bluuebunny/crossref_metadata_2025 huggingface dataset:
Histological classification of canine and feline lymphoma using a modular approach based on deep learning and advanced image processing
Authors: Haghofer Andreas , Fuchs-Baumgartinger Andrea , Lipnik Karoline , Klopfleisch Robert , Aubreville Marc , Scharinger Josef , Weissenböck Herbert , Winkler Stephan M. , Bertram Christof A.
Published: November 2023

Histopathological examination of tissue samples is essential for identifying tumor malignancy and the diagnosis of different types of tumor. In the case of lymphoma classification, nuclear size of the neoplastic lymphocytes is one of the key features to differentiate the different subtypes. Based on the combination of artificial intelligence and advanced image processing, we provide a workflow for the classification of lymphoma with regards to their nuclear size (small, intermediate, and large). As the baseline for our workflow testing, we use a Unet++ model trained on histological images of canine lymphoma with individually labeled nuclei. As an alternative to the Unet++, we also used a publicly available pre-trained and unmodified instance segmentation model called Stardist to demonstrate that our modular classification workflow can be combined with different types of segmentation models if they can provide proper nuclei segmentation. Subsequent to nuclear segmentation, we optimize algorithmic parameters for accurate classification of nuclear size using a newly derived reference size and final image classification based on a pathologists-derived ground truth. Our image classification module achieves a classification accuracy of up to 92% on canine lymphoma data. Compared to the accuracy ranging from 66.67 to 84% achieved using measurements provided by three individual pathologists, our algorithm provides a higher accuracy level and reproducible results. Our workflow also demonstrates a high transferability to feline lymphoma, as shown by its accuracy of up to 84.21%, even though our workflow was not optimized for feline lymphoma images. By determining the nuclear size distribution in tumor areas, our workflow can assist pathologists in subtyping lymphoma based on the nuclei size and potentially improve reproducibility. Our proposed approach is modular and comprehensible, thus allowing adaptation for specific tasks and increasing the users’ trust in computer-assisted image classification.
The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer
Authors: Mahmoodi Chalbatani Ghanbar , Gharagouzloo Elahe , Malekraeisi Mohammad Amin , Azizi Paniz , Ebrahimi Amirabbas , Hamblin Michael R. , Mahmoodzadeh Habibollah , Elkord Eyad , Miri Seyed Rohollah , Sanati Mohammad Hossein , Panahi Bahman
Published: November 2023

Circular RNAs (circRNA) are known to function as competing endogenous RNA (ceRNA) in various cancers by regulating microRNAs (miRNA). However, in colorectal cancer (CRC), the precise pathological role of circ000240/miRNA/mRNA remains indeterminate. The expression level of hsa_circ_000240 was evaluated using qRT-PCR in matching pairs of CRC tumor and adjacent normal tissue samples in our laboratory. Then, to determine whether hsa_circ_000240 acted as a ceRNA in CRC, the linked miRNAs and gene targets were retrieved. Topological analysis of candidate genes using a network approach identified the most critical hub genes and subnetworks related to CRC disease. Microarray and bulk RNA sequencing analyses were utilized to comprehensively evaluate the expression levels of both miRNA and mRNA in CRC. Single-cell RNA-seq analysis was also used to evaluate the significant overall survival (OS) genes at the cellular level. ATAC-seq data provided insights into candidate genes' accessible chromatin regions. The research uncovered a considerable upregulation of hsa_circ_000240 in CRC tissues. Three miRNAs interacted with the target circRNA. One thousand six hundred eighty intersected genes regulated by three miRNAs were further identified, and the relevant functionality of identified neighbor genes highlighted their relevance to cancer. The topological analysis of the constructed network has identified 33 hub genes with notably high expression in CRC. Among these genes, eight, including CHEK1, CDC6, FANCI, GINS2, MAD2L1, ORC1, RACGAP1, and SMC4, have demonstrated a significant impact on overall survival. The utilization of single-cell RNA sequencing unequivocally corroborated the augmented expression levels of CDC6 and ORC1 in individuals with CRC, alongside their noteworthy connection with the infiltration of immune cells. ATAC-seq analyses revealed altered accessibility regions in Chr2, 4, and 12 for CDC6 and ORC1 high-expression. Correlation analysis of CDC6 and ORC1 further highlighted the association of candidate gene expression with exhaustion markers such as CTLA4, CD247, TIGIT, and CD244. The candidate genes exhibit a positive correlation with chromatin remodeling and histone acetylation. These epigenetic modifications play a significant role in influencing the cancer progression following expression of CDC6 and ORC1 in CRC. Additionally, results showed that the methylation rate of the promoter region of CDC6 was elevated in CRC disease, confirming the functional importance of CDC6 and their interaction with hsa_circ_000240 and associated ceRNA in CRC. In conclusion, this study highlights hsa_circ_000240's role as a ceRNA in CRC. It opens new avenues for further dissection of CDC6, ORC1, and underlying novel epigenetics and immunotherapy targets for CRC therapy.
Assessing the efficacy of jet dispenser versus direct syringe injection for calcium hydroxide paste placement in artificial root canals
Authors: Song Youngwook , Ham Hwichan , Lee WooCheol , Kim Ryan Jin Young
Published: November 2023

