bluuebunny/crossref_metadata_2025 huggingface dataset:
Research on Rolling Bearing Fault Diagnosis Based on Volterra Kernel Identification and KPCA
Authors: Wang Yahui , Dong Rong , Wang Xinchao , Zhang Xunying
Published: August 2023

A rolling bearing fault diagnosis method based on the Volterra series and kernel principal component analysis (KPCA) is proposed. In the proposed method, first, the improved genetic algorithm (IGA) is used to identify the Volterra series model of the bearing in four states: normal, rolling element fault, inner ring fault, and outer ring fault. The Volterra time-domain kernel is used as the feature vector for kernel principal component analysis to classify and identify the faults. The feasibility of the fault diagnosis method of the Volterra level and kernel principal component analysis is verified by the experimental results.
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity
Authors: Yang Moon Hee , Tran Timothy H. , Hunt Bethany , Agnor Rebecca , Johnson Christian W. , Shui Bing , Waybright Timothy J. , Nowak Jonathan A. , Stephen Andrew G. , Simanshu Dhirendra K. , Haigis Kevin M.
Published: August 2023

RAS proteins are GTPases that regulate a wide range of cellular processes. RAS activity is dependent on its nucleotide-binding status, which is modulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). KRAS can be acetylated at lysine 104 (K104), and an acetylation-mimetic mutation of K104 to glutamine (K104Q) attenuates the in vitro–transforming capacity of oncogenic KRAS by interrupting GEF-induced nucleotide exchange. To assess the effect of this mutation in vivo, we used CRISPR-Cas9 to generate mouse models carrying the K104Q point mutation in wild-type and conditional KrasLSL-G12D alleles. Homozygous animals for K104Q were viable, fertile, and arose at the expected Mendelian frequency, indicating that K104Q is not a complete loss-of-function mutation. Consistent with our previous findings from in vitro studies, however, the oncogenic activity of KRASG12D was significantly attenuated by mutation at K104. Biochemical and structural analysis indicated that the G12D and K104Q mutations cooperate to suppress GEF-mediated nucleotide exchange, explaining the preferential effect of K104Q on oncogenic KRAS. Furthermore, K104 functioned in an allosteric network with M72, R73, and G75 on the α2 helix of the switch-II region. Intriguingly, point mutation of glycine 75 to alanine (G75A) also showed a strong negative regulatory effect on KRASG12D. These data demonstrate that lysine at position 104 is critical for the full oncogenic activity of mutant KRAS and suggest that modulating the sites in its allosteric network may provide a unique therapeutic approach in cancers expressing mutant KRAS.

Significance:

An allosteric network formed by interaction between lysine 104 and residues in the switch-II domain is required for KRAS oncogenicity, which could be exploited for developing inhibitors of the activated oncoprotein.
Supplementary Table 2 from Association between Outdoor Light at Night and Prostate Cancer in the Health Professionals Follow-up Study
Authors: Chowdhury-Paulino Ilkania M. , Hart Jaime E. , James Peter , Iyer Hari S. , Wilt Grete E. , Booker Benjamin D. , Nethery Rachel C. , Laden Francine , Mucci Lorelei A. , Markt Sarah C.
Published: August 2023

Supplementary Table 2. Hazard ratios and 95% confidence intervals for the association between outdoor light at night (LAN) and lethal prostate cancer incidence in HPFS 1986-2016, stratified by urbanicity (urban: >1,000 people/mi2, nonurban: <1,000 people/mi2), PSA screening intensity, and neighborhood socioeconomic status
Supplementary Table S4 from Racial and Ethnic Variation in Diagnostic Mammography Performance among Women Reporting a Breast Lump
Authors: Nyante Sarah J. , Abraham Linn , Aiello Bowles Erin J. , Lee Christoph I. , Kerlikowske Karla , Miglioretti Diana L. , Sprague Brian L. , Henderson Louise M.
Published: August 2023

Model-based comparisons of diagnostic mammography performance by race and ethnicity
Supplementary Table S3 from Racial and Ethnic Variation in Diagnostic Mammography Performance among Women Reporting a Breast Lump
Authors: Nyante Sarah J. , Abraham Linn , Aiello Bowles Erin J. , Lee Christoph I. , Kerlikowske Karla , Miglioretti Diana L. , Sprague Brian L. , Henderson Louise M.
Published: August 2023

Tabulation of the types of false-negative cancers diagnosed
Supplemental Table 5 from Germline Mutations in 12 Genes and Risk of Ovarian Cancer in Three Population-Based Cohorts
Authors: Kotsopoulos Joanne , Hathaway Cassandra A. , Narod Steven A. , Teras Lauren R. , Patel Alpa V. , Hu Chunling , Yadav Siddhartha , Couch Fergus J. , Tworoger Shelley S.
Published: August 2023

Supplemental Table 5: Mutation frequencies in ovarian cancer cases and controls in the NHS, NHSII, and CPSII cohorts separately
Table S7 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

QPCR primers
Table S5 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

Genes present in each of the 8 clusters
Table S3 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

