bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunomodulation of adipose-derived mesenchymal stem cells on peripheral blood mononuclear cells in colorectal cancer patients with COVID-19
Authors: Wang Jun-Feng , Yang Xiao-Xia , Zhang Jian , Zheng Yan , Zhang Fu-Qing , Shi Xiao-Feng , Wang Yu-Liang
Published: May 2024

BACKGROUND

Accumulating evidence has shown that adipose tissue-derived mesenchymal stem cells (ADSCs) are an effective therapeutic approach for managing coronavirus disease 2019 (COVID-19); however, further elucidation is required to determine their underlying immunomodulatory effect on the mRNA expression of T helper cell-related transcription factors (TFs) and cytokine release in peripheral blood mononuclear cells (PBMCs).

AIM

To investigate the impact of ADSCs on the mRNA expression of TFs and cytokine release in PBMCs from colorectal cancer (CRC) patients with severe COVID-19 (CRC+ patients).

METHODS

PBMCs from CRC+ patients (PBMCs-C+ ) and age-matched CRC patients (PBMCs-C) were stimulated and cultured in the presence/absence of ADSCs. The mRNA levels of T-box TF TBX21 (T-bet), GATA binding protein 3 (GATA-3), RAR-related orphan receptor C (RORC), and forkhead box P3 (FoxP3) in the PBMCs were determined by reverse transcriptase-polymerase chain reaction. Culture supernatants were evaluated for levels of interferon gamma (IFN-γ), interleukin 4 (IL-4), IL-17A, and transforming growth factor beta 1 (TGF-β1) using an enzyme-linked immunosorbent assay.

RESULTS

Compared with PBMCs-C, PBMCs-C+ exhibited higher mRNA levels of T-bet and RORC, and increased levels of IFN-γ and IL-17A. Additionally, a significant decrease in FoxP3 mRNA and TGF-β1, as well as an increase in T-bet/GATA-3, RORC/FoxP3, IFN-γ/IL-4, and IL-17A/TGF-β1 ratios were observed in PBMCs-C+ . Furthermore, ADSCs significantly induced a functional regulatory T cell (Treg) subset, as evidenced by an increase in FoxP3 mRNA and TGF-β1 release levels. This was accompanied by a significant decrease in the mRNA levels of T-bet and RORC, release of IFN-γ and IL-17A, and T-bet/GATA-3, RORC/FoxP3, IFN-γ/IL-4, and IL-17A/TGF-β1 ratios, compared with the PBMCs-C+ alone.

CONCLUSION

The present in vitro studies showed that ADSCs contributed to the immunosuppressive effects on PBMCs-C+ , favoring Treg responses. Thus, ADSC-based cell therapy could be a beneficial approach for patients with severe COVID-19 who fail to respond to conventional therapies.
Loss of heterozygosity for chromosomes 16q in Wilms tumors predicts outcomes: A meta-analysis
Authors: Song Yuan-Hua , Li Wen-Ling , Yang Zhen , Gao Yan , Feng Zhi-Ping
Published: May 2024

BACKGROUND

The research findings suggest that the prognosis of children with Wilms tumor (WT) is affected by various factors. Some scholars have indicated that loss of heterozygosity (LOH) on chromosome 16q is associated with a poor prognosis in patients with WT.

AIM

To further elucidate this relationship, we conducted a meta-analysis.

METHODS

This meta-analysis was registered in INPLASY (INPLASY2023100060). We systematically searched databases including Embase, PubMed, Web of Science, Cochrane, and Google Scholar up to May 31, 2020, for randomized trials reporting any intrapartum fetal surveillance approach. The meta-analysis was performed within a frequentist framework, and the quality and network inconsistency of trials were assessed. Odds ratios and 95%CIs were calculated to report the relationship between event-free survival and 16q LOH in patients with WT.

RESULTS

Eleven cohort studies were included in this meta-analysis to estimate the relationship between event-free survival and 16q LOH in patients with WT (I 2 = 25%, P < 0.001). As expected, 16q LOH can serve as an effective predictor of event-free survival in patients with WT (risk ratio = 1.95, 95%CI: 1.52–2.49, P < 0.001).

CONCLUSION

In pediatric patients with WT, there exists a partial correlation between 16q LOH and an unfavorable treatment prognosis. Clinical detection of 16q chromosome LOH warrants increased attention to the patient’s prognosis.
Association of complement components with risk of colorectal cancer: A systematic review and meta-analysis
Authors: Zhu Xiao-Lin , Zhang Lu , Qi Su-Xia
Published: May 2024

BACKGROUND

Complement components could contribute to the tumor microenvironment and the systemic immune response. Nevertheless, their role in colorectal cancer (CRC) remains a contentious subject.

AIM

To elucidate the relationship between complement components and CRC risk and clinical characteristics.

