bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiogenesis in psoriasis as a therapeutic target (literature review)
Authors: Kochergin Nikolay G. , Brezhneva Anna A. , Yazkova Olga S. , Fadeev Alexander A.
Published: July 2024

One of the characteristic features of psoriasis is increased vascularization in the psoriatic plaque. It is known that this process occurs as a result of pathological angiogenesis, which leads to an increase of blood vessels in the lesion, increased proliferation of endothelial cells, vasodilation and increased permeability of the vascular wall, facilitating penetration of immune cells and increasing inflammation. Many signaling molecules are involved in the process of angiogenesis in psoriasis. The most important indicator of the severity of pathological angiogenesis is endothelial vascular growth factor (VEGF). The issue of using blood serum analysis for endothelial vascular growth factor (VEGF) and diagnostic imaging techniques of the vascular network in psoriatic plaques to determine the severity of the process and the possibility of using additional treatment directions aimed at reducing vascularization is being considered. At the moment, the mechanisms of angiogenesis in psoriasis are being actively studied, and the possibilities of therapeutic influence on this link of pathogenesis are especially interesting.
The authors present an analysis of the current literature on this topic, and suggest possible available treatment strategies based on the data obtained. Further research in this direction is needed to optimize the therapy of psoriasis, the main purpose of which will be to reduce the duration of treatment and prolong the time of remission.
The relationship of microbial biodiversity and clinical forms of oral lichen planus: analysis based on 16S rRNA sequencing
Authors: Teplyuk Natalya P. , Stepanov Mikhail A. , Damdinova Baira Sh. , Toshchakov Stepan V. , Noskov Sergey A. , Tutubalina Nina A.
Published: July 2024

BACKGROUND: The composition and changes of microbiota have a significant impact on overall health and the development of various diseases. Of particular relevance is the problem of changes in the oral microbiota in patients with lichen planus of the oral mucosa. Studying the relationship between the composition of the oral microbiota and the pathogenesis of oral lichen planus will improve the understanding of the mechanisms of this disease. Thus, this topic is of considerable interest to a wide range of specialists in the field of medicine and biology.
AIM: Detailed analysis of oral cavity microbiota and establishment of potential pathogenetic microbial associations with oral lichen planus.
MATERIALS AND METHODS: The study included samples from patients diagnosed with various forms of oral red squamous lichen planus (lichen planus erosive-ulcerative) and a control group. The investigation was based on analyzing microbial diversity metrics (alpha and beta diversity), relative abundance of bacterial taxa, and identification of unique bacterial taxa in the oral red squamous lichen planus patients. This analysis utilized the 16S rRNA sequencing method.
RESULTS: The analysis revealed a rich bacterial composition in patients with oral lichen planus, which was significantly different from that in the control group. Differences were also observed between the subgroups, especially between the typical and erosive-ulcerative forms of the disease. Notably, beta diversity did not show significant differences between the groups, indicating a similar overall microbiota composition despite fluctuations in the relative abundance of species. Nevertheless, the typical clinical form of the disease demonstrated more significant differences in the microbiota structure compared to the hyperkeratotic and erosive-ulcerative forms. Furthermore, analysis of the study groups revealed the presence of 50% shared microbial species, while the other half was represented by unique species associated with oral lichen planus. Regarding the subgroups, it was found that unique microorganisms correlated with the typical and erosive-ulcerative forms, respectively, providing a deeper understanding of the specific microbiological profile in the context of this disease.
CONCLUSION: The study confirmed the hypothesis of an association between the microbiota composition and oral lichen planus, which may be of importance for the development of novel therapeutic approaches.
Chronicles of A.I. Pospelov Moscow Society of Dermatovenerologists and Cosmetologists (MSDС was founded on October 4, 1891) Bulletin of the MSDС № 1156
Authors: Yakovlev Alexey B. , Maximov Ivan S. , Petukhova Eugenia V.
Published: July 2024

On February 20th we held our last meeting of A.I. Pospelov Moscow Society of Dermatologists and Cosmetologists in person.
There were 115 participants and 3 applicants.
Our agenda included four reports. The first speaker reported a clinical case of cytostatic therapy ineffectiveness in a patient with pustular psoriasis (State Scientific Center of Dermatovenereology and Cosmetology); the second case was about the adverse dermatological reactions in patients receiving pembrolizumab and nivolumab for hepatocellular cancer (Sechenov University).
Two reports were presented in the scientific part of the meeting: the first report was about the clinical features of perianal dermatoses (Russian Medical Academy of Continuous Professional Education), the second one was based on the diagnosis of erythroderma (Sechenov University).
Periostin as a marker of eosinophilic inflammation in patients with asthma and chronic obstructive pulmonary disease
Authors: Kuznetsov Valeriy D. , Kozlova Yana I. , Frolova Ekaterina V. , Uchevatkina Aleksandra E. , Filippova Larisa V. , Aak Oleg V. , Vasilieva Natalya V.
Published: July 2024

