bluuebunny/crossref_metadata_2025 huggingface dataset:
The Origin of the Most Energetic Galactic Cosmic Rays: Supernova Explosions into Massive Star Plasma Winds
Authors: Biermann Peter L. , Kronberg Philipp P. , Allen Michael L. , Meli Athina , Seo Eun-Suk
Published: April 2019

We propose that the high energy Cosmic Ray particles up to the upturn commonly called the ankle, from around the spectral turn-down commonly called the knee, mostly come from Blue Supergiant star explosions. At the upturn, i.e., the ankle, Cosmic Rays probably switch to another source class, most likely extragalactic sources. To show this we recently compiled a set of Radio Supernova data where we compute the magnetic field, shock speed and shock radius. This list included both Blue and Red Supergiant star explosions; both data show the same magnetic field strength for these two classes of stars despite very different wind densities and velocities. Using particle acceleration theory at shocks, those numbers can be transformed into characteristic ankle and knee energies. Without adjusting any free parameters both of these observed energies are directly indicated by the supernova data. In the next step in the argument, we use the Supernova Remnant data of the starburst galaxy M82. We apply this analysis to Blue Supergiant star explosions: The shock will race to their outer edge with a magnetic field that is observed to follow over several orders of magnitude B ( r ) × r ∼ c o n s t . , with in fact the same magnetic field strength for such stellar explosions in our Galaxy, and other galaxies including M82. The speed is observed to be ∼0.1 c out to about 10 16 cm radius in the plasma wind. The Supernova shock can run through the entire magnetic plasma wind region at full speed all the way out to the wind-shell, which is of order parsec scale in M82. We compare and identify the Cosmic Ray spectrum in other galaxies, in the starburst galaxy M82 and in our Galaxy with each other; we suggest how Blue Supergiant star explosions can provide the Cosmic Ray particles across the knee and up to the ankle energy range. The data from the ISS-CREAM (Cosmic Ray Energetics and Mass Experiment at the International Space Station) mission will test this cosmic ray concept which is reasonably well grounded in two independent radio supernova data sets. The next step in developing our understanding will be to obtain future more accurate Cosmic Ray data near to the knee, and to use unstable isotopes of Cosmic Ray nuclei at high energy to probe the “piston” driving the explosion. We plan to incorporate these data with the physics of the budding black hole which is probably forming in each of these stars.
Data Acquisition Methodologies Utilizing Ground Penetrating Radar for Cassava (Manihot esculenta Crantz) Root Architecture
Authors: Delgado Alfredo , Novo Alexandre , Hays Dirk B.
Published: April 2019

Cassava (Manihot esculenta Crantz), a root crop utilized as food and industrial starch product, develops and maintains its marketable product sub-surface. Often, however, it is difficult to determine the potentially marketable goods available at any given time due to the sub-surface nature of the product and the inability to non-destructively sample. This dilemma has provided an avenue for application of ground penetrating radar. Relatively available designs of this technology, however, are cumbersome and do not provide the efficiencies for field applications. The objective of this research was to determine the functionality of a two Gigahertz frequency IDS GeoRadar C-Thrue antenna for the detection and parameterization of root architecture to be utilized for estimating marketable product. Cassava roots were buried across three horizontal and two vertical orientations to simulate the multi-directional nature of cassava roots. The antenna has dual polarization which also allowed to testing efficacy of polarization for detecting the varying root orientations. This study found that the C-Thrue system, more specifically, the Vertical transmit and Vertical receive polarization, was the most effective at accurately estimating cassava root length and widths at varying angles that simulate root development in true fields.
European Patent in Immunoncology: From Immunological Principles of Implantation to Cancer Treatment
Authors: Würfel Franziska M. , Winterhalter Christoph , Trenkwalder Peter , Wirtz Ralph M. , Würfel Wolfgang
Published: April 2019

The granted European patent EP 2 561 890 describes a procedure for an immunological treatment of cancer. It is based on the principles of the HLA-supported communication of implantation and pregnancy. These principles ensure that the embryo is not rejected by the mother. In pregnancy, the placenta, more specifically the trophoblast, creates an “interface” between the embryo/fetus and the maternal immune system. Trophoblasts do not express the “original” HLA identification of the embryo/fetus (HLA-A to -DQ), but instead show the non-classical HLA groups E, F, and G. During interaction with specific receptors of NK cells (e.g., killer-immunoglobulin-like receptors (KIR)) and lymphocytes (lymphocyte-immunoglobulin-like receptors (LIL-R)), the non-classical HLA groups inhibit these immunocompetent cells outside pregnancy. However, tumors are known to be able to express these non-classical HLA groups and thus make use of an immuno-communication as in pregnancies. If this occurs, the prognosis usually worsens. This patent describes, in a first step, the profiling of the non-classical HLA groups in primary tumor tissue as well as metastases and recurrent tumors. The second step comprises tailored antibody therapies, which is the subject of this patent. In this review, we analyze the underlying mechanisms and describe the currently known differences between HLA-supported communication of implantation and that of tumors.
Regulation Mechanism of MYC Family Transcription Factors in Jasmonic Acid Signalling Pathway on Taxol Biosynthesis
Authors: Cui Yunpeng , Mao Rongjia , Chen Jing , Guo Zhigang
Published: April 2019

