bluuebunny/crossref_metadata_2025 huggingface dataset:
Оксидативний стрес – негативний наслідок екзогенного впливу на організм спортсменів
Authors: Чернікова Ольга , Осадча Оксана , Шматова Олена , Барчук Марина
Published: June 2024

Резюме. Робота присвячена актуалізації питання окиснювального стресу та дії антиоксидантів у практиці спортивної підготовки. Визначено, що під час фізичної активності зростає потреба в кисні, особливо в скелетних м’язах, внаслідок чого відбувається різка зміна кровопостачання до різних органів. Визначені фізіологічні зміни збільшують вироблення вільних радикалів, викликаючи окиснювальне пошкодження біомолекул. Мета. Визначити наукові підходи у питанні окиснювального стресу та дії антиоксидантів у практиці спортивної підготовки. Методи. Аналіз і узагальнення даних спеціальної науково-методичної літератури; моніторинг інформаційних ресурсів мережі Інтернет; метод систематизації; контент-аналіз. Результати. Встановлено, що основними науковими напрями дослідження виникнення оксидативного стресу та протидії йому є складання дієтичних програм на основі споживання різних комбінацій антиоксидантів, а також розробка технологій тренувальних занять зі зменшенням рівня розвитку та прояву оксидативного стресу через підібраний індивідуальний режим, спрямованість та обсяг фізичних навантажень. Проте нами виокремлено тези, які можуть визначити зміст гіпотези подальших досліджень: більшість робіт, які інформують про користь антиоксидантних добавок для зменшення пошкодження м’язів та протидії окиснювальному стресу після тренувальних занять на витривалість, були проведені на здорових, але нетренованих особах. У тренованих людей ендогенний антиоксидантний захист може бути підвищеним, тобто кращим, і екзогенні антиоксидантні добавки для зменшення пошкодження м’язів можуть не мати значного ефекту дії на організм. Результати систематизації отриманих у ході аналізу даних науково-методичної літератури та моніторингу інформаційних джерел мережі Інтернет показали, що фізичні навантаження викликають окиснювальний стрес через утворення вільних радикалів та зниження рівня антиоксидантних ферментів у різних тканинах і органах. Проте, залежно від інтенсивності та обсягу навантаження в організмі розвивається різний ступінь окиснювального стресу: утворення вільних радикалів зростає зі збільшенням споживання кисню та окисного фосфорилювання.
Ключові слова: оксидативний стрес, спортсмени, антиоксиданти, окиснення, перенавантаження.
The State of Paediatric Dialysis: Is the Story Different at Federal Medical Center, Asaba, South-South Nigeria?
Authors: Ezeonwu Bertilla U , Ajaegbu Obinna C , Joseph Uzoma C Ajanwenyi , Achuzia Blessing E , Ajanwenyi Joseph N , Osim Chinemerem , Origbo Lazarus C , Onwuli Rachael E
Published: June 2024

Introduction: Dialysis is a type of renal replacement therapy (RRT) employed to maintain the excretory function of a failed kidney. Hemodialysis is the most common form of dialysis offered worldwide and in Nigeria and in this analysis, we compared our experiences with previously published studies on pediatric dialysis. Method: A retrospective observational case series study of a prospective clinical database of children admitted into the pediatric ward of Federal Medical Center, Asaba, South-South Nigeria, who accessed hemodialysis during their management in the Pediatric nephrology unit, from November 2016 to October 2022 (6 years). Results: There were 78 patients admitted and managed by the nephrology unit during the study period, 37.2% required RRT, and 69.0% accessed it of which 55% were females, 80% were adolescents, and 55% with Acute Kidney Injury (AKI). The median age at initiation of RRT was 12 years. Patients requiring hemodialysis (HD) for AKI were majorly those with nephrotic syndrome while most of those with chronic kidney disease (CKD) were of unknown etiology. All patients had multiple indications for HD but the most frequent was anuria. Patients with AKI were younger and pericardial effusion was a more common indication for HD in patients with CKD. The inpatient case fatality rate was 25% but the total including during the follow-up period was 50%. The presence of encephalopathy as an indication of HD was associated with an increased case fatality rate. Conclusion: Our RRT experience was comparable to other published works. The findings from this analysis underscore the need for nephro-prevention at all levels, as RRT is largely inaccessible and with fatal outcomes in our environment.
DESAIN PENGEMBANGAN KURIKULUM PENDIDIKAN AGAMA ISLAM TERPUSAT PADA MASALAH
Authors: Hayati Lutfi Nur
Published: June 2024

Dalam upaya mencetak generasi yang berkualitas baik dari segi akademis maupun moralitasnya, kurikulum perlu didesain dan dikembangkan sesuai dengan kondisi atau permasalahan yang dihadapi peserta didik dalam lingkungannya. Penelitian ini bertujuan untuk mengeksplorasi terkait desain pengembangan kurikulum pendidikan agama Islam yang berfokus pada masalah-masalah yang relevan. Pilihan ini menarik karena didasarkan pada asumsi bahwa manusia sebagai makhluk sosial pasti dihadapkan pada persoalan dalam kehidupan yang memerlukan solusi bersama untuk diselesaikan. Penelitian ini menggunakan metode studi kepustakaan atau library research, dengan mempelajari berbagai artikel, buku, prosiding, dan penelitian yang relevan dengan topik penelitian sebagai referensi. Hasil dari penelitian ini menunjukkan bahwa desain pengembangan kurikulum yang terpusat pada masalah dapat meningkatkan kemampuan berpikir kritis, keterampilan sosial, kepercayaan diri, dan hasil belajar siswa dalam memahami serta menyelesaikan masalah-masalah sosial dalam masyarakat yang berkaitan dengan pendidikan nilai-nilai keIslaman. Oleh karena itu, para pendidik perlu mengembangkan desain kurikulum yang terpusat pada masalah dalam pembelajaran pendidikan agama Islam. Tujuan dari desain ini adalah agar pembelajaran menjadi lebih mudah dipahami oleh siswa karena erat kaitannya dengan kehidupan yang mereka alami di lingkungan sekolah dan masyarakat.
MODEL PEMBELAJARAN TAHFIDZUL QUR’AN DENGAN INTERNALISASI NILAI NEUROSAINS
Authors: MAHDI IMAM
Published: June 2024