BACKGROUND: Asthma and chronic obstructive pulmonary disease are common chronic respiratory diseases. Given their heterogeneity, the study of periostin is a relevant area for establishing the endotypes of airway inflammation and determining further therapy tactics.
AIM: To evaluate periostin levels and determine its significance as a marker of eosinophilic inflammation in patients with asthma and chronic obstructive pulmonary disease.
MATERIALS AND METHODS: The study included 59 patients with asthma and 33 patients with chronic obstructive pulmonary disease. The control group consisted of 37 apparently healthy people, comparable in age and sex, without allergic and bronchial obstructive diseases in anamnesis. The anamnesis data, the number of peripheral blood eosinophils and induced sputum, indices of external respiratory function were evaluated. Levels of specific immunoglobulin E to allergens, periostin level were determined in blood serum by immunoenzyme method. The obtained data were processed using STATISTICA 13 and SPSS Statistic 27 software systems.
RESULTS: The maximum serum periostin concentration 22.5 (17–38) ng/ml was recorded in the patients with asthma, which was significantly higher than in the chronic obstructive pulmonary disease group [16 (12–21) ng/ml; p = 0.006] and control group [20.1 (14.6–24.8) ng/ml; p = 0.044]. The level of periostin in induced sputum in the patients with asthma was significantly higher than in the chronic obstructive pulmonary disease group — 0.05 (0.03–0.6) ng/ml vs 0.03 (0.02–0.04) ng/ml (p = 0.008). The study revealed the correlation between serum periostin level and eosinophil level (r = 0.406; p 0.05) and with forced expiratory volume in the first second after bronchodilator test (r = 0.366; p 0.05) as well as with forced expiratory volume in the first second divided by forced vital capacity after bronchodilator test (r = 0.572; p 0.05).
CONCLUSIONS: Periostin is a promising marker of eosinophilic inflammation in patients with asthma, which can be considered as an indicator of fixed bronchial obstruction and a molecule linking T2-inflammation and airway remodelling. In a group of chronic obstructive pulmonary disease patients, the use of periostin for diagnostic and prognostic purposes requires further investigation and larger studies.
Integrated Amphibious Distributed Acoustic Sensing for Seismic Monitoring in the Xinfengjiang Reservoir
Authors: Li Chao , Jiang Xingda , Xu Min , Huang Haocai , Xiao Zhuo , Li Yuejin , Lin Zehui , Cui Hongxing , Cang Siyuan , Cui Xiaoming , Zhou Yong , Yang Huayong
Published: July 2024

The rapidly advancing technology of distributed acoustic sensing (DAS) has profoundly impacted the field of underwater geophysics. Our study investigates the effectiveness of DAS in underwater geological stability monitoring, with a particular focus on microseismic monitoring in the Xinfengjiang reservoir. The 6.2 km long acquisition setup, covering both land and reservoir bottom, was verified using temporary shore-based short-period seismometers to ensure reliable data acquisition in various environments. Higher background noise was observed on the land section compared with the lakebed section during the day, whereas both sections exhibited similar noise levels at night. We confirmed that the DAS system was capable of detecting distant microseismic events, some of which were previously unreported. These detections exhibited temporal and phase consistency with neighboring seismometers. Comparison of signal-to-noise ratios indicates that the lakebed section demonstrates higher sensitivity. This system delivers cost-effective performance through natural settling, negating the requirement for costly embedding methods. Moreover, the DAS system identified “comet-like” small-scale signals on the lakebed that had eluded shore-based seismometers. This exemplifies the exceptional high-density and high-resolution capabilities of DAS technology in both aquatic and terrestrial environments. This study underscores the pivotal role of the DAS technology in conducting underwater microseismic monitoring, real-time seismic monitoring, seismic mechanism research, and earthquake hazard assessment.
Assessing the Predictive Power of GPS-Based Ground Deformation Data for Aftershock Forecasting
Authors: Schimmenti Vincenzo Maria , Petrillo Giuseppe , Rosso Alberto , Landes Francois P.
Published: July 2024

We present a machine learning approach for aftershock forecasting of the Japanese earthquakes catalog. Our method takes as sole input the ground surface deformation as measured by Global Positioning System (GPS) stations on the day of the mainshock to predict aftershock location. The quality of data heavily relies on the density of GPS stations: the predictive power is lost when the mainshocks occur far from measurement stations, as in offshore regions. Despite this fact and the small number of samples and the large number of parameters, we are able to limit overfitting, which shows that this new approach is very promising.
The Need for Sport Social Workers in College Athletics
Authors: Judge Lawrence W. , Smith Adam , Reynolds Jerry
Published: July 2024

College sports place significant pressure on student-athletes and necessitate the recognition and resolution of social, emotional, and environmental needs. To provide comprehensive support, the integration of social work professionals with sport expertise in college athletic departments is proposed. By encompassing mental health support, advocacy, and the resolution of challenges pertaining to well-being and identity, the application of social work principles provides student-athletes a well-rounded college athletic experience. Education and training for sport social workers are highlighted as crucial aspects for effectively navigating the complexities of college athletics. These specialized programs equip social workers with the necessary skills and knowledge to provide effective support to student-athletes. By considering their unique needs within the college context, sport social workers can contribute to the development and success of student-athletes. This article emphasizes the significance of addressing the well-being of student-athletes in college athletics through the integration of sport social work principles. In doing so, a supportive environment can be cultivated, promoting the student-athletes’ overall development and success. A focus on inclusivity and the application of social work principles in youth sports further highlights the broader impact that social work can have in addressing social issues.
Front Matter
Authors: Law Review Indiana
Published: July 2024

