards a specific characterization of T-H relationships that account for both soil and building typologies.
NAP1L5 targeting combined with MYH9 Inhibit HCC progression through PI3K/AKT/mTOR signaling pathway
Authors: Zhao Rui , Ge Yuzhen , Gong Yongjun , Li Bo , Xiao Benli , Zuo Shi
Published: July 2022

Purpose:Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide. Nucleosome assembly protein 1-like 5 (NAP1L5) is a protein-coding gene that encodes a protein similar to nucleosome assembly protein 1 (NAP1). It is a histone chaperone that plays an important role in gene transcription in organisms. However, the role of NAP1L5 in the pathogenesis of hepatocellular carcinoma remains to be elucidated.Method：We used QRT-PCR, immunohistochemistry and westernbolting to detect the expression of NAP1L5 in tissues and cell lines, and analyzed the relationship between its expression and clinicopathological features and prognosis. after up-regulating and down-regulating NAP1L5 in cell lines, we used a variety of methods to verify its regulatory effect on HCC, and verified it again in animal experiments, mass spectrometry analysis to find the possible binding protein (MYH9) and downstream signaling pathway (PI3K/AK/mTOR). And verify the relationship between them.Results: In this study, low expression of NAP1L5 was found in hepatocellular carcinoma, and the downregulation of NAP1L5 was related to shorter survival and disease-free survival. In addition, its expression is also related to the tumor size and recurrence of hepatocellular carcinoma. The overexpression and knockdown of NAP1L5 by plasmid and siRNA showed that NAP1L5 inhibited the proliferation, migration and invasion and induced apoptosis of hepatoma cells. In vivo experiments confirmed that NAP1L5 can inhibit the growth and metastasis of hepatocellular carcinoma cells. In the mechanistic study, we found that NAP1L5 affects the occurrence and development of hepatocellular carcinoma by regulating MYH9 to inhibit the PI3K/AKT/mTOR signaling pathway. Conclusion: As a functional tumor suppressor, NAP1L5 is expressed at low levels in HCC. NAP1L5 inhibits the PI3K/AKT/mTOR signaling pathway in hepatocellular carcinoma by regulating MYH9.It may be a new potential target for liver cancer treatment.
Anti-inflammatory and anti-oxidant activities of Gymnema sylvestre extract rescues acute respiratory distress syndrome in rats via modulating the NF-κB/MAPK pathway
Authors: JANGAM ARUNA , TIRUNAVALLI SATYA KRISHNA , ADIMOOLAM BALA MANIKANTHA , KASIREDDY BHAVANA , PATNAIK SAMATA SAI , Erukkambattu Jayashankar , Thota Jagadeshwar Reddy , Andugulapati Sai Balaji , ADDLAGATTA ANTHONY
Published: July 2022

Acute respiratory distress syndrome (ARDS) is one of the major cause of mortality in COVID-19 patients, due to limited therapeutic options. This prompted us to explore natural sources to mitigate this condition. Gymnema sylvestre (GS) is an ancient medicinal plant known to have various therapeutic effects. In this investigation, Gymnema sylvestre hydroalcoholic extract (HAEGS) was examined against lipopolysaccharide (LPS) induced lung injury and ARDS in in vitro and in vivo models. UHPLC-HRMS/GC-MS was employed for characterizing the HAEGS and identified several active derivatives including gymnemic acid, gymnemasaponins, gymnemoside, gymnemasin, quercetin, and long fatty acids. Gene expression by RTqPCR and DCFDA analysis by flow-cytometry revealed that several inflammatory cytokine/chemokine, cell injury markers, and reactive-oxygen-species (ROS) levels were highly upregulated in LPS control and were significantly reduced upon HAEGS treatment. Consistent with the in vitro studies, we found that in LPS induced ARDS model, pre-treatment with HAEGS significantly suppressed the LPS-induced elevation of inflammatory cell infiltrations, cytokine/chemokine marker expression, ROS levels, and lung injury in a dose dependent manner. Further mechanistic studies suggested that the HAEGS ameliorates the ARDS through the NF-κB/MAPK signaling pathway. Additional fractionation results revealed that fraction-6 which has the exclusive composition of gymnemic acid derivatives showed anti-inflammatory effects which is similar to the HAEGS. Overall, HAEGS significantly mitigated the LPS-induced lung injury and ARDS by targeting NF-κB/MAPK signaling pathway. Thus, our work unravels the protective role of HAEGS for the first time in managing ARDS.
Change in quality of life and psychological distress in patients with resected non-metastatic vs unresectable advanced cancer undergoing systemic treatment
Authors: Rodríguez-Gonzalez Adán , Carmona-Bayonas Alberto , Hernandez Raquel , Cruz-Castellanos Patricia , Velasco-Durantez Verónica , Antoñanzas-Basa Mónica , Lorente-Estelles David , Corral María J , González-Moya Manuel , Castillo-Trujillo Alfredo , Jimenez-Fonseca Paula , Esteban Emilio , Calderon Caterina
Published: July 2022

