bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Large-scale Media on Online Marketing
Authors: Sun Ruibin
Published: January 2024

This study aims to explore the relationship between large-scale media (referring to individuals or companies with a large number of followers on social media) and marketing, and to utilize the influence of large-scale media to increase product sales and brand exposure. Specifically, the paper first introduces the concept of centrality, including degree centrality, closeness centrality, and betweenness centrality, as well as their applications in social networks. Then, this study regards large-scale media as nodes in the social network and proposes the centrality concept of large-scale media. Next, this study analyzes the influence and propagation effects of large-scale media in the social network, thereby highlighting the importance of large-scale media in marketing activities. Finally, through empirical analysis, the paper verifies the positive impact of the centrality of large-scale media on product sales and brand exposure. The findings of this study suggest that marketing professionals need to pay more attention to the role and value of large-scale media, and strengthen cooperation with large-scale media in marketing strategies. At the same time, this study proposes suggestions for optimizing marketing strategies using centrality methods, such as finding and cooperating with large-scale media with greater influence, and establishing a relationship network with central nodes. These suggestions can help improve product sales and brand exposure, thus bringing better business benefits to enterprises.
The Main Mechanisms and Characteristics of the Impart of Social Network on Consumer Behavior
Authors: Huang Nishan
Published: January 2024

Based on the contemporary social network environment, this paper discusses the practical significance of its impact on consumer behavior, and influencers as the main component of social network, this paper mainly take the mega-influencers and small influencers as the research object, through the analysis of the characteristics and application of the small-world network social network model to the micro-influencers, it is concluded that the influence of the mega- influencers on consumer decision-making is very important, but micro-influencers also play a subtle role in consumer behavior, which can be perceived as inseparable. At the same time, the application of small-world network model in economic management is a relatively new research field, which brings new ideas for economic management research and provides an effective technical tool. For example, this paper studies a new model of marketing through small-world network community, and innovates marketing strategy from two aspects of dominance and suggestion according to the different characteristics of mega-influencers and micro-influencers.
Digital Transformation of Supply Chain Management in the Fast Fashion Industry: A Case Study of Zara
Authors: Li Ruojia , Liu Wenxin , Zhou Sunwen
Published: January 2024

With continuous innovation and evolution in the clothing industry, fast fashion brands have gained significant popularity due to their ability to quickly respond to changing fashion trends, offer affordable and stylish clothing, and cater to the preferences of fashion-conscious consumers worldwide. This research analyzes the supply chain of the renowned fast fashion brand Zara, known for its unique supply chain management model. It is one of the most valuable apparel brands globally. The study explores the impact of supply chain management and digitalization on the entire fast fashion supply chain, encompassing upstream suppliers and manufacturers, middle-channel retailers and distributors, and consumers. Through a comprehensive examination of Zara’s success story, this study serves as an inspiring example for domestic apparel enterprises, showcasing the potential benefits that can arise from adopting a unique supply chain model, and offers valuable insights for Chinese apparel companies seeking to enhance their supply chain management and adapt to the digital era.
Building Information Modeling Digital Technology: The detail practice of BIM technology used in Environmental design teaching in High Educational Institution
Authors: Su Yang , Zhou Wei , Chen Yangzi , Huang Fang
Published: January 2024

Building Information Modelling(BIM) is the foundation of digital transformation in architecture, engineering, and construction(AEC)industry. BIM is the holistic process of creating and managing information for a built asset. A traditional CAD and 3D modelling technology is widely used in university’s architecture and landscape courses teaching today. Every single detail of traditional course education does not match the internationally market and BIM technology which is more common and popular today. Using BIM technology in university to teach architecture and landscape design will make changes to design education, and will improve the education practice in Environmental Design system. This article will introduce more detail about BIM technology, and how it changes and affects traditional architecture & landscape teaching, how this technology merged with professions, and how this technology brings comprehensive learning ways and new insight for students in their future career life.
Research on the Cultivation of Business English Talents for the Regional Digital Economic Development
Authors: Shi Ling
Published: January 2024

With the rapid development of the digital economy, the demand for language talents has increased significantly, especially for Business English majors. However, the traditional talent cultivation model has failed to keep up with the needs of regional digital economic development. This research aims to explore a suitable path for cultivating language talents to empower regional digital economic development through language services. Firstly, the current state of regional digital economic development and the demand for language talents are analysed. It is found that there is a mismatch between talent supply and demand, which hinders the development of regional digital economic industries. Next, the research reviews the existing talent cultivation models and identifies their limitations. The traditional language education focuses on language proficiency without addressing the specific needs of the digital economy. Lastly, the research provides suggestions for improving the talent cultivation system, including curriculum reform, industry-academia collaboration, and internships in language service companies. The research proposes an innovative cultivation path for business English talents, which combines language proficiency, digital skills, and industry-specific knowledge, aiming to meet the needs of the rapidly evolving digital economy.
Transformation in Organizational and Human Resource Management in the Digital Intelligence Age
Authors: Yang Zhengyu
Published: January 2024

