bluuebunny/crossref_metadata_2025 huggingface dataset:
A case report of perforated appendicitis with pyoperitoneum in a tertiary care center
Authors: M. Yashfeen , R. Manivannan
Published: July 2023

Acute appendicitis remains one of the most frequent reasons for emergency hospital admissions and the most common cause of an 'acute abdomen' in young adults. The risk of appendicitis is 8.6% for men and 6.7% for women throughout a lifetime, with the frequency peaking in the second decade of life. In 19% of acute appendicitis cases, there is perforation, and it has a bimodal distribution. Appendiceal gangrene and perforation appear to be caused by the appendiceal lumen being blocked. Gangrenous appendicitis and free bacterial contamination of the peritoneal cavity result from ischaemic necrosis of the appendix wall. Extreme ages, diabetes mellitus, immunosuppressive diseases, and obstruction of the appendix lumen are risk factors for appendix perforation. Advances in radiographic imaging have increased diagnostic accuracy, although the diagnosis of acute appendicitis remains primarily clinical. Ultrasound, computed tomography (CT) scans, and magnetic resonance imaging (MRI) scans are the imaging modalities presently in use. Early appendectomy continues to be the best option and the least contentious treatment for acute appendicitis. The accepted standard of care for perforated appendicitis includes both open and laparoscopic procedures. Antibiotic prophylaxis responds effectively to complicated appendicitis.
A case of successfully resected Shamblin type III carotid body tumour without vascular reconstruction
Authors: Sreekumar Surabhi , Raghunath K. J. , Vijayalakshmi S. , . Sneha
Published: July 2023

Carotid body tumours (CBT) are rare vascular neoplasms arising from the bifurcation of the common carotid artery, and are benign tumors with low incidence, slow growth, and low rate for malignant transformation. A rare functional CBT may produce neuroendocrine secretions causing catecholamine-related symptoms, such as palpitations, headaches, hypertension, tachycardia, or flushing. These tumours have classic radiographic features. These lesions splay apart the internal (ICA) and external carotid arteries (ECA), and as it enlarges, it will encase, but not narrow the ICA and ECA-Lyre’s sign. If a diagnosis of CBT is suspected following a detailed physical examination, the diagnosis is almost always established by radiological imaging methods such as duplex ultrasonography, computed tomography (CT) angiography, magnetic resonance (MR) angiography, and digital subtraction angiography. These tumours were classified by Shamblin, according to the gross tumor vessel relationship and was based on the radiology, intraoperative findings and postoperative specimen examination. Group 1 tumors were minimally attached to the vessels and easily resectable. Group 2 tumors seemed to partially surround the vessel and were more adherent to vessel adventitia. These tumors were difficult to dissect but amenable to careful resection. Shamblin group 3 tumors had an intimate adherent relationship to the entire circumference of the carotid bifurcation and are usually inoperable. Surgical excision still remains the gold standard therapeutic modality for the treatment of CBTs. Radiotherapy is an alternative treatment modality which may decrease the tumor size or stop its growth. It is recommended for patients who cannot undergo surgery on account of extensive involvement, multiple tumors, and high operative and anesthetic risk.
E-cadherin expression – Significance in gastric carcinoma
Authors: J Divya , R Prathipaa
Published: July 2023

Gastric carcinoma is aggressive cancer with poor prognosis. E-cadherin is 120 kD calcium mediated transmembrane glycoprotein that forms the cell adhesion molecule which maintains the integrity of epithelial cells by keeping it cohesive. E-cadherin down regulation in gastric cancer is of great significance in the dissociation of epithelial cells, alteration of tumor microenvironment, invasion, tumor genesis and metastasis. 

To study the E-cadherin expression in gastric carcinoma and to correlate with the existing clinical and pathological parameters.

The study included 100 confirmed cases of adenocarcinoma from gastrectomy specimens. Immunostaining was done with E-cadherin mouse monoclonal antibody and expression studied based on the staining pattern and correlated with various clinico-pathological parameters. Data was statistically analysed by chi square test with calculation of p-value.

E-cadherin expression showed aberrant staining in 87% cases.  E-cadherin expression showed significant correlation with histological types, tumor grade, tumor depth of invasion, lymphovascular invasion and lymphnode involvement. The expression E-cadherin in gastric cancer was aberrant in 100 % of diffuse type and poorly differentiated tumors. 96.61% of lymph node positive cases showed aberrant expression. The cases with aberrant expression were comparatively more in T3 (100%) and T4 (93.75%) tumors.

The study highlights the significance of E-cadherin expression in gastric carcinoma that can be utilised as a potent bio marker for aggressiveness, metastasis and prognosis.
Factors affecting the severity of COVID-19 and the development of complications
Authors: Radygina Lubov V. , Mochalova Larisa V.
Published: July 2023

Due to the prevalence and diversity of both symptoms and outcomes of COVID-19, understanding the factors that determine the risk of the severe course of this disease and its possible complications is of particular importance. In this review, we present the information on the specifics of COVID-19 pathogenesis and give a theoretical justification for the factors that determine the course of this disease in patients of different age groups, patients with chronic pathology, and pregnant women. Particular attention is paid to the post-COVID syndrome.
Visual Inferential Elements in EFL Learning in Mbujimayi
Authors: DIKELELA KAPINGA Désiré , CIBANGU MBAYA Patrice , KABUYI KAHAMBA Patrick
Published: July 2023

