bluuebunny/crossref_metadata_2025 huggingface dataset:
Readymade Code: Braille in Contemporary Visual Culture
Authors: Warne Vanessa
Published: September 2018

This essay examines the proliferation of enlarged braille as a design element in contemporary culture. Exploring the relationship between the enlargement of braille and the use of braille as a code, I explore the cultural appropriation of braille by sighted creators who are not interested in blind people's reading and writing experiences but who value instead the temporary obfuscation of written messages created for sighted people. The essay also discusses two art installations noteworthy for their tactical use of enlarged braille to critique the ocularcentrism of contemporary culture, a culture that is actively repurposing braille as a puzzle for sighted people to solve.
Rivoluzioni visuali, in forma di cosa: cronaca di un evento (in)tempestivo
Authors: Colucci Dalila
Published: September 2018

Simposio internazionale Poesia in forma di cosa. Concretismo e Visualità in Italia e Belgio negli anni Sessanta e Settanta – Istituto Italiano di Cultura di Bruxelles, 24-25 maggio 2018.
Etnograficzny portret publiczności warszawskich wyścigów konnych
Authors: Bossak-Herbst Barbara
Published: September 2018

Tekst zawiera portret stałej publiczności wyścigów konnych na Torze Służewiec w Warszawie. W oparciu o materiały zebrane podczas długotrwałej obserwacji etnograficznej scharakteryzowana została subkultura stałych uczestników mitingów wyścigowych, ich zachowania przestrzenne, niewerbalne i językowe. Kategorie uwrażliwiające zaczerpnięte z dorobku Ervinga Goffmana pozwoliły wyeksponować uwzorowania ich zachowań. Publiczność wyścigowa nigdy dotąd nie była przedmiotem dociekań badaczy społecznych w Polsce. Artykuł ukazuje różne płaszczyzny, na których można zarysować typologię współczesnych stałych i regularnych bywalców Toru Służewiec. Punktem odniesienia dla niej były badania etnograficzne bywalców wyścigowych Kate Fox w Wielkiej Brytanii oraz Johna Rosecrance w Stanach Zjednoczonych. Osią tekstu jest teza, iż Tor Służewiec jest wyjątkową niszą społeczną zdominowaną przez przeważnie starszych mężczyzn, którzy poprzez zrytualizowane i wymagające zaangażowanie uczestniczą w hazardzie, znajdują swoją podmiotowość i poczucie przynależności.
Girls in Football, Boys in Dance. Stereotypization Processes in Socialization of Young Sportsmen and Sportswomen
Authors: Jakubowska Honorata , Byczkowska-Owczarek Dominika
Published: September 2018

The article at hand presents and discusses the issue of gender stereotypization strategies during the socialization process of children practicing atypical gender sports, which is perceived as inappropriate to their gender. The outcomes of two qualitative studies among girls playing football and boys practicing ballroom dancing focus on various types of social influence of their families, coaches, and peers. The importance of parents’ role in reproducing or challenging stereotypical gender roles is outlined in the text. The strategies to which the children participating in atypical gender sports are subjected to include: stereotypization, destereotypization, apparent destereotyping, and hidden stereotyping. The benefits of participating in atypical gender sports are also discussed, particularly in terms of social and psychological profits.
Body on the Plate. On the Relation between the Carnality and Food (on the example of meat in advertising)
Authors: Goszczyński Wojciech , Wójtewicz Anna
Published: September 2018

Do we own our bodies? Do we control them during the meal, or does the meal control us? In this paper, we aim to examine the complex nexus of social and physical practices embedded in eating habits. During the examination of selected culinary advertisements, we will attempt to explain how food stabilizes, catalyzes, separates, and mediates social relations, as well as social and individual bodies. The paper merges the perspective of cultural anthropology, sociology of the body, and food studies.
Research into Transformations in Everyday Life: Three Methodological Notes
Authors: Kubátová Helena
Published: September 2018

The article focuses on the reflection of my research experience in obtaining qualitative data using narrative interviews. I confronted my own research experience with the phenomenological methodology of Alfred Schütz, dramaturgical sociology of Erving Goffman, and interpretative sociology of Max Weber. The article discusses three problems that emerged during a longitudinal study of everyday life transformation in the long-term horizon of sixty years: 1. How to create a concept of everyday life so it serves not only as a tool for collecting, analyzing, and interpreting data, but also as a tool for understanding the meanings of the examined empirical world; 2. How to discursively create an image of everyday life transformations during an interview between a participant and a researcher and what it means in relation to the research subject; 3. How to reach understanding between the participant and the researcher during a face-to-face interview.
Community Immersion, Trust-Building, and Recruitment among Hard to Reach Populations: A Case Study of Muslim Women in Detroit Metro Area
Authors: Mohebbi (Mehrsa) Mehri , Linders Annulla , Chifos Carla
Published: September 2018

Scholars have identified a range of factors that influence the ability of researchers to access hard-toreach groups and the willingness of their members to participate in research. In this paper, we draw on insights from both ethnographic methods and participatory action research to demonstrate the importance of building trust in our relationships with hard-to-reach participants in research based on interviews. Such trust-building, we show, is greatly facilitated by pre-recruitment immersion that aids not only the recruitment of individual participants but also improves the quality of the data collected. These methodological concerns emerged from an interview study focusing on Muslim women’s use of urban public recreational spaces in South-East Michigan. Although the first author of this paper, as a woman and a Muslim, is a formal insider in the study population, her experiences with recruitment demonstrate that the access granted by insider status is insufficient as grounds for a research relationship based on trust. This is so especially when the target population is as marginalized and embattled as the post 9/11 immigrant Muslim community. With more than two years of community immersion, however, she was able to foster enough trust to secure a large number of committed participants that spoke freely and thoughtfully about the issues at stake (78 in all).
Special Issue on Active and Passive Vibration Damping in Machine Tools
Authors: Zaeh Michael F.
Published: September 2018

