bluuebunny/crossref_metadata_2025 huggingface dataset:
A comparative review of network meta‐analysis models in longitudinal randomized controlled trial
Authors: Tallarita Marta , De Iorio Maria , Baio Gianluca
Published: May 2019

Network meta‐analysis (NMA) technique extends the standard meta‐analysis methods, allowing pairwise comparison of all treatments in a network in the absence of head‐to‐head comparisons. Traditional NMA models consider a single endpoint for each trial. However, in many cases, trials in the network have different durations and/or report data at multiple time points. Moreover, these time points are often not the same for all trials. In this work, we review the most relevant methods that incorporate multiple time points and allow indirect comparisons of treatment effects across different longitudinal studies. In particular, we focus on the mixed treatment comparison developed by Dakin et al,[10] on the Bayesian evidence synthesis techniques—integrated two‐component prediction developed by Ding et al,[11] and on the more recent method based on fractional polynomials by Jansen et al.[12] We highlight the main features of each model and illustrate them in simulations and in a real data application. Our study shows that methods based on fractional polynomials offer a flexible modeling strategy in most applications.
Nonproportional hazards and unobserved heterogeneity in clustered survival data: When can we tell the difference?
Authors: Balan Theodor Adrian , Putter Hein
Published: May 2019

Multivariate survival data are frequently encountered in biomedical applications in the form of clustered failures (or recurrent events data). A popular way of analyzing such data is by using shared frailty models, which assume that the proportional hazards assumption holds conditional on an unobserved cluster‐specific random effect. Such models are often incorporated in more complicated joint models in survival analysis.

If the random effect distribution has finite expectation, then the conditional proportional hazards assumption does not carry over to the marginal models. It has been shown that, for univariate data, this makes it impossible to distinguish between the presence of unobserved heterogeneity (eg, due to missing covariates) and marginal nonproportional hazards. We show that time‐dependent covariate effects may falsely appear as evidence in favor of a frailty model also in the case of clustered failures or recurrent events data, when the cluster size or number of recurrent events is small. When true unobserved heterogeneity is present, the presence of nonproportional hazards leads to overestimating the frailty effect. We show that this phenomenon is somewhat mitigated as the cluster size grows.

We carry out a simulation study to assess the behavior of test statistics and estimators for frailty models in such contexts. The gamma, inverse Gaussian, and positive stable shared frailty models are contrasted using a novel software implementation for estimating semiparametric shared frailty models. Two main questions are addressed in the contexts of clustered failures and recurrent events: whether covariates with a time‐dependent effect may appear as indication of unobserved heterogeneity and whether the additional presence of unobserved heterogeneity can be detected in this case. Finally, the practical implications are illustrated in a real‐world data analysis example.
Investigating Treatment Effects of Participating Jointly in SNAP and WIC when the Treatment Is Validated Only for SNAP
Authors: Jensen Helen H. , Kreider Brent , Zhylyevskyy Oleksandr
Published: May 2019

The U.S. Department of Agriculture operates several food assistance programs aimed at alleviating food insecurity. We study whether participation in both participation in both SNAP and WIC alleviates food insecurity compared with participation in SNAP alone. We bound underlying causal effects by applying nonparametric treatment effect methods that allow for endogenous selection and underreported program participation when validation data are available for one program (treatment) but not the other. We estimate average treatment effects using data from the National Household Food Acquisition and Purchase Survey (FoodAPS). FoodAPS includes administrative data to validate SNAP participation. Information on local food prices allows us to construct a food expenditure‐based monotone instrumental variable that does not require a typical instrumental variable exclusion restriction. Under relatively weak monotonicity assumptions, we identify that the impact of participating in both programs relative to SNAP alone is strictly positive, suggesting that the programs are nonredundant. This evidence can support improved design and targeting of food programs.
An exploratory study on cooccurrence of design patterns and bad smells using software metrics
Authors: Sousa Bruno L. , Bigonha Mariza A. S. , Ferreira Kecia A. M.
Published: May 2019

A design pattern is a general reusable solution to commonly recurring problems in software projects. Bad smells are symptoms existing in the source code that possibly indicate the presence of a structural problem that requires code refactoring. Although design pattern and bad smells be different concepts, literature has shown that they may be related and cooccur during the evolution of a software system. This paper presents an empirical study that investigates cooccurrences of design patterns and bad smells as well as identifies the main factors that contribute to the emergence of the relationship between them. We carried out a case study with five Java systems to: (1) investigate if the use of design pattern reduces bad smell occurrence, (2) identify cooccurrences of design patterns and bad smells, and (3) identify situations that contribute for the cooccurrence emergence. As the main result, we found that the application of design pattern not necessarily avoid bad smell occurrences. The results also show that some design patterns such as composite, factory method, and singleton, are intrinsically modular and might be useful in creating high‐quality systems. However, other design patterns such as adapter‐command, proxy, and state‐strategy, have presented high cooccurrence frequency with bad smells; therefore, they require attention in their implementation. Finally, via manual inspection in the components with cooccurrence, we found that the identified cooccurrences appeared due to poor planning and inadequate application of design patterns.
Strength development and acid resistance of geopolymer based on waste clay brick powder and phosphorous slag
Authors: Vafaei Mostafa , Allahverdi Ali
Published: May 2019

