bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of a Learning Module Using Constructive Alignment Theory in Project Managerial Course
Authors: Indriati Lisa , Anggrianto Christian
Published: February 2022

The research intended to develop an ideal learning module using constructive alignment theory on Project Managerial course. It seemed difficult to draw firm conclusions about constructivism due to the various interpretations both pedagogically and epistemically. The mixed-method was used to survey 56 students participating in the Project Managerial course. Moreover, qualitative methods were implemented for deeper analysis. The methods provided an overview of the students’ level of understanding of the material, what they can do at the end of the lesson, as well as learning activities that can help students be actively involved in class. It was also to find out whether students have achieved the expected outcomes. The results prove that students’ understanding of the Project Managerial course is good, with an average score of 59,80 before the test and 85,88 after the test (n = 56). Students’ feedback shows that group assignment remains lacking of students’ participation with an average value of 3,4. In every relationship between the client and the designer, there are more or less the same systematic phases so that the results can be consistent. Different designers may have different terms. The research provides a big picture of the ideal design project management pattern. Whatever term is used later, of course, every successful design project must be managed properly and consistently.
Is chapter IX of the Chronicle of the Priest of Dioclea of Moravian-Pannonian origin?
Authors:   Comenius University in Bratislava, Homza Martin
Published: February 2022

The article offers a new interpretation of the account of the king Svetoplek (Svatopluk) from chapter IX of the Chronicle of the Priest of Dioclea. According to the author, chapter IX is based on an ancient work about king Svatopluk I of Moravia, which was written between 885 and 894 in connection with the coronation of Svatopluk as a «king of the Slavs» (rex Sclavorum). As the author of the article proves, the events described in this ancient source (the twelve-day diet and the subsequent coronation of Svatopluk) took place not on the territory of Duklja, but on the territory of Pannonia, in the places where Roman settlements were located in the Szekesfehervar region or in the Veszprem region. In the second half of the 11th century, during the reign of the Dioclean rulers Mihailo Vojislavljević and his son Constantine Bodin, the text of this ancient source was revised in the process of compiling the Vojislavljević dynastic history «Gesta regum Sclavorum». At the same time, the story about King Svatopluk was used by Benedictine monks from the circle of Roman popes to legitimize the new status of the kings of Dioclea as «kings of the Slavs». The author shows that during the period of the struggle between the papacy and the empire at the end of the 11th – beginning of the 12th century the idea of ​​reviving the «kingdom of the Slavs» (regnum Sclavorum), devoted to Rome, enjoyed great support from the Roman throne. In this context, the image of Svatopluk as the first «king of the Slavs» recognized by Rome was actualized and became the basis for the formation of the church and political ideology of the Dioclean dynasty of Vojislavljević.
Herman Kazansky’s demarche against the «Oprichnina»: Historical realities and interpretations
Authors:   «Vzmach Educational Complex», Belov Nikita Vasilyevich
Published: February 2022

This article discusses the debatable question about the demarche of Herman Kazansky against the Oprichnina. The author analyzes this event and suggests that Herman supported Metropolitan Philip (Kolychev) in his speech against the expansion of the Oprichnina policy in 1567. Over time, Herman’s act began to become overgrown with ecclesiastical legends. In the Life of the saint, written in the 1660s at the behest of the Kazan Metropolitan Lawrence II, it was first said, that Herman defended Metropolitan Philip during the Council trial in the fall of 1568. After the inspection of Herman’s relics in 1889, a version of his death at the hands of the oprichniks appears in the church press. Thus, by the early 20th century, the eparchial government of Kazan presented Herman as a martyr who stood up for the disgraced Metropolitan Philip and was executed by order of Ivan the Terrible. Sources from the 16th century completely refutes the first part of this image, the act of opening the relics of Herman of Kazan in May 1923 — the second one.
One more time about tactics and weaponry
Authors:   University of Bialystok, Sowa Jan Jerzy
Published: February 2022

Mark W. Shearwood’s study is devoted to the use of plug bayonets in the English army in the second half of the 17th and early 18th centuries. The author has shown that the plug bayonet was a more universal weapon than the socket bayonet. He rightly emphasizes in the conclusions of his work that when studying the history of military weaponry, especially in the pre-industrial period, specific dates for weaponry changes in particular armies and units cannot be provided. The conclusion is right that the plug bayonet was not supposed to replace pikes completely as was originally assumed by the then commanders; initially, the bayonets were used to equip troops of dragoons and grenadiers, i. e. the soldiers that did not have pikes on their equipment before. This study on the rearmament of individual armies is of interest to historians dealing with Central and Eastern Europe. It is connected with the important question of the continuity in the field of weapons between the West and Central and Eastern Europe at the turn of the 17th and 18th centuries. It seems that on the basis of the preserved source base it is not possible to jump at any conclusions concerning the use of the plug bayonet going further than those presented by the author.
The Courland campaigns 1705–1706
Authors:   Nicolaus Copernicus Public Provincial Library in Torun, Balcerek Mariusz Adrian
Published: February 2022

