bluuebunny/crossref_metadata_2025 huggingface dataset:
A 4-Year Consecutive Study of Post-Tonsillectomy Haemorrhage
Authors: Attner Per , Haraldsson Per-Olle , Hemlin Claes , Hessén Söderman Anne-Charlotte
Published: October 2009

Objective: To analyse consecutive material over a period of 4 years concerning the incidence and consequences of post-tonsillectomy haemorrhages (PTH). Design: Prospective study. Setting: University hospital. Participants: All non-oncological cases of tonsillectomy (TE) and adenotonsillectomy (TA) performed at the ENT department at the Karolinska University Hospital between March 2000 and April 2004. Main Outcome Measures: Rate, timing and classification of PTH. Results: During the study period, 2,813 cases (mean age 13 ± 12.8 years; SD) of TE and TA were included. The majority (62%) were children aged below 12 years, and 69% were performed as day surgery. In total, 212 (7.5%) patients were readmitted due to PTH, of which 98 (3.4%) presented with ongoing haemorrhage. The rates of primary and secondary bleeding were 1.9 and 5.5%, respectively. The PTH occurred in 0–19 days post-operatively, in a typical twin peak mode around the day of surgery and then days 4–7. No case of serious PTH was noted. Multiple bleedings (2–3 times) occurred in 19 patients. Only a minority (31%) of the single PTH patients required active treatment, surgery in the theatre (35 patients) or diathermy under local anaesthesia in the emergency room (24 patients). However, almost all received systemic haemostatic treatment. Three patients required blood transfusion due to repeated PTH. Of the 114 patients that did not present with an active PTH, only 1 returned to the operating theatre due to later bleeding. Almost half (43%) of the patients with multiple episodes of PTH had also experienced primary bleedings. Conclusions: A primary PTH seems to indicate a risk of further episodes of bleedings, and should necessitate extra post-operative observation. Patients with a history of a single self-limiting PTH showed low risk of developing a haemorrhage requiring return to the theatre.
Hemostatic Factors and Subclinical Brain Infarction in a Community-Based Sample: The ARIC Study
Authors: Gottesman R.F. , Cummiskey C. , Chambless L. , Wu K.K. , Aleksic N. , Folsom A.R. , Sharrett A.R.
Published: October 2009

Background: Previous data are conflicting as to whether imbalance between hemostatic factors is associated with clinical strokes. We evaluated the association between hemostatic factor levels and subclinical lacunar infarcts in a nested sample from a subset of the Atherosclerosis Risk in Communities (ARIC) cohort. Methods: 196 cases without clinical strokes had lacunar infarcts by MRI, and 214 controls without radiographic infarcts were frequency-matched by age group and sex. Logistic regression models were fitted to assess the association between levels of hemostatic markers and case status. Results: In age-, race- and sex-adjusted models, von Willebrand factor (vWF) and D-dimer were positively associated with case status, with odds ratios for the highest vs. lowest tertile of 2.0 (95% CI 1.2–3.6) for vWF and 1.76 (95% CI 1.02–3.0) for D-dimer. Plasminogen had nonsignificant inverse associations with presence of silent lacunar infarcts. Conclusions: vWF and D-dimer were positively associated, and plasminogen was nonsignificantly inversely associated with subclinical radiographic infarct. Further studies on the role of these hemostatic factors in the development of silent lacunar infarcts may help elucidate the mechanisms behind this injury and may even point to potential targets for future intervention.
Cogan’s Syndrome
Authors: Ochonisky S. , Chosidow O. , Kuentz M. , Man N. , Fraitag S. , Pelisse J.M. , Revuz J.
Published: October 2009

We report the case of an 18-year-old black woman with urticarial vasculitis, vestibuloauditory dysfunction and superficial keratitis. Oral steroid therapy was effective in reducing most clinical manifestations with high-dosage dependency. However, only intravenous pulses of methylprednisolone allowed slight improvement of hearing. In this case we emphasize urticarial vasculitis as a new manifestation of atypical Cogan’s syndrome. A significant titer of Chlamydia trachomatis antibodies was found in our patient: their role in the pathogenesis of Cogan’s syndrome is discussed.
Eccrine Syringofibroadenomatous Hyperplasia in a Patient with Bullous Pemphigoid: A Case Report and Review of the Literature
Authors: Nomura K. , Kogawa T. , Hashimoto I. , Katabira Y.
Published: October 2009

A 76-year-old man with multiple erythematous lesions on his palms and soles which appeared following bullous pemphigoid (BP) is the subject of this case report. The lesions were not raised above the normal skin level, and there were no nodules on the erythematous lesions. The lesions had the histologic appearance of eccrine syringofibroadenoma. This condition is considered to be not a true tumor but a hyperplasia of eccrine sweat ducts following recurrent subepidermal blister formation in BP.
Sebaceous Trichofolliculoma on Scrotum and Penis
Authors: Nomura Masao , Hata Seiichirou
Published: October 2009

A case of unique sebaceous trichofolliculoma on scrotum and penis is reported. Until now, this tumor has been reported as a solitary tumor only on the nose. The patient showed many small soft nodules for several years, then they became large while some of them amassed. Histological examination showed many cystic cavities with many sebaceous follicles connected to them. No cell atypia or recurrence after excision was noted. A diagnosis of sebaceous trichofolliculoma was made based on histological findings.
Bilateral Squamous Cell Carcinomas Arising in Long-Standing Necrobiosis lipoidica
Authors: Beljaards Rob C. , Groen Jan , Starink Theo M.
Published: October 2009

We describe the second case of bilateral squamous cell carcinoma arising in long-standing necrobiosis lipoidica. The occurrence of squamous cell carcinoma in necrobiosis lipoidica is rare but should be considered in recalcitrant ulcers, especially when infiltrated.
Clinical Distribution of Anticentromere Antibody in Japanese Patients
Authors: Soma Y. , Takehara K. , Ishibashi Y.
Published: October 2009