model pembelajaran tafidzul qur’an saat ini menjadi sorotan ilmuan pendidikan era saat ini, melihat capaian dan proses model tahfidzul qur’an hanya pada hafalan, di era sekarang kebutuhan siswa harus mencapai kritis, inovasi, serta kreatif untuk menghadapi masalah kehidupan. Maka dengan adanya penelitian ini memberikan nilai neurosains dalam model pembelajaran thafidzul qur’an untuk mengoptimalkan seluruh sel otak siswa. Penggunaan penelitian yaitu dengan library reseach dalam mengumpulkan literatur pada buku, jurnal, dan media informasi lainya, Tahapan analisis mendalam dimulai mengumpulkan literatur, menselektif, menganalisis atau perbandingan, dan menarik kesimpulan.
Hasil dari tawaran nilai neurosains dalam pembelajaran tahfidzul qur’an memberikan siklus baru dalam proses pembelajaran sehingga siswa mencapai memori yang jangka panjang, melalui tahapan proses pembelajaran basis neurosains dalam memudahkan siswa dalam mengahfal al-qur’an dan hadist
PENGEMBANGAN E-COMIC BERBASIS AI “PETINJU” (PETUALANGAN TINO JUJUR) TENTANG MATERI PERILAKU TERPUJI PADA PEMBELAJARAN PAI KELAS 3 SD
Authors: Andini Wanda Sri , Septiani Putri , Sarti Sarti , Aeni Ani Nur
Published: June 2024

Penelitian ini bertujuan untuk mengembangkan e-comic berbasis AI untuk pembelajaran Pendidikan Agama Islam (PAI) dengan fokus pada materi perilaku terpuji. Selain itu, e-comic juga bertujuan untuk menyampaikan pesan kunci tentang pentingnya kejujuran dalam kehidupan sehari-hari. Metode penelitian yang digunakan adalah metode Design and Development (D&D) dengan desain pengembangan menggunakan model ADDIE yang dirancang untuk memberikan pengalaman pembelajaran interaktif serta menyenangkan kepada siswa dengan memanfaatkan teknologi AI. Setelah pengembangan, e-comic dapat di evaluasi melalui uji coba lapangan. Hasil evaluasi menunjukkan bahwa e-comic dapat efektif dalam meningkatkan pemahaman siswa terhadap materi perilaku terpuji dalam PAI. Implikasi penelitian ini adalah memberikan kontribusi pada pengembangan berbasis teknologi untuk mendukung pembelajaran PAI yang lebih interaktif dan menarik.
HAKIKAT PSIKOLOGI SEBAGAI LANDASAN DALAM PEMBELAJARAN PAI
Authors: Nurnaesih Nurnaesih , Muslihah Eneng , Kultsum Umi
Published: June 2024

Tujuan dari penelitian ini ialah menganalisis hakikat psikologi sebagai landasan pada pembelajaran PAI. Pada pelaksanaannya, peneliti menggunakan metode kualitatif berjenis studi kepustakaan, yang mana memakai data sekunder sebagai sumber data. Hasil penelitian ini diketahui bahwasanya landasan pendidikan agama Islam yang sangat dibutuhkan di Indonesia adalah psikologi. Psikologi dapat memberikan acuan kepada orang tua maupun guru dalam mendidik anak sesuai dengan tingkat perkembangan psikologi anak. Dalam hakikatnya, psikologi sebagai landasan pembelajaran pendidikan agama Islam memiliki peran penting sebagai upaya menanamkan kesadaran keagamaan yang berkaitan dengan nilai bathiniyah anak guna mengembangkan potensi dalam dirinya. Dimana landasan psikologi tersebut berimplikasi pada psikologi perkembangan, belajar, dan sosial. Sehingga dapat membentuk anak menjadi manusia unggul, berkarakter Islami, dan dapat diterima dalam kelompok atau masyarakat.
DIGITAL TRANSFORMATION ОF BUSINESS IN THE CONTEXT OF WAR IN UKRAINE: CHALLENGES AND OPPORTUNITIES
Authors:   Hryhoriy Skovoroda University in Pereiaslav, Yevtushenko Nataliia , Stetsenko Dmytro ,   Hryhoriy Skovoroda University in Pereiaslav
Published: June 2024

The development of the digital economy is changing all aspects of the economic environment. Businesses are undergoing a transformation in the size, ways of doing business and interaction with key economic structures. This is leading to a rethinking of the main tasks of business administration and management under the influence of digital technologies. These technologies, based on the capabilities of the Internet, form digital platforms for business, where it is possible to conduct transactions, collect data, select and compare counterparties, and conduct financial transactions. Current realities also reinforce the need for digital transformation of domestic business. The article considers the relevance of digital transformation of Ukrainian business in the context of numerous challenges caused by the war in Ukraine. The article analyses the innovative opportunities offered by digital transformation for the development of enterprises. It is noted that the introduction of advanced technologies, such as Big Data or artificial intelligence (AI), allows optimising the management process, analysing data to make operational decisions, providing individual offers to customers and forecasting the market dynamics of the enterprise. The study also emphasises that in the context of the war, the European Innovation Council has provided €20 million in support for the development of innovations in Ukraine to improve the digital transformation of Ukrainian businesses. The article emphasises the benefits of digital transformation for domestic business and identifies that in 2022 there was a decline in the digital transformation of Ukrainian business due to the impact of the Russian-Ukrainian war. Supporting businesses during the military conflict is becoming an important task, but its implementation is complicated by disruptions in production and logistics chains, constant shelling, and internal migration. Despite all these difficulties, various projects have been developed for entrepreneurs to improve the digital transformation of domestic businesses under martial law. Further research is planned to focus on the main aspects of the digital transformation of business processes in the context of war and post-conflict recovery in Ukraine.
The Politics of Indigenous Representation In American and Canadian Physique Photography of the 1950s and 1960s
Authors: Wall Gillian
Published: June 2024

