bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnosa Gangguan Perkembangan Anak Dengan Metode Fuzzy Expert System
Authors: Arisandi Diki , Puspitasari Ira , Annisah Annisah
Published: October 2018

Abstrak- Anak-anak dibawah umur 10 tahun merupakan fase yang sangat perlu diperhatikan perkembangannya oleh orang tua dan dibantu oleh pakar, apakah mengalami gangguan perkembangan atau tidak. Gangguan perkembangan anak dapat didiagnosis dari perilaku yang diperlihatkan oleh anak dengan cara observasi oleh seorang pakar psikologi anak. Hasil diagnosa dari observasi yang dilakukan beberapa pakar bisa saja berbeda. Hal ini membuat para orang tua menjadi kebingungan terhadap tindak lanjut yang harus dilakukan kepada anak mereka. Untuk mempermudah mendiagnosis gangguan perkembangan pada anak perlu adanya sebuah sistem pakar berbasis Fuzzy. Metode Fuzzy yang diterapkan didasari atas rentang logika berpikir manusia seperti dingin dan panas, tinggi dan rendah, dan lainnya. Diharapkan dengan adanya sistem pakar berbasis fuzzy ini, hasil diagnosa dapat menghasilkan solusi seperti nalar manusia dari sehingga didapatkan solusi untuk tindak lanjut pada gangguan anak. Kata kunci: Diagnosa, Fuzzy, Fungsi Keanggotaan, Gangguan perkembangan, Sistem Pakar. Abstract- Children under 10 years is a critical phase of their developmental and should be noticed by parents and assisted by experts, whether experiencing developmental disruption or not. Children developmental disruption can be diagnosed from behaviors shown by children by observation by a psychologist. Diagnosis results from observations made by some experts may be different. This makes the parents become confused about the follow-up to be done to their children. A Fuzzy-based expert system is needed to overcome the children developmental disruption. The applied Fuzzy method is based on the logical range of human thinking such as cold and hot, high and low, and others. With the fuzzy-based expert system, the diagnostic results can produce solutions such as human reasoning from that obtained a solution to following up on children disruption. Keywords: Diagnosis, Fuzzy, Membership Function, Developmental Disruption, Expert System.
Desain prototipe aplikasi sistem monitoring browser ponsel anak untuk menerapkan internet sehat dengan kontrol orang tua
Authors: Hidayat Taufik , Mansur Mansur , Rahmah Rahmah
Published: October 2018

Abstrak- Penggunaan internet dikalangan anak-anak saat ini sudah menjadi trend, bahkan banyak orang tua sudah memberikan ponsel android kepada anak-anak dalam melakukan komunikasi sehari-hari. Hal tersebut sangat berdampak kepada anak dalam pemanfaatan teknologi internet yang kurang sehat seperti mendapatkan data dan informasi melalui browsing internet tanpa pemantauan orang tua sehingga anak dengan mudah mendapatkan kata-kata atau informasi yang tidak layak dikonsumsi oleh anak tersebut. Penelitian ini bertujuan untuk mendesain aplikasi sistem monitoring browser ponsel anak untuk menerapkan internet sehat dengan kontrol orang tua menggunakan metode prototipe. Hasil penelitian tersebut berupa rancangan aplikasi monitoring broser anak yang dapat digunakan untuk memantau aktivitas browsing internet pada ponsel anak secara online pada platform android dengan otomatis mengirim pesan notifikasi kepada orang tua dan orang tua dapat memberikan respon atau balasan secara langsung ketika anak sedang mencoba melakukan aktivitas browsing internet yang tidak sehat.

Kata kunci: Kontrol orang tua, penelusuran aman, sistem monitoring, aktivitas penelusuran harian

Abstract- The use of the internet among children currently have become a trend, even many parents already gives android phones to children in doing everyday communication. It is so impacting to the child in the utilization of internet technologies that are less healthy as get data and information through browsing the internet without monitoring parents so children easily get words or information that is not feasible is consumed by the child. This research aims to design a monitoring system of the mobile browser app to implement a healthy internet parental control method using prototype. The results of such research in the form of a draft application monitoring these children which can be used to monitor the activities of internet browsing on mobile child online on the android platform with automatic notification to send a message to parents and parents can give a response or reply directly when the child was trying to do internet browsing activity that is not healthy.

Keywords: Parental Control, Safe Browsing, Monitoring System, Daily Browser Activity
Analisis dan Perancangan Situs Web Pemasaran Berbasis Intranet pada PT Radio Sonora
Authors: Wibowo Teguh Hari , Utami Viany
Published: October 2018

PT Radio Sonora merupakan anak perusahaan dari Kompas Gramedia Group yang bergerak dalam bidang saluran radio yang sudah cukup terkenal dan memiliki berbagai unit cabang di beberapa daerah di Indonesia. Penelitian ini bertujuan untuk menganalisis dan merancang situs web untuk bagian pemasaran pada PT Radio Sonora. Perancangan situs web ini menggunakan perancangan analisis terstruktur dengan metode waterfall model dan menggunakan flowchart diagram dan entity relationship diagram untuk menggambarkan sistem dari situs web yang akan dibuat. Situs web yang dibuat ini dirancang untuk meningkatkan kemampuan bagian pemasaran dalam mengelola informasinya.

