bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Thyroid Dysfunction on Complete Blood Count
Authors: Ganbaatar Bolormaa , Damdindorj Davaasuren , Tsogbadrakh Punsaldulam , Rentsentavkhai Anujin , Khuder Maralmaa , Bavuu Oyunbileg
Published: October 2023

Background: Thyroid hormones play a crucial role in metabolism and the proliferation of blood cells. Therefore, thyroid hormones have a direct effect on blood parameters by stimulating erythrocyte precursors and indirect effect by enhancing erythropoietin production. Additionally, it affects red blood cells include mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution width. In this study, we evaluated difference of complete blood count result between the healthy control, Hashimoto thyroiditis and Graves’ disease study groups. Methods and results: This is a cross-sectional study which included 158 subjects (male 9, female 149), categorized into three groups: control, hypothyroidism (patients with Hashimoto’s thyroiditis), and hyperthyroidism (patient with Graves’ disease). The analyses showed a significant difference the between the groups in term of mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red cell distribution width and monocyte (p values < 0.05). Conclusion: The functional abnormalities of the thyroid gland significantly impact blood cells, and the complete blood cell count results play a critical role in the diagnosis of the condition.
Perineal cutaneous basal cell carcinomas in patients with familial seronegative celiac disease: Report of three cases
Authors: Lambert W. Clark
Published: October 2023

Introduction: Celiac disease (CD) is an autoimmune enteropathy due to hypersensitivity to consumed gluten. Patients can present with gastrointestinal and systemic symptoms. CD often runs in families. Studies have reported multiple subtypes of CD including at least one seronegative variant. The cutaneous manifestations of CD remain to be delineated; some cases of seropositive CD are associated with dermatitis herpetiformis. We report. Cases: In this study, three patients with a longstanding history of personal and/or familial seronegative CD presented withwho developed basal cell carcinoma (BCC) of the perineum. We hope to inform clinical physicians about the possible relationship between CD and cutaneous malignancies. DiscussionResults: We report three adult patients with a diagnosed or suspected personal history of seronegative CD and a family history of CD, who presented with BCC of the perineum. Discussion: The mechanism by which CD causes BCC remains to be defined. Physicians should consider testing evaluating patients with skin cancer located in the perineum for CD.
Serum Albumin as Independent Predictor In Determining The Outcome Of Traumatic Brain Injury
Authors: Hashim Mohd , Awang Mohamed , Ramanathan Alarmelu , Wahab Mohd , Mohd Nor Mohd , Aidid Edre
Published: October 2023

Context: Serum albumin is the major protein of the human plasma, accounting for about 60% of the total plasma protein. Serum albumin levels tend to decline in the plasma due to injury or infection independent of nutritional status. Serum albumin consumption increases in a state of stress. Reduction in serum albumin occurs with intracranial haemorrhages. In a patient with severe head injury, there is a significant decline in serum albumin leading to hypoalbuminemia. Serum albumin can be used as an outcome marker in various critical illnesses, including traumatic brain injury. Aim: To determine that serum albumin is an independent predictor affecting the outcome of patients with severe traumatic brain injury over a 6-month duration Settings and design: This was conducted as prospective cohort study in two neurosurgical centres in the East Coast of Malaysia from June 2020 to June 2021 Subjects and methods: A total of fifty-five patients were admitted to our emergency intensive care, or high dependency unit with varying degrees of severe head injuries. Forty patients fulfilled the inclusion criteria of our study and were recruited for data collection and further analysis. Their serum albumin levels were drawn, analysed, and recorded. Statistical analysis used: Descriptive, univariate and multivariate analyses using Multiple Logistic Regression model were done using SPSS version 26.0. Results: Average age for patients in this study was 42 years old. 87.5% of patients involved in this study were male, while the remaining 12.5% were female. The ethnicity of the majority of patients were Malays (77.5%) and the other ethnicities involved were Chinese, Indians and Bangladeshi, with a total of 22.5%. Multiple intracranial injuries were suffered by 57.5% of our study population, Subdural Hemorrhage, Extradural Hemorrhage, Contusional bleed, and Diffuse Axonal Injury were seen respectively in 20%, 10% 7.5% and 5% of the study population. At six months, the unfavourable outcome for serial serum albumin in patients with severe head injury patients was 62.5%, while the favourable outcome was 37.5%. Serum albumin of 30 g/L or less than 30g/L at day 1,3 and 5 post-trauma was noted to have unfavourable outcomes compared to serum albumin level of more than 30g/L. Conclusion: Serum albumin is an independent predictor of outcome in severe TBI patients. However, larger prospective studies are required to verify these findings.
COVID-19 Effects on Companies Owned by Disabled Entrepreneurs
Authors: Mishrif Ashraf , Al-qamashoui Aziza , Al-Quraini Noof , Al-Fahdi Safa
Published: October 2023

