bluuebunny/crossref_metadata_2025 huggingface dataset:
Sociodemographic, psychological, and clinical characteristics associated with health service (non-)use for mental disorders in adolescents and young adults from the general population
Authors: Reich H. , Niermann H. C. M. , Voss C. , Venz J. , Pieper L. , Beesdo-Baum K.
Published: February 2023

Most adolescents and young adults who experience psychological distress do not seek professional help. This study aims to enhance the understanding of sociodemographic, psychological, and clinical characteristics associated with the underuse of health services by adolescents and young adults with mental disorders. Data from a cross-sectional, epidemiological study with a population-based sample (N = 1180 participants, 14–21 years old) were used. Participants completed a fully standardized, computer-assisted diagnostic interview (DIA-X-5/D-CIDI) administered by trained clinical interviewers to assess lifetime mental disorders according to DSM-5 as well as lifetime health service use for mental health problems, and completed self-report questionnaires to assess various psychological variables (e.g., stigma). Predictors of health service use were examined using univariate and multiple logistic regression analyses, data were weighted for age and sex to improve representativeness Of n = 597 participants with any lifetime mental disorder, 32.4% [95% CI 28.4; 36.7] had ever used any health services because of a mental health, psychosomatic, or substance use problem. Even less had received psychotherapeutic or pharmacological treatment (Cognitive Behavioral Therapy: 12.1% [9.5; 15.2]; other psychotherapy: 10.7% [8.4; 13.7]; medication: 5.4% [3.7; 7.8]). High education was associated with less health service use (low/ middle/ other vs. high education: 53.8% vs. 26.9%; OR = 0.26, p < .001). In the multiple regression model, stigma toward mental disorders was the single psychological variable associated with a reduced likelihood of using health services (OR = 0.69 [0.52; 0.90], p < .01). These findings draw attention to the treatment gap for mental disorders during adolescence and highlight related factors to be addressed in public health contexts.
Effect of display of YOLO’s object recognition results to HMD for an operator controlling a mobile robot
Authors: Sasaki Yuichi , Kamegawa Tetsushi , Gofuku Akio
Published: February 2023

An operator feels a burden when he/she controls a rescue robot remotely because he/she has to keep watching camera images to find the target object. We think that this burden can be reduced by the combination of Head Mounted Display (HMD) and object recognition by deep learning. In the first half part of this study, we examine the effect that how presentation method by You Only Look Once (YOLO), a deep learning algorithm, and its recognition results to an operator wearing HMD. In the experiment, three methods of presentation were set: no display of object recognition, display only one object recognition result, and display 80 kinds of object recognition results. Under each presentation method, we measured the time it took for the operator to operate the robot and complete the given task. Additionally, we ask a questionnaire for each experiment. The results of the questionnaire showed that the method to present only one object recognition result was useful. In the second half part of this study, we develop a system to present 3D images with YOLO added, to further ease the burden of object search. Furthermore, we numerically prove that this system represents depth. In the experiment, two methods of displaying were set up: 2D images with Bounding Box (BB) by YOLO and 3D images with BB by YOLO. For each method of presentation, the operator operated the robot and recorded the number of objects found within a time limit. Additionally, we asked a questionnaire at the end of the search in each condition and at the end of all the experiments. The results of the questionnaire suggested points that need to be improved. Furthermore, we consider the flicker of the image found in the experiment.
The Hungarian insurance market structure: an empirical analysis
Authors: Varga Veronika , Madari Zoltán
Published: February 2023

This paper analyzes the market structure of the Hungarian insurance market, which operated as a monopoly market until 1986. After the regime change this sector started to develop rapidly. But the Hungarian insurance market has a strong oligopolistic character, and thus raises an interesting question as to how close the market is to a state of perfect competition. Based on the Panzar and Rosse (J Ind Econ 35:443–456, 1987) methodology we estimate the elasticity of total revenues with respect to changes in input prices, so that we can determine the market structure. The estimation of input price elasticity is made with a static and a dynamic panel model. According to research the structure of the Hungarian insurance market significantly differs from the perfect competition case between 2010 and 2019. The market is in long-run equilibrium, and the hypothesis of the monopoly case cannot be rejected. The market structure of a sector is important for modelling phenomena and new regulations effectively, which is relevant for insurance and competition supervision in the protection of customers.
Efficacy and safety of super pulse CO2 laser-assisted punctoplasty with canalicular curettage in primary canaliculitis
Authors: Huang Weifeng , Cao Shujuan , Xie Lingling , Li Xingyi , Meng Ziwei , Yu Xinyue , Huang Danping , Chen Rongxin , Liang Xuanwei
Published: February 2023