Automation of machine tools has made them more productive, thereby providing an advantage for sustainability and the welfare of mankind. However, in many cases, the successful automation of machine tools requires the avoidance of self-excited chatter vibrations, resulting in a reliable stable state for cutting. Machine tool operators tend to use the machines close to their power thresholds, thereby unknowingly driving them toward the limits of their stability. Much progress has been made in the last few decades concerning the understanding and prediction of such vibrations, and this has led to improvements such as higher cutting rates and chip thicknesses.

Several countermeasures such as active and passive damping are available for avoiding chatter vibrations in machine tools. However, their industrial use is not common yet. In fact, the industry is somewhat unfamiliar with many of these countermeasures. The hesitant attitude of the machine tool builders to apply such countermeasures is a result of several factors: active and passive damping devices are additional system components that require design, tuning, and maintenance. Furthermore, they are associated with a risk of failure, resulting in additional down times of the machines. Additionally, if a machine requires such devices to achieve the desired specifications, the customer’s opinion regarding it can be negatively affected. This situation is challenging for machine tool builders, users, and academia as well. Therefore, we decided to dedicate a special issue of IJAT to this topic.

This special issue focuses on both active and passive damping measures, particularly the measures that are systematically designed and deliberately implemented to increase the chatter-free depth of cut in machine tools. The papers in this issue identify successful applications or at least a vision for them. Additionally, models demonstrating the effects of the chosen active or passive damping systems are presented. Some of these models can also be used to systematically select the parameters of the system. Some of the systems can be easily applied as low-cost patch-up solutions to improve the behaviors of the machines already in use.

I hope that this special issue delivers a valuable overview of the existing approaches to introduce additional damping in machine tools. I would like to sincerely thank all the authors for their dedication and the well written and illustrated manuscripts. I would also like to thank the reviewers for their efforts to ensure the quality of this issue. Finally, I am very thankful to IJAT for their immense cooperation and support. I wish you all the best and hope that you can benefit from the content of this special issue.
Development of an Active Damping System for Structural Chatter Suppression in Machining Centers
Authors: Mancisidor Iker , Beudaert Xavier , Aguirre Gorka , Barcena Rafael , Munoa Jokin ,   Dynamics and Control Department, IK4-Ideko Arriaga industrialdea 2, 20870 Elgoibar, Spain,   Department of Electronic Technology, University of the Basque Country, Bilbao, Spain
Published: September 2018

The presence of chatter vibrations is one of the main limitations of machining processes in terms of productivity, as they prevent obtaining the required surface finishes and decrease the life of tools and the mechanical elements of the machine. The use of active dampers governed by a control strategy permits an increase in structural damping without significantly changing the machine design. The main objective of this study is to improve the dynamic capabilities of the machine, and to increase the chatter-free region. This objective is achieved by the addition of an electromagnetic actuator located as close as possible to the cutting point. The electromechanical design of the actuator is described, and a novel double flexure guarantees a constant gap between the moving magnets and the coils. This smart mechatronic system allows the introduction of new additional functions: process and machine monitoring, chatter avoidance by spindle speed modification, and machine dynamics calibration. All of these functions enhance standard milling machines.
Model-Based Installation of Viscoelastic Damper Support for Reduction of Residual Vibration
Authors: Mori Kotaro , Kono Daisuke , Yamaji Iwao , Matsubara Atsushi ,   Kyoto University Kyotodaigaku-Katsura, Nishikyo-ku, Kyoto 615-8540, Japan,   Japan Society for the Promotion of Science, Tokyo, Japan
Published: September 2018

It is necessary to increase the damping of a machine support structure (support damping) to reduce the residual vibrations caused by rocking vibration. The stiffness of the machine support system (support stiffness) is also an important parameter that needs to be considered while designing machine tools, to avoid low frequency vibrations. However, conventional passive damper supports decrease the support stiffness while increasing the damping. In our previous study, a passive viscoelastic non-linear damper system for shear vibrations, where the vertical preload determines its damping coefficient, was developed to increase the support damping without decreasing the stiffness by focusing on the horizontal component of rocking vibration. The magnitude dependency of the damping capacity has been modeled. However, this damper system has a tradeoff relationship between natural frequency and damping capacity caused by changes in the preload distribution. Thus, adjustment of the vertical preload applied on the damper is essential for the model-based installation of this damper system. So far, no method has been proposed considering this issue. The vertical preload has been adjusted by trial and error methods. This study proposes a method to determine the damper preload conditions systematically by considering the tradeoff relationship between natural frequency and damping capacity caused by changes in the preload distribution. This method is described based on the case study of a machining center. First, the relationship between preload distribution and support stiffness is investigated using the support stiffness model. Then, the relationship between damping capacity and vertical preloads on the damper is investigated based on material test results. Based on these investigations, the tradeoff relationships are simulated on a machining center by utilizing the damper model. The simulation results are verified with the experimental results. The results show that the proposed method can estimate the tradeoff relationship between natural frequency and damping capacity caused by the changes in the preload distribution. By utilizing this estimated relationship, the preferred preload condition can be decided depending upon the user’s demand.
Special Issue on Progress of Manufacturing Technology
Authors: Yamada Keiji , Ohashi Kazuhito , Ishida Tohru , Sugino Tadanori
Published: September 2018

First, we would like to express our sincere condolences to the victims of the landslides and floods caused by the torrential rain in Japan in July 2018. We were terribly grieved to hear about these disasters during the editing of this special issue of the International Journal of Automation Technology (IJAT), and we sincerely hope for the revival of the disaster-stricken areas.

