bluuebunny/crossref_metadata_2025 huggingface dataset:
Issues in reproductive health in chromosome translocation carriers
Authors: Shilenkova Yulia V. , Pendina Anna A. , Fedorova Elena M. , Efimova Olga A. , Chiryaeva Olga G. , Petrova Lubov' I. , Dudkina Vera S. , Tikhonov Andrei V. , Gzgzyan Alexander M. , Bespalova Olesya N. , Kogan Igor Yu.
Published: December 2022

BACKGROUND: It is common a wide range of reproductive disorders in couples with structural chromosome aberration in one of the partners, such as infertility, miscarriage, unsuccessful assisted reproductive technologies attempts. In this regard, predicting the reproductive outcome in a particular couple is an extremely difficult task. To solve it, it is necessary to consider the influence of many factors, including the type of chromosome translocation and the carriers sex.
AIM: To evaluate the structure of reproductive disorders in couples where one of the partners was a chromosome translocation carrier, depending on its type: Robertsonian or reciprocal, and carriers sex.
MATERIALS AND METHODS: In this retrospective cohort study, we analyzed the clinical and anamnestic data of 100 couples where one of the partners was a chromosome translocation carrier. Couples applied to fertility centers between March 2009 and May 2019. To assess the effect of the type of chromosomal translocation and carriers sex, we provided intergroup comparisons.
RESULTS: Comparative analysis of somatic pathology and chronic gynecological diseases didnt reveal significant differences between groups of female patients (Fischers exact test, p 0,05). An intergroup comparison of reproductive outcomes in couples divided by the type of chromosome translocation: reciprocal or Robertsonian, and the carriers sex, detected significant differences. Primary infertility was significantly more often detected in couples with a male translocation carrier, secondary with a female carrier (Fishers exact test, p = 0,01). Pregnancy significantly more frequent occurred and, it was also significantly more often spontaneously interrupted in couples with a female carrying of reciprocal or Robertson translocation (2 = 13,29, df = 3, p = 0,004). Thus, a female carrying a chromosomal translocation is characterized by a greater risk of miscarriage.
CONCLUSIONS: The chromosome translocation type and the carriers sex have a differential effect on the nature of reproductive disorders. Female carrying a chromosomal translocation increases the likelihood of both pregnancy and its spontaneous termination. In contrast, in couples with a male translocation carrier, the probability of both pregnancy and miscarriage is lower. Thus, the type of translocation and the carriers sex determine the individual risks of reproductive disorders, including infertility and miscarriage, which should be considered in the planning, choosing the method of onset and management of pregnancy.
Microbiological safety of the Dr. Arabin cervical pessary in pregnant women with short cervix
Authors: Sargsyan Gabriel S. , Bespalova Olesya N. , Savicheva Alevtina M. , Khusnutdinova Tatyana A. , Budilovskaya Olga V. , Krysanova Anna A. , Shalepo Kira V.
Published: December 2022

BACKGROUND: The insertion of a cervical pessary is a method for treating short cervix and preventing preterm birth. The study of the vaginal microbiota composition and the need for its routine correction after the pessary insertion remain to be investigated. To date, there are no works devoted to the assessment of changes in vaginal microbiocenosis after the cervical pessary insertion.
AIM: The aim of this study was to assess the microbiological safety of the Dr. Arabin cervical pessary in pregnant women with short cervix.
MATERIALS AND METHODS: This prospective study included 22 pregnant women with singleton or multiple pregnancies with short cervix (25 L.J. Salomon scale) and threatened miscarriage in the second and third trimesters who received the Dr. Arabin cervical pessary. The obtained clinical materials included the secretion of the posterolateral vaginal fornix. We used the Femoflor 16 test (NPO DNA-Technology Ltd., Moscow, Russia) as a method of molecular biological analysis. In addition, the patients independently controlled the pH of the vaginal contents using the pH-balance express test. Vaginal microbiocenosis was assessed in a dynamic manner: before the cervical pessary insertion, then every two to four weeks after it, and on the day the pessary was removed. In all 22 pregnant women, clinical material was obtained twice: before the cervical pessary was inserted and when it was removed; in 15 women (68.18%) three times, and in nine pregnant women (40.91%) four times.
RESULTS: The analysis of vaginal microbiocenosis showed no significant changes in vaginal microbiocenosis in the examined pregnant women before and after the insertion of the cervical pessary (p 0.05). The concentration of lactobacilli remained high (in the range of 107 lg DNA copies/ml) during the entire observation period. The numbers of facultative and obligate anaerobic bacteria, as well as yeast-like fungi of the Candida genus, Ureaplasma spp., and Mycoplasma hominis were within the physiological levels. No pathogenic microorganisms such as Mycoplasma genitalium were detected in any patient. After the cervical pessary insertion against the background of normocenosis, 72.73% of pregnant women noted an increase in the amount of light and odorless discharge from their genital tract. However, we found no changes in the vaginal microbiota composition.
CONCLUSIONS: The insertion of the Dr. Arabin cervical pessary under conditions of vaginal normocenosis is a microbiologically safe way to correct short cervix and prevent preterm birth, and does not disrupt the vaginal microflora in pregnant women before delivery.
New possibilities of differential diagnosis of uterine fibroids and adenomyosis nodes based on a complex ultrasound assessment
Authors: Shalina Maria A. , Nagorneva Stanislava V. , Yarmolinskaya Maria I.
Published: December 2022

