bluuebunny/crossref_metadata_2025 huggingface dataset:
The Pattern of Cardiovascular Disease Risks Among Working People (18-64 Years) via a Nationwide Household-Based Survey in Malaysia
Authors: Awaluddin S Maria , Lin Chong Zhuo , Kuay Lim Kuang , Shawaluddin Nor Syaqilah , Lah Tuan Amin Tuan , Robat Rosnawati Muhamad , Mahjom Maznieda , Yussof Muhammad Fadhli Mohd
Published: March 2022

Background
Cardiovascular diseases (CVDs) is prevalent globally and it is increasing tremendously. The article aimed to determine the prevalence and the odds ratio of seven type of diseases/ risk factors which contribute to CVDs among working people (18–64 years) in Malaysia.
Methods
A cross-sectional study among a nationally representative sample in Malaysia was conducted using a validated questionnaire. Clinical procedures were done by registered nurses to measure glucose, cholesterol, body mass index and blood pressure. The prevalence and prevalence odds ratio were calculated via complex samples data analysis of IBM SPSS Statistics version 25.
Results
The overall prevalence of CVD risks among working people were 14.1%, 17.3%, 24.5%, 28.8%, 31.7%, 45.9% and 94.2%, for diabetes, obesity, hypertension, physically inactive, tobacco smoker, hypercholesterolemia and inadequate fruit and vegetable (FV) intake, respectively. This study found that older age was associated with the odds of having the most CVD risks. Males were associated with higher odds of having hypertension and tobacco smoker, whereas females were more likely to have hypercholesterolemia, obesity, and physical inactivity. Those who worked as the manager & senior officials, clerical workers and services & sales workers were physically inactive while workers from the lower educational level were more likely to smoke tobacco. Workers in public sector were more likely to have a higher prevalence of diabetes, hypertension, hypercholesterolemia, smoking and obesity than workers in private sector.
Conclusions
This study highlighted that working people have significant CVD risks and the best intervention should be conducted at workplace settings.
Predicting Early Failure of Quantum Cascade Lasers During Accelerated Burn-in Testing Using Machine Learning
Authors: Aydinkarahaliloglu A. Cagri , Jatar Shashank , Wang Xiaojun , Fong Mary , Gupta Vijay , Troccoli Mariano , Hoffman Anthony J.
Published: March 2022

Device life time is a significant consideration in the cost of ownership of quantum cascade lasers (QCLs). The life time of QCLs beyond an initial burn-in period has been studied previously; however, little attention has been given to predicting premature device failure where the device fails within several hundred hours of operation. Here, we demonstrate how standard electrical and optical device measurements obtained during an accelerated burn-in process can be used in a simple support vector machine to predict premature failure with high confidence. For every QCL that fails, at least one of the measurements is classified as belonging to a device that will fail prematurely—as much as 205 hours before the actual failure of the device. Furthermore, for devices that are operational at the end of the burn-in process, the algorithm correctly classifies all the measurements. This work will influence future device analysis and could lead to insights on the physical mechanisms of premature failure in QCLs.
A randomized, double-blind, placebo-controlled 12-Week trial of Infliximab in patients with Juvenile-Onset Spondyloarthritis or Enthesitis Related Arthritis
Authors: Burgos-Vargas Rubén , Loyola-Sanchez Adalberto , Ramiro Sofia , Reding-Bernal Arturo , Gutiérrez-Suárez Raul , Casasola-Vargas Julio C. , Alvarez-Hernandez Everardo , Heijde Désirée Van der , Vazquez-Mellado Janitzia
Published: March 2022

Objective. To assess the efficacy and safety of infliximab versus placebo in the treatment of patients with Juvenile-onset Spondyloarthritis and enthesitis-related arthritis (JoSpA/ERA). Methods. Phase III, randomised, double-blind, placebo-controlled-trial of 12-weeks that included patients <18-year-old with JoSpA/ERA not-responding to nonsteroidal-anti-inflammatory drugs, sulfasalazine, or methotrexate. Patients were randomly assigned 1:1 to the infusion of Infliximab 5mg/kg or placebo; completers entered then an open-label extension (OLE) period of 42 weeks. The primary endpoint was the number of active joints. Secondary outcomes included the assessment of disease activity, tender entheses, spinal mobility, serum C reactive protein (CRP), the Bath Ankylosing Spondylitis Disease Activity and Functional Index, and the Childhood Health Assessment Questionnaire (CHAQ). Results. We randomized 12 patients to Infliximab and 14 to placebo. No significant differences were found between groups at baseline. At week 12, the mean number of active joints was 1.4 (SD 2.4) in the Infliximab group and 4.1 (SD 3.0) in the placebo group (p=0.0002). A repeated measures mixed model analysis that included all endpoints in the study demonstrated sustained favourable outcomes of Infliximab for active joints, tender joints, swollen joints and tender entheses counts, as well as for CHAQ and CRP (p<0.01). Adverse events were more frequent in the Infliximab group, including infections and infusion reactions, but none of them were serious.Conclusion. Infliximab is efficacious for patients with JoSpA/ERA with an inadequate response to conventional treatment. No serious adverse events with the use of infliximab were observed.
Investigating the Representation of Heatwaves from an Ensemble of Km-scale Regional Climate Simulations within CORDEX-FPS Convection
Authors: Sangelantoni Lorenzo , Sobolowski Stefan , Lorenz Torge , Hodnebrog Øivind , Cardoso Rita Margarida Cardoso , Soares Pedro , Ferretti Rossella , Lavín-Gullón Alvaro , Fernandez Jesus , Goergen Klaus , Milovac Josipa , Katragkou Eleni , Kartsios Stergios , Coppola Erika , Pichelli Emanuela , Adinolfi Marianna , Mercogliano Paola , Berthou Ségolène , de Vries Hylke , Dobler Andreas , Belušić Danijel , Feldmann Hendrik , Tölle Merja , Bastin Sophie
Published: March 2022