Beta scores generated for DMSO and BYL719 treated populations using MAGeCK analysis pipeline
Table S2 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

Raw read counts for each guide RNA in screen
Figure S4 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

Figure S4 shows loss of BCL-XL and BYL719 treatment in additional gastric cancer cell line
Figure S1 from CBF-Beta Mitigates PI3K-Alpha–Specific Inhibitor Killing through PIM1 in PIK3CA-Mutant Gastric Cancer
Authors: Stanland Lyla J. , Ang Hazel X. , Hoj Jacob P. , Chu Yunqiang , Tan Patrick , Wood Kris C. , Luftig Micah A.
Published: August 2023

Figure S1 shows BYL719 and DMSO beta scores calculated by the MAGeCK analysis pipeline
Supplementary Video S18 from Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Supplementary Video S18 shows the clustering video of siECE1 transfected ST6WT cells presented in Supplementary Fig.S14B.
Supplementary Video S15 from Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Supplementary Video S15 shows the clustering video of scrRNA transfected ST6WT cells presented in Supplementary Fig.S14B.
Supplementary Video S13 from Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Supplementary Video S13 shows the clustering video of siPODXL transfected ST6KO cells presented in Fig.5E.
Supplementary Video S11 from Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Supplementary Video S11 shows the clustering video of siECE1 transfected ST6KO cells presented in Fig.5E.
Supplementary Video S1 from Dynamic Glycoprotein Hyposialylation Promotes Chemotherapy Evasion and Metastatic Seeding of Quiescent Circulating Tumor Cell Clusters in Breast Cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Supplementary Video S1 shows the clustering video of SNA high cells presented in Fig.2A.
Data from Dynamic glycoprotein hyposialylation promotes chemotherapy evasion and metastatic seeding of quiescent circulating tumor cell clusters in breast cancer
Authors: Dashzeveg Nurmaa K. , Jia Yuzhi , Zhang Youbin , Gerratana Lorenzo , Patel Priyam , Shajahan Asif , Dandar Tsogbadrakh , Ramos Erika K. , Almubarak Hannah F. , Adorno-Cruz Valery , Taftaf Rokana , Schuster Emma J. , Scholten David , Sokolowski Michael T. , Reduzzi Carolina , El-Shennawy Lamiaa , Hoffmann Andrew D. , Manai Maroua , Zhang Qiang , D'Amico Paolo , Azadi Parastoo , Colley Karen J. , Platanias Leonidas C. , Shah Ami N. , Gradishar William J. , Cristofanilli Massimo , Muller William A. , Cobb Brian A. , Liu Huiping
Published: August 2023

Abstract
Most of the circulating tumor cells (CTCs) are detected as single cells, whereas a small proportion of CTCs in multicellular clusters with stemness properties possess 20-100 times higher metastatic propensity than the singles. Here we report that CTC dynamics in both singles and clusters in response to therapies predict overall survival for breast cancer. Chemotherapy-evasive CTC clusters are relatively quiescent with a specific loss of ST6GAL1-catalyzed α2,6-sialylation in glycoproteins. Dynamic hyposialylation in CTCs or deficiency of ST6GAL1 promotes cluster formation for metastatic seeding and enables cellular quiescence to evade paclitaxel treatment in breast cancer. Glycoproteomic analysis reveals newly identified protein substrates of ST6GAL1, such as adhesion or stemness markers PODXL, ICAM1, ECE1, ALCAM1, CD97, and CD44, contributing to CTC clustering (aggregation) and metastatic seeding. As proof-of-concept, neutralizing antibodies against one newly identified contributor, PODXL, inhibit CTC cluster formation and lung metastasis associated with paclitaxel treatment for triple-negative breast cancer.
Supplementary Figure 2 from MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids
Authors: Pickles Oliver J. , Wanigasooriya Kasun , Ptasinska Anetta , Patel Akshay J. , Robbins Helen L. , Bryer Claire , Whalley Celina M. , Tee Louise , Lal Neeraj , Pinna Claudia M.A. , Elzefzafy Nahla , Taniere Philippe , Beggs Andrew D. , Middleton Gary M.
Published: August 2023

RNA sequencing on unstimulated inducible vs non-inducible organoids. Gene Ontology Enrichment Analysis displayed for pathways upregulated in inducible (top) and non-inducible (bottom) organoids.
Figure S4 from Discovery and characterization of ZL-2201, a potent, highly selective, and orally bioavailable small-molecule DNA-PK inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X , Xia Shanghua , Zhang Haoyu , Parikh Nehal S , Ye Qiuping , Veiby O. Petter , Bellovin David I , Ji Yuhua
Published: August 2023

ZL-2201 treatment exhibits potent antitumor efficacy in vivo.
Figure S3 from Discovery and characterization of ZL-2201, a potent, highly selective, and orally bioavailable small-molecule DNA-PK inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X , Xia Shanghua , Zhang Haoyu , Parikh Nehal S , Ye Qiuping , Veiby O. Petter , Bellovin David I , Ji Yuhua
Published: August 2023

