bluuebunny/crossref_metadata_2025 huggingface dataset:
THE LEGAL CONSEQUENCES OF A COOPERATION AGREEMENT DUE TO MERGER
Authors: Rafif Zulfikar Muhammad
Published: July 2022

Cooperation agreement is a bond between one party and another party to bind themselves in doing or not doing something in particular. Basically, the agreement creates rights and obligations by the parties and is regulated in the Civil Code. Companies when running their business often carry out corporate actions aimed as a way to survive and to increase company profits, one of which is by merging the company. Mergers are often used apart from the relatively low cost, the methods and mechanisms that are carried out are simpler so that they become more efficient. Research methods used in writing this paper is a normative juridical method. Often problem arise in mergers are doubts and uncertainties in determining the legal consequences of an agreement, including cooperation agreement with third parties that were made prior to the merger. The legal consequence of a merger is the company’s assets and liabilities are transferred directly without going through a liquidation process. If during the merger, one of the companies is still bound by a cooperation agreement with a third party, then the rights and obligations contained in the cooperation agreement are transferred by law without needed a deed of transfer to delivered these rights and obligations.
Conflict potential of modern social and labor relations
Authors:   PJSC “LUKOIL”, Moscow Russia, Pakhomova Elena I. 
Published: July 2022

The article examines the issues of protection of labour rights by Russian employees, that led to heated discussions at working meetings of employees of the Center for Comprehensive Social Research of FCTAS RAS, when it came to life values ​​and the potential for protest activity. One of the main questions raised by V.V. Petukhov - Why, despite the importance and significance for many Russians of such a sphere of life as work, nevertheless, few people are ready to defend their labour rights by any means, in fact, rather adapting to the situation and often deliberately worsening their situation? The starting point for working on this text was an article by V.V. Petukhov "Crisis and protection of labour rights of citizens”, published in the journal "Sociological Research" in 2016. The main idea expressed in the article is to continue the scientific discussion of the ongoing changes in the social and labour sphere that characterise the behaviour of modern workers in cases of infringement or violation of labour rights. In the presented article, the author, continuing the reflections of V.V. Petukhov, demonstrates, based on the empirical data collected in the course of many years of research by the ISRAS, what tactics of labour behaviour and ways of defending the rights and interests are chosen by Russian workers, how they assess today the level of opportunities to influence the adoption of managerial decisions at the place of work, the ability to influence the improvement of working conditions. Based on the analysis, the author comes to the conclusion that in modern conditions, social and labour relations in Russia are not yet a favourable environment for the development of professional and qualification competencies, for productive and efficient work. Difficulties with the realisation of the labour rights of citizens, when the legal possibility of defending them is either not realised or is blocked, can lead to the radicalisation of certain groups of citizens. Moreover, the "foci" of such radicalisation, in the author´s opinion, will be localised in socio-professional groups and industries where the conditions of short-term (precarious) employment are most widespread.
Pro-inflammatory response features in myocardial infarction in northern mongoloids exemplified by the buryat population
Authors:   Republic clinical hospital named after N. A. Semashko, Donirova O.S. , Protasov K.V. ,   Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional Education, Batunova E.V. ,   Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional Education, Bardymova T.P. ,   Irkutsk State Medical Academy of Postgraduate Education – Branch of Russian Medical Academy of Continuing Professional Education, Tsyretorova S.S. ,   Irkutsk City Hospital N3
Published: July 2022

The aim of the research. To study the biomarkers of inflammation in acute ST-elevation myocardial infarction (STEMI) in patients of the Buryat ethnic group in comparison with Russian patients. Material and methods. In 109 patients with acute STEMI of Buryat (n = 43) and Russian (n = 66) nationalities, as well as in 42 healthy donors (20 Buryats and 22 Russians), serum levels of high-sensitivity C-reactive protein, interleukin-1β (IL-1β ), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10) and tumor necrosis factor-α (TNF-α), as well as IL-6/IL-10 and IL-8/IL-10 ratios were evaluated and compared between the ethnic groups with consideration for the clinical data and STEMI severity, as well as in the groups of healthy patients and those with STEMI. Results. The study groups did not differ in gender and age. Compared to healthy subjects in the STEMI group, the concentration of all inflammation biomarkers was higher regardless of ethnicity, with the exception of IL-1β, which significantly increased in Caucasians only. According to the results of comparative analysis, patients with STEMI of the Russian group matched to that of the Buryat, had higher levels of IL-1β (1.46 [0.41-3.67] and 0.02 [0.01- 1.12] pg/ml, respectively), TNF-α (2.1 [1.4-3.0] and 0.9 [0.4-2.2] pg/ml), IL-6/IL-10 ratios (4.9 [3.5-7.8] and 3.4 [1.7-6.7]) and IL-8/IL-10 (37.6 [8.1-63.4] and 11.9 [5.8-30.7]), troponin T (2.5 [0.19-15.5] and 0.38 [0.11-2.7] ng/ml), creatine phosphokinase-MB (29.4 [17.3-89] and 19.0 [12-26] IU/l), and lower body mass index (24.9 [22.5-28.4] and 27.3 [25.1-31.0] kg/m2) and left ventricular ejection fraction (51.5% [44-57] and 55.0% [50-58]). After adjustment for gender, age, and body mass index, the association with ethnicity remained significant for IL-1β (F for the general regression model was 5.28; p = 0.024) and the IL-6/IL-10 ratio (F = 4.43; p = 0.037). Conclusion. The pro-inflammatory response against the background of STEMI in the Buryat ethnic group as compared to the Russian one is characterised by lower levels of IL-1β, TNF-α as well as lower IL-6/IL-10 and IL-8/IL-10 ratios. After adjustment for gender, age, and body mass index, differences in ethnic groups remained significant for IL-1β and IL-6/IL-10, which indicates a less pronounced proinflammatory response in STEMI patients of the Buryat nationality.
Self-perceived dental health and its association with caries experience and sociodemographic factors among 15-years old adolescents in the Arkhangelsk region
Authors:   Northern State Medical University, Gorbatova M.A. , Akulova I.S. ,   Northern State Medical University, Gorbatova L.N. ,   Northern State Medical University, Simakova A.A. ,   Northern State Medical University, Grjibovski A.M. ,   Northern State Medical University
Published: July 2022