Includes Tribute to Paul Galanti by Gerald L. Bepko.
Mucous membrane pemphigoid of the oral cavity and Genitalia: A case report
Authors: Mehra Garima , Mahajan Aarti , Agarwal Gaurav
Published: July 2024

Mucous membrane pemphigoid (MMP) encompasses a diverse array of chronic autoimmune conditions characterized by the development of blisters predominantly affecting mucous membranes in various regions of the body. Commonly impacted areas include the mouth, mucosal linings of the eyes, throat, genitalia, and nasal passages. While MMP typically manifests in older women, with peak incidence occurring between 50 and 70 years of age, rare instances have been observed in children. Symptoms of MMP often entail recurrent blister formation, subsequent rupture, and potential scarring, with complications possibly affecting the eyes and throat. This article presents a unique case involving a 70-year-old female presenting with lesions localized to the oral and vaginal mucosa. A comprehensive discussion on histopathological examination findings and treatment modalities is provided. Notably, the absence of ocular involvement in this case distinguishes it from typical presentations of MMP.
Controle e Transparência em Instituições Federais de Educação Superior: um Estudo Exploratório da Universidade Aberta do Brasil
Authors: Santos Andrey Anderson dos , Bianchi Isaías Scalabrin , Bahia Eliana Maria dos Santos
Published: July 2024

O objetivo do artigo é analisar se as universidades aderentes ao Sistema Universidade Aberta do Brasil (UAB) seguem o princípio constitucional de publicidade mediante a transparência ativa em seus sites institucionais. Este é um estudo exploratório com abordagem qualitativa, de natureza aplicada. Os resultados foram obtidos por levantamento documental a partir dos sites institucionais de 26 universidades federais aderentes ao Sistema UAB. A relevância do estudo está nas recomendações para as universidades federais implantarem ações que aperfeiçoam a transparência. Propõem-se ferramentas de gestão aplicáveis em seus portais eletrônicos, uma vez que esses assumem o papel de melhorar a eficiência da transparência das instituições. Conclui-se que a mesma Tecnologia da Informação e Comunicação que viabiliza a mediação pedagógica na UAB é apta para aperfeiçoar o nível de transparência da gestão.  
 
Palavras-chave: Educação a distância. Governo aberto. Gestão universitária.
“Cultura Maker para Educadores”: um Projeto de Curso Híbrido Baseado em MOOC
Authors: Andrade Fabiana , Félix Livia Chagas
Published: July 2024

O crescimento da Cultura Maker na educação e implementação de Laboratórios Maker em algumas escolas tem proporcionado uma demanda para formação continuada de professores. O objetivo desta pesquisa é descrever o desenvolvimento do projeto de um curso híbrido baseado em MOOC para educadores. O curso tem como metas introduzir a Cultura Maker e destacar suas potencialidades na educação, apresentar as principais ferramentas e equipamentos, ilustrar noções de funcionamento, exemplificar suas aplicações voltadas ao ensino e aplicar os conhecimentos adquiridos à prática em sala de aula. A metodologia de desenvolvimento do projeto do curso foi baseada no modelo ADDIE. O resultado é um curso que une teoria à prática em momentos presenciais e online, e que pode contribuir para a formação de professores de diversas áreas e para o campo de pesquisa ainda recente no Brasil dos MOOC híbridos. 
 
Palavras-chave: Educação a distância. MOOC híbrido. Cultura Maker. Formação de professores.
A Cognição Distribuída e o Ensino Híbrido: uma Teoria para Pensar as Tecnologias
Authors: Franca Creuza Martins , ZIirond Maria Ilza , Mello Diene Eire de , Moraes Dirce Aparecida Foletto
Published: July 2024

Este artigo busca realizar algumas aproximações entre a Teoria da Cognição Distribuída e o Ensino Híbrido na relação com o aprendizado no âmbito das tecnologias. Como referencial teórico, baseia-se nos pressupostos dos estudos vigotskianos de desenvolvimento humano, a partir da perspectiva histórico-cultural, em diálogo com a Cognição distribuída. Por isso, o foco deste estudo são os modelos de Ensino Híbrido por meio de propostas e ações que contribuam com o aprendizado, conciliando momentos virtuais e presenciais. Para isso, foram explorados artigos científicos de uma base de dados, sob uma abordagem qualitativa e em uma perspectiva analítica. Fundamentada na Teoria da Cognição Distribuída, a análise dos dados concluiu que os processos educativos no contexto híbrido devem considerar um aporte teórico, tendo em vista o contexto da cultura digital em que o analógico e o on-line cada vez mais se imbricam. Portanto, o entendimento em relação aos conhecimentos que são construídos/constituídos e se distribuem nesses meios tecnológicos, nos auxilia na busca por caminhos de um ensino e uma aprendizagem mais colaborativos e interativos, nos quais possam ser observados os processos de cognição de maneira distribuída. 
 
