bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of work-family conflict on job satisfaction and job stress: Mediation model from Indonesia
Authors: Siswanto  , Masyhuri  , Hidayati Nur , Ridwan Muhtadi , Hanif Rifki
Published: April 2022

This paper analyzes the impact of work-family conflict on employees’ job satisfaction and job stress and determines how organizational commitment and social support reduce job satisfaction and job stress. The study employed a questionnaire to collect the data from 382 Islamic bank employees in Indonesia. After the data were collected, it was calculated using SEM-PLS. The results showed that work-family conflict was a significant predictor of job satisfaction and job stress. Furthermore, social support mediates the influence of work-family conflict on job stress. However, organizational commitment is not able to mediate the two variables. Practically, the results of this study indicate that bank employees have high work stress due to role conflicts that occur in their families. In addition, one of the causes of role conflicts is the government’s policy to work from home during the pandemic. Furthermore, social support can mediate the relationship between work-family conflict and job stress, meaning that social support can help employees reduce job stress due to role conflicts in their families. Therefore, companies must pay attention to the psychological condition of employees before giving assignments.
Pavonia Cav. SPECIES (MALVACEAE SENSU LATO) AS SOURCE OF NEW DRUGS: A REVIEW
Authors: Albuquerque Janderson , Silva Camila , Fernandes Diégina , Souza Pedro , Souza Maria
Published: April 2022

Pavonia Cav., is a genus in the Malvaceae sensu lato family, containing 271 species with worldwide distribution, although with a higher diversity in America and Asia. Species from this genus are traditionally used in folk medicine with several biological activities, arousing scientific interest on the search for the substances responsible for such activities. This review aimed to provide and expand the scientific interest through phytochemical and pharmacological studies and the utilization of those plants in folk medicine. Species P. odorata and P. zeylanica are described in literature, specially at India, following the traditional medicine system Ayuverda, while the other species are studied mostly at Africa and America. There have been around 169 compounds isolated and characterized for such genus, most of them from the metabolic classes fat acids, terpenoids, flavonoids and phenolic compounds. Those species have shown in vivo, in vitro and in silico significant pharmacological activities, which include anti-inflammatory, analgesic, antimicrobial, cytotoxic, antitumoral, antidiabetic and antioxidant properties. Based on those informations, the search for new sources of plant based biologic prototypes with potential for the treatment of several diseases is of major scientific, economical and medicinal interest.
Determination of mercury concentration by a new spectrophotometric method and evaluation of bacterial diversity in river water samples from Brazil
Authors: Simião Daniela Carolina , de Andrade Frank Pereira , Lima William Gustavo , de Jesus Maria Larissa , Dorim Pedro Henrique Gomes , Paiva Magna Cristina
Published: April 2022

One of the main micropollutants reported in river water is mercury (Hg), a heavy metal toxic to human and animal organisms that can promote bacterial resistance to antimicrobials used in the clinical practice. Having done this in consideration, monitoring the concentration of Hg in the river is an important indicator of physical-chemical and microbiological quality of water. Thus, in this study, the Hg concentration was determined using a new spectrophotometric method in river water samples recovered from Minas Gerais, Brazil. Furthermore, the diversity and antimicrobial resistance of Gram-positive and Gram-negative bacteria isolated from these samples were also reported. A new ultraviolet-visible spectrophotometric method was validated and applied to quantify Hg in water and revealed high concentrations in the samples (0.13–0.35 μg·mL−1), above the limits established by Brazilian standards (0.002 μg·mL−1). Gram-negative bacteria (mainly Escherichia coli) were recovered in greater proportion (88.4%) from water samples with high mercury concentration and showed resistance to tetracycline and ampicillin. Our results highlighted that E. coli resistant to carbapenems, which are latest generation beta-lactams, were detected. In conclusion, the Hg levels are considerably high in river waters in Brazil, and these mercury-rich water sources are important reservoirs of multi-drug resistant bacteria.
Sample Processing Considerations for Protein Stability Studies of Low
Concentration Biofluid Samples using Differential Scanning Calorimetry
Authors: Schneider Gabriela , Garbett Nichola C.
Published: April 2022

Background:

The analysis of biofluid samples with low protein content (e.g., urine or
saliva) can be challenging for downstream analysis methods with limited sensitivity. To circumvent
this problem, sample processing methods are employed to increase the protein concentration in
analyzed samples. However, for some techniques, like differential scanning calorimetry (DSC) that
characterizes thermally-induced unfolding of biomolecules, sample processing must not affect
native protein structure and stability.

Methods:

We evaluated centrifugal concentration and stirred cell ultrafiltration, two common
methods of sample concentration characterized by a low risk of protein denaturation, with the goal
of establishing a protocol for DSC analysis of low concentration biospecimens.

Results:

Our studies indicate that both methods can affect protein stability assessed by DSC and,
even after optimization of several parameters, the obtained DSC profile (thermogram) suggested
that sample processing affects the structure or intermolecular interactions of component proteins
contributing to altered thermal stability detectable by DSC. We also found a relationship between
changes in thermograms and low protein concentration, indicating that diluting biospecimens to
concentrations below 0.1 mg/mL can perturb the intermolecular environment and affect the
structure of proteins present in the solution.

