bluuebunny/crossref_metadata_2025 huggingface dataset:
Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β‐catenin, and Twist pathways
Authors: Yang Yi‐Chen , Chiou Pei‐Chen , Chen Po‐Chun , Liu Po‐Yi , Huang Wei‐Chien , Chao Chia‐Chia , Tang Chih‐Hsin
Published: November 2018

Lung cancer is one of the most common cancer in cancer‐related deaths worldwide, which is characterized by its strong metastatic potential. The melatonin hormone secreted by the pineal grand has an antioxidant effect and protects cells against carcinogenic substances. However, the effects of melatonin in lung cancer stemness are largely unknown. We found that melatonin reduces CD133 expression by ~50% in lung cancer cell lines, while results of a sphere formation assay showed that melatonin inhibits lung cancer stemness. These effects of melatonin were reversed when the cell lines were incubated with phospholipase C (PLC), ERK/p38, and a β‐catenin activator. Transfection with Twist siRNA augmented the inhibitory effects of melatonin, indicating that melatonin suppresses lung cancer stemness by inhibiting the PLC, ERK/p38, β‐catenin, and Twist signaling pathways. We also found CD133 expression is positively correlated with Twist expression in lung cancer specimens. Melatonin shows promise in the treatment of lung cancer stemness and deserves further study.
Non-Abelian anomalous (super)fluids in thermal equilibrium from differential geometry
Authors: Mañes Juan L. , Megías Eugenio , Valle Manuel , Vázquez-Mozo Miguel Á.
Published: November 2018

Abstract

We apply differential geometry methods to the computation of the anomaly-induced hydrodynamic equilibrium partition function. Implementing the imaginary-time prescription on the Chern-Simons effective action on a stationary background, we obtain general closed expressions for both the invariant and anomalous part of the partition function. This is applied to the Wess-Zumino-Witten action for Goldstone modes, giving the equilibrium partition function of superfluids. In all cases, we also study the anomaly-induced gauge currents and energy-momentum tensor, providing explicit expressions for them.
Epic failure: Lessons learned from interprofessional faculty development
Authors: Doll Joy , Maio Anna , Potthoff Meghan
Published: November 2018

Interprofessional education (IPE) is now recognized as an important initiative to prepare the next generation of health providers. Although IPE has been embraced by many institutions, faculty development still remains an issue. In this manuscript, the authors share their story of one attempt to educate a variety of health science faculty on IPE in what was perceived as an approachable venue. The story of its epic failure and lessons learned will be shared to help others avoid similar pitfalls.
Reviewing the Marketing Theory Adoption Journey for Studies Using QCA as a Methodological Approach: Insights, Gaps and Agenda for Future Research
Authors: De Villiers R. , Tipgomut P.
Published: November 2018

This study identifies how complex real-world marketing phenomena have been reported since the introduction of Qualitative Comparative Analysis (QCA) as a methodology and set of data analysis and theory development tools in 1987. We provide insights into the idea adoption journey as reflected by marketing researchers’ published studies in 216 marketing-related articles across A- and A*-ranked marketing journals from 1988-2018. We find that QCA as a methodology and a set of tools is not yet firmly established in academic marketing literature. The paper identifies gaps, not covered in the extant literature, in the adoption stages of QCA as a research methodology. The paper suggests some research areas that need to be addressed to help inform improvements in marketing research practice. The paper extends both methodology and marketing research by reconciling insights from a fragmented emerging literature, and highlights the dynamics and interrelationships in the extant literature.
Apolipoprotein E particle size is increased in Alzheimer's disease
Authors: Nelson Thomas J. , Sen Abhik
Published: November 2018

Introduction

Apolipoprotein E4 (apoE4) is the predominant risk factor for late‐onset Alzheimer's disease (AD), but the question of which structural differences might explain its effect remains unclear.

Methods

We compared high‐density lipoprotein–like apoE particles from 12 AD and 10 control patients using size‐exclusion chromatography.

Results

ApoE particles from patients genotyped as ε4/ε4 were 2.2 ± 0.3 times as massive as particles from ε3/ε3 control subjects and 1.4 ± 0.1 times as massive as particles from ε3/ε3 AD patients. The increased particle size was not because of incorporation of amyloid β or apoE proteolysis products. Particles from AD patients genotyped as ε3/ε3 were 1.59 ± 0.27 times as massive as ε3/ε3 control subjects.

