bluuebunny/crossref_metadata_2025 huggingface dataset:
Possibilities of oxidative stress correction in ophthalmic practice
Authors:   Novalex LLC, Moscow, Russian Federation, Ternovoy A.V. , Pavlova T.V. ,   N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation, Nisan B.A. ,   Moscow Helmholtz Research Institute of Eye Diseases, Moscow, Russian Federation
Published: January 2023

A total of 238 patients presenting with the diagnosis of myopia or habitually excessive accommodation strain were examined and treated. It was shown that the introduction of antioxidative drugs in the combined treatment of the above disorders normalized the antioxidant properties of blood plasma and improved the blood supply to the eye which as a result increased the positive relative accommodation. The composite antioxidant drugs proved to exhibit the especially high therapeutic efficacy. Given the numerous reports of the successful use of this group of drugs in various ophthalmic pathologies, the great potential of this therapy area makes it expedient to search for new substances with antioxidant activity, as well as the best ways to administer them. Key words: ophthalmic pathology, oxidative stress, antioxidants, irrigation therapy
CRISE PANDÉMIQUE : LA THÉOLOGIE ET LES ÉGLISES SONT-ELLES « EN BONNE SANTÉ » ?
Authors: Sandoz Dutoit Anne
Published: January 2023

Lors de la deuxième journée de Théologie de la santé, qui s’était tenue à l’université de Lausanne en novembre 2017 (TheoSan02_RehumaniserLaMedecine.pdf [unil.ch]), Dimitri Andronicos, co-directeur de Cèdres formation, avait posé la question pertinente de la santé de la théologie de la santé. En cette période marquée par « la Covid-19 », il me semble urgent de reprendre l’interpellation pour l’étendre à la théologie en général et aux Églises : quelle est la santé de la théologie et des Églises pour faire face dans une situation de crise et aider à faire face ?

Dans les bouleversements actuels, je me demande en effet si la théologie et les Églises ne se limitent pas à leur rôle institutionnel, dans ce qu’il signifie en matière d’autorité et de responsabilité spécifiques, de tradition et de force organisationnelle. Face à la nécessité du compromis avec le réel, il s’agit dès lors de viser l’« optimum réalisable » (Ricœur, p.47). Demeurer dans cette seule position revient cependant à oublier la dialectique indispensable avec le pôle, ou le rôle, prophétique.
SUPERVISION (1986/1)
Authors: Brand Paul , Bovon Annegreth , Valotton Claude , Zoss Willy
Published: January 2023

Paul BRAND. Petit aperçu historique sur la genèse de la formation à la supervision en Suisse romande (p. 5)
Annegreth BOVON. Prolégomènes à la supervision pastorale. (p. 5)
Claude VALLOTTON et Willy ZOSS. La supervision pastorale (p. 23)
SYSTEME DE NOS CROYANCES (1991/8)
Authors: Dubied Pierre-Luigi
Published: January 2023

Les deux textes qui suivent n’ont qu’une prétention : apporter un peu de lumière sur le rôle et le fonctionnement de nos convictions.
Le premier soutient l’idée que nos convictions sont organisées en systèmes et que leur pratique quotidienne consiste le plus souvent en un arrangement avec la rigueur logique qu’implique leur interdépendance dans l’abstrait. On aboutira à montrer que la foi chrétienne, dans l’interprétation que j’en donne, joue de ce point de vue un rôle très particulier.
Le second mettra en évidence la spécificité́ de la foi chrétienne sous un angle un peu différent : on y lira que la foi ne se réduit pas aux convictions, même les plus justes, ce qui devrait permettre au chrétien une certaine liberté à l’égard de ses propres croyances.
VARIA (1991/10)
Authors: Grimm Robert , Amsler Samuel , Reymond Bernard
Published: January 2023

Présentation

Institution du mariage et conjugalités vécues — Robert Grimm

Le texte de l’Ancien Testament et la prédication chrétienne, quel rapport ? — Samuel Amsler

Itinéraires de la théologie pratique protestante allemande – Bernard Reymond
FLASHES SUR LE PASTORAT (1992/11)
Authors: Vaucher Myriam , Schwab Emmanuel , Duruz Nicolas , Dubied Pierre-Luigi , Reymond Bernard
Published: January 2023

Présentation

Prêtres et pasteurs face au psychologue : comment se le représentent-ils ? — Myriam Vaucher, Emmanuel Schwab et Nicolas Duruz

Pasteur : le spécifique de la consécration — Pierre-Luigi Dubied

Le pasteur vu par les gens : une image à couches sédimentaires — Bernard Reymond
FORMES ET STRUCTURES (1992/14)
Authors: Sordet Jean-Michel , Stolz Fritz , Reymond Bernard , Bürki Bruno
Published: January 2023

Présentation
Communication pluriforme. La vidéo pour analyser la prédication — Jean-Michel Sordet
Église, groupe, mouvement. Formes futures de la pratique ecclésiale — Fritz Stolz
Congrès international de TP :

Rapport — Bernard Reymond
Commentaires — Bruno Bürki

L’Architecture et l’avenir de l’Église — Bernard Reymond
ECCLÉSIOLOGIE ET ARCHITECTURE (1993/16)
Authors: Nelson G. K. , Schwebel Horst , Reymond Bernard
Published: January 2023

Présentation

Sociologie et architecture religieuse — G. K. Nelson

« Recherchez la prospérité de la ville ». Transformation et utilisation des églises en ville — Horst Schwebel

