bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of fungicides in the vegetative stage of soybean [Glycine max (L.) Merrill]: Mini-review
Authors: Santos Matheus Rodrigues dos , Andrade Christiano Lima Lobo de
Published: September 2024

The significant growth of soybean cultivation [Glycine max (L.) Merrill], and the expansion of agriculture throughout Brazil, which occurred during the period of evidence of the industrial policy of import substitution, placed the product as an ideal crop to supply the global demand was growing. Several diseases have already been reported in soybeans, but the incidence and severity depend on some factors, such as climate, cultivars, pathogen inoculum potential, soil structure and fertility, and plant vigor, among others. The disease scenario in soybean crops in Brazil has been changing every year, with an increase in the severity of some diseases, both in the aerial part and those caused by soil-dwelling fungi. The use of resistant cultivars can be adopted and is the most efficient way to control diseases. However, even with adequate management, it is necessary to apply fungicides. For more efficient disease management, it is important to know the effectiveness of the main fungicides used in the crop, in terms of their ability to reduce the progress of the disease in the field; selecting the most efficient fungicides for management. The results of the study demonstrated that fungicides positioned in different application programs reduce the incidence of fungal diseases and improve productivity.
Development Pattern of IT-Based Islamic Religious Learning After Covid-19 Pandemic in Coastal Serang Regency
Authors: Kharisul Wathoni  , Irfan Anshori  , Rumbang Sirojudin  , Yuttana Kuakul  , Wasehudin  , Miftachul Huda
Published: September 2024

Purpose - This study aims to determine the learning rate of Islamic religious education in the new-normal era after the COVID-19 pandemic in the coastal areas of Serang Regency. The constantly growing use of information technology has made most students reluctant to go to school.
Design/methods/approach – This study is qualitative research. This research approach is descriptive. The data collection techniques used were observation, interview, and documentation. The number of informants in this study included students, teachers, and the community as parents of students. The respondent selection technique used purposive sampling, where the number of informants was 90% of the total sample.
Findings - The findings in this study have included the use of a home visit strategy for post-pandemic learning continuity, where most students were reluctant to go to school and many students were contaminated with online games. The home visit method is a real form of visiting students one by one to provide understanding to parents and students about online learning, as well as a form of direct monitoring of the student learning process.
Research implications/limitations – This research highlights how the educational process of the new normal era after the COVID-19 pandemic was in the coastal area of Serang Regency. Supposedly, the coastal area is a geographical location far from urban conditions, making the infrastructure aspect still very limited.
Originality/value - This study presents the serious impact that occurred in the coastal area of Serang Regency when the learning process took place after the COVID-19 pandemic. Ranging from the personal pick-up strategy to numerous students who were reluctant to go to school to many students who were contaminated by online games.
Effective Management to Support Tahfidz Al-Qur’ān Course in Indonesian Islamic Higher Education
Authors: Nasrulloh  , Rijal Hamim Syaiful , Mahendra Wirayudha , Muhammad
Published: September 2024

The purpose of this study is (was) to determine the management of the tahfidz al-Qur’ān course at UIN Sunan Kalijaga Yogyakarta and UIN Malang and to find out the factors that influence the differences between the two and their relevance in the development of tahfidz al-Qur’ān courses in the two universities. This type of research was included into the empirical-qualitative category using Miles and Huberman-style analysis. The data collection was taken from interviews, observations and documentation. The standards of the management theory as the reference were the five principles set by Fayol. The results of this study present that the management of the tahfidz al-Qur’an course at UIN Sunan Kalijaga Yogyakarta and UIN Malang had several similarities and differences in terms of planning. Each lecturer provided the explanations related to targets and memorization and memorization deposit mechanisms. The differences from the two were only the methods and targets set. As for the Organizing, Commanding, Coordinating and Controlling sides, it was broadly the same. What distinguished was only the technical implementation. The factors that influenced the existence of differences in the management of the the tahfidz al-Qur’an course were the absence of standard provisions and rules on the methods in teaching tahfidz al-Qur’an courses between the two universities. Tahfidz course management has relevance to the development into the Department of Qur’anic Studies matters in terms of graduate achievement and competence. This research gives a message that the lecturers of tahfidz courses have to make special strategies that can be applied uniformly by every tahfidz course supervisor in higher education.
Manhaj Ibn ‘Aṭiyyah fī al-Taʻāmul ma’a al-Isrā’īliyyāt fī al-Muḥarrar al-Wajīz
Authors: Isnaini Subi Nur
Published: September 2024

