bluuebunny/crossref_metadata_2025 huggingface dataset:
What are best practices for involving family caregivers in interventions aimed at responsive behaviour stemming from unmet needs of people with dementia in nursing homes: a scoping review
Authors: Tasseron-Dries Petra E M , Smaling Hanneke J A , Nakanishi Miharu , Achterberg Wilco P , van der Steen Jenny T
Published: December 2023

Objectives

This study aimed to determine best practices for involving family caregivers in interventions aimed at preventing and reducing responsive behaviour stemming from unmet needs, including pain.

Design

Scoping review, reported according to the Preferred Reporting Items for Systematic Reviews, Meta-Analyses extension for Scoping Reviews reporting guideline.

Data sources

PubMed, Embase, Emcare, Web of Science, COCHRANE Library, PsycINFO, Academic Search Premier and Cinahl searched up to 23 July 2023.

Eligibility criteria

Studies reporting on family involvement in interventions for nursing home residents with dementia were included.

Data extraction and synthesis

Two researchers independently extracted the data, followed by a content analysis.

Results

Of the 1486 records screened, 20 studies were included. Family caregivers were involved in interventions aimed at planning care, life review (eg, documentation of life experiences of their relative), and selecting activities for their relative. Family caregivers preferred an active role in developing optimal care for their relative. Drivers of success and barriers to family involvement centred around three themes: (1) communication between all involved; (2) prerequisites (organisational and other conditions) and (3) personal circumstances (family’s coping and skills).

Conclusion

Best practices for involving family caregivers in interventions aimed at addressing responsive behaviour in residents with dementia concerned those interventions in which family caregivers were given an important role in managing responsive behaviour. This means that, in order to achieve an active role of family caregivers in the whole care process, their needs must be taken into account.

Trial registration number

The protocol of the review was regisered at OSF;https://osf.io/twcfq
Effect of preinitiated glucose-insulin-potassium strategy for patients with undergoing planned percutaneous coronary intervention: a systematic review and meta-analysis
Authors: Liu Huiruo , Liu Rugang , Yang Zeyu , Xu Feng , Li Chuanbao
Published: December 2023

Objectives

Whether the glucose-insulin-potassium (GIK) should be used as an adjuvant therapy for ischaemic myocardial disease remains controversial nowadays reperfusion era. This meta-analysis aimed to assess the effects of preinitiated GIK for patients undergoing planned percutaneous coronary intervention (PCI).

Design

Systematic review and meta-analysis.

Data sources

PubMed, Web of science, MEDLINE, Embase, Cochrane Library and ClinicalTrials.gov were searched through 27 November 2022.

Eligibility criteria

Only randomised controlled trials involving participants preinitiated with GIK or placebo before planned PCI were included.

Data extraction and synthesis

Two independent reviewers used standardised methods to search, screen and code included trials. Risk of bias was assessed with the Cochrane tool. Pooled analysis was conducted using random or effects models according to the heterogeneity. Subgroup analyses were carried out for dosage of GIK and if with ongoing myocardial ischaemia.

Results

13 randomised controlled trials (RCTs) including 3754 participants were evaluated. We found patients preconditioned with GIK before PCI showed a significant increase in Thrombolysis in Myocardial Infarction 3 flow events after angioplasty (OR 1.59, 95% CI 1.03 to 2.46, p=0.04), also revealed improved in-hospital left ventricular ejection fraction (weighed mean difference, WMD 1.62, 95% CI 0.21 to 3.03, p=0.02) and myocardial salvage index (WMD 0.09, 95% CI 0.01 to 0.16, p=0.03). Nevertheless, no benefit was observed in all-cause mortality neither on 30-day (OR 0.81, 95% CI 0.59 to 1.11, p=0.18) nor 6 months (OR 1.02, 95% CI 0.42 to 2.46, p=0.97). Furthermore, GIK intervention was associated with higher occurrences of complications such as phlebitis (OR 10.13, 95% CI 1.74 to 59.00, p=0.01) and hypoglycaemia (OR 10.43, 95% CI 1.32 to 82.29, p=0.03), but not hyperkalaemia (OR 9.36, 95% CI 0.50 to 175.27, p=0.13), liquid overload (OR 1.02, 95% CI 0.25 to 4.13, p=0.98) or in-hospital heart failure (OR 0.42, 95% CI 0.06 to 2.96, p=0.39).

Conclusions

Our study shows preconditioning GIK exhibits myocardial reperfusion and cardiac function benefits for patients planning to receive PCI intervention, while also some complications such as phlebitis and hypoglycaemia accompany.

PROSPERO registration number

CRD42022326334.
Factors associated with COVID-19 vaccine uptake among people with type 2 diabetes in Kenya and Tanzania: a mixed-methods study
Authors: Binyaruka Peter , Mtenga Sally M , Mashasi Irene , Karugu Caroline H , Mohamed Shukri F , Asiki Gershim , Mair Frances S , Gray Cindy M
Published: December 2023

Background

People with type 2 diabetes (T2D) are at increased risk of poor outcomes from COVID-19. Vaccination can improve outcomes, but vaccine hesitancy remains a major challenge. We examined factors influencing COVID-19 vaccine uptake among people with T2D in two sub-Saharan Africa countries that adopted different national approaches to combat COVID-19, Kenya and Tanzania.

Methods

A mixed-methods study was conducted in February-March 2022, involving a survey of 1000 adults with T2D (500 Kenya; 500 Tanzania) and 51 in-depth interviews (21 Kenya; 30 Tanzania). Determinants of COVID-19 vaccine uptake were identified using a multivariate logistic regression model, while thematic content analysis explored barriers and facilitators.

