bluuebunny/crossref_metadata_2025 huggingface dataset:
INTERVENTION PROGRAM WITH THE CLOZE TECHNIQUE: ELABORATION AND CLINICAL SIGNIFICANCE
Authors: Albrecht Renata Graziele Morini , Capellini Simone Aparecida
Published: October 2023

ABSTRACT The hypothesis of this study is based on the fact that a remediation program with the Cloze Technique, leveled by different degrees of difficulties, it can contribute to the development of reading comprehension of students with reading comprehension difficulties. Therefore, the objective was to develop this program and analyze the clinical significance. For this, an intervention program was developed through a bibliographic review and after that a pilot study was carried out and applied in 28 elementary school students, divided into Group I Experimental (students with difficulty in narrative text submitted to the intervention); Group I Control (students with difficulty in narrative text not submitted to the intervention); Group II Experimental (students with difficulty in expository text submitted to the intervention); Group II Control (students with difficulty in expository text not submitted to the intervention). The results analyzed by the JT Method showed a reliable positive change with clinical significance for students in Group I Study, and significantly for students in Group II Experimental.
ACADEMIC PEREZHIVANIE, UNIVERSITY EDUCATION, HUMAN DEVELOPMENT: VYGOTSKY’S CONTRIBUTIONS TO HIGHER EDUCATION
Authors: Garcia Wallisten Passos , Pan Miriam Aparecida Graciano de Souza
Published: October 2023

ABSTRACT This study aims to develop the concept of academic perezhivanie, based on Vygotsky’s concept of perejivânie (perezhivanie), as understood in the works that belong to the final phase of his life (Vygotski, 1934/2018a; Vygotski, 1934/2006a). In understanding perezhivanie as a dynamic unit of consciousness, we find an important conceptual key to understand the psychological university students’ development. We showed that the relation between students and training practices in Higher Education produces academic perezhivanie that mobilize awareness and guide the senses about what it means to be a student and professional in a given area, resulting in transformations that generate new ways of thinking, feelings in university students and positions towards academic life. In this way, the concept of academic perezhivanie constitutes an important tool for the analysis of academic success and failure processes, the quality of training practices and assistance policies and student permanence, as it constitutes a qualitative indicator of university life.
Dance and Music as Integrated Practices in Afro-Brazilian Performances: a technocultural study
Authors: Camargo Andréia Vieira Abdelnur
Published: October 2023

ABSTRACT Dance and Music as Integrated Practices in Afro-Brazilian Performances: a technocultural study – This paper discusses the relationship between dance and music from a technocultural experiment about performative aspects of Bumba Meu Boi of Maranhão. The research mixes research mediated by technology and theoretical discussions on Musicology, Anthropology, Performing Arts as well as testimonials of masters from traditional communities. The study aims to describe and reflect on how Afro-Brazilian cultural performances entangle the phenomena of multimodality, multi-coordination and neighborhood as indispensable factors to conceive an integrated and complex embodied knowledge, indicating inseparability between body, dance and music.
Reflexões sobre o Popular no Contexto do Grupo Mamulengo de Cheiroso de Teatro de Bonecos
Authors: Silva Pedro Rodrigues Pereira da
Published: October 2023

RESUMO Reflexões sobre o Popular no Contexto do Grupo Mamulengo de Cheiroso de Teatro de Bonecos – Este artigo apresenta e discute a noção de cultura e de teatro populares com base na experiência do Grupo Mamulengo de Cheiroso de Teatro de Bonecos (Aracaju/SE), núcleo popular com específica relação com o espaço acadêmico. O estudo é resultado parcial de pesquisa de mestrado e utiliza-se, em maior escala, de revisão bibliográfica, fontes primárias e entrevistas. Por meio das discussões, tem-se uma visão crítica acerca do teatro popular, que pode se manifestar em diferentes lugares, modos e contextos; o que destoa de uma visão estereotipada, largamente homogênea, acerca desses fenômenos, decorrente de uma produção literária que aborda a história sob a ótica da cultura letrada.
Huntington, the disease that transforms everything in its path: Narratives of family caregivers from the Colombian Caribbean coast
Authors: Puello-Alcocer Elsy Cecilia , Jiménez Nydia Nina Valencia , Espitia Auri Cristina Quiceno
Published: October 2023

Abstract Qualitative study to explore the transformations experienced at an emotional, physical, and social level by family caregivers of patients with Huntington’s disease on the Caribbean coast of Colombia. Participants were selected from the Factor H Foundation database, obtaining a theoretical saturation point with 10 life stories telling from the caregiver’s voice, gathered between August 2020 and May 2021. The driving question was refined by a panel of experts and was used with the consent of the participants. The main category, “Huntington, the disease that transforms everything in its path,” was divided into three subcategories: “Transforms my world,” “Transforms my heart and soul,” and “Transforms my body.” These subcategories unveiled that caregivers are mostly women who experienced losses in different aspects of their lives: educational, social, work, affective with strong impacts on their physical and emotional health, and, therefore, in their daily life. It is concluded that Huntington’s disease has adverse signals for the patient, their caregiver and the family; hence the need to focus collective efforts for its comprehensive approach.
Estrategias de acceso a los alimentos implementadas en Venezuela por un grupo de venezolanos que viven en Cuiabá, Brasil
Authors: Vargas John Edinson Velásquez , Gugelmin Silvia Angela
Published: October 2023

