bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying of patients with advanced ovarian cancer experiencing the highest benefit from bevacizumab in the first-line setting on the basis of Kelim score
Authors: Kokanov Dunja , Maksimovic Tamara , Stevanovic Nemanja , Maricic Slobodan , Lukac-Paulic Sonja , Savic Kristina
Published: February 2025

Introduction. Ovarian cancer represents the deadliest gynecological
malignancy. The aim of this study is to validate the predictive value of
Cancer antigen-125 Elimination rate constant K score regarding
progression-free survival among patients with Stage IIIc-IV high-grade
serous ovarian cancer according to the International Federation of
Gynecology and Obstetrics, treated with bevacizumab. Additionally, the study
aims to determine the significance of a score in the assessment of
progression-free survival in relation to operation status and disease stage.
Material and Methods. The retrospective study was conducted at the Oncology
Institute of Vojvodina and included 56 patients treated for high-grade
serous ovarian cancer. The treatment protocol consisted of chemotherapy with
paclitaxel and carboplatin, followed by bevacizumab maintenance therapy. The
Cancer Antigen- 125 Elimination Rate Constant K score was calculated using
three Cancer Antigen 125 tumor marker values. Based on this calculation, the
score was dichotomized into favorabe (?1) and unfavorable (<1) groups.
Results. The analysis of the score?s impact on progression-free survival
revealed that patients with a score ?1 had longer mean survival time
compared to a score <1 (19.4 vs 17.0 months). This difference was not
statistically significant (p=0.549). The operation status in relation to a
score was the only statistically significant factor with progression-free
survival benefit (p=0.002). Conclusion. In our study, Cancer antigen- 125
Elimination rate constant K score did not emerge as a statistically
significant prognostic factor for identifying patients most likely to
benefit from bevacizumab. The operative status showed significant predictive
value.
Efficacy and Safety of Finerenone in Type 2 Diabetes: A Pooled Analysis of Trials ofHeart Failure and Chronic Kidney Disease
Authors: Ostrominski John W. , L. Claggett Brian , Michael Miao Zi , Filippatos Gerasimos , S. Desai Akshay , S. Jhund Pardeep , Henderson Alasdair , Brinker Meike , Schloemer Patrick , Viswanathan Prabhakar , Lage Andrea , Rohwedder Katja , S.P. Lam Carolyn , Senni Michele , J. Shah Sanjiv , A. Voors Adriaan , Zannad Faiez , Rossing Peter , M. Ruilope Luis , D. Anker Stefan , Pitt,Bertram Pitt Bertram , Agarwal Rajiv , J.V. McMurray John , D. Solomon Scott , Vaduganathan Muthiah
Published: February 2025

Objective: To evaluate the efficacy and safety of finerenone, a non-steroidal mineralocorticoid receptor antagonist, in individuals with type 2 diabetes (T2D) and either chronic kidney disease (CKD) or heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF).

Research Design and Methods: In this prespecified participant-level pooled analysis of all phase III clinical trials evaluating finerenone versus placebo conducted to date (FINE-HEART), the safety and efficacy of finerenone was evaluated among participants with a history of T2D. Treatment effects on the primary outcome of cardiovascular death and other secondary outcomes were evaluated according to baseline glycated hemoglobin (HbA1c) and glucose-lowering therapy (GLT) regimen using stratified Cox proportional hazards models.

Results: Of 18,991 FINE-HEART participants, 15,365 (80.9%) had T2D and available HbA1c at baseline (mean age, 66±10 years; 32% women; mean HbA1c, 7.6±1.4%). The most common GLT regimens were insulin alone (n=2,652), insulin and metformin (n=2,005), metformin alone (n=1,616), metformin and sulfonylurea (n=1,039), and “other” (n=8,117; including SGLT2i and GLP-1RA). Over a median follow-up of 2.9 years, treatment effects of finerenone vs. placebo on cardiovascular death were consistent across baseline HbA1c (Pinteraction=0.75) and GLT regimen (Pinteraction=0.46). Finerenone consistently reduced the kidney composite outcome, HF hospitalization, major adverse cardiovascular events, and all-cause mortality, irrespective of baseline HbA1c and GLT regimen. Treatment effects of finerenone were also consistent across number of background GLTs and irrespective of concomitant treatment with a SGLT2i or GLP-1RA.

Conclusions: Finerenone consistently reduced morbidity and mortality in individuals with T2D across a broad range of glycemia and glucose-lowering regimens.
Developing Construction Project Material Procurement Strategy using Integrated FMEA-DEA Approach in Kraljic’s Portfolio Matrix
Authors: Kamil Muhammad Insan , Mulyono Nur Budi
Published: February 2025

This research aims to develop procurement strategies for the Central Services Division at PT Freeport Indonesia, focusing on construction material procurement. The study integrates Failure Modes and Effects Analysis (FMEA), Data Envelopment Analysis (DEA), and the Kraljic’s Portfolio Matrix to address inefficiencies and improve material management practices. These methodologies help identify critical risk factors, assess supplier performance, and categorize materials based on their impact and supply risk. The study identifies that the procurement items are distributed across the Kraljic quadrants as follows: six items in the Leverage quadrant, ten items in the Strategic quadrant, nine items in the Bottleneck quadrant, and nine items in the Non-Critical quadrant. The findings provide a robust framework for enhancing procurement strategies, leading to cost savings, reduced material wastage, and improved operational efficiency.
Analysis of factors influencing students' participation in national and international competitions
Authors: Setia Putri Bunga , Kurniawan Andre , Indrawan Eko , Wulansari Rizky Ema , Kassymova Gulzhaina Kuralbayevna
Published: February 2025