Results

COVID-19 vaccine uptake was lower in Tanzania (26%) than in Kenya (75%), which may reflect an initial political hesitancy about vaccines in Tanzania. People with college/university education were four times more likely to be vaccinated than those with no education (Kenya AOR=4.25 (95% CI 1.00 to 18.03), Tanzania AOR=4.07 (1.03 to 16.12)); and people with health insurance were almost twice as likely to be vaccinated than those without health insurance (Kenya AOR=1.70 (1.07 to 2.70), Tanzania AOR=1.81 (1.04 to 3.13)). Vaccine uptake was higher in older people in Kenya, and among those with more comorbidities and higher socioeconomic status in Tanzania. Interviewees reported that wanting protection from severe illness promoted vaccine uptake, while conflicting information, misinformation and fear of side-effects limited uptake.

Conclusion

COVID-19 vaccine uptake among people with T2D was suboptimal, particularly in Tanzania, where initial political hesitancy had a negative impact. Policy-makers must develop strategies to reduce fear and misconceptions, especially among those who are less educated, uninsured and younger.
Impact of type, intensity, frequency, duration and volume of physical activity on dementia and mild cognitive impairment in older adults: protocol for a systematic review and meta-analysis
Authors: Junger Ana Lúcia , de Sousa Romeiro Amanda Maria , Noll Matias , de Oliveira Cesar , Silveira Erika Aparecida
Published: December 2023

Introduction

Worldwide, the prevalence of degenerative diseases such as dementia and mild cognitive impairment (MCI) is increasing with population ageing and increasing life expectancy. Both conditions share modifiable risk factors. Physical inactivity is one of these modifiable risk factors, and research points to the protective effect of physical activity on the incidence of dementia and MCI. However, this association tends to change according to type, intensity, frequency, duration and volume of physical activity. Furthermore, it remains unclear which of these characteristics offers the greatest protective effect. Therefore, this study aims to evaluate the impacts of different types, intensities, frequencies, duration and volume of physical activity on dementia and cognitive decline in older adults.

Methods and analysis

The search will be carried out from October 2023, using the following databases: PubMed, Embase, Scopus, CINAHL and Web of Science. Cohort studies with a follow-up time of 1 year or longer that have investigated the incidence of dementia and/or MCI in older adults exposed to physical activity will be included. There will be no limitations on the date of publication of the studies. Studies published in English, Spanish or Portuguese will be analysed. Two researchers will independently screen the articles and extract the data. Any discrepancies will be resolved by a third reviewer. Association measures will be quantified, including OR, HR, relative risk and incidence ratio, with a 95% CI. If the data allow, a meta-analysis will be performed. To assess the methodological quality of the selected studies, the Grading of Recommendations, Assessment, Development and Evaluations instrument, and the Downs and Black instrument to assess the risk of bias, will be used.

Ethics and dissemination

Ethical approval is not required. The results will be submitted for publication in a peer-reviewed journal.

PROSPERO registration number

CRD42023400411.
Difference in tissue temperature change between two cryoballoons
Authors: Hayashi Takahiro , Hamada Kohei , Iwasaki Kiyotaka , Takada Jumpei , Murakami Masato , Saito Shigeru
Published: December 2023

Background

Cryoballoon ablation, especially Arctic Front Advance Pro (AFA-Pro) (Medtronic, Minneapolis, Minnesota, USA), has been widely recognised as a standard approach to atrial fibrillation (AF). Recently, Boston Scientific has released a novel cryoballoon system (POLARx). Despite comparable acute clinical outcomes of these two cryoballoons, the recent study reported a higher complication rate, especially for phrenic nerve palsy, with POLARx. However, their impact on biological tissue remains unclear.

Objective

The purpose of our study is to evaluate temperature change of biological tissue during cryoablation of each cryoballoon using a porcine experimental model.

Method

A tissue-based pulmonary vein model was constructed from porcine myocardial tissue and placed on a stage designed to simulate pulmonary vein anatomy and venous flow. Controlled cryoablations of AFA-Pro and POLARx were performed in this model to evaluate the tissue temperature. A temperature sensor was set behind the muscle and cryoballoon ablation was performed after confirming the occlusion of pulmonary vein with cryoballoon.

Results

The mean tissue nadir temperature during cryoablation with AFA-Pro was −41.5°C±4.9°C, while the mean tissue nadir temperature during cryoablation with POLARx was −58.4°C±5.9°C (p<0.001). The mean balloon nadir temperature during cryoablation with AFA-Pro was −54.6°C±2.6°C and the mean balloon nadir temperature during cryoablation with POLARx was −64.7°C±3.8°C (p<0.001).