Ecclésiologie et apologétique architecturale — Bernard Reymond
TISSU SOCIAL ET LIEN ECCLESIAL (1994/19)
Authors: Reymond Bernard , Audinet Jacques , Lacny Christophe , Kayrouz Charbel , Denni Gérard , Grellier Isabelle , Huck Bernard , Srrasser Robert , Auque Hubert , Joncheray Jean , Vangi Si-Vavi Kamabu , Troilo Dominique , Adler Gilbert
Published: January 2023

Lors du Congrès international, œcuménique et francophone de théologie pratique qui s’est tenu à Lausanne en mai 1992, les participants venus de France ont décidé́ de se rencontrer nationalement et à intervalles réguliers, la première de ces rencontres a eu lieu à Strasbourg en mars 1994. Tous les textes du présent cahier en sont issus. On sera d’emblée attentif à leur caractère éminemment interconfessionnel, voire interdénominationnel, puisque leurs auteurs appartiennent aussi bien à des Instituts ou Facultés catholiques qu’à des Facultés protestantes, voire à une Faculté évangélique (Vaux-sur-Seine).

On ne sera que plus sensible à la convergence et à la complémentarité́ de leurs analyses.
PÉDAGOGIE ET DIDACTIQUE DU CATÉCHISME (1994/20)
Authors: Reymond Bernard , Dubied Pierre-Luigi , Baumann Maurice , Wyler Alain
Published: January 2023

Présentation — Bernard Reymond

L’expérience en catéchèse — Pierre-Luigi Dubied

La didactique : respect du message et respect du destinataire — Maurice Baumann

Pédagogie et didactique du catéchisme : une relecture — Alain Wyler
MUSIQUE ET LITURGIE (1995/22)
Authors: Calame Olivier
Published: January 2023

Présentation

Musique et liturgie — Olivier Calame
PERSPECTIVES AMÉRICAINES EN THÉOLOGIE PRATIQUE (1996/24)
Authors: Mullino Moore Mary Elizabeth , Seymour Mudge Lewis
Published: January 2023

Présentation

La théologie pratique aux États-Unis : Une diversité d’options — Mary Elizabeth Mullino Moore

Les théologiens et le débat sur la société civile — Lewis Seymour Mudge
HOMILÉTIQUE, INTERNET ET VIE QUOTIDIENNE (1996/25)
Authors: Reymond Bernard , Black Kathy , Herrmann Jörg , Mertin Andreas , Dubied Pierre-Luigi
Published: January 2023

Présentation — Bernard Reymond

La prédication : une présence au-delà des mots — Kathy Black

Virtuelle religion. Religion et monde virtuel ? — Jörg Herrmann & Andreas Mertin

Pour revenir à la vie quotidienne — Pierre-Luigi Dubied
HISTOIRE ET PRATIQUE DES SERVICES FUNÈBRES (1998/31)
Authors: Reymond Bernard , Musy-Neuhaus Sonja
Published: January 2023

Présentation

Services funèbres : quelques aspects historiques — Sonja Musy-Neuhaus

Remarques de pastorale, de liturgique et d’homilétique funéraires — Bernard Reymond
THÉOLOGIE PRATIQUE ET THÉOLOGIE PASTORALE (1998/32)
Authors: Mottu Henry , Reymond Bernard , Valotton Claude
Published: January 2023

Avant-propos — Henry Mottu

Principes et méthodes de la théologie pratique — Bernard Reymond

Musique et théologie pratique — Bernard Reymond

Musique et architecture religieuse protestante — Bernard Reymond

La théologie peut-elle devenir « pastorale » ? — Claude Vallotton
ENSEIGNEMENT ET RELIGION (2000/36)
Authors: Delessert Sylvette , Gfeller Mariette , Maire Christiane , Pilet Micheline , Paroz Pierre , Chopard Rose-Marie , Schwab Claude , Wicht Herbert , Goumaz Jean-Daniel , Luy Marie-madeleine , Berger François , Gerhard Yvette , Maudry Marlyse , Cattin Thierry , Aeschlimann Maya
Published: January 2023

Qu’est-ce que l’AREC ? — Sylvette DELESSERT

Bref tour d’horizon de la catéchèse dans les Églises réformées de Suisse Romande — Mariette GFELLER, Christiane MAIRE, Micheline PILET, Pierre PAROZ

Une plus grande professionnalisation des catéchètes est-elle nécessaire ou souhaitable ? — Rose-Marie CHOPARD

L’enseignement à l’école et la catéchèse : belle complémentarité ! — Sylvette DELESSERT

Qu’est-ce qu’Enbiro ?

Enseignement de la religion : Entre tradition et défis — Claude SCHWAB

Petit tour de Romandie de l’enseignement religieux — Herbert WICHT, Jean-Daniel GOUMAZ, Marie-Madeleine LUY, François BERGER

Thèses des formateurs romands en « enseignement religieux »

Un exemple de formation d’enseignants — François BERGER

Témoignages d’enseignant-e-s Yvette GERHARD, Marlyse MAUDRY, Thierry CATTIN, Maya AESCHLIMANN
ÉDUCATION PASTORALE CLINIQUE (2001/41)
Authors: Bauer Olivier , Odier Cosette , Von Bremen Konrade , Rojas Jean-Luc
Published: January 2023

Avant-propos — Olivier BAUER

Les stages en milieu hospitalier : une méthode spécifique de formation à la relation pastorale — Cosette ODIER