Heatwaves (HWs) are high-impact phenomena that stress both societies and ecosystems. Their intensity and frequency are expected to increase in a warmer climate over many regions of the world. While these impacts can be wide ranging, they are potentially influenced by local to regional features such as topography, land-cover, urbanization. Here, we leverage recent advances in the very high resolution modelling required to elucidate the impacts of heatwaves at these fine scales. Further we aim to understand how the new generation of km-scale regional climate models (RCMs) modulates the representation of heatwaves over a well-known climate change hot spot. We analyze an ensemble of 15 convection-permitting regional climate model (CPRCM, ~ 2–4 km grid spacing) simulations and their driving, convection-parameterized regional climate model (RCM, ~ 12–15 km grid spacing) simulations from the CORDEX Flagship Pilot Study on Convection. The focus is on the evaluation experiments (2000–2009) and three subdomains with a range of climatic characteristics. During HWs, and generally in summer season, CPRCMs exhibit warmer and drier conditions than their driving RCMs. Higher maximum temperatures arise due to an altered heat flux partitioning, with daily peaks up to ~ 150 W/m2 larger latent heat in RCMs compared to the CPRCMs. This is driven by a 5–25% lower soil moisture content in the CPRCMs, which is in turn related to longer dry spell length (up to double). It is challenging to ascertain whether these differences represent an improvement. However, a distribution-based maximum temperature evaluation, suggests that this CPRCMs warmer/drier tendency is likely more realistic compared to the RCMs, with ~ 70% of reference sites indicating an added value compared to the driving RCMs. Certainly, CPRCMs enhance dry conditions, with knock-on implications for summer season temperature overestimation, especially over flat terrains. Whether this improved physical representation of HWs also has implications for future changes is under investigation.
Citric acid production by a novel autochthonous Candida zeylanoides isolate: Optimization of process parameters
Authors: BÖREKÇİ BILGE SAYIN , Kaya Mükerrem , Göksungur Yekta , Kaban Güzin
Published: March 2022

In this study, citric acid production by autochthonous Candida zeylanoides 7.12 was investigated and optimized. Response surface methodology (RSM) was used for the analysis of simultaneous effects of the chosen factors and two experiment designs were applied. In the first experimental design, the effects of initial pH value (5.5-6.5), fermentation time (4-6 days) and initial glucose concentration (125-175 g/L) on citric acid production were investigated. Initial pH value was adjusted periodically with NaOH. Results of the statistical analysis showed that the model was found to be not applicable sufficiently to the chosen data. A second experimental design was employed by keeping the pH constant at pH 6.5 using glucose concentration and fermentation time as the process parameters to be optimized. Results of the statistical optimization showed that the fit of the model was good and the lack of fit was not significant at the 5 % (P<0.05). The highest citric acid concentration of 11.36 g/L was obtained after 6 days of fermentation with an initial glucose concentration of 125 g/L. The results indicated that initial glucose concentration and fermentation time were important parameters for citric acid production by C. zeylanoides 7.12 and this strain could be used for future studies.
Vancomycin-conjugated polydopamine-coated magnetic nanoparticles for molecular diagnostics of Gram-positive bacteria in whole blood
Authors: Abafogi Abdurhaman Teyib , Wu Tepeng , Lee Daekyu , Lee Jinyeop , Cho Gyoujin , Lee Luke P. , Park Sungsu
Published: March 2022

Sepsis is caused mainly by infection in the blood with a broad range of bacterial species. It can be diagnosed by molecular diagnostics once compounds in the blood that interfere with molecular diagnostics are removed. However, this removal relies on ultracentrifugation. Immunomagnetic separation (IMS), which typically uses antibody-conjugated silica-coated magnetic nanoparticles (Ab-SiO2-MNPs), has been widely applied to isolate specific pathogens in various types of samples, such as food and environmental samples. However, its direct use in blood samples containing bacteria is limited due to the aggregation of SiO2-MNPs in the blood and inability to isolate multiple species of bacteria causing sepsis. Results: In this study, we report the synthesis of vancomycin-conjugated polydopamine-coated (van-PDA-MNPs) enabling preconcentration of multiple bacterial species from blood without aggregation. The presence of PDA and van on MNPs was verified using transmission electron microscopy, X-ray photoelectron spectroscopy and energy disruptive spectroscopy. Unlike van-SiO2-MNPs, van-PDA-MNPs did not aggregate in the blood. Van-PDA-MNPs were able to preconcentrate several species of Gram-positive bacteria in the blood, lowering the limit of detection (LOD) to 10 colony forming units/mL by polymerase chain reaction (PCR) and quantitative PCR. This is 10 times more sensitive than the LOD obtained by PCR and qPCR with the use of van-SiO2-MNPs. Conclusion: These results suggest that PDA-MNPs do not aggregate in blood and can be conjugated with receptors, thereby improving the sensitivity of molecular diagnostics for bacteria in blood samples.
An Immune-Related Clinical-Gene-Risk-Score (CGRS) Prognosis Model for Bladder Cancer
Authors: Liu Sanhe , Duan Liqun , Wang Yiqi , Cui Diansheng , Deng Kangli , Wei Shaozhong , Dong Zhiqiang
Published: March 2022

