bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone Metastases of Diverse Primary Origin Frequently Express the VDR (Vitamin D Receptor) and CYP24A1
Authors: Seiler Jonas , Ebert Regina , Rudert Maximilian , Herrmann Marietta , Leich Ellen , Weißenberger Manuela , Horas Konstantin
Published: November 2022

Active vitamin D (1,25(OH)2D3) is known to exert direct anti-cancer actions on various malignant tissues through binding to the vitamin D receptor (VDR). These effects have been demonstrated in breast, prostate, renal and thyroid cancers, which all have a high propensity to metastasise to bone. In addition, there is evidence that vitamin D catabolism via 24-hydroxylase (CYP24A1) is altered in tumour cells, thus, reducing local active vitamin D levels in cancer cells. The aim of this study was to assess VDR and CYP24A1 expression in various types of bone metastases by using immunohistochemistry. Overall, a high total VDR protein expression was detected in 59% of cases (39/66). There was a non-significant trend of high-grade tumours towards the low nuclear VDR expression (p = 0.07). Notably, patients with further distant metastases had a reduced nuclear VDR expression (p = 0.03). Furthermore, a high CYP24A1 expression was detected in 59% (39/66) of bone metastases. There was a significant positive correlation between nuclear VDR and CYP24A1 expression (p = 0.001). Collectively, the VDR and CYP24A1 were widely expressed in a multitude of bone metastases, pointing to a potential role of vitamin D signalling in cancer progression. This is of high clinical relevance, as vitamin D deficiency is frequent in patients with bone metastases.
Ultrasound-Guided Dynamic Needle-Tip Positioning Method Is Superior to Conventional Palpation and Ultrasound Method in Arterial Catheterization
Authors: Wu Guannan , Chen Chen , Gu Xiaoling , Yao Yanwen , Yuan Dongmei , Lv Jiawen , Zhao Beilei , Wang Qin
Published: November 2022

Background: Dynamic needle-tip positioning (DNTP) was shown to improve arterial cannulation efficiency with fewer complications than conventional palpation and ultrasound methods by some studies. However, this is still controversial, and we performed this meta-analysis to comprehensively assess its value in arterial cannulation. Methods: A literature search of randomized controlled trials was conducted, and 11 studies were finally included. Efficiency outcomes (first-attempt success, overall success, and total cannulation time) and complications (hematoma, thrombosis, posterior wall puncture, and vasospasm) were separately analyzed. Subgroup analyses in different populations under cannulation were also performed. Results: DNTP was associated with increased first-attempt success (pooled RR = 1.792, p < 0.001), overall success (pooled RR = 1.368, p = 0.001), and decreased cannulation time (pooled SMD = −1.758, p = 0.001) than palpation. DNTP gained even more advantage in small children and infants. No significant difference in these outcomes between DNTP and conventional ultrasound method was detected. Fewer hematoma occurred in DNTP than palpation (pooled RR = 0.265, p < 0.001) or traditional ultrasound (pooled RR = 0.348, p < 0.001). DNPT was also associated with fewer posterior wall punctures (pooled RR = 0.495, p = 0.001) and vasospasm (pooled RR = 0.267, p = 0.007) than traditional ultrasound. Conclusions: DNTP was a better choice in artery cannulation than conventional palpation and ultrasound method, especially in small children and infants.
The Challenge of High Coronary Thrombotic Events in Patients with ST-Segment Elevation Myocardial Infarction and COVID-19
Authors: Anghel Larisa , Tudurachi Bogdan-Sorin , Leonte Andreea , Sascău Radu Andy , Zota Ioana Mădălina , Bazyani Amin , Tinică Grigore , Stătescu Cristian
Published: November 2022

The aim of this observational study was to describe the characteristics and outcomes of coronavirus disease 2019 (COVID-19)-positive patients with ST-segment elevation myocardial infarction (STEMI), with a special focus on factors associated with a high risk of coronary thrombosis and in-hospital mortality. Comparing the two groups of patients with STEMI separated according to the presence of SARS-CoV-2 infections, it was observed that COVID-19 patients were more likely to present with dyspnea (82.43% vs. 61.41%, p = 0.048) and cardiogenic shock (10.52% vs. 5.40%, p = 0.012). A longer total ischemia time was observed in COVID-19 patients, and they were twice as likely to undergo coronary angiography more than 12 hours after the onset of symptoms (19.29% vs. 10.13%, p = 0.024). In 10 of 57 COVID-19-positive patients, a primary PCI was not necessary, and only thromboaspiration was performed (17.54% vs. 2.70%, p < 0.001). Platelet level was inversely correlated (r = −0.512, p = 0.025) with a higher risk of coronary thrombosis without an atherosclerotic lesion. Using a cut-off value of 740 ng/ml, D-dimers predicted a higher risk of coronary thrombosis, with a sensitivity of 80% and a specificity of 66% (ROC area under the curve: 0.826, 95% CI: 0.716–0.935, p = 0.001). These are novel findings that raise the question of whether more aggressive antithrombotic therapy is necessary for selected COVID-19 and STEMI patients.
The Association between Serum Albumin and Post-Operative Outcomes among Patients Undergoing Common Surgical Procedures: An Analysis of a Multi-Specialty Surgical Cohort from the National Surgical Quality Improvement Program (NSQIP)
Authors: Nipper Cole A. , Lim Kelvin , Riveros Carlos , Hsu Enshuo , Ranganathan Sanjana , Xu Jiaqiong , Brooks Michael , Esnaola Nestor , Klaassen Zachary , Jerath Angela , Arrington Amanda , Wallis Christopher J. D. , Satkunasivam Raj
Published: November 2022

