bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PERSEPSI TENTANG KUALITAS LAYANAN TERHADAPKEPUASAN KONSUMEN PADA UD. MUKTI JAYA JEMBER
Authors: Andrean Mohammad Ongky , Hermawan Haris , Sari Maheni Ika
Published: April 2024

Performance decisions get better, namely the goal for all employees to want to achieve the targets that have been set. The purpose of this study was to determine the Perception Analysis and Consumer Satisfaction at UD. Mukti Jaya Jember. The population used in this research is UD consumers. Mukti Jaya Jember. The sample used was 82 respondents, using a non-probability sampling technique. The data analysis technique uses multiple linear regression analysis. The results of this study indicate that the Perception Analysis variable has a significant effect on consumer satisfaction. Suggestions in this study is that companies can increase customer satisfaction.
PENGARUH MARKETING MIX TERHADAP KEPUTUSAN PEMBELIAN DEALER MOKAS SEMERU MOTOR DI MASA PANDEMI
Authors: Sani Muhammad Mahrus , Hafidzi Achmad Hasan , Reskiputri Tatit Diansari
Published: April 2024

Purchasing decisions become better, namely the goal for all employees to want to achieve larger purchasing targets. The purpose of this study was to determine the effect of the marketing mix on purchasing decisions for Mokas Semeru Motor dealers during the pandemic. the covid-19 pandemic has greatly affected the level of sales of Mokas Semeru. We can see the sales data in May with sales of only 6 units of motorbikes because in that month the Covid-19 pandemic was endemic, especially in Jember Regency plus in May it collided with the month of Ramadan so that people are more concerned with daily needs than complementary needs like a motorcycle. The population used in this study were all consumers of Mokas Semeru Motor Dealers. The sample used was 125 respondents, using a non-probability sampling technique. The data analysis technique uses multiple linear regression analysis. The results of this study indicate that the Marketing Mix variable has a significant effect on purchasing decisions during a pandemic. Shows a good and appropriate assessment of the indicators Mokas Semeru Dealers offer used motorcycle products at prices that are in accordance with the condition of the unit, Mokas Semeru Dealers offer used motorcycle products according to market prices, and Mokas Semeru Dealers offer used motorcycle products at affordable prices. The suggestion in this study is for mokas dealers to increase marketing towards purchasing decisions during a pandemic. The variables in this study explain the frequency distribution of respondents' answers about the indicators contained in this research questionnaire statement, namely Product (X1), Price (X2), Place (X3), Promotion (X4), HR (X5), Process (X6 ), Physical Evidence (X7), and Purchase Decision (Y). The scores given by respondents to each statement in the questionnaire reflect how they perceive the research variables.
PENGARUH MANAJEMEN LABA, UKURAN PERUSAHAAN, DAN KINERJA LINGKUNGAN TERHADAP PENGUNGKAPAN CORPORATE SOCIAL RESPONSIBILITY (CSR) PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI)
Authors: ‘Asyiiroh Vindy Abdatul , Amani Tatik , Rustianawati Mutimmah
Published: April 2024

Penelitian ini bertujuan untuk mengetahui pengaruh dari manajemen laba, ukuran perusahaan, dan kinerja lingkungan terhadap pengungkapan Corporate Social Responsibility (CSR) pada perusahaan manufaktur yang terdaftardi Bursa Efek Indonesia. Jenis atau metode yang digunakan yaitu kuantitatif, dengan menggunakan variabel bebas yaitu manajemen laba, ukuran perusahaan, dan kinerja lingkungan. Variabel terikatnya ialah pengungkapan Corporate Social Responsibility (CSR). Penelitian ini menggunakan uji hipotesis dengan fokus penelitian pada Laporan Tahunan perusahaan manufaktur makanan dan minuman yang terdaftar di Bursa Efek Indonesia (BEI) periode 2017-2021. Sampel dalam penelitian ini ialah 10 perusahaan makanan dan minuman. Pemilihan sampel menggunakan metode purposive sampling. Hasil penelitian menunjukkan bahwa pengaruh secara parsial  manajemen laba tidak mempunyai pengaruh yang signifikan terhadap pengungkapan CSR, sedangkan ukuran perusahaan dan kinerja lingkungan mempunyai pengaruh yang signifikan terhadap pengungkapan CSR. Secara simultan manajemen laba, ukuran perusahaan, dan kinerja lingkungan mempunyai pengaruh yang signifikan terhadap pengungkapan CSR. Sedangkan yang mempunyai pengaruh secara dominan terhadap pengungkapan CSR adalah kinerja lingkungan.
ANALISA DAN DESAIN SISTEM INFORMASI PEMASARAN PADA KEGIATAN UMKM BERBASIS KLASTER
Authors: Widiarti Dian , Praja Yudha
Published: April 2024

Small and medium enterprises (MSMEs) are businesses that aim to provide economic services to consumers in order to generate income for the community and promote economic growth. In order to compete in today's tight business world, MSMEs need to innovate and adapt to the digital age. However, many MSMEs in Dawuhan Village face challenges such as limited product branding and market reach. The goal is to help MSMEs market their products more effectively and reach a wider audience. To address this issue, a marketing information system was developed using data from MSME owners in one cluster. The research involved surveying the initial conditions of MSME activities, analyzing system requirements, designing the system, and implementing it iteratively. The result is a design for a marketing information system that includes system requirements analysis, use case diagrams, sequence diagrams, database design, and website interface design.
EVALUASI SISTEM INFORMASI AKUNTANSI PEMBELIAN DAN PENJUALAN PADA BISNIS KUINER (STUDI KASUS PADA OUTLET MIE SAKERA CABANG DANAU TOBA)
Authors: Maulida Vika Intan , Halim Moh. , Aspirandi Rendi Mirwan
Published: April 2024