Conclusion

POLARx could freeze the biological tissue more strongly than AFA-Pro.
Error compensation of a 2TPR&2TPS parallel mechanism based on particle swarm optimization
Authors: He Chaoyin , Chen Mingfang , Liang Hongjian , Zhang Yongxia , Chen Zhongping
Published: December 2023

This paper solves the problem of the precise compensation of the pose error of a 2TPR&2TPS parallel mechanism. First, the inverse solution of the mechanism is solved, the error source of the mechanism is analyzed, and a closed-loop vector method error model based on the inverse solution is established. Then, the ball screw commutation gap is measured with a high-precision grating ruler, and a laser tracker is used to measure the comprehensive position error of the mechanism under the set trajectory (circle). Finally, an error compensation algorithm based on the particle swarm algorithm is constructed, the measured trajectory data are substituted into the compensation algorithm, the position accuracy of the mechanism is significantly improved, and the compensation effect is remarkable. The compensation algorithm has good versatility, is simple and feasible, and can be applied to the error compensation of various mechanisms.
The Effect of Platform Data Quality on Tax Compliance in Digital Economy: A Multiagent Based Simulation
Authors: Jin Peng , Feng Zhangwei , Li Guiping
Published: December 2023

The expeditious development of the digital economy has posed critical challenges for tax compliance. Recent reforms and technological changes, such as the emergency of platform data sharing, perform as potential instruments to potentially solve the tax compliance issue in the digital economy. This article innovatively combines tax compliance and digital economy taxation and proposes an expected utility theory model and a multiagent simulation model of tax compliance in the context of the digital economy, incorporating an important impact factor—platform data quality. In addition, the discrepancy and applicable conditions of three audit modes have been first compared and analyzed in this research: unconstrained signal audit, constrained random audit, and constrained signal audit. Applying computational experiments, this paper further investigates the effect of platform data quality on tax compliance in the digital economy. The key findings include: (1) the signal role of platform data is affected by three factors—the quality of platform data, the audit intensity and audit rate; (2) the signal role of platform data can be negative in given situations; and (3) the tax compliance rate varies in three different audit modes, which depend on the platform data quality, audit rate, and audit intensity. Based on the findings, this article provides policy recommendations on tax collection and management in digital economy.
Hydrogeological Challenge for Coal Bed Methane (CBM) Production in Structurally Complex Reservoirs: Case Study for the Synclines of Umbita and Checua-Lenguazaque, Colombia
Authors: Rivera L. E. , Mariño J. E.
Published: December 2023

Colombia is advancing toward pilot production of coal bed methane (CBM) at the Umbita syncline (US) and Checua-Lenguazaque syncline (CLS) in the Cundiboyacense plateau of the Eastern Cordillera. Although attractive, the development of CBM resources remains hydrogeologically challenging due to infinite acting aquifer (IAA) conditions, a sustainable production of ineffective water, which removal is critical to achieve methane desorption. Here, we assessed the implications of IAA on methane production prior to pilot development by comparing single-phase flow numerical simulations of the prospects. The results suggest IAA would extend the dewatering period in the Umbita syncline up to 20 years to potentially compromise the commercial recovery of methane. The Chequa-Lenguasaque, on the other hand, appears to have reached the phase of production of effective water; therefore, it is deemed as the most attractive prospect for pilot testing the production of CBM in Colombia.
Cognitive Theory of Mind Deficit Associated with Executive Dysfunction in Cervical Dystonia
Authors: Kupper Christin , Lochmann Hannah , Wyrobnik Michelle , Steiner Oliver , Klostermann Fabian
Published: December 2023

Introduction. Cervical dystonia (CD) is viewed as a circumscribed movement disorder. However, beyond motor symptoms, it can imply subtle cognitive change, among others with respect to theory of mind (ToM) capacities. Here, affective and cognitive ToM performances and potential relations to other mental functions were investigated to refine the concept of social cognitive dysfunction in CD. Methods. 20 persons with CD were clinically assessed, together with 20 healthy controls engaged in overview cognitive testing, executive function (EF) tasks, and the Faux Pas Recognition Test (FPRT) as well as the Reading the Mind in the Eyes Tests (RMET) addressing cognitive and affective ToM functions, respectively. Results. Persons with CD showed lower cognitive, but not affective ToM performance than controls. Further, they had abnormally low word production in verbal fluency (VF) tasks, imposing high EF demands. Generally, ToM performance correlated with VF and, further, with the decreased quality of life score in persons with CD. Conclusion. Cognitive ToM deficits seem to occur in the context of executive dysfunction in CD. They belong to an underrecognized spectrum of nonmotor symptoms of likely clinical relevance.
A Multipolarized Traveling-Wave Series-Fed Antenna Array Based on Patch
Authors: Guan Xin , Xue Zhenghui , Ren Wu , Li Weiming
Published: December 2023

In this paper, a simple broadband multipolarized traveling-wave series-fed antenna array is proposed. The radiation unit cells are multiple squares. The square unit cell will change between circular polarized (CP) and linear polarized (LP) through a reasonable feeding mode. By adjusting the equivalent length of the unit cell, the

Q

value of the antenna can be reduced, resulting in the increase of the bandwidth of the array. The array consists of seven-unit cells and dual-port feeding. The unit cells which are connected by a microstrip line are arranged in a circular array. A reasonable layout of unit cells can achieve good port isolation of the array. The polarization performance of the array antenna is the same as that of the unit cell. The antenna is fabricated and measured. The measured results are consistent with the simulated results.
Suppression of NK Cell Activation by JAK3 Inhibition: Implication in the Treatment of Autoimmune Diseases
Authors: Wu Wai Chung , Shiu Carol , Tong Tak Keung , Leung Shui On , Hui Chin Wai
Published: December 2023

