bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Table 2 from Mechanisms of Resistance to Oncogenic KRAS Inhibition in Pancreatic Cancer
Authors: Dilly Julien , Hoffman Megan T. , Abbassi Laleh , Li Ziyue , Paradiso Francesca , Parent Brendan D. , Hennessey Connor J. , Jordan Alexander C. , Morgado Micaela , Dasgupta Shatavisha , Uribe Giselle A. , Yang Annan , Kapner Kevin S. , Hambitzer Felix P. , Qiang Li , Feng Hanrong , Geisberg Jacob , Wang Junning , Evans Kyle E. , Lyu Hengyu , Schalck Aislyn , Feng Ningping , Lopez Anastasia M. , Bristow Christopher A. , Kim Michael P. , Rajapakshe Kimal I. , Bahrambeigi Vahid , Roth Jennifer A. , Garg Kavita , Guerrero Paola A. , Stanger Ben Z. , Cristea Simona , Lowe Scott W. , Baslan Timour , Van Allen Eliezer M. , Mancias Joseph D. , Chan Emily , Anderson Abraham , Katlinskaya Yuliya V. , Shalek Alex K. , Hong David S. , Pant Shubham , Hallin Jill , Anderes Kenna , Olson Peter , Heffernan Timothy P. , Chugh Seema , Christensen James G. , Maitra Anirban , Wolpin Brian M. , Raghavan Srivatsan , Nowak Jonathan A. , Winter Peter S. , Dougan Stephanie K. , Aguirre Andrew J.
Published: November 2024

Characterization of acquired resistance to KRASG12C inhibition across studies and cancer types.
Supplementary Table 3 from T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study
Authors: Gainor Justin F. , Patel Manish R. , Weber Jeffrey S. , Gutierrez Martin , Bauman Julie E. , Clarke Jeffrey M. , Julian Ricklie , Scott Aaron J. , Geiger Jessica L. , Kirtane Kedar , Robert-Tissot Celine , Coder Brandon , Tasneem Moomal , Sun Jing , Zheng Wei , Gerbereux Lauren , Laino Andressa , Porichis Filippos , Pollard Jack Russella , Hou Peijie , Sehgal Vasudha , Chen Xing , Morrissey Manju , Daghestani Hikmat N. , Feldman Igor , Srinivasan Lakshmi , Frederick Joshua P. , Brown Michelle , Aanur Praveen , Meehan Robert , Burris Howard A.
Published: November 2024

Supplementary Table 3. Cellular markers used for post-expansion intracellular staining and identification of CD4 and CD8 responses.
Supplementary Figure 7 from T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study
Authors: Gainor Justin F. , Patel Manish R. , Weber Jeffrey S. , Gutierrez Martin , Bauman Julie E. , Clarke Jeffrey M. , Julian Ricklie , Scott Aaron J. , Geiger Jessica L. , Kirtane Kedar , Robert-Tissot Celine , Coder Brandon , Tasneem Moomal , Sun Jing , Zheng Wei , Gerbereux Lauren , Laino Andressa , Porichis Filippos , Pollard Jack Russella , Hou Peijie , Sehgal Vasudha , Chen Xing , Morrissey Manju , Daghestani Hikmat N. , Feldman Igor , Srinivasan Lakshmi , Frederick Joshua P. , Brown Michelle , Aanur Praveen , Meehan Robert , Burris Howard A.
Published: November 2024

Supplementary Figure 7. Distribution of T cell subsets pre-treatment and post-treatment for high (Patients 7 and 6) and low (Patients 13 and 14) immune responders.
Peptide list and HLA types from T-cell Responses to Individualized Neoantigen Therapy mRNA-4157 (V940) Alone or in Combination with Pembrolizumab in the Phase 1 KEYNOTE-603 Study
Authors: Gainor Justin F. , Patel Manish R. , Weber Jeffrey S. , Gutierrez Martin , Bauman Julie E. , Clarke Jeffrey M. , Julian Ricklie , Scott Aaron J. , Geiger Jessica L. , Kirtane Kedar , Robert-Tissot Celine , Coder Brandon , Tasneem Moomal , Sun Jing , Zheng Wei , Gerbereux Lauren , Laino Andressa , Porichis Filippos , Pollard Jack Russella , Hou Peijie , Sehgal Vasudha , Chen Xing , Morrissey Manju , Daghestani Hikmat N. , Feldman Igor , Srinivasan Lakshmi , Frederick Joshua P. , Brown Michelle , Aanur Praveen , Meehan Robert , Burris Howard A.
Published: November 2024

Peptide list and HLA types.
Supplementary Figure S1 from Mechanisms of Response and Tolerance to Active RAS Inhibition in KRAS-Mutant Non–Small Cell Lung Cancer
Authors: Araujo Haniel A. , Pechuan-Jorge Ximo , Zhou Teng , Do Minh Truong , Hu Xin , Rojas Alvarez Frank R. , Salvatierra Maria E. , Ibarguen Heladio P. , Lee Richard , Raghulan Rashi , Shah Harshit , Moreno Ayala Mariela A. , Chen Kevin , Tovbis Shifrin Nataliya , Wu Shuhong , Solis Soto Luisa M. , Negrao Marcelo V. , Gibbons Don L. , Hong David S. , Roth Jack A. , Heymach John V. , Zhang Jianjun , Jiang Jingjing , Singh Mallika , Smith Jacqueline A.M. , Quintana Elsa , Skoulidis Ferdinandos
Published: November 2024

