bluuebunny/crossref_metadata_2025 huggingface dataset:
Elovanoids Counteract Inflammatory Signaling, Autophagy, Endoplasmic Reticulum Stress, and Senescence Gene Programming in Human Nasal Epithelial Cells Exposed to Allergens
Authors: Resano Alfredo , Bhattacharjee Surjyadipta , Barajas Miguel , Do Khanh V. , Aguado-Jiménez Roberto , Rodríguez David , Palacios Ricardo , Bazán Nicolás G.
Published: January 2022

To contribute to further understanding the cellular and molecular complexities of inflammatory-immune responses in allergic disorders, we have tested the pro-homeostatic elovanoids (ELV) in human nasal epithelial cells (HNEpC) in culture challenged by several allergens. ELV are novel bioactive lipid mediators synthesized from the omega-3 very-long-chain polyunsaturated fatty acids (VLC-PUFA,n-3). We ask if: (a) several critical signaling events that sustain the integrity of the human nasal epithelium and other organ barriers are perturbed by house dust mites (HDM) and other allergens, and (b) if ELV would participate in beneficially modulating these events. HDM is a prevalent indoor allergen that frequently causes allergic respiratory diseases, including allergic rhinitis and allergic asthma, in HDM-sensitized individuals. Our study used HNEpC as an in vitro model to study the effects of ELV in counteracting HDM sensitization resulting in inflammation, endoplasmic reticulum (ER) stress, autophagy, and senescence. HNEpC were challenged with the following allergy inducers: LPS, poly(I:C), or Dermatophagoides farinae plus Dermatophagoides pteronyssinus extract (HDM) (30 µg/mL), with either phosphate-buffered saline (PBS) (vehicle) or ELVN-34 (500 nM). Results show that ELVN-34 promotes cell viability and reduces cytotoxicity upon HDM sensitization of HNEpC. This lipid mediator remarkably reduces the abundance of pro-inflammatory cytokines and chemokines IL-1β, IL-8, VEGF, IL-6, CXCL1, CCL2, and cell adhesion molecule ICAM1 and restores the levels of the pleiotropic anti-inflammatory IL-10. ELVN-34 also lessens the expression of senescence gene programming as well as of gene transcription engaged in pro-inflammatory responses. Our data also uncovered that HDM triggered the expression of key genes that drive autophagy, unfolded protein response (UPR), and matrix metalloproteinases (MMP). ELVN-34 has been shown to counteract these effects effectively. Together, our data reveal a novel, pro-homeostatic, cell-protective lipid-signaling mechanism in HNEpC as potential therapeutic targets for allergies.
Commemorative Issue in Honor of Professor María Vallet Regí: 20 Years of Silica-Based Mesoporous Materials
Authors: Colilla Montserrat , Izquierdo-Barba Isabel , Rodríguez-Donoso Gloria P. , Otamendi-Vallet Natalia
Published: January 2022

This Special Issue entitled “Commemorative Issue in Honor of Professor María Vallet-Regí: 20 Years of Silica-Based Mesoporous Materials” arises from the initiative of the editorial team of Pharmaceutics to pay homage to Professor Maria Vallet-Regí for her ground-breaking pioneering scientific contribution to the field of silica-based mesoporous materials for biomedical applications [...]
A Narrative Review of Cell-Based Approaches for Cranial Bone Regeneration
Authors: Falguera Uceda Maria I. , Sánchez-Casanova Silvia , Escudero-Duch Clara , Vilaboa Nuria
Published: January 2022

Current cranial repair techniques combine the use of autologous bone grafts and biomaterials. In addition to their association with harvesting morbidity, autografts are often limited by insufficient quantity of bone stock. Biomaterials lead to better outcomes, but their effectiveness is often compromised by the unpredictable lack of integration and structural failure. Bone tissue engineering offers the promising alternative of generating constructs composed of instructive biomaterials including cells or cell-secreted products, which could enhance the outcome of reconstructive treatments. This review focuses on cell-based approaches with potential to regenerate calvarial bone defects, including human studies and preclinical research. Further, we discuss strategies to deliver extracellular matrix, conditioned media and extracellular vesicles derived from cell cultures. Recent advances in 3D printing and bioprinting techniques that appear to be promising for cranial reconstruction are also discussed. Finally, we review cell-based gene therapy approaches, covering both unregulated and regulated gene switches that can create spatiotemporal patterns of transgenic therapeutic molecules. In summary, this review provides an overview of the current developments in cell-based strategies with potential to enhance the surgical armamentarium for regenerating cranial vault defects.
Topical Drug Delivery to the Posterior Segment of the Eye
Authors: Löscher Marina , Seiz Chiara , Hurst José , Schnichels Sven
Published: January 2022

Topical drug delivery to the posterior segment of the eye is a very complex challenge. However, topical delivery is highly desired, to achieve an easy-to-use treatment option for retinal diseases. In this review, we focus on the drug characteristics that are relevant to succeed in this challenge. An overview on the ocular barriers that need to be overcome and some relevant animal models to study ocular pharmacokinetics are given. Furthermore, a summary of substances that were able to reach the posterior segment after eye drop application is provided, as well as an outline of investigated delivery systems to improve ocular drug delivery. Some promising results of substances delivered to the retina suggest that topical treatment of retinal diseases might be possible in the future, which warrants further research.
The AI Carbon Footprint and Responsibilities of AI Scientists
Authors: Tamburrini Guglielmo
Published: January 2022