This article aims to present a critical book by Vladimir Sergeyevich Velikanov, and Sergey Leonidovich Mekhnev caught our attention to the Courland campaign of 1705–1706 and the battle of Gemauerthof (lat. Mūrmuiža). The authors of the reviewed work described a fragment of the Great Northern War, which was unknown until now.
Deciphering the projected changes in CMIP-6 based precipitation simulations over the Krishna River Basin
Authors: Anil Suram , Anand Raj P.
Published: February 2022

The impact of climate change on the Krishna River Basin (KRB) is significant due to the semi-arid nature of the basin. Herein, 21 global climate models (GCMs) of Coupled Model Intercomparison Project Phase 6 (CMIP6) were examined to simulate the historical monthly precipitation over the 1951–2014 period in the KRB. The symmetrical uncertainty (SU) method and the multi-criteria decision method (MCDM) were employed to select the suitable GCMs for projecting possible changes in precipitation over the KRB. The biases in the climate projections were removed by using the empirical quantile mapping method. The reliability ensemble averaging (REA) method was used to generate the multi-model ensemble (MME) mean of projections and to analyse the spatio-temporal changes of precipitation under different shared socioeconomic pathways (SSPs). BCC-CSM2-MR, IPSL-CM6A-LR, MIROC6, INM-CM5-0, and MPI-ESM1-2-HR were found to be the most suitable GCMs for the KRB. The MME mean of the chosen GCMs showed significant changes in precipitation projection that occurs for a far future period (2071–2100) over the KRB. The projection changes of precipitation range from −36.72 to 83.05% and −37.68 to 95.75% for the annual and monsoon periods, respectively, for various SSPs. Monsoon climate projections show higher changes compared with the annual climate projections, which reveals that precipitation concentration is more during the monsoon period over the KRB.
Response of regional agricultural water use to the change of climate and plantation structure in the typical agricultural region of China
Authors: Wang Kaixuan , Sun ShiKun , Li Yingjie , Hu Xinyu , Qi Xinyu , Wang Jiahui , Li Chong , Gao Fei
Published: February 2022

Climate is one of the main factors affecting agricultural water use. The variation of different climate factors will have a great impact on the balance of water supply, which will significantly aggravate the water-related threats to the sustainability of agricultural production. As a typical agricultural area of China, the Huang-Huai-Hai region is one of the major grain-producing areas. In order to evaluate the response of future agricultural water use to future uncertain changeable factors, this study assessed future agricultural water use with the coupling effect of climate change, irrigation efficiency and plantation structure change. The results showed that the temperature and precipitation both increased to different degrees under the two greenhouse gas emission and radiation forcing scenarios, which have great impacts on the crop water requirement (ETc) of main crops. Under RCP (Representative Concentration Pathways) 8.5, a 10% increase in the irrigation water utilization coefficient will reduce the regional irrigation water requirement by about 13 Gm3, and the adjustment of plantation structure will reduce the irrigation water consumption by about 11 Gm3. The quantitative analysis suggests that the improvement of the irrigation efficiency and the expansion of water-saving crop plantation areas in the future will moderate the adverse impact of climate change on agricultural water use. This study provides a reference for the management of agricultural water and the rational distribution of water resources under the future climate change.
Molecular Signaling Pathways as Potential Therapeutic Targets in Osteosarcoma
Authors: Dana Parisa Maleki , Sadoughi Fatemeh , Asemi Zatollah , Yousefi Bahman
Published: February 2022

Among primary bone malignancies, osteosarcoma (OS) is the most common
form causing morbidity and mortality in both adults and children. The interesting point
about this malignancy is that nearly 10-20% of its newly diagnosed cases have developed
metastasis. This adds up to the fact that the survival rate of both metastatic and non-metastatic
patients of osteosarcoma has not changed in the past 30 years; therefore, it has
been suggested that we need to revise our therapeutic options for OS. In recent years, diverse
signaling pathways have drawn the attention of the scientific community since they
can be great candidates for treating complicated diseases, such as cancer. In this review,
we have tried to explain the pathophysiology of osteosarcoma with the help of different
signaling pathways taking part in its initiation/progression and explore how this pathway
can be targeted for providing more efficient methods.
Chemically Modified Chitosan Supports for Phosphine-free Pd-catalyzed Crosscoupling Reaction of Arylboronic Acids with Acid Chlorides
Authors: Kong Hyoung-Jun , Bang Do-Won , Kim Minji , Park Soo-Youl , Kim Seung-Hoi
Published: February 2022

Backgroung:

Phosphine-free Pd-catalytic platforms, i) combination with chitosan- Schiff base (CS-Py/Pd), ii) immobilized on chitosan-Schiff base (CS-Py@Pd), and iii) anchored to modified carbon nanotube support (CNT@CS-Py@Pd),

Methods:

They were evaluated regarding a novel pathway for the cross-coupling reaction of arylboronic acids with acid chlorides.

Results:

The CS-Py@Pd platform had the highest catalytic efficiency of the three platforms, yielding moderate to excellent yields of diaryl ketones.