The paper focuses on some inferential elements in EFL learning in Mbujimayi. More specifically, the study points out differences occurring in English sound production of /t/, /dʒ/, /ʒ/, /ð/, /v/, and /θ/ by Ciluba speaking learners. After discussing the findings obtained from observation and questionnaire, it has been discovered that the learners’ prior linguistic knowledge justifies the errors they make in this regard, the linguistic patterns of the target language being unfamiliar to them.  To remedy the issue, we suggest three things: (1) attention, implying that the teacher should work to make the learners recognize words so that they can be aware of them as useful language items. (2)  Retrieval, standing for the process indicating that a word may be noticed by the learners and understood in the textual input to the task. (3) Generation, which implies requiring of the learners to use the wanted item in new contexts.
Relações entre a ocupação de escolas, a reforma do ensino médio e a BNCC
Authors: Flach Simone de Fátima , Schlesener Anita Helena
Published: July 2023

Sob a luz dos ensinamentos gramscianos e a partir de pesquisa bibliográfica e documental, o presente texto discute sobre a relação entre as ocupações secundaristas ocorridas no ano de 2016, a Reforma do Ensino Médio e a Base Nacional Comum Curricular (BNCC). Para tanto procura desvelar os interesses presentes em documentos legais e normativos para o Ensino Médio, de forma a demonstrar como tais documentos interferem na oferta educacional e na formação de jovens brasileiros. Nessa perspectiva, o presente texto tece considerações acerca da relação entre os argumentos que fundamentaram as Ocupações Secundaristas, a aprovação da Reforma do Ensino Médio e a Construção da BNCC para essa etapa da Educação Básica, e, apresenta os interesses que estiveram em disputa na elaboração de documentos legais e normativos e os limites deles decorrentes para a formação dos jovens brasileiros. As análises indicam que a oferta do Ensino Médio no Brasil está vinculada aos interesses capitalistas, os quais interferem na formação dos jovens para torná-los subservientes à lógica do mercado e impedem uma formação emancipatória integral.
UNIVERSITIES – A NEW WAY FOR DEVELOPMENT
Authors: TERZIEV Venelın
Published: July 2023

This research analyses the role of universities as a driving force of development, as part of a developing high-tech society that sets different standards and focus areas. The reversed top-down direction with the set requirements and criteria for growth gave university education and science a high formalism, which is expressed in self-sufficient academic growth, not particularly effective project funding and untapped potential for society.

European and national policies in the field of education and science are being analyzed, which are expected to generate ideas and new models for development, form new focus areas and positions that will not reflect everyday life in the system, but will look years ahead. Reforming universities has long been on the agenda mainly, but not only, due to changes in the social environment, in the economy, in technologies, in risks and pandemics. Universities are the ones that “produce” human resources for the leadership of the state, for the management and maintenance of each system.

This work attempts to discuss knowledge sharing as part of the Open Science movement. It attempts to briefly analyse its historical development and the options for modern implementation of the open science idea. It discusses the process of knowledge sharing as an element of recognition of scientific works and part of social development. It seeks a solution to the established national and other restrictions for sharing of knowledge, as well as its importance in the situation of limited sharing. The article also discusses the process of changes in the higher education system in Bulgaria related to the consolidation of Bulgarian universities
Study on Salinity Reduction and Changes in Chemical Properties in Saline Soil
Authors: Purbajanti Endang Dwi , Kusmiyati Florentina
Published: July 2023

Background: The aim of the work was to evaluate the effects of different treatments viz manure as organic amendments, gypsum as amendments and nitrogen resources on salinity of saline soil. Methods: The research was conducted using a 2×4×3 factorial design. The first factor was manure (non-manure and manure), the second factor was the addition of gypsum, @ 0, 0.75, 1.5 and 3.0 ton ha-1) and third factor was source of nitrogen i.e. without N, nitrate and ammonium fertilizer. These three factors were repeated 3 times. Data were analyzed using one-way analysis of variance followed by the Duncan multiple range test for comparisons among means with a significance level of 5%. Result: This research markedly reduced pH, EC, Na and markedly increased sulfate, K content. But CEC, SAR, ESP, total N, nitrate, ammonium were not significant. The highest Ca content was in the 1.5 tons ha-1 gypsum treatment and non manure. Meanwhile, in the interaction between gypsum and N resources, the highest Mg content was 3 tons ha-1 of gypsum and nitrate.
Balanced Fertilization for Sustainable Yield and Quality of Peanut (Arachis hypogaea L.) in Sandy Soil of Central Vietnam
Authors: Trinh T.S. , Hoang T.T.H. , Do D.T. , Tran T.D. , Tran T.A.T. , Vu T.M. , Intizar-ul-Hassan M. , Rehman H.
Published: July 2023

Background: Peanut (Arachis hypogaea L.) plays an important role in cropping systems with sandy soil. However, studies on peanut cultivation in sandy soil of Binh Dinh province, Central Vietnam are still limited due to imbalanced fertilizer use. Methods: The present study compared two different fertilizer combinations including (T1) Control (Farmers’ practice): 24 kg N (urea) + 74 kg P2O5 (Thermophosphate) + 84 kg K2O (KCl) + 100 kg NPK (16 - 16 - 8 - 13S) ha-1 and (T2) 40 kg N (urea) + 90 kg P2O5 (Thermophosphate) + 90 kg K2O (K2SO4) based on 8 tons of cattle manure + 500 kg lime ha-1 on peanut yield, quality and some physico-chemical properties of the sandy soil. All treatments were arranged in a completely randomized block design (RCBD) with 3 replicates in Cat Hanh and Cat Hiep communes, Phu Cat district, Binh Dinh province. Results: The results showed that the application of fertilizer combination including potassium and sulfur increased peanut yield (4.35 - 4.48 tons/ha), protein content (24.4%), lipid (52.5 - 52.8%), and improved some soil physico-chemical properties (N 9.09% and P2O5 11.04%). Thus, balanced fertilizer application including 8 tons of cattle manure + 40 kg N + 90 kg P2O5 + 90 kg K2O (K2SO4) + 500 kg of lime ha-1 can be recommended for the best peanut production in sandy soil of Central Vietnam.
Tumor microenvironment highlighting tumor-associated macrophages and immune cells
Authors: Lodetti Zangrandi Giulio , Tirpanlar Dilruba , Pastore Mirella , Soldani Cristiana , Lleo Ana , Raggi Chiara
Published: July 2023

