bluuebunny/crossref_metadata_2025 huggingface dataset:
Reef fish abundance enhancement through low-cost coral reef restoration practices: a case study in Tioman island, Malaysia
Authors: Baciero Alberto García , Herrero Álvaro García , Anderson Melissa , Berná Eva Horcajo , Gómez Guillermo García , Zamorano Juan Gallego
Published: January 2024

Coral reefs and their inhabitants are threatened by several anthropogenic impacts worldwide. While active coral conservation activities have emerged aiming to maintain reef ecological functions and services, the effect of coral restoration practices on high trophic levels is still poorly investigated. We assessed the effect of small-sized concrete structures on the fish community by comparing the early fish colonization between a treated area and a coral rubble area (used here as control) over 12 months with a monsoon period in between. The treated area nearly doubled in total fish abundance and species richness compared to the control, showing that this method can locally enhance the community of reef fish. Pomacentrus chrysurus was the dominant species in all areas, although Eviota distigma contributed the most to the average between-group dissimilarity between areas (8%, p = 0.02). Fish abundance also exhibited differences between fish life stages (adult, juvenile) (H = 28.852, p < 0.001), among trophic categories (carnivore, omnivore, herbivore, planktivore, and corallivore) (H = 90.615, p < 0.001), and between community types (cryptobenthic and non-cryptobenthic) (H = 52.084, p < 0.001). These effects seem to be boosted by a monsoon period, as the increase of species richness and fish abundance was steeper after the monsoon. Our study shows a positive influence on the reef fish community from the deployment of small-sized concrete structures and highlights human intervention as an essential factor in recovering these iconic ecosystems.
Fueling a Sustainable Future: Surmounting Challenges And Expanding The Frontisers Of Biogas Generation From Pig Slurry.
Authors: JOHNSON NNADIKWE
Published: January 2024

The Transition to a sustainable energy future present numerous challenge that require innovative solutions. This Research delves into the untapped potential of harnessing biogas from pig slurry as a renewable energy source, Highlighting the work conducted by the esteemed Nigerian institute of industrial statisticians (NIIS). As of June 2022, the production of pigs has reached a staggering 3.1 million specimens, creating a substantial opportunity for utilizing their slurry as an organic resource. Through meticulous analysis, it has been determined that pig slurry contains approximately 4,656kg of organic materials generated daily. Drawing from this resource, the daily biogas generation from the fermented pig slurry samples was calculated to be an impressive 1,024m3. Of particular note is the methane formation, which reaches a remarkable 615,615m3 per day, equivalent to an astounding energy output of 22,022Mj/day. The implications of this Research extend beyond mere energy generation. By embracing biogas production from pig slurry., we align ourselves with the United Nations sustainable Development Goals (SDGs). This approach directly contributes to SDGs 7 - Affordable and clean Energy, as well as SDGs12 -Responsible Consumption and production, and SDGs 13-climate Action. By utilizing an abundant waste stream and transforming it into a valuable energy Resource, we address the need for cleaner energy sources while promoting responsible Resource management and reducing greenhouse gas emissions. Expanding the frontiers of biogas generation from pig slurry holds greats promise in our pursuit of a sustainable future. By investing in Research and technology advancements, we can overcome the challenges associated with scaling up this process and maximize it's potential. This innovative approach not only aids in achieving our energy goals but also supports job creation, rural development, and environmental stewardship. Embracing biogas generation from pig slurry is a wise and forward -thinking solutions that addresses the pressing need for sustainable energy sources. By leveraging the findings from NIIS and aligning with the United Nations SDGs, we can create a cleaner and more resilient future, ensuring a balance between economic prosperity and environmental responsibility.
Utilising behavioural and sensory profiles and associated perinatal factors to identify meaningful subgroups in autism spectrum disorder.
Authors: Shirley Jane , John James Rufus , Montgomery Alicia , Whitehouse Andrew , Eapen Valsamma
Published: January 2024

Purpose
The heterogeneity of autism spectrum disorder (ASD) clinically and aetiologically hinders intervention matching and prediction of outcomes. This study investigated if the behavioural, sensory, and perinatal factor profiles of autistic children could be used to identify distinct subgroups.
Methods
Participants on the autism spectrum aged 2 to 17 years and their families were sourced via the Australian Autism Biobank (AAB) resource. Latent class analysis was used to identify subgroups within this cohort, utilising twenty-six latent variables representing child’s behavioural and sensory features and perinatal factors.
Results
4 distinct subgroups within the sample (n = 1168) distinguished by sensory and behavioural autism traits and exposure to perinatal determinants were identified. Class 2 and Class 4, which displayed the greatest behavioural and sensory impairment respectively, were associated with the highest perinatal factor exposure. Class 1, labelled “Most behavioural concerns and moderate sensory and behavioural skills concerns” had mixed exposure to perinatal determinants while Class 3, named “Least sensory and behavioural skills concerns” had the least perinatal determinant exposure, indicating a directly proportional correlation between severity of clinical features and perinatal factor exposure. Additionally, association between specific exposures such as maternal mental illness in Class 1 and significant behavioural concerns was recognised.
Conclusion
Identifying distinct subgroups among autistic children can lead to development of targeted interventions and supports. Close monitoring of children exposed to specific perinatal determinants for developmental differences could assist early intervention and supports.
Water quality's responses to water energy variability of the Yangtze River
Authors: Tian XueQi , Wang Hua , Liang Dongfang , Zeng Yichuan , Shen Yuhan , Yan Yuting , Li Siqiong
Published: January 2024

