bluuebunny/crossref_metadata_2025 huggingface dataset:
O “eco” do marxismo: o metabolismo social do capital e o pensamento ambiental | The “echo” of Marxism: the social metabolism of capital and environmental thinking
Authors: Silva Luiz Felipe Barros
Published: January 2019

As teorias de Karl Marx e Friedrich Engels reverberaram nos diversos campos da ciência, dando margem a variadas interpretações de seus pensamentos, muitas delas apressadas em taxá-los de economicistas ou deterministas antinatureza. No pensamento ecológico e ambiental, estas interpretações ainda possuem muitos seguidores; por isso, o presente artigo vem trazer uma interpretação diferente do pensamento marxista ancorado sobretudo em Guillermo Foladori e John Bellamy Foster, que não antepõem o legado de Marx e Engels à luta pela defesa da natureza. Pelo contrário, esses autores entendem que Marx e Engels revelaram ao mundo os constituintes internos do metabolismo social do capital, o modo de produção mais avassalador para com a natureza já existente, e, assim, são perfeitamente compatíveis como mediação teórica para a superação deste sistema social que vem colocando a sobrevivência humana em risco quanto mais reproduz seus antagonismos.Palavras-Chave: Marx e a ecologia; natureza em Marx; capital e meio ambiente; marxismo; ambientalismo.  Abstract – The theories of Karl Marx and Friedrich Engels reverberated in diverse fields, giving margin to different readings. Many hurried to label them as economicists and anti-nature determinists. In ecological and environmental thinking, these interpretations still have many followers; therefore, this article brings a different interpretation of Marxist thought anchored mainly in Guillermo Foladori and John Bellamy Foster, who do not pit the legacy of Marx and Engels against the defense of nature. Instead, they understand Marx and Engels revealed to the world the internal constituents of the social metabolism of capital, the production mode that is most overwhelming for nature, and so they are perfectly compatible as a theoretical mediation to overcome this social system that is putting human survival at risk as it reproduces its antagonisms.Keywords: Marx and ecology; nature in Marx; capital and environment; Marxism; ambientalism.
Secularização, laicidade e cosmovisões em conflito: o espaço da religião na esfera pública
Authors: Reis de Albuquerque Adriana
Published: January 2019

O presente artigo tem por objetivo discutir o espaço da religião na esfera pública, dentro de um Estado de direito de viés democrático. O texto evidencia como o desenvolvimento do Estado constitucional de cunho liberal influenciou a superveniência de uma concepção restritiva do papel da religião na esfera pública, criando um conceito de tolerância enquanto “indiferença”, a partir de uma absoluta dissociação entre o público e o privado. Correlaciona o fortalecimento da visão que afasta o elemento religioso do debate público e da esfera institucional do Estado com a cosmovisão pós-moderna. A partir da distinção entre Estado e sociedade, defende a ineficácia do conceito de tolerância liberal para lidar com uma sociedade que deve ser caracterizada como “pós-secular”, a demandar que o Estado dialogue com o elemento religioso. A partir do referencial teórico de Jurgen Habermas e Michael Sandel, o artigo defende não só a possibilidade, como a efetiva necessidade de que, cumpridos determinados pressupostos epistemológicos, o argumento religioso seja incorporado ao debate político e mesmo institucional, mediante a substituição da ideia de neutralidade como “indiferença” por neutralidade como “inclusão”, possibilitando o surgimento de um cenário social e jurídico de maior comprometimento com as divergências morais e maior densidade democrática.
Examining the Relationship between Referee Performance and Self-Efficacy
Authors: Karacam Aydin , Adiguzel Niyazi Sidki
Published: January 2019

The aim of the study was to examine the relationship between basketball referees' performance scores gained during a season and their self-efficacy levels. The study was conducted in correlational design and the accessible sampling method was used for the sample selection. The sample of the study consisted of 64 Class-B referees (2% (n=3) were females and 98% (n=61) were males) who actively served in the 2016-2017 season within Turkish Basketball Federation. A demographic information form, "The Referee Self-Efficacy Scale" developed by Karacam and Pulur, and performance scores calculated by the Central Arbitration Committee of Turkish Basketball Federation were used as data collection tools. Data analysis was conducted using SPSS 21 and AMOS programs. The Pearson-Product Moments Correlation Coefficient was used to determine the relationships between the variables. As a result, a positive significant relationship was found between basketball referees' physical fitness, game knowledge, decision-making, pressure, communication, REFS total score, and their performance scores and the variables age and the number of matches refereed. Moreover, a positive significant relationship was found between basketball referees' physical fitness, game knowledge, decision-making, pressure, communication, and REFS total score and their performance scores.
The Role Of Purse String Closure As The Primary Treatment Of Hemangioma
Authors: Wardhana Aditya , Atmaja Tessa M.
Published: January 2019

Hemangioma is a common congenital disorder which happens in neonates or infant, with predilection sites in the face and neck. Not every case of hemangioma requires a surgical treatment. Some will regress spontaneously. In some cases which requires resection, the aesthetic aspects of the repair must be considered as the sites of the lesion involved the face and neck areas, which is greatly exposed.Two patients with hemangioma of the left cheek were admitted to Plastic Surgery Department of Cipto Mangunkusumo Hospital. The patients underwent excision and primary closure with purse string technique. Patients were evaluated at one week after surgery and a month after to assess scar appearance. Follow up evaluation revealed less visible scar compared to the immediate result. A well-known technique used by many plastic surgeons is the circular incision followed by purse-string closure. The use of this technique was known to produce less visible scar. Hemangiomas acts as a tissue expander, which make it applicable to close the defect using purse string closure.
Innervated Bilobed Radial Forearm Free Flap For Tongue Reconstruction
Authors: Atmodiwirjo Parintosa , Bangun Kristaninta , Handayani Siti , Djamaloeddin Chaula , Nindita Eliza
Published: January 2019