Cholangiocarcinoma (CCA) grows within a highly desmoplastic microenvironment, exhibiting a continuous interconnection with the immune infiltrate, which is characterized by an abundance of immune cells, including natural killer cells, T lymphocytes, and macrophages. The presence of inflammatory cells within the tumor microenvironment plays a crucial role in determining the aggressiveness and growth of CCA. The immune cell population engages in diverse and dynamic interactions with cancer cells. The balance of different subpopulations within CCA can generate varying responses, either inhibiting or promoting tumoral progression. The purpose of this review is to offer a comprehensive overview of the role of various immune infiltrate subpopulations within the tumor microenvironment, with a particular focus on the actions of tumor-associated macrophages (TAMs) and their critical regulation in the development and progression of CCA. TAMs play vital roles in maintaining homeostasis, facilitating tissue repair, and contributing to immune responses due to their significant functional diversity. Macrophages are present in numerous types of cancer, and their emerging role has also been observed in CCA. Recognizing and attaining a deeper comprehension of the intricate interplay between infiltrating immune cells and CCA cells is essential to identify new opportunities to advance treatment strategies.
Anthropogenic activities and COVID-19 effects on natural water bodies: Arroyo Seco’s case
Authors: Coronado-Apodaca Karina G. , Aguayo-Acosta Alberto , Armenta-Castro Arnoldo , Rodríguez-Aguillón Kassandra O. , Ovalle-Carcaño Antonio , Meléndez-Sánchez Edgar Ricardo , Valenzuela-Amaro Hiram Martín , Sosa-Hernández Juan Eduardo , Oyervides-Muñoz Mariel Araceli , Parra-Saldívar Roberto
Published: July 2023

Concerns about pollution in Arroyo Seco, an important natural water body in the Monterrey Metropolitan Area, have been reported due to possible wastewater discharges and solid waste mismanagement, turning the river into a potential public health hazard in the context of the COVID-19 pandemic. As a result, a volunteer clean-up campaign denominated “Arroyo Vivo” has been promoted by Distrito Tec and the Campana-Altamira initiative. To aid in the efforts, ammonium, nitrates, nitrites, and sulfate concentrations, total solids, and total organic matter were measured in parallel with SARS-CoV-2 detection and quantification in river water samples. Compared with applicable regulations (NOM-001-SEMARNAT-2021, NOM-127-SSA1-2021), total suspended solid levels (55-365 mg/L) were found above the maximum limit (84 mg/L), while ammonium (0.0175-0.198 mg/L), nitrite (0.0585-0.169 mg/L), nitrate (1.065-3.285 mg/L), sulfate (91.2-111 mg/L), and chemical oxygen demand (16.95-43.1 mg/L) were consistently below the maximum limits (0.50, 0.90, 11.00, 84.00, 400.00, and 100.00 mg/L, respectively), showing that no large-scale wastewater discharges had taken place in Arroyo Seco. However, SARS-CoV-2 genetic material was detected at three sampling sites, indicating some degree of sewage leakage and inadequate management of solid waste containing respiratory fluids of infected patients. While reports indicate that water bodies are not sources of SARS-CoV-2 infection in surrounding populations, it proves that waste disposal policies must be enforced more strictly to ensure water quality and environmental protection towards sustainable development. Nonetheless, continued efforts to screen concerning contaminants are still needed to fully assess the environmental status of the stream and propose relevant public policy.
IMPLEMENTASI PROGRAM FOOD ESTATE DI DESA BAHAUR TENGAH, KECAMATAN KAHAYAN KUALA, KABUPATEN PULANG PISAU
Authors: Mahardhika Ode , Azkar Nurul , Ariyani Erma
Published: July 2023

Food Estate adalah program nasional milik Presiden Joko Widodo yang dicanangkan salah satunya di Kalimantan Tengah tepatnya di Kabupaten Kapuas, Pulang Pisau, dan Gunung Mas. Program ini mirip dengan program PLG pada jaman Presiden Soeharto tetapi mengalami kegagalan akibat kurangnya perhatian terhadap aspek teknis, lingkungan, sosial, ekonomi, dan budaya setempat. Lalu, apakah program Food Estate ini belajar dari kegagalan program PLG karena berbenturan dengan sistem sosio-kultural masyarakat setempat? Pertanyaan mendasar inilah yang menjadi inspirasi penelitian tentang Implementasi Kebijakan Program Food Estate dengan lokus di Desa Bahaur Tengah Kecamatan Kahayan Kuala Kabupaten Pulang Pisau. Penelitian ini menggunakan pandangan kunstruktivisme karena mengandalkan sebanyak mungkin pandangan partisipan tentang situasi yang sedang terjadi. Instrumen utamanya adalah peneliti sendiri yang turun ke lapangan berinteraksi dengan masyarakat setempat.Hasil penelitian menunjukkan bahwa program Food Estate ternyata mengulangi kesalahan program PLG Orde Baru. Aspek-aspek sosial, budaya, teknis, ekonomi, dan kelembagaan ekonomi setempat terabaikan. Hal tersebut disebabkan program Food Estate bersifat sentralistik, tidak memberi ruang bagi masyarakat, khususnya para petani yang lebih memahami kondisi lokal untuk memberikan saran dan masukan guna perbaikan program. Untuk itu disarankan agar pemerintah melakukan perubahan kebijakan, khususnya dalam implementasi kebijakan untuk lebih adaptif dengan kondisi lokal.
Rumput (Cyperaceae) di Habitat Rawa Bervegetasi Galam di Kecamatan Bati-Bati, Kalimantan Selatan
Authors: Sarah Siti , Dharmono Dharmono , Riefani Maulana Khalid
Published: July 2023