This study aimed to evaluate the efficacy of a novel jet dispenser (JD) for filling simulated straight and curved canals with calcium hydroxide (Ca(OH)2) paste by comparing the level of intracanal medicament with traditional direct syringe delivery. The Ca(OH)2 paste was delivered into the canals using either a direct syringe with binding tip and unbinding tip or a JD. The analysis of the ratio of the canal filled area (RCFA) in the coronal, middle, and apical thirds was conducted using the Kruskal–Wallis and Mann–Whitney U tests (α = 0.05). The JD resulted in a significantly higher RCFA of 1.00 in the middle and apical thirds in both the straight and curved canals than the direct syringe method (p < 0.001). Voids were frequently observed in the direct syringe group, whereas JD showed no voids within the filled area. In the direct syringe groups, the apical area was more readily filled in both canal types when the tip was bound (p < 0.001). The JD was found to be more effective in filling the entire canal space than the binding and unbinding conditions of the direct injection method, particularly in the apical area.
Performance of standardized cancer patient pathways in Sweden visualized using observational data and a state-transition model
Authors: Borg Sixten , Hörstedt Ann-Sofi , Carlsson Tobias , Nilbert Mef , Larsson Anna-Maria , Ohlsson Björn
Published: November 2023

Standardized Cancer Patient Pathways (CPPs) were introduced in Swedish healthcare starting in 2015 to improve diagnostics for patients with symptoms of cancer, patient satisfaction and equity of care between healthcare providers. An inclusion target and a time target were set. Our primary aim was to visualize the patient population going through CPPs, in terms of investigation time and indications of the various outcomes including cancer diagnoses. Our secondary aims were to examine if targets were met, and to examine frequencies of undetected cancer. We collected data from 19,204 patients starting in a CPP, and 7895 patients diagnosed with cancer in 2018 in a region of Sweden. A state transition model was developed and used as analytical framework, and patients were mapped over time in the states of the model. Visualization of the patient-flow through the model illustrates speed of investigation, time to treatment, frequencies of detected and undetected cancer. Twelve CPPs out of 28 met the inclusion target, five met the time target. After suspicion of cancer rejected, 0.8% of patients were diagnosed with the primarily suspected cancer, 1.0% with another cancer. In patients not meeting the criteria for well-founded suspicion less than 3% were later diagnosed with cancer. The visualization of the patient flow into and through standardized cancer patient pathways illustrates investigation time, events occurring and outcomes. The use of standardized cancer patient pathways detects cancer efficiently.
Erythropoietin regulates developmental myelination in the brain stimulating postnatal oligodendrocyte maturation
Authors: Muttathukunnel Paola , Wälti Michael , Aboouf Mostafa A. , Köster-Hegmann Christina , Haenggi Tatjana , Gassmann Max , Pannzanelli Patrizia , Fritschy Jean-Marc , Schneider Gasser Edith M.
Published: November 2023

Myelination is a process tightly regulated by a variety of neurotrophic factors. Here, we show—by analyzing two transgenic mouse lines, one overexpressing EPO selectively in the brain Tg21(PDGFB-rhEPO) and another with targeted removal of EPO receptors (EPORs) from oligodendrocyte progenitor cells (OPC)s (Sox10-cre;EpoRfx/fx mice)—a key function for EPO in regulating developmental brain myelination. Overexpression of EPO resulted in faster postnatal brain growth and myelination, an increased number of myelinating oligodendrocytes, faster axonal myelin ensheathment, and improved motor coordination. Conversely, targeted ablation of EPORs from OPCs reduced the number of mature oligodendrocytes and impaired motor coordination during the second postnatal week. Furthermore, we found that EPORs are transiently expressed in the subventricular zone (SVZ) during the second postnatal week and EPO increases the postnatal expression of essential oligodendrocyte pro-differentiation and pro-maturation (Nkx6.2 and Myrf) transcripts, and the Nfatc2/calcineurin pathway. In contrast, ablation of EPORs from OPCs inactivated the Erk1/2 pathway and reduced the postnatal expression of the transcripts. Our results reveal developmental time windows in which EPO therapies could be highly effective for stimulating oligodendrocyte maturation and myelination.
Accurate emulation of steady-state and dynamic performances of PEM fuel cells using simplified models
Authors: Ashraf Hossam , Elkholy Mahmoud M. , Abdellatif Sameh O. , El‑Fergany Attia A.
Published: November 2023

The current effort addresses a novel attempt to extract the seven ungiven parameters of PEMFCs stack. The sum of squared deviations (SSDs) among the measured and the relevant model-based calculated datasets is adopted to define the cost function. A Kepler Optimization Algorithm (KOA) is employed to decide the best values of these parameters within viable ranges. Initially, the KOA-based methodology is applied to assess the steady-state performance for four practical study cases under several operating conditions. The results of the KOA are appraised against four newly challenging algorithms and the other recently reported optimizers in the literature under fair comparisons, to prove its superiority. Particularly, the minimum values of the SSDs for Ballard Mark, BCS 0.5 kW, NedStack PS6, and Temasek 1 kW PEMFCs stacks are 0.810578 V2, 0.0116952 V2, 2.10847 V2, and 0.590467 V2, respectively. Furthermore, the performance measures are evaluated on various metrics. Lastly, a simplified trial to upgrade Amphlett’s model to include the PEMFCs’ electrical dynamic response is introduced. The KOA appears to be viable and may be extended in real-time conditions according to the presented scenarios (steady-state and transient conditions).
Ultrastructure of noise-induced cochlear synaptopathy
Authors: Moverman Daniel J. , Liberman Leslie D. , Kraemer Stephan , Corfas Gabriel , Liberman M. Charles
Published: November 2023

