bluuebunny/crossref_metadata_2025 huggingface dataset:
Reverse Total Shoulder Arthroplasty in Proximal Humerus Fractures with Concomitant Nerve Injury
Authors: Katanbaf Reza , Greiwe R. Michael
Published: August 2023

Background

Axillary nerve dysfunction has been a relative contraindication for reverse total shoulder arthroplasty (RTSA) as it implies deltoid dysfunction which is necessary for a successful outcome and to maintain stability. However, most axillary nerve injuries or brachial plexus injuries in the setting of acute fracture or fracture dislocation are temporary neuropraxias. Therefore, RTSA may be a feasible option in the acute setting in patients with associated axillary/brachial plexus injury. The objective of this study is to compare results of RTSA patients with preoperative nerve injuries to patients without nerve injuries at a minimum of 2 years.

Methods

A retrospective case series of all proximal humerus fractures treated with rTSA from 2010 to 2018 by a single surgeon was performed. Inclusion criteria were patients with a diagnosis of fracture-dislocation of the proximal humerus. American Shoulder and Elbow Surgeon (ASES) scores, Simple Shoulder Test (SST) scores, range of motion (ROM) as well as complications were obtained at final follow up.

Results

A total 29 patients treated with RTSA for fracture-dislocation were identified. Five patients declined to participate in the study, 4 patients died prior to final follow-up, leaving 20 patients in the study group. Two patients were lost to follow-up leaving 18 of 20 patients (90%) with final follow up data. Seven (35%) patients presented with a brachial plexus/axillary nerve injury associated with their fracture. Average follow-up was 5.83 years (range 2-8 years). There were no differences between the two groups regarding age or body mass index (BMI). The American Society of Anesthesiologists (ASA) was higher in the group without nerve injury 2.92 +/- 0.28 vs 2.43 +/- 0.53 (P=0.0130). There was no difference in time to surgery after fracture between the 2 groups. At final follow-up, there was no difference between the 2 groups regarding shoulder ROM, ASES or SST scores. No patients experienced surgical complications, however, two patients were still reporting nerve related symptoms at final follow up.

Conclusion

Reverse total shoulder arthroplasty for fracture-dislocation in the acute setting may be a feasible option in patients with concomitant brachial plexus injury.
Managing Recurrent Clavicle Nonunion and Construct Failure: A Case Report
Authors: Jenkins Skyler , Daji Akshay , Fomunung Clyde , Grunhut Joel , Sabesan Vani
Published: August 2023

Case

A 36-year-old male who suffered a left midshaft clavicle fracture, following a fall from a mountain bike, was treated unsuccessfully with two ORIF surgeries. Smoking cessation and management of hypovitaminosis was addressed preoperatively before final revision with a dual plate construct and tibial autologous bone graft. Follow-up radiographs taken at 12 months from the initial surgery showed intact hardware and full bone healing.

Conclusion

Successful management of clavicle nonunions can be optimized through optimal plate selection, plate positioning, number of plates, construct biomechanics, biologic augmentation, and preoperative risk optimization. Efforts to minimize controllable risk factors for nonunion, such as smoking cessation or vitamin D supplementation, should be utilized both preoperatively and postoperatively.
Trapezium fracture and 1st CMC joint fracture-dislocation: a case report
Authors: Haj Shehadeh Tarek , Kawtharani Firas
Published: August 2023

The thumb and its corresponding joints are important for daily life activities. Although rare, injuries to this apparatus would greatly affect any patient’s quality of life. We present in this article a case of a man who had a traumatic trapezium-thumb metacarpal base fracture-dislocation, a pattern described in the literature with no consenus on the treatment of choice, treated with closed reduction and percutaneous pinning with excellent functional and radiological results.
Cost-Effectiveness of Bone Cement With and Without Antibiotics: A Broader Perspective
Authors: Sogard Oliver , Brown Gregory A.
Published: August 2023

Background

Periprosthetic joint infections (PJIs) and periprosthetic femur fractures (PFFs) increase total costs of care. Retrospective registry/institutional studies with selection bias and underpowered meta-analyses have corrupted the evidence base regarding antibiotic-laden bone cement (ALBC) use in total knee arthroplasties (TKAs). Clinical practice guidelines (CPGs) recommend using cement fixation of femoral components in hip fracture patients to prevent PFFs, but have no recommendations regarding ALBC. Hip osteoarthritis CPGs have no bone cement recommendations regarding prevention of PJIs or PFFs. ALBC is potentially cost-effective by reducing PJIs, PFFs, and reducing implant costs.

Methods

A systematic review was conducted to identify randomized controlled trials (RCTs), meta-analyses, and registry reports related to the efficacy of ALBC in reducing PJIs and cemented femoral fixation in reducing PFFs. Numbers needed to treat (NNT) are calculated. Cost-effectiveness margins per case are calculated.

Results

A pooled analysis of four TKA RCTs found ALBC reduces PJI by 0.94% (p=0.027), NNT 106. A total hip arthroplasty (THA) meta-analysis found ALBC reduces PJI by 0.58% (p<0.0001), NNT 172. A hip hemiarthroplasty (HH) RCT found high-dose dual-antibiotic ALBC reduces PJI by 2.35% (p=0.0474), NNT 43. A THA registry report found that cemented fixation compared to ingrowth fixation reduced PFFs by 0.44% (p<0.0001), NNT 229. A pooled analysis of three HH RCTs found that cemented femoral stem fixation reduced PFFs by 5.09% (p-0.0099), NNT 20. Mean PJI treatment costs are $80,000. Mean PFF treatment costs are $27,596. Mean HH cemented femoral stem cost reduction: $685. Using ALBC: TKA margin/case is $755; THA margin/case is $586; and HH margin/case is $3,925. Using plain bone cement: TKA margin/case is $0; THA margin/case is $121; and HH margin/case is $2,065.