Conclusions:

Dilution of samples below 0.1 mg/mL, as well as concentration of samples with low
protein content, resulted in affected thermogram shapes suggesting changes in protein stability. This
should be taken into account when concentrating dilute samples or employing techniques that lower
the protein concentration (e.g., fractionation), when downstream applications include techniques,
such as DSC, that require the preservation of native protein forms.
Translocator Protein 18-kDa: A Promising Target to Treat Neuroinflammation-
related Degenerative Diseases
Authors: Tremolanti Chiara , Germelli Lorenzo , Barresi Elisabetta , Da Pozzo Eleonora , Simorini Francesca , Castellano Sabrina , Taliani Sabrina , Da Settimo Federico , Martini Claudia , Costa Barbara
Published: April 2022

In the nervous system, inflammatory responses physiologically occur as defense
mechanisms triggered by damaging events. If improperly regulated, neuroinflammation can
contribute to the development of chronically activated states of glial cells, with the perpetuation
of inflammation and neuronal damage, thus leading to neurological and neurodegenerative
disorders. Interestingly, neuroinflammation is associated with the overexpression of the
mitochondrial translocator protein (TSPO) in activated glia. Despite the precise role of
TSPO in the immunomodulatory mechanisms during active disease states is still unclear, it
has emerged as a promising target to promote neuroprotection. Indeed, TSPO ligands have
been shown to exert beneficial effects in counteracting neuroinflammation and neuronal
damage in several in vitro and in vivo models of neurodegenerative diseases. In particular,
the regulation of neurosteroids’ production, cytokine release, metabolism of radical oxidative
species, and cellular bioenergetics appear to be the main cellular events that underlie the
observed effects. The present review aims to illustrate and summarize recent findings on the
potential effect of TSPO ligands against neuroinflammation and related neurodegenerative
mechanisms, taking into consideration some pathologies of the nervous system in which inflammatory
events are crucial for the onset and progression of the disease and attempting to
shed light onto the immunomodulatory effects of TSPO.
Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles
and Its Mechanism
Authors: Malik Zoya , Parveen Rabea , Abass Sageer , Irfan Dar Mohammad , Husain Syed Akhtar , Ahmad Sayeed
Published: April 2022

Nanoparticles have gained prominence in many areas and domains worldwide, such as metallic NP, carbon
dots, quantum dots, polymeric NP, nano-suspension, nanocrystals, solid lipid nanoparticles (SLN), etc. and have
been applied in the field of medicine as nanomedicine with promising results. Rise in cancer mortality rate has been
an issue for a long time with female breast cancer as one of the most detected cancers. No permanent treatment has
been developed till date could combat breast cancer with minimum side effects that are not long-lasting as there is no
proper technique through which the anticancer drugs can recognize benign or malignant or normal cells that causes
systematic toxicity. Advancement in technology has led to the discovery of many biological pathways and mechanisms.
Tumor cells or cancer cells overexpress some high-affinity receptors that can be targeted to deliver the anticancer
drugs at specific site using these pathways and mechanisms. Solid lipid nanoparticles (SLN) are among some
of the excellent drug delivery systems, especially stealth SLN (sSLN). SLN, when conjugated with a ligand (called as
sSLN), has affinity and specificity towards a specific receptor, and can deliver the drug in breast cancer cells overexpressing
the receptors. Using this technique, various investigations have reported better anti-breast cancer activity
than simple SLN (non-conjugated to ligand or no receptor targeting). This review includes the investigations and data
on receptor-mediated targeting in breast cancer from 2010 to 2021 by searching different databases. Overall, information
on SLN in different cancers is reviewed. In vivo investigations, pharmacokinetics, biodistribution, and stability
are discussed to describe the efficacy of sSLN. Investigations included in this review demonstrate that sSLN
delivers the drug by overcoming the biological barriers and shows enhanced and better activity than non-conjugated
SLN which also verifies that a lesser concentration of drug can show anti-breast cancer activity. The efficacy of
medicines could be increased with lower cancer deaths through stealth-SLN. Due to the low cost of synthesis, biocompatibility
and easy to formulate, more study is needed in vitro and in vivo so that this novel technique could be
utilized in the treatment of human breast cancer.
An Overview of Treatment Guidelines and Methods of Synthesis of Drugs
Used in Leprosy Chemotherapy
Authors: Pinheiro Luiz C.S. , Borges Julio C. , Campos Vinicius R. , Dantas Leonardo C.
Published: April 2022

Leprosy is a Neglected Tropical Disease (NTDs) caused by Mycobacterium leprae (M.
leprae). The treatment is considered effective, however, the high dose Multidrug Therapy (MDT)
for a long period and its adverse effects result in the abandonment of the treatment by patients.
Indeed, antimicrobial resistance is still an obstacle that must be overcome in the treatment of leprosy.
In the present article, we reviewed the WHO guidelines for the chemotherapy of leprosy and
the methods of synthesis of these drugs.
Regulating the Size of Simvastatin-loaded Discoidal Reconstituted Highdensity
Lipoprotein: Preparation, Characterization, and Investigation of
Cellular Cholesterol Efflux
Authors: Zhang Wenli , Liu Jianping , Huang Xinya , Gao Hai , Zhang Qiqi
Published: April 2022

Background:

Reverse cholesterol transportation is essential for high-density lipoprotein
(HDL) particles to reduce the cholesterol burden of peripheral cells. Studies have shown that particle
size plays a crucial role in the cholesterol efflux capacity of HDLs, and the reconstituted HDLs
(rHDLs) possess a similar function to natural ones.

Ojective:

The study aimed to investigate the effect of particle size on the cholesterol efflux capacity of
discoidal rHDLs and whether drug loadings may have an influence on this effect.