The objective of this study was to evaluate the efficacy and safety of super pulse CO2 laser-assisted punctoplasty with canalicular curettage in primary canaliculitis. In this retrospective serial case study, the clinical data of 26 patients who underwent super pulse CO2 laser-assisted punctoplasty for the treatment of canaliculitis were collected from January 2020 to May 2022. The clinical presentation, intraoperative and microbiologic findings, surgical pain severity, postoperative outcome, and complications were studied. Of the 26 patients, most were females (female:male 20:6), with a mean age of 60.1 ± 16.1 years (range, 19–93). Mucopurulent discharge (96.2%), eyelid redness and swelling (53.8%), and epiphora (38.5%) were the most common presentations. During the surgery, concretions were present in 73.1% (19/26) of the patients. The surgical pain severity scores ranged from 1 to 5, according to the visual analog scale, with a mean score of 3.2 ± 0.8. This procedure resulted in complete resolution in 22 (84.6%) patients and significant improvement in 2 (7.7%) patients, and 2 (7.7%) patients required additional lacrimal surgery with a mean follow-up time of 10.9 ± 3.7 months. The surgical procedure of super pulse CO2 laser-assisted punctoplasty followed by curettage appears to be a safe, effective, minimally invasive, and well-tolerated treatment for primary canaliculitis.
Opportunities for blue carbon restoration projects in degraded agricultural land of the coastal zone in Queensland, Australia
Authors: Rowland Phebe I. , Hagger Valerie , Lovelock Catherine E.
Published: February 2023

Restoring degraded agricultural lands to their original coastal wetland cover is an approach for enhancing blue carbon storage. This approach enhances carbon sequestration in biomass and soils whilst reducing greenhouse gas emissions and delivering other conservation benefits such as enhancing biodiversity, improving water quality, and protecting coastlines from sea level rise. In Queensland, Australia, tens of thousands of hectares of coastal land have been converted to agriculture since the 1900s, often through drainage. We evaluated the characteristics of degraded agricultural land to identify opportunities for blue carbon restoration projects. Degraded agricultural land was identified through visual inspection of satellite imagery. Our analysis revealed degradation was associated with historical Melaleuca-dominated wetland vegetation and current land uses other than intensive agriculture. Field sampling of a subset of paired degraded and non-degraded sites found that water content, organic carbon, and electrical conductivity were significantly higher at degraded sites. We also observed standing water, drainage structures, and dead trees at degraded sites. From our analyses, we inferred land degradation is likely caused by waterlogging, salinisation, and land management choices. Degraded land historically vegetated by Melaleuca-dominated wetlands could be targeted for blue carbon restoration projects that protect remaining soil carbon and enhance carbon storage, restore ecosystem services, and provide new income streams for landowners. Further characterisation of the distribution of degraded lands may contribute to prioritisation of sites suitable for restoration.
Projected solutions for finite-dimensional quasiequilibrium problems
Authors: Castellani Marco , Giuli Massimiliano , Latini Sara
Published: February 2023

The concept of projected solution has been introduced in Aussel et al. (J Optim Theory Appl 170:818–837, 2016) for studying quasivariational problems where the constraint map may not be a self-map. Aim of this paper is to establish a new result on the existence of projected solutions for finite-dimensional quasiequilibrium problems without any monotonicity assumptions and without assuming the compactness of the feasible set. These two facts allow us to improve some recent results. Additionally, we deduce the existence of projected solutions for quasivariational inequalities, quasioptimization problems and generalized Nash equilibrium problems. Also, a comparison with similar results is provided.
Mapping suitable habitat for Nigeria–Cameroon chimpanzees in Kom-Wum Forest Reserve, North-Western Cameroon
Authors: Fotang Chefor , Bröring Udo , Roos Christian , Dutton Paul , Tédonzong Luc Roscelin Dongmo , Willie Jacob , Angwafo Tsi Evaristus , Yuh Yisa Ginath , Schierack Peter , Birkhofer Klaus
Published: February 2023

Great apes lose suitable habitats required for their reproduction and survival due to human activities across their distribution range in Africa. Little is known about habitat suitability of the Nigeria–Cameroon chimpanzee [Pan troglodytes ellioti(Matschie, 1914)], particularly for populations inhabiting forest reserves in North-West Cameroon. To address this knowledge gap, we employed a common species distribution model (MaxEnt) to map and predict suitable habitats for the Nigeria–Cameroon chimpanzee in Kom-Wum Forest Reserve, North-West Cameroon, based on environmental factors that potentially affect habitat suitability. We related these environmental factors to a dataset of chimpanzee occurrence points recorded during line transect and reconnaissance (recce) surveys in the forest reserve and surrounding forests.  Up to 91% of the study area is unsuitable for chimpanzees. Suitable habitats only represented 9% of the study area, with a high proportion of highly suitable habitats located outside the forest reserve. Elevation, secondary forests density, distance to villages and primary forests density were the most important predictors of habitat suitability for the Nigeria–Cameroon chimpanzee. The probability of chimpanzee occurrence increased with elevation, secondary forest density and distance from villages and roads. Our study provides evidence that suitable chimpanzee habitat in the reserve is degraded, suggesting that efforts to maintain protected areas are insufficient. The reserve management plan needs to be improved to conserve the remaining suitable habitat and to avoid local extinction of this endangered subspecies.
Parental food provisioning and nestling growth under Philornis downsi parasitism in the Galapagos Green Warbler-Finch, classified as ‘vulnerable’ by the IUCN
Authors: Pike Courtney L. , Kofler Barbara , Richner Heinz , Tebbich Sabine
Published: February 2023