This article aims to explain Ibn Atiyya’s method to revealing Israiliyyat stories in his interpretation of al-Muharrar al-Wajiz. This research is an attempt to see how far Ibn Atiyya’s consistency is in applying the general method he has described in the preliminary of his tafsir when interacting with Israiliyyat stories. Apart from that, this research also seeks to explore Ibn Atiyya’s detailed method when presenting the Israiliyyat narrations in its interpretation and expose the practical examples as the application of the method. Using the analytical descriptive method, this study finds that Ibn Atiyya is quite consistent in applying the general method he has described in the preliminary of his tafsir by mentioning important Israiliyyat stories that can’t be separated from the explanation of the meaning of the verse. In contrast to the previous commentators who mentioned the Israiliyyat narrations in length and width, Ibn Atiyya described Israiliyyat reports briefly and criticized the narrations that had no basis or arguments sahih that could be justified. In addition, this study also found that Ibn Atiyya was careful in taking Israiliyyat stories and trying to free the tafsir from the Israiliyyat stories which was not based on the explanation of the Prophet Muhammad. Ibn Atiyyah also calls for reducing the stories of Israiliyyat in the tafsir literature and sometimes also adding comments and criticisms to the narrations of Israiliyyat that he mentions.
Modern Arts of the Qur’an and its Aesthetic Reception of the Qur’anic Marble Inscription in Indonesia
Authors: Nurani Shinta , Maulana Luthfi
Published: September 2024

This article explores the aesthetic reception of the modern marble inscription of the Qur'an and its underlying meaning. The study uses field research and locates its research locus at Masjid Al-Muhtaram, Kajen, Pekalongan Regency where the marble stone is kept. The research adopts Wolfgang Iser's reception theory to analyse the meaning of the marble stone Al-Qur'an from an aesthetic standpoint. The results show that the marble stone inscription of the Qur'an was made by Nur Hidayat Siba, starting in 2011 until 2021, and has reached 13 juz of the Qur'an. The marble measures 60 x 90 cm with a thickness of 2 cm, and is written with beautiful khat and gold colour wrapping on every khat. The inscription provides three meanings of aesthetic reception. Firstly, the objective meaning of the Qur'an as a holy book must be preserved through beautiful media as a form of appreciation for the greatness of the Qur'an. Secondly, the expressive meaning is used as a medium of Islamic da'wa, and spirituality increases faith and religious aspects for those who see and read it. Finally, the meaning of documentary serves as a form of habitus to always interact with the Qur'an in everyday life. These three meanings illustrate the diversity of meanings in the aesthetic reception of the marble Al-Qur'an. The study contributes to the body of knowledge by shedding light on the significance of aesthetic reception of the Qur'an and highlights the importance of preserving the holy book through beautiful media.
The Origin of Esotericism: An Analysis of the Ismaili Esoteric Approach to Qur’anic Interpretation
Authors: Mahmoud Ramy
Published: September 2024

This study examines the Ismaili method of interpreting Qur’anic verses, focusing on their esoteric hermeneutics. The Quran serves as a fundamental legislative source for various theological factions, each seeking to substantiate their claims by referencing its verses. It also stands as a principal source for muhaddithin, fuqahā (jurisprudents), and others, contributing to the emergence of tafsir, a discipline aimed at elucidating the Quran's meanings and intentions. Consequently, different schools of interpretation, or tafsir, have developed over time. One strand of interpretation adheres to the literal meaning of the text, known as Zāhir, while another explores mystical or esoteric meanings, termed Bātin, occasionally without strong support from Arabic language or Qur’anic and Hadith evidence. Among Shiite sects, the Ismailis distinguish themselves as one of the most enduring, recognizing Ismail bin Ja'far al-Sādiq as their Imam and establishing influential states in Islamic history, such as the Qarmatian state in Bahrain (899–1077) and the Fatimid Caliphate in North Africa (909/1171). To thoroughly investigate this subject, a qualitative research approach is proposed. Given the historical and theological nature of the topic, qualitative methods, such as textual analysis and historical research, facilitate a comprehensive exploration and interpretation of complex phenomena. The findings of this research indicate that Ismailism has heavily relied on the esoteric interpretation of Qur’anic verses since its inception, aligning with Ismaili belief systems, with Qur’anic verses assuming a more significant role than Hadith in their doctrinal framework. The essence of this article lies in delving into the Ismaili approach to esoteric hermeneutics, predominantly drawing from the sect's primary sources.
The Rejection of Prophetic Traditions: Analyzing the Inkar Sunnah Movement in West Sumatra, Indonesia
Authors: Hakim Luqmanul , Yasti Suci Amalia , Ananda Yassinta
Published: September 2024

This article explores the ideological stance of the Inkar Sunnah movement, which rejects the prophetic traditions (Sunnah) as a source of Islamic law, focusing on its development in West Sumatra, Indonesia. Historically, this movement can be traced back to political and sectarian conflicts in early Islamic history, such as those involving the Khawarij, Shia, and Mu'tazilah sects. Over time, skepticism towards hadith, fueled by fabricated traditions and modern Orientalist critiques, gained traction. Prominent figures like Dalimi Lubis and Nazwar Syamsu have continued to propagate Inkar Sunnah beliefs in modern Indonesia, advocating that the Qur’an alone suffices for Islamic jurisprudence. This research adopts a qualitative library approach, analyzing primary texts by these figures and secondary sources on hadith scholarship. The study critically examines their arguments and the socio-political context that allowed their ideas to proliferate, as well as strategies to counter this ideological challenge within Indonesian Islamic discourse. The findings reveal a persistent tension between traditional Sunni orthodoxy and reformist interpretations that seek to minimize or outright reject the role of the Sunnah, posing significant implications for Islamic legal and theological frameworks.
Peluang dan Tantangan Indonesia-Australia Comprehensive Strategic Partnership Pasca Terbentuknya Kerja Sama Pertahanan Trilateral AUKUS
Authors: Saputro Pradono Budi , Ulung A. Kurniawan , Abdurrohim Muhammad , Hafizh Al
Published: September 2024