Conclusion:

The catalytic activity of the Pd-catalyst was highly dependent upon the manufacturing process and type of support.
Organoboronic Acids: A Chance for Improving Photochemistry
Authors: Kliś Tomasz
Published: February 2022

Photoredox catalysis as a powerful strategy for the activation of small molecules
requires the use of reactants which are suitable to undergo single-electron transfer with the
formation of radicals. In this perspective, we highlight the unique ability of organoboronic acid
derivatives to form radicals under photoredox catalysis conditions with particular emphasis
placed on the methods of activation of B-C bonds. Key to facilitate the activation relies on use
of easily oxidizable organoboronate complexes: organotrifluoroborates, alkoxyorganoboronates
or nitrogen-containing Lewis base adducts. The low reduction potentials of these compounds
allows facile single-electron oxidation to generate non-stabilized alkyl radicals, including
primary radicals, under mild conditions. The use of molecular oxygen is also a common
way to activate boronic acids in photocatalytic reactions. The role of the oxygen relies on addition
of the oxygen anion-radical formed in the photocatalytic cycle to the boron center affording the easily oxidizable
boronate adduct. Amongst the variety of activation methods, the protocols avoiding the use of external Lewis
base are especially valuable. This has been demonstrated in visible-light-mediated alkenylation of alkylboronic
acids using alkenylsulfones as coupling partners. The radical species resulting from alkylboronic acid derivatives
could be utilized in the formation of C–X or C–C bonds including enantioselective photoreactions. The application
of boronic acids in the visible light-driven installation of side chains at dehydroalanine residues in proteins shows
the increasing role of these compounds in future syntheses of complex natural products.
Repurposing Ayush-64 for COVID-19: A Computational Study Based on
Network Pharmacology and Molecular Docking
Authors: K.C. Mahija , K.A. Abdul Nazeer
Published: February 2022

Background:

As COVID-19 pandemic continues to affect people’s lives, the government
of India gave emergency use approval to the ayurvedic antimalarial drug Ayush-64 in April
2021 to treat asymptomatic COVID-19 positive and mild COVID-19 positive patients.

Objective:

This study aims to explore the therapeutic potential of Ayush-64 to treat COVID-19 and
provide a new approach for repurposing Ayurvedic drugs.

Methods:

The bioactives present in Ayush-64 were found along with their targets, and a plantbioactive-
target network was created. A protein-protein interaction network of the common targets
of Ayush-64 and COVID-19 was constructed and analyzed to find the key targets of Ayush-64 associated
with the disease. Gene ontology and pathway enrichment analysis were performed to find
COVID-19 related biological processes and pathways involved by the key targets. The key bioactives
were docked with SARS-CoV-2 main protease 3CL, native Human Angiotensin-converting
Enzyme ACE2, Spike protein S1, and RNA-dependent RNA polymerase RdRp.

Results:

From the 336 targets for Ayush-64, we found 38 key targets. Functional enrichment analysis
of the key targets resulted in 121 gene ontology terms and 38 pathways. When molecular
docking was performed with four receptors, thirteen bioactives showed good binding affinity comparable
to that of the eight drugs presently used to treat COVID-19.

Conclusion:

Network pharmacological analysis and molecular docking study of Ayush-64 revealed
that it can be recommended to treat COVID-19. Further in vitro and in vivo studies are needed
to confirm the results. The study demonstrated a new approach for repurposing Ayurvedic drugs.
Vitamin K Supplementation in Chronic Kidney Disease Patients: Where is
the Evidence?
Authors: Roumeliotis Stefanos , Liakopoulos Vassilios , Schurgers Leon J.
Published: February 2022

Vascular calcification (VC) is highly prevalent in Chronic Kidney Disease (CKD) patients,
progresses gradually with deterioration of kidney function and is a strong, independent predictor of
cardiovascular (CV) mortality. Matrix Gla Protein (MGP), the most potent inhibitor of VC, requires
vitamin K as a co-factor to become biologically active. Accumulating epidemiological data have associated
vitamin K depletion with VC progression and CV outcomes. CKD patients are characterized by
poor vitamin K status and at the same time, pronounced CV calcification. In early and advanced CKD,
including end-stage kidney disease, exogenous supplementation of vitamin K (especially with menaquinone
7, its most bioavailable form) might decrease the inactive form of MGP (dephosphorylated, uncarboxylated
MGP) and probably retard the progression or even reverse VC. Here, we focus and discuss
the interventional human studies of vitamin K supplementation in CKD patients and suggest future directions
in this area of interest.
Collaborative Mining of Whole Genome Sequences for Intelligent HIV-1
Sub-Strain(s) Discovery
Authors: Ekpenyong Moses E. , Adegoke Anthony A. , Edoho Mercy E. , Inyang Udoinyang G. , Udo Ifiok J. , Ekaidem Itemobong S. , Osang Francis , Uto Nseobong P. , Geoffery Joseph I.
Published: February 2022

Background:

Effective global antiretroviral vaccines and therapeutic strategies depend
on the diversity, evolution, and epidemiology of their various strains as well as their transmission
and pathogenesis. Most viral disease-causing particles are clustered into a taxonomy of subtypes to
suggest pointers toward nucleotide-specific vaccines or therapeutic applications of clinical significance
sufficient for sequence-specific diagnosis and homologous viral studies. These are very useful
to formulate predictors to induce cross-resistance to some retroviral control drugs being used across
study areas.

Objective:

This research proposed a collaborative framework of hybridized (Machine Learning and
Natural Language Processing) techniques to discover hidden genome patterns and feature predictors
for HIV-1 genome sequences mining.