This article explores the revolutionary impact of digital technology and artificial intelligence on organizational and human resource management in the era of digital intelligence. Confronted with challenges in industrial evolution, technological innovation, and customer-centric dynamics, businesses are urged to embrace innovation and instill a culture of transformation. The pivotal focus lies in propelling the transformation of organizational and human resource management in six key dimensions. Firstly, organizational systems evolve to become more open, interconnected, flexible, and adaptive. Secondly, human resource allocation diversifies, emphasizing collaborative synergy among team members. Thirdly, performance management methods underscore alignment with organizational strategy and culture, emphasizing the improvement of employees’ perspective and competence. Fourthly, values management signifies a shift towards intrinsic motivation and cultural consistency in personnel management. Fifthly, leadership styles stress motivation, empowerment, and support, prioritizing an employee-centric approach. Sixthly, it underscores the value of human capital as the cornerstone of innovative incentive strategies, advocating for sustained investment in key talent. In summary, the framework advocates for innovation as a strategic imperative, recognizing the intrinsic value of individuals as the driving force behind organizational success and underscoring human resources as a pivotal driver of organizational development in the era of digital intelligence.
Digital technology and the revival of Chinese excellent traditional culture
Authors: Yu Xinyi
Published: January 2024

Chinese excellent traditional culture is the spiritual bloodline and unique spiritual identity inherited by the Chinese nation, with the continuous development of information technology, digital technology is becoming more and more mature, the development of digital dissemination of culture and art has now gathered a variety of energy, digital technology has become one of the important areas in the development of Chinese excellent traditional culture and art. The creation of digital technology and the development of traditional culture and art are bound to produce some collision, so how to find a balance between the two, and the two mutual achievement, is a problem worth exploring. In this paper, we will discuss the symbiotic relationship between digital technology and the revival of Chinese outstanding traditional culture from several perspectives, including the regeneration of Chinese outstanding traditional art, the protection of intangible cultural heritage, and the display of digitized collections in Chinese cultural venues, as well as by combining important cases.
Digital innovation ecosystem and innovation of SMEs: A case study of Anker
Authors: Gao Shuai
Published: January 2024

Digital technology has changed the original product form, the way of new product production process, business model and organizational form, and even overturned the basic assumptions of many innovation theories. Embedding digital innovation ecosystem makes it possible for small and medium-sized manufacturing enterprises to create value from the production side in the industrial era to the demand side in the digital economy era. Through a typical vertical case analysis, this paper reveals the internal mechanism and process of digital innovation ecosystem enpowers the innovation of small and medium-sized manufacturing enterprises. The research results show that the embedding of digital innovation ecosystem has a significant positive impact on the innovation performance of small and medium-sized manufacturing enterprises, and value co-creation plays an intermediary role between digital innovation ecosystem and the innovation performance of small and medium-sized manufacturing enterprises. This paper puts forward the innovation theoretical framework of small and medium-sized manufacturing enterprises from the perspective of digital innovation ecosystem.
The application of abstract think and graphic language for diagrammatic thinking in space design
Authors: Chen Yangzi
Published: January 2024

Environmental design as a practical major in the university, is concentrating on training students to become professional designers to fit the requirements of the design market today. Traditional design education that only construction documents with CAD technology training has no longer satisfied the needs of economy and the market today, so we have to explore new strategy to change the way of teaching. This article explores some examples of new strategy of how to set up lecture, studio practices, and competition workshop for environmental design course system in high education institute in China. The goal is to transform abstractive thinking in art and design perception to representational diagram in visual technique. We hope this new exploration can reform the atmosphere during studio education, with merging new technique such as new digital media, AI and IT technology, and therefore, change the learning technique and improve students to learn more.
A Study on the Compatibility between the Digital Reform of Agricultural Insurance and the Needs of Farmers: A Case Study of Ningbo City, Zhejiang Province
Authors: Zhang Qingyi , Luo Jingyu
Published: January 2024

Agricultural insurance of China has covered all fields of agriculture, including forestry, animal husbandry and fishery. Although great progress has been made in the digital reform of agricultural insurance, the degree of digitalization of agricultural insurance is still slow. Farmers’ understanding and participation in agricultural insurance is the important consideration of promoting digital degree of agricultural insurance in Zhejiang Province. Focusing on the supply-side reform, the digital reform of agricultural insurance also needs to consider the situation of the demand-side of farmers, promote traditional agriculture to have been transformed from “relying on the weather” to “working with the weather”.
Deposition of ultrathick heavy-metal alloys on rotating substrates by high-power impulse magnetron sputtering: Target erosion effects
Authors: Shin S. J. , Bae J. H. , Engwall A. M. , Bayu Aji L. B. , Baker A. A. , Taylor G. V. , Merlo J. B. , Sohngen L. R. , Moody J. D. , Kucheyev S. O.
Published: January 2024

