bluuebunny/crossref_metadata_2025 huggingface dataset:
Caspase 14 is differentially expressed in metastasis to the brain in patients with breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that caspase 14, encoded by CASP14, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CASP14 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CASP14 in primary tumors was correlated with patient overall survival. Modulation of CASP14 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
FORMAT-FORMAT BIROKRASI: SEBUAH STUDI TENTANG PENGORGANISIRAN DAN PENYUSUNAN FORMAT DALAM KONTEKS ADMINISTRASI PEMERINTAHAN
Authors: Mualif Akmal
Published: June 2023

Tujuan dari penelitian ini adalah untuk menjelaskan bentuk-bentuk birokrasi yang digunakan dalam konteks pemerintahan. Formulir ini merupakan alat penting untuk mengatur dan mengedit dokumen di instansi pemerintah dan berperan penting dalam menjaga kesinambungan administrasi dan koherensi kebijakan. Penelitian ini dilakukan dengan menggunakan pendekatan kualitatif yang meliputi analisis dokumen, wawancara, dan observasi langsung. Studi ini berfokus pada lembaga pemerintah yang berbeda pada tingkat yang berbeda, seperti pemerintah pusat, pemerintah daerah, dan lembaga pelaksana kebijakan. Melalui analisis rinci format yang digunakan dalam berbagai disiplin ilmu manajemen, pengadaan barang dan jasa, manajemen keuangan dan proses hukum. Tujuan dari penelitian ini adalah untuk mengidentifikasi ciri-ciri umum, perbedaan dan tantangan yang dihadapi oleh pemerintah dalam menggunakan bentuk birokrasi. Hasil penelitian ini menunjukkan bahwa format birokrasi berperan dalam standarisasi prosedur, penyediaan informasi yang konsisten, dan pengelolaan arsip. Meskipun terdapat beberapa kesamaan format yang digunakan oleh instansi yang berbeda, namun terdapat juga variasi dan penyesuaian sesuai dengan kebutuhan spesifik dari masing-masing wilayah administrasi. Selain itu, tantangan utama dalam menggunakan format birokrasi meliputi perubahan regulasi, perbedaan interpretasi dan implementasi, serta kebutuhan penggunaan teknologi informasi yang lebih efisien. Penelitian ini memiliki implikasi penting bagi pengembangan dan perbaikan format birokrasi di instansi pemerintah. Wawasan ini dapat menjadi dasar untuk pengembangan pedoman atau pedoman yang lebih baik untuk pembuatan dan penggunaan format birokrasi yang mempromosikan efektivitas, efisiensi dan transparansi dalam administrasi publik. Selain itu, studi ini memberikan wawasan tentang tantangan pelaksanaan administrasi pemerintahan yang kompleks dan beragam.
Statistical Evaluation of the Mechanical Properties of Cow Dung Ash Concrete
Authors: Moses Omoniyi Tope , Samson Duna , Abba-Gana Moh’d , Abba-Gana Moh’d , Musa Abdullahi
Published: June 2023

Cement is the main binder in the production of concrete for construction activities. Unfortunately, the continuous use of cement results in severe environmental and energy concerns. An established way of reducing carbon footprints and the energy demands associated with cement production is the use of supplementary cementitious material (SCMs). Most supplementary cementitious materials are processed from agro-wastes and bye-products like cow dung. Although cow dung has been utilized as manure, for heating and so on, its use is yet to match the level of production. In this study, the authors propose to investigate the strength performance of cow dung ash as SCMs. Cow dung ash is the product of controlled burning of dried cow dung. Concrete beams and cubes containing 0% to 30% cow dung ash as cement replacement were cured by complete immersion in water for 7,14,28,60 and 90 days. Compressive and flexural strengths decreased as CDA increases; and increased with curing age. Concrete made with 5%, 10%, and 15% CDA and cured for at least 60 days achieved the 28days target compressive strength of 20N/mm2. The strength test results were analysed by analysis of variance (ANOVA) and regression analysis. Proposed regression models showed a strong relationship between the strengths, CDA content and curing age. The proposed models were examined and found to be permissible
CRIP2 is a differentially expressed gene in brain metastatic human breast cancer.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that cysteine-rich protein 2, encoded by CRIP2, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CRIP2 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CRIP2 in primary tumors was correlated with patient recurrence-free survival. Modulation of CRIP2 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
NOL10 is differentially expressed in central nervous system metastasis.
Authors: Mamoor Shahan
Published: June 2023

Metastasis to the brain occurs in a significant fraction of patients with solid tumors including breast cancer and metastatic melanoma (1-3). We mined published RNA-sequencing and microarray data (4, 5), comparing primary and brain metastatic tumor transcriptomes for the discovery of genes associated with metastasis to the CNS. We found that nucleolar protein 10, encoded by NOL10, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. Study of microarray data (5) revealed conserved differential expression of NOL10 in CNS metastasis in patients with metastatic melanoma. NOL10 mRNA was present at increased quantities in metastasis to the brain in humans with breast cancer. Expression of NOL10 in primary tumors of the breast was correlated with patient distant metastasis-free and recurrence-free survival. Modulation of NOL10 expression may be relevant to the biology by which tumor cells metastasize to the brain in humans with solid tumors with propensity for the CNS including breast cancer and metastatic melanoma.
Penerapan Model Pembelajaran Contextual Teaching and Learning (CTL) Untuk Mendukung Hasil Belajar Pada Mata Pelajaran Pendidikan Agama Kristen
Authors: Bessie Maria Liliani
Published: June 2023