Higher education plays an important role in preparing students to become competent and competitive individuals. Furthermore, participating in academic competitions is a strategic means to foster innovative, collaborative, and competitive skills. This study employed Structural Equation Modeling (SEM) using Smart PLS (Partial Least Squares) software, a statistical technique suitable for analyzing complex relationships between variables. The analysis process involved two stages: measurement model and structural model. The analysis showed that the T-statistic for peer influence was 2.549, exceeding the threshold of 1.96, with a p-value of 0.011, below the 0.05 threshold for statistical significance. Similarly, the T-statistic for family influence was 3.803, also exceeding 1.96, with a p-value of 0.000, indicating a highly significant relationship. These findings highlight the important role of external factors, especially peer and family influence, in motivating students to participate in national and international competitions. Therefore, educational institutions need to implement targeted strategies to increase students’ motivation and encourage active involvement in these competitions.
Castaways and Conquerors: Exposing American Imperialism in Jules Verne’s The Mysterious Island
Authors: Najjarzadeha Mohammad Sadegh
Published: February 2025

At first glance, Jules Verne’s The Mysterious Island seems like a simple adventure story, but a deeper examination reveals how it embodies the ideas prevalent in nineteenth-century America. Focusing on postcolonial and Marxist angles, this article reveals how the castaways’ supposedly perfect society on a deserted isle reproduces processes of colonial expropriation and capitalist appropriation. The absence of Indigenous peoples, the transformation of the island’s landscape, and the collective approach to labor highlight the novel’s engagement with imperial and economic concerns. Additionally, Captain Nemo’s intricate role—opposing colonial rule while also validating and testing the castaways—underscores the narrative’s internal tensions. Ultimately, the essay contends that The Mysterious Island offers a commentary on American identity, emphasizing how it intertwines with expansionist aims and capitalist ideologies, and prompting readers to reconsider what “progress” meant to nineteenth-century audiences.
Strategic Entrepreneurship Mediating the Impact of, Financial Literacy and Use of Social Media on MSMEs’ Entrepreneurial Orientation in Indonesia
Authors: Boseke Reny Estafince , Meiryani Meiryania
Published: February 2025

Purpose: This research aims to determine the influence of financial literacy and social media on entrepreneurial orientation among MSME actors in Indonesia, with strategic entrepreneurship as a mediator.
Method: The research employs a quantitative approach, utilizing data collection through questionnaires. Purposive Sampling was used to select the sample, and the analysis was conducted using Descriptive Analysis and Structural Equation Modelling (SEM) methods).
Result: The development of strategic entrepreneurship skills as a critical mechanism in harnessing the potential benefits of financial literacy and social media use for enhancing entrepreneurial orientation. This mediation suggests that financial knowledge and strategic use of digital platforms are not merely additive but synergistically enhance entrepreneurial capacities through effective strategic actions. This finding underscores the importance of integrating strategic entrepreneurship training and support into financial education and social media usage strategies for MSME actors, to foster a more dynamic and innovative entrepreneurial ecosystem in Indonesia.
Understanding Skintific Product Customer Loyalty Based on Sensory Experience, Value Perception and Satisfaction
Authors: Murna Wardayanti  , Wira Bharata
Published: February 2025

Purpose: This research seeks to explore the influence of sensory experiences and perceived value on consumer satisfaction and loyalty regarding Skintific products among Samarinda's residents.
Method: This study employs a quantitative approach with associative methods. The population consists of Samarinda residents who use Skintific products, with a total of 130 respondents. The sampling technique used is non-probability sampling, specifically the accidental sampling method.
Result: The findings indicate that sensory experience has a significant impact on both customer satisfaction and loyalty. However, perceived value significantly affects customer satisfaction but does not have a notable influence on customer loyalty. However, through an indirect connection, perceived value can impact loyalty via satisfaction. Consequently, the results suggest that customer satisfaction serves a crucial function as a mediator in linking perceived value with customer loyalty. Therefore, initiatives to boost perceived value should align with efforts to enhance customer satisfaction in order to build enduring loyalty.
Tinjauan Perbandingan Hukum Tindak Pidana Perkosaan Dalam Perkawinan (Marital Rape) di Indonesia dan Singapura
Authors: Angkawidjaja Elizabeth Vania
Published: February 2025

Beberapa hal yang melatarbelakangi penelitian yakni perbedaan sistem hukum yang dianut dan kurangnya pengaturan hukum marital rape. Metode penelitian yang digunakan adalah pendekatan yuridis normatif dengan pendekatan perbandingan, dan spesifikasi penelitian deskriptif analitis. Hasil penelitian menunjukkan bahwa pengaturan hukum marital rape di kedua negara, masing-masing memiliki sisi positif dan negatif. Kontribusi pengaturan hukum marital rape Singapura memberikan contoh upaya preventif yang setara baiknya dengan Indonesia dan upaya represif berupa penangkapan pelaku perkosaan tanpa surat perintah, perintah perlindungan tambahan bagi korban KDRT, dan diaturnya sexual consent dalam regulasi hukum mereka.
Michel Foucault y la revolución islámica de Irán: el nacimiento de un gobierno islámico desde la espiritualidad política
Authors: Haoulo Mubayed Mohammad , Rodriguez Barroso Rosmel
Published: February 2025