Supplementary Figure S1. Activity of RAS inhibitors in immune-competent pre-clinical models of KRASG12C-mutated NSCLC.
Supplementary Methods from A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer
Authors: Singhal Anupriya , Styers Hannah C. , Rub Jonathan , Li Zhuxuan , Torborg Stefan R. , Kim Jung Yun , Grbovic-Huezo Olivera , Feng Huijin , Tarcan Zeynep Cagla , Sahin Ozkan Hulya , Hallin Jill , Basturk Olca , Yaeger Rona , Christensen James G. , Betel Doron , Yan Yan , Chio Iok In Christine , de Stanchina Elisa , Tammela Tuomas
Published: November 2024

Supplementary Methods includes additional detailed experimental methodology and description of computational analyses.
Supplementary Figures 1-6 from A Classical Epithelial State Drives Acute Resistance to KRAS Inhibition in Pancreatic Cancer
Authors: Singhal Anupriya , Styers Hannah C. , Rub Jonathan , Li Zhuxuan , Torborg Stefan R. , Kim Jung Yun , Grbovic-Huezo Olivera , Feng Huijin , Tarcan Zeynep Cagla , Sahin Ozkan Hulya , Hallin Jill , Basturk Olca , Yaeger Rona , Christensen James G. , Betel Doron , Yan Yan , Chio Iok In Christine , de Stanchina Elisa , Tammela Tuomas
Published: November 2024

Supplementary Figure 1. KRAS inhibition promotes a classical differentiation state in mouse models of PDAC. Supplementary Figure 2. Gene expression analyses of KPF PDAC cells upon KRAS inhibition. Supplementary Figure 3. Generation and validation of a genetic reporter model to study classical cancer state dynamics in vivo. Supplementary Figure 4. In vivo dynamics of the classical state utilizing a distinct genetic reporter model. Supplementary Figure 5. Classical PDAC cells drive resistance to KRAS inhibition upon spontaneous tumor relapse. Supplementary Figure 6. KRAS inhibition promotes a classical cancer cell state in human PDAC.
Supplementary Table 3 from A Call for Innovative Translational and Clinical Research to Address China’s Unique Cancer Landscape
Authors: Zhang Chaoqi , Wu Peng , Li Dongyu , Gu Xuanyu , Lin Chuqi , Zhou Junhan , Shang Dexin , Liu Jingjing , Ma Ruijie , Zhao Bohui , Sun Nan , He Jie
Published: November 2024

Supplementary Table 3. The detailed information obtained from Pharmcube regarding the total number of first-in-class (FIC) anti-cancer agents.
Supplementary Table 2 from A Call for Innovative Translational and Clinical Research to Address China’s Unique Cancer Landscape
Authors: Zhang Chaoqi , Wu Peng , Li Dongyu , Gu Xuanyu , Lin Chuqi , Zhou Junhan , Shang Dexin , Liu Jingjing , Ma Ruijie , Zhao Bohui , Sun Nan , He Jie
Published: November 2024

Supplementary Table 2. The number of clinical trials evaluating Chinese anti-cancer agents stratified by different phases from 2018-2023.
Highly Multiplexed Tissue Imaging in Precision Oncology and Translational Cancer Research
Authors: Bollhagen Alina , Bodenmiller Bernd
Published: November 2024

Precision oncology tailors treatment strategies to a patient’s molecular and health data. Despite the essential clinical value of current diagnostic methods, hematoxylin and eosin morphology, immunohistochemistry, and gene panel sequencing offer an incomplete characterization. In contrast, highly multiplexed tissue imaging allows spatial analysis of dozens of markers at single-cell resolution enabling analysis of complex tumor ecosystems; thereby it has the potential to advance our understanding of cancer biology and supports drug development, biomarker discovery, and patient stratification. We describe available highly multiplexed imaging modalities, discuss their advantages and disadvantages for clinical use, and potential paths to implement these into clinical practice.

Significance: This review provides guidance on how high-resolution, multiplexed tissue imaging of patient samples can be integrated into clinical workflows. It systematically compares existing and emerging technologies and outlines potential applications in the field of precision oncology, thereby bridging the ever-evolving landscape of cancer research with practical implementation possibilities of highly multiplexed tissue imaging into routine clinical practice.
Early Cancer Detection Through Comprehensive Mapping of Dynamic Tumorigenesis
Authors: Chang Jiang , Zheng Tongsen , Wu Chen
Published: November 2024

Current strategies for early cancer detection and diagnosis need updating to achieve greater precision, necessitating the creation of a comprehensive evolutionary map of tumorigenesis. This requires establishing high-quality prospective cohorts, systematically collecting samples for integrated spatiotemporal multiomics analyses, and efficiently translating laboratory findings into clinical applications.
Targeting Noncoding cis-Regulatory Elements for Cancer Therapy in the Context of the 3D Genome
Authors: Li Kailong , Wei Gong-Hong , Yin Yuxin , Feng Jiawen
Published: November 2024

