bluuebunny/crossref_metadata_2025 huggingface dataset:
Fracture Mechanism of H13 Steel During Tensile Testing Based on In Situ EBSD
Authors: Li Yunling , Ma Dangshen , Chi Hongxiao , Zhang Shulan , Zhou Jian , Cai Jin
Published: February 2025

This paper employs in situ Electron Backscatter Diffraction (EBSD) tensile technology to thoroughly consider the evolution of microstructure, grain size, grain boundary characteristics, orientation differences, and dislocation density of H13 steel during the elastic and plastic stages of room temperature tensile testing. The study unveils the deformation mechanisms of inclusions, carbides, and the matrix in H13 steel during the various stages, providing a comprehensive explanation for the slightly superior tensile properties of H13 steel when refined by Vacuum Induction Melting combined with Vacuum Arc Remelting (VIM + VAR) over those when refined by Electroslag Remelting (ESR). This discrepancy is primarily attributed to the differences in inclusions and carbides present in the two refining processes. The quantity and size of inclusions and carbides are closely related to material fracture. Large-sized carbides and inclusions were shown to be more likely to cause dislocation pile-ups and stress concentration. This, in turn, leads to faster crack initiation and propagation during plastic deformation. Conversely, the formation of micro-pores within these fine inclusions and the matrix is contingent on greater plastic deformation, resulting in a gradual and incremental linkage of these micro-pores to form dimples beneath the influence of slip.
A 64 × 64 GaN Micro LED Monolithic Display Array: Fabrication and Light Crosstalk Analysis
Authors: Xiao Yang , Meng Yuan , Feng Xiaoyu , He Longzhen , Shields Philip , Lee Sean , Wang Yanqin , Wang Zhifang , Ning Pingfan , Liu Hongwei
Published: February 2025

Monolithic micro LED display arrays show potential for application in small-area display modules, such as augmented reality (AR) displays. Due to the short distance between micro LEDs and the monolithic transparent substrate, a light crosstalk phenomenon exists between adjacent micro LED pixels, decreasing the array’s display definition. In this paper, a 64 × 64 GaN micro LED monolithic display array was fabricated on a silicon-based drive circuit. The micro LED size was 20 μm × 20 μm, and the pitch between micro LEDs was 28 μm. To suppress the optical crosstalk between adjacent micro LEDs in the array, we etched a photonic crystal structure using a focused ion beam (FIB) on the micro LED sapphire substrate. Measurements of the micro LED nearfield electroluminescence (EL) and finite element method (FEM) calculations demonstrated that the light expansion was confined in the photonic crystal micro LED with a thinner substrate. The presented work provides references regarding the fabrication of monolithic micro LED arrays and the control of crosstalk in displays.
Precision Fabrication and Optimization of Nanostructures for Exosome Detection via Surface-Enhanced Raman Spectroscopy
Authors: Wang Qingyi , Yu Bowen , Yang Bingbing , Zhang Xuanhe , Yu Guoxu , Wang Zeyu , Qin Hua , Ma Yuan
Published: February 2025

Exosome detection is crucial for biomedical research and clinical diagnostics due to their unique characteristics. Surface-enhanced Raman spectroscopy (SERS) based on nanostructure substrates with local field enhancement capability is a promising detection approach. However, the random distribution of nanostructures leads to uneven “hotspots” distribution, which limits their application in SERS detection. Here, we systematically investigated the impact of experimental parameters on nanostructure morphology and analyzed their formation mechanism, achieving controllable nanocone fabrication. Subsequent experiments confirmed the reliability and effectiveness of the fabricated nanocone in exosome SERS detection. This work not only realized flexible control of nanostructures but also expanded their application prospects in the field of exosome analysis.
Cannabinoid-2 Receptor Activation Attenuates Sulfur Mustard Analog 2-Chloroethyl-Ethyl-Sulfide-Induced Acute Lung Injury in Mice
Authors: Nicholson Gregory , Richards Nicholas , Lockett Janette , Ly My Boi , Nair Raj V. , Kim Woong-Ki , Vinod K. Yaragudri , Nagre Nagaraja
Published: February 2025

Background: Exposure to sulfur mustard (SM; 2,2′-dichlorodiethyl sulfide) causes toxicity in the human body, particularly the lungs. The molecular mechanisms of SM-induced lung damage are elusive, and no effective treatments exist. This study explores the anti-inflammatory potential of cannabinoid receptor 2 (CB2R) activation in mitigating acute lung injury (ALI) and inflammation induced by 2-chloroethyl ethyl sulfide (CEES), a structural analog of SM. Methods: C57BL/6J mice were exposed to CEES via intratracheal administration to model ALI. CB2R activation was achieved through the intraperitoneal administration of HU308, a selective synthetic agonist. ALI and inflammation were evaluated at 48 h post-exposure to CEES. Bronchoalveolar lavage fluid (BALF) was collected to measure total cells, protein, and cytokines. Lung injury, inflammatory signaling in alveolar macrophages (AMs), and matrix metalloproteinase-9 (MMP-9) activity were assessed via histological analysis, immunoblotting, and gelatin zymography, respectively. Results: CEES exposure led to an increase in immune cell infiltration, pro-inflammatory cytokines (IL-6 and TNF-α), and pro-MMP9 levels in the BALF, which were significantly decreased by HU308 treatment. The activation of CB2R attenuated CEES-induced NF-κB activation and reduced pro-inflammatory M1 markers (iNOS, and Cox-2) but did not alter the increase in the M2 marker arginase-1. CB2R activation mitigated CEES-induced oxidative stress, as evidenced by lower levels of heme oxygenase-1 (HO-1) and reactive oxygen species (ROS) in mouse AMs. Additionally, 4-hydroxynonenal (4-HNE) levels were reduced in the lungs of HU308-treated mice but were elevated after CEES exposure. Conclusions: These findings suggest that CB2R activation alleviates CEES-induced ALI and inflammation in mice, supporting its potential as a therapeutic approach for vesicant-induced pulmonary injury.
Development, Safety, and Therapeutic Evaluation of Voriconazole-Loaded Zein–Pectin–Hyaluronic Acid Nanoparticles Using Alternative In Vivo Models for Efficacy and Toxicity
Authors: Fin Margani Taise , dos Santos Kelvin Sousa , Gualque Marcos William de Lima , dos Santos Rafaela Cristine , Aoki Natália Cristina Morici , Auler Marcos Ereno , Fusco-Almeida Ana Marisa , Mendes-Gianinni Maria José Soares , Mainardes Rubiana Mara
Published: February 2025