The aim of the research. To study self-perceived dental health of adolescents and to determine its association with socio-demographic factors and objective data on the condition of teeth. Moreover, we assessed the prognostic value of models based on the studied indicators as tools for caries prognosis in 15-years old teenagers. Material and methods. A total of 1143 15-years old adolescents from 7 urban and 5 rural settings took part in a cross-sectional study. Questionnaire surveying and objective assessment of dental health was performed using the standardised and validated WHO methodology. The decayed (D), missing (M) and filled (F) teeth (T) counts were combined in the DMFT index and presented with 95% confidence intervals (CI). Bivariate analysis of categorical variables was performed using the chi-squared test. Numeric variables were compared using the Kruskal-Wallis test. The association between socio demographic factors and self-perceived dental health independently from caries experience was evaluated using multivariate ordinal regression. The prediction of caries based on the studied factors was performed using logistic regression models. Results. Only 14.4% of the adolescents characterised their dental health as excellent or very good while 10.7% reported having bad or very bad teeth. The mean DMFT index in the abovementioned groups varied between 2.9 (95% CI: 2.5-3.3) and 6.5 (95% CI: 5.8-7.3). Significant linear trends between selfperceived health and objectively measured caries experience was observed (p < 0.001) and explained by the difference in the number of decayed teeth (p < 0.001). The place of residence and parents’ education were significantly associated with self-perceived health both in bivariate analysis and after adjustment for caries experience. In the multivariate logistic model, self-perceived dental health was the most significant factor in prognostic models contributing with 7.8% out of 8.5% of the total variance. Conclusion. Self-perceived dental health in adolescents is significantly associated with objectively assessed caries experience. Social factors are significantly associated with self-perception of dental health even after adjustment for objective data. However, the coefficients of determination of the prognostic models are too small, which precludes their application for prognosis of caries development based on self-reported data in the studied population.
Clinical phenotypes of sarcoidosis patients in real clinical practice
Authors:   Privolzhsky Research Medical University, Postnikova L.B. , Gudim A.L. ,   City Clinical Hospital No. 38, Boldina M.V. ,   Privolzhsky Research Medical University, Kubysheva N.I. ,   Federal State Autonomous Educational Institution of Higher Education, Kazan (Volga region) Federal University
Published: July 2022

The aim of the research. To identify clinical phenotypes of sarcoidosis using cluster analysis based on clinical and demographic characteristics and the results of laboratory and instrumental analysis of patients in real clinical practice. Material and methods. We retrospectively studied the data of outpatient records of 276 sarcoidosis patients (107 males, 169 females) aged 20-68 years (41 (30; 55) years), who had been observed for more than 2 years. We analysed the gender characteristics of the patients, the forms of sarcoidosis, clinical symptoms, laboratory and functional parameters, X-ray stages, extrapulmonary lesions, and comorbid conditions. Results. A total of 5 clusters were identified using two-step cluster analysis. Cluster 1: female and male patients with acute or chronic form of pulmonary sarcoidosis (PS) and extrapulmonary manifestations; cluster 2: women with chronic asymptomatic PS; cluster 3: females with the chronic form of clinically relevant PS; cluster 4: male patients with the chronic form of asymptomatic PS; cluster 5: men with the chronic form of clinically associated PS. In contrast to cluster 4 patients with the criteria of favorable PS course, the risk of sarcoidosis progression was 7 times higher for cluster 1 patients (OR=7.01; 95% CI 2.53- 22.95; p<0.001), and 5.7-fold higher for cluster 3 patients (OR=5.73; 95% CI 2.25–17.73; p<0.001). Patients of clusters 2 and 5 had no significant differences in laboratory and instrumental parameters compared to cluster 4 patients (p>0.05). Conclusion. Identification of clinical phenotypes of sarcoidosis in patients in clinical practice based on clinical, demographic, laboratory, functional and radiological characteristics, makes it possible to optimise the therapy choice and predict the course of the disease
Embolia de líquido amniótico.
Authors: António Carlos , Marçal Nelson , Lopes Carlos , Tortosa Francisco , Acevedo Pilar , Monteiro Jorge , Monteiro Filipe , Correia Llurdes , Brum Ganriela , De Almeida A Bugalho
Published: July 2022

Amniotic fluid embolism (AFE) is a rare pathological syndrome, sometimes fatal that arises as an obstetric complication during vaginal delivery, caesarean, immediate postpartum or during pregnancy. It remains as an important cause of fetal and maternal morbidity and mortality. The authors present a clinical report of a young woman who developed an acute respiratory failure during labour demanding invasive mechanical ventilation and an urgent caesarean. In spite of early medical intensive therapy, hypoxemia was refractory and had a progressive worsening leading to multi-organ failure and ultimately to death. Diagnosis was confirmed through the identification of fetal material in the lumen of maternal pulmonary microcirculation.
GIST: gastrointestinal stromal tumors.
Authors: Uria Sara , Cachado Ana Patrícia , Garcia Teresa
Published: July 2022