Paclitaxel is an important anticancer drug. The phytohormone jasmonic acid can significantly induce the biosynthesis of paclitaxel in Taxus, but the molecular mechanism has not yet been resolved. To establish the jasmonic acid signalling pathway of Taxus media, based on the gene of the jasmonic acid signalling pathway of Arabidopsis thaliana, sequence analysis was performed to isolate the jasmonic acid signal from the transcriptome, a transcriptional cluster of pathway gene homologs and the full length of 22 genes were obtained by RACE PCR at 5′ and 3′: two EI ubiquitin ligase genes, COI1-1 and COI1-2;7 MYC bHLH type transcription factor (MYC2, MYC3, MYC4, JAM1, JAM2, EGL3, TT8); 12 JAZ genes containing the ZIM domain; and MED25, one of the components of the transcriptional complex. The protein interaction between each were confirmed by yeast two hybridization and bimolecular fluorescence complementation based on similar genes interaction in Arabidopsis. A similar jasmonate signaling pathway was illustrated in T. media. All known paclitaxel biosynthesis genes promoters were isolated by genome walker PCR. To investigate the jasmonate signaling effect on these genes’ expression, the transcription activity of MYC2, MYC3 and MYC4 on these promoters were examined. There are 12, 10 and 11 paclitaxel biosynthesis genes promoters that could be activated by MYC2, MYC3 and MYC4.
Intra-Vitreal Administration of Microvesicles Derived from Human Adipose-Derived Multipotent Stromal Cells Improves Retinal Functionality in Dogs with Retinal Degeneration
Authors: Cislo-Pakuluk Anna , Smieszek Agnieszka , Kucharczyk Natalia , Bedford Peter G.C. , Marycz Krzysztof
Published: April 2019

This study was designed to determine the influence of microvesicles (MVs) derived from multipotent stromal cells isolated from human adipose tissue (hASCs) on retinal functionality in dogs with various types of retinal degeneration. The biological properties of hASC-MVs were first determined using an in vitro model of retinal Muller-like cells (CaMLCs). The in vitro assays included analysis of hASC-MVs influence on cell viability and metabolism. Brain-derived neurotrophic factor (BDNF) expression was also determined. Evaluation of the hASC-MVs was performed under normal and oxidative stress conditions. Preliminary clinical studies were performed on ten dogs with retinal degeneration. The clinical studies included behavioral tests, fundoscopy and electroretinography before and after hASC-MVs intra-vitreal injection. The in vitro study showed that CaMLCs treated with hASC-MVs were characterized by improved viability and mitochondrial potential, both under normal and oxidative stress conditions. Additionally, hASC-MVs under oxidative stress conditions reduced the number of senescence-associated markers, correlating with the increased expression of BDNF. The preliminary clinical study showed that the intra-vitreal administration of hASC-MVs significantly improved the dogs’ general behavior and tracking ability. Furthermore, fundoscopy demonstrated that the retinal blood vessels appeared to be less attenuated, and electroretinography using HMsERG demonstrated an increase in a- and b-wave amplitude after treatment. These results shed promising light on the application of cell-free therapies in veterinary medicine for retinal degenerative disorders treatment.
Systematic Multiomics Analysis of Alterations in C1QBP mRNA Expression and Relevance for Clinical Outcomes in Cancers
Authors: Saha Subbroto , Kim Kyung , Islam S.M. , Cho Ssang-Goo , Gil Minchan
Published: April 2019

C1QBP (Complement Component 1 Q Subcomponent-Binding Protein), a multicompartmental protein, participates in various cellular processes, including mRNA splicing, ribosome biogenesis, protein synthesis in mitochondria, apoptosis, transcriptional regulation, and infection processes of viruses. The correlation of C1QBP expression with patient survival and molecular function of C1QBP in relation to cancer progression has not been comprehensively studied. Therefore, we sought to systematically investigate the expression of C1QBP to evaluate the change of C1QBP expression and the relationship with patient survival and affected pathways in breast, lung, colon, and bladder cancers as well as lymphoma. Relative expression levels of C1QBP were analyzed using the Oncomine, Gene Expression Across Normal and Tumor Tissue (GENT), and The Cancer Genome Atlas (TCGA) databases. Mutations and copy number alterations in C1QBP were also analyzed using cBioPortal, and subsequently, the relationship between C1QBP expression and survival probability of cancer patients was explored using the PrognoScan database and the R2: Kaplan Meier Scanner. Additionally, the relative expression of C1QBP in other cancers, and correlation of C1QBP expression with patient survival were investigated. Gene ontology and pathway analysis of commonly differentially coexpressed genes with C1QBP in breast, lung, colon, and bladder cancers as well as lymphoma revealed the C1QBP-correlated pathways in these cancers. This data-driven study demonstrates the correlation of C1QBP expression with patient survival and identifies possible C1QBP-involved pathways, which may serve as targets of a novel therapeutic modality for various human cancers.
Rational Use of CT-Scan for the Diagnosis of Pneumonia: Comparative Accuracy of Different Strategies
Authors: Garin Nicolas , Marti Christophe , Carballo Sebastian , Darbellay Farhoumand Pauline , Montet Xavier , Roux Xavier , Scheffler Max , Serratrice Christine , Serratrice Jacques , Claessens Yann-Erick , Duval Xavier , Loubet Paul , Stirnemann Jérôme , Prendki Virginie
Published: April 2019