Background/Objectives: Fungal infections caused by Candida species remain a significant clinical challenge, exacerbated by limitations in current antifungal therapies, including toxicity and poor bioavailability. This study aimed to develop and evaluate voriconazole-loaded zein–pectin–hyaluronic acid nanoparticles (ZPHA-VRC NPs) as a novel drug delivery system to enhance efficacy and reduce toxicity. Alternative in vitro and in vivo models were utilized to assess the safety and therapeutic potential of the nanoparticles. Methods: ZPHA-VRC NPs were prepared using a nanoprecipitation method and characterized for particle size, polydispersity index, zeta potential, and encapsulation efficiency. Antifungal activity was assessed via MIC assays against Candida albicans, C. krusei, and C. parapsilosis. Cytotoxicity was evaluated on Vero cells, while in vivo toxicity and efficacy were assessed using Galleria mellonella and Caenorhabditis elegans models. The therapeutic efficacy was further evaluated in an infected Caenorhabditis elegans model using survival and health scores. Results: ZPHA-VRC nanoparticles exhibited favorable physicochemical properties, including a particle size of approximately 192 nm, a polydispersity index of 0.079, a zeta potential of −24 mV, and an encapsulation efficiency of 34%. The nanoparticles retained antifungal activity comparable to free voriconazole while significantly reducing cytotoxicity. In vivo studies using G. mellonella and C. elegans demonstrated that ZPHA-VRC NPs markedly improved survival rates, reduced fungal burden, and enhanced health scores in infected models, outperforming the free drug. Additionally, the nanoparticles exhibited a superior safety profile, minimizing systemic toxicity while maintaining therapeutic efficacy. Conclusions: ZPHA-VRC NPs offer a safer and more effective delivery system for VRC, addressing the limitations of conventional formulations. The integration of alternative efficacy and safety models highlights their value in preclinical research.
Multifunctional Roles and Ecological Implications of Nano-Enabled Technologies in Oryza sativa Production Systems: A Comprehensive Review
Authors: Zhao Wei , Wang Ting , Dong He , Zhao Wanru , Song Kai , Zhu Nina
Published: February 2025

Micro–nanomaterials have garnered significant attention in rice (Oryza sativa L.) cultivation due to their unique physicochemical properties. This study reviews the multifunctional applications of micro–nanomaterials in enhancing rice resilience, promoting nutrient uptake, improving photosynthetic efficiency, and increasing the utilization rates of fertilizers and pesticides. Using keyword and clustering analyses, this review identifies key research hotspots and emerging trends in the field, including heavy metal stress, nanoplastic pollution, and biochar applications. While early studies predominantly focused on the synthesis and characterization of these materials, recent research has shifted towards evaluating their comprehensive ecological impacts on rice production systems. Despite the promising potential of micro–nanomaterials in improving rice yield and quality while supporting sustainable agriculture, concerns about their long-term accumulation in ecosystems and potential toxicity remain unresolved. Future research should prioritize the development of cost-effective, efficient, and environmentally friendly micro–nanomaterials and establish standardized frameworks for ecological risk assessments to facilitate their large-scale agricultural application. This study provides theoretical insights and practical references for advancing micro–nanotechnology in global food security and sustainable agriculture.
Integrative Trait Analysis for Enhancing Heat Stress Resilience in Tomato (Solanum lycopersicum L.): A Focus on Root, Physiological, and Yield Adaptations
Authors: Mohammed Sharukh Pasha , Yen Jo-Yi , Hsu Yun-Che , Chou Hsiu-Yi , Natarajan Sritharan , Eybishitz Assaf
Published: February 2025