This article examines ethical implications of the growing AI carbon footprint, focusing on the fair distribution of prospective responsibilities among groups of involved actors. First, major groups of involved actors are identified, including AI scientists, AI industry, and AI infrastructure providers, from datacenters to electrical energy suppliers. Second, responsibilities of AI scientists concerning climate warming mitigation actions are disentangled from responsibilities of other involved actors. Third, to implement these responsibilities nudging interventions are suggested, leveraging on AI competitive games which would prize research combining better system accuracy with greater computational and energy efficiency. Finally, in addition to the AI carbon footprint, it is argued that another ethical issue with a genuinely global dimension is now emerging in the AI ethics agenda. This issue concerns the threats that AI-powered cyberweapons pose to the digital command, control, and communication infrastructure of nuclear weapons systems.
Tensor Dictionary Learning with an Enhanced Sparsity Constraint for Sparse-View Spectral CT Reconstruction
Authors: Li Xuru , Sun Xueqin , Zhang Yanbo , Pan Jinxiao , Chen Ping
Published: January 2022

Spectral computed tomography (CT) can divide collected photons into multi-energy channels and gain multi-channel projections synchronously by using photon-counting detectors. However, reconstructed images usually contain severe noise due to the limited number of photons in the corresponding energy channel. Tensor dictionary learning (TDL)-based methods have achieved better performance, but usually lose image edge information and details, especially from an under-sampling dataset. To address this problem, this paper proposes a method termed TDL with an enhanced sparsity constraint for spectral CT reconstruction. The proposed algorithm inherits the superiority of TDL by exploring the correlation of spectral CT images. Moreover, the method designs a regularization using the L0-norm of the image gradient to constrain images and the difference between images and a prior image in each energy channel simultaneously, further improving the ability to preserve edge information and subtle image details. The split-Bregman algorithm has been applied to address the proposed objective minimization model. Several numerical simulations and realistic preclinical mice are studied to assess the effectiveness of the proposed algorithm. The results demonstrate that the proposed method improves the quality of spectral CT images in terms of noise elimination, edge preservation, and image detail recovery compared to the several existing better methods.
An Overview of Common Infrared Techniques for Detecting CO Intermediates on Metal Surfaces for Hydrocarbon Products
Authors: El-Zohry Ahmed M.
Published: January 2022

Detection of intermediates during the catalytic process by infrared techniques has been widely implemented for many important reactions. For the reduction of CO2 into hydrocarbons on metal surfaces, CO molecule is one of the most important transient species to be followed due to its involvement in several products’ pathways, and its distinct vibrational features. Herein, basic understandings behind these utilized infrared techniques are illustrated aiming for highlighting the potential of each infrared technique and its advantages over the other ones for detecting CO molecules on metal surfaces.
High-Frequency Surface Insulation Strength with Nanoarchitectonics of Disiloxane Modified Polyimide Films
Authors: Xing Zhaoliang , Zhang Chong , Xue Naifan , Li Zhihui , Li Fei , Wan Xiangnan , Guo Shaowei , Hao Jianhong
Published: January 2022

High-frequency power transformers are conducive to the reliable grid connection of distributed energy sources. Polyimide is often used for the coating insulation of high-frequency power transformers. However, creeping discharge will cause insulation failure, therefore, it is necessary to use disiloxane for the purpose of modifying the molecular structure of polyimide. This paper not only introduces 1,3-bis(3-aminopropyl)-1,1,3,3-tetramethyldisiloxane (GAPD) with a molar content of 1%, 2%, and 5% to polyimide, but also tests both the physical and chemical properties of the modified film and the high frequency creeping dielectric strength. The results show that after adding GAPD, the overall functional groups of the material do not change, at the same time the transfer complexation of intermolecular charge and the absorption of ultraviolet light increase. There is no phase separation of the material and the structure is more regular and ordered, moreover the crystallinity increases. The overall dielectric constant and the dielectric loss tangent value show different trends, which means that the former value increases, while the latter value decreases. In addition, the resistivity of the surface and the volume increase, which is the same as the glass transition temperature. The mechanical properties are excellent, and the strength of bulk breakdown is mounting. The insulation strength of the high frequency creeping surface has been improved, which will increase with larger contents of GAPD. Among them, the relative change of the creeping flashover voltage is not obvious, and the creeping discharge life of G5 is 4.77 times that of G0. Further analysis shows that the silicon-oxygen chain links of the modified film forms a uniformly dispersed Si-O-Si network in the matrix through chemical bonds and charge transfer complexation. Once the outer matrix is destroyed, it will produce dispersed flocculent inorganic particles which have the role of protecting the inner material and improving the performance of the material. Combined with the ultraviolet light energy absorption, the increase of deep traps, the reduction of dielectric loss, and the improvement of thermodynamic performance, can better improve the high-frequency creeping insulation strength of polyimide film and its potential application value.
A Novel Generation of Polysulfone/Crown Ether-Functionalized Reduced Graphene Oxide Membranes with Potential Applications in Hemodialysis
Authors: Pandele Andreea Madalina , Oprea Madalina , Dutu Andreea Aura , Miculescu Florin , Voicu Stefan Ioan
Published: January 2022

