bluuebunny/crossref_metadata_2025 huggingface dataset:
A new fusion neural network model and credit card fraud identification
Authors: Jiang Shan , Liao Xiaofeng , Feng Yuming , Gao Zilin , Onasanya Babatunde Oluwaseun
Published: October 2024

Credit card fraud identification is an important issue in risk prevention and control for banks and financial institutions. In order to establish an efficient credit card fraud identification model, this article studied the relevant factors that affect fraud identification. A credit card fraud identification model based on neural networks was constructed, and in-depth discussions and research were conducted. First, the layers of neural networks were deepened to improve the prediction accuracy of the model; second, this paper increase the hidden layer width of the neural network to improve the prediction accuracy of the model. This article proposes a new fusion neural network model by combining deep neural networks and wide neural networks, and applies the model to credit card fraud identification. The characteristic of this model is that the accuracy of prediction and F1 score are relatively high. Finally, use the random gradient descent method to train the model. On the test set, the proposed method has an accuracy of 96.44% and an F1 value of 96.17%, demonstrating good fraud recognition performance. After comparison, the method proposed in this paper is superior to machine learning models, ensemble learning models, and deep learning models.
Identifying the zero-dose and under-immunized children in Bangladesh: Approaches and experiences
Authors: Jannat Zerin , Das Hemel , Ali Md. Wazed , Alam Nurul , Chowdhury Mahbub E. Elahi Khan , Sarker Bidhan Krishna , Rahman Md. Mahbubur , Mahmood Shehrin Shaila , Rahman Md. Musfikur , Morgan Christopher , Oliveras Elizabeth , Correa Gustavo Caetano , Reynolds Heidi W. , Wahed Tasnuva , Uddin Md. Jasim
Published: October 2024

This paper presents and elaborates on empirical methods and approaches used to identify Zero-Dose (ZD) and Under-immunized (UI) children as well as the communities that these children reside in within Bangladesh. This paper also describes demand- and supply side-barriers that lead to children being ZD and UI in the country. Time period for the study was December 2022—May 2023. The study methodology encompassed secondary data analysis using data from national surveys, primary data collection and analysis via a lot quality assurance sampling (LQAS) survey and also, qualitative data collection and analysis. Study population included caregivers of children aged 4.5 months (4 months 15 days) to 23 months for the LQAS survey. The qualitative component included policymakers, program managers and service providers working in immunization as well as mothers in the selected study areas who had a living child aged less than 2 years as the study population. Our data analysis confirms existence of ZD and UI children in areas which were categorized into haor (wetlands), hilly, char (sandy/silty land surrounded by water), coastal, plain land and urban slums. Determinant analysis showed that the mother’s level of education, antenatal visits made, and access to media were significantly associated with children being ZD or UI. Reproductive autonomy emerged as a key factor that had prominent impact on a child being ZD. The qualitative analysis indicated the importance of population migration, health workforce shortages and lack of access to transportation as prominent barriers to immunization. Notably, the methods and approaches used in this study are both effective and easily replicable to identify ZD and UI children. The drivers of ZD and UI along with the barriers to immunization provide potential areas for intervention by policy-makers and can apprise about interventions to be tested in future implementation research.
Measurement invariance of the Center for Epidemiological Studies-Depression scale and associations with genetic risk in older adults
Authors: Saari Toni T. , Piirtola Maarit , Aaltonen Aino , Palviainen Teemu , Varjonen Anni , Julkunen Valtteri , Rinne Juha O. , Kaprio Jaakko , Vuoksimaa Eero
Published: October 2024

Background

As populations are aging, it needs to be ensured that valid depression rating scales are available across old adulthood. Center for Epidemiological Studies-Depression scale (CES-D) is a common depression rating scale, however, few studies have assessed its validity in individuals with age over 90 and/or cognitive impairment. We examined the factor structures of 20-, 15-, and 8-item CES-D scales, their measurement invariance for age and cognition, and associations with genetic risk of depression.

Methods

Participants were from a population-based older Finnish Twin Cohort study including 71–79-year-olds from the MEMTWIN II (n = 1034 for exploratory and n = 664 for confirmatory factor analyses) and 90+ year-olds from the NONAGINTA (n = 134, confirmatory factor analyses) sub-studies. Associations of polygenic risk score of major depressive disorder (MDD-PRS) with CES-D scales were examined in MEMTWIN II.

Results

Exploratory factor analyses (n = 1034) suggested four- (CES-D 20) and three-factor (CES-D 8) structures and these models fit well in confirmatory analyses (n = 664). Unidimensional models had good (CES-D 15 & 20) or fair fit (CES-D 8). Results supported scalar invariance of all CES-D versions for age and cognitive status. Higher MDD-PRS was associated with more depressive symptoms in different CES-D versions.