Tomato (Solanum lycopersicum L.) is an economically important crop worldwide, particularly in tropical and subtropical regions. However, production is significantly and increasingly affected by the impacts of climate change, including heat and drought stress and emerging pests and diseases. This study specifically evaluated the effects of heat stress on root and shoot morphology, photosynthesis, and yield traits in five tomato genotypes, to identify the characteristics that differentiate heat tolerance from susceptibility. Heat stress experiments were conducted in a polyhouse, one during the summer under high temperatures, with a non-stress trial during the winter under conducive natural conditions. Significant reductions in yield, root traits and photosynthesis were observed across all genotypes under heat stress. However, the genotype MG785-1 maintained a relatively higher yield (298.01 ± 25.1 g), a 37.7% reduction compared to non-stress conditions, while CLN4786F1 showed resilience with a 32.3% decrease compared to its non-stress harvest index. Root dry weight (5.91 ± 0.53 g in MG785-1) and root shoot ratio (0.19 ± 0.01 in MG785-1) were identified as key traits for heat tolerance. Physiological traits, such as photosynthetic rate (11.71 ± 1.61 µmol CO2 m−2 s−1 in MG785-1), were critical for maintaining growth under heat stress. In contrast, the heat-sensitive genotype CLN3961D exhibited a significant decline in yield and physiological performance. Root dry weight and root to shoot ratio were key indicators for heat tolerance, while the photosynthetic rate was critical for maintaining plant growth under stress. These findings underscore the importance of integrated root and physiological traits, providing valuable insights for breeding climate-resilient tomato varieties.
Effect of Reservoir Transformation on Fracture Expansion in Deep Coalbed Methane Reservoirs and Mechanism Analysis
Authors: Liu Jun , Zhang Qinghua , Fan Yanyang
Published: February 2025

This paper proposed a fracture propagation model of water-based fracturing based on seepage–stress–damage coupling, which was employed to analyse the effects of different water-based fracturing fluid properties and rock parameters on the propagation behaviour of reservoir fractures in low-permeability reservoirs. Concurrently, molecular dynamics theory and mechanical analysis of reservoir fractures were employed to elucidate the microscopic mechanism of water-based fracturing on fracture propagation. The results showed that the apparent viscosity of water-based fracturing fluid primarily contributed to elevated fracture internal pressures through the seepage reduction in water-based fracturing fluid at the coal fracture surface. A substantial impact on the minimum fracturing pressure of coal fractures that rapidly pierce the coal rock and an increasing crack extension was notably presented by the low filtration and high viscosity of water-based fracturing fluids. Furthermore, the reservoir pressure and the crack turning angle were not conducive to the effective expansion of coal seam fractures, whereas the reservoir temperature exhibited a positive proportional relationship with deep coal seam fractures.
Optimisation and Comparison of Markerless and Marker-Based Motion Capture Methods for Hand and Finger Movement Analysis
Authors: Maggioni Valentin , Azevedo-Coste Christine , Durand Sam , Bailly François
Published: February 2025

Ensuring the accurate tracking of hand and fingers movements is an ongoing challenge for upper limb rehabilitation assessment, as the high number of degrees of freedom and segments in the limited volume of the hand makes this a difficult task. The objective of this study is to evaluate the performance of two markerless approaches (the Leap Motion Controller and the Google MediaPipe API) in comparison to a marker-based one, and to improve the precision of the markerless methods by introducing additional data processing algorithms fusing multiple recording devices. Fifteen healthy participants were instructed to perform five distinct hand movements while being recorded by the three motion capture methods simultaneously. The captured movement data from each device was analyzed using a skeletal model of the hand through the inverse kinematics method of the OpenSim software. Finally, the root mean square errors of the angles formed by each finger segment were calculated for the markerless and marker-based motion capture methods to compare their accuracy. Our results indicate that the MediaPipe-based setup is more accurate than the Leap Motion Controller-based one (average root mean square error of 10.9° versus 14.7°), showing promising results for the use of markerless-based methods in clinical applications.
A Sub-Pixel Measurement Platform Using Twist-Angle Analysis in Two-Dimensional Planes
Authors: Lyu Jiangbo , Kong Wenchao , Zhou Yan , Pi Yazhi , Cao Zizheng
Published: February 2025

Arrayed ultraviolet (UV) LED light sources have been widely applied in various semiconductor processes, ranging from photopolymerization to lithography. In practical cases, based on data provided by manufacturers, calibration of individual UV LEDs is often needed before their real usage in high-precision applications. In this paper, we present a high-precision, automated light source measurement platform, which can be applied to the performance evaluation of various types of light sources. In order to minimize errors introduced by the automated measurement system, the platform employs a sub-pixel measurement technique, along with a twist-angle method, to perform multiple measurements and analyses of the spatial intensity distribution of the light source on a given plane. Through noise analysis of repeated measurements, the platform’s effectiveness and reliability are validated within a certain tolerance range. The high-precision automated light source measurement platform demonstrates excellent performance in the precise control and data acquisition of complex light sources. The light source dataset derived from the test results can provide guidance for the optimization of light sources in fields such as lighting, imaging, and lithography.
Quantitative and Narrative Analysis of Dump Truck-Related Injuries and Fatalities in the United States
Authors: Bunn Terry L. , Northcutt Caitlin A. , Honaker Rebecca , Maloney Patrick
Published: February 2025

Dump truck safety recommendations have been implemented by companies, but a comprehensive study of risk factors associated with dump truck injuries and fatalities has not been performed. Published research specifically focusing on dump truck injuries is limited. The purpose of this descriptive study was to characterize risk factors associated with dump truck-related inspection cases reported by the OSHA in the United States. Dump truck inspections during 2016–2020 were obtained from the online OSHA IMIS database. Pearson’s chi-square test and logistic regression were performed. An intraclass correlation coefficient (ICC) using PROC MIXED and a generalized linear mixed model was calculated on 122 closed dump truck-related inspection cases. One half of dump truck worker fatalities resulted in a serious OSHA violation, whereas three quarters of nonfatal dump truck worker injuries resulted in an ‘other’ or no OSHA violation; 22% of fatalities involved the dump truck backing up. A nonfatal injury narrative often involved the words ‘finger’, ‘tailgate’, and ‘bed’, whereas the words ‘trailer’, ‘asphalt’, ‘load’, and ‘loader’ were mentioned more often in fatalities. A fatal dump truck injury was three times more likely to be associated with a serious OSHA violation compared to a nonfatal dump truck injury. Industries should provide initial and refresher worker safety training to dump truck drivers and other employees who work within the dump truck hazard zone, particularly employees who utilize dump trucks for working with asphalt or around power lines, and employees who repair dump trucks.
How Does Digital Inclusive Finance Affect Agricultural Green Development? Evidence from Thirty Provinces in China
Authors: Sun Hong , Li Wenjing , Guo Xue , Wu Ziyue , Mao Zimo , Feng Jun
Published: February 2025