Method:

630 human HIV-1 genome sequences above 8500 bps were excavated from the National
Center for Biotechnology Information (NCBI) database (https://www.ncbi.nlm.nih.gov) for 21
countries across different continents, except for Antarctica. These sequences were transformed and
learned using a self-organizing map (SOM). To discriminate emerging/new sub-strain(s), the HIV-1
reference genome was included as part of the input isolates/samples during the training. After training
the SOM, component planes defining pattern clusters of the input datasets were generated for
cognitive knowledge mining and subsequent labeling of the datasets. Additional genome features,
including dinucleotide transmission recurrences, codon recurrences, and mutation recurrences, were
finally extracted from the raw genomes to construct output classification targets for supervised
learning.

Results:

SOM training explains the inherent pattern diversity of HIV-1 genomes as well as interand
intra-country transmissions in which mobility might play an active role, as corroborated by the
literature. Nine sub-strains were discovered after disassembling the SOM correlation hunting matrix
space attributed to disparate clusters. Cognitive knowledge mining separated similar pattern clusters
bounded by a certain degree of correlation range, as discovered by the SOM. Kruskal-Wallis ranksum
test and Wilcoxon rank-sum test showed statistically significant variations in dinucleotide, codon,
and mutation patterns.

Conclusion:

Results of the discovered sub-strains and response clusters visualizations corroborate
the existing literature, with significant haplotype variations. The proposed framework would assist
in the development of decision support systems for easy contact tracing, infectious disease surveillance,
and studying the progressive evolution of the reference HIV-1 genome.
Synthesis of Pyrimidine Hybrids Based on 4H-Pyran and 4H-Chromene
Privileged Structures
Authors: Zonouz Adeleh Moshtaghi , Ghaffari, Parisa , Pourreza Azita
Published: February 2022

A combinatorial library of pyrimidine hybrids based on 4H-chromene and 4H-pyran privileged
structures has been developed by reacting phenyl isothiocyanate with chromene derivatives 1a-j
and pyranopyrazoles 2a-f in refluxing dry pyridine, respectively. Thus, the target pyrimidine hybrids
3a-j and 4a-f were obtained in good yields with a simple reaction strategy.
Identification and Validation of Hydroxychavicol from Betel Leaf as a
Promising Breast Cancer Inhibitor: An In vitro and In silico Analysis
Authors: Langeswaran K. , Sangavi P. , Sangeetha R.
Published: February 2022

Aim:

This study aimed at identifying promising breast cancer inhibitors through in vitro and
in silico studies.

Background:

Piper betel. L. is a traditional herb used for varied ailments.

Objective:

The present study is designed to evaluate the anti-carcinogenic potency of HC against the
MCF-7 cell line by in vitro analysis. Further in silico examination was performed to detect and formulate
protein-ligand complex of HC using molecular docking technique.

Methods:

In vitro study was conducted using MTT assay and microscopic examinations to determine
the cell viability and morphological changes in MCF-7 cells. In silico, scrutiny was performed using
virtual screening, Docking, ADME, DFT analysis, MMGBSA, and molecular dynamic simulation to
evaluate hydroxychavicol stability.

Results:

HC showed an outstanding anti-cancer potential, with dose- and time-dependent patterns in
MTT assay and through the fluctuating organization of MCF-7 cells. In silico analysis showed that the
selected lead compound-complex exhibited good stability and was a highly potent inhibitor against the
target breast cancer protein.

Conclusion:

This study confirmed that HC might be an alternate potential inhibitor against breast cancer.
Nanocapsules: An Emerging Drug Delivery System
Authors: Purohit Deepika , Jalwal Pawan , Manchanda Deeksha , Saini Sapna , Verma Ravinder , Kaushik Deepak , Mittal Vineet , Kumar Manish , Bhattacharya Tanima , Rahman Md. Habibur , Dutt Rohit , Pandey Parijat
Published: February 2022

Background:

Controlled drug release and site-specific delivery of drugs make nanocapsules the most approbative drug delivery system for various kinds of drugs, bioactive, protein, and peptide compounds. Nanocapsules (NCs) are spherical shape microscopic shells consisting of a core (solid or liquid) in which the drug is positioned in a cavity enclosed by a distinctive polymeric membrane.

Objectives:

The main objective of the present study is to elaborate on various formulation techniques and methods of nanocapsules (NCs). The review also spotlights various biomedical applications as well as on the patents of NCs till date.

Methods:

The review was extracted from the searches performed using various search engines such as PubMed, Google Patents, Medline, and Google Scholars, etc. In order to emphasize the importance of NCs, some published patents of NCs have been also reported in the review.

Results:

NCs are tiny magical shells having incredible reproducibility. Various techniques can be used to formulate NCs. The pharmaceutical performance of the formulated NCs can be judged by evaluating their shape, size, entrapment efficiency, loading capacity, etc. using different analytical techniques. Their main applications are found in the field of agrochemicals, genetic manipulation, cosmetics, hygiene items, strategic distribution of drugs to tumors, nanocapsule bandages to combat infection, and radiotherapy.