Heavy metal poisoning is a rare health condition caused by the accumulation of toxic metal ions in the soft tissues of the human body that can be life threatening if left untreated. In the case of severe intoxications, hemodialysis is the most effective method for a rapid clearance of the metal ions from the bloodstream, therefore, the development of hemodialysis membranes with superior metal ions retention ability is of great research interest. In the present study, synthetic polysulfone membranes were modified with reduced graphene oxide functionalized with crown ether, an organic compound with high metal ions complexation capacity. The physico-chemical characteristics of the composite membranes were determined by FT-IR, Raman, XPS and SEM analysis while their efficiency in retaining metal ions was evaluated via ICP-MS analysis. The obtained results showed that the thermal stability of reduced graphene oxide was improved after functionalization with crown ether and that the presence of the carbonaceous filler influenced the membranes morphology in terms of pore dimensions and membrane thickness. Moreover, the ability of Cu2+ ions retention from synthetic feed solution was up to three times higher in the case of the composite membranes compared to the neat ones.
Poly(vinylalcohol) (PVA) Assisted Sol-Gel Fabrication of Porous Carbon Network-Na3V2(PO4)3 (NVP) Composites Cathode for Enhanced Kinetics in Sodium Ion Batteries
Authors: Yang Junghoon , Choi Duyoung , Kim Kwang-Seok , Kim Dae Up , Kim Jungpil
Published: January 2022

Na3V2(PO4)3 is regarded as one of the promising cathode materials for next-generation sodium ion batteries, but its undesirable electrochemical performances due to inherently low electrical conductivity have limited its direct use for applications. Motivated by the limit, this study employed a porous carbon network to obtain a porous carbon network–Na3V2(PO4)3 composite by using poly(vinylalcohol) assised sol-gel method. Compared with the typical carbon-coating approach, the formation of a porous carbon network ensured short ion diffusion distances, percolating electrolytes by distributing nanosized Na3V2(PO4)3 particles in the porous carbon network and suppressing the particle aggregation. As a result, the porous carbon network–Na3V2(PO4)3 composite exhibited improved electrochemical performances, i.e., a higher specific discharge capacity (~110 mAh g−1 at 0.1 C), outstanding kinetic properties (~68 mAh g−1 at 50 C), and stable cyclic stability (capacity retention of 99% over 100 cycles at 1 C).
The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors
Authors: Sizova Svetlana , Shakurov Ruslan , Mitko Tatiana , Shirshikov Fedor , Solovyeva Daria , Konopsky Valery , Alieva Elena , Klinov Dmitry , Bespyatykh Julia , Basmanov Dmitry
Published: January 2022

Here, we propose and study several types of quartz surface coatings designed for the high-performance sorption of biomolecules and their subsequent detection by a photonic crystal surface mode (PC SM) biosensor. The deposition and sorption of biomolecules are revealed by analyzing changes in the propagation parameters of optical modes on the surface of a photonic crystal (PC). The method makes it possible to measure molecular and cellular affinity interactions in real time by independently recording the values of the angle of total internal reflection and the angle of excitation of the surface wave on the surface of the PC. A series of dextrans with various anchor groups (aldehyde, carboxy, epoxy) suitable for binding with bioligands have been studied. We have carried out comparative experiments with dextrans with other molecular weights. The results confirmed that dextran with a Mw of 500 kDa and anchor epoxy groups have a promising potential as a matrix for the detection of proteins in optical biosensors. The proposed approach would make it possible to enhance the sensitivity of the PC SM biosensor and also permit studying the binding process of low molecular weight molecules in real time.
Thermal Pyrolysis of Polystyrene Aided by a Nitroxide End-Functionality Improved Process and Modeling of the Full Molecular Weight Distribution
Authors: Monroy-Alonso Antonio , Ordaz-Quintero Almendra , Ramirez Jorge C. , Saldívar-Guerra Enrique
Published: January 2022

A significantly improved thermal pyrolysis process for polystyrene (PS) is reported and mathematically modeled, including the description of the time evolution of the full molecular weight distribution of the polymer during its degradation by direct integration of the balance equations without simplifications. The process improves the styrene yield from 28–39%, reached in our previous report, to 58–75% by optimizing the heating ramp during the initial stage of the pyrolysis process. The process was tested at 390 and 420 °C on samples of conventional PS synthesized via free-radical polymerization (FRP) and PS with a nitroxide end-functionality synthesized via nitroxide mediated polymerization (NMP) with three levels of the nitroxide to initiator (N/I) molar ratio: 0.9, 1.1 and 1.3. The NMP-PS produced with N/I = 1.3 generates the highest styrene yield (75.2 ± 6.7%) with respect to the best FRP-PS yield (64.9 ± 1.2%), confirming the trends observed in our previous study. The mathematical model corrects some problems of a previous model that was based on assumptions that led to significant errors in the predictions; this is achieved by solving the full molecular weight distribution (MWD) without assumptions. The model provides further insight into the initial stages of the pyrolysis process which seem to be crucial to determine the chemical paths of the process and the styrene yield, as well as the influences of the initial heating ramp used and the presence of a nitroxide end-functionality in the polymer.
Protection of Urban Art Painting: A Laboratory Study
Authors: Macchia Andrea , Capriotti Sara , Rivaroli Laura , Ruffolo Silvestro Antonio , La Russa Mauro Francesco
Published: January 2022

