bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 10 from Oncogenic KRAS Mutations Confer a Unique Mechanotransduction Response to Peristalsis in Colorectal Cancer Cells
Authors: Clevenger Abigail J. , Collier Claudia A. , Gorley John Paul M. , Colijn Sarah , McFarlin Maygan K. , Solberg Spencer C. , Kopetz Scott , Stratman Amber N. , Raghavan Shreya A.
Published: February 2025

Supplementary Figure 10 demonstrates LGR5 cancer stem cell enrichment in HCT116 cells exposed to static, shear, strain and peristalsis forces.
Supplementary Table S1 from TIPE Inhibits Ferroptosis in Colorectal Cancer Cells by Regulating MGST1/ALOX5
Authors: Yan Changxiu , Yu Shengnan , Zhang Jing , Li Zhen , Lin Zeyang , Zhang Shiying , Li Haoyang , Ye Zhijian , Huang Jiyi , Ye Yuhan , Zhuang Guohong
Published: February 2025

The key cell culture reagents used for cell viability detection assays in this study.
Supplemental Table 6 from ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity
Authors: Hebron Katie E. , Perkins Olivia L. , Kim Angela , Jian Xiaoying , Girald-Berlingeri Sofia A. , Lei Haiyan , Shern Jack F. , Conner Elizabeth A. , Randazzo Paul A. , Yohe Marielle E.
Published: February 2025

Source Data
Supplemental Table 5 from ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity
Authors: Hebron Katie E. , Perkins Olivia L. , Kim Angela , Jian Xiaoying , Girald-Berlingeri Sofia A. , Lei Haiyan , Shern Jack F. , Conner Elizabeth A. , Randazzo Paul A. , Yohe Marielle E.
Published: February 2025

Differentially expressed gene list siASAP1 v control trametinib
Supplementary Table 5 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

GBM1 H3K4me3 GSEA gene sets containing target genes
Supplemental Table 3 from ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity
Authors: Hebron Katie E. , Perkins Olivia L. , Kim Angela , Jian Xiaoying , Girald-Berlingeri Sofia A. , Lei Haiyan , Shern Jack F. , Conner Elizabeth A. , Randazzo Paul A. , Yohe Marielle E.
Published: February 2025

Taqman Probes
Supplementary Table 4 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

BT245 H3K27me3 GSEA gene sets containing target genes
Supplemental Figure 5 from ASAP1 and ARF1 Regulate Myogenic Differentiation in Rhabdomyosarcoma by Modulating TAZ Activity
Authors: Hebron Katie E. , Perkins Olivia L. , Kim Angela , Jian Xiaoying , Girald-Berlingeri Sofia A. , Lei Haiyan , Shern Jack F. , Conner Elizabeth A. , Randazzo Paul A. , Yohe Marielle E.
Published: February 2025

Knockdown verification and additional analysis for Figure 3
Supplementary Figure 9 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

Figure S9. Metascape analysis of differential gene expression effects in GBM1 cells.
Supplementary Figure 8 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

Figure S8. Metascape analysis of differential gene expression effects in BT245 cells.
Supplementary Figure 7 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

Figure S7. Summary of genes and pathways at which H3K4me3 or H3K27me3 were differentially expressed in PRMT5 KD versus control cells.
Supplementary Figure 6 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

Figure S6. Differential effects of PRMT5 KD on H3K27me3, H3K4me3 and H3K27ac occupancy in BT245 and GBM1 cells.
Supplementary Figure 1 from PRMT5 Maintains Tumor Stem Cells to Promote Pediatric High-Grade Glioma Tumorigenesis
Authors: DeSisto John , Balakrishnan Ilango , Knox Aaron J. , Link Gabrielle , Venkataraman Sujatha , Vibhakar Rajeev , Green Adam L.
Published: February 2025

Figure S1. a. tumor phylogeny for CNS/Brain category used in the Broad Institute DepMap project, OncoTree (oncotree.info) Kundra et al., JCO Clinical Cancer Informatics 2021; b. individual sample distribution for the shaded curves shown in Figure 1e.
Batryticatus bombyx improved atopic dermatitis in NC/Nga mice and impact on inflammation and recovery of skin barrier via STAT1/P38/NF-κB downregulation and HO-1/Nrf2 activation in HaCaT keratinocytes
Authors: Park Gunhyuk , Jang Yumi , Moon Byeong Cheol , Lim Hye-Sun
Published: February 2025