This thesis examines the racial, social and gender politics present in the Indigenous representation of the golden era of Physique photography during the 1950s and 1960s. It explores themes such as: the romanticization and sexualization of Indigenous men, links between Indigenous imagery and homoerotic imagery in Physique photography, what it means to "play Indian," and, the semiotic relationship between cowboys and "Indians." This collection of photographs originates primarily from Western Physique magazines of the 1950s and 1960s and is taken from the Thomas Waugh Collection, which is housed within the Sexual Representations Collection at the Mark S. Bonham Centre for Sexual Diversity Studies, TheArQuives - Canada's LGBTQ2+Archives and The Gale Database Archives of Sexuality and Gender.
Parental Engagement in Supporting Children with Learning Difficulties
Authors: Ybañez Yacinth , Ponce Jennifer , Recaña Jeorgen , Cañete Janine Joy , Opingo Kaitlin Marie , Mangubat Randy
Published: June 2024

Parental engagement creates a pleasant learning environment, increases learners' confidence, motivation, and academic achievement with learning issues, and offers critical support and encouragement. This study assessed the parental engagement of the Grade 5 learners with learning difficulties in the three public elementary schools in Cebu, Philippines, during the school year 2023-2024 as the basis for the intervention plan. This study employed the descriptive-correlational method of research using the survey questionnaire as the principal instrument in gathering the needed data regarding the parental engagement of Grade 5 learners with learning difficulties. The study's respondents are 217 parents of Grade 5 learners of the three public elementary schools. This study utilized an adapted survey questionnaire from Azubuike and Aina (2017) to gather information regarding the parental engagement of Grade 5 learners with learning difficulties. The collected data were treated using frequency, simple percentage, mean, standard deviation, and Chi-square test of independence. The study revealed that the level of parental engagement and the challenges of the learners with learning difficulties, as observed by the parents, do not correlate with its profile. It was determined that a strong relationship between parents and teachers is necessary to establish a supportive learning environment that considers the particular requirements of these pupils. Engaging parents in their child's education helps to develop a feeling of teamwork and shared accountability. The researchers recommend implementing, monitoring, and evaluating the intervention plan to improve parents' engagement with children with learning difficulties.
Issues of Gender in the First-Grade IT Textbook in Oman
Authors: Bataineh Adnan , Douzandeh Ebrahim , Al Shidi Amna
Published: June 2024

The objective of this study is to conduct an analysis of gender representation within the Information Technology (IT) school textbook utilized in Grade 1 across all public schools in Oman. The investigation of categories such as images, names, and gender firstness is commonly conducted using quantitative and qualitative content analysis. The study findings indicate that the IT school textbook utilized in Grade 1 demonstrates gender balance and equality. The textbook exhibited a nearly equal representation of males and females, both in terms of quantity and quality. The outcomes of the study also indicate that females exhibited greater visibility compared to males in the areas pertaining to images, names, and gender precedence in terms of speaking order. On the other hand, males exhibited a higher level of visibility within the gender-firstness category, which pertains to the order in which individuals are depicted in images.  Overall, the school textbook demonstrated an equitable and unbiased portrayal of both genders. The results of the current investigation are expected to serve as a catalyst for authors to generate educational materials that exhibit a more equitable representation of genders within the school curriculum.
Oxidative Stress Adverse Effects in Histological Changes Induced by Anticancer Drugs: A Review Article
Authors: Dalia Amer khudhair  , Zainab Hayder Jaber Alkufaishi  , Teeb M. Jaafar Al-khafaji
Published: June 2024

The imbalance in oxidant burden is defined as oxidative stress (OS), which is the most significant event in the body involved in cancer development and progression. Cancer cells are characterized by high levels of OS and higher oxidant levels. That makes a physician use a double medication strategy to regulate redox status, like pro-oxidant medication and antioxidant supplements. In fact, pro-oxidant drugs have high anti-cancer activities regarding great oxidant levels within cancer cells, while antioxidant medication for redox homeostasis was a failure in some clinical trials. In cancer cells, the redox vulnerability targeted by pro-oxidants ability to produce high-level reactive oxygen species (ROS) is essential for an anti-cancer strategy. Nevertheless, numerous harmful impacts happened by the random targets of uncontrolled therapy stimulate OS in the normal tissues, and the capacity of drug-tolerant of several cancer cells greatly restricted their more implements. The effect of ROS in tissues is revealed by protein oxidation, lipids peroxidation, and DNA mutation; all these changes contribute to histological changes. In the present review, some representative oxidative anti-cancer medications and adverse effects were explained.
Social Messaging Application with Translation and Speech-to-Text Transformation
Authors: Yip Kang Qin , Goh Pey Yun , Chong Lee Ying
Published: June 2024

Unlike traditional SMS or MMS, messaging apps offer a broader range of data transmission capabilities. The application utilizes a WIFI or internet connection and enables users to exchange information through various means such as text, voice, and multimedia files. However, popular messaging applications such as WeChat, Telegram, and WhatsApp have limitations in language translation and file uploading size. Thus, this project aims to address these limitations by developing a social messaging application that serves as a comprehensive communication tool. The application will facilitate both written and verbal communication by providing translation services for various languages, including voice messages. The proposed application intends to act as a versatile platform, functioning as a translator while enabling seamless communication between users in different languages. Translation accuracy and BLEU metric are applied to evaluate the efficacy of the enhanced social messaging application. The proposed application is able to translate voice and written messages into another language with the help of Google translation API as well as Speech to text API. The BLEU average score between English and Malay is 0.94 but the translation between Malay and Chinese is 0.82, Chinese and English is 0.70. Though not perfect, the proposed application can enhance the current social messaging application with the speech-to-text feature and message translation feature. Last but not least, a concluding remark is provided to further improve the application in future.
Editorial Preview
Authors: Haw Su-Cheng
Published: June 2024

