bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of an α-Amylase from the Honeybee Chalk Brood Pathogen Ascosphaera apis
Authors: Li Jincheng , Liu Sen , Yang Chenjie , Keyhani Nemat O. , Pu Huili , Lin Longbin , Li Xiaoxia , Jia Peisong , Wu Dongmei , Pan Jieming , Stevenson Philip C. , Fernández-Grandon G Mandela , Zhang Liaoyuan , Chen Yuxi , Guan Xiayu , Qiu Junzhi
Published: November 2023

The insect pathogenic fungus, Ascosphaera apis, is the causative agent of honeybee chalk brood disease. Amylases are secreted by many plant pathogenic fungi to access host nutrients through the metabolism of starch, and the identification of new amylases can have important biotechnological applications. Production of amylase by A. apis in submerged culture was optimized using the response surface method (RSM). Media composition was modeled using Box–Behnken design (BBD) at three levels of three variables, and the model was experimentally validated to predict amylase activity (R2 = 0.9528). Amylase activity was highest (45.28 ± 1.16 U/mL, mean ± SE) in media composed of 46 g/L maltose and1.51 g/L CaCl2 at a pH of 6.6, where total activity was ~11-fold greater as compared to standard basal media. The enzyme was purified to homogeneity with a 2.5% yield and 14-fold purification. The purified enzyme had a molecular weight of 75 kDa and was thermostable and active in a broad pH range (> 80% activity at a pH range of 7–10), with optimal activity at 55 °C and pH = 7.5. Kinetic analyses revealed a Km of 6.22 mmol/L and a Vmax of 4.21 μmol/mL·min using soluble starch as the substrate. Activity was significantly stimulated by Fe2+ and completely inhibited by Cu2+, Mn2+, and Ba2+ (10 mM). Ethanol and chloroform (10% v/v) also caused significant levels of inhibition. The purified amylase essentially exhibited activity only on hydrolyzed soluble starch, producing mainly glucose and maltose, indicating that it is an endo-amylase (α-amylase). Amylase activity peaked at 99.38 U/mL fermented in a 3.7 L-bioreactor (2.15-fold greater than what was observed in flask cultures). These data provide a strategy for optimizing the production of enzymes from fungi and provide insight into the α-amylase of A. apis.
The Effects of 12-Week Traditional Thai Exercise (Ruesi Dadton) on Glycemic Control and Inflammatory Markers in Prediabetes: A Randomized Controlled Trial
Authors: Sawangwong Pornchai , Tungsukruthai Sucharat , Nootim Preecha , Sriyakul Kusuma , Phetkate Pratya , Pawa Kammal Kumar , Tungsukruthai Parunkul
Published: November 2023

Hyperglycemia and inflammation are hallmarks of the prediabetes stage, which has the potential to develop into diabetes mellitus. In this stage, lifestyle changes and exercise are recommended and have been shown to be effective. However, there has been insufficient study investigating the impact of Ruesi Dadton (RD) exercise on prediabetes. Therefore, this study aimed to investigate the effect of RD exercise on biomarkers of glycemic level including fasting plasma glucose (FPG), the 2 h oral glucose tolerance test (OGTT), hemoglobin A1C (HbA1C), the biomarkers of inflammation C-reactive protein (CRP) and interleukin 6 (IL-6), and body mass index (BMI) on prediabetes during 12-week RD exercise. A total of 64 participants were randomly assigned into two groups, RD and control (CON), and were tested by measuring their glycemic levels to screen for prediabetes. The RD group was instructed to perform 10 postures of RD exercise in 60 min, three times a week. The CON group received standard lifestyle recommendations that were not pharmacologically managed. The results reveal that the RD group experienced a significant decrease in FPG, OGTT, HbA1C, and IL-6 (p < 0.01), and BMI and CRP (p < 0.05) compared to the CON group. In addition, the CON group had considerably higher glycemic levels, BMI and IL-6 levels (p < 0.01). Our study demonstrates that RD could decrease the biomarkers of glycemic level and inflammation during 12 weeks of RD exercise in prediabetes. These findings suggest that RD exercise is an effective approach for reducing systemic inflammation and controlling glycemic levels in prediabetic patients.
Mobile Robot Path Planning Based on Kinematically Constrained A-Star Algorithm and DWA Fusion Algorithm
Authors: Liu Yanjie , Wang Chao , Wu Heng , Wei Yanlong
Published: November 2023

Path-planning research has been the key to mobile-robot-navigation technology. However, traditional path-planning algorithms have some shortcomings. To solve these problems, this paper proposes a fusion algorithm that combines the kinematical constrained A* algorithm with the Dynamic Window Approach (DWA) algorithm. The kinematical constrained A* algorithm can plan the global path, and then the DWA algorithm can plan the local path under the global path’s guidance. Firstly, combined with robot kinematics, we improve the node-expansion method and heuristic-function model of the A* algorithm, which improves the search efficiency, reduces the number of path bends and lowers the computational cost so that the path generated by the A* algorithm better meets the needs of robot motion. Secondly, we optimize the trajectory-evaluation function of the DWA algorithm so that the local paths planned by the DWA algorithm are smoother and more coherent, which is easier for robot-motion execution. Finally, we extract the key nodes from the global path planned by the A* algorithm to guide the DWA algorithm for local path planning and dynamic-obstacle avoidance and to make the local path closer to the global path. Through simulation and practical experiments, the effectiveness of the fusion algorithm proposed in this paper is verified.
Comprehensive Analysis of Microstructure and Hot Deformation Behavior of Al-Cu-Y-Mg-Cr-Zr-Ti-Fe-Si Alloy
Authors: Amer Sayed M. , Glavatskikh Maria V. , Barkov Ruslan Yu. , Churyumov Alexander Yu. , Loginova Irina S. , Khomutov Maxim G. , Pozdniakov Andrey V.
Published: November 2023