Resumen La crisis sociopolítica de Venezuela ha generado diversos problemas como la inseguridad alimentaria, la escasez de productos básicos y medicinas, el aumento del desempleo y la migración masiva hacia otros países de la región. Este estudio tuvo por objetivo identificar las estrategias de acceso a los alimentos vividas en Venezuela por los inmigrantes venezolanos que residen en Cuiabá, en Mato Grosso, Brasil. Esta investigación se realizó bajo el enfoque cualitativo para indagar cómo fue el impacto respecto al acceso y consumo de alimentos en Venezuela vivido por los inmigrantes venezolanos desde la documentación, descripción y comprensión de las experiencias que ellos enfrentan. Se incluyeron 13 participantes, la técnica de recolección de datos que se utilizó fueron las entrevistas individuales. Entre los principales hallazgos encontrados se evidenció que la mayoría de los entrevistados no se sentía a gusto con la alimentación que tenía en Venezuela, dadas las pocas condiciones de acceso y disponibilidad de alimentos, muchos de estos manifestaron percepciones de hambre y angustia por la falta de alimentos, y estas situaciones llevaron a buscar mejores condiciones de vida. La crisis en Venezuela que produjo la poca disponibilidad y acceso a los alimentos les generó estrategias para poder garantizar una alimentación permanente dentro de los hogares donde muchas veces estas estrategias no son acordes a una alimentación saludable y adecuada.
Análise da trajetória dos recursos do Programa Nacional de Alimentação Escolar de 2014 a 2020
Authors: Alencar Nataniele dos Santos , Lima Filipe Augusto Xavier , Araujo Jair Andrade de
Published: October 2023

Resumo O presente estudo busca analisar as alterações nos repasses financeiros do Programa Nacional de Alimentação Escolar (Pnae), e quais os estados, as etapas e as modalidades de Ensino foram as mais prejudicadas no período de 2014 a 2020. Os resultados foram obtidos por meio da estatística e análise descritiva dos dados do Fundo Nacional de Desenvolvimento da Educação (FNDE). As variáveis utilizadas são ano, estados, municípios, etapas, modalidades de Ensino e repasses financeiros. Os resultados mostram que, na maioria dos anos, ocorreu a redução dos repasses financeiros do Pnae, bem como a redução do número de secretarias de Educação estaduais e dos municípios contemplados pelo programa. Destaca-se que em 2020 ocorreu o fechamento das escolas devido à pandemia da Covid-19 e, portanto, houve um número menor de municípios atendidos pelo Pnae.
Mating behavior and sexual dimorphism of the Lobiopa insularis (Coleoptera: Nitidulidae) strawberry pest
Authors: Moliterno Antonioni Campos Acácio , Silva Maycon Roberto da , Zawadneak Maria Aparecida Cassilha , Zarbin Paulo Henrique Gorgatti
Published: October 2023

Abstract The objective of this work was to describe the sexual dimorphism and mating behavior of Lobiopa insularis for the development of pest control and management programs. The morphological characteristics for separating males and females were described with the aid of a stereomicroscope. Mating sequence was recorded over 72 hours with a digital camera. There are differences between males and females in the last abdomen segments, and males maintain a guarding position after mating. The obtained data can be used in monitoring programs to precisely identify the sex of the insects, also shedding light on the ecological features of this pest and Nitidulidae.
A REVIEW OF DUOLINGO STORIES
Authors: Yousefpoori-Naeim Mehrdad
Published: October 2023

Thanks to advancements and innovations in online education, self-study can now beeffectively supported by promoting learner autonomy, self-regulation, and motivation. Inonline language education, Duolingo has been especially successful in engaging learners inself-study through various features. The present study is a brief review of Duolingo Stories,a recent addition to Duolingo, with respect to its potential for maintaining self-study. Adescription of different features of Duolingo Stories is presented along with their implicationsfor self-learning languages. Duolingo Stories provides supplementary reading and listeningpractice with a focus on vocabulary building in a fun, contextualized, and fairly interactiveenvironment. Using a variety of language learning theories and principles, the present studyalso investigates the benefits language learners would gain, as well as the limitations theycould face, when interacting with the stories.
Hypnopompic seizures
Authors: Awad Amer M. , Lüders Hans O.
Published: October 2023

The relationship between epilepsy and sleep is complex and bidirectional. Ictal awakening is probably a common and well‐described phenomenon. In this small observational study we describe arousal from sleep as the only, or at least main, manifestation of some epileptic seizures. We coin the term “hypnopompic seizures” to describe this entity. Five patients with intractable epilepsy were monitored by continuous video‐electroencephalogram. Four of them had left temporal lobe epilepsy and one patient had generalised epilepsy. Hypnopompic seizures accounted for 30‐100% of their seizure types captured during monitoring. All the seizures occurred during stage II sleep and were brief. Hypnopompic seizures are extremely subtle and may be underdiagnosed and underreported. Future larger studies are needed to shed some light on this unique entity and its neuropathophysiology. Epileptologists should be aware of this type of seizure and careful review of electroencephalograms during the transition from sleep to arousal is imperative to capture these seizures. Physicians, patients and families also need to be aware of such a subtle manifestation of seizures. Improved awareness of hypnopompic seizures and subtle seizures, in general, help guide accurate and early diagnosis, thorough monitoring and appropriate management.
Regression of stroke‐like lesions in MELAS‐syndrome after seizure control
Authors: Finsterer Josef , Barton Peter
Published: October 2023

