bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluctuating Currents: Balancing urban growth and restoring native riverine synergies in Mumbai — the case of Dahisar River
Authors: Nayak Ajay , Keluskar Kimaya , Pawar Vikram
Published: October 2023

In 1690 CE, a transformation was initiated by the British East India Company on the seven islands along India's western coast. These islands, once primarily Portuguese territories featuring indigenous communities deeply intertwined with rich ecological and cultural histories spanning millennia, underwent a gradual metamorphosis into the major metropolis known as 'Bombay,' a trajectory that persists today in its rebranded identity as 'Mumbai.' This article delves into how the commonly accepted imaginations of urban utopia progressively turned away from the perceived stagnant waters of rivers and estuaries that, in reality, served as vital coastal ecological buffers. The expansion of Mumbai city propelled its citizens, particularly marginalised low-income groups and traditional settlement inhabitants, towards the outskirts where vestiges of natural ecosystems endure. This shift granted them rudimentary necessities such as water and outdoor spaces, including prospects for agriculture. The convergence of socially vulnerable communities with ecologically delicate zones frequently led to heightened intricacies and debilitation, placing immense stress on both the city's ecological and social resources. This article centres on the examination of urban rivers, using the Dahisar River, a representative seasonal watercourse in Mumbai, as a focal point. Through this exploration, it seeks to scrutinise the multifaceted networks intertwined with Mumbai's river systems, emphasising the urgency of recalibrating perceptions of rivers in Indian urban landscapes. The study also reflects upon the tumultuous socio-political dynamics of the city, involving governing bodies, indigenous stewards, urban residents, and industries. Amid the array of potential solutions, technical and ecological facets often take a backseat to the socio-political determination required to adopt a more ecologically conscious stance. Nonetheless, optimism persists, as climate change mitigation and urban well-being emerge as entrepreneurial prospects for the nation's economic hub. The national leadership aims to position itself as a catalyst for change, aligning with global ecological narratives on the political stage.
America’s Intracoastal Waterway: Understanding the nation through narratives about infrastructure
Authors: Pinnix Aaron
Published: October 2023

Traversing the Atlantic and Gulf Coasts of the United States, the Intracoastal Waterway comprises 4828 km of protected canals, with 3218.7 km running from Boston to the Florida Keys, and 1609 km running from Carrabelle, Florida to Brownsville, Texas. Often used by commercial vehicles, especially in the transportation of petroleum and petroleum products, the canal gets understood and discussed within American society in a variety of ways. Reading across different texts, I explore how the Intracoastal Waterway has been narrativised, including within a lineage of settler-colonialism, as an ecologically disruptive infrastructure project and as a space for life-affirming encounters. Among these texts I find two dominant modes of narrativising this infrastructure project, each of which impact our understanding of it and, by extension, the nation. Hegemonic narratives emphasise the canal’s place within a nation-wide history of colonisation, while local narratives emphasise the ecology, history, and people surrounding the canal. Altogether, by considering these different approaches we get a complicated understanding of how America gets understood, both locally and at the national level, through the stories told about its infrastructure.
The Recovery of Disused Waterways as Blue Corridors: The Battaglia Canal between Padua and the Venetian Lagoon
Authors: Zecchin Lisa
Published: October 2023

The management of surface freshwater bodies can be considered one of the most important issues affecting the quality of living spaces in the industrialised world. Today's awareness of the importance of sustainable water management includes the artificial canals built over centuries to meet multiple and different needs. The development of railways in the 19th century and the extraordinary spread of road transport after World War II led to the steady abandonment of historic canals all over Europe and the consequent deterioration of their water quality and corridor spaces. This deterioration, in turn, led to socio-cultural conflicts over the spaces and the necessity/desirability of maintaining them in the late 20th century. In recent years the benefits provided by blue-green infrastructure in terms of biodiversity, new socio-economical opportunities and the improvement of the well-being and mental health of their users has been acknowledged by scholars and policy makers in the European Union and elsewhere. The article analyses the territorialisation of the Battaglia Canal in Italy’s northwestern Veneto region, between Padua (Padova) and the Venetian Lagoon and its broader canalscape that has resulted from different adminsitrative and planning processes and the manner in which changes in socio-environmental perceptions has influenced approaches to managing the canal. Building on this, the article raises issues concerning the management of the canal and proposes some perspectives for a multifunctional recovery and a sustainable valourisation of it as a social and environmental asset.
A Clinical Case Presentation - A Review Study
Authors: Shraddha Sharma  , Manoj Kumar Sharma  , Ratnesh Kumar Shukla  , Ayushi Mogra  , Veenu Yadav
Published: October 2023

Clinical case presentation is essential feature in medical science as it works as a guideline for new researchers. It includes each and every aspect related to patients. There are different type of clinical researches which is based on the work done in particular disease. The purpose of clinical research is to discover answers to questions through the application of scientific procedures. Clinical Research test, how will new approaches and interventions work in people, these approaches can be medical, behavioral or management oriented. The clinical study helps to prevent, screening, diagnose, manage and answer scientific questions about diseases. A clinical case presentation is a case report of symptoms scientific diagnosis treatments and follow up of an individual patient. Finally, the case report should be connected to existing literature, mentioning the message that the case conveys. The review should narrow down to the source of confusion or main challenge in the case.
Kesha Shareera as per Acharya Charaka - A conceptual study
Authors: Harshavrdhan V. Byalihal
Published: October 2023