In the Galapagos Islands, many endemic landbird populations are declining due to habitat degradation, food availability, introduced species and other factors. Given nestlings typically lack efficient defense mechanisms against parasites, hematophagous ectoparasites such as the larvae of the introduced Avian Vampire Fly,Philornis downsi, can impose high brood mortality and cause threatening population declines in Darwin finches and other landbirds. Here, we assess whether the food compensation hypothesis (i.e., the parents’ potential to compensate for deleterious parasite effects via increased food provisioning) applies to the Green Warbler-Finch. We differentiated nests with low or high infestation levels byP.downsiand quantified food provisioning rates of male and female parents, time females spent brooding nestlings, and nestling growth. Male provisioning rates, total provisioning rates and female brooding time did not significantly vary in relation to infestation levels, nor by the number of nestlings. Opposed to the predictions of the food compensation hypothesis, females showed significantly reduced provisioning rates at high infestation levels. Nestling body mass was significantly lower and there was a reduction of skeletal growth, although not significantly, in highly infested nests. The females’ response to high infestation may be due to parasites directly attacking and weakening brooding females, or else that females actively reduce current reproductive effort in favor of future reproduction. This life-history trade-off may be typical for Darwin finches and many tropical birds with long lifespans and therefore high residual reproductive value. Conservation strategies may not build on the potential for parental food compensation by this species.
Validation of the Korean Version of Culturally Responsive Experiences in Close Relationships–Short Form
Authors: Lee Ji-yeon , Kim Yun-Kyung , Shin Yun-Jeong
Published: February 2023

The authors developed and validated the Korean version of the Experiences in Close Relationships—Short Form (K-ECRR-SF) with the goal of developing a culturally responsive scale. In study 1, a Rasch analysis was conducted on the 36 original items in the ECR-Revised (ECR-R) to select items that best represent anxiety and avoidance subscales by considering cultural equivalence. In study 2, confirmatory factor analysis (CFA) was conducted for the selected 12 items with a different sample. The factor structures of the ECR-R and K-ECRR-SF through CFA were then compared through CFA. In addition, the K-ECRR-SF items were tested for related constructs (i.e., reassurance and support seeking, loneliness, dyadic satisfaction, depression, anxiety, and fear of intimacy) to its criterion evidence. The newly developed K-ECRR-SF is confirmed to be valid and culturally responsive scale in measuring attachment in Korea.
Joining metadata and textual features to advise administrative courts decisions: a cascading classifier approach
Authors: Mentzingen Hugo , Antonio Nuno , Lobo Victor
Published: February 2023

Decisions of regulatory government bodies and courts affect many aspects of citizens’ lives. These organizations and courts are expected to provide timely and coherent decisions, although they struggle to keep up with the increasing demand. The ability of machine learning (ML) models to predict such decisions based on past cases under similar circumstances was assessed in some recent works. The dominant conclusion is that the prediction goal is achievable with high accuracy. Nevertheless, most of those works do not consider important aspects for ML models that can impact performance and affect real-world usefulness, such as consistency, out-of-sample applicability, generality, and explainability preservation. To our knowledge, none considered all those aspects, and no previous study addressed the joint use of metadata and text-extracted variables to predict administrative decisions. We propose a predictive model that addresses the abovementioned concerns based on a two-stage cascade classifier. The model employs a first-stage prediction based on textual features extracted from the original documents and a second-stage classifier that includes proceedings’ metadata. The study was conducted using time-based cross-validation, built on data available before the predicted judgment. It provides predictions as soon as the decision date is scheduled and only considers the first document in each proceeding, along with the metadata recorded when the infringement is first registered. Finally, the proposed model provides local explainability by preserving visibility on the textual features and employing the SHapley Additive exPlanations (SHAP). Our findings suggest that this cascade approach surpasses the standalone stages and achieves relatively high Precision and Recall when both text and metadata are available while preserving real-world usefulness. With a weighted F1 score of 0.900, the results outperform the text-only baseline by 1.24% and the metadata-only baseline by 5.63%, with better discriminative properties evaluated by the receiver operating characteristic and precision-recall curves.
Influence of wall-to-floor connections and pounding on pre- and post-diction simulations of a masonry building aggregate tested on a shaking table
Authors: Bianchini N. , Ciocci M. P. , Solarino F. , Romanazzi A. , Ramirez R. , D’Anna J. , Aşıkoğlu A.
Published: February 2023

This paper presents numerical simulations within the frame of the project SERA—AIMS (Seismic Testing of Adjacent Interacting Masonry Structures). The study includes blind pre-diction and post-diction stages. The former was developed before performing the shaking table tests at the laboratory facilities of LNEC (Lisbon), while the latter was carried out once the test results were known. For both, three-dimensional finite element models were prepared following a macro-modelling approach. The structure consisted of a half-scaled masonry aggregate composed by two units with different floor levels. Material properties used for the pre-diction model were based on preliminary tests previously provided to the participants. The masonry constitutive model used for the pre-diction study reproduced classical stress–strain envelope, whereas a more refined model was adopted for the post-diction. After eigenvalue analysis, incremental nonlinear time history analysis was performed under a unique sequence based on the given load protocol to account for damage accumulation. In the post-diction, the numerical model was calibrated on the data recorded during the shaking table tests and nonlinear dynamic analysis repeated under the recorded accelerogram sequence. The interaction between the two units was simulated through interface elements. Moreover, the timber floors were accounted following different strategies: not modelling or considering nonlinear wall-to-floor connections. Advantages and disadvantages are then analysed, comparing the pre-diction and post-diction results with the experimental data. Numerical results differ from the experimental outcomes regarding displacements and interface pounding, although a clear improvement is visible in the post-diction model.
Treatment and outcome in metastatic lobular breast cancer in the prospective German research platform OPAL
Authors: Thill M. , Zahn M.-O. , Welt A. , Stickeler E. , Nusch A. , Fietz T. , Rauh J. , Wetzel N. , Kruggel L. , Jänicke M. , Marschner N. , Harbeck N. , Wöckel A. , Decker T. ,   the OPAL study group
Published: February 2023

