bluuebunny/crossref_metadata_2025 huggingface dataset:
Face parsing and blending-based analysis model for makeup style transfer
Authors: Wang Xiaofeng , Zhang YiChen , Han Tianbo , Liu Wei , Liu Songling , Zhang Yongqin , Liu Yonghuai
Published: December 2024

Makeup is a fundamental element of traditional opera culture, embodying profound artistic connotations and aesthetic values. Incorporating patterns and decorative elements into makeup has also become an essential aspect of contemporary society. Makeup transfer technology enables the reproduction of existing makeup designs onto specified facial images. However, current methodologies face several challenges, including incomplete pattern replication and suboptimal results, particularly in transferring patterned makeup. Consequently, this paper proposes a novel makeup transfer model, termed Opera-MT, which integrates facial parsing with image-fusion techniques. The Opera-MT model first maps facial images onto UV space to establish a pixel-accurate correspondence between the reference face and the source face, effectively addressing issues related to pattern distortion. Subsequently, it integrates facial parsing techniques with Poisson image fusion methods to preserve the texture details of the pattern, thereby overcoming the challenge of incomplete pattern migration in the reference makeup. Finally, the model utilizes a color transfer network to apply the color style of the reference makeup to the source face, resulting in the final output. The effectiveness of Opera-MT has been validated on three datasets, including our collected PM dataset and two publicly available datasets, namely the MT and makeup datasets. The results demonstrate that Opera-MT successfully captures makeup color and pattern texture, producing high-quality, realistic, and natural results. Our code will be available at https://github.com/xiaozhang0927/Opera-MT.
Melittin induces apoptosis, Mitochondrial membrane potential, Reactive Oxygen species, and cell cycle arrest against T-cell acute lymphoblastic leukemia (T-ALL) in vitro.
Authors: Kumar Ajeet , Tilak Vijai , Raju S.V.S , Ali Akhtar
Published: December 2024

Acute lymphoblastic leukemia originating from early T-cell progenitors is called T-cell acute lymphoblastic leukemia (T-ALL). Chemoresistant T-ALL cancer is gaining interest in less hazardous drugs and therapy. These days, pyrimidine and phytochemical analogs have unique qualities that can be used to develop novel medications. Research has shown that melittin has cytotoxic effects on cancer, however, these effects are yet unclear. Our present study aims to evaluate melittin’s ability to induce apoptosis in Acute lymphoblastic leukemia cells. Our goal was to find out how Melittin affected the DNA fragmentation test, hemolytic assay, reactive oxygen species, cell proliferation, and apoptosis in Jurkat cells. The effects of Melittin on apoptosis were examined using propidium iodide and acridine orange. The effects of Melittin on cell viability were determined by (3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) MTT assay for 24–48 h. Using MTT, we assessed Melittin's cytotoxic activity on Jurkat cells and established the drug's IC50 value (1µg/mL). Melittin suppressed the growth of Jurkat cells in a dose-dependent manner, as the results demonstrate. Melittin promoted pro-apoptotic genes and downregulated anti-apoptotic ones to cause apoptosis. Our findings demonstrated that different doses of Melittin decreased cell viability in Jurkat cells, cell cycle arrest in G2-M Phase, Annexin-V PI apoptosis in late apoptotic and Mitochondrial membrane potential decrease in Rh-123 fluorescence intensity indicates disrupted membrane potential compared to the control. According to our research, melittin may be an effective anti-tumor agent in ALL by inhibiting the induction of apoptosis and reducing antioxidant levels in Jurkat cells.
Biobibliographical Works of Galen as a Source for the History of Roman Book Culture
Authors:   Russian University of Medicine, Prolygina Irina
Published: December 2024

The article examines the problems of book culture in Rome in the 2nd-3rd centuries AD according to new
historical and philological evidence from the bio-bibliographical works of Galen. After the publication of new critical editions of his works De libris propriis and De indolentia, new evidences on Roman libraries, their topography,
book collections, the state of manuscript funds, as well as on Galen’s work as a philologist, editor and text critic
were introduced into scientifi c circulation. The purpose of the article is to show that Galen was not only a famous
physician and philosopher but also one of the outstanding scholars of his time, who was inextricably linked with
the culture of the “Second Sophistry”. The continuity of the Greek intellectual tradition and education, the interest
in the works of medical and philosophical authorities, the copying and reconstruction of their texts both for personal needs and for public use and the preservation of cultural heritage, as evidenced by Galen, largely clarify
the issues of cultural life in Rome at that time and Galen’s place in it. The research methodology is based on
traditional historical and philological analysis and source study of Galen’s original Greek texts, which are considered against the background of the cultural tradition with the study of relevant terms and concepts necessary
for its characterization. The results of the study clarify a number of philological issues in the fi eld of book history,
libraries, philological terminology of text criticism and cultural studies and can be used in various philological,
historical and cultural studies courses.
Information-Mental and Socio-Evolutionary Contexts of the Dynamics of War and Peace
Authors:   Institute of Philosophy and Law, Siberian Branch, Russian Academy of Sciences, Rozov Nikolai
Published: December 2024

