bluuebunny/crossref_metadata_2025 huggingface dataset:
Profil neuropsychologique et mémoire de travail dans le trouble bipolaire
Authors: Coppola Frédéric , Courtet Philippe , Olié Emilie
Published: November 2017

Selon l’Organisation Mondiale de la Santé (OMS), le trouble bipolaire fait partie des dix maladies les plus couteuses et invalidantes sur le plan mondial. La prise en charge habituelle de cette pathologie comprend un suivi psychiatrique dont la fréquence est adaptée à l’état thymique, et la mise en place d’un traitement thymorégulateur. Toutefois, le devenir des patients atteints de trouble bipolaire reste insatisfaisant. Les répercussions psychosociales, majorées par la présence fréquente de comorbidités somatiques et psychiatriques sont importantes (Bonnin et al., 2010) et peuvent être invalidantes: désinsertion socioprofessionnelle, isolement social, retentissement familial, bas niveau socio-économique, moindre qualité de vie. Une altération fonctionnelle est ainsi retrouvée lors des phases de décompensations aigues, mais également en période intercritique où différents facteurs peuvent être impliqués: symptomatologie résiduelle thymique ou cognitive, comme conséquences des épisodes, présence de comorbidités…En effet, 30% des patients bipolaires présentent pendant cette phase de la maladie des déficits cognitifs, objectivables par des tests neuropsychologiques (Gualtieri and Morgan, 2008). Près de deux tiers présentent des plaintes cognitives subjectives (Martinez-Aran et al., 2005) qui sont négativement corrélées avec la qualité de vie. Parmi ces déficits, l’atteinte de la mémoire de travail est rapportée par plusieurs études (Bora et al., 2009; Robinson et al., 2006), et semble jouer un rôle important dans le handicap fonctionnel. Prendre en charge les troubles cognitifs semble être un enjeu important afin d’améliorer le fonctionnement, la qualité de vie du patient ainsi que la stabilité du trouble. Cependant, les techniques de remédiation cognitive, largement développées pour les patients atteints de schizophrénie, restent limitées dans le trouble bipolaire, malgré l’impact majeur des déficits cognitifs dans ce trouble.

L’objectif de cet article est de faire le point sur le profil neuropsychologique du patient bipolaire en période intercritique, en mettant en avant le rôle prépondérant de la mémoire de travail dans le handicap fonctionnel. Nous discuterons également des avancées thérapeutiques actuelles permettant de prendre en charge ces déficits et améliorer le fonctionnement du patient.
The Learning Performance of Different Knowledge Map Construction Methods and Learning Styles Moderation for Programming Language Learning
Authors: Shaw Ruey-Shiang
Published: November 2017

This study focused on the relationships between knowledge mapping construction methods and learning performance. The different knowledge mapping methods (by experts vs. by self-learners) were assumed to achieve different learning performance levels. The results of this study show that neither different knowledge map construction methods nor learning styles significantly influenced individual learning performance. Either of the knowledge map construction methods applied to the programming language learning and the learning scores are significantly higher than average. Learning style does not moderate knowledge map construction methods on learning scores. However, learning style is a significant moderator of knowledge map construction methods on learning satisfaction. Different knowledge map construction methods should be considered with different learning styles to significantly increase learning satisfaction. The results could be used to design effective programming language learning materials.
On-Task and Off-Task Behavior in the Classroom: A Study on Mathematics Learning With Educational Video Games
Authors: Beserra Vagner , Nussbaum Miguel , Oteo Macarena
Published: November 2017

When performing a task in the classroom, it is essential to place the focus on learning. In the classroom, it is possible to distinguish between time spent by students on-task and off-task. The former is the time in which the student is focused on the learning task; the latter is the remaining time in which they focus on other activities. Understanding the relationship between the two is a concern for teachers, especially for those who teach mathematics and other subjects that are often considered unattractive by students. Given the opportunity afforded by educational video games to motivate and engage math students, an educational drill-and-practice video game was used in this study to practice second-grade arithmetic and study the students' on-task and off-task behavior. We found that when practicing arithmetic using an educational drill-and-practice video game, time on-task decreases during an activity (30 minutes) as well as over the course of the school year (March to December). This study has implications for the length of mathematics classes at schools as well as the need to vary activities during a class.
The Use of Language in Hospice Care and the Impact on Patients and Families
Authors: Gant Valerie
Published: November 2017

This narrative account describes the perspective of family members experience of hospice care.
Caring for Dying Patient and Their Families
Authors: Garrino Lorenza , Contratto Claudia , Massariello Patrizia , Dimonte Valerio
Published: November 2017

Background:

The literature from recent decades persistently suggests that nurses are not adequately trained in caring for the dying. Numerous studies call for enhanced education in end-of-life care.

Objective:

To explore student nurses’ experience of caring for dying persons and their families and how this experience was influenced by their undergraduate education, with a view to improving end-of-life training.

Methods:

Narrative interviews were administered to a purposive sample of 18 undergraduate students at Turin University’s School of Nursing and analyzed following Giorgi’s qualitative phenomenological methodology.