This editorial highlights all 18 papers in the June issue that deal with the practical aspects of Machine Learning (ML), Artificial Intelligence (AI), Data Mining (DM), the Internet of Things (IoT), Computer Vision, e-learning, and other topics in Computer Science. This issue also includes suggestions for several worthwhile works that deserve further research. With effective from our third volume first issue, we will be publishing triannually in February, June and October.
Streamlining Dental Clinic Management for Effective Digitisation Productivity and Usability
Authors: Ho Sin-Ban , Chew En-Yu , Tan Chuie-Hong
Published: June 2024

Oral health is an integral part of overall health, and poor oral hygiene can lead to a variety of health problems. Modern oral care has greatly improved our quality of life, but the increasing demand for routine dental checkups and treatments calls for improved systems for managing patient records and appointments. While technology has significantly enhanced the efficacy and experience of dental care, many dental clinics still rely on paper records to record the patient’s oral condition, but these are not easily accessible to the patients for viewing. This study aims to address the issue by developing a Dental Clinic Management System to manage patient appointments and records. This system will allow patients to manage their appointments, view their dental history, and receive comments from dentists. Dentists will be able to view appointments, perform treatments, and provide feedback to patients, while the administrator or receptionist will be able to manage appointments, view records, and create invoices. By streamlining dental clinic management, this system aims to improve the overall quality of oral healthcare.
Ensemble-SMOTE: Mitigating Class Imbalance in Graduate on Time Detection
Authors: Law Theng-Jia , Ting Choo-Yee , Ng Hu , Goh Hui-Ngo , Quek Albert
Published: June 2024

In education, detecting students graduating on time is difficult due to high data complexity. Researchers have employed various approaches in identifying on-time graduation with Machine Learning, but it remains a challenging task due to the class imbalance in the dataset. This study has aimed to (i) compare various class imbalance treatment methods with different sampling ratios, (ii) propose an ensemble class imbalance treatment method in mitigating the problem of class imbalance, and (iii) develop and evaluate predictive models in identifying the likelihood of students graduating on time during their studies in university. The dataset is collected from 4007 graduates of a university from year 2021 and 2022 with 41 variables. After feature selection, various class imbalance treatment methods were compared with different sampling ratios ranging from 50% to 90%. Moreover, Ensemble-SMOTE is proposed to aggregate the dataset generated by Synthetic Minority Oversampling Technique variants in mitigating the problem of class imbalance effectively. The dataset generated by class imbalance treatment methods were used as the input of the predictive models in detecting on-time graduation. The predictive models were evaluated based on accuracy, precision, recall, F0.5-score, F1-score, F2-score, Area under the Curve, and Area Under the Precision-Recall Curve. Based on the findings, Logistic Regression with Ensemble-SMOTE outperformed other predictive models, and class imbalance treatment methods by achieving the highest average accuracy (87.24), recall (92.50%), F1-score (91.30%), and F2-score (92.02%) from 6th until 10th trimester. To assess the effectiveness of class imbalance treatment methods, Friedman test is performed to determine on significant difference between the models after applying Shapiro-Wilk test in normality test. Consequently, Ensemble-SMOTE is ranked as the top-performers by achieving the lowest value in the average rank based on the performance metrics. Additional research could incorporate and examine more complicated approaches in mitigating class imbalance when the dataset is highly imbalanced.
The impact of policing and homelessness on violence experienced by women who sell sex in London: a modelling study
Authors: Grenfell Pippa , Elmes Jocelyn , Stuart Rachel , Eastham Janet , Walker Josephine , Browne Chrissy , Henham Carolyn , Blanco M Paz Hernandez , Hill Kathleen , Rutsito Sibongile , O’Neill Maggie , Sarker MD , Creighton Sarah , Vickerman Peter , Boily Marie-Claude , Platt Lucy
Published: June 2024

Street-based sex workers experience considerable homelessness, drug use and police enforcement, making them vulnerable to violence from clients and other perpetrators. We used a deterministic compartmental model of street-based sex workers in London to estimate whether displacement by police and unstable housing/homelessness increases client violence. The model was parameterized and calibrated using data from a cohort study of sex workers, to the baseline percentage homeless (64%), experiencing recent client violence (72%), or recent displacement (78%), and the odds ratios of experiencing violence if homeless (1.97, 95% confidence interval 0.88–4.43) or displaced (4.79, 1.99–12.11), or of experiencing displacement if homeless (3.60, 1.59–8.17). Ending homelessness and police displacement reduces violence by 67% (95% credible interval 53–81%). The effects are non-linear; halving the rate of policing or becoming homeless reduces violence by 5.7% (3.5–10.3%) or 6.7% (3.7–10.2%), respectively. Modelled interventions have small impact with violence reducing by: 5.1% (2.1–11.4%) if the rate of becoming housed increases from 1.4 to 3.2 per person-year (Housing First initiative); 3.9% (2.4–6.9%) if the rate of policing reduces by 39% (level if recent increases had not occurred); and 10.2% (5.9–19.6%) in combination. Violence reduces by 26.5% (22.6–28.2%) if half of housed sex workers transition to indoor sex work. If homelessness decreased and policing increased as occurred during the COVID-19 pandemic in 2020, the impact on violence is negligible, decreasing by 0.7% (8.7% decrease-4.1% increase). Increasing housing and reducing policing among street-based sex workers could substantially reduce violence, but large changes are needed.
Spectroscopic Confirmation of an Ultra-Massive Galaxy in a Protocluster at z ∼ 4.9
Authors: Urbano Stawinski Stephanie M. , Cooper M. C. , Forrest Ben , Muzzin Adam , Marchesini Danilo , Wilson Gillian , Gomez Percy , McConachie Ian , Marsan Z. Cemile , Annuziatella Marianna , Chang Wenjun
Published: June 2024