METHODS

Searches were conducted in PubMed, the Cochrane Library, and the China National Knowledge Infrastructure database until June 1, 2023. We included cohort studies encompassing participants aged ≥ 18 years, investigating the association between complement components and CRC. The studies were of moderate quality or above, as determined by the Agency for Healthcare Research and Quality. The meta-analysis employed fixed-effects or random-effects models based on the I² test, utilizing risk ratio (RR) and their corresponding 95% confidence interval (CI) for outcomes. Sensitivity and subgroup analyses were performed to validate the robustness of the collective estimates and identify the source of heterogeneity.

RESULTS

Data from 15 studies, comprising 1631 participants that met the inclusion criteria, were included in the meta-analysis. Our findings indicated that protein levels of cluster of differentiation 46 (CD46) (RR = 3.66, 95%CI: 1.75-7.64, P < 0.001), CD59 (RR = 2.86, 95%CI: 1.36-6.01, P = 0.005), and component 1 (C1) (RR = 5.88, 95%CI: 1.75-19.73, P = 0.004) and serum levels of C3 (standardized mean difference = 1.82, 95%CI: 0.06-3.58, P = 0.040) were significantly elevated in patients with CRC compared to healthy controls. Strong expression of CD55 or CD59 was associated with a higher incidence of lymph node metastasis, whereas strong CD46 expression correlated with a higher incidence of tumor differentiation compared to low CD46 expression (P < 0.05 for all). Although specific pooled results demonstrated notable heterogeneity, subgroup analyses pointed to regional differences as the primary source of inconsistency among the studies.

CONCLUSION

Our analysis underscores that increased levels of specific complement components are associated with a heightened risk of CRC, emphasizing the potential significance of monitoring elevated complement component levels.
Multidisciplinary comprehensive treatment of massive hepatocellular carcinoma with hemorrhage: A case report and review of literature
Authors: Kou Xian-Shuai , Li Fan-Fan , Meng Yun , Zhao Jian-Ming , Liu Sheng-Fen , Zhang Lan
Published: May 2024

BACKGROUND

Hepatocellular carcinoma (HCC), a major contributor to cancer-related deaths, is particularly prevalent in Asia, largely due to hepatitis B virus infection. Its prognosis is generally poor. This case report contributes to the medical literature by detailing a unique approach in treating a large HCC through multidisciplinary collaboration, particularly in patients with massive HCC complicated by ruptured bleeding, a scenario not extensively documented previously.

CASE SUMMARY

The patient presented with large HCC complicated by intratumoral bleeding. Treatment involved a multidisciplinary approach, providing individualized care. The strategy included drug-eluting bead transarterial chemoembolization, sorafenib-targeted therapy, laparoscopic partial hepatectomy, and standardized sintilimab monoclonal antibody therapy. Six months after treatment, the patient achieved complete radiological remission, with significant symptom relief. Imaging studies showed no lesions or recurrence, and clinical assessments confirmed complete remission. This report is notable as possibly the first documented case of successfully treating such complex HCC conditions through integrated multidisciplinary efforts, offering new insights and a reference for future similar cases.

CONCLUSION

This study demonstrated effective multidisciplinary treatment for massive HCC with intratumoral bleeding, providing insights for future similar cases.
Model-Based Knowledge Management in HV Battery Development
Authors: Badi Ibtihal , Braun Andreas , Kallis Lena
Published: May 2024

In the dynamic landscape of battery development, the quest for improved energy storage and efficiency has become paramount. The contemporary energy transition, coupled with growing demands for electric vehicles, renewable energy sources, and portable electronic devices, has underscored the critical role that batteries play in our modern world. To navigate this challenging terrain and harness the full potential of battery technology, a well-defined and comprehensive data strategy resp. knowledge management strategy are indispensable. Conversely, the imminent and rapid progression of artificial intelligence (AI) is poised to have a substantial impact on the forthcoming landscape of work and the methodologies organizations employ for the management of their knowledge management (KM) procedures. Conventional KM endeavors encompass a spectrum of activities such as the creation, transmission, retention, and evaluation of an enterprise’s knowledge over the entire knowledge lifecycle. However, these efforts frequently overlook the ongoing advancements within the domain of AI. Consequently, organizations grapple with the integration of AI into their operational milieu to harness enhanced efficiency in outcomes.

This paper will draw upon the tenets of the already established KM strategies in AVL High Voltage Energy Systems Team and Al-centric paradigm tailored for the implementation of KMS within organizational frameworks. Our proposed approach serves to fortify the foundations of KM strategy by outlining the ways in which AI interfaces with existing operational procedures. This, in turn, enables a comprehensive comprehension of the potential roles AI could assume in the intricate interplay between knowledge workers and AI systems.
Fry, Edwin Maxwell (1899–1987)
Authors: Cormier Leslie Humm
Published: May 2024