Methods:

Different-sized simvastatin-loaded discoidal rHDLs (ST-d-rHDLs) resembling nascent HDL
were prepared by optimizing key factors related to the sodium cholate of film dispersion-sodium cholate
dialysis method with a single controlling factor. Their physicochemical properties, such as particle
size, zeta potential, and morphology in vitro, were characterized, and their capacity of cellular cholesterol
efflux in foam cells was evaluated.

Results:

We successfully constructed discoidal ST-d-rHDLs with different sizes (13.4 ± 1.4 nm, 36.6 ±
2.6 nm, and 68.6 ± 3.8 nm) with over 80% of encapsulation efficiency and sustained drug release.
Among them, the small-sized ST-d-rHDL showed the strongest cholesterol efflux capacity and inhibitory
effect on intracellular lipid deposition in foam cells. In addition, the results showed that the loaded
drug did not compromise the cellular cholesterol efflux capacity of different-sized ST-d-rHDL.

Conclusion:

Compared to the larger-sized ST-d-rHDLs, the small-sized ST-d-rHDL possessed enhanced
cellular cholesterol efflux capacity similar to drug-free one, and the effect of particle size on
cholesterol efflux was not influenced by the drug loading.
Clinical and Molecular Findings in a Turkish Family Who Had a (c.869-
1G>A) Splicing Variant in PSEN1 Gene with A Rare Condition: The Variant
Alzheimer's Disease with Spastic Paraparesis
Authors: Doğan Mustafa , Eröz Recep , Tecellioğlu Mehmet , Gezdirici Alper , Çevik Betül , Barış İbrahim
Published: April 2022

Background:

Early-onset Alzheimer's disease (EOAD) is commonly diagnosed with an onset
age of earlier than 65 years and accounts for 5–10% of all Alzheimer's disease (AD) cases. To date,
although only 10-15% of familial EOAD cases have been explained, the genetic cause of the vast proportion
of cases has not been explained. The variant Alzheimer's disease with spastic paraparesis (var-
AD) is defined as a rare clinical entity characterized by early-onset dementia, spasticity of the lower extremities,
and gait disturbance. Although the disease was first associated with variants in exon 9 of the
PSEN1 gene, it was later shown that variations in other exons were also responsible for the disease.

Objective:

The current study aims to raise awareness of varAD, which occurs as a rare phenotype due to
pathogenic variants in PSEN1. In addition, we aimed to evaluate the spectrum of mutations in varAD
patients identified to date.

Methods:

Detailed family histories and clinical data were recorded. Whole exome sequencing was performed
and co-segregation analysis of the family was done by Sanger sequencing. Also, a review of the
molecularly confirmed patients with (varAD) from the literature was evaluated.

Results:

We identified a heterozygous splicing variant (c.869-1G>A) in the PSEN1 gene, in a family
with two affected individuals who present with varAD. We reported the clinical and genetic findings
from the affected individuals.

Conclusion:

We present the detailed clinical and genetic profiles of a Turkish patient with the diagnosis
of varAD together with subjects from the literature. Together, we think that the clinical characteristics
and the effect of the (c.869-1G>A) variant will facilitate our understanding of the PSEN1 gene in AD
pathogenesis.
Usefulness of Lipidic Nanoparticles of Curcumin and Tetrahydrocurcumin
for Skin Inflammation: A Comparative Study
Authors: Saini Komal , Verma Manoj Kumar , Kaur Indu Pal , Kakkar Vandita
Published: April 2022

Background:

Yellow curcumin, the “Indian Gold” is known since ancient times to modulate the activities of a wide variety of targets. The voluminous literature and several patents are a proof of the therapeutic value of curcumin. Tetrahydrocurcumin (THC), however, has remained as an unexplored molecule although its cosmeceutical properties have been documented. Their compromised bioavailability, poor aqueous solubility (curcumin 11 ng/mL, THC 56ng/mL), high log P (Cur: 3.28; THC: 2.98) are hurdles for developing as potential drugs.

Objective:

This article discusses the usefulness of lipidic nanoparticles of curcumin and THC for skin inflammation.

Method:

Nanocouturing to produce lipidic nanoparticles (LNs) of curcumin and THC was done via an optimized microemulsification technique. LNs were characterized by FTIR, TEM, pharmacokinetics, and pharmacodynamic study.

Results:

FTIR reflected the suitable incorporation of drugs into LNs. TEM examination revealed a spherical to ellipsoidal shape with a particle size of <200 nm. In vitro release study indicates the release of both drugs is between 70-80% within 24 h. Ex-vivo permeation studies confirmed the ability of LNs to cross the stratum corneum. Stability studies (Q1AR2) indicated that both were stable, safe, and nonirritating (OECD 404). Xylene induced ear edema model of inflammation showed both molecules to possess equivalent abilities to treat inflammation.

Conclusion:

Curcumin being yellow in color is unstable at physiological pH and plasma and possesses poor bioavailability, while THC is a colorless stable molecule, making it a molecule of choice to be developed as an effective topical product.
Biodegradable Nanogels for Dermal Applications: An Insight
Authors: Kesharwani Payal , Prajapati Shiv Kumar , Jain Anushka , Sharma Swapnil , Mody Nishi , Jain Ankit
Published: April 2022

