bluuebunny/crossref_metadata_2025 huggingface dataset:
Elective Nodal Irradiation or Involved-Field Irradiation in Definitive Chemoradiotherapy for Esophageal Squamous Cell Cancer: A Retrospective Analysis in Clinical N0 Patients
Authors: Sun Y. , Zhang X.L. , Mao Q.F. , Liu Y.H. , Kong L. , Li M.H.
Published: November 2018

Objective: We compared failure patterns and survival after elective nodal irradiation (eni) or involved-field irradiation (ifi) in patients with thoracic esophageal squamous cell carcinoma (escc), clinical stage T2–4N0M0, to determine whether ifi is feasible for such patients. Methods: Between 2005 and 2015, 126 patients with clinical stage T2–4N0M0 thoracic escc who received definitive concurrent chemoradiotherapy in Shandong Cancer Hospital and Institute and who had complete data, were analyzed retrospectively. Of those patients, 49 received ifi, and 77 received eni. In the ifi group, the radiation field included the primary tumour, with a 3-cm to 4-cm margin in the craniocaudal direction, and the elective irradiation was delivered to the adjacent regional lymphatics according to the location of the primary tumour. Patterns of failure were classified using the first site of failure, which included primary tumour failure, regional lymph node failure, and distant metastasis. Results: Median progression-free survival was 20 months [95% confidence interval (ci): 7.87 months to 39.2 months] in the ifi group and 30 months (95% ci: 17.4 months to 44.6 months) in the eni group (p = 0.580). Median overall survival (os) was 36 months (95% ci: 21.9 months to 50.1 months) in the ifi group and 38 months (95% ci: 26.1 months to 49.9 months) in the eni group (p = 0.761). The estimated 1-year, 3-year, and 5-year os rates were, respectively, 87.8%, 49.4%, and 32.3% for the ifi patients and 92.2%, 52.0%, and 28.9% for the eni patients. Disease persistence and primary lesion recurrence after complete remission (cr) were the most frequent causes of treatment failure in the patients overall (83 of 124, 66.9%). Of the 66 patients achieving a clinical cr, 25 experienced recurrence of the primary lesion, 12 experienced distant relapse, 10 experienced regional nodal failure, and 2 experienced an isolated recurrence. No significant differences in the pattern of failure or in the incidences of grade 3 or greater treatmentrelated myelosuppression or esophagitis were found between the ifi and eni groups. Conclusions: In patients with thoracic escc clinical stage T2–4N0M0 receiving definitive chemoradiotherapy, failure patterns and os were similar with either eni or ifi. Large prospective randomized studies are needed to further investigate and verify those results in this subgroup of patients.
Patients with Non-Small-Cell Lung Cancer Harbouring a BRAF Mutation: A Multicentre Study Exploring Clinical Characteristics, Management, and Outcomes in a Real-Life Setting: EXPLORE GFPC 02-14
Authors: Auliac J.B. , Bayle S. , Vergnenegre A. , Le Caer H. , Falchero L. , Gervais R. , Doubre H. , Vinas F. , Marin B. , Chouaid C.
Published: November 2018

Background: Mutations in BRAF are rare oncogene mutations, found in 2% of non-small-cell lung cancers (NSCLCS). Little information is available about the management of patients with BRAF-mutated nsclc, except for those included in clinical trials. We undertook the present study to assess the clinical characteristics, management, and outcomes of those patients in a real-life setting. Methods: This retrospective multicentre observational study included all patients with BRAF-mutated nsclc diagnosed between January 2012 and December 2014. Results: Patients (n = 59) from 24 centres were included: 57.6% men; mean age: 64.5 ± 14.5 years; 82% with a performance status of 0–1 at diagnosis; smoking status: 40.3% current, 32.6% former; 93% with adenocarcinoma histology; 75% stage iv; 78% with V600E mutations; 2 with EGFR and 2 with ALK co-mutations. Of the stage iv patients, 79% received first-line therapy (14.2% anti-BRAF), and 48% received second-line treatment (23.8% anti-BRAF). Response rate and progression-free survival were, respectively, 51.7% and 8.7 months [95% confidence interval (CI): 6.4 months to 15.2 months] for first-line therapy and 35.3% and 4.1 months (95% CI: 2 months to 10.9 months) for second-line treatments. The 2-year overall survival was 58.5% (95% CI: 45.8% to 74.8%). Outcomes in patients with stage iv nsclc harbouring BRAF V600E mutations (n = 32) did not differ significantly from those of patients with other BRAF mutations. Conclusions: In this real-world analysis, most nsclc patients with a BRAF mutation were men and current or former smokers. Survival appears to be better in these BRAF-mutated patients than in nsclc patients without an oncogenic driver.
Are Patient-Reported Outcomes of Physical Function a Valid Substitute for Objective Measurements?
Authors: Douma J. A. J. , Verheul H. M. W. , Buffart L. M.
Published: November 2018