Diagnosing pneumonia in emergency departments is challenging because the accuracy of symptoms, signs and laboratory tests is limited. As a confirmation test, chest X-ray has significant limitations and is outperformed by CT-scan. However, obtaining a CT-scan in all cases of suspected pneumonia has significant drawbacks. We used a cohort of 200 consecutive elderly patients admitted to the hospital for suspected pneumonia to build a simple prediction score, which was used to determine indication for performing a CT-scan. The reference diagnosis was adjudicated by experts considering all available data, including evolution until discharge and CT scan in all patients. Results were externally validated in a second cohort of 319 patients. Pneumonia was confirmed in 133 patients (67%). Area under the receiver operator curve (AUROC) of physician evaluation was 0.55 (0.46–0.64). The score incorporated four variables independently predicting confirmed pneumonia: male gender, acute cough, C-reactive protein >70 mg/L, and urea <7 mmol/L. AUROC of the score was 0.68 (95% confidence interval (CI) 0.60–0.76). When a CT-scan was obtained for patients at low or intermediate predicted risk (108 patients, 54% of the cohort), AUROC was 0.71 (0.63–0.80) and 0.69 (0.64–0.74) in the derivation and validation cohort, respectively. A simple prediction score for pneumonia had moderate accuracy and could guide the performance of a CT-scan.
How to Get the Most from Methotrexate (MTX) Treatment for Your Rheumatoid Arthritis Patient?—MTX in the Treat-to-Target Strategy
Authors: Taylor Peter. C. , Balsa Criado Alejandro , Mongey Anne-Barbara , Avouac Jerome , Marotte Hubert , Mueller Rudiger B.
Published: April 2019

Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-titratable range, options for either an oral or parenteral route of administration, and currently unrivalled cost-effectiveness. It has a place as a monotherapy and also as an anchor drug that can be safely used in combination with other conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) or used concomitantly with biological DMARDs or targeted synthetic DMARDs. MTX is not without potential issues regarding toxicity, notably hepatotoxicity and bone marrow toxicity, as well as tolerability problems for some, but not all, patients. But many of these issues can be mitigated or managed. In the face of a welcome expansion in available targeted therapies for the treatment of RA, MTX looks set to remain at the foundation of pharmacotherapy for the majority of people living with RA and other inflammatory rheumatic diseases. In this article, we provide an evidence-based discussion as to how to achieve the best outcomes with this versatile drug in the context of a treat-to-target strategy for the management of RA.
Clonal Dispersal of Cryptococcus gattii VGII in an Endemic Region of Cryptococcosis in Colombia
Authors: Firacative Carolina , Torres Germán , Meyer Wieland , Escandón Patricia
Published: April 2019

This study characterized the genotype and phenotype of Cryptococcus gattii VGII isolates from Cucuta, an endemic region of cryptococcal disease in Colombia, and compared these traits with those from representative isolates from the Vancouver Island outbreak (VGIIa and VGIIb). Genetic diversity was assessed by multilocus sequence typing (MLST) analysis. Phenotypic characteristics, including growth capacity under different temperature and humidity conditions, macroscopic and microscopic morphology, phenotypic switching, mating type, and activity of extracellular enzymes were studied. Virulence was studied in vivo in a mouse model. MLST analysis showed that the isolates from Cucuta were highly clonal, with ST25 being the most common genotype. Phenotypically, isolates from Cucuta showed large cell and capsular sizes, and shared phenotypic traits and enzymatic activities among them. The mating type a prevailed among the isolates, which were fertile and of considerable virulence in the animal model. This study highlights the need for a continuous surveillance of C. gattii in Colombia, especially in endemic areas like Cucuta, where the highest number of cryptococcosis cases due to this species is reported. This will allow the early detection of potentially highly virulent strains that spread clonally, and can help prevent the occurrence of outbreaks in Colombia and elsewhere.
Study of Toughness and Macro/Micro-Crack Development of Fibre-Reinforced Ultra-High Performance Concrete After Exposure to Elevated Temperature
Authors: Smarzewski Piotr
Published: April 2019

This study has investigated the changes that might appear in post-peak flexural response. Before the flexural test, prismatic specimens were placed in a furnace chamber and exposed to elevated temperatures of 400, 600, and 800 °C. The flexural toughness test was carried out on two types of concrete: Plain ultra-high performance concrete (UHPC) and UHPC with different types of fibres (steel fibre (SF) and polypropylene fibre (PPF)) at 0.5%, 1%, 1.5%, and 2% volume fractions. During the flexural test in the macro-crack development analysis, the non-contact ARAMIS system was used to perform three-dimensional measurements of strain and displacement. The results of scanning electron microscope (SEM) observations of micro-crack development in UHPC without and with SF/PPF were also presented. The experimental results showed that in some cases, the load–deflection curve of fibre-reinforced UHPC displayed a double-peak response. The first peak signified the UHPC properties, while the second peak represented the properties of the fibres. Under flexural load, the toughness decreased as the temperature increased. Significant decrease in the load–deflection response and toughness were observed for the polypropylene fibre-reinforced UHPC when the temperature approached 800 °C. The SEM observation results showed that the thermal damage of fibre-reinforced UHPC depends on the pore pressure effect, the thermal mismatch, the decomposition of hydration products, and the formation of micro-cracks.
Synthesis and Luminescence of Optical Memory Active Tetramethylammonium Cyanocuprate(I) 3D Networks
Authors: Nicholas Aaron D. , Bullard Rebeka M. , Wheaton Amelia M. , Streep Michaela , Nicholas Victoria A. , Pike Robert D. , Patterson Howard H.
Published: April 2019