Introduction: Batryticatus bombyx (BB) (Beauveria bassiana Vuill.) is used as an herbal medicine and food additive. Although BB has neuroprotective and anti-apoptotic effects, its impacts on atopic dermatitis (AD) are unknown. We evaluated the effects of BB in an NC/Nga mouse model of house dust mite (HDM)-induced AD, in TNF-α and IFN-γ (TI)-stimulated HaCaT keratinocytes, and in a 3D human skin model. Methods: NC/Nga mice were induced with HDM and treated with BB for 6 weeks. We assessed skin symptoms, serum levels of IgE, histamine, and IL-6, immune cell counts, and performed histological analysis of dorsal skin tissue. Additionally, we induced inflammation in HaCaT cells and a 3D human skin model using TNF-α/IFN-γ. We measured inflammatory cytokine levels, skin hydration factors, and delved into underlying mechanisms via ELISA, real-time PCR, and Western blot. Results: BB improved skin lesions, reduced thickness, and inflammatory cell infiltration in HDM-induced mice. It alleviated scratching, improved moisture retention, and reduced IgE, histamine, and IL-6 levels. In HaCaT cells, BB inhibited thymic stromal lymphopoietin and increased hyaluronan content. It also upregulated aquaporin-3, hyaluronan synthase-1/3, filaggrin, involucrin, and occludin, enhancing skin hydration and tight junction stability. BB decreased STAT1, p38 MAPK, and NF-κB p65 levels in HaCaT cells and exhibited antioxidant effects by increasing HO-1/Nrf2 expression. Conclusion: BB may serve as a therapeutic alternative for AD treatment by inhibiting skin inflammation.
Unaware processing of words activates experience-derived information in conceptual-semantic brain networks
Authors: Ghio Marta , Cassone Barbara , Tettamanti Marco
Published: February 2025

The recognition of manipulable objects results from the encoding of sensory input in combination with predictive decoding of experience-derived visuomotor information stored in conceptual-semantic representations. This grounded interpretative processing was previously found to subsist even under unaware perception of manipulable object pictures. In this fMRI study, we first aimed to extend this finding by testing whether experientially grounded visuomotor representations are unawarely recruited when manipulable objects are not visually depicted, but only referred to by words presented subliminally through continuous flash suppression. Second, we assessed the generalizability of decoding experience-derived conceptual information to other semantic categories, by extending our investigation to subliminally presented emotion words and testing for unaware recruitment of grounded emotion representations in the limbic system. Univariate analysis of data sampled from 21 human participants (14 females) showed that manipulable object words selectively activated a left-lateralized visuomotor network, both when words were presented below perceptual threshold and when participants subjectively reported lack of stimulus awareness. Emotion words selectively engaged the bilateral limbic network, although univariate analysis did not provide evidence for its recruitment under subliminal perceptual conditions. In turn, multivariate pattern analysis showed that neural codes associated with both manipulable object and emotion words could be decoded even in the absence of perceptual awareness. These findings suggest that the brain automatically engages in conceptual-semantic decoding of experience-derived information not only when circumstances require to interact with manipulable objects and emotions, but also when these referents are dislocated in time and space and only referred to by words.
Magnitude processing and integration entail perceptual processes independent from the task
Authors: Togoli Irene , Collignon Olivier , Bueti Domenica , Fornaciai Michele
Published: February 2025

The magnitude dimensions of visual stimuli, such as their numerosity, duration, and size, are intrinsically linked, leading to mutual interactions across them. However, it remains debated whether such interactions, or “magnitude integration” effects, arise from perceptual processes that are independent from the task performed, or whether they arise from high-level decision-making processes. We address this question with two electroencephalography (EEG) experiments in which participants watched a series of dot-array stimuli modulated in numerosity, duration, and item size, in two separate conditions. In the “magnitude task” condition, participants judged either the numerosity, duration, or size of each stimulus. In the “contrast task” condition, instead, a separate group of participants performed a contrast oddball task, never attending or judging the magnitude of the stimuli. The results of the magnitude task first show robust integration effects across the three dimensions. Then, we compare the neural responses to magnitude across the two task conditions. This comparison shows very similar brain responses irrespective of the task, within a series of latency windows whereby the modulation of response amplitude can predict the behavioral magnitude integration effect (~150 and ~250 ms post-onset for numerosity and size; ~300 ms post-offset for the effect of duration). To better assess the similarity of brain responses to magnitude irrespective of the task, we use a cross-condition multivariate decoding analysis. This analysis demonstrates that brain responses in the magnitude task can predict the responses in the contrast task, at multiple latencies starting from early processing stages (~120 ms). These results suggest that magnitude processing and integration likely involve perceptual processes that are engaged irrespective of the task, thus independently from decision making, although the effect of duration on other magnitudes may also involve post-perceptual processes such as working memory.
New Words to Old Tunes
Authors: Haydar Adnan
Published: February 2025

New Words to Old Tunes: Genres and Metrics of Lebanese Zajal Poetry introduces the rich tradition of Lebanese oral poetry, offering an in-depth study and analysis of its metrics and genres. It presents a novel framework for the proper scansion of meters and emphasises the previously overlooked roles of musical and poetic stress. It details nearly twenty zajal genres, including popular songs that use zajal metrics, and integrates musical notations and web-streamed audio links to enrich the reader’s experience.

By presenting both theoretical analysis and practical applications, the book not only contributes to the academic study of Lebanese and Arab oral traditions but also supports broader efforts to preserve and disseminate this cultural heritage through digital humanities. While previous works have been largely descriptive or focused on specific poets, this book provides a detailed analytical approach to zajal metrics and their musical dimensions.