The report of the 20th National Congress of the Communist Party of China has proposed to promote green development, which is an important concern in realizing agricultural green development (AGD). Based on the connotations of AGD, the mechanism of the impact of digital inclusive finance on AGD is explored from the perspective of agricultural technology innovation, agricultural production socialization services and rural industry integration. Using the spatial Durbin model from 2011 to 2021, the regional development differences in AGD are analyzed. The results are as follows. (1) The level of AGD in the eastern region is relatively high, and the regional distribution pattern of “east–middle–west” is generally formed from high to low. (2) In terms of the mechanism of action, digital inclusive finance has an impact on AGD, mainly by promoting agricultural technological innovation, improving the level of socialized services of agricultural production and promoting the integrated development of rural industries. (3) When the intensity of environmental regulation is high, the promotional effect of digital inclusive finance on AGD is greater, while, when environmental regulation is weak, the promotional effect of digital inclusive finance on AGD is small. When more attention is paid to AGD, the impact of digital inclusive finance on AGD is stronger; when the emphasis on AGD is small, the impact of digital inclusive finance on AGD is weaker. (4) The higher the level of AGD, the greater the role of digital inclusive finance in promoting AGD, and the impact in the eastern region is greater than that in the central and western regions.
Sustainable Tourism Development in Mountain Regions: A Case Study of Peștera Village, Brasov County, Applying the Analytic Hierarchy Process
Authors: Gherdan Alina Emilia Maria , Bacter Ramona Vasilica , Maerescu Cristina Maria , Iancu Tiberiu , Ciolac Ramona , Ungureanu Alexandra
Published: February 2025

This study applied the Analytic Hierarchy Process (AHP) to determine the priority criteria for sustainable tourism development in Peștera Village, focusing on six essential areas: Environmental Sustainability, Economic Benefits, Cultural and Social Preservation, Infrastructure and Accessibility, Tourism Experience and Satisfaction, and Policy and Regulation Compliance. The AHP analysis demonstrated that Environmental Sustainability emerged as the top priority, emphasizing the need for tourism practices that preserve the village’s natural environment and ecosystems. Economic Benefits closely followed, highlighting the community’s recognition of tourism as a crucial driver for local economic growth, job creation, and income generation. The combination of these two criteria indicates a clear alignment between ecological preservation and the village’s economic aspirations, which are both fundamental to achieving long-term sustainable development. This research contributes to an improved understanding of sustainable practices in mountain tourism, offering insights applicable to similar tourism regions. By aligning environmental, economic, and cultural priorities, this study supports the development of comprehensive policies aimed at fostering resilience and sustainability in mountain tourism destinations worldwide.
Research Hotspots and Evolution Trends of Port Emission Reduction: A Bibliometric Analysis Based on CiteSpace
Authors: Yuan Kebiao , Ma Lina , Wang Renxiang
Published: February 2025

As a key node in the transportation network, ports connect the inland hinterland with the outside world, providing strong guarantees for the sustainable development of domestic trade and economy. However, the increasing port activities, while promoting regional economic growth, have also brought increasingly serious environmental problems to the local area. Promoting port emission reduction is a key way and important lever for China’s transportation industry to promote ecological civilization construction. By using CiteSpace to systematically review the literature on port emission reductions in recent years in the China National Knowledge Infrastructure (CNKI) and Web of Science databases, it was found that significant achievements have been made in port emission reduction technology, policy system construction, and emission reduction effect evaluation. However, there are still problems such as insufficient research on regional differences and insufficient in-depth analysis of emission reduction costs and benefits. Analyzing the hotspots and trends of port emission reduction research at home and abroad can provide reference for the theoretical research and practical path of coordinated emission reduction governance in Chinese ports. Future research on port emission reduction should focus on regional differences, cost–benefit analysis, and in-depth exploration of the synergistic effects of port emission reduction and regional economic development, in order to provide more comprehensive theoretical support and practical guidance for the green sustainable development of ports.
Current State of Greenhouse Waste Biomass Disposal Methods, with a Focus on Essex County Ontario
Authors: Jadischke Robyn , Lubitz William David
Published: February 2025