Conclusions

A broader perspective demonstrates that ALBC provides significant financial margins in TKAs, THAs, and hip hemiarthroplasties. ALBC is cost-effective when including the additional costs of using ALBC in TKAs, THAs, and hip hemiarthroplasties. Hand-mixed ALBC is more cost-effective than pre-mixed ALBC in all scenarios.
Overview and considerations of access control based on attribute encryption
Authors: Hu Vincent C
Published: August 2023

Encryption technology can be incorporated into access control mechanisms based on user identities, user attributes, or resource attributes. Traditional public-key encryption requires different data to have different keys that can be distributed to users who satisfy perspective access control policies along with the encrypted version of the data. However, some distributed or pervasive system environments wish to avoid the public-key encryption’s all-or-nothing data access limitation when considering their performance requirements. Attribute-based encryption incorporates access control policies and attributes with encryption and decryption functions and a one-to-many authorization scheme that requires fewer keys than public-key encryption. It also utilizes collusion-resistance, which provides a more efficient and flexible attribute-based access control mechanism that supports high-performance systems (e.g., cloud, IoT, disrupt-tolerant networks, wireless
sensor networks, mobile ad-hoc networks, and public search service systems).
Paradox in Melanie Martinez’s Song Lyrics, “Lunchbox Friends and Fire Drill”
Authors: Rita Napitupulu  , Stefany Kangginata
Published: August 2023

This research, done is to explore about the paradox used in the song lyrics, and through the exploration will be known how and why it is used there. The research conducted by using the method of qualitative research, which does not use statistical data; it is collected in the form of written, spoken, or observed behavior. The researcher also uses the library research in the collecting data.
               Findings of this research are paradox is used by bringing order to the ambiguous shared meanings that are provided by perceptions of reality, constructing a draft to use as a guide for their future research, reformulating element of modern, industrial society, understanding the start or result of research, supporting the suitability of the goal of the research, giving space to have critical quality, amplify contrast between elements of the lyrics.
               Through this research is hoped that it can inspire the readers to deeper into the subject of paradox, spark the discussion of the paradox sentences or ideas in Martinez’s lyrics, so that the readers can have a better understanding about the paradox itself.
Perbandingan Makna Pada Peribahasa Yang Menggunakan Kata “Hati” Dalam Bahasa Mandarin Dan Bahasa Indonesia
Authors: Sinar Anwar  , Silviani Silviani
Published: August 2023

Language is unique and universal. Unique means that every language has the same characteristics that are owned by every language in the world and universal means that it has its own characteristics that are not owned by other languages. This study aims to compare the similarities and differences in meaning found in Chinese proverbs and Indonesian proverbs that use the word "heart". Researchers used a qualitative descriptive research design. The data collection technique was carried out using documentation techniques and the data sources for this research were the Xīnhuá chéngyǔ cídiǎn dictionary and the 7700 Indonesian Proverb Dictionary. The results of this study indicate that there are 10 similar meanings in Chinese proverbs and Indonesian proverbs, such as anxiety, honesty, very close relationships and others. Besides that, there are 28 different meanings in Mandarin proverbs and Indonesian proverbs, such as not concentrating, being loyal, being wise and so on. Most describe the state, feelings, behavior and character of a person.
O PAPEL DO ENFERMEIRO NA INCLUSÃO DO DOENTE MENTAL NA ATENÇÃO PRIMÁRIA DE SAÚDE.
Authors: DOS REIS CAMPOS ANDRIANA , Ângela Pestana da Silva  , Erica Marques Figueiredo  , Rita de Cassia Pereira Alves  , Rinara Lopes Negreiros Kokudai
Published: August 2023

O presente estudo visou verificar o papel do enfermeiro na Atenção Básica de Saúde com vistas a trabalhar o fortalecimento de vinculo familiar e comunitário na inclusão do doente mental na sociedade. Tendo como objetivos específicos: identificar quais as ações que visam o fortalecimento de vínculos familiares e comunitários, verificar a funcionalidade da rede de atenção psicossocial ao usuário, compreender quais os direitos básicos de saúde da pessoa com doenças mental, de forma a garantir os mesmos, além de desenvolver ações estabelecidas nas políticas públicas, identificando a rede de atenção ao usuário. Ao decorrer do artigo procurou-se esclarecer a importância do enfermeiro e toda equipe de saúde junto às redes de apoio no acolhimento para a inclusão do doente mental nas Unidades Básicas de Saúde. Ao final verificou-se que o CAPS é referência de assistência psicossocial, onde constitui a principal estratégia do processo de reforma psiquiátrica.
FAKTOR YANG MEMENGARUHI PEMAHAMAN PASIEN TERHADAP PENJELASAN INFORMED CONSENT PASIEN OPERASI DI RUMAH SAKIT KHUSUS MATA MEDAN BARU
Authors: Delfi Delfi , Asriwati Asriwati , Fitriani Arifah Devi , Theo Deli , Harahap Juliandi
Published: August 2023