Indonesia and Australia are neighboring countries with fluctuate bilateral relations. In 2018, they formed Indonesia-Australia Comprehensive Strategic Partnership (IA-CSP) to enhance their partnerships in strategic sectors for the stability of regional security in the Indo-Pacific. However, the problem came up in 2021 when Australia established trilateral defense cooperation AUKUS with the United Kingdom and the United States. This cooperation facilitates Australia to have nuclear-powered submarines to strengthen its military power. This cooperation has raised the eyebrows of Indonesia as it is against IA-CSP’s pillars, particularly pillar on securing the two countries and the region’s shared interest, and pillar on contributing to Indo-Pacific stability and prosperity. Therefore, Indonesia regretted Australia’s participation in AUKUS because the former deemed the latter to have violated its commitment on IA-CSP. This research aims to analyze IA-CSP’s opportunities and challenges post-establishment of AUKUS. It used a qualitative method, with interviews and literature review in place to collect data. The authors used regional security complex theory and strategic partnership concept for analysis. This research found that AUKUS does not disrupt the implementation of IA-CSP because the cooperation instead provides opportunities that Indonesia can utilize for its national interest. However, AUKUS poses challenges that Indonesia needs to tackle.
External Perceptions and Indonesia's Leadership Role in Indo-Pacific Maritime Affairs
Authors: Samy Muhammad
Published: September 2024

Bahasa Indonesia:Visi Indonesia untuk menjadi pemimpin kawasan dalam hal kemaritiman telah menjadi isu yang diperdebatkan oleh akademisi maupun politis. Beberapa akademisi berargumen bahwa Indonesia tidak dapat menjalankan peran sebagai pemimpin kawasan dalam hal kemaritiman karena lemahnya kehendak politik, kurangnya sumber daya, serta lemahnya persepsi diri sebagai pemimpin. Dengan menggunakan kerangka analisis teori peran, tulisan ini menghadirkan jawaban alternatif terhadap isu kepimpinan regional Indonesia dalam hal kemaritiman. Tulisan ini berargumen bahwa Indonesia memang memandang diri sebagai pemimpin kawasan dalam hal kemaritiman, namun masalah dalam menjalankan kepemimpinan tersebut terletak pada lemahnya persepsi eksternal atas kepemimpinan Indonesia.English:Indonesia’s aspirations of becoming a leader in regional maritime affair has become a point of contention among scholars and politicians alike. Many scholars argue that Indonesia is unable to effectively take on the role of a regional leader in maritime affairs due to weak political will, lack of resource, or lack of self-perception as both a maritime state and regional leader. Building upon the analytical framework of role theory, this paper brings forth a different answer to the question of Indonesia’s leadership in regional maritime affairs. This paper argues that Indonesia does view itself as a maritime state and regional leader, and that the issue of Indonesia’s leadership is rooted in the lack of external perception towards Indonesia’s leadership in regional maritime affairs.
The communication language and the fair trial in Cameroon
Authors: Cyrille Monkam
Published: September 2024

This paper deals with the incidence of communication channels treatment during court proceedings in a multilingual context like Cameroon. On the one hand, I will defend on the one hand the idea according to which the unbalanced treatment enshrined in the constitution, which confers preferential treatment to the so-called official, but imported languages and a marginal role to other local languages termed as national as well as other means of expression, affects the communication before courtrooms. The use of the former is reserved for an elitist minority group while that of the latter for a majority illiterate group. On the other hand, there has been an effort on the part of the state to curb this discrimination through the linguistic assistance. But still, there are challenges that confirm the legitimate fears of litigants, better lay-litigants of violation of their rights of access to justice and fair trial at large. The paper then suggests to the State to enhance the promotion of national languages, to emphasize on the training of judicial personnel and public awareness.
Association between cerebrospinal fluid chitotriosidase level and amyotrophic lateral sclerosis: a systematic review
Authors: Khorshidi Zeinab , Adibi Iman , Ghasemi Majid
Published: September 2024

Introduction

One of the fatal and debilitating neurodegenerative diseases is amyotrophic lateral sclerosis (ALS). Increasing age is one of the risk factors of ALS. Considering that the elderly population in the world is increasing, it is very important to identify useful and effective diagnostic and treatment methods. The purpose of this systematic review is to determine the relationship between chitotriosidase (CHIT1) level and ALS disorder.

Content

Keywords “Amyotrophic Lateral Sclerosis”, “Gehrig* Disease”, “Charcot Disease”, “Guam Disease”, ALS, CHIT1 and chitotriosidase were searched in PubMed, Scopus, Web of Science and Science Direct databases without time limit on September 2023. Hundred twenty studies were obtained by searching, and finally, 14 studies were included in this study using the inclusion and exclusion criteria. In all 14 selected studies, the level of biomarker CHIT1 in the CSF of ALS patients was significantly higher than that of healthy control and disease control groups. But, in 8 studies that included 3 groups, no significant difference was observed between the CHIT1 levels in the two control groups. Six studies have reported the amount of CHIT1 level quantitatively. Among these 6 studies, in 5 studies CHIT1 level in disease control was higher than healthy control (not significant) and in only one study CHIT1 level was higher in healthy control compared to disease control (not significant).