Conclusions

Different CES-D versions are adequate for measuring depressive symptoms across age groups and cognitive spectrum in old age. Genetic risk of depression predicts depressive symptoms even in old age.
Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development
Authors: Reimels Theresa A. , Steinberg Mia , Yan Hua , Shahar Sivan , Rosenberg Ashley , Kalafsky Kristina , Luf Max , Kelly Lindsay , Octaviani Stacia , Pfleger Cathie M.
Published: October 2024

Rabex-5 (also called RabGEF1), a protein originally characterized for its Rab5 GEF function, also has an A20-like E3 ubiquitin ligase domain. We and others reported that Rabex-5 E3 activity promotes Ras mono- and di-ubiquitination to inhibit Ras signaling in Drosophila and mammals. Subsequently, we reported that Rabex-5 inhibits Notch signaling in the Drosophila hematopoietic system. Here we report genetic interactions using Rabex-5 transgenes encoding domain-specific mutations that show that Rabex-5 requires an intact E3 domain to inhibit Notch signaling in the epithelial tissue of the developing wing. Surprisingly, we discovered that Rabex-5 with an impaired E3 domain but active Rab5 GEF domain suppresses Notch loss-of-function phenotypes and enhances both Notch duplication phenotypes and activated Ras phenotypes consistent with a model that the Rab5 GEF activity of Rabex-5 might positively regulate Ras and Notch. Positive and negative regulation of developmental signaling by its different catalytic domains could allow Rabex-5 to precisely coordinate developmental signaling to fine-tune patterning. Finally, we report that Rabex-5 also inhibits the overgrowth due to loss of PTEN or activation of PI3K but not activation of AKT. Inhibition of Ras, Notch, and PI3K signaling may explain why Rabex-5 is deleted in some cancers. Paradoxically, Rabex-5 is reported to be an oncogene in other cancers. We propose that Rabex-5 acts as a tumor suppressor via its E3 activity to inhibit Ras, Notch, and PI3K signaling and as an oncogene via its Rab5 GEF activity to enhance Ras and Notch signaling.
Exploring the impact on contact adhesion layer properties in numerical simulations
Authors: Shamim Reza
Published: October 2024

This paper presents a comprehensive investigation into the impact of key parameters on contact adhesion layer properties using numerical simulations, addressing fundamental questions in contact mechanics. Aiming to explore interfacial penetration and contact pressure dynamics between a wavy punch and an adhesive-coated body, the study focuses on the influence of adhesive layer thickness, elasticity modulus, and punch geometry on mechanical behavior. The study includes the application of Green’s function to address deficiencies in existing models, revealing how contact stiffness, influenced by the flexibility relationship between the coating and substrate, affects the size of the contact area. Finally, conclusions are drawn that adjusting coating factors can induce full contact conditions. Quantitative analysis shows a 2.23-fold increase in load-bearing capacity with a 2 mm increase in adhesive layer thickness, and a 23-fold increase with a toughness ratio rise from 0.1 to 5. These findings are recommended for optimizing adhesive layer properties, contributing to advancements in materials science and innovation.
Clinical significance of MRI-measured olfactory bulb height as an imaging biomarker of idiopathic Parkinson’s disease
Authors: Park Sohyun , Lee Jungbin , Kim Jung Youn , Park Jeong-Ho , Lee Ji Eun , Park Sang Ik , Yim Younghee
Published: October 2024

Objectives

This study aimed to determine whether the olfactory bulb height (OBH) measured using magnetic resonance imaging (MRI) has clinical utility as an imaging biomarker in the evaluation of patients with idiopathic Parkinson’s disease (iPD) through its correlation with movement impairment.

Methods

This retrospective study included cognitively intact patients with suspected parkinsonism. All participants underwent T2-weighted imaging to measure OBH. Logistic regression was used to determine whether OBH was an independent risk factor for distinguishing iPD patients from disease controls, and its relation with clinical parameters related to motor impairment, including clinical laterality, modified Hoehn and Yahr (HY) stage, and Unified Parkinson’s Disease Rating Scale (UPDRS) III score, was investigated.

Results

Based on the final clinical diagnosis, 79 patients with iPD and 16 disease controls were included. The mean OBH was significantly smaller in iPD than in disease controls (p < 0.0001). OBH was a significant independent predictor of iPD, with a cutoff of 1.52 mm. In the comparison among the ipsilateral, contralateral side of iPD with clinical laterality, and disease control group, the OBH of the disease control group was significantly larger than both the ipsilateral and contralateral sides (P < 0.05). However, there was no significant difference in OBH between the ipsilateral and contralateral sides (p > 0.05). OBH according to HY stage was significantly smaller in HY stage 2–3 groups than in the disease control group (p < 0.001). The correlation analysis between UPDRS III and OBH showed a mild negative correlation (r = -0.32, p = 0.013).

Conclusions

MRI-measured OBH is decreased in iPD regardless of age and sex and may be correlated with the progression of motor symptoms in the iPD.
Optimizing urban bus network based on spatial matching patterns for sustainable transportation: A case study in Harbin, China
Authors: Gao Boya , Liu Jie
Published: October 2024

The rapid economic development and accelerating urbanization have led to a significant mismatch between the urban bus network allocation and the population flow. Therefore, this paper investigates this challenge by exploring the intricate relationship between the population flow dynamics, traffic congestion conditions, and the efficient allocation of bus resources. In response, two key indexes were introduced based on spatial matching patterns to assess the urban bus network: the Population-Bus Match Index evaluates the matching degree between supply and demand, and the Population-Congestion Match Index evaluates the matching degree between utilization and saturation. Additionally, two distinct optimization strategies have been proposed to enhance the urban bus network. The first optimization strategy considers the bus network’s current status, while the second aspires to an idealized scenario. Subsequently, the potential contributions of each bus station in reducing CO2 emission reduction after implementing the two optimization strategies are quantified. Utilizing a case study focused on Harbin, the proposed methods are validated. The findings unveil a substantial misalignment between supply and demand within the bus network during peak periods, with nearly half of the bus stations experiencing a disparity between utilization and saturation. Comparative experiments across different optimization strategies reveal that the second optimization strategy significantly outperforms the first, but the first optimization strategy has a higher degree of CO2 emission reduction contribution. The results of this study provide decision-makers with an environmentally oriented vantage point for the discerning selection of optimization strategies and leave valuable insights for urban areas confronting transportation challenges.
Balancing acts: The posttranslational modification tightrope of flavivirus replication
Authors: Boytz RuthMabel , Laurent-Rolle Maudry
Published: October 2024