La formation pastorale : regard d’un médecin — Konrade von BREMEN

Impressions d’un pasteur stagiaire — Jean-Luc ROJAS
CULTE PROTESTANT (2001/2)
Authors: Bauer Olivier , Mottu Henry
Published: January 2023

Notre Institut Romand de Pastorale vient d’organiser à Crêt-Bérard, du 16 au 18 juin 2000, un colloque intitulé États généraux du culte protestant. Cet intitulé, quelque peu ambitieux, ne doit pas conduire les lecteurs et lectrices à croire qu’il s’agirait ici d’un aboutissement définitif. Nous voulions plutôt faire le point ensemble, nous arrêter sur les expériences présentes menées ici et là en Suisse romande, réfléchir sereinement à l’avenir du culte. Je regrette que la presse n’ait retenu que le mot « crise » et beaucoup moins celui de reconstruction, qui nous tenait à cœur ! Foin de la sinistrose et bravo aux nombreuses initiatrices et aux nombreux initiateurs d’essais de renouvellement, beaucoup plus nombreux qu’on ne l’imagine ! À cet égard, je pense avec le recul que l’on se réjouira surtout de lire — pour s’en inspirer, espérons-le — les présentations d’expériences concrètes. Elles furent les moments forts de cette réunion. Notre ministère d’enseignement consiste pour une bonne part à encourager et faire connaître plus largement des initiatives neuves et prometteuses, qui souvent s’inscrivent déjà̀ dans la durée. Dommage que nous n’ayons peut-être pas pu ou pas su évaluer ensemble, universitaires et pasteur(e)s, de tels essais, ce qui était mon objectif initial. Je n’oublie pas les contributions des matinées, fort suggestives et parfois provocatrices.

Pour retrouver la dynamique même du colloque, nous avons retenu la plupart des contributions comme elles ont été exposées, dans l’ordre chronologique prévu, la plupart sous la forme où elles ont été présentées. Je signale seulement que les phrases encadrées ont été choisies par la rédaction. Certaines interventions, notamment des réactions de laïcs qui nous sont parvenues avant ou après le colloque ont été intercalées. Des dessins agrémentent la lecture, l’humour faisant partie de notre religion — quoi qu’on en dise…
NOUVEAUX (?) RITES POUR NOUVEAUX (?) COUPLES (2002/44)
Authors: Vonaesch Pierre , Grimm Robert , Mischler Pierre-Alain , Sandoz Suzette , Manoel Marcel , Heubi Roland , Bassin Raymond , Grinling John
Published: January 2023

Avant-propos Pierre VONAESCH

Un rite « chrétien » de bénédiction nuptiale ? — Robert GRIMM

Extraits de liturgies de mariage — Pierre-Alain MISCHLER

Le partenariat enregistré : faut-il créer une institution nouvelle pour les couples de même sexe ? — Suzette SANDOZ

État de la question dans quelques Églises :

Église réformée de France — Marcel MANOEL

Église réformée évangélique de Neuchâtel — Roland HEUBI

Églises réformées Berne-Jura — Raymond BASSIN

Église protestante de Genève — John GRINLING
ÉGLISES AU RISQUE DE LA VISIBILITÉ (2002/3)
Authors: Bauer Olivier , Moser Félix
Published: January 2023

« C’est la gloire de Dieu de cacher une chose, et la gloire des rois d’agir après examen. »

Proverbes 25,2

En guise de remerciements — et en lien avec le thème de cette brochure —, je choisis de mettre en exergue cette pensée, tirée de l’antique sagesse biblique. Dieu agit parmi nous dans la discrétion. Nous sommes appelés à découvrir sa présence aussi dans les gestes les plus quotidiens de celles et ceux que nous côtoyons.

J’aimerais remercier particulièrement les collègues qui ont pris le temps de participer à ces deux semaines d’études. Certains ont accepté de livrer dans la sphère publique les textes de leur contribution ; si nous les avons réunis, chacun reste responsable de ses propos.

Sans l’aide aussi efficace que discrète d’Olivier Bauer (Dr Théol. et assistant à l’Institut Romand de Pastorale), la parution de ces actes du 3e cycle de théologie pratique des Facultés de théologie de Suisse romande 2001 n’aurait pas pu voir le jour dans des délais raisonnables. Ma gratitude va également à Mme Annick Kocher (lic. théol.) qui a relu ces textes et qui s’est attelée au travail aride de compléter et d’harmoniser les notes de pieds de page, lorsque cela était possible.

Reste alors la 2e partie du verset des Proverbes. Je prends la liberté́, dans cette préface, de le transformer : la gloire des lecteurs et des lectrices est d’agir après examen.

Puisse cette publication vous donner l’occasion de visiter de façon inédite, le vaste chantier de l’ecclésiologie, et surtout qu’elle vous donne envie alors d’interpréter, d’identifier, de déchiffrer et de produire des signes de l’amour de Dieu.
SE DÉPLACER POUR ÊTRE DÉPLACÉ·E (2003/46)
Authors: Mottu Henry , Demissy Claude , Auque Hubert
Published: January 2023

Avant-propos — Henry MOTTU

Le retour des liturgies ambulatoires — Claude DEMISSY

Le bibliodrame — Hubert AUQUE
LA CURE D’ÂME FACE AUX NOUVELLES APPROCHES D’ACCOMPAGNEMENT (2004/48)
Authors: Mottu Henry , Valazza Gaetanne , Kocher Annick , Schmid Muriel , Dubied Pierre-Luigi
Published: January 2023

Avant-propos — Henry MOTTU

Coaching et pratique philosophique : une concurrence pour la cure d’âme ? — Gaetane VALAZZA

