bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Nearest Level Modulation Method with Increased Output Voltage Quality for Modular Multilevel Converter Topology
Authors: Kurtoğlu Mehmet , Vural Ahmet Mete
Published: February 2022

The modular multilevel converter (MMC) topology is gaining more interest because of its modular design, high efficiency, and scalable voltage levels in medium- and high-power industrial applications, where the nearest level modulation (NLM) method is frequently preferred. In this paper, a novel NLM method is proposed with increased output voltage quality for MMC topology. In conventional NLM (C-NLM), output voltage is obtained as N + 1 levels, where N is the number of submodules (SMs) per arm. The output voltage is increased to 2N + 1 levels by the proposed NLM method without using any additional SMs. The proposed NLM method is based on the offset term injection, which is optimally determined in terms of the best output performance of MMC. Also, trapezoidal reference signal is used instead of sinusoidal reference, which provides better output voltage quality and controls the modulation process. The proposed NLM method presents simple implementation as in the C-NLM, and it is implemented to the upper and lower arms of the MMC; then, arm voltages are successfully controlled. Furthermore, output voltage returns the value of zero in the C-NLM process for low-modulation-ratio applications in relatively small amount of SM usage of MMC design. However, the proposed NLM method gives promising results instead of zero voltage. In order to validate the superior performance of the proposed NLM method, a comparative study is presented with C-NLM and third-harmonic injected NLM method in terms of total harmonic distortion (THD) and magnitude of the output voltage and current. THD of output waveforms of MMC is significantly reduced, and DC voltage utilization is remarkably increased, thanks to the proposed NLM method. In addition, capacitor voltage balancing for the proposed NLM method is accomplished to keep the capacitor voltage of each SM of MMC constant. Simulation results are presented to verify the effectiveness of the proposed NLM method under various case studies. Finally, experimental validation is carried out using a field programmable gate array (FPGA)-based hardware implementation on the laboratory prototype to show the applicability of the proposed NLM method.
Colonic Adenocarcinoma with Plasmacytoid Feature: Histopathology and Molecular Characteristics of a Rare Neoplasm with an Unusual Presentation
Authors: Marji Noor , Dhillon Jasrerman , Lauwers Gregory Y. , Feuerlein Sebastian , Nikfar Reza , Chatwal Monica , Vosoughi Aram
Published: February 2022

Colorectal carcinoma with noncohesive tumor cells has been described in tumors with signet ring cells (mucinous adenocarcinoma and signet ring cell adenocarcinoma) and rhabdoid feature (carcinoma with sarcomatoid component). Cases of carcinoma with plasmacytoid morphology are rare in the gastrointestinal tract, and a single case of plasmacytoid colorectal carcinoma has been reported. We report the case of a 37-year-old woman who presented with urinary symptoms, hematuria, and abdominal pain. Imaging studies showed segmental sigmoid wall thickening with pericolic infiltration and focal bladder wall thickening. The cystoscopy with transurethral resection of bladder tumor revealed muscle invasion, dis-cohesive carcinoma with plasmacytoid morphology, which was initially misdiagnosed as the plasmacytoid urothelial carcinoma. Immunohistochemical stains showed the tumor cells to be positive for CDX2, CK20, and SATB2 and negative for p63, GATA3, CK7, and Uroplakin II, indicating the colorectal origin of the tumor. The subsequent colonic wall biopsy showed the same tumor. Molecular studies identified BRAF V600E, SMAD4, and p53 mutations associated with aggressive colorectal adenocarcinoma with mucinous/signet ring cell features. Further whole-exome sequencing and whole transcriptome analysis confirmed the colorectal origin of the tumor. This rare colorectal adenocarcinoma with the plasmacytoid feature may represent the signet ring cell adenocarcinoma lacking extracellular mucin or intracellular vacuole. Diagnosis of this rare histological subtype of colorectal carcinoma is important, particularly in the unusual presentation of this aggressive tumor.
Homocysteine Is a Marker of Increased Cardio-Cerebrovascular Disease Risk in Psoriatic Patients, but It Does Not Reflect the Effect of Biological Therapy in the Longitudinal Observation
Authors: Baloghova Janette , Feketeova Eva , Kolarcik Peter
Published: February 2022

Background. Psoriasis is linked to atherosclerosis. Homocysteine (HCYS) has been identified as a marker of increased risk of cardio-cerebrovascular diseases (CCVD) in population. Objective. The aim of the study was to determine whether elevated HCYS serves as a marker of increased CCVD in psoriasis and whether biological therapy for long-term monitoring influences HCYS levels. Methods. Clinical data, laboratory tests, and comorbid diagnoses were summarized for the two groups of patients based on entrance HCYS levels. Patients (n = 76) were included in the follow-up gradually over a period of 5 years. Results. The psoriatic patients with normal (54%) and elevated (46%) HCYS before biological treatment did not vary in clinical data, laboratory tests, treatment, and comorbid diagnoses apart from CCVD. Elevated HCYS group showed a four-fold excess of CCVD (OR 4.2, 95%CI 1.21–4.86,p=0.024). HCYS levels in the longitudinal observation did not vary. Conclusion. An increased CCVD risk, independent of other risk factors, is present in psoriatic patients with elevated HCYS. The HCYS level was not influenced by biological therapy in longitudinal observation. Further studies are needed to explore if elevated HCYS could serve as a marker of increased CCVD in any stage of psoriasis and if it should be included in classical screening strategies.
Behavior Choice and Emission Reduction in a Dynamic Supply Chain with a Capital‐Constrained Retailer
Authors: Wan Shihao , Zhang Jiahui , Cheng Xianxue
Published: February 2022

