bluuebunny/crossref_metadata_2025 huggingface dataset:
A Data-Driven Approach: Investigating Prognostic Factors for Overall Survival in Breast Conserving Surgery (BCS) using Machine Learning
Authors: See Mee-Hoong , Tan Qing-Yi , Lai Lee-Lee , Ng Jing-Hui , Haleem Nadheerah Abd , Yahya Abqariyah , Lim Phaik-Eem , Wu Yang-Sheng , Ling Po-Yu , Pai Tun-Wen
Published: November 2023

Background
Breast-conserving surgery (BCS) is a viable treatment for early-stage breast cancer, but post-operative recurrence is a significant concern linked to mortality. This study leverages Machine Learning and healthcare data to better identify patients at risk of recurrence. The goal is to assess how effectively the model predicts survival factors in breast cancer patients post-BCS.
Methods
This study retrospectively analyzed 1518 breast cancer patients, of whom 430 were excluded due to unknown post-surgery recurrence status from January 1993 to June 2021 using XGBoost model, optimized with grid search and 5-fold cross-validation. Feature importance was determined using the Shapley value technique, and data was collected with SPSS Statistics, Version 28.0, IBM.
Results
The machine learning model showed high effectiveness in predicting patient outcomes, with notable metrics like accuracy (0.947) and precision (0.897). Key findings emphasize the importance of clear surgical margins and reveal that demographic factors like age and race significantly affect prognosis, while luminal subtype and comorbidity are less influential. These insights are crucial for understanding disease recurrence in breast cancer patients after BCS and radiotherapy.
Conclusion
The XGBoost machine learning model demonstrated outstanding predictive performance for outcomes in breast cancer patients receiving BCS and radiotherapy. It confirmed the critical importance of clear surgical margins during initial surgery for prognosis. Demographic factors, especially age and race, were identified as significant predictors of patient outcomes.
A Grid Model of Direct Conversion between Zenith Tropospheric Delay and Precipitable Water Vapor in Tropical Regions
Authors: Jiang Chunhua , Chen Shaoni , Wang Shuaimin , Gao Xiang , Zhu Huizhong , Lu Yangyang , Liu Guangsheng
Published: November 2023

To obtain high-accuracy post and real-time precipitable water vapor (PWV) with simple process when the measured meteorological parameters are unavailable, a grid direct conversion model of zenith tropospheric delay (ZTD) and PWV in tropical regions (named CZP) is proposed with the consideration of the characteristics of spatiotemporal changes based on ERA5 reanalysis data from 2016 to 2019. The results show that the CZP model has good performance at each grid points compared with ERA5 PWV. The comparison results with the GNSS PWV of 61 IGS stations in tropical regions show that the mean bias and root mean square (RMS) of CZP GNSS PWW are no more than 1.1 mm and 1.4 mm, respectively. Furthermore, the CZP GNSS PWV at the co-located stations demonstrates a remarkable correlation with the radiosonde PWV (RS PWV) with the mean correlation coefficient of 0.93 and the bias and RMS of CZP GNSS PWV with respect to RS PWV are 1.61 mm and 3.11 mm, respectively. Additionally, the real-time CZP PWV is compared with the PWV based on GPT3 model with respect to RS PWV after the real-time GNSS ZTD are estimated by Precise Point Positioning (PPP). The results indicate that the real-time CZP PWV has higher accuracy with mean bias and RMS of -0.55 and 3.55 mm, respectively. The above results verify the high accuracy and feasibility of the CZP model for retrieving post and real-time PWV in the absence of measured meteorological data.
Rare environmental and endogenous bacteria isolated from a captive Chinese cobra (Naja atra) with acute enteritis in Hainan, China
Authors: Guo Guiying , Di Zihao , Yang Nuo , Fan Lixia , Li Xuesong , Zeng Jifeng , Zheng Jiping
Published: November 2023

Background: Etiology was investigated of a case of moribund captive juvenileChinese cobra (Naja atra).
Methods: Necropsy, histopathology were described, and bacterial examination was performed.
Results: Acute enteritis was diagnosed for signs of intestinal bleeding and intacttissues. Opportunistic infection occurred including three intestinal inhabitant species (Providencia rettgeri isolated from trachea, Proteus penneri isolated from the lungs, and Proteus vulgaris isolated from the heart) and three environmental species (Bordetella trematum in lungs, Acinetobacter venetianus in liver, and Alcaligenes faecalis in kidneys and spleen).
Conclusions: Our findings implied the exogenous and endogenous bacterial infection would take place under the vulnerable and susceptible condition caused by acute enteritis, and for the first time highlighted abnormal invasions of A. faecalis in the spleen, P. vulgaris in the heart, and A. venetianus in the liver in wild Chinese cobra.
Exploring the Influence of Perceived Extroversion in Embodied Virtual Agents on Trust and Likability
Authors: Lithoxoidou Evdoxia Eirini , Stamos Angelos , Triantafyllidis Andreas , Georgiadis Charalampos , Avonds Joke , Altsitsiadis Efthymios , Giakoumis Dimitris , Votis Konstantinos , Dewitte Siegfried , Tzovaras Dimitrios , Eleftherakis George , Prescott Tony
Published: November 2023