Purpose: Cancer and its treatments changes patients’ quality of life. The aim was to analyze quality of life, psychological distress, and life satisfaction in patients with resected versus unresectable cancer.Methods: Two prospective, multicenter (15 medical oncology departments), studies with consecutive patient recluitment were conducted, NEOetic, in individuals with unresectable advanced disease (2020-2021) and NEOcoping, in subjects with resected non-metastatic cancer (2016-2018). Participants completed quality of life (EORTC QLQ-C30), emotional distress (Brief Symptom Inventory, BSI), and life satisfaction (Satisfaction with Life Scale, SWLS) questionnaires before systemic antineoplastic treatment and after treatment. A descriptive, bivariate chi-square analysis and t-tests were performed to ascertain the differences between localized and advanced cancer.Results: A total of 1450 patients were recruited, 941 (65%) with a resected cancer and 509 with unresectable advanced cancer with a mean age of 59.0 and 64.9 years, respectively. The most common cancers were colorectal (42%) and breast (34%) in resected group and bronchopulmonary (29%), colorectal (17%), and pancreatic (11%) in unresectable advanced cancer group. Subjects with advanced disease exhibited worse scores on functional scales (physical, cognitive, emotional, and social), and had more symptoms than those with resected disease prior to initiating systemic treatment. Individuals with advanced cancer displayed better functional status and fewer symptoms, but more fatigue and nausea and those with resected cancer presented worse physical and cognitive function, more psychological distress, and more symptoms post-treatment. Conclusion: This sample reveals how antineoplastic treatment can enhance quality of life for people with unresectable advanced disease and negatively affect individuals with resected, non-metastatic cancer.Structured Abstract: Our study shows the potential quality of life benefit of systemic antineoplastic treatment in patients with unresectable advanced cancer. In addition, it shows the deterioration of quality of life in patients with resected non-metastatic cancer after completion of adjuvant treatment.
Representational momentum of biological motion in full-body, point-light and single-dot displays
Authors: Zucchini Elena , Casile Antonino
Published: July 2022

Observing the actions of others triggers, in our brain, an internal and automatic simulation of its unfolding in time. Here, we investigated whether the instantaneous internal representation of an observed action is modulated by the point of view under which an action is observed and the stimulus type. To this end, we motion captured the elliptical arm movement of a human actor and used these trajectories to animate a photorealistic avatar, a point-light stimulus or a single dot rendered either from an egocentric or an allocentric point of view. Crucially, the underlying physical characteristics of the movement were the same in all conditions. In a representational momentum (RM) paradigm, we then asked subjects to report the perceived last position of an observed movement at the moment in which the stimulus was randomly stopped. In all conditions subjects tended to misremember the last configuration of the observed stimulus as being further forward than the veridical last showed position. This misrepresentation was however significantly smaller for full-body stimuli compared to point-light and single dot displays and it was not modulated by the point of view. We interpret these findings as evidence that full-body stimuli elicit a simulation process that is closer to the instantaneous veridical configuration of the observed movements while impoverished displays (both point-light and single-dot) elicit a prediction that is further forward in time. For all stimulus types, this simulation process seems to be independent from the point of view under which the actions are observed.
A nomogram for predicting postoperative overall survival of patients with lung squamous cell carcinoma: a SEER-based study
Authors: Rao Jin , Yu Yue , Zhang Li , Wang Pei , Wang Xuefu , Wang Zhinong
Published: July 2022

Background: Lung squamous cell carcinoma (LSCC) is a common subtype of non-small cell lung cancer. Our study aimed to construct and validate a nomogram for predicting overall survival (OS) for postoperative LSCC patients. Methods: A total of 8,078 patients eligible for recruitment between 2010 and 2015 were selected from the Surveillance, Epidemiology and End Results database. The study outcomes were 1-, 2-, and 3-year OS. Analyses performed included univariable and multivariable Cox regression, receiver the operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA), and Kaplan-Meier survival curves.Results: Seven variables were selected to establish the nomogram for LSCC. The area under the curve in ROC curve revealed 0.658, 0.651, and 0.647 in the training cohort and 0.673, 0.667, and 0.658 in the validation cohort at 1-, 2-, and 3-year survival. The calibration curves showed satisfactory consistencies between nomogram-predicted and observed survival probability. DCA showed great clinical net benefit. In risk stratification systems, patients were divided into three risk groups with a significant difference in OS in Kaplan-Meier curves (P＜0.001).Conclusions: A prognostic nomogram for OS of postoperative LSCC patients was developed and validated, which may assist clinicians in evaluating prognosis and providing highly individualized therapy.
The effect of the Interactive Self-talk and Mental Imagery program on Badminton Motor Skills and Self-Confident of Youth Beginner Student- Athletes
Authors: Hidayat Yusuf , Yudiana Yunyun , Hambali Burhan , Sultoni Kuston , Ustun Umit Dogan , Singhnoy Chatkamon
Published: July 2022