Edwin Maxwell Fry, architect of modern British design and liberal social theory, brought insight to early 20th century Britain and to the global community. Fry’s work was dedicated to design theory and construct for the working class, for urban dwellers, for children, and, notably, for refugees and intellectual émigrés. With the British design firm Isokon, Fry endeavored to save endangered Bauhaus architects and designers, resulting in the British partnership of Gropius & Fry, German refugee and British sponsor. His later partnership was to be Fry & Drew. The primary work of the Gropius & Fry firm was Impington Village College (1936), Cambridgeshire. This ground-breaking open school design represented a social revolution in its time, combining education and community in the visually and socially integrated ‘village college’ concept. Its spreading form has become a norm for 20th century school design from the UK to the USA. Gropius & Fry thus created a major, lasting global design model – in Bauhaus terminology, a true Modern ‘Typeform’ – of contemporary social and educational architecture. For his lifelong dedication to international socially significant architecture, Maxwell Fry was named Commander of the British Empire.
Mills, Florence (1895 or 1896–1927)
Authors: Cubbon Alexandra
Published: May 2024

Florence Mills was a leading African American performer of the Harlem Renaissance. Born in Washington, D.C. in the mid-1890s, Mills was raised in Harlem, New York City, and began performing as a child. During her career as a singer, dancer, and comedian, she performed vaudeville, burlesque, and eventually crossed over into mainstream Broadway, garnering international fame along the way. Mills fought for racial equality throughout her lifetime, using her voice both on and off stage to speak out against racism.

Among the productions Mills starred in, some of the most notable and historic were Folly Town (1920), Shuffle Along (1921), and The Black Birds Revue (1926). Folly Town was among the first racially integrated shows in New York, while Shuffle Along proved that musicals produced by African Americans could appeal to interracial audiences. Mills was also a celebrated singer, whose song ‘I’m a Little Blackbird Looking for a Bluebird’ called for racial justice. Although she died an untimely death in 1927 at the age of 31, Mills’ years of work on the stage challenged contemporary norms around race, class, and gender and contributed to the modernization of theatrical performance.
The Inauguration of the Pleasure Dome (1954)
Authors: Uher Valerie
Published: May 2024

The Inauguration of the Pleasure Dome is a short experimental film by American filmmaker Kenneth Anger, celebrated for its provocative subject matter, surrealistic editing, and opulent, colourful mise-en-scène. Betraying a modernist fascination with occult themes, the film is dedicated to Aleister Crowley, whose Thelema religion inspired many of its characters. A non-narrative film, it portrays mythological, occult and historical figures engaging in ritualised preparations for a pan-sexual bacchanal, which concludes the film. The cast includes erotica author Anaïs Nin, who plays Astarte. Influenced by Soviet filmmaker Sergei Eisenstein’s principles of montage as well as American filmmaker Maya Deren’s filmmaking, Anger uses editing and cinematography to explore the emotional impact of colour, movement, and rhythm. The film begins with slow camera movements and cross fades, zeroing in on the sumptuous props, jewellery, and make-up of the characters. As the revellers become more intoxicated, cuts are more frequent and discontinuous, colours more vivid, and superimposition more prevalent. Through the use of these techniques, Anger experimented with film’s capacity to create an altered consciousness in the viewer. A classic of American experimental film, it was remade by Anger four times over several decades, most famously with Leos Janacek’s Glagolitic Mass as the soundtrack. Anger included it in his compilation of nine films titled the ‘Magick Lantern Cycle’.
Documentary
Authors: Childress Sarah
Published: May 2024

Documentaries involve self-conscious reflections on modern life. Early newsreels and actualities displayed film’s capacity to document events and everyday life as they happened, leading viewers to believe ‘what you see is what there was’ and contributing to documentary’s association with fact and truth. The transition from document to documentary occurred when filmmakers like Robert Flaherty and Dziga Vertov expressed a perspective on what they recorded. This perspective became a way to persuade, especially in national documentaries and propaganda. After World War II, growing scepticism prompted filmmakers to pursue more immediate and spontaneous experiences and invite audiences to interpret material for themselves. Since then, documentaries have highlighted and examined conventions of representation and documentary theory and practice, a process resembling modernism’s questioning of knowledge, authority, and authorship.
The Purpose, Impact and Legacy of the Great Exhibition of 1851.
Authors:   , Ralph Shauna
Published: May 2024

The Great Exhibition of 1851 saw the first world’s fair organised by members of the Society of Arts (such as Henry Cole, and Prince Albert), who later formed the Royal Commission for the Great Exhibition of 1851. In the six months of it being open, the event would attract over six million visitors who came to see displays of machinery, fine art, raw materials, and manufacturing. With over 13,000 exhibits and 100,000 items, those attending this event were able to see first-hand items from countries such as France, Germany, the United States, Russia and exhibits directly from Britain and the Empire. The event proved to be a huge success, with people coming from all over the world to see the Crystal Palace, and with a profit of over £180,000 as a result. With this profit, the Royal Commission set up educational institutions that still stand today (the Natural History Museum and the Victoria and Albert Museum) demonstrating the long-lasting impact the Exhibition has had.
Exploring Service Accessibility and Quality for Differently-Abled Students: A Qualitative Analysis at a South African University of Technology
Authors: Naidoo Agendri , Adam Jamila Khatoon , Akpa-Inyang Francis
Published: May 2024

