bluuebunny/crossref_metadata_2025 huggingface dataset:
Recurrent hydrothorax associated with peritoneal dialysis: challenges in the diagnosis of pleuroperitoneal leak
Authors: Muralidhara Krithika , Dhareshwar Shashank , Nagesh Vinod , Marisiddappa Limesh , Kedelaya Prashanth , Satish Renuka
Published: May 2021

Background:

Peritoneal dialysis can be associated with various mechanical complications. Among them, pleuroperitoneal leak leading to recurrent hydrothorax is a lesser known entity. The condition can lead to life-threatening complications like respiratory distress, cardiac failure, arrhythmias, and infections. Various imaging modalities like computerized tomography, magnetic resonance imaging, and nuclear scans have been used to establish the diagnosis of pleuroperitoneal leak.

Case Presentation:

An elderly gentleman with multiple co-morbidities on peritoneal dialysis presented with recurrent hydrothorax. After ruling out cardiac, infective, and neoplastic etiologies as causes for hydrothorax, the diagnosis of pleuroperitoneal leak was established using computerized tomography peritoneography. Despite temporarily interrupting peritoneal dialysis, our patient developed recurrent hydrothorax, thus requiring to be transferred to hemodialysis.

Conclusion:

A high index of clinical suspicion and choice of the imaging modality will help in the timely diagnosis of pleuroperitoneal leak and appropriate therapeutic intervention.
Katsaus seuran toimintaan talouden näkökulmasta
Authors: Kaiponen Pälvi , Luokkanen Sinikka
Published: May 2021

Suomen tieteellisen kirjastoseuran hallituksen kokousten yhtenä kestoaiheena viime kuukausien aikana on ollut talous. Toimenpiteitä heikentyneen talouden tasapainottamiseksi on jo tehty, ja tätä työtä jatketaan. Hallituksessa on käynnistetty keskustelu myös Signumin tulevaisuudesta eli siitä, missä muodossa lehti jatkaa toimintaansa tulevaisuudessa. Tähän keskusteluun kutsutaan myös jäsenistö mukaan kevään aikana.
Determinants of passenger loyalty for high speed rail system in Turkey
Authors: AKYILDIZ ALÇURA Güzin , ŞİMŞEK Gülhayat Gölbaşı , KUŞAKCI GÜNDOĞAR Sümeyye Şeyma , TANRIVERDİ Sami Cankat , GÜRSOY Mustafa
Published: May 2021

Satisfaction and loyalty of passengers is important for a public transportation system provider especially if a competition exists between service providers. The factors affecting passenger satisfaction and loyalty must be determined by managers, operators, and decision makers. In this study, 900 passengers using High Speed Rail System between two cities (Ankara and Eskişehir) in Turkey were asked to rate their perceptions about the service they get. Their ratings are analyzed in terms of effects of factors on satisfaction and loyalty. The factors taken into consideration are service quality dimensions (which have ten sub-criteria), trust, perceived value, involvement, image, satisfaction and loyalty. Structural equation modeling is used to examine the direct and indirect relationships between these factors. Image is found effective on almost all factors analyzed: Perceived value, Trust, Satisfaction, Involvement and Loyalty. According to results, two important dimensions of service quality among ten dimensions came forward as most effective on satisfaction: Reliability and Interaction quality of personnel, which is found effective also on trust, satisfaction and involvement. On loyalty, the effective factors are found as perceived value, involvement, satisfaction and image.
SARS-CoV-2 reinfection: Two cases from Ethiopia
Authors: Huluka Dawit Kebede , Gebray Nigussie , Abera Beka , Yilak Getinet , Sherman Charles B. , Wolday Dawit
Published: May 2021

Reinfection with SARS-CoV-2 has infrequently been reported in the literature and never from Ethiopia or Africa. We describe two individuals with documented recurrent COVID-19 disease admitted to Eka Kotebe Hospital, Addis Ababa, Ethiopia.
SUPERVISI AKADEMIK KEPALA SEKOLAH SEBAGAI UPAYA MENINGKATKAN KINERJA GURU SDN 004 TOAPAYA DALAM PEMBELAJARAN DI KELAS
Authors: Mardiani Rita
Published: May 2021

This study aimed at improving the performance of SDN 004 Toapaya teachers in classroom learning through academic supervision at the second semester of the 2019/2020 academic year. The research subjects were teachers of SDN 004 Toapaya. The research was conducted in two cycles; each cycle consisting of four stages, namely: Planning, Implementing, Observing and Reflecting. The performance indicator set was if the score was at least 12 (sufficiently active). In classroom learning, it can be said that the actions taken are successful.Aspects measured in the observation are class teacher enthusiasm, teacher interaction with school supervisors, teacher interaction in KKG, group cooperation, and activities in group discussions. In the analysis, it was found that there was an increase in the activity and competence of teachers who compiled lesson plans from cycle I to cycle II. The achievement of performance indicators was achieved in the second action. Thus, it can be assumed that thePrincipal's Academic Supervision is an Effort to Improve the Performance of SDN 004 Toapaya Teachers in Classroom Learning. It is recommended to other supervisors or researchers that this teacher’s improvement model is continued to be implemented on an ongoing basis.
MODEL PEMBELAJARAN KOOPERATIF TIPE EXAMPLE NON EXAMPLE TERHADAP MOTIVASI BELAJAR IPA SISWA SD
Authors: Julyanto Ya'
Published: May 2021

