bluuebunny/crossref_metadata_2025 huggingface dataset:
Fabrication of Nitrogen-Doped Graphene Quantum Dots-Cu2O Catalysts for Enhanced Photocatalytic Hydrogen Evolution
Authors: Wu Yilin , Yan Ming , Gao Jia , Lv Peng , Liu Xinlin , Li Chunxiang , Yan Yongsheng
Published: August 2018

Development of efficient visible light driven photocatalysts for water splitting has attracted great research interest. Herein, a novel H2-producing nitrogen-doped graphene quantum dots (NGQDs)-Cu2O was successfully constructed and synthesized. The as-prepared NGQDs-Cu2O photocatalysts were benefited for light harvesting and charge separation and showed highly efficient photocatalytic property for hydrogen production by water splitting. Results displayed that the amount of NGQDs exhibited significant influence for H2 production, and the optimum sample of 3%NGQDs-Cu2O performed the highest hydrogen-evolution rate of 22.6[Formula: see text][Formula: see text]mol h[Formula: see text] g[Formula: see text], which was about 2 times higher than that of the pure Cu2O (10.1[Formula: see text][Formula: see text]mol h[Formula: see text] g[Formula: see text]). By further study, the enhanced photocatalytic performance could be ascribed to the crucial role of NGQDs, which widely improve the separation of photogenerated electron-hole pair’s.
Spectral statistics of non-Hermitian random matrix ensembles
Authors: Chen Ryan C. , Kim Yujin H. , Lichtman Jared D. , Miller Steven J. , Sweitzer Shannon , Winsor Eric
Published: August 2018

Recently Burkhardt et al. introduced the [Formula: see text]-checkerboard random matrix ensembles, which have a split limiting behavior of the eigenvalues (in the limit all but [Formula: see text] of the eigenvalues are on the order of [Formula: see text] and converge to semi-circular behavior, with the remaining [Formula: see text] of size [Formula: see text] and converging to hollow Gaussian ensembles). We generalize their work to consider non-Hermitian ensembles with complex eigenvalues; instead of a blip new behavior is seen, ranging from multiple satellites to annular rings. These results are based on moment method techniques adapted to the complex plane as well as analysis of singular values.
Ethics of Archaeology
Authors: González-Ruibal Alfredo
Published: August 2018

Ethics has abandoned its niche status to become a shared concern across archaeology. The appraisal of the sociopolitical context of archaeological practice since the 1980s has forced the discipline to take issue with the expanding array of ethical questions raised by work with living people. Thus, the original foci on the archaeological record, conservation, and scientific standards, which are behind most deontological codes, have been largely transcended and even challenged. In this line, this review emphasizes philosophical and political aspects over practical ones and examines some pressing ethical concerns that are related to archaeology's greater involvement with contemporary communities, political controversies, and social demands; discussion includes ethical responses to the indigenous critique, the benefits and risks of applied archaeology, the responsibilities of archaeologists in conflict and postconflict situations, vernacular digging and collecting practices, development-led archaeology, heritage, and the ethics of things.
Climate Change and Phenological Mismatch in Trophic Interactions Among Plants, Insects, and Vertebrates
Authors: Renner Susanne S. , Zohner Constantin M.
Published: August 2018

Phenological mismatch results when interacting species change the timing of regularly repeated phases in their life cycles at different rates. We review whether this continuously ongoing phenomenon, also known as trophic asynchrony, is becoming more common under ongoing rapid climate change. In antagonistic trophic interactions, any mismatch will have negative impacts for only one of the species, whereas in mutualistic interactions, both partners are expected to suffer. Trophic mismatch is therefore expected to last for evolutionarily short periods, perhaps only a few seasons, adding to the difficulty of attributing it to climate change, which requires long-term data. So far, the prediction that diverging phenologies linked to climate change will cause mismatch is most clearly met in antagonistic interactions at high latitudes in the Artic. There is limited evidence of phenological mismatch in mutualistic interactions, possibly because of strong selection on mutualists to have co-adapted phenological strategies. The study of individual plasticity, population variation, and the genetic bases for phenological strategies is in its infancy. Recent work on woody plants revealed the large imprint of historic climate change on temperature, chilling, and day-length thresholds used by different species to synchronize their phenophases, which in the Northern Hemisphere has led to biogeographic phenological regions in which long-lived plants have adapted to particular interannual and intermillennial amplitudes of climate change.
Jefferson Lab at 12 GeV: The Science Program
Authors: Burkert Volker D.
Published: August 2018

Jefferson Lab's upgrade of its Continuous Electron Beam Accelerator Facility (CEBAF) has recently been completed. The project involved an upgrade of the accelerator to achieve a maximum beam energy of 12 GeV and the construction of a fourth end station, Experimental Hall D, as well as new detector equipment for two of the three existing halls (A, B, and C). A broad experimental program has been developed to map the nucleon's intrinsic quark distributions in transverse space and in longitudinal momentum through measurements of deeply exclusive and semi-inclusive processes, and to probe color confinement by studying the spectrum of hadrons with active gluon degrees of freedom in the wave function. Other programs include the forward parton distribution function at large quark momentum fraction x, the quark and gluon polarized distribution functions, measurements of electromagnetic form factors of the nucleon ground state and of nucleon resonance transitions at short distances, and the exploration of physics beyond the Standard Model in high-precision parity-violating processes and in the search for signals of dark matter. The higher beam energy is also suitable for exploration of quark hadronization properties using the nucleus as a laboratory. This review highlights major areas of hadron and nuclear science that will be the focus of the first 5 years of operation.
Randall’s plaque in stone formers originates in ascending thin limbs
Authors: Evan Andrew P. , Coe Fredric L. , Lingeman James , Bledsoe Sharon , Worcester Elaine M.
Published: August 2018