Une « philosophie concrète » : Gabriel Marcel — Annick KOCHER

Les formations de spiritual direction : une voie pour repenser l’accompagnement pastoral ? — Muriel SCHMID

Cure d’âme en confrontation — Pierre-Luigi DUBIED

Maladie spirituelle et récit de soi — Pierre-Luigi DUBIED
VIVRE LA PROXIMITÉ (2004/49)
Authors: Moser Félix , Mottu Henry , Kocher Annick , Maridor Steve
Published: January 2023

Avant-propos – Félix MOSER

Le Dieu proche et le Dieu des lointains. Un itinéraire théologique – Henry MOTTU

Le service funèbre comme engagement éthique – Félix MOSER

Recensions

Appel à témoins. Mutations sociales et avenir de la mission chrétienne – Annick KOCHER

Précis de théologie pratique – Steve MARIDOR
PRAXÉOLOGIE THÉOLOGIQUE - 2020
Authors: Bauer Olivier
Published: January 2023

La praxéologie théologique est une méthode qui permet d’analyser théologiquement des pratiques, c’est-à-dire des activités publiques, complexes, d’une certaine durée, impliquant des relations, régies par des règles et visant des résultats concrets. Elle est une méthode empirico-herméneutique, où l’on commence toujours par la pratique.

Principes: « Tais-toi ! Observe ! Tu parleras après. » « Pourquoi est-ce que je fais ce que je fais ? »

Sept étapes

Identifier ses préjugés, ses a priori, ses représentations de la pratique.

Observer une pratique théologique : établir qui fait quoi pourquoi quand où comment et pour combien ?

En analyser les valeurs : identifier les valeurs sous-jacentes à la pratique.

La problématiser : choisir un problème, un germe ou un défi que vous jugez majeur dans la pratique.

L’interpréter : établir une norme pour en juger la fidélité (théologie, spiritualité, éthique, philosophie) ; comprendre le contexte pour en augmenter l’efficacité (sciences, sciences des religions, sciences humaines et sociales).

Planifier une intervention : faire des choix responsables et praticables.

Imaginer les conséquences de ses choix : dégager les effets à moyen et long termes.
QUEL CULTE POUR NOS CORPS ? - 2021
Authors: Bauer Olivier
Published: January 2023

Plutôt que de répondre à la question : « Le culte : quelle place pour le corps ? ». Théologiquement, j’aurais tendance à regretter qu’il ne sollicite que des cerveaux entre deux oreilles. Anthropologiquement, je constate que ce sont des corps qui participent au culte. Car le culte, qu’on le veuille ou non, engage toujours, forcément l’être tout entier. Par volonté ou par accident, il donne toujours à entendre, à voir, à toucher, à sentir, à éprouver, parfois ou souvent à goûter. Et même s’il ne le faisait pas, il ne me rendrait pas insensible pour autant. Car si je peux cesser de goûter, j’entends, je vois, je sens, je touche et j’éprouve ce que le culte et le lieu de culte me font éprouver. Consciemment et inconsciemment, je perçois des stimuli sensoriels : un bruit de fond, la chaleur de l’été, la dureté du banc ou le parfum de ma voisine. Le sachant, je crois préférable de solliciter délibérément autant de sens qu’il est possible, autant de sens qu’il est utile.

J’ai donc éprouvé le besoin d’inverser la question et de me demander : « Quel culte pour nos corps ? ». Ce n’est pas seulement, une marque d’indépendance ou la coquetterie d’un auteur, mais la volonté de marquer d’emblée que l’enjeu fondamental me paraît être d’adapter le culte protestant à l’être humain tel qu’il est. Je n’ai guère de mérite, puisque je peux m’appuyer sur quelques autorités, dont Martin Luther, ce qui n’est pas rien.
THE INFLUENCE OF PEER TUTORING-BASED HUMANISTIC MATHEMATICS LEARNING ON THE MOTIVATION OF LEARNING MATHEMATICS OF HIGH SCHOOL STUDENTS
Authors: Noperta Noperta , Sari Maila
Published: January 2023

Many students are not comfortable studying mathematics and think mathematics is a boring subject. So students do not have good motivation in learning mathematics. This is due to the inhumane teaching of mathematics. This research was conducted to assess students' motivation when learning humanistic mathematics based on peer tutors. This research is experimental research with a one group pretest-posttest design. Data were collected using the Attention, Relevance, Confidence, Satisfaction (ARCS) motivation questionnaire. The data were analyzed using the Wilcoxon test because the data obtained were not normally distributed. The results obtained that the value of sig. (2-tailed) of 0.000 is smaller than 0.05 (0.000 < 0.05), which means that the hypothesis is accepted. So that there is a significant comparison between students' mathematics learning motivation before and after applying humanistic mathematics learning based on peer tutors or there is a significant influence between peer tutor-based humanistic mathematics learning on students' mathematics learning motivation.
BIBLIOMETRIC ANALYSIS OF MATHEMATICAL COMMUNICATION SKILLS USING SCOPUS DATABASE
Authors: Yani Nur Fitri , Soebagyo Joko
Published: January 2023