Embodied virtual agents (EVAs) are increasingly used as means of communication with individuals in everyday life. However, first and foremost, these artificial intelligence technologies need to be trusted and liked if users are to widely adopt it. The utilization of implicit nonverbal cues, can play a key role in human-agent interaction by eliciting positive feelings, to stimulate adoption. The aim of this paper is to examine whether nonverbal cues applied to an embodied agent’s appearance, i.e., facial expressions and body posture cues, affect trust and likeability. In accordance with a prior human study categorizing non-verbal cues into extroverted and introverted categories, a selection of such non-verbal cues was made. Afterwards, 382 individuals recruited through Amazon Mechanical Turk agreed to participate in the study. Participants’ personality traits were assessed using the Big Five Inventory – 2S and agent’s perceived extroversion trait was defined with two items from the 10-item measurement of the Big Five. The results showed that an agent’s perceived extroversion class (introvert vs extrovert) based on facial expressions and body posture, was correctly identified by participants (p=.014). Besides, there is evidence for significant results verifying the similarity effect on trust (p <.01) but not on likability. Participants trusted more the agent that was perceived with similar level of extroversion but they liked more the agent perceived as extrovert regardless of their level of extroversion. Thus, manipulating perceived extroversion of EVAs may be an important factor which should be incorporated into human-agent interaction.
Intraoperative spectroscopic evaluation of sentinel lymph nodes in breast cancer surgery
Authors: Barkur Surekha , Boitor Radu A. , Mihai Raluca , Gopal Navarasi S Raja , Leeney Samuel , Koloydenko Alexey , Khout Hazem , Rakha Emad , Notingher Ioan
Published: November 2023

Purpose
Sentinel lymph node (SLN) biopsy is a standard procedure for patients with breast cancer and normal axilla on imaging. Positive SLNs on histological examination can lead to a subsequent surgery for axillary lymph node clearance (ALNC). Here we report a non-destructive technique based on autofluorescence (AF) imaging and Raman spectroscopy for intra-operative assessment of SLNs excised in breast cancer surgery.
Methods
A microscope integrating AF imaging and Raman spectroscopy modules AF was built to allow scanning of lymph node biopsy samples (AF imaging determined optimal sampling locations for Raman spectroscopy measurements). After optimisation of the AF image analysis and training a classification models based on data from 85 samples (scanning 20–30 minutes), the AF-Raman technique was tested on an independent set of 81 lymph nodes. Sensitivity and specificity were calculated using post-operative histology as a standard of reference.
Results
The area under the receiver operating characteristic (ROC) curve for the AF-Raman technique was 0.93. For a regime that maximised specificity (reduce risks of false positives), an accuracy of 97% specificity and 80% sensitivity was achieved. The main confounders for SLN metastasis were areas rich in histiocytes clusters, for which only few Raman spectra had been included in the training dataset.
Conclusions
This preliminary study indicates that with further development and extension of the training dataset (inclusion of Raman spectra of capsule and histiocytes clusters), the AF-Raman is a promising technique for intra-operative assessment of SLNs. Intra-operative detection of positive biopsy could avoid second surgery for axillary clearance.
How psychiatrists and psychiatry trainees perceive their social support, work and loneliness associated with depression?
Authors: Pitanupong Jarurin , Anantapong Kanthee , Aunjitsakul Warut
Published: November 2023

Background
This study aimed to survey the prevalence of depression and its associated factors (perceptions towards social support and work and loneliness) among psychiatrists and psychiatry trainees.
Methods
This cross-sectional study surveyed Thai psychiatrists and psychiatry trainees from January to February 2023 using an online questionnaire. The questionnaires consisted of 1) the demographic and work-related information; 2) perceptions towards social support and work; 3) the Patient Health Questionnaire-9 (PHQ-9) Thai version; and 4) the 6-item Revised UCLA Loneliness Scale Thai version. All data were analyzed using descriptive statistics, and the associated factors concerning depression were analyzed via multiple linear regression analyses.
Results
Of the 225 total participants, 52(23.1%) and 173 (76.9%) were psychiatry trainees and psychiatrists, respectively. Most of them were female (64.9%) with overall median age (interquatile) was 34 (30, 42) years. Regarding the PHQ-9 findings, the prevalence of depression among all participants was 12.4% (psychiatrists 13.9% and psychiatry trainees 7.7%). From regression analyses, depression was associated with loneliness and perceived levels of work satisfaction and work stress in psychiatrists, while in psychiatry trainees, depression was associated with loneliness and perceived level of ability to control work schedule.
Conclusions
13.9% and 7.7% of psychiatrists and psychiatry trainees, respectively, had depression. Loneliness and perception about work satisfaction, work stress, and ability to control the work schedule were key contributing factors to depression. Although the prevalence of depression in this study was not extremely high, action is required to reduce the depression rate among mental health personnel.
IRB / IEC Certification: 65-488-3-1
The L27 Domain of MPP7 enhances TAZ-YY1 Cooperation to Renew Muscle Stem Cells
Authors: Fan Chen-Ming , Shao Anwen , Kissil Joseph
Published: November 2023