Urban art is a form of artistic visual expression and communication that is created in the street and generally in the public dimension of urban spaces. Often these kinds of artworks are in outdoor environments, and they usually suffer from atmospheric weathering and anthropic vandalism. Recently, several strategies have been used to limit or remove the effects of such vandalism. Currently, the use of quartz paints is growing among artists; such paints after setting are more porous and rough on the surface with respect to regular paints. The aim of the study is to assess the performance of anti-graffiti coatings on quartz artworks paints. Two anti-graffiti products were chosen, and their behaviors were assessed in the laboratory by means of contact angle measurement, water capillary test, colorimetric analysis, and optical and electron microscopy. Results showed good water repellence efficacy of the tested products, demonstrating that they are suitable for the protection of urban art, but at least two applications on the surface are needed to achieve good performance.
Cellulose-Derived Nanostructures as Sustainable Biomass for Supercapacitors: A Review
Authors: Ji Seong Min , Kumar Anuj
Published: January 2022

Sustainable biomass has attracted a great attention in developing green renewable energy storage devices (e.g., supercapacitors) with low-cost, flexible and lightweight characteristics. Therefore, cellulose has been considered as a suitable candidate to meet the requirements of sustainable energy storage devices due to their most abundant nature, renewability, hydrophilicity, and biodegradability. Particularly, cellulose-derived nanostructures (CNS) are more promising due to their low-density, high surface area, high aspect ratio, and excellent mechanical properties. Recently, various research activities based on CNS and/or various conductive materials have been performed for supercapacitors. In addition, CNS-derived carbon nanofibers prepared by carbonization have also drawn considerable scientific interest because of their high conductivity and rational electrochemical properties. Therefore, CNS or carbonized-CNS based functional materials provide ample opportunities in structure and design engineering approaches for sustainable energy storage devices. In this review, we first provide the introduction and then discuss the fundamentals and technologies of supercapacitors and utilized materials (including cellulose). Next, the efficacy of CNS or carbonized-CNS based materials is discussed. Further, various types of CNS are described and compared. Then, the efficacy of these CNS or carbonized-CNS based materials in developing sustainable energy storage devices is highlighted. Finally, the conclusion and future perspectives are briefly conferred.
Photo-Embossed Surface Relief Structures with Improved Aspect Ratios and Their Applications in Liquid Crystal Devices
Authors: Yang Xiulan , Gu Minzhao , Wei Qunmei , Zhang Yang , Wu Sihan , Wu Qin , Hu Xiaowen , Zhao Wei , Zhou Guofu
Published: January 2022

Photo-embossing has been developed as a convenient and economical method for creating complex surface relief structures in polymer films. The pursuit for large aspect ratios of the photo-embossed structures has never stopped. Here, we demonstrate a simple strategy to obtain improved aspect ratios by adding a quick solvent developing step into the photo-embossing process. A good solvent for the monomer is used to remove unreacted monomers from the unexposed region, resulting in deepened valleys of the surface reliefs. In a polymer film as thin as 2.5 µm, the height of the surface reliefs can be increased by a factor of three to around 1.0 µm. This strategy is also shown to be compatible with other methods used to improve the aspect ratios of the photo-embossed structures. Lastly, we employ these surface relief structures in the fabrication of liquid crystal (LC) devices and investigate their performances for visible light regulation.
Influence of Phosphorylation and Acetylation on Structural, Physicochemical and Functional Properties of Chestnut Starch
Authors: Liu Chang , Yan Hejing , Liu Suwen , Chang Xuedong
Published: January 2022

Chestnut is popular worldwide for its unique flavor, high eating quality and nutrition. Here, we evaluated the influence of phosphorylation and acetylation on the structural, physicochemical and functional properties of chestnut starch. Scanning electron micrographs showed the agglomeration of starch granules and the appearance of numerous dents on the starch granule surface under phosphorylation and acetylation. X-ray diffractograms confirmed that the modification treatments did not affect the C-type crystal pattern, but reduced the relative crystallinity of the chestnut starch, particularly phosphorylation. Moreover, modification improved the paste transparency of the starch. Differential scanning calorimeter analysis revealed that the gelatinization temperature and enthalpy of the starch decreased with the increasing substitution degree, particularly in phosphorylated starch. The Rapid Visco Analyser analysis demonstrated that phosphorylation could greatly improve the pasting properties of chestnut starch. In addition, phosphorylated and acetylated starch had a smaller amount of slowly digested starch and a larger amount of resistant starch relative to native chestnut starch. In conclusion, the functional and physicochemical properties of chestnut starch can be significantly improved through phosphorylation and acetylation, demonstrating its great application potential as a food additive.
A Review on Antimicrobial Packaging from Biodegradable Polymer Composites
Authors: Kamarudin Siti Hasnah , Rayung Marwah , Abu Falah , Ahmad So’bah , Fadil Fatirah , Karim Azrena Abdul , Norizan Mohd Nurazzi , Sarifuddin Norshahida , Mat Desa Mohd Shaiful Zaidi , Mohd Basri Mohd Salahuddin , Samsudin Hayati , Abdullah Luqman Chuah
Published: January 2022