Randall’s plaque, an attachment site over which calcium oxalate stones form, begins in the basement membranes of thin limbs of the loop of Henle. The mechanism of its formation is unknown. Possibly, enhanced delivery of calcium out of the proximal tubule, found in many stone formers, increases reabsorption of calcium from the thick ascending limb into the interstitium around descending vasa recta, which convey that calcium into the deep medulla, and raises supersaturations near thin limbs (“vas washdown”). According to this hypothesis, plaque should form preferentially on ascending thin limbs, which do not reabsorb water. We stained serial sections of papillary biopsies from stone-forming patients for aquaporin 1 (which is found in the descending thin limb) and the kidney-specific chloride channel ClC-Ka (which is found in the ascending thin limb). Plaque (which is detected using Yasue stain) colocalized with ClC-Ka, but not with aquaporin 1 (χ2 = 464, P < 0.001). We conclude that plaque forms preferentially in the basement membranes of ascending thin limbs, fulfilling a critical prediction of the vas washdown theory of plaque pathogenesis. The clinical implication is that treatments such as a low-sodium diet or thiazide diuretics that raise proximal tubule calcium reabsorption may reduce formation of plaque as well as calcium kidney stones.
Antihyperglycemic agents as novel natriuretic therapies in diabetic kidney disease
Authors: León Jiménez David , Cherney David Z. I. , Bjornstad Petter , Castilla-Guerra Luis , Miramontes González José Pablo
Published: August 2018

While sodium-glucose cotransporter-2 (SGLT2) inhibitors have been used for the routine management of type 2 diabetes for several years, it is perhaps their natriuretic effects that are most important clinically. This natriuresis activates tubuloglomerular feedback, resulting in reduced glomerular hypertension and proteinuria, leading to renal protective effects in the EMPA-REG OUTCOME and CANVAS Program trials. In the cardiovascular system, it is likely that plasma volume contraction due to natriuresis in response to SGLT2 inhibition is at least in part responsible for the reduction in the risk of heart failure observed in these trials. We compare this mechanism of action with other antidiabetics. Importantly, other diuretic classes, including thiazide and loop diuretics, have not resulted in such robust clinical benefits in patients with type 2 diabetes, possibly because these older agents do not influence intraglomerular pressure directly. In contrast, SGLT2 inhibitors do have important physiological similarities with carbonic anhydrase inhibitors, which also act proximally, and have been shown to activate tubuloglomerular feedback.
Micropools of reliable area MT neurons explain rapid motion detection
Authors: Krause Bryan M. , Ghose Geoffrey M.
Published: August 2018

Many models of perceptually based decisions postulate that actions are initiated when accumulated sensory signals reach a threshold level of activity. These models have received considerable neurophysiological support from recordings of individual neurons while animals are engaged in motion discrimination tasks. These experiments have found that the activity of neurons in a particular visual area strongly associated with motion processing (MT), when pooled over hundreds of milliseconds, is sufficient to explain behavioral timing and performance. However, this level of pooling may be problematic for urgent perceptual decisions in which rapid detection dictates temporally precise integration. In this paper, we explore the physiological basis of one such task in which macaques detected brief (~70 ms) transients of coherent motion within ~240 ms. We find that a simple linear summation model based on realistic stimulus responses of as few as 40 correlated neurons can predict the reliability and timing of rapid motion detection. The model naturally reproduces a distinctive physiological relationship observed in rapid detection tasks in which the individual neurons with the most reliable stimulus responses are also the most predictive of impending behavioral choices. Remarkably, we observed this relationship across our simulated neuronal populations even when all neurons within the pool were weighted equally with respect to readout. These results demonstrate that small numbers of reliable sensory neurons can dominate perceptual judgments without any explicit reliability based weighting and are sufficient to explain the accuracy, latency, and temporal precision of rapid detection.

NEW & NOTEWORTHY Computational and psychophysical models suggest that performance in many perceptual tasks may be based on the preferential sampling of reliable neurons. Recent studies of MT neurons during rapid motion detection, in which only those neurons with the most reliable sensory responses were strongly predictive of the animals’ decisions, seemingly support this notion. Here we show that a simple threshold model without explicit reliability biases can explain both the behavioral accuracy and precision of these detections and the distribution of sensory- and choice-related signals across neurons.
Guts and Gall: Bile Acids in Regulation of Intestinal Epithelial Function in Health and Disease
Authors: Hegyi Peter , Maléth Jozsef , Walters Julian R. , Hofmann Alan F. , Keely Stephen J.
Published: August 2018