While studies have demonstrated an association between preoperative hypoalbuminemia and adverse clinical outcomes, the optimal serum albumin threshold for risk-stratification in the broader surgical population remains poorly defined. We sought define the optimal threshold of preoperative serum albumin concentration for risk-stratification of adverse post-operative outcomes. Using the American College of Surgeons National Surgical Quality Improvement Program Database, we identified 842,672 patients that had undergone a common surgical procedure in one of eight surgical specialties. An optimal serum albumin concentration threshold for risk-stratification was determined using receiver-operating characteristic analysis. Multivariable logistic regression analysis was used to evaluate the odds of adverse surgical events; a priori defined subgroup analyses were performed. A serum albumin threshold of 3.4 g/dL optimally predicted adverse surgical outcomes in the broader cohort. After multivariable analysis, patients with hypoalbuminemia had increased odds of death within 30 days of surgery (odds ratio [OR] 2.01, 95% confidence interval [CI] 1.94–2.08). Hypoalbuminemia was associated with greater odds of primary adverse events among patients with disseminated cancer (OR 2.03, 95% CI 1.88–2.20) compared to patients without disseminated cancer (OR 1.47, 95% CI 1.44–1.51). The standard clinical threshold for hypoalbuminemia is the optimal threshold for preoperative risk assessment.
Effects of Adding Cinnamon, ZnO, and CuO Nanoparticles on the Antibacterial Properties of a Glass Ionomer Cement as the Luting Agent for Orthodontic Bands and Their Cytotoxicity
Authors: Shafaee Hooman , Khosropanah Haida , Rahimi Hamidreza , Darroudi Majid , Rangrazi Abdolrasoul
Published: November 2022

This study was conducted to evaluate the effects of adding cinnamon nanoparticles (NPs), Zinc oxide (ZnO) nanoparticles (NPs), and Copper oxide (CuO) NPs on the antibacterial property of a luting and lining glass ionomer cement (GIC) that was used for the cementation of orthodontic bands to the tooth. Cinnamon NPs, ZnO NPs, and CuO NPs were added into a luting and lining GIC in weight percentages of 1%, 2%, and 4%, respectively while a non-modified GIC was considered as the control group. Agar disc diffusion test was applied to assess the antimicrobial property of samples against Streptococcus mutans (S. mutans). The cytotoxicity of the nanoparticles was examined through the MTT assay for gingival fibroblasts. Data showed that GIC containing cinnamon and ZnO NPs displayed a larger inhibition zone diameter and greater antibacterial activity against S. mutans than CuO NPs. Meanwhile, there were no significant differences in the inhibition zone diameter of cinnamon NPs and ZnO NPs. The cytotoxicity assessment revealed the lower cytotoxicity of cinnamon NPs and the higher cytotoxicity of CuO NPs while the cytotoxicity of ZnO NPs was observed to be higher than cinnamon NPs and lower than CuO NPs. GIC containing cinnamon NPs exhibited noticeable antibacterial activity against S. mutans and cinnamon NPs revealed less cytotoxicity and it is can be labeled as a favorable option for further assessment to be applied in fixed orthodontic treatments for the cementation of bands to teeth.
Polyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis
Authors: Semak Vladislav , Eichhorn Tanja , Weiss René , Weber Viktoria
Published: November 2022

Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we developed blood-compatible matrices by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. Photoreactive zwitterionic terpolymers were synthesized by free-radical polymerization of zwitterionic, photoreactive, and fluorescent monomers. Upon UV irradiation, the terpolymers were photodeposited and mutually crosslinked on the surface of hydrophobic polystyrene-co-divinylbenzene and hydrophilic polyacrylamide-co-polyacrylate (DALI) beads. Fluorescent microscopy revealed coatings with an average thickness of 5 µm, which were limited to the bead surface. Blood compatibility was assessed based on polymer-induced hemolysis, coagulation parameters, and in vitro tests. The maintenance of the adsorption capacity after coating was studied in human whole blood with cytokines for polystyrene beads (remained capacity 25–67%) and with low-density lipoprotein (remained capacity 80%) for polyacrylate beads. Coating enhanced the blood compatibility of hydrophobic, but not of hydrophilic adsorbents. The most prominent effect was observed on coagulation parameters (e.g., PT, aPTT, TT, and protein C) and neutrophil count. Polycarboxybetaine with a charge spacer of five carbons was the most promising polyzwitterion for the coating of adsorbents for whole blood apheresis.
Pathways and Hot Spots of Floating and Submerged Microplastics in Atlantic Iberian Marine Waters: A Modelling Approach
Authors: Rosas Eloah , Martins Flávio , Tosic Marko , Janeiro João , Mendonça Fernando , Mills Lara
Published: November 2022