The structures of three tetramethylammonium cyanocuprate(I) 3D networks [NMe4]2[Cu(CN)2]2•0.25H2O (1), [NMe4][Cu3(CN)4] (2), and [NMe4][Cu2(CN)3] (3), (Me4N = tetramethylammonium), and the photophysics of 1 and 2 are reported. These complexes are prepared by combining aqueous solutions of the simple salts tetramethylammonium chloride and potassium dicyanocuprate. Single-crystal X-ray diffraction analysis of complex 1 reveals {Cu2(CN)2(μ2-CN)4} rhomboids crosslinked by cyano ligands and D3h {Cu(CN)3} metal clusters into a 3D coordination polymer, while 2 features independent 2D layers of fused hexagonal {Cu8(CN)8} rings where two Cu(I) centers reside in a linear C∞v coordination sphere. Metallophilic interactions are observed in 1 as close Cu⋯Cu distances, but are noticeably absent in 2. Complex 3 is a simple honeycomb sheet composed of trigonal planar Cu(I) centers with no Cu…Cu interactions. Temperature and time-dependent luminescence of 1 and 2 have been performed between 298 K and 78 K and demonstrate that 1 is a dual singlet/triplet emitter at low temperatures while 2 is a triplet-only emitter. DFT and TD-DFT calculations were used to help interpret the experimental findings. Optical memory experiments show that 1 and 2 are both optical memory active. These complexes undergo a reduction of emission intensity upon laser irradiation at 255 nm although this loss is much faster in 2. The loss of emission intensity is reversible in both cases by applying heat to the sample. We propose a light-induced electron transfer mechanism for the optical memory behavior observed.
Effect of Phenolic Resin on Micropores Development in Carbon Foam with High Performance
Authors: Dang Alei , Zhao Zhao , Tang Chen , Fang Chenglin , Kong Siyuan , Khan Muhammad , Li Tiehu , Zhao Tingkai , Li Hao
Published: April 2019

A novel high-performance carbon foam (CF) was fabricated through the addition of phenolic resin (PR) into a coal tar pitch (CTP) based precursor. The effects of mass fraction of a PR additive on the crystalline structures, morphologies, compressive strength (σ) and thermal conductivity (λ) of resultant CF material were investigated systematically. Characterization showed a strong dependence of CF’s performance from the composition and optical texture of the precursor, which were mainly depending on the polycondensation and polymerization reactions between PR and raw CTP. Comparing with the strength of pristine CF at 6.5 MPa, the σ of mCF-9 (13.1 MPa) was remarkably enhanced by 100.1%. However, the λ of mCF-9 substantially reduced to 0.9 m−1K−1 compared with 18.2 W m−1K−1 of pristine CF. Thus, this modification strategy to produce microporous CF materials from raw CTP provides a new protocol for the fabrication of high-performance carbon based materials.
Polymer Processing: Modeling and Correlations Finalized to Tailoring Plastic Part Morphology and Properties
Authors: Titomanlio Giuseppe , Speranza Vito
Published: April 2019

The analysis of polymer processing operations requires the description of simultaneous transient momentum and heat transfer down to material solidification. The aim of the analysis is to improve and, hopefully, optimize the final properties that are determined by the final morphology of the part. In this special issue, consisting of 1 review and 11 research articles detailing several polymer processing operations, experimental and numerical analyses have been conducted in order to identify and describe the main relevant phenomena, that affect the product morphologies and properties.
Gd/Sm-Pr Co-Doped Ceria: A First Report of the Precipitation Method Effect on Flash Sintering
Authors: Spiridigliozzi Luca , Pinter Lorenzo , Biesuz Mattia , Dell’Agli Gianfranco , Accardo Grazia , Sglavo Vincenzo M.
Published: April 2019

In this work, ceria-based ceramics with the composition Gd0.14Pr0.06Ce0.8O2-δ and Sm0.14Pr0.06Ce0.8O2-δ, were synthesized by a simple co-precipitation process using either ammonium carbonate or ammonia solution as a precipitating agent. After the calcination, all of the produced samples were constituted by fluorite-structured ceria only, thus showing that both dopant and co-dopant cations were dissolved in the fluorite lattice. The ceria-based nanopowders were uniaxially compacted and consequently flash-sintered using different electrical cycles (including current-ramps). Different results were obtained as a function of both the adopted precipitating agent and the applied electrical cycle. In particular, highly densified products were obtained using current-ramps instead of “traditional” flash treatments (with the power source switching from voltage to current control at the flash event). Moreover, the powders that were synthesized using ammonia solution exhibited a low tendency to hotspot formation, whereas the materials obtained using carbonates as the precipitating agent were highly inhomogeneous. This points out for the first time the unexpected relevance of the precipitating agent (and of the powder shape/degree of agglomeration) for the flash sintering behavior.
Broadband Perfect Optical Absorption by Coupled Semiconductor Resonator-Based All-Dielectric Metasurface
Authors: Weng Zhi , Guo Yunsheng
Published: April 2019

