bluuebunny/crossref_metadata_2025 huggingface dataset:
Data-Driven Framework for Uncovering Hidden Control Strategies in Evolutionary Analysis
Authors: Azzaoui Nourddine , Matsui Tomoko , Murakami Daisuke
Published: October 2023

We devised a data-driven framework for uncovering hidden control strategies used by an evolutionary system described by an evolutionary probability distribution. This innovative framework enables deciphering of the concealed mechanisms that contribute to the progression or mitigation of such situations as the spread of COVID-19. Novel algorithms are used to estimate the optimal control in tandem with the parameters for evolution in general dynamical systems, thereby extending the concept of model predictive control. This marks a significant departure from conventional control methods, which require knowledge of the system to manipulate its evolution and of the controller’s strategy or parameters. We use a generalized additive model, supplemented by extensive statistical testing, to identify a set of predictor covariates closely linked to the control. Using real-world COVID-19 data, we delineate the descriptive behaviors of the COVID-19 epidemics in five prefectures in Japan and nine countries. We compare these nine countries and group them on the basis of shared profiles, providing valuable insights into their pandemic responses. Our findings underscore the potential of our framework as a powerful tool for understanding and managing complex evolutionary processes.
Efficacy and Safety of Apixaban versus Dalteparin as a Treatment for Cancer-Associated Venous Thromboembolism: A Systematic Review and Meta-Analysis
Authors: Arce-Huamani Miguel , Barboza Joshuan , Martínez-Herrera José , Torres-Roman J. , Maguiña Jorge
Published: October 2023

Background and Objectives: Venous thromboembolism (VTE) is common in cancer patients. Anticoagulant therapy with low-molecular-weight heparins (LMWHs) and direct oral anticoagulants (DOACs), such as dalteparin and apixaban, have demonstrated efficacy and safety. However, more comparative research on these drugs is still needed. This study aimed to synthesize evidence on the efficacy of apixaban compared to dalteparin in reducing recurrent VTE, major bleeding, and clinically relevant non-major bleeding associated with cancer. Materials and Methods: We systematically searched the PubMed, Scopus, Web of Science, Embase, Cochrane Library, and ClinicalTrials databases up to 5 January 2023 for randomized controlled trials comparing apixaban versus dalteparin as a treatment for cancer-associated VTE. Five studies were included. Effects according to meta-analyses were reported as relative risks (RRs) and their 95% confidence intervals (CIs). Results: It was found that 33 of 734 (4.5%) patients treated with apixaban and 56 of 767 (7.3%) with dalteparin had recurrent VTE as an efficacy outcome (RR 0.49, 95% CI 0.15–1.58, I2 38%). Major bleeding occurred in 25 of 734 patients treated with apixaban (3.4%) and 27 of 767 patients treated with dalteparin (3.5%) (RR 1.29, 95% CI 0.31–5.27, I2 59%). Likewise, clinically relevant non-major bleeding occurred in 64 of 734 patients treated with apixaban (8.7%) and 46 of 767 (5.9%) patients treated with dalteparin (RR 1.52, 95% CI 1.05–2.19, I2 0%). Conclusions: Apixaban showed a lower risk of recurrent VTE than dalteparin in patients with cancer-associated VTE, albeit with no statistical difference. Statistical significance was observed for no major clinically relevant bleeding but not for major bleeding.
Pregnancy Rates after Hysteroscopic Endometrial Polypectomy versus Endometrial Curettage Polypectomy: A Retrospective Study
Authors: Nishioka Mikiko , Maezawa Tadashi , Takeuchi Hiroki , Hagiwara Katsuyuki , Tarui Sachiyo , Sakamoto Mito , Takayama Erina , Yajima Hideaki , Kondo Eiji , Kawato Hiroaki , Minoura Hiroyuki , Sugaya Ken , Fukuda Aisaku , Ikeda Tomoaki
Published: October 2023

Background and Objectives: A relationship between endometrial polypectomy and in vitro fertilization (IVF) pregnancy outcomes has been reported; however, only a few studies have compared polyp removal techniques and pregnancy rates. We investigated whether different polypectomy techniques with endometrial curettage and hysteroscopic polypectomy for endometrial polyps affect subsequent pregnancy outcomes. Materials and Methods: Data from 434 patients who had undergone polypectomy for suspected endometrial polyps using transvaginal ultrasonography before embryo transfer in IVF at four institutions between January 2017 and December 2020 were retrospectively analyzed. Overall, there were 157 and 277 patients in the hysteroscopic (mean age: 35.0 years) and curettage (mean age: 37.3 years) groups, respectively. Single-blastocyst transfer cases were selected from both groups and age-matched to unify background factors. Results: In the single-blastocyst transfer cases, 148 (mean age: 35.0 years) and 196 (mean age: 35.9 years) were in the hysteroscopic and curettage groups, respectively, with the 148 cases matched by age. In these cases, the pregnancy rates for the first embryo transfer were 68.2% (odds ratio (OR): 2.14) and 51.4% (OR: 1.06) in the hysteroscopic and curettage groups, respectively; the resulting OR was 2.03. The pregnancy rates after up to the second transfer were 80.4% (OR: 4.10) and 68.2% (OR: 2.14) in the hysteroscopic and curettage groups, respectively, in which the OR was 1.91. The live birth rates were 66.2% (OR: 1.956) and 53.4% (OR: 1.15) in the hysteroscopic and curettage groups, respectively, in which the odds ratio was 1.71. These results show the effectiveness of hysteroscopic endometrial polypectomy compared to polypectomy with endometrial curettage. No significant difference was found regarding the miscarriage rates between the two groups. Conclusions: Hysteroscopic endometrial polypectomy resulted in a higher pregnancy rate in subsequent embryo transfer than polypectomy with endometrial curettage. Therefore, establishing a facility where polypectomy can be performed hysteroscopically is crucial.
Does Adding an IPACK Block to the Suprainguinal Fascia Iliaca Block Improve the Quality of Analgesia in Patients Undergoing Knee Arthroplasty under Spinal Anesthesia? A Retrospective Cohort Study
Authors: Kusderci Hatice Selcuk , Genc Caner , Canikli Adiguzel Şenay , Güzel Nizamettin , Tulgar Serkan , Suren Mustafa , Koksal Ersin
Published: October 2023