Posttranslational modifications (PTMs) such as phosphorylation, ubiquitination, SUMOylation, and ISGylation are involved in various cellular pathways, including innate immunity and disease processes. Many viruses have developed sophisticated mechanisms to modulate these host PTMs, either by inhibiting the interferon pathway or by enhancing the stability and function of viral proteins essential for replication. In this Pearl, we review the literature on how flaviviruses are impacted by and exploit posttranslational modifications to their advantage.
Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens
Authors: Reyes Raphael A. , Turner Louise , Ssewanyana Isaac , Jagannathan Prasanna , Feeney Margaret E. , Lavstsen Thomas , Greenhouse Bryan , Bol Sebastiaan , Bunnik Evelien M.
Published: October 2024

Plasmodium falciparum infections elicit strong humoral immune responses to two main groups of antigens expressed by blood-stage parasites: merozoite antigens that are involved in the erythrocyte invasion process and variant surface antigens that mediate endothelial sequestration of infected erythrocytes. Long-lived B cells against both antigen classes can be detected in the circulation for years after exposure, but have not been directly compared. Here, we studied the phenotype of long-lived memory and atypical B cells to merozoite antigens (MSP1 and AMA1) and variant surface antigens (the CIDRα1 domain of PfEMP1) in ten Ugandan adults before and after local reduction of P. falciparum transmission. After a median of 1.7 years without P. falciparum infections, the percentage of antigen-specific activated B cells declined, but long-lived antigen-specific B cells were still detectable in all individuals. The majority of MSP1/AMA1-specific B cells were CD95+CD11c+ memory B cells, which are primed for rapid differentiation into antibody-secreting cells, and FcRL5-T-bet- atypical B cells. On the other hand, most CIDRα1-specific B cells were CD95-CD11c- memory B cells. CIDRα1-specific B cells were also enriched among a subset of atypical B cells that seem poised for antigen presentation. These results point to differences in how these antigens are recognized or processed by the immune system and how P. falciparum-specific B cells will respond upon re-infection.
Simulation of the growth and yield of the species Gmelina arborea Roxb
Authors: Alonso Tunjano Jairo , Orejuela Cabrera Juan Pablo , Hernández Pérez Germán Jairo
Published: October 2024

Forests are being threatened worldwide mainly due to the increase in demand for wood and that more than 50% is extracted from them. This is largely because forest plantations grow at a slow rate and supply the market. Given that, one of the fundamental goals of forestry research is the construction of growth and yield models to be used as a planning tool. In this way, the proposal of this work is to show how through the modeling and simulation of the growth of a forest stand, the uncertainty of investors is reduced because it allows to quantify the production of wood that will be obtained. The study was based on data obtained from inventories conducted between 2012 and 2015 in 31 permanent plots of Gmelina arborea Roxb., located in three municipalities of Tolima: Armero, Coello, and Guamo. Based on the inventory data, three regression models were implemented. These results will be particularly useful for silvicultural management planning since the implemented methodology can be applied in other regions of the world and with other varieties of forest species. As an additional stimulus for investors, in the simulation it is possible to quantify carbon capture in a technical way to be offered in the carbon bond market.
THE DEVELOPMENT OF THE ICT SECTOR AND THE DIGITAL TRANSFORMATION IN REGIONAL ECONOMIES
Authors: Lyaskovskaya Elena , Grigorieva Kristina
Published: October 2024

The development of the digital economy and the transition from Industry 4.0 to Industry 5.0 characterize modern societies, which are being transformed by digital technologies. These changes affect socio-economic and organizational-managerial processes, and the state of industries and the mar-kets of national economies. However, the labor market and the ICT sector are undergoing the most sig-nificant changes. The relationships between the characteristics of the labor market, the development of the ICT sector and the digitalization of the economy are complex, ambiguous, and mediated by different influences. This work compares the ICT sector and the digitalization of organizations in Russian re-gions, studies the relationships between them, and determines the trends and features of their develop-ment. The hypothesis of the study is that the development of the ICT sector is determined by the use of digital technologies in regional organizations. The study uses ANOVA and correlation-regression anal-ysis. Data from the Federal State Statistics Service, HSE University, and reports of the International In-stitute for Management Development were used. The results clarify the categorical apparatus in the digitalization of the economy; the role of the ICT sector in digital competitiveness; analyze the digitali-zation of the Russian economy; and determine the essential relationships between digitalization and the development of the ICT sphere in Russian regions in the context of exogenous and endogenous causes of digital transformation, prosumerization, and the service paradigm. A methodological approach to as-sessing the development of the ICT sector due to the digitalization of organizations has been developed, including a system of factors and indicators characterizing the use of digital technologies in organiza-tions and the proportion of those employed in the ICT sector. A distinctive feature of the approach is the comprehensive assessment of the interrelations and interdependence of ICT sector development and digitalization at the macro, meso, and micro levels. The relationship between the digitalization of organ-izations and the ICT sector can be diametrically opposed in Russian regions characterized by the equal-ly high efficiency of regional digital strategies. In this regard, the expediency of the “differential man-agement” of digital processes in Russian regions is substantiated. The results can be used to improve public policy and to activate the digital transformation of regional economies.
AN ASSESSMENT OF THE FUNCTIONAL PURPOSE OF AN ORGANIZATION'S ASSETS
Authors: Galazova Marina
Published: October 2024