There are some indications that seizure activity promotes the development of stroke‐like episodes, or vice versa, in patients with mitochondrial encephalopathy, lactic acidosis and stroke‐like episodes (MELAS) syndrome or other syndromic mitochondrial disorders. A 41‐year‐old Caucasian female with MELAS syndrome, presenting with short stature, microcytic anaemia, increased blood‐sedimentation rate, myopathy, hyper‐gammaglobulinaemia, an iron‐metabolism defect, migraine‐like headaches, and stroke‐like episodes, developed complex partial and generalised seizures at age 32 years. Valproic acid was ineffective but after switching to lamotrigine and lorazepam, she became seizure‐free for five years and stroke‐like episodes did not recur. Cerebral MRI initially showed enhanced gyral thickening and a non‐enhanced T2‐hyperintensity over the left parieto‐temporo‐occipital white matter and cortex and enhanced caudate heads. After two years without seizures, the non‐enhanced hyperintense parieto‐temporo‐occipital lesion had disappeared, being attributed to consequent seizure control. The caudate heads, however, remained hyperintense throughout the observational period. This case indicates that adequate seizure control in a patient with MELAS syndrome may prevent the recurrence of stroke‐like episodes and may result in the disappearance of strokelike lesions on MRI.
Prevalence of psychiatric comorbidities in temporal lobe epilepsy: the value of structured psychiatric interviews
Authors: Bragatti José Augusto , Torres Carolina Machado , Londero Renata Gomes , Assmann Juliana Bohn , Fontana Vivian , Martin Kelin Cristine , Hidalgo Maria Paz Loayza , Chaves Márcia Lorena Fagundes , Bianchin Marino Muxfeldt
Published: October 2023

Background

Although many studies have demonstrated a high prevalence of psychiatric disorders in epileptic patients, most have used unstructured psychiatric interviews for diagnosis, which may lead to significant differences in results. Here we present a study evaluating the prevalence of major psychiatric comorbidities in a cohort of South Brazilian patients with temporal lobe epilepsy using a structured clinical interview.

Methods

Neuropsychiatric symptoms were analyzed in 98 patients (39 men and 59 women) with temporal lobe epilepsy. Patient mean age was 43 years old, and mean duration of epilepsy was 25 years. Patients were diagnosed according to the ILAE Classification of Epileptic Syndromes using clinical, EEG, and neuroimaging criteria. All patients participated in the Structured Clinical Interview for DSM‐IV (SCID).

Results

Fifty‐three patients (54.1%) presented major psychiatric comorbidities. Mood disorders were observed in 42 patients (42.9%), the most common being neuropsychiatric disorders. Anxiety disorders were the second most frequent disorders, observed in 18 patients (18.4%). Psychotic disorders and substance abuse were each observed in six patients (6.1%). There were no clinical variables regarding epilepsy characteristics (age of onset, duration, response to antiepileptic drugs) and no MRI features associated with psychiatric disorders. A seven‐fold increased risk of mood disorders was identified in patients with inter‐ictal EEG abnormalities associated with the left hemisphere.

Conclusion

Relative to previous reports, we identify a high prevalence of psychiatric disorders in TLE patients, although our data is similar to that observed in other studies which have used similar structured interviews in populations of epileptic patients attending tertiary centres. The wide variation in percentages is probably attributable to the different patient groups investigated and to the even greater variety of diagnostic methods. Structured psychiatric interviews may contribute to a better evaluation of the true prevalence of psychiatric comorbidities in temporal lobe epilepsy.
Greater Wealth, Greater Uncertainty: Changes in Racial Inequality in the Survey of Consumer Finances
Authors: Aladangady Aditya , Chang Andrew C. , Krimmel Jacob
Published: October 2023

We document racial disparities in financial well-being in the 2022 Survey of Consumer Finances. The typical White family had about six times as much wealth as the typical Black family, and five times as much as the typical Hispanic family.
Küresel koordinatlarda ses dalga denklemlerinin Galerkin ağırlıklı artıklar yöntemi ve küresel harmonik fonksiyonlar yardımıyla analizi
Authors: KARASOY Taner , YAĞIMLI Mustafa
Published: October 2023

Ses basınç düzeyinin tespiti, gürültülü ortamlarda çalışan bireyler için önemli bir etmendir. Ses, büyük miktarlarda meydana geldiğinde o ortamda çalışan bireylerin sağlığını ve çalışma güvenliğini tehdit etmektedir. Ses şiddetini ölçmek için periyodik basınç değişikliklerinin belirlenmesi gerektiğinden bu konuda çok sayıda matematiksel analiz ve deneysel araştırma yapılmıştır. Sesin şiddet ölçümlerinde ve sesin mesafelere bağlı dağılım, azalma ve maruziyet analizlerinde klasik logaritmik denklemler kullanılmaktadır. Bu çalışmada sesin periyodik basınç değerlerinin belirlenmesinde daha önce literatürde gözlemlenmemiş olan küresel koordinatlardaki ses dalga denklemlerinin çözümü için Galerkin Ağırlıklı Artıklar Yöntemi (GAAY) ve son yıllarda ses problemlerinden sıklıkla kullanılmaya başlamış olan Küresel Harmonik Fonksiyonlar kullanılmıştır. Yakın alanda ses basıncı seviyelerinin tespitinde yönelme katsayısı ve küresel harmonik fonksiyonlara dayanarak Kritik Mesafe Eşiği r_kri tanımlanmış ve GAAY’dan elde edilen verilerle birleştirilmiştir. Bu sayede elde edilen sayısal ses basıncı değerlerinin klasik logaritmik yaklaşımda kullanılan değerlere oldukça yakın olduğu tespit edilmiş ve bu sayısal veriler için yapılan logaritmik tutarlılık analizi sonucunda klasik logaritmik desibel denklemlerinden elde edilen verilerle yüksek oranda uygunluğu büyük oranda belirlenmiştir. Sonuç olarak hem akustik (ses) bilimine hem de iş sağlığı ve güvenliği bilimine farklı yarı analitik matematiksel çözüm yöntemleri kullanılarak alışılanın dışında matematiksel bir bakış açısı getirilmesi hedeflenmiş ve sayısal verilerle bu bilimsel yaklaşım desteklenmiştir.
mRNA of the OY-TES-1 gene in peripheral blood and tumors in colorectal cancer
Authors: Hilal N. R. , Novikov D. V. , Yakimov V. N. , Pegov R. G. , Novikov V. V.
Published: October 2023

Background. One of the testicular cancer genes is the OY-TES-1 gene, which encodes a proacrosin-binding protein. This gene is known to be expressed in tumor cells.