Low sensitivity to hot cracking is very important not only for casting but also for ingots of wrought alloys. Doping of Al-Cu-(Mg) alloys by eutectic forming elements provides an increasing resistance to hot cracking susceptibility, but it also leads to a decrease in plasticity. The quasi-binary alloys based on an Al-Cu-REM system with an atomic ratio of Cu/REM = 4 have a high solidus temperature, narrow solidification range and fine microstructure. The detailed investigation of microstructure, precipitation and hot deformation behavior, and mechanical properties of novel Al-Cu-Y-Mg-Cr-Zr-Ti-Fe-Si alloy was performed in this study. The fine Al8Cu4Y, needle-shaped Al11Cu2Y2Si2, compact primary (Al,Ti)84Cu6.4Y4.3Cr5.3 and Q (Al8Cu2Mg8Si6) phases were identified in the as-cast microstructure. Near-spherical coarse Al3(Zr,Y) and fine Al45Cr7 precipitates with a size of 60 nm and 10 nm were formed after 3 h of solution treatment at 580 °C. S′(Al2CuMg) precipitates with an average diameter of 140 nm, thickness of 6 nm and calculated volume fraction of 0.033 strengthened 36 HV during aging at 210 °C for 3 h. Three-dimensional hot processing maps demonstrated an excellent and stable deformation behavior at 440–540 °C and strain rates of 0.01–10 s−1. The rolled sheets had a good combination of yield strength (313 MPa) and plasticity (10.8%) in the recrystallized at 580 °C, with water quenched and aged at 210 °C for a 3 h state. The main calculated effect in the yield strength was contributed by Al45Cr7 precipitates.
Clinical Evaluation and Comparison of Two Microfluidic Antigenic Assays for Detection of SARS-CoV-2 Virus
Authors: Bottino Paolo , Pizzo Valentina , Castaldo Salvatore , Scomparin Elisabetta , Bara Cristina , Cerrato Marcella , Sisinni Sabrina , Penpa Serena , Roveta Annalisa , Gerbino Maria , Maconi Antonio , Rocchetti Andrea
Published: November 2023

Given the ongoing pandemic, there is a need to identify SARS-CoV-2 and differentiate it from other respiratory viral infections in various critical settings. Since its introduction, rapid antigen testing is spreading worldwide, but diagnostic accuracy is extremely variable and often in disagreement with the manufacturer’s specifications. Our study compared the clinical performances of two microfluidic rapid antigen tests towards a molecular assay, starting from positive samples. A total of 151 swabs collected at the Microbiology and Virology Laboratory of A.O. “SS Antonio e Biagio e C. Arrigo” (Alessandria, Italy) for the diagnosis of SARS-CoV-2 were simultaneously tested to evaluate accuracy, specificity, and agreement with the RT-qPCR results. Both assays showed an overall agreement of 100% for negative specimens, while positive accuracy comprised between 45.10% and 54.90%. According to the manufacturer’s instructions, the greatest correlation between the antigenic and molecular assays was observed for the subset with high viral load (18/19, 94.74%), while it dramatically decreased for other subsets. Moreover, the ability to differentiate between SARS-CoV-2 and Flu provides an added value and could be addressed in an epidemic context. However, an in-house validation should be performed due to differences observed in performance declared by manufacturers and those actually obtained.
Characterization of SARS-CoV-2 Variants in Military and Civilian Personnel of an Air Force Airport during Three Pandemic Waves in Italy
Authors: Equestre Michele , Marcantonio Cinzia , Marascio Nadia , Centofanti Federica , Martina Antonio , Simeoni Matteo , Suffredini Elisabetta , La Rosa Giuseppina , Bonanno Ferraro Giusy , Mancini Pamela , Veneri Carolina , Matera Giovanni , Quirino Angela , Costantino Angela , Taffon Stefania , Tritarelli Elena , Campanella Carmelo , Pisani Giulio , Nisini Roberto , Spada Enea , Verde Paola , Ciccaglione Anna Rita , Bruni Roberto
Published: November 2023

We investigated SARS-CoV-2 variants circulating, from November 2020 to March 2022, among military and civilian personnel at an Air Force airport in Italy in order to classify viral isolates in a potential hotspot for virus spread. Positive samples were subjected to Next-Generation Sequencing (NGS) of the whole viral genome and Sanger sequencing of the spike coding region. Phylogenetic analysis classified viral isolates and traced their evolutionary relationships. Clusters were identified using 70% cut-off. Sequencing methods yielded comparable results in terms of variant classification. In 2020 and 2021, we identified several variants, including B.1.258 (4/67), B.1.177 (9/67), Alpha (B.1.1.7, 9/67), Gamma (P.1.1, 4/67), and Delta (4/67). In 2022, only Omicron and its sub-lineage variants were observed (37/67). SARS-CoV-2 isolates were screened to detect naturally occurring resistance in genomic regions, the target of new therapies, comparing them to the Wuhan Hu-1 reference strain. Interestingly, 2/30 non-Omicron isolates carried the G15S 3CLpro substitution responsible for reduced susceptibility to protease inhibitors. On the other hand, Omicron isolates carried unusual substitutions A1803V, D1809N, and A949T on PLpro, and the D216N on 3CLpro. Finally, the P323L substitution on RdRp coding regions was not associated with the mutational pattern related to polymerase inhibitor resistance. This study highlights the importance of continuous genomic surveillance to monitor SARS-CoV-2 evolution in the general population, as well as in restricted communities.
Luminescence Thermometry with Nanoparticles: A Review
Authors: Đačanin Far Ljubica , Dramićanin Miroslav
Published: November 2023