Serum samples from 401 subjects were screened for the presence of anticentromere antibody using HEp-2 cells as the substrate for an indirect immunofluorescence method. Anticentromere antibody was found in 16 cases; 8 out of 62 patients with systemic sclerosis, 3 out of 7 patients with primary Raynaud’s disease, 2 out of 41 patients with systemic lupus erythematosus, 1 out of 54 asymptomatic relatives of systemic sclerosis and 2 out of 50 patients with miscellaneous diseases. In systemic sclerosis, the patients with anticentromere antibody were limited in CREST (calcinosis, Raynaud’s phenomenon, esophageal involvement, sclerodactylia and telangiectasia) variant. As reported previously by many investigators, anticentromere antibody is considered as a useful immunologic marker for CREST variant of systemic sclerosis, although this antibody is widely distributed in other conditions with less frequency.
Polymorphic Pemphigoid
Authors: Bernard Philippe
Published: October 2009

The term polymorphic pemphigoid has been used in the literature as a variant of bullous pemphigoid. But this term is imprecise and now obsolete, since patients with linear IgA dermatosis have been reported under this terminology. The patients who develop an atypical subepidermal bullous disease with clinical and histological features of both bullous pemphigoid and dermatitis herpetiformis may actually be classified into three groups: (1) vesicular variant of bullous pemphigoid; (2) linear IgA dermatosis, and (3) mixed subepidermal bullous disease.
Localized Argyria Caused by Silver Earrings
Authors: van den Nieuwenhuijsen Ingrid J. , Calame Jan J. , Bruynzeel Derk P.
Published: October 2009

A patient with silver earring backings, embedded in the ear lobes for several years, developed blue macules of localized argyria on both sides.
Autosomal Dominant Keratoderma, Ichthyosiform Dermatosis and Elevated Serum Beta-Glucuronidase
Authors: Camisa Charles , Hessel Adam , Rossana Cindy , Parks Alan
Published: October 2009

Five patients in a large pedigree with autosomal dominant palmoplantar keratoderma and/or an ichthyosiform dermatosis were studied. Biopsies of the keratoderma, a remote hyperkeratotic plaque on an arm and the ichthyosis all revealed the same histopathologic changes including hyperkeratosis with round retained nuclei. All 5 patients had elevated serum beta-glucuronidase activity. The significance of beta-glucuronidase in this and other skin diseases is discussed.
Photosensitive Psoriasis Provoked by a Suberythematous Dose of Ultraviolet-B Light
Authors: Kudoh Kazuhiro , Obata Masaaki , Torinuki Wakio , Tagami Hachiro
Published: October 2009

An unusual case of ‘photosensitive psoriasis’ is reported. This patient had experienced an exacerbation after sea-bathing, and psoriatic eruptions were observed on the sun-exposed areas of the body. Phototesting with ultraviolet-B (UV-B) revealed his minimal erythema dose to be within normal limits. Three to four weeks after phototesting, however, he developed a psoriatic macule on the area exposed to the suberythematous dose of UV-B. The histologic features of the skin lesion provoked by UV-B irradiation were similar to those of naturally occurring lesions on areas covered by clothes. Moreover, failure to reproduce skin lesions following tape-stripping ruled out a proneness of this patient to develop the Köbner phenomenon nonspecifically.
Anogenital Warts of the Condyloma acuminatum Type in HIV-Positive Patients
Authors: Rüdlinger R. , Grob R. , Buchmann P. , Christen D. , Steiner R.
Published: October 2009

Anogenital warts of the condyloma acuminatum type seem to occur quite often during HIV infection. These warts – according to our study – are not commonly caused by malignancy-associated human papilloma virus types, but by types 6 and 11 as seen in the nonimmune-compromised population. Widespread condylomata acuminata may appear in rather early stages of HIV infection and they may therefore represent early warning signs of HIV infection.
Long-Term Efficacy and Side Effects of Tap Water Iontophoresis of Palmoplantar Hyperhidrosis – the Usefulness of Home Therapy
Authors: Hölzle E. , Alberti N.
Published: October 2009

Treatment of palmoplantar hyperhidrosis was carried out with a conventional galvanic generator in 40 patients and with a newly developed iontophoresis apparatus, which is suited for home treatment, in 31 patients. The new apparatus is operated by a rechargeable energy source or by batteries and is disconnected from the electrical net during treatment. It conforms to most recent safety regulations as approved by Underwriter’s Laboratory. Hyperhidrosis was completely controlled after 10–12 treatments as revealed by quantitative gravimetric measurements of sweat rates and semiquantitative estimation of starch iodine paper imprints. There was no apparent difference in efficacy between the two apparatuses. Not only hyperhidrosis was abolished, but associated symptoms, such as lividity of palms or soles, acral hypothermia and edema of fingers or toes, also subsided. Skin temperature on palms rose from 29.7 ± 1.8 °C before treatment to 32.2 ± 1.4 °C thereafter. Maintenance treatment was continued on an average for 14 months, in 4 patients for more than 3 years. No loss of efficacy was found during that period. Side effects were minimal and depended upon amperage used. Only slight discomfort during treatment and mild short-lasted skin irritation were observed. Long-term side effects did not occur.
Glucose Tolerance Studies in Lichen planus
Authors: Nigam P.K. , Sharma Lata , Agrawal J.K. , Singh Gurmohan , Khurana S.K.
Published: October 2009