This research was motivated when the teacher delivered material tended to use conventional method (lectures) which resulted in students becoming bored. The models and strategies used in classroom learning to tend to be less attractive so that students' enthusiasm for learning decreases. As well as props/ media that are rarely used related to the material to be achieved so that students' motivation is less to participate in learning in thematic subjects, especiallyscience. This study aims to determine the effect of the example non example cooperative learning model on students' learning motivation in science subjects outside the body of plants and their function in Class IV SDN 06 Raut. This research uses Quasi experimental design or quasi experiment. While the design in this experimental study used the research design One group pre test and post test. And the method in this research is simple linear regression. Theresults of students' learning motivation in Science were obtained through analysis pretest and post test data, namely pretest (before) obtained an average of 53.95% while the post test data analysis (after) obtained an average of 56.3%. Based on the results of the study, it can be concluded that the use of the example non example cooperative learning model does not have an insignificant effect on the motivation to learn science in the material outside the body ofanimals and plants and its function in grade IV SDN 06 Raut.
KEMAMPUAN MAHASISWA MEMBACA TEKS ILMIAH PADA PROGRAM STUDI PENDIDIKAN BAHASA INDONESUA FKIP UNTAN PONTIANAK
Authors: Susilowati Endang
Published: May 2021

This study was aimed at obtaining a deep understanding of the students' ability to read scientific texts, the obstacles they face, and how to overcome students’ difficulties of the second semester of the Indonesian Language and Literature Education Study Program in 2020 of FKIP Untan Pontianak. The results of the students' ability to read scientific texts are used as teaching policies in an effort to motivate and increase students in reading scientific texts to make thembetter. The method used in this research was descriptive, a form of quantitative research. The data of this research ere the test results of the ability to read scientific texts regarding literal understanding, interpretation, evaluation, and understanding of appreciation. Sources of data in this study were students of the Indonesian Language and Literature Education Study Program, semester II of 2020, FKIP Untan Pontinak. Data collection tools were objective test questions on reading comprehension and content interpretation. The data analysis usedquantitative descriptive techniques. The validity of the data was done by checking the validity of the data and it was proven by the triangulation proposed by Robin and Meleong. The reliability of the ability to read scientific texts was determined by the reliability of the rating results. Based on the research results, it can be concluded that the students' ability to read scientific texts hadan average value of 74.46. This study covered 30 students. There were 22 students with good grades above 70. There are 8 students whose grades were below 70 or not good. The obstacles faced by students in reading scientific texts were students who were not accurate in answering questions 26.6%, who did not master the vocabulary of absorption elements 27%, who did not understand the meaning of words based on the context of written sentences 30%. Students who did not master the meaning of foreign loan words, 23%, were less able to interpret meanings and read evaluatively 27%. The solutions and suggestions given to overcome these obstacles were as follows: Students are trained to read comprehension critically, to look for difficult vocabulary elements of foreign language absorption, to explain their meaning and use them in the context of other sentences, to assess evaluative reading both in groups and individually.Students also need to take the initiative to learn on their own even though they are not assigned /supervised by lecturers.
PENGUASAAN KONSEP GEOMETRI PADA SISWA SMP KOTA PONTIANAK TAHUN 2020
Authors: Rustam Rustam
Published: May 2021

This research was motivated by several reasons: (1) there was a misconception of some elementary school geometry materials that were considered essential; (2) the form of evaluation given was dominantly objective/multiple choice; (3) teachers' teaching methods tend not to be contextual; and (4) students' way of thinking simply to take the practical one. Through this research, it is expected to obtain information about: geometrical reasoning in elementary schools according to Bruner's theory, problem solving and mathematical representations. Theresearch was conducted in a descriptive analytic form, with the following steps: (1) giving questions for the geometry reasoning test for SMP; (2) analyzing answers according to the criteria of reasoning; and (3) mapping students' answers to the results of the analysis according to the profile criteria. The data obtained were analyzed, and the results were described to illustrate the condition of the geometric reasoning abilities of elementary school students. Theresults obtained in this study were: (1) The Mastery of the concept of geometry in each junior high school/equivalent. The target with the acquisition of an average score from all schools was 55, which was quite low because there were some students who did not master the concept of geometry and there were other mathematical concepts related to solving test questions; (2) There was no significant difference in the mastery of geometry concepts for male or femalestudents for each SMP/equivalent target, except for one school, namely SMP Negeri 17, which was because males are superior to females in three questions with a difference in the percentage of numbers of significantly correct; (3) The mastery of geometry concepts in each junior high school. The target of studying each geometry material was considered good, except for question number 1 with the subject of the Pythagorean Theorem, because students were dominant in not being able to use the relationship between concepts, especially the operation ofthe compounding form and the roots.
Down-Regulation of Nogo-A and PirB in Ischemic Cortex with Remote Ischemic Preconditioning in Mice
Authors:   Departments of Neurology, The Second Affiliated Hospital of Zhengzhou University, China, Y Jiao , J Wang ,   Departments of Neurology, The Second Affiliated Hospital of Zhengzhou University, China
Published: May 2021