Luminescence thermometry has emerged as a very versatile optical technique for remote temperature measurements, exhibiting a wide range of applicability spanning from cryogenic temperatures to 2000 K. This technology has found extensive utilization across many disciplines. In the last thirty years, there has been significant growth in the field of luminous thermometry. This growth has been accompanied by the development of temperature read-out procedures, the creation of luminescent materials for very sensitive temperature probes, and advancements in theoretical understanding. This review article primarily centers on luminescent nanoparticles employed in the field of luminescence thermometry. In this paper, we provide a comprehensive survey of the recent literature pertaining to the utilization of lanthanide and transition metal nanophosphors, semiconductor quantum dots, polymer nanoparticles, carbon dots, and nanodiamonds for luminescence thermometry. In addition, we engage in a discussion regarding the benefits and limitations of nanoparticles in comparison with conventional, microsized probes for their application in luminescent thermometry.
The Bonding State and Surface Roughness of Carbon-Doped TiZrN Coatings for Hydrogen Permeation Barriers
Authors: Kim Seonghoon , Kim Taewoo , Lee Seungjae , Lee Heesoo
Published: November 2023

We doped carbon into a TiZrN coating to reduce hydrogen permeability, and investigated the phase formation, bonding state, microstructure, and surface roughness of the carbon-doped TiZrN. The laser output for laser carburization was limited to a range of 20–50%. The grain size of the TiZrN coatings decreased from 26.49 nm before carburization to 18.31 nm after carburization. For XPS analysis, the sp2/sp3 ratio was 1.23 at 20% laser output, but it showed 2.64 at 40% laser output, which means that amorphous carbon was formed. As the grain size decreased with the formation of amorphous carbon, the surface microstructure of the carbon-doped TiZrN coatings transitioned to an intergranular structure, indicating the creation of amorphous carbon-embedded (Ti, Zr)(C, N) in the coating. The surface roughness (Ra) of the carbon-doped TiZrN coating was decreased to a maximum of 7.12 nm, and the hydrogen permeability correspondingly decreased by 78% at 573 K.
Role of Fisetin in Selected Malignant Neoplasms in Women
Authors: Markowska Anna , Antoszczak Michał , Kacprzak Karol , Markowska Janina , Huczyński Adam
Published: November 2023

A promising therapeutic window and cost-effectiveness are just two of the potential advantages of using naturally derived drugs. Fisetin (3,3′,4′,7-tetrahydroxyflavone) is a natural flavonoid of the flavonol group, commonly found in fruit and vegetables. In recent years, fisetin has gained wide attention across the scientific community because of its broad spectrum of pharmacological properties, including cytotoxic activity against most abundant cancers. By stimulating or inhibiting selected molecular targets or biochemical processes, fisetin could affect the reduction of metastasis or cancer progression, which indicates its chemotherapeutic or chemopreventive role. In this review, we have summarized the results of studies on the anticancer effects of fisetin on selected female malignancies, both in in vitro and in vivo tests, i.e., breast, cervical, and ovarian cancer, published over the past two decades. Until now, no article dedicated exclusively to the action of fisetin on female malignancies has appeared. This review also describes a growing number of nanodelivery systems designed to improve the bioavailability and solubility of this natural compound. The reported low toxicity and activity of fisetin on cancer cells indicate its valuable potential, but large-scale clinical trials are urgently needed to assess real chemotherapeutic efficacy of this flavonoid.
Dichroism Effects in the Ionization of Polarized Atoms by Short Circularly Polarized Laser Pulses
Authors: Meremianin Alexei V. , Manakov Nikolai L.
Published: November 2023

The dichroism effects, i.e., asymmetries of the ionization probability with respect to the inversion of either the atomic orientation (magnetic dichroism, MD) or the circular polarization degree of the photon beam (circular dichroism, CD), are investigated using the time-dependent perturbation theory (PT). It is shown that the magnitude of these effects depends not only on the polarization states of the atom and laser pulse but also on the intensity and duration of the latter. We find that the CD can also be observed in the ionization of oriented initial bound states, which is impossible in long-pulse ionization. Predictions of our PT analysis are supported by the results obtained by numerical solutions of the time-dependent Schrödinger equation (TDSE) describing the ionization of the excited 2P-states of the hydrogen atom.
Alleviative Effect of Ficus formosana Extract on Peripheral Neuropathy in Ovariectomized Diabetic Mice
Authors: Ko Chih-Yuan , Wu Chung-Hsin , Nguyen Thi Kim Ngan , Chen Li-Wen , Wu James Swi-Bea , Huang Wen-Chung , Shen Szu-Chuan
Published: November 2023

In diabetes mellitus, Ficus formosana has been reported to ameliorate blood sugar levels and inhibit inflammation through its polyphenol and flavonoid contents. However, its effect on diabetic peripheral neuropathy (DPN) remains unknown. This study aimed to investigate the effect of Ficus formosana extract (FFE) on DPN in ovariectomized diabetic mice. Ovariectomized female C57BL/6J mice fed a high-fat diet plus streptozotocin injections to induce type 2 diabetes were orally administered FEE at 20 or 200 mg/kg BW daily, for 6 weeks. To evaluate the pain responses in the paws of the mice, a von Frey filament test and a thermal hyperalgesia test were performed. Additionally, the intraepidermal and sciatic nerve sections were examined, along with an assessment of inflammation- and pain response-related mRNA expression in the paws of the mice. The results showed that the oral administration of both 20 and 200 mg/kg BW FEE significantly alleviated the hypersensitivity of the paw and the abnormal proliferation and rupture of the C fiber, and reduced the mRNA expression of interleukin-1β, interleukin-6, interferon-γ, cyclooxygenase-2, and voltage-gated sodium channel 1.8 in the sciatic nerve of ovariectomized diabetic mice. We propose that FFE ameliorates peripheral neuropathy by suppressing oxidative damage in ovariectomized diabetic mice.
Bio-Monitoring of Metal(loid)s Pollution in Dry Riverbeds Affected by Mining Activity
Authors: Cuevas José , Faz Ángel , Martínez-Martínez Silvia , Gabarrón María , Beltrá Juan , Martínez Jacinto , Acosta José A.
Published: November 2023