Background Physical function is important for defining treatment strategies in patients with cancer and can be estimated using patient-reported outcomes (pros). Although pros are subjective, physical activity and fitness can be tested objectively with adequate, but more labour-intensive methods that are rarely used in daily clinical practice. To determine whether pros for physical function (pro-pf) accurately predict physical function, we studied their interrelationships with objective measures of physical activity and fitness in patients with cancer who had completed cancer treatment, including adjuvant or neoadjuvant chemotherapy or autologous stem-cell transplantation. Methods Baseline data from the react (Resistance and Endurance Exercise After Chemotherapy) and exist (Exercise Intervention After Stem-Cell Transplantation) studies were evaluated. In those studies, the effects of an exercise intervention on physical fitness, fatigue, and health-related quality of life in patients with cancer shortly after completion of chemotherapy or stem-cell transplantation were studied. Interrelationships between pro-pf (physical function subscale of the European Organisation for Research and Treatment of Cancer 30-question core Quality of Life Questionnaire), physical activity (accelerometer), and cardiorespiratory fitness (peak oxygen uptake) were assessed using univariable and multivariable multilevel linear mixed-model analyses. Results After adjustment for age, sex, and body mass index, the pro-pf was significantly associated with physical activity (β = 1.75; 95% confidence interval: 1.08 to 2.42) and cardiorespiratory fitness (β = 0.10; 95% confidence interval: 0.06 to 0.13). Standardized coefficients were 0.28 and 0.26 respectively, indicating a weak association. Conclusions The pro-pf is only weakly associated with objective physical activity and fitness evaluation in patients after curative treatment for cancer. The pro-pf cannot, therefore, be used in clinical practice as a substitute for objective measures of physical function.
Immune-Related Adverse Events of Immune Checkpoint Inhibitors: A Brief Review
Authors: Myers G.
Published: November 2018

Immune checkpoint inhibitors (ICIS) such as inhibitors of CTLA-4, PD-1, and PD-L1, given as monotherapy or combination therapy have emerged as effective treatment options for immune-sensitive solid tumours and hematologic malignancies. The benefits of icis can be offset by immune-related adverse events (irAES) that leave all organ systems vulnerable and subsequently increase the risk for morbidity and mortality. Because of fluctuating onset and prolonged duration, the toxicities associated with iraes represent a shift from the understanding of conventional anticancer toxicities. The CTLA-4 and PD-1/PD-L1 inhibitors odulate T-cell response differently, resulting in distinct toxicity patterns, toxicity kinetics, and dose–toxicity relationships. Using individualized patient education, screening, and assessment for the early identification of iraes is key to proactive management and is therefore key to improving outcomes and prolonging therapy. Management of irAES is guided by appropriate grading, which sets the stage for the treatment setting (outpatient vs. inpatient), ICI treatment course (delay vs. discontinuation), supportive care, corticosteroid use, organ specialist consultation, and additional immunosuppression. Health care professionals in oncology must work collaboratively with emergency and community colleagues to facilitate an understanding of irAES in an effort to optimize seamless care.
Treatment Algorithm in Cancer-Associated Thrombosis: Canadian Expert Consensus
Authors: Carrier M. , Blais N. , Crowther M. , Kavan P. , Le Gal G. , Moodley O. , Shivakumar S. , Tagalakis V. , Wu C. , Lee A.Y.Y.
Published: November 2018

Management of anticoagulant therapy for the treatment of venous thromboembolism (VTE) in cancer patients is complex because of an increased risk of recurrent VTE and major bleeding complications in those patients relative to the general population. Subgroups of patients with cancer also show variation in their risk for recurrent VTE and adverse bleeding events. Accordingly, a committee of 10 Canadian clinical experts developed the consensus risk- stratification treatment algorithm presented here to provide guidance on tailoring anticoagulant treatment choices for the acute and extended treatment of symptomatic and incidental VTE, to prevent recurrent VTE, and to minimize the bleeding risk in patients with cancer. During a 1-day live meeting, a systematic review of the literature was performed, and a draft treatment algorithm was developed. The treatment algorithm was refined through the use of a Web-based platform and a series of online teleconferences. Clinicians using this treatment algorithm should consider the bleeding risk, the type of cancer, and the potential for drug–drug interactions in addition to informed patient preference in determining the most appropriate treatment for patients with cancer-associated thrombosis. Anticoagulant therapy should be regularly reassessed as the patient’s cancer status and management change over time.
Canadian Perspectives: Update on Inhibition of ALK-Positive Tumours in Advanced Non-Small-Cell Lung Cancer
Authors: Melosky B. , Cheema P. , Agulnik J. , Albadine R. , Bebb D.G. , Blais N. , Burkes R. , Butts C. , Card P.B. , Chan A.M.Y. , Hirsh V. , Ionescu D.N. , Juergens R. , Morzycki W. , Poonja Z. , Sangha R. , Tehfe M. , Tsao M.S. , Vincent M. , Xu Z. , Liu G.
Published: November 2018

Background: Inhibition of the anaplastic lymphoma kinase (ALK) oncogenic driver in advanced non-small-cell lung carcinoma (NSCLS) improves survival. In 2015, Canadian thoracic oncology specialists published a consensus guideline about the identification and treatment of ALK-positive patients, recommending use of the ALK inhibitor crizotinib in the first line. New scientific literature warrants a consensus update. Methods: Clinical trials of ALK inhibitor were reviewed to assess benefits, risks, and implications relative to current Canadian guidance in patients with ALK-positive NSCLS. Results: Randomized phase III trials have demonstrated clinical benefit for single-agent alectinib and ceritinib used in treatment-naïve patients and as second-line therapy after crizotinib. Phase II trials have demonstrated activity for single-agent brigatinib and lorlatinib in further lines of therapy. Improved responses in brain metastases were observed for all second- and next/third-generation ALK tyrosine kinase inhibitors in patients progressing on crizotinib. Canadian recommendations are therefore revised as follows: (1) Patients with advanced nonsquamous NSCLS have to be tested for the presence of an ALK rearrangement. (2) Treatment-naïve patients with ALK-positive disease should initially be offered single-agent alectinib or ceritinib, or both sequentially. (3) Crizotinib-refractory patients should be treated with single-agent alectinib or ceritinib, or both sequentially. (4) Further treatments could include single-agent brigatinib or lorlatinib, or both sequentially. (5) Patients progressing on ALK tyrosine kinase inhibitors should be considered for pemetrexed-based chemotherapy. (6) Other systemic therapies should be exhausted before immunotherapy is considered. Summary: Multiple lines of ALK inhibition are now recommended for patients with advanced NSCLS with an ALK rearrangement.
Peritoneal Dialysis for Patients with End-Stage Renal Disease and Liver Cirrhosis
Authors: Khan Sana , Rosner Mitchell H.
Published: November 2018