The COVID-19 pandemic has caused considerable operational and financial challenges to companies, particularly those owned or managed by disabled entrepreneurs. While assessing the impact of the pandemic on the performance of the surveyed companies, this study attempts to explain how disabled entrepreneurs reacted to the effects of the pandemic and their success and shortfalls in overcoming the business and commercial challenges during the pandemic. Focus group discussions were used to collect primary data, with the aim of identifying and exploring different variables that influence the activities of disabled entrepreneurs and affect their business. The content analysis technique was also used to analyze the primary data to determine the status and conditions of companies owned by disabled entrepreneurs and to provide SWOT analysis of these companies. The results revealed that companies owned by disabled entrepreneurs demonstrated resilience and adaptability in surviving the pandemic, despite shortcomings such as falling trade operations, fewer customers, and higher operational expenses. The findings also identified some successful business models, where disabled entrepreneurs were able to adapt to the changing business environment by implementing digital technologies, accepting creative solutions, and changing business strategies. Our findings make original contribution to the field by identifying the serious challenges that encounter disabled entrepreneurs and stressing the urgency of developing specific policies to provide technical and financial support to this group at the time of crises.
Long COVID, Non-COVID19 Excess Deaths, and Post-Pandemic Cardiovascular Disease Risks: Mechanistic Links and Intervention Opportunities Mechanistic Links and Intervention Opportunities
Authors: Chung Jinhyuk
Published: October 2023

Persistent non-COVID19 excess mortality is a major post-pandemic health crisis without clear explanation. In current review, the hypothesis of Long COVID’s causal link to the non-COVID19 excess mortality was studied by applying time-lag correlation analysis between the excess death with COVID19 and the excess death without COVID19 in Australia between Jan 2020 and Mar 2023, which revealed a remarkable correlation that coincided with the disease severity of the corresponding variants including Delta, Omicron BA.1-BA.3, and Omicron BA.4-BA.5 waves. Based on the correlating epidemiological findings, known immunity-mediated pathologies of Long COVID such as endothelial damage, thrombosis, and bleeding were explored in contemplating acute coronary syndrome as a precipitating mechanism of the non-COVID19 excess death. The identified mechanistic linkage of non-COVID19 excess mortality to Long COVID paves ways for its countermeasures. Additional measures of using nasal hygiene products to curb the airborne infection risks, reserved physical exercise in the months after the recovery of COVID19, closer management of cardiovascular diseases (CVD) and diabetic risk factors, and root-level Long COVID treatments tailored to treating the dysfunctional immunity around macrophages and neutrophils are proposed to reduce the non-COVID19 excess deaths.
Smoking Cessation Management for Lung Cancer Smokers: An Essential Component of Treatment
Authors: Perriot Jean , Underner Michel , Peiffer Gérard
Published: October 2023

In 2020 lung cancer has been the leading cause of cancer death, with an estimated 1.8 million deaths; in other words of 18% of cancer deaths. Tobacco smoking is cause of 90% of lung cancers. Despite advances in lung cancer treatment, tobacco control is the most effective measure for curbing the lung cancer epidemic. Smoking cessation, at all stages of the cancer process, is associated with benefits in terms of cure, increased life expectancy and quality of life for patients, reduced medical and surgical complications, as well as it reduces risks of recurrence or of a second primary cancer. Smoking cessation medications combined with psychological support facilitate to quit smoking. Smoking cessation management is an essential component of lung cancer treatment. Researches into the best modalities to manage smoking cessation in lung cancer patients must be conducted. Nevertheless, healthcare professionals involved in the care of cancer patients must be trained to provide personalized assistance to help smokers stopping smoking.
Effects of Vascular Risk Factors on the Association of Blood-Based Biomarkers with Alzheimer's Disease
Authors: SS Hoost , AM Brickman , JJ Manly , LS Honig , Y Gu , D Sanchez , D Reyes-Dumeyer , RA Lantigua , MS Kang , JL Dage , R Mayeux
Published: October 2023

Background: Comorbidities may influence the levels of blood-based biomarkers for Alzheimer’s disease (AD). We investigated whether differences in risk factors or comorbid conditions might explain the discordance between clinical diagnosis and biomarker classifications in a multi-ethnic cohort of elderly individuals. Aims: To evaluate the relationship of medical conditions and other characteristics, including body mass index (BMI), vascular risk factors, and head injury, with cognitive impairment and blood-based biomarkers of AD, phosphorylated tau (P-tau 181, P-tau 217), in a multi-ethnic cohort. Methods: Three-hundred individuals, aged 65 and older, were selected from a prospective community-based cohort for equal representation among three racial/ethnic groups: non-Hispanic White, Hispanic/Latino and African American/Black. Participants were classified into four groups based on absence (Asym) or presence (Sym) of cognitive impairment and low (NEG) or high (POS) P-tau 217 or P-tau 181 levels, determined previously in the same cohort: (Asym/NEG, Asym/POS, Sym/NEG, Sym/POS). We examined differences in individual characteristics across the four groups. We performed post-hoc analysis examining the differences across biomarker and cognitive status. Results: P-tau 217 or P-tau 181 positive individuals had lower BMI than P-tau negative participants, regardless of symptom status. Symptomatic and asymptomatic participants did not differ in terms of BMI. BMI was not a mediator of the effect of P-tau 217 or P-tau 181 on dementia. Frequencies of other risk factors did not differ between the four groups of individuals. Conclusions: Participants with higher levels of P-tau 217 or P-tau 181 consistent with AD had lower BMI regardless of whether the individual was symptomatic. These findings suggest that weight loss may change with AD biomarker levels before onset of cognitive decline. They do not support BMI as a confounding variable. Further longitudinal studies could explore the relationship of risk factors with clinical diagnoses and biomarkers.
Testosterone Level and Risk of Diabetes: Follow-Up Study
Authors: Rezanezhad Babak , Borgquist Rasmus , Elzanaty Saad
Published: October 2023