This qualitative study investigates the service experiences of differently-abled students within the Financial Aid Department of a prominent South African University of Technology. Employing a semi-structured interview schedule aligned with the Service Quality model (SERVQUAL), five dimensions—tangibles, assurance, empathy, reliability, and responsiveness—are explored. The study unveils the significant challenges students face, including issues related to the location and accessibility of the department, staff approachability, and the reliability of communication systems. The discussion section draws on relevant literature to synthesise the findings, providing comprehensive insights into the intricacies of service delivery for differently-abled students. The study concludes with actionable recommendations for enhancing service quality and inclusivity, addressing the unique needs of this student demographic in the evolving landscape of South African higher education.
Elaboración de adoquín ecológico utilizando plástico y arena para pavimento en calle Los Reyes del Distrito La Esperanza, Provincia de Trujillo
Authors: Sisniegas Gálvez Paul Alexis , Ninaquispe Zare Viviano Paulino , Gregorio Mayer Ascon Dionicio , Martell Ortiz Juan Carlos , Vásquez Salazar Oscar Daniel , Vásquez Díaz José Laureano
Published: May 2024

El trabajo de investigación tuvo como objetivo elaborar un adoquín ecológico utilizando plástico y arena para pavimento en la calle Los Reyes del Distrito La Esperanza, provincia de Trujillo; teniendo en cuenta dos aspectos: la proporción de material y las propiedades físico – mecánicas.El tipo de investigación es explicativo – cuantitativo y el diseño de investigación es experimental. La población son los adoquines convencionales de concreto; y los adoquines ecológicos de plástico PET y arena. La muestra fue no probabilística por conveniencia empleándose 16 adoquines en total (8 adoquines de concreto convencional y 8 adoquines de plástico PET y arena). La técnica de recolección de datos fue la observación directa o exploración in situ, el análisis documental e instrumentos de la NTP. Esto permitió analizar su resistencia a compresión, peso y medida. La validación de los instrumentos de recolección de datos se efectuó gracias al juicio de expertos a través de tres ingenieros de la especialidad. Se tuvo como resultado que el adoquín convencional, tiene una resistencia menor que el adoquín ecológico fabricado con 95% de plástico PET y 5% de arena, que las dimensiones están dentro de las tolerancias establecidas por la norma técnica peruana 399-611. Por lo que se concluye que si es posible elaborar un adoquín de plástico PET y arena.
HIGH TECH-ENGINEERING JOURNAL
Authors: Benedicto XVI Universidad Católica de Trujillo
Published: May 2024

High Tech- Engineering Journal es una revista de acceso abierto revisada por pares, orientada a la publicación de artículos científicos de ingeniería. La periodicidad de nuestros volúmenes es semestral, en línea y está a cargo de la Universidad Católica de Trujillo Benedicto XVI-Vicerrectorado de Investigación en coordinación con la Facultad de Ingeniería y Arquitectura. Esta revista surge por iniciativa de docentes y estudiantes de esta casa superior de estudios con el propósito de difundir el conocimiento científico, producto de la investigación.
Modelo teórico-metodológico para el estudio de la subjetividad en estudiantes universitarios
Authors: Guerrero Azpeitia Luis Arturo
Published: May 2024

Partiendo de la premisa de que tanto subjetividad como objetividad no sólo son parte de una misma realidad, sino que no se pueden comprender ni explicar una sin la otra, es que en este libro se presenta una aproximación para el estudio de la subjetividad, particularmente, en estudiantes universitarios. Para ello, se parte de la formación de estudiantes universitarios desde una perspectiva de la subjetividad, se presentan una serie de argumentos y reflexiones que permiten contextualizar, desde un posicionamiento sociocultural, rasgos de subjetividad tales como las emociones, los valores, la ética y la equidad de género. Posteriormente, se revisan posicionamientos teórico-conceptuales sobre la subjetividad y la objetividad, vistas incluso de manera antagónica por un sector de especialistas, pero también y prioritariamente, se focaliza sobre una perspectiva relacional, incluso dialéctica entre ellas, es en este contexto que se recupera la teoría de la economía de las prácticas sociales de Bourdieu como un eje articulador para la integración de un modelo teórico-metodológico de aproximación al estudio de la subjetividad. Dicho modelo, integra, por una parte, una perspectiva comparada, así como técnicas cuantitativas tales como el análisis multivariante pero también recupera técnicas cualitativas como las entrevistas y los marcos interpretativos principalmente; de esta manera se reconoce que la objetividad a partir del sentido objetivo aunado a la subjetividad conceptualizada a través del sentido de lo vivido son elementos que permiten abordar las prácticas sociales de los agentes considerando en todo momento, el estrecho vínculo con la espacio-temporalidad.
Entre la tradición patria y la modernidad cinética. El cruce aéreo de los Andes en la prensa argentina (1914-1921)
Authors: Guiamet Javier
Published: May 2024

Este artículo analiza la cobertura en la prensa masiva argentina de los primeros cruces aéreos de la cordillera de los Andes en los años que van de 1914 a 1921. Enmarcadas en un imaginario sobre el progreso científico y el avance moderno y civilizatorio, las narrativas desplegadas y recogidas por la prensa conjugaron también una apelación a la tradición patria y encumbraron nuevos héroes populares fruto de la espectacularización de las hazañas. Considerando esto, el artículo rastrea los diversos sentidos, imaginarios y apropiaciones presentes en la cobertura periodística, en un tiempo signado por la necesidad de reafirmar la identidad nacional y proyectar un país moderno.
Lo que el fuego no se llevó. La orfebrería mixteca como tributo, 1526-1530
Authors: Rivero Hernández Iván
Published: May 2024