GIST (Gastrointestinal stromal tumors) are rare tumors of mesenchymal origin. The authors present a case of GIST in a 80 years old female with multiple co-morbilities, admitted with epigastric pain, gastrointestinal bleeding and heart failure decompensation.
Esofagite eosinofílica: diversidade de expressão clínica em idade pediátrica.
Authors: Rodrigues Ana Luísa , Palha Ana Maria , Lopes Ana Isabel
Published: July 2022

Eosinophilic esophagitis is an emerging chronic oesophageal inflammatory disease, increasingly recognized both in children and in adults. It is presently accepted that this entity has a chronic course with persistent or relapsing symptoms and a wide range of clinical manifestations at different age groups: in children it is responsible for feeding disorders, vomiting or abdominal pain; in teenagers and adults it causes dysphagia and oesophageal food impaction. The etiopathogenesis of eosinophilic esophagitis has not been yet well established, but immuno-allergic mechanisms associated with a Th2 immune response have been proposed. Diagnosis is based both on clinical and histological grounds, requiring that oesophageal mucosal biopsy specimens obtained from different oesophageal locations contain more than 15 intraepithelial eosinophils per high power field and the exclusion of gastroesophageal reflux disease. Currently proposed effective treatments rely on eviction of putative allergens through dietary exclusion and on treatment with swallowed steroids. We describe two cases (a young child and a teenager) illustrative of the clinical spectrum and course variability of eosinophilic esophagitis at pediatric age. A brief review of current knowledge concerning this puzzling clinical entity is presented, emphasizing specific diagnostic dilemmas and questions concerning its long-term follow-up.
Neuroimagem cerebral com imagem ponderada em susceptibilidade.
Authors: Lima Paula Bastos , Freitas Diogo , Marques Cátia , Rio Fátima
Published: July 2022

The Susceptibility-weighted (SWI) imaging is a recent MRI sequence that shows the magnetic susceptibility differences of various tissues. A large number of neurological / neurosurgical diseases can benefit with this MRI sequence. The basic physics principles are reviewed and also its clinical application in several brain pathologies in adults and in paediatrics, mainly vascular, tumors and neurodegenerative/genetic disorders. Some clinical cases show the utility of SWI. The anatomic detail of some brain structures, the deep venous system and mesencephalic structures is shown.
Perspectivas futuras no tratamento da psoríase: novidades em terapêutica biológica.
Authors: Diamantino Filipa , Ferreira Ana
Published: July 2022

Psoriasis is an immune-mediated chronic, inflammatory disease. Due to the chronic nature of the disease, patients suffer from substantial psychological and financial burdens, thus adding to a significantly impaired quality of life. Current understanding of the pathophysiology of this condition has produced very encouraging new medical developments. The biologic therapies target precise elements of the immune cascade and their introduction to clinical practice was a significant advance in the management of refractory moderate-to-severe psoriasis. Biological therapies for the treatment of psoriasis and/or psoriatic arthritis are defined by their mode of action and are classified into the following categories: T-cell modulating agents, inhibitors of tumor necrosis factor-alpha (TNFα blockers) and inhibitors of interleukin (IL) 12 and IL-23. This article reviews the recent progress in the understanding of the molecular and immunologic basis of psoriasis and how this contributed to the introduction of new targeted therapies. It is provided an overview of the TNFα inhibitors golimumab and certolizumab, and also other agents such as ustekinumab, briacinumab, tasocitinib, sipilizumab and abatacept.
Factores de risco para a progressão da ingestão alimentares por via oral de doentes com doenças neurológicas degenerativas em acompanhamento em terapia de fala.
Authors: Nunes M Cristina , Duarte Silvana , Palmonari Aline , Rockland Adriano , Furkim Ana M
Published: July 2022

Currently studying the speech voice therapy effectiveness in cases of oropharyngeal dysphagia has been deepened and included the variables that prevent the patient develops treatment.To study the possible risk factors for progression of food intake by mouth during the speech accompanying dysphagia in patients hospitalized with degenerative neurological diseases.Retrospective study conducted at the Department of Speech Therapy in a General Hospital from January 2007 to May 2008. Were collected 117 records of patients with oropharyngeal dysphagia, and only 15 (12.8%) were diagnosed with degenerative neurological disease, evolved with complaints of dysphagia and underwent speech therapy. We used myofunctional orofacial and vocal exercises for rehabilitation. We applied Fisher's exact test and nonparametric test Mann-statistical analysis of possible relationship with risk factors, namely clinical events during therapy and respiratory conditions of patients.Study participants were 11 (73.3%) female patients and four (26.7%) males. Ten (66.7%) patients who progressed on the ability of oral intake and had less time in therapy, 11 (73.4%) did not present any problem, two (13.3%) had worsening of symptoms and two (13.3%) had a lowered level of consciousness during the therapeutic process. Ten of 15 patients (66.7%) showed progression in the ability of oral intake according to clinical assessment (range FOIS®), five (33.3%) remained the same conditions prior to therapy and no patient had worsening oral intake.The level of consciousness and respiratory complications in this study were associated with poor prognosis for the progression of oral in speech therapy.
Massas mediastínicas: análise de uma casuística.
Authors: Monteiro Rita , Alfaro Tiago M , Correia Lurdes , Simão Adélia , Robalo Cordeiro Carlos , Carvalho Armando , Costa J M Nascimento
Published: July 2022