The fi rst decades of the XXI century are marked by processes of turbulence, multiple tensions and dramatic
events. In this context, the issues of geopolitics, war and peace play a particularly signifi cant role. On the basis of
synthesis and clarifi cation of fundamental concepts and principles of social anthropology, psychology, sociology,
political sciences, we present a holistic dynamic model of factors of emergence, escalation and termination of
wars, and their macro-social consequences. Taking into account these provisions, we provide theoretical answers to fundamental questions about the causes of war. The study is based on the following methods: analysis
and synthesis, conceptual study of basic concepts from different spheres of social and humanitarian knowledge,
formulation and substantiation of fundamental principles of war and peace dynamics, theoretical comprehension
of heterogeneous empirical generalizations. Wars are always related to concerns and social universals: violence/
security, power-power, resources-wealth, and prestige-legitimacy. At the same time, wars are triply related to
information, cognitive processes, and, in the modern world, new media and propaganda technologies. Powerful decisions on the use of military force, leading to wars, are made on the basis of “fast” or “slow” thinking according
to Kahneman. The course of war itself, apart from the “material” component of mobilization and mutual destruction, always includes a struggle of wills – attempts by each side to impose a ritual scenario of the inevitability
of its defeat on the enemy. The outcome of the war is always the subject of a struggle of interpretations and
narratives on the part of the strongest post-war political-ideological forces. The specifi c role of war in the co-evolution of social, mental and techno-natural orders is presented with these provisions in mind. The constructed
conceptual apparatus, formulated principles and ideas of the holistic dynamic model of the emergence, course
and termination of wars are intended for deeper theoretical and empirical research in this important and relevant
subject area. In addition, they should contribute to the analysis, design and implementation of such objective and
subjective conditions that will not ensure the proverbial “eternal peace”, but will minimize the factors of new wars.
Estudo da qualidade de vida e da depressão em pessoas portadoras de vitiligo: uma análise baseada em um questionário de autoavaliação
Authors: Passos Leonardo Paes Landim , Issegue Leo Kenyo , Baeta Raquel de Souza , Almeida Eduardo Henrique Graciano , Rodrigues Gustavo de Pinho Barbosa , Romero Frederico Gerlinger , Dobgenski Mirella Cristina Pereira Polonio
Published: December 2024

Objetivo: Analisar o desenvolvimento psicossocial e a qualidade de vida em pacientes com vitiligo, assim como também a prevalência de depressão e de alterações nos índices de qualidade de vida em diferentes grupos de adultos. Métodos: Coleta de dados de voluntários através de redes sociais por meio de formulários pré-estabelecidos com perguntas relevantes para possíveis impactos na área temática explorada. Os dados coletados serão analisados por meio de estatísticas descritivas. Além disso, foi feito um levantamento bibliográfico nos bancos de dados PubMed e Google Acadêmicos, aplicando critérios de inclusão (artigos dos últimos 5 anos) e exclusão (retirar revisões de literatura) na seleção dos artigos para a introdução da temática deste artigo e comparação dos resultados. Resultados: 71% dos participantes da pesquisa portadores de vitiligo tiveram alterações na qualidade de vida, e 76% tiveram possível ansiedade ou depressão (score de 12 a 21 pontos) Conclusão: Falta-se dados para comparar os números com a literatura, porém, o estudo mostrou uma influência, mesmo que de forma leve, do vitiligo com a qualidade de vida. Tal influência foi pequena na relação com a depressão.
MUSA PARADISIACA (KADALI) PSEUDOSTEM AS A POTENT NUTRACEUTICAL IN KIDNEY DISORDERS- A REVIEW
Authors: V.S Nimmy
Published: December 2024

Musa paradisiaca, is a tropical plant widely recognized for its nutritional and medicinal properties. While the fruit is celebrated for its carbohydrate-rich composition and essential vitamins, the pseudostem-often treated as agricultural waste-has garnered attention for its remarkable therapeutic potential. This review compiles and critically analyzes current evidence on the pharmacological effects of the banana pseudostem, emphasizing its role as a nutraceutical in managing diseases such as urolithiasis, diabetes, and nephropathy. The pseudostem exhibits anti-inflammatory, diuretic, anti-urolithiatic, and nephroprotective properties, with studies demonstrating its ability to reduce stone-forming markers, such as glycollic acid oxidase and lactate dehydrogenase, while preventing kidney stone deposition. In diabetes management, the pseudostem shows anti-hyperglycemic effects by modulating advanced glycation end-products and improving kidney function, positioning it as a potential plant-based alternative for diabetic nephropathy. Furthermore, its nutraceutical applications extend to the development of functional foods and supplements, leveraging its rich nutritional profile of carbohydrates, fiber, protein, and essential minerals. By transforming the pseudostem from an underutilized byproduct into a valuable resource, Musa paradisiaca offers sustainable solutions for healthcare and agriculture. This review underscores the pseudostems potential in Ayurveda medicine, advocating its inclusion in dietary regimens and therapeutic formulations to address chronic conditions effectively.
COMPARATIVE STUDY OF PROPOFOL AUTO-COINDUCTION VERSUS KETAMINE PROPOFOL COINDUCTION USING PRIMING PRINCIPLE BY BISPECTRAL INDEX ANALYSIS FOR DAY CARE SURGERY
Authors: Chawla Davinder , Goyal Reiya , Kumar Parmod , Kaur Mandeep
Published: December 2024

Aim:The aim of our study was to do the comparison of Propofol Auto-coinduction versus Ketamine Propofol coinduction using priming principle by bispectral index analysis for day care surgery.

Methods:150 patients participated in our study at Govt. Medical College and Rajindra Hospital, Patiala. Patients aged above 18 years and ASA Grade I and II scheduled to undergo elective surgery were included in this prospective, randomized controlled trial. All patients were randomly assigned into 3 groups of 50 each. Group A- patients were given Propofol 0.5mg/kg body wt., Group B- patients were given Ketamine 0.5mg/kg body wt., Group C- patients were given normal saline 2.5ml 2 minutes before induction. Patients were induced with injection Propofol 1% at rate of 30mg/10 sec until BIS value reaches to 40. Induction dose requirements of Propofol, Haemodynamic parameters including HR, MAP, SBP, DBP,SPO2, ECG, RR were recorded. Incidence of post op complications / side effects were also recorded. Data was tabulated and subjected to statistical analysis.