Results:

The students’ accounts featured 4 main themes: emotions and feelings, reactions and coping strategies, growth in personal and professional awareness, and the professional nursing model. Students reporting positive experience of end-of-life care in clinical settings displayed the expected learning outcomes for undergraduate nursing education.

Conclusion:

This study’s strength lies in the fact that it draws on student nurses’ lived experience to assess training in end-of-life care. It confirms the need to invest in targeted end-of-life education and support for nursing students.
Immobilisation of hydroxyapatite-collagen on polydopamine grafted stainless steel 316L: Coating adhesion and in vitro cells evaluation
Authors: Tapsir Zafirah , Jamaludin Farah H , Pingguan-Murphy Belinda , Saidin Syafiqah
Published: November 2017

The utilisation of hydroxyapatite and collagen as bioactive coating materials could enhance cells attachment, proliferation and osseointegration. However, most methods to form crystal hydroxyapatite coating do not allow the incorporation of polymer/organic compound due to production phase of high sintering temperature. In this study, a polydopamine film was used as an intermediate layer to immobilise hydroxyapatite-collagen without the introduction of high sintering temperature. The surface roughness, coating adhesion, bioactivity and osteoblast attachment on the hydroxyapatite-collagen coating were assessed as these properties remains unknown on the polydopamine grafted film. The coating was developed by grafting stainless steel 316L disks with a polydopamine film. Collagen type I fibres were then immobilised on the grafted film, followed by the biomineralisation of hydroxyapatite. The surface roughness and coating adhesion analyses were later performed by using AFM instrument. An Alamar Blue assay was used to determine the cytotoxicity of the coating, while an alkaline phosphatase activity test was conducted to evaluate the osteogenic differentiation of human fetal osteoblasts on the coating. Finally, the morphology of cells attachment on the coating was visualised under FESEM. The highest RMS roughness and coating adhesion were observed on the hydroxyapatite-collagen coating (hydroxyapatite-coll-dopa). The hydroxyapatite-coll-dopa coating was non-toxic to the osteoblast cells with greater cells proliferation, greater level of alkaline phosphate production and more cells attachment. These results indicate that the immobilisation of hydroxyapatite and collagen using an intermediate polydopamine is identical to enhance coating adhesion, osteoblast cells attachment, proliferation and differentiation, and thus could be implemented as a coating material on orthopaedic and dental implants.
Microfluidic system for synthesis of nanofibrous conductive hydrogel and muscle differentiation
Authors: Hosseinzadeh Simzar , Rezayat Sayed Mahdi , Giaseddin Ali , Aliyan Amir , Soleimani Masoud
Published: November 2017

Microscale hydrogels can be synthesized within microfluidic systems and subsequently assembled to make tissues composed of units such as myofibers in muscle tissue. Importantly, the nanofibrous surface of hydrogels is essential for tissue engineering aims due to inducing beneficial cell–surface interactions. In this study, a new microfluidic platform, embedded with a hydrogel, was introduced that allowed for performing multiple non-parallel steps for the synthetic approaches. Satellite cells, isolated from skeletal tissues of 10-day Naval Medical Research Institute-murine were cultured on the prepared hydrogel within the microfluidic system. The normal proliferation of satellite cells occurred after the employment of continuous perfusion cell culture. Interestingly, the positive results of the immuno-staining assay along with the cellular bridge formation between hydrogel fragments confirmed the muscle differentiation of seeded satellite cells. Further on, COMSOl simulations anticipated that the thermodynamic conditions of the microfluidic system during hydrogel synthesis had to be kept steady while a shear stress value of 15 × 10−6 Pa was calculated, exhibiting a cell culture condition free of environmental stress.
The Association Among Parental Bonding, Depression, Social Aggression, and Criminal Assault: Are There Gender Differences Between Male and Female Youth Offenders?
Authors: Tisak John , Tisak Marie S. , Baker Erin R. , Amrhein Kelly E. , Jensen Cjersti
Published: November 2017

This research examined similarities and differences in gender regarding social aggression, criminal assault, depression, and familial factors. The participants were 251 youth offenders (158 males) who were arrested and incarcerated in a juvenile facility. The measures consisted of self-reported acts of social aggression, simple and aggravated assault, subtypes of depression, and self-reports on parental care and control. Our data demonstrate the importance of including gender, types of aggression/assault, subtypes of depression, and familial factors when examining their association. For example, less parental care predicted more social aggression for both males and females. However, neither did parental care predict aggravated assault for either gender, nor did parental care predict general depression or anhedonia. Parental control had different impact depending on gender. More parental control increased rates of social aggression and simple assault for females but not for males. Symptoms of general depression predicted committing simple assault for both males and females, but not anhedonia. However, general depressive symptoms and anhedonia were associated with committing aggravated assault for both genders. Policy implications were discussed.
Healthy Immigrant Families: Randomized Controlled Trial of a Family-Based Nutrition and Physical Activity Intervention
Authors: Wieland Mark L. , Hanza Marcelo M. M. , Weis Jennifer A. , Meiers Sonja J. , Patten Christi A. , Clark Matthew M. , Sloan Jeff A. , Novotny Paul J. , Njeru Jane W. , Abbenyi Adeline , Levine James A. , Goodson Miriam , Capetillo Graciela D. Porraz , Osman Ahmed , Hared Abdullah , Nigon Julie A. , Sia Irene G.
Published: November 2017

Purpose:

To evaluate a healthy eating and physical activity intervention for immigrant families, derived through community-based participatory research.