Kata kunci—analisis, perancangan, situs web, intranet, pemasaran
Pemodelan Employee Self Service Sistem Sebagai Penunjang Human Resources Department
Authors: Oktavia Tanty
Published: October 2018

The background of this research is based on the operational needs in human resources department to organize all the data and business processes that occur in this division. The role of the Human Resources division significantly to manage labor resources that contribute to the implementation of the organization’s operations. The objectives in this research is to build a model of information system that can support the operation in employee management system, which consists of employees’ personal data, attendance report, and document about employees competence. The method of this research refers to model lifecycle database [1]. The results achieved in this study was the establishment of a model of information systems and database design that can support the operations of the Human Resources Department that can be operated and controlled directly by the relevant employees, so that the operational process can be performed effectively and efficiently.

Keywords: information system, human resources department, database lifecycle.
Sim Card Alarm for Android Smartphone
Authors: Ginanjar Rikip , Utomo Ridho
Published: October 2018

Since the first Android smartphones were released, many applications have been developed until today. One of them is security application. Security applications consist of several types of applications such as Antivirus, SIM Card Change Alarm, and Applocker. SIM Card Changed Alarm is a security application that has capability to monitor SIM Card change in Android smartphones. Although there are many SIM Card Change Alarm applications which are available in Google Playstore, there are many people who are not satisfied with this applications. It happens due to them only sends the SMS alert to the owner without locking the phone to prevent other people using it. The outcome of this research will have the same feature as SIM Card Change Alarm but with additional features such as locking the smartphone if the SIM Card has been changed, locking and unlocking remotely using SMS, triggering loud alarm, and calling-back to owner when the smartphone has been lost or stolen. The outcome expected for the Prifone Application is a userfriendly application which could be used by many people around the world and also is able to secure Android smartphones.

Index Terms – android, sim card alarm, security application
National Survey of Drug Information Centers practice: Pharmacoeconomic System at Ministry of Health Hospitals in Saudi Arabia
Authors: Alomi Yousef Ahmed , Alghamdi Saeed Jamaan , Alattyh Radi Abdullah
Published: October 2018

Objective: To explore the National Survey of Drug Information Centers practice in Saudi Arabia: PharmacoEconomic System at Ministry of Health Hospitals. Methods: It is a cross-sectional four months national survey of Drug Information Services at MOH. It contained ten domains with 181 questions designed by the authors. It was derived from Internal Pharmaceutical Federation (FIP), American Society of Health-System Pharmacists best practice guidelines. This survey was distributed to forty hospital pharmacies that run drug information services. In this study, the domain of Pharmacoeconomics System was explored and analyzed. It consisted of eight questions about the written policy and procedure and application methods for the PharmacoEconomic system in the drug information centers. All analysis was done through survey monkey system. Results: The survey was distributed to forty-five of hospitals, the response rate, was 40 (88.88%) hospitals. Of those; The Written policy and procedure of PharmacoEconomic did not exist in 26 (65%) hospitals. The definition types of PharmacoEconomic do not exist in 23 (57.5%) hospitals. Evaluation Processes of PharmacoEconomic Studies did not exist in 22 (55%) hospitals. The intensive analysis performed for all significant potential cost of the medications did not exist in 22(55%) hospitals. The evidence for using reported PharmacoEconomic data to improve medication use process and reduce cost rate, not found in 22 (55%) hospitals. Moreover, the Evidence of involvement of Drug Evaluation Processes not existed in 20 (50%) hospitals. Conclusion: the pharmacoeconomics system was week implementations of drug information centers practice. Revision of pharmacy strategic plan with pharmacoeconomics applications is required to improve the system at MOH hospital in the kingdom of Saudi Arabia.
Análisis del sector energético del Paraguay. Balance energético en energía útil 2011
Authors: Amarilla Raúl , Buzarquis Enrique , Riveros Estela , Fernández Félix , Blanco Gerardo , Barán Benjamín
Published: October 2018

El presente trabajo se enfoca en el análisis del sector energético paraguayo partiendo del primer Balance Energético en Energía Útil del Paraguay, elaborado mediante un proyecto conjunto entre la Itaipu Binacional y la Fundación Parque Tecnológico Itaipu - Paraguay, con la colaboración de la Fundación Bariloche - Argentina, tomando como año base el 2011. En el análisis se examina la situación del sector energético paraguayo en materia de energía hidroeléctrica, así como de los demás componentes de la Matriz Energética del Paraguay. El estudio compara los diferentes sectores de consumo de energía: Residencial, Industrial, Transporte, Agropecuario y Forestal, así como Comercial, Servicios y Público. El trabajo también presenta iniciativas en eficiencia energética que se han implementado en algunos sectores, destacando medidas que se esperan sean implementadas para incentivar el uso racional de la energía en todas sus fuentes. Finalmente, a modo de complemento, se exponen los principales resultados de la actualización al año 2013 del Balance Energético en Energía Útil empleado para la elaboración de la Prospectiva Energética Nacional, base para la formulación de la Política Energética Paraguay 2040
Representaciones sociales de la democracia en estudiantes colombianos: un análisis multidimensional y cartográfico
Authors: Ruiz Pérez José Ignacio Ruiz Pérez , Pineda Silva Angélica , Ever José López Ever José López
Published: October 2018