River energy serves as an indicator of pollutant-carrying capacity (PCC), influencing regional water quality dynamics. In this study, MIKE21 hydrodynamics-water quality models were developed for two scenarios, and grid-by-grid numerical integration of energy was conducted for the Yangtze River's mainstream. Comparison of predicted and measured values at monitoring points revealed a close fit, with average relative errors ranging from 5.17 to 8.37%. The concept of PCC was introduced to assess water flow's ability to transport pollutants during its course, elucidating the relationship between river energy and water quality. A relationship model between Unit Area Energy (UAE) and PCC was fitted (R2 = 0.8184). Temporally, reservoir construction enhanced the smoothness of UAE distribution by 74.47%, attributable to peak shaving and flow regulation. While this flood–drought season energy transfer reduced PCC differences, it concurrently amplified pollutant retention by 40.95%. Spatially, energy distribution fine-tuned PCC values, showcasing binary variation with energy changes and a critical threshold. Peak PCC values for TP, NH3-N, and COD were 2.46, 2.26, and 54.09 t/(km·a), respectively. These insights support local utility regulators and decision-makers in navigating low-carrying capacity, sensitive areas, enhancing targeted water protection measures for increased effectiveness and specificity.
Spatial constraints or spatial dynamics? The spatial spillover effect of networks of flood regulation service flows on land-use degree
Authors: Wang Tao , Li Hongbo
Published: January 2024

In the face of frequent floods under climate and environmental changes, it is particularly important to measure the supply and demand of flood regulation services. Using the Hainan Island as an illustrative case, this study constructs a spatial spillover model to examine the spatial correlation mode and evolution of regional land-use degree through the network of ecosystem service flow. The research results show that forests, grasslands, and reservoirs function as the primary suppliers of flood regulation services, with forests contributing significantly to the regulation of floods. High flood risk was identified in the eastern, northern, and western regions of the Hainan Island, corresponding to increased demand for flood regulation services in croplands, towns, and rural settlements within these areas. The flow of flood regulation services within the Hainan Island was found to be directed from the center to the surrounding areas, with medium and high service flows predominantly concentrated in the northern and surrounding regions. The degree of land use on the Hainan Island demonstrated an influence on socio-economic development. Additionally, the flow network of ecological services was identified as a crucial factor in spatial spillovers, reflecting the level of interaction between county units.
A systematic review on urban blue-green infrastructure in the south Asian region: recent advancements, applications, and challenges
Authors: Gupta Aman , De Bhaskar
Published: January 2024

This study uses a Systematic Literature Review (SLR) process to know the present status of research on urban Blue-Green Infrastructure (BGI) in the lower-middle-income countries of the South Asian region, specifically India, Bangladesh, Sri Lanka, Bhutan, Nepal, and Pakistan, which produced 77 relevant publications after detailed scanning published between 2013 and 2022. It was aimed to analyze variations on BGI's mentions in different regions, identify BGI components found in the literature and their uses to promote urban sustainability, research initiatives, and priorities, and identify knowledge gaps for future research. The review reveals significant differences in research distribution among countries, with the majority of the articles focusing on green spaces compared to bluescapes and concentrating on topics like local inhabitant's perception of urban green spaces, advantages of implementing nature-based solutions, the role of green infrastructures in minimizing the urban heat island effect, air pollution, etc. Articles highlighted the lack of governance and the challenges in implementing and designing a BGI network. However, articles discussing a holistic methodology to implement BGI for promoting urban sustainability were limited. Gaps still exist in determining the appropriate strategy for the scope identification, creation, management, and governance of BGI and integrating it with existing grey infrastructure.
Deciphering Multi-target Pharmacological Mechanism of Cucurbita pepo Seeds
against Kidney Stones: Network Pharmacology and Molecular Docking
Approach
Authors: Shahzadi Aqsa , Ashfaq Usman Ali , Khurshid Mohsin , Nisar Muhammad Atif , Syed Asad , Bahkali Ali H.
Published: January 2024

background:

Urolithiasis is a prevalent condition with significant morbidity and economic implications. The economic burden associated with urolithiasis primarily stems from medical expenses. Previous literature suggests that herbal plants, including Cucurbita pepo, have lithotriptic capabilities. C. pepo is an annual, herbaceous, widely grown, and monoecious vegetative plant known for its antioxidants, fibers, and fatty acids. Recent studies on C. pepo seeds have shown therapeutic potential in reducing bladder stones and urodynamic illnesses like kidney stones. However, the precise molecular and pharmacological mechanisms are unclear.

objective:

In this research, we employed network pharmacology and molecular docking to examine the active compounds and biological mechanisms of Cucurbita pepo against kidney stones.

method:

Active constituents were obtained from previous studies and the IMPPAT database, with their targets predicted using Swiss target pre-diction. Kidney stone-associated genes were collected from DisGeNET and GeneCards. The active constituent–target-pathway network was constructed using Cytoscape, and the target protein-protein interaction network was generated using the STRING database. Gene enrichment analysis of C. pepo core targets was conducted through DAVID. Molecular docking was performed to identify potential kidney stone-fighting agents.

result:

The findings revealed that Cucurbita pepo contains 18 active components and has 192 potential gene targets, including AR, EGFR, ESR1, AKT1, MAPK3, SRC, and MTOR. Network analysis demonstrated that C. pepo seeds may prevent kidney stones by influencing disease-related signaling pathways. Molecular docking indicated that key kidney stone targets (mTOR, EGFR, AR, and ESR1) effectively bind with C. pepo's active constituents.