Immunotherapy for bladder cancer is prevalent, while the efficacy is uncertain. To predict the outcomes of immunotherapy in bladder cancer patients, we had delineated the landscape of the tumor immune microenvironment based on two independent public databases, classified the bladder cancers in the training cohort as well as the validating cohort into the immune high and immune low subtypes, and identified 23 differentially expressed immune-related genes between the two subtype patients to build a prognostic gene risk score model. We further combined the model with other clinicopathologic signatures to develop a Clinical-Gene-Risk-Score (CGRS) prognosis model and validations of the two models in independent cohorts revealed good accuracy. Our model could provide prognostic indicators and potential immunotherapeutic targets for bladder cancers.
Microbiome analysis of bile samples in patients with choledocholithiasis and hepatobiliary disorders
Authors: Azimirad Masoumeh , Sadeghi Amir , Hosseinkhan Nazanin , Mirbagheri Seyedeh Zohre , Alebouyeh Masoud
Published: March 2022

Involvement of bacteria in the pathogenesis of biliary tract is largely unknown. In this study, we investigated differences in the microbiota of biliary tissue among adult patients with choledocholithiasis during endoscopic retrograde cholangiography (ERCP). 16S rDNA sequencing of bile samples, culture, and data of the medication history, underlying diseases and liver function tests were used for interpretation of differences observed in composition of bacterial taxa detected in the patients. The most common phyla found among the bile samples were included Proteobacteria, Firmicutes, Actinobacteria, Bacteroidetes, Cyanobacteria/Chloroplast, Fusobacteria, Acidobacteria, and Deinococcus-Thermus. Infection with anaerobic and microaerophilic bacteria showed host specificity, where Fusobacter, Prevotella, Veillonella, Propionibacter, Gemella, and Helicobacter coexist in same patients. Coexistence of anaerobic bacteria was mainly limited to patients with pancreatic cancer. Clostridium and Peptoclostridium spp. were detected in 80% and 86% of the patients, where highest relative abundance rates were detected in patients with elevated ALP levels and leukocytosis, respectively. Patients with leukocytosis presented higher rates of colonization with Pseudomonas, Cronobacter, Enterococcus, Klebsiella, Peptoclostridium, and Streptocossus. H. pylori was detected in 4 patients with and 1 patient without CBD stone. Higher diversity in the bacterial population was detected in patients with CBD stone compared with those lacking the stone, as richness of an unclassified member of Alphaproteobacteria, plus Helicobacter, Enterobacter/Cronobacter spp., Sphingomonas, Prevotella, Fusobacterium and Aeromonas were detected. Further studies are needed to show impact of these bacteria in human health or diseases through their interaction with host and virulence potential.
Integrative investigation of root-related mRNAs, lncRNAs and circRNAs of ‘Muscat Hamburg’ (Vitis vinifera L.) grapevine in response to root restriction through transcriptomic analyses
Authors: Liu Jingjing , Li Hui , Zhang Lipeng , Song Yue , He Juan , Xu Wenping , Ma Chao , Ren Yi , Liu Huaifeng
Published: March 2022

Background
Root restriction is a physical and ecological cultivation mode which restricts plant roots into a limited container to regulate vegetative and reproduction growth by reshaping root architecture. However, little is known about related molecular mechanisms. To uncover the root-related regulatory network of endogenous RNAs under root restriction, transcriptome-wide analyses of mRNAs, long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) involved in root development was performed.
Results
In this study, a total of 26588 mRNAs, 1971 lncRNAs and 2615 circRNAs were identified in root of annual ‘Muscat Hamburg’ grapevine by the next generation sequencing, respectively. The expression profile of mRNAs, lncRNAs and circRNA were further confirmed by the quantitative real-time PCR (qRT-PCR). Gene ontology enrichment analysis showed that a majority of the differentially expressed mRNAs, lncRNAs and circRNAs were annotated to the categories of cellular process, metabolic process, cell part, binding and catalytic activity. In addition, the regulatory network of endogenous RNAs was then constructed by the prediction of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA, implying that these RNAs play significant regulatory roles for root architecture shaping in response to root restriction.
Conclusion
Our results, for the first time, integrated the regulatory network of competitive endogenous RNAs (ceRNAs) functions of lncRNA and circRNA, and provided a basis for studying the potential functions of non-coding RNAs during root development of grapevine.
The Therapeutic Process – Client's Perception Of Success Promoting Factors In An And Arfid – Qualitative Study
Authors: Neiva Susana Maria Fernandes da Silva Albuquerque
Published: March 2022