Background: Epidemiological studies have documented an inverse relationship between testosterone levels and risk of cardiovascular disease. The present study aimed to explore the association between testosterone levels and risk of developing diabetes mellitus from 108 middle-aged men with no history of medical diseases. Methods: Data regarding the age of subjects, smoking, alcohol consumption, waist-to-hip ratio, and family history of cardiovascular disease were collected at the time of inclusion. Testosterone levels were also measured. 15 years later the medical history of the men was reviewed to record the development of medical incidents with references to diabetes mellitus. Two groups of men were identified based on testosterone levels: hypogonadal (testosterone ≤12 nmol/L) and eugonadal (testosterone >12 nmol/L). Results: In total, 10 (9.0%) out of 108 men developed diabetes during the 15-year follow-up period, of whom 6 (16%) out of 37 and 4 (6%) out of 71 were men in the hypogonadal and eugonadal cohorts respectively (p=0.08). Using Cox proportional hazards regression analysis, the adjusted risk for diabetes was significantly lower in eugonadal men compared to hypogonadal men (adjusted hazard ratio=0.236; 95% CI=0.062–0.898; P=0.03). Conclusion: Our results showed a significant increased risk of diabetes in men with low testosterone levels compared to men with normal testosterone.
Aprendamos todos a leer: Fascículo 39: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. Este fascículo los niños podrán realizar diferentes actividades para conocer los sonidos la letra X-x. Al inicio de las palabras suena /s/. A la mitad o al final de las palabras la X-x tiene dos sonidos juntos, ks. Les ayudaremos a combinarlas con las vocales y las consonantes y las consonantes M-m, P-p, N-n, L-l, S-s, F-f, T-t, B-b, D-d, C-c, QU-qu, Y-y, Ll-ll, H-h, Ch-ch, R-r, G-g, J-j, Z-z, -ñ, K-k.
Aprendamos todos a leer: Fascículo 42: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. Este fascículo los niños podrán realizar diferentes actividades para tomar el lápiz de forma segura, fortalecer el trazo, seguir la dirección del trazo, colocar el papel de forma correcta y sentarse de manera adecuada.
Aprendamos todos a leer: Fascículo 44: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. En este fascículo tomamos un respiro de las habilidades específicas para aprender a leer y escribir, para mostrarles cómo pueden apoyar a sus hijos realizando actividades de la vida cotidiana.
Aprendamos todos a leer: Fascículo 34: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. Este fascículo los niños podrán realizar diferentes actividades para romper el dígrafo Gu-gu y permitir que la u suene cuando se combina con las vocales e, i: Güe-güe y Güi-güi. Les ayudaremos a combinarlas con las vocales a, o, u y las consonantes y las consonantes M-m, P-p, N-n, L-l, S-s, F-f, T-t, B-b, D-d, C-c, QU-qu, V-v, Ll-ll, Y-y, H-h, Ch-ch, R-r, G-g.
Aprendamos todos a leer: Fascículo 28: Toda la familia lee y escribe conmigo
Authors: De Varela Ana Lorena , Martínez Álvarez Silvia
Published: October 2023

Aprendamos Todos a Leer es la iniciativa para la enseñanza de lectura y escritura inicial del BID, donde a través de materiales para el alumno, el maestro y el aula de clase, pretende brindar herramientas para apoyar el proceso de alfabetización inicial. El programa se organiza a partir de una cartelera fonológica presentando para cada fonema (sonido de letra) un personaje caracterizado por un animal. En respuesta al COVID-19, se desarrollaron fascículos para apoyar el trabajo en casa. Este fascículo contiene orientaciones para enseñar el sonido y escritura de la letra R-r, su combinación con las vocales y las consonantes M-m, P-p, N-n, L-l, S-s, F-f, T-t, B-b, D-d, C-c, QU-qu, V-v, Ll-ll, Y-y, H-h, Ch-ch.
Posición del incisivo inferior en pacientes de clase esqueletal I y II según su biotipo facial en una muestra de una clínica privada, Cali 2014 – 2020
Authors: Duque-Duque Ingrid Julieth , Perea Xamayris , Puerta German , Gutiérrez-Quiceno Bruno
Published: October 2023