We present spectroscopic confirmation of an ultra-massive galaxy (UMG) with log(M⋆/M⊙)=10.98±0.07 at zspec=4.8947 in the Extended Groth Strip (EGS), based on deep observations of Ly α emission with Keck/DEIMOS. The ultra-massive galaxy (UMG-28740) is the most massive member in one of the most significant overdensities in the EGS, with four additional photometric members with log(M⋆/M⊙)>10.5 within Rproj∼1 cMpc. Spectral energy distribution (SED) fitting using a large suite of star formation histories and two sets of high-quality photometry from ground- and space-based facilities consistently estimates the mass of this object to be log(M⋆/M⊙)∼11 with a small standard deviation between measurements ( σ=0.07). While the best-fit SED models agree on stellar mass, we find discrepancies in the estimated star formation rate for UMG-28740, resulting in either a star-forming or quiescent system. 𝐽𝑊𝑆𝑇/NIRCam photometry of UMG-28740 strongly favors a quiescent scenario, demonstrating the need for high-quality mid-IR observations. Assuming the galaxy to be quiescent, UMG-28740 formed the bulk of its stars at z>10 and is quenching at z∼8, resulting in a high star formation efficiency at high redshift ( ϵ∼0.2 at z∼5 and ϵ≳1 at z≳8). As the most massive galaxy in its protocluster environment, UMG-28740 is a unique example of the impossibly early galaxy problem.
Influência da espiritualidade em pacientes adultos diagnosticados com câncer e submetidos a tratamentos oncológicos
Authors: Neves Beatriz Miranda das , Pinho Lilian Marcela Santana , Silva Camila Pain da , Couto Lima Carlos Antonio
Published: June 2024

São crescentes as buscas sobre a influência que a espiritualidade exerce na vida de pacientes em tratamento oncológico, visto que esta é uma dimensão importante da vida do ser humano, auxiliando-o na busca pelo sagrado, ajudando-o frente ao prognóstico e aumentando sua qualidade de vida. Este estudo objetiva identificar as reais influências do fortalecimento e apoio espiritual aos pacientes adultos diagnosticados com câncer e submetidos a    tratamentos oncológicos, presentes em literatura, de forma que possamos reconhecê-las integralmente oportunizando que o cuidado e assistência a estes indivíduos sejam progressivamente mais individualizados. Trata-se de uma revisão sistemática da literatura sobre a influência da espiritualidade em pacientes adultos e submetidos a tratamentos oncológicos, nas bases de dados LILACS, MEDLINE e PubMed nos idiomas português e inglês, que buscou artigos entre os anos de 2016 e 2021. Com os resultados obtidos, foram selecionados treze trabalhos que apresentavam aspectos relevantes para a discussão desta revisão, destes artigos a maioria trazia a correlação da espiritualidade com a aceitação do prognóstico e qualidade de vida, e apenas um trabalho convergiu com essas afirmações. Desta forma identifica-se a influência da espiritualidade no processo biopsicossocial de paciente diagnosticado com câncer, contribuindo para o enfrentamento da doença e considera-se importante a compreensão sobre o tema principalmente para profissionais na área da saúde, em especial a equipe de enfermagem, visto que, empregam o cuidado direto e contínuo ao paciente.
A atuação do enfermeiro na promoção do aleitamento materno exclusivo na Atenção Básica
Authors: Dantas Kmtlem de Souza Barbosa
Published: June 2024

O Aleitamento Materno Exclusivo – AME, quando a criança nos seis primeiros meses de vida, só tem como fonte de nutrição o leite materno, seja esse leite introduzido diretamente da mama ou ordenhado, sem precisar adicionar qualquer substância líquida ou sólida como complemento nutricional, o aleitamento materno, promovem proteção imunológica para a criança como anticorpos, enzimas e células brancas sanguíneas, sendo que, o leite materno possui propriedades nutricionais capaz de nitrir o bebê sem precisar de utilizar nenhum composto alimentar complementar. Objetivo: Descrever a atuação do profissional da Enfermagem como orientador e incentivador das práticas de aleitamento materno na atenção básica. Metodologia: o estudo apresenta uma Revisão Narrativa de Literatura de abordagem descritiva. Coleta na base de dados da Revista Research, Society and Development – RSD, Scielo e BVS. Resultados: análise de seleção de publicações, categorizou-se os estudos no quadro1, com identificação dos tópicos número, autor e data, título da publicação e os objetivos dos estudos. Os resultados encontrados, foram 15 publicações sobre consulta na base de dados. Considerações finais: o profissional da saúde é a peça-chave para orientar a mãe no processo de amamentação, com apoio as dificuldades que possam ser geradas nessa nova fase por meio de estratégias de abordagens e intervenções eficazes nas consultas de enfermagem.
Anatomia do esqueleto apendicular de cães e as principais malformações nos membros
Authors: Mothé Gabriele Barros , Felipe Kaiane Amorim Gonçalves , Gomes Maria Eduarda Ferreira de Carvalho , Araujo Daniella Paes de , Santos Rebecca Souza dos , Rasga Caroline de Lima , Sá Christiane Corrêa de , Palomino Julia Alves , Fonseca Adriana Trindade , Mendes Junior Aguinaldo Francisco
Published: June 2024