An accounting information system is a system that provides accounting and financial information along with other information obtained from routine accounting transaction processes. The information produced by the accounting information system includes, among other things, information regarding sales orders, cash receipts, purchase orders, payments and payroll. Based on analyzing the system running at the Mie Sakera Caban Lake Toba Jember business and looking at the existing problems, it is necessary to create a Web-based or computer-based Product Sales Information System, namely a system which helps the operational sales process in a systematic manner starting from inventory data and sales data which has been carried out automatically by the user so as to produce output in the form of information that is useful for the owner. This system must be designed so that it can access data easily, in a comprehensive system starting from inventory data, sales data as well as simplifying the product sales process with extensive promotions and an effective and efficient reporting process by integrating data through a database.
PENGARUH HARGA CRUDE PALM OIL (CPO), MINYAK DUNIA DAN FOREIGN DIRECT INVESTMENT (FDI) TERHADAP PERTUMBUHAN EKONOMI DI ASIA TENGGARA DITINJAU DARI PERSPEKTIF EKONOMI SYARIAH
Authors: Sulastri Sri Irma , Andika Sandi
Published: April 2024

Economic growth in a country is an important aspect of economic development. International trade (export-import) such as crude palm oil, world crude oil and investment such as foreign direct investment is one of the factors that affect economic growth in a country. This study aims to determine and analyze the effect of crude palm oil (CPO) prices, world oil and foreign direct investment (FDI) on economic growth in Southeast Asia from an Islamic economic perspective. The method used is descriptive quantitative. The population is 10 countries in Southeast Asia, the sample in this study uses a purposive sampling technique, the sample is 5 countries which include Malaysia, the Philippines, Cambodia, Singapore and Indonesia with a period of 6 years from 2016-2021. The data analysis method uses panel data regression with 3 approaches to model selection, namely the Chow test, Hausman test and Langrange multiplier test which produces a random effect model (REM). The output results of the REM model show that among the five sample countries the most influential country on economic growth in ASEAN is Indonesia with an equation value of 9.29. The results of the study partially show that the CPO variable with a t-count value of 0.776 > t-table -1.705, then the WTI variable with a t-count value of 2.244 > t-table -1.705 and the FDI variable with a t-count value of 0.272 > t-table -1.705 which states that these three variables have a positive and significant effect on economic growth. Simultaneously, an f-count value of 3.665 > f-table 0.015 is obtained, which means that the independent variables (CPO, WTI, FDI) together have a significant effect on the dependent variable, namely economic growth. The coefficient of determination (R2) shows that CPO, WTI and FDI are able to contribute 21.6%.
PERCEIVED VALUE SEBAGAI MEDIASI PENGARUH E-SERVICESCAPE TERHADAP LOYALITAS PELANGGAN
Authors: Faiza Nur , Rachman Riza
Published: April 2024

The online shop has become a popular trend in shopping for various groups of people in Indonesia, providing convenience for consumers to make transactions from anywhere. The purpose of this research is to empirically examine and prove the influence of e-servicescape on shopping on the Shopee marketplace in increasing customer loyalty, test the influence of e-servicescape in increasing perceived value, examine the influence of perceived value in increasing customer loyalty, and test the magnitude of the influence of e-servicescape on customer loyalty through perceived value as a mediating variable. The research method used quantitative methods by conducting a survey of 170 Shopee marketplace users in East Java. The research data were analyzed using Partial Least Square (PLS) operated through the SmartPLS program. The results show that e-servicescape has a significant influence on customer loyalty, e-servicescape has a significant influence on perceived value, perceived value has a significant influence on customer loyalty, and perceived value mediates the relationship between e-servicescape and customer loyalty. Several suggestions and directions are also provided to expand research as a discussion topic.
PENGARUH KUALITAS PRODUK, KUALITAS PELAYANAN DAN HARGA TERHADAP MINAT BELI SEPEDA MOTOR LISTRIK PADA DEALER CV JAYA TERANG DI SITUBONDO
Authors: Ediyanto Ediyanto , Minullah Minullah
Published: April 2024

The aim of this study to determine the effect of product quality, service quality and price variables partially on the variable buying interest of electric motorcycle on dealer CV Jaya Terang in Situbondo, to determine the effect of product quality, service quality and price variables simultaneously on variables interest in buying electric motorcycle on dealer CV Jaya Terang in Situbondo, to adhere to the influence of product quality, service quality and price variables that have a dominant influence on the interest of buying electric motorcycle on dealer CV Jaya Terang in Situbondo. The method used is quantitative. The results of the study are multiple linear regression equation Y = -1,104E-16 + 0,373X1 + 0,261X2 + 0,305X3 + e. Partially, product quality has a positive effect with tcount 4,112> ttable 1,985 sig value 0,000<0,05, service quality shows tcount value 3,479> ttable 1,985 sig value 0,001 <0,05, price indicates ttest value 3,420> ttable 1,985 sig value 0,001 <0,05. Simultaneously the product quality, service quality and price affect buying interest with a value of Fcount 31,509> Ftable 2,70. The most influential dominant variable in this study is product quality with a value of 4,112 greater than the service quality variable (X2) and the price variable (X3). Based on the coefficient of determination shows a value of 0,501 of the results means that all independent variables have a contribution of 50,1% to the dependent variable that has sufficient influence and the remaining 49,9% is influenced by other factors not included in the study.
PENGARUH BRAND EQUITY TERHADAP KEPUTUSAN PEMBELIAN KONSUMEN THRIFT SHOPPING PADA MAHASISWA UNIVERSITAS ABDURACHMAN SALEH SITUBONDO
Authors: Sari Rini Kartika , Sari Lita Permata
Published: April 2024