Summary and outlook

In all 14 studies, a multifold increase in CHIT1 levels has been observed in patients compared to healthy and disease control groups. Therefore, based on the findings of the studies, this study confirms the relationship between CHIT1 increase and ALS disorder.
Main heat transport system configuration influence on steam drum level control and safety for a pressure tube type boiling water reactor with multiple interconnected loops
Authors: Gaikwad Avinash J. , Maheshwari Naresh K. , Kumar Naveen
Published: September 2024

NCABWR (Natural-Circulation-Advanced-Boiling-Water-Reactor) is a pressure-tube-type BWR with multiple inter-connected Main-Heat-Transport (MHT) system loops and steam drums (SDs). SD-Level-Control is related to, the MHT coolant inventory and sustained heat removal, hence the overall safety of the Nuclear-Power-Plant (NPP). SD-Level is vital for ensuring presence of adequate coolant-inventory with sufficient and prolonged cooling of fuel, for normal-operation and accidents. In the initial-MHT-configuration of NCABWR the four MHT-loops are, inter-connected at the Common-Reactor-Inlet-Header (CRIH), which influences the SDLC adversely; such occurrences are, not reported in the open literature. Open loop (without SD-level-controllers) step-change response showed that initial MHT-configuration response is stable, non-oscillatory and non-diverging even for a high-magnitude step-change in the feed-flows. Closed-loop (with SD-level-controllers) response, even to minor disturbances leads to diverging SD-Levels due to CRIH-MHT-configuration (Gaikwad, A.J., Vijayan, P., Iyer, K., Bhartiya, S., Kumar, R., Lele, H.G., Ghosh, A.K., Kushwaha, H.S., and Sinha, R.K. (2009). Effect of loop configuration on steam drum level control for a multiple drum interconnected loops pressure tube type boiling water reactor. IEEE Trans. Nucl. Sci. 56: 3712–3725). CRIH is required to overcome Postulated-Initiating-Event (PIE) for single-accumulator-failure-LOCA. A hypothetical MHT-configuration with partitioning of CRIH will isolate each loop from one another and lead to a stable SDLC, but then for the above-mentioned PIE safety is not met. LOCA in one of the four ECCS header-compartments require a mandatory interconnection among, the four MHT-Loops at CRIH. Solution to SDLC issue were explored with changes in MHT-configuration and with innovative solution-schemes for feed-water-system and SDLCs. In the present study the pioneering solution-schemes with individual SD pressure control for SD level control and the Split/Double baffle are proposed, implemented and the performance was tested with simulation are discussed in details with other solution schemes.
Role of FOXM1 and AURKB in regulating keratinocyte function in psoriasis
Authors: Zhao Zhaofeng , Cheng Jie , Hou Qiang , Zhu Jian , Chen Tu , Lu Sheng , Wu Guiju , Lv Hongli , Wu Xiujuan
Published: September 2024

Objective

This study investigated the effect of forkhead box M1 (FOXM1) and Aurora kinase B (AURKB) on the epidermal function of keratinocytes.

Methods

Bioinformatics analysis was used to analyze the co-expression network of FOXM1 and its correlation with AURKB. The expression of FOXM1 and AURKB in tissues and cells was detected by immunofluorescence and real-time quantitative polymerase chain reaction, respectively. HaCaT cells were transfected with si-FOXM1 to knock down FOXM1. Cell proliferation was detected by cell counting kit-8 assay. Cell migration was detected by scratch assay. Cell invasion was detected by the Transwell invasion assay. Cell apoptosis and cell cycle were detected by flow cytometry.

Results

FOXM1 and AURKB were positively correlated and highly expressed in psoriatic lesions. After transfection of si-FOXM1, the expression levels of FOXM1 and AURKB genes significantly decreased. The proliferation of HaCaT cells decreased, the apoptosis rate increased significantly, and the proportion of cells in the G1 phase increased significantly, while the proportion of cells in the S phase decreased significantly. The scratch closure of HaCaT cells was reduced, and the number of cell invasions decreased significantly.

Conclusion

FOXM1 and AURKB may affect the progression of psoriasis by regulating the proliferation, cell cycle, migration, and invasion of keratinocytes.
The crystal structure of 1,2-bis(4-(dimethylamino)phenyl)ethane-1,2-dione. C18H20N2O2
Authors: Yuchang Du , Jiarui He , Yan Li , Guimei Zeng , Wenhua Liu
Published: September 2024

C18H20N2O2, triclinic, P1̄ (no. 2), a = 9.9301(5) Å, b = 10.6446(5) Å, c = 15.2690(8) Å, α = 77.743(2)°, β = 87.460(2)°, γ = 89.139(2)°, V = 1575.60(14) Å3, Z = 4, R

gt
(F) = 0.0465, wR

ref
(F
2) = 0.1188, T = 150 K.
Investigation of varying tip clearance gap and operating conditions on the fulfilment of low-speed axial flow fan
Authors: Vala Jignesh R. , Patel Dinesh K. , Darji Anand P. , Natrayan L.
Published: September 2024