A study of glucose tolerance and insulin response to oral glucose was carried out in 56 consecutive histologically confirmed cases of lichen planus. 30.3% patients showed abnormal glucose tolerance. The pattern of insulin response was similar to that seen in type II diabetes. Insulin/glucose ratio showed the same relationship as seen in type II diabetes. These results reinforce the possibility of glucose intolerance in lichen planus patients. However, no correlation between glucose tolerance abnormalities and duration and distribution of lesions was observed.
Expression of c-Myc, c-Myb, c-Erb-B and c-H-Ras Oncogene mRNAs in Fibroblasts Cultured from Psoriatic Patients
Authors: Basset N. , Vie A. , Blanchard J.M. , Guilhou J.J.
Published: October 2009

The abnormally high rate of proliferation described in cultured psoriatic fibroblasts could result from inappropriate expression of cellular oncogenes (c-onc) associated to the control of cell division. Four c-onc (c-Myc, c-Myb, c-Erb-B, c-H-Ras) were studied in cultured fibroblasts from lesional and nonlesional psoriatic skin (n = 6) and compared with normal subjects (n = 3). RNA was analyzed by hybridization with nick-translated cloned human DNA probes after extraction by the guanidinium thiocyanate/LiCl procedure, electrophoresis and transfer on nitrocellulose. No difference in the level of c-Myc and c-Myb mRNA could be detected in psoriatic skin compared with controls. N-Ras did not give a detectable signal and c-Erb-B exhibited individual variations which were not linked to the disease. These results do not rule out subtle qualitative changes of these genes; moreover, an abnormal mRNA expression of other c-onc remains possible in psoriasis.
Multistep Process of Squamous Differentiation of Tracheobronchial Epithelial Cells: Role of Retinoids
Authors: Jetten Anton M.
Published: October 2009

The objective of our research is to elucidate the molecular mechanisms that regulate the proliferation and differentiation of tracheobronchial epithelial cells. A clear insight into the basic mechanisms of these processes is required in order to understand the mechanisms involved in tumor development and other pathological conditions. To study the regulation of differentiation of the tracheobronchial epithelium, an in vitro cell culture model was developed using rabbit tracheal epithelial cells. Our studies were directed towards answering the following questions: (1) What is the differentiation capacity of these cells? (2) Does differentiation occur as a multistep process? (3) What factors control differentiation and by what mechanism? (4) What are the biochemical markers for the various differentiated phenotypes and at what level are they controlled? (5) Is there a link between control of cell growth and control of cell differentiation?
Topical Minoxidil for Androgenetic Alopecia: Optimizing the Chance for Success by Appropriate Patient Selection
Authors: DeVillez R.L.
Published: October 2009

Cosmetically acceptable hair growth was achieved in 18 (32%) of 56 balding male subjects during a 12-month study using 2 or 3% topical minoxidil. The criteria for successful hair regrowth devised from those subjects were: (1) no baldness greater than a Hamilton pattern IV; (2) a balding vertex area smaller than 10 cm in diameter, and (3) a balding process of less than 5 years’ duration. Frontotemporal hair loss did not respond to treatment and in fact progressed in severity, despite the twice-daily applications of minoxidil. In a subsequent study of 91 subjects who met these three criteria, 51 (56%) subjects achieved cosmetically acceptable hair growth after 1 year using 2% topical minoxidil (Regaine®; registered trade mark of The Upjohn Company) twice daily.
Importance of the Dermal-Epidermal Junction and Recent Advances
Authors: Woodley David T.
Published: October 2009

The zone of human skin between the epidermis and dermis is called the dermal-epidermal junction (DEJ). The importance of the DEJ is outlined and three new areas of research involving the DEJ are reviewed: the intracellular pool of bullous pemphigoid antigen, the interactions between fibronectin and keratinocytes and the epidermolysis bullosa acquisita antigen.
Tunable Pulsed Dye Laser for the Treatment of Benign Cutaneous Vascular Ectasia
Authors: Polla Luigi L. , Tan Oon T. , Garden Jerome M. , Parrish John A.
Published: October 2009

A tunable pulsed dye laser emitting at 577 nm and 360 μs pulse width was used to treat benign cutaneous vascular ectasias other than port wine stain in 77 patients. Except for leg telangiectasias (34 patients), the overall response was excellent. Forty-two of forty-five patients with hemangiomas, spider nevi, angioma serpiginosum, venous lakes or facial telangiectasias showed excellent results after 1–4 consecutive treatments. Scarring was observed in none of the patients. These results confirm previous data on the use of the tunable dye laser in the treatment of port wine stain, and suggest that 577 nm wavelength and 360 μs pulse width allow the selective photothermolysis of vascular cutaneous ectasias with better clinical results than previously reported.
A Case of Secondary Syphilis with a Solitary Pulmonary Lesion
Authors: Kurumaji Yuko , Katoh Takuro , Ohtaki Noriko , Tachibana Shun-ichi , Hashimoto Ken-ichi
Published: October 2009

This study describes a case of secondary syphilis with a papular eruption and penile ulceration. A chest roentgenogram showed a solitary lesion in the left middle lung field. Histological examination revealed epithelioid cell granuloma in both the penile ulcer and the lung lesion. After antisyphilitic treatment, the lung lesion shrunk remarkably and at the same time the skin eruption and the systemic symptoms also improved.
Evaluation of Adrenomedullary Function in Patients with Congenital Adrenal Hyperplasia
Authors: Tutunculer Filiz , Saka Nurcin , Arkaya Selda Can , Abbasoglu Semra , Bas Firdevs
Published: October 2009

