bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Ekstrak Rasberi (Rubus occidentalis) terhadap Kadar Asam Urat Tikus Wistar Model Sindrom Metabolik
Authors: Phangadi Milana , Subandono Jarot , - Sarsono
Published: September 2022

Pendahuluan: Sindrom metabolik yang mencakup hiperinsulinemia, hiperkolestrolemia, dislipidemia, hipertensi, dan juga obesitas dapat memengaruhi kadar asam urat dalam tubuh seseorang. Hiperinsulinemia akan menyebabkan gangguan metabolisme asam urat yang menyebabkan kondisi hiperurisemia. Rasberi merupakan buah yang kaya antosianin yang merupakan flavonoid natural yang menunjukan efektivitas dalam pengobatan sindrom metabolik namun efektivitasnya terhadap kadar asam urat masih kurang banyak diteliti. Penelitian ini bertujuan untuk membuktikan efektivitas rasberi dalam menurunkan kadar asam urat serta melihat pengaruh perbedaan dosis ekstrak rasberi terhadap kadar asam urat pada tikus wistar sindrom metabolik.
Metode: Penelitian ini merupakan penelitian eksperimental laboratorik dengan sampel 30 tikus Wistar dalam 5 kelompok (kontrol dan perlakuan). Tikus diinduksi diet HFFD selama 28 hari lalu diinjeksi STZ-NA dan diukur kadar asam uratnya (pretest) bersama dengan parameter lain (berat badan, glukosa, HDL, dan kolesterol total) untuk memastikan sampel memenuhi kriteria sindrom metabolik. Selanjutnya kelompok perlakuan diberi ekstrak rasberi (Rubus occidentalis) dengan dosis 125 mg/kgBB, 250 mg/kgBB, dan 375 mg/kgBB selama 21 hari lalu diukur kadar asam uratnya (posttest). Kadar asam urat didapat melalui serum darah vena retroorbital yang dianalisis dengan kit DiaSys. Kadar asam urat pretest dan posttest kelompok kontrol dan perlakuan dianalisis menggunakan uji T berpasangan dan One Way ANOVA.
Hasil: Kadar asam urat posttest menurun sebesar 6,39 mg/dL,  7,58 mg/dL, dan 8,74 mg/dL pada kelompok perlakuan. Terdapat perbedaan signifikan (p<0,05) antara rerata kadar asam urat pretest dan posttest serta rerata antar kelompok.
Kesimpulan: Rasberi (Rubus occidentalis) dapat menurunkan kadar asam urat dalam darah dan efeknya semakin besar sebanding dengan jumlah dosis yang diberikan.
Kata Kunci: Sindrom Metabolik, Rasberi (Rubus occidentalis), Asam Urat, Tikus Wiztar
How will the Legal Battle End in the Public Job : Sight of Jordan Issue
Authors: Mohsen Mohammed bin Treef Mohammed Abdul , Alsaleh Ibtsam , Alasaf Kamal Mohamoud , Alfadhlei Hiba Abdulmyuttaleb
Published: September 2022

Conflict of interests, as an act of corruption, is considered a loose concept. Legal jurisprudence differed in defining its concept, but the salient feature in it is that it constitutes an act of a public job that calls for both disciplinary and criminal responsibility, as it constitutes a two-faced act, a criminal and a disciplinary aspect. This study came to examine a important issue within the framework of the public job. From here it was necessary to stand on the definition of conflict of interest and the types of this conflict within the framework of the public job, and the elements of the crime of conflict of interest according to the criminal framework in the punitive legislation in the countries under study. The main findings show that the most prominent of which is that the most common and dangerous form of conflict is the conflict between the public interest and the private interest. This is when the employee has a direct or indirect interest that affects the administrative decision-making process or any other administrative act. The two researchers recommended that more details be given to the images of Conflict of interests in order to avoid any legal lapse or loophole, which would result in the establishment of the largest possible criminal and disciplinary confrontation for this act.
Deliberating the Constitutional Supremacy from Legal Perspective in Palestine
Authors: Hamad Ahmed M.A , Anuar Haslinda Binti Mohd.
Published: September 2022

The system of government considers constitutional supremacy in which the freedom of the legislature of parliamentary supremacy relinquishes to the requirements of a constitution. This article examines the constitutional supremacy of basic law from the legal and judicial perspective, particularly concerning the Palestinian situation. In addition, constitutions differentiate according to whether they are codified or not into written constitutions and unwritten constitutions. Besides, constitutions differ in how they are amended into flexible and rigid constitutions. Palestinian Basic Law of 2003 is not explicitly provided with any legal provision or article in the Basic Law about the principle of constitutional supremacy or the supremacy of the basic law. However, some elements and legal provisions or articles could make the Basic Law supreme. The article aims to clarify the decline of the concept of constitutional supremacy or the supremacy of the basic law from the legal and judicial perspective, with particular reference to the Palestinian situation. Moreover, constitutional oversight secured the supremacy of the Basic Law of 2003. These main findings show that the Palestinian Basic Law of 2003 has adopted the principle of supremacy of the Basic Law of 2003 over ordinary laws and subsidiaries within the state of Palestine. The article also emphasises the need to explicitly mention the principle of constitutional supremacy or the supremacy of the basic law by amending the Basic Law of 2003
EVALUATION MODEL OF THE RECOVERY PROCESSES OF NON-MARKOVIAN SYSTEMS, CONSIDERING THE ELEMENTS UNRELIABILITY UNDER ARBITRARY DISTRIBUTION LAWS
Authors: Raskin Lev , Ivanchikhin Yuriy , Sukhomlyn Larysa , Sviatkin Iaroslav , Korsun Roman
Published: September 2022