Una vez sujetada la región y establecido el régimen de encomiendas, los señoríos de las Mixtecas Alta, Baja y de la Costa debieron tributar a los españoles parte de su mano de obra y bienes en especie. Entre estos últimos destacó el oro, fuera en su estado natural, en tejos o en joyas. El presente texto centra la atención en estas últimas contribuciones, particularmente valiosas si se piensa en la gran destreza de los orfebres mixtecos. Estos tributos en joyas se estudian, además, en relación a un periodo sumamente temprano, incluso anterior a las conocidas tasaciones de tributos que han permeado tanto en la historiografía sobre el periodo colonial temprano de Nueva España.
Pueblos, estancias y ganado. Cambios y conflictos por los nuevos usos y formas de tenencia de la tierra. Valle de Oaxaca, siglo XVI
Authors: Cruz López Beatriz
Published: May 2024

Este artículo muestra cómo la cría de ganado europeo se abrió paso en el Valle de Oaxaca y cuáles fueron los conflictos tempranos que esta nueva actividad productiva generó, tanto por los daños que ocasionaban los animales, como por las nuevas formas de legitimar la tenencia de la tierra. El análisis de litigios, juicios, cartas de compraventa, mercedes y otras fuentes tempranas muestra algunos mecanismos usados por los españoles para apropiarse de tierras. También las estrategias de la población nativa para salvaguardar sus personas y bienes, defender sus tierras, e incluso cuestionar los argumentos usados para legalizar el nuevo régimen de propiedad que buscaba implantarse, como el de los baldíos o tierras realengas. Algunas alianzas temporales entre pueblos y facciones de colonizadores lograron amortiguar algunos efectos no deseados que la ganadería trajo. Aunque efímeras, estas victorias permitieron que los pueblos se adaptaran y posteriormente incursionaran en esta actividad económica.
Passenger Rolling Stock of Indian Railways in the First Half-Century of Their Operation
Authors: Zakharov V. B. , Komarov E.
Published: May 2024

In India, as in many countries, railways originated as industrial gauge tracks for the transportation of ore, timber, stone, and other building materials. These were the first industrial railways in India to deliver supplies to construction sites, in particular, Chintadripet in Madras (1835), Red Hill Railroad line (1837), Godavari Dam Construction Railway (1845), and others. Initially, the promoters of the construction of railways, based on the general social and economic situation in the country, did not count on the development of passenger traffic, taking into account the virtually impoverished situation of the vast majority of the population. Efforts were focused on freight transportation. The colonialists proceeded from the need to develop railways as an important exploitation tool for exporting the country’s natural resources to the parent country and to the world market. Throughout almost the entire period of British colonial rule, passenger transportation was intended for a narrow stratum of colonizers and a few of the richest representatives of the country’s indigenous population. By the 1860s, there was a system of dividing passenger traffic on the railways of India into four classes. Saloon coaches were used to serve the ruling elite. The difference in travel conditions in luxury saloon coaches and first-class compartment carriages in comparison with third- and fourth-class carriages was huge. It reflected the social class structure of Indian society. At the same time, railway passenger transportation did not affect the interests of the majority of the population at all, as with their level of wealth they could not afford to travel by rail at all, remaining outside the line of progress in transport of the 19th century.
Experience of Russian-Chinese industrial cooperation on the construction of the Moscow metro
Authors: Kivlyuk V. P. , Paschenko A. I. , Konyukhov D. S. , Xue Liqiang , Zhou Jimin , Vinogradov S. N. , Orlov K. V. , Song Yangchun , Huo Jiuyuan , Lyu Yongfang , Gu Zhiqiang , Wang Ting
Published: May 2024

The commissioning of the Big Circle Line in Moscow, some sections of which were laid jointly with Chinese underground builders, provided the first experience of interaction with foreign construction contractors on the Moscow Metro. The paper investigates this experience which is of value for the development of such works in the future. The analysis was carried out on the basis of scientific and technical documentation on certain facilities, the progress and results of construction and installation works, and information on other events. The paper describes the facilities where construction and installation works were carried out by joint efforts and shows the peculiarities of interaction between Russian and foreign (Chinese) metro builders on a number of sections of the Big Circle Line of the Moscow Metro. The achieved results are demonstrated by the example of individual underground stations. The study reveals the peculiarities of material and technical support of works on the sections constructed by Chinese construction contractors. The mutual exchange of experience, technologies, and work management practices along with the application of various tunnel boring machines from both countries (Russia and the PRC) has yielded fruitful results, demonstrated the possibility and efficiency of the direct engagement of foreign tunnel builders at Russian sites in close cooperation with their Russian counterparts, and revealed a scheme for rational division of labour, work management, and logistical support of works.
Scientific support for the design and construction of high-speed railway lines. Chronicle of the Development of Competencies for High-Speed Railway Transport in Russia
Authors: Valinsky O. S. , Kisеlev I. P.
Published: May 2024