The development of antimicrobial packaging has been growing rapidly due to an increase in awareness and demands for sustainable active packaging that could preserve the quality and prolong the shelf life of foods and products. The addition of highly efficient antibacterial nanoparticles, antifungals, and antioxidants to biodegradable and environmentally friendly green polymers has become a significant advancement trend for the packaging evolution. Impregnation of antimicrobial agents into the packaging film is essential for impeding or destroying the pathogenic microorganisms causing food illness and deterioration. Higher safety and quality as well as an extended shelf life of sustainable active packaging desired by the industry are further enhanced by applying the different types of antimicrobial packaging systems. Antimicrobial packaging not only can offer a wide range of advantages, but also preserves the environment through usage of renewable and biodegradable polymers instead of common synthetic polymers, thus reducing plastic pollution generated by humankind. This review intended to provide a summary of current trends and applications of antimicrobial, biodegradable films in the packaging industry as well as the innovation of nanotechnology to increase efficiency of novel, bio-based packaging systems.
Crystallization Behavior and Electrical Properties of Nanoparticle-Reinforced Poly(lactic Acid)-Based Films
Authors: Li Mei-Xian , Ren Yu , Lee Dasom , Choi Sung-Woong
Published: January 2022

Graphene oxide (GO) and multiwalled carbon nanotubes with silver particles (MWNT-Ag) of different concentrations were used as nanofillers to prepare poly(lactic acid) (PLA) nanoparticle films through the solvent casting method. In this study, the effects of nanoparticles on the crystallization behavior, relationships between the dispersion and electrical properties, and hydrolytic degradation behaviors were investigated for the PLA/MWNT-Ag and PLA/rGO films. Differential scanning calorimetry was used to evaluate the crystallization behaviors of the PLA/MWNT-Ag and PLA/reduced GO (rGO) films. Electron probe microanalysis was performed to characterize the dispersion of MWNT-Ag, and X-ray diffraction and Raman spectroscopy were used to determine the degree of dispersion of rGO in the PLA matrix. The results showed that nanoparticles enhanced the crystallization kinetics of PLA as well as the hydrolytic degradation rate. From the measurement of electrical properties, the electrical conductivity of PLA/MWNT-Ag 1.0 wt% was much higher than that of the pure PLA and PLA/rGO films, showing that MANT and Ag nanoparticles contribute greatly to enhancing the electrical conductivity of the PLA/MWNT-Ag films.
Adaptive Conformal Cooling of Injection Molds Using Additively Manufactured TPMS Structures
Authors: Oh Seo-Hyeon , Ha Jong-Wook , Park Keun
Published: January 2022

In injection molding, cooling channels are usually manufactured with a straight shape, and thus have low cooling efficiency for a curved mold. Recently, additive manufacturing (AM) was used to fabricate conformal cooling channels that could maintain a consistent distance from the curved surface of the mold. Because this conformal cooling channel was designed to obtain a uniform temperature on the mold surface, it could not efficiently cool locally heated regions (hot spots). This study developed an adaptive conformal cooling method that supports localized-yet-uniform cooling for the heated region by employing micro-cellular cooling structures instead of the typical cooling channels. An injection molding simulation was conducted to predict the locally heated region, and a mold core was designed to include a triply periodic minimal surface (TPMS) structure near the heated region. Two biomimetic TPMS structures, Schwarz-diamond and gyroid structures, were designed and fabricated using a digital light processing (DLP)-type polymer AM process. Various design parameters of the TPMS structures, the TPMS shapes and base coordinates, were investigated in terms of the conformal cooling performance. The mold core with the best TPMS design was fabricated using a powder-bed fusion (PBF)-type metal AM process, and injection molding experiments were conducted using the additively manufactured mold core. The developed mold with TPMS cooling achieved a 15 s cooling time to satisfy the dimensional tolerance, which corresponds to a 40% reduction in comparison with that of the conventional cooling (25 s).
The Process of Pasting and Gelling Modified Potato Starch with LF-NMR
Authors: Walkowiak Katarzyna , Przybył Krzysztof , Baranowska Hanna Maria , Koszela Krzysztof , Masewicz Łukasz , Piątek Michał
Published: January 2022

Currently, society expects convenience food, which is healthy, safe, and easy to prepare and eat in all conditions. On account of the increasing popularity of modified potato starch in food industry and its increasing scope of use, this study focused on improving the physical modification of native starch with temperature changes. As a result, it was found that the suggested method of starch modification with the use of microwave power of 150 W/h had an impact on the change in starch granules. The LF-NMR method determined the whole range of temperatures in which the creation of a starch polymer network occurs. Therefore, the applied LF-NMR technique is a highly promising, noninvasive physical method, which allows obtaining a better-quality structure of potato starch gels.
Fabrication of Polyvinylidene Difluoride Membrane with Enhanced Pore and Filtration Properties by Using Tannic Acid as an Additive
Authors: Mulyati Sri , Aprilia Sri , Muchtar Syawaliah , Syamsuddin Yanna , Rosnelly Cut Meurah , Bilad Muhammad Roil , Samsuri Shafirah , Ismail Noor Maizura
Published: January 2022

Potential use of tannic acid (TA) as an additive for fabrication of polyvinylidene difluoride (PVDF) membrane was investigated. The TA was introduced by blending into the dope solution with varying concentrations of 0, 1, 1.5, and 2 wt%. The prepared membranes were characterized and evaluated for filtration of humic acid (HA) solution. The stability of the membrane under harsh treatment was also evaluated by one-week exposure to acid and alkaline conditions. The results show that TA loadings enhanced the resulting membrane properties. It increased the bulk porosity, water uptake, and hydrophilicity, which translated into improved clean water flux from 15.4 L/m2.h for the pristine PVDF membrane up to 3.3× for the TA-modified membranes with the 2 wt% TA loading. The flux recovery ratio (FRR) of the TA-modified membranes (FRRs = 78–83%) was higher than the pristine one (FRR = 58.54%), with suitable chemical stability too. The improved antifouling property for the TA-modified membranes was attributed to their enhanced hydrophilicity thanks to improved morphology and residual TA in the membrane matric.
Reusable and pH-Stable Luminescent Sensors for Highly Selective Detection of Phosphate
Authors: Kim Do Yeob , Kim Dong Gyu , Jeong Bongjin , Kim Young Il , Heo Jungseok , Lee Hyung-Kun
Published: January 2022

Phosphate sensors have been actively studied owing to their importance in water environment monitoring because phosphate is one of the nutrients that result in algal blooms. As with other nutrients, seamless monitoring of phosphate is important for understanding and evaluating eutrophication. However, field-deployable phosphate sensors have not been well developed yet due to the chemical characteristics of phosphate. In this paper, we report on a luminescent coordination polymer particle (CPP) that can respond selectively and sensitively to a phosphate ion against other ions in an aquatic ecosystem. The CPPs with an average size of 88.1 ± 12.2 nm are embedded into membranes for reusable purpose. Due to the specific binding of phosphates to europium ions, the luminescence quenching behavior of CPPs embedded into membranes shows a linear relationship with phosphate concentrations (3–500 μM) and detection limit of 1.52 μM. Consistent luminescence signals were also observed during repeated measurements in the pH range of 3–10. Moreover, the practical application was confirmed by sensing phosphate in actual environmental samples such as tap water and lake water.
Probing the Nanoscale Heterogeneous Mixing in a High-Performance Polymer Blend
Authors: Fellows Alexander Paul , Puhan Debashis , Wong Janet S. S. , Casford Michael T. L. , Davies Paul B.
Published: January 2022

The blend of polyetheretherketone (PEEK) and polybenzimidazole (PBI) produces a high-performance blend (PPB) that is a potential replacement material in several industries due to its high temperature stability and desirable tribological properties. Understanding the nanoscale structure and interface of the two domains of the blend is critical for elucidating the origin of these desirable properties. Whilst achieving the physical characterisation of the domain structures is relatively uncomplicated, the elucidation of structures at the interface presents a significant experimental challenge. In this work, we combine atomic force microscopy (AFM) with an IR laser (AFM-IR) and thermal cantilever probes (nanoTA) to gain insights into the chemical heterogeneity and extent of mixing within the blend structure for the first time. The AFM-IR and nanoTA measurements show that domains in the blend are compositionally different from those of the pure PEEK and PBI polymers, with significant variations observed in a transition region several microns wide in proximity to domain boundary. This strongly points to physical mixing of the two components on a molecular scale at the interface. The versatility intrinsic to the combined methodology employed in this work provides nano- and microscale chemical information that can be used to understand the link between properties of different length scales across a wide range of materials.
Fouling Prevention in Polymeric Membranes by Radiation Induced Graft Copolymerization
Authors: Zainol Abidin Muhammad Nidzhom , Nasef Mohamed Mahmoud , Matsuura Takeshi
Published: January 2022

The application of membrane processes in various fields has now undergone accelerated developments, despite the presence of some hurdles impacting the process efficiency. Fouling is arguably the main hindrance for a wider implementation of polymeric membranes, particularly in pressure-driven membrane processes, causing higher costs of energy, operation, and maintenance. Radiation induced graft copolymerization (RIGC) is a powerful versatile technique for covalently imparting selected chemical functionalities to membranes’ surfaces, providing a potential solution to fouling problems. This article aims to systematically review the progress in modifications of polymeric membranes by RIGC of polar monomers onto membranes using various low- and high-energy radiation sources (UV, plasma, γ-rays, and electron beam) for fouling prevention. The feasibility of the modification method with respect to physico-chemical and antifouling properties of the membrane is discussed. Furthermore, the major challenges to the modified membranes in terms of sustainability are outlined and the future research directions are also highlighted. It is expected that this review would attract the attention of membrane developers, users, researchers, and scientists to appreciate the merits of using RIGC for modifying polymeric membranes to mitigate the fouling issue, increase membrane lifespan, and enhance the membrane system efficiency.
A Mini-Review of Strategies for Quantifying Anthropogenic Activities in Microplastic Studies in Aquatic Environments
Authors: Lin Chun-Ting , Chiu Ming-Chih , Kuo Mei-Hwa
Published: January 2022