Sputter deposition of ultrathick (≈20μm) Au–Ta alloy coatings on sphero-cylindrical substrates is key for the fabrication of hohlraums for magnetically assisted inertial confinement fusion. Here, we study the deposition of AuTa4 alloy coatings onto rotating substrates. We use high-power impulse magnetron sputtering (HiPIMS) in a constant peak target voltage mode. Results show that the target erosion state has a strong impact on the dominant crystallographic phase, microstructure, surface morphology, and electrical resistivity of AuTa4 films. This is due to effects of changes in the confining magnetic field with target erosion on the HiPIMS discharge characteristics and the sputter source output. We quantify these effects via plasma diagnostics and discuss the optimization of HiPIMS deposition of ultrathick films for cases when target erosion effects dominate film properties.
Model-free characterization of topological edge and corner states in mechanical networks
Authors: Guzman Marcelo , Guo Xiaofei , Coulais Corentin , Carpentier David , Bartolo Denis
Published: January 2024

Topological materials can host edge and corner states that are protected from disorder and material imperfections. In particular, the topological edge states of mechanical structures present unmatched opportunities for achieving robust responses in wave guiding, sensing, computation, and filtering. However, determining whether a mechanical structure is topologically nontrivial and features topologically protected modes has hitherto relied on theoretical models. This strong requirement has limited the experimental and practical significance of topological mechanics to laboratory demonstrations. Here, we introduce and validate an experimental method to detect the topologically protected zero modes of mechanical structures without resorting to any modeling step. Our practical method is based on a simple electrostatic analogy: Topological zero modes are akin to electric charges. To detect them, we identify elementary mechanical molecules and measure their chiral polarization, a recently introduced marker of topology in chiral phases. Topological zero modes are then identified as singularities of the polarization field. Our method readily applies to any mechanical structure and effectively detects the edge and corner states of regular and higher-order topological insulators. Our findings extend the reach of chiral topological phases beyond designer materials and allow their direct experimental investigation.
Interfacial solvation-structure regulation for stable Li metal anode by a desolvation coating technique
Authors: Li Guo-Xing , Lennartz Peter , Koverga Volodymyr , Kou Rong , Nguyen Au , Jiang Heng , Liao Meng , Wang Daiwei , Dandu Naveen , Zepeda Michael , Wang Haiying , Wang Ke , Ngo Anh T. , Brunklaus Gunther , Wang Donghai
Published: January 2024

Rechargeable lithium (Li) metal batteries face challenges in achieving stable cycling due to the instability of the solid electrolyte interphase (SEI). The Li-ion solvation structure and its desolvation process are crucial for the formation of a stable SEI on Li metal anodes and improving Li plating/stripping kinetics. This research introduces an interfacial desolvation coating technique to actively modulate the Li-ion solvation structure at the Li metal interface and regulate the participation of the electrolyte solvent in SEI formation. Through experimental investigations conducted using a carbonate electrolyte with limited compatibility to Li metal, the optimized desolvation coating layer, composed of 12-crown-4 ether-modified silica materials, selectively displaces strongly coordinating solvents while simultaneously enriching weakly coordinating fluorinated solvents at the Li metal/electrolyte interface. This selective desolvation and enrichment effect reduce solvent participation to SEI and thus facilitate the formation of a LiF-dominant SEI with greatly reduced organic species on the Li metal surface, as conclusively verified through various characterization techniques including XPS, quantitative NMR, operando NMR, cryo-TEM, EELS, and EDS. The interfacial desolvation coating technique enables excellent rate cycling stability (i.e., 1C) of the Li metal anode and prolonged cycling life of the Li||LiCoO
2
pouch cell in the conventional carbonate electrolyte (E/C 2.6 g/Ah), with 80% capacity retention after 333 cycles.
Design of blasting patterns to induce effective caving in continuous miner depillaring panel – a case study
Authors: Pal Roy Pijush , Sawmliana Chhangte , Singh Rakesh Kumar
Published: January 2024

An innovative scheme of induced caving by blasting was adopted in the depillaring continuous miner panel CM1 of Jhanjra Colliery of Eastern Coalfields Limited, a subsidiary of Coal India Limited. Initially, the blasting pattern was designed with respect to underground workings and later with respect to the surface, vertically above the panel, to facilitate effective caving. The natural caving was delayed due to the presence of three hard-rock beds of more than 5000 cavability index in the immediate roof of the R-VI seam in addition to the oversized left-out standing pillars kept during coal extraction in the panel, which provided extra supports to the hanging roof-rock in the goaf. To mitigate the situation, the design parameters were meticulously planned and implemented for successful blasting operations, which led to effective caving in the goaf and enabled successful extraction of the coal from the panel maintaining the required level of safety and productivity.
Effect of temperature variation on the behaviour of Bushveld rocks: comparison of laboratory test and numerical modelling results
Authors: Oniyide G. O. , Yilmaz H. , Nordlund E.
Published: January 2024

This paper presents the result of the research carried out on the effect of temperature on the Bushveld Igneous Complex (BIC), South Africa. The BIC has high virgin rock temperature. If the platinum mines advance to ultra-deep levels, then the virgin rock temperature at a depth of 5 km will be approximately 140°C. Hence, there is a need to improve the understanding of the behaviour of rock under high temperatures. Five rock types were tested in a 2600 kN servo-controlled testing machine. The testing was done at a controlled loading rate and a confining pressure 0, 10, and 30 MPa within temperature range of 20–140°C. Comparison was made between the results obtained from the laboratory experiments and numerical modelling. It was observed from the stress–strain behaviour of the samples that an increase in temperature results in the reduction of the Young's modulus and peak strength.
Rib scaling and the stability of coal pillars
Authors: Seedsman Ross
Published: January 2024