This paper studies the dynamic optimization of a low‐carbon supply chain consisting of a manufacturer and a capital‐constrained retailer. Considering market randomness and accumulation of production experience, a Stackelberg differential game model is constructed. In the game, the manufacturer is the leader and its pricing and emission reduction strategies over time are deduced in farsighted and myopic behaviors, respectively. In both behaviors, the emission reduction increases over time and a relatively low/high carbon price leads to skimming/penetrating pricing strategy of the manufacturer. Numerical study shows that the manufacturer must adopt a farsighted behavior for profit seeking except that consumers’ low‐carbon awareness is quite low, and the retailer also prefers the manufacturer to adopt this behavior. Increasing carbon price and consumers’ low‐carbon awareness benefits the manufacturer rather than the retailer. The governments can take measures to raise the carbon price to reduce the environmental impact.
Landscape Genetics and Species Delimitation in the Andean Palm Rocket Frog (Aromobatidae, Rheobates)
Authors: Genty Gabrielle , Guarnizo Carlos E. , Ramírez Juan P. , Barrientos Lucas S. , Crawford Andrew J.
Published: February 2022

The complex topography of the species-rich northern Andes creates heterogeneous environmental landscapes that are hypothesized to have promoted population fragmentation and diversification by processes such as vicariance or local adaptation. Previous phylogenetic work on the palm rocket frog (Anura: Aromobatidae: Rheobates spp.), endemic to midelevation forests of Colombia, suggested that valleys were important in promoting divergence between lineages. In this study, we first evaluated previous hypotheses of species-level diversity, then fitted an isolation-with-migration (IM) historical demographic model, and tested two landscape genetic models to explain genetic divergence within Rheobates: isolation by distance and isolation by environment. The data consisted of two mitochondrial and four nuclear genes from 24 samples covering most of the geographic range of the genus. Species delimitation by Bayesian Phylogenetics and Phylogeography recovered five highly divergent genetic lineages within Rheobates, among which few to no migrants are exchanged according to IM. We found that isolation by environment provided the only variable significantly correlated with genetic distances for both mitochondrial and nuclear genes, suggesting that local adaptation may have a role in driving the genetic divergence within this frog genus. Thus, genetic divergence in Rheobates may be driven more by variation among the local environments where these frogs live rather than by geographic distance.
Decomposition-Coordination-Based Voltage Control for High Photovoltaic-Penetrated Distribution Networks under Cloud-Edge Collaborative Architecture
Authors: Han Xutao , Zhang Yajian
Published: February 2022

With the integration of high proportional photovoltaics (PVs) into distribution networks, the superposition of uncertain output power of PVs and stochastic load demand fluctuations have posed a serious challenge to voltage stability. In this paper, a multitimescale decomposition-coordination-based voltage control method is proposed under the cloud-edge cooperative architecture. The distribution network is firstly decomposed into several subnetworks. In each subnetwork, the edge computing device is equipped to realize the distributed control and provide external computing resources for the cloud center. Then, a multitimescale control scheme containing the interval dispatch stage and the real-time time-window stage is proposed. In the interval dispatch stage, a cloud-edge collaborative calculation strategy considering balanced resource allocation is well designed to obtain the global optimal power flows and the corresponding reference operating points of the voltage control equipment. Meanwhile, in the real-time time-window stage, a consensus-based voltage correction mechanism under the optimal power flow boundary constraints is designed to avoid the voltage violations caused by unexcepted power fluctuations deviating from the representative scenarios. Simulation results with the improved 33-bus and IEEE 123-bus systems have demonstrated the effectiveness of our proposed method.
Diagnostic Value of Model-Based Iterative Algorithm in Tuberculous Pleural Effusion
Authors: Xi Suya , Sun Jinhao , Wang Hongjing , Qiao Qingzhe , He Xianghong
Published: February 2022

Although there are several diagnostic modalities for tuberculous pleurisy, there is still a lack of easy, cost-effective, and rapid methods for confirming the diagnosis. In order to facilitate clinicians to diagnose patients with tuberculous pleurisy at an early stage, help patients to obtain treatment early, and reduce lung damage, it is hoped that new techniques will be available in the future to help diagnose tuberculous pleurisy rapidly in the clinic. To this end, this paper investigates the problem of bidirectional consistency based on event-triggered iterative learning. Firstly, a dynamic linearized data model of TB pleurisy intelligent system is established using compact-form dynamic linearization method, and a parameter estimation algorithm of TB pleurisy data model is proposed; then, based on this data model, an output observer and a dead zone controller are designed, and an event-triggered distributed model-free iterative learning bidirectional consistency control strategy is constructed by combining with signal graph theory. In this paper, 112 patients with pleural effusion were collected, including 76 patients with confirmed or clinically diagnosed tuberculous pleural effusion and 36 patients with nontuberculous pleural effusion. Pleural effusion T-SPOT.TB, blood T-SPOT.TB, pleural effusion Xpert MTB/RIF, and pleural effusion adenosine deaminase (ADA) tests were performed before treatment in the included patients. The sensitivity of pleural effusion T-SPOT.TB was higher than that of peripheral blood T-SPOT.TB (76.32%, 58/76), pleural effusion Xpert MTB/RIF (65.79%, 50/76), and pleural effusion ADA (28.95%, 22/76); the differences were statistically significant (x2 = 14.74, 25.22, and 76.45, P < 0.01). The specificity of the Xpert MTB/RIF test for pleural effusion (100%, 36/36) was higher than that for pleural effusion T-SPOT.TB (77.78%, 28/36), peripheral blood T-SPOT.TB, and pleural effusion T-SPOT.TB. The sensitivity of the combined Xpert MTB/RIF test (64.47%, 49/76) was lower than that of the pleural effusion T-SPOT.TB alone (97.37%, 74/76).
The Role of ANRIL in Atherosclerosis
Authors: Razeghian-Jahromi Iman , Karimi Akhormeh Ali , Zibaeenezhad Mohammad Javad
Published: February 2022