Kinetics of Bleomycin-induced DNA-PK phosphorylation by ZL-2201
Demethylation of EHMT1/GLP Protein Reprograms Its Transcriptional Activity and Promotes Prostate Cancer Progression
Authors: Besschetnova Anna , Han Wanting , Liu Mingyu , Gao Yanfei , Li Muqing , Wang Zifeng , Labaf Maryam , Patalano Susan , Venkataramani Kavita , Muriph Rachel E. , Macoska Jill A. , Siegfried Kellee R. , Evans Jason , Balk Steven P. , Gao Shuai , Han Dong , Cai Changmeng
Published: August 2023

Epigenetic reprogramming, mediated by genomic alterations and dysregulation of histone reader and writer proteins, plays a critical role in driving prostate cancer progression and treatment resistance. However, the specific function and regulation of EHMT1 (also known as GLP) and EHMT2 (also known as G9A), well-known histone 3 lysine 9 methyltransferases, in prostate cancer progression remain poorly understood. Through comprehensive investigations, we discovered that both EHMT1 and EHMT2 proteins have the ability to activate oncogenic transcription programs in prostate cancer cells. Silencing EHMT1/2 or targeting their enzymatic activity with small-molecule inhibitors can markedly decrease prostate cancer cell proliferation and metastasis in vitro and in vivo. In-depth analysis of posttranslational modifications of EHMT1 protein revealed the presence of methylation at lysine 450 and 451 residues in multiple prostate cancer models. Notably, we found that lysine 450 can be demethylated by LSD1. Strikingly, concurrent demethylation of both lysine residues resulted in a rapid and profound expansion of EHMT1’s chromatin binding capacity, enabling EHMT1 to reprogram the transcription networks in prostate cancer cells and activate oncogenic signaling pathways. Overall, our studies provide valuable molecular insights into the activity and function of EHMT proteins during prostate cancer progression. Moreover, we propose that the dual-lysine demethylation of EHMT1 acts as a critical molecular switch, triggering the induction of oncogenic transcriptional reprogramming in prostate cancer cells. These findings highlight the potential of targeting EHMT1/2 and their demethylation processes as promising therapeutic strategies for combating prostate cancer progression and overcoming treatment resistance.

Significance:

In this study, we demonstrate that EHMT1 and EHMT2 proteins drive prostate cancer development by transcriptionally activating multiple oncogenic pathways. Mechanistically, the chromatin binding of EHMT1 is significantly expanded through demethylation of both lysine 450 and 451 residues, which can serve as a critical molecular switch to induce oncogenic transcriptional reprogramming in prostate cancer cells.
Discovery and Characterization of ZL-2201, a Potent, Highly Selective, and Orally Bioavailable Small-molecule DNA-PK Inhibitor
Authors: Lal Shruti , Bhola Neil E. , Sun Bee-Chun , Chen Yuping , Huang Tom , Morton Vivian , Chen Kevin X. , Xia Shanghua , Zhang Haoyu , Parikh Nehal S. , Ye Qiuping , Veiby O. Petter , Bellovin David I. , Ji Yuhua
Published: August 2023

DNA-dependent protein kinase (DNA-PK), a driver of the non-homologous end-joining (NHEJ) DNA damage response pathway, plays an instrumental role in repairing double-strand breaks (DSB) induced by DNA-damaging poisons. We evaluate ZL-2201, an orally bioavailable, highly potent, and selective pharmacologic inhibitor of DNA-PK activity, for the treatment of human cancerous malignancies. ZL-2201 demonstrated greater selectivity for DNA-PK and effectively inhibited DNA-PK autophosphorylation in a concentration- and time-dependent manner. Initial data suggested a potential correlation between ataxia-telangiectasia mutated (ATM) deficiency and ZL-2201 sensitivity. More so, ZL-2201 showed strong synergy with topoisomerase II inhibitors independent of ATM status in vitro. In vivo oral administration of ZL-2201 demonstrated dose-dependent antitumor activity in the NCI-H1703 xenograft model and significantly enhanced the activity of approved DNA-damaging agents in A549 and FaDu models. From a phosphoproteomic mass spectrometry screen, we identified and validated that ZL-2201 and PRKDC siRNA decreased Ser108 phosphorylation of MCM2, a key DNA replication factor. Collectively, we have characterized a potent and selective DNA-PK inhibitor with promising monotherapy and combinatory therapeutic potential with approved DNA-damaging agents. More importantly, we identified phospho-MCM2 (Ser108) as a potential proximal biomarker of DNA-PK inhibition that warrants further preclinical and clinical evaluation.