En su viaje a Irán en 1978, el pensador y filósofo Michel Foucault trata de comprender los elementos fundamentales de la revolución islámica en Irán, exponiendo su punto de vista sobre el poder y su relación con los movimientos sociales en el mundo oriental. Foucault, abandonó los modelos teóricos occidentales, para explicar los litigios que fueron causantes de la revolución. De esta forma, el pueblo de Irán ya había decidido tomar el camino del cambio, una transición que se ajustó a la religión islámica, instituyendo una cultura apegada en la rama chiita, que a su vez unificó la energía de las masas que reflejó la voluntad general – la Espiritualidad Política – en contra del gobierno del Shāh.
Temporal Analysis of Rainfall Characteristics in Response to Climate Change in the Special Region of Yogyakarta Province
Authors: Mashuri Imawan , Fadhli Aslama Afghani  , Ofana Tri Wibowo
Published: February 2025

Climate change has resulted in uneven rainfall variations. The temporal analysis of rainfall in the Special Region of Yogyakarta Province was conducted through the calculation of monthly averages, seasonal averages, and annual trends using the Climate Data Operator (CDO) and Microsoft Excel application over 60 years from 1961 to 2020, utilizing ERA5 data. The time frame is divided into two periods: 1961-1990 and 1991-2020, aiming to observe rainfall characteristics such as changes, patterns, and trends that occurred during these intervals. The highest monthly average rainfall occurs in January for both periods, registering 378 mm for 1961-1990 and 370 mm for 1990-2020. In contrast, the lowest monthly average occurs in August, with values of 51 mm for 1961-1990 and 38 mm for 1991-2020. The highest seasonal average rainfall occurs during the DJF period, with values of 945 mm for 1961-1990 and 1022 mm for 1991-2020. However, the lowest seasonal average occurs during the JJA period, with values of 228 mm for 1961-1990 and 191 mm for 1991-2020. The rainfall trend shows an increase for the first period (1961-1990), whereas decreases in the second period (1991-2020), including wet seasons, dry seasons, and annual. The result can be associated with climate change, where there are occurrences of extremely wet and extremely dry seasons. Overall, the Special Region of Yogyakarta province experienced continuous yearly rainfall from 1961 to 2020.
Sintesis Hidroksiapatit Berbahan Tulang Ikan Layar (Istiophorus Platypterus) Menggunakan Metode Presipitasi
Authors: Al-Qarny Uwais , Rauf Nurlaela
Published: February 2025

Tulang ikan layar merupakan salah satu limbah hayati laut yang berpotensi sebagai sumber hidroksiapatit untuk aplikasi biomedis. Penelitian ini bertujuan untuk mensintesis hidroksiapatit berbahan tulang ikan layar melalui metode presipitasi dengan pengaruh variasi massa prekursor kalsium dan konsentrasi prekursor fosfat. Tulang ikan layar dikalsinasi pada suhu 900ºC selama 3 jam, kemudian direaksikan dengan (NH4)2HPO4. Larutan diatur pada pH 8 menggunakan NaOH, diendapkan selama 24 jam pada suhu kamar untuk menghasilkan endapan yang homogen, dicuci dengan akuades, dan disaring. Endapan kemudian dikeringkan pada suhu 100ºC selama 2 jam untuk menghasilkan hidroksiapatit. Karakterisasi FTIR menunjukkan keberadaan gugus PO43-, OH-, dan CO32- pada ketiga sampel. Sampel C memiliki intensitas absorpsi gugus PO43- dan OH- yang lebih tinggi dibandingkan kedua sampel lainnya. Semakin tinggi intensitas absorpsinya, maka semakin banyak kandungan gugus PO43- dan OH-. Analisis XRD menunjukkan bahwa ketiga sampel memiliki fase hidroksiapatit yang dominan. Selain fase hidroksiapatit, terdapat juga fase apatit karbonat tipe A dan fase apatit karbonat tipe B. Sampel C memiliki rerata ukuran kristal terbesar, yakni 28,94 nm
Notes on the Origin of Several Textemes in the Work of I.L. Caragiale
Authors: Terian Simina-Maria
Published: February 2025

This article demonstrates that some of the textemes of Romanian playwright I.L. Caragiale, which later became famous throughout the entire Romanian ethnolinguistic community, are in fact borrowed from older Romanian texts, which appeared in the mid-19th century. My analysis focuses on three textemes from Caragiale’s comedies (“the family is the small homeland, as the homeland is the large family”, “a stormy night” and “have a little patience”), identifying their origins in the writings of C. D. Aricescu, Ioan M. Bujoreanu and I. Heliade-Rădulescu. My study concludes that Caragiale’s plays have a deeply intertextual structure.
Towards an Operational Didactic Model: From Teaching-Learning Legal French to Translating and Writing Specialized Texts
Authors: Brad Rodica
Published: February 2025