The development of the fashion industry is undergoing a rapid increase, even fashion trends can change every monthly period. Existing information technologies are becoming a means of conveying information about changes in current fashion trends, which can influence different points of view and opinions about dressing in appearance. Everyone has a different lifestyle or distinctive features of each in appearance. The existence of Thrift shopping is one of the alternative ways of the fashion world through the purchase of used clothes. The emergence of this second-hand item, becomes an opportunity for teenagers who want to remain fashionable but at a minimum price, so that it is accessible to teenagers. This study is descriptive with a quantitative approach to prove the existing hypothesis regarding the influence of Brand Awareness, Brand Association, Perceived Quality, and Brand Loyalty on thrift shopping purchase decisions in students at Abdurachman Saleh Situbondo University. Based on the results of the F (simultaneous) Test study, which showed a significant value of 0.000 is below 5%. This means that Brand Awareness, Brand Association, Perceived Quality, and Brand Loyalty influence students to behave thrift shopping in students at Abdurachman Saleh Situbondo University. Test t (partial), Brand Awareness, Brand Association, Perceived Quality, and Brand Loyalty had a positive and significant effect on thrift shopping purchase decisions in students at Abdurachman Saleh Situbondo University.
ANALISIS KUALITAS SUMBER DAYA MANUSIA DALAM PERILAKU KEUANGAN IBU RUMAH TANGGA LINGKUNGAN PERUMNAS PATRANG KOTA JEMBER DI ERA DIGITALISASI
Authors: Pramesthi Riska Ayu , Karnadi Karnadi
Published: April 2024

The quality of human resources in the financial behavior of housewives in the era of digitalization, the existence of digital media (market place) and free online loan applications, makes housewives unable to control their household's financial behavior which leads to various problems such as money running out prematurely. , do not have regular savings in the form of saving money or in financial institutions, and do not have an emergency fund. In fact, it is not uncommon to find many family members who are in debt or borrow money from banks, neighbors or from agents where money is borrowed. The aim of this research is to determine and analyze the management of the quality of human resources in the financial behavior of housewives in the Perumnas Patrang Environment, Jember City. The method in this research uses a qualitative approach with a survey type. Data collection in research uses observation and interviews. The findings obtained from the lack of knowledge about financial management among housewives will have an impact on the economy of the perpetrators, especially in the current era of digitalization.
ANALISIS KINERJA KEUANGAN DALAM MEMPREDIKSI FINANCIAL DISTRESS PADA SUB SEKTOR PERBANKAN YANG TERDAFTAR DI BURSA EFEKINDONESIA (BEI)
Authors: Jannah Raudatul , Endang Lusi , Norma Nike , Amriani Siti Dwi
Published: April 2024

The research is to analyze the influence of the variables Liquidity, Profitability and Free Cash Flow on Financial Distress. The research that has been carried out has obtained less consistent results from one study to another. This research uses the banking subsector listed on the Indonesia Stock Exchange (BEI) during 2020-2022, so the research sample in this study used the purposive sampling method to produce 5 sample companies and the samples were carried out over a period of 3 years so that the sample was 15. This hypothesis testing uses multiple linear regression analysis using the SPSS application.

The results show that in the analysis of the influence on Financial Distress there is an influence and no influence between other world variables, namely Liquidity and Free Cash Flow, which do not have a significant influence on Financial Distress. And one Profitability Variable has a positive and significant effect on Financial Distress. The results of testing Liquidity, Profitability and Free Cash Flow simultaneously have a positive and significant effect on Financial Distress.
PERILAKU MANAJEMEN KEUANGAN PEDAGANG PEREMPUAN DI PASAR KALISAT KABUPATEN JEMBER
Authors: Safira Serli Vebriana , Supeni Retno Endah , Sari Maheni Ika
Published: April 2024

The phenomenon that occurs to female traders in the Kalisat market is financial knowledge where traders in the Kalisat market do not understand how to manage finances properly even though the proceeds from their sales are set aside to be saved every day. The researcher intends to measure the financial management behavior of female traders in the Kalisat market, Jember district by raising variables regarding financial management which refer to financial knowledge, income, financial attitude, personality and financial management behavior. The data obtained by distributing questionnaires through the Google Form. The population measurement was conducted by interviewing the head of the market management and the results obtained were 1,520 female traders. The sampling technique used the Slovin formula and the results obtained were 320 respondents with the criteria of being female, aged over 17 years and trading for more than 5 years. The method is a quantitative approach with multiple linear regression tests. The results of the study stated that the financial management behavior of female traders in the Kalisat market in Jember district was positively and significantly influenced by the variables of financial knowledge, income, financial attitudes, and personality.
PENGARUH INOVASI PRODUK, BRAND IMAGE, DAN DESAIN TERHADAP KEPUTUSAN PEMBELIAN SEPEDA MOTOR VARIO DI KECAMATAN AMBULU
Authors: Dita Amelia Violan , Septianingsih Wahyu Eko , Rahayu Jekti
Published: April 2024