The subject of the study is the reliability of recoverable non–Markovian systems, functioning of which is described by arbitrary distribution laws. The purpose of the article is to develop a mathematical model of the functioning of modern computer systems under arbitrary laws of the distribution of stay duration in each of the states, taking into account the recovery system and the provision of spare elements. The main task is to develop an adequate model of the system functioning process, taking into account the non-Markovian character of the processes occurring in the system, its possible large dimension, and the presence of a hierarchical recovery system. Based on this model, a method for calculating the density of the system recovery time distribution has been developed. At the same time, a universal four-parameter distribution is proposed to describe random processes occurring in the system. Using this approximation, the calculation of the desired parameter of the recovery flow is performed by solving the Volterra integral equation with a difference kernel.
DEVELOPMENT OF AN IMPROVED HIERARCHICAL CONTROL SYSTEM USING THE METAHEURISTIC PID TUNER FOR DC MICROGRIDS
Authors: Yusubov Elvin , Bekirova Lala
Published: September 2022

This paper presents the development of the improved hierarchical control system using the metaheuristic centralized PID tuner for DC microgrids. Hierarchical control is one of the best control strategies employed in photovoltaics (PV) based DC microgrids with three layers of primary, secondary, and tertiary controllers in which PID control is at the center of each one of these three layered control levels. The principal objective of the primary controller is to ensure near-equal power sharing among the units and of the secondary controller is to correct the deviations in the common DC link, while the tertiary controller is used to manage the energy flow among DC microgrids or between DC microgrid and the main utility grid. Partial shading, the uncertain nature of solar irradiation, and varying temperatures significantly reduce the overall power efficiency of traditionally tuned PID control-based hierarchical systems, since the tuning gains of these PID controllers are not adaptive to the dynamic processes. To optimize the control process, a novel hierarchical system is considered in which PID gains of primary, secondary, and tertiary controllers are tuned with metaheuristic moth-flame optimization to adapt to the variations. Matlab/Simulink simulations are performed to verify the efficiency of the proposed approach. The results highlight the superiority of the proposed method by utilizing process adaptive gains.
Effect of Health Behaviors Practice on Mental Health in Adolescents
Authors: Yun Hyun Jung
Published: September 2022

Objectives: The study aimed to investigate the effect of health behaviors practice on mental health in adolescents. Methods: Data from 16th (2020) Korea Youth Risk Behavior Web-based Survey were used. The study sample included 54,948 middle and high school students. The data were analyzed using Rao-Scott χ2, t-test, and complex samples logistic regression. Results: The prevalence of subjects with anxiety, depression, and suicidal ideation was 9.2%, 25.2%, and 10.9%, respectively. Health behaviors practice such as smoking, drinking, weight control, exercise, eating breakfast, sufficient sleep, and fruit intake were found to be significantly related to mental health. After controlling general characteristics, mental health factors such as anxiety, depression, and suicidal ideation were influenced by health behaviors practice. Conclusions: Interventions, including comprehensive health behaviors, should be strengthened to prevent mental health problems in adolescents.
Effects of a Lumbar Stabilization Exercise Program on Low Back Pain, the Oswestry Disability Index, Use of Body Mechanics, and Lumbar Strength among Intensive Care Unit Nurses
Authors: Jang Hae Mi , Park Hye-Ja
Published: September 2022

Objectives: This study examined the effects of a lumbar stabilization exercise program on low back pain, the Oswestry Disability Index, use of body mechanics, and lumbar strength among intensive care unit nurses. Methods: Thirty-five nurses were assigned to an exercise group (n = 18) or a control group (n = 17) from a university hospital-affiliated intensive care unit. The 8-week lumbar stabilization exercise program comprised 30 minutes of stretching, lumbar stabilization exercise, and Mckenzie extension exercise (3 times/week) and a single education session on body mechanics. Outcomes were assessed using questionnaires on low back pain (visual analogue scale), the Oswestry Disability Index (%), use of body mechanics, and back strength (kg). Data were analyzed by χ²-test, independent t-test, and analysis of covariance. Results: The lumbar stabilization exercise program provided improvements in low back pain, the Oswestry Disability Index, use of body mechanics, and back strength Conclusions: Lumbar stabilization exercise program might be a useful strategy for enhancing usage of work-related body mechanics and back muscle strength, and ameliorating low back pain and disability index for nurses working at the intensive care units.
Predictive Models and Visualizations according to Outcome Variables Using R – Focusing on Regression Analyses
Authors: Yang Juyeon , Jeon Soyoung , Lee Hye Sun
Published: September 2022

Predictive models have recently become increasingly important across various fields. In particular, in clinical research, the main purpose is to build a model that can find risk factors and predict a specific disease. Predictive models can help clinicians make fast and accurate decisions by capturing relationships between multiple factors related dependent variables. Accordingly, this paper describes a predictive model construction method and visualization that can be useful in clinical research. As dependent variables can be divided into continuous, categorical, and survival variables, the concepts and principles of linear, logistic, and cox regression analyses for building predictive models are explained in this paper. In addition, we investigated how to select variables to create an optimal model and how to evaluate the discrimination and calibration of the model. A visualization method that can help interpret according to each regression analysis model is also described. This paper will provide basic knowledge for clinical researchers to more easily build predictive models and evaluate them for practical use.
How to Use Health Insurance Data Effectively for Healthcare Research
Authors: Park Ilsu
Published: September 2022