Epithelial cells line the entire surface of the gastrointestinal tract and its accessory organs where they primarily function in transporting digestive enzymes, nutrients, electrolytes, and fluid to and from the luminal contents. At the same time, epithelial cells are responsible for forming a physical and biochemical barrier that prevents the entry into the body of harmful agents, such as bacteria and their toxins. Dysregulation of epithelial transport and barrier function is associated with the pathogenesis of a number of conditions throughout the intestine, such as inflammatory bowel disease, chronic diarrhea, pancreatitis, reflux esophagitis, and cancer. Driven by discovery of specific receptors on intestinal epithelial cells, new insights into mechanisms that control their synthesis and enterohepatic circulation, and a growing appreciation of their roles as bioactive bacterial metabolites, bile acids are currently receiving a great deal of interest as critical regulators of epithelial function in health and disease. This review aims to summarize recent advances in this field and to highlight how bile acids are now emerging as exciting new targets for disease intervention.
Voltage-Sensing Phosphatases: Biophysics, Physiology, and Molecular Engineering
Authors: Okamura Yasushi , Kawanabe Akira , Kawai Takafumi
Published: August 2018

Voltage-sensing phosphatase (VSP) contains a voltage sensor domain (VSD) similar to that in voltage-gated ion channels, and a phosphoinositide phosphatase region similar to phosphatase and tensin homolog deleted on chromosome 10 (PTEN). The VSP gene is conserved from unicellular organisms to higher vertebrates. Membrane depolarization induces electrical driven conformational rearrangement in the VSD, which is translated into catalytic enzyme activity. Biophysical and structural characterization has revealed details of the mechanisms underlying the molecular functions of VSP. Coupling between the VSD and the enzyme is tight, such that enzyme activity is tuned in a graded fashion to the membrane voltage. Upon VSP activation, multiple species of phosphoinositides are simultaneously altered, and the profile of enzyme activity depends on the history of the membrane potential. VSPs have been the obvious candidate link between membrane potential and phosphoinositide regulation. However, patterns of voltage change regulating VSP in native cells remain largely unknown. This review addresses the current understanding of the biophysical biochemical properties of VSP and provides new insight into the proposed functions of VSP.
Copper Incorporation into CdS Thin Films by Ionic Exchange in an Aqueous Solution Process at Room Temperature
Authors: Flores-García E. , Hernández-Landaverde M. A. , González-García P. , Ramírez-Bon R.
Published: August 2018

Cadmium sulfide (CdS) thin films were deposited, on glass substrates, at 70°C for 120 min using an ammonium-free chemical bath deposition process. After deposition, the films were placed in a CuCl2 solution for 45, 60, 75, and 90 min, respectively, for their ion exchange, generating CdxCu1-xS films. The obtained films were analyzed by X-ray diffraction, Raman spectroscopy, X-ray wavelength dispersion spectrometry, and scanning electron microscopy. The reference CdS films showed a homogeneous appearance and a yellowish color; elapsing the immersion time, the films changed their color showing a greenish appearance. The X-ray analysis indicated that the CdS films developed a hexagonal structure with preferential orientation along the plane (002). During the ion exchange, a decrease in the intensity of the reflection (002) was observed as well as a slight displacement of this reflection towards higher values of 2θ derived from the substitution of Cd atoms by Cu atoms. The WDS analysis revealed that approximately 10% of the cadmium atoms were replaced by copper ones after 90 min of immersion.
Some New Coupled Coincidence Point and Coupled Fixed Point Results in Partially Ordered Metric-Like Spaces and an Application
Authors: Liang Min , Zhu Chuanxi , Wu Zhaoqi , Chen Chunfang
Published: August 2018

Some new coupled coincidence point and coupled fixed point theorems are established in partially ordered metric-like spaces, which generalize many results in corresponding literatures. An example is given to support our main results. As an application, we discuss the existence of the solutions for a class of nonlinear integral equations.
Evaluation of Iron Deficiency Anemia Frequency as a Risk Factor in Glaucoma
Authors: Firat Penpe Gul , Demirel Ersan Ersin , Dikci Seyhan , Kuku Irfan , Genc Oguzhan
Published: August 2018

Purpose. Iron deficiency anemia is an important public health problem. Also it is considered to be a risk factor for many diseases. The study demonstrates the iron deficiency anemia frequency in glaucoma patients and compares with the normal subjects. We aimed to determine the iron deficiency anemia frequency in glaucoma patients.Methods. Prospective, controlled study in a single university hospital setting. A total of 130 normal subjects (Group 1) and 131 glaucoma patients (Group 2) were included. The erythrocytes parameters, hemoglobin, red blood cell, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, and red blood cell distribution width, and iron status indicators, Fe (iron), total iron binding capacity, and ferritin of the cases, in normal subjects and glaucoma patients were compared.Results. There was no statistically significant difference for the erythrocyte parameters between the groups (p≥0.05). The number of the patients with iron deficiency anemia in both groups was similar. No statistically significant difference was found in the comparison of erythrocyte parameters and iron status indicators values according to the number of antiglaucomatous agents and visual field changes according to the presence of anemia in Group 2 (p≥0.05). A statistically significant difference was found only in MCH when the erythrocyte parameters and iron status indicators values of the cases in glaucoma patients were compared with the glaucoma duration (p<0.05).Conclusion. The iron deficiency anemia frequency was like the normal population in glaucoma patients.
Predictors of Major Depressive Disorder following Intensive Care of Chronically Critically Ill Patients
Authors: Wintermann Gloria-Beatrice , Rosendahl Jenny , Weidner Kerstin , Strauß Bernhard , Petrowski Katja
Published: August 2018