This special issue focuses on the progress in manufacturing technologies for maximizing product quality and reducing costs, especially in the mechanical industry. Manufacturing technologies have been developing in order to meet the changes in social and economic environments such as progress in informatization, diverse needs, and increasing demands for a sustainable society. At present, engineers and researchers in the field of manufacturing are facing an unprecedented rapid change caused by the fourth industrial revolution. Therefore, research in this field is also expected to develop more than ever before.

This special issue of IJAT contains seven research papers on topics including shearing of metal sheets, machine tools and machining technology, precision dimensional measurement, and nanoimprinting process. Some of the papers, revised and extended at the editors’ request, were presented originally at the 9th International Conference on Leading Edge Manufacturing in 21st Century (LEM21), held in Hiroshima, Japan in 2017.

The editors thank the authors and reviewers for their comprehensive efforts in making this special issue possible, and hope that these articles will encourage further research on manufacturing technologies.
Error Estimation of Machined Surfaces in Multi-Axis Machining with Machine Tool Errors Including Tool Self-Intersecting Motion Based on High-Accuracy Tool Swept Volumes
Authors: Arai Wataru ,   Digital Systems and Environments, Division of Systems Science and Informatics,
Graduate School of Information Science and Technology, Hokkaido University Kita 14, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0814, Japan, Tanaka Fumiki , Onosato Masahiko
Published: September 2018

A novel method is proposed for estimating the machining errors on machined surfaces caused by errors of multi-axis machine tools, such as geometric errors, based on a new generating method of tool swept volumes. In the proposed tool swept volume generation method, the boundary surfaces of the tool swept volumes are derived as triangular mesh models satisfying the required approximation accuracy based on the tangency condition. Using the proposed method, tool swept volumes can be derived for various tool paths including the tool self-intersecting motion. A tool path evaluation method based on the error vectors with respect to the start position of a specific tool path is also proposed. In the proposed evaluation method, error vectors on machined surfaces are derived by comparing the points on the nominal tool swept volumes (excluding the machine tool errors) with the triangles on the error tool swept volumes (including the machine tool errors).
Milling Process Monitoring Based on Vibration Analysis Using Hilbert-Huang Transform
Authors: Susanto Agus , Liu Chia-Hung , Yamada Keiji , Hwang Yean-Ren , Tanaka Ryutaro , Sekiya Katsuhiko ,   Graduate School of Engineering, Hiroshima University 1-4-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8527, Japan,   Industrial Technology Research Institute, Hsinchu, Taiwan,   Department of Mechanical Engineering, National Central University, Taoyuan City, Taiwan
Published: September 2018

Vibration analysis is one method of machining process monitoring. The vibration obtained in machining is often nonlinear and of a nonstationary nature. Therefore, an appropriate signal analysis is needed for signal processing and feature extraction. In this research, vibrations obtained in the milling of thin-walled workpieces were analyzed using the Hilbert-Huang transform (HHT). The features obtained by the HHT served as machining-state indicators for machining process monitoring. Experimental results showed the effectiveness of the HHT method for detecting chatter and tool damage.
REQUIREMENTS FOR EFFICIENT PCR CLAMPING BY LOCKED NUCLEIC ACID OLIGONUCLEOTIES FOR SIMPLE AND SENSITIVE DETECTION OF SOMATIC MUTATIONS
Authors: Shamanin V. A. , Karpov I. V. , Pisareva E. E. , Gutkina N. I. , Kovalenko S. P.
Published: September 2018

PCR clamping/wild-type blocking PCR with non-extendable locked nucleic acid (LNA) oligonucleotides is used for sensitive detection of somatic mutations in tumors. Various  versions of the technique use different DNA polymerases and LNA oligonucleotides with and  without additional phosphorothioate modifications. Here we studied requirements for successful  PCR clamping with LNA oligonucleotides and Taq DNA polymerase for analysis of mutations in  KRAS and BRAF genes by means of real-time PCR and Sanger sequencing. We found that  addition of phosphorothioate linkages at the 5’-end of LNA oligonucleotide to protect from 5’- exonuclease activity of Taq DNA polymerase did not improve clamping. For most target  sequences, efficient clamping was observed at melting temperature of LNA oligonucleotide  20‑25°C above annealing/extension temperature of the PCR with a 2-step protocol. Under such  conditions, simple and sensitive detection of mutations in KRAS and BRAF genes was feasible using real-time PCR with TaqMan probes or Sanger sequencing.
COMPARATIVE ANALYSIS OF THE EXOSOMAL CARGO OF THE ESTROGEN-RESISTANT BREAST CANCER CELLS
Authors: Semina S. E. , Barlev N. A. , Mittenberg A. G. , Krasilnikov M. A.
Published: September 2018