Objectives: The present study aims to investigate the effect of Limb Remote Ischemic Preconditioning (LRIP) on the expression of Nogo-A and PirB in the cortex of mice with focal cerebral ischemia, and related pathways involving in axonal regeneration and neurological function recovery after cerebral ischemia. Methods: Adult male C57/BL6 mice were divided into sham-operated (sham), transient Middle Cerebral Artery Occlusion (MCAO), LRIP and anti- PirBAb treatment group. Samples were collected 48h after cerebral ischemia. The histopathologic changes were assessed by 1,3,5-Triphenyl-2H-Tetrazolium Chloride (TTC), and Hematoxylin and Eosin (HE) staining and TUNEL method. The expression of Nogo-A and PirB were determined by immunofluorescence, RT-PCR and Western blot respectively. Results: TTC staining showed that LRIP treatment reduced the infarct size of mice and anti-PirBAb treatment further decline the infarct size, which was accompanied with the decline of neurological deficit score and reduction of neuronal damage. LRIP treatment also reduced the TUNEL positive cells induced by MCAO and anti-PirBAb treatment further strengthened the effect of LRIP. Except sham group, the expressions of Nogo-A and PirB in other three groups all increased with varying degrees, among which MCAO group was the highest, LRIP group was the second and the anti-PirBAb group was the lowest. The expressions of growth associated protein 43 (GAP43) showed opposite tendency. Conclusions: LRIP plays beneficial influence on cerebral ischemia. LRIP and PirB inhibition combination has a better protective effect on nervous system after cerebral ischemia in mice.
Molecular Characterization and Antibiogram Profiling of Multidrug Resistant Staphylococcus haemolyticus Isolated from Patients with Urinary Tract Infection in Bangladesh
Authors:   Department of Veterinary and Animal Sciences, Faculty of Agriculture, Rajshahi University, Rajshahi-6205, Bangladesh, MH Haque , ML Miah ,   Department of Veterinary and Animal Sciences, Faculty of Agriculture, Rajshahi University, Rajshahi-6205, Bangladesh, S Sarker ,   Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University, Melbourne VIC 3086, Australia, M Shamsuzzaman ,   Specialty doctor in Acute Medicine, Leighton Hospital, Middlewich Rd, United Kingdom, MJA Shiddiky ,   School of Environment and Science (ESC), and Queensland Micro- and Nanotechnology Centre (QMNC) Griffith University, Nathan Campus, 170 Kessels Road, QLD 4111, Australia
Published: May 2021

The emergence of antibiotic-resistant bacteria in human is a potential global public health concern. Profiling of antibiotic-resistant bacteria with their antimicrobial susceptibility patterns from Urinary Tract Infections (UTIs) is crucial to guide antibiotic therapy. Herein we report a detailed bacteriological and molecular analysis of Staphylococcus haemolyticus and their antibiogram typing from UTIs. A total of 100 human urine samples of patients with UTIs were collected between January and December 2019 and were subjected to the conventional characterization of bacteria using the standard protocol. Molecular characterization was performed via sequencing followed by phylogenetic analysis. All bacterial strains were examined against thirteen commonly used antibiotics for susceptibility using the Kirby-Bauer disk diffusion method. The overall prevalence of S. haemolyticus in UTI was 26% with female patients having a higher prevalence of UTI (21 out of 26 or 80.76%) than male patients (5 out of 26 or 19.24%). The isolated S. haemolyticus showed 100%, 100%, 88.46%%, 76.93%, 73.08% and 65.39% resistant to penicillin, ampicillin, amoxicillin, erythromycin, ciprofloxacin and tetracycline, respectively. Importantly, S. haemolyticus demonstrated the highest sensitivity to vancomycin (100%), followed by azithromycin (80.76%), amikacin (84.61%), gentamycin (69.23%), levofloxacin (73.08%), ceftriaxone (80.76%) and doxycycline (61.54%). Overall, six variations were noted in S. haemolyticus in which most (5/6) modifications were substitutions and one (1/6) was deletion. These findings imply that mutations in the 16S rRNA gene sequence are the dominant source for species identification and variation in the drug sensitivity pattern against the S. haemolyticus. Phylogenetic analysis of the resultant 16S rRNA indicated that the isolated S. haemolyticus in this study belonged to genus Staphylococcus, but was different from the rest of the available S. haemolyticus isolates in other countries. Multidrug-resistant pathogenic S. hemolyticus is commonly found in urine samples of UTI in human in Bangladesh, which warrants a one-health approach for controlling this emerging ailment.
Candida albicans Activation of Human Monocytes Toward M2 Profile is Reversed by Amphotericin B and Fluconazole
Authors:   Department of Clinical Biochemistry, National University of Cordoba, Argentina, PA Icely , C Vigezzi ,   Department of Clinical Biochemistry, National University of Cordoba, Argentina, E Rodriguez ,   Department of Clinical Biochemistry, National University of Cordoba, Argentina, MS Miró ,   Department of Clinical Biochemistry, National University of Cordoba, Argentina, Renteria B Salido ,   Department of Clinical Biochemistry, National University of Cordoba, Argentina, CE Sotomayor ,   Department of Clinical Biochemistry, National University of Cordoba, Argentina
Published: May 2021