Acoustic overexposure can eliminate synapses between inner hair cells (IHCs) and auditory nerve fibers (ANFs), even if hair-cell function recovers. This synaptopathy has been extensively studied by confocal microscopy, however, understanding the nature and sequence of damage requires ultrastructural analysis. Here, we used focused ion-beam scanning electron microscopy to mill, image, segment and reconstruct ANF terminals in mice, 1 day and 1 week after synaptopathic exposure (8–16 kHz, 98 dB SPL). At both survivals, ANF terminals were normal in number, but 62% and 53%, respectively, lacked normal synaptic specializations. Most non-synapsing fibers (57% and 48% at 1 day and 1 week) remained in contact with an IHC and contained healthy-looking organelles. ANFs showed a transient increase in mitochondrial content (51%) and efferent innervation (34%) at 1 day. Fibers maintaining synaptic connections showed hypertrophy of pre-synaptic ribbons at both 1 day and 1 week. Non-synaptic fibers were lower in mitochondrial content and typically on the modiolar side of the IHC, where ANFs with high-thresholds and low spontaneous rates are normally found. Even 1 week post-exposure, many ANF terminals remained in IHC contact despite loss of synaptic specializations, thus, regeneration efforts at early post-exposure times should concentrate on synaptogenesis rather than neurite extension.
Mitigation of biogenic methanethiol using bacteriophages in synthetic wastewater augmented with Pseudomonas putida
Authors: Sarat Niti , Salim Amrita , Pal Sanjay , Subhash Suja , Prasad Megha , Nair Bipin G. , Madhavan Ajith
Published: November 2023

Wastewater malodour is the proverbial ‘elephant in the room’ notwithstanding its severe implications on sanitation, health, and hygiene. The predominant malodorous compounds associated with wastewater treatment plants and toilets are volatile organic compounds, such as hydrogen sulphide, ammonia, methanethiol, and organic acids. Among them, methanethiol warrants more attention owing to its relatively low olfactory threshold and associated cytotoxicity. This requires an efficient odour-abatement method since conventional techniques are either cost-prohibitive or leave recalcitrant byproducts. Bacteriophage-based methodology holds promise, and the described work explores the potential. In this study, a non-lysogenous Pseudomonas putida strain is used as a model organism that produces methanethiol in the presence of methionine. Two double-stranded DNA phages of genome sizes > 10 Kb were isolated from sewage. ɸPh_PP01 and ɸPh_PP02 were stable at suboptimal pH, temperature, and at 10% chloroform. Moreover, they showed adsorption efficiencies of 53% and 89% in 12 min and burst sizes of 507 ± 187 and 105 ± 7 virions per cell, respectively. In augmented synthetic wastewater, ɸPh_PP01 and ɸPh_PP02 reduced methanethiol production by 52% and 47%, respectively, with the concomitant reduction in P. putida by 3 logs in 6 h. On extension of the study in P. putida spiked-sewage sample, maximum reduction in methanethiol production was achieved in 3 h, with 49% and 48% for ɸPh_PP01 and ɸPh_PP02, respectively. But at 6 h, efficiency reduced to 36% with both the phages. The study clearly demonstrates the potential of phages as biocontrol agents in the reduction of malodour in wastewater.
Selective dopamine D2 receptor deletion from Nkx6.2 expressing cells causes impaired cognitive, motivation and anxiety phenotypes in mice
Authors: Bechelli Lucila , Tomasella Eugenia , Cardoso Sofia Lopez , Belmonte Martina , Gelman Diego M.
Published: November 2023

Abnormal dopamine neurotransmission is a common trait of some psychiatric diseases, like schizophrenia or bipolar disorder. Excessive dopaminergic tone in subcortical brain regions is associated with psychotic episodes, while reduced prefrontal dopaminergic activity is associated with impaired cognitive performance and reduced motivation, among other symptoms. Inhibitory interneurons expressing the calcium binding protein parvalbumin are particularly affected in both schizophrenia and bipolar disorder, as they set a fine-tuned physiological inhibitory/excitatory balance. Parvalbumin and somatostatin interneuron subtypes, are born from the medial ganglionic eminence and require the sequential expression of specific transcription factors for their specification, such as Nkx6.2. Here, we aimed at characterizing in detail interneuron subtypes derived from Nkx6.2 expressing progenitors by the generation of an Nkx6.2 Cre transgenic mouse line. We show that Nkx6.2 specifies over a third part of the total population of cortical somatostatin interneurons, preferentially at early developmental time points, whereas at late developmental stages, Nkx6.2 expressing progenitors shift to parvalbumin interneuron specification. Dopamine D2 receptor deletion from Nkx6.2 expressing progenitors causes abnormal phenotypes restricted to cognitive, motivation and anxiety domains. Our results show that Nkx6.2 have the potential to specify both somatostatin and parvalbumin interneurons in an opposite timed program and that DRD2 expression is required in Nkx6.2 expressing progenitors to avoid impaired phenotypes commonly associated to the pathophysiology of psychiatric diseases.
Machine learning framework for precise localization of bleached corals using bag-of-hybrid visual feature classification
Authors: Fawad  , Ahmad Iftikhar , Ullah Arif , Choi Wooyeol
Published: November 2023

Corals are sessile invertebrates living underwater in colorful structures known as reefs. Unfortunately, coral’s temperature sensitivity is causing color bleaching, which hosts organisms that are crucial and consequently affect marine pharmacognosy. To address this problem, many researchers are developing cures and treatment procedures to restore bleached corals. However, before the cure, the researchers need to precisely localize the bleached corals in the Great Barrier Reef. The researchers have developed various visual classification frameworks to localize bleached corals. However, the performance of those techniques degrades with variations in illumination, orientation, scale, and view angle. In this paper, we develop highly noise-robust and invariant robust localization using bag-of-hybrid visual features (RL-BoHVF) for bleached corals by employing the AlexNet DNN and ColorTexture handcrafted by raw features. It is observed that the overall dimension is reduced by using the bag-of-feature method while achieving a classification accuracy of 96.20% on the balanced dataset collected from the Great Barrier Reef of Australia. Furthermore, the localization performance of the proposed model was evaluated on 342 images, which include both train and test segments. The model achieved superior performance compared to other standalone and hybrid DNN and handcrafted models reported in the literature.
Screening for a practical method to monitor the status of patients with metastatic bladder cancer at the circulating cell-gene level
Authors: Ogura Ryota , Ito Saya , Ueda Takashi , Gabata Yusuke , Sako Satoshi , Inoue Yuta , Yamada Takeshi , Konishi Hirotaka , Fujihara Atsuko , Ukimura Osamu
Published: November 2023