Discussion

Increased particle size in AD is affected by APOE genotype and by disease‐related differences in assembly or stability. These differences suggest that lipoprotein assembly or stability in AD brain plays an important role in determining apoE4 pathogenicity.
The Political Origins of Professional Identity: Lawyers, Judges, and Prosecutors in Taiwan’s State Transformation
Authors: HSU Ching-fang
Published: November 2018

Where does the legal profession’s identity originate from? How do we explain the intra-professional variations, as multiple legal professions diverge in their political orientations? This paper argues that the legal profession critically develops their core identity resisting incumbent rulewhenthe state undergoes fundamental power reconfiguration. It is their political position as opposed to power in a critical juncture of state transformation that determines the legal profession’s collective ideal of who they are and what actions they take. Drawing on 133 interviews with Taiwanese judges, lawyers, and prosecutors, extensive fieldwork, and archival data up to the 1990s, this paper demonstrates how democratization shapes professional identity. As respective professions experienced different levels and models of authoritarian containment, they took separate trajectories to challenge the Kuomintang’s party-state and pledge to different normative commitments. Taiwanese judges categorically defend judicial independence, lawyers advocate for people’s rights, and prosecutors marshal under justice to check abuse of power.
The Process of Patient Engagement in Cardiac Rehabilitation: A Model-Centric Systematic Review
Authors: Jahandideh Sepideh , Kendall Elizabeth , Low-Choy Samantha , Donald Kenneth , Jayasinghe Rohan
Published: November 2018

This study aimed to compile existing evidence about the proposed relationships among variables at three stages of the model of therapeutic engagement (MTE): patient intention to engage in cardiac rehabilitation (CR), CR initiation, and sustained engagement. This model has not been tested in any rehabilitation setting. Therefore, this systematic literature review is key to future research and application of MTE to predict and enhance patient engagement in CR. Model-centric systematic literature reviews have been conducted for each stage of the MTE. A coherent approach to understanding and monitoring the process of patient engagement in CR is absent. Few relevant studies included in the model-centric reviews met the criteria: eight in stage 1, four in stage 2, and six in stage 3 of the MTE. In total, the tenets of the MTE were supported in patient intention to engage in CR. However, there was less evidence quantifying the proposed relationships among variables that impact on CR initiation and sustained engagement. There is a scarcity of research examining rehabilitation engagement in depth to better understand the complicated process contributing to behavioural outcomes. No decision-support models currently exist to alert patients and healthcare provider to the factors that influence non-engagement.
Transmission of Staphylococcus aureus from dry surface biofilm (DSB) via different types of gloves
Authors: Tahir Shamaila , Chowdhury Durdana , Legge Mark , Hu Honghua , Whiteley Greg , Glasbey Trevor , Deva Anand K. , Vickery Karen
Published: November 2018

Background

Pathogens can survive for extended periods when incorporated into biofilm on dry hospital surfaces (ie, dry-surface biofilm, DSB). Bacteria within biofilm are protected from desiccation and have increased tolerance to cleaning agents and disinfectants.

Objective

We hypothesized that gloved hands of healthcare personnel (HCP) become contaminated with DSB bacteria and hence may transmit bacteria associated with healthcare-associated infections (HAIs).

Method

Staphylococcus aureus DSB was grown in vitro on coupons in a bioreactor over 12 days with periodic nutrition interspersed with long periods of dehydration. Each coupon had ~107 DSB bacterial cells. Transmission was tested with nitrile, latex, and surgical gloves by gripping DSB-covered coupons then pressing finger tips onto a sterile horse blood agar surface for up to 19 consecutive touches and counting the number of colony-forming units (CFU) transferred. Coupons were immersed in 5% neutral detergent to simulate cleaning, and the experiment was repeated.

Results

Bacterial cells were readily transmitted by all 3 types of gloves commonly used by HCP. Surprisingly, sufficient S. aureus to cause infection were transferred from 1 DSB touch up to 19 consecutive touches. Also, 6 times more bacteria were transferred by nitrile and surgical gloves than to latex gloves (P <.001). Treating the DSB with 5% neutral detergent increased the transmission rate of DSB bacteria 10-fold.

Conclusion

Staphylococcus aureus incorporated into environmental DSB and covered by extracellular polymeric substances readily contaminates gloved hands and can be transferred to another surface. These results confirm the possibility that DSB contributes to HAI acquisition.
When and Why? The Chronology and Context of Flint Mining at Grime’s Graves, Norfolk, England
Authors: Healy Frances , Marshall Peter , Bayliss Alex , Cook Gordon , Bronk Ramsey Christopher , van der Plicht Johannes , Dunbar Elaine
Published: November 2018

New radiocarbon dating and chronological modelling have refined understanding of the character and circumstances of flint mining at Grime’s Graves through time. The deepest, most complex galleried shafts were worked probably from the third quarter of the 27th century calbcand are amongst the earliest on the site. Their use ended in the decades around 2400 calbc, although the use of simple, shallow pits in the west of the site continued for perhaps another three centuries. The final use of galleried shafts coincides with the first evidence of Beaker pottery and copper metallurgy in Britain. After a gap of around half a millennium, flint mining at Grime’s Graves briefly resumed, probably from the middle of the 16th century calbcto the middle of the 15th. These ‘primitive’ pits, as they were termed in the inter-war period, were worked using bone tools that can be paralleled in Early Bronze Age copper mines. Finally, the scale and intensity of Middle Bronze Age middening on the site is revealed, as it occurred over a period of probably no more than a few decades in the 14th century calbc. The possibility of connections between metalworking at Grime’s Graves at this time and contemporary deposition of bronzes in the nearby Fens is discussed.
The Credibility of Public and Private Signals: A Document-Based Approach
Authors: KATAGIRI AZUSA , MIN ERIC
Published: November 2018

