bluuebunny/crossref_metadata_2025 huggingface dataset:
In Silico Prediction of Binding Affinities of Hybrid Molecules of Benzothiazole cross-linked with Hydroxamic acid by certain linkers
Authors: Alqaysi Yazen , Shakir M. Alwan  , Ashour H. Dawood
Published: February 2024

New hybrid molecules of Benzothiazole cross-linked with hydroxamic acid through an amino acid or aminoalkanoic acid are suggested. All the synthesized hybrid molecules (2A-E) were subjected to molecular docking to evaluate their binding affinities with histone deacetylase enzyme (HDAC8, PDB ID: 1T69) and recorded lower ΔG (-8.117, -6.322, -8.16, -7.939, - 9.46, respectively)
than Vorinostat (suberoylanilide hydroxamic acid, SAHA), as the reference ligand, which recorded a much less value of -5.375, using the Maestro software (Schrödinger, version 2022-1).  Moreover, compound 2E, which is Benzothiazole-p-amino benzoic acid-hydroxamate has recorded the lowest binding score (-9.460). This may indicate that this compound is the most active hybrid molecule. There were no violations from Lipinski’s rule and all the synthesized hybrid molecules comply with all parameters.  SwissADME server was employed for the in silico molecular docking for prediction of the physicochemical and ADME properties of the investigated compounds.  All hybrid molecules showed low possible passive oral absorption and no penetration into BBB. The hybrid molecules 2B and 2D may be considered as P-gp substrates. SAHA does not inhibit any of the CYP enzymes used in this study, while, the hybrid molecules 2B, 2D and 2E have shown possible inhibitory activities.
Synthesis, Molecular Docking, Characterization, and Preliminary Evaluation of Some New 1, 3-Diazetidin-2-One Derivatives as Anticancer Agents
Authors: Haidar Farah , Faisal Mahdi Monther , Kareem Khan Ayad
Published: February 2024

A series of novel 1,3-diazetidin-2-one derivatives were designed, synthesized, and evaluated preliminary (In Vitro) for their cytotoxic activity against the lung (A549) cancer cell line. GOLD software (version 2021.2.0) was used to conduct a molecular docking study;
the tested derivatives demonstrated significant anticancer activity compared to the reference drug (erlotinib). PLP-fitness values for the final compounds are 79.81, 80.80, and 81.57, respectively, whereas the reference ligand, erlotinib, had a value of 76.20. The synthesized compounds were identified and characterized using physicochemical parameters (melting points and Rf values), FTIR, 1H-NMR, and 13C-NMR spectroscopy. According to the IC50 values for the synthesized derivatives, compounds N4a and N4b exhibit outstanding anti-proliferative activity with IC50 value of (7.51, 7.68) µM against A549 cell line, compared to erlotinib, which has an IC50 value of (11.5) µM.
Exploring Memory Inhibition Techniques in Tan Twan Eng's The Garden of Evening Mists and Kazuo Ishiguro's The Remains of the Day
Authors: Alharbi Sarah , Alamri Dawla
Published: February 2024

This paper offers a psychoanalytical reading of the human memory’s dilemma as portrayed by Tan Twan Eng in The Garden of Evening Mists (2011) and Kazuo Ishiguro in The Remains of the Day (1989). Its objective is to analyze the role of memory in shaping the fragmented self, particularly in the context of the trauma from the world wars, employing a psychoanalytical perspective demonstrated through Michael Anderson’s memory inhibition techniques and Carl Jung’s theories on active imagination, which prioritize the unconscious mind. The study applies two methods of selective memory to the protagonists’ behaviors: retrieval-induced forgetting in Ishiguro’s The Remains of the Day and the think/no-think paradigms in Eng’s The Garden of Evening Mists. These approaches aim to explore the role of intention in these inhibition processes and investigate whether these experiences yield positive or negative outcomes. Through a close analysis of the main characters’ repressed memories, the study argues that the protagonists employ selective memory techniques differently. In The Garden of Evening Mists, intentional and positive utilization of these techniques helps overcome the horrors of war. Conversely, in The Remains of the Day, unintentional and negative application enhances the illusion of falsely representing oneself. This study’s primary contribution lies in exploring the mechanisms underlying the control of postcolonial/imperial traumatic memories. Additionally, it delves into the significance of the natural world in the protagonists’ healing and recovery revealing that gardens serve as a metaphor for recovery due to their profound impacts.
PREPARATION AND CHARACTERISATION OF ZnO THIN FILMS DEPOSITED BY RF SPUTTERING METHOD
Authors: Abdullahi Bilyaminu , Abdullahi S. , Abdullahi M. B. , Wara A. M.
Published: February 2024

Zinc oxide (ZnO) thin films deposited on corning glass substrates at 100ºC substrate temperature by radio frequency deposition were annealed the open air and icrowave oven at 150ºC. The influence of open-air annealing (OAA) and microwave annealing (MWA) were studied. The results obtained showed that MWA annealing can improve not only the crystal but also the optical properties of the ZnO thin films. A high transmittance is obtained in all the annealed samples (S1, S2, S4 and S5) demonstrating >90% at 650 nm wavelength. Reflectance in all the samples was < 29% with a minimum standing at 23.78% as recorded for sample S5. The band gap for the annealed samples (S1, S2, S4 and S5) was determined at 3.26 eV, 3.32 eV, 3.29 eV and 3.34 eV respectively. Absorption coefficient stood at 0.0225 cm-1, 0.0179 cm-1, 0.0180 cm-1, 0.0186 cm-1 and 0.0181 cm-1 for the as-deposited sample and the respectively. The optical and structural properties analysis showed that OAA and MWA annealing at suitable temperatures considered can significantly improve some properties of the ZnO thin films making the films suitable for applications in optoelectronics and photovoltaics.
Eredeti és áthelyezett fészkekből kikelt közönséges levesteknős (chelonia mydas) fiókák páncélalakjának összehasonlítása
Authors: Adilov Alexandra Kamilla , Kiss Csaba
Published: February 2024