Mediastinal masses are tumoral lesions arising from intra-thoracic organs. They are an infrequent diagnostic challenge, requiring a structured clinical and radiological approach.The study of the clinical, radiological and pathological characteristics, treatment and prognosis of patients, with mediastinal masses, admitted to an Internal Medicine ward in an University Hospital.A retrospective analysis of the medical records of patients with this diagnosis made between years 2000 and 2008.Twenty-eight patients were included (15F/13M), with a mean age of 55.5 years (17-88). Twenty-six patients presented with symptoms, most frequently, dyspnoea, fatigue, dry cough, chest pain and anorexia. At examination, six exhibited superior vena cava syndrome. Chest X-ray showed pathological changes in 26. Chest CT scan added relevant information in all cases whenever it was performed. Histology was most frequently obtained by mediastinoscopy, open surgical biopsy, percutaneous thoracic biopsy and at necropsy. Histological diagnosis was not possible in ten patients. Final diagnoses included: lymphoma in four patients; sarcoidosis, thymic hyperplasia and undifferentiated squamous carcinoma of unknown origin in two patients each; other diagnosis in single cases were: thyroid teratoma, thymoma, atrial myxoid malignant fibrous histiocytoma, ganglioneuroblastoma, neuroendocrine thymic carcinoma, squamous cell lung cancer and germinative cell tumour. Thirteen patients were submitted to surgery, chemo and/or radiotherapy. Fifteen patients died during admission or when in follow-up.At our center, mediastinal masses are frequently of a malignant origin, affecting relatively young people; a late diagnosis and an associated poor prognosis was the rule, prompting for early intervention to improve outcome.
Como Fazer Pesquisa Bibliográfica com Eficácia? As Estratégias do Push e Pull
Authors: Donato Helena , Tato Marinho Rui
Published: July 2022

O volume de informação científica disponível está a crescer exponencialmente. Os profissionais de saúde que querem manter-se actualizados com a literatura científica e encontrar a melhor informação devem investir o seu tempo a encontrar recursos que sintetizam a melhor evidência. Os objectivos deste artigo são proporcionar a aquisição de competências e conhecimentos ao nível da pesquisa bibliográfica; contribuir para o aumento da utilização dos recursos electrónicos e ‘empurrar, puxar’, ‘Push and Pull’ a informação correcta, ou seja indicar como lidar com o excesso de informação.
Tratamento Cirúrgico da Espondilodiscite Tuberculosa: Experiência de um Serviço de Ortopedia
Authors: Soares do Brito Joaquim , Batista Nuno , Tirado António , Fernandes Pedro
Published: July 2022

Introdução: A espondilodiscite de etiologia tuberculosa é responsável por mais de 40% do universo destas infeções. Enquanto a quimioterapia tuberculostática se mantém como gold-standard da terapêutica desta patologia, o tratamento cirúrgico tem lugar em situações muito específicas. Neste trabalho apresentam-se os resultados de 33 doentes com espondilodiscite tuberculosa operados no nosso serviço durante os últimos 15 anos.Objetivo: Avaliar retrospetivamente doentes com diagnóstico de espondilodiscite tuberculosa operados num período de 15 anos(1996 a 2011); avaliar opções cirúrgicas tomadas e respetivos resultados relativamente à resolução da infeção, controlo da deformidade e evolução da lesão neurológica.Material e Métodos: Análise retrospetiva dos processos clínicos e avaliações imagiológicas de doentes com diagnóstico de espondilodiscite tuberculosa operados entre 1996 e 2011. Foram identificados 33 doentes com idade média de 46,7 anos; 17 doentes apresentavam infeção torácica, 11 lombar e cinco toraco-lombar. O abcesso paravertebral foi identificado em 26 dos casos estudados, existindo extensão intracanalar em 16 doentes. Nove dos doentes avaliados apresentavam lesão neurológica. A abordagem cirúrgica por via anterior foi utilizada em sete casos, a via posterior em 11 e a abordagem combinada foi a preferida em 15 ocasiões. A quimioterapia antibacilar foi mantida em média por 14 meses, com seguimento médio de 24 meses.Resultados: Verificámos cura da infeção em todos os doentes, sendo documentados critérios de fusão óssea, em média, 10,6 meses pós-cirurgia. A abordagem anterior isolada não permitiu obter correção da deformidade inicial, enquanto a via posterior permitiu uma correção média de 12,7º e a via combinada uma correção média de 8,7º. Cinco dos doentes com lesão neurológica melhoraram 2 a 3 níveis na escala ASIA durante o seguimento pós-operatório. Como complicações referem-se 2 casos de infeção superficial da ferida operatória.Discussão e Conclusão: A terapêutica com antibacilares constitui a terapêutica de primeira linha no tratamento da espondilodiscite tuberculosa, existindo indicações específicas para realização de cirurgia. A intervenção cirúrgica, quando indicada, permite corrigir a deformidade assim como a fusão óssea, sendo preferencialmente realizada por via combinada ou posterior. A taxa de complicações foi pouco significativa apesar da introdução de material de osteossíntese.
Psychiatry Training Towards a Global Future: Trainees’ Perspective in Portugal
Authors: Pinto da Costa Mariana , Guerra Cátia , Malta Rui , Moura Manuela , Carvalho Serafim , Mendonça Denisa
Published: July 2022