Crisis bargaining literature has predominantly used formal and qualitative methods to debate the relative efficacy of actions, public words, and private words. These approaches have overlooked the reality that policymakers are bombarded with information and struggle to adduce actual signals from endless noise. Material actions are therefore more effective than any diplomatic communication in shaping elites’ perceptions. Moreover, while ostensibly “costless,” private messages provide a more precise communication channel than public and “costly” pronouncements. Over 18,000 declassified documents from the Berlin Crisis of 1958–63 reflecting private statements, public statements, and White House evaluations of Soviet resolve are digitized and processed using statistical learning techniques to assess these claims. The results indicate that material actions have greater influence on the White House than either public or private statements; that public statements are noisier than private statements; and that private statements have a larger effect on evaluations of resolve than public statements.
Swampy Sugar Lands: Irrigation Dams and the Rise and Fall of Malaria in Puerto Rico, 1898–1962
Authors: Johnson Matthew P.
Published: November 2018

Two environmental re-engineering projects clashed in south-eastern Puerto Rico in the early twentieth century. Between 1910 and 1914 the Puerto Rican Irrigation Service built three large dams to water canefields owned by US sugar companies. The new canals and holding ponds created ideal breeding grounds for malaria-carrying mosquitoes, and demand for fieldworkers encouraged greater numbers of Puerto Ricans to work and live near these mosquito swarms. Malaria rates soared as a result. Meanwhile, public health officials tried to control malaria, but their efforts faltered, especially when efficient irrigation was prioritised above all else. It was not until the 1940s and 1950s that health officials controlled and then eliminated malaria. In Puerto Rico, malaria rose with the commitment to irrigated canefields and remained tenacious until wartime exigencies inspired greater control efforts, DDT became available and, most importantly, manufacturing eclipsed sugar production as the island's dominant economic activity.
Analytic slowing-down distributions as modified by turbulent transport
Authors: Wilkie G. J.
Published: November 2018

The effect of electrostatic microturbulence on fast particles rapidly decreases at high energy, but can be significant at moderate energy. Previous studies found that, in addition to changes in the energetic particle density, this results in non-trivial changes to the equilibrium velocity distribution. These effects have implications for plasma heating and the stability of Alfvén eigenmodes, but make multiscale simulations much more difficult without further approximations. Here, several related analytic model distribution functions are derived from first principles. A single dimensionless parameter characterizes the relative strength of turbulence relative to collisions, and this parameter appears as an exponent in the model distribution functions. Even the most simple of these models reproduces key features of the numerical phase-space transport solution and provides a useful a priori heuristic for determining how strong the effect of turbulence is on the redistribution of energetic particles in toroidal plasmas.
Childhood determinants of suicidality: comparing males in military and civilian employed populations
Authors: Syed Sheriff Rebecca , Van Hooff Miranda , Malhi Gin , Grace Blair , McFarlane Alexander
Published: November 2018

Background

To better understand the associations of childhood trauma and childhood disorder with past-year suicidality (thoughts, plans or attempts), we compared male military and civilian populations aged 18–60 years old.

Methods

Data derived from the 2010 Australian Defence Force (ADF) Mental Health Prevalence and Wellbeing Study and the 2007 Australian Bureau of Statistics Australian National Survey of Mental Health and Wellbeing were compared using logistic regression and Generalized Structural Equation Modelling (GSEM).

Results

A greater proportion of the ADF experienced suicidality than civilians. Those who experienced childhood trauma that was not interpersonal in nature were not at increased odds of suicidality, in either population. A higher proportion of the ADF experienced three or more types of trauma in childhood and first experienced three or more types of trauma in adulthood. Both were associated with suicidality in the ADF and civilians. Childhood anxiety had a strong and independent association with suicidality in the ADF (controlling for demographics and childhood trauma, adult trauma and adult onset disorder). Childhood anxiety fully mediated the relationship between childhood trauma and suicidality in the ADF, but not in civilians.

Conclusions

These data highlight the need to take a whole life approach to understanding suicidality, and the importance of categorizing the nature of childhood trauma exposure. Importantly, childhood anxiety was not only associated with suicidality, it fully mediated the relationship between childhood trauma and suicidality in the more trauma exposed (military) population only. These findings have the potential to inform the development of strategies for suicide prevention.
Perceptions of ageing and future aspirations by people with intellectual disability: a grounded theory study using photo-elicitation
Authors: Trip Henrietta , Whitehead Lisa , Crowe Marie
Published: November 2018

Internationally, 1 per cent of the general population are living with an intellectual disability and life expectancy is increasing in line with global trends. The majority of people with an intellectual disability live with family. This represents a growing and largely ‘hidden’ population who have, or will have, additional needs as they and their family age. There is limited research about what is important for people with intellectual disability when thinking about getting older. This article reports on a study which explored the concept of ageing and future aspirations with 19 people living with an intellectual disability, aged 37–58 years of age (mean 48 years) and living with someone they identify as family. Using Charmaz's constructivist grounded theory approach and photo-elicitation, constant comparative analysis generated four themes: reciprocating relationships, emerging (in)dependence, configuring ageing and entertaining possibilities. As part of the interview process, photo-elicitation facilitated the expression of associations and perspectives about ageing and conceptualising the future for participants. The findings demonstrate the engagement of people with intellectual disabilities in research and provided unique insights into both their experiences and perspectives on ageing in the context of family. The need for greater flexibility in service planning and delivery are identified, alongside ensuring the meaningful inclusion of people with intellectual disability in decision-making about their own lives as they age.
From zero to ‘you’ and back: A mixed methods study comparing the use of two open personal constructions in Finnish
Authors: Varjo Mikael , Suomalainen Karita
Published: November 2018