There is a huge number of noncoding RNA (ncRNA) transcripts in the cell with important roles in modulation of different mechanisms. ANRIL is a long ncRNA with 3.8 kb length that is transcribed in the opposite direction of the INK4/ARF locus in chromosome 9p21. It was shown that polymorphisms within this locus are associated with vascular disorders, notably coronary artery disease (CAD), which is considered as a risk factor for life-threatening events like myocardial infarction and stroke. ANRIL is subjected to a variety of splicing patterns producing multiple isoforms. Linear isoforms could be further transformed into circular ones by back-splicing. ANRIL regulates genes in atherogenic network in a positive or negative manner. This regulation is implemented both locally and remotely. While CAD is known as a proliferative disorder and cell proliferation plays a crucial role in the progression of atherosclerosis, the functions of ANRIL and CAD development are intertwined remarkably. This makes ANRIL a suitable target for diagnostic, prognostic, and even therapeutic aims. In this review, we tried to present a comprehensive appraisal on different aspects of ANRIL including its location, structure, isoforms, expression, and functions. In each step, the contribution of ANRIL to atherosclerosis is discussed.
Classification Method of Aerobics Course Online Teaching Resources Based on Artificial Intelligence Technology
Authors: Zhao Hua , Zhang Xin , Wang Caixia , Yuan Weiyu
Published: February 2022

In light of the current uneven distribution of aerobics course online resources, this paper presents research on the classification method of aerobics course online teaching resources based on artificial intelligence technology, constructs the display education resource management system based on artificial intelligence technology, realizes the classification of teaching information characteristics, and constructs the classification and evaluation algorithm of aerobiology course online resources. The online teaching resource classification of aerobics course achieves its design goal. Finally, the experiment shows that the artificial intelligence-based online teaching resource classification method for aerobics course is highly practicable and fully meets the research requirements.
Effects of Dietary Sodium Acetate on Growth Performance, Fillet Quality, Plasma Biochemistry, and Immune Function of Juvenile Golden Pompano (Trachinotus ovatus)
Authors: Xun Pengwei , Zhou Chuanpeng , Huang Xiaolin , Huang Zhong , Yu Wei , Yang Yukai , Li Tao , Huang Jianbin , Wu Yang , Lin Heizhao
Published: February 2022

Six isonitrongenous and isolipidic diets were formulated to feed 360 fish (mean initial body weight:

6.06
±
0.02

 g) with graded levels of sodium acetate (SA1 (0), SA2 (250 mg/kg), SA3 (500 mg/kg), SA4 (1000 mg/kg), SA5 (2000 mg/kg), and SA6 (4000 mg/kg)) for 8 weeks. The results revealed that weight gain rate, specific growth rate, and feed intake of golden pompano were significantly increased in SA3 and SA4 treatments (

p
<
0.05

). Dietary SA level significantly improved lipid contents and gumminess of muscle (

p
<
0.05

). Supplement levels of dietary SA significantly influenced plasma biochemical parameters containing triglyceride, glucose, high-density lipoprotein cholesterol, complements, and immunoglobulin M (

p
<
0.05

). Appropriate supplement levels of dietary SA significantly increased enzyme activities of hepatic superoxide dismutase and total antioxidant capacity and decreased malondialdehyde contents (

p
<
0.05

). Furthermore, appropriate SA levels downregulated the expression levels of Keap1, IL-8, TNF-α, and NF-κB genes and upregulated the expression levels of Nrf2 and TGF-β genes of the spleen (

p
<
0.05

). Excess SA caused negative effects for Trachinotus ovatus. The optimum supplement level of SA for juvenile golden pompano was evaluated to be 1423.67 mg/kg based on WGR.
USMRI Features and Clinical Data-Based Model for Predicting the Degree of Placenta Accreta Spectrum Disorders and Developing Prediction Models
Authors: An Peng , Zhang Junyan , Yang Feng , Wang Zhongqiu , Hu Yan , Li Xiumei
Published: February 2022

Aim. This study aimed to investigate the ability of ultrasound/magnetic resonance imaging (MRI) signature and clinical data-based model for preoperatively predicting the degree of placenta accreta spectrum disorders and develop combined prediction models. Methods. The clinicopathological characteristics, prenatal ultrasound images, and MRI features of 132 pregnant women with placenta accreta spectrum disorders at Xiangyang No. 1 People’s Hospital were retrospectively reviewed from January 2016 to December 2020. In the training set of 99 patients, the ultrasound/MRI features model, clinical characteristics model, and combined model were developed by multivariate logistic regression analysis to predict the degree of placenta accreta spectrum disorders. The prediction performance of different models was compared using the Delong test. The developed models were validated by assessing their prediction performance in a test set of 33 patients. Results. The multivariate logistic regression analysis identified history of abortion, history of endometrial injury, and blurred boundary between the placenta and the myometrium/between the uterine serosa and the bladder to construct a combined model for predicting the degree of placenta accreta spectrum disorders (area under the curve (AUC) = 0.931; 95% confidence interval (CI): 0.882–0.980). The AUC of the clinical characteristics model and ultrasound/MRI features model was 0.858 (95% CI 0.794–0.921) and 0.709 (95% CI 0.624–0.798), respectively. The AUC of the combined model was significantly higher than that of the ultrasound/MRI features model