BACKGROUND: Ultrasound is widely used in routine practice to diagnose various forms of adenomyosis and uterine fibroids. However, due to the lack of unified criteria, hypo- or overdiagnosis of internal endometriosis is possible. Moreover, there are a number of difficulties in the differential diagnosis of nodular adenomyosis and uterine fibroids.
AIM: The aim of this study was to develop a complex technique for the differential diagnosis of uterine fibroids and adenomyosis nodes.
MATERIALS AND METHODS: We applied a complex ultrasound technique with a detailed and consistent application of the following tools 3D reconstruction, elastography, color Doppler, 3D power Doppler (glass body mode). The study was conducted in 124 patients of reproductive age with subsequent intraoperative and histological confirmation of the diagnosis.
RESULTS: After the proposed ultrasound technique, uterine fibroids were diagnosed in 112 (90.3%) patients, of whom 85 (75.9%) patients had uterine fibroids combined with a diffuse form of internal endometriosis. Nodular adenomyosis was diagnosed in 12 (9.7%) patients. The additional examination and surgical treatment showed that the preliminary diagnosis of uterine fibroids was confirmed in 110 out of 112 women, and in two other cases, nodular adenomyosis was diagnosed. Eleven (91.7%) out of 12 patients were diagnosed correctly with nodular adenomyosis by the complex ultrasound examination, while in one case the preliminary diagnosis proved to be incorrect, with a conglomerate of three myomatous nodes detected as a result of surgical treatment. Thus, based on the technique we developed, the correct diagnosis was made in 121 (97.6%) patients. Misdiagnosis in three cases was associated with a history of a long-term medical treatment of adenomyosis and therefore Doppler and elastography results had lower sensitivity.
CONCLUSIONS: The development of the described complex ultrasound technique allows for accurately diagnosing the form of adenomyosis, identifying early forms of the disease and differentiating adenomyosis nodes from myomatous nodes, which is necessary for the correct diagnosis, the right choice of the management tactics and the necessary treatment.
Immune interface of patients with reproductive loss in the North-West region of the Russian Federation
Authors: Shengeliia Margarita O. , Bespalova Olesya N. , Zhernakova Tatyana S. , Zagaynova Valeria A. , Agnayeva Alana O. , Pachuliia Olga V. , Chepanov Sergey V. , Domanskaya Maria A. , Selkov Sergey A. , Kogan Igor Yu.
Published: December 2022

BACKGROUND: Currently, more than a hundred immunological biomarkers are known that are important for fertilization, implantation and placentation.
AIM: The aim of this study was to assess the immunological profile for the main allo- and autoantibodies in women with reproductive loss and infertility in the North-West region of the Russian Federation.
MATERIALS AND METHODS: This prospective cohort study was conducted at the stage of pregnancy planning in 325 women with reproductive disorders (spontaneous miscarriages, missed abortions, infertility, IVF failures) on the premises of the D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductive Medicine (St. Petersburg, Russia) from 2015 to 2022. The study assessed the immune interface of women with a history of reproductive disorders and matching loci of the HLA class II system (DQA1, DQB1, DRB1) among 100 married couples.
RESULTS: In couples with reproductive disorders, coincidences of HLA class II allele (DQA1, DQB1, DRB1) loci were diagnosed in 14% (at 2 loci), 31% (at 3 loci), 14% (at 4 loci), 3% (at 5 loci) and 10% (at 6 loci) of couples. In 34.4% of women, we found an elevated number of spontaneously activated NK cells (CD107a). As many as 31.15% of women had a high level of antibodies to human chorionic gonadotropin. We found that 22.34% of women were carriers of at least one criteria antiphospholipid antibody, and 3.16% of women of two antiphospholipid antibodies. The diagnosis of antiphospholipid syndrome was not established in any patient. Non-criteria antiphospholipid antibodies were found in 6.15% of women. In 12.2% of women, we diagnosed a high level of antibodies to thyroperoxidase, while the average antibody value was 30.76 IU/ml. Only one patient had a high level of antisperm antibodies in the blood serum.
CONCLUSIONS: In 59% of patients with a history of reproductive disorders, we identified some features of the immunological profile, which can lead to this pathology. Thus, 32% of women had a deviation in one immunological parameter, while 20% of patients had it in two parameters, and 7% in three or more parameters.
Efficiency of intravenous therapy with Intralipid fat emulsion in patients with early reproductive loss
Authors: Bespalova Olesya N. , Zhernakova Tatyana S. , Selkov Sergey A. , Chepanov Sergey V.
Published: December 2022