The aim of this study was to evaluate the most abundant native plants that could be used as a bio-monitor of metal(loid) concentration in dry riverbeds affected by mining activities. Three plants species and their respective rhizospheric soils were sampled from the El Beal (Piptatherum miliaceum, 15 samples), La Carrasquilla (Foeniculum vulgare, 10 samples), and Ponce (Dittrichia viscosa, 12 samples) dry riverbeds from the mining district of Cartegena-La Unión (SE Spain). There is scanty bibliography of the capacity of these species to be used as bio-monitors in the dry riverbeds. Plants categorized as a bio-monitor were established according to the bioaccumulation factor (BF), mobility ratio (MR), and linear correlations between metal(loid) concentrations in plants tissues (root or stem)-rhizospheric soils. The rhizospheric soils were highly contaminated for As, Cd, Pb, and Zn (Cf ≥ 6), and moderately contaminated for Mn (1 ≤ Cf < 3). Piptatherum miliaceum presented on Cd similar mean concentrations on rhizospheric soil and root, BF = 1.07, with a strong correlation soil–root (r = 0.61, p = 0.02). Therefore, of the three species with the capacity to grow in the area, Piptatherum miliaceum showed characteristics to be considered as a bio-monitor for Cd, with a BF > 1, and a positive–significant correlation between the rhizospheric soil and roots.
Drug Delivery of Gelatin Nanoparticles as a Biodegradable Polymer for the Treatment of Infectious Diseases: Perspectives and Challenges
Authors: Madkhali Osama A.
Published: November 2023

In recent years, there has been a growing interest in the use of gelatin nanoparticles (GNPs) for the treatment of infectious diseases. The inherent properties of these nanoparticles make them attractive options for drug delivery. Their biocompatibility ensures that they can interact with biological systems without causing adverse reactions, while their biodegradability ensures that they can break down harmlessly in the body once their function is performed. Furthermore, their capacity for controlled drug release ensures that therapeutic agents can be delivered over a sustained period, thereby enhancing treatment efficacy. This review examines the current landscape of GNP-based drug delivery, with a specific focus on its potential applications and challenges in the context of infectious diseases. Key challenges include controlling drug release rates, ensuring nanoparticle stability under physiological conditions, scaling up production while maintaining quality, mitigating potential immunogenic reactions, optimizing drug loading efficiency, and tracking the biodistribution and clearance of GNPs in the body. Despite these hurdles, GNPs hold promising potential in the realm of infectious disease treatment. Ongoing research and innovation are essential to overcome these obstacles and completely harness the potential of GNPs in clinical applications.
A Rivest–Shamir–Adleman-Based Robust and Effective Three-Factor User Authentication Protocol for Healthcare Use in Wireless Body Area Networks
Authors: Liu Kaijun , Xu Guosheng , Cao Qiang , Wang Chenyu , Jia Jingjing , Gao Yuan , Xu Guoai
Published: November 2023

In healthcare, wireless body area networks (WBANs) can be used to constantly collect patient body data and assist in real-time medical services for patients from physicians. In such security- and privacy-critical systems, the user authentication mechanism can be fundamentally expected to prevent illegal access and privacy leakage occurrences issued by hacker intrusion. Currently, a significant quantity of new WBAN-oriented authentication protocols have been designed to verify user identity and ensure that body data are accessed only with a session key. However, those newly published protocols still unavoidably affect session key security and user privacy due to the lack of forward secrecy, mutual authentication, user anonymity, etc. To solve this problem, this paper designs a robust user authentication protocol. By checking the integrity of the message sent by the other party, the communication entity verifies the other party’s identity validity. Compared with existing protocols, the presented protocol enhances security and privacy while maintaining the efficiency of computation.
Risk Perception and Sense of Public Health Safety: The Mediating Role of Emotional Perception
Authors: Shi Ruyi , Liu Qiqi , Wu Guangzhu
Published: November 2023

The COVID-19 pandemic has not only caused significant economic, social, and cultural impacts, but it has also significantly influenced the public’s sense of psychological health and safety. Therefore, this study aimed to explain the theoretical logic of risk perception and the sense of public health safety. A conceptual framework of risk perception consisting of four dimensions—emotional perception, information perception, trust perception, and efficacy perception—was constructed. Additionally, the impact of risk perception on the sense of public health safety was empirically explored. By conducting an analysis of a survey of 292 residents in China, we found that risk perception had different impacts on residents’ sense of public health safety. Emotional perception and information perception had significantly negative effects on the sense of public health safety, while the effects of trust perception and efficacy perception were significantly positive. Notably, emotional perception played a partial mediating role in the impact of information perception, trust perception, and efficacy perception on sense of public health safety, respectively. The findings of this study showed that emotional perception is a critical mechanism for improving residents’ sense of public health safety. Some certain guidance measures are provided to reduce public anxiety and fear during pandemics.
Field Evaluation of Cotton Expressing Mpp51Aa2 as a Management Tool for Cotton Fleahoppers, Pseudatomoscelis seriatus (Reuter)
Authors: Arthur Brady P. , Suh Charles P. , McKnight Benjamin M. , Parajulee Megha N. , Yang Fei , Kerns David L.
Published: November 2023