Significant efforts have been made to identify and validate oncoproteins and ncRNAs as therapeutic targets for cancer therapy; however, emerging observations suggest that noncoding cis-regulatory elements, which orchestrate the 3D organization of the genome and thus the transcriptional landscape, are potential therapeutic targets as well. In this commentary, we envisage that further efforts to decipher the noncoding cis-regulatory code and performing systematic surveys of functional noncoding cis-regulatory elements and recurrent 3D genome alterations in both cancerous and nonmalignant cells within tumor tissues will pave the way to the development of novel therapeutic strategies.
A Call for Innovative Translational and Clinical Research to Address China’s Unique Cancer Landscape
Authors: Zhang Chaoqi , Wu Peng , Li Dongyu , Gu Xuanyu , Lin Chuqi , Zhou Junhan , Shang Dexin , Liu Jingjing , Ma Ruijie , Zhao Bohui , Sun Nan , He Jie
Published: November 2024

The Chinese government has, in recent decades, implemented various administrative laws and regulatory policies to expedite cancer therapeutic development, boosting research and development pipelines for domestic pharmaceutical companies and clinical trials; however, China faces unique challenges given the high prevalence of certain cancer types and distinct disease burdens, some of which are frequently overlooked by international pharmaceutical companies. Given the substantial unmet need for China-specific cancer care, it is crucial to promote the development of innovative pharmaceutical and clinical research in China, with a particular emphasis on addressing tumors most prevalent in its population.
Combination Diagnostics: Adding Blood-Based ctDNA Screening to Low-Dose CT Imaging for Early Detection of Lung Cancer
Authors: Haber Daniel A. , Skates Steven J.
Published: November 2024

Annual low-dose CT screening of individuals with a smoking history identifies early curable lung tumors and reduces cancer mortality by 20%, yet only a minority of eligible patients undergo such monitoring. Mazzone and colleagues apply a blood-based cfDNA fragmentomic assay as a high-sensitivity/low-specificity pre-screen to help stratify individuals who may benefit most from more definitive low-dose CT imaging.

See related article by Mazzone et al., p. 2224
Supplementary Table 2 from Therapy-Related Myeloid Neoplasms: Complex Interactions among Cytotoxic Therapies, Genetic Factors, and Aberrant Microenvironment
Authors: Singhal Deepak , Kutyna Monika M. , Hahn Christopher N. , Shah Mithun Vinod , Hiwase Devendra K.
Published: November 2024

Supplementary Table 2 shows comparative frequency of cytogenetic abnomalities. (A) p-MN and t-MN; (B) p-MDS and t-MN stratified according to IPSS-R; (C) p-AML and t-AML stratified according to MRC/ELN.
Suppl. Fig. 8 from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Co-segregation of mitochondrial and somatic nuclear DNA mutations in CLL.
Suppl. Fig. 6 from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Limit of detection of mitochondrial DNA mutations extracted from bulk RNA-seq data.
Suppl. Fig. 14 from Tracking Rare Single Donor and Recipient Immune and Leukemia Cells after Allogeneic Hematopoietic Cell Transplantation Using Mitochondrial DNA Mutations
Authors: Penter Livius , Cieri Nicoletta , Maurer Katie , Kwok Marwan , Lyu Haoxiang , Lu Wesley S. , Oliveira Giacomo , Gohil Satyen H. , Leshchiner Ignaty , Lareau Caleb A. , Ludwig Leif S. , Neuberg Donna S. , Kim Haesook T. , Li Shuqiang , Bullinger Lars , Ritz Jerome , Getz Gad , Garcia Jacqueline S. , Soiffer Robert J. , Livak Kenneth J. , Wu Catherine J.
Published: November 2024

Identification of cell types and tracking of mitochondrial DNA mutations in immunosuppression tapering (IST) cohort using ASAP-seq.
Supplementary Figure 1 from Multiple Myeloma Risk and Outcomes Are Associated with Pathogenic Germline Variants in DNA Repair Genes
Authors: Thibaud Santiago , Subaran Ryan L. , Newman Scott , Lagana Alessandro , Melnekoff David T. , Bodnar Saoirse , Ram Meghana , Soens Zachry , Genthe William , Brander Tehilla , Mouhieddine Tarek H. , Van Oekelen Oliver , Houldsworth Jane , Cho Hearn Jay , Richard Shambavi , Richter Joshua , Rodriguez Cesar , Rossi Adriana , Sanchez Larysa , Chari Ajai , Moshier Erin , Jagannath Sundar , Parekh Samir , Onel Kenan
Published: November 2024

SUPPLEMENTARY FIGURE 1: Output of Cox Proportional Hazards Model for Multivariate PFS1 Analysis in HDM-ASCT Recipients with MM (Combined Cohort)
Supplementary Table S6 from Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non–Small Cell Lung Cancer
Authors: Hayashi Hidetoshi , Nishio Makoto , Akamatsu Hiroaki , Goto Yasushi , Miura Satoru , Gemma Akihiko , Yoshino Ichiro , Misumi Toshihiro , Kijima Takashi , Takase Naoto , Fujita Masaki , Tasaka Sadatomo , Mouri Atsuto , Kondo Tetsuro , Takamura Kei , Kawashima Yosuke , Imaizumi Kazuyoshi , Iwasawa Shunichiro , Nakagawa Shintaro , Mitsudomi Tetsuya
Published: November 2024