Natural killer (NK) cell is an essential cytotoxic lymphocyte in our innate immunity. Activation of NK cells is of paramount importance in defending against pathogens, suppressing autoantibody production and regulating other immune cells. Common gamma chain (γc) cytokines, including IL-2, IL-15, and IL-21, are defined as essential regulators for NK cell homeostasis and development. However, it is inconclusive whether γc cytokine-driven NK cell activation plays a protective or pathogenic role in the development of autoimmunity. In this study, we investigate and correlate the differential effects of γc cytokines in NK cell expansion and activation. IL-2 and IL-15 are mainly responsible for NK cell activation, while IL-21 preferentially stimulates NK cell proliferation. Blockade of Janus tyrosine kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway by either JAK inhibitors or antibodies targeting γc receptor subunits reverses the γc cytokine-induced NK cell activation, leading to suppression of its autoimmunity-like phenotype in vitro. These results underline the mechanisms of how γc cytokines trigger autoimmune phenotype in NK cells as a potential target to autoimmune diseases.
To Quiesce or Senesce, That Is the Question for Dedifferentiated Liposarcoma
Authors: Weiss Mia C. , Eulo Vanessa , Van Tine Brian A.
Published: December 2023

Dedifferentiated liposarcoma (DDLPS) has an appealing therapeutic target due to its CDK4 amplification on chromosome 12q. The understanding of geroconversion from quiescent cells to senescent cells defines a patient's response to CDK4 inhibitors. This new observation will inform not only the ongoing phase III clinical trial of abemaciclib, but all future clinical trials in DDLPS.

See related article by Gleason et al., p. 703
Table S1 from Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors
Authors: Juarez Dennis , Buono Roberta , Matulis Shannon M. , Gupta Vikas A. , Duong Madeleine , Yudiono Jacob , Paul Madhuri , Mallya Sharmila , Diep Grace , Hsin Peter , Lu Alexander , Suh Sang Mi , Dong Vy M. , Roberts Andrew W. , Leverson Joel D. , Jalaluddin Muhammad , Liu Zhuangzhuang , Bueno Orlando F. , Boise Lawrence H. , Fruman David A.
Published: December 2023

Supplementary Table S1 presents statistical analysis of pooled clinical trial data on R/R MM patient response to venetoclax treatment, comparing statin users to non-statin users.
Figure S2 from Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors
Authors: Juarez Dennis , Buono Roberta , Matulis Shannon M. , Gupta Vikas A. , Duong Madeleine , Yudiono Jacob , Paul Madhuri , Mallya Sharmila , Diep Grace , Hsin Peter , Lu Alexander , Suh Sang Mi , Dong Vy M. , Roberts Andrew W. , Leverson Joel D. , Jalaluddin Muhammad , Liu Zhuangzhuang , Bueno Orlando F. , Boise Lawrence H. , Fruman David A.
Published: December 2023

Supplementary Figure 2 contains PFS data from venetoclax clinical trials in MM
Are Traumatic Disintegration, Detachment, and Dissociation Separate Pathogenic Processes Related to Attachment Trauma? A Working Hypothesis for Clinicians and Researchers
Authors: Farina Benedetto , Imperatori Claudio
Published: December 2023

Background: Despite its high prevalence in all psychiatric disorders and its widely demonstrated clinical relevance as a marker of both clinical severity and poorer treatment response, a scientifically validated definition of dissociation remains controversial, and the understanding of its pathogenesis is still somewhat lacking. Furthermore, although most clinicians commonly refer to dissociation as a single unitary concept, the empirical evidence strongly supports the paucity of a one-dimensional approach to dissociation. Summary: Resonating with the clinical and neuroscientific data on this topic, this article aimed to provide a working hypothesis, suggesting that the wide variety of psychopathological phenomena that are currently improperly lumped into the category of dissociation are in fact produced by at least three different pathogenic processes involved in developmental trauma, namely, traumatic disintegration, detachment responses, and dissociation. Key Messages: This hypothesis should, therefore, be considered a starting point for a better understanding of the complex manifestations and processes that currently overly, attributed to dissociation per se.
Relation between the Epicardial Fat Thickness and the Cardiac Conduction System in Children and Adolescents with Diabetes
Authors: Raafat Shaymaa , Ahmed Reham , Mowafi Ihsan , Adel Hani
Published: December 2023

Introduction: Atherosclerosis in patients with type 1 diabetes starts early in childhood with subclinical abnormalities. The epicardial fat thickness (EFT) is a novel method for detecting these early changes. Furthermore, electrocardiographic markers may be altered in patients with diabetes owing to early cardiovascular changes. This study aimed to determine the relationship between EFT and electrocardiographic markers in children with type 1 diabetes mellitus. Methods: Children with type 1 diabetes who were followed up at the Alexandria University Children’s Hospital Diabetes Clinic were enrolled in this study. The study recruited three groups of participants, including 20 patients with a diabetes duration of less than 5 years, 20 patients with a diabetes duration of 5 years or more, and 20 healthy controls. All participants were evaluated with emphasis on anthropometric measurements, fasting blood glucose levels, and lipid profile. HbA1c levels were measured in the cohort with diabetes. All participants underwent electrocardiography for measurement of P-wave dispersion, corrected QT interval and its dispersion, and Tp-e measurement. Echocardiography was performed to measure the EFT. Results: Among all participants, EFT was significantly higher in children with a diabetes duration of ≥5 years (p = 0.009). Furthermore, P-wave dispersion was significantly prolonged in children with diabetes compared to that in nondiabetics (p = 0.041). There was a statistically significant correlation between EFT and P-wave dispersion in patients with diabetes aged ≥5 years (p = 0.021). Conclusions: Measurement of EFT by echocardiography is a novel and easy way to predict early cardiovascular changes in children with diabetes, including conduction system disorders.
C-X-C Motif Chemokine Ligand 1 Promotes Colitis by Modulating the Gut Microbiota
Authors: Zhao Hang , Li Wenhua , Zhou Xin , Pan Liang , Feng Yun , Gao Pingyu , Ji Jie , Zhang Huanyan , Zhao Kai , Wang Chi , Lu Zhanjun
Published: December 2023