Palavras-chave: Cognição distribuída. Ensino. Híbrido. Processos de ensino e aprendizagem.
Acoustic measurements of the Indonesian oral monophthongs produced by Acehnese speakers
Authors: Yusuf Yunisrina Qismullah ,   Universitas Syiah Kuala, Alfata Muhammad , Silviyanti Tgk. Maya , Iskandar Denni , Fata Ika Apriani ,   Universitas Syiah Kuala,   Universitas Syiah Kuala,   Universitas Syiah Kuala,   Universitas Syiah Kuala
Published: July 2024

This study explores the characteristics of Indonesian oral monophthong vowels produced by male and female language consultants in Banda Aceh, Indonesia, as their first language. Using purposive sampling, ten Acehnese males and ten Acehnese females were selected to articulate eight target vowels: /i/, /e/, /ɛ/, /ә/, /a/, /u/, /o/, and /ɔ/. Vowel measurements were obtained through recorded word elicitation, using a word list containing the target vowels. F1 and F2 frequencies in Hertz were determined and analyzed using Praat software to assess vowel qualities and subsequently converted to the Bark scale. Vowels were plotted on the F1/F2 formant space. The findings illustrate the distinct measurements of each Indonesian monophthong vowel by male and female consultants, represented in the vowel space. Male vowels generally exhibit higher and more centralized positioning, while female vowels appear more dispersed and lower. This research contributes valuable insights for comparing vowel systems across various languages and dialects spoken in multilingual Indonesia.
On estimating the size of informative fragments in the sea surface images
Authors: Chernomorets Darya Andreevna ,   Belgorod State National Research University, Chernomorets Andrey Alekseevich , Bolgova Evgeniya Vitalievna , Petina Maria Aleksandrovna ,   Belgorod State National Research University,   Belgorod State National Research University,   Belgorod State National Research University
Published: July 2024

The paper proposes a solution to one of the problems arising in the construction of modern traffic safety systems in marine areas, namely, estimating the size of informative fragments in the image, which it seems advisable to use when detecting foreign objects on the sea surface image. It is proposed to estimate the size of informative fragments based on calculating the average distance between the contours of the wave elements visible in the image, such as their crests, depressions, etc. The contours of these wave elements are determined based on the Canny operator. The estimation of the sizes of informative fragments is performed along the columns and rows of the analyzed image. Computational experiments have been carried out to illustrate the developed algorithm efficiency. The obtained estimates of the sizes of informative fragments of sea surface images seem appropriate to use in their analysis, in particular, when solving problems of detecting foreign objects on sea surface images.
Investigation of authentication methods on web services. Current trends and development prospects
Authors: Abselyamov Amet-Han Alim-ogly ,   Sevastopol State University, Lagutkina Tatyana Vladimirovna ,   Sevastopol State University
Published: July 2024

In the development of information technology, software and data protection on web services are of great importance. To ensure security, various methods are used, and one of the main ones is the user authentication process. They use different authentication methods: password, two-factor authentication, biometric, multi-factor, based on artificial intelligence and blockchain technologies. Despite their diversity, each method has its own advantages and disadvantages. Current trends in authentication include combining different methods to increase reliability and improve the user experience. The future of this technology involves finding new ways to balance security and usability, as well as continually updating and adapting methods to changing security threats. This article conducts a study of various authentication methods for web services in order to identify their effectiveness, advantages and disadvantages.
Интраназальное введение антагониста рецептора грелина [D-Lys-3]-GHRP-6 снижает проявления импульсивности и компульсивности, вызванные материнской депривацией у крыс
Authors: Пюрвеев Сарнг С. , Лебедев Андрей А. , Бычков Евгений Р. , Шабанов Петр Д.
Published: July 2024