End-stage renal disease patients with cirrhosis represent a therapeutic dilemma, with several difficulties associated with hemodialysis as a renal replacement therapy modality. Peritoneal dialysis is a feasible option for these patients, despite the confounders of associated infection risk, malnutrition, ascites management, and mechanical complications. This review covers the existing data on the outcomes and complications associated with the use of peritoneal dialysis in the cirrhotic patient.
Changing Dialysis Modality during Pregnancy: A Case Report
Authors: Shaw James , Katopodis Christina , Hladunewich Michelle A. , Ryz Krista
Published: November 2018

Pregnancy in patients with end-stage renal disease is rare, with a paucity of management guidelines in the literature. Various hemodialysis (HD) and peritoneal dialysis (PD) protocols have been used to successfully manage pregnancy in this population; however, there is a growing body of evidence that the best maternal and fetal outcomes are associated with intensified, high-dose HD. The optimal timing of transition from PD to HD is not known for prevalent PD patients who become pregnant. We report the case of a 32-year-old aboriginal female who became pregnant while being treated with chronic PD. She was converted to intensive HD early in the second trimester and underwent a planned caesarian section at 36 weeks with excellent outcomes for mother and child.
Gastric Electrical Stimulation Improves Symptoms of Diabetic Gastroparesis in Patients on Peritoneal Dialysis—2 Case Reports
Authors: Majanovic Sanja Klobucar , Zelic Marko , Belancic Andrej , Licul Vanja , Vujicic Božidar , Girotto Neva , Štimac Davor
Published: November 2018

Diabetic gastroparesis (DGP), a delay in gastric emptying without obstruction to outflow as a complication of diabetes, typically develops after at least 10 years of diabetes. Cardinal symptoms include nausea, vomiting, early satiety, bloating, and upper abdominal pain. The aim of DGP treatment is to alleviate the severity and frequency of symptoms, improve the level of gastric emptying, ameliorate the patient's nutritional status and to optimize glycemic control. In the treatment of chronic drug-refractory nausea and vomiting secondary to DGP, gastric electrical stimulation (GES) such as Enterra Therapy System (Medtronic Inc., Minneapolis, MN, USA) can be considered. It is well established that diabetic nephropathy is the most common cause of end-stage renal disease (ESRD) requiring renal replacement therapy. The exact prevalence of patients with severe DGP and ESRD is not known; however, finding a therapeutic approach to these patients, particularly those whose gastroparesis symptoms preclude them from undergoing kidney transplant procedure, represents a huge challenge. Our experience suggests that GES implantation can be an effective treatment modality for type 1 diabetic patients on peritoneal dialysis (PD) who are simultaneous pancreas-kidney transplantation candidates, by improving the severity and frequency of gastroparesis symptoms and eventually ensuring their optimal nutritional and fluid intake.
The Binary Fraction of Stars in Dwarf Galaxies: The Cases of Draco and Ursa Minor
Authors: Spencer Meghin E. , Mateo Mario , Olszewski Edward W. , Walker Matthew G. , McConnachie Alan W. , Kirby Evan N.
Published: November 2018

Measuring the frequency of binary stars in dwarf spheroidal galaxies (dSphs) requires data taken over long time intervals. We combine radial velocity measurements from five literature sources taken over the course of ∼30 years to yield the largest multi-epoch kinematic sample for stars in the dSphs Draco and Ursa Minor. With this data set, we are able to implement an improved version of the Bayesian technique described in Spencer et al. to evaluate the binary fraction of red giant stars in these dwarf galaxies. Assuming Duquennoy & Mayor period and mass ratio distributions, the binary fractions in Draco and Ursa Minor are

and

, respectively. We find that a normal mass ratio distribution is preferred over a flat distribution, and that log-normal period distributions centered on long periods (

) are preferred over distributions centered on short ones. We reanalyzed the binary fractions in Leo II, Carina, Fornax, Sculptor, and Sextans, and find that there is <1% chance that binary fraction is a constant quantity across all seven dwarfs, unless the period distribution varies greatly. This indicates that the binary populations in Milky Way dSphs are not identical in regard to their binary fractions, period distributions, or both. We consider many different properties of the dwarfs (e.g., mass, radius, luminosity, etc.) and find that binary fraction might be larger in dwarfs that formed their stars quickly and/or have high velocity dispersions.
The California-Kepler Survey. VI. Kepler Multis and Singles Have Similar Planet and Stellar Properties Indicating a Common Origin∗
Authors: Weiss Lauren M. , Isaacson Howard T. , Marcy Geoffrey W. , Howard Andrew W. , Petigura Erik A. , Fulton Benjamin J. , Winn Joshua N. , Hirsch Lea , Sinukoff Evan , Rowe Jason F. ,   The California Kepler Survey
Published: November 2018

