bluuebunny/crossref_metadata_2025 huggingface dataset:
The Dual Carboxymethyl Cellulase and Gelatinase Activities of a Newly Isolated Protein from Brevibacillus agri ST15c10 Confer Reciprocal Regulations in Substrate Utilization
Authors: Maiti Smarajit , Samanta Tanmoy , Sahoo Sumit , Roy Sudipta
Published: December 2017

A protein showing endoglucanase-peptidase activity was prepared from a newly isolated bacterium (ST15c10). We identified ST15c10 as Brevibacillus agri based on electron-microscopic images and its 16S-rDNA sequence (GenBank accession No. HM446043), which exhibits 98.9% sequence identity to B. agri (KZ17)/B. formosus (DSM-9885T)/B. brevis. The enzyme was purified to homogeneity and gave a single peak during high-performance liquid chromatography on a Seralose 6B-150 gel-matrix/C-18 column. MALDI-TOF mass-spectrometry and bioinformatics studies revealed significant similarity to M42-aminopeptidases/endoglucanases of the CelM family. These enzymes are found in all Brevibacillus strains for which the genome sequence is known. ST15c10 grows optimally on carboxymethyl cellulose (CMC)-gelatin (40°C/pH 8-9), and also shows strong growth/carboxymethyl cellulase (CMCase) activity in submerged bagasse fermentation. The purified enzyme also functions as endoglucanase with solid bagasse/rice straw. Its CMCase activity (optimal at pH 5.6 and 60°C/Km = 35.5 µM/Vmax = 1,024U) was visualized by zymography on a CMC-polyacrylamide gel, which provided a strong band of approximately 70 kDa. The purified enzyme also showed strong peptidase (gelatinase) activity (pH 7.2/40°C during zymography on 6-12% gelatin/1% gelatin-PAGE (at approx. 70 kDa). The CMCase activity is inhibited by the metal ions Mn/Cu/Fe/Co (50%), Hg/KMnO4 (100%), and by glucose or lactose (50-75%; all at 1 mM). The observed dose/time-dependent inhibition by Hg ions could be prevented with 2-mercaptoethanol. A comparison of the B. agri endoglucanase-aminopeptidase (ELK43520; 350 aa) with other members of the M42-family revealed the conservation of active-site residues Cys256/Cys260, which were previously identified as metal-binding sites. Regulation of the endoglucanase activity probably occurs via metal binding-triggered changes in the redox state of the enzyme. Studies on this type of enzyme are of high importance for basic scientific and industrial research.
Hypertrophy and Liver Function in ALPPS: Correlation with Morbidity and Mortality
Authors: Kang Danby , Schadde Erik
Published: December 2017

Background: ALPPS (associating liver partition and portal vein ligation for staged hepatectomy) was introduced with the promise to reduce posthepatectomy liver failure (PHLF) in extended hepatectomies but has higher morbidity and mortality rates compared to conventional methods of volume enhancement. There are few studies of the incidence of PHLF after ALPPS and little information on how to avoid PHLF by functional testing. It remains unclear what causes the compromise in liver function despite rapid volume gain and if any of the modifications proposed reduce the incidence of PHLF. This review summarizes published data on this topic. Methods: This is a systematic review that studies literature on the incidence of liver failure and assessment of liver function following ALPPS as well as modifications of the existing technique. Articles were searched in PubMed, evaluated, selected, and tabulated. Results: The literature search revealed 326 articles that met the selection criteria. PHLF criteria as defined by the International Study Group of Liver Surgery (ISGLS) were the most commonly used criteria, but PHLF was frequently not defined. PHLF occurred most frequently after stage 2 of ALPPS at around 30% in most larger studies. Hepatobiliary scintigraphy showed a discrepancy between volume and functional growth of the liver. Function increase was only 50% compared to volume increase. Mechanistic explanations using histologic analyses have been given to explain the immaturity of the liver after rapid hypertrophy. Modifications of ALPPS showed a comparable volumetric gain when compared to classic ALPPS, but data were lacking to assess PHLF. Conclusion: ALPPS has relatively high rates of PHLF, morbidity, and mortality. This may be explained by data demonstrating functional growth when compared to volume growth. ALPPS should not be performed without functional assessment and with caution.
A Comparison of Pitfalls after ALPPS Stage 1 or Portal Vein Embolization in Small-for-Size Setting Hepatectomies
Authors: Schnitzbauer Andreas A.
Published: December 2017

Background: Portal vein embolization (PVE) followed by resection and associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) are tools to enable liver resections in small-for-size settings. Methods: A systematic review of the literature and comparison of pitfalls between PVE and resection and after ALPPS stage 1 were performed. Results: Evidence levels were as low as 4 for both procedures. 20 publications were identified with reports on post-PVE or post-ALPPS stage 1 pitfalls. A total of 2,758 patients treated with PVE followed by resection and 698 patients undergoing ALPPS were analyzed. Pitfalls identified were failure to advance to resection (PVE: high (20%)/ALPPS: low (1%); p = 0.0001), tumor progression (PVE: high/ALPPS: low); insufficient hypertrophy (PVE: frequent/ALPPS: rare), and inter-stage liver failure (PVE: rare/ALPPS: frequent). However, in-house mortality was still very high after ALPPS (7 vs. 3%, p = 0.0001) in a pooled analysis. Conclusion: PVE is a well-established technique to induce hypertrophy in small-for-size settings. The weakness of PVE is that it may fail to advance to resection. Inter-stage liver failure in ALPPS triggers post-stage 2 mortality. Prolongation of the inter-stage interval to overcome liver failure or cancellation of the resection stage combined with adherence to defined indications has the potential to make ALPPS much safer and decrease mortality rates. Level of evidence is low for both techniques.
Topical Coconut Oil in Very Preterm Infants: An Open-Label Randomised Controlled Trial
Authors: Strunk Tobias , Pupala Sameer , Hibbert Julie , Doherty Dorota , Patole Sanjay
Published: December 2017