Este trabajo se propone conocer las representaciones sociales de la democracia presentes en estudiantes colombianos de carreras de educación superior, y la relación que estas guardan con las variables de victimización, pertenencia geográfica y sociodemográfica. Así mismo, se busca conocer la forma cómo se distribuye la valoración de la democracia a nivel geográfico puesto que las variables socioeconómicas y del conflicto armado inciden de forma diferencial en las regiones del país. Para ello, se cuenta con una muestra no aleatoria (n=3300) de carreras universitarias y técnicas-tecnológicas de 31 de los 32 departamentos del país, que respondieron un cuestionario cerrado compuesto, entre otras secciones, por una Escala de Representaciones Sociales de la Democracia y una Escala de Victimización. Entre los resultados se encontraron cuatro dimensiones de la democracia: valores,  aspectos electorales, desconfianza y corrupción. El posicionamiento de los sujetos en estas dimensiones estuvo relacionado con la clase entre un indicador de valoración de la democracia con la victimización criminal. social y las experiencias de victimización de forma compleja. En esta vía, una proyección cartográfica muestra que no hay una relación lineal     entre un indicador de valoración de la democracia con la victimización criminal.
Migración en Chile, una experiencia desde el proceso individual de la resiliencia
Authors: Ana Castro Ríos , Saavedra Guajardo Eugenio
Published: October 2018

El capítulo que se presenta a continuación, da cuenta de un estudio cualitativo, desde la perspectiva de la resiliencia, sobre el fenómeno de migración que se está produciendo en Chile; situación social que actualmente está configurando cambios importantes en la sociedad chilena. Se evidencia la experiencia individual de un sujeto, que desde los núcleos de significados asociados a riesgo, protección y conductas resilientes, describe como el proceso de migración lo ha transformado en una oportunidad de salir adelante y configura su presente. La migración refleja, hoy especialmente en nuestra América Latina, procesos de pobreza y desigualdad importantes y sostenidos, que el modelo económico imperante y el rol asumido por el Estado, agudizan implacablemente
Desempeño docente y satisfacción académica en estudiantes de educación secundaria.
Authors: Falcón Polanco Gesella Marlene
Published: October 2018

La presente investigación tuvo como objeto determinar la relación entre desempeño docente y satisfacción estudiantil. El trabajo presenta un diseño correlacional. La muestra estuvo conformada por 86 estudiante de la educación secundaria, los instrumentos utilizados fueron la encuesta para el desempeño docente elaborado y validado por juicio de expertos para esta investigación, consta de 10 ítems y tiene una escala de tipo Likert con una valoración de 1 a 4. Para evaluar satisfacción académica se utilizó la escala de Flores (2005) que consta de 30 ítems, dividida en 3 dimensiones: organización de la enseñanza, proceso de ense- ñanza aprendizaje, instalación e infraestructura la escala
Sentido del humor y empatía en maestras de primaria: reflexiones sobre su impacto en la enseñanza
Authors: Putrino Natalia Ines , Sasso Romina , Mustaca Alba
Published: October 2018

El objetivo de este trabajo es estudiar la relación entre los estilos de humor adaptativos y desadaptativos con la empatía cognitiva y afectiva en maestras.  Se trabajó con una muestra de 84 maestras argentinas, quienes respondieron a dos escalas: Test de empatía cognitiva y afectiva (TECA, López- Pérez, Fernández- Pinto & Abad, 2008), y a la versión adaptada al español y en la población argentina por Cayssials y Perez (2005) de la Escala de Estilos de Humor (Martin, 2003). Los resultados indican una relación significativa entre el tipo de humor afiliativo y las cuatro subescalas de empatía, como también entre el humor descalificación personal y el estrés empático.  Por otro lado, la dimensión adopción de perspectiva predice negativamente al humor agresivo y el estrés empático predice positivamente el humor descalificación personal. Estos resultados se discutirán en función de estudios previos y de la posible importancia que tienen para la docencia.
Comprensión de textos expositivos según modalidad de presentación y condiciones de respuesta
Authors: Campomanes Bravo Jesús Edgard
Published: October 2018

Se reporta un estudio cuyo objetivo es identificar la diferencia en la comprensión de textos expositivos según la modalidad de presentación y condiciones de respuesta en un grupo de estudiantes. El diseño del estudio es comparativo, debido a que se trata de comparar respuestas en un mismo grupo frente a dos modalidades de presentación del material. La muestra estuvo conformado por 80 estudiantes matriculados en la Facultad de Educación de la Universidad de Ciencias y Humanidades, 44 mujeres y 36 varones, y se utilizaron dos textos de divulgación científica, como material de comprensión. Los resultados evidencian que hay diferencias significativas a favor de la presentación escrita, respuesta escrita, es decir, que los estudiantes logran comprender mejor el texto cuando este es presentado de forma escrita. Se concluye que la modalidad de presentación escrita es la más adecuada para que los lectores puedan comprender mejor un texto, debido a la disponibilidad que tiene con el material y al ritmo para comprenderlo. En la presentación oral, tiene que ir al ritmo del locutor y no hay vuelta que dar, una vez escuchado el texto.
Estudio del bienestar psicológico, emocional y social en la vejez
Authors: Cortese Ricardo , Fernández Canales María Mercedes
Published: October 2018