This rigorous and comprehensive study will be of interest to scholars working on oral traditions, folklore studies, ethnomusicology, cultural studies, oral-formulaic poetry traditions, throughout the Middle East and beyond.
5. Qarrādī and Its Various Manifestations
Authors: Haydar Adnan
Published: February 2025

The fifth chapter provides a thorough discussion of Qarrādī, starting with Maronite hymns (Afrāmiyyāt) and folk poetry, caddiyyāt (counting rhymes), hymns, and other examples. Included are musical transcriptions of popular Lebanese songs in the qarrādī style. An in-depth analysis of Khuzām (Lebanese Muwashshaha style) is undertaken, including an example in Lebanese dialect and French, reminiscent of Hispano-Arabic prototypes.
6. ʿAtābā, Mījanā, and Other Popular Genres
Authors: Haydar Adnan
Published: February 2025

The sixth chapter lays out a thorough discussion of the musical transcription and scansion of cAtāba and Mījana – the two most popular genres – and several other popular genres, including the short, middle and long Qaṣīd, al-Ḥida, al-Nadb (funeral tunes), al-Ḥawrabah, al-Zalghaṭa, Abu al-Zuluf, al-Shurūqi, al-Mawwāl al-Baghdādī, al-Mukhammas al-Mardūd, etc. Also included in the discussion is the incorporation of oral-formulaic strategies by poets and an emphasis on the importance of musical meter to the composition of these genres and the effects of musical stress on poetic and natural linguistic stress patterns.
The 1000-Year Context of Extreme Precipitation in the Central United States from a Novel Blend of Observations and Climate Model Simulations
Authors: Thompson Alexander J. , Hutchings Jack A. , Konecky Bronwen L.
Published: February 2025

Global warming is increasing the frequency of extreme precipitation events, including those referred to as having a return period of 1000 years. Yet frequency estimates of these high-end extremes are plagued by large uncertainties that result from the short record of weather station observations used to assess their historical context. To more robustly assess modern extreme precipitation events, we develop a novel approach that lengthens the data record by blending historical observations from NOAA’s Applied Climate Information System with Community Earth System Model simulations run from 850 to 2100 CE. We apply this method as a proof of concept to the record-breaking rainfall event in the central United States in July 2022. We find that the return period for this storm’s 24-h rainfall is ∼530 years (90% confidence interval: 370–700 years) for the greater St. Louis region and ∼280 years (90% confidence interval: 115–340 years) for eastern Kentucky. Moreover, the rainfall amount from this event is ∼2–4 times more likely to occur in the future relative to the preindustrial era. Compared to previous best practices, this study’s approach more precisely evaluates extreme precipitation magnitude and frequency, demonstrating potentially large reductions in the uncertainty associated with classifying a 1-in-1000-yr rainfall event. This blended data approach can be used to update previous methods used for assessing modern extreme precipitation events and to better prepare society and critical infrastructure for the present and future risks posed by precipitation extremes.

Significance Statement

We present a new method aimed at improving estimates of the magnitude and frequency of extreme precipitation. Our method lengthens the time coverage of precipitation data by combining weather station observations with climate model simulations spanning 850–2100 CE. We apply this methodology to a record-breaking rainfall event that occurred in July 2022 in the central United States. Our approach provides a more precise estimate of this event’s frequency and demonstrates that the rainfall amount from this event is ∼2–4 times more likely to occur in the future relative to the preceding millennium. Our findings can be used to better prepare society and infrastructure for the present and future risks posed by extreme precipitation.
Select Representative General Circulation Model-runs using Enveloped-based Technique
Authors: Mahjour Seyed Kourosh , Tiefenbacher John P. , Faroughi Salah A.
Published: February 2025

A subset of ensemble General Circulation Models (GCMs), known as representative GCMs (RGCMs), is typically used in climate change analysis to reduce computational cost. This study presents a new envelope-based workflow for RGCMs selection beginning with history matching to better preserve the full ensemble uncertainty range and replicate past climate characteristics, in contrast to an envelope-based standard workflow that begins with capturing climatic means. Our workflow contains a three-stage selection process that leverages monthly ground-truth data from the reference period 1981–2005, along with monthly simulation outputs for the periods 1981–2010 and 2071–2100 from GCM-runs in the Coupled Model Intercomparison Project Phase 5 (CMIP5), starting with an initial pool of 105 and 77 runs under Representative Concentration Pathways 4.5 and 8.5, respectively. The performance of the proposed workflow is compared with the standard workflow using the Kolmogorov-Smirnov test measuring Dmax, the largest absolute difference between two cumulative distributions of changes in mean air temperature (ΔT) and precipitation (ΔP) from the full-set of GCM-runs and RGCM-runs, and the mean squared error (MSE) evaluating reproduction of past climate data. The comparisons for Texas show that the new workflow reduces mean Dmax for ΔT by 23% and ΔP by 20%, while improving mean MSE by 105% and 6% for monthly average of mean air temperature and precipitation, respectively. Further evaluation in Bihar, India, and New York State, USA, regions with distinct climatic conditions from those of Texas, consistently shows lower Dmax and MSE for our workflow, indicating that it selects RGCM-runs that better represent the full-set of GCM-runs.
The changing nature of atmospheric rivers
Authors: Henny Lexi , Kim Kyu-Myong
Published: February 2025