Objectives: The purpose of this study is to present an understanding of the structure and characteristics of health insurance data, which should be basically known in order to use this data more effectively to derive more accurate research results across health and medical care, and an effective use method based on it. Methods: The National Health Insurance Sharing Service and Healthcare Big data open system was reviewed to suggest the structure and characteristics of health insurance data and an efficient use method, and Google Scholar and the Korean Studies Information Service System were used to review the overall application method according to the characteristics of healthcare big data and related literature. Results: The types and characteristics of each research data for public use provided by National Health Insurance Service (NHIS), Health Insurance Review & Assessment Service (HIRA), and the differences between the data of the two institutions were compared and presented. In addition, for the efficient use of health insurance data in healthcare research, understanding the structure and characteristics of health insurance data based on the health insurance system, clear operational definition of analysis variables, adjust bias between comparison groups in case-control study, and the interpretation of analysis results suggest that both statistical and clinical significance should be considered. Conclusions: It is very important to understand the structure and characteristics of health insurance data based health insurance system. And if we consider in more depth ways to efficiently utilize the health insurance data presented in this study, it will be of great help to future researchers and to improve the quality of the research.
Far-Lateral Cervical Approach as a Minimally Invasive Technique for Excision of Upper Cervical Anterolateral and Anterior Meningiomas and Dumbbell Schwannomas: Technical Report and Case Series
Authors: Abou-Madawi Ali M , Ali Sherif H , Mahmoud Mohamed H , Elkazaz Mohamed K , Abdelaziz Mohamed A , Elsayed Khaled , Alshatoury Hassan A
Published: September 2022

Objective: To demonstrate the surgical details of the far-lateral approach (FLA) as a minimally invasive technique for the excision of the upper cervical anterolateral and anterior meningiomas and dumbbell schwannomas, and to assess the clinical and radiological outcomes in patients who underwent surgery.Methods: In this technical report and case series we demonstrated the FLA technique and reported patients who underwent the FLA for C1-C4 anterolateral and anterior meningiomas and dumbbell schwannomas between June 2007 and June 2020. All patients’ relative preoperative demographic, clinical, radiographic, operative, histopathological, and perioperative complications and follow-up clinical and radiographic data were reported.Results: A total of 19 patients including 12 females and 7 males with a mean age 56.7±17.6 years and mean duration of symptoms 12.8±12.3 months were reported. Nine patients with anterolateral meningiomas, five with anterior meningiomas, and 5 with dumbbell schwannomas underwent uneventful FLA procedures. Gross total resection (GTR) of tumors was reported in 17 patients (89.5%). Preoperative Japanese Orthopedic Association (JOA) score was normal in ten, grade-I in five, and grade-II in 4 patients, while at the last follow-up it improved to normal in seventeen and grade-I in two patients. Reported postoperative JOA scores at 6 months and at the last follow-up showed that all patients improved at least one grade on JOA scores. There was cerebrospinal fluid (CSF) leak into the suction drain in three patients and superficial wound infection in another one.Conclusion: Our results advocate the use of the far-lateral cervical approach as a minimally invasive technique in the resection of the upper cervical anterolateral and anterior meningiomas and dumbbell schwannomas as a safe and effective technique.
Preoperative Stiffness is the most important Predictor of Postoperative Patient’s Satisfaction after Total Knee Arthroplasty.
Authors: Abdelhameed Mohammed Anter , Abdelnasser Mohammad Kamal , Zaky Bishoy Raafat , Bakr Hatem M. , Aziz Mirette , Mahran Mohamed
Published: September 2022

Purpose
to predict the most important preoperative factor affecting the patient satisfaction after total Knee arthroplasty (TKA) in trial to improve patient counselling process.
Methods
we retrospectively reviewed all patients who underwent primary TKA from 1st of January 2018 to 31st of January 2019 with minimum one year follow up for the previously collected patient reported outcome measures (PROMs) as Oxford Knee Score (OKS) and Knee Injury and Osteoarthritis Outcome Score for joint replacement (KOOS, JR) preoperative, 6 months and 12 months postoperative.
Results
By using Oxford knee score at 12 months as dependent variable, we found a negative moderate spearman correlation between age and oxford score at 12 months postoperative. Moderate negative spearman correlation was also found between oxford score at 12 months postoperative and KOOS pain, stiffness and function scores at preoperative and 6 months postoperative, denoting higher satisfaction at 12 months with less perceived stiffness, pain and limited function at baseline and 6 months postoperative. A multivariate regression analysis was done using the oxford knee score at 12 months as dependent variable to detect the predictors of oxford knee score at 12 months postoperatively and showed that younger age and less perception of stiffness at baseline were significant predictors of higher oxford score; higher satisfaction at 12 months postoperative.
Conclusion
Preoperative stiffness can predict the postoperative satisfaction score more than any other factor. We also address the importance of combining more than one PROM in assessing patients as OKS and KOOS, JR.
SymSwarm: A Two-Staged Decentralized Symmetrical Pattern Formation Paradigm for a Swarm of Mobile Robots
Authors: Istiak Md. Abrar , Ullah Md Saheed , Ashraf Zulqarnain Bin , Sarker Sudipta Chandra , Chowdhury Mortuza Minhaj , Ahbab Sadman Sakib
Published: September 2022