The construction of the first high-speed railway in Russia is long overdue. Such a project would be an organic continuation and a new turn in the one and a half century history of Russian railway workers’ struggle to increase train speeds on the country’s railways.
The specific features of the values and meaning domain and motivation of future specialists in the transport industry
Authors: Cerfus D. N.
Published: May 2024

Currently, the problem of training highly skilled, competitive specialists equipped with competencies necessary for their future professional activity is of particular relevance. This is key to building a talent pipeline in the transport industry in general and in the railway sector in particular where the activities of the majority of workers involve providing safety and continuity of operations. One of the topical issues is to study their values and meaning domain and motivational attitudes to their future profession as an opportunity to develop techniques of psychological and pedagogical support aimed at forming stable internal motives and optimizing the professional development of future specialists in the transport industry. The purpose of the study is to explore the specific features of the values and meaning domain and motivation of future specialists in the transport industry. In order to study the purpose-in-life orientations, personality traits and motivation of future specialists in the transport industry, a study was conducted with the participation of 50 people aged 20 to 24 years. The following methods were used: the Purpose-in-Life (PIL) Test by D. Crumbaugh and L. Maholick adapted by D. A. Leontiev; the questionnaire for the assessment of personality traits of a professional (LOP) by I.G. Senin and V.E. Oryol; and the Motivation for Success and Fear of Failure (MUN) method by A. A. Rean. The results for interpretation were obtained by mathematical and statistical data processing using correlation analysis (the Pearson correlation criterion). The sense of purpose in the students is associated with the ability to identify significant conditions for achieving goals and everything that happens to them contributes to their personal growth. The more the students perceive their lives as emotionally intense and interesting, the less they tend to perceive their educational and professional activities as a source of stress. Conclusions: Students with clear goals for the prospects of their future professional self-realisation tend to show internal motives for achieving results to a greater extent. The feeling of meaningfulness and productivity of the students’ lives is associated with tension they experience in the learning process, conscious control of their actions and behaviour.
Analysis of the Effect of Time and Cost Performance Risk of Toll Road Project Based on the Principle of Project Management Body of Knowledge
Authors: Noor Agus Bambang S , Dwiatmoko Hermanto , Amin Mawardi
Published: May 2024

Toll road facilities are needed by the community to improve economic standards with adequate mobility. Toll Road Projects often have delays in the implementation schedule which results in increased project costs. This study aims to determine the effect of the risk of increasing costs on toll road projects caused by delays in project implementation time based on PMBOK guidelines. This research is based on the object of the Japek II Selatan Package III Toll Road project and studies journal literature, surveys, and questionnaires using the SEM Smart PLS program. The effect of risk on cost performance is variable due to the lack of project land readiness. Based on project data from the contract, it was supposed to be completed in December 2020 but was pushed back to mid-2024 estimates. The effect is due to an increase in costs, with a percentage of 2%; in this study, the factor of implementing K3 Projects is in the form of work accident costs. The analysis of SEM PLS shows the effect of time and cost performance on the Planning and Implementation of land readiness indicators, unit price increase, project K3 implementation, and risk management implementation. The study concludes that the risk of increasing costs includes poor planning, which is hampered by land readiness and results in delays in implementation time and year differences that cause changes in material unit prices, resulting in an increase in project costs. Risk Management, as stated in the PMBOK guidelines on Toll Road Projects, must be implemented to reduce the impact of the risk of increasing project costs.
The Effect of Extensive Hydrolyzate Formula on the Growth and Development of Infants With Cow's Milk Allergy
Authors: Nuraeni Salsabila Irma , Purnomosari Lupi
Published: May 2024

Cow's milk allergy is a common condition in babies and children. Allergic reactions can occur when the body reacts to the proteins in cow's milk, causing various symptoms such as skin rashes, vomiting, diarrhea, or even more serious reactions. Babies who suffer from cow's milk allergy need appropriate treatment so that their growth and development is not disrupted. One approach used in managing cow's milk allergy is to provide an extensive hydrolyzate formula. The aim of this study was to evaluate the effect of providing extensive hydrolyzed formula on the growth and development of babies suffering from cow's milk allergy. This study used qualitative research methods. The data collection technique in this research is literature study. The data that has been collected is then analyzed in three stages, namely data reduction, data presentation and drawing conclusions. The results of the study concluded that the use of extensive hydrolyzed formula is an effective choice for babies who are allergic to cow's milk. This research shows that this formula has a positive impact on the baby's weight growth according to his age. However, in terms of infant development, there is no significant difference in the effect between the use of extensive hydrolyzed formula and soy protein isolate on various aspects, including global development, gross motor skills, fine motor skills, language and social personality in children who are allergic to cow's milk
The Important Role of Iron, Protein and Vitamin C With the Incident of Anemia
Authors: Dilantika Charisma , Sitorus Nova , Saebah Nur
Published: May 2024