Tujuan dari penelitian ini adalah untuk mengetahui dan menganalisis pengaruh inovasi produk, brand image, dan desain terhadap keputusan pembelian sepeda motor vario di Kecamatan Ambulu. Penelitian ini menggunakan metode penelitian deskriptif dan kuantitatif korelasional. Populasi pada penelitian ini yaitu masyarakat pengguna sepeda motor vario 125 di Kecamatan Ambulu dan sampel yang digunakan sebanyak 70 responden. Teknik pengambilan sampel menggunakan teknik accidental sampling dimana sampel dipilih ketika bertemu dengan peniliti saat penelitian atau pengambilan sampel yang dapat dilakukan sewaktu-waktu sampai jumlah sampel terpenuhi. Data yang digunakan yaitu data primer melaui kuesioner dan wawancara. Teknik analisis data dilakukan dengan analisis regresi linier berganda menggunakan SPSS versi 22. Hasil penelitian menunjukkan bahwa inovasi poduk secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian sepeda motor vario di Kecamatan Ambulu. Brand image secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian sepeda motor vario di Kecamatan Ambulu. Desain secara parsial berpengaruh positif dan signifikan terhadap keputusan pembelian sepeda motor vario di Kecamatan Ambulu.
MEMBANGUN KESEJAHTERAAN DAN KESEHATAN KEUANGAN MELALUI PENDEKATAN AKUNTANSI SYARIAH DI DINAS KESEHATAN KOTA MEDAN
Authors: Husna Rifdah Nur , Kamilah K
Published: April 2024

Healthy and sustainable financial management is the main focus in efforts to improve community welfare, especially in the health sector. One approach that can be used is sharia accounting, which prioritizes the principles of justice, transparency and sustainability in financial management. This study aims to analyze how the implementation of sharia accounting in the Medan City Health Service can help build financial prosperity and health. The research method used is a case study by collecting data through interviews, observation and document analysis. The research results show that the implementation of sharia accounting in the Medan City Health Service has made a positive contribution in building community welfare through more transparent, efficient and sustainable financial management. However, further efforts are still needed to optimize the benefits of implementing sharia accounting in improving overall financial welfare and health.
PENGARUH PELATIHAN PENYUSUNAN LAPORAN KEUANGAN TERHADAP PERSEPSI KEMUDAHAN IMPLEMENTASI AKUNTANSI DAN MANFAAT INFORMASI AKUNTANSI (Studi pada Usaha Mikro Kecil dan Menengah di Kabupaten Jember)
Authors: Putri Nailah Cahaya , Yuliarti Norita Citra , Martiana Nina
Published: April 2024

Micro, Small and Medium Enterprises (MSMEs) have an important role in the country's economic movement. Moreover, in the current era, the MSME population is 65.64 million people and is predicted to increase every year. MSMEs experience many obstacles, such as during the pandemic, competition and financial problems. In terms of financial matters, there are still many MSMEs who do not keep accounting records. Lack of knowledge about accounting hinders business management, making it difficult for them to decide which policies to implement. Many entrepreneurs don't understand bookkeeping, which makes accounting decision making difficult. To encourage MSMEs to use accounting, it is necessary to start by fighting the MSMEs themselves. Financial reports are very important for businesses because they can provide relevant and accurate decision making information. Well-prepared financial reports can assist in making strategic decisions and provide a clear picture of a company's financial performance. However, in practice, many challenges arise when preparing financial reports. This research was conducted in Jember Regency with a population of 219 MSMEs and a sample size of 24 MSMEs. The results of this research are that simultaneously training in preparing financial reports (X) has no effect on the perception of ease of implementation of accounting (Y1) and at the same time the benefits of accounting information (Y2).
PENGARUH PELATIHAN KERJA, KOMITMEN, DAN DISIPLIN KERJA TERHADAP KINERJA KARYAWAN PT. PLN (PERSERO) UNIT LAYANAN PELANGGAN KECAMATAN ASEMBAGUS KABUPATEN SITUBONDO
Authors: Soleha Maulidatul Amaliatus , Soeliha Siti
Published: April 2024

This research aims (1) to determine the partial influence of work training variables, commitment variables and work discipline variables on employee performance at PT. PLN (Persero) Customer Service Unit, Asembagus District, Situbondo Regency (2) To determine the effect of job training variables, commitment variables and work discipline variables simultaneously on employee performance at PT. PLN (Persero) Customer Service Unit, Asembagus District, Situbondo Regency (3) To determine the influence of job training variables, commitment variables and work discipline variables which have a dominant influence on PT employee performance. PLN (Persero) Customer Service Unit, Asembagus District, Situbondo Regency. The method used is quantitative. The research result is a multiple linear regression equation Y = 2.025 + 0.332 + 0.341 + 0.352 + e. partially Job Training has a significant positive effect with a tcount value greater than ttable 2.270 > 2.042 or sig α 0.031 < 0.05, Commitment shows a tcount value greater than ttable 2.333 > 2.042 or sig α 0.027 <0.05, Work Discipline shows a value tcount is greater than ttable 2.436 > 2.042 or sig α 0.021 <0.05 Recruitment, Job Training and Position Promotion simultaneously influence the Performance of Civil Servants at the Bondowoso Regency Revenue Agency which is acceptable with a calculated F value of 6.157, a value greater than F table namely 2.92 or F count 6.157 > F table 2.92. The Work Discipline variable has the most dominant influence on Employee Performance with a value of 2.436.
Investigation of the Effect of CFRP and GFRP Sheet Length on the Final Capacity of Reinforced Concrete Beams of Buildings in Coastal Areas
Authors:   Department of Civil Engineering, Islamic Azad University (Science and Research), Neyshabour, Iran, Mashhadi Ali-Rasoulian , Varastehpour Hamid ,   Higher Education Complex Utilities Industry in Khorasan, Mashhad, Iran, Ghassemizadeh Seyed-Mahmood ,   MSc Graduate, Department of Maritime Engineering, Amirkabir University of Technology, Tehran, Iran
Published: April 2024