For several decades, cooperative control of autonomous mobile robots has been an active research area with potential applications in dynamic areas such as agriculture, industrial plants, and the military. Although numerous research studies on pattern formation using multiple mobile agents have been conducted, no algorithm for symmetric pattern formation that is independent of the number of agents and prioritizes user control has been introduced. This article demonstrates an attempt to manifest an end-to-end symmetrical pattern in a swarm of mobile robots. Here, a two-staged paradigm named SymSwarm is developed, which incorporates the novelty of forming symmetrical formations around a point within a coveted area via decentralized communication among the swarm. SymSwarm is built on a novel concept of a bio-inspired state model called CPSM (Compete and Point State Model), which enables smarter and more robust computation, and self-regulation. While most bio-inspired models focus on the characteristics of bees, ants, cats, chimps, and a variety of other animals, this paradigm focuses on the competitive sentiment and leadership ability of human beings to shape the CPSM mentioned above. The algorithm for acquiring symmetrical points is developed using the Circle Polygon analogy in cartesian geometry. The following sections propose a decentralized communication mechanism for adjacent consecutive robots, as well as a SymSwarm: A Two-Staged Decentralized Symmetrical Pattern heuristic nearest point finder algorithm. The proposed paradigm is evaluated using a robotics simulator (V-REP), and the results indicate that it is consistently successful and has a low rate of pattern formation error in the presence or absence of obstacles in the environment.
Cationic liposomes as promising vehicles forTimolol/Brimonidine combination ocular delivery in glaucoma: Formulation development and in vitro/in vivo evaluation
Authors: zadeh behzad sharif makhmal , Feghhi Mostafa
Published: September 2022

Glaucoma is a chronic eye disease in which the pressure inside the eye increases and leads to damage to the optic nerve, and eventually causes blindness. In this disease, it is often necessary to use a multi-drug treatment system. There is a fixed combination of Timolol maleate and Brimonidine tartrate among the combination drugs in glaucoma treatment. Liposomes are one of the most important targeted drug delivery systems to eye tissue, which leads to improved drug permeability and durability in ocular tissue.In this study, Thin Layer Hydration was used to make liposomal formulations containing Timolol maleate (TM) and Brimonidine tartrate (BT). After the necessary evaluations, one of the eight initial formulations was selected as an optimization formulation. Then, characteristics such as drug loading percentage, particle size, pH, zeta potential, and drug release were performed on the optimized formulation. The study of reducing intraocular pressure was performed on the optimized formulation. This study in total was performed on 18Rabbits in three groups. Hydroxypropyl methylcellulose (HPMC) polymer was injected into the anterior chamber to Experimental induce glaucoma.The selected formulation was within the acceptable range of ocular products in terms of physical properties. HPMC polymer injection successfully induced glaucoma in the animal model, resulting in a 79% increase in intraocular pressure. The results showed that the liposomal formulation significantly reduced the intraocular pressure compared to the simple formulation of the aqueous solution, and both formulations were able to significantly reduce the intraocular pressure compared to the control group(p < 0.001). The results also showed that liposomal formulation hasa therapeutic effect in reducing intraocular pressure and has a preventive effect and intraocular pressure return to normal value after 90 h. It seems that selected liposomal formulation made by Thin Layer Hydration can act as a suitable drug carrier to increase the effectiveness of the fixed combination of Timolol maleate and Brimonidine tartrate and be proposed as a new drug formulation for targeted and controlled drug delivery in the treatment of glaucoma.
Effect of different weekly frequencies of Chen-style Tai Chi in elders with chronic non-specific low back pain: Study protocol for a randomised controlled trial
Authors: Wan Ruihan , Shi Jian , Wang Yafei , Hu Kun , Jiang Xue , Yan Wangwang , Cao Mali , Wang Yuling
Published: September 2022

Background: Tai Chi (TC), as one of mild to moderate exercise therapies specifically recommended by multiple clinical guidelines, is a viable option for chronic non-specific low back pain (CNLBP) treatment. Nevertheless, limited studies focused on the effect of different weekly frequencies of TC in elders with CNLBP. This study aims to compare the differences of TC with different weekly frequencies in elders with CNLBP on the premise of proving its effectiveness, and to identify whether mindfulness mediates the effect of TC on treatment outcomes.
Methods: Totally 148 senior citizens aged 60 years old or above with CNLBP (as defined by the National Institutes of Health criteria) will be recruited in this single-centre, randomised, single-blinded, parallel controlled trial and conducted in the Sports Centre of Changsha First Social Welfare Institute, Hunan Province, China. Participants will be randomly divided into four groups: three different weekly frequencies Chen-style TC groups (1, 3, and 5 sessions/week, 60min/session, sustain for 12weeks on the basis of weekly health educational lecture), whereas the control group will only undergoweekly healthy educational lecture. Three months of follow-up visits will be conducted. The primary outcome is pain intensity, which will be measured at baseline, after every four weeksof intervention, and after the follow-up period via Visual Analogue Scale (VAS). Secondary outcomes include Beck Depression Inventory-II (BDI-II), Pain Catastrophising Scale (PCS) and Five Facet Mindfulness Questionnaire (FFMQ), Oswestry Disability Index (ODI), and Short Form-36 (SF-36), which will be measured before and after intervention and after the follow-up period. The intention-to-treat and per-protocol principles will be used to analyse primary and secondary outcomes with a setting at α = 0.05 as statistical significance.
Discussion: This comprehensive and detailed protocol will be the first trial to compare the effectiveness of different weekly frequencies of TC in elders with CNLBP. The outcomes may provide valuable data about the choice of ideal number of sessions to further normalise the application of exercise for clinicians.
Trial registration: Chinese clinical trial registry, ChiCTR2200058190, Registered on 1 April 2022. http://www.chictr.org.cn/showproj.aspx?proj=162729.
Different approaches for the treatment of myopic choroidal neovascular: a network meta-analysis
Authors: Wu Yajun , Feng Yuliang , Yang Jiasong , Fan Hua , Yu Zitong , Xie Xiaolin , Dai Yumeng , Li Wensheng
Published: September 2022