Introducción: la sínfisis mentoniana es la articulación cartilaginosa medial de los huesos mandibulares, su posición se relaciona con los diferentes biotipos y puede influir en la posición del incisivo inferior. Objetivo: determinar si existen variaciones en la posición del incisivo inferior, en pacientes clase II con diferentes biotipos. Materiales y métodos: se evaluaron la totalidad de tomografías de pacientes clase I y II esquelética que asistieron entre 2014 y 2020 a una clínica privada, teniendo una muestra total de 74 pacientes, caracterizándolos por sexo y edad. Se determinó biotipo facial, Incisor Mandibular Plane Angle, distancias a la sínfisis como el ACV-ACL y altura desde el ápice. Para el análisis se utilizó I-CAT Visión Q, para las medidas de las tomografías digitales y para el análisis estadístico Stata 17. Resultados: se encontró un Incisor Mandibular Plane Angle mayor en pacientes clase II en los tres biotipos; los dolicofaciales clase II mostraron menor valor en corticales ACV–ACL, los pacientes mostraron mayor proinclinación en la clase II. La posición del incisivo en pacientes clase II presenta una proinclinación significativa en braquifaciales (p = 0.04). Conclusión: se encontraron variaciones entre los tres biotipos faciales en las diversas mediciones en pacientes clase I y II, el sexo femenino evidenció diferencias significativas en las clases en las medidas del Incisor Mandibular Plane Angle y la altura de la sínfisis a nivel del ápice; estos hallazgos son relevantes en el momento de realizar un tratamiento ortodóntico ya que puede limitar el movimiento de los incisivos inferiores.
Desigualdades sociales urbano-rurales en la mortalidad por siniestros viales en Colombia, 1998-2019
Authors: Montenegro-Martínez Gino , Arias-Castro Carlos Esteban , Cardona-Arango Doris
Published: October 2023

Introducción: anualmente se pierden 1,35 millones de vidas por causa de siniestros viales; su ocurrencia se ha relacionado, además de factores comportamentales, con desigualdades sociales. Objetivo: analizar las desigualdades sociales urbano-rurales en la mortalidad por siniestros viales en Colombia para el periodo 1998-2019. Materiales y métodos: estudio ecológico a partir del análisis de las tasas de mortalidad ajustadas por edad y sexo de los grupos poblacionales urbanos y rurales estratificados por sexo. Se hicieron análisis con regresión de Jointpoint y se calcularon medidas de desigualdad simple absoluta y relativa. Resultados: se registraron 139 323 muertes por siniestros viales; en Colombia, la tasa de mortalidad por esta causa se ha venido reduciendo. En contraste con las áreas rurales, en las áreas urbanas esta reducción es más significativa. Existen desigualdades en la mortalidad entre las áreas urbanas y rurales que han venido estrechándose. No obstante, en el caso de hombres y mujeres ha venido incrementándose. Discusión: la reducción de la tasa de mortalidad por siniestros viales sugiere que las intervenciones en seguridad vial han sido efectivas. La mayor mortalidad en hombres puede explicarse a partir de factores comportamentales. Las desigualdades urbano-rurales pueden estar relacionadas con las dinámicas de desarrollo. Conclusiones: se registra una reducción en la tasa de mortalidad por siniestros viales, la cual es más significativa en áreas urbanas. Existen desigualdades urbano-rurales en la mortalidad por esta causa. Las políticas de seguridad vial deben partir de un enfoque integrador vinculado con otras agendas políticas.
A Review of the Role of Indoor Fungi in Sick Building Syndrome
Authors: Sarvtin Mehdi Taheri
Published: October 2023

Sick building syndrome (SBS) is a group of non-specific symptoms associated with the built environment, including mucosal symptoms in the eyes, nose, throat, and skin, and general symptoms such as headache and fatigue. Currently, more attention has been paid to the impact of buildings on the health and well-being of occupants, so SBS has become a global concern. Indoor microbial agents such as fungi are important in causing this syndrome. Fungi are eukaryotic microorganisms that occur in indoor air. Among the fungi, Cladosporium, Aspergillus, Stachybotrys, and Penicillium have a significant role in causing SBS. Fungi can contribute to this syndrome in different ways. Thus, this review article attempts to investigate the role of fungi and how to intervene in these microorganisms in SBS. To this end, keywords such as: "air," "indoor," "fungi," and "sick building syndrome" were searched. Articles published in scientific databases, such as Google Scholar, PubMed/MEDLINE, Elsevier, and Scopus were used.
Evaluation of Biological Markers in Children's Cerebrospinal Fluid with Bacterial and Viral Meningitis
Authors: Panji Mohammad , Behmard Vahideh , Raoufi Mehri Fallah , Jadidi Elnaz Sadat Mousavi Sadr , Rostami Elham , Norbakhsh Rahil , Najafi Vajiheh , Gardeshi Tohid Moradi , Safizadeh Fahimeh , Barmaki Haleh
Published: October 2023