This study aimed to analyze the perception that individuals have of the success promoting factors on their own therapeutic process. Intended to understand which aspects influenced their perception and which factors were considered relevant to the decision to seek help, not to abandon treatment and their motivation to change. The study involved patients with Anorexia Nervosa (AN) and Avoiding Food Intake Disorder (ARFID), with intervention within the scope of different therapeutic models.Background: In Portugal, anorexia nervosa is one of the eating disorders with a significant increase in recent years, having been responsible for 4,485 hospitalizations between 2000 and 2014, in Portuguese public health services. Portugal has scarce research in eating disorders although they are a serious mental health problem both in this country as in Europe. Methods: The study included a sample of 9 participants who responded to the request for participation posted on the different electronic platforms. The data recollection occurred thought a semi-structured interview and the information was subjected to thematic analysisResults: This study included a total of 9 participants, 5 with a diagnose of AN and 4 with a diagnose of ARFID. All the participants were women with ages between 19 and 52 years of age (an average of 38.4 years). Similarities were found in both group for and differences.Discussion: The desire to improve/not cause suffering to family members and the availability of social/emotional support were considered relevant aspects inherent to the client. 100% of the participants considered that certain professional and personal qualities of the professional/therapist was the most relevant aspect to promote the success of the therapeutic intervention. The sample size of this study is small and therefore does not allow generalizations.Conclusions: The main objective of this study was to obtain knowledge that would allow professionals to reflect on their practice and adapt the intervention to the needs and concerns of the clients. Despite the limitations of the study, our participants provided detailed and relevant information, so we consider the results obtained to be pertinent for the proposed objective. Further research in these areas is needed to deepen the knowledge.
Sex Differences in the Prevalence and Clinical Correlates of Suicidal Ideation in Adolescent Patients with Depression in a Large Sample of Chinese
Authors: Wu Jinbo , Wang Xiaohong , Zheng Yue , Shi Jingjing , Liu Jiacheng , Yang Liying , Kang Chuanyi , Yang Wanqiu , Guan Tiefeng , Liu Sitong , Zhao Na
Published: March 2022

Background
Sex differences in depression have been well recognized. However, sex differences in suicidal ideation (SI) in adolescents have rarely been systematically studied. This large-scale sample explored the sex differences in the prevalence and related risk factors of SI in adolescent patients with depression.
Methods
1635 patients with depression were recruited. Demographic and clinical characteristics were collected. Suicidal ideation was assessed by an interview. Children's Depression Inventory (CDI) and Adolescent Self-Rating Life Events Check List (ASLEC) were used to evaluate depression and stressful life events.
Results
The prevalence of suicidal ideation in female patients (383/887, 43.18%) was significant higher than in male patients (242/748, 32.35%). There were sex differences in CDI, ASLEC, and all subscales of ASLEC in patients with and without SI. Correlation analysis showed that family depression history and less sleeping time were significantly associated with suicidal ideation in female patients, while the severity of depression and stressful life events were associated in both genders. Further logistic regression analysis indicated that the severity of depression and relationship problems were independent risk factors of suicidal ideation in both sexes; family depression and inadequate sleeping time were significantly associated with suicidal ideation in female patients.
Conclusions
Our findings show that there are significant sex differences in the risk and clinical correlations of suicidal ideation in adolescent depression patients. Suicidal ideation is more frequent in female patients and is associated with multiple factors in both genders.
Beta-naphthoflavone Regulates Inflammation and Coagulation of Sepsis by Raising Nrf2/Ho-1 and Involving AKT/NF-κB Signaling Pathways
Authors: Chen Wenjing , Zhang Xianwei , Ye Fanrong , Sun Yuanyuan , Zhou Hongmin , Lu Yilun , Fang Zhendong , Pan Lingling , Jiang Hao , Qian Songzan , Huang Yueyue , Yu Xueshu , Chen Zhiqiang , Pan Jingye
Published: March 2022

BACKGROUND During sepsis, macrophages are activated by various irritants, such as Gram-negative bacteria LPS, which leads to the transcription of inflammatory and coagulation factors, including iNOS,COX-2,IL-1β,TNF-α and TF,PAI-1.Although inflammatory responses play a key role in the host's defense against infection, overactivation of innate immune cells can lead to severe sepsis. In the course of sepsis development, a variety of factors induce inflammatory response while activating coagulation function. Activation of the coagulation system is considered to be a host immune response against infection, however, overactivation of coagulation can cause harm to the host body, resulting in sepsis induced coagulopathy (SIC).METHODSIn this study, we aimed to evaluate the anti-inflammatory and anticoagulatory effects of BNF on sepsis by constructing in vivo (cecal ligation and puncture (CLP)-induced sepsis) and in vitro (LPS-induced mouse macrophage RAW264.7) sepsis models; the mechanisms behind these effects were also studied. Various aspects of sepsis, including inflammation, coagulation, and lung function, were monitored in the sepsis models.RESULTS Results indicated that the administration of BNF in sepsis mice caused reduced expression of pro-inflammatory factors, inhibited activation of coagulation, and lesser lung damage. The levels of LPS-induced macrophages, which lead to inflammation and coagulation, were also reduced. These effects are caused by participation in the Akt/NF-κB/Nrf2/HO-1 signaling pathway.CONCLUSIONThe results demonstrated that BNF treatment reduced the inflammatory response and coagulation dysfunction caused by sepsis in in vivo and in vitro models.Thus, BNF can be adopted as a novel therapeutic option to reduce sepsis mortality;However, further clinical studies are needed to confirm these effects on human sepsis.
Quantitative Measurement of Inferior Patellar Mobility: Sex-based Differences and Relationship With the Restricted Knee Flexion Angle Due to Aging
Authors: Ohko Hiroshi , Ota Susumu
Published: March 2022