Atmospheric rivers (ARs) are expected to strengthen in a warming climate, largely due to the thermodynamic (moistening) effect. Here, we show that this trend is already evident in historical reanalysis data using ARTMIP Tier 2 atmospheric river detection tools (ARDTs) and variants of our own global AR detection applied to ERA5, MERRA-2, and JRA-55 reanalysis data. Over the 1980-2019 (ARTMIP) and 1980-2023 (variants) periods, total AR area increased by 6-9%. AR integrated water vapor (IWV) increased by 2-3% while integrated vapor transport (IVT) increased by less than 1% and 850 hPa wind speed (|V850|) and vertically integrated moisture flux convergence (VIMFC) both decreased. IWV increases were the most robust overall. All trend magnitudes were sensitive to subsetting, with fixed-frequency subsets consisting of most-intense AR grid points showing larger increases of 3-4% IVT, 4-6% IWV, and 5-9% VIMFC, this last opposing a decreasing AR-mean VIMFC trend likely associated with large area increases. For individual ARs, maximum IVT and IWV increased at ~3-6x and ~1.5-2x the rate of AR-mean values, respectively. Regional changes were often even larger, particularly for extreme events, though most geospatial trends had low detectability under a false discovery rate control framework. Ultimately, despite considerable ARDT and methodological diversity, we found robust consensus moistening and expansion of ARs between 1980 and 2023. However, further research is required to determine the extent to which these trends are affected by reanalysis observational assimilation changes. For example, previous studies indicate that certain reanalyses misrepresent 1980-1994 atmospheric moistening and so may underestimate historical AR expansion and intensification rates.
Societal Benefits in Weather, Water, and Climate: Understanding, Communication, and Enhancement
Authors: Higgins Paul
Published: February 2025

Earth system observations, science, and services (OSS) inform and guide the activities of innumerable institutions underlying modern civilization and virtually every social and economic sector. OSS are a foundational component of efforts to meet basic human needs, including having access to food, shelter, energy, and health and safety, among others. This makes OSS a basic building block for virtually all infrastructure nationally and globally. At the same time, the opportunities for societal benefit from OSS are increasing dramatically. This study seeks to 1) characterize broadly the societal benefits of OSS, 2) identify the factors that limit the societal benefits of OSS, 3) develop approaches to enhance those societal benefits, and 4) communicate this information to internal audiences (i.e., the providers of OSS) and external partners (i.e., decision-makers, information users, the media, and the public).
Analyzing the share of media followers of government Twitter accounts across Western European countries
Authors: Reveilhac Maud , Trembovelskyi Bohdan
Published: February 2025

The study investigates which democracy dimensions impact the share of (foreign) media followers of European governments’ Twitter social media accounts. To achieve this target, a network analysis and a data-linking strategy are relied upon to conduct three multilevel regression models. The first model reveals that while overall government media attention is positively associated with gross domestic product and internet penetration, it is negatively associated with higher levels of deliberative democracy. The second model, which focuses specifically on the share of foreign media followers, finds that individual-level factors are the primary predictors of foreign media attention. The third model explores the country context of media followers and indicates that government accounts benefit from followers in countries with higher democratic standards and greater media freedom, though there are negative associations with certain democratic dimensions such as liberal and participative democracy. Additionally, ministers and ministries consistently have a higher proportion of foreign media followers compared to heads of state. These findings are discussed in light of the literature on Twitter's role in media attention and gatekeeping theory.
Thin Flap Trochleoplasty With Medial Patellofemoral Ligament Reconstruction for Recurrent Patellofemoral Instability With High-Grade Trochlear Dysplasia: A Series of 63 Consecutive Cases
Authors: Hiemstra Laurie A. , Rousseau-Saine Alexis , Lafave Mark R. , Kerslake Sarah
Published: February 2025

Background:

Trochlear dysplasia is present in 68% to 85% of patients with recurrent lateral patellofemoral instability (LPI) compared with 3% to 6% of healthy controls. Trochlear dysplasia has been associated with medial patellofemoral ligament (MPFL) graft failure and lower quality-of-life (QOL) outcome scores. The correction of trochlear dysplasia with trochleoplasty is indicated in patients with recurrent LPI and high-grade trochlear dysplasia with a trochlear bump and a significant J-sign.

Purpose:

To assess the clinical and patient-reported outcomes after patella-stabilizing surgery, including thin flap sulcus deepening trochleoplasty, and to explore the influence of pathoanatomic variables on postoperative QOL scores in patients who have undergone patellar stabilization, including trochleoplasty.

Study Design:

Case series; Level of evidence, 4.

Methods:

A total of 63 consecutive knees in 46 patients with recurrent LPI and high-grade trochlear dysplasia who underwent MPFL reconstruction with thin flap trochleoplasty were followed for 2 years postoperatively. Clinical outcomes and Banff Patellofemoral Instability Instrument (BPII) 2.0 scores were collected prospectively. The t test was used to determine changes in QOL. Multiple linear regression was conducted to determine significant pathoanatomic variables that affected outcomes after MPFL reconstruction.