The exosomes involvement in the pathogenesis of tumors is based on their property to incorporate into the recipient cells resulting in the both genomic and epigenomic changes.  Earlier we have shown that exosomes from different types of estrogen-independent breast  cancer cells (MCF-7/T developed by long-term tamoxifen treatment, and MCF-7/M)  developed by metformin treatment were able to transfer resistance to the parent MCF-7  cells. To elucidate the common features of the both types of resistant exosomes, the  proteome and microRNA cargo of the control and both types of the resistant exosomes were  analyzed. Totally, more than 400 proteins were identified in the exosome samples. Of these  proteins, only two proteins, DMBT1 (Deleted in Malignant Brain Tumors 1) and THBS1  (Thrombospondin-1), were commonly expressed in the both resistant exosomes (less than  5% from total DEPs) demonstrating the unique protein composition of each type of the resistant exosomes. The comparative analysis of the miRNA differentially expressed in  the both MCF-7/T and MCF-7/M resistant exosomes revealed 180 up-regulated and 202  down-regulated miRNAs. Among them, 4 up-regulated and 8 down-regulated miRNAs were  associated with progression of hormonal resistance of breast tumors. The bioinformatical  analysis of 4 up-regulated exosomal miRNAs revealed 2 miRNAs, mir- 101and mir-181b, which up-regulated PI3K signaling  supporting the key role of PI3K/Akt in the development of the resistant phenotype of breast cancer cells.
Budget deficits, investment and economic growth: a panel cointegration approach
Authors: Abel Molocwa Goitsemodimo , Khamfula Yohane , Cheteni Priviledge
Published: September 2018

This paper discusses the political economy of budget deficits among the BRICS nations between 1997 and 2016 using a panel cointegration approach to determine the long-run relationship between economic growth, budget deficits, inflation and gross investment. The results of the study show a long-run equilibrium association among economic growth and the selected variables. Furthermore, there is a positive relationship between budget deficit, inflation, and economic growth, for the period under study for BRICS countries. Lastly, the results support the view that there is bi-directional linkage from budget deficit to economic growth and vice versa.
Effect of Paclitaxel-Loaded PLGA Nanoparticles on MDA-MB Type Cell Lines: Apoptosis and Cytotoxicity Studies
Authors: Vijayan Venugopal , Shalini Krishnan , Yugesvaran V. , Yee Teh Hui , Balakrishnan Siventhiran , Palanimuthu Vasanth Raj
Published: September 2018

Background:

Triple-Negative Breast Cancer is an aggressive type of breast cancer, which is not treatable
by chemotherapy drugs, due to the lack of Estrogen Receptor (ER), Progesterone Receptor (PR) expression
and Human Epidermal Growth Factor Receptor 2 (HER2) on the cell surface.

Objective:

The aim of this study was to compare the effect of paclitaxel loaded PLGA nanoparticle (PTX-NPs) on
the cytotoxicity and apoptosis of the different MDA-MB type of cell lines.

Method:

PTX-NPs were prepared by nanoprecipitation method and characterized earlier. The cytotoxicity of
PTX-NPs was evaluated by MTT and LDH assay, later apoptosis was calculated by flow cytometry analysis.

Results:

The prepared NP size of 317.5 nm and zetapontial of -12.7 mV showed drug release of 89.1 % at 48 h.
MDA-MB-231 type cell showed significant cytotoxicity by MTT method of 47.4 ± 1.2 % at 24 h, 34.6 ± 0.8 % at
48 h and 23.5 ± 0.5 % at 72 h and LDH method of 35.9 ± 1.5 % at 24 h, 25.4 ± 0.6 % at 48 h and 19.8 ± 2.2 % at
72 h with apoptosis of 47.3 ± 0.4 %.

Conclusion:

We have found that PTX-NPs showed the cytotoxic effect on all the MDA-MB cancer cell lines and
showed potent anticancer activities against MDA-MB-231 cell line via induction of apoptosis.
Does HbA1cc Play a Role in the Development of Cardiovascular Diseases?
Authors: Prasad Kailash
Published: September 2018

Cardiovascular diseases (CVD) may be mediated through increases in the cardiovascular risk factors.
Hemoglobin A1c (HbA1c) also called glycated hemoglobin is presently used for the diagnosis and management
of diabetes. It has adverse effects on cardiovascular system. This review deals with its synthesis and effects on the
cardiovascular system. The serum levels of HbA1c have been reported to be affected by various factors including,
the lifespan of erythrocytes, factors affecting erythropoiesis, agents interfering glycation of Hb, destruction of
erythrocytes, drugs that shift the formation of Hb, statins, and drugs interfering the HbA1c assay. Levels of
HbA1c are positively correlated with serum glucose and advanced glycation end products ( AGE), but no correlation
between AGE and serum glucose. AGE cannot replace HbA1c for the diagnosis and management of diabetes
because there is no correlation of AGE with serum glucose, and because the half-life of protein with which glucose
combines is only 14-20 days as compared to erythrocytes which have a half-life of 90-120 days. HbA1c is
positively associated with CVD such as the carotid and coronary artery atherosclerosis, ischemic heart disease,
ischemic stroke and hypertension.HbA1c induces dyslipidemia, hyperhomocysteinemia, and hypertension, and
increases C-reactive protein, oxidative stress and blood viscosity that would contribute to the development of
cardiovascular diseases. In conclusion, HbA1c serves as a useful marker for the diagnosis and management of
diabetes. AGE cannot replace HbA1c in the diagnosis and management of diabetes. There is an association of
HbA1c with CVD which be mediated through modulation of CVD risk factors.
Computer-aided Drug Design and Drug Pharmacokinetic Prediction: A Mini-review
Authors: Tabeshpour Jamshid , Sahebkar Amirhossein , Zirak Mohammad Reza , Zeinali Majid , Hashemzaei Mahmoud , Rakhshani Sajed , Rakhshani Saleh
Published: September 2018