Objective. Major depressive disorder (MDD) is a common condition following treatment in the Intensive Care Unit (ICU). Long-term data on MDD in chronically critically ill (CCI) patients are scarce. Hence, the primary aim of the present study was to investigate the frequency and predictors of MDD after intensive care of CCI patients.Materials and Methods. In a prospective cohort study, patients with long-term mechanical ventilation requirements (n=131) were assessed with respect to a diagnosis of MDD, using the Structured Clinical Interview for DSM-IV, three and six months after the transfer from acute ICU to post-acute ICU. Sociodemographic, psychological, and clinical risk factors withpvalues ≤ 0.1 were identified in a univariate logistic regression analysis and entered in a multivariable logistic regression model. A mediator analysis was run using the bootstrapping method, testing the mediating effect of perceived helplessness during the ICU stay, between the recalled traumatic experience from the ICU and a post-ICU MDD.Results. 17.6% (n=23) of the patients showed a full- or subsyndromal MDD. Perceived helplessness, recalled experiences of a traumatic event from the ICU, symptoms of acute stress disorder, and the diagnosis of posttraumatic stress disorder (PTSD) after ICU could be identified as significant predictors of MDD. In a mediator analysis, perceived helplessness could be proved as a mediator.Conclusions. Every fifth CCI patient suffers from MDD up to six months after being discharged from ICU. Particularly, perceived helplessness during the ICU stay seems to mainly affect the long-term evolvement of MDD. CCI patients with symptoms of acute stress disorder/PTSD should also be screened for MDD.
Portal Hypertensive Polyposis in Advanced Liver Cirrhosis: The Unknown Entity?
Authors: Kara David , Hüsing-Kabar Anna , Schmidt Hartmut , Grünewald Inga , Chandhok Gursimran , Maschmeier Miriam , Kabar Iyad
Published: August 2018

Background. Portal hypertension is a serious complication of liver cirrhosis. Objective. To identify relevant endoscopic findings in patients with advanced cirrhosis and consecutive portal hypertension. Methods. This was a retrospective study of liver transplant candidates who underwent upper gastrointestinal endoscopy between April 2011 and November 2015. Results. A total of 1,045 upper endoscopies were analyzed. Portal hypertensive gastric and duodenal polyps were frequently observed and were associated with thrombocytopenia (p = 0.040; OR: 2.4, 95% CI 1.04–5.50), Child-Pugh score > 6 (p = 0.033; OR: 2.3, 95% CI 1.07–4.92), Model for End Stage Liver Disease score > 16 (p = 0.030; OR: 4.1, 95% CI 1.14–15.00), and previous rubber band ligation (p < 0.001; OR = 5.2, 95% CI 2.5–10.7). These polyps often recurred after polypectomy; however, no malignant transformation occurred during the observational time until October 2017. The most common endoscopic finding was esophageal varices, observed in more than 90% of patients. Conclusion. Portal hypertensive polyposis is common in patients with advanced cirrhosis. Our data suggest that these polyps have benign characteristics.
Biomarker Profiling for Pyridoxine Dependent Epilepsy in Dried Blood Spots by HILIC-ESI-MS
Authors: Mathew Elizabeth Mary , Moorkoth Sudheer , Lewis Leslie , Rao Pragna
Published: August 2018

Pyridoxine dependent epilepsy is a condition where the affected infant or child has prolonged seizures (status epilepticus), which are nonresponsive to anticonvulsant therapy but can be treated with pharmacological doses of pyridoxine. If identified earlier and treated prophylactically with pyridoxine, severe brain damage due to seizures can be prevented. Alpha-amino adipic semialdehyde (AASA), piperidine-6-carboxylic acid (P6C), and pipecolic acid (PA) are known biomarkers of pyridoxine dependent epilepsy. We report the development and validation of a hydrophilic interaction liquid chromatography (HILIC) hyphenated with mass spectroscopy for the quantification of the above analytes from dried blood spot samples. The samples were extracted using methanol and analysed on a iHILIC fusion plus column with formic acid buffer (pH 2.5): acetonitrile (20:80) at a flow rate of 0.5 mL/min within 3 minutes. The method demonstrated a LOD of 10 ng/mL, LOQ of 50 ng/mL, linearity of r2 ≥ 0.990, and recovery of 92-101.98% for all analytes. The intra- and interday precision CVs were < 8% and 6%, respectively. Extensive stability studies demonstrated that the analytes were stable in stock solution and in matrix when stored at -80°C. We performed method comparison studies of the developed method with the literature reported method using normal samples and matrix matched spiked samples at pathological concentrations to mimic clinical validity. The Bland-Altman analysis for comparison of the analytical suitability of the method for the biomarkers in healthy and spiked samples with the literature reported method revealed a bias which suggested that the method was comparable. The newly developed method involves no derivatisation and has a simple sample preparation and a low run time enabling it to be easily automated with a high sample throughput in a cost-effective manner.
Outcome after 52 Salto Ankle Prostheses Implanted by a Single Surgeon
Authors: Faber Frank W. M. , Mastboom Monique J. L. , van Vliet-Koppert Sabine T. , Bouman Ilse C. E. , van Kampen Paulien M.
Published: August 2018