Results:

Overall, 63 knees with a mean follow-up of 32.9 ± 17.0 months (range, 12-84 months) were included. All patients had preoperative high-grade trochlear dysplasia (Dejour type B: 46%; Dejour type D: 54%), with a mean trochlear bump height of 6.1 ± 1.8 mm (range, 3.2-10.5 mm). The BPII 2.0 score increased significantly from preoperatively (29.3 ± 12.4) to postoperatively (71.8 ± 17.4) ( P < .001), with a large effect size (Cohen d = −2.41). There was 1 redislocation (1.6%) and 3 reoperations (4.8%). Persistent apprehension and the J-sign were present in 8.5% and 13.6% of the knees, respectively. Multiple linear regression analysis demonstrated no statistically significant predictive relationship between the 24-month postoperative BPII 2.0 score and the preoperative BPII 2.0 score, tibiofemoral rotation, the Beighton score, or trochlear bump height ( R = 0.47; R2 = 0.22; F = 5.23; P = .13).

Conclusion:

Thin flap trochleoplasty combined with MPFL reconstruction in patients with recurrent LPI and high-grade trochlear dysplasia resulted in low redislocation and reoperation rates at a mean of 33 months. Disease-specific QOL scores were statistically significantly improved from preoperatively to postoperatively.
Order and Potentiality in Interaction Ritual Theory
Authors: Tavory Iddo , Hoynes Nicholas
Published: February 2025

Interaction ritual theory is one of the most important contributions of micro-sociological theory, tying together the production of local order and actors’ ongoing projects. Although Goffman replaced the “social” order of classical anthropology with an endogenous “interaction” order, such theory conceives ritual as reflecting and enacting an existing structure. Drawing on recent interactionist work and developments in ritual theory, we complement this understanding of ritual with an account of potentiality. Interaction rituals undoubtedly sacralize the self that is presented in interaction and defend the interaction order within which such selves are enmeshed, yet they simultaneously open up potential avenues for transformation of selves and relationships. Ritual action is strewn with moments in which the world appears not as it is but as it could be: a subjunctive “what if” of social life. We show how focusing on the interplay between order and potentiality in interaction ritual provides a more precise way to understand interaction and new ways to approach forms of interactional inequality.
Influence of fiber concentration and length on the dielectric, mechanical, and thermal properties of maple wood fiber-reinforced polypropylene
Authors: Basiji Farshid , Erchiqui Fouad , Koubaa Ahmed , Ghasemi Ismaeil
Published: February 2025

Natural fiber-reinforced polymer composites are gaining popularity due to their sustainability and enhanced properties compared to pure polymers. Recently, these composites have been utilized as dielectric materials. In this study, polypropylene (PP) reinforced with maple wood fibers of different lengths (50, 75, and 100 µm) and various fiber concentrations (5%, 10%, 15%, and 20%) were examined. The effects of fiber length and concentration on the dielectric, mechanical, and thermal properties were investigated. All composites exhibited a higher dielectric constant and conductivity than pure PP, along with a lower loss factor. This suggests that adding maple wood fibers generally enhances the dielectric properties. As fiber concentration increases, the dielectric constant tends to rise while the loss factor tends to decrease. TGA results indicated that adding more fibers reduces thermal stability at low temperatures but increases stability at high temperatures. Mechanical testing revealed an increase in strength but a decrease in elongation. However, fiber length did not significantly impact the mechanical properties. SEM analysis showed a uniform distribution of fibers at 5% weight that improves strength, while a 20% weight leads to clustering that weakens the composite.
Significant Publications on Infectious Diseases Pharmacotherapy in 2023
Authors: Stabler Alex V. , Huynh-Phan Ricky , Amin Khyati , Lin Kevin , Patel Shivani , Zaidan Noor , Stramel Stefanie , Thomas Jamie L.
Published: February 2025

Purpose: To provide a summarization of the most significant infectious diseases (ID) pharmacotherapy articles published in peer-reviewed literature in 2023. Summary: Members of the Houston Infectious Diseases Network (HIDN) nominated notable articles providing significant contributions to ID pharmacotherapy in 2023. Article nominations included those pertaining to general ID and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pharmacotherapy. Out of the 31 articles nominated by HIDN members, 22 pertained to general ID pharmacotherapy, and 9 pertained to HIV/AIDS pharmacotherapy. To aid selection of the most notable articles of 2023, a survey was created and distributed to members of the Society of Infectious Diseases Pharmacists (SIDP). Of the 153 SIDP members who participated in the survey, there were 118 recorded votes for the top 10 general ID pharmacotherapy articles and 55 votes were recorded for the top HIV/AIDS article. The most notable publications are summarized. Conclusion: Advances in antimicrobial stewardship and infectious disease states continue to occur. Sustained growth in the publication of ID-related articles over the past year contributed to this review’s aim to aid clinicians in remaining current on potentially practice-changing ID pharmacotherapy publications from 2023. This review provides a summary of recently published ID literature, including emphasis on antimicrobial stewardship, appropriate treatment durations, new antimicrobials, and drug-resistant organisms.
Uncovering potential molecular markers and pathological mechanisms of Parkinson's disease and myocardial infarction based on bioinformatics analysis
Authors: Liu Jian , Xing Lu , Lan Tianye , Wang Qiang , Wang Yitong , Chen Xuenan , Zhao Weimin , Sun Liwei
Published: February 2025

Background

The direct association between Parkinson's disease (PD) and Myocardial infarction (MI) has been the subject of relatively limited research.