Background and Objectives: Total knee arthroplasty (TKA) is a commonly performed orthopedic procedure, and is often accompanied by significant postoperative pain. The supra-inguinal fascia iliaca block (SIFIB), similar to an anterior lumbar plexus block, is frequently used in hip surgeries. The interspace between the popliteal artery and capsule of the posterior knee (IPACK) block is a regional anesthesia technique that targets the posterior innervation of the knee capsule. This retrospective study aimed to compare the analgesic effects of SIFIB and SIFIB + IPACK on patients undergoing TKA under spinal anesthesia. Materials and Methods: This retrospective study revealed the data collected from a tertiary hospital. Patient data were gathered for individuals who underwent unilateral TKA under spinal anesthesia during the period between 1 January 2023 and 1 September 2023. Inclusion criteria comprised patients falling within ASA class I–III, those following a standardized perioperative analgesia regimen, and individuals receiving opioids via a patient-controlled analgesia device (PCA) as part of their postoperative pain management strategy. Patients were grouped as SIFIB and SIFIB + IPACK according to the performed regional anesthesia technique. Results: In the study, the data of 88 patients in total, 61 in the SIFIB group and 27 in the IPACK group, were analyzed. The 24 h cumulative morphine consumption was similar in the SIFIB and SIFIB + IPACK groups (10.62 ± 6.58 mg vs. 12.55 ± 8.84 mg, respectively; p: 0.258). The NRS scores of the groups were similar in all time frames. Conclusions: Our study reveals that combining IPACK with SIFIB in the multimodal analgesia plan does not provide additional benefits in terms of postoperative opioid consumption and pain scores in patients undergoing unilateral THA under spinal anesthesia.
A Methodology to Define the Niyama Criterion Reinforced with the Solid Fraction Analysis: Application to Sand Casting of Steel Bars
Authors: Manjabacas María Carmen , Miguel Valentín
Published: October 2023

Niyama and solid fraction criteria are used to predict the solidification porosity and microporosity in computing simulation of casting processes. The solid fraction permits us to determine the areas that solidify last and that are a candidate for presenting porosity if a feeding system is not correctly designed. The Niyama criterion is locally obtained based on the thermal and cooling gradients at a point of the liquid casting. The Niyama value at a casting point varies rapidly from low rates to high ones during the last part of the metal solidification, which demands that the percentage of solidification of the metal is defined to determine the Niyama number. In addition, the Niyama threshold that establishes the soundness of the workpiece can vary according to the nature of the metal or the casting system. In this paper, a methodology to determine the solidification percentage is presented. The method is based on the Niyama number evolution during the solidification process at different key points. These points are validated by the solid fraction criterion as healthy or, on the contrary, as candidates for containing porosity. In addition, some considerations of the solid fraction criterion are visited since the threshold value for which the isolation of the last solidification areas can be defined is not clear. The research is validated by the empirical casting criteria existing in the literature for obtaining sound parts and applied to low-carbon steel bars produced by sand casting.
Effect of the Presence of Structural Defects on the Superconducting Properties of (NbTa)0.67(MoHfW)0.33 and Nb-47wt%Ti
Authors: Nowak Wojciech , Babij Michał , Hanc-Kuczkowska Aneta , Sobota Piotr , Pikul Adam , Idczak Rafał
Published: October 2023

A comparison of the results of studies on the influence of structural defects on the critical parameters of superconductivity has been made for the high-entropy alloy (NbTa)0.67(MoHfW)0.33 and for the conventional superconducting magnet material Nb-47wt%Ti. Positron annihilation lifetime spectroscopy (PALS), electrical resistivity, magnetization and magnetic susceptibility measurements were used. In addition, X-ray powder diffraction studies were performed on the high-entropy alloy (NbTa)0.67(MoHfW)0.33. Due to the rapid cooling of the materials after melting in the arc furnace, they contain a higher concentration of structural defects compared to the heat-treated materials. Magnetic property measurements showed that both the critical temperatures Tc and the upper critical fields μ0Hc2 of bulk superconductivity-related materials are improved in the presence of structural defects.
Paternal Obesity Induced by High-Fat Diet Impairs the Metabolic and Reproductive Health of Progeny in Rats
Authors: Larqué Carlos , Lugo-Martínez Haydée , Mendoza Xiadany , Nochebuena Monserrat , Novo Luis , Vilchis Ricardo , Sánchez-Bringas Guadalupe , Ubaldo Laura , Velasco Myrian , Escalona Rene
Published: October 2023