The California-Kepler Survey (CKS) catalog contains precise stellar and planetary properties for the Kepler planet candidates, including systems with multiple detected transiting planets (“multis”) and systems with just one detected transiting planet (“singles”, although additional planets could exist). We compared the stellar and planetary properties of the multis and singles in a homogeneous subset of the full CKS-Gaia catalog. We found that sub-Neptune-sized singles and multis do not differ in their stellar properties or planet radii. In particular: (1.) The distributions of stellar properties

, [Fe/H], and

for the Kepler sub-Neptune-sized singles and multis are statistically indistinguishable. (2.) The radius distributions of the sub-Neptune-sized singles and multis with P > 3 days are indistinguishable, and both have a valley at ∼1.8

. However, there are significantly more detected short-period (P < 3 days), sub-Neptune-sized singles than multis. The similarity of the host-star properties, planet radii, and radius valley for singles and multis suggests a common origin. The similar radius valley, which is likely sculpted by photo-evaporation from the host star within the first 100 Myr, suggests that planets in both singles and multis spend much of the first 100 Myr near their present, close-in locations. One explanation that is consistent with the similar fundamental properties of singles and multis is that many of the singles are members of multi-planet systems that underwent planet–planet scattering.
Limits on Clouds and Hazes for the TRAPPIST-1 Planets
Authors: Moran Sarah E. , Hörst Sarah M. , Batalha Natasha E. , Lewis Nikole K. , Wakeford Hannah R.
Published: November 2018

The TRAPPIST-1 planetary system is an excellent candidate for study of the evolution and habitability of M-dwarf-hosted planets. Transmission spectroscopy observations performed on the system with the Hubble Space Telescope (HST) suggest that the innermost five planets do not possess clear hydrogen atmospheres. Here we reassess these conclusions with recently updated mass constraints. Additionally, we expand the analysis to include limits on metallicity, cloud top pressure, and the strength of haze scattering. We connect recent laboratory results of particle size and production rate for exoplanet hazes to a one-dimensional atmospheric model for TRAPPIST-1 transmission spectra. In this way, we obtain a physically based estimate of haze scattering cross sections. We find haze scattering cross sections on the order of 10−26–10−19 cm2 are needed in modeled hydrogen-rich atmospheres for TRAPPIST-1 d, e, and f to match the HST data. For TRAPPIST-1 g, we cannot rule out a clear hydrogen-rich atmosphere. We model the effects an opaque cloud deck and substantial heavy element content have on the transmission spectra using the updated mass estimates. We determine that hydrogen-rich atmospheres with high-altitude clouds, at pressures of 12 mbar and lower, are consistent with the HST observations for TRAPPIST-1 d and e. For TRAPPIST-1 f and g, we cannot rule out clear hydrogen-rich cases to high confidence. We demonstrate that metallicities of at least 60× solar with tropospheric (0.1 bar) clouds are in agreement with observations. Additionally, we provide estimates of the precision necessary for future observations to disentangle degeneracies in cloud top pressure and metallicity. For TRAPPIST-1 e and f, for example, 20 ppm precision is needed to distinguish between a clear atmosphere and one with a thick cloud layer at 0.1 bar across a wide range (1× to 1000× solar) of metallicity. Our results suggest secondary, volatile-rich atmospheres for the outer TRAPPIST-1 planets d, e, and f.
Tracing Outflowing Metals in Simulations of Dwarf and Spiral Galaxies
Authors: Christensen Charlotte R. , Davé Romeel , Brooks Alyson , Quinn Thomas , Shen Sijing
Published: November 2018

We analyze the metal accumulation in dwarf and spiral galaxies by following the history of metal enrichment and outflows in a suite of 20 high-resolution simulated galaxies. These simulations agree with the observed stellar and gas-phase mass–metallicity relation, an agreement that relies on large fractions of the produced metals escaping into the circumgalactic media. For instance, in galaxies with M
vir ∼ 109.5–1010

, we find that about ∼85% of the available metals are outside of the galactic disk at z = 0, although the fraction decreases to a little less than half in Milky-Way-mass galaxies. In many cases, these metals are spread far beyond the virial radius. We analyze the metal deficit within the ISM and stars in the context of previous work tracking the inflow and outflow of baryons. Outflows are prevalent across the entire mass range, as is reaccretion. We find that between 40% and 80% of all metals removed from the galactic disk are later reaccreted. The outflows themselves are metal-enriched relative to the ISM by a factor of 0.2 dex because of the correspondence between sites of metal enrichment and outflows. As a result, the metal mass loading factor scales as

, a somewhat shallower scaling than the total mass loading factor. We analyze the simulated galaxies within the context of analytic chemical evolution models by determining their net metal expulsion efficiencies, which encapsulate the rates of metal loss and reaccretion. We discuss these results in light of the inflow and outflow properties necessary for reproducing the mass–metallicity relation.
Resolving Star Formation on Subkiloparsec Scales in the High-redshift Galaxy SDP.11 Using Gravitational Lensing*
Authors: Lamarche C. , Verma A. , Vishwas A. , Stacey G. J. , Brisbin D. , Ferkinhoff C. , Nikola T. , Higdon S. J. U. , Higdon J. , Tecza M.
Published: November 2018