While ankle arthrodesis was traditionally the gold standard method of treatment for disabling end-stage ankle arthritis, total ankle replacement (TAR) has been an acceptable alternative. The satisfaction rate of patients with TAR however differs. The purpose of our study is to investigate whether implant survival and results with special emphasis on the satisfaction rate of patients treated with a TAR implanted by a single surgeon were comparable to the literature. This was a retrospective cohort study in a teaching hospital. Data was collected from 52 patients who received a total ankle replacement (TAR) between 05/2002 and 06/2014. The mean follow-up time was 4.2 years (95% CI 3.3 – 5.0). Results showed a high satisfaction rate of 94% and 94% survival of the TAR after 5 years. We conclude that TAR with the Salto prosthesis is, in our hands, a reliable solution for end-stage ankle arthritis, with results comparable to the literature.
A Review of Selected Factors of Salivary Gland Tumour Formation and Malignant Transformation
Authors: Sowa Pawel , Goroszkiewicz Karolina , Szydelko Joanna , Chechlinska Joanna , Pluta Katarzyna , Domka Wojciech , Misiolek Maciej , Scierski Wojciech
Published: August 2018

Salivary gland tumours represent about 6% of head and neck neoplasms and about 0.5% of all malignancies in humans. Tumour growth and malignant transformation are complex processes involving various actions of molecules. Furthermore, some malignant salivary gland tumours are deemed to be caused by dedifferentiation or malignant transformation of benign tumours. The mechanisms of this transformation depend on a variety of different elements, such as cell cycle regulators, oncogenes, proteins, angiogenesis factors, and adipocytokines. The authors used PubMed, Medline, and Google websites to find and review the most significant papers related to malignant transformation in benign salivary gland tumours.
Hydrogen Sulfide Alleviates Acute Myocardial Ischemia Injury by Modulating Autophagy and Inflammation Response under Oxidative Stress
Authors: Bai Ya-dan , Yang Yu-rong , Mu Xue-pan , Lin Ge , Wang You-ping , Jin Sheng , Chen Ying , Wang Ming-jie , Zhu Yi-chun
Published: August 2018

This study aims to investigate the influence of excessive oxidative stress on cardiac injury during acute myocardial ischemia (AMI), with a focus on apoptosis, autophagy, and inflammatory cell infiltration, and to detect the role of hydrogen sulfide (H2S) in this process. We found that SOD1 knockout (KO) mice showed excessive oxidative stress and exacerbated myocardium injury after AMI. Increased apoptosis and inflammation response in the ischemic myocardium contribute to this deterioration, whereas enhanced autophagy plays a protective role. Myocardial inflammation after AMI was much more severe in SOD1 KO mice than in wild‐type mice. Pretreatment with the H2S donor NaHS reduced autophagy and apoptosis levels in the ischemic myocardium and alleviated the regional inflammation response in the cardiac tissues of SOD1 KO mice. Moreover, autophagy and apoptosis levels were significantly enhanced in SOD1 knockdown primary neonatal rat cardiomyocytes (NRCMs) under glucose deprivation. Pretreatment with NaHS can partially inhibit this elevation. Taken together, we found that excessive oxidative stress can aggravate cardiac injury during AMI. Exogenous H2S can alleviate cardiac injury during AMI by reducing apoptosis and inflammation response in heart tissues under oxidative stress.
Comparative Study of Y-Split Recession versus Faden Technique for Management of Infantile Esotropia in Egyptians
Authors: Badawi Nermeen , Ismail Ahmed Taha
Published: August 2018

Purpose. This study compares the results of Y-split recession versus de Decker’s (modified Cüppers) Faden techniques of medial rectus (MR) muscles for the management of essential infantile esotropia (IET).Patients and Methods. Fifty patients had IET divided into Group A who underwent Y-split recession of MR muscles and Group B who underwent de Decker’s Faden technique of MR muscles. All patients had complete ophthalmic examination done including deviation angle measurement and met the inclusion criteria of the study. Operations were performed using general anesthesia. Patients were followed up at day 1, week 1, and months 1, 3, and 6 after operation.Results. The mean age distribution for group A was 21.56 months (SD 12.55) and for group B was 21.4 months (SD 12.35), and the mean postoperative follow-up interval was 6 months for both groups. The preoperative maximum angle of deviation in both groups ranged from 15 to 40 degrees, while the minimum angle of deviation ranged from 10 to 20 degrees. Immediately postoperatively both groups showed 88% of patients with satisfactory results (within 10 degrees of orthotropia). Group A showed two patients (8%) with ET and one patient (4%) with exotropia (XT). For group B, it showed one patient (4%) with ET and two patients (8%) with XT. Three patients in each group underwent a second intervention. All patients remained within the satisfactory range.Conclusion. The results of this study suggest that both techniques show comparable results for the correction of IET.
A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs
Authors: Kalpana V. N. , Devi Rajeswari V.
Published: August 2018

The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Because of the high rate of poisonous chemicals and the extreme surroundings used within the chemical and physical methods, the green techniques have been adopted using plants, fungi, bacteria, and algae for the synthesis of nanoparticles. Therefore, this paper considers various green synthesis methods to provide the evidence of ZnO NP role to several applications, and in addition, biomedical applications and toxic effect were reviewed. Therefore, the paper used various secondary sources to collect the relevant review articles. From the findings, the green route of synthesis is rather safe and eco-friendly when compared to physical and chemical means of synthesis. On the other hand, its biomedical applications in this sector are increased day by day in various processes including bioimaging, drug delivery, biosensors, and gene delivery. With respect to its toxicity properties, ZnO NPs can act as smart weapons against multiple drug-resistant microorganisms and as a talented substitute for antibiotics.
Prospective Associations of the Short Form Health Survey Vitality Scale and Changes in Body Mass Index and Obesity Status
Authors: Wimmelmann Cathrine Lawaetz , Hegelund Emilie Rune , Folker Anna Paldam , Just-Østergaard Emilie , Osler Merete , Mortensen Erik Lykke , Flensborg-Madsen Trine
Published: August 2018