Background: self-talk (ST) and mental imagery (MI) psychological strategies have an essential role in training and sports performance, but their implementation is still limited, especially when they are implemented in combination use. This study aimed to examine badminton motor skills (BMS) and self-confidence (SC) mastery after the ST and MI psychological strategy intervention, both in independent and interactive functions integrated into the BMS training process. Methods: Eighty badminton beginner student-athletes aged years 11.4+52 years old (Male=40, Female=40) were divided through a disproportional stratified sampling into four experimental groups (EG: 2-function ST x 2-function MI) and one control group (CG). The intervention program was eight weeks (24 meetings and three times a week). Participants completed a fidelity check at each session. At the end of the intervention, they took a BMS test and completed a self-confidence scale. Results: ST and MI strategies had a significant effect on the BMS and SC mastery (independent and interaction functions), in multivariate and univariate ways, except that, independently, they had no significant effect on SC. The effect of I-ST > M-ST and the effect of C-MI > M-MI on BMS, but there was no different effect on SC. In the M-MI function, the effect of I-ST > M-ST on the BMS and SC mastery. Meanwhile, in the C-MI function, I-ST and M-ST did not have a different interaction effect on BMS and the effect of M-ST > I -ST on SC in the C-MI function. In the M-ST function, the effect of C-MI > M-MI on BMS and SC, but there was no difference of the interaction effect on BMS in the I-ST condition. Ethics approval: Centre of Research and Community Service, Universitas Pendidikan Indonesia (Project No. B-1030/UN40.PL/PJ.00.00/2021), approval date: 25 June 2021.Conclusion: The results of this study strengthen the evidence on the effectiveness of ST and MI strategies in motor skill mastery and psychological skill development of beginner student-athletes. Thus, ST and MI strategies can be adapted as psychological strategies that coaches and physical educators can use to improve beginner student-athlete's learning, sports performance, and psychological skills.
Primary septic arthritis of the knee caused by Neisseria meningitidis serogroup B in an elderly patient. Case report and review of the literature
Authors: Longo Benedetta , Fazio Cecilia , Meini Simone , Neri Arianna , Andreoli Elisabetta , Vacca Paola , Salamone Domenico , Sani Spartaco , Mura Maddalena , Bracalente Irene , Venturini Luigi , Andreini Roberto , Ambrosio Luigina , Carannante Anna , Stefanelli Paola
Published: July 2022

Purpose: Primary meningococcal arthritis (PMA) represents an uncommon clinical presentation of meningococcal infection, mainly reported among young people. Herein, a case of PMA of the knee in an elderly patient is described.Case presentation: On January 2022, an 87-year-old patient arrived at hospital with continuous fever persisting for three days and a picture of joint pain, swelling, redness, and warmth of her left knee. An arthrocentesis was promptly performed and the inoculated synovial fluid turned positive with numerous Gram-negative diplococci at the microscopic examination. The BioFire® FilmArray®Meningitis/Encephalitis (ME) Panel (bioMérieux) quickly confirmed the presence of Neisseria meningitidis. The meningococcal isolate belonged to the serogroup B (MenB), Sequence type (ST)-162/ clonal complex (cc)162. Two grams of ceftriaxone twice a day were administered for 21 days; than cefditoren pivoxil 400 mg twice a day for further 6 weeks after discharge. In Italy, from 2018 to January 2022, among 135 MenB, 31 MenB/cc162 were identified, of which only the case here reported was associated with an atypical clinical picture.Review of the literature: A total of 40 cases of PMA caused by N. meningitidis was reported in the literature, but only 4 occurred in elderly. To our knowledgements, no cases of PMA caused by MenB were previously reported among patients of more than 65 years of age.
A Novel Compartmental Approach to Modeling COVID-19 Disease Dynamics and Analyzing the Effect of Common Preventative Measures
Authors: Lin Caden
Published: July 2022