conclusion:

These findings provide insight into the anti-kidney stone effects of Cucurbita pepo at a molecular level. In conclusion, this study contributes to understanding the potential of Cucurbita pepo in combating kidney stones and lays the foundation for further research.
Molecular Targets and Mechanisms of Hedyotis diffusa Willd. for
Esophageal Adenocarcinoma Treatment Based on Network Pharmacology
and Weighted Gene Co-expression Network Analysis
Authors: Zhuang Yu , Sun Yun-Gang , Wang Chen-Guang , Zhang Qiang , Che Chao , Shao Feng
Published: January 2024

Background::

Hedyotis diffusa Willd. (HDW) is a common anticancer herbal medicine
in China, and its therapeutic effectiveness has been demonstrated in a range of cancer patients.
There is no consensus about the therapeutic targets and molecular mechanisms of HDW, which
contains many active ingredients.

Aim::

To clarify the mechanism of HDW for esophageal adenocarcinoma (EAC), we utilized network
pharmacology and weighted gene co-expression network analysis methods (WGCNA).

Methods::

The gene modules that were linked with the clinical features of EAC were obtained
through the WGCNA method. Then, the potential target genes were retrieved through the network
pharmacology method in order to determine the targets of the active components. After enrichment
analysis, a variety of signaling pathways with significant ratios of target genes were found,
including regulation of trans-synaptic signaling, neuroactive ligand-receptor interaction and modulation
of chemical synaptic transmission. By means of protein-protein interaction (PPI) network
analysis, we have successfully identified the hub genes, which were AR, CNR1, GRIK1, MAPK10,
MAPT, PGR and PIK3R1.

Result::

Our study employed molecular docking simulations to evaluate the binding affinity of the
active components with the hub gene. The identified active anticancer constituents in HDW are
scopoletol, quercetin, ferulic acid, coumarin, and trans-4-methoxycinnamyl alcohol.

Conclusion::

Our findings shed light on the molecular underpinnings of HDW in the treatment of
EAC and hold great promise for the identification of potential HDW compounds and biomarkers
for EAC therapy.
Ferroptosis is Involved in the Pharmacological Effect of Ginsenoside
Authors: Feng Juling , Chen Haodong , Liu Yangbo , Ai Qidi , Yang Yantao , He Wenbin , Zhao Lei , Chu Shifeng , Chen Naihong
Published: January 2024

Ginsenoside is the principal active ingredient in ginseng. Several investigations have
found that ginsenosides have anti-inflammatory, antioxidant, anti-apoptotic, anti-cancer, and antiallergic
activities. Ferroptosis is an iron-dependent, non-apoptotic form of cell-regulated death
caused by lipid peroxidation. Iron, lipid, and amino acid metabolism orchestrate the complex ferroptosis
response through direct or indirect regulation of iron accumulation or lipid peroxidation. More
and more research has demonstrated that ginsenoside impacts illnesses via ferroptosis, implying that
ferroptosis might be employed as a novel target of ginsenoside for disease therapy. This article examines
the molecular mechanism of ferroptosis as well as the current advancement of ginsenoside in
influencing disorders via ferroptosis.
Nanostructured Lipid Carrier-Mediated Transdermal Delivery System of
Glibenclamide for Gestational Diabetes: Pharmacokinetic and
Pharmacodynamic Evaluation
Authors: M. Ashwini , Sudheer Preethi , Sogali Bharani S.
Published: January 2024

Background:

Gestational diabetes mellitus (GDM) poses significant risks during pregnancy
for both mother and fetus. Adherence to oral antidiabetic medications, like glibenclamide (GB),
can be challenging, necessitating novel drug delivery methods. Nanostructured lipid carriers (NLC)
offer a promising approach by efficiently permeating the skin due to their small size and lipid-based
composition.

Objective:

This study aimed to develop and evaluate transdermal patches loaded with glibenclamide
NLCs to treat GDM.

Methods:

Glibenclamide NLCs were prepared using hot homogenization with ultrasonication and
melt dispersion method. A central composite design was utilized to optimize the formulations. Transdermal
patches containing optimized NLCs were developed using HPMC K 100 and Eudragit L polymers.
The patches were evaluated for various parameters, and their pharmacokinetic and pharmacodynamic
studies were carried out to assess their safety and efficacy.

Results:

Optimized NLCs efficiently permeated rat skin. Cell viability studies indicated the nontoxicity
of the formulations. NLC-loaded transdermal patches (F2 and F7) showed drug release of
1098 μg/cm2 and 1001.83 μg/cm2 in 24 h, with a 2.5-fold higher flux and permeation coefficient than
the GB patch. Pharmacokinetic analysis revealed Tmax of 8 and 10 h and Cmax of 7127 ng/ml and 7960
ng/ml for F2 and F7, respectively, ensuring sustained drug action. AUC0-α was 625681 ng/ml·h and
363625 ng/ml·h for F2 and F7, respectively, indicating improved bioavailability.