Biodegradable nanogels in the biomedical field are emerging vehicles comprising
dispersions of hydrogel nanoparticles having 3D crosslinked polymeric networks. Nanogels show
distinguished characteristics including their homogeneity, adjustable size, low toxicity, stability
in serum, stimuli-responsiveness (pH, temperature, enzymes, light, etc.), and relatively good
drug encapsulation capability. Due to these characteristics, nanogels are referred to as nextgeneration
drug delivery systems and are suggested as promising carriers for dermal applications.
The site-specific delivery of drugs with effective therapeutic effects is crucial in transdermal drug
delivery. The nanogels made from biodegradable polymers can show external stimuliresponsiveness
which results in a change in gel volume, water content, colloidal stability, mechanical
strength, and other physical and chemical properties, thus improving the site-specific
topical drug delivery. This review provides insight into the advances in development, limitations,
and therapeutic significance of nanogels formulations. It also highlights the process of release of
drugs in response to external stimuli, various biodegradable polymers in the formulation of the
nanogels, and dermal applications of nanogels and their role in imaging, anti‐inflammatory therapy,
antifungal and antimicrobial therapy, anti‐psoriatic therapy, and ocular and protein/peptide
drug delivery.
L-Ala-L-Gln Suppresses Hypoxic Phenotype and Fibrogenic Activity of
Rat Perineurial Fibroblasts
Authors: Ghosh Nilabh , Bregere Catherine , Bustos Pia , Guzman Raphael
Published: April 2022

Background:

Twenty million Americans suffer from peripheral nerve injury (PNI) and
approximately $150 billion is spent annually in the United States for the treatment of nerve injuries.
Moreover, 50,000 cases of PNI repairs are performed annually in the United States, with even less
than 42% experiencing satisfactory sensory recovery. Available therapies control painful symptoms
but do not treat axonal degeneration or neuronal cell death. Peripheral nerve fibrosis (PNF) associated
with chronic inflammation, perineural adhesions, and scarring is often reported in patients with
nerve injury. Unfortunately, post-surgical adhesions and fibrosis often lead to aberrated wound healing
and impairment of nerve functions. Various treatment strategies have been attempted, including
the use of grafts and biomaterials; however, few appear promising.

Objective:

L-Alanyl-L-Glutamine (L-Ala-L-Gln) was reported to protect the lung from sepsisinduced
injury and play an immunomodulatory role in stress and fibrosis. This study aimed to examine
the potential anti-fibrotic effects of L-Ala-L-Gln in an in vitro model of neural fibrosis.

Methods:

Primary fibroblasts isolated from rat sciatic nerve were exposed to chronic (48 h) and episodic
(2 h) hypoxic conditions. Cultures were then treated for 48 h with various concentrations of
L-Ala-L-Gln (0, 1, 10, and 100 mM). The expression of hypoxic and pro-fibrotic markers in the different
culture conditions was assessed by immunocytochemistry and western blot analyses. Quantitative
phosphor-proteomic profiling was performed to investigate mechanistically the impact of L-Ala-
L-Gln on collagen biosynthesis and hypoxia-driven tissue fibrosis in vitro.

Results:

In protein expression assays, L-Ala-L-Gln significantly reduced markers related to the cellular
response to hypoxia, in particular HIF-1 signaling. L-Ala-L-Gln also significantly reduced the
expression of pro-fibrotic and cell-adhesion-inducing factors. Phospho-proteomic data indicated that
L-Ala-L-Gln modulates several pro-fibrotic factors and associated pathways.

Conclusion:

Altogether, our data demonstrate that L-Ala-L-Gln efficiently suppresses hypoxiamediated
fibrotic processes at different concentrations in rat primary fibroblasts. Thus, L-Ala-L-Gln
presents a high potential therapeutic value as an antifibrotic pharmaceutical agent for the treatment
of neural fibrosis.
Synthesis, Characterization, and Antibacterial Properties of ZnO
Nanostructures Functionalized Flexible Carbon Fibers
Authors: Aykaç Ahmet , Akkaş Emine Özge
Published: April 2022

Background:

Studies on the surface functionalization of flexible carbon fibers without any
substrate by using cost-effective, fast, and practical processes that may provide antibacterial properties
to carbon fiber have received great importance recently.

Objective:

The objective of this study is to obtain zinc oxide nanostructures functionalized carbon fibers
by a facile, cheap, fast, and repeatable method, and to show their effective antibacterial activity.

Methods:

Electroplating and electrochemical anodization were used to synthesize zinc oxide
nanostructures on carbon fiber surfaces, respectively, and their antibacterial properties were studied by
zone inhibition test against Staphylococcus aureus and Pseudomonas aeruginosa.

Results:

The zinc oxide nanostructures on carbon fiber surfaces were successfully synthesized in
minutes, and they exhibited effective antibacterial properties against Staphylococcus aureus and Pseudomonas
aeruginosa. The morphological properties of the nanocomposite were studied using scanning
electron microscopy, which showed that ZnO on the CF surface exhibits a flake-like nanostructure.
Fourier transform infrared spectrophotometer, x-ray diffraction spectroscopy, Raman spectroscopy, and
x-ray photoelectron spectroscopy were used to analyze the composite's compositional, structural, crystallographic,
and spectral characteristics. The results from all analyses were in a good agreement, indicating
that the wurtzite crystalline ZnO nanostructure was successfully produced on the CF surface.

Conclusions:

As a consequence, a method for the surface functionalization of carbon fiber using zinc
oxide nanostructures has been developed that is feasible, low-cost, rapid, and repeatable. The flexible
nanocomposite structure has a significant potential to be employed as a scaffold in sensor technology,
wearable devices, and particularly in medical textiles due to its antibacterial and woven-able properties.
Growth Hormone Stimulates Murine Macrophage Migration during Aging
Authors: Cruz Borbely Karen Steponavicius , Marques Aldilane Lays Xavier , Porto Felipe Lima , Mendonça Beatriz Santana , Smaniotto Salete , dos Santos Reis Maria Danielma
Published: April 2022

Background:

Age-related impairments in macrophage functions have important consequences
for the health of the elderly population. The aging process is also accompanied by a reduction
in several hormones, including growth hormone (GH). Previous studies have shown that this
hormone can affect macrophage activity in young individuals; however, the biological effects of
GH stimulation on macrophages during aging have not yet been elucidated.