Purpose: In order to evaluate the efficacy of intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs, photodynamic therapy (PDT), and laser treatment (LT) for anatomical and functional improvement in myopic choroidal neovascularization (mCNV) patients were evaluated in a mesh meta-analysis.
Methods: Two researchers independently searched PubMed, Cochrane Library, Web of Science, CNKI, WanFang Data, Embase, and other databases to screen RCTs and retrospective studies comparing best-corrected visual acuity (BCVA) and foveal center thickness (FCT) changes after mCNV treatment. The retrieval time limit is from the database construction to November 30, 2021. ADDIS1.16.8 and R 3.5.3 software were used to conduct mesh meta-analyses of RCTs and retrospective studies, respectively.
Results: A total of 601 eyes in 8 RCTs involving 6 treatment options: intravitreal bevacizumab (IVB), intravitreal ranibizumab (IVR), intravitreal conbercept (IVC), intravitreal aflibercept (IVA), LT, PDT, sham first followed by IVA (Sham /IVA). The results of the mesh meta-analysis showed that: in the RCTs, IVB and IVR were superior to PDT [MD=0.18, 95%CI (0.01, 0.42)] in improving BCVA of mCNV patients, and all the therapeutic effects from high to low might be intravitreal IVA, IVB, IVR, LT, Sham/IVA, and PDT; the order of FCT thickness reduction from high to low is IVA, IVR, IVB, PDT. In addition, the results of BCVA after long-term treatment in retrospective studies showed that all the therapeutic effects from high to low might be IVA, IVC, IVB /IVR, IVB, IVR, PDT, PDT with IVB /IVR; as for the order of FCT thickness reduction from high to low is IVA, IVC, IVR, IVB, PDT.
Conclusions: Anti-VEGF treatment in patients with long-term improvement in mCNV vision effect is best, using IVB or IVR alone to treat mCNV may be better than IVB or IVR combined with PDT; There was no significant difference in the improvement of visual acuity and macular edema in mCNV patients with different anti-VEGF drugs. Due to the limited number and quality of included literature, the above conclusions need to be confirmed by more large-sample and high-quality articles.
Evaluation of Calorie and Protein Intakes and Clinical Outcomes in Critically Ill Patients: Cross- sectional study
Authors: Badpeyma Mohaddeseh , Malekahmadi Mahsa , Sedaghat Alireza , Ostad Andisheh Norouzian , Khadem-Rezaiyan Majid , Pahlavani Naseh , Salami Fatemeh Ebrahimbay , Moghaddam Ahmad Bagheri
Published: September 2022

Background:Critically ill patients admitted to the intensive care unit (ICU) are often hyper-metabolic and hyper-catabolic and at risk of malnutrition. This study aimed to evaluate the amount of energy and protein intake and its correlation with the required amount in critically ill patients.Method:Seventy patients with critical conditions who were admitted to ICU were eligible (age ≥18 years and over a 3-day stay in ICU). Basic characteristics, medical history, and laboratory test results were extracted from the patients' medical records. Anthropometric indices and APACHE II questionnaire were assessed by an expert nurse. The calorie and protein requirement of patients were considered 25 kcal/kg/day and 1.2 g/kg/day, respectively.Result:Mean age in the target population was 57.69 ± 20.81 years, and 48.6% were men. The mean actual energy intake was significantly lower than the requirement (531.27 ±365.40 vs. 1583.77 ± 329.36 Kcal/day, P˂0.001). The mean actual protein intake was significantly lower than the requirement (14.94 ±18.33 vs. 74.11 ± 17.89 gr/day respectively, P˂0.001). Patients had a growing trend in providing energy and protein over time. There is a significant reverse correlation between the age of patients and total lymphocyte count (r= -0.38, P=0.003). Also, there is a significant reverse correlation between the Glasgow coma scale and the duration of mechanical ventilation (r=-0.49, P˂0.001). The lowest average calorie and protein intake are in patients with poisoning.Conclusion:The amount of calorie and protein intake in critically ill patients is significantly less than the recommended amount, therefore, it is necessary to perform routine nutritional assessments.
Identification Modelling and fault-tolerant predictive control for industrial input nonlinear actuator system
Authors: Dong Shijian , Zhang Yuzhu , Wang Xuesong , Cheng Yuhu
Published: September 2022