The aim of the present study is to discuss, both theoretically and practically, based on my experience as a professor at the MA in The Theory and Practice of Translation, the opportunity and the necessity of an operational model in the didactic approach to specialized translation, as part of the specialized language teaching framework in a multilingual environment. Such an approach has to be based on a complex and integrative pedagogy, which can accommodate the numerous challenges encountered in the training process of translators, who are increasingly expected to master knowledge and different means of expression related to the specialized knowledge of other areas of activity, particularly law. Taking this into consideration, I aim to demonstrate the advantages of such an integrative approach through a four-stage teaching-learning process on legal discourse, namely teaching-learning legal discourse and its characteristics, analyzing legal texts, translating and preparing professional legal texts. In order to illustrate this approach, I outline the most important aspects of these four didactic stages, while focusing on the strategies related to the specificity of legal discourse and the theoretical challenges arising from current research in the field. Moreover, my study brings to the fore the main challenges of teaching specialized languages and specialized discourse analysis, but also of writing legal texts and other specialized professional papers.
Emotional Dynamics in Convorbiri literare — A Quantitative Analyis of 32 Years of Poetry Using Sentiment Analysis
Authors: Susarenco Teodora
Published: February 2025

This article explores the area of sentiment analysis, specifically looking at its use on a special dataset: poems published in Convorbiri Literare from 1867 to 1898. With a focused approach, the study examines the detailed expressions of happiness and sadness within this 32-year collection, using advanced sentiment analysis techniques to understand the emotional nuances present in the poetry of that period. The research leads the way in applying both traditional and innovative sentiment analysis methods, including lexical affinity, concept-level analysis and clustering methods, to analyze the emotional content of the poems. By tracking the changes in emotional expressions of happiness and sadness over three decades, the study showcases the change in sentiment in poetry, reflecting cultural shifts and artistic movements of the time. The findings not only reveal the emotional dynamics of 19th-century Romanian poetry but also set the stage for future research, particularly in the realm of quantitative literary analysis.
Eine neue Bildungspolitik für eine Welt im Umbruch
Authors: Plünnecke Axel
Published: February 2025

Germany faces challenges of demographics, decarbonisation, digitisation and deglobalisation. Innovative strength and securing skilled labour are crucial, but Germany is losing strength in research and patents. Demographic problems and declining STEM skills are exacerbating the situation. Immigration partly compensates for this, but the education system is not utilising the potential, especially among children from educationally disadvantaged households. What is needed is more STEM education, all-day school programmes, language support, more research spending at universities and more teaching capacity for international students. Federal policy should implement a quality package for early childhood education, an expansion of the “Startchancen” programme, a national STEM action plan and an additional digital pact.
Der Weg zu mehr Wirkungsorientierung im Bundeshaushalt
Authors: Heinemann Friedrich
Published: February 2025

In international comparison, Germany is considered a latecomer when it comes to performance budgeting. After clarifying the central concepts of goal- and impact-oriented budgeting and its historical foundations, the article describes the progress that the federal government has made since the 2000s towards a more impact-oriented management of its funds. For example, there is a regular evaluation obligation, in which comprehensive spending reviews are carried out and top-down budgeting strengthens the responsibility of the ministries for the targeted use of funds. Nevertheless, there are still numerous obstacles to overcome in order to catch up with the pioneers of performance budgeting. This article shows how a broadly conceived package of measures could strengthen impact orientation in the coming years. We recommend that the next government coalition make committed use of this set of instruments to leverage efficiency reserves in the federal budget.
Welche Unterstützung junge Menschen bei Unternehmensgründungen wichtig finden
Authors: Andrade Ivo , Bürger Tobias
Published: February 2025

Entrepreneurial activity among young people in Germany remains low, thereby limiting Germany’s future innovation potential. A conjoint analysis of 297 young entrepreneurial-minded individuals identifies financial support – such as a start-up basic income and access to venture capital – as the most effective measures for increasing the attractiveness of youth entrepreneurship besides networking, mentoring and educational offers. Targeted supporting measures could help activate an untapped entrepreneurial potential and strengthen the entrepreneurial ecosystem.
BUILDING INTERNAL INNOVATION CAPACITY IN LARGE ENTERPRISES: A STRATEGIC IMPERATIVE
Authors: POPESCU-ZORICA Alexandra
Published: February 2025

