bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimasi Kombinasi Asam Sitrat dan Asam Tartrat sebagai Zat Pengasam pada Tablet Effervescent Ekstrak Ubi Jalar Ungu (Ipomoea batatas L)
Authors: Syahrina Dahlia , Noval Noval
Published: October 2021

Purple sweet potato has the content of anthocyanin compounds that are efficacious as antioxidants. To deliver these efficacious compounds, formulations of effervescent tablets are required as antioxidants with a combination of citric acid and tartrate acid to accelerate the solubility of the drug. The research aims to optimize the combination of citric acid and tartrate acid as a sourgent on effervescent tablets of purple sweet potato extract using the simplex lattice design method. The manufacture of tablets using a direct pumping method with effervescent powder evaluation includes flow rate test, silent angle, compressibility, and powder moisture. Evaluation of tablets includes organoleptic tests, uniformity of tablet weight, hardness, fragility, and soluble time of tablets—data analysis using simplex lattice design software design expert version 10. The results of effervescent powder evaluation include a test of flow rate, quiet angle, compressibility, and moisture of powder in each formula that already meets the requirements. The physical evaluation results on the effervescent tablet weight uniformity test on F3, F4, and F5 have met the requirements. The evaluation of tablet hardness F1 and F2 also meet the requirements. The results of the evaluation of fragility and time dissolve tablets have met the requirements of all formulas. The simplex lattice design analysis results obtained F5 as the most optimal formula with a concentration of citric acid 103.25 mg and tartrate acid 44.25 mg. The combination of citric acid and tartaric acid affects the evaluation of hardness, fragility, and time-soluble effervescent tablets of purple sweet potato extract. The optimal concentration based on simplex lattice design analysis was obtained in F5 with a citric acid concentration of 103.25 mg and tartrate acid of 44.25 mg.
Aplikasi Program Pencegahan DBD terhadap Perilaku Masyarakat dalam Pengawasan dan Pemberantasan Jentik Nyamuk Demam Berdarah Dengue dengan Menerapkan Teori Health Belief Model
Authors: Wahyudi Yuyud , Ningrum Lilis Sulistiya
Published: October 2021

Dengue Fever is a disease caused by the dengue virus with acute fever symptoms by entering the human bloodstream through the bite of a mosquito from the genus Aedes. Dengue Hemorrhagic Fever (DHF) has spread widely to all provinces in Indonesia. This disease often appears as an Extraordinary Event (KLB) with relatively high morbidity and mortality. Many dengue incidence rates make the application of the DHF prevention program by applying the theory of the Health Belief Model (HBM) as a prevention effort that can change the behavior of healthy and clean living. This HBM consists of four components: perceived susceptibility, perceived severity, perceived benefits, perceived barriers, and cues to action. Based on the results of the study, it was conducted from 16 November - 12 December 2020. This research used a Quasi-experimental research design with the One Group Pre Post-test design approach with a sample of Ngrancah Hamlet RT 25 RW 8 Senggreng Village residents using a total sampling technique. The analysis technique of this research is using univariate analysis. The results of this study indicate that the health belief model theory indicators in the DHF prevention program are close to a maximum value, namely Perceived Susceptibility with a mean value of 17.30, perceived severity with a mean value of 15.80, perceived benefits of 15.80, perceived barrier 16.70, and cues. To act with a mean value of 17.30. This study concludes that these results are expected to increase awareness for healthy and clean behavior in preventing DHF.
Perbedaan Lama Pelepasan Tali Pusat pada Metode Perawatan Tali Pusat Teknik Terbuka dan Tertutup di PMB “SF” Palangka Raya
Authors: Bingan Eline Charla Sabtina
Published: October 2021

Tetanus neonatorum is a disease in neonates caused by Clostridium Tetani spores that enter through the umbilical cord. Various attempts were made to reduce infection in the umbilical cord, one of which is the method of treatment performed on the umbilical cord. This study aims to determine the differences in the old cord release in cord care with open and closed techniques in PMB SF Palangka Raya City. This research design is a descriptive quantitative analytic method with the approach of the type of research used is "True Experiment" real experimental research using observation sheets. The samples used were babies born in SF PMB with 26 babies; the sampling technique used was the non-probability sampling technique, purposive sampling, while the analysis used was Chi-Square. From the study results, it was found that there was a significant difference in the length of umbilical cord release in the umbilical cord treatment method with open and closed techniques with an Exact Sig. (2-tailed) value of 0.011. So the Exact Sig. Value (2-tailed) 0.011 <0.05, then Ho is rejected. And umbilical cord care with the open method is 19 times more effective at accelerating the release of the umbilical cord than the closed umbilical cord treatment method.
Pemberdayaan Panti Asuhan Berkah Palangka Raya sebagai Basis Usaha Olahan Ikan di Kota Palangka Raya Kalimantan Tengah
Authors: Zubaidah Siti , Norhayani Norhayani , Rahayuningsih Sri Endang Agustina
Published: October 2021