Conclusion:

In the present review, our team made a deliberate effort to summarize the recent advances in the field of NCs and focus on new patents related to the implementation of NCs delivery systems in the area of some life-threatening disorders like diabetes, cancer, and cardiovascular diseases.
Theranostic Applications of Stimulus-Responsive Systems based on Fe2O3
Authors: Pourmadadi Mehrab , Ahmadi Mohammad Javad , Dinani Homayoon Soleimani , Ajalli Narges , Dorkoosh Farid
Published: February 2022

According to the interaction of nanoparticles with biological systems, enthusiasm for
nanotechnology in biomedical applications has been developed in the past decades. Fe2O3 nanoparticles,
as the most stable iron oxide, have special merits that make them useful widely for detecting
diseases, therapy, drug delivery, and monitoring the therapeutic process. This review presents the
fabrication methods of Fe2O3-based materials and their photocatalytic and magnetic properties.
Then, we highlight the application of Fe2O3-based nanoparticles in diagnosis and imaging, different
therapy methods, and finally, stimulus-responsive systems, such as pH-responsive, magneticresponsive,
redox-responsive, and enzyme-responsive, with an emphasis on cancer treatment. In
addition, the potential of Fe2O3 to combine diagnosis and therapy within a single particle called
theranostic agent will be discussed.
Clinical status of patients with coronary artery disease post COVID-19
Authors: Khidoyatova Mukhlisa Rakhmatillaevna , Kayumov Ulugbek Karimovich , Inoyatova Feruza Khidoyatovna , Fozilov Khurshid Gayratovich , Khamidullaeva Gulnoz Abdusattarovna , Eshpulatov Aziz Sagdullaevich
Published: February 2022

The main goal of our study was to identify the activity of cardiac dysfunction based on the analysis of the main cardiological methods of research, such as ECG, echocardiography, 24-hour ECG monitoring in conjunction with laboratory parameters in patients with coronary artery disease (CAD) who underwent mild and moderate COVID-19, without signs of residual effects of lung tissue damage (fibrotization). 52 patients with coronary artery disease were examined, which were divided into 2 groups depending on the past infection in history: 1 group without COVID-19 in history (n=26) (based on history and results of SARS-CoV-2 antibody titer), 2 a group with a history of COVID-19 (n=26), confirmed by relevant documents (tests), but without oxygen therapy and steroids, in order to avoid the influence of a serious illness and drug exposure. Conclusions: dynamic monitoring of hemostasis parameters after the hospital stage in patients with CAD should be carried out in order to prevent adverse cardiovascular outcomes, even with a history of moderate and mild coronavirus infection. One of the aspects of therapeutic rehabilitation in the post-COVID period in patients with IHD is the use of vitamin D preparations.
Trade sales promotion and distributors’ performance of fast-moving consumer goods (FMCGS)
Authors: Etuk Aniebiet , Anyadighibe Joseph A. , James Edim Eka , Egemba Peter Miracle
Published: February 2022

This study examined trade sales promotion and distributors’ performance of fast-moving consumer goods (FMCGs). It was carried out to establish the effects of trade allowance, dealers’ contest and rebate on distributors’ performance with special reference to fast-moving consumer goods. The study adopted survey research design. The sampling technique adopted was judgmental sampling. Primary data were obtained from 218 retailers and wholesalers of fast-moving consumer goods using a 5-point Likert scale questionnaire. The hypotheses developed for the study were tested using simple linear regression. Consequently, it was found that rebate had the highest significant positive effect on distributors’ performance, while trade allowance and dealers’ contest had the second and third-highest significant positive effects on distributors’ performance of FMCGs respectively. Therefore, the study concluded that trade sales promotion strategy has a significant positive influence on distributors’ performance in the context of fast-moving consumer goods (FMCGs). The study also made practical and theoretical implications for further research.
ANALISIS WACANA FEMINISME DALAM TEKS BERITA TABLOID NOVA
Authors:   Tadris Bahasa Indonesia, Institut Agama Islam Negeri Surakarta, Anggraini Nabila Syifa
Published: February 2022

The news text about feminism in the tabloid Nova can be used as a critical discourse analysis. This study aims to determine the position of women's news coverage and women's representation in tabloid Nova news texts. This study uses a qualitative descriptive method, with a critical discourse analysis approach. The data to be studied came from tabloid Nova, namely documents in the form of news texts on the August 2020 edition of the tabloid Nova. The data collection techniques in this study were carried out by reading and note-taking techniques. The data analysis technique in this study uses the Miles and Huberman model. The results of the analysis show that the discourse on feminism in the women's Nova tabloid occupies two positions at once, namely as an object (which is told) and also a subject (storyteller) and the presence of women's representation in it.
YANG INDIGENOUS, YANG KONTEMPORER, DAN YANG FUTURISTIK: DIMENSI SPIRITUAL CERPEN-CERPEN SETANGKAI MELATI DI SAYAP JIBRIL DANARTO
Authors:   HISKI (Himpunan Sarjana Kesusasteraan Indonesia) Komisariat Malang, PNS Dinas Pendidikan Provinsi Jawa Timur, Sudibyo Sudibyo
Published: February 2022