The prediction of the depth of fracturing in the sides of underground excavations in coal seams is needed to determine the requirements for rib support and to assess pillar stability. The prediction requires consideration of how coal strength is determined and extrapolated to the mine scale and how stresses are redistributed around excavations in bedded coal masses. The impact of bedding in a stress analysis can be examined by adopting transverse isotropy and this results in much lower confining stresses in the horizontal plane and much higher vertical stresses close to the excavation boundary. The extent of rib scaling can be derived if the bedded coal is modelled as a brittle material. For coal pillars, the depth of scaling may be sufficient to have a material impact on their effective width and hence stability. The specification of rib support needs to consider how the failed coal may subsequently collapse.
Establishing the quantitative and qualitative limits of the applicability of the multi-stage dumping sequence in open pit mining
Authors: Kuckartz Bruno T. , Victoria Euler F. V. , Peroni R. L.
Published: January 2024

Environmental issues and sustainability are currently being discussed and studied in several areas of mining technology; combining these issues with improved mining operation and management is part of strategic mine planning. Waste management plays an important role in this process, as an alternative way of minimising environmental impacts and achieving more attractive economic scenarios, such as backfilling the pit. This study aimed to evaluate the application of the multi-stage dumping sequence (MSDS) in conjunction with in-pit deposition strategy for a phosphate mine providing general orientations and limits of applicability of the method. The MSDS makes use of temporary waste dumps which gives operational flexibility regarding waste management while reducing the Net Present Cost (NPC) (up to 8% in this study) compared with the traditional and sometimes untouchable rule of no re-handling approach during waste disposal.
On median filters for motion by mean curvature
Authors: Esedoḡlu Selim , Guo Jiajia , Li David
Published: January 2024

The median filter scheme is an elegant, monotone discretization of the level set formulation of motion by mean curvature. It turns out to evolve every level set of the initial condition precisely by another class of methods known as threshold dynamics. Median filters are, in other words, the natural level set versions of threshold dynamics algorithms. Exploiting this connection, we revisit median filters in light of recent progress on the threshold dynamics method. In particular, we give a variational formulation of, and exhibit a Lyapunov function for, median filters, resulting in energy based unconditional stability properties. The connection also yields analogues of median filters in the multiphase setting of mean curvature flow of networks. These new multiphase level set methods do not require frequent redistancing, and can accommodate a wide range of surface tensions.
Linear asymptotic stability of small-amplitude periodic waves of the generalized Korteweg–de Vries equations
Authors: Audiard Corentin , Rodrigues L. , Sun Changzhen
Published: January 2024

We extend the detailed study of the linearized dynamics obtained for cnoidal waves of the Korteweg–de Vries equation by Rodrigues [J. Funct. Anal. 274 (2018), pp. 2553–2605] to small-amplitude periodic traveling waves of the generalized Korteweg–de Vries equations that are not subject to Benjamin–Feir instability. With the adapted notion of stability, this provides for such waves, global-in-time bounded stability in any Sobolev space, and asymptotic stability of dispersive type. When doing so, we actually prove that such results also hold for waves of arbitrary amplitude satisfying a form of spectral stability designated here as dispersive spectral stability.
On Kigami’s conjecture of the embedding 𝒲^{𝓅}(𝒦)⊂𝒞(𝒦)
Authors: Cao Shiping , Chen Zhen-Qing , Kumagai Takashi
Published: January 2024

Let

(
K
,
d
)

(K,d)

be a connected compact metric space and

p
∈
(
1
,
∞
)

p\in (1, \infty )

. Under the assumption of Kigami [Conductive homogeneity of compact metric spaces and construction of p-energy, Memoirs of the European Mathematical Society, vol. 5, Europea Mathematical Society (EMS), Berline, 2023, Assumption 2.15] and the conductive

p
p

-homogeneity, we show that

W

p

(
K
)
⊂
C
(
K
)

\mathcal {W}^p(K)\subset C(K)

holds if and only if

p
>

dim

A
R

⁡
(
K
,
d
)

p>\operatorname {dim}_{AR}(K,d)

, where

W

p

(
K
)

\mathcal {W}^p(K)

is Kigami’s

(
1
,
p
)

(1,p)

-Sobolev space and

dim

A
R

⁡
(
K
,
d
)

\operatorname {dim}_{AR}(K,d)

is the Ahlfors regular dimension.
Identification of maximal C*-covers of some operator algebras
Authors: Duncan Benton
Published: January 2024

We use results on inclusions of free products and extensions of completely positive maps to determine the maximal C

∗

^*

-envelope for upper triangular

3
×
3

3 \times 3

matrices. We consider these same results in the context of larger upper triangular matrices and graph algebras associated to cycle graphs.
The infinitesimal deformations of hypersurfaces that preserve the Gauss map
Authors: Dajczer Marcos , Jimenez Miguel
Published: January 2024

Classifying the nonflat hypersurfaces in Euclidean space

f
:

M
n

→

R

n
+
1

f\colon M^n\to \mathbb {R}^{n+1}

that locally admit smooth infinitesimal deformations that preserve the Gauss map infinitesimally was a problem only considered by Schouten in 1928 [Proceedings Amsterdam 31 (1928), pp. 208–218]. He found two conditions that are necessary and sufficient, with the first one being the minimality of the submanifold. The second is a technical condition that does not clarify much about the geometric nature of the hypersurface. In that respect, the parametric solution of the problem given in this note yields that the submanifold has to be Kaehler.
YTHDF2-regulated matrilin-3 mitigates post-reperfusion hemorrhagic transformation in ischemic stroke via the PI3K/AKT pathway
Authors: Chen Hanze , Guo Siping , Li Runnan , Yang Lihui , Wang Rui , Jiang Yasi , Hao Yonggang
Published: January 2024

Hemorrhagic transformation can complicate ischemic strokes after recanalization treatment within a time window that requires early intervention. To determine potential therapeutic effects of matrilin-3, rat cerebral ischemia-reperfusion was produced using transient middle cerebral artery occlusion (tMCAO); intracranial hemorrhage and infarct volumes were assayed through hemoglobin determination and 2,3,5-triphenyltetrazoliumchloride (TTC) staining, respectively. Oxygen-glucose deprivation (OGD) modeling of ischemia was performed on C8-D1A cells. Interactions between matrilin-3 and YTH N6-methyladenosine RNA binding protein F2 (YTHDF2) were determined using RNA immunoprecipitation assay and actinomycin D treatment. Reperfusion after tMCAO modeling increased hemorrhage, hemoglobin content, and infarct volumes; these were alleviated by matrilin treatment. Matrilin-3 was expressed at low levels and YTHDF2 was expressed at high levels in ischemic brains. In OGD-induced cells, matrilin-3 was negatively regulated by YTHDF2. Matrilin-3 overexpression downregulated p-PI3K/PI3K, p-AKT/AKT, ZO-1, VE-cadherin and occludin, and upregulated p-JNK/JNK in ischemic rat brains; these effects were reversed by LY294002 (a PI3K inhibitor). YTHDF2 knockdown inactivated the PI3K/AKT pathway, inhibited inflammation and decreased blood-brain barrier-related protein levels in cells; these effects were reversed by matrilin-3 deficiency. These results indicate that YTHDF2-regulated matrilin-3 protected ischemic rats against post-reperfusion hemorrhagic transformation via the PI3K/AKT pathway and that matrilin may have therapeutic potential in ischemic stroke.
Sequential treatment escalation improves survival in patients with Waldenstrom macroglobulinemia
Authors: Yu Ying , Xiong Wenjie , Wang Tingyu , Yan Yuting , Lyu Rui , Wang Qi , Liu Wei , An Gang , Sui Weiwei , Xu Yan , Huang Wenyang , Zou Dehui , Wang Jianxiang , Qiu Lugui , Yi Shuhua
Published: January 2024

Waldenstrom macroglobulinemia (WM) is a type of incurable, indolent B-cell lymphoma that is prone to relapse. Over time, treatment strategies have progressed from cytotoxic drugs to rituximab (R)- or bortezomib (V)-based regimens, and have now entered into an era of Bruton tyrosine kinase inhibitor (BTKi)-based regimens. However, the optimal treatment for the relapsed patients is still unclear. Herein, we analyzed the outcomes of the first- and second-line therapies in 377 patients with WM to illustrate the optimal choices for second-line therapy. After a median follow-up of 45.4 months, 89 patients received second-line therapy, and 53 patients were evaluated for response. The major response rates (MRR) of first- and second-line treatment were 65.1% and 67.9% (P = 0.678). The median progression-free survival (PFS) for the second-line therapy (PFS2) was shorter than that for the first-line therapy (PFS1) (56.3 vs 40.7 months, P = 0.03). However, PFS2 in targeted drugs group (R-/V-/BTKi-based regimens) was comparable to PFS1 (60.7 months vs 44.7 months, respectively, P = 0.21). Regarding second-line therapy, patients who underwent sequential treatment escalation—such as transitioning from cytotoxic drugs to R-/V-/BTKi-based regimens or from R-/V-based to BTKi-based regimens (escalation group) —had higher MRR (80.6% vs 47.1%, respectively, P = 0.023) and longer PFS2 (50.4 vs 23.5 months, respectively, P < 0.001) compared to the non-escalation group. Patients in the escalation group also had longer post-relapse overall survival compared with the non-escalation group (median, not reached vs 50.7 months, respectively, P = 0.039). Our findings indicate that sequential treatment escalation may improve the survival of patients with WM.
Nivolumab in Squamous Cell Carcinomas of the Head and Neck (SCCHN): A Real-world Outcome Study in Ontario, Canada
Authors: Zereshkian Arman , Shafi Ruaa , Pond Gregory R. , Hotte Sebastien J.
Published: January 2024

The CheckMate-141 trial led to the approval of nivolumab in platinum-resistant metastatic/advanced squamous cell carcinomas of the head and neck (SCCHN). We evaluated the outcomes of SCCHN patients in Ontario, Canada, treated with nivolumab through retrospective review of the provincial treatment registry. Kaplan-Meier method was used to estimate overall survival (OS) and Cox regression to evaluate the prognostic effect of selected factors. Nivolumab was used as second-line therapy after disease relapse for curative-intent platinum chemotherapy (PC) (indication 1–I1), as second-line therapy post-PC in noncurative intent (indication 2–I2), and as first-line therapy in noncurative intent due to contraindication for PC (indication 3–I3). The median OS for patients treated with nivolumab was 5.8 months (95% CI: 4.5–7.3), and the 1-year OS was 28.4% (CI: 2.10–36.1). When patients with I3 were excluded to match inclusion criteria for CheckMate-141, median OS was 4.8 months (CI: 3.6–6.7) with 1-year OS of 21.8% (14.4–30.1). Patients with lower body surface area (BSA) (<1.81) had a median OS of 3.9 months (CI: 3.1–6.7) versus 9.0 months (CI: 6.5–14.8) in those with higher BSA, hazard ratio (HR)=0.12 (CI: 0.04–0.39, P<0.001). Patients receiving nivolumab for I1 had a median OS of 7.2 months (CI 3.8–9.8) versus 11.9 months (CI: 6.2-not reached) for I3, HR=1.73 (CI: 0.94–3.16). Patients receiving nivolumab for I2 had a median OS of 3.9 months (CI: 2.9–5.4) as compared with I3, HR=3.27 (CI: 1.80–5.94). Real-world analysis of patients with advanced/metastatic SCCHN in Ontario, Canada, treated with nivolumab demonstrates poorer median OS compared with CheckMate-141 trial. Lower BSA was a predictor of poorer median OS.
Association of sleep quality on the night of operative day with postoperative delirium in elderly patients
Authors: Ou-yang Chun-lei , Ma Li-bin , Wu Xiao-dong , Ma Yu-long , Liu Yan-hong , Tong Li , Li Hao , Lou Jing-sheng , Cao Jiang-bei , Mi Wei-dong
Published: January 2024

BACKGROUND

Sleep disturbances in the peri-operative period have been associated with adverse outcomes, including postoperative delirium (POD). However, research on sleep quality during the immediate postoperative period is limited.

OBJECTIVES

This study aimed to investigate the association between sleep quality on the night of the operative day assessed using the Sleep Quality Numeric Rating Scale (SQ-NRS), and the incidence of POD in a large cohort of surgical patients.

DESIGN

A prospective cohort study.

SETTING

A tertiary hospital in China.

PATIENTS

This study enrolled patients aged 65 years or older undergoing elective surgery under general anaesthesia. The participants were categorised into the sleep disturbance and no sleep disturbance groups according to their operative night SQ-NRS.

MAIN OUTCOME MEASURES

The primary outcome was delirium incidence, whereas the secondary outcomes included acute kidney injury, stroke, pulmonary infection, cardiovascular complications and all-cause mortality within 1 year postoperatively.

RESULTS

In total, 3072 patients were included in the analysis of this study. Among them, 791 (25.72%) experienced sleep disturbances on the night of operative day. Patients in the sleep disturbance group had a significantly higher risk of developing POD (adjusted OR 1.43, 95% CI 1.11 to 1.82, P = 0.005). Subgroup analysis revealed that age 65–75 years; male sex; ASA III and IV; haemoglobin more than 12 g l−1; intra-operative hypotension; surgical duration more than 120 min; and education 9 years or less were significantly associated with POD. No interaction was observed between the subgroups. No significant differences were observed in the secondary outcomes, such as acute kidney injury, stroke, pulmonary infection, cardiovascular complications and all-cause mortality within 1 year postoperatively.

CONCLUSIONS

The poor subjective sleep quality on the night of operative day was independently associated with increased POD risk, especially in certain subpopulations. Optimising peri-operative sleep may reduce POD. Further research should investigate potential mechanisms and causal relationships.

TRIAL REGISTRY

chictr.org.cn: ChiCTR1900028545.
Blood pressure lowering for kidney transplant recipients: systematic review with network meta-analysis
Authors: Natale Patrizia , Palmer Suetonia C. , Jaure Allison , Saglimbene Valeria , Iannone Andrea , Sluiter Amanda , Craig Jonathan , Strippoli Giovanni F.M.
Published: January 2024

Objective:

Hypertension affects 50–90% of kidney transplant recipients and is associated with cardiovascular disease and graft loss. We aimed to evaluate the comparative benefits and harms of blood pressure lowering agents in people with a functioning kidney transplant.

Methods:

We conducted a systematic review with network meta-analysis of randomized controlled trials (RCTs). We searched MEDLINE, Embase, and CENTRAL through to October 2023. RCTs evaluating blood pressure lowering agents administered for at least 2 weeks in people with a functioning kidney transplant with and without preexisting hypertension were eligible. Two reviewers independently extracted data. The primary outcome was graft loss. Treatment effects were estimated using random effects network meta-analysis, with treatment effects expressed as an odds ratio (OR) for binary outcomes and mean difference (MD) for continuous outcomes together with their 95% confidence interval (CI). Confidence in the evidence was assessed using GRADE for network meta-analysis.