Cyperaceae has a very large number of members and massive distribution. Species of Cyperaceae live around water and land. The grass (family Cyperaceae) that lives around galam-vegetated swamps in Bati-Batii sub-district has never been studied. Cyperaceae plants can be used as environmental bioindicators. This study to describe the plant species Cyperaceae in the Galam (Melaleuca cajuputi subsp. cumingiana) vegetated swamp. The research method uses a descriptive approach. The research area is a swamp with galam vegetation in Bati-Bati District. There were 5 species of Cyperaceae (Cyperus pilosus, Cyperus pulcherrimus, Eleocharis dulcis, Fimbristylis autumnalis, and Fuirena umbellata). Environmental factors affect the presence of species from Cyperaceae in the Galam vegetated Swamp area.
Keanekaragaman Jenis Rumput (Genus Cyperus) di Kawasan Persawahan Pasang Surut Desa Beringin Kencana Kecamatan Tabunganen
Authors: Dari Cici Ayu Wulan , Hardiansyah Hardiansyah , Noorhidayati Noorhidayati
Published: July 2023

Cyperus is herbaceous plant from the Cyperaceae. This plant has a triangular stem with compound flowers. Cyperus grows a lot around rice fields because this habitat supports its life. The species diversity of Cyperus has not been recorded around the rice fields of Beringin Kencana village. The purpose of this study was to describe the species diversity of the Cyperus genus in the rice fields of Beringin Kencana Village, Tabunganen District. Descriptive method with roaming technique on line transect is used in this research. The results showed that Cyperus polystachyos, Cyperus odoratus, Cyperus rotundus and Cyperus sphacelatus lived around the rice fields of Beringin Kencana Village, Tabunganen District. The species diversity index of Cyperus is in the moderate category (H' = 1.37).
Pengaruh Komposisi Media Tanam dan Dosis Pupuk Nitrogen Terhadap Pertumbuhan Tanaman Bit Merah (Beta vulgaris L.)
Authors: Nuryanti Anissa Diah , Wurjani Widi , Djarwatiningsih P.S Rr
Published: July 2023

Red beet (Beta vulgaris L.) is a plant with low productivity, so it is necessary to increase productivity by optimally cultivating plants. This study aims to examine the composition of the planting medium and the right dose of nitrogen fertilizer to increase the growth and yield of red beet plants which was carried out from March to June 2022 in Sengkrakan Hamlet, Bedali, Lawang District, Malang Regency, East Java. This study was designed using a factorial randomized block design (RAKF) with the first factor being the composition of the growing media consisting of three levels, namely, soil, soil and compost, soil and cow manure. The second factor is the dose of nitrogen fertilizer which consists of four levels, namely, 50 kg N/ha, 75 kg N/ha, 100 kg N/ha and 125 kg N/ha. The analysis used in this study is analysis of variance followed by the BNJ test at 5% level with the help of computer programs MS. Excel and SPSS. Combination treatment of soil planting media composition and cow manure with a dose of nitrogen fertilizer 50 kg N/ha can increase the height of red beet plants aged 35, 42, 63 and 70 days after planting, increase the number of leaves of red beet plants aged 14 and 28 days after planting and increase dry weight. red beet plant.
Validitas Buku Ilmiah Populer Etnobotani Artocarpus altilis (Sukun) di Desa Sabuhur Kecamatan Jorong
Authors: Rahmawati Rina , Dharmono Dharmono , Mahrudin Mahrudin
Published: July 2023

Popular Scientific Book is one of learning resources that can be developed in teaching Ethnobotany. Ethnobotany is related to the use of plants by the local community. Information on ethnobotanical studies in the form of teaching materials is still limited. The use of regional potential-based teaching materials can be a source of learning and preservation of living things. It is necessary to develop teaching materials based on local potential. Prior to use, the BIP needs to be validated to identify deficiencies. This study aims to describe the validity of the popular scientific book Ethnobotani Artocarpus altilis in Sabuhur Village, Jorong District. BIP products were evaluated by Tessmer's formative test. Formative evaluation is limited to self-evaluation and expert testing. The results of the validation of the BIP show that the category is very valid on the contextual aspect, content completeness, appearance, and language, as well as according to the rules for its preparation.
Botanical Printing dari Tumbuhan Pteridophyta Tahura KGPAA Mangkunagoro I
Authors: Sari Dewi Puspita , Siwie Yessy Ratna , Primahesa Alfian , Harlita Harlita
Published: July 2023