Plastic pollution has been observed in many marine environments surrounding the Iberian Peninsula, from the surface water to deeper waters, yet studies on their pathways and accumulation areas are still limited. In this study, a global ocean reanalysis model was combined with a particle-tracking Lagrangian model to provide insights into the pathways and accumulation patterns of microplastics originating in southern Portuguese coastal waters (SW Iberian). The study investigates microplastics floating on the surface as well as submerged at different water depths. Model results suggest that the North Atlantic Gyre is the main pathway for microplastics in surface and subsurface waters, transporting the microplastics southwards and eastwards towards the Mediterranean Sea and the Canary Islands. Currents flowing out of the Mediterranean Sea act as the main pathway for microplastics in deep waters, transporting the microplastics along western Iberia. An average residence time of twenty days in the coastal waters suggests that microplastics do not accumulate close to their sources due to their relatively fast transport to adjacent ocean areas. Notably, a significant proportion of microplastics leave the model domain at all depths, implying that SW Iberia may act as a source of microplastics for the adjacent areas, including the Mediterranean Sea, Morocco, the Canary Islands, Western Iberia, and the Bay of Biscay.
Numerical Study of Influences of Onshore Wind on Hydrodynamic Processes of Solitary Wave over Fringing Reef
Authors: Guo L. , Qu K. , Huang J. X. , Li X. H.
Published: November 2022

Many post-disaster surveys have reported on the natural function and effectiveness of fringing reef in preventing the shoreline from the inundation caused by severe weather events. Prior studies mainly focus on the wave propagating, transforming, and breaking on the fringing reefs by assuming that ocean waves propagate in an ideal environment where the wind is absent. However, in the real severe ocean environment, huge surges and waves always occur simultaneously with the strong winds. The wave profile can be easily reshaped by the strong winds, which can also significantly affect the way that ocean waves propagate on the fringing reefs. Therefore, it is necessary to study the hydrodynamics of fringing reefs under the combined action of wind and waves. To study the influences of the onshore wind on the hydrodynamics of solitary wave on the fringing reef, the finite volume method is applied to solve the governing equations of two-phase incompressible flow and a high-resolution numerical wind-wave tank is established in this study. Effects of several main factors are analyzed in detail. The research results show that the onshore wind can significantly increase the maximum wave runup height (maximum by 38.49%) and decrease the wave reflection coefficient of solitary wave (maximum by 8.66%). It is hoped that the research results of this study can enhance the understandings on the hydrodynamics of ocean waves on the fringing reefs during severe weather events.
A New Theoretical Dynamic Analysis of Ship Rolling Motion Considering Navigational Parameters, Loading Conditions and Sea State Conditions
Authors: Pérez-Canosa José M. , Orosa José A. , Galdo María Isabel Lamas , Barros Juan José Cartelle
Published: November 2022

Despite the IMO’s efforts and the large quantity of research carried out over the years concerning the sudden loss of stability in fishing vessels, and even the damage done to merchant fleets due to cargo shifting, accidents with very relevant consequences continue to occur. This paper can be considered as a continuation of the recent research of authors which was carried out with ships in static conditions, with pure beam seas and without resistance. The aim of the present research is to provide a reference for ships’ operators to improve the ship’s behavior and seakeeping, to alter the ship’s loading conditions or the navigational parameters (heading and speed), and even be aware of the time available to carry out these modifications before reaching dangerous situations. For this, all sea state conditions were mathematically modelled for, including the ship’s rolling motion both in static and in realistic and dynamic conditions, with the waves influencing the vessel by coming from any direction. Relevant results of easy comprehension for ships’ operators are shown in each of the models, which were validated with a representative real case study.
Why Do Bio-Carbonates Exist?
Authors: Pomar Luis , Hallock Pamela , Mateu-Vicens Guillem , Baceta Juan I.
Published: November 2022

Calcium carbonate precipitation associated with biotic activity is first recorded in Archaean rocks. The oldest putative fossils related to hydrothermal vents have been dated at ~3.77 Ga (possibly 4.29 Ga). Stromatolites, the oldest dated at 3.70 Ga, have since occurred through Earth history, despite dramatic changes in physical and chemical conditions in aquatic environments. A key question is: what advantages do photosynthesizing aquatic prokaryotes and algae gain by precipitating carbonates? We propose the Phosphate Extraction Mechanism (PEM) to explain the benefits of biomineralization in warm, oligotrophic, alkaline, euphotic environments. Carbonate precipitation enhances access to otherwise limited carbon dioxide and phosphate in such environments. This mechanism also provides an explanation for prolific production of carbonates during times of elevated atmospheric carbon dioxide at intervals in the Phanerozoic.
Hydrodynamic and Particle Drift Modeling as a Support System for Maritime Search and Rescue (SAR) Emergencies: Application to the C-212 Aircraft Accident on 2 September, 2011, in the Juan Fernández Archipelago, Chile
Authors: Córdova Pablo , Flores Raúl P.
Published: November 2022