The purpose of this study is to analyze how the development of research publication trends in mathematical communication skills in mathematics learning for the 2016-2021 period published in Scopus indexed scientific journals, review citation analysis, and examine trend analysis of terms or keywords by authors in journals and journals. The sample uses 142 article titles. Bibliometric analysis methods through quantitative studies are used to collect, process, and analyze data related to mathematical communication skills in mathematics learning. Data retrieval using PoP (Publish or Perish) software. Data analysis is descriptive quantitative. The results showed that the trend of scientific publications regarding the trend of mathematical communication skills increased from 2016-2021. It can be seen from the data that the number of articles published during 2019-2020 was the most researched on mathematical communication skills. The most cited articles related to mathematical communication skills occurred in 2019 with 97 citations. The Pisa question, communication technology, prospective mathematics teacher and self-efficacy are variables that are still rarely studied.
THE EFFECT OF THE GUIDED INMETA-ANALYSIS STUDY OF THE EFFECT OF GUIDED INQUIRY MODEL ON CRITICAL THINKING SKILLS OF STUDENTS SCIENCE CONCEPTS
Authors: Sari Nurmala , Istiyono Edi , Purbani Widyastuti , Retnawati Heri
Published: January 2023

The development of education in the 21st century requires educators and students to be able to improve critical thinking skills. The process of improving critical thinking skills requires a learning model, one of which is through a guided inquiry model. The application of the inquiry model is able to train students to have the ability to think about something new so that they can solve students' own concepts or ideas. The purpose of this study was to analyze the effect of the guided inquiry model on students' critical thinking skills. Data collection techniques were carried out by browsing various articles related to the inquiry model and critical thinking skills through Google, Google Scholar, and Scopus. The search results obtained 35 articles or related journals. Data analysis technique was carried out in a quantitative descriptive manner using the help of Microsoft Excel and JASP applications. The results showed that the results of the analysis using the random effect had a significant positive effect or correlation between the guided inquiry model on students' critical thinking skills in science lessons. The results of the egger test and fail safe N analysis show that there is no publication bias in the meta-analytical studies discussed, so that the analyzed meta-analytical studies can be scientifically justified.
THE CONTRIBUTION OF TOULMIN'S ARGUMENTATION PATTERNS IN PHYSICS LEARNING IN INDONESIA: LITERATURE REVIEW
Authors: Amiruddin Mohd Zaidi Bin , Sari Eka Putri Dian Nata , Paramita Uci Vebia , Suliyanah Suliyanah , Admoko Setyo
Published: January 2023

This research is a descriptive research using literature study method which aims to analyze how far is the contribution of Toulmin's Argument Pattern (TAP) in learning physics in Indonesia. The data collection technique used is a review of articles from previous studies related to the application of Toulmin's argument in learning physics. Sources of data used four articles in this research is secondary data. The data obtained were then analyzed using the, organize method, namely organizing the articles to be reviewed, synthesize, which combines the results of organizing articles into an integrated literature,  Identify, which is to identify articles to draw conclusions. Based on the results of the research, it is known that the application of Toulmin's Argumentation in learning Physics in Indonesia has many contributions such as in mastering concepts, problem solving abilities, and especially in improving students' argumentation skills. It is also known that the application of the argumentation-based learning model should be collaborated with problem-based learning models and discussion methods to train students' argument structure preparation. So, for build good argumentation skills, directed teaching is needed by utilizing Toulmin's argumentation pattern.
THE CHARACTERISTICS AND DEVELOPING AN ASSESSMENT INSTRUMENT OF HIGH ORDER THINKING SKILL (HOTS) ITEMS WITH 4-D MODELS
Authors: Mahmudati Rina
Published: January 2023

The 21st century learning aims to develop and improve the process of high order thinking in students, including when solving mathematical problems. This research will discuss the characteristics and developing an assessment instrument of HOTS (high order thinking skill) items. The method used is research and development method with 4-D models (define, design, develop, disseminate). Scoring in Politomus scale was used and analyzed by Partial Credit Model 1 Parameter Logit (PCM 1-PL). Results of the research is 20 test items there are 17 items that qualify as a good items views of validity and reliability. Results based the criteria of Infit Mean Square is 1.00 and a standard deviation of 0.17 indicates test items fit with Partial Credit Model (PCM). Reliability items indicated by Cronbach's Alpha coefficient was 0.79 with the very reliable category. Test items validity based on the empirical analysis showed there are 17 valid test items with 12 test items as good categorized 5 test items as good enough category.
Montelukast Performs Synergistic Effect with Carfilzomib in Multiple Myeloma by Inhibiting the Deubiquitinase UCHL1
Authors:   Zhabei Central Hospital, Jing’an District, Shanghai, China, W Yu , W Wei ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, R Peng ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, H Chen ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, N Zhou ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, L Wu ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, H Shi ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, X Chen ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, D Wang ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, J Wei ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, W Zhao ,   Zhabei Central Hospital, Jing’an District, Shanghai, China, F Zhou ,   Zhabei Central Hospital, Jing’an District, Shanghai, China
Published: January 2023