Introduction: Psychiatry is influenced by society changes, so it should be permanently updating itself, foreseeing future behaviours and pathologies. This study aims to describe psychiatry trainee’s opinion in Portugal concerning their training and the modifications they would want to witness in the near future.Material and Methods: A structured questionnaire of 26 questions was developed by the Portuguese Association of Psychiatry Trainees and sent via email.Results: The percentage of responses was 41.5%. The majority of the trainees were satisfied with their formation. However, some changes were pointed out concerning obligatory and optional placements. Most trainees claimed psychotherapy should be included in their training, along with an easier access to investigational procedures and clinical training opportunities abroad.Discussion and Conclusion: This detailed perspective can facilitate the transformation of the curricula throughout Portugal and Europe, allowing the improvement of psychiatry training, as well as the enhancement of mental health care.
Métodos diagnósticos em tuberculose.
Authors: Bento João , Silva Anabela Santos , Rodrigues Filomena , Duarte Raquel
Published: July 2022

Early diagnosis and treatment are critical to minimize the spread and to reduce morbidity and mortality from tuberculosis. Clinical diagnosis is most time difficult resulting from non-specific and frequently indolent symptoms. Radiological presentation may be very diverse. Currently TB diagnosis still depends on microbiological exams which require a very careful and quick specimen handling. A positive acid-fast bacilli smear makes a rapid presumptive diagnosis. Nevertheless the gold-standard for diagnosis still is cultural-isolation of the Mycobacterium tuberculosis, which may take several weeks to attain. Biochemical (adenosine deaminase) and molecular techniques (nucleic acid amplification tests) are already approved for tuberculosis diagnosis and can provide rapid diagnostic information to the clinician. Numerous alternative diagnostic methods are still under experimentation but none of them has a recognized role. In most cases diagnosis of tuberculosis lays on an adequate combination of different diagnostic methods which is time-consuming. Even though in some cases laboratory confirmation is never obtained and diagnosis and treatment is established on suspicious basis. The purpose of this paper is to discuss the utility of the several diagnostic methods currently available and to point out most common difficulties found by the clinicians to the correct and timely diagnosis.
Úlcera flebostática: estudo prospectivo de 202 doentes.
Authors: Fradique Caldeira , Pupo Alexandra , Quaresma Luísa , Palma-Rosa Ana , Fernandes Mário , Silva Gualdino , Almeida Heitor , Diogo Cláudia , Pinho Ana Catarina
Published: July 2022

During 16 years 202 patients with leg ulcer have been studied prospectively. Whenever possible, cure has been obtained in ambulatory, which was the main objective. Surgery was preferentially made after the cure of the ulcer. From the 202 patients, 166 have made a prolonged follow-up. Cure in ambulatory has been obtained in 91% of the patients. We stress the importance of the direct control of all the treatment by the responsible doctor.
Papel do HER2/NEU sérico como factor preditivo e de monitorização no cancro da mama sob terapêutica com trastuzumab.
Authors: Couto Maria do Rosário , Pinto Daniela , Oliveira Júlio , Monteiro Alice , Pereira Deolinda , Medeiros Rui , Rodrigues Helena
Published: July 2022

In breast cancer, the Human Epidermal growth factor Receptor 2 (HER2) is associated with worst prognosis in all stages of the disease, and it is specifically targeted by a monoclonal antibody (trastuzumab). Nevertheless, the different response rates observed have increased the search for better predictive markers. Elevated levels of the extracellular domain of HER2/neu in the serum have been associated with the clinical outcome of breast cancer patients.The authors proposed to analyze serum HER2/neu in breast cancer patients, under treatment with trastuzumab, in monotherapy or associated with another systemic therapy, either in adjuvant or metastatic setting, in order to evaluate its role as prognostic, predictive and monitoring factor. From March 2007 to May 2008, 173 serum samples from 43 patients were analysed, corresponding to the beginning of the treatment of trastuzumab and 3/3 months afterwards. Serum HER2/neu levels were measured with ADVIA Centaur(®) immunoassay and levels > 15 ng/mL were defined as elevated, according to previous reports.Elevated baseline serum levels were found to be associated with a worst overall survival (p = 0,003). In the metastatic setting, baseline HER2/neu serum levels were not associated with response rate to trastuzumab. However, when we analyzed the variations in HER2/neu serum levels between the response evaluation date and the first measurement, we observed that patients whose serum levels declined showed significantly higher objective response compared with patients with stable or elevated serum values (p = 0,001). Moreover, monitoring early changes in serum levels (three months) could also predict the probability of response to trastuzumab-based treatment (p = 0,007).The use of this predictive potential could not only focus and tailor treatment individually but also adapt to economic needs.
Avaliação das Alterações Hemodinâmicas em Pacientes com Diagnóstico de Doença de Buerger
Authors: Vicente Inês , Alves Ana , Pereira Alexandre , Roncon de Albuquerque Roberto
Published: July 2022

Introduction: Buerger’s disease or thromboangiitis obliterans (TAO) is a vascular disease characterized by vascular and segmental occlusion of small and medium-sized arteries of the extremities, caused by an inflammatory and thrombotic phenomena. The aim of this study was to evaluate functionally the hemodynamic consequences of this disease and its main arterial vascular changes. Methods: A retrospective clinical study was conducted with a sample of 100 patients diagnosed with TAO, who underwent to follow-up appointments every two years for peripheral arterial doppler, plethysmography and ankle-brachial index (ABI) at the Department of Angiology and Vascular Surgery of the Hospital de São João in Porto. To conduct the study, the last hemodynamic evaluation of each patient was selected between 2004 and 2010. Results: It was observed that tobacco has an unquestionable role in TAO, both in the rate of limb amputations (p = 0.006) and ABI values, with significant differences between non-smokers and groups of former and current smokers. Monophasic flow patterns are associated with low resistance spectrum and lower ABI values when compared to biphasic and triphasic flow patterns (p < 0.001). Normal ABI have a lower prevalence of collateral arteries associated in the right (p = 0.005) and left limbs (p = 0.032). Discussion/Conclusion: The clinical manifestations of peripheral vascular disease characteristic of TAO were reflected hemodynamically with monophasic low-resistance patterns associated with altered
Análise custo-efectividade do samário-153-EDTMP versus terapêutica convencional da dor em doentes com metástases ósseas múltiplas dolorosas em Portugal.
Authors: Macedo Ana , Araújo António , Melo Fernando Carvalho , Nunes Garção , Cantinho Guilhermina , Amorin Inêz
Published: July 2022