Managing organic waste produced from agricultural greenhouse production is becoming an increasing concern for growers and communities that contain significant greenhouse production. Currently, in North America, the waste vines, leaves and stems, and fruit grade-outs that are produced during in-season greenhouse production and post-harvest processes are most commonly sent to local landfills. With landfills rapidly filling and increasing pressures to improve the sustainability and circularity of greenhouse production, alternative waste management solutions are needed. This review examines greenhouse organic waste characteristics and composition, focusing on Essex County, Ontario, Canada, which has the highest density of greenhouse production in North America. Current worldwide research on greenhouse waste disposal methods is reviewed, including landfilling, land application, incineration and waste-to-energy, anaerobic digestion, char production, organic fertilizer production and composting, and insect digestion. Seasonal timing, waste composition, cost, space, and the state of research influence the feasibility of implementing these solutions on an industrial scale. This review also contains a case study of greenhouse organic waste characteristics and quantity, and the most suitable management strategies for Essex County (containing the Leamington and Kingsville areas) in southern Ontario, Canada, where this issue is becoming an increasing concern to the local community. Gaps in policy and data are highlighted, including barriers that may limit the adoption of the innovative solutions proposed.
Weather-Driven Cycling: Developing a Predictive Model for Urban Bicycle Usage Based on Five Key Weather Factors
Authors: Falah Nahid , Falah Nadia , Solis-Guzman Jaime
Published: February 2025

Weather conditions significantly influence urban cycling, shaping both its frequency and intensity. This study develops a predictive model to evaluate the impact of five key meteorological factors, namely temperature, humidity, precipitation, wind speed, and daylight duration, on urban cycling trends. Using non-linear regression analysis, the research examines cycling data from 2017 to 2019 in Hamburg, Germany, comparing predicted values for 2019 with actual data to assess model accuracy. The statistical analyses reveal strong correlations between weather parameters and cycling activity, highlighting each factor’s unique influence. The model achieved high accuracy, with R2 values of 0.942 and 0.924 for 2017 and 2019, respectively. To further validate its robustness, the model is applied to data from 2021 and 2023—years not included in its initial development—yielding R2 values of 0.893 and 0.919. These results underscore the model’s reliability and adaptability across different timeframes. This study not only confirms the critical influence of weather on urban cycling patterns, but also provides a scalable framework for broader urban planning applications. Beyond the immediate findings, this research proposes expanding the model to incorporate urban factors, such as land use, population density, and socioeconomic conditions, offering a comprehensive tool for urban planners and policymakers to enhance sustainable transportation systems.
Systolic Pulmonary Artery Pressure as Long-Term Mortality Predictor in Elderly Critically Ill with Severe COVID-19 Pneumonia
Authors: Kurnik Marko , Božič Helena , Podbregar Matej
Published: February 2025

Background: COVID-19 can cause acute pulmonary hypertension (PH), worsening outcomes in critically ill elderly patients. Point-of-care ultrasound (POCUS), assessing right ventricular hemodynamics, predicts short-term outcomes. This study examines the long-term impact of acute PH on mortality in elderly COVID-19 patients. Methods: This retrospective long-term study analyzed data from patients over 70 years old with severe COVID-19 pneumonia admitted to a mixed 25-bed, level 3 intensive care unit (ICU). POCUS focused on systolic pulmonary artery pressure (sPAP) at admission. Mortality was evaluated 1000 days post-admission. Results: The study included 130 patients, comprising 30 long-term survivors and 100 non-survivors, with a cumulative long-term mortality rate of 77%. Non-survivors had significantly higher sPAP values (39.1 ± 12.8 vs. 30.4 ± 9.2, p = 0.04), which were associated with long-term mortality in survival analysis. Conclusion: Acute pulmonary hypertension (PH), reflected by elevated systolic pulmonary artery pressure (sPAP), is strongly associated with long-term mortality in elderly critically ill COVID-19 patients. Early assessment of sPAP via POCUS may help identify high-risk patients and guide management strategies to improve outcomes.
The Humoral Immune Response Against COVID-19 Through Vaccination in Hemodialysis Patients
Authors: Park Ji Young , Choi Seong-Ho , Lim Yong Kwan , Shin Jungho , Kwon Soie , Kim Haein , Chung Jin-Won
Published: February 2025

Background: This study investigated the humoral responses to SARS-CoV-2 in hemodialysis (HD) patients. The clearance of molecules in the blood during hemodialysis is influenced by factors such as filter pore size, flow rate, operating pressure, and treatment duration. Chronic kidney disease patients often show low antibody titers for pathogens like pneumococcus, influenza virus, and hepatitis B virus. Methods: In this study, the surrogate virus neutralization test (sVNT) for the wild type (WT) and Omicron variants, as well as spike-specific IgG levels, were measured at two time points (May 2022 and December 2023). Medical records and questionnaires were used to gather participant information. Results: A total of 26 HD patients were enrolled, including 3 on immunosuppressive therapies. A total of 8 patients had COVID-19 during the first sampling, and 19 during the second. The results showed that sVNT levels for WT decreased over time, though positivity remained at 100% during both sampling periods. In contrast, sVNT levels for Omicron increased significantly, with positivity rising from 46.2% to 75.0% (p < 0.05). Spike-specific IgG levels also increased, with positivity improving from 96.2% to 100%. Patients on immunosuppressive therapies had significantly lower sVNT levels for both WT and Omicron in the second period (p < 0.05), though no significant differences were observed during the first period. Conclusion: HD patients, particularly those on immunosuppressive therapies, showed reduced and declining neutralizing responses over time. A meta-analysis of HD patients seems necessary to determine whether all dialysis patients need COVID-19 booster vaccinations, similar to the hepatitis B vaccine, highlighting the need for targeted vaccination strategies.
Uso de las tecnologías de la información y la comunicación en estudiantes de educación básica de Lima, Perú
Authors: Sánchez Bello Silvia Graciela
Published: February 2025