Hemiglossectomy defects need reconstructions to restore normal functions and aesthetic outcomes. It is therefore prudent that well-planned reconstructive technique is needed for a good functional substitution for the defect.This case report describes a 30 years old male who developed T2N1M0 squamous cell carcinoma of the left tongue. The patient underwent a tongue reconstruction following his hemiglossectomy involving floor of the mouth without mandibular resection.The optimum method of reconstructing a major defect such as hemiglossectomy with floor of the mouth resection is best carried out by using microvascular free tissue transfer.  We conclude that the radial forearm free flap is good method for reconstructing major defects of the tongue. The radial forearm free flap is thin, can be raised without patient position change, has constant vascular anatomy, and provides an advantage in the aesthetic aspect at the donor site.
Microsurgery Technique in the Foot Reconstruction of Soft Tissue Defects: A Review of 4 Cases
Authors: Atmodiwirjo Parintosa , Sandhi Afriyanti
Published: January 2019

The restoration of an intact covering is the primary surgical requisite following soft tissue defects in the foot because deep healing can be no better than the surface covering. Soft tissue defects that expose underlying bones, joints, and tendons pose challenging problems and require a free tissue transfer for a successful reconstruction.Total of 4 flaps in the foot was performed between February 2009 to February 2010. We reconstructed soft tissue defects in the foot in 4 patients using 3 free anterolateral thigh (ALT) flaps and 1 free radial forearm (RF) flap. Trauma was the commonest cause in our patients.Free ALT and RF flaps provided stable and durable long-term wound cover in all patients. Complications were few and manageable.Free tissue transfer has become commonplace in many centers around the world. The numerous advantages include stable wound coverage; improve aesthetic and functional outcomes, and minimal donor site morbidity. In our experience, we found that the using of free ALT and RF flaps in foot defects reconstruction, to be technically affordable, reliable and have resulted in excellent outcomes.
The Advantages of Vascularized Fibular Bone Graft For Mandibular Tumor Reconstruction
Authors: Atmodiwirjo Parintosa , Putri Nandita Melati
Published: January 2019

Mandibular reconstruction are often indicated in patient who underwent ablation or excision of the mandible due to malignancy of the oral cavity.In this paper we will discuss about the mandibular reconstruction with use of alloplastic implant, and vascularized bone graft. Four cases of oral cavity tumor which were referred to the plastic surgery division at Cipto Mangunkusumo hospital during 2005-2011, after being diagnosed with oral cavity tumor were re-viewed. Mandibular reconstruction can be done using alloplastic implant, non-vascularized bone graft or vascularized bone graft. In this paper we studied four patients who needed mandibular reconstruction after ablation of oral cavity tumors. Patients who underwent reconstruction with alloplastic implants all had complications such as broken hardware. Where as in patient who underwent free fibular tissue transfer there were no complications at all. We can conclude that in less vascularized surrounding tissue as in cases that received or will receive other treatment such as chemotherapy or radiation that vascularized bone graft are superior. The bone healing in vascularized bone graft also does not depend on creeping substitution like in non vascularized bone graft.
Synechia of Major Labia and It’s Operative Technique: A Case Report
Authors: Samiadji Muhammad , Pudjisriyani Pudjisriyani , Swantari Ni Made , Sukasah Chaula L.
Published: January 2019

Background: Labial synechia (labial fusion or labial adhesion) is a clinical entity rarely seen in adults. Labial synechia are usually caused by a combination of local inflammation, chronic infection and estrogen deficiency. This condition is not life threatening, but severe cases usually result in urinary problems.Methods: A case report based on the medical and surgical records was done. We found one case of labial synechia on a 65 years old female which was referred to plastic and reconstructive surgery department from the Gynecology department.Results: The reconstructive surgery was performed with two stage. Local anaestethic adhesiolysis as the first treatment then continued with general anesthesia reconstruction using both labial advancement flap to close the mucous defect. Patient was stay in the hospital in 5 days, and the flap to reconstruct the labia was vital.Conclusion: Multifactorial causes such as chronic infection, chronic inflammation, poor hygiene and history of systemic disease can be the etiology. Surgical approach is the best choice for this case because the synechia causes urinary problems.
Food Hypersensitivity as a Cause of Atopic Dermatitis
Authors: Santoso Hendra
Published: January 2019

Thirty children from infancy to 12 years suffering from atopic dermatitis were evaluated for food hypersensitivity by means of history, skin prick test, total eosinophils count, and elimination of suspected food. Sixteen (53%) patients had history of allergy to suspected food, the other 16 (53%) had ether allergic diseases. Of the 30 patients, 15 (50%) had one of the parents with allergic diseases, and in 3 patients both parents suffered from a1Iergic diseases. Nineteen (6:3-1.) children had atopic dermatitis triggered by food; egg accounted for 400/o, fish for 53-lo and shrimp for 40% for the allergic manifestations. Skin prick test consisted of 20 food allergens was done to all children above 2 years of age, 12 (40%) of the pa1ients showed positive results. This study demonstrated that food hypersensitivity may play a pathogenic role in some children with atopic dermatitis. Appropriate diagnosis and restriction of diet can improve their skin symptoms.
Some Risk Factors for Low Birthweight Infants at Manado Hospital
Authors: W. S. M. Salendu , Raharjo Sutomo , Mustadjab Immanuel , Warouw Nan
Published: January 2019