Prostate cancer is a significant cause of morbidity and mortality. In Portugal alone, according to a study published in 2003, the rate of new prostate cancer cases were 53 per 100,000 men (in 2000), with an age-standardized mortality rate of about 28 per 100,000 (in 1995). Multiple bone metastases are one of the major complications of advanced prostate cancer. Samarium-EDTMP showed to be a safe and effective alternative for palliative treatment of bone metastases. The goal of this economic study is to assess the cost-effectiveness of Samarium-153-EDTMP for the treatment of pain due to multiple bone metastases in hormone-refractory prostate cancer versus conventional pain therapy, in Portugal.Cost-effectiveness study that compares the expected direct costs to the National Health System of managing patients with painful multiple bone metastases with Samarium-153-EDTMP versus conventional pain therapy, in Portugal, in a 4-moths period.The total direct 4 months cost was 2,311.91 euro for a patient treated with Samarium-153-EDTMP versus 2,450.74 euro for a patient under standard treatment. According to the model a patient treated with Samarium-153-EDTMP represents a 138.83 euros saving.Samarium-153-EDTMP was not only a very effective therapeutic option but also an option with less cost than the conventional pain therapy, in patients with pain due to multiple bone metastases, in Portugal.
Avaliação ecográfica do colo uterino e rastreio de parto pré-termo: método útil ou ainda controverso?
Authors: Loureiro Teresa , Cunha Manuela , Montenegro Nuno
Published: July 2022

Preterm delivery is a major concern in Maternal-Fetal Medicine. The sonographic measurement of the cervix is a reproducible and safe method to assess cervical length. Many authors have shown the benefits of cervical assessment in the screening of pregnant women at risk of preterm labor. Although screening could be useful in women at high-risk for preterm spontaneous labor, in a low-risk population the accuracy of the method is limited. An important issue is the usefulness of cervical cerclage to prevent preterm birth when a short cervix is detected by ultrasonography. In this review, the authors present new evidence of recent literature reporting sonographic measurement of cervical length and prediction of spontaneous preterm birth.
Protocolo de revisão de utilização de recursos num hospital público Português.
Authors: Almeida Anabela , Serrasqueiro Zélia , Rogerio Ana
Published: July 2022

This paper reports on some important findings of a study conducted in Covilhã/Portugal on appropriateness of hospital admission and in-hospital days in a Portuguese hospital using an adapted version of the Appropriateness Evaluation Protocol--a review tool for hospital utilization. This analysis showed a significant rate of inappropriateness in admission (24.6%) and days of stay (37.4%) and it also suggested a low rate of use of the override options. It was possible to identify the conservative attitude as the most common cause of inappropriate admissions and days of stay. This study demonstrates that a high proportion of admissions and days of stay are related to patients who could have been attended at other levels of the health care system such as outpatient consultations. The analysis made it possible to identify and to explore some variables correlated to the levels of inappropriateness and to the causes of inappropriateness or levels of health care required by the patients.
Utilização de sangue em cirurgias programadas.
Authors: Oliveira Ana , Fleming Rita , Galvão Miguel
Published: July 2022

For elective surgeries over ordering of blood is a common practice. The goal of the Maximum Surgical Blood Order Schedule (MSBOS) is to promote efficient use of blood. The purpose of this Portuguese study is to analyse the crossmatched blood units for elective surgery and the real amount of transfused blood, the crossmatch:transfusion rate (C:T) which must be less than 2.5. As in other Blood Banks, the differences are more evident in the situations in which the need for blood is very small, the so called Type and Screen. MSBOS should be re-evaluated regularly because of operative environment such as surgeons, operative methods, haemostatic drugs and preoperative conditions of patients can change.
Aplicação da modelagem da informação da construção nas atividades de manutenção e operação de edificações
Authors: Borrelli Elis Mayumi Yamamoto , Scheer Sergio
Published: July 2022

