bluuebunny/crossref_metadata_2025 huggingface dataset:
Cortico‐cortical paired associative stimulation conditioning superficial ventral premotor cortex–primary motor cortex connectivity influences motor cortical activity during precision grip
Authors: Casarotto Andrea , Dolfini Elisa , Fadiga Luciano , Koch Giacomo , D'Ausilio Alessandro
Published: August 2023

The ventral premotor cortex (PMv) and primary motor cortex (M1) represent critical nodes of a parietofrontal network involved in grasping actions, such as power and precision grip. Here, we investigated how the functional PMv–M1 connectivity drives the dissociation between these two actions. We applied a PMv–M1 cortico‐cortical paired associative stimulation (cc‐PAS) protocol, stimulating M1 in both postero‐anterior (PA) and antero‐posterior (AP) directions, in order to induce long‐term changes in the activity of different neuronal populations within M1. We evaluated the motor‐evoked potential (MEP) amplitude, MEP latency and cortical silent period, in both PA and AP, during the isometric execution of precision and power grip, before and after the PMv–M1 cc‐PAS. The repeated activation of the PMv–M1 cortico‐cortical network with PA orientation over M1 did not change MEP amplitude or cortical silent period duration during both actions. In contrast, the PMv–M1 cc‐PAS stimulation of M1 with an AP direction led to a specific modulation of precision grip motor drive. In particular, MEPs tested with AP stimulation showed a selective increase of corticospinal excitability during precision grip. These findings suggest that the more superficial M1 neuronal populations recruited by the PMv input are involved preferentially in the execution of precision grip actions.

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Key points

Ventral premotor cortex (PMv)–primary motor cortex (M1) cortico‐cortical paired associative stimulation (cc‐PAS) with different coil orientation targets dissociable neural populations.

PMv–M1 cc‐PAS with M1 antero‐posterior coil orientation specifically modulates corticospinal excitability during precision grip.

Superficial M1 populations are involved preferentially in the execution of precision grip.

A plasticity induction protocol targeting the specific PMv–M1 subpopulation might have important translational value for the rehabilitation of hand function.
Las manos, las máquinas, Clarice Lispecto
Authors: Estupiñán Serrano Mary Luz
Published: August 2023

La relación entre manos e instrumentos permite comprender por qué las mujeres han estado más del lado del cuerpo y los varones del lado de la técnica y la tecnología. La emergencia de cada máquina no ha hecho más que afirmar esta división; así lo podemos constatar con la máquina de escribir que impactó en la división del trabajo intelectual, pues las mujeres fueron limitadas a conducir las máquinas, no a registrar sus propias creaciones. En este ensayo proponemos que estas dos derivas se complejizan en la escritura de Clarice Lispector, en específico en la figura de Macabea, en quien se interrumpe su cauce imaginario y material.
Competencia en los mercados de energía eléctrica y gas natural, ¿quién es la autoridad competente?
Authors: Plata Puyana José Fernando , De Greiff Correa Andrés
Published: August 2023

Con base en la literatura de la Organización para la Cooperación y el Desarrollo Económicos (OCDE) y el análisis de los casos Empresa de Energía de Boyacá S. A. E. S. P. (EBSA), Empresas Públicas de Medellín (EPM9, Electricaribe, Electrohuila y Emgesa-Efigas, los autores profundizan sobre los beneficios de la complementariedad y el problema de inconsistencia que se producen por la coexistencia entre la Superintendencia de Servicios Públicos Domiciliarios y la Superintendencia de Industria y Comercio, como autoridades para la supervisión de las normas de promoción y protección de la competencia. Los autores plantean que la coexistencia actual genera ineficiencias en el funcionamiento del Gobierno, situación que podría superarse si la Ley 142/94 es modificada en el sentido de equiparar las herramientas con las que cuentan ambas autoridades para ejercer sus funciones de derecho administrativo sancionador. Además, para superar el riesgo de inconsistencia, es necesario que ambas autoridades avancen en las alternativas que recomienda la OCDE para mejorar la coordinación interinstitucional, tales como (i) acuerdos de entendimiento para compartir información, (ii) intercambio de funcionarios y (iii) elaboración de reportes conjuntos, entre otros.
Numerical Simulation of Free Surface Water Waves Around Wavy Hydrofoils: Prediction of Hydrodynamic Coefficients Using Machine Learning
Authors: Tavakoli Ali , Roohi Ehsan , Namaghi Mohammad Sanaee
Published: August 2023

This study uses computational methods to investigate the fluid flow characteristics around a wavy NACA 63(4)-021 hydrofoil near the water surface. It introduces notable contributions to the literature on sinusoidal edge hydrofoils by examining the behavior of this specific hydrofoil configuration close to the water surface, a previously unexplored aspect. Furthermore, the study presents a comprehensive review and analysis of various machine learning (ML) techniques applied to computational fluid dynamics (CFD) and experimental data, offering a novel approach in this field. The three-dimensional Reynolds-averaged Navier–Stokes (RANS) equations are solved using an implicit finite volume approach to simulate the turbulent flow around the hydrofoil near the free surface. The realizable k–ε turbulence model accounts for turbulent flow effects at varying submergence depths. Four machine learning models in Python are developed to predict lift and drag coefficients. Evaluation of these models on training and test datasets reveals that xgboost achieves the highest accuracy, with an impressive R2 score of 0.9775 on the test dataset. Therefore, xgboost is recommended as the optimal model for future applications in this context. The study's findings are presented for the wavy hydrofoil at three submergence depths and three angles of attack (AOA). Key results include wave profiles, magnitudes, total pressure contours around the hydrofoil and free surface, and pressure, lift, and drag coefficients. The accuracy of the numerical simulations is validated by comparing the results with available experimental data, demonstrating good agreement between the two.
Evaluation of the Performance of Twin Rotor Vertical Axis Wind Turbines Employing Large Eddy Simulations
Authors: Sree Raj V. , Solanki Rutvik S. , Chalamalla Vamsi K. , Sinha Sawan S.
Published: August 2023

The current strong global consensus on reducing carbon emissions is a motivation to develop more efficient means of harnessing sustainable sources of energy. Accordingly, research efforts toward the development of more efficient wind turbine designs are desirable. With this motivation, we present a set of numerical studies on flows past vertical axis wind turbines (VAWTs). We perform large eddy simulations (LES) of flows past several VAWT configurations. A uniform inflow is set for our simulations. The influence of turbine blades on the flow field is modeled using the actuator line method (ALM). Our focus is on a twin rotor configuration, wherein the rotors are placed close enough, so that the separation between the centers of the two rotors is less than the diameter of the two individual turbines (the overlapping configuration). We demonstrate that such a configuration indeed results in (a) the enhanced power coefficient (ratio of power extracted by the turbine configuration to the power available in the freestream) and (b) better power density (power extracted by a turbine configuration per unit ground area occupied by the VAWT) compared to a single rotor VAWT configuration. Based on our findings, we conclude that the overlapping twin rotor arrangement can prove to be the preferred configuration for large-scale VAWT-based wind farms.
Understanding the Ecological System: Increasing Women’s Sport Participation Within Bowls Canada Boulingrin
Authors: Pappas Adam T. , Kerwin Shannon
Published: August 2023

This case showcases Amber, the CEO of Bowls Canada Boulingrin (Bowls Canada). Amber and her Board of Directors are looking for ways to increase the number of adult women1 who participate in bowls at the competitive level. Through the case narrative and teaching note, students are asked to explore Bowls Canada’s strategic plan to uncover the organization’s goals around equity, diversity, and inclusion, and review data that has been collected related to barriers for women’s participation in competitive Bowls. Analysis of the data is linked to Social Ecological Theory, which will help students think about the most effective ways to synthesize their understanding of barriers into recommendations for Amber and her Board. The need to use data to make decisions around issues related to equity, diversity, and inclusion is increasingly relevant when addressing multiple concepts in the sport management classroom. The case contributes to engaging discussion that will naturally generate valuable interaction among students.
Determinants of Consumers’ Adoption of Mobile Ticketing via Self-Service Technology
Authors: Kim Sanghoon , Park Kwangho , Uhm Jun-Phil , Lee Hyun-Woo
Published: August 2023

The purpose of this study was to examine the determinants of sport consumers’ mobile ticketing adoption by the technology readiness constructs and quality–satisfaction–behavioral intentions framework. A total of 295 participants were included in the analysis. Data analysis was performed using structural equation modeling and PROCESS macro. A content analysis was conducted to provide further insight into the proposed model using open-ended responses. The findings indicate that consumers’ technology readiness alone was not a positive driver of mobile ticketing but suggest a role for technology readiness in promoting mobile ticketing, combined with service quality, satisfaction, and online ticket purchasing. The importance and originality of this study are that it confirms the sport context as a unique and effective vehicle in advancing existing knowledge of consumers’ ticket consumption behavior via self-service technology across various disciplines. Also, the findings can be used to set out recommendations for policy or practice aimed at facilitating and sustaining mobile ticketing consumption.
Mental Rehearsal Improves Passing Skill and Stress Resilience in Rugby Players
Authors: Beaven C. Martyn , Kilduff Liam P. , Cook Christian J.
Published: August 2023

Purpose: Mental rehearsal is commonly employed, with positive visualization proposed to enhance complex skill performance. Additionally, video stimulus has been associated with enhanced kinesthetic sensations and rapid hormone fluctuations that may contribute to enhancing mental rehearsal and the conscious and unconscious emotional state for skill execution. Here, we assessed the impact of a 15-minute mental rehearsal intervention on rugby-specific tasks and the associated hormone profile. Methods: Professional rugby players (N = 10) volunteered for a randomized crossover study. They completed three 15-minute preparatory phases (positive or negative video-guided mental rehearsal or self-directed mental rehearsal alone) prior to an exercise stressor and rugby-specific passing task. Salivary testosterone and cortisol were monitored to assess stress responses. Results: Performance during the rugby passing task was improved following the positive video condition (91% [7.4%]) compared to the negative video (79% [6.0%]; ES: 1.22 ± 0.75) and self-visualization (86% [5.8%]; ES: 0.58 ± 0.75), with a significant correlation observed between passing performance and salivary testosterone (r = .47 ± .34, P = .0087). Positive video imagery prior to an exercise stressor also significantly enhanced physiological stress resilience (r = .39 ± .36, P = .0352). Conclusions: This pilot study demonstrates that mental rehearsal was enhanced by appropriate, context-specific video presentation. We propose that the interaction between sex steroids, the adrenal axis, and subsequent conscious and unconscious behaviors may be relevant to competitive rugby. Specifically, we suggest that relatively elevated free testosterone imparts a degree of stress resilience, which may lead to enhanced expression of competitive behaviors and provide an enhanced state for rugby skill execution.
Peak Running Demands in Elite Women’s Rugby Sevens and Rugby Union Match Play: A Comparative Study
Authors: Couderc Anthony , Lacome Mathieu , Cheradame Jeremy , Carling Christopher , Piscione Julien
Published: August 2023

Purpose: In women’s rugby, players regularly interchange between the rugby sevens (R7) and rugby union (RU) formats. Yet, the game demands and particularly the physical aspects respective to both formats vary and players must be able to respond accordingly. The aim of this study was to compare peak running demands in R7 and RU players. Methods: A total of 51 international women players participated. HSBC World Sevens Series (n = 19) and Six Nations Rugby Union tournament matches (n = 10) were analyzed for a total of 437 individual match observations. Global positioning systems were utilized to measure total (in meters) and high-speed (above 16 km·h−1, in meters) distance and frequency of accelerations (above 2.5 m·s−2, n) during different rolling-average periods (1–7 min) to obtain peak running activity values. Power law modeling was used to obtain slope and intercept. For all variables, peak values and the value at the 90th percentile (P90) were analyzed. Results: No intercept difference (P = .25; −0.12 ± 0.17) was observed between formats for total distance (161 vs 155 m·min−1). In contrast, R7 players reported a higher intercept (P = .01; −0.29 ± 0.17) for high-speed distance (66 vs 51 m·min−1), while the intercept was higher (P = .01; 0.31 ± 0.20) in RU for accelerations performed (6.1 vs 5.4 n·min−1). Regarding P90, higher values (P < .001) were observed in R7 for total and high-speed distance and accelerations. Conclusions: While peak overall intensity was similar, P90 on the high-speed spectrum was higher in R7. Information on the most demanding match-play periods specific to both women’s rugby formats can inform training specificity by tailoring sessions to ensure sufficient exposure to these peak demands and, consequently, aid transitioning between formats.
Low-Intensity Resistance Exercise Based on Myofascial Chains Alters the Lower-Limb Tension and Improves Health Status in Female Individuals With Knee Osteoarthritis
Authors: Lu Yao , Chen Jie , Zhang Xue-lin
Published: August 2023

Background: Low-intensity resistance exercise therapy (LIRET) based on myofascial chains, applied to both affected and nonlocal joints, is an effective method for knee osteoarthritis (OA) rehabilitation. This study applied LIRET in a comparison of prevalues and postvalues of lower-limb tension in female patients with knee OA and asymptomatic participants. Methods: Twenty-four female participants with knee OA and 20 asymptomatic women took part in a 3-month long application of LIRET. Participants’ ankle passive torque and ankle range of motion in the sagittal plane were assessed with an isokinetic dynamometer. The collected values were used to estimate the sagittal-plane lower-limb tension. Results: Compared with the asymptomatic group, participants with knee OA presented decreased maximum ankle dorsiflexion (P < .001), decreased ankle plantar flexion range (P = .023), ankle resting position more inclined to dorsiflexion (P = .017), increased ankle dorsiflexion stiffness (P = .005), and lower ankle plantar flexion stiffness (P = .034). After exercise intervention, the knee OA group self-reported less knee pain (P < .001), improved physical function (P < .001), increased maximum dorsiflexion (P = .021), and increased plantar flexion range (P < .001). While plantar flexion stiffness increased (P = .037), dorsiflexion stiffness decreased (P = .015) and ankle resting position moved toward dorsiflexion (P = .002). Results suggest possible decreased anterior leg tension and possible increased posterior leg tension in patients with knee OA. Conclusions: The results supported that knee OA patients present imbalanced myofascial tension of lower limbs. LIRET based on myofascial chains appears to decrease pain, and stiffness, and improve physical function of patients with knee OA and change their lower-limb tension.
Naked mole-rats slay zombies
Authors: VanHook Annalisa M.
Published: August 2023

Senescent cells in naked mole-rats are eliminated by apoptosis.
Complete genome sequence of
Rhizobium leguminosarum
bv. viciae SRDI969, an acid-tolerant, efficient N
2
-fixing microsymbiont of
Vicia faba
Authors: Kohlmeier MacLean G. , Farquharson Elizabeth A. , Ballard Ross A. , O’Hara Graham W. , Terpolilli Jason J.
Published: August 2023

We report the complete genome sequence of
Rhizobium leguminosarum
bv. viciae SRDI969, an acid-tolerant, efficient nitrogen-fixing microorganism of
Vicia faba
. The 6.8 Mbp genome consists of a chromosome and four plasmids, with the symbiosis and nitrogen fixation genes encoded on the chromosome.
Energy Spectrum of the Valence Band in HgTe Quantum Wells on the Way from a Two- to Three-Dimensional Topological Insulator
Authors: Minkov G. M. , Rut O. E. , Sherstobitov A. A. , Dvoretsky S. A. , Mikhailov N. N. , Aleshkin V. Ya.
Published: August 2023

The magnetic field and temperature dependences of longitudinal magnetoresistance and the Hall effect have been measured in order to determine the energy spectrum of the valence band in HgTe quantum wells with the width dQW = 20–200 nm. The comparison of hole densities determined from the period of Shubnikov–de Haas oscillations and the Hall effect shows that states at the top of the valence band are doubly degenerate in the entire dQW range, and the cyclotron mass $${{m}_{h}}$$ determined from the temperature dependence of the amplitude of Shubnikov–de Haas oscillation increases monotonically from $$0.2{{m}_{0}}$$ to $$0.3{{m}_{0}}$$ ($${{m}_{0}}$$ is the mass of the free electron) with increasing hole density $$p$$ from $$2 \times {{10}^{{11}}}$$ to $$6 \times {{10}^{{11}}}$$ cm–2. The determined dependence has been compared to theoretical dependences $${{m}_{h}}(p,{{d}_{{{\text{QW}}}}})$$ calculated within the four-band kP model. These calculations predict an approximate stepwise increase in $${{m}_{h}}$$ owing to the pairwise merging of side extrema with increasing hole density, which should be observed at $$p = (4{-} 4.5) \times {{10}^{{11}}}$$ and 4 × 1010 cm–2 for dQW = 20 and 200 nm, respectively. The experimental dependences are strongly inconsistent with this prediction. It has been shown that the inclusion of additional factors (electric field in the quantum well, strain) does not remove the contradiction between the experiment and theory. Consequently, it is doubtful that the mentioned kP calculations adequately describe the valence band at all dQW values.
Effect of dexmedetomidine on postoperative nausea and vomiting in patients under general anaesthesia: an updated meta-analysis of randomised controlled trials
Authors: Zhao Weihong , Li Jianli , Wang Na , Wang Zhibin , Zhang Meng , Zhang Huanhuan , Liu Meinv , He Jinhua , Yu Dongdong
Published: August 2023

Objectives

To explore the effect of dexmedetomidine (DEX) on postoperative nausea and vomiting (PONV) in adult patients after general anaesthesia.

Design

Systematic review and meta-analysis.

Eligibility criteria for selecting studies

Randomised controlled trials (RCTs) comparing the efficacy of DEX with placebo or a single drug on PONV in adult patients after general anaesthesia.

Data sources

We searched the PubMed, the Web of Science, the Cochrane Library and Embase (1 January 2000 to 30 June 2022) to select the relevant RCTs.

Data analysis

All the relevant data were analysed by using RevMan V.5.4. Heterogeneity was tested for each outcome, and random-effect or fixed-effect models was selected according to the level of heterogeneity. The primary outcome was the incidence of PONV. The secondary outcomes were the incidence of bradycardia, perioperative opioid consumption, extubation time and the length of hospitalisation.

Results

A total of 18 trials involving 2018 patients were included in this meta-analysis. Notably, 15 updated studies were not involved in the previous meta-analysis. The incidence of PONV in DEX group was lower than that in the control group (OR=0.49, 95% CI: 0.36 to 0.67) and the perioperative opioid consumption in DEX group was also decreased significantly (standard mean difference (SMD)=−1.04, 95% CI: −1.53 to −0.54). Moreover, the length of hospitalisation (SMD=−2.29, 95% CI: −4.31 to −0.28) and the extubation time (SMD=−0.75, 95% CI: −1.26 to −0.25) in DEX group were shorter. Whereas, more number of patients receiving DEX might increase the occurrence of bradycardia (OR=1.60, 95% CI: 1.13 to 2.27).

Conclusions

DEX could decrease the occurrence of PONV in adult patients under general anaesthesia and promote the recovery after surgery. However, DEX might increase the occurrence of bradycardia.

PROSPERO registration number

CRD 42022341548.
Protocol of Tecopox study: a multicentre, open-label, double-arm trial to evaluate the efficacy and safety of oral tecovirimat therapy for patients with smallpox or monkeypox
Authors: Suzuki Tetsuya , Saito Sho , Tsuzuki Shinya , Ashida Shinobu , Takakusaki Mizue , Yoshikawa Tomoki , Shimojima Masayuki , Ebihara Hideki , Ohmagari Norio , Morioka Shinichiro
Published: August 2023

Introduction

Monkeypox was originally endemic locally in West Africa; however, outbreaks in non-endemic countries have been recognised since May 2022. The effectiveness of tecovirimat has been estimated against smallpox, which belongs to the sameOrthopoxvirusgenus as monkeypox. Thus, tecovirimat is expected to be effective against monkeypox. This study aims to evaluate the efficacy and safety of oral tecovirimat therapy for patients with smallpox and monkeypox and to prepare a scheme for oral tecovirimat use in Japan.

Methods and analysis

This nationwide, multicentre, non-randomised, open-label, double-arm study will involve viral examination of the blood, throat swabs, urine and skin lesions, performed periodically. Participants will freely decide whether to participate in an administered group (supportive treatment plus oral tecovirimat) or a non-administered group (only supportive treatment). Tecovirimat will be administered for 14 days. To ensure that financial problems do not preclude participation in the study, the research fund will cover the cost of tecovirimat and basic hospitalisation fees. The primary endpoint is the percentage of patients with negative PCR results (cycle threshold value ≥40) for skin lesion specimens at 14 days after inclusion in the study. Secondary endpoints include mortality at 14 and 30 days, viral load in each sample, duration of fever and adverse events. The sample size is estimated to be 50 patients with monkeypox or smallpox.

Ethics and dissemination

Written informed consent will be obtained from all participants. This study was approved by the Certified Review Board of National Center for Global Health and Medicine and published in the Japan Registry of Clinical Trials. The results of this study will be published in peer-reviewed journals and/or in presentations at academic conferences.

Trial registration number

jRCTs031220169.
Controlling Hypertension through Education and Coaching in Kidney Disease (CHECK-D): protocol of a cluster randomised controlled trial
Authors: Wright Nunes Julie A , Resnicow Ken , Richardson Caroline , Levine Diane , Kerr Eve , Saran Rajiv , Gillespie Brenda , Bragg-Gresham Jennifer , Delacroix Emerson L , Considine Shannon , Fan Audrey , Ellies Tammy , Garcia-Guzman Luis , Grzyb Katie , Klinkman Michael , Rockwell Pamela , Billi John , Martin Carly , Collier Kristin , Parker-Featherstone Ebony , Bryant Nicole , Seitz Maria , Lukela Jennifer , Brinley Floyd John , Fagerlin Angela
Published: August 2023

Introduction

Chronic kidney disease (CKD) affects 30 million Americans. Early management focused on blood pressure (BP) control decreases cardiovascular morbidity and mortality. Less than 40% of patients with CKD achieve recommended BP targets due to many barriers. These barriers include a lack of understanding of the implications of their diagnosis and how to optimise their health.

This cluster randomised control trial hypothesises that the combination of early primary care CKD education, and motivational interviewing (MI)-based health coach support, will improve patient behaviours aligned with BP control by increasing patient knowledge, self-efficacy and motivation. The results will aid in sustainable interventions for future patient-centric education and coaching support to improve quality and outcomes in patients with CKD stages 3–5. Outcomes in patients with CKD stages 3–5 receiving the intervention will be compared with similar patients within a control group. Continuous quality improvement (CQI) and systems methodologies will be used to optimise resource neutrality and leverage existing technology to support implementation and future dissemination. The innovative approach of this research focuses on the importance of a multidisciplinary team, including off-site patient coaching, that can intervene early in the CKD care continuum by supporting patients with education and coaching.

Methods and analysis

We will test impact of BP control when clinician-delivered education is followed by 12 months of MI-based health coaching. We will compare outcomes in 350 patients with CKD stages 3–5 between intervention and control groups in primary care. CQI and systems methodologies will optimise education and coaching for future implementation and dissemination.

Ethics and dissemination

This study was approved by the University of Michigan Institutional Review Boards (IRBMED) HUM00136011, HUM00150672 and SITE00000092 and the results of the study will be published on ClinicalTrials.gov, in peer-reviewed journals, as well as conference abstracts, posters and presentations.

Trial registration number

NCT04087798.
Risk of sexual dysfunctions in breastfeeding females: protocol for a systematic review and meta-analysis
Authors: Smetanina Darya , Awar Shamsa Al , Khair Howaida , Alkaabi Meera , Das Karuna M , Ljubisavljevic Milos , Statsenko Yauhen , Zaręba Kornelia Teresa
Published: August 2023

Background

Epidemiological studies do not provide accurate statistics on the percentage of breastfeeding women experiencing sexual dysfunctions and restraining from sexual activity. The data vary between 40% and 83% in the first group and 20–50% in the second one. Despite excessive studies on contributors to intimacy changes, breast feeding received little attention from researchers. The relationship between lactation and postpartum sexual dysfunctions remains unclear. This systematic review and meta-analysis will synthesise available data and establish the link between breast feeding and sexuality problems.

Methods and analysis

A comprehensive literature search will be performed in biomedical databases PubMed/Medline, Scopus, Web of Science, EMBASE and CINAHL. We will extract peer-reviewed original studies written in English, Arabic or Polish from 2000 to June 2023. We will also search for reports from international health organisations and local health authorities. The preliminary search was performed on 04 April 2023. The studies must provide data on dysfunction prevalence/incidence and the strength of the relationship between breast feeding and sexuality in generally healthy women. The Covidence software will be used to perform literature screening, data extraction and quality assessment of individual studies. We will use a random-effects model meta-analysis to calculate pooled weighted frequency measures and effect size. Between-study heterogeneity will be assessed with the I2test.

Ethics and dissemination

This meta-analysis does not require ethical approval because it synthesises data from previously published original studies. The final work will be published in a peer-reviewed journal and presented at scientific conferences.

PROSPERO registration number

CRD42023411053.
Bedtime versus morning use of antihypertensives in frail continuing care residents (BedMed-Frail): protocol for a prospective, randomised, open-label, blinded end-point pragmatic trial
Authors: Garrison Scott R , Youngson Erik , Perry Danielle A , Campbell Farah N , Kolber Michael R , Korownyk Christina , Allan Gary Michael , Green Lee , Bakal Jeffrey
Published: August 2023

Introduction

BedMed-Frail explores risks and benefits of switching antihypertensives from morning to bedtime in a frail population at greater risk of hypotensive adverse effects.

Methods and analysis

Design: Prospective parallel randomised, open-label, blinded end-point trial.

Participants: Hypertensive continuing care residents, in either long-term care or supportive living, who are free from glaucoma, and using ≥1 once daily antihypertensive.

Setting: 16 volunteer continuing care facilities in Alberta, Canada, with eligible residents identified using electronic health claims data.

Intervention: All non-opted out eligible residents are randomised centrally by the provincial health data steward to bedtime versus usual care (typically morning) administration of once daily antihypertensives. Timing changes are made (maximum one change per week) by usual care facility pharmacists.

Follow-up: Via linked governmental healthcare databases tracking hospital, continuing care and community medical services.

Primary outcome: Composite of all-cause death, or hospitalisation for myocardial infarction/acute-coronary syndrome, stroke, or congestive heart failure.

Secondary outcomes: Each primary outcome element on its own, all-cause unplanned hospitalisation or emergency department visit, non-vertebral fracture and, as assessed roughly 135 days postrandomisation, fall in the last 30 days, deteriorated cognition, urinary incontinence, decubitus skin ulceration, inappropriate or disruptive behaviour a minimum of 4 days per week, and receipt of antipsychotic medication or physical restraints in the last 7 days.

Process outcome: Proportion of blood pressure medication doses taken at bedtime (broken down monthly).

Primary outcome analysis: Cox-Proportional Hazards Survival Analysis.

Sample size: The trial will continue until a projected 368 primary outcome events have occurred.

Current status: Enrolment is ongoing with 642 randomisations to date (75% female, mean age 88 years).

Ethics and dissemination

BedMed-Frail has ethical approval from the University of Alberta Health Ethics Review Board (Pro00086129) and will publish results in a peer-reviewed journal.

Trial registration number

NCT04054648.
A Guide to Hunting Long-Lived Particles at the LHC
Authors: Knapen Simon , Lowette Steven
Published: August 2023

This article is a pedagogical review of searches for long-lived particles at the LHC. It is primarily aimed at experimentalists and theorists seeking to initiate and/or deepen their research in this field. We cover the general theoretical motivation and some example models, the main experimental techniques employed in searches for long-lived particles, and some of the important subtleties involved in estimating signal efficiencies and background rates.
Enhancing Sensitivity of Manganese Detection in Drinking Water Using Nanomaterial AuNPs/GP
Authors: Macdonald Kirsten , Pei Yu , Omoboye Adekunle , Lamothe Nicholas , Shi Yichun , McEleney Kevin , Payne Sarah Jane , She Zhe
Published: August 2023

Manganese (Mn) was previously considered a mere aesthetic concern that causes colored water and stained surfaces; however, recent epidemiological research found that excessive exposure to Mn has neurotoxic effects on humans, especially in children. In response to the health concerns, Health Canada and the World Health Organization moved towards stricter standards on Mn to protect public health. Currently, the standard analytical methods for Mn2+ are spectroscopic. Although they are highly sensitive, they are not cost effective or portable for high frequency analysis in the field. In this article, the sensitivity of electrochemical techniques, chronoamperometry (CA) and cathodic stripping voltammetry (CSV), are compared as well as the sensitivity of a non-modified glassy carbon screen-printed electrode (GCE SPE) vs a gold nanoparticle modified graphene (AuNPs/GP) coated GCE SPE for Mn2+ detection and quantification. Regarding the coating of the GCE SPE, detection performed with AuNPs/GP modified GCE SPE shows a wider linear range from 0–520 μM and an improved LOD of 0.75 μM. Application of the sensors was tested using drinking water samples returning high recovery rates from 92.9 to 106.8% depending on material and method used for Mn2+ detection and quantification.
Conservative Treatment of Bilateral Impacted Mandibular Canines Traction
Authors: Ruíz-Mora Gustavo Armando , Arriola-Guillén Luis Ernesto , Aliaga-Del Castillo Aron , Rodríguez-Cárdenas Yalil Augusto , Dutra Vinicius , Mejía-Milian Mabel
Published: August 2023

The objectives of the treatment of impacted canines differ according to the characteristics of dental malocclusion. Traction of the tooth is a conservative and viable alternative, which allows for maintaining stability and occlusal function. The following case report describes the treatment of an 11.6-year-old female patient, who presented bilateral impaction of mandibular canines in contact with the midline, mixed dentition in the inter-transitional period, class I angle malocclusion, with light crowding teeth. The treatment comprised three phases. The first phase, verticalization of the mandibular canines in mixed dentition, was performed to pull the impacted bilateral mandibular canines towards the dental arch to achieve their verticalization, maintaining the molar relationship, and the position of the upper and lower incisors. In the second phase, osteogenic rest was planned to relieve post-traction stress while awaiting the replacement of the mixed dentition. Finally, the third phase in permanent dentition was to align and level canines within the arch after extraction of the deciduous canines. For the viability of the permanent mandibular canines in the dental arch, orthosurgical traction was implemented, with a traction system with closed nickel–titanium coil springs with a transitory rigid dental-mucous-supported anchorage device, which allowed control and protection of the adjacent teeth and movements with helical forces of a controlled three-dimensional range. The results of the treatment were adequate, achieving consolidated molar and canine relationships, overjet, overbite, and optimal facial balance.
Table S6 from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Suppl. Table S6, Copy number from whole exome sequencing
Table S5 from Characterizing Evolutionary Dynamics Reveals Strategies to Exhaust the Spectrum of Subclonal Resistance in EGFR-Mutant Lung Cancer
Authors: Müller Nina , Lorenz Carina , Ostendorp Jenny , Heisel Felix S. , Friese Ulrich P. , Cartolano Maria , Plenker Dennis , Tumbrink Hannah , Heimsoeth Alena , Baedeker Philipp , Weiss Jonathan , Ortiz-Cuaran Sandra , Büttner Reinhard , Peifer Martin , Thomas Roman K. , Sos Martin L. , Berg Johannes , Brägelmann Johannes
Published: August 2023

Table S5 mutations from Whole exome sequencing
Table S2 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Table S2
Figure S9 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 9
Figure S7 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 7
Figure S6 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 6
Figure S3 from Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Authors: Kanholm Tomas , Rentia Uzma , Hadley Melissa , Karlow Jennifer A. , Cox Olivia L. , Diab Noor , Bendall Matthew L. , Dawson Tyson , McDonald James I. , Xie Wenbing , Crandall Keith A. , Burns Kathleen H. , Baylin Stephen B. , Easwaran Hari , Chiappinelli Katherine B.
Published: August 2023

Supplemental Figure 3
Table 1 from A Genetic Locus within the FMN1/GREM1 Gene Region Interacts with Body Mass Index in Colorectal Cancer Risk
Authors: Aglago Elom K. , Kim Andre , Lin Yi , Qu Conghui , Evangelou Marina , Ren Yu , Morrison John , Albanes Demetrius , Arndt Volker , Barry Elizabeth L. , Baurley James W. , Berndt Sonja I. , Bien Stephanie A. , Bishop D. Timothy , Bouras Emmanouil , Brenner Hermann , Buchanan Daniel D. , Budiarto Arif , Carreras-Torres Robert , Casey Graham , Cenggoro Tjeng Wawan , Chan Andrew T. , Chang-Claude Jenny , Chen Xuechen , Conti David V. , Devall Matthew , Diez-Obrero Virginia , Dimou Niki , Drew David , Figueiredo Jane C. , Gallinger Steven , Giles Graham G. , Gruber Stephen B. , Gsur Andrea , Gunter Marc J. , Hampel Heather , Harlid Sophia , Hidaka Akihisa , Harrison Tabitha A. , Hoffmeister Michael , Huyghe Jeroen R. , Jenkins Mark A. , Jordahl Kristina , Joshi Amit D. , Kawaguchi Eric S. , Keku Temitope O. , Kundaje Anshul , Larsson Susanna C. , Marchand Loic Le , Lewinger Juan Pablo , Li Li , Lynch Brigid M. , Mahesworo Bharuno , Mandic Marko , Obón-Santacana Mireia , Moreno Victor , Murphy Neil , Nan Hongmei , Nassir Rami , Newcomb Polly A. , Ogino Shuji , Ose Jennifer , Pai Rish K. , Palmer Julie R. , Papadimitriou Nikos , Pardamean Bens , Peoples Anita R. , Platz Elizabeth A. , Potter John D. , Prentice Ross L. , Rennert Gad , Ruiz-Narvaez Edward , Sakoda Lori C. , Scacheri Peter C. , Schmit Stephanie L. , Schoen Robert E. , Shcherbina Anna , Slattery Martha L. , Stern Mariana C. , Su Yu-Ru , Tangen Catherine M. , Thibodeau Stephen N. , Thomas Duncan C. , Tian Yu , Ulrich Cornelia M. , van Duijnhoven Franzel JB , Van Guelpen Bethany , Visvanathan Kala , Vodicka Pavel , Wang Jun , White Emily , Wolk Alicja , Woods Michael O. , Wu Anna H. , Zemlianskaia Natalia , Hsu Li , Gauderman W. James , Peters Ulrike , Tsilidis Konstantinos K. , Campbell Peter T.
Published: August 2023

Selected characteristics of the participants.
Supplementary File 2 from Proteasome Inhibition Sensitizes Liposarcoma to MDM2 Inhibition with Nutlin-3 by Activating the ATF4/CHOP Stress Response Pathway
Authors: Ludwig Michael P. , Galbraith Matthew D. , Eduthan Neetha Paul , Hill Amanda A. , Clay Michael R. , Tellez Cristiam Moreno , Wilky Breelyn A. , Elias Anthony , Espinosa Joaquin M. , Sullivan Kelly D.
Published: August 2023

Nutlin-3-treated LPS transcriptome analyses.
Supplementary Data from Profiling the Somatic Mutational Landscape of Breast Tumors from Hispanic/Latina Women Reveals Conserved and Unique Characteristics
Authors: Ding Yuan Chun , Song Hanbing , Adamson Aaron W. , Schmolze Daniel , Hu Donglei , Huntsman Scott , Steele Linda , Patrick Carmina S. , Tao Shu , Hernandez Natalie , Adams Charleen D. , Fejerman Laura , Gardner Kevin , Nápoles Anna María , Pérez-Stable Eliseo J. , Weitzel Jeffrey N. , Bengtsson Henrik , Huang Franklin W. , Neuhausen Susan L. , Ziv Elad
Published: August 2023

Tables S1-S9
Supplementary Table S7 from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

List of the CGIs that overlap between the TCGA dataset of lung squamous cell carcinoma (LUSC) and RYBP/T123 QKO cells
Supplementary Table S5 from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

DMRs
Supplementary Table S2 from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

List of HBEC3 clonal KO cell lines. Mutated DNA sequences are indicated.
Supplementary Figures from Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation
Authors: Cui Wei , Huang Zhijun , Jin Seung-Gi , Johnson Jennifer , Lau Kin H. , Hostetter Galen , Pfeifer Gerd P.
Published: August 2023

Supplementary Figures S1 to S11
Supplementary Figure Legends from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure Legends
Supplementary Figure 2 from PTEN Loss Confers Resistance to Anti–PD-1 Therapy in Non–Small Cell Lung Cancer by Increasing Tumor Infiltration of Regulatory T Cells
Authors: Exposito Francisco , Redrado Miriam , Houry Maeva , Hastings Katherine , Molero-Abraham Magdalena , Lozano Teresa , Solorzano Jose Luis , Sanz-Ortega Julian , Adradas Vera , Amat Ramon , Redin Esther , Leon Sergio , Legarra Naroa , Garcia Javier , Serrano Diego , Valencia Karmele , Robles-Oteiza Camila , Foggetti Giorgia , Otegui Nerea , Felip Enriqueta , Lasarte Juan J. , Paz-Ares Luis , Zugazagoitia Jon , Politi Katerina , Montuenga Luis , Calvo Alfonso
Published: August 2023

Supplementary Figure 2
Table S1-S9 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

All supplementary tables in one excel file
Supplementary Data from The mTOR Signaling Pathway Interacts with the ER Stress Response and the Unfolded Protein Response in Cancer
Authors: Mafi Sahar , Ahmadi Elham , Meehan Eileen , Chiari Conner , Mansoori Behzad , Sadeghi Hossein , Milani Sahar , Jafarinia Morteza , Taeb Shahram , Mafakheri Bashmagh Bayan , Mansoorian Seyed Mohammad Ali , Soltani-Zangbar Mohammad Sadegh , Wang Kepeng , Rostamzadeh Davoud
Published: August 2023

Supplementary Fig. S2
Supplementary Data from The mTOR Signaling Pathway Interacts with the ER Stress Response and the Unfolded Protein Response in Cancer
Authors: Mafi Sahar , Ahmadi Elham , Meehan Eileen , Chiari Conner , Mansoori Behzad , Sadeghi Hossein , Milani Sahar , Jafarinia Morteza , Taeb Shahram , Mafakheri Bashmagh Bayan , Mansoorian Seyed Mohammad Ali , Soltani-Zangbar Mohammad Sadegh , Wang Kepeng , Rostamzadeh Davoud
Published: August 2023

Supplementary Fig. S1
Figure S3 from BRCA1 Insufficiency Induces a Hypersialylated Acidic Tumor Microenvironment That Promotes Metastasis and Immunotherapy Resistance
Authors: Shu Xiaodong , Li Jianjie , Chan Un In , Su Sek Man , Shi Changxiang , Zhang Xin , An Tingting , Xu Jun , Mo Lihua , Liu Jianlin , Wang Yuqing , Li Xiaoling , Deng Min , Lei Josh Haipeng , Wang Chunfei , Tian Hao , Heng Sun , Shim Joong Sup , Zhang Xuanjun , Dai Yunlu , Yao Zhicheng , Kuang Xiaying , Lin Ying , Deng Chu-Xia , Xu Xiaoling
Published: August 2023

Original picture
Supplementary Data from Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J.
Published: August 2023

Supplementary Movie 2
Supplementary Data from Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J.
Published: August 2023

Supplementary Movie 4
Supplementary Data from Plasma Membrane Channel TRPM4 Mediates Immunogenic Therapy–Induced Necrosis
Authors: Ghosh Santanu , Yang Rachel , Duraki Darjan , Zhu Junyao , Kim Ji Eun , Jabeen Musarrat , Mao Chengjian , Dai Xinyi , Livezey Mara R. , Boudreau Matthew W. , Park Ben H. , Nelson Erik R. , Hergenrother Paul J. , Shapiro David J.
Published: August 2023

Title corrected
Clinical trial protocol1 from Combination ATR (ceralasertib) and PARP (olaparib) Inhibitor (CAPRI) Trial in Acquired PARP Inhibitor–Resistant Homologous Recombination–Deficient Ovarian Cancer
Authors: Wethington Stephanie L. , Shah Payal D. , Martin Lainie , Tanyi Janos L. , Latif Nawar , Morgan Mark , Torigian Drew A. , Rodriguez Diego , Smith Simon A. , Dean Emma , Domchek Susan M. , Drapkin Ronny , Shih Ie-Ming , Brown Eric J. , Hwang Wei-Ting , Armstrong Deborah K. , Gaillard Stephanie , Giuntoli Robert , Simpkins Fiona
Published: August 2023

Trial protocol
Supplementary Table S2 from Genomic Profiling of Radiation-Induced Sarcomas Reveals the Immunologic Characteristics and Its Response to Immune Checkpoint Blockade
Authors: Hong Dong-Chun , Yang Jing , Sun Cong , Liu Yuan-Tao , Shen Lu-Jun , Xu Bu-Shu , Que Yi , Xia Xiaojun , Zhang Xing
Published: August 2023

Differentially expressed genes (DEG), possible fusion genes and alternative splicing events, and the anti-tumor immunity scores and proliferation module scores of each sample.