Az elmúlt néhány évtizedben összességében csökkent az összes tengeriteknős-populáció, ami közvetlenül és közvetve tulajdonítható az élőhelyek pusztulásának, ideértve a fészkelő partszakaszok fejlesztését emberi lakhatásra. Bizonyítékok vannak arra is, hogy a fiatal egyedek erőteljes ragadozása, a tojások és a kifejlett egyedek orvvadászata, a szennyezés és a nem megfelelő halászati gyakorlatok is jelentősen hozzájárultak a megfigyelt populáció csökkenéséhez. A közönséges levesteknős faj megőrzésére irányuló erőfeszítések közé tartozik a veszélyeztetett fészkek áthelyezése. Azonban mivel a módszer nem veszélytelen, mivel az áthelyezés hatással van a fiókák embrionális fejlődésére és azok kikelést követő fenotipusos meg jelenésére, számos kutatás foglalkozik a témával. Kutatásomban az egyik ilyen hatással, a 2D pikkelymorfológia változásával foglalkoztam Észak-Cipruson. Főkomponens-analízist végeztem, ahol azt határoztam meg, mely környezeti háttérváltozók vannak a legnagyobb hatással a fészekre, illetve azon jellegeket vizsgáltam, amelyek a legnagyobb hányadát magyarázzák a teljes fenotípusos varianciának. A páncél alak- és méretváltozásainál a Prokusztész ANOVA-teszt statisztikailag szignifikáns eredményt mutatott a csoportok között az alakra. A nem parametrikus ANOVA-teszt a csoportok közötti különbségeket mutatta. Eredményeink rámutatnak az áthelyezett fészkek és az eredeti fészkek közti különbségekre és az azokra ható környezeti tényezőkre, melyek ismerete fontos lehet a faj túlélése szempontjából.
Nyári terepgyakorlat Montenegróban
Authors: Földi Kristóf , Nagy Levente , Várnagy Dorka , Murányi András , Murányi Dávid
Published: February 2024

2023 júniusában önköltséges terepgyakorlatot szerveztünk a balkáni fauna és flóra tanulmányozására. Montenegró három hegységében (Sinjajevica, Rumija, Visitor), a tengerszinttől 1900 méterig felhatolva végeztünk terepi gyűjtéseket és megfigyeléseket, továbbfejlesztve a Biológiai Intézet hazai terepgyakorlatain elsajátított fajismeretet és gyűjtéstechnikai tudást. A gyűjtésekhez a University of Montenegro adott engedélyt, az út során régi kooperációs partnerünkkel, Vladimir Pešić professzorral is együtt töltöttünk némi időt. A gyűjtött anyag az Állattani Tanszék hallgatói bemutató, illetve kutató gyűjteményébe került.
Uzgoj maslina u unutrašnjosti Dalmacije
Authors: Strikić Frane
Published: February 2024

Unutrašnjost Dalmacije je područje između planinskih masiva Velebita, Dinare i Kamešnice sa sjevera te brdsko planinskih lanaca Kozjak, Mosor i Biokovo na jugu koji stvaraju prirodnu prepreku između ovog prostora i obalnog dijela Dalmacije. Cijelo područje Unutrašnjosti Dalmacije na osnovi pedoloških i klimatskih karakteristika može se podijeliti u šest zasebnih cjelina. Poljoprivredna proizvodnja je tradicionalna djelatnost stanovništva ovog područja, a glavne poljoprivredne grane su stočarstvo, vinogradarstvo i ratarstvo. Iako se u ovom području mogu pronaći veoma stara stabla masline, maslina nije tradicionalna kultura niti ona predstavlja značajniji gospodarski potencijal. Analizom klimatskih prilika, a prvenstveno temperatura zraka koje su ograničavajući čimbenik uzgoja masline, može se zaključiti kako je najhladnije područje Sinja, a najtoplije područje Ravnih kotara. Učestalost pojave niskih temperatura u području Sinja tijekom zimskog mirovanja i ranog proljeća od 41 % u travnju do 83 % u veljači ukazuje na činjenicu nemogućnosti uzgoja masline. Unatoč ovoj činjenici u cijelom području unutrašnjosti Dalmacije postoje mikrolokacije na kojima je moguć uzgoj masline uz određena manja ograničenja. Najčešće su to područja nekadašnjih vinograda. Svakako, prije donošenja odluke o sadnji masline potrebno je detaljno analizirati klimatske prilike svake pojedine mikrolokacije.
Prilog poznavanju rodnih izbojaka trešnje
Authors: Čmelik Zlatko , Boljak Čmelik Ranka
Published: February 2024

Rodno drvo trešnje čine dugi i kratki izbojci. Dugi izbojci su mješoviti jer u bazalnom dijelu lateralno nose generativne, a u gornjem dijelu vegetativne pupove. U kategoriji kratko rodno drvo razlikujemo: a) kratke mješovite izboje (u bazalnom dijelu su generativni, a u vršnom vegetativni pupovi), b) svibanjske kitice (kratki rodni izboji bez vidljivih nodija) koje imaju vršni vegetativni pup, a lateralno nose 3-5 (ili više) generativnih pupova, i c) buketne kitice (vršni pup je vegetativan, a bočni su generativni, ali imaju izražene nodije. Struktura rodnih izboja, uz ostale čimbenike, određuje rodni habitus.
ANALISIS BIAYA LOGISTIK MILITER DARI PERANG TELUK (1990-1991)
Authors: Nurbaiti Nurbaiti , Sasongko Nugroho Adi
Published: February 2024