Dalam suatu pembelajaran pastinya akan membutuhkan model pembelajaran atau gaya belajar yang tentunya akan digunakan dalam proses belajar. Salah satu model pembelajaran yang dapat digunakan adalah Contextual Teaching and Learning (CTL). Penulisan ini bertujuan untuk mengetahui arti dari Contextual Teaching and Learning (CTL) dan untuk mengetahui bagaimana penerapan Contextual Teaching and Learning (CTL) dapat dilakukan pada mata pelajaran Pendidikan Agama Kristen. Metode yang digunakan dalam penelitian ini adalah metode studi kepustakaan. Teknik pengumpulan data yang digunakan dengan cara membaca dan mencari data lewat buku, makalah ataupun artikel, dan jurnal yang berkaitan dengan judul. Analisis data yang digunakan yaitu dengan menggunakan analisis isi. Hasil dari penelitian ini menunjukan bahwa Contextual Teaching and Learning (CTL) adalah strategi pembelajaran yang dapat membantu guru untuk mengaitkan setiap materi yang diajarkan dengan situasi nyata dari peserta didik dan yang mampu juga untuk memberikan dorongan bagi peserta didik agar dapat menerapkannya dalam kehidupan mereka sendiri. Penerapannya dapat dilakukan dengan cara mengembangkan gagasan berpikir peserta didik, melakukan kegiatan untuk mencari topik yang dipelajari, membangkitkan rasa ingin tahu peserta didik, menciptakan komunitas belajar dan model sebagai contoh pembelajaran dan melakukan evaluasi serta penilaian pada akhir pertemuan.
PANDANGAN PAK DALAM PENGGUNAAN SOSMED (TikTok)
Authors: nino Yonatan
Published: June 2023

catatan terkIt pengguna sosmed (TikTok)
Training Primary School Children’s Uncertainty Monitoring
Authors: Buehler Florian Jonas , Ghetti Simona , Roebers Claudia M
Published: June 2023

Children’s ability to accurately monitor their performance is crucial for self-regulated learning and academic achievement, but interventions are rare. We evaluated a six-time computerized training to improve young primary school children’s uncertainty monitoring with feedback. We assigned the participants (N = 182; M = 7.47 years) either to a metacognitive group, a performance group, or an active control group. Pre and post training, all participants received a baseline recognition memory assessment and provided confidence judgments on each recognition. During training, children in the metacognitive condition received feedback on their memory accuracy and the correspondence between their memory accuracy and their confidence judgments. Children in the performance condition received solely feedback on their memory accuracy. Children in the active control group solved attention control tasks. Other than expected, results revealed that metacognitive and performance feedback did not improve children’s uncertainty monitoring. Important implications for future intervention studies are discussed.
The Role of Visual Working Memory in Capacity-Limited Cross-Modal Ensemble Coding
Authors: Gillies Greer , Fukuda Keisuke , Cant Jonathan
Published: June 2023

Ensemble coding (the brain’s ability to rapidly extract summary statistics, such as average size, from groups of items) aids observers in circumventing the capacity limitation of visual working memory (VWM). Despite this, there are bi-directional interactions between the two systems, although it is unclear if there are cases when VWM may directly support ensemble coding (e.g., generating a summary statistic from information held within VWM). Although ensemble coding is generally viewed as being able to circumvent item capacity limits, capacity limits are observed in the ensemble coding literature. Recently, we encountered a capacity limit (i.e., integration of only four out of six items) in a cross-modal ensemble task where observers were asked to extract the average taste (sweetness) of groups of food pictures. In the present study, we investigated this finding further by examining the role of VWM in explaining the observed capacity limitation. To test this, observers performed both an ensemble task and a VWM task, and we determined 1) how much information they integrated into their cross-modal ensemble percepts, and 2) how much information they remembered from those displays. Across two experiments, we found that individual differences in VWM capacity did not explain differences in performance on the ensemble coding task (i.e., high-capacity individuals did not have significantly higher “ensemble abilities” than low-capacity individuals). While our data cannot definitively state whether or not VWM is necessary to perform the ensemble task, we conclude that it is certainly not sufficient to support this cognitive process. We speculate that the capacity limit may be explained by 1) a bottleneck at the perceptual stage (i.e., a failure to process multiple visual features across multiple items, as there are no singular features that betray taste), or 2) the interaction of multiple cognitive systems (e.g., VWM, gustatory working memory, long term memory). Our results highlight the importance of examining ensemble perception across multiple sensory and cognitive domains to provide a clearer picture of the mechanisms underlying everyday behavior.
Estonian Translation of the Perth Alexithymia Questionnaire/Perthi Aleksitüümia Küsimustiku eestikeelne tõlge
Authors: Sikka Pilleriin , Uusberg Andero , Preece David
Published: June 2023