As of December 2020, the COVID-19 pandemic has infected over 75 million people, making it the deadliest pandemic in modern history. This study develops a novel compartmental epidemiological model specific to the SARS-CoV-2 virus and analyzes the effect of common preventative measures such as testing, quarantine, social distancing, and vaccination. By accounting for the most prevalent interventions that have been enacted to minimize the spread of the virus, the model establishes a paramount foundation for future mathematical modeling of COVID-19 and other modern pandemics. Specifically, the model expands on the classic SIR model and introduces separate compartments for individuals who are in the incubation period, asymptomatic, tested-positive, quarantined, vaccinated, or deceased. It also accounts for variable infection, testing, and death rates. I first analyze the outbreak in Santa Clara County, California, and later generalize the findings. The results show that---although all preventative measures reduce the spread of COVID-19---quarantine and social distancing mandates reduce the infection rate and subsequently are the most effective policies, followed by vaccine distribution and, finally, public testing. Thus, governments should concentrate resources on enforcing quarantine and social distancing policies. In addition, I find mathematical proof that the relatively high asymptomatic rate and long incubation period are driving factors of COVID-19’s rapid spread.
Paving the way for synthetic C1- metabolism in Pseudomonas putida through the reductive glycine pathway
Authors: Bruinsma Lyon , Wenk Sebastian , Claassens Nico , Santos Vitor Martins dos
Published: July 2022

One-carbon (C1) compounds such as methanol, formate, and CO2 are alternative, sustainable microbial feedstocks for the biobased production of chemicals and fuels. In this study, we engineered the carbon metabolism of the industrially important bacterium Pseudomonas putida to assimilate these three substrates through the reductive glycine pathway. First, we demonstrated the functionality of the C1-assimilation module by coupling the growth of auxotrophic strains to formate assimilation. Next, we extended the module from formate to methanol using both NAD and PQQ – dependent methanol dehydrogenases. Finally, we demonstrated CO2-dependent growth through CO2 reduction to formate by the native formate dehydrogenase, which required short-term evolution to rebalance the cellular NADH/NAD+ ratio. This research paves the way to engineer P. putida towards growth on formate, methanol, and CO2 as sole feedstocks, thereby substantially expanding its potential as a sustainable and versatile cell factory.
Psychological resilience mediates the association between childhood maltreatmentand self-harm phenotype in Chinese early adolescents
Authors: Li Yuan , Li Yong-Han , He Yang , Chen Shan-Shan , Chang Jun-Jie , Yuan Meng-Yuan , Cao Lei-Lei , Wang Shao-Jie , Wang Geng-Fu , Su Pu-Yu
Published: July 2022

BackgroundSelf-harm (SH) increases significantly in early adolescence with great variability, and childhood maltreatment (CM) contributes to this increase. Understanding the developmental pathway from CM to SH could provide clues for SH prevention. This study used latent class analysis (LCA) to detect the phenotype of SH and explored the role of psychological resilience in the pathway from the CM to SH phenotype.MethodsA cross-sectional study was conducted with 5724 early adolescents from three middle schools in Anhui Province, China. We categorized SH into five subtypes based on their severity and further explored SH phenotypes by LCA to detect the heterogeneity of SH. Moreover, a path model was performed to test the mediation of resilience in the CM-SH association.ResultsThe prevalence rates of highly lethal SH, less lethal SH with visible tissue damage, SH without visible tissue damage, self-harmful behaviours with latency damage and psychological SH were 10.2%, 25.8%, 35.5%, 20.8% and 28.2%, respectively. Three interpretable phenotypes of SH were identified: low SH (57.8%), medium SH (29.0%), and high SH (13.2%). Furthermore, CM was positively associated with the SH phenotype, psychological resilience mediated the association between CM and the SH phenotype (all ps < 0.01), and a larger mediating effect was observed in the medium SH (22.41%).ConclusionsOur findings offer new perspectives that improving psychological resilience can be used as an efficient intervention to reduce the risk of SH among early adolescents who have experienced CM.
BMI and pelvimetry help to predict the duration of laparoscopic resection for low and middle rectal cancer
Authors: Teng Wenhao , Liu Jingfu , Chen Meimei , Zang Weidong , Wu Aiwen
Published: July 2022