This paper explores the necessity for large enterprises to develop robust internal innovation capabilities as a strategic imperative for sustaining long-term competitiveness. While 83% of global companies prioritize innovation, only 3% demonstrate high innovation readiness, highlighting a gap between ambition and execution. The study employs a literature review and case study analysis to examine the structural and cultural barriers that hinder corporate innovation, including risk aversion, hierarchical decision-making, and a focus on operational efficiency over exploration. The research further evaluates leading innovation governance models, including Deschamps & Nelson’s governance structures and Brouwer’s hierarchical, market-driven, and hybrid models, as well as practical innovation frameworks such as the Ambidextrous Organization Model and Doblin’s Ten Types of Innovation. The findings suggest that companies must move beyond incremental improvements and acquisitions by implementing adaptive governance structures, cross-functional collaboration, and long-term strategic foresight. The paper identifies a set of best practices for developing innovation capacity, including the integration of intrapreneurship programs, AI-driven innovation, open innovation partnerships, and agile methodologies. The research concludes that organizations achieving a balance between governance structure, innovation frameworks, and strategic adaptability outperform competitors in growth and resilience. Recommendations include establishing leadership commitment, aligning innovation efforts with corporate strategy, and fostering a culture of experimentation to drive long-term business success.
A REFERENCE MODEL FOR BUSINESS ANALYTICS-BASED DECISION-MAKING PROCESSES IN RAIL TRANSPORT MANUFACTURING COMPANIES IN SOUTH AFRICA
Authors: BAKAM Genevieve , MPOFU Khumbulani , MBOHWA Charles
Published: February 2025

In addition to digital transformation, businesses have reviewed their business strategies and decision-making techniques to develop a competitive advantage in the transport manufacturing sector. It happens that innovative business approaches face some limitations compromising business survival in the long term. This study investigates the importance of adopting a reference model for business analytics-based decision-making processes in rail transport manufacturing companies. This study follows a qualitative research design using secondary data published in various annual reports to define the thematic analysis around descriptive, prescriptive, and predictive analytics for enhanced business analytics-based decision-making solutions. Results indicate that improved business decisions should be based on the combination of company strategies, technology innovation and business analytics techniques for goals alignment, innovative solutions and data visualisation. Additionally, descriptive, prescriptive, and predictive analytics are generated in a predefined format to suit business, socioeconomic and environmental requirements like product localisation, company equity, financial support of black businesses, skills development, local community empowerment, and environmental protection. Business analytics-based decisions enable cost control, differentiated business decisions for competitive advantage, and strategy upgrades in addition to customer satisfaction, profitability growth and long-term sustainability. The proposed reference model shows the link between company strategies, data analysis, and technology impact in generating enhanced analytics powering the decision-making process in transport manufacturing to ensure the revitalisation of future transport in South Africa. Recommendations highlight that the South African government should improve technology infrastructure and skills development to limit resistance to digital transformation enabling business analytics.
Role of volumetric CT perfusion of the liver in portal hypertension considering the level of portal circulation blocking: a prospective study
Authors: Djuraeva N. M. , Vakhidova N. T. , Amirkhamzaev A. T. , Abdukhalimova Kh. V. , Sultanov A. T. , Khursanova D. Kh. , Mirtadzhieva Z. D. , Magzumova S. Kh.
Published: February 2025

Relevance. Modern studies focus on the analysis of hemodynamic changes in the liver in diffuse pathologies, as well as the role of mechanisms that increase arterial perfusion with a decrease in portal blood flow. Diffuse liver diseases eventually lead to fibrosis and the risk of cirrhosis, but invasive biopsy remains the only accurate method for staging. Non-invasive methods such as elastography and the Child–Pugh scale help assess the severity of liver cirrhosis. Perfusion CT (PCT) allows you to determine the functional state of hepatocytes and determine their microcirculation. The method is safe, has a high resolution and provides complex parameters of liver perfusion. Wide-detector CT allows you to level out various artifacts, obtain perfusion images of the liver in a single scan and expand the diagnostic capabilities of this technique.

The aim: to evaluate the diagnostic effectiveness of volumetric perfusion CT in determining the severity of hemodynamic disorders in patients with portal hypertension (PH), taking into account the level of blockage of the portal circulation.

Materials and methods.The prospective study involved 110 patients divided into four groups: 63 patients with liver cirrhosis (LC) (block at the level of the intrahepatic postsinusoidal circulation); 10 patients with liver fibrosis (LF) (block at the level of intrahepatic presinusoidal circulation); 13 patients with PH of extrahepatic etiology (block at the level of the subhepatic circulation), 24 patients in the control group, donors of the liver fragment. The study assessed liver perfusion parameters such as arterial perfusion (AP), portal perfusion (PP) and hepatic perfusion index (HPI).

Results. The most pronounced deviations in liver perfusion were verified in subhepatic block (SHB), with a significant increase in the liver index (35.6 ± 1.5%; p < 0.001). In cirrhosis with postsinusoidal block, there was a significant decrease in the portal fraction, a compensatory increase in arterial blood flow to 41.4 ± 0.7 ml/100 ml/min and, accordingly, a higher increase in the liver index (23.8 ± 0.4%; p < 0.001). Paradoxical changes in perfusion parameters with the formation of a hyperkinetic type of blood circulation and an increase in portal blood flow relative to normative values up to 169.4 ± 5.0 ml/100 ml/min (p < 0.01) were obtained in AF.

Conclusion. The results confirm the diagnostic effectiveness of volumetric CT perfusion and its significance in assessing and predicting the severity of hemodynamic disorders in patients, taking into account the level of blockage of the portal circulation.
Reduced myelination of white matter in patients with affective disorders according to fast macromolecular proton fraction mapping
Authors: Borodina S. O. , Burenkova M. G. , Borodin O. Y. , Smirnova L. P. , Epimahova E. V. , Yarnykh V. L.
Published: February 2025

Abstract. This study aimed to test the method of fast molecular proton fraction mapping as a tool for quantitative assessment of myelin deficiency in affective disorders between general and local measurements in seven selected regions of interest of both hemispheres in comparison with the control group, determining the sensitivity and specificity of the method.