Background/Aims: Congenital adrenal hyperplasia (CAH) is characterized by adrenal insufficiency with or without salt wasting. It is also accompanied by adrenomedullary hypofunction. The aim of the present study was to investigate adrenomedullary function in patients with CAH due to 21-hydroxylase and 11β-hydroxylase deficiencies and in age-matched normal subjects. Methods: We measured plasma catecholamines (epinephrine and norepinephrine) and urine metanephrine in 44 patients with CAH, 32 due to 21-hydroxylase deficiency (17 patients with the salt-wasting form and 15 patients with the simple virilizing form), and 12 due to 11β-hydroxylase deficiency, and in 25 healthy controls. Results: Plasma epinephrine and urine metanephrine levels were significantly higher in the controls than in patients with CAH (p = 0.02 and p < 0.001, respectively). Plasma norepinephrine levels were significantly lower in the controls than in patients with CAH (p < 0.001). Interestingly, patients with the salt-wasting form had lower norepinephrine levels in comparison to the other subgroups of CAH. Conclusion: Despite the fact that CAH patients have insufficient epinephrine secretion, these patients have the ability to increase compensatory norepinephrine. However, this increase is much lower in patients with the salt-wasting form. These findings need to be confirmed by other studies.
Seven Years of Safety and Efficacy of the Recombinant Human Growth Hormone Omnitrope® in the Treatment of Growth Hormone Deficient Children: Results of a Phase III Study
Authors: Romer T. , Saenger P. , Peter F. , Walczak M. , Le Bouc Y. , Khan-Boluki J. , Berghout A.
Published: October 2009

Aim: This phase III clinical study in growth hormone deficiency (GHD) children with growth retardation was designed to compare efficacy and safety of Omnitrope® with Genotropin® and assess the long-term safety and efficacy of Omnitrope®. The results of 7 years of treatment with Omnitrope® are presented. Patients and Methods: Eighty-nine treatment-naïve, prepubertal children with GHD were randomized (part 1) to Omnitrope® lyophilisate (group A, n = 44) or Genotropin® (group B, n = 45) for 9 months and received a subcutaneous dose of 0.03 mg/kg/day. In part 2, patients receiving Omnitrope® lyophilisate continued the same treatment for a further 6 months, while patients on Genotropin® were switched to Omnitrope® liquid for the subsequent 6 months. In part 3, patients in both groups received Omnitrope®liquid for a period up to 69 months. Results: The development of the 4 auxological parameters (height, height SD score, height velocity and height velocity SD score) and IGF-1 and IGFBP-3 levels were comparable between both groups of patients and confirmed the well-known growth response of GHD children to recombinant human GH treatment. Omnitrope® was well tolerated and safe over 7 years of treatment. Conclusion: The clinical comparability between Omnitrope® and Genotropin® was demonstrated within 9 months of treatment. Long-term safety and efficacy of 7 years of treatment with Omnitrope® was proven.
Fibroblasts of an Acrogeria Patient Produce Normal Amounts of Type I and III Collagen
Authors: Bruckner-Tuderman L. , Vogel A. , Schnyder U.W.
Published: October 2009

An 11-year-old patient with clinically typical acrogeria is presented. She had wrinkled ‘old-appearing’ acral skin, thin skin on the whole integument, grooved tip of nose, mottled hyperpigmentation of fold regions and thickened dystrophic toe nails. Histologically, the epidermis was flattened, dermis thinned and the connective tissue densely packed with very few cellular elements. Electron microscopic examination revealed partially abnormal collagen fibers with varying caliber, degenerated elastic fibers and dystrophic fibroblasts. The patient’s fibroblasts produced normal amounts of apparently normal type I and III collagen as analyzed after radioactive labeling. Also, the levels of cytoplasmic mRNA for both of these collagens were similar in acrogeria and control cells.
Significant Increase of Urinary Low-Sulfated Heparan-Sulfate-Related Protein in Patients with Severe Systemic Scleroderma
Authors: Kitabatake M. , Ishikawa H. , Uchiyama Y.
Published: October 2009

Radioimmunoassay with an antibody produced against urinary low-sulfated heparan-sulfate-related protein was devised and used to screen the heparan sulfate level in the urine of patients with systemic scleroderma. Patients with diffuse scleroderma, and patients also showing polymyositis/dermatomyositis had elevated values, whereas the value in patients with acrosclerotic scleroderma did not differ from that of the control population. In addition, an increase in this protein was associated with the positivity of anti-Scl-70 antibody. These findings suggest an important role for low-sulfated heparan sulfate in the pathobiology of severe systemic scleroderma.
Exfoliative Dermatitis
Authors: Sehgal V.N. , Srivastava G.
Published: October 2009

A prospective study in 80 exfoliative dermatitis patients over a period of 5 years establishes 41.9 years as its mean age at onset. The disease affected both males and females, with a preponderance of the former. The clinical features were identical, irrespective of the etiology. The onset of the disease was usually insidious except in staphylococcal scalled skin syndrome and drug-induced erythroderma, where it was abrupt and florid. Microcytic hypochromic anemia, elevated erythrocyte sedimentation rate, eosinophilia, low serum proteins and electrolytes were salient laboratory features. Histopathology was largely unrewarding; only in 12 patients, a good clinicohistologic correlation was present. Preexisting dermatoses, namely psoriasis, air-borne contact dermatitis, phytophotodermatitis, photosensitive and seborrheic dermatitis, and other dermatoses constituted the major etiology. Antituberculous drugs were responsible for a substantial proportion of drug-induced erythroderma. No lymphomas were found. This study outlines that some salient features of exfoliative dermatitis may show geographic variations.
Necrobiosis lipoidica: Clinical and Immunofluorescent Study
Authors: Laukkanen Arja , Fräki Jorma E. , Väätäinen Niilo , Korhonen Timo , Naukkarinen Anita
Published: October 2009