This article focuses on two Finnish personal constructions which can be used to create indexically open reference, i.e. they can be used to refer to generalized or shared human experiences. These two constructions are the zero-person construction and the open 2nd person singular construction. Using Finnish everyday conversational data, we (i) statistically analyze the distributional semantico-grammatical differences in the use of the zero-person and open 2nd person singular constructions, and (ii) examine these differences on a clausal and sequential level in interactional contexts. In our analysis, we integrate quantitative and qualitative methods. Our aim is to show that by mixing methods it is possible to both reveal the recurring semantico-grammatical patterns of the constructions across a large corpus and analyze how these patterns are shaped by the ongoing interaction.
How differing methods of ascribing ethnicity and socio-economic status affect risk estimates for hospitalisation with infectious disease
Authors: Hobbs Mark R. , Atatoa Carr Polly , Fa'alili-Fidow Jacinta , Pillai Avinesh , Morton Susan M. B. , Grant Cameron C.
Published: November 2018

Significant ethnic and socio-economic disparities exist in infectious diseases (IDs) rates in New Zealand, so accurate measures of these characteristics are required. This study compared methods of ascribing ethnicity and socio-economic status. Children in the Growing Up in New Zealand longitudinal cohort were ascribed to self-prioritised, total response and single-combined ethnic groups. Socio-economic status was measured using household income, and both census-derived and survey-derived deprivation indices. Rates of ID hospitalisation were compared using linked administrative data. Self-prioritised ethnicity was simplest to use. Total response accounted for mixed ethnicity and allowed overlap between groups. Single-combined ethnicity required aggregation of small groups to maintain power but offered greater detail. Regardless of the method used, Māori and Pacific children, and children in the most socio-economically deprived households had a greater risk of ID hospitalisation. Risk differences between self-prioritised and total response methods were not significant for Māori and Pacific children but single-combined ethnicity revealed a diversity of risk within these groups. Household income was affected by non-random missing data. The census-derived deprivation index offered a high level of completeness with some risk of multicollinearity and concerns regarding the ecological fallacy. The survey-derived index required extra questions but was acceptable to participants and provided individualised data. Based on these results, the use of single-combined ethnicity and an individualised survey-derived index of deprivation are recommended where sample size and data structure allow it.
Human papillomaviruses 16 and 58 are distributed widely among women living in Shanghai, China, with high-grade, squamous intraepithelial lesions
Authors: Xu J. , Xia Z. , Wang L. , Yang B. , Zhu Y. , Zhu X. , Xu L.
Published: November 2018

The distribution of human papillomaviruses (HPVs) must be understood for the control and prevention of cervical cancer. Community-based Papanicolaou and HPV DNA tests were performed on 41 578 women. The prevalences of HPV genotypes 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 and 68 were assessed. In total, 10% women were infected/co-infected by these HPVs. The infection rate increased from 7.1% in women aged ⩽30 years to 10.4% in those aged 50–60 years, and then decreased slightly to 9.9% in those aged >60 years. The HPV 16 and 58 positivity rates were significantly higher among women with high-grade squamous intraepithelial lesions (HSILs) than among those with cervicitis/negativity for intraepithelial lesion or malignancy (NILM) or low-grade SILs (LSILs). The HPV 18, 52 and 68 infection rates were significantly lower in women with HSILs than in those with NILM or LSILs. The proportion of women infected by multiple HPV strains was higher among those with HSILs. The proportions of the five most common genotypes, HPV 16, 18, 33, 52 and 58, increased with the number of co-infecting strains. HPV 16 and 58 were the high-risk HPVs in the Shanghai community and should be the focus in HPV screening and vaccination.
In vivo storage of oocytes leads to lower survival, increased abnormalities and may affect the ploidy status in the yellowtail tetra Astyanax altiparanae
Authors: do Nascimento Nivaldo Ferreira , Lázaro Talita Maria , de Alcântara Nathalia Raissa , Rocha  , Senhorini José Augusto , dos Santos Silvio Carlos Alves , Nakaghi Laura Satiko Okada , Yasui George Shigueki
Published: November 2018