BACKGROUND: Immune mechanisms play a leading role in the pathogenesis of early reproductive loss. Modern methods of regulating disorders of immune homeostasis to overcome infertility and recurrent miscarriage include immune-efferent therapies such as immunocytotherapy, plasmapheresis, and intravenous administration of immunoglobulins and fat emulsions. Intralipid is the gold standard of the first generation parenteral fat emulsion that reduces the cytotoxicity of NK cells. In the literature, there are opposite data on the effectiveness of Intralipid fat emulsion in repeated implantation failure. This may be due to indications for its appointment and the choice of criteria for evaluating the effectiveness of this therapy.
AIM: The aim of this study was to evaluate the effect of Intralipid therapy on the onset of pregnancy in patients with a history of early reproductive loss.
MATERIALS AND METHODS: This prospective cohort study was conducted in Saint Petersburg, Russia in 20182021 and included 97 patients with a history of early reproductive loss (recurrent pregnancy loss or repeated In Vitro Fertilization failures). Patients were randomized into two study groups. The first group consisted of 41 women with Intralipid therapy, and the second group comprised 56 women without this therapy. Patients of the first group received 200 ml of Intralipid 20% (intravenous fat emulsion) once a month for three consecutive months before pregnancy. Inclusion criteria were ages 18 to 40 years, two cases of reproductive failure (pregnancy loss up to 12 weeks and / or unsuccessful In Vitro Fertilization attempts), and normal spouse karyotypes. Exclusion criteria were miscarriage due to fetal chromosomal abnormalities diagnosed by curettage and histopathological examination of products of conception from miscarriages, anatomical anomalies in the development of the genital apparatus, abnormal spouse karyotypes, and soy protein allergy. We evaluated anamnesis data and immunological parameters (functional activity of NK cells in peripheral blood before and after treatment). The efficacy of therapy was judged by the onset of pregnancy.
RESULTS: The Mann Whitney U-test showed the difference in the levels of NKT cells before and after treatment with fat emulsions (p = 0.0076), this parameter decreasing 1.846 times compared to control. Clinical pregnancy in patients treated with Intralipid occurred twice as often compared to patients who did not receive fat emulsion therapy: 59.3% (n = 19) vs. 27.6% (n = 13), respectively (p = 0.0048).
CONCLUSIONS: Intralipid fat emulsion increases pregnancy rates by decreasing NKT cells in women with early reproductive loss.
Morphological and molecular features of recurrent endometrioid ovarian cysts
Authors: Petrovskaia Nikol N. , Pechenikova Victoria A. , Chashchina Darya M.
Published: December 2022

BACKGROUND: One of the clinical course features of ovarian endometriosis is its recurrent nature, which leads to repeated operations and increased damage to the ovarian follicular apparatus.
AIM: The aim of this study was to evaluate morphological and molecular features of recurrent endometrioid ovarian cysts in patients of reproductive age.
MATERIALS AND METHODS: Morphological and immunohistochemical studies of the surgical material of 196 observations of endometrioid ovarian cysts were performed 23 observations of the first surgical intervention with further diagnosed relapse, 22 observations of repeated surgery and 151 observations of a relapse-free course of endometriosis. Monoclonal mouse antibodies to CD68, transforming growth factor -1, CD34, and -smooth muscle actin were used.
RESULTS: CD68 (macrophage) expression was detected in lympho-macrophage infiltrates of the cytogenic stroma and endometrioid cyst capsule. Significantly greater values of the expression were obtained in recurrent endometrioid cysts in the surgical material of both the first (cytogenic stroma 31 [8; 53]%, capsule 23 [3; 42]%) and second operation (23 [12; 36] and 9 [5; 20]%, respectively) compared to the relapse-free course of the disease (8 [6; 9] and 2 [0; 4]%, respectively). The transforming growth factor -1 expression area in the endometrioid cyst capsule was significantly higher in the surgical material of both the first (22.8 [21.6; 24.8]%) and second operation (31.2 [30.5; 32.2]%) with recurrent endometriosis compared to cases with no relapse (12.7 [11.2; 13.9]%). But in the cytogenic stroma was it only detected in cases of repeated surgical endometrioid cyst treatment (18.7 [18.0; 19.7]%). The positive -smooth muscle actin expression area was higher in the surgical material of the second operation with recurrent endometriosis in both the cytogenic stroma (68.3 [66.3; 69.6]%) and endometrioma capsule (82.5 [80.5; 83.8]%). A large area of CD34 expression was also detected in the recurrent course of ovarian endometriosis in the surgical material of both the first (cytogenic stroma 34.8 [33.4; 35.8]%, capsule 52.6 [50.4; 55.0]%) and second operation (51.3 [49.0; 53.3] and 48.7 [46.7; 49.8]%, respectively).
CONCLUSIONS: The recurrent course of ovarian endometriosis is characterized by more pronounced inflammation, angiogenesis, myofibroblast proliferation, and fibrogenesis, which indicates the importance of these pathological processes in the chronicity of the disease. Further study of the role of macrophages and the cascade of regenerative and reparative processes that they trigger is important for understanding the pathogenesis of endometriosis and searching for diagnostic markers of its recurrent course.
Risk factors for recurrence of endometrioid ovarian cysts after combined treatment
Authors: Petrovskaia Nikol N. , Pechenikova Victoria A.
Published: December 2022