Supplementary Table S6. Association between skin or endocrine disorder irAEs and predictors of ICI effect a Mann–Whitney U Test. b Patients who had progression within 4 or 6 weeks after the initiation of treatment were excluded. Abbreviations: CRP, C-reactive protein; ICI, immune checkpoint inhibitor; IHC, immunohistochemical; irAE, immune-related adverse event; NLR, neutrophil-to-lymphocyte ratio; PD-L1, programmed death ligand-1; Q, quartile; SD, standard deviation.
Sequence of events leading to medical abortion for fetal indications after 34 weeks’ gestation: 23 years of experience in a single medical center
Authors: Pekar Zlotin1 Marina , Nehama Berman Yael , Melcer Yaacov , Cuckle Howard , Maymon Ron
Published: November 2024

Introduction: Technical advances are rapidly improving the ability to detect anatomical malformations and genetic abnormalities during pregnancy. We aimed to identify the sequence of events leading to medical abortion ≥ 34 weeks’ gestation, to determine whether the procedure could have been carried out earlier.
Method: Retrospective study of medical abortions in singleton pregnancies carried out in our department over a 23-year period from1998 to 2021.
Results: 36/4055 (0.88%) abortions were carried out ≥ 34 weeks’ gestation. The indications were anatomical in 20 (55%), chromosomal or genetic in 14 (39%) and CMV infection In two. Evaluation of the sequence of events suggests that an earlier diagnosis would have been unfeasible before the third trimester in 18 cases (50%) because the disorder was developmental and ultrasound findings would not have presented earlier. By contrast, certain other cases might have been diagnosed earlier if the patient had not delayed routine screening or if screening had been administered on schedule.
Conclusion: In this series, full adherence to local screening tests and protocols, and timely decision-making could have substantially reduced the late abortion rate by as much as half.
Prophetic values in the leadership of Muhammadiyah Yogyakarta school
Authors: Dewantoro Mohammad Hajar , Susilo Mohamad Joko
Published: November 2024

Rasulullah SAW was successful in becoming a uswatun hasanah (good leader and role model). This field research aims to determine the prophetic values in leadership of Yogyakarta Muhammadiyah schools and percentage of their implementation. Research was carried out with a purposive technique in primary and secondary education Muhamamdiyah schools in Yogyakarta, with the subject being the principal. The data collection techniques used questionnaires, interviews, and documentation, while the data analysis technique was carried out descriptively qualitatively. The results showed that prophetic values in Muhammadiyah school leadership in Yogyakarta found four main values that exist in all Muhammadiyah schools: i) adopting a collegial collective leadership system; ii) based on faith; iii) oriented towards the quality of progressing schools; and iv) applying ta'awun (cooperation). The highest percentage of implementation of prophetic values based on 3 aspects (humanization, liberation, and transcendence) was found at Muhammadiyah Elementary School Condongcatur and Muhammadiyah Vocational School Pakem at 92.9%.
Students need analysis in developing mobile English application for English as a foreign language young learner
Authors: Fansury Andi Hamzah , Rahman Ali Wira , Rampeng Rampeng , Hamsiah Andi
Published: November 2024

Technology in the learning process can assist in providing teaching materials to students, making it easier for students, teachers, and parents to react whenever and wherever they are; facilitate and assist in the preparation of materials sourced from the internet; as well as assist in simulating, visualizing the learning process in a structured, processed, and scientific manner. This research analyzed the student's need to develop the mobile application. This research used the steps in the combined research and development (RD) and analysis, design, develop, implement, and evaluate (ADDIE) models. The study was conducted in Makassar, and the research subject was the students at Junior High School, with 100 randomly selected participants. The data were analyzed descriptively using interviews, observations, and participant questionnaires. The result showed that students need applications containing material that is easier to understand, using audio or video using Indonesian speakers, and interactive exercises so the students can improve their speaking skills. Based on the results of the questionnaire, the researcher synergized the school's existing curriculum with the needs analysis (N.A.) carried out by the researcher so that the results of this study would benefit the English as a foreign language (EFL) young learners, teachers, and stakeholders.
Navigating the river of knowledge: two decades of unraveling global trends in adolescent well-being research
Authors: Jafar Mohd Fairuz , Aziz Muhammad Noor Abdul , Kasim Marini , Yanti Prima Gusti , Asni Asni , Puspitasari Nuraini , Purwanto Sigid Edy
Published: November 2024

This study examines the global issue of adolescent well-being by conducting a bibliometric analysis of 1,162 publications from the Scopus database, covering the period from 2003 to March 2023. The research aims to identify the most influential contributors, including countries, authors, journals, and key topics, within the field of adolescent well-being. The findings reveal that the USA, the UK, and Italy are the most active countries in this area of research, indicating their strong focus on adolescent well-being issues. Leading authors such as Landsverks and Barth are recognized as highly influential contributors to the field, with their work being frequently cited. The study also highlights prominent academic journals, including Children and Youth Services Review, Child Abuse and Neglect, and Journal of Youth and Adolescence, which have emerged as key platforms for disseminating research on adolescent well-being. These journals have played a crucial role in shaping academic discourse, as evidenced by their high citation counts. In terms of research topics, the analysis identifies major themes such as contributing factors to adolescent well-being and interventions aimed at improving it. These topics have been the focus of extensive research, reflecting the global concern for understanding and addressing the challenges faced by adolescents. The study provides a detailed overview of the current trends in research on adolescent well-being, offering valuable insights for future studies. Overall, the findings contribute to the growing body of literature in this area and underscore the importance of continued research on adolescent well-being at a global level.
The effectiveness of the student teams' achievement divisions in social studies learning on activeness and learning outcomes
Authors: Fikri Asyrul , Saputra Cheri , Boty Middya , Rico Muhammad , Ilmiawan Ilmiawan , Assidiqi Muadz , Setiawan Johan
Published: November 2024