In this study we analyzed whether the in vivo storage of oocytes (time after ovulation until fertilization) affects the survival and the ploidy status of the yellowtail tetra Astyanax altiparanae. Fish were induced to spawn and, after ovulation, a small aliquot was stripped and immediately fertilized (positive control group). Subsequently, aliquots (~150 oocytes) were stripped and fertilized at various time points of 60, 120, 180 or 240 min. Developmental stages, abnormalities, survival and the ploidy status of the hatched larvae were examined. As expected, in the control group, 100% of the larvae were diploid. Conversely, triploid individuals were observed just at the 60 min treatment time point (0.6%). In vivo storage of oocytes also influenced the survival rates (P < 0.05); the 180 and 240 min samples, respectively, presented lower survival rates at gastrula (50.10±6.26% and 40.92±5.32%), and somite (17.80±5.14% and 4.41±2.76%) stages and lower hatching rates (12.01±4.04% and 4.41±2.76%). A higher percentage (99.27±0.40%) of normal larvae and only a few abnormal larvae (0.73±0.40%) were observed in the control group (P = 0.0000). This observation did not differ from that observed at the 60 min treatment point (P = 0.9976). A significant increase in the percentage of abnormalities was observed in the other treatments, and, after 240 min, the highest percentage of abnormal larvae was seen (P=0.0024; 83.33±16.67%). In conclusion, we showed that oocyte ageing had a significant effect on survival and may affect the ploidy status in A. atiparanae.
Different Levels of Government, Different Levels of Political Competence?
Authors: Chou Mark
Published: November 2018

In federal political systems such as the United States, there has long existed a view that citizens should be more politically competent at the local level than at the federal level of government. Recent studies have challenged this view. This article argues that these findings may reflect only one part of the broader picture. Through a review of two recent studies, I contend that research in this realm must consider more than only the level of government. Odd as this sounds, assumptions about varying levels of political competence at different levels of government have always been premised on the notion that local-level politics is smaller and less complex than federal-level politics. However, when local politics takes place today against the backdrop of small villages and towns as well as in large cities, these are assumptions that must be reevaluated.
Persian Poetry, Sufism and Ismailism: The Testimony of Khwājah Qāsim Tushtarī’sRecognizing God
Authors: VIRANI SHAFIQUE N.
Published: November 2018

Khwājah Qāsim Tushtarī’s recently discovered Recognizing God (Maʿrifat-i Khudāy taʿālā) is one of the only texts known to have survived from the early Alamūt period of Ismaili Muslim history. This article analyses the work in the context of the “new Invitation” (daʿwat-i jadīd) to the Ismaili faith that al-Shahrastānī (d. 548/1153) tells us was inaugurated by the Fāṭimid Imam al-Mustanṣir billāh (d. 487/1094) and championed by Ḥasan-i Ṣabbāḥ (d. 518/1124). The text emphasises that the ultimate purpose of human existence is to know God, and that the path to this knowledge is through the Imam of the Time. The concepts of the ‘true teacher’ (muʿallim-i ṣādiq) and ‘sage’ (ḥakīm) are examined and the literary culture fostered at the Ismaili fortresses, particularly Girdkūh, is explored. Significantly, the article draws attention to the position of Sanāʾī Ghaznawī (d.circa525/1131) in Persian Ismaili literature and to the very early development of pious, devotional and homiletic poetry as well as the “mathnawīmetre” in Ismaili environments, which may have helped set the stage for some of the most significant poetic achievements of mystical Islam: the writings of Farīd al-Dīn ʿAṭṭār (d.circa618/1221) and Jalāl al-Dīn Rūmī (d. 672/1273).
Functional Imaging of Neurotransmitters in Hymenolepis diminuta Treated with Senna Plant Through Light and Confocal Microscopy
Authors: Ukil Bidisha , Kundu Suman , Lyndem Larisha Mawkhlieng
Published: November 2018

Previous studies have shown the anthelmintic efficacy of Senna alata, Senna alexandrina and Senna occidentalis on the zoonotic parasite Hymenolepis diminuta through microscopic studies on morphological structure. The present study is based on the light and confocal microscopic studies to understand if Senna extracts affect neurotransmitter activity of the parasites. A standard concentration (40 mg/mL) of the three leaf extracts and one set of 0.005 mg/mL concentration of the reference drug praziquantel were tested against the parasites, keeping another set of parasites in phosphate buffer saline as a control. Histochemical studies were carried out using acetylthiocholine iodide as the substrate and acetylcholinesterase as the marker enzyme for studying the expression of the neurotransmitter of the parasite and the staining intensity was observed under a light microscope. Immunohistochemical studies were carried out using anti serotonin primary antibody and fluorescence tagged secondary antibody and observed using confocal microscopy. Intensity of the stain decreases in treated parasites compared with the control which implies loss of activity of the neurotransmitters. These observations indicated that Senna have a strong anthelmintic effect on the parasite model and thus pose as a potential anthelmintic therapy.
The Psychological Profile of Church of England Male Archdeacons at the Beginning of the Twenty-first Century: Drawing on Psychological Type and Temperament Theory
Authors: Francis Leslie J. , Whinney Michael
Published: November 2018

Recent discussion and research has pointed to the changing functions of archdeacons within the Church of England as the role has become expanded to combine both the traditional statutory functions with flexible and visionary leadership skills within a changing church. This study draws on data collected in 2009 from 186 active and retired male archdeacons in order to assess the psychological profile established by that time. Compared with the psychological profile of 626 clergymen, male archdeacons were much more likely to prefer the SJ temperament (60 per cent compared with 31 per cent), a temperament ideally suited for effective administration of the statutory functions. As a consequence, preference for intuition was lower among male archdeacons (38 per cent compared with 62 per cent), as was preference for perceiving (9 per cent compared with 32 per cent), qualities core for flexibility and visionary leadership.
Violence against Women in Politics: A Rising Global Trend
Authors: Krook Mona Lena
Published: November 2018