The main aim of Ayurveda is to maintain the health of an individual and treat illness if occurs. As Samyavasthata of Dosha disturbs and illness occurs, the structures and functions of body alters as Dosha influences Dhatu accordingly. The study of these structures acts as criteria to understand the health and illness of a person and one among such structure of health or disease is Kesha. Kesha being one such parameter of health, description about it regarding its formation, characteristics, variation according to different body constitution (Prakruti), beneficial and harmful factors for Kesha, its maintenance, importance in clinical diagnosis and prognosis of a disease etc. is available in Ayurveda. In this article, an attempt is made to understand Kesha Sharira and its concepts according to Charaka Samhita.
Comparative study of clinical evaluation of Tab. Bhumiamalaki Ghanavati and Tab. Norfloxacin in the management of Pittaja Mootrakruccha w.s.r. to Urinary Tract Infection
Authors: Nikita Sanjay Nigal
Published: October 2023

Background: Prevalence and incidence of urinary tract infection (UTI) is higher, and caused by the invasion of microorganisms in the genitourinary tract. Most common causative organism is E-coli. Occurring commonly in females due to short urethra. UTI can be correlated with Mootrakruccha (dysuria) which is elaborated by Acharya Charaka in Trimarmiya Chikitsa Adhyaya. Pittaja Mootrakruccha occurs due to vitiation of Pitta Dosha, mostly seen in patients receiving Pitta Prakopaka Ahara and Vihara. Common symptoms are Sadaha (burning), Sashula (painful) and Muhurmuhu (frequency) Mootrapravritti (micturation). Aim: To do comparative study of clinical evaluation of Bhumiamalaki Ghanavati and Tab. Norfloxacin in the management of Pittaja Mootrakruccha w.s.r. to UTI. Materials & Methods: In this study, 60 patients were equally divided by simple random sampling method into Group A administered with Bhumiamalaki Ghanavati (250mg-2 BD) having cooling, antispasmodic, analgesic property and Tab. Norfloxacin (400mg - BD) to Group B for 10 days, respectively. The primary outcomes were measured by chi-square test and run test for interpretation of subjective and objective criteria. Observation and Results: Findings of 30 patients in each group revealed that in group A, relief of 63.63%, 65% and 56.86% was observed in Sadaha, Sashula and Muhurmuhu Mootrapravritti complaint, respectively. Conclusion: Administration of Bhumiamalaki Ghanavati shows significant improvement on subjective and objective criteria.
Preparation of Ksharasutra: A Comprehensive Study on Selection, Preparation and Processing
Authors: Jakaria Ahmed  , Pankaj Kumar Barman  , Champak Medhi
Published: October 2023

The Ksharasutra is a specialized Ayurvedic surgical thread renowned for its efficacy in treating anorectal disorders, particularly fistula-in-ano. This paper aims to provide a comprehensive overview of the preparation process of Ksharasutra, focusing on the selection of thread, preparation of Kshara, collection of Snuhi Ksheera, the Ksharasutra cabinet, and the method of sealing. Through a detailed explanation of these essential steps, the purpose of this paper is to enhance the understanding of the complex and comprehensive method involved in developing the Ksharasutra.
Retinitis Pigmentosa - An Ayurvedic View
Authors: Sandeep Anand P.
Published: October 2023

Retinitis Pigmentosa is a genetically determined dystrophy of the retina, almost invariably occurring in both the eyes. Beginning in childhood and often resulting in blindness in middle or advanced age. Night blindness is also one of the features of retinitis pigmentosa, Naktandya is seen in Kapha Vidagda Drishti, Nakulandya, Hriswajadya and Doshandya. The age of onset, rate of progression, eventual visual loss and associated ocular features are frequently related to the mode of inheritance. RP may occur as an isolated sporadic disorder, inherited as autosomal dominant (AD), autosomal recessive (AR), or X-linked. Retinitis Pigmentosa should be considered as Triteeya Patalagata Roga. The involved Dosha is Vata Pradhana Tridosha. Sodhana Karma and Kriyakalpas judiciously used not only improve the circulation but also provide micronutrients to the retina there by preventing the deterioration of retina.
A clinical study of Gokshuradi Vati in the management of Gestational Hypertension
Authors: Shashi Bharti  , Vidya Sagar Ram
Published: October 2023

Introduction: Ayurveda, an ancient health science, holds potential for addressing contemporary health challenges. This study explores the efficacy of Gokshuradi Vati, an Ayurvedic formulation, in managing gestational hypertension, a pressing concern in modern pregnancy. Methods: A total of 20 patients were recruited from a medical institution. Patients were divided into two groups: Group A (Gokshuradi Vati) and Group B (Methyl Dopa). The study assessed the effects of the therapies on systolic and diastolic blood pressure, edema, headache, disturbed sleep, oliguria, and abnormal weight gain. Data were analyzed statistically to determine the therapies' efficacy. Results: Both Group A and Group B exhibited significant reductions in systolic and diastolic blood pressure after treatment. Gokshuradi Vati demonstrated notable reduction in diastolic blood pressure, pedal edema, headache, disturbed sleep, and abnormal weight gain. Methyl Dopa and Gokshuradi Vati showed comparable relief in systolic blood pressure, edema on other body parts, and oliguria. Follow-up results sustained Gokshuradi Vati's effects. Discussion: This study underscores the potential of Ayurvedic interventions in managing gestational hypertension. Gokshuradi Vati's efficacy without adverse effects presents a complementary approach to conventional treatments. The integration of Ayurvedic insights with modern medical challenges highlights a comprehensive path towards healthcare solutions for pregnant women. Conclusion: Gokshuradi Vati demonstrates promise in managing gestational hypertension. Further research on a larger scale is recommended to validate these findings and to contribute to holistic healthcare solutions for pregnant women.
An Ayurvedic approach on Bad Obstetric History w.s.r. to Putarghani Yonivyapad: A Case Study
Authors: Manisha Kumari  , Jitesh Kumar Panda  , Suniti Tanwar
Published: October 2023