The Berkah Palangka Raya Orphanage is located on Jalan G. Obos Induk, Menteng, Jekan Raya. Students are directed to activities that can become provisions when they graduate from school and enter the community by introducing making processed fish nuggets, meatballs, and catfish sempol. The purpose of the activity is to improve the skills of the orphanage in making processed fish and to train entrepreneurship in processed fish. The action was carried out from August to November 2019. The method of activity was socialization, counseling, training, and fish processing. The questionnaire results before the activity showed that 40-90% of students were familiar with processed fish such as nuggets, sempol, and fish balls, but 90-100% did not know how to process them. After the activity, the questionnaire results showed that the orphanage already knew the ingredients for making and how to prepare nuggets, sempol, and fish balls. However, only 50-60% could correctly explain the stages of making nuggets, sempol, and fish balls. The most popular preparations are nuggets because they make it easy, practical, delicious, while others like fish balls because the taste is not much different from meatballs. As many as 90% of orphanage children are interested in entrepreneurship in the fish processing sector because they can make their own money and have a cooking hobby. It can be concluded that the orphanage children can make nuggets, sempol, and fish balls and give quite good results. Processed fish produced by orphanage children is quite tasty and in demand by consumers.
Pembinaan Desain Produk Amplang Ikan sebagai Alternatif Usaha Rumahan bagi Ibu-Ibu PKK Desa Terantang, Barito Kuala
Authors: Nastiti Rizky , Norbaiti Norbaiti , Akbar Masithah , Goenadhi Lydia
Published: October 2021

Terantang Village is located in Barito Kuala Regency, where the women are members of the PKK, which is where they learn to start a home business. Most PKK members are housewives who have just started small businesses such as spinach chips. This training aimed to provide the participants with a business alternative, from determining and designing products that suit their conditions to training on how to produce these products. Fish amplang was offered as an alternative product, considering that the raw material in the form of fish is easy to obtain and does not require special equipment in its manufacture. This activity is carried out by providing material about product design and practicing making fish amplang taught by an amplang business owner. From the activities carried out, the participants gained new skills regarding the design of fish amplang products. In addition, this training is expected to be a provision for them to develop their businesses. Furthermore, from the evaluation results, it is found that the participants are satisfied with the training carried out, especially since they can learn new skills. They also request that similar training be held periodically.
Pemberdayaan Masyarakat dalam Pemanfaatan Kalakai (Stenochlaena palustris (Burm. F) Bedd.) sebagai Antioksidan Alami pada Kelompok Ibu-Ibu PKK di Kelurahan Palam, Kecamatan Cempaka, Banjarbaru
Authors: Restapaty Ratna , Forestryana Dyera , Ramadhan Hafiz , Saputri Revita , Rahmatullah‬ ‪Satrio Wibowo , Fitriah Rahmayanti
Published: October 2021

Prevention of the spread of Covid-19 is an essential effort when there are still highly favorable rates & deaths. The provision of education to prevent the spread of Covid-19 is always carried out with community awareness-based programs to maintain immunity. Community service by utilizing kalakai as a natural antioxidant becomes one of the alternatives to support the government. Kalakai (Stenochlaena palustris (Burm. F) Bedd.)) is a nail plant that is one of the plants with antioxidants typical of Kalimantan whose history is used as traditional medicine. This potential can be utilized and applied through the empowerment of the community of Palam Village, Cempaka Subdistrict, where many Kalakai plants grow wild. The problems found include lack of information and lack of skills of citizens in food processing based on Kalakai plants, especially in terms of food processing with high antioxidants in the form of counseling to the PKK mothers group Palam Cempaka-Banjarbaru Village. The activity method is the extension of educational provision, namely the theory of antioxidants and the potential of Kalakai, and the direct demonstration/practice of making syrups, teas, and kalakai candy. Residents expect to develop processed food products into UMKM, especially of Palam village, as a business opportunity to improve people's living standards.
Similarities and Differences in the European Entrepreneurial Activities
Authors: Mercedes Barrachina
Published: November 2021

Entrepreneurship is a key activity in the economy as it influences in the economic performance by creating new products, new solutions, new methods, new processes and new jobs. High levels entrepreneurship in economies have a positive impact on productivity and competitiveness. According to data from Eurostat (2018), in 2018 in Europe, 3.3 million jobs were created thanks to the 2.5 million companies that were created. Moreover, in 2018, there were a total of 25.3 million active enterprises employing a total of 131 million people. Some of the most relevant entrepreneurial hotpots in Europe are Estonia, Sweden, Latvia and the Netherlands (World Economic Forum, 2017). The main objective of this work is to identify and compare the different European geographical areas and evaluate the characteristics and variables that promote entrepreneurship from the experts' point of view. The GEM database was utilized to extract data for analysis in this research. The results obtained show differences between the Northern and Southern countries for the two analysis perspectives used.
Hubungan Faktor Sosial Demografi Terhadap Kesiapan Ibu Untuk Memulai Perawatan Preventif Kesehatan Gigi Dan Mulut Anak
Authors: Ilmianti Ilmianti , Pamewa Kurniaty , Pertiwisari Amanah
Published: October 2021