This article discusses the encyclopedic entry on the representation of spirituality in the short stories of Setangkai Melati di Sayap Jibril by Danarto. From the phenomenological analysis of the encyclopedic entries of spirituality representation in the short stories in the book, it can be stated that the spiritual dimension in Danarto's short story collection, for the way of representation, explores his spirituality inspiration through a number of encyclopedic entries. In simple terms, the various entries in the encyclopedia of spirituality can be mapped into four categories, namely (1) representations of spirituality that cultivate the myths of guardians in Java, (2) representations of spirituality that process wayang stories, (3) representations of spirituality that are spiritual from The guardian myth entries and the wayang world, both of them, are two indigenous encyclopedias, so the spiritual dimension in this collection of short stories can be mapped more simply into three entry categories, namely spirituality with indigenous encyclopedias, spirituality with contemporary encyclopedias, and spirituality with encyclopedias. futuristic. The distribution of the encyclopedic entries on the path of spiritual representation shows that the short stories in this book can be regarded as representations that maintain the meaning of spirituality in its essence, namely as something that has a single meaning, and at the same time shows that the representation of spirituality is something that is open to a variety of possible path choices.
RANCANG BANGUN SISTEM PEMINJAMAN DAN MANAJEMEN ASET LABORATORIUM BERBASIS IMPLEMENTASI RFID DAN APLIKASI WEB
Authors: Darwin Darwin , Budiyanta Nova Eka
Published: February 2022

ABSTRACT:Laboratories in university are one of the most essential facilities needed for academic activities. However, because of the Covid-19 pandemic, there is now restriction to access university laboratories. Students have lost their access to laboratory equipment. Based on this problem, a web application for equipment booking and laboratory asset management is made. The web application uses RFID technology with NodeMCU ESP8266 as its microcontroller, and CodeIgniter 4 framework.  The web application is evaluated by feature validation by the laboratory assistant head, white-box test and black-box test. White-box test uses Apache JMeter 5.3 to do load testing. The black-box test produces a functionality percentage of 82%, and from the white-box and feature validation we can conclude that the web application works well and is ready to be used.ABSTRAK:Laboratorium universitas merupakan salah satu fasilitas yang penting dalam kegiatan akademik. Namun dengan adanya pandemi Covid-19, akses laboratorium pada universitas dibatasi dan mahasiswa kehilangan akses penggunaan alat laboratorium. Berdasarkan masalah ini, aplikasi web peminjaman alat secara online dan manajemen laboratorium dibuat. Aplikasi berbasis web dilengkapi dengan RFID tapping tag pada alat, NodeMCU ESP8266 sebagai mikrokontroler dan CodeIgniter 4 untuk framework pengembangan aplikasi web tersebut. Sistem diuji dengan white-box test menggunakan Apache JMeter 5.3 sebagai load testing tool dan black-box test untuk menguji kelayakan aplikasi web seperti aspek fungsionalitas dan tampilan aplikasi, Hasil dari black-box test disimpulkan dari persentase kelayakan fungsional sistem yang diperoleh sebesar 82%. Dari hasil pengujian dapat dilihat bahwa sistem website peminjaman dapat bekerja dengan baik dan layak untuk digunakan.
DESIGN-BASED RESEARCH OU PESQUISA DE DESENVOLVIMENTO
Authors: Matta Alfredo Eurico Rodrigues , Silva Francisca de Paula Santos da , Boaventura Edivaldo Machado
Published: February 2022

Este artigo apresenta os fundamentos da metodologia de investigação e pesquisa mais conhecida como Design-Based Research (DBR), e que defendemos ter em português como o melhor termo de designação Pesquisa de desenvolvimento. O trabalho inicia contextualizando o porquê da adoção dessa abordagem metodológica, analisando como surgiu. Depois oferece orientação sobre como utilizar essa abordagem para a pesquisa e desenvolvimento de aplicações em várias áreas, mais propriamente para o desenvolvimento de propostas de processo cognitivo em ambientes digitais educacionais.
e-Learning in Medical Education in Sri Lanka: Survey of Medical Undergraduates and New Graduates
Authors: Samarasekara Keshinie
Published: February 2022

Background

Medical education has undergone drastic changes with the advent of novel technologies that enable e-learning. Medical students are increasingly using e-learning methods, and universities have incorporated them into their curricula.

Objective

This study aimed at delineating the pattern of use of e-learning methods among medical undergraduates and new graduates of the Faculty of Medicine, University of Colombo, and identifying the challenges faced by these students in using e-learning methods.

Methods

A cross-sectional descriptive study was conducted in the Faculty of Medicine, University of Colombo, in April 2020, with the participation of current undergraduates and pre-intern medical graduates, using a self-administered questionnaire that collected data on sociodemographic details, pattern of use of learning methods, and challenges faced using e-learning methods.

Results

There were 778 respondents, with a response rate of 65.1% (778/1195). All the study participants used e-learning resources with varying frequencies, and all of them had at least 1 smart device with access to the internet. Electronic versions of standard textbooks (e-books), nonmedical websites, online lectures, medical websites, and medical phone apps were used by the majority. When comparing the extent of use of different learning methods, it appeared that students preferentially used traditional learning methods. The preference was influenced by the year of study and family income. The 3 most commonly used modalities for learning new study material and revising previously learned content were notes on paper material, textbooks (paper version), and e-books. The majority (98.7% [n=768]) of participants have encountered problems using e-learning resources. The most commonly faced problems were unavailability of free-of-charge access to some e-learning methods, expenses related to internet connection, poor connectivity of mobile internet, distractions while using online resources, and lack of storage space on electronic devices.