Considerando el envejecimiento acelerado y el aumento de la esperanza de vida, se buscó identificar el tipo de bienestar (psicológico, emocional o social) que predominaba en adultos mayores y analizar si existían diferencias significativas entre el grupo de viejos-jóvenes y el de viejos-viejos definidos por Neugarten (1999). Se realizó un estudio de corte transversal, descriptivocomparativo y se trabajó con una muestra de N=218 participantes de ambos sexos de entre 65 y 98 años de edad de Buenos Aires. Se construyó un cuestionario socio- emográfico ad-hoc y se administró el Mental Health Continuum- Short Form de Keyes(Lupano, De la Iglesia, Castro & Keyes, 2016). Los resultados indicaron que tanto en la muestra general como en ambos grupos, el bienestar psicológico fue el predominante. Además, los viejos jóvenes obtuvieron puntuaciones más altas en el bienestar emocional, social y total en comparación con los viejos-viejos.
Barriers to Implementation of Building Information Modeling (BIM) to the Construction Industry: A Review
Authors: Ahmed Shakil
Published: October 2018

Construction industry is one of the largest economic sector in the world in 2017. And Building Information Modeling (BIM) is the powerful set of technology to design, construction and management has been strengthen the construction industry. BIM has significant benefits for the project lifecycle even after it‘s lifecycle but this benefits can‘t gain by the project because of failure to successful implementation of BIM technology to the construction industry. The main objectives of this study is to identify the most crucial barrier to implementation of BIM and develop a relative rank with their relative impact on this issue. The study was conducted by a comprehensive literature review and necessary data was collected by literature review also. A set of barrier was developed by the literature review containing 37 barrier which curb the implementation of BIM technology to the construction sector. Relative rank based on their frequency and relative impact was calculate for each barrier identified in the literature review. The five most crucial barrier to the implementation of BIM are B17 (Social and habitual resistance to change), B19 (Traditional methods of contracting), B3 (Training expenses and the learning curve are too expensive), B20 (High cost of software purchasing) and B33 (Lack of awareness about BIM). And the five most impactful barrier are B19 (Traditional methods of contracting), B17 (Social and habitual resistance to change), B33 (Lack of awareness about BIM), B2 (Unavailability of proper training on BIM) and B28 (Lack of BIM experts). To gain the tremendous benefits of BIM technology, it is necessary to overcome the barrier based on priority with the help of government and all the stakeholder of project.
"kapazitär" wie "autoritär" – Neue Adjektive auf "-itär"
Authors: Buchmann Franziska
Published: October 2018

Besides some well-established forms like autoritär 'authoritarian'; humanitär 'humanitarian'; new coinages ending with -itär can be found in German. These adjectives are closely related to nouns ending with -ität. From an etymological point of view; these formations are morphologically transparent. Not only are the adjectives new; but -itär emerges as a new suffix.
 
Dieser Beitrag ist ursprünglich im Peter-Lang-Verlag erschienen (https://www.ingentaconnect.com/contentone/plg/jwf/2018/00000002/00000002/art00001)
Die kusiete in Amos 9:7
Authors: Van Wyk W.C.
Published: October 2018

No abstract available.
Wat sê Maleagi van egskeiding?
Authors: Wolmarans H.P.
Published: October 2018

No abstract available.
Die psigologie van die bejaarde
Authors: Prins S.J.
Published: October 2018

No abstract available.
Vyftig jaar geskiedenis van die Christendom aan die Teologiese Fakulteit, Afdeling A van die Universiteit van Pretoria, 1917 tot 1967
Authors: Pont A.D.
Published: October 2018

No abstract available.
Boekbespreking
Authors: Koekemoer P.J. Theo
Published: October 2018

No abstract available.
Intra-Industry Trade and Determinant: Evidence for ASEAN-Australia and New Zealand in the Context of AANZFTA
Authors: Bano Sayeeda
Published: October 2018

This study examines the changing patterns and direction of trade between Association of South- East Asian Nations (ASEAN), Australia and New Zealand in the context of the ASEAN-Australia-New Zealand Free Trade Area/Agreement (AANZFTA) signed in 2010. It investigates the extent of ASEAN’s intra-industry trade with Australia and New Zealand at the 3-digit disaggregated SITC level for the period 1990 to 2014. The study includes an analysis of intra-industry trade indices of trade intensities, the marginal intra-industry trade and the econometric model to identify the determinants of intra-industry trade. The results show that trade in general has increased and intra-industry trade between ASEAN-Australia increased specifically in manufacturing. New Zealand has developed intra-industry trade in both the manufacturing and agriculture sectors. Marginal intra- industry results suggest that some industries transforming from inter-industry trade patterns to intra-industry trade. The results of regression analysis provide some support to the thesis that increase in IIT comes naturally with high average incomes of trade partners and large average market size. As a country’s level of income goes up and its standard of living rise, its citizens tend demand and consume more high quality differentiated products, leading to higher levels of intra-industry trade. This study differs from the existing literature in terms of its scope, methods and policy perspectives. The findings have policy relevance for the ongoing negotiations for a regional comprehensive economic partnership with ASEAN 10, India, China, Japan, Australia and New Zealand. It is reasonable to suggest that intra-industry trade be given due consideration in ongoing regional and bilateral trade negotiations for potential mutual gains from trade for a sustainable regional economic growth.
Reverse Logistics Network Problem using simulated annealing with and without Priority-algorithm
Authors: Benaissa Mounir , Slama Ilhem , Dhiaf Mohamed Mahjoub
Published: October 2018