Pendahuluan: Pengetahuan ibu sangat penting dalam mendasari terbentuknya perilaku yang mendukung kebersihan gigi dan mulut anak dan di pengaruhi oleh beberapa faktor sosial demografi, diantaranya : pendidikan, usia, status pekerjaan dan jumlah anak. sampel yang dilibatkan adalah ibu yang memiliki anak usia di bawah 5 tahun Tujuan Penelitian: Untuk mengetahui apakah pendidikan, usia, status pekerjaan dan jumlah anak memiliki hubungan terhadap kesiapan ibu dalam memulai perawatan preventif kesehatan gigi dan mulut anak. Bahan dan Metode: Penelitian ini bersifat observasi analitik menggunakan metode cross-sectional. Populasi adalah ibu yang memiliki anak usia di bawah 5 tahun. Penelitian ini dilakukan untuk melihat tingkat pengetahuan orang tua dan wawasan ibu terkait dalam perawatan preventif kesehatan gigi dan mulut anak Hasil: Penelitian yang dilakukan di kecamatan tallo kelurahan pannampu rt/rw004/001 kota makassar tahun 2019 berdasarkan hasil analisis uji chisquare dimana hubungan usia terhadap kesiapan ibu di peroleh hasil  P-value= 0,008 > ?=0,05 , pendidikan terhadap kesiapan ibu di peroleh hasil P-value=0,004 >?=0,05 , status pekerjaan terhadap kesiapan ibu di peroleh hasil P-value = 0,017 >?= 0,05 , jumlah anak terhadap kesiapan ibu di peroleh hasil P-value = 0,002>?=0,05. Dengan demikian Ha yang di peroleh di terima berarti terdapat hubungan dan Ho tidak ada . Kesimpulan: Ada hubungan faktor sosial demografi terhadap kesiapan ibu untuk memulai perawatan preventif kesehatan gigi dan mulut anak.
Perbedaan Pengetahuan Kesehatan Gigi Mulut Sebelum dan Sesudah Penyuluhan Flipchart dan Permainan Ular Tangga
Authors: Febriany Mila , Pamewa Kurniaty , Arifin Fadil Abdillah , Mattalitti Sitti Fahillah Oemar , Wijaya Sarah Zaitun Hanaanin
Published: October 2021

Latar belakang : Pendidikan kesehatan gigi dan mulut harus diperkenalkan kepada anak sedini mungkin agar mereka dapat mengetahui cara memelihara kesehatan gigi dan mulut secara baik dan benar. Flipchart merupakan salah satu alat bantu pendidikan yang sangat sederhana dan cukup efektif untuk digunakan dalam menyampaikan informasi. Ular tangga merupakan salah satu permainan yang dapat digunakan sebagai media pembelajaran. Tujuan : Untuk mengetahui bagaimana perbandingan efektivitas metode edukasi dengan permainan ular tangga dan flipchart terhadap pengetahuan kesehatan gigi dan mulut pada anak kelas 3, 4 dan 5 di SDN Sambung Jawa Makassar. Bahan dan Metode : Penelitian ini bersifat eksperimental semu menggunakan metode purposive sampling . Jumlah sampel yang di gunakan adalah 124 orang dengan rentang usia anak 7-9 tahun. Uji yang digunakan adalah uji Wilcoxon dan uji Mann- Withney. Hasil : Perbedaan nilai rata-rata pengetahuan kesehatan gigi dan mulut pada media edukasi flipchart  adalah 1,500 dan  media edukasi permainan ular tangga adalah 1,661 dengan p-value 0,143 (p<0,05). Kesimpulan: Media edukasi flipchart dan media edukasi permainan ular memiliki efektivitas yang sama terhadap pengetahuan kesehatan gigi dan mulut.
Thirty Years of Italian-Canadian Writing and the AICW
Authors: Zucchero Jim
Published: November 2021

This essay offers an analysis of the past 30 years of activity in the Italian-Canadian literary community and examines the role of the AICW (Association of Italian-Canadian Writers) in supporting, disseminating and analyzing that literary production. It profiles the work of three important figures (Pivato, D’Alfonso, Di Cicco) and notes their contributions in establishing this literary ground. It also asserts that women have played an essential role, both in their literary contributions, and in organizational capacities (editing anthologies and proceedings, organizing and promoting literary events and conferences). The essay considers practical issues (developments in technology), challenges, and the vital relationship between creative works and literary criticism in this body of writing.
Editorial
Authors: Alsancakli Sacha
Published: October 2021

Editorial
Triglyceride to High Density Lipoprotein Cholesterol Ratio in Acute Myocardial Infarction And Its Relationship with Angiographic Severity
Authors: Hossain Md Sahadat , Das Prabir Kumar , Ahsan Syed Ali , Bhattacharjee Biplob , Awal Anisul , Das Sandipan , Mahmud Iqbal , Dhar Sukanta , Bashiruddin ABK , Bhattacharyya Partha , Bhattacharya Debabrata
Published: October 2021

Background: In acute myocardial infarction (AMI) the extent of the coronary artery lesion is evaluated by coronary angiogram (CAG). Recent evidences suggest that, ratio of triglyceride and high-density lipoprotein cholesterol (TG/HDL-C) could be a non-invasive marker for the prediction of the extent of coronary artery lesion. The aim of this study was to evaluate the association between TG/HDL-C ratio and the extent of coronary artery lesion assessed by coronary CAG among AMI patients. Objective: The aim of this study was to assess relationship between TG to HDL-C ratio and extent of coronary artery lesion in AMI patients.
Materials & Method: This cross-sectional study was carried out in the Department of Cardiology, Chittagong Medical College Hospital in 224 admitted AMI patients. Blood samples were taken within 24 hours of admission following AMI for fasting lipid profile assessment, (total cholesterol (TC), HDL-C, low-density lipoprotein cholesterol (LDL-C) and TG). Each patient was underwent CAG within 2 to 6 weeks of the events and angiographic findings were classified according to presence of significant stenosis, number of vessel involved and Gensini score.
Results: The subjects consisted of 197 males and 27 females with a mean age of 51.24 (±11.22) years. Mean value of TC was 185.74 (±41.96) mg/ dL, TG was 222.17 (±99.05) mg/dL, HDL-C was 38.92 (±5.46) mg/dL, LDL-C was 127.99 (±36.94) mg/dL, TG/HDL-C was 5.91 (±2.99), median Gensini score was 28 (Range:1-146). Analysis of receiver operating characteristic curves showed that only TG/HDLC and TG were useful for detecting high Gensini score (score >42), with the former more area under the curve (AUC: 0.611; 95% CI: 0.531-0.691; p=0.008). The TG/HDL-C was an independent predictive factor (Odds ratio: 2.706; 95% CI: 1.397-5.242; p = 0.003) for the presence of significant coronary artery lesion on CAG. Linear regression analysis revealed that, age and TG/HDL-C ratio significantly predicted Gensini score.
Conclusion: TG and HDL-C ratio was independently associated with extent of coronary artery lesion.
Bangladesh Heart Journal 2021; 36(2): 82-88
Prognostic Value of Electrocardiographic Abnormalities and Troponin-I Elevation in Hospitalized COVID-19 Patients
Authors: Awal Anisul , Al Mamun Kazi Shamim , Karim Mohammed Rezaul , Azad Md Saif Uddin , Ahmed Farid Uddin
Published: October 2021