Phagocytes, including monocytes/macrophages, play an important role in the host defense during Candida albicans infections. In the L-arginine metabolism, the balance between the activation of two enzymes, inducible Nitric Oxide Synthase (iNOS) and arginase, promotes in the macrophages two alternative metabolic states, while M1 profile is related with host protection, M2 favored the fungal growth and evasion. Our aim was to evaluate the effect of Amphotericin B (AMB) and Fluconazole (FLC) on polarization of human monocytes to M2 profile induced by C. albicans. The human monocytic (Mo) cell line U937 was co-cultured with viable yeast of C. albicans, or Lipopolysaccharides (LPS) or Phorbol-12-myristate-13-acetate (PMA). Nitric Oxide (NO), cytokines production and arginase activity were evaluated. The effect of AMB or FLC on these metabolic pathways in immune cells and on fungus intrinsic arginase activity was studied. C. albicans inhibits NO production in human-monocyte and induces strong host arginase activity (p<0.0001). AMB and FLC inhibited C. albicansinduced arginase activity in immune cells (p<0.001), reaching a percentage of inhibition of 90% for AMB and 78% for FLC. Arginase intrinsic activity of the fungus was blocked by nor-NOHA (arginase inhibitor) and AMB (p<0.05). These results show that C. albicans drives human Mo toward M2 profile and that both antifungal drugs evaluated have the ability to revert C. albicans-induced M2 profile. In a relevant manner, it also provides data about additional effect of AMB as inhibitor of C. albicans endogenous arginase activity. Here in we provide new evidence for the effect of these drugs over the immune cells and the yeast.
Chemical Composition, Toxicological, Ethno-Medicinal and Pharmacological Reports of Annona senegalensis: A Review
Authors:   Department of Chemistry, Federal University of Technology Minna, Nigeria, SB Babalola , YH Adebiyi ,   Department of Biochemistry, Federal University of Technology Minna, Nigeria, A Lawal ,   Department of Chemistry, University of Ilorin, Nigeria, J Ajiboye ,   Department of Animal Biology, Federal University of Technology Minna, Nigeria, EB Berinyuy ,   Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon
Published: May 2021

Annona senegalensis is a traditional medicinal plant commonly used in traditional medicine for the treatment of various diseases. It belongs to a family of Annonaceae and commonly known by the name of Wild Custard Apple and Wild Soursop, etc. It is a shrub or small tree 2-6 m tall but may reach 11m under favorable conditions. It is widely spread throughout tropics and sub-tropics. It is commonly used for therapeutic fighting of major diseases including dysentery, diabetes mellitus, heart stroke, epilepsy, parasite and worm infestations, constipation, hemorrhage, dysuria, fever, ulcer, and cancers. The plant has also been reported for several biological activities including anti-oxidant, antidiarrheal, antimicrobial, antiparasitic, anticonvulsant, antitrypanosomal, antimalarial, anti-inflammatory, anti-snake venom, and antinociceptive properties. In order to provide sufficient baseline information for future works and commercial exploitation, this review represents the ethnomedicinal properties, phytochemicals composition, pharmacological properties, and safety/toxicity profile of A. senegalensis.
Use of Chlorhexidine to Eradicate Oropharyngeal SARSCoV-2 in COVID-19 Patients
Authors:   University of Southern California, Keck School of Medicine, USA, YH Huang , JT Huang ,   Division of Infectious Diseases, Good Samaritan Hospital, USA
Published: May 2021

Objective: As public distribution of a vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is in underway, prevention of coronavirus disease 2019 (COVID-19) relies on minimizing spread. In this study, chlorhexidine gluconate was investigated as a topical antimicrobial agent against SARS-CoV-2. Methods: This was a randomized, prospective cohort study using chlorhexidine as an oral rinse and posterior oropharyngeal spray in hospitalized COVID-19 patients. The primary outcome was presence or absence of laboratory-confirmed SARS-CoV-2 in the oral and oropharyngeal cavities after four days of chlorhexidine use and standard of care (study group) or standard of care only (control group). Results: SARS-CoV-2 was eliminated from the oropharynx in 62.1% of patients who used chlorhexidine as an oral rinse, versus 5.5% of the control group patients. In patients who used a combination of oral rinse and oropharyngeal spray, 86.0% eliminated oropharyngeal SARS-CoV-2, versus 6.3% of control patients. Conclusions: Chlorhexidine is a simple and safe addition to current COVID-19 prevention guidelines and may play a significant role in reducing disease spread.
Assessing Locomotor Coordination during Walking and Running in Children and Adolescents: A Systematic Review
Authors:   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium, M Goetschalckx , L Moumdjian ,   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium, K Klingels ,   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium,   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium, P Feys ,   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium, E Rameckers ,   REVAL Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium
Published: May 2021

We aimed to systematically summarize assessment methods of locomotion coordination of the lower limbs in children, and to discuss the influence of person and task on locomotor coordination. Two databases (PubMed, Web of Science) were screened, up to April 1th 2020. Five articles were included. Locomotor coordination was assessed in Typically Developing Children (TD) and children with autism in different domains of coordination, using angle-angle plots, planar covariance, continuous relative phase and point-phasing. In TD children: age influenced intersegmental covariance when walking, and stability of temporal and amplitude phasing when running. Intersegmental covariance was influenced by vision and walking speed. Phase relationship was not influenced by weighted walking in autistic children, nor in TD children when walking backwards.
Building Machine Learning Force Fields of Proteins with Fragment-Based Approach and Transfer Learning
Authors: Cheng Zheng , Du Jiahui , Zhang Lei , Ma Jing , Li Wei , Li Shuhua
Published: May 2021