Results: Groups were comparable to each other with respect to age, weight, gender, ASA status. Significant difference was found in HR, SBP, DBP between Group A and Group B at 1 minute and 2 minute after coinduction. MAP shows statistically highly significant (p < 0.001) results after 1minute and 2 minute of coinduction. Total dose of propofol required and mean BIS value shows highly significant results when compared between groups.

Conclusion: In conclusion, our study identified that overall dosage of propofol was significantly lower when modest doses of propofol and ketamine were given beforehand than when a placebo was used. When used as an induction agent, ketamine offers better haemodynamic stability.
LIMITATIONS OF PET SCAN IN THE DETECTION OF DISTAL METASTASES OF BRONCHOPULMONARY CANCER
Authors: Abdelhalim Boucaid , Anis Rafik , Abderrahman Ismail Rhorfi
Published: December 2024

Introduction: Positron Emission Tomography (PET) scanning has become essential in staging bronchopulmonary cancer, offering superior accuracy in detecting both mediastinal lymph node involvement and distant metastases. However, despite its advantages, PET scanning has notable limitations in detecting distal metastases.

Objective: To highlight the limitations of PET scanning in detecting distal metastases of bronchopulmonary cancer, particularly those located outside the standard acquisition field, through the presentation of two clinical cases.

Methods: We present two cases of bronchopulmonary cancer where PET scanning failed to detect distal bone metastases. The first case involves a tibial metastasis in a patient with squamous cell carcinoma, while the second case presents a humeral metastasis in a patient with small cell carcinoma.

Results: In both cases, PET scanning, which typically covers only from the base of the skull to the upper third of the thighs, missed the distal bone metastases that were later detected through other imaging modalities and confirmed by biopsy or additional testing. These metastases were located outside the standard PET acquisition field.

Conclusion: While PET scanning remains a cornerstone in bronchopulmonary cancer staging, practitioners must be aware of its limitations, thorough clinical examination and patient history remain essential components in the detection of distal metastases.
Mujeres, discursos y arqueología. No hablamos de anécdotas sino de realidades
Authors: Alarcon Garcia Eva , Rivera-Hernández Aurora
Published: December 2024

¿Cuánto hemos cambiado?, pregunta inofensiva en apariencia. El objetivo principal de este trabajo es analizar la presencia y ausencias de las mujeres en los discursos arqueológicos desde una perspectiva feminista. Para ello partimos de la premisa de que el uso de palabras e imágenes en la reconstrucción de nuestro pasado no es inocente ni inocuo sino premeditado y deliberado. La Arqueología de género y feminista lleva décadas denunciando la pervivencia de estereotipos, procesos de cancelación femenina y el mantenimiento de un sistema eurocéntrico y patriarcal en los procesos de construcción del conocimiento.
INVESTIGATION OF PSYCHOSOCIAL AND FUNCTIONAL DYNAMICS IN INDIVIDUALS WITH CHRONIC LOW BACK PAIN
Authors: Yerlikaya Tuba , Yazıcı Alikemal , Öniz Adile
Published: December 2024

Purpose: The aim of this study was to compare the functional status, psychological status, quality of life and disability levels of individuals with chronic low back pain (LBP) of different origins with healthy individuals.
Methods: A total of 141 individuals, including healthy, nonspecific, non-radiculopathy and radiculopathy groups, participated in the study. Measurements included, the International Physical Activity Questionnaire, physical endurance tests, Visual Analogue Scale, Roland Morris Disability Questionnaire, Trait Anxiety Inventory, Fear Avoidance Beliefs questionnaire and Nottingham Health Profile.
Results: Psychological status, disability level and quality of life scores except anxiety level in individuals with chronic LBP differed significantly in the lowest nonspecific group and the highest in the radiculopathy group (p
Application of fertigation using biotreated agro-industrial wastewater (with Bacillus paramycoides MT477810) on the growth of two vegetables Capsicum annuum (var. Astra) and Lycopersicon esculentum (var. Kristina)
Authors: Afzal Aqsa , Mirza Safdar Ali , Rashid Aneeba , Aslam Tahira , Campos Luiza C.
Published: December 2024

This research explored the use of the fertigation technique with treated agro-industrial wastewater to enhance the growth of Capsicum annuum (var. Astra) and Lycopersicon esculentum (var. Kristina). The wastewater, collected from Bajwa Agro Industries in Lahore, was biotreated using the bacterial strain Bacillus paramycoides MT477810, with a 10% inoculum incubated at 37 °C for 48 h. The bacterial strain achieved an 87% decolorization of the wastewater. Physicochemical analysis before and after biotreatment showed reductions in pH (60%), EC (22%), salinity (16%), turbidity (48%), COD (40%), BOD (73%), TDS (62%), and TSS (25%). The two vegetable varieties were fertigated with both biotreated and untreated wastewater to assess their effects on seed germination and plant growth. Results indicated a significant reduction in phytotoxicity (over 50%) in plants grown with biotreated wastewater. Additionally, plants irrigated with biotreated wastewater showed a 9–30% increase in fresh and dry weights compared to those irrigated with untreated wastewater. Nutritional analysis revealed that crops irrigated with treated wastewater had 12–48% higher nutrient content. These findings emphasize the effectiveness of biological wastewater treatment and fertigation in reducing pollutants and enhancing nutrient availability for vegetable crops.
Water balance and hydropluviometric variability of dams in Eastern Algeria
Authors: Boutouatou Farah , Mebarki Azeddine , Laignel Benoit , Nouaceur Zeineddinne
Published: December 2024