Prediction of pharmacokinetics and drug targeting is a challenge in drug design. There are different
types of software that can help to predict the pharmacokinetic profile of a drug. Quantitative structure-activity
relationship (QSAR) modeling is used for drug design with less cost. Drug-excipient interactions are predicted by
docking tools. Computerized drug target prediction and docking programs offer additional options to predict
potential effects and adverse reactions of a given candidate as well as the best orientation of the compound on the
receptor active site. Information on the absorption, distribution, metabolism and excretion of the drug in the body
can enhance prediction of drug release and distribution in the blood and central nervous system (CNS). Computer-
aided drug design and delivery can help to save the time and cost in the process of rational drug development.
Mitochondria and the Pathophysiological Mechanism of Atrial Fibrillation
Authors: Li Xinye , Yang Xinyu , Li Yanda , Yuan Mengchen , Tian Chao , Yang Yihan , Zhang Xiaoyu , Liu Chao , Gao Yonghong , Liu Nian , Shang Hongcai , Xing Yanwei
Published: September 2018

Atrial fibrillation (AF) is the most common and significant cardiac arrhythmia in clinical practice,
however the pathophysiological mechanism of AF has not been fully explained. At present, there are no available
treatment options that can target the underlying pathophysiological processes of AF. Research on improving
management strategies for AF can start with a further understanding of the changes of cells in AF. Mitochondria
play central roles in the function of cardiac myocytes and many of the pathophysiological processes implicated in
AF are relative to mitochondrial function, including formation of reactive oxygen species (ROS), calcium homeostasis,
and alterations of oxygen consumption. The changes of levels of phosphocreatine, electron transfer chain
proteins and differences in mitochondrial distribution further imply that mitochondria play a role in AF. Related
studies of recent years are summarized, in order to elucidate the causal relationship between mitochondria and
AF, and provide potential therapeutic target for the treatment and prevention of AF in clinical practice. In the
article, we summarize the direct or indirect factors that affect mitochondria function and thus cause AF, including
anticancer agents, surgery, gene, age, air pollution, oxidative stress, and β3-adrenoceptor (β3-AR). There is a
close relationship between mitochondrial dysfunction and the occurrence of AF, which cannot be ignored, and
further research in this area is needed.
Tetrazole 5-Acetic Acid Catalyzed Synthesis and Photophysical Study of 2-Aryl-2,3-dihydroquinolin-4(1H)-ones
Authors: Mondal Mohabul A. , Khan Abdul Ashik , Mitra Kanchan
Published: September 2018

1H-Tetrazole 5-acetic acid (TAA) has been explored as a new organocatalyst for the synthesis
of 2-aryl-2,3-dihydroquinolin-4(1H)-ones derivatives from 2’-aminoacetophenone under solventfree
conditions. The method described herein is covenient and the catalyst could be reused. Mechanistic
study of the reaction revealed that the reaction passing through initial activation of the aldehyde by
the catalyst and the C-C bond formed through the intermolecular pathway. The synthesized compounds
exhibit yellowish-white fluorescence when exposed to 350 nm UV light. Optical properties such as absorption
and fluorescence emission spectra were monitored in methanol. Fluorescence emission properties
in different solvents with different polarity indicate solvatochromic characteristics of the probes.
Design, Synthesis, In vitro Cytotoxic Activity Evaluation, and Study of Apoptosis Inducing Effect of New Styrylimidazo[1,2-a]Pyridines as Potent Anti-Breast Cancer Agents
Authors: Khalili Faeze , Akrami Sara , Safavi Malihe , Mohammadi-Khanaposhtani Maryam , Saeedi Mina , Ardestani Sussan K. , Larijani Bagher , Zonouzi Afsaneh , Tehrani Maliheh B. , Mahdavi Mohammad
Published: September 2018

Background:

This paper reports synthesis, cytotoxic activity, and apoptosis inducing effect of a novel
series of styrylimidazo[1,2-a]pyridine derivatives.

Objective:

In this study, anti-cancer activity of novel styrylimidazo[1,2-a]pyridines was evaluated.

Methods:

Styrylimidazo[1,2-a]pyridine derivatives 4a-o were synthesized through a one-pot three-component reaction
of 2-aminopyridines, cinnamaldehydes, and isocyanides in high yield. All synthesized compounds 4a-o were
evaluated against breast cancer cell lines including MDA-MB-231, MCF-7, and T-47D using MTT assay. Apoptosis
was evaluated by acridine orange/ethidium bromide staining, cell cycle analysis, and TUNEL assay as the mechanism
of cell death.

Results:

Most of the synthesized compounds exhibited more potent cytotoxicity than standard drug, etoposide.
Induction of apoptosis by the most cytotoxic compounds 4f, 4g, 4j, 4n, and 4m was confirmed through mentioned
methods.

Conclusion:

In conclusion, these results confirmed the potency of styrylimidazo[1,2-a]pyridines for further drug
discovery developments in the field of anti-cancer agents.
Mild Cognitive Impairment and its Diagnosis to Progression to Dementia with Several Screening Measures
Authors: Sinha Avanika , Sinha Ambalika
Published: September 2018

Background:

Mild Cognitive Impairment (MCI) is the stage of an individual’s life in which there can be traced a slight amount of decline in cognitive functioning that comprised of memory and thinking skills. This decay in cognitive functioning does not affect the daily functioning of a patient’s life as it happens in the case of dementia.

Objective:

To review various forms of screening test measures to assess mild cognitive impairment and its extension towards the gradual onset towards the severe cognitive dysfunctioning such as dementia.