In the last two decades, the use of FRP (Fiber Reinforced Polymer) composites for flexural, shear, torsion, and enclosing reinforcement of various structural components has grown exponentially. In this paper, the effect of using FRP composite with carbon fibers and glass with different lengths on the behavior of reinforced concrete beams is investigated. Eight reinforced concrete beams with a length of 150 cm, a width of 15 cm, and a height of 20 centimeters were modeled by composite fibers with lengths of 80 cm, 100 cm, 120 cm and 140 centimeters. Then, the sample reinforced concrete beam was modeled in ABAQUS® , which the results were compared with the laboratory samples. It were observed that with increasing the length of FRP sheets, the strength of reinforced concrete beams compared to the sample concrete beam, increased by about 61%, 82%, 86%, and 87%, respectively. It was due to the high cost of FRP sheets and compressive strength required in these sheets that used optimally. Therefore, the length of FRP strengthening sheets can be optimized to reduce the cost of FRP sheets and use them efficiently.
Potential Optimization of Industrial Waste as an Alternative Material for Composite Filler in Brake Pad Manufacturing – A Review
Authors:   Master Student in Mechanical Engineering, Universitas Riau, Indonesia, Sativa Oriza , Nawangsari Putri ,   Mechanical Engineering, Universitas Riau, Indonesia
Published: April 2024

This study investigates the sustainable utilization of fly ash, palm slag and Cement By-Pass Dust (CBPD) waste as alternative materials for environmentally friendly brake pad development. These waste materials, with compositions similar to Asbestos, historically used in brake pad composites, present an eco-conscious solution. Integrating industrial waste in brake pad production offers substantial environmental benefits, technological progress, and commercial advantages. The compaction value and particle size distribution significantly impact brake pad mechanical properties. Adjusting these factors is crucial for meeting desired mechanical property requirements. A large particle size distribution enhances material density and hardness poses challenges in maintaining performance stability at high temperatures despite good recovery values. This paper highlights the potential of waste materials for sustainable brake pad development and underscores the need for careful optimization for high-temperature stability.
A Systematic Review of Optimal Power Flow Studies with Renewable Energy Sources Penetration
Authors:   Doctoral Student in Department of Electrical Engineering, Universitas Andalas,West Sumatra,Indonesia, Maulana Ricky , Syafii Syafii ,   Department of Electrical Engineering, Universitas Andalas, West Sumatra, Indonesia
Published: April 2024

The increasing penetration Renewable Energy Source (RES) in electrical power grid, the power system must minimize costs and comply with operational and safety requirements. Optimal power flow (OPF) contributes to this objective by determining the optimal control settings, satisfying system and safety constraints, and enhancing operational efficiency. A systematic review was conducted to assess how OPF studies have been evaluated in the literature. The review analyzed 64 journal articles to identify specific OPF studies from three perspectives: type of RES penetration, objective function, and method of OPF. The results indicate that (a) wind turbines are the most commonly used RES model in OPF studies, (b) cost function is the primary objective that the majority of research has considered, and (c) novel meta-heuristics have often been used in OPF methods under uncertain RES penetration. This systematic review identifies research gaps and topics for further research to study OPF with RES penetration. The findings are expected to benefit researchers in deciding the best OPF method under uncertain RES.
Design of Air Blast Freezing System Using Cascade Refrigeration R290/R32 System with Capacity 5kg
Authors:   Mechanical Engineering Department, Universitas Riau, Indonesia, Martin Awaludin , Nasution Fikri-Fahlevi ,   Magister Student in Mechanical Engineering, Universitas Riau, Indonesia, Mainil Rahmat-Iman ,   Mechanical Engineering Department, Universitas Riau, Indonesia
Published: April 2024

Indonesia is a maritime country that has an abundance of marine catches. In 2022, the production of marine catches reached 24.85 millions tons, while the export amount was 1.221 millions tons. This is due to the limited technology that can extend the freshness of marine catches. Based on this problem, a cooling system was designed in the form of an ABF that can freeze marine catch products. The Air Blast Freezing (ABF) system is designed at an air temperature of -40oC using a cascade refrigeration system. The working fluid used is R290/R32 hydrocarbon, which has very low GWP and ODP so it is safe for the environment and the earth's ozone layer. The results obtained show that the cooling load is 444.037 Watts, the LTC compressor power and HTC compressor power are 116.19 Watts and 205.98 watts. The designed air blast freezing system has a surface area of LTC evaporator of 2.670 m2 and HTC condenser of 4.780 m2. The calculated capillary pipe length is 1.94 m for HTC and 1.51 m for LTC, the COP of the ABF system is 2.774.
Bottom-up and top-down VAT photopolymerization bioprinting for rapid fabrication of multi-material microtissues
Authors: Nieto Daniel , Jorge de Mora Alberto , Kalogeropoulou Maria , Bhusal Anant , K. Miri Amir , Moroni Lorenzo
Published: April 2024