The cotton fleahopper (Pseudatomoscelis seriatus Reuter) is considered a highly economically damaging pest of cotton (Gossypium hirsutum L.) in Texas and Oklahoma. Current control methods rely heavily on the use of foliar-applied chemical insecticides, but considering the cost of insecticides and the critical timeliness of applications, chemical control methods are often not optimized to reduce potential yield losses from this pest. The Bacillus thuringiensis (Bt) Mpp51Aa2 (formerly Cry51Aa2.834_16) protein has proven effective against thrips and plant bugs with piercing and sucking feeding behaviors, but the impact of this toxin on cotton fleahoppers has not been investigated. To evaluate the Mpp51Aa2 trait effectiveness towards the cotton fleahopper, field trials were conducted in 2019, 2020, and 2021, comparing a cotton cultivar containing the Mpp51Aa2 trait to a non-traited isoline cultivar under insecticide-treated and untreated conditions. Populations of cotton fleahopper nymphs and adults were estimated weekly by visually inspecting cotton terminals. Square retention was also assessed during the first week of bloom to provide some insight on how the Bt trait may influence yield. While cotton fleahopper population differences between the traited and non-traited plants were not consistently noted during the pre-bloom squaring period, there was a consistent increase in square retention in cotton expressing Mpp51Aa2 relative to non-traited cotton. Additionally, cotton expressing Mpp51Aa2 offered similar square protection relative to non-traited cotton treated with insecticides for the cotton fleahopper. These findings indicate that the Mpp51Aa2 protein should provide benefits of delayed nymphal growth, population suppression, and increased square retention.
Özel Okullarda Eğitim Veren Öğretmenlerin Duygusal Emek Gösterimlerinin Tükenmişlik Düzeyleri Üzerine Etkisi
Authors: SANDIKÇI Tuğçe , DÜŞÜKCAN Muhammet
Published: November 2023

Bu çalışma ile öğretmenlerin duygusal emek gösterimlerinin tükenmişlik düzeyleri üzerindeki etkisinin ortaya konulması amaçlanmaktadır. Bu alanda yapılan araştırmaların gösterdiği üzere, sergilenen duygularla, gerçekte hissedilen duyguların birbirinden farklı olması yani duygusal uyumsuzluk bulunması durumu çalışanların işlerinden sağladıkları doyum düzeylerinin azalmasına ve buna bağlı olarak stres ve tükenmişlik düzeylerinin artmasına sebep olmaktadır. Çalışmada özel okulda eğitim veren öğretmenlerin duygusal emek gösterimlerinin tükenmişlik düzeyleri üzerine etkisi incelenerek, ortaya çıkan sonuca göre öğretmenlerin iş doyumunu artıracak ve stres düzeylerini minimuma indirecek alternatif yollar sunulabilecektir. Çalışmda, Elazığ ilinde bulunan özel okullarda görev yapmakta olan 211 öğretmenin katıldığı bir anket uygulanmıştır. Araştırmada veri aracı olarak ‘’Kişisel Bilgi Formu’’, ‘’Maslach Tükenmişlik Envanteri’’ ve ‘’Duygusal Emek Ölçeği’’ kullanılmıştır. Duygusal emek ile ilgili veriler Diefendorff ve arkadaşları (2005) tarafından, Tükenmişlik ölçeği verileri Maslach ve Jackson (1982) tarafından geliştirilmiştir. Elde edilen veriler SPSS 22 programında çözümlenmiştir. Verilerin analizlerinde, betimleyici istatistikler, güvenirlik analizi, faktör analizi, korelasyon analizi ve regrasyon analiz yöntemleri kullanılmıştır. Çalışma sonucunda, Öğretmenlerin duygusal emek gösterimlerinin tükenmişlikleri üzerinde etkisi olduğu tespit edilmiştir. Buna göre çalışanların duygusal emek gösterimleri (bağımsız değişken), tükenmişlik düzeylerini (bağımlı değişken) %10.9 oranında etkilemektedir. Diğer bir ifade ile bağımsız değişken bağımlı değişkendeki değişimlerin %10.9’unun kaynağı olduğu sonucuna ulaşılmıştır
Del productor al consumidor: estrategias de comercialización en contexto de incertidumbre
Authors: Ghiglione Franco , Braun Rodolfo
Published: November 2023

Objective: To examine and evaluate the marketing strategies implemented in the Municipal Market of the city of Santa Rosa, located in the province of La Pampa, Argentina. Methodology: A case study with an observational, cross-sectional, and descriptive approach. The study is divided into two main perspectives: Firstly, 18 testimonials from municipal officials, producers, and consumers were collected. Secondly, current prices of 44 products grouped into four categories were compared, taking into account quality characteristics, in relation to the average of 10 retail markets, including greengrocers, supermarkets, and neighborhood stores. Results: It was identified that the different stakeholders involved in this market positively value attributes such as price, quality, and food variety. Additionally, price increases ranging from 5% to 83% were observed in local stores compared to the prices traded in the mentioned municipal market. Conclusion: The analyzed strategies are positively appreciated by both producers and consumers.
Utilization of purple yam skin (Ipomoea batatas L.) in the making of nata de batatas
Authors: Gafar Fahira , Oessoe Yoakhim Y.E. , Lamaega Jolanda Ch.E.
Published: November 2023

Nata de batatas is a product of purple sweet potato peel. The presence of anthocyanin compounds in purple sweet potato skin makes this food very attractive to be processed into nata products that have functional value. The purpose of this research was to determine the yield of nata from purple sweet potato peel made with variations in the percentage of purple sweet potato peel extract and the percentage of coconut water and pellicle thickness, evaluate organoleptic properties including texture, color, aroma, taste, and determine anthocyanin levels. The results showed that the highest nata yield was 70.08%. The thickness of the largest 1.26 cm. The best anthocyanin analysis in nata was 0.47 mg. The organoleptic test showed that the color percentage of purple sweet potato peel extract and the percentage of coconut water were significantly different while the texture, aroma and taste were not significantly different.