The risk factors of low birthweight infants were assessed in a retrospective study covering 3607 singleton livebirth infants at Manado Hospital from January until December 1993. The analysis confirmed that patterns of risk birthweight hypertension in pregnancy (P<0.01), maternal education (P<0.01), maternal age (P<0.05), and parity (P<0.01), marital status (P<0.01), history of abortion (P<0.05), and parity (P<0.01). Anemia in pregnancy was also associated with birthweight in low birth weight (P<0.05). Asymetric intrauterine growth retardation (Ponderal Index below 2.32) was found both in premature and term infants.
A METHOD OF COMPLEX CALCULATION OF RATIONAL STRUCTURAL PARAMETERS OF RAILWAY HUMPS
Authors: Panchenko Sergii , Ohar Oleksandr , Kutsenko Maksym , Smachilo Julia
Published: January 2019

The article deals with a method of complex calculation of rational structural parameters of humps at classification yards. Unlike existing methods, this method allows an implementation of the technology of guided gravity regulation of the cut speed by applying a special layout and profile arrangement. The authors believe that it will decrease the maintenance costs to refund damaged car and cargo, costs on electricity needed for the cut speed regulation and some extra charges due to demurrages caused by waiting for breaking-up at arrival yards.
ANALISIS PENYIMPANGAN PENGGUNAAN LAHAN BERDASARKAN RENCANA TATA RUANG WILAYAH KABUPATEN SUMEDANG
Authors: Khaerani Reny , Sitorus Santun R.P. , Rusdiana Omo
Published: January 2019

Spatial plan is the result of spatial planning which is done through the process and procedure of arranging and determining based on the prevailing laws and regulations. The phenomenon that often happens is the deviation of existing land use with spatial plan. Sumedang Regency is experiencing a fairly rapid development, so there is an increase in human resource activity that implicate the widespread space needs and consequently deviation of land use is very vulnerable. The purpose of this study to determine the extent of deviation of land use occurs as well as what factors affect the occurence of irregular use of land. The analysis used in this study using GIS approach, Principal Component Analysis and Multiple Regression Analysis. The result of analysis shows that there are 25 types of deviation of existing land use and the most dominant is deviation into wetland (18,364 ha), dryland field (8,405 ha) and widened land (7,741 ha). While the factors that influence the occurence of deviation of land use are population and settlement, availability of land, infrastructure and accessibility, and sosioeconomic condition of society
Accounting and its Relationship to General Equilibrium Theory
Authors: Shubik Martin
Published: January 2019

Accounting both for macro and microeconomic purposes deals with process and dynamics. Much of the best microeconomic theory has dealt only with statics. General equilibrium theory shows the virtues of a price system, but abstracts from price formation and all of the accounting problems which appear in disequilibrium. An approach is suggested here for reconciliation of accounting with general equilibrium. More generally, it is suggested that the importance of accounting to economic theory has been underestimated.
Metabolic syndrome and associated factors in Iranian children and adolescents: the CASPIAN-V study
Authors: Heshmat Ramin , Hemati Zeinab , Qorbani Mostafa , Nabizadeh Asl Laleh , Motlagh Mohammad Esmaeil , Ziaodini Hasan , Taheri Majzoubeh , Ahadi Zeinab , Shafiee Gita , Aminaei Tahereh , Hatami Hooman , Kelishadi Roya
Published: January 2019

Introduction: Metabolic syndrome (MetS) is one of the common metabolic disorders seen in children and adolescents. This study aims to assess the rate of the MetS and its associated factors in a nationally-representative sample of Iranian pediatric age groups. Methods: This nationwide cross- sectional study was designed in 2015 in 30 provinces of Iran. Participants consisted of 4,200 school students, aged 7-18 years, studied in a national school-based surveillance program (CASPIAN-V). Physical examination and laboratory tests were performed using standard protocols. Blood samples were drawn from 3834 students for biochemical tests. Results: The participation rate for blood sampling was 91.5%. MetS was significantly more prevalent among students in urban than in rural areas (5.7% vs. 4.8%, P value < 0.01). MetS was more prevalent in students with obese parents than in those with non-obese parents (6.4% vs. 4.5%, P value < 0.05). Significant association existed between moderate level of healthy nutritional behaviors and MetS after controlling for potential confounders (odds ratio [OR]: 0.62, 95% CI: 0.40-0.98). Students with high unhealthy nutritional behaviors showed an increased risk of MetS in crude (OR: 1.6, 95% CI: 1.05-2.44) and adjusted model (OR: 1.65, 95% CI: 1.05-2.63). Conclusion: High rate of MetS and associated risk factors was observed in Iranian pediatric age groups, with higher rates among boys. These findings provide useful information for effective preventive strategies based on diet, exercise, and lifestyle modification rather than therapeutic modalities.
Reibungsgewinne. Identitäten im Inner[Außer]Halb
Authors: Frühwirth Angelika , Mijić Ana
Published: January 2019