Identifying a novel method to monitor metastatic bladder cancer status at the cell-gene level could lead to earlier appropriate therapeutic intervention and better outcomes. In this study, we evaluated a practical method to monitor the cancer status at the circulating cell-gene level before and after treatment in fourteen patients with metastatic bladder cancer who were indicated for systemic drug therapy. Patients were assessed via imaging before and after drug treatment, and cell-free DNA (cfDNA) analysis was performed to detect three parameters: cfDNA level, ERRB2 gene copy numbers, and telomerase reverse transcriptase (TERT) gene mutations. We hypothesized that decreased cfDNA levels, a normal copy number of ERB-B2 receptor tyrosine kinase 2 (ERBB2), and the absence of the TERT C228T mutation indicate cancer suppression. We found that a > 1.8-fold increase in cfDNA levels, increased copy number of ERBB2, or the existence of the TERT C228T mutation indicated disease progression. Stable cfDNA levels, normal ERBB2 copy number, and the absence of TERT C228T mutations indicate a stable cancer status. Collectively, our results show that the combination of cfDNA concentration, TERT mutation, and ERBB2 copy number may be useful for determining the efficacy of drug therapy in patients with metastatic bladder cancer.
The correlation between GFR and unit renal volume in infants with hydronephrosis measured by two imaging methods
Authors: Guo Ke , Zhao Deshan
Published: November 2023

The purpose of this study was to investigate the correlation between GFR and unit renal volume in infants with congenital hydronephrosis measured by 99mTc-DMSA static renal imaging and ultrasonography. According to the classification of hydronephrosis, 38 infants aged 0–12 months with congenital hydronephrosis were divided into six groups: healthy kidney groups, mild hydronephrosis groups, and severe hydronephrosis groups. Within one week, all patients underwent ultrasound, diuretic dynamic renal imaging, static renal imaging and lateral imagings of both kidneys after static renal imaging respectively. Pediatric renal volume was calculated using the improved formula length × width × thickness × 0.674, and then the renal function in per unit volume (GFR/unit volume, ml/cm3) was obtained. All statistical analysis was done with SPSS Statistics version 24.0. The renal function in per unit volume was a minimum of 1.62 ml/cm3 in left healthy kidney in static renal imaging, but the renal function in per unit volume was a maximum value of 2.20 ml/cm3 in right healthy kidney in ultrasonography. There was a strong positive correlation observed between GFR and renal volume in left healthy kidney group and left and right kidneys with mild hydronephrosis groups (r = 0.865, r = 0.872, r = 0.822). A moderate positive correlation was found between GFR and renal volume in right healthy kidney group and left and right kidneys wih severe hydronephrosis groups (r = 0.783, r = 0.542, r = 0.798). GFR in per unit volume ranged from 1.62 to 2.20 ml/cm3 in healthy kidney, and was significantly higher in right kidney as compared to in left kidney, and also decreased with the progression of hydronephrosis.
A systematic review of the impacts of post-harvest handling on provitamin A, iron and zinc retention in seven biofortified crops
Authors: Huey Samantha L. , Konieczynski Elsa M. , Mehta Neel H. , Krisher Jesse T. , Bhargava Arini , Friesen Valerie M. , Mbuya Mduduzi N. N. , Monterrosa Eva C. , Nyangaresi Annette M. , Mehta Saurabh
Published: November 2023

Post-harvest handling can affect micronutrient retention in biofortified crops through to the point of consumption. Here we conduct a systematic review identifying 67 articles examining the retention of micronutrients in conventionally bred biofortified maize, orange sweet potato, cassava, pearl millet, rice, beans and wheat. Provitamin A crops maintain high amounts compared with non-biofortified counterparts. Iron and zinc crops have more variability in micronutrient retention dependent on processing method; for maximum iron and zinc content, whole grain product consumption such as whole wheat flour or only slightly milled brown rice is beneficial. We offer preliminary suggestions for households, regulatory bodies and programme implementers to increase consumer awareness on best practices for preparing crops to maximize micronutrient content, while highlighting gaps in the literature. Our online, interactive Micronutrient Retention Dashboard (https://www.cpnh.cornell.edu/mn-retention-db) offers an at-a-glance view of the compiled minimum and maximum retention found, organized by processing method.
The cyclization/rearrangement of α-hydroxy ketones with trifluoromethyl N-acylhydrazones to synthesize multi-substituted trifluoromethyloxazolines
Authors: Wang Junjiao , Shang Yongwei , Zhao Xiujuan , Cui Zhenli , Li Yang , Wang Ke-Hu , Huang Danfeng , Hu Yulai , Wang Na , Feng Lei
Published: November 2023

A highly efficient and metal-free [3+2] cyclization/rearrangement reaction toward the synthesis of multisubstituted trifluoromethyloxazolines from α-hydroxyketones and trifluoromethyl N-acylhydrazones has been developed.
Mechanochemical reduction of clay minerals to porous silicon nanoflakes for high-performance lithium-ion battery anodes
Authors: Chen Qingze , Wei Shoushu , Zhu Runliang , Du Jing , Xie Jieyang , Huang Haiming , Zhu Jianxi , Guo Zhengxiao
Published: November 2023

We reported a facile, scalable, and cost-effective mechanochemical reduction strategy to synthesize hierarchically porous silicon nanoflakes with enhanced electrochemical performance from clay minerals.
Photoinduced reductive Reformatsky reaction of α-haloesters and aldehydes or ketones by cooperative dual-metal catalysis
Authors: Chen Qi-Long , Mao Le , Pan Yi-Fan , Cai Heng , Zhang Xiao-Ming , Zhang Fu-Min , Ma Ai-Jun , Peng Jin-Bao , Tu Yong-Qiang
Published: November 2023

