bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemphigus: an epidemiological study of patients treated in Finnish hospitals between 1969 and 1978
Authors: Hietanen J. , Salo OP.
Published: August 2023

Between 1969 and 1978, 44 pemphigus (p.) patients were treated in Finnish hospitals. The number of new cases was 36, giving an annual incidence of 0.76 cases per million inhabitants. The male/female ratio was 0.9:1. Nine patients had p. vulgaris (p.vu.); one p. vegetans (p.ve.); 9, p. foliaceus (p.fo.); 22, p. erythematodes (p.er.); and 3, p.NUD (p.NUD). One patient with p.er. also had myasthenia gravis. The mean age at onset was 57 1/2 years. The disease started in the mouth only in p.vu. (78% of cases) and in p.NUD (67%). Prednisone (or its derivatives) was most commonly used for systemic treatment, the mean initial dose being 61.4 mg/day. P.vu. and p.NUD required higher initial doses of prednisone and a longer duration of the high-dose treatment. The smallest mean daily dose of prednisone required to achieve a remission of at least 6 months was 5.2 mg. The mean duration of remission was 30 1/2 months. The frequency of side effects of systemic drug therapy was low (18%), possibly because only comparatively low doses of prednisone were used in Finland. The cause of death in 3 (6.8%) out of 44 patients was attributable either to p. itself or to its treatment. The mean annual number of hospitalization days for the whole material was 16.4 days and the mean annual number of hospital admissions 0.7.
Lack of lysozyme, alpha 1-antitrypsin and alpha 1-antichymotrypsin in normal Langerhans´ cells: differentiation from cells of the monocyte-histiocyte-macrophage series
Authors: Holden CA. , Kerdel FA. , MacDonald DM.
Published: August 2023

No abstract available.
Lymphocytotoxic autoantibodies in pemphigus and systemic lupus erythematosus
Authors: Furukawa F. , Imamura S. , Inoue S. , Yoshida H. , Hamashima Y.
Published: August 2023

Lymphocytotoxic autoantibody (LCTA) was studied in 9 patients with active pemphigus and 19 patients with active systemic lupus erythematosus (SLE). All patients with SLE showed high titres of LCTA but only one patient with pemphigus had LCTA. In this paper we discuss the immunological significance of LCTA and the difference in the incidence of LCTA between pemphigus and SLE. In addition we present the clinical features of the case with LCTA-positive pemphigus and suggests that the presence of LCTA is due to the common viral infection.
Sensitization to cobalt associated with nickel allergy: clinical and statistical studies
Authors: Van Joost T.  , Van Everdingen
Published: August 2023

In 76 cases (5.8%) of a population of 1310 cases (examined by patch tests for possible contact dermatitis) a combined (coupled) allergy was found to nickel and cobalt. In 37 out of the 76 cases this combined allergy was associated with clinical dermatitis of the hands. Statistical chi-square analysis revealed that in the original population of patients examined, apart from a strong association between nickel and cobalt reactions, a significant association was also seen extending to the actual level (weakly to strongly positive) of reactions. Moreover this statistically significant association was still seen within the restricted population of combined nickel and cobalt allergics. Statistical association within the population of combined nickel and cobalt allergy between the strength of the Ni and Co reactions and positive reactions to other antigens of routine ICDRG-standard battery was not encountered, however. Positive reactions to cobalt were rare, but extreme. Nickel patients appeared to have about 50 times greater odds of being extreme cobalt positive. The possibility is discussed that facilitation of clinical cobalt allergy might be triggered by a high grade of nickel sensitivity.
Actinic granulomas and relapsing polychondritis
Authors: Pierard GE. , Henrijean A. , Foidart JM. , Lapiere CM.
Published: August 2023

A patient developed concomitantly chondritis of the two auricles, diffuse cutaneous vasculitis and actinic granulomas. Alterations in skin and cartilage were prominent in the elastic tissue. Anticollagen type II antibodies were absent from the serum and there was no deposit of immunoreactants in cartilages. In this form of relapsing polychondritis, the pathomechanism resembles that of diffuse actinic arteritis as proposed by O´Brien. It is concluded that relapsing polychondritis may represent a heterogeneous syndrome with regard to its pathogenesis.
Delusions of infestation treated by pimozide: a double-blind crossover clinical study
Authors: Hamann K. , Avnstorp C.
Published: August 2023

Eleven patients with delusions of infestation were treated with pimozide using a double-blind crossover technique. Ten out of 11 patients improved. The investigation showed significant relief of itch and delusions during pimozide treatment. Brief Psychiatric Rating Scale (BPRS) points decreased significantly. Adverse effects were few by 2 patients showed dose-related depressive reactions during treatment. Pimozide treatment of patients with delusions of infestation should be entrusted to dermatologists, because these patients with delusions differ from most patients attending psychiatric clinics in that they have a monosymptomatic hypochondriacal psychosis.
Banded structure in solitary trichoepithelioma
Authors: Ono T. , Sakazaki Y. , Jono M. , Muto K.
Published: August 2023

Electron microscopical observations were made in a case of solitary trichoepithelioma. Enlarged ERs were found in the tumor cells, showing a peculiar structure with fine granules and an electron-dense banded structure, about 50 nm wide respectively, lying at intervals of 250 nm. In addition to this structure, dense ovoid bodies, about 500 to 600 nm in diameter, were also observed.
The influence of PUVA treatment on the substructure of nevocellular nevi in psoriatic patients
Authors: Lagerholm B. , Frithz A.
Published: August 2023

The influence of PUVA treatment on junction A-cell nevi in psoriatic patients has been analysed. After long-term PUVA therapy the nevocytes display an obvious increase in melanosome synthesis. The melanosomes are clearly polymorphous, without any predominant configuration. The structural organization of the melanosomes is profoundly aberrant. Formation of autophagosomes is conspicuous. The cytoplasmic filaments are displaced peripherally. No convincing signs of malignancy are observed electron microscopically. Light microscopical findings of a bridging proliferation of nevocytes between junction nests is a precautionary observation, however.
Generalized morphoea successfully treated with salazopyrine
Authors: Czarnecki DB. , Taft EH.
Published: August 2023

A patient with active, generalized morphoea was treated successfully with salazopyrine on two occasions. The first time the trunk was involved and most of the skin softened after the drug therapy was started. After salazopyrine was discontinued, morphoea developed in the thighs but recommencement of therapy resulted in complete resolution.
Retinoid acid in the treatment of hyperkeratosis lenticularis perstans Flegel
Authors: Lindemayr H. , Jurecka W.
Published: August 2023

No abstract available.
In situ characterization and counting of mononuclear cells in lesions of different clinical forms of psoriasis
Authors: Bjerke JR.
Published: August 2023

Mononuclear cells in the dermis were characterized and counted in cryostat sections of lesional skin from 34 patients with various clinical forms of psoriasis. T lymphocytes were detected with F(ab´)2 preparation of rabbit IgG against human T lymphocytes and acid alpha-naphthyl acetate esterase (ANAE) activity as histochemical marker. The ANAE method was also used for the detection of macrophages. Comparable results were obtained using both the anti-T lymphocyte serum method and the ANAE method. The highest proportion of ANAE-positive lymphocytes was found in sections from stationary lesions of psoriasis vulgaris (61.2%), and the lowest in lesions of erythroderma (38.5%). ANAE-positive macrophages constituted 51.3% of the mononuclear cells in lesions of erythroderma and 29.7% in stationary lesions of psoriasis vulgaris. Only a few B lymphocytes could be detected with goat antibodies against human Fab of Ig. Cells with receptors for the Fc part of IgG (FcR) were detected using soluble complexes of horseradish peroxidase (HRP-anti-HRP. Most FcR-positive cells were found in lesions of pustular psoriasis (53.7%) and in erythroderma (45.5%), and fewest (18.3%) in stationary lesions of psoriasis vulgaris.
Demonstration of Ia-like antigens on T lymphocytes in lesions of psoriasis, lichen planus and discoid lupus erythematosus
Authors: Bjerke JR. , Matre R.
Published: August 2023

A combined indirect immunofluorescence technique with a murine monoclonal antibody against human Ia-like antigens (OKIal) and an IgG F(ab´)2 preparation of a rabbit anti-T lymphocyte serum was used to study Ia-like antigens on T lymphocytes in skin lesions of psoriasis, lichen planus and discoid lupus erythematosus. The majority of the T lymphocytes in the various skin lesions expressed Ia-like antigens. T lymphocytes expressing Ia-like antigens were also demonstrated in the dermis and the epidermis in sections of unaffected skin, although of a markedly lower proportion than in affected skin. The results may indicate that the T lymphocytes in these skin lesions are activated cells involved in cell-mediated immune reactions.
The effect of UVB light on serum concentrations of 5-S-cysteinyldopa
Authors: Tegner E. , Agrup G. , Rosengren E.
Published: August 2023

No abstract available.
Segmental pigmentation disorder
Authors: Metzker A. , Morag C. , Weitz R.
Published: August 2023

Pigmentary changes with a dermatomal distribution are described in 30 children. The disorder, up to now unrecognized as an entity, is apparently caused by an embryological determination. It is more obvious in children with darker skin, and seems to fade very slowly over the years. In our experience the incidence is 0.35%. No relation to other anomalies could be established.
Purpura with a linear epidermo-dermal deposition of IgA
Authors: Väätäinen N. , Fräki JE. , Hyvönen M. , Neittaanmäki H.
Published: August 2023

A patient suffering from purpura is reported, having persistent linear deposition of IgA along the basement membrane zone in both lesional and healthy skin. The ordinary histopathology showed the picture of purpura pigmentosa with perivascular lymphocytes, polymorphonuclear cells and extravasated erythrocytes. No blisters have been observed.
Nail bed immunofluorescence in pemphigus vulgaris
Authors: Fulton RA. , Campbell I. , Carlyle D. , Simpson NB.
Published: August 2023

No abstract available.
Primary macroglobulinemia presenting as multiple ulcers of the legs
Authors: Nishijima S. , Hosokawa H. , Yanase K. , Asada Y. , Fujinami S.
Published: August 2023

Multiple ulcers developed on the lower legs of a 67-year-old man suffering from macroglobulinemia. Histological and direct immunofluorescence studies on biopsy specimens taken from the lesions revealed dilation of capillaries, deposition of large quantities of IgM in the vessels, and deposition of C3 in the vessel walls. A marked increase in blood Clq binding immune complexes was also noted. These findings suggest immune complex-induced ulceration. The fact that IgM-type cryoglobulins were positive implies that cryoglobulins derived from macroglobulins may play an important causative role in ulceration.
Atopic dermatitis and Hodgkin´s disease
Authors: Winkelmann RK. , Rajka G.
Published: August 2023

No abstract available.
Herpes zoster in a 6-month-old infant
Authors: Helander I. , Arstila P. , Terho P.
Published: August 2023

No abstract available.
The cellular infiltrate of the contact sensitivity reaction to picryl chloride in the mouse
Authors: Bäck O. , Groth O.
Published: August 2023

Contact sensitivity to picryl chloride was studied in the mouse ear. The skin hypersensitivity, as a factor of ear swelling, and the intensity of the cellular infiltrate in the skin were evaluated together during the elicitation of the contact sensitivity reaction. It was found that the ear swelling is a mainly vascular reaction preceding the appearance of inflammatory cells. The infiltrating cells in this model of skin sensitivity were differentiated in Giemsa-stained plastic-embedded sections and recorded in a semi-quantitative way. When the cellular reaction was most intense at 48 and 72 hours after challenge, the most numerous inflammatory cells were lymphocytes and eosinophils.
Nerve changes in morphea
Authors: Kobayasi T. , Serup J.
Published: August 2023

Thirty-nine peripheral nerves in dermis of 12 morphea patients were analysed for ultrastructural changes. Changes found in the mesenchymal parts of the nerves, i.e. epi-, peri- and endoneurium, were myxedematous changes, collagen fibril degradation, cell infiltration and abnormal fibrosis. The infiltrating cells were lymphocytes and plasma cells as well as mast cells and myofibroblast. Perineural cells were assumed to be one of the origins of myofibroblasts. The axons and the Schwann cells showed slight signs of degeneration.
Central nervous system involvement in early syphilis. Part 1. Intrathecal immunoglobulin production
Authors: Löwhagen GB. , Andersson M. , Blomstrand C. , Roupe G.
Published: August 2023

The immunological activity in the cerebrospinal fluid (CSF) was studied in 47 patients with early syphilis. The immunoglobulin production within the central nervous system (CNS) was estimated by analysing immunoglobulin G and albumin in CSF and serum and constructing an IgG index according to Tibbling et al. and calculating daily CNS IgG synthesis, according to Tourtellotte. In 10 (21%) of the 47 patients, intrathecal immunoglobulin production was observed. The immunoglobulin production within the CNS was significantly correlated to the presence of syphilis antibodies and to pleocytosis. Eight of the patients demonstrated oligoclonal bands on electrophoresis. Total protein usually did not reveal an increased CNS immunoglobulin production but reflected a blood-brain barrier lesion. One year after penicillin treatment, 2 out of 9 patients still had slight intrathecal immunoglobulin production.
The prevalence of dermatophyte infections in hereditary palmo-plantar keratoderma
Authors: Gamborg Nielsen P.
Published: August 2023

The prevalence of dermatophyte infections in hereditary palmo-plantar keratoderma of the Unna Thost variety was investigated. Sixty patients, who represented 7.5% of a well defined population, participated in the study. The prevalence was found to be about 40%. At the same time the correlation between direct microscopic examination and conventional culture methods was shown to be 88.5%.
Complications in the intralesional injection of triamcinolone acetonide by jet injector (Dermojet)
Authors: Fjellner B. , Herczka O. , Wennersten G.
Published: August 2023

Two patients with lichenified eczematous lesions on the dorsal aspect of the hands were treated intralesionally with triamcinolone acetonide injected with an air-powered high-pressure device, Dermojet. The therapy was complicated by tendon rupture in one patient and by the development of a subcutaneous nodule, which was suspected to be a foreign body granulomatous reaction, in the other patient.
Effect of vasoactive agents on prostanoids in suction blister fluid
Authors: Juhlin L. , Civier A. , Hensby C. , Shroot S.
Published: August 2023

Iontophoresis of histamine in the skin has been shown to release prostaglandins and arachidonic acid in suction blister fluid. Application of DMSO had a similar effect. No effect was found after using the following erythema and oedema irritants: scraping, vibration and ketocaine. Treatment with vasoconstricting drugs such as noradrenaline betamethasone and lidocaine-prilocaine mixture did not influence the prostaglandin or arachidonic acid levels.
Giant basal cell carcinoma with metastasis and secondary amyloidosis: report of case
Authors: Beck HI. , Andersen JA. , Birkler NE. , Ottosen PD.
Published: August 2023

Basal cell carcinoma of the skin is a slow growing relatively benign tumor usually located on the head and neck. Although rare, metastasis to lymph nodes or parenchymatous organs has been reported previously (1-9). We wish to add another case of metastasizing basal cell carcinoma of the skin, which presented certain unique features only rarely reported (1), namely complicating amyloidosis in the kidneys, the lymph nodes, the spleen and probably in the intestinal canal.
Beçhet's syndrome in two brothers
Authors: Aronsson A. , Tegner E.
Published: August 2023

Two brothers, born in 1944 and 1950, had been brought up in separate homes since 1951. In 1978 they were both afflicted with Beçhet's syndrome. This condition is uncommon in Scandinavia, and there are no other known reports of familial cases from the Scandinavian countries. The etiology of the disease is obscure and controversial. In our two cases a hereditary disposition seems more probable than an infectious origin.
Leprosy in Vietnamese refugees: a case report
Authors: Christiansen JV. , Jensen JR. , Søgård H. , Thestrup-Pedersen K.
Published: August 2023

A 41-year-old Vietnamese refugee was found to have tuberculoid leprosy. Dapsone treatment cleared her skin lesion, but did not remove the paraesthesia in the right ulnar nerve. Immunological investigations revealed a strongly positive lepromin test and a significant change in the ratio of T-y and T-mu lymphocytes in peripheral blood. The incidence of leprosy in Vietnamese refugees in Scandinavia is discussed.
White sponge nevus: successful treatment with penicillin
Authors: Alinovi A. , Benoldi D. , Pezzarossa E.
Published: August 2023

White sponge nevus is a rare, benign, inherited disorder of the mucous membranes, affecting mainly the oral mucosa. A case is reported of white sponge nevus, which showed a definite improvement following penicillin administration.
Treatment of the ichthyosis of the Sj√∂gren-Larsson syndrome with etretinate (Tigason)
Authors: Jagell S. , Lidén S.
Published: August 2023

The ichthyosis of seven patients with the Sj√∂gren-Larsson syndrome was treated with an aromatic retinoid, etretinate, during six months. Very good results were registered in six of the patients measured both as clinical improvement and as reduction in quantity of emollients needed. No unexpected side effects were noted.
Irritation and staining by dithranol (anthralin) and related compounds. V. Short-contact and tape-stripping experiments with dithranol and butantrone
Authors: Göransson AM , Kolari PJ , Mustakallio KK.
Published: August 2023

Dithranol (D) and butantrone (BD) were compared as regards irritation and staining in conditions resembling short-contact therapy. Nine psoriatics were tested with 0.5% D and 0.66% BD using exposures of 20 min and 3 h. Partial removal of the horny layer by 15 tape strippings before and after the exposure resembled the impaired barrier of lesions and posttreatment washing, respectively. Development of erythema and staining, and alterations in blood flow were followed for 7 days. In the unstripped skin, D caused after 20 min exposure within 3 days a faint but defined erythema and increase in blood flow, and within 7 days a brownish hue. Irritation was suppressed by stripping after 20 min exposure. After 3 h contact, irrespective of stripping, much stronger irritation and staining developed. BD caused no staining after 20 min of exposure and little if any erythema. After 3 h contact, it caused only minimal staining and markedly less irritation than equimolar D.
Inactivation of human tyrosinase by cysteine. Protection by dopa and tyrosine
Authors: Jergil B , Lindbladh C , Rorsman H , Rosengren E.
Published: August 2023

Human tyrosinase prepared from cultured melanoma cells is inactivated by 10 mM cysteine. The inactivation of the enzyme by cysteine is less pronounced in the presence of catalase and superoxide dismutase. Thus, oxygen radicals and/or hydrogen peroxide may contribute to the inactivation of human tyrosinase by cysteine. Dopa and/or tyrosine protects tyrosinase against inactivation by cysteine. The protection observed with tyrosine alone indicates that oxidation of substrate is not necessary for the protection. The effect of dopa and/or tyrosine is probably due to steric hindrance at the active site preventing the access of cysteine to the copper.
The CHILD-syndrome--congenital hemidysplasia with ichthyosiform erythroderma and limb defects. A case report
Authors: Christiansen JV , Overgaard Petersen H , Søgaard H.
Published: August 2023

A presentation of a 3-year-old girl with a congenital hemidysplasia of the left side together with ichtyosiform erythroderma, the so-called CHILD-syndrome. A short review of the syndrome is given.
Short contact anthralin therapy of psoriasis with and without UV-irradiation and maintenance schedule to prevent relapses
Authors: Brun P , Juhlin L , Schalla W.
Published: August 2023

A short term anthralin application schedule was used at home in 42 patients with severe psoriasis. In another group of 21 patients treated at our day care center, UV-B irradiation was added when the surplus of anthralin had been washed off. Good healing results within 3-8 weeks were noted in most patients. To prevent relapses 31 patients continued the anthralin treatment once or twice a week after healing. In 15 cases this was combined with UV irradiation. One patient relapsed after a severe infection, but 16 others were observed for 6-9 months and 14 for 3-5 months without relapses. Irritation of non-affected skin is common especially at the beginning of the treatment and some staining of clothes and linen can occur. With proper information about this, the treatment is well accepted by the patient who generally finds it reasonably simple without the need of special protective dressings.
Loss of bullous pemphigoid antigen in peritumoral lacunas of basal cell carcinomas
Authors: Mérot Y , Faucher F , Didierjean L , Saurat JH.
Published: August 2023

Peritumoral lacunas of basal cell carcinoma (BCC) were for a long time misinterpreted as fixation artifacts. However, recent studies showed that they might be considered as a dynamic process related to degenerescence for the palisade cells. We studied three antigens of the epidermal basement membrane zone--type IV collagen, laminin, and bullous pemphigoid antigen--by indirect immunofluorescence in six cases of basal cell carcinoma. We could observe that type IV collagen as well as laminin were expressed as a linear continuous staining pattern surrounding each of the BCC buds. When there was a peritumoral lacuna, only the stroma side of the lacuna was stained. Bullous pemphigoid antigen showed either a linear continuous or discontinuous staining pattern along the basement membrane zone of the carcinomatous buds. At the site of a peritumoral lacuna bullous pemphigoid antigen abruptly disappeared. The loss of bullous pemphigoid antigen might be related to the lacuna formation.
Effects of topically applied clobetasol-17-propionate on histamine release in human skin
Authors: Ståhle M , Hägermark O.
Published: August 2023

The effects of topical glucocorticoid treatment on histamine responses and histamine release induced by the histamine liberating agent compound 48/80 were studied in 17 healthy volunteers. The potent glucocorticoid ointment clobetasol-17-propionate was applied on one upper arm of each individual 14, 4 and 2 hours before testing. The other arm was treated in the same way with the corresponding vehicle. Solutions of histamine and compound 48/80 were injected intradermally in both arms. The size of the flare reaction and the duration of the itch response were recorded. It was found that the flare reactions evoked by histamine were slightly (p less than 0.05) reduced on the steroid-pretreated arm whereas the responses to compound 48/80 were much more suppressed (p less than 0.01). Glucocorticoid treatment did not influence the itch responses to histamine while the itch duration following injection of compound 48/80 was significantly reduced in steroid-treated skin compared to control skin. Our results indicate that topical glucocorticoid treatment can suppress histamine release from dermal mast cells in man.
Serum IgE levels in patients with bullous pemphigoid and its correlation to the activity of the disease and anti-basement membrane zone antibodies
Authors: Asbrink E , Hovmark A.
Published: August 2023

The serum levels of IgE were found to be increased in 24 of 34 patients with an acute exacerbation of bullous pemphigoid. There was no statistically significant correlation between the serum IgE level or the serum anti-basement membrane zone antibody titer and the extent of the disease during an exacerbation. There was however a positive correlation between anti-basement membrane zone antibody titers and serum IgE levels. All but 2 patients showed a normalisation or decline in serum IgE 2-4 months after an exacerbation of the disease. There was also a tendency to declining antibasement membrane zone antibody titers in many patients but changes of these titers could usually not be measured as early as alterations of serum IgE levels were found. Thus in most patients serum IgE was found to be a better laboratory parameter than indirect immunofluorescence for following the activity of the disease.
Contact allergy to 2-hydroxypropyl methacrylate (2-HPMA) in an ultraviolet curable ink
Authors: Björkner B.
Published: August 2023

A patient working in an ink laboratory developed dermatitis on his hands. Patch testing revealed contact allergy to the ink used and to 2-hydroxypropyl methacrylate (2-HPMA), the monomer present in the ink. Guinea pig maximisation test (GPM-test) shows that 2-HPMA is a weak sensitizer. The data suggest cross-reactivity to 2-hydroxyethyl methacrylate (2-HEMA) but not to 2-hydroxypropyl acrylate (2-HPA) or 2-hydroxyethyl acrylate (2-HEA).
Abnormal amino acid composition of nails in Bazex´s paraneoplastic acrokeratosis
Authors: Juhlin L , Baran R.
Published: August 2023

Bazex´s paraneoplastic acrokeratosis is a syndrome with psoriasiform acral hyperkeratosis and nail changes associated with carcinoma of the upper respiratory or alimentary tract. We report here a case where amino acid analysis of the hyperkeratotic and friable nails differed from normal and other diseased nails investigated by us, but they were similar to those reported in trichothiodystrophy or the BIDS syndrome.
Langerhans´ cell and vitiligo: quantitative study of T6 and HLA-DR antigen-expressing cells
Authors: Claudy AL , Rouchouse B.
Published: August 2023

Epidermal Langerhans´ cell (LC) densities in vitiliginous skin (VS) and normal-appearing skin (NAS) were studied in 10 patients with common vitiligo. Monoclonal mouse anti human T6 antigen IgG1 and Ia antigen IgG2 (Ortho Pharmaceuticals) were used to characterize LC. Epidermal LC densities were calculated by means of an ocular square grid and expressed per 0.1 mm2. The results showed that LC densities of VS was similar to that of NAS (p: not significant). No differences were noted in terms of age, sex, progressing, stable or repigmenting vitiligo. We concluded that involvement of LC in vitiligo, if any, does not probably occur via a degenerating mechanism, or via variations in regional densities.
Variations in cutaneous zinc concentrations after oral administration of zinc gluconate
Authors: Dréno B , Stalder JF , Pecquet C , Boiteau HL , Barrière H.
Published: August 2023

The assessment of zinc levels after oral administration of 100 mg of zinc gluconate was performed over a 72-hour period in 3 sectors: plasma, blister fluid and epidermis. The results show that zinc taken orally reaches the epidermis after 72 h and indicate the existence of an intermediary compartment between plasma and epidermis, represented by blister fluid, in which zinc concentration is 243.9 +/- 32.2 micrograms/l, that is, the ratio blister fluid/plasma = 0.33.
Cholinergic urticaria with anaphylaxis induced by exercise or heating
Authors: Baadsgaard O , Lindskov R.
Published: August 2023

No abstract available.
Psoriasis provoked by beta-blocking agents
Authors: Arntzen N , Kavli G , Volden G.
Published: August 2023

23 patients suffering from psoriasis and being treated with beta-blocking agents were compared to a control group regarding psoriasis activity. Seven out of the 23 were affected by psoriasis after introduction of the beta-blocking drug. The mean age of onset was significantly higher (p less than 0.001) than that of the control group, which supports the provoking effects of beta-blocking agents. Remission occurred in 3 out of 4 patients after medication was stopped.
Topical treatment with sulfur 10 per cent for rosacea
Authors: Blom I , Hornmark AM.
Published: August 2023

In a controlled study, topical treatment with sulfur 10 per cent is shown to be equally effective as orally given tetracycline in the management of rosacea.
Treatment of large condylomata of the penis with the neodymium-YAG-laser
Authors: Bahmer FA , Tang DE , Payeur-Kirsch M.
Published: August 2023

Treatment of large condylomata of the glans penis with a neodymium-YAG-laser is reported. The method offers certain advantages over more conventional means of therapy, but requires expensive equipment, experience and that precautionary measures be taken when the high-power laser is operated.
Lichen planus and the liver
Authors: Rebora A , Rongioletti F.
Published: August 2023

No abstract available.
Human T-cell leukemia virus in cutaneous T-cell lymphoma in Denmark. A possible association of HTLV and aneuploidy
Authors: Lange Wantzin G , Saxinger WC , Woods A , Larsen JK , Thomsen K , Gallo RC.
Published: August 2023

Cutaneous T-cell lymphomas (CTCL) are neoplasias of mature T-cells and comprise Sezary syndrome, mycosis fungoides and some cases of lymphomatoid papulosis. Clinically this group of disorders differ from the more aggressive neoplasias of mature T-cells known as adult T-cell leukemia/lymphoma and T-cell lymphosarcoma leukemia which are associated with human T-cell leukemia virus (HTLV). We have found that of 68 patients from Denmark with CTCL ten were positive for HTLV antibodies and that the neoplastic T-cells from skin specimens in seven of eight HTLV-antibody positive patients studied by DNA flow cytometry exhibit DNA aneuploidy. Either one or two hyperdiploid cell clones were present. Aneuploidy was found in two patients with histologically verified mycosis fungoides, in four patients with histological non-diagnostic mycosis fungoides, and in one patient with lymphomatoid papulosis. The present data indicate that further seroepidemiologic survey studies of cutaneous T-cell lymphomas should include the early histological non-diagnostic stages, especially when aneuploidy is present.
Effect of a new retinoid, arotinoid (Ro 13-6298), on in vitro keratinocyte proliferation and differentiation
Authors: Stadler R , Marcelo CL , Voorhees JJ , Orfanos CE.
Published: August 2023

In preliminary clinical trials, a new retinoid, Arotinoid Ro 13-6298, was found highly effective in hyperproliferation and keratotic disorders. The aim of this investigation was to study the effect of Arotinoid on in vitro neonatal mouse keratinocyte proliferation and differentiation. Five doses of Arotinoid were tested. [3H]-Tdr labeling techniques and autoradiography were used to quantitate proliferation. Differentiation was assessed using one-dimensional polyacrylamide gel electrophoresis and autoradiography of six specific protein fractions extracted from the cells using a series of buffers. Our results indicate that Arotinoid is an extremely potent inhibitor of keratinocyte proliferation. Arotinoid significantly decreases the amount and synthesis of non-covalently and disulfide cross-linked keratins and cell envelopes while increasing the quantity of keratohyalin granule-associated proteins. No qualitative change in keratinocyte proteins was observed.
Assessment of atrophy of human skin caused by corticosteroids using chamber occlusion and suction blister techniques
Authors: Somerma S , Lassus A , Salde L.
Published: August 2023

The effect of five corticosteroid ointments on epidermal thickness was studied using occlusive chamber application. Thinning of the epidermis and telangiectasia were noted 3 weeks after application of betamethasone-17-valerate (BV), budesonide (BD), clobetasol-17-propionate (CP), and fluocinolone acetonide (FA), but not of hydrocortisone (HC). Suction blisters were raised at the treated sites. Epidermal thinning was always associated with reduction in cell number. By combining different methods it seems possible to define more precisely the epidermal effects of various corticosteroid preparation.
Follow-up study on Microsporum canis infections in Stockholm, Sweden
Authors: Emtestam L , Kaaman T.
Published: August 2023

No abstract available.
Skin manifestations of tularemia: a study of 88 cases in northern Finland during 16 years (1967-1983)
Authors: Syrjälä H , Karvonen J , Salminen A.
Published: August 2023

88 tularemia patients with secondary skin manifestations seen in northern Finland during 1967-1983 are described in this paper. Tularemia was ulceroglandular in 57% and pulmonary in 27% of the patients. 68% of the patients were women. The most common secondary skin manifestation was papular or vesicopapular eruption which was seen in 42% of the patients. Erythema nodosum either alone or in combination with some other skin eruption was encountered in 28% and erythema multiforme in 9% of the patients. Erythema nodosum was seen more often in patients with pulmonary tularemia than in other types of the disease (p less than 0.01). The clinical pictures of erythema nodosum and erythema multiforme caused by tularemia greatly resembled those caused by Yersinia. Tularemia should be remembered as one possible triggering factor of erythema nodosum and erythema multiforme.
Dinitrochlorbenzene (DNCB) treatment of viral warts. A 5-year follow-up study
Authors: Johansson E , Förström L.
Published: August 2023

A series of 43 patients with therapy-resistant viral warts of long-duration were treated with dinitrochlorbenzene (DNCB). Of the 37 patients, who completed the treatment, 19 were cured, including five of seven patients with hyperkeratotic tumor-like warts. The majority of the patients showed a depressed cell-mediated immune response. 25 patients were reexamined 5 years later and 8 additional patients answered on inquiry. Six (18%) of these patients had warts. Eight of the 21 primarily tuberculin-negative patients had developed immunity to tuberculin, and none of them had warts. Five of the 6 patients with warts were still tuberculin-negative. The reaction to DNCB had reverted to negative in 17 (68%) out of 25 tested patients and in the majority of the remaining cases a weak reaction only was seen. The study does not tell if the cure is a consequence of the DNCB treatment or a function of time. However, it shows that cure is associated with normalization of the cell-mediated immune response. The DNCB hypersensitivity seemed to disappear with time and late complications were not documented.
Acute febrile neutrophilic dermatosis with genital involvement
Authors: Lindskov R.
Published: August 2023

More than 80 cases of acute febrile neutrophilic dermatosis have been published since Sweet in 1964 described the syndrome. Besides skin eruptions, some patients have mucous membrane lesions involving mouth and lips. This report describes a patient with a pustular eruption consistent with Sweet´s syndrome, who is believed to be the first with involvement of genital mucosa.
Spontaneous regression of generalized molluscum contagiosum turning black
Authors: Ogino A , Ishida H.
Published: August 2023

In this report, the unusual case of an infant with extensive eruptive molluscum contagiosum (MC) scattered over the back and buttocks that became inflammatory with blackening and subsequently healed spontaneously over a short period of time is described. To our knowledge, the blackening of spontaneous regressing MC has not yet been described. The mechanism involved in the phenomenon of spontaneous resolution of the inflammatory MC with blackening is discussed.
The functions of polymorphonuclear leukocytes emigrating into the skin
Authors: Csato M , Dobozy A , Raith L , Simon N.
Published: August 2023

The functions of polymorphonuclear leukocytes (PMNs) emigrating into the skin and of others separated simultaneously from the circulation were determined and compared in healthy individuals. The PMNs emigrating into the skin were separated with a skin chamber technique. The C3 rosette forming capacities of the skin migrating and the circulating PMNs were similar. The chemotactic responsiveness was evaluated using three different chemoattractants: zymosan-activated serum, casein and lymphocyte-derived chemotactic factor. The skin PMNs gave practically no chemotactic response in the Boyden chamber, irrespective of the chemoattractant used. On the other hand, the skin PMNs exhibited higher plastic surface adherence, nitroblue tetrazolium reduction and Candida albicans killing activities. The data indicate that some functional activities of PMNs undergo alteration during in vivo emigration into the skin. The alterations, overall, may be of importance in the physiological protective function of the skin.
Cowden´s disease in three siblings: electron-microscope and immunological studies
Authors: Halevy S , Sandbank M , Pick AI , Feuerman EJ.
Published: August 2023

Cowden´s disease was diagnosed in three siblings (two sisters and a brother) in a Jewish Israeli family of Yemenite origin. The typical mucocutaneous lesions of the disease were present in all three cases. There were hamartomas involving other body systems, including euthyroid multinodular goiter (in all 3 cases), gastrointestinal polyposis (in 2 cases) and hemangioma (in one case). Developmental anomalies were found in all 3 cases. Histological examination of mucocutaneous lesions was in accordance with previous descriptions, including the findings compatible with trichilemmoma observed in cutaneous facial papules. Extensive electron-microscope studies of these facial lesions yielded no evidence of viral particles. Immunological studies, carried out mainly in two cases, revealed a decrease in complement level in the serum and impairment of T cell function.
Topical minoxidil for extended areate alopecia
Authors: Frentz G.
Published: August 2023

A double-blind cross over study on the effect of 3 months´ treatment with 1% topical minoxidil on 23 individuals with alopecia areata was performed. Thirteen of the patients showed some increase in terminal hair growth, the difference between the number of responders to placebo and minoxidil lotion being significant (p less than 0.005). However, in one case only, the result was cosmetically satisfying. In two male patients the blood pressure increased coinciding with the withdrawal of the minoxidil lotion.
Acute febrile neutrophilic dermatosis and abnormal bone marrow chromosomes as a marker for preleukemia
Authors: Tikjøb G , Kassis V , Thomsen HK , Jensen G.
Published: August 2023

Acute febrile neutrophilic dermatosis or Sweet´s syndrome is a rare disease, which occasionally is seen in patients with myeloid leukemia. We present a case of Sweet´s syndrome in a patient with an abnormal chromosome pattern in bone marrow aspirate. Initially the patient had flu-like symptoms with high fever. Two weeks later raised, erythematous and painful plaques appeared on the skin. Various antibiotics were ineffective, but the symptoms vanished after administration of prednisone. Six months later a fulminant acute myeloid leukemia developed, the course of which was complicated by a fatal subdural bleeding. It is concluded that Sweet´s syndrome may be a cutaneous sign of a neoplastic myeloid proliferation and that a complete hematological examination including chromosome analysis is mandatory in these patients.
Systemic polychemotherapy in patients with mycosis fungoides and lymph node involvement: a follow-up study of 17 patients
Authors: Sentis HJ , Willemze R , Van Vloten WA.
Published: August 2023

Seventeen patients with mycosis fungoides and lymph node involvement were treated with polycytostatic courses consisting of cyclophosphamide, vincristin (Oncovin) and prednisone (COP). A response rate of 76% was found. In 7 patients (41%) a complete remission and in 6 patients (35%) a partial remission was obtained. The actuarial survival rate at 5 years was 64%. This treatment was well-tolerated by most patients and severe side effects were not observed.
A monoclonal antibody labelling the keratinocyte membrane: a marker of epidermal differentiation
Authors: Viac J , Haftek M , Staquet MJ , Reano A , Brochier J , Thivolet J.
Published: August 2023

A murine hybridoma secreting an IgM monoclonal antibody (KL3) was produced by cell fusion of mouse myeloma cells with spleen cells from mice immunized with human epidermal keratins. On normal human epidermis KL3 stained the intercellular spaces from the stratum germinatum to the stratum granulosum with a fluorescence intensity increasing from the basal layer to the upper layers. Basal cells were not stained on the side facing the basement membrane. About 90% of free keratinocytes isolated after trypsinization were labelled by KL3 in a punctate staining. Immunoelectron microscopy allowed us to show that the antigen recognized by KL3 was exclusively localized on the keratinocyte membrane especially in the desmosomal plaques. KL3 reactivity was not modified by preincubation of skin sections with lectins showing a selective intercellular labelling of upper layers of epidermis or pemphigus antisera, nor by adsorption of the antibody on NP40 soluble proteins of the epidermis. Though KL3 reactivity was completely abolished after adsorption of purified keratins, no immunological reactivity of KL3 was detected with epidermal keratin polypeptides blotted on nitrocellulose paper. In psoriatic epidemis and epidermal tumors KL3 reactivity was drastically modified. These results suggest that KL3 recognized a keratinocyte membrane antigen implied in the epidermal differentiation process.
Human T-lymphotropic retrovirus type III (HTLV-III) in Danish homosexuals
Authors: Lange Wantzin G , Saxinger WC , Weismann K , Gallo RC.
Published: August 2023

Sera from 119 patients attending a venereal disease clinic in Copenhagen during May 1983 were screened for antibodies to the newly characterized and isolated retrovirus HTLV-III. Ten out of 45 (22%) homosexual patients and two out of 74 (2.7%) heterosexual patients were found to have antibodies against HTLV-III. The homosexual group (except one case that developed AIDS and died during one year observation period) contained otherwise healthy men some of which had no contact with individuals from high-risk areas and only a few sexual partners. These results strongly suggest that Danish homosexuals with only few contacts are also at risk and that sero-epidemiological studies should also include the healthy homosexual group and probably the heterosexual group attending venereal disease clinics.
Familial rolled and spiral hairs with palmoplantar keratoderma
Authors: Ortonne JP , Juhlin L , El Baze P , Pautrat G.
Published: August 2023

A 59-year-old man with palmoplantar keratoderma and rolled spiral hairs on the abdomen and extremities is reported. His father had the same skin manifestations but his brother and sister only keratoderma palmoplantare. Scanning electron microscopy of the rolled hairs showed that they were coiled in a spiral around their own axis. These spiral hairs had lower cysteine than the normal appearing hairs on the body. The scalp hair appeared normal but was low in cysteine which was compensated by an increase in threonine. Urine analysis showed a decrease of cysteine.
Cutaneous nasociliary neuralgia
Authors: Lambert WC , Okorodudu AO , Schwartz RA.
Published: August 2023

Nasociliary neuralgia has not to our knowledge been linked with inflammatory cutaneous lesions. We observed the phenomenon and postulate that it may be frequent but overlooked.
Treatment of alopecia areata with diphenylcyclopropenone
Authors: Kietzmann H , Hardung H.
Published: August 2023

No abstract available.
Polymorphic eruption of pregnancy: histopathologic study
Authors: Moreno A , Noguera J , De Moragas JM.
Published: August 2023

The microscopic findings in 31 biopsies of patients with polymorphic eruption of pregnancy are reported with a literature review. Cutaneous changes include edema, dermal lympho-histiocytic infiltrate and epidermal lesions. We have found a correlation between the intensity of the inflammatory response and the presence of epidermal involvement. In our opinion, the histopathological changes may allow an accurate diagnosis with the adequate clinical information. Direct immunofluorescence did not reveal immunoglobulin or complement deposits in the ten cases studied. It may help in the differential diagnosis with nonbullous herpes gestationis.
Differential hepatotoxicity of two oral retinoids (etretinate and isotretinoin) in a patient with palmoplantar psoriasis
Authors: Vahlquist A , Lööf L , Nordlinder H , Rollman O , Vahlquist C.
Published: August 2023

A 64-year-old woman developed biopsy-proven hepatitis during oral treatment of severe pustular psoriasis of palms and soles with an aromatic retinoid, etretinate. The elevations in hepatic enzyme levels reappeared when etretinate was reinstituted 18 months later. Analysis of serum and subcutis showed normal therapeutic concentrations of the drug. Isotretinoin therapy, although apparently devoid of hepatotoxicity, was clinically only marginally effective. Evidence compiled from the literature suggests that etretinate-hepatitis is a drug-specific reaction.
Enzyme production of propionibacteria from patients with acne vulgaris and healthy persons
Authors: Höffler U , Gehse M , Gloor M , Pulverer G.
Published: August 2023

375 strains of propionibacteria isolated from pustules, comedones, and from normal skin of patients with acne vulgaris and from healthy persons have been examined for their enzymatic activity. In contrast to healthy individuals, protease and caseinase production of strains from acne patients was significantly lower. On the other hand, DNA´ase production of strains from acne lesions was increased, and lecithinase could be demonstrated in strains from acne patients only.
Unilateral facial circumscribed hyperhidrosis
Authors: Fernández G , Armijo M.
Published: August 2023

A case of a 15-year-old male with unilateral facial circumscribed hyperhidrosis is reported. No morphological anomalies of the eccrine sweat glands could be noted. The results obtained with local applications of aluminium hexachloride in 20% alcoholic solution are discussed together with the few previous cases appearing in the literature.
Treatment of chancroid with enoxacin
Authors: Mensing H.
Published: August 2023

Chancroid (ulcus molle) was treated in 7 male patients with enoxacin (2 X 400 mg/die). Microbiological and clinical examinations proved complete healing in all cases after 7 to 12 days. No side effects were mentioned. Enoxacin seems to be an excellent alternative treatment for this sexually transmitted disease.
Inflammatory cell types in normal human epidermis--an immunohistochemical and morphometric study
Authors: Smolle J , Ehall R , Kerl H.
Published: August 2023

Inflammatory cells in 15 specimens of normal human epidermis were selectively stained by a monoclonal antibody immunoperoxidase technique. The quantitative assessment using an interactive image analysis system revealed OKT 11 positive cells (T lymphocytes) and Leu 2a positive cells (suppressor/cytotoxic cells). As there was no significant difference in the distribution of these markers, helper/inducer cells obviously are not present in considerable amounts. OKM 5 positive cells outnumbered OKM 1 positive cells, indicating the presence of a OKM 5+, OKM 1-macrophage subset. The epidermal dendritic cells clearly showed a striking heterogeneity regarding the expression of HLA-DR (62% of OKT 6-positive cells) and Leu 3a (47%), suggesting the existence of immunologically distinct subsets of human epidermal dendritic cells.