Os membros dos cães, divididos em torácicos e pélvicos, são essenciais para a sustentação, locomoção e absorção de impacto, cada um composto por ossos específicos como escápula, úmero, rádio, ulna, fêmur, tíbia e fíbula. As malformações ósseas apendiculares em cães são um grupo de condições que afetam o desenvolvimento normal do esqueleto, podendo levar a uma série de problemas de saúde e bem-estar para esses animais. Baseado nisso, este trabalho tem o objetivo de descrever a anatomia do esqueleto apendicular canino e compará-la com as alterações anatômicas encontradas nas principais malformações, bem como suas implicações clínicas, por meio de uma revisão da literatura. Essas alterações podem ser congênitas, ou seja, presentes desde o nascimento, ou adquiridas ao longo da vida do animal devido a fatores ambientais, nutricionais ou traumáticos. Dentre as malformações ósseas mais comuns nos membros de cães, destacam-se a displasia coxofemoral, a displasia do cotovelo e a luxação patelar. A displasia coxofemoral é caracterizada por uma malformação da articulação do quadril, resultando em instabilidade e dor, podendo levar à osteoartrite secundária. Já a displasia do cotovelo envolve alterações nas articulações úmero-rádio-ulnar, causando claudicação e desconforto. Por sua vez, a luxação patelar é uma condição em que a patela se desloca do sulco troclear do fêmur, causando dor e claudicação. Sendo assim, a identificação precoce das malformações é crucial para o manejo adequado e para a implementação de intervenções terapêuticas que possam melhorar a função e a qualidade de vida dos pacientes.
O impacto da pornografia online na saúde dos adolescentes
Authors: Assis Diana Cavalcante Miranda de
Published: June 2024

O presente artigo explora os múltiplos impactos do consumo de pornografia online nos adolescentes, dividindo a análise em três principais áreas de impacto: cerebral, psicológico e comportamental/social. Fundamentado em uma revisão bibliográfica narrativa de publicações dos últimos cinco anos, seguindo a metodologia de Green, Johnson e Adams (2006), a análise integrativa e qualitativa abrangeu estudos recentes sobre o tema. A exposição frequente à pornografia está associada a ansiedade, depressão, baixa autoestima e comportamentos sexuais de risco. A pornografia ativa a via de recompensa do cérebro, levando à dessensibilização e possível dependência. Socialmente, perpetua normas de gênero problemáticas e dificulta o desenvolvimento de habilidades de intimidade. As considerações finais ressaltam a necessidade de estratégias educacionais e políticas públicas que promovam uma sexualidade saudável e relações interpessoais positivas. É essencial que educadores, pais e profissionais de saúde abordem essas questões de maneira informada, assegurando um ambiente seguro para o desenvolvimento dos adolescentes.
Produto Educacional: a avaliação de um site como plataforma de educação ambiental, divulgação e articulação social
Authors: Trajano Sílvia Cristina de Souza , Médice Júnior Fábio , Cardoso Giovana da Silva , Medeiros Letícia Piedade de , Nascimento Patrícia Maria Pereira do , Lima Valéria da Silva , Bomfim Alexandre Maia do
Published: June 2024

Este artigo é a segunda parte da avaliação realizada por cursistas da especialização em docência ao site desenvolvido como Produto Educacional (PE) do doutorado profissional em ensino de ciências do Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro (IFRJ) em 2024, compondo parte do livro: Práticas Pedagógicas - Abordagens e Metodologias Inovadoras, pela editora Inovar. O presente recorte é uma complementação não apresentada no livro. Visto que, a primeira parte foi dedicada a análise dos dados quantitativos da tese e, para o presente artigo, daremos atenção aos dados qualitativos, com o objetivo de apresentar resultados da avaliação discursiva, dos primeiros avaliadores do site como Produto Educacional. Como metodologia, utilizamos uma breve descrição dos dados discursivos, onde dispomos das narrativas desses avaliadores, em suas percepções sobre o site, dados resultantes do questionário elaborado no google forms e aplicado como tarefa não pontuada, na disciplina em Gestão em Educação Profissional Técnica (Gestão em EPT) no curso de especialização em Docência para a Educação profissional Tecnológica - DocEPT. Os referenciais teóricos que nos embasam são Hernández e Ventura; Saviani; Zanotto e Rose; Guimarães; Freire e Morin; Almeida e Grubisich; Anjos, Rôças; Pereira, autores da área de ensino; currículo e projetos, direcionando-nos para as análises e discussão.
O emergente uso do Ozempic® no tratamento da obesidade
Authors: Maria Evelyn de Oliveira de , Pereira Loren Stefani Santos , Felacio Miriã da Silva , Shillo Remaz Sameh Ibrahim
Published: June 2024

O estudo "O Emergente Uso do Ozempic® no Tratamento da Obesidade" analisa a eficácia e segurança da semaglutida (Ozempic®), originalmente aprovada para diabetes tipo 2, no tratamento da obesidade. O objetivo é revisar estudos clínicos para informar a prática clínica sobre os benefícios do medicamento para perda de peso. A metodologia inclui a revisão de estudos dos programas SUSTAIN e STEP, que investigaram a semaglutida em diferentes populações, incluindo pessoas com e sem diabetes tipo 2. Os estudos SUSTAIN demonstraram reduções significativas na glicose sanguínea e na hemoglobina HbA1c, além de um perfil de segurança favorável. O programa STEP mostrou que a semaglutida resultou em uma perda média de peso entre 14,9% e 17,4% após 68 semanas de tratamento. A conclusão destaca que a semaglutida não só promove perda de peso significativa, mas também melhora parâmetros de saúde, como controle glicêmico, prevenção de eventos cardíacos como derrame e AVC em pessoas com doenças cardiovasculares e perfil lipídico, sendo uma opção promissora no manejo da obesidade. A supervisão médica é essencial, dada a necessidade de monitoramento dos efeitos colaterais e ajustes de dosagem.
Produksi personal care product berbasis atsiri untuk peningkatan kemandirian santri
Authors: Sukardi  , Sarosa Aji Hendra , Nirwana Wa Ode Cakra , Nurhadianty Vivi , Murlistyarini Sinta , Dewi Luthfi Kurnia
Published: June 2024