Botanical printing is a method of printing motifs from plant parts such as leaves, flowers, and bark onto natural fiber media, animal skin, ceramics, and wood. Botanical printing products generally use mordants (metals and minerals) and natural dyes from species of seed plants. Research on pteridophytes in Tahura KGPAA Mangkunagoro I has been conducted in 2019, but is still limited to identification and has not been utilized for art crafts. The purpose of this study is to create textile products with pteridophyte leaf motifs from the Tahura KGPAA Mangkunagoro I area. The type of research conducted is qualitative descriptive research. Sampling was done using purposive sampling techniques. The creation of botanical printing art crafts uses textile materials from plants such as rayon and canvas. The textile raw materials are processed using steaming techniques. The research results show that 20 species of pteridophytes from 9 different families (Polypodiaceae, Thelypteridaceae, Lycopodiaceae, Nephrolepidaceae, Dryopteridaceae, Pteridaceae, Hymenophyllaceae, Asplenidaceae, Athyriaceae) can be used as a source of natural motifs in the creation of botanical printing art crafts.
Kepraktisan Buku Ilmiah Populer Botani Tumbuhan Rawa Dalam Melatihkan Keterampilan Berpikir Kritis Mahasiswa
Authors: Dharmono Dharmono , Utami Nurul Hidayati , Sari Mella Mutika
Published: July 2023

Researches on the development of teaching materials in universities in the learning process to Improving higher-order thinking in plant Botany courses based on local materials are currently very necessary. Various forms of teaching materials were developed to Improving critical thinking skills. One of them is a popular scientific book.  This study aims to test the practicality of the popular scientific book (BIP) Botany of Swamp Plants in improving students' critical thinking skills in studying Higher Plant Botany. The type of research was Research and Development (R&D). The research subjects were 13 students of the Biology Education Study Program at Lambung Mangkurat University, with the object of research being BIP Botany of Swamp Plants. Practicality data was obtained based on the readability tests of three students, and 10 students. The research data were analyzed descriptively. The results showed that the BIP Botany of Swamp Plants which was developed practically (very practical category) was used to improve students' critical thinking skills.
Pengaruh Pemberian Mulsa dan Pengaturan Jarak Tanam Terhadap Pertumbuhan Jagung Manis (Zea mays saccharata Sturt.)
Authors: Lestari Deva Pratiwi Ayu , Pribadi Didik Utomo , Sutini Sutini
Published: July 2023

Corn is a horticultural commodity that people love because it contains a lot of high-quality nutrition and is beneficial for human health. One of the examples is sweet corn. Sweet corn is usually planted in a plateu, and it needs some environmental manipulation to be planted in a low plain. The purpose of this research is to find out about the role of mulch and plant space setting, with the hope that organic mulch and plant space setting will produce good results for plants and that sweet corn will grow in the low plain productively both in quantity and quality. The research is held in a moorland at Pabian, Sumenep, Madura with an altitude of ±500 meters above sea level. This research is a factorial experiment that is arranged based on a split plot design (SPD) that consists of two factors. Factor 1 is the use of mulch as a subplot that consists of no mulch (control), rice straw mulch, and plastic mulch. Factor 2 is plant space on the main plot. The interaction between the two treatments above has a significant effect on the leaf’s chlorophyll and the number of cob seeds. The average treatment plant spacing is 70 x 40, and the plastic mulch gives good growth and results.
Studi Filogenetik Kantung Semar (Nepenthes spp.) Berdasarkan Sekuens Gen Nep2 dan trnK di Paparan Sunda: Studi in Silico
Authors: Indahsari Lilin Ika Nur
Published: July 2023

The pitcher plant (Nepenthes spp.) has the highest species diversity in Sunda Shelf. This study aims to analyze the phylogenetic profile of Nepenthes spp. in Sunda Shelf based on Nep2 and trnK gene sequences. This research was conducted by in silico, downloaded from the Genbank website. The sequences consisted of 21 species for the Nep2 gene sequence and 29 species for the trnK gene sequence. The Nepenthes species used in this study were Nepenthes of Sunda Shelf including Sumatera and Kalimantan as in group also Nepenthes of Sulawesi and Papua as out group. The downloaded sequences were then analyzed for their genetic distance using p-distance method. The phylogenetic tree was constructed using Maximum Likelihood analysis on MEGAX software. The results of the phylogenetic tree analysis based on Nep2 gene sequences showed that there were 2 main clades, clade I which consisted of 19 Nepenthes species of Kalimantan, Sumatera, and Sulawesi and clade II which consisted of two species, namely N. Tobaica (Sumatera) and N. Papuana (Papua). The phylogenetic tree analysis based on the trnK gene showed that there were 2 main clades, clade I consisting of 26 Nepenthes species of Kalimantan, Sumatera, Sulawesi, and Papua and clade II consisting of N. hamata (Sulawesi), N. muluensis and N. murudensis (Kalimantan). A Total of 26 species in clade I have a genetic distance between 0.05%-2.17%, while the 3 species in clade II have a genetic distance between 8.27%-10.02%. Differences in genetic distance and the formation of clades in the phylogenetic tree are predicted to be due to the geological history of the formation of islands originating from the Sunda Shelf and Sahul Shelf.
Pengaruh Pemberian Ekstrak Daun Ara Sungsang (Asystasia gangetica) Terhadap Jumlah Sel Fibroblas pada Mencit (Mus musculus) yang Mengalami Luka Sayat
Authors: Maretta Gres , Okvitania Diah , Nurhayu Winati
Published: July 2023

