bluuebunny/crossref_metadata_2025 huggingface dataset:
Carotid-Vertebral or Carotid-Subclavian Transpositions in Supra-Aortic Steno-Occlusive Diseases When Endovascular Therapy Is Unfeasible or Unsuccessful
Authors: Wang Jian , Chu Jie , Zhang Lihua , Chen Juan , Zheng Yi , Sheng Shi , Jin Bi , Ouyang Chenxi , Li Yiqing
Published: October 2021

Background and purpose

Despite advances in endovascular therapies, some patients experience vertebral artery stenosis or subclavian artery occlusion and may not benefit from less-invasive angioplasty/stenting. This study described 4 cases in which carotid-vertebral transposition (CVT) or carotid-subclavian transposition (CST) was adapted when endovascular treatment was unfeasible or unsuccessful.

Presentation

Case 1: A 65-year-old woman presented with severe stenosis of the right vertebral artery ostium, dysplastic left vertebral artery, and aneurysmal dilatation of proximal right subclavian artery and brachiocephalic trunk. Case 2: A 23-year-woman had severe stenosis at the first portion of left vertebral artery caused by Takayasu's arteritis. Because endovascular intervention was unfeasible, CVTs were performed in cases 1 and 2. Case 3: A 73-year-old man presented with total occlusion of the proximal right subclavian artery and severe stenosis of the right internal carotid artery. Case 4: A 58-year-old man experienced complete occlusion of the left subclavian artery and severe stenosis of the left common carotid artery. Duplex ultrasonography showed reverse flow in the vertebral artery in keeping with vertebral steal syndrome. Endovascular treatment was unsuccessful because the wire did not cross the occlusion of the subclavian artery. CSTs were performed with concurrent ipsilateral carotid endarterectomy in cases 3 and 4.

Conclusion

The present case series demonstrated that CST and CVT were effective treatment modalities for subclavian or vertebral artery lesions. Although endovascular stenting and angioplasty have been advocated as first-line management, CST and CVT should be considered as the remedy when endovascular intervention is unsuccessful or unfeasible.
TOTEM E TABU: VIDA COTIDIANA
Authors: D’Almeida de Sousa Santana Bruno Wagner
Published: October 2021

No presente artigo o autor procura fazer um breve estudo do texto Totem e tabu: algumas concordâncias entre a vida anímica dos selvagens e a dos neuróticos, escrito por Freud em 1913. Destacando os principais pontos discutidos por Freud em cada capítulo da obra, o principal intento do autor é mostrar que ao contrário da interpretação que se costuma fazer, Freud não escreve esse texto para distanciar “primitivo” e “civilização”, como se fossem etapas maturacionais do processo do desenvolvimento humano, linearmente em ascensão evolutiva. A temporalidade que orienta Freud em Totem e tabu não busca distanciar “primitivo” e “civilizado”, busca antes aproximá-los, busca mostrar o que há neles de concordância, como fica explícito no próprio subtítulo da obra: algumas concordâncias entre a vida anímica dos selvagens e a dos neuróticos.PALAVRAS-CHAVE: Psicanálise. Totem. Temporalidade. Índios. Civilização.
Prevention set‐aside from SAPT BG accounts for almost all funding
Authors: Knopf Alison
Published: October 2021

At least 20% of the Substance Abuse Prevention and Treatment (SAPT) block grant, which goes to the states by formula, must be used for alcohol and drug prevention by each state under federal statute. As it turns out, many states rely on this money for 100%, or nearly 100%, of prevention funding.
Methamphetamine‐involved OD deaths almost tripled in 4 years
Authors: Knopf Alison
Published: October 2021

Between 2015 and 2019, methamphetamine‐involved overdose deaths nearly tripled, according to a study released last week by the National Institute on Drug Abuse (NIDA). The number of people who reported using methamphetamine did not increase at the same pace, but the study, published Sept. 22 in JAMA Psychiatry, suggested that changes in patterns of use, and populations who use methamphetamine, have become riskier.
Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration
Authors: Mokhtari‐Farsani Abbas , Hasany Masoud , Lynch Iseult , Mehrali Mehdi
Published: October 2021

It has been over a decade since oxidative enzymes were first used to degrade carbon‐based nanomaterials (CBNs). Although enormous progress has been achieved in this field, many questions and problems remain unresolved that need to be answered to usher these materials toward their true destiny. Nanobioscience researchers now know that ignoring the biomolecular corona (BMC) in nanobiomedical studies, either inadvertently or intentionally, is by no means justified. However, a major drawback to progress is that BMC effects on CBN biodegradation have been omitted from a large number of studies. What's more, many studies in the field have eliminated the BMC source in the relevant experiments. Thus, the most critical question that one needs to probe is whether the BMC and its characteristics affect the biodegradability of CBNs? In this conceptual perspective paper, recent progress and significant research in CBNs biodegradation are summarized. Then, the importance of the BMC and its possible impacts on the biodegradation of CBNs are thoroughly explored as a conceptual guide. Finally, remaining challenges and the direction of future research are provided, and barriers that need to be overcome to advance the field are discussed including recommendations regarding BMC considerations and study design and reporting guidelines.
Synergistic Effect of Multi‐Walled Carbon Nanotubes and Ladder‐Type Conjugated Polymers on the Performance of N‐Type Organic Electrochemical Transistors
Authors: Zhang Silan , Massetti Matteo , Ruoko Tero‐Petri , Tu Deyu , Yang Chi‐Yuan , Liu Xianjie , Wu Ziang , Lee Yoonjoo , Kroon Renee , Persson Per O. Å. , Woo Han Young , Berggren Magnus , Müller Christian , Fahlman Mats , Fabiano Simone
Published: October 2021