Stem cells regenerate differentiated cells to maintain and repair tissues and organs. They also replenish themselves, i.e. self-renewal, for the regenerative process to last a lifetime. How stem cells renew is of critical biological and medical significance. Here we use the skeletal muscle stem cell (MuSC) to study this process. Using a combination of genetic, molecular, and biochemical approaches, we show that MPP7, AMOT, and TAZ/YAP form a complex that activates a common set of target genes. Among these targets, Carm1 can direct MuSC renewal. In the absence of MPP7, TAZ can support regenerative progenitors and activate Carm1 expression, but not to a level needed for self-renewal. Facilitated by the actin polymerization-responsive AMOT, TAZ recruits the L27 domain of MPP7 to up-regulate Carm1 to the level necessary to drive MuSC renewal. The promoter of Carm1, and those of other common downstream genes, also contain binding site(s) for YY1. We further demonstrate that the L27 domain of MPP7 enhances the interaction between TAZ and YY1 to activate Carm1. Our results define a renewal transcriptional program embedded within the progenitor program, by selectively up-regulating key gene(s) within the latter, through the combination of protein interactions and in a manner dependent on the promoter context.
Integrating Climate Change Variables in Relative Humidity Prediction with Multivariate ARIMA and RNN Models
Authors: Sarker Rana , Rasel H. M. , Hossain ABM Shafkat , Mamun Abdullah Al , Saki Saleh Ahmad , Saleh Md. Abu
Published: November 2023

The study of relative humidity has gained significant attention in recent years due to its influence on climate change along with the global warming phenomenon. The precise prediction of these phenomena is crucial in various fields, encompassing meteorology, climate simulation, industrial production, agriculture, public health, and epidemiology. Nevertheless, the task of predicting relative humidity remains a persistent issue owing to its vulnerability to various climate-related influences. The current research employs two techniques, specifically Multivariate ARIMA and RNN models, in order to predict the monthly relative humidity in Chapainawabganj, Bangladesh. This study examines the interconnections of climate change, global warming, and Relative Humidity by incorporating many associated factors such as precipitation, wind speed, palmer drought severity index, and temperature. We employ data from the period spanning 1981 to 2011 for the purpose of training our model, whereas data from the years 2012 to 2021 is used exclusively for testing. In the study area, the proposed model had the lowest root mean squared error (5.10–5.65), the lowest mean absolute error (3.76-4.22), the highest correlation coefficients (0.95-0.96), the highest coefficients of determination (0.90-0.92), and the highest Willmott's index of agreement (0.98) for predicting relative humidity. The study concludes that the Multivariate RNN model (a non-linear model) exhibits superior performance in predicting relative humidity compared to the Multivariate ARIMA model (a statistical model). Our model could help to predict relative humidity across the world incorporating the effects of climate change.
QSPR analysis of drugs for anti-hypertension using degree based topological indices through M-polynomial and NM-polynomial
Authors: A Pradeepa , P Arathi
Published: November 2023

There are several uses for chemical graph theory in experimental science, medicine, drug development, and clinical studies. The statistical characteristics of medications have been developed and determined by topological descriptors. To extract a quantitative structural property/activity relationship (QSPR/QSAR), these indices can be employed alone or in conjunction with other numeric descriptors. Scientists are interested in investigating the chemical network's topology through QSPR investigations, employing specific mathematical constants and parameters derived from the molecular structures of networks. This paper focuses on using the M-polynomials and NM-polynomials of nine anti-hypertensive drugs to compute several degree-based topological indices. It is further shown that these topological descriptors have an excellent correlation with the physicochemical properties of considered anti-hypertensive drugs. Different statistical parameters are analyzed based on the collected results and conclusions are made for each parameter. Researchers exploring drug science in the pharmaceutical sector can utilize the findings to acquire a better understanding of the physical characteristics of newly discovered drugs that are used to treat various diseases.
Mathematics Subject classification (2020): 92E10; 05C09; 05C31; 05C90; 05C92
Towards an intelligent and adapted small scale landslides Monitoring system in East Africa: Shyira Landslide Monitoring Using Sentinel - 1 SAR data On Google Earth Engine Cloud Computing
Authors: Hakizimana Bernard , CHUKWU Kingsley
Published: November 2023

Rainfall-induced landslides pose significant threats in the North-Western provinces of Rwanda, contributing to major disasters. This paper addresses technological challenges in disaster response, specifically focusing on soil displacement quantification. The study concentrates on the local scale around Mukungwa River, employing remote sensing techniques and community science. The methodology involves using INSAR polarization and phase measurements, with a focus on Shyira Landslide Monitoring using Google Earth Engine Cloud Computing.
A citizen science approach was integrated into the study's framework. The methodology for landslide detection included the careful selection of an Area of Interest (AOI) and distinct time periods Before Event (BEvent) and After Event (AEvent) corresponding to the landslide occurrence.
For a comprehensive representation of ground surface properties before and after the landslide event, SAR image stacks were generated. These stacks, calculated as temporal medians of SAR data, were constructed for ascending data, descending data, and a combination of both. Landslide detection involved assessing changes in the backscatter coefficient using the standard SAR intensity log ratio approach.
The classification process categorized changes into three classes: stable, subsidence/decrease, and increase/uplift. To gain deeper insights, a CSV file was generated for statistical analysis, providing a quantitative examination of the landslide event dynamics. The study conducted comprehensive statistical analysis and derived meaningful recommendations.
This research contributes to the understanding of landslide monitoring through a robust methodology that combines remote sensing technologies, community engagement, and statistical analysis. In a sample of data containing 885,632 points generated from imagery within the study area, using Python script code. This dataset was utilized to create a pair plot, effectively visualizing the before-event and after-event data and these have presented a strong correlation.
In a sample of the 5,000 households in the study area, 96 were completely destroyed and 231 heavily damaged .The findings and recommendations have implications for disaster response strategies and underscore the importance of technological advancements in addressing the challenges posed by landslides.
THE MODEL OF INFORMATION MESSAGE OF MONITORING RESULTS IN CASE EMERGENCIES OR EMERGENCY THREATS IN THE BORDER ZONES OF RADIOACTIVE CONTAMINATION IN RUSSIA AND BELARUS
Authors:   Nuclear Safety Institute of the Russian Academy of Sciences, Apanasyuk Oleg N.
Published: November 2023