This is the Estonian version of the Perth Alexithymia Questionnaire. See on Perthi Aleksitüümia Küsimustiku eestikeelne tõlge. Aleksitüümia on konstrukt, mis koosneb kolmest komponendist: raskused oma tunnete tuvastamisel (DIF); raskused oma tunnete kirjeldamisel (DDF); ja väljapoole orienteeritud mõtlemisstiil (EOT), mis tähendab seda, et inimene ei pööra tähelepanu oma emotsioonidele. Teisisõnu, kõrge aleksitüümia tasemega inimestel on raske pöörata tähelepanu oma emotsionaalsetele seisunditele (EOT) ja neid seisundeid täpselt tõlgendada (DIF, DDF) (Preece et al., 2017; Sifneos, 1973). Aleksitüümia tähelepanu-tõlgendamise mudeli kohaselt (Preece et al., 2017) peegeldab inimese aleksitüümia tase tema emotsioone puudutavate skeemide (st emotsioonide tunnetamiseks kasutatavate mõistete, mõttemudelite ja teiste kognitiivsete struktuuride) arengutaset ning emotsionaalsetele seisundite tähelepanuta jäämise määra. Uurimistulemised näitavad, et aleksitüümia on suhteliselt stabiilne iseloomuomadus. Selle tase võib aja jooksul siiski muutuda, näiteks märkimisväärse stressi kogemisel aga ka teraapia tulemusel (nt Luminet et al., 2001). PAQ (Preece et al., 2018) on 24st väitest koosnev aleksitüümia küsimustik, mis on mõeldud kasutamiseks täiskasvanutel ja noorukitel. PAQ mõõdab kõiki aleksitüümia komponente nii negatiivsete kui positiivsete emotsioonide kohta. Küsimustik võimaldab arvutada viis alaskaala skoori ja kuus liitskoori, mis on loetletud allolevas tabelis. Kõrgem skoor näitab kõrgemat aleksitüümia taset. Praktikas kasutatakse ja raporteeritakse kõige sagedamini 5 alaskaala skoori koos skaala koguskooriga. See kombinatsioon on ühtaegu kõikehõlmav kui piisavalt lühike, sobides seega enamike uuringute ja kliiniliste eesmärkide jaoks.
Sequential Analysis of Variance: Increasing Efficiency of Hypothesis Testing
Authors: Steinhilber Meike , Schnuerch Martin , Schubert Anna-Lena
Published: June 2023

Researchers commonly use analysis of variance (ANOVA) to statistically test results of factorial designs. Performing an a-priori power analysis is crucial to ensure that the ANOVA is sufficiently powered, however, it often poses a challenge and can result in large sample sizes, especially if the expected effect size is small. Due to the high prevalence of small effect sizes in psychology, studies are frequently underpowered as it is often economically unfeasible to gather the necessary sample size for adequate Type II error control. Here, we present a more efficient alternative to the fixed ANOVA, the so-called sequential ANOVA that we implemented in the R package “sprtt”. The sequential ANOVA is based on the sequential probability ratio test (SPRT) that uses a likelihood ratio as a test statistic and controls for long-term error rates. SPRTs gather evidence for both the null and the alternative hypothesis and conclude this process when a sufficient amount of evidence has been gathered to accept one of the two hypotheses. Through simulations, we show that the sequential ANOVA is more efficient than the fixed ANOVA and reliably controls long-term error rates. Additionally, robustness analyses revealed that the sequential and fixed ANOVA exhibit analogous properties when their underlying assumptions are violated. Taken together, our results demonstrate that the sequential ANOVA is an efficient alternative to fixed sample designs for hypothesis testing.
Steps Toward Quantum Computational Creativity
Authors: Gabora Liane
Published: June 2023

At the heart of creativity is the forging of new concept combinations and the adapting of existing ideas to new situations. However, these processes have resisted mathematical description; concepts violate the rules of classical logic when they interact, e.g., concept combinations can exhibit emergent features not possessed by their constituent concepts. These challenges can be addressed using the quantum cognition framework, wherein nonclassical behavior is described in terms of superposition, entanglement, and interference. While in classical probability theory events are drawn from a common sample space, in quantum models events are defined only with respect to a measurement, or (in quantum cognition) a context, and the probabilities reflect the underlying reality. The measurement (or context) causes collapse from a superposition state to a definite eigenstate. The paper explains how creativity can be modelled using quantum cognition approach with an illustrative example, and discuss how the approach could be implemented computationally. Quantum computing is widely expected to revolutionize many fields in the near future through immense increases in speed and computing power. The time may be ripe to explore the potential of quantum computational creativity.
Correctional Privatization in the United States: Past, Present, and Future
Authors: Burkhardt Brett C , Edison Story
Published: June 2023

Correctional privatization is big business in the United States. Today, the dominant suppliers of private correctional services—CoreCivic, GEO Group, and MTC—generate billions of dollars in revenue, contract with governments at all levels (federal, state, and local), and provide services in a variety of correctional domains. The modern industry has operated since the 1980s, and historical precursors date to at least the 1800s. With its extensive history, much has been written about private corrections in the US. However, several gaps remain in our knowledge. The goal of this chapter is to survey what we know about the extent, performance, and politics of correctional privatization in the US, while also pointing future researchers and policymakers to promising avenues of inquiry or experimentation.
Preparation and Quality Evaluation of Ready to Serve (RTS) Wheatgrass Juice
Authors: Adhikari Babita , Joshi Sanil
Published: June 2023