Over the years, three-dimensional (3D) bioprinting has attracted attention for being a highly automated manufacturing system that allows for the precise design of living constructs where cells and biomaterials are displaced in predefined positions to recreate cell–matrix and cell–cell interactions similar to native tissues. Such technologies rarely offer multi-material features. In this paper, we present a new approach for bioprinting of multi-material tissue constructs using VAT photopolymerization at high resolution and fidelity. We developed a versatile dual-mode bioprinter that can easily be modulated to print in both top-down and bottom-up approaches. The custom-built platform was then used to fabricate microtissues and hydrogel microfluidic models. Combining bottom-up and top-down biofabrication tools can offer an optimal solution for hard–soft multi-material composites and for bioprinting tissue–tissue interface models. We demonstrated the possibility for hard–soft multi-material bioprinting by generating musculoskeletal tissue with integrated microvasculature. Combining multiple material bioprinting and microfluidic chips shows advantages in two aspects: precise regulation of microenvironment and accurate emulation of multi-tissue interfaces.
A parallel multilayered neurovascular unit-on-a-chip for modeling neurovascular microenvironment and screening chemotherapeutic drugs
Authors: Xu Yuanyuan , Kong Dongsheng , Zhang Ting , Xiong Zhuo , Sun Wei
Published: April 2024

 Humans are grappling with increasing occurrence rate of brain tumors, which are associated with unfavorable prognosis and cognitive neurotoxicity caused by chemotherapy. Ideally, therapeutic drugs for brain tumors should efficiently suppress the tumors while minimizing neurotoxic effects. To facilitate drug development, in vitro pathological models of human brain tumors are essential. Here, we engineered a sophisticated human neurovascular unit (hNVU) chip that simulates the microenvironment of pediatric brain using three-dimensional bioprinting technology. The hNVU chip featured a multilayer parallel architecture composed of a biomimetic blood–blood barrier (BBB) and brain region. An automated perfusion system in the chip simulated the blood flow within the brain. The specialized liquid channels within the brain region enabled comprehensive analysis of drug metabolites. The blood–brain barrier (BBB) structure is composed of endothelial cells, pericytes, and astrocytes, and the brain region contains endothelial cells, pericytes, astrocytes, microglia, and neural progenitor cells, representing the cellular components found in pediatric brain. To replicate the basal membrane, we utilized GelMA (gelatin methacryloyl), gelatin, and laminin as primary bioinks, with the addition of fibrin to mimic the pathological characteristics of brain extracellular matrix (ECM). The BBB membrane exhibited a maximum electrical resistance of 360 Ω cm2 and demonstrated impressive semipermeability by effectively blocking the permeability of large molecules with a molecular weight of 10 kDa. Gene expression analysis and immunofluorescence staining revealed a gradual increase in COL4A1 and fibrin, indicating remodeling of the ECM by the cells. Astrocytoma cells (SF188) were introduced in the model to construct a neurovascular unit containing pediatric brain tumor cells. We evaluated the therapeutic effects and toxicity profiles of chemotherapeutic drugs, including vorinostat and 5-fluorouracil. Encouragingly, our investigations revealed that vorinostat not only exhibited remarkable tumor-suppressing efficacy but also induced lower neurocognitive toxicity than 5-fluorouracil. In summary, the hNVU chip served as a reliable and versatile platform for conducting comprehensive studies on the therapeutic effects of chemotherapy drugs for brain tumors.
Bioprinted autologous human skin equivalents for in vitro testing of therapeutic antibodies
Authors: Ahmed Mahid , Hill David , Ahmed Shaheda , Przyborski Stefan , Dalgarno Kenneth , Dickinson Anne
Published: April 2024

In recent years, advances in tissue engineering have brought forward the accessibility of human skin equivalents for in vitro applications; however, the availability of human-based engineered tissue models suitable for high-throughput screening of biologics remains limited. Here, we report a method of manufacturing fully autologous (with both fibroblasts and keratinocytes from the same donor) human skin equivalents for determining preclinical therapeutic antibody adverse immune reactions in vitro. Using a combination of precise solenoid microvalve-based bioprinting and 96-well scale Alvetex inserts, autologous skin cells were bioprinted and cultured to develop a scalable approach to manufacturing skin equivalents. We demonstrated that fibroblasts and keratinocytes can be bioprinted with a high degree of precision while maintaining viability post printing. Histological staining showed that the bioprinted 96-well based skin equivalents were comparable to human skin. The fully autologous human skin equivalents were co-cultured in vitro with autologous peripheral blood monocytes with and without muromonab-CD3 (OKT3) and natalizumab (Tysabri), biologics which are known to cause and inhibit adverse immune reactions (type IV hypersensitivity), respectively. Analysis of supernatants from skin-equivalent monocyte co-cultures revealed significant proinflammatory cytokine responses (such as interferon gamma) in co-cultures treated with OKT3 when compared to Tysabri and negative controls. Consequently, this study provides proof of concept that through a combination of bioprinting and Alvetex scaffold-based culture systems, scalable human skin equivalents can be manufactured for high-throughput identification of adverse immune reactions during preclinical stages of the drug development process.
Current advances of 3D-bioprinted microfluidic models with hydrogel bioinks and their applications in drug screening
Authors: Li Jianing , Li Na , Liu Bo , Li Shen , Zhang Hangyu
Published: April 2024