Organic electrochemical transistors (OECTs) have the potential to revolutionize the field of organic bioelectronics. To date, most of the reported OECTs include p‐type (semi‐)conducting polymers as the channel material, while n‐type OECTs are yet at an early stage of development, with the best performing electron‐transporting materials still suffering from low transconductance, low electron mobility, and slow response time. Here, the high electrical conductivity of multi‐walled carbon nanotubes (MWCNTs) and the large volumetric capacitance of the ladder‐type π‐conjugated redox polymer poly(benzimidazobenzophenanthroline) (BBL) are leveraged to develop n‐type OECTs with record‐high performance. It is demonstrated that the use of MWCNTs enhances the electron mobility by more than one order of magnitude, yielding fast transistor transient response (down to 15 ms) and high μC* (electron mobility × volumetric capacitance) of about 1 F cm−1 V−1 s−1. This enables the development of complementary inverters with a voltage gain of >16 and a large worst‐case noise margin at a supply voltage of <0.6 V, while consuming less than 1 µW of power.
A Low Strain A‐Site Deficient Perovskite Lithium Lanthanum Niobate Anode for Superior Li+ Storage
Authors: Xiong Xuhui , Yang Liting , Liang Guisheng , Wang Chao , Chen Guanyu , Yang Ziqi , Che Renchao
Published: October 2021

The oxide perovskite family holds great promise for diverse applications on account of their unique chemical and physical properties. However, owing to the inadequate Li+‐storage sites, the insertion‐type perovskite anodes for lithium‐ion batteries (LIBs) are limited. A‐site deficient perovskites with rich intrinsic vacancies and ion transport channels are believed to be the desirable hosts of superior Li+ storage. Herein, the perovskite Li0.1La0.3NbO3 (LLNO) is designed and demonstrated as the remarkable anode for LIBs with a high specific capacity, a safe operating voltage, an excellent rate performance, and a long cycling life. More importantly, the outstanding cycling stability of LLNO is originated from its low strain characteristic with a maximum volume change of only 1.17%. The exceptional rate performance can be explained by the unconventional Li+ transport pathways with external → grain boundaries → lattice deficiencies. These results not only reveal that A‐site deficient perovskite LLNO is a promising anode for LIBs but also provide fundamental insights into the Li+ ions transport mechanism, facilitating the development of high‐performance perovskite anodes.
High‐Purity Monochiral Carbon Nanotubes with a 1.2 nm Diameter for High‐Performance Field‐Effect Transistors
Authors: Li Yahui , Zheng Miaomiao , Yao Jian , Gong Wenbin , Li Yijun , Tang Jianshi , Feng Shun , Han Ruyue , Sui Qicheng , Qiu Song , Kang Lixing , Jin Hehua , Sun Dongming , Li Qingwen
Published: October 2021

Monochiral single‐walled carbon nanotubes (SWCNTs) are promising materials with potential applications in 3D integrated circuits and optoelectronic hybrid circuits. However, the purity and device performance of monochiral SWCNTs are still far lower than expected. Here, the authors demonstrate that specific monochiral SWCNTs can be wrapped by conjugated polymers containing pyridine units, and the supramolecular assemblies show surprising suspension stability even after high‐intensity ultracentrifugation. Additionally, two novel methods are developed, namely, enhanced ultracentrifugation (E‐UCG) and stepwise extraction processing (STEP), which successfully achieve isolation of (10,8) and (12,5) SWCNTs with respective diameters of 1.24 and 1.2 nm at high monochiral purity (92.3% and 95.6%). Their S11 absorption and fluorescence emission peaks are both at ≈1.5 µm (optical telecommunications C‐band). Both micro‐ and nanoscale field‐effect transistor (FET) devices can be fabricated from the as‐isolated (10,8) SWCNTs, and these FETs exhibit excellent electrical performance and a high semiconducting purity of up to 99.94%.
From Glutinous‐Rice‐Inspired Adhesive Organohydrogels to Flexible Electronic Devices Toward Wearable Sensing, Power Supply, and Energy Storage
Authors: Zhou Hongwei , Lai Jialiang , Zheng Bohui , Jin Xilang , Zhao Guoxu , Liu Hanbin , Chen Weixing , Ma Aijie , Li Xusheng , Wu Yuanpeng
Published: October 2021

Flexible electronic devices (FEDs) based on hydrogels are attracting increasing interest, but the fabrication of hydrogels for FEDs with adhesiveness and high robustness in harsh‐temperature conditions and long‐term use remains a challenge. Herein, glutinous‐rice‐inspired adhesive organohydrogels are developed by introducing amylopectin into a copolymer network through a “one‐pot” crosslinking procedure in a glycerol–water mixed solvent containing potassium chloride as the conductive ingredient. The organohydrogels exhibit excellent transparency (>90%), conductivity, stretchability, tensile strength, adhesiveness, anti‐freezing property, and moisture retention ability. The wearable strain sensor assembled from the organohydrogels achieves a wide working range, high sensitivity (gauge factor: 8.82), low response time, and excellent reversibility, and properly responds in harsh‐temperature conditions and long‐time storage (90 days). The strain sensor is further integrated with a Bluetooth transmitter and receiver for fabricating wireless wearable sensors. Notably, a sandwich‐structured capacitive pressure sensor with organohydrogels containing reliefs as electrodes records a new gauge factor of 9.43 kPa−1 and achieves a wide response range, low detection limit, and outstanding reversibility. Furthermore, detachable and durable batteries and all‐in‐one supercapacitors are also fabricated utilizing the organohydrogels as electrolytes. Overall, this work offers a strategy to fabricate adhesive organohydrogels for robust FEDs toward wearable sensing, power supply, and energy storage.
Low‐Energy Oxygen Plasma Injection of 2D Bi2Se3 Realizes Highly Controllable Resistive Random Access Memory
Authors: Yin Chujun , Gong Chuanhui , Tian Siying , Cui Yi , Wang Xuepeng , Wang Yang , Hu Zhenheng , Huang Jianwen , Wu Chunyang , Chen Bo , Wang Xianfu , Li Chaobo
Published: October 2021