The article describes model of the structure of the interstate information message is presented task is prompt and detailed transfer of information on emergency situations and their consequences through the automated systems of data exchange between the regional departments of the EMERCOM of Russia (Bryansk region) and the EMERCOM of the Republic of Belarus of border areas (Gomel and Mogilev regions).The digital representation of the data in the message is based on the use of joint electronic directories: on the settlements in Gomel and Mogilev regions of the Republic of Belarus, Bryansk region of the Russian Federation; on interstate standards on radiation remedial measures and electronic exchange of information; on emergencies and their scale; on weather conditions. The structure of an electronic message has been developed on the basis of a number of joint electronic directories designed to support information exchange procedures, provided that the volume of transmitted data is minimized and the level of detail about emergencies and/or their threats in the zones of radioactive contamination of the border areas of Russia and Belarus is expanded.
PREVENTION OF OCCUPATIONAL INJURIES WHEN CONSTRUCTING POWER LINES
Authors:   Irkutsk National Research Technical University, Raspopina Dar’ya S. , Volchatova Irina V. ,   Irkutsk National Research Technical University
Published: November 2023

Recently, Russia has seen an increase in the number of people injured as a result of fatal occupational accidents. One of the traumatic industries is the electric power one. The article analyzes causes of electric shocks. Among 13 causes, the first place is occupied by direct contact with overhead power lines (46%). On the example of developed countries, examples of technical measures that can prevent industrial injuries when constructing power lines are provided. The main technical tool used in their construction is supports based on sectioned reinforced concrete racks. Its advantage is simplification. Reducing the installation time of reinforced concrete supports can decrease severity of the labor process, and concrete as a natural grounding conductor increases electrical safety.
Foliar application of kinetin modulates the cannabinoid content and transcriptome of Cannabis sativa L.
Authors: Deng Canhui , Wu Shan , Jin Xiangfan , Yang Zemao , Tang Qing , Dai Zhigang , Cheng Chaohua , Xu Ying , Zhang Xiaoyu , Su Jianguang
Published: November 2023

Cannabis sativa is highly cultivated owing to its secondary metabolites, especially cannabinoids, which possess several medicinal effects. This study aims to examine the effect of foliar application of kinetin (KT) on the growth, cannabinoid content, and transcriptome of C. sativa at the flowering stage. A pot experiment was conducted in a greenhouse under a 16h/8h light/dark cycle for growing, and the photoperiod was adjusted to 10h/14h to induce flowering. The plant was sprayed with 0, 20, 40, and 100 mg/L KT every 2 days for a total of six times. Phenotypic parameters (fresh weight, cannabinoid content, and enzyme activity) and metabolome were analyzed. Foliar application of 20 and 40 mg/L of KT increased the growth and cannabinoid content of C. sativa, particularly that of cannabidiol. Similarly, treatment with 20 mg/L of KT increased the Δ9-tetrahydrocannabinolcontent to 0.24%, which is below the legal value of 0.30% in North American countries. Plants treated with 20 and 40 mg/L of KT showed decreased activities of 3-hydroxy-3-methylglutaryl coenzyme A reductase and 1-deoxy-D-xylulose 5-phosphate synthase. KEGG pathway analysis showed that differentially expressed genes (DEGs) in the KT-treated cannabis were mainly enriched in 12 pathways, including sesquiterpenoid and triterpenoid biosynthesis, linoleic acid metabolism, flavonoid and phenylpropanoid biosynthesis, and other secondary metabolic pathways; 14DEGs (including eight upregulated and six downregulated genes) were enriched in sesquiterpene and triterpene biosynthesis pathways. Overall, these findings showed that KT plays a significant role in regulating terpenoid biosynthesis and the cannabinoid content of C. sativa
Edaphoclimatic and genetic influence on soil water availability factor for different sugarcane varieties
Authors: Anjos João Carlos Rocha Dos , Júnior José Alves , Casaroli Derblai , Paixão Jéssica Sousa , Jardim Carlos Cesar Silva , Costa Fernando Rezende da , Evangelista Adão Wagner Pego , Júnior Aderson Soares de Andrade , Silva Gustavo Cassiano da , Battisiti Rafael
Published: November 2023