Background and Aims: Cerebrospinal fluid (CSF) and blood biomarkers are widely evaluated as diagnostic tools to distinguish between bacterial meningitis and viral meningitis in emergency laboratory tests. So, this aimed to examine the levels of diagnostic parameters in blood and CSF to discriminate between bacterial and viral meningitis in young children referred to Khoy Hospital.
Materials and Methods: A total of 101 young children with meningitis were enrolled in this prospective study. The diagnosis of bacterial and viral meningitis was based on clinical features and laboratory findings.
Results: Of the 101 patients with meningitis, 18 (17.82%) were bacterial, and 83 (82.17%) were viral meningitis. The levels of CSF glucose and CSF/blood glucose ratio were significantly lower in the bacterial meningitis group than in the viral meningitis group (p < 0.01). In contrast, white blood cells count, CSF protein, interleukin-6, C-reactive protein, and ferritin levels were significantly higher in patients with bacterial meningitis compared to viral meningitis (p < 0.01). However, there was no difference between viral and bacterial meningitis groups concerning mean serum glucose.
Conclusion: This study suggests that decreased CSF glucose and CSF/blood glucose ratio and increased white blood cells count, CSF protein, ferritin, interleukin-6, and C-reactive protein combined with clinical symptoms can help better diagnosis of bacterial meningitis, especially in comparison with viral meningitis.
Chile: abdicación cívica e historia contra la memoria
Authors: Cassigoli Salamon Rossana
Published: October 2023

Este artículo recapitula las secuelas existenciales que asolan a familias, localidades e individuos, enmendadas o transmutadas por memoriales humanistas y vanguardistas de la experiencia dictatorial chilena de la década de 1970. Derivaciones inmateriales que han marcado, al menos, a tres generaciones, tres descendencias presentes y convivientes. Los síntomas del olvido y de una “reclamación negada” afloran bajo el peso de la cultura imperante. La presente remembranza bordea la crónica, afín al trabajo de la memoria; compendia fragmentos de interlocución crítica entre la disparidad de presencias que personifican un patrimonio disperso: el de una alteridad perdida y referida a otro tiempo cultural.
Democracia sin ciudadanos: crítica de la teoría de la transición
Authors: Ortiz Sandoval Luis
Published: October 2023

La tesis de que las formas democráticas basadas en la teoría de la “poliarquía” aseguran los procesos de transición democrática en América Latina es abstracta. La continuidad de las estructuras sociales de desigualdad en la región, demuestra que la construcción de instituciones democráticas es una mera pretensión de “jugar las reglas de juego” y de instaurar por decreto la participación de hombres y mujeres a través de “elecciones libres”, allí donde la gente no es libre ni puede elegir. Este ensayo propone que el punto a considerar en esta problemática es la construcción social de ciudadanía: proceso todavía inconcluso pero que deviene en condición de posibilidad de la democracia misma. A partir de la experiencia paraguaya, se puede constatar que las acciones colectivas no necesariamente apuntan a la creación de condiciones de acceso a la ciudadanía, sino a una cuestión aún previa: la inclusión social de las clases subalternas.
La nanociencia y la nanotecnología: una revolución en curso
Authors: Mendoza Uribe Guadalupe , Rodríguez López José Luis
Published: October 2023

La nanociencia y la nanotecnología se presentan como un área nueva de investigación en el estudio de los materiales donde convergen diversas ramas del conocimiento que permiten estudiar fenómenos inéditos que ocurren a nivel atómico y molecular. La importancia de la nanotecnología radica en que en mundo nanométrico los materiales pueden adquirir o realzar propiedades diferentes a las que tienen a escala macroscópica.Actualmente ya se encuentran algunas aplicaciones prácticas de la nanotecnología y se prevé que habrá muchas más, por lo cual es necesario evaluar el impacto que tendrían; los países desarrollados ya cuentan con programas para financiar investigaciones en este campo y, recientemente, México y otros países latinoamericanos han hecho lo propio.En este trabajo se presenta una perspectiva general de la investigación y las aplicaciones de la nanociencia y la nanotecnología, sus conceptos principales, y una revisión general de su estatus y desarrollo en México y Latinoamérica.
Water Crisis in Mexico.Reflections on Its Shortage and Management
Authors: García Sánchez Dra. María del Rocío , Reyes Añorve Dr Joaquín , Godínez Alarcón Mtra Guadalupe
Published: October 2023

Mexico is experiencing a water crisis particularly in the central and northern regions of the country due to increasing droughts. Millions of liters of water are used by the processed food industry or soft drink or beer companies, the agricultural and livestock industry among others, these are the economic activities that consume the most water. Therefore, it is important that the water crisis experienced in Mexico should not be addressed based on the lack of rain, the implementation of effective public policies for the supply of water that respond to the expectations of the population should also be considered. Another aspect that must be taken into account is that the Mexican legislation that regulates the exploitation or use of national waters, as well as their distribution, control and preservation of their quantity and quality, has to be reviewed, renewed and adapted to the current needs of the country to guarantee the human right to water. In this context and using an inductive-deductive methodology, a documentary review of national and international legislation was carried out, as well as literature related to the water crisis affecting Mexico. In short, it is important to state that the management of water resources must be based on principles of solidarity, collective access and equity, which are by definition incompatible with any commercial approach motivated by private benefit and public benefit. Definitely, the implementation of public policies that effectively combat water scarcity in Mexico must be linked to the management, protection and infrastructure for the distribution and storage of water. This includes regulating water extraction and promoting sustainable practices in all sectors of the economy.
The electromagnetic cause of gravity
Authors: Gimsa Andreas
Published: October 2023