Design:

The Healthy Immigrant Families study was a randomized controlled trial with delayed intervention control group, with families as the randomization unit.

Setting:

US Midwest city.

Participants:

Participants were recruited by community partners from Hispanic, Somali, and Sudanese immigrant communities.

Intervention:

Family health promoters from participating communities delivered 6 healthy eating modules, 4 physical activity modules, and 2 modules synthesizing information in 12 home visits (60-90 minutes) within the first 6 months. Up to 12 follow-up phone calls to each participant occurred within the second 6 months.

Measures:

Primary measures were dietary quality measured with weekday 24-hour recall and reported as Healthy Eating Index score (0-100) and physical activity measured with accelerometers (14 wear days) at baseline, 6, 12, and 24 months.

Results:

In total, 151 persons (81 adolescents and 70 adults; 44 families) were randomly assigned. At 12 months, significant improvement occurred in Healthy Eating Index scores for adults in the intervention group compared with controls (change, +8.6 vs −4.4; P < .01) and persisted at 24 months (+7.4 from baseline; P < .01). No differences were observed for adolescents and no significant differences occurred between groups for physical activity.

Conclusion:

This intervention produced sustained dietary quality improvement among adults but not among adolescents. Program outcomes are relevant to communities working to decrease cardiovascular risk among immigrant populations.
Positive Aspects of Caregiving and Caregiver Burden: A Study of Caregivers of Patients With Dementia
Authors: Abdollahpour Ibrahim , Nedjat Saharnaz , Salimi Yahya
Published: November 2017

Background:

Now positive aspect of caregiving (PAC) is well-defined as caregiver gains, satisfaction, meaningful life, and enhanced family relationship. The adjusted association of PAC and caregiver burden is not well acknowledged. This study investigated the association of caregiver burden and PAC adjusting for potential confounders.

Methods:

This was a cross-sectional study that recruited 132 caregivers. A linear regression model with PAC was used to estimate the adjusted associations.

Results:

The caregiver burden was negatively associated with PAC (mean difference in PAC per a 1-unit increase in caregiver burden = −0.12, 95% confidence interval: −0.18 to −0.056; P < .001). This association remained after adjustment for caregivers’ age and marital status as well as patients’ dependency level.

Conclusion:

The negative significant association of caregiver burden with PAC reinforces the need for interventional and/or educational programs aiming at decreasing the overall imposed burden. This can play an important role in improving caregivers’ general health and quality of life.
University–industry cooperation and the transition to innovation ecosystems in Japan
Authors: Ranga Marina , Mroczkowski Tomasz , Araiso Tsunehisa
Published: November 2017

This article looks at the evolution of university–industry collaboration (UIC) policies in Japan since the mid-1990s to the present and analyses their role in shaping the country’s innovation ecosystem. UIC policies are examined within a multidimensional innovation policy framework that encompasses five Science and Technology Basic Plans and a vast array of support measures for venture business, intellectual property, innovation networks and business promotion, all reflecting an extensive top-down government intervention with ambitious goals. A dense network of UIC centres has been established throughout the country, mostly in universities, and these centres are tightly embedded in regional innovation structures. In spite of the sustained government policy intervention, Japan lags behind the United States and Europe in a ranking of the top 20 global ecosystems and has some of the world’s lowest entrepreneurial indicators, as defined by the Global Entrepreneurship Monitor. The authors argue that a likely cause for the lag is Japan’s slow and still incomplete transition from a ‘traditional’ innovation system to a modern innovation ecosystem with a strong entrepreneurial spirit and culture, effective intermediaries between university and industry, high absorptive capacity in companies using academic research, cross-boundary mobility of workforce and ideas and global outreach. The experience of Osaka University and Hokkaido University, two UIC leaders in Japan and internationally, supports this hypothesis.
Smooth time-dependent receiver operating characteristic curve estimators
Authors: Martínez-Camblor Pablo , Pardo-Fernández Juan Carlos
Published: November 2017

The receiver operating characteristic curve is a popular graphical method often used to study the diagnostic capacity of continuous (bio)markers. When the considered outcome is a time-dependent variable, two main extensions have been proposed: the cumulative/dynamic receiver operating characteristic curve and the incident/dynamic receiver operating characteristic curve. In both cases, the main problem for developing appropriate estimators is the estimation of the joint distribution of the variables time-to-event and marker. As usual, different approximations lead to different estimators. In this article, the authors explore the use of a bivariate kernel density estimator which accounts for censored observations in the sample and produces smooth estimators of the time-dependent receiver operating characteristic curves. The performance of the resulting cumulative/dynamic and incident/dynamic receiver operating characteristic curves is studied by means of Monte Carlo simulations. Additionally, the influence of the choice of the required smoothing parameters is explored. Finally, two real-applications are considered. An R package is also provided as a complement to this article.
Book Review: Walter Vieira, The Impatient Manager
Authors: Bisht Nidhi S.
Published: November 2017