Introduction: Spontaneous pregnancy loss can be physically and emotionally taxing for couples, especially when faced with recurrent losses. Recurrent pregnancy loss (RPL), also referred to as recurrent miscarriage or habitual abortion, is historically defined as 3 consecutive pregnancy losses prior to 20 weeks from the last menstrual period. Based on the incidence of sporadic pregnancy loss, the incidence of recurrent pregnancy loss should be approximately 1 in 300 pregnancies. In Ayurveda Putraghni Yonivyapad is described where repeated abortions or the early neonatal deaths are explained which are due to Artava Dosha, Rakta Dosha, Raktastrava and Raktakshaya. When we came across with descriptions given by different Acharyas we come to know that these all points came under the Bad Obstetric History described in modern science. As we all know that Ayurveda is a science of life. Methods: In the present case study, a 34 years old women patient consulted to the OPD with the complaints of recurrent pregnancy loss in first trimester [5 Abortions]. Her hematological and sonographic reports were normal. Diagnosis was unexplained. She was supposed to be treated with Ayurvedic Shodhan and Shaman therapy. Result: Only Ayurvedic protocol were used during the course of the treatment. After this, patient conceived after 3 months of treatment, and no evidence of abortion was found. She delivered a healthy baby. Discussion: The present study shows the role of Ayurveda in bringing a positive result in the management of Putraghni Yonivayapad.
Role of Mundi Taila on Anovulatory Factor - A Case Study
Authors: Vasundhra  , Jitesh Kumar Panda  , Suniti Tanwar
Published: October 2023

Infertility is defined as inability to conceive with minimum one year of regular unprotected coitus. In Ayurveda, Vandyatwa is a condition where a female fails to conceive and unable to continue pregnancy. Bheda and Chikitsa of Vandyatwa is mentioned in Ayurvedic text. There may be many of reasons for this condition to cause. Anovulation factor is described as a cause of infertility. Ovulation is under the control of Vata. In current study, an effort has been made to study the effect of Uttarbasti on anovulation. A 27 years of Patient of female infertility having anovulatory factor being diagnosed by TVS for 2 consecutive cycles. Patient is administered the Uttarbasti through Mundi Taila.
Effect of Marma Chikitsa in the management of Udavarta Yonivyapad (Primary Dysmenorrhea)
Authors: Niharika Jaiswal  , Rita Marwaha  , Nisha Bhalerao  , Basanti Guru
Published: October 2023

Marma Chikitsa is very useful in present era specially in pain management. While describing Sharir Rachna different Acharya has described about Marma and vital regions of the body. Marma Sthan is a confluence on body where two or more structures Mamsa, Sira, Snayu, Asthi or Sandhi. In human body many structures have Prana (Vital Power) these are known as Marma and Pranayatana. These Marma Sthan harmonize the nervous and endocrine system and normalize different pathology in the body through vital power itself, with proper stimulations/manipulation. This technique is known as Marma Chikitsa. Marma Chikitsa is an ancient Indian practice whose purpose is stimulations / manipulation of vital energy (Prana) in the body for enhancing the healing process. Marma’s knowledge helps the clinicians to regulate the flow of Prana through the coarse and subtle bodies in order to restore the patient’s health and serenity. All authorities of Ayurveda have described Udavarta Yoni Vyapad and it’s management. Dysmenorrhea means painful menstruation which can be corelated with Udavarta Yoni Vyapad. It occurs in 50% of post pubescent females. Dysmenorrhea literally means painful menstruation but a more realistic and practical definition includes case of painful menstruation of sufficient magnitude so as to incapacitate day to day activities. Primary Dysmenorrhea refers to menstrual pain without pelvic pathology. Udavarta Yoni Vyapad is characterized by painful menstruation. According to Charak, Rajas is pushed in upward direction by the aggravated Vayu due to obstruction in its normal flow (Anulomana Gati) in Pakwashya.
High Origin of Profunda Femoris Artery - A Case Report
Authors: Harshavrdhan V. Byalihal  , Niyaz B. Kanavi  , Shwetha
Published: October 2023

Profunda Femoris Artery arises from lateral aspect of femoral artery 3.5cm distal to inguinal ligament. Profunda femoris Artery gives lateral circumflex and medial circumflex femoral arteries from lateral and medial aspect of femoral artery respectively. Following variation was reported in left lower limb of a 62-year male cadaver, during routine dissection of Rachana Shareera dissection class. Profunda Femoris Artery arises from lateral aspect of femoral artery 1.5 cm distal to inguinal ligament, runs laterally and down words parallel to femoral artery, the profunda femoris passed beneath rectus femoris, sartorius and vastus medialis successively in its course, later pierced adductor magnus, 5.5 cm above knee joint.
Leech Application in Varicose Ulcer: A Single Case Study
Authors: Zahidul Islam  , Namita Baishya  , Champak Medhi  , Binod Kalita
Published: October 2023