Введение. Целью настоящего исследования было изучение интраназального введения антагониста рецептора грелина [D-Lys-3]-GHRP-6 на импульсивность и компульсивность в модели игровой зависимости у взрослых крыс после материнской депривации в раннем онтогенезе.
Материалы и методы. Крысята подвергались материнской (МД) ежедневно в течение 3 часов с 2 по 12 послеродовой день. Далее половозрелые крысы обучались в тесте вероятности и величины подкрепления IOWA Gambling task трехрукавном лабиринте в течение 21 дня. Каждая побежка в 1 рукав лабиринта с режимом подкрепления FR1 подкреплялась двумя пищевыми таблетками. Каждая вторая побежка во 2 рукав лабиринта с режимом подкрепления FR2 подкреплялась тремя пищевыми таблетками; каждая третья побежка в 3 рукав с режимом подкрепления FR3 подкреплялась четырьмя пищевыми таблетками. Соответственно, половина заходов в рукав 2 и 2/3 заходов в рукав 3 оставались без подкрепления. Для оценки компульсивного поведения животных также тестировали в тесте закапывания шариков. Крысу помещали в клетку с опилками и стеклянными шариками на 30 минут, после чего считали количество шариков, покрытых опилками более чем на 2/3.
Результаты и обсуждение. В группе МД количество заходов в 3 рукав увеличилось в 1,5 раза, что свидетельствует о выборе большего подкрепления при низкой вероятности его получения. Количество заходов в рукав 1 уменьшилось по сравнению с контрольной группой. Интраназальное введение селективного антагониста рецептора GHSR1A [D-Lys (3)]-GHRP-6 (1 мг/мл) животным МД приводило к достоверному (p<0,01) увеличению количества посещений 1 рукава. Кроме того, наблюдалась тенденция к уменьшению количества зарытых шариков у крыс, получавших [D-Lys (3)]-GHRP-6.
Заключение. Таким образом, работа показывает, что хронический стресс МД приводит к поведенческой стратегии у животных, направленной на получение более значительного пищевого подкрепления, но с низкой вероятностью его достижения, что связано с увеличением импульсивного компонента игровой зависимости. МД также вызывает увеличение количества закопанных шариков в тесте с закапывания шариков, что связано с увеличением компульсивного компонента игровой зависимости. Интраназальное введение антагониста GHS-R1a [D-Lys (3)]-GHRP-6 крысам МД значительно снижает повышенную импульсивную активность в тесте вероятности и величины подкрепления. Полученные данные открывают возможность создания лекарств, мишенью которых могут быть рецепторы грелина. Интраназальный метод введения пептидных веществ, использованный в работе, подтверждает возможность использования этого метода введения.
Synthesis and pharmacological activity of various organic and inorganic salts of phenyl derivatives of imidazobenzimidazole
Authors: Zhukovskaya Olga N. , Eliseeva Natalya V. , Vassiliev Pavel M. , Pridvorov Gleb V. , Grechko Olesya Yu. , Morkovnik Anatoly S. , Spasov Alexander A.
Published: July 2024

Introduction: The creation of new opioid analgesics that are devoid of the main undesirable effects – euphoria, respiratory depression, tolerance – is an important task for the treatment of pain syndrome. Eighteen salts of 9-pyrrolidinoethyl-(1a), 9-piperidinoethyl-(1b), and 9-morpholinoethyl-2-(4-fluorophenyl)benzo[d]imidazo[1,2-a]imidazole (1c) were synthesized and tested for kappa agonist and analgesic activity.
Materials and Methods: Specific analgesic activity studies were conducted using models of nociceptive pain in the “Hot/Cold-plate” and ”Plantar Test” tests, and in neuropathic pain against the background of sciatic nerve ligation. The relationship between the physicochemical and pharmacological properties of the compounds was studied in silico using quantum chemistry methods and artificial neural network technology.
Results: The most active compound identified was 4-(2-(2-(4-fluorophenyl)-benzo[d]imidazo[1,2-a]imidazol-9-yl)ethyl)morpholine dihydrochloride (1c.2HCl). EC50, acute toxicity, and conditional therapeutic index values were calculated, which were 38.8 times superior to the kappa agonist U50488. It was established that compound 1c.2HCl exhibits a dose-dependent analgesic effect in the “Hot/Cold-plate” test, which is six times superior to that of butorphanol, maintaining a statistically significant effect for six hours in the “Plantar test” and without causing the formation of tolerance with a ten-day administration. In models of neuropathic pain syndrome, 1c.2HCl with a fourteen-day administration significantly reduced tactile and cold allodynia by three and 1.6 times, respectively, and was not inferior in activity to gabapentin. The kappa-opioidergic mechanism of the antinociceptive action of 1c.2HCl compound was confirmed. Quantum chemistry methods and artificial neural network technologies have shown that the high level of kappa-opioid agonist activity of hydrochlorides, in contrast to other salts, results in lower total energy production; therefore, there is a significant increase in energy during the formation of a salt supramolecular complex.
Conclusion: The most active compound was identified – 1c.2HCl, for which kappa-opioid activity in vitro and analgesic properties were revealed in various in vivo models. It has been shown that the compound does not cause the formation of tolerance and is not toxic.
Internal conflict of personality and its connection with indicators of the formation of the professional self in the structure of individuality among students of psychological specialties
Authors: Belykh Tatiana V. ,   Saratov State University
Published: July 2024

Introduction. The article presents the results of an empirical study aimed at identifying the peculiarities of the connection between the severity of internal conflict and a complex of psychological and socio-psychological characteristics of an individual in the structure of individuality as a subject of professional socialization. Theoretical analysis. The analysis of research results in the scientific literature revealed the presence of conflicting data regarding the connection between internal conflict and the productivity of professional activities, including representatives of helping professions. Empirical analysis. Correlation connections have been identified that allow us to draw a conclusion about the role of the severity of an individual’s internal conflict in the formation of professionally significant personal and socio-psychological properties in the structure of individuality, ensuring the success of mastering and implementing professional activities by future psychologists. Conclusion. Internal conflict in future psychologists can be combined with low levels of self-regulation and volitional efforts, difficulties in demonstrating the “Adult” ego-position in conditions of interpersonal interaction, but at the same time, internal conflict does not prevent the manifestation of responsiveness and sincerity in conditions of contact interaction as professionally significant qualities formed in the conditions of professional socialization.
The structure and factors of academic adjustment of foreign students in Russian universities
Authors: Shamionov Rail’ M. ,   Saratov State University
Published: July 2024