This study aims to investigate the strength development and durability of geopolymer mortars based on waste clay brick powder (WCBP) and phosphorus slag exposed to acid attack. WCBP was partially replaced with slag (8, 16, and 24 wt%) and resulting blends were activated by an aqueous solution of NaOH and sodium silicate with different SiO2/Na2O ratios (MS) and Na2O concentrations. The optimized geopolymer mortar specimens were also immersed in sulfuric and hydrochloric acid solutions of pH = 1 for 6 months to assess changes in their physical and structural properties. The results were compared with those of Portland cement and high alumina cement mortars as control specimens. The key durability parameters measured were the evaluation of mass change, compressive strength loss, and deteriorated depth. Complementary studies were also carried out using X‐ray diffractometry, Fourier transform infrared spectroscopy, and scanning electron microscopy in line with energy dispersive X‐ray techniques to quantify the compositional and microstructural changes. The results demonstrate a potential of value‐added reuse application for WCBP by adding a suitable amount of slag. The findings also showed that geopolymer mortars were less susceptible to acid attack than the control mortars; however, superior enhancement in durability properties was not achieved.
Investigation on properties of coarse reclaimed aggregates and their effects on concrete strength and workability
Authors: Ly Boi T. , Far Harry
Published: May 2019

Fresh concrete waste is constantly generated in concrete batch plants during the production of ready‐mix concrete, and this waste is generally dumped in landfills. Natural aggregates are a finite resource and therefore there is a need to recycle this fresh concrete waste. An on‐site reclaimer can recycle fresh concrete waste to produce reclaimed aggregate (RA) and eliminate the need to dump fresh concrete waste in landfills. This study investigates the properties of coarse RAs sampled from an Australian concrete batch plant. It was observed that the particle size distribution was highly varied, while particle density and water absorption were similar to their parent aggregate. It was also found that concrete containing coarse RAs exhibited a higher workability and lower compressive strength than concrete containing natural coarse aggregates. Utilization of coarse RAs in concrete application is a viable option; however, more research will need to be conducted in this area.
Tracer test analysis using flow and transport simulation code and new analytical transport model 27 April 2019
Authors: Mitrinović David , Kovačević Srđan , Vojt Predrag , Pušić Milenko , Dimkić Milan
Published: May 2019

A convergent flow field tracer test, in two phases, with injection of sodium chloride solution, was conducted on a pumping well and neighboring piezometers belonging to the Kovin–Dubovac area drainage system, on the Serbian sector of the Danube River. The initial goal was to determine the values of hydrogeological parameters in order to analyze the results of the subsequent experiments involving injection of the selected solutes. SEAWAT code (through the Visual Modflow™ 2011 interface), as well as the newly developed analytical model for multilayer setting (1D transport solution for tracer injected as a Dirac impulse in a radial convergent flow field), was used to develop and calibrate a model of the studied portion of the aquifer. The new analytical model demonstrated a very good match to the measured values and to the results of numerical simulation, which indicates that it can be of great utility in characterizing transport conditions.

Practitioner points

Results confirm the conclusions of research papers on tracer tests that 10‐m scale tests regularly point to heterogeneous aquifer.

New analytical 1D radial transport model for multilayer setting demonstrated a very good match with numerical simulation and experimental data.

Developed analytical model is usable for characterizing transport conditions in a radial convergent multilayer flow field or other settings.
Boundary element analysis of 3D shell‐like rigid electrically conducting inclusions in anisotropic thermomagnetoelectroelastic solids
Authors: Pasternak Iaroslav , Sulym Heorhiy , Ilchuk Nataliia
Published: May 2019

The paper presents general boundary element approach for analysis of thermomagnetoelectroelastic solids containing shell‐like electrically conducting inclusions with high magnetic permittivity. The latter are modeled with opened surfaces with certain boundary conditions on their faces. Rigid displacement and rotation, along with constant electric and magnetic potentials of inclusions are accounted for in these boundary conditions. Formulated boundary value problem is reduced to a system of singular boundary integral equations, which is solved numerically by the boundary element method. Special attention is paid to the field singularity at the front line of a shell‐like inclusion. Special shape functions are introduced, which account for this square‐root singularity and allow accurate determination of field intensity factors. Approaches for fast and accurate numerical evaluation of anisotropic thermomagnetoelectroelastic kernels are discussed, which are crucial in derivation of fast and precise boundary element approach. Numerical examples are presented.
Strong- vs. weak-coupling pictures of jet quenching: a dry run using QED
Authors: Arnold Peter , Iqbal Shahin , Rase Tanner
Published: May 2019

