bluuebunny/crossref_metadata_2025 huggingface dataset:
Opsoclonus-myoclonus-ataxia syndrome as a complication of pembrolizumab treatment in an adult patient (a case report and literature review)
Authors: Rumiantseva K. A. , Polushin A. Yu. , Abduloeva N. Kh. , Skiba Ya. B. , Moiseenko V. M.
Published: April 2023

Background. Opsoclonus-myoclonus-ataxia syndrome (OMAS) in adults is an extremely rare condition, often leading to rapidly deteriorated neurological performance. The majority of published cases are considered as being of post-infectious, paraneoplastic or idiopathic origin. However, there have been reported few OMAS cases developed after administration of check-point inhibitors used in various oncological conditions. In the last decade, the widespread use of immunotherapy in oncology has led to rise in immune-related adverse events, including diverse neurological toxicities.

Objective: to evaluate an opportunity of OMAS-triggering PD-1 treatment.

Material and methods. We present the case report of a subacute OMAS onset in an elderly man after continuous administration of pembrolizumab as a first line treatment in bronchial squamous cell carcinoma. The study was conducted in accordance with the Helsinki Declaration. We also review the main OMAS clinical features, pathogenesis and immunological mechanisms in adults along with potential diagnostic and management strategies.

Results. The development of severe OMAS clinical picture during immunotherapy required the withdrawal of targeted treatment, which in combination with glucocorticoids led to a prominent regression of neurological deficit. After a thorough clinical investigation, infectious and organic factors were excluded, allowing for proposal of immunotherapy-triggered OMAS etiology in the patient.

Conclusion. Discontinuation of immunotherapy may be a justified means for OMAS clinical features in adult patients with verified oncological condition undergoing treatment with check-point inhibitors (considering all other etiologies are ruled out).
Mucocele of appendix unmasking appendiceal neoplasm
Authors: S. P. Gayathre , Kalaiselvi  , Rajeswaran Tharani
Published: April 2023

An appendiceal neoplasm is rare among all the gastrointestinal tumors. An appendiceal mucocele is a dilatation of the appendix due to a benign or malignant disease, which causes the obstruction of the appendix and consequent accumulation of mucus secretion. Mucinous malignancy of the appendix represents a low occurrence among appendiceal neoplasms. The preoperative diagnosis is difficult due to non-specific clinical manifestations of the disease. Preoperative investigations may be inconclusive for diagnosis at times. Management is based on the size and grade of the tumor. We had two female patients who presented with poorly defined symptoms in whom, radiological evidences showed appendiceal dilatation. Both the patients when proceeded with laparotomy, had no peritoneal spillage, and were subjected to right hemicolectomy. Based on the grade of the tumor, adjuvant management was planned. Both the patients had favorable outcomes following treatment.
Review of incisional hernias
Authors: Muñoz Delgado Gustavo E. , Lastra Santiago Maria A.
Published: April 2023

The 10 to 15% of patients get incisional hernias following any type of abdominal wall incision, with midline wounds carrying a larger risk (3 to 20%). Infection at the surgery site, obesity, smoking, malnutrition, and poor surgical technique are risk factors. Clinical signs include an abdominal bulge at or near a prior incision, which, in non-obese individuals, is frequently identified by palpating the split borders of the fascial defect. CT imaging is particularly useful for complicated ventral hernias, which are characterized by enormous size or considerable loss of dominance. For the purpose of detecting any contents within the hernia sac and deciding whether preoperative abdominal expansion is necessary to lower the risk of postoperative abdominal compartment syndrome, preoperative CT imaging is crucial. When clinically necessary, surgeons should think about making an incision outside the midline and employ the proper fascia closure procedures to lower the likelihood of an incisional hernia. Although the implantation of preventative mesh during the closure of abdominal incisions is being studied, routine usage is not advised owing to probable long-term problems. Incisional hernias can be treated surgically or expectantly, and the patient should be informed of both options.
Open abdomen: a comprehensive review
Authors: Muñoz Delgado Gustavo E. , Lastra Santiago Maria A.
Published: April 2023

When the abdominal viscera are visible due to a defect in the abdominal wall, which is usually caused intentionally or as a result of abdominal compartment syndrome, it is referred to as an open abdomen. As a protracted open abdomen can result in problems including fluid and protein losses, intestinal fistulization, and loss of abdominal dominance, the main goals of temporal abdominal closure techniques are to prevent fluid losses and loss of dominance. There are several techniques for short-term abdominal closure, each having advantages and disadvantages. These techniques include patch closure, silo closure, and negative pressure systems based on towels and sponges. After temporary abdominal closure, the patient is monitored in the critical care unit while any required adjustments are made to the abdominal dressings. Observational studies have shown that the Wittmann Patch has the highest average rate of primary fascial closure when compared to other operations. Yet, a temporary closure of this sort might not be adequate to stop fluid loss on its own. To monitor fluid loss, a negative pressure device (sponge- or towel-based) is advised. It can be used either on its own or in combination with other techniques for closing the temporal abdominal cavity. When the sign of an open abdomen has been removed, the abdomen is closed, ideally using a major fascial closure. If primary fascial closure cannot be achieved, functional closure may be accomplished using a biological mesh inlay method. While there is a good probability of developing a posterior hernia, this treatment adds new fascial tissue where the natural fascial limits are located. The fascia defect may be filled in with primary skin closure or skin grafts once a layer of granulation tissue has developed over the consolidated visceral mass if the space between the fascia's borders is too large for functional closure. Effective abdominal closure and the prevention of issues ultimately depend on proper management and supervision of temporary abdominal closure.
Higher prevalence of Listeriosis in Indian subcontinent, a food related menace
Authors: Chaudhry Sunil
Published: April 2023

The recent emergence of zoonotic disease from L. monocytogenes transmitted directly from infected animals and contaminated food products to humans is on rise in many developing countries. The calculated prevalence in south-east Asia is about 22.2 %. Orations on update are regularly conducted in some countries like Sri Lanka.
Review on nanoparticles for topical drug delivery
Authors: Shaikh Afroj A , Pawar Jaydeep B. , Anbhule Sachin J. , Kakade Vaibhav V.
Published: April 2023

An overview of the use of nanoparticles for topical drug delivery will be given in this review paper. Several experiments have been conducted in the past 25 years to remove some of the obstacles to skin delivery. These investigations have led to a rather modest progress in technology. A more recent method involved increasing the medication's concentration in the carrier to increase drug flow into and through the skin. Hydrophobic and hydrophilic medications can be delivered using nanoparticles, which have the ability to release drugs under regulated conditions over an extended period of time. It also increases patient compliance. Liposomes and solid lipid nanoparticles have the potential to be useful as topical medication delivery methods.
Effect of educational intervention on knowledge, attitude and practice about deworming and its association with anaemia among medical undergraduates in a medical college in dakshina Kannada
Authors: Suraksha P. R. , Shetty Robin , Kumar Sharath
Published: April 2023

The WHO considered soil-transmitted helminthiasis and schistosomiasis among neglected tropical diseases. It has affected more than a third of the world’s population. National Deworming Day (NDD) will be conducted yearly on February 10, followed by a mop-up day on February 15 in the country.According to WHO, across the world, about 24% of the population is infected with soil-transmitted helminthic infections.We used a validated questionnaire, and it included questions to evaluate the participant’sknowledge, attitude, and practice of deworming and anemia. Data was collected by giving 20 minutes to students to answer the questions. After that, a 30-minute lecture was given on anaemia and deworming using PPT. Students were again told to fill in the questionnaire immediately after the lecture. Pre-test and post-test scores were compared, and a chi-square test was used to test the association of knowledge, attitude, and practice. It was observed that knowledge, attitude, and practice among medical students increasedsignificantly after educational intervention.From the above study, we conclude that there is a significant impact on knowledge, attitude, andpractice. As a result, medical student training and healthcare professionals can effectively prevent worm infestation and thus anaemia in the population, which is a major burden in a developing country like India.
Characterization of arid soil quality: Physical and chemical parameters
Authors: ADYANOVA Altana , BULUKTAEV Aleksey , MUKABENOVA Raisa , MANDZHİEVA Saglara , RAJPUT Vishnu , SAYANOV Vasiliy , DJİMBEEV Nikita , SUSHKOVA Svetlana
Published: April 2023

Land degradation especially as a result of the rapid increase in demand and pressure in the population, have emerged as one of the most important problems. Degradation leads to the loss of biological and economic productivity due to the fact that the soil loses its functional properties, which are one of the most important elements of the terrestrial ecosystem. Combined with excessive biophysical and socio-economic damage in arid areas, land degradation causes irreversible consequences leading to desertification. Thus, land degradation is an environmental threat not only on a local or regional scale, but also on a continental or even global scale. The change in the state of soils as a result of anthropogenic impact and climatic changes determines the relevance of conducting a study of the soils of the Republic of Kalmykia. Endosalic Calcisols of sandy loam and sandy granulometric composition predominate in the structure of the soil cover of the southern part of the Caspian lowland, significant areas are occupied by sands. More than 70% of agricultural land is subject to wind erosion. Salt marshes are widely distributed.
Correlation analysis between inflammatory biomarkers and significant clinical phenotypes of chronic obstructive pulmonary disease
Authors: Orlova Ekaterina A. , Kuzmichev Bogdan Yu. , Orlov Mihail A. , Dorfman Inna P.
Published: April 2023

Introduction: Chronic obstructive pulmonary disease (COPD) is the leading cause of mortality. Using the evidence obtained about various clinical phenotypes of patients with the same disease allowed us to expand our understanding of the treatment of COPD. Nowadays the only option for solving the problem will be the definition of the clinical phenotype of COPD, and the receipt of expanded data on its correlation with respiratory and other significant biomarkers.
Materials and methods: We analyzed the correlations between FKN, CRP and TBA-active lipid peroxidation products in 373 patients with various COPD phenotypes and 60 healthy volunteers. Enzyme immunoassay was used to study the levels of inflammatory biomarkers.
Results: We have identified a statistically significant increase in the levels of inflammatory biomarkers in patients with COPD compared with the control. The FKN level in the group of patients with COPD was 1.3 ng/ml, which was higher (p<0.001) than in the control (FKN level of 0.3 ng/ml, p<0.001). The CRP level in patients with COPD was 27.8 mg/L, whereas in control the CRP level was 1.2 mg/L (p<0.001). The TBA-active lipid peroxidation products level in patients with COPD was 14.5 mmol/L, which was higher when compared to the control (p<0.001).
Discussion: The correlation analysis revealed very strong relationships between the levels of all the biomarkers studied. The highest values of the Kendall rank correlation coefficient (τ) were determined between the levels of all the inflammatory biomarkers in subgroups of patients with chronic bronchitis and mixed COPD phenotypes.
Conclusion: Detection of the COPD phenotype will help actively monitor the therapy of COPD exacerbations.
Graphical Abstract
The leading role of West Siberian Research and Geological Oil Exploration Institute in the development of the oil and gas potential of the West Siberian oil and gas province and the development of the country’s mineral resource base
Authors: Borodkin Vladimir N. , Komgort Marina V. , Nesterov (Jr.) Ivan I.
Published: April 2023

The history of creation is given, the complex of studies carried out by the Tyumen branch of Siberian Research Institute of Geology, Geophysics and Mineral Resources (SNIIGGiMS) in 1960–1964 and by West Siberian Research and Geological Prospecting Oil Institute (ZapSibNIGNI) in 1964–1996 is analyzed. The role of the Institute in the substantiation of oil and gas potential and developing the resource base of the West Siberian oil and gas province is shown. The scientific forecasts and developments of the Institute’s employees, which influenced the increase in the efficiency of geological exploration are presented. In preparing the article, previously unpublished documents from the archive of the Directorate of ZapSibNIGNI were used.
Problems of oil and gas potential realization in Bazhenov-Abalak play in Khanty-Mansi Autonomous Okrug – Yugra
Authors: Oksenoyd Elena E. , Isaev Valery I. , Kuzmenkov Stanislav G. , Novikov Maksim V. , Pecherin Timofey N.
Published: April 2023

This research aims to analyze problems related to resources, reserves and development of Bazhenov-Abalak oil and gas play and to find geological and technological solutions for bringing reserves into development commercially. This should stabilize oil production in Okrug on the level 210–215 million of tons. Geological, field and statistical data from V.I. Shpilman Research and Analytical Centre for the Rational Use of the Subsoil and Department of Subsurface Management & Natural Resources of Khanty-Mansi Autonomous Okrug – Yugra were retrospectively analyzed during this research.
Oil production from Bazhenov-Abalak play using conventional technologies is still sub economic. Running experimental areas and test ranges for industrial approval of development efficiency enhancement technologies for Bazhenov-Abalak play are created on producing fields. Unfortunately, accumulated experience ends up inside oil companies. Undoubtedly, single initiatives of oilmen will not solve a problem of development of huge resources in Bazhenov formation.
Ethno-cultural education in Kazakhstan, civic values and self-identity: Findings from a survey of undergraduates
Authors: Musakhanova Gulmira , Kalybekova Asma , Polatova Saule , Lekerova Gulsim , Kistaubaeva Dildar , Azizkhanova Didar  K.
Published: April 2023

The article discusses methods and ethno-pedagogical approachesinKazakh customs, traditions, rituals of creative work, pedagogical competitions where students get the opportunity to demonstrate theoretical knowledge, erudition, and originality of thinking. This is a comprehensive monitoring study to show the experiences of teaching students ethno-pedagogical and other pedagogical approaches for forming a civil and patriotic worldview among students and preserving ethno-cultural traditions.
Dialectical principles were used as the methodological basis of the study, making it possible to identify the main characteristics of the studied phenomena and processes in their interconnection for determining the trends in their formation and development. The results of the study shows the pedagogical potential of the ethno-cultural traditions of the Kazakh people is determined in its value -semantic aspect in the patriotic education of university students, taking into account modern socio-cultural conditions, traditions of the Kazakh people.
Keywords: patriotism, folk pedagogy, traditions, customs, patriotic education, university.
Attitude Toward Continue Medical Education and Professional Development of Emergency Medical Personnel – Cross-Sectional Study of Physicians and Nurses
Authors: Machitidze Manana , Goshadze Nona
Published: April 2023

Aim: Postgraduate education systems for medical professionals are constantly developing worldwide. The study aims to assess the knowledge and attitude toward the importance of continuing medical education and professional development of emergency medical personnel. Methodology and Design: Quantitative method study was conducted among Georgia "GEO Hospitals" regional clinics' emergency medicine department physicians and nurses. Study design cross-sectional study. Results: The attitude towards the knowledge and training of the clinic staff is heterogeneous, regardless of their qualification, and knowledge background. In addition to basic education, motivation is important for improving knowledge. In addition, the contact method is essential in training emergency management and life-saving. Conclusion:  Continuous medical staff education with effective methods is essential for improving the qualification of medical personnel. This leads to high-quality treatment, the clinic's reputation, reliability, and safe patient care.
Evaluation des Doses Variables du Miel Local de Apis Mellifera adansonii Latr. 1789 du Congo sur les Performances Zootechniques des Poulets de Chair standard
Authors: B.B. Mbanza –Mbanza , J.B. Bati , P.P. Adzona , J.R. Guembo , M.V. Ntsoumou , A.J. Saboukoulou , H. Banga Mboko
Published: April 2023

Le miel est un produit  qui renferme des propriétés nutritives susceptibles de stimuler les performances zootechniques des volailles. L’objectif de cette étude était de déterminer le taux d’incorporation optimal du miel dans les rations des poulets de chair. Un échantillon de 105 poussins de chair a été réparti en trois lots de 35 sujets  (témoin, traité 1 et traité 2).Chaque lot a été ensuite subdivisé en 5 répétitions   de 7 sujets  chacun. Les lots traités 1 et 2 ont reçu des doses du miel dans la ration alimentaire respectivement au démarrage 0,5% et 1%, en croissance 1% et 2% et en finition 1% et 4%. Le premier lot a servi de témoin. Les lots ont été comparés sur les variables de  la croissance pondérale.   Les résultats ont montré au cours de la phase de démarrage une amélioration significative (P < 0,05)  de  la consommation volontaire des aliments (30,5 g contre 34,8 g), du GMQ (22,7 g/jour contre 23,4 g/ jour), l’IC (1,3 contre 1,4) et le poids vif à 14 jours (359g contre 377 g). Par contre au cours de la phase de croissance, aucune différence significative n’a été notée dans la ration contenant 1% de miel. En revanche pendant la phase de finition, une amélioration significative a été observée sur tous les paramètres étudiés. Cette étude suggère l’utilisation du miel à la dose de 0,5% pendant les phases de démarrage et de croissance et à 1% au cours de la phase de finition.

 

Honey is a natural bee product containing nutritional properties able to stimulate the performance of poultry. The study aimed to determine the optimal rate of honey in the  diets of broiler. A sample of 105 chicks has been randomized and then divided into three groups of 35 chicks each (One control and two treated groups). Then each group was then divided in 5 replicates of 7 chicks. The treated groups received doses of honey at the starting 0.5% and 1%, in growing 1% and 2% finally in finishing stage 1% and 4% respectively. Groups were compared on the growth parameters. The results showed that during the starting stage, a significant improvement (P < 0.05) was observed on feed intake (30.5g vs 34.8g), DWG (22.7g per day vs 23.4g per day), feed efficiency (1.3 vs 1.4) and body live weight (359 vs 377g at 14 days). However, during the growing stage, no significant difference was observed on feed containing 1% of honey. Moreover, during the finishing stage, all the studied parameters were improved by honey at 1%. Therefore, the present study indicated the useful of honey at 0.5% during the starting and growing stages while 1% may be used during the finishing stage
John Jeffries Martin, A Beautiful Ending. The Apocalyptic Imagination and the Making of Modernity, Yale University Press, New Haven – London 2022, VIII + 324 PP., ISBN: 9780300247329
Authors: Cela Aldri
Published: April 2023

Review of:

John Jeffries Martin, A Beautiful Ending. The Apocalyptic Imagination and the Making of Modernity, Yale University Press, New Haven – London 2022, VIII + 324 PP., ISBN: 9780300247329.
Formulation, Development and Characterization of Sustained Release Formulation of Herbal Extracts
Authors: Kumar Servesh , Soni Vishal
Published: April 2023

Aim: The aim of the present investigation is to design of sustained release dosage form of different extracts that will help in releasing only small quantities of drug over a prolonged period of time. Material and Methods: The different ingredients for formulations are given as in Table 1 below. The measured quantities of drug, HPMC, MCC and NaHCO3 were mixed thoroughly using a mortar and pistil. The granules were punched into tablets using direct compression technique. The blank formulation (or) placebo (HPMC+ MCC+NaHCO3) and polyherbal formulation were also tested using FTIR Spectrometer. The release rate kinetics of the formulations was analyzed and the data obtained were fitted into Zero order, First order, Higuchi model and Kozmeyer Peppas model. Results: The pre-formulation study results obtained on various parameters on granules were found satisfactory. The granules obtained for the batches (F1-F12) were satisfactory. No rat holing, capping or sticking was observed during the flow of granules from the hopper. The maximum weight variation of the tablets was±1.8%, which falls within the acceptable range of±5%, hence the tablets passed the weight variation test. Hardness for tablets of all batches was in the range of 4.92 to 5.35 kg/cm², which falls above the limit of not less than 3.0 kg/cm². The floating lag time ranged from 35 s to 50 s. From the Table 5, it was found that the formulation F11 has the minimum floating lag time of 35 s and maximum total floating time of 15 h with 100.12% drug content. Conclusion: The effect of ingredients in the polyherbal tablet was analyzed, where HPMC contributed as the floating matrix, MCC to increase the bulk density of the tablet and sodium bicarbonate to initiate the dissolution process.
Synthesis and Evaluation of Cytotoxic Activity of 3-((1H-Benzo[d]imidazol-2-yl)methyl)-2-phenylquinazolin-4(3H)-one Derivatives on MCF-7 Cell Line
Authors: Singh Baljeet , Sharma Shailesh , Sinha Manish , Saga S.
Published: April 2023

Cancers, particularly, breast cancer is one of the deadliest disease in women and requires to be treated with lowest side-effects and toxicity. Quinazolinone and Benzimidazole nucleus are privileged nucleus with reported anti-cancer activity. Hence, combined derivatives of 3-((1H-Benzo[d]imidazol-2-yl)methyl)-2-phenylquinazolin-4(3H)-one E(1-8) were prepared and tested for cytotoxicity on MCF-7 cell line. Compound E6 showed 70.74% inhibition of cell growth as compared to 86.96% inhibition by standard doxorubicin.
Problems Faced by the Agricultural Workers at Faizabad District: An Analytical Study
Authors: Mohini Mohini , Kiran U. V. , Santoshi K. M.
Published: April 2023

Background: Agriculture workers are defined as workers who works in the field for the wages. They generate almost all of the food that we consume. Their health and safety have a direct impact on the growth of agricultural production. Aim: This study focused on risk factors and problems faced by agricultural workers. Materials and Methods: The present study included 150 agricultural workers. The study sample was selected using random sampling procedure in the Balramau area of Faizabad district. Data were collected using a self-structured interview schedule. Results: The study clearly revealed that maximum problems were faced by the respondents due to irrigation, fertilizers or pesticides, thresher or tractor causes hearing loss, sharp objects occurred cuts and injuries, breathing problems due to soil, and electrocution. Female agricultural workers faced more problems as compared to male agricultural workers. Conclusion: Agricultural workers do not have any regular employment, health security, job security, stable income, or social security protection. The analysis underlines that appropriate safety and health management may be feasible by empowering local infrastructure through government policies.
Combination effect of silymarin, quercetin, and hesperidin on anxiety and depression in 3 nitropropionic acid-induced rat model of huntington’s disease
Authors: Bhimanwar Arti A. , Ghaisas M. M. , Shete R. V.
Published: April 2023

Huntington’s disease is an autosomal-dominant, progressive neurodegenerative disorder with chorea, incoordination, cognitive decline, and behavioral difficulties, whereas bioflavonoids have the potential to promote anxiety and depression. The aim of this study was to investigate and summarize the synergistic effect of silymarin, quercetin, and hesperidin on anxiety and depression in 3-nitropropionic acid (3-NP)-induced rat model of Huntington’s disease. We divided animals into eight groups (n = 6) for different combination treatment with said bioflavonoids along with 3-NP. Anxiety and depression such as symptoms were assessed on 21st day post-treatment with elevated plus maze, light, and dark model and force swim test. Dopamine and serotonin level in the brain striatum were also measured after completion of behavioral analysis as these neurotransmitters are involved in anxiety and depression like behavior. We found that intraperitoneal administration of 3-NP (10 mg/kg B/W) for 21 days leads to anxiety and depression such as symptoms in male Wistar rats, whereas combinations of bioflavonoids ameliorate the symptoms. At the end of the study, we concluded that combination of silymarin, quercetin, and hesperidin is more effective in ameliorating anxiety and depression as compared to mono therapy.
In-vitro Antioxidant Capacity of Leaves of Tephrosia villosa Linn. (Leguminosae) in Various Solvent Extract
Authors: Nisha KM Jerun , Kiruthika M. Laxmi , Sheela D. Sathiya , Priya E. Shanthi , Kalimuthu K.
Published: April 2023

Introduction: Leaves of Tephrosia villosa belonging to the family fabaceae being used for the treatment of dropsy and diabetes. The present research work was under taken to investigate the in-vitro antioxidant activity of petroleum ether, chloroform, ethyl acetate, ethanol, methanol, and water extracts. Methods: In vitro antioxidant activities were carried out for six solvent extracts such as T. villosa leaf petroleum ether extract, T. villosa leaf chloroform extract, T. villosa leaf ethylacetate extract, T. villosa leaf ethanol extract, T. villosa leaf methanol extract, and T. villosa leaf water extract by standard methods. Five various antioxidant methods such as DPPH radical scavenging ability, superoxide radical scavenging potential, ABTS scavenging capacity, metal chelating ability, and reducing power assay (FRAP) were estimated. Results: Further investigation was carried out for in-vitro antioxidant activity and radical scavenging assay by calculating its % inhibition by means of IC50 values, all the extracts concentration has been adjusted to come under the linearity range and here reference standards ascorbic acid has been taken for the method suitability. Conclusion: The results revealed that leaves of this plant have antioxidant potential. Among these results, methenolic and water extract has more potent than the other extract. T. villosa Linn. (Fabaceae) leaves possess the antioxidant substance which may be potential responsible for the treatment of oxidative stress related diseases.
Review of Japanese Encephalitis Vaccines in India
Authors: Chatterjee Kripasindhu , Bhadra Atanu , Ray Swapan Kumar , Mukherjee Subhasis , Sen Sukanta
Published: April 2023

Japanese encephalitis virus belongs to the genus Flavivirus. Case fatality averages 30% and almost 50% of the survivors are left with permanent neuropsychiatric sequelae. Japanese encephalitis occurs in nearly all Asian countries including India. Patterns of JE transmission vary within individual countries and from year to year. In endemic areas, sporadic cases occur throughout the year. Japanese encephalitis or AES has been reported from 231 districts of 23 states. The best way to control JE in humans is through vaccination. Currently available vaccines in India are live attenuated, cell culture-derived SA 14-14-2, inactivated SA 14-14-2 vaccine (IC51; IXIARO® by Intercell and JEEV® by Biological Evans India Ltd.) and inactivated Vero cell culture-derived Kolar strain, 821564XY, JE vaccine (JENVAC® by Bharat Biotech). As 2006 position paper of WHO stated that mouse brain derived vaccines should be withdrawn and replaced by newer vaccines due to safety profile and as it is not available in our country now, this vaccine will not be discussed henceforth.
Artificial Intelligence: Applications in Nursing
Authors: Priyadarsini A. R. Ida Sweetlin
Published: April 2023

As in many areas of health-care delivery, nursing practice is being transformed by technological advances such as artificial intelligence (AI). Nurses play an integral role in health-care delivery system and it is essential for nurses to integrate these new technologies into practice. Nursing students, practicing nurses, nursing faculty, and nurse leaders need be aware of AI and its implications in nursing. This paper presents the significance of AI technologies application in health care specially nursing.
Satisfaction Measurement for in-hospital Services among Permanent Pacemaker Implantation Patients: A Pilot Study in Selected Hospital in Kolkata
Authors: Roy Moitreyee , Bhattacharyya Subarna , Patra Tushar Kanti
Published: April 2023

This study aimed to measure the satisfaction, as perceived by permanent pacemaker implantation (PPI) patients during stay in a selected hospital Kolkata. A non-experimental purposive sampling was chosen for selecting study participants. Moreover a qualitative cross sectional survey was conducted from the patients who were admitted in hospital for 1st time PPI. A semi-structured interview questionnaire was framed on the concept of SERVQUAL model, based on five areas, namely, assurance, tangible, reliability, responsiveness empathy, and the reliability. Data were collected from 27 selected participants who were staying hospital at least 3 days in male and female cardiology ward. Another qualitative interview captains five questionnaire was asked from study participants. In consideration of the level of patient satisfaction, majority (i.e., 55.65%) of the participants are satisfied. In case of highly satisfied and low satisfied group, it is quite low, that is, 22.22% for each group. It is also found that areas of assurance and responsiveness need some more attention from health professional so that patients may get confidence. A framework based on qualitative responses is proposed for further scope of improvement of the hospital services.
Assessment of Morphological Variation of the Mandibular Condylar Process, Coronoid Process, and Sigmoid Notch in Temporomandibular Joints of Adult Population Using Digital Orthopantomogram Based on Age and Gender –A Cross-sectional Study
Authors: Chatgile Rameshwar , Bhoosreddy Ajay , Bhadage Chetan , Sisodiya Sayali , Gadkari Tejal
Published: April 2023

Introduction: Orthopantomogram, a form of radiography that uses X-ray technology and is used in the diagnosis and treatment planning in various fields of dentistry, has been found to be less expensive than other advanced imaging modalities such as computed tomography or magnetic resonance imaging. Objective: The aim of the study was to evaluate the shape of mandibular condylar process, coronoid process, and sigmoid notch in various age groups and among the gender. Methods: A study was conducted using 150 digital orthopantomograms of patients. The different shapes of condylar process, coronoid process, and sigmoid notch were traced in computer using Galileos software. Statistical analysis was performed on the data obtained. A Chi-square test was performed to evaluate the P-value which was ascertained to be significant if <0.05. Results: The condylar shapes commonly observed among males and females were round, coronoid process shapes were triangular in shape and round, and sigmoid notches were wide. These variations in condylar process, coronoid process, and sigmoid notch are most commonly seen in the age group of 20–30 years. When compared between gender-wise and age-wise, there were no statistical significance differences found with these variations. Conclusion: In the present study, morphological variation in the shape of the condylar process, coronoid process, and sigmoid notch was observed among the adult population. Knowing these variations can help detect gender, age, and diagnoses of pathologies.
Multi-criteria optimization approach to the design of small dams’ systems along mountainous stream beds
Authors: Kontos Yiannis Nikolaos , Bampekos Ioannis , Katsifarakis Konstantinos L.
Published: April 2023

This paper aims at the optimal design of a system of small solid barrier-type stone dams in a semi-realistic study case, determining the number, location and height of dams and a borrow-pit (BP)'s location for benefit maximization and cost minimization of objectives: (a) maximum flood protection, (b) maximum underlying aquifers' artificial recharge, (c) minimum dams' construction cost and (d) minimum stonework transportation cost. The simplified conceptual model involves no hydraulic simulation; flow characteristics are not considered, while no dam is assumed to affect another dam's benefit/cost values. Hence, all partial benefit/cost values can be separately pre-calculated, for each one of the available dam locations for all available heights and BP locations, deriving from data concerning topography, geology/soil, land uses, construction and transportation costs. Any solution proposing a system of dams of various heights and a BP exhibits a total management value equal to the sum of the respective partial benefit/cost values of each dam. The multi-objective optimization problem is formulated into a single-objective minimization problem; the difference of costs minus benefits is to be minimized. Simple, elitist genetic algorithms (GAs) are used, coupled with sophisticated post-processing of results, able to produce optimized design solutions and strategies.
Projection of net irrigation requirement over India using a bias-corrected spatially downscaled dataset
Authors: Nengzouzam Grace , Bandyopadhyay Arnab , Bhadra Aditi
Published: April 2023

With the country's economy directly dependent on food grain production, accurate estimation of the net irrigation requirement (NIR) of crops is essential for maximizing production. The daily IMD precipitation (0.25° × 0.25°) and temperature (1° × 1°) gridded datasets (1971–2010) were considered for the present scenario. Two satellite-based crop coefficient layers were prepared for the study: (i) kc_EEFlux, the evaporative fraction layer from earth engine evapotranspiration flux (EEFlux) and (ii) kc_FEWS, the ratio of the famine early warning system network (FEWSNET) monthly actual evapotranspiration (ET) (ETa) to ET0_FEWSNET layers. The NIR was estimated for three different cropping pixels derived from the land-use land cover (LULC) map of India, namely, Kharif-only, Rabi-only, and double/triple pixels using ‘ET0 and NIR toolbar’. The National Aeronautics and Space Administration (NASA)'s Earth Exchange Global Daily Downscaled Projections dataset were employed for projecting the future scenario. Results showed discrepancies in the extreme values of FAO56-Penman–Monteith (PM) and Hargreaves–Samani's estimated reference ET (ET0) but followed a similar trend in all months (R2 = 0.88). Results also suggested that FEWSNET offered more reliable estimates of NIR over EEFlux. The projected ensemble NIR indicated a probable negative relative change during the Kharif season (RCP4.5: from −14.47 to −7.25%; RCP8.5: from −11.45 to −5.59%) while a probable positive relative change during the Rabi season (RCP4.5: 3.30–5.21%; RCP8.5: 2.34–8.83%).
A Sex-Specific Evaluation of Dental Students’ Ability to Perform Subgingival Debridement: Randomized Trial
Authors: Frank Ariadne Charis , Jennrich Linda , Kanzow Philipp , Wiegand Annette , Krantz-Schäfers Christiane
Published: April 2023

Background

A successful periodontitis treatment demands good manual skills. A correlation between biological sex and dental students’ manual dexterity is currently unknown.

Objective

This study examines performance differences between male and female students within subgingival debridement.

Methods

A total of 75 third-year dental students were divided by biological sex (male/female) and randomly assigned to one of two work methods (manual curettes n=38; power-driven instruments n=37). Students were trained on periodontitis models for 25 minutes daily over 10 days using the assigned manual or power-driven instrument. Practical training included subgingival debridement of all tooth types on phantom heads. Practical exams were performed after the training session (T1) and after 6 months (T2), and comprised subgingival debridement of four teeth within 20 minutes. The percentage of debrided root surface was assessed and statistically analyzed using a linear mixed-effects regression model (P<.05).

Results

The analysis is based on 68 students (both groups n=34). The percentage of cleaned surfaces was not significantly different (P=.40) between male (mean 81.6%, SD 18.2%) and female (mean 76.3%, SD 21.1%) students, irrespective of the instrument used. The use of power-driven instruments (mean 81.3%, SD 20.5%) led to significantly better results than the use of manual curettes (mean 75.4%, SD 19.4%; P=.02), and the overall performance decreased over time (T1: mean 84.5%, SD 17.5%; T2: mean 72.3%, SD 20.8%; P<.001).

Conclusions

Female and male students performed equally well in subgingival debridement. Therefore, sex-differentiated teaching methods are not necessary.
Survey Paper: Automatic Title Generation for Text with RNN and Pre-trained Transformer Language Model
Authors: Lodhwal Vishal , Choudhary Gowri
Published: April 2023

Abstract: Nowadays huge amounts of text data are available due to the evolution of the Internet. Although search engines are used to select text data, it is unfeasible to go through the entire search results of text that are related to search intent. Therefore, text summarization is the only method by which we can reduce text data without the loss of information. A new method for Title or Text generation is the Transformer language model that has been trained i.e. GPT-2, GPTNeo, Chat-GPT, and LSTM Model of RNN by which we can generate catchy titles to take readers’ attention and attract them to read a full article. This paper has discovered recent literature on all the previously mentioned topics which are related to Title or Text generators and examines several methods which propose to make use of various language models. The suggested approaches are also contrasted with one another to highlight their unique advantages, and to suggest constantly better ways.
Survey on Forecasting of E-Commerce Product Rating
Authors: Akther Sanan , D. E Vedananda , Prasad Skanda , G.V Vikas Rao , T. S Vishwas
Published: April 2023

Abstract: E-commerce websites are presently the most popular online shopping platforms for a broad spectrum of products. Users are now provided with numerous different sites to access and search for the needed items on the market. Several tactics are now being applied to evaluate and understand client behaviour in order to enhance corporate growth. One such method is the online product rating, which is a critical statistic for understanding a product's acceptance by users.
Intertextual Character of Poetic Philological Discourse
Authors: Antonova Elena N.
Published: April 2023

The poetic-philological discourse functions as a linguocultural phenomenon in the Russian intertext. The relevance of the study is due to the consistent systematization of knowledge about philological poetry as a special type of discourse, a multidimensional analysis of the literary works of poets-phraseologists is carried out. The purpose of the work undertaken was to form ideas about the elocution of the scientist’s artistic world, that is, the materialization of the cognitive program, in the creative workshop of his philological experience. Poetry collections of modern researchers of the Russian language, specialists in the field of linguoculturology and phraseology, paremiology, and byword studies served as materials. On the basis of the predecessor works devoted to the Russian text, discourse, intertext, interpretative, linguoculturological and axiological accents are placed in the study of idiostyle, taking into account the professional position of the author. The methods of work included the observation of philological poetry and the description of its characteristic features, the systematization of the verbal tools of philologists-poets, analytical work with theoretical and factual material, deepening and expanding existing research on the specifics of Russian intertext and discourse. The main points of the study were the coverage of the intertextual properties of Russian discourse in the linguoculurological aspect, the analysis of the distinctive features of philological poetry in the conditions of intertext and in the interaction of creativity and science. The conclusions made in the course of the study determined the unique intertextual position of the poetic experiences of linguists, based on the shift of the center of poetic thought towards epistemological tendencies. In conclusion, the innovative nature of images, symbols, ideas in philological poetry is noted, directions for its further study, as well as the study of Russian intertext and poetic discourse, are outlined.
Paroemia in the Context of Modern French Public Internet Advertisin
Authors: Anisimova Ekatherina D. , Anisimov Vladislav E. , Denisenko Vladimir N.
Published: April 2023

The research is devoted to the study of the functioning of paremias in the discourse of modern French social advertising. The relevance of the problem under consideration lies in the insufficient knowledge of the representation features of the French language paroemiological fund in modern public Internet advertising published in France. The utmost aim of the paper is to describe the main constitutive and linguistic features of modern French public Internet advertising and the specifics of the realisation of language paremiological units in it. The research material includes 312 objects of French public advertising distributed on the Internet in the period from 2016 to 2022. The study used methods of comparative, lexicographic and statistical analysis, as well as the method of semantic analysis of linguistic units. The results revealed that the use of paroemias as figure of speech in modern French public advertising is insignificant, due to the fact that the semantically complex message of the original proverbs and sayings can significantly narrow the target audience of public advertising. The use of paroemias as an element of public advertising (In its original, partially or completely modified form) makes it more intellectual and attractive directly to native French speakers.
Quantitative tracking of change in tail color in blue-tailed skink (Plestiodon elegans) throughout its growth cycle
Authors: Yang Chen , Chen Siheng , Wang Jie
Published: April 2023

Ontogenetic color change in animals is an interesting evolution-related
phenomenon that has been studied by evolutionary biologists for decades.
However, the performance of quantitative and continuous color
measurements throughout the life cycle of animals is a challenge. To
understand the rhythm of change in tail color and sexual dichromatism,
we used a spectrometer to measure the tail color of blue-tailed skink
(Plestiodon elegans) from birth to sexual maturity. Lab color space was
selected due to its simple, fast, and accurate and depends on the visual
sense of the observer for measuring the tail color of skinks. A strong
relationship was observed between color indexes (values of L*, a*, b*)
and growth time of skink. The luminance of tail color decreased from
juveniles to adults in both sexes. Moreover, we observed differences in
color rhythms between the sexes, which may be influenced by different
behavioral strategies employed by them. This study provides continuous
measurements of change in tail color in skinks from juveniles to adults
and offers insights into their sex-based differences. Our findings
explain the potential factors that drive dichromatism between the sexes
of lizards and is expected to serve as a reference for future studies
that explore possible mechanisms of ontogenetic color change in
reptiles.
Isolasi Bakteri Asam Laktat dari Susu Kuda Liar dan Potensi Antibakteri pada Susu Kuda Liar Sumbawa
Authors: Baso Manguntung  , Abdhi Surya Perkasa  , Yulianti Kusdianawati  , Heru Piria Hastuti  , Arif Muhamad
Published: April 2023

Pulau Sumbawa yang terletak tepat di provinsi Nusa Tenggara Barat menjadi salah satu pulau yang menghasilkan Susu Kuda Liar Sumbawa terbesar di Indonesia. Susu kuda asal Sumbawa sangat diminati karena khasiatnya yang sangat baik untuk kesehatan. Tujuan dilakukannya penelitian ini adalah untuk mengisolasi bakteri asam laktat dari susu kuda liar Sumbawa dan mengetahui potensi kemampuan antibakteri dari susu kuda liar Sumbawa. Penelitian ini dilakukan dengan mengisolasi bakteri asam laktat dari susu kuda liar Sumbawa dengan metode spread plate menggunakan media MRSA. Kemudian uji antibakteri susu kuda liar Sumbawa dilakukan dengan metode difusi paper disk terhadap tiga spesies bakteri patogen berbeda yaitu Eschericia coli, Staphylococcus aureus, Vibrio cholerae dan perlakuan kontrol (-) akuades, kontrol (+) kanamisin. Pengujian menggunakan susu kuda liar Sumbawa dengan variasi konsentrasi berbeda yaitu 20, 40, 60, 80, dan 100. Hasil penelitian menunjukkan terdapat bakteri asam laktat pada susu kuda liar Sumbawa dengan tumbuhnya koloni berwarna putih pada media MRSA. Pada pengujian antibakteri terlihat adanya zona hambat pada semua perlakuan konsentrasi dan kontrol (+). Diameter zona hambat terbesar dilihat pada konsentrasi 100% yaitu Staphylococcus aureus (1,996 mm), Eschericia coli (1,982 mm), dan Vibrio cholerae (2,020 mm) sedangkan kontrol (-) tidak menunjukkan adanya zona hambat. Sehingga susu kuda liar Sumbawa ini berpotensi menghambat terhadap bakteri patogen.