Informed consent atau persetujuan tindakan medis merupakan salah satu hal yang sangat penting sebelum dilakukan tindakan operasi. Dalam pelaksanaannya setiap rumah sakit harus memliki prosedur tetap sebagai acuan. Dari survei awal pada bulan September 2021 terhadap pasien dan keluarga pasien yang sudah dilakukan tindakan operasi, pemberian informed consent masih belum sesuai dengan prosedur yang berlaku. Dari 15 orang terdapat 6 orang (40%) belum paham dengan isi dari informasi medis yang disampaikan dokter berupa risiko, komplikasi dan tindakan bedah.Desain  penelitian  ini  menggunakan  rancangan penelitian Survey Analitik pada pasien dan keluarga yang mewakili pasien yang telah dilakukan tindakan operasi di Rumah Sakit Khusus Mata Medan Baru. Populasinya  adalah  pasien dan keluarga   yang   mewakili   pasien   yang   telah   dilakukan   tindakan   operasi di Instalasi Bedah mata RSK Mata Medan Baru. Pengambilan sampel dengan metode Accidental sampling yaitu 96 orang. Pengumpulan data menggunakan kuesioner. Analisa data  menggunakan  univariat,  bivariat  dengan  uji  chi-square  dan  multivariat dengan uji Normaltas, Multiolinearitas, Heteroskedastisitas, Koefisien Determinasi (Adjusted R2), Signifikansi Nilai F dan Uji Signifikan Nilai t. Hasil  penelitian  menunjukan  bahwa tingkat  pemahaman pasien  terhadap penjelasan informed consent operasi dalam kategori paham (83,4%) dan kategori sangat paham (15,6%). Hasil dari uji chi-square berdasarkan beberapa karakteristik (pasien, akses informasi, Bahasa Penyampaian, dan Faktor Psikologi) terdapat hubungan antara informed consent terhadap Pemahaman pasien yang akan dioperasi, kecuali berdasarkan karakteristik pasien.Hasil dari analisis multivariat dikatakan bahwa penelitian ini terdistribusi Normal dan Baik, diterima, dan cukup ketepatannya.Kesimpulannya adalah sebagian besar tingkat pemahaman pasien terhadap penjelasan informed consent operasi dalam kategori paham dan faktor yang secara signifikan memengaruhi  pemahaman  pasien  adalah  faktor  akses informasi  berupa  waktu penyampaian   informasi dan Psikologi Pasien.   Saran   yang   diberikan   adalah  waktu penyampaian informasi sebaiknya 1 hari sebelum tindakan operasi dilakukan dan Menertibkan pelaksanaan penjelasan informed consent operasi sesuai dengan peraturan yang berlaku
PENGOLAHAN SAMPAH ORGANIK RUMAH TANGGA MENGGUNAKAN LOSIDA (LODONG SISA DAPUR) DI DUSUN PISANGAN SLEMAN DAERAH ISTIMEWA YOGYAKARTA
Authors: Haliza Layla Nur , Citra Binar Elvinda , Primadani Nadia Belqis Zevi , Situmorang Elizabeth Elen Br , Khaeron Ubaidulah , Rubaya Agus Kharmayana , Kadarusno Abdul Hadi
Published: August 2023

Penelitian ini dilatarbelakangi tentang pengolahan sampah. Sampah merupakan sisa-sisa kegiatan yang dibuang dari hasil aktivitas manusia maupun proses alam yang tidak memiliki nilai ekonomis. Salah satu hasil aktivitas manusia yang sering terjadi adalah limbah rumah tangga. Berdasarkan hasil wawancara dan observasi yang dilakukan di Dusun Pisangan Tridadi Sleman diperoleh informasi bahwa masih banyak sampah organik khususnya limbah rumah tangga. Tujuan dari penelitian ini dengan mengadakan kegiatan edukasi pengolahan limbah rumah tangga yang dimanfaatkan sebagai media pembuatan LOSIDA. Edukasi ini memberikan pengetahuan mengenai LOSIDA itu sendiri dan membantu masyarakat dalam mengurangi penumpukan sampah pada rumah tangga. Penelitian ini menggunakan metode dalam memberikan edukasi mengenai LOSIDA ini menggunakan ceramah, demonstrasi, dan praktek pemasangan LOSIDA. Kegiatan ini bertempat di Kediaman Bapak Dukuh Pisangan pada 27 Januari 2023 dan diikuti oleh ibu-ibu kader perwakilan RT dengan jumlah 14 peserta. Materi yang dipaparkan pada penyuluhan ini adalah pemanfaatan limbah sisa dapur menggunakan LOSIDA, dengan output pupuk organik (pupuk cair dan kompos). Dalam kegiatan penyuluhan mahasiswa juga turut mengajak peserta untuk membuat LOSIDA sederhana dengan memanfaatkan botol bekas yang telah disiapkan oleh masing-masing peserta. Berdasarkan kegiatan penyuluhan dan praktik pengolahan sampah dengan pembuatan LOSIDA (Lodong Sisa Dapur) telah dilaksanakan di Dusun Pisangan dengan baik dan mendapatkan tanggapan yang positif, warga juga antusias dalam memperhatikan penyuluhan dan mempraktikan pembuatan Losida untuk pemanfaatan limbah sisa dapur yang dihasilkan setiap harinya.
EFEKTIFITAS PENGENCANGAN MUSCULUS TRANVERSUS ABDOMONIS TERHADAP KECEPATAN PENGELUARAN URINE PADA IBU POST PARTUM DI PMB SENANG AM.KEB KABUPATEN BANYUASIN
Authors: Solekah Umi , Mariyam Mariyam , Nabila Putri
Published: August 2023

Pengencangan Musculus Tranversus Abdominis merupakan latihan yang dilakukan oleh ibu post partum untuk menjaga otot abdominal agar menjadi lebih kuat setelah melewati proses persalinan. Penelitian ini bertujuan untuk mengetahui Efektifitas Pengencangan Musculus Tranversus Abdominis Terhadap Kecepatan Pengeluaran Urine Pada Ibu Post Partum Di PMB Senang AM.Keb Kabupaten Banyuasin. Penelitian ini bersifat Survey Analitik dengan menggunakan metode Case Control. Populasi penelitian ini adalah seluruh ibu post partum dengan total jumlah sampel 6 Responden. Jenis Tekhnik pengambilan data dalam penelitian ini yaitu menggunakan Accidental Sampling. Ibu post partum yang dilakukan Pengencangan Musculus Tranversus Abdominis sebanyak 3 responden (50,0%), yang tidak dilakukan sebanyak 3 responden (50,0%). Dengan menggunanakn Uji T-Independent didapatkan p_value = 0,002 < ? (0,05) yang berarti Ada Perbedaan Rata-Rata Pengencangan Musculus Tranversus Abdominis Terhadap Kecepatan Pengeluaran Urine Pada Ibu Post Partum Di PMB Senang AM.Keb Kabupaten Banyuasin.  Disarankan untuk petugas kesehatan yang melakukan pelayanan kesehatan di PMD Senang AM.Keb Kabupaten Banyuasin agar dapat memperhatikan Kecepatan Pengeluaran Urine Pada Ibu Post partum.
PENGARUH HIPERTENSI DAN ANEMIA PADA KEHAMILAN TERHADAP PENINGKATAN KEJADIAN BERAT BAYI LAHIR RENDAH: STUDI CASE CONTROL
Authors: Annisa Dinda Mega , Riyanto Riyanto , Islamiyati Islamiyati
Published: August 2023