Microplastic pollution is no longer neglected worldwide, as recent studies have unveiled its potential harm to ecosystems and, even worse, to human health. Numerous studies have documented the ubiquity of microplastics, reflecting the necessity of formulating corresponding policies to mitigate the accumulation of microplastics in natural environments. Although anthropogenic activities are generally acknowledged as the primary source of microplastics, a robust approach to identify sources of microplastics is needed to provide scientific suggestions for practical policymaking. This review elucidates recent microplastic studies on various approaches for quantifying or reflecting the degree to which anthropogenic activities contribute to microplastic pollution. Population density (i.e., often used to quantify anthropogenic activities) was not always significantly correlated with microplastic abundance. Furthermore, this review argues that considering potential sources near sample sites as characteristics that may serve to predict the spatial distribution of microplastics in aquatic environments is equivocal. In this vein, a watershed-scale measure that uses land-cover datasets to calculate different percentages of land use in the watershed margins delineated by using Geographic Information System (GIS) software is discussed and suggested. Progress in strategies for quantifying anthropogenic activities is important for guiding future microplastic research and developing effective management policies to prevent microplastic contamination in aquatic ecosystems.
Sustainable Rigid Polyurethane Foam from Wasted Palm Oil and Water Hyacinth Fiber Composite—A Green Sound-Absorbing Material
Authors: Sukhawipat Nathapong , Saengdee Laksana , Pasetto Pamela , Junthip Jatupol , Martwong Ekkachai
Published: January 2022

A novel rigid sound-absorbing material made from used palm oil-based polyurethane foam (PUF) and water hyacinth fiber (WHF) composite was developed in this research. The NCO index was set at 100, while the WHF content was set at 1%wt with mesh sizes ranging from 80 to 20. The mechanical properties, the morphology, the flammability, and the sound absorption coefficient (SAC) of the PUF composite were all investigated. When the WHF size was reduced from 80 to 20, the compression strength of the PUF increased from 0.33 to 0.47 N/mm2. Furthermore, the use of small fiber size resulted in a smaller pore size of the PUF composite and improved the sound absorption and flammability. A feasible sound-absorbing material was a PUF composite with a WHF mesh size of 80 and an SAC value of 0.92. As a result, PUF derived from both water hyacinth and used palm oil could be a promising green alternative material for sound-absorbing applications.
Designing Phenyl Porous Organic Polymers with High-Efficiency Tetracycline Adsorption Capacity and Wide pH Adaptability
Authors: Nie Wenjie , Liu Jiao , Bai Xue , Xing Zefeng , Gao Ying
Published: January 2022

Adsorption is an effective method to remove tetracycline (TC) from water, and developing efficient and environment-friendly adsorbents is an interesting topic. Herein, a series of novel phenyl porous organic polymers (P-POPs), synthesized by one-pot polymerization of different ratios of biphenyl and triphenylbenzene under AlCl3 catalysis in CH2Cl2, was studied as a highly efficient adsorbent to removal of TC in water. Notably, the obtained POPs possessed abundant phenyl-containing functional groups, large specific surface area (1098 m2/g) with abundant microporous structure, high pore volume (0.579 cm3/g), favoring the removal of TC molecules. The maximum adsorption capacity (fitted by the Sips model) could achieve 581 mg/g, and the adsorption equilibrium is completed quickly within 1 h while obtaining excellent removal efficiency (98%). The TC adsorption process obeyed pseudo-second-order kinetics and fitted the Sips adsorption model well. Moreover, the adsorption of POPs to TC exhibited a wide range of pH (2–10) adaptability and outstanding reusability, which could be reused at least 5 times without significant changes in structure and efficiency. These results lay a theoretical foundation for the application of porous organic polymer adsorbents in antibiotic wastewater treatment.
Odor and Constituent Odorants of HDPE–Lignin Blends of Different Lignin Origin
Authors: Lok Bianca , Mueller Gunnar , Ganster Johannes , Erdmann Jens , Buettner Andrea , Denk Philipp
Published: January 2022

The still-rising global demand for plastics warrants the substitution of non-renewable mineral oil-based resources with natural products as a decisive step towards sustainability. Lignin is one of the most abundant natural polymers and represents an ideal but hitherto highly underutilized raw material to replace petroleum-based resources. In particular, the use of lignin composites, especially polyolefin–lignin blends, is currently on the rise. In addition to specific mechanical property requirements, a challenge of implementing these alternative polymers is their heavy odor load. This is especially relevant for lignin, which exhibits an intrinsic odor that limits its use as an ingredient in blends intended for high quality applications. The present study addressed this issue by undertaking a systematic evaluation of the odor properties and constituent odorants of commercially available lignins and related high-density polyethylene (HDPE) blends. The potent odors of the investigated samples could be attributed to the presence of 71 individual odorous constituents that originated primarily from the structurally complex lignin. The majority of them was assignable to six main substance classes: carboxylic acids, aldehydes, phenols, furan compounds, alkylated 2-cyclopenten-1-ones, and sulfur compounds. The odors were strongly related to both the lignin raw materials and the different processes of their extraction, while the production of the blends had a lower but also significant influence. Especially the investigated soda lignin with hay- and honey-like odors was highly different in its odorant composition compared to lignins resulting from the sulfurous kraft process predominantly characterized by smoky and burnt odors. These observations highlight the importance of sufficient purification of the lignin raw material and the need for odor abatement procedures during the compounding process. The molecular elucidation of the odorants causing the strong odor represents an important procedure to develop odor reduction strategies.
An Essential Role of Polymeric Adhesives in the Reinforcement of Acidified Paper Relics
Authors: Liu Jiaojiao , Xing Huiping , Zhou Yajun , Chao Xiaolian , Li Yuhu , Hu Daodao
Published: January 2022