Immunomodulators play an important role in combination chemotherapy of multiple myeloma. Besides, it has been reported that leukotriene-D4 receptors play an important role in carcinogenesis. The current study was carried out to assess the possible antitumor effects of montelukast (both an immunomodulator and a CysLT1R antagonist) both in single and in combination with carfilzomib in multiple myeloma cells and the potential mechanisms. We performed our experiment using cell apoptosis assay, cell cycle assay, western blot analysis, mitochondrial transmembrane potential, and chemical proteomics based on protein activity. The results showed that montelukast inhibits cell proliferation and leads to cell apoptosis in multiple myeloma cell lines. Then we performed combination of montelukast and carfilzomib on multiple myeloma cells to explore whether they are synergistic. We demonstrated that the combination treatment leads to stronger effect of cell apoptosis. Furthermore, we demonstrated the combination effect is performed independent of the leukotriene-D4 receptors inhibition. Given that protesome inhibitor leads to accumulation of ubiquitin by inhibiting the degradation of these proteins, we tested ubiquitin levels of different groups. We found that montelukast induces ubiquitin accumulation by inhibiting Ubiquitin-Specific Protease UCHL1. All of these lead to the activity of indoplasmic reticulum stress and therefore result in cell apoptosis. This brings us a new idea in the treatment of multiple myeloma. Since montelukast is cheap and widely used in clinic, if it is proved to be effective in the treatment of multiple myeloma, it will greatly reduce the economic pressure of patients and bring new hope to patients.
Untangling the Intertwined: Metallic to Semiconducting Phase Transition of Colloidal MoS2 Nanoplatelets and Nanosheets
Authors: Niebur André , Söll Aljoscha , Haizmann Philipp , Strolka Onno , Rudolph Dominik , Tran Kevin , Renz Franz , Frauendorf André Philipp , Hübner Jens , Peisert Heiko , Scheele Marcus , Lauth Jannika
Published: January 2023

2D semiconducting transition metal dichalcogenides (TMDCs) are highly promising materials for future spin- and valleytronic applications and exhibit an ultrafast response to external (optical) stimuli which is essential for optoelectronics. Colloidal nanochemistry on the other hand is an emerging alternative for the synthesis of 2D TMDC nanosheet (NS) ensembles, allowing for the control of the reaction via tunable precursor and ligand chemistry. Up to now, wet-chemical colloidal syntheses yielded intertwined/agglomerated NSs with a large lateral size. Here, we show a synthesis method for 2D mono- and bilayer MoS2 nanoplatelets with a particularly small lateral size (NPLs, 7.4 nm ± 2.2 nm) and MoS2 NSs (22 nm ± 9 nm) as a reference by adjusting the molybdenum precursor concentration in the reaction. We find that in colloidal 2D MoS2 syntheses initially a mixture of the stable semiconducting and the metastable metallic crystal phase is formed. 2D MoS2 NPLs and NSs then both undergo a full transformation to the semiconducting crystal phase by the end of the reaction, which we quantify by X-ray photoelectron spectroscopy. Phase pure semiconducting MoS2 NPLs with a lateral size approaching the MoS2 exciton Bohr radius exhibit strong additional lateral confinement, leading to a drastically shortened decay of the B exciton which is characterized by ultrafast transient absorption spectroscopy. Our findings represent an important step for utilizing colloidal TMDCs, for example small MoS2 NPLs represent an excellent starting point for the growth of heterostructures for future colloidal photonics.
Unveiling the Mechanical and Electrochemical Evolution of Nano Silicon Composite Anodes in Sulfide based All-solid-state Batteries
Authors: Cao Daxian , Ji Tongtai , Singh Avtar , Bak Seongmin , Du Yonghua , Xiao Xianghui , Xu Hongyi , Zhu Juner , Zhu Hongli
Published: January 2023

The utilization of silicon (Si) anodes in all-solid-state lithium batteries (ASLBs) provides the potential for high energy density. However, the compatibility of sulfide solid-state electrolytes (SEs) with Si and carbon is often questioned due to potential decomposition. To investigate this, operando X-ray absorption near-edge structure (XANES) spectroscopy, ex-situ scanning electron microscopy (SEM) and ex-situ X-ray nano-tomography (XnT) were utilized to study the chemistry and structure evolution of nano Si composite anodes. Results from XANES demonstrated a partial decomposition of SEs during the first lithiation stage, which was further accelerated by the presence of carbon. But the performance of first three cycles in Si-SE-C was stable, which proved the generated media is ionically conductive. XnT and SEM results showed that the addition of SEs and carbon improved the structural stability of the anode with fewer pores and voids. A chemo-elasto-plastic model revealed that SEs and carbon buffered the volume expansion of Si, thus enhancing mechanical stability. The balance between the pros and cons of SEs and carbon in enhancing reaction kinetics and structural stability enabled the Si composite anode to demonstrate the highest Si utilization with higher specific capacities and better rate than pure Si and Si composite anodes with only SEs.
Epik: pKa and Protonation State Prediction through Machine Learning
Authors: Johnston Ryne C. , Yao Kun , Kaplan Zachary , Chelliah Monica , Leswing Karl , Seekins Sean , Watts Shawn , Calkins David , Chief Elk Jackson , Jerome Steven V. , Repasky Matthew P. , Shelley John C.
Published: January 2023

Epik version 7 is a software program that uses machine learning for predicting the pKa values and protonation state distribution of complex, drug-like molecules. Using an ensemble of atomic graph convolutional neural networks (GCNNs) trained on over 42,000 pKa values across broad chemical space from both experimental and computed origins, the model predicts pKa values with 0.42 and 0.72 log unit median absolute and RMS errors, respectively, across seven test sets. Epik version 7 also generates protonation states and recovers 95% of the most populated protonation states compared to previous versions. Requiring on average only 47 ms per ligand, Epik version 7 is rapid and accurate enough to evaluate protonation states for crucial molecules and prepare ultra-large libraries of compounds to explore vast regions of chemical space. The simplicity of and time required for the training allows for the generation of highly accurate models customized to a program’s specific chemistry.
A fluorescent molecular probe for live-cell imaging of starch granules
Authors: Kusano Shuhei , Nakamura Sakuya , Izumi Masanori , Hagihara Shinya
Published: January 2023