Wheatgrass is an inexpensive and efficient source to provide all the required nutrients and medicinal benefits for a healthy body. The major objective of this study is to formulate a health-beneficial beverage that could be organoleptically accepted by people of all age groups, to bring forward a new product from wheatgrass that has mostly remained unexplored. The wheatgrass harvested on the 9th day (optimized on the basis of chlorophyll, tannin, total polyphenols, flavonoids and DPPH radical scavenging activity) was taken for study. The wheat seeds (WK 1204 variety), collected from Agriculture Botany Division, Nepal Agriculture Research Council were used for the preparation of ready-to-serve juice. Eight different formulations of RTS were prepared with the help of Design-Expert®, version 7, keeping juice content 7-13%, TSS 9-16 °Bx and constant acidity at 0.3%. Response Surface Methodology, D-optimal design was adapted for the formulations. The optimization of the formulation was intended to be carried out based on sensory analysis. Proximate and phytochemical (Chlorophyll, Polyphenol, Flavonoids, Tannins and Antioxidant properties) composition of 9th days harvested wheatgrass, its extracted juice and the final product was also carried out. The statistical analysis (two-way ANOVA, no blocking) was done in order to evaluate the outcomes of sensory analysis. There was a significant difference for sensory attributes like flavor, taste, body and overall acceptability at p<0.05, whereas color wasn’t found to be significantly different.  Sensory analysis revealed that the beverage consisting of 12.8% Wheatgrass juice, 12.5°Bx TSS and 0.3% acidity was considered best among all the combinations.
The Limbu Song Palam: A Powerful Means of Inculcating Pragmatic Values
Authors: Tumbahang Mohan Kumar
Published: June 2023

This article, as the statement of the problem, raises the question of whether the Limburaditional song Palam cultivates and instils useful knowledge and skills in practical life. In order to acquire the answer, this article has set the objective to find out the pragmatic values that the Palam song has in the Limbu ethnic community. The article, being descriptive in design, has readily made use of description as its pattern of development. It has used the qualitative research technique which is based on unstructured, non-numerical data drawn from related books, journals, research theses, or Online resources. The song Palam is concerned with ethnic as well as cultural issues, and for this reason, the article has chosen the ethnocultural theory which deals with ethnic identity-based cultural practices, traditional customs, and social behaviour. The theory also refers to a group of people who have a belief that they are ethnically and culturally divergent from other groups or communities. The analysis has revealed that the folk-song Palam has long been tacitly inculcating very significant as well as useful knowledge and skills to the community even though certain native individuals find it of no use at all. From this article, it is fairly expected that interested individuals and anthropologists can acquire specific insights from the Limbu culture and traditional song Palam.
भाषा शिक्षणमा सूक्ष्म तथा सहपाठी शिक्षणको प्रयोगात्मक ढाँचा, स्वरूप र उपादेयता
Authors: नेपाल शक्तिराज
Published: June 2023

भाषा शिक्षणमा सूक्ष्म तथा सहपाठी शिक्षणको प्रयोगात्मक ढाँचा, स्वरूप र उपादेयता नै यस लेखको शीर्षक हो  ।  भाषा शिक्षणमा भाषाका चारवटै सिपको एकीकृत शिक्षण गरिन्छ । भाषाका सिपको विकास हुनु नै भाषा शिक्षणमा सिकाइ उपलब्धि हो । भाषा शिक्षणको प्रकृति नै प्रयोगात्मक छ । विषयको प्रकृति नै प्रयोगात्मक हुने भएकाले यसमा नीतिगत रूपले नै सैद्धान्तिक तथा प्रयोगात्मक भनी कोर्स वा पाठ्यवस्तु छुट्याइएको हुन्छ  ।  भाषा शिक्षणका सन्दर्भमा शिक्षण अभ्यासको महत्वपूर्ण भूमिका हुन्छ । भाषा शिक्षणको पठनपाठन सैद्धान्तिक प्रकृतिको हुने भएकाले शिक्षण अभ्यासको कार्यक्रम राखी यसलाई थप प्रयोगात्मक र पारदर्शी बनाउन खोजिएको हो ।  शिक्षण अभ्यासले विद्यार्थीलाई पूर्ण शिक्षक बन्ने अभ्यास गर्ने मौका दिन्छ । शिक्षण अभ्यास कार्यक्रममा जम्मा तीन तहका अभ्यासात्मक कार्यक्रमहरू हुन्छन: सूक्ष्म शिक्षण, सहपाठी शिक्षण र स्कुल तथा क्याम्पस वा कलेज शिक्षण  ।  यो कार्यक्रम भनेको शिक्षार्थीका लागि वास्तविक शिक्षक बन्ने तथा अग्र एवं पृष्ठपोषण सङ्कलन गर्ने अभ्यासको कार्यक्रम हो ।  शिक्षकले सानो आकारको विद्यार्थीको कक्षामा कसरी शिक्षण गर्ने, ठुलो आकारको विद्यार्थी सङ्ख्या भएका कक्षामा कसरी शिक्षण गर्ने भन्ने कुराको अभ्यास क्याम्पस वा कलेजमा नै गर्ने गराउने भएकाले यस कार्यक्रमलाई पूर्व स्कुल/क्याम्पस शिक्षण कार्यक्रम र पश्च स्कुल कार्यक्रम गरी दुई चरणमा अभ्यास गराउने गरिएको छ । यसै प्रसङ्गमा यस लेखमा भाषा शिक्षणका सन्दर्भमा सूक्ष्म शिक्षण र सहपाठी शिक्षणको सैद्धान्तिक अर्थ, प्रयोग, महत्त्व, कक्षाकोठाको स्वरूप, तरिका र पद्धतिका बारेमा चर्चा गरिएको छ । पुस्तक कार्यको प्रक्रिया तथा विभिन्न अनुसन्धानात्मक सामग्रीहरूको अध्ययन गरी सैद्धान्तिक ढाँचा निर्माण गरिएको छ । वर्णनात्मक दार्शनिक आधारमा संरचित यस लेखमा गुणात्मक पद्धति तथा पुस्तक पठन विधिलाई अपनाइ सामग्रीको विश्लेषण गरिएको छ । भाषा शिक्षणलाई शैक्षिक क्रियाकलापका रूपले पनि औचित्यपूर्ण बनाउन यस लेखले सहयोग पुर्याउने देखिएको छ ।
मोदिआइन उपन्यासमा मानवतावाद
Authors: न्यौपाने सुभाषचन्द्र
Published: June 2023