Pondok Pesantren Darul Muttaqin yang terletak di Kecamatan Junrejo, Kota Batu merupakan pesantren dengan misi memberikan layanan pendidikan non-profit. Sampai saat ini biaya operasional pesantren masih sangat bergantung pada donatur. Satu-satunya bidang usaha yang dimiliki oleh Pesantren Darul Muttaqin adalah usaha bengkel Abdurrahman Bin Auf (ABA) untuk mendukung operasional pesantren tetapi belum dapat menjadikan pesantren dapat mandiri secara ekonomi. Oleh karena itu, pengelola pondok pesantren Darul Muttaqin sangat ingin mengembangkan usahanya di bidang lain. Metode pelaksanaan pengabdian menggabungkan aspek pelatihan dan penelitian lapangan untuk memberikan pemahaman kepada peserta tentang suatu topik tertentu. Kendala yang dihadapi adalah keterbatasan keterampilan, ilmu pengetahuan dan teknologi. Kegiatan Doktor Mengabdi bertujuan untuk memberikan pelatihan pembuatan produk personal care berbasis minyak atsiri lokal kepada mitra dalam bentuk produk sabun dan Sampo. Pelaksanaan dilakukan dalam tiga tahap, yaitu persiapan pelaksanaan, pemberian materi dan praktik pembuatan, serta monitoring dan evaluasi. Kegiatan telah terlaksana dengan baik, hal ini ditunjukkan dengan adanya respon dari peserta pelatihan sedikit menunjukkan ketidakpuasan, yaitu sebesar 4%, dan juga kepuasan sekitar 52%.  Melalui kegiatan ini, Diharapkan ada keberlanjutan mengenai mengomersialisasikan hasil produksi dari pondok pesantren, sehingga dapat memberikan nilai tambah dalam ekonomi pondok pesantren.
Pengembangan dan pengolahan kulit buah kakao menjadi produk unggulan kreatif cookies dan kerupuk
Authors: Ramanda Muhammad Rizky , Wahyuningtyas Amalia , Utari Ni Wayan Arya
Published: June 2024

Desa Pekondoh merupakan salah satu desa yang berada di Pesawaran dengan produktivitas kakao yang cukup melimpah. Hanya saja kulit buah kakao dianggap limbah karena tidak dapat diolah dan dijul. Sehingga pemanfaatan pengolahan produk dengan menggunakan bahan baku utama yaitu kulit kakao. Kulit kakao memiliki kandungan serat yang tinggi serta antioksidan yang mampu memperlancar pencernaan pada tubuh. Sehingga solusi dari pemanfaatan kulit kakao yaitu pembuatan produk kerupuk dan cookies. Metode yang digunakan yaitu pendekatan pendekatan Participatory Action Research (PAR). Metode ini berorientasi kepada pemberdayaan masyarakat dengan mengindentifikasi masalah dan potensi serta mengajak keterlibatan masyarakat dalam kegiatan penanganan masalah berbentuk pelatihan. Kegiatan pelatihan pembuatan produk dilaksanakan di Desa Pekondoh dengan peserta warga desa tersebut. Hasil dari kegiatan pengabdian menunjukkan adanya antusias dan pemahaman peserta terhadap proses pengolahan produk kulit kakao menjadi cookies dan kerupuk. Hal tersebut ditunjukkan dari hasil posttest terkait pemahaman pembuatan produk cookies kakao yaitu sebesar 86% dan pembuatan produk kerupuk yaitu sebesar 80%. Tindak lanjut yang perlu dilakukan yaitu monitoring perkembangan produksi serta pengembangan usaha seperti membentuk badan usaha dan pendampingan pembuatan sosial media dan website.
İLAÇLARDA SANAL BİYOEŞDEĞERLİK UYGULAMALARI
Authors: Gülsün Tuğba , Demir Huriye , Öner Levent
Published: June 2024

Amaç: Sanal biyoeşdeğerlik çalışmaları hem yeni ilaçların hem de jenerik ilaçların geliştirme süreçlerini kolaylaştırma ve optimize etmede kritik rol oynamaktadır. Bu yaklaşım, ilaçların insan vücudundaki davranışlarını taklit etmek ve kestirebilmek için matematiksel hesaplamalara dayanmaktadır. Sanal biyoeşdeğerlik çalışmaları ile in vitro, in siliko ve in vivo veriler kullanılarak, test ve referans formülasyonlar arasındaki farmakokinetik ve klinik performans değerlendirebilir. Bu modeller, ilaçların vücutta nasıl dağıldığını, metabolize olduğunu ve atıldığını daha duyarlı bir şekilde tahmin edebilir. Bu sayede ilaçların etkilerinin kestirilebilmesi ve dozun optimize edilmesine olanak sağlar.
Sonuç ve Tartışma: Sanal biyoeşdeğerlik çalışmalarının yasal düzenlemelerdeki yeri henüz tam olarak belirlenememiştir, bu nedenle ilaçla ilgili yasal otoriteler, ilaç endüstrisi, üniversiteler ve araştırma kuruluşlarının iş birliği yapması oldukça önemlidir. Özellikle ağız yolu ve diğer uygulama yolları ile kullanılan sistemik etki gösteren ilaçların, fizyolojik temelli farmakokinetik ve biyofarmasötik modelleme çalışmalarının çerçevesinin belirlenmesi, in vivo klinik çalışmalardan muafiyetin ve optimizasyonunun desteklenmesi için sanal biyoeşdeğerlik çalışmaları önemlidir. Sanal biyoeşdeğerlik çalışmaları, ilaç geliştirme süreçlerini iyileştirmek, süreyi kısaltmak ve maliyetleri düşürmek için önemli bir araç olabilir, ancak bu alandaki ilerlemelerin devam etmesi ve bu yöntemlerin ilaçla ilgili yasal düzenleme süreçlerine daha fazla entegre edilmesi gerekmektedir.
Analysing Unlabeled Data with Randomness and Noise: The Case of Fishery Catch Reports
Authors: Ashrafi Aida , Tessem Bjørnar , Enberg Katja
Published: June 2024