Introduction. Academic adaptation of foreign students in terms of academic mobility is the basis of academic achievements and is associated with psychological well-being, which serves as a condition for a positive attitude towards the host country. Therefore, the study of the peculiarities of academic adaptation of foreign students will allow us to determine the conditions for their secondary socialization and psychological acceptance of the host country. Theoretical analysis. Academic adaptation of foreign students is associated with problems of cultural stress, awareness, socio-psychological relations of the host party, knowledge of the language for establishing contacts and interaction with local students and everyday problems. Academic problems themselves are considered to a lesser extent. Empirical analysis. The purpose of the study is to analyze the structure and factors of academic adaptation of foreign students. It is assumed that the social characteristics of the academic adaptation of foreigners (communicative, personal) are more pronounced than the psychophysiological ones, reflecting the physical well-being of students, the subjective assessment of their exhaustion and fatigue. Conclusion. As a result of the research, the indicators of personal, emotional and motivational and lower psychophysiological components of academic adaptation were found to be more pronounced than those of Russians. The adaptation of foreign students is conditioned by satisfaction of the basic need for connectedness with others, characterizing the possibilities of their support from relatives, connectedness with them, adaptation of Russian students - with satisfaction of the need for connectedness with others, competence, happiness and life satisfaction. Involvement in the educational activity of students, regardless of their residence status, is the most important factor in academic adaptation.
The Effect of Progesterone Elevation on the Day of Trigger Administration: A Review of the Literature
Authors: Jreij Chris , Halimeh Rawad , Fadel Doha , Chamoun Perla , Nassar Jean , Saab Wael , Seshadri Srividya , Bersaoui Marianne
Published: July 2024

Since the advent of assisted reproductive technology, different variables have been shown to affect pregnancy outcomes. One of the most prevalent studied events is the premature rise in serum progesterone concentrations on the day of trigger administration during cycles of ovarian stimulation. This phenomenon, classically known as premature luteinization, has been observed significantly for decades and has been linked to adverse pregnancy outcomes and lower live birth rates. Ultimately, a quest to find a precise serum progesterone concentration cut-off value that can be effectively used to predict pregnancy outcomes prior to trigger administration is still underway. The purpose of the current research was to study the available literature on the relationship between serum progesterone on the day of trigger administration in controlled ovarian stimulation cycles used for IVF in an attempt to identify a cut-off serum progesterone concentration that can be used to effectively predict future pregnancy outcomes in fresh transfers. This study is a review of the literature and is based on information and data gathered from 36 published articles. The majority of the literature shows that a serum progesterone concentration cut-off of 1.5 ng/ml (4.77 nmol/L) can be used prior to trigger administration to effectively predict pregnancy outcomes. Premature progesterone elevation on the day or prior to the trigger administration is associated with adverse pregnancy outcomes in IVF cycles. Other factors such as follicle number, serum concentration of other hormones, and ovarian response to ovarian stimulation should also be considered to predict the success of IVF protocols.
Improving Deep Learning-Based Algorithm for Ploidy Status Prediction Through Combined U-NET Blastocyst Segmentation and Sequential Time-Lapse Blastocysts Images
Authors: Handayani Nining , Danardono Gunawan Bondan , Boediono Arief , Wiweko Budi , Sini Ivan , Sirait Batara , Polim Arie A , Suheimi Irham , Bowolaksono Anom
Published: July 2024

Background: Several approaches have been proposed to optimize the construction of an artificial intelligence-based model for assessing ploidy status. These encompass the investigation of algorithms, refining image segmentation techniques, and discerning essential patterns throughout embryonic development. The purpose of the current study was to evaluate the effectiveness of using U-NET architecture for embryo segmentation and time-lapse embryo image sequence extraction, three and ten hr before biopsy to improve model accuracy for prediction of embryonic ploidy status.
Methods: A total of 1.020 time-lapse videos of blastocysts with known ploidy status were used to construct a convolutional neural network (CNN)-based model for ploidy detection. Sequential images of each blastocyst were extracted from the time-lapse videos over a period of three and ten hr prior to the biopsy, generating 31.642 and 99.324 blastocyst images, respectively. U-NET architecture was applied for blastocyst image segmentation before its implementation in CNN-based model development. 
Results: The accuracy of ploidy prediction model without applying the U-NET segment-ed sequential embryo images was 0.59 and 0.63 over a period of three and ten hr before biopsy, respectively. Improved model accuracy of 0.61 and 0.66 was achieved, respectively with the implementation of U-NET architecture for embryo segmentation on the current model. Extracting blastocyst images over a 10 hr period yields higher accuracy compared to a three-hr extraction period prior to biopsy.
Conclusion: Combined implementation of U-NET architecture for blastocyst image segmentation and the sequential compilation of ten hr of time-lapse blastocyst images could yield a CNN-based model with improved accuracy in predicting ploidy status.
Comparative Analysis of the Effects of Magnesium Oxide Nanoparticles on Sperm Parameters in Fresh and Frozen Samples
Authors: Bayat Sheida Mirgalooye , Farzaneh Farahnaz , Mirgaloybayat Shahla
Published: July 2024