We investigate the properties of the interstellar medium, star formation, and the current-day stellar population in the strongly lensed star-forming galaxy H-ATLAS J091043.1-000321 (SDP.11), at z = 1.7830, using new Herschel and Atacama Large Millimeter/submillimeter Array (ALMA) observations of far-infrared fine-structure lines of carbon, oxygen, and nitrogen. We report detections of the [O iii] 52 μm, [N iii] 57 μm, and [O i] 63 μm lines from Herschel/PACS, and present high-resolution imaging of the [C ii] 158 μm line, and underlying continuum, using ALMA. We resolve the [C ii] line emission into two spatially offset Einstein rings, tracing the red and blue velocity components of the line, in the ALMA/Band 9 observations at 0.″2 resolution. The values seen in the [C ii]/far-infrared (FIR) ratio map, as low as ∼0.02% at the peak of the dust continuum, are similar to those of local ULIRGs, suggesting an intense starburst in this source. This is consistent with the high intrinsic FIR luminosity (∼3 × 1012
L
⊙), ∼16 Myr gas depletion timescale, and ≲8 Myr timescale since the last starburst episode, estimated from the hardness of the UV radiation field. By applying gravitational lensing models to the visibilities in the uv-plane, we find that the lensing magnification factor varies by a factor of two across SDP.11, affecting the observed line profiles. After correcting for the effects of differential lensing, a symmetric line profile is recovered, suggesting that the starburst present here may not be the result of a major merger, as is the case for local ULIRGs, but instead could be powered by star formation activity spread across a 3–5 kpc rotating disk.
OGLE-2017-BLG-0039: Microlensing Event with Light from a Lens Identified from Mass Measurement
Authors: Han C. , Jung Y. K. , Udalski A. , Bond I. , Bozza V. , Albrow M. D. , Chung S.-J. , Gould A. , Hwang K.-H. , Kim D. , Lee C.-U. , Kim H.-W. , Ryu Y.-H. , Shin I.-G. , Yee J. C. , Shvartzvald Y. , Cha S.-M. , Kim S.-L. , Kim D.-J. , Lee D.-J. , Lee Y. , Park B.-G. , Pogge R. W. ,   (The KMTNet Collaboration), Szymański M. K. , Mróz P. , Skowron J. , Poleski R. , Soszyński I. , Kozłowski S. , Pietrukowicz P. , Ulaczyk K. , Pawlak M. ,   (The OGLE Collaboration), Abe F. , Barry R. , Bennett D. P. , Bhattacharya A. , Donachie M. , Evans P. , Fukui A. , Hirao Y. , Itow Y. , Kawasaki K. , Koshimoto N. , Li M. C. A. , Ling C. H. , Matsubara Y. , Miyazaki S. , Munakata H. , Muraki Y. , Nagakane M. , Ohnishi K. , Ranc C. , Rattenbury N. , Saito T. , Sharan A. , Sullivan D. J. , Sumi T. , Suzuki D. , Tristram P. J. , Yamada T. , Yonehara A. ,   (The MOA Collaboration)
Published: November 2018

We present an analysis of the caustic-crossing binary microlensing event OGLE-2017-BLG-0039. Thanks to the very long duration of the event, with a time scale t
E ∼ 130 days, the microlens parallax is measured precisely despite its low value of

. Analysis of the well-resolved caustic crossings during the source star’s entrance and exit of the caustic yields an angular Einstein radius of

mas. The measured

and

indicate that the lens is a binary composed of two stars with masses

and ∼0.15 M
⊙, and is located at a distance of ∼6 kpc. From the color and brightness of the lens estimated from its determined mass and distance, it is expected that ∼2/3 of the I-band blended flux comes from the lens. Therefore, the event is a rare case of a bright lens event for which high-resolution follow-up observations can confirm its nature.
SN 2017ens: The Metamorphosis of a Luminous Broadlined Type Ic Supernova into an SN IIn
Authors: Chen T.-W. , Inserra C. , Fraser M. , Moriya T. J. , Schady P. , Schweyer T. , Filippenko A. V. , Perley D. A. , Ruiter A. J. , Seitenzahl I. , Sollerman J. , Taddia F. , Anderson J. P. , Foley R. J. , Jerkstrand A. , Ngeow C.-C. , Pan Y.-C. , Pastorello A. , Points S. , Smartt S. J. , Smith K. W. , Taubenberger S. , Wiseman P. , Young D. R. , Benetti S. , Berton M. , Bufano F. , Clark P. , Valle M. Della , Galbany L. , Gal-Yam A. , Gromadzki M. , Gutiérrez C. P. , Heinze A. , Kankare E. , Kilpatrick C. D. , Kuncarayakti H. , Leloudas G. , Lin Z.-Y. , Maguire K. , Mazzali P. , McBrien O. , Prentice S. J. , Rau A. , Rest A. , Siebert M. R. , Stalder B. , Tonry J. L. , Yu P.-C.
Published: November 2018

We present observations of supernova (SN) 2017ens, discovered by the ATLAS survey and identified as a hot blue object through the GREAT program. The redshift z = 0.1086 implies a peak brightness of M