Resonance absorption mechanism-based metasurface absorbers can realize perfect optical absorption. Further, all-dielectric metasurface absorbers have more extensive applicability than metasurface absorbers that contain metal components. However, the absorption peaks of the all-dielectric metasurface absorbers reported to date are very sharp. In this work, we propose a broadband optical absorption all-dielectric metasurface, where a unit cell of this metasurface is composed of two coupled subwavelength semiconductor resonators arrayed in the direction of the wave vector and embedded in a low-index material. The results indicate that the peak absorption for more than 99% is achieved across a 60 nm bandwidth in the short-wavelength infrared region. This absorption bandwidth is three times that of a metasurface based on the conventional design scheme that consists of only a single layer of semiconductor resonators. Additionally, the coupled semiconductor resonator-based all-dielectric metasurface shows robust perfect absorption properties when the geometrical and material parameters—including the diameter, height, permittivity, and loss tangent of the resonator and the vertical and horizontal distances between the two centers of the coupled resonators—are varied over a wide range. With the convenience of use of existing semiconductor technologies in micro/nano-processing of the surface, this proposed broadband absorption all-dielectric metasurface offers a path toward realizing potential applications in numerous optical devices.
Effects of Aluminum Sulfate and Quicklime/Fluorgypsum Ratio on the Properties of Calcium Sulfoaluminate (CSA) Cement-Based Double Liquid Grouting Materials
Authors: Wang Yuli , Yu Jie , Wang Junjie , Guan Xuemao
Published: April 2019

Grouting materials are used frequently in grouting reinforcement projects, such as mining and coastal engineering. Double liquid grouting materials are mostly used because of the fast setting and high early strength properties when the two slurries are mixed together but high fluidity when the two slurries are separated. In our study, double liquid grouting materials were developed from CSA cement (slurry A), quicklime and fluorgypsum (slurry B). Aluminum sulfate was added in slurry B in order to counteract any adverse effects caused by the fluorgypsum, such as the decreased early compressive strength and the prolonged setting time. The effects of aluminum sulfate content and the quicklime/fluorgypsum ratio on the setting time, hydration heat, and compressive strength of the double liquid grouting materials were investigated, and the hydration products were characterized through thermogravimetry-differential thermal analysis (TG-DTA), X-ray Diffraction (XRD), and Scanning Electron Microscope (SEM) tests. The results show that the addition of aluminum sulfate can shorten the setting time and increase compressive strength at both early and later ages. Considering the setting time and compressive strength of double liquid grouting material at the same time, the optimum content of aluminum sulfate was found to be 2%, and the optimum ratio of quicklime/fluorgypsum was found to be 2:8. The values of the optimum content of aluminum sulfate and ratio of quicklime/fluorgypsum were verified from theoretical analysis.
Effects of Ball Milling Processing Conditions and Alloy Components on the Synthesis of Cu-Nb and Cu-Mo Alloys
Authors: Shang Xuekun , Wang Xitao , Chen Silian
Published: April 2019

The effects of processing parameters in ball milling and the different behaviors of Cu-Nb and Cu-Mo alloys during milling were investigated. High powder yields can be obtained by changing the BPR value and ball size distribution and no clear dependence of BPR value on powder yield can be found from the experiment results. The addition of oxygen can largely reduce the effect of excessive cold welding during ball milling. A “two-step” ball milling method was introduced to evaluate the different evolution processes and morphologies in different alloys. With 8 h pre-milling, this method considerably benefits the oxidation process of Mo and shows its promising potential in the synthesis of immiscible alloys. Based on the experiment results and analysis, we suggest that the different behaviors of Cu-Nb and Cu-Mo alloys are related to the shear modules and different tendencies to be oxidized.
Static and Dynamic Loading Behavior of Ti6Al4V Honeycomb Structures Manufactured by Laser Engineered Net Shaping (LENSTM) Technology
Authors: Antolak-Dudka Anna , Płatek Paweł , Durejko Tomasz , Baranowski Paweł , Małachowski Jerzy , Sarzyński Marcin , Czujko Tomasz
Published: April 2019

Laser Engineered Net Shaping (LENSTM) is currently a promising and developing technique. It allows for shortening the time between the design stage and the manufacturing process. LENS is an alternative to classic metal manufacturing methods, such as casting and plastic working. Moreover, it enables the production of finished spatial structures using different types of metallic powders as starting materials. Using this technology, thin-walled honeycomb structures with four different cell sizes were obtained. The technological parameters of the manufacturing process were selected experimentally, and the initial powder was a spherical Ti6Al4V powder with a particle size of 45–105 µm. The dimensions of the specimens were approximately 40 × 40 × 10 mm, and the wall thickness was approximately 0.7 mm. The geometrical quality and the surface roughness of the manufactured structures were investigated. Due to the high cooling rates occurring during the LENS process, the microstructure for this alloy consists only of the martensitic α’ phase. In order to increase the mechanical parameters, it was necessary to apply post processing heat treatment leading to the creation of a two-phase α + β structure. The main aim of this investigation was to study the energy absorption of additively manufactured regular cellular structures with a honeycomb topology under static and dynamic loading conditions.
The Expansion Cracks of Dolomitic Aggregates Cured in TMAH Solution Caused by Alkali–Carbonate Reaction
Authors: Chen Xiaoxiao , Yang Bin , Mao Zhongyang , Deng Min
Published: April 2019