Significance:

ZL-2201, a potent and selective DNA-PK inhibitor, can target tumor models in combination with DNA DSB-inducing agents such as radiation or doxorubicin, with potential to improve recurrent therapies in the clinic.
Driving Automation for Older Adults with Preclinical Alzheimer’s Disease
Authors: Ahmadnezhad Pedram , Burns Jeffrey M. , Akinwuntan Abiodun E. , Ranchet Maud , Kondyli Alexandra , Mahnken Jonathan D. , Devos Hannes
Published: August 2023

Introduction: Older adults with preclinical Alzheimer’s disease (AD) show changes in on-road driving performance. The impact of preclinical AD on using automated vehicle (AV) technology is unknown. The aim was to evaluate safety and cognitive workload while operating AV technology in drivers with preclinical AD. Introduction: This cross-sectional study included 40 participants: 19 older adults (age 74.16 ± 4.78; MOCA scores 26.42 ± 2.52) with preclinical AD, evidenced by elevated cortical beta-amyloid; and 21 controls (age 73.81 ± 5.62; MOCA scores 28.24 ± 1.67). All participants completed two scenarios in a driving simulator. Scenario 1 included conditional automation with an emergency event that required a manual take-over maneuver. Scenario 2 was identical but with a cognitive distractor task. Emergency response time was the main safety outcome measure. Cognitive workload was calculated using moment-to-moment changes in pupillary size and converted into an Index of Cognitive Activity (ICA). Mann-Whitney U and independent t tests were used to compare group differences. Results: Emergency response times were similar between drivers with preclinical AD and controls in scenario 1 (20.85 s ± 1.08 vs. 20.52 s ± 3.18; p = 0.83) and scenario 2 (14.83 s ± 7.37 vs. 13.45 s ± 10.43; p = 0.92). Likewise, no differences were found in ICA between drivers with preclinical AD and controls in scenario 1 (0.34 ± 0.08 vs. 0.33 ± 0.17; p = 0.74) or scenario 2 (0.30 ± 0.07 vs. 0.29 ± 0.17; p = 0.93). Conclusions: Older drivers with preclinical AD may safely operate AV technology, without increased response times or cognitive workload. Future on-road studies with AV technology should confirm these preliminary results in drivers with preclinical AD.
Fingernail Cortisol: A Biological Signal of Lifetime Major Depressive Disorder
Authors: Schumacher Sarah , Laufer Sebastian , Fischer Susanne
Published: August 2023

Introduction: Elevated levels of the hypothalamic-pituitary-adrenal axis hormone cortisol are a frequently replicated finding in major depressive disorder (MDD). However, the current state of research is inconclusive as to whether hypercortisolism represents a trait- or state-like biological signal of MDD. The aim of the present study was to investigate, for the first time, whether cortisol in fingernails, a highly accessible tissue, could distinguish currently remitted individuals with MDD from healthy controls. A further aim was to identify potential confounders of nail cortisol. Methods: A total of N = 100 individuals from the general population were recruited. A structured clinical interview was administered, which resulted in two groups: n = 48 with lifetime MDD and n = 52 healthy controls. All participants answered questions on sociodemographic, lifestyle, and psychosocial characteristics. They also grew their nails for 14 days and cut them for the subsequent determination of cortisol. Results: The groups differed in their nail cortisol concentrations, such that the individuals with lifetime MDD had significantly higher concentrations than the healthy controls (p = 0.041). Within the group of individuals with lifetime MDD, the number of experienced episodes was significantly correlated with cortisol (p = 0.011). Income emerged as the only significant confounder of cortisol (p = 0.008). Conclusion: Elevated fingernail cortisol appears to be a biological signal of MDD, even in the absence of a current major depressive episode. Its high accessibility and robustness render it a promising methodology for remote research as well as for the integration of biomarkers into clinical research and practice.
A Novel VACTERL Assessment Tool to Facilitate Counseling for Expectant Families
Authors: Riley John S. , Schomberg John , Mantha Aditya , Guner Yigit S. , Cuevas Amy , Stephenson Courtney D. , Peranteau William H. , Yu Peter T.
Published: August 2023

Introduction: VACTERL is defined as 3 or more of the following congenital defects: vertebral, anorectal, cardiac, tracheoesophageal (TE), renal, and limb. The purpose of this study was to create an easy-to-use assessment tool to help providers counsel expecting families regarding the likelihood of additional anomalies and postnatal outcomes. Methods: Employing the Kids’ Inpatient Database from 2003–2016, neonates (<29 days old) with VACTERL were identified using ICD-9-CM and ICD-10-CM codes. For each unique combination of VACTERL, multivariable logistic regression was used to estimate inpatient mortality, and Poisson regression was used to estimate length-of-stay during the initial hospitalization. Results: The assessment tool used in this study is available at https://choc-trauma.shinyapps.io/VACTERL. 1,886 of 11,813,782 (0.016%) neonates presented with VACTERL. 32% weighed <1,750 g, and 239 (12.7%) died prior to discharge. Associated with mortality were limb anomaly (1.8 [1.01–3.22], p < 0.05), prematurity (1.99 [1.14–3.47], p < 0.02), and weight <1,750 g (2.19 [1.25–3.82], p < 0.01). Median length-of-stay was 14 days (IQR: 7-32). Associated with increased length-of-stay were cardiac defect (1.47 [1.37–1.56], p < 0.001), vertebral anomaly (1.1 [1.05–1.14], p < 0.001), TE fistula (1.73 [1.66–1.81], p < 0.001), anorectal malformation (1.12 [1.07–1.16], p < 0.001), and weight <1,750 g (1.65 [1.57–1.73], p < 0.001). Conclusion: This novel assessment tool may help providers counsel families confronting a VACTERL diagnosis.
Large Ascites in a Cirrhotic Patient Reveal an Isolated and Late Metastasis of Ductal Breast Cancer: A Case Study
Authors: Mostafa Sherif , Habib Mhd Baraa , Ahmed Nada , Sawaf Bisher , Sadik Nagham , Abdalhadi Ahmed M.
Published: August 2023