BACKGROUND: The main method of endometrioid ovarian cyst treatment is considered surgery with further hormone therapy. However, the recurrence rate of endometriomas, even 57 years after combined treatment, can reach 50%.
AIM: The aim of this study was to identify risk factors for recurrence of endometrioid ovarian cysts among women of reproductive age after combined treatment.
MATERIALS AND METHODS: This study included 196 women operated on for ovarian endometriosis. We carried out a comparative analysis of the data between the study groups: the main group comprised 45 patients with a relapse of the disease; the comparison group consisted of 151 women without a relapse. Hematoxylin-eosin staining was used for morphological examination of the surgical material, and monoclonal mouse antibodies to Ki-67 and bcl-2 (DAKO, Denmark) were used for immunohistochemical examination. The construction of a statistical model for predicting the recurrence of ovarian endometriosis among women of reproductive age was carried out using multivariate binary logistic regression analysis in reverse stepwise mode. The influence of the independent variable on the likelihood of recurrence was determined using the odds ratio and its 95% confidence interval, with the sensitivity, specificity and diagnostic accuracy evaluated.
RESULTS: A set of predictors has been identified that provides the greatest contribution to recurrence of ovarian endometriosis. Immunohistochemistry study showed that the level of Ki-67 protein was higher in the group with relapsed endometriomas compared to the non-recurrent course: in the epithelial lining of the cyst, 9.08 2.60 and 2.06 1.16%, respectively (p = 0.043); in the cytogenic stroma, 11.67 4.10 and 9.81 3.40%, respectively (p = 0.48). Bcl-2 expression was reduced in the epithelial lining of the cyst capsule in the main group in comparison with the material where there was no recurrence: 0.653 0.043 and 0.961 0.056%, respectively (p = 0.31).
CONCLUSIONS: Of significance in predicting the risk of recurrence of ovarian endometriosis is a combination of four signs in one patient: primary infertility; pelvic organ surgery in history, unrelated to endometriosis; elevated levels of CA-125 oncoprotein and proliferative changes in cytogenic stroma cells, as well as increased expression of the Ki-67 antigen in the epithelial lining of the endometrioid cyst.
Morphological changes in fetal organs and tissues in intrauterine death
Authors: Ziganshin Aydar M. , Mulyukov Ayrat  R. , Mudrov Viktor A. , Nurgaliyeva Regina R. , Zaynullina Yulia  S.
Published: December 2022

This article presents a literature review of post-mortem changes in the organs and tissues of the fetus in intrauterine death. The visual and morphological changes that can serve to determine the time of post-mortem changes in organs and tissues at various stages of pregnancy are covered. A detailed study of post-mortem changes in the fetus will help avoid medical errors and unjustified criminal prosecutions, provide an opportunity for an objective assessment of the consequences and causes of intrauterine fetal death, eliminate discrepancies in clinical and pathoanatomic diagnoses, and increase the accuracy of diagnosis and the quality of knowledge. Сomprehension of the key principles for assessing morphological changes in fetal organs and tissues in intrauterine death will allow for developing screening programs to identify relevant risk factors, which, in the future, will reduce perinatal mortality rates.
Modern methods of treatment of benign diseases of the cervix
Authors: Politova Alla  K. , Kolokoltseva Irina N. , Dudorova Svetlana  V.
Published: December 2022

This review article presents a comparative assessment of various types of energies used in the surgical treatment of cervical pathology, with their positive and negative sides. The mechanisms of action of the damaging agent, indications and contraindications, as well as results of treatment of cervical diseases and follow-up complications are presented. Attention is drawn to current promising areas in the treatment of cervix disorders. In particular, the article reviews the modern method of treatment using ultrasonic ablation, presents an idea of the methodology for conducting high-intensity focused ultrasound therapy, and discusses the possibility of conducting non-invasive this therapy. The article displays the world and domestic literature data.
Cold storage systems: present and future applications (a view from the Middle East region)
Authors: Menin Boris M.
Published: December 2022

The aim of this article is to review the existing types of cold storage systems (СSS) based on known technologies and recommendations for their improvement. The article combines research, thermodynamic analysis, economic aspects and comparison of the quality of known СSS designs. The article is of interest for government officials, manufacturers, engineers, inventors and developers to determine the advantages and disadvantages of existing СSSs. The reasons constraining the use of СSS in Israel are given. Taking into account modern foreign experience in developing cold low-temperature energy tank designs and achievements of the ice-slurry production technology of pumped ice slurries, the CSS is proposed, a software is developed and technical and economic analysis of its operation is carried out.
Development of Air Conditioning Systems
Authors: Babakin Boris S. , Belozerov Georgiy A. , Suchkov Alexandr N. , Babakin Sergey  B.
Published: December 2022

This paper presents information on the global production and energy consumption of climate equipment. Information is provided on refrigerants used in air conditioning systems, in particular about R22, which was practically abandoned by many countries in the early 2000s, however, in 2018, about half of air conditioners owned by the population worked on R22. According to a number of estimates, 600 to 800 million units are operated in the world, and about 60% of air conditioners are used refrigerants of the hydrofluorocarbon (HFC) group. Many mixed refrigerants based on the hydrofluoroolefin group are considered potentially possible refrigerants to replace the refrigerants of the HFC group (e.g., R407C, R404A, and R410A). Japan and South Korea suggest using the R32 refrigerant. In India, the production of split systems using the R290 refrigerant has been organized. Various types of air conditioners and their production in the world are presented, working mainly on refrigerants of the HFC group, e.g., R407C, R404A, and R410A. The bactericidal treatment of the air environment using electroconvection and low-temperature nonequilibrium plasma is also described, with the results of processing several cultures and metal surfaces obtained by the authors.
Prospects for Creating a New Generation of Ice banks for Systems with Uneven Heat Loads
Authors: Goncharova Galina Y. , Pytchenko Victor P. , Borzov Sergey S. , Borshchev Georgiy V.
Published: December 2022