The present study aims to identify the suitable tip clearance and volumetric flow rates for low-speed axial flow fans. The performance of an axial fan depends on various parameters like fan speed, available tip clearance gap, volumetric flow rate, power consumption, and working fluid. Leakage flow occurring at a rotating component such as a blade and solid casing of a ducted axial fan is typically linked to losses and the potential emergence of a rotating stall. The numerical analysis for this study uses the Reynolds Averaged Navier–Stokes equations with the k-omega SST turbulence model to perform the steady-state simulations by varying tip gap and volumetric flow rate. The results proved that the optimum performance was obtained with a tip clearance gap of 1 mm, and maximum fan efficiency was achieved at a volumetric flow rate of 3.9–4.5 m3/s. The novelty of this proposed work is to enhance the efficiency of axial flow fans with circular arc-cambered aerofoils using optimum tip clearance and volumetric flow rate through steady-state simulations. This method can be used in turbomachinery to improve fan performance.
Exploring Intention & Reactance in Social Norm Interventions for Rail Business Travel
Authors: Müller Adrian , Stauch Alexander
Published: September 2024

Shifting continental business travel from carbon-intensive modes to rail is crucial for emissions reduction. Behavioral interventions are a way to achieve this, but a gap exists in understanding their efficacy for sustainable business travel behavior. Based on online experiments with frequent business travelers, we scrutinize the impact of descriptive social norm interventions on mode choice intention, considering potentially negative employee reactions. While revealing factors influencing reactance and intention, contrary to expectations derived from the theory of planned behavior, behavioral interventions literature, and psychological reactance theory, our social norm treatments did not significantly impact mode choice intention and resulted in low reactance levels. Despite these unexpected results indicating that our interventions did not yield the desired changes, our study underscores the challenges of influencing sustainable business travel behavior and emphasizes the need for tailored interventions and incentives in practice, suggesting avenues for further research.
Tourists’ Experiences During the Covid-19 Pandemic in Plateau State, Nigeria: An Empirical Evaluation Using Chaos Theory
Authors:   Stellenbosch University, Department of Geography and Environmental Studies, Tina Odinakachi Iirmdu , Donaldson Ronnie ,   Stellenbosch University, Faculty of Arts and Social Sciences, Department of Geography and Environmental Studies
Published: September 2024

The safety of tourists’ health when visiting any tourism business is critical in tourism management and development. By using chaos theory, this study aimed to understand how 408 tourists in Plateau State, Nigeria, behaved toward tourism-related businesses during the COVID-19 pandemic. Completed and retrieved responses were analyzed descriptively using an inductive method, following a pragmatic approach. The findings of this investigation are consistent with chaos theory. Results from our survey indicate that 93% of tourists took precautions. This suggests that in an otherwise random and chaotic period of the tourism crisis, self-organization brought order and new stability. With a mean score of 40%, safety and hygiene were ranked as the two main influencing factors that changed tourists’ actual behaviour during the pandemic. The alteration in behaviour might be attributed to tourists’ awareness of their risk of catching the COVID-19 virus when visiting tourist attractions. Empirical evidence shows that non-interactive restriction techniques had a significant impact on tourist behaviour. Thus, the impact of the pandemic on tourists’ protective behaviour continues to play a part in tourists’ behaviour during and after the pandemic, implying that the chaos theory approach might be used as a crisis management tool in the tourism industry.
Adjacent Neuronal Fascicle Guides Motoneuron 24 Dendritic Branching and Axonal Routing Decisions through Dscam1 Signaling
Authors: Bui Kathy Clara , Kamiyama Daichi
Published: September 2024

The formation and precise positioning of axons and dendrites are crucial for the development of neural circuits. Although juxtacrine signaling via cell–cell contact is known to influence these processes, the specific structures and mechanisms regulating neuronal process positioning within the central nervous system (CNS) remain to be fully identified. Our study investigates motoneuron 24 (MN24) in theDrosophilaembryonic CNS, which is characterized by a complex yet stereotyped axon projection pattern, known as “axonal routing.” In this motoneuron, the primary dendritic branches project laterally toward the midline, specifically emerging at the sites where axons turn. We observed that Scp2-positive neurons contribute to the lateral fascicle structure in the ventral nerve cord (VNC) near MN24 dendrites. Notably, the knockout of the Down syndrome cell adhesion molecule (Dscam1) results in the loss of dendrites and disruption of proper axonal routing in MN24, while not affecting the formation of the fascicle structure. Through cell-type specific knockdown and rescue experiments of Dscam1, we have determined that the interaction between MN24 and Scp2-positive fascicle, mediated by Dscam1, promotes the development of both dendrites and axonal routing. Our findings demonstrate that the holistic configuration of neuronal structures, such as axons and dendrites, within single motoneurons can be governed by local contact with the adjacent neuron fascicle, a novel reference structure for neural circuitry wiring.
BMP Antagonist Gremlin 2 Regulates Hippocampal Neurogenesis and Is Associated with Seizure Susceptibility and Anxiety
Authors: Frazer Nicolette B. , Kaas Garrett A. , Firmin Caroline G. , Gamazon Eric R. , Hatzopoulos Antonis K.
Published: September 2024