In recent years, Reverse Logistics (RL) has become a field of importance for all organizations due to growing environmental concerns, legislation, corporate social responsibility and sustainable competitiveness. In Reverse logistics, the used or returned products are collected after their acquisition and inspected for sorting into the different categories. The next step is to disposition them for repair, remanufacturing, recycling, reuse or final disposal. Manufacturers may adopt reverse logistics by choice or by force, but they have to decide whether performing the activities themselves or outsourcing to a third party (Martin et al., 2010). Lourenço et al., (2003) described three main areas of improvement within the RL process. Firstly, companies can reduce the level of returns through the analysis of their causes. Secondly, they can work on the improvement of the return’s process and, thirdly, they can create value from the returns. This paper considers the multistage reverse Logistics Network Problem (mrLNP) proposed by Lee et al., (2008). With minimizing the total of costs to reverse logistics shipping cost. We will demonstrate the mrLNP model will be formulated as a three-stage logistics network model. Since such network design problems belong to the class of NP-hard problems we propose a Simulated Annealing (SA) and simulated annealing with priority (priSA) with special neighborhood search mechanisms to find the near optimal solution consisting of two stages. Computer simulations show the several numerical examples by using, SA, priSA and priGA(Genetic algorithm with priority-based encoding method) and effectiveness of the proposed method.
Passenger level of service estimation model for queuing systems at the airport
Authors: Kierzkowski Artur , Kisiel Tomasz , Pawlak Maria
Published: October 2018

This paper presents a model for the management of passenger service operations at airports by the estimation of a global index of the level of service. This paper presents a new approach to the scheduling of resources required to perform passenger service operations at airports. The approach takes into account the index of level of service as a quantitative indicator that can be associated with airport revenues. Taking this index into account makes it possible to create an operating schedule of desks, adapted to the intensity of checking-in passengers, and, as such, to apply dynamic process management. This offers positive aspects, particularly the possibility of improvement of service quality that directly translates into profits generated by the non-aeronautical activity of airports. When talking about level of service, there can be distinguish other important indicators that are considered very often (eg maximum queuing time, space in square meters). In this model, however, they are considered as secondary. Of course, space in square meters is important when designing a system. Here this system is already built and functioning. The concept of the model is the use of a hybrid method: computer simulation (Monte Carlo simulation) with multiple regression. This paper focuses on the presentation of a mathematical model used to determine the level of service index that provides new functionality in the current simulation model, as presented in the authors’ previous scientific publications. The mathematical model is based on a multiple regression function, taking into account the significance of individual elementary operations of passenger service at an air terminal.
The analysis of urban taxi carpooling impact from taxi GPS data
Authors: Xiao Qiang , He Ruichun , Ma Changxi
Published: October 2018

Taxi is an important part of urban passenger transportation system. The research and analysis of taxi trip behavior is the key to meet the demand of urban passenger transport and solve the traffic congestion problem. Based on the GPS data of taxis in Nanjing, the statistical method is used to analyze the taxi characteristics of the average number of passengers, the average passenger time, the no-load distance and the passenger distance. By using the double logarithmic coordinate, the trip distance and trip time of taxi passengers are analyzed, it is found that the average trip distance of taxi passengers is mainly concentrated in 3-20km, and the average trip time of taxi passengers is mainly concentrated in 10-30 minutes. Using the information entropy theory to construct the equilibrium model of taxi passenger-carrying point, and analyze the spatial distribution of taxi, it is found that the distribution of urban taxi is unbalanced. The peak clustering algorithm is used to determine the location of passenger gathering points, and the hot spot of taxi trip is analyzed, it is found that the hot spots of taxi trip are mainly concentrated in the central city of Nanjing. Combined with the results of urban taxi trip analysis, from the perspective of taxi and passenger, we found that the number of urban taxis, the passenger carrying rate of taxis, the duration period of passenger trip, the duration and distance of passenger trip and the location of passenger trip points will have an impact on the urban taxi carpooling in Nanjing. By using the probability model of urban taxi carpooling, this paper discusses and analyzes the influence of these factors on urban taxi carpooling. The research in this paper can provide a reference for the effective implementation of urban taxi carpooling policy.
Prices and Value of the Hunted Animals and Hunting Products in the Late Fifteenth and the Second Half of the Sixteenth Century in the Environment of the Ruler of the Grand Duchy of Lithuania
Authors: Zarankaitė-Margienė Toma
Published: October 2018

The essence of hunting as a historical phenomenon cannot be defined in the economic aspect alone. In the Middle Ages and in the Early Modern Period, it was a multi-faceted symbiotic relationship combining both the daily life of the Grand Duke of Lithuania, the economic life of the state, and even foreign policy. It also partially shaped the image of the sovereign and legitimated his power. Hunted animals provided meat, bone material, furs, skins, and other products necessary for the needs of the ruler’s court. This article represents the latest research on the prices and value of the hunted animals and the products made from them in late fifteenth century and the second half of the sixteenth century in the environment of the ruler of the Grand Duchy of Lithuania. The second part of the analysis reveals the variety and prices of different products made from the hunted animals and their use.
Judicial Culture at the Courts of Samogitia in the Early Seventeenth Century. Formulating a Problem. An Overview of the Manuscript Court Books (1600–1630)
Authors: Vilimas Darius
Published: October 2018