Student teams’ achievement divisions (STAD) is a learning method that can provide active responses to students so that learning is maximized, but this method is still very rarely used by social studies teachers, thus making social studies learning less than optimal. The purpose of this study is to analyze the effectiveness of the question students have method in social studies learning to increase student activity and learning outcomes. The procedure divides two class groups experimental and control using a quasi-experimental nonequivalent control group design. A sample of 122 seventh-grade kids from a junior high school in Yogyakarta was utilized as the population. While instruments, interviews, and observations were employed in the data collecting process, cluster random sampling was the sampling strategy. An N-gain score test and an independent sample T-test were utilized in the data analysis. The findings demonstrated that, when compared to traditional classroom settings, the STAD's social studies teaching methodology was able to improve student engagement and learning outcomes. The N-gain score test was classified as medium, and the independent sample T-test yielded a significance value of 0.0000.05. Thus, the STAD approach has a huge influence, which makes.
Kuhnian perspectives in science education: a comparative review of proponents and skeptics
Authors: Perrmansah Sigit , Rahman Abdul , Rusmana Dede , Indrawati Cicilia Dyah Sulistyaningrum
Published: November 2024

Despite the abundance of literature discussing Kuhnian views, it is rare to find studies that comprehensively compare the arguments of Kuhnian supporters and skeptics. This study aims to fill the gap by providing a comparative review and synthesis between the two groups of views using the systematic literature review (SLR) analysis technique. The researcher found 1,413 articles reduced with the standard prism protocol to 32 articles that examined Kuhn's views. Proponents support the existence of Kuhn's scientific paradigm where they not only strengthen and consider the importance of Kuhn's theory, but also expand its application to various fields, showing the flexibility and relevance of the theory in understanding the scientific revolution that occurred in various disciplines. Skeptics criticize Kuhn's views such as the ambiguity of the term "paradigm", the non-recognition of scientific revolutions that lead to scientific evolution, and the doubt of the concept of incommensurability in various disciplines. This shows that Thomas Kuhn made a great contribution to the world of scientific education because it can provoke experts to study his thoughts for the benefit of science. The findings of this study are expected to contribute to policy makers and other researchers in applying and studying Kuhn's paradigm.
Practice and reflection of differentiated learning in sociology at senior high school
Authors: Hati Kusuma , Rahmayanti Ayu Afriliani , Aprilia Cinta Widi Happy , An Nisa Luthfiyah , Anggraeni Meisita , Trinugraha Yosafat Hermawan , Parahita Bagas Narendra
Published: November 2024

Global challenges require the government to organize learning in schools that are more up-to-date following episodes in the times. The independent curriculum learning promises flexibility for teachers and students and replaces the relatively new curriculum-13. In implementing the independent curriculum, differentiated learning is a concept that focuses on the diversity of students’ learning styles. This research was conducted to obtain an overview of the implementation and reflection of differentiated learning in senior high schools in Central Java. Teachers, especially those teaching sociology subjects, the assistant principal of academic affairs and curriculum, and students are the research subjects. It is qualitative research with a phenomenological research type and purposive sampling technique. The results of this study show: i) the practice of differentiated learning in sociology subjects in high schools has been well implemented with the independent curriculum approach; ii) the challenges and obstacles faced by sociology teachers when implementing differentiated learning are the teacher’s skills in preparing learning; and iii) sociology teachers who face challenges and obstacles when implementing differentiated learning must pay more attention to the readiness of differentiated skills.
Gamification as an alternative to increase students’ motivation: a scoping review
Authors: Rahmi Iftita , Rimenda Tetty , Ariyanti Tika Dwi
Published: November 2024

Gamification is the process of adding game-like features and mechanics in non-game contexts, such as learning, training, or marketing, to make them more engaging, enjoyable, and effective. This scoping review aims to investigate the impact of gamification on student motivation and identify the most frequently used and effective elements of gamification in educational contexts. A systematic search was conducted using five databases: Emerald, Scopus, Sage, Garuda, and Google Scholar. The preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) guidelines were followed. The review included 25 articles that met the inclusion criteria. The findings suggest that gamification can positively influence student motivation and engagement. However, the effectiveness of gamification elements varies across different contexts and learners. Points, levels, and leaderboards are among the most commonly used elements, but their impact on intrinsic motivation remains debatable. The review highlights the need for further research to understand the specific factors that contribute to the success or failure of gamification in education. The insights gained from this review can serve as a foundation for developing effective gamification-based educational materials that cater to the diverse needs of learners and foster their motivation to learn.
Integrating Maja Labo Dahu culture in Islamic education: a module for character development in elementary students
Authors: Umar Umar , Ghufron Anik , Wuryandani Wuri
Published: November 2024