Penelitian ini didesain untuk mendapatkan pemahaman tentang pembiayaan sektor logistik di Perang Teluk (1990-1991). Penelitian ini menggunakan teori logistik. Sumber data yang digunakan adalah data sekunder yang diperoleh dari US Department of Defense, US Office of Management and Budget, US Congressional Budget Office, US Government Accountability Office. Analisis data yang digunakan adalah analisis data model Miles dan Huberman yaitu reduksi data, display data dan verifikasi dengan menggunakan pendekatan hermeneutik. Validitas data menggunakan: (1) kredibilitas; (2) keteralihan (transferability); (3) kebergantungan penelitian terhadap data yang didapatkan; dan (4) kepastian. Hasil penelitian adalah pada operasi Desert Shield dalam sektor logistik dan energi diperkirakan menghabiskan $1,603 miliar sedangkan Desert Storm dibutuhkan biaya $28,658 miliar. Setelah dianalisa lebih lanjut, didapatkan bahwa dalam Desert Shield dan Desert Storm menghabiskan energi (bahan bakar) sebesar $3,932 miliar dan logistik berupa senjata dan fasilitas pendukung $ 3,319 miliar, makanan tentara sebesar $2,110 miliar, mesiu sebesar $621 juta dan jika ditotalkan biayanya sekitar $9,982 miliar. Biaya ini terbantu karena mendapatkan bantuan dari Negara koalisi khususnya Arab Saudi.
KEPEMIMPINAN PRESIDEN MEGAWATI PADA ERA KRISIS MULTIDIMENSI, 2001-2004
Authors: Soekarnoputri Megawati
Published: February 2024

Pada 1997 - 1998, Indonesia menghadapi berbagai macam krisis yang menimbulkan gejolak dan mengubah jalannya sejarah bangsa ini. Dimulai dari krisis ekonomi nasional, dan berlanjut pada munculnya berbagai bentuk ancaman, seperti konflik etnis dan agama, serta maraknya separatisme dan terorisme. Krisis multidimensi tersebut berpotensi menghantar Indonesia pada perpecahan dan dicap sebagai negara gagal. Penelitian ini bertujuan untuk memberi pemahaman tentang hubungan antara krisis multidimensi dan kepemimpinan presiden pada kurun waktu tahun 2001 hingga 2004. Untuk mencapai tujuan tersebut, penelitian kualitatif dengan pendekatan studi kasus dipakai untuk menggali tacit knowledge dari pengambil keputusan tertinggi saat itu, yang tidak lain adalah Presiden Republik Indonesia kelima Megawati Soekarnoputri. Penelitian ini menggunakan kerangka teori Byman dan Pollack (2001) sebagai pisau analisis dengan metode penelitian kualitatif. Hasil temuan penelitian yang diperoleh antara lain, walaupun dalam masa pemerintahan yang relatif singkat, kepemimpinan Presiden Megawati Soekarnoputri, berhasil mengatasi sebagian besar krisis multidimensi yang dihadapi oleh Indonesia saat itu. Kebijakan strategis di bidang ekonomi, politik, hukum, sosial, dan lingkungan diambil Â dengan landasan pemikiran yang inovatif, melalui berbagai upaya dialog, perundingan, pembuatan program, pengesahan peraturan perundang-undangan, hingga pemberlakuan operasi militer demi menjaga kedaulatan dan keamanan Negara Indonesia. Dampak dari berbagai kebijakan tersebut masih bisa dirasakan hingga saat ini, seperti pemilihan umum secara langsung, otonomi daerah, meletakan fondasi pembangunan kemaritiman. Keberhasilan tersebut menjadi landasan yang kokoh bagi presiden selanjutnya untuk melanjutkan program pembangunan dan peningkatan kesejahteraan rakyat di Indonesia. Salah satu kontribusi penelitian ini adalah mengeksplisitkan aspek-aspek yang melatarbelakangi pengambilan keputusan strategis pada era 2001-2004, yang diharapkan bisa berguna bagi perkembangan ilmu pengetahuan dan saran praktis dalam rangka proses penyusunan perencanaan dan kebijakan strategis pembangunan, baik pada tataran suatu negara maupun global.
STRATEGY TO PREVENT DETERIORATION OF PANCASILA VALUES IN THE INDONESIAN TOURIST GUIDE ASSOCIATION MEMBER
Authors: Putra Galih Adi , Wirajuda Muhammad Hadianto , Risman Helda
Published: February 2024

The focus of warfare has transformed from traditional armed forces to asymmetric warfare, resulting in the rise of extremism across various layers of society. This research explores the decline of Pancasila values among Indonesian Tourist Guide Association members. This study aims to formulate appropriate strategies that uphold Pancasila values within the framework of the tourism industry. The study employs a rigorous library research methodology, reviewing various academic literature, including books, training material, and prior research. Additionally, observational analyses of the tourist guide training process are conducted to determine its correlation with contemporary violence involving tourist guides. The research recommends that relevant institutions adapt the existing training curriculum by integrating additional instructional material on Pancasila values and their practical application within the nuanced context of the tourism industry. Addressing this issue, the study, particularly within the Indonesian Tourist Guide Association, contributes significantly to the scholarly discourse on countering extremism and violence.
BATALYON KAVALERI ROK 2011 DALAM MENDUKUNG TUGAS PENGAMANAN IBUKOTA JAKARTA
Authors: Nurheldi Fikri , Midhio I Wayan , Prasetyo Triyoga Budi
Published: February 2024