Conclusion:

Transdermal patches incorporating NLCs hold promise for enhancing glibenclamide's
therapeutic efficacy in GDM treatment. Improved skin permeation, sustained drug release, and enhanced
bioavailability make NLC-based transdermal patches a potential alternative with better patient
compliance.
The Tumor Immune Microenvironment plays a Key Role in Driving the
Progression of Cholangiocarcinoma
Authors: Zhang Ye , Yan Hai-jiao , Wu Jun
Published: January 2024

Cholangiocarcinoma (CCA) is an epithelial cancer distinguished by bile duct cell differentiation
and is also a fibroproliferative tumor. It is characterized by a dense mesenchyme and a
complex tumor immune microenvironment (TME). The TME comprises both cellular and non-cellular
components. The celluar component includes CCA cells, immune cells and mesenchymal
cells represented by the cancer-associated fibroblasts (CAFs), while the non-cellular component is
represented by mesenchymal elements such as the extracellular matrix (ECM). Recent studies
have demonstrated the important role of the TME in the development, progression, and treatment
resistance of CCA. These cell-associated prognostic markers as well as intercellular connections,
may serve as potential therapeutic targets and could inspire new treatment approaches for CCA in
the future. This paper aims to summarize the current understanding of CCA's immune microenvironment,
focusing on immune cells, mesenchymal cells, ECM, intercellular interactions, and
metabolism within the microenvironment.
Cultural determinants of capital structure in Indonesian banking
Authors: Saleh Rinaldy , Isnurhadi  , Malinda Shelfi , Widiyanti Marlina
Published: January 2024

Capital structure decisions play a crucial role in shaping the financial landscape of companies, especially in developing countries. This study examines the cultural determinants of capital structure in Indonesian banking within the macroeconomic context from 2013 to 2022. The capital structure represents the mix of various company funding methods, impacting its value and influencing stakeholders. The debate on how the interplay of debt and assets affects a company's value continues, with the determining factors of capital structure still being explored in financial studies. Using STATA V.17, this research analyzes 30 banking companies listed on the Indonesia Stock Exchange, with leverage as the dependent variable. Financial ratios, including liquidity ratio, profit volatility, growth opportunities, bank size, and external macroeconomic variables such as inflation and Gross Domestic Product (GDP), are examined as potential influencers on the capital structure. The results reveal high leverage in Indonesian banks, with variations in financial approaches. Return on assets, growth opportunities, and inflation exhibit a positive and significant relationship with leverage, while profit volatility, tangibility, bank size, and GDP show a negative and significant relationship. The research suggests limitations in scope, recommending including all Indonesian banking companies and additional external macroeconomic variables like exchange and interest rates.
Integrative motivation and speaking achievement: A study of Indonesian L2 learners of English
Authors: Saragih Tiofani Yasimawarni , Subekti Adaninggar Septi
Published: January 2024

The study investigates English as a second/foreign language (L2) learners’ integrative motivation and its influence on their L2 speaking achievement. It employed a survey method and used speaking test scores to measure L2 speaking achievement. 188 Indonesian L2 learners from non-English departments participated in this study. This study was conducted to fill the gap in the motivation literature which underrecruited L2 learners from non-English departments and lacked quantitative studies involving a sufficient number of such participants in the Indonesian context. Using descriptive statistics on SPSS, the study found that learners generally reported a high level of integrative motivation. Their motivation to make friends with native English speakers was slightly higher than their motivation to learn about native speakers’ cultures and to be involved in native speakers’ communities. Through bivariate linear regression, the study found that learners’ integrative motivation did not influence their L2 speaking achievement. These findings suggested despite integrative motivation being established in L2 literature, it did not always translate into motivated behaviours. This also calls for a re-examination of some pedagogical practices orienting towards native speakers and their cultures.
Caracterización del secado del maíz duro amarillo en el Cantón Quevedo
Authors: Mancheno Edison , Moreira Mercedes , Jácome Walter , Padilla Kevin , Remache Michael
Published: January 2024

Corn drying reduces the moisture content to levels that guarantee the conservation of the quality characteristics demanded by the food industry. The different piladoras located in the canton of Quevedo, in the Province of Los Ríos, use stationary systems for corn drying due to the advantages in terms of operation and functioning. This research aims to analyze the influence of the moisture content of corn on the drying process. For this study, the corn production corresponding to the second harvest period was considered. The results allowed determine that with an average corn moisture content of 31.55%, an estimated drying time of 4 hours and 15 minutes to reach levels of 13% wet basis; however, after this time, the moisture concentration of the grain remains above this value, which implies that the production lot must remain exposed to high temperatures for a more extended period, which affects the final quality of the grain and the efficiency of the process. Environmental conditions also influence the process since corn is produced and harvested in two periods per year, which means that production takes place when the grain has reached physiological maturity.

Keywords: Quality; Impurities; Moisture content; Drying Process
Mapping the Cardiometabolic Patient Experience and Self-Care Behaviors to Inform Design, Implementation, and Persistent Use of Digital Health Care Solutions: Mixed Methods Study
Authors: Liska Jan , Mical Marie , Maillard Christophe , Dessapt Cécile , Bendig Europa , Mai Daniel , Piette John D , De Geest Sabina , Fontaine Guillaume
Published: January 2024

Background

Cardiometabolic conditions including acute coronary syndrome (ACS) and type 2 diabetes (T2D) require comprehensive care and patient engagement in self-care behaviors, and the drivers of those behaviors at the individual and health system level are still poorly understood.

Objective

We aim to gain insights into self-care behaviors of individuals with cardiometabolic conditions.