P
<
0.001

or clinical characteristics model

P
<
0.0015

in the training set. In the test set, the combined model also showed higher prediction performance. Conclusions. Ultrasound/MRI-based signature is a powerful predictor for the degree of placenta accreta spectrum disorders in an early stage. A combined model (constructed with history of abortion, history of endometrial injury, and blurred boundary between the placenta and the myometrium/between the uterine serosa and the bladder) can improve the accuracy for predicting the degree of placenta accreta spectrum disorders in an early stage.
Performance Analysis of Diode-Assisted Switched LC qZSI Network-Based Multioutput Series-Parallel Topologies in Microgrid Application
Authors: Sonkar Shri Prakash , Lal Vivek Nandan , Singh Rajeev Kumar
Published: February 2022

In this paper, two (series and parallel versions) quasi Z source inverter (qZSI)-based multioutput series-parallel topologies capable of supplying multiple three-phase AC and single boost DC outputs simultaneously are presented. The proposed parallel version topology can supply n number of AC outputs along with one boost DC with constant voltage and variable current. Similarly, the series version topology can give n number of AC including one boost DC output with constant current and variable voltage. The outputs of the proposed topologies can feed directly to DC/AC microgrids and multiple residential loads simultaneously without using any extra adapter/regulator and thereby avoiding local power conversion to meet the load demand. A hybrid pulse width modulation technique with constant frequency is used to operate the proposed topologies. The performance of the proposed topologies is verified by developing the prototypes of 2.18 kW (for parallel version) and 2.02 kW (for series version) for two three-phase AC outputs and one boost DC output. The developed prototypes show measured efficiency of 90.01% for the parallel and 89.95% for the series version topology.
A Characterization Study of the Patients Visiting Hospital due to Laryngopharyngeal Reflux Suspicion: A Prospective Case-Control Study
Authors: Chang Wei , Qiu Zhaofeng , Qin Jiangbo , Guo Xiaolin
Published: February 2022

Background: This study aimed to explore the characteristics of laryngopharyngeal reflux (LPR) and the association between LPR and allergic rhinitis (AR). Methods: In this prospective case-control study, a total of 102 patients with suspected LPR who visited the Department of Otolaryngology Head and Neck Surgery, Heping Hospital Affiliated to Changzhi Medical College, between June 2019 and June 2021 were consecutively included. They were divided into the LPR-positive group and the LPR-negative group according to 24-h Dx-pH monitoring. The influencing factors of LPR, including the scores for AR (SFAR) and AR prevalence, were compared between the two groups. Results: The total SFAR and scores in items 1, 3, 4, and 5 of the LPR-positive group were significantly higher than those of the LPR-negative group (p < 0.05). The prevalence of AR in the LPR-positive group was 60%, which was significantly higher than that in the LPR-negative group (36.54%) (p < 0.05). After excluding confounding factors, AR was positively correlated with the incidence of LPR, and the incidence of LPR with AR was 2.372 times that of non-AR. Receiver operating characteristic curve results show that AR has the highest predictive value for LPR, and the area of AR under the curve is was 0.617. Conclusions: The SFAR and incidence of AR are high in patients with positive LPR, and AR may be a risk factor for LPR. The results of this study may deepen our understanding of the occurrence of LPR.
An Anti-Interleukin-17A Monoclonal Antibody, Ixekizumab, in the Treatment of Resistant Hidradenitis Suppurativa: A Case Series
Authors: Esme Pelin , Botsali Aysenur , Akoglu Gulsen , Caliskan Ercan
Published: February 2022

Introduction: Although adalimumab is the only approved biologic for the treatment of hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients. Recently, many other biological agents, including interleukin 17 inhibitors such as ixekizumab, have shown promise. Case Presentations: Five severe HS (Hurley stage III) patients resistant to conventional treatments and adalimumab for at least 3 months were recruited. Patients were prescribed ixekizumab with a scheme approved for psoriasis (160 mg once, followed by 80 mg at weeks 2, 4, 6, 8, 10, and 12.) The primary outcome measure was achieving the Hidradenitis Suppurativa Clinical Response (HiSCR) score following 12 weeks. Secondary outcome measures included the patient-reported Dermatology Life Quality Index (DLQI) and visual analog scale (VAS). Four of 5 patients (80%) achieved HiSCR. While improvement was observed in the VAS and DLQI scores of 4 patients, the decline was limited in 1 patient. No adverse event was recorded related to ixekizumab. Conclusion: The result of our observation suggests that ixekizumab may be effective for HS, especially in challenging cases.
Geriatrische Pneumologie: Individualisiertes Medikamentenmanagement implementieren
Authors: Frohnhofen Helmut
Published: February 2022