प्रस्तुत लेख उपन्यासकार विश्वेश्वरप्रसाद कोइरालाको मोदिआइन उपन्यासमा प्रयुक्त मानवतावादी दृष्टिकोणमा आधारित छ । उपन्यासकार कोइरालाको २०३६ सालमा प्रकाशित पौराणिक मिथकमा आधारित यस उपन्यासमा केकस्ता मानवतावादी विचारको प्रस्तुति केकसरी भएको छ र मानवताका पक्षमा केकस्ता दृष्टिकोणहरू प्रस्तुत भएका छन् भन्ने कुराको विश्लेषण यस लेखमा गरिएको छ । प्रस्तुत लेख तयारीका क्रममा प्राथमिक सामग्रीका रूपमा उपन्यासकार विश्लेश्वरप्रसाद कोइरालाको मोदिआइन उपन्यासलाई लिइएको छ भने द्वितीयक सामग्रीका रूपमा मानवतावादी चिन्तनसँग सम्बन्धित सामग्रीहरू तथा मोदिआइन उपन्यासका सन्दर्भमा प्रकाश पारी लेखिएका पुस्तक, पत्रपत्रिका, शोधप्रतिवेदन आदिको उपयोग गरिएको छ । सामग्री विश्लेषणका क्रममा निगमनात्मक विधिअनुसार स्थापित सिद्धान्तका आधारमा वर्णनात्मक, विश्लेषणात्मक र व्याख्यात्मक विधिको प्रयोग गर्दै अन्त्यमा अर्थापनविधिद्वारा लेखलाई पूर्णता दिइएको छ । मानवतावादी दर्शनका आधारमा प्रस्तुत उपन्यास सशक्त र सार्वभौम छ भन्ने निष्कर्ष प्रस्तुत लेखको विश्लेषणबाट निकालिएको छ ।
Rock Squeezing Analysis in Young Mountains: A Case Study of Headrace Tunnel of Supermadi Hydroelectric Project in Nepal
Authors: Joshi Dev Raj , Panthee Suman
Published: June 2023

The tunnel stability was assessed by analysing stress in the opening. Squeezing is the major problem faced while excavation a tunnel alignment in Himalayan region. This research was done in Super Madi hydroelectric project of 44 MW, in which main focus on the rock mass section of headrace tunnel of Inverted D shaped. The prediction of squeezing is done using various empirical, semi empirical, semi analytical and numerical modeling for the three different rock class. Finite element analysis was done using Rock science Phase2 software and output was verified by site investigation. The main lithologies of the area along the tunnel axis are banded gneiss. Based on the site condition, this study recommend the accurate method of predicting rock squeezing in the lesser Himalayan region with similar site conditions. It is found that the higher deformation occurs in high tunnel depth with low Q value.
Experience and Expectation of Socialism: Principle versus Practice in Nepal
Authors: Paudel Rudra Prasad
Published: June 2023

This article discusses Nepali people’s experience with socialism and their expectations by addressing these questions: What is socialism? Which socialism do Nepali people expect? Why do they expect socialism? How does the principle go against the practice in the context of Nepal? Qualitative secondary sources are critically analyzed as methodological tools to reveal the present experience and expectations of Nepali people. It presents the disparity between principle and practice demonstrated by the Nepali political parties. The Constitution of Nepal2015 has formally promised that the guiding political-economic principle of this state is socialism-oriented. However, the sayings and doings of major political parties in Nepal have a big gap. In their doings, they are highly influenced by liberal capitalist principles, and they continue implementing neo-liberal policies. They put forward liberal bourgeois policies and programs that suited the interest of the comprador bourgeoisie. Thus, we have seen a contradiction in their implementation of the socialist principle, which goes against the expectation of the Nepali people. By pointing out this gap, this article highlights the need for serious discussions on achieving socialism as stated in Nepal’s constitution and expected by the people while also drawing the attention of the political actors to take immediate and radical actions to correct their behaviors in time in order to achieve the goal of a Socialism Nepal.
Estimation of Global Solar Radiation using Angstrom and Gopinathan Model on Sunshine Hour and Temperature in Highland, Nepal
Authors: Saud Jay S. , Shrestha Prakash M. , Joshi Usha , Tiwari Babu R. , Karki Indra B. , Poudyal Khem N.
Published: June 2023