The Bone Morphogenetic Protein (BMP) signaling pathway is vital in neural progenitor cell proliferation, specification, and differentiation. The BMP signaling antagonist Gremlin 2 (Grem2) is the most potent natural inhibitor of BMP expressed in the adult brain; however its function remains unknown. To address this knowledge gap, we have analyzed mice lacking Grem2 via homologous recombination (Grem2−/−). Histological analysis of brain sections revealed significant scattering of CA3 pyramidal cells within the dentate hilus in the hippocampus ofGrem2−/−mice. Furthermore, the number of proliferating neural stem cells and neuroblasts was significantly decreased in the subgranular zone ofGrem2−/−mice compared with that of wild-type (WT) controls. Due to the role of hippocampal neurogenesis in neurological disorders, we tested mice on a battery of neurobehavioral tests.Grem2−/−mice exhibited increased anxiety on the elevated zero maze in response to acute and chronic stress. Specifically, maleGrem2−/−mice showed increased anxiogenesis following chronic stress, and this was correlated with higher levels of BMP signaling and decreased proliferation in the dentate gyrus. Additionally, when chemically challenged with kainic acid,Grem2−/−mice displayed a higher susceptibility to and increased severity of seizures compared with WTs. Together, our data indicate that Grem2 regulates BMP signaling and is vital in maintaining homeostasis in adult hippocampal neurogenesis and structure. Furthermore, the lack of Grem2 contributes to the development and progression of neurogenesis-related disorders such as anxiety and epilepsy.
THE USE OF ICT TO PROVIDE THE COMPONENTS OF THE METHODICAL SYSTEM OF TEACHING UKRAINIAN LANGUAGE FOR PROFESSIONAL PURPOSES
Authors: Humeniuk Iryna
Published: September 2024

The article studies the potential of information and communications technology in teaching Ukrainian Language for Professional Purposes to future experts in pedagogy. The matter of applying information and communications technology in the process of distance education became relevant in 2020 due to the COVID-19 pandemic and is gaining more and more importance during the martial law in Ukraine. In the research process, a set of theoretical, empirical, and graphical methods has been used: studying the scientific sources in order to establish the degree of resolution of the problem; abstraction, comparison, and generalization to substantiate the conceptual apparatus of the research; observation, self-observation, and experimental teaching to implement and verify the distance learning system of Ukrainian Language for Professional Purposes; the methods of structuring and modeling objects for visualization and generalization of the research results. Within the article, the ability of information and communications technology to provide every component of the methodical system of teaching Ukrainian Language for Professional Purposes is examined: methodological and target-oriented, content-based, procedural, and evaluative. For this purpose, the didactic and technical potential of the D-Learn distance education platform of Vasyl Stefanyk Precarpathian National University has been analyzed, the structuring and step-by-step description of the experimental distance course have been conducted, and the services of information and communications technology have been organized according to the components of the methodical system of teaching Ukrainian Language for Professional Purposes and visualized. The increasing importance of students’ independent work during informational and research projects is emphasized, and sample tasks for their research work on the Internet are provided. The potential of online programs for monitoring, evaluating and recording learning results has been revealed, due to which the possibility of subjective inaccuracies is eliminated.
PECULIARITIES OF THE DEVELOPMENT OF MEDIA EDUCATION IN UKRAINE AND POLAND IN THE CONTEXT OF EUROPEAN INTEGRATION OF EDUCATIONAL PROCESS
Authors: Prokopiv Liubov , Dereniuk Mariana
Published: September 2024

Peculiarities of the formation of media education in Ukraine and Poland in the context of European integration have been clarified in the article. The meaning of the concept of "media education" and the necessity of its introduction have been reflected. The comparative aspect is used to analye the main characteristics of formation of media education in Ukraine and Poland and the current state of media education of the studied countries. The development of media education in Ukraine is mainly characterized by three groups of socio-political and socio-economic changes: firstly, increasing changes in the global and national economy; secondly, international compulsory standards for formation of Ukrainian educational system; thirdly, an urgent prevention of information violence. In Poland we have divided the development of media education in Poland into several stages: the first stage - 90s of the XX century – 1995; the third stage – 2008 - 2019; the fourth stage - 2019 – until now. The conducted content analysis has shown the main aspects of the development of media education in Poland in percentages selection and analysis of a large number of information sources; the right choice of information source;analysing the alternative source of information; awareness that information can be true and false; questioning the truth of received information; review the truth of certain information, that is, an attempt to be critical to information. The education system should have the main place in the development of young generation of Ukrainian identity, patriotism preventing the external disinformation The modern achievements of Polish educational institutions such as basic training courses, forms and methods of teaching are revealed. The achievements of Ukrainian pedagogical science in the field of media education are highlighted. It is proved the importance of providing the system of media education with educational resources and institutional support. A comparative analysis has been used to compare the state of media education development in Ukraine and Poland.
THE ROLE OF WRITERS IN THE FORMATION AND DEVELOPMENT OF UKRAINIAN CHILDREN'S PERIODICALS IN TRANSCARPATIA IN THE 1920s-1930s XX CENTURY
Authors: Lemak Oksana
Published: September 2024