Berat bayi lahir rendah masih mendominasi penyebab morbiditas dan mortalitas perinatal. Ibu hamil dengan hipertensi dan anemia cenderung melahirkan BBLR. Penelitian ini bertujuan menganalisis pengaruh hipertensi dan anemia pada ibu hamil dengan kejadian BBLR di Rumah Sakit Mardi Waluyo Metro.  Studi case control dengan pendekatan retrospective merupakan desain penelitian yang dipilih. Sampel penelitian ini terdiri atas kelompok kasus adalah bayi lahir dengan berat bayi lahir rendah dan kelompok kasus adalah baru lahir dengan berat bayi lahir normal. Perbandingan kelompok kasus dan kelompok adalah 1 : 2 atau 29 kasus dan 58 kontrol yang diambil dengan teknik consecutive sampling. Sumber data bersumber dari catatan medik rumah sakit yang memenuhi kriteria penelitian. Pengumpulan data meliputi BBLR atau tidak (variabel dependen) serta hipertensi dan anemia pada kehamilan atau tidak (variabel independen). Data dianalisis menggunakan uji chi square dengan tingkat tingkat kemaknaan (?) 0,05. Ditemukan hasil penelitian secara statistik ada hubungan hipertensi dengan kejadian BBLR (p = 0,02; OR = 3,367; CI 95% 1,309-8,660) dan ada hubungan anemia dalam kehamilan dengan kejadian BBLR (p = 0,012; OR = 3,610 95%; CI 1,413-9,221). Kesimpulan penelitian menemukan bahwa faktor hipertensi dan anemia pada ibu hamil menjadi faktor yang meningkatkan kejadian BBLR. Perlu mengatasi anemia pada ibu hamil dan mengontrol tekanan darah pada ibu hamil untuk menurunkan kejadian BBLR.

Low birth weight babies still dominate the causes of perinatal morbidity and mortality. Pregnant women with hypertension and anemia tend to deliver LBW. This study aims to analyze the effect of hypertension and anemia on pregnant women with LBW events at Mardi Waluyo Metro Hospital in 2018. A case-control study with a retrospective approach is the chosen research design. The sample of this study consisted of the case group which were babies born with low birth weight and the case group were newborns with normal birth weight. Comparison of the case and group is 1: 2 or 29 cases and 58 controls taken by consecutive sampling technique. The data source comes from hospital medical records that meet the research criteria. Data collection included LBW or not (the dependent variable) and hypertension and anemia during pregnancy or not (the independent variable). Data were analyzed using the chi-square test with a significance level (?) of 0.05. The research results found that statistically there was a relationship between hypertension and the incidence of LBW (p = 0.02; OR = 3.367; 95% CI 1.309-8.660) and there was a relationship between anemia in pregnancy and the incidence of LBW (p = 0.012; OR = 3.610 95%; CI 1.413-9.221). The conclusion of the study found that hypertension and anemia in pregnant women were factors that increased the incidence of LBW. Need to overcome anemia in pregnant women and control blood pressure in pregnant women to reduce the incidence of LBW.
PENGARUH PEER GROUP COUNSELOR TERHADAP PENGETAHUAN REMAJA MEMBERIKAN INFORMASI KESEHATAN REPRODUKSI
Authors: Ardhiyanti Yulrina
Published: August 2023

Masa remaja merupakan masa peralihan dari anak-anak ke masa dewasa. Berbagai penelitian menunjukkan bahwa remaja mempunyai permasalahan yang sangat kompleks seiring dengan masa transisi yang dialami remaja. Masalah yang menonjol di kalangan remaja yaitu permasalahan seputar TRIAD KRR (Seksualitas, HIV dan AIDS serta NAPZA), rendahnya pengetahuan remaja tentang kesehatan reproduksi remaja dan median usia kawin pertama perempuan relatif masih rendah yaitu 19,8 tahun. Beberapa remaja mendapat informasi tentang kesehatan reproduksi melalui diskusi dengan teman sebaya Kondisi sampai saat ini, kebanyakan remaja mendapatkan informasi yang salah atau tidak lengkap mengenai kesehatan reproduksi. Permasalahannya, informasi yang diberikan oleh teman sebaya sering kali tidak tepat, penuh rumor dan kesalahpahaman. Tujuan dari tinjauan literatur ini untuk mengetahui pengaruh peer group counselor terhadap pengetahuan remaja memberikan informasi kesehatan reproduksi. Penelitian ini merupakan studi literatur dengan menggunakan sumber data berdasarkan studi literatur dari database Google Scholar dalam lima tahun terakhir. Terdapat pengaruh peer group counselor terhadap pengetahuan remaja memberikan informasi kesehatan reproduksi. Kesimpulan dari literature review adalah  pendidikan teman sebaya (peer group counselor) efektif meningkatkan pengetahuan tentang kesehatan reproduksi remaja dan keterampilan dalam memberikan informasi/konseling tentang kesehatan reproduksi remaja.
The Effect of Promotion on Consumer Purchase Decisions for GrabFood (Study in The City of Tasikmalaya)
Authors: Nopebrianti Novi , Putri Ramadhani Audry
Published: August 2023

Grab companies must be able to compete, because consumer needs are increasingly complex and in order to attract the attention of consumers. There are several factors that consumers consider when making a purchase on Grab, one of which is promotion. This study aims to determine how promotion influences the purchasing decisions of GrabFood consumers in Tasikmalaya City. This study uses a quantitative approach and data collection methods using a questionnaire with a sample of 158 respondents in the City of Tasikmalaya. The analytical technique used is reliability test, descriptive analysis test, correlation test, normality test, linearity test, simple linear regression test and coefficient of determination test using SPSS 25. Based on the results of data analysis, it can be concluded that there is a positive promotion effect on GrabFood customer purchasing decisions, this means that if the promotion is increased, the purchase decision will also increase.
Analysis Of The Effect Of Product Diversity On Consumer Buying Decision At The Borma Department Store in Bandung
Authors: Al Bukhori Gina Nurlatipah Perawati
Published: August 2023