Molecular dynamic (MD) simulation plays an essential role in understanding protein functions at atomic level. At present, MD simulations on proteins are mainly based on classical force fields. However, the accuracy of classical force fields for proteins is still insufficient for accurate descriptions of their structures and dynamical properties. Here we present a novel protocol to construct machine learning force field (MLFF) for a given protein with full quantum mechanics (QM) accuracy. In this protocol, the energy of the target system is obtained by fitting energies of its various subsystems constructed with the generalized energy-based fragmentation (GEBF) approach. To facilitate the construction of MLFF for various proteins, a protein’s data library is created to store all data of subsystems generated from trained proteins. With this protein’s data library, for a new protein only its subsystems with new topological types are required for the construction of the corresponding MLFF. This protocol is illustrated with two polypeptides, 4ZNN and 1XQ8 segment, as examples. The energies and forces predicted from this MLFF are in good agreement with those from density functional theory calculations, and dihedral angle distributions from GEBF-MLFF MD simulations can also well reproduce those from ab initio MD simulations. Therefore, this GEBF-ML protocol is expected to be an efficient and systematic way to build force fields for proteins and other biological systems with QM accuracy.
Cyclohexanohemicucurbit[8]uril forms inclusion complexes with heterocycles and removes sulfuric guests from water via solid-phase extraction
Authors: Shalima Tatsiana , Mishra Kamini A. , Kaabel Sandra , Ustrnul Lukas , Bartkova Simona , Tõnsuaadu Kaia , Heinmaa Ivo , Aav Riina
Published: May 2021

We found that cyclohexanohemicucurbit[8]uril encapsulates five- and six-membered sulfur- and oxygen-containing unsubstituted heterocycles and can be used as a selective sorption material for the extraction of sulfur-heterocycles like 1,3-dithiolane and α‑lipoic acid from water.
Operation Mechanism of Organic Electrochemical Transistors as Redox Chemical Transducers
Authors: Tan Siew Ting Melissa , Keene Scott Tom , Giovannitti Alexander , Melianas Armantas , Moser Maximilian , McCulloch Iain , Salleo Alberto
Published: May 2021

There is intense interest in utilizing the redox activity of Organic Mixed Ionic Electronic Conductors for faradaic chemical sensing. In particular, the investigation of organic electrochemical transistors (OECTs) as biosensors due to their low operational potentials, ease of fabrication (e.g. by inkjet printing), biocompatibility, and large transconductance. It has become common practice in the OECT community to combine both chemical detection and transistor function within the same compartment, assuming that the sensor signal is amplified seamlessly by the sensing OECT. These devices however routinely encounter several challenges whose origins often remained unclear. Some of these challenges are 1) small changes in drain current, contradicting OECT’s oft-touted current-amplifying abilities. 2) Irreversible chemical changes to the semiconducting polymer electrodes. 3) Parasitic side reactions convoluting the sensing signal, exacerbated by applied voltages. In this manuscript, we show that optimization of OECT-based sensors requires more rigorous characterization of electrode potentials to elucidate electrochemical phenomena, a practice that is often largely absent in current reports. Our analysis of fundamental device physics of various OECT architectures shows that despite what a large fraction of the organic bioelectronics community still believes, amperometric OECTs either 1) do not display any transistor behavior, and in fact operate merely as electrodes or 2) Undergo irreversible changes and are extremely complex to calibrate, or both 1) and 2). Indeed, to fully utilize the OECT’s large transconductance, a separate 2-electrode Reaction Cell which is utilized to gate a separate OECT is needed (RC-OECT). In this manuscript, in addition to showing that the RC-OECT resolves the fundamentally and irreconcilably contradicting design principles of amperometric OECTs, we demonstrate that it provides great device and materials design flexibility. Finally, we elucidate the basic principles on how to further optimize the RC-OECT. We believe that our findings will be of great interest to researchers in the fields of bioelectronics as a call to action to re-evaluate present approaches of utilizing OECTs for chemical detection and to help practitioners select materials and designs to optimize redox sensors based on organic semiconductors.
Green Investment: Incorporate Environment, Social, And Government Factors In Investment Decision
Authors: Cakranegara Pandu Adi , Sidjabat Filson Maratur
Published: May 2021

There are two types of investors, the first is the type of investor who focuses on return on investment and the second type is the investor who pays attention to Environmental, Social, and Governance (ESG) values in investing. This requires management to make adjustments to create a competitive advantage. One of the frameworks used to measure the competitive advantage of a company is the Porter framework. However, Porter's framework needs to be supplemented with ESG values to capture the value creation process in today's business environment. This research is applied research by applying the existing framework in the field. In this case, the framework used consists of two, namely the Porter framework and the LST integration framework. The ESG framework is implemented at the industrial level using industrial divisions based on industrial divisions in the Indonesia Stock Exchange. This study focused on the raw material production sector, namely agriculture, and mining. This study showed that ESG factors affected the competitive advantage of companies and industries. If a company in an industry ignores the value of ESG, the company will experience a decrease in competitiveness. Meanwhile, if the industry does not pay attention to the ESG factor, the industry will experience a decline compared to other industries that pay attention to the ESG factor.
A Clustering Analysis Method for Massive Music Data
Authors: Xu Yanping , Xu Sen
Published: May 2021

Clustering analysis plays a very important role in the field of data mining, image segmentation and pattern recognition. The method of cluster analysis is introduced to analyze NetEYun music data. In addition, different types of music data are clustered to find the commonness among the same kind of music. A music data-oriented clustering analysis method is proposed: Firstly, the audio beat period is calculated by reading the audio file data, and the emotional features of the audio are extracted; Secondly, the audio beat period is calculated by Fourier transform. Finally, a clustering algorithm is designed to obtain the clustering results of music data.
Peran Negara dalam Mengurangi Ketimpangan Digital: Studi Kasus Afrika Selatan
Authors: Puspitaningrum Lusi
Published: May 2021