Search and rescue (SAR) refers to every operation aiming to find someone presumed lost, sick, or injured in remote or hard-to-access areas. This study presents the design of an operational system that supports maritime SAR emergencies by combining information from global hydrodynamic models (GHM) and a local hydrodynamic model (LHM) implemented in FVCOM. The output of these hydrodynamic models is used as input in a multiple particle drift estimator (MPDE) to estimate the trajectories of the floating elements derived from accidents in the ocean. The MPDE also includes trajectory estimates using the empirical LEEWAY formulation. The modeling system is validated with data collected during a SAR emergency that occurred on 2 September 2011, where a C-212 aircraft from the Chilean Air Force destined to the Juan Fernández Archipelago crashed in the ocean between the islands of Santa Clara and Robinson Crusoe. Trajectories were assessed in terms of the commonly used NCLS (normalized cumulative Lagrangian separation) performance indicator and a modified version, NCLSmod, which considers both the movement and orientation of the trajectories. The LHM was executed in three scenarios: forced only with tide, forced with tide and wind combined, and forced only with wind. The performance of the different models varied in response to the ocean–atmosphere conditions and their local variations at the time of the accident. In times of calm wind, models with tidal influence performed better, while wind-forced models performed better when winds were greater than 7 km h−1. The use of FVCOM (LHM) solved the coastal circulation and accounted for bathymetric effects in the Juan Fernández Archipelago area. This resulted in an improved variability and distribution of the modeled trajectories compared to the observed drifter trajectories. This work is the first study related to cases of maritime SAR emergencies in Chile, and provides a fast tool to estimate search areas based on an ensemble of particle drift and trajectory forecasts using multiple publicly available data sources.
Collaborative Optimization of Yard Crane Deployment and Inbound Truck Arrivals with Vessel-Dependent Time Windows
Authors: Ma Mengzhi , Zhao Wenting , Fan Houming , Gong Yu
Published: November 2022

Due to mega-ships, increasing container throughput, and nonuniform truck arrivals, many container terminals face challenges of unbalanced workloads of yard equipment, shortage of equipment resources in peak hours, and congestion problem. To solve such issues, we propose a mixed-integer bilevel programming model to optimize the vessel-dependent time windows for inbound trucks and yard crane deployment simultaneously. In the proposed bilevel model, the upper level aims to minimize the total truck waiting time at the container terminal gate and yard, while the lower level is formulated to minimize the total workload overflow to next shift in the whole container yard. The optimal yard crane deployment obtained in the lower level will transfer to the upper level problem to determine the waiting time of trucks in the yard and then affect the truck arrivals pattern. To solve the model, a hybrid algorithm—called hybrid genetic algorithm, based on collective decision optimization—is put forward by combining the genetic algorithm and the collective decision optimization algorithm. Numerical experiments are conducted to validate the proposed approach is effective to simultaneously flatten truck arrivals and improve the efficiency of yard cranes. The proposed approach can significantly reduce container terminals’ truck waiting time.
Hybrid Lattice-Boltzmann-Potential Flow Simulations of Turbulent Flow around Submerged Structures
Authors: O’Reilly Christopher M. , Grilli Stephan T. , Janßen Christian F. , Dahl Jason M. , Harris Jeffrey C.
Published: November 2022

We report on the development and validation of a 3D hybrid Lattice Boltzmann Model (LBM), with Large Eddy Simulation (LES), to simulate the interactions of incompressible turbulent flows with ocean structures. The LBM is based on a perturbation method, in which the velocity and pressure are expressed as the sum of an inviscid flow and a viscous perturbation. The far- to near-field flow is assumed to be inviscid and represented by potential flow theory, which can be efficiently modeled with a Boundary Element Method (BEM). The near-field perturbation flow around structures is modeled by the Navier–Stokes (NS) equations, based on a Lattice Boltzmann Method (LBM) with a Large Eddy Simulation (LES) of the turbulence. In the paper, we present the hybrid model formulation, in which a modified LBM collision operator is introduced to simulate the viscous perturbation flow, resulting in a novel perturbation LBM (pLBM) approach. The pLBM is then extended for the simulation of turbulence using the LES and a wall model to represent the viscous/turbulent sub-layer near solid boundaries. The hybrid model is first validated by simulating turbulent flows over a flat plate, for moderate to large Reynolds number values, Re ∈[3.7×104;1.2×106]; the plate friction coefficient and near-field turbulence properties computed with the model are found to agree well with both experiments and direct NS simulations. We then simulate the flow past a NACA-0012 foil using a regular LBM-LES and the new hybrid pLBM-LES models with the wall model, for Re = 1.44×106. A good agreement is found for the computed lift and drag forces, and pressure distribution on the foil, with experiments and results of other numerical methods. Results obtained with the pLBM model are either nearly identical or slightly improved, relative to those of the standard LBM, but are obtained in a significantly smaller computational domain and hence at a much reduced computational cost, thus demonstrating the benefits of the new hybrid approach.
Effect of Flow-Dependent Unbalanced Background Error Variances on Tropical Cyclone Forecasting
Authors: Zhang Wei , Liu Bainian , Zhang Weimin , Li Shaoying , Cao Xiaoqun , Xing Xiang
Published: November 2022