Background: Corona Virus Disease (COVID -19) patients present mainly with respiratory manifestations and viral pneumonia. The cardiovascular presentation includes early signs of acute myocardial injury. Troponin elevation is a frequent laboratory finding in hospitalized patients with the disease, and may reflect direct vascular injury or nonspecific supply-demand imbalance. In this work, we assessed the correlation between different ranges of Troponin elevation, Electrocardiographic (ECG) abnormalities and mortality.
Methods and materials: It was a prospective observational study, conducted in four tertiary care Private Hospitals of Chattogram City of Bangladesh. The study enrolled 181 consecutive patients admitted to hospital from June 01, 2020 to December 31, 2020 due to Covid-19 disease on the basis of presentation of signs and symptoms severity. Upon admission, routine investigations cTnI and ECG were carried out.
Results: Mean age of the patients was 54.3±7.3 years with 63.5% male. Hypertension was the most common comorbidity followed by diabetes and obesity. 57.1% of the patients had abnormal ECG. Abnormal axis deviation [26 % (left axis deviation 23.9% vs right axis deviation 2.0%)], Poor R wave progression (22.9%), T inversion (14.5%), left ventricular hypertrophy (LVH) (11.4%) followed by ST segment depression (8.3%) were major findings observed in the study population. Presence of LVH (p=0.008), ST segment elevation (p≤0.001), ST segment depression (p≤0.001) and T inversion (p=0.003) showed statistically significant association with Severe COVID-19 disease. 48.2% had raised cTnI level. Thirteen (7.2%) patients expired in hospital. The mortality rate increased with incrementally higher troponin group: 12/18 than mildly elevated troponin 1/63 (p < 0.01). The presence of an abnormal ECG finding resulted in significant in the intermediate Troponin elevation group (0.05-1 ng/ml) but not in the low (<0.05 ng/ml) or high (> 1 ng/ml) Troponin elevation groups. There were statistically significant association between between cTnI level and death; and between ECG findings and death.
Conclusion: Study conclude that Troponin-I level and ECG are a prognostic factor for mortality in hospitalized COVID-19 patients.
Bangladesh Heart Journal 2021; 36(2): 105-112
A Case Report on Chronic Digoxin Toxicity
Authors: Bala Poppy , Reza AQM , Ali M Atahar , Khan Mahmood Hasan , Islam Nighat , Reza Sadeed Araf
Published: October 2021

Digitalis glycosides are among the oldest drugs used in cardiology. Nowadays, due to the limited indications for their use (advanced heart failure, usually concomitant with atrial fibrillation), cases of toxicity induced by this class of drugs are rarely observed. Digoxin produces a positive inotropic and bathmotropic effect on the heart, but has a negative chronotropic and dromotropic effect. Cardiac glycosides have a narrow therapeutic window, so digitalis treatment can easily lead to symptoms of overdose. In patients taking digoxin, the drug therapeutic level should be maintained at 1-2 ng/ml; the toxic effects occur at concentrations > 2.8 ng/ml and are mainly related to disturbances of cardiac function and of the circulatory system, as well as gastrointestinal symptoms and CNS disturbances. Here, a 65-years-old patient who was hospitalized following chronic ingestion with acute renal impairment. In spite of rapidly applied gastric irrigation and administration of activated charcoal, the drug level in the patient’s blood was estimated at 8.5 ng/ml. During her stay on the ward, typical symptoms of severe toxicity were observed: from gastric symptoms (severe nausea, vomiting) to conduction disturbances. Type I, moitz type 1 and 2 AV blocks were detected, as well as some supraventricular extrasystoles. These conduction disorders required the use of temporary endocardial pacing. Due to the unavailability of specific antidotes (antidigitalis antibodies) and lack of efficient methods of extracorporeal elimination of the drug, symptomatic treatment comprising the correction of electrolyte disturbances and heart rate control remains the most effective.
Bangladesh Heart Journal 2021; 36(2): 139-144
Predictors of nurses’ caring practice for critically ill patients in critical technological environments: A cross-sectional survey study
Authors: Li Yinglan , Kongsuwan Waraporn
Published: November 2021