Background: Freezing is a crucial technique in reproductive science utilized for the preservation of sperm samples. However, the process of freezing and thawing sperm can result in detrimental effects on sperm quality. One of the major mechanisms underlying this decline in sperm quality is the generation of reactive oxygen species   during the freeze process. The purpose of the current study was to investigate the effects of magnesium oxide nanoparticles   on frozen sperm parameters.
Methods: Semen samples were collected from 8 fertile men, aged 30 to 42 years, with normozoospermia, following 3 to 5 days of abstinence. The samples were divided into fresh (n=3), freeze (n=3), and control (n=2) groups. Three fresh experimental groups were only exposed to MgO NPs with concentrations of 5, 25, and 50 μg/ml and three freezing experimental groups were frozen after being treated with MgO NPs, thawed, and analyzed after 30 min.
Results: Our findings revealed that the progressive movement and vitality of sperm experienced a significant decline, while non-progressive and immotile sperm showed a notable increase in both fresh and frozen experimental groups exposed to MgO NPs. However, the application of MgO NPs during fresh and freezing processes demonstrated an effective preservation of pH, morphology, and DNA fragmentation in sperm cells.
Conclusion: The analysis revealed that MgO NPs negatively impact sperm motility and viability in both fresh and freeze analysis. Also, the use of MgO NPs in fresh and frozen processes effectively maintains the pH, morphology, and fragmentation of DNA in sperm cells.
The Image of Philosophy in Herman Melville’s Story Cock-A-Doodle-Do! or, the Crowing of the Noble Cock Beneventano
Authors: Menzhulin Vadym
Published: July 2024

The work of the outstanding American writer Herman Melville (1819–1891) is widely acknowledged for its profound philosophical depth. It parallels various philosophical and religious traditions, works, figures, ideas, etc. However, the author’s philosophical position remains insufficiently researched. Among his works, one key in this regard is the short story “Cock-A-Doodle-Do! or, The Crowing of the Noble Cock Beneventano” (1853). It offers Melville’s feedback on a few ideas of such representatives of American transcendentalism as Ralph Waldo Emerson (1803–1882) and Henry David Thoreau (1817–1862), with a particular focus on Thoreau’s analogy likening the purpose of philosophy to the crowing of a rooster. This story is almost completely unknown in Ukraine. Trying to reconstruct Melville’s view on Thoreau’s idea, the author recreates the context of creating “Cock-A-Doodle-Do!”, reviews available scholarly literature, and renders a technical translation of the narrative into Ukrainian. Throughout this process, the author provides commentary and clarifies its connection to ideas of Thoreau and Emerson, works by other authors, additional pieces by Melville, his biography, and related topics. The textual and intertextual analysis highlights the limitations of a common point of view whereby “Cock-A-Doodle-Do!” is only a piece of satire aimed exclusively at discrediting transcendentalism and the image of philosophy proposed by Thoreau. The author suggests that the story manifests Melville’s general attitude characteristic of his work overall and his philosophical method of philosophizing technique grounded in consistent skepticism towards any beliefs, convictions, and assertions, including those held by oneself. The systematic application of this method reveals universal ambivalence. Accordingly, Melville’s reflections on Thoreau’s idea of cockcrowing as a metaphor for philosophy reveal both critical and apologetic dimensions.
The Influence of Transformational Leadership, Work Competency, and Work Discipline on Work Productivity with Job Satisfaction as a Mediating Variable on Employees of the Aceh Human Resources Development Agency
Authors: Sari Rahma , Sulaiman  , Halimatussakdiah
Published: July 2024

This study investigates the correlation between transformational leadership, work competency, discipline, and work productivity at the Aceh Human Resources Development Agency (BPSDM Aceh) with job satisfaction as a moderating variable. Questionnaires were sent to 99 BPSDM Aceh workers as the main means of data collection in this research. The data analysis of this research made use of the Structural Equation Model Partial Least Square (SEM PLS). The SmartPLS software paradigm is employed to facilitate data processing for research objectives. The result shows that directly, transformational leadership and work competency do not significantly affect job satisfaction, while work discipline significantly affects job satisfaction; transformational leadership, work competency, and work discipline significantly affect work productivity, and; indirectly, transformational leadership and work competency does not significantly affect work productivity through mediation of job satisfaction, while work discipline significantly affects work productivity through mediation of job satisfaction. The results also show that job satisfaction functions as a partial mediation on the impact of work discipline on work productivity.
The Legal Liability of Subjects of Travel Activities (Tourist Services). Part Two
Authors: Kudrevatykh Aleksandr S. ,   Deputy Chairman of the Board of the National Association of Lawyers in Tourism, LL.M.
Published: July 2024

