bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementing Response to Intervention (RtI) in a Juvenile Detention Center Using Action Research
Authors:   Fort Hays State University Virtual College, Coker David C.
Published: November 2021

While proponents claimed Response to Intervention (RtI) improved student learning and prevented failure, there was an absence of research in effectiveness. Applying action research within a case study, there was an investigation into the process of reforming and improving RtI within a short-term juvenile detention center in the Midwest of the United States for students in grades 5-12. Using the conceptual framework of adaptive leadership, there was an analysis of policies and procedures, observations, interviews, and student work. RtI as a stand-alone program revealed many teachers lacked evidence-based instructional methods and alternative teachers lacked content knowledge, making implementation difficult. Within the action research method, role ambiguity caused problems with fidelity, with the need to infuse strategic leadership with action research when teachers’ sense of self and professional were challenged.
First data on plasmodial slime moulds (Myxomycetes = Myxogastrea) of Rdeysky Nature Reserve (Novgorod Region, Russia)
Authors: Borzov N. I. , Bortnikov F. M. , Matveev A. V. , Gmoshinskiy V. I.
Published: November 2021

The results of the first study of the species diversity of myxomycetes of the Rdeysky State Nature Reserve are presented. The 201 field specimens of sporophores belonging to 56 morphospecies from 27 genera, ten families, and six orders were collected from September 30 to October 5, 2020. Fifty-two species of these were new for the Novgorod Region. The most common species at the reserve were Arcyria affinis, Hemitrichia calyculata, Lycogala epidendrum, Metatrichia vesparia, Physarum album, Trichia decipiens, and T. varia. Additionally, detailed morphological descriptions of two rare species Amaurochaete trechispora and Trichia crateriformis are given.
Anacamptodon latidens (Bryophyta, Amblystegiaceae), a new species for Europe
Authors: Ignatova E. A. , Fedorova A. V. , Ignatov M. S.
Published: November 2021

Anacamptodon latidens is discovered in the Russian Caucasus as a species new to the territory of Europe as the latter is defined in recent Checklists. Previously these Caucasian specimens were reported as A. splachnoides, hence the latter species is excluded from moss flora of Russia, although it occurs in Georgia in the Caucasus close to the Russian border. Problems with the morphological delimitation between A. latidens and A. splachnoides are discussed, appearing to be more complicated than it was considered previously. The analysis of DNA sequence data has been undertaken and revealed that Anacamptodon from Dagestan is A. latidens.
COVID-19 Pandemisinde Bilgi Edinme Kaynakları, Medya Kullanım Alışkanlıkları ve Aşıya Yönelik Tutumlar
Authors: GENÇ Çağlar
Published: November 2021

Günümüz teknoloji yoğun ortamda bilişim ve iletişim teknoloji ve uygulamalarında yaşanan yeniliklerle birlikte insanların bilgiye olan erişimi de büyük bir hızla artmıştır. Erişim olanaklarının artması ile birlikte insanlar artık ilgi alanlarına giren konularda pek çok farklı bilgi kaynağına kolayca ulaşabilmektedir. Bilgilerin hangi kaynaktan elde edildiği ve ne kadar güvenilir olduğu üzerinde önemle durulması gereken bir husustur. Çalışmanın amacı, COVID-19 pandemisi ile ilgili bilgi edinmede referans gruplarına ve medyaya yönelik güveni, COVID-19 hastalığına yönelik algıyı ve COVID-19 aşısına yönelik tutumları ortaya çıkarmaktır. Çalışma çevrimiçi anket yöntemi ile gerçekleştirilmiştir. Olasılıklı olmayan örnekleme yöntemlerinden kartopu örnekleme ile 18 yaş üzeri 600 kişiye ulaşılmış, 592 anket araştırmaya dahil edilmiştir. Medya kullanım alışkanlıkları bağlamında katılımcılar medyayı sırasıyla gündemi takip etmek ve içerik (yorum, görsel, video) paylaşmak amacıyla kullanmaktadır. COVID-19 konusunda bilgi elde etmek için TV ve İnternet haber ve sağlık siteleri, referans grubu olarak da doktorlar ve diğer sağlık çalışanlarının daha güvenilir bulunduğu belirlenmiştir. Aşı olma kararlarını en çok etkileyen grup ise doktorlardır.
Covid-19 Prevention: Level and Determinants of Knowledge, Attitude and Practice toward WHO Recommended Covid-19 Prevention Measures After Second Wave of Covid 19 Among Harar Population, Eastern Ethiopia: A Community-Based Cross-Sectional Study
Authors: Alemayehu Astawus , Demissie Abebaw , Yusuf Mohammed , Feleke Dereje , Minsamo Kirubel , Abdullahi Yasin , Lencha Abebe Gemechu , Tola Assefa
Published: November 2021

Result

In
this study, 75.1%, 44.7%, and 52.8% of participants had a good knowledge,
positive attitude and good practice toward COVID-19 prevention, respectively. Occupation
and educational status were found to have significant strong association with
level of knowledge. Occupation, educational status, monthly income and family
size were found to have significant strong association with level of attitude.
Marital status, educational status and family size were found to have
significant strong association with level of practice toward Covid-19 recommended
prevention measures.