Background: The immature fragile skin of preterm infants represents an inadequate protective barrier. The emollient and anti-infective properties of coconut oil make it a potentially beneficial topical agent for this population. Objectives: Our aim was to evaluate feasibility, safety, and the effects of topical coconut oil on skin condition in very preterm infants. Methods: An open-label randomised controlled trial in preterm infants <30 weeks' gestation was conducted. Enrolled infants were randomised to receive either routine care or topical coconut oil (5 mL/kg) twice daily for 21 days, starting within 24 h of birth. The neonatal skin condition was the primary outcome, and was assessed using the Neonatal Skin Condition Score (NSCS) on days 1, 7, 14, and 21. The number of coconut oil applications was recorded to assess clinical feasibility and all enrolled infants were monitored for adverse effects of topical coconut application, such as skin irritation. Results: A total of 72 infants born <30 weeks' gestation were enrolled (36 infants per arm), with comparable demographic characteristics. Topical application of coconut oil was feasible and without adverse effects. The NSCS was maintained in the coconut oil group throughout the intervention period, but deteriorated from a median (IQR) of 3 (3-4) on day 1 to 4 (4-4) on day 21 in the control group (p = 0.01). There were no differences in common neonatal outcomes, including sepsis, necrotising enterocolitis, retinopathy of prematurity, chronic lung disease, and mortality. Conclusions: Topical coconut oil maintained a better skin condition in very preterm infants without adverse effects. This simple, safe, and affordable intervention warrants further investigation.
Carvedilol and Cardiac Biomarkers in Dialysis Patients: Secondary Analysis of a Randomized Controlled Trial
Authors: Roberts Matthew A. , Darssan Darsy , Badve Sunil V. , Carroll Robert P. , Fahim Magid A. , Haluska Brian A. , Hawley Carmel M. , Isbel Nicole M. , Marshall Mark R. , Pascoe Elaine M. , Pedagogos Eugenie , Pilmore Helen L. , Snelling Paul , Stanton Tony , Tan Ken-Soon , Tonkin Andrew M. , Vergara Liza A. , Ierino Francesco L. 
Published: December 2017

Background/Aims: Cardiac biomarkers are associated with cardiac abnormalities and adverse outcomes in dialysis patients. Our aim was to report the effect of the beta-blocker carvedilol on cardiac biomarkers in adult dialysis patients. Methods: The Beta-Blocker to Lower Cardiovascular Dialysis Events Feasibility Study was a randomized controlled trial comparing carvedilol to placebo. Serum and plasma were collected before the run-in, then 6 and 12 months post-randomization to measure B-type Natriuretic Peptide (BNP), N-terminal BNP (NT-ProBNP), high-sensitivity cardiac troponins I (hs-TnI) and T (hs-TnT), and galectin-3. Left ventricular global longitudinal strain (GLS) was measured by echocardiography at baseline. Results: Seventy-two participants were recruited of whom 49 completed the run-in and were randomized to carvedilol (n=26) or placebo (n=23). Baseline echocardiography demonstrated median (inter-quartile range) GLS of -14.27% (-16.63 to -11.93). NTproBNP and hs-TnT correlated with GLS (Spearman’s rho=0.34 [p=0.018] and rho=0.28 [p=0.049], respectively). Median change scores from baseline to 12 months did not differ significantly between participants with complete biomarker data randomized to carvedilol (n=15) or placebo (n=16) for any biomarkers. Conclusions: NT-proBNP and hs-TnT were associated with GLS. However, changes in levels of the biomarkers from baseline to 12 months were not different between groups randomized to carvedilol and placebo.
Biopsy-Free Prediction of Pathologic Type of Primary Nephrotic Syndrome Using a Machine Learning Algorithm
Authors: Li Cuifang , Yao Zhijiang , Zhu Minfeng , Lu Ben , Xu Hui
Published: December 2017

Background/Aims: Renal biopsy is the gold standard to determine the pathologic type of primary nephrotic syndrome, which is critical for diagnosis, choice of treatment and evaluation of prognosis. However, in some cases, renal biopsy cannot be performed. Methods: To explore the possibility of predicting the histology type of primary nephrotic syndrome without the need for biopsy, we trained and validated a machine learning algorithm using data from 222 patients with biopsy-confirmed primary nephrotic syndrome treated at our hospital between May 2008 and January 2016. The model was then tested prospectively on another sample of 63 patients with biopsy-confirmed primary nephrotic syndrome. Results: Overall accuracy of prediction from the retrospective set of 222 patients was 62.2% across all types of nephrotic syndrome. The accuracy of model prediction for the prospectively collected dataset of 63 patients was 61.9%. The algorithm identified 17 of 33 variables as contributing strongly to type of renal pathology. Conclusion: To our knowledge, this is the first such application of machine learning to predict the pathologic type of primary nephrotic syndrome, which may be clinically useful by itself as well as helpful for guiding future efforts at machine learning-based prediction in other disease contexts.
Proteomic Analysis Reveals a New Benefit of Periodic Mechanical Stress on Chondrocytes
Authors: Li Zeng , Wang Zhen , Xu Shun , Liang Wenwei , Fan Weimin
Published: December 2017

Background/Aims: In recent years, a variety of studies have been performed to investigate the cellular responses of periodic mechanical stress. In our previous studies, we found that periodic mechanical stress can promote proliferation and matrix synthesis through the integrin beta 1-mediated ERK1/2 pathway, and we used proteomic analysis to detect quantitative changes in chondrocytes under periodic mechanical stress. Despite these results, the effects and mechanisms of periodic mechanical stress are still not fully understood, so in this study we extended our study using phosphoproteomic techniques. Methods: We used phosphoproteomic techniques to detect phosphorylation changes in chondrocytes under periodic mechanical stress and combined the results with the quantitative proteomic data to further explore the underlying mechanisms. Data were obtained by phosphorylation inhibition, quantitative real-time PCR (qPCR) analysis, western blot analysis and immunofluorescence assay. Results: From phosphoproteomic analysis, a total of 1073 phosphorylated proteins and 2054 phosphopeptides were identified. The number of significant differentially expressed proteins and phosphopeptides was 97 and 108, respectively (ratio >1.20 or <0.83 at p<0.05). Periodic mechanical stress increased glycogen synthase kinase 3-beta (GSK3-beta) phosphorylation at Y216, promoted the phosphorylation of beta-catenin, decreased beta-catenin levels and suppressed the expression of type I collagen. In contrast, inhibition of GSK3-beta by TWS119, which specifically inhibits the phosphorylation of Y216, suppressed the phosphorylation of beta-catenin, which resulted in the accumulation of beta-catenin and an increase in the expression of type I collagen. Conclusions: We successfully constructed differentially expressed phosphoproteomic profiles of rat chondrocytes under periodic mechanical stress, and discovered a potential new therapeutic benefit in which periodic mechanical stress suppressed the formation of type I collagen in the matrix of chondrocytes via phosphorylation of GSK3-beta and beta-catenin.
DNA Methyltransferase 1–Dependent DNA Hypermethylation Constrains Arteriogenesis by Augmenting Shear Stress Set Point
Authors: Heuslein Joshua L. , Gorick Catherine M. , Song Ji , Price Richard J.
Published: December 2017

Background

Arteriogenesis is initiated by increased shear stress and is thought to continue until shear stress is returned to its original “set point.” However, the molecular mechanism(s) through which shear stress set point is established by endothelial cells (
EC
s) are largely unstudied. Here, we tested the hypothesis that
DNA
methyltransferase 1 (
DNMT
1)–dependent
EC DNA
methylation affects arteriogenic capacity via adjustments to shear stress set point.

Methods and Results

In femoral artery ligation–operated C57
BL
/6 mice, collateral artery segments exposed to increased shear stress without a change in flow direction (ie, nonreversed flow) exhibited global
DNA
hypermethylation (increased 5‐methylcytosine staining intensity) and constrained arteriogenesis (30% less diameter growth) when compared with segments exposed to both an increase in shear stress and reversed‐flow direction. In vitro,
EC
s exposed to a flow waveform biomimetic of nonreversed collateral segments in vivo exhibited a 40% increase in
DNMT
1 expression, genome‐wide hypermethylation of gene promoters, and a
DNMT
1‐dependent 60% reduction in proarteriogenic monocyte adhesion compared with
EC
s exposed to a biomimetic reversed‐flow waveform. These results led us to test whether
DNMT
1 regulates arteriogenic capacity in vivo. In femoral artery ligation–operated mice,
DNMT
1 inhibition rescued arteriogenic capacity and returned shear stress back to its original set point in nonreversed collateral segments.

Conclusions

Increased shear stress without a change in flow direction initiates arteriogenic growth; however, it also elicits
DNMT
1‐dependent
EC DNA
hypermethylation. In turn, this diminishes mechanosensing, augments shear stress set point, and constrains the ultimate arteriogenic capacity of the vessel. This epigenetic effect could impact both endogenous collateralization and treatment of arterial occlusive diseases.
Can We Hear the Spoken Words of Gregory of Nazianzus?
Authors: Daunton-Fear Andrew
Published: December 2017

St. Gregory of Nazianzus, of great repute in the Orthodox Church as a theologian, was also an outstanding preacher whose style was honed by some of the greatest teachers of rhetoric of his day. We have scripts of forty-four of his homilies (orations), issued to posterity from his retirement. Their often complex style and thought has led some scholars to deduce that he heavily reworked them and to question whether we can any longer hear what he actually said. Yet his powerful employment of rhetorical figures, particularly in his festal orations, but also elsewhere, and his frequent use of direct speech to individuals, groups, or his whole audience, suggest that here at least we can hear his actual spoken words.
A Byzantine Logician’s “Image” within the Second Iconoclastic Controversy. Nikephoros of Constantinople
Authors: Goncharko Oksana Yu. , Goncharko Dmitry N.
Published: December 2017

The article is devoted to the study of the single example of logical education in Byzantium – the famous two pages from the hagiography of Patriarch Nikephoros (†829) containing the list of chapter headings copied by Ignatios the Diacon from an elementary textbook of logic. It is argued that, during the disputes of the second iconoclastic controversy, Patriarch Nikephoros implemented almost all the elements of logical knowledge listed by Ignatios. The article represents a short overview connecting the standard logical topics from the 8th- and 9th-century education program with the variety of arguments and techniques used by Nikephoros in the Major Apology and the Antirrhetics. The authors try to reconstruct the “image” of Patriarch Nikephoros as a logician and to describe the logical educational standard of his epoch.
The Prevalence of Iron Deficiency Anemia and its Associated Risk Factors Among a Sample of Female University Students in Tabuk, Saudi Arabia
Authors: Alzaheb Riyadh A , Al-Amer Osama
Published: December 2017

Background:

Prior data on iron deficiency anemia’s (IDA) prevalence and associated risk factors among female university students are scarce in the Saudi Arabian context. This study therefore recruited a sample of female students at the University of Tabuk, Saudi Arabia, to investigate IDA prevalence and risk factors and fill the identified research gap.

Methods:

A cross-sectional study of 200 apparently healthy female students aged between 19 and 25 years was performed between February and June 2016. Data on the participants’ sociodemographics, diet, health, anthropometry, and hematological and biochemical iron status indices were gathered. A logistic regression analysis then revealed the IDA risk factors.

Results:

The IDA prevalence was 12.5%. The factors associated via logistic regression with an elevated anemia risk were inadequate iron and vitamin C intakes, infrequent (≤2 times per week) consumption of red meat, frequent (≥2 times per week) tea consumption, and a past personal history of IDA.

Conclusions:

The findings suggest that focused education and awareness strategies are needed to improve nutritional habits by encouraging the consumption of rich dietary iron sources and by raising awareness of the food and drinks which facilitate or hinder the bioavailability of iron.
A service evaluation of outcomes in two in-patient recovery units
Authors: Macpherson Rob , Calciu Claudia , Foy Chris , Humby Kim , Lozynskyj Dave , Garton Charles , Steer Hannah , Elliott Helen
Published: December 2017

Aims and method

To evaluate outcomes for patients during their admission or in the first year of treatment in two in-patient recovery units. Changes in health and social functioning, service use and need (rated by patients and staff) were evaluated.

Results

In 43 patients treated, there was a large (30%) increase in patients discharged to their own tenancies, rather than supported accommodation. There was minimal change in Health of the Nation Outcome Scales (HoNOS) scores in the course of the admission but staff- and patient-rated unmet needs reduced and met needs increased. Needs changed mainly in domains relating to social functioning. Reductions in risk to self and others were rated by staff but not patients. There were no cases of patients being readmitted to acute hospital during the study period.

Clinical implications

Although these results offer some support to the treatment approach described in these in-patient recovery units, further research in larger samples is needed to identify how these services can best be deployed to help individuals with severe mental illness and complex needs.
New models of care: a liaison psychiatry service for medically unexplained symptoms and frequent attenders in primary care
Authors: Bestall Janine , Siddiqi Najma , Heywood-Everett Suzanne , Freeman Charlotte , Carder Paul , James Mick , Kennedy Brendan , Moulson Angela , House Allan
Published: December 2017

Aims and method

This paper describes the process of setting up and the early results from a new liaison psychiatry service in primary care for people identified as frequent general practice attenders with long-term conditions or medically unexplained symptoms. Using a rapid evidence synthesis, we identified existing service models, mechanisms to identify and refer patients, and outcomes for the service. Considering this evidence, with local contingencies we defined options and resources. We agreed a model to set up a service in three diverse general practices. An evaluation explored the feasibility of the service and of collecting data for clinical, service and economic outcomes.

Results

High levels of patient and staff satisfaction, and reductions in the utilisation of primary and secondary healthcare, with associated cost savings are reported.

Clinical implications

A multidisciplinary liaison psychiatry service integrated in primary care is feasible and may be evaluated using routinely collected data.
Implementation of a novel primary care pathway for patients with severe and enduring mental illness
Authors: Röhricht Frank , Waddon Gopal Krishan , Binfield Paul , England Rhiannon , Fradgley Richard , Hertel Lise , James Paul , Littlejohns Judith , Maher David , Oppong Matthew
Published: December 2017

Aims and method

New collaborative care models with an emphasis on primary care are required for long-term management of patients with severe and enduring mental illness (SMI). We conducted a descriptive evaluation of clinical outcomes of the first 3 years of a novel enhanced primary care (EPC) service. Data from 2818 patients and staff survey results were analysed.

Results

2310 patients were discharged to EPC (508 not assessed as clinically suitable or patients/general practitioners declined the transfer); mean length of stay with secondary care service of the cohort was 9.8 years (range 0–24). 717 patients (31%) have been discharged to primary care only out of the EPC services and 233 patients (10%) have been transferred back to secondary care. Patient and staff satisfaction with the new EPC model was high. No severe untoward incidents were recorded.

Clinical implications

The data suggest that EPC can be safely provided for a significant proportion of patients with SMI, who traditionally received long-term secondary care support. The novel EPC model can be utilised as a template for the provision of cost-effective, recovery-oriented and non-stigmatising care in the community.
Mental health law across the UK
Authors: Zigmond Tony
Published: December 2017

The criteria governing medical treatment without consent in the three legal jurisdictions of the UK – England and Wales, Scotland and Northern Ireland – is discussed.
Delayed Post Caudal Catheter Placement Pseudomeningocele: A Case Report
Authors: Bradford Victoria A. , Falcon Ricardo J. , Petersen Timothy R. , Soneru Codruta N.
Published: December 2017

We present a rare case of a 7-month-old infant who developed a pseudomeningocele 16 days after an uneventful caudal catheter placement. The patient did not exhibit neurological deficits or signs of infection, and the mass increased in size with Valsalva maneuver. Pseudomeningocele, an abnormal collection of cerebrospinal fluid around an opening in the dura mater, can be iatrogenic or traumatic. Regional anesthesia is rarely the cause. Recognizing diagnostic features such as the lack of infectious signs and mass compressibility can prevent misdiagnosis and inappropriate invasive treatment.
Robert Michels: Κριτική της Σοσιαλδημοκρατίας. Οι καταβολές της κοινωνιολογίας των κομμάτων
Authors: Auernheimer Gustav
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Η μισθωτή εργασία ως προνομιακό πεδίο για τη συγκρότηση κοινωνικών κινημάτων στο Μεσοπόλεμο
Authors: Αβδελά Έφη
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Phylogenetic relationships in Seslerieae (Poaceae) including resurrection of Psilathera and Sesleriella, two monotypic genera endemic to the Alps
Authors: Kuzmanović Nevena , Lakušić Dmitar , Frajman Božo , Alegro Antun , Schönswetter Peter
Published: December 2017