This study aims to determine the effect of product diversity on consumer purchasing decisions in the city of Bandung, Indonesia. Respondents came from consumers who bought their various needs at the modern market closest to their place of residence, namely the Toserba Borma, Bandung City. This study uses quantitative descriptive methods, validity and reliability tests, normality tests, and data analysis using simple linear regression. The sample in this study was 113 respondents. Data was collected by distributing questionnaires to respondents who met the criteria. The results showed that the diversity of products in Borma, Bandung City is very significant on the buying interest of Borma consumers. This means product diversity can improve purchasing decisions.
The Effect of the Work Environment on Employee Performance at Panca Sakti University Bekasi
Authors: Tesmanto Joni , Rina Nova
Published: August 2023

This study aims to determine how much influence the work environment has on employee performance at Panca Sakti University Bekasi, Indonesia partially. This research belongs to the type of quantitative descriptive research. The population in this study were all employees at Panca Sakti University Bekasi, totaling 121 employees. The sampling technique is cluster sampling where a portion of the population is used as a sample, totaling 57 people. The analytical method used is simple linear regression analysis, correlation coefficient, t test, and coefficient of determination. The conclusions of this study are, 1) The results of simple linear regression analysis can be seen that the Work Environment variable has a significant influence on employee performance at Panca Sakti University Bekasi this is indicated by the regression value Y = 0.784 + 0.612 which means that the work environment variable has an influence which is significant to employee performance., 2) The correlation coefficient value is 0.648 which lies between -1 0.538 +1. That is, the value of the correlation coefficient (r) indicates that the relationship between the two variables is strong and positive, meaning that the work environment has an effect on improving employee performance. 3) The results of the t-test analysis, obtained by 5.751 while the t-table is 1.458 because t-count is greater than t-table means H0 is rejected and Ha is accepted. 4) Analysis of the coefficient of determination obtained the coefficient of determination of r = 0.319
Pengaruh Harga Terhadap Keputusan Pembelian Konsumen Pada Nanostore di Kabupaten Subang
Authors: Mulyadi
Published: August 2023

Penelitian ini bertujuan untuk menganalisis harga yang mempengaruhi keputusan pembelian konsumen pada nanostore di Kabupaten Subang. Responden berasal dari konsumen nanostore yang berdomisili di Kabupaten Subang dan berbelanja di nanostore sebulan terakhir. Total sampel penelitian berjumlah 102 responden. Penelitian menggunakan metode deskriptif kuantitatif dan data diolah menggunakan program SPSS 20. Selain itu, data dianalisis menggunakan uji regresi linear sederhana, uji korelasi sederhana, uji hipotesis, koefisien determinasi, dan uji chi-square. Uji hipotesis dilakukan melalui pendekatan klasik dan probabilistik. Hasil analisis deskriptif kuantitatif menunjukkan bahwa harga berpengaruh signifikan terhadap keputusan pembelian konsumen. Hal ini menunjukkan bahwa konsumen dalam membuat keputusan pembelian memperhatikan dari segi harga. Dengan begitu, para pemilik usaha nanostore perlu mempertimbangkan harga yang ditetapkan pada produk-produk yang mereka jual.
Analisis Pengaruh Kualitas Website Terhadap Keputusan Pembelian di Usaha Mikro Kecil Menengah
Authors: - Rafi Sulthan Rahman Majid
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas website terhadap keputusan pembelian pada berbagai kelompok. Responden berasal dari orang-orang yang aktif secara daring dengan persyaratan minimal satu jam. Dan orang-orang yang mempunyai ikatan dengan penulis, seperti teman, saudara, tetangga, dll. Penelitian ini menggunakan metode deskriptif kuantitatif, uji validitas dan reliabilitas, uji normalitas, dan analisis data menggunakan regresi linier sederhana. Sampel dalam penelitian ini sebanyak 112 responden. Pengumpulan data dilakukan dengan menyebarkan kuesioner kepada responden melalui Google Form. Hasil penelitian menunjukkan bahwa kualitas website berpengaruh sangat signifikan terhadap keputusan pembelian. Artinya, kualitas website dapat meningkatkan keputusan pembelian.
Pengaruh Aksesibilitas dan Fasilitas terhadap Kepuasan Konsumen Halsean Coffee & Resto
Authors: Valerina R. Muthia , Adysholihah F. Rina
Published: August 2023

Saat ini, menikmati kopi sudah menjadi lifestyle bagi masyarakat, hal tersebut membuat coffee shop menjadi salah satu bisnis yang menjanjikan di Indonesia. Namun tidak bisa dipungkiri, para pelaku bisnis harus memperhatikan faktor penunjang seperti akses, fasilitas dan faktor lainnya dalam membangun sebuah coffee shop. Maka dari itu, penelitian ini dibuat dengan tujuan untuk memeriksa pengaruh aksesisibilitas, fasilitas, dan kepuasan konsumen pada Halsean Coffee & Resto. Penelitian ini menggunakan metode eksplanatori dengan pendekatan kuantitatif. Sebanyak 300 pengunjung Halsean Coffee & Resto di daerah Cimahi dan sekitarnya terlibat dalam penelitian ini. Analisis data pada penelitian ini menggunakan analisis  frekuensi,  analisis  faktor,  analisis  normalitas  data,  dan  analisis regresi sederhana dengan bantuan software SPSS v.24. Hasil analisis data didapatkan bahwa aksesibilitas memiliki arah yang negatif dan tidak signifikansi terhadap kepuasan konsumen, sebaliknya fasilitas memiliki arah yang positif dan signifikan terhadap kepuasan konsumen.
Pengaruh Sosial Media Pada Perkembangan E-Commerce di Lingkungan Mahasiswa
Authors: Yoga Bagus Pratama
Published: August 2023