Keywords: nata de batatas, purple sweet potato skin, coconut water, anthocyanin
Pengaruh Suhu dan Lama Pengeringan terhadap Karakteristik Kimia dan Sensoris Permen Jelly Pepaya (Carica Papaya L.)
Authors: Pandesolang Novita , Lalujan Lana E. , Oessoe Yoakhim
Published: November 2023

Tujuan dari penelitian ini adalah untuk menganalisa pengaruh suhu dan lama pengeringan terhadap karakteristik komponen kimia permen jelly pepaya serta mengevaluasi tingkat kesukaan permen jelly pepaya yang dikeringkan pada suhu dan lama pengeringan yang berbeda. Penelitian ini menggunakan metode Rancangan Acak Lengkap (RAL) yang terdiri dari 4 perlakuan dan 3 pengulangan dengan suhu dan waktu pengeringan yang berbeda yaitu perlakuan pengeringan menggunakan suhu ruang selama 48 jam, pengeringan dengan suhu 40°C selama 36 jam, pengeringan dengan suhu 50°C selama 24 jam dan pengeringan dengan suhu 60°C selama 8 jam. Data yang diperoleh dianalisis menggunakan metode Analisis of Variance (ANOVA), dan nilai yang menunjukan berpengaruh nyata dilakukan uji lanjut Beda Nyata Terkecil (BNT) dengan taraf 5% untuk mengetahui perbedaan antara setiap perlakuan. Hasil penelitian ini menunjukkan bahwa perbedaan suhu dan waktu pengeringan menghasilkan permen jelly pepaya dengan karakteristik kimia yaitu kadar air (10,49% - 23,73%), sukrosa (13,78% - 16,25%), pH (5,36% - 6,17%). Permen jelly pepaya dengan warna, aroma, rasa, dan tekstur yang paling disukai oleh panelis ada pada pengeringan suhu ruang selama 48 jam.

Kata kunci: permen jelly; papaya; pengeringan; sukrosa.
Konsumsi Kopi Jenis Arabika dan Robusta pada Penderita Asam Urat
Authors: Marisa  , Lestari Rinda
Published: November 2023

Asam urat adalah metabolit terakhir purin, yang merupakan salah satu komponen asam nukleat yang terdapat di inti sel manusia. Banyak faktor yang dapat berpengaruh terhadap kadar asam urat seseorang, seperti genetik, gaya hidup dan aktivitas fisik. Kopi adalah salah satu minuman dunia yang paling populer. Tujuan dari penelitian ini untuk mengetahui Perbedaan Kadar Asam   Urat dalam Darah pada Pria Dewasa Berkebiasaan Minum Kopi Dengan Jenis Robusta dan Arabica. Jenis penelitian yang digunakan bersifat Deskriptif Analitik menggunakan metode Cross-Sectional yang bersifat analitik. Populasi dalam penelitian ini adalah pasien penderita Asam Urat yang berkebiasaan minum kopi. Sampel dalam penelitian ini diambil sebanyak 40 orang data pasien Asam Urat yang diambil secara  acak atau random dari populasi. Berdasarkan hasil penelitian didapatkan hasil ujit 0,178>0,05 didapatkan bahwa tidak terdapat perbedaan kadar asam urat antara jenis kopi robusta dan arabika.

Kata Kunci: Asam urat; kopi.
Pengaruh Substitusi Tepung Ampas Kelapa (Cocos Nucifera L.) Terhadap Serat Pangan, Daya Kembang, Karakteristik Kimia Dan Tingkat Kesukaan Bolu
Authors: Pusungulena Sri O. , Nurali Erny J. N. , Assa Jan R.
Published: November 2023

Bolu merupakan produk makanan selingan yang populer dan banyak diminati oleh semua kalangan, mulai dari anak-anak hingga orang dewasa. Bolu adalah kue dengan adonan kental berbahan dasar tepung terigu, gula, telur, dan lemak. Tujuan dari penelitian ini adalah mengevaluasi serat pangan, daya kembang, karakteristik kimia dan tingkat kesukaan bolu yang di substitusikan tepung ampas kelapa. Penelitian ini mengunakan metode rancangan acak lengkap (RAL) yang terdiri dari 5 perlakuan dan 3 kali pengulangan, dengan formulasi penggunaan tepung ampas kelapa dan tepung terigu pada penelitian ini yaitu pada perlakuan A1 tepung ampas kelapa 0% : tepung terigu 100%. Perlakuan A2 tepung ampas kelapa 5% : tepung terigu 95%. Perlakuan A3 tepung ampas kelapa 10% : tepung terigu 90 %.  Perlakuan A4 tepung ampas kelapa 15% : tepung terigu 85%, dan Perlakuan A5 tepung ampas kelapa 20% : tepung terigu 80 %. Kemudian dilakukan analisis daya kembang, serat pangan, kandungan gizi dan uji organoleptik untuk mengetahui tingkat kesukaan dari panelis. Hasil penelitian menunjukkan bahwa substitusi tepung ampas kelapa pada produk bolu tidak berpengaruh nyata pada tingkat pengembangan bolu dan tingkat kesukaan panelis. Hasil analisis serat pangan total bolu yaitu berkisar antara 11,65%-17,84%, serat larut 3,50%-6,83% dan serat pangan tak larut 4,82%-13,62%. Daya kembang bolu dengan nilai rata-rata 42,33-59,37. Kadar air 21,01% SNI maksimal 40%, kadar abu 0,92% SNI maksimal 3%, kadar lemak 13,22% SNI maksimal 3%, kadar protein 7,33% dan Kadar karbohidrat 41,48%. Pada penelitian ini perlakuan yang paling disukai (berdasarkan pada nilai rata-rata paling tinggi pada atribut aroma dan tekstur karena hasil analisis sidik ragam tidak berpengaruh nyata) sesuai uji organoleptik adalah perlakuan A4 (tepung ampas kelapa 15% : tepung terigu 85%) dengan penilaian warna, rasa, aroma dan teksur