Due to the increased incidence of obesity, it is of great importance to identify all the possible consequences in those who suffer from it and their descendants. This study aimed to investigate how paternal obesity, resulting from an 18-week high-fat diet (HFD), affects the metabolic and reproductive health of offspring. In the fathers (F0 generation), the HFD led to significant weight gain, primarily due to increased visceral fat. It also resulted in impaired glucose control and reduced insulin sensitivity. Furthermore, F0 males from the HFD group had reduced sperm concentration and lower sperm viability but were still able to sire litters. F1 offspring were monitored during 18 weeks; F1 offspring from obese fathers displayed increased body weight during the experimental window, especially in males, without significant metabolic disturbances. Additionally, F1 males showed reduced sperm viability, indicating potential reproductive implications. On the other hand, F1 females showed normal estrous cycle patterns but had a reduced number of primordial follicles, suggesting a decrease in their follicular reserve and reproductive potential. This study highlights that metabolic and reproductive issues may be passed down to future generations through the paternal line.
Research on Packaging Reliability and Quality Factor Degradation Model for Wafer-Level Vacuum Sealing MEMS Gyroscopes
Authors: Xu Yingyu , Liu Shuibin , He Chunhua , Wu Heng , Cheng Lianglun , Huang Qinwen , Yan Guizhen
Published: October 2023

MEMS gyroscopes are widely applied in consumer electronics, aerospace, missile guidance, and other fields. Reliable packaging is the foundation for ensuring the survivability and performance of the sensor in harsh environments, but gas leakage models of wafer-level MEMS gyroscopes are rarely reported. This paper proposes a gas leakage model for evaluating the packaging reliability of wafer-level MEMS gyroscopes. Based on thermodynamics and hydromechanics, the relationships between the quality factor, gas molecule number, and a quality factor degradation model are derived. The mechanism of the effect of gas leakage on the quality factor is explored at wafer-level packaging. The experimental results show that the reciprocal of the quality factor is exponentially related to gas leakage time, which is in accordance with the theoretical analysis. The coefficients of determination (R2) are all greater than 0.95 by fitting the curves in Matlab R2022b. The stable values of the quality factor for drive mode and sense mode are predicted to be 6609.4 and 1205.1, respectively, and the average degradation characteristic time is 435.84 h. The gas leakage time is at least eight times the average characteristic time, namely 3486.72 h, before a stable condition is achieved in the packaging chamber of the MEMS gyroscopes.
Research on the Mass Adding and Removing Combined Mechanical Trimming Method of the Ring MEMS Gyroscope
Authors: Wang Xinyu , Wu Kai , Wang Chengxiang , Li Qingsong , Hou Zhanqiang , Xiao Dingbang , Wu Xuezhong
Published: October 2023

The MEMS gyroscope is one of the basic units of inertial navigation, whose performance and accuracy is noteworthy. Because of the limitations of processing technology and other factors, the relative manufacturing error of MEMS gyroscopes is usually large. Errors directly lead to a frequency mismatch of resonant structures and consequently restrict the performance improvement of the gyroscope. This study proposes a mechanical trimming technique combining the addition and removal of gold in a ring MEMS gyroscope. Firstly, the analysis of the gyroscope dynamics and error model and trimming theory provides theoretical guidance for the trimming process. Secondly, the method of adjusting the mass is investigated, and the ablation threshold of femtosecond laser parameters on gold is analyzed, which provides the process with parameters for the trimming experiment. Finally, the frequency trimming process is conducted in three steps, including the addition of gold spheres and the removal of gold spheres and gold film, which are applicable to the trimming process at different rates of frequency split. The results shows that the proposed method can reduce the frequency split of the gyroscope from 4.36 to 0.017 Hz.
Design and Implementation of an Online Efficiency-Optimized Multi-Functional Compensator for Wind Turbine Generators
Authors: Ma Chao-Tsung , Zhou Feng-Wei
Published: October 2023

In recent years, the penetration of wind power generation has been growing steadily to adapt to the modern trend of boosting renewable energy (RE)-based power generation. However, the dynamic power flow of wind turbine generators (WTGs) is unpredictable and can have a negative impact on existing power grids. To solve this problem efficiently, this paper presents a multifunctional WTG intelligent compensator (WTGIC) for the advanced power management and compensation of power systems embedded with WTGs. The proposed WTGIC consists of a power semiconductor device (PSD)-based bidirectional three-phase inverter module and an energy storage unit (ESU). In order to reduce system costs and improve reliability, efficiency, and flexibility, various control functions and algorithms are integrated via a modularized all-digital control scheme. In this paper, the configuration of the proposed WTGIC is first introduced, and then the operating modes and related compensation and control functions are addressed. An online efficiency optimization algorithm is proposed, and the required controllers are designed and implemented. The designed functions of the proposed WTGIC include high-efficiency charging/discharging of the ESU, real-time power quality (PQ) compensation, and high-efficiency power smoothing of the WTGs. The feasibility and effectiveness of the proposed WTGIC are verified using case studies with simulations in the Powersim (PSIM) environment and the implementation of a small-scale hardware experimental system with TI’s digital signal processor (DSP) TI28335 as the main controller.
Toward Automatic Monitoring for Anomaly Detection in Open-Pit Phosphate Mines Using Artificial Vision: A Case Study of the Screening Unit
Authors: El Hiouile Laila , Errami Ahmed , Azami Nawfel
Published: October 2023