Aim. To determinate the detection frequency of OY-TES-1 matrix ribonucleic acid (mRNA) in the peripheral blood and tumor of patients with colorectal cancer (CRC) in comparison with the clinical features of the course of a disease in order to assess the potential monitoring significance of this indicator.

Materials and methods. A method for determining the level of OY-TES-1 mRNA based on reverse transcription polymerase chain reaction (RT-PCR). The detection frequency of mRNA OY-TES-1 gene in blood and tumor samples of 66 patients with CRC, as well as the blood of healthy volunteers, was evaluated.

Results. In the peripheral blood of healthy volunteers, no OY-TES-1 mRNA was detected. In the blood of CRC patients, OY-TES-1 mRNA was detected in 13.6 % of cases. In tumors, it was found in 60,6 % of cases. OY-TES-1 mRNA in the blood and in tumor of patients with CRC was detected statistically significantly more often at stages III and IV than at stages I and II (11,0 and 4,5 times, respectively), and also many times more often in tumors with a low degree of differentiation than with highly differentiated tumors. In patients with CRC, the OY-TES-1 mRNA in tumors with metastases in organs and lymph nodes was detected many times more often than in tumors without any metastases (by 16,4 and 17,4 times respectively).

Conclusion. The data obtained indicate the absence of mRNA OY-TES-1gene in the blood of healthy individuals, the appearance of mRNA OY-TES-1 gene in the blood of CRC patients, and the possibility of using the detection of mRNA OY-TES-1 gene in the blood as an additional informative monitoring marker for colorectal cancer.
Detection of a status of microsatellite instability in tumors of patients with endometrioid adenocarcinoma of the ovaries and/or of uterine corpus
Authors: Aniskina A. S. , Payanidi J. G. , Stroganova A. M. , Manina I. V. , Zhordania K. I.
Published: October 2023

Introduction. Multiple primary malignant neoplasms of female reproductive organs are a rare pathology. However, over the past decades, there has been an upsurge of interest in the study of this phenomenon in oncology. This is particularly the case for the diagnosis of synchronous endometrioid adenocarcinoma of the ovaries and uterine corpus, which histogenetically belong to the same germ layer and have similar histological structure. Until recently, clinicians relied only on morphological examination in these cases, but with the development of molecular genetic technologies, new diagnostic possibilities have emerged.

Aim. Is the detection of the status of microsatellite instability in tumors of patients with endometrioid adenocarcinoma of the ovaries and/or uterine corpus.

Materials and Methods. A pilot retrospective molecular genetic study (n = 48) was conducted to determine the status of microsatellite instability (MSI) in the tumors of the ovaries and/or uterine corpus: it involved 33 patients with solitary endometrioid ovarian cancer and 15 patients with synchronous endometrioid adenocarcinoma of the ovaries and uterine corpus. Microsatellite instability status was detected using PCR method with subsequent fragment analysis performed on ABI PRISM 3500 genetic analyzer (8 capillaries, Applied Biosystems). DNA was isolated from paraffin blocks of surgical specimens using DNAsorb B extraction kit (AmpliSens, Russia), according to the manufacturer’s manual. DNA concentration was estimated fluorometrically using Qubit 2.0 (Life Technologies, USA). The obtained data were analyzed using GeneMapper program (Thermo Fisher, USA). In case of polymorphism of two and more markers high-level microsatellite instability (MSI-H) was observed.

Results. The incidence of MSI-H in solitary endometrioid ovarian cancer (n = 33) was 12,1 % (4 cases), while in synchronous ovarian and uterine corpus tumors (n = 15) MSI-H incidence made up 20 % (n = 3). Herewith, there have been only cases of a combination of endometrioid histotypes of ovarian and endometrial cancer with identical status of microsatellite instability. Thus, the incidence of MSI-H in synchronous endometrioid adenocarcinoma of the ovaries and uterine corpus (20 %) is comparable to that in solitary endometrial cancer.

Conclusion. Our pilot study became a significant complement to the previously published materials, as it allowed to confirm the clonal origin of tumors in patients with endometrioid adenocarcinoma of the ovaries and uterine corpus, that can affect the stratification of treatment strategy for this category of patients.
Intestinal anastomoses in children: Experience of pediatric surgeons in the Russian Federation
Authors: Morozov Dmitry A. , Karaseva Olga V. , Sharkov Sergey М. , Morozov Kirill D. , Ayrapetyan Maxim I. , Fedorov Aleksandr К.
Published: October 2023