Sesleria (Poaceae) is a species‐rich, taxonomically difficult genus due to high morpho‐anatomical variability and weak differentiation of many species. It is distributed throughout western Eurasia and North Africa with highest taxonomic diversity on the Balkan Peninsula. Of the more than 40 species only two are diploid, all others are tetra‐ to dodecaploid, and many species comprise several ploidy cytotypes. We sequenced the plastid trnL‐ndhF region and produced amplified fragment length polymorphisms (AFLPs) from a comprehensive, ploidy‐cytotyped sampling including 292 populations, and produced nuclear ribosomal internal transcribed spacer (ITS) sequences for a subsample. Our first aim was to determine the relationships among Sesleria and putatively closely related genera. Further, we explored whether diploid S. sphaerocephala and S. ovata should be treated as separate genera Sesleriella and Psilathera as proposed previously, or rather included in Sesleria, following most recent Floras. Finally, we tested previous hypotheses of infrageneric classifications. In the ITS phylogeny tetra‐ to dodecaploid Sesleria s.str. grouped with diploid S. ovata whereas diploid S. sphaerocephala was more distantly related. In contrast, in the plastid phylogeny Sesleria s.str. grouped with S. sphaerocephala, whereas S. ovata was sister to Echinaria. This suggests an allopolyploid origin of Sesleria s.str. with S. sphaerocephala acting as maternal and S. ovata as paternal species. The lack of monophyly of Sesleria s.l. thus supports the recognition of S. ovata and S. sphaerocephala as separate genera Psilathera and Sesleriella. Their segregation, which is also supported by morphology, increases the number of angiosperm genera endemic to the European Alps from three to five. In congruence with the plastid sequences, AFLPs resolved the traditionally recognized sections (sect. Argenteae, sect. Sesleria) as non‐overlapping clusters and identified S. vaginalis as a probably recently evolved intersectional hybrid. Within the two sections, several informal species groups could be recognized, which show limited congruence with those proposed in the most comprehensive taxonomic treatment of the genus. From an evolutionary point of view it is obvious that ancient as well as recent hybridization coupled with polyploidisation have played a crucial role in diversification within Sesleria.
Policy of law creation in the regions of Russia: comparative analysis
Authors: Гуляков Александр , Gulyakov Aleksandr , Дунаев Андрей , Dunaev Andrey
Published: December 2017

The article is a specialized review legislative practice of subjects of the Russian Federation aimed at formation of the idea of one of the most important component regional legal life - legal policy. The article reveals fundamentals regional legal policy: principles, goals, means, forms of realization. The key factors defining problems of law-making policy at regional level, methods of their decision are considered by various subjects of the Russian Federation. The essential attention is paid to the comparative analysis of the regional legislation defining a vector of development of legal policy. The autors reveal strengths and weaknesses of activity of the regional authorities directed on improvement of legislative process.
On the Level of Competence of the Teacher to Ensure the Effectiveness and Quality of Teaching Geography
Authors: Абатурова Валентина , Abaturova Valentina , Болотина Татьяна , Bolotina Tatyana , Крылова О. , Krylova O.
Published: December 2017

In the article on the basis of the professional standard “Teacher” the types and groups of necessary competences of the geography teacher for the eff ective organization of teaching the subject are given. The mechanisms for assessing the competences of the teacher of geography with examples of tasks are described.
The legal status of a security officer when carrying out quickly-search actions
Authors: Луговик Виктор , Lugovik Victor , Лугович Сергей , Lugovich Sergey
Published: December 2017

The monograph is devoted to the study of the legal position of a security officer when carrying out quickly-search actions and to ensure the legality of its activities.
The work reveals the concept and content of the legal status of a security officer, analyzes the Russian and foreign legislation, regulating the activities of the employees of operational units, particular attention is paid to the prosecutorial supervision of security officer.
The work is designed for employees of operational units, cadets, students, adjuncts and lecturers of specialized schools and for students, teachers and researchers of law schools and scientific institutions.
Ethnohermeneutics Russian fairy tales
Authors: Пименова Марина , Pimenova Marina
Published: December 2017

The monograph describes Russian folk tales from an unusual point of view. It deals with the mentality of the Russian people, language categorization, conceptualization, specifics of the manifestation of the national mentality. The monograph is intended for philologists, culturologists, psychologists and a wide range of readers interested in the problems of mentality, language, psychology, astronomy, culture and the history of the people.
Emporion : un exceptionnel gros module postarchaïque à la tête de Silène / chouette dans carré creux
Authors: Ripolles Pere , Chevillon Jean-Albert
Published: December 2017

Parmi les monnaies « lourdes » attribuables à l’Emporion grecque pour sa période archaïque nous avons publié, en 2013, un spécimen à la tête de Silène de face avec un carré creux au revers. Cet exemplaire fut mis, en tenant compte de sa valeur pondérale importante, en équivalence avec les autres nominaux recensés pour la phase A de ce monnayage. Or, suite à notre récente mise en avant d’un groupe inédit d’oboles postarchaïques empuritaines avec au revers un carré creux contenant une chouette et des lettres autour, nous proposons de relier dans le temps ces deux émissions. Nous nous appuierons pour cela, entre autres, sur la présence désormais avérée dans le carré creux de notre exemplaire d’une chouette au style et aux dimensions équivalentes, ainsi que sur une métrologie de ces deux groupes qui se complète parfaitement. Ce spécimen devient le premier représentant d’un nominal « lourd » pour cette phase..
Librae, staterae y aequipondia de Segobriga. Instrumentos de pesar hallados en la ciudad y su entorno
Authors: Cebrián Fernández Rosario , Hortelano Uceda Ignacio
Published: December 2017