Purpose

Evidence about routine treatment and outcome of patients with invasive lobular cancer (ILC) is limited, especially regarding metastatic disease. Here we present prospective real-world data of patients with metastatic ILC (mILC) as compared to patients with metastatic invasive ductal cancer (mIDC) receiving systemic therapy in routine care in Germany.

Methods

Prospective data on patient and tumor characteristics, treatments, and outcomes of patients with mILC (n = 466) and mIDC (n = 2100), recruited between 2007 and 2021 into the Tumor Registry Breast Cancer/OPAL were analyzed.

Results

Compared to mIDCs, patients with mILC were older at start of first-line treatment (median 69 vs. 63 years) and had more often lower grade (G1/G2: 72.8% vs. 51.2%), hormone receptor (HR)-positive (83.7% vs. 73.2%) and less often HER2-positive (14.2% vs. 28.6%) tumors, which metastasized more frequently to the bone (19.7% vs. 14.5%) or peritoneum (9.9% vs. 2.0%), and less frequently to the lungs (0.9% vs. 4.0%). Median OS of patients with mILC (n = 209) and mIDC (n = 1158) was 30.2 months [95% confidence interval (CI) 25.3, 36.0] and 33.7 months [95% CI 30.3, 37.9], respectively. Multivariate survival analysis did not show a significant prognostic impact of the histological subtype [HR mILC vs. mIDC 1.18 (95% CI 0.97–1.42)].

Conclusion

Overall, our real-world data confirm clinicopathological differences between mILC and mIDC breast cancer patients. Despite patients with mILC presenting with some favorable prognostic factors, ILC histopathology was not associated with a better clinical outcome in multivariate analysis, suggesting the need for more tailored treatment strategies for patients with the lobular subtype.
Parenting and Serious Mental Illness (SMI): A Systematic Review and Metasynthesis
Authors: Harries C. I. , Smith D. M. , Gregg L. , Wittkowski A.
Published: February 2023

The consequences of Serious Mental Illness (SMI) on parent and child outcomes can be profound. Supporting parents to manage their caregiving roles alongside parental SMI successfully has been recognised as a public health priority. To meet this priority and develop effective and acceptable interventions, it is imperative that parents’ experiences and support needs are understood. This systematic review aimed to synthesise qualitative research that explored parents’ experiences and perceptions of the impact of SMI on their parenting and their corresponding support needs. The Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines were followed. Five databases were searched for terms associated with SMI, parenting, and qualitative research. Twenty-nine studies involving 562 parents who experienced SMI met inclusion criteria, and the methodological quality of included studies was appraised using the Critical Appraisal Skills Programme. After findings were synthesised using thematic synthesis, six themes were identified: (1) The constrained parent, (2) parenting difficulties, (3) the strained child, (4) inescapable threat, (5) combatting threat, and (6) wrap-around support needs. Novel insights into the centrality of SMI-related parenting difficulties and threat perceptions across parent, family, healthcare, and wider social systems on strained parent–child and distanced parent–support relationships were highlighted. Systemic practice change initiatives via compassionate and inclusive system-wide support were recommended.
Evolution of the characteristic curves in the restricted three-body problem in terms of the mass parameter
Authors: Abad A. , Arribas M. , Palacios M. , Elipe A.
Published: February 2023

In this work, we study the evolution of the families of simple symmetric periodic orbits in the restricted three-body problem whatever the value of the mass parameter $$\mu $$
μ
. To classify these characteristic curves, we introduce a topological characterization of both orbits and families. Starting from the work of Strömgren for the Copenhagen case, we analyze the evolution of these families, when the mass parameter $$\mu $$
μ
varies in (0, 1/2], focusing on their topological characterization, the existence of asymptotic points and the appearance of certain types of orbits such as horseshoe orbits. Lastly, we consider two samples, the Earth–Moon and Sun–Jupiter systems and classify the different types of orbits for these systems.
Label modification and bootstrapping for zero-shot cross-lingual hate speech detection
Authors: Bigoulaeva Irina , Hangya Viktor , Gurevych Iryna , Fraser Alexander
Published: February 2023