A female patient aged 47 Years from Lankeswar, Guwahati, Assam approached Shalya OPD of Govt. Ayurvedic College and Hospital, Guwahati with complain of an ulcer over the left lower leg with pain and swelling since 6 months. Pain was very intense and whole foot was swollen. She was suffering from varicose vein in both the legs since 1 year. Family history was positive for varicose vein. On examination antero-posterior aspect of ankle joint ulcer was noticed. The ulcer was characteristically covered by unhealthy granulation tissue with slough, pus and foul smell. Color Doppler revealed partial SPJ incompetence in left leg. Case was diagnosed as a chronic unhealed varicose ulcer. After proper investigation the patient was planned for Jalukaavacharana to evaluate the efficacy of Jalaukavacharan in the management of Dushta Vrana. Total 4 settings of Jalaukavacharana was done.
Comparative Pharmacognostical & Phytochemical Study of Kodrava (Paspalum scrobiculatum) & Mandua (Eleusine coracana)
Authors: Shweta Verma  , Sachin Yadav  , Tuhin Kumar
Published: October 2023

Reference of Kodrava (Kodo millets) and Mandua (Eleusine coracana) can be well traced in different Samhitas. Acharya Charaka described Kodrava, where it was indicated in disorders of Kapha and Pitta.[1] In Nighantus, Kodrava and Mandua (Finger millets) both mentioned as Laghu, Swadu, Katu Vipaka, Lekhniya, Ruksha, Vatapittaprakopaka.[2] Many plants have been described in Ayurveda in them Ahara holds greater medical importance, this study is an attempt to compare the Pharmacognostical and Phytochemical evaluation between the Kodrava and Mandua, as here the peoples of Uttarakhand called Kodo (Kodrava) and Mandua are same and shopkeepers also knows Kodo in the name of Mandua only. So, on the basis of their Pharmacognostical and Phytochemicals profiles., one can differentiate both the drugs. The Macroscopy and Microscopy of seeds of both the plants were studied as per standard procedures. The powders of both the drug’s seeds used in the experimental study to ascertain its Rasa by dilution method. Both the parts shows the same Rasa i.e., Madhura and Kashaya, Virya Sheet and almost same morphological and microscopical characters like Aleurone layer with Starch grains and oil droplets was present. Embryo can be seen clearly in both the drugs. The dissimilar character in both the drugs was Epithelial cells with Air space and thick walled Endosperm cells present in EC but not in PS. Hence it is concluded that both drugs are different with same family Poaceae.
An inclination of Prakriti towards Obesity - An Observational Study
Authors: Jagriti Singh  , Ram Manohar , Mishra Shweta , Mishra Manish
Published: October 2023

Sthaulya described as notorious disorder is mentioned by Acharya Charaka in Ashtauninditia Purusha. Acharya Charaka and Vagbhatta mentioned that Karshya (thin) is better than Sthaulya Vyadhi, however involvement of Vata and Pitta, cannot be neglected. Kapha Dosha is associated mainly due to its Ashrayashrayi Sambandha to Meda. In this study, we have tried to evaluate the interrelationship between Prakriti and Sthaulyta. More prevalence of Sthaulya in patients having Kapha predominant Prakriti pointed towards involvement of Kapha Dosha in pathophysiology of Sthaulya. Study also shows that people of urban areas are more obese than that of rural areas, because of unsystematic diet, junk food, lake of exercise, disturbed life style etc. Individual with Kaphaj Constitution have smoothness of organs and joints, clarity of complexion, firmness, compactness, and stability of the body.
Efficacy of Tonsenorm Compound in the management of Tundikeri with special reference to Chronic Tonsillitis in Children
Authors: Ashok Kumar Pushkar  , Rakesh Kumar Nagar  , Prabhakar Vardhan  , Savita Pushkar  , Shraddha Kumawat  , Simmi Rani  , Rajkumar
Published: October 2023

Introduction: Tonsillitis is one of the most common infectious conditions in the paediatric age group. Symptoms such as pain or tenderness in the throat, fever, tonsillar swelling with a white or yellow coating, painful blisters or ulcers on the throat, headache, loss of appetite, ear pain, trouble swallowing, bad breath, a scratchy or muffled voice, and a stiff neck mentioned in this disease. Ayurveda addresses the problem of Tundikeri, similar to chronic tonsillitis with internal medicines and external therapies. Tonsenorm compound is such a herbomineral formulation formulated with extract a set of nine drugs. Aim of the proposed study is to evaluate the efficacy of the Tonsenorm compound in Tundikeri. Material and Methods: The present study is planned to be conducted under the strict protocol of an open-label clinical trial, in 40 patients. Tonsenorm compound will be given for 60 days at 250 mg thrice a day. Assessment of the patients will be done on the basis of subjective parameters with a grading/scoring system on every 15th day during the study, with a post-intervention follow-up after 1 month. Results: The result will show the effectiveness of the trial drugs, which will be economical and safe for long-term use in the patients of Tundikeri. Discussion & Conclusion: The outcome of this herbomineral drug change in scoring/ grading of symptoms of Tundikeri /chronic tonsillitis (will be assess after the completion of the trial work).
Assessment of Water Supply System Performance Indicators Based on the Customer Bill-Based Approach
Authors: Sambeto Bibi Takele , Hordofa Dinsa Beyene , Tesseme Aragaw Tamru
Published: October 2023