This study aims to measure the development of Islamic education modules integrated with Maja Labo Dahu culture that can improve the character of elementary school students. Module development was conducted at State Elementary School 45 Pane, Bima City, using the Borg and Gall model development research (RD) method. The results of the product validity test of the Maja Labo Dahu culture-integrated Islamic education module showed a score of 3.60, which was included in the very feasible criteria. Based on the results of the small group, limited-scale trial consisting of 20 students of State Elementary School 45 Pane, Bima City with a sample of 18 grade V students, it shows the effectiveness of improving student character in learning activities using Islamic education modules integrated with Maja Labo Dahu culture. The results of the data analysis of student character observations are also in the good category, with an average value of 3.33. We know that 50% of students meet the good attitude criteria. Thus, the development of Islamic education teaching modules integrated with Maja Labo Dahu culture has a positive impact on improving the character values of elementary school students.
Mapping chemistry learning difficulties of secondary school students: a cross-grade study
Authors: Pratomo Heru , Fitriyana Nur , Wiyarsi Antuni , Marfuatun Marfuatun
Published: November 2024

Students' lack of interest in chemistry becomes a significant issue in chemistry learning. This may be caused by the negative perception of students about their difficulties in learning chemistry. This study aims to explore views and causes of difficulties in learning chemistry from the perspective of secondary school students. This research was designed using a survey method through a cross-grade study. The sample that participated in this study was 634 students from the Grade 10, 11, and 12 (G10, G11, and G12) of secondary school students in Yogyakarta, Indonesia, through random sampling. The data in this study were collected using the chemistry difficulties scale (CDS) and chemistry perception questions (CPQ). Statistical descriptive techniques, a one-way multivariate analysis of variance (MANOVA) test, and content analysis, were used to analyse the research data. The results showed that the grade somewhat affected students' views towards chemistry. They viewed chemistry as a fairly difficult subject, with stoichiometry, thermochemistry, and macromolecule being among the most challenging topics in G10, G11, and G12, respectively. These difficulties are caused by scientific language, mathematical abilities, student abilities, and teacher competence in conducting chemistry lessons. Since the students consider chemistry somewhat difficult, chemistry teachers must take appropriate strategies to overcome these difficulties.
Transformative leadership: cultivating teacher excellence through satisfaction, environment, and self-efficacy
Authors: Virgana Virgana , Fitriani Ade
Published: November 2024

Enhancing teacher performance (TP) in secondary education hinges on robust support in leadership, self-efficacy (SE), environment, and job satisfaction (JS). This article investigates how leadership influences TP, examining its intricate connection with JS, work environment, and SE. The study, encompassing 400 teachers, utilizes quantitative survey data subjected to exploratory factor analysis (EFA) for instruments. The data underwent path analysis employing Smart Partial Least Squares software, meeting the criterion of p0.70 for validation. Key findings demonstrate that transformational leadership, SE, and the work environment significantly influence JS. Moreover, in conjunction with JS, these factors positively impact TP. Notably, SE and an inspiring work environment indirectly enhance performance through their influence on JS. In summary, this research underscores the pivotal role of transformational leadership in TP enhancement. Transformational leaders can establish an empowering context for teachers to deliver high-quality education by prioritizing JS, the work environment, and SE. This underscores the necessity for educational institutions to emphasize administrator training in transformational leadership, thereby fostering a culture that values and supports effective leadership practices. Implications for further research suggest that transformational leadership improves TP and highlights avenues for additional exploration and application within educational contexts.
4C skills teaching activities for mathematics teachers: application of modified nominal group technique
Authors: Zakaria Mohamad Ikram , Hanri Chuzairy , Noer Sri Hastuti , Triana Mella , Widyastuti Widyastuti
Published: November 2024

Education 4.0 strongly promotes the development of communication, collaboration, critical thinking, and creativity (4C) skills among students. Consequently, it is crucial for mathematics teachers to integrate activities that facilitate the cultivation of these skills. However, the scarcity of resources, such as recommended instructional activities, poses a challenge for mathematics teachers striving to effectively impart 4C skills through problem-solving methods. This research aims to develop a set of teaching activities designed to enhance the delivery of 4C skills through problem-solving methods, thereby supporting mathematics teachers in improving their pedagogical strategies. Utilizing the modified nominal group technique (mNGT), the study engaged 11 experts from diverse fields, including mathematics education, pedagogy, curriculum development, and primary and secondary education. Data collection was conducted through expert discussions between January 2024 and February 2024. Descriptive statistics (percentages) were employed to analyze the data, prioritizing and ranking each teaching activity. The findings identified 19 pertinent teaching activities that emphasize 4C skills through problem-solving methods. The highest-ranked activity was motivating students to explore various learning resources, including information and communication technology (ICT) tools (98%), while guiding students through problem-solving questions received the lowest ranking (75%). In conclusion, the comprehensive list of teaching activities provides a valuable guide for mathematics teachers to effectively incorporate 4C skills into their instructional practices.
МАРКЕТИНГОВІ ПОСЛУГИ: АНАЛІЗ ВИКЛИКІВ І МОЖЛИВОСТЕЙ
Authors: Трущенкова Л. В. , Шевчук Л. В.
Published: November 2024