Objective

The purpose of this study was to identify the genes most associated with PD and MI to explore their common pathogenesis.

Methods

The gene expression profiles of PD and MI were downloaded from GEO database. Differential expression analysis was performed to identify the common differential expression genes (DEGs) of PD and MI, followed by functional annotation. Subsequently, protein-protein interaction network were constructed, and hub DEGs were identified based on CytoHubba plugin and LASSO regression analysis. To explore the potential molecular mechanism of hub DEGs, GSEA analysis, immune correlation analysis, drug prediction and molecular docking were performed, and transcription factors (TF) and lncRNA-miRNA-mRNA (ceRNA) regulatory networks were constructed.

Results

A total of 48 DEGs with the same expression trend were identified in the MI vs. normal control (NC) and PD vs. NC groups. Functional annotation results showed that the common DEGs were significantly enriched in immune and inflammation-related pathways. RPS4Y1 and UTY were the most relevant hub DEGs for PD and MI, and may be involved in the HALLMARK_MYC_TARGETS_V1 and HALLMARK_PROTEIN_SECRETION pathways. TP63 was a common TF of RPS4Y1 and UTY. The PVT1/KCNQ1OT1-hsa-miR-31-5p-RPS4Y1 and KCNQ1OT1-hsa-let-7a-5p/hsa-miR-19b-3p-UTY axes may play an important role in regulating PD and MI. CYCLOHEXIMIDE and ATALAREN may be potential drugs for the treatment of PD and MI comorbidity. In addition, PD and MI exhibit different patterns of immune cell infiltration and immune function status, which may be related to the specific pathological processes of the disease.

Conclusions

This study revealed for the first time that RPS4Y1 and UTY may be common biomarkers of PD and MI and may be potential therapeutic targets. This study provides new perspective on the common molecular mechanisms between PD and MI.
Health and well-being of staff in substance use services: The case of Scotland
Authors: Bird Joshua , Henning Sarah
Published: February 2025

Background: Addressing high rates of drug and alcohol mortality requires a sustained commitment to supporting a resilient and skilled substance use workforce. Employee well-being in wider health and social care has been the subject of much empirical research, however there is a dearth of evidence specific to professionals working in substance use services.

Methods: Data were derived from a cross-sectional survey of publicly-funded drug and alcohol services operating in Scotland during autumn 2021. Nested semi-log regression models estimated the associations between workplace characteristics and workforce composition, and the main outcome measure: non-Covid sickness absence. Qualitative data were analysed using thematic analysis.

Results: 88 services, representing 43% of Scotland's drug and alcohol services, were included in the study. Factors significantly and positively associated with non-Covid sickness absence in multivariable analysis included average caseload per whole-time equivalent and number of whole-time equivalent clinical roles. Descriptive statistics show that vacancy rates and caseloads are comparatively higher in statutory services, and are also higher for clinical than non-clinical positions.

Conclusion: This study revealed that and burnout leading to sickness absence are serious issues for frontline staff in drug and alcohol services, and these worsened during the Covid-19 pandemic. This research provides a foundation for validating the current findings via future large-scale longitudinal studies, and improving the well-being of people delivering health and social care services in substance use settings.
A possible solution for noise attenuation material for urban buses: The downtown São Paulo case study
Authors: Monteiro Elvis C , Avila Antonio F
Published: February 2025

Urban buses, particularly in large cities, are exposed to significant noise pollution. This paper presents a new family of materials at the micro/nano level designed for urban noise attenuation, specifically for application in urban buses. Melamine foam is combined in series with nanomembranes, creating a composite material that functions as a Helmholtz resonator. As sound waves pass over the nanomembranes, they are disturbed, and the sound resonates within the melamine foam. This interaction reduces the energy of the sound waves and enhances the noise absorption coefficient. In ten cases studied, the average sound absorption coefficient was approximately 89%, with peak frequencies ranging from 2400 Hz to 4300 Hz. The average thickness of the nanomembranes was around 5.0 µm, while the melamine foam had a thickness of 13 mm. The mean noise reduction achieved was about 11 dB, which depends on factors such as the morphology, thickness, and pore size of the nanomembranes. A case study conducted in downtown São Paulo demonstrated that applying these materials to urban buses can significantly reduce interior noise levels. Finally, the proposed system is fully scalable and adaptable for various applications where acoustic insulation is required.
Barriers and Challenges for Digital Twin Adoption in Healthcare Supply Chain and Operations Management
Authors: Sharma Anil Kumar , Srivastava Manoj Kumar , Sharma Ritu
Published: February 2025