g
 = −21.1 mag, placing the object within the regime of superluminous supernovae. We observe a dramatic spectral evolution, from initially being blue and featureless, to later developing features similar to those of the broadlined Type Ic SN 1998bw, and finally showing ∼2000 km s−1 wide Hα and Hβ emission. Relatively narrow Balmer emission (reminiscent of a SN IIn) is present at all times. We also detect coronal lines, indicative of a dense circumstellar medium. We constrain the progenitor wind velocity to ∼50–60 km s−1 based on P-Cygni profiles, which is far slower than those present in Wolf–Rayet stars. This may suggest that the progenitor passed through a luminous blue variable phase, or that the wind is instead from a binary companion red supergiant star. At late times we see the ∼2000 km s−1 wide Hα emission persisting at high luminosity (∼3 × 1040 erg s−1) for at least 100 day, perhaps indicative of additional mass loss at high velocities that could have been ejected by a pulsational pair instability.
Notulae to the Italian native vascular flora: 6
Authors: Bartolucci Fabrizio , Domina Gianniantonio , Ardenghi Nicola M.G. , Bacchetta Gianluigi , Bernardo Liliana , Buccomino Giovanni , Buono Sergio , Caldararo Franco , Calvia Giacomo , Carruggio Francesca , Cavagna Alessandro , D’Amico Francesco S. , Di Carlo Francesco , Festi Francesco , Forte Luigi , Galasso Gabriele , Gargano Domenico , Gottschlich Günter , Lazzaro Lorenzo , Magrini Sara , Maiorca Giovanni , Medagli Pietro , Mei Giacomo , Mennini Flavio , Mereu Giuliano , Miserocchi Danio , Olivieri Nicola , Passalacqua Nicodemo G. , Pazienza Gaetano , Peruzzi Lorenzo , Prosser Filippo , Rempicci Massimiliano , Roma-Marzio Francesco , Ruggero Alessandro , Sani Alessandra , Saulle Domenico , Steffanini Chiara , Stinca Adriano , Terzi Massimo , Tondi Giancarlo , Trenchi Maurizio , Viciani Daniele , Wagensommer Robert P. , Nepi Chiara
Published: November 2018

In this contribution, new data concerning the distribution of native vascular flora in Italy are presented. It includes new records, confirmations and status changes to the Italian administrative regions for taxa in the generaAlchemilla,Arundo,Bupleurum,Clematis,Clinopodium,Cota,Crassula,Cytisus,Euphorbia,Hieracium,Isoëtes,Lamium,Leontodon,Linaria,Lychnis,Middendorfia,Ophrys,Philadelphus,Pinus,Sagina,Sedum,Taeniatherum,Tofieldia,Triticum,Veronica, andVicia. Nomenclature and distribution updates, published elsewhere, and corrigenda are provided as supplementary material.
Le travail, peut-il encore être la santé ?
Authors: Di Liberatore Dominique
Published: November 2018

Le travail tel qu’il faut le considérer aujourd’hui, avec son organisation, sa répartition des tâches et des fonctions, avec sa gestion et sa communication, avec toutes les avancées sociales que ce soit la législation, la sécurité, les assurances, avec aussi toutes les diverses instances, internes ou externes à l’entreprise, ce travail donc, offre-t-il encore aux personnes un lieu de sublimation, de transfert ou de répétition de leurs problématiques personnelles ? Et jusqu’à quel point ne les crée-t-il pas ou ne les aggrave-t-il pas ?
Le burnout des médecins (et celui des psychologues, infirmiers, magistrats, chercheurs et enseignants)
Authors: Unger Jean-Pierre
Published: November 2018

Le burnout des médecins prend une ampleur épidémique, comme d’ailleurs celui des professionnels de tous les secteurs à finalité sociale. Après en avoir décrit la pathologie, cet article élabore le caractère multidisciplinaire de la prise en charge clinique. Pour la prévention, il décrit l’importance de la gestion à finalité professionnelle et sociale des services de santé, des tribunaux, des universités et des écoles. Il en oppose les caractéristiques à celles de la gestion à finalité industrielle et commerciale.
Du travail éprouvant aux éprouvés du travail
Authors: Girard Noémie , Joud Charlyne , Duret Isabelle
Published: November 2018

À partir de situations cliniques issues de nos travaux de recherche, nous avons interrogé la souffrance portée par la voix des psychologues exerçant en clinique traumatique. S’intéresser à ce qui se vit et s’éprouve dans la relation thérapeutique nous a amenées à proposer la métaphore de l’infusion. Nous avons établi un parallèle entre l’infusion de thé et le cadre thérapeutique, partant du constat que le psychologue en clinique traumatique peut être réceptacle d’infusions troublantes. La rencontre peut devenir source de vécus douloureux et émerge alors la nécessité de trouver une échappatoire, une voie d’issue à cette situation complexe pour le clinicien.
Forensic Psychiatry and Consultation-Liaison Psychiatry: Exciting Subspecialties with Bright Futures
Authors: Ostermeyer Britta , Perdue Jedidiah , Keller Johanna , Dukes Charles H.
Published: November 2018

Additional training in psychiatric subspecialties has been increasingly recognized as a way to prepare psychiatrists to successfully manage more difficult and complex patient circumstances. This article describes the practice activities and scope of training for forensic psychiatry and consultation-liaison (CL) psychiatry. Forensic psychiatry fellowship training prepares psychiatrists to manage medical/psychiatric legal scenarios, ranging from patient-care legal issues to performing legal expert witness consultations for third parties, including courts and attorneys, as well as correctional mental health. CL psychiatry training prepares psychiatrists to master the care of patients with complex medical and psychiatric illnesses as well as to work effectively in multidisciplinary medical teams and integrated medical psychiatric care settings.

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Psychiatr Ann
. 2018;48(11):509–515.]
Subspecialty Training in Sleep Medicine for Psychiatrists
Authors: Carter Gregory , Khawaja Imran S. , Louis Erik St.
Published: November 2018

Sleep medicine is a multidisciplinary field with growth potential. Sleep and psychiatric disorders are comorbid. Many psychiatrists were at the forefront during the earlier years of the field and played significant roles during critical developments of the field. Today there is a shortage of psychiatrists trained in sleep medicine in the United States, with many psychiatry residents not knowing that subspecialty training in sleep medicine is an option. Psychiatrists trained in sleep medicine can bridge the gap between nonpsychiatric and mental health providers to increase awareness of the impact sleep disorders have on mental health and improve care of the patients.