Phosphorus is a limited resource that is non-replaceable worldwide. Its significant role as a fertilizer underlines the necessity for prudent and strategic management. The adequate monitoring of the phosphate extraction process mitigates anything that can influence the quantity or quality of the product. The phosphate extraction process’s most important phase is the screening unit, which can be used to separate phosphate minerals from unwanted materials. Nevertheless, it encounters several anomalies and malfunctions that influence the performance of the whole chain. This unit requires continuous automated control to avoid any blockages or risks caused by malfunctions. Using artificial intelligence and image processing techniques, the main goal of the investigations described in this paper was to evaluate the performances of machine-learning and deep-learning models to detect the screening unit malfunction in the open pit of the phosphate mine in Benguerir-Morocco. These findings highlight that the CNN and HOG-based models are the most suitable and accurate for the given case study.
Ruthenium-Catalyzed Dehydrogenative Intermolecular O-H/Si-H/C-H Silylation: Synthesis of (E)-Alkenyl Silyl-Ether and Silyl-Ether Heterocycle
Authors: Huang Ziwei , Lin Qiao , Li Jiefang , Xu Shanshan , Lv Shaohuan , Xie Feng , Wang Jun , Li Bin
Published: October 2023

Selective dehydrogenative silylation is one of the most valuable tools for synthesizing organosilicon compounds. In this study, a regio- and stereoselective ruthenium-catalyzed dehydrogenative intermolecular silylation was firstly developed to access (E)-alkenyl silyl-ether derivatives and silyl-ether heterocycles with good functional group tolerance. Furthermore, two pathways for RuH2(CO)(PPh3)3/NBE-catalyzed dehydrogenative intermolecular silylation of alcohols and alkenes as well as intermolecular silylation of naphthol derivatives were investigated with H2SiEt2 as the hydrosilane reagent.
Effect of Wet–Dry Cycling on Properties of Natural-Cellulose-Fiber-Reinforced Geopolymers: A Short Review
Authors: Lv Chun , He Pengyi , Pang Guowei , Liu Jie
Published: October 2023

To study the long-term properties of cement-based and geopolymer materials exposed to outdoor environments, wet–dry cycles are usually used to accelerate their aging. The wet–dry cycling can simulate the effects of environmental factors on the long-term properties of the composites under natural conditions. Nowadays, the long-term properties of geopolymer materials are studied increasingly deeply. Unlike cement-based materials, geopolymers have better long-term properties due to their high early strength, fast hardening rate, and wide range of raw material sources. At the same time, natural cellulose fibers (NCFs) have the characteristics of abundant raw materials, low price, low carbon, and environmental protection. The use of NCFs as reinforcements of geopolymer matrix materials meets the requirements of sustainable development. In this paper, the types and properties of NCFs commonly used for geopolymer reinforcement and the polymerization mechanism of geopolymer matrix materials are summarized. By analyzing the properties of natural-cellulose-fiber-reinforced geopolymers (NCFRGs) under non-wet–dry cycles and NCFRGs under wet–dry cycles, the factors affecting the long-term properties of NCFRGs under wet–dry cycles are identified. Meanwhile, the degradation mechanism and mechanical properties of NCFRG composites after wet–dry cycles are analyzed. In addition, the relationship between the properties of composites and the change of microstructure of fiber degradation is further analyzed according to the results of microscopic analysis. Finally, the effects of wet–dry cycles on the properties of fibers and geopolymers are obtained.
Inhibitory Mechanisms of Lekethromycin in Dog Liver Cytochrome P450 Enzymes Based on UPLC-MS/MS Cocktail Method
Authors: Sun Pan , Cao Yuying , Qiu Jicheng , Kong Jingyuan , Zhang Suxia , Cao Xingyuan
Published: October 2023

Lekethromycin (LKMS) is a synthetic macrolide compound derivative intended for use as a veterinary medicine. Since there have been no in vitro studies evaluating its potential for drug–drug interactions related to cytochrome P450 (CYP450) enzymes, the effect of the inhibitory mechanisms of LKMS on CYP450 enzymes is still unclear. Thus, this study aimed to evaluate the inhibitory effects of LKMS on dog CYP450 enzymes. A cocktail approach using ultra-performance liquid chromatography–tandem mass spectrometry was conducted to investigate the inhibitory effect of LKMS on canine CYP450 enzymes. Typical probe substrates of phenacetin, coumarin, bupropion, tolbutamide, dextromethorphan, chlorzoxazone, and testosterone were used for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2D6, CYP2E1, and CYP3A4, respectively. This study showed that LKMS might not be a time-dependent inhibitor. LKMS inhibited CYP2A6, CYP2B6, and CYP2D6 via mixed inhibition. LKMS exhibited mixed-type inhibition against the activity of CYP2A6 with an inhibition constant (Ki) value of 135.6 μΜ. LKMS inhibited CYP2B6 in a mixed way, with Ki values of 59.44 μM. A phenotyping study based on an inhibition assay indicated that CYP2D6 contributes to the biotransformation of LKMS. A mixed inhibition of CYP2D6 with Ki values of 64.87 μM was also observed. Given that this study was performed in vitro, further in vivo studies should be conducted to identify the interaction between LKMS and canine CYP450 enzymes to provide data support for the clinical application of LKMS and the avoidance of adverse interactions between other drugs.
History of Maturation of Prokaryotic Molybdoenzymes—A Personal View
Authors: Magalon Axel
Published: October 2023