Abstract

High-energy partons (E ≫ T ) traveling through a quark-gluon plasma lose energy by splitting via bremsstrahlung and pair production. Regardless of whether or not the quark-gluon plasma itself is strongly coupled, an important question lying at the heart of philosophically different approaches to energy loss is whether the high-energy partons of an in-medium shower can be thought of as a collection of individual particles, or whether their coupling to each other is also so strong that a description as high-energy “particles” is inappropriate. We discuss some possible theorists’ tests of this question for simple situations (e.g. an infinite, non-expanding plasma) using thought experiments and first-principles quantum field theory calculations (with some simplifying approximations). The physics of in-medium showers is substantially affected by the Landau-Pomeranchuk-Midgal (LPM) effect, and our proposed tests require use of what might be called “next-to-leading order” LPM results, which account for quantum interference between consecutive splittings. The complete set of such results is not yet available for QCD but is already available for the theory of large-N
f QED. We therefore use large-N
f QED as an example, presenting numerical results as a function of N
f
α, where α is the strength of the coupling at the relevant high-energy scale characterizing splittings of the high-energy particles.
Representing seesaw neutrino models and their motion in lepton flavour space
Authors: Di Bari Pasquale , Re Fiorentin Michele , Samanta Rome
Published: May 2019

Abstract

We discuss how seesaw neutrino models can be graphically represented in lepton flavour space. We examine various popular models and show how this representation helps understanding their properties and connection with experimental data showing in particular how certain texture zero models are ruled out. We also introduce a new matrix, the bridging matrix, that brings from the light to the heavy neutrino mass flavour basis, showing how this is related to the orthogonal matrix and how different quantities are easily expressed through it. We then show how one can randomly generate orthogonal and leptonic mixing matrices uniformly covering all flavour space in an unbiased way (Haar-distributed matrices). Using the isomorphism between the group of complex rotations and the Lorentz group, we also introduce the concept of Lorentz boost in flavour space for a seesaw model and how this has an insightful physical interpretation. Finally, as a significant application, we consider N
2-leptogenesis. Using current experimental values of low energy neutrino parameters, we show that the probability that at least one flavoured decay parameter of the lightest right-handed neutrino is smaller than unity is about 49% (to be compared with the tiny probability that the total decay parameter is smaller than unity, P (K
I
< 1) ∼ 0.1%, confirming the crucial role played by flavour effects). On the other hand when m
1 ≳ 0.1 eV this probability reduces to less than 5%, showing how also N
2-leptogenesis disfavours degenerate light neutrinos.
Distraction by deviant sounds: disgusting and neutral words capture attention to the same extent
Authors: Parmentier Fabrice B. R. , Fraga Isabel , Leiva Alicia , Ferré Pilar
Published: May 2019

Several studies have argued that words evoking negative emotions, such as disgust, grab attention more than neutral words, and leave traces in memory that are more persistent. However, these conclusions are typically based on tasks requiring participants to process the semantic content of these words in a voluntarily manner. We sought to compare the involuntary attention grabbing power of disgusting and neutral words using them as rare and unexpected auditory distractors in a cross-modal oddball task, and then probing the participants’ memory for these stimuli in a surprise recognition task. Frequentist and Bayesian analyses converged to show that, compared to a standard tone, disgusting and neutral auditory words produced significant but equivalent levels of distraction in a visual categorization task, that they elicited comparable levels of memory discriminability in the incidental recognition task, and that the participants’ individual sensitivity to disgust did not influence the results. Our results suggest that distraction by unexpected words is not modulated by their emotional valence, at least when these words are task-irrelevant and are temporally and perceptually decoupled from the target stimuli.
Predicting mental health improvement and deterioration in a large community sample of 11- to 13-year-olds
Authors: Wolpert Miranda , Zamperoni Victoria , Napoleone Elisa , Patalay Praveetha , Jacob Jenna , Fokkema Marjolein , Promberger Marianne , Costa da Silva Luís , Patel Meera , Edbrooke-Childs Julian
Published: May 2019

