bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of Foveal Avascular Zone and Macular Vascular Plexus Density in Children With Unilateral Amblyopia: A Systemic Review and Meta-Analysis
Authors: Gao Lei , Gao Yang , Hong Fengrong , Zhang Peng , Shu Xiangwen
Published: May 2021

Purpose: To examine the quantitative measurements of OCTA in children with amblyopia using the meta-analysis methodology.

Methods: PubMed, Embase, and Cochrane library were searched for available papers up to March 2021. Weighted mean differences (WMD) were used to compare the retina parameters between the eyes with amblyopia and the contralateral eyes or healthy control eyes.

Results: Twelve studies were included. When considering the parafovea, the microvessel density was reduced in amblyopic eyes compared with healthy control eyes in the superficial capillary plexus (SCP) in 6 × 6 volume scan (WMD = −2.12, 95%CI: −3.24, −0.99) but not SCP in 3 × 3 volume scan (WMD = −1.43, 95%CI: −2.96, 0.11). In the deep capillary plexus (DCP), amblyopia did not decrease vessel density in the 6 × 6 volume scan (WMD = −2.22, 95%CI: −5.86, 1.42; I2 = 79.6%, P = 0.008), but a difference was observed in the whole eye 3 × 3 (WMD = −1.95, 95%CI: −3.23, −0.67; I2 = 27.5%, P = 0.252). There were no significant differences in the foveal avascular zone area and foveal thickness between amblyopic eyes and healthy control eyes. There were no significant differences in microvessel density, foveal avascular zone area, and foveal thickness between amblyopic eyes and fellow eyes.

Conclusion: According to OCTA, amblyopic eyes had lower vessel density in parafoveal SCP and DCP compared with healthy control eyes, but not compared with fellow eyes. There were no significant differences regarding the foveal avascular zone area and foveal thickness between amblyopic and non-amblyopic eyes.
The Synergistic Effects of 5-Aminosalicylic Acid and Vorinostat in the Treatment of Ulcerative Colitis
Authors: He Long , Wen Shuting , Zhong Zhuotai , Weng Senhui , Jiang Qilong , Mi Hong , Liu Fengbin
Published: May 2021

Background: The drug 5-aminosalicylic acid (5-ASA) is the first-line therapy for the treatment of patients with mild-to-moderate ulcerative colitis (UC). However, in some cases, 5-ASA cannot achieve the desired therapeutic effects. Therefore, patients have to undergo therapies that include corticosteroids, monoclonal antibodies or immunosuppressants, which are expensive and may be accompanied by significant side effects. Synergistic drug combinations can achieve greater therapeutic effects than individual drugs while contributing to combating drug resistance and lessening toxic side effects. Thus, in this study, we sought to identify synergistic drugs that can act synergistically with 5-ASA.

Methods: We started our study with protein-metabolite analysis based on peroxisome proliferator-activated receptor gamma (PPARG), the therapeutic target of 5-ASA, to identify more additional potential drug targets. Then, we further evaluated the possibility of their synergy with PPARG by integrating Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment analysis, pathway-pathway interaction analysis, and semantic similarity analysis. Finally, we validated the synergistic effects with in vitro and in vivo experiments.

Results: The combination of 5-ASA and vorinostat (SAHA) showed lower toxicity and mRNA expression of p65 in human colonic epithelial cell lines (Caco-2 and HCT-116), and more efficiently alleviated the symptoms of dextran sulfate sodium (DSS)-induced colitis than treatment with 5-ASA and SAHA alone.

Conclusion: SAHA can exert effective synergistic effects with 5-ASA in the treatment of UC. One possible mechanism of synergism may be synergistic inhibition of the nuclear factor kappa B (NF-kB) signaling pathway. Moreover, the metabolite-butyric acid may be involved.
Time-Varying Volatility in Bitcoin Market and Information Flow at Minute-Level Frequency
Authors: Barjašić Irena , Antulov-Fantulin Nino
Published: May 2021

In this article, we analyze the time series of minute price returns on the Bitcoin market through the statistical models of the generalized autoregressive conditional heteroscedasticity (GARCH) family. We combine an approach that uses historical values of returns and their volatilities—GARCH family of models, with a so-called Mixture of Distribution Hypothesis, which states that the dynamics of price returns are governed by the information flow about the market. Using time series of Bitcoin-related tweets, the Bitcoin trade volume, and the Bitcoin bid–ask spread, as external information signals, we test for improvement in volatility prediction of several GARCH model variants on a minute-level Bitcoin price time series. Statistical tests show that GARCH(1,1) and cGARCH(1,1) react the best to the addition of external signals to model the volatility process on out-of-sample data.
Multi-Scale Simulation of Two-Dimensional Chloride Transport Under the Effect of Bending Load in Concrete
Authors: Zhang Lijuan , Zhang Jianjian , Sun Guowen , Liu Zhiyong
Published: May 2021

Chloride transport in marine concrete under loading is the main cause of its structural deterioration. The traditional numerical simulation assumes that the coefficient of chloride transport is constant, resulting in a large deviation in the prediction results. Based on the porous medium theory, micromechanics theory, and the idea of equivalent homogenization, a multi-scale model of the effective diffusion variable coefficient of chloride transport under bending load was established, which was calculated and programmed by the numerical analysis. The results show that the prediction values of the two-dimensional variable coefficient model are basically consistent with those in the literature, and the prediction accuracy is significantly improved. In addition, the theoretical simulation proves that the bending load affects the porosity of the cement matrix, and then the diffusion coefficient of chloride is changed in concrete. The compression zone can slow down the chloride transport process, while tension zone will accelerate it. The chloride concentration under tension zone is 42.1% higher than that under compression zone when the diffusion time is 200 days and the concrete depth is 15 mm.
High-Efficiency Asymmetric Transmission of Red-Near-Infrared Light Based on Chiral Metamaterial
Authors: Tian Yu , Chen Zhiwei , Ren Fang-Fang , Du Qingguo , Li Zhengying
Published: May 2021

Designing and fabricating high-performance polarization converters that exhibit asymmetric transmission (AT), for light with different circularly/linearly polarized states with opposite propagating directions, are in high demand. The AT phenomenon leads to potential applications as isolators and circulators in information and communication systems. We propose a chiral metamaterial structure with high AT efficiency for two types of linearly orthogonal polarized red-near-IR light in two opposite incident directions. Theoretical results showed that the proposed chiral metamaterial structure achieves cross-polarization conversion where the polarization conversion ratio (PCR) is over 90%, in a broadband wavelength range from 715 to 810 nm, for both forward-propagating linearly polarized light and backward-propagating orthogonal linearly polarized light. The physical mechanisms of the polarization converter with the AT have been investigated. It was confirmed that the Fabry–Perot-like resonance and coupling between electric and magnetic dipoles lead to highly efficient asymmetric polarization conversion for two orthogonal linearly polarized light. Additionally, the conversion efficiency and bandwidth of the polarization converter are successfully optimized by adjusting the related structure parameters.
EM Estimation of the X-Ray Spectrum With a Genetically Optimized Step-Wedge Phantom
Authors: Li Mengzhou , Fan Feng-Lei , Cong Wenxiang , Wang Ge
Published: May 2021

The energy spectrum of an X-ray tube plays an important role in computed tomography (CT), and is often estimated from physical measurement of dedicated phantoms. Usually, this estimation problem is reduced to solving a system of linear equations, which is generally ill-conditioned. In this paper, we optimize a phantom design to find the most effective combinations of thicknesses for different materials. First, we analyze the ill-posedness of the energy spectrum inversion when the number of unknown variables (N) and measurements (M) are equal, and show the condition number of the system matrix increases exponentially with N if the transmission thicknesses are linearly changed. Then, we present a genetic optimization algorithm to minimize the condition number of the system matrix in a general case (M < N) with respect to the selection of thicknesses and types of phantom materials. Finally, in the simulation with Poisson noise we study the accuracy of the spectrum estimation using the expectation-maximum algorithm. Our results indicate that the proposed method allows high-quality spectrum estimation, and the number of measurements is reduced over two thirds of that required by the widely-used method using a phantom with linearly-changed thicknesses.
Emergency Medicine Cases in Underwater and Hyperbaric Environments: The Use of in situ Simulation as a Learning Technique
Authors: Paganini Matteo , Mormando Giulia , Savino Sandro , Garetto Giacomo , Tiozzo Giulia , Camporesi Enrico M. , Fabris Fabrizio , Bosco Gerardo
Published: May 2021

Introduction

Hyperbaric chambers and underwater environments are challenging and at risk of serious accidents. Personnel aiming to assist patients and subjects should be appropriately trained, and several courses have been established all over the world. In healthcare, simulation is an effective learning technique. However, there have been few peer-reviewed articles published in the medical literature describing its use in diving and hyperbaric medicine.

Methods

We implemented the curriculum of the Master’s degree in hyperbaric and diving medicine held at the University of Padova with emergency medicine seminars created by the faculty and validated by external experts. These seminars integrated traditional lectures and eightin situsimulation scenarios.

Results

For the hyperbaric medicine seminar, simulations were carried out inside a real hyperbaric chamber at the ATIP Hyperbaric Treatment Centre, only using air and reproducing compression noise without pressurization to avoid damages to the manikins. The four scenarios consisted of hyperoxic seizures, pneumothorax, hypoglycemia, and sudden cardiac arrest. Furthermore, we added a hands-on session to instruct participants to prepare an intubated patient undergoing hyperbaric oxygen treatment with a checklist and simulating the patient transfer inside and outside the hyperbaric chamber. The diving medicine seminar was held at the Y-40 The Deep Joy pool in Montegrotto Terme (Italy), also involving SCUBA/breath-hold diving (BHD) instructors to rescue subjects from the water. These diving medicine scenarios consisted of neurologic syndrome (“taravana/samba”) in BHD, drowning of a breath-hold diver, pulmonary barotrauma in BHD, and decompression illness in a SCUBA diver.

Conclusion

With this experience, we report the integration of simulation in the curriculum of a teaching course in diving and hyperbaric medicine. Future studies should be performed to investigate learning advantages, concept retention, and satisfaction of participants.
Retrospective Analysis of Training and Its Response in Marathon Finishers Based on Fitness App Data
Authors: Zrenner Markus , Heyde Christian , Duemler Burkhard , Dykman Solms , Roecker Kai , Eskofier Bjoern M.
Published: May 2021

Objective: Finishing a marathon requires to prepare for a 42.2 km run. Current literature describes which training characteristics are related to marathon performance. However, which training is most effective in terms of a performance improvement remains unclear.

Methods: We conducted a retrospective analysis of training responses during a 16 weeks training period prior to an absolved marathon. The analysis was performed on unsupervised fitness app data (Runtastic) from 6,771 marathon finishers. Differences in training volume and intensity between three response and three marathon performance groups were analyzed. Training response was quantified by the improvement of the velocity of 10 km runs Δv10 between the first and last 4 weeks of the training period. Response and marathon performance groups were classified by the 33.3rd and 66.6th percentile of Δv10 and the marathon performance time, respectively.

Results: Subjects allocated in the faster marathon performance group showed systematically higher training volume and higher shares of training at low intensities. Only subjects in the moderate and high response group increased their training velocity continuously along the 16 weeks of training.

Conclusion: We demonstrate that a combination of maximized training volumes at low intensities, a continuous increase in average running speed up to the aimed marathon velocity and high intensity runs ≤ 5 % of the overall training volume was accompanied by an improved 10 km performance which likely benefited the marathon performance as well. The study at hand proves that unsupervised workouts recorded with fitness apps can be a valuable data source for future studies in sport science.
Hypertrophy of Adipose Tissues in Quail Embryos by in ovo Injection of All-Trans Retinoic Acid
Authors: Kim Dong-Hwan , Lee Joonbum , Kim Sanggu , Lillehoj Hyun S. , Lee Kichoon
Published: May 2021

Excessive adipose accretion causes health issues in humans and decreases feed efficiency in poultry. Although vitamin A has been known to be involved in adipogenesis, effects of all-trans retinoic acid (atRA), as a metabolite of vitamin A, on embryonic adipose development have not been studied yet. Avian embryos are developing in confined egg environments, which can be directly modified to study effects of nutrients on embryonic adipogenesis. With the use of quail embryos, different concentrations of atRA (0 M to 10 μM) were injected in ovo at embryonic day (E) 9, and adipose tissues were sampled at E14. Percentages of fat pad weights in embryo weights were significantly increased in the group injected with 300 nM of atRA. Also, among three injection time points, E5, E7, or E9, E7 showed the most significant increase in weight and percentage of inguinal fat at E14. Injection of atRA at E7 increased fat cell size in E14 embryos with up-regulation of pro-adipogenic marker genes (Pparγ and Fabp4) and down-regulation of a preadipocyte marker gene (Dlk1) in adipose tissues. These data demonstrate that atRA promotes hypertrophic fat accretion in quail embryos, implying important roles of atRA in embryonic development of adipose tissues.
Photosynthetic and Photoprotective Responses to Steady-State and Fluctuating Light in the Shade-Demanding Crop Amorphophallus xiei Grown in Intercropping and Monoculture Systems
Authors: Zhang Jinyan , Shuang Shengpu , Zhang Ling , Xie Shiqing , Chen Junwen
Published: May 2021

Photosynthetic and photoprotective responses to simulated sunflecks were examined in the shade-demanding crop Amorphophallus xiei intercropped with maize (intercropping condition) or grown in an adjacent open site (monoculture condition). Both intercropping leaves and monoculture leaves exhibited very fast induction responses. The times taken to achieve 90% maximum net photosynthetic rate in intercropping leaves and monoculture leaves were 198.3 ± 27.4 s and 223.7 ± 20.5 s during the photosynthetic induction, respectively. During an 8-min simulated sunfleck, the proportion of excess excited energy dissipated through the xanthophyll cycle-dependent pathway (ΦNPQ) and dissipated through constitutive thermal dissipation and the fluorescence (Φf, d) pathway increased quickly to its maximum, and then plateaued slowly to a steady state in both intercropping and monoculture leaves. When the illumination was gradually increased within photosystem II (PSII), ΦNPQ increased quicker and to a higher level in monoculture leaves than in intercropping leaves. Relative to their monoculture counterparts, intercropping leaves exhibited a significantly lower accumulation of oxygen free radicals, a significantly higher content of chlorophyll, and a similar content of malondialdehyde. Although monoculture leaves exhibited a larger mass-based pool size of xanthophyll cycle [V (violaxanthin) + A (antheraxanthin) + Z (zeaxanthin)] than intercropping leaves, intercropping leaves had a higher ratio of (Z + A)/(V + Z + A) than monoculture leaves. intercropping leaves had markedly higher glutathione content and ascorbate-peroxidase activity than their monoculture counterparts. Similar activities of catalase, peroxidase, dehydroascorbate reductase, and monodehydroascorbate were found in both systems. Only superoxide dismutase activity and ascorbate content were lower in the intercropping leaves than in their monoculture counterparts. Overall, the xanthophyll cycle-dependent energy dissipation and the enzymatic antioxidant defense system are important for protecting plants from photooxidation in an intercropping system with intense sunflecks.
Electronic Performance Monitoring in the Digital Workplace: Conceptualization, Review of Effects and Moderators, and Future Research Opportunities
Authors: Kalischko Thomas , Riedl René
Published: May 2021

The rise of digital and interconnected technology within the workplace, including programs that facilitate monitoring and surveillance of employees is unstoppable. The COVID-19-induced lockdowns and the resulting increase in home office adoption even increased this trend. Apart from major benefits that may come along with such information and communication technologies (e.g., productivity increases, better resource planning, and increased worker safety), they also enable comprehensive Electronic Performance Monitoring (EPM) which may also have negative effects (e.g., increased stress and a reduction in job satisfaction). This conceptual article investigates EPM to better understand the development, adoption, and impact of EPM systems in organizations. The EPM literature published since the 1980s constitutes the basis for this conceptual article. We present a framework which is intended to serve as foundation for future studies. Moreover, we reviewed more than three decades of empirical EPM research and identified six major outcomes that are influenced by the use of an EPM system, as well as a large number of moderator variables. Based on our conceptual analyses and the resulting insights, which also include privacy, ethical, and cultural considerations, we discuss future research opportunities where we also refer to design implications for EPM systems.
From Non-symbolic to Symbolic Proportions and Back: A Cuisenaire Rod Proportional Reasoning Intervention Enhances Continuous Proportional Reasoning Skills
Authors: Abreu-Mendoza Roberto A. , Coulanges Linsah , Ali Kendell , Powell Arthur B. , Rosenberg-Lee Miriam
Published: May 2021

The persistent educational challenges that fractions pose call for developing novel instructional methods to better prepare students for fraction learning. Here, we examined the effects of a 24-session, Cuisenaire rod intervention on a building block for symbolic fraction knowledge, continuous and discrete non-symbolic proportional reasoning, in children who have yet to receive fraction instruction. Participants were 34 second-graders who attended the intervention (intervention group) and 15 children who did not participate in any sessions (control group). As attendance at the intervention sessions was irregular (median = 15.6 sessions, range = 1–24), we specifically examined the effect of the number of sessions completed on their non-symbolic proportional reasoning. Our results showed that children who attended a larger number of sessions increased their ability to compare non-symbolic continuous proportions. However, contrary to our expectations, they also decreased their ability to compare misleading discretized proportions. In contrast, children in the Control group did not show any change in their performance. These results provide further evidence on the malleability of non-symbolic continuous proportional reasoning and highlight the rigidity of counting knowledge interference on discrete proportional reasoning.
Online Processing of Temporal Agreement in a Grammatical Tone Language: An ERP Study
Authors: Tsiwah Frank , Bastiaanse Roelien , van Rij Jacolien , Popov Srđan
Published: May 2021

Previous electrophysiological studies that have examined temporal agreement violations in (Indo-European) languages that use grammatical affixes to mark time reference, have found a Left Anterior Negativity (LAN) and/or P600 ERP components, reflecting morpho-syntactic and syntactic processing, respectively. The current study investigates the electrophysiological processing of temporal relations in an African language (Akan) that uses grammatical tone, rather than morphological inflection, for time reference. Twenty-four native speakers of Akan listened to sentences with time reference violations. Our results demonstrate that a violation of a present context by a past verb yields a P600 time-locked to the verb. There was no such effect when a past context was violated by a present verb. In conclusion, while there are similarities in both Akan and Indo-European languages, as far as the modulation of the P600 effect is concerned, the nature of this effect seems to be different for these languages.
Music Listening in Times of COVID-19 Outbreak: A Brazilian Study
Authors: Ribeiro Fabiana Silva , Lessa João Paulo Araújo , Delmolin Guilherme , Santos Flávia H.
Published: May 2021

The COVID-19 outbreak required diverse strategies, such as social distancing and self-isolation, to avoid a healthcare system crisis. However, these measures have been associated with the onset or increase of anxiety and depression symptoms in the population. Music listening was previously shown to regulate emotion, consequently reducing depression symptoms. Since previous studies with Brazilian samples have already shown a high prevalence of depressive symptoms during the first confinement period, the aim of this study was threefold: (i) to compare groups with severe depression symptoms and no depression in what concerns to demographic and socio-economic factors as well as symptoms of anxiety and resilience levels, (ii) to explore changes in music listening daily routine during the confinement measures by both groups (no depression and severe depression), and (iii) to investigate which were the main factors influencing both two groups to music listening during the COVID-19 pandemic. This cross-sectional study included 494 Brazilian respondents aged 18 years and above. Our online survey comprised demographics, socio-economic, and COVID-19 related questionnaires, with questions regarding music listening used during social distancing measures on which the participants rated how much each of the 41 potential reasons for listening to music changed in importance compared to the situation before the pandemic and also the evaluation of anxiety, depression, and resilience levels. The respondents with severe depression were younger and showed higher levels of anxiety symptoms and lower resilience level. Furthermore, they were increasingly likely to listen to music to feel emotionally better with the situation, to feel comfort, to forget problems, to be energetic, to decrease sad feelings, to relax, to cheer up, to forget concerns, to express feelings, to reduce anxiety, to remember better times, to relieve boredom, to mentally stimulate themselves, and to ward off stressful thoughts compared to the participants with no depression. The exploratory factor analysis (FA) identified four types of music listening functions during social distancing measures: negative mood management, cognitive functioning, positive mood management, and physical involvement, in which the participants with severe depression revealed significant differences compared to non-depressed participants for the negative mood management factor, which shows the importance of music listening to regulate their negative emotions. As a conclusion, we can argue that most of our respondents used music listening to cope with and regulate their moods during confinement, especially those who presented with severe depression symptoms.
Effects of Chinese Mind-Body Exercises on Executive Function in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis
Authors: Ren Fei-Fei , Chen Feng-Tzu , Zhou Wen-Sheng , Cho Yu-Min , Ho Tsung-Jung , Hung Tsung-Min , Chang Yu-Kai
Published: May 2021

Chinese mind-body exercises (CMBEs) are positively associated with executive function (EF), but their effects on EF, from synthesized evidence using systematic and meta-analytic reviews, have not been conducted. Therefore, the present systematic review with meta-analysis attempted to determine whether CMBEs affect EF and its sub-domains, as well as how exercise, sample, and study characteristics moderate the causal relationship between CMBEs and EF in middle-aged and older adults. Seven electronic databases were searched for relevant studies published from the inception of each database through June 2020 (PubMed, Web of Science, Embase, Cochrane Controlled Trials Register, Wanfang, China National Knowledge Infrastructure, and Weipu). Randomized controlled trials with at least one outcome measure of CMBEs on EF in adults of mean age ≥ 50 years with intact cognition or mild cognitive impairment (MCI) and with or without chronic diseases were included. A total of 29 studies (N = 2,934) ultimately were included in this study. The results indicated that CMBEs improved overall EF (Standardized Mean Differences = 0.28, 95% CI 0.12, 0.44), as well as its sub-domains of working memory and shifting. The beneficial effects of CMBEs on EF occurred regardless of type (Tai Chi, Qigong), frequency of group classes (≤2 time, 3-4 time, ≥5 times), session time (≤45 min, 46-60 min), total training time (≥150 to ≤300 min, >300 min), and length of the CMBEs (4-12 week, 13-26 week, and >26 week), in addition to that more frequent participation in both group classes and home practice sessions (≥5 times per week) resulted in more beneficial effects. The positive effects of CMBEs on EF were also demonstrated, regardless of participants mean age (50-65 years old, >65 years old), sex (only female, both), and cognitive statuses (normal, MCI, not mentioned), health status (with chronic disease, without chronic disease), as well as training mode (group class, group class plus home practice) and study language (English, Chinese). This review thus suggests that CMBEs can be used as an effective method with small to moderate and positive effects in enhancing EF, and that more frequent group classes and home practice sessions may increase these effects. However, certain limitations, including strictly design studies, limited ES (effect size) samples for specific variables, and possible biased publications, required paying particular attention to, for further exploring the effects of CMBEs on EF.
Fitnesser’s Intrinsic Motivations of Green Eating: An Integration of Theory of Planned Behavior and Hedonic-Motivation System Adoption Model
Authors: Chen Yuan , Lee Bey-Fen , Lu Yen-Cheng
Published: May 2021

Global climate change arouses people’s attention to environmental protection and, therefore, changes consumption habits. Food overconsumption not only produces extra waste but also pollutes the environment. Therefore, it is important to understand the factors that motivate people to eat green, an eco-friendly way to consume food. To keep the body in good shape, the fitnessers concern more about diet than the general people. This study explored intrinsic motivations, such as social recognition, environmental ethics, curiosity, joy of purchase, perceived usefulness, subjective norm, and perceived behavior control as constructs that affect fitnesser’s green eating intention. All constructs except curiosity have significant impacts on behavior intention. The results demonstrate that social recognition and environmental ethics have significant effects on curiosity, joy of purchase, perceived usefulness, subjective norm, and perceived behavior control. The mediation effects between social recognition and behavior intention are not supported. The mediators between environmental ethics and behavior intention are joy of purchase, perceived usefulness, subjective norm, and perceived behavior control.
Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality
Authors: Zhang Qi , Yun Yajun , An Huimei , Zhao Wenxuan , Ma Ting , Wang Zhiren , Yang Fude
Published: May 2021

The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD.
The Alteration of Salivary Immunoglobulin A in Autism Spectrum Disorders
Authors: Gong Wuyi , Qiao Yanan , Li Bosheng , Zheng Xiaoguo , Xu Ruihuan , Wang Mingbang , Mi Xiaohui , Li Yongming
Published: May 2021

Objectives: Autism spectrum disorders (ASD) are neurodevelopmental disorders with changes in the gut and oral microbiota. Based on the intimate relationship between the oral microbiota and oral mucosal immunity, this study aimed to investigate changes in salivary immunoglobulin A (IgA) level in ASD and the underlying mechanism for any such changes.

Methods: We recruited 36 children diagnosed with ASD and 35 normally developing children and measured their salivary IgA content using enzyme-linked immunosorbent assay (ELISA). The valproate (VPA) -treated ASD mouse model was established by prenatal exposure to valproate and mouse salivary IgA content was also quantified by ELISA. The submandibular glands of VPA and control mice were isolated and analyzed using qRT-PCR, immunofluorescence staining, and flow cytometry. ASD-related Streptococci were co-incubated with the human salivary gland (HSG) cell line, and western blotting was used to detect the levels of relevant proteins.

Results: We found that salivary IgA content was significantly decreased in patients with ASD and had a significant ASD diagnostic value. The salivary IgA content also decreased in VPA mice and was significantly correlated with autistic-like behaviors among them. The mRNA and protein levels of the polymeric immunoglobulin receptor (Pigr) were downregulated in the submandibular glands of VPA mice and the Pigr mRNA level was positively correlated with mouse salivary IgA content. HSG cells treated with ASD-related Streptococci had reduced PIGR protein level.

Conclusion: Therefore, protective IgA levels were reduced in the saliva of individuals with ASD, which correlated with the bacteria-induced downregulation of Pigr in salivary glands. This study suggests a new direction for ASD diagnosis and prevention of oral diseases in ASD cohorts and provides evidence for the ASD mucosal immunophenotype in the oral cavity.
A Critical Theoretical Approach to Cancer Disparities: Breast Cancer and the Social Determinants of Health
Authors: Gehlert Sarah , Hudson Darrell , Sacks Tina
Published: May 2021

Breast cancer is the most commonly experienced cancer among women. Its high rates of incidence and survival mean that a number of women will live it for periods of their lifetimes. Group differences in breast cancer incidence and mortality occur by race and ethnicity. For example, while white women are slightly more likely to be diagnosed with breast cancer, Black women are 40% more likely to die from the disease. In this article, rather than focusing the discussion on individual-level factors like health behaviors that have the potential to blame Black women and those living in poverty for their conditions, we view breast cancer disparities through the lens of Critical Race Theory, taking a historical perspective. This allows us to delve beyond individual risk factors to explore social determinants of breast cancer disparities at the population level, paying special attention to the myriad ways in which social factors, notably views of race and discriminatory public policies, over time have contributed to the disproportionate breast cancer mortality experienced by Black women. We suggest ways of addressing breast cancer disparities, including methods of training healthcare professionals and public policy directions, that include rather than marginalize Black and lower socioeconomic status women.
Empirical Examination on the Drivers of the U.S. Equity Returns in the During the COVID-19 Crisis
Authors: Wang Qing , Bai Mo , Huang Mai
Published: May 2021

This study investigates the drivers of the Standard & Poor's (S&P) 500 equity returns during the COVID-19 crisis era. The paper considers various determinants of the equity returns from December 31, 2019, to February 19, 2021. It is observed that the United States Dollar (USD) and the volatility indices (VIX) negatively affect the S&P 500 equity returns. However, the newspaper-based infectious disease “equity market volatility tracker” is positively associated with the stock market returns. These results are robust to consider both the ordinary least squares (OLS) and the least angle regression (LARS) estimators.
Attention Enhancement for Exoskeleton-Assisted Hand Rehabilitation Using Fingertip Haptic Stimulation
Authors: Li Min , Chen Jiazhou , He Guoying , Cui Lei , Chen Chaoyang , Secco Emanuele Lindo , Yao Wei , Xie Jun , Xu Guanghua , Wurdemann Helge
Published: May 2021

Active enrollment in rehabilitation training yields better treatment outcomes. This paper introduces an exoskeleton-assisted hand rehabilitation system. It is the first attempt to combine fingertip cutaneous haptic stimulation with exoskeleton-assisted hand rehabilitation for training participation enhancement. For the first time, soft material 3D printing techniques are adopted to make soft pneumatic fingertip haptic feedback actuators to achieve cheaper and faster iterations of prototype designs with consistent quality. The fingertip haptic stimulation is synchronized with the motion of our hand exoskeleton. The contact force of the fingertips resulted from a virtual interaction with a glass of water was based on data collected from normal hand motions to grasp a glass of water. System characterization experiments were conducted and exoskeleton-assisted hand motion with and without the fingertip cutaneous haptic stimulation were compared in an experiment involving healthy human subjects. Users’ attention levels were monitored in the motion control process using a Brainlink EEG-recording device and software. The results of characterization experiments show that our created haptic actuators are lightweight (6.8 ± 0.23 g each with a PLA fixture and Velcro) and their performance is consistent and stable with small hysteresis. The user study experimental results show that participants had significantly higher attention levels with additional haptic stimulations compared to when only the exoskeleton was deployed; heavier stimulated grasping weight (a 300 g glass) was associated with significantly higher attention levels of the participants compared to when lighter stimulated grasping weight (a 150 g glass) was applied. We conclude that haptic stimulations increase the involvement level of human subjects during exoskeleton-assisted hand exercises. Potentially, the proposed exoskeleton-assisted hand rehabilitation with fingertip stimulation may better attract user’s attention during treatment.
A Combined “Hanging Liver Maneuver” and “Intrahepatic Extra-Glissonian Approach” for Anatomical Right Hepatectomy: Technique Standardization, Results, and Correlation With Portal Pedicle Anatomy
Authors: Makdissi Fabio Ferrari , Mattos Bruno Vinicius Hortences de , Kruger Jaime Arthur Pirola , Jeismann Vagner Birk , Coelho Fabricio Ferreira , Herman Paulo
Published: May 2021

Background: The hanging liver maneuver and intrahepatic extra-Glissonian approach are distinct modalities to facilitate safe anatomical liver resections. This study reports a standardized combination of these techniques focusing on safety, results and correlation with portal pedicle anatomy in oncological patients.

Method: Combined hanging liver maneuver and intrahepatic extra-Glissonian approach for anatomic right hepatectomy was described stepwise. Portal pedicle anatomy was correlated with the Glissonian approach failure and complications. Clinical characteristics of patients, perioperative outcomes, short and long-term survival rates were analyzed.

Results: Thirty colorectal liver metastases patients submitted to the combined approach were evaluated. Anatomical variations of the right portal pedicle were present in 26.6%. Hanging liver maneuver was feasible in 100%, and Glissonian approach in 96.7% despite portal pedicle variations. Mean operative time was 326 min. Mean blood loss was 507 ml. Mean hospital stay was 8 days. There was no 90-day operative mortality and no significant morbidity. Oncological surgical margins were free. Overall and disease-free 5-year survival were 59 and 37%.

Conclusion: Regardless of frequent anatomical variations of the right portal pedicle, the hanging liver maneuver, and intrahepatic extra-Glissonian approach can be combined, being useful for anatomical right hepatectomies in a safe and reproducible way in most patients.
Pharmacoeconomic Analysis of Heartworm Preventive Compliance and Revenue in Veterinary Practices in the United States
Authors: Mwacalimba Kennedy , Amodie Deborah , Swisher Lisa , Moldavchuk Marina , Brennan Christopher , Walther Claire , Bowman Kelly
Published: May 2021

Background: Heartworm disease (HWD) is a potentially fatal condition caused by the nematode Dirofilaria immitis. It is endemic in North America, and the American Heartworm Society recommends that owned dogs be on a Food and Drug Administration-approved HWD preventive year-round. The objective of this study was to compare the 12-month HWD preventive purchase compliance rates of injectable moxidectin (ProHeart® 6) and the dose equivalent in monthly HWD preventives and their associated economic value to the veterinary hospital.

Methods: This study used retrospective anonymized transactional data of 7,926,392 unique dogs from 3,737 companion animal practices across the US for the period 2014–2017. Compliance was defined using American Heartworm Society guidelines. Comparisons were purchases of a 6-month moxidectin injection or six doses of any monthly HWD or HWD combination preventive product, tracked for the next preventive purchase 5–7 months later. Total revenue, HWD prevention cost, 12-month repurchase compliance, and patient retention were calculated. Data were expressed on an annualized basis. Compliance comparisons were calculated based on proportion analysis with the SAS ProbNorm function (SAS 9.4, Cary, NC), using a two-sided t-test, at the 5% level of significance (P < 0.05).

Results: At 51.7%, annual compliance with injectable moxidectin was higher than the dose equivalent in monthly HWD preventives, which was 24.4% (P = 0.0001). Eighty-five percent of patients on injectable moxidectin recorded additional transactions during the first visit (average invoice of $161), compared with only 55% of pet owners who purchased monthly HWD prevention (average invoice $141) or monthly HWD combination (average invoice of $171). The average costs of 6 months of HWD preventives were as follows: injectable moxidectin, $48 (29.7% of the total visit invoice); monthly HWD prevention, $45 (31.0% of the total invoice); and monthly HWD combination, 95 (55.6% of the total visit invoice). Finally, dogs receiving injectable moxidectin had a higher proportion of patients with repeat injections within 12 months between 2014 and 2017, with 68% retention rate after 4 years. In comparison, the six-dose monthly HWD cohort retention rate dropped to 55% by 2017.

Conclusions: Dogs receiving injectable moxidectin had higher HWD preventive compliance, generated more practice revenue, and had a higher rate of practice retention compared with monthly HWD products.
Evaluation of Intra-Articular Amikacin Administration in an Equine Non-inflammatory Joint Model to Identify Effective Bactericidal Concentrations While Minimizing Cytotoxicity
Authors: Pezzanite Lynn , Chow Lyndah , Hendrickson Dean , Gustafson Daniel L. , Russell Moore A , Stoneback Jason , Griffenhagen Gregg M. , Piquini Gabriella , Phillips Jennifer , Lunghofer Paul , Dow Steven , Goodrich Laurie R.
Published: May 2021

Septic arthritis causes significant morbidity and mortality in veterinary and human clinical practice and is increasingly complicated by multidrug-resistant infections. Intra-articular (IA) antibiotic administration achieves high local drug concentrations but is considered off-label usage, and appropriate doses have not been defined. Using an equine joint model, we investigated the effects of amikacin injected at three different doses (500, 125, and 31.25 mg) on the immune and cartilage responses in tibiotarsal joints. Synovial fluid (SF) was sampled at multiple time points over 24 h, the cell counts determined, and amikacin concentrations measured by liquid chromatography-mass spectrometry. Cytokine concentrations and collagen degradation products in SF were measured by ELISA and multiplex immunoassays. The mean amikacin concentrations in SF were greater than or equal to the minimum inhibitory concentration (MIC) (0.004 mg/ml) for most common equine joint pathogens at all time points tested to 24 h for all three amikacin doses evaluated. The inflammatory cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) increased significantly in SF in the highest amikacin dose group, despite the fact that increases in SF cell counts were not observed. Similarly, the biomarkers of cartilage type II collagen cleavage (C2C and C12C) were increased in SF following amikacin injection. Mechanistically, we further demonstrated using in vitro studies that chondrocytes and synoviocytes killed by exposure to amikacin underwent apoptotic cell death and were phagocytosed by macrophages in a non-inflammatory process resembling efferocytosis. Neutrophils and T cells were susceptible to amikacin cytotoxicity at clinically relevant doses, which may result in blunting of cellular inflammatory responses in SF and account for the lack of increase in total nucleated cell counts following amikacin injection. In summary, decisions on whether to inject cytotoxic antibiotics such as aminoglycosides intra-articularly and what doses to use should take into account the potential harm that antibiotics may cause and consider lower doses than those previously reported in equine practice.
Informacja pragmatyczna w słowniku ortoepicznym. Stan obecny i potrzeby
Authors: Zdunkiewicz-Jedynak Dorota
Published: May 2021

For language users, language is a certain continuum along which the
boundary between semantics and pragmatics blurs and where phenomena from
both planes are related to the concept of language norm (linguistic standard,
literary norm) and the proper use of linguistic units is not limited to complying
with the rules of grammar or respecting their strict meaning. An important
component of the proper use of language is the pragmatically adequate selection
of the available language means. The question of a methodological nature is the
way in which pragmatic information is introduced to such lexicons. Traditionally,
usage labels are used for this purpose. Sometimes, however, in order for an
orthoepic dictionary to really fulfi l its function, pragmatic information should be
presented in a more descriptive, narrative manner. The pragmatic aspect of the
language norm can be described in a dictionary not only in the “pragmatic tabs”
of specifi c entries but it can also be captured comprehensively, as a “theoretical
article” relating either to the pragmatic properties of certain word categories
(e.g. diminutives, children’s vocabulary, metaphors relating to people).
Keywords: pragmatics – orthoepic dictionary – language norm – correctness
Yield Comparisons between Cotton Variety Xin Nong Mian 1 and Its Transgenic ScALDH21 Lines under Different Water Deficiencies in a Desert-Oasis Ecotone
Authors: Yang Honglan , Bozorov Tohir A. , Chen Xiaoping , Zhang Dawei , Wang Jiancheng , Li Xiaoshuang , Gui Dongwei , Qi Zhiming , Zhang Daoyuan
Published: May 2021

Water scarcity is the major limiting factor for oasis-desert agricultural production of cotton. It is necessary to improve cotton for drought tolerance and minimize drought-related crop losses, and the transgenic approach is efficient for cotton improvement. In order to evaluate the value of ScALDH21 transgenic cotton (G. hirsutum L.), it was tested in the main cotton region of south Xinjiang, in an environment of extreme drought around the desert. Transgenic cotton, overexpressing aldehyde dehydrogenase gene (ScALDH21) from the desiccation-tolerant moss Syntrichia caninervis in cotton variety Xin Nong Mian 1, was field-tested under six treatments based on three irrigation schedules and two irrigation levels (full (FI) and deficit (DI) irrigation) as follows: root zone model-simulated forecast irrigation (F) (FFI and FDI), soil moisture sensor-based irrigation (S) (SFI and SDI), and flood irrigation based on experience estimates (E) (EFI and EDI) to evaluate growth and yield performances. The results revealed that plant height and leaf area increased significantly in ScALDH21-transgenic cotton genotypes under all treatments. Physiological parameters such as chlorophyll content, net photosynthesis rate, and instantaneous water use efficiency were not significantly highly in transgenic lines compared to non-transgenic plants (NT). However, transgenic lines showed significantly improved yield and superior fiber quality than NT plants regardless of irrigation. The results demonstrate that ScALDH21-transgenic lines were excellent compared to NT plants under different water deficiency conditions. The study also provides guidelines for optimal irrigation protocol and minimum water requirements for the use of the ScALDH21-transgenic cotton lines in arid zones.