This article develops tools for assessing the functional purpose of an organization’s as-sets. It assumes the distribution of financial indicators characterizing the functional role of assets by phases of the economic cycle, taking into account the professional judgment of specialists. The assess-ment of assets is a key element in the financial management of an enterprise, especially in an unstable economic cycle. The hypothesis of the study is based on determining the expediency in assessing the purpose of assets to choose indicators characterizing the financial condition of organizations in different phases of the economic cycle. The study revealed that assets of commercial organizations measure the value of the organization's business turnover; characterize the accumulated potential; help in achieving sustainable capital formation; protect against the risk of liquidity loss by highly liquid assets exceeding the minimum mark, guaranteeing the safety margin of equity; influence the level of risky; and assess its financial condition. A methodological toolkit for assessing the functional purpose of assets has been de-veloped, which assumes the distribution of financial indicators characterizing the functional role of as-sets in different phases of the economic cycle taking into account the professional judgment of special-ists. It is only possible to evaluate the asset management of commercial organizations practically, which will determine the direction of subsequent research.
FORMS OF EMPLOYMENT IN THE CONTEXT OF DIGITALIZATION
Authors: Reznikova Olga , Tsygankova Inga
Published: October 2024

This paper analyzes the new forms of employment in Russia in the context of the digitaliza-tion of the economy and considering macroeconomic indicators to determine the sustainable employment of the population. The study analyzes the features of employment in the context of the digital transformation, including by groups of workers in the information and communication technology (ICT) industries. The hypothesis is that the digital transformation has both a positive and a negative impact on employment; structuring the indicators of employment will allow us to assess the scale of employment and the impact of new forms of employment that require the use of digital technologies. The article uses system analysis and statistical methods of data analysis. The authors show that changes in employment are caused by the transi-tion to more complex types of activity using digital technologies, which changes the forms of employment. It is recommended to assess the situation in the labor market in conjunction with an analysis of the ICT sec-tor to reveal new forms of employment that have developed due to the digitalization of the economy. The authors supplemented the classification of employment indicators, data reflecting the number and parame-ters of employees using digital platforms, and organizations using remote workers. The level of staff train-ing in the digital economy, and employment and wage indicators were analyzed by: the ICT sector as a whole; telecommunications; the production of ICT systems; wholesale trade in goods related to ICT; other services in the field of ICT. It was concluded that digital tools can create opportunities for supporting and developing sustainable employment in remote and virtual forms of work allowing the development of key areas of labor market regulation. A set of measures for digital transformation indicators was proposed.
Suggestion on the elderly care model specific to Türkiye
Authors: Görecek Permin , Acuner Deniz
Published: October 2024

The world population is aging as a result of increasing life expectancy and decreasing birth rates. Since Turkey is among the fastest aging countries in the world, social aging is expected to emerge as a significant problem in the coming years. This research is a qualitative study conducted to determine suggestions for creating an elderly care model specific to Turkey. In this context, in-depth interviews were conducted face to face or online with eight participants providing elderly care services and seven participants receiving the service. Participants were determined by snowball sampling method. Semi-structured questionnaires were used as data collection tools and the obtained data were analyzed using the MAXQDA computer program. The expressions used by the participants in the interviews were coded 306 times under 86 headings and collected under four themes. "Health services provided to the elderly" was the theme with the most codes (33.01%). “Care services for the elderly” was coded 92 times (30.07%), “Social services and social assistance for the elderly” was coded 76 (24.84%) and “Financing, social security system and legal regulations” was coded 37 (12.09%) times. . As a result of the research, suggestions were made for the elderly care model specific to Turkey to improve the health system offered to the elderly, strengthen the social security system, improve care services for the elderly and strengthen social services and social assistance for the elderly.
(Extended English summary is at the end of this document)
 
Özet
Yaşam süresinin uzaması ve doğum oranlarının düşmesi sonucunda dünya nüfusu yaşlanmaktadır. Türkiye, dünyada en hızlı yaşlanan ülkeler arasında yer aldığı için gelecek yıllarda toplumsal yaşlanmanın önemli bir problem olarak ortaya çıkması beklenmektedir. Bu araştırma, Türkiye’ye özgü yaşlı bakım modeli oluşturulmasına yönelik öneriler belirlemek amacıyla yapılan niteliksel bir çalışmadır. Bu kapsamda yaşlı bakım hizmeti sunan sekiz ve hizmeti alan yedi katılımcı yüz yüze ya da online olarak derinlemesine görüşme gerçekleştirilmiştir. Katılımcılar kartopu örnekleme yöntemi ile belirlenmiştir. Veri toplama aracı olarak yarı yapılandırılmış soru formları kullanılmış ve elde edilen veriler, MAXQDA bilgisayar programı kullanılarak analiz edilmiştir. Görüşmelerde katılımcıların kullandıkları ifadeler 86 başlık altında 306 kez kodlanmış ve dört tema altında toplanmıştır. “Yaşlılara sunulan sağlık hizmetleri” en çok kod içeren tema olmuştur (%33,01). “Yaşlılara yönelik bakım hizmetleri” 92 (%30,07), “Yaşlılara yönelik sosyal hizmetler ve sosyal yardımlar” 76 (%24,84) ve “Finansman, sosyal güvenlik sistemi ve hukuki düzenlemeler” 37 (%12,09) kez kodlanmıştır. Araştırma sonucunda, Türkiye’ye özgü yaşlı bakım modeli için yaşlılara sunulan sağlık sistemini iyileştirilmesi, sosyal güvenlik sistemini güçlendirilmesi, yaşlılara yönelik bakım hizmetlerinin iyileştirmesi ve yaşlılara yönelik sosyal hizmetler ve sosyal yardımları güçlendirmesine yönelik önerilerde bulunulmuştur.
Influence of different rootstocks on the characteristics of Vermentino wines at altitudes in Santa Catarina
Authors: Nardello Izabel Camacho , Batalha Moreno Kirinus Marines , de Souza André Luiz Kulkamp , Caliari Vinícius , Malgarim Marcelo Barbosa
Published: October 2024