Conclusions

There is a high uptake of e-learning methods among Sri Lankan medical students. However, when comparing the extent of use of different learning methods, it appeared that students preferentially used traditional learning methods. A majority of the students have encountered problems when using e-learning methods, and most of these problems were related to poor economic status. Universities should take these factors into consideration when developing curricula in medical education.
Reducing Treatment Burden Among People With Chronic Conditions Using Machine Learning: Viewpoint
Authors: Nagra Harpreet , Goel Aradhana , Goldner Dan
Published: February 2022

The COVID-19 pandemic has illuminated multiple challenges within the health care system and is unique to those living with chronic conditions. Recent advances in digital health technologies (eHealth) present opportunities to improve quality of care, self-management, and decision-making support to reduce treatment burden and the risk of chronic condition management burnout. There are limited available eHealth models that can adequately describe how this can be carried out. In this paper, we define treatment burden and the related risk of affective burnout; assess how an eHealth enhanced Chronic Care Model can help prioritize digital health solutions; and describe an emerging machine learning model as one example aimed to alleviate treatment burden and burnout risk. We propose that eHealth-driven machine learning models can be a disruptive change to optimally support persons living with chronic conditions.
Cancer Screening Recommendations During the COVID-19 Pandemic: Scoping Review
Authors: Shah Sumit K , McElfish Pearl A
Published: February 2022

Background

Cancer screening tests are recommended to prevent cancer-associated mortality by detecting precancerous and cancerous lesions in early stages. The COVID-19 pandemic disrupted the use of preventive health care services. Although there was an increase in the number of cancer screening tests beginning in late 2020, screenings remained 29% to 36% lower than in the prepandemic era.

Objective

The aim of this review is to assist health care providers in identifying approaches for prioritizing patients and increasing breast, cervical, and colorectal cancer screening during the uncertainty of the COVID-19 pandemic.

Methods

We used the scoping review framework to identify articles on PubMed and EBSCO databases. A total of 403 articles were identified, and 23 articles were selected for this review. The literature review ranged from January 1, 2020, to September 30, 2021.

Results

The articles included two primary categories of recommendations: (1) risk stratification and triage to prioritize screenings and (2) alternative methods to conduct cancer screenings. Risk stratification and triage recommendations focused on prioritizing high-risk patients with an abnormal or suspicious result on the previous screening test, patients in certain age groups and sex, patients with a personal medical or family cancer history, patients that are currently symptomatic, and patients that are predisposed to hereditary cancers and cancer-causing mutations. Other recommended strategies included identifying areas facing the most disparities, creating algorithms and using artificial intelligence to create cancer risk scores, leveraging in-person visits to assess cancer risk, and providing the option of open access screenings where patients can schedule screenings and can be assigned a priority category by health care staff. Some recommended using telemedicine to categorize patients and determine screening eligibility for patients with new complaints. Several articles noted the importance of implementing preventive measures such as COVID-19 screening prior to the procedures, maintaining hygiene measures, and social distancing in waiting rooms. Alternative screening methods that do not require an in-person clinic visit and can effectively screen patients for cancers included mailing self-collection sampling kits for cervical and colorectal cancers, and implementing or expanding mobile screening units.

Conclusions

Although the COVID-19 pandemic had devastating effects on population health globally, it could be an opportunity to adapt and evolve cancer screening methods. Disruption often creates innovation, and focus on alternative methods for cancer screenings may help reach rural and underresourced areas after the pandemic has ended.
The Impact of COVID-19 Pandemic on Health Care-Associated Infections in Intensive Care Units: Results From the Egypt National Health Care-Associated Infections Surveillance, 2019-2020
Authors: Roshdy Essam Mostafa , Attia Ehab , Samy Sahar , Afifi Salma , Abuelsood Hanaa , BahaaEldin Hala , Aied Alaa , Abdelfattah Mohammad
Published: February 2022

Background

The COVID-19 pandemic resulted in the unexpected influx of patients leading to high rates of hospitalization. Focusing resources to mitigate the pandemic unintentionally reduced attention to health care-associated infections (HAIs) prevention programs. Intensive care units (ICUs) have suffered the most burden due to requirement of ventilation.

Objective

In this paper, we aimed to estimate the national HAI rates at ICUs before and during the COVID-19 pandemic to better identify the pandemic’s impact on HAIs.

Methods

Egypt’s HAI Surveillance was established in 2016 in 177 governmental ICUs. CDC case definitions and questionnaire were used to collect patients’ data. The types of HAIs targeted included bloodstream infections, pneumonia, and urinary tract infections. Pathogen identification and antimicrobial resistance were performed at the central laboratory. Surveillance data 2019-2020 were obtained, and a descriptive data analysis was performed. HAI rates per 100 patient days and device-associated infections (DAIs) per 1000 device days were compared between 2019 and 2020.