Walter Vieira, The Impatient Manager, 2016, New Delhi: SAGE Publications, 184 pp., ₹295. ISBN: 978-93-859-8527-0
Identifying free-text features to improve automated classification of structured histopathology reports for feline small intestinal disease
Authors: Awaysheh Abdullah , Wilcke Jeffrey , Elvinger François , Rees Loren , Fan Weiguo , Zimmerman Kurt
Published: November 2017

The histologic evaluation of gastrointestinal (GI) biopsies is the standard for diagnosis of a variety of GI diseases (e.g., inflammatory bowel disease [IBD] and alimentary lymphoma [ALA]). The World Small Animal Veterinary Association (WSAVA) Gastrointestinal International Standardization Group proposed a reporting standard for GI biopsies consisting of a defined set of microscopic features. We compared the machine classification accuracy of free-text microscopic findings with those represented in the WSAVA format with a diagnosis of IBD and ALA. Unstructured free-text duodenal biopsy pathology reports from cats ( n = 60) with a diagnosis of IBD ( n = 20), ALA ( n = 20), or normal ( n = 20) were identified. Biopsy samples from these cases were then scored following the WSAVA guidelines to create a set of structured reports. Three supervised machine-learning algorithms were trained using the structured and then the unstructured reports. Diagnosis classification accuracy for the 3 algorithms was compared using the structured and unstructured reports. Using naive Bayes and neural networks, unstructured information-based models achieved higher diagnostic accuracy (0.90 and 0.88, respectively) compared to the structured information-based models (0.74 and 0.72, respectively). Results suggest that discriminating diagnostic information was lost using current WSAVA microscopic guideline features. Addition of free-text features (number of plasma cells) increased WSAVA auto-classification performance. The methodologies reported in our study represent a way of identifying candidate microscopic features for use in structured histopathology reports.
Attentional Control in Accidents Involving Agricultural Tractor Operators
Authors: Di Nocera Francesco , Ricciardi Orlando , Longo Emiliano , Mastrangelo Simon , Cutini Maurizio , Bisaglia Carlo
Published: November 2017

Feature at a glance: Although a lack of safety features is often reported as the most important factor in tractor accidents, an accident per se is the outcome of many elements, including the amount of attentional control operators exert over the driving task. The lack of active attentional control is sometimes referred as “absentmindedness,” and many studies have investigated this phenomenon as the expression of individual differences. The present retrospective study represents a first attempt at investigating the relation between lack of attention and tractor accidents in a large sample of operators. The results show that attentional control is involved in tractor accidents, which can be taken as evidence of habit effects in operating agricultural machinery: Lower attentional control is required in routine actions, which makes expert operators more exposed to the possibility of making (skill-based) errors. This finding leads to suggestions for the design of future systems.
Design and optimization of the in-wheel motor driving electric vehicle based on the vibration energy transmission
Authors: Tan Di , Song Fan , Wang Qiang
Published: November 2017

In order to solve the problems of the increasing unsprung mass and the influence of the road excitation on the in-wheel motor (IWM), this paper puts forward two kinds of improved topology schemes. The bond graph (BG) and mathematical models of original and improved topological schemes are developed by using the BG theory. Based on the mathematical model, the final topology scheme is determined by the analysis of vibration energy transfer characteristics for the three schemes. It is further proved that the vibration energy analysis method is effective and complete in revealing the change of the system force and motion through the comparison analysis of the three kinds of topology scheme related to vehicle force and ride comfort index of motion variable. Furthermore, the optimal design is carried out for the determined topology scheme, which is aimed at minimum vibration energy delivered to the vehicle body. The comparison results before and after optimization show that: after optimization, the vibration energy delivered to the vehicle body has significantly decreased in the whole frequency range, and the vibration energy delivered to other components also decreased, which proved the correctness of the optimization method; and the comparison results of ride comfort index before and after optimization validate the effectiveness of the parameter optimization design based on the energy method. Finally, a structure design is provided based on the determined topology scheme. This paper provides an idea and method for the vibration suppression of the IWN driving electric vehicle (EV), while it can also provide some theoretical guidance for the design and optimization of the IWN driving EV.
Understanding Trauma Normativeness, Normalization, and Help Seeking in Homeless Mothers
Authors: Brush Barbara L. , Gultekin Laura E. , Dowdell Elizabeth B. , Saint Arnault Denise M. , Satterfield Katherine
Published: November 2017