Method:

There are certain functional impairments that are identical to each other. As far as memory and thinking abilities are concerned, its range may vary from minimal to mild that remains quite unnoticed by the person.

Results:

Presently, the impact of medication is not so effective for MCI. Regular practices of exercises, mind activity and social involvement may help in decreasing risk of further cognitive function decline. Patients with MCI may carry greater risks of developing dementia as compared to the general population. The present paper discusses various intervention techniques and screening measures to mitigate the prevalence of MCI and to reduce progression of dementia.

Conclusion:

Prevalence of Mild Cognitive Impairment could be reduced with the primary administration of intervention strategies and technology in order to reduce its progression to dementia. The classification and categorization of MCI in getting broader and clear day by day. The expansion in the use of imaging techniques and other neurological intervention strategies may further enhance the detection of subjects with MCI.
Az agrár-élelmiszer gazdaság üzleti kapcsolataiban szereplő információs és kommunikációs technológiák (IKT) alkalmazásának vizsgálata
Authors: Boros-Papp Sándor , Várallyai László
Published: September 2018

A kis- és középvállalkozások Európa gazdaságának a motorjai. Ezt bizonyítja a 2000-ben elfogadott Európai Kisvállalati Charta is, valamint az, hogy a szektor több mint 90 millió embert foglalkoztat. Hatékony működésükhöz, versenyképességük megtartásához megfelelő információs és kommunikációs technológia ellátottság elengedhetetlen. Termelékenységük akadálytalan növekedése szempontjából ezen technológiákat tudniuk kell megfelelően alkalmazniuk. Tanulmányunk célja a magyar KKV szektor regionális IKT ellátottságának felmérése és összehasonlítása az EU tagállamokkal.
REFORMA PSIQUIÁTRICA VERSUS SISTEMA DE JUSTIÇA CRIMINAL: A LUTA PELA EFETIVIDADE DOS DIREITOS HUMANOS AO LOUCO INFRATOR
Authors: De Deus Pereira Sarah Caroline
Published: September 2018

Cuida-se de analisar as implicações da Lei n. 10.216/01, alcunhada por Lei da Reforma Psiquiátrica, no que se refere ao tratamento despendido ao louco infrator. Por conseguinte, evidenciar a problemática da aplicabilidade da política de saúde mental face ao pranteado modelo jurídico-terapêutico-punitivo-prisional dos Hospitais de Custódia e Tratamento Penitenciários (HCTPs). Neste raciocínio, se mostra evidente o conflito aos direitos humanos em face ao diploma legal em comento, por não se coadunarem com o sistema de justiça criminal brasileiro, sendo este ineficaz no tratamento do portador de transtorno mental que comete crime, em especial nos casos de psicopatia.Palavras-chave: Lei da Reforma Psiquiátrica; louco infrator; direitos humanos; justiça criminal; Direito Penal.AbstractTake care to analyze the implications of the Law 10.216/01,  nicknamed by the Psychiatric Reform Law, as  when handling the insane offender spent. By  therefore highlight the issue of applicability  of mental health policy in the face of model mourned  Therapeutic legal punishment of prison-hospitals  Custody and Correctional Treatment (HCTPs). In this  reasoning, the conflict appears evident rights  human face to the statute in comment, for not  commensurate with the Brazilian criminal justice system,  which is ineffective in the treatment of patients with  mental disorder who commits a crime, especially in cases  of psychopathy.Keywords: Psychiatric Reform Act; insane offenders, human rights, criminal justice, criminal law.
LEIBNIZ – IDENTITÄT UND INDIVIDUALITÄT IM DENKEN F. W. J. SCHELLINGS
Authors: Asmuth Christoph
Published: September 2018

Die Interpretation der Leibnizschen Monadenlehre ist bei Schelling transformiert in den eigenen Entwurf einer Identitätstheorie. Dies scheint ein der Philosophie selbst eingeschriebenes Verfahren zu sein: Theoriestücke vergangener Positionen werden zu Bausteinen neuerlicher Theoriebildungen, werden verwandelt und erlangen in verwandelter Gestalt neue Bedeutung. Zu denken geben muss nur die Tatsache, dass dieser Transformation des Vergangenen oft nur eine unzureichende, bisweilen einseitige, oft kurzsichtige, in jedem Fall aber eine ahistorische Interpretation zugrunde liegt. So interpretiert Schelling in der Tat die Monadenlehre, aber er interpretiert sie von vornherein im Bezugsrahmen der nachkantischen Transzendentalphilosophie: im Horizont der Frage nach dem Ding an sich, der Frage nach der Realität der Außenwelt, der Frage nach der Bewusstseinsimmanenz alles Seienden. Dadurch erscheint die Konzeption von Leibniz insgesamt verkürzt: Die Funktion Gottes als Schöpfer, als Garant einer prästabilierten Harmonie und Stabilisator der Vernunftwahrheiten, als ursprüngliche einfache Substanz (Abschnitt 47) muss in der Transzendentalphilosophie Schellingscher Ausprägung gestrichen werden. Für sie ist kein Ort mehr vorgesehen. An ihre Stelle rückt eine Subjekt-Objekt-Konzeption, in der die Individualität zwar abstrakt eingelassen ist, deren Basis aber eine Theorie der Selbstverursächlichung bildet, neben der und außerhalb ihrer ein philosophischer Gott nicht bestehen kann. Außerdem fehlen bei Schelling – das sei hier nur grob angedeutet – wesentliche Aspekte: etwa die politischen, sozialen und ethischen.
POSSIBLE WORLDS IN THE PRECIPICE: WHY LEIBNIZ MET SPINOZA?
Authors: Vidinsky Vassil
Published: September 2018