Significant efforts have been undertaken over the last two decades by governmental organizations and local and international non-governmental sectors to improve water supply and sanitation structures; however, there are significant challenges to the town's growth and expansion. Chiro town's population is increasing, and the community is affected by water and excreta-borne diseases as a result of a lack of proper sanitation facilities and a water supply system. In this study, billed data from Chiro Town water supply service enterprise customers have been used to assess the performance of the water distribution network over ten years (2011-2020). The findings show that the Town's water coverage is 62.9%, the water demand is 8,121.6m3/day, and the computed annual water production is 4,222.3m3/day. Residents of the town have complained about a lack of access to improved drinking water supplies, low water consumption, and sanitation facilities, particularly in the community of those who live in the town's borders and practice open defecation. For all domestic use, 16.32% and 83.68% of respondents used unprotected and protected water sources, respectively. This study suggested that strong sectoral coordination, community involvement, and sufficient financial resources were required to identify the root causes and provide an efficient water supply system in the study area.
BIM Implementation for Storing, Sharing and Capturing Knowledge in Indonesian Project Construction
Authors: Fitra Utama Singgih , Puspa Negara Kartika , Wijatmiko Indradi
Published: October 2023

BIM as a digital representation of assets has been used to facilitate design, construction, and operation process to form a reliable basis for decisions. While knowledge is part of the company's assets, knowledge will be maintained in the system so that it may be recalled if needed if BIM is used to document, store, and distribute knowledge more easily. This study will determine how BIM adoption supports knowledge storage, knowledge share, and knowledge capture in Indonesian construction projects. Data was obtained by interview and analysed using qualitative method. The results showed that large state-owned construction companies in Indonesia had implemented BIM-based knowledge management to assist organisational knowledge management process, especially in knowledge capture, storage and share on several projects, and reduce knowledge loss due to time lapse. Finding also shows that knowledge created in a project is centralised in one model, and lessons or knowledge can be grouped with BIM user preferences.
The Impact of Optimal Glycemic Control on Tuberculosis Treatment Outcomes in Patients With Diabetes Mellitus: Systematic Review and Meta-Analysis (Preprint)
Authors: Zhao Li , Gao Feng , Zheng Chunlan , Sun Xuezhi
Published: October 2023

BACKGROUND

Diabetes mellitus (DM) increases the risk of developing tuberculosis (TB), and optimal glycemic control has been shown to reduce the risk of complications and improve the TB treatment outcomes in patients with DM.

OBJECTIVE

This study aims to investigate the role of glycemic control in improving TB treatment outcomes among patients with DM.

METHODS

MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials databases were searched for randomized controlled trials (RCTs) assessing the impact of oral glycemic control in patients with TB who have DM. Outcomes of interest were radiological findings, treatment success, sputum positivity, and mortality. Evaluations were reported as risk ratios (RRs) with 95% CIs using weighted random-effects models.

RESULTS

The analysis included 6919 patients from 7 observational studies. Our meta-analysis showed significant differences between patients with optimal glycemic control and those with poor glycemic control with regard to improved treatment outcomes (RR 1.13, 95% CI 1.02-1.25; P=.02; I²=65%), reduced sputum positivity (RR 0.23, 95% CI 0.09-0.61; P=.003; I²=66%), and fewer cavitary lesions (RR 0.59, 95% CI 0.51-0.68; P<.001; I²=0%) in radiological findings. There was no significant difference between the 2 groups in terms of mortality (RR 0.57, 95% CI 0.22-1.49; P=.25; I²=0%), multilobar involvement (RR 0.57, 95% CI 0.22-1.49; P=.25; I²=0%) on radiologic examination, and upper lobe (RR 0.94, 95% CI 0.76-1.17; P=.58; I²=0%) and lower lobe (RR 1.05, 95% CI 0.48-2.30; P=.91; I²=75%) involvement on radiologic examination.

CONCLUSIONS

We concluded that optimal glycemic control is crucial for reducing susceptibility, minimizing complications, and improving treatment outcomes in patients with TB with DM. Emphasizing effective health management and health care strategies are essential in achieving this control. Integrating comprehensive care among patients with TB with DM will enhance patient outcomes and alleviate the burden of disease in this population.

CLINICALTRIAL

PROSPERO CRD42023427362; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=427362
Bridging Language Barriers in COVID-19 Research: Descriptive Study of AccesoCovid.com’s Reach and User Engagement (Preprint)
Authors: Abascal Miguel Lucía , Forster Maeve , Gallalee Sarah , Carson Mariam , Fieldhouse Jane K , Keir Alexandra , Maya Sigal , Rahman Sabahat , Reid Michael J A , Vasilopoulos Hariclea , Lima Sanchez Dania Nimbe
Published: October 2023

BACKGROUND

The COVID-19 pandemic underscored the challenge of swiftly disseminating research findings to a global audience. Language barriers further exacerbated disparities in access to timely scientific information, particularly for non-English speaking communities. The majority of COVID-19 research was published in English, limiting accessibility for Spanish-speaking populations.

OBJECTIVE

This paper aims to assess the reach and effectiveness of AccesoCovid.com, a platform designed to disseminate up-to-date COVID-19 research in both English and Spanish, addressing the language gap in scientific communication.