Objective:

The aim of this work was to investigate the in vitro effects of GH on peritoneal macrophages
from aged mice.

Methods:

Peritoneal macrophages isolated from young (4 months-old) and old (12-15 months-old)
mice were treated in vitro with 100 ng/mL of GH for 24 hours. After treatment, cells were analysed
for cell morphology, reactive oxygen species (ROS) production, expression of integrins, cell adhesion
to extracellular matrix molecules, and migration in transwell chambers.

Results:

Although GH-treated cells from old mice exhibited decreased ROS production, we did not
observe the effects of GH on macrophage morphology or macrophage phagocytic activity in young
and old mice-derived cell cultures. Macrophages from old mice had increased adhesion to laminin
and fibronectin substrates, as did cells obtained from young mice treated with GH, but no change
was observed in the expression of integrin receptors. Furthermore, cells from old mice exhibited
increased migration compared to young mice and a significant increase in macrophage migration
was observed under GH stimulation.

Conclusion:

Our results showed that GH can interfere with the motility of macrophages from old
mice, advancing our understanding of the interactions between the immune and neuroendocrine
systems during aging.
Market Integration Analysis of Cayenne Pepper in East Java Province
Authors: Dessy Vetty , Toiba Hery , Fahriyah Fahriyah
Published: April 2022

Market integration research has often been used to evaluate agricultural products' marketing performance. However, the involvement of marketing agencies in chili marketing resulted in a relatively high price difference and impacted market integration. So it is essential to understand how the chili market integration as an effort to improve marketing efficiency and price control policies. The study analyzed the causality and market integration of cayenne pepper prices at the farmers' and retailers' levels in East Java Province. The study used weekly cayenne pepper price data at the farmers' and retailers' levels from 2016 - 2020. The secondary data was obtained from the Department of Industry and Trade of East Java Province. The analytical methods used in this study were Engle-Granger Causality analysis and Error Correction Model (ECM). The findings showed that retail prices caused the farmgate prices, but not the other way. However, the price of cayenne pepper at the farmer and retail level in East Java Province has been integrated. Therefore, this study showed that there needs to be an improvement in the farmers' institutional system to improve the farmers' bargaining position to reduce the power of the selling price control at the farmers' level by traders.
The Effects of Theory-Based Educational Intervention and WhatsApp Follow-up on Papanicolaou Smear Uptake Among Postnatal Women in Malaysia: Randomized Controlled Trial
Authors: Mohammad Zaahirah , Ahmad Norliza , Baharom Anisah
Published: April 2022

Background

Despite the availability and accessibility of free Papanicolaou (Pap) smear as a screening tool for cervical cancer, the uptake of Pap smear in Malaysia has not changed in the last 15 years. Previous studies have shown that the high uptake of Pap smear reduces the mortality rate of patients with cervical cancer. The low uptake of Pap smear is multifactorial, and the problem could be minimized through the use of mobile technologies. Nevertheless, most intervention studies focused on individual factors, while other important aspects such as mobile technologies, especially WhatsApp, have not been investigated yet.

Objective

This study aims to determine the effects of a theory-based educational intervention and WhatsApp follow-up (Pap smear uptake [PSU] intervention) in improving PSU among postnatal women in Seremban, Negeri Sembilan, Malaysia.

Methods

A 2-arm, parallel single-blind cluster randomized controlled trial was conducted among postpartum women from the Seremban district. Twelve health clinics were randomly assigned to the intervention and control groups. At baseline, both groups received a self-administered questionnaire. The intervention group received standard care and PSU intervention delivered by a researcher. This 2-stage intervention module was developed based on Social Cognitive Theory, where the first stage was conducted face-to-face and the second stage included a WhatsApp follow-up. The control group received standard care. Participants were observed immediately and at 4, 8, and 12 weeks after the intervention. The primary endpoint was PSU, whereas the secondary endpoints were knowledge, attitude, and self-efficacy scores for Pap smear screening self-assessed using a Google Forms questionnaire. A generalized mixed model was used to determine the effectiveness of the intervention. All data were analyzed using IBM SPSS (version 25), and P value of .05 was considered statistically significant.

Results

We analyzed 401 women, of whom 76 (response rate: 325/401, 81%) had withdrawn because of the COVID-19 pandemic, with a total of 162 respondents in the intervention group and 163 respondents in the control group. The proportion of Pap smears at the 12-week follow-up was 67.9% (110/162) in the intervention group versus 39.8% (65/163) in the control group (P<.001). Significant differences between the intervention and control groups were found for Pap smear use (F4,1178; P<.001), knowledge scores (F4,1172=14.946; P<.001), attitude scores (F4,1172=24.417; P<.001), and self-efficacy scores (F1,1172=10.432; P<.001).

Conclusions

This study demonstrated that the PSU intervention is effective in increasing the uptake of Pap smear among postnatal women in Seremban district, Malaysia. This intervention module can be tested in other populations of women.