Se analiza en este artículo un conjunto de 25 piezas vinculadas a instrumentos de pesar procedentes de la ciudad de Segobriga y su entorno. Se trata principalmente de contrapesos de staterae, uno de ellos con indicación epigráfica de su peso en libras, y varias librae de pequeño tamaño. El contexto arqueológico de los hallazgos ofrece una cronología que abarca desde el primer tercio del siglo I a. C. hasta el III d. C.
A Homofobia como Signo Ideológico dos Crimes de Ódio: Uma Análise da Argumentação Discursiva sobre os Direitos LGBT’S
Authors: Melo Miguel Ângelo Silva de , Silva Isaac De Oliveira Magalhães e , Dias Karollyne Magalhães , Gomes Filho Antoniel Dos Santos
Published: December 2017

A justificativa da presente investigação se dá, por um lado, pela constatação de que nunca se teve um momento tão propício para se analisar os discursos homofóbicos proferidos por oradores que buscam propagar o ódio, intencionando assim, adesão aos seus discursos argumentativos por auditórios específicos. Por outro lado, encontramos a movimentação civil organizada LGBT que vêm na contramão destes discursos, promovendo a desconstrução da retórica-argumentativa do preconceito, da exclusão e da abjeção, trazendo perspectivas anti-homofóbicas que se põem na transversalidade dos discursos do ódio, e respectivamente, buscam a criminalização dos crimes de ódio motivados pela orientação sexual e pela identidade de gênero da(s) vítima(s). A metodologia utilizada neste artigo é eminentemente, uma revisão bibliográfica de cunho sociológico com ênfase na produção da linguagem por meio de discursos argumentativos em defesa da dignidade da pessoa humana. Os achados indicam que a mobilização dos movimentos sociais foi fundamental para a definição de crimes de ódio enquanto todo e qualquer crime motivado pelo preconceito contra um determinado grupo social do qual a vítima faz parte direta ou indiretamente.
Tecnologia Assistiva para uma Escola Inclusiva: Desafios e Perspectivas
Authors: Alencar Simone Dos Santos , França Aurenia Pereira de
Published: December 2017

A abordagem apresentada neste artigo tem como temática a Tecnologia Assistiva para Escola Inclusiva, a qual seu maior desafio é ofertar à acessibilidade para as pessoas com deficiência, garantindo igualdade de condições com os demais. Objetivando analisar a contribuição da tecnologia assistiva na inclusão de crianças em ambiente escolar. Este estudo torna-se propício para as atividades das crianças, com algum tipo de deficiência. A metodologia utilizada para desenvolver o presente estudo é de ordem bibliográfica e qualitativa. Os teóricos que fundamentam essa pesquisa são: Miranda (2006), Galvão (2004), Kleiman (2007), entre outras fontes. Observou-se que é de grande relevância o processo de apropriação e uso da tecnologia assistiva. A fim de melhorar a qualidade de vida de todas as pessoas,  para que sejam vistas de forma inclusiva diante da sociedade. Palavras-chave:
Análise Parasitológica de contaminantes de origem fecal encontrados em uma Creche do interior da Bahia
Authors: Almeida Naysnan Rocha Brito , Carvalho Alana Soares , Moreno Camila Amaral
Published: December 2017

O parasitismo intestinal ainda é considerado um grave problema de saúde pública, estima-se que mais de 2 bilhões de pessoas estejam infectadas por parasitas intestinais, dentre eles destaca-se: Ascaris lumbricoides, Trichuris trichiura, Necator americanus e Ancylostoma duodenale. Dentre os grupos populacionais, as crianças são as mais acometidas pelas parasitoses. A maior concentração dos casos de parasitismo ocorre em áreas onde o saneamento básico é inexistente ou insuficiente, características de países em desenvolvimento com inadequada infraestrutura sanitária e ambiental. Este trabalho tem por objetivo identificar e avaliar o perfil epidemiológico de contaminantes de origem fecal, presentes em fômites de uma creche no interior da Bahia, em um distrito do município de Planalto. Trata-se de um estudo, descritivo exploratório com abordagem qualitativa. O local escolhido para realização do estudo foi uma creche municipal. O trabalho foi realizado a partir de coleta de amostras presentes no interior da creche, com base no método de Graham. Os dados foram organizados e tabulados com auxílio do programa Microsoft Excel 2010. Os resultados apontaram 87,5% de amostras positivas e 12,5% negativas. Conclui-se que a incidência de parasitas em creches é um problema de saúde pública de alta magnitude que merece atenção especial.
Determinação do Teor de Captopril 25mg por Espectrofotometria de Absorção Molecular – UV, comercializado em Farmácias de Manipulação de Vitória da Conquista/BA
Authors: Silva Rafael Queiroz , Oliveira Caio Matheus Da Rocha Couqueiro Monteiro de
Published: December 2017

Sendo indicado para o tratamento da hipertensão, insuficiência cardíaca, infarto do miocárdio e nefropatia diabética, o captopril é uma droga anti-hipertensiva e vasodilatadora que pode ser encontrada nas farmácias do país, na forma de cápsulas, de 12,5mg, 25mg ou 50mg, doses que variam especificamente pela variação da quantidade do captopril existente em cada fórmula. Dentro dessa ótica, a finalidade do presente trabalho foi analisar o controle de qualidade, bem como ponderar a função do anti-hipertensivo em questão nas farmácias magistrais, com base na avaliação do perfil de doseamento do fármaco em questão. Metodologia: foi realizada análise do captopril 25mg, que foram denominados de A, B e C, através da espectrofotometria de absorção molecular UV (ultravioleta). O fármaco em apreço foi obtido por meio de farmácias magistrais de Vitória da Conquista/BA. Resultado: feita a pesquisa do captopril 25mg, obtemos o teor de 92,76% para o fármaco A, 112,98% para o B e 105,88% para o C, pelo que se conclui que o fármaco em questão não se encontra em padrões adequados de concentração de acordo com a Farmacopeia Brasileira (Volume 2, 5ª Edição), tendo em vista que os valores obtidos ficaram fora do mínimo/máximo permitidos, 97,5% e 102,0%, respectivamente, em relação à substância analisada.
Perfil dos Pacientes portadores de Lúpus Eritematoso Sistêmico atendidos pelo Componente Especializado da Assistência Farmacêutica em uma Regional de Saúde
Authors: Prado Diane De Matos , Amaral Bruno Andrade , Duarte Stênio Fernando Pimentel , Vale Ademir Evangelista do , Silva Matheus Lemos , Rocha Arlene Ribeiro , Sousa Vitória Magalhães
Published: December 2017