Under the condition of the expansion of the universe and all masses with their atoms and charges in it, the electromagnetic cause of the gravitational force is determined with the help of the Lorentz force. The gravitational force, which could be founded here electromagnetically, is indentical with the mechanical gravitational force of Newton, which is cofirmed experimentally many times and is correct, but still unfounded.
Contribution to the non-destructive evaluation of bituminous mixes by electrical measurements
Authors: Meymouna Messaoud , Bachir Glaoui , Othmane Abdelkhalek , Rabehi Rachid
Published: October 2023

The incorporation of additives into bituminous mixes is a very important technique for improving the mechanical and electrical properties of the pavement body. The purpose of this work is to present and interpret the different results of the tests carried out in the laboratory; such as FENIX direct tensile test and electrical resistivity test. In this work, we will present comparative studies between the mechanical and electrical characteristics of bituminous mixes based on conductive additives (steel fibers and graphite powder). This comparison makes it possible to classify these resulting materials as materials that have the ability to respond to different multifunctional applications.
Disengagement from Moral Disengagement: A Review of Individual Differences and Interventions Programs
Authors: YALÇIN Esra , AKTAŞ Büşra
Published: October 2023

It is an intriguing question of how people can reduce stress in which situations where internal moral standards are violated. Addressing this question, moral disengagement theory has been proposed to explain different cognitive mechanisms which ease people into engaging or witnessing moral transgressions. Several findings showed that moral disengagement tendencies might be explained by individual differences as well as contextual factors. Beyond showing the correlations between moral disengagement processes and individual differences and contextual factors, it is also valuable to investigate if there is an effective way to intervene in moral disengagement. This review article addresses the previously shown evidence regarding individual differences, contextual factors, and interventions, which in turn aim to enrich our understanding of the underlying psychological mechanisms to reduce unethical behaviors. Taken together, Honesty-Modesty, Agreeableness, Conscientiousness, Psychopathy, and Machiavellianism were found to be individual differences associated with moral disengagement. Additionally, less research yielded that attachment styles, political attitudes, moral identity, and moral emotions might be important to experience moral disengagement. Although several studies showed that individual differences are related to being more prone to moral disengagement, these studies had rarely been considered in intervention programs aiming to reduce immoral behaviors. Programs that have been designed to reduce moral disengagement overlook the long-term effects. Additionally, interventions often focus on the work environment and adolescence. In the future, interventions that include longitudinal designs considering the role of individual differences and different contexts might contribute to the relevant literature.
Mental Well-Being in Adolescence: A Systematic Review
Authors: EKİNCİ Nezir
Published: October 2023

Mental well-being is defined as an individual's awareness of his/her own potentials, making an effort to overcome the challenging experiences he/she encounters, being productive in his/her individual and social life and trying to contribute to society within the framework of his/her abilities. In this study, it is aimed to systematically review the research theses conducted to determine the variables associated with mental well-being in adolescents. For this purpose, a search was made in the National Thesis Center database using the key concept of mental well-being. As a result of the screening, 4 postgraduate theses conducted with adolescents were accessed. In the studies conducted with adolescents, the relationship between mental well-being and variables such as playing sports, time spent on social media, perceived social support, attachment to mother and father, gender, age, level of education of mother and father, perceived income level are examined. The findings of the research show that the mental well-being scores of the groups who regularly do sports and participate in social activities increase. In the studies examined, there was a significant positive relationship between the level of secure attachment to mother and father and mental well-being, and a significant negative relationship with social media time. Perceived social support was found to be a significant predictor of mental well-being in adolescents. As a result, doing regular sports, spending less time on social media, being aware of social support resources, and having secure attachment positively benefit adolescents' mental well-being levels. These results will shed light on preventive and protective guidance and counseling practices for adolescents' well-being levels.
Transition to fatherhood and adjustments in working hours: The importance of organizational policy feedback
Authors: Abendroth Anja-Kristin , Lükemann Laura
Published: October 2023

Objective: This study investigates whether the normalization of the use of the family-friendly workplace policy flexiplace in the organization affects men’s adjustments in working hours following their transition to fatherhood.
Background: Men’s stable full-time employment after childbirth remains to be a barrier to the equal distribution of care and paid work. Recent research suggests that state family policies promoting dual-earner/dual-carer family models can involve new norm setting of active fatherhood, albeit so far with only modest consequences for fathers’ working hours. Unclear is, however, whether family-friendly workplace policies, such as flexiplace, and involved organizational policy feedback are of complementary importance.
Method: We estimated fixed-effects regression analyses on men's adjustments in actual and contracted hours after a transition to fatherhood. Analyses are based on linked employer-employee panel data (2012/13; 2014/15; 2018/19) from large German work organizations, considering a random sample of 1,687 men in 131 work organizations.
Results: Findings revealed that the normalization of using flexiplace in the work organization was associated with a reduction in men’s overall working hours as well as marginal adjustments in their contracted hours after transitioning to fatherhood.
Conclusion: Although a normalization of flexiplace is more likely in demanding workplace contexts, men experience at least some leeway in adjusting extensive temporal investments to cater to private demands.
Formas da tukhē (“fortuna”) na Olímpica 12 de Píndaro e no Héracles de Eurípides
Authors: Werner Christian
Published: October 2023