Sugarcane is grown in all Brazilian states; however, water stress is the main limiting factor of crop productivity in most farming environments (FEN). Thus, the objective was to verify the water availability factor in the soil (factor f) between FEN and sugarcane varieties. The assay was conducted in the Central and Southern Regions of Goiano, in Red Latosol with distinct physical-water attributes among the FEN. Three varieties of sugarcane - Vs (CTC4, RB966928 and RB867515), five factor f (0.41; 0.46; 0.66; 0.72; and 0.84), and two cultivation environments (Goianésia and Quirinópolis), in a sugarcane plant cycle (2019/2020) were evaluated. The randomized block design was used in a factorial scheme (3x5x2), with four replications. The physiological variables (liquid photosynthesis - Lp, stomatic conductance - Sc, leaf transpiration - Lt and temperature gradient leaf atmosphere - TGLA), ton of stalk per hectare - TSH, total recoverable sugars - TRS, ton of POL per hectare - TPH, sugar and alcohol. They were submitted to the F test, mean comparison and quadratic regression. The Sc, Lt and Lp differed statistically between themselves and between FEN, when submitted to the same factor f and Vs, reflecting in penalty in TSH and POL, TRS , sugar and alcohol. Indicating that factor f varies, both between FEN and between Vs. CTC4 has higher productive potential than other Vs; however, more sensitive to soil water depletion (lower factor f), reflecting lower Lp and TSH in both FEN. The factors of soil water availability to avoid water stress were 0.5, 0.49 and 0.47 for RB867515, RB966928 and CTC4, respectively, in Quirinópolis; and 0.47, 0.47 and 0.44 for RB867515, RB966928 and CTC4, respectively, in Goianésia
The effects of the different sowing methods and planting density on the yield components of soybean (Glycine max) under intercropping condition with rhodes grass (Chloris gayana Kunth.)
Authors: Prasojo Yogi Sidik , Niimi Mitsuhiro , Hashiguchi Masatsugu , Muguerza Melody , Ishigaki Genki
Published: November 2023

In Japan, grass-legume intercropping systems are being developed to increase quality and yield of grain and forage. Hence, this study evaluated the effects of sowing methods and planting density on yield traits of forage soybean under intercropping condition with rhodes grass. The field experiment was laid on in a completely randomized block design with four treatments and four replications. Rhodes grass seeds were sown at 2.8 kg/10a in a field containing mono- and intercropping-plots. For soybeans, two levels of sowing densities (about 15 or 30 seeds/m2: named “L” and “H”) and two sowing methods (row or spray: named “R” and “S”) were applied for a total of four different intercropping combinations. Rhodes grass DMY obtained the highest in low level of sowing density with rowing methods (LR) (338 kg/10a) while soybean DMY obtained the highest in high level of sowing density with rowing methods (HR) (251 kg/10a) and in high level of sowing density with spray methods (HS) (177 kg/10a). Intercropping at low density increased CP (12%) and CPY (40.4 kg DM/10a) in Rhodes grass, and CP (18.9%) in soybeans, whereas high sowing density increased soybean CPY in HR (41.5 kg DM/10a) and contributed to higher soybean CPY in DM percentage at 66% (HS) and 56% (HR). Overall, high density sowing increased the 1st total DMY while row sowing increased the 1st total CPY in both crops at the first cutting, while monocropping increased Rhodes grass yield and plant length at the second-cutting. Also, sowing soybean by a broadcast spreader could obtain sufficient crude protein yield as a forage soybean in southern Kyushu, Japan. Further studies are needed for soybean overseeding method and use of early-maturity soybean lines
Fuentes literarias y pictóricas para las imágenes de san Francisco de Asís en la Baja Edad Media
Authors: RODRIGUEZ VELASCO MARIA
Published: November 2023

Las imágenes de san Francisco de Asís se multiplican en Europa con la función de servir de modelo a los frailes menores y despertar la veneración de los fieles mediante el conocimiento de los episodios más significativos de su hagiografía. Para comprender el significado último de estas representaciones es necesario recordar dónde fueron realizadas, aunando aspectos formales y fuentes literarias que sir­vieron de inspiración a los pintores de la Baja Edad Media. En las siguientes líneas veremos el importante papel de los franciscanos como comitentes, la difusión de las biografías de Tomás de Celano y san Buenaventura y su recepción en las imágenes, especialmente, a partir de los frescos de Giotto di Bondone en Asís.
Estos constituyen un punto de inflexión en la evolución de los repertorios franciscanos, por su renovación e incidencia en la consoli­dación de símbolos parlantes y fórmulas de representación de carácter narrativo en la iconografía franciscana. No es objeto de este trabajo la catalogación de imágenes, sino reseñar las principales variables de la imagen de san Francisco desde el siglo xiii al xv a partir de piezas muy elocuentes respecto a su origen y evolución posterior.
Michel Henry, lector de Meister Eckhart: Vínculo entre la mística especulativa y la fenomenología de la Vida
Authors: Di Giacomo Z Mario
Published: November 2023