La Tecnología de la Información y la Comunicación (TIC) aplicada en el aprendizaje utiliza una amplia gama de herramientas, dispositivos y plataformas digitales que facilitan la comunicación, la colaboración, el acceso a la información y la creación de conocimientos. El estudio tuvo como objetivo conocer el nivel de aplicación de la TIC en estudiantes de educación básica regular. El estudio ha sido de tipo básico, de nivel descriptivo y enfoque cuantitativo, con un diseño no experimental. La técnica ha sido la encuesta aplicando un cuestionario de 45 ítems en una muestra de 90 estudiantes. Según los resultados, el nivel de uso de las TIC ha sido regular para el 61.1% de los encuestados, por lo que se concluye que se requiere una intervención para la mejora del uso de las TIC en la Institución Educativa Santísima Cruz de San Martin de Porres, de Lima
Infidelidad virtual, violencia, resiliencia y rendimiento académico en estudiantes universitarios
Authors: Ojeda Reto Marcos Germain
Published: February 2025

Explorando la intersección entre infidelidad virtual, violencia, resiliencia y rendimiento académico, este artículo analiza las complejidades que enfrentan los estudiantes universitarios en su vida cotidiana. Para ello, se realizó un estudio instrumental y correlacional. La participación en el estudio abarcó una muestra de 101 estudiantes universitarios. Se usaron como instrumentos el Cuestionario de Violencia Entre Novios (CUVINO), el Cuestionario de la Escala de Percepción de la Infidelidad en las Redes y la Escala de Percepción de Infidelidad en Redes Sociales. Los resultados evidencian que el modelo M3 es capaz de explicar el 94.13% de la variabilidad de los datos, y, por tanto, establecer que el conjunto de las tres variables independientes (violencia de pareja, infidelidad en redes sociales y resiliencia) poseen una relación estadísticamente significativa con el desempeño académico. El estudio destaca la importancia de abordar la violencia, infidelidad y resiliencia, dada su notable influencia en las actividades académicas
Competencia digital y actitudes hacia el cambio: Perspectivas de estudiantes en universidades nacionales de Lima
Authors: Simangas Villalobos Aram Roosell , Collazos Roque Edith Geovana , Abregú Anchayhua Cielo del Carmen , Gonzales Mirarda Jorge Antonio , Zorrilla Esparza Cesar Jhonny
Published: February 2025

El estudio analiza la relación entre la gestión de calidad, la competencia digital y la actitud hacia el cambio en usuarios de una universidad nacional de Lima, considerando la importancia de estos factores en el contexto educativo actual. El objetivo fue determinar la relación entre estas variables y sus dimensiones clave. Se utilizó un diseño cuantitativo, no experimental, de alcance correlacional, aplicándose la prueba de Friedman para evaluar la significancia estadística. Los resultados evidenciaron una relación significativa entre las variables (p = 0.000), destacando que la competencia digital influye en la actitud hacia el cambio, tanto en términos de temor como de aceptación. Asimismo, se identificó que la predisposición al cambio fortalece los procesos organizacionales. Se concluyó que la mejora en las competencias digitales y el fomento de actitudes positivas hacia el cambio son esenciales para fortalecer la gestión de calidad en las universidades, contribuyendo a su desarrollo institucional.
Competencia digital y el desarrollo profesional docente: Revisión sistemática
Authors: Vidal Castillo Delia María , Vásquez Vilela Roxana , Huarcaya Valentin Juan Feliciano , Carpio Mendoza Janet
Published: February 2025

Las competencias digitales tienen fines educativos que contribuyen el desarrollo profesional docente. La necesidad por optimizar los resultados académicos ha generado implementar las competencias digitales en el proceso de enseñanza y aprendizaje en la educación superior. El objetivo fue analizar la competencia digital y el desarrollo profesional de la educación superior. La metodología fue de revisión sistemática de la base de datos en ProQuest y ExLibris. La búsqueda se realizó con el método PRISMA, en cuanto al criterio de inclusión se consideraron estudios completos y con accesos libres, investigaciones entre los años 2021 y 2022. Respecto al criterio de exclusión se seleccionaron los artículos de revisión sistemática, estudios incompletos, investigaciones de otros años y estén publicados en inglés; conforme a ello se seleccionaron y analizaron 13 artículos. En el resultado se evidenció que las competencias digitales y el desarrollo profesional docente fortalecen las labores educativas y las prácticas pedagógicas; es así que las actividades tecnológicas promueven el uso y aplicación de las competencias digitales.
IMPLEMENTATION OF GOOD CORPORATE GOVERNANCE (GCG) AND RISK MANAGEMENT ON BANKING FINANCIAL PERFORMANCE ITS IMPACT ON COMPANY VALUE AS AN INTERVENING VARIABLE (Empirical Study On PT. Bank Negara Indonesia (Persero) Tbk Listed On The Indonesia Stock Exchang
Authors: Novriyani Novriyani , Irawati Irawati , Suwaji Suwaji
Published: February 2025

This study aims to Implementation of Good Corporate Governance (GCG) and Risk Management on Banking Financial Performance Its Impact on Company Value as an Intervening Variable (Empirical Study at PT. Bank Negara Indonesia (Persero) Tbk Listed on the Indonesia Stock Exchange (IDX) Period 2016-2023). This type of research uses Primary Data and Secondary Data with qualitative and quantitative research methods. Related to qualitative data in the form of descriptive data analyzed from items related to GCG. While quantitative data is taken from the financial statements listed on PT. Bank Negara Indonesia (Persero) Tbk. The results of this study indicate that the results of testing and discussion related to the Implementation of Good Corporate Governance (GCG) and Risk Management on Banking Financial Performance Its Impact on Company Value as an Intervening Variable both partially and simultaneously have a positive and significant effect and some have a negative and insignificant effect.
THE INFLUENCE OF COMPETENCE AND JOB SATISFACTION ON LECTURER PERFORMANCE ISLAMIC RELIGIOUS STUDIES COLLEGE (STAI) IN INDRAGIRI HULU REGENCY THROUGH SPIRITUAL MOTIVATION
Authors: Triyono Aris , Rahayu Tri
Published: February 2025