Although trauma-informed approaches guide services to families experiencing homelessness, more emphasis is placed on securing housing than addressing underlying trauma contributing to housing instability. Examining the stories of 29 homeless and/or unstably housed mothers within the broader literature on family trauma and violence, chronic illness, and cultural aspects of family functioning, we define the process of trauma normativeness and normalization that may occur with repeated trauma experiences and argue that rehousing efforts must include concomitant attention to trauma and to understanding how individual, family, community, and cultural factors influence help-seeking behaviors in this vulnerable and growing population.
Actual versus recommended storage temperatures of oral anticancer medicines at patients’ homes
Authors: Vlieland ND , van den Bemt BJF , van Riet-Nales DA , Bouvy ML , Egberts ACG , Gardarsdottir H
Published: November 2017

Background

Substantial quantities of unused medicines are returned by patients to the pharmacy each year. Redispensing these medicines would reduce medicinal waste and health care costs. However, it is not known if medicines are stored by patients as recommended in the product label. Inadequate storage may negatively affect the medicine and reduce clinical efficacy whilst increasing the risk for side effects.

Objective

To investigate the proportion of patients storing oral anticancer medicines according to the temperature instructions in the product label.

Methods

Consenting adult patients from six Dutch outpatient hospital pharmacies were included in this study if they used an oral anticancer medicine during February 2014 – January 2015. Home storage temperatures were assessed by inclusion of a temperature logger in the original cancer medicines packaging. The primary outcome was the proportion of patients storing oral anticancer medicines as specified in the Summary of Product Characteristics, either by recalculating the observed temperature fluctuations to a single mean kinetic temperature or by following the temperature instructions taking into account a consecutive 24-h tolerance period.

Results

Ninety (81.1%) of the 111 included patients (47.8% female, mean age 65.2 (SD: 11.1)) returned their temperature loggers to the pharmacy. None of the patients stored oral anticancer medicines at a mean kinetic temperature above 25℃, one patient stored a medicine requiring storage below 25℃ longer than 24 h above 25℃. None of the patients using medicines requiring storage below 30℃ kept their medicine above 30℃ for a consecutive period of 24 h or longer.

Conclusion

The majority of patients using oral anticancer medicines store their medicines according to the temperature requirements on the product label claim. Based on our results, most oral anticancer medicines will not be negatively affected by temperature conditions at patients’ homes for a maximum of three months and are likely to be suitable for redispensing.
Hydrothermal grain pre-processing and ultra-fine milling for the production of durum wheat flour fractions with high nutritional value
Authors: Ciccoritti Roberto , Terracciano Giovanna , Cammerata Alessandro , Sgrulletta Daniela , Del Frate Viviana , Gazza Laura , Nocente Francesca
Published: November 2017

This work describes a process for producing durum wheat flour fractions with high potential nutritional value using grain pre-milling hydrothermal treatment and ultra-fine grinding (micronization), coupled with air classification. The difference of bioactive value of the flour fractions in relation to dietary fibre and phenolic compounds was monitored on four durum wheat cultivars by analysing total arabinoxylans, water extractable arabinoxylans and 5- n-alkylresorcinols. The extractability of the analysed compounds was most significantly affected by hydrothermal treatment. On average, the hydrothermally treated kernels compared with the untreated ones presented a marked increase of water extractable arabinoxylans and alkylresorcinols (about 25 and 48%, respectively), whereas slightly lower total arabinoxylans content (about 9%) was detected. The air classification applied on micronized kernels produced two flour fractions, coarse and fine, with the last showing, irrespective of the hydrothermal treatment, an increment of alkylresorcinols (24 and 22% in untreated and treated samples) and of total arabinoxylans (13 and 20% in untreated and treated samples) in comparison with the coarse one. The fine fraction (particles ≤ 120 µm), resulting richer in bioactive compounds, provides an interesting raw material to enrich traditional semolina in which, due to the removal of the external layers, the losses of total arabinoxylans and of alkylresorcinols were more than 60 and 90% alkylresorcinols, respectively, if compared with whole wheat grain.
An Atypical Presentation of Alagille Syndrome
Authors: Wu Katherine Y , Treece Amanda L , Russo Pierre A , Wen Jessica W
Published: November 2017

Alagille syndrome is a multisystem disorder classically involving the liver, heart, vertebrae, facial features, and the eyes. In this case report, we document a case of Alagille syndrome with an atypical clinical and histopathologic presentation and subsequent identification of a novel JAG1 missense mutation. This case highlights that there may be both atypical clinical and pathologic findings in mutation-proven Alagille syndrome and that the diagnosis of Alagille syndrome should be considered in cases of ongoing bile duct damage in the setting of early-onset jaundice, cholestasis, hepatosplenomegaly, posterior embryotoxon in the eyes, and butterfly vertebrae.
Ossifying Renal Tumor of Infancy: Report of a Case With Positive WT1 Immunohistochemistry and High Mitotic Index and Review of the Literature
Authors: Vaillancourt Benoit , Oligny Luc , Déry Julie , Franc-Guimond Julie , Soglio Dorothée Bouron-Dal
Published: November 2017