Objectives. The objectives of the current study were to prospectively investigate the predictive value of the vitality scale of the Short Form Health Survey for changes in body mass index and development of obesity. Methods. The study population comprised 2864 (81.5%) men and 648 (18.5%) women from the Metropolit Project and the Danish Longitudinal Study on Work, Unemployment and Health, who participated in a follow-up examination in 2009–2011 corresponding to a follow-up period of 3–7 years. Associations of vitality with body mass index and obesity were investigated separately for men and women in linear and logistic regression models adjusting for age, baseline body mass index, education, physical activity, smoking, and obesity-related diseases. Results. Vitality was significantly associated with change in body mass index among men (p<0.001) and women (p<0.05) gaining weight after adjusting for age, baseline body mass index, education, physical activity, smoking, and obesity-related diseases. No significant associations of vitality with BMI change were observed among individuals maintaining or losing weight during the follow-up period. Furthermore, vitality significantly predicted development of obesity among women. Conclusion. The study indicates that vitality is of predictive value for increases in BMI over time among individuals gaining weight and may further predict the development of obesity among women. This identification of poor vitality as a potential risk indicator for weight gain and development of obesity may be beneficial in clinical practice.
Carbon Nanoelectrodes for the Electrochemical Detection of Neurotransmitters
Authors: Zestos Alexander G.
Published: August 2018

Carbon-based electrodes have been developed for the detection of neurotransmitters over the past 30 years using voltammetry and amperometry. The traditional electrode for neurotransmitter detection is the carbon fiber microelectrode (CFME). The carbon-based electrode is suitable for in vivo neurotransmitter detection due to the fact that it is biocompatible and relatively small in surface area. The advent of nanoscale electrodes is in high demand due to smaller surface areas required to target specific brain regions that are also minimally invasive and cause relatively low tissue damage when implanted into living organisms. Carbon nanotubes (CNTs), carbon nanofibers, carbon nanospikes, and carbon nanopetals among others have all been utilized for this purpose. Novel electrode materials have also required novel insulations such as glass, epoxy, and polyimide coated fused silica capillaries for their construction and usage. Recent research developments have yielded a wide array of carbon nanoelectrodes with superior properties and performances in comparison to traditional electrode materials. These electrodes have thoroughly enhanced neurotransmitter detection allowing for the sensing of biological compounds at lower limits of detection, fast temporal resolution, and without surface fouling. This will allow for greater understanding of several neurological disease states based on the detection of neurotransmitters.
Work Ability and Employment in Rheumatoid Arthritis: A Cross-Sectional Study on the Role of Muscle Strength and Lower Extremity Function
Authors: Berner Carolin , Haider Sandra , Grabovac Igor , Lamprecht Thomas , Fenzl Karl Heinrich , Erlacher Ludwig , Quittan Michael , Dorner Thomas Ernst
Published: August 2018

Objective. The aim of the present study was to assess the association between muscle strength, lower extremity function, employment status, and work ability in RA patients.Methods.One hundred seropositive RA outpatients of working age were included in this cross-sectional study. Employment status was assessed by interview and work ability by the Work Ability Index-Single Item Scale (WAS). Muscle strength was determined using dynamometer measurement of isometric hand grip and knee extensor strength. Lower extremity function was measured using the short physical performance battery (SPPB). Regression models estimate the association between unemployment, work ability and muscle strength, and lower extremity function, controlling for sociodemographic and disease-related factors.Results. Forty-one percent of the RA patients were not gainfully employed, and their median work ability had a good WAS value (7.00[4.00-7.00]). Patients with better knee extensor strength (OR=1.07, 95% CI[1.02-1.12)and better physical performance (OR=1.71, 95% CI[1.18-2.49]) had a significantly better chance of gainful employment. The odds for hand grip strength remained significant when adjusted for sociodemographic (OR=1.5, 95% CI[1.00-1.09]), but not for disease-specific variables. Better hand grip strength (β=0.25,p=0.039) and better knee extensor strength (β=0.45,p=0.001) as well as better lower extremity function (SPPB) (β=0.51,p<0.001) remained significantly associated with work ability following adjustment for sociodemographic and disease-specific variables.Conclusions. The association of employment status and work ability with parameters of physical fitness suggests that improvement in muscle strength and lower extremity function may positively influence work ability and employment in individuals with RA.
Nonexistence of Global Weak Solutions of Nonlinear Keldysh Type Equation with One Derivative Term
Authors: Zhang Kangqun
Published: August 2018

We focus on the nonexistence of global weak solutions of nonlinear Keldysh type equation with one derivative term. In terms of the analysis of the first Fourier coefficient, we show the solution of singular initial value problem and singular initial-boundary value problem of the nonlinear equation with positive initial data blow-up in some finite time interval.
Synthesis, Characterization, and Anti-Phytopathogen Evaluation of 6-Oxychitosan Derivatives Containing N-Quaternized Moieties in Its Backbone
Authors: Gao Kun , Qin Yukun , Liu Song , Xing Ronge , Yu Huahua , Chen Xiaolin , Li Kecheng , Li Pengcheng
Published: August 2018