Tulisan ini ini membahas mengenai ketimpangan digital yang terjadi di negara Afrika Selatan sebagai negara dengan tingkat ketimpangan terendah diantara negara-negara kawasannya. Tulisan ini dibuat untuk melihat apa saja peran negara yang menyebabkan angka ketimpangan digital di negara Afrika Selatan tidak begitu tinggi. Penulisa menggunakan konsep digital divide guna memahami kondisi ketimpangan digital yang terjadi di Afrika Selatan. Sementara itu dalam penulis juga menggunakan konsep developmental state untuk menganalisis peran negara dalam mengatasi ketimpangan menggunakan metode kualitatif dengan dokumen-dokumen kebijakan sebagai sumber data. Meskipun peristiwa historis masa lampau masih dirasa kuat oleh masyarakat negara Afrika Sellatan, namun tidak menjadi penghambat bagi kemajuan Afrika Selatan. Dalam mencapai posisinya saat ini, negara Afrika Selatan telah berupaya membuat kebijakan-kebijakan untuk mendukung peningkatan penetrasi digital dalam rangka mengurangi ketimpangan di negaranya. Negara berperan dalam mendorong pembangunan infrastruktur, pendidikan, serta membangun kerjasama dengan aktor lainnya seperti sektor privat, institusi poendidikan, hingga organisasi innternasional guna mengatasi ketimpangan digital di Afrika Selatan.
Defensive Realism’s Perspective on Rising China’s Behavior as A Status Quo State
Authors: Jyalita Vincentia Vahistha Hirrya
Published: May 2021

China’s rise through rapid development especially in the economic sector have prompted debates on whether it seeks to overtake the United States (U.S.) and strive for domination. However, China insists that it has no such intentions since it benefits from the current system and wishes to pursue peaceful development. This paper will analyze why China is not seeking to displace the U.S. and alter the international order despite claims from offensive realism that states are revisionist as they pursue domination to guarantee its survival under anarchy. This paper argues that defensive realism can better explain the case and that China is a status quo state unlike claims from offensive realism. The writer conducted the study with defensive realism’s perspective and utilized indicators from Steve Chan, Weixing Hu, and Kai He to determine whether China is a status quo state. The results show that defensive realism can fill the gap left by offensive realism and that China is indeed a status quo state. Kebangkitan China yang ditandai dengan perkembangan pesat, terutama dalam bidang ekonomi, telah memicu perdebatan tentang apakah China berusaha untuk mengambil alih kekuasaan Amerika Serikat (A.S.) dan mendominasi tatanan global. Namun, China bersikeras dalam mengklaim bahwa tidak ada niat seperti itu karena mendapatkan keuntungan dari sistem saat ini dan lebih ingin mengejar pembangunan secara damai. Artikel ini akan menganalisis mengapa China tidak berusaha untuk menggantikan A.S. maupun mengubah tatanan global, meskipun ada klaim dari offensive realism bahwa setiap negara adalah revisionist karena mereka memperluas kekuasaannya untuk menjamin kelangsungan hidupnya di bawah sistem dunia yang anarki. Dalam artikel ini, penulis berpendapat bahwa defensive realism dapat menjelaskan kasus ini dengan lebih baik dan China adalah negara status quo tidak seperti klaim dari offensive realism. Penulis melakukan studi dengan perspektif defensive realism dan menggunakan indikator dari Steve Chan, Weixing Hu, dan Kai He untuk menentukan apakah China merupakan negara status quo. Hasilnya menunjukkan bahwa defensive realism dapat mengisi kekosongan yang ditinggalkan oleh offensive realism dan bahwa China memang negara status quo.
NATO in The Very Cold War: Why the US Needs Nato in the Arctic
Authors: Effendy Sharon Sebastian , Franchika Bernadeth , Kusuma Vanessa Anthea
Published: May 2021

Global warming and climate change resulting in the melting of sea ice within the Arctic have subsequently opened the possibility to explore and exploit the region. Previously seen as simply a region full of ice, the Arctic is believed to possess abundant natural resources, with an estimated 13% of undiscovered oil, 30% of natural gas resources in the world, as well as the opening of a new sea route which will be able to serve as a shortcut for countries to exchange goods - attracting states to pay closer attention to the region, be it militarily, politically, or economically, the United States being one of them. The increase in presence and power among Arctic and non-Arctic countries, especially Russia and China, has inarguably created a state of security dilemma among all parties involved, which is why if the US would like to seek a larger presence within the region, it becomes important for the country to involve NATO as one of its key partners, despite issues concerning the country and the organization. For the purpose of this paper, the aforementioned argument will further be supported using concepts of security dilemma, hegemonic stability theory, and the balance of threat.
Investigation Report on Preschool Education Specialty of Higher Vocational School——Take the Preschool Education Market of HengYang City as an Example
Authors: Yuan Wenfang
Published: May 2021

Accurate understanding of the demand for talents in higher vocational preschool education majors under the background of the integration of industry and education is helpful to provide a practical theoretical basis for the formulation of five-year preschool education specialty direction and teaching standards. Through questionnaire survey, field interview, literature review and other ways to vocational colleges, kindergartens, preschool field related employers to carry out real-time research. Through the investigation, it is found that the number of graduates majoring in three-year preschool education can not meet the demand of the local market, and the flow of graduates is the key factor that directly leads to the market "short supply". In addition, there are other problems in the demand situation. Combined with the investigation and analysis, measures such as establishing the five-year preschool education major, optimizing the core curriculum system, and strengthening the long-term mechanism of school-enterprise cooperation are proposed.
Study on the Taste-oriented Design of Ceramic Doll in Foshan City
Authors: Huang Huanchen
Published: May 2021