Industrial control system plays an important role in process industry, chemical production and other manufacturing industries. It has important theoretical research significance and engineering application value to establish accurate models for industrial actuator system with dead-zone input nonlinearity. The structure and order of the typical system model are determined by analyzing the mechanism relationship of the system. Based on sampled data, a data-driven identification algorithm is proposed for industrial actuator system with dead-zone input nonlinearity to describe the main dynamic characteristics of the system output. The convergence property of the proposed algorithm is also analyzed. Process faults will reduce the tracking control accuracy of industrial actuator systems. An intermediate observer is used to estimate the faults. A fault-tolerant synchronous control feedback rate based on fault estimation is designed to compensate faults. The input dead zone block will weaken the feedback control performance of the input signal and reduce the control precision of the intermediate observer. According to the dead zone model, a compensator is introduced to transform the dead zone function into a linear function passing through the origin of coordinates. The transformed linear segment and the dynamic linear segment of the system constitute the generalized linear system. The model predictive control (MPC) strategy is designed to achieve robust and precise control by eliminating the effect of measurement noise. Finally, numerical simulation example and experimental test results verify the superiority and merit of the modeling method and fault-tolerant control strategy.
Genomic selection for salinity tolerance in japonica rice
Authors: Bartholomé Jérôme , Frouin Julien , Brottier Laurent , CAO Tuong-Vi , Boisnard Arnaud , Ahmadi Nourollah , Courtois Brigitte
Published: September 2022

Improving plant performance in salinity-prone conditions is a major challenge in breeding programs. Genomic selection is currently integrated into many plant breeding programs as a tool for increasing selection intensity and precision for complex traits and for reducing breeding cycle length.
A reference panel (RP) of 241 japonica accessions genotyped with 20,255 SNPs grown in control and mild salinity stress conditions was evaluated at the vegetative stage for eight morphological traits and ion mass fractions (Na and K). Weak to strong genotype-by-condition interactions were found for the traits considered. Cross-validation showed that the predictive ability of genomic prediction methods ranged from 0.25 to 0.64 for multi-environment models with morphological traits and from 0.05 to 0.40 for indices of stress response and ion mass fractions. The performances of a breeding population (BP) comprising 393 accessions were predicted with models trained on the RP. For validation of the predictive performances of the models, a subset of 41 accessions was selected from the BP and phenotyped under the same experimental conditions as the RP. The predictive abilities estimated on this subset ranged from 0.00 to 0.66 for the multi-environment models, depending on the traits, and were strongly correlated with the predictive abilities on cross-validation in the RP in salt condition (r = 0.69).
We show here that genomic selection is efficient for predicting the salt stress tolerance of breeding lines. The integration of genomic prediction into breeding strategies could increase the efficiency of breeding programs for crops to be grown in salinity-prone environments.
Knowledge of the population on the influence of diet on renal lithiasis
Authors: Ramos Christiane Ishikawa , Bronzate Rodrigo Torquato , Moreira Ana Paula Nehara
Published: September 2022

Kidney stones is a very prevalent disease, whose morbidity is associated with the recurrence of stone formation. Food plays an important role in the prevention and treatment of the disease, but this impact is still not widespread. Objective: The present study aims to evaluate the knowledge of the general population and of individuals with nephrolithiasis regarding the formation of kidney stones and the dietary measures recommended for their prevention. Methods: This is a descriptive, cross-sectional study, with a convenient sample. Data were collected using an online questionnaire containing 39 questions [sociodemographic data (8), health data (14), and dietary treatment knowledge (17)], shared on social media. Results: The questionnaire was answered by 283 participants [76.1% women; median age 34.5 (28-75.41) years], 61. 5% reporting being lithiasic. The lythiasic group had more comorbidities than the non-lythiasic one. Most of the participants (85.9%) believed that diet could prevent the formation of kidney stones, with higher frequency in the non-lythiasic group (93.6% vs lythiasics81%, p=0.003).Lithiasics in comparison with non-lythiasics presented lower frequency of correct answers for the items "increased fluid intake" (87.9% vs 95.4%, p=0.034) and "regular consumption of fruits, vegetables and vegetables" (47.7% vs 60.6%, p=0.035), the factors that decrease stone formation; and "milk chocolate being the most indicated for individuals with oxalate-based stones" (5.7% vs 13.8%, p=0.021). However, lithiasics had a higher frequency of correct answers about "low calcium intake increases stone formation" (29.9% vs non-lithiasics: 24.8%, p=0.018). Conclusion: the present study shows that there are gaps in knowledge about dietary advice in patients with renal lithiasis, which is even more worrying about the few differences when compared to non-lithiasic individuals.
Time constant to determine PEEP levels in mechanically ventilated COVID-19 ARDS: a feasibility study
Authors: Depta Filip , Euliano Neil R. , Zdravkovic Marko , Török Pavol , Gentile Michael
Published: September 2022