Batalyon Kavaleri 9/SDK merupakan satuan jajaran Kodam Jaya/Jayakarta untuk mendukung tugas pengamanan Ibukota. Dihadapkan dengan perkembangan Alutsista, Batalyon Kavaleri TNI AD menggunakan 2 (dua) jenis Organisasi dan Tugas (Orgas) yakni Orgas ROK 2011 dan Orgas ROK 2013. Batalyon Kavaleri 9/SDK melaksanakan penyesuaian Orgas menjadi Orgas ROK 2011 mulai tahun 2016 sehingga menyebabkan perubahan terhadap personel, materil dari satuan. Namun disisi lain, Batalyon Kavaleri 9/SDK melaksanakan penugasan dalam mendukung tugas pengamanan Ibukota dengan karakteristik berbeda dengan Batalyon Kavaleri yang berada di Kotama lain. Dalam melaksanakan tugas pengamanan Ibukota, Batalyon Kavaleri 9/SDK melaksanakan tugas siaga pengamanan Ibukota, Objek Vital Tentara Nasional Indonesia (TNI), Alat Utama Senjata TNI, Bantuan kepada Kepolisian Republik Indonesia, dan Pengamanan Very Very Important Person (VVIP). Tujuan Penelitian untuk mengetahui Implementasi Orgas ROK 2011 dalam mendukung tugas pengamanan Ibukota, kendala dalam penerapan Orgas tersebut serta upaya yang dilakukan. Penelitian dilaksanakan dengan pendekatan kualitatif dengan menggunakan teknik wawancara, observasi dan studi dokumentasi. Berdasarkan hasil penelitian didapatkan bahwa penerapan Orgas ROK 2011 di Batalyon Kavaleri 9/SDK belum efektif dihadapkan pada pelaksanaan tugas pengamanan Ibukota. Hal tersebut karena dalam penerapan Orgas ROK 2011 terdapat kendala pada bidang personel dan materiil untuk dapat mendukung tugas pengamanan Ibukota tersebut. Oleh karena itu, diperlukan validasi Orgas Satuan Kavaleri secara khusus dalam melaksanakan tugas pengamanan Ibukota
PERAN TNI AU DALAM MENINGKATKAN KEMAMPUAN CTDLS (COMMUNICATION TACTICAL DATA LINK SYSTEM) GUNA MENDUKUNG PENGAMANAN WILAYAH PERBATASAN
Authors: Fajar Randy , Silitonga Tatar Bonar , Kustiawan Bambang
Published: February 2024

Wilayah perbatasan di Indonesia memiliki kerentanan yang besar, sehingga menjaga keamanan wilayah udara sangat penting. Dalam meningkatkan kemampuan bidang keamanan, TNI AU mengambil beberapa langkah, termasuk peningkatan operasional kekuatan dengan sistem komunikasi yang efektif dan efisien. Communication Tactical Data Link System (CTDLS) merupakan sistem yang memungkinkan pertukaran data dari suatu unit udara dan darat melalui jaringan data link. Peralatan ini merupakan embrio Network Centric Warfare (NCW) TNI AU dan terdiri dari Airbone Unit, Base Station Unit dan Command Control Unit. Dalam penelitian berjudul "Peran TNI AU Dalam Meningkatkan Kemampuan CTDLS (Communication Tactical Data Link System) Guna Mendukung Pelaksanaan Kegiatan Operasi Pengamanan Wilayah Perbatasan", penelitian ini berfokus pada evaluasi kemampuan operator dan teknisi CTDLS, serta kesiapan infrastruktur yang mendukungnya dan juga regulasi dan perangkat lunak (software). Dengan pendekatan kualitatif dan metode analisis data Miles dan Huberman, penelitian ini menggali informasi melalui wawancara mendalam, observasi partisipatif, dan analisis dokumen. Hasil penelitian menunjukkan gambaran kualitas dan kuantitas operator dan teknisi CTDLS, serta kesiapan infrastruktur dan kondisi perangkat lunak yang digunakan. Kesiapan dan kemampuan personel operator dan teknisi CTDLS TNI AU saat ini belum optimal. Hal ini disebabkan oleh keterbatasan pelatihan, mutasi personel, dan kekurangan jumlah personel di beberapa satuan, terutama di Puskodalau. Selain itu, infrastruktur pendukung CTDLS, seperti ruang Command Control (C2) dan alokasi peralatan, belum memadai, khususnya di Puskodalau dan Puskodal Koopsud I, II, dan III. Keterbatasan ini menghambat operasi pengamanan di wilayah perbatasan. Ditambah lagi, kekurangan regulasi yang spesifik dan kebutuhan untuk pengembangan serta pembaruan perangkat lunak menjadi penghalang dalam pengoperasian dan pemeliharaan sistem. Diperlukan peningkatan infrastruktur, penyusunan regulasi yang sah, serta pengembangan software untuk mendukung kegiatan operasi pengamanan wilayah perbatasan. Kesimpulan dari penelitian ini menegaskan pentingnya pemahaman mendalam mengenai kesiapan operasi pengamanan perbatasan dengan kemampuan CTDLS untuk meningkatkan efektivitas dan keberhasilan operasi tersebut
Inteligencia de negocios para la gestión del talento humano: mejorando la eficiencia organizacional
Authors: Sánchez Lunavictoria Jacqueline Carolina , Gaibor Coello Andy Sebastian , Leon Muñoz Leonela Elizabeth , Tenemaza Fernández Daniela Alejandra
Published: February 2024

Introducción: Este artículo científico examina la relación entre la inteligencia de negocios y la gestión de talento humano y cómo influye en la eficiencia y competitividad de las organizaciones. El objetivo que se plantea en esta investigación es analizar la relación entre la inteligencia de negocios con la gestión del talento humano. Se utilizó una metodología teórica que incluyó una investigación transversal con un enfoque deductivo. La información teórica previamente publicada en fuentes confiables y relevantes fue interpretada y analizada en este estudio. Los resultados ponen de relieve la importancia de la inteligencia de negocios como fuente crucial de datos para la gestión del talento humano. La inteligencia de negocios y la gestión del talento humano van de la mano para mejorar la eficacia organizativa y permitir la planificación estratégica, la supervisión y la administración. En conclusión, este artículo demuestra que la combinación de inteligencia de negocios y la gestión del talento humano permite a las organizaciones tomar decisiones informadas por las necesidades de los empleados y su desarrollo profesional. Esto mejora la gestión del talento al identificar las habilidades y los puntos fuertes de cada empleado dentro de la organización. Área de estudio general: Administración. Área de estudio específica: gestión del talento humano.
Pelatihan Pembuatan Bahan Ajar Digital Berbasis Flipbooks bagi Guru di Kota Pekanbaru Riau
Authors: Yulis Putri Ade Rahma , Dafit Febrina , Fitriani Fitriani , Amnestya Prilla
Published: February 2024