Resistive random access memory (RRAM) based on ultrathin 2D materials is considered to be a very feasible solution for future data storage and neuromorphic computing technologies. However, controllability and stability are the problems that need to be solved for practical applications. Here, by introducing a damage‐less ion implantation technology using ultralow‐energy plasma, the transport mechanisms of space charge limited current and Schottky emission are successfully realized and controlled in RRAM based on 2D Bi2Se3 nanosheets. The memristors exhibit stable resistive switching behavior with a high resistive switching ratio (>104), excellent cycling endurances (300 cycles), and great retention performance (>104 s). The reliability and controllability of Bi2Se3 memory endowed by oxygen plasma injection demonstrate the great potential of this ultralow‐energy ion implantation technology in the application of 2D RRAM.
Sn Alloying to Inhibit Hydrogen Evolution of Zn Metal Anode in Rechargeable Aqueous Batteries
Authors: Wang Luyao , Huang Weiwei , Guo Wenbin , Guo Zi Hao , Chang Caiyun , Gao Lei , Pu Xiong
Published: October 2021

The detrimental hydrogen evolution side reaction is one of the major issues hindering the commercialization of Zn metal anode in high‐safety and low‐cost rechargeable aqueous batteries. Herein, the authors present a Sn alloying approach to effectively inhibit the hydrogen evolution and dendrite growth of the Zn metal anode. Through in situ monitoring of the hydrogen production during repeated plating/stripping tests, it is quantitatively demonstrated that the hydrogen evolution of alloy electrode with appropriate Sn amount is only half of that of pure Zn electrode. Furthermore, the Sn alloying allows for favorable Zn nucleation sites, lowering the Zn nucleation energy barrier and promoting more uniform Zn deposition. The Zn‐Sn alloy electrode offers much‐improved plating/stripping cycling, that is, over 240 h at 5 mA cm−2 and 35.2% depth of discharge. This work provides a practically viable strategy to stabilize Zn metal electrode in rechargeable aqueous batteries.
Tumor Diagnosis and Therapy Mediated by Metal Phosphorus‐Based Nanomaterials
Authors: Liu Yang , Wang Yinghui , Song Shuyan , Zhang Hongjie
Published: October 2021

Metal phosphorus‐based nanomaterials (Metal‐P NMs) including metal phosphate nanomaterials, metal phosphide nanomaterials, and metal‐black phosphorus (Metal‐BP) nanocomposite are widely used in the field of biomedicine owing to their excellent physical and chemical properties, biocompatibility, and biodegradability. In recent years, metal phosphate nanomaterials and Metal‐BP nanocomposite acted as medicine delivery system have made breakthroughs in tumor diagnosis including magnetic resonance imaging, fluorescence imaging, photoacoustic imaging, nuclear imaging, and therapies including chemotherapy, gene therapy, photothermal therapy, photodynamic therapy, and radiation therapy. Metal phosphate nanomaterials have good biodegradability, especially calcium‐based metal phosphate nanomaterials can be dissolved into nontoxic ions and participate in the metabolisms of normal organs. Compared with metal phosphate nanomaterials, metal phosphide nanomaterials have excellent optical, magnetic, and catalytic properties, which can be used as multifunctional diagnostic nanoplatforms and therapeutic agents for chemodynamic therapy, photothermal therapy, or immunotherapy. The latest developments in Metal‐P NMs, covering the range of preparation methods and biological applications, such as serving as drug carriers, tumor diagnosis, and therapy, are focused. All in all, the current trends, key issues, future prospects and challenges of Metal‐P NMs are concluded and discussed, which are important for the development of this research field and shining more lights on this direction.
Co‐Electrodeposition of Nanostructured Ce‐NiOx on Stainless‐Steel Substrates for the Oxygen Evolution Reaction under Alkaline Conditions
Authors: Swarnkar Priyanka , Sarfo Daniel K. , Pannu Amandeep Singh , Rainey Thomas , Sundararajan Thirumalachari , O'Mullane Anthony P.
Published: October 2021

The development of cost‐effective catalysts that can be fabricated at scale for electrochemical water oxidation is an ongoing challenge. Here it is shown that stainless‐steel AISI316 is an appropriate support electrode for a co‐electrodeposited Ni‐CeOx catalyst for the oxygen evolution reaction (OER) under alkaline conditions. Optimal OER performance is achieved via a cyclic voltammetric deposition protocol rather than constant potential deposition for the catalyst layer. An overpotential of 300 mV at a current density of 10 mA cm−2 is recorded with a Tafel slope of 43 mV dec−1 while the catalyst also demonstrates long‐term stability. It is also found that the catalyst layer changes significantly after the OER. This includes changes to the catalyst morphology, distribution of oxidation state, and speciation as well as the transformation from an entirely amorphous material into one containing crystalline regions. This simple one‐step electrodeposition process on a cost‐effective substrate should, in principle, facilitate the fabrication of low‐cost electrolyzers.
Sacrificial 3D Printing of Highly Porous, Soft Pressure Sensors
Authors: Alsharari Meshari , Chen Baixin , Shu Wenmiao
Published: October 2021