Paper acidification causes paper relics to undergo embrittlement and decay, to form dregs, and even to break upon a single touch; therefore, reinforcement and deacidification treatments are essential steps for paper conservation and to retard the deterioration and prolong the life of objects. Polymeric adhesives play an essential role in reinforcement and deacidification treatments, although it is not well studied. In this work, the effect of polymeric adhesives on the conservation process and their protective effects on acidified paper relics were studied. Firstly, three polymeric adhesives, including wheat starch paste, polyvinyl butyral (PVB), and polyvinyl alcohol (PVA), were selected as research objects. Subsequently, their effects on four popular conservation methods were further discussed, including traditional mounting, hot-melt with silk net, alcohol-soluble cotton mesh, and water-soluble cotton mesh. Additionally, as an example, the reversibility and long-term durability of water-soluble adhesive PVA-217 were assessed. Using a computer measured and controlled folding endurance tester, pendulum tensile strength tester, tear tester, burst tester, FT-IR, video optical contact angle tester, and other instruments, the conservation application of water-soluble adhesives in paper relics was evaluated. This study provides a scientific basis and experimental data for the application of polymeric adhesives in the conservation of paper relics.
How Fiber Surface Topography Affects Interactions between Cells and Electrospun Scaffolds: A Systematic Review
Authors: Lopez Marquez Alex , Gareis Iván Emilio , Dias Fernando José , Gerhard Christoph , Lezcano María Florencia
Published: January 2022

Electrospun scaffolds have a 3D fibrous structure that attempts to imitate the extracellular matrix in order to be able to host cells. It has been reported in the literature that controlling fiber surface topography produces varying results regarding cell–scaffold interactions. This review analyzes the relevant literature concerning in vitro studies to provide a better understanding of the effect that controlling fiber surface topography has on cell–scaffold interactions. A systematic approach following PRISMA, GRADE, PICO, and other standard methodological frameworks for systematic reviews was used. Different topographic interventions and their effects on cell–scaffold interactions were analyzed. Results indicate that nanopores and roughness on fiber surfaces seem to improve proliferation and adhesion of cells. The quality of the evidence is different for each studied cell–scaffold interaction, and for each studied morphological attribute. The evidence points to improvements in cell–scaffold interactions on most morphologically complex fiber surfaces. The discussion includes an in-depth evaluation of the indirectness of the evidence, as well as the potentially involved publication bias. Insights and suggestions about dose-dependency relationship, as well as the effect on particular cell and polymer types, are presented. It is concluded that topographical alterations to the fiber surface should be further studied, since results so far are promising.
Mucilage of Coccinia grandis as an Efficient Natural Polymer-Based Pharmaceutical Excipient
Authors: Ilango Kumbakonam Balachandran , Gowthaman Senguttuvan , Seramaan Kumbakonam Ilango , Chidambaram Kumarappan , Bayan Mohammad F. , Rahamathulla Mohamed , Balakumar Chandrasekaran
Published: January 2022

Natural eco-friendly materials are recently employed in products to replace synthetic materials due to their superior benefits in preserving the environment. The herb Coccinia grandis is widely distributed in continents like Asia and Africa and used traditionally to treat fever, leprosy, asthma, jaundice, and bronchitis. Mucilage of Coccinia grandis was accordingly extracted, isolated by a maceration technique, and precipitated. The mucilage was evaluated for its physicochemical, binding, and disintegrant properties in tablets using paracetamol as a model drug. The crucial physicochemical properties such as flow properties, solubility, swelling index, loss on drying, viscosity, pH, microbial load, cytotoxicity was evaluated and the compatibility was analyzed using sophisticated instrumental methods (TGA, DTA, DSC, and FTIR). The binding properties of the mucilage was used at three different concentrations and compared with starch and PVP as examples of standard binders. The disintegrant properties of mucilage were used at two different concentrations and compared with standard disintegrants MCCP, SSG, and CCS. The tablets were punched and evaluated for their hardness, friability, assay, disintegration time, in vitro dissolution profiles. In vitro cytotoxicity studies of the mucilage were performed in a human embryonic kidney (HEK) cell line. The outcome of the study indicated that the mucilage had good performance compared with starch and PVP. Further, the mucilage acts as a better disintegrant than MCCP, SSG and CCS for paracetamol tablets. Use of a concentration of 3% or less demonstrated the ability of the mucilage to act as a super disintegrating agent and showed faster disintegration and dissolution, which makes it as an attractive, promising disintegrant in formulating solid dosage forms to improve the therapeutic efficacy and patient compliance. Moreover, the in vitro cytotoxicity evaluation results demonstrated that the mucilage is non-cytotoxic to human cells and is safe.