Introduction: C-X-C motif chemokine ligand 1 (CXCL1) is a potent neutrophil chemoattractant that plays a pivotal role in recruiting neutrophils during inflammatory conditions. This study explored the role of CXCL1 in modulating the gut microbiota, influencing neutrophil infiltration, and contributing to the development of colitis. Methods: We employed quantitative PCR to assess CXCL1 expression in colon samples. A mouse model of dextran sulfate sodium (DSS)-induced colitis was utilized to explore the progression of colitis in wild-type (WT) and CXCL1-deficient (CXCL1−/−) mice. Results: Colitis attenuation was evident in CXCL1−/− mice. Significant alterations were observed in the gut microbiome, as revealed by 16S rRNA gene sequencing. Furthermore, CXCL1−/− mice exhibited reduced gut permeability and diminished endotoxin levels in peripheral blood following DSS treatment compared to WT mice. In response to DSS treatment, WT mice showed a clear increase in neutrophil infiltration, while CXCL1−/− mice exhibited lower levels of infiltration. Fecal microbiota transplantation (FMT) using stools from CXCL1−/− mice alleviated DSS-induced colitis. Interestingly, FMT from patients with colitis increased CXCL1 and Ly6G expression in the colons of gut-sterilized mice. Clinical data analysis revealed elevated CXCL1 and CD15 expression in patients with colitis, with a positive correlation between the severity of colitis and the expression of CXCL1 and CD15. Conclusion: These findings shed light on the pivotal role of CXCL1 in promoting colitis by modulating the gut microbiota.
POST-SIEGE GENOTOXIC HAZARDS IN LAKE LANAO, PHILIPPINES BY MICRONUCLEUS ASSAY
Authors: Abamo Fema , Ferranco Ed Lucille May , Villarino Annabella
Published: December 2023

Massive war pollutants brought by Marawi Siege in the Philippines have contaminated the city environs and the surrounding ancient Lake Lanao. Munition residues including heavy metals are reportedly genotoxic hence this study was conducted to determine the post-siege genotoxic hazards posed by the munition pollutants through micronucleus (MN) assay on the slow-moving edible gastropod snails Vivipara angularis Muller (locally known as “suso”) thriving in the lake. MN, a biomarker of genotoxicity was examined and counted in the hemocytes of exposed juvenile and adult snails. Results revealed that MN frequencies (no. of MN/1000 hemocytes) were significantly higher in snails sampled in Lake Lanao lakeshores than in the reference site Lake Dapao. Among adult samples, there was a decreasing trend of MN frequencies with increasing distance from lakeshore fronting warzone ‘ground zero’ where the battle was heaviest (site A) to sampling sites away from it: sites B, C, and D (Lake Dapao) which are 8.15 km, 24.41 km, and 34.45 km, respectively. Moreover, varied patterns of micronucleation were observed between age groups and sites, i.e., in all sites except C, adults had greater MN counts than juveniles which were significant in site A only. Unexpectedly juveniles displayed significantly high MN counts than adults in site C. The elevated MN frequencies in the snail hemocytes exposed to war pollution could be attributed to genotoxic munition residues eroded and washed into the lake water. Moreover, heavy metals which are common components of weaponries were also detected in the snail muscles, although at concentrations within safe levels but continued consumption may be cautioned to avoid biomagnification. Other genotoxins must be present in site C other than munition residues predisposing the juvenile snails. The results are baseline data on the MN frequencies in V. angularis exposed to war pollutants in Lake Lanao which need further investigation. Post-siege genotoxic hazards in the lake by MN assay cannot be ignored, thus local leaders must be informed of the results for possible intervention to protect the health and well-being of the community.
EFFECT OF THINNING ON GROWTH AND WOOD PRODUCTION OF NATURALLY REGENERATED 8-YEAR-OLD ACACIA MANGIUM WILLD. PLANTATION ON ABANDONED MINING AREA, SOUTHERN THAILAND
Authors: Wongprom Jetsada , Maelim Somporn , Chandaeng Wasan , Teejuntuk Sakhan , Sommeechai Monthathip , Duangnamon Decha
Published: December 2023

Thinning is an important practice for promoting growth and maintaining forest plantation for wood production from the remaining trees. In this study, thinning was carried out in a naturally regenerated 8-year-old Acacia mangium plot in the Phangnga Forestry Research Station. Three thinning schemes, with 175 (T1), 300 (T2) and 600 (T3) remaining trees/ha, were compared with the control (no thinning) of 831 trees/ha. The diameter at breast height (DBH) and height (H) of the trees were measured. The differences in growth, current annual increment (CAI), aboveground biomass, and stem volume (V) were analyzed. We observed that the thinning of A. mangium increased the growth rate, with the DBH being clearly affected by thinning. CAIDBH increased significantly, with the DBH class of thinned A. mangium plots also improving after thinning. The stem volume and aboveground biomass of T3 plot was similar to the control plot after thinning. In addition, the number of large saw logs was the highest in T3 plot. The large saw logs can be used for multi-utilization and have a high value. These results suggest that thinning can promote stem growth, and increase the proportion of large saw logs in naturally regenerated A. mangium stands.
BRYOPHYTE DIVERSITY AND ATMOSPHERIC POLLUTION IN A RESIDENTIAL AREA AND AN INDUSTRIAL URBAN FOREST IN JAKARTA, INDONESIA
Authors: Putrika Afiatry , Salamah Andi , Atria Mega , Hendrayanti Dian , Winarni Nurul Laksmi , Purba Eliza Pricilia , Tsabitudinillah Sarah , Ariyanti Nunik Sri
Published: December 2023