Of children with mental health problems who access specialist help, 50% show reliable improvement on self-report measures at case closure and 10% reliable deterioration. To contextualise these figures it is necessary to consider rates of improvement for those in the general population. This study examined rates of reliable improvement/deterioration for children in a school sample over time. N = 9074 children (mean age 12; 52% female; 79% white) from 118 secondary schools across England provided self-report mental health (SDQ), quality of life and demographic data (age, ethnicity and free school meals (FSM) at baseline and 1 year and self-report data on access to mental health support at 1 year). Multinomial logistic regressions and classification trees were used to analyse the data. Of 2270 (25%) scoring above threshold for mental health problems at outset, 27% reliably improved and 9% reliably deteriorated at 1-year follow up. Of 6804 (75%) scoring below threshold, 4% reliably improved and 12% reliably deteriorated. Greater emotional difficulties at outset were associated with greater rates of reliable improvement for both groups (above threshold group: OR = 1.89, p < 0.001, 95% CI [1.64, 2.17], below threshold group: OR = 2.23, p < 0.001, 95% CI [1.93, 2.57]). For those above threshold, higher baseline quality of life was associated with greater likelihood of reliable improvement (OR = 1.28, p < 0.001, 95% CI [1.13, 1.46]), whilst being in receipt of FSM was associated with reduced likelihood of reliable improvement (OR = 0.68, p < 0.01, 95% CI [0.53, 0.88]). For the group below threshold, being female was associated with increased likelihood of reliable deterioration (OR = 1.20, p < 0.025, 95% CI [1.00, 1.42]), whereas being from a non-white ethnic background was associated with decreased likelihood of reliable deterioration (OR = 0.66, p < 0.001, 95% CI [0.54, 0.80]). For those above threshold, almost one in three children showed reliable improvement at 1 year. The extent of emotional difficulties at outset showed the highest associations with rates of reliable improvement.
App Adoption: The Effect on Purchasing of Customers who have Used a Mobile Website Previously
Authors: Liu Huan , Lobschat Lara , Verhoef Peter C. , Zhao Hong
Published: May 2019

A key question for retailers who already offer a mobile website is, whether they should add an app as an additional purchase channel. We address this issue by exploring whether consumers’ app adoption stimulates additional purchases and how this change in purchase behavior differs across customers with different levels of spending share for different product categories and customer loyalty. By using transactional data from a Chinese online retailer, we show that app adopters have higher purchase incidence, buy more frequently, and spend more in each order than non-adopters. We also find that app adoption has a stronger positive effect on the order size of customers who have a lower spending share of high-price products and customers who are less loyal to the focal retailer. Hereby, we contribute to multichannel and mobile marketing literature by empirically examining the effects of adding a similar (mobile) purchase channel to an already established (mobile) purchase channel. Managerially, our results suggest that apps are worth investing in despite their similarity to mobile websites and can induce non-loyal customers to purchase more and thus potentially foster these customers’ loyalty.
Loss of floating glacier tongues from the Yelverton Bay region, Ellesmere Island, Canada
Authors: WHITE ADRIENNE , COPLAND LUKE
Published: May 2019

A total of eight floating glacier tongues have shrunk in area by >85% from the Yelverton Bay region of Northern Ellesmere Island since 1959, with unusually large losses since 2005. To better understand the causes of these losses, this study undertakes the first examination of ice tongue changes in this region, including an assessment of changes in surrounding marine ice (i.e. sea ice, sikussak and mélange), and atmospheric and oceanographic forcings. From 1959 to 2017, the total ice tongue area decreased by 49.07 km2, with the majority of this loss occurring from 2005 to 2009 (34.68 km2). The loss of ice tongues since 2005 occurred when open water replaced multi-year landfast sea ice (MLSI) and first-year sea ice in the regions adjacent to the ice tongues. These changes were accompanied by an increase in mean annual mid-depth (i.e. 100 and 200 m) ocean temperatures from −0.29°C from 1999 to 2005 to 0.67°C from 2006 to 2012. Despite the recent return of ocean temperatures to below pre-2006 levels, atmospheric summer temperatures have continued to rise (+0.15°C decade−1 between 1948 and 2016), with open water continuing to occur. Without the sustained presence of MLSI in this region the ice tongues are unable to stabilize, making it unlikely that they will re-form in the current climate.
PROJECTIVE CLONE HOMOMORPHISMS
Authors: BODIRSKY MANUEL , PINSKER MICHAEL , PONGRÁCZ ANDRÁS
Published: May 2019

It is known that a countable

$\omega $
-categorical structure interprets all finite structures primitively positively if and only if its polymorphism clone maps to the clone of projections on a two-element set via a continuous clone homomorphism. We investigate the relationship between the existence of a clone homomorphism to the projection clone, and the existence of such a homomorphism which is continuous and thus meets the above criterion.
Policy over party: comparing the effects of candidate ideology and party on affective polarization
Authors: Lelkes Yphtach
Published: May 2019

At least two theories have been offered that explain the rise of affective polarization. Some scholars, relying on social identity theory, argue that as the relevance of party identification increased, Americans became more likely to see their in-party in positive terms and the out-party in negative terms. Other scholars argue that affective polarization is a reaction to increasingly extreme political actors. This study seeks to arbitrate between these two theories of affective polarization through a survey experiment which asks respondents to rate candidates whose party (or lack thereof) and ideology (or lack thereof) is randomly assigned. In line with the policy-oriented view of affective polarization, respondents reacted far more strongly to ideology than party, especially if it was the ideology of the member of the out-party.
Just Who Do Canadian Journalists Think They Are? Political Role Conceptions in Global and Historical Perspective
Authors: Rollwagen Heather , Shapiro Ivor , Bonin-Labelle Geneviève , Fitzgerald Lindsay , Tremblay Lauriane
Published: May 2019