Additive manufacturing (AM) technologies offer the possibilities of rapid prototyping, novel and innovative geometrical freeform 3D designs. Recent progress in AM has proved its potential to facilitate the fabrication of multi‐material innovative sensing devices for wearable soft electronics. Extrusion based 3D printing such as fused deposition modeling FDM is gaining popularity in academic research due to availability, affordability, the ability to be modified, simultaneous multi‐material fabrication, ease of material adaption, and development. Herein, a method of fabricating soft compressible multi‐layered pressure sensors via FDM 3D multi‐material printing is presented. Highly sensitive and tunable pressure sensors are realized with enhanced compressibility and wide sensing range. The electromechanical properties of the 3D printed sensors are investigated throughout this paper. The 3D printed pressure sensors demonstrate high tactile sensitivity reaching 0.7145 kPa−1at 0.5 kPa. Cyclic testing of the multi‐layered sensor shows linear and reproducible response with wide range sensitivity that suggests their great potential in wearable and robotic applications.
Post‐Illumination Photoconductivity Enables Extension of Photo‐Catalysis after Sunset
Authors: Loh Joel Y. Y. , Sharma Geetu , Kherani Nazir P. , Ozin Geoffrey A.
Published: October 2021

Cloud‐cover‐induced frequent and sharp dips in sunlight as well as diminished solar flux during the evenings of peak energy demand are major challenges in solar energy harvesting. Persistent and memory‐based photocatalysts that efficiently operate under low light fluxes beyond sunset, are a potential solution to address and mitigate these challenges. This review describes examples of persistent photocatalysis systems based on charge injection into multivalent charge storage materials that allow post‐illumination discharging and charge carrier generation that increase or maintain the catalysis rate. Persistent photocatalysis in defect‐laden charge storage materials with multivalent states combined with slow charge release associated with electronic persistent photoconductivity results in giant persistent photocatalysis that can last more than an hour after the illumination is shut off. Strategies are suggested to develop persistent photocatalysis by improved charge separation and present figures of merit for evaluating persistent photocatalysis efficiency and performance. Furthermore, this could enable the use of such material systems in environmental applications such as photocatalytic coatings for the remediation of air pollution that continue to function into the night and self‐cleaning applications that continue to disinfect during the night.
Reimagining the eg1 Electronic State in Oxygen Evolution Catalysis: Oxidation‐State‐Modulated Superlattices as a New Type of Heterostructure for Maximizing Catalysis
Authors: Ding Ran , Yasini Parisa , Peng Haowei , Perdew John P. , Borguet Eric , Zdilla Michael J.
Published: October 2021

The discovery of solid‐phase, inexpensive transition‐metal‐based water oxidation catalysts is a central goal for renewable energy, and has led to a general consensus that a partially populated metal eg d‐electronic state is desirable, leading to favorable catalysis for certain elements in specific oxidation states. In manganese systems, the key species is manganese(III), whose high‐spin d4 electronic configuration places an unpaired electron in the eg orbital, which is postulated to contribute to electronic and structural features that support catalysis. Based on density functional theory calculations, it is predicted that electron transfer would be facilitated by a catalyst with alternating low‐ and high‐MnIII‐content sheets, which positions neighboring band edges in closer energetic proximity. The preparation of such catalysts is demonstrated for the first time and it is shown that the catalytic activity is maximized in these systems over more uniform, but more MnIII‐rich systems. The best catalyst possesses alternating high‐and low‐average oxidation state sheets with interlayer Cs+ ions, and has an overpotential of 450 mV at 10 mA, which represents an improvement of 250 mV over the best unmodified synthetic potassium birnessites. Using scanning tunneling spectroscopy, bandgap modulations consistent with the theoretically predicted band edge shifts are detected.
Iron(II)‐catalyzed Oxidative Coupling of Vicinal Diols and 2‐Amino‐1,4‐naphthoquinone for the Synthesis of Pyrrolonaphthoquinones and Furanonaphthoquinones
Authors: Maity Sujit , Gupta Sandip Kumar , Panda Niranjan
Published: October 2021

Direct oxidative coupling of vicinal diols with 2‐aminonaphthoquinones has been studied for the selective synthesis of benzo[f]indole‐4,9‐diones at a moderate temperature. In the presence of an environmentally benign iron catalyst, the vicinal diols were oxidized to α‐hydroxy carbonyl compounds. Subsequently, 2‐amino naphthoquinone reacted with the resultant α‐hydroxy carbonyl compound through tandem N−C and C−C bond formation to afford a vast range of pyrrolonaphthoquinones in remarkable yield. Interestingly, when the 1,2‐propanediol was used, the secondary alcohol group was oxidized preferably by resulting in the 2‐methyl pyrrolonaphthoquinones as the major regioisomer. The synthetic utility of the current strategy was extended for one‐step delivery of natural products, such as 3‐methyl‐1H‐benzo[f]indole‐4,9‐dione (a secondary metabolite isolated from Goniothalamus tapis Miq. with anti‐PAF activity), antibiotic utahmycin B (3‐methyl‐1H‐benzo[f]indole‐4,9‐dione), cytotoxic avicequinone B and anti‐viral FNQ3 (2‐methyl‐naphtho[2,3‐b]furan‐4,9‐dione).
Adiabatic Pumping in a Generalized Aubry–André Model Family with Mobility Edges
Authors: Xing Yan , Qi Lu , Zhao Xuedong , Lü Zhe , Liu Shutian , Zhang Shou , Wang Hong‐Fu
Published: October 2021