Microenvironments of tumor and organ models dictate the accuracy of drug screening results. The advancement of technologies and hydrogel bioinks has significantly increased the representation of tumor and organs models in the armada of drug testing tools. Hydrogel bioinks, characterized by their high water content and efficient substance transport, facilitate the reconstruction of human tissues by acting as functional carriers for cells. The molding and cell culture function of hydrogels are preserved and optimized through rational engineering techniques. Furthermore, previous studies have often focused on fabrication of supporting constructs by means of three-dimensional (3D) bioprinting or microfluidic technology for dynamic cultures. Nevertheless, the combination of bioprinting and microfluidic technologies offers advantages in terms of dynamic response and automation, which enable the creation of artificial tumor or organ models to represent actual microenvironments. In this review, we discuss the components and physical features of tumor microenvironments (TMEs), most of which have been reproduced in artificial models widely by different researchers. We also classify bioink-simulating extracellular matrix (ECM) in TMEs, explain their crosslinking principles, and introduce their manifestations, including artificial disease or organ models in tissue engineering application. Technologies, such as 3D bioprinting and microfluidic technology, used to create these models are also outlined. At last, we summarize disease models and organ microarchitectures fabricated by these two technologies and offer application prospects of these models in the realm of precision medicine.
Evaluating the clinical benefit and acceptance of a bespoke 3D-printed splint for the treatment of mallet finger injury: A pilot study in a cohort of patients
Authors: M. Cronin Una , O’Sullivan Aidan , Sheerin Margo , J. O’Sullivan Kevin , M. Cummins Niamh , Ryan Damien , W. O’Sullivan Leonard
Published: April 2024

Mallet finger injuries due to forced flexion of the distal interphalangeal joint represent a common reason for hospitalization. These injuries are primarily managed using generic Stack splints. The gold standard of care is custom splinting by a specialized hand therapist. However, this is not widely available due to staffing constraints. The aims of this study are to: (i) evaluate whether treating mallet finger injuries with a custom three-dimensional (3D)-printed splint is clinically beneficial, and (ii) assess patient and healthcare professional (HCP) acceptance and experience of bespoke 3D-printed mallet splints over generic splints. Ten adult patients with closed mallet finger injury were recruited in this study, which was conducted across three Injury Units in the University of Limerick Hospital Group (ULHG). Each patient’s injured finger was measured using calipers and subsequently fitted with a bespoke 3D-printed splint. Clinical benefit and acceptance of bespoke 3D-printed splints for the treatment of mallet finger injury was assessed. The results indicate that it is clinically advantageous to use a custom 3D-printed splint over a premolded generic splint. Out of the ten patients recruited, eight had successful outcomes based on the occupational therapist (OT) measurements using the Crawford classification scale. The results showed that 40% of patients scored excellent, 30% good, 30% fair, and 0% poor. In addition, in terms of patient and HCP acceptance of the splint, nine of the ten patients stated that they would use the 3D-printed custom splint again, if needed, in the future. In conclusion, a high level of patient and HCP acceptance signifies the clinical advantage of using 3D-printed splints. This pilot study shows that advances in 3D printing could make custom splinting a viable option for use in personalized healthcare.
Manufacturing and degrading features of 3D-printed porous spinal interbody fusion cages
Authors: Jiao Zhiwei , Chi Pengfei , Zou Hanlin , Yu Yuan , Yang Weimin , Liu Hao , Chen Dong , Zou Haibo
Published: April 2024

Spinal fusion operations are often utilized to address disc degeneration, vertebral slippage, instability, and trauma, and interbody fusion cages have been widely employed in these procedures. The fundamental aim of an interbody fusion cage is to give immediate interbody support, height, and biomechanical stability of the spinal space to enable bone development in the fused area. With the aim to address shortcomings of the currently commonly used clinical spinal interbody fusion cages, such as non-osteogenic activity, non-resorbability, biomechanical mismatch, etc., composites made of polycaprolactone (PCL) were prepared in this study, with the addition of hydroxyapatite (HA) that possesses both osteoinductive properties and enhanced mechanical strength as a functional filler. An innovative bi-directional variable meso-structure scheme is proposed. The porous degradable spinal interbody fusion cage was manufactured by using polymer melt differential three-dimensional (3D) printing technology. The study of the cage’s 3D structural characteristics on the degradation properties and the influence of the degradation process on its mechanical properties was carried out. Preliminary cell viability assays were also conducted. This study showed that the compressive strength of the cages increases with the aperture diameter and the number of crossing layers of the beams, and the compressive modulus is positively associated with the number of crossing layers of the beams. The degradation rate of the cage grew with the reduction of its filling rate and the rise of the number of crossing layers of the beams, i.e., the degradation rate increased with the expansion of the internal aperture. The cage with a 60% internal filling rate and containing 1 or 2 crossing layers of beams is more suited for spinal fusion, and with a pore size between 450 and 490 μm, the fundamental structure of the cage can be preserved while maintaining strong support performance throughout degradation. In addition, the 3D printing process in this study does not cause an increase in cytotoxicity, making it a feasible bioprinting method.
A new solution for in situ monitoring of shape fidelity in extrusion-based bioprinting via thermal imaging
Authors: Giovanni Gugliandolo Simone , Prioglio Egon , Moscatelli Davide , Maria Colosimo Bianca
Published: April 2024