In view of the robust link often inferred between autonomous journalism and the strength of a society's democratic institutions, and against the background of current challenges to journalists’ traditional roles as purveyors of timely and independent information, we interviewed 352 Canadian journalists about their social and political roles and the influences on their news choices. Comparison of their responses against an international data set (N= 27,567) suggests that Canadian journalists place greater value on detached monitorial roles and claim relatively greater autonomy from commercial and other influences on their work. Further, in comparing these findings to an influential panel study from 1996 to 2003, we conclude that the Canadian journalists’ “credo,” focused on neutral reporting and oriented more to perceived public interest than to business or audience interests, remains surprisingly intact despite contemporary pressures on news forms and business models. This professed neutrality is mitigated by a desire to promote diversity and tolerance.
The highly diverse gastropod assemblages associated with Sargassum spp. (Phaeophyceae: Fucales) habitats
Authors: Longo Pedro Augusto Dos Santos , Mansur Karine Ferreira Ribeiro , Leite Fosca Pedini Pereira , Passos Flávio Dias
Published: May 2019

Macrophytes provide a habitat for many species of marine invertebrates, the gastropods being one of the main components. This study provides new information aboutSargassum-associated gastropod biodiversity, through characterization of the fauna from a highly impacted area of Brazil, investigating its variation at a small spatial scale and between two main seasons of the year, as well as its relationship with macroalgae parameters. Density of gastropods was higher during the warmest season and varied throughout sampling sites. A significant and positive, however weak, relationship between gastropod density andSargassumdry weight was found in all localities. For all sites, a marked and unusual dominance ofBittiolum variumwas observed. The high dominance of this species seems to be related to the impacts caused by shipping activities and highway construction in the 1970s and 1980s, which caused a decline in local species diversity that seems to have continued until now. Many species, both typical of these habitats and characteristic of other, nearby habitats, benefit fromSargassumsp. These macrophytes allow gastropods to establish and grow during their most vulnerable stages, as shown by the growth series and juvenile forms found for most species of gastropods. The present data highlight the importance of macrophyte habitats for gastropod biodiversity in coastal areas and call attention to the importance of raising knowledge on this fauna, especially in impacted areas, thus contributing to the conservation of these highly diverse and ecologically important macrophyte–gastropod systems.
Comparisons of N-glycans across invertebrate phyla
Authors: Paschinger Katharina , Wilson Iain B. H.
Published: May 2019

Many invertebrates are either parasites themselves or vectors involved in parasite transmission; thereby, the interactions of parasites with final or intermediate hosts are often mediated by glycans. Therefore, it is of interest to compare the glycan structures or motifs present across invertebrate species. While a typical vertebrate modification such as sialic acid is rare in lower animals, antennal and core modifications of N-glycans are highly varied and range from core fucose, galactosylated fucose, fucosylated galactose, methyl groups, glucuronic acid and sulphate through to addition of zwitterionic moieties (phosphorylcholine, phosphoethanolamine and aminoethylphosphonate). Only in some cases are the enzymatic bases and the biological function of these modifications known. We are indeed still in the phase of discovering invertebrate glycomes primarily using mass spectrometry, but molecular biology and microarraying techniques are complementary to the determination of novel glycan structures and their functions.
Evaluation of the multispecies coalescent method to explore intra-Trypanosoma cruzi I relationships and genetic diversity
Authors: Gómez-Hernández César , Pérez Sergio D. , Rezende-Oliveira Karine , Barbosa Cecilia G. , Lages-Silva Eliane , Ramírez Luis Eduardo , Ramírez Juan David
Published: May 2019

Chagas Disease is a zoonosis caused by the parasite Trypanosoma cruzi. Several high-resolution markers have subdivided T. cruzi taxon into at least seven lineages or Discrete Typing Units (DTUs) (TcI-TcVI and TcBat). Trypanosoma cruzi I is the most diverse and geographically widespread DTU. Recently a TcI genotype related to domestic cycles was proposed and named as TcIDOM. Herein, we combined traditional markers and housekeeping genes and applied a Multispecies Coalescent method to explore intra-TcI relationships, lineage boundaries and genetic diversity in a random set of isolates and DNA sequences retrieved from Genbank from different countries in the Americas. We found further evidence supporting TcIDOM as an independent and emerging genotype of TcI at least in Colombia and Venezuela. We also found evidence of high phylogenetic incongruence between parasite's gene trees (including introgression) and embedded species trees, and a lack of genetic structure among geography and hosts, illustrating the complex dynamics and epidemiology of TcI across the Americas. These findings provide novel insights into T. cruzi systematics and epidemiology and support the need to assess parasite diversity and lineage boundaries through hypothesis testing using different approaches to those traditionally employed, including the Bayesian Multispecies coalescent method.
Ageing in a changing place: a qualitative study of neighbourhood exclusion
Authors: Dahlberg Lena
Published: May 2019