Eastern Algeria, the wettest region of the country, has experienced a vast program of dam construction, distributed across basins marked by strong physio-climatic disparities. The hydrological functioning studied through the use of data from the regulation balance sheet for the period from September 1990 to August 2013, concerned a sample of 10 dams (capacity varying from 3 to 200 hm³) whose year of impoundment varies from 1939 to 1987. The results of the statistical and spectral analysis applied to two main terms of the water balance (inputs and rainfalls) indicate a strong relationship between the studied parameters, reflecting a net increase in dry years from September 1990 to August 2002, with a return of wet years from the year 2003, however, interrupted by other very dry years like that of 2007/2008. The outflows (outputs) of the dams reflect considerable water losses in the form of evaporation and also in the form of leaks on karstic sites. However, it is the flood phenomena that are at the origin of remarkable overflows and bottom outlets. In addition to these losses, there are significant variations in the regulated volume of dams, particularly in semi-arid zones and during periods of drought, particularly.
Nidificação de gavião-pato, Spizaetus melanoleucus Vieillot, 1816 (Aves, Accipitridae) no município de Itaiópolis, Santa Catarina, sul do Brasil
Authors: Meyer Douglas
Published: December 2024

Em outubro de 2020, foi encontrado um ninho de Spizaetus melanoleucus em uma árvore emergente, localizada em um vale circundado por morros íngremes em forma de cristas, na margem esquerda do Rio Itajaí do Norte, município de Itaiópolis, Santa Catarina. Realizaram-se 60 visitas ocasionais na área do ninho até fevereiro de 2024. Foram acompanhados três períodos reprodutivos, verificando-se a média de 273 dias para todo o ciclo e a inclusão de serpentes como item alimentar para a espécie. O sucesso reprodutivo da espécie indica a importância da preservação da área florestal da calha do Rio Itajaí do Norte para a preservação da espécie.
Avanço do javali Sus scrofa (Linnaeus, 1758) na região dos Campos das Vertentes, Minas Gerais, sudeste do Brasil
Authors: De Sousa Oliveira Glauco Cássio , Pereira de Gouvêa Taiguara , Magalhães de Souza Marcos
Published: December 2024

O javali Sus scrofa (Linnaeus, 1758) está entre as principais espécies introduzidas no Brasil, com potencial invasivo e ocorre em praticamente todo o mundo. Populações invasoras de S. scrofa causam importantes problemas ecológicos e econômicos, principalmente nos locais em que crescem sem controle. No Brasil, os javalis já são responsáveis por causar esses problemas em diferentes regiões, mas principalmente na região Sudeste. Registra-se aqui, por observação ocasional realizada em 2022 e relatos de caçador legalizado pelos órgãos ambientais responsáveis, o avanço de S. scrofa nos municípios de Carandaí, Lagoa Dourada, Resende Costa, Ritápolis e São Tiago, que são os primeiros na porção norte da região dos Campos das Vertentes, Minas Gerais.
Fauna apícola (Apidae, Hymenoptera) em Barra do Sul, Santa Catarina, Brasil
Authors: Allison L. Tietz  , Romana P. Apel  , Gabriel da R. Schroeder  , Denise M. D. S. Mouga
Published: December 2024

Visando conhecer a apifauna de um ambiente costeiro no norte de Santa Catarina, foi realizado um levantamento em duas localidades de Balneário Barra do Sul: Fazenda Yakult/UFSC e Lagoa da Cruz. Foram feitas coletas com rede entomológica, iscas aromáticas e pratos-armadilha, de outubro de 2022 a setembro de 2023. Foram amostradas 40 espécies de abelhas e 25 espécies de plantas, durante 144 horas de esforço amostral. As subfamílias de abelhas Apinae, Halictinae e Megachilidae foram as mais prevalentes. Em ambos os locais, o táxon mais amostrado foi Dialictus sp. Os táxons amostrados são de ocorrência comum para a região nordeste de Santa Catarina, exceto Megachile (Cressoniella) cf. e Sarocolletes cf. Três espécies de abelhas são cleptoparasitas: Mesonychium littoreum, Coelioxys (Glyptocoelioxys) sp. e Leiopodus lacertinus. Amostraram-se quatro espécies de Euglossini. A curva do coletor não se estabilizou. O método de amostragem que capturou mais riqueza de espécies foi rede entomológica, seguida por prato-armadilha e isca de cheiro. Quatro produtos para iscas odoríferas foram efetivos (vanilina, cinamato de metila, cineol e eugenol). A diversidade mostrou-se mediana a baixa. As duas comunidades se apresentaram equilibradas, num padrão interativo medianamente generalista e robusto, organizadas num modelo de algumas poucas espécies mais representativas no ambiente.
Microbiological Assessment and Evaluation of Virus Yield in Germ-free Chicken Eggs
Authors: Adeyemi Oluwapelumi , dos Santos Ariane G B , Sadeyen Jean-Rémy , Carter Toby , Murphy Martin , Caulfield Catherine , Moran Leonard , Adeyemi Modupeore , Iqbal Munir
Published: December 2024

Background

Increasing yield will have major implications for vaccine manufacturers. Internal bacterial contamination of specific pathogen-free (SPF) eggs results in batches of vaccines being rejected and may negatively impact vaccine yield.