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh sosial media terhadap perkembangan e-commerce di lingkungan mahasiswa. Penelitian ini menggunakan penelitian survei deskriptif. Populasi untuk penelitian ini adalah mahasiswa. Teknik pengambilan data menggunakan kuesioner dengan jumlah pengisi sebanyak 113 responden. Metode analisis yangidgunakan adalah analisis regresi linear sederhana yang bertujuan untuk menemukan pengaruh variable x (sosial media) dengan variable y (e-commerce). Hasil dari analisis tersebut dari masing masing table adalah bahwa variable x (sosial media) memiliki pengaruh terhadap variable y (e-commerce) sebesar 35,8%.
Analisis Kualitas Layanan Self-Service terhadap Kepuasan Pelanggan di Restoran All You Can Eat Kota Bandung, Indonesia
Authors: Sundari Dwi Jayanti
Published: August 2023

Penelitian ini memiliki tujuan untuk mengetahui pengaruh kualitas layanan self service terhadap kepuasan pelanggan restoran All You Can eat kota Bandung. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kuantitatif dengan pengambilan data kuisioner menggunakan Google Form kepada 100 orang. Teknik sampling yang digunakan dalam penelitian ini adalah purposive sampling. Hasil penelitian menunjukkan bahwa variabel functional (X1), enjoyment (X2), assurance (X3), dan convenience (X4) memiliki pengaruh signifikan terhadap kepuasan pelanggan Restoran All You Can Eat Kota Bandung.
Pengaruh Influencer Marketing terhadap Keputusan Pembelian Baso Aci Akang Bandung, Indonesia
Authors: Isna Amelia Nurhamidah
Published: August 2023

Tujuan dari penelitian ini adalah mengetahui ada tidaknya pengaruh dari influencer marketing terhadap keputusan pembelian konsumen Baso Aci Akang Bandung serta mengetahui seberapa besar pengaruh tersebut. Penelitian meggunakan metode survei deskriptif yaitu penelitian dilakukan dengan menyebarkan kuisioner melalui g-form kepada responden. Responden berjumlah 100 orang dan pernah melakukan pembelian baso aci akang Bandung. Pengolahan data dilakukan menggunakan metode uji normalitas, uji linearitas dan analisis regresi linear sederhana. Hasil yang didapatkan menunjukkan bahwa  influencer marketing memiliki pengaruh positif dan signifikan sebesar 43,8% terhadap keputusan pembelian di baso aci akang Bandung. Nilai tersebut diketahui dengan melihat kolom R Square atau koefisien determinasi dalam tabel hasil analisis regresi linear sederhana. Selain itu, terdapat korelasi yang kuat antara kedua variabel. Dari hasil analisis regresi sederhana diperoleh koefisien korelasi yang dapat dilihat dari tabel R dengan besar 0,662. Nilai ini menunjukkan hubungan antara influencer marketing dengan keputusan pembelian termasuk dalam kategori kuat karena berada pada rentang 0,41 – 0,70.
Pengaruh Media Sosial terhadap Proses Pengambilan Keputusan Pembelian Pelanggan pada Usaha Kecil Sajodo Snack Bandung, Indonesia
Authors: Amini Dini Nasya
Published: August 2023

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis pengaruh dari sosial media terhadap proses pengambilan keputusan pembelian  pelanggan pada Usaha Kecil Sajodo Snack. Metode penelitian deskriptif kuantitatif, dengan data primer yang dikumpulkan melalui penyebaran kuisoner kepada 110 responden, dan analisis menggunakan deskriptif, korelasi, dan regresi berganda. Hasil penelitian menunjukan bahwa penggunaan  sosial media mempunyai pengaruh terhadap proses pengambilan keputusan pembelian  pelanggan pada Usaha Kecil Sajodo Snack secara signifikan dengan Sig. 0.000.  Penelitian ini menunjukan penggunaan media sosial memiliki pengaruh yang positif dan kuat terhadap proses pengambilan keputusan pembelian sebesar 55,8%.
Pengaruh Loyalitas Konsumen Terhadap Minat Pembelian Ulang Pada Produk Winmilk di Kota Cimahi, Indonesia
Authors: Amin Lisana Sidqin Alya
Published: August 2023

Tujuan Artikel penelitian ini disusun dengan tujuan untuk mencari tahu dan menganalisis pengaruh dari loyalitas konsumen terhadap minat pembelian ulang pada produk Winmilk di Kota Cimahi. Metode penelitian yang digunakan adalah deskriptif kuantitatif. Populasi dalam penelitian ini adalah seluruh konsumen Winmilk di Kota Cimahi. Teknik pengumpulan data dilakukan dengan penyebaran kuesioner (gform) kepada 105 orang responden. Metode analisis yang digunakan adalah Uji Validitas dan Reliabilitas, Normalitas, Regresi sederhana, dan Uji Hipotesis. Hasil penelitian menunjukkan bahwa loyalitas konsumen berpengaruh positif terhadap minat beli ulang konsumen pada produk makanan Winmilk di Kota Cimahi. Loyalitas konsumen memberikan kontribusi sebesar 61% terhadap minat beli ulang konsumen dari penelitian ini.
Pembuatan Website Program Studi Akuntansi Universitas Pembangunan Panca Budi Medan Dengan Menggunakan Codeigniter 3
Authors: Arpan
Published: August 2023

Dengan semakin berkembangnya teknologi informasi serta pemanfaatan media informasi, maka pada Prorgram Belajar Merdeka-Kampus Merdeka atau (MBKM) akan dilakukan pembauatan website program studi akuntansi Universitas Pembangunan Panca Budi Medan dengan menggunakan PHP dan database MySQL. Sistem ini bertujuan untuk mempermudah mendapatkan informasi mengenai program studi akutansi Pembangunan Panca Budi . sistem ini dibuat secara sederhana agar dapat mudah dimengerti . Website ini mempunyai fitur-fitur seperti Home, Data dosen, Kurikulum, Organisasi, Kegiatan Jumlah Mahasiswa aktif , Akreditas , Kontak Biro Hingga Jam Operasional. Dengan dibuatnya website ini sebagai sarana untuk promosi dan publikasi agar dapat diakses kapan dan dimanapun oleh mahasiswa hingga masyarakat umum sehingga dapat digunakan untuk mencari informasi mengenai program studi akuntansi.
Simultaneous diagnosis and resection of orofacial rhabdomyosarcoma with frozen section biopsy: a case report
Authors: Choi Youngwoong , Sung Ki Pyo , Lee Soo Hyang
Published: August 2023