The main objective of the paper is to give initial answers to three important questions. Why did Leibniz visit Spinoza? Why did his preparation for this meeting include a modification of the ontological proof of God? What is the philosophical result of the meeting and what do possible worlds have to do with it? In order to provide answers, three closely related manuscripts by Leibniz from November 1676 have been compared and the slow conceptual change of his philosophical apparatus has been analyzed. The last of these manuscripts was presented and read in front of Spinoza. Around that time Leibniz abandoned the idea of plurality of worlds (cf. Tschirnhaus) and instead proposed the idea of possible worlds, thus introducing possibility into the (onto/theo)logical structure itself in order to avoid the “precipice” of Spinoza’s necessity. What is interesting, however, is how exactly this conceptual change occurred at the end of 1676 and what its philosophical and methodological implications are.
THE RELATIONSHIP BETWEEN PERSONAL AND PROFESSIONAL CHARACTERISTICS OF TEACHERS
Authors: Đigić Gordana
Published: September 2018

Numerous research projects show that teachers’ professional behavior is one of the key factors in the effectiveness of teaching and students’ educational achievements. Also, modern trends in education put more and more complex demands on teachers. Therefore, it is important to understand the factors that contribute to the success of teachers’ work with students. In the study presented in this paper, conducted on a sample of 148 teachers from elementary and secondary schools in Serbia, the relationship between teachers’ personal and professional characteristics was examined, i.e. the possibility of predicting teachers’ classroom management styles and self-efficacy by the measures of personality dimensions from the Big Five model, empathy and locus of control was investigated. As important predictors of teachers’ classroom management styles, some personality dimensions were highlighted (Openness, Agreeableness and Conscientiousness as important predictors of the Interactionist style, with the greatest particular contribution of the Openness dimension), as well as the locus of control (the external locus of control predicting a more pronounced Intervening and Non-intervening style). Lower Empathic Concern has a significant particular contribution to the prediction of the Noninterventionist style as well. Important predictors of teachers’ self-efficacy are mostly some personality traits (the most often higher Extraversion and lower Neuroticism) and empathy dimensions (mostly Perspective Taking and Personal distress). It could be concluded that all investigated teachers’ personal characteristics provide a significant contribution to their important professional features. The obtained results could be useful in creating ways to support teachers’ professional development.
ONLINE MEDIA AS CONFLICT GENERATORS
Authors: Stamenković Ivana , Nikolić Miljana , Aleksić Dušan
Published: September 2018

The media have always had great influence on the construction of attitudes and opinions of the public, thus it comes as no surprise that they constantly adjust to contemporary tides and the ways in which the public obtains information. Thanks to the popularity and possibilities offered by the Internet, the media were forced to converge towards online forms of reporting. Besides this, the Internet enabled the removal of state limits when it comes to informing, so the public can learn more easily about events from all over the world. In this way, mass-media communication gets new outlines while directing social tides on the global level. Although such a trend can be useful, it can also carry certain dangers. Therefore, the new media can become a platform for international conflicts and lead to possible interruption of good relations among states. Considering the fact that relations between Serbia and Croatia are characterised by a now concluded war, this paper examines the way in which the Serbian and the Croatian online media report on the relationship between the two states from the perspective of political relations, media presentations of each other, as well as how large the role of the modern media is in provoking new conflicts. Using a quantitative-qualitative analysis of the content, both the Serbian and the Croatian versions of the portal “24 hours” were analysed within the period from April 1  to April 30, 2017.
Del 68 a hoy: la movilización política de las mujeresDel 68 a hoy: la movilización política de las mujeres
Authors: Lamas Marta
Published: September 2018

¿Qué es la memoria política sino la continuidad de las insistencias, las reiteraciones, las certezas fulgurantes de logro o derrota, el amor a las vivencias que al evocarse suscitan ideas de nobleza propia y monstruosidad ajena?

Carlos Monsiváis

Este artículo indaga las coincidencias y diferencias entre la movilización de las mujeres en el movimiento estudiantil de 68 y la de las jóvenes activistas feministas de hoy. Para ello revisa los primeros textos sobre el movimiento estudiantil, en especial los escritos por los líderes, donde encuentra una ausencia de reflexiones sobre la participación de las mujeres. También recupera el trabajo de dos autoras que, inquietas por esa ausencia, investigaron las intervenciones de las mujeres, y registraron una variedad de acciones, incluso con actitudes feministas poco conocidas. Además, da cuenta del giro que algunos autores dieron posteriormente, al reconocer el papel de las mujeres. Por último, establece cierta correlación entre las preocupaciones que impulsan la actual forma de movilización de las jóvenes feministas en un contexto de múltiples violencias y la de las activistas del 68.
1968 en la memoria de América Latina y el mundo
Authors: Santana Adalberto
Published: September 2018

Una parte de la generación de estudiantes que hicieron el movimiento de 68, una pequeña parte, no más de 7 u 8 millares en medio millón de estudiantes de enseñanza media y superior, se había construido en un caldo de cultivo político-cultural que tenía la virtud de la globalidad. Esa locura integral nos rodeaba por todas las esquinas de la vida. Tenía que ver con las lecturas, los héroes, los mitos, las renuncias, el cine, el teatro, el amor, la información. Vivíamos rodeados de la magia de la revolución cubana y la resistencia vietnamita.