This community service activity aims to enhance the knowledge and skills of teachers in creating digital teaching materials based on flipbooks to realize a multimedia-based Islamic school. The implementation method of this community service involved training and mentoring 34 teachers at Arsyad Islamic School in Pekanbaru. The instruments used include questionnaires on the percentage of technology usage in teaching and questionnaires on the teachers' abilities related to using digital teaching material creation applications, which were then analyzed descriptively. The results of this community service showed that there was an improvement in teachers' understanding of the role of technology in teaching and their ability to produce digital learning resources such as flipbooks. Before the training, 48.4% did not master the skills, 31.3% had a sufficient level of mastery, 18.8% were proficient, and 0% were highly proficient in creating digital teaching materials. After the training, there was an improvement, with 0% having no mastery, 34.4% having a sufficient level of mastery, 50% being proficient, and 12.5% being highly proficient. It indicates that the community service activity has impacted teachers' understanding and skills.
Allergy to Egg Yolk - Case Report and Literature Review
Authors:   Immunology and Allergy, Department of Pediatrics, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical city-WR, Jeddah 9515, Saudi Arabia, AL-Zahrani Daifulah
Published: February 2024

Egg is one of the most commonly eaten foods worldwide and egg allergy is the second most common food allergy. We report an adult patient who was previously healthy and tolerating eggs through out, then developed allergic reactions to egg yolk confirmed by positive skin prick test with commercially available extracts for egg yolk and negative for egg white.
Non-native barnacle accelerates the recovery from disturbance of intertidal mussel beds
Authors: Soria SA , Gutiérrez JL , Palomo MG
Published: February 2024

The barnacle Balanus glandula is a non-native species inhabiting Argentinian rocky shores. The native mussel Brachidontes rodriguezii forms extensive beds in the mid-intertidal zone of these shores, generating a physical structure that determines the diversity of the assemblage. Yet, this native foundation species is prone to mortality due to disturbances associated with extreme climatic events. The aim of this study was to experimentally investigate the role of early-colonizing, non-native B. glandula in the succession process and the recovery of mussel beds following disturbance. Experimental plots were demarcated in the mussel bed and initially cleared of mussels, to produce exposed rock surfaces similar to those that form after a disturbance event. Half of these plots were kept barnacle-free throughout the experiment by removing all recruiting B. glandula, whereas all recruits were allowed to develop in the remaining plots. Our results showed that mussel cover at the end of the experiment was higher in the plots with barnacles. The plots with and without barnacles followed different successional trajectories, with increasing limpet densities and reduced cover of crustose algae in the presence of barnacles during early successional stages. The results indicate that the presence of B. glandula at the early stages of succession can alter successional dynamics and facilitate the recovery of mussel bed cover after disturbance events. More broadly, this study also shows that non-native species, although frequently considered a ‘nuisance’, can accelerate the recovery of foundation species that characterize entire communities and sustain the greatest share of their diversity.
Lactation curve modelling in dairy production
Authors:   , Chen Yongyan
Published: February 2024

Various metrics have been proposed to evaluate milk production of dairy cows, like cumulative milk production over a specific period (e.g., 305 days, 365 days, or an entire lactation) and milk yield per day within a certain period. These metrics are based on simple calculations on raw data. However, they provide an overview of milk production performance without capturing changes in milk production over the entire lactation period. These changes, or patterns in milk production offer more information (e.g., peak yield, peak time, persistency) about the lactation, which can be useful for breeding and selection, health monitoring, and other applications. Lactation curve models can extrapolate and quantify lactation curves and estimate actual production from incomplete data sets, generating various lactation curve characteristics (LCC) to describe the curve in different ways. LCC can serve as a metric to evaluate milk production performance at the cow level and have diverse applications in various dairy research fields. However, some important research topics have received insufficient attention.
This thesis was conducted to explore the application of lactation curve modelling based on farm data collected on commercial dairy farms in the Netherlands and Belgium. Applications in cow reproduction performance and herd economic performance were developed. Four objectives were formulated: (1) to predict lactation persistency for DIM 305 at different insemination moments, (2) to investigate the association between days post conception and persistency, (3) to summarize cow lactation curves into herd lactation curve characteristics (HLCC) and illustrate a field application of HLCC, and (4) to compare whether HLCC or the herd’s average 305-day milk production (HM305) is better able to explain herd economic performance.
Experimental and Numerical Perspectives on The Role of Localization and Heating in Small-Magnitude Earthquakes
Authors:   , Hung Chien-Cheng
Published: February 2024

Small-magnitude earthquakes (M < 4) have received escalating attention in recent years owing to the global surge in human-induced seismicity. Subsurface activities such as hydrocarbon production can lead to triggering of faults cutting the reservoir system, sometimes bringing significant societal unrest. To evaluate the risk of induced events, it is important to understand the strength and behavior of the fault during fast movement (i.e. slip velocity > 1 m/s). This requires a full characterization of the process of where slip occurs and how faults strength breaks down due to frictional heating from rupture nucleation to propagation. This thesis focuses on Europe's largest gas field, the Groningen gas field in the Netherlands, as a case study for small-magnitude earthquakes under upper crustal conditions.