Wer bleiben möchte, hat sich anzupassen; wer ansprechen möchte, hat spezifischen Idealen zu entsprechen; wer leben möchte, hat zu funktionieren. Ausgehend von diesen, in den Werken dreier Wiener Autorinnen mit „Jugoslawien“-Bezug identifizierten „Gesetzen“ einer erstarrten Wirklichkeit, widmet sich dieser Beitrag der Frage, wie Selbstbilder in verdinglichten Systemen entworfen werden und wie viel Platz dabei individuellen Freiheiten noch vorbehalten bleibt. Der literaturwissenschaftlichen Analyse dieser Werke wird die hermeneutische Interpretation von Gesprächen mit Menschen mit Migrationserfahrung dialogisch gegenüber gestellt. Dabei zeigen sich wesentliche Analogien zwischen dem Umgang der RomanprotagonistInnen mit einer erstarrten Wirklichkeit und den in den Interviews auftauchenden Strategien zum Entwurf von diasporischen Identitäten: Assimilation, Überkompensation, Erstarrung oder Resignation lassen sich sowohl aus den Romanen als auch aus den Interviews rekonstruieren. Hier und dort manifestieren sich aber auch widerständige Momente. Durch die gezielte Erzeugung von Reibung bemächtigen sich die im Inner[Außer]Halb Positionierten wieder der Kontrolle über ihre eigene Identität.
An Emotional Neglect–Personality Disorder Approach: Quantifying a Dimensional Transdiagnostic Model of Trauma-Related and Personality Disorders
Authors: Wildschut Marleen , Swart Sanne , Langeland Willemien , Smit Jan H. , Draijer Nel
Published: January 2019

Are personality disorders (PDs) associated with emotional neglect? Draijer (2003) developed a dimensional model of trauma-related disorders and PD. The first dimension consists of the severity of the trauma endured. The second dimension consists of emotional neglect, which is assumed to be related primarily to personality pathology. In this article, we investigate whether an association between retrospective reports of emotional neglect and the presence and severity of PD exists. A sample of 150 patients was systematically assessed. Results indicate that there is little evidence to support a link between emotional neglect and problematic personality functioning at the disorder level; however, there might be a link between emotional neglect and problematic personality functioning in a dimensional way. Findings indicate a relationship between lack of parental warmth and problematic personality functioning, supporting the existence of the emotional neglectaxis of the proposed model in a dimensional framework of viewing personality pathology.
Rejection Sensitivity and Borderline Personality Disorder Features: The Mediating Roles of Attachment Anxiety, Need to Belong, and Self-Criticism
Authors: Sato Momoko , Fonagy Peter , Luyten Patrick
Published: January 2019

Rejection hypersensitivity has been considered the core feature of patients with borderline personality disorder (BPD). However, little is known about the possible developmental mechanisms that might explain the association between rejection sensitivity and BPD features. The current study investigated the mediating roles of adult attachment, need to belong, and self-criticism in the association between rejection sensitivity and BPD features in 256 healthy adults. Results indicated that attachment anxiety, need to belong, and self-criticism mediated the association between rejection sensitivity and BPD features. However, attachment anxiety and self-criticism did not moderate the mediated association between rejection sensitivity and BPD features. The findings suggest that individuals with high rejection sensitivity are more likely to be anxiously attached to significant others, which might increase the desire to be accepted by others. To satisfy this elevated need to affiliate with others, these individuals might become more self-critical, which may contribute to high BPD features.
Postmeal Optogenetic Inhibition of Dorsal or Ventral Hippocampal Pyramidal Neurons Increases Future Intake
Authors: Hannapel Reilly , Ramesh Janavi , Ross Amy , LaLumiere Ryan T. , Roseberry Aaron G. , Parent Marise B.
Published: January 2019

Memory of a recently eaten meal can serve as a powerful mechanism for controlling future eating behavior because it provides a record of intake that likely outlasts most physiological signals generated by the meal. In support, impairing the encoding of a meal in humans increases the amount ingested at the next eating episode. However, the brain regions that mediate the inhibitory effects of memory on future intake are unknown. In the present study, we tested the hypothesis that dorsal hippocampal (dHC) and ventral hippocampal (vHC) glutamatergic pyramidal neurons play a critical role in the inhibition of energy intake during the postprandial period by optogenetically inhibiting these neurons at specific times relative to a meal. Male Sprague Dawley rats were given viral vectors containing CaMKIIα-eArchT3.0-eYFP or CaMKIIα-GFP and fiber optic probes into dHC of one hemisphere and vHC of the other. Compared to intake on a day in which illumination was not given, inhibition of dHC or vHC glutamatergic neurons after the end of a chow, sucrose, or saccharin meal accelerated the onset of the next meal and increased the amount consumed during that next meal when the neurons were no longer inhibited. Inhibition given during a meal did not affect the amount consumed during that meal or the next one but did hasten meal initiation. These data show that dHC and vHC glutamatergic neuronal activity during the postprandial period is critical for limiting subsequent ingestion and suggest that these neurons inhibit future intake by consolidating the memory of the preceding meal.
José Benjamín Bernal Suárez: Derecho humano a la familia. Retos y alcances en el siglo XXI, UAEM y GEDISA editorial, México, 2017, 174 páginas.
Authors: Bernal Ballesteros María Jose
Published: January 2019

El derecho a la familia suele ser abordado desde la rama del derecho privado, es decir todo lo concerniente al estado de las personas. No obstante, la novedad que presenta el libro Derecho Humano a la familia. Retos y alcances en el siglo XXI  es que a diferencia de lo anterior, aborda el tema del derecho a la familia desde la óptica de los derechos humanos.La primera justificación que hace el autor para sostener esta teoría se basa en la naturaleza jurídica y en la esencia misma de la familia, desde esta perspectiva entiende que “al ser una instrucción natural, la familia existe por la propia naturaleza del hombre” y que en este sentido “negar este derecho es como negarle al hombre el carácter de persona, el dominio sobre su propio ser”.En consecuencia de lo anterior y desde una postura iusnaturalista, el autor retoma la conceptualización de los derechos humanos y su relación con la dignidad para reafirmar su propuesta.
Виховання доброзичливості у дітей дошкільного віку як педагогічна проблема
Authors: Pisotska Leonida
Published: January 2019