In prokaryotes, the role of Mo/W enzymes in physiology and bioenergetics is widely recognized. It is worth noting that the most diverse family of Mo/W enzymes is exclusive to prokaryotes, with the probable existence of several of them from the earliest forms of life on Earth. The structural organization of these enzymes, which often include additional redox centers, is as diverse as ever, as is their cellular localization. The most notable observation is the involvement of dedicated chaperones assisting with the assembly and acquisition of the metal centers, including Mo/W-bisPGD, one of the largest organic cofactors in nature. This review seeks to provide a new understanding and a unified model of Mo/W enzyme maturation.
Combining Raman Microspectroscopy and X-ray Microcomputed Tomography for the Study of Bone Quality in Apolipoprotein-Deficient Animal Models
Authors: Fertaki Stefani , Giannoutsou Panagiota , Orkoula Malvina G.
Published: October 2023

Raman microspectroscopy and X-ray microcomputed tomography (micro-CT) were used for assessment of the quality of the femur and tibia bones in apolipoprotein-deficient mice compared to control littermates. The cortical and trabecular bone was investigated separately. Raman spectra revealed no differences in the bioapatite-to-collagenous matrix ratio of the cortical bone. The quantities of calcium and collagen, which were measured using atomic absorption spectrometry and thermogravimetric analysis, respectively, were also found to be equal in the two groups. Density and morphometric parameters, which were measured using micro-CT, verified the cortical mineral stability. Bone quality indices were measured using Raman spectra. A decreased collagen crosslink (trivalent-to-divalent) ratio revealed delayed maturation of the collagen network. Such a decrease has been reported in the literature to be connected to decreased bone strength. For the trabecular bone, micro-CT revealed severe osteoporosis in the knock-out group, which was evident from a decreased mineral density, trabecular thickness and increased bone surface/volume ratio. The trabecular bone was not accessible for Raman spectroscopy. According to these results, the cortical and trabecular femur bone is expected to exhibit proneness to fracturing, each for a different reason. A combination of the two techniques was regarded as necessary for an overall assessment of bone quality.
Common Wheat Pasta Enriched with Ultrafine Ground Oat Husk: Physicochemical and Sensory Properties
Authors: Biernacka Beata , Dziki Dariusz , Różyło Renata , Gawlik-Dziki Urszula , Nowak Renata , Pietrzak Wioleta
Published: October 2023

Oat husk (hull) is a byproduct of oat processing that is rich in insoluble fiber. The aim of the study was to evaluate the effect of partially replacing wheat flour with oat husk (at levels of 0, 5, 10, 15, and 20 g/100 g) on the physicochemical properties and sensory acceptance of pasta. Additionally, UPLC-MS/MS analysis was performed to identify phenolic acids and flavonoid compounds, and the cooking properties of the pasta were evaluated. The test results indicate that oat husk significantly (p < 0.05) increased the ash and fiber contents in the pasta, while decreasing the protein and fat contents. Moreover, the redness and yellowness of both raw and cooked pasta increased, while lightness decreased as a result of pasta enrichment with oat husk. Oat husk also led to a decrease in the stretching force of cooked samples, although cooking loss increased significantly but did not exceed 8%. The contents of phenolics and antioxidant activity significantly increased with the incorporation of hull in pasta recipes. UPLC-MS/MS analysis showed that the enriched pasta was especially abundant in ferulic acid. Products with up to 10 g of husk/100 g of wheat flour showed good consumer acceptance. However, higher levels of this additive led to notably lower assessments, particularly in terms of pasta texture.
Phytochemical Content and Antidiabetic Properties of Most Commonly Used Antidiabetic Medicinal Plants of Kenya
Authors: Muema Felix Wambua , Nanjala Consolata , Oulo Millicent Akinyi , Wangchuk Phurpa
Published: October 2023

Traditional medicinal plants have been used for decades in folk medicines in the treatment and management of several ailments and diseases including diabetes, pain, ulcers, cancers, and wounds, among others. This study focused on the phytochemical and antidiabetic activity of the commonly used antidiabetic medicinal species in Kenya. Phytochemical profiling of these species revealed flavonoids and terpenoids as the major chemical classes reported which have been linked with strong biological activities against the aforementioned diseases, among others. However, out of the selected twenty-two species, many of the natural product isolation studies have focused on only a few species, as highlighted in the study. All of the examined crude extracts from thirteen antidiabetic species demonstrated strong antidiabetic activities by inhibiting α-glucosidase and α-amylase among other mechanisms, while nine are yet to be evaluated for their antidiabetic activities. Isolated compounds S-Methylcysteine sulfoxide, quercetin, alliuocide G, 2-(3,4-Dihydroxybenzoyl)-2,4,6-trihydroxy-3 (2H)-benzofuranone, Luteolin-7-O-D-glucopyranoside, quercetin, 1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one and [1,3,11α-Trihydroxy-9-(3,5,7-trihydroxy-4H-1-benzopyran-7-on-2-yl)-5α-(3,4-dihydroxy-phenyl)-5,6,11-hexahydro-5,6,11-trioxanaphthacene-12-one]-4′-O-D-gluco-pyranoside from Allium cepa have been found to exhibit significant antidiabetic activities. With the huge number of adults living with diabetes in Kenya and the available treatment methods being expensive yet not so effective, this study highlights alternative remedies by documenting the commonly used antidiabetic medicinal plants. Further, the study supports the antidiabetic use of these plants with the existing pharmacological profiles and highlights research study gaps. Therefore, it is urgent to conduct natural products isolation work on the selected antidiabetic species commonly used in Kenya and evaluate their antidiabetic activities, both in vitro and in vivo, to validate their antidiabetic use and come up with new antidiabetic drugs.
Progress in Nanostructured Mechano-Bactericidal Polymeric Surfaces for Biomedical Applications
Authors: Kumara S. P. S. N. Buddhika Sampath , Senevirathne S. W. M. Amal Ishantha , Mathew Asha , Bray Laura , Mirkhalaf Mohammad , Yarlagadda Prasad K. D. V.
Published: October 2023