Combination of iron- and photocatalysis enables the development of a reductive Reformatsky reaction, providing a catalytic synthetic method to β-hydroxy esters from α-haloesters and aldehydes or ketones.
Assembly and optically triggered disassembly of lipid–DNA origami fibers
Authors: Julin Sofia , Best Nadine , Anaya-Plaza Eduardo , Enlund Eeva , Linko Veikko , Kostiainen Mauri A.
Published: November 2023

DNA origami and a photosensitive lipid are co-assembled into ordered fibers, which can be disassembled through UV-A light exposure.
Optimizing milling and sintering parameters for mild synthesis of highly conductive Li5.5PS4.5Cl1.5 solid electrolyte
Authors: Lei Tianyu , Peng Linfeng , Liao Cong , Chen Shuai , Cheng Shijie , Xie Jia
Published: November 2023

Under milder conditions, Li5.5PS4.5Cl1.5 with ionic conductivity of 7.92 mS cm−1 and excellent electrochemical properties can be obtained after 400 rpm-ball milling followed by sintering at 400 °C.
Intramolecular C–N bond activation by a transient boryl anion
Authors: Nahon Emily E. , Nelmes Gareth R. , Brothers Penelope J. , Hicks Jamie
Published: November 2023

Electrophilic or nucleophilic? Reduction of a bulky boron bromide with lithium leads to C–N bond cleavage though a nucleophilic boryl anion. In contrast, reaction with an anionic iron carbonyl salt leads to cooperative reduction of CO.
Enhancement of cell membrane permeability by using charged nanoparticles and a weak external electric field
Authors: Nakamura Hideya , Okamura Takumi , Tajima Masaya , Kawano Ryuji , Yamaji Misa , Ohsaki Shuji , Watano Satoru
Published: November 2023

Because the cell membrane is the main barrier of intracellular delivery, it is important to facilitate and control the translocation of extracellular compounds across it.
Influence of ligand variation on the deactivation process of metal-to-ligand charge transfer excited states in quadruply bonded dimolybdenum complexes
Authors: Shi Yuqing , Li Juanjuan , Cui Can , Wu Guanzhi , Cheng Tao
Published: November 2023

To explore the dynamics of metal-to-ligand charge transfer (MLCT) excited states involving covalently bonded dimetal units, a series of quadruply bonded dimolybdenum (Mo2) complexes were synthesized and characterized.
Exploring the reaction kinetics of methyl formate + NO2: implication for ignition behavior of methyl formate/NO2 mixtures
Authors: Zhang Yiran , Wang Sihao , Zhang Zhenpeng , Fu Li , Ning Hongbo , Zhao H. Y.
Published: November 2023

The importance of reaction kinetics for the title reaction in predicting the ignition behavior of MF/NO2 mixtures is demonstrated.
Oxidation kinetic mechanism of n-decane under high temperature and pressure: a first-principles molecular dynamics study
Authors: Zhang Teng , Xia Wenbo , Fan Wei , Chen Lang , Chen Jun
Published: November 2023

The C–C bond dissociation reactions play key roles in the combustion kinetics of C10H22 under high pressure.
Exploiting click-chemistry: backbone post-functionalisation of homoleptic gold(i) 1,2,3-triazole-5-ylidene complexes
Authors: Richter Leon F. , Marques Fernanda , Correia João D. G. , Pöthig Alexander , Kühn Fritz E.
Published: November 2023

A novel, highly active homoleptic azide-functionalised Au(i) bis-1,2,3-triazole-5-ylidene complex is synthesised and easily modified using click-chemistry protocols, while maintaining high antiproliferative activity in human cancer cells.
Nature-derived gelatin-based antifungal nanotherapeutics for combatting Candida albicans biofilms
Authors: Nabawy Ahmed , Makabenta Jessa Marie , Park Jungmi , Huang Rui , Nayar Varun , Patel Robin , Rotello Vincent M.
Published: November 2023

Biodegradable and all-natural gelatin-based nanoemulsions encapsulate and stabilize antifungal essential oils to provide efficient penetration and eradication of drug-resistant fungal biofilms without resistance generation.
Nutrikinetics and urinary excretion of phenolic compounds after a 16-week supplementation with a flavanone-rich ingredient
Authors: Muralidharan Jananee , Romain Cindy , Bresciani Letizia , Mena Pedro , Angelino Donato , Del Rio Daniele , Chung Linda H. , Alcaraz Pedro E. , Cases Julien
Published: November 2023

Metabolic fate of polyphenols in an acute and chronic setup.
Lactobacillus rhamnosus Probio-M9 alleviates OVA-sensitized food allergy through modulating gut microbiota and its metabolism
Authors: Shi Jialu , Dong Pengfei , Liu Cheng , Xu Yan , Zheng Mingzhu , Cheng Lei , Wang Jin , Raghavan Vijaya
Published: November 2023

Human milk probiotics M9 affect the microbiome and immune status, which could improve symptoms of food allergy.
Use of dipyridyldithiocarbonate (DPDTC) as an environmentally responsible reagent leading to esters and thioesters under green chemistry conditions
Authors: Freiberg Kaitlyn M. , Ghiglietti Erika , Scurria Matthew , Lipshutz Bruce H.
Published: November 2023

A new, green esterification and thioesterification method has been developed based on the intermediacy of in situ-generated 2-thiopyridine esters derived from dipyridyldithiocarbamate (DPDTC).
A multifunctional lignin-based composite ultra-adhesive for wood processing
Authors: Zhan Boxiang , Zhang Long , Deng Yongqi , Yan Lifeng
Published: November 2023