Recent years have witnessed a troubling rise in reports of assault, intimidation, and abuse directed at politically active women. The United Nations General Assembly first called for zero tolerance for violence against female candidates and elected officials in Resolution 66/130 in 2011. In 2012, Bolivia became the first country in the world to criminalize political violence and harassment against women, in response to a more than decade-long campaign by locally elected women to document the numerous injuries and abuses they confronted. Resonating across the region, this development led the states-parties to the Inter-American Convention on the Prevention, Punishment and Eradication of Violence against Women to endorse a Declaration on Political Violence and Harassment against Women in 2015.
Tracking natural organic carbon in the River Clyde, UK, using glycerol dialkyl glycerol tetraethers
Authors: Lopes dos Santos Raquel A. , Vane Christopher H.
Published: November 2018

Surface sediments from a 100-km stretch of the River Clyde, UK, and its estuary were analysed for glycerol dialkyl glycerol tetraethers (GDGTs) to track the downstream changes in the source of organic matter (OM) and to evaluate the impact of urbanisation. Bacterial membrane lipids, named branched GDGTs (brGDGTs), produced in soils and rivers ranged from 1.6 to 58μgg−1 organic carbon (OC) and the isoprenoid GDGT crenarchaeol, mainly from marine archaea, ranged from 0.01 to 42μgg−1 OC. The highest brGDGT concentrations were in the upper river, in Glasgow city and in the outer estuary, suggesting higher soil-derived OM input. By contrast, crenarchaeol concentrations gradually increased from the tidal weir in Glasgow towards the sea. This spatial distribution of the tetraethers was reflected in the branched and isoprenoid tetraether (BIT) index, a proxy for soil versus marine carbon. The highest BIT values (1.0) occurred upstream, estuarine values ranged from 0.9 to 0.6 and the lowest values (0.4) were found in the outer estuary. An independent proxy for soil-derived OM, stable carbon isotope (δ13C) values, showed a comparable decrease in terrigenous OM contribution towards the sea, but was more variable compared to the BIT. Conversely, carbon/nitrogen (C/N) showed a constant trend, suggesting that it is not a reliable indicator of OM source in the Clyde. Neither BIT, δ13C nor C/N were able to reflect the input of urban effluents from Glasgow.
Controls on surface water quality in the River Clyde catchment, Scotland, UK, with particular reference to chromium and lead
Authors: Bearcock J. M. , Smedley P. L. , Fordyce F. M. , Everett P. A. , Ander E. L.
Published: November 2018

Three collated geochemical surveys of surface water in the Clyde catchment have established the spatial variability in water composition, primarily under baseflow conditions. The waters are broadly pH-neutral to alkaline (maximum pH 8.7) in the lowlands, but mildly acidic in uplands on the catchment periphery. Electrical conductance is relatively high in lowland streams (maximum 8320μgL–1), with lower values in the uplands. Dissolved chromium (Cr; <0.05–971μgL–1) and lead (Pb; <0.05–19.4μgL–1) are of importance due to recognised pollution sources within the catchment. High aqueous Cr concentrations (>5μgL–1) are recorded in urban areas associated with the disposal of alkaline industrial chromite ore processing residue. Under such conditions, Cr probably occurs as Cr(VI). Numerous relatively high Pb values occur in the upland and urban areas. These are likely to be associated with a combination of soil reactions, diffuse pollution and contamination from Pb mineralisation/mining. Pb has a stronger correlation with water pH than with stream sediment Pb content, suggesting that pH has a greater control on Pb mobility than host-rock Pb. Exceedances of water-quality standards are <1% for both Cr and Pb across the catchment. Absolute exceedances are more extreme for Cr than for Pb, highlighting the scale of the Cr pollution problem for urban surface water within the catchment.
Factors affecting Observers’ Accuracy when Assessing Credibility: The Effect of the Interaction between Media, Senders’ Competence and Veracity
Authors: Caso Letizia , Maricchiolo Fridanna , Livi Stefano , Vrij Aldert , Palena Nicola
Published: November 2018

The present experiment examined how the interaction between senders’ communicative competence, veracity and the medium through which judgments were made affected observers’ accuracy. Stimuli were obtained from a previous study. Observers (N = 220) judged the truthfulness of statements provided by a good truth teller, a good liar, a bad truth teller, and a bad liar presented either via an audio-only, video-only, audio-video, or transcript format. Log-linear analyses showed that the data were best explained via the saturated model, therefore indicating that all the four variables interacted, G2(0) = 0, p = 1, Q2 = 1. Follow-up analyses showed that the good liar and bad liar were best evaluated via the transcript (z = 2.5) and the audio-only medium (z = 3.9), respectively. Both the good truth teller and the bad truth teller were best assessed through the audio-video medium (z = 2.1, good truth teller, z = 3.4, bad truth teller). Results indicated that all the factors interacted and played a joint role on observers’ accuracy. Difficulties and suggestions for choosing the right medium are presented.
Potential mechanisms for the effects of far-infrared on the cardiovascular system – a review
Authors: Shemilt Richard , Bagabir Hala , Lang Chim , Khan Faisel
Published: November 2018