Kata kunci: Bolu; Tepung ampas kelapa; serat pangan; daya kembang; substitusi.
Study of the biological activity of pyrazoline derivatives with fusidic acid and ZnO as an antibacterial and antioxidant
Authors: Muhsn Ali hazam,  , Raheem Jameel Mahesein  , H. N. K. AL-Salman
Published: November 2023

pyrazoline was synthesized as a derivative, then the polymerization of pyrazoline was carried out with fusidic acid and zinc oxide. All the physical properties affecting the construction process, such as Thin-layer chromatography, solubility, the effect of buffer solutions, and temperatures, were studied. Physical diagnostics such as DSC, TGA, and FT-IR were also investigated. The study of the biological activity of the polymer resulting from the interaction of pyrimidine with fusidic acid and zinc oxide, where the study was conducted against three types of bacteria, and the results of the study were compared with the activity of fusidic acid alone once and with zinc oxide alone again as a control. The results showed that the process of polymerization of pyrazoline with fusidic acid and zinc oxide gives more excellent results against bacteria compared to fusidic acid alone and zinc oxide alone.
A Suggested Mechanism to Measure External Audit Quality and Failure
Authors: Shamki Dhiaa , Hussein Muwafaq A.
Published: November 2023

This study reviews measures of external audit quality and failure cases through discussing many studies which present them as cases, definitions, and failure reasons. The differences between both cases of audit, as procedures, are theoretically tested by a set of requirements in a suggested designed mechanism titled Audit Quality and Failure Measurement Mechanism (AQFMM) that based on 10 assumptions and includes 5 stages to measure audit. The conclusions of the study point out that the best way to measure audit is by separating between both cases of audit quality and failure and finding their differences and boundaries by the suggested mechanism.
ANÁLISE FATORIAL EXPLORATÓRIA E CONFIRMATÓRIA DE VARIÁVEIS ANTROPOMÉTRICAS E DE DESEMPENHO FÍSICO DE CRIANÇAS
Authors: Vilela Junior Guanis de Barros , Passos Ricardo Pablo
Published: November 2023

exequibilidade pois existem obstáculos em conseguir autorização de pais, responsáveis, escolas, e portanto as amostras, especialmente no Brasil, são pequenas e talvez não representativas do população infantil do país. É importante um esforço de conscientização para pais, diretores de escolas e professores em relação à importância de facilitar o acesso de pesquisadores a essas crianças. Objetivos: 1) realizar análise fatorial exploratória (AFE) para identificar quais as variáveis antropométricas e de capacidades físicas, são mais relevantes para essa população; 2) realizar análise fatorial confirmatória (AFC) a partir da AFE realizada. Métodos: amostra composta por 184 crianças de ambos os sexos, alunos de duas escolas públicas situadas no interior do estado de São Paulo. Foram obtidas as medidas das dobras tricipital (TR) e escapular (ES), o índice de massa corporal (IMC), o percentual de gordura corporal (%G), a relação cintura quadril (RCQ), o teste de agilidade Shuttle Run e o teste de saltar e alcançar. A pesquisa foi aprovada pelo Comitê de Ética em Pesquisa da instituição e os pais ou responsáveis pelas crianças leram e assinaram o Termo de Consentimento Livre e Esclarecido TCLE. Foi utilizado o software JASP® para realização das análise fatoriais; foi adotada p<0,050 em todos os testes estatísticos. Resultados: na AFE o teste KMO obteve MSA>0,600 na maioria das variáveis; o teste de Bartlett, cujo resultado foi X2=3389,942; gl= 78,000 e p< 0,001. Pelo critério de Kaiser, dois fatores apresentaram autovalores superiores a 1,0 e apenas duas variáveis apresentaram singularidades próximas a 1,0. O fator 1 composto por sete variáveis de natureza antropométrica e o fator 2, composto por 4 variáveis, sendo duas delas associadas a testes de aptidão física. Nos resultados da AFC foram encontradas as covariâncias entre os fatores 1 e 2 com valor estimado de -0,406; erro padrão= 0,100; z= -4,050; p < 0,001; IC(-0,603; -0,210) que evidenciaram uma associação entre ambos.
Heidegger, Death and 'Originary-Ethics'
Authors: Hansali Omar
Published: November 2023