BACKGROUND: The rational application of thermal energy storages with phase transition for objects of the food industry with significantly uneven heat loads is discussed in this article. The drawbacks of existing ice banks, suppressing their spread, are analyzed. Possible methods of addressing these problems during the designing process are considered.
AIM: Development of a new generation of ice banks with a high intensity of ice melting processes and the ability to adjust the heat load.
MATERIALS AND METHODS: The brand-new discharge method based on the film flow around ice surfaces is proposed. The proposed approach allows us to optimize the heat load and provide the maintenance of the required ice water temperature. The laboratory sample of the coaxial film heat exchanger (FHE) was designed by the authors.
RESULTS: Experimental results in the operating range of the levels of supplied water temperatures 20 ℃, 40 ℃, and 60 ℃ and mass flow rates 15, 30, 45, and 60 kg/min are carried out. The experimental results confirmed that the development construction of the FHE with the film mechanism of the heat transfer provides increasing efficiency in orders of magnitude in comparison with ice banks with bulk melting. The reduced heat load with a mass flow rate of 60 kg/min and medium temperature on 60 ℃ was 220240 kW/m2, and the maximal reduced heat load of the upper layer of coil reached 1300 kW/m2. The generalization of the results showed the application prospects of film ice banks in the refrigeration systems of various industrial and agricultural objects.
Local cryotherapy investigation on the biotissue phantom
Authors: Saakyan Natalia Y. , Pushkarev Aleksandr V.
Published: December 2022

BACKGROUND: Local cryotherapy (LC) is a physiotherapeutic method for the treatment of various diseases, including musculoskeletal disorders. The physician relies on his experience and the data from the LC equipment manufacturer for the given method and exposure modes. This is not sufficient to determine the correct dosing and to understand the effect of the various treatment parameters on the biotissue to have precise control over the effects of the treatment on the biotissues. Hence, it is imperative to conduct a study of different LC methods and modes to perform effective and safe treatments. The surface temperature of the biotissue is a convenient measurable quantity to ensure efficiency and safety. Previous studies show that the target temperature is 10 2 C, with a lower limit of 0 C. If the temperature drops below 0 C, then tissue damage is possible.
AIM: Experimental comparison and identification of the most suitable modes in two methods of contactless local cryotherapy.
MATERIALS AND METHODS: An experimental installation was developed and created. A series of experiments were carried out on a model medium with thermophysical properties close to those of the biotissues. The comparison of liquid nitrogen and air cooling was performed. The temperature was measured with resistance thermometers (Pt100) on a surface and inside of a model medium.
RESULTS: When cooled by liquid nitrogen vapors from a distance of 10 and 15 cm from the surface, the accepted average target temperature of 10 C was reached in 1.8 and 4.4 min, and at a depth of 8 mm, the temperature was 26.4 and 23.7 C, respectively. When cooled with air from a distance of 10 cm from the surface with maximum and minimum flow, the target temperature was reached in 2.5 and 13.3 min, at a depth of 8 mm, the temperature was 22.9 and 16.0 C, respectively. Although air cooling from a distance of 15 cm was not possible to lower the temperature down to the target value, the less intense flow made it possible to lower the internal temperature in the model medium more strongly while having a weaker effect on the surface. This effect can potentially be positive in the treatment of musculoskeletal disorders, mainly joints.
CONCLUSIONS: Among those tested, the most suitable modes of the considered methods that meet the requirements of efficiency, safety, and convenience of practical implementation were identified. For cooling using liquid nitrogen vapors, this is a mode spraying at a distance of 15 cm with a stable technique with a possible exposure time of 4.4 to 15 minutes. For air cooling, this is a mode with a stable technique with a constant flow with the nozzle fixed relative to the surface of the model medium at a distance of 10 cm with a minimum flow rate (350 l/min) with a possible exposure time of 13.3 to 21.5 min.
Position before submission? Techniques and tactics in competitive no-gi Brazilian jiu-jitsu
Authors: Spanias Charalampos , Kirk Christopher , Øvretveit Karsten
Published: December 2022

Brazilian jiu-jitsu (BJJ) is a grappling-based combat sport performed either with a traditional uniform, the gi, or without, known as no-gi. Differences between the two when it comes to gripping, pace, and ruleset can affect match characteristics, which has implications for how athletes approach competition. The present study investigated time-motion and technical-tactical characteristics in matches from official no-gi submission-only BJJ tournaments. The analysis included 26 regional and 26 international athletes from the light-feather to super-heavy weight class. Match characteristics did not differ between competition levels, style (guard or pass player), or weight (p > 0.05). The duration of positional dominance was similar between competition levels and styles (p > 0.05), but significantly different between winners and losers (p < 0.05; effect size (ES) = 0.39). Positional dominance also correlated with upper-body submissions (r = 0.50; p < 0.05). Interestingly, positional dominance appeared inconsequential in matches determined by lower-body submissions. In fact, athletes winning by lower-body submissions, in most cases a heel hook, exerted no positional control prior to their victory. The high- to low-intensity ratio was 1:2 and 1:1, for regional and international athletes, respectively. The standing to ground time ratio was 1:2 for both groups. In addition to the novel competition characteristics of competitive no-gi BJJ, these findings indicate that there are strategical discrepancies that precede distinctly different submission holds.
Research Trends on Digital Games and Gamification in Nursing Education
Authors: MEŞE Sevinç , MEŞE Can
Published: December 2022