The adiabatic pumping between left and right end modes in a generalized Aubry–André model family with mobility edges by resorting to two end–bulk–end channels is investigated. It is shown that the system can be in an intermediate regime mixed with localized and extended phases as the mobility edge is introduced. One of the channels can remain intact even when the parameter determining the localization–delocalization transition exceeds the threshold of the paradigmatic Aubry–André model, leading to that the parametric condition for successful pumping is relaxed. Moreover, it is found that widening the region of the hybrid phase can further enhance the effect of the mobility edge. The pumping result is also quantified based on the fidelity and check the corresponding pumping process to validate these observations. Furthermore, another channel to realize a flexible adiabatic pumping among four types of generalized end modes is engineered. This work enables the potential application of mobility edges in strong–quasidisorder–immune quantum state transfer.
Segregated polylactide/poly(butylene adipate‐co‐terephthalate)/MWCNTsnanocomposites with excellent electrical conductivity and electromagnetic interference shielding
Authors: Liu Yufan , He Hezhi , He Guoshan , Zhao Jianxiong , Yang Yike , Tian Guidong
Published: October 2021

As plastic pollution becomes more serious, we need to find out eco‐friendly materials to alleviate the pollution. Polylactide (PLA) and poly (butylene adipate‐co‐terephthalate) (PBAT) will be one of the most attractive materials to replace those undegradable materials. However, few studies research the segregated conductive PLA/PBAT/MWCNTs nanocomposites. Herein, PLA/PBAT/MWCNTs nanocomposites with the segregated structure were successfully fabricated firstly. The MWCNTs are selectively dispersed in the continuous PBAT phase. The nanocomposite with segregated structure owns excellent electric conductivity. When the content of MWCNTs is 0.41 vol%, the electrical conductivity of composites with segregated structure is 9.43 × 10−4 S/m, which is about 5 orders higher than the nanocomposites without the segregated structure (1.75 × 10−10 S/m). The segregated nanocomposite with 2 wt% (1.18 vol%) MWCNTs owns excellent electromagnetic interference (EMI) of 24 dB, while the ordinary structure of composite is only 17 dB.
Detection of four foodborne pathogens based on magnetic separation multiplex PCR and capillary electrophoresis
Authors: He Shiyu , Huang Yanzhi , Ma Yingwei , Yu Haoyan , Pang Bo , Liu Xingxing , Yin Caihong , Wang Xiaomu , Wei Yuan , Tian Yuling , Zhao Chao , Xu Kun , Wang Juan , Lv Chunping , Song Xiuling , Jin Minghua
Published: October 2021

Foodborne pathogen contamination is a major safety issue for many foods and is causing concern worldwide. In this study, a detection system based on magnetic separation, multiplex PCR (MPCR) and capillary electrophoresis (CE) technologies was developed for the simultaneous detection of four foodborne pathogens. Magnetic separation technology is used to rapidly capture pathogenic bacteria in food samples, and then a combination of MPCR and CE can be used to greatly increase detection sensitivity. The detection limit for bacterial DNA reached 10−5–10−7 ng μL−1 and in the analysis of mocked food samples, the assay showed good sensitivity for bacterial detection ranging from 101 to 105 CFU mL−1 with excellent specificity. Compared to similar detection methodologies, this technique avoids the need for time‐consuming enrichment cultures, is more sensitive, and can be used to assay simultaneously four foodborne pathogens.
Circular economy and innovation: A look from the perspective of organizational capabilities
Authors: Sehnem Simone , de Queiroz Adriane A. Farias S. L. , Pereira Susana Carla Farias , dos Santos Correia Gabriel , Kuzma Edson
Published: October 2021

Studies of circular economy and innovation have received increasing attention in academic literature in the last quadrennium. They fill a managerial gap on how to operationalise the transition from the linear model to the circular. They show practices, tools and mechanisms that allow creation of business models based on circularity premises. In this article, we seek to identify the intellectual contours of this emerging field, conducting a review of the basic conceptual framework, with an analysis of articles published on the topic of circular economy and innovation. In summary, a systematic literature review was developed, whose final bibliographic portfolio consisted of 94 analysed papers. The results of the study show that eco‐innovation and innovation in business models are highlighted in this field. They are operationalised, mainly, by activating dynamic, relational and absorptive capabilities. The most important innovation practices in this context are waste management, eco‐design business models, product leasing and collaborative commerce. The main contribution of this study is to pave the way for new conceptual developments in organisational capabilities to make transition sustainable and serve as a support arsenal for the maturation of circular economy studies supported by the theory of innovation and also to link management practices to operational processes in the business and production environment favouring the transition to a circular business model. It generates insights for the scientific progression of studies and shows propositions that can be validated in future quantitative studies.
A construction and comprehensive analysis of ceRNA networks and infiltrating immune cells in papillary renal cell carcinoma
Authors: Fan Yaqi , Dai Fangfang , Yuan Mengqin , Wang Feiyan , Wu Nanhui , Xu Mingyuan , Bai Yun , Liu Yeqiang
Published: October 2021

Background

As the second most common malignancy in adults, papillary renal cell carcinoma (PRCC) has shown an increasing trend in both incidence and mortality. Effective treatment for advanced metastatic PRCC is still lacking. In this study, we aimed to establish competitive endogenous RNA (ceRNA) networks related to PRCC tumorigenesis, and analyze the specific role of differentially expressed ceRNA components and infiltrating immune cells in tumorigenesis.