A high-strength lignin-based composite adhesive has been prepared by the reaction of lignin and furfural in a green DES, and the adhesive has excellent flame retardance, thermal insulating, and photothermal properties.
Discovery of a dual-acting inhibitor of interleukin-1β and STATs for the treatment of inflammatory bowel disease
Authors: Cai Haowei , Liu Zhuorong , Sun Ping , Zhou Yinghua , Yan Yuyun , Luo Yiming , Zhang Xiuxiu , Wu Ruiwen , Liang Xiangting , Wu Dan , Hu Wenhui , Yang Zhongjin
Published: November 2023

Hybridization of active fragments led to the NLRP3-based dual inhibitor 10v, which exhibited potent inhibitory activity against the IL-1β and STAT pathway.
Photo-enhanced dehydrogenation of formic acid on Pd-based hybrid plasmonic nanostructures
Authors: Zhu Jiannan , Dai Jiawei , Xu You , Liu Xiaoling , Wang Zhengyun , Liu Hongfang , Li Guangfang
Published: November 2023

Based on recent advances in plasmon-enhanced formic acid dehydrogenation, this minireview discusses the geometry-dependent optical and electronic site tuning in plasmon catalysis, illustrates the plasmon energy flow mechanism through typical research.
Advanced graphene-based (photo & electro) catalysts for sustainable & clean energy technologies
Authors: Akhter Raheela , Hussain Shokat , Maktedar Shrikant S.
Published: November 2023

Due to the wide range of uses of graphene and its composites in electrocatalysis and photocatalysis, there has been a lot of interest in these materials.
A metastable small organic molecule for secure memory devices
Authors: Wang Hong-Liang , Du Yu-Ting , Zhang Xiao-Juan , Ren Hai-Xian , Qin Lu , Luo Xiao-Bo , Gu Pei-Yang , Xu Lingyun , Zhou Shi-Yuan
Published: November 2023

A PFTCM molecule with strong donor–acceptor structure was synthesized for data storage and secure memory devices.
A DFT study of NHC-catalyzed reactions of [3+3] annulations of 2-bromoenals and thioamides: mechanisms and regio- and stereoselectivities
Authors: Li Yan , Geng Lina , Song Zhiyi , Zhang Zhiqiang
Published: November 2023

The mechanisms and regio- and stereoselectivities of NHC-catalyzed [3+3] annulations of 2-bromoenals and thioamides are investigated.
Template-free generation and integration of functional 1D magnetic nanostructures
Authors: Sedrpooshan Mehran , Bulbucan Claudiu , Ternero Pau , Maltoni Pierfrancesco , Preger Calle , Finizio Simone , Watts Benjamin , Peddis Davide , Burke Adam M. , Messing Maria E. , Westerström Rasmus
Published: November 2023

This work reports on a novel template-free technique for producing isolated 1D magnetic nanochains and nanowires directly onto substrates and device architectures by directed self-assembly of gas-phase-generated nanoparticles.
An innovative method for controlled synthesis of bicomponent monolayer films obtained by reduction of diazonium
Authors: Billon Julien , Omelchuk Anna , Shkirskiy Viacheslav , Dabos-Seignon Sylvie , Alévêque Olivier , Levillain Eric , Breton Tony , Gautier Christelle
Published: November 2023

This study presents a novel method based on the electrochemical co-reduction of two aryldiazonium salts, enabling the synthesis of controlled two-component monolayer thin films on carbon in a single step.
Targeted delivery of LXR-agonists to atherosclerotic lesions mediated by polydiacetylene micelles
Authors: Jamgotchian Lucie , Devel Laurent , Thai Robert , Poupel Lucie , Huby Thierry , Gautier Emmanuel , Le Goff Wilfried , Lesnik Philippe , Gravel Edmond , Doris Eric
Published: November 2023

We report the development of compact and stabilized micelles incorporating a synthetic LXR agonist prodrug for the passive targeting of atherosclerotic lesions and therapeutic intervention.
A synthetic route to artificial chiral α-amino acids featuring a 3,4-dihydroisoquinolone core through a Rh(iii)-catalyzed functionalization of allyl groups in chiral Ni(ii) complexes
Authors: Arsenov Mikhail A. , Stoletova Nadezhda V. , Smol'yakov Alexander F. , Savel'yeva Tat'yana F. , Maleev Victor I. , Loginov Dmitry A. , Larionov Vladimir A.
Published: November 2023

The first asymmetric synthetic route to artificial α-amino acids with a 3,4-dihydroisoquinolone skeleton was elaborated via a straightforward Rh(iii)-catalyzed C–H activation/annulation reaction.
The hamburger-shape photocatalyst: thioxanthone-based chiral [2.2]paracyclophane for enantioselective visible-light photocatalysis of 3-methylquinoxalin-2(1H)-one and styrenes
Authors: Huo Shou-Chih , Indurmuddam Ranadheer Reddy , Hong Bor-Cherng , Lu Chuan-Fu , Chien Su-Ying
Published: November 2023

A new thioxanthone-based photocatalyst with a [2.2]paracyclophane skeleton and planar chirality has been developed and utilized in the visible light-mediated enantioselective aza Patern–Büchi reaction.
Heterogeneous CoS2/MS2 microspheres for an efficient oxygen evolution reaction
Authors: Wang Xiaoqu , Wang Limin , Kohila Rani Karuppasamy , Peng Xinglan , Ning Yu , Liu Xiaotian , Fan Youjun , Chen Du-Hong , Chen Wei
Published: November 2023

Heterogeneous CoS2/MS2 microspheres lower the overpotential of the oxygen evolution reaction.
Dinitrogen activation by a titanium hydride complex supported by 2-butene ligand
Authors: Shi Xianghui , Zhang Yongliang , Zhong Mingdong , Feng Rui , Chen Yuanjin , Yu Lei , Wu Yue , Wei Junnian , Xi Zhenfeng
Published: November 2023