The objective of this study was to determine the best rootstock that enhances the enological characteristics of the Vermentino grape variety cultivated in the high-altitude region of Santa Catarina, Brazil, over three vintages (2018, 2019, and 2020). Four rootstocks were evaluated: '101-14 Mgt', 'Harmony', 'Paulsen 1103', and 'VR 043-43'. The physicochemical and sensory properties of the wines were assessed. The findings revealed that the rootstocks '101-14 Mgt', 'Harmony', 'Paulsen 1103', and 'VR 043-43' produced wines with the lowest total acidity in the 2019 vintage. The alcohol content was notably lower in wines produced with 'VR 043-43' in 2021. Sensory analysis indicated that wines made with the '101-14 Mgt' and 'Harmony' rootstocks in the 2019 vintage exhibited higher turbidity. The herbaceous character was most pronounced in the 2019 vintage, with a stronger herbaceous aroma regardless of the rootstock used. Acidity levels were highest in the wines from the 2021 vintage, particularly in those made with the 'Harmony' and 'VR043-43' rootstocks.
Virulence characterization of Staphylococcus spp. isolated from mozzarella cheeses and cheese-slicers
Authors: Erundina de Luna Moraes Leite Ana , Lira de Araújo Kallyane , Sequeira Mendonça Karla , Pinheiro Franque Marcos , Rodrigues da Silva Elizabete , Mendonça Marcelo , Sampaio de Medeiros Elizabeth
Published: October 2024

Different species of the Staphylococcus genus can be found as contaminants in foods and may carry virulence factors that could potentially make them The enterotoxigenic potential ofpathogenic or transfer genes to other bacteria. Therefore, the aim of the present study was to isolate and identify species of Staphylococcus genus isolated from sliced mozzarella cheeses and cold-cut slicers and characterize biofilm formation in vitro, presence of enterotoxins and antibiotic resistance genes, and β-lactamase production. Sampling was carried out in 44 retail markets and isolates identified on species level. Resistance genes blaZ and mecA, as well as enterotoxin genes sea, seb, sec, and sed, were identified using PCR. Phenotypic evaluation of biofilm formation and detection of β-lactamase enzyme were also analyzed. Nine species of coagulase-negative Staphylococcus (CNS) were identified from 85 bacterial isolates. Of this total, 67.0% were positive for the presence of one or both antimicrobial resistance genes blaZ and mecA, while the β-lactamase enzyme was detected in 52.9% isolates. Regarding biofilm production, 48.2% of isolates were positive and 51.8% were negative. However, none of the isolates were identified with the enterotoxin genes. The results demonstrate the potential risk of cross-contamination, as biofilm-producing CNS could persist in the cheese retail environment, highlighting the danger of resistance genes transferring to other commensal or pathogenic bacteria.
Prediction of the potential Brazilian distribution for invasive mollusc Melanoides tuberculata (Müller, 1774), including a new record from Northern Coastal Region
Authors: CARVALHO MAYARA CAROLYNE MOURÃO , ABREU ALDEANE SOARES DE , SILVA MAURICIO SANTOS DA , CANTANHEDE SELMA PATRICIA DINIZ , MONROE THERCIA GONÇALVES RIBEIRO , ARAÚJO LUDMILA SEREJO , TCHAICKA LIGIA
Published: October 2024

The freshwater snail Melanoides tuberculata (Müller, 1774) native from Africa and Asia, recently spreads out over the world. Records of invasive species are extremely important, because it helps in future invasions mitigation. Here, we report for the first time the occurrence of M. tuberculata in a protected area of Northern Brazilian Coast and use predictive distribution modeling to know the potential Brazilian distribution for this species. The gastropod M. tuberculata were collected in the municipalities of Tutóia and Santo Amaro - Maranhão State. According to the results of the predictive map distribution for Brazil, the regions with the highest susceptibility are the northeast, southeast and midwest. Preciptation of month and Isothermalithy were de variables that most contribute to the species’ potential distribution.  This species presented high to medium suitability of occurrence in 32 national protected areas. Futher studies are recommended to monitor the growth and dispersion, in order to determine its real impact.
Crystal structure of (E)-2-(4-(1H-imidazol-1-yl)benzylidene)-7-fluoro-3,4-dihydronaphthalen-1(2H)-one, C20H15FN2O
Authors: Chen Yu , Wang Ji-Peng , Wang Mei-Dan , Yu Wen-Xiao , Cui Yao-Tian , Gao Hao-Xue , Hou Gui-Ge , Ren Yan
Published: October 2024

C20H15FN2O, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 8.0724(1) Å, b = 9.6473(1) Å, c = 9.6635(1) Å, α = 80.903(1)°, β = 82.325(1)°, γ = 84.147(1)°, V = 733.922(14) Å3, Z = 2, Rgt
(F) = 0.0366, wRref
(F
2) = 0.0934, T = 293 K.
The co-crystal structure of 4-chlorobenzophenone–salicylhydrazide(1/1), C20H17ClN2O3
Authors: Wang Ji , Wu Wenhui , Zhang Wencai , Yang Xiying , Qiao Jie
Published: October 2024