Plants accumulate photosynthetic product as starch, which is also a major carbohydrate source for human. Herein, we report the development of a fluorescent molecular probe for starch. Through a in vivo screening-based approach, we identified fluorescein-5-methy thiocarbamate as a candidate of starch probe that works in living plants. We synthesized 19 derivatives for the structural optimization of the starch probe and discovered that fluorescein-5-tert-butyl carbamate is the most specific probe with the brightest fluorescence among them. Analysis using Arabidopsis thaliana mutants of starch metabolism and in vitro NMR experiments revealed that the probe forms a complex with starch and illuminates starch granules in leaf chloroplasts and root amyloplasts within 10 minutes after the probe infiltration into living plant tissues. The starch probe is applicable to track the changes in intracellular starch contents in response to circadian cycle or light conditions. We concluded that fluorescein-5-tert-butyl carbamate can be used as a probe for live-cell and quantitative imaging of starch granules. The probe could be a useful imaging tool to facilitate finding novel phenomena linked with starch metabolism in crop plants.
Novel aqueous flow battery using CO2 redox with a bifunctional homogeneous Ir catalyst
Authors: Kanega Ryoichi , Ishida Erika , Sakai Toshiaki , Onishi Naoya , Yamamoto Akira , Yasumura Hiroki , Yoshida Hisao , Kawanami Hajime , Himeda Yuichiro , Sato Yukari , Ohira Akihiro
Published: January 2023

To suppress CO2 emissions, technologies that incorporate CO2 capture, utilization, and storage are being actively developed. Particularly, batteries using CO2 redox reactions are one of the most promising systems that combine energy conversion and storage. However, the stoichiometric reactions of CO2 and metal restrict the CO2 storage capacity of previously proposed systems. Applying catalyst-mediated CO2 redox is expected to provide flexible control of the CO2 storage capacity without dependence on the metal content. Herein, we report novel aqueous flow battery using CO2–formate redox with a bifunctional homogeneous Ir catalyst. Using of an Ir catalyst bearing a 4-hydroxy-N-methylpicolinamidate ligand was demonstrated for 50 cycles, with a maximum discharge capacity of 1.5 Ah L-1, capacity decay of 0.20% cycle-1, and total turnover number of 3,500. Furthermore, as the design concept, the CO2 storage capacity of the catalyst-based flow battery was improved more than 1000 times compared to the previously proposed system.
Macroeconomic Effects of Foreign Aids on Poverty Level in Nigeria
Authors: Ajisafe R. A.
Published: January 2023

This study examines the effect of foreign aids on poverty level in Nigeria using Autoregressive Distributed Lag (ARDL) approach. Data spanned from 1980-2015 were sourced from World Bank development indicators, Central Bank of Nigeria Statistical Bulletin and National Bureau of Statistics. From the ARDL Bound test approach to co-integration, the result of the study showed that foreign aids help in reducing poverty, but does not have a significant effect on the level of poverty in Nigeria. The study therefore argued that foreign aids could be effective in Nigeria if multilateral and multidimensional aids system were adopted which should be directed to different areas in the Nigerian economy. Also, proper care and monitoring needs to be put in place in order to checkmate any attempt for corruption especially in a situation where private individuals would divert foreign aids to solve private needs.
Geoecological Assessment of Phytoremediation Features When Using Fallopia Sachalinensis in Conditions of Anthropogenic Heavy Metal Pollution of Soils of the Bashkir Trans-Urals
Authors:   Bashkir State University, Elizareva E. N. , Fakhertdinova A. A. ,   Bashkir State University, Elizaryev A. N. ,   Ufa State Aviation Technical University,   Water Problems Institute RAS, Tarakanov D. A. ,   Ufa State Aviation Technical University, Kudashkina N. V. ,   Bashkir State Medical University
Published: January 2023

The relevance of this work is related to solving the problem of soil pollution with heavy metals by applying Fallopia Sachalinensis and obtaining benefits in the recovery process. The aim of the work is to develop an algorithm for geoecological assessment of phytoremediation features when using plants, taking into account the conditions of anthropogenic soil pollution with heavy metals, as well as physiological characteristics and species-specific reactions under abiotic and biotic stress. For the quantitative determination of flavonoids in Fallopia Sachalinensis, a spectrophotometric method was used in the work on a Shimadzu – UV 1800 instrument using a complexing additive – 5% aluminum chloride solution, to determine the content of tannins, the redox titration method was used, in order to detect amino acids, qualitative reactions were carried out with aqueous extraction for three copies of each sample. Quantitative determination of amino acids in the studied samples is carried out on the AAA-339 amino acid analyzer (Czechoslovakia). Approbation of the algorithm on Fallopia Sachalinensis under conditions of anthropogenic contamination of soils of the Bashkir Trans-Urals with heavy metals showed that the plant has an indicator potential, but excludes the production of natural biologically active substances from biomass. At the same time, Fallopia Sachalinensis is resistant to soil pollution with heavy metals and has an increased resistance to industrial pollution, and the possibility of using it as an indicator of soil pollution has also been determined
Chemical Composition of the Snow Cover and Meltwater of the Garmo Glacier Components of the Hydrochemistry of the Obikhingou River in the Vakhsh River Basin
Authors:   Tajik National University, Normatov I. Sh. , Sheralizoda N. Sh. ,   Agency for Hydrometeorology of the Committee for Environmental Protection under the Government of the Republic of Tajikistan, Homidov A. Sh. ,   Agency for Hydrometeorology of the Committee for Environmental Protection under the Government of the Republic of Tajikistan, Sharofzoda F. A. ,   Tajik National University, Muminov A. O. ,   Tajik National University
Published: January 2023