The raised problem is actualized by the scientific interest and practical significance of the study of the historical experience of the development of children's periodicals in Ukraine. Its interesting original page is the process of creation and development of children's magazines in Transcarpathia in the 20s and 30s. ХХ th century The purpose and task of the research is to find out the role and contribution of Ukrainian literati (poets, writers, editors) in the formation and development of children's periodicals of Transcarpathia in the 20s and 30s of the ХХth century. The following methods were used in the preparation of the study: heuristic-search; analysis and synthesis; content analysis and discourse analysis; biographical. The results of the research consist in clarifying the role and contribution of Ukrainian writers and teachers (Agustyn Voloshyn, Oleksandr Markush, Ivan Pankevich, Pavlo Kukuruza, etc.) in the founding and development of the children's magazines "Wreath for Podkarpatskyi Children" and "Pchilka". Their role in publishing the youth magazine "Nash nadny kray" is shown. Emphasis is placed on highlighting the organizational and methodological experience of the Pchilka magazine editorial office in organizing school holidays in honor of Ukrainian writers, school libraries and reading rooms, exhibitions, reading circles (clubs). The forms and methods of establishing feedback from the "Bee" editorial office with readers are shown, which is manifested in the introduction of special sections, the publication of their poems and stories on the magazine's page, etc. The conclusions state that famous Ukrainian writers and poets of Transcarpathia and emigrants from Galicia and Trans- Dnipro Ukraine were prominent initiators and organizers of the process of founding and developing children's periodicals in Transcarpathia in the 20s and 30s of the XX century. As professional writers and editors and, in the vast majority, professional teachers, they ensured that children's magazines not only presented the best achievements of children's poetry and prose to the reader, but also became important effective organizational and methodical centers for the formation and development of interest in the artistic word, aesthetic tastes, reading culture. The experience of the editors of children's magazines in stimulating the creative activity of schoolchildren, establishing feedback with the reader, developing methods for arranging school libraries, exhibitions, organizing group work, etc., has not lost its relevance.
INCLUSIVE PHYSICAL EDUCATION AS A TOOL FOR FORMING THE EDUCATIONAL ENVIRONMENT FOR STUDENTS WITH DISABILITIES
Authors: Blavt Oksana
Published: September 2024

The article examines the role of physical education in the prevention of unsatisfactory adaptation to the learning process in a university. The purpose of the study is to identify the possibility of the discipline "Physical education" in the formation of adaptation to the educational environment of a university in students with disabilities through inclusive physical education. The research is based on the use of a complex of general scientific theoretical methods: analysis, synthesis, systematization, and generalization. It was established that inclusive physical education provides a special organization of the educational environment in a university, aimed at preventing existing negative trends in the health of students with disabilities, due to the process of adaptation, which involves technology and the organization of diagnostic and health facilities for students with disabilities. The main functions of inclusive physical education have been systematized, the implementation of which will ensure the prevention of unsatisfactory adaptation to the learning process in a university for students with disabilities: organizational and methodical, educational, correctional, educational and advisory, developmental. Among the main forms of physical improvement, it is necessary to use along with the main classes in physical education, integrated a small forms. In general, the success of the adaptation process to the educational environment for students with disabilities in the process of physical education is determined by the rational organization of methodical support aimed at strengthening the individual health of the participants in the pedagogical process, taking into account the individual characteristics of adaptation to physical loads, the step-by-step application of complex assessment methods and control. As a result, the idea of using the means of inclusive physical education as a tool for shaping the adaptation of students with disabilities to the educational environment of a university has been expanded. The latter involves the effective organization of physical education of students with disabilities for educating them in a responsible attitude to their health, and a healthy lifestyle; formation of knowledge and skills of physical culture; ensuring full-fledged physical development; physical, spiritual, and mental hardening; formation of the need for safe behavior, counteraction and prevention of negative habits, prevention of diseases; creation of conditions for active recreation in the conditions of study at a university.
Unidade temática de lutas e esportes de combate na educação física escolar do ensino fundamental no Norte do Brasil
Authors: Sousa de Aragão Ademar , De Oliveira Adrieny Bernardo , Ribeiro de Miranda Milton Rafael , Janotta Drigo Alexandre , Borba-Pinheiro Claudio Joaquim
Published: September 2024

The objective of this study was to analyze the understanding of school physical education (SPE) students and teachers about the causes and restrictions that imply the content of fights in 6th and 7th-year elementary school classes in public schools in Tucuruí-PA-Brazil. 40 6th and 7th-grade students from two public schools and two teachers participated in the research. A descriptive-cross-sectional study was carried out on the content of fights at school. The results showed that teachers teach fight content and preferably use playful activities; they believe that it should be included in early childhood education and that it does not generate violence. As for the students, although they participate in the classes, they do not seem to be attractive; many consider that the way the content is taught can generate violence. In conclusion, fighting content can positively influence student performance and learning when taught at EFE. However, the teacher must understand and face this content's difficulties and controversies to teach classes theoretically and practically with creativity because there are still gaps between what teachers do and what students expect from the content.
Vitalidad en movimiento: la experiencia de la actividad física musicalizada en la calidad de vida del adulto mayor
Authors: García García José Alexander , Solano García Hernán Felipe , Benavides Rodríguez Cindy Lorena
Published: September 2024