C20H17ClN2O3, triclinic, P

1
‾

$\overline{1}$

(no. 2), a = 6.2486(3) Å, b = 7.4746(4) Å, c = 19.0245(10) Å, α = 89.341(2)°, β = 85.998(2)°, γ = 83.651(2)°, V = 880.94(8) Å3, Z = 2, R
gt(F) = 0.0351, wRref
(F
2) = 0.0970, T = 289 K.
The crystal structure of the co-crystal composed of benzhydrazide and 5-aminoisophthalic acid, C8H7NO4⋅C7H8N2O
Authors: Bourletidis How Jeraldine Maire , Scheepers Matthew C. , Lemmerer Andreas , Smith Mark G.
Published: October 2024

C8H7NO4⋅C7H8N2O, monoclinic, P21/n (no. 14), a = 18.3690(6) Å, b = 3.8010(1) Å, c = 21.5232(7) Å, β = 108.867(1)∘, V = 1422.02(8) Å3, Z = 4, R

gt
(F) = 0.0340, wR

ref
(F
2) = 0.0959, T = 173 K.
Crystal structure of (3,6-di(2-pyridyl)-4-phenylaminopyridazine-κ2N,N′)-bis(2-(p-toluene)pyridinyl-κ2C,N)-iridium(III) hexafluorophosphate –dichloromethane (1/1), C45H37Cl2F6IrN7P
Authors: Qian Jun , Ma Liang , Wang Yida
Published: October 2024

C45H37Cl2F6IrN7P, monoclinic, P21/c (no. 14), a = 23.518(5) Å, b = 11.702(2) Å, c = 15.426(3) Å, β = 101.44(3)°, V = 4161.0(15) Å3, Z = 4, R

gt
(F) = 0.0474, wR

ref
(F
2) = 0.0924, T = 293 K.
Current advancements in PD-L1 modulation by CMTM6 in malignant tumors
Authors: Zhang Lisha , He Sisi , Wu Lixing , Wang Xiangqin , Bai Yuju
Published: October 2024

The CKLF-like MARVEL transmembrane domain-containing protein 6 (CMTM6), a member of the chemokine-like factor superfamily, binds to programmed death-ligand 1 (PD-L1) on the cell membrane, thereby impeding PD-L1’s lysosomal degradation and sustaining its expression. In recent years, extensive studies on PD-L1 have provided insights into its function as an immunepoint inhibitor involved in tumor cell immune evasion. The specific interaction between CMTM6 and PD-L1 suggests a potential role in tumor cell immune evasion and suppression, potentially offering a novel therapeutic target for cancer immunotherapy. Currently, the research on CMTM6 and PD-L1 in diverse tumors and diseases is limited, but their significant roles are indicated. This article provides an overview of the impact of CMTM6 on the immune microenvironment in different types of cancer (such as lung cancer, breast cancer, and liver cancer), and summarizes the effects of CMTM6 on the occurrence and development of various tumors.
Comparative Analysis of Six Adeno-Associated Viral Vector Serotypes in Mouse Inferior Colliculus and Cerebellum
Authors: Witteveen Isabelle , Balmer Timothy
Published: October 2024

Adeno-associated viral vector (AAV) serotypes vary in how effectively they express genes across different cell types and brain regions. Here we report a systematic comparison of the AAV serotypes 1, 2, 5, 8, 9, and the directed evolution derived AAVrg, in the inferior colliculus (IC) and cerebellum. The AAVs were identical apart from their different serotypes, each having a synapsin promotor and expressing GFP (AAV-hSyn-GFP). Identical titers and volumes were injected into the IC and cerebellum of adult male and female mice, and brains were sectioned and imaged 2 weeks later. Transduction efficacy, anterograde labeling of axonal projections, and retrograde labeling of somata were characterized and compared across serotypes. Cell-type tropism was assessed by analyzing the morphology of the GFP-labeled neurons in the cerebellar cortex. In both the cerebellum and IC, AAV1 expressed GFP in more cells, labeled a larger volume, and produced significantly brighter labeling than all other serotypes, indicating superior transgene expression. AAV1 labeled more Purkinje cells, unipolar brush cells, and molecular layer interneurons than the other serotypes, while AAV2 labeled a greater number of granule cells. These results provide guidelines for the use of AAVs as gene delivery tools in these regions.
Un nouveau cas de rétinopathie diabétique proliférante chez un patient atteint de dystrophie cônes-bâtonnets
Authors: Yan Keying , Zhou Zimei , Eleff Tybee
Published: October 2024

La rétinopathie diabétique et les dystrophies rétiniennes sont rarement concomitantes en raison de l’effet protecteur des dystrophies rétiniennes contre la rétinopathie diabétique, et il existe peu de documentation sur la concomitance de la rétinopathie diabétique et des dystrophies rétiniennes. Ce rapport décrit un cas rare de rétinopathie diabétique proliférative chez un patient atteint de dystrophie cônes-bâtonnets. Cette coexistence n’est pas seulement unique dans sa présentation, elle souligne également le rôle important des tests auxiliaires, notamment l’autofluorescence du fond de l’œil, l’angiographie par fluorescéine, la tomographie par cohérence optique et l’électrorétinogramme plein champ. Les tests génétiques peuvent également faciliter le diagnostic. La pathophysiologie du développement concomitant de ces troubles est abordée. Ce cas souligne la nécessité d’approfondir les recherches sur la pathophysiologie de la rétinopathie diabétique, en particulier chez les patients qui ont une dystrophie rétinienne.
Efficacité des conférences d’éducation publique liées à la vision
Authors: Labreche Tammy , Irving Elizabeth
Published: October 2024