Ossifying renal tumor of infancy (ORTI) is a rare, benign pediatric tumor of the kidney. Since first reported by Chatten in 1980, 23 cases have been published. Previous authors have argued that ORTI might originate from nephrogenic rests, thereby sharing a pathogenic relationship with Wilms' tumor (WT). ORTI is characterized histologically by a population of polygonal osteoblast-like cells around an osteoid core and densely cellular component of blastemal-like or spindle cells. While the immunohistochemical profile of the cellular components has been reported, to the best of our knowledge, the status of WT1 expression has only been reported once, where it showed negative marking. Mitoses have been described only sporadically in this neoplasm. We report on a case of ORTI with positive WT1 immunohistochemical marking and numerous mitoses. This case highlights a possible pitfall for misdiagnosing ORTI as a WT and provides additional insight into its pathogenesis.
Growth Restriction, Osteopenia, Placental Massive Perivillous Fibrin Deposition With (or Without) Intervillous Histiocytes and Renal Tubular Dysgenesis—An Emerging Complex
Authors: Abdulghani Sahar , Moretti Felipe , Nikkels Peter GJ , Khung-Savatovsky Suonavy , Hurteau-Miller Julie , Grynspan David
Published: November 2017

We describe a case of a pregnancy complicated by early onset asymmetric growth restriction with anhydramnios with termination occurring at 21 weeks. Fetal autopsy showed demineralization of bones and renal tubular dysgenesis. Placental pathology showed features of massive perivillous fibrin deposition and chronic histiocytic intervillositis. We review prior documentation of this association and briefly discuss potential pathogenesis.
Terminal Deoxynucleotidyl Transferase (TdT)-negative Lymphoblastic Leukemia in Pediatric Patients: Incidence and Clinical Significance
Authors: Yasmeen Sayeeda , Rajkumar Anita , Grossman Heather , Szallasi Arpad
Published: November 2017

Pediatric terminal deoxynucleotidyl tranferase (TdT)-negative precursor B- or T-lymphoblastic leukemia/lymphoma (B-LL and T-LL) cases are rare and their prognostic significance remains controversial. We aimed to determine the frequency of TdT-negative B- and T-LL in the community hospital setting. Between 2005 and 2015, 43 pediatric patients were diagnosed with lymphoblastic leukemia at our institution, of which 6 (14%) were characterized as TdT-negative by flow cytometric analysis. Four of these 6 patients had B-LL and the other 2 had T-LL. Two of the 6 TdT-negative patients also had undetectable CD34 expression by flow cytometry (TdT/CD34 double-negatives). Subsequent paraffin immunohistochemistry confirmed the negative CD34 expression in both cases. By contrast, all the 6 patients had weak TdT-like immunoreactivity in their marrow despite the negative flow cytometric analysis. Furthermore, neither TdT/CD34-negative cases showed myc rearrangement by fluorescent in situ hybridization, ruling out Burkitt leukemia as a differential diagnostic consideration. We conclude that TdT-negative pediatric B- and T-LL cases (especially those that are TdT/CD34 double-negative) may pose diagnostic challenge to hematopathologists, and ancillary studies (paraffin immunohistochemistry to detect TdT and fluorescent in situ hybridization to exclude myc rearrangement) may be instrumental in reaching the correct diagnosis.
Numerical simulation of wind characteristics at bridge site considering thermal effects
Authors: Zhang Mingjin , Li Yongle , Wang Bin , Ren Sen
Published: November 2017

In order to study the variation of wind field characteristics under the influence of thermal effects at a bridge site in a deep-cutting gorge with high-altitude and temperature difference, the simulation of natural convection was realized by adding momentum source terms in FLUENT. And the correctness of the simulation results was verified. Then, choosing Dadu River Bridge located at a deep-cutting gorge in western Sichuan as an engineering background, combined with the variation of temperature tested at the bridge site, the numerical simulation of the wind field characteristics at the bridge site was carried out under the influence of the thermal effects. The influences of different thermal factors on the surface wind characteristics of bridge site area were discussed. The wind characteristics at the bridge site under the combined action of different wind velocities and thermal effects were analyzed. As shown in the results, the maximum vertical wind velocity caused by the thermal effects at the height of main girder is 3.0 m/s, and the maximum horizontal wind velocity is 6.4 m/s. When the upcoming wind velocity is greater than 5.0 m/s, the thermal effects have been significantly reduced, and the wind field at the bridge site is mainly influenced by the upcoming wind velocity, wind direction, and local terrain. Under the influence of thermal, the surface temperature distribution at the bridge site is significantly uneven, which are obviously different from the case of not considering the thermal effects.
Labour market regulation as global social policy: The case of nursing labour markets in Oman
Authors: Ennis Crystal A. , Walton-Roberts Margaret
Published: November 2017