Мета: проаналізувати основні виклики, які постають перед маркетинговими стратегіями в умовах війни, а саме проблеми з комунікацією, доступністю ресурсів, змінами в соціальному середовищі та впливом на громадське сприйняття. Виявити нові можливості, які зʼявляються для маркетингових послуг у сфері громадського здоровʼя в умовах кризи. Розглянути інноваційні підходи до комунікації і можливості для покращення громадської обізнаності та залучення спільноти.
Матеріали і методи. Проведено аналіз транстеоретичної моделі поведінки. Використано метод контент-аналізу, структурно-логічного аналізу.
Результати. Розглянуто пʼять стадій змін, такі як: підготовка (Precontemplation), розгляд (Contemplation), готовність (Preparation), дія (Action), підтримка (Maintenance). Описано та обґрунтовано значення кожної стадії. Розроблено специфічні інтервенції на основі транстеоретичної моделі поведінки, що враховують унікальні умови війни.
Висновки. Транстеоретична модель поведінки може бути корисною для розробки стратегій зміни поведінки в Україні в умовах війни. Однак адаптація моделі до специфічних умов конфлікту є критично важливою для забезпечення її ефективності. Необхідно враховувати виклики, такі як психологічний стрес, нестабільність ресурсів та обмеження доступу до послуг, і застосовувати інноваційні підходи для підтримки змін поведінки. Один з основних викликів – це обмеження доступу до ресурсів і дезінформація, що ускладнює реалізацію маркетингових кампаній у сфері громадського здоровʼя. Важливо впроваджувати стратегії, які дозволяють оперативно реагувати на зміну ситуації та забезпечувати актуальність інформації.
Evolvability in Artificial Development of Large, Complex Structures and the Principle of Terminal Addition
Authors: Fontana Alessandro , Wróbel Borys
Published: November 2024

Epigenetic tracking (ET) is a model of development that is capable of generating diverse, arbitrary, complex three-dimensional cellular structures starting from a single cell. The generated structures have a level of complexity (in terms of the number of cells) comparable to multicellular biological organisms. In this article, we investigate the evolvability of the development of a complex structure inspired by the “French flag” problem: an “Italian Anubis” (a three-dimensional, doglike figure patterned in three colors). Genes during development are triggered in ET at specific developmental stages, and the fitness of individuals during simulated evolution is calculated after a certain stage. When this evaluation stage was allowed to evolve, genes that were triggered at later stages of development tended to be incorporated into the genome later during evolutionary runs. This suggests the emergence of the property of terminal addition in this system. When the principle of terminal addition was explicitly incorporated into ET, and was the sole mechanism for introducing morphological innovation, evolvability improved markedly, leading to the development of structures much more closely approximating the target at a much lower computational cost.
Attentional Refreshing in Working Memory and Its Interplay with Long-term Memory: A Behavioral and Electroencephalographic Study
Authors: Labaronne Maximilien , Caclin Anne , Plancher Gaën
Published: November 2024

Despite the growing interest in the study of attentional refreshing, the functioning of this working memory maintenance mechanism, including its cerebral underpinnings, is still debated. In particular, it remains unclear whether refreshing promotes long-term memory and whether it, in return, depends on long-term memory content to operate. Here, we used direct maintenance instructions and measured brain activity to investigate working memory maintenance with two objectives: (1) test if different behavioral and oscillatory patterns could be observed when participants were instructed to use attentional refreshing versus verbal rehearsal, and (2) observe whether and how refreshing is modulated when maintaining novel (pseudowords) versus familiar (words) memoranda. We conducted an EEG experiment using a modified Brown-Peterson task, in which we manipulated the type of maintenance engaged through explicit instructions (verbal rehearsal vs. refreshing), the type of memoranda (words vs. pseudowords), and the memory load (2 vs. 6). Using scalp EEG, we measured both neural oscillations during working memory maintenance and ERPs during the concurrent parity judgment task. For words, we showed that verbal rehearsal benefited more short-term recall whereas refreshing benefited more delayed recall. In keeping with these behavioral differences between maintenance instructions, frontal–midline theta power increased with memory load only when using verbal rehearsal, whereas occipito-parietal alpha desynchronization was larger with refreshing than verbal rehearsal. When maintaining pseudowords, verbal rehearsal also benefitted short-term recall more than refreshing. However, no long-term memory benefit of refreshing was observed for pseudowords, and oscillatory activity was not different under the two maintenance instructions. Our results provide new evidence supporting the independence between attentional refreshing and verbal rehearsal, and bring new insight into refreshing functioning. We discuss the possible interpretations of these results and the implications for the attentional refreshing literature.
Finger Tapping as a Behavioral Indicator of Presence in VR
Authors: Hinkle Sean , Soares Shayna , Bohil Corey
Published: November 2024

The sense of spatial presence in virtual environments (VEs) is typically measured using self-report methods after task completion. Recent years have seen efforts to measure presence via physiological markers, with mixed results. Behavioral indicators might better track variations in presence over time. We propose finger tapping as an indicator of changing attentional demands corresponding to low and high presence conditions in VEs. Participants completed “virtual plank” (raised vs lowered to reflect high or low presence) and VR video (90° vs 360°) conditions while attempting to tap their fingers at a specified rate. Participants wore a data glove to measure finger taps, and we analyzed variations in the inter-tap intervals. We trained a neural net classifier to distinguish between low and high presence conditions using features derived from the positional finger-tap timeseries (e.g., power spectral density, autocorrelation). The trained network classified test epochs with a success rate of 80% for both video and plank conditions.
Make it a standard? The creation and variability assessment of a consensus standard protocol for Tenebrio molitor larvae feeding trials
Authors: Deruytter D. , Rumbos C.I. , Adamaki-Sotiraki C. , Tournier L. , Ageorges V. , Coudron C.L. , Yakti W. , Ulrichs C. , Spranghers T. , Berrens S. , Van Peer M. , Bellezza Oddon S. , Biasato I. , Resconi A. , Paris N. , Hotte N. , Hénault-Ethier L. , Gasco L. , Athanassiou C.G.
Published: November 2024