Os gerentes de instalações gastam muito tempo para encontrar as informações necessárias para apoiar suas atividades de manutenção e operação. Para melhorar o desempenho na identificação das informações a Modelagem da Informação da Construção (Building Information Modeling - BIM) pode ser utilizada. A presente pesquisa teve como objetivo explorar uma estrutura de requisitos para aplicação de um projeto desenvolvido em BIM de modo a gerar modelos adequados ao uso no gerenciamento da manutenção e operação de edifícios. A estratégia de pesquisa foi a de um estudo de caso, utilizando um projeto piloto desenvolvido em BIM, em LOD 300, que foi atualizado para a utilização em atividades de manutenção e operação. Para a transferência dos dados utilizou-se ferramentas como o Revit e o YouBIM e o esquema de dados COBie. Também foi exposto como o setor de manutenção e operação opera atualmente (as-is) e, futuramente, como poderá melhorar (to-be) com a utilização do BIM aliado a um software de Facility Management (FM) para auxiliar no gerenciamento das atividades de manutenção e operação das edificações. Além disso, foram expostos os desafios da importação de dados, a integração da documentação de FM com o BIM, o controle de qualidade de dados do BIM e os elementos que foram atualizados para o LOD 500. Como resultados do estudo de caso, foi elaborado um quadro com os requisitos utilizados nesta pesquisa para a aplicação do BIM em FM para manutenção e operação e, como contribuição, foi apresentada uma sugestão de fluxo em BIM para FM utilizando a notação Buissiness Process Modelling Notation (BPMN).
EFFECT OF HEATED CANOLA OIL ON AORTA WALL THICKNESS IN RATS
Authors: Aziz Mochammad Abdul , I’tishom Reny , Rejeki Purwo Sri , Yuliawati Tri Hartini
Published: July 2022

Highlights:
1. The use of re-heated cooking oil can give negative impact on health,  especially on the cardiovascular system.
2. Unlike other types of cooking oil, repeated heating of canola oil did not show significant change in aortic wall thickness.
Abstract
Background: Structural alteration of blood vessels such as formation of atheroma or changes in the thickness of vessel walls, are heavily involved in pathogenesis of cardiovascular disease. Several studies have shown that canola oil has a positive effect on such diseases by reducing LDL and cholesterol levels. However, there may be several negative impacts on reheating canola oil upon administration, similar to other oils. Although canola oil can improve lipid profiles, studies related to how canola oil alters the structure of blood vessels are limited. Objective: The aim of this study was to investigate the effect of heated canola oil on intimal-to-medial thickness (IMT) of Thoracic aorta in high-fat diet rats. Material and Method: A total of 27 rats were divided into 3 groups, the K+, P1, and P2. Rats among the three groups were given a high-fat diet for 14 days, accompanied by consumption of canola oil without heating in the P1, and with repeated heating in the P2. Thoracic aorta was taken on the 15th day and then processed into histological preparations. IMT was measured using CellSens software on a microscope with a magnification of 400. The difference between groups was tested using the one-way ANOVA test on SPSS. Result: The mean and standard deviations of each group in a row were K+ (134.96 and 21.27) P1(132.04 and 27.30) and P2 (152.05 and 31.75). There was no significant difference in IMT between groups (p >0.05). However, the P2 group showed the highest mean of IMT. Conclusion: The consumption of canola oil with or without repeated heating did not result in the changes of the IMT in rats fed with a high-fat diet.
MITIGATION OF SOIL-TRANSMITTED HELMINTHIASES RESURGENCE IN THE ERA OF COVID-19 DISRUPTION: A LITERATURE REVIEW
Authors: Falah Pilar Menara , Yani Corvianindya Rahayu  , Atik Kurniawati  , Yudha Nurdian
Published: July 2022

Highlights:

1.    Prolonged interruptions and delays that accompany the COVID-19 pandemic have further increased the spread of STH in high-transmission areas.2.    Adaptations carried out in the context of a pandemic are able to strengthen efforts to sustain deworming programs based on primary health facilities and their integration into community-based platforms.3.    Community-based WASH activities must be continued by adjusting WASH messages to focus on preventing the transmission of COVID-19.

Abstract:
Background: Interruptions and postponements are influencing people’s desire for soil-transmitted helminthiases (STH) services as all countries are fighting the Covid-19 pandemic. The risk of spreading STH in high-transmitting areas increases with increased disturbance. Indonesia is a compatible host country for STH because it is a tropical country. The STH impacts the population’s nutrient status and disturbs their cognitive processes. Objective: To describe the issue and how best efforts had been made to mitigate the possibility of a resurgence of intestinal worms during the disruptions caused by the Covid-19 pandemic. Material and Method: Search for the most recent articles in a database of research in January 2022 on Google Scholar, Science Direct, and PubMed. Qualifying articles were then extracted and synthesized qualitatively. Discussion: The interference and postponement of the deworming control program due to COVID-19 had a tentative effect on the progress of achieving the elimination of STH as a public health problem by 2030. Conclusion: Best practices show that revitalization efforts to control STH by strengthening integrated interventions and collaborations through the expansion of POPM, PHBS, and STBM in line with COVID-19 prevention efforts with mitigation innovations shifting from controlling morbidity to terminate the transmission of STH.
Az önkontroll és az evési magatartás szerepe az elhízásban a fiatalok körében
Authors: Prónay Szabolcs , Krisztik-Pető Dalma
Published: July 2022

Az elhízás és a kapcsolódó betegségek kezelése napjainkban globális szinten probléma. Ez nemcsak az egyén, hanem a gazdaság számára is óriási teher. Ezek a betegségek azonban megfelelő táplálkozással megelőzhetők. Kutatásunk célja a testsúlykontrollra és az elhízásra ható tényezők megismerése. Jelen tanulmányban kutatási területünket két kulcstényezőre szűkítjük le: az evési magatartásra és az önkontrollra. Ezen összefüggések vizsgálatára egy kutatási modellt hoztunk létre. Elméleti modellünket a részleges legkisebb négyzetek (PLS) technikával vizsgáltuk, amely a strukturális egyenletek modell (SEM) egyik legszélesebb körben használt technikája a látens változó modellezésben. Eredményeink azt mutatják, hogy a BMI szintet az evési magatartás befolyásolja, az önkontroll pedig az evési magatartáson keresztül hat a testsúlyra.
JEL-kódok: I12, M31
Az élelmiszer-vásárlási szokások változása a Covid járvány alatt Szlovákiában és Magyarországon, helyzetkép Dél-Szlovákiában és Nyugat-Magyarországon
Authors: Molnár Anna , Józsa László , Dernóczi-Polyák Adrienn
Published: July 2022