Background: In rectal cancer surgery, recent studies have found associations between clinical factors, especially pelvic parameters, and surgical difficulty; however, their findings are unreliable because the studies use different criteria. This study aims to evaluate common clinical factors that influence operative time for the laparoscopic anterior resection of low and middle rectal cancer.Methods: Patients who underwent laparoscopic radical resection of low and middle rectal cancer from January 2018 to December 2020 were retrospectively analyzed and classified according to operative time. Preoperative clinical and MRI-related parameters were collected. Logistic regression analysis was used to identify factors for predicting operative time.Results: In total, 214 patients with a mean age of 60.3±8.9 years were divided into two groups: the long operative time group (n=105) and the short operative time group (n=109). Univariate analysis revealed that male sex, higher BMI(≥24.0 kg/m2), preoperative treatment, smaller pelvic inlet (<11.0 cm), and shorter pelvic depth(<10.7 cm) were significantly correlated with longer operative time(P<0.05). However, only BMI(OR=1.893,95% CI 1.064-3.367, P=0.030) and pelvic inlet (OR=0.439,95% CI 0.240-0.804, P=0.008) were independent predictors of longer operative time. Moreover, the rate of anastomotic leakage was higher in the group with a longer operative time (P<0.05).Conclusion: A longer surgical duration might be associated with more anastomotic leakage; however, surgical duration was predictable when considering BMI and pelvic inlet. Laparoscopic rectal resection patients with higher BMI or smaller pelvic inlets are expected to take longer to perform. This finding is helpful for centers that lack surgical resources; by taking it into consideration, these centers can make more reasonable surgical arrangements and prepare for exceptional postoperative management.
The benefit of treatment beyond progression with immune checkpoint inhibitors: A multi- center study
Authors: Guven Deniz Can , Yekeduz Emre , Erul Enes , Yazgan Sati Coskun , Sahin Taha Koray , Karatas Gokturk , Aksoy Sercan , Erman Mustafa , Yalcin Suayib , Urun Yuksel , Kilickap Saadettin
Published: July 2022

Objective: Treatment beyond progression (TBP) with immune checkpoint inhibitors (ICIs) is an evolving field due to the limitations of conventional imaging in response evaluation with ICIs. However, real-life data on the benefit of TBP is scarce, especially from the limited resource settings. Therefore, we aimed to investigate the survival benefit of TBP with ICIs in patients with advanced tumors from a limited resource setting.Methods: For this multicenter study, we included 282 patients treated with ICIs and radiological progression according to RECIST 1.1 criteria. The evaluated post-progression survival according to the use of TBP (TBP and non-TBP groups) with univariate and multivariate analyses.Results: 82 (29.1%) of 282 patients continued on ICIs following the initial progression event. In multivariate analyses, patients in the TBP group had improved post-progression survival compared to non-TBP (13.18 vs. 4.63 months, HR: 0.500, 95% CI: 0.349-0.717, p<0.001). The benefit of the TBP was independent of the tumor type, treatment line, and patient age. Furthermore, TBP with ICIs was associated with improved post-progression survival (HR: 0.600, 95% CI: 0.380-0.947, p=0.028) in the additional analyses after excluding the patients with no further treatment after progression in the non-TBP arm.Conclusions: In this study, we observed that patients receiving ICIs beyond progression had considerably longer survival. Continuation of ICIs after progression should be kept in mind as a reasonable management option for patients with advanced cancer, specifically for patients with limited alternative options.
Impacts of inclusion of folded geogrid on load-settlement behavior of a strip footing overlaid on fine sands
Authors: Ahmad Hussein
Published: July 2022

This paper describes experimental studies on a strip footing overlaid an unreinforced, planar geogrid-reinforced, and folded geogrid layers of fine sand subjected to static loading. The footing settlement was determined for plate loading of over 25 kN. The variables are assessed in the testing program including the number of planar geogrid layers, the position of the folded geogrid within the soil, the thickness of the geogrid folded layer, wraparound lap and overlap lengths of a folded geogrid, the spacing within geogrid folded layers, and several geogrid layers. The results indicated the superiority of footing performance as a result of static loading for geogrid folded reinforced sand than for planar geogrid reinforced sand. Besides, a critical region was found at a certain depth under the footing, where a geogrid folded results in increased footing settlement. This critical area affects the behaviour of the sandy soils with low footing width. As a result of static loading, the soil compacts within depth, and sand particles penetrate between the geogrid apertures. Then they accumulate in a specific area inside the geogrid folded, therefore it causes small gaps that leads to the rotation of the strip footing in the soil at the foundation surface. In total, based on the results, the reinforced soil-footing systems with adequate folding geogrid layers behave much stiffer, thus, they can handle higher loads with the lower settlement than those in planar reinforced soil. Also, the results show that the values of embedment depth and thickness of geogrid folded are 0.41 and 0.2 of the footing width, respectively. Consequently, the settlement rate is significantly reduced by increasing the amount of folded geogrid layers. The findings revealed that the wraparound technique solution for reinforced cases considerably improves the bearing capacity, reduces settlement, and uses in tight bed spaces.
Die Poetik des Versagens und Scheiterns im amerikanischen Kino
Authors:   , Hilfenhaus Dominik
Published: July 2022