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Psychiatr Ann
. 2018;48(11):520–523.]
On Modern Computer Assisted Language Learning Facilities and its Integrated Teaching
Authors: Bai Yucheng
Published: November 2018

The teaching model of computer Assisted Language Learning Facilities and its integrated teaching become the new perspective on the reform of college English Teaching in China. Its invention and implementation provide a powerful cognitive tool for English listening, speaking, reading and writing for students’ comprehensive quality improvement. This paper focus on how to make full use of the advantages of multimedia and network, and explore computer assisted language learning and teaching model of English major curriculum integration. At the same time, this study put forwarder the facilities concrete implementation method and problems that should pay attention to in English major teaching.
An Automatic Classification and Clustering Algorithm for Online Learning Goals Based on Cognitive Thinking
Authors: Wang Ying , Jiang Weifeng
Published: November 2018

To improve the learning effect of online learning, an online learning target automatic classification and clustering analysis algorithm based on cognitive thinking was proposed. It was applied to a multi-dimensional learning community. A new form of virtual learning community concept was proposed. The design ideas of its multi-dimensional learning environment were elaborated. Ontology technology was used to collect student learning process data. A cognitive diagnostic model for assessing student learning status was generated. Finally, through the cluster analysis technology, the registered students in the curriculum center were automatically divided into different levels of community groups. The results showed that the proposed algorithm for automatic classification and clustering of online learning targets had a good application effect in the learning community. Therefore, this method has practical application value.
An Educational Data Mining Model for Supervision of Network Learning Process
Authors: Chen Jianhui , Zhao Jing
Published: November 2018

To improve the school's teaching plan, optimize the online learning system, and help students achieve better learning outcomes, an educative data mining model for the supervision of the e-learning process was established. Statistical analysis and visualization in data mining techniques, association rule algorithms, and clustering algorithms were applied. The teaching data of a college English teaching management platform was systematically analyzed. A related conclusion was drawn on the relationship between students' English learning effects and online learning habits. The results showed that this method could effectively help teachers judge students' online learning results, understand their online learning status, and improve their online learning process. Therefore, the model can improve the effectiveness of students' online learning.
Design of Heterogeneous Data Exchange Technology for Teaching Resources Based on ICMPv6
Authors: Fang Wei
Published: November 2018

To promote the innovation of teaching resources and heterogeneous data exchange platform technologies and theories, heterogeneous data exchange platforms based on ICMPv6 teaching resources were studied. First, based on ICMPv6, the middle-tier architecture of the heterogeneous data exchange platform for teaching resources was studied. Second, the application layer architecture in the heterogeneous data exchange platform system of educational resources was studied. The middle layer and application layer were designed and implemented. Finally, the system was applied to the education platform to reflect its performance. The results showed that the ICMPv6 system could solve data exchange and data sharing systems between schools and homes. Contributions were made in solving interactive education between home and school. To sum up, it is feasible to use ICMPv6 on heterogeneous educational resources exchange platform.
Educational Resource Management in Grid Community Based on Learning Object Metadata Standard
Authors: Chen Yuhang
Published: November 2018

To manage the educational resources of the grid community based on the standard of learning object metadata, the resource classification standard of the learning object metadata standard is taken as the basis of the grid community division. According to the principle of the classification of educational resources, and based on the characteristics of the grid management system and the features of the grid community, the construction and internal structure of grid community are discussed, and the idea of constructing peer community group is proposed. In accordance with the idea of peer community, similar educational resources achieve a logical connection between peer communities. The results show that the mechanism of information sharing and information diffusion is established among communities, and the framework of educational resource management is constructed through simulation and evaluation.
The Construction and Application of a Personalized Teaching Space in Mobile English
Authors: Jin Ning , Yan Zhengkun
Published: November 2018

This paper designs the construction dimension of College English individualized teaching space, and constructs its system architecture combining with the requirements of teaching and learning cloud space. Secondly, it expounds the four application strategies of learning cloud space in College English Teaching: individualized spatial dynamic allocation strategy, self-taught strategy under the support of experience, and based on the ubiquitous environment. Fragmented learning strategy and language learning oriented interactive dialogue strategy; finally, it introduces three application patterns in College English Teaching in the light of learning cloud space: overturning, subject inquiry learning and mixed teaching, and verifying the use effect of cloud space through case studies. The results show that customized learning cloud space and its application can improve the efficiency of College English teaching and promote students'mastery of English application skills.
L’opéra italien à la cour de France : réception et adaptation d’un objet étranger (1645-1662)
Authors: Nestola Barbara
Published: November 2018