BACKGROUND: In pediatric surgery, intestinal anastomosis is a standard and responsible operative method used for all age groups. Although advancements in medical technology have significantly changed and expanded the range of surgical interventions, many questions remain, including the safety of intestinal anastomosis in newborns with significant segment discordance, the use of laparoscopic intestinal sutures, the use of mechanical stitching devices, and intestinal anastomosis in peritonitis.
AIM: To determine current problems and future directions in the field of intestinal anastomosis in children in the Russian Federation.
MATERIALS AND METHODS: The study is based on data from 4,558 intestinal anastomosis operations, including 1,735 in newborns, provided by the chief pediatric surgeons of 75 constituent entities of the Russian Federation during 20212022, including the Donetsk and Lugansk Peoples Republics. Based on a questionnaire, the data were summarized and statistically processed.
RESULTS: The study reports on the results of intestinal anastomosis in children in the Russian Federation across various segments of the intestine and age groups. The risks of failure and re-reconstruction significantly increased when duodenal anastomosis was performed laparoscopically and in settings of peritonitis or a compromised intestinal wall (p 0.05). Conversely, the use of laparoscopy and suturing devices in older children for small intestine anastomosis was carried out practically without complications. However, it was performed twice as often in emergencies and against the background of combined problems. In general, the results of small bowel anastomosis under poor conditions were statistically insignificant from intestinal anastomosis with stoma closure (p 0.05). The data revealed that colon surgery, repeated reconstructions, duodenal anastomoses, and small intestine anastomoses in newborns with poor blood flow to the intestinal wall posed the highest risks of anastomotic failure. Small and large intestine surgery in newborns has the highest mortality rate, particularly with peritonitis and circulatory disorders.
CONCLUSIONS: Thus at the current stage of development, intestinal anastomosis in the Russian Federation is characterized by good results, the expansion of indications for anastomosis in conditions of compromised intestine or peritonitis, and the use of laparoscopic techniques and mechanical staplers.
Constraining Wave Velocities for Shallow Depths on Mars
Authors: Mun Eunbi , Kim Byungmin
Published: October 2023

Interior Exploration using Seismic Investigations, Geodesy, and Heat Transport (InSight) landed on Mars on the Elysium Planitia. The InSight had a Seismic Experiment for Internal Structure (SEIS), which contained seismometers that recorded numerous marsquake seismograms. In this study, we propose shear (S)-wave velocity (VS) and compression (P)-wave velocity (VP) profiles at the InSight landing site on Mars by analyzing the initial portions of P-wave seismograms and incidence angles of the six marsquakes. High-quality, low-frequency seismograms are collected. Using the P-wave seismogram method, which is validated for various regions on Earth, we estimate VS values up to a depth of 3400 m. In addition, we compute the incidence angle of the P-wave for the top layer based on the ratio of the initial P-wave amplitude in the radial direction to that in the vertical direction. By hypothesizing the VP profile, we estimate the incidence angles of the P-wave for the other layers, as well as the epicentral distances. Finally, we propose a VP profile up to a depth of 3400 m that minimizes the misfit between the estimated and known epicentral distances. We confirm that the proposed VS and VP profiles agree with those of previous studies.
Fireworks: A Potential Artificial Source for Imaging Near-Surface Structures
Authors: Chu Risheng , Wang Qingdong , Peng Zhigang , Sheng Minhan , Liu Qiaoxia , Chen Haopeng
Published: October 2023

Seismic waves induced by incident acoustic waves from air disturbances can be used to image near-surface structures. In this article, we analyze seismic waveforms recorded by a dense array on the Xishancun landside in Li County, Sichuan Province, southwest China during the Lunar New Year’s Eve (27 January 2017). A total of eight event clusters have been identified as a result of firework explosions. For each cluster, which comprises dozens of individual events with high similarity, we manually pick arrival times of the first event recorded by the array and locate it with a grid-search method. We then rotate three-component waveforms of all events from the east, north, and vertical coordinate system to the local LQT coordinates (L, positive direction perpendicular to the landslide surface and pointing downwards; Q, positive direction is from the launch location of firework to the station along the landslide surface; T, perpendicular to the plane formed by the L and Q directions, and the selected positive direction of the T axis makes LQT form the left-hand coordinate system), and stack the LQT components for those events with cross-correlation values CC ≥ 0.8 with respect to the first event. Characteristics of the stacked LQT components are also examined. The particle motions at each station are retrograde ellipse in the frequency range of ∼5–50 Hz, suggesting air-coupled Rayleigh waves generated by the firework explosions. Spectrograms of the Rayleigh waves also show clear dispersions, which might be used to image near-surface velocity structures. Although we cannot directly extract the phase velocities due to the limitation of the seismic array, our study shows that the fireworks might provide a low-cost and easy-to-use seismic source for imaging near-surface structures.
Development, Characterization and In-vitro Evaluation of Solid Self-Emulsifying Drug Delivery Systems (S-SEDDS) Containing Valsartan
Authors: DİRİL Mine , YILDIZ TÜRKYILMAZ Gülbeyaz , GÜLMEZOĞLU Eda , KARASULU Yesim
Published: October 2023