Research into juridical culture of the Grand Duchy of Lithuania has not been sufficiently addressed in general, and the Duchy of Samogitia at the end of the seventeenth century is not an exception in this context.
Juridical culture is a multi-faceted phenomenon in the life of “a nation of nobles” of that time, and it needs to be examined on a broader scale. In addition to other collections, the main part of the set of historical sources consists of the manuscript books of Samogitian castle and land courts kept in Collection No. 7 of the Manuscript Department of the Vilnius University Library.
Seventy-four manuscript books of Samogitian courts (1600–1630) have survived to the present time: two books of castle courts and 72 books of land courts. If the books of the castle court serve as an example of just a fragmentary activity, the books of the land court are highly multisided and represent diverse aspects of the life of the nobles.
The books of the land court of Samogitia of that period are divided into the groups of court acts (series A) and of court cases (series B). For the research into juridical culture, the books of the court case group, of which there are 47 units and which are further subdivided into the subgroups of proceedings and current affairs, are of greater interest.
Along with the collections of the noble families kept in a number of libraries and archives in Lithuania and abroad, the Samogitian court books offer a sufficient basis of sources for the examination of the juridical culture of the nobility at the beginning of the seventeenth century. It is therefore highly likely that the research will be productive and will reveal intriguing shifts in the mentality of the nobles. Meanwhile, the present paper is an introduction to a broader research problem.
Arsenate‐mediated G2 cell cycle arrest in U‐2OS cells involves phosphorylation of human polycomb protein 2 by p38 MAPK
Authors: Wu Wei , Zhou Hui , He Fei , Xiao Zhi , Jiang Yong , Zhao Ming
Published: October 2018

G2/M checkpoints ensure the proper timing of cell mitosis. We previously reported that p38 mitogen‐activated protein kinase (MAPK) activation is essential for stress‐induced G2 arrest in the U‐2OS osteosarcoma cell line, but the molecular mechanism was obscure. Here, using the T7 phage display system, we find p38 directly binds to human polycomb protein 2 (HPC2), and arsenate‐induced G2 arrest in U‐2OS cell is p38‐ and phosphorylation of HPC2‐dependent. Phosphorylation of HPC2 at threonine 495 is required for recruiting Ring1 and Rb family proteins to form the polycomb repressive complex (PRC), and PRC is required for arsenate‐induced downregulation of CDC2 expression. Thus, p38 MAPK regulates cell cycle progression through phosphorylation of HPC2 to mediate transcriptional repression, providing a mechanistic link for arsenate‐induced transcriptional silencing.
Treatment at low‐volume hospitals is associated with reduced short‐term and long‐term outcomes for patients with retroperitoneal sarcoma
Authors: Keung Emily Z. , Chiang Yi‐Ju , Cormier Janice N. , Torres Keila E. , Hunt Kelly K. , Feig Barry W. , Roland Christina L.
Published: October 2018

Background

Retroperitoneal sarcomas (RPS) are rare tumors for which complete surgical resection remains the mainstay of treatment. The objective of the current study was to determine the impact of hospital case volume on outcomes in patients with RPS.

Methods

A total of 6950 patients with primary RPS who underwent surgical resection were identified from the National Cancer Data Base (1998‐2011). Treating hospitals were classified by annual case volume; low‐volume hospitals (LVHs) and high‐volume hospitals (HVHs) were defined as those with ≤10 cases per year and >10 cases per year, respectively. Overall survival (OS) was compared using Kaplan‐Meier curves. Cox proportional hazard models were created to compare risks.

Results

Of the 1131 reporting hospitals, the majority (1127 hospitals; 99.6%) were LVHs treating the majority of patients (6270 patients; 90.2%). Patients treated at LVHs were more likely to have lower grade and smaller tumors, receive radiotherapy, and undergo incomplete macroscopic (R2) resection. Patients treated at HVHs had lower 30‐day readmission rates (1.8% vs 3.4%; P<.001), 30‐day (1.9% vs 3.1%; P=.004) and 90‐day (3.2% vs 5.7%; P=.007) mortality, longer median OS (76.2 months vs 64.2 months; P<.001), and higher 5‐year OS rates (58% vs 52%; P<.001). After controlling for age, sex, insurance status, tumor size, tumor grade, surgical resection margin status, and radiotherapy administration, treatment at an HVH was found to be independently associated with a reduced risk of death (hazard ratio, 0.77; 95% confidence interval, 0.65‐0.91 [P=.003]).

Conclusions

Primary RPS are rare tumors, and to our knowledge few surgeons and institutions have significant experience and expertise in their multidisciplinary management and surgical resection. Although additional studies are needed, patient outcomes may be impacted by the case volume and expertise of the treating facility.
Private practice outpatient fine needle aspiration clinic: A 2018 update
Authors: Abele John S.
Published: October 2018