Against this background, I performed laboratory experiments on sandstone-derived fault gouge materials, coupled with numerical modeling to simulate Groningen earthquakes under (near) in-situ conditions. A key finding is the pivotal role of pore fluid in weakening a gouge-filled fault during seismic slip, attributed to thermal expansion of pore fluid. This weakening process operates at various scales, from millimeter-scale shear-bands to micrometer-scale grain-to-grain contacts, leading to distinct stages of weakening. Pore fluid properties and host-rock materials influence the efficiency of heating and weakening, with microstructural analyses revealing the impact of initial gouge microstructure and slip localization development. The results provide better constraints on slip-weakening parameters enhancing geomechanical models of seismicity in the Groningen reservoir system but can also provide input for feasibility studies of future projects in the subsurface.
SYNERGISTIC APPROACHES TO STRATEGIC MANAGEMENT: MODELS AND IMPACT ON THE PERFORMANCE OF ORGANIZATIONS
Authors: DOMYSHCHE-MEDYANYK ALLA , ZELICH VIKTORIA , NOVIKOVA MARYNA , BIELSKA TETIANA , RAIKO DIANA
Published: February 2024

In the current dynamic business environment, the ability of organizations to manage and innovate effectively is becoming a crucial factor for success and competitiveness. In this context, synergistic management approaches are of particular relevance since they offer the integration of different functions and processes to achieve better results than are possible by using traditional methods. The relevance of the topic is determined by the need for a more comprehensive understanding of the mechanisms of synergy in management and its impact on organizations’ efficiency. The purpose of this research is to analyze synergistic models of strategic management with a focus on their key features, advantages and limitations. Modern organizational structures and strategic procedures are the object of the research. In our research, we applied a comprehensive methodological approach that combines a systematic approach, analysis and synthesis, and comparison. This gave us the opportunity to conduct an in-depth analysis of the interactions between different components in the organizational system, opening up new perspectives in understanding synergies in management. The application of these methods also made it possible to effectively assess how synergistic strategies influence the overall management efficiency, providing valuable insights into optimizing organizational processes.
THE ROLE OF INTERNATIONAL TRANSPORT LOGISTICS IN OPTIMIZING TRANSPORT INFRASTRUCTURE ARCHITECTURES
Authors: BOBRAKOV ANATOLII , XIAOYU HUANG , FEI WU , KULIK MYKHAILO , IVANENKO DMYTRO , GAVRYLOVSKYI OLEKSANDR
Published: February 2024

Nowadays, transport infrastructure is a crucial component of any social and economic system. The arrangement of infrastructure is a top priority in economic activity due to the globalization of international logistics. This study aims to comprehensively analyse the transport infrastructure system regarding architectural objects. It also seeks to identify the main issues of the management paradigm in the industry and options for solving them. The research employed general scientific methods of cognition, including logical and structural analysis, comparison, theoretical modelling, abstraction, induction, and deduction, as well as statistical methods, specification, generalization, and formalization. The article examines innovative approaches to developing transport infrastructure in the international logistics system. The authors analysed the main issues, challenges, and achievements of managing the architectural component of transport infrastructure. The paper concludes that the effective use of transport infrastructure capabilities is essential for increasing the productivity of economic processes. The authors also identified the position and role of architectural objects in the international logistics system.
FOREIGN LANGUAGE COMMUNICATIVE COMPETENCE OF FUTURE AND CURRENT SPECIALISTS IN THE LEGAL SPHERE, PUBLIC ADMINISTRATION AND LAW ENFORCEMENT AGENCIES AS A COMPONENT OF GENERAL PROFESSIONAL COMPETENCE
Authors: BALANAIEVA OKSANA , MAMONOVA OLENA , DYKHTA NATALIA , ARDELIAN OLENA
Published: February 2024

In the context of globalization, the foreign language communicative competence of lawyers and police officers becomes especially important. Such competence allows for a better understanding of the persons when they do not speak the native language of the lawyer or the police officer. The study aims to identify cases where foreign language communicative competence has a special significance for lawyers and police officers. The research employs analysis, synthesis, generalization, and formal-structural methods. The paper examines a set of norms regulating the use of foreign language communicative competence by lawyers and police officers in civil, criminal, administrative, and economic legal proceedings. The study analyzes the necessity of proficiency in a second, non-native language based on various legislative acts, including the Constitution of Ukraine, the Law of Ukraine "On Security Activities," the Law of Ukraine "On the Judiciary and the Status of Judges," the Law of Ukraine "On the National Police," the Law of Ukraine "On the Bar and Legal Practice," and the Law of Ukraine "On Notariate." A positive aspect of criminal procedural legislation is noted regarding the requirement to ensure the competence of a translator when involved in criminal proceedings.
POLITICAL LEADERSHIP IN THE REPRESENTATIVE POWER OF UKRAINE IN THE CONTEXT OF GLOBAL CHALLENGES
Authors: GOSHOVSKA VALENTYNA , DANYLENKO LYDIIA , DUDKO IRYNA , GOSHOVSKYI VOLODYMYR , REITEROVYCH IHOR
Published: February 2024

Political leadership in the modern world is becoming increasingly relevant against the backdrop of new challenges that require a quick and effective response on the part of politicians as representatives of particular political institutions. As a matter of tradition, parliaments are collegial bodies, in contrast to the institution of the president, which possesses sole decision-making power. However, representative bodies of power have the right to adopt laws that define the principles of life in the country and society. Parliamentary leaders play a crucial role in drafting and adopting bills, which requires studying this phenomenon. The purpose of the academic paper is to analyze parliamentary leadership as a significant element of representative democracy. The research methodology is based on a combination of three key approaches that allow analyzing political leadership – the theory of traits, behavioral and situational theories. The main research methods are as follows: analysis of documents, secondary analysis of sociological data, the case study method, and general scientific methods (analysis and synthesis, deduction, generalization, and classification). Representative democracy has been undergoing a process of transformation due to the challenges of postmodernity.
TRAINING TEACHERS TO WORK IN THE CONDITIONS OF DIGITAL TRANSFORMATION OF EDUCATION
Authors: ANDRIICHUK TAMARA , SHOSTAK IRYNA , INDRIKA RENĀTE , BOTUZOVA YULIIA , DONII NATALIIA
Published: February 2024