In developing countries like Nepal, the direct measurement of global solar radiation (GSR) is difficult. So, the estimation of GSR is carried out at Jumla (29°16′ N, 82° 11′ E and about 2347 m altitude) for the year 2015 and 2017 using regression technique to the meteorological parameters on Angstrom model, Gopinathan and Olomiyesan- Oyedum models. Among three models, Olomiyesan and Oyedum model is better than other models. Its empirical constants a=0.38, b=0.10 and c=0.09 are found. The values of statistical errors MBE, MPE and RMSE are smaller than other models. Similarly, the coefficient of determination (R2=0.89) is greater than other models. Finally, the finding empirical constants and meteorological parameters sunshine hour, and temperature are used to estimate the GSR for the year 2017. In addition to this, the annual average GSR for the year 2015 and 2017 are found to be 18.86 MJ/m2/day and 17.50 MJ/m2/day respectively. It is concluded that the finding empirical constants are used to estimate the GSR and solar energy at similar geographical location of Nepal.
Aequitas canonica and Access to the Sacrament of Penance during the First Wave of COVID-19 in 2020 in the Light of the Principles of Canon Law
Authors: Němec Damián
Published: June 2023

Epidemiological measures during the first wave of the coronavirus epidemic in 2020 significantly affected the realization of religious freedom, including religious services and sacraments. This paper deals with one narrower topic in this area, namely, the regulation of access to the sacrament of penance in response to measures of secular law. It focuses mainly on the modalities of allowing access to this sacrament in the Catholic Church, both in terms of universal law and in terms of particular law and proposals for its formulation.
The Missing Concordat in the Czech Republic
Authors: Přibyl Stanislav
Published: June 2023

The present article discusses certain aspects of the Treaty between the Czech Republic and the Holy See. The text of the treaty was signed at the level of the government, however, it has not been ratified so far. Some provisions of the treaty are rather superfluous or lack sufficient normative basis. Nevertheless, as the example of Article 9 of the treaty on the recognition of civil effects of church marriages shows that the approval of the treaty by the Parliament of the Czech Republic would have been very beneficial. In fact, in the process of preparation for a new civil code an attempt was made to repeal church marriages recognized by the state. Such a project would have been made impossible by the concordat because church marriage would have been supported by an obligation of the state under international law. Fortunately, the civil code kept church marriages, and confessional law in the Czech Republic has to develop without a valid concordat.
Stanislav Přibyl, Kanonické manželské právo. Nová Ves pod Pleší: Hesperion, 2021, 175 pp.
Authors: Němec Damián
Published: June 2023

W recenzji przedstawiono monografię Kanoniczne prawo małżeńskie autorstwa Stanisława Pribyła, która jest przeznaczona jako tekst dla studentów wydziałów prawa. Poza przedmową i zakończeniem monografia podzielona jest na 16 rozdziałów, przy czym najwięcej miejsca poświęcono problematyce zgody małżonków, zgodnie z jej doktrynalnym i prawnym znaczeniem, nawet poprzez częste podawanie przykładów z praktyki sądowej, zwłaszcza w zakresie braków zgody małżonków - jest to niezwykle cenny walor tej pracy. Uwzględnia również świeckie prawo rodzinne, zwłaszcza czeskie, a także prawo innych kościołów chrześcijańskich. Niniejsza monografia ma zatem również wymiar ekumeniczny.
Socio-Economic and Literacy status among Halba Tribes of Bastar, Chhattisgarh
Authors: Tirkey Sukrita
Published: June 2023

The government of India launched several programs to combat the socio-economy challenges of tribes. Despite the available facilities for schedule tribes are attached to illiteracy and old modes of earning recourse. Despite Government programs India literacy rate increased only and a 1990 study estimated that it would take until 2060 for India to achieve universal literacy at current rate of progress. The present study was conducted to find out the socio-economic conditions of Halba tribes of Madpal, Bastar district of Chhattisgarh. Socio-economic status and health are closely related and socio-economic status can often have profound effects on a person's health due to differences in ability to access health care as well as dietary and other lifestyle choices that are associated with both finances and education. The present study highlights a high. prevalence of illiterate and poor economic conditions which needs urgent intervention. In what way of looking at how individuals or Halba families fit into society using economic and social measures that have been shown on their present condition.
Comparison of temporal cavity indicators when firing “FORT 12R” and “AE 790G1” into a non-biological body simulator
Authors: Kusliy Yu. Yu. , Shkolnikov V. S. , Shevchuk Yu. G. , Fomin O. O. , Zverkhovska V. F.
Published: June 2023

Gunshot injuries are extremely dangerous due to the extremely unpredictable compliance of ammunition after contact with the body. One of the key elements that takes place in this case is the formation due to high kinetic energy of a temporary cavity, which, despite its existence for a fraction of a second, causes severe damage to the tissues of the human body. The study of this phenomenon is one of the central elements of ballistics and requires an experiment on optically transparent media. The purpose of the study is to compare the parameters of the temporal cavity when fired from the “FORT 12R” and “AE 790G1” pistols into a non-biological simulator of the human body. To achieve the goal, 120 gelatin blocks were produced according to the generally accepted method, which were to be shot at close range, 25 and 50 cm. The blocks were left bare before shooting, or covered with cotton fabric, denim fabric or leatherette. After firing, transverse sections of the blocks were made in order to further measure the parameters of the temporary cavity formed as a result of the firing, according to generally accepted methods. The results of the analysis of the received data regarding the indicators characterizing the dimensions of the temporary cavity at different depths of the wound channel revealed a number of significant differences (p<0.05-0.01) between the studied pistols (in almost all cases, “AE 790G1” had larger values), groups of blocks covered with different types of fabrics, bare blocks (in almost all cases, the clothing had protective properties and reduced the size of the temporary cavity) and allowed to establish that during shots from the “FORT 12R” there was a sharp increase in the size of the temporary cavity with its sharp decrease at the end of the wound channel, while with shots from the “AE 790G1” the temporary cavity gradually increases, reaching a maximum at half the depth and then just as gradually decreases. Thus, when comparing the “FORT 12R” and “AE 790G1” pistols, differences in the features of the formation of the temporary cavity were revealed, which in turn is of interest not only for forensics, ballistics and forensic medicine, but also for clinical medicine.
A Survey of Canadian Dietitians on Identification of Infants at High Risk of Food Allergy and Frequency of Allergenic Food Consumption
Authors: Wingate Kirstin E. , Gerdts Jennifer , Soller Lianne , Chan Edmond S.
Published: June 2023

Purpose: To assess knowledge of Canadian dietitians on the topics of food allergy and food allergy prevention guidelines, including introduction of allergenic solids to infants at risk of food allergy.