O Lúpus Eritematoso Sistêmico (LES) é uma doença de caráter autoimune e crônico inflamatório, que possui etiologia multissistêmica e afeta principalmente as mulheres, em diversos órgãos, podendo estar ligada a fatores ambientais, hormonais e infecciosos. A doença é diagnosticada, por meio do auxílio de exames laboratoriais, a anamnese eficaz e correlação com critérios diagnósticos específicos, a fim de se iniciar o tratamento. Este artigo tem como objetivo descrever o perfil sociodemográfico e clínico dos pacientes portadores de LES atendidos pelo Componente Especializado da Assistência Farmacêutica em uma Regional de Saúde, observando o perfil sociodemográfico da população estudada, os exames laboratoriais que favorecem a observação da efetividade e segurança dos tratamentos instituídos e observação da correlação com os fatores de pré-disposição. Foi realizado estudo no NRS entre Agosto e Setembro de 2017, por meio de coleta de dados em prontuários, através do Kobocollect, sendo analisados posteriormente no software aplicativo SPSS. A maioria dos pacientes era do sexo feminino (95,5%), pardos (58%), faixa etária média de 41,08 anos, procedentes de Vitória da Conquista-BA. As alterações mais frequentes observadas foram: distúrbio hematológico 21% (n=58), hepático 19% (n=35) e renal 16% (n=16), sendo que os medicamentos mais frequentemente associados a esses distúrbios, foram a Azatioprina e Hidroxicloroquina. Na população em questão, os pacientes apresentaram um perfil condizente com o esperado pela literatura, sendo na sua maioria do sexo feminino, pardos, adultos jovens, com IMC normal, com presença de anormalidades hematológicas, hepáticas e renais.
Violência Contra Idosos: Associação Entre o Gênero dos Agressores e o Tipo de Violência
Authors: Silva Adriene Reis S , Sampaio Lucas Silveira , Reis Luciana Araújo dos , Sampaio Talita Santos Oliveira
Published: December 2017

Este estudo tem como objetivo analisar a associação entre o gênero dos agressores dos idosos com o tipo de violência. Trata-se de uma pesquisa quantitativa analítica-descritiva com delineamento transversal, que utilizou dados da pesquisa “Violência Contra Idosos: Perfil das Violências Segundo Registro das Instâncias de Referência”. Foram utilizadas 55 notificações de violência contra idosos registradas no SINAN, entre 2012 a 2015 no município de Vitória da Conquista – BA. Segundo os resultados, os cônjuges são os principais agressores de idosos (27,3%), sendo que o sexo masculino foi o mais prevalente nas agressões (74,5%). O tipo de violência mais relatado foi a psicológica (83,6%), seguida da física (49,1%). Observou-se que a variável sexo está associada com todas as violências (psicológica, sexual, financeira, física e negligência). Diante disso, salienta-se a necessidade de elaboração de ações que visem à prevenção desse abuso e melhorias na assistência tanto a vítima como o agressor.
The effects of model based missing data methods on guessing parameter in case of ignorable missing data
Authors: Koçak Duygu
Published: December 2017

The present study aims to investigate the effects of model based missing data methods on guessing parameter in case of ignorable missing data. For this purpose, data based on Item Response Theory with 3 parameters logistic model were created in sample sizes of 500, 1000 and 3000; and then, missing values at random and missing values at completely random were created in ratios of 2.00%, 5.00% and 10.00%. These missing values were completed using expectation'maximization (EM) algorithm and multiple imputation methods. It was concluded that the performance of EM algorithm and multiple imputation methods was efficient depending on the rate of missing values on the data sets with missing values completely at random. When the missing value rate was 2.00%, both methods performed well in all sample sizes; however, they moved away from reference point as the number of missing values increased. On the other hand, it was also found that when the sample size was 3000, the cuts were closer to reference point even when the number of missing values was high. As for missing values at random mechanism, it was observed that both methods performed efficiently on guessing parameter when the number of missing values was low. Yet, this performance deteriorated considerably as the number of missing values increased. Both EM algorithm and multiple imputation methods did not perform effectively on guessing parameter in missing values at random mechanism.
Effects of adapted physical activity applied on intellectual disability students toward level of emotional adjustment, self-managingand the socialization: Parent and teacher interactive research
Authors: Güvendi Burcu , İlhan Ekrem Levent
Published: December 2017