The activation of dinitrogen by a titanium hydride complex with two bridging hydrides located between metal Ti and Li was investigated.
Solution-gel-based surface modification of LiNi0.5Mn1.5O4−δ with amorphous Li–Ti–O coating
Authors: Ulu Okudur Fulya , Batuk Maria , Hadermann Joke , Safari Mohammadhosein , De Sloovere Dries , Kumar Mylavarapu Satish , Joos Bjorn , D'Haen Jan , Van Bael Marlies K. , Hardy An
Published: November 2023

LNMO powder surface was modified with amorphous Li–Ti–O. Increase in electrochemically active surface area, as well as improved HF-scavenging enhanced its electrochemical performance.
Expression of concern: Cobalt metal–organic framework-based ZIF-67 for the trace determination of herbicide molinate by ion mobility spectrometry: investigation of different morphologies
Authors: Davoodi Mehdi , Davar Fatemeh , Rezayat Mohammad R. , Jafari Mohammad T. , Shalan Ahmed Esmail
Published: November 2023

Expression of concern for ‘Cobalt metal–organic framework-based ZIF-67 for the trace determination of herbicide molinate by ion mobility spectrometry: investigation of different morphologies’ by Mehdi Davoodi et al., RSC Adv., 2021, 11, 2643–2655, DOI: https://doi.org/10.1039/D0RA09298C.
Electron transport through supercrystals of atomically precise gold nanoclusters: a thermal bi-stability effect
Authors: Higaki Tatsuya , Russell Jake C. , Paley Daniel W. , Roy Xavier , Jin Rongchao
Published: November 2023

Supercrystals assembled from atomically precise gold nanoclusters exhibit a thermally responsive transition in charge transport.
Regulation of heterogeneous electron transfer reactivity by defect engineering through electrochemically induced brominating addition
Authors: Zeng Lanping , Han Lianhuan , Nan Wenjing , Song Weiying , Luo Shiyi , Wu Yuan-Fei , Su Jian-Jia , Zhan Dongping
Published: November 2023

The heterogeneous electron transfer reactivity of single layer graphene can be regulated by defect engineering via electrochemically induced bromination which offers new possibilities for leveraging graphene in various electrochemical applications.
Selective C–O bond cleavage in diphenyl ether via catalytic transfer hydrogenolysis over Ru-decorated nanocrystalline H-ZSM-5
Authors: Kumar Atul , Srivastava Rajendra
Published: November 2023

Ru NPs incorporated nanocrystalline HZSM-5 selectively break C–O bonds in diphenyl ether, a lignin model compound, via a sustainable catalytic transfer hydrogenolysis pathway, transforming it into valuable fuels and fuel additives.
Developmental Trajectory of the Frequency-Following Response During the First 6 Months of Life
Authors: Ribas-Prats Teresa , Cordero Gaël , Lip-Sosa Diana Lucia , Arenillas-Alcón Sonia , Costa-Faidella Jordi , Gómez-Roig María Dolores , Escera Carles
Published: November 2023

Purpose:

The aim of the present study is to characterize the maturational changes during the first 6 months of life in the neural encoding of two speech sound features relevant for early language acquisition: the stimulus fundamental frequency (
f
o
), related to stimulus pitch, and the vowel formant composition, particularly F
1
. The frequency-following response (FFR) was used as a snapshot into the neural encoding of these two stimulus attributes.

Method:

FFRs to a consonant–vowel stimulus /da/ were retrieved from electroencephalographic recordings in a sample of 80 healthy infants (45 at birth and 35 at the age of 1 month). Thirty-two infants (16 recorded at birth and 16 recorded at 1 month) returned for a second recording at 6 months of age.

Results:

Stimulus
f
o
and F
1
encoding showed improvements from birth to 6 months of age. Most remarkably, a significant improvement in the F
1
neural encoding was observed during the first month of life.

Conclusion:

Our results highlight the rapid and sustained maturation of the basic neural machinery necessary for the phoneme discrimination ability during the first 6 months of age.
Growth parameters ofChanna striatain Musi River, Bengkulu and South Sumatra Province
Authors: Anggraeni Dian Pamularsih , Wulandari Tuah Nanda Merlia , Ali Muhammad , Fatah Khoirul , Makri  , Makmur Safran , Aida Siti Nurul
Published: November 2023

Due to the demand for striped snakeheads (Channa striata) as raw material for making exceptional Palembang foods such as corkscrews, fish cake “Pempek”, and crackers, the rate of exploitation becoming high and triggering continuous fishing by the fishermen. Information connected to the stock of striped snakehead is not widely known. This research intends to examine the growth parameters of striped snakehead. The research was held in March, April, June to September 2018 in the Musi River, South Sumatra Province. Fish tackle, including different-sized gill nets and nets, was used to gather fish samples from fishermen. The information acquired includes the rate of exploitation, the rate of mortality from natural or fishingrelated causes, and the rate of total mortality. The calculation results show the rate of total mortality (Z) = 0.95, the rate of natural mortality (M) = 0.67, death due to capture (F) = 0.28, and the rate of exploitation (E) = 0.29 every year.
Heavy metals contamination in water, sediment, and fish in Situ Gunung Putri, Bogor, Indonesia
Authors: Aristawidya Mira , Effendi Hefni , Damar Ario , Yustiawati
Published: November 2023