Methods

CeRNA networks were established to identify the key ceRNAs related to PRCC tumorigenesis based on the 318 samples from The Cancer Genome Atlas database (TCGA), including 285 PRCC and 33 normal control samples. The R package, “CIBERSORT,” was used to evaluate the infiltration of 22 types of immune cells. Then we identified the significant ceRNAs and immune cells, based on which two nomograms were obtained for predicting the prognosis in PRCC patients. Finally, we investigated the co‐expression of PRCC‐specific immune cells and core ceRNAs via Pearson correlation test.

Results

COL1A1, H19, ITPKB, LDLR, TCF4, and WNK3 were identified as hub genes in ceRNA networks. Four prognostic‐related tumor‐infiltrating immune cells, including T cells CD4 memory resting, Macrophages M1, and Macrophages M2 were revealed. Pearson correlation test indicated that Macrophage M1 was negatively related with COL1A1 (p < 0.01) and LDLR (p < 0.01), while Macrophage M2 was positively related with COL1A1 (p < 0.01), TCF4 (p < 0.01), and H19 (p = 0.032). Two nomograms were conducted with favorable accuracies (area under curve of 1‐year survival: 0.935 and 0.877; 3‐year survival: 0.849 and 0.841; and 5‐year survival: 0.818 and 0.775, respectively).

Conclusion

The study constructed two nomograms suited for PRCC prognosis predicting. Moreover, we concluded that H19‐miR‐29c‐3p‐COL1A1 axis might promote the polarization of M2 macrophages and inhibit M1 macrophage activation through Wnt signaling pathway, collaborating to promote PRCC tumorigenesis and lead to poor overall survival of PRCC patients.
Ionic Liquid Modified Electrochemical Capacitor with Long‐Term Performance
Authors: Znaniecki Szymon , Szwabińska Katarzyna , Wojciechowski Jarosław , Skrzypczak Andrzej , Lota Grzegorz
Published: October 2021

Ionic liquids are used, for example, as corrosion inhibitors for metals, steel, and metal alloys. The method of preventing corrosion through the whole group of these kinds of compounds, called inhibitors, is to use them as additives to aggressive environments, including aqueous electrolytes. In this article, we present the inhibitive effect of imidazolium ionic liquids with 2,5‐dihydroxybenzenesulfonate anion on the corrosion of 316L stainless steel in neutral medium. In addition, we demonstrate that when the ionic liquid is used as an additive to the electrolyte solution (1 M Na2SO4) of a symmetric carbon/carbon electrochemical capacitor with 316L stainless‐steel current collectors, the capacitor lifetime is significantly extended. The ionic‐liquid additive inhibits corrosion of the current collector surface and, in effect, prevents activated carbon porous space from being blocked by corrosion products.
Recovery of Al, Co, Cu, Fe, Mn, and Ni from spent LIBs after Li selective separation by COOL‐Process – Part 2: Solvent Extraction from Sulphate Leaching Solution
Authors: Pavón Sandra , Kaiser Doreen , Bertau Martin
Published: October 2021

The market for lithium‐ion batteries (LIB) is experiencing substantial growth, what is owed to electromobility and the growing demand for cordless devices. Securing the raw material base for LIB is mandatory to achieve the objectives of EU commission's Green Deal. This implies not only sufficient access to lithium but also the accompanying metals, above all Co, Ni, Mn. After preceding recovery of Li2CO3 by the COOL‐Process and subsequent acid digestion of the Li‐free black mass, value metals, such as Co, Cu, Ni, and Mn were recovered by counter‐current solvent extraction. Fe (98.5 ± 0.65 %), Co/Mn (99.8 ± 0.78 %; 99.9 ± 1.11 %), Al (99.7 ± 1.07 %) and Cu/Ni (97.8 ± 1.46 %; 98.6 ± 1.32 %) were selectively extracted with high discriminatory power using cationic exchangers and solvating extractants such as D2EHPA and TBP, respectively. This way, a complete, holistic recycling process for LIB is at hand that allows for recovering housing material, lithium and the accompanying metals almost quantitatively.
Clinical value of pulmonary congestion detection by lung ultrasound in patients with chronic heart failure
Authors: Li Na , Zhu Yunlong , Zeng Jianping
Published: October 2021

Chronic heart failure is one of the common causes of hospitalization and death. Pulmonary congestion is the common disease feature of patients with chronic heart failure, which could be correctly diagnosed by lung ultrasound. Efficacy of lung ultrasound‐guided pulmonary congestion management for patients with acute heart failure is well documented, however, more evidence is needed to establish the clinical value of pulmonary congestion detection by lung ultrasound examination in patients with chronic heart failure. This review summarized current evidence related to the use and clinical value of pulmonary congestion assessment by lung ultrasound in patients with chronic heart failure, aiming to provide new suggestions on promoting the widespread use of lung ultrasound in patients with chronic heart failure to improve the quality of life and outcome of patients with chronic heart failure.
Amino Acid Based Antimicrobial Agents – Synthesis and Properties
Authors: Nowak Michał G. , Skwarecki Andrzej S. , Milewska Maria J.
Published: October 2021

Structures of several dozen of known antibacterial, antifungal or antiprotozoal agents are based on the amino acid scaffold. In most of them, the amino acid skeleton is of a crucial importance for their antimicrobial activity, since very often they are structural analogs of amino acid intermediates of different microbial biosynthetic pathways. Particularly, some aminophosphonate or aminoboronate analogs of protein amino acids are effective enzyme inhibitors, as structural mimics of tetrahedral transition state intermediates. Synthesis of amino acid antimicrobials is a particular challenge, especially in terms of the need for enantioselective methods, including the asymmetric synthesis. All these issues are addressed in this review, summing up the current state‐of‐the‐art and presenting perspectives fur further progress.
Cytomorphologic features of intraductal salivary gland carcinoma: A multi‐institutional study of 13 FNA cases with histologic, molecular, and clinical correlations
Authors: Viswanathan Kartik , Sadow Peter M. , Maleki Zahra , Nishino Michiya , Baloch Zubair W. , Abbott Todd E. , Rao Rema , Faquin William C.
Published: October 2021

Background

Intraductal carcinoma of the salivary gland (IDC) is a rare cancer with potential actionable targets, including RET fusions. Histologic and molecular features of IDC were recently reported, but cytomorphologic data are limited. In the largest multi‐institutional fine‐needle aspiration (FNA) series, the authors describe the cytomorphologic features of 13 IDC cases with available clinical, radiologic, histopathologic, and molecular data.