Interest in the nutrition of the yellow mealworm (Tenebrio molitor L.) larvae is on the rise, leading to an increase in publications on this topic. The absence of a standard protocol and resulting differences in experimental designs reduces comparability among studies and impedes research on mealworm nutrition. To address this, a consensus standardised protocol was developed specifically for the evaluation of mealworm larval growth and performance in feeding trials. The efficacy of this protocol was evaluated through an international ring test involving seven partners using two wheat brans as dry feed (a standard bran and a local bran) at 27 °C and 60% relative humidity. As experimental units, plastic crates filled with 2.1 kg of bran and 10,000 4-week-old larvae were used with six replicates. Agar gel was provided as wet feed ad libitum. The mean individual larval weight and the number of larvae per crate were determined weekly until either three or more replicates ran out of feed or pupation exceeded 10%. At harvest, the total larval fresh biomass and amount of frass was determined. Larval samples were taken for chemical analysis. To assess the protocol, the within (repeatability) and between (reproducibility) laboratory variability was calculated for each parameter. The repeatability was good (limit at 12% (standard) and 14% (local)). The reproducibility was poorer with a limit 2.7 times higher for the standard feed (36%) and 3.8 times higher for the local feed (55%). For both feeds, the total larval fresh harvest, amount of frass and the larval protein concentration were the most consistent both within and among laboratories. The highest variability was observed at the early life stages and for the larvae ash content. The detailed consensus standard protocol and repeatability/reproducibility estimates can be used as basis for future mealworm feeding trials, comparing results and future improvements.
A Novel Switch-Coupled Inductor High Gain Quadratic Converter with Low Input Current Ripple
Authors: Zhu Gao-Zhong , Wang Bin
Published: November 2024

In order to reduce the ripple of input current at the input and increase the output voltage of the converter, a new switch coupled-inductor high-gain converter is proposed. The principle of operation of the proposed new switch coupled-inductor converter is analyzed. According to the
influence of L1 and L2 in the switch coupledinductor unit on the working state, the inductors L1 and L2 are divided into three cases: L1 = L2, L1 > L2,
L1 < L2, the expressions of voltage gain ratio and coupling input inductor current ripple of the converter under three conditions are derived. By comparing with the original quadratic converter, it is concluded that the proposed magnetic integrated converter
reduces the ripple of input current, while increasing the voltage gain, and summarizes the best working conditions of inductors L1 and L2. Finally, the outstanding characteristics of the proposed converter have been confirmed by simulation and experiment.
Improved Finger Vein Recognition Using Generative Adversarial Network and Transfer Learning
Authors: Mathew Amitha , Amudha P.
Published: November 2024

The unique and secure nature of Finger Vein Recognition (FVR) has attracted considerable attention in the field of biometric authentication. However, challenges such as limited data availability and the complexity of vein patterns necessitate innovative approaches to improve recognition
performance. A novel approach to FVR is proposed using Pix2Pix style Generative Adversarial Networks (GANs) for finger vein dataset augmentation providing synthetic images for training VGG16 model. The main objective of the paper is to enhance the quality and diversity of Finger Vein (FV)
datasets while improving the robustness of the recognition system. Our approach involves training a GAN to generate realistic finger vein images that encapsulate the intricate vein patterns present in real-world scenarios. The study evaluates the proposed approach on the THU-FVFDT1 dataset,
considering conventional augmentation and GAN-based augmentation. The results demonstrate that transfer learning from a conventionally augmented dataset to one augmented with GANs yields superior performance, as evidenced by the evaluation metrics. The experimental findings illustrate the
effectiveness of dataset augmentation and transfer learning in the realm of finger vein recognition for biometric identification.
Design and Implement of High Performance Temperature Sensor Based on Computer
Authors: Zhang JianBing , Wei Zhang
Published: November 2024

The sensor system based on computer system has the advantages of low cost and easy expansion. However, real-time clock calibration in computer systems requires high-precision temperature sensors, while heat management applications emphasize ultra-small area and low-voltage operation.
Aiming at the above difficulties and challenges, this paper studies the on-chip CMOS temperature sensor in different signal domains of temperature readout circuit. Firstly, several degenerate points in the front-end circuit of BJT temperature sensor using current gain compensation technology
are analyzed. Secondly, aiming at the problems of advanced design of CMOS temperature sensor and difficult calibration in industrial application, the technology of dynamic component matching, current gain compensation and chopper stabilization is adopted, a novel dynamic current gain cancellation
technique for temperature readout of battery is proposed. Finally, based on this architecture, an all-digital CMOS temperature sensor is realized in SMIC 55 nm CMOS process, and the clock calibration of the computer system is realized.