У статті розкрито актуальність виховання доброзичливості у дітей дошкільного віку, обумовлену необхідністю гуманізації внутрішнього світу особистості, підвищенням духовного потенціалу кожного, утвердженням ідеалів добра, честі, милосердя, виховання, починаючи з дошкільного віку, готовності кожної особистості до конструктивної взаємодії з оточуючим світом. Акцентовано увагу на різних трактуваннях поняття “доброзичливість”. Розкрито окремі форми роботи з дітьми дошкільного віку щодо виховання доброзичливості у них.
Полікультурне виховання особистості крізь призму праць М. Г. Стельмаховича
Authors: Atroshchenko, Tetiana
Published: January 2019

У статті розкрито проблему полікультурного виховання особистості з урахуванням основоположних ідей наукової спадщини М. Стельмаховича. Схарактери-зовано поняття “полікультурне виховання”. Проаналізовано науковий погляд М.Стель-маховича щодо виховання особистості, міжетнічних стосунків, провідної ролі родини у формуванні високоморального толерантного громадянина, здатного цінувати культурні надбання як власного, так й інших народів. Розкрито поняття етнізації через концепцію М.Стельмаховича, в яке науковець вкладає поняття соціалізації особи на основі родинного, економічного, духовно-культурного життя й історичного досвіду свого народу, нації.
Whole-Genome Multi-omic Study of Survival in Patients with Glioblastoma Multiforme
Authors: Bernal Rubio Yeni L , González-Reymúndez Agustin , Wu Kuan-Han H , Griguer Corinne E , Steibel Juan P , de los Campos Gustavo , Doseff Andrea , Gallo Kathleen , Vazquez Ana I
Published: January 2019

Glioblastoma multiforme (GBM) has been recognized as the most lethal type of malignant brain tumor. Despite efforts of the medical and research community, patients’ survival remains extremely low. Multi-omic profiles (including DNA sequence, methylation and gene expression) provide rich information about the tumor. These profiles are likely to reveal processes that may be predictive of patient survival. However, the integration of multi-omic profiles, which are high dimensional and heterogeneous in nature, poses great challenges. The goal of this work was to develop models for prediction of survival of GBM patients that can integrate clinical information and multi-omic profiles, using multi-layered Bayesian regressions. We apply the methodology to data from GBM patients from The Cancer Genome Atlas (TCGA, n = 501) to evaluate whether integrating multi-omic profiles (SNP-genotypes, methylation, copy number variants and gene expression) with clinical information (demographics as well as treatments) leads to an improved ability to predict patient survival. The proposed Bayesian models were used to estimate the proportion of variance explained by clinical covariates and omics and to evaluate prediction accuracy in cross validation (using the area under the Receiver Operating Characteristic curve, AUC). Among clinical and demographic covariates, age (AUC = 0.664) and the use of temozolomide (AUC = 0.606) were the most predictive of survival. Among omics, methylation (AUC = 0.623) and gene expression (AUC = 0.593) were more predictive than either SNP (AUC = 0.539) or CNV (AUC = 0.547). While there was a clear association between age and methylation, the integration of age, the use of temozolomide, and either gene expression or methylation led to a substantial increase in AUC in cross-validaton (AUC = 0.718). Finally, among the genes whose methylation was higher in aging brains, we observed a higher enrichment of these genes being also differentially methylated in cancer.
Combinatorial Genetic Control of Rpd3S Through Histone H3K4 and H3K36 Methylation in Budding Yeast
Authors: Lee Kwan Yin , Ranger Mathieu , Meneghini Marc D
Published: January 2019