Background: An aging society is frequently affected by multimorbidity and polypharmacy, which, in turn, leads to an increased risk for drug interaction. The aim of this study was to evaluate the influence of drug interactions on the length of stay (LOS) in hospitals. Methods: This retrospective, single-centre study is based on patients treated for community-acquired pneumonia in the hospital. Negative binomial regression was used to analyse the association between drug interactions and the LOS in the hospital. Results: The total cohort contained 503 patients, yet 46 inpatients (9%) that died were not included in the analyses. The mean age was 74 (±15.3) years, 35% of patients older than 65 years were found to have more than two drug interactions, and 55% had a moderate, severe, or contraindicated adverse drug reaction. The regression model revealed a significant association between the number of drug interactions (rate ratio (RR) 1.02; 95%-CI 1.01–1.04) and the severity of drug interactions (RR 1.22; 95%-CI 1.09–1.37) on the LOS for the overall cohort as well as for the subgroup of patients aged 80 years and older. Conclusion: Drug interactions are an independent risk factor for prolonged hospitalisation. Standardised assessment tools to avoid drug interactions should be implemented in clinical routines.
Correlation between Serum Cystatin C Level and Retinal Blood Flow in Patients with Essential Hypertension
Authors: Huang Sumin , Zhang Shu , Wang Jiajun , Hou Guanghui , Xu Shuyi
Published: February 2022

Introduction: Hypertension is known to impact the structure and function of the ocular vascular system and is an established risk factor for many eye diseases. This study aimed to detect the blood flow in the optic disc and macula in patients with essential hypertension and to analyze its correlation with serum cystatin C (Cys-C) levels. Methods: This single center, cross-sectional study included 100 patients with primary hypertension without hypertensive retinopathy, who were divided into an experimental group (50 cases, 50 eyes) with elevated serum Cys-C levels and a control group (50 cases, 50 eyes) with normal serum Cys-C. The optic disc and macular vessel density (VD) and vascular perfusion density (PD) were assessed using optical coherence tomography angiography. Data such as the area, perimeter, and circularity of the foveal avascular zone (FAZ) were analyzed. Results: There were statistically significant between-group differences in the VD and PD of the optic disc (p < 0.05). Spearman correlation analysis of related indicators revealed that serum Cys-C was positively correlated with creatinine, uric acid, and FAZ circularity (p < 0.05). Furthermore, serum Cys-C was negatively correlated with optic disc VD and PD in some regions (p < 0.05). Conclusion: In patients with essential hypertension, serum Cys-C is negatively correlated with VD and PD in the inner layer of the optic disc (zone 10).
Acute Adnexal Torsion: Is Immediate Surgical Intervention Associated with a Better Outcome?
Authors: Yaakov Odelia , Ashwal Eran , Gemer Ofer , Peled Yoav , Kapustian Victoria , Namazov Ahmet , Eitan Ram , Krissi Haim
Published: February 2022

Objectives: We aimed to investigate whether surgery for adnexal detorsion within 6 h from admission to the hospital was associated with less adnexal ischemia. Design: This is a retrospective cohort study. Participants/Materials, Setting, and Methods: This retrospective study was conducted at two university-affiliated medical centers and assessed women aged 18–45 years with adnexal torsion who were hospitalized within 12 h from the pain onset and underwent surgery for detorsion within 24 h. The study group was divided into 2 groups: early, surgical intervention within less than 6 h and late, surgical intervention between 6 and 24 h. The primary outcome was the rate of macroscopic appearance of ischemic adnexa. Results: Two hundred and twenty women fulfilled the inclusion criteria. In 101 women, the adnexa with the torsion appeared macroscopically ischemic. There was no difference in ischemic adnexa between the early and late intervention groups (48% vs. 40%; p = 0.269). No significant association was found between the physical examination or ultrasonographic findings and the rate of ischemic adnexa within each group. Limitations: The main limitations of our study are its retrospective nature. Much of the clinical and ultrasonographic data are subjective and operator-dependent. The decision to operate may vary from one surgeon to another. Conclusion: Immediate surgical intervention in patients with adnexal torsion is not associated with a lower rate of adnexal ischemia. These findings suggest that in acute adnexal torsion, there is a wider time window for a thorough evaluation before surgery.
Topical Rosmarinus officinalis L. in Systemic Sclerosis-Related Raynaud’s Phenomenon: An Open-Label Pilot Study
Authors: Vagedes Jan , Henes Jörg , Deckers Bernhard , Vagedes Katrin , Kuderer Silja , Helmert Eduard , von Schoen-Angerer Tido
Published: February 2022

Background: An effective and well-tolerated topical treatment of Raynaud’s phenomenon is needed. The aim of this pilot study was to determine change in skin temperature and self-reported warmth perception from topical rosemary essential oil in patients with systemic sclerosis and secondary Raynaud’s phenomenon. Patients and Methods: Twelve patients with progressive systemic sclerosis and Raynaud’s phenomenon were consecutively enrolled in an open-label pilot study at a university outpatient rheumatology clinic. Each patient received an application of olive oil to both hands as a control and 3 h later an application of a 10% essential oil of Rosmarinus officinalis L. Clinical severity and subjective warmth perception were assessed; skin temperature was measured by infrared thermography. Results: Skin temperature increased significantly after both olive oil and rosemary oil but differences between oils did not reach significance. Self-reported warmth perception increased after rosemary oil but not after olive oil. No adverse effects were observed. Conclusion: Topical rosemary essential oil increased warmth perception in patients with systemic sclerosis-related Raynaud’s phenomenon but did not increase finger skin temperature more than the olive oil control.
Sobre o populismo no Brasil
Authors: Chaui Marilena
Published: February 2022