The goal of hate speech detection is to filter negative online content aiming at certain groups of people. Due to the easy accessibility and multilinguality of social media platforms, it is crucial to protect everyone which requires building hate speech detection systems for a wide range of languages. However, the available labeled hate speech datasets are limited, making it difficult to build systems for many languages. In this paper we focus on cross-lingual transfer learning to support hate speech detection in low-resource languages, while highlighting label issues across application scenarios, such as inconsistent label sets of corpora or differing hate speech definitions, which hinder the application of such methods. We leverage cross-lingual word embeddings to train our neural network systems on the source language and apply them to the target language, which lacks labeled examples, and show that good performance can be achieved. We then incorporate unlabeled target language data for further model improvements by bootstrapping labels using an ensemble of different model architectures. Furthermore, we investigate the issue of label imbalance in hate speech datasets, since the high ratio of non-hate examples compared to hate examples often leads to low model performance. We test simple data undersampling and oversampling techniques and show their effectiveness.
Sequential multilevel assimilation of inverted seismic data
Authors: Nezhadali Mohammad , Bhakta Tuhin , Fossum Kristian , Mannseth Trond
Published: February 2023

We consider estimation of absolute permeability from inverted seismic data. Large amounts of simultaneous data, such as inverted seismic data, enhance the negative effects of Monte Carlo errors in ensemble-based Data Assimilation (DA). Multilevel (ML) models consist of a selection of models with different fidelities. Multilevel Data Assimilation (MLDA) attempts to obtain a better statistical accuracy with a small sacrifice of the numerical accuracy. Spatial grid coarsening is one way of generating an ML model. It has been shown that coarsening the spatial grid results in a problem with weaker nonlinearity, and hence, in a less challenging problem than the problem on the original fine grid. Accordingly, formulating a sequential MLDA algorithm which uses the coarser models in the first steps of the DA, followed by the finer models, helps to find an approximation to the solution of the inverse problem at the first steps and gradually converge to the solution. We present two variants of a sequential MLDA algorithm and compare their performance with both conventional DA algorithms and a simultaneous (i.e., using all the models on the different grids simultaneously) MLDA algorithm using numerical experiments. Both posterior parameters and posterior model forecasts are compared qualitatively and quantitatively. The results from numerical experiments suggest that all MLDA algorithms generally perform better than the conventional DA algorithms. In estimation of the posterior parameter fields, the simultaneous MLDA algorithm and one of the variants of sequential MLDA (SMLES-H) perform similarly and slightly better than the other variant (SMLES-S). While in estimation of the posterior model forecasts, SMLES-S clearly performs better than both the simultaneous MLDA algorithm and SMLES-H.
On the rotation of melting ice disks
Authors: Schellenberg Louis M. , Newton Thomas J. , Hunt Gary R.
Published: February 2023

This investigation was inspired by the work of Dorbolo et al. (Phys Rev E 93(3):15, 2016), which was the first to study, at a laboratory scale, the phenomenon observed in the natural world of floating disks of ice rotating. They conclude that, in controlled conditions, ice disks are able to induce their own rotation. Whilst their work successfully exposes multiple aspects of the kinematics of such disks, and the buoyancy-driven flow generated beneath them as they melt, the mechanism by which rotation is triggered remains unsubstantiated. We therefore return in this work to the study of floating ice disks, focusing specifically on the importance of experimental technique in obtaining reliable measurements of disk behaviour. Our investigation reveals that the motion of ice disks placed on a nominally quiescent body of fresh water is unpredictable, with some disks remaining motionless, and others rotating clockwise or anticlockwise. For those in motion, the average rate of rotation observed was less than half of that recorded by Dorbolo et al., a discrepancy possibly explained by residual background motions in the nominally quiescent surrounding body of water. However, given our observation that non-melting disks of high-density polyethylene (HDPE) cooled to the same temperature as the ice (comparable HDPE and ice disks differing by only $$\sim 4$$

∼
4

% in mass) consistently rotated at rates less than those made of ice, it is hypothesised that, within the confines of the freshwater environment, the motion of the turbulent meltwater plume that forms beneath an ice disk amplifies the effect of residual background motions. From our observations, it is concluded that residual motions are an underlying physical trigger for disk rotation.
Accuracy of congenital anomaly coding in live birth children recorded in European health care databases, a EUROlinkCAT study
Authors: Bakker Marian K. , Loane Maria , Garne Ester , Ballardini Elisa , Cavero-Carbonell Clara , García Laura , Gissler Mika , Given Joanne , Heino Anna , Jamry-Dziurla Anna , Jordan Sue , Urhoj Stine Kjaer , Latos-Bieleńska Anna , Limb Elisabeth , Lutke Renee , Neville Amanda J. , Pierini Anna , Santoro Michele , Scanlon Ieuan , Tan Joachim , Wellesley Diana , de Walle Hermien E. K. , Morris Joan K.
Published: February 2023