The background error variance in variational data assimilation can significantly affect a model’s initial field. Around extreme weather events, the variance of the unbalanced control variables have contributed highly to the total variance. This study investigates the effect of flow-dependent unbalanced variance on tropical cyclone (TC) forecasts using the ensemble of data assimilation (EDA) method. The analysis of TC Saudel (October 2020) shows that flow-dependent unbalanced variances can better represent the uncertainty in the background error, which is investigated in terms of magnitude and distribution. The vertical distribution of the temperature-explained variance ratio also shows that the contribution of the vorticity-balanced variance around Saudel is lower than the global average (in the troposphere). Single-observation experiments reveal that the structured flow-dependent errors of unbalanced control variables can also introduce corresponding structural information in analysis increments. As expected, the experiments in which the variances of all variables are flow-dependent in the one-month TC forecast performed better overall. Compared with the reference, these forecasts reduce the average absolute track and intensity errors by approximately 31% and 9%, respectively. The results demonstrate that EDA-based unbalanced variances can indeed improve the mean forecast skills of TC tracks and intensities despite instability at some lead times by improving the forecast of the circulation situation and providing a more appropriate balance relationship between variables.
Towards Fuel Consumption Reduction Based on the Optimum Contra-Rotating Propeller
Authors: Tadros Mina , Ventura Manuel , Guedes Soares C.
Published: November 2022

This paper presents the effect of selecting a contra-rotating propeller (CRP) for a bulk carrier at the engine operating point with minimum fuel consumption, as well as ensuring the safety of the propeller in terms of cavitation and noise. Using a developed optimization model, the geometry of a CRP was selected for different propeller diameters, the same propeller diameter as that of a fixed pitch propeller (FPP) installed on the bulk carrier, and at 90% of the FPP diameter. Additionally, each case was optimized with both no-cup and heavy-cup configurations. In general, the CRP showed better performance than the FPP in terms of efficiency, cavitation, and fuel economy. At the same time, the level of performance was increased when considering the CRP cupping percentage. It was concluded that the CRP can achieve a gain in fuel economy of up to 6.2% in a no-cup configuration when compared to an FPP, and up to 11.7% with a cupped configuration.
Effects of Ultrasound-Guided Injection Combined with a Targeted Therapeutic Exercise in Breast Cancer Women with Subacromial Pain Syndrome: A Randomized Clinical Study
Authors: Lippi Lorenzo , de Sire Alessandro , Folli Arianna , Maconi Antonio , Polverelli Marco , Vecchio Carlo , Fusco Nicola , Invernizzi Marco
Published: November 2022

In this randomized controlled study, we aimed to assess the effects of US-guided injections of the subacromial bursa followed by a personalized rehabilitation program for breast cancer (BC) survivors. We assessed patients with subacromial pain syndrome without tendon lesions and with a history of post-surgical non-metastatic BC. Thirty-seven patients were enrolled and randomly assigned 1:1 to receive US-guided corticosteroid injections combined with a personalized rehabilitation program (Group A; n: 19) or US-guided corticosteroid injections alone (Group B; n: 18). The primary outcome was pain relief, assessed using a numerical pain rating scale (NPRS). The secondary outcomes were muscle strength, shoulder function, and quality of life. No major or minor late effects were reported after the multidisciplinary intervention. Statistically significant within-group differences were found in terms of NPRS (p ≤ 0.05) in both groups. No significant between-group differences were reported after one week. However, the between-group analysis showed significant differences (p ≤ 0.05) after three months of follow-up in terms of pain intensity, muscle strength, shoulder function, and quality of life. Our findings suggested positive effects of a multidisciplinary approach including US-guided corticosteroid injections combined with a personalized rehabilitation program in improving pain intensity and quality of life of BC survivors with subacromial pain syndrome.
What We Talk about When We Talk about Artificial Intelligence in Radiation Oncology
Authors: Cuccia Francesco , Carruba Giuseppe , Ferrera Guseppe
Published: November 2022

The constant evolution of technology has dramatically changed the history of radiation oncology, allowing clinicians to deliver increasingly accurate and precise treatments, moving from 2D radiotherapy to 3D conformal radiotherapy, leading to intensity-modulated image-guided (IMRT-IGRT) and stereotactic body radiotherapy treatments [...]
The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study
Authors: Kuo Shu-Jui , Siu Ka-Kit , Wu Kuan-Ting , Ko Jih-Yang , Wang Feng-Sheng
Published: November 2022

Distal femur reaming-free total knee arthroplasty (TKA) was reported to possess lower risk of acute myocardial infarction (AMI) or venous thromboembolism (VTE) than conventional TKA in a retrospective population-based study. We tried to offer prospective biological evidence by comparing the levels of AMI and VTE serum surrogate markers among the patients undertaking navigation and conventional TKAs to support these observations. Thirty-four participants undertaking navigation TKA and 34 patients receiving conventional TKA were recruited between February 2013 and December 2015. Blood samples were drawn from all participants before TKA, and 24 and 72 h after TKA, to assess the concentration of soluble P-selectin, matrix metalloproteinase-9 (MMP-9), C-reactive protein (CRP), and interleukin-8 (IL-8) between the participants undergoing navigation and conventional TKAs. We showed that significantly lower serum levels of soluble P-selectin 24 h after, as well as CRP 24 and 72 h after TKA could be observed in the navigation cohort. The more prominent surge of serum soluble P-selectin and CRP were perceived 24 and 72 h after TKA among the participants undergoing conventional TKA. Based upon our prospective biological evidence, the merits of navigation TKA are strengthened by lower levels of AMI and VTE serum surrogate markers.
Dynamic Plasma Lipidomic Analysis Revealed Cholesterol Ester and Amides Associated with Sepsis Development in Critically Ill Patients after Cardiovascular Surgery with Cardiopulmonary Bypass
Authors: Ding Wenyan , Xu Shaohang , Zhou Baojin , Zhou Ruo , Liu Peng , Hui Xiangyi , Long Yun , Su Longxiang
Published: November 2022