Chinese violet is a type of herbaceous plant that is widely used in medication. Chinese violet has anti-inflammatory, analgesic and antimicrobial properties. This plant can be used in incision wounds. This study aims to analyze the effect of chinese violet leaf extract on the number of fibroblast cells of mice that experienced incision wounds. Experimental research was conducted using a completely randomized design method on 25 male mice weighing 20-50 grams. The research group was divided into five, namely K1 as a negative control (aquades), K2 as a positive control (povidone iodine), K3 as much as 5% of breech fig leaf extract, K4 as much as 10% of breech fig leaf extract, and K5 as much as 15% of fig leaf extract breech. The incision was made using a scalpel with a length of 2 cm and a depth of ± 2 mm. Data were analyzed using ANOVA with α = 0.05 and the LSD follow-up test. The results showed that the highest average increase in the number of fibroblast cells was found in treatment K4 (40.88) close to K2 (41.36), followed by K5 (40.04), K3 (38.64) and K1 (22.64) . The results of this study can be concluded that the breech chinese violet fig extract has a significant effect on the number of fibroblast cells.
Case Study: Roof Truss Structure With Large Cut Out and Elliptic Glazing Surface
Authors: Nagy Zsolt , Kiss Zoltán , Kelemen Andrea , Bálint Károly , Sánduly Annabella
Published: July 2023

The article presents the technical solutions implemented during the design of the roof trusses and the elliptic skylight structure (Figure. 1) for the extension of the "Shopping City Sibiu" commercial centre in Romania. The area of the roof structure was approximately 1600 sqm (29x56
m). In the central region of the roof, a 27 m long and 10 m wide elliptic skylight was placed. The challenges of the project arouse from the relatively large span of the structure, being supported only on 13 non-symmetrically placed perimeter concrete columns. Thus, the structure had to be
designed in such a way, that it would support the extra 20 tones coming from the skylight structure, while also bring inside the natural light unobstructed by any main structural elements. The relatively large deformations between the supporting points of the skylight under variable loads
(especially snow loads) can also have adverse effects on the glazing surface during operational phase. Due to this, also the serviceability limit state checks had an important role in the engineering calculations. The structural configuration steps with performed analyses on the partial structural
models and on the complex 3D model were especially useful for the identification of the sensitive zones, helping to create the surface shape and develop adequate structural details. The paper summarizes the structural engineering challenges during the design and execution process.
Geometry and Stability: Design and Construction of a 115m Span Freeform Roof in Kuala Lumpur
Authors: Poirriez Catherine , Bouzida Yacine
Published: July 2023

Pavilion Bukit Jalil Mall is a new high-end commercial development located in Bukit Jalil, Kuala Lumpur, Malaysia. The main attraction of the mall is the piazza, an external event space covered by the Mega Canopy, a 115m span and 20 to 40m high freeform steel roof covered with ETFE,
supporting fans, lights and exhibits and providing an aerated and impressive 80m to 100m column-free space for the visitors. Although complex, the geometry was generated to fully take into account the buildability and to facilitate the fabrication of the ETFE. Many services run on the structure
- such as lighting cables, winches cables or fans cables. The structure was designed so that all the cables could be fully concealed within the columns and above the main arches to keep the services out of sight. Challenging supporting conditions made the structure highly prone to buckling
and sway. Optimization of the columns layout and height enabled to reduce the sensitivity of the structure to buckling while keeping an elegant and lightweight structure.
Case Study of Structural Design and Construction Process Analysis for an Aluminum Alloy Free Form Reticulated Shell of Nanjing Niushou Mountain
Authors: Cai Yunan , Yu Shaole , Yang Lianping , Wang Meng , Ouyang Yuanwen , Yin Jian , Lin Hui , Sun Xiaoyang , Chen Haizhou
Published: July 2023

The aluminum alloy reticulated shell structure of Nanjing Niushou Mountain, the largest single-layer aluminum alloy reticulated shell in Asia, is 227m long from south to north, 130m spanning from east to west. In the design process, the aluminum alloy reticulated shells has been established,
then the whole stability of the structure was analyzed to get the first six buckling modes and the safety factors through elastic and elastic-plastic analyses of the whole process. According to the complex construction conditions and the difficulties of construction for a super-large free
form reticulated shell, a block fabrication accompanied by step-by-step launching erection process was introduced for economical and in-site safe construction. From construction economy, four different sliding systems have been prepared and compared to enhance the construction efficiency.
Also four stages in each sliding system were assumed as their key construction steps through trial calculation and conceptual judgment. Thus, the construction process analysis model in each stage was analyzed and simulated respectively according to the key construction steps. The analysis
results show that the safety factor of the reticulated shell structure meets the requirements of the specification, and that the selected sliding construction scheme satisfies the construction requirement on the special construction condition. This report provides an effective reference on
future practical application.
Progressive Collapse Analysis of Single-Layer Latticed Domes With Fabricated Joints
Authors: Xu Ying , Zhang Xiaoning , Han Qinghua , Huang Wei , Liu Yiming
Published: July 2023

Progressive collapse accidents of single-layer latticed domes seriously threaten public safety. The progressive collapse-resisting capacity (PCRC) is gradually becoming an essential requirement in the design of spatial structures. Currently, the joint system used in spatial structures
can be divided into two categories: welded joints and fabricated joints. The semi-rigidity of fabricated joints may have a significant influence on the PCRC of single- layer latticed domes. In this study, the PCRCs of single-layer fabricated latticed domes with identical span and rise-to-span
ratio are evaluated based on the critical progressive collapse load (CPCL). The collapse mechanism of single-layer latticed domes with different grid forms is revealed by progressive analysis. In addition, the effects of joint rigidity, grid form and type of initial failure are further evaluated.
The results indicate that the collapse mechanism of single-layer latticed domes includes the radial propagation type and the circumferential propagation type. The latticed domes with quadrilateral grids have much lower PCRC than those with triangular grids. The CPCLs of weld-jointed latticed
domes are 5% to 22% higher than those of the fabricated latticed domes with the same grid form. The above influence should be fully considered in the progressive collapse-resisting design of latticed domes with fabricated joints.
HUBUNGAN PERSEPSI TERHADAP PERILAKU PENCEGAHAN AKNE VULGARIS PADA SISWA SMA
Authors: Sihombing Anggeta Daniella , Djamahar Refirman , Sartono Nurmasari
Published: July 2023