The performance of STAI lecturers in Indragiri Hulu Regency, the phenomenon seen from the results of the lecturer's tridharma, is not optimal. Many factors affect the performance of lecturers in this study, the researcher limits the research variables, namely competence, job satisfaction and mediating variables of spiritual motivation. With the aim of the study, namely to analyze the influence of competence on spiritual motivation, job satisfaction on spiritual motivation, competence on lecturer performance, job satisfaction on lecturer performance, spiritual motivation on lecturer performance, competence on lecturer performance through spiritual motivation, job satisfaction on lecturer performance through spiritual motivation. The type of research is quantitative. Primary data, the number of samples is 115 lecturers. The method used to analyze the data is a quantitative method, namely path analysis, correlation coefficient, determination coefficient, F test and T test. The results of the study are as follows, Competence affects spiritual motivation, Job satisfaction does not affect spiritual motivation, Competence affects lecturer performance, Job satisfaction does not affect lecturer performance, Spiritual motivation does not affect lecturer performance, Competence Through Spiritual Motivation does not affect Lecturer Performance, Job satisfaction Through Spiritual Motivation does not affect Lecturer Performance, STAI in Indragiri Hulu Regency.
The application of double balloon enteroscopy in diagnosis and management of small bowel bleeding
Authors: Nguyen Thi Huyen Thuong , Tran Duy Khiem , Truong Xuan Long , Tran Van Huy
Published: February 2025

Background: Small bowel bleeding is a common condition among patients with gastrointestinal bleeding with unknown origin, nonspecific findings of this condition may lead to delay in diagnosis and management. Double balloon enteroscopy (DBE) is an innovative modality that enabled physicians to identify the etiology and perform the techniques of hemostasis. Data about the role of DBE in diagnosis and intervention in small bowel bleeding in Viet Nam is still limited.

Methods and materials: 36 patients with small bowel bleeding undergoing double balloon enteroscopy (DBE) from January 2014 to June 2024 were included.

Results: The overall diagnostic yield of DBE in small bowel bleeding was 77.8%. The most common findings were angiopathy (46.3%), ulcers (32.1%). 12/28 patients received endoscopic therapy for small bowel bleeding (42.9%). Technical success was achieved in all patients and no complications was recorded during follow-up.

Conclusion: Double balloon enteroscopy is a safe and highly effective in management of small bowel bleeding.

Key words: gastrointestinal bleeding, small bowel bleeding, double balloon enteroscopy.
The relationship between blood eosinophils and hospital length of stay in patients with COPD acute exacerbation
Authors: Van Thi Minh An , Tran Thi Tra Giang
Published: February 2025

Background: Airway inflammation, identified by blood eosinophil, is a characteristic of COPD acute exacerbation. Realizing the impact of eosinophil on identifying airway inflammation among patients hospitalized for acute COPD exacerbation.

Objectives: 1. To describe the clinical and paraclinical characteristics of patients with COPD acute exacerbation. 2. To evaluate the relationship between blood eosinophils and the hospital length of stay of patients with COPD acute exacerbation.

Materials and methods: Cross-sectional study with 100 patients who had COPD and were admitted to the hospital due to COPD acute exacerbations.

Results: Patients who had blood eosinophils of < 2% had longer hospital length of stay compared to patients with a high eosinophil count of ≥ 2% (9.77 and 8.26 days respectively) (p < 0.05). The length of stay of patients who had blood eosinophil count of < 100/µL, 100 - 300/ µL, and > 300/ µL was 10.07 days, 8.95 days, and 7.04 days (p < 0.01).

Conclusion: There was an association between low blood eosinophils and longer hospital length of stay.

Key words: COPD, COPD acute exacerbation, blood eosinophils, hospital length of stay.
Officials’ promotions in the Teutonic Order in XIII – early XVI c.: visualization approach applying
Authors:   Tomsk State University, Kotov A. S.
Published: February 2025

The article is devoted to tracking career in the Teutonic Order in the 13th to early 16th centuries. The author problematizes the institutional approach to describing the hierarchical ladder of officials in medieval commune and raises the question of the identification of sustainable promotion that may define the hierarchical ladder in the Order. The study is based on network analysis. A directed weighted graph adjacency matrix describing promotions from one position to another is designed using secondary sources – prosopography charts, and then a directed graph is visualized by Gephi. The paper proposes sustainable promotions paths and the author suggests an interpretation for the promotion reasons.
Amor sostenible: analizando el brand engagement de empresas orgánicas entre los centennials ecuatorianos
Authors: Torres Aguas Karelys Yamileth , Santistevan Landin Jaden Abraham , Bonisoli Lorenzo
Published: February 2025