Hipertansiyon, kardiyovasküler hastalık için ana risk faktörüdür. Valsartan, anjiyotensin II'nin anjiyotensin Tip 1 reseptörü üzerindeki etkisini spesifik olarak bloke ederek yaygın olarak kullanılan, etkili ve iyi tolere edilen antihipertansif ajandır. Ancak gastrointestinal sistemin üst kısmından emilir ve buranın asidik ortamı nedeniyle bu bölgede az çözünür ve oral biyoyararlanımı sadece %25'tir. Bu çalışmanın amacı, Valsartan'ın (VST) ticari formülasyonuna alternatif olarak yeni bir dozaj formu geliştirmektir. Bu amaçla, VST’ın çözünürlüğünü artırmak ve pH'tan bağımsız bir çözünürlüğe sahip olan katı kendiliğinden emülsifiye olabilen ilaç taşıyıcı sistem (S-SEDDS) formülasyonu geliştirmek hedeflenmiştir. VST'ın en yüksek çözünürlük gösterdiği SEDDS bileşenlerini belirlemek için çözünürlük çalışmaları yapılmıştır. Çözünürlük çalışmalarına göre; yağ fazı olarak izopropil miristat (3.5 mg/mL), yüzey etkin maddeler olarak Capyrol 90 (19.8 mg/mL) ve Tween 20 (32.5 mg/mL), yardımcı yüzey etkin madde olarak ise Transcutol HP (168.9 mg/mL) kullanılmıştır. Çözünürlük çalışmaları ile belirlenen yardımcı maddeler ile üçgen faz diyagramları çizilmiştir. VST içeren SEDDS formülasyonları Avicel pH101 ve Hidroksipropil metil selüloz’a (HPMC) ayrı ayrı yaş granülasyon tekniği ile adsorbe edilmiş ve karakterizasyon çalışmaları yapılmıştır. Geliştirilen VST-SEDDS, VST-SEDDS-Avicel ve VST-SEDDS-HPMC formülasyonları pH 1.2 ortamında ticari ürüne göre VST salınımı arttırmıştır. Ayrıca VST-SEDDS-Avicel formülasyonunun açlık, tokluk durumlarından ve pH değişiminden etkilenmediği gözlenmiştir. Bu nedenle VST-SEDDS-Avicel formülasyonunun, pH'tan bağımsız çözünürlüğü arttırdığı ve antihipertansif tedavi için potansiyel bir formülasyon adayı olabileceği söylenebilmektedir.
Determining the factors influencing tourist souvenir expenditure: The case of Turkey
Authors: Kızılcık Onur , Birdir Kemal
Published: October 2023

In this study, information will be explored that will contribute to increasing tourism income in destinations with low tourist expenditure per person. For this purpose, the souvenir expenditure of tourists in Turkey is examined. Souvenir stores in Sultanahmet and the Grand Bazaar in Istanbul were investigated using a qualitative case study research design. Semi-structured interviews were conducted with 11 souvenir sellers and 778 online comments of tourists shopping in souvenir stores were analyzed by netnography. As a result of the research, it has been determined that the efforts made to transform products based on the natural, historical and cultural richness of Turkey into brands, and thus increase local product diversity, play a critical role in increasing souvenir expenditure. On the other hand, the importance of the selection of high spending tourists as the target market and increasing the employment of qualified workers in the tourism sector has emerged.
Scaffold tissue engineering strategies for volumetric muscle loss
Authors: Zhu Christina , Sklyar Karina , Karvar Mehran , Endo Yori , Sinha Indranil
Published: October 2023

Volumetric muscle loss (VML) refers to a composite, en bloc loss of skeletal muscle mass resulting in functional impairment. These injuries normally heal with excessive fibrosis, minimal skeletal muscle regeneration, and poor functional recovery. Functional muscle transfer is a treatment option for some patients but is limited both by the degree of functional restoration as well as donor site morbidity. As such, new therapeutic options are necessary. De novo regeneration of skeletal muscle, by way of tissue engineering, is an emerging strategy to treat VML. This review evaluates available scaffolds for promoting skeletal muscle regeneration and functional recovery following VML. The use of growth factors and stem cell therapies, which may augment scaffold integration and skeletal muscle reconstitution, are also discussed. Regenerative medicine with the use of scaffolds is a promising area in skeletal muscle reconstruction and VML treatment.
Beat-to-beat continuous blood pressure estimation with optimal feature set of PPG and ECG signals using deep recurrent neural networks
Authors: Chen Hanjie , Lyu Liangyi , Zeng Zezhen , Jin Yanwei , Zhang Yuanting
Published: October 2023

Aim: Continuous blood pressure (BP) monitoring can provide invaluable information for cardiovascular disease (CVD) diagnosis. The purpose of this study is to develop a deep recurrent neural network (RNN) model with an optimal feature set of photoplethysmogram (PPG) and electrocardiogram (ECG) signals for continuous BP estimation.

Methods: This paper presents a novel deep recurrent neural network (RNN), which consists of 2-layered bidirectional Long Short-term Memory (Bi-LSTM) and 6-layered LSTM networks. It is used to estimate BP based on the optimal feature set of PPG and ECG signals. In this work, the optimal feature set is determined using five different feature selection methods.

Results: The proposed method is evaluated based on 660 subjects from the University of California Irvine (UCI) machine learning repository. The RNN model with optimal feature set achieved root mean square error (RMSE) of 3.223 and 1.781 mmHg for systolic BP (SBP) and diastolic BP (DBP), respectively. It also showed mean absolute error (MAE) of 2.514 and 1.383 mmHg for SBP and DBP, respectively. Regarding the British Hypertension Society (BHS) standard, the results attained grade A for the estimation of SBP and DBP.

Conclusion: The experimental results suggest that the proposed deep RNN model with an optimal feature set can improve the performance of BP prediction. Thus, it is possible to further apply our proposed method to develop a wearable device for real-time BP monitoring.
The role of PASS and STITCH in the verification of unknown properties of pyruvate and lactate. Literature review and fragments of authors’ own research
Authors: Kolotyeva N. A. , Gilmiyarova F. N. , Gusyakova O. A. , Semashkova E. A.
Published: October 2023

The aim of the study was to identify the predicted spectrum of biological activity of pyruvate and lactate using modern computer modeling methods and to determine potential protein partners in intermolecular interaction.

Materials and methods. The biological activity spectrum of pyruvate and lactate by the structural formula was determined using the PASS (Prediction of Activity Spectra for Substances) software. Potential protein interaction partners for small molecules were predicted using the Search Tool for Interactions Chemicals (STITCH).