The purpose of the research is to investigate the effects of adapted physical activity applied on intellectual disability students toward level of emotional adjustment, self-managing and the socialization. The study was designed as pretest-posttest experimental model. Intellectual disab 12 students from 5th and 6th grade who continue their education at the public school in Esenyurt district of İstanbul in 2015-2016 academic year spring semester. Adapted physical activity program was applied the students for 2 days 1 hour per week for 12 week. Hacettepe Emotional Adjustment Scale, Self-Managing and Socialization which of subheading AAMD Adaptive Behavior Scala were used to collect data. Pretest-posttest descriptive analysis was and Wilcoxon Test was used in dependent comparisons. The results showed that decline in students’ pretest-posttest mean scores of neurotic problems and behavior problems was seen according to mothers and the school counselor of the students. An increase was observed in pretest-posttest mean scores of self-managing and socialization on behalf of the posttest. According to data from mother and school counselor,  significant differences were determined between pretest-posttest on behalf of the posttest in neurotic and behavior problems which of subheading Emotional Adjustment Scale, self-managing and socialization which of subheading AAMD Adaptive Behavior Scala. Adapted physical activity applied on intellectual disability students affected positively level of emotional adjustment; self-managing and the socialization were seen. Additionally students’ socialization scores increased and emotional adjustment problems decreased were observed.
Editorial
Authors: Amaruli Rabith Jihan
Published: December 2017

Aspek kebudayaan telah lama tidak menjadi perhatian para pemangku kebijakan. Orientasi pembangunan nasional yang melulu pada pembangunan fisik (sarana dan prasarana), dan karenanya pendekatan yang digunakan pun sangat materialistis, telah menempatkan kebudayaan sebagai “anak tiri” pembangunan. Beberapa peristiwa politik nasional yang berkembang, mau tidak mau memaksa kita untuk kembali melihat kebudayaan dengan segala aspeknya, termasuk di dalamnya adalah penciptaan identitas kelompok yang semakin menguat. Ketika dahulu orang Indonesia berupaya untuk meleburkan diri dengan kelompok-kelompok arus utama (baik politik mapun budaya), saat ini orang menjadi semakin butuh untuk memiliki identitas yang berbeda dengan yang lain. Ketika sebelumnya menjadi liyan (orang lain) adalah sesuatu yang “tabu” dan senantiasa dihindari, saat ini orang Indonesia justru berusaha keras untuk menjadi apa yang disebut dengan liyan itu
Bersekolah di Tanah Pengasingan: Boven Digul, 1927-1943
Authors: Budi Langgeng Sulistyo
Published: December 2017

Artikel ini membahas tentang penyelenggaraan pendidikan di kamp pengasingan Boven Digul pada periode antara tahun 1927-1943. Beberapa persoalan yang akan dibahas dalam artikel ini adalah mengenai jenis sekolah yang didirikan di Boven Digul, para pelaku dalam proses belajar-mengajar di sekolah-sekolah itu, dan dampak dari keberadaan sekolah-sekolah itu baik bagi para penghuni kamp maupun masyarakat Boven Digul. Metode Sejarah dengan pendekatan sosiologis digunakan dalam penelitian ini, dengan sumber berupa arsip dan wawancara. Kamp pengasingan Boven Digul didirikan oleh pemerintah Belanda dan dioperasikan mulai dari 1927 sampai dengan 1943. Tahanan politik yang diasingkan di kamp ini pada awalnya adalah mereka yang terlibat dalam pemberontakan komunis di Banten (Jawa Barat) dan Sumatera Barat pada 1926-1927. Namun, pada tahun-tahun berikutnya para tokoh nasionalis juga menjadi penghuni kamp itu. Para tahanan diizinkan untuk membawa keluarganya. Untuk memenuhi kebutuhan pendidikan di kamp pengasingan, pemerintah kolonial Belanda pada 1927 mendirikan Standaardschool, dan kemudian menjadi Standaardschool met Nederlandsch. Kelompok tahanan naturalisten juga diizinkan untuk mendirikan sekolah bernama Malay English School (MES), yang kemudian menjadi sekolah “tiga keluarga”, diadakan di rumah-rumah para tahanan. Pada 1940-an, murid-murid dari sekolah “tiga keluarga” dimasukkan ke Standaardschool, sebab banyak guru yang beralih profesi. Mereka mencari nafkah lain ketika suplai bantuan menurun akibat blokade Jepang terhadap perairan di sekitar Papua. Baik Standaardschool, MES maupun sekolah “tiga keluarga” hanya diperuntukkan bagi keluarga para tahanan politik. Oleh karena itu, keberadaan sekolah-sekolah itu tidak memberi pengaruh pada masyarakat asli di sekitar kamp pengasingan.
Di Bawah Bayang-Bayang Kota: Penataan Daerah di Provinsi Banten dari Zaman Kolonial sampai Zaman Reformasi
Authors: Wijono Radjimo Sastro
Published: December 2017

Artikel ini membahas reformasi wilayah yang berlangsung di provinsi termuda di Indonesia yaitu Banten sejak zaman penjajahan Belanda sampai masa reformasi. Reformasi wilayah yang terjadi di daerah ini sangat menarik untuk dipelajari. Situasi politik-ekonomi merupakan faktor utama terjadinya reformasi wilayah di Banten. Dengan menggunakan metode sejarah, perubahan pengaturan wilayah Banten diketahui telah terjadi beberapa kali sejak masa penguasa tradisional (kesultanan) yang dilumpuhkan oleh pemerintah kolonial pada abad ke-19 hingga masa reformasi. Pada masa kolonial, Gubernur Jenderal Daendles mereformasi wilayah Banten menjadi tiga kabupaten yaitu Banten Hulu, Banten Hilir, dan Anyer. Sementara itu, pada masa kolonial Inggris wilayah Banten dibagi menjadi empat kabupaten yaitu Banten Lor, Banten Kulon, Banten Tengah, dan Banten Kidul. Perubahan kebijakan reformasi teritorial itu tentu saja membawa dampak dalam bidang politik, ekonomi, dan budaya. Regulasi penataan wilayah di Banten tidak hanya dipengaruhi oleh bayang-bayang situasi politik dan ekonomi dari Jakarta dan Bandung, tetapi juga berdasar pada aspek ekologis serta kepentingan umum masyarakat yang multikultur.