Die diskursanalytische Dissertation beschäftigt sich mit der Frage, wie das amerikanische Kino von seinen Anfängen bis in die Gegenewart das Thema des Scheiterns und Versagens dargestellt hat. Ausgangspunkt der Arbeit ist dabei zunächst eine Einordnung und Differenzierung des Begriffspaares aus etymologischer Perspektive. Es wird bereits an dieser Stelle auf semantische Unterschiede verwiesen, denen sich divergierende Plotstrukturen anschließen: Die Geschichte des Versagens ist eine andere als die des Scheiterns. Außerdem werden anthropologische Erkenntnisse der Aufklärung benannt, die ein eigenständiges Scheitern und Versagen überhaupt erst ermöglichen. Im Anschluss an diese sprachtheoretische Untersuchung widmet sich die Arbeit den Besonderheiten des amerikanischen Narrativs des Scheiterns und Versagens und damit einer historischen Perspektivierung, die von der Analyse ausgewählter literarischer Texte abgeschlossen wird. Die Ergebnisse der sprachtheoretischen Untersuchung, der historischen Perspektivierung und der Literaturanalyse bilden schließlich das Fundament für die sich anschließende Filmanalyse, die die Frage stellt, wie tradierte Erzählformen des Scheiterns und Versagens ab dem 20. Jahrhundert in filmischer Form bestätigt, subvertiert oder gänzlich neu etabliert werden. Im Vordergrund steht hier zunächst das klassische Hollywood-Kino. Dabei wird grundsätzlich zwischen zwei unterschiedlichen Narrativen unterschieden: Dem Versagen und dem Scheitern. Im ersten Teil stehen die Versager, bewusste Aussteiger, die auf der Suche nach alternativen Lebensentwürfen sind. Bespiele hierfür sind der tramp Chaplins, der singende Obdachlose Bumper in Halleluja, I'm a Bum oder der glückliche Tunichtgut Thadeus Winship Page in The Magnificent Dope. Demgegenüber stehen die Figuren, die an äußeren Umständen scheitern und meist an diesen zerbrechen, wie die lost woman in Blonde Venus oder der forgotten man in I Am a Fugitive from a Chain Gang. Ziel der Analyse ist es, iterative Semantiken und syntaktische Strukturen zu benennen, die die Grundlage eigener Erzählgenres bilden, wie das des „Glücklichen Versagers“ oder der lost woman. Im letzten Kapitel werden die bisherigen Ergebnisse um Erkenntnisse erweitert, die sich dem modernen amerikanischen Kino entnehmen lassen. Ausgangspunkt ist das New Hollywood-Kino der 60er und 70er Jahre mit Filmen wie Easy Rider, The Graduate, oder The Swimmer. Auf der Reflexion über die eigene Tätigkeit liegt vor allem im letzten Teil dieses Kapitels der Schwerpunkt. Hier sind es vorwiegend Künstler des 21. Jahrhunderts, wie Drehbuchschreiber, Theaterregisseure oder Comicautoren, die ihre eigenen Handlungen in Frage stellen. Neu ist, dass sich das künstlerische Versagen der Protagonisten nicht nur innerhalb der Diegese auf den Film auswirkt, bzw. dessen Form modifiziert, sondern diese geradezu dekonstruiert und aufbricht.
QUALIDADE E SEGURANÇA NO CUIDADO EM TEMPOS DE COVID-19: COMPARAÇÃO DE INDICADORES ANTES E DURANTE A PANDEMIA
Authors: Costa Cássia Janne Nonato da , Martins Edna Thais Jeremias , Ribeiro Mara Regina Rosa , Ferreira Gímerson Erick
Published: July 2022

Objetivo: Realizar mapeamento diagnóstico de indicadores de qualidade e segurança do cuidado na atenção hospitalar, antes e durante a pandemia de COVID-19. Método: Estudo quantitativo, descritivo, retrospectivo, em que foram coletadas informações oriundas de notificações no VIGIHOSP, e de auditorias, no período de agosto de 2019 a agosto de 2020 em hospital universitário federal da região centro-oeste do Brasil, analisados por estatística básica e apresentação gráfica. Resultados: Durante a pandemia, constatou-se redução na incidência de infecção primária de corrente sanguínea laboratorial na UTI Adulto (10,8%) e Neonatal (8,7%), inclusive comparando com outros estudos; e aumento nas taxas de adesão à higienização das mãos pelos profissionais (73%) e na proporção de notificações (55%). Porém, constatou aumento na incidência de lesão por pressão (29,8%) e na taxa de mortalidade institucional (3,8%). Conclusão: A pesquisa aponta para a necessidade de orientar-se por resultados que agreguem valor à atenção hospitalar, assegure melhores taxas, evite never events e preserve ou potencialize padrões de qualidade e segurança, com vistas à eficiência e efetividade do cuidado.
Investigation of Flame Retardancy Effect of Licorice Root Extract on Cotton and Cotton-Polyester Blended Fabrics
Authors: KORUYUCU Aslıhan , BALABAN Fehmi Çağlar
Published: July 2022