In this study, concrete microbars and rock prisms made of dolomitic aggregates were cured in a 1-mol/L tetramethylammonium hydroxide (TMAH) solution at 80 °C to avoid the effect of alkali–silica reaction (ASR) on expansion. The expansion of specimens was only caused by the alkali–carbonate reaction (ACR). The reason that self-made cement was used in this work was to ensure that the Mg2+ contained in the brucite originated only from dolomite. Expansion of concrete microbars and rock prisms was measured, the expansion cracks were systematically observed by orthogonal polarizing microscopy, and the products of ACR were analyzed by scanning electron microscopy (SEM) and energy dispersive spectrometry (EDS). The results showed that the dolomite crystals in the dolomitic aggregates reacted with the TMAH solution and resulted in ACR, which formed calcite and brucite and led to cracking of the specimens. The source of the expansion was the dolomite crystals of the dolomite enrichment area. Expansion cracks either extended inside the rock or into the cement phase and eventually disappeared. The alkali–carbonate reaction significantly contributed to the expansion of dolomitic aggregates cured in TMAH solution at a later curing age.
The Influence of Non-Uniformities on the Mechanical Behavior of Hemp-Reinforced Composite Materials with a Dammar Matrix
Authors: Bolcu Dumitru , Stănescu Marius Marinel
Published: April 2019

As a result of manufacture, composite materials can appear to have variations to their properties due to the existence of structural changes. In this paper, we studied the influence of material irregularity on the mechanical behavior of two categories of bars for which we have used hemp fabric as a reinforcing material. The common matrix is a hybrid resin based on Dammar and epoxy resin. We molded two types of bars within each of the previously mentioned categories. The first type, also called “ideal bar”, was made of layers in which the volume proportion and the orientation of the reinforcing material was the same in each section. The ideal bar does not show variations of mechanical properties along it. The second type of bar was molded to have one or two layers where, between certain sections, the reinforcing material was interrupted in several segments. We have determined some mechanical properties, the characteristic curves (strain-stress), the tensile strength, and elongation at break for all the sample sets on trial. Moreover, we have studied the influence of the non-uniformities on the mechanical behavior of the composites by entering certain quality factors that have been calculated after experimental determinations.
The Investigation of High-Temperature SAW Oxygen Sensor Based on ZnO Films
Authors: Shu Lin , Wang Xuemin , Yan Dawei , Fan Long , Wu Weidong
Published: April 2019

In this paper, a wireless oxygen sensor based on a surface acoustic wave (SAW) was reported. For high-temperature applications, novel Al2O3/ZnO/Pt multilayered conductive film was deposited on langasite substrate as the electrodes, and ZnO film obtained by the pulse laser deposition (PLD) method was used as the sensitive film. The measurements of X-ray diffraction (XRD) and a scanning electron microscope (SEM) showed that the c-axis orientation of the ZnO grains and the surface morphology of the films were regulated by the deposition temperature. Meanwhile, the gas response of the sensor was strongly dependent on the surface morphology of the ZnO film. The experimental results showed that the oxygen gas sensor could operate at a high-temperature environment up to 850 °C with good stability for a long period. The max frequency shift of the sensors reaches 310 kHz, when exposed to 40% O2 gas at 850 °C. The calculated standard error of the sensors in a high-temperature measurement process is within 3%. Additionally, no significant signal degradation could be observed in the long-term experimental period. The prepared SAW oxygen gas sensor has potential applications in high-temperature sensing systems.
High-Quality Perovskite CH3NH3PbI3 Thin Films for Solar Cells Prepared by Single-Source Thermal Evaporation Combined with Solvent Treatment
Authors: Peng Huanxin , Su Zhenghua , Zheng Zhuanghao , Lan Huabin , Luo Jingting , Fan Ping , Liang Guangxing
Published: April 2019

In this work, solvent annealing process for CH3NH3PbI3 thin film prepared by single source evaporation was reported. Characterized by the scanning electron microscope (SEM), X-ray diffractometer (XRD), energy dispersive spectroscope (EDS), ultraviolet-visible (UV) spectrophotometer, and the photoluminescence (PL) spectrometer, our method ensured higher quality film with crystallinity, composition, well-defined grain structure, and reproducibility. The optimized solar cell device based on the structure of ITO/PEDOT:PSS/CH3NH3PbI3/PCBM/Ag achieved better performance in power conversion efficiency from 2.64% to 9.92%, providing an effective method to optimize the quality of perovskite film for solar cell application.
Tie-System Calibration for the Experimental Setup of Large Deployable Reflectors
Authors: Cammarata Alessandro , Sinatra Rosario , Rigato Riccardo , Maddio Pietro Davide
Published: April 2019

The trade-off between the design phase and the experimental setup is crucial in satisfying the accuracy requirements of large deployable reflectors. Manufacturing errors and tolerances change the root mean square (RMS) of the reflecting surface and require careful calibration of the tie-rod system to be able to fit into the initial design specifications. To give a possible solution to this problem, two calibration methods—for rigid and flexible ring truss supports, respectively—are described in this study. Starting from the acquired experimental data on the net nodal co-ordinates, the initial problem of satisfying the static equilibrium with the measured configuration is described. Then, two constrained optimization problems (for rigid or flexible ring truss supports) are defined to meet the desired RMS accuracy of the reflecting surface by modifying the tie lengths. Finally, a case study to demonstrate the validity of the proposed methods is presented.
The Influence of an Eight-Week Cycloergometer-Based Cardiac Rehabilitation on Serum Antioxidant Status in Men with Coronary Heart Disease: A Prospective Study
Authors: Gawron-Skarbek Anna , Chrzczanowicz Jacek , Kostka Joanna , Nowak Dariusz , Drygas Wojciech , Jegier Anna , Kostka Tomasz
Published: April 2019