Background: Caring practice for critically ill patients refers to the actions/behaviors/performance of nurses while caring for critically ill adult patients in the intensive care unit (ICU). Although the caring practice is vital in ICUs and complex due to the multitude of availabletechnologies, research on ICU nurses’ caring practice and its predictive factors are lacking.
Objective: This study aimed to explore the level of nurses’ caring practice for critically ill patients in critical technological environments in China and its predictors.
Methods: This was a cross-sectional online survey study with 218 ICU nurses in 29 tertiary hospitals of Guizhou province, China, from 1st to 30th April 2020. Data were collected by using e-questionnaires made in the Questionnaire Star program, including the Demographic Data Questionnaire (DDQ), Practice of Technological Competency as Caring in Nursing Instrument (P-TCCNI), Influence of Technology Questionnaire (ITQ), and Nurses’ Professional Value Scale (NPVS). The questionnaires were content validated by three experts. Cronbach’s alpha coefficient was 0.96 for the P-TCCNI, 0.70 for the ITQ, and 0.95 for the NPVS. Links to the questionnaires were distributed by research assistants to WeChat groups including target participants. Statistical Package for the Social Science (SPSS) program version 26 (IBM Corporation, Armonk, NY, USA) was used for data analysis. Descriptive and inferential statistics were used to analyze the data. Multiple linear regression analysis using stepwise solution analysis was performed to identify unique predictors of nurses’ caring practice.
Results: The level of nurses’ caring practice for critically ill patients was high (mean = 87.30, standard deviation = 13.73). The professional value was a significant predictor of nurses’ caring practice (β = 0.41, p = 0.00).
Conclusion: ICU nurses exhibited a high level of caring practice. Professional value was a significant predictor of ICU nurses’ caring practice. Nursing administrators should understand the current situation of caring practice in critical technological environments and design strategies to maintain and improve ICU nurses’ professional value to increase the level of caring practice.
Las prácticas de retroalimentación reflexiva y sus expresiones de desigualdad en tiempos de pandemia
Authors: Chura-Cutipa Luz M. , Linares-Cutipa Nimia T. , Polo-Pari María A. , Zegarra-Palacios Amelia
Published: October 2021

Este estudio se basó en explicar la diferencia entre las prácticas de retroalimentación reflexiva en tiempos de pandemia, en base a la desigualdad en el acceso a herramientas virtuales de forma sincrónica y asincrónica, sobre la forma de retroalimentación reflexiva que realizan los docentes con nuevas y diferentes estrategias digitales aplicadas para el logro de los aprendizajes. Tuvo como objetivo analizar la retroalimentación desde el punto de vista del docente y su importancia en el desarrollo de las competencias lectoras. La metodología aplicada fue la cualitativa, por medio de un diseño fenomenológico, y se empleó la técnica de entrevista a docentes de nivel primario con una guía que consignaba una serie de preguntas en torno a las categorías del presente estudio. Los resultados evidencian que la retroalimentación es posible mediante la enseñanza sincrónica y asincrónica, las cuales son trabajadas desde el desarrollo grupal de los educandos y desde sus evidencias, que influyen en la mejora de las competencias lectoras. Además, las limitaciones tecnológicas de conectividad y accesibilidad evidencian, durante la pandemia (COVID-19), una desigualdad en la retroalimentación, favoreciendo a los que tuvieron un aprendizaje sincrónico, concluyendo en que se establece una buena relación entre las variables estudiadas y que se obtiene una mejora pese a las adversidades económicas.
Cobertura y frames periodístico de la violencia hacia la mujer en el Perú
Authors: Prieto-Campos Carlos , Navarro-García Linda L.
Published: October 2021

El presente estudio se encuentra en el marco de la investigación aplicada para establecer las coberturas y frames periodísticos de la violencia hacia la mujer en el Perú en los diarios El Comercio, La República y Correo. Para ello, se realizó un registro de datos de periódicos de circulación nacional en el año 2020. El método empleado fue el descriptivo, siguiendo la línea cuantitativa y el diseño fue descriptivo simple. La presentación de los datos se hizo a través de la estadística descriptiva. En la investigación se encontró que en los tres diarios se efectúa la cobertura de la violencia hacia la mujer. Sin embargo, se estableció que en el diario Correo la cobertura es mayor, respecto a El Comercio y La República. El uso del género periodístico informativo fue el más utilizado por los periódicos para sus reportes, mientras que en los frames, el que más resalta fue el de atribución de responsabilidad, y el de menor uso, el de las consecuencias económicas.
Desarrollo y fortalecimiento de competencias emocionales en la educación infantil en Iberoamérica: una revisión sistemática
Authors: Simeón-Aguirre Erika E. , Aguirre-Canales Vilma I. , Simeón-Aguirre Adita M. , Carcausto Wilfredo
Published: October 2021

El objetivo de esta revisión fue proporcionar el estado actual respecto a estudios empíricos sobre el desarrollo y fortalecimiento de competencias emocionales en el ámbito de la educación infantil a nivel de Iberoamérica, los cuales fueron extraídos de revistas indexadas en las bases de datos Scopus, EBSCO, Dialnet y SciELO entre los años 2010 al 2019. El análisis de los artículos revisados incluyen aspectos como: (a) las competencias emocionales en el incremento de las actitudes positivas de los actores educativos, (b) el valor del conocimiento y regulación emocional para el mejor el desenvolvimiento de los estudiantes y el desarrollo profesional del docente y (c) la importancia de los estudios y programas educativos basados en el desarrollo y el fortalecimiento de las competencias emocionales que optimicen la gestión pedagógica y el clima del aula. Los resultados respecto a la cantidad de publicaciones revisadas demuestran un carácter ascendente, donde España es el país con el mayor número de publicaciones sobre el tema. Dentro de la metodología identificada se encontró que la mayoría de las publicaciones fueron estudios cuasiexperimentales y preexperimentales que generaron efectos significativos en las competencias emocionales de estudiantes y/o docentes. En conclusión, según los artículos revisados, el desarrollo y fortalecimiento de las competencias emocionales de los estudiantes y/o docentes de educación infantil fue favorable a través de la aplicación de programas en los países de Iberoamérica, así como otros estudios demostraron el alto grado de relación de dichas competencias con otros aspectos relevantes en la formación del estudiante y en la labor del docente.
Evaluation of Green Elements and Thermal Comfort Condition of Assyafaah Mosque, Singapore
Authors: Abdul Rahman Noor Muhammad , Abdullah Muhammad Syukri Imran , Lim Chin Haw
Published: October 2021