In this study; licorice root, which is a sustainable natural material with a low environmental waste load, is used as an alternative fire retardant (FR) material. Flammable retardancy properties of 100% cotton and 50% cotton-50% polyester blended woven fabrics were researched by using licorice root and commercial organic phosphorus-nitrogen and phosphorus including compounds. Flame retardancy and thermal decay behaviour of the cotton and cotton/polyester blended fabric samples were qualified by the vertical burning test, limiting oxygen index (LOI), thermogravimetric analysis (TGA) and scanning electron microscope (SEM). The findings revealed that licorice root extracts enhanced the thermal behavior of the cotton and cotton/polyester blended fabrics after padding and coating processes. The practices increased the amount of oxygen demand for combustion in the environment and besides they did not change the morphological properties of the fabric samples. As a result, the usage of licorice root extracts considerably improved the fabric’s flammability under test.
Zemin Taşıma Gücü Haritalarının Oluşturulması: Altınşehir (Adıyaman) Örneği
Authors: SÖYLEMEZ Mehmet
Published: July 2022

Şehirlerin hızlı nüfus artışına uydu kentler, fabrikalar, üniversite kampüsleri ve alışveriş merkezleri gibi önemli mühendislik yapılarının hizmete girmesi önemli sebeplerdendir. Adıyaman ilinin gelişim sürekliliğine de 2006 yılında kurulan Adıyaman Üniversitesi önemli bir sebep olmuştur. Gelen yeni nüfusun konut ihtiyacı üniversite kampüsü civarı tarım arazilerinde, yapılaşmaya izin verilerek karşılanmıştır. Çalışma alanındaki en küçük ve en yüksek taşıma gücü değerleri sırasıyla 14,5 t / m2 ve 18,9 t / m2 dir. Taşıma gücü haritası NetCad programıyla sahanın 1/20000 ölçekli topoğrafik haritasına, derinliği 1,5-4 metre arasında değişen zemin taşıma gücü değerleri işlenerek çizilmiştir. Çizilen bu harita yardımıyla parsel bazında zemin araştırması yapılmayan bölgelerin de zemin taşıma gücü değerleri hesaplanabilir.
Волонтерская деятельность отряда «Капсула здоровья» по формированию культуры личной гигиены у младших школьников
Authors: Воропаева В. Н. , Колобаева М. П.
Published: July 2022

The article deals with the work of student volunteers to promote a healthy lifestyle, the rules of the culture of personal hygiene.
Приемы повышения активизации учащихся с помощью нестандартных вопросов
Authors: Назаров Ж.С. Э. , Ефремова Н. Н.
Published: July 2022

The article describes the experience of using techniques (information dosage, etc.) and methods (the “brainstorming” method) to increase the activation of students with the help of non-standard questions in higher education.
Голод как фактор распространения заразных заболеваний в Курской области в 1947 г.
Authors:   ОКУ «Госархив Курской области», Аргунов Олег
Published: July 2022

The famine of 1947 in the USSR is a direct consequence of the objective prerequisites that have developed in the country as a result of a combination of two factors: the consequences of the Great Patriotic War and the strongest famine in the entire 20th century. drought. One of the consequences of mass hunger strikes is the spread of contagious diseases among the population. This article is devoted to the extent to which this process was typical for the Kursk region.
Противотуберкулезные трехдневники как один из видов борьбы с туберкулезом в Белгородском уезде Курской губернии в 1920-е годы
Authors: Кистенева О. А. , Кистенев В. В.
Published: July 2022

The article presents data on the state of the county health care and the organization three days against tuberculosis, as one of the types of tuberculosis control in the Belgorod district of the Kursk province. It is noted that in the Belgorod district until 1926 there were no specialized medical institutions for tuberculosis patients. The work on anti-tuberculosis activities was carried out haphazardly. During the three-day, the population was taught the elementary rules of tuberculosis prevention and organized a fundraiser.
Взаимосвязь когнитивных особенностей и потребительского поведения личности
Authors: Сорокоумова Е. А. , Ферапонтова М. В. , Васильева А. С.
Published: July 2022