Contexte : L’éducation publique digne de confiance est jugée essentielle pour garantir que la population canadienne reçoive des soins oculovisuels opportuns, uniformes et complets. Les conférences de sensibilisation du public sont une méthode de diffusion de cette information. Le but de cette étude était de déterminer l’efficacité de ces conférences pour atteindre leurs objectifs éducatifs.
Méthodes : Un sondage préalable et postérieur a été créé et diffusé lors d’une conférence d’éducation publique organisée par le Centre for Sight Enhancement. Les questions du sondage portaient sur la perception des connaissances acquises, les attitudes à l’égard de la présence de symptômes de maladie oculaire et l’importance des examens de la vue.
Résultats : Sur les 74 personnes participantes, 27 ont répondu au sondage préalable et 24 ont répondu au sondage après la conférence. Il y a eu une augmentation statistiquement significative des connaissances perçues acquises dans tous les secteurs de conférence. Il n’y a pas eu d’amélioration statistiquement significative de la sensibilisation à la nature asymptomatique des maladies oculaires précoces ou à l’importance des examens de la vue.
Conclusion : Les conférences d’éducation du public sont une méthode efficace de diffusion des connaissances sur les soins oculovisuels, mais il faudra effectuer d’autres recherches pour déterminer si elles peuvent aider à modifier les tendances de recherche de soins oculovisuels.
La miniatura románica en España: estado de la cuestión
Authors: Yarza Luaces Joaquín
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
Barthélemy d'Eyck y el Retablo de la Virgen de Belén en Laredo
Authors: Polo Sánchez Julio Juan , Aramburu-Zabala Higuera Miguel Ángel
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
Sobre el Castillo de la Calahorra y el Codex Escurialensis
Authors: Marías Franco Fernando
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
La nueva arquitectura de la Universidad Autónoma en Cantoblanco (Madrid)
Authors: Urrutia Núñez Ángel
Published: October 2024

Anuario del Departamento de Historia y Teoría del Arte
Reflexiones sobre la platería española en la segunda mitad del siglo XV: sobre dos cruces conservadas en el Instituto de Valencia de Don Juan y en el Museo del Camino de Astorga
Authors: Martín Ansón María Luisa
Published: October 2024

Las artes de la orfebrería y esmaltería tuvieron un gran desarrollo durante el siglo XIV en la Corona de Aragón. En el siglo XV la platería barcelonesa se desliga de la levantina. Al mismo tiempo surge de nuevo la orfebrería castellana. El menor conocimiento de esta última se debe, en parte, a la falta de punzón, a pesar de la obligatoriedad de marcar las piezas, dictadas en las Cortes de Madrid de 1435, bajo Juan II. Con el estudio de estas dos cruces procesionales ("Instituto Valencia de D. Juan de Madrid y Museo del Camino de Astorga") se trata, modestamente, de analizar la confluencia de elementos catalanes y castellanos en unas piezas que responden a los planteamientos artísticos de la segunda mitad del siglo XV.
Las Exposiciones públicas de los productos de la industria española en el Madrid fernandino
Authors: López Castán Ángel
Published: October 2024

Las Exposiciones públicas de los productos de la Industria Española celebradas en Madrid a partir de 1827 constituyen, junto con la fundación del Real Conservatorio de Artes (1824), uno de los factores determinantes en el desarrollo de las artes decorativas madrileñas de los últimos años del reinado de Fernando VII (1814-1833), tras la profunda crisis originada por la Guerra de la Independencia. Las "Memorias" de las Exposiciones de 1827, 1828 y 1831 informan detalladamente sobre los diferentes premios -medallas de oro, plata y bronce-, artífices y piezas galardonados en estos certámenes.
Delacroix y la angustia ante los maestros
Authors: Solana Guillermo
Published: October 2024

Los escritos de Delacroix -diarios, ensayos y cartas reflejan la angustia del pintor ante los maestros del pasado. Delacroix siente su propia originalidad amenazada por el prestigio de sus grandes precursores y teme que la historia del arte no sea sino un constante declive. Para degradar a los maestros -David, Rubens, Rafael- Delacroix los muestra como imitadores. Para vindicar al artista moderno, por otra parte, Delacroix propone juzgarlo no por sus débiles resultados sino por la medida de sus esfuerzos. El genio es energía personal, audacia (hardiesse). Por su fe y coraje el artista tardío puede escapar finalmente al destino de la decadencia y llegar a "crearse a sí mismo".
Apuntes sobre Francisco Lameyer
Authors: Palacios López María Dolores
Published: October 2024

En el presente artículo el interés fundamental ha estado centrado en ciertos aspectos de la vida de Lameyer que hemos entresacado de un documento de gran importancia y que es el "Informe de la Armada" del Archivo Museo de la Marina de Guerra "Don Álvaro de Bazán"en el Viso del Marqués (Ciudad Real); en este documento encontramos toda la información sobre Francisco Lameyer en el período en el que fue funcionario en el cuerpo de la Armada. Esta actividad laboral explica ciertas cuestiones que afectan a su personalidad como artista. Un dato que nos parece también fundamental es su labor como restaurador que desempeñó gratuitamente en el Museo de la Armada; este desinterés económico se ve en gran parte de su actividad artística.
El Buen Retiro y el Conde Duque de Olivares
Authors: Chaves Montoya María Teresa
Published: October 2024