Breast cancer is the most prevalent cancer in women worldwide, and its prevalence has increased since the introduction of screening programs. Most cases are discovered at an early stage; however, despite effective treatment, some cases progress to metastasis. The most common breast cancer metastatic locations are the bone, liver, and lungs. Ascites malignant due to peritoneal involvement is a rare manifestation of metastatic breast cancer. After 8 years of well-controlled breast cancer, we report a 54-year-old woman who presents with malignant ascites and is known to have cirrhosis of the liver.
Translation and Adaptation of the English Story Retell Procedure to Portuguese: A Preliminary Study
Authors: Ortiz Karin , Tognin Juliana , Medeiros Juliana Silveira Ferreira de , McNeil Malcom R.
Published: August 2023

Introduction: The comprehension and production of connected language are essential for effective communication. However, few assessment and intervention programs requiring connected language have been made available in Brazilian Portuguese. One connected language sampling procedure, the Story Retell Procedure (SRP), has been widely studied in English and primarily for people with aphasia. The SRP employs 12 stories, whose individual plots are quite different and still equivalent in terms of verbal productivity measures. The first objective of this study was to present the translation and adaptation of the SRP stories into Portuguese and to determine whether the translations are similar to English stories. The second objective was to analyze a small group of healthy adults’ responses to this assessment, thus observing whether the retellings of the SRP story forms in Portuguese would be similar to each other in the number of words, information units (IUs), and propositions – as demonstrated in English. Methods: This preliminary study translated and adapted into Portuguese, the 12 original English SRP stories. Only small cultural adaptations were made, preserving the essential content of the stories. The stories were then presented to 14 healthy adults, and the participants’ retellings from each story were compared to the other stories regarding the number of words, IUs, and propositions. Results: Few differences were found in the retellings considering the variables analyzed. Particularly, the retells of Gasolina (Gas), Biblioteca (Library), Empréstimo (Loan), Sanduíche (Sandwich), Futebol (Baseball), and Multas (Ticket) were not significantly different in the three aspects investigated in this study (percentages of words, IUs, and propositions). Conclusion: The SRP stories adapted to Portuguese, despite having a quite close number of words, IUs, and propositions to those in the original stories, did not result in retellings with similar number of words, IUs, or propositions across stories. Nonetheless, the parameters analyzed were not significantly different among the majority of the stories, and some were nearly identical. This study identified the SRP stories that can be equivalently used in assessment, reassessment, and possibly in the rehabilitation of patients with communication disorders. Likewise, differences must be considered when the stories are used with pathological populations.
Finnegans Wake 1.1: anew begins
Authors: Galindo Caetano Waldrigues
Published: August 2023

A full version of Finnegans Wake’s Book 1, Chapter 1, in Portuguese.
The Effect of Calcium Silicate–Based Materials on Tooth Discoloration and Evaluation of Color Change After Bleaching Treatment: A Spectrophotometric Study
Authors: Aksun Serpil Sağiroğlu , Ekici Mügem Aslı , Helvacioğlu Kivanç Bağdagül
Published: August 2023

Purpose: To evaluate tooth discoloration after the use of calcium silicate–based materials and to examine the effect of internal bleaching on tooth discoloration. Materials and Methods: The specimens were randomly divided into two experimental groups (n = 45) and a control group (n = 6). Cavities were filled with ProRoot MTA (Dentsply) in Group 1 and Biodentine (Septodont) in Group 2. Color measurements were taken with a spectrophotometer before and after the application of materials at 1 week and then at 13, and 6 months. After 6 months, Groups 1 and 2 were divided into three subgroups according to internal bleaching techniques. All color change ratios and lightness differences were calculated using the CIE L*a*b* system. Data were analyzed using repeated ANOVA and the Kruskal-Wallis test (P = .05). Results: There were statistically significant differences between Groups 1 and 2 at all time intervals (P < .05). Group 1 showed more discoloration than Group 2 (P < .05). There were no significant differences between the bleaching agents (P > .05). Additionally, specimens in both groups became lighter than their initial color (P < .05). Conclusion: Teeth treated with ProRoot MTA exhibited darkening at 1 week that increased over time, whereas those treated with Biodentine maintained the lightness for 6 months.
Clarification of the diagnosis of the genus Loxosoma s.l. (Entoprocta; Loxosomatidae) based on morphological and molecular data
Authors: BORISANOVA ANASTASIA , SCHEPETOV DIMITRY
Published: August 2023