Bryophytes are nonvascular plants that have simple structures that are sensitive to environmental changes, and they can, therefore be used as indicators of air quality. The presence of bryophytes in disturbed urban ecosystems, such as residential and industrial areas, indicates that their structures have adapted to survive in such areas. The objective of this study was to compare the bryophyte diversity and air quality indices between a residential area and an industrial area in Jakarta. The research was conducted in the Bona Indah residential area in South Jakarta and the Jakarta Industrial Estate Pulogadung (JEIP) urban forest. Sampling was carried out using the transect method in the residential area and the quadratic method in the urban forest on three different substrates, namely rocks or concrete, soil and tree trunks. The percentage of the epiphytic bryophyte cover was measured using a 10 × 10 cm subplot. Voucher specimens were stored at the Herbarium UI DEP and Herbarium IPB. Twenty-one species of moss and three species of liverwort were found in the two locations. Bryophytes were found on all the substrates in the residential area, but in the urban forest, they were found only on tree trunks and rock/cement substrates. Based on the Shannon–Wiener Index, although both locations had moderate bryophyte diversity, the residential area’s bryophyte diversity was higher than that of the urban forest. The index of atmospheric purity in the residential area was 4.3, indicating a high level of pollution, and it was 0.3 in the urban forest, showing that it was also very polluted.
Electrophysiological Characteristics and Ablation Outcomes in Patients With Catecholaminergic Polymorphic Ventricular Tachycardia
Authors: Shen Lishui , Liu Shangyu , Hu Feng , Zhang Zhenhao , Li Jiakun , Lai Zihao , Zheng Lihui , Yao Yan
Published: December 2023

Background

Catheter ablation of premature ventricular contractions (PVCs) that trigger polymorphic ventricular tachycardia (PVT) or ventricular fibrillation has been reported as a novel therapy to reduce the syncope events in patients with catecholaminergic PVT, whereas the long‐term ablation outcome and its value in improving exercise‐induced ventricular arrhythmias remain unclear.

Methods and Results

Fourteen consecutive selected patients with catecholaminergic PVT (mean±SD age, 16±6 years; 43% male patients) treated with maximum β‐blockers with no possibility of adding flecainide were prospectively enrolled for catheter ablation. The primary end point was syncope recurrence, and the secondary end point was the reduction of the ventricular arrhythmia score during exercise testing. Twenty‐six PVT/ventricular fibrillation–triggering PVCs were identified for ablation. The trigger beats arose from the left ventricle in 50% of the cases and from both ventricles in 36% of the cases. Purkinje potentials were observed at 27% of the targets. After a mean follow‐up of 49 months after ablation, 8 (57%) patients were free from syncope recurrence. Ablation of trigger beat significantly reduced the syncope frequency (mean±SD, 4.3±1.6 to 0.5±0.8 events per year;
P
<0.001) and improved the ventricular arrhythmia scores at the 3‐month (5 [range, 3–6] to 1.5 [range, 0–5];
P
=0.002) and 12‐month (5 [range, 3–6] to 2 [range, 0–5];
P
=0.014) follow‐ups. The induction of nontriggering PVCs postablation was closely associated with syncope recurrence (hazard ratio, 6.8 [95% CI, 1.3–35.5];
P
=0.026).

Conclusions

Catheter ablation of PVT/ventricular fibrillation–triggering PVCs in patients with catecholaminergic PVT who cannot receive flecainide treatment seems to be a safe and feasible adjunctive treatment that may reduce the syncope burden and improve exercise‐related ventricular arrhythmias. Induction of nontriggering PVCs after ablation is associated with a higher risk of syncope recurrence.
A Newly Identified Treatise on the Tables of Marseilles (Twelfth Century) and Its Non-Ptolemaic Planetary Theory
Authors: Nothaft C. Philipp E.
Published: December 2023

Two Latin manuscripts in Oxford and Florence preserve diverging recensions of a previously unnoticed astronomical treatise beginning Infra signiferi poli regionem (Oxford recension) or Circulorum alius est sub quo (Florence recension). It can be shown that this anonymous text was originally intended to accompany the Tables of Marseilles in Raymond of Marseilles’s twelfth-century Liber cursuum planetarum (ca. 1141). While the core tables for planetary longitudes in this set were founded on Ptolemy’s kinematic models, as known from the Almagest, this new source frequently deviates from the Ptolemaic norm, for instance by explicitly rejecting an epicyclic explanation of planetary stations and retrogradations. In place of the latter, it argues in favour of a heliodynamic theory inspired by Roman sources such as Pliny, which underwent certain developments in the works of twelfth-century Latin writers such as William of Conches. Rather than being wholly exceptional, these features are indicative of a degree of disconnect between planetary theory and computational practice in twelfth-century Latin astronomy, which is also detectable in other sources from this period.
Visual Narratives of Boxer-era China: Two German Photo Albums of the Early 1900s
Authors: Klein Thoralf
Published: December 2023