Much of euchromatin regulation occurs through reversible methylation of histone H3 lysine-4 and lysine-36 (H3K4me and H3K36me). Using the budding yeast Saccharomyces cerevisiae, we previously found that levels of H3K4me modulated temperature sensitive alleles of the transcriptional elongation complex Spt6-Spn1 through an unknown H3K4me effector pathway. Here we identify the Rpd3S histone deacetylase complex as the H3K4me effector underlying these Spt6-Spn1 genetic interactions. Exploiting these Spt6-Spn1 genetic interactions, we show that H3K4me and H3K36me collaboratively impact Rpd3S function in an opposing manner. H3K36me is deposited by the histone methyltransferase Set2 and is known to promote Rpd3S function at RNA PolII transcribed open reading frames. Using genetic epistasis experiments, we find that mutations perturbing the Set2-H3K36me-Rpd3S pathway suppress the growth defects caused by temperature sensitive alleles of SPT6 and SPN1, illuminating that this pathway antagonizes Spt6-Spn1. Using these sensitive genetic assays, we also identify a role for H3K4me in antagonizing Rpd3S that functions through the Rpd3S subunit Rco1, which is known to bind H3 N-terminal tails in a manner that is prevented by H3K4me. Further genetic experiments reveal that the H3K4 and H3K36 demethylases JHD2 and RPH1 mediate this combinatorial control of Rpd3S. Finally, our studies also show that the Rpd3L complex, which acts at promoter-proximal regions of PolII transcribed genes, counters Rpd3S for genetic modulation of Spt6-Spn1, and that these two Rpd3 complexes balance the activities of each other. Our findings present the first evidence that H3K4me and H3K36me act combinatorially to control Rpd3S.
Teodoro Lepnerio apybraižos „Prūsų lietuvis“ citatos Simono Daukanto veikale „Būdas senovės lietuvių, kalnėnų ir žemaičių“
Authors: Bončkutė Roma
Published: January 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Straipsnyje analizuojamos Teodoro Lepnerio (Theodorus Lepner, 1633–1691) etnografinės apybraižos „Der Preuſche Littauer“ (1744; „Prūsų lietuvis“) citatos ir nuorodos Simono Daukanto veikale „BUDĄ Senowęs–Lëtuwiû Kalnienû ir Ƶámajtiû“ („Būdas senovės lietuvių, kalnėnų ir žemaičių“). Tiriama S. Daukanto pažinties su „Prūsų lietuvio“ tekstu raida. Aptariamas Lietuvių literatūros ir tautosakos institute saugomas S. Daukanto rankraštis „Marguminai“ ir jame esančios T. Lepnerio knygos citatos, t. y. citatų išrašų istorija, datavimas, turinys. Nagrinėjamas istoriko darbo su šaltiniais pobūdis. Straipsnyje analizuojama 31 nuoroda, citavimo ypatumai ir citatų turinys. Manoma, kad S. Daukantas, turėdamas remtis veikalu, kur Prūsijos kunigaikštystės lietuvis pavaizduotas kaip marginalios mažumos atstovas, keistas sarkazmo vertas objektas, a priori pasirinko faktų reinterpretacijos kelią. Iš subjekto pozicijos ėmęsis aprašyti lietuvių būdą, praeitį, S. Daukantas atliko šaltinio istorinį revizionizmą. T. Lepnerio teksto revizionizmas lėmė citavimo pobūdį: vyrauja parafrazės, laisvas autoriaus minčių persakymas, šaltinio duomenų koreliacijos ir priežastingumo keitimas. Išvadose apibendrinamos S. Daukanto veikale esančios sąsajos su T. Lepnerio tekstu. Nustatyta, kad S. Daukantas gana tiksliai pakartoja šaltinio tekstą ir pateikia tikslią nuorodą 17 kartų. 8 kartus istorikas nurodo klaidingai: nei turinio, nei puslapių požiūriu nėra atitikimo. 6 nuorodų turinys yra imtas iš šaltinio, bet netiksliai pateikti skyrių ir puslapių numeriai.
Vokietijos metraščiui „Annaberger Annalen über Litauen und deutsch-litauische Beziehungen“ – ketvirtis amžiaus
Authors: Hermann Arthur
Published: January 2019

[straipsnis ir santrauka lietuvių kalba; santrauka anglų kalba]

Tyrimo objektas yra Vokietijoje nuo 1993 m. leidžiamas metraštis „Annaberger Annalen über Litauen und deutsch-litauische Beziehungen“ („Anabergo analai apie Lietuvą bei vokiečių ir lietuvių santykius“). Per 25 metus tradiciniu ir skaitmeniniu būdu paskelbti 26 tomai, kuriuos sudaro 221 autoriaus pateiktų 318 straipsnių, apimančių 7440 puslapių. Rengia ir leidžia iniciatorių grupė Arthur Hermann, Annemarie Lepa, dr. Christina Nikolajew ir dr. Lina Pilypaitytė. Užsakovai yra Baltischer Christlicher Bund (Bonn) ir Litauisches Kulturinstitut (Lampertheim). Nusistovėjo tradicija moksliniams straipsniams kiekviename tome skirti du trečdalius puslapių, trečdalį – kitokio pobūdžio publikacijoms. Tyrimų nuolat gausėja. Anksčiau plačiau tyrinėti Vokiečių Ordino ir Lietuvos Didžiosios Kunigaikštystės santykiai, šiandien daugiau rašoma XIX–XX a. Vokietijos ir Lietuvos ryšių bei kitomis temomis, Rytų Prūsijos, Klaipėdos krašto gyventojų ir paveldo klausimais. Metraščio spausdintinės versijos abonentų yra apie 100, skaitmeninės – tūkstančiai. Metraščio ateitis nėra aiški dėl finansavimo problemų.
Construction sands of Podillya: patterns of distribution, resources and use
Authors: Syvyj M. , Gavrychok B.
Published: January 2019

This article presents the characteristics of the resource base of building sands within the three Podillya regions, the patterns of sands distribution, and proposals for increasing the extraction of raw materials . The construction sands of Podillya are confined to the Upper Cretaceous, Neogene and Anthropogenicdeposits. The decrease of the thickness of the sandy strata of the Opilsk Neogene suite in the eastern direction was observed with the simultaneous increase in the thickness of the overlapping strata of the rocks. There is no apparent correlation between the thickness of sandy interlayers and the quality of sands. The interdependence of the chemical composition of Neogene sands and the sand size module is established.The genetic predisposition for the distribution of building sands in different parts of the Podillya territory has been established. Four groups of sand deposits of different age have been identified within the Podillya regions, which contrast sharply with single deposits in the neighbouring territories.There is a very uneven distribution of explored reserves of sandy raw materials across the region and accordingly in the provision of construction sands in the different oblasts /regions of Podillya. The areas best provided with sandy raw materials are the central districts of Ternopil region and Slavutsky district of Khmelnytsky region . Sands of the Baltic stage distributed in Vinnytsia region are mostly poor in quality, clogged with clay material and require enrichment. The further development of the mineral raw material base and the prospects for increasing the production of construction sand in the Podillya regions is associated with the increase in production at the prepared deposits, the commissioning of reserve deposits, the conducting of prospecting and exploration work in the proposed potentially exploitable areas and additional exploration of individual deposits that are exploited. The research allows us to evaluate objectively the existing base of sand raw materials for various purposes in the Podillya region and to develop on this basis measures to increase it. The importance of the study is determined by the acute shortage of the raw material in most administrative districts of Khmelnytsky and Vinnytsia regions, by the growth in the volume of construction work (and accordingly the requirements for sandy raw materials) both in Podillya and in the country.
Periodization of the studies of territorial organization of recreation and tourism
Authors: Yavorska V. V. , Hevko I. V. , Sych V. A. , Kolomiyets K. V.
Published: January 2019