Neste texto discutem-se alguns tópicos do Herácles de Eurípides em paralelo com a Olímpica 12 de Píndaro, tendo em vista que esta guarda notáveis pontos de contato com o enredo e alguns temas dessa tragédia. O objetivo principal da discussão é mostrar uma característica marcante do Héracles, a utilização de formas poéticas e temas típicos de outros gêneros líricos, sobretudo do epinício, pouco produtivo na época de composição dessa tragédia, mas que teve em Héracles um de seus heróis pan-helênicos mais recorrentes.
Research Progress in Composition, Classification and Influencing Factors of Hair
Authors: Su Qianqian , Zhou Cheng , He Congfen , Jiao Qian , Wang Zidi , Jia Yan
Published: October 2023

Human hair is a natural fiber with keratin and keratin-related proteins as a main component. Externally, hair is a thin, pliable tube of dead, fully keratinized epithelial cells, while inside the skin, it is part of a single living hair follicle. In addition to a large amount of protein, hair also contains low levels of lipids and pigments. The hair also has its own ecological balance system. Although the lipid content in hair is much lower than the protein content, it plays an important role in hair and influences hair texture to some extent. For example, prevent hair breakage and thinning; To act as a barrier to moisture loss; and improve the gloss, elasticity and tensile strength of the hair stem. Environment, hair dressing and daily care can all cause hair damage to varying degrees. Factors such as ultraviolet light and chemicals can make hair dry, rough, dull, stiff and brittle by destroying the proteins, pigment sand lipid sin the hair. In this paper, the composition, classification and influencing factors of hair were reviewed. The composition and function of lipids in hair were investigated emphatically. It aims to improve people's understanding of the physical and chemical properties and structure of hair. It provides reference value for the research and development of hair cosmetics for different hair states and washing purposes. The function of hair lipids on hair is not accurate. In addition, there is still some controversy on the existing role of hair lipids, which needs further research.
Advances in the Study of Chemical Constituents and Pharmacological Effects of Sanguis Draconis
Authors: Zhang Ying , Tao Jun-wen , Guo Miao-miao , Yu Dan , Li Li
Published: October 2023

Sanguis Draconis, the prepared resin of the fruit of Daemonorops draco Bl., is a precious traditional medicine from Southeast Asia. It has the effects of activating blood circulation and calming pain, removing blood stasis and hemostasis, generating muscle and astringeting sores. It is used for traumatic injury, abdominal stasis and pain, traumatic bleeding, etc. The chemical composition of Sanguis Draconis is complex, mainly including flavonoids, diterpenoid acids and other effective components. Modern pharmacological studies show that Sanguis Draconis has excellent pharmacological activities such as anti-inflammatory, antibacterial, anti-oxidant, anti-tumor, promoting wound healing and so on. This paper comprehensively arranges and summarizes the research status of the variety sources, chemical components and pharmacological effects of Sanguis Draconis, so as to provide scientific basis and new ideas for future research of Sanguis Draconis.
Impact of Hairdressers’ Motivation to Participate in Volunteer Activities on Job Satisfaction
Authors: Yoon Oh Sun
Published: October 2023

Purpose: This study seeks to investigate the impact of hairdressers’ motivation to participate in volunteer activities on their job satisfaction.Methods: The research subjects were hairdressers living in Gwangju Metropolitan City and Jeonlanamdo who have experience in volunteer activities, and a survey was conducted from December 1 to December 30, 2022. For data analysis, descriptive statistics, correlation, and multiple regression analyses were performed on 211 copies, excluding surveys with incomplete responses, by using the SPSS v. 25.0 Statistical Package Program. Results: The analysis showed the followingresults: First, self-development motivation, cause-directed motivation, external motivation, and leisure motivation as subfactors of the motivation to participate in volunteer activities had a statistically significant positive (+) correlation with cosmetology job satisfaction and interpersonal satisfaction as subfactors of job satisfaction (p<0.001); Second, self-development motivation and leisure motivation were found to have a statistically significant positive (+) effect on cosmetology job satisfaction; Third, leisure motivation, self-development motivation, and cause-directed motivation were found to have a statistically significant positive (+) effect on interpersonal satisfaction.Conclusion: It can be confirmed that self-development motivation and leisure motivation are important factors in hairdressers' job satisfaction as subfactors of their motivation to participate in volunteer activities. For interpersonal satisfaction, it can be confirmed that leisure motivation, self-development motivation, and cause-directed motivation are important factors among the subfactors of motivation to participate in volunteer activities.
Development of Anti-aging Cosmetics Using Chitosan/ γ-Cyclodextrin/Fucoidan Nanoparticles (Nanogel) Based on the Drug Delivery System
Authors: Choi Da-In , Ju Min-Kyeong , Park Su-Mi , Lee Sook-Young
Published: October 2023