La transformación en el magnífico conjunto arquitectónico-paisajístico del Buen Retiro de lo que en un principio iba a ser sólo una remodelación del Cuarto Real de San Jerónimo se debió al empeño del Conde Duque de Olivares por crear un palacio digno del más grande de todos los monarcas de su tiempo, al igual que sus regios antepasados habían invertido dinero y esfuerzos en fábricas que ya siempre permanecerían unidas a su memoria. Nuestra intención al presentar algunos episodios y nuevos datos documentales relativos a los inicios de la construcción del nuevo palacio -como la primera descripción conocida hasta ahora y escrita en el momento preciso de su inauguración- , es la de recordar, apoyando o rebatiendo, los argumentos que el Conde Duque tuvo que oponer a las acerbas críticas lanzadas contra su obra, y subrayar el protagonismo de los miembros integrantes del escogido círculo de Olivares que, en el plano artístico, financiero y administrativo, hicieron posible su realización.
Francisco Rizi y Claudio Coello: a propósito de la anécdota de Palomino sobre el Retablo de la Parroquia de Santa Cruz de Madrid
Authors: Gutiérrez Pastor Ismael
Published: October 2024

El objeto de este artículo es plantear algunas cuestiones en torno a la pintura madrileña de la segunda mitad del siglo XVII que probablemente nunca lleguen a ser resueltas satisfactoriamente. Francisco Rizi, Claudio Coello y Antonio Palomino, unidos en torno al retablo de la parroquia de Santa Cruz de Madrid, suscitan algunas dudas y sospechas sobre sus comportamientos profesionales, tomando como punto de partida sus propias obras, los documentos y la historiografía artística.
Los conflictos sobre competencias entre académicos y no académicos en las postrimerías del siglo XVIII: el recurso del escultor Juan Pedro Guisart contra el tallista José Navarro David
Authors: De la Peña Velasco María Concepción
Published: October 2024

La rivalidad entre los artistas formados en las Academias de Bellas Artes con los maestros cuyo aprendizaje partió de los talleres artesanales patentiza uno de los problemas más controvertidos que tuvo lugar a finales del siglo XVIII en España. Forzados a convivir en una época en que los académicos abusaban de su título y los gremios luchaban por mantener su ya mermado poder, se produjo una lenta y difícil aceptación de las novedades impuestas por unas normas oficiales que marcaban claramente las diferencias entre quienes practicaban un arte liberal y mecánico. En este contexto se sitúa el pleito de Guisart, escultor académico de mérito por San Carlos de Valencia, contra los tallistas murcianos liderados por Navarro David que concluyó con un dictamen favorable a estos últimos por parte de la Academia de San Fernando, cuyo contenido fue explicado en un copioso memorial por lsidoro Bosarte, como secretario de esta institución.
Arte e industria en el Madrid del siglo XVIII
Authors: López Castán Ángel
Published: October 2024

El presente trabajo trata de determinar las relaciones existentes entre arte e industria en el Madrid del siglo XVIII. Al análisis, contradictorio a veces, de los conceptos "obrador-taller" y "fábrica-manufactura" sigue una enumeración de las principales fábricas, talleres y escuelas de arte decorativo establecidas en la Corte a lo largo del siglo XVIII, consignándose, además de su localización urbana, el año de fundación y los nombres de sus respectivos directores artísticos.
La pregunta por la expresión en el estilo: Gombrich y Wölfflin
Authors: Arnaldo Alcubilla Francisco Javier
Published: October 2024

Como es sabido, la obra de Wölfflin es una importante referencia en la formación y en los escritos de Gombrich, a la vez que objeto de una crítica contundente por parte de éste. Gombrich abunda en el desarrollo autónomo de los problemas artísticos iniciado por Wölfflin, e incluso da explicación a algunas constantes del comportamiento formal postuladas por el autor de "Conceptos fundamentales". El punto de partida de ambos es la psicología de la percepción, sólo que esta ciencia se ha desarrollado extraordinariamente en nuestro siglo, y ha puesto en evidencia la necesidad de revisar, entre otras cosas, los criterios para la interpretación de los estilos artísticos que se derivaban de la psicología de la empatía del siglo XIX. La antropología biológica de Gombrich ha puesto las bases de una evaluación más adecuada de la relación estilo-expresión.
Sobre la cronología y el autor de la imagen románica de Santa María la Real de Irache (Navarra)
Authors: Martínez de Aguirre Javier
Published: October 2024

La cita de un orfebre de nombre Rainalt como testigo destacado en un documento del Becerro de Irache (Navarra) lleva al autor a proponer que estamos ante la mención del artista creador de la estatua de Santa María la Real, obra maestra de la imaginería románica mariana que, procedente de dicho monasterio, custodia hoy la parroquia de Dicastillo. Las circunstancias favorables, especialmente la abundancia de recursos económicos, la probada existencia de plata (necesaria para el revestimiento característico de la imagen), la colaboración del monarca García Ramírez (1134-1150) y la probable finalización de la cabecera románica del templo apoyan la cronología propuesta, hacia 1145. La calidad de la escultura y sus peculiaridades formales (el nudo de la toca) apuntan hacia un cualificado orfebre ultrapirenaico, procedencia acorde con el nombre Rainalt, probablemente languedociano o italiano. De confirmarse la hipótesis estaríamos ante una de las escasas vírgenes románicas de autor y fecha conocidos.