Bioprinting is an interdisciplinary study field, where additive manufacturing is combined with tissue engineering and material sciences. The ever-increasing need for personalized medicine fueled interest in the possibility of using this technique to reproduce biological tissues, allowing bioprinting to establish itself as one of the most promising approach in biomedical research. Producing bioconstructs that resemble living tissues is a very complex and multi-step procedure. Given the complexity of the processes involved, the literature still lacks robust solutions for monitoring the bioprinted construct quality, especially in situ and in-line. Here, a novel non-destructive approach for monitoring the geometries of bioprinted constructs based on infrared (IR) imaging is proposed. Besides the intuitive use of IR information to gain insight on the temperature signature, we propose IR video imaging as a viable solution to overcome traditional problems of visible-range imaging for geometry reconstruction with transparent bioinks, especially when precise information on the last printed layer only is required. The results obtained show a significant new direction for in-line monitoring of bioprinting processes.
Multi-physical field control piezoelectric inkjet bioprinting for 3D tissue-like structure manufacturing
Authors: Zhu Huixuan , Li Run , Li Song , Guo Kai , Ji Chuang , Gao Feiyang , Zheng Yuejing , Zhu Runyang , Wang Heran , Zhang Liming , Liu Lianqing , Zheng Xiongfei
Published: April 2024

 With high precision, drop-on-demand, and noncontact material delivery advantages, inkjet bioprinting technology has been widely used in tissue manufacturing. However, the main challenge of inkjet bioprinting is that the bioink must be liquid-like in the printhead to avoid clogging the nozzle, then form microdroplets, and finally undergo crosslinking to quickly form a gel and make an object with strength and precision. The primary solution relies on the fast crosslinking of sodium alginate by calcium chloride. Nevertheless, it is difficult to guarantee the precision of inkjet bioprinting with this method, and cumulative errors lead to the inability to print high aspect ratio three-dimensional (3D) structures. Additionally, sodium alginate lacks cell adhesion sites, and calcium chloride at high concentrations is toxic to cells. To solve the above problems, we present a new printing method called multi-physical field control piezoelectric inkjet bioprinting (MFCPIB) for making 3D tissue-like structures using 5% gelatin methacryloyl (GelMA). For extrusion and photocuring 3D bioprinting tasks, 5% GelMA is widely used due to its favorable biocompatibility. In this study, we accomplished a 5% GelMA inkjet bioprinting for the first time by leveraging the MFCPIB method. Our experimental results demonstrated the feasibility of this approach for printing GelMA of different concentrations. The temperature-sensitive GelMA was utilized during the printing process in which GelMA is liquid-like in the high-temperature printhead, cools in the form of microdroplets in cold air after injection, and finally photocrosslinks to form a permanent gel. We analyzed the inverse piezoelectric effect and fluid dynamics to control the pressure field, which in turn controls the velocity and diameter of the microdroplets. After conducting a simulation analysis of the temperature field and performing calculations using the lumped parameter method, we implemented a dual closed-loop control strategy to ensure precise temperature control of the microdroplets. Furthermore, based on the analysis of energy conversion, we obtained the pressure and temperature field control laws corresponding to the ideal printable temperature of the microdroplet. Using the MFCPIB method, different 3D structures were successfully printed with GelMA. For example, a cell-laden vessel-like structure with an aspect ratio of 4.0 was achieved. The proposed MFCPIB method did not influence the viability of smooth muscle cells after printing, demonstrating the potential for fabricating tissues with high bioactivity.
Enhancing cell proliferation in three-dimensional hydrogel scaffolds using digital light processing bioprinting technology
Authors: Choi Yejin , Wook Seo Jeong , Jang Goo , Kyung Jung Woo , Ho Park Yong , Bae Hojae
Published: April 2024

Three-dimensional (3D) bioprinting is gradually emerging as a popular technique driving as a new paradigm in tissue engineering. Enhancing cell proliferation and engraftment within volumetric 3D-bioprinted scaffolds is a key challenge in its implementation. However, basic exploratory studies on cell proliferation enhancement in 3D-bioprinted scaffolds using digital light processing (DLP) technology are still lacking. Traditionally, microchannels in scaffolds have been regarded as non-functional, empty spaces. In this paper, however, we propose that microchannels implanted in DLP-bioprinted scaffolds can provide space for cell proliferation, giving a new definition to microchannel function. To this end, we used fish gelatin methacrylate (F-GelMA) as a bioink with photocurable properties, followed by functional evaluation and optimization through rheological analysis. The morphology of DLP-printed scaffolds using the bioink was analyzed, and their biocompatibility was demonstrated through cell viability analysis. Microchannels of three different sizes were implanted to facilitate oxygenation, nutrient delivery, and media flow by addressing structural barriers identified via morphological analysis. Cell viability and proliferation rates in outer and inner microchannels were then comparatively analyzed. During the long-term culture period (about 5 weeks), the differences in proliferation rates due to changes in the media flow environment were assessed. The results demonstrated that cell survival, growth, and proliferation were significantly enhanced within the DLP-printed scaffolds in which the cells were encapsulated. This approach lends itself useful for basic exploratory study utilizing 3D culture technology in the realms of regenerative medicine and tissue engineering, where effective cell proliferation relative to the same volume is required.
 