An inclusive neighbourhood is a key facilitator enabling older adults to age in place. Neighbourhoods have been identified as a dimension of social exclusion important to older adults, and it has been argued that older adults are particularly vulnerable to neighbourhood change. The aim of this study was to explore older adults’ experiences of neighbourhood exclusion within the context of neighbourhood change. Focus groups were undertaken in the urban and rural areas of a metropolitan borough in England involving a total of 41 older adults, with data analysed via thematic analysis. Urban areas in the borough studied have transformed following the closure of the mining industry, with a high level of deprivation in many areas, while some rural areas have undergone gentrification. Within the context of structural neighbourhood change, four themes were identified: community cohesion, political agency, feelings of safety and the physical environment. The themes were interlinked, which calls for collaboration across traditional lines of professional responsibility, and for research that encompasses different aspects of neighbourhood exclusion. This study contributes with knowledge on older adults’ experiences of exclusion, including novel findings on the importance of political agency and collective memory, and identifies actions to combat exclusion. An active involvement of older adults in the development of initiatives to tackle social exclusion is recommended.
Combined XRD-XRF cluster analysis for automatic chemical and crystallographic surface mappings
Authors: Bortolotti M. , Lutterotti L. , Borovin E. , Martorelli D.
Published: May 2019

X-ray diffraction-X-ray fluorescence (XRD-XRF) data sets obtained from surface scans of synthetic samples have been analysed by means of different data clustering algorithms, with the aim to propose a methodology for automatic crystallographic and chemical classification of surfaces. Three data clustering strategies have been evaluated, namely hierarchical, k-means, and density-based clustering; all of them have been applied to the distance matrix calculated from the single XRD and XRF data sets as well as the combined distance matrix. Classification performance is reported for each strategy both in numerical form as the corrected Rand index and as a visual reconstruction of the surface maps. Hierarchical and k-means clustering offered comparable results, depending on both sample complexity and data quality. When applied to XRF data collected on a two-phases test sample, both algorithms allowed to obtain Rand index values above 0.8, whereas XRD data collected on the same sample gave values around 0.5; application to the combined distance matrix improved the correlation to about 0.9. In the case of a more complex multi-phase sample, it has also been found that classification performance strongly depends on both data quality and signal contrast between different regions; again, the adoption of the combined dissimilarity matrix offered improved classification performance.
Emotion dysregulation, temperamental vulnerability, and parental depression in adolescents: Correspondence between physiological and informant-report measures
Authors: Van Beveren Marie-Lotte , Mueller Sven C. , Braet Caroline
Published: May 2019

Although numerous studies reveal altered respiratory sinus arrhythmia (RSA) among children, adolescents, and adults who exhibit emotion dysregulation, effects of temperamental vulnerability and parental mental health on RSA remain unclear. We evaluated the relationship among emotion regulation, RSA, and RSA reactivity in a pooled sample of 24 vulnerable and 31 resilient adolescents (mean age = 13.69 years; 60% girls), including associations with temperamental vulnerability and parental depressive symptoms. Participants watched a neutral film clip while their resting RSA was recorded, and then completed a reward and frustration task, using an affective Posner paradigm. Temperament and emotion regulation were assessed via self-report and parent report, and parents reported on their own depressive symptoms. Low resting RSA was associated with temperamental negative emotionality, whereas greater RSA reactivity to frustration was associated with maladaptive emotion regulation strategies. No significant relations were found between RSA and parental depressive symptoms. This study elucidates the role of RSA as a biomarker of individual differences in emotion dysregulation and temperamental vulnerability and stresses the importance of considering multiple units of analyses, as well as functional domains, when studying emotional responding and regulation in adolescents.
Systematic derivation of a surface polarisation model for planar perovskite solar cells – CORRIGENDUM
Authors: COURTIER N. E. , FOSTER J. M. , O’KANE S. E. J. , WALKER A. B. , RICHARDSON G.
Published: May 2019

Following publication, errors were discovered in the y-axis labels of the electron and hole concentration plots in the following figure panels: figure 4c, figure 4d, figure 5c, figure 5d, figure 6c, figure 6d, figure 8c and figure 8d. The error does not affect the description, analysis or conclusions. The correct representation of the figure panels are shown here.
Safety of enteral sildenafil in hemodynamically unstable children
Authors: Bednarz Alexandra M. , Israel Emily N. , Beckman Elizabeth J. , Johansen Michael , Thomas Christopher A.
Published: May 2019

Background:

Enteral sildenafil may be used in the intensive care unit for treatment of pulmonary arterial hypertension. We aimed to determine if initial enteral sildenafil dosing is safe in children receiving concurrent vasoactive infusions.