A mosque is a place for worship and religious activities that are traditionally built with a typical design and shape with a dome and minaret as its traditional symbols. The most basic design of a mosque is a simple single-storey rectangular-shaped building with a prayer hall inside it. Design in the past was inﬂuenced by social and cultural aspects. However, regional and climatic differences have led to thermal discomfort and unnecessary energy use if the mosque is not properly designed. Therefore, there is a need to consider comprehensive planning and review for passive design to avoid thermal discomfort and excessive use of energy. Assyafaah Mosque in Singapore is one example that considers sustainable elements in its design. While Singapore is located very near to the hot equatorial line, many passive and green features have been integrated into the design and construction of the mosque, and this made it possible to achieve an acceptable thermal condition according to the adaptive and PMV thermal comfort model. The design maximizes the potential of naturally ventilated design with other passive strategies which allow for both thermal comfort and energy saving. This paper aims to study the impact of natural ventilation and other passive design decisions on the thermal comfort of the Assyafaah mosque in a hot and humid climate.
Automated Classification of Breast Cancer Lesions for Digitised Mammograms via Computer-Aided Diagnosis System
Authors: Suradi Saifullah Harith , Abdullah Kamarul Amin , Isa Nor Ashidi Mat
Published: October 2021

Women with breast cancer have a high risk of death. Digitised mammograms can be used to detect the early stage of breast cancer. However, digitised mammograms suffer low contrast appearances that may lead to misdiagnosis. This paper proposes a Computer-Aided Diagnosis (CAD) system of automated classification of breast cancer lesions using a modified image processing technique of Fuzzy Anisotropic Diffusion Histogram Equalization Contrast Adaptive Limited (FADHECAL) incorporated with Multilevel Otsu Thresholding on digitised mammograms. Four main blocks were used in this CAD system, namely; (i) Pre-processing and Enhancement block; (ii) Segmentation block; (iii) Region of Interests (ROIs) Extraction block; and (iv) Classification block. The CAD system was tested on 30 digitised mammograms retrieved from the Mini-Mammographic Image Analysis Society (MIAS) database with various degrees of severity and background tissues. The proposed CAD system showed a high accuracy of 96.67% for the detection of breast cancer lesions.
Influence of Propanol as Additive with Diesel Jatropha Biodiesel Blend Fuel for Diesel Engine
Authors: Ahmed Abu Saleh , Abdul Rahim Nur Adibah , Rahman Md Rezaur , Osman Mohammad Shahril
Published: October 2021

Fossil fuels are widely recognized as non-renewable energy resources. They play an important role in our daily life because they can be used in various applications such as the production of soap and cosmetics, as an energy source and for transportation. However, the use of these fossil fuels causes negative impacts on humans, animals and the environment. These happen due to the emission of harmful gases into the atmosphere. Not only that, the available fossil fuels are decreasing due to continuous usage by humans. As a result, researchers investigated finding alternative ways to overcome this issue by replacing diesel fuel with biodiesel. Biodiesel is more environmentally friendly relative to diesel fuel. A research study was conducted involving biodiesel. The purpose of this study was to produce Jatropha Biodiesel, as well as evaluate the properties of Jatropha biodiesel and diesel Jatropha biodiesel blended with propanol. The production of Jatropha Biodiesel was done by using two-step transesterification which was an acid-catalyzed transesterification and base-catalyzed transesterification. Different methanol to oil ratios had been used to identify the best ratio to reduce the FFA content in the CJO. 9:1 was the best methanol to oil ratio and then tested with different catalyst weights. It was found that an increase in the weight of catalyst might reduce the amount of biodiesel yield. In addition, this study also investigated and predicted the engine performance and characteristics of diesel Jatropha biodiesel blended with propanol at different blending ratios. The properties of these test fuels were studied. Bomb calorimeter, Fourier Transform Infrared Spectroscopy (FT-IR) analysis and Diesel Engine test were done. Thus, the calorific value and functional group of the test fuels were identified and determined. The calorific value of biodiesel was much higher than conventional diesel due to the existence of oxygen. This could be proven as the analysis of FT-IR also showed a (C=O) bond which reflected the presence of oxygen. The oxygen helped in combustion besides reducing the hydrocarbon released into the air. These findings were then reflected and related to the performance of diesel engines.
Activation of NLRP1 and NLRP3 Inflammasomes in Multiple Sclerosis and Clinically Isolated Syndrome
Authors: TANYEL Tuba , MERCAN Özlem , MISIRLI Cemile , TÜRKOĞLU Recai
Published: November 2021

Objective: Multiple sclerosis (MS) is a chronic, inflammatory and neurodegenerative disease characterized with demyelination and axonal damage in central nervous system (CNS). Inflamasomes, which are important part of this inflammatory process, regulate maturation of proinflammatory cytokines. Infamazom complexes are thought to increase in MS attacks. We investigated role of inflammasome complexes (nod-like receptor protein 1 and 3) in serum and cerebrospinal fluid (CSF) levels for MS development.

Methods: Eighteen clinically isolated syndrome (CIS), 19 relapsing remitting multiple sclerosis (RRMS) and 20 healthy control cases were included in the study. Nod-like receptor protein 1 and 3 (NLRP1, NLRP3), inflammasome complex levels and oligoclonal band (OCB) patterns of all the groups were measured in serum and CSF samples using Enzyme-Linked Immuno Sorbent Assay (ELISA) method.