The healthcare sector has undergone significant changes in recent times due to the implementation of digitalization and Industry 4.0 technology. Digital Twins (DTs), which are virtual replicas of physical objects, products and/or services, have the potential to become a significant competitive advantage within the healthcare industry. Our present study aims to fill the existing research gap and contribute to the advancement of DT in healthcare supply chain and operations management by finding the barriers for DT adoption. We achieved this by synthesizing relevant literature and conducting a systematic literature review. We have further categorized the barriers using the Technology-Organization-Environment (TOE) framework as the outcome of the research, both as a theoretical contribution and to assist industry practitioners in focusing on barriers specific to their domain for the successful implementation of DT technology. The future research avenues are proposed based on the identified barriers.
“They Don't Even Know How Ethnocentric They're Being”: Comparative Approaches to Worldview Diversity Education
Authors: Bowling Renee L.
Published: February 2025

Is diversity education in international education ethnocentric? Viewed from a critical internationalization studies lens, how diversity work is framed, crafted, or exported has the potential to ‘other’ alternate worldviews and reinforce neocolonial relations in international higher education. Conversely, global diversity education offers an opportunity to collectively reimagine internationalization as otherwise, encouraging mutuality in theorizing and contextualization in praxis. This article presents findings from a sequential exploratory comparative case study of approaches to worldview diversity education that combined a representational survey with elite interviews of global liberal arts campus leaders, unearthing commonalities as well as critiques of Global North dominance in international diversity, equity, inclusion, justice and belonging (DEIJB) work. In amplifying the leaders’ common expressions of worldview diversity education and highlighting their critiques and recommendations for practice, this article offers global perspective to enhance epistemic justice in the conceptualization and delivery of global diversity education.
Hypertrophic osteopathy in 4 white-tailed deer, with a literature review
Authors: Weyna Alisia A. W. , Luley Erin , Brown Justin D. , Niedringhaus Kevin D. , Gibbs Samantha E. J. , Nemeth Nicole M.
Published: February 2025

Hypertrophic osteopathy (HO) is a condition in which periosteal bone forms along long bone diaphyses and metaphyses. Lesions generally affect all 4 limbs, and often involve the distal portions. The pathogenesis is incompletely understood, and many, but not all, cases are associated with concurrent neoplasia or space-occupying masses. Among veterinary species, most cases are reported in dogs, cats, and horses, with sporadic cases in other domestic and non-domestic species. In cervids, this condition is often associated with fungal granulomas, typically in the lung. We report HO, with findings consistent to other veterinary species, in a farmed white-tailed deer (WTD) with bacterial pneumonia and in 3 free-ranging WTD, one of which had fungal pneumonia. Recognition of HO in WTD and potentially associated conditions can lead to improved sample collection in the field. Such information can improve characterization of the disease, complement our understanding of comparative pathology of this condition, and raise awareness among individuals or institutions working with cervids.
How to Use Data Science in Economics – A Classroom Game Based on Cartel Detection
Authors: Wallimann Hannes , Sticher Silvio
Published: February 2025

Background

Conceptual links between economics and modern data science pose challenges for students and lecturers alike. The present article aims to enhance education and training of students and practitioners by integrating modern empirical research skills into their economic competencies.

Aim

This paper introduces a classroom game designed to simulate real-world economic scenar- ios, enhancing understanding of procurement markets and regulatory roles within society. In addition, the paper provides supporting teaching material in order to implement the game. The incorporation of this classroom game can contribute to the preparation of the next generation of professionals to be better equipped to address challenges in the era of big data.

Method

Participants’ success in the game’s first two parts hinges on their comprehension of market dynamics. In the third part, drawing from recent literature on machine-learning-based cartel detection, participants analyze whether bid patterns are indicative of collusive (cartel) behavior. In this part of the game, the success of the participants now role-playing as employees of an antitrust authority, depends on data-science skills.

Results

The classroom game introduced in the present article was implemented with a class of ten students, serving both as a proof of concept and as a means to gain practical insights. The game proves to be a suitable tool for social-science educators to incorporate the interdisciplinary nature of modern economics into their curricula. It is suited for participants with varying levels of data-science expertise. Moreover, it demonstrates how key lessons from scientific articles can 1 be taught in an application-oriented manner, enhancing participants’ ability to apply theoretical knowledge in real-world contexts.