Objective: To develop quantitative inferior patellar mobility (IPM) measurement methods and clarify the relationship between IPM and the knee flexion angle in community-dwelling elderly women.Design: The study was performed from May 2015 to December 2017. The reference value and sex difference of IPM were evaluated in 205 healthy young adults (age: 19-21 years). Additionally, 128 healthy elderly women (age: 65-79 years) were recruited from the community to evaluate the relationship between IPM and knee flexion angle. IPMs was also compared between healthy elderly women and healthy young women. IPMs were measured objectively by using our specially designed patellofemoral arthrometer (PFA); patellar mobility was calculated by normalizing to body height. IPM reliability assessment was performed prior to all measurements. Results: The intraclass correlation coefficients for intratester and intertester reliabilities varied from 0.87 to 0.99. The normal range, based on 2 standard deviations, of inferior patellar displacement/body height was 5.9%–13.5% (young men), 5.1%–14.3% (young women), and 1.2%–8.8% (elderly women). The IPM was significantly lower in elderly women than in young women (P < 0.001). There was a significant positive correlation (r = 0.72, P < 0.01) between IPM and the knee flexion angle in healthy elderly women who were unable to fully flex the knee joint.Conclusions: Our PFA has good intratester and intertester reliability. The results suggest that IPM decreases with aging in women. IPM and the knee flexion angle are correlated among elderly women who are unable to fully flex the knee joint.
Treatment of steroid-dependent rectal sparing ulcerative colitis associated with severe autoimmune hemolytic anemia with oral mycophenolate mofetil--a case report and review of literature
Authors: Liu Xin , Sha Sumei , Xu Bin , Shi Haitao , Quan Xiaojing , Chen Fenrong , Jiang Jiong
Published: March 2022

Background: Patients with ulcerative colitis (UC) may experience various type of anemia, in which the most common reasons are dystrophic anemia and hemorrhagic anemia. Autoimmune hemolytic anemia (AIHA) associated with UC is seldom seen, especially Coombs-negative AIHA. Case presentation: Here we report a case of refractory anemia that cannot be explained by UC disease activity in a young male. The patient was infected with cytomegalovirus (CMV). Colonoscopy showed diffuse polypoid hyperplasia with the absence of rectal involvement. Although the UC was in remission from steroid or total enteral nutrition, but the anemia is getting worse. The Coombs test showed negative, who is subsequently diagnosed by warm autoantibodies of IgA type and treated with mycophenolate mofetil (MMF) 2g daily. Both UC and AIHA were improved from treatment.Conclusion: AIHA can be secondary to UC, infection, or drugs, in which IgA autoantibody AIHA is a special situation. When gastroenterologist and Immunologist, and hematologist encounter patients with "negative" Coombs test acquired hemolytic anemia, AIHA should be considered in the differential diagnosis. MMF may be an option for the treatment of UC patients with AIHA.
Enhanced Opto-Electronic Properties Of X-Doped (X=Al, Ga, And In) Cuo Thin Films For Photodetector Applications
Authors: Gnanasekar T. , Valanarasu S. , Das Himadri Tanaya , Chidhambaram N. , Isaac R.S. Rimal , Al-Enizi Abdullah M. , Ubaidullah Mohd , Reddy Vasudeva Reddy Minnam
Published: March 2022

Recent trends in optoelectronics still need a high efficient photodetector based on p-type metal oxide semiconductors. This work stands with the improvement in the performance of CuO thin films via doping with different metals into the thin films. The CuO thin films were successfully doped with 1 wt% of X (X=Al, Ga, and In) by spray pyrolysis technology. The prepared doped CuO thin films were characterized to interpret the structural, morphological, and elemental characteristics using advanced techniques. These doped CuO thin films were subjected to study the photodetection ability by analyzing optoelectronic properties. The doping also has tuned the optical and electrical properties. Among the fabricated photodetectors, the Al-doped CuO detector shows a maximum photocurrent. The CuO:Al(1.0%) thin film exhibits a high photocurrent of 2.59⨯10-6A, the responsivity of 2.82⨯10-1 AW-1, the external quantum efficiency of 66%, and detectivity of 1.45⨯1010 Jones. Compared to the other thin films, Al doping has remarkably reduced the bandgap and shows a good photosensing activity that may be due to an increase in charge carriers. These outcomes provide a way to assemble good photodetectors and tune their properties in a wide range.
Urban comprehensive carrying capacity and urbanization in Northeast China with urban shrinkage
Authors: Ren Wanxia , Xue Bing , Xie Xiao , Zhao Bingyu , Li Jingzhong , Han Bin
Published: March 2022

The scientific evaluation and identification of the relationship between urban comprehensive carrying capacity (UCC) and urbanization in Northeast China under serious urban shrinkage is an important basis for realizing the all-around revitalization of the region. Using a panel data set of 34 prefecture-level cities with six nonshrinking cities and 28 shrinking cities in Northeast China from 2003 to 2019, this study constructs an ordinary panel data model and a static and dynamic spatial econometric model, the spatial Durbin model (SDM), to identify the relationship between the UCC and urbanization and to empirically investigate the impacts of the key control variables on UCC improvement. The results show a significant U-shaped curve relationship between the UCC and urbanization for the shrinking cities and a significant inverted U-shaped curve relationship for the nonshrinking cities, and the spillover effect of the urbanization is not significant. Moreover, social urbanization has a significant negative spatial effect on the local and neighborhood UCC of the nonshrinking cities, while demographic and spatial urbanization have significant positive spatial effects on the local and neighborhood UCC of the shrinking cities. In addition, fixed asset investment significantly promotes the UCC of the nonshrinking and shrinking cities and has significant positive spillover effects on the neighboring regions. R&D investment has a significant positive spatial effect on only the local and neighborhood UCC of the shrinking cities, while it has a significant positive effect on only the local UCC of the nonshrinking cities. New-type urbanization, industrial structure adjustment, new infrastructure construction and technological innovation are effective measures for improving and enhancing the comprehensive carrying capacity of cities in Northeast China.
Research on Collapse Ultimate Load of Fabricated RCS Composite Frame Structure
Authors: Liu Youquan , Xiong Jingang , Wen Jiancong , Xiong Moqiang
Published: March 2022