Situ Gunung Putri is one of the urban lakes in Bogor Regency, Indonesia, which has been affected by population growth and industrialization, making these waters vulnerable to heavy metals contamination. This study aimed to determine the distribution and concentration of heavy metals in Situ Gunung Putri in the water, sediment, and fish. Heavy metals were analyzed using the acid destruction method referring to APHA Standard Methods, while data analysis consisted of descriptive analysis and Bioaccumulation Factor (BAF). Heavy metals concentration in surface water still meets the tolerable value of national quality standards, except for Pb. Meanwhile, heavy metals concentration in sediments has exceeded the Threshold Effect Level (TEL) and Probability Effect Level (PEL) of Canadian Freshwater Sediment Guidelines, and the highest concentrations for all metals found at station 1, located near the inlet from the industries. Metals analysis in fish flesh showed that they exceeded the permitted threshold, except for Cu. Several types of heavy metals show a negative correlation between fish body length and heavy metal concentrations. The BAF value in fish flesh shows results of >1000 for Cu and Zn metals.
Effect of different amounts of green mussel shell (Perna viridis) on the reproductive and spawning rate of the endemic Ajamaru Lake rainbowfish (Melanotaenia ajamaruensis Allen & Cross, 1980)
Authors: Kadarini Tutik , Suryati Amida , Mundayana Yuani , Wibowo Arik Hari , Novita Hanna Gisella , Kusdiarti  , Syam Amran Ronny
Published: November 2023

Ajamaru Rainbowfish (Melanotaenia ajamaruensis) is an endemic species of Lake Ajamaru, Papua, Indonesia, and inhabits water at a pH of 6.5 – 8.5. However, the reproductive rate of the Ajamaru rainbowfish and what factors influence it are not widely known. This study aimed to determine the reproductive capacity of the Ajamaru Rainbowfish. A pair of male and female fish with a ratio of 1:1 were used during the study. The pH of the water was increased by adding different amounts of Perna viridis green mussel shells. The dosages used for the treatments were 0, 2, 4, 6, and 8 g/l, with three replications for 30 days in the Jakarta Technical University of Fisheries Laboratory. Fish spawned naturally every two days for 30 days. Fish fed blood worms 5% of their weight. The parameters observed were the calcium content of mussel shells and water media, water quality (pH, alkalinity, temperature, and oxygen), spawning frequency, number of eggs, fertilization rate, and hatching rate. The results showed that 2 g/l green mussel shells gave the highest value at 15 spawning times, fertilization rate/FR was 97.16%, hatching rate/HR (%) was 97.93, and 537.67 ± 89.37 larvae. Increase in pH 7.42-7.7 from 6.45-6.47.
Some indicators for assessing the stock of redtail scad (Decapterus kurroidesBleeker, 1855) in Palabuhanratu Waters, West Java, Indonesia
Authors: Chodrijah Umi , Tirtadanu  , Prihatiningsih  , Fauzi Muh. , Wagiyo Karsono , Restiangsih Yoke Hany
Published: November 2023

The redtail scad fish (Decapterus kurroides, Bleeker 1855) is a dominant small pelagic fish that has high economic value. Therefore, it is important to maintain and manage redtail scad resources in an efficient and sustainable approach. This study was carried out in the Palabuhanratu Fishing Port, West Java in 2019. The objective of this study was to assess the stock of redtail scad as a basis for their sustainable management. The findings revealed that the distribution of the 3076 samples' total length ranged from 14.7 to 45.0 cm, with an average of 25.69 cm. The growth pattern was positively allometric. The sex ratio between males and females is unbalanced, and the most significant proportion of mature females was found in July. The bottom longline and gillnet catch a larger size of redtail scad than the handline. A legal size of 26 cm was recommended for the optimal size of the redtail scad. The asymptotic length (L∞) and growth rate (K) were 45.43 cm and 0.61 year-1, respectively. The exploitation rate (E) was 0.52 year-1, indicating that a fisheries status leads to an overfishing condition.
A review of ocean health index research: Towards the development of its dynamic model in Indonesia
Authors: Rintaka Wingking Era , Kurniawan Fery , Radiarta I.N. , Nurjaya I.W. , Bengen Dietriech G.
Published: November 2023

Many studies use Ocean Health Index (OHI) calculations on global and regional scales. There was still a dearth of research that used a framework to examine the local level. Meanwhile, policies to achieve environmental management objectives for marine ecosystems will be more applicable locally. This study aims to discover the most appropriate benchmark for OHI calculations on a local scale, namely by reviewing manuscripts from 2012 to 2022 based on geography, publication field, resolution, and data sources. The data were used to determine benchmarks for OHI calculations based on manuscripts published. One thousand five hundred manuscripts were discovered and verified via the Clarivate Analytics Web of Knowledge. We discovered 26 manuscripts each: 12 global, 11 regional, and three local. The trend of manuscripts increased in 2014, 2016, and 2021. Most manuscripts were published in journals focused on multidisciplinary natural resources management and environmental science. The rest of the manuscripts were published in earth and planetary science, ecological science, environment management, biochemistry, and energy journals. The widespread use of OHI requires each country to create comparable measurement techniques by changing the OHI to include factors and indications relevant to each country, including Indonesia.
Is Water Oxidation-Reduction Potential (ORP) value relevant for aquaculture applications in shrimp farming?
Authors: Putri Fernanda Rinia , Budiyanto Imaduddien Raihan , Afauly Rommi Adani Putra
Published: November 2023

Intensive monitoring is essential for shrimp health and productivity, but current water management in shrimp farming is time-consuming due to the need to monitor various parameters. Oxidation-reduction potential (ORP) is a potential water quality summary parameter for shrimp farming, as it's sensitive to water chemistry changes. This study assessed ORP as a summary parameter. Real-time ORP data was collected from a pond in Cipatujah, Tasikmalaya, from September to October 2022. The physical, chemical, and biological water quality data and treatment dosage data were collected to analyze the changes in ORP value over time. The standard deviation for ORP was below 1% for hourly averaging, below 12% for daily averaging, and below 23% for weekly averaging. However, no direct correlation was found between ORP and other water quality parameters. While ORP changed before and after some treatments, it couldn't reliably determine preferred water management conditions due to scattered information. Thus, the current approach of analyzing several parameters remains preferred, as ORP didn't show significant patterns. This suggests that more research is needed to explore alternative approaches for intense yet rapid water quality monitoring in shrimp farming.