The structure modification of chitosan has great application potential. 6-Oxychitosan was prepared by specially oxidizing the C6-OH of chitosan, then 6-oxychitosan was reacted with three kinds of aldehydes to prepare N-quaternized 6-oxychitosan derivatives in this paper. The derivatives were characterized by FT-IR, NMR, and elemental analysis. The antimicrobial activity of these derivatives was tested against two common plant-threatening fungi and three plant disease bacteria. The results showed that N-quaternized 6-oxychitosan derivatives had good water-solubility and excellent antimicrobial activity. Moreover, derivative 3 which connected 8-hydroxyquinolines had the highest antimicrobial activity than the other derivatives. The inhibitory indices of derivative 3 against V. albo-atrum and P. hibernalis are 89.1% and 72.8% at 0.4 mg/ml. The MICs of 3 against X. oryzae, P. syringae, and E. rhapontici were 625, 625, and 156 mg/l, respectively. All the results indicate that derivative 3 has the potential of becoming an alternative to harmful agricultural chemicals.
Sofosbuvir Based Regimens in the Treatment of Chronic Hepatitis C with Compensated Liver Cirrhosis in Community Care Setting
Authors: Gayam Vijay , Mandal Amrendra Kumar , Khalid Mazin , Mukhtar Osama , Gill Arshpal , Garlapati Pavani , Khalid Mowyad , Mansour Mohammed
Published: August 2018

Background. Direct-acting antiviral (DAA) drugs have been highly effective in the treatment of chronic hepatitis C (CHC) infection. We aim to evaluate the treatment response of Sofosbuvir based DAA in CHC patients with compensated liver cirrhosis as limited data exists in the real-world community setting. Methods. All the CHC patients with compensated liver cirrhosis treated with Sofosbuvir based DAAs between January 2014 and December 2017 in a community clinic setting were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy with the sustained virologic response at 12 weeks posttreatment (SVR12), and adverse reactions were assessed. Results. One hundred and twelve patients with CHC infection and concurrent compensated cirrhosis were included in the study. Black patients represented the majority of the study population (64%). Eighty-seven patients were treated with Ledipasvir/Sofosbuvir (LDV/SOF) ±Ribavirin and 25 patients were treated with Sofosbuvir/Velpatasvir (SOF/VEL). Overall, SVR 12 after treatment was achieved in 90% in patients who received one of the two DAA regimens (89.7% in LDV/SOF group and 92% in SOF/VEL group). SVR 12 did not vary based on age, sex, body mass index, baseline HCV viral load, HCV/HIV coinfection, type of genotype, and prior treatment status. Apart from a low platelet count, there were no other factors associated with a statistical difference in SVR 12(p=0.002) between the two regimens. Fatigue (35%) was the most common adverse effect and no patients discontinued treatment due to adverse effects. Conclusion. In the community care setting, Sofosbuvir based DAAs are safe, effective with high overall SVR, and well tolerated in patients with CHC patients with compensated liver cirrhosis.
Association between Obesity and Carotid Intima-Media Thickness in Korean Office Workers: The Mediating Effect of Physical Activity
Authors: Jin Youngyun , Kim Donghyun , Cho Jinkyung , Lee Inhwan , Choi Kyuhwan , Kang Hyunsik
Published: August 2018

Background. Obesity and physical inactivity are associated with higher prevalence of cardiovascular disease (CVD). Objective. This study investigated the association between obesity and carotid intima-media thickness (CIMT) stratified by physical activity (PA) in Korean office workers. Methods. Data obtained from 914 office workers aged 21-60 years (347 women) were used. Resting blood pressures, body mass index (BMI), and waist-to-height ratio (WHtR) were measured. PA was assessed using the international physical activity questionnaire. CIMT was assessed with a carotid artery ultrasonography. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence interval (CI) of obesity stratified by weekly PA for an abnormally increased CIMT. Results. Logistic regression analyses showed that those who were overall obese (OR=2.50, 95% CI=1.60-3.91, P<0.001) or central obese (OR=2.08, 95% CI=1.29-3.40, P=0.003) had significantly higher estimated risks of having an abnormally increased CIMT even after adjustments for age, sex, smoking, alcohol consumption, resting blood pressures, and history of hypertension, diabetes, and hyperlipidemia, as compared with those who were not overall or central obese (OR=1). A multivariate linear regression suggested that age (P<0.001), sex (P=0.002), hypertension (P=0.014), smoking (P=0.054), BMI (P<0.001), and physical activity (P=0.011) were important determinants of abnormally elevated CIMT in this study population. Conclusion. The current findings suggest that the risk of obesity for an abnormally increased CIMT is significantly modulated by demographics as well as lifestyle-related risk factors including smoking and physical inactivity in Korean office workers.
Exhaust Emissions and Physicochemical Properties of Hydrotreated Used Cooking Oils in Blends with Diesel Fuel
Authors: Zahos-Siagos Iraklis , Karonis Dimitrios
Published: August 2018