t. The aim of the work is to study the chemical composition of snow cover and meltwater from the Garmo glacier and their contribution to the formation of the hydrochemistry of the Obikhingou river. The results of monitoring the meteorological conditions of the Obikhingou river basin and hydrology for the period 1960-2020 are presented. According to the estimates, the rate of increase in the average annual temperature values for the period 1960-2020 in the Vakhsh river basin as a whole flows differently and is in the basins of its tributaries: Surkhob 6.3∙10-3 оC/yr, Kyzylsu 13.5∙10-3 oC/yr and Obikhingou 18.6∙10-3 oC/yr. The temperature increases on the Vakhsh River upstream by 2050 is expected 0.4-0.7 o C compared to the period 1960-2020. For the period 1960-2020 there was a slight increase amount of atmospheric precipitation in the Obikhingou river basin with an average annual value of 3.7 mm/yr. By determining the concentration of chemical elements on the Obikhingou river downstream, the values of indicators (SAR, %Na+, SSP and ESP) of the applicability of river water for irrigation were calculated that were significantly lower than their critical values.
Analisis Timbal (PB) Pada Rambut Masyarakat Pulau Pasaran Kecamatan Teluk Betung Barat Bandar Lampung
Authors: Nuraini Sri , Ujiani Sri
Published: January 2023

Logam berat merupakan salah satu unsur pencemar perairan yang bersifat toksik dan harus diwaspadai keberadaanya. Logam berat yang masuk ke dalam perairan akan mencemari laut. Selain mencemari air, logam berat juga akan mengendap di dasar perairan yang mempunyai waktu tinggal (residence time) sampai ribuan tahun dan logam berat akan terakumulasi ke dalam tubuh makhluk hidup dengan proses bioakumulasi dan biomagnifikasi dengan beberapa jalan yaitu melalui saluran pernafasan, saluran makanan dan melalui kulit. Bioindikator pencemaran di perairan yaitu dengan. Populasi dalam penelitian ini adalah seluruh masyarakat yang tinggal di Pulau Pasaran Teluk Betung Lampung sampel diambil sebanyak 20 responden  Analisa data yang digunakan pada penelitian ini adalah analisa Univariate. Hasil penelitian didapatkan 90% responden terpapar logam timbal di atas toleransi WHO yaitu sebesar <12 µg/g. kadar terendah sebesar 11.49 µg/g dan kadar teringgi sebesar 200.73 µg/g
Functional papaya beverage increases healthy gut microbiota in Streptozotocininduced diabetic Sprague Dawley rats
Authors: Koh S.P. , Sew Y.S. , Sharifudin S.A. , A. Nur Diyana , Maarof S. , Abdullah R.
Published: January 2023

Diabetes mellitus is a silent killer illness, characterized by hyperglycaemia effect and can
cause many health complications. A new functional papaya beverage was produced via
selected pure symbiotic culture of bacteria and yeast (SCOBY) which offers an alternative
food therapy in regulating blood glucose and its efficacy was evaluated using
Streptozotocin (STZ)-induced diabetic Sprague Dawley rats for one month treatment.
Under moderate diabetes condition, SCOBY papaya beverage was shown able to reduce
high blood glucose in diabetic rats to normal level, comparably effective with commercial
drug, Metformin. Not only that, it also helped restore body weight of diabetic rats to a
healthier state with a gradual increment of body weight observed weekly. In contrast,
untreated diabetic rats experienced a sharp rise in blood glucose with stunted body weight.
Nutrigenomic studies were conducted to identify the mechanisms that support the
effectiveness of SCOBY papaya beverage as an anti-diabetic therapy. Evidence from
quantitative polymerase chain reaction (qPCR) analysis disclosed significant higher
expression on gene markers related to insulin receptor substrate 1 (Irs1), glucose
transporter (Slc2a8) and glutathione S-transferase mu 1 (Gstm1), but lower expression of
gene markers indicative of diabetes complications and inflammation e.g., tissue inhibitors
of metalloproteinase 1 (Timp1), nuclear factor kappa B subunit 1 (Nfkb1) and nitric oxide
2 (NOS2) in diabetic rats treated with SCOBY papaya beverage and Metformin (p<0.05).
SCOBY papaya treated diabetic rats showed an increment of short chain fatty acids
content and gut microbiota enriched with some beneficial microbes particularly for
Alloprevotella, Ruminococcus 1, Lachnospiraceae NK4A136, Prevotellaceae UCG-001
and Prevotellaceae NK3B31 compared to untreated diabetic rats. These data support the
effectiveness of SCOBY papaya as a functional beverage in improving intestinal health by
changing the environment of the microbiome of diabetic rats, in turn offering costeffective food therapies in blood glucose regulation.
KRL Rheostatik : Angkutan Kereta Listrik di Jabodetabek (1977 – 1988)
Authors: Raichan Ahmad Mulhaim , Humaidi Humaidi , Marta Nur Aeni
Published: January 2023

Tulisan ini mengkaji sejarah pembangunan infrastruktur kereta api di Jabotabek pada masa Orde Baru yang dimana dari masa sebelum dan sesudahnya mengalami pasang – surut setiap perkembangannya. Kajian dalam artikel ini berisikan tentang dinamika peristiwa yang membawa perkembangan kereta api di Jabotabek dari zaman akhir Orde Lama hingga Orde Baru. Dimulai dari kondisi perