bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR – FAKTOR YANG MEMPENGARUHI RISIKO INVESTASI SAHAM (Studi Empiris Pada Perusahaan Manufaktur Yang Terdaftar Di Bursa Efek Indonesia)
Authors: Lailatullatifa  , MOCHAMMAD SHULTHONI
Published: March 2024

The purpose of this study is to investigate and examine the factors that mempangaruhi risk investments in companies listed in Indonesia Stock Exchange is an interesting thing to do because of the nature of the risks that are always inherent in any investment, especially investment in common stock. This study uses secondary data collection techniques, to conduct library research and documentation. Secondary data were those used in this study were obtained from the official website of the Indonesia Stock Exchange and Bank Indonesia official website Companies sampled in this study amounted to 71-year study period from 2010 to 2012, the sampling technique used was purposive sampling. The data used are the financial statements and the Indonesian Capital Market Directory (ICMD). Data analysis techniques in this study using multiple regression, hypothesis testing method used is the coefficient of determination, simultaneous regression coefficient test, and test the partial regression coefficients, using the F-test and t-test at the 5% level of significance (α = 0.05 ). T test showed that capital structure has significant value equal to 0.05, financial leverage has a significant value below 0.05 is equal to 0.000, while the company's liquidity has a value of 0.019, meaning that the structure of capital, financial leverage, and liquidity of the company has significant influence against the risk of stock investing. While variable rate of inflation does not significantly above the value of 0.05 is 0.752. F test results indicate that the structure of capital, financial leverage, firm liquidity, and inflation effect on the risk of investment sim.
ANALISIS PENGARUH SERVQUAL, KEPERCAYAAN, KEPUASAN, KOMITMEN TERHADAP CUSTOMER LOYALTY (Study Kasus pada PT. Bank Tabungan Negara Madiun)
Authors: Muhammad Supriyanto
Published: March 2024

Tujuan penelitian ini  antara lain adalah Untuk mengetahui pengaruh Servqual, Kepercayaan (Trust), Kepuasan (Satisfaction), dan Komitmen (Commitment) secara parsial terhadap  customer loyalty Bank Tabungan Negara Madiun serta Untuk mengetahui pengaruh Servqual, Kepercayaan (Trust), Kepuasan (Satisfaction), dan Komitmen (Commitment) secara simultan terhadap  customer loyalty Bank Tabungan Negara Madiun.

Populasi penelitian ini adalah nasabah PT. Bank Tabungan Negara Cabang Madiun dengan jumlah responden sebanyak 200 nasabah.

Hasil penelitian : Pertama : variabel servqual berpengaruh secara signifikan atau positif terhadap customer loyalty. Penelitian ini penelitian terdahulu yang menyatakan bahwa variabel kualitas pelayanan terbukti berpengaruh signifikan terhadap loyalitas pelanggan . Kedua penelitian ini menunjukkan bahwa kepercayaan (trust)  tidak berpengaruh secara tidak signifikan terhadap customer loyalty. Penelitian ini tidak mendukung teori Jones dan Sasser (1995) dalam Morganosky dan Cude (2003) menyatakan bahwa hubungan kepuasan dan loyalitas tidak linier. Loyalitas diukur dari maksud/minat yang dinyatakan konsumen dan hasilnya menunjukkan bahwa perpindahan konsumen ke tingkat kepuasan yang lebih tinggi dapat membangun loyalitas jangka panjang. Oleh karena itu kepercayaan konsumen (pasien) dihubungkan secara langsung untuk memenuhi harapan, maka kepuasan sepanjang waktu dapat memperkuat reliabilitas yang dirasakan (perceived reliability) dari RSUD dan memberi kontribusi pada kepercayaan konsumen (pasien) dan masyarakat (Ganesan, 1994 dalam Tax  et al., 1998). Ketiga menunjukkan bahwa variabel kepuasan (satisfaction) berpengaruh secara signifikan terhadap customer loyalty. Penelitian ini mendukung teori Garbarino dan Johnson, (1999) yang menemukan fakta bahwa kepuasan mempunyai pengaruh langsung terhadap kepercayaan dan komitmen, sementara itu kepercayaan merupakan bagian mendasar bagi terbentuknya komitmen  (Hennig-Thurau, 2002). Keempat menunjukkan bahwa variabel komitmen (commitment) berpengaruh secara signifikan terhadap customer loyalty. Penelitian ini mendukung penelitian Pritchard, Havits, dan Howard (1999) yang berhasil mengungkapkan bahwa konsekuensi dari adanya komitmen adalah loyalitas. Kelima penelitian ini menunjukkan bahwa seluruh variabel servqual, kepercayaan (trust), kepuasan (satisfaction), dan komitmen (commitment) secara bersama-sama berpengaruh secara signifikan terhadap customer loyalty  PT Bank Tabungan Negara Cabang Madiun. Penelitian ini mendukung penelitian terdahulu yang dilakukan oleh Ramadania (2002) Napitupulu (2002) Rachmawati (2003) Sudaryoto (2003). Keenam penelitian ini menunjukkan bahwa variabel ketanggapan (responsiveness) merupakan variabel yang paling dominan mempengaruhi kepuasan customer loyalty di PT Bank Tabungan Negara Cabang Madiun.
PENGARUH KEPERILAKUAN ORGANISASI TERHADAP KEGUNAAN SISTEM AKUNTANSI KEUANGAN DAERAH DI PEMERINTAH KOTA KEDIRI JAWA TIMUR
Authors: Novie Astuti Setianingsih
Published: March 2024

The purpose of this study was to test the direct effect of behavioral factors such as the organization's supervisor support, clarity of purpose and training to improve the usefulness of the Regional Financial Accounting System. This study uses behavioral factors as the Organization of Independent Variables and Regional Financial Accounting System as Dependent Variables.

The samples were as many as 15 government agencies in the town of Kediri using sample adjustment. Questionnaires were distributed 100 kuesioner number and returned to the author of a number of 75 questionnaire. Data already entered if using multiple linear regression.

The results of data processing are superior support variable has a value of 3.438 t ₌ greater than t table is (3.438 > 2.042) with a p-value of 0.001 is accepted at significance level of 5% (p < 0.05). A positive value indicates a positive influence. This means that support supervisor affect the usefulness of financial accounting system daearah and H1 are accepted.

Variable clarity of purpose has ₌ 3,047 t value is greater than t table of 2.042 which is 3.047 > 2.042 or p-value of 0.003 is accepted at significance level of 5% (p < 0.05). That is the purpose of clarity effect on the area of ​​financial accounting system usability and H2 are accepted.

Training variables have the value of 1,346 t ₌ smaller than t table of 2.042 which is 1.346 < 2.042 or p-value of 0.183 was rejected at the 5% significance level (p > 0.05).
PERILAKU OPORTUNISTIK LEGISLATIF DALAM PENGANGGARAN DAERAH
Authors: MOCH. SHULTHONI
Published: March 2024

Artikel ini membahas mengenai bagaimana penyalahgunaan power dilakukan oleh legislatif terjadi dalam proses pengalokasian sumberdaya di anggaran, peran legislatif dalam penganggaran di Indonesia dengan menggunakan perspektif keagenan, dan perilaku oportunistik legislatif dalam penganggaran publik. Penganggaran publik adalah pencerminan dari kekuatan relatif dari berbagai budget actors yang memiliki kepentingan atau preferensi berbeda terhadap outcomes anggaran. Ketika politisi berperilaku korup maka hal ini menyangkut dengan keuntungan pribadi yang akan didapatkan melalui jumlah anggaran pemerintah. Artinya korupsi dan rent-seeking activities di pemerintahan berpengaruh terhadap jumlah dan komposisi pengeluaran pemerintah.

Perilaku oportunistik politisi dalam pembuatan keputusan investasi publik karena capital spending is highly descretionary, para politisi membuat keputusan-keputusan terkait dengan: (1) besaran anggaran investasi publik, (2) komposisi anggaran investasi publik tersebut,  (3) pemilihan proyek-proyek khusus dan lokasinya, dan (4) besaran rancangan setiap proyek investasi publik. Keputusan tersebut terkait dengan pemberian kontrak kepada pihak luar, yang dapat menghasilkan aliran rente berupa commissions. Representasi politik yang tidak layak dan institusi yang lemah mengakibatkan banyak peluang untuk melakukan political corruption. Perubahan posisi legislatif yang menjadi powerful menyebabkan legislatif memiliki power untuk merubah usulan anggaran yang diajukan eksekutif.
ANTARA FLAT DAN SLEDING
Authors: Dion Yanuarmawan
Published: March 2024

Small and Medium Enterprises (SME) products are home industry based on specific future of the culture, for example “Batik” is culture of Yogyakarta society, “Tahu Poo” is a specific of Kediri, “Tempe Sanan” is a specific future of Malang beside its apel, “Brem” is a specific future of Madiun, and other examples which can not be mentioned one by one. Capitalization is a big problem for SMEs, because when they needed loans in having an affor to develop their business, they felt difficult to get it. The existence of banks for SMEs were really hoped because bank had a role as financial intermediary between surplus unit and deficit unti. Beside, it was as an institution which could give a facility of payment. Loans which were given by the bank to the society. Inthis case, we called it “SMEs”. SMEs used several systems in payment, there are: Flat Interest System and Sliding Interest System. This research used quantitative method. The researchers used descriptive quantitative because the researchers intended to understand and analyze the comparison of flat interest system and sliding interest system. The data of this research used primary and secondary data. Primary data of this research was obtained through interviews the parties who were related tho the statements of the problems. The primary data source of this research were the SMEs owner (subject) who got loans from the bank and charged with Flat Interest System and Sliding Interest System. Secondary data of this research were SMEs’s Financial Statement
PENGARUH BEBERAPA VARIABEL FUNDAMENTAL TERHADAP PERTUMBUHAN MODAL SENDIRI
Authors: Wiwiek Kusumaning Asmoro
Published: March 2024

Dalam usaha mengembangkan industri makanan dan minuman ringan diperlukan pembiayaan yang cukup besar, dibutuhkan alternatif sumber pembiayaan. Ada dua jenis modal dalam perusahaan yaitu modal asing dan modal sendiri. Saat perusahaan ingin mempertahankan posisi solvabilitas dan likuiditas tentunya diperlukan modal sendiri yang memadai, namun demikian bila pertumbuhan modal sendiri berlebihan dapat memperkecil rentabilitas modal sendiri, pada lain hal dapat meningkatkan biaya modal. Pertumbuhan modal sendiri dapat dipengaruhi oleh beberapa variabel fundamental.

Penelitian ini dilakukan pada 21 populasi perusahaan consumer goods 16 sampel yang telah mencatatkan sahamnya di Bursa Efek Indonesia (BEI) selama kurun waktu lima tahun (2010-2015). Data yang digunakan di sini adalah pooling data time series pada periode tahun (2010-2015) terhadap perusahaan consumer goods yang tercatat di Bursa Efek Indonesia (BEI). Sumber data yang digunakan adalah data sekunder. Penelitian ini menggunakan uji regresi linier berganda menggunakan alat bantu SPSS, yang mana x1= Debt to Equity Ratio, x2= Earning Per Share, x3= beban bunga, x4= beban pajak,     x5 = ROE, x6= Pertumbuhan Penjualan, Y=Pertumbuhan Modal Sendiri.

Dari hasil penelitian hanya terdapat satu variabel yang mempunyai pengaruh yang signifikan terhadap pertumbuhan modal sendiri yaitu Return on Equity (ROE).  Sementara itu tiga variabel independent lainnya yaitu struktur modal, beban bunga dan pertumbuhan penjualan juga mempunyai pengaruh positif terhadap pertumbuhan modal sendiri meskipun tidak signifikan.  Sedangkan dua variabel independen lainnya yaitu Earnings per share dan beban pajak berpengaruh negatif terhadap pertumbuhan modal sendiri
PENGARUH MARKETING ONLINE DAN KEAKTIFAN KOMUNITAS TERHADAP PENINGKATAN PENJUALAN EMKM BATIK DI JEMBER
Authors: Dania Puspitasari  , Elok Fitriya
Published: March 2024

This study aims to determine the influence of online marketing and community activeness to increase sales. The

data obtained from the results of the distribution of questionnaires on batik craftsmen in the city of Jember.

Questionnaires obtained by researchers as much as 15 batik craftsmen in the city of Jember. Based on the results

of research proved that partially online marketing effect on increasing panjualan. Meanwhile, the livelihood of

the community has no effect on sales increase. This study can also prove that online marketing and community

cohectivity simultaneously affect the increasing sales of batik craftsmen in the city of Jember.
ANALISIS PENGARUH KUALITAS PRODUK DAN KUALITAS PELAYANAN TERHADAP KEPUASAN END USER PADA PT. BAROKAH JAYA SEJAHTERA
Authors: CHOIRUL HANA
Published: March 2024

Penelitian ini dilatar belakangi oleh meningkatnya jumlah penduduk yang semakin pesat serta

kebutuhan akan perumahan oleh masyarakat. Menjadikan peluang bisnis bagi pengembang (developer)

untuk dapat memperolah penjualan yang tinggi. Tingginya penjualan tidak dapat diperoleh dengan

mudah karena semakin banyaknya pesaing dalam bisnis property sehingga menarik peneliti untuk

mengkaji lebih dalam mengenai kualitas produk dan kualitas pelayanan pada PT. Barokah Jaya

Sejahtera. Melalui Kualitas produk dan Kualitas pelayanan dapat tercipta kepuasan End User. Tujuan

penelitian ini adalah Untuk Menguji dan menjelaskan pengaruh kualitas produk terhadap kepuasan

pelanggan, pengaruh kualitas pelayanan terhadap kepuasan pelanggan. Jenis penelitian yang digunakan

adalah penelitian survei yang bersifat penjelasan (explanatory research) dengan sampel sebanyak 51

responden. Metode analisis data yang digunakan adalah analisis statistik deskriptif dan analisis statistik

inferensial.

Hasil penelitian dengan menggunakan analisis statistik deskriptif menunjukan bahwa mean

tertinggi adalah kualitas produk dalam kategori baik. Mean kualitas pelayanan adalah baik dan Mean

Kepuasan pelanggan adalah baik. Hasil penelitian dengan menggunakan analisis statistik inferensial

menunjukkan bahwa terdapat pengaruh signifikan dan positif antara variabel kualitas Produk dengan

kepuasan End User, variabel kualitas pelayanan berpengaruh signifikan dan positif terhadap kepuasan

End User.
Neologisms in Mass Media on Selected CNN TV Programs during Coronavirus Epidemic: A Morphological Analysis
Authors: Al-Haj Eid Omar , Abu Guba Mohammed Nour , Abu Jweid Abdalhadi Nimer , Abuelhommus Shatha M.
Published: March 2024

This study aimed to investigate the neologisms used on selected CNN TV programs during the coronavirus epidemic. Adopting a descriptive method in analyzing the corpus of the study, we collected (286) neologisms. We analyzed them according to the types of word classes, their topics, and the morphological processes involved in forming these neologisms. The study revealed that 88 percent of the neologisms were nouns and the most prevalent morphological processes were compounding, affixation, and blending, respectively. The study also pointed out that 46 percent of the new words were medical neologisms. Findings revealed that the types of word classes and morphological processes abided by English word formation rules. Besides, all neologisms belonged to English open classes of words.
Paradigmas de autenticidade na interpretação das Variações de Llobet sobre o Op.15 de Sor
Authors: Souto Luciano , Silva Melo Adrielle Clara
Published: March 2024

Este artigo discute a autenticidade histórica e pessoal na abordagem interpretativa das Variaciones sobre un tema de Sor - Op. 15a (1908), de Llobet, pelas perspectivas de Kivy (1995) e Young (2013). O objetivo é compreender as transformações estruturais e estéticas desta obra decorrentes da passagem do tempo entre a composição de Sor e a composição de Llobet, capazes de modificar o seu sentido e impactar a sua interpretação. Para isso foi realizada uma análise comparativa entre as Variações de Llobet e a Op. 15a (c.a 1822-1825), de Sor, à luz da classificação semiótica (icônica, indexical e simbólica) da notação musical proposta por Treitler (1982) e Mammi (1999). Tal classificação permitiu que a notação musical e seus elementos significativos fossem contrapostos ao pensamento técnico, estético e musical dos compositores propiciando o reconhecimento de tais mudanças (estruturais e estéticas) na referida obra e fundamentando sua interpretação.
A case report of a family with developmental arrest of human prokaryotic stage zygote
Authors: Ma Tianzhong , Zhou Songxia , Xie Xuezhen , Chen Jingyao , Wang Jing , Zhang Guohong
Published: March 2024

To study the genetic variation leading to the arrest phenotype of pronuclear (PN) zygotes. We recruited a family characterized by recurrent PN arrest during in vitro fertilization (IVF) and intracytoplasmic sperm injection cycles (ICSI) and performed whole-exome sequencing for 2 individuals. The transcriptome profiles of PN-arrest zygotes were assessed by single-cell RNA sequencing analysis. The variants were then validated by PCR amplification and Sanger sequencing in the affected individuals and other family members. A family characterized by recurrent PN arrest during IVF and ICSI cycles were enrolled after giving written informed consent. Peripheral blood samples were taken for DNA extraction. Three PN-arrest zygotes from patient III-3 were used for single-cell RNA-seq as described. This phenotype was reproduced after multiple cycles of egg retrieval and after trying different fertilization methods and multiple ovulation regimens. The mutant genes of whole exon sequencing were screened and verified. The missense variant c. C1630T (p.R544W) in RGS12 was responsible for a phenotype characterized by paternal transmission. RGS12 controls Ca2+ oscillation, which is required for oocyte activation after fertilization. Single-cell transcriptome profiling of PN-arrest zygotes revealed defective established translation, RNA processing and cell cycle, which explained the failure of complete oocyte activation. Furthermore, we identified proximal genes involved in Ca2+ oscillation–cytostatic factor–anaphase-promoting complex (Ca2+ oscillation–CSF–APC) signaling, including upregulated CaMKII, ORAI1, CDC20, and CDH1 and downregulated EMI1 and BUB3. The findings indicate abnormal spontaneous Ca2+ oscillations leading to oocytes with prolonged low CSF level and high APC level, which resulted in defective nuclear envelope breakdown and DNA replication. We have identified an RGS12 variant as the potential cause of female infertility characterized by arrest at the PN stage during multiple IVF and ICSI.
ACE2 and TMPRSS2 expression in patients before, during, and after SARS-CoV-2 infection
Authors: Grisard Henrique Borges da Silva , Schörner Marcos André , Barazzetti Fernando Hartmann , Wachter Julia Kinetz , Valmorbida Manoela , Wagner Glauber , Fongaro Gislaine , Bazzo Maria Luiza
Published: March 2024

During the SARS-CoV-2 pandemic angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) were constantly under the scientific spotlight, but most studies evaluated ACE2 and TMPRSS2 expression levels in patients infected by SARS-CoV-2. Thus, this study aimed to evaluate the expression levels of both proteins before, during, and after-infection. For that, nasopharyngeal samples from 26 patients were used to measure ACE2/TMPRSS2 ex-pression via qPCR. Symptomatic patients presented lower ACE2 expression levels before and after the infection than those in asymptomatic patients; however, these levels increased during SARS-CoV-2 infection. In addition, symptomatic patients presented higher expression levels of TMPRSS2 pre-infection, which decreased in the following periods. In summary, ACE2 and TMPRSS2 expression levels are potential risk factors for the development of symptomatic COVID-19, and the presence of SARS-CoV-2 potentially modulates those levels.
Aerodynamic evaluation of surgical design for the stenosis correction of airway
Authors: Bao Wenjie , Liao Andi , Yu Pingping , Shen Juanya , Zhao Wenjing , Ding Lifeng
Published: March 2024

Introduction

Congenital tracheal stenosis (CTS) is a rare but life-threatening disease that can lead to respiratory dysfunction in children. Obstructive sleep apnea syndrome (OSAS) in children is characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction. Both of the diseases require surgical intervention. Although respective treatments of these two diseases are clear, there is a lack of literature discussing the surgical treatment of patients with CTS complicated by OSAS.

Methods

We conducted a patient-specific study of patient with CTS complicated by OSAS. Computer-aided design was used to simulate surgical correction under different surgical sequences. Computational fluid dynamics was used to compare the outcomes of different sequences.

Results

Aerodynamic parameters, pressure drop, velocity streamlines, wall shear stress (WSS), and the ratio of airflow distribution and energy loss rate were evaluated. An obvious interaction was found between the two diseases in different surgical sequences. The order of correction for CTS or OSAS greatly affected the aerodynamic parameters and turbulence flows downstream of tracheal stenosis and upstream of epiglottis. The CTS and OSAS had mutual influences on each other on the aerodynamic parameters, such as pressure drops and WSS.

Discussion

When evaluating the priority of surgical urgency of CTS and OSAS, surgeons need to pay attention to the state of both CTS and OSAS and the physiological conditions of patients. The aerodynamic performance of the uneven airflow distribution and the potential impact caused by the correction of CTS should be considered in surgical planning and clinical management.
The impact of COVID-19 school disruptions on children’s learning
Authors: Blackwell Courtney K. , Mansolf Maxwell , Deoni Sean C. L. , Ganiban Jody M. , Leve Leslie D. , Margolis Amy E. , McGrath Monica , Nozadi Sara S. , O’Shea T. Michael , Sherlock Phillip , Zhao Qi , LeWinn Kaja Z. ,   on behalf of program collaborators for Environmental influences on Child Health Outcomes Program
Published: March 2024

Introduction

National health policies to stop the spread of the COVID-19 virus in the US resulted in widespread school closures and disrupted learning in Spring 2020.

Methods

This study draws on unique individual-level data from n = 282 5–12 year olds enrolled in the NIH Environmental influences on Child Health Outcomes (ECHO) Research Program to investigate associations between caregiver-reported duration of Spring 2020 learning disruptions and academic achievement.

Results

Linear regression analyses estimated that children who experienced more than 4 weeks of instruction disruptions in Spring 2020 scored 4.5 points [95% CI: −8.77, −0.22] lower on age-normed math assessments compared to peers who had four or fewer weeks of disruption, adjusting for sociodemographic variables, pre-pandemic vocabulary, and COVID-19 family hardships and stress. No differences were found for reading. Children whose caregivers had higher levels of pandemic-related traumatic stress and lower educational attainment also had lower math scores, adjusting for all other covariates.

Discussion

Results suggest educators and schools focus additional attention on supporting math instruction for children who experienced extended learning disruptions.
Mixed reviews on diversity initiatives: toward an institutional change model for Black faculty in engineering and computing
Authors: Miles Monica L. , McGee Ebony O. , Botchway Portia
Published: March 2024

Introduction

Universities across the United States have implemented initiatives to enhance diversity in science, technology, engineering, and mathematics (STEM) fields, focusing on improving outcomes for racially minoritized students. While many diversity initiatives target undergraduate programs, there is a gap in support for STEM graduate students. Recognizing the persistent underrepresentation of racially diverse populations in STEM, the Biden-Harris Administration launched the “Raise the Bar: STEM Excellence for All Students” initiative, aiming to bolster STEM education nationwide. Foundations like the Sloan Foundation have developed pathways programs for STEM students, extending support into graduate school and the professoriate. The success of diversity initiatives often hinges on the participation and endorsement of underrepresented STEM faculty.

Methods

This study investigates the perspectives of twenty-nine Black engineering and computing faculty regarding diversity initiatives within their respective departments. Grounded theory methodology guided the qualitative analysis, enabling a deeper understanding of the racialized diversity management framework. Drawing on institutional racism perspectives, the study aimed to develop a theoretical framework elucidating institutional engagement with and implementation of diversity initiatives in engineering education.

Results

The participants’ perspectives on diversity initiatives reflected features of organizational change. Three types of organizational environments emerged: 1) stagnant, characterized by aspirational commitments to diversity; 2) moderate, where underrepresented populations are recruited but expected to assimilate into the dominant culture; and 3) transformational, representing organizations taking significant steps towards creating equitable environments. The narratives of the study participants shed light on the varying effectiveness of efforts to increase the representation of successful Black students and faculty in engineering academia.

Discussion

The findings underscore the importance of understanding organizational contexts and dynamics in shaping the outcomes of diversity initiatives. By delineating the racialized diversity management framework, this study provides insights into the complexities of institutional engagement with diversity in engineering education. Addressing the challenges identified, particularly in environments characterized as stagnant or moderate, is crucial for advancing equity and inclusion in STEM fields. Effective diversity initiatives must go beyond recruitment efforts to create transformative, equitable environments conducive to the success of racially minoritized students and faculty in engineering academia.
Exploration of carbon reduction in new municipal power systems
Authors: Ye Jichao , Zhang Hanbing , Hu Xinwei , Feng Hua , Xu Yonghai , Ji Aoying
Published: March 2024

In response to China’s goal of “carbon peak and carbon neutrality”, a large number of new energy sources are connected to the power grid, and Chinese cities are also accelerating the construction of new power systems led by new energy. Taking Lishui City as an example, this paper constructs a low-carbon emission reduction evaluation system to evaluate the carbon reduction effectiveness of the new power system. This paper first introduces the basic technical characteristics of the new power system, and introduces in detail the key technologies involved in the construction of the new power system in Lishui. Then, the projects implemented by Lishui City in promoting the new power system and the current achievements were briefly summarized. After that, a new electric carbon traceability model of Lishui power system was constructed to carry out carbon traceability and carbon tracking for the municipal power grid. Finally, a low-carbon emission reduction evaluation system was constructed, and a number of evaluation indicators were proposed to evaluate the carbon reduction effectiveness of Lishui’s new power system, and the zero-carbon evaluation index was calculated through the historical data of Lishui, and the results showed that the new power system in Lishui City achieved remarkable results in carbon reduction and emission reduction.
Electricity consumption optimization of power users driven by a dynamic electric carbon factor
Authors: Yang Yuyao , Pan Feng , Li Jinli , Ji Yilin , Zhong Lihua , Zhang Jun
Published: March 2024

In light of the escalating concerns surrounding climate change and air quality degradation, the imperative for energy conservation and emission reduction has garnered widespread attention. Given that factories represent a significant portion of electricity consumption within the power network, a comprehensive analysis of the electricity consumption behavior of energy-intensive enterprises becomes paramount. To meticulously dissect the electricity consumption patterns of energy-intensive enterprises, this paper categorizes them into four distinct production modes: 24-hour all-day production factories, pure daytime production factories, pure nighttime production factories, and environmentally friendly peaking production factories. Employing the dynamic electricity–carbon factor as a guiding force, the analysis encompasses electricity consumption, tariff expenditure, peaking costs, carbon emissions, and comfort levels associated with each production method throughout the year. A delicate equilibrium is sought among multiple objectives, aiming to optimize the user experience while simultaneously mitigating costs and carbon emissions. Furthermore, this paper conducts a comparative analysis of each objective, employing single-objective genetic algorithms and the interior point method. The resultant findings serve as invaluable insights for business users, aiding in informed decision-making processes.
Modeling and analysis of distribution network with photovoltaic cells based on Markov global sensitivity
Authors: Hu Tingting , Zhang Bai , Liu Pengyuan , Chang Xingzhi
Published: March 2024

When multiple distributed PV (photovoltaic) systems are integrated into multiple nodes of the distribution network, this will lead to the significant influence of the grid-tied node voltage of the power distribution network resulting from the uncertainty of PV power. Therefore, this aspect needs to be further studied in terms of how to effectively characterize the uncertainty of the voltage influence in a grid-tied multi-PV system distribution network. Focusing on this problem, a modeling and analysis method for distribution networks with PV cells based on Markov global sensitivity is proposed in this paper. Firstly, a global Markov chain is constructed using the Markov chain and the power flow equation to model the uncertainty of PV power. Furthermore, a Markov global sensitivity function is proposed to characterize the influence degree of the voltage on the distribution network nodes while multi-point PV system are grid-tied to system. The case study results show that the uncertainty model of multi-point PV grid-connection can be effectively constructed using the proposed method in this paper, and the uncertainty influence analysis is accurate. This is of great significance for grid connection planning and the optimization control of new energy systems, as well as for the new energy consumption increase.
Spatiotemporal dynamic changes in transpiration in the shoot sheath and its relation to water transportation during rapid growth of Moso bamboo
Authors: Li Juan , Chen Lei , Wang Jinge , Xu Junlei , Zheng Huifang , Bai Yucong , Cheng Zhanchao , Mu Shaohua , Gao Jian
Published: March 2024

Introduction

Transpiration is the driving force of water transport, which plays a crucial role in the rapid growth of bamboo shoots. Nonetheless, the transpiration changes that occur in the shoot sheath of Moso bamboo during the leafless stage and the physiological processes involved in water transport from the mother bamboo to bamboo shoots are not completely understood.

Methods

This study investigated the temporal dynamics of the transpiration rate (Tr) and stomatal conductance (gs) of the sheaths from bamboo shoots to culms and diurnal variations in Tr and gs as well as the spatial dynamics of Tr and gs in various parts of the shoot sheaths. Water distribution patterns in bamboo shoots were analyzed using the isotope tracer method, and the water transportation path in bamboo shoots was determined by soaking the shoots in fuchsine dye solution.

Results

We observed that the Tr was higher in bamboo shoots at heights of 4 and 7 m compared to that at 0.5, 1, 2, and 13 m, with rates ranging from 6.8 mmol/m2/s1 to 8.3 mmol/m2/s. Additionally, the Tr and gs of the shoot sheath were lower at noon, but higher in the morning and evening. The Tr in the lower parts of the culm sheath was higher than that that in the upper part (height: 0.5–4 m). However, when injected into the mother bamboo, D2O was not immediately transported to the shoots via the mother culms but was transported upward through the vascular bundle, with a larger vascular bundle near the pulp cavity transporting high volumes of water.

Discussion

These findings provide the foundation for further studies on the rapid growth of Moso bamboo and establish a theoretical basis for water management during its shoot developmental period.
The predictive value of PD-L1 expression in response to anti-PD-1/PD-L1 therapy for biliary tract cancer: a systematic review and meta-analysis
Authors: Yoon Seung Bae , Woo Sang Myung , Chun Jung Won , Kim Dong Uk , Kim Jaihwan , Park Joo Kyung , So Hoonsub , Chung Moon Jae , Cho In Rae , Heo Jun
Published: March 2024

Background

Recently, anti-programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immunotherapy offers promising results for advanced biliary tract cancer (BTC). However, patients show highly heterogeneous responses to treatment, and predictive biomarkers are lacking. We performed a systematic review and meta-analysis to assess the potential of PD-L1 expression as a biomarker for treatment response and survival in patients with BTC undergoing anti-PD-1/PD-L1 therapy.

Methods

We conducted a comprehensive systematic literature search through June 2023, utilizing the PubMed, EMBASE, and Cochrane Library databases. The outcomes of interest included objective response rate (ORR), disease control rate (DCR), progression-free survival (PFS), and overall survival (OS) according to PD-L1 expression. Subgroup analyses and meta-regression were performed to identify possible sources of heterogeneity.

Results

A total of 30 studies was included in the final analysis. Pooled analysis showed no significant differences in ORR (odds ratio [OR], 1.56; 95% confidence intervals [CIs], 0.94-2.56) and DCR (OR, 1.84; 95% CIs, 0.88-3.82) between PD-L1 (+) and PD-L1 (-) patients. In contrast, survival analysis showed improved PFS (hazard ratio [HR], 0.54, 95% CIs, 0.41-0.71) and OS (HR, 0.58; 95% CI, 0.47-0.72) among PD-L1 (+) patients compared to PD-L1 (-) patients. Sensitivity analysis excluding retrospective studies showed no significant differences with the primary results. Furthermore, meta-regression demonstrated that drug target (PD-1 vs. PD-L1), presence of additional intervention (monotherapy vs. combination therapy), and PD-L1 cut-off level (1% vs. ≥5%) significantly affected the predictive value of PD-L1 expression.

Conclusion

PD-L1 expression might be a helpful biomarker for predicting PFS and OS in patients with BTC undergoing anti-PD-1/PD-L1 therapy. The predictive value of PD-L1 expression can be significantly influenced by diagnostic or treatment variables.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO, identifier CRD42023434114.
Deciphering the developmental trajectory of tissue-resident Foxp3+ regulatory T cells
Authors: Alvarez Fernando , Liu Zhiyang , Bay Alexandre , Piccirillo Ciriaco A.
Published: March 2024

Foxp3+ TREG cells have been at the focus of intense investigation for their recognized roles in preventing autoimmunity, facilitating tissue recuperation following injury, and orchestrating a tolerance to innocuous non-self-antigens. To perform these critical tasks, TREG cells undergo deep epigenetic, transcriptional, and post-transcriptional changes that allow them to adapt to conditions found in tissues both at steady-state and during inflammation. The path leading TREG cells to express these tissue-specialized phenotypes begins during thymic development, and is further driven by epigenetic and transcriptional modifications following TCR engagement and polarizing signals in the periphery. However, this process is highly regulated and requires TREG cells to adopt strategies to avoid losing their regulatory program altogether. Here, we review the origins of tissue-resident TREG cells, from their thymic and peripheral development to the transcriptional regulators involved in their tissue residency program. In addition, we discuss the distinct signalling pathways that engage the inflammatory adaptation of tissue-resident TREG cells, and how they relate to their ability to recognize tissue and pathogen-derived danger signals.
Complete remission in a pretreated, microsatellite-stable, KRAS-mutated colon cancer patient after treatment with sintilimab and bevacizumab and platinum-based chemotherapy: a case report and literature review
Authors: He Lijuan , Li Haiyuan , Wang Yunpeng , Li Weidong , Gao Lei , Xu Bo , Hu Jike , He Puyi , Pu Weigao , Sun Guodong , Wang Zhuanfang , Han Qinying , Liu Ben , Chen Hao
Published: March 2024

Metastatic colon cancer remains an incurable disease, and it is difficult for existing treatments to achieve the desired clinical outcome, especially for colon cancer patients who have received first-line treatment. Although immune checkpoint inhibitors (ICIs) have demonstrated durable clinical efficacy in a variety of solid tumors, their response requires an inflammatory tumor microenvironment. However, microsatellite-stable (MSS) colon cancer, which accounts for the majority of colorectal cancers, is a cold tumor that does not respond well to ICIs. Combination regimens open the door to the utility of ICIs in cold tumors. Although combination therapies have shown their advantage even for MSS colon cancer, it remains unclear whether combination therapies show their advantage in patients with pretreated metastatic colon cancer. We report a patient who has achieved complete remission and good tolerance with sintilimab plus bevacizumab and platinum-based chemotherapy after postoperative recurrence. The patient had KRAS mutation and MSS-type colon cancer, and his PD-1+CD8+ and CD3−CD19−CD14+CD16−HLA-DR were both positive. He has achieved a progression-free survival of 43 months and is still being followed up at our center. The above results suggest that this therapeutic regimen is a promising treatment modality for the management of pretreated, MSS-type and KRAS-mutated metastatic colorectal cancer although its application to the general public still needs to be validated in clinical trials.
Optimizing cryopreservation conditions for use of fucosylated human mesenchymal stromal cells in anti-inflammatory/immunomodulatory therapeutics
Authors: Gil-Chinchilla Jesús I. , Bueno Carlos , Martínez Carlos M. , Ferrández-Múrtula Ana , García-Hernández Ana M. , Blanquer Miguel , Molina-Molina Mar , Zapata Agustín G. , Sackstein Robert , Moraleda Jose M. , García-Bernal David
Published: March 2024

Mesenchymal stem/stromal cells (MSCs) are being increasingly used in cell-based therapies due to their broad anti-inflammatory and immunomodulatory properties. Intravascularly-administered MSCs do not efficiently migrate to sites of inflammation/immunopathology, but this shortfall has been overcome by cell surface enzymatic fucosylation to engender expression of the potent E-selectin ligand HCELL. In applications of cell-based therapies, cryopreservation enables stability in both storage and transport of the produced cells from the manufacturing facility to the point of care. However, it has been reported that cryopreservation and thawing dampens their immunomodulatory/anti-inflammatory activity even after a reactivation/reconditioning step. To address this issue, we employed a variety of methods to cryopreserve and thaw fucosylated human MSCs derived from either bone marrow or adipose tissue sources. We then evaluated their immunosuppressive properties, cell viability, morphology, proliferation kinetics, immunophenotype, senescence, and osteogenic and adipogenic differentiation. Our studies provide new insights into the immunobiology of cryopreserved and thawed MSCs and offer a readily applicable approach to optimize the use of fucosylated human allogeneic MSCs as immunomodulatory/anti-inflammatory therapeutics.
Upadacitinib sustained-release tablets for the treatment of chronic refractory gouty arthritis: a case report and literature review
Authors: Yu Lishi , Huang Weidong , Lv Honghua , Jin Lie , Lei Wenhui
Published: March 2024

Background

Gouty arthritis (GA) is a crystal-related joint disease caused by the deposition of monosodium urate (MSU) crystals, directly associated with hyperuricemia resulting from purine metabolism disorder and/or reduced uric acid excretion. Acute attacks of typical gouty arthritis are generally relieved through the clinical use of NSAIDs, colchicine, or glucocorticoids. However, managing patients with chronic refractory gout poses challenges due to complications such as multiple tophi, gouty nephropathy, diabetes, and gastrointestinal bleeding. While there have been numerous studies on gout in recent years, research specifically regarding chronic refractory gout remains limited. The management of such cases still faces several unresolved issues, including recurrent disease flare-ups and poor patient compliance leading to inadequate drug utilization and increased risk of side effects. In this report, we present a case of successful improvement in chronic refractory gouty arthritis using the biologic agent upadacitinib sustained-release tablets.

Case presentation

Our case report involves a 53 years-old Asian patient with recurrent gouty arthritis who had a history of over 20 years without regular treatment, presenting with tophi and an increasing number of painful episodes. During hospitalization, various analgesics and anti-inflammatory drugs provided inadequate relief, requiring the use of steroids to alleviate symptoms. However, tapering off steroids proved challenging. We decided to add upadacitinib sustained-release tablets to the treatment regimen, which ultimately improved the patient’s condition. After 6 months of follow-up, the patient has not experienced any further acute pain episodes.

Conclusion

This case highlights the potential therapeutic effect of upadacitinib sustained-release tablets during the acute phase of chronic refractory gouty arthritis.
GEO dataset mining analysis reveals novel Staphylococcus aureus virulence gene regulatory networks and diagnostic targets in mice
Authors: Xu Guangyu , Yang Yue , Lin Yan , Bai Yu
Published: March 2024

Staphylococcus (S.) aureus infection is a serious, worldwide health concern, particularly in many communities and hospitals. Understanding the S. aureus pathogenetic regulatory network will provide significant insights into diagnostic target screening to improve clinical treatment of diseases caused by S. aureus. We screened differentially expressed genes between normal mice and S. aureus-infected mice. We used the Gene Expression Omnibus (GEO) DataSets database for functional analysis (GO-analysis) and the DAVID and KEGG databases for signaling pathway analyses. We next integrated the gene and pathway analyses with Transcriptional Regulatory Element Database (TRED) to build an antimicrobial resistance gene regulatory network of S. aureus. We performed association analysis of network genes and diseases using DAVID online annotation tools. We identified a total of 437 virulence genes and 15 transcription factors (TFs), as well as 444 corresponding target genes, in the S. aureus TF regulatory network. We screened seven key network nodes (Met, Mmp13, Il12b, Il4, Tnf, Ptgs2, and Ctsl), four key transcription factors (Jun, C3, Spil, and Il6) and an important signaling pathway (TNF). We hypothesized that the cytokine activity and growth factor activity of S. aureus are combinatorically cross-regulated by Met, Mmp13, Il12b, Il4, Tnf, Ptgs2, and Ctsl genes, the TFs Jun, C3, Spi1, and Il6, as well as the immune response, cellular response to lipopolysaccharide, and inflammatory response. Our study provides information and reference values for the molecular understanding of the S. aureus pathogenetic gene regulatory network.
Evaluation of partial volume correction and analysis of longitudinal [18F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models
Authors: Sanabria Bohórquez Sandra M. , Baker Suzanne , Manser Paul T. , Tonietto Matteo , Galli Christopher , Wildsmith Kristin R. , Zou Yixuan , Kerchner Geoffrey A. , Weimer Robby , Teng Edmond
Published: March 2024

Purpose

We evaluated the impact of partial volume correction (PVC) methods on the quantification of longitudinal [18F]GTP1 tau positron-emission tomography (PET) in Alzheimer's disease and the suitability of describing the tau pathology burden temporal trajectories using linear mixed-effects models (LMEM).

Methods

We applied van Cittert iterative deconvolution (VC), 2-compartment, and 3-compartment, and the geometric transfer matrix plus region-based voxelwise methods to data acquired in an Alzheimer's disease natural history study over 18 months at a single imaging site. We determined the optimal PVC method by comparing the standardized uptake value ratio change (%ΔSUVR) between diagnostic and tau burden–level groups and the longitudinal repeatability derived from the LMEM. The performance of LMEM analysis for calculating %ΔSUVR was evaluated in a natural history study and in a multisite clinical trial of semorinemab in prodromal to mild Alzheimer's disease by comparing results to traditional per-visit estimates.

Results

The VC, 2-compartment, and 3-compartment PVC methods had similar performance, whereas region-based voxelwise overcorrected regions with a higher tau burden. The lowest within-subject variability and acceptable group separation scores were observed without PVC. The LMEM-derived %ΔSUVR values were similar to the per-visit estimates with lower variability.

Conclusion

The results indicate that the tested PVC methods do not offer a clear advantage or improvement over non-PVC images for the quantification of longitudinal [18F]GTP1 PET data. LMEM offers a robust framework for the longitudinal tau PET quantification with low longitudinal test–retest variability.

Clinical trial registration

NCT02640092 and NCT03289143.
Optimizing event-based neural networks on digital neuromorphic architecture: a comprehensive design space exploration
Authors: Xu Yingfu , Shidqi Kevin , van Schaik Gert-Jan , Bilgic Refik , Dobrita Alexandra , Wang Shenqi , Meijer Roy , Nembhani Prithvish , Arjmand Cina , Martinello Pietro , Gebregiorgis Anteneh , Hamdioui Said , Detterer Paul , Traferro Stefano , Konijnenburg Mario , Vadivel Kanishkan , Sifalakis Manolis , Tang Guangzhi , Yousefzadeh Amirreza
Published: March 2024

Neuromorphic processors promise low-latency and energy-efficient processing by adopting novel brain-inspired design methodologies. Yet, current neuromorphic solutions still struggle to rival conventional deep learning accelerators' performance and area efficiency in practical applications. Event-driven data-flow processing and near/in-memory computing are the two dominant design trends of neuromorphic processors. However, there remain challenges in reducing the overhead of event-driven processing and increasing the mapping efficiency of near/in-memory computing, which directly impacts the performance and area efficiency. In this work, we discuss these challenges and present our exploration of optimizing event-based neural network inference on SENECA, a scalable and flexible neuromorphic architecture. To address the overhead of event-driven processing, we perform comprehensive design space exploration and propose spike-grouping to reduce the total energy and latency. Furthermore, we introduce the event-driven depth-first convolution to increase area efficiency and latency in convolutional neural networks (CNNs) on the neuromorphic processor. We benchmarked our optimized solution on keyword spotting, sensor fusion, digit recognition and high resolution object detection tasks. Compared with other state-of-the-art large-scale neuromorphic processors, our proposed optimizations result in a 6× to 300× improvement in energy efficiency, a 3× to 15× improvement in latency, and a 3× to 100× improvement in area efficiency. Our optimizations for event-based neural networks can be potentially generalized to a wide range of event-based neuromorphic processors.