Methods

A convenience sample of 98 adult patients with ACS and T2D was recruited in the United States, Germany, and Taiwan to participate in a mixed methods study using ethnographic methods. All participants completed 7-day web-based diaries tracking their level of engagement, and 48 completed 90-minute web-based semistructured interviews between February 4, 2021, and March 27, 2021, focusing on themes including moments of engagement. Qualitative analysis identified factors influencing self-care practices and a Patient Mind States Model prototype.

Results

Patient reports indicate that many patients feel social pressure to adhere to treatment. Patients’ experience can be understood within 5 categories defined in terms of their degree of engagement and adherence (“ignoring,” “struggling,” “juggling,” “controlling,” and “reframing”).

Conclusions

For people living with ACS and T2D, the self-care journey is defined by patterns of patient experiences, which can identify areas that tailored digital health care interventions may play a meaningful role.
Role of Ethics in Developing AI-Based Applications in Medicine: Insights From Expert Interviews and Discussion of Implications
Authors: Weidener Lukas , Fischer Michael
Published: January 2024

Background

The integration of artificial intelligence (AI)–based applications in the medical field has increased significantly, offering potential improvements in patient care and diagnostics. However, alongside these advancements, there is growing concern about ethical considerations, such as bias, informed consent, and trust in the development of these technologies.

Objective

This study aims to assess the role of ethics in the development of AI-based applications in medicine. Furthermore, this study focuses on the potential consequences of neglecting ethical considerations in AI development, particularly their impact on patients and physicians.

Methods

Qualitative content analysis was used to analyze the responses from expert interviews. Experts were selected based on their involvement in the research or practical development of AI-based applications in medicine for at least 5 years, leading to the inclusion of 7 experts in the study.

Results

The analysis revealed 3 main categories and 7 subcategories reflecting a wide range of views on the role of ethics in AI development. This variance underscores the subjectivity and complexity of integrating ethics into the development of AI in medicine. Although some experts view ethics as fundamental, others prioritize performance and efficiency, with some perceiving ethics as potential obstacles to technological progress. This dichotomy of perspectives clearly emphasizes the subjectivity and complexity surrounding the role of ethics in AI development, reflecting the inherent multifaceted nature of this issue.

Conclusions

Despite the methodological limitations impacting the generalizability of the results, this study underscores the critical importance of consistent and integrated ethical considerations in AI development for medical applications. It advocates further research into effective strategies for ethical AI development, emphasizing the need for transparent and responsible practices, consideration of diverse data sources, physician training, and the establishment of comprehensive ethical and legal frameworks.
An Assessment of the University Usage of Social Media Platforms: Case from Lebanon—Analytics—Part 2
Authors: Bashir Eman , Hejase Hussin J. , Danach Kassem , Yassin Wissam , Hejase Ale J.
Published: January 2024

This paper, the second part of two, aims to provide results and findings to support the main objective of the research, i.e., to assess how a selection of Lebanese Universities utilizes social media platforms to attract potential student candidates. Social Media in the last decade has become a significant recruitment media adopted by universities around the globe, including Lebanon, to attract and effectively recruit millennial high school graduates who are digitally proficient and smart. Six universities were involved, so capturing recorded activity is essential to assess such efforts and pinpoint gaps that must be addressed to justify student recruitment investments by universities. This study is based on a mixed approach though with a concentration on the quantitative, deductive, and descriptive approaches capitalizing on collected data from the different university social media platforms and performing the required analysis to help categorize selected universities in their efforts, successes, and gaps. This paper shows the numerical, graphical, and discussion analyses of the results. Results confirm there is a lack of motivation schemes to attract potential candidates and encourage them to interact with such platforms. Moreover, universities lack specialized digital marketing staff to produce the appropriate content and design marketing strategies that are attractive, interactive, and with high response rates to inquiries.
Usability of fractometer for the purpose of a practical preliminary assessment tool for wood density of Pinus brutia
Authors: Icel Bilgin
Published: January 2024

The fractometer is a device that breaks increment cores to measure fracture strength. The advantages of the device are that it is relatively fast, easy to use in the field, and it can perform direct strength measurements on increment cores. The main purpose of the study was to evaluate the usability of the fractometer as a preliminary evaluation tool for wood density traits of standing Turkish Pinus brutia (red pine) trees. Fracture strength was measured on 5 mm diameter increment cores, and X-ray densitometry was used for density measurements. Due to the high correlation between the two traits (fracture and density), a model was built using linear regression. Fifty trees were sampled to build the statistical model (r2: 0,74), and an equal sample size was used to test the model. The density value obtained from the model was 0,546 gcm-3, while the density value averaged by the X-ray method for the same group was 0,543 gcm-3. When considering mean values, it can be said that the model provides a good prediction. Based on personal experience and research results, some trees exhibited better growth and wood quality traits than others. Breeding from these trees could offer improvement in timber production and performance for Pinus brutia (red pine). As a general consequence, the fractometer and increment core sampling can be used for pine tree breeding programs for the preliminary assessment of wood density.
More than just a tree: Ecolinguistics and responses to the felling of ‘Hadrian’s tree’
Authors: Ponton Douglas Mark
Published: January 2024

In the current climate ecolinguistic research has arguably never been more important, as its basic premises regard the survival of life on Earth and key philosophical questions hitherto under-acknowledged by mainstream science. In recent decades, environmental thinking has made great advances in shaping current opinions towards nature and the non-human world. The goal of this paper is to explore certain currents of mediated thinking in modern Britain regarding nature, in order to assess how far expressions of sorrow for the felling of a prominent tree might correspond to a genuine ecological sentiment. The study explores public responses to an apparent case of eco-vandalism, the felling of the Sycamore Gap tree in September 2023 in Northumberland, using data taken from social media and other online sources such as e-newspapers. From the point of view of Ecolinguistic theory and that of Positive Discourse Analysis it applies critical lenses such as Evaluation and Discourse Pragmatics to dig beneath the surface of texts produced on the topic, in order to explore diverse current attitudes to trees in the UK. The paper finds that, though there are instances in which people appear to express grief for the loss of the Sycamore Gap tree, it is possible to account for these in ways that lessen the likelihood that they are motivated by purely ecological sentiment. In practice human attitudes towards trees tend to be superficial and instrumental, and this tendency is also found here. The Sycamore Gap event brings many latent social attitudes into play, and this paper thus contributes to the developing field of Ecolinguistics by focusing on tree-centred narratives, distinguishing between inherent ideologies of pseudo- and authentic environmental sensitivity.
Nicole Baumgarten and Roel Vismans (eds.). 2023. It’s different with you: Contrastive perspectives on address research. [TAR 5]. John Benjamins Publishing Company
Authors: Bilá Magdaléna
Published: January 2024

-
KONSEP MODAL KEROHANIAN MENURUT PERSPEKTIF EKONOMI ISLAM The Concept of Spiritual Capital from Islamic Economic Perspective
Authors: Wahid Hairunnizam , Nik Ab Malik Nik Mohd Azim , Ismail Mohd Adib
Published: January 2024

Spiritual capital is essential for promoting the quality of economic growth. Spiritual capital is a multidimensional and flexible concept. Consequently, the concept has been discussed in numerous social science and humanities disciplines, such as theology, economics, sociology, etc. The discussion has produced numerous definitions of the concept of spiritual capital. Therefore, the purpose of this study is to examine the concept of spiritual capital from an Islamic economics perspective. Qualitative methode has been used in this research where relevant literatures have been critically reviewed. Spiritual capital, according to Islamic economics, is an intangible asset in the form of a source of inner strength that is fueled by the accumulation of religious knowledge and spiritual practices based on both obligatory and supererogatory worships in Islam, which can have a positive impact on those who invest in it.
Living Lab Mais Juntas: a universidade extensionista como orquestradora da cocriação de inovação social
Authors: Bolzan Larissa , Mattos Fernandes Daniela
Published: January 2024

O objetivo deste artigo foi compreender o papel de ações extensionistas de uma universidade pública no processo de cocriação de inovações sociais. Para tanto, o Living Lab Mais Juntas serviu como objeto de análise. O método para desenvolvimento deste trabalho foi a pesquisação. De modo geral, esta pesquisa evidenciou que em ações de extensão a universidade é capaz de orquestrar o processo de cocriação de inovações sociais, uma vez que no Living Lab Mais Juntas, todas ações foram planejadas e organizadas pelo Projeto unificado com ênfase em extensão Mais Juntas da UFPel. É valido destacar ainda que a utilização do método de cocriação Design Sprint possibilitou a mobilidade de conhecimento manutenção da estabilidade da rede e comunicação horizontal e a construção do capital relacional entre os atores.
Płynność i rentowność w zmodyfikowanym modelu Du Ponta. Próba weryfikacji
Authors: Franc-Dąbrowska Justyna , Bereżnicka Joanna
Published: January 2024

W artykule podjęto próbę zweryfikowania przydatności modelu Du Ponta w jego zmodyfikowanej wersji do obliczenia wskaźników płynności. Próbę badawczą stanowiły spółki akcyjne sektora rolno-spożywczego w latach 2001-2006. Stwierdzono, że zmodyfikowany model Du Ponta nie pozwala na uzyskanie wskaźników płynności identycznych z tymi, które można obliczyć w tradycyjny sposób. Uznano, że nie dyskwalifikuje to jednak zmodyfikowanej wersji modelu Du Ponta, wymaga jednak ostrożności w formułowaniu wniosków i weryfikacji innymi metodami.
Gospodarstwa towarowe a gospodarstwa wielkotowarowe
Authors: Józwiak Wojciech , Kagan Adam
Published: January 2024

W opracowaniu przeanalizowano sytuację finansową różnych pod względem wielkości ekonomicznej i formy prawnej grup gospodarstw towarowych i wielkotowarowych. Na podstawie tej analizy i wielkości prowadzonych inwestycji dokonano oceny, która z grup gospodarstw ma podstawy do trwałej egzystencji, a która jest schyłkowa. Stwierdzono współzależność pomiędzy rozmiarami działalności rolniczej, a realizowaną opłatą pracy własnej i poziomem zwrotu z zainwestowanego kapitału. Wskazano na potencjalne skutki zmiany polityki rolnej dla wyodrębnionych zbiorowości.
Gospodarstwa wielkoobszarowe w różnych scenariuszach uwarunkowań ekonomicznych w perspektywie roku 2013. Studium przypadku
Authors: Sulewski Piotr , Wąs Adam
Published: January 2024

W opracowaniu przedstawiono wyniki ekonomiczne oraz niezbędne dostosowania w strukturze produkcji czterech gospodarstw wielkoobszarowych w perspektywie roku 2013. Analizę przeprowadzono dla trzech potencjalnych scenariuszy sytuacji ekonomicznej. Podstawą porównań był rok bazowy 2006. Do obliczeń wykorzystano liniowy model optymalizacyjny gospodarstwa rolnego.
Intensywność produkcji a efektywność ekonomiczna wielkoobszarowych przedsiębiorstw rolniczych
Authors: Kasztelan Paweł
Published: January 2024

Omówiono zmiany intensywności produkcji w wielkoobszarowych przedsiębiorstwach rolniczych w latach 1998-2005. Badania przeprowadzono na grupie przedsiębiorstw, które nieprzerwanie w tym okresie brały udział w Rankingu 300 najlepszych przedsiębiorstw rolniczych. W wyniku przeprowadzonej analizy stwierdzono, że przedsiębiorstwa rolnicze systematycznie zwiększały intensywność produkcji pomimo niekorzystnych relacji w zakresie zmian cen produktów i środków do produkcji. Wzrostowi intensywności towarzyszył wzrost produktywności, co w konsekwencji pozwoliło na uzyskanie lepszych wyników w zakresie rentowności prowadzonej działalności.
Wykorzystanie bilansu majątkowego w ocenie stanu i kierunków zmian sytuacji ekonomiczno-finansowej przedsiębiorstw hodowlanych
Authors: Runowski Henryk
Published: January 2024

Przedstawiono możliwości wykorzystania bilansu do oceny sytuacji majątkowej i ekonomiczno-finansowej przedsiębiorstw hodowli roślin i zwierząt Agencji Nieruchomości Rolnych. Zbadano kształtowanie się poziomu, dynamiki oraz struktury aktywów i pasywów badanych przedsiębiorstw w latach 1997-2007. Uzyskane wyniki mogą stanowić podstawę do porównywania wyników przez poszczególne przedsiębiorstwa hodowli roślin i zwierząt do zaprezentowanych w artykule średnich wartości dla całej grupy tych przedsiębiorstw.
Optymalizacja struktury sprzedaży w spółdzielni mleczarskiej
Authors: Mądra Magdalena , Chmielewska Marzena
Published: January 2024

Celem bada? było określenie optymalnej struktury kwartalnej wielkości sprzedaży w wybranej spółdzielni mleczarskiej. Obiekt do badania został wybrany jako typowy, z czterdziestu celowo dobranych spółdzielni mleczarskich. We wszystkich trzech przyjętych wariantach rozliczania kosztów pośrednich na wyroby, optymalna struktura sprzedaży pozostawała bez zmian. Przyczyną takiej sytuacji mógł być fakt, iż w produkcji mleczarskiej koszty pośrednie stanowią niewielki odsetek ogółu kosztów całkowitych, co wpływa marginalnie na zyskowność w skali pojedynczego produktu, a tym samym na strukturę sprzedaży
Przegląd tematyczny oraz ocena bibliometryczna dorobku naukowego zaprezentowanego na XII kongresie Europejskiego Stowarzyszenia Ekonomistów Rolnych w Gandawie
Authors: Zawojska Aldona
Published: January 2024

W artykule dokonano analizy tematycznej i bibliometrycznej, której obiektem są 392 prace opublikowane w materiałach z XII Kongresu Europejskiego Stowarzyszenia Ekonomistów Rolnych w Gandawie. Przy zastosowaniu metod bibliometrycznych określono geograficzny rozkład artykułów i autorów, dokonano analizy produktywności autorów wykorzystując prawo Lotki, zbadano skalę współautorstwa i współpracy międzynarodowej, przeprowadzono analizę cytowań w artykułach źródłowych oraz wyodrębniono, przy użyciu języka haseł przedmiotowych, główne obszary badawcze.
Turystyka w województwie warmińsko-mazurskim. Stan obecny i perspektywy rozwoju
Authors: Karbowiak Katarzyna
Published: January 2024

W opracowaniu zaprezentowano stan obecny turystyki na obszarze województwa warmińsko-mazurskiego oraz perspektywy rozwoju tej formy aktywności. Wykorzystano dane pochodzące z Urzędu Statystycznego, Regionalnego Programu Operacyjnego na lata 2007-2013. Warmia i Mazury dysponują znaczącymi w skali europejskiej walorami przyrodniczymi, krajobrazowymi oraz kulturowo-etnicznym, które określają przewagę konkurencyjną i świadczą o wysokiej atrakcyjności turystycznej regionu. Na podstawie przeprowadzonej analizy SWOT stwierdzono, iż potencjał ten nie jest wystarczająco dobrze wykorzystany, przede wszystkim ze względu na zły stan infrastruktury turystycznej. Działania dotyczące eksponowania silnych stron, ukrywania słabości, wykorzystywania szans i eliminowania zagrożeń mogą doprowadzić w przyszłości do wzrostu znaczenia turystyki w gospodarce regionu.
A rare case of alpha-methyldopa-induced hepatitis in pregnancy
Authors: Likic-Ladjevic Ivana , Petronijevic Milos , Vrzic-Petronijevic Svetlana , Beleslin Aleksandra , Dugalic Stefan
Published: January 2024

Introduction. There are three groups of disorders during pregnancy: disorders specific for pregnancy that resolve spontaneously or soon after delivery, acute hepatic disorders coinciding with pregnancy, and chronic disorders. Drug-induced liver disease prevails among women and it is estimated to be a leading cause of acute liver injury. Drug-induced hepatitis is rare in pregnancy with only a few cases reported in literature. Alpha-methyldopa is one of the commonly used drugs in pregnancy that could cause hepatotoxicity with different clinical presentations and possible adverse effects on normal course of pregnancy. Case outline. We reported a rare case of hepatotoxicity caused by alpha-methyldopa in 26 gestational weeks pregnancy in a 35-year-old patient admitted because of jaundice and elevated liver function tests. She had been using antihypertensive drug, alpha-methyldopa, from 12th gestational week, and no other medication or supplementation was recorded. Ultrasound of the abdomen excluded obstruction or any other abnormalities. Autoimmune panel was done. Biochemical analyses were indicative of toxic acute liver injury caused by alpha-methyldopa according to values of transaminase. After 13 days, patient was discharged recovered from the hospital. Conclusion. Diagnosis of alpha-methyldopa hepatotoxicity is challenging since the low incidence, unpredictability, diverse symptomatology and absence of specific biomarkers. That is why timely diagnosis is crucial for the well-being of both future mother and child.
KD025 Is a Casein Kinase 2 Inhibitor That Protects Against Glucolipotoxicity in β-Cells
Authors: Devkota Ranjan , Small Jonnell C. , Carbone Kaycee , Glass Michael A. , Vetere Amedeo , Wagner Bridget K.
Published: January 2024

Glucolipotoxicity (GLT), in which elevated levels of glucose and fatty acids have deleterious effects on β-cell biology, is thought to be one of the major contributors in progression of type 2 diabetes. In search of novel small molecules that protect β-cells against GLT, we previously discovered KD025, an inhibitor of Rho-associated coiled-coil–containing kinase isoform 2 (ROCK2), as a GLT-protective compound in INS-1E cells and dissociated human islets. To further understand the mechanism of action of KD025, we found that pharmacological and genetic inhibition of ROCK2 was not responsible for the protective effects of KD025 against GLT. Instead, kinase profiling revealed that KD025 potently inhibits catalytic subunits of casein kinase 2 (CK2), a constitutively active serine/threonine kinase. We experimentally verified that the inhibition of one of the catalytic subunits of casein kinase 2, CK2A1, but not CK2A2, improved cell viability when challenged with GLT. We conclude that KD025 inhibits CK2 to protect β-cells from GLT.

Article Highlights
Best Practice Perspectives on Improving Early Detection and Management of Chronic Kidney Disease Associated With Type 2 Diabetes in Primary Care
Authors: D. Goldman Jennifer , Busch Robert , Miller Eden
Published: January 2024

Chronic kidney disease (CKD) is a progressive disease that can lead to kidney failure and increases the risk of cardiovascular disease (CVD), cardiovascular mortality, and all-cause mortality (1,2). Diabetes is a major risk factor for developing CKD (3) and CVD independent of CKD (4). Approximately 37 million people in the United States have CKD, and most (90%) are unaware they have the condition, so their CKD remains undiagnosed in primary care (3). Although treatment guidelines recommend screening at least annually for CKD in people with type 2 diabetes (5–7), uptake of screening for CKD in adults with diabetes remains low in routine clinical care (8). In the United States, prescription rates of guideline-recommended medications that have been shown to prevent CKD progression in people with CKD associated with type 2 diabetes also remain low (9,10).
Prevalence, Surgical, and Medical Management of Patients with Endometriosis amongst Indian Women
Authors: Rozati Roya , Tabasum Wajeeda , Ahmed Mohammed Sarosh , Khan Aleem Ahmed , Ahmed Talia Nazeer , Nayela Sumaiya , Azimi Salwa Sahar
Published: January 2024

Objective: This study aims to determine the prevalence of endometriosis in women in South India, the epidemiological factors involved, and evaluate the symptomatic burden associated with it.
Design: A large-scale Hospital-based study was conducted among women of reproductive age (16 to 44 years) in the state of Telangana between March 2018 and March 2023. A randomized multi-stage stratified sampling method was adopted and included 2,400 women who were screened using a validated structured questionnaire. Patients presenting with symptoms indicative of endometriosis underwent additional assessment using abdominal ultrasonography (AUS) and serum cancer antigen 125 (CA125) tests. For confirmation, laparoscopy was offered to the patients who consented. Patients who declined laparoscopy were given the option of undergoing magnetic resonance imaging (MRI) instead.
Results: Among 2,400 women who participated, 60 women have been diagnosed with endometriosis during the 5-year study period. The prevalence of endometriosis was found to be 2.5%. The mean age of participants was 15.2 ± 3.5 years and the mean age at menarche was found to be 12.9 ± 1.1 years. Out of 60 participants diagnosed with endometriosis 30% (n = 18) experienced irregular menstrual cycles. Approximately 33.3% (n = 20) of the women reported experiencing Dysmenorrhea, with 28.4% (n = 17) complaining of dyspareunia. Among the cases with menstrual pain, exhibited ultrasound findings suggestive of endometriosis, with elevated CA125 levels observed in 45% (n = 27) of these cases. All 60 patients who consented to laparoscopic confirmation, exhibited positive histo-pathological evidence of endometriosis. The prevalence of endometriosis is found to be significant in women of reproductive age group and found to be associated with high rates of infertility in 15 (25%) patients. The results of this study showed that the prevalence of endometriosis is found to be 2.5% which is similar to the other studies reported. The severity of endometriosis during laparoscopy was assessed using the rAFS staging system, revealing rates of 55% and 45% for disease in Stages I & II, Stages III, & IV, respectively.
Conclusion: Our study concludes that endometriosis predominantly affects women in the reproductive age group and is often associated with primary infertility. The laparoscopic findings are identified as a standard tool for both diagnosis and treatment of endometriosis.