Conclusion

Overall,
there is high level of knowledge and medium level of attitude and practice
toward Covid-19 recommended prevention measures. Repeated tailored information
using different media should be provided to the community regarding Covid-19
prevention methods. Existing Covid-19 prevention efforts should be strengthened
and evaluated to improve community preventive practices.
Too Much Knowledge, Not Enough Wisdom
Authors: Stonestreet John
Published: November 2021

No abstract necessary.
Demokrasi Indonesia
Authors: Mustofa Wahyu Amir
Published: November 2021

Demokrasi Indonesia merupakan suatu hak kebebasan warga negara untuk menyampaikan pesan,aspirasi sesuai peraturan, norma yang ada.
ARTIKEL TENTANG PERSATUAN DAN KESATUAN
Authors: Oktavianus Antonius
Published: November 2021

Catatan Artikel tentang persatuan dan kesatuan
Hak Warga Negara Indonesia atas Kesehatan di Era Pandemi COVI
Authors: Qadariah Musdalifah
Published: November 2021

HAM adalah hak yang melekat pada manusia karena kelahirannya sebagai manusia. Hak atas kesehatan meliputi hak untuk mendapatkan kehidupan dan pekerjaan yang sehat, hak untuk mendapatkan pelayanan kesehatan, dan perhatian khusus terhadap kesehatan ibu dan anak. Saat ini Coronavirus Disease 2019 atau yang sering biasa disebut Covid-19 merupakan sebuah pandemi yang tak pelak usai hingga saat ini wabah ini sudah mengakibatkan sejumlah perbuahan besar dalam berbagai sektor salah diantaranya yaitu sektor ekonomi. Kasus kematian Covid-19 kian hari kian meningkat. Upaya pemenuhan hak atas kesehatan dapat dilakukan dengan berbagai macam cara yang meliputi pencegahan dan penyembuhan. Indonesia menjadikan pelaksanaan vaksinasi COVID-19 sebagai bagian dari strategi penanggulangan pandemic. Dengan diperkuatnya imunitas masyarakat, produktivitas juga akan meningkat sehingga meminimalkan dampak ekonomi dan sosial yang selama ini menjadi salah satu isu utama pandemi COVID-19.Pelaksanaan vaksinasi COVID-19 tetap harus dibarengan dengan penerapan protokol kesehatan yang ketat, seperti menggunakan masker, mencuci tangan dan menjaga jarak aman minimal 1-2 meter. Hal ini tidak hanya berlaku di Indonesia saja, tapi di seluruh dunia pun mengalami dan harus melakukan hal yang s
Solidaritas Persatuan dan kesatuan
Authors: Soinbala Desem
Published: November 2021

Bangsa Indonesia adalah bangsa yang g bertuhan, berbudaya, agama, adat dan bahasa yang beragam. Mahasiswa beserta seluruh civitas akademik harus menjadi garda terdepan dalam menjaga dan mengawal ideologi serta menjaga persatuan bangsa. Peran kampus adalah mencetak para penerus bangsa, sehingga perannya begitu penting dalam kemajuan bangsa Indonesia. Mahasiswa sebagai bagian dari pemuda Indonesia merupakan aset berharga dari suatu bangsa. Penanaman sikap moral sangat penting bagi setiap mahasiswa untuk mencapai suatu hal yang diharapkan, melakukan yang terbaik terhadap pendidikan di Indonesia, menjaga keutuhan dan persatuan bangsa dengan menjaga interaksi antar mahasiswa satu sama lain. Itu semua merupakan bentuk dari peran aktif mahasiswa menjaga kesatuan NKRI.
Hippocampal Contribution to Probabilistic Feedback Learning: Modeling Observation- and Reinforcement-based Processes
Authors: Patt Virginie , Palombo Daniela , Esterman Michael , Verfaellie Mieke
Published: November 2021

Simple probabilistic reinforcement learning is recognized as a striatum-based learning system, but in recent years, has also been associated with hippocampal involvement. The present study examined whether such involvement may be attributed to observation-based learning processes, running in parallel to striatum-based reinforcement learning. A computational model of observation-based learning (OL), mirroring classic models of reinforcement-based learning (RL), was constructed and applied to the neuroimaging dataset of Palombo, Hayes, Reid, & Verfaellie (2019). Hippocampal contributions to value-based learning: Converging evidence from fMRI and amnesia. Cognitive, Affective & Behavioral Neuroscience, 19(3), 523–536. Results suggested that observation-based learning processes may indeed take place concomitantly to reinforcement learning and involve activation of the hippocampus and central orbitofrontal cortex (cOFC). However, rather than independent mechanisms running in parallel, the brain correlates of the OL and RL prediction errors indicated collaboration between systems, with direct implication of the hippocampus in computations of the discrepancy between the expected and actual reinforcing values of actions. These findings are consistent with previous accounts of a role for the hippocampus in encoding the strength of observed stimulus-outcome associations, with updating of such associations through striatal reinforcement-based computations. Additionally, enhanced negative RL prediction error signaling was found in the anterior insula with greater use of OL over RL processes. This result may suggest an additional mode of collaboration between the OL and RL systems, implicating the error monitoring network.
A Field Experiment on Business Opposition to the U.S.-China Trade War
Authors: Dolan Lindsay , Kubinec Robert , Nielson Daniel , Zhang Jack
Published: November 2021