METHODS

AccesoCovid.com was developed through a partnership between the University of California, San Francisco (UCSF) and Universidad Nacional Autónoma de México (UNAM). The website’s performance and user engagement were evaluated using Google Analytics over a span of 2 years. Key metrics included user language preference, geographical distribution, and site traffic. The website summarized and translated 1032 articles on various COVID-19 topics, such as “Pharmaceutical Interventions and Vaccines.”

RESULTS

From February 2021 to February 2023, the platform attracted 57,000 users. Of the 43,000 unique new visitors, 84.2% (n=36,219) hailed from Spanish-speaking regions. The majority accessed the site organically through search engines, with 88.4% (n=38,000) of users arriving this way, while 5000 (11.6%) users accessed the site directly. Most users (n=30,894, 72.1%) preferred the Spanish version of the site. The website’s most accessed category was “Pharmaceutical Interventions and Vaccines,” followed by “Clinical Presentation and Management” and “Mental Health.” Regarding language distribution, 72.1% (n=30,894) of users primarily used Spanish; 21.4% (n=9215) used English; and 6.7% (n=2891) spoke other languages, including Portuguese, Chinese, and German. Geographically, the website attracted visitors from 179 countries, with the highest visitor counts from Mexico (n=12,342, 28.7%), Spain (n=6405, 14.9%), the United States (n=4416, 10.3%), and Peru (n=3821, 8.9%).

CONCLUSIONS

AccesoCovid.com successfully bridged a critical language gap in the dissemination of COVID-19 research. Its success underscores the pressing need for multilingual scientific resources. The platform demonstrated significant user engagement and reach, particularly in Spanish-speaking countries. This highlights the potential for similar platforms to ensure equitable access to scientific knowledge across diverse linguistic communities. Future efforts should focus on expanding to other languages and conducting formal evaluations to enhance user satisfaction and impact.
Tobacco Smoking or Nicotine Phenotype and Severity of Clinical Presentation at the Emergency Department (SMOPHED): Protocol for a Noninterventional Observational Study (Preprint)
Authors: Campagna Davide , Farsalinos Konstantinos , Costantino Giorgio , Carpinteri Giuseppe , Caponnetto Pasquale , Cucuzza Francesca , Polosa Riccardo ,   SMOPHED Study Group
Published: October 2023

BACKGROUND

In the last few years, several nicotine products have become available as alternatives to smoking tobacco. While laboratory and limited clinical studies suggest that these devices are less toxic compared to classic tobacco cigarettes, very little is known about their epidemiological impact. Visiting the emergency department (ED) often represents the first or even the only contact of patients with the health care system. Therefore, a study conducted at the ED to assess the impact of these products on health can be reliable and reflect a real-life setting.

OBJECTIVE

The aim of this noninterventional observational study (SMOPHED study) is to analyze the association between the severity of clinical presentation observed during ED visits among patients using various nicotine products and the subsequent outcomes, specifically hospitalization and mortality.

METHODS

Outcomes (hospitalization and mortality in the ED) will be examined in relation to various patterns of nicotine products use. We plan to enroll approximately 2000 participants during triage at the ED. These individuals will be characterized based on their patterns of tobacco and nicotine consumption, identified through a specific questionnaire. This categorization will allow for a detailed analysis of how different usage patterns of nicotine products correlate with the clinical diagnosis made during the ED visits and the consequent outcomes.

RESULTS

Enrollment into the study started in March 2024. We enrolled a total of 901 participants in 1 month (approximately 300 potential participants did not provide the informed consent to participate). The data will be analyzed by a statistician as soon as the database is completed. Full data will be published by December 2024.

CONCLUSIONS

There is substantial debate about the harm reduction potential of alternative nicotine products in terms of their smoking-cessation and risk-reduction potential. This study represents an opportunity to document epidemiological data on the link between the use of different types of nicotine products and disease diagnosis and severity during an ED visit, and thus evaluate the harm reduction potential claims for these products.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/54041
Deep Blue
Authors: Kadam Ameya Bhavesh
Published: October 2023

Abstract: Deep Blue is a chess machine or in simple language it is a chess engine made by the top programmers of IBM. The purpose of this research is to review the famous Deep Blue Chess engine which defeated Garry Kasparov, the famous World Chess Champion in a six – game match in 1997. Following are the main features of the Deep Blue: A single chip chess engine. A massively parallel system with multiple level of parallelism. A strong emphasis on search extension. Effective use of grandmaster’s game database. This research paper will describe a Deep Blue system and give all the interesting information about this chess engine along with all the other few important Chess engine. Why deep blue only? – Deep blue is the first chess engine who defeated The World Chess Champion Garry Kasparov in 1997
Student Performance Prediction
Authors: Thorat Prof. Madhuri , Sonawane Nilesh , Bhore Shubham , Doiphode Santosh , Sunkewar Vinayak
Published: October 2023

Abstract: Assessing student’s learning performance is a fundamental aspect of evaluating educational systems, playing a pivotal role in addressing challenges within the learning process and measuring learning outcomes. The emergence of educational data mining (EDM) as a research field has harnessed the power of data and knowledge to enhance education systems. EDM involves the development of techniques to analyze data collected from educational environments, offering a more comprehensive understanding of students and facilitating improvements in educational outcomes. The integration of machine learning (ML) technology has witnessed substantial growth, enabling researchers and educators to leverage data mining insights to predict and simulate educational processes, including success rates, dropouts, and more. This research paper explores the analysis of students' performance through data mining methods. It employs classification technique to discern the early-stage impact on GPA. In the classification methodology, various machine learning models are experimented with to predict student performance in the early stages, incorporating diverse features such as course grades and admission test scores. The paper employs different assessment metrics to evaluate model performance. The findings underscore the potential of educational systems to proactively address the risk of student failures during their initial stages of education
Use of production process simulation as a verification tool
Authors: Kopec Jan , Pekarcikova Miriam , Mizerak Marek , Trojan Jozef
Published: October 2023