Detecting violations within fishing activity reports is crucial for ensuring the sustainable utilization of fish resources, and employing machine learning methods holds promise for uncovering hidden patterns within this complex dataset. Given that these violations are infrequent occurrences, as fishermen generally adhere to regulations, identifying them becomes akin to an anomaly outlier detection task. Since labeled data distinguishing between normal and anomalous instances is not available for catch reports from Norwegian waters, we have opted for more conventional approaches, such as clustering methods, to identify potential clusters and outliers. Moreover, the catch reports inherently exhibit randomness and noise due to environmental factors and potential errors made by fishermen during report registration which complicates the processes of scaling, clustering, and anomaly detection. Through experimentation with various scaling and clustering techniques, we have observed that many of these methods tend to group the data based on the species caught, exhibiting a high level of agreement in cluster formation, indicating the stability of the clusters. Anomaly detection methods, however, yield varying potential outliers as it is a more challenging task.
ESTRATEGIAS DE NEGOCIO E INNOVACIÓN EN LA INDUSTRIA FRIGORIFICA CÁRNICA DE ARGENTINA
Authors: Perez Santiago Agustín
Published: June 2024

El presente trabajo desarrolla un análisis de la importancia que se le brindan a diferentes estrategias de negocios en la industria frigorífica de Argentina. Para esto se utilizaron datos de la III Encuesta Nacional de Empleo y de la Innovación, con un total de 146 frigoríficos relevados. Con los datos se llevaron a cabo análisis descriptivo de las estrategias de negocio, análisis inferencial con relación a variables estructurales de las industrias y análisis de conglomerados entre los frigoríficos. Los resultados permitieron plantear que las estrategias de alta calidad y fueron las de mayor importancia. Se pudo establecer que el tamaño empresarial y el perfil de innovación presento relación significativa con varias estrategias de negocio.
Developing guidelines and a theory of change framework to inform rewilding application
Authors: Hawkins Sally , Convery Ian , Carver Steve
Published: June 2024

Introduction

There remain a number of debates and conflicts about the concept of rewilding which can be barriers to its application. Some of these conflicts stem from the variety of contextual interpretations of rewilding, leading to conflict between rewilding theories and approaches. Conclusions have also been drawn about rewilding based on limited case studies, so that emergent rewilding theories aren’t applicable to all rewilding projects, limiting their support in the field. Past theories have distinguished different types of rewilding, encouraging debate over the proposed methods, although in practice these approaches often share similar goals and use similar interventions. One barrier to achieving consensus in the practice of rewilding is that there are no clear guidelines for rewilding, and there are limited broad-scale studies focusing on how rewilding is practiced. This paper addresses this by offering the first broad study of rewilding guidelines and interventions.

Methods

A grounded theory study was undertaken, using data sourced from rewilding organisations, case studies, and research. Expressions were coded in the data relating to intentions for how rewilding should be practiced and the interventions used.

Results

Drawing from these data, the paper offers three tools to guide rewilding practitioners: (1) an overview of guidelines for rewilding practice, (2) a list of interventions used in rewilding, considering them against rewilding goals, (3) a theory of change framework to guide rewilding application.

Discussion

The tools presented here will inform work towards IUCN rewilding guidelines. Several areas that require further consideration are highlighted. We hope that this initial study of application can improve agreement and collaboration among the rewilding community.
Necroptosis and immune infiltration in hypertrophic cardiomyopathy: novel insights from bioinformatics analyses
Authors: Hou Can , Fei Sifan , Jia Fang
Published: June 2024

Background

Hypertrophic Cardiomyopathy (HCM), a widespread genetic heart disorder, is largely associated with sudden cardiac fatality. Necroptosis, an emerging type of programmed cell death, plays a fundamental role in several cardiovascular diseases.

Aim

This research utilized bioinformatics analysis to investigate necroptosis's implication in HCM.

Methods

The study retrieved RNA sequencing datasets GSE130036 and GSE141910 from the Gene Expression Omnibus (GEO) database. It detected necroptosis-linked differentially expressed genes (NRDEGs) by reviewing both the gene set for necroptosis and the differently expressed genes (DEGs). The enriched signaling pathway of HCM was assessed using GSEA, while common DEGs were studied through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Concurrently, the Protein-Protein Interaction network (PPI) proved useful for identifying central genes. CIBERSORT facilitated evaluating the correlation between distinct immune cell-type prevalence and NRDEGs by analyzing immune infiltration patterns. Lastly, GSE141910 dataset validated the expression ranks of NRDEGs and immune-cell penetration.

Results

The investigation disclosed significant enrichment and activation of the necroptosis pathway in HCM specimens. Seventeen diverse genes, including CYBB, BCL2, and JAK2 among others, were identified in the process. PPI network scrutiny classified nine of these genes as central genes. Results from GO and KEGG enrichment analyses showed substantial connections of these genes to pathways pertaining to the HIF-1 signaling track, necroptosis, and NOD-like receptor signaling process. Moreover, an imbalance in M2 macrophage cells in HCM samples was observed. Finally, CYBB, BCL2, and JAK2 emerged as vital genes and were validated using the GSE141910 dataset.

Conclusion

These results indicate necroptosis as a probable underlying factor in HCM, with immune cell infiltration playing a part. Additionally, CYBB, BCL2, JAK2 could act as potential biomarkers for recognizing HCM. This information forms crucial insights into the basic mechanisms of HCM and could enhance its diagnosis and management.