In this paper for study the collapse ultimate load of the prefabricated reinforced concrete column—steel beam composite frame structure, the “new RCS beam-to-column joint” is used as the beam–to-column connection to the experimental model, the half-scale fabricated RCS space frame structure (2-story, 1×2 bay) is subjected to twice instantaneous failure experiments on the bottom of side column under different load levels. The 2A column is quickly pulled out by the traction force of the vehicle. The experimental results demonstrated that the method of dismantling the failure column can relatively truly response the progressive collapse condition. The remaining RCS structure is all in the elastic stage under twice different load level tests. The displacement time history curve has no vibration phenomenon in the first experimental. The SAP2000 finite element program is used to verify that the test results are basically the same as the numerical simulation results, and it is further explored that the collapse ultimate load value is 10.25 times of the structure design load value.
Determining the Recurrence of Diabetic Patients Recovery Time in Benishangul-Gumuz Hospitals, Ethiopia
Authors: Endalkachew  , Zelalem
Published: March 2022

Diabetes is a chronic, metabolic disease characterized by elevated levels of blood glucose (or blood sugar). About 90% of people with diabetes around the world have type II diabetes. It is the main global health issues and burden as well with serious health complications including heart disease, blindness, kidney failure, and lower-extremity amputations. In middle- and low-income countries the prevalence of diabetes has been rising more rapidly and needs great attention. The data from such case has been considered as recurrent event data and correlation between events should be taken into account in the analysis. Thus, the aim of the study was to identify risk factors for recurrence of diabetic patients recovery time in Benishangul-Gumuz hospitals (Assosa, Pawi and Wonbera hospital), Ethiopia. A retrospective study has been applied to obtain data on the recurrence of diabetic patient’s recovery time in Benishangul-Gumuz hospitals, Ethiopia, from September 1, 2019 to September 1, 2021. Kaplan-Meier plot (s) and Log-rank test were used for comparison of patients recovery time from diabetes; Standard Cox-PH and Shared Frailty model were used to identify factors signiﬁcantly affect the recovery time of diabetic patients, using R version 4.1.1 for data analysis. Of the total diabetic patients in this study 61.87 % experienced recurrence of diabetic. The estimated median recovery time of diabetic patient’s was 6 months. The Shared Log-normal Frailty model was chosen to be best fit for this data set, based on Likelihood Cross-Validation value. Family history, other medical history and Systolic Blood Pressure of patients were significantly affected the recovery time of diabetic patient’s.
Cluster Randomised Trials - Ivermectin Repurposing for Covid-19 Treatment of Outpatients with Mild Disease in Primary Health Care Centers
Authors: Chahla Rossana Elena , Ruiz Luis Medina , Mena Teresa , Brepe Yolanda , Terranova Paola , Ortega Eugenia Silvana , Barrenechea Guillermo Gabriel , Goroso Daniel Gustavo , de Bruno María de los Ángeles Peral
Published: March 2022

Background: The emergence of COVID-19 requires alternative treatments. This study aims to evaluate the therapeutic intervention with ivermectin in outpatients with COVID-19 mild disease, to increase discharge and prevent the progression to moderate or severe disease. Methods: Randomized Trial in an overall ratio 1:1, n = 254. The subjects were divided into experimental (EG: n = 110) and control groups placebo (CG: n = 144). The EG received ivermectin orally 0.6 mg/kg weight in two doses. All participants were by physical examination COVID-19 diagnosed with negative RT-PCR at the beginning and the end of protocol. Differences between the variables were determined using the Chi-square test (p<0.05). The contagion risk (Odds Ratio) was calculated using software STATA. Results: Both groups were similar in age, sex, and comorbidities. A significant reduction in the percentage of participants with symptoms (PPS) was observed in the EG and CG when the clinical evaluation of symptoms was performed from 5th to 9th (p= 0·0005). When the clinical evaluation was performed from 10th to 14th day there was no significant difference. A higher proportion of outpatient discharge was observed in EG (98·2%) vs. CG (86·1%) (p-Value = 0·0007). EG showed 8 times more chance of receiving discharge than CG (OR 8·71, 95% CI: 1·99 -38·12, p = 0·004). The treatment effect with ivermectin to obtain discharge from outpatient care was analyzed by the logistic regression. Then, the chance to obtain outpatient discharge was independent of variables sex, age, and comorbidities. Conclusion: Treatment with ivermectin in outpatients care with mild disease of COVID-19 managed to slightly reduce PPS. The treatment with ivermectin could significantly prevent the evolution to serious stages since the EG did not present any patient with referral to critical hospitalization. Retrospective Clinical Registration: ClinicalTrial.gov Identifier NCT04784481; Trial registrationdate: 03-05-2021. Last updated: 04-26-2021.
An Interpretive Descriptive Approach to Understanding Osteoporosis Management from the Perspective of People with Osteoporosis
Authors: Ziebart Christina , MacDermid Joy , Furtado Rochelle , Szekeres Mike , Suh Nina , Khan Aliya
Published: March 2022