This article deals with the use of manufacturing process simulation as a verification tool. Simulation proves to be a valuable tool for testing and evaluating production processes and their effectiveness in a controlled virtual environment. The authors discuss the advantages that simulation brings, such as the identification of defects, the optimization of production parameters, and the prevention of problems even before the start of the real production process. The use of simulation of the production process enables the acquisition of valuable knowledge about the influence of various factors on the final product quality, the optimization of production procedures, and the minimization of the risk of errors. The authors emphasize that the simulation provides accurate information that helps in the decision-making process and allows the prediction of possible problems and their solutions before they arise.
Concepções de estudantes sobre o Clube de Ciências: aspectos relevantes para sua implantação em uma escola pública de Ibirité/MG
Authors: RODRIGUES M. F. R. , COSTA F. J.
Published: October 2023

Science Clubs can be considered as enabling strategies for an active and significant development of teaching and learning processes and also of scientific practices. The present objective research will present conceptions of students of a public school in the Municipality of Ibirité, in Minas Gerais, about the Science Club and the stages of the scientific method. The data received by the participants came from the filled semi-structure participants. As the quali-quantitative research allowed in students to know about the Science Club and scientific research, but little about scientific research, they have a great interest in participating and understanding more of them. In this way, it becomes relevant to propose the implantation of a Club in the referred school for the development of proposals and activities that collaborate with the scientific formation of the students considering the aspects evidenced in this work.
Vírus, saúde e pandemia: um estudo sobre as concepções alternativas de escolares do ensino fundamental
Authors: SOUZA A. R. , SILVA C. D. D. , GOMES M.J.P.O. , SANTOS D. B.
Published: October 2023

Viruses are constantly worked on in the teaching of Science and Biology and are part of one of the themes that are associated with human health, and which became even more evident after the pandemic caused by covid-19. The range of complementary information from digital, television and social media leads students to present different knowledge and impressions on this theme, which often do not present elements of coherence with scientific knowledge about viruses, their characteristics and predicted in health. In view of this reality, this study aimed to analyze the alternative conceptions of elementary school students about viruses. Data collection was carried out with 31 students from the 6th year of a private school in the municipality of Pau dos Ferros, RN. For this, a questionnaire sent by google forms containing 17 open and closed questions on the theme was used. It was found that students have basic conceptions about viruses and that the media has a strong influence on the establishment of ideas on the theme. It was also noticeable that some students have a certain confusion between viruses and microorganisms in general, and especially between what is a disease and what is a symptom. In general, this work can serve as a reference for new studies, especially for teachers who seek to understand the diverse conceptions of scholars about microorganisms, aiming to explore diverse didactic strategies, allowing an improvement in the teaching and learning process in science, especially in science. area of ​​viruses relating to human health.
Hepatitis aguda grave inmunomediada por pembrolizumab: a propósito de un caso
Authors: C Stehli , F Cabrera , P Lucero , I Gutiérrez Magaldi
Published: October 2023

La inmunoterapia contra el cáncer con inhibidores del punto de control inmunitario ha sido ampliamenteaceptada como un enfoque terapéutico novedoso. Sin embargo, en algunos casos pueden generarautoinmunidad con eventos adversos graves, tales como la hepatitis aguda inmunomediada. Se presenta elcaso de una paciente con antecedente de cáncer renal de células claras en estadio IV, en tratamiento conPembrolizumab/ Axitinib, que debuta con hepatitis aguda grave tras un mes de terapia. El laboratorioevidenció parámetros de insuficiencia hepática con patrón colestásico. Se descartó compromiso de vía biliarpor medio de colangio-resonancia Magnética. Las serologías virales y anticuerpos antinucleares fueronnegativos, mientras que la proteinograma por electroforesis resultó normal. Se realizó tratamiento conmetilprednisolona 250 mg endovenoso y medidas de sostén, con lo cual el paciente evolucionófavorablemente con mejoría del estado general y de los valores de laboratorio. Se destaca la importancia dela exclusión de otras etiológicas de hepatitis grave como parte de la disquisición diagnóstica, así como sutratamiento oportuno en pacientes con tratamiento con Pembrolizumab, ya que generalmente se obtiene unabuena respuesta con la suspensión del fármaco y con corticoterapia a altas dosis.
Key roles of Ubiquitination in Regulating Critical Regulators of cancer stem cell functionality
Authors: Guo Qianqian , Qin Hai , Chen Zelong , Zhang Wenzhou , Zheng lufeng , Qin Tingting
Published: October 2023