Electronic health care databases are increasingly being used to investigate the epidemiology of congenital anomalies (CAs) although there are concerns about their accuracy. The EUROlinkCAT project linked data from eleven EUROCAT registries to electronic hospital databases. The coding of CAs in electronic hospital databases was compared to the (gold standard) codes in the EUROCAT registries. For birth years 2010–2014 all linked live birth CA cases and all children identified in the hospital databases with a CA code were analysed. Registries calculated sensitivity and Positive Predictive Value (PPV) for 17 selected CAs. Pooled estimates for sensitivity and PPV were then calculated for each anomaly using random effects meta-analyses. Most registries linked more than 85% of their cases to hospital data. Gastroschisis, cleft lip with or without cleft palate and Down syndrome were recorded in hospital databases with high accuracy (sensitivity and PPV ≥ 85%). Hypoplastic left heart syndrome, spina bifida, Hirschsprung’s disease, omphalocele and cleft palate showed high sensitivity (≥ 85%), but low or heterogeneous PPV, indicating that hospital data was complete but may contain false positives. The remaining anomaly subgroups in our study, showed low or heterogeneous sensitivity and PPV, indicating that the information in the hospital database was incomplete and of variable validity. Electronic health care databases cannot replace CA registries, although they can be used as an additional ascertainment source for CA registries. CA registries are still the most appropriate data source to study the epidemiology of CAs.
Epistemic Functions of Replicability in Experimental Sciences: Defending the Orthodox View
Authors: Sikorski Michał , Andreoletti Mattia
Published: February 2023

Replicability is widely regarded as one of the defining features of science and its pursuit is one of the main postulates of meta-research, a discipline emerging in response to the replicability crisis. At the same time, replicability is typically treated with caution by philosophers of science. In this paper, we reassess the value of replicability from an epistemic perspective. We defend the orthodox view, according to which replications are always epistemically useful, against the more prudent view that claims that it is useful in very limited circumstances. Additionally, we argue that we can learn more about the original experiment and the limits of the discovered effect from replications at different levels. We hold that replicability is a crucial feature of experimental results and scientists should continue to strive to secure it.
On cosmological low entropy after the Big Bang: universal expansion and nucleosynthesis
Authors: Sharpe Charlie F. , Barnes Luke A. , Lewis Geraint F.
Published: February 2023

We investigate the sensitivity of a universe’s nuclear entropy after Big Bang nucleosynthesis (BBN) to variations in both the baryon-to-photon ratio and the temporal evolution of cosmological expansion. Specifically, we construct counterfactual cosmologies to quantify the degree by which these two parameters must vary from those in our Universe before we observe a substantial change in the degree of fusion, and thus nuclear entropy, during BBN. We find that, while the post-BBN nuclear entropy is indeed linked to baryogenesis and the Universe’s expansion history, the requirement of leftover light elements does not place strong constraints on the properties of these two cosmological processes.
A study of Corchorus L. diversity in Egypt using high-throughput phenotyping platform (HTPP): an Egyptian gene bank example
Authors: Mahdy Ehab M. B. , Ahmad Hasan
Published: February 2023

Biodiversity and identification facilitate a prioritization of determination basis for plant evolutionary, phytogeography, biodiversity and conservation of plant genetic resources. High-throughput phenotyping platforms (HTPP) provide more attractive for genotyping for biodiversity evaluation. Descriptor lists include 51 attributes applied on all growth-stages of 53 C. olitorius accessions plus C. capsularis, C. trilocularis, C. tridens, and C. depressus. Three main groups were split. Variance decomposition was estimated within class of 68.87% and between classes of 31.13%. Major distance recorded 18.41 between class 1 (wild taxa only) and class three (18 accessions of C. olitorius). In contrast, the minor distance scored 8.3 between class 2 (35 accessions) and class 3 (18 accessions). Wild taxa with their rarity distribution and habitats prioritize highly conservation due to the association of evolutionary role and importance of genetic improvement. Conservation strategies applied to PGR prioritization are influenced by the distribution frequency and habitat specificity. The results are useful information on genetic diversity at the Egyptian Gene Bank, which could be used for C. olitorius genetic improvement programs and sustainable utilization.
No transport? No worries! Cardiac telerehabilitation is a feasible and effective alternative to centre-based programs
Authors: Hwang Rita , Gane Elise M. , Morris Norman R.
Published: February 2023

Given the under-utilisation of cardiac rehabilitation despite its benefits, there has been a shift towards alternative delivery models. The recent coronavirus disease 2019 (COVID-19) pandemic has accelerated this shift, leading to a growing interest in home-based cardiac rehabilitation including telerehabilitation. There is increasing evidence to support cardiac telerehabilitation, with studies generally demonstrating comparable outcomes and potential cost-benefits. This review aims to provide a synopsis of the current evidence on home-based cardiac rehabilitation with a focus on telerehabilitation and practical considerations.
Individual repeatability in the timing of river entry indicates the strong influence of photoperiod in the spawning migrations of iteroparous twaite shad Alosa fallax
Authors: Yeldham Mark I. A. , Britton J. Robert , Crundwell Charles , Davies Peter , Dodd Jamie R. , Nunn Andrew D. , Velterop Randolph , Bolland Jonathan D.
Published: February 2023