Background: Adherence to both non-pharmacological and pharmacological fracture prevention interventions is often low in people with osteoporosis. Understanding how patients acquire information about osteoporosis management is important for understanding both the initial decision-making and ongoing adherence. This study explored the narrative of people living with osteoporosis and their personal experience getting information about their osteoporosis management. Methods: An interpretive descriptive method was used for this qualitative study. In-depth interviews were conducted with 13 Canadian participants (age range 51-90) who knew that they had osteoporosis or osteopenia. Participants were asked to participate in one-on-one interviews to address the type of health professionals providing osteoporosis management advice focusing specifically on advice received about exercise, nutrition, and falls prevention. Interviews were transcribed verbatim and coded sentence-by-sentence. Results: People with osteoporosis rely on physicians for advice related to pharmacological treatment needs, and other health professionals for non-pharmacological needs such as exercise advice, nutrition advice, and falls prevention advice. People value non-professionals, such as family members and close friends, who may or may not have osteoporosis, to discuss or corroborate health professional advice, or to validate their belief system. Conclusion: Training patients to more effectively engage in conversations with their healthcare providers may be a strategy to improve the quality of communication and its translation into adherence to best practices in managing osteoporosis.
Different Angular Kyphosis Locations Have Different Relative Positions of Aorta to Spine in Patients with Pott's Deformity
Authors: Jiang Heng , Liao Taotao , Lu Zhengyu , Wang Ce , Gao Rui , Ma Jun , Zhou Xuhui , Zhao Jianquan
Published: March 2022

Background. The position of the aorta relative to the spine in kyphosis secondary to ankylosing spondylitis is little understood. The purpose of this study was to investigate the anatomic relationship between the aorta and the spine in patients with Pott's deformity and to compare it with the normal people.Methods. Seventy-six patients with Pott's deformity (Group TB) and seventy-two age- and sex-matched patients with a normal spine (group NC) were enrolled in this study. The relative position of aorta to the spine was evaluated from T4 to L4 on the computed tomographic angiography scans for controls and at the apex level for TB patient, and was classified into 4 kinds of degrees. Results. The left pedicle-aorta angle in group TB was significantly larger than that in group NC at the T6-L3 levels. Group TB exhibited significantly smaller left pedicle-aorta distance, pedicular line-aorta distance and vertebra/rib-aorta distance than those in group NC at the T5-T10 levels, but bigger at the L1-3 levels. Patients with grade 3 and 4 aorta had more segments involved compared with those with grade 1 aorta. Patients with grade 2, 3, and 4 aorta showed larger kyphotic angles than those with grade 1.Conclusions. Patients whose morbid segments involved only thoracic vertebrae presented with an “Ω” shaped aorta in sagittal plane, and 4 different kinds of degrees of aorta relative to the vertebra/rib in axial plane. Patients whose morbid segments covered lumbar vertebrae presented with an “M” shaped aorta in sagittal plane, and the aorta shifted further from apex vertebra but was located in close proximity to the vertebral body at levels above and below the osteotomy levels in axial plane.
Hospice Care Providers’ Knowledge, Attitudes And Practices In China: A Cross-Sectional Study
Authors: Shu Zhiqun , Jing Limei
Published: March 2022

Background: In recently years, China has been growing awareness about the hospice service movement although hospice care was Initially introduced 30 years ago. Hospice care providers’ knowledge, attitudes, self-efficiency, and practices status in China should be investigated. This study aims to survey the general actuality of hospice care providers’ knowledge, attitudes, and practices of hospice care (KAPHC) in five cities in China, and explore relevant influencing factors.Method: Relying on our KAPHC scale, we randomly surveyed 3647 valid health care providers in five sampled cities of China in 2019, which respectively represent the north, northeast, east, central, and southwest area. In each city, 14 institutions were selected and 50 health providers were surveyed in each institution. Increment of voluntary participation was accepted. The scaling outcomes were compared among each sampled city-groups with Chi-square test or ANOVA. Multiple correspondence analyses were also performed for further results.Results: Of all, 41.46% providers had real experience in providing hospice care, and 58.68% confirmed willingness of providing. The overall knowledge correct rate was 57.13%. The average scores of threats, benefits, barriers, subjective norms, confidence, and self-report behaviour items were 15.40, 41.56, 16.75, 15.65, 41.56, and 38.61. Providers from eastern China, willing to provide hospice care, or experienced death witness in providing hospice care, proved better score in knowledge, threats, benefits, barriers, subjective norms, confidence, and self-report behaviour (P<0.05).Conclusions: The investigation reflected urgent need for systematic training of professional knowledge and skills on hospice care for health care providers. Governments’ attention and policy measures are crucial as most Chinese hospice care providers practiced as “organization actors”. More attention was need on balanced development of different areas.
Naringenin protects hepato-renal tissues against antituberculosis drugs induced toxic manifestations by modulating IL-6, IGF-1, CYP2E1, biochemical and ultra-structural integrity
Authors: Sahu Nisha , Rakshit Samrat , Nirala Satendra Kumar , Bhadauria Monika
Published: March 2022