This study aimed to examine the trends of digital games and gamification in nursing education. The document analysis method was carried out by adapting the PRISMA for the bibliometric analysis. 20 articles published on digital games and gamification in nursing education were analyzed. Bibliometric analysis of the metadata of the articles was performed with the Biblioshiny. It is noteworthy that the articles published on digital games and gamification in nursing education have been published mainly in recent years with collaborative work. In the articles, quantitative, qualitative, and mixed design research methods were carried out in different studies. The most related words analysis in the summary section of the publications shows that students, game, and nursing are the most related words. We can conclude that game-based learning and gamification are effective in students' active participation in the course, increasing their satisfaction levels, providing motivation, and teaching skills in nursing education.
Zekâ Oyunlarının 6. Sınıf Öğrencilerinin Yaratıcı Düşünme Becerilerine Etkileri
Authors: TERZİ Havva , KÜÇÜK-DEMİR Betül
Published: December 2022

Bu araştırmanın amacı ortaokul 6. sınıf düzeyinde uygulanan zekâ oyunlarının öğrencilerin yaratıcı düşünme becerilerine etkisini incelemektir. Araştırma 2017-2018 eğitim öğretim yılı güz yarıyılında bir devlet okulunda 6. sınıf düzeyinde ve 2 farklı şubede öğrenim gören toplam 70 öğrenci ile sürdürülmüştür. Öğrencilere 16 hafta boyunca 32 adet akıl ve zekâ oyunu eğitimi verilmiş ve zekâ oyunlarının öğrencilerin yaratıcı düşünme becerilerine etkileri araştırılmıştır. Çalışmada ön test-son test kontrol gruplu yarı deneysel yöntem kullanılmıştır. Veri toplama aracı olarak; Torrance Yaratıcı Düşünme Testi (TYDT) Sözel-Şekilsel Form-A kullanılmıştır. Verilerin analizi için SPSS 25.0 paket programı kullanılmıştır. t-testinin varsayımları test edildikten sonra normal dağılıma sahip kontrol ve deney gruplarının ön testlerinin ve son testlerinin analizi için eşleştirilmiş gruplar t-testi ve bağımsız gruplar t-testi kullanılmıştır. Araştırma sonunda elde edilen bulgulara göre son test puanları arasında deney grubu lehine anlamlı bir farklılık bulunmuştur.
Cambios en la anticoncepción post intervención de un proyecto de información, educación y capacitación sin letras (IEC) en zonas rurales de la Selva Peruana
Authors:   Universidad César Vallejo, Alzamora de los Godos Urcia Luis , Calderón-Saldaña Jully ,   Universidad Nacional Federico Villarreal, Aspilcueta-Gho Daniel ,   Ministerio de Salud
Published: December 2022

Objetivos: Determinar la variación de la fecundidad y el uso de métodos anticonceptivos en una población intervenida por el proyecto promoción y capacitación sin letras en salud reproductiva con perspectiva de género. Diseño: Estudio de Impacto. Lugar: Zonas nativas de la selva peruana, Pebas, Yanashi, Pucaurquillo y Santo Tomás. Institución: Inppares. Participantes: usuarias de los servicios de salud reproductiva de los establecimientos de salud, analfabetas o semianalfabetas (20 y 35 años). Intervenciones. 3 años de intervención con estrategias IEC de Inppares en toda la zona. Procedimientos: Entrevista personal. Material y Métodos: Estudio por encuesta. Análisis estadístico. Tablas de contingencia y gráfico de barras pre y pos-intervención. Resultados: El empleo de métodos anticonceptivos fue del 76 por ciento de las usuarias, el sector de Pucaurquillo es el de mayor prevalencia de uso de métodos (92,9%), y Santo Tomás (52,9 %). El 76 por ciento de las usuarias de los cuatro sectores de estudio emplean algún método, antes lo hacían solamente el 65. Contrastando los datos finales se encontró que el método más empleado es la Depoprovera (68,6 %), el cual se ha incrementado respecto a la línea de base (23,2%); la píldora que se incrementa ligeramente su cobertura (de 21,6 a 25%), y los otros métodos muestran cambios poco relevantes. Conclusión: Las tres cuartas partes de las entrevistadas que acuden a los servicios de salud reproductiva tienen como método más usado el Inyectable y la píldora. En cuanto a la continuidad se observó que más de la mitad de las usuarias continúan con el método anticonceptivo que empezaron, mientras que la tercera parte de las mismas cambió por otro.
Estudio comparativo del efecto inhibitorio de eritromicina, amoxicilina y sulfametoxazol – trimetoprim con el extracto acuoso del Aloe vera y su concentración inhibitoria mínima sobre Staphylococcus aureus
Authors:   Hospital Regional Lambayeque, Ñeco-Arrasco Rosita , Guevara-Flores Lis Y. , Giles-Saavedra Juan F. ,   Hospital Almanzor Aguinaga Asenjo
Published: December 2022

