bluuebunny/crossref_metadata_2025 huggingface dataset:
The voice of the consumer: A survey of consumer priorities to inform knowledge translation among Veterans who use mobility assistive technology
Authors: Quinby Eleanor , McKernan Gina , Eckstein Stacy , Joseph James , Dicianno Brad E. , Cooper Rory A.
Published: June 2021

LAY SUMMARY

Mobility assistive technology (AT) can improve the lives of people with disabilities by helping them get around in their communities. Today, over 23.9 million Americans use a wheelchair or assistive device, and over 85,000 wheelchairs, scooters, or other mobility devices are provided to Veterans each year. In order to find out how people learn about AT to improve efforts to disseminate information about AT, a survey of people who use mobility AT was conducted. The majority of people who completed the survey were Veterans (82%). It was determined that these people most often learned about AT through other users and/or from Veterans and the Internet, and that some people wish to receive information in other ways. Researchers can use these findings to better reach the people who could benefit from the new mobility AT they are creating.
A consumer assessment of women who use wheelchairs
Authors: Greenhalgh Mark , Rigot Stephanie , Eckstein Stacy , Joseph James , Cooper Rosemarie M. , Cooper Rory A.
Published: June 2021

LAY SUMMARY

Female Veterans and female athletes with disabilities express concerns with mobility devices that are male-centric and do not address their unique needs. It is important that the needs of women are given the same attention as those of men. The following study asked groups of women who use wheelchairs or scooters, including Veterans and athletes, about their experiences. Twenty-four women, recruited from two sporting events for Veterans with disabilities, were asked to fill out a survey and participate in a focus group where they would discuss their views on mobility aids and related services. There were four major themes women often mentioned when they talked about using their mobility aids: usability (how they like using it), service delivery (how they get help with it), well-being (how they feel), and design (how it looks and works). Participants were concerned about the ability to adjust their device to their needs, how people obtained a device, and how they felt about using the device. Female wheelchair and scooter users recommended several changes to mobility aids that would improve the devices and improve the lives of women who use them.
“A Dramaturgical Chimera”: Judith Thompson, Urjo Kareda, and the Politics of Playwright-Dramaturg Negotiations
Authors: Riley Jessica
Published: June 2021

Dans cet article, Jessica Riley part de recherches qu’elle a menées dans les archives pour explorer l’effet complexe que peuvent avoir le genre, le pouvoir et le privilège sur les négociations entre dramaturges et conseillers ou conseillères dramaturgiques. S’appuyant dans son analyse sur des documents qui portent sur le travail dramaturgique sur la pièce White Biting Dog de Judith Thompson, Riley souligne des révisions importantes apportées par la dramaturge en réponse aux commentaires et aux questions de son conseiller dramaturgique, Urjo Kareda. En mettant au jour les dynamiques de pouvoir et de résistance axées sur le genre dans ces négociations, Riley montre la résilience et la capacité d’agir de Thompson tout en reconnaissant que tous les dramaturges ne sont pas en mesure de réagir au contrôle dramaturgique comme Thompson l’a fait, au bénéfice de sa pièce et de sa carrière.
Clinicopathologic Characteristics and Treatment Outcomes of Rectal Gastrointestinal Stromal Tumors: A Retrospective Study
Authors: Li Chujun , Lu Yi , Chen Junrong , Chen Honglei , Sun Jiachen , Kong Xianhe , Zhong Weijie , Li Chujun
Published: May 2021

Background and Study Aims: To investigate the clinicopathologic characteristics, surgical and imatinib management and long-term follow-up outcomes of the rectal gastrointestinal stromal tumors (GISTs).
Patients and Methods: Consecutive patients with rectal GISTs admitted to our center (from January 2013 to June 2018) were chosen. Their history information was viewed, and the follow-up results were obtained by phone or medical records.
Results: Forty-nine patients (32 males and 17 females) were identified, with a median age of 59 years, and 36 patients received surgery. Most (46 patients, 93.9%) of the tumor were located within 6 cm from the anal verge, 18 patients (36.7%) had very low or low risk, and 31 patients (63.3%) had intermediate or high risk. Four kinds of surgery approach were applied in our center: trans-abdominal (8 patients, 22.2%), trans-anal/trans-perineal (15 patients, 41.7%), trans-sacral (12 patients, 33.3%) and abdominoperineal (1 patient, 2.8%). The complication is low and the mortality related to surgery is 0%. After a median follow-up of 705 days (ranged from 48 days to 1677 days), 3 patients (8.33%) were found to have a recurrence.
Conclusion: Trans-anal/trans-perineal and trans-sacral surgery were more commonly used in our study, and for now, the recurrence rate had no difference, but a longer time for follow-up is needed.
ESTUDOS SOBRE O ENSINO E APRENDIZAGEM DE CONCEITOS EM ELETROQUÍMICA: UMA REVISÃO
Authors: Vieira Danielle de Oliveira , Pereira Braga Marcel Bruno , Ribeiro Passos Raimundo , De Aquino Farias Sidilene
Published: June 2021