The antituberculosis drugs (ATDs), isoniazid, rifampicin, pyrazinamide and ethambutol prompt extreme hepatic and renal damage during treatment of tuberculosis. The present study aimed to investigate protective potential of naringenin against ATDs induced hepato-renal injury. Rats were administered with ATDs orally for 8 weeks (3 days/week) followed by naringenin at three different doses (10, 20 and 40 mg/kg) conjointly for 8 weeks (3 days/week alternately to ATDs administration) and silymarin (50 mg/kg) as positive control. Exposure to ATDs caused significant increase in IL-6, triglycerides, cholesterol, bilirubin whereas depletion in IGF-1, albumin and glucose in serum. Endogenous antioxidants GR, GPx and G-6-PDH were diminished in liver and kidney tissues with parallel increase in triglycerides, cholesterol, microsomal LPO and aniline hydroxylase (CYP2E1 enzyme). Ultra-structural observations of liver and kidney showed marked deviation in plasma membranes of various cellular and sub-cellular organelles after 8 weeks of exposure to ATDs. Conjoint treatment of naringenin counteracted ATDs induced toxic manifestations by regulating IL-6, IGF-1, CYP2E1, biochemical and ultra-structural integrity in a dose dependent manner. Naringenin has excellent potential to protect ATDs induced hepato-renal injury by altering oxidative stress, modulation of antioxidant enzymes, serum cytokines and ultra-structural changes.
Rechtsextremes Framing auf YouTube
Authors: Heider Matthias
Published: March 2022

Die deutschsprachige rechtsextreme Szene ist auf YouTube aktiv. Rechtsextreme Influencerinnen und Influencer veröffentlichen regelmässig Videos, in denen sie politische Themen aufgreifen. Mit ihren Inhalten erreichen sie zum Teil hunderttausende Menschen. Dieser Beitrag analysiert anhand der Erkenntnisse der Framing-Theorie, die davon ausgeht, dass die Art, wie ein Ereignis beschrieben und dargestellt wird, Auswirkungen auf dessen Interpretation durch die Rezipierenden hat, fünf Videos von Produzierenden der rechtsextremen Identitären Bewegung mittels qualitativer Inhaltsanalyse. Dabei wird deutlich, dass sich die Produzierenden der gängigen Ästhetik der Plattform anpassen und dass die sich humoristischer Stilmittel bedienen, um ihre Inhalte weniger radikal wirken zu lassen. Ausserdem nutzen sie teilweise Ästhetiken und Strategien, die aus Nachrichtenformaten bekannt sind. So bedienen sie bekannte Sehgewohnheiten der Rezipierenden. Ausserdem erhalten die Videos so den Anschein, journalistisch recherchiert und belegt zu sein, obwohl dies nicht der Fall ist. Diese Ergebnisse bieten nicht nur einen Einblick in die Kommunikationsstrategien rechtsextremer Gruppierungen, sondern auch wichtige Anknüpfungspunkte für die praktische Arbeit gegen Rechts.
Choreografien vor den Überwachungskameras der Kleinstadt
Authors: Sterzenbach Barbara , Kranixfeld Micha , Waburg Wiebke
Published: March 2022

Im Jahr 2020 stellten die Künstlerinnen und Künstler Kılınçel & Schaper sich und der Kleinstadt Schotten die Aufgabe, ein Selfie zu produzieren, welches die Gemeinde abbilden sollte. Im Verlauf entstanden vielfältige Begegnungen und Kollaborationen mit der Bevölkerung, die schliesslich auf einer Website zu einer digitalen Assemblage zusammengefügt wurden. Der Beitrag kombiniert die Analyse des partizipativ hervorgebrachten digitalen Kunstwerks mit ethnografischen Beobachtungen des Produktionsprozesses, der ebenfalls auf verschiedenerlei Weise von Digitalität geprägt war. Dabei fokussieren die Autorinnen und Autoren auf die Arbeit mit Jugendlichen aus der Gemeinde. Im Rückgriff auf Machtbegriffe von Imbusch sowie Deleuze und Guattari wird untersucht, wie Selbstaufnahmen und digitale Assemblagen Machtfigurationen in ländlichen Räumen befragen und verschieben können. Es konnte herausgearbeitet werden, dass das partizipativ produzierte digitale Kunstwerk nicht ohne Blick auf die machtvollen sozialen Prozesse verstanden werden kann, die zu seiner Herstellung geführt haben. Dabei konnte aufgezeigt werden, dass sozialer und künstlerischer Prozess als gleichberechtigte Teile einer gegenseitigen kulturellen Bildung erscheinen, die Künstlerinnen, Künstler und Teilnehmende gemeinsam durchlaufen. Mit ihrer Arbeit agieren Kılınçel & Schaper temporär in einem lokalen Jugendzentrum und sind herausgefordert, sich innerhalb persönlicher, pädagogischer, machtvoller und machtkritischer sowie künstlerisch-ästhetischer Spannungsfelder zu verorten. Den Jugendlichen eröffnet sich mithilfe künstlerischer Verfahrensweisen, die digitalen und physischen Raum verbinden, ein erweitertes, kreatives Handlungsspektrum im Umgang mit der Überwachung ihrer Räume.
Analysis of the most effective cluster strategies implemented in circumpolar regions
Authors: Хаценко Е.С.
Published: March 2022

Представленная статья посвящена анализу функционирования и развития региональных отраслевых арктических кластеров, их влиянию на пространственное развитие Арктической зоны, осуществлен анализ направлений реализации региональной кластерной стратегии развития субъектов, осуществлена оценка кластерного потенциала отраслей экономики субъектов Арктической зоны.

The presented article is devoted to the analysis of the functioning and development of regional sectoral Arctic clusters, their impact on the spatial development of the Arctic zone, the analysis of the directions of implementation of the regional cluster strategy for the development of the subjects, the assessment of the cluster potential of the economic sectors of the subjects of the Arctic zone.