Loxosomatidae are solitary entoprocts associated with various types of invertebrate hosts. Two genera are distinguished in the family Loxosomatidae, Loxosomella and Loxosoma, that have clear morphological differences in the attachment structures. Loxosoma attaches to the substratum by a muscular sucking pedal disk, which allows moving. Both kidneys and adults are thought to have a pedal disc throughout their lives. In August 2021, several specimens of loxosomatids were found in the White Sea at a depth of 30–70 m on a polychaete Laonice sp. (Spionidae), which were investigated using light and electron microscopy as well as molecular phylogenetic analysis. These loxosomatids were identified as Loxosomella aripes Nielsen, although a stalk of large buds of the specimens from the White Sea terminate with a pedal disc typical of Loxosoma. Molecular phylogenetic analysis of two markers [28S rRNA (~380bp) and 18S rRNA (in three parts totaling ~1850bp)] confirms the affinity of the species to Loxosoma s.l. and does not confirm monophyly of the genera Loxosoma and Loxosomella, indicating that the entire system of loxosomatids requires revision. Here, we redescribe the species Loxosomella aripes as Loxosoma s.l. aripes. The diagnosis of the genus Loxosoma s.l. is supplemented with the observation that the structure of the attachment organ can change after anchoring to the substrate. A list of species currently assigned to Loxosomella that may in fact belong to the genus Loxosoma s.l. is also given.
A new species of Arthromelodes Jeannel from Okinawa-jima, Japan (Coleoptera, Staphylinidae, Pselaphinae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: August 2023

To date, twenty species and subspecies of Arthromelodes Jeannel were known to occur in Japan, distributed in Honshȗ, Kyȗshȗ, Shikoku, Yakushima, and Amami Islands. No species have been recorded from central or southwestern Ryȗkyȗ. Arthromelodes tokushigei sp. n., the first species known to inhabit Okinawa Island of the central Ryȗkyȗ is described. This wingless species seems to be restricted to the northern Yambaru forest of Okinawa. In order to facilitate future studies on Arthromelodes and related, poorly-defined genera of Batrisini, detailed morphological documentation of the new species is provided.
A palearctic bark beetle, Crypturgus hispidulus Thomson (Coleoptera: Curculionidae: Scolytinae), new to North America discovered in New England, U.S.A.
Authors: DIGIROLOMO MARC F. , SEVIGNY JOSEPH L.
Published: August 2023

Specimens of a bark beetle, Crypturgus hispidulus Thomson, 1870, were discovered in New England, U.S.A. This is the first record of this species established in North America. Misidentified specimen records were found from multiple states in different years, confirming establishment of the species in the Northeastern United States. The morphology is presented and a modified key to Crypturgus in North America is provided to facilitate species identification.
Seabirds in the North-East Atlantic
Authors: Häkkinen Henry , Petrovan Silviu O. , Taylor Nigel G. , Sutherland William J. , Pettorelli Nathalie
Published: August 2023

This book was produced by the Zoological Society of London and the University of Cambridge with two aims: to assess seabirds’ vulnerability to climate change in the North-East Atlantic, and to identify potential conservation actions that could reduce this vulnerability.

'Seabirds in the North-East Atlantic' collates information from the scientific literature, non-governmental organisations’ reports, conservation practitioner input and online databases into a single volume, and provides a reference manual to assist conservation planning. It is intended to be used by anyone who wishes to identify climate change threats to seabirds; to compare threats between different areas of the North-East Atlantic; to start a quantitative climate change vulnerability assessment for a local population; or to review options for conservation action in response to climate change.

This book stems from research published in December 2022, but assessments may be updated based on feedback and newly available information. To check for updates to our assessments, please visit our website at: www.ZSL.org/seabird-guidelines.
5. Loons/Divers and Grebes (Gaviidae and Podicipedidae)
Authors: Häkkinen Henry , Petrovan Silviu O. , Taylor Nigel G. , Sutherland William J. , Pettorelli Nathalie
Published: August 2023

With key information linked to thematic maps, this section evaluates the climate change vulnerability of five species of loons/divers and grebes (Gaviidae and Podicipedidae) – Arctic Loon, Common Loon, Red-Throated Loon, Horned Grebe, and Red-necked Grebe – in the North-East Atlantic. The assessments for every species cover three categories each: the exposure, or the magnitude in percentage and the characteristics of climate change; the sensitivity, or how much and by which climatic events the species are affected, depending on their biological features; the adaptive capacity, or the potential of species to respond to climate change.