Bacterial infections and antibiotic resistance remain significant contributors to morbidity and mortality worldwide. Despite recent advances in biomedical research, a substantial number of medical devices and implants continue to be plagued by bacterial colonisation, resulting in severe consequences, including fatalities. The development of nanostructured surfaces with mechano-bactericidal properties has emerged as a promising solution to this problem. These surfaces employ a mechanical rupturing mechanism to lyse bacterial cells, effectively halting subsequent biofilm formation on various materials and, ultimately, thwarting bacterial infections. This review delves into the prevailing research progress within the realm of nanostructured mechano-bactericidal polymeric surfaces. It also investigates the diverse fabrication methods for developing nanostructured polymeric surfaces with mechano-bactericidal properties. We then discuss the significant challenges associated with each approach and identify research gaps that warrant exploration in future studies, emphasizing the potential for polymeric implants to leverage their distinct physical, chemical, and mechanical properties over traditional materials like metals.
The Impact of Nutritional Therapy in the Management of Overweight/Obese PCOS Patient Candidates for IVF
Authors: Meneghini Caterina , Bianco Claudia , Galanti Francesco , Tamburelli Valentina , Dal Lago Alessandro , Licata Emanuele , Gallo Mariagrazia , Fabiani Cristina , Corno Roberta , Miriello Donatella , Rago Rocco
Published: October 2023

Polycystic ovary syndrome (PCOS) is the most common female endocrine disorder, and it has two main pathological aspects: reproductive and metabolic. Overweight/obesity is a risk factor in terms of adverse effects during hormone stimulation, a reduced response to ovulation induction regimens, reduced success of IVF, and an increased risk of obstetric complications. To resolve this vicious cycle of pathological events, weight loss and lifestyle modifications are promising strategies. Among these possible approaches, the consumption of a very-low-calorie ketogenic diet (VLCKD) or Mediterranean diet (MD) represents a valid option. In our study, 84 obese/overweight PCOS patients were recruited to evaluate the effects induced by the VLCKD and MD on weight, hormonal, and metabolic parameters. BMI decreased significantly among the VLKCD patients compared to the MD patients (both presenting p values < 0.0001 at 90 and 120 days), and a significant reduction in body circumference was observed. At the same time, HOMA index values statistically decreased for the VLCKD patients compared to those on the MD (p value < 0.001 at 90 days and p value < 0.05 at 120 days), and this phenomenon was also observed for AFC at 90 and 120 days (both p values < 0.001) and AMH at 90 days (p value < 0.05). Interestingly, the ovarian hyperstimulation syndrome (OHSS) incidence was statistically lower in the VLKCD patients compared to the MD patients (p < 0.001). We state that these dietary regimes may improve anthropometric parameters (such as BMI) and women’s reproductive health, restore menstrual regularity, and reduce the risk of OHSS. Regarding the different nutritional therapies, the results suggest that the VLCKD is an optimal choice for entry into IVF, especially in terms of the time range in which these results are achieved.
Food and Nutrient Intake in Children and Adolescents with or without Overweight/Obesity
Authors: Zou Yan , Huang Lichun , Zhao Dong , He Mengjie , Han Dan , Su Danting , Zhang Ronghua
Published: October 2023

Objective: To explore the food and nutrient characteristics of children and adolescents with or without overweight/obesity and to provide scientific basis for the development of prevention strategies on overweight/obesity. Methods: This study included children and adolescents aged 6–17 years who participated in provincial nutrition surveillance which included 90 counties (cities and districts) in Zhejiang Province with a provincial representative. Food consumption was assessed using three consecutive days of 24 h dietary recall, and nutrient intake was calculated using dietary recall in conjunction with the China Food Composition Table. Overweight/obesity was also investigated. Associations were evaluated using ordinal regression models. Results: The analysis included a total of 1827 children and adolescents. The overweight prevalence was 14.0% and the obesity prevalence was 10.1%. Children and adolescents with overweight/obesity were observed to have a higher intake of carbohydrates, iron, sodium, potassium, and magnesium (F = 3.464, 5.232, 5.619, 3.469, 3.934, p < 0.05), as well as having a higher intake of the food group of cereals, tubers and beans, snacks, and salt (F = 7.348, 6.797, 3.413, p < 0.05) compared to children and adolescents without overweight/obesity. After adjusting for potential confounders via ordinal regression models, children and adolescents with overweight/obesity were observed to have a higher intake of carbohydrates (Wald χ2 = 4.325, p < 0.05). There were significant differences concerning the daily energy provided by snacks, the daily carbohydrate intake provided by snacks, the daily sodium intake provided by snacks, and the proportion of snacks to the food group of cereals, tubers, and beans (F = 8.305 6.316, 13.955, 3.692, p < 0.05). Conclusion: Children and adolescents with overweight/obesity have presented a high consumption of carbohydrates, which is associated with the food group of cereals, tubers, and beans. Snacks are the main factor leading to the high intake of the food group of cereals, tubers, and beans among children and adolescents with overweight/obesity.
Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids—The KoALA Study
Authors: Drobner Timo , Braun Theresa S. , Kiehntopf Michael , Schlattmann Peter , Lorkowski Stefan , Dawczynski Christine
Published: October 2023