The article studies issues of the legal liability of subjects of tourist services. The author reviews liability bases and types, the practice of application of respective provisions and the arising law enforcement problems.
Factors of Criminalization of Minor Convicts
Authors: Kulakova Svetlana V. ,   Senior Research Scientist of the Research Institute of the Federal Penitentiary Service of Russia, PhD (Pedagogy), Tsvetkova Nadezhda A. ,   Chief Research Scientist of the Research Institute of the Federal Penitentiary Service of Russia, Doctor of Psychology
Published: July 2024

The article discusses the features and factors of criminalization of minors, analyzes the reasons for the involvement of adolescents in the criminal subculture. It also presents a generalized socio-psychological portrait of juvenile convicts serving sentences in educational colonies; The results of a study of risk factors, prevalence and specificity of elements of the criminal subculture (motives for acceptance, aspects of subordination to criminal leaders, etc.) among juvenile convicts are considered, and the directions of correctional and preventive work of penitentiary psychologists and other employees in this social group are shown.
Historical and Legal Fundamentals of Institutionalization of Jury Trials in Criminal Proceedings
Authors: Tutarinova Natalya N. ,   Teaching Assistant of the Department of Criminal Law of the Astrakhan State University, Attorney at the Astrakhan Regional Bar Association
Published: July 2024

The article is devoted to the study of the historical and legal foundations of the institutionalization of jury trials. The author defends the point of view that, being originally a British institution, starting from the second half of the 18th century, trial by jury began its wide and irreversible expansion on the European continent and beyond. Despite its supposedly “English” origin (if we take the Middle Ages as a basis), in fact, the institution of the jury has undergone a very long testing in Russia from 1864 to 1920, and this constitutional and legal model has undeniable advantages compared to the board of a professional judge and two people's assessors. This is mainly facilitated by the institutional separation of the procedural functions of professional justice and the participation of the people in the administration of justice in criminal cases.
Blockchain Technologies and the Judicial Procedure: New Challenges and Prospects
Authors: Melnik Viktor S. ,   Senior Major Case Investigator of the Chief Investigative Directorate for the North-Caucasian Federal District of the Investigative Committee
Published: July 2024

The article uses the example of judicial cases involving cryptocurrencies to review problems of the undefi ned status of cryptocurrencies in criminal and criminal procedure laws. The author notes the impact of blockchain technologies on processes of arrest and seizure of cryptocurrencies. The paper covers the problem of harmonization of Russian laws and international standards in this sphere. Potential solutions of existing problems are off ered.
The Effect of Environmental Message Framing on the Consumer Response and Perceived Risk of Zero-Waste Cosmetics
Authors: Park Eun-Hee , Lee In-Hee ,   The Korean Society of Beauty and Art
Published: July 2024

This study aimed to investigate how the framing of environmental messages affects consumer responses and perceptions of risks associated with zero-waste cosmetics. To achieve this goal, a questionnaire survey was conducted among Korean adult women aged 20 to 59 across the country, who had purchased zero-waste cosmetics between April 21 to 24, 2024. Out of 320 questionnaires distributed, 314 were utilized for the final analysis after excluding 6 poorly answered ones. The collected data underwent analysis through methods including frequency analysis, exploratory factor analysis, Cronbach’s alpha, t-tests, correlation analysis, and multiple regression analysis, using SPSS 25.0. The results revealed the following: First, in terms of consumer responses influenced by environmental message framing, there was a tendency for them to be more favorable when exposed to positive framing. Second, concerning risks perceived through environmental message framing, they tended to be higher when presented in negative framing. Third, regarding the influence of consumer responses on perceived risks, heightened intentions to seek additional information and a positive attitude towards advertising were associated with increased perceived risks. These findings are expected to offer valuable insights to the government, consumers, and businesses, facilitating tailored message framing strategies.
Meta-analysis of experimental studies of the effect of melatonin monotherapy on hemodynamic parameters in normotensive and hypertensive rats
Authors: Pliss M. G. , Kuzmenko N. V. , Tsyrlin V. A.
Published: July 2024

Objective. The purpose of the work is to use a meta-analysis to investigate the effect of melatonin monotherapy on the hemodynamic parameters of normotensive and hypertensive rats.

Design and methods. For our metaanalysis, we selected 39 publications, of which 28 studied the effect of melatonin monotherapy on hemodynamic parameters in normotensive rats, 12 in SHR rats, 7 in rats with fructose-induced hypertension, 3 in rats with L-NAME-induced hypertension. Meta-analysis of study results was conducted using the statistical program Review Manager 5.3 (Cochrane Library).

Results. Our meta-analysis showed that melatonin has a dose-dependent hypotensive and bradycardic effect with a single intravenous administration. The hypotensive effect of chronic administration of melatonin will increase with the duration of therapy. Moreover, the hypotensive effect of melatonin is significantly higher in hypertensive animals compared to normotensive ones. Long-term therapy with melatonin reduced blood pressure levels in normotensive animals by no more than 2 mm Hg, and in hypertensive rats by an average of 20–30 mm Hg.

Conclusions. As a result, since melatonin demonstrates a good hypotensive effect in various models of experimental hypertension, it is advisable to continue clinical studies of the possibility of using melatonin in the treatment of hypertension, which should focus on monotherapy, dose selection, various methods of increasing bioavailability and prolonging the effect.