Methods

The cases included 13 FNAs for 9 low‐grade (LG) IDCs and 4 high‐grade (HG) IDCs with corresponding histopathology and available molecular, imaging, and clinical data. Smears and liquid‐based preparations available for 12 FNAs were semiquantitatively scored for key cytomorphologic findings and correlated with the corresponding resection.

Results

LG IDC FNAs showed a cellular, biphasic population of large, atypical ductal cells with mildly pleomorphic nuclei in a clean background and a minor population of small, uniform myoepithelial cells. In contrast, all HG IDC FNAs showed predominantly ductal cells with marked nuclear pleomorphism, coarse chromatin, and necrosis. With the Milan system, most LG and HG IDC FNAs were classified as either salivary gland neoplasms of uncertain malignant potential (54%) or malignant (31%). Immunohistochemistry showed ductal epithelial reactivity with mammaglobin, androgen receptor, and S100, whereas myoepithelial cells were positive for p63 and/or calponin. Among cases with next‐generation sequencing, 4 LG IDCs showed NCOA4‐RET gene fusions, whereas an HG IDC showed HRAS and PIK3CA mutations.

Conclusions

The cytomorphology of IDC overlaps with other benign and malignant salivary gland neoplasms. Immunohistochemistry limits the differential diagnosis, but definitive classification requires molecular analysis. A diagnosis of IDC has potential implications for patient management.
Non‐suicidal self‐injury in US military veterans: Results from the National Health and Resilience in Veterans Study
Authors: Kachadourian Lorig K. , Nichter Brandon , Herzog Sarah , Norman Sonya B. , Sullivan Tami , Pietrzak Robert H.
Published: October 2021

Background

To evaluate the prevalence of lifetime non‐suicidal self‐injury (NSSI) among US military veterans and identify sociodemographic, military, psychiatric and clinical correlates associated with NSSI.

Methods

Data were analysed from the 2019–2020 National Health and Resilience in Veterans Study, a contemporary, nationally representative survey of 4069 US veterans. Outcomes measured included lifetime history of NSSI, trauma history, lifetime and current DSM‐V mental disorders and lifetime and recent suicidal behaviours.

Results

The overall prevalence of lifetime NSSI was 4.2% (95% confidence interval [3.6%, 4.9%]). Multivariable analyses revealed that veterans who endorsed lifetime NSSI were more likely to be younger, female, non‐Caucasian, unmarried or unpartnered, and to have a lower annual household income. Veterans who endorsed lifetime NSSI reported more adverse childhood experiences and lifetime traumas and were more likely to have experienced military sexual trauma. They also were more likely to screen positive for lifetime posttraumatic stress disorder, major depressive disorder (MDD) and substance use disorders and to have attempted suicide. Finally, lifetime NSSI was associated with current MDD, generalized anxiety disorder, and substance use disorders, as well as past‐year suicidal ideation.

Conclusion

Results of this study provide the first‐known data on the epidemiology of NSSI in US military veterans. They suggest that certain correlates can help identify veterans who may be at greater risk for engaging in NSSI, as well as the potential prognostic utility of lifetime NSSI in predicting current psychiatric problems and suicide risk in this population.
Nutritional status during hospitalization is associated with the long‐term prognosis of patients with heart failure
Authors: Takada Takuma , Jujo Kentaro , Inagaki Keiko , Abe Takuro , Kishihara Makoto , Shirotani Shota , Endo Nana , Watanabe Shonosuke , Suzuki Kazuhito , Minami Yuichiro , Hagiwara Nobuhisa
Published: October 2021

Aims

The CONtrolling NUTritional status (CONUT) score represents the nutritional status of patients with heart failure (HF). Although high CONUT scores on admission are associated with increased risks of cardiovascular (CV) events in patients with HF, the impact of CONUT changes during hospitalization on their long‐term prognosis is unclear. This study aimed to investigate the impact of CONUT score changes on the clinical outcomes of patients with HF after discharge.

Methods and results

This observational study included 1705 patients hospitalized with HF who were discharged alive. The patients were categorized depending on their CONUT scores at admission and discharge into persistently high, high at admission and normal at discharge, normal at admission and high at discharge, and persistently normal CONUT groups. The primary endpoint was a composite of CV death and readmission for HF after discharge. The primary endpoint occurred in 652 patients (38%) during the median 525 day follow‐up period. Patients with persistently high CONUT scores had the highest composite endpoint rate (log‐rank trend test: P < 0.001). After adjusting for covariates, the hazard ratio for the composite outcome was significantly lower for the patients with high CONUT scores at admission and normal CONUT scores at discharge than that for those with persistently high CONUT scores (hazard ratio: 0.69; 95% confidence interval: 0.49–0.98).