Materials and methods. The study included 24 patients with affective disorders, 13 were diagnosed with a current depressive episode as part of recurrent depressive disorder, and 11 were diagnosed with bipolar affective disorder. All patients underwent non-contrast magnetic resonance imaging of the brain using a fast MPF mapping protocol. Comparison of the MPF levels for the control and experimental groups were calculated using the Mann-Whitney U-test. ROC analysis was used to assess the prognostic value of the investigating parameters.

Results. The average MPF indices of all selected regions of interest for the control group and group of patients with affective disorders (AD) were significantly different (p < 0.0001). In a pairwise comparison of each selected area, patients with AD showed a significant decrease in MPF in all selected areas of white matter compared to the control group (p < 0.05). Analyzing the ROC curves, the largest areas under the ROC curves (AUC) were 0.892 ± 0.061 (83.3%; 88.89%) and 0.888 ± 0.054 (70.83%; 83.3%) in the periventricular zone and thalamic area respectively. which indicates the “high” information content of these models for detecting the process of hypomyelination in patients with AR.

Conclusion. Affective disorders are characterized by a significant decrease in the MPF of the white matter of the brain in comparison with the control group (p < 0.05), which indicates a decrease in the concentration of myelin in the observed areas. The process of hypomyelination is diffuse as it was significantly expressed in all selected regions of interest in patients with affective disorders, including the periventricular zone and the area of thalamus and basal ganglia in comparison with controls (p < 0.05). MPF changes in the periventricular zone have the greatest diagnostic value for detecting hypomyelination in AD (PPV = 91%, NPV = 80%).
Assessment of the informativeness of ultrasonography for determination of the volume of hemoperitoneum in children
Authors: Pikalo I. A. , Podkamenev V. V. , Karabinskaya O. A. , Marchenko D. V. , Akudovich N. V. , Mikhailov N. I. , Sharapov I. S.
Published: February 2025

In the field of pediatric trauma, the question of the optimal approach to diagnosing the volume of hemoperitoneum and calculating blood loss in injuries to the abdominal organs is of important clinical significance.

Aim. To develop an ultrasound diagnostic method to accurately determine the volume of free fluid in the abdominal cavity and study its informative value in children with hemoperitoneum.

Material and methods. To calculate the volume of free fluid during echosonography, an experiment was conducted on cadaver material (10 victims). To simulate hydroperitoneum, a drainage was installed in the epigastrium using a puncture method, through which an isotonic solution was injected into the peritoneal cavity in portions. Subsequently, ultrasound was performed and correction factors were calculated. The assessment of the informativeness of the ultrasound diagnostic method was carried out based on the results of a one-time analysis of 47 case histories of patients with splenic rupture and hemoperitoneum who were treated from January 1997 to September 2009.

Results. In an experiment on cadaver material, a comparison between the true volume and the obtained volume according to echosonography revealed a significant (p = 0.008) difference of 400 (100; 600) ml and 139 (21; 355) ml, respectively. To optimize the calculation of the volume of free fluid according to ultrasound data, correction factors were calculated, which were 2.36 for low hydroperitoneum (up to 11 ml/kg); 1.37 for moderate (11–22 ml/kg) and 1.04 for large (more than 22 ml/kg). In the clinical group, the information content of ultrasound was assessed using the obtained correction factors and body surface area. It was revealed that the resulting formula has high diagnostic tests (sensitivity 93–100%; specificity 88.2–97.7%) for the true calculation of hemoperitoneum volume in children.

Conclusion. In children, when performing abdominal echosonography using correction factors, it is possible to calculate with high accuracy the true volume of bloodshed, which is necessary for assessing blood loss. Our results allow us to contribute to the optimization of diagnostic procedures and improve our understanding in assessing the exact volume of hemoperitoneum in the context of abdominal injuries.
Medical imaging and artificial intelligence in radiotherapy of malignant tumors
Authors: Panshin G. A. , Nudnov N. V.
Published: February 2025

The fusion of artificial intelligence with medical imaging is undoubtedly a progressive innovative process in the modern development of domestic healthcare, which allows for unprecedented accuracy and efficiency in the diagnosis and planning of special treatment of various diseases, including malignant tumors. At the same time, artificial intelligence approaches, especially in the field of clinical application of radiotherapy techniques, are spreading more widely and moving from the field of specialized research to the field of already accepted traditional clinical practice.

Purpose of the study: to analyze the approaches of artificial intelligence in the field of clinical application of radiotherapy techniques for the antitumor treatment of malignant tumors.