Objective

The objectives of this study were to analyze Germ-Free (GF) eggs microbiologically and evaluate the yield of H1N1 when compared with SPF eggs from 2 different suppliers.

Methods

The contents of GF eggs were analyzed using three different methods (sterility test, total viable count, and bioluminescence). Eggs from each source were inoculated with H1N1 virus. Chick Embryo Fibroblast (CEF) cell cultures were generated from GF and SPF eggs from both suppliers and infected with H1N1. The supernatant was titrated for viral Haemagglutinin activity and virus infectivity while cellular RNA extracts were assayed for Interferon (α and β) gene expression by RT-qPCR using gene-specific primers.

Results

The analysis of GF eggs confirmed that the contents were sterile. The batch yield of GF eggs was ~1.2-fold and ~1.8-fold higher than SPF supplier 1 and SPF supplier 2 virus yields, respectively. Replication of H1N1 was 2-fold higher in CEF derived from GF eggs than CEF derived from SPF supplier 1 or SPF supplier 2. IFN-β antiviral response of GF-derived CEF cells was 2-fold lower than SPF supplier 1-derived and ~3-fold lower than SPF supplier 2-derived CEF cells.

Conclusion

The content of GF eggs was sterile. The yield of H1N1 was higher in GF eggs than in SPF eggs, and the higher yield was associated with a significant reduction in interferon Beta levels.
THE RELATIONSHIP BETWEEN AGE AND PUBLIC KNOWLEDGE OF RHEUMATIC DISEASE IN MALANG 2017
Authors: Thariq Diefa Muhammad , Aditya Perdana , Mayangsari Elly
Published: December 2024

Rheumatic disease is a type of illness that affects the human musculoskeletal system. Rheumatic diseases are often associated with advancing age. This categorizes rheumatic diseases as conditions more prevalent among the elderly. Symptoms include pain and can be accompanied by redness, swelling, and other manifestations. Knowledge about a disease can prevent and reduce the risk of its occurrence. Age is one of the factors that can influence the level of knowledge about a disease. This study aims to determine the relationship between age and public knowledge, as well as the influence of age on the improvement of public knowledge about rheumatic disease. The study employed an analytical observational approach with a cross-sectional design. Data were collected from pre-test and post-test questionnaires distributed during a public seminar on rheumatic disease at the Faculty of Medicine, Brawijaya University, on October 8, 2017. The results indicated that the highest level of rheumatic disease knowledge was in the age range of 25-54 years. Moreover, the highest increase in knowledge was observed in the age range of <25-34 years. Spearman rank correlation analysis revealed no significant relationship between age and the increase in knowledge about rheumatic disease. However, the Wilcoxon test results indicated that the age range of 55->65 years exhibited a significant difference between pre-test and post-test scores. For future research, questionnaire validation before assessing knowledge levels is recommended.
Explaining REIT returns in emerging economies: A Fama-French approach with foreign investment and political stability
Authors:   College of Business, Effat University, Jeddah, Saudi Arabia, Baghlaf Naif , Shaheen Rozina ,   College of Business, Effat University, Jeddah, Saudi Arabia, Daou Lindos E. ,   College of Business, Effat University, Jeddah, Saudi Arabia
Published: December 2024

This study examines the applicability of the Fama-French 3-factor model to Real Estate Investment Trusts (REITs) in emerging economies using monthly data from January 2016 to December 2023 for 23 REITs across five emerging markets. A Generalized Method of Moments (GMM) (system) approach assesses the impact of 12 explanatory variables, including traditional factors like market, value, size, and momentum premiums, as well as emerging market-specific factors such as the Morgan Stanley Capital International (MSCI) Emerging Markets Currency Index and Bloomberg Commodity Ex-Agriculture Index. Control variables like political stability, foreign direct investment, and portfolio investment are also included. The results show that value premium, foreign direct investment, portfolio investment, and commodity prices positively influence REIT excess returns, while momentum premium and political instability negatively affect them. These findings highlight the combined importance of traditional and emerging market-specific factors, emphasizing the critical role of stable political conditions for REIT performance. This research contributes valuable insights for investors and policymakers in understanding REIT dynamics in emerging markets.
Prevention and Health Promotion Interventions for Young People in the Context of Digital Well-Being: Rapid Systematic Review (Preprint)
Authors: Colder Carras Michelle , Aljuboori Dahlia , Shi Jing , Date Mayank , Karkoub Fatima , García Ortiz Karla , Abreha Fasika Molla , Thrul Johannes
Published: December 2024

BACKGROUND

Increasing digital technology and media use among young people has raised concerns about problematic use and negative consequences. The formal recognition of a technology addiction (eg, gaming disorder) requires an understanding of the landscape of interventions designed to prevent this disorder and related technology addictions.

OBJECTIVE

We conducted a rapid systematic review to investigate the current evidence on approaches to prevent problematic technology use and promote digital well-being, defined as the healthy use of digital media and technology and the absence of problems resulting from excessive use.

METHODS

We used a pragmatic and rapid approach to systematically review and synthesize recent literature with a focus on contextual factors that can aid in understanding translatability, making trade-offs appropriate for rapid reviews per the Cochrane Collaboration guidelines. We searched multiple databases, including gray literature, for primary studies and systematic reviews of prevention interventions targeting children, adolescents, and youth. We extracted data on study characteristics, quality, and translatability and synthesized evidence through narrative description and vote counting of controlled trials. Data are openly available on our Open Science Framework website.

RESULTS

We found 6416 citations, of which 41 (0.64%) were eligible for inclusion (6 reviews and 35 primary studies of 33 interventions). Most interventions (26/33, 79%) combined intervention approaches and included an education component. Synthesis through vote counting showed benefits for all forms of digital well-being. Both included meta-analyses reported small positive effects on reductions of screen time. However, study reporting was overall lacking, impairing the ability to draw conclusions.

CONCLUSIONS

As digital technology use increases, interventions to prevent problematic technology use and promote digital well-being continue to proliferate. Understanding context factors that influence healthy technology use and understanding the limitations of the current evidence are vital for informing future research. This review demonstrates positive findings for the effectiveness of prevention interventions and describes factors that may contribute to translation and implementation. Future research would benefit from following appropriate reporting guidelines, reporting both the benefits and harms of interventions, and including greater detail on factors informing translation.

CLINICALTRIAL

PROSPERO CRD42023444387; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=444387
Enabling precision medicine through open standards in pharmacogenetics: data model development and Delphi study (Preprint)
Authors: Sharma Videha , McDermott John , Keen Jessica , Koikkalainen Heidi , McNicoll Ian , Newman William
Published: December 2024

BACKGROUND

Pharmacogenetics, a subset of precision medicine, leverages genetic testing to improve the safety and efficacy of prescribed medicines. Despite compelling evidence supporting its clinical and economic impact, widespread implementation remains limited. An established barrier to implementation is the lack of interoperable health information technology solutions that integrate pharmacogenetic data into frontline clinical workflows, particularly for non-specialist clinicians. Open data standards, such as openEHR and Fast Healthcare Interoperability Resources (FHIR) could address this by creating standardised, vendor-neutral formats for pharmacogenetic test results and thus enable precision medicine at scale.

OBJECTIVE

This study aimed to develop and validate open data standards to represent pharmacogenetic data using openEHR and map these standards to HL7 FHIR to enable interoperability within healthcare systems.

METHODS

We developed a baseline openEHR data model by synthesizing existing literature, genomic sequencing technology outputs, and international FHIR specifications. Using openEHR’s Archetype Designer, an iterative design process was followed, informed by workshops with the Global Alliance for Genomics and Health (GA4GH). The model subsequently underwent two rounds of Delphi peer review involving 24 international experts across 10 countries providing a total of 30 reviews across both rounds. Mapping to HL7 FHIR was performed using both manual and automated approaches, including the FHIR-Connect tool.

RESULTS

A standardised pharmacogenetic data model was developed, delineating "test results" from therapeutic implications to streamline clinical decision support (CDS). The final model incorporated globally recognized terminologies (e.g., SNOMED CT, HGNC) and was endorsed by the international expert Delphi review group. Published on the openEHR Clinical Knowledge Manager platform, the model achieved consensus for real-world deployment. HL7 FHIR mapping demonstrated successful bidirectional compatibility, supporting potential integration with English National Health Service (NHS) systems. Both manual and automated mapping approaches proved feasible, with the latter enabling scalable and reusable data transformations.

CONCLUSIONS

The study established a robust framework for storing and exchanging pharmacogenetic test results, addressing key barriers to precision medicine implementation. By separating test results from therapeutic implications and leveraging openEHR and FHIR, the proposed standards ensure semantic harmonisation and interoperability. These findings lay the groundwork for scalable implementation of pharmacogenetics, supporting CDS integration into routine care. Future efforts should focus on refining genomic data models, enhancing policy frameworks, and promoting cross-disciplinary collaboration to advance precision medicine.

CLINICALTRIAL

Not applicable
In silico evaluation of ten monoclonal antibodies neutralization power of SARS-CoV-2 variants EG.5, BA.2.86 and JN.1 (Preprint)
Authors: Ashoor Dana
Published: December 2024

BACKGROUND

The current globally dominant SARS-CoV-2 variants are showing immune escape and reduced susceptibility to antiviral drugs. Therefore, agencies responsible for drug evaluation and regulation such as the FDA and EMA are revising their emergency authorization use of several COVID-19 neutralizing antibodies. These NAbs proved to be unlikely effective against new variants especially Omicron descendants and several pharmaceutical companies are pursuing the development of more potent neutralizing antibodies.

OBJECTIVE

The aim of this study is to evaluate the SARS-CoV-2 antibodies neutralization power and to assess the effectiveness of the available SARS-CoV-2 neutralizing antibodies on the newly emerged variants Eris, Pirola and JN.1.

METHODS

Previously developed In Silico method w to assess 10 anti-SARS-CoV-2 antibodies propensity to neutralize the new Omicron’s subvariants EG.5, BA.2.86 and JN.1, based on comparative binding affinity of 3D generated models and previous experimental and clinical observations. Nine of these NAbs were once granted emergency use authorization, and one is currently under clinical investigation.

RESULTS

Our results showed that for EG.5 there was either a decrease or no change of the binding energy with 9 antibodies and a significant increase with one antibody. For Pirola (BA.2.86) and JN.1, a significant increase was observed with two antibodies. This data indicates that the new SARS-CoV-2 variant escapes neutralization of most of the available therapeutic NAbs. However, the two NAbs that showed an increase in the binding affinity with the new variants may be considered for therapeutic use. The In silico predictions of the clinical usefulness of 10 anti SARS-CoV-2 antibodies are consistent with published clinical and experimental data.