Results:

Ninety-four studies (7547 adults) were included. Two studies were conducted in children. No blood pressure-lowering agent reduced the risk of graft loss, withdrawal because of adverse events, death, cardiovascular or kidney outcomes compared with placebo/other drug class. Angiotensin-converting enzyme inhibitors and angiotensin receptor blocker therapy may incur greater odds of hyperkalemia compared with calcium channel blockers [odds ratio (OR) 5.48, 95% confidence interval (CI) 2.47–12.16; and OR 8.67, 95% CI 2.65–28.36; low certainty evidence, respectively).

Conclusion:

The evidentiary basis for the comparative benefits and safety of blood pressure lowering agents in people with a functioning kidney transplant is limited to guide treatment decision-making.
Skin and Bone: Intact Fish Skin to Reconstruct Traumatic Orbital Floor and Wall Defects
Authors: Steinberger Elise E. , Vogt Ashtyn Z. , Tan Jeremy F.
Published: January 2024

Orbital reconstruction following orbital trauma, tissue sacrifice from cancer resection, or other tissue loss poses a unique challenge for surgeons. Factors to consider include the patient’s systemic health status, potential for adjuvant radiation, final composition, and strength of the graft, infection risk, graft rejection, status of visual function, and cosmetic outcome. In settings where a permanent artificial implant is avoided due to exposure or infection risk, potential tissue utilized includes xenografts, allografts, and autografts—each with variable benefits and drawbacks, depending on the surgical goals of the repair. We describe a case of orbital reconstruction after a gunshot wound to the left orbit using tri-layer Kerecis (decellularized intact North-Atlantic cod fish skin) with excellent globe position and maintenance of ocular motility.
Listeria innocua infection in an old case of total knee replacement – an unusual case report
Authors: Gupta Minakshi , Saha Uma Shankar , Kumar Ritesh , Laik Jayanta , Mishra Minakshi
Published: January 2024

Prosthetic implant-associated arthritis due to

Listeria

is mostly reported for

Listeria monocytogenes

. Here, we describe a patient who underwent total knee replacement 12 years ago and presented with pain, tenderness, redness and local rise in temperature in the right knee. Purulent fluid was aspirated. Upon microbiological analysis, culture yielded

Listeria innocua

.

L. innocua

is rare.

Listeria

is not reported as a contaminant and routine cultures may be negative. Because of the long interval between surgery and the onset of symptoms, clinical suspicion, radiological investigations and analysing multiple samples are of immense help.
Complete genome sequence of a winter season Vibrio facilitates discovery of a novel subclade of cold-adapted species in the albus clade
Authors: Kastner Paul D. , Noell Stephen E. , Essig David A.
Published: January 2024

In temperate marine climate zones, seasonal changes in water temperature contribute to distinct populations of warm- and cold-water vibrios. We report here the complete genome sequence (BUSCO score=94.8) of the novel strain

Vibrio

sp. VB16 isolated in late winter from the intertidal zone near Virginia Beach, Virginia, USA with the ability to form colonies at 4 °C. The 5.2 Mbp genome is composed of a large (3.6 Mbp) and small (1.6 Mbp) chromosome. Based on paired average nucleotide identity (ANI), average amino acid identity (AAI) and digital DNA–DNA hybridization (dDDH), V. sp. VB16 is the same species as V. sp. UBA2437 from a North Sea tidal flat and is closely related to V. sp. DW001 from Antarctic sea ice. Our phylogenomic and bioinformatic analyses placed VB16, UBA2437 and DW001 into a cold-tolerant subclade within the albus clade, along with two non-cold-tolerant subclades. Orthovenn analysis indicated that VB16 and its other albus clade members shared 1544 gene orthologue clusters, including clusters for biosynthesis of polar flagella and tight adhesion pili that predict multiple lifestyles, either free-living or as an opportunistic pathogen within a marine eukaryotic host. The cold-tolerant subclade shared 552 orthologue proteins, including genes known to promote survival in cold or freezing temperatures, such as the eicosapentaenoic acid biosynthetic gene cluster, syp exopolysaccharide gene cluster and novel giant proteins with ice-binding domains. This subclade represents a group of psychrotolerant or ‘moderate psychrophile’ winter season

Vibrio

species. The discovery of this subclade opens the door for experimental work on the physiological features, virulence potential and ecological importance of this subclade.
Effect of sword bean (Canavalia ensiformis)
fermentation filtrate on the antioxidant, anti-inflammatory, and
antimicrobial activities
Authors: Jang Hye-Lim
Published: January 2024

In the present study, various experiments were performed to evaluate the
biological activities, such as the antioxidant, anti-inflammation, and
antimicrobial activities of sword bean (Canavalia ensiformis)
fermentation filtrate by Lactobacillus plantarum (L.
plantarum) and Lactobacillus brevis (L.
brevis). Total polyphenol (TPC) and flavonoid contents (TFC) of
sword bean were significantly decreased after fermentation regardless of
Lactobacillus sp. (p<0.05). The DPPH radical
scavenging activity of sword beans also decreased after fermentation. However,
nitric oxide (NO) radical scavenging activity conspicuous increased after
fermentation (p<0.001) in a treated concentration-dependent manner, and
the effect for L. brevis was higher than for L.
plantarum. In addition, the sword bean fermentation filtrate showed
a strong inhibitory effect against Pseudomonas aeruginosa,
Staphylococcus sp., and Escherichia coli.
Cell cytotoxicity was not exhibited in all experimental groups (data not shown).
These findings suggest that the sword bean fermentation filtrate may be used
effectively in various industries due to its high anti-inflammatory and
antimicrobial activities.
Theory of percolation on hypergraphs
Authors: Bianconi Ginestra , Dorogovtsev Sergey N.
Published: January 2024