Trial Registration

Thai Clinical Trials Registry TCTR20200205001; https://www.thaiclinicaltrials.org/show/TCTR20200205001
Visible-Light-Driven Photocatalytic Degradation of Rhodamine B over Bimetallic Cu/Ti-MOFs
Authors: Nguyen Hong Tham Thi , Tran Kim Ngan Thi , Tran Thuy Bich , Nguyen Thanh Trung , Do Sy Trung , Nguyen Kim Oanh Thi
Published: April 2022

The first copper-doped titanium-based amine-dicarboxylate metal-organic framework was synthesized by the solvothermal approach in this article, with a Cu2+/Ti4+ ratio of 0.15 (15% Cu/Ti-MOFs). X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectra, N2 adsorption-desorption studies, and UV-Vis diffuse reflectance spectroscopy (UV-Vis DRS) were all used to identify the crystalline and properties of the semiconductors. The rate constants of 15% Cu/Ti-MOFs to degrade Rhodamine B (RhB) were roughly two times higher than NH2-Ti-MOFs. Furthermore, 15% Cu/Ti-MOFs photocatalysts remained stable after three cycles. The trapping test revealed that the principal active species in the degradation performance were hydroxyl radicals and holes.
Intensifikasi Profil Pelajar Pancasila dan Implikasinya Terhadap Ketahanan Pribadi Siswa
Authors: Rusnaini Rusnaini , Raharjo Raharjo , Suryaningsih Anis , Noventari Widya
Published: April 2022

The dynamics of social, national and state life continue to develop along with the development of phenomena, science, and technology. Nowadays, national problems continue to appear in the form of various phenomena that can be said to be actual, but clichéd. In the world of education, recently, for example, several viral news have appeared in the mass media and social media about problems that can be said to be clichés, namely intolerance. News or news about the issue of intolerance, for example, is a recorded conversation between the Principal of SMKN 2 Padang and a student's parents regarding the issue of uniforms for students to wear headscarves even though they are not Muslim. It can be said that this problem is not a new problem, because a few years ago there was also a problem that was essentially the same, only in a different context, namely the prohibition of the use of the hijab in several schools in the province of Bali. Then several other problems also emerged, such as the news about the case of a teacher at SMAN 58 Ciracas, East Jakarta who intervened in the election of the OSIS chairman, as well as what happened at SMAN 6 Depok which had gone viral on social media regarding the same issue, namely the problem of selecting the OSIS chairman. All of these problems are about intolerance. However, there are not a few other problems that occur in the world of primary and secondary education such as problems of radicalism and bullying. These problems are considered as a violation of the values of Pancasila. Therefore, the Ministry of Education and Culture continues to strive to prepare and implement appropriate policies to overcome these various problems. One of the efforts made is by initiating the "Profil Pelajar Pancasila", an ideal profile of Indonesian students, of course according to Pancasila. The purpose of this study is to find out more about the "Profil Pelajar Pancasila", and what its implications are for students' personal resilience. The method used in this study is a qualitative method. The results of the study indicate that the profile referred to in the "Profil Pelajar Pancasila are noble, independent, critical reasoning, creative, mutual cooperation and global diversity. The Ministry of Education and Culture in the idea of a student profile has conveyed what are the indicators of the "Profil Pelajar Pancasila". This profile is an indicator used to measure how the criteria for Indonesian students are in accordance with Pancasila, which was initiated by the Ministry of Education and Culture's Character Strengthening Center. In his study of the "Profil Pelajar Pancasila" which contains characters that refer to Pancasila, it has implications for students' personal resilience, where the Pancasila Student Profile directs students to become individuals with character in accordance with Pancasila which is summarized in a "Profil Pelajar Pancasila".
Pemanfaatan Pesawat Terbang Tanpa Awak untuk Pengamanan Perbatasan Kalimantan dan Dampaknya Terhadap Ketahanan Wilayah
Authors: Anwar Syaiful
Published: April 2022

The Indonesian Government has carried out security in the Indonesia-Malaysia border area by placing various cross-border posts and security posts. The use of Unmanned Aerial Vahicles (UAVs) has proven to be very helpful in reconnaissance, and data collection, even in very difficult terrain conditions. This study aimed to find out more about the benefits of using UAVs in securing land borders in Kalimantan and their impact on the regional resilience.This study was a qualitative research, using a case study approach, which was used because the Researcher wanted to examine in depth the use of the UAV in a limited context and time period. The data used was primary data obtained from relevant informants, and secondary data obtained from official government documents and obtained by the previous researchers. To get the findings, the Researcher analyzed them using the theory of border area management and the theory of national resilience.The findings from the analysis was in the form of the impact of the use of UAVs, that the utilization has been increasing the resilience of border areas by realizing more effective and efficient border management. Thus, within the border area there has been an increase in the protection of various aspects of the regional resilience.
PECES Y MACROCRUSTÁCEOS EN UN ESTUARIO OLIGOSALINO EN EL SO DEL GOLFO DE MÉXICO
Authors: Chávez-López Rafael , Montoya-Mendoza Jesús , Cházaro-Olvera Sergio , Morán-Silva Angel , Vázquez-López Horacio , Rodríguez-Varela Asela del Carmen
Published: April 2022