Methods:

We performed a single-centre retrospective chart review that included patients less than 2 years of age in paediatric and cardiovascular intensive care units at an academic medical centre from 1 January, 2010 to 30 November, 2016. Included patients received concomitant enteral sildenafil and a continuously infused vasoactive agent. Exclusion criteria consisted of mechanical circulatory support, any form of dialysis, or a suspicion of septic shock at the time of sildenafil initiation. We sought to identify patients who developed worsening hemodynamic instability after initiation of enteral sildenafil defined as one or more of the following observations within 24 hours of sildenafil initiation: sildenafil discontinuation, total fluid bolus receipt >10 ml/kg, increased vasoactive support, epinephrine intravenous push administration, and/or the initiation of mechanical circulatory support.

Results:

Worsening hemodynamic instability was identified in 35% of the 130-patient cohort. Patients younger than 4 months were at increased risk of further hemodynamic instability compared with older patients (56% versus 44%, p = 0.0003) despite receiving lower median doses (1.28 mg/kg/day versus 1.78 mg/kg/day, p = 0.01).

Conclusions:

Critically ill children receiving vasoactive infusions may be at increased risk for further hemodynamic instability after initiation of enteral sildenafil, particularly in younger patients. This population may benefit from lower starting enteral sildenafil doses of 0.25 mg/kg/dose or less every 8 hours to avoid further hemodynamic compromise.
Threat Perception and Public Preparedness for Earthquakes in Italy
Authors: Bodas Moran , Giuliani Fabiana , Ripoll-Gallardo Alba , Caviglia Marta , Dell’Aringa Marcelo Farah , Linty Monica , Della Corte Francesco , Ragazzoni Luca
Published: May 2019

Introduction:

Italy is prone to major earthquakes and has experienced several devastating earthquakes in the far and recent past. The objectives of this study were to assess the level of Italian households’ preparedness for earthquakes and to measure the public’s perception of the risk and its impact on preparedness behavior.

Hypothesis:

Italian households’ preparedness for earthquakes is insufficient and is influenced by different threat perception components that were assessed.

Methods:

A cross-sectional study, using an online questionnaire, was conducted in early 2018. The sample included 1,093 responders from a diverse sociodemographic background. The primary outcome was the Preparedness Index (PI), a score indicating the number of preparedness actions complied-with out of 10.

Results:

The PI’s mean was 5.26 (SD = 2.17). The recommendation most complied-with was keeping a flashlight at home (87.7%) and the least was securing the kitchen cupboards (15.1%). The PI was positively correlated with a higher sense of preparedness (r = 0.426; P <.001). The PI was higher for responders residing in high-seismic-risk areas and those who experienced a major earthquake before. The predictors of PI were: gender, age, prior experience, sense of preparedness, searching for information, and threat intrusiveness (negatively).

Conclusions:

The findings demonstrate a medium-level of preparedness; however, this might be circumstantial. Italians perceive major earthquakes to be unlikely, yet severe if and when they do occur. A validated tool in Italian now exists and can be used in future studies.

Bodas M, Giuliani F, Ripoll-Gallardo A, Caviglia M, Dell’Aringa MF, Linty M, Della Corte F, Ragazzoni L. Threat perception and public preparedness for earthquakes in Italy.Prehosp Disaster Med. 2019;34(2):114–124
Health Risks in Disaster Responders: A Conceptual Framework
Authors: Khatri Jyoti , Fitzgerald Gerard , Poudyal Chhetri Meen B.
Published: May 2019

Introduction:

Disasters cause severe disruption to socio-economic, infrastructural, and environmental aspects of community and nation. While the impact of disasters is strongly felt by those directly affected, they also have significant impacts on the mental and physical health of relief/recovery workers and volunteers. Variations in the nature and scale of disasters necessitate different approaches to risk management and hazard reduction during the response and recovery phases.

Method:

Published articles (2010-2017) on the quantitative and quantitative relationship between disasters and the physical and mental health of relief/recovery workers and volunteers were systematically collected and reviewed. A total of 162 relevant studies were identified. Physical injuries and mental health impacts were categorized into immediate, short-term, and chronic conditions. A systematic review of the literature was undertaken to explore the health risks and injuries encountered by disaster relief workers and volunteers, and to identify the factors contributing to these and relating mitigation strategies.

Results:

There were relatively few studies into this issue. However, the majority of the scrutinized articles highlighted the dependence of nature and scope of injuries with the disaster type and the types of responders, while the living and working environment and socio-economic standing also had significant influence on health outcomes.

Conclusion:

A conceptual framework derived from the literature review clearly illustrated several critical elements that directly or indirectly cause damage to physical and mental health of disaster responders. Pre-disaster and post-disaster risk mitigation approaches may be employed to reduce the vulnerability of both volunteers and workers while understanding the identified stressors and their relationships.