This review updates a 2008 report on the establishment of a pathologist‐directed ultrasound‐guided fine needle aspiration (USGFNA) biopsy clinic in a private practice setting. During this time, ultrasound evaluation of the thyroid has evolved from simply sampling a nodule to a reliable cancer risk assessment (CRA). Because of perceived poor reliability in many local radiology thyroid ultrasound reports, first endocrinologists and then pathologists began performing their own ultrasound evaluations, cancer risk assessments, and USGFNAs. The present review covers a wide range of topics, including incorporating ultrasound data into a report, the uniqueness of the thyroid as an USGFNA target, artifact pseudocomplexity mimicking neoplasia, the pathologist’s ability to acquire thyroid cancer risk assessment expertise, and distinguishing a true thyroid nodule from a pseudonodule with appropriate documentation. The use of ultrasound does not change the core need for high‐level biopsy and smear‐making techniques. Two national courses offer advanced training and certification. Selection of mission‐appropriate ultrasound machines is discussed along with the pitfalls of purchase. Determining the location of a USGFNA clinic requires several considerations, as does the layout detail of the clinic interior for optimal patient comfort and experience. Ultrasound does not obviate the pathologist’s anticipation of patient concerns or of providing information, including revealing a cancer diagnosis. The goal of this review is to help guide the reader to successfully and beneficially bring the science of USGFNA to patients in an understandable and caring way.
Long noncoding RNA C21orf121/bone morphogenetic protein 2/microRNA‐140‐5p gene network promotes directed differentiation of stem cells from human exfoliated deciduous teeth to neuronal cells
Authors: Liu Jun , Zhang Zeng‐Yu , Yu Hong , Yang Ai‐Ping , Hu Ping‐Fang , Liu Zhuo , Wang Min
Published: October 2018

Previous studies have revealed that long noncoding RNA (lncRNA) and microRNA play a crucial role in autism, which is a childhood neurodevelopmental disorder with complicated genetic origins. Hence, the study concerns whether lncRNA C21orf121/bone morphogenetic proteins 2 (BMP2)/miR‐140‐5p gene network affects directed differentiation of stem cells from human exfoliated deciduous teeth (SHED) to neuronal cells in rats with autism. Autism models were successfully established. The neuron cells that differentiated from SHED cell were identified. The expression of lncRNA C21orf121, miR‐140‐5p, BMP2, Nestin, βIII‐tubulin, and microtubule‐associated protein 2 (MAP2) and the expression of neuron‐specific enolase (NSE) were examined. Besides, the gap junction (GJ) function of SHED, the intracellular free Ca
2+ concentration, and the social behavior and repetitive stereotyped movements of rats in autism were detected. The target relationship between lncRNA C21orf121 and miR‐140‐5p and that between miR‐140‐5p and BMP2 were also verified. Firstly, we successfully isolated SHED and identified the differentiated neurons of SHED. Besides, the expression of BMP2, MAP2, Nestin, βIII‐tubulin, NSE positive rate, GJ function, and intracellular free Ca
2+ concentration were increased with the upregulation of C21orf121 and downregulation of miR‐140‐5p, and accumulated time of repetitive stereotyped movements decreased and the frequency of social behavior increased. The results indicate that lncRNA C21orf121 as a competing endogenous RNA competes with BMP2 binding to miR‐140‐5p, thereby promoting SHED to differentiate into neuronal cells via upregulating BMP2 expression.
Prokaryotic SPHINX 1.8 REP protein is tissue‐specific and expressed in human germline cells
Authors: Manuelidis Laura
Published: October 2018

Small circular DNAs of 1.8 and 2.4 kb were initially discovered in highly infectious Creutzfeldt‐Jakob Disease (CJD) and scrapie particles from mammalian brain and cultured cells. Surprisingly, these protected cytoplasmic "SPHINX" DNAs contained replication (REP) initiation sequences resembling those of Acinetobacter phage viruses. An antibody was generated against a REP peptide encoded by the SPHINX 1.8 open reading frame (ORF) that was not present in mammals. It bound to a 41kd “spx1” protein on Western blots. Cytologically, spx1 concentrated in spinal cord synapses and pancreatic islet, but not exocrine cells. We hypothesized that circular SPHINX DNAs are ancient symbiotic elements that can participate in functional differentiation and neurodegeneration. Cell and tissue‐specific patterns of spx1 expression shown below implicate somatic cell‐to‐cell communication and differentiation functions that would favor conservation of SPHINX 1.8 in evolution. Remarkably, primary human oocytes and spermatogonia, but not mature sperm, displayed intense cytoplasmic spx1 signals that underscore the maternal inheritance of SPHINX 1.8. These findings should encourage investigations of unexplored networks of incorporated environmental infectious agents that can be key actors in progressive neurodegeneration, immunity, and cancer.
Preoperative albumin‐to‐globulin ratio predicts survival in patients with non‐small‐cell lung cancer after surgery
Authors: Zhang Hua , Zhang Bin , Zhu Kaikai , Wu Chao , Gao Liuwei , Sun Xiaoyan , Liu Chang , Wang Changli
Published: October 2018

The prognostic value of the preoperative albumin‐to‐globulin ratio (AGR) has not been investigated in non‐small‐cell lung cancer (NSCLC). Therefore, we aimed to assess the clinical applicability of the preoperative AGR to predict the prognosis in patients with NSCLC. We retrospectively enrolled 545 patients with stage I/II/III NSCLC who underwent surgery at our institution. The cutoff value for preoperative AGR was calculated by using a receiver operating characteristic curve analysis. A low AGR was associated with several clinicopathological variables related to tumor progression. In the multivariate analyses, the preoperative AGR was identified as an independent prognostic factor for disease‐free survival (DFS; P = 0.003) and overall survival (OS; P = 0.005). For patients with stage II and III with a preoperative AGR ≤ 1.43, the surgery plus chemotherapy group had a significantly longer DFS and OS than the surgery alone group (P = 0.002 and P = 0.001, respectively); however, a significant difference in DFS and OS between these two groups was not observed in patients with stage II and III with an AGR > 1.43 (P = 0.808 and P = 0.842, respectively). The preoperative AGR is an independent, significant predictor of DFS and OS in patients with NSCLC. Our results also demonstrate that the preoperative AGR might be a predictive marker of the therapeutic effect of postoperative chemotherapy in patients with stage II and III NSCLC.
Exploring and comparing of the gene expression and methylation differences between lung adenocarcinoma and squamous cell carcinoma
Authors: Yang Yang , Wang Meng , Liu Bao
Published: October 2018