Background: Sepsis in patients after cardiovascular surgery with cardiopulmonary bypass (CPB) has a high rate of mortality. We sought to determine whether changes in lipidomics can predict sepsis after cardiac surgery. Methods: We used high-performance liquid chromatography coupled to tandem mass spectrometry to explore global lipidome changes in samples from a prospective case-control cohort (30 sepsis vs. 30 nonsepsis) hospitalized with cardiovascular surgery. All patients were sampled before and within 48–72 h after surgery. A bioinformatic pipeline was applied to acquire reliable features and MS/MS-driven identifications. Furthermore, a multiple-step machine learning framework was performed for signature discovery and performance evaluation. Results: Compared with preoperative samples, 94 features were upregulated and 282 features were downregulated in the postoperative samples of the sepsis group, and 73 features were upregulated and 265 features were downregulated in the postoperative samples of the nonsepsis group. “Autophagy”, “pathogenic Escherichia coli infection” and “glycosylphosphatidylinositol-anchor biosynthesis” pathways were significantly enriched in the pathway enrichment analysis. A multistep machine learning framework further confirmed that two cholesterol esters, CE (18:0) and CE (16:0), were significantly decreased in the sepsis group (p < 0.05). In addition, oleamide and stearamide were increased significantly in the postoperative sepsis group (p < 0.001). Conclusions: This study revealed characteristic lipidomic changes in the plasma of septic patients before and after cardiac surgery with CPB. We discovered two cholesterol esters and two amides from peripheral blood that could be promising signatures for sepsis within a dynamic detection between the preoperative and postoperative groups.
[18F]FDG PET/CT in Patients Affected by SARS-CoV-2 and Lymphoproliferative Disorders and Treated with Tocilizumab
Authors: Signore Alberto , Lauri Chiara , Bianchi Maria Paola , Pelliccia Sabrina , Lenza Andrea , Tetti Simone , Martini Maria Luisa , Franchi Gabriele , Trapasso Fabio , De Biase Luciano , Aceti Antonio , Tafuri Agostino
Published: November 2022

Objectives: Interstitial pneumonia is a severe complication induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several treatments have been proposed alone or, more often, in combination, depending, also, on the presence of other organ disfunction. The most frequently related, well-described, and associated phenomenon is pan-lymphopenia with circulating, high levels of cytokines. We report, here, on two patients with COVID-19 and lymphoproliferative disorders treated with Tocilizumab (a humanized monoclonal antibody against the interleukin-6 receptor) and followed by an [18F]FDG PET/CT to early evaluate the therapy’s efficacy. Methods: One patient with angioimmunoblastic T-lymphoma (A), one with Hodgkin lymphoma (A), and both with positive RT-PCR for SARS-CoV-2 and with similar clinical findings of interstitial pneumonia at the CT scan, were imaged by [18F]FDG PET/CT before and 14 days after a single dose of Tocilizumab. Results: In both patients, the basal [18F]FDG PET/CT showed a diffused lung parenchyma uptake, corresponding to the hyperdense areas at the CT scan. After 2 weeks of a Tocilizumab infusion, patient B had an improvement of symptoms, with normalization of the [18F]FDG uptake. By contrast, patient A, who was still symptomatic, showed a persisting and abnormal distribution of [18F]FDG. Interestingly, both patients showed a low bone marrow uptake of [18F]FDG at the diagnosis and after 15 days, while the spleen uptake was low only in lymphopenic patient A; both are indirect signs of an immune deficiency. Conclusions: In conclusion, in these two patients, interstitial pneumonia was efficiently treated with Tocilizumab, as demonstrated by the [18F]FDG PET/CT. Our results confirm that interleukin-6 (IL6) has a role in the COVID-19 disease and that anti-cytokine treatment can also be performed in patients with lymphoproliferative disorders.
Immunogenic Cell Death (ICD)-Related Gene Signature Could Predict the Prognosis of Patients with Diffuse Large B-Cell Lymphoma
Authors: Ping Liqin , He Yanxia , Gao Yan , Wang Xiaoxiao , Huang Cheng , Bai Bing , Huang Huiqiang
Published: November 2022

Background: Diffuse large B-cell lymphoma (DLBCL) is the most prevalent type of lymphoma that is potentially curable by chemotherapy. Immunogenic cell death (ICD) is regarded as an essential process for the clearance of residual tumor cells. However, the impact of ICD on DLBCL remains unknown. Here, we tried to explore the prognostic role of ICD in DLBCL. Methods: A gene expression microarray of DLBCL was downloaded from the Gene Expression Omnibus (GEO). The genes involved in ICD were obtained via literature reviews. Then, based on univariate, multivariate, and LASSO Cox regression analysis, the ICD-related gene signature was identified. The effect of the ICD-related gene signature on DLBCL was explored. The chi-square test was used to compare complete response rate (CRR) and recurrence rate between high- and low-risk groups. Results: The signature based on 12 ICD-related genes could independently predict the overall survival of DLBCL. Furthermore, high risk was linked to lower CRR and higher recurrence rate. Then, a nomogram based on the ICD-related gene signature was established. The area under the curve of the prediction model reached 0.820 in the training set and 0.780 in the validation set. Conclusions: This study suggested that the ICD-related gene signature could be a novel prognostic indicator for DLCBL.
Positioning and Web Traffic of Colombian Banking Establishments
Authors: Rojas Rincón Joan Sebastián Rojas , Riveros Tarazona Andrés Ricardo Riveros , Mejía Martínez Andrés Mauricio Mejía , Acosta-Prado Julio César
Published: November 2022