Background: We hypothesized that the measured expiratory time constant (TauE) could be a bedside parameter for the evaluation of positive end-expiratory pressure (PEEP) settings in mechanically ventilated COVID-19 patients during pressure-controlled ventilation (PCV).
Methods: A prospective study was conducted including consecutively admitted adults (n = 16) with COVID-19-related ARDS requiring mechanical ventilation. A PEEP titration using PCV with a fixed driving pressure of 14 cmH2O was performed and TauE recorded at each PEEP level (0 to 18 cmH2O) in prone (n = 29) or supine (n = 24) positions. The PEEP setting with the highest TauE (TauEMAX) was considered to represent the best tradeoff between recruitment and overdistention.
Results: Two groups of patterns were observed in the TauE plots: recruitable (R) (75%) and nonrecruitable (NR) (25%). In the R group, the optimal PEEP and PEEP ranges were 8±3 cmH2O and 6-10 cmH2O for the prone position and 9±3 cmH2O and 7-12 cmH2O for the supine position. In the NR group, the optimal PEEP and PEEP ranges were 4±4 cmH2O and 1-8 cmH2O for the prone position and 5±3 cmH2O and 1-7 cmH2O for the supine position, respectively. The R group showed significantly higher optimal PEEP (p<0.004) and PEEP ranges (p<0.001) than the NR group. Forty-five percent of measurements resulted in the most optimal PEEP being significantly different between the positions (p < 0.01).
Conclusions: TauE may be a novel method to assess PEEP levels. There was wide variation in patient responses to PEEP, which indicates the need for personalized evaluation.
The Relationship Between Increased Intervertebral Disc Height (IDH) and Development of Postoperative Dysphagia After Single-level Anterior Cervical Discectomy and Fusion (ACDF) — A retrospective Study of 217 Cases
Authors: Gao Zhiqiang , Wang Qiang , Wang Bijun , Guo Kai , Lu Jiawei , Wu Desheng , Huang Yufeng
Published: September 2022

Background: One goal of the ACDF is to restore the loss of intervertebral disc height (IDH) results from the degenerative process. However, the effect of IDH on postoperative dysphagia after ACDF remain unclear.
Methods: 217 consecutive patients after single-level ACDF were enrolled. Based on the results of a one-year telephone follow-up, the patients were divided into dysphagia group and non-dysphagia group. Radiologically, IDH, spinous process distance (SP) of the operated segment and C2-7 angle (C2-7A) were measured preoperatively and postoperatively. The relationship between changes of above radiological parameters and the development of dysphagia was analyzed.
Results: 63 cases exhibited postoperative dysphagia. The mean changes in IDH, SP and C2-7A were 2.84 mm, -1.54 mm, and 4.82 degrees, respectively. Change of IDH (P=0.001) and change of C2-7A (P=0.000) showed significant differences between dysphagia and non-dysphagia patients. Increased IDH and increased C2-7A (P=0.037 and 0.003, respectively) significantly and independently influenced the incidence of postoperative dysphagia. When change of IDH ≥ 3 mm, the chance of developing postoperative dysphagia of this patient is significantly greater. No significant relationship was observed between change of spinous process distance (SP) and the incidence of dysphagia.
Conclusion: The change of IDH could be regarded as a predictive factor for postoperative dysphagia after single-level ACDF.
FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division
Authors: Jin Xiaofeng , Zhang Hui , Wang Jie , Li Jinyun , Zhong Yeling , Cao Xinyi , Jin Jiabei , Lin Yan , Ma Xinyi , Yu Zongdong , Ni Xiaoqi , Li Xinming , Lin Man , He Jian , Luo Xia , Gu Chaoyu , Yang Weili , Ye Meng
Published: September 2022

Endometrial carcinoma (ECa) is the most common malignant gynecological cancer, with an increased incidence and fatality rate worldwide. Hyperactive INF2-associated mitochondrial division is involved in the occurrence and development of various tumors, including ECa, although the molecular mechanism is unclear. In this study, we confirmed that FBXO7, an E3 ubiquitin ligase, inhibits INF2-associated mitochondrial division through ubiquitination and degradation of INF2 and acts as a tumor suppressor in ECa. Moreover, we found that ECa-associated FBXO7 mutants were defective in the degradation of INF2, promoting ECa cell proliferation and migration through hyperactive INF2-associated mitochondrial division. In addition, our data support the possibility of using the mitochondrial division inhibitor Mdivi-1 in the treatment of FBXO7-mutated ECa. Our study revealed a novel pathogenesis of ECa and may provide a new treatment strategy for ECa patients with FBXO7 mutations.
Semipres: an Integrated Deep Learning Method of Sequence and 3d Object Detection Models for Host-microbe Interactions by Identification of Protein-protein Contact Residues
Authors: Lim Hansaim , Keskin Ozlem , Nussinov Ruth , Gursoy Attila
Published: September 2022

Background
Interface mimicry is an important strategy for microbes to efficiently interfere with host protein-protein interactions to maximize their survival and spread. With interface mimicry, microbial proteins with surface residues that can structurally mimic the known interactor of host proteins have a potential to interact with the host. Computationally predicting such interactions is critical to understand the mechanisms of microbe-induced diseases and drug discovery. Computational methods that do not use protein 3D structures (e.g., sequence-only methods) are generally less accurate, and those that require 3D structures are limited by the structural coverage and cannot utilize the abundant information available from sequences.
Results
Here we present a new deep learning method that integrates ALBERT, a natural language processing model with PointNet, a 3D object identification model. The ALBERT component learns from the vast amount of available sequence data, and the PointNet component makes it available to predict the contact residues. We show that a natural language processing model can combine with PointNet and be applied to the interface mimicry concept for predicting protein-protein interactions. On a benchmark, the method outperformed a graph convolutional neural network model with a similar purpose.
Conclusions
Our deep learning method for protein-protein interaction prediction is the first method that integrates sequence-based and structure-based deep learning to predict interface mimicry. Our analyses indicate that it performs better for heterodimer predictions than homodimers. This integration is a promising idea, however the method can further be optimized for better predictive performance.
Prevalence, Trends, and Characteristics of Nonalcoholic Fatty Liver Disease among the US Population Aged 12–79 Years
Authors: Shen Tsung-Hua , Wu Chung-Hsuen , Lee Yuan-Wen , Chang Chun-Chao
Published: September 2022