The article discusses the concept of consumer behavior and its study in the framework of psychological science. The determinism of consumer behavior by cognitive features is specified. The results of an empirical study of the relationship between individual consumer behavior and cognitive characteristics are presented.
Projecting aridity from statistically downscaled and bias-corrected variables for the Gediz Basin, Turkey
Authors: Kirdemir Umut , Okkan Umut , Fistikoglu Okan
Published: July 2022

Due to climatological changes, a study was conducted in the Gediz Basin, Turkey, where agricultural production holds an important place. In the study prepared, 12 general circulation models (GCMs) were utilized under representative concentration pathway (RCP)4.5, RCP6.0, and RCP8.5 scenarios of the fifth assessment report (AR5) of IPCC for the period 2015–2050. The statistical downscaling methods were employed and the projections were derived right after applying the weighted-averaged ensemble mean by the Bayesian Model Averaging (BMA) method and bias correction by equidistant quantile mapping (EDQM). The temperature-based potential evapotranspiration (PET) formulas were modified in accordance with the Penman–Monteith method and the aridity indexes were calculated by UNEP's formula. According to the projections, the mean annual temperature increases between 1.5 and 2.2 °C and the mean total annual PET increases between 5 and 8% are foreseen in the Gediz Basin for the near future. It is foreseen that a semi-arid climate regime may predominate over the region for all of the RCP scenarios under the increasing dryness in basin climate. In addition, it was obtained in the study that sub-humid climate state occurrence for all of the regions included by the basin may be unexpected in the future for the RCP8.5 scenario. The presence of semi-arid climate conditions may be more potent with the increasing trend of radiative forcing over time.
Effects of a Continuity of Preterm Infant Care Program on Parenting outcomes and Service Utilization Rates
Authors: Kaewwimol Patcharaporn , Ruchiwit Manyat , Liaw Jen-Jiuan
Published: July 2022

Background:

After transition to home, most preterm infants exhibit higher readmission rates due to lack of readiness for hospital discharge and inadequate discharge preparation. Continuity of care during transitional care is an essential intervention for achieving parental readiness and performance in this group.

Objective:

The study aims to analyze the effects of continuity of care program for parents with preterm infants (CCPI) on parental performances, parental readiness, and service utilization rates post-discharge.

Methods:

A randomized controlled trial evaluated 92 dyads of preterm infants and parents. They were randomly assigned to two groups. The experimental group received the CCPI with routine nursing care, and the control group received only routine nursing care. The parental readiness and parental performance questionnaires were completed by the parents and analyzed using analysis of covariance (ANCOVA). The effectiveness of the CCPI in reducing the service utilization rates post-discharge was demonstrated using RM-ANOVA.

Results:

The parents’ performance who participated in the CCPI was significantly higher, as was their readiness for hospital discharge than the parents of the control group (p< 0.01). In addition, the service utilization rates for the samples significantly decreased (p< 0.01) at the fourth week after discharge. However, there was no significant difference between the first- and second-week post-discharge.

Conclusion:

The study findings may help policymakers deploy the CCPI for parents with preterm infants while suggesting that the CCPI should be used to promote growing preterm infants to reduce post-discharge service utilization rates significantly.
The Value-driven Algorithmic Pathway
Authors: Rodgers Waymond
Published: July 2022

The Value Driven Algorithmic Pathway (P→I→J→D) designates how people or
organizational perceptual framing assists in guiding and selecting types of information
utilized in the judgmental stage. This algorithmic pathway is motivated by information
processing limitations, complexity, and coherence between perception and the available
information. Therefore, to take this algorithmic pathway, a person or organization’s
perception is modified and selected as the information that will be analyzed for a
decision choice. 
The Global Perspective Algorithmic Pathway
Authors: Rodgers Waymond
Published: July 2022

The Global Perspective Algorithmic Pathway (I→P→J→D) takes into deliberation all
types of information sources. This algorithmic pathway requests for an open-minded
approach in which all possible information sources will be considered that can assist to
update and modify a person or organization’s perceptual frame. This process begins
with information revising perception, followed by judgment to the decision choice.
This algorithmic pathway is most ideal when there are no time pressures that will
bound the time it takes to assemble the information and analyze the problem.
Moving Forward with Throughput Modelling and Advancing Technologies
Authors: Rodgers Waymond
Published: July 2022

AI and related digital technologies have practically weaved its way through everything
the 21st Century is tied to for performance and productivity. It provides individuals and
organizations with a better, closer, more holistic view of solutions as never before. For
most organizations, speed is essential on today’s landscape. Furthermore, AI, machine
learning, deep learning, natural language processing, big data, and other digital
technologies assist individuals and organizations to collaborate with others in real time
and connect processes and data to rapidly build trust and confidence.