Methods: An online survey was distributed via email listservs targeting Canadian dietitians.

Results: In total, 144 of 261 dietitians completed the survey (60.5%). Respondents recommend introduction of peanut (89.5%) and allergenic solids (91.2%) within the recommended age of 4–6 months for infants at high risk of food allergy, but only 26.2% recommend offering peanut three times per week once it has been introduced. In identifying what constitutes an infant at high risk of developing peanut allergy, dietitians expressed lower comfort levels and lower number of correct responses.

Conclusions: Dietitians demonstrated they are up to date regarding the timing of introduction of allergenic solids, but not the frequency of consumption once introduced, for infants at high risk of food allergy. They also expressed low comfort level identifying risk factors for peanut allergy. There are opportunities for further education of dietitians, as well as potential to further utilize dietitian services for the benefit of patients with food allergy or who are at risk for food allergy.
Role of fibro-adipogenic progenitors in skeletal muscle aging
Authors:   Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China, Wan Renwen , Zhang Hanli ,   Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China, Liu Shan ,   Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai 200040, China, Jiao Chunmeng ,   Guangdong Pharmaceutical University, Guangdong, China, Chen Hui ,   Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Shanghai Medical College, Institute of Acupuncture Research, Institutes of Integrative Medicine, Fudan University, Shanghai 200040, China, Luo Zhiwen ,   Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China, Shang Xiliang ,   Department of Sports Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China
Published: June 2023

Maintaining muscle mass is of paramount importance from a clinical perspective as it supports the flexibility, strength, and essential daily tasks that the body requires. Furthermore, muscle plays a role in regulating the body’s metabolic system. Unfortunately, aging can lead to a loss of muscle mass, which can reduce personal independence and quality of life while increasing the risk of developing disease. Fibro-adipogenic progenitor cells (FAPs) are muscle-resident progenitor cells that are essential for maintaining skeletal muscle fiber size and muscle regeneration. These vital FAP functions are mediated by a complex secretome that interacts in a paracrine manner to promote the division and differentiation of muscle satellite cells. Dysregulated differentiation of FAPs can lead to fibrosis, fatty infiltration, muscle atrophy, and poor muscle regeneration. In this article, we review what is currently known about how FAPs function in aging muscle and how they may prevent the onset of muscle wasting and degeneration. Finally, we discuss how FAPs represent a population of cells that can be used as therapeutic targets to improve the health of skeletal and muscle tissues as they age.
A religião nas relações de poder: a permanente influência das figuras religiosas na esfera pública brasileira
Authors: Da Ponte Isadora Sorteia , Hahn Noli Bernardo
Published: June 2023

Este artigo teve como objetivo estudar a relação histórica existente entre a política brasileira e a religião, além dos possíveis reflexos que essa união possa ter causado na esfera pública do país. Assim, percebeu-se que o Brasil foi construído em sua origem por percepções religiosas, as quais marcaram, inquestionavelmente, a formação do direito e da cultura do país. Nesse sentido, após a separação oficial do Estado e da Igreja, as instituições continuaram se relacionando, ainda que simbolicamente. Na reflexão, tem-se como base a lógica dedutiva, com abordagem analítico-interpretativa e procedimento bibliográfico. Dessa forma, a pesquisa debruçou-se em estudar a história brasileira vinculada às raízes religiosas, analisando de que forma estas, ao logo do tempo, foram se enraizando na cultura do país de tal forma que, atualmente, não podemos pensar em sociedade, direito e política sem nos deparar com regramentos de diversas entidades religiosas. A principal hipótese é que, mesmo após a consolidação do Estado laico, a religião continuou influenciando os três poderes do Brasil, observando-se que alguns representantes do povo permanecem justificando suas decisões mediante ideologias religiosas, as quais, por vezes, dificultam o desenvolvimento da democracia brasileira, impedindo que direitos individuais e coletivos sejam alcançados em razão de interpretações equivocadas de textos sagradosEste artigo teve como objetivo estudar a relação histórica existente entre a política brasileira e a religião, além dos possíveis reflexos que essa união possa ter causado na esfera pública do país. Assim, percebeu-se que o Brasil foi construído em sua origem por percepções religiosas, as quais marcaram, inquestionavelmente, a formação do direito e da cultura do país. Nesse sentido, após a separação oficial do Estado e da Igreja, as instituições continuaram se relacionando, ainda que simbolicamente. Na reflexão, tem-se como base a lógica dedutiva, com abordagem analítico-interpretativa e procedimento bibliográfico. Dessa forma, a pesquisa debruçou-se em estudar a história brasileira vinculada às raízes religiosas, analisando de que forma estas, ao logo do tempo, foram se enraizando na cultura do país de tal forma que, atualmente, não podemos pensar em sociedade, direito e política sem nos deparar com regramentos de diversas entidades religiosas. A principal hipótese é que, mesmo após a consolidação do Estado laico, a religião continuou influenciando os três poderes do Brasil, observando-se que alguns representantes do povo permanecem justificando suas decisões mediante ideologias religiosas, as quais, por vezes, dificultam o desenvolvimento da democracia brasileira, impedindo que direitos individuais e coletivos sejam alcançados em razão de interpretações equivocadas de textos sagrados.
Service Quality, Trust as a Moderating Variable, Security and Perceived Risk of Purchasing Decisions at Shopee
Authors:   Sriwijaya University, M. Ilham Akbar M. Ilham Akbar
Published: June 2023