Khatri KC J, Fitzgerald G, Poudyal Chhetri MB. Health risks in disaster responders: a conceptual framework. Prehosp Disaster Med. 2019;34(2):209–216
Evaluation of Oklahoma’s Electronic Death Registration System and Event Fatality Markers for Disaster-Related Mortality Surveillance – Oklahoma USA, May 2013
Authors: Issa Anindita N. , Baker Kelly , Pate Derek , Law Royal , Bayleyegn Tesfaye , Noe Rebecca S.
Published: May 2019

Introduction:

Official counts of deaths attributed to disasters are often under-reported, thus adversely affecting public health messaging designed to prevent further mortality. During the Oklahoma (USA) May 2013 tornadoes, Oklahoma State Health Department Division of Vital Records (VR; Oklahoma City, Oklahoma USA) piloted a flagging procedure to track tornado-attributed deaths within its Electronic Death Registration System (EDRS). To determine if the EDRS was capturing all tornado-attributed deaths, the Centers for Disease Control and Prevention (CDC; Atlanta, Georgia USA) evaluated three event fatality markers (EFM), which are used to collate information about deaths for immediate response and retrospective research efforts.

Methods:

Oklahoma identified 48 tornado-attributed deaths through a retrospective review of hospital morbidity and mortality records. The Centers for Disease Control and Prevention (CDC; Atlanta, Georgia USA) analyzed the sensitivity, timeliness, and validity for three EFMs, which included: (1) a tornado-specific flag on the death record; (2) a tornado-related term in the death certificate; and (3) X37, the International Classification of Diseases, 10th Revision (ICD-10) code in the death record for Victim of a Cataclysmic Storm, which includes tornadoes.

Results:

The flag was the most sensitive EFM (89.6%; 43/48), followed by the tornado term (75.0%; 36/48), and the X37 code (56.2%; 27/48). The most-timely EFM was the flag, which took 2.0 median days to report (range 0-10 days), followed by the tornado term (median 3.5 days; range 1-21), and the X37 code (median >10 days; range 2-122). Over one-half (52.1%; 25/48) of the tornado-attributed deaths were missing at least one EFM. Twenty-six percent (11/43) of flagged records had no tornado term, and 44.1% (19/43) had no X37 code. Eleven percent (4/36) of records with a tornado term did not have a flag.

Conclusion:

The tornado-specific flag was the most sensitive and timely EFM. Using the flag to collate death records and identify additional deaths without the tornado term and X37 code may improve immediate response and retrospective investigations. Moreover, each of the EFMs can serve as quality controls for the others to maximize capture of all disaster-attributed deaths from vital statistics records in the EDRS.

Issa AN, Baker K, Pate D, Law R, Bayleyegn T, Noe RS. Evaluation of Oklahoma’s Electronic Death Registration System and event fatality markers for disaster-related mortality surveillance – Oklahoma USA, May 2013. Prehosp Disaster Med. 2019;34(2):125–131
The Hennepin Ketamine Study Investigators’ Reply
Authors: Ho Jeffrey D. , Cole Jon B. , Klein Lauren R. , Olives Travis D. , Driver Brian E. , Moore Johanna C. , Nystrom Paul C. , Arens Annie M. , Simpson Nicholas S. , Hick John L. , Chavez Ross A. , Lynch Wendy L. , Miner James R.
Published: May 2019

We read with interest the recent editorial, “The Hennepin Ketamine Study,” by Dr. Samuel Stratton commenting on the research ethics, methodology, and the current public controversy surrounding this study.1 As researchers and investigators of this study, we strongly agree that prospective clinical research in the prehospital environment is necessary to advance the science of Emergency Medical Services (EMS) and emergency medicine. We also agree that accomplishing this is challenging as the prehospital environment often encounters patient populations who cannot provide meaningful informed consent due to their emergent conditions. To ensure that fellow emergency medicine researchers understand the facts of our work so they may plan future studies, and to address some of the questions and concerns in Dr. Stratton’s editorial, the lay press, and in social media,2 we would like to call attention to some inaccuracies in Dr. Stratton’s editorial, and to the lay media stories on which it appears to be based.

Ho JD, Cole JB, Klein LR, Olives TD, Driver BE, Moore JC, Nystrom PC, Arens AM, Simpson NS, Hick JL, Chavez RA, Lynch WL, Miner JR. The Hennepin Ketamine Study investigators’ reply. Prehosp Disaster Med. 2019;34(2):111–113
Data-Based Teaching: An Introduction and Call for Collaboration
Authors: Loepp Eric
Published: May 2019

Political science instructors increasingly use interactive pedagogies that emphasize active learning over traditional lecture formats. I contribute to this effort by developing a data-based teaching method that relies on student-generated data to illustrate course concepts and to serve as a foundation for a variety of activities in political science classrooms. This article summarizes the technique based on my experience in an introductory course in American government. However, given that this method is not intrinsically limited to any topic or area, I also provide examples of how the basic framework may be applied to other subfields in political science. I conclude by calling for the creation of a network of teacher–scholars interested in developing, sharing, and refining best practices related to data-based teaching.