Results. Analyzing the obtained results in silico reveals that pyruvate and lactate exhibit diverse biological activities, molecular mechanisms, and pharmacological effects. These include regulation of lipid, protein, and carbohydrate metabolism and effects on enzyme activity and gene expression. The data on the antihypoxic, antiischemic, antitoxic, immunomodulatory, antiinflammatory, antiviral, vasoprotective, and cytoprotective effects are presented. The neuroprotective and antineurotoxic effects of pyruvate and lactate are predicted.

Conclusion. The spectrum of biological activities of lactate and pyruvate were revealed by computer modeling methods, and protein interaction partners were characterized. The small molecules we studied have a coordinating role in the functioning and modulation of mediator, hormonal, receptor, immune, inflammatory, antibacterial, and antiviral responses and gene expression. The use of natural intermediates as therapeutic agents for the treatment of ischemic stroke, acute neurological disorders, and neurodegeneration is discussed, which is underlain by the stimulating effect of metabolites on neuroplasticity. These properties may be manifested through conformational rearrangement of receptors, active binding centers, expression of multiple genes, and changes in the functional manifestations of catalytic and other proteins. The obtained data will obviously expand our understanding of the role of small molecules in intermolecular metabolite – protein interactions.
Diabetic ketoacidosis and cognitive impairment in children and adolescents
Authors: Magomedova K. Sh. , Bykov Yu. V. , Baturin V. A.
Published: October 2023

The aim of the literature review was to highlight modern scientific sources on the formation and clinical manifestations of cognitive impairment in children and adolescents with type 1 diabetes mellitus (DM) after diabetic ketoacidosis (DKA). Type 1 DM is one of the most prevalent endocrine disorders in childhood and adolescence. DKA is the most common acute complication of type 1 DM that may cause cognitive impairment. Cerebral edema is the main cause of cerebral vascular insufficiency in patients with DKA. However, the mechanisms underlying the development of cognitive dysfunction in DKA have not been fully elucidated.

The leading hypotheses include development of neuroinflammation, oxidative stress, disruption of neurogenesis, and neurodegeneration. Hypoxic – ischemic injury and changes in the brain neuroanatomy may also cause cognitive dysfunction. Disruption of some brain structures has been reported after DKA episodes, primarily affecting the white matter. Clinical studies in the pediatric population support the presence of a correlation between the severity and frequency of DKA and the severity of cognitive impairment. Cognitive dysfunction in children and adolescents after a DKA episode can manifest through decreased attention, impaired memory and executive function, and reduced IQ. The earliest possible diagnosis of cognitive impairment in pediatric patients with symptoms of DKA in the context of type 1 DM can improve the treatment prognosis for this endocrinopathy.
A clinical case of myocardial infarction after coronary artery bypass grafting using the internal mammary artery
Authors: Zakharyan E. A. , Shatov D. V. , Grigoriev P. E. , Radkovskaya M. S.
Published: October 2023

Coronary artery bypass grafting (CABG) is the most preferred method of myocardial revascularization in multivessel coronary artery disease and severe progressive forms of the disease. The material of choice for CABG of the left anterior descending artery (LADA) is the internal mammary artery (IMA). However, even when using IMA as a conduit for CABG, one should be aware of a possibility of graft failure, which indicates a need for constant vigilance in this category of patients. Endovascular interventions on coronary arteries make it possible to efficiently and safely revascularize an occluded bypass graft, minimizing existing risks and improving both the quality of life of patients and their subsequent survival. The article considers a clinical case of the development of recurrent anterior myocardial infarction in the patient due to occlusion of the mammary graft to the LADA.
Application of a hydrogel derived from porcine dermis for experimental treatment of superficial wounds
Authors: Melkonyan K. I. , Kozmay Ya. A. , Rusinova T. V. , Chuprynin G. P. , Kartashevskaya M. I. , Kartashevsky I. I. , Storozhuk S. V. , Selezneva I. I. , Gurevich K. G.
Published: October 2023

Aim. To study the efficacy of dermal hydrogel application in the experimental treatment of superficial scarified wounds in rats.

Materials and methods. The hydrogel was obtained from porcine dermis by alkaline hydrolysis. The DNA concentration was determined using the Nano Drop ND-1000 spectrophotometer. The study included 30 male Sphinx rats. Scarified wounds were created on the rat skin, then the rats were divided into two groups: group 1 – rats without treatment, or control group (n = 15), group 2 – rats with wound treatment with the dermal hydrogel for 5 days, or experimental group (n = 15). On day 3, 7, and 14 of the experiment, we explanted skin samples from the wound area and performed routine H&E staining.

Results. On day 3 of the experiment, moderate inflammation, edema, and collagen fiber disorganization were revealed in the experimental group, and pronounced inflammation with purulent exudate was found in the control group. On day 7 of the experiment, inflammation and foci of stratified epithelium were detected in the control group. The histologic analysis of the skin samples from the experimental group showed pronounced plethora of the vessels, necrotic changes of the dermis, and edema. The total thickness of the epidermis and the thickness of its stratum corneum were greater than in the control group samples. On day 14, the differences between the groups were minimal and the epidermis was thickened in the experimental group animals.