The use of digital technologies has become one factor that significantly impacts business results in the financial industry. This study seeks to characterize the positioning and web traffic of Colombian banking establishments through analysis of the classification of their website, taking as reference the metrics related to web traffic and the attractiveness of the content and relevance for users as the bounce rate. The study presents a quantitative approach, non-experimental design, and descriptive scope. With a sample of 28 banking establishments, it is intended to contribute to the body of literature on bank marketing based on a systematic analysis of indicators. The findings of the study made it possible to elucidate that a good part of the websites of the banking establishments is well positioned, in addition to presenting low bounce rates. It is also possible to show that a significant portion of this traffic comes from individuals between 18 and 34 years of age and of the female gender. Likewise, traffic to the website is derived to a greater extent from direct access to the establishment’s portal or search engines.
Does Digital Transformation Promote Agricultural Carbon Productivity in China?
Authors: Xu Ning , Zhao Desen , Zhang Wenjie , Liu Ming , Zhang He
Published: November 2022

Against the background of global climate change and the rapid rise of the digital economy, the digital transformation of agriculture is profoundly changing the agricultural production and operation mode with the help of digital technology, becoming a new driving force for low-carbon and sustainable development of agriculture. However, previous studies rarely examined the impact of agricultural digital transformation on agricultural low-carbon transformation from the perspective of carbon productivity. To fill this gap, this study attempts to build a theoretical analysis framework for the impact of agricultural digital transformation on agricultural carbon productivity (ACP). By using a set of panel data from 30 provinces (cities) in China from 2011 to 2019, this study explores the impact of agricultural digital transformation on ACP, as well as its conduction mechanism and the non-linear mechanism. Empirical results show that the transformation of agricultural digitalization is conducive to the promotion of ACP. A series of robustness analyses support this conclusion. The main transmission mechanisms for digital transformation to affect ACP include agricultural industrial structure upgrading, and the agricultural scale operation. In addition, with the improvement of urbanization level and rural human capital, the impact of agricultural digital transformation on ACP presents a “U” type non-linear feature of inhibition first and promotion later. Furtherly, heterogeneity analysis shows that the impact of digital transformation on ACP will vary greatly depending on the levels of ACP, the geographical location of the studied area and whether it is a main grain-producing area. This study provides a theoretical and empirical basis for the improvement of China’s agricultural carbon productivity from the perspective of the digital economy.
Debt-Driven Property Boom, Land-Based Financing and Trends of Housing Financialization: Evidence from China
Authors: Li Jia , Tochen Rachel , Dong Yaning , Ren Zhuoran
Published: November 2022

To cope with the global financial crisis, China’s governments issued huge amount of debt to support public infrastructure projects. These financing mechanisms brought about rapid economic restoration, as well as large amounts of debt accumulation. Among other outcomes of this were increasing the leverage in property markets and advancing the extent of financialization in China’s local economy. Financialization level measures the proportion of the total volume of financing provided by the financial system to the real economy, which covers all the generated debts connecting within real economy and financial system. In this study, we outline the mechanism of housing-centered debt expansion process, land-based financing for local governments and trends of housing financialization in local China. Most importantly, the functions of land in such mechanism is highly emphasized. We run fixed-effect and random-effect models to testify the correlation between the kernel variables—financialization level and real estate investment and public infrastructure. To lower the endogenous problems in the estimation, we use instrumental variables (IV) methods and estimate by the two-stage OLS (2SLS) method. The results show that 1% increase (or decrease) of financialization level (measured by the indicator of Aggregate Financing to Real Economy as percentage of GDP) brings about a significant increase (or decrease) of 48% of real estate investment and 59% of public infrastructure investment nationally. Based on the results, we deduce an overview of debt-driven mechanism in China’s local economy named dual financing circulation, which contains two parallel financing circuits, governmental financing based on lands as collateral and market financing based on properties. Finally, the study reveals some new trends of financialization in property markets. Therefore, the major originality of paper is theoretically combining the governmental and private financing circuits as a whole framework for better understanding the financialized local economy of China and putting forward some policy implementations, such as reducing and setting ceilings on leverage of real estate developers in China.
Modelling Initiation Stage of Backward Erosion Piping through Analytical Models
Authors: Luo Guanyong , Rice John D. , Peng Sige , Cao Hong , Pan Hong , Xu Guoyuan
Published: November 2022

Backward erosion piping, which is one of the leading causes of levee and dam failures, is more likely to occur when a flow is concentrated on a defect with an overlying low-permeability layer and a shallow erosion channel forming and progressing towards a seepage source. Two analytical models are presented to allow assessment of the seepage regime on the initiation stage of BEP. The variations between the two models are analysed, indicating that the effects of soil loosening have a major role in the assessment of BEP mechanisms. This paper also describes the reliability of using Xiao’s model in 3D analysis, which includes results and parametric analysis. Although the head in front of the tip of the erosion channel can be predicted by this accepted calculation model, which is essential for laboratory work on this topic, the model also has range and boundary limitations that need to be addressed for general prediction when BEP progresses with channel development.
Characteristics and Driving Forces of Symbiosis between Production Land and Living Land in Rural Settlement: Evidence from Shanxi Province, China
Authors: Zhang Bailin , Zhai Bingqian , Gao Jinyun , Lian Xiaoyun
Published: November 2022