Conclusions

Nutritional status changes in patients with HF that occurred during hospitalization were associated with CV events after discharge. Improving the nutritional status of patients may improve their clinical outcomes.
β‐Keto Amides: A Jack‐of‐All‐Trades Building Block in Organic Chemistry
Authors: Li Wanfang , Zheng Yan , Qu Erdong , Bai Jin , Deng Qinyue
Published: October 2021

β‐Keto amides are a versatile class of compounds that find wide applications in organic chemistry owing to the juxtaposition of multiple reaction sites within their molecular structures. Due to the importance of β‐keto amides in modern organic chemistry, numerous novel preparation methods, synthetic applications and unprecedented reactivities have been recorded over the past decade. Taking advantage of transition‐metal‐catalysis and organocatalysis, β‐keto amides have emerged into a jack‐of‐all‐trades building block for many stereoselective or tandemized multicomponent reactions. But so far, no reviews have been documented on these recent achievements with β‐keto amides. Our Review aims to provide a thorough summary regarding: (a) the synthesis of β‐keto amides, (b) the reactivities of β‐keto amides, (c) the synthetic applications of β‐keto amides in various important heterocyclic compounds, and (d) the coordination of β‐keto amides with main group elements and transition metals and the relevant applications.
Twin‐model framework development for a comprehensive battery lifetime prediction validated with a realistic driving profile
Authors: Hosen Md Sazzad , Kalogiannis Theodoros , Youssef Rekabra , Karimi Danial , Behi Hamidreza , Jin Lu , Van Mierlo Joeri , Berecibar Maitane
Published: October 2021

Lithium‐ion technologies have become the most attractive and selected choice for battery electric vehicles. However, the understanding of battery aging is still a complex and nonlinear experience which is critical to the modeling methodologies. In this work, a comprehensive lifetime modeling twin framework following semi‐empirical methodology has been developed to predict the crucial degradation outputs accurately in terms of capacity fade and resistance increase. The constructed model considers all the relevant aging influential factors for commercial nickel manganese cobalt (NMC) Li‐ion cells based on long‐term laboratory‐level investigation and combines both the cycle life and the calendar life aspects. To demonstrate robustness, the model is validated with a real‐life worldwide harmonized light‐duty test cycle (WLTC). The model can precisely predict the capacity fade and the internal resistance growth with a root‐mean‐squared error (RMSE) of 1.31% and 0.56%, respectively. The developed model can be used as an advanced online tool forecasting the lifetime based on dynamic profiles.
Alternative seismische Quellen für die Vorauserkundung im konventionellen Tunnelbau
Authors: Hartl Irene , Schlögel Ingrid , Behm Michael , Wenighofer Robert , Galler Robert
Published: October 2021

For seismic ahead‐of‐the‐face prediction in tunnelling, sources with known properties are usually used, which, however, are not compatible with NATM. In order to integrate geophysical exploration into conventional tunnelling, the feasibility of construction machinery for generating seismic source signals was investigated. Passive monitoring during conventional tunnelling was used to analyse the seismic signals. Different radiation characteristics of drilling, blasting and bouldering could be identified and their characteristics regarding range and spectrum of the signal could be determined. In subsequent system tests, various machines used in NATM tunnelling were examined for their suitability as sources. The sensor positioning for source signal pickup was evaluated by stroke tests and during ongoing tunnelling operations. For the registration of the waves in the rock mass, different receivers with different geometries were used to characterize the wave field emitted to the front or side of the sources. In addition, the necessary processing steps were determined in order to make these signals usable for an ahead‐of‐the‐face exploration. The results and data form a basis for further development into a practical technical solution for conventional tunnel construction.
Der TSV im Spannungsfeld von Baugrundrisiko und Sphärentrennung
Authors: Purrer Walter
Published: October 2021

The institution of a neutral Tunnelling Expert (TE) has proven to be of benefit to Austrian Tunnelling Projects. However, misdevelopments have been observed during recent years, which lead to setbacks and obstructions against utilizing its full potential. On the basis of practical experiences, the reasons and backgrounds are explained and options for improved collaboration of the participants by targeted involvement of the TE are shown. These considerations are not restricted to structural topics. They also take into account the mechanism of the social system of manpower cooperating in construction projects.
Einsatz kombinierter Bohrverfahren zur Vorauserkundung mit digitalem Bohrdatenmanagement
Authors: Kratz Thorsten , Vogel Guido , Ouschan Michael
Published: October 2021

The purpose of exploration drillings in tunnelling operations is to investigate rock structure, geological composition of the rock, especially with regard to fault zones, and the identification and characterisation of water‐bearing zones. When determining the quality of exploration, the economic parameters must be taken into account. The application of combined exploration drilling methods allows the successful drilling of exploration drillings even in complex geotechnical and hydrogeological rock conditions. The concept provides the flexibility to switch between drilling systems and to realise probe measures tailored to the specific geology quickly and according to economic requirements. For successful exploration projects, documents and findings from past projects are used in the planning phase. The use of digital drilling data management offers enormous potential for optimising data evaluation. The determination of machine, equipment and the preparation of a drilling plan can thus be prepared much more specifically for the upcoming exploration. During execution, direct conclusions can be reached regarding e.g. drillability or drilling tool condition on the basis of the process‐oriented process analysis.
„Fliegendes” Andrehen mit einer Gripper‐TBM in Flach‐ und Steilstrecke
Authors: Türtscher Matthias , Mark Simon , Leitner Wolfgang , Innerhofer Guntram
Published: October 2021

Contractor G. Hinteregger & Söhne Baugesellschaft mbH submitted an alternative proposal for the ”Rodundwerk I, new headrace and distribution pipe system“ project commissioned by Illwerke vkw AG which uses a new launch structure for an open gripper TBM. An Austrian utility model has been registered for this new development. This paper describes the process.