This study aimed to investigate the impact of influencing factors (sex, eicosapentaenoic acid (EPA) status at baseline, linoleic acid (LA) intake, milk fat intake) on the conversion of α-linolenic acid (ALA) obtained from linseed oil into its long-chain metabolites. In addition, the effect of ALA on cardiovascular risk markers was investigated. This study used a parallel design approach by randomly assigning the 134 subjects to one of four diets (high in LA (HLA); low in LA (LLA); high in milk fat (MF); control (Western diet)) each enriched with linseed oil (10 en%, 22–27 mL ≙ 13–16 g ALA). Blood samples were taken at baseline and after 4, 8, and 12 weeks of dietary intervention. The study was fully completed by 105 subjects (57.4 ± 12.1 years; 65.7% female). Results showed that ALA (296–465%), C-20:4n3 (54–140%), and EPA (37–73%) concentrations in erythrocytes increased in all groups (p < 0.01). In contrast, docosahexaenoic acid (19–35%, p < 0.01) and n-3 index (10–21%, p < 0.05) dropped in the HLA, LLA, and control groups. An increase in C-22:5n3 was only observed in the MF (36%) and control groups (11%) (p < 0.05). In addition, an increase in LA (7–27%) was found in the HLA, LLA, and control groups, whereas C-20:3n6 (16–22%), arachidonic acid (10–16%), C-22:4n6 (12–30%), and C-22:5n6 (32–47%) decreased (p < 0.01). The conversion into EPA was higher in men than in women (69 vs. 39%, p = 0.043) and in subjects with low EPA status compared to participants with high EPA status (79 vs. 29%, p < 0.001). A high LA status attenuates the conversion rate. In line with the literature, no clear effects on blood lipids and parameters of glucose metabolism were found in relation to ALA supplementation.
Retrospective Analysis of a Real-Life Use of Tixagevimab–Cilgavimab plus SARS-CoV-2 Antivirals for Treatment of COVID-19
Authors: Capoluongo Nicolina , Mascolo Annamaria , Bernardi Francesca Futura , Sarno Marina , Mattera Valentina , di Flumeri Giusy , Pustorino Bruno , Spaterella Micaela , Trama Ugo , Capuano Annalisa , Perrella Alessandro
Published: October 2023

Tixagevimab–cilgavimab is effective for the treatment of early COVID-19 in outpatients with risk factors for progression to severe illness, as well as for primary prevention and post-exposure prophylaxis. We aimed to retrospectively evaluate the hospital stay (expressed in days), prognosis, and negativity rate for COVID-19 in patients after treatment with tixagevimab–cilgavimab. We enrolled 42 patients who were nasal swab-positive for SARS-CoV-2 (antigenic and molecular)—both vaccinated and not vaccinated for COVID-19—hospitalized at the first division of the Cotugno Hospital in Naples who had received a single intramuscular dose of tixagevimab–cilgavimab (300 mg/300 mg). All patient candidates for tixagevimab–cilgavimab had immunocompromised immune systems either due to chronic degenerative disorders (Group A: 27 patients) or oncohematological diseases (Group B: 15 patients). Patients enrolled in group A came under our observation after 10 days of clinical symptoms and 5 days after testing positivite for COVID-19, unlike the other patients enrolled in the study. The mean stay in hospital for the patients in Group A was 21 ± 5 days vs. 25 ± 5 days in Group B. Twenty patients tested negative after a median hospitalization stay of 16 days (IQR: 18–15.25); of them, five (25%) patients belonged to group B. Therefore, patients with active hematological malignancy had a lower negativization rate when treated 10 days after the onset of clinical symptoms and five days after their first COVID-19 positive nasal swab.
A Diamond Terahertz Large Aperture Photoconductive Antenna Biased by a Longitudinal Field
Authors: Kononenko Vitali V. , Bukin Vladimir V. , Komlenok Maxim S. , Zavedeev Evgeny V. , Kononenko Taras V. , Dezhkina Margarita A. , Ratnikov Pavel P. , Dolmatov Timophey V. , Chizhov Pavel A. , Ushakov Alexander A. , Konov Vitaly I. , Garnov Sergey V.
Published: October 2023

The novel design of a terahertz large aperture photoconductive antenna (LAPCA) is reported. It features a longitudinal orientation of the bias electric field within the photoconductive substrate, and has the advantage of a small interelectrode gap, resulting in a higher field for the same applied voltage. The proposed LAPCA configuration has been tested with a nitrogen-doped (∼10 ppm) synthetic monocrystalline diamond, which is a promising material for high-intensity and high-power terahertz sources. Two antennas with different high-voltage electrode realizations were assembled, pumped by a 400 nm femtosecond laser, and tested for THz emitter function. The experimental data are found to be in good correlation with the numerical simulation results. The performance of antennas with the conventional transverse E-field configuration and the novel longitudinal configuration is compared and discussed.
The Content of Anthocyanins in Cowpea (Vigna unguiculata (L.) Walp.) Seeds and Contribution of the MYB Gene Cluster to Their Coloration Pattern
Authors: Krylova Ekaterina А. , Mikhailova Aleksandra S. , Zinchenko Yulia N. , Perchuk Irina N. , Razgonova Mayya P. , Khlestkina Elena K. , Burlyaeva Marina O.
Published: October 2023