O presente estudo objetivou mapear e classificar, nas pesquisas que abordam o ensino e aprendizagem de conceitos eletroquímicos, aspectos metodológicos, base teórica e principais contribuições para a área de Ensino de Química no Brasil. Para isso, utilizou-se os seguintes procedimentos de coleta de dados: (1) seleção dos artigos; (2) triagem a partir da leitura integral dos artigos; (3) análise dos artigos baseada nas seguintes categorias de análise: Aspectos Metodológicos; Base Teórica e Resultados das Pesquisas. Foram selecionados 19 artigos entre quatro periódicos selecionados, cujos resultados obtidos revelam que a maioria das pesquisas é empírica, com abordagem qualitativa e prioriza o Ensino Médio e Ensino Superior. Em relação às Bases Teóricas, as pesquisas pautam-se em teorias Cognitivistas - Teoria da Aprendizagem Significativa e Teoria Sociocultural, fundamentam-se também no campo da Didática das Ciências, sendo predominante a experimentação (demonstrativa, investigativa e/ou problematizadora). Por fim, os Resultados das Pesquisas apontam as dificuldades de aprendizagem e estratégias remediativas das mesmas, destacando-se que a utilização de estratégias remediativas perpassa pela superação de visões simplistas das concepções de ciências, da natureza da ciência e de concepções de ensino e aprendizagem, tanto na formação inicial e continuada de professores de Ciências.
Enhanced biomaterials: systematic review of alternatives to supplement spine fusion including silicon nitride, bioactive glass, amino peptide bone graft, and tantalum
Authors: Fiani Brian , Jarrah Ryan , Shields Jennifer , Sekhon Manraj
Published: June 2021

OBJECTIVE

Spinal fusions are among the most common and effective spinal surgical practices; however, the current model presents some cost and safety concerns within the patient population. Therefore, enhanced biomaterials have been presented to be an innovative yet underutilized tool to supplement the success of spinal fusion surgery. Herein, the authors discuss these biomaterials, their compositions, clinical outcomes, and cost analysis through a systematic review of the literature to date.

METHODS

This systematic review was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria and guidelines. Article selection was performed using the PubMed electronic bibliographic databases. The search yielded 1168 articles that were assessed and filtered for relevance by the four authors. Following the screening of titles and abstracts, 62 articles were deemed significant enough for final selection.

RESULTS

To date, silicon nitride, bioactive glass, amino peptide bone grafts, and tantalum are all biomaterials that could have significant roles in supporting spinal fusion. Their unique compositions allow them to be biocompatible in the spine, and their mechanisms of action stimulate osteoblast formation and support fusion success. Moreover, these biomaterials also present positive clinical and cost outcomes that support their application in spinal procedures. However, further studies with longer follow-ups are necessary to fully understand these biomaterials prior to their incorporation in mainstream spinal practice.

CONCLUSIONS

The combination of their positive clinical outcomes, biocompatibility, and cost-effectiveness makes these biomaterials valuable, innovative, and effective treatment modalities that could revolutionize the current model of spinal fusion.
Impact of surgeon rhBMP-2 cost awareness on complication rates and health system costs for spinal arthrodesis
Authors: McGrath Margaret , Feroze Abdullah H. , Nistal Dominic , Robinson Emily , Saigal Rajiv
Published: June 2021

OBJECTIVE

Recombinant human bone morphogenetic protein–2 (rhBMP-2) is used in spinal arthrodesis procedures to enhance bony fusion. Research has suggested that it is the most cost-effective fusion enhancer, but there are significant upfront costs for the healthcare system. The primary objective of this study was to determine whether intraoperative dosing and corresponding costs changed with surgeon cost awareness. The secondary objective was to describe surgical complications before and after surgeon awareness of rhBMP-2 cost.

METHODS

A retrospective medical record review was conducted to identify patients who underwent spinal arthrodesis procedures performed by a single surgeon, supplemented with rhBMP-2, from June 2016 to June 2018. Collected data included rhBMP-2 dosage, rhBMP-2 list price, and surgical complications. Expected Medicare reimbursement was calculated. Data were analyzed before and after surgeon awareness of rhBMP-2 cost.

RESULTS

Forty-eight procedures were performed using rhBMP-2, 16 before and 32 after surgeon cost awareness. Prior to cost awareness, the most frequent rhBMP-2 dosage level was x-small (38.9%, n = 7), followed by large (27.8%, n = 5) and small (22.2%, n = 4). After cost awareness, the most frequent rhBMP-2 dosage was xx-small (56.8%, n = 21), followed by x-small (21.6%, n = 8) and large (13.5%, n = 5). The rhBMP-2 average cost per surgery was $4116.56 prior to surgeon cost awareness versus $2268.38 after. Two complications were observed in the pre—cost awareness surgical group; 2 complications were observed in the post—cost awareness surgical group.

CONCLUSIONS

Surgeon awareness of rhBMP-2 cost resulted in use of smaller rhBMP-2 doses, decreased rhBMP-2 cost per surgery, and decreased overall hospital admission charges, without a detectable increase in surgical complications.
Investigating the efficacy of allograft cellular bone matrix for spinal fusion: a systematic review of the literature
Authors: Diaz Ryan R. , Savardekar Amey R. , Brougham Jared R. , Terrell Danielle , Sin Anthony
Published: June 2021

OBJECTIVE

The use of allograft cellular bone matrices (ACBMs) in spinal fusion has expanded rapidly over the last decade. Despite little objective data on its effectiveness, ACBM use has replaced the use of traditional autograft techniques, namely iliac crest bone graft (ICBG), in many centers.

METHODS

In accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, a systematic review was conducted of the PubMed, Cochrane Library, Scopus, and Web of Science databases of English-language articles over the time period from January 2001 to December 2020 to objectively assess the effectiveness of ACBMs, with an emphasis on the level of industry involvement in the current body of literature.

RESULTS

Limited animal studies (n = 5) demonstrate the efficacy of ACBMs in spinal fusion, with either equivalent or increased rates of fusion compared to autograft. Clinical human studies utilizing ACBMs as bone graft expanders or bone graft substitutes (n = 5 for the cervical spine and n = 8 for the lumbar spine) demonstrate the safety of ACBMs in spinal fusion, but fail to provide conclusive level I, II, or III evidence for its efficacy. Additionally, human studies are plagued with several limiting factors, such as small sample size, lack of prospective design, lack of randomization, absence of standardized assessment of fusion, and presence of industry support/relevant conflict of interest.

CONCLUSIONS

There exist very few objective, unbiased human clinical studies demonstrating ACBM effectiveness or superiority in spinal fusion. Impartial, well-designed prospective studies are needed to offer evidence-based best practices to patients in this domain.
New and promising immune oncology drugs combinations
Authors: Volkov N.М.
Published: May 2021

Given that no new immunotherapeutic drugs proved to be at least as effective as approved CTLA-4 and PD-1/PD-L1 inhibitors during last years the focus of further immuno oncology (IO)development has shifted to the research on different drug combinations. Most of new immunotherapeutics are studied in combinations with PD-1/PD-L1 inhibitors. This paper reviews most perspective targets for therapeutic manipulations currently studied in combinations with immune check-point inhibitors, such as Tim-3, LAG-3, TIGIT, OX-40, 4-1BB, STING, TGF-β, as well as some metabolic pathways. Also the principles of individualized biology-tailored approaches to IO drugs combining are discussed.
A SYSTEMATIC REVIEW METHOD FOR SECURITY ANALYSIS OF INTERNET OF THINGS ON HONEYPOT DETECTION
Authors: Yuswanto Andrie , Wibowo Budi
Published: May 2021

A very significant increase in the spread of malware has resulted in malware analysis. A recent approach to using the internet of things has been put forward by many researchers. Iot tool learning approaches as a more effective and efficient approach to dealing with malware compared to conventional approaches. At the same time, the researchers transformed the honeypot as a device capable of gathering malware information. The honeypot is designed as a malware trap and is stored on the provided system. Then log the managed events and gather information about the activity and identity of the attacker. This paper aims to use a honeypot in machine learning to deal with malware The Systematic Literature Review (SLR) method was used to identify 207. Then 10 papers were selected to be investigated based on inclusion and exclusion criteria. . The technique used by most researchers is to utilize the available honeypot dataset. Meanwhile, based on the type of malware being analyzed, honeypot in machine learning is mostly used to collect IoT-based malware.
The clinical features of COVID - 19 in a group of Iraqi patients: A record review
Authors: Dawood Haider , Hwayyiz Ayad , Ibrahim Ibrahim , Abdul Rahman Imad
Published: May 2021

Background: The number of coronavirus infection cases has increased rapidly since early reports in the December 2019 in China. But data on the clinical features of infected peoples is variable from one country to the other.
Objective: Studying clinical features of patients with a positive RT PCR COVID – 19, in a group of Iraqi patients.
Results: The study included 200 patients with 133 (66.5%) males and 67 (33.5%) females, and age range of 14- 89 years, with mean age 46.4 years. A history of contact with a COVID -19 positive case was found in 80 patients (40%), Ischemic Heart Disease in 11 patients (5.5%), hypertension 34 (17%), diabetes mellitus 36 patients (18%). The most frequently seen age group was between 21-39 years (76 patients - 38%). The most frequently seen symptoms were fever 76.5% and generalized weakness 73%. A statistically significant association was found between age and dyspnea (p = 0.014) and also diarrhea (p = 0.035), as well as between gender and rhinorrhea (p = 0.08) and nausea and/ or vomiting (p = 0.005).
Patients and Methods: This is a record review study of 200 patients with a confirmed COVID - 19, conducted in Al Imamain Al Kadhimain Medical City from 1 May to 30 August 2020, the diagnosis of patients during this period. Data about demographic and the clinical characteristics have been recorded.
Missed symptoms of behjet’s disease
Authors: Altaha Lama H.
Published: May 2021

Abstract
Objectives: Behçet's disease is a systemic chronic proinflammatory vascular disease .this study wants to describe more details of patients with Behçet’s disease in iraq.
Methods: Any patient with suspected or diagnosed  Behçet’s  disease attending centre of dermatology/behjet unit , 2017-  2018.
A total 47 patients ,Full history and examination were taken.
Percentage of complains were calculated.
Results: 37 were females and 10 were males , Age of patients ranged from (11-63) years.Pethargy test was negative in 13 patients , positive in 15 ,21 had negative family history and 9 had positive .
They complain from Malaise , oral ulcer, genital ulcer, unexplained fever ,20 symptoms began from childhood ,decreased hearing,eye complain, dysphagia , dyspnea ,headache ,  memory problems, depression , muscle contraction, peripheral paresthesia , joint complains, sleep disturbances and  renal problems.
Conclusion:  describes new symptoms can help in diagnosis of behjet’s disease .
YOUTUBE PLATFORMUNDAKİ “… İÇİN ÇAL / SÖYLE / OKU” ETİKETLİ VİDEO İÇERİKLERİ ÜZERİNE FOLKLORİK BİR İNCELEME
Authors: DİNÇ Mustafa
Published: May 2021

Kitle iletişim araçları içerisinde yediden yetmişe herkesin yoğun bir temas hâlinde olduğu internet, ortaya çıktığı temel amaç olan askeri haber alma vasfından oldukça farklılaşarak günümüzde bireylerin günlük rutinleri içerisinde en çok vakit geçirdikleri, kendi duygu ve düşünce dünyalarına uygun çeşitli içerikleri ürettikleri, paylaştıkları veya takip ettikleri bir sosyal ortam hâline gelmiştir. Sosyal medya adı verilen internet platformları aracılığıyla meydana gelen bu dönüşüm yeni medya ortamlarını takip eden kitlelerin beğenileri, ilgileri, eğilimleri doğrultusunda kısa zaman içerisinde birbirinden farklı akımların ortaya çıkmasını sağlamıştır. Genellikle Amerika ve Avrupalı kullanıcılar arasında ortaya çıkan ve benzer kurgudaki fotoğraf ve videoların paylaşılmasına dayanan bu akımlardan biri de öncülü 2002 de Kıta Amerika’sında görülen; Türkiye sahasında ise 2009 yılından itibaren “…İçin Çal/ Söyle/ Oku” etiketleri ile yaygınlaşan video içerikleridir. YouTube başta olmak üzere çeşitli platformlarda paylaşılan bu etikete sahip içerikler zamanla pek çok konu ve amaç doğrultusunda çeşitlenmiş ve çok farklı işlevleri yerine getirir bir hâl almıştır.

Çalışmada, internet ve sosyal medya kavramları üzerinde kısaca durulmasının ardından bu ortamlarda Türkiye sahası kullanıcılar tarafından ilgiyle karşılanan ve 2020 yılının ikinci yarısına değin YouTube platformunda paylaşıldığı tespit edilen 300’ü aşkın “…İçin Çal/ Söyle/ Oku” etiketli video içeriği, isim, yüklenme tarihi, süre, müzikal-sözel-görsel doku, yayıncı, görüntülenme sayısı, konu-amaç ve link bilgileri ile fişlenerek içerik çözümlemesi yöntemi ile tek tek ele alınmış, ayrıca bunların ortak noktaları ve farklılıkları üzerinde durularak bu içeriklerin işlevleri yorumlanmıştır. Bu doğrultuda, başlangıç olarak sosyal sorumluluk düşüncesi ile oluşturulan içeriklerin, kutlama, tanıtım-reklam, protesto, mesleki-kültürel birlik beraberlik gibi amaçlarla da hazırlanarak paylaşıldıkları ve zamanla folklorun işlevleri ile orantılı olarak eğlence, ticari-ekonomik, sosyal, kültürel, eğitimsel ve protesto yönlerinden bazı işlevler kazandıkları ve değişen şartlar altında, güncel olaylara uygun biçimde yeni konu, işlev ve bağlamlarla çeşitlenerek yaygınlaştıkları tespit edilmiştir.
BEHCETÜ’L-HADÂİK’TA İKİLEMELER
Authors: BEYİTOĞLU Yahya Kemal
Published: May 2021

Türkçenin tarih boyunca çok geniş coğrafyalara yayılmış ve çok farklı kültürel kaynaklardan beslenmiş olması, söz varlığı açısından oldukça zengin eserler yazılmasını sağlamıştır. Bu eserlerden biri de şimdiye değin Anadolu sahasında yazıldığı tespit edilebilen en eski telif eser olan Behcetü’l-Hadâik’tır. Eser, aynı zamanda taşıdığı dil özellikleri bakımından karışık dilli eserler arasında sayılmaktadır. Bugüne kadar eserin hem neşri hem de dil özellikleri konusunda pek çok çalışma yapılmıştır. Ancak doğrudan eserde geçen ikilemeleri inceleyen bir çalışma bulunmamaktadır. İkilemeler, genel olarak eş, yakın veya zıt anlamlı kelimelerin tekrarıyla oluşan yapılar olarak tanımlanmaktadır. Bununla birlikte ikilemeler, Türkçenin söz varlığı yönünden zenginliğini ortaya koyan en önemli unsurlarından biridir.

Bu çalışmada, Behcetü’l-Hadâik’ta tespit edilen 95 ikileme anlamsal kuruluşlarına, kelime türlerine ve farklı kuruluş yapılarına göre sınıflandırılarak incelenmiştir.
Musculoskeletal ultrasound for 3D bone modeling: A preliminary study applied to lumbar vertebra
Authors: Forbes A. , Cantin V. , Develle Y. , Dubé Y. , Bertrand-Grenier A. , Ménard-Lebel C. , Sobczak S.
Published: June 2021

BACKGROUND: There is no non-invasive in vivo method to assess intervertebral kinematics. Current kinematics models are based on in vitro bone reconstructions from computed tomography (CT)-scan imaging, fluoroscopy and MRIs, which are either expensive or deleterious for human tissues. Musculoskeletal ultrasound is an accessible, easy to use and cost-effective device that allows high-resolution, real-time imaging of bone structure. OBJECTIVE: The aim of this preliminary study was to compare the concordance of 3D bone modeling of lumbar vertebrae between CT-scan and ultrasound imaging and to study the intra and inter-reliability of distances measured on 3D ultrasound bone models. METHODS: CT-scan, ultrasound, and in situ data of five lumbar vertebrae from the same human specimen were used. All vertebrae were scanned by tomography and a new musculoskeletal ultrasound procedure. Then, 3D bone modeling was created from both CT-scan and ultrasound image data set. Distances between anatomical bones landmarks were measured on the 3D models and compared to in situ measurements.
Dynamic fixation using rigid tape in rehabilitation after surgery of terrible triad injury of the elbow: A randomized trial
Authors: Du Shenxing , Wei Lihong , He Bangjian , Fang Zhen , Zhou Eryuan , Ma Xiaoxiao , Li Ju
Published: June 2021

OBJECTIVE: The aim of the study was to identify the efficacy of dynamic fixation using rigid tape (RT) in rehabilitation after surgery of terrible triad injury of the elbow (TTIE). METHODS: Sixty patients who underwent surgery of TTIE were equally randomly divided into RT group and hinged external fixation brace (HEFB) group. Dynamic fixations were applied for 8 weeks. General rehabilitation programs were performed for 3 months, 5 times a week. Follow-up (FU) was at six months. Main outcomes included pain (Visual Analogue Scale, VAS), muscle strength, range of motion (ROM), Elbow Function (Mayo Elbow Performance Index, MEPI), Quality of Life (QOL) (Short Form 36 Questionnaire, SF-36). RESULTS: There were significant time x group interactions for pain, ROM, MEPI, SF-36 (all p= 0.000), which demonstrated positive efficacy of both the two interventions. Difference at each time-point (except for baseline) of pain and ROM between the two groups was statistically significant (all p< 0.05). Some differences between the two groups were not statistically significant which at 14d on MEPI (p= 0.108) and at 21d (p= 0.259) and FU (p= 0.402) on QOL. Moreover, the increased muscle strength at each time-point had no statistically significant difference between the two groups (all p> 0.05). CONCLUSIONS: Both RT and HEFB could significantly improve the postoperative functional outcomes of the TTIE. However, early rehabilitation intervention could increase pain, which affected the corresponding function (MEPI) and QOL. Note that this kind of impact was short-term and reversible. The muscle strength and ROM were not affected by the increased severe pain, maintaining a trend of improvement. In addition, the subjects in the RT group improved faster and more efficiently and had better results with pain, ROM, MEPI, and QOL compared to the subjects in the HEFB group.
Effects of transcutaneous electrical nerve stimulation and instrument-assisted soft tissue mobilization combined treatment on chronic low back pain: A randomized controlled trial
Authors: Kim Young Kyun , Cho Sung Yeon , Lee Kun Ho
Published: June 2021

BACKGROUND: Transcutaneous electrical nerve stimulation (TENS) for chronic low back pain (CLBP) requires a treatment period of ⩾ 6 weeks to decrease pain and disability and is ineffective as sole treatment. Instrument-assisted soft tissue mobilization (IASTM) has rapid effects in musculoskeletal disorders. OBJECTIVE: This study aimed to investigate the effects of a 3-week combined TENS and IASTM treatment (TICT) on CLBP. METHODS: Thirty-two young men with CLBP were randomly divided into the TICT and control groups (n= 16 each). Patients were evaluated with the visual analog (VAS) and face pain-rating scales (FPRS) for pain, the Oswestry Disability Index (ODI) and passive straight leg raise (PSLR) test for flexibility, and the supine bridge test (SBT) for endurance before and after the treatment course. The TICT group received TICT on the lower back, glutes, and hamstrings, six times in 3 weeks. RESULTS: Group, time, and group × time interaction effects on pain were significant (VAS and FPRS, all p< 0.001). Group × time interaction (ODI, p< 0.001; PSLR, p< 0.05; SBT, p< 0.01) and group (ODI, p< 0.05) and time main effects (ODI, p< 0.001; PSLR, p< 0.01; SBT, p< 0.001) on motor function were significant. CONCLUSION: Thus, short-term TICT decreased pain level and increased motor function in CLBP patients, yet further investigation is needed on different age and gender groups.
Evaluation of a 92 multiplex protein panel in detection of colorectal cancer and high-risk adenoma in 784 symptomatic individuals
Authors: Rasmussen Louise , Nielsen Hans Jørgen , Christensen Ib Jarle
Published: June 2021

BACKGROUND: Blood-based protein biomarkers for detection of colorectal cancer (CRC) have been submitted to intense research to improve the full potential in screening for CRC. OBJECTIVE: The aim was to explore the diagnostic performance of 92 proteins related to inflammation and carcinogenesis in detection of CRC or precancerous lesions. METHODS: Blood-samples were collected from 4,698 individuals undergoing colonoscopy. An explorative unmatched case-control study was designed with 294 cases (individuals with CRC or high-risk colorectal adenoma) and 490 controls (individuals with low-risk colorectal adenoma, non-malignant findings or clean colorectum at colonoscopy). Protein profiling was performed by multiplex proximity extension assay. Statistical analyses were performed as univariate and multivariate logistic regression analyses. RESULTS: Univariably, CSF-1, MMP12 and IL8 demonstrated superior performance in discrimination of individuals with CRC. Recurrently, IL8 was included as contributor in majority of multivariate models discriminating individuals with CRC. The multivariate evaluation in discrimination of individuals with CRC demonstrated AUC=ROC 0.82, sensitivity = 0.39 at specificity = 0.80. Discrimination of individuals with late stage CRC from individuals with clean colorectum demonstrated AUC=ROC 0.90, sensitivity = 0.58 at specificity = 0.80. CONCLUSIONS: A subset of biomarker candidates, specifically IL8, investigated in the present study suggest a potential as blood-based biomarkers in screening of CRC.
Mental Health of People with Dementia During COVID-19 Pandemic: What Have We Learned from the First Wave?
Authors: Borg Céline ,   COVCARE Group, Rouch Isabelle , Pongan Elodie , Getenet Jean Claude , Bachelet Romain , Herrmann Mathieu , Bohec Anne-Lise , Laurent Bernard , Rey Romain , Dorey Jean-Michel
Published: June 2021

Background: People with dementia (PWD) and their caregivers are populations highly vulnerable to COVID-19 pandemic and its consequences. A better knowledge of the living conditions during the first lockdown is necessary to prevent the risk of poor mental health (PMH) in this population. Objective: The present study aimed to compare the mental health of caregivers of PWD living at home or in nursing-homes and to identify specific factors influencing their mental health. Methods: We conducted an anonymous cross-sectional online survey in France from March 17 to May 11, 2020. Three hundred and eighty-nine caregivers accompanying a PWD living at home (HC) and 159 accompanying a PWD living in a nursing home (NHC) participated in the study. Caregivers’ mental health including anxiety, depression, stress, and burden was assessed with self-reported standardized scales. Results: Half of the caregivers exhibited PMH, including depression, anxiety, or self-reported stress. Similar PMH rates were provided whatever the PWD place of residence. Regarding HC, our results also highlighted a number of risk factors for PMH, including the fact that caregiver live with PWD, to give increased support to PWD, and to feel more isolated for managing PWD since lockdown. Conclusion: PMH was observed for caregivers of PWD during lockdown, whatever PWD living place, suggesting that concern for PWD may explain more of caregiver distress than increased material tasks. In the future, it will be necessary to pay attention to caregivers after the crisis by estimating the longer-term impact on their mental health.
Aqueous extract of andean berry induces apoptosis in human colon cancer cells without mitochondrial damage
Authors: Arango-Varela Sandra S. , Torres-Camargo David , Reyes-Dieck Camilo , Zapata-Londoño Maria Bibiana , Maldonado-Celis Maria E.
Published: June 2021

BACKGROUND:

Andean berry contains several classes of phenolic compounds which have showed antioxidant and cytotoxic activity.

OBJECTIVE:

To characterize the Andean berry aqueous extract and to study their anti-proliferative mechanisms on SW480 and SW620 cell lines (human colon adenocarcinoma).

METHODS:

Total phenolic and total anthocyanins contents were determined by Folin-Ciocalteau and differential pH methods, respectively. Antioxidant activity was measured by FRAP, ORAC and DPPH methods. Antiproliferative effect was determined by sulforhodamine colorimetric method and apoptosis was analyzed by flow cytometry using propidium iodide/Annexin-V. Mitochondrial potential was evaluated using DIOC6 and ROS levels were measured by 2,7-Dicholorodihydrofluorescein diacetate (DCFH-DA).

RESULTS:

The total phenol and anthocyanin content were 4409.78± 63,05 mg equivalents of gallic acid/100 mL and 106,57± 1.43 mg equivalents of cyanidin-3-glycoside/100 mL, respectively. Andean berry extract showed antioxidant activity by FRAP, ORAC and DPPH methods and antiproliferative effect on SW480 and SW620 cells. It was observed a cell cycle arrest at S and G2/M phases on SW480 and at G0/G1 phase on SW620 cells. Aqueous extract did not induce mitochondrial depolarization or affect intracellular ROS levels.

CONCLUSIONS:

Andean berry aqueous extract has antioxidant capacity and induces apoptosis involving cell cycle arrest in SW480 and SW620 cells without mitochondrial damage.
Available supports and resources for postsecondary students with traumatic brain injury: A systematic review of the literature
Authors: Tarconish Emily , Lombardi Allison , Madaus Joseph , Taconet Ashley , Coelho Carl
Published: June 2021

BACKGROUND: Postsecondary students with traumatic brain injuries (TBI) are a rapidly growing population, encompassing those who sustained injuries prior to attending postsecondary education and those who endure injuries during their postsecondary studies. Not only do these individuals face a broad range of symptoms, all of which can affect academic achievement, but they also do not achieve comparable academic outcomes to their peers without disabilities. OBJECTIVE: There is a need to develop and examine the effectiveness of available supports and resources to meet the needs of these students. METHODS: Twenty-three articles were systematically reviewed to illustrate what supports are currently described in the literature for postsecondary students with TBI and what research methods were used to assess the effectiveness of these supports. RESULTS: Three categories of supports emerged, including concussion management protocols, typical study/learning strategies and accommodations, and interventions developed specifically for this population. Findings also indicated a lack of rigorous research methods used to assess these interventions’ effects. CONCLUSIONS: Implications for future research include a need for additional study of all supports and resources described in this review, and assessment of whether or not education professionals, including postsecondary disability services professionals, are aware of and using the tools and strategies addressed in this review.
A resource guide to understanding cerebral palsy: Commentary on collaboration to support health literacy and shared decision making
Authors: Chan Elizabeth , Frisina Cynthia , Gaebler-Spira Deborah
Published: June 2021

BACKGROUND: Shared decision-making is a newer model of patient-centered healthcare; it is particularly important for people with chronic conditions including cerebral palsy. Health literacy is the ability of an individual to obtain, communicate, process, and understand health information and is a crucial component to shared decision-making. With the abundance of information that can be found on the internet, it can be difficult to navigate and determine which websites contain reliable information. OBJECTIVE: Provide a commentary article aimed to provide healthcare professionals a current, annotated list of reliable online resources in regards to cerebral palsy throughout the lifespan with the goal of supporting health literacy and therefore improving shared decision-making and reducing disparity. CONCLUSION: Access to accurate and reliable information is an important aspect of health literacy, which in turn will optimize outcomes and build the foundation for shared decision-making between the provider and the patient. Educational materials should be easy to navigate and utilize. This article serves as a guide for reliable CP resources.
IL-18 expression in clinical human pituitary adenoma
Authors: Shao Qi , Liu Ning , Li Guo-Fu , Meng Qian-Cheng , Yao Jia-Hao , Wang Ning
Published: June 2021

BACKGROUND: IL-18 is known as an interferon-inducing factor that belongs to the IL-1 family, and is synthesized as an inactive precursor protein. OBJECTIVE: The present study aims to investigate the expression of IL-18, IL-18R, R and IL-18 binding protein (BP) mRNA in various types of human pituitary tumors, such as adrenocorticotropic hormone (ACTH), growth hormone (GH), prolactin (PRL), thyroid stimulating hormone (TSH)-producing adenomas and non-function adenomas. METHODS: Pituitary adenoma tissues were obtained during the surgery of 41 patients: nine patients had ACTH-producing pituitary adenomas, nine patients had GH-producing pituitary adenomas, five patients had TSH-producing pituitary adenomas, seven patients had PRL-producing pituitary adenomas, and 11 patients had non-functioning adenomas. The mRNA expression levels of IL-18, IL-18BP, IL-18R and IL-18R were quantified using real-time quantitative PCR. RESULTS: The mRNA expression of IL-18 was significantly higher in ACTH-, GH- and PRL-producing adenomas, when compared to non-function tumors. Similarly, a significantly higher mRNA expression of IL-18BP and IL-18R was observed in ACTH-, GH- and PRL-producing adenomas, when compared with non-functional adenomas. In contrast, no upregulation of IL-18R mRNA was observed in any of the pituitary adenomas. CONCLUSIONS: The mRNA levels of IL-18, IL-18BP and IL-18R are significantly elevated in clinical pituitary tumors, such as ACTH-, GH- and PRL-producing adenomas, when compared to non-functional adenomas. These present results suggest the possibility that IL-18 may be involved in the pathogenesis of pituitary adenoma.
Analysis of physical health with internet of things-based computational narrowband physical health framework
Authors: Zhu Yacheng , Sivaparthipan C.B. , Vinothraj V.
Published: June 2021

BACKGROUND: Physical health is vital to the improvement of our skills and the enhancement of eye movements. The coordination of good body movement helps to establish a safe position of the body. The challenging characteristics of physical education include insufficient time allocation, inadequately trained teachers, and inadequate provision of the equipment is considered as an important factor. OBJECTIVE: In this paper, IoT-based Computational Narrowband Physical Health Framework (IoT-CNPHF) has been proposed to strengthen adequate time allocation, appropriately qualified teachers, and sustainable provision in the physical education system. METHOD: Massive extended range analysis is introduced to enhance the duration and time allotted for physical activity that helps in creating awareness about the importance of physical activities and sports in our daily life. The multimodal supervised technique is incorporated with IoT-CNPHF to improve the knowledge of physical education for the teachers and to provide suitable provision for students in the physical education system. RESULTS: The simulation analysis is performed based on accuracy, performance, and its efficiency proves the reliability of the proposed framework.
Internet of things-based cloud computing platform for analyzing the physical health condition
Authors: Cui Mengyao , Baek Seung-Soo , Crespo Rubén González , Premalatha R.
Published: June 2021

BACKGROUND: Health monitoring is important for early disease diagnosis and will reduce the discomfort and treatment expenses, which is very relevant in terms of prevention. The early diagnosis and treatment of multiple conditions will improve solutions to the patient’s healthcare radically. A concept model for the real-time patient tracking system is the primary goal of the method. The Internet of things (IoT) has made health systems accessible for programs based on the value of patient health. OBJECTIVE: In this paper, the IoT-based cloud computing for patient health monitoring framework (IoT-CCPHM), has been proposed for effective monitoring of the patients. METHOD: The emerging connected sensors and IoT devices monitor and test the cardiac speed, oxygen saturation percentage, body temperature, and patient’s eye movement. The collected data are used in the cloud database to evaluate the patient’s health, and the effects of all measures are stored. The IoT-CCPHM maintains that the medical record is processed in the cloud servers. RESULTS: The experimental results show that patient health monitoring is a reliable way to improve health effectively.
Soccer player activity prediction model using an internet of things-assisted wearable system
Authors: Wu Lei , Wang Juan , Jin Long , Marimuthu K.
Published: June 2021

BACKGROUND: Soccer is one of the world’s most successful sports with several players. Quality player’s activity management is a tough job for administrators to consider in the Internet of Things (IoT) platform. Candidates need to predict the position, intensity, and path of the shot to look back on their results and determine the stronger against low shot and blocker capacities. OBJECTIVE: In this paper, the IoT-assisted wearable device for activity prediction (IoT-WAP) model has been proposed for predicting the activity of soccer players. METHOD: The accelerometer built wearable devices formulates the impacts of multiple target attempts from the prevailing foot activity model that reflect a soccer player’s characteristics. The deep learning technique is developed to predict players’ various actions for identifying multiple targets from the differentiated input data compared to conventional strategies. The Artificial Neural Network determines a football athlete’s total abilities based on football activities like transfer, kick, run, sprint, and dribbling. RESULTS: The experimental results show that the suggested system has been validated from football datasets and enhances the accuracy ratio of 97.63%, a sensitivity ratio of 96.32%, and a specificity ratio of 93.33% to predict soccer players’ various activities.
Predominant Endotype of Nasal Polyps in a Sample of Filipinos Following Endoscopic Sinus Surgery for Chronic Rhinosinusitis with Nasal Polyposis
Authors: Nable-Llanes Karla Victoria , Roldan Rodante
Published: May 2021

ABSTRACT

Objective: To determine the prevalence of eosinophilic and non-eosinophilic nasal polyps in Filipino patients with chronic rhinosinusitis with nasal polyposis (CRSwNP) who underwent endoscopic sinus surgery.

Methods:

Design: Retrospective Chart Review

Setting: Tertiary Government Training Hospital

Participants: A consecutive sample of adult patients who underwent endoscopic sinus surgery for chronic rhinosinusitis with nasal polyposis at the Rizal Medical Center from 2015-2019.

 

Results: Out of 66 patients who underwent endoscopic sinus surgery during the study period, 36 (54.55%) had an eosinophilic endotype while 30 (45.45%) had a non-eosinophilic endotype.

Conclusion: he slight predominance of eosinophilic nasal polyps found in our sample may suggest a contrasting trend compared to our Asian neighbors, who have a predominantly non[1]eosinophilic endotype – Indonesia (90.47%), Thailand (81.9%), South Korea (66.7%) and China (53.6%). However, this predominance is still lower than the 78-88% eosinophilia reported among Caucasians. Larger series may confirm these preliminary findings
Self-Inflicted Craniofacial Impalement Injury with a Screwdriver During the COVID-19 Pandemic: A Case Report
Authors: Gatela JL Jane
Published: May 2021

ABSTRACT

Objective: To present a case of a 37-year-old man presenting with craniofacial impalement injury from a screwdriver that happened during the early stages of the COVID-19 pandemic.

Methods:

Design: Case Report

Setting: Tertiary Government Training Hospital

Patient: One

Results: During the early stages of COVID-19 pandemic a 37-year-old man was brought to the emergency room with a screwdriver embedded in his right eye. A multidisciplinary team observing available recommendations (level IV PPE, carefully planned operative directives) successfully performed endoscopic endonasal transsphenoidal surgery with application of a nasoseptal Hadad flap and abdominal fat obliteration. Aside from medial gaze limitations of the right eye, there was no CSF leak or rhinorrhea and no neurologic sequelae on follow up.

 

Conclusion: Endoscopic skull base surgery for such an impalement injury as this is a formidable multidisciplinary challenge, even in normal times. The early stages of the COVID-19 pandemic presented additional challenges. Observing evolving guidelines minimized the high risk of exposure for health care workers while maximizing care for the patient.
Fenestral Otosclerosis: A Subtle Lesion Easily Missed
Authors: Yang Nathaniel
Published: May 2021

A 29-year-old Filipina of Chinese descent presented with progressive bilateral conductive hearing loss of several years’ duration. While working overseas, she consulted with an otolaryngologist and underwent computerized tomographic (CT) imaging of the temporal bone as part of her evaluation. She was informed that no abnormalities were identified in the imaging exam, and she was offered exploratory middle ear surgery with possible stapes surgery. She then sought a second opinion, with the intention of obtaining a more definitive diagnosis prior to any invasive medical intervention. A review of the CT imaging study, with particular emphasis on looking for radiologic evidence of otosclerosis, revealed the presence of a focal region of bone demineralization in the region of the fissula ante fenestram. (Figure 1) This finding is consistent with a diagnosis of fenestral otosclerosis.

 

Otosclerosis is one of the main differential diagnoses for a patient presenting with bilateral conductive hearing loss and no other visible evidence of otologic disease. Although it is more common in the Caucasian population,1 it must remain as one of the considerations in the Asiatic population, including Filipinos. High-resolution CT is the imaging technique of choice in the evaluation of conductive hearing loss.2 When evaluating a scan for evidence of otosclerosis, it must be remembered that the most common location of involvement is the bone just anterior to the oval window, in a small cleft known as the fissula ante fenestram. It is this relationship that gives rise to the term fenestral otosclerosis. The fissula is a thin fold of connective tissue extending through the endochondral layer, located in the region between the oval window and the cochleariform process, where the tensor tympani tendon turns laterally toward the malleus.3 (Figure 2) Since the average length of the stapes footplate along its short axis is around 1.5 mm, it is highly recommended that submillimeter image slice thickness be routinely ordered for the CT imaging study, in order to maximize the opportunity to identify the oftentimes small and subtle areas of focal demineralization. At a slice thickness of 0.5 mm, such a lesion might only be identified by an astute clinician in 2-3 sequential axial imaging slices.
Evolution of correlation of terms sign and symbol in general semiotics, linguistics, and cultural studies
Authors: Nadiia Pashkova
Published: June 2021

The purpose of the article is to analyze the views on the relation between sign and symbol in modern linguistics and cultural studies and to formulate a theoretical conclusion in order to avoid misunderstandings in scientific works. The methodology is based on the application of an interdisciplinary approach to the study of the central concepts of semiotics, linguistics, and cultural studies. In addition to general scientific methods of analysis and synthesis, a cultural-genetic method was used, as well as such linguistic methods as descriptive, comparative, methods of functional and conceptual-ideographic analysis. The scientific novelty of the study is that it first revealed the cause of differences in the interpretation of the relation between sign and symbol in traditional semiotics, modern linguistic and cultural studies, and formulated recommendations for their definition. Conclusions. It is proved that the opposition of sign and symbol in modern humanities is based on the special symbolism of the symbol, which distinguishes it from the other signs, classified by Ch. Pierce in traditional semiotics. Genetically, a symbol is a sign that has developed particular anthropogenic trait distinctions, contrasting with other signs, which nevertheless does not completely remove its sign properties and functions.