A COVID-19 pandémia megjelenése és gyors terjedése gazdasági sokkhatást okozott, amely változást eredményezett az emberek mindennapi életének szerkezetében, valamint a fogyasztói magatartásban is. A világjárvány, az ebből fakadó korlátozások következtében megváltoztak a fogyasztók munkavégzéssel, kapcsolattartással, étkezéssel, kapcsolatos szokásai. A koronavírus-járvány miatt bevezetett társadalmi távolságtartás az élelmiszer-vásárlási szokások terén is változással járt. Tanulmányunkban megvizsgáltuk, milyen hatással van a COVID-19 két szomszédos ország – Magyarország és Szlovákia két régiójának élelmiszer-vásárlással kapcsolatos fogyasztói magatartására, valamint hogyan változtatta meg az élelmiszervásárlással kapcsolatos döntési tényezőket. Kutatásunk a pandémia második szakaszában, 2020 novemberében kezdődött és 2021 áprilisában fejeződött be. Online kérdőíves felmérést végeztünk levelezőlista, valamint a közösségi média felhasználásával. Hosszú távú trendek vizsgálata ebben a kezdeti időszakban még nem volt lehetséges, így csak a rövid távú hatásokra helyezzük a hangsúlyt. Délnyugat – Szlovákiában, konkrétan a pozsonyi – dunaszerdahelyi – komáromi régióban, Magyarországon pedig a Nyugat - dunántúli régióban (Győr – Moson - Sopron megye) végeztük a felmérést. Több jellegzetesség, magatartási eltérés volt fellelhető a két régió/ország között. Az online élelmiszer-vásárlás olyan általános trend, amely mindkét régióban tapasztalható volt, ezt a pandémiás helyzet némileg tovább fokozta. Kiderült, hogy az online élelmiszervásárlás még nem vált általánosan elterjedtté, a magyar, valamint a szlovák lakosság továbbra is ragaszkodik az élelmiszerek boltban történő vásárlásához. Eredményeink alapján látható, hogy bár nőtt az online vásárlások aránya, mégsem tűnik elegendőnek a válsághelyzet ahhoz, hogy a vásárlókban kialakult rutint, vagy a korlátokat, például az online vásárlással kapcsolatos bizonytalanságot, vagy az új, ezidáig nem ismert termék vásárlását teljesen feloldja. A pozitív tapasztalatokat biztosító változások azonban valószínűleg hosszabb ideig tartanak, különösen azok, amelyek a kényelem és a jólét által vezéreltek, mint például a digitális átvétel, az értékalapú vásárlás és a megnövekedett egészségtudatosság. Ez lehetőséget kínál a vállalatok számára, hogy innovatív, értékalapú és integrált termékeket vagy szolgáltatásokat kínáljanak a vásárlói igények kielégítésére.
JEL- kódok: D12, D91
The Mediating Effect of Social Connectedness on the Relationship between Intrusive rumination after Bereavement and Posttraumatic Growth
Authors:   The Association of Korea Counseling Psychology Education Welfare, KIM Du-Gil , SHIN Jae-Han
Published: July 2022

This study examined the mediating effect of social connectedness in the relationship betweenintrusive rumination after bereavement and posttraumatic growth. For this purpose, an onlinesurvey was conducted on 270 adults, and 257 questionnaires were used as final data except forthe questionnaires that were unfaithfully answered. The results of this study are as follows. First, intrusive rumination showed a significant negative correlation with social bond, positivecorrelation with posttraumatic growth, and social connectedness had a significant positivecorrelation with posttraumatic growth. Second, the most influential variable on posttraumaticgrowth were proved to intrusive rumination, and social connectedness and gender were foundto affect posttraumatic growth. This is interpreted that men rather than women, and the higherthe intrusive ruminum and social connectedness, the higher the posttraumatic growth. Third,social connectedness were proved to mediate in the relationship between intrusive ruminationand posttraumatic growth. This can be interpreted as the higher the social connectedness, thelower the intrusive ruminating and the higher the posttraumatic growth. Based on the results ofthis study, The imitations of the study and implications for the further research were discussed.
A Study on Effects of Parent Educational Experiences by Infants' Mothers on Parenting Stress and Child-rearing Attitude
Authors:   The Association of Korea Counseling Psychology Education Welfare, JONG Hye-Kyung
Published: July 2022

The purpose of this study is to investigate the effects of parent educational experiences by theinfants' mothers on the parenting stress and child-rearing attitude. For research object, this studywas to select the infants' mothers who had experienced offline form of parent educationprogram at least once, which has been actually applied in the educational institutes, not thespecific parent education program. To achieve this, this study was to execute the questionnaireas final research object of 298 infants' mothers had attended in the childcare center, located inDaegu Metropolitan City. From the result of this research above, it may be summed up asfollows. First, the parent educational experiences by the infants' mothers had significant negativecorrelation with the parenting stress. In addition, the parent educational experiences had nosignificant correlation with the affective child-rearing attitude. Whereas, there was significantcorrelation with the rejecting, autonomic, dominant child-rearing attitude. Second, the parenteducational experiences had significant effect on the rejecting, autonomic, and dominantchild-rearing attitude among the whole parenting stress by the infants' mothers and the subfieldsof child-rearing attitudes by the infants' mothers.