Conclusion. The study examined the effects of the dermal hydrogel on scarified wounds in rats. We found faster skin regeneration (by 1.5–2 days) in the experimental group compared to the controls. Besides, the rats of the experimental group were characterized by an increase in the number of fibroblasts in the dermis and thickened epidermis in the affected area.
A direct comparison of the diagnostic efficacy of alternative scaffoldbased radiopharmaceuticals [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3 in patients with HER2-positive breast cancer
Authors: Bragina O. D. , Deyev S. M. , Garbukov E. Yu. , Goldberg V. E. , Chernov V. I. , Tolmachev V. M.
Published: October 2023

Aim. To perform a direct comparison of the diagnostic efficacy of [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE) -G3 in HER2-positive breast cancer patients before the systemic treatment.

Materials and methods. The study included 11 patients with HER2-positive breast cancer (T1–4N0–2M0–1) before the initiation of systemic treatment. All patients underwent a radionuclide examination with [99mTc]TcADAPT6 and [99mTc]Tc-(HE) -G3 with the interval of 3–4 days. Single-photon emission computed tomography (SPECT) /computed tomography (CT) was performed 2 and 4 hours after [99mTc]Tc-ADAPT6 and [99mTc]Tc(HE)3-G3 administration, respectively.

Results. The analysis of [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE) -G3 distribution showed their high uptake in the kidneys and liver. Breast tumors were visualized in all cases. The average tumor uptake of [99mTc]Tc-ADAPT6 was 4.7 ± 2.1, which was significantly higher than in the [99mTc]Tc-(HE)3-G3 injection (3.5 ± 1.7) (p < 0.005, paired t-test). The tumor-to-background ratio (15.2 ± 7.4 and 19.6 ± 12.4, respectively) had no statistical differences in both cases (p > 0.05, paired t-test). Liver metastases were visualized in patients 1 and 5 and corresponded to the projection of metastases according to contrast-enhanced abdominal CT. The accumulation of [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3 in the projection of metastases in both cases was significantly higher compared to the primary tumor (1.3 and 1.7 times higher in patient 1; 2.2 and 3.5 times higher in patient 5, respectively).

Conclusion. Both [99mTc]Tc-ADAPT6 and [99mTc]Tc-(HE)3-G3 demonstrated the diagnostic efficacy in visualizing a primary HER2-positive tumor in breast cancer patients. However, [99mTc]Tc-ADEPT6 had higher accumulation values, which makes it a more promising diagnostic agent.
The level of metabolic hormones in young people with arterial hypertension against the background of abdominal obesity
Authors: Polonskaya Ya. V. , Kashtanova E. V. , Stakhneva E. M. , Shramko V. S. , Sadovski E. V. , Ledovskikh S. R. , Shcherbakova L. V. , Garbuzova E. V. , Khudyakova A. D. , Ragino Yu. I.
Published: October 2023

Aim. To study the level of metabolic hormones in young people with arterial hypertension (AH) against the background of abdominal obesity (AO).

Materials and methods. The study included 498 people who were divided into two groups. The experimental group encompassed 250 people with AH, of which – 159 people had AO, the average systolic pressure – 141.9 ± 13.9 mm Hg, diastolic pressure – 95.6 ± 7.5 mm Hg. The control group included 248 people comparable to the experimental group by gender and age, of whom 104 people had AO, the average systolic pressure – 118.5 ± 9.8 mm Hg, diastolic pressure – 77.8 ± 7.4 mm Hg. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon, insulin, pancreatic polypeptide (PP), and peptide YY (PYY) were determined by the multiplex analysis. The level of glucose was determined by the enzymatic method. Statistical processing of the results was carried out using the SPSS 13.0 software.

Results. Patients with AH had higher levels of amylin, C-peptide, and glucose and lower levels of PYY. There was no significant difference between the experimental group and the control group for the rest of the studied parameters. In the experimental group, the C-peptide, GLP-1, glucagon, and insulin levels were associated with AO. In the control group, the association of AO with the levels of C-peptide, insulin, and glucose was shown. The odds of AH in people under the age of 45 years were associated with a decrease in the level of PYY, a rise in the amylin levels, and an increase in waist circumference.

Conclusion. Of the studied metabolic hormones, an increased level of amylin and reduced PYY can serve as potential biomarkers indicating high odds of developing AH in people under 45 years of age. AO is a factor that contributes to the development of AH at a young age.
All you need to know about sarcopenia: a short guide for an internal medicine physician in questions and answers
Authors: Bikbavova G. R. , Livzan M. A. , Tikhonravova D. V.
Published: October 2023

Sarcopenia is associated with social, economic, and individual burdens, including loss of independence, poor quality of life, and disability. In a short period of time, ideas about sarcopenia transformed from geriatric syndrome to disease. Initially, sarcopenia was considered in the context of gradual age-related deterioration in the functioning of all physiological systems. Over the years, it became clear that it can develop a second time, as a consequence of various diseases and pathological conditions.

To date, there have been no generally accepted diagnostic criteria for sarcopenia. There are several tests and tools available for screening sarcopenia, the choice of which depends on physical capabilities of the patient, capabilities of the medical institution, and the purpose for which it is detected (research or clinical practice).

From the point of view of human health, sarcopenia increases the risk of falls and fractures; impairs the ability to perform daily activities; is associated with the progression of major diseases and cognitive impairments; leads to movement disorders; contributes to a decrease in the quality of life, loss of independence or a need for long-term care. The presence of sarcopenia increases both the risk of hospitalization and hospitalization costs.

The aim of the literature review is to provide an analysis of up-to-date information on the causes, pathogenesis, screening, diagnosis, treatment, and consequences of sarcopenia, myosteatosis, and sarcopenic obesity. The search for literature containing information on relevant studies was conducted in PubMed and Google Scholar by the following keywords: sarcopenia, dynapenia, myosteatosis, sarcopenic obesity, nutritional status, malnutrition.