Anemia is a condition where there is a lack of healthy red blood cells. Anemia can be caused by various factors, including deficiencies of iron and vitamin C. The aim of this research is to explore the important role of iron and vitamin C in preventing and treating anemia. This research adopts a qualitative approach in its research methodology. The data collection technique used is literature study. After the data is collected, analysis is carried out in three stages, namely data reduction to identify important information, data presentation to organize relevant information, and conclusion drawing to summarize the findings and their implications. The results showed that iron, protein and vitamin C have important roles in the prevention and treatment of anemia. There is a close relationship between these three components in preventing and treating anemia. Iron deficiency is the root cause of anemia, while vitamin C and protein play a role in increasing iron absorption, thus playing an important role in preventing or treating anemia. Iron is an indispensable mineral for the body to form hemoglobin and myoglobin, which are major components in the transport of oxygen and carbon dioxide. Vitamin C as an antioxidan has a positive effect on immune function and also helps the body absorb iron more easily. So to reduce the risk of anemia, by fulfilling daily protein and then eating foods rich in vitamin C and combining them with iron sources.
The Effect of Prematurity on Children's Cognitive and Psychomotor Development
Authors: Purnomosari Lupi , Opan Fadilah Muhamad
Published: May 2024

Development is something that must occur in living things, including humans. The development that occurs in a child is cognitive and psychomotor development. However, there are several factors that hinder development, one of which is being born prematurely. The purpose of this study was to determine the effect of prematurity on children's cognitive and psychomotor development. The research method used in this research is a literature review with a qualitative approach. The data collection technique is done with documentation. So that the data source used is secondary data. After the data is obtained, data analysis is carried out with Miles & Hubberman interactive analysis through three stages, namely data reduction, data presentation, and conclusion drawing. It was found that prematurity has a significant impact on the development of children's cognitive and psychomotor development as their organs are not fully developed, leading to the risk of complications and impairment of these abilities. So, the importance of cognitive and physical stimulation programs to support the optimal development of children born prematurely
Dark fondas, una opción para mejorar la economía de las mujeres
Authors: Rivera Rojas Carlos de Jesús
Published: May 2024

“En cinco años me veo con mi propio negocio, mis propias ganancias para que yo pueda decidir y hacer más cosas”, fue lo que comentó Noemi, una mujer desempleada de 56 años durante nuestra entrevista (N. Casillas, comunicación personal, noviembre de 2022), quien al mencionar su plan a corto plazo demuestra una clara consciencia de su situación actual y determinación por cambiarla para tomar el control de su futuro.
En los siguientes apartados explicaré las adversidades y circunstancias sociales que han llevado a Noemí y a miles de mujeres más en México a enfrentar una combinación de  desempleo, pobreza laboral, trabajo no remunerado y vulnerabilidad social entre otras fricciones. Finalmente, se plantea un modelo que espera responder a esta problemática a través de la preparación de comida casera como una opción para recuperar su autonomía financiera: el de las dark fondas.
Sientocolor: Diseño de un sistema táctil que le permita a las personas con discapacidad visual identificar los colores de las prendas de ropa de manera independiente
Authors: Tanaka Tsutsumi Harumi Sofía , Díaz Villaseñor Alfonso , Magaña Fajardo Carolina
Published: May 2024

La sociedad ha estandarizado entornos y actividades, lo que causa problemas a quienes no encajan en el promedio, dando paso a la discapacidad. El objetivo de esta investigación es mejorar la experiencia de compra en tiendas departamentales en la Ciudad de México en 2022 para personas con discapacidad (PcD). Se emplea una metodología centrada en las PcD, usando herramientas como el marco AEIOU, LEGO® Serious Play® y dinámicas de co-diseño para fomentar la colaboración y reflexionar sobre el papel de los diseñadores. El objetivo es desarrollar soluciones que faciliten la elección de colores por parte de las PcD, promoviendo un proceso de desarrollo accesible e inclusivo. De esta manera se aumentará la independencia y autonomía de este grupo de la población y reducir las incompatibilidades que surgen de la estandarización social en entornos y actividades.
 
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Semiotic analysis of the relationship between architectural forms and the urban phenomena of segregation and gentrification in Mexico City
Authors: Magaña Fajardo Carolina , Solórzano Zavala Mónica
Published: May 2024

This paper delves into gentrification and segregation in 21st-century Mexico City, connecting a critical visual photo-documentation approach to understanding contemporary urban relationships and social identities. It integrates Charles Morris' triadic model (syntactic, semantic, and pragmatic levels) in analyzing photo-documentary images. These models help identify urban elements as visual narratives, contributing to segregation and gentrification. The study focuses on Mexico City, specifically the San Nicolás Totolapan neighborhood, using this method to interpret images in context and assess their impact on constructing meanings and representations. The research outcomes offer valuable insights for informed decision-making in architectural and urban design. This work contributes to understanding and addressing the issues of gentrification and segregation in Mexico City's urban landscape.
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Diseño de servicios para personas mayores mexicanas: una experiencia de codiseño en el aula
Authors: García y Colomé G. Ana Paula , Maya Rivero Annika
Published: May 2024