Objetivo: El presente trabajo se orientó a determinar el efecto inhibitorio del extracto acuoso de Aloe vera (sábila) frente a cepas de Staphylococcus aureus y comparar su actividad con la eritromicina, amoxicilina y sulfametoxazol – trimetoprim. Material y Métodos: La investigación fue de tipo prospectiva, transversal, comparativa y experimental, siendo el grupo de estudio de 10 cepas provenientes de pacientes hospitalizados. Se seleccionaron las hojas (pencas) de Aloe vera y se extrajo la pulpa que sirvió para preparar el extracto acuoso a concentraciones de 500, 800 y 1000 mg/mL, así mismo se prepararon concentraciones de 10, 20 y 30 ug/mL de los antibióticos y se enfrentaron a 10 cepas de Staphylococcus aureus aisladas de muestras clínicas (secreciones faríngeas), empleando la técnica de difusión en disco de Kirby – Bauer. Resultados: Los resultados obtenidos demostraron que el extracto acuoso de Aloe vera tiene actividad inhibitoria sobre cepas de Staphylococcus aureus las cuales fueron sensibles en un 30 % al igual que el sulfametoxazol – trimetoprim; por otro lado, los antibióticos como la eritromicina inhibió al 80 % de las cepas, seguido de la amoxicilina con 60 % de las cepas. El estudio comparativo de la actividad de los diferentes antibióticos reveló que existen diferencias en el comportamiento de las cepas frente a los antibióticos y frente a cada uno de los tratamientos utilizados, es decir que a mayor concentración mayor es el poder de inhibición de los antibióticos. Conclusión: El extracto acuoso de Aloe vera es una alternativa para el tratamiento de las infecciones por Staphylococcus aureus. Se sugiere que se realicen estudios posteriores comparativos teniendo en cuenta que las cepas sean tomadas de muestras de pacientes tanto intrahospitalarios como extrahospitalarios.
Eficacia de la colchicina en pacientes con COVID-19: una revisión narrativa
Authors:   Universidad César Vallejo, de La Roca-Collantes Alberto F. , Meregildo-Rodríguez Edinson D. ,   Universidad César Vallejo
Published: December 2022

La COVID-19 ha causado millones de muertes en todo el mundo en poco más de un año. Aunque no se conocen por completo los mecanismos implicados, diversos estudios han reportado un gran componente inflamatorio, con subsecuente liberación descontrolada de citocinas (tormenta de citocinas). La falta de terapias específicas probadas contra esta enfermedad, ha llevado a evaluar la utilidad de medicamentos seguros, de fácil acceso, y con efecto antiinflamatorio como la colchicina. Realizamos una revisión narrativa sobre la eficacia de la colchicina sobre los principales resultados clínicos adversos en pacientes con COVID-19. Incluimos 13 estudios publicados recientemente en las principales bases de datos. Concluimos que, en pacientes con COVID-19 no hospitalizados, la colchicina podría reducir la mortalidad, el riesgo de requerir hospitalización y ventilación mecánica. Mientras que, en pacientes hospitalizados con COVID-19, la colchicina no se asocia con reducción de la mortalidad, necesidad de ventilación mecánica, ni de la duración de la estancia hospitalaria. Tampoco se ha demostrado que la colchicina tenga un rol “profiláctico”.
Estrategias para mejorar la salud mental frente al confinamiento por el COVID-19 en estudiantes universitarios
Authors:   Universidad César Vallejo, Daoudi-Tume Amina A. , Perales-Díaz Juan J. M. ,   Universidad César Vallejo, Pereira-Victorio Cesar J. ,   Universidad César Vallejo
Published: December 2022

Introducción: Por la pandemia de COVID-19 se tomaron medidas de contención, entre ellas el confinamiento que afectó de forma negativa la salud mental de los universitarios, situación que obligó a establecer estrategias para mitigar el impacto psicológico. Objetivo: determinar las estrategias para mejorar la salud mental que utilizan los universitarios frente al confinamiento, conocer todas las estrategias que tienen mayor preponderancia en uso y establecer cuáles son las más utilizadas. Metodología: revisión de la literatura en las bases de datos PUBMED, SCIELO, GOOGLE SCHOLAR, obteniendo 40 artículos: 34 observacionales transversales, 4 observacionales longitudinales y 2 artículos de opinión. Resultados: se determinaron 14 estrategias de afrontamiento, agrupadas en 3 categorías: cognitivo, conductual y emocional. Conclusiones: Las estrategias con mayor preponderancia fueron las activas, a nivel cognitivo: replanteamiento positivo, conductual: afrontamiento centrado en el problema, y emocional: apoyo afectivo. Las más utilizada de las 3 categorías fue el apoyo emocional.
Detecting Mentions of Green Practices in Social Media Based on Text Classification
Authors: Glazkova Anna Valerevna , Zakharova Olga Vladimirovna , Zakharov Anton Viktorovich , Moskvina Natalya Nikolayevna , Enikeev Timur Ruslanovich , Hodyrev Arseniy Nikolaevich , Borovinskiy Vsevolod Konstantinovich , Pupysheva Irina Nikolayevna
Published: December 2022

The paper is devoted to the task of searching for mentions of green practices in social media texts. The relevance of this task is dictated by the need to expand existing knowledge about the use of green practices in society and the spread of existing green practices. This paper uses a text corpus consisting of the texts published on the environmental communities of the VKontakte social network. The corpus is equipped with an expert markup of the mention of nine types of green practices. As part of this work, a semi-automatic approach is proposed to the collection of additional texts to reduce the class imbalance in the corpus. The approach includes the following steps: detecting the most frequent words for each practice type; automatic collecting texts in social media that contain the detected frequent words; expert verification and filtering of collected texts. The four machine learning models are compared to find the mentions of green practices on the two variants of the corpus: original and augmented using the proposed approach. Among the listed models, the highest averaged F1-score (81.32%) was achieved by Conversational RuBERT fine-tuned on the augmented corpus. Conversational RuBERT model was chosen for the implementation of the application prototype. The main function of the prototype is to detect the presence of the mention of nine types of green practices in the text. The prototype is implemented in the form of the Telegram chatbot.
Classification of Russian Texts by Genres Based on Modern Embeddings and Rhythm
Authors: Lagutina Ksenia Vladimirovna
Published: December 2022