Updates to this section will follow, as the impacts of climate change on loons/divers and grebes are currently unidentified.
8. Terns (Laridae)
Authors: Häkkinen Henry , Petrovan Silviu O. , Taylor Nigel G. , Sutherland William J. , Pettorelli Nathalie
Published: August 2023

With key information linked to thematic maps, this section evaluates the climate change vulnerability of five terns (Laridae) species – Arctic Tern, Little Tern, Roseate Tern, Sandwich Tern, and Caspian Tern – in the North-East Atlantic. The assessments for every species cover three categories each: the exposure, or the magnitude in percentage and the characteristics of climate change; the sensitivity, or how much and by which climatic events the species are affected, depending on their biological features; the adaptive capacity, or the potential of species to respond to climate change.

Assessments of local conservation actions that can be implemented to reduce climate change impacts are listed here in readily consultable tables. This section focuses on the effectiveness of interventions to limit reduced prey availability and the destruction of terns’ nests caused by storms. Criteria of relevance, strength, and transparency measure the effectiveness of the actions.
Evaluation of WRF Model Boundary Layer Schemes in Simulating Temperature and Heat Extremes over the Middle East–North Africa (MENA) Region
Authors: Ntoumos Athanasios , Hadjinicolaou Panos , Zittis George , Constantinidou Katiana , Tzyrkalli Anna , Lelieveld Jos
Published: August 2023

We assess the sensitivity of the Weather Research and Forecasting (WRF) Model to the use of different planetary boundary layer (PBL) parameterizations focusing on air temperature and extreme heat conditions. This work aims to evaluate the performance of the WRF Model in simulating temperatures across the Middle East–North Africa (MENA) domain, explain the model biases resulting from the choice of different PBL schemes, and identify the best-performing configuration for the MENA region. Three different PBL schemes are used to downscale the ECMWF ERA-Interim climate over the MENA region at a horizontal resolution of 24 km, for the period 2000–10. These are the Mellor–Yamada–Janjić (MYJ), Yonsei University (YSU), and the asymmetric convective model, version 2 (ACM2). For the evaluation of the WRF runs, we used related meteorological variables from the ERA5 reanalysis, including summer maximum and minimum 2-m air temperature and heat extreme indices. Our results indicate that simulations tend to overestimate maximum temperatures and underestimate minimum temperatures, and we find that model errors are very dependent on the geographic location. The possible physical causes of model biases are investigated through the analysis of additional variables (such as boundary layer height, moisture, and heat fluxes). It is shown that differences among the PBL schemes are associated with differences in vertical mixing strength, which alters the magnitude of the entrainment of free-tropospheric air into the PBL. The YSU is found to be the best-performing scheme, and it is recommended in WRF climate simulations for the MENA region.
A Moist Potential Vorticity Model for Midlatitude Long-Lived Mesoscale Convective Systems over Land
Authors: Yang Qiu , Leung L. Ruby , Feng Zhe , Chen Xingchao
Published: August 2023

Mesoscale convective systems (MCSs) bring large amounts of rainfall and strong wind gusts to the midlatitude land regions, with significant impacts on local weather and hydrologic cycle. However, weather and climate models face a huge challenge in accurately modeling the MCS life cycle and the associated precipitation, highlighting an urgent need for a better understanding of the underlying mechanisms of MCS initiation and propagation. From a theoretical perspective, a suitable model to capture the realistic properties of MCSs and isolate the bare-bones mechanisms for their initiation, intensification, and eastward propagation is still lacking. To simulate midlatitude MCSs over land, we develop a simple moist potential vorticity (PV) model that readily describes the interactions among PV perturbations, air moisture, and soil moisture. Multiple experiments with or without various environmental factors and external forcing are used to investigate their impacts on MCS dynamics and mesoscale circulation vertical structures. The result shows that mechanical forcing can induce lower-level updraft and cooling, providing favorable conditions for MCS initiation. A positive feedback among surface winds, evaporation rate, and air moisture similar to the wind-induced surface heat exchange over tropical ocean is found to support MCS intensification. Both background surface westerlies and vertical westerly wind shear are shown to provide favorable conditions for the eastward propagation of MCSs. Last, our result highlights the crucial role of stratiform heating in shaping mesoscale circulation response. The model should serve as a useful tool for understanding the fundamental mechanisms of MCS dynamics.
Regimes of Soil Moisture–Wet-Bulb Temperature Coupling with Relevance to Moist Heat Stress
Authors: Kong Qinqin , Huber Matthew
Published: August 2023

Human heat stress depends jointly on atmospheric temperature and humidity. Wetter soils reduce temperature but also raise humidity, making the collective impact on heat stress unclear. To better understand these interactions, we use ERA5 to examine the coupling between daily average soil moisture and wet-bulb temperature (Tw) and its seasonal and diurnal cycle at global scale. We identify a global soil moisture–Tw coupling pattern with both widespread negative and positive correlations in contrast to the well-established cooling effect of wet soil on dry-bulb temperature. Regions showing positive correlations closely resemble previously identified land–atmosphere coupling hotspots where soil moisture effectively controls surface energy partition. Soil moisture–Tw coupling varies seasonally closely tied to monsoon development, and the positive coupling is slightly stronger and more widespread during nighttime. Local-scale analysis demonstrates a nonlinear structure of soil moisture–Tw coupling with stronger coupling under relatively dry soils. Hot days with high Tw values show wetter-than-normal soil, anomalous high latent and low sensible heat flux from a cooler surface, and a shallower boundary layer. This supports the hypothesis that wetter soil increases Tw by concentrating surface moist enthalpy flux within a shallower boundary layer and reducing free-troposphere-air entrainment. We identify areas of particular interest for future studies on the physical mechanisms of soil moisture–heat stress coupling. Our findings suggest that increasing soil moisture might amplify heat stress over large portions of the world including several densely populated areas. These results also raise questions about the effectiveness of evaporative cooling strategies in ameliorating urban heat stress.

