bluuebunny/crossref_metadata_2025 huggingface dataset:
A retrospective study on the clinico-demographic profile of multiple sclerosis patients in various tertiary care hospitals in Mangalore city of South India
Authors:   Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India, Joseph Nitin , Salins Rachel Melissa ,   Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India, Ramesh Priyanka ,   Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India, Krishna Narayana Venkatesh ,   Department of Community Medicine, Father Muller Medical College, Mangalore, India
Published: December 2021

Objectives. To study the risk factors, clinical presentations, course of the disease, investigations and management practices in MS. Materials and methods. Records of 23 patients diagnosed with MS using the McDonald diagnostic criteria were analysed. Outcomes. The mean age at diagnosis was 34.6±17.1 years. 17 (73.9%) patients were females. Early and late onset MS were present among 2 (8.7%) and 4 (17.4%) patients respectively. The most common symptom at diagnosis was paraesthesia [9 (39.1%)]. Motor symptoms and sensory symptoms at the time of diagnosis were present among 9(39.1%) patients each. 20 (87%) patients had motor system involvement, 9 (39.1%) had sensory system involvement, 12 (52.2%) had cranial nerve involvement, 4 (17.4%) had sphincter dysfunction and 2 (8.7%) had cerebellar involvement. Relapsing and remitting MS (RRMS) were present among 18 (78.3%) patients. Oligoclonal bands were present among 17 (73.9%) patients. Vitamin D levels in the blood were found deficient among 4 (80%) out of 5 patients with available reports of the same. Juxtacortical region was the most common [9 (39.1%)] site of involvement. Steroids were used for management among majority [12 (52.2%)] of the patients. Non-pharmacological methods for management constituted only physiotherapy which was advised among 13 (56.5%) patients. Improvement in treatment outcome were seen among 19 (82.6%) patients. Conclusions. Almost three fourth of the patients were females. RRMS was the most common course of the disease. Juxtacortical region was the most common site involved. Steroids were most commonly used for management. More non-pharmacological methods need to be introduced for MS management.
Bipartite graph modeling of Alzheimer’s disease and its early automated discrimination through region-based level set algorithm and support vector machine in magnetic resonance brain images
Authors:   Department of Mathematics, Kalasalingam Academy of Research and Education (KARE), Tamilnadu, India, Yegnanarayanan V. , Anisha M. ,   Department of Biomedical Engineering, Kalasalingam Academy of Research and Education (KARE), Tamilnadu, India, Prasath T. Arun ,   Department of Biomedical Engineering, Kalasalingam Academy of Research and Education (KARE), Tamilnadu, India
Published: December 2021

This paper offers a bird’s eye perception of how bipartite graph modeling could help to comprehend the progression of Alzheimer Disease (AD). We will also discuss the role of the various software tools available in the literature to identify the bipartite structure in AD affected patient brain networks and a general procedure to generate a graph from the AD brain network. Further, as AD is a minacious disorder that leads to the progressive decline of memory and physical ability we resort to Computer-Aided Diagnosis. It has a vital part in the preliminary estimation and finding of AD. We propose an approach to become aware of AD particularly in its beginning phase by analyzing the measurable variations in the hippocampus, grey matter, cerebrospinal fluid and white matter of the brain from Magnetic resonance images. Hence an appropriate segmentation and categorization methods are projected to detect the presence of AD. The trials were carried out on Magnetic resonance images to distinguish from the section of interest. The effectiveness of the CAD system was experimentally evaluated from the images considered from publicly available databases. Obtained findings recommend that the established CAD system has boundless prospective and great guarantee for the prognosis of AD.
Evaluation of frequency of depression in a subset of population with idiopathic parkinsonism in a tertiary care hospital
Authors:   Neurology, Chandka Medical College, Larkana, Pakistan, Ali Aijaz , Mahar Shafqat Hussain ,   Neurology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan, Kumar Dileep ,   Neurology, Shaheed Mohtarma Benazir Bhutto Medical College, Karachi, Pakistan, Fatima Meraj ,   Neurology, Dow University Hospital, Dow University of Health Sciences, Karachi, Pakistan, Abbas Saira ,   Neurology, Dow University Hospital, Dow University of Health Sciences, Karachi, Pakistan, Iltaf Samar ,   Neurology, Dow University Hospital, Dow University of Health Sciences, Karachi, Pakistan, Asghar Muhammad Sohaib ,   Internal Medicine, Dow University Hospital, Dow University of Health Sciences, Karachi, Pakistan
Published: December 2021

Objectives. To determine the frequency of depression in patients with idiopathic parkinsonism presenting to a tertiary care Hospital in Karachi. Material and methods. This case study was conducted at the neurology department Jinnah Postgraduate Medical Centre, Karachi (JPMC). The duration of the study was six months from 22nd January 2019 to 2nd June 2019. A total of 114 patients of parkinsonism (idiopathic Parkinson’s disease) were included in this study. Patients were assured of confidentiality. They were given questionnaire with Beck depression inventory while waiting in the neurology outpatient clinic. Questionnaire was taken back after 25 minutes. Patient score more than 9 was diagnosed as depression. The identified depressed patient was offered treatment. Results. Frequency of depression in patients with idiopathic Parkinson’s disease was observed in 48.25% (55/114) cases. Conclusions. It is concluded that our study indicates the burden of depression in Parkinson disease (PD) patients. However, even with stable or mild deficit in motor function, the wide prevalence of depression indicates that it should be suspected and treated. Over the past several years, systematic studies of depression and its treatment have contributed significantly to this most challenging psychiatric problem in PD. Hence, there is a need of policy for screening and prompt treatment of such patients so they could lead to enhance quality of life.
Efficacy of manual therapy interventions in management of lumbar prolapsed intervertebral disc: A pilot randomized controlled trial
Authors:   Department of Physiotherapy, Guru Jambheshwar University of Science and Technology, Hisar, India, Singh Varun , Malik Manoj ,   Department of Physiotherapy, Guru Jambheshwar University of Science and Technology, Hisar, India
Published: December 2021

Background. This pilot trial reports the initial estimates of the efficacy of manual therapy interventions in lumbar prolapsed intervertebral disc and determines the feasibility and acceptability of full powered “randomized controlled trial” on efficacy of “spinal mobilization with leg movement (SMWLM)”, high velocity low amplitude thrust (HVLA) and neural mobilization (NM) in lumbar PIVD (Prolapsed Inter-Vertebral Disc) and pilot data will be used to perform sample size calculation for full trial. Material and methods. 48 subjects diagnosed lumbar PIVD were randomly distributed into 4 groups. The primary outcomes were feasibility, assessment procedure, retention rate, adherence and acceptability to the intervention. The secondary outcomes measures were pain, disability and straight leg raise (SLR) range of motion. Results. 90 subjects were screened based on selection criteria. Out of them, 50 (55.55%) were eligible. 48(96%) subjects accepted to participate in study. Baseline data of all the groups was similar but post-intervention score were significant when compared the data between the groups. Highest mean change for visual analog scale (VAS), oswestry disability index (ODI) and SLR were found in SMWLM group. No adverse effects were reported by subjects. Results also suggest that the outcome measures were feasible and acceptable and the treatment considered as the beneficial approach. Conclusions. Present study suggests that it is feasible and acceptable to do a fully powered “randomized controlled trial (RCT)” to evaluate the efficacy of manual therapy interventions in management of lumbar PIVD. This study also reveals that manual therapy interventions are effective in management of lumbar PIVD.
Emerging data on the treatment of multiple sclerosis
Authors:   Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Ciuhan Andrei , Perju-Dumbravă Lăcrămioara ,   Neuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Tohănean Nicoleta ,   Neuroscience Department, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: December 2021

Background and objectives. In the past few years, a myriad of new studies were aimed to find better ways to manage MS. As a result, a bunch of new molecules were found to have good efficacy, therefore FDA and EMA approved a series of treatments in the last few years, the last one receiving green light from EMA on March 30th, 2021 (Ofatumumab – Kesimpta®). The aim of this study was to evaluate and classify three of the newest drugs approved by the FDA and EMA. Material and methods. All the studies were chosen on the basis of pre-determined inclusion criteria and in accordance with PRISMA guidelines. We searched Pubmed and Cochrane Library for all studies published up until the end of 2020. For the data analysis we used MetaInsight®, a statistical web-based tool for meta-analyses and NMAs performing both Frequentist and Bayesian hierarchical model analyses, each one being seen as a sensitivity check for the other. Outcomes. The best therapeutic agent in reported efficacy amongst the three analyzed was Ofatumumab, ranked first in hierarchy, Ozanimod and Cladribine following in the second and third place, respectively. Conclusions. According to ABN’s 2015 guidelines, Cladribine was ranked between the most effective medicines for the treatment of MS; given the results from this study, other two may be considered as high efficacy alongside Natalizumab, Alemtuzumab and Ocrelizumab.
Diagnosing a rare case of lymphocytic infiltration of the pituitary gland without the invasive procedure of pituitary biopsy
Authors:   Department of Endocrinology, First affiliated Hospital, Xian Jiaotong University, Xian, China, Khan Hamad Haider , Ullah Hameed ,   Department of Radiology, Second affiliated Hospital, Xian Jiaotong University, China, Khan Siraj Ulhaq ,   Department of Endocrinology, First affiliated Hospital, Xian Jiaotong University, Xian, China, Guo Huo ,   Department of Endocrinology, First affiliated Hospital, Xian Jiaotong University, Xian, China, Nadeem Zahid ,   Department of Cardiology, First affiliated Hospital, Xian Jiaotong University, China, Khan Faiz Ullah ,   Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xian Jiaotong University, China, Khan Farman Ullah ,   Department of Pharmacy Administration and Clinical Pharmacy, School of Pharmacy, Xian Jiaotong University, China, Hussain Shida ,   Department of Gastroenterology, Second affiliated Hospital, Xian Jiaotong University, Xian, China, Mansha Muhammad Irfan ,   Department of Endocrinology, First affiliated Hospital, Xian Jiaotong University, Xian, China, Shi Bingyin ,   Department of Endocrinology, First affiliated Hospital, Xian Jiaotong University, Xian, China
Published: December 2021

Background. Lymphocytic infiltration of the pituitary is an unusual inflammatory disorder of the pituitary and indicated to be autoimmune in origin. Presentations depend on the site of involvement and degree of destruction of the cellular population of the pituitary and may range from an asymptomatic state to pan-hypopituitarism with or without mass effects. In the present study, we represent a rare case of lymphocytic infiltration of the pituitary gland who was diagnosed with such condition and the subsequent management. Case presentation. A 22-year-old male who was admitted with symptoms of increased thirst and excessive fatigue. Following a thorough physical, clinical, laboratory, biochemistry, and imaging examinations a timely diagnosis of lymphocytic infiltration of the pituitary was made without using the invasive procedure of pituitary biopsy. In light of the diagnosis prompt management with the mainstay of glucocorticoid was started along with replenishing the other deficient hormones. In this study we describe a rare case of lymphocytic infiltration of the pituitary discussing in terms of epidemiology, sign and symptoms, laboratory evaluation, imaging studies, histopathology, management, and the usual outcome. Conclusion. Lymphocytic infiltration of the pituitary gland can be diagnosed with the clinical presentation along with lab evaluation and imaging but without pituitary biopsy, which could help in an early and accurate diagnosis which is the basis for better management of the rare condition.
Diagnosing neuro-Behçet’s disease
Authors:   Elytis Hospital Hope, Iasi, Romania, Bistriceanu Cătălina Elena , Danciu Florentina Anca ,   ”Prof. Dr. N. Oblu” Neurosurgery Clinical Emergency Hospital, Iasi, Romania, Cuciureanu Dan Iulian ,   ”Prof. Dr. N. Oblu” Neurosurgery Clinical Emergency Hospital, Iasi, Romania,   “University of Medicine and Pharmacy“ Grigore T. Popa”, Iasi, Romania
Published: December 2021

Behçet’s disease is a rare systemic vasculitis characterized by uveitis, recurrent oral and genital ulcers, firstly described by the Turkish dermatologist Hulusi Behçet. The etiology is unknown, although autoimmune mechanisms are described. There is no specific test for the diagnosis of Behçet’s disease. The International Criteria for Behçet’s Disease (ICBD) proposed a new set of diagnostic criteria including oral and genital aphthosis, skin, ocular and vascular manifestations, CNS involvement and positive pathergy test. The neurologic involvement could be classified in parenchymal neuro-Behçet’s and non-parenchymal neuro-Behçet’s disease. We report a case of a woman with a very impressive personal history. Over time, she had many specific neurological complications compatible with neuro-Behçet’s disease (NBD). The other general symptoms also suggested Behçet’s disease, according to ICBD.
Virology, pathophysiology and neuroinvasion mechanisms of SARS-CoV-2: A mini literature review
Authors:   Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran, Pourgholaminejad Arash , Kazemi Samaneh ,   Deputy of Research and Technology, Guilan University of Medical Sciences, Rasht, Iran, Saberi Alia ,   Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
Published: December 2021

Coronavirus-2 (CoV-2) is known as a respiratory pathogen for which the accumulation of evidence suggest that the severe acute respiratory syndrome (SARS) can cause critical pathologies in vulnerable patients. The coronavirus disease-2019 (COVID-19) pandemic is an example of a multi-systemic infectious disease. In addition of respiratory manifestations and severe pneumonia related to COVID-19, The SARS-CoV-2 can penetrate into the central nervous system (CNS) and participate in the induction of neurological disorders and promote some neuropathies. Knowledge of the spectrum of SARS-CoV-2-associated pathophysiology and neuroinvasion pathways will lead to improved clinical outcomes and better treatment algorithms. The aim of this review is to summarize available knowledge on the identification of virology, neuroinvasion mechanisms and the pathophysiology of SARS-CoV-2 in the CNS.
Leukocyte neutrophil ratio (NLR) as biomarker for neuroinflammation in patients with intracerebral haemorrhage and traumatic brain injury
Authors:   Department of Biochemistry, Calcutta Medical College, Kolkata, India, Ghosh Amrita , Pal Ranabir ,   Department of Community Medicine, MGM Medical College and Hospital, Bihar, India, Mishra Rakesh ,   Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India, Cincu Rafael ,   Department of Neurosurgery, General University Hospital, Valencia, Spain, Moscote-Salazar Luis Rafael ,   Department of Neurosurgery, University of Cartagena, Cartagena de Indias, Colombia, Agrawal Amit ,   Department of Neurosurgery, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India
Published: December 2021

Circulating inflammatory markers may predict the broad clinical spectrum of traumatic brain injury (TBI). The present study aimed to illustrate the role of leukocytes, precisely neutrophil and lymphocytes, in neuroinflammation as a new vista in neuro-critical care. Search terms were: elevations in peripheral blood leukocytes counts, neutrophil, lymphocyte with precisely neutrophil to lymphocyte ratios, associated with adverse outcomes of traumatic brain injury, pre and post-operative conditions of intracerebral haemorrhage, seizures, delirium, non-convulsive status epilepticus, confusion, aphasia, agitation, coma, disability and death. As a result, we identified 16 publications describing leukocyte biomarkers associated with neuroinflammation following TBI from PubMed, Cochrane Registry of Controlled Trials, Medline and Embase (Ovid) on randomised controlled trials (RCTs), non-RCTs and cohort studies published in the last decade. This study concluded that elevations in peripheral blood leukocyte and neutrophil to lymphocyte ratios could predict adverse outcomes of a cerebral haemorrhage.
Regenerative capacity of bone marrow stem cells with or without superparamagnetic iron oxide nanoparticles after facial nerve degeneration: A narrative review
Authors:   Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt, El-Latif Noura Abd , Denewar Mona ,   Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt, El-Zehary Rehab R. ,   Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt, Ibrahim Fatma M. ,   Oral Biology Department, Faculty of Dentistry, Mansoura University, Egypt
Published: December 2021

Facial palsy can be defined as a kind of paralysis affecting facial muscles. It is termed Bell’s palsy if it is unilateral. It may occur due to trauma to the facial nerve, infections as herpes zoster, neoplastic lesions, or unknown cause. It may be also associated with metabolic and systemic diseases as hypertension, toxicity, amyloidosis, alcoholism, auto-immune diseases and diabetes mellitus. Mesenchymal stem cells (MSCs) are multipotent adult stromal cells that have many benefits as an evolving treatment modality. Bone marrow stem cells (BMSCs) divide progressively in culture, and differentiate into neurons exclusively with use of a simple protocol. Most ongoing preclinical and clinical cell treatment modalities composed of local or systemic transplantation of stem or progenitor cells. In addition, they depend on the migration and retention of transplanted cells at insult areas. Nevertheless, one of the main obstacles against this modality is how to detect the fate and exact location of these cells inside the body, and how to maintain the cells at this specific site. Magnetic targeting systems, which depends on cells labelled by magnetic carriers, have been assessed as a more efficient technique for stem cell delivery to target sites. These systems depend on loading stem cells with magnetic nanoparticles and attracting them to the exact intended area within the body by placing an external magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) have been introduced in the last few years as a rising applicant of nanoparticles in a vast variety of medical fields as magnetic separation, drug delivery, magnetic resonance imaging (MRI) and magnetic hyperthermia. In addition, applications of SPIONs, as a site-specific drug carrier, diagnostic agent and stem cell delivery agent, receive most attention of researchers in that field. In this review, up-to-date information about Magnetic targeting of degenerated facial nerve by BMSCs labelled with SPIONs may suggest its capacity of better regeneration than injection of BMSCs alone.
Neuromuscular exercises: A new perspective in knee osteoarthritis
Authors:   Department of Physiotherapy, Guru Jambheshwar University of Science &Technology, Hisar, Haryana, India, Sabharwal Jyoti , Joshi Shabnam ,   Department of Physiotherapy, Guru Jambheshwar University of Science &Technology, Hisar, Haryana, India
Published: December 2021

Background. Knee osteoarthritis (OA) is the most prevalent arthropathy across the world. It presents with swelling, pain, decreased range of motion (ROM) and instability. Patients also complain of thigh muscle weakness and lower limb weakness resulting in poor joint shielding and joint overload. Owing to these presenting features patients are prone to increased risk of morbidity and are forced to live with functional impairment. Exercises are one of the vital intervention programme used in knee OA. Exercises lead to improvement in physical function, strengthening of the muscles and reduction in pain. Neuromuscular exercises have effects on functional performance, biomechanics and activation pattern of surrounding musculatures of the patient. Therefore, neuromuscular exercises may prove to be beneficial in enhancing the efficacy of exercise training programmes in such patients due to functional instability and disturbed neuromuscular function. Purpose. This article intends to review the effect and role of neuromuscular exercises in the management of knee osteoarthritis. Method. Comprehensive computerized search was performed on Google Scholar, Pubmed and Cochrane. Conclusion. By evaluating various articles on neuromuscular exercises in knee osteoarthritis the present review suggest that neuromuscular exercises are helpful in the treatment of knee osteoarthritis.
Impact of delivery mode on oral health
Authors:   Department of Oral Pathology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Părlătescu Ioanina , Epistatu Dragoș ,   Department of Radiology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Pîrvu Raluca Ema ,   Department of Oral Pathology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Bohîlțea Roxana Elena ,   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania, Perlea Paula ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Varlas Valentin ,   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, Filantropia Clinical Hospital, Bucharest, Romania
Published: December 2021

The route of delivery influences the gut microbiota and the development of the immune system. At the moment of birth, cesarean section infants have a lower diversity of bacteria when compared to naturally born infants. The delivery mode does influence the oral cavity colonization of infants, but there is no relevant association with dental caries.
The functions of lactoferine in the oral cavity
Authors:   Disciplina de Odontologie, Endodonție și Patologie Orală, Universitatea de Medicină și Farmacie„Iuliu Hațieganu“, Cluj-Napoca, România, Iozon-Ene Sofia , Soancă Andrada ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România, Roman Alexandra ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România, Páll Emoke ,   Disciplina de Boli Infecțioase, Universitatea de Științe Agricole și Medicină Veterinară, Cluj-Napoca, România, Ciurea Andreea ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România, Oneț Diana ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România, Stanomir Alina ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România, Popescu Dora Maria ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie, Craiova, România, Micu Iulia Cristina ,   Disciplina de Parodontologie, Universitatea de Medicină și Farmacie „Iuliu Hațieganu“, Cluj-Napoca, România
Published: December 2021

Lactoferrin is a cationic glycoprotein found in different compartments of the body and secreted mostly by glandular epithelia and neutrophils. Although initially considered that its functions derive solely from its iron-binding capacity, further research demonstrated the pleiotropic nature of the glycoprotein. Thereby, lactoferrin fulfills various essential physiological functions based on its anti-infectious, immunomodulatory and antioxidative properties. In the oral cavity, lactoferrin is an central component of the local defense mechanisms, and based on its versatility, it can prevent the occurrence and progression of different local pathologies, including periodontitis. Microbiological and inflammatory periodontitis-induced modifications influence the local levels of secreted lactoferrin, the protein becoming a potential diagnosis biomarker of periodontal disease. Moreover, lactoferrin has a potential adjunctive therapeutic benefit in periodontal treatment, based on the interference of the biomolecule with local microorganisms, its anti-inflammatory and antioxidative activity. Additionally, the adverse effects of lactoferrin administration seem less evident as compared to other adjunctive agents. Thus, the present study aims to review the most important characteristics of lactoferrin in different oral pathologies, particularly in periodontitis.
Peculiarities of calcium-phosphorus homeostasis of the oral fluid in young patients with primary hypothyroidism, having generalized periodontitis
Authors:   Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine, Mykolaivna Repetska Oksana
Published: December 2021

The problem of hormonal imbalance in periodontal diseases, as well as the importance of endocrine diseases in its development, plays a significant role. In the professional literature there are data that thyroid disease is a risk factor for the occurrence and further progression of periodontal diseases. The processes of bone modeling and remodeling and its mineralization are closely related to calcium metabolism. The biochemical manifestation of osteoporotic processes in the alveolar bone in generalized periodontitis is a violation of calcium-phosphorus homeostasis against the background of altered markers of bone metabolism. The aim of our investigation was to study the calcium-phosphorus homeostasis of the oral fluid in patients with primary hypothyroidism and persons without endocrine pathology, with generalized periodontitis. Since in the structure of periodontal diseases in the study groups generalized periodontitis of the initial-I and II degree had the largest percentage, biochemical studies were performed in this sample of patients. The first group included 50 people with generalized periodontitis against the background of primary hypothyroidism: 25 patients – with generalized periodontitis of the initial-I degree and 25 patients with generalized periodontitis of the II degree of development. The second group included 50 patients with generalized periodontitis without endocrinological pathology (25 patients with GP of the initial-I degree and 25 patients with GP of the II degree of development). In young people with generalized periodontitis, against the background of hypothyroidism, there were observed negative changes in calcium-phosphorus homeostasis of the oral fluid: there was a tendency to the decrease of calcium content in the oral fluid with the development of inflammatory-dystrophic process in the periodontium, on the contrary, phosphorus level has increased. Negative dynamics of calcium-phosphorus molar coefficient was found in patients with hypofunction of the thyroid gland. Thus, the analysis of research results shows that in young people with periodontal diseases and hypothyroidism there is a pathological change in metabolic processes, increased excretion of mineral components, especially calcium. Periodontal pathology against the background of hypothyroidism is characterized by the development of a chronic inflammatory process together with a pronounced decrease in calcium-phosphorus homeostasis of the oral fluid.
Perception of the importance of oral hygiene in a group of adults from South-West Romania
Authors:   Department of Periodontology, Craiova University of Medicine and Pharmacy, Craiova, Romania, Popescu Dora Maria , Soanca Andrada ,   Department of Periodontology, “Iuliu Hatieganu“ University of Medicine and Pharmacy, Cluj-Napoca, Romania, Pitru Allma ,   Department of Oral Pathology, Craiova University of Medicine and Pharmacy, Craiova, Romania, Salan Alex ,   Department of Oral Surgery, Craiova University of Medicine and Pharmacy, Craiova, Romania, Gheorghe Dorin Nicolae ,   Department of Periodontology, Craiova University of Medicine and Pharmacy, Craiova, Romania, Surlin Petra ,   Department of Periodontology, Craiova University of Medicine and Pharmacy, Craiova, Romania
Published: December 2021

Oral hygiene is a dental procedure with the role of removing bacterial plaque and action to prevent oral diseases, including periodontal disease. Oral prophylaxis includes both daily dental hygiene (daily brushing, flossing and mouthwash) and the visits to the dentist for professional hygiene and prophylaxis. The correct brushing of the teeth is important not only for maintaining oral health but also for the health of the whole body, because there are correlations between diseases of the oral cavity and problems of the digestive tract or even heart disease.
Comparative occlusal study analog and digital – a pilot study
Authors:   Department of Prosthodontics, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Buduru Smaranda ,   Stomestet Clinic, Cluj-Napoca, Romania, Taut Manuela ,   Stomestet Clinic, Cluj-Napoca, Romania, Bacali Cecilia ,   Department of Prosthodontics, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Manziuc Manuela ,   Department of Prosthodontics, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Serban Tudor ,   Faculty of Dentistry, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania, Culcitchi Cristian ,   Stomestet Clinic, Cluj-Napoca, Romania, Mitariu Mihai ,   “Lucian Blaga“ University of Medicine and Pharmacy, Sibiu, Romania, Negucioiu Marius ,   Department of Prosthodontics, “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania
Published: December 2021

The aim of this study was to determine whether or not the analysis of maximal intercuspation, protrusive and laterotrusive movements requires an additional digital method of occlusal diagnosis using the T-Scan™ Novus™ device (TekScan). In this observational study, we retrospectively examined a number of 10 subjects which were divided into 2 groups: the 1st group involved patients with intact dental arches and the 2nd group with patients that had received implant-supported restorations. The methods of analysis involved the calibrated articulating paper of 200 and 40 micrometers, and also the T-Scan™ Novus™ device (TekScan). The following data were collected: contact points in maximum intercuspation (functional and premature contacts), the pairs of teeth performing protrusion and right/left laterotrusion, active/passive interferences and premature contacts during protrusion and right/left laterotrusion. Descriptive statistics were obtained using the MedCalc Statistical Software version 19.2.6 (MedCalc Soft-ware bv, Ostend, Belgium) and Microsoft Excel for MAC 2011. It was tested if a statistically significant difference existed between the diagnostic methods regarding the number of contact points. The T test for independent samples without the assumption of equal variances and the Mann-Whitney test was used (to which we reported the medians of the 2 subgroups and the P value adjusted for equalities) and also the magnitude of association using the Chi-square test (p value) was measured. Also it was studied the correlation between the number of premature contacts and the number of contact points, respectively, obtained by each diagnostic method, and we expressed the results through the Spearman correlation coefficient. The analysis of the maximum intercuspation, of the protrusive and the laterotrusive movements has shown comparable results using the two examination methods. There were no statistically significant differences between the two methods of analyzing dental occlusion.
A radiological study method of vertical alveolar resorptions using immediate dental implants
Authors:   Department of Dental Radiology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Epistatu Dragos , Ciolacu Andreea ,   Department of Dental Radiology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Kitsou Aikaterina ,   Department of Dental Radiology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Părlătescu Ioanina ,   Department of Oral Pathology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Dincă Octavian ,   Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Vlădan Cristian ,   Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Dogioiu Florin ,   Department of Dental Radiology, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania, Varlas Valentin ,   Department of Obstetrics and Gynecology, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics and Gynecology, “Filanthropia“ Clinical Hospital, Bucharest, Romania, Perlea Paula ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila“ University of Medicine and Pharmacy, Bucharest, Romania
Published: December 2021

Dental extraction is followed by decreases in alveolar volume, vertically and horizontally. This retrospective study measured vertical alveolar resorption after insertion of immediate implants, using OPG, without CBCT or additional radiographs. Patients were randomly split in two groups A (57 implants) and B (47 implants). Measurements were made by two independent observers. The types of implants were: Exacta (Biaggini Medical Devices), Nova, Dentix Millenium and Surcam. The method was based on the size of the implant and another common element of the two radiographs. It used an optimal radiologic exposure. It can be generalized to other studies. Similar results measured in the two groups showed that alveolar remodeling does not depend on the type of the implant. Half of the alveoli did not have any resorption. Another quarter showed barely perceptible clinical resorption (1-2 mm). In the last quarter were registered all the notable resorptions that were associated with various factors (temporary mobile prosthesis, surgical flap, medication and some health problems, smoking, etc.) showing real situations, not ideal conditions. Maximum resorption was unique (7.63 mm).
Case selection in dental bleaching
Authors:   Department of Restorative Odontotherapy, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Gheorghiu Irina-Maria , Perlea Paula ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Scarlatescu Sanziana ,   Department of Endodontics, Faculty of Dental Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Nicola George ,   Department of Medical Legal Elements and Malpractice, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania
Published: December 2021

Dental bleaching is a method of treatment for tooth discoloration that uses hydrogen peroxide in various concentrations. For this dental maneuver to be successful, the etiological diagnosis of dental dyschromia and the treatment plan must be rigorously established. In this article we present the criteria underlying the selection of patients who can benefit from dental bleaching, grouped in a questionnaire. Adequate case selection suitable for teeth whitening, as well as the appropriate choice of the specific bleaching method are essential in obtaining satisfactory aesthetic result for the patient, immediately after completing the treatment, but also in the long term.
ANALISIS PENATAUSAHAAN ASET TETAP BARANG MILIK NEGARA (BMN)
Authors: Ramdany Ramdany , Setiawati Yuni
Published: December 2021

Penelitian ini bertujuan untuk mengetahui kesesuaian pelaksanaan penatausahaan Barang Milik Negara (BMN) pada satuan kerja Sekretariat Jenderal Kementerian Perdagangan dengan Peraturan Menteri Keuangan nomor 181/PMK.06/2016 tentang Penatausahaan BMN dan efektifitas aplikasi Sistem Informasi Manajemen Akuntansi Barang Milik Negara (SIMAK BMN). Pendekatan penelitian ini adalah kualitatif deskriptif dengan metode pengumpulan data berupa wawancara, observasi, dan studi pustaka. Hasil penelitian menunjukkan bahwa secara keseluruhan pelaksanaan penatausahaan BMN berupa aset tetap dan efektivitas SIMAK BMN pada satuan kerja Sekretariat Jenderal Kementerian Perdagangan cukup optimal namun perlu ada perbaikan seperti masih ditemukan asset yang belum tercatat dalam Daftar Barang di Ruangan (DBR) dan Daftar Barang di Luar Ruangan (DBL), permasalahan pemutakhiran data asset, penyimpanan dokumen BMN, tindak lanjut inventarisasi asset yang tidak ditemukan, dan masalah sumber daya manusia. Diharapkan kebijakan mengenai penataan BMN selanjutnya memperbaiki temuan penelitian diatas sehingga dapat meningkatkan kualitas informasi laporan keuangan dan akuntabilitas penyelenggaraan entitas public
KESUKSESAN SISTEM INFORMASI AKUNTANSI: DUKUNGAN MANAJEMEN PUNCAK DAN KEMAMPUAN SUMBER DAYA MANUSIA
Authors: Aulia Sakura , Fitrios Ruhul , Putra Adhitya Agri
Published: December 2021

Penelitian ini bertujuan untuk menguji pengaruh dukungan manajemen puncak dan kemampuan sumber daya manusia terhadap kesuksesan sistem informasi akuntansi pada organisasi perangkat daerah di kabupaten/kota di pesisir utara. Metode penelitian yang digunakan adalah metode analisis deskriptif dan kausalitas. Dalam penelitian ini populasi tersampel sebanyak 104 organisasi perangkat daerah. Analisis data yang digunakan dalam penelitian ini adalah Smart PLS, sedangkan data yang digunakan adalah kuesioner yang telah diisi oleh masing-masing Organisasi Perangkat Daerah (OPD). Hasil penelitian menyimpulkan bahwa dukungan manajemen puncak berpengaruh signifikan terhadap keberhasilan sistem informasi akuntansi dan kemampuan sumber daya manusia berpengaruh signifikan terhadap keberhasilan sistem informasi akuntansi. Implikasi pada penelitian ini adalah bahwa pengguna sistem informasi yang berkompeten akan menghasilkan sistem dan informasi yang berkualitas.
EVALUATING LOGISTICS VILLAGES IN TURKEY USING HYBRID IMPROVED FUZZY SWARA (IMF SWARA) AND FUZZY MABAC TECHNIQUES
Authors: Hashemkhani Zolfani Sarfaraz , Görçün Ömer Faruk , Küçükönder Hande
Published: December 2021

Positioning in the right location for organizing logistics activities is a determinative factor in the aspect of costs, effectivity, productivity, and performance of these operations carried out by logistics firms. The proper logistics village selection is a crucial, complicated, and time-consuming process for decision-makers who have to make the right and optimal decision on this issue. Decision-makers need a methodological frame with a practical algorithm that can be implemented quickly to solve these decision-making problems. Within this scope, the current paper aims to present an evaluation tool, which provides more reasonable and reliable results for decision-makers to solve the logistics village selection problem that is very complicated and has uncertain conditions based on fuzzy approaches. In this study, we propose the Improved Fuzzy Step-Wise Weight Assessment Ratio Analysis (IMF SWARA), a modified and extended version of the traditional fuzzy Step-Wise Weight Assessment Ratio Analysis (F-SWARA) to identify the criteria weights. Also, we suggest applying the fuzzy Multi-Attributive Border Approximation area Comparison (F-MABAC) technique to determine the preference ratings of the alternatives. This combination has many valuable contributions. For example, it proposes to use a more reliable and consistent evaluation scale based on fuzzy sets. Hence, decision-makers can perform more reliable and reasonable pairwise comparisons by considering this evaluation scale. Besides, it presents a multi-attribute evaluation system based on the identified criteria weights. From this perspective, the proposed model is implemented to evaluate eight different logistics village alternatives with respect to nine selection criteria. According to the analysis results, while A8 is the most appropriate option, C1 Gross National Product (GNP) is the most significant criterion. A comprehensive sensitivity analysis was performed to test the robustness and validation of the proposed model, and the results of the analysis approve the validity and applicability of the proposed model. As a result, the suggested integrated MCDM framework can be applied as a valuable and practical decision-making tool to develop new strategies and improve the logistics operations by decision-makers.
Remuneration of Professional Soldiers in the Czech Republic and in the Slovak Republic
Authors: Davidová Monika , Holcner Vladan , Jílek Libor , Flachbart Alojz
Published: December 2021

The paper analyses differences in remuneration of professional soldiers in the Czech Republic and the Slovak Republic between 1999 and 2020. This structural analysis focuses on changes in respective remuneration systems and their design. Results of the presented research enable to identify differences in the development of remuneration of professional soldiers after the split of the Czechoslovak Federation in 1993. The paper submits development of the amounts of salary for selected military ranks, their comparison and relation to general trends in domestic labor market and relation to average costs of living in respective countries. Between 2016 and 2019, salaries of professional soldiers grew higher in the Czech Republic than in the Slovak Republic, in 2020, the pay gap is already narrowing.
The Effectiveness of Autologous Serum and Single-dose Oral Doxycycline in the Treatment of Acne Vulgaris: A Pilot Clinical Trial
Authors: Massi Muhammad Nasrum , Yunus Muhlis , Anwar Anis Irawan , Djawad Khairuddin , Wahab Siswanto , Minhajat Rahmawati , Bahrun Uleng , Patellongi Ilhamjaya , Alam Gemini , Budayanti Ni Nyoman Sri
Published: December 2021

Introduction: Acne vulgaris is a chronic inflammatory disease that occurs with various factors, both intrinsic and extrinsic. Treatment of choice can vary from topical, systemic or a combination of both depending on the degree of severity. Recently, treatment using products from human blood has been widely studied, including in the field of dermatology as it has a unique composition.
Objective: to assess the effectiveness of autologous serum and single-dose oral doxycycline in the treatment of acne vulgaris
Methods: this clinical trial compared two groups which received autologous serum only and autologous serum combined with single dose of oral 200 mg doxycycline, respectively. Photographic pictures and number of lesions (blackheads, papules, pustules) were compared before and after application using Wilcoxon test.
Results: A total of 20 participants participated in this study. Both treatment groups showed significant decrease in lesion count (p <0.01). However, the group which received autologous serum and single dose of oral doxycycline showed superior improvement of inflammatory acne lesions.
Conclusion: autologous serum and single dose of oral doxycycline was superior to autologous serum only in the treatment acne lesions.
Keywords: Acne Vulgaris, Doxycycline, Autologous Serum
Willingness to Vaccinate against Coronavirus Disease 2019 and Related Predictors among Non-Healthcare Personnel in Indonesia
Authors: Baroroh Faridah , Suzalin Ferawati , Indriani Indriani , Sangadah Siti , Istiningrum Istiningrum , Wahyudi Guntur Ilham , Rafdilla Muhammad Rayhan Nadhil
Published: December 2021

BACKGROUND: Herd immunity against COVID-19 can be realized when a minimum of 62% of the vulnerable population has been vaccinated. However, achieving uptake of recommended vaccination in the targeted population ultimately lies with the community's willingness. Vaccine skepticism varies across demographic characteristics and stems from the perceived threats of being infected with COVID-19 while receiving the vaccine.

AIM: This research was intended to determine the willingness to vaccinate against COVID-19 and its associated factors.

METHODS: It employed a cross-sectional, then the collected data were analyzed using descriptive analytics: difference test and relationship analysis. Study with two online surveys on Google Forms and non-healthcare personnel as the research subjects. Screening with inclusion and exclusion criteria yielded 862 respondents spread over 32 provinces in Indonesia

Results: showed no difference in COVID-19 knowledge scores in surveys 1 and 2 (76.0‒77.2; p=0.08). Age and education level are significantly related to COVID-19 knowledge scores (p<0.05). About 42.4% of respondents in survey 1 and 55.6% in survey 2 were willing to receive the vaccine, with 36.8‒45.3% feeling hesitant. The main reason for vaccine hesitancy (42.2%) and unwillingness (43.2%) was mistrust in the effects or benefits of the vaccine. Although demographic characteristics are not related to the willingness (p>0.05), the opposite is true for the COVID-19 knowledge level [OR:1.66; 95% CI:1.26–2.18].

Conclusion
about half of the non-healthcare personnel (42.4‒55.6%) are willing to receive the vaccine, with knowledge of the disease being a predictor (p=0.00).
Health Behavior of Adolescent Smokers During Covid-19 Pandemic
Authors: Helina Muria , Jayaputra Novi Hendrika , Palutturi Sukri
Published: December 2021

AIM: This research aims to determine the health behavior of adolescent smokers during the COVID-19 pandemic.

METHOD: Both quantitative and qualitative analyses were conducted simultaneously using the design of “t” and Chi-square test through the distribution of questionnaires to 135 respondents as well as descriptive design and case studies, respectively. The data were collected by 13 informants through in-depth interviews, observation, and documentation.

RESULTS: The results showed that 5 out of the 6 indicators of the demographic characteristics were correlated to the economic pressure of the families of adolescent smokers which also correlates with their health behavior during the COVID-19 pandemic.

CONCLUSION: The increase in the price of cigarettes and family control are measures that regulate children from buying cigarettes.