Rhabdomyosarcoma is the most common soft tissue sarcoma in children, accounting for 4.5% of all cases of cancer in childhood. Although the head and neck are the most common sites of rhabdomyosarcoma, oral lesions are relatively rare and account for only 10% to 12% of head and neck rhabdomyosarcoma cases. This is a case report of a girl aged 2 years and 1 month who initially presented with an upper lip mass that invaded the oral mucosa, oral skin, and nostril skin, causing narrowing of the airway. Through our case, we show that rapidly growing small round cell malignancies, especially rhabdomyosarcoma, can be effectively diagnosed and treated at the same time using primary resection with intraoperative frozen section biopsy and that the time spent waiting for the results of preoperative biopsy can be saved in this way, particularly when the patient’s symptoms are intensifying rapidly and require immediate operation.
The cover of an ear thermometer probe as a split-thickness skin graft mold in external auditory canal reconstruction
Authors: Lee Chae Rim , Yoon Sungyeon , Kim Ji Hun , Choi Jangyoun , Park Kyoung Ho , Oh Deuk Young
Published: August 2023

Maintaining the patency of the external auditory canal (EAC) during reconstruction is important because of its physiological role in hearing and immunological protective functions. The curved shape of the EAC presents a challenge when performing a skin graft. One of the key points for a successful skin graft is to ensure compression on the wound bed, and many novel methods, including prefabricated ear molds, have been reported for this purpose. In this study, we present a case of a skin graft performed to reconstruct a skin defect following excision of actinic keratosis in the EAC, using the cover of an ear thermometer probe as a mold for the graft to match the curvature of the EAC. This is an economical and practical method for secure compression dressing of a skin graft in the EAC.
Clinical analysis of factors affecting the failure of free flaps used in head and neck reconstruction
Authors: Lim Beom Jin , Shin Jin Yong , Roh Si-Gyun , Lee Nae-Ho , Chung Yoon Kyu
Published: August 2023

Background: Free tissue transfer is the preferred method of reconstructing head and neck defects, with a success rate of approximately 95%. Although flap failure is uncommon, it has a major impact on patient morbidity and diminishes quality of life, making it is important to investigate the causes of flap failure.Methods: This retrospective chart review analyzed patients who underwent free tissue transfer during head and neck reconstruction at a single institution between 2016 and 2021.Results: During the study period, 58 patients underwent 60 free flap procedures. Revision surgery was needed in 14 patients. Subsequent free flap surgery was performed in one patient, and three free flaps (5%) could not be salvaged. Cardiovascular disease was significantly associated with flap failure, and venous congestion (thrombosis) was the most common reason for revision surgery.Conclusion: Cardiovascular disease clearly emerged as a factor related to the failure of free flap surgery, and this issue warrants particular attention in patients for whom free tissue transfer is planned.
Urgent appeal to allow all professional nurses and midwives to prescribe pre-exposure prophylaxis (PrEP) in South Africa
Authors: Joseph Davey D L , Wilkinson L , Grimsrud A , Nelson A , Gray A , Raphael Y , Wattrus C , Pillay Y , Bekker L-G
Published: August 2023

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Streamlining regulatory processes for health researchers: To what extent does POPIA apply?
Authors: Bronstein V , Nyachowe D T
Published: August 2023

Personal information in health research commands utmost protection while also preserving the growth of health research. This paper aims to establish which legislation applies when processing personal information for health research. South Africa regulates health research on human subjects through a network of Human Research Ethics Committees. The Protection of Personal Information Act No. 4 of 2013 (POPIA)  has recently come into force. Section 2(3)(b) of POPIA provides that POPIA does not apply where other legislation creates ‘more extensive’ conditions for the lawful processing of personal information than Chapter 3 of POPIA does. We show that the provisions of the sectoral legislation on health are more extensive than the conditions in Chapter 3 of POPIA and hence the sectoral legislation prevails. This simplifies the regulation of health research. One of the implications of this finding is that the definition of broad consent in the sectoral legislation for health research should be applied to the exclusion of the consent provisions in POPIA.
Biosensor-integrated transposon mutagenesis reveals rv0158 as a coordinator of redox homeostasis in Mycobacterium tuberculosis
Authors: Shee Somnath , Veetil Reshma T , Mohanraj Karthikeyan , Das Mayashree , Malhotra Nitish , Bandopadhyay Devleena , Beig Hussain , Birua Shalini , Niphadkar Shreyas , Nagarajan Sathya Narayanan , Sinha Vikrant Kumar , Thakur Chandrani , Rajmani Raju S , Chandra Nagasuma , Laxman Sunil , Singh Mahavir , Samal Areejit , Seshasayee Aswin N , Singh Amit
Published: August 2023

Mycobacterium tuberculosis (Mtb) is evolutionarily equipped to resist exogenous reactive oxygen species (ROS) but shows vulnerability to an increase in endogenous ROS (eROS). Since eROS is an unavoidable consequence of aerobic metabolism, understanding how Mtb manages eROS levels is essential yet needs to be characterized. By combining the Mrx1-roGFP2 redox biosensor with transposon mutagenesis, we identified 368 genes (redoxosome) responsible for maintaining homeostatic levels of eROS in Mtb. Integrating redoxosome with a global network of transcriptional regulators revealed a hypothetical protein (Rv0158) as a critical node managing eROS in Mtb. Disruption of rv0158 (rv0158 KO) impaired growth, redox balance, respiration, and metabolism of Mtb on glucose but not on fatty acids. Importantly, rv0158 KO exhibited enhanced growth on propionate, and the Rv0158 protein directly binds to methylmalonyl-CoA, a key intermediate in propionate catabolism. Metabolite profiling, ChIP-Seq, and gene-expression analyses indicate that Rv0158 manages metabolic neutralization of propionate toxicity by regulating the methylcitrate cycle. Disruption of rv0158 enhanced the sensitivity of Mtb to oxidative stress, nitric oxide, and anti-TB drugs. Lastly, rv0158 KO showed poor survival in macrophages and persistence defect in mice. Our results suggest that Rv0158 is a metabolic integrator for carbon metabolism and redox balance in Mtb.
The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2
Authors: Chen Hsiao-Fan , Wang Wei-Jan , Chen Chung-Yu , Chang Wei-Chao , Hsueh Po-Ren , Peng Shin-Lei , Wu Chen-Shiou , Chen Yeh , Huang Hsin-Yu , Shen Wan-Jou , Wang Shao-Chun , Hung Mien-Chie
Published: August 2023