Conclusion

Incorporating the classroom game presented in this paper into educational curricula supports students in effectively integrating data-science skills with economic reasoning.
Family Coping Among Patients With Heart Failure: A Qualitative Study
Authors: Zhang Xiong , Zhou Min , Zhou Huilin , Zhang Yimei , Jin Xiaorong , Su Xu , Wei Wei , Bai Yangjuan , Ma Fang
Published: February 2025

Heart failure is a severe and terminal stage of various heart diseases characterized by complex clinical syndromes. With regard to the management of HF, the patient’s family is the most common and essential resource. The manner in which the family copes with the disease can lead to effective or ineffective management. It is necessary to explore how families of patients with heart failure as a whole are coping with the disease. Our qualitative descriptive study involved 18 families of patients with HF, including 18 patients and 13 family members. Based on the trichotomy of coping strategies proposed by Weiten, the text of the interviews was analyzed via content analysis. Four categories emerged from the data: (1) problem-oriented coping, (2) appraisal-oriented coping, (3) emotion-oriented coping, and (4) family dynamic–oriented coping. Nine subcategories were extracted: fighting the disease during an episode; managing the disease in daily life; embarking on a journey for support; understanding the disease in a diverse way; accepting the disease or not, optimistic; worried and powerlessness; alternating role responsibilities; and adjusting family interactions. The identification of the predominant category of ‘family dynamic–oriented coping’ in our study has significant implications for health care professionals. By recognizing and addressing the unique dynamics of family interactions and coping mechanisms, health care providers can develop targeted strategies to improve overall outcomes for both patients and their families impacted by HF.
Working from home is associated with lower odds of inflation stress Among employed US adults in the Household Pulse Survey
Authors: Bather Jemar R , Pagán José A , Furr-Holden Debra , Goodman Melody S
Published: February 2025

Background

Recent shifts in hybrid working practices have coincided with rising prices, potentially inducing inflation-related stress among employees.

Objective

To investigate associations between remote work status and self-reported inflation-related stress among employed US adults in an overall sample and stratified by gender identity and race/ethnicity.

Methods

We pooled data across 15 survey cycles (September 2022-October 2023) from the US Census Bureau Household Pulse Survey. Remote work status was measured as 0, 1–2, 3–4, and 5 + days. Covariates included age, marital status, education, income, number of children, employment sector, region, and survey cycle.

Results

The weighted sample comprised 48,686,575 individuals (0 days = 24%, 1–2 days = 23%, 3–4 days = 15%, and 5 + days = 38%), with 93% who self-reported stress related to inflation. Among the overall sample, employed individuals working remotely for 5 + days (adjusted OR [aOR] 0.87, 95% CI 0.80, 0.95) had lower odds of self-reported inflation stress than workers with zero remote workdays. Similar associations were found among males (aOR 0.87, 95% CI 0.78, 0.98), females (aOR 0.87, 95% CI 0.76, 0.99), White individuals (aOR 0.84, 95% CI 0.77, 0.93), and individuals of other race/ethnicity (aOR 0.58, 95% CI 0.37, 0.90). We did not find any statistically significant remote work associations with self-reported inflation stress among Black, Hispanic, and Asian individuals.

Conclusions

Our findings have important implications for occupational health, elucidating a potential positive relationship between remote work and inflation stress. These findings can inform how organizations shape their hybrid-working policies to minimize financial stress on employees.
Test of the Social Cognitive Model of Well-Being Among Vocational Education and Training Students in Spain
Authors: Hernandez-Arriaza Marta , Muñoz-San Roque Isabel , Aza-Blanc Gonzalo , Arribas-Marin Juan
Published: February 2025

This study aimed to test the model of academic well-being based on the Social Cognitive Career Theory in 368 Spanish higher Vocational Education and Training students, incorporating the variable academic interests. A cross-sectional design assessed self-efficacy, outcome expectations, interests, social and academic support, and academic and life satisfaction. All instruments showed consistent reliability with the original English and Spanish versions. The hypothesised model produced a good fit to the data and accounted well for variance in academic satisfaction (82%) and life satisfaction (43%). All hypothesised direct effects were significant except for three, for which indirect and total effects were significant. These results reinforce the cross-cultural validity of the model and the instruments, demonstrating the relevance of self-efficacy, outcome expectations, and social and academic support in VET students’ academic satisfaction. Furthermore, they highlight the importance of academic interests as mediators between self-efficacy and outcome expectations in predicting academic satisfaction. It is suggested that procedures be implemented to enable the students to enrol in studies of their interest and improve their well-being.
Livernet based segmentation of lesions from computed tomography scan for liver tumor detection
Authors: Kumar Priyan Malarvizhi , Gohel Hardik , Selvaraj Jeeva , Kavin Balasubramanian Prabhu
Published: February 2025

Millions of lives could be saved annually if liver tumours could be detected early with computed tomography. But it's a huge strain for radiologists to read hundreds or even tens of these CT scans. Therefore, developing an autonomous, rapid, and reliable method of reading, detecting, and assessing CT scans is important. However, extracting the liver region from CT scans is a bottleneck for any approach. This paper introduces a three-part automatic process. Initial processing includes noise suppression and image enhancement. Optimized Bi-lateral Filtering is used to carry it out; in this case, the process's control parameters are optimized using the Monarch butterfly optimization method. After that, automatic liver segmentation and lesion identification are performed. Mask-Region-based Convolutional Neural Network segment liver from the pre-processed images. Then a new generator network named LiverNet is used to detect tumors within the liver. Finally, an Enhanced Swin Transformer Network employing Adversarial Propagation distinguishes between malignant and benign liver lesions. Positive developments were discovered as a result of the inquiry. Expert results are associated with the consequences of segmentation and analysis. The classifier makes a relatively accurate tumour differentiation and gives the radiologist a second opinion.