El incremento de la esperanza de vida obliga a repensar cómo proyectamos el mundo que nos rodea, por ello, en la clase de Diseño de Servicios, impartida en el Centro de Investigaciones de Diseño Industrial de la UNAM, se llevó a cabo el proyecto “Codiseño de servicios para personas mayores”, donde participaron nueve mujeres mayores de sesenta años y diecinueve estudiantes de la Licenciatura en Diseño Industrial. El objetivo fue codiseñar servicios para personas mayores partiendo de la definición de oportunidades, bajo la metodología de Diseño de Servicios. Los resultados consistieron en cinco propuestas: plataforma de aprendizaje y socialización, aplicación para planificar y gestionar viajes, programa de gobierno para promoción y venta de productos artesanales y manualidades, gimnasio para mayores, y un servicio de comida saludable a domicilio.
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Upskate: construcción de comunidad a través del skate y el diseño
Authors: Norzagaray Natera Andrea
Published: May 2024

Este escrito documenta y comparte los hallazgos encontrados en el codiseño e implementación de Upskate: taller del upcycling de tablas de skate que tuvo como objetivo fomentar los vínculos entre las personas que comparten el interés por el skate en el área de influencia de CENTRO. Los participantes transformaron sus tablas rotas o astilladas en muebles reaprovechando de esta manera los desechos de esta práctica. Los hallazgos del estudio sugieren que la colaboración entre diseño difuso y experto puede ser una forma eficaz para fomentar la construcción de comunidad. El escrito explora la historia del skate y su relación con la creatividad, el desarrollo del skatepark de Constituyentes y la misión del Hub de diseño social de CENTRO. Posteriormente, describe la metodología, las etapas del proyecto y sus resultados e impacto en ambas comunidades.
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Pensamiento proyectual y hábitat, encuentros y desencuentros desde la educación
Authors: Maldonado Reyes Ana Aurora , Delgado Coellar Alma Elisa
Published: May 2024

El presente trabajo, aborda las relaciones entre pensamiento proyectual y el acto de diseñar, visualizando cómo estas relaciones favorecen, a partir de procesos educativos propios del diseño en el nivel superior, ejercicios de aplicación creativa y el estudio de objetos diseñados, no solo en su carácter material, sino especialmente espacial o discursivo, elaborados por estudiantes de la licenciatura en Diseño Industrial en la FAD/UAEMex y de la licenciatura en Diseño y Comunicación Visual de la FES Cuautitlán/UNAM. Los procesos didácticos se llevan a cabo en torno a los artefactos y el concepto de hábitat como elemento central de relaciones simbólicas, funcionales, estéticas y de sentido del objeto diseñado dentro del ámbito social. Los hallazgos permiten plantear rutas para el abordaje de la educación en diseño favorecedoras del pensamiento proyectual y el aprendizaje contextualizado.
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The Role of Sports Medicine in Preventing and Managing Common Injuries in Athletes
Authors: Kattoof Karrar Yaareb
Published: May 2024

Many international athletic organizations have proposed injury-reduction strategies. These practices include injury screening, emergency medical care, along with injury management measures prior to return-to-play. The extent to which these methods are being adopted in a developing nation like Iraq is uncertain. This paper was contributed to study the role of sports medicine in preventing and managing common injuries in athletes. Our paper focused on the role of sports medicine in treating injured athletes in Iraq. To build up, our methodology’s study was enrolled rate of acute injuries for 80 cases based on organized the demographic characteristics of sports players with three basics which are football, athletics, and handball. The data were analysed using the SPSS program. This study was presented a cumulative analysed and covered all 80 cases during period from 17th January 2022 to 19th March 2023.mThe findings demonstrated a lack of pre-season screening and return-to-play preparedness for all injured athletes. Furthermore, for the majority of injury categories, best practice standards were not followed. This study identified constraints, including sports resource providers' inadequate knowledge, insufficient and insufficiently specialized facilities for treating injured athletes, and policies mandating treatment for injured athletes. These obstacles hinder the implementation of best medical practices.
THE THERAPEUTIC BENEFITS OF ARM MASSAGE IN RELIEVING PAIN AND PREVENTING LYMPHEDEMA AFTER MASTECTOMY
Authors: Venkatesh Mrs. Latha , Kumar J Mr. Sathish
Published: May 2024

Mastectomy is a surgical procedure that involves the removal of breast tissue. It is commonly performed as a treatment option for breast cancer. After the mastectomy, there are different options for breast reconstruction, which is the rebuilding of the breast shape. Reconstruction can be done using implants or the patient's own tissue from another part of the body. Mastectomy is often recommended as a treatment option when breast-conserving surgery is not possible or when the individual prefers to have the entire breast removed. It can be a life-saving procedure and an important step in the journey towards recovery and healing. Arm massage can be really beneficial for patients with mastectomy. It can help relieve pain, improve circulation, reduce swelling, and prevent lymphedema. Massaging the affected arm gently and using techniques like lymphatic drainage can promote healing and enhance overall well-being.