En este artículo se revisa el lugar que ocupa Eckhart en L’essence de la manifestation, a fin de establecer correspondencias y afini­dades entre el místico renano y la peculiar concepción que de la fenomenología sostiene Michel Henry. Se trata de analizar la es­trecha cercanía entre el alma humana y Dios postulada por Meister Eckhart y su vinculación con la conocida noción de Vida presente en el autor francés. Henry es proclive a fundar una filosofía primera asociada a la pura autoafección, describiendo la Vida sea como pura inmanencia, sea como una ipseidad algo problemática. En general, el trabajo teórico de los representantes del “giro teológico de la fenomenología francesa” (Janicaud) cuestiona al sujeto clásico de la Modernidad, sin por eso traer a colación la causa de un Dios Revelado ni el que resulta de una teología natural. Este trabajo, en suma, no es el esfuerzo de pensar a un Dios confesional ni tiene un propósito evangélico. Lejos de ello, se trata de precisar el nexo entre Henry y Eckhart, puesto en escena por aquél, y si tal nexo es coherente con lo que Henry piensa acerca de un modo de manifestación que ya no implica distancia fenomenológica alguna: la manifestación del pathos de la Vida.
Experience in the lower extremities trophic ulcers treatment in patient with combined pathologies: varicose veins and rheumatoid arthritis
Authors: Gavrilov K. А. , Markina V. А. , Sevostyanova K. S. , Shevela A. I.
Published: November 2023

Varicose veins of the lower extremities is one of the most common diseases on Earth and its combination with other diseases is inevitable. The combination of diseases aggravates the course of each other. Rheumatoid arthritis worsens the course of varicose veins with trophic disorders – both independently – an increase in pro-inflammatory factors, a change in microcirculation, deformation of the limb axis with a violation of musculoskeletal function, and treatment of rheumatoid arthritis reduces the immune response of the body reducing the reparative capabilities of the body. Clinical case: a patient with a long course of rheumatoid arthritis and varicose veins. For a long time he used cytostatic drugs with a subsequent transition to hormonal drugs. For about 5 years, he noted the appearance of ulcers on both shins, which took a circular shape, which significantly reduced the quality of life and did not respond to conservative treatment. He repeatedly underwent inpatient treatment with intravenous administration of general restorative and vascular drugs. He was also constantly observed in the polyclinic at the place of residence with the implementation of local treatment of ulcerative surfaces. The patient was successively treated for varicose veins by endovenous laser coagulation of the trunks of large subcutaneous veins. The second stage was performed debridement of the wound surface and skin grafting with a free perforated flap. Between the stages, the appointment of drug therapy according to clinical recommendations. Rheumatoid arthritis and varicose veins aggravate each other, especially trophic manifestations. Treatment of such patients should be carried out by a team ofspecialists of various profiles together. Step-by-step treatment ofsuch patients with careful preparation for each of them shows excellent results. A special place is occupied by the patients’ commitment to treatment.
Application of navigation system in colonoscopy
Authors: Vasilchenko A. V. , Skridlevskiy S. N. , Likutov A. A. , Merkulova E. S.
Published: November 2023

Introduction. There are opinions that the use of modern high-tech additional techniques, including a navigation system for positioning a colonoscope (MEI), can both increase the diagnostic efficiency of colonoscopy and its comfort for the patient, and do not affect the quality of colonoscopy. Aim. To determine the capabilities of MEI during colonoscopy without sedation. Materials and methods. The single-center, prospective, randomized study included 120 patients (from 20 to 82 years, mean age 51.8 years; 53% men / 47% women) who underwent routine diagnostic outpatient colonoscopy using a rotational technique by experienced endoscopists using MEI navigation system. The study took place in two stages: Stage 1 – randomization and assessment of group comparability (group 1 – MEI, n = 57 and group 2 – without MEI, n = 63); Stage 2 – determination of the number of patients with colon preparation for colonoscopy according to the Boston scale > 6 points (n = 112: 1st study-MEI group, n = 52 and 2nd control group, n = 60); comparative analysis between groups of the frequency of cecal intubation, time of cecal intubation, pain assessment on the VAS scale in cm. Statistical analysis was carried out using Fisher’s exact test, two-sided Mann-Whitney rank sum U test at a significance level of 0.05. Results and discussion. The groups were comparable in age, gender, preliminary indications for the study. The cecum was intubated significantly more often in group 1 (100% vs 90%, p < 0.05). There was no significant difference in the time required for cecal intubation (p = 0.258) and the difference in the mean time required for cecal intubation was 22 seconds. The VAS pain assessment also did not reveal significant differences (p = 1.023). We determined that the increase in the frequency of cecal intubation using MEI by experienced endoscopists increases by 10% and reaches 100%, while the opinion about reducing the time of cecal intubation and improving patient comfort were not confirmed. Conclusion. MEI during rotational colonoscopy performed by experienced endoscopists increases the likelihood of cecal intubation during routine colonoscopy by 10%. MEI does not increase the time required for cecal intubation and is not associated with the frequency or intensity of pain or discomfort on the VAS scale in colonoscopy without sedation.
Phlebopathies: from pathogenesis to treatment
Authors: Bogachev V. Yu. , Boldin B. V. , Turkin P. Yu. , Dzhenina O. V. , Alukhanyan O. A. , Bogacheva N. V.
Published: November 2023