The article deals with the main periods of formation of views on the territorial organization of recreation and tourism from the moment of the establishment of tourism as an independent sphere of activity to the present. It is stressed that a great deal of scientific works are devoted to the territorial organization of recreation and tourism, which has a hierarchical multilevel structure with a system of various connections. The purpose of this study is to periodize the scientific approaches to the territorial organization of recreation and tourism, as well as to identify current trends in this field. It was established that the first period is based on the understanding of tourism as a systemic phenomenon, during this period the concept of territorial recreational systems was developed, and at the same time, the basis of the study of the causes of territorially uneven development of tourism was laid. At this stage, researchers began to pay more attention to the role of behaviour, and to general psychological factors that motivate potential consumers of tourist products, to the perception oftourists of destinations. The second period is characterized by the spread of the concept of tourist destination and the beginning of the use of clusters in the tourism sector. The third period is marked by the center-peripheral model of tourism development, the possibility of transformation of the territorial organization of tourism through globalization processes, the emphasis on the environmental components of tourism activity. The most developed means of organizing a territory is recreation and tourism zoning, which traditionally serves as the scientific basis of territorial planning and tourism complex management, and is important in the implementation of tourism infrastructure development programmes. Among the current trends in the spatial organization of tourism activities the process of clusterization is noted, which spatially occurs both on the local and global levels. One of the characteristicfeatures of the cluster as the concentration of interacting and simultaneously competing enterprises is the developed network of horizontal ties, the importance of cooperation at different levels for synergetic effect. It is determined that the characteristic feature of the recreational-tourist cluster is not only the complementarity of the enterprises belonging to it, but also the impossibility of operating them outside the recreational and tourist sphere.
A disciplina de Psicologia no Ensino Médio: revisitando as práticas dos professores da rede pública do Estado de São Paulo
Authors: Kohatsu Lineu Norio , Machado Lucas Antunes
Published: January 2019

Este artigo tem por objetivo apresentar e discutir os dados obtidos junto aos professores de Psicologia sobre suas práticas no ensino médio da rede pública do Estado de São Paulo. Participaram da pesquisa 20 professores de Psicologia, concursados e efetivos, de escolas públicas pertencentes a Diretorias de Ensino da Capital, da região metropolitana e do interior do Estado de São Paulo. Os dados coletados por meio de um questionário auto-aplicável mostraram que um dos principais objetivos do ensino de Psicologia era a formação crítica dos alunos. Em relação ao conteúdo programático, foram mencionadas algumas teorias psicológicas, mas muitos professores citaram principalmente o trabalho com temas do cotidiano dos alunos. Quanto à metodologia de ensino, foram citadas aulas expositivas dialogadas combinadas com atividades diversas como leitura de textos, seminários, debates com a utilização de diversos recursos como música, filmes etc. que visavam à realização de aulas participativas e aprendizagem significativa dos alunos. A avaliação combinava diversos instrumentos e procedimentos, realizados individualmente ou em grupo. Pelo destaque dado pelos professores ao trabalho com temas, buscou-se retomar, ainda que brevemente, algumas propostas pedagógicas que historicamente se apresentaram como alternativas à educação tradicional. Por fim, considera-se que as discussões sobre o ensino de Psicologia no nível médio remetem às reflexões mais gerais sobre o currículo e a formação dos jovens das escolas públicas, revelando as contradições e as disputas que são travadas historicamente na educação.
Aktualitások a sérült immunitású betegek cytomegalovirusinfekcióinak ellátásában. I. Epidemiológia és klinikai szempontok
Authors: Sinkó János
Published: January 2019

Abstract:

Human cytomegalovirus is a DNA virus with a global prevalence of 40–100%. In humans, primary infection is followed by a lifelong latent persistent phase. Even in individuals developing adequate specific immunity, interactions with the resident virus do probably occur. Clinically significant problems, however, appear primarily in immunocompromised hosts. As a result of an impaired T-cell mediated immunity, viral reactivation as well as a viral disease resulting in organ damage can develop. Most severely affected are HIV positive persons in AIDS stage and individuals undergoing solid organ or stem cell transplantation. As vital functions and survival may adversely be affected by cytomegalovirus reactivation and disease, it is of paramount significance to evaluate evident risk factors. Viral reactivation and organ specific disease can be detected by several methods based on conventional and molecular biological and histological diagnostic techniques. An up-to-date management of affected patient groups requires a meticulous assessment of the possible risk for cytomegalovirus infection and development of an adequate antiviral strategy. Orv Hetil. 2019; 160(3): 83–92.
New distributional record of Anthrenus dorsatus Mulsant & Rey, 1868 (Coleoptera, Dermestidae) on the island of Mallorca, Spain
Authors: Holloway Graham J. , Foster Christopher W. , Callaghan Amanda
Published: January 2019