The article investigates modern vector text models for solving the problem of genre classification of Russian-language texts. Models include ELMo embeddings, BERT language model with pre-training and a complex of numerical rhythm features based on lexico-grammatical features. The experiments were carried out on a corpus of 10,000 texts in five genres: novels, scientific articles, reviews, posts from the social network Vkontakte, news from OpenCorpora. Visualization and analysis of statistics for rhythm features made it possible to identify both the most diverse genres in terms of rhythm: novels and reviews, and the least ones: scientific articles. Subsequently, these genres were classified best with the help of rhythm features and the neural network-classifier LSTM. Clustering and classifying texts by genre using ELMo and BERT embeddings made it possible to separate one genre from another with a small number of errors. The multiclassification F-score reached 99%. The study confirms the efficiency of modern embeddings in the tasks of computational linguistics, and also allows to highlight the advantages and limitations of the complex of rhythm features on the material of genre classification.
The Investigation and Criticism Moral Development Ideas of Kohlberg, Piaget and Gilligan
Authors: Moheghi Mohammadanwar , Ghorbanzadeh Mohammad , Abedi Jalil
Published: December 2022

Ethical growth means the change in how children reason in ethics, their attitude toward law-breaking and, their behavior in dealing with ethical issues. In this article, Kohlberg, Piaget and, Gilligan's views on moral development are mentioned, and their purpose is to compare and critique the views of the scholars mentioned above, together with Muslim scholars on moral development. Although Kohlberg believes that there is no prophecy about the relationship between age and moral development, in his studies ethical growth can be seen as a stage and limited to the age, in his opinion, each individual is at a particular stage in its own, and some His ethical judgments relate to the next stage and the pre-existing stage. Although Kohlberg has been a follower of Piaget in explaining moral development, there are significant differences with his view as Kohlberg extends moral development to the age of twelve. Gilligan's gender criticism of Kohlberg's theory considers the moral ends of his theory masculine. It does not pay attention to eternal moral fundamentals, moral motivation and feeling, good faith and culture, and objective moral behavior and reactions. The results of the verses and narrations indicate that in Islam too, human beings go through stages with their specific characteristics and must take into account their specific stage and conditions but do not specify a specific age range for their moral behavior and judgments, Rather, he views moral development as equivalent to the growth of knowledge and understanding of individuals.
Ratio Legis Regulation of the BPK as the Only One Authorized State Institution Declaring Country Financial Damages in the President of 23 Paragraph (1) Change Constitution of the 1945 Constitution
Authors: Kristanto Kiki , Nurjaya I Nyoman , Madjid Abdul , Djatmika Prija
Published: December 2022

The BPK regulation as the only state institution authorized to declare state financial losses namely in Article 23 of the 1945 constitution (1) confirms the existence of the 1945 RI constitution. As a free and independent financial audit institution, and (2) to face dualism and / or duplication of audit by BPK and BPKP. However, the ratio legis is not reflected in the formulation of the norms of Law 32/1999 in conjuction with Law 20/2001 specifically the explanation of Article 32 paragraph (1) “the amount of losses that can be calculated based on the findings of the competent agency or the appointed public accountant”, thus opening up space to appoint BPK, BPKP, Inspectorate and Public Accountants in calculating and declaring state financial losses or the results of pre-existing calculations can also be used by investigators.
Comparison Between the Effectiveness of Group Hope Training and Neuro-Linguistic Programming (NLP) on Hope and Quality of Life among Children with Cancer
Authors: Aghakhani Sanaz , Bahari Farshad
Published: December 2022

Background: This study was conducted to determine the effectiveness of group hope training and neuro-linguistic programming (NLP) on hope and quality of life among children with cancer.
Methods: This study aimed to determine the effectiveness of group hopefulness and group training of psycho-neurological programming (NLP) on the level of hope and quality of life of children with cancer. This was a quasi-experimental study with pre-test, post-test, and follow-up with a control group. The study participants include all literate 7-18-year-old girls and boys with cancer treated at Amirkabir Hospital (Central Province Children’s Cancer Hospital) and Tabassum Cancer Association (Central Province Cancer Association) in 2016. In total, 60 people were selected by the available sampling method and randomly divided into three groups: group hope training (20 people), NLP (20 people), and a control group without any therapeutic intervention (20 people). The Children’s Quality of Life Questionnaire and the Snyder Children’s Hope Scale were used. Multivariate and one-way analyses of covariance were applied to analyze the data.
Results: There was a significant difference between group hope training and the NLP group. Both interventions had almost the same effect on the quality of life, while group hope training had a higher effect on dependent variables. Results showed that LNP group training led to increased quality of life and hope, predicting 70% and 40% of their variances. In addition, findings showed the effectiveness of group hope training on increased quality of life and hope and could predict 53% and 84% of their variances, respectively. The findings showed that NLP training and group hope training increased quality of life and hope.
Conclusion: According to the findings from this study, LNP group training and hope group training can increase the quality of life and hope. Based on the findings of the present study and the results of previous studies, it can be concluded that group hope and group training of neuro-linguistic programming, based on their basic principles and techniques and changing beliefs and attitudes of individuals and hope for learning, helps children with cancer change the way they react to these events, thus reduce their stress and frustration, and set specific goals for the future that inspires them. These studies show that these psychological interventions lead to positive changes and increase hope and quality of life of children with cancer.