The intensively pigmented legumes belonging to Phaseolus and Vigna spp. are valued as an essential component of healthy nutrition due to their high content of flavonoids. In this context, we used the accessions of Vigna unguiculata with different colors of seed coats from the N.I. Vavilov All-Russian Institute of Plant Genetic Resources collection as the main object of this research. We applied confocal laser scanning microscopy, biochemical analysis, and wide in silico and molecular genetic analyses to study the main candidate genes for anthocyanin pigmentation within the MYB cluster on chromosome 5. We performed statistical data processing. The anthocyanin content ranged from 2.96 mg/100 g DW in reddish-brown-seeded cowpea accessions to 175.16 mg/100 g DW in black-seeded ones. Laser microscopy showed that the autofluorescence in cowpea seeds was mainly caused by phenolic compounds. The maximum fluorescence was observed in the seed coat, while its dark color, due to the highest level of red fluorescence, pointed to the presence of anthocyanins and anthocyanidins. Genes of the MYB cluster on chromosome 5 demonstrated a high homology and were segregated into a separate clade. However, amplification products were not obtained for all genes because of the truncation of some genes. Statistical analysis showed a clear correlation between the high content of anthocyanins in cowpea seeds and the presence of PCR products with primers Vigun05g0393-300-1.
Mechanical Anisotropy of Injection-Molded PP/PS Polymer Blends and Correlation with Morphology
Authors: Takayama Tetsuo , Shibazaki Rin
Published: October 2023

The molecular orientation formed by melt-forming processes depends strongly on the flow direction. Quantifying this anisotropy, which is more pronounced in polymer blends, is important for assessing the mechanical properties of thermoplastic molded products. For injection-molded polymer blends, this study used short-beam shear testing to evaluate the mechanical anisotropy as a stress concentration factor, and clarified the correlation between the evaluation results and the phase structure. Furthermore, because only shear yielding occurs with short-beam shear testing, the yielding conditions related to uniaxial tensile loading were identified by comparing the results with those of three-point bending tests. For continuous-phase PP, the phase structure formed a sea-island structure. The yield condition under uniaxial tensile loading was interface debonding. For continuous-phase PS, the phase structure was dispersed and elongated in the flow direction. The addition of styrene–ethylene–butadiene–styrene (SEBS) altered this structure. The yielding condition under uniaxial tensile loading was shear yielding. The aspect ratio of the dispersed phase was found to correlate with the stress concentration factor. When the PP forming the sea-island structure was of continuous phase, the log-complex law was sufficient to explain the shear yield initiation stress without consideration of the interfacial interaction stress.
Influence of Isothermal Aging on Microstructure and Shear Property of Novel Epoxy Composite SAC305 Solder Joints
Authors: Zhang Peng , Xue Songbai , Liu Lu , Wang Jianhao , Tatsumi Hiroaki , Nishikawa Hiroshi
Published: October 2023

With the rapid iteration of microsystem integrated technology, the miniaturization of electronic devices requires packaging materials with higher reliability. In this work, the microstructure evolution and mechanical properties of novel epoxy composite SAC305 solder joints were studied after isothermal aging to evaluate the enhanced effect of epoxy addition. The thickness variation and morphological evolution of the interfacial layer were analyzed. The results showed that, as the aging time was prolonged, the Cu6Sn5 interfacial layer remarkably coarsened and Cu3Sn compounds formed between the Cu6Sn5 layer and Cu pad due to the continuous atomic diffusion. Compared with the monolithic joint, the epoxy composite SAC305 joints had a lower overall IMC growth rate during aging, closely related to the initial morphologies of the interfacial layers. The shear test results showed an apparent decrease in the shear forces of all the solder joints as the aging time increased. Nevertheless, because of the extra mechanical support provided by the epoxy layer, the epoxy composite joints demonstrated notably enhanced mechanical properties. After 1000 h aging treatment, the shear force of SAC305 joints containing 8 wt.% epoxy was 26.28 N, showing a 24.08% increase over the monolithic joint. Cu-Sn IMCs were detected on the shear fracture of the monolithic joint after 1000 h aging, indicating the fracture occurred near the interface and displayed a ductile/brittle mixed fracture. Concerning the epoxy composite joints, cracks were still initiated and extended within the solder bulk, demonstrating a noticeable enhancement in ductility due to the addition of epoxy.
Stable Surface Modification by Cold Atmospheric-Pressure Plasma: Comparative Study on Cellulose-Based and Synthetic Polymers
Authors: Chiper Alina Silvia , Borcia Gabriela
Published: October 2023

This study’s aim is a comparison of the plasma-induced effects on polymers exposed in helium and argon gaseous environments in a pulsed dielectric barrier discharge at atmospheric pressure. Cellulose-based and synthetic polymers are tested with regard to a range of parameters, such as wettability, adhesion, surface energy and polarity, the oxygen amount in their structure, and surface morphology. The surface properties are analyzed by contact angle measurements, X-ray photoelectron spectroscopy, and scanning electron microscopy images. The results point to the efficient and remarkably stable modifications of the plasma-exposed surfaces, such as their enhanced adhesion, surface energy, and oxygen incorporation. Additionally, plasma provides significant oxygen uptake in cellulose-based materials that bear already prior to treatment a high amount of oxygen in their structure. The comparison between the properties of the non-permeable, homogeneous, smooth-surface synthetic polymer and those of the loosely packed, porous, heterogeneous cellulose-based polymers points to the different rates of plasma-induced modification, whereby a progressive alteration of cellulosic surface properties over much larger ranges of exposure durations is noted. Present experimental conditions ensure mild treatments on such sensitive material, such as paper, and this is without alterations of the surface morphology and the physical degradation of the material over a large range of treatment duration.