Results: Although NLRP1 and NLRP3 levels in both RRMS and CIS patients measured in serum and CSF were significantly higher than healthy control group, there was no statistically significant difference between RRMS and CIS patients. On the other hand, the levels of NLRP1 and NLRP3 in CSF were significantly higher in OCB pattern positive patients compared to the OCB pattern negative patients.

Conclusion: In this pilot study, it is shown that NLRP1 and NLRP3 inflammasome complexes increased in CSF samples of MS cases and that this tendency occurred during or maybe before the first MS attack. As a result, it was thought that these complexes may have an effect on the formation of the OCB band.
Determination of Energy and Nutrient Intakes in Pediatric Burned Patients
Authors: AKTAÇ Şule , BAŞOĞLU İzel Aycan , CEBECİ Aybike , OGUZ Esma , ÖMEROĞLU Begümhan
Published: November 2021

Objective: The prevalence of malnutrition defined by nutritional insufficiency is substantially high in children admitted to the burn center. This study aimed to evaluate the energy and nutrient intakes of pediatric burned patients.

Methods: This prospective study was conducted between May 2016 and January 2017, involving 45 (2 to 18 years old) children and their caregivers. Data were collected via three 24 h dietary recall, socio demographic questionnaire, and assessment of clinical characteristics was done in the Hospital Burns Centre. The energy and nutrient intakes of pediatric burned patients were calculated using computer software and compared with the nutritional recommendations. Statistical tests included analyses of t-test, ANOVA, Pearson Correlation test, and χ2 tests.

Results: None of the children reached the requirements for energy and macronutrients. There was a negative correlation between the meeting of requirements and the age (P < 0.05). Oral enteral nutrition increased the meeting energy requirements (P < 0.05). Depending on the presence of a perioperative fasting period, the percentage of children who met the energy and protein requirements was significantly lower (P < 0.05). The burned area did not affect the percentage of children meeting their energy and protein intakes (P > 0.05).

Conclusions: Oral enteral nutrition facilitates the ability of children to reach requirements; however, perioperative fasting periods and age are barriers to ensure adequate energy and nutrient intake in pediatric burned patients. Therefore, individualized nutritional support and education is vital for burned children to meet increased energy and nutrient requirements.
Investigation of Therapeutic Ultrasound Dose on Muscle Phantom: An Experimental Study Investigation of Therapeutic Ultrasound Dose
Authors: GÜN Neslişah , KARABOCE Baki , YURDALAN Ufuk
Published: November 2021

Objective: The study aims to investigate the standardized, traceable dose amounts that will create the desired therapeutic physiological change in the tissue and prevent the risk of tissue damage in the light of metrology principles

Methods: In the study carried out in TÜBİTAK National Metrology Institute Medical Metrology Laboratory, a muscle phantom simulating the acoustic properties of muscle tissue was created and thermocouples were placed in it. Ultrasound at different intensities and durations at 1 MHz frequency was applied to the phantom. The temperature changes measured by the thermocouples were recorded. Each measurement was repeated three times and averaged

Results: 14 minutes application at 1 W/cm2 density, 10 minutes application at 1.5 W/cm2 density, ~7 minutes application at 2 W/cm2 density, and ~4 minutes application at 2.5 W/cm2 density have been achieved for the temperature range needed to produce therapeutic effect.

Conclusions: In order to achieve the therapeutic effect, the ultrasound doses used in the procedure should be checked. Measurements in multi-layer phantoms would be useful in future research.
Study on Mechanism of Structure Angle on Microstructure and Properties of SLM-Fabricated 316L Stainless Steel
Authors: Li Xiaofeng , Yi Denghao , Wu Xiaoyu , Zhang Jinfang , Yang Xiaohui , Zhao Zixuan , Wang Jianhong , Liu Bin , Bai Peikang
Published: November 2021

In this study, seven 316L stainless steel (316L SS) bulks with different angles (0°, 15°, 30°, 45°, 60°, 75°, and 90°) relative to a build substrate were built via selective laser melting (SLM). The influences of different angles on the metallography, microstructure evolution, tensile properties, and corrosion resistance of 316L SS were studied. The 0° sample showed the morphology of corrugated columnar grains, while the 90° sample exhibited equiaxed grains but with a strong <101> texture. The 60° sample had a good strength and plasticity: the tensile strength with 708 MPa, the yield strength with 588 MPa, and the elongation with 54.51%. The dislocation strengthening and grain refinement play a vital role in the mechanical properties for different anisotropy of the SLM-fabricated 316L SS. The 90° sample had greater toughness and corrosion resistance, owing to the higher volume fraction of low-angle grain boundaries and finer grains.
The Effect of Vertical and Oblique Inclinations on Fracture Stability and Reoperation Risks in Femoral-Neck Fractures of Nongeriatric Patient
Authors: Jiang Dajun , Zhan Shi , Hu Hai , Zhu Hongyi , Zhang Changqing , Jia Weitao
Published: November 2021

Background: For nongeriatric patients with femoral neck fractures (FNFs), preoperative evaluation of fracture three-dimensional inclination is essential to identify fracture stability, select appropriate fixation strategies, and improved clinical prognoses. However, there is lack of evaluation system which takes into account both vertical and oblique inclinations. The purpose of this study was to comprehensively investigate the effect of vertical and oblique inclinations on fracture stability and reoperation risks.

Methods: We retrospectively reviewed the medical records of 755 FNFs patients with over 2 years follow-up. The 3-D inclination angle in vertical (α) and oblique plane (β) were measured based on CT images. The optimal threshold for unstable 3-D inclination were identified by seeking the highest Youden Index in predicting reoperation and validated in the biomechanical test. According to the cut-off value proposed in the diagnostic analysis, forty-two bone models were divided into seven groups, and were all fixed with traditional three parallel screws. Interfragmentary motion (IFM) was used for comparison among seven groups. The association between reoperation outcome and 3-D inclination was analysed with a multivariate model.