Com a ideia de invenção democrática, Claude Lefort recriou o conceito moderno de democracia, retomando num contexto novo a ideia de Moses Finley de invenção da política, para indicar uma ação que se realiza sem o apoio de modelos, e, no caso de Lefort, para marcar a recusa de fundamentos externos ao social. Para pensar a experiência política do presente, escreve ele, é preciso afastar, de um lado, a redução marxista da política à condição de superestrutura, e, de outro, a concepção liberal da democracia como regime político da lei e da ordem para assegurar liberdades individuais; e, não menos importante, também afastar as ciências sociais, particularmente a sociologia e a ciência política, que buscam seu objeto a partir da construção ou delimitação do “fato político”, considerado um fato particular ao lado de outros fatos sociais particulares (econômico, jurídico, científico, estético, ou simplesmente social, isto é, como modo de relação entre grupos e classes).
Apresentação da tradução de "Narciso, ou o amante de si mesmo"
Authors: Babiuki Kamila C. , Leite Rafael de Araújo e Viana
Published: February 2022

Apresentação da tradução de "Narciso, ou o amante de si mesmo", comédia em um ato escrita por Jean-Jacques Rousseau.
processo maquínico primitivo: Pierre Clastres em "Mil platôs"
Authors: Fornazari Sandro Kobol
Published: February 2022

Partindo da apresentação das principais teses da etnologia de Pierre Clastres, onde se desenvolve o tema da máquina de guerra primitiva, o artigo procura analisar a influência desse pensamento em Mil platôs, de Deleuze e Guattari, mostrando de que modo eles abordam a recusa do evolucionismo para determinar o surgimento do Estado, preocupação presente também em Clastres. Mas, essa influência se faz presente sobretudo na definição do conceito de processo maquínico das sociedades primitivas a partir do mecanismo de conjuração-antecipação.
"American Nigthmare: Facing the Challenge of Fascism", de Henry Giroux
Authors: Carneiro Silvio Ricardo Gomes
Published: February 2022

Resenha do livro AMERICAN NIGHTMARE: FACING THE CHALLENGE OF FASCISM, DE HENRY GIROUX
simpatia em Hume: entre o Tratado, o caráter nacional e as facções.
Authors: Galvão Dario
Published: February 2022

O presente texto procura percorrer o Tratado da natureza humana (1739-40) e alguns dos Ensaios morais, políticos e literários tendo como fio condutor o princípio da simpatia em Hume. A partir da enunciação do princípio no Livro II do Tratado, seguimos em especial aos ensaios “Dos caráteres nacionais” (1748) e “Dos partidos em geral” (1741). Sob essa perspectiva, espera-se observar como a simpatia e, por conseguinte, a imaginação podem ser relevantes para compreender como se articula o pensamento político e social na filosofia humeana.
Gastos Federais com Acesso e Repartição de Benefícios da Biodiversidade no Brasil (2001-2020)
Authors: Tozato Heloisa de Camargo , Novion Henry , Roma Júlio , Luedemann Gustavo , Coelho Luísa
Published: February 2022

A agenda brasileira de Acesso e Repartição de Benefícios do uso do patrimônio genético e dos conhecimentos tradicionais associados (agenda ABS) caracteriza-se como uma política pública de integração entre a conservação da biodiversidade, o desenvolvimento e a inclusão da sociedade. O presente artigo teve como objetivo analisar os gastos orçamentários de 20 anos de sua implementação no país (2001 a 2020). A análise foi realizada a partir da consulta aos documentos oficiais de orçamento, de planejamento e de relato da gestão, e complementada com a contribuição de atores-chave. Os resultados revelam que o país investiu R$ 2,3 milhões ao ano para a agenda ABS e que foram repartidos benefícios monetários e não monetários da ordem de quase R$ 24 milhões, isto é, mais de 51% dos gastos orçamentários executados pelo Ministério do Meio Ambiente. O estudo contribui com a análise do Componente 5 da Política Nacional de Biodiversidade e provoca a reflexão sobre a importância da elaboração da avaliação de impacto da agenda ABS no país.
Social Context and Rejection Expectations Modulate Neural and Behavioral Responses to Social Feedback
Authors: Petereit Pauline , Jessen Sarah , Goregliad Fjaellingsdal Tatiana , Krämer Ulrike M.
Published: February 2022

When meeting other people, some are optimistic and expect to be accepted by others, whereas others are pessimistic and expect mostly rejections. How social feedback is evaluated in situations that meet or do not meet these biases and how people differ in their response to rejection and acceptance depending on the social situation are unknown. In this study, participants experienced rejection and acceptance by peers in two different social contexts, one with high (negative context) and the other with low probability of rejection (positive context). We examined how the neural and behavioral responses to rejection are altered by this context and whether it depends on the individual's sensitivity to rejection. Behavioral results show that, on average, people maintain an optimistic bias even when mostly experiencing rejection. Importantly, personality differences in rejection sensitivity affected both prior expectations to be rejected in the paradigm and the extent to which expectations changed during the paradigm. The context also strongly modulated ERPs and theta responses to rejection and acceptance feedback. Specifically, valence effects on neural responses were enhanced in the negative context, suggesting a greater relevance to monitor social feedback in such a situation. Moreover, midfrontal theta predicted how expectations were changed in response to prediction errors, stressing a role for theta in learning from social feedback. Surprisingly, interindividual differences in rejection sensitivity did not affect neural responses to feedback. Our results stress the importance of considering the interaction between subjective expectations and the social context for behavioral and neural responses to social rejection.
Anecdotal observations of ‘double clutching’ behaviour in captive Mugger crocodiles (Crocodylus palustris)
Authors: Desai Brinky , Mukherjee Soham , Whitaker Nikhil , Ghosal Ratna
Published: February 2022