Background & Aims: Clinical observation revealed an increase in nonalcoholic fatty liver disease (NAFLD) prevalence among adults and adolescents and young adults (AYA). However, its prevalence trend in specific subgroups and its characteristics are unclear.
Approach & Results: This cross-sectional study included adults and AYA aged 20–79 and 12–19 years, respectively, from the National Health and Nutrition Examination Survey from 1999 to 2018. NAFLD was defined as US Fatty Liver Index ≥ 30 in adults and alanine amino transaminase elevation and obesity in AYA. Joinpoint and logistic regression were used to evaluate the NAFLD prevalence trend and its associated characteristics. NAFLD was diagnosed in 17,156,892 of 51,109,914 (33.6%) adults and 1,705,586 of 29,278,666 AYA (5.8%). During the study period, NAFLD prevalence significantly increased from 30.8–37.7% (P < 0.01) in adults and in subgroups of female participants, individuals aged 20–45 and 61–79 years, and non-Hispanic white individuals. Conversely, NAFLD prevalence did not significantly change in AYA (from 5.1–5.2%, P = 0.139), except in the subgroup of Mexican Americans (from 8.2–10.8%, P = 0.01). Among adults, high NAFLD prevalence was associated with male sex, Mexican American ethnicity, age > 50 years, being unmarried, poverty income ratio < 130, poor or fair health condition, obesity or overweight, and chronic conditions. Among AYA, high NAFLD prevalence was associated with male sex, poverty income ratio < 130, and education.
Conclusions: Accordingly, we concluded that health care providers should prevent and treat conditions associated with NAFLD by raising awareness of the increasing trend of NAFLD.
Early transthoracic echocardiography and long-term mortality in moderate to severe ARDS: analysis of the MIMIC-III database
Authors: Liu Qiuyu , Tang Yingkui , Tao Wu , Tang Ze , Wang Hongjin , Nie Shiyu , Wang Nian
Published: September 2022

Background
While the use of transthoracic echocardiography (TTE) in the intensive care unit (ICU) is rapidly expanding, the contribution of early-TTE to altering patient outcomes among ICU patients with acute respiratory distress syndrome (ARDS) has not been examined. This study aimed to analyze the effect of early TTE on long-term mortality in patients with moderate to severe ARDS in ICU.
Methods
We obtain 3425 moderate-to-severe ARDS patients who had or had not received early TTE from MIMIC-III database, after imputing missing values through the random forest model, to guarantee that our findings were robust, we utilized a variety of statistical methods including propensity score matching (PSM), inverse probability of treatment weight (IPTW), covariate balancing propensity score (CBPS), multivariable regress, doubly robust estimation to balance 39 covariates and evaluate the effect of early TTE on long-term mortality. We used t-tests for continuous outcomes and χ2 tests for categorical outcomes.
Results
Early-TTE group’s 90-day mortality exhibited a significant improvement comparing to non-early-TTE group (odds ratio = 0.77 95% CI 0.63–0.94, p-value = 0.009)), which reveal its beneficial effect. On the third day of ICU admission and throughout the hospital stay, the early-TTE group had considerably decreased net-input (845.37 vs. 1156.78 mL and 8353.90 vs. 4877.25 mL). The serum creatinine reduction exhibited a significant difference between these two groups and revealed the early-TTE’s beneficial effect on the kidney (0.57 vs. 0.84, p-value = 0.003).
Conclusions
Early application of TTE is beneficial to improving the long-term mortality of patients with moderate to severe ARDS.
Association Between the MTHFR 677C/T Polymorphism and Susceptibility to Psoriasis: An Updated Meta‑Analysis
Authors: Qi Junhua , Zhang Yu , Zhang Lvya , Nie Gang
Published: September 2022

The correlations between psoriasis and methylenetetrahydrofolate reductase (MTHFR) 677C/T polymorphism have been examined in a number of studies. However, the findings are still ambiguous. The present meta-analysis was conducted to comprehensively evaluate this issue. Eligible studies were searched from EMBASE, PubMed, Web of Science, Wan Fang Database and Chinese National Knowledge Infrastructure (CNKI) up to 30 November 2021. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to estimate the effects of MTHFR 677C/T polymorphism on psoriasis risk under different genetic models. A total of 11 relevant case-control studies were included in our meta-analysis, involving 2010 psoriasis cases and 1881 healthy controls. Pooled analysis suggested that MTHFR 677C/T polymorphism was associated with increased psoriasis risk under the recessive model (TT vs TC + CC, OR = 1.69, 95%CI = 1.09–2.61, P = 0.020). Stratification by ethnicity indicated that MTHFR 677C/T polymorphism was associated with increased psoriasis risk in Asian under the recessive model (TT vs TC + CC, OR = 1.64, 95%CI = 1.01–2.67, P = 0.046)and in European under the allelic model (T vs C, OR = 2.57, 95% CI = 1.02–6.48, P = 0.046). In conclusion, MTHFR 677C/T polymorphism might be associated with increased psoriasis risk. TT genotype might increase psoriasis risk in Asian. Allele T might increase psoriasis risk in European.