In the modern educational paradigm, determined by the rapid development of digital transformation, training teachers to work in new conditions has reached a strategically important stage. The academic paper analyzes the process of preparing teachers for the effective use of digital technologies in the educational environment. Particular attention is paid to the key stages of training and assessment of the results of the experiment. The authors present empirical data in the form of tables that reveal the level of teachers’ competence of the experimental and control groups at different stages of training. Analysis of these data shows that the program was successful in training of teachers for the new challenges of the digital age. The academic paper is intended for researchers and practitioners in the field of education seeking to understand and optimize the process of teachers’ training. The research results provide a basis for developing more effective curricula and strategies aimed at successfully adapting teachers to the dynamics of digital transformation in modern education. The academic paper highlights not only the technical aspects of teaching digital technologies to teachers but also the importance of the pedagogical approach and adaptation of teachers to the new requirements of the educational environment. The training programs were evaluated using statistical methods, such as the calculation of chi-square values, which allow determining the statistical significance of differences between the experimental and control groups.
THE USE OF GIS FOR ECOLOGICAL AND LANDSCAPE LAND MANAGEMENT OF HUMAN SETTLEMENTS
Authors: SHEVCHUK SERHII , GAPON SVITLANA , CHUVPYLO VADYM , NAHORNA SVITLANA , KURYSHKO ROMAN
Published: February 2024

The issue of forming an analytical and informational base for management decisions in the field of land affairs is particularly relevant given the global trend of systemic social transformations. It requires active implementation of the latest information technologies. The study aims to comprehensively analyze the aspects of using geographic information systems (GIS) for ecological and landscape land management of human settlements. The research was carried out using general scientific methods of cognition: logical and structural analysis, induction and deduction, comparison, abstraction, specification, generalization, and formalization. The article investigates the basics of GIS and variations of their implementation in the field of land management. It highlights the main provisions and algorithmic structure of the process. The authors described the typical features of modern GIS technologies and their capabilities in the spheres of mapping, monitoring, and other aspects of land management. The main problems, challenges, and achievements of the GIS utilization process are considered. It has been determined that the effective utilization of GIS capabilities is a promising priority area for optimizing the land utilization system. The practical significance of the findings of this paper is manifested in the feasibility of using them in developing suitable programs to improve the efficiency of ecological and landscape land management of settlements. Also, the study's results can be used to form a universal effective model of GIS technologies application during the process of land utilization management.
‘Oh, so that’s what it was like!’: The Personal Essay in Hard Times
Authors: Spinner Jenny
Published: February 2024

This article explores characteristics of personal essays, primarily written by American essayists, that appeared in 2020 during the COVID-19 pandemic and protests against racial injustice that erupted around the U.S. It does so against the historical backdrop of essays that were written during other global hard times, particularly the second wave of the bubonic plague epidemic in the 1500s, when Montaigne wrote The Essays, and the 1918 flu pandemic. It notes significant differences in the contemporary responses – for one, an extraordinary level of detail about life in a pandemic – many of which unite around a communal despair over pandemic losses, outrage at racism, and hope for a better future. One of the challenges faced by essayists in public hard times is how to position their personal experiences amid a public calamity. Writers of colour, the author contends, face additional challenges as they navigate the complexities and pressures of representational narratives.
Data-to-Deal (D2D): An Emerging and Effective Approach to Financing the Climate Transition
Authors: Luscombe Hannah , Richardson Emma , Foster Vivien , Howells Mark , Quirós-Tortós Jairo , Jaramillo Gil Marcela , Money Alex , Taliotis Constantinos , Quejada Marietta , Chiang Pamela , Orozco Dileimy , Alfstad Thomas , Bock Franziska , Dominguez Cristina , Partasides Georgios , Pye Steve , Mulugetta Yacob , Rogner Holger , Kinyanjui Boniface , Gullberg Monica , Cem Gundogan Arif , Isik Mine , Hawkes Adam , Millot Ariane , Woods Jeremy , van Dam Koen , Sridharan Vignesh , Tan Naomi , Zagato Ligia , Ryan-Collins Lily , Blyth Will , Achaichia Sarah , Fuchs Janina , Somavilla Lucas , Tesfamichael Meron , Sewe Raymond , Osei-Owusu Simone , Lubello Pietro , Zilliacus Johanna , Dali Slim , Abrahams Leslie , Montgomery Mikenna , Almada Rolando , Pearson Lucy , Cannone Carla , Dalkmann Holger , Yeganyan Rudolf , Edeme Darlain , Grafakos Stylianos , Vrochidis Ioannis , van der Lugt Iris , Pereira Ramos Eunice , Saavedra Gomez Valentina , Lee Sangji , Gankhuyag Uyanga , Pappis Ioannis , Lindblad Nicolina , Liza Michael , Zepeda Miramontes Eduardo , Emtairah Tareq , Mukuri Felister , Mutembei Martin , Tembo Bernard , Sharpe Simon , Shivakumar Abhishek , Walsh Gareth , Gentle Christopher , Ali Izhaar , Gritsevskyi Andrii , Guragain Dipesh , De León Denegri Felipe , Ahmed Imad , Mofor Linus , Stringer Martin , Mwabonje Onesmus , Sukpanit Paisan , Sherina Alvarez Paola , Zhang Riqi
Published: February 2024