Abstrak

Akne vulgaris merupakan sebuah kelainan multifaktorial pada unit pilosebasea yang dengan tingkat keparahan terjadi pada saat usia 15-18 tahun dengan persentase 85-100% selama hidup. Pencegahan akne vulgaris sangat dibutuhkan guna meminimalkan terbentuknya akne vulgaris. Perilaku pencegahan dapat muncul dari sebuah persepsi. Persepsi ialah sebuat stimulus yang berasal dari luar dan diinterpretasikan untuk memberikan arti bagi lingkungannya. Tujuan penelitian ini ialah guna mengetahui hubungan persepsi terhadap perilaku pencegahan akne vulgaris pada siswa SMA. Penelitian dilaksanakan di SMAN 36 Jakarta pada semester genap bulan Januari-Februari 2021. Metode penelitian yang diterapkan ialah metode deskriptif dengan studi korelasional menggunakan regresi korelasi sederhana. Hasil penelitian mengungkapkan bahwa terdapat hubungan positif dan signifikan persepsi terhadap perilaku pencegahan akne vulgaris, dimana 0,292% variabel persepsi memberikan kontribusi terhadap perilaku pencegahan akne vulgaris.

Kara kunci: Persepsi, Perilaku pencegahan, Akne vulgaris

Abstract

Acne vulgaris is a multifactorial disorder in pilosebaceous units that with severity occurs at the age of 15-18 years with a percentage of 85-100% during life. Prevention of acne vulgaris is needed to minimize the formation of acne vulgaris. Preventive behavior can arise from perception. Perception is a stimulus that comes from the outside and is interpreted to give meaning to the environment. Therefore, this study aims to determine the relationship of perception to the prevention behavior of acne vulgaris in high school students. This research was conducted at SMAN 36 Jakarta on the 2nd semester, from January until February 2021. The method of this research was the descriptive method with correlational studies using simple correlation regression analysis. The results revealed that there was a positive and significant relationship of perception to the prevention behavior of acne vulgaris, where 0.292% of perception variables contributed to the prevention behavior of acne vulgaris.

Keywords: Perception, Preventive behavior, Acne vulgaris
Pengembangan Handout Biologi Berbasis Pendekatan Kontekstual Pada Materi Biologi: Studi Literatur
Authors: Ramadhani Rosi , Rahmi Yosi Laila , Fitri Rahmadhani , Selaras Ganda Hijrah
Published: July 2023

Penggunaan bahan ajar dalam proses pembelajaran yang tepat dapat meningkatkan pemahaman, minat, serta motivasi pesera didik untuk belajar. Banyak hal yang bisa dilakukan oleh guru membantu peserta didik dalam mencapai hasil belajar yang lebih baik, salah satunya  adalah pengembangan materi pendidikan seperti handout. Handout yang berdasarkan pendekatan kontekstual merupakan salah satu bahan ajar yang dapat mengaktifkan peserta didik memahami materi biologi. Penelitian ini bertujuan untuk menghasilkan handout valid yang berbasis pendekatan kontekstual pada materi biologi. Penelitian ini merupakan pengembangan dengan model pengembangan 4-D yang terdiri dari langkah-langkah mendefinisikan, merancang, mengembangkan, dan menyebarluaskan. Metode yang digunakan dalam penelitian ini adalah meta analisis dari studi literatur. Hasil dari pengembangan ini adalah menghasilkan handout  berdasarkan kriteria sangat valid dan sangat praktis.
Virtual Aquascape for Users Utilizing Augmented Reality
Authors: Aini Della Swastika Nur , Dijaya Rohman , Rahmawati Yunianita
Published: July 2023

Aquascape is the art of arranging plants in water. The large number of complaints from aquascape buyers were not up to expectations, causing sellers to have difficulty in setting an example of an orderable aquascape, so researches created an aquascape application system to increase their promotional activities with augmented reality technology accessible through smartphone. One uses the methode MDLC (Multimedia Development Life Cycle). As a result, the application can implement a markless augmented reality to display 3D objects in real time with the help of a camera on a smartphone or a trilib feature by importing 3D object files found on file managers on a smartphone. User can easily provide the desired aquascape example of the aquascape application.
Decreasing incidence of CKD/CKDu in North Central Province of Sri Lanka: is it related to provision of drinking water reverse osmosis plants?
Authors: Ranasinghe Asanga , Somatunga Lakshmi , Kumara Priyantha , Karunarathna Ranamuka , De Silva Pubudu , Gunawardena Chathurika , Kumari Champika , Sarjana Fathima , De Silva Chandu
Published: July 2023