Animals modulate their behaviours in accordance with their local environment and in the process, undergo different behavioural and physiological adaptations to better survive in a given ecosystem. One such behaviour that plays an important role in survival and sustenance of a species is the breeding behaviour. In this article, we present anecdotal information on breeding strategies of Marsh or Mugger crocodiles. Mugger crocodiles mostly lay single clutch during a year and have an elongated courtship and mating period lasting for 3–4 months. However, we show anecdotal data covering a period of 2 years for a Mugger crocodile producing double clutches annually under captive conditions. The laying of multiple clutches in captive Mugger crocodiles may indicate higher nutritional status and/or breeding strategies of the females under resourceful conditions. We suggest the need for future work on understanding proximate mechanisms underlying the ‘double clutching’ behaviour of Mugger crocodiles.
Awakening the Intuitive Mind: Self-Cultivation in the Practical Philosophies of Wang Yangming and Sri Aurobindo
Authors: Hartz Richard
Published: February 2022

Sri Aurobindo lived four hundred years after Wang Yangming in a different civilization and another age. Yet there are parallels between the lives of these two thinkers and significant similarities between their philosophies. Central to the methods of practice advocated by both is the uncovering of a faculty of knowledge which we already possess, but normally allow to be obscured by our ordinary psychological movements. This faculty, the intuitive mind, has to emerge and be applied to all the activities of life. Methods for cultivating it have been developed under different names in both China and India. They can be found in ancient texts such as the Great Learning and the Bhagavadgītā as well as in the writings of Wang Yangming and Sri Aurobindo. Integral education would be incomplete if it does not include the cultivation of the intuitive mind.
Participatory Drama: A Pedagogy for Integrating Language Learning and Moral Development
Authors: Winston Joe
Published: February 2022

This paper illustrates how integral drama-based pedagogy can be effective in two areas of learning for primary aged children, namely in language development and moral thinking. The activities that demonstrate how the theory can be put into practice are based upon a picture book and show how storytelling and aesthetic playfulness lie at the heart of the process. I argue that the processes used in the pedagogy as much as the content of the lesson itself contribute to children’s ethical cultivation, while the story around which the activities are framed draw out from children vocabulary that builds upon and extends what they intrinsically know about how humans ought to treat one another. Each of the activities is thoroughly described so that teachers who are unused to the demands of this pedagogy can see exactly how it can be managed and made to work in the classroom.
A new species of Echinoderes (Kinorhyncha: Cyclorhagida: Echinoderidae) from the Argentinean continental shelf with notes on its postembryonic development and on subcuticular morphological characters unreported for Kinorhyncha
Authors: RUCCI KEVIN A. , NEUHAUS BIRGER , BULNES VERÓNICA N.
Published: February 2022

Echinoderes goku sp. nov. is described from adult and juvenile specimens in samples collected from the Argentinean continental shelf in March 2019 during the campaign of the Motorsailer “Bernardo Houssay”, based on light and scanning electron microscopy studies. Echinoderes goku sp. nov. is differentiated from other species by its unique spine and tube pattern: (1) middorsal spine on segments 4, 6, and 8, (2) spine in lateroventral position on segments 6–9, (3) tube present in subdorsal position on segment 2, sublateral to midlateral position on segments 7 and 9, lateral accessory position on segment 8, lateroventral position on segment 5 and ventrolateral position on segment 2. Additionally, this species (4) lacks type-2 gland cell outlets and female-specific papillae or subcuticular funnel-like structures. (5) The male possesses a sublateral tube on segment 10 with a basal cylindrical reinforcement structure and three penile spines on segment 11, whereas the female lacks penile spines but reveals a lateral terminal accessory spine on segment 11 and on segment 10 lacks a subdorsal tube but possesses instead a sublateral fringe on the surface connected with a subcuticular conical structure and a basal cylindrical reinforcement structure. Among several juvenile specimens, one was captured in the process of moulting from the last juvenile stage to the female. Whereas the last juvenile stage revealed a sublateral tube on segment 10, the moulting female lacked this tube and showed a conical subcuticular structure with a basal cylindrical reinforcement structure instead. A cylindrical reinforcement structure at the base of a tube and a subcuticular conical structure have not been reported before for Kinorhyncha, and 14 selected species of Echinoderidae available for study were screened for these characters in order to get a first idea of their possible taxonomic importance. This article reports about the second species of Echinoderes from Argentinean waters.
Application of Entomopathogenic Nematodes/Metal Organic Frameworks/Sodium Alginate Composite Microspheres in the Control of Termites
Authors: Chen Xiaobei , Li Xiaolong , Zhang Fengqin
Published: February 2022