Abstract. Introduction. Consumers should also carefully consider the purchase of a product online, as online buying and selling cannot be separated from the issue of risk. This phenomenon mainly results from the fact that most transactions between sellers and buyers are conducted over the internet, where fraud, lack of privacy, delivery risk, and lack of quality assurance of goods are commonplace. Purpose. This study aims to obtain empirical evidence by understanding and analyzing the impact of service quality with trust as a moderating variable on purchasing decisions, the impact of service quality on purchasing decisions, the impact of safety on purchasing decisions, and the impact of perceived risk on purchasing decisions at Shopee. This study used a sample of 160 18- year-old male and female residents of South Sumatra who had used the Shopee application-selected using a sampling technique for a specific purpose. The research was analyzed using descriptive statistical methods with data on the frequency of respondents' responses regarding the given variables and Statistical Product and Service Solutions (SPSS). Results. Results of the study indicating that the trust variable significantly moderates the effect of service quality on purchasing decisions, service quality influences a positive effect on purchasing decisions, and security has a positive effect on purchasing decisions. Conclusions. Trust significantly moderates the effect of service quality on purchasing decisions at Shopee. Service quality has a significant effect on purchasing decisions at Shopee. Security has a significant effect on purchasing decisions at Shopee. Perceived risk has a significant effect on purchasing decisions at Shopee.
The Essence and Place of Cryptocurrency in the Financial System
Authors:   Lviv National University of Nature Management, Kohut Maryana
Published: June 2023

Abstract. Introduction. The history of the emergence of Bitcoin and other cryptocurrencies is analyzed. Basic concepts related to blockchain technology are explained. The main focus is on issues important from an investor's point of view, as well as on technical aspects, including the essence and importance of blockchain technology. Purpose. The purpose of the article is to generalize and systematize the available information about the emergence of cryptocurrencies and analyze their patterns. Results. The specifics of digital assets and the bitcoin exchange rate in 2012-2021 were studied in more detail. It was found that on the cryptocurrency market you can earn (as well as lose) both as a trader and as a so-called cryptocurrency hodlers. A rating of cryptocurrency exchanges was developed according to the following indicators: security, number of crypto currencies, fiat currencies, advantages of the exchange, disadvantages of the exchange. Cryptocurrency exchanges are a central part of the entire digital collection ecosystem today. Currently, there are already several hundred crypto exchanges on the market, which differ in terms of transactions, security levels or listed values. In this article, we have described cryptocurrency as objectively as possible so that you can assess for yourself whether it will be the right form of investment for you. Conclusions. The wide choice of service providers and the fact that digital currencies are a relatively new form of investment means that finding the best place to trade is not easy. The cooperation of international financial conglomerates in the development of blockchain technology will save these enterprises billions of dollars per year and will be able to improve their operations and eliminate errors related to the human factor. Participants in the financial system are forced to propose standards that would apply to each participant in the network without disturbing the established status quo in international markets.
Reasons for the Growth of Foreign Labor Migration
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Samborska Oksana
Published: June 2023

Abstract. Introduction. In the conditions of intensive migrations, the need to regulate such processes is increasing, there is a need to use the positive potential of labor migrations for the purpose of development, minimizing negative consequences, ensuring the rights and freedoms of migrants. That is why reducing migration should be one of the priority tasks of the country's state migration policy. As a result of the fact that Ukraine is at the same time the country of origin, destination and transit of migrants, the territory of migration flows of different characteristics, different directions and different scales, ensuring state regulation in the field of migration is a complex task, the solution of which requires a complex, systematic approach, adequate funding, personnel and scientific software. The modern migration processes taking place in Ukraine are influenced by several important factors, which turned out to be insufficiently decisive and consistent, the promotion of European and Euro-Atlantic integration, in particular, the acquisition of a visa-free regime with the European Union. The migration experience and extensive networks formed as a result of the long-term participation of Ukrainians in migrations are a negative process for the socioeconomic development of the country. Purpose. The desire of Ukrainians to improve their material situation is always a motive for migration, directly economic, both within the country and abroad. Since income from employment is the main component of financial status, labor migration is most characteristic of residents of low-wage countries. Today, it is very important to set the right vector in the direction of preserving and using the labor potential of Ukraine, for the development and uplifting of the economy as a whole. Results. Study of external migration of labor potential and determination of the consequences of social and psychological stress in families. To draw parallels between the level of actual unemployment of Ukrainians and changes in the real income of their families, as one of the reasons for the increase in external labor migration of the population. Conclusions. The importance of the implementation of direct functional duties of state authorities: promoting the creation of new jobs for the unemployed, preventing the mass exodus of young people and the able-bodied population, controlling and regulating the demographic crisis, combating unregulated migration.