Abstract. Far-infrared (FIR) is a form of thermal radiation, which may have beneficial effects on cardiovascular health. Clinical studies suggest that FIR irradiation may have therapeutic effects in heart failure, myocardial ischaemia and may improve flow and survival of arteriovenous fistula. Animal studies have suggested a wide range of potential mechanisms involving endothelial nitric oxide synthase and nitric oxide bioavailability, oxidative stress, heat shock proteins and endothelial precursor cells. However, the exact cellular and molecular mechanism of FIR on the cardiovascular system remains elusive. The purpose of this review is to discuss the current literature, focusing on mechanistic studies involving the cardiovascular system, and with a view to highlighting areas for future investigation.
Atacama Desert’s Unprecedented Rains Are Lethal to Microbes
Authors: Kornei Katherine
Published: November 2018

Rainfall in the driest parts of Chile’s Atacama Desert in 2017 resulted in hypersaline lagoons that killed the majority of microbes adapted to millions of years of arid conditions.
The Influence of Interannual Climate Variability on Regional Violent Crime Rates in the United States
Authors: Harp Ryan D. , Karnauskas Kristopher B.
Published: November 2018

While the impact of climate on regional geopolitical stability and large‐scale conflict has garnered increased visibility in recent years, the effects of climate variability on interpersonal violent crime have received only limited scientific attention. Though earlier studies have established a modest correlation between temperature and violent crime, the underlying seasonality in both variables was often not controlled for and spatial heterogeneity of the statistical relationships has largely been overlooked. Here a method of spatial aggregation is applied to the United States, enabling a systematic investigation into the observed relationships between large‐scale climate variability and regionally aggregated crime rates. This novel approach allows for differentiation between the effects of two previously proposed mechanisms linking climate and violent crime, the Routine Activities Theory and Temperature‐Aggression Hypothesis. Results indicate large and statistically significant positive correlations between the interannual variability of wintertime air temperature and both violent and property crime rates, with negligible correlations emerging from summertime data. Results strongly support the Routine Activities Theory linking climate and violent crime, with climate variability explaining well over a third of the variance of wintertime violent crime in several broad regions of the United States. Finally, results motivate the development of observationally constrained empirical models and their potential application to seasonal and potentially longer‐term forecasts.
Dynamical Drivers of the Local Wind Regime in a Himalayan Valley
Authors: Potter Emily R. , Orr Andrew , Willis Ian C. , Bannister Daniel , Salerno Franco
Published: November 2018

Understanding the local valley wind regimes in the Hindu‐Kush Karakoram Himalaya is vital for future predictions of the glacio‐hydro‐meteorological system. Here the Weather Research and Forecasting model is employed at a resolution of 1 km to investigate the forces driving the local valley wind regime in a river basin in the Nepalese Himalaya, during July 2013 and January 2014. Comparing with observations shows that the model represents the diurnal cycle of the winds well, with strong daytime up‐valley winds and weak nighttime winds in both months. A momentum budget analysis of the model output shows that in the summer run the physical drivers of the near‐surface valley wind also have a clear diurnal cycle, and are dominated by the pressure gradient, advection, and turbulent vertical mixing, as well as a nonphysical numerical diffusion term. By contrast, the drivers in the winter run have a less consistent diurnal cycle. In both months, the pressure gradient, advection, numerical diffusion, and Coriolis terms dominate up to 5,000 m above the ground. The drivers are extremely variable over the valley, and also influenced by the presence of glaciers. When glaciers are removed from the model in the summer run, the wind continues further up the valley, indicating how the local valley winds might respond to future glacier shrinkage. The spatial variability of the drivers over both months is consistent with the complex topography in the basin, which must therefore be well represented in weather and regional climate models to generate accurate outputs.
Generalised muscle weakness after bladder wall injection of Abobotulinum Toxin A: experience of a woman with tetraplegia who required increased caregiver support: importance of doctor–patient communication: duty of candour for spinal cord physician and responsibilities of a patient
Authors: Vaidyanathan Subramanian , Foster Tracey , Soni Bakul M.
Published: November 2018

Introduction

Generalised muscle weakness can occur after bladder wall injection of Abobotulinum toxin and the patient may require additional caregiver support.

Case presentation

A woman with C-8 AIS A tetraplegia received bladder wall injection of Abobotulinum toxin A 1000 units for detrusor over-activity. After 2.5 weeks, she developed weakness of arms; could not lift herself for pressure relief; could not transfer using sliding board; she regained the original muscle strength in 6 weeks. After 13 months, Abobotulinum toxin A 1000 units were injected into detrusor. Ten days after the second Abobotulinum toxin A injection, she developed generalised muscle weakness. She had not regained full function in her arms and hands 8 months later.