To establish the impact of musicalized physical activity on the quality of life of older adults. The present research adopts a qualitative approach through a narrative design, using semi-structured interviews as a method of data collection. Content analysis was used to address dimensions such as self-concept, socioemotional skills, health, and physical well-being. A positive impact on self-esteem and interpersonal relationships, improvements in conflict resolution and communication skills, as well as gains in vitality, physical and mental well-being are highlighted. In addition, the constant motivation to remain active in the area of physical wellbeing is highlighted. The findings provide contextualized evidence of the positive impacts that community-based physical activity programs have on the overall quality of life of older adults. The experiences and testimonies of the participants highlight concrete impacts on fundamental biopsychosocial dimensions to promote active and healthy aging.
Análise da produção do conhecimento em periódicos brasileiros sobre o treinamento esportivo de corredores de rua
Authors: Marques Vieira-Souza Lucio , Da Silva Reis Natanael Vitor , Da Silva Reis Natan Vinicius , Aidar Felipe J. , Rosa Jean Lucas , Barbosa Luís Fabiano , Brito Ciro José , Lopes dos Santos Jymmys , Prado Nunes Paulo Ricardo , Xavier de Oliveira Donizete Cícero , Souza Gislaine Cristina-
Published: September 2024

This research aimed to analyze the types and methods of training that street runners in Brazil use in their periodization. It is a study based on secondary data from publications in Brazilian academic journals in the area of ​​physical education that analyzed and recorded, after the first filter, 72 articles published in Brazilian journals. The first article was published in 2009 and the years with the highest number of articles published were 2018 and 2019. The Brazilian Journal of Exercise Prescription and Physiology presented the highest number of publications. This study investigated whether street runners follow any training model (periodized, interval, intermittent, among others) and, thus, brought a way to assist sports professionals with the methods and development of training for professional and beginner street runners and thus improve the performance of runners and contribute to the prevention of injuries.
Neurological Mechanisms of Long COVID
Authors: Hsia Tzu-Jiuan
Published: September 2024

Long COVID, also known as post-acute sequelae of SARS-CoV-2 infection, refers to a condition where individuals continue to experience a range of symptoms weeks to months after the acute phase of COVID-19 has resolved. While respiratory symptoms are commonly associated with COVID-19, emerging evidence suggests that neurological manifestations play a significant role in the long-term effects of the disease. This article explores the neurological basis of long COVID, delving into the various symptoms, pathophysiological mechanisms, impact on cognitive function, neuroimaging findings, current treatment approaches, long-term prognosis, and future research directions in understanding and managing the neurological sequelae of long COVID.
TAIGA HEADING NORTH
Authors: Воронов Ю.П.
Published: September 2024

В статье рассмотрена проблема продвижения тайги на север как части последствий изменения климата в мире. Цель публикации состоит в том, чтобы исследовать новые возможности для развития экономики Сибири, а также систематизировать основные направления адаптации экономики к изменяющимся условиям хозяйствования. Расширение пло­щади тайги увеличивает лесные ресурсы России. Изменяется состав тайги: сокращается доля лиственницы и сосны, на их место приходят кедр и ель, а также смешанные леса. Происходят изменения и в составе диких животных, и в структуре рыб, обитающих в морях, реках и прес­ных водоемах. Автором проанализированы результаты ранее проведен­ных исследований по данной теме, систематизированы и интегрированы их результаты. В настоящее время наблюдается отставание российской (в част­ности, сибирской) науки от мировой в прогнозировании изменений кли­мата и их последствий, а также в разработке и применении матема­тических моделей, на которых базируются прогнозы. Второй недоста­ток, от которого нужно избавиться, состоит в подходе к затронутой проблеме, который выявился в системе государственного управления, а именно в ожидании от изменений климата исключительно потенци­ального ущерба. По мнению автора, продвижение тайги на российский север расширяет возможности развития экономики страны.

This article examines the northward advancement of the taiga as one of the consequences of global climate change. The objective of the publication is to explore new opportunities for the development of Siberia’s economy, as well as to systematize the key strategies for the economy’s adaptation to evolving conditions. The expansion of the taiga is increasing Russia’s forest resources. Its composition is altering: the proportion of larch and pine is decreasing, replaced by cedar, spruce, and mixed forests. These changes are also affecting the composition of wild animal populations and the structure of fish species in seas, rivers, and freshwater bodies. The author reviews previous research on this topic, systematizes, and integrates the results. We note a current lag between Russian (particularly Siberian) and glo­bal science in predicting climate change and its consequences, as well as in the development and application of the mathematical models used for forecasts. Another issue that needs addressing is the approach to the problem under study within public administration, which tends to focus solely on po­tential damage from climate change. The author argues that the northward movement of the taiga enhances opportunities for the development of the Rus­sian economy.