Outside the claim that Antigone’s blood relationship is a primal incentive towards her transgressive act, Heidegger’s readings of Antigone couch an overarching insight, which dovetails with the terrible (deinon) in Introduction to Metaphysics. For Heidegger, the deinon as the ‘terrible’ reconciles the historical role of Antigone with the utmost of risk of death. Antigone is able to preserve the essence of dik? through death’s radical negativity. In a remarkable passage, Heidegger says that the deinon is ‘the terrible in the sense of the overwhelming sway’. Instead of claiming that the deinon is transgression or kinship, and thereby reduce the terrible to an objective experience. I argue that the deinon resides precisely in the relationship between death and dik?. Death’s insurmountable risk is what preserves the deinon between fittingness and unfittingness; between homeliness and unhomeliness. I concur that this confrontation can only occur if Antigone’s impulse is neither her brother nor the gods. Both of these affirmations attenuate the risk of dik? since their essence reifies the inarticulate character of Antigone’s impulse. Antigone’s impulse carries that which cannot be named, or more acutely, that which elopes articulation. Antigone’s act is a consequence of a ‘risk’ that keeps itself more risky, more transgressive, and more terrible. As we ponder Heidegger’s understanding of death, it becomes clear that the ‘more terrible and distant’ is the limit beyond all limits. Death fulfills Antigone’s heroic venture in that her act is a concretion of the inarticulate nature of the deinon. The aim of this essay is to ascertain that neither familiar kinship nor transgression cohere with Heidegger’s claim on Antigone’s individual act. It suggests that dik? is the non-metaphysical risk that allows Antigone to envisage death’s radical negativity as the utmost limit that cannot be extinguished. The conclusion of this study ascertains that death’s radical negativity allows Antigone to perceive the finitude of her historical role as a citizen without naming her individual impulse, chiefly because she realizes that transgression is not a final resolve.
Розвиток та особливості використання електрогідравлічного ефекту для штампування високоточних великогабаритних листових деталей
Authors: Taranenko Mykhailo , Naryzhnyi Olexandr
Published: November 2023

Тараненко М. Є., Нарижний О. Г. Розвиток та особливості використання електрогідравлічного ефекту для штампування високоточних великогабаритних листових деталей

В статті відзначена мала ефективність використання традиційних схем електрогідравлічного штампування при виготовленні великогабаритних листових деталей. Запропоновано використовувати для прототипного виробництва таких деталей багатоелектродні розрядні блоки. Зроблено висновок про їх потенційну ефективність та особливості процесу, що ускладнюють штампування. Визначено причини цих ускладнень: недостатня керованість потоками енергії у просторі та різке падіння параметрів навантаження після декількох сотень ЕГ-розрядів. Задачами дослідження стало обґрунтування можливостей просторового управління навантаженням в межах технологічного простору та підвищення стійкості робочих електродів, що піддаються великим силовим навантаженням та електричній ерозії.

За допомогою математичного моделювання показано, що процес передачі енергії від генератора струму до об’єкту обробки носить струминний характер. Це дає можливість управління потоками енергії у просторі технологічного блоку. На практичних прикладах показано можливість подальшого збільшення ефективності самих процесів формоутворення та експлуатаційних характеристик обладнання. Експериментальним шляхом підтверджено досліджувані результати.

Експериментальні доробки елементів технологічного оснащення електрогідравлічного пресу дозволили збільшити період міжремонтної експлуатації до одного місяця, що є задовільним для дослідницького виробництва.

При більше інтенсивній експлуатації встаткування можна використати варіант оснащення одного преса двома комплектами багатоелектродних розрядних блоків, при якому один блок експлуатується, а другий – ремонтується. При виконанні робіт використовувався метод математичного моделювання, адекватність якого підтверджено раніше, і експериментальний метод.
Writings on Patriotic Theme in Chinese Autobiographical Literature of the Song Dynasty China (960-1279
Authors: Ying Wang
Published: November 2023

After the Yuan Army invaded the Central Plain at the end of the Song Dynasty, the Song Empire was broken. Faced with the atmosphere and historical background of the national crisis, the Song scholar-official class generally set up a moral standard and value system of "taking the world as their own duty", regarded loyalty to the country and the emperor as the most righteous path, and made a political choice to consciously transform their identity from scholar-officials to military generals who would save the country from being battered. At the same time, patriotic climax and expression of personality became an inseparable unity. Take Wen tianxiang for example, their loyalty to the Song emperor and patriotism was highly unified with their personality, it has been widely praised by future generations. The outstanding scholars’ writings made a patriotic literature climax at the end of the Song Dynasty. It not only reflected the profound influence of neo-confucianism on the personality construction of the scholar-officials and literary intelligentsia in the Song Dynasty, but also accorded with the orthodox literary thought in the Late Song Dynasty. In their patriotic writings, their noble national integrity of serving the country with death, coupled with their superb talent and creative skills, endowed their works with the epic temperament of shining through the ages. Therefore, the Song scholar-officials’ patriotic writing made the Song Dynasty a highlight moment of patriotic writing in the history of Chinese literature.
Network Infrastructure Development in Serang District
Authors: Chaidir John , Haerofiatna Haerofiatna
Published: November 2023

This study examines the development of network infrastructure in electronic-based government in Serang District by examining empirically the design of this infrastructure development. The data collection technique used is Library Research on secondary data. Literature study was conducted to obtain secondary data in examining in depth the object of study. Data analysis was carried out using the content analysis approach. The results of the study show that the Office of Communication, Informatics, Encryption and Statistics of Serang Regency must be ready to respond to any technological developments to strengthen the position of the Regional Government of Serang Regency. Based on the results of the study it can be concluded that the Information Technology Network Infrastructure Planning can be a direction, a guide in developing information technology in Serang Regency government agencies. This blueprint serves as a guide for unit/Regional Apparatus/Agency leaders in implementing and making the best use of information technology which will have an impact on increasing productivity and quality of service to the community.
Measurement of Working Time in Telecommuting
Authors: Georgiadou Niki
Published: November 2023

The paper focuses on the special characteristics of working time in the case of telecommuting and in particular, on the problematic of teleworking time measurement. First, it examines two systems for measuring teleworking time, namely based on the quantity of work produced or based on the time the employee is connected to the company’s network. Then, it highlights the need for establishing objective mechanisms for measuring teleworking time. Finally, it analyses the provision of telecommuting outside of formal working hours, which is very common in the digital era and confuses working periods with rest periods. Our conclusions focus firstly on the need for legislative regulation, which will posit and specify the methods of measuring telework time and secondly on the imperative need to safeguard the rights of employees in terms of the protection of privacy and personal data.