The carpet beetle Anthrenus dorsatus has previously been recorded from North Africa and Malta. During a recent visit to the island of Mallorca several Anthrenus species were collected which included a number of Anthrenus dorsatus specimens. This record adds a new species both to the island of Mallorca and to the Spanish checklist. These records extend our knowledge of the distribution of A. dorsatus and provide more evidence of range expansion in the pimpinellae species group across Europe, possibly because of global climate change.
SALURAN PEMASARAN RUMPUT LAUT (Eucheuma cottonii) DI SUMBA TIMUR, NUSA TENGGARA TIMUR
Authors: Soejarwo Permana Ari , Yusuf Risna
Published: January 2019

ABSTRAKNusa Tenggara Timur merupakan produsen terbesar kedua setelah Sulawesi Selatan dalam produksi rumput laut jenis Eucheuma cottonii. Karena itu, peluang pengembangan rumput laut jenis E. cottonii sangat menjanjikan dengan pangsa pasar yang cukup tinggi. Penelitian ini bertujuan untuk mengetahui saluran pemasaran rumput laut jenis Eucheuma cottonii di Sumba Timur Provinsi Nusa Tenggara Timur. Data dan informasi dikumpulkan melalui observasi lapangan dan wawancara mendalam dengan pembudidaya serta dengan pengumpulan data sekunder. Data dianalisis secara kualitatif serta diuraikan dalam bentuk deskriptif dengan memberikan informasi mengenai saluran pemasaran rumput laut jenis Eucheuma cottonii di Sumba Timur. Hasil penelitian menunjukkan bahwa saluran pemasaran rumput laut di Sumba Timur dapat ditentukan oleh sumber permodalan yang berasal dari modal pribadi dan koperasi sehingga pemasaran tidak dipengaruhi oleh pedagang atau tengkulak. Kemudian dari sisi serapan dan pemasaran sumput laut dapat ditentukan oleh jenis produksi rumput laut yang terdiri dari raw material dan chips rumput laut. Raw material akan diserap oleh pedagang rumput laut lokal, pedagang rumput laut luar daerah Sumba Timur dan PT ASTIL. PT ASTIL akan mengolah rumput laut menjadi chips yang kemudian diserap oleh pembeli yang ada di Maassar, Surabaya dan Jakarta.Title: ABSTRACTEast Nusa Tenggara is the second largest producer after South Sulawesi in the production of Eucheuma cottonii. Therefore, the opportunity to develop Euchema cottonii seaweed is very promising with a high market share. This study aims to determine the marketing distribution of Eucheuma cottonii in East Sumba, East Nusa Tenggara Province. Data and information were collected through field observations and in-depth interviews with farmers as well as with secondary data collection. The data were analyzed qualitatively and described in descriptive form by providing information about the marketing distribution of Eucheuma cottonii in East Sumba. The results showed that the marketing distribution for seaweed in East Sumba could be determined by capital sources that originating from private capital and cooperatives so that marketing was not influenced by traders or middlemen. Furthermore the absorption and marketing of seaweed can be determined by the type of seaweed production consisting of raw material and seaweed chips. Raw material will be absorbed by local seaweed traders, seaweed traders in outside East Sumba and PT ASTIL. PT ASTIL will process seaweed into chips which are then absorbed by buyers in Makassar, Surabaya and Jakarta.
Relationship between evaluation of the teaching environment using DREEM scores and students’ school learning scores
Authors: Ikeda Yukihiro , Kubota Yoshie , Hiraide Atsushi
Published: January 2019

This article was migrated. The article was marked as recommended. The results from a comprehensive survey of students' perceptions of their educational environment using the Dundee Ready Educational Environment Measure (DREEM) in our Medical School were compared with students' school learning scores. The subjects (n=495) were medical students beyond their first year of medical school. The students were asked to read each DREEM statement carefully and respond using a 5-point Likert-type scale, with responses ranging from strongly agree to strongly disagree. The mean total DREEM score was 113.4, and there was no significant difference among total DREEM scores for students in different school years. Sixth-year students scored significantly higher than those in the second year for the Academic Self-Perception and Social Self-Perception domains. Females had higher school learning scores and also had better total and Perception of Course Organizers DREEM scores. The DREEM score tended to be lower for those with lower school learning scores, with significant differences found for total, Academic Self-Perception and Social Self-Perception scores. This is the first study to use the DREEM score for Japanese medical students, and further prospective research is required to obtain a complete understanding of the results.
An Analysis on the Institutionalization Process of a Home-Sharing Business in Japan: Application of Political Systems-Policy Network Theory
Authors:   The Tourism Sciences Society Of Korea, Atsuko Yasumoto , Lee Youn Taek
Published: January 2019

This study aimed at analyzing the institutionalization process of a home-sharing business in Japan by applying political systems-policy network theory. The literature review covered the concepts of home-sharing business, political systems-policy network theory, and the related precedent studies. For the research design, a conceptual model was proposed. Case study method was employed and the time scope of the research was established from June 2015 to June 2017. The major findings of this study revealed that the institutionalization process of the home-sharing business in Japan was affected by the political environment, the technological environment, the international environment, and the tourism market environment. The policy community model was formed by diverse official and non-official political actors. Finally, for policy output, an independent law was enacted. Based on these findings, theoretical implications for the research of the institutionalization process of the home-sharing business and the importance of forming a policy network in the institutionalization process are discussed.