Results and Conclusion: The overall reoperation rate was 13.2%. Unstable 3-D inclination angles with an optimally determined Youden index (0.39) included vertical (α > 70°) and oblique (50°<α < 70° and β > 20°/β < −20°) types. Biomechanical validation showed these fractures had significantly greater (p < 0.05) interfragmentary motion (1.374–2.387 mm vs. 0.330–0.681 mm). The reoperation rate in 3-D unstable group (32.7%) is significantly (p < 0.001) higher than that in 3-D stable group (7.9%). Multivariate analysis demonstrated that 3-D inclination angle was significantly (OR = 4.699, p < 0.001) associated with reoperation. FNFs with α > 70°; 50°<α < 70° and β > 20°/β < −20° are real unstable types with significantly worse interfragmentary stability and higher reoperation risks. Fracture inclination in vertical and oblique planes is closely related to reoperation outcomes and may be a useful complement to the way FNFs are currently evaluated.
FISH Going Meso-Scale: A Microscopic Search for Chromatin Domains
Authors: Maslova Antonina , Krasikova Alla
Published: November 2021

The intimate relationships between genome structure and function direct efforts toward deciphering three-dimensional chromatin organization within the interphase nuclei at different genomic length scales. For decades, major insights into chromatin structure at the level of large-scale euchromatin and heterochromatin compartments, chromosome territories, and subchromosomal regions resulted from the evolution of light microscopy and fluorescencein situhybridization. Studies of nanoscale nucleosomal chromatin organization benefited from a variety of electron microscopy techniques. Recent breakthroughs in the investigation of mesoscale chromatin structures have emerged from chromatin conformation capture methods (C-methods). Chromatin has been found to form hierarchical domains with high frequency of local interactions from loop domains to topologically associating domains and compartments. During the last decade, advances in super-resolution light microscopy made these levels of chromatin folding amenable for microscopic examination. Here we are reviewing recent developments in FISH-based approaches for detection, quantitative measurements, and validation of contact chromatin domains deduced from C-based data. We specifically focus on the design and application of Oligopaint probes, which marked the latest progress in the imaging of chromatin domains. Vivid examples of chromatin domain FISH-visualization by means of conventional, super-resolution light and electron microscopy in different model organisms are provided.
Clinical and Immunological Effects of p53-Targeting Vaccines
Authors: Zhou Shan , Fan Chunmei , Zeng Zhaoyang , Young Ken H. , Li Yong
Published: November 2021

Immunotherapy, including immune checkpoint blockade and chimeric antigen receptor T cells, is one of the most promising approaches to treat cancer. Vaccines have been effective in preventing cancers like liver cancer and cervical cancer with a viral etiology. Instead of preventing disease, therapeutic cancer vaccines mobilize the immune system to attack existing cancer. p53 is dysregulated in the majority of human cancers and is a highly promising target for cancer vaccines. Over twenty clinical trials have targeted p53 in malignant diseases using vaccines. In this work, we review the progress of vaccinations with p53 or its peptides as the antigens and summarize the clinical and immunological effects of p53-targeting vaccines from clinical trials. The delivery platforms include p53 peptides, viral vectors, and dendritic cells pulsed with short peptides or transduced by p53-encoding viruses. These studies shed light on the feasibility, safety, and clinical benefit of p53 vaccination in select groups of patients, implicating that p53-targeting vaccines warrant further investigations in experimental animals and human studies.
Geranylgeraniol Restores Zoledronic Acid-Induced Efferocytosis Inhibition in Bisphosphonate-Related Osteonecrosis of the Jaw
Authors: Chen Xin , Zhu Weiwen , Xu Rongyao , Shen Xin , Fu Yu , Cheng Jie , Liu Laikui , Jiang Hongbing
Published: November 2021

Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a severe side effect of long-term administration of bisphosphonates such as zoledronic acid (ZA), but its pathogenesis remains unclear. Impairment of the clearance of apoptotic cells (termed “efferocytosis”) by ZA may be associated with the pathogenesis of BRONJ. The aim of this study was to investigate whether ZA might inhibit macrophage efferocytosis and promote osteocytic apoptosis, and the underlying mechanisms responsible for the disturbing balance between clean and generation of osteocytic apoptosis. We found that ZA significantly promoted the apoptosis of osteocyte and pre-osteoblast via BRONJ mouse models and in vitro MC3T3-E1 but also inhibited the efferocytosis of macrophage on apoptotic cells. Moreover, supplement with geranylgeraniol (GGOH), a substrate analog for geranylgeranylation of Rac1, could restore Rac1 homeostasis and rescue macrophage efferocytosis. GGOH partially inhibits MC3T3-E1 apoptosis induced by ZA via downregulation of Rac1/JNK pathway. We also examined the Rac1 distribution and activation conditions in bone marrow-derived macrophages (BMDMs) and MC3T3-E1 under ZA treatment, and we found that ZA impaired Rac1 migration to BMDM membrane, leading to round appearance with less pseudopodia and efferocytosis inhibition. Moreover, ZA simultaneously activated Rac1, causing overexpression of P-JNK and cleaved caspase 3 in MC3T3-E1. Finally, the systemic administration of GGOH decreased the osteocytic apoptosis and improved the bone healing of the extraction sockets in BRONJ mouse models. Taken together, our findings provided a new insight and experimental basis for the application of GGOH in the treatment of BRONJ.