Significance Statement

The purpose of this study is to provide a global picture of the relationship between soil moisture anomalies and a heat stress metric that includes the joint effects of temperature and humidity. This is important because a better understanding of this relationship will help improve the prediction of extreme heat stress events and inform strategies for ameliorating heat stress. We find a widespread positive correlation between soil moisture and heat stress, in contrast to studies relying on temperature alone. This raises the possibility that, over much of the world, and in the most populous regions, strategies like irrigation or “greening” that can reduce temperature might be ineffective or even harmful in reducing heat stress with humidity incorporated.
Modelling and continuous stiffness control of robot with compliant wrist for misalignment shaft-hole assembly
Authors: Xu Du , Hu Tete
Published: August 2023

In this paper, a continuously variable stiffness control strategy for shaft-hole assembly with a compliant wrist is proposed. The compliant wrist adjusts stiffness by changing the cantilever length of a super-elastic Ni-Ti wire. Its core idea is that when the contact force of the robot exceeds a particular value, the wrist adjusts the stiffness and can deform in a specific direction that guarantees assembly, allows a relatively significant misalignment, and produces a small force. The advantage of the proposed strategy is that the shaft-hole assembly status is supervised by calculating the deformation of compliant wrist based on contact force information, this significantly decrease the requirements of shaft-hole alignment accuracy. On this basis, the kinetostatic coupling kinematic and static force model is built and the fuzzy PD stiffness control strategy is designed to realize the desired stiffness of the wrist in various directions. Finally, the shaft-hole assembly experiments under different misalignment error demonstrates the reliability of the wrist, indicating the efficacy of the control method.
Does Rational Choice Help to Explain Offending Differences Across Immigrant Generations? Focusing on Serious Adolescent Offenders
Authors: Han Sungil , Piquero Alex R. , Bersani Bianca E.
Published: August 2023

Objectives: Accumulating research finds that immigrants are less likely to offend compared to their native-born counterparts in the United States. Less understood are the factors that help account for this disparity in offending. Because there are reasons to believe that immigrants weigh the costs and benefits of crime differently than their U.S.-born peers, we explore the utility of a rational choice perspective to explain the disparity in offending across immigrant generations. Methods: Utilizing data from the Pathways to Desistance Study, multilevel mixed effects models are employed to assess if perceptions of rewards and costs of crime help explain differences in offending trajectories and desistance across immigrant status. Results: Rational choice-related variables emerge as significant predictors of offending and help to explain, in part, why first-generation immigrants are less likely to offend. In particular, the perceived risk of arrest appears to play a key role and interacts with immigrant status. Conclusions: The results from this research suggest that first-generation immigrants with a higher perceived risk of arrest reported lower offending compared to second- and third-plus-generation youth. We consider the theoretical implications of the rational choice perspective to explain the divergence in offending across immigrant generation groups.
Guess the Right Word: A Review of the Language Game Wordle
Authors: Kwan Yu Hang
Published: August 2023

The value of language games has been embraced in language learning, yet it is crucial to evaluate these games and consider pedagogical mediations that may leverage their language learning potentials. Taking this need into consideration, this article reviews the once-a-day-only online word-guessing game, Wordle, by commenting on its design features and educational value. This review also offers some suggestions on maximizing the affordances of the game on learners’ and teachers’ sides.
Household’s Stressors and Well-Being During the Global COVID-19 Pandemic
Authors: Balsa Ana , Bloomfield Juanita , Cid Alejandro , Lorenzo Martina , Patrone Paula
Published: August 2023

Home environments suffered a range of stressors during COVID-19 pandemic. This study examines the impact of these stressors on children’s well-being by households’ conditions. Participants included main caregivers ( N = 615) with a child under the age of 3 in a developing Latin-American country. We use multivariate analysis to explore associations between these shocks, the childrearing environment, and children’s well-being. We find that households with lower education and recipients of government assistance were more exposed to negative shocks linked to COVID-19. However, the most educated households were more likely to face an increased burden of childcare. Exposure to negative shocks was associated with a deterioration in the emotional well-being of adults, a higher prevalence of intra-family violence, and behavioral changes in children. Households that reported more time spent caring for children, as well as difficulties in combining care and work, showed higher levels of parental depression and worse indicators of parenting quality. We observe a drop in the frequency of parental involvement in didactic and socializing activities with their children, and a poorer mental health status for the main caregiver (mostly mothers).