In this article, I examine two ‘semi-public’ German photo albums composed in the immediate aftermath of the international military intervention in China in 1900–01 known as the Boxer War. One was compiled by two members of the German East Asian Expeditionary Corps, Dr Wang and Lieutenant Freiherr von Meerscheidt-Hüllessem, the other by the incoming German minister to Beijing, Alfred von Mumm. I will begin by developing a narrative theory of the photo album. I will use this to demonstrate how the two albums visually (re-)construct a multifaceted journey through space and time in which political and military themes blend with a cultural gaze on China’s architecture as well as its people. The albums are thus situated at the intersection between imperialist intervention, cultural ethnography and modern (foreign) tourism in China. And they reflect various power differentials: not just the one between imperialist agents and victims but equally that between ethnographers and the people they study, as well as the one that characterises modern tourism.
Conversion of mycotoxin-contaminated maize by black soldier fly larvae into feed and fertilizer
Authors: Gold M. , Niermans K. , Jooste F. , Stanford L. , Uwamahoro F. , Wanja M. , Veldkamp T. , Sanderson A. , Dos Santos Nunes V. , Mathys A. , van der Fels-Klerx H.J. , Hoek-van den Hil E.F. , Nishimwe K.
Published: December 2023

Globally, large amounts of various crops such as cereals, oilseeds, nuts and spices are contaminated with mycotoxins during pre-harvest, postharvest handling, processing and/or storage. Mycotoxin contamination results into economic and health issues, and valorisation options of contaminated crops are urgently needed. The aim of this research was to evaluate whether quality feed and fertilizer can be safely produced from naturally mycotoxin contaminated crops using black soldier fly larvae (BSFL, Hermetia illucens L.) under realistic field conditions in East Africa. Naturally mycotoxin contaminated maize (corn; Zea mays L.) was used as a model due its prevalence as food and feed and utilized by BSFL together with local agri-food by-products at a research facility in Rwanda. To assess the influence of the initial maize mycotoxin contamination and maize inclusion, larval diets with three mycotoxin contamination levels and two maize inclusion levels were tested. BSFL were tolerant against the high mycotoxin concentrations (e.g. 99.4 μg aflatoxin B1 kg dry mass-1) as the presence of mycotoxins in the substrate did not affect BSFL mass at harvest. Product safety was assessed by quantifying the presence of 38 common and emerging mycotoxins and metabolites in the maize, substrates and BSFL products (e.g. larvae and frass). The results show that it is possible to produce feed and fertilizer with BSFL considered safe within the European Union and East African legal limits with maize contaminated with mycotoxins typical for East Africa. Thereby, this research works towards the safe recycling of nutrients from mycotoxin contaminated maize within the food system in East Africa and beyond.
Precedents in Peacemaking
Authors: Ehrhardt Andrew
Published: December 2023

This article examines the peace settlements of 1815, 1919, and 1945 with an eye towards drawing out certain insights for current conflicts, specifically the Russo-Ukrainian War. Among the points covered in this article are the position and capability of military forces, the alignments and agreements which take place before and after the main peace negotiations, the assumptions around how long a settlement might last, the influence of existing social and intellectual currents which surround the statesmen and women negotiating peace, and the importance of individual personalities in arriving at a lasting and stable peace. How long the war between Russia and Ukraine will last is uncertain, but it is more likely than not that policymakers in Moscow and Kiev, as well as their counterparts in capitals across Europe and beyond, will consider eventual negotiations. This article provides ideas and approaches from some of the most notable precedents in the 19th and 20th centuries, as a way of stimulating thinking about a future peace settlement.
Postprocessing of Ensemble Weather Forecasts Using Permutation-Invariant Neural Networks
Authors: Höhlein Kevin , Schulz Benedikt , Westermann Rüdiger , Lerch Sebastian
Published: December 2023

Statistical postprocessing is used to translate ensembles of raw numerical weather forecasts into reliable probabilistic forecast distributions. In this study, we examine the use of permutation-invariant neural networks for this task. In contrast to previous approaches, which often operate on ensemble summary statistics and dismiss details of the ensemble distribution, we propose networks that treat forecast ensembles as a set of unordered member forecasts and learn link functions that are by design invariant to permutations of the member ordering. We evaluate the quality of the obtained forecast distributions in terms of calibration and sharpness and compare the models against classical and neural network–based benchmark methods. In case studies addressing the postprocessing of surface temperature and wind gust forecasts, we demonstrate state-of-the-art prediction quality. To deepen the understanding of the learned inference process, we further propose a permutation-based importance analysis for ensemble-valued predictors, which highlights specific aspects of the ensemble forecast that are considered important by the trained postprocessing models. Our results suggest that most of the relevant information is contained in a few ensemble-internal degrees of freedom, which may impact the design of future ensemble forecasting and postprocessing systems.
Supercell Thunderstorms in Complex Topography—How Mountain Valleys with Lakes Can Increase Occurrence Frequency
Authors: Feldmann Monika , Rotunno Richard , Germann Urs , Berne Alexis
Published: December 2023