Rural settlements are the carrier of farmers’ life and rural industries. This paper introduces symbiosis theory to construct an analytical framework for the symbiosis between production land and living land in rural settlements, taking three villages in Shanxi, China as examples (secondary industry-led: Tian Village, tourism-led: Shuiyukou Village, multi-industry integration: Jiling Village). The results show that: (1) From 2010 to 2020, the compatibility and coupling coordination degree between production land and living land in Tian Village increased; the compatibility degree between production land and living land in Shuiyukou Village decreased slightly, and the coupling coordination increased significantly. In Jiling Village, the compatibility between production land and living land decreased, and the coupling coordination showed an increasing trend. (2) From 2010 to 2020, the degree of symbiosis between production land and living land in the three Villages both showed an increasing trend, and the growth of symbiosis degree was mainly caused by the growth of coupling coordination. (3) In 2010–2015 and 2015–2020, the symbiotic growth between production land and living land in Tian Village was driven by farmers’ demand and social economy, respectively. The dominant driving factor for Shuiyukou Village in these two periods was resource endowment. Jiling Village was driven by social economy and regional policies, respectively. This work can provide scientific support for the practical adjustment of land use structure and the reconstruction of rural settlements in China.
Impacts of Extension Contact on the Adoption of Formulated Fertilizers and Farm Performance among Large-Scale Farms in Rural China
Authors: Xu Zengwei , Li Jing , Ma Jiliang
Published: November 2022

Growing concerns about the environmental costs of agricultural production have given new impetus to the promotion of sustainable agricultural production technologies that can reduce soil erosion and the excessive use of agricultural chemicals. Although numerous policies have been implemented to popularize soil testing and formulated fertilization technologies in China, the diffusion of the technology among large-scale farmers (LSFs) has been addressed only rarely. We used a two-stage controlled function model to control for endogeneity and selection bias in contacting extension staff to assess the effect of an extension contact on technology adoption behavior by LSFs, Propensity Score Matching techniques are also utilized to analyze the effects of extension contact on the rice yields and nutrient use amount. Empirical results from Jiangsu and Jiangxi provinces show that extension contact plays a crucial role in promoting soil testing and the adoption of formulated fertilization technologies; LSFs’ adoption raises rice yields, however, the impact of extension contact on reducing nutrient use amount does not pass the significance test. The findings add to the theoretical literature on technology extension, and we used them to suggest policies to encourage tailored agricultural extension systems by constructing rural technological extension networks.
Systemic Sclerosis and Idiopathic Portal Hypertension: Report of a Case and Review of the Literature
Authors: Colaci Michele , Aprile Maria Letizia , Sambataro Domenico , Sambataro Gianluca , Malatino Lorenzo
Published: November 2022

The presence of liver involvement in systemic sclerosis (SSc) is considered atypical, besides the possible coexistence of other autoimmune hepatic disorders. However, the occurrence of portal hypertension and, more specifically, of the syndromes called idiopathic portal hypertension (IPH) and regenerative nodular hyperplasia (RNH) have been anecdotally reported in the literature for SSc patients. We described a case of SSc woman complicated by IPH; moreover, we reviewed the literature on the topic. A 61-year-old female SSc patient was admitted to our hospital because of the onset of ascites. SSc, as a limited skin subset of disease with anticentromere antibodies, was diagnosed 11 years previously, with no significant visceral involvement. We excluded possible causes of portal hypertension, namely chronic infections, autoimmune hepatic diseases, neoplasia, thrombosis of portal vein, and Budd–Chiari syndrome. Finally, IPH was diagnosed. A review of the literature identified a number of case reports or case series that described IPH in the course of SSc. No specific SSc pattern linked to IPH emerged, even though reports from the literature often described the limited skin subset. Coexistence of prothrombotic states and overlap with other hepatic diseases could facilitate IPH onset. Besides being a rare condition, the onset of IPH in SSc patients is an occurrence that should be taken into account.
4,4′-([1,2,5]Thiadiazolo[3,4-d]pyridazine-4,7-diyl)bis(N,N-bis(4-methoxyphenyl)aniline)
Authors: Chmovzh Timofey N. , Kudryashev Timofey A. , Rakitin Oleg A.
Published: November 2022

Donor-acceptor-dyes with extended conjugation, such as D–π–A–π–D type, are being intensively investigated as components of near-infrared (NIR) organic light-emitting diodes (OLEDs). In this communication, novel D–π–A–π–D dye, 4,4′-([1,2,5]thiadiazolo[3,4-d]pyridazine-4,7-diyl)bis(N,N-bis(4-methoxyphenyl)aniline), was synthesized by Stille cross-coupling reaction of 4,7-dibromo-[1,2,5]thiadiazolo[3,4-d]pyridazine. The structure of newly synthesized compounds was established by elemental analysis, high-resolution mass-spectrometry, 1H, 13C NMR, IR, and UV spectroscopy. The photophysical properties of the title compound were studied.