Foshan city of Guangdong province, who enjoys the reputation of Ceramics’ Capital in South China is one of the largest and most important ceramic production bases in China. Foshan ceramic works of art have a long history and have a great influence in the whole country. In this paper, we try to change the design of the simple historical figure, zodiac animal image and vase purely for daily necessities. To enrich the theoretical results of Foshan ceramic doll art research, Foshan ceramic doll insists taste-oriented design so as to further strengthen the research of interesting design, better adapt to the psychological needs of the audience, create the popular literary and artistic works, lead to the improvement of people’s consuming taste, and finally promote the construction of social spiritual civilization and the development of cultural industry in Foshan.
PENINGKATAN KEMAMPUAN ANGGOTA KOMUNITAS MASYARAKAT PEDULI TB (KMP-TB) DALAM PROGRAM PENANGGULANGAN TB BERBASIS MASYARAKAT
Authors: Yuniar Isma , Sarwono Sarwono , Widiastuti Tri Cahyani
Published: May 2021

Penyakit Tuberkulosis (TB) atau biasa disebut TBC menjadi penyakit menular paru-paru yang paling berbahaya di tahun 2016. TB merupakan penyebab kematian utama di banyak negara berkembang. Kegiatan penemuan kasus Tuberkulosis Paru dilakukan selain dengan pasif case finding, juga dengan melibatkan kader kesehatan  dalam pelaksanaan kegiatan program Tuberkulosis Paru . Kurang optimalnya peran kader dan petugas kesehatan menjadi faktor penyebab kegagalan penanggulangan TB.  Angka penemuan TB mengalami penuruan, belum sesuai dengan target yang ditentukan. Succes rate di Kabupaten Kebumen berdasarkan data yang diperoleh pada tiga tahun terakhir juga masih di bawah standar yang ditetapkan.  Solusi yang ditawarkan oleh Tim Pengabdian masyarakat Stikes Muhammadiyah Gombong adalah membeningkatkan peran KMP-TB dalam hal penanggulangan TB dengan melalui beberapa kegiatan, yaitu memberikan pelatihan dasar (pelatihan tentang komunikasi dasar, konseling dan pelatihan teknik penyuluhan), Pelatihan Inti tentang TB dan penangobatannya, simulasi (simulasi deteksi dini TB dan simulasi pemberian obat TB). Hasil dari kegiatan ini menunjukkan adanya penigkatan pengetahuan anggota KMP-TB Puring tentang komunikasi, promosi kesehtan, penyakit TB dan pengobatan
EDUKASI DAMPAK NEGATIF BERMAIN GAME ONLINE DAN TONTONAN KEKERASAN PADA SISWA SMP MUHAMMADIYAH GOMBONG
Authors: Sumarsih Tri , Nugroho Fajar Agung
Published: May 2021

Abstrak Latar belakang: Saat ini, banyaknya tayangan di media, khususnya televisi dan berbagai game online yang kurang mendidik dan berdampak negatif bagi anak. Upaya yang dilakukan melaluii upaya promotif dan preventif yaitu dengan memberikan edukasi, berdiskusi (peergroup) terkait dampak negatif bermain game online dan tontonan yang bermuatan kekerasan. Sedangkan, upaya kuratif dan rehabilitatif dilakukan bagi siswa siswi yang membutuhkan perhatian khusus dan sudah mengalami kecanduan berat dengan melibatkan pihak guru dan orangtua siswa. Tujuan: Meningkatkan pemahaman dan perubahan perilaku siswa siswi SMP Muhammadiyah Gombong melalui edukasi dampak negatif bermain game online dan tontonan bermuatan kekerasan. Metode: Memberikan penyuluhan kepada siswa-siswi SMP Muhammadiyah Gombong sebanyak 50 responden yang sudah dilakukan screening dan termasuk dalam kategori sering, kecanduan game oline serta tontonan bermuatan kekerasan. Pelaksanaan kegiatan ini dilakukan 2 kali, kegiatan pertama memberikan edukasi kepada siswa-siswi dengan melibatkan Psikolog remaja, kegiatan kedua memberikan edukasi kepada orangtua/wali siswa. Selanjutnya menyepakati rencana tindak lanjut dengan para orang tua/wali siswa. Hasil: Sebagian besar partisipan berjenis kelamin laki-laki sebanyak 47 (94%) dan berusia 12 tahun sebanyak 17 (34%). Rerata lama waktu bermain game online yaitu 5.79 jam. Mayoritas rerata hari per minggu dalam bermain game online yaitu 2-3 hari/minggu, sedangkan mayoritas rerata jam per hari dalam bermain game online yaitu >2-3 jam. Sebagian besar pengeluaran biaya internet dalam satu minggu yaitu tidak ada biaya sebanyak 21 siswa (42%) dan menunjukkan hasil yang sama dengan pengeluaran biaya internet dalam satu bulan yaitu tidak ada biaya sebanyak 20 siswa (40%). Simpulan: pemahaman siswa-siswi terhadap dampak negatif bermain game online dan tayangan bermuatan kekerasan mengalami peningkatan sebesar 62%.Keyword:edukasi; game online; tontonan kekerasan
PENINGKATAN PENGETAHUAN DAN KETRAMPILAN KONSELING MENYUSUI MELALUI PELATIHAN MENGGUNAKAN MEDIA DUKESI (MODUL PAKET ASI)
Authors: Ani Murti , Astuti Anjar , Harwijayanti Bekti Putri , Ristiana Ristiana
Published: May 2021