The timing of entry into freshwater by mature anadromous fishes is an important component of their migration phenology. In iteroparous anadromous species, identifying the migration cues that influence the timing of entry into freshwater, and annual variability in these timings, is important in assessing the extent of individual repeatability. Here, passive acoustic telemetry tracked 71 twaite shad Alosa fallax (‘shad’) returning to the River Severn’s upper estuary over successive spawning seasons, providing individual information on river entry timing and the associated migration cues. The timing of shad returning to the river (defined as their first detection on an acoustic receiver in the upper estuary) was consistent between years and strongly predicted by photoperiod (as increasing day length), whereas water temperatures and flow rates were weak predictors and highly variable between years. Timings of river entry of individual shad were also consistent across consecutive spawning migrations, indicating high individual repeatability. The application of acoustic telemetry in this study thus revealed high repeatability in the timing of annual spawning migrations, which were cued mainly by increasing day length and that, being seasonally predictable, should ensure entry into freshwater with sufficient time to arrive in spawning areas when in-river environmental conditions are favourable.
Enhancing ERP Responsiveness Through Big Data Technologies: An Empirical Investigation
Authors: Bandara Florie , Jayawickrama Uchitha , Subasinghage Maduka , Olan Femi , Alamoudi Hawazen , Alharthi Majed
Published: February 2023

Organizations are integrating big data technologies with Enterprise Resource Planning (ERP) systems with an aim to enhance ERP responsiveness (i.e., the ability of the ERP systems to react towards the large volumes of data). Yet, organizations are struggling to manage the integration between the ERP systems and big data technologies, leading to lack of ERP responsiveness. For example, it is difficult to manage large volumes of data collected through big data technologies and to identify and transform the collected data by filtering, aggregating and inferencing through the ERP systems. Building on this motivation, this research examined the factors leading to ERP responsiveness with a focus on big data technologies. The conceptual model which was developed through a systematic literature review was tested using Structural equation modelling (SEM) performed on the survey data collected from 110 industry experts. Our results suggested 12 factors (e.g., big data management and data contextualization) and their relationships which impact on ERP responsiveness. An understanding of the factors which impact on ERP responsiveness contributes to the literature on ERP and big data management as well as offers significant practical implications for ERP and big data management practice.
Heather (Calluna vulgaris) supports spider diversity of oligotrophic peat bogs
Authors: Urák István , Gallé-Szpisjak Nikolett , Szigyártó Irma-Lídia , Zsigmond Andreea-Rebeka , Gallé Róbert
Published: February 2023

The heterogeneity of microhabitats is an important driver of biodiversity. Therefore, conserving habitat heterogeneity at multiple spatial scales is essential to biodiversity conservation. This study investigates the effect and the conservation value of micromosaic heterogeneity provided by the heather (Calluna vulgaris) patches in an Eastern-European peat bog on the spider communities. We found that the heather patches strongly affect spiders; the species richness and abundance were higher in heather than in open bogs. Heather shrubs form a separate special microhabitat, which differs in structure, microclimate and litter quality, and has a significant positive effect on diversity of spiders. Furthermore, we collected smaller spiders and more web builders in heather sites than in control sites, presumably due to the different microhabitat structures and prey availability. However, habitat type did not affect the vertical microhabitat preference of spiders. The species composition of spider communities differed between the two microhabitat types. We identified seven significant indicator species in heather shrubs, whereas three species were significant indicators of control sites. The species richness and the presence of rare and endangered peat bog specialist spider species in heather patches highlight the high conservation value of peat bogs.
A Cohort Study on Deficiency of ADA2 from China
Authors: Li Guo-min , Han Xu , Wu Ye , Wang Wei , Tang Hong-xia , Lu Mei-ping , Tang Xue-mei , Lin Yi , Deng Fan , Yang Jun , Wang Xin-ning , Liu Cong-cong , Zheng Wen-jie , Wu Bing-bing , Zhou Fang , Luo Hong , Zhang Liang , Liu Hai-mei , Guan Wan-zhen , Wang Shi-hao , Tao Pan-feng , Jin Tai-jie , Fang Ran , Wu Yuan , Zhang Jie , Zhang Yao , Zhang Tian-nan , Yin Wei , Guo Li , Tang Wen-jing , Chang Hong , Zhang Qiu-ye , Li Xiao-zhong , Li Jian-guo , Zhou Zhi-xuan , Yang Si-rui , Yang Kang-kang , Xu Hong , Song Hong-mei , Deuitch Natalie T. , Lee Pui Y. , Zhou Qing , Sun Li
Published: February 2023

Purpose

Deficiency of adenosine deaminase 2 (DADA2), an autosomal recessive autoinflammatory disorder caused by biallelic loss-of-function variants in adenosine deaminase 2 (ADA2), has not been systemically investigated in Chinese population yet. We aim to further characterize DADA2 cases in China.

Methods

A retrospective analysis of patients with DADA2 identified through whole exome sequencing (WES) at seventeen rheumatology centers across China was conducted. Clinical characteristics, laboratory findings, genotype, and treatment response were analyzed.

Results

Thirty patients with DADA2 were enrolled between January 2015 and December 2021. Adenosine deaminase 2 enzymatic activity was low in all tested cases to confirm pathogenicity. Median age of disease presentation was 4.3 years and the median age at diagnosis was 7.8 years. All but one patient presented during childhood and two subjects died from complications of their disease. The patients most commonly presented with systemic inflammation (92.9%), vasculitis (86.7%), and hypogammaglobinemia (73.3%) while one patient presented with bone marrow failure (BMF) with variable cytopenia. Twenty-three (76.7%) patients were treated with TNF inhibitors (TNFi), while two (6.7%) underwent hematopoietic stem cell transplantation (HSCT). They all achieved clinical remission. A total of thirty-nine ADA2 causative variants were identified, six of which were novel.