Se presenta la primera contribución sobre el elenco faunístico acuático de un estuario oligosalino con comunicación esporádica al océano en el golfo de México. Se hicieron muestreos en la laguna El Güiro entre 2015 y 2016, este estuario mantiene un régimen oligosalino de hasta 6 UPS a pesar de que el canal estuarino no se ha abierto desde 2012; se registraron 26 especies de peces y 6 de crustáceos; las familias de peces más numerosas fueron Cichlidae y Gobiidae, las especies dominantes en abundancia y biomasa fueron Poecilia mexicana, Citharichthys macrops y Bathygobius soporator; de los crustáceos la familia más numerosa fue Portunidae y Macrobrachium acanthurus fue la especie dominante; la diversidad de los dos grupos fue baja comparada a la reportada en estuarios comunicados permanentemente al mar. La abundancia y biomasa se relacionó con arribos masivos de las especies dominantes, pero estas no fueron habitantes permanentes en el estuario; la temperatura del agua fue la única variable que se correlacionó positivamente con la abundancia y biomasa totales. Los gremios ecológicos de peces marinos, estuarinos y dulceacuícolas mostraron riqueza de especies similar, todas las especies de crustáceos se han reportado como especies que ocupan los estuarios.
De la esperanza a la militarización: agenda de la política migratoria durante el primer año de la 4T
Authors:   Instituto de Investigaciones Jurídicas, Gandini Luciana , Narváez Gutiérrez Juan Carlos ,   Instituto de Investigaciones Jurídicas
Published: April 2022

De la esperanza a la militarización: agenda de la política migratoria durante el primer año de la Cuarta Transformación (4T) analiza el primer año del actual gobierno de México en materia migratoria. A través de sus páginas se desarrolla un análisis que en doble vía presenta, por un lado, las fases que marcaron el ritmo y el pulso de la política migratoria a lo largo de un año, y por otro lado, una cronología que da cuerpo mes a mes de lo que fue la política y la otra política migratoria. En libro se estructura en dos secciones, en la primera titulada “De la política migratoria en tiempos de la 4T en cuatro momentos” se presentan algunas de las directrices que definieron las formas en que la política migratoria se fue construyendo a lo largo del primer año del actual gobierno de México, y en la segunda parte, titulada “Clave cronológica sobre la política y la otra política migratoria”, se colocan en escena aquello que mes a mes fue cifrando la agenda pública y, por lo tanto, delineando los retos que tiene y tendrá la política migratoria de cara a las dinámicas de las movilidades contemporáneas, que, vale decirlo, cada día son más y más complejas. Este libro es el primer producto del Taller de Monitoreo de Política Migratoria (TMPM), el cual tiene como objetivo realizar un seguimiento cotidiano sobre lo que acontece en línea de tiempo en la agenda pública relacionada con las migraciones y las movilidades internacionales en México y los países vecinos. El TMPM, se basa en un diseño de monitoreo de fuentes de información que sistematiza y analiza la agenda que día a día genera y arroja datos y narrativas sobre los hechos, las acciones, los pronunciamientos, las iniciativas, los comunicados y otras expresiones que forman y dan cuerpo al problema público de la migración o, dicho de otro modo, a la política y a la otra política migratoria del México contemporáneo.
HUBUNGAN MINAT BELAJAR DAN MOTIVASI BELAJAR DENGAN HASIL BELAJAR MATEMATIKA PADA SISWA KELAS V DI MIS NURUL HIKMAH UJUNG PADANG
Authors: Tanjung Yosi Pratiwi
Published: April 2022

The background of the problem based on an initial study conducted by a fifth grade mathematics teacher at MIS Nurul Hikmah Ujung Padang said that the students' mathematics learning outcomes were quite good as seen from the student learning outcomes listed in the students' final reports. From the perspective of learning theory that affects learning outcomes including interest and motivation, in this case there are still students who are lazy in doing homework (PR). Quantitative research is research using a quantitative research design aimed at capturing quantitative data in the form of numerical data using a validated instrument that reflects the dimensions and indicators of the variable and is distributed to a particular population or sample. Based on the method, this study uses the correlational method, which is a study to determine the relationship and level of relationship between two or more variables without any attempt to influence these variables so that there is no variable manipulation. This approach is used to describe the relationship between interest in learning mathematics and motivation to learn mathematics with students' mathematics learning outcomes in class V MIS Nurul Hikmah Ujung Padang. Based on the results of research in this journal, the following conclusions can be drawn: There is a relationship between interest in learning and learning outcomes in mathematics. This can be seen based on data analysis using product moment correlation, obtained a price of 0.436> 0.329. With a significance value of 0.000 <0.05, it means that there is a significant relationship between learning interest and mathematics learning outcomes for fifth grade students at MIS Nurul Hikmah Ujung Padang. There is a relationship between learning motivation and mathematics learning outcomes. This can be seen based on the calculations performed using the product moment, namely (0.486> 0.329). With a significance value of 0.008 < 0.005, it means that there is a significant relationship between learning motivation and mathematics learning outcomes for fifth grade students at MIS Nurul Hikmah Ujung Padang. There is a significant relationship between interest in learning and learning motivation with learning outcomes in mathematics.
Investigating the ambient temperature dependence of EPN/IGS stations positions
Authors: Bovshin N.A.
Published: April 2022

The paper presents the results of studies of individual variations in permanent EPN / IGS stations positions over time, as well as the sources of such variations. In order to eliminate an influence of those perturbation sources, which does not affect station position directly but over surrounding territory, only very small subnets, ranging in size from several meters to several tens of meters, were used for research. It was found, that systematic variations have seasonal nature of behavior (annual variations with extreme values at winter and summer) in most cases and the stations, whose antennas are placed on buildings, have the largest seasonal variations. It was shown, that both the largest individual seasonal variations and the short-time inter-seasonal ones of such stations positions are strongly correlated with local temperature changes. It was shown as well, that varying such stations positions corresponds to expanding-compressing effects of a base where antenna mounted (such as building roof) affected by temperature changes. Some instances of such EPN/IGS station position behavior both from this investigation and other sources were cited. It shows that the main reason of seasonal variations of position of a station, which antenna placed on a building, is the expanding-compressing effect of the building due to changes in ambient temperature.
Um beijo dado mais tarde e a (des)aprendizagem da leitura
Authors: Seeger Gisele
Published: April 2022

A libertação da língua de sua habitual condição de “impostura” é um núcleo semântico disseminado por toda a obra de Maria Gabriela Llansol, mas é n’Um beijo dado mais tarde (1990) que esse núcleo encontra um espaço de “dramatização” ficcional, erigindo-se tanto em construção textual sui generis quanto em experiência dos seres que por esse texto transitam. Persigo aqui o argumento de que a imagem da leitura é nessa obra o nó semântico donde emana a troca duma língua herdada por uma voz adquirida e a principal via por que as figuras reivindicam uma percepção desautomatizada e amplificada dos textos e do(s) mundo(s). Formulações teóricas de Roland Barthes, Hans Robert Jauss e Wolfgang Iser iluminam minha hipótese interpretativa.
Pendampingan Potensi Wisata Kearifan Lokal Batik Motif Khas Satwa Lampung di Desa Labuhan Ratu VII Lampung Timur
Authors: Alimudin Salih , Virna Renata Elsa , L. Rustiati Elly , Sunandar Sunandar , Rahmat Basuki
Published: April 2022

Abstract
Labuhan Ratu VII is one of settlements next to Way Kambas National Park, and has experienced elephants – human conflict. Batik BARATA has developed wildlife motives such as sumatran elephants, tigers and rhinos.  It is potential for ecotourism packages and education as well as wildlife conservation in Lampung.  Its companionship were carried out by off and online from July 2019 - October 2020 under TFCA Sumatra UNILA-ALeRT Consortium program.  BARATA Batik becomes one great ecotourism attractant in Labuhan Ratu VII.
 
Keywords: Companionship, ecotourism, wildlife, Labuhan Ratu VII, TFCA Sumatera
EDUKASI PERILAKU SEKS BEBAS: PERSPEKTIF PSIKOLOGI, KESEHATAN DAN AGAMA DI KECAMATAN TULUNGAGUNG, JAWA TIMUR
Authors: Tarigan Indra Lasmana , Muadifah Afidatul , Arum Wardani Kartika , Elystia Novintan
Published: April 2022

Perilaku seks bebas atau extra-martial intercourse, kinky-seks merupakan bentuk pembebasan seks yang dipandang tidak wajar. Perilaku tersebut memiliki banyak dampak negative diantaranya kehamilan tidak diinginkan, aborsi, risiko terkena infeksi menular seksual (IMS) seperti ulkus mole, klamidia, trikonomiasis, skabies, sifilis, kutil kelamin (kondiloma akunimala), herpes genital, gonorhoeae, dan risiko tertular HIV/AIDS. Di Indonesia, peningkatan jumlah individu yang terpapar HIV/AIDS mengalami peningkatan jumlah orang dengan HIV/AIDS tertinggi di ASEAN sejak 2001 hingga sekarang. Pengabdian masyarakat ini bertujuan untuk memberikan pemahaman tentang perilaku dan kebiasaan sehat masyarakat yang berhubungan dengan sex bebas, untuk memberikan pemahaman komprehensif baik dari perspektif psikologi, kesehatan dan agama. Sehingga masyarakat bisa berpartisipasi sebagai controlling generasi muda agar tidak terjebak dalam perilaku tersebut dan akan berimplikasi pada penurunan kasus HIV/AIDS di Indonesia. Kegiatan ini dilakukan dengan sosialisasi kepada masyarakat dan forum group discussion. Dari hasil evaluasi kegiatan yang dilakukan disimpulkan bahwa kegiatan pelatihan telah memberikan bekal pengetahuan kepada para peserta untuk memahami tentang seks bebas, korelasinya pada kesehatan, dampaknya pada psikologi dan hubungannya dengan agama. Serta telah berjalan secara efektif dengan melihat hasil evaluasi yang sesuai dengan target pencapaian
PENGENALAN ALAT-ALAT OPTIK BAGI GURU-GURU IPA DI SMP NEGERI 1 MUARO JAMBI
Authors: Purwaningsih Sri , Pathoni Haerul , Aina Mia , Pertiwi Rasmi Dian , Murni Pinta
Published: April 2022

Telah dilakukan pengabdian kepada masyarakat  di SMP Negeri 1 Muaro Jambi, pengabdian ini dilakukan terhadap guru-guru IPA. Dari hasil wawancara dengan guru tersebut pembelajaran optik selama ini belum diajarkan melalui praktikum dan percobaan, karena berbagai faktor yang kurang mendukung sehingga praktikum  percobaan fisika sering tidak dilakukan, kendala yang paling banyak  dijumpai adanya keterbatasan alat-alat praktikum yang tersedia. Untuk memahami konsep yang baik, disamping mempelajari teori juga harus disertai dengan praktikum agar dapat memahami konsep dengan baik dan juga menambah minat belajar siswa. Untuk mengatasi masalah tersebut perlu dilakukan pengenalan alat-alat optik dan pada akhirnya melakukan praktikumnya agar guru-guru dapat lebih terampil dan memiliki khasanah yang luas dalam mengajarkan materi optik tersebut. Berdasarkan kegiatan pengabdian kepada masyarakat yang telah dilaksanakan dapat disimpulkan bahwa kegiatan pengabdian sangat dibutuhkan bagi pihak sekolah terutama SMP Negeri 1 Muaro Jambi, dengan adanya kegiatan pengabdian ini,  guru IPA sangat terbantu dengan adanya  pengenalan alat-alat optik dan mendapat menambah inspirasi bagi guru untuk melakukan praktikum  alat-alat optik di sekolah.