Fourteen patients with necrobiosis lipoidica (NL) were carefully evaluated clinically and histologically. Ten of these patients (71%) had diabetes and most of them were treated with insulin (8 of 10 patients). Trauma was found as an immediate triggering factor in 6 patients (43%) and a possible preceding factor in 3 more cases. No immunoglobulins were found in the lesional skin of NL. Intradermal injections of histamine in healthy skin of legs led to deposition of immunoglobulins and complement (C3) in skin blood vessel walls in 4 of 12 patients studied (30%). These results suggest that immune complexes might be involved only in few cases of NL. Preceding trauma combined with metabolic and inflammatory changes could be an important triggering factor in the etiology of NL.
Delayed Flare-up Reactions Caused by Jellyfish
Authors: Ohtaki Noriko , Satoh Akihiko , Azuma Hiroshi , Nakajima Terumi
Published: October 2009

Four patients had a reccurrence of cutaneous lesions 1 week after being stung by jellyfish. Three patients had flare-up lesions after only one exposure to jellyfish. All of the recurring lesions were vesicular erythema, and the histological findings of case 3 corresponded to that of allergic contact dermatitis.
‘Mondor’s phlebitis’ – A Lymphovascular Process
Authors: Marsch Wolfgang C. , Haas Norbert , Stüttgen Günter
Published: October 2009

Histological details of 2 cases of ‘Mondor’s phlebitis’ suggest that we are dealing with a process affecting lymphatic vessels. Fibrin thrombus formation with myocytic organization and capillary recanalization as well as fíbromuscular hyperplasia of the vessel wall with infiltration of the surrounding fatty tissue determine the pathogenesis of the disease. ‘Lymphangiofibrosis thrombotica occlusiva’ is a more appropriate term.
Assessment of Epidermal Atrophy in Localized Scleroderma (Morphea)
Authors: Serup Jørgen
Published: October 2009

The skin surface of scleroderma skin becomes glossy as a result of epidermal atrophy. In this study, the skin relief was studied in 12 patients with localized scleroderma (morphea). Measurements by a stylus method showed smoothening of the skin in all plaques studied (p < 0.01). Ultrasound measurement showed increased skin thickness (p < 0.01). There was no correlation between smoothening of the skin surface and increase in skin thickness, and no correlation to the duration of the plaques. It is concluded that glossy appearance of plaques of scleroderma is an early sign, which may be useful in the clinical diagnosis of scleroderma.
In vitro Induction of T-Suppressor Lymphocytes by THF, a Thymic Hormone, in Psoriatic Children
Authors: Shohat Batya , Ideses Carlos , David Michael , Feuerman Eleazar J. , Trainin Nathan
Published: October 2009

T-lymphocyte number and function as well as the effect of a thymic hormone on the T-suppressor cell subset were studied in 22 children suffering from psoriasis vulgaris, subdivided into two groups, those with less than 20% of total skin area involved and those with more than 20% of involvement. The T-cell number was lower in the latter group than it was in the first group or in normal controls. There was no significant difference in the functional activity of T cells in the two groups of patients. The number of T-suppressor cells was significantly lower in the psoriatic children than in normal controls, being lowest in the children showing greater skin involvement. THF, a thymic hormone isolated from calves, was found in vitro to induce T-suppressor cells in the peripheral blood of the psoriatic children, suggesting that this hormone may be able to play a role in the treatment of this disease.
The Dermal Cellular Infiltrate and Cell-Mediated Immunity in Skin Carcinomas
Authors: Avgerinou G. , Nicolis G. , Vareltzidis A. , Stratigos J.
Published: October 2009

The cell-mediated immunity in nonmelanotic skin cancer was studied in 115 patients. The diagnosis and type of skin cancer was histologically evaluated. The T cell levels and leukocyte migration test in preoperative patients with squamous cell skin carcinoma (SCSC) and metatypical basal cell epithelioma were significantly lower than in the noncancer control population. The immunocompetence was not impaired in patients with basal cell epithelioma (BCE) and even in those with BCE that showed deep invasiveness and paucity of lymphocytic infiltration. There was a direct correlation between cell-mediated immunity and the lymphocytic infiltration and differentiation of the cells in SCSC.
Pagetoid Reticulosis (Woringer-Kolopp Disease): Histiocyte Marker (Lysozyme) Study and Ultrastructural Observations
Authors: Natarajan S. , Wilson P.D.
Published: October 2009

A case of pagetoid reticulosis is presented. Histopathology showed infiltration of the epidermis by mononuclear cells. Twenty percent of the mononuclear cells showed the presence of lysozyme indicating a histiocytic origin. Electron microscopy confirmed the presence of lymphocytes and histiocytes but these cells were outnumbered by Sézary cells. The presence of large numbers of Sézary cells indicates that pagetoid reticulosis is a cutaneous T-cell lymphoma closely related to mycosis fungoides.
Epithelioid Sarcoma
Authors: Muscianese V. , Simoni R. , Cavalieri R. , Muscardin L.M.
Published: October 2009

Epithelioid sarcoma is a rare malignant tumor of the soft tissues with particular clinical and anatomicopathological characteristics. Histologically it is characterized by the presence of particular epithelioid cells. After a description of a recently observed case, the authors present a synthesis of the literature on the subject, paying particular attention to the clinical and histological aspects which facilitate an early and correct diagnosis.
Neurofibromatose de Von Recklinghausen et mastocytose systémique
Authors: Mérot Y. , Bauquis C. , Saurat J.-H.
Published: October 2009

We describe a 62-year-old woman who presented with a recurrent neurofibroma, two ‘café-au-lait’ spots and a possible cerebral tumor. This Von Recklinghausen neurofibromatosis was associated with an asymptomatic systemic mastocytosis with bone marrow involvement. We discuss Riccardi’s recent theory on the pathogenesis of neurofibroma which postulates that the mast cells have a primordial role in the development of neurofibroma. Our observation could be additional evidence in favor of this theory.
Evaluation de propriétés mécaniques de la peau par les méthodes d’indentation et de compression
Authors: Piérard G.E.
Published: October 2009