This study investigates the effects of lakes in mountainous terrain on the evolution of supercell thunderstorms. With a newly developed radar-based, mesocyclone-detection algorithm, a recent study has characterized the occurrence and evolution of supercell thunderstorms in the Swiss Alpine region. That study highlights the influence of orography on both storm intensity and occurrence frequency. To disentangle the different influential factors, an idealized modeling framework is established here using the mesoscale model CM1. The modeling scenarios are based on a high-CAPE environment with unidirectional shear, where a warm bubble serves to initiate the convection. Mimicking the environment of the southern Prealps in central Europe, scenarios with a high mountain ridge, valleys, and lakes are explored. The effect on the supercells of the slopes, high-altitude terrain, and moisture sources emphasizes the highly localized nature of terrain effects, leading to a heterogeneous intensity life cycle with transitory enhancement and weakening of the supercell. The dynamic and thermodynamic impact of mountain valleys with lakes increases the range of atmospheric conditions that supports supercellular development through horizontal vorticity production, increased storm relative helicity, and higher moisture content. This influence results in a systematic location dependence of the frequency, intensity, and lifetime of supercells, as also found in observations.
Rural Melanoma Patients Have Less Surgery and Higher Melanoma-Specific Mortality
Authors: Hernandez Alexandra E. , Benck Kelley N. , Huerta Carlos T. , Ogobuiro Ifeanyichukwu , De La Cruz Ku Gabriel , Möller Mecker G.
Published: December 2023

Background

Melanoma causes most skin cancer–related deaths, and disparities in mortality persist. Rural communities, compared to urban, face higher levels of poverty and more barriers to care, leading to higher stage at presentation and shorter survival in melanoma. To further evaluate these disparities, we sought to assess the association between rurality and melanoma cause-specific mortality and receipt of recommended surgery in a national cohort.

Methods

Patients with primary non-ocular, cutaneous melanoma from the SEER database, 2000-2017, were included. Outcomes included melanoma-specific survival and receipt of recommended surgery. Rurality was based on Rural-Urban Continuum Codes. Variables included age, sex, race, ethnicity, income, and stage. Multivariate regression models assessed the effect of rurality on survival and receipt of recommended surgery.

Results

103,606 patients diagnosed with non-ocular cutaneous primary melanoma met criteria during this period. 93.3% ( n = 96620) were in urban areas and 6.7% ( n = 6986) were in rural areas. On multivariate regression controlling for age, sex, race, ethnicity, and stage patients living in a rural area were less likely to receive recommended surgery (aOR .52, 95% CI: .29-.90, P = .02) and had increased hazard of melanoma-specific mortality (aHR 1.19, 95% CI: 1.02-1.40, P = .03) even after additionally controlling for surgery receipt.

Conclusion

Using a large national cohort, our study found that rural patients were less likely to receive recommended surgery and had shorter melanoma cause-specific survival. Our findings highlight the importance of access to cancer care in rural areas and how this ultimately effects survival for these patients.
Fragmentation of Care After Geriatric Trauma: A Nationwide Analysis of outcomes and Predictors
Authors: Gogna Shekhar , Zangbar Bardiya , Rafieezadeh Aryan , Hanna Kamil , Shnaydman Ilya , Con Jorge , Bronstein Matthew , Klein Joshua , Prabhakaran Kartik
Published: December 2023

The health care system for the elderly is fragmented, that is worsened when readmission occurs to different hospitals. There is limited investigation into the impact of fragmentation on geriatric trauma patient outcomes. The aim of this study was to compare the outcomes following readmissions after geriatric trauma. The Nationwide Readmissions Database (2016-2017) was queried for elderly trauma patients (aged ≥65 years) readmitted due to any cause. Patients were divided into 2 groups according to readmission: index vs non-index hospital. Outcomes were 30 and 180-day complications, mortality, and the number of subsequent readmissions. Multivariable logistic regression was performed to analyze the independent predictors of fragmentation of care. A total of 36,176 trauma patients were readmitted, of which 3856 elderly patients (aged ≥65 years) were readmitted: index hospital (3420; 89%) vs non-index hospital (436; 11%). Following 1:2 propensity matching, elderly with non-index hospital readmission had higher rates of death and MI within 180 days ( P = .01 and .02, respectively). They had statistically higher 30 and 180-day pneumonia ( P < .01), CHF ( P < .01), arrhythmias ( P < .01), MI ( P < .01), sepsis ( P < .01), and UTI ( P < .01). On multivariable binary logistic regression analysis, pneumonia (OR 1.70, P = .03), congestive heart failure (CHF) (OR 1.80, P = .03), female gender (OR .72, P = .04), and severe Head and Neck trauma (AIS≥3) (OR 1.50, P < .01) on index admission were independent predictors of fragmentation of care. While the increase in time to readmission (OR 1.01, P < .01) was also associated independently with non-index hospital admission. Fragmented care after geriatric trauma could be associated with higher mortality and complications.
Development and Validation of Tool for Assessment of Knowledge About Childhood Hypertension Among Final Year Medical Student
Authors: Yadav Yogendra Singh , Mamidi Sreeharshini , Joshi Ankur , Kumar Amber , Malik Shikha , Maheshwari Mahesh , Bhatt Girish Chandra
Published: December 2023

Childhood hypertension (HTN) is becoming one of the most important health concerns in children, and it is the most important predictor of adult HTN. The objective was to assess the level of knowledge and to develop and validate questionnaires about childhood HTN among final-year medical students. This facility-based cross-sectional study was conducted from January 2018 to September 2018 in 5 teaching hospitals of Central India. A total of 383 interviews were conducted by non-probability purposive sampling using a validated tool. Exploratory factor analysis was used to assess the validity of the questionnaire, and internal consistency of items was assessed with Cronbach α. A total of 26 items were finalized through consensus. The Kaiser–Meyer–Olkin (KMO) measure of sample adequacy was measures of sampling adequacy (MSA) = 0.83, and Bartlett’s test of sphericity was (x2 = 15.89, P = .014). This study shows that the tool developed had acceptable validity and reliability to assess the knowledge about childhood HTN among undergraduate medical students.