Introduction. The prevalence of phlebopathies varies from 15 to 31%. The QoL of patients with phlebopathies is impaired. Phlebotropic therapy is the main method for treating phlebopathies. Aim. Evaluation of the efficacy and safety of micronized purified flavonoid fraction (MPFF) (Troxaktiv). Materials and methods. A total of 129 females aged 18 to 45 years (average age of 35,2 ± 4,1 years) were included in the open observational study. To exclude pathology of the principal veins of the lower extremities, all patients underwent ultrasound examination, as well as photoplethysmography with automatic measurements of the venous refilling time and the power of the calf muscle-venous pump. All patients were divided into three groups: Group 1 received MPFF at a daily dose of 1000 mg only, Group 2 – class I compression hosiery in addition to MPFF, Group 3 – a course of psychotherapy and guidelines on lifestyle changes, augmentation of physical activity, etc.Results. Due to ongoing treatment measures, positive changes with decreased number of complaints and their intensity were observed. Positive changes occurred mainly in the groups of patients receiving phlebotropic therapy and combined phlebotropic/compression therapy: the number of patients with vein-specific symptoms decreased by more than half, while 31 patients reported the persistence in complaints at baseline level or their slight decrease while taking psychotherapy course and lifestyle changes. The specific therapy groups reported a significant dynamic reduction in the feeling of heaviness and pain as well as night cramps in the calves. Discussion. In the presented study, the patients were prescribed MPFF/Troxaktiv™ at a daily dose of 1000 mg, both as monotherapy and in combination with compression. A significant decrease in the frequency and severity of vein-specific symptoms and a significant increase in the patients’ quality of life was recorded in both of these groups. Photoplethysmography results showed an improvement in elastic rebound properties of the venous wall. All patients were satisfied with the treatment. Conclusion. MPFF/Troxaktiv™ has demonstrated high efficacy and safety in the treatment of patients with phlebopathies of various origins.
The register as a tool for researching trends in phlebological care for the population of a large industrial center of Russia
Authors: Burleva E. P. , Peshkov A. V. , Tyurin S. A. , Belentsov S. M. , Vinogradov O. A. , Leshchinskaya A. Yu. , Lobut O. A. , Zasorin A. A.
Published: November 2023

Introduction. The Russian Phlebological Register began work in 2016 under the patronage of the Association of Phlebologists of Russia. The creation of a phlebological register in a separate municipal center of the country complements and enriches national plans. Aim. Тo investigate the trends in the organization of medical care to the population with chronic venous diseases (CVD) of a large industrial center using the phlebological register over the past 20 years. Materials and methods. The data of municipal and private medical institutions of Ekaterinburg from 2003 to 2022 are analyzed. Data on municipal hospitals (MHs) are provided by the TFOMS of the Sverdlovsk region. Data on private medical centers (PMCs) are obtained by exporting them from the electronic databases of each center. The statistics of phlebectomies (PhE), outpatient minimally invasive interventions and procedures are summarized. Results. Over the entire period of time, the number of classical phlebectomies in MHs decreased by 4 times – from 2300 (2003) to 587 (2022). At the same time, the development of minimally invasive procedures on the main veins in the PMCs increased from 313 (2003) to 4364 (2022). This made it possible to double the coverage of patients suffering from CVD with specialized medical care. In the structure of patients operated in MHs, the proportion of persons with severe chronic venous insufficiency (CVD C4–6) significantly decreased. The number of patients with superficial thrombophlebitis had a steady downward trend: the first 5 years (2003–2007) – about 200 PhE/year, then 5 years (2008–2012) – about 120 PhE/year, and from 2013 to 2022 < 100 PhE/year. Discussion. Private medical centers have consistently introduced the latest technologies, but endovasal laser coagulation remains the leader. Conclusion. The analysis of the register revealed a number of systemic changes in the organization of phlebological care.
Complications of spinal and general anesthesia for total knee arthroplasty
Authors: Abdulahad S. A. , Mohammad H. M. , Abd-Al-Qader B. K.
Published: November 2023

Introduction. General anesthesia (GA) and spinal anesthesia (SA) are the main techniques applied during total knee arthroplasty (TKA). SA belongs to neuraxial anesthesia (NA) category. Numerous studies have explored benefits of NA in diminishing the complications, among which are pulmonary embolism (PE), urinary tract infection (UTI), and deep vein thrombosis (DVT). Aim. To compare rate of complications of SA and GA in TKA. Materials and methods. This is a retrospective cohort studie conducted on 190 patients who attended Alwasity teaching hospital in Baghdad and underwent TKA. The age ranged from 41 to 75 years and 69% of patients were females. The patients were enrolled into SA group (80 patients) and GA group (110 patients). We reviewed patients’ records and interviewed patients and medically examined them to obtain data on age, sex, body mass index (BMI), comorbidities including diabetes mellitus(DM), hypertension (HT) and other comorbidities. Results: Higher age and BMI were found in SA group. Complications’ incidence in SA group vs. GA group was PE 0.03 vs. 0.09, DVT 0.04 vs. 0.10, Pneumonia 0.04 vs. 0.08, UTI 0.06 vs. 0.23, and ARF 0.03 vs. 0.33, they didn’t differ significantly. Conclusion: SA is a good option for anesthesia in TKA because it wasn’t associated with higher complications rate compared to GA.
Neodymium long-pulse laser as a monotherapy for unaesthetic vessels of various locations: a series of clinical observations
Authors: Parikov M. A. , Patsyuk A. V. , Kulagina S. S. , Ozherelev E. V. , Agadzhanyan M. S. , Plotnikov M. V. , Maksimov A. V. , Orudzhev Sh. E. , Zhdanov K. O. , Sinitsyn A. A. , Perkov S. O.
Published: November 2023