Mechanical properties of skin that are representative of mobility of dermal proteoglycans were determined in vivo. Two techniques are described and compared with each other.
In vitro Susceptibility of Recent Isolates of Neisseria gonorrhoeae to Cephalosporins of Different Generations and Penicillin G: A Comparative Evaluation
Authors: Korting H.C.
Published: October 2009

98 recent clinical isolates of Neisseria gonorrhoeae (96 nonpenicillinase-producing N. gonorrhoeae (NPPNG) and 2 penicillinase-producing N. gonorrhoeae (PPNG) strains) were tested for their antibiotic susceptibility using the agar dilution test. The antibiotics examined all belonged to the β-lactam group: penicillin G represented the penicillins, cephalothin, cefazolin, cefotiam, cefmenoxime and ceftizoxime represented the different groups of cephalosporins. In the in vitro tests cephalothin and cefazolin proved less active than penicillin G, cefotiam a bit more and both cefmenoxime and ceftizoxime much more active. These last three antibiotics should become promising alternatives to penicillin in the therapy of gonorrhea caused either by NPPNG or PPNG strains.
Scabies and Giardiasis
Authors: Falk Edvard S.
Published: October 2009

Serum IgE concentrations and circulating eosinophils were increased in 2 children with scabies and Giardia lamblia infection. Both parameters decreased after scabies elimination, whereas none of them were influenced by the Giardia lamblia infection. This confirms previous observations that scabies stimulates the immune system, whereas Giardia lamblia does not.
Dermatofibromes, élastomes et surdité: un nouveau cas de syndrome de Buschke-Ollendorff?
Authors: Piette-Brion B. , Lowy-Motulsky M. , Ledoux-Corbusier M. , Achten G.
Published: October 2009

The authors propose a new case of Buschke-Ollendorff syndrome: a female patient aged 54 years presents 17 tumoral lesions out of which some are dermatofibromas and other elastomas. Deafness appeared 5 years after the cutaneous lesions and seems to be the result of a pathological condensation of petrous bones.
Pathogenetischer Beitrag zur Akrokeratose Bazex
Authors: Hagedorn M. , Stengel R.
Published: October 2009

A 67-year-old male patient with typical signs of acrokeratosis Bazex is presented. The psoriasiform skin lesions appeared 9 months after diagnosis of an oesophagus neoplasm. Clinically there was a marked hepatopathy but no signs of metastases. Histological, immunofluorescence-histological, and ultrastructural findings revealed a capillaritis with humoral as well as cellular inflammation. With treatment of the neoplasm the paraneoplasia regressed under additional treatment with topical steroids. The vitamin A deficit could not be normalized by oral or parenteral vitamin A substitution. We discuss some mechanisms in formal pathogenesis.
1200 mg Rifampicin (Rimactan®) als Einzeldosisbehandlung der unkomplizierten Gonorrhoe der Frau
Authors: Schwarzenbach H.R. , Rufli Th. , Glaus L. , Bergamini N.
Published: October 2009

40 women were treated for uncomplicated genital gonorrhoea, verified by culture, with a single oral dose of 1,200 mg rifampicin (Rimactan®). The ages ranged between 15 and 51 years. In 33 patients that could be evaluated, the gonorrhoea was cured. In 8 of 18 patients the preexistent vaginal discharge improved. 4 women experienced six different side effects which were probably or possibly related to rifampicin. The 1,200-mg rifampicin oral one-dose treatment is a reliable, efficient, and well-tolerated therapy of uncomplicated gonorrhoea in women.
Perineal Cloacogenic Cyst
Authors: Anani P. , Leu F. , Delacrétaz J.
Published: October 2009

A 25-year-old man presents since birth a pedunculated lesion, showing histologically a cyst the lumen of which is lined by a transitional epithelium.
Essai d’une nouvelle méthode sérologique pour la détection de la syphilis active
Authors: Brun R.
Published: October 2009

We examined sera of syphilitic patients by solid-phase hemadsorption which provides specific anti-treponemic IgM titers. The results are encouraging and show that this method will probably be useful to monitor the treatment of syphilitic patients.
Mycosis fongoïde de localisation inhabituelle; guérison par radiothérapie
Authors: Fierens F. , Bourlond A. , Guilmot-Bruneau M.M. , Saussez-De Temmerman A.
Published: October 2009

A patient presented with only one tumor of mycosis fungoides and remained free of any lesion 5 years after conventional radiotherapy.
Transfer Factor in Atopic Dermatitis
Authors: Cramers Marie , Jensen Jørgen R. , Kragballe Knud , Herlin Troels , Zachariae Hugh , Thestrup-Pedersen Kristian
Published: October 2009

Dialyzable leukocyte extract (transfer factor, TF) from unselected healthy blood donors was given every other week during 1 year to adult patients with severe atopic dermatitis. The results from this double-blind investigation did not reveal any clinical benefit of TF therapy. Nor did we find evidence for a change in prick tests, RAST, delayed type skin reactivity towards tuberculin and Candida albicans extract, change in IgE levels in serum, distribution of T or B lymphocytes, mitogen reactivity in vitro or monocyte cytotoxicity.
Lupus vulgaris of the Oral Mucosa
Authors: Laskaris George C. , Nicolis George D.
Published: October 2009

4 cases of lupus vulgaris of the oral mucosa were found to be associated with asymptomatic pulmonary tuberculosis. The patients presented with single or multiple ulcerations of the mouth with an irregular periphery and a granular vegetative fundus. The diagnosis was established histologically and by the favorable and rapid response of the oral lesions to the antituberculosis therapy.
Pseudo-angiosarcomatose de Kaposi sur membre paralytique
Authors: Meynadier Jean , Malbos Simone , Guilhou Jean-Jacques , Barneon G.
Published: October 2009