CONCLUSIONS

Computational predictions of the neutralizing potential of existing anti SARS-Cov-2 antibodies is very useful in defining NAbs or NAbs combination that could be effective for the treatment countermeasure of the new Omicron’s subvariants Eris (EG.5), Pirola (BA.2.86) and JN.1 or potential novel variants.
Experiences of using SuMMiT-D, a digital brief messaging intervention to support oral medication adherence for people living with type 2 diabetes in England: a qualitative process evaluation. (Preprint)
Authors: Newhouse Nikki , Bartlett Yvonne Kiera , Simao Sara Correia , Miles Lisa , Cholerton Rachel , Kenning Cassandra , Locock Louise , Williams Veronika , French David P , Rea Rustam , Farmer Andrew
Published: December 2024

BACKGROUND

Poor adherence to oral medications for type 2 diabetes can increase the risk of health complications. Digital interventions can affect people’s experiences of self-managing a chronic condition and text messages may provide an effective delivery method for an intervention. The SuMMiT-D (Support Through Mobile Messaging and Digital Health Technology for Diabetes) intervention uses evidence-based SMS messages to support people with type 2 diabetes with regular and consistent use of diabetes medication.

OBJECTIVE

This process analysis, conducted alongside a randomised controlled trial of SuMMiT-D aimed to explore i) the contextual factors which may interact with the SuMMiT-D intervention and ii) the self-reported mechanisms by which change in behaviour or attitude might occur.

METHODS

A nested qualitative process study was conducted within Primary Care in England, UK. Forty-three trial participants diagnosed with type 2 diabetes, who were assigned to receive the SuMMiT-D intervention and taking oral glucose-lowering treatment, blood pressure–lowering treatment, or lipid-lowering treatment either alone or in combination, and who had access to a mobile phone, took part in semi-structured telephone interviews. Data were analysed using inductive thematic analysis.

RESULTS

Two overarching themes were developed, exploring relevant contextual factors and potential mechanisms of change. The system exerted a range of holistic benefits and supported the cognitions, beliefs and behaviours necessary for longitudinal self-management. The perceived value of the messages was fluid and linked to contextual need. Appraisal of the system was influenced by existing routines, lifestyle disruption, people’s understanding of type 2 diabetes, relationships with other people, and subjective attitudes to living with type 2 diabetes in contemporary society.

CONCLUSIONS

This work demonstrates the value of engaging people longitudinally in thinking about their general health, the importance of interrogating context and the holistic benefit of health messaging. Many people perceived wide-ranging and unexpected benefits from using the intervention over time, challenging assumptions about who might be expected to appraise the system more positively, and who should be offered access to it.
Digital Safety Plan Activation Reduces Subsequent Emergency Departments Visits Following an Initial Suicide Attempt (Preprint)
Authors: Schmidt Carlos , Barrigón María Luisa , Elices Matilde , Porras-Segovia Alejandro , de Granda-Beltrán Ana María , Artés-Rodríguez Antonio , Coarte Philippe , Pérez-Sola Víctor , Baca-García Enrique
Published: December 2024

BACKGROUND

Suicide is a significant global public health concern. Individuals with suicidal behaviors often seek help in emergency departments (ED), making mental health providers critical in suicide prevention. Brief interventions, such as safety planning, are essential in these settings. However, there is a limited understanding of how mobile digital applications of safety planning could enhance the effectiveness of in-person care provided by mental health professionals while simultaneously reducing their workload.

OBJECTIVE

This study evaluated the effectiveness of a digital safety plan, delivered through the MEmind app, in reducing ED visits for suicide-related concerns.

METHODS

A one-year follow-up was conducted on individuals who presented to the ED after a suicidal crisis (n = 78). Participants were provided with a digital safety plan on their mobile devices and instructed to activate it during future suicidal crises.

RESULTS

Participants who activated the digital safety plan showed a 50% lower likelihood of returning to ED.

CONCLUSIONS

These findings suggest that digital safety planning may be a scalable and accessible intervention with the potential to significantly contribute to suicide prevention efforts.
Study of Adhesive Bonded Joints between Metallic Plates and Composite Laminates
Authors: P Prasad
Published: December 2024

Many researchers studied influences of various parameters on the failure behavior on the composites. One of the
challenges in the analysis and design of bonded joints is the valuation of the stress and strain fields at the adhesive layer and
adherents. The present investigation deals with the analysis of adhesively bonded dissimilar material single lap joints (SLJ)
between mild steel and unidirectional carbon fibres reinforced polymer (CFRP) laminates. The primary objective of this study is
to investigate the effects of various parameters, such as bonding strength, overlap length, adherend thickness, and adhesive
thickness, on the failure load and failure mode of joints with dissimilar materials. Failure process, mode and strength of
unidirectional composite to mild steel single lap adhesive bonded joints were investigated numerically by using finite element
methods. Numerical methods based on finite element models can be very useful in describing the stress and strain responses for
each load step. The SLJ specimens are done nonlinear analysis and predict the force -displacement and force- strains curves and
conclusions regarding joint stiffness and strength are obtained for different cases of SLJ
BOBBY SAPUTRA AND HIS SATIRE IN THE DIGITAL REALM: A VISUAL-VERBAL VIDEO ANALYSIS
Authors: Rahmawati Chatarina Tri
Published: December 2024

Satire is a linguistic device that can be used as a way to ridicule or critique certain people or group of community. There had been numerous studies related of the use of satire in the world of politics, yet almost none of them addressed the nonpolitical aspect. The use of satire extends beyond political news, rather it has been starting to appear on certain social media posts on social media, including platforms like TikTok. This study sought on the way satire was utilized in some TikTok videos made by @supercoolben10 that were mostly talking about the life of upper class society. To add the novelty of this qualitative study, VVVA (Visual-Verbal Video Analysis) framework was utilized in analyzing the video. After a number of seven videos underwent the six processes of VVVA, it was found that both visual and verbal components take parts in constructing a good satire that could be used as a social critique. The findings in this study were presented into four sub-topics: 1) Satire as Social Critique on Economic Inequality, 2) The Role of Visual and Verbal Elements in Satire, 3) Effectiveness of VVVA for Analyzing Satire on TikTok, and 4) Broader Implications for Satire and Social Critique on Digital Platforms.
ANÁLISE DE FORÇAS DE MOVIMENTAÇÃO E CARACTERÍSTICAS FÍSICO-QUÍMICAS EM ALINHADORES ORTODÔNTICOS: AVANÇOS TECNOLÓGICOS E CONSIDERAÇÕES CRÍTICAS
Authors: Holderbaum da Costa e Silva Gustavo , Beatrici Anderson , Takamori Esther Rieko , Granjeiro José Mauro
Published: December 2024

O avanço tecnológico revolucionou a prática odontológica, com os alinhadores ortodônticos emergindo como uma escolha altamente popular entre pacientes que buscam tratamentos estéticos e confortáveis. No entanto, apesar de sua crescente demanda, permanecem questões cruciais relacionadas à eficácia e análise dimensional desses dispositivos. Este artigo oferece uma análise abrangente das características químicas, físicas e mecânicas dos alinhadores ortodônticos, iluminando a influência vital do processo de termoformação e da espessura nas propriedades desses materiais. Compreender profundamente essas características é essencial para aprimorar a eficácia e a durabilidade dos alinhadores ortodônticos, contribuindo, assim, para o sucesso e a evolução dos tratamentos ortodônticos modernos. Neste estudo, exploraremos: 1) as propriedades químicas dos materiais e como elas afetam a biocompatibilidade e a resistência à degradação; 2) as características físicas, incluindo textura de superfície, transparência e sua influência na adaptação bucal e no conforto do paciente; 3) as propriedades mecânicas, como flexibilidade e rigidez, e como essas características afetam a distribuição de forças de movimentação dentária; 4) a influência do processo de termoformação na precisão e reprodutibilidade dos alinhadores, bem como sua relação com a qualidade do tratamento; 5) a análise crítica da espessura dos alinhadores e seu papel na capacidade de aplicar forças adequadas para a movimentação dentária. Ao abordar esses aspectos, este artigo visa oferecer uma visão holística das complexidades envolvidas na fabricação e uso de alinhadores ortodônticos. Esperamos que esta revisão contribua para uma compreensão mais profunda desses dispositivos e promova avanços significativos na ortodontia, beneficiando tanto os profissionais quanto os pacientes.
Palavras-chave: Alinhadores Estéticos; Torção Mecânica, Ciência dos Materiais.
PLATAFORMA CONE MORSE, A MELHOR OPÇÃO PARA A BIOMECÂNICA E ESTÉTICA EM PRÓTESES SOBRE IMPLANTE: UMA REVISÃO DE LITERATURA
Authors: Oliveira da Conceição Amanda
Published: December 2024

A escolha da plataforma protética em implantodontia é fundamental para garantir o sucesso a longo prazo dos procedimentos. Todos os tipos de conexão protética apresentam vantagens e desvantagens, cabendo ao cirurgião-dentista optar pelo o que melhor se adepta ao seu caso. Uma revisão de literatura foi realizada, abrangendo estudos relevantes que compararam essas duas plataformas protéticas em termos de biomecânica e estética. Foram analisadas revisões de literatura e estudos in vitro, sob as palavras-chave “cone morse”, “biomechanics”, “abuptment”. As pesquisas foram feitas nas bases de dados Scielo e PubMed, e os artigos escolhidos deveriam abordar a estabilidade das conexões, a preservação óssea e a estética peri-implantar. Os resultados da revisão demonstram que a plataforma Cone Morse oferece uma interface mais estável, reduz o afrouxamento de parafusos e minimiza a infiltração bacteriana. Com isso, o Cone Morse contribui para a preservação das estruturas ósseas e gengivais ao redor do implante, tornando-se uma escolha valiosa, especialmente em procedimentos de reabilitação estética.
Palavras- chave: Cone Morse. Biomecânica. Estética. Microespaço.
CIRURGIA PARENDODÔNTICA: REVISÃO DE LITERATURA
Authors: Martins Gabriel , Fernandes Alexandre Moreira , Duarte Alice Menezes , Cristo Artur Tavares , De Castro Isabela Soares , Libânio Lívia Fulgêncio
Published: December 2024

O tratamento endodôntico envolve procedimentos como abertura coronária, modelagem, limpeza, desinfecção e selamento tridimensional. Apesar de apresentar um índice de insucesso de cerca de 4%, retratamentos podem ser realizados por cirurgiões-dentistas habilitados. Quando o retratamento não é indicado, a cirurgia parendodôntica, que inclui curetagem, apicectomia e retro obturação do sistema de canais, surge como uma alternativa eficaz para manter o dente em função e estética na cavidade bucal, antes de considerar a extração. O presente trabalho busca revisar a literatura respeito da cirurgia parendodôntica. Os trabalhos foram selecionados nas plataformas Scielo, PubMed, Google Acadêmico e BVS, publicados nos últimos 5 anos em português e inglês. Pôde-se concluir que a cirurgia parendodôntica é uma alternativa efetiva em casos de insucesso do tratamento endodôntico, devendo ser considerada e indicada de maneira apropriada.