The article presents a series of clinical cases describing the successful use of the long-pulse neodymium laser in removing unaesthetic reticular veins and telangiectasia of various locations. The first two cases demonstrated reticular varicose veins of the lower limbs in female patients with a fear of injections, which were treated without compression garments and ecchymoses with excellent effect. The outcome of treatment was comparable with that of classical sclerotherapy. The third case showed a successful laser removal of large telangiectasias on the hands, which developed following the long-term use of injection narcotic drugs as part of trophovegetoneurosis. Such pathology is rare for medical practice and approaches to its treatment have not been developed. The fourth case showed large telangiectasias of the buccal and zygomatic regions A good effect after the use of a large diameter spot in that area was demonstrated. The fifth case demonstrated the treatment of the veins in the buccal region, including the vein curving over the mandibular angle. The outcome of the treatment allowed to evaluate not only the aesthetic effect of the procedure, but also the severity of side effects in that area. In the sixth case, the periorbital vein, which divides into two branches, was investigated. The treatment was successful despite the different structure of the vein wall and depth of occurrence. The seventh case demonstrated the removal of large temporal veins. The outcome of treatment was presented on the following day, reflecting the degree of visual discomfort in the early post-procedure period. The final outcome a month after treatment was also demonstrated. In conclusion, the eighth case demonstrated the effectiveness of the treatment of scattered small red telangiectasias on the face using a long-pulse neodymium laser.
Some new aspects of the pathogenesis of venous trophic ulcers
Authors: Boldin B. V. , Bogachev V. Yu. , Turkin P. Yu. , Somov N. O. , Oettinger A. P. , Varich G. A.
Published: November 2023

Venous trophic ulcers are one of the most common in the population, and costly in terms of treatment costs for complications of chronic venous insufficiency. The prevalence of venous trophic ulcers ranges from 0.18 to 1%. Over the age of 65 it increases to 4%. The cause of the formation of venous trophic ulcers is chronic diseases of the veins of the lower extremities. Chronic disease of the veins is a term that includes a wide range of morphological and functional disorders affecting the venous system. At the same time, even after conservative treatment, the level of recurrence of venous trophic ulcers remains extremely high, which leads to an increase in the duration of treatment for patients in the hospital, in some cases causing permanent disability in patients of working age. The literature has accumulated a huge volume of both fundamental and clinical research on the etiology, pathogenesis, diagnosis and treatment of venous ulcers. However, despite the numerous studies, the number of patients with this disease continues to steadily increase, and a number of important aspects of the pathogenesis have not yet been studied. In addition, these works do not allow us to formulate a unified concept of the pathogenesis of venous ulcers, which in turn affects the effectiveness of treatment of venous trophic ulcers. Our study highlights modern aspects of the pathogenesis of venous trophic ulcers, which may be of key importance in the treatment of this pathology. Promising directions of scientific research in this area are determined. This requires a more in-depth study of aspects of intercellular interactions, and also opens up the prospect of searching for new methods of influencing the pathogenesis of venous trophic ulcers, taking into account the presence of microflora resistant to standard antibacterial agents.
Features of treatment of haemorrhoids in overweight patients
Authors: Turkin P. Yu. , Dizengof I. M. , Varich G. A.
Published: November 2023

Hemorrhoidal disease is one of the most common proctological diseases in the population, covering, according to a number of authors, from 4 to 86% of the population over the age of 40 years. In addition, the problem of metabolic syndrome and accompanying obesity have become a real disease of the century in developed countries. This condition predisposes to a large number of diseases, including hemorrhoidal disease. From these positions, it is advisable to highlight the possibilities of treating not only hemorrhoids themselves, but also combating metabolic syndrome in this category of patients. The article describes modern data on the therapeutic effect of bioflavonoids, in particular hesperidin, and the mechanisms of their therapeutic action in acute and chronic hemorrhoids. The possibilities of using topical therapy for hemorrhoids are also highlighted, attention is paid to suppositories based on sodium alginate, thanks to which the drug has a hemostatic, anti-inflammatory and reparative effect, alleviating local symptoms of hemorrhoids and anal fissure. Data are provided on the therapeutic effect of the combination of hesperidin + diosmin in relation to the symptoms of hemorrhoids in patients with excess body weight and to metabolic syndrome are presented, as well as the experience of clinical observation in the hospital of the Faculty of Surgery No. 2 L/F of the N.I. Russian National Research Medical University is presented. Pirogov in the treatment of 1 300 comorbid patients with acute hemorrhoids and exacerbation of chronic hemorrhoids, followed by surgical treatment. The potential benefits of drugs with a standardized content of hesperidin (Venarus®) in relation to the treatment of hemorrhoids in patients with excess body weight and metabolic syndrome, comparison with other drugs from the group of bioflavonoids, are described.