Background and objectives: A body of evidence confirms the benefits of cardiac rehabilitation (CR) in coronary heart disease (CHD) patients, but it remains unclear whether it enhances the antioxidant potential. The aim of the study was to assess the influence of an eight-week aerobic cycloergometer-based CR program on serum total antioxidant capacity (TAC) and other CHD risk factors. Materials and Methods: The study involved 36 men with CHD (55.2 ± 9.0 years). TAC was assessed with two methods: ferric reducing ability of serum (TAC-FRAS) and 2.2-diphenyl-1-picryl-hydrazyl (TAC-DPPH). Aerobic capacity was evaluated during a submaximal exercise test. TAC and other anthropometric, biochemical and physical activity/fitness measures were performed twice: before the beginning and after termination of CR. Results: Aerobic capacity was higher (7.0 ± 2.6 vs. 8.0 ± 2.5 MET—metabolic equivalents; p < 0.01), but values of resting diastolic blood pressure were lower (81.9 ± 7.6 vs. 77.4 ± 8.9 mmHg; p < 0.01) after termination of CR. Other classic cardiometabolic, anthropometric, and biochemical measures did not change with CR. No difference in TAC-FRAS was found after CR, whereas TAC-DPPH was significantly lower (16.4 ± 4.0 vs. 13.2 ± 3.7% reduction; p < 0.01). Conclusions: Antioxidant potential measured as TAC-DPPH, but not as TAC-FRAS, decreased with the CR program. The recognized health benefits of CR are not related to augmented serum antioxidant status.
Electrochemical Corrosion Behavior of Fe3Al/TiC and Fe3Al-Cr/TiC Coatings Prepared by HVOF in NaCl Solution
Authors: Ahledel Najmeh , Schulz Robert , Gariepy Mario , Hermawan Hendra , Alamdari Houshang
Published: April 2019

Adding TiC particles into iron aluminide coatings has been found to improve its wear resistance, but its corrosion behavior is less known. In this study, the corrosion behavior of Fe3Al/TiC and Fe3Al-Cr/TiC composite coatings, prepared by high velocity oxy fuel (HVOF) spraying, was studied in 3.5 wt. % NaCl solution by means of electrochemical techniques and surface analysis. Results revealed that adding TiC particles into Fe3Al matrix to improve the wear resistance does not deteriorate the corrosion behavior of Fe3Al coating. It was also showed that addition of chromium to Fe3Al/TiC composite provides a more protective layer.
Laser-Ignited Self-Propagating Sintering of AlCrFeNiSi High-Entropy Alloys: An Improved Technique for Preparing High-Entropy Alloys
Authors: An Ya-Jun , Zhu Li , Jin Si-Han , Lu Jing-Jing , Liu Xian-Yang
Published: April 2019

AlCrFeNiSi system porous high-entropy alloy material is manufactured by laser ignition and self-propagating sintering of natural chromite powder, which provides the idea of breaking the traditional synthesis procedure of high-entropy alloy compound material. The raw material powder obtained by ball milling is compacted into cylindrical compacts, and the self-propagating reaction comes from the ignition caused by the laser on the surface of compacts, the high-entropy alloy composite of chrome iron powder synthesized by laser sintering, is obtained as well. The raw material is prepared from Al, Cr, Fe, Ni and Si elements with similar effective components of natural chromite powder. The selected chromite powder is energy-saving and environment-friendly, so the preparation of high-entropy alloy by the low-cost short-process can be made for processing for pre-theoretical reserve and process design. The effect of Si content on microstructure and properties of AlCrFeNiSi high-entropy alloy is investigated.
Development of a Novel Resistance Heating System for Microforming Using Surface-Modified Dies and Evaluation of Its Heating Property
Authors: Yang Ming , Shimizu Tetsuhide
Published: April 2019

For this study, a novel resistance heating system for microforming was developed using surfaces of forming dies as heating resources. The electrical resistance of the die surfaces was designed and the hard-coating material AlCrSiN was selected to coat the die surfaces for heating. To clarify the effects of the thickness and modified surfaces on heating efficiency, the temperature and stress reduction were evaluated in a micro-compression test using dies coated with 0.5 and 1 μm AlCrSiN films. Furthermore, the formability was also demonstrated using 1 μm thick AlCrSiN-coated tools in a microforging test. By applying surface-modified dies to the forming processes, we found that not only was the heating efficiency improved, but also the dependence of heating on the product’s shape and the material’s electrical properties was reduced.
CFM-ID 3.0: Significantly Improved ESI-MS/MS Prediction and Compound Identification
Authors: Djoumbou-Feunang Yannick , Pon Allison , Karu Naama , Zheng Jiamin , Li Carin , Arndt David , Gautam Maheswor , Allen Felicity , Wishart David S.
Published: April 2019