4 cases of acroangiodermatitis developing on paralytic feet are reported. Acroangiodermatitis might be an entity different from Mali’s syndrome and Stewart-Bluefarb’s syndrome. Paralysis could generate the dermatologic lesions by increasing venous stasis and enhancing arteriovenous channels.
Beta-Carotene in Erythropoietic Protoporphyria: 5 Years’ Experience
Authors: Thomsen Kristian , Schmidt Henning , Fischer Annelise
Published: October 2009

36 patients from 19 families with erythropoietic protoporphyria were treated for about 5 years during the summer months with beta-carotene alone or beta-carotene plus canthaxanthin in daily doses of 50–200 mg. The effect of the treatment was evaluated clinically on the basis of information provided by the patients regarding the period of time they could stay in the sun. 18 patients became completely free of symptoms, 16 patients improved to some extent, and 2 patients noted a slight effect. Apart from the carotenaemia, no side-effects were recorded.
Nevus unius lateralis Exhibiting Intraepidermal Basaloid Cell Formation Simulating Superficial Basal Cell Epithelioma
Authors: Bedi T.R.
Published: October 2009

A unilateral verrucous lesion with clinical characteristics of nevus unius lateralis (NUL) in an 18-year-old boy, showed histopathological features of intraepidermal basaloid cell formations simulating superficial basal cell epitheliomas. Biological significance of this phenomenon is discussed. The lesion is considered a most peculiar variant of NUL.
Scleroderma-Inducing Glycosaminoglycan in the Urine of Patients with Systemic Scleroderma
Authors: Ishikawa H. , Saito Y. , Yamakage A. , Kitabatake M.
Published: October 2009

A glycosaminoglycan with scleroderma-inducing effect was isolated and partially purified from the urine of patients with systemic scleroderma. The glycosaminoglycan was an N-sulfated glycosaminoglycuronan and its high total sulfate and 2,5-anhydromannose contents suggest that the glycosaminoglycan is a degradation product of heparin or polysulfated heparan sulfate. Furthermore, the composition of the above glycosaminoglycan was similar to that of the N-sulfated glycosaminoglycan which we observed previously in uninvolved skin of scleroderma.
HL-A Antigens in Behçet’s Disease
Authors: Nahir M. , Scharf Y. , Gidoni O. , Barzilai A. , Friedman-Birnbaum R. , Haim S.
Published: October 2009

Histocompatibility antigens (HL-A) were studied in a family with Behçet’s disease (BD). All who had symptoms or signs of BD had either HL-A B5 or BW35, or both.
Ultrastructural and Biochemical Studies on a Case of Elastosis perforans serpiginosa
Authors: Volpin D. , Ronchetti Pasquali , Castellani I. , Giro M.G. , Peserico A. , Mori G.
Published: October 2009

Ultrastructural and biochemical studies on the collagen and elastin fibres of the dermis from a patient with Elastosis perforans serpiginosa are described. Qualitative and quantitative alterations on collagen and elastin are shown, which give some evidence for considering the disease as a connective tissue defect.
A Multicentered Study of Lysine Therapy in Herpes simplex Infection
Authors: Griffith Richard S. , Norins Arthur L. , Kagan Christopher
Published: October 2009

Lysine appears to suppress the clinical manifestations of herpesvirus infection. 45 patients with frequently recurring herpes infection were given 312–1,200 mg of lysine daily in single or multiple doses. The clinical results demonstrated a beneficial effect from supplementary lysine in accelerating recovery from herpes simplex infection and suppressing recurrence. Tissue culture studies have demonstrated an enhancing effect on viral replication when the amino acid ratio of arginine to lysine favors arginine. The opposite, preponderance of lysine to arginine, suppresses viral replication and inhibits cyto-pathogenicity of herpes simplex virus. The codons characterizing herpes simplex DNA apparently specify production of viral capsids at the expense of host cell histones.
Total Skin Electron Irradiation in Mycosis fungoides
Authors: van Vloten W. , Vermeij J. , de Vroome H.
Published: October 2009

Total skin irradiation with fast electrons (4 MeV, 3,500 rad) was applied in 10 cases of histologically proven mycosis fungoides without any signs of internal dissemination. The technique is described. Complete disappearance of both lesions and symptoms occurred in all patients after treatment. However, half of the patients relapsed after the initial irradiation and were subsequently treated with a booster dose of 1,000 rad 4 MeV electrons or with topical nitrogen mustard. Irradiation with fast electrons seems to be of great importance in the treatment of mycosis fungoides.
Treatment of Acne vulgaris with Cyproterone Acetate and Ethinyl Estradiol
Authors: van Velde J.L.
Published: October 2009

The results obtained with low-dosage treatment with 2 mg cyproterone acetate and 0.05 mg ethinyl estradiol in 10 women with moderate to severe acne are reported. Eight of these patients showed a very good response, one a moderate response, and one showed no improvement after 3 months. In four patients the administration of antibiotics could be discontinued, and in most of the other patients the dose could be reduced. Three patients discontinued this treatment, two because of side effects and one because of lack of improvement.
Photochemotherapy in Treatment of Psoriatic Variants
Authors: Vukas A.
Published: October 2009

Our procedure for treating psoriatic variants – psoriasis pustulosa generalisata (PPG) and psoriasis erythrodermica (PE) – was based on the following points: (a) to quickly obtain a good tolerance level to photochemotherapy (PUVA) by applying corticosteroids and/or methotrexate (MX); (b) to discontinue the application of systemic drugs with the help of photochemotherapy, and (c) to maintain the improved condition by applying radiation in gradually prolonged intervals, thus enabling the biologic forces of the organism to participate, undisturbed by drugs, in the healing process. In some PE cases, sole PUVA therapy was sufficient, while in others small doses of MX were added to maintain the improved condition. In PPG, skin manifestations completely disappeared and general symptoms were calmed in the first application of this combined therapeutic procedure. However, in the later relapses PUVA had little share in such a combined treatment.
A Double-Blind Study Comparing Daktacort®, Miconazole and Hydrocortisone in Inflammatory Skin Infections
Authors: Mertens R.L.J. , Morias J.M. , Verhamme G.
Published: October 2009