Conclusion

To establish early diagnosis and improve clinical outcomes, genetic screening and/or testing of ADA2 enzymatic activity should be performed in patients with suspected clinical features. TNFi is considered as first line treatment for those with vascular phenotypes. HSCT may be beneficial for those with hematological disease or in those who are refractory to TNFi.
Contrast-enhanced transcranial doppler versus contrast transthoracic echocardiography for right-to-left shunt diagnosis
Authors: Tian Li , Zhang Min , Nie Hongjun , Zhang Guanling , Luo Xiaoyan , Yuan Huaiyun
Published: February 2023

RLS can be diagnosed using US, CT angiography, and right heart catheterization. However, most reliable diagnostic modality remains undetermined. c-TCD was more sensitive than c-TTE in the diagnosis of RLS. This was true especially for the detection of provoked shunts or mild shunts. c-TCD can be used as the preferred screening method for RLS.
Motive Satisfaction Among Patients with Chronic Primary Pain: A Replication
Authors: Scheidegger Alina , Goméz Penedo Juan Martín , Blättler Larissa Tatjana , Aybek Selma , Bischoff Nina , grosse Holtforth Martin
Published: February 2023

We set out to replicate findings of significant (a) reductions in pain, psychological distress, and motivational incongruence (i.e., insufficient motive satisfaction) after interdisciplinary multimodal pain treatment and (b) associations between reductions in motivational incongruence (i.e., improved motive satisfaction) and decreases in psychological distress (Vincent et al., Journal of Clinical Psychology in Medical Settings 28:331–343, 2021). 475 Patients with chronic primary pain completed standardized self-reported questionnaires assessing motivational incongruence, psychological distress, pain intensity, and pain interference at intake and discharge from a tertiary psychosomatic university clinic. We used hierarchical linear models to analyze motivational incongruence’s effects on psychological distress. We partially replicated Vincent et al.’s findings. Significant reductions in pain, psychological distress, and motivational incongruence after treatment were found. Reductions in motivational incongruence were associated with reductions in psychological distress. Similarly, a better motive satisfaction mediated the relationship between pain interference and psychological distress. Our findings show that reducing motivational incongruence may be a key component of treating chronic primary pain; we recommend to assess and target motivational incongruence to improve interdisciplinary multimodal pain treatment.
Post-heating Fluorescence-based Alteration and Adulteration Detection of Extra Virgin Olive Oil
Authors: Hamdy Omnia , Mohammed Haitham S.
Published: February 2023

Olive oils are more expensive compared with other vegetable oils. Therefore, adulterating such expensive oil is prevalent. The traditional methods for olive oil adulteration detection are complex and require pre-analysis sample preparation. Therefore, simple and precise alternative techniques are required. In the present study, the Laser-induced fluorescence (LIF) technique was implemented for detecting alteration and adulteration of olive oil mixed with sunflower or corn oil based on the post-heating emission characteristics. Diode-pumped solid-state laser (DPSS, λ = 405 nm) was employed for excitation and the fluorescence emission was detected via an optical fiber connected to a compact spectrometer. The obtained results revealed alterations in the recorded chlorophyll peak intensity due to olive oil heating and adulteration. The correlation of the experimental measurements was evaluated via partial least-squares regression (PLSR) with an R-squared value of 0.95. Moreover, the system performance was evaluated using receiver operating characteristics (ROC) with a maximum sensitivity of 93%.
Parallels in Practice: Applying Principles of Research Integrity and Ethics in Domestic Violence Fatality Review (DVFR)
Authors: Cook Elizabeth A. , Rowlands James , Bracewell Kelly , Jones Cassandra , Boughton Grace
Published: February 2023

Purpose

Within the context of the big data society, new systems of data collection on domestic violence and abuse (DVA) have emerged. One such system is Domestic Violence Fatality Review (DVFR) which captures the various dimensions of gender, violence, and abuse required to form an evidence base for prevention. However, to date, there has been limited dialogue between practitioners and researchers about the ‘doing’ of DVFRs.

Method

As DVFR systems vary by jurisdiction, we conducted a case study of Domestic Homicide Reviews (DHRs) in England and Wales. Applying the Research Integrity Framework (RIF) developed by the four Women’s Aid Federations in the United Kingdom (UK), this article examines both the practice of DHR and how it is utilised as data in research.

Results

Informed by our situated perspectives as researchers and/or practitioners working in the field, our analysis demonstrates how undertaking DHR as a practitioner parallels collecting, accessing, and analysing data from DHRs as a researcher. Guiding principles are identified to help practitioners and researchers navigate the parallel challenges they confront and, critically, inform dialogue between practice and research.

Conclusions

Implications for both professional practice and research are presented. To increase transparency and confidence, we argue that more attention should be afforded to the methodological and ethical issues inherent in both the practice of DHRs, and their utilisation as a source of data in research. While DHRs have differences to DVFRs in other jurisdictions, these findings also have implications for these other systems which will also be discussed.