Conclusion. The further development of artificial intelligence provides for the provision of options for the prevention, diagnosis and treatment of cancer patients against the background of a constant increase in accuracy in their implementation, including assistance in optimizing radiotherapeutic treatment of malignant neoplasms.
PERAN BRAND IMAGE MEMEDIASI PENGARUH KREDIBILITAS CELEBRITY ENDORSER TERHADAP PURCHASE INTENTION
Authors: Weking Maria Margaretha Annisa Prameswari , Oktora P I Gede Nandya
Published: February 2025

Bisnis yang berkembang pada perusahaan masa kini menawarkan produk berkualitas melalui promosi menarik dengan menggunakan celebrity endorser guna memperkuat ingatan konsumen mengenai brand image produk sehingga akan menarik perhatian calon konsumen untuk memiliki minat beli. Penelitian ini bertujuan untuk menjelaskan peran brand image sebagai mediasi pada pengaruh kredibilitas celebrity endorser terhadap purchase intention. Penelitian ini dilakukan pada calon konsumen di Kota Denpasar yang belum pernah membeli produk kopi Good Day dengan ukuran sampel 110 orang. Pengumpulan data melalui kuisioner dalam bentuk google form. Teknik analisis menggunakan path analysis dan uji sobel dengan bantuan program SPSS for windows. Hasil penelitian menunjukkan bahwa kredibilitas celebrity endorser berpengaruh positif dan signifikan terhadap brand image. Kredibilitas celebrity endorser dan brand image berpengaruh positif dan signifikan terhadap purchase intention. Brand image secara signifikan memediasi pengaruh kredibilitas celebrity endorser terhadap purchase intention.
Pengaruh Komunikasi Organisasi Terhadap Kinerja Gardener: Studi Kasus The Oberoi Beach and Resort Bali
Authors: Aprilia Kusumawardhani Awanda Vyta , Kohdrata Naniek , Jelantik Anak Agung Ayu Wulandira Sawitri
Published: February 2025

The Effect of Organization Communication on Gardener Performances: A Case Study at The Oberoi Beach and Resort Bali. This research aims to analyze and describe the significant influence of organizational communication and suitability of organizational communication within The Oberoi Beach and Resort Bali, specifically for the garden maintenance work organizational structure. The population sample in this research were the gardeners at The Oberoi Beach and Resort Bali. The method used in this research is the Partial Least Squares (PLS). As an alternative method of Stuctural Equation Modeling (SEM), the PLS can be used to determine how much the independent variable influence the dependent variable. The result shows that the downward communication significant negatively affect on the gardener performance, however upward communication and horizontal communication show positive significant affect to the gardeners performance.
Evaluasi Aspek Lanskap Ramah Lansia pada Lapangan Puputan Margarana Renon, Denpasar-Bali
Authors: Darung Jackobus Julindro , Semarajaya Cokorda Gede Alit , Krisnandika Anak Agung Keswari
Published: February 2025

Abstract
Evaluation Of Eldery-Friendly Aspect In Puputan Margarana Field Renon. City parks are public open spaces that can be used to conduct various kinds of activities. Therefore, good city parks should be designed to be suitable to elderly people who have physical limitations. The purpose of this study is to identify the landscape criteria for elderly-friendly parks and evaluate the compatibility of the elderly-friendly aspects of the city parks according to the compiled criteria. This study uses a survey method with descriptive and quantitative analysis data collection techniques using the KPI (Key Performance Index) method. The assessment of this study are divided into 4 (four) assessment indicators, which are : location, accessibility, vegetation and facilities. The results of the study shows that vegetation is the indicator with the highest rating and accessibility is the indicator with the lowest values. Overall, the selected city parks are quite friendly to the elderly, but several aspects need to be considered to make the parks more friendly to the elderly.
 
Keyword: Accessibillity, Facilities Location, Vegetation
Konsep Desain Rurung Sebagai Ruang Terbuka Multifungsi Studi Kasus: Koridor Jalan Karna, Kelurahan Ubud, Gianyar, Bali
Authors: Krispariyana Cokorda Alit , Semarajaya Cokorda Gede Alit , Sukewijaya I Made
Published: February 2025

The Jalan Karna Ubud Corridor is classified as an environmental road that is commonly known as a means of connecting the community with the surrounding space. Along with its development, the road corridor underwent many changes, which caused the comfort and function of this road corridor to be reduced. The purpose of this study is to produce a rurung design concept that can accommodate community activities as a multifunctional facility in the community environment, as well as describe the phenomenon of the rurung space as a multifunctional space. The research method used is a survey method with the data collection process using observation, questionnaires, interviews, and literature studies. The basic concept developed is space as a multifunctional space, namely the application of the concept of open space in order to facilitate various community activities carried out in that space. Thus, it is hoped that the presence of a road corridor as a multi-functional space in facilitating community activities will be able to provide a sense of balance with the balance of needs between users who have differences in each individual community. It is also hoped that the existence of this road corridor can become an icon or distinctive and, at the same time, can become a feature or example in other areas of Bali.
Studi Perubahan Pola Ruang Pesanggrahan Ambarrukmo Yogyakarta Tahun 2004 - 2021
Authors: Tyas Paula Nugraheni , Kohdrata Naniek , Bawono Rochtri Agung
Published: February 2025