The Coronavirus Disease 2019 (COVID-19) pandemic continues to infect people worldwide. While the vaccinated population has been increasing, the rising breakthrough infection persists in the vaccinated population. For living with the virus, the dietary guidelines to prevent virus infection are worthy of and timely to develop further. Tannic acid has been demonstrated to be an effective inhibitor of coronavirus and is under clinical trial. Here we found that two other members of the tannins family, oligomeric proanthocyanidins (OPCs) and punicalagin, are also potent inhibitors against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with different mechanisms. OPCs and punicalagin showed inhibitory activity against omicron variants of SARS-CoV-2 infection. The water extractant of the grape seed was rich in OPCs and also exhibited the strongest inhibitory activities for viral entry of wild-type and other variants in vitro. Moreover, we evaluated the inhibitory activity of grape seed extractants (GSE) supplementation against SARS-CoV-2 viral entry in vivo and observed that serum samples from the healthy human subjects had suppressive activity against different variants of SARS-CoV-2 Vpp infection after taking GSE capsules. Our results suggest that natural tannins acted as potent inhibitors against SARS-CoV-2 infection, and GSE supplementation could serve as healthy food for infection prevention.
Inositol Pyrophosphate Dynamics Reveals Control of the Yeast Phosphate Starvation Program Through 1,5-IP8 and the SPX Domain of Pho81
Authors: Chabert Valentin , Kim Geun-Don , Qiu Danye , Liu Guizhen , Mayer Lydie Michaillat , Muhammed Jamsheer K. , Jessen Henning Jacob , Mayer Andreas
Published: August 2023

Eukaryotic cells control inorganic phosphate to balance its role as essential macronutrient with its negative bioenergetic impact on reactions liberating phosphate. Phosphate homeostasis depends on the conserved INPHORS signaling pathway that utilizes inositol pyrophosphates (IPPs) and SPX receptor domains. Since cells synthesize various IPPs and SPX domains bind them promiscuously, it is unclear whether a specific IPP regulates SPX domains in vivo, or whether multiple IPPs act as a pool. In contrast to previous models, which postulated that phosphate starvation is signaled by increased production of the IPP 1-IP
7
, we now show that the levels of all detectable IPPs of yeast, 1-IP
7
, 5-IP
7
and 1,5-IP
8
, strongly decline upon phosphate starvation. Among these, specifically the decline of 1,5-IP
8
triggers the transcriptional phosphate starvation response, the PHO pathway. 1,5-IP
8
inactivates the cyclin-dependent kinase inhibitor Pho81 through its SPX domain. This stimulates the cyclin-dependent kinase Pho85-Pho80 to phosphorylate the transcription factor Pho4 and repress the PHO pathway. Combining our results with observations from other systems we propose a unified model where 1,5-IP
8
signals cytosolic phosphate abundance to SPX proteins in fungi, plants, and mammals. Its absence triggers starvation responses.Cytosolic P
i
is of prime importance for cellular bioenergetics because P
i
influences free energy of nucleotide hydrolysis and the metabolite fluxes through glycolysis and oxidative phosphorylation. Eukaryotic cells use the INPHORS pathway to signal P
i
via SPX domains and their ligands, inositol pyrophosphates (IP
7
, IP
8
), which control P
i
homeostasis through a network of target proteins that import, export, store or detoxify P
i
. Studies with different systems failed to yield a coherent model on this regulation.We performed the first time-resolved profiling of the full isomer spectrum of inositol pyrophosphates in yeast and dissected the isomer that is relevant to intracellular P
i
signaling. Our results can be combined with existing observations from plants, mammals, and other fungi to support a unified model of P
i
signaling across all eukaryotic kingdoms, which is in accord with the fundamental importance of P
i
management for metabolism.
Physiological and metabolic insights into the first cultured anaerobic representative of deep-sea Planctomycetes bacteria
Authors: Zheng Rikuan , Wang Chong , Liu Rui , Cai Ruining , Sun Chaomin
Published: August 2023

Planctomycetes bacteria are ubiquitously distributed across various biospheres and play key roles in global element cycles. However, few deep-sea Planctomycetes members have been cultivated, limiting our understanding of Planctomycetes in the deep biosphere. Here, we have successfully cultured a novel strain of Planctomycetes (strain ZRK32) from a deep-sea cold seep sediment. Our genomic, physiological, and phylogenetic analyses indicate that strain ZRK32 is a novel species, which we propose be named: Poriferisphaera heterotrophicis. We show that strain ZRK32 replicates using a budding mode of division. Based on the combined results from growth assays and transcriptomic analyses, we found that rich nutrients, or supplementation with NO3- or NH4+ promoted the growth of strain ZRK32 by facilitating energy production through the tricarboxylic acid cycle and the Embden-Meyerhof-Parnas glycolysis pathway. Moreover, supplementation with NO3- or NH4+ induced strain ZRK32 to release a bacteriophage in a chronic manner, without host cell lysis. This bacteriophage then enabled strain ZRK32, and another marine bacterium that we studied, to metabolize nitrogen through the function of auxiliary metabolic genes. Overall, these findings expand our understanding of deep-sea Planctomycetes bacteria, while highlighting their ability to metabolize nitrogen when reprogrammed by chronic viruses.