Breastfeeding is very beneficial for babies, mothers and families. However, not all mothers provide breastfeeding exclusively to their babies, because there are very limited breastfeeding counselors and the low availability of educational facilities and infrastructure on breastfeeding. The solution offered is to provide assistance and training to midwives who have not become breastfeeding counselors to be able to provide breastfeeding counseling using the Dukesi media (Breastfeeding Package Module). Dukesi is a module that makes it easier for mothers to get various information about breastfeeding. The training was attended by 26 midwives from 26 Primary Health Care in Blora District, conducted for 3 meetings. The first meeting was the pretest, delivering material on the role of health workers to increase exclusive breastfeeding coverage, use of health education media, material on the breastfeeding package module. The second meeting was providing material on breastfeeding counseling technique skills. The third meeting is the practice of breastfeeding counseling, posttest and evaluation. Based on the paired t-test, it was found that there was an effect of training using dukesi media on the knowledge level of 0.000 (<0.05) and there was an effect of training using dukesi media on breastfeeding counseling skills at 0.000 (<0.05). Keywords: breastfeeding; counseling; dukesi; module; training
PENERAPAN AKTIVITAS FUNGSIONAL REKREASI PADA MASA NEW NORMAL UNTUK MENJAGA KESEHATAN LANJUT USIA
Authors: Kardi Ipa Sari , Nasri Nasri , Ibrahim Ibrahim , Nopiyanto Yahya Eko
Published: May 2021

Background: Structural and functional change in the elderly is a process that cannot be stopped, but can be managed, so that it can inhibit the aging process. Technological advances in the digital era 4.0 coupled with the Covid-19 pandemic at the beginning of 2020 make someone, especially the elderly, less mobile. One of the actions that can be taken is implementing recreational functional activities, which are physical activities that are carried out happily with other people, such as family or community. This action is one of the safe and effective ways to help maintain the health of the elderly during the new normal period, so that the elderly are still able to carry out daily physical activities, stay healthy, productive and happy. Recreational functional activities play an important role in the well-being of the elderly and in improving the quality of life of all ages, including the elderly. Purpose: This community service aims to introduce a variety of functional activities that can entertain and delight the elderly. Methods: The method used was counseling and the application of recreational functional activities. Results: Based on the results of blood pressure examinations, it was found that the elderly who had hypertension were (73%) and normal (27%), the BMI measurement showed less weight (20%), normal weight (13%), over weight (20%) , OB I (27%) and OB II (20%). After applying recreational functional activities, there is a good response from the elderly. The elderly feel happier, experience and increase knowledge about simple movements that can stimulate the physical, psychological and social health of the elderly, even if only around the place of residence.
DANCE COMPETATION HAND HIGINE DESA BIJIRUYUNG KECAMATAN SEMPOR KEBUMEN
Authors: Marsito Marsito
Published: May 2021

Kegiatan lomba cuci tangan dengan sabunatau dance competation hand higene  yang dikemas dengan lomba cuci tangan dilakukan  dengan  melibatkan masyarakat dan ibu-ibu rumah tangga masih rendah. Selama pandemic covid 19 pencegahan dilakukan dengan melakukan cuci tangan. Di Indonesia kebiasaan melakukan cuci tangan dengan sambun masih 47%, (Kemenkes RI, 2014). Tujuan dilakukan lomba cuci tangan ini diharapkan  untuk meningkatkan perilaku cuci tangan pakai sabun yang ada di keluarga. Penerapan metode hand washing dance  terhadap pengetahuan tehnik mencuci tangan pada masyarakat merupkan metode yang baik untuk dilakukan.Peserta lompa cuci tangan sampai sabun di ambil tiap rukun tetangga dari tiap rukun warga Desa Bijiruyung.Hasil penilaian itu dilihat dari konstum kerapian baju, kekompakan satu kelompok, kreatifitas dan 7 langkah cuci tangan yang benar. Dari hasil didapatkan nilai rentang  dari  7,7 sampai dengan 8,7.. Sedangkan unsur penilaian lomba cuci tangan yang mendominasi dari unsur  kreatifitas peserta dengan nilai 8.6. Dapat disimpulkan bahwa dari sekian peserta warga sudah melakukan cuci tangan sudah benar dan sudah baik yang menambah nilai jumlah itu adalah variasi kreatifitas dari kegiatan cuci tangan. Seperti konstum baju dan mengangkat topik dari kegaitan ini.
IMPLEMENTASI GERAKAN SATU RUMAH SATU JUMANTIK (G1R1J) MEWUJUDKAN LINGKUNGAN BEBAS DEMAM BERDARAH DENGUE
Authors: Widiyanto Puguh , Widyantoro Tri , Ulva Syarifatul , Ningrum Meiliana Purnama , Safitri Nita Ana
Published: May 2021

Implementation of activities one house one larva monitors (G1R1J) is a community-based empowerment program for the eradication of mosquito nests to prevent the reproduction of the Aedes Agepty vector mosquito that causes Dengue Hemorrhagic Fever (DHF). The case fatality rate in the first semester of 2020 was ranked third in Central Java (6.67%), far exceeding the national standard of less than 2%. Although the incidence of dengue fever at the Mertoyudan Health Center has a tendency to decline in the first semester of 2020, entering the rainy season requires public vigilance for the emergence of dengue cases. Santan Village RT 06 RW 02, Sumberejo sub-district, the working area of Mertoyudan Health Center has 152 people with 47 family heads, inseparable from the importance of preventing DHF, being the target of community service by implementing G1R1J. The results obtained after the completion of the activity obtained increased knowledge, attitudes and behavior of the community.