Hydroprocessing of liquid biomass is a promising technology for the production of “second generation” renewable fuels to be used in transportation. Its products, normal paraffins, can be further hydrotreated for isomerization in order to improve their cold flow properties. The final product, usually referred to as “paraffinic diesel,” is a high cetane number, clean burning biofuel which is rapidly gaining popularity among researchers and the industry. Nevertheless, the costly isomerization step can be omitted if normal paraffins are to be directly mixed with conventional diesel in low concentrations. In this work, nonisomerized paraffinic diesel produced through hydrotreating of used cooking oil (hydrotreated used cooking oil (HUCO)) has been used in 4 blends (up to 40% v/v) with conventional diesel fuel. The blends’ properties have been assessed comparatively to European EN 590 and EN 15940 standards (concerning conventional automotive diesel fuels and paraffinic diesel fuels from synthesis or hydrotreatment, resp.). Furthermore, the HUCO blends have been used in a standard stationary diesel engine-generator set. The blends have been considered as “drop-in replacements” for standard diesel fuel. As such, no engine modifications took place whatsoever. The engine performance and exhaust emissions of steady-state operation have been examined in comparison with engine operation with the baseline conventional diesel fuel.
Natural Cytotoxicity Receptors in Decidua Natural Killer Cells of Term Normal Pregnancy
Authors: Takahashi Hideki , Yamamoto Tatsuo , Yamazaki Motomi , Murase Takayuki , Matsuno Takayuki , Chishima Fumihisa
Published: August 2018

Aim. To investigate the changes in the maternal immune system at term pregnancy, we studied the expression of natural cytotoxicity receptors (NCRs) and the cytokine production of NK cells in term placenta decidua and peripheral blood. Methods. Term decidua and peripheral blood were taken from patients undergoing elective cesarean section. The lymphocytes were separated using density gradient centrifugation (DGC) from peripheral blood and were separated from decidua using DGC after enzyme digestion. These cells were stained with FITC anti-CD56 and Per-CP anti-CD3 monoclonal antibodies, and the NCRs were stained with PE-conjugated anti-NKG2D, NKp46, NKp30, and NKp44 monoclonal antibodies. Cytokines, including IFN-γ, TNF-α, IL-10, and TGF-β, were stained and then analyzed by flow cytometry. Results. There were fewer cells positive for NKG2D, NKp46, and NKp30 among CD56+CD3- cells in deciduas than in peripheral blood, but the percentages of NKp44-positive cells in CD56+CD3- lymphocytes in deciduas tended to be higher. Conclusion. The decreased expression of some NCRs in deciduas may be related to decreased cytotoxicity at term pregnancy, but the increased expression of NKp44 may affect the increased cytokine production in the decidua. Similarly, the expression of NCRs in the decidua may be connected to the maintenance of pregnancy at term.
Utilization of Long-Lasting Insecticide Treated Nets and Parasitaemia at 6 Months after a Mass Distribution Exercise among Households in Mbarara Municipality, Uganda: A Cross-Sectional Community Based Study
Authors: Nuwamanya Simpson , Kansiime Noel , Aheebwe Emmanuel , Akatukwasa Cecilia , Nabulo Harriet , Turyakira Eleanor , Bajunirwe Francis
Published: August 2018

Background. Utilization of long-lasting insecticide treated nets (LLINs) after free and mass distribution exercise has not been adequately studied. The objectives of this study were to assess ownership and utilization of LLINs following a mass distribution campaign in a Ugandan urban municipality. Methods. We conducted a cross-sectional study in western Uganda among households with children under 5 years, at 6 months after a mass LLIN distribution exercise. We administered a questionnaire to measure LLIN ownership and utilization. We also measured parasitaemia among children under five years. Results. Of the 346 households enrolled, 342 (98.8%) still owned all the LLINs. LLIN use was reported among 315 (91.1%) adult respondents and among 318 (91.9%) children under five. Parasitaemia was detected among 10 (2.9%) children under five. Males (OR=2.65, 95% CI 0.99-7.07), single respondents (OR=10.35, 95% CI 1.64-65.46), having a fitting bed net size (OR= 3.59, 95% CI 1.71-7.59), and no childhood malaria episode reported in the home in the last 12 months (OR=1.69, 95% CI 1.02-2.83) were all associated with LLIN use. Conclusions. Ownership of LLIN is very high, and parasitaemia among the children was very low. Low parasitaemia may be attributed to high LLIN utilization. Long term follow-up should be done to determine durability of the ownership and utilization.
Bioaugmentation with Mixed Hydrogen-Producing Acetogen Cultures Enhances Methane Production in Molasses Wastewater Treatment
Authors: Wang Shuo , Li Jianzheng , Zheng Guochen , Du Guocheng , Li Ji
Published: August 2018

Hydrogen-producing acetogens (HPA) have a transitional role in anaerobic wastewater treatment. Thus, bioaugmentation with HPA cultures can enhance the chemical oxygen demand (COD) removal efficiency and CH4yield of anaerobic wastewater treatment. Cultures with high degradation capacities for propionic acid and butyric acid were obtained through continuous subculture in enrichment medium and were designated as Z08 and Z12. Bioaugmentation with Z08 and Z12 increased CH4production by glucose removal to 1.58. Bioaugmentation with Z08 and Z12 increased the COD removal rate in molasses wastewater from 71.60% to 85.84%. The specific H2and CH4yields from COD removal increased by factors of 1.54 and 1.63, respectively. Results show that bioaugmentation with HPA-dominated cultures can improve CH4production from COD removal. Furthermore, hydrogen-producing acetogenesis was identified as the rate-limiting step in anaerobic wastewater treatment.