Results

In 2020, 4028 HAIs were reported, including 777 (19.3%) ICU-acquired reports; however, in 2019, 6242 were reported, including 1084 (17.4%) ICU-acquired ones. Incidence significantly decreased in 2020 compared with 2019 (2.67 vs 2.72, P<.001). The percentages of bloodstream infections, pneumonia, and urinary tract infection in 2020, compared with 2019, were 64.0% versus 61.6%, 10.9% versus 12.1%, and 25.1% versus 23.8%, respectively. DAIs decreased significantly, including CLABSI (2.6 vs 2.5, P<.001), VAP (0.75 vs 0.87, P=.04), and CAUTI (1.5 vs 1.6, P=.02). Klebsiella spp. was the predominant pathogen in both years representing (35.6% and 38.1%), followed by S. aureus (11.2% and 15.4%). The rate of carbapenem-resistant K. pneumoniae insignificantly increased (25% vs 23%, P=0.3), and that of Methicillin-resistant S. aureus decreased (68% vs 70%, P=0.4).

Conclusions

Egypt’s HAI Surveillance successfully described the impact of COVID-19 pandemic on HAIs. It identified a significant decrease in ICU-acquired HAIs and DAIs at the first pandemic year, which could reflect better the infection control measures. The types of HAIs, causative pathogens, and antimicrobial resistance pattern did not change significantly. Surveillance should be maintained to guide HAIs’ preventive and control measures.
Depressive Symptoms and Anxiety During the COVID-19 Pandemic: Large, Longitudinal, Cross-sectional Survey (Preprint)
Authors: MacDonald James J , Baxter-King Ryan , Vavreck Lynn , Naeim Arash , Wenger Neil , Sepucha Karen , Stanton Annette L
Published: February 2022

BACKGROUND

The COVID-19 pandemic has influenced the mental health of millions across the globe. Understanding factors associated with depressive symptoms and anxiety across 12 months of the pandemic can help identify groups at higher risk and psychological processes that can be targeted to mitigate the long-term mental health impact of the pandemic.

OBJECTIVE

This study aims to determine sociodemographic features, COVID-19-specific factors, and general psychological variables associated with depressive symptoms and anxiety over 12 months of the pandemic.

METHODS

Nationwide, cross-sectional electronic surveys were implemented in May (n=14,636), July (n=14,936), October (n=14,946), and December (n=15,265) 2020 and March/April 2021 (n=14,557) in the United States. Survey results were weighted to be representative of the US population. The samples were drawn from a market research platform, with a 69% cooperation rate. Surveys assessed depressive symptoms in the past 2 weeks and anxiety in the past week, as well as sociodemographic features; COVID-19 restriction stress, worry, perceived risk, coping strategies, and exposure; intolerance of uncertainty; and loneliness.

RESULTS

Across 12 months, an average of 24% of respondents reported moderate-to-severe depressive symptoms and 32% reported moderate-to-severe anxiety. Of the sociodemographic variables, age was most consistently associated with depressive symptoms and anxiety, with younger adults more likely to report higher levels of those outcomes. Intolerance of uncertainty and loneliness were consistently and strongly associated with the outcomes. Of the COVID-19-specific variables, stress from COVID-19 restrictions, worry about COVID-19, coping behaviors, and having COVID-19 were associated with a higher likelihood of depressive symptoms and anxiety.

CONCLUSIONS

Depressive symptoms and anxiety were high in younger adults, adults who reported restriction stress or worry about COVID-19 or who had had COVID-19, and those with intolerance of uncertainty and loneliness. Symptom monitoring as well as early and accessible intervention are recommended.
Emotional Bias Modification for Individuals with Attention Deficit Hyperactivity Disorder: A Co-Design Study (Preprint)
Authors: Zhang Melvyn , Vallabhajosyula Ranganath
Published: February 2022

UNSTRUCTURED

Introduction
One of the common neurodevelopment disorders is that of attention deficit hyperactivity disorder (ADHD). Children with ADHD typically have difficulties with emotional regulation. Previous studies have investigated the assessment for underlying emotional biases by using the visual probe task. However, one of the major limitations of the visual probe task is that it is onerous and repetitive over time. Prior research has examined the use of gamification methods in addressing the limitation of the emotional bias visual probe task. There has also been increased recognition of the potential of participatory action research methods, and how it could help make conceptualized interventions more relevant.
Objective
The primary aim of this study was in collating healthcare professionals’ perspective on the limitations of the existing visual probe task, and to determine if gamification elements were viable to be incorporated.
Methods
A co-design workshop was conducted. Healthcare professionals from the Department of Development Psychiatry, Institute of Mental Health, Singapore were invited to participate. Participants were asked to identify limitations and to suggest potential methods to overcome some of the identified limitations. Subsequently, participants were shown examples of existing gaming interventions in the published literature and on commercial stores. They were asked to comment on the advantages and limitations of these interventions. Finally, participants were asked if the inclusion of gamification techniques would be appropriate.

Results
4 healthcare professionals consented and participated. Several limitations were identified with regards to the conventional emotional bias intervention. These included the nature of the task parameters, the included stimulus set, and factor that could have an impact on the accuracy of responding to the task. In the examination of existing ADHD games, participants raised concerns pertaining to the evidence base of some of the applications and articulated that any developed ADHD game ought to clearly identify the specific skill set that was targeted. For gamification strategies, participants preferred economic and performance-based gamification approaches.
Conclusions
This study has managed to elucidate healthcare professionals’ perspectives towards the refinement of a conventional emotional bias intervention for individuals with ADHD.