Lung cancer is one of the most frequently diagnosed malignant tumors and the main reason for cancer‐related death around the world, whereas nonsmall cell lung cancer that consists two subtypes: lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) is responsible for an estimated 85% of all lung cancers. The current study aimed to explore gene expression and methylation differences between LUAD and LUSC. EdgeR was used to identify differentially regulated genes between normal and cancer in the LUAD and LUSC extracted from The Cancer Genome Atlas (TCGA), respectively, whereas SAM was used to find genes with differential methylation between normal and cancer in the LUAD and LUSC, respectively. Finally, Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis was performed to analyze the function which these genes enriched in. A total of 391 genes with opposite methylation patterns in LUAD and LUSC and four functional pathways were obtained (false discovery rate (FDR) < 0.1). These pathways mainly included fat digestion and absorption, phenylalanine metabolism, bile secretion, and so on, which were related to the airframe nutrition metabolic pathway. Moreover, two genes CTSE (cathepsin E) and solute carrier family 5 member 7 (SLC5A7) were also found, among which CTSE was overexpressed and hypomethylated in LUAD corresponding to normal lung tissues, whereas SLC5A7 showed the opposite in LUAD. In conclusion, this study investigated the differences between the gene expression and methylation patterns in LUAD and LUSC, and explored their different biological characteristics. Further understanding of these differences may promote the discovery and development of new, accurate strategies for the prevention, diagnosis, and treatment of lung cancer.
LncRNA PVT1 regulates growth, migration, and invasion of bladder cancer by miR‐31/CDK1
Authors: Tian Zhaoju , Cao Shuang , Li Cheng , Xu Mingfang , Wei Huaiqing , Yang Han , Sun Qiyu , Ren Qikui , Zhang Le
Published: October 2018

Purpose

The aim of our study was to validate the sway of long noncoding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1) on the metabolism and growth of bladder cancer cells by microRNA‐31 (miR‐31)/cyclin‐dependent kinase 1 (
CDK1).

Methods

The Gene Expression Omnibus database was used for analyzing the differentially expressed lncRNA and messenger RNA (mRNA) in bladder cancer tissues, with the highly expressed lncRNA PVT1 and mRNA CDK1 screened out. The expression level of PVT1 was detected by quantitative reverse‐transcription polymerase chain reaction, cell viability by Cell Counting Kit‐8 assay, cell proliferation and scratch by 5‐bromo‐2′‐deoxyuridine assay, cell migration and invasion by transwell assays, the expression level of
CDK1 by immunohistochemistry and western blot analysis, transcription factor targeting by dual‐luciferase assay, and the effect of PVT1 on bladder cancer growth by nude mice tumor formation experiment.

Results

LncRNA PVT1 and mRNA CDK1 had a higher expression in bladder cancer cells than that in neighboring tissues. Activity, proliferation, colony formation, migration, and invasion of bladder cancer cell were noticeably reduced by the PVT1 inhibitor than that of control group. PVT1 and
CDK1 have binding sites with miR‐31. When miR‐31 decreased, CDK1 mRNA and protein levels increased in vivo experiments in nude mice. When PVT1 was downregulated, the tumor size was significantly reduced and tumor proliferation was curbed. Immunohistochemistry showed that the positive rate of
CDK1 and
Ki‐67 decreased and the expression of miR‐31 increased after PVT1 was inhibited.

Conclusions

LncRNA PVT1 was overexpressed in bladder cancer cells, and it was downregulated miR‐31 to enhance CDK1 expression and facilitate bladder cancer cells proliferation, migration, and invasion.
MicroRNA‐133b suppresses bladder cancer malignancy by targeting TAGLN2‐mediated cell cycle
Authors: Zhao Feng , Zhou Liu‐Hua , Ge Yu‐Zheng , Ping Wen‐Wen , Wu Xin , Xu Zhong‐Le , Wang Min , Sha Zuo‐Liang , Jia Rui‐Peng
Published: October 2018

MicroRNAs (miRNAs), a group of small noncoding RNAs, are widely involved in the regulation of gene expression via binding to complementary sequences at 3′‐untranslated regions (3′‐UTRs) of target messenger RNAs. Recently, downregulation of miR‐133b has been detected in various human malignancies. Here, the potential biological role of miR‐133b in bladder cancer (BC) was investigated. In this study, we found the expression of miR‐133b was markedly downregulated in BC tissues and cell lines (5637 and T24), and was correlated with poor overall survival. Notably, transgelin 2 (TAGLN2) was found to be widely upregulated in BC, and overexpression of TAGLN2 also significantly increased risks of advanced TMN stage. We further identified that upregulation of miR‐133b inhibited glucose uptake, invasion, angiogenesis, colony formation and enhances gemcitabine chemosensitivity in BC cell lines by targeting TAGLN2. Additionally, we showed that miR‐133b promoted the proliferation of BC cells, at least partially through a TAGLN2‐mediated cell cycle pathway. Our results suggest a novel miR‐133b/TAGLN2/cell cycle pathway axis controlling BC progression; a molecular mechanism which may offer a potential therapeutic target.