In order to provide scientific basis for control of termites, the control of termites using entomopathogenic nematodes/Metal organic Frameworks/sodium alginate composite microspheres was herein studied. Firstly, four MOFs with antibacterial properties, MOF-199, ZIF-67, MOF-5 and ZIF-8,
were synthesized, and then entomopathogenic nematodes/MOFs/sodium alginate composite microspheres were prepared. Under laboratory culture conditions, the survival rate of nematodes in the particles and mortality rate against termites were determined. Entomopathogenic nematodes/MOFs/sodium
alginate composite microspheres were found to have good antibacterial properties, which can prolong the action time for the particles. MOFs had no adverse effect on survival rate of nematodes, and the lethal effect of MOFs on termites reached up to 85%. We can safely draw the conclusion that
the entomopathogenic nematodes/MOFs/sodium alginate composite microspheres can effectively trap and kill termites. This study will provide a new idea for development of biological insecticides and control of termites.
Regulation Mode of RaMYB1 of Ranunculus asiaticus L. in Anthocyanin Biosynthesis Responding to Temperature Decrease
Authors: Liu Yanfang , Yang Xiaohong , Huang Qingmei , Qiao Juxiang , Yang Xuhong
Published: February 2022

Color is of great importance for the testing and breeding of plant varieties, and is known to be varied along with temperature changes. However, at the transcription level, the exact binding sites and corresponding regulation properties in the pathway of anthocyaninn biosynthesis in
vivo are rarely reported. In this study, variety ‘Doppio Pandora-purple’ of Ranunculus asiaticus L. whose flower color is sensitive to the decrease in temperature was used. In the results, 27 genes involved in anthocyanin biosynthesis were differentially expressed under
cold stress, and 7 MYB genes were up-regulated; the most obviously up-regulated MYB (RaMYB1) gene belongs to R2R3-MYB type. Promoter sequences of the 27 genes were concluded from transcriptome sequences and genome walking, for the purpose of sequence alignment with ChIP-seq/DAP-seq sequences.
7 genes were determined as target genes of RaMYB1 in cold-induced transcription regulation, including 2 PAL (phenylalanine ammonia lyase), 2 CHS (chalcone synthase), 1 F3H (flavanone 3-hydroxylase), 1 DFR (dihydroflavonol 4-reductase), 1 F3’H (flavanoid
3’-hydroxylase). ChIP-PCR indicated that, the binding of RaMYB1 to DFR can be induced by temperature decrease, while the bindings to other 6 genes were constitutive and can be strengthened at 5 °C decrease. Regulation properties of RaMYB1 to the 7 genes were determined as
enhancement due to their up-regulation as well as the enhancer in C terminal of RaMYB1. Regulation mode of RaMYB1 was mapped accordingly and validated via HPLC-based anthocyanin content, gene expression level and coloration. The regulation mode can illustrate the binding sites and enhancement
property of RaMYB1 in the regulation of anthocyanin biosynthesis under cold stress. It can be applied in color-oriented temperature monitoring and in molecular breeding. The way to establishing the regulation mode may be interest for other non-model plant genera with little molecular background.
International Business Machinations: A Case Study of Corporate Involvement in Local Educational Reform
Authors: Mickelson Roslyn Arlin
Published: February 2022

This article examines several education reform programs supported by one corporation, IBM, in one community, Charlotte, North Carolina. By tracing how these initiatives were developed and implemented, we gain insights into the implications for educational equity and quality of intimate corporate sponsorship and direction of school restructuring. The case study of IBM in Charlotte highlights both the opportunities for and dangers of corporate philanthropy and educational reform leadership.
Underlying Policy Assumptions of Charter School Reform: The Multiple Meanings of a Movement
Authors: Wells Amy Stuart , Grutzik Cynthia , Carnochan Sibyll , Slayton Julie , Vasudeva Ash
Published: February 2022

Based on interviews with more than 50 policy makers in six states, this article examines the politics of charter school reform and argues that the bipartisan support for these more autonomous schools masks often opposing viewpoints regarding the purpose of this reform. The authors identify three salient and conflicting themes that emerge from policy makers’ explanations of their support for charter schools. The first theme was voiced by policy makers who see charter schools as the beginning of the end of government-run public education and the forefront of a move toward vouchers. The second theme was articulated by policy makers who are committed to a system of public education, but who see charter school reform as a “last chance” to save that system. And the third theme arose in interviews with policy makers who see charter schools as one of many, but not necessarily the central, reform that could strengthen the public schools. Thus, the authors write that charter school reform embodies less of a consensus of views about the future of public education than a fragile bargain between political adversaries who all seek to prove they favor educational reform, but for different reasons and toward different ends.
Teaching in Tensions: Latino Immigrant Youth, Their Teachers, and the Structures of Schooling
Authors: Katz Susan Roberta
Published: February 2022

This article examines the tensions inherent in the relationship between Latino immigrant youth and their teachers at a desegregated urban middle school in Northern California, exploring these tensions from both the students’ and teachers’ perspectives. It is based upon data from a year-long ethnographic study of the school experiences of eight immigrant students from Central America and Mexico, all of whom had older siblings or close friends involved in neighborhood gangs. It also includes interviews with the students’ teachers regarding their perceptions of the students. Significantly, students named teachers’ discrimination against them as Latinos as the primary cause of their disengagement from school, refusing to invest in learning from these teachers. At the same time, these teachers felt they were trying their best to do a good job, responding to the school administration's mandate to invest in other students who were considered most likely to keep standardized test scores high. Thus this article explores how teachers’ attitudes and practices perceived by students as racist may be actually linked to structural conditions within the school, such as tracking and high teacher turnover, that preclude caring relationships with students.