Background
We assess the impact of provision of reverse osmosis (RO) water on the incidence of CKD/CKDu in North Central Province (NCP) of Sri Lanka.
Methods
A cross sectional survey was conducted on data from 2010–2020 on the incidence of CKD/CKDu, CKD/CKDu screening and provision of drinking water reverse osmosis (RO) plants in NCP. Analysis was conducted using descriptive statistics, ANOVA and chi-square test.
Results
The incidence of CKD/CKDu (per 100 000 population) in 2010–2013, 2014–2016 and 2017–2020 periods in Anuradhapura district were 129.07, 331.06 and 185.57 (p = 0.002) while in Polonnaruwa district these were 149.29, 326.12 and 296.73 (p = 0.04) respectively. In NCP provision of Reverse Osmosis (RO) plants commenced after 2011 and the decline in the incidence of CKD/CKDu occurred in 25 of the 29 Divisional Secretary Divisions when more than 20% of the families received access to drinking RO water projects. In both districts mean time taken to reduce the incidence rate of CKD/CKDu after reaching 20% of family coverage is 0.8 years.
Conclusions
CKD/CKDu incidence increased in NCP from 2010 to 2016 and continuously decreased thereafter. Continuous declining of CKD/CKDu incidence was observed after more than 20% of the families received access to drinking water RO plants.
The mediating effects of coping styles in the relationship between dyadic adjustment and maternal postpartum depression: a cross-sectional study
Authors: Deng Jing , Chen Jing , Guo Xiujing , Liu Fan
Published: July 2023

Background: Postpartum depression (PPD) is a major psychological matter following childbirth and may be correlated to detrimental effect for the mother, spouse, infants, and children. The risk factors for PPD among postpartum women have been studied, and yet the mechanisms of these factors are still imprecise. This study aimed to examine the direct and mediating effects of different coping styles in the relationship between the dyadic adjustment and PPD among postpartum women.
Methods: A cross-sectional study was administered to 626 delivery women who have been given birth in a tertiary hospital. Sociodemographic and obstetric data were measured by a self-developed questionnaire. The Dyadic Adjustment Scale (DAS), Simplified Coping Style Questionnaire (SCSQ), and Edinburgh Postnatal Depression Scale (EPDS) were performed to measure the marital adaptation status, coping styles, and depressive symptoms of postpartum women, respectively. Furthermore, the direct and mediating effects analysis was conducted using structural equation modeling.
Results: The prevalence of PPD was 22.6% in this study. The standardized path coefficients from the dimensions of dyadic adjustment to PPD (Dyadic consensus: β=﹣0.16, P﹤0.01, Affectional expression: β=﹣0.14, P﹤0.01, Dyadic cohesion: β=﹣0.10, P﹤0.05) achieved significance but Dyadic satisfaction (β=﹣0.06, P=0.19). Positive coping styles played a mediating role in the effect of Dyadic consensus and Dyadic satisfaction on EPDS (95% CI: − 0.036, −0.001, P﹤0.05; 95% CI: − 0.081, −0.008, P﹤0.05, respectively), negative coping style played a mediating role in the effect of Dyadic satisfaction and Dyadic cohesion on EPDS (95% CI: −0.111, −0.025, P﹤0.05; 95% CI: −0.139, −0.044, P=0.001, respectively).
Conclusion: Higher level of marital quality diluted the likelihood of PPD directly as well as indirectly through the mediating roles of coping styles. Thusly, ameliorating the quality and adjustment status of marital, employing positive coping style at once could assist to improve maternalpsychological health.
Cohort Profile: Iranian Electronic Physiology Registry (IEPR)
Authors: Nikoo Mohammad Hossein , Jorat Mohammad Vahid , Heydari Seyed Taghi , Mostafavi Sara , Fatemian Hossein , Zamani Mohammad Mohsen , Aghabozorgi Mahan , Jafari Mohammad Bagher , Karami Mohammad , Mahmoudi Masoud , Mohammadi Sina , Rahimi Maede , Yazdanpanah Reza , Kalantari Mohammad , Falahi Mohammad Reza , Jafary Ida , Namazee Mehrad , Arjangzade Alireza , Emkanjoo Zahra , Nikoo Amir Ali
Published: July 2023

Objective: Cardiac Implantable Electronic Devices have emerged as an important treatment modality in the field of electrophysiology. The use of cardiac devices including pacemakers, implantable cardioverter-defibrillators (ICDs), and cardiac resynchronization therapy (CRT), has increased significantly over the past few decades. The long-term outcomes of these devices need to be investigated.
Data description: The Iranian Electronic Physiology Registry (IEPR) will identify factors that may predispose patients to complications, long-term outcomes of cardiac devices, hospitalizations, and mortality rates.
FLEX PUF: A Flexible Physical Unclonable Function Design Using Configurable Templates
Authors: Vega Christopher , SLPSK Patanjali , Chatterjee Atri , Bhunia Swarup
Published: July 2023

Field Programmable Gate Array (FPGA) has been seen as the intersection between cost and design time when compared to ASIC and DSP. Many of the security risks present in the supply chain apply to FPGA devices, and as such, there exists a need for FPGA-based security measures. Physically Unclonable Functions (PUFs) have shown to be a promising method for authenticating and validating devices. Current works have utilized FPGAs as a method for testing ASIC PUFs or do not utilize the FPGA architecture to the benefit of the PUF, limiting its potential application.
In this work, we propose an FPGA-based PUF that takes advantage of the FPGA architecture to increase entropy. We propose a PUF that utilizes different design templates to switch out the method of entropy used to generate the PUF response. We also propose using the routing and placement constraints to further increase the entropy generated. By doing so, we can create a hybrid, strong memory-based PUF, where the placement, routing, and templates act as input challenges.
To evaluate our PUF, we analyze the responses provided by a set of different templates to evaluate their uniqueness, robustness, and uniformity. Additionally, we evaluate the entropy provided by the templates and compare it to other templates and when mapped to different areas of the FPGA. We also evaluate the security benefits of our system and provide techniques for better leveraging the performance of our PUF.