The ubiquitin (Ub) system, a ubiquitous presence across eukaryotes,
plays a crucial role in in the precise orchestration of diverse cellular
protein processes. From steering cellular signaling pathways and
orchestrating cell cycle progression to guiding receptor trafficking and
modulating immune responses. The dysregulation of Ub-mediated signaling
pathways in prevalent cancers ushers in a spectrum of clinical outcomes
ranging from tumorigenesis and metastasis to recurrence and drug
resistance. Ubiquitination, a linchpin process mediated by Ub, assumes a
central mantle in molding cellular signaling dynamics. It navigates
transitions in biological cues and ultimately shapes the destiny of
proteins. Recent years have witnessed an upsurge in the momentum
surrounding the development of protein-based therapeutics aimed at
targeting the Ub system under the sway of cancer stem cells (CSCs). The
article provides a comprehensive overview of the ongoing in-depth
discussions regarding the regulation of the Ub system and its impact on
the development of CSCs. Amidst the tapestry of insights, the article
delves into the expansive roles of E3 Ub ligases, deubiquitinases
(DUBs), transcription factors entwined with CSCs. Furthermore, the
spotlight turns to the interplay with pivotal signaling pathways the
Notch, Hedgehog (Hh), Wnt/β-catenin, and Hippo-YAP signaling pathways
all play crucial roles in regulation of CSCs following by the specific
modulation of Ub-proteasome.
Shirley Jackson'ın Distopyası “Piyango”da Konformizm ve Gelenek
Authors: Işık Onur
Published: October 2023

Güney Gotiği geleneğinden gelen Shirley Jackson'ın ünlü hikayesi “Piyango” belirsiz bir zaman diliminde Amerika’nın güneyindeki bir kasabada her yıl düzenli bir şekilde gerçekleştirilen piyangoyu konu edinir. Konformist ve geleneksel toplum eleştirisini sembolik ve toplumsal unsurlar üzerinden yapan hikâye kadim siyah kutudan çekilen kartla önce bir ailenin seçilmesiyle başlar. Bunun ertesinde de aileden kimin taşlanacağını belirlemek için ikinci bir çekiliş yapılır. Seçilen kişi tüm kasaba halkı tarafından taşlanarak öldürülür. Jackson'ın kullandığı ironi, sembolizm ve kullanılan dil öykünün sarsıcı etkisine katkıda bulunur. Şu bir gerçek ki geniş çaplı eleştiriler yapan ve rahatsız edici distopik bir hikâye olan “Piyango” en sıradan toplulukların bile şiddete meyilli olabileceğini göstererek insan doğasının konformizm karşısındaki zayıflığını gözler önüne serer. Karakterleri, mekânı ve anlatı yapısını analiz eden bu çalışma, hikâyede tasvir edilen gelenek, sosyal dinamikler ve insan doğası arasındaki karmaşık ilişkilere ışık tutarak gelenekleri körü körüne takip eden bir toplum üzerinden konformizmin ve aykırı düşüncenin çatışmasını ve bu çatışmanın sonuçlarını tartışmayı amaç edinir.
Analisis Ergonomika Pengoperasian Bagian Pencacah pada Mesin Pencacah Pakan Ternak Multiguna
Authors: Anggiana Ayu , Suharyatun Siti , Wisnu Febryan Kusuma , Warji Warji
Published: October 2023

The multi-purpose animal feed chopping machine is one of the feed chopping tools that many farmers use to help speed up the chopping of raw materials that will be used as animal feed. The chopping machine can be operated optimally if the machine is ergonomic so that it is safe and comfortable to operate. This study aims to analyze the ergonomics of a multi-purpose animal feed chopper in terms of anthropometry, operating workload and the level of work fatigue specifically for the chopper. This research uses quantitative methods which are supported by literature studies regarding the design of creating machine dimensions. The parameters in this study are: (1) anthropometric data consisting of Standing Finger Tip Height (TJUB), Standing Vertical Reach (JVB), and Standing Horizontal Reach (JHB); (2) the recommended weight limit that can be lifted by the operator (RWL), and (3) cardiovascular load (CVL). The research results stated that the height of the chopper hopper (100 cm) was classified as ergonomic because it was still between TJUB (66.10 cm) and JVB (183.95 cm). The operator's position from the hopper should not exceed JHB (66.00 cm). The recommended load limit (RWL) is 5.38 kg. Operation of the machine chopper section does not cause work fatigue with an average CVL of 10.71% (≤ 30%). Keywords: Anthropometry, CVL,  Pulse Rate, RWL, Work Fatigue.
Mempelajari Pembuatan Tepung dari Buah Pepaya sebagai Bahan Baku Makanan
Authors: Oktavia Nur , Tamrin Tamrin , Rahmawati Winda , Kuncoro Sapto
Published: October 2023

Papaya is one of the fruits that are liked in the community because of it has a sweet taste and rich in vitamin C. In Indonesia papaya is abundant and the price of it is relatively low so that papaya gets wasted easily.  Therefore, it is necessary to process the product to extend the shelf life and increase the value-added papaya fruit. Papaya flour is a product  of  new  innovations  of  flour  from  the  fruit  besides  papaya  flour  is  food processed products to increase the value-added agricultural produce. In this study used the temperature treatment and type of papaya,  with successive research procedures namely taking papaya fruit, peeling, slicing, soaking, drying, grinding, and sieving. The results showed that the temperature of drying can affect the moisture content of papaya flour, color, aroma, and vitamin C. The best quality of papaya flour is at 70°c, which is 23 with the desired color and aroma, resulting in an average water content of 4.9678% and vitamin C content that tends to be higher with a value of 420, 0667 (mg/100g). Drying with papaya type treatment does not significantly affect the moisture content of flour, color, aroma and vitamin C content. Keywords: Aroma, Drying, Flour, Papaya, Vitamin C