Prior to bladder wall injection of Abobotulinum toxin A, this patient was not aware that she could develop muscle weakness albeit very rarely. Therefore, the patient made no association of the muscle weakness, which occurred after the first injection, to Abobotulinum toxin A. For this reason, she did not inform the clinicians that she developed weakness of upper limbs following Abobotulinum toxin A injection. As she was not informed of this side effect before the second bladder wall injection of Abobotulinum toxin A, she consented to undergo the repeat procedure and developed generalised muscle weakness.

Discussion

Patients should inform doctors the adverse effects of medical therapy so that future treatment is amended to ensure patient safety. Professional duty of candour states that doctors should discuss risks which occur often, those that are serious even if very unlikely, and those that are important to the patient.
Tamoxifen therapy in a murine model of myotubular myopathy
Authors: Maani Nika , Sabha Nesrin , Rezai Kamran , Ramani Arun , Groom Linda , Eltayeb Nadine , Mavandadnejad Faranak , Pang Andrea , Russo Giulia , Brudno Michael , Haucke Volker , Dirksen Robert T. , Dowling James J.
Published: November 2018

Myotubular myopathy (MTM) is a severe X-linked disease without existing therapies. Here, we show that tamoxifen ameliorates MTM-related histopathological and functional abnormalities in mice, and nearly doubles survival. The beneficial effects of tamoxifen are mediated primarily via estrogen receptor signaling, as demonstrated through in vitro studies and in vivo phenotypic rescue with estradiol. RNA sequencing and protein expression analyses revealed that rescue is mediated in part through post-transcriptional reduction of dynamin-2, a known MTM modifier. These findings demonstrate an unexpected ability of tamoxifen to improve the murine MTM phenotype, providing preclinical evidence to support clinical translation.
A chromosome-scale assembly of the sorghum genome using nanopore sequencing and optical mapping
Authors: Deschamps Stéphane , Zhang Yun , Llaca Victor , Ye Liang , Sanyal Abhijit , King Matthew , May Gregory , Lin Haining
Published: November 2018

Long-read sequencing technologies have greatly facilitated assemblies of large eukaryotic genomes. In this paper, Oxford Nanopore sequences generated on a MinION sequencer are combined with Bionano Genomics Direct Label and Stain (DLS) optical maps to generate a chromosome-scale de novo assembly of the repeat-rich Sorghum bicolor Tx430 genome. The final assembly consists of 29 scaffolds, encompassing in most cases entire chromosome arms. It has a scaffold N50 of 33.28 Mbps and covers 90% of the expected genome length. A sequence accuracy of 99.85% is obtained after aligning the assembly against Illumina Tx430 data and 99.6% of the 34,211 public gene models align to the assembly. Comparisons of Tx430 and BTx623 DLS maps against the public BTx623 v3.0.1 genome assembly suggest substantial discrepancies whose origin remains to be determined. In summary, this study demonstrates that informative assemblies of complex plant genomes can be generated by combining nanopore sequencing with DLS optical maps.
Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function
Authors: Wang Fangjie , Meng Meng , Mo Banghui , Yang Yao , Ji Yan , Huang Pei , Lai Wenjing , Pan Xiaodong , You Tingting , Luo Hongqin , Guan Xiao , Deng Yafei , Yuan Shunzong , Chu Jianhong , Namaka Michael , Hughes Tiffany , Ye Lilin , Yu Jianhua , Li Xiaohui , Deng Youcai
Published: November 2018

The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact underlying mechanisms remain unclear. Here, we show, via conditional deletion of Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 and mTORC2 promote NK cell maturation in a cooperative and non-redundant manner, mainly by controlling the expression of Tbx21 and Eomes. Intriguingly, mTORC1 and mTORC2 regulate cytolytic function in an opposing way, exhibiting promoting and inhibitory effects on the anti-tumor ability and metabolism, respectively. mTORC1 sustains mTORC2 activity by maintaining CD122-mediated IL-15 signaling, whereas mTORC2 represses mTORC1-modulated NK cell effector functions by restraining STAT5-mediated SLC7A5 expression. These positive and negative crosstalks between mTORC1 and mTORC2 signaling thus variegate the magnitudes and kinetics of NK cell activation, and help define a paradigm for the modulation of NK maturation and effector functions.
Effective removal of mercury from aqueous streams via electrochemical alloy formation on platinum
Authors: Tunsu Cristian , Wickman Björn
Published: November 2018

Retrieval of mercury from aqueous streams has significant environmental and societal importance due to its very high toxicity and mobility. We present here a method to retrieve mercury from aqueous feeds via electrochemical alloy formation on thin platinum films. This application is a green and effective alternative to traditional chemical decontamination techniques. Under applied potential, mercury ions in solution form a stable PtHg4alloy with platinum on the cathode. A 100 nanometres platinum film was fully converted to a 750 nanometres thick layer of PtHg4. The overall removal capacity is very high, > 88 g mercury per cm3. The electrodes can easily be regenerated after use. Efficient and selective decontamination is possible in a wide pH range, allowing processing of industrial, municipal, and natural waters. The method is suited for both high and low concentrations of mercury and can reduce mercury levels far below the limits allowed in drinking water.