El presente estudio investigativo tiene como finalidad analizar el amor de marca de las empresas orgánicas a través de la medición de brand engagement. Para alcanzar este objetivo, se realizaron estudios mediante encuestas usando preguntas descriptivas con escala de Likert de 5 puntos para adquirir fundamentos sólidos para asistir a las marcas, y perfeccionar sus estrategias de marketing sostenible para tener relaciones con sus clientes a largo plazo. Además, el método de muestra empleada fue no probabilística por conveniencia, siento útil para la recopilación de los datos que se obtendrán de los centennials ecuatorianos. Asimismo, se utilizó el modelo de ecuaciones estructurales como la técnica estadística y un enfoque que se basa en covarianza. Los resultados de la investigación señalan que, aunque las personas si se preocupan por el impacto ambiental de la actividad humana, no entienden las consecuencias de la desinformación, la falta de educación y cultura. Además, las personas señalaron confiar en las cualidades de los productos orgánicos, pero no opinan lo mismo de las empresas porque existe la incertidumbre por la carencia de compromiso en un segmento más sostenible.
Big Data como instrumento integrador de datos para la toma de decisiones en la prevención, detección y tratamiento de enfermedades en el Ecuador
Authors: CAICEDO GOYES FABIAN LIZARDO
Published: February 2025

El incremento de enfermedades de diferentes patologías en el Ecuador ha impulsado la necesidad de estrategias innovadoras. En este contexto, la Big Data emerge como una herramienta clave, ofreciendo la capacidad de integrar datos polimórficos de diversas fuentes para mejorar la toma de decisiones en salud. El presente estudio propuso analizar el impacto de la Big Data en la
prevención, detección y tratamiento de enfermedades en el contexto ecuatoriano, con el objetivo de profundizar en la comprensión de cómo la integración de datos puede ofrecer una visión holística de la salud poblacional. Se buscó identificar cómo esta integración puede potenciar la eficacia de las intervenciones médicas. La investigación se basó en un análisis exhaustivo de estudios de caso, implementaciones exitosas y desafíos encontrados en la aplicación de la Big Data en el sistema de salud ecuatoriano. Se examinaron datos polimórficos, incluyendo registros médicos, datos genómicos y ambientales, para evaluar su impacto en la toma de decisiones. En conclusión, la implementación de la Big Data en la gestión de enfermedades en el Ecuador representa un avance significativo. Este artículo subrayó la importancia de integrar tecnologías digitales para avanzar hacia un enfoque más preventivo y personalizado en la atención médica ecuatoriana.
Control de reiterancia delictiva: reincidencia
Authors: Cristobal Jiménez Martin Jesus
Published: February 2025

El presente trabajo analiza los diferentes pronunciamientos respecto al instituto de la reincidencia a fin de identificar cada uno de los elementos que configuran dicho instituto. El objetivo es establecer los elementos necesarios para configurar la reincidencia, en la actualidad, en el marco de la ley vigente. Para ello, se analiza de manera exhaustiva la interpretación que se le da a dicho instituto para su configuración, en cuanto a la concurrencia de una pena privativa de libertad de carácter efectiva, la excarcelación del agente del establecimiento penitenciario en el que se encontraba internado, así como los pronunciamientos que ratifican la constitucionalidad del instituto de la reincidencia.
La incautación como instrumento de búsqueda de pruebas en los delitos contra la administración pública
Authors: Fernandez Vasquez Marcelo Alejandro
Published: February 2025

La incautación, en virtud del Acuerdo Plenario n.° 05-2010/-CJ-116 de la Corte Suprema de Justicia del Perú, se divide en (a) incautación con fines probatorios o instrumental (artículo 218 del Código Procesal Penal); y, en (b) incautación con fines de coerción o cautelar (artículo 316 del Código Procesal Penal). En las investigaciones fiscales por delitos contra la administración pública, resulta de vital importancia saber utilizar y distinguir ambas formas de incautación, pues cada caso fiscal tiene hechos y particularidades distintas. En el presente artículo de investigación, se analizará y profundizará sobre la incautación con fines probatorios como un instrumento eficaz en las investigaciones fiscales por delitos contra la administración pública. Asimismo, se desarrollará el procedimiento a seguir y los principales escenarios problemáticos que pueden suscitarse en su utilización; por ejemplo, la distinción entre una entrega voluntaria de una incautación, si ante todo bien o elemento incautado procede su lacrado y cadena de custodia, la confirmatoria judicial en caso de entrega voluntaria de bienes o documentos públicos, el procedimiento de incautación de documentos no privados, entre otros aspectos.
Ética profesional. Análisis desde el quehacer psicojurídico ecuatoriano
Authors: Francis Bone Monica Alexandra
Published: February 2025

En la actualidad, donde la palabra corrupción está ligada comúnmente a la falta de valores éticos y morales, así como al deseo desbordado del ser humano de tener por encima de ser, muchos abrigamos la esperanza del despertar, a la luz de la ética y la conciencia, pues sabemos que en medio de tanta violencia estructural algo no está bien en la sociedad. En este sentido, la labor profesional del psicólogo perito no está libre de ser corruptible, mucho más cuando se desconocen los sustentos teóricos que puedan respaldar u orientar el trabajo en el ámbito forense. Con este artículo aspiramos a generar autocrítica en el profesional psicólogo perito, de tal suerte que a la luz de los principios éticos se motive a generar un aprendizaje social significativo, a partir del descubrimiento de sus nudos críticos, con el compromiso de mejorarlos para lograr avanzar en ese aspecto y lograr intervenciones psicojurídicas que no respondan a sesgos o prejuicios personales sino a una perspectiva más objetiva, más técnica y obviamente ética.