This article examines global social policy formation in the area of skilled migration, with a focus on the Gulf Arab region. Across the globe, migration governance presents challenges to multiple levels of authority; its complexity crosses many scales and involves a multitude of actors with diverse interests. Despite this jurisdictional complexity, migration remains one of the most staunchly defended realms of sovereign policy control. Building on global social policy literature, this article examines how ‘domestic’ labour migration policies reflect the entanglement of multiple states’ and agencies’ interests. Such entanglements result in what we characterize as a ‘multiplex system’, where skilled-migration policies are formed within, and shaped by, globalized policy spaces. To illustrate, we examine policies that shape the nursing labour market in Oman during a period when the state aims to transition from dependence on an expatriate to an increasingly nationalized labour force. Engaging a case-study methodology including a survey of migrant healthcare workers, semi-structured interviews and data analysis, we find that nursing labour markets in Oman represent an example of global policy formation due to the interaction of domestic and expatriate labour policies and provisioning systems. The transnational structuring of policy making that emerges reflects a contingent process marked by conflicting outcomes. We contend that Oman’s nursing labour market is an example of new spaces where global social policies emerge from the tension of competing national state and market interests.
The effects of Baduanjin exercise on fatigue and quality of life in patients with heart failure: A randomized controlled trial
Authors: Chen Dai-Mei , Yu Wen-Chung , Hung Huei-Fong , Tsai Jen-Chen , Wu Hsiao-Ying , Chiou Ai-Fu
Published: November 2017

Aims:

The purpose of this study was to examine the effects of Baduanjin exercise on fatigue and quality of life in patients with heart failure.

Methods:

The study was a randomized controlled trial. Participants diagnosed with heart failure were recruited from two large medical centers in northern Taiwan. Participants were randomly assigned to the intervention ( n=39) or control ( n=41) groups. Patients in the intervention group underwent a 12-week Baduanjin exercise program, which included Baduanjin exercise three times per week for 12 weeks at home, a 35-minute Baduanjin exercise demonstration video, a picture-based educational brochure, and a performance record form. The control group received usual care and received no intervention. Fatigue and quality of life were assessed using a structural questionnaire at baseline, four weeks, eight weeks, and 12 weeks after the intervention.

Results:

Participants in the Baduanjin exercise group showed significant improvement in fatigue ( F=5.08, p=0.009) and quality of life ( F=9.11, p=0.001) over time from baseline to week 12 after the intervention. Those in the control group showed significantly worse fatigue ( F=3.46, p=0.033) over time from baseline to week 12 and no significant changes in quality of life ( F=0.70, p=0.518). Compared to the control group, the exercise group demonstrated significantly greater improvement in fatigue and quality of life at four weeks, eight weeks, and 12 weeks.

Conclusions:

This simple traditional exercise is recommended for Taiwanese patients with heart failure in order to improve their fatigue and quality of life.
Fenestrated TEVAR Using a Guidewire Fixator for Anchoring in Aortic Arch Target Vessels
Authors: Kölbel Tilo , Bosaeus Linus , Tsilimparis Nikolaos , Heidemann Franziska , Rohlffs Fiona , Liungman Krister
Published: November 2017

Purpose: To report a new facilitated method for securing target vessel access during single fenestrated and branched thoracic endovascular repair using a guidewire fixator. Technique: The Liungman Guidewire Fixator (LGF) includes a 0.035-inch guidewire that is fitted with a stopper close to the distal end and a self-expanding anchoring element that is freely movable over the guidewire to the point of the stopper. The technique of using a LGF for anchoring in a target vessel is described in a 75-year-old woman with a 53-mm saccular arch aneurysm. She was treated with a fenestrated Zenith stent-graft that had a catheter-preloaded fenestration for the left subclavian artery (LSA) and a scallop for the left common carotid artery. To avoid through-and-through wire and brachial access, the LGF was used to secure the guidewire in the LSA during stent-graft deployment. Conclusion: The use of an LGF for anchoring in the target LSA during fenestrated arch endografting was feasible and safe.
Cult TV Revival: Generational Seriality, Recap Culture, and the “Brand Gap” of Twin Peaks: The Return
Authors: Hills Matt
Published: November 2017

By exploring one case study of a cult TV revival after decades off-air— Twin Peaks: The Return (Showtime, 2017)—this article defines and then focuses on generational seriality. I consider how the gap of twenty-six years between 1990s Twin Peaks and The Return has impacted on its resurrection by reading new Twin Peaks for its representations of aging and loss. I further consider how fantastical connotations of dementia via the figure of Dougie Jones/Dale Cooper (Kyle MacLachlan) generate a “brand gap” between new and old Twin Peaks. Finally, I address how recap culture has shaped The Return’s generational meanings, separating out “good” subscription TV Twin Peaks from its U.S. network TV predecessor and “quality TV” contemporaries. Although recappers have suggested that Twin Peaks: The Return represents the defeat of TV recap culture, The Return remains equally gothic—marked by doppelgängers and others—in its Showtime text and its recaps.
The curious case of India’s Bolar provision
Authors: Rathod Sandeep K.
Published: November 2017

This article looks at certain recent cases pertaining to Bolar exemption and rights of patentees and its interpretation by Indian courts as well as related litigations in Poland and Germany. This article also discusses the Bolar exemption in RCEP.
‘Saying it without saying it’: using poetry as a way to talk about important issues in nursing practice
Authors: Jack Kirsten , Illingworth Sam
Published: November 2017