Si les circonstances de la réception de l’opéra italien en France au xviie siècle sont aujourd’hui connues, il reste tout de même encore des questions ouvertes concernant les modalités effectives de l’acclimatation de ce répertoire à la cour. Malgré les efforts de Mazarin pour italianiser le milieu musical français, les opéras italiens donnés entre 1645 et 1662 ont été soumis à des réadaptations orientées vers une francisation, de nature artistique ou politique, au moment d’être présentés au public de la cour. Ce processus s’est déroulé par phases et en suivant plusieurs étapes : dans les années 1645-1647, il concerne principalement le texte et la musique des opéras, tandis que dans la période suivante, 1654-1662, les remaniements interviennent d’une manière plus envahissante par l’insertion d’éléments issus de genres musicaux français, tel le ballet de cour. Parallèlement, avec l’entrée du roi dans l’âge adulte, l’ingérence d’éléments politiques se fait tangible, notamment après la disparition de Mazarin. Le propos de cette étude est d’explorer ce croisement d’influences et de montrer comment l’objet « opéra italien » a progressivement été dévêtu de ses connotations artistiques saillantes pour répondre aux enjeux de nature artistique et politique propres au contexte de la cour dans la période charnière de la passation du pouvoir entre Mazarin et Louis XIV.
Reconstituer Marly
Authors: Queval Hélène
Published: November 2018

De formation académique, gravitant autour d’Eugène Viollet-le-Duc et participant à de nombreuses éditions d’ouvrages d’architecture, ainsi qu’annuellement au Salon des artistes français, le dessinateur et graveur d’architecture Auguste-Alexandre Guillaumot (1815-1892) resta associé au domaine de Marly, qu’il arpenta à maintes reprises pendant trente ans à la recherche de points de vue à croquer et qu’il chercha à faire revivre dans sa monographie. Par une consultation assidue des dessins et estampes témoignant de l’apparence du château de Marly et conservés à la Bibliothèque nationale de France et aux Archives nationales, ainsi que par l’étude des vestiges exhumés lors des premières fouilles sur le site réalisées à son instigation, Guillaumot s’attela à la difficile tâche d’évoquer un monument disparu quasi intégralement depuis un demi-siècle. Il mit en œuvre une réflexion intellectuelle et artistique originale, mêlant archéologie de papier et archéologie de terrain. Ses croquis, conservés en grand nombre au Musée-Promenade de Marly-le-Roi / Louveciennes, témoignent des sources iconographiques consultées et des étapes artistiques entre le matériau archivistique et les gravures finales.
Formation Mechanism of Gehlenite-Anorthite Materials Containing ZrO2 from Andalusite, CaCO3 and ZrO2
Authors: Śnieżek Edyta , Ludwig Maciej , Szczerba Jacek
Published: November 2018

This paper reports the results of using natural andalusite (Al2SiO5) in combination with CaCO3 and ZrO2 in order to obtain aluminosilicate product. This work was devoted to the study of the mechanism of new phases creation in the Al2SiO5-CaO-ZrO2 phase system during heating at different temperatures (1000, 1100, 1200, 1300 and 1400°C). Al2SiO5, CaCO3, and ZrO2 were used in a weight ratio of 45:50:5, respectively. According to the phase composition and chemical analysis in microareas, it was found, that andalusite reacted with CaO giving two calcium aluminosilicates: gehlenite and anorthite at 1400°C. ZrO2 was presented as the separated phase at this temperature. Other occurring transition phases were: CaZrO3 at 1000 and 1200°C, Ca2SiO4 at 1000, 1100 and 1200°C, Ca3ZrSi2O9 at 1300°C. The synthesis mostly depended on the diffusion of Ca2+ ions.
Research on Properties of High Performance Foamed Concrete
Authors: Namsone Eva , Sahmenko Genadijs , Namsone Elvija , Korjakins Aleksandrs
Published: November 2018

The research is devoted to foamed concrete, which is a very perspective material in the modern construction industry. Foamed concrete is lightweight concrete and is in accordance with compressive strength and the use of it: constructive, constructive-insulating and lightweight foamed concrete.
Processing of Dolomitic By-Products into Porous Restoration Binder
Authors: Kirilovica Inta , Sučevana Viktorija
Published: November 2018

The goal of this work concerns the synthesis of a binder for restoration purposes that is physically and chemically compatible with dolomitic Roman cement, a historical binder used for the construction of significant architectural heritage objects in the 19thand 20thcenturies. Dolomitic marlstone, the traditional raw material of dolomitic Roman cement, is not being obtained anymore and it is also hard to achieve a constant chemical composition. To address these issues, the experimental synthesis of a low temperature hydraulic binder using locally sourced raw materials, namely dolomite flour and clay, was performed. The developed synthesis technology provides economic and ecological advantages compared to other similar materials, such as lime with pozzolan additive, lime and cement mixtures and magnesium oxychloride cements. The raw material, dolomite flour, is a by–product in the manufacturing process; furthermore, the low firing temperature (800 °C) reduces the power consumption required to obtain the binder.The aim of the work is determination of porosity-related physical characteristics of dolomitic binder that is synthesized by using manufacturing by-product – dolomite flour – as basic raw material to evaluate it’s suitability for restoration purposes.
Alkali-Activated Binder from Tungsten Mining Waste and Waste Glass
Authors: Kastiukas Gediminas , Zhou Xiang Ming
Published: November 2018

A foamed alkali-activated material (FAAM), based on tungsten mining waste (TMW) and waste glass (WG) was fabricated by using chemical foaming and pre-formed foaming methods. The compressive strength and density of the FAAM were investigated in terms of different parameters of formulation including foaming method, foam catalyzing agent and stabilizing agent. A FAAM made with aluminium powder consisted of smaller open macropores and exhibited higher compressive strength in comparison with organic surfactant counterparts which formed larger closed macropores. The final aluminium powder based FAAM reached a 7-day compressive strength in excess of 3 MPa and a density below 0.7 g/cm3. The incorporation of an appropriate amount of foam stabilizer led to a further 15% increase in compressive strength, 6% reduction in density and a thermal conductivity below 0.1 W/mK.