bluuebunny/crossref_metadata_2025 huggingface dataset:
Plantas medicinais com potencial uso na fitoterapia antidepressiva: uma revisão
Authors: Viana Daniel Saboia , Nascimento Pablo Rafael Serêjo do , Miranda Junior Raimundo Nonato Cardoso
Published: November 2021

As plantas medicinais têm sido amplamente empregadas em formulações para diversas indicações terapêuticas. Algumas espécies têm sido estudadas para o tratamento de transtornos psíquicos como a depressão, dentre elas estão Rhodiola rosea L., Crocus sativus L. e Hypericum perforoatum L. A procura de terapias à base de plantas medicinais tem aumentado, o que denota o crescente aumento da relevância desta área. Este artigo possui objetivo de identificar a atividade das espécies em destaque como alternativas naturais no tratamento da depressão através de uma revisão de literatura envolvendo artigos entre 2010 e 2020 retirados da plataforma Pubmed, Scielo e Lilacs. Das espécies em estudo utilizadas para o tratamento alternativo da depressão, três estão em maior evidencia, destas sendo: o Hypericum perforatum L., também conhecida como Erva de São João; Rhodiola rosea L., para estados de depressão em adultos, há alguns estudos em animais e humanos que sugerem uma putativa ação antidepressiva; e o Crocus sativus L., sendo uma das especiarias mais caras do mundo, devido ao seu cultivo e forma como é colhido. Conclui-se que as espécies estudadas possuem extensa possibilidade de inserção no tratamento da depressão, seja em adolescente, adultos, idosos e até mesmo mulheres amamentando ou em depressão pós-menopausa. Assim, espera-se que tais resultados contribuam com o direcionamento de novos estudos sobre as espécies em questão, orientando pesquisas em outras áreas que possam ainda não terem sido exploradas bem como outros compostos extraídos que possam se mostrar promissores para a comunidade científica como alternativa terapêutica.
Sexualidade das pessoas com deficiência e Direitos Humanos: preconceito, discriminação e barreiras a vivências do desejo
Authors: Maranhão Gabriel Carlos da Silva Carneiro
Published: November 2021

O presente artigo tem o intuito de problematizar como a sexualidade das pessoas com deficiência permanece um tabu no seio social, a partir de discursos que invisibilizam e discriminam o desejo sexual desses indivíduos. Busca-se analisar como o afeto entre essas pessoas é percebido como “pervertido”, pois foge do parâmetro de normalização da sexualidade, além de perceber como o preconceito em torno das relações afetivas dos indivíduos com deficiência reforça o discurso de marginalização e exclusão histórica desse grupo social, intensificando os estigmas voltados àqueles que não se enquadram no padrão de indivíduo “saudável” ou “sem problemas”. Pretende-se, na contramão do discurso discriminatório, contribuir para romper com os estereótipos que rondam a sexualidade da pessoa com deficiência, a partir da construção do direito à subjetividade e à vivência do desejo sexual, assim como qualquer outro indivíduo. A metodologia utilizada consiste em uma análise do objeto a partir de revisão bibliografia sobre o tema nas áreas de gênero e sexualidade, direitos humanos, e direitos das pessoas com deficiência. Utilizamos como método de procedimento o estudo de caso para analisar comentários injuriosos da blogueira Julia Salgueiro contra um bebê com síndrome de Down no Facebook e os desdobramentos na mídia. Como resultado, constatou-se que, pelo senso comum, as pessoas com deficiência ainda são vistas como “assexuais”, sem desejo ou estranhos e são alvo de interdições diretas ou indiretas ao seu direito à sexualidade pela sociedade. Sendo assim é preciso avançar no debate, dando voz a esses sujeitos e suas vivências.
Assistência farmacêutica no cuidado à saúde na atenção primária: uma revisão integrativa da literatura
Authors: Araújo Maria Fabiana Ferreira de , Souza Rodrigues Ferreira de , Figueiredo Erick Frota Gomes
Published: November 2021

O objetivo do presente estudo foi analisar a importância da assistência farmacêutica no cuidado à saúde dentro da atenção primária, fazendo-se entender o papel primordial do farmacêutico no cuidado centrado no indivíduo e no coletivo. Trata-se de um estudo do tipo revisão integrativa da literatura, descritiva, onde foi pesquisado publicações de cunho científico indexadas nas bases de dados online Biblioteca Virtual em Saúde – BVS (Medline, IBECS e LILACS) e SCIELO dos anos de 2016 a 2021. Foram recuperados 167 artigos, sendo 80 resultados da base de dados MEDLINE, 46 na LILACS, 14 na IBECS, 27 na SCIELO. Após leitura dos títulos e resumos foram selecionados 20 artigos. Observou que a concretização da assistência farmacêutica (AF) é vista como uma das ferramentas para o fortalecimento dentro do Sistema Único de Saúde (SUS). Isso está diretamente ligado ao desenvolvimento da sua gestão participativa no sistema, designo este que garante o acesso aos medicamentos e à integralidade da assistência terapêutica. A inclusão do farmacêutico nesse contexto impacta positivamente na saúde da população quando o mesmo trabalha ao lado da população, cuidado e promovendo saúde, realizando estratégias voltadas para bem-estar do indivíduo e da família.
Assistência farmacêutica nas consequências do uso de anfetaminas por motoristas de caminhão: revisão integrativa
Authors: Cabral Marcos Riverson Azevedo , Silva Reginaldo Costa da , Marquez Carolinne de Oliveira
Published: November 2021

O uso de anfetaminas é considerado um problema de saúde pública, pois estão entre as drogas mais utilizadas mundialmente. O seu consumo é comum entre caminhoneiros para reduzir seu tempo nas estradas chegando rapidamente ao seu destino. Nas drogarias as consequências relatadas para os farmacêuticos após o efeito de seu uso são distúrbios do sono, irritabilidade, agitação nervosa, lapsos de memória e hipertensão e nesse momento deverá ocorrer a assistência farmacêutica para orientar sobre os perigos de seu uso. Mostrar como a assistência farmacêutica pode auxiliar nos cuidados as consequências do uso de anfetaminas por motoristas de caminhão. Os materiais utilizados foram artigos publicados entre os anos de 2016 a 2021, pesquisados nas plataformas de pesquisa: SciELO (Scientific Eletronic Library Online) e Google Acadêmico. Os métodos utilizados são: revisão sistemática da literatura, com aplicação do método qualitativo de pesquisa. Estudos mostram que os caminhoneiros ao consumir anfetaminas levam o SNC – Sistema Nervoso Central a captar ações e através de mediadores respondem com estímulos de destreza, autoconfiança e inibindo o sono e os motoristas se arriscam nas rodovias por prolongarem sua jornada sem descanso e como consequências podem provocar efeitos rebote causando acidentes evolvendo outras pessoas devido a oscilação de respostas no SNC. O uso de anfetaminas por caminhoneiros é uma das principais caudas de acidentes nas estradas e rodovias incluindo vítimas fatais geradas por seus efeitos e os farmacêuticos durante a assistência devem orientar que o uso dessas substâncias pode trazer riscos consideráveis a saúde, incluído as doenças crônicas.
As causas locais de superlotação em um serviço hospitalar de emergência de Sergipe
Authors: Alcântara Romário Torres , Campos André Luiz Baião , Ramos Jessika Valeska Martins
Published: November 2021

A superlotação é um problema presente mundialmente que assola os mais diversos países e serviços públicos de saúde, assim, a identificação de suas causas é um desafio para gestores e líderes governamentais. Diante disto, este estudo objetivou descrever as principais causas locais de superlotação em um serviço de emergência do estado de Sergipe. Alguns dos passos galgados para chegar lá foram conceituar superlotação em serviços hospitalares de emergência e apresentar as principais causas de superlotação, descrever as características do serviço estudado bem como apontar seus dados estatísticos de superlotação, comparar estes dados com as causas apresentadas e diante disso a possível causa para a superlotação. Para tanto, foi utilizado como método para coleta de dados a pesquisa documental, através do estudo de dados estatísticos frente a referenciais teóricos acerca da Superlotação de Serviços Hospitalares de Emergência e suas causas e dados publicados pelo DATASUS. A partir da análise dos dados foi possível identificar alguns fatores causais desencadeadores da superlotação no serviço estudado. Observou-se um grande influxo de pacientes ao serviço, bem como uma média de permanência elevada devido à escassez de recursos para atender a demanda do serviço. Enfim, por meio de todo o estudo realizado e dos dados apresentados foi possível se identificar que a superlotação no serviço estudado possui causas multifatoriais e há a necessidade de uma maior investigação. Desta forma, faz-se necessário o incentivo a mais pesquisas e ao aprimoramento da disponibilidade de dados para análise.
Fatores de risco da automedicação em gestantes: um estudo sobre os Anti-inflamatórios não esteroides
Authors: Silva Nelma Menezes da , Rodrigues Junior Omero Martins
Published: November 2021

Objetivo: Analisar os riscos potenciais às Gestantes e Fetos, causados pela automedicação de anti-inflamatórios não esteroides. Métodos: A proposta de metodologia para esta pesquisa segue uma estratégia de revisão de literatura, pesquisa exploratória e descritiva, cuja coleta fora realizada em diferentes bases de dados, tais como Scientific Electronic Library Online (SCIELO), registros tanto da Biblioteca Virtual em Saúde (BVS), quanto registros da Medical Literature Analysis and Retrievel System Online (MEDLINE/PUBMED). A busca se deu através do uso dos descritores “AUTOMEDICAÇÃO”; “GESTANTES”, “AINES” e “RISCOS”. Resultados: Percebeu-se que a utilização de medicamentos durante a gravidez pela prática da automedicação com Ibuprofeno 9 (27%), Dipirona 6 (18%), Bromoprida 2 (6%), Paracetamol 13 (40%), Dimenidrinato 3 (9%), sendo 31 (94%) em forma de comprimidos foi relatada por 27 (33,75%) gestantes, e 3 (11,1%) que apresentaram queixas de uso como cefaleia, êmese e náuseas e a indicação foi relatada por 2 (6%) gestantes pela a mãe e as demais por conta própria. Conclusão: Após a análise de diversos artigos científicos, o que fica bem explicito é que, o uso de anti-inflamatórios não esteroidais no início da gravidez não demonstrou ser um fator de risco, porém, após o primeiro trimestre pode ser fatal, tanto para a ocorrência de malformações congênitas estruturais no feto, quanto para problemas renais. Em se tratando da Mãe percebe-se que os AINEs podem prolongar seu tempo de parto, causar hemorragias e enfraquecer seus óvulos para uma futura reprodução.
Controle de qualidade de vinagres comercializados em Manaus
Authors: Souza Nistefanny Santana de , Pereira Layla Talissa Tundis , Souza Gabriel Oliveira de
Published: November 2021

O vinagre caracteriza-se como uma solução diluída a base de ácido acético, estabelecida por dois processos: a fermentação alcoólica, quando o açúcar é modificado para etanol; e a oxidação fermentativa, convertendo o álcool em ácido acético. Com isso, ao longo da história, ele vem sendo usado como condimento e conservante de alimentos, além de ser constituído por propriedades nutritivas e biorregulatórias apontadas como complementos fundamentais na alimentação. O vinagre pode manifestar efeitos positivos fisiológicos relacionado com a regulação pressão arterial, controle da glicose sanguínea,  auxílio na digestão e estimulação do apetite. O objetivo do estudo foi avaliar a qualidade de amostras de vinagres comercializados em Manaus.  Foram selecionadas aleatoriamente 5 amostras de vinagres de diferentes marcas identificadas como amostras A, B, C, D, E, encontradas em estabelecimentos comerciais da cidade de Manaus-AM, no período de setembro a outubro de 2021. O teor de ácido acético nos vinagres foi quantificado seguindo metodologia adaptada de Baccan, 2001. O teor do ácido acético quantificado nos vinagres variou de 3,08% a 4,57%.  As amostras C, D e E apresentaram valores de acidez abaixo do padrão estabelecido, os demais apresentaram valores de acidez de acordo com o que preconiza a legislaçãoa legislação vigente.
Processo de letramento nos Anos Iniciais de ensino: uma pesquisa bibliográfica a respeito da temática e seus aspectos históricos e metodológicos
Authors: Nunes Bruna Alves , Silva Denilson Fernandes da , Santos Poliana Bonfim
Published: November 2021

O presente artigo tem como objetivo geral analisar a importância do letramento nos anos iniciais de ensino por meio de uma revisão de literatura, o qual utilizou-se critérios de inclusão e exclusão nas bases de dados de pesquisas, servindo assim como viés principal para analisar a documentação abordando a temática de maneira recente e o seu impacto na formação da criança enquanto sujeito alfabetizado e letrado. Cujo letramento é o ensino, desenvolvimento e uso competente da leitura e escrita no ambiente social, enquanto alfabetizado simplifica-se a definição para o sujeito que sabe ler e escrever mediante a utilização de um código. Assim concluiu-se mediante a análise da literatura que a ação de ensinar letrando causa por sua vez dificuldades para o professor alfabetizador sobretudo na tentativa de conciliar a prática pedagógica com a teoria.
Organization of work of the Khabarovsk branch of the The S. Fyodorov Eye Microsurgery Fedaral State Institution the Ministry of Health of Russia in the context of the spread of a new coronavirus infection
Authors:   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, Kolenko O.V. , Yegorov V. V. ,   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, Pshenichnov M.V. ,   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, Baleva O.B. ,   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, Savchenko N.V. ,   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, Pryadko O.A. ,   The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch
Published: November 2021

The article provides information and analyzes the regulatory documents adopted in the Russian Federation, the Khabarovsk Krai, and the orders of the director of the Khabarovsk branch of the. 1The S. Fyodorov Eye Microsurgery Fedaral State Institution, the Khabarovsk Branch, of the Ministry of Health of Russia on ensuring epidemiological well-being by organizing assistance to patients with diseases of the organ of vision and adnexa in the context of the spread of a new coronavirus infection. The developed complex of anti-epidemic measures in the provision of emergency and planned ophthalmological care to residents of the Far Eastern Federal District made it possible in 100% of cases to fulfill the state task for the provision of high-tech medical care
Possibilities of surgical treatment of synchronous colon and stomach cancer in a 77-year-old patient
Authors:   Stupino Regional Clinical Hospital, Kovalenko V.L. , Stepochkin A.V. ,   Stupino Regional Clinical Hospital
Published: November 2021

The possibilities of performing simultaneous surgery for synchronous colon and stomach cancer in a 77-year-old patient are presented
Biofilms as a complication of the hyaluronic acid contouring procedure in cosmetology. A clinical case
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Shchetkina M.V.
Published: November 2021

Biofilms are a complication of the hyaluronic acid contouring procedure in cosmetology. A clinical case of complications of the contouring plastic surgery procedure against the background of chronic tonsillitis is described
Middle lobe syndrome: a clinical case
Authors:   Postgraduate Institute for Public Health Workers under Health Ministry of Khabarovsk Krai, Yanchuk V.P.
Published: November 2021

The term of middle lobe syndrome refers to abnormal processes that lead to the fact that due to external pressure and changes in the state of tissues, the airways are narrowed. Plain radiography in two projections is the basic method of radiological examination of patients with suspected "pneumonia" of the middle lobe. The disease develops in 6% of people with lung disorders. Middle lobe syndrome is an inconclusive clinical and radiological diagnosis. It requires clarification of the abnormal process
СПОГАДИ Ф. І. ЄЛІСЄЄВА – ДЖЕРЕЛО ВИВЧЕННЯ ВОЄННОГО МИСТЕЦТВА КУБАНСЬКОЇ КОЗАЦЬКОЇ КІННОТИ ПІД ЧАС АНТИБІЛЬШОВИЦЬКОГО ПОВСТАННЯ У КАВКАЗЬКОМУ ВІДДІЛІ ВЕСНОЮ 1918 р
Authors: Задунайський Вадим Васильович
Published: November 2021

Під час повстання кубанських козаків проти більшовицького режиму в Кавказькому відділі весною 1918 р. важливу роль відіграла кавалерія. Дуже цінним джерелом для вивчення воєнного мистецтва козацької кавалерії під час цього повстання є мемуари талановитого козацького офіцера-кавалериста Ф. І. Єлісєєва (командував усією кавалерією повстанців). Воєнне мистецтво козацької кавалерії під час повстання мало сильні сторони: козаки дуже гарно вели кінний бій; вони могли діяти й у пішому строю; козаки застосували 20 стратегем (частково 1); якісно діяла козацька передова сторожа під час нічного наступу. Недоліки: не мали кінної артилерії; поразка основних сил повстанців призвела до деморалізації козаків-кавалеристів і їх дезертирства. Попри поразку, козацька кавалерія виявила високий рівень воєнного мистецтва.
БІЛОРУСЬКА СТРАТЕГІЧНА НАСТУПАЛЬНА ОПЕРАЦІЯ (23 ЧЕРВНЯ - 29 СЕРПНЯ 1944 РОКУ): ОРГАНІЗАЦІЯ ВЗАЄМОДІЇ ВІЙСЬК ЧОТИРЬОХ ФРОНТІВ
Authors: Кривизюк Леонід Петрович
Published: November 2021

Аналізується Білоруська стратегічна наступальна операція: обстановка, що склалася на території Білорусії після бойових дій взимку і весною 1944 р.; загальні плани сторін на літньо-осінню кампанію; замисли командувачів фронтів на проведення фронтових операцій і завдання військам; питання взаємодії військ фронтів, загальновійськових армій, рухомих груп, артилерійських і авіаційних з’єднань в ході підготовки та проведення операції і зроблено висновки.
ВІЙСЬКОВА ТА ГРОМАДСЬКА ДІЯЛЬНІСТЬ ВАСИЛЯ ПРОХОДИ У РОКИ ПЕРШОЇ СВІТОВОЇ ВІЙНИ ТА УТВОРЕННЯ УКРАЇНСЬКОЇ ДЕРЖАВИ
Authors: Кравець Наталія Петрівна
Published: November 2021

Стаття присвячена українському військовому, громадсько-політичному діячу,підполковнику Армії Української Народної Республіки (УНР), військовому історикуВасилю Проході. Завдяки його архівно-кримінальній справі та мемуарним працямвідтворено маловідомі сторінки біографії Василя Проходи у роки Першої світовоївійни та періоду Української держави. Ретроспективно висвітлено його пере-бування у таборах військовополонених (Йозефштадт (Йозефів), Ліберці, Брюкс(Мост), Терезієнштадт (Терезін). Наголошено, що важливим етапом у йогобіографії стала участь у формування дивізії Сірожупанників. Показано баченняВасиля Проходи щодо розв’язання «українського питання» у роки Першоїсвітової війни, висвітлено його ставлення до зовнішньої, внутрішньої політикигетьмана Павла Скоропадського.
УКРАЇНА – НАТО: ІСТОРІЯ ВІДНОСИН ТА ЗЛАМ СТЕРЕОТИПІВ В УКРАЇНСЬКОМУ СУСПІЛЬСТВІ ЩОДО АЛЬЯНСУ
Authors: Перемибіда Денис Олександрович , Пастухов Віктор Вікторович
Published: November 2021

У статті розглядається історичний аспект зміни суспільно-політичної думки щодо співпраці України з Організацією Північноатлантичного альянсу, злам нав’язаних радянською владою та російським інформаційним втручанням стерео­типів щодо НАТО та участі Збройних Сил України у спільних миротворчих операціях. На підставі документальних даних доведено, що політика української влади щодо відносин з НАТО не була послідовною, а українське суспільство тривалий час перебувало в полоні колишніх уявлень про цю безпекову органі­зацію. В умовах триваючої агресії Російської Федерації воєнно-технічна, матері­альна, експертна допомога НАТО дуже важлива для України. Нові підходи до забезпечення ефективних гарантій суверенітету, територіальної цілісності та зміцнення обороноздатності країни вимагають активного співробітництва між нашою державою та Альянсом.
Economic and legal aspects of the use of computer programs
Authors: Borko Yuliia
Published: November 2021

Keywords: computer program, economic and legal regulation, taxation, licenseagreement, initial cost, value added tax, royalties

The article deals with the economic and legal aspects of using computer programs inbusiness operations. In particular, certain problems of taxation relating to the creationand use of computer programs are considered. There have been consideredways and means of representations in the accounting of the following operations: purchaseof intellectual property rights to a computer program, supply of a computer programfrom a non-resident (resident) to a resident. The principles of the formation ofthe cost of a computer program, depending on the terms of purchase, have been outlined.The has been defined the concept of royalties from the use of a computer programin the economic activity of an enterprise. The article indicates that the supply ofservices (performance of work) related to software products and that introducechanges to the software are deemed to be any updates, changes, additions to expandtheir functionality. Such an operation is referred to as the supply of software productsusing IT benefits. The supply of services that do not introduce changes, namely: installation,configuration, testing, identification and rectification of deficiencies, information,and consulting support is referred to operations that are subject to VAT atthe general rate. The article states that VAT is charged on operations for the supplyof software products from a non-resident (resident) to a resident in the customs territory(customs territory) of Ukraine, which, in turn, is not subject to VAT. At the sametime, if as a result of the provision of technical support services for software products(including software products provided for use under the license agreement) there areno changes in software products (for example, training staff to work with the program,installing the program, configuration of office equipment, etc.), then operationsfor the provision of such services are subject to VAT in the generally established mannerin the amount of 20 percent.There has been determined the need to improve economic and legal regulation ofthe creation and use of computer programs in the economic activities of companies interms of taxation.
INFLUENCE OF THE SURFACE ATMOSPHERIC LAYER POLLUTION ON THE CADASTRAL COST OF LAND PLOTS FOR PRIVATE HOUSING CONSTRUCTION WITHIN THE BOUNDARIES OF THE FEDERAL ROAD "TAVRIDA" TERRITORIES
Authors:   Agrotechnological Academy V. I. Vernadsky Crimean Federal University, Melnichuk Aleksandr Yu. , Antonenko Ekaterina V. ,   Agrotechnological Academy V. I. Vernadsky Crimean Federal University
Published: November 2021

Environmental problems of transport impact on the natural environment in Russia do not lose their relevance. Automobile transport is the leading source of environmental pollution, and the amount of emissions can reach 90 %. These processes are actively manifested within the boundaries of the influence of high-traffic roads. Thus, the tasks of taking into account the pollution level of the surface atmospheric layer in order to clarify the cadastral value of lands located within the boundaries of road-side territories acquire particular relevance. The work used mathematical models to calculate the emission power and surface concentrations of the pollutant (Gaussian atmospheric diffusion model). The interpolation method was used to determine the correction factors for different zones of pollution with carbon monoxide. The authors considered the carbon monoxide pollution density of the roadside territories and stated that the part of federal road "Tavrida" (settlement Zuia) has 121 land plots on the higher-polluted territory, which have the permitted use of "private housing construction" (PHC), there-fore it is considered necessary to correct their cadastral cost taking into account air pollution. The obtained results allows to clarify the local correction coefficients used in the cadastral assessment of roadside territories.
OPTIMIZATION OF SMALL-SCALE LAND USE
Authors:   Saint-Petersburg State Agrarian University, Pavlova Victoria A.
Published: November 2021

In the course of the work on the presented study, the scientific works of leading scientists in the field of land management were analyzed. In the course of their analysis, it was determined that the leading role in the development of the agro-industrial complex and the formation of new relations in rural areas belongs to agriculture. Accordingly, to ensure the proper functioning of small agricultural producers, it is necessary to solve the problem of optimizing their land use. The authors believe that one of the key positions in optimizing the use of territories should be played by "smart land use" and the process of its creation. The paper reveals the process of determining the most significant factors in the formation and functioning of small forms of management, since it is small forms of management that are the most flexible and easily adaptable to the rapidly changing modern economic, legal and so-cial conditions.The evidence base was a statistical analysis of the formation and development of small forms of agriculture of the Russian Federation on a number of indicators: the composition of land, agricultural production, area. The authors propose to identify several groups of factors that affect the optimal parameters of land use. Groups of factors are designated as limiting, optimizing, and support-ing. The study also determined the weights of factors that affect the optimal size of land use within each group using the hierarchy analysis method. The proposed factors and the identified dependencies are embedded in the "smart land use" model.
ASSESSMENT OF THE MODERN GEODYNAMIC SITUATION AT TASHTAGOL IRON ORE DEPOSIT
Authors:   Siberian State University of Geosystems and Technologies, Mazurov Boris T. , Lobanova Tatiana V. ,   Siberian State Industrial University, Elshina Tatiana E. ,   Siberian State University of Geosystems and Technologies, Abzhaparova Dinara A. ,   Osh State University
Published: November 2021

The results of GNSS observations in the area of protected objects in the mining influence zone are presented. For research, the Northwest section of the Tashtagol iron ore deposit was selected. This is the largest field in the Mountain Shoria. Directly in the area of the mine there is a sinkhole. This makes monitoring difficult. An analysis of the displacements of the earth's surface under anthropogenic im-pact is carried out. The finite element method and the model of locally uniform deformation of a triangular finite element were used. Surfer and Elcut software packages were used to determine the parameters of the deformation fields and their visualization. The article shows the change in shape and boundary, displacement and dilatation fields, deformation field along the x axis and deformation field along the y axis. The research results will help to substantiate an expert assessment of the geodynamic situation of the Tashtagol iron ore deposit at present and to make a reasonable forecast of the deformation situation of the deposit territory. This justifies the relevance of regularly conducted geodetic observations, which are also of environmental importance and industrial safety.
CONTENT AND PRACTICE OF DIGITAL INFORMATION SPACE CREATION FOR AUTOTRANSPORT INFRASTRUCTURE
Authors:   Industrial University of Tyumen, Budarova Valentina A. , Martynova Natalia G. ,   Industrial University of Tyumen, Sheremetinskiy Artem V. ,   Industrial University of Tyumen
Published: November 2021

The purpose of the work is the relevant problem of formation of digital information space for transport infrastructure. The object of the research is the part of the automobile road, connecting the cities of KhMAD and YNAO: Surgut and Salekhard situated in the Arctic zone of Russia. On the given part Purpe-Purovsk km 494+650 – km 507+200 in the process of preliminary works there was per-formed a significant project-related volume of prospecting and special measuring works (by means of ground-based laser scanner Leica Nova MS60) for creation of digital model for this part of the road together with adjacent territory and objects on it. As a result of performed works there has been developed the method of production (of special working process) of engineering explorations and data processing obtained with the use of ground-based laser technology (GLT), which provides the formation of digital information space of the federal road, information requirements of its exploitation, real estate maintenance and its possible reconstruction and future repairing. The technology can be applied in the development of the transport cores of the Russian Federation. Practical results of GLT application demonstrate its reliability and expediency in the specified conditions when carrying out such works.
INDEX OF FIELD SURVEY OF THE TERRITORY FOR MEDIUM-SCALE MAPPING
Authors:   Institute of Soil Science and Agrochemistry SB RAS, Makhatkov Igor D.
Published: November 2021

The quality of thematic mapping mostly depends on the representativeness of the field survey of the territory. In large-scale mapping geostatistical techniques can be used to design survey spatial sampling. In medium-scale mapping, the sampling scheme is traditionally based on experience, common views about the thematic diversity of the territory and available cartographic data. In the digital map-ping of thematic variables secondary data is used. There are mainly remote sensing data and derivatives of a digital elevation model. Spatial extrapolation of thematic information of points is somehow connected with the use of distance measures between studied and unstudied points in the space of secondary variables. This measure is proposed to be used as a numerical measure of the survey quality of the entire mapping space. This article provides numerical experiments to illustrate the behavior of this index, as well as proposes possible ways of using the index to control fieldwork in order to improve the spatial model of thematic variables.
ANALYSIS OF THE STATE AND TRENDS OF SPATIAL DATA VISUALIZATION
Authors:   Siberian State University of Geosystems and Technologies, Molokina Tatyana S. , Kolesnikov Aleksey A. ,   Siberian State University of Geosystems and Technologies
Published: November 2021

The growth of information technology has led to a significant expansion of the possibilities for storing, processing and presenting spatial data. This gave a new round of development to such a direction of cartography and geoinformatics as geovisualization. Interactivity and dynamics have become the main distinguishing features of modern maps, especially in the field of cartographic design, which now extend to the problems of human-computer interaction to ensure more successful analysis of geodata and the development of spatial solutions. The article examines the existing definitions of geovisualization and proposes its own version. The scheme and features of individual stages of geovisualization creation are considered. Typical tasks that need to be solved to create high-quality visualization of spatial data are formulated and their systematization is performed. On the basis of the mentioned above tasks and their specificity, the most promising areas of research in the field of geovisualization were identified.
Clinical, zootechnical and behavioral evaluation of litters of dogs born in the guide dog program of the ‘Instituto Federal Goiano’, Campus Urutaí, Brazil
Authors: Silva Laura Bruna Aparecida , Naves Brunno Moreira , Oliveira Kellen de Souza , Carvalho Rosângela de Oliveira Alves , Carmo Adriana Santana do , Filho Saulo Humberto de Ávila
Published: November 2021

The Brazilian population with low vision or blindness is approximately six and a half million people. This scenario is intricate because of the existence of only six Guide Dog Training Centers and, consequently, few Guide Dogs performing the role of assistive therapy as a guide for blind people in Brazil. The objective was to comparatively characterize the clinical, zootechnical, and behavioral profile of three litters of dogs born at the Guide Dog Training Center of the Federal Institute of Goiás, Campus of Urutaí, Brazil, from conception to the forty-ninth day of life. The number of live births, stillbirths, average daily weight gain, the incidence of congenital diseases, and acquired diseases were surveyed. The performance of puppies obtained in the Volhard and Behavior Checklist tests was also obtained. Litter B presented higher stillbirths. A higher average daily weight gain was also observed in litter B and, consequently, a higher weight of pups at all evaluation moments. Litter E differed from the others regarding the behavioral parameters, showing better results in terms of hyper-attachment, fear of strangers, and anxiety in unknown places. Therefore, a difference was observed between litters regarding the evaluated zootechnical and behavioral aspects. Furthermore, an evolution was observed over time, with the last litter, whose parents were animals from the kennel, presenting the best behavioral profile.
Construction of an Acetate Metabolic Pathway to Enhance Electron Generation of Engineered Shewanella oneidensis
Authors: Zhang Junqi , Chen Zheng , Liu Changjiang , Li Jianxun , An Xingjuan , Wu Deguang , Sun Xi , Zhang Baocai , Fu Longping , Li Feng , Song Hao
Published: November 2021

Background: Microbial fuel cells (MFCs) are a novel bioelectrochemical devices that can use exoelectrogens as biocatalyst to convert various organic wastes into electricity. Among them, acetate, a major component of industrial biological wastewater and by-product of lignocellulose degradation, could release eight electrons per mole when completely degraded into CO2 and H2O, which has been identified as a promising carbon source and electron donor. However, Shewanella oneidensis MR-1, a famous facultative anaerobic exoelectrogens, only preferentially uses lactate as carbon source and electron donor and could hardly metabolize acetate in MFCs, which greatly limited Coulombic efficiency of MFCs and the capacity of bio-catalysis.

Results: Here, to enable acetate as the sole carbon source and electron donor for electricity production in S. oneidensis, we successfully constructed three engineered S. oneidensis (named AceU1, AceU2, and AceU3) by assembling the succinyl-CoA:acetate CoA-transferase (SCACT) metabolism pathways, including acetate coenzyme A transferase encoded by ato1 and ato2 gene from G. sulfurreducens and citrate synthase encoded by the gltA gene from S. oneidensis, which could successfully utilize acetate as carbon source under anaerobic and aerobic conditions. Then, biochemical characterizations showed the engineered strain AceU3 generated a maximum power density of 8.3 ± 1.2 mW/m2 with acetate as the sole electron donor in MFCs. In addition, when further using lactate as the electron donor, the maximum power density obtained by AceU3 was 51.1 ± 3.1 mW/m2, which approximately 2.4-fold higher than that of wild type (WT). Besides, the Coulombic efficiency of AceU3 strain could reach 12.4% increased by 2.0-fold compared that of WT, which demonstrated that the engineered strain AceU3 can further utilize acetate as an electron donor to continuously generate electricity.

Conclusion: In the present study, we first rationally designed S. oneidensis for enhancing the electron generation by using acetate as sole carbon source and electron donor. Based on synthetic biology strategies, modular assembly of acetate metabolic pathways could be further extended to other exoelectrogens to improve the Coulombic efficiency and broaden the spectrum of available carbon sources in MFCs for bioelectricity production.
Repurposing Combination Therapy of Voacamine With Vincristine for Downregulation of Hypoxia-Inducible Factor-1α/Fatty Acid Synthase Co-axis and Prolyl Hydroxylase-2 Activation in ER+ Mammary Neoplasia
Authors: Singh Lakhveer , Roy Subhadeep , Kumar Anurag , Rastogi Shubham , Kumar Dinesh , Ansari Mohd. Nazam , Saeedan Abdulaziz S. , Singh Manjari , Kaithwas Gaurav
Published: November 2021

Graphical Abstract

Mechanism of VOA and VIN to inhibit fatty acid synthesis in DMBA-induced mammary gland carcinoma of albino Wistar rats. Hypoxia-activated HIF-1α enhances lactate acidosis in the tumor microenvironment, and dysregulated pH in the tumor microenvironment activates SREBP-1c and FASN expression to speed up the fatty acid synthesis required for plasma membrane synthesis in rapidly proliferating cells. VOA- and VIN-activated PHD-2 enhanced the proteolytic degradation of HIF, thus inhibiting fatty acid synthesis. HIF-1α, hypoxia-inducible factor-1α; SREBP-1c, sterol regulatory element-binding protein-1c; FASN, fatty acid synthesis; PHD-2, prolyl hydroxylase-2.
Unraveling the Effect of Aromatic Groups in Mn(I)NNN Pincer Complexes on Carbon Dioxide Activation Using Density Functional Study
Authors: Parmar Saurabh Vinod , Avasare Vidya , Pal Sourav
Published: November 2021

Carbon dioxide utilization is necessary to reduce carbon footprint and also to synthesize value-added chemicals. The transition metal pincer complexes are attractive catalysts for the hydrogenation of carbon dioxide to formic acid. There is a need to understand the factors affecting the catalytic performance of these pincer complexes through a structure–activity relationship study using computational methods. It is a well-established fact that aromatic functionalities offer stability and selectivity to transition metal catalysts. However, their impact on the performance of the catalysts is lesser known in the case of metal pincer complexes. Hence, it is necessary to investigate the catalytic performance of Mn(I)NNN pincer complexes with variably activated aromatic functionalities. In this context, 15 catalysts are designed by placing different types of aromatic rings at the pincer carbons and two terminal nitrogen of Mn(I)NNN pincer complexes. A benzene moiety, placed at C2–C3 carbons of Mn(I)NNN pincer complex with identical aromatic groups at the terminal nitrogen, is found to be most efficient toward CO2 hydrogenation than the rest of the catalysts. On the other hand, when N,N-dimethyl aniline is placed at C2–C3 carbons of Mn(I)NNN pincer complexes, then the catalytic performance is significantly decreased. Thus, the present study unravels the impact of aromatic groups in Mn(I)NNN pincer complexes toward the catalytic hydrogenation of carbon dioxide.
Predictions of the Climate Change-Driven Exodus of the Town of Tangier, the Last Offshore Island Fishing Community in Virginia's Chesapeake Bay
Authors: Wu Zehao , Schulte David
Published: November 2021

Sea-level rise (SLR) has been confirmed to be accelerating globally due to human-influence driven climate change. Multiple studies suggest many coastal communities will soon be inundated by SLR. Prior to inundation, habitable uplands above the high tide line first convert to uninhabitable wetlands, forcing human exodus. Habitability, not the land's presence above the low tide line, drives exodus. We determined the time left for uplands of the Town of Tangier of VA, USA to be converted to wetlands, analyzed local sea level rise data to determine the best local SLR scenario (low, mid, or high) fit, then compared upland conversion rate to the rate of population decline. The upland landmass constituting the Town of Tangier declined from 32.8 to 12.5 ha (1967–2019), accelerating over time, with complete conversion to wetlands predicted by 2051. The US Army Corps of Engineers (USACE) high SLR curve is the best fit to the local tide gauge's raw data (1967–2020), indicating local sea level rise has rapidly accelerated in recent decades, concomitant with the rate of wetland conversion. The Town's population, in decline since the 1930s, accelerated rapidly after 1980 and trended downward in tandem with the conversion of the Town's uplands to wetlands. We also estimated costs to relocate the Town as well as for a conceptual plan to provide long-term stability to the Town and Island of Tangier.
Genetic Approach on Sanionia uncinata (Hedw.) Loeske to Evaluate Representativeness of in situ Conservation Areas Among Protected and Neighboring Free Access Areas in Maritime Antarctica and Southern Patagonia
Authors: Hebel Ingrid , Gonzalez Inti , Jaña Ricardo
Published: November 2021

The Antarctic Specially Protected Areas (ASPAs) are zones with restricted access to protect outstanding environmental, scientific, historic, aesthetic, or wilderness values adopted inside the Antarctic Treaty System. Meanwhile, in southern Patagonia, conservation initiatives are implemented by the state of Chile and private entities. However, both are considered unrepresentative. Our work evaluates the representativeness of thein situconservation through a genetic approach of the mossSanionia uncinata(Hedw.) Loeske among protected and neighboring free access areas in Maritime Antarctica and southern Patagonia. We discuss observed presence with both current and reconstructed past potential niche distributions (11 and 6 ka BP) in the Fildes Peninsula on King George Island. Results showed occurrence of several spatially genetic subpopulations distributed inside and among ASPA and free access sites. Some free access sites showed a higher amount of polymorphism compared with ASPA, having ancestry in populations developed in those places since 6 ka BP. The different spatial and temporal hierarchies in the analysis suggest that places for conservation of this species in Maritime Antarctica are not well-represented, and that some free access areas should be considered. This work represents a powerful multidisciplinary approach and a great challenge for decision-makers to improve the management plans and the sustainable development in Antarctica.
Association Between Serum Cystatin C and Thyroid Diseases: A Systematic Review and Meta-Analysis
Authors: Xin Caihong , Xie Jing , Fan Huaying , Sun Xin , Shi Bimin
Published: November 2021

Background

Cystatin C (CysC) is often used to diagnose and monitor renal diseases. Although some studies have investigated the association between serum CysC levels and thyroid diseases, their reported results were inconsistent. Therefore, the relationship between CysC levels and thyroid diseases remains controversial.

Aim

This meta-analysis aimed to statistically evaluate serum CysC levels in patients with thyroid diseases.

Methods

A literature search was conducted using the PubMed, Web of Science, Embase, EBSCO, andWiley Online Librarydatabases. The following search terms were used for the title or abstract: “Cystatin C” or “CysC” in combination with the terms “thyroid disease”, “thyroid function”, “hypothyroidism”, or “hyperthyroidism”. The results of the systematic analysis were presented as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs).

Results

Eleven articles (1,265 cases and 894 controls) were included in the meta-analysis. The results of the meta-analysis showed that the serum CysC levels of patients with hyperthyroidism were significantly higher than those of the controls (SMD: 1.79, 95% CI [1.34, 2.25]), and the serum CysC levels of patients with hypothyroidism were significantly lower than those of the controls (SMD −0.59, 95% CI [−0.82, −0.36]). Moreover, the treatment of thyroid diseases significantly affected serum CysC levels.

Conclusions

To the best of our knowledge, this meta-analysis is the first to evaluate serum CysC levels in patients with thyroid diseases. Our findings suggest that thyroid function affects serum CysC levels and that serum CysC may be an effective marker for monitoring thyroid diseases.

Systematic Review Registration

PROSPERO [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=258022], identifier CRD42021258022].
The Effect of Early vs. Deferred Antiretroviral Therapy Initiation in HIV-Infected Patients With Cryptococcal Meningitis: A Multicenter Prospective Randomized Controlled Analysis in China
Authors: Zhao Ting , Xu Xiao-lei , Lu Yan-qiu , Liu Min , Yuan Jing , Nie Jing-Min , Yu Jian-Hua , Liu Shui-qing , Yang Tong-Tong , Zhou Guo-Qiang , Liu Jun , Qin Ying-Mei , Chen Hui , Harypursat Vijay , Chen Yao-Kai
Published: November 2021

Background: The optimal timing for initiation of antiretroviral therapy (ART) in HIV-positive patients with cryptococcal meningitis (CM) has not, as yet, been compellingly elucidated, as research data concerning mortality risk and the occurrence of immune reconstitution inflammatory syndrome (IRIS) in this population remains inconsistent and controversial.

Method: The present multicenter randomized clinical trial was conducted in China in patients who presented with confirmed HIV/CM, and who were ART-naïve. Subjects were randomized and stratified into either an early-ART group (ART initiated 2–5 weeks after initiation of antifungal therapy), or a deferred-ART group (ART initiated 5 weeks after initiation of antifungal therapy). Intention-to-treat, and per-protocol analyses of data for these groups were conducted for this study.

Result: The probability of survival was found to not be statistically different between patients who started ART between 2–5 weeks of CM therapy initiation (14/47, 29.8%) vs. those initiating ART until 5 weeks after CM therapy initiation (10/55, 18.2%) (p = 0.144). However, initiating ART within 4 weeks after the diagnosis and antifungal treatment of CM resulted in a higher mortality compared with deferring ART initiation until 6 weeks (p = 0.042). The incidence of IRIS did not differ significantly between the early-ART group and the deferred-ART group (6.4 and 7.3%, respectively; p = 0.872). The percentage of patients with severe (grade 3 or 4) adverse events was high in both treatment arms (55.3% in the early-ART group and 41.8% in the deferred-ART group; p=0.183), and there were significantly more grade 4 adverse events in the early-ART group (20 vs. 13; p = 0.042).

Conclusion: Although ART initiation from 2 to 5 weeks after initiation of antifungal therapy was not significantly associated with high cumulative mortality or IRIS event rates in HIV/CM patients compared with ART initiation 5 weeks after initiation of antifungal therapy, we found that initiating ART within 4 weeks after CM antifungal treatment resulted in a higher mortality compared with deferring ART initiation until 6 weeks. In addition, we observed that there were significantly more grade 4 adverse events in the early-ART group. Our results support the deferred initiation of ART in HIV-associated CM.

Clinical Trials Registration:www.ClinicalTrials.gov, identifier: ChiCTR1900021195.