Metabolite identification for untargeted metabolomics is often hampered by the lack of experimentally collected reference spectra from tandem mass spectrometry (MS/MS). To circumvent this problem, Competitive Fragmentation Modeling-ID (CFM-ID) was developed to accurately predict electrospray ionization-MS/MS (ESI-MS/MS) spectra from chemical structures and to aid in compound identification via MS/MS spectral matching. While earlier versions of CFM-ID performed very well, CFM-ID’s performance for predicting the MS/MS spectra of certain classes of compounds, including many lipids, was quite poor. Furthermore, CFM-ID’s compound identification capabilities were limited because it did not use experimentally available MS/MS spectra nor did it exploit metadata in its spectral matching algorithm. Here, we describe significant improvements to CFM-ID’s performance and speed. These include (1) the implementation of a rule-based fragmentation approach for lipid MS/MS spectral prediction, which greatly improves the speed and accuracy of CFM-ID; (2) the inclusion of experimental MS/MS spectra and other metadata to enhance CFM-ID’s compound identification abilities; (3) the development of new scoring functions that improves CFM-ID’s accuracy by 21.1%; and (4) the implementation of a chemical classification algorithm that correctly classifies unknown chemicals (based on their MS/MS spectra) in >80% of the cases. This improved version called CFM-ID 3.0 is freely available as a web server. Its source code is also accessible online.
A Decoupling Design with T-Shape Structure for the Aluminum Nitride Gyroscope
Authors: Yang Jian , Si Chaowei , Han Guowei , Zhang Meng , Ning Jin , Zhao Yongmei , Yang Fuhua , Wang Xiaodong
Published: April 2019

This paper reports a novel design for the decoupling of microelectromechanical systems (MEMS) gyroscopes. The MEMS gyroscope is based on piezoelectric aluminum nitride (AlN) film, and the main structure is a mass hung by T-shape beams. A pair of parallel drive electrodes are symmetrically placed on the surface of the vertical bar for driving the oscillating mass. A serpentine sense electrode is placed on the lateral bar. When the gyroscope is oscillating in drive mode, charges with equal quantity and opposite sign will be polarized and distributed symmetrically along the lateral bar. These charges neutralize each other at the sense electrode. Therefore, no coupling signals can be detected from the sense electrode. This design can realize the decoupling between the drive mode and sense mode. In this work, the T-shape decoupled structure was designed as the key component of an AlN piezoelectric gyroscope and the whole structure was simulated by COMSOL Multiphysics 5.2a. The working principle of the decoupling is described in detail. Electrical properties were characterized by the dynamic signal analyzer. According to the test results, the drive mode and the sense mode are decoupled. The coefficient of orthogonal coupling is 1.55%.
The Effect of the Ionic Strength of Process Water on the Interaction of Talc and CMC: Implications of Recirculated Water on Floatable Gangue Depression
Authors: Manono Malibongwe , Corin Kirsten , Wiese Jenny
Published: April 2019

Previous studies speculate that hydroxo species present in flotation pulps at pH > 9, particularly those of polyvalent cations, selectively adsorb onto gangue minerals. Such species supposedly enhance the depressive action of carboxymethyl cellulose (CMC) onto gangue via an acid-base interaction between the positively charged mineral surface and the negatively charged CMC molecule. Thus, the hydrophilicity of gangue minerals is enhanced, preventing the dilution of the concentrate. However, as there is little evidence to support these claims for complex process waters of increasing ionic strength, it is important to investigate. Adsorption data and mineral surface charge analyses provide a fundamental understanding of how electrolytes and their ionic strengths affect gangue mineral-depressant adsorption. It is strongly anticipated that decoupling these effects will allow process operators to tailor their process water quality needs towards best flotation operating regimes and, in the long run, effect closed water circuits. Thus, using talc as a proxy for naturally floatable gangue common in sulfidic Cu–Ni–PGM ores, this work investigates the influence of the ionic strength of process water on the adsorption of CMC onto talc for a perspective on how saline water in sulfidic ores would affect the behavior and therefore management of floatable gangue. In the presence of CMC, the microflotation results showed that the rate of talc recovery decreased with increasing ionic strength of process water. Increases in ionic strength resulted in an increase in the adsorption of CMC onto talc. Talc particles proved to have been more coagulated at higher ionic strength since the settling time decreased with increasing ionic strength. Furthermore, the zeta potential of talc particles became less negative at higher ionic strengths of process water. It is thus proposed that increases in the ionic strength of process water increased the zeta potential of talc particles, enhancing the adsorption of CMC onto talc. This in turn created a more coagulated nature on talc particles, increasing their hydrophilicity and thereby retarding floatability.
Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials
Authors: Silvestro Serena , Mammana Santa , Cavalli Eugenio , Bramanti Placido , Mazzon Emanuela
Published: April 2019

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest thanks to its medical applications. This compound showed efficacy as anti-seizure, antipsychotic, neuroprotective, antidepressant and anxiolytic. The neuroprotective activity appears linked to its excellent anti-inflammatory and antioxidant properties. The purpose of this paper is to evaluate the use of CBD, in addition to common anti-epileptic drugs, in the severe treatment-resistant epilepsy through an overview of recent literature and clinical trials aimed to study the effects of the CBD treatment in different forms of epilepsy. The results of scientific studies obtained so far the use of CBD in clinical applications could represent hope for patients who are resistant to all conventional anti-epileptic drugs.