Hypergraphs capture the higher-order interactions in complex systems and always admit a factor graph representation, consisting of a bipartite network of nodes and hyperedges. As hypegraphs are ubiquitous, investigating hypergraph robustness is a problem of major research interest. In the literature the robustness of hypergraphs so far only has been treated adopting factor-graph percolation, which describes well higher-order interactions which remain functional even after the removal of one of more of their nodes. This approach, however, fall short to describe situations in which higher-order interactions fail when any one of their nodes is removed, this latter scenario applying, for instance, to supply chains, catalytic networks, protein-interaction networks, networks of chemical reactions, etc. Here we show that in these cases the correct process to investigate is hypergraph percolation, with is distinct from factor graph percolation. We build a message-passing theory of hypergraph percolation, and we investigate its critical behavior using generating function formalism supported by Monte Carlo simulations on random graph and real data. Notably, we show that the node percolation threshold on hypergraphs exceeds node percolation threshold on factor graphs. Furthermore we show that differently from what happens in ordinary graphs, on hypergraphs the node percolation threshold and hyperedge percolation threshold do not coincide, with the node percolation threshold exceeding the hyperedge percolation threshold. These results demonstrate that any fat-tailed cardinality distribution of hyperedges cannot lead to the hyper-resilience phenomenon in hypergraphs in contrast to their factor graphs, where the divergent second moment of a cardinality distribution guarantees zero percolation threshold.

Published by the American Physical Society
2024
Nature of hypergraph
k
-core percolation problems
Authors: Bianconi Ginestra , Dorogovtsev Sergey N.
Published: January 2024

Hypergraphs are higher-order networks that capture the interactions between two or more nodes. Hypergraphs can always be represented by factor graphs, i.e., bipartite networks between nodes and factor nodes (representing groups of nodes). Despite this universal representation, here we reveal that k-core percolation on hypergraphs can be significantly distinct from k-core percolation on factor graphs. We formulate the theory of hypergraph k-core percolation based on the assumption that a hyperedge can be intact only if all its nodes are intact. This scenario applies, for instance, to supply chains where the production of a product requires all raw materials and all processing steps; in biology it applies to protein-interaction networks where protein complexes can function only if all the proteins are present; and it applies as well to chemical reaction networks where a chemical reaction can take place only when all the reactants are present. Formulating a message-passing theory for hypergraph k-core percolation, and combining it with the theory of critical phenomena on networks, we demonstrate sharp differences with previously studied factor graph k-core percolation processes where it is allowed for hyperedges to have one or more damaged nodes and still be intact. To solve the dichotomy between k-core percolation on hypegraphs and on factor graphs, we define a set of pruning processes that act either exclusively on nodes or exclusively on hyperedges and depend on their second-neighborhood connectivity. We show that the resulting second-neighbor k-core percolation problems are significantly distinct from each other. Moreover we reveal that although these processes remain distinct from factor graphs k-core processes, when the pruning process acts exclusively on hyperedges the phase diagram is reduced to the one of factor graph k-cores.

Published by the American Physical Society
2024
Analysing resilience and leagility in post-pandemic sustainable supply chain management: a systematic literature review
Authors: Gupta Naresh , Gunawan Indra , Kamineni Rajeev
Published: January 2024

Purpose

This study aims to comprehend the role of leagility and resilience in developing sustainable global supply chains, mitigating short-term disruptions and long-term economic impacts from various disasters, in the context of Australian civil infrastructure projects.

Design/methodology/approach

The study employs systematic review approach to establish that addressing project success dimensions (i.e. leagility, resilience and sustainability) requires an integrated and extended supply chain approach, encompassing traditional supply chain strategic model elements (i.e. cost/capital, quality and service goals) and supply chain eco-system (i.e. organisations, societies, economies and nature).

Findings

The study underscores the need to enhance supply chain leagility and resilience to achieve sustainability. This can be achieved by developing skills needed to plan across project phases and time frames, aligning with short and long-term organisational goals, assuming smart risks in the face of uncertainty.

Research limitations/implications

This study extends the traditional supply chain strategic model by introducing new priorities to minimise the consequences of disruptions and to effectively respond to them. The integration of leanness, agility and resilience ensures a sustainable supply chain even in the times of uncertainty, disruption and volatility.

Originality/value

This research provides an opportunity for practitioners and policymakers to rethink and redesign the conventional supply chain model of cost, capital, quality and service objectives. It introduces pioneering concepts by acknowledging and incorporating emerging priorities, especially in Australian civil infrastructure projects. The study integrates leagility and resilience into the existing strategic framework, adding crucial dimensions for sustainable supply chains in infrastructure companies.