Despite the harmful consequences of the U.S-China trade war, only a handful of firms took collective action to oppose it. To understand why, we implemented a field experiment in which we randomly provided detailed estimates of the costs of the trade war to U.S. company managers and measured their willingness to take actions either opposing or supporting the trade war. While overall our treatment counter-intuitively reduced opposition to the trade war, these effects were highly conditional on respondents' prior beliefs and the number of tariffs in their industry. The treatment increased opposition the most among subjects in industries with substantial tariffs who also thought the trade war was harmful. However, it decreased opposition among subjects who held neutral beliefs about the trade war. Finally, we find that a company’s political culture strongly predicts their political activity, suggesting political ideology and not just a company’s business interests shape corporate behavior.
Who Supports Expanding Surveillance? Exploring Public Opinion of Chinese Social Credit Systems
Authors: Liu Chuncheng
Published: November 2021

Pervasive surveillance in modern society has raised mounting debates, which are largely concentrated on the ethical dimension and lack sociological examination. Drawing on innovative national survey data, this study analyzes public opinion about social credit systems (SCSs), an emerging infrastructure that expands the depth and breadth of surveillance in China. I find a general high support for expanding surveillance and punishment yet key variations among different social groups. Counterintuitively, people with higher political capital do not wholly embrace the expanding surveillance and punishment. For example, Chinese Communist Party members are less likely to support state-centered SCSs compared to the general public. Higher political trust in the regime and socioeconomic status is consistently correlated with higher support, while different media consumption showed limited correlations. This study proposes an alternative theorization of surveillance and enriches our understanding of the heterogeneity and dynamic of the state and public in the authoritarian regime.
Examining the relationships between social identities of British Asian transgender /gender non-conforming and well-being.
Authors: JI Yuan , Bouguettaya Ayoub , Evans Elliot
Published: November 2021

AbstractObjective: The present study aimed to explore the roles of social identity (British Asian / TGNC)against mental health problems (depression) and well-being.Methods: This study is a mixed methods pilot study. British Asian TGNC adults were our targeted subjects. An online anonymous survey was opened for four weeks and shared by some LGBTQ+ communities in the U.K. We recruited three participants, which did not meet planned sample size requirements.Results: Due to the lack of participants, we cannot reject our support any of our hypothesis. Based on the qualitative analysis, we inferred some possible findings: (1) double stigmatized individuals reported great experiences of discrimination related to their stigmatized social identity; (2) people who hold double stigmatized identity may show asymmetric identification; (3) affirmation of multiple identities could provide resilience and then foster mental health and well-beings.Conclusion: Our study demonstrated the difficulties in recruitment double minority group of people. The reasons of the failure in recruitment could be (1) double stigmatized identity may lead to concealment (2) COVID-19 causes problems in direct contact. Implications on recruitment issues within double stigmatized identities are extensively discussed, with discussions against how these areas relate to effective contact and engagement with specialist service for British Asian TGNC individuals and communities. Having a theoretical and practical understanding of these issues may address future recruitment difficulties
Oddziaływanie społeczne przedsiębiorstw społecznych w teorii i praktyce
Authors: Grabowska Izabela
Published: November 2021

The publication is devoted to issues related to the development of tools for measuring social impact generated by social enterprises. A valuable aspect of the monograph is the inclusion of case studies of selected tools (such as social return on investment, local multiplier, balanced scorecard) in partnership with social enterprises. The authors pay special attention to solutions enabling the operationalization of social change measurement, taking into account not only financial but, above all, non-financial aspects. They believe that the measurement of impact should take into account not only the economic perspective, but also the public and social one, where values other than material profit also count. The tools should indicate the responsibility of entities towards various types of stakeholders and serve to increase the quality of social services by providing valuable information to individual organizations.
ENHANCING VALUE ENGINEERING APPLICATION IN THE SRI LANKAN BUILDING CONSTRUCTION INDUSTRY: A FRAMEWORK
Authors:   Department of Building Economics, University of Moratuwa, Sandupama A.V.P.U. , Ramachandra T. ,   Department of Building Economics, University of Moratuwa, Madushika U.G.D. ,   Department of Building Economics, University of Moratuwa
Published: November 2021