The aim of this study was to explore the ways in which student nurses use self-authored poems to think about important aspects of nursing practice. Being a nurse can be rewarding in that it affords opportunities to care for and communicate with others. However, it can also yield challenges, and nurses are often faced with practice filled with uncertainty, grief and loss. Our findings suggest that students can use poetry writing to meaningfully explore nursing practice, engage with critical thinking and consider the feelings of others. Of particular note were the ways in which students use metaphor to explore emotional and relational aspects of practice and the technique of self-distancing when describing difficult and angering events. The work has implications for nurse education and practice. Proactively encouraging students to adopt particular ways of expressive writing might be beneficial for student health and wellbeing. Such an approach has the potential to improve quality care provision and support the emotional health of student nurses, which might lead to a reduction in compassion fatigue, stress and attrition.
A brief historical review of poetry’s place in nursing
Authors: Macduff Colin
Published: November 2017

The relationship between nursing and poetry is not necessarily obvious and may often be seen as marginal to mainstream nursing activities. This review paper seeks to examine this relationship by taking primarily an historical perspective, starting from Nightingale and the development of mainstream professional nursing. Through an indicative rather than exhaustive literature review, the ebb and flow of this relationship is traced. This provides both an overview and specific insights into the ways that poetry can manifest within nursing, highlighting some recent developments and the potential for further applications. As such the paper argues that poetry in its various forms should have more central consideration within nursing practice, education and research.
From impostership to mastersness: experiences of a postgraduate student’s transition to higher education reflected through poetry
Authors: Aird Ruth E
Published: November 2017

Mature students returning to education after a long absence often lack confidence, experiencing feelings of inferiority and of being unworthy of a student role in higher education institutions. The aim of this paper is to reflect upon my experience when making the transition from a mature, senior nurse to a student on a Master’s programme. My experience as a student describes this journey, using blogging and the language of poetry to articulate feelings of impostership, creating a canvas of words that draw pictures of a mind struggling to come to terms with new learning. During the learning journey I started to pen a poem, eventually called ‘Education at Sea’, which became the ensign of an academic voyage. Reflecting on this process through the use of Driscoll’s reflective model, I realised that I was experiencing what is called impostership. The conclusion asserts that higher education institutions must create cultures that enable students to openly communicate these experiences, and offer supportive scaffolded strategies to assist with transitions to and through Master’s-level learning. While this paper is directed specifically at Master’s-level learning, the recommendations may also apply to other levels of learning.
Sensor placement determination in system health monitoring process based on dual information risk and uncertainty criteria
Authors: Salehpour-Oskouei Farzin , Pourgol-Mohammad Mohammad
Published: November 2017

Validity of sensor data is a challenge in system monitoring due to stochastic nature of failure occurrence. The quantity and location of sensors affect the system health information, while sensor malfunction causes misleading results about the system condition. Occurred economic losses are irrecoverable expenses in respect to the monitoring system as well as the system failure. In this study, a dual index approach is proposed for the determination of sensor placement scenarios based on two criteria: (1) uncertainty of sensor information and (2) risk of sensor failure. With about variation of environmental factors conditions (e.g. temperature) and their failure threshold characterization, system failure model is developed and analyzed by a proposed efficient Monte Carlo simulation. Statistical variance of sensor information about estimating of system state as the quantitative uncertainty measure of choice in this research is estimated according to the information value that each possible sensor placement scenario provides through sensor information. In the next phase, risk index is determined based on sensor malfunction and corresponding quantifiable losses through both failure costs and maintenance expenditure. All feasible combinations of sensor failures are considered in the risk model. Finally, a combinatorial criterion is determined through information entropy calculation, which considers both indexes proposed above simultaneously. Sensor placement scenarios are comparatively prioritized based on this criterion. Accordingly, the technical directions are provided for suitability of the criteria for prioritizing sensor arrangement in various systems with different reliability-based characteristics. As a case study, determination of sensor placement is demonstrated on a typical steam turbine. According to the low variation of both information uncertainty and risk indexes, it is concluded that the combinatorial index is the proper criterion for sensor placement determination in health monitoring process of the steam turbine.
Reevaluating Moral Disgust: Sensitivity to Many Affective States Predicts Extremity in Many Evaluative Judgments
Authors: Landy Justin F. , Piazza Jared
Published: November 2017

Disgust-sensitive individuals are particularly morally critical. Some theorists take this as evidence that disgust has a uniquely moral form: disgust contributes to moralization even of pathogen-free violations, and disgust’s contribution to moralization is unique from other emotional states. We argue that the relationship between disgust sensitivity (DS) and moral judgment is not special in two respects. First, trait sensitivity to many other affective states, beyond disgust, predicts moral evaluations. Second, DS also predicts nonnormative evaluative judgments. Four studies supported these hypotheses, using multiple measures of DS, and judgments of moral violations (Studies 1 and 4), conventional violations (Study 1), imprudent actions (Study 1), competence (Study 2), and aesthetic evaluations (Study 3). Our findings call into question the usefulness of “moral disgust” as a psychological construct by showing that the relationship between DS and moral condemnation is one instantiation of a more general association between affect and judgment.