Paco Ignacio Taibo II (1998: 16)

En el trabajo se presenta un recuento de las situaciones y coyunturas políticas que durante el año trascendental de 1968 se manifestaron en el mundo y de manera particular en la región de América Latina y el Caribe. Se exponen las expresiones políticas que estuvieron interconectadas en torno a las protestas estudiantiles y juveniles que se dieron en aquellos momentos. De la misma manera, a cincuenta años de los sucesos, se destaca la relativa importancia y trascendencia del 68 que ha llegado hasta nuestros días.
Los 68: movimientos estudiantiles y sociales en un emergente transnacionalismo y sus olas dentro del sistema-mundo. A manera de editorial
Authors: Bokser Misses-Liwerant Judit , Saracho López Con Federico José
Published: September 2018

El presente artículo estudia los movimientos de 1968 alrededor del mundo como muestra de incipientes procesos de globalización y un nuevo transnacionalismo en cuyos márgenes cambiantes los nuevos actores concatenaron agencia social y circuitos culturales para trascender las fronteras nacionales. A través del análisis de algunos de los casos más representativos, se estudia el hilvanado transnacional que se dio en 1968, a partir de la movilización estudiantil y los movimientos sociales que cuestionaron los regímenes políticos de diverso signo, así como su escasa capacidad de respuesta –cuando no represión– a las demandas por derechos civiles, por reformas democráticas y por el fin de la guerra. El examen de las convergencias y divergencias a nivel global, así como sus contradicciones no desatiende el análisis de los casos específicos. Junto al encuadre analítico, el artículo refiere, a su vez, a manera de editorial, a las colaboraciones que conforman este número especial de la Revista. El texto abre así un rico debate sobre 1968 como año fundacional.

 
Presentación
Authors: Cuéllar Vázquez Angélica
Published: September 2018

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Química en microescala en los laboratorios de Química Inorgánica y Organometálica
Authors: Amaíz Francisco J.
Published: September 2018

Aparentemente la química en microescala no representa nada nuevo. Cuando los de mi generación echamos una mirada retrospectiva a nuestra época de estudiantes, allá por la década de 1960, recordamos que, por ejemplo, en los laboratorios de Química General la determinación de puntos de fusión se hacía con muestras de unos pocos miligramos en un capilar adosado a un termómetro que se introducía en el tubo de Thiele; en los laboratorios de Química Analítica el reconocimiento de aniones y cationes se realizaba frecuentemente a través de ensayos a la gota y la determinación complejométrica de metales con AEDT...
Pertumbuhan dan Tingkat Morbiditas pada Bayi Usia 7-12 Bulan berdasarkan Status Pemberian ASI di Wilayah Puskesmas Gilingan Kecamatan Banjarsari Surakarta
Authors: Nurhayati Indah , Widyaningsih Endang Nur , Subagyo Agus
Published: September 2018

ASI selain dapat membantu dalam proses pertumbuhan, juga dapat melindungi bayi dari berbagai penyakit infeksi seperti diare dan ISPA. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh status pemberian ASI terhadap pertumbuhan dan tingkat morbiditas pada bayi usia 7-12 bulan di Wilayah Puskesmas Gilingan. Penelitian ini menggunakan rancangan studi kohort retrospektif, yang dilakukan di posyandu wilayah Puskesmas Gilingan. Total sampel pada penelitian ini sebanyak 58 responden, pengambilan sampel menggunakan Consecutive Sampling. Instrumen penelitian berupa kuesioner ASI eksklusif, tingkat morbiditas dan KMS. Teknik analisis uji adalah Chi Square. Hasil penelitian ini adalah tidak ada pengaruh status pemberian ASI terhadap pertumbuhan bayi usia 7-12 bulan dengan p = 0,378 nilai RR 1,667 (IK 95% = 0,697-3,984). Tidak terdapat pengaruh status pemberian ASI terhadap kejadian ISPA pada bayi usia 7-12 bulan dengan p = 0,066 nilai RR 1,800 (IK 95% = 1,011–3,204). Tidak ada pengaruh status pemberian ASI terhadap kejadian diare pada bayi usia 7-12 bulan dengan p = 0,564 nilai RR 1,158 (IK 95% = 0,829–1,618).
DIMENSI KEARIFAN LOKAL MASYARAKAT LAMPUNG SEBAGAI MEDIA RESOLUSI KONFLIK
Authors: Ruslan Idrus
Published: September 2018

Di tengah munculnya konflik dan dibalik fenomena kompleksitas serta kekacauan yang terjadi pada masyarakat saat ini, apalagi daerah tersebut merupakan daerah yang multi agama dan etnis seperti di Lampung.  Diperlukan kontribusi berbagai macam cara untuk dijadikan acuan bagi individu dan kelompok masyarakat dalam berinteraksi diantara mereka guna mewujudkan tatanan yang berkualitas. Salah satu cara yang potensial bagi persoalan tersebut adalah kearifan lokal. Kearifan lokal masyarakat Lampung yang diketengahkan disini yaitu Piil Pesenggiri dan Muakhi yang keduanya secara ideal memiliki nilai dan spirit universal sehingga bisa dijadikan rujukan bagi masyarakat Lampung.   Kearifan lokal dimaksud seharusnya teraktualisasi bukan hanya bagi masyarakat yang beretnis Lampung, akan tetapi juga bagi masyarakat pendatang (datang dari daerah lain/suku lain) agar supaya dapat saling menghargai, menghormati dan memahami adanya perbedaan tradisi.  Hal ini diperlukan dalam rangka mengantisipasi kesalahpahaman yang tidak jarang berujung pada konflik hingga pada akhirnya dapat merugikan masyarakat itu sendiri.