Developing nations encounter significant challenges in accessing the necessary finance to meet climate goals. The emerging ‘Data-to-Deal’ approach is a collaborative effort by 60 specialists, which aims to address this by providing a flexible framework of options, tailored to individual country circumstances, aiming to enhance core functions and capabilities; it serves as a basis for concrete action, informing capacity building, technical assistance, and research. This paper argues for the mainstreaming of a holistic approach to accessing climate finance by outlining the components of the Data-to- Deal pipeline and showing the effectiveness of Data-to-Deal through the demonstration of its successful implementation in Costa Rica.
Enhanced solute transport and steady mechanical stimulation in a novel dynamic perifusion bioreactor increase the efficiency of the in vitro culture of ovarian cortical tissue strips
Authors: Fragomeni Gionata , De Napoli Luigi , De Gregorio Vincenza , Genovese Vincenzo , Barbato Vincenza , Serratore Giuseppe , Morrone Giuseppe , Travaglione Angela , Candela Andrea , Gualtieri Roberto , Talevi Riccardo , Catapano Gerardo
Published: February 2024

Introduction: We report the development and preliminary evaluation of a novel dynamic bioreactor to culture ovarian cortical tissue strips that leverages tissue response to enhanced oxygen transport and adequate mechanical stimulation. In vitro multistep ovarian tissue static culture followed by mature oocyte generation, fertilization, and embryo transfer promises to use the reserve of dormant follicles. Unfortunately, static in vitro culture of ovarian tissue does not promote development of primordial to secondary follicles or sustain follicle viability and thereby limits the number of obtainable mature oocytes. Enhancing oxygen transport to and exerting mechanical stimulation on ovarian tissue in a dynamic bioreactor may more closely mimic the physiological microenvironment and thus promote follicle activation, development, and viability.

Materials and Methods: The most transport-effective dynamic bioreactor design was modified using 3D models of medium and oxygen transport to maximize strip perifusion and apply tissue fluid dynamic shear stresses and direct compressive strains to elicit tissue response. Prototypes of the final bioreactor design were manufactured with materials of varying cytocompatibility and assessed by testing the effect of leachables on sperm motility. Effectiveness of the bioreactor culture was characterized against static controls by culturing fresh bovine ovarian tissue strips for 7 days at 4.8 × 10−5 m/s medium filtration flux in air at −15% maximal total compressive strain and by assessing follicle development, health, and viability.

Results and Conclusions: Culture in dynamic bioreactors promoted effective oxygen transport to tissues and stimulated tissues with strains and fluid dynamic shear stresses that, although non-uniform, significantly influenced tissue metabolism. Tissue strip culture in bioreactors made of cytocompatible polypropylene preserved follicle viability and promoted follicle development better than static culture, less so in bioreactors made of cytotoxic ABS-like resin.
Rotation-traction manipulation induced intradiskal pressure changes in cervical spine—an in vitro study
Authors: Han Changxiao , Feng Minshan , Wen Haibao , Yin Xunlu , Li Jing , Du Wuyin , Peng Bochen , Liu Guangwei , Zhu Liguo
Published: February 2024

Objective: Evaluate the effect of rotation-traction manipulation on intradiskal pressure in human cervical spine specimen with different force and duration parameters, and compare the intradiskal pressure changes between rotation-traction manipulation and traction.

Methods: Seven human cervical spine specimens were included in this study. The intradiskal pressure was measured by miniature pressure sensor implanting in the nucleus pulposus. rotation-traction manipulation and cervical spine traction were simulated using the MTS biomechanical machine. Varied thrust forces (50N, 150N, and 250N) and durations (0.05 s, 0.1 s, and 0.15 s) were applied during rotation-traction manipulation with Intradiscal pressure recorded in the neutral position, rotation-anteflexion position, preloading, and thrusting phases. Futuremore, we documented changes in intradiscal pressure during cervical spine traction with different loading forces (50N, 150N, and 250N). And a comparative analysis was performed to discern the impact on intradiscal pressure between manipulation and traction.

Results: Manipulation application induced a significant reduction in intradiscal pressure during preloading and thrusting phases for each cervical intervertebral disc (p < 0.05). When adjusting thrust parameters, a discernible decrease in intradiscal pressure was observed with increasing thrust force, and the variations between different thrust forces were statistically significant (p < 0.05). Conversely, changes in duration did not yield a significant impact on intradiscal pressure (p > 0.05). Additionally, after traction with varying loading forces (50N, 150N, 250N), a noteworthy decrease in intradiscal pressure was observed (p < 0.05). And a comparative analysis revealed that rotation-traction manipulation more markedly reduced intradiscal pressure compared to traction alone (p < 0.05).

Conclusion: Both rotation-traction manipulation and cervical spine traction can reduce intradiscal pressure, exhibiting a positive correlation with force. Notably, manipulation elicits more pronounced and immediate decompression effect, contributing a potential biomechanical rationale for its therapeutic efficacy.
Slow-sculpting graphene oxide/alginate gel loaded with platelet-rich plasma to promote wound healing in rats
Authors: Chen Ningjie , Li Mengjie , Yang Jincun , Wang Peng , Song Guodong , Wang Haitao
Published: February 2024

Wounds, especially chronic wounds, have become an important problem that endangers human health. At present, there are many repair methods, and among them combines materials science and biology is one of the important repair methods. This study explored the preparation method, physicochemical properties, biological activity and safety of Platelet-Rich plasma (PRP)-loaded slow-sculpting graphene oxide (GO)/alginate gel, and applied it to acute full-thickness skin defect wounds in rats to observe its role in wound healing. The results show that the slow-sculpting GO/alginate gel has excellent plasticity and is suitable for a variety of irregularly shaped wounds. At the same time, its porous structure and water content can maintain the activity of platelets and their released growth factors in PRP, thereby promoting wound collagen synthesis and angiogenesis to accelerate wound healing. This indicates that the slow-sculpting GO/alginate gel is an excellent loading material for PRP, and the combination of the two may become one of the methods to promote wound repair.