Purpose: This study aimed to develop MARINAVI-FD, a cosmetic material containing γ-cyclodextrin/chitosan/fucoidan nanoparticles, i.e., CH-γ-CD-Fu (Nanogel) based on the DDS system, and anti-aging cosmetics that have proven antioxidant and moisturizing effects.Methods: CH-γ-CD-Fu (nanogel) was identified through electron microscope (scanning electron microscope) analysis and nanoparticle size analysis (dynamic light scattering). Radical scavenging DPPH and ABTS assays were performed. Skin keratinocytes (HaCat cells) was assessed by the MTT assay, and the moisturizing effect was evaluated through enzyme-linked immunosorbent assay. Temperature and storage conditions were checked for the stability of the formulation. In the human body application test, Moisture Meter D Compact device was used.Results: The CH-γ-CD-Fu (Nanogel) has confirmed particle size of approximately 500 nm. In the DPPH and ABTS assays, compared with Fu (foucoidan), the CH-γ-CD-Fu (nanogel) showed higher scavenging ability at treatment concentration of 15.625–500 μg/mL. CH-γ-CD-Fu (Nanogel) showed a survival rate of >80% in skin keratinocytes (HaCat cells) up to a concentration of 5,000 μg/mL. In the measurement of hyaluronic acid production, CH-γ-CD-Fu (Nanogel) showed better production at 194.87 ng/mL than at 121.47 ng/mL at a concentration of 200 μg/mL in the control group. The stability of skin and cream formulations of anti-aging cosmetics containing MARINAVI-FD was confirmed. The moisturizing effect was observed 2.5 mm depth of skin human application.Conclusion: In this study, CH-γ-CD-Fu (nanogel) was used to materialize into anti-aging cosmetics.
Evaluation of Citrus junos Essential Oil as a Promising Anti-aging Ingredient: In Vitro and Clinical Studies on Skin Health Improvement
Authors: Kim Byel , Bae Seunghee
Published: October 2023

Purpose: This study assessed Citrus junos essential oil (CJEO) as an anti-aging agent for improving skin health.Methods: CJEO was extracted from authenticated C. junos fruit peels, and its chemical composition was analyzed using a gas chromatographymass spectrometry (GC-MS). In vitro experiments were conducted on human epidermal keratinocytes (HEKs) and human dermal fibroblasts (HDFs) to evaluate CJEO’s impact on cell viability, anti-inflammatory activity, collagen synthesis, and collagen degradation. The expression of TNF-α, IL-1β, IL-6, NF-κB, MMP-1, MMP-3, COL1A1, and COL3A1 was quantified using RT-qPCR. A dermal patch test was performed on human participants to assess potential skin irritation, and clinical evaluations were conducted on 20 female participants to analyze CJEO’s effects on skin elasticity.Results: CJEO effectively inhibited nitric oxide production and significantly suppressed the expression of inflammatory markers, including TNF-α, IL-1β, IL-6, and NF-κB, as well as collagen degradation markers MMP-1 and MMP-3. Furthermore, CJEO treatment upregulated the expression of genes associated with collagen synthesis, specifically COL1A1 and COL3A1. Notably, significant improvements in skin elasticity were observed in the 20 female participants. The dermal patch test indicated excellent tolerance of the CJEO emulsion without causing irritation.Conclusions: CJEO exhibits promising potential as a bioactive ingredient in anti-aging cosmeceuticals. Its anti-inflammatory properties, ability to stimulate collagen synthesis, suggest efficacy in reducing skin aging and promoting overall skin health. Additionally, the dermal patch test confirms CJEO’s safety, supporting its suitability for use in cosmetic formulations. These findings endorse CJEO as an effective and safe component in anti-aging skincare products.
A Study on Antioxidant and Anti-inflammatory of Salvia microphylla Ethanol Extract
Authors: Choi Guen Won , Jo Hyeon Mi , Choi In Ho
Published: October 2023

Purpose: This study was aimed at investigating the anti-inflammatory and antioxidant properties of Salvia microphylla (SM) extract (SME).Methods: Powdered SM was treated with ethanol and decocted to acquire SME. The antioxidant activities of SME were assessed by evaluating its total polyphenolic, and flavonoid , contents and performing 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays. The anti-inflammatory activities of SME were verified by examining the inhibition of nitric oxide (NO) production, and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide (LPS) activated RAW 264.7 macrophages.Results: The total polyphenol and flavonoid contents in SME were 102.26±0.39 mg GAE/g and 377.42±0.77 mg QUE/g, respectively. The DPPH and ABTS assays revealed the antioxidant activities of SME by exhibiting their ability to scavenge radicals in a concentration-dependent manner (50-1000 μg/mL). The cell viability of SME exceeded 99% at 50-1000 μg/mL. The concentration-dependent reduction in the expression of the inflammation mediator iNOS and subsequent NO production indicated an approximately 100% inhibition efficacy at 600 μg/mL (0.00±1.34%). These results confirmed the potential of SME as a component of cosmeceuticals.Conclusion: Based on the findings of this study, SME is explicitly acknowledged for its applicability as a natural preservative possessing antioxidant and anti-inflammatory activities as well as a raw material for cosmeceuticals intended to alleviate skin irritation.