In a 4-week double-blind trial, Daktacort® cream was compared with each of its constituents (i.e. miconazole 2% and hydrocortisone 1%) in a total of 63 patients (aged 12–60 years) with inflamed skin infections of bacterial or mycotic origin. Daktacort treatment induced a significant improvement of all symptoms within 1 week and was superior to both miconazole and hydrocortisone in suppressing the inflammation. This tendency persisted throughout the trial but at the end miconazole treatment proved also superior to hydrocortisone.
Zur Wirkung von 8-Methoxypsoralen (8-MOP) und Blacklight auf Mikroorganismen in vitro und den Ablauf der experimentellen Meerschweinchen-Trichophytie
Authors: Oberste-Lehn H. , Plempel M.
Published: October 2009

The lack of experimental test models causes problems in comparative evaluations of photodynamic effects of 8-MOP and its possible derivatives after irradiation with blacklight or other irradiation sources. In our experiments in vitro, tests with various microorganisms and the in vivo model of experimental dermatophytosis in guinea pigs by Trichophyton mentagrophytes appeared to be suitable. In vivo, 8-MOP was applicated orally and topically in two formulations.
The Retinoic Acid Derivative Ro 11-1430 in Acne vulgaris
Authors: Christiansen Jørgen , Holm Per , Reymann Flemming
Published: October 2009

In a double-blind controlled multicenter trial consisting of 257 patients with acne vulgaris an 8-week topical treatment with the retinoic acid derivative Ro 11-1430 (0.1% lotion) was compared with vitamin A acid (0.05% lotion) and the lotion alone (placebo). In reducing the number of comedones vitamin A acid was superior to Ro 11-1430, which was significantly better than placebo. The reduction in number of papules and pustules was not statistically significant on either treatment. Local side effects, i.e. erythema, desquamation, burning and pruritus occurred more frequently and were more severe on vitamin A acid than on Ro 11-1430 and placebo which did not differ. No correlation was found between incidence and severity of local reactions and therapeutic effect.
Primary Eruption of Prurigo simplex subacuta
Authors: Uehara Masami , Ofuji Shigeo
Published: October 2009

28 patients with typical picture of prurigo simplex subacuta were examined for the primary eruption. In all patients, the first visible lesion was a papule, at the top of which a vesicular element was never seen. 46 biopsy specimens of the initial eruption were serially sectioned. The histological changes were found in connection with hair follicles, which consisted of spongiosis and mononuclear cell migration at the follicular epidermis and perifollicular infiltrates of mononuclear cells.
An Evaluation of Betamethasone Dipropionate (Diprosone) versus Locacorten 0.02% Cream
Authors: Mali J.W.H.
Published: October 2009

A double-blind randomized evaluation of betamethasone dipropionate cream (Diprosone) compared with Locacorten 0.02% cream flumethason pivalate in 60 patients over 3 consecutive weeks showed the betamethasone dipropionate cream to be significantly more effective in the treatment of psoriasis and other steroid-responsive dermatoses
Lymphangioma circumscriptum of the Tongue
Authors: Brandrup Flemming
Published: October 2009

A case is reported of severe transient macroglossia after biopsy from the tongue in a 13-year-old boy who has had intermittent macroglossia since the age of 1 year as a result of extensive lymphangioma circumscriptum of the tongue. The acute lesions appear to result from haemorrhage into the lymphatic spaces following rupture of blood vessels in connective tissue septa and possibly secondary infection.
Atypical Sweat Duct Hyperplasia Accompanying Keratoacanthoma
Authors: Cruz Daniel J. Santa , Clausen Kathryn
Published: October 2009

25 cases of atypical sweat duct proliferation in association with cutaneous tumors are described. 20 of these were keratoacanthomas. The compression of the duct either in its dermal or intraepidermal portion is considered to be the etiology. Similar changes are seen with decubitus ulcer and stasis dermatitis. Atypical sweat duct hyperplasia may be useful as an extra aid in the differentiation of keratoacanthoma from well-differentiated squamous cell carcinoma.
A Bacteriological Study on Children with Staphylococcal Toxic Epidermal Necrolysis in Japan
Authors: Sarai Yasunaga , Nakahara Hideomi , Ishikawa Tomoaki , Kondo Isamu , Futaki Shohei , Hirayama Kaoru
Published: October 2009

From 1973 to 1976, 21 patients with staphylococcal toxic epidermal necrolysis were admitted to the Jikei University Hospital in Tokyo. Of all of them were isolated coagulase-positive Staphylococcus aureus from various sites. In Japan, unlike in Europe and America, phage group II cocci were found in few cases. On the other hand, S. aureus belonging to other phage groups than group II (I, III mixed group and III group) were very commonly isolated. All the isolates produced exfoliatin which was capable of producing exfoliation in newborn mice. The type (A or B) of exfoliatin which was detected by the antiserum agar method did not correlate to the severity of this disease.
A propos des basophiles dans l’infiltrat de l’eczéma experimental chez le cobaye
Authors: Hunziker N. , Olmos L.
Published: October 2009

We observed, in addition to the lymphocytes of the classical descriptions, large numbers of basophils in the infiltrate of the specific sensitization reaction with dinitrochlorobenzène and citraconic acid, a few eosinophils in the reaction with dinitrochlorobenzène and rather more eosinophils in the reaction with citraconic acid.