Pesanggrahan Ambarrukmo is one of the historical legacies of the Keraton Yogyakarta which has a unique spatial pattern, historical and socio-cultural value. As a heritage building, it faces physical changes following the construction of the Ambarrukmo Plaza and the Royal Ambarrukmo Hotel’s renovation. This study aims to determine the changes in spatial patterns before and after the construction of Ambarrukmo Plaza and the renovation of the Royal Ambarrukmo Hotel (2004 - 2021). The research method in this study is qualitative with a cultural studies approach and the triangulation methods in the form of interviews, observations and documentation combined with literature study. Physical changes occurring in Pesanggrahan Ambarrukmo have reduced the semi-sacred and profane areas as well as profane areas’ open green spaces, while the sacred area is not affected. Plaza Ambarrukmo and Hotel Royal Ambarrukmo managed to be a buffer space for Pesanggrahan Ambarrukmo. The changes of Pesanggrahan Ambarrukmo as an effort to maintain its existence are the most appropriate way in this modern era. The role of the managements, government, and community are necessary to preserve Pesanggrahan Ambarrukmo.
Konsep Desain Healing Garden bagi Pasien Penyakit Jantung di Rumah Sakit Angkatan Darat Udayana Denpasar, Bali
Authors: Safitri Nia , Krisnandika Anak Agung Keswari , Dharmadiatmika I Made Agus
Published: February 2025

Design of the Hospital Garden as a Healing Garden in Udayana Hospital for Heart Disease Patient. Heart disease is a disease with the highest risk of death in Indonesia. Healing heart disease can be done medically and can be done in an outdoor room with a healing garden which has cardiac therapy facilities in it to accelerate the healing process for patients and reduce patient stressors. So that environmental factors have an important role in the patient's healing process, but in reality the importance of the garden as a place of healing is ignored. In fact, a good garden design arrangement will help heal patients physically and non-physically. The purpose of this research is to produce a garden design concept that can support the healing of heart disease patients at Udayana Hospital. The concept applied to the hospital garden is the design concept of the healing garden Biomimicry. The research method used is a survey method with data collection techniques through observation, interviews, and literature study. The stages of the research carried out include inventory, analysis, synthesis, and design concept planning. The design concept is designed based on the needs of heart disease patients in their recovery period by paying attention to softscape and hardscape. The design concept of Biomimicry contains the philosophy of freedom, this is related to the space for physical movement, with freedom in physical movement, the healing process of heart disease patients will be faster physically and psychologically.
Perancangan Taman Vertikal Pada Dinding Underpass Simpang Tugu I Gusti Ngurah Rai
Authors: Pane Radius , Sugianthara Anak Agung Gede , Dharmadiatmika I Made Agus
Published: February 2025

The increase in physical development in urban areas is in line with the increase in air pollution. The process of burning gas from the exhaust can pollute the air up to about 60% of other air pollutant factors. Air pollution that is commonly found in urban areas is Nitrogen Oxides (NOx). Nitrogen oxides (NOx) are chemical compounds of oxygen and nitrogen that are formed from combustion at high temperatures, especially the combustion of fuels that are responsible for the smog and brown clouds that cover large cities and produce poor air quality and cause serious health effects serious in humans. One way to overcome the problem of air pollution in urban areas with narrow land, is to plant a vertical garden model of road plants. Vertical garden is a landscaping business by utilizing land as much as possible, by utilizing the potential of vertical walls in the area so that the number of plants per unit area is more. The purpose of writing this paper is to see the potential application of the concept of vertical gardens on the underpass wall by optimizing the potential and overcoming obstacles in the path of the Simpang Tugu I Gusti Ngurah Rai underpass. The research method used is a survey method with data collection techniques through observation, interviews, and literature studies. The results showed that the underpass wall can be installed with a vertical garden with a structural truss method that is attached to the underpass wall and using a drip irrigation system controlled by a timer for watering and fertilizing. And the results of the vegetation design using shrubs that are able to neutralize nitrogen oxides (NOx), namely Es lilin hijau (Chlorophytum bichetii), Kriminil hijau (Alternanthera ficoida) and Taiwan beauty (Cuphea hyssophylla). For the design of the vertical garden planting pattern, it will follow the stylized form of the Mas-Mas Keketusan Ornament.
Analysis of Disease Free Survival and Overall Survival of HER2 Positive Subtype Breast Cancer Patients at Prof. Dr. I.G.N.G. Ngoerah Denpasar Hospital
Authors: Kamajaya Gde Ary Putra , Wetan Ni Gusti Ayu Agung Manik Yuniawaty , Setiawan I Gede Budhi
Published: February 2025

Aim: This study aim to assess the characteristics of the patients, as well as the 3-year and 5-year overall survival and disease free survival of HER2+ breast cancer patients treated at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar Methods: This retrospective cohort study assessed survival rates and prognostic factors among HER2+ breast cancer patients treated at Prof. Dr. I.G.N.G. Ngoerah Hospital Denpasar from January 2017 to December 2022. The study used medical records to examine variables such as age, tumor characteristics, metastasis patterns, histology, treatments, and survival outcomes over 3- and 5-year periods. Results: The 3-year survival rate was 77.7% and the 5-year survival rate was 74.3%, with median survival times of 31 months (95%CI 30.7-32.86) and 49 months (95%CI 47.85-52.089), respectively. Disease-free survival rates indicated median durations of 33 months (95%CI 32.949-34.545) at 3 years and 54 months (95% CI 53.063-56.357) at 5 years. Conclusion: This study enhances understanding of HER2+ breast cancer prognosis, emphasizing the critical roles of lymph node status, metastatic burden, and treatment strategies in determining patient outcomes.