The concept of value engineering (VE) is used to optimise the cost, time, quality, and functional performance toward achieving the best value for client money. However, the application of VE in construction industries is limited as there are differences in the use of the VE concept to developing economies, application of cost-oriented procurement systems, and lack of a practically applicable framework. In the local construction context, VE is practiced in an ad hoc manner. Therefore, the current study aimed to develop a framework including a tailored approach to enhance the VE application in the building construction industry. A qualitative approach was adapted to solicit views of twenty-two (22) construction professionals who involved in the six (6) high-rise building construction projects and practiced the VE concept. Views of professionals were synthesised using content analysis and finally developed a framework including a tailored VE approach. The findings conclude that cost and time as the main value criteria which motivate the VE application. Further, VE application in the construction industry is initiated mostly in the construction stages while professionals’ preference is laid on the initial project phases. Consequently, the contractor change proposal was identified as the sound approach to deliver VE since motivations emerge during physical construction. Finally, a tailored VE approach was developed considering concept design, developed design, and construction stages with related VE motivations to enhance the VE application in the Sri Lankan building construction context in a simplified manner.
LIFE CYCLE COSTING IN CONSTRUCTION: CURRENT TRENDS AND EMERGING DIRECTIONS
Authors:   School of Civil Engineering and Built Environment, Liverpool John Moores University, UK, Manewa Anupa , Siriwardena Mohan , Wijekoon Christaline ,   School of Civil Engineering and Built Environment, Liverpool John Moores University, UK,   School of Civil Engineering and Built Environment, Liverpool John Moores University, UK
Published: November 2021

The current construction climate in the UK is moving forward with a much greater attention on cost certainty, sustainability and adoption of innovative technologies. The UK Construction Strategy 2025 provides a clear direction towards achieving such goals by 2025. Life Cycle Costing (LCC) is one of successful techniques for identifying the total cost of ownership in construction assets. Even though the technique has 50 years of history, the application and the diffusion of the technique within the construction domain is comparatively limited. Therefore, this study aims to investigate the evolution and current status of LCC within construction context through Bibliometric Analysis of journal publications indexed in Web of Science database (1970-2020). A series of Contents Analyses was performed and visualisation maps were generated via VOSviewer. The findings proved that LCC has been absorbed into construction in late 90’s and there is a continuous rise in the global uptake from 2013 onwards. With limited budgets and growing demand for sustainability, an integrated methodology linking LCC, Life Cycle Assessment and Performance optimisation is apparently the way forward for LCC.
USE OF AUGMENTED REALITY FOR EFFICIENT BUILDING MAINTENANCE IN SRI LANKA
Authors:   Department of Building Economics, University of Moratuwa, Rajapaksha M.R.N. , Sridarran P. ,   Department of Building Economics, University of Moratuwa, Rathnayake R.M.D.I.M. ,   Department of Building Economics, University of Moratuwa
Published: November 2021

With the advent of technological advancements in the field of building maintenance, attempts have been taken to address the issues confronted by building maintenance technicians in the global context. Augmented Reality (AR) is one such concept which combines real environment with virtual content in 3D space that is experimented and proven to be effective in making the building maintenance activities more efficient by eliminating the causes for such difficulties faced by the technicians. In Sri Lanka, there is very limited use of such technologies in building maintenance practices and it is reasonable to mention that use of AR is minimum in this field. A gap is identified as there is no considerable literature exploring applications of Augmented Reality to ease building maintenance activities in Sri Lanka. Therefore, an effort is made to investigate into this area through a qualitative approach by taking a case into study and conducting interviews among technicians followed by an expert interview. The research highlights the use of AR in making the building maintenance practices in terms of data and instruction visualization leading to more efficient and effective outcomes while discussing on the benefits such as making maintenance tasks efficient, cost and time savings and high customer satisfaction as well as possible barriers for implementation of a similar program such as developing a Building Information Model to an existing building, inconvenience in making technicians adopted into a new system in the context of Sri Lanka
Analisis Profitabilitas dengan Penyaluran Kredit Sebagai Variabel Intervening pada Perusahaan Perbankan di Bursa Efek Indonesia
Authors: jdep Titian Rendra Hadianto , jdep Tri Kartika Pertiwi
Published: November 2021

This research aims to determine the profitability of banks which is influenced by several factors. While this research uses purposive sampling with the analysis technique of Statistical Package for the Social Sciens and Path Analysis. The results of this study conclude: Capital Adequacy Ratio has a negative contribution to the level of bank profitability. The ratio of third party funds has a contribution to the level of bank profitability. Capital Adequacy Ratio has a negative contribution to Banking Credit Distribution (LDR, Third Party Funds Ratio (TPF) has a contribution to Banking Credit Distribution. Capital Adequacy Ratio has a contribution to the level of Banking Profitability by Lending as Intervening. Third Party Funds Ratio has a contribution to the level of Banking Profitability by Lending as Intervening Credit has a negative contribution to the level of bank profitability.
The role of patient preferences in adherence to treatment in chronic disease: a narrative review
Authors: Losi Serena , Berra Cesare Celeste Federico , Fornengo Riccardo , Pitocco Dario , Biricolti Giovanni , Orsini Federici Marco
Published: November 2021

Adherence to prescribed medication is important to the management of all diseases, especially those of chronic nature. Drug effectiveness is substantially compromised by therapy nonadherence. We reviewed the available evidences on the impact of patient preferences for therapy on adherence to a prescribed treatment in chronic diseases requiring long-term treatment. A search on PubMed retrieved 699 publications, leading to a selection of 12 publications: 6 on osteoporosis, 2 on moderate-to-severe asthma, 1 on type 1 diabetes, 1 on type 2 diabetes, 1 on kidney transplantation, and 1 on atrial fibrillation. Overall, 8 studies found a positive association between patient preference and adherence to therapy, while the others found no association. In general, overall adherence was considered to be high in the published studies. The reasons for a positive association included reduced dosing frequency, route of administration, lower costs, and favorable safety profile, which is related to the diverse nature of the pathology and its type and duration of treatment. A literature review suggests that achieving good adherence and persistence to therapy requires evaluation of patient preferences. In a period of increasingly limited resources, more effort is warranted to promote better adherence to therapy, especially when patients must self-manage their disease in the long term. Our results further highlight that insufficient attention has been given to the relationship between patient preference and adherence and point out the complex nature of adherence and the need for adequate patient education. More efforts are also needed to better understand the entity of cost savings for payers for specific treatments and the link with patient preference.
OPTIMIZATION OF THE CURVILINEAR BOREHOLE TRAJECTORIES BY THE METHODS OF LINEAR AND NONLINEAR PROGRAMMING
Authors:   National Transport University, Kyiv, Ukraine, E Andrusenko
Published: November 2021

Andrusenko E.N. Minimization of the cost of oil and gas borehole by the methods of linear and nonlinear programming. Visnyk National Transport University. Series «Economical sciences». Scientific and Technical Collection. - Kyiv: National Transport University, 2020. - Issue 2 (47). The task is posed of constructing optimal trajectories of oil and gas wells by linear and nonlinear programming methods, as well as the theory of optimal control. The object of study is the geometry of the axial line of deep directional, horizontal and branching trajectories of oil and gas wells. The purpose of the work is to build the optimal trajectory of an oil or gas well, ensuring its minimum cost, minimum length and minimum values of its construction parameters. A technique was developed for optimizing the geometry of the trajectory of an oil or gas well using the methods of optimal control theory. Cases of the formulation of the Lagrange, Mayer, and Boltz problems are considered under various (linear and nonlinear) constraints on the values of phase variables and control functions.
THE DEVELOPMENT OF DIGITAL PLATFORMS AND PRIORITIES OF THE ECONOMIC POLICY
Authors:   National Transport University, Kyiv, Ukraine, A Bazyliuk
Published: November 2021

The article explores the activities of digital platforms in the modern era of digital transformation. The proliferation of the platform type of economic relations is an objective process related to the digital and technological transformations in the modern world. This form provides the best competitive advantage for the platform customers as a result of receiving a "network" effect, which increases the value of the platform as its quantitative indicators increase. Platforms have been identified to generate both positive effects and increased risks associated with anticompetitive behavior due to the emergence of new forces with powerful market power. In addition, platforms can contribute to erosion of the tax base, increasing all kinds of discrimination and inequality. In Ukraine, as an open economy, the proliferation of new forms of economic relations organization creates a significant potential for productivity gains due to the wide potential for reducing transaction costs for economic relations entities and increasing their competitiveness both domestically and internationally. The article proposes to support the reorganization of socio-economic relations related to the proliferation of platforms on the basis of changes in antitrust, labor and tax law.
CHOICE OF METHODS OF ORGANIZATION OF INTERNATIONAL CARRIAGE OF CONSIGNMENTS IN LOGISTICAL CHAINS
Authors:   National Transport University, Kyiv, Ukraine, D Svirin
Published: November 2021

The article deals with the methods of delivery of ICCLC, such as: through, terminal, prefabricated and more. The influence of factors on the choice of a method of delivery of ICCLC. The object of study is the process of international road transportation of goods. The purpose of the work is to develop the main stages of the methodology of choosing the methods of the organization of ICCLC, depending on the conditions of transportation and customer requirements. To increase the efficiency of the ICCLC, one of the important tasks that carriers and freight forwarders solve is the choice of methods for organizing the ICCLC in logistics chains. It is advisable to use effective delivery methods in certain conditions of transportation, such as through, terminal, prefabricated, terminal (traction shoulders) and others. When choosing these methods, many factors are taken into account, such as the partisanship of international road transportation of goods, the geographical location of shippers and consignees, the state of highways and more. When organizing ICCLC using the above methods, different combinations are possible related to the particularities of transportation in the countries of departure and destination and the requirements of the cargo owners. The choice of the method of ICCLC organization is influenced by the criteria of ICCLC efficiency (for example, the time of delivery of goods, the cost of 1 km run of vehicle, the cost of 1 tkm of transport work, etc.). In addition to the above criteria, which help to determine the effectiveness of a particular method of delivery of goods, the rationality of the method in each individual situation depends on the possibility of the arrival of vehicle for unloading at the appointed time. This is because of the arrival time of the vehicle must be linked to other operations occurring at the terminal. The main stages of the methodology for selecting the organization of ICCLC are developed, taking into account the above factors and the impact of criteria on them. KEYWORDS: PARTITIONALITY, METHODS OF ORGANIZATION OF INTERNATIONAL CARGO TRANSPORTATION.
Tissue Engineering in Stomatology: A Review of Potential Approaches for Oral Disease Treatments
Authors: Cao Lilan , Su Huiying , Si Mengying , Xu Jing , Chang Xin , Lv Jiajia , Zhai Yuankun
Published: November 2021

Tissue engineering is an emerging discipline that combines engineering and life sciences. It can construct functional biological structuresin vivoorin vitroto replace native tissues or organs and minimize serious shortages of donor organs during tissue and organ reconstruction or transplantation. Organ transplantation has achieved success by using the tissue-engineered heart, liver, kidney, and other artificial organs, and the emergence of tissue-engineered bone also provides a new approach for the healing of human bone defects. In recent years, tissue engineering technology has gradually become an important technical method for dentistry research, and its application in stomatology-related research has also obtained impressive achievements. The purpose of this review is to summarize the research advances of tissue engineering and its application in stomatology. These aspects include tooth, periodontal, dental implant, cleft palate, oral and maxillofacial skin or mucosa, and oral and maxillofacial bone tissue engineering. In addition, this article also summarizes the commonly used cells, scaffolds, and growth factors in stomatology and discusses the limitations of tissue engineering in stomatology from the perspective of cells, scaffolds, and clinical applications.
Design of Porous Metal Block Augmentation to Treat Tibial Bone Defects in Total Knee Arthroplasty Based on Topology Optimization
Authors: Liu Yang , Chen Bingpeng , Wang Chenyu , Chen Hao , Zhang Aobo , Yin Weihuang , Wu Naichao , Han Qing , Wang Jincheng
Published: November 2021

Metal block augmentation, which is used for the treatment of tibial bone defects in total knee arthroplasty, with high stiffness will cause significant alteration in stress distribution, and its solid structure is not suitable for osseointegration. This study aimed to design a porous block to reduce weight, promote bone ingrowth, and improve its biomechanical performance. The metal block augmentation technique was applied to finite element models of tibial bone defects. Minimum compliance topology optimization subject to volume fraction combined with the porous architecture was adopted to redesign the block. Biomechanical changes compared with the original block were analyzed by finite element analysis. The stress distribution of the block and proximal tibia was recorded. The strain energy density of the proximal tibia was obtained. The newly designed block realized 40% weight reduction. The maximum stress in the optimized block decreased by 11.6% when compared with the solid one. The maximum stress of the proximal tibia in the optimized group increased by 18.6%. The stress of the anterior, medial, and posterior parts of the proximal medial tibia in the optimized group was significantly greater than that in the original group (all p < 0.05). The optimized block could effectively improve the biomechanical performance between the block and the bone. The presented method might provide a reference for the design of customized three-dimensional printed prostheses.
Tumor Cell Distinguishable Nanomedicine Integrating Chemotherapeutic Sensitization and Protection
Authors: Liu Sen , Shen Can , Qian Cheng , Wang Jianquan , Yang Zhongmei , Wei Yanchun , Quan Li , Pan Changjiang , Hu Yong , Ye Wei
Published: November 2021

Theoretically, with a high enough drug dosage, cancer cells could be eliminated. However, the dosages that can be administered are limited by the therapeutic efficacy and side effects of the given drug. Herein, a nanomedicine integrating chemotherapeutic sensitization and protection was developed to relieve the limitation of administration dosage and to improve the efficacy of chemotherapy. The nanomedicine was endowed with the function of synergistically controlled release of CO and drugs under near-infrared (NIR) light irradiation. CO photo-induced release system (COPIRS) was synthesized by constructing an electron excitation–electron transfer group–electron-induced CO release structure and was used as the hydrophobic part, and then hydrophilic polymer (polyethylene glycol; PEG) was introduced by a thermal-responsive groups (DA group), forming a near-infrared-induced burst-release nanocarrier. In vitro and in vivo experiments showed that the nanomedicine can distinguish between tumor and normal cells and regulates the resistance of these different cells through the controlled release of carbonic oxide (CO), simultaneously enhancing the efficacy of chemotherapy drugs on tumor cells and chemotherapeutic protection on normal cells. This strategy could solve the current limitations on dosages due to toxicity and provide a solution for tumor cure by chemotherapy.
Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis
Authors: Lai Suxian , Chen Lijun , Zhan Pingyun , Lin Guofu , Lin Hai , Huang Huibin , Chen Qingshi
Published: November 2021

Circular RNAs (circRNAs) participate in the development of various kinds of diseases. However, the function and roles of circRNAs in obstructive sleep apnea (OSA)-induced cardiovascular disease remain poorly understood. Therefore, we sought to explore the circRNA expression profiles and predict their functions in OSA-induced cardiac injury with the use of bioinformatics analysis. The model of OSA was established in mouse treated by chronic intermittent hypoxia (CIH) exposure. Then, we screened the circRNA profile using circRNA microarray. By comparing circRNA expression in three matched pairs of CIH-treated cardiac tissues and controls, differentially expressed circRNAs were identified in the CIH groups. Comparison of the selected circRNAs expression levels was performed between qRT-PCR and microarray. Meanwhile, we employed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses to predict the functions of these selected circRNAs. Finally, we constructed a circRNA-miRNA-mRNA network based on the target prediction. It was found that a total of 124 circRNAs were differentially expressed in CIH-treated cardiac tissues (p ≤ 0.05, fold-change ≥ 1.5). Among them, 23 circRNAs were significantly down-regulated, and the other 101 were up-regulated. Then, ten circRNAs were randomly selected to validate the reliability of the microarray results by using qRT-PCR. Next, we conducted the GO and KEGG pathway analysis to explore the parental genes functions of differentially expressed circRNA. Finally, two significantly differentially expressed circRNAs (mmu_circRNA_014309 and mmu_circRNA_21856) were further selected to create a circRNA-miRNA-mRNA regulation network. Our study did first reveal that the differentially expressed circRNAs played a vital role in the pathogenesis of OSA-induced cardiac damage. Thus, our findings bring us closer to unraveling the pathophysiologic mechanisms and eliciting novel therapeutic targets for the treatment of OSA-associated cardiovascular diseases.
The Novel LncRNA AK035396 Drives Cardiomyocyte Apoptosis Through Mterf1 in Myocardial Ischemia/Reperfusion Injury
Authors: Xu Zhaoyan , Mo Yuanxi , Li Xinyi , Hong Wanzi , Shao Sisi , Liu Yaoxin , Shu Fen , Jiang Lei , Tan Ning
Published: November 2021

Background: Myocardial ischaemia/reperfusion (I/R) injury is still a major challenge in clinical treatment. The role of long non-coding RNA (lncRNA) in the regulation of myocardial I/R injury still needs to be elucidated.

Methods: The primary isolated neonatal mousse cardiomyocytes and adult mice were used to construct a myocardial ischemia-reperfusion model. qRT-PCR is used to verify gene expression in myocardial tissue and myocardial cells. The effect of AK035396 in primary cardiomyocytes and mouse myocardium was confirmed by TUNEL staining and in vitro flow cytometry experiments. RNA pulldown and Western blot were used to identify AK035396 interacting proteins. The expression of apoptosis-related proteins was identified by qRT-PCR and Western blot.

Results:In vivo and in vitro MIRI models, AK035396 was up-regulated after myocardial infarction. Functional studies have shown that knockdown of AK035396 reduces the apoptosis of primary cardiomyocytes and mouse myocardial tissue. AK035396 directly interacts with Mterf1 and inhibits the level of Mterf1. Further experiments have shown that inhibiting Mterf1 will promote the expression of mitochondrial genes COXII and CYTb and cause cell apoptosis.

Conclusion: AK035396 plays an important role in myocardial ischaemia-reperfusion injury by regulating the Mterf1-COXII/CYTb pathway.
Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan–Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen
Authors: Li Chen , Wang Ke , Xie Dong
Published: November 2021

Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer–drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan–ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan–ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan–ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer–drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.
Exploring the Correlation and Protective Role of Diabetes Mellitus in Aortic Aneurysm Disease
Authors: Arun Divyatha , Munir Wahaj , Schmitt Lara Victoria , Vyas Rohan , Ravindran Jeuela Iris , Bashir Mohamad , Williams Ian Michael , Velayudhan Bashi , Idhrees Mohammed
Published: November 2021

Introduction: Diabetes mellitus is recognised as a significant risk factor for cardiovascular and peripheral vascular disease, as the abnormal metabolic state increases the risk for atherosclerosis, occlusive arterial disease and vascular dysfunction. There have been reports of potential association across the literature that illustrates a link between diabetes mellitus and aortic aneurysm, with the former having a protective role on the development of the latter.

Methods: A thorough literature search was performed through electronic databases, to provide a comprehensive review of the study's reporting on the association of diabetes mellitus and aortic aneurysm, discussing the mechanisms that have been reported; furthemore, we reviewed the reports of the impact of oral hypoglycameic agents on aortic aneurysms.

Results: Various proposed mechanisms are involved in this protective process including endothelial dysfunction, chronic hyperglycemia and insulin resistance. The evidence suggests a negative association between these disease process, with prevelance of diabetes mellitus resulting in lower rates of aortic aneurysm, via its protective mechanistic action. The increase in advanced glycation end products, increased arterial stiffness and vascular remodelling seen in diabetes, was found to have a profound impact on aneurysm development, its slow progression and lower rupture rate in these individuals. This review has also highlighted the role of oral hypoglycaemic agents having a protective effect against AA disease.

Conclusion: A decrease in development, progression and mortality from aortic aneurysms as well as reduced rates of dissection, have been observed in those with diabetes. This review has provided a comprehensive insight on the effect of diabetes and its physiological processes, and elements of its con-committant treatment, having a protective role against these aortic diseases.
Strengthening Individual Teacher-Child Relationships: An Intervention Study Among Student Teachers in Special Education
Authors: Koenen Anne-Katrien , Borremans Liedewij Frieke Nel , De Vroey Annet , Kelchtermans Geert , Spilt Jantine Liedewij
Published: November 2021

Relationships with children with special educational needs can be emotionally challenging for teachers and conflicts may negatively impact both children and teachers. Beginning teachers in particular may struggle with negative teacher-child relationships and the emotions these invoke. A first step in coping with relationship difficulties with specific children is increasing the teacher’s awareness and understanding of relational themes and emotions in the relationship with that specific child. Therefore, this multiple case intervention study examined the effects of LLInC (Leerkracht Leerling Interactie Coaching in Dutch, or: Teacher Student Interaction Coaching) in a sample of six student teachers in their final internship. LLInC is a relationship-focused coaching program using narrative interview techniques to facilitate in-depth reflection on teacher-child relationships. The intervention aims to foster teachers’ awareness of (negative) internalized emotions and beliefs in order to improve closeness and positive affect, and to reduce conflict and negative affect in teacher-child relationships. Participants repeatedly reported on their perceptions of the teacher-child relationship and on emotions in relation to a specific child before and after the LLInC intervention, which consisted of two one-on-one sessions with a coach. Visual between- and within-phases analyses revealed differential intervention effects across teachers on the development of teacher-child relationship quality and relationship emotions. For all teachers, except for one, positive effects were found on feelings of joy and perceptions of closeness. Preventive effects (i.e., stopping downward trends) were more often observed for competence-based and relationship-based emotions and perceptions (competence, commitment, closeness) than for basic emotions (joy, anger, worry). Although further research is needed, the results highlight the potential of LLInC in influencing pre-service teachers’ child-specific emotions and relationship perceptions. Directions for future research and implications for teacher education are discussed.
Stress-Hormone Dynamics and Working Memory in Healthy Women Who Use Oral Contraceptives Versus Non-Users
Authors: Høgsted Emma Sofie , Borgsted Camilla , Dam Vibeke H. , Nasser Arafat , Rye Jørgensen Niklas , Ozenne Brice , Stenbæk Dea Siggaard , Frokjaer Vibe G.
Published: November 2021

Background

Women who use oral contraceptives (OCs) may have a higher risk of developing a depression, which is associated with both vulnerability to stress and cognitive dysfunction. OCs disrupt the hypothalamic-pituitary-gonadal (HPG) axis by suppressing endogenous sex steroid production including estradiol. The HPG axis and the hypothalamic-pituitary-adrenal (HPA) axis are known to interact, possibly through modulations driven by estradiol. OCs may affect HPA regulation capacity, i.e., disturb cortisol dynamics such as the cortisol awakening response (CAR), and influence cognition such as working memory (WM). We hypothesize that OC use is associated with blunted cortisol dynamics and impaired WM performance relative to non-users.

Methods

Data from 78 healthy women in the reproductive age were available from the CIMBI database. We evaluated if CAR and WM differed between OC users (n=25) and non-users (n=53) and if the level of estradiol modulated the OC use effect on CAR or WM in generalized least square models.

Results

We found that OC users had a blunted CAR (p= 0.006) corresponding to a 61% reduction relative to non-users; however, no estradiol-BY-OC use interaction effect was observed on CAR. Also, OC users had higher cortisol levels at awakening compared to non-users (p = 0.03). We observed no effect of OC use or an estradiol-BY-OC use interaction effect on WM. Also, within the OC user group, neither CAR nor WM was associated with suppressed estradiol. CAR was not associated with WM.

Conclusion

Healthy women who use OCs have blunted cortisol dynamics relative to non-users. However, we could not detect OC use effects on working memory in our sample size. We speculate that disrupted cortisol dynamics may be important for the emergence of depressive symptoms in OC users.
Suppression of a Novel Vitellogenesis-Inhibiting Hormone Significantly Increases Ovarian Vitellogenesis in the Black Tiger Shrimp, Penaeus monodon
Authors: Laphyai Phaivit , Kruangkum Thanapong , Chotwiwatthanakun Charoonroj , Semchuchot Wanita , Thaijongrak Prawporn , Sobhon Prasert , Tsai Pei-San , Vanichviriyakit Rapeepun
Published: November 2021

In this study, a novel Crustacean Hyperglycemic Hormone-type II gene (CHH-type II) was identified and biologically characterized in a shrimp, Penaeus monodon. Based on its structure and function, this gene was named P. monodon vitellogenesis-inhibiting hormone (PemVIH). The complete cDNA sequence of PemVIH consisted of 1,022 nt with an open reading frame (ORF) of 339 nt encoding a polypeptide of 112 amino acids. It was classified as a member of the CHH-type II family based on conserved cysteine residues, a characteristically positioned glycine residue, and the absence of CHH precursor-related peptide (CPRP) domain. The deduced mature PemVIH shared the highest sequence similarities with giant river prawn sinus gland peptide A. Unlike P. monodon gonad-inhibiting hormone (PemGIH), PemVIH was expressed only in the brain and ventral nerve cord, but not the eyestalks. Whole mount immunofluorescence using a newly generated PemVIH antiserum detected positive signals in neuronal cluster 9/11 and 17 of the brain, commissural ganglion (CoG), and neuronal clusters of ventral nerve cord. The presence of PemVIH-positive neurons in CoG, a part of stomatogastric nervous system, suggested a potential mechanism for crosstalk between nutritional and reproductive signaling. The role of PemVIH in vitellogenesis was evaluated using RNA interference technique. Temporal knockdown of PemVIH in female subadults resulted in a 3-fold increase in ovarian vitellogenin expression, suggesting an inhibitory role of PemVIH in vitellogenesis. This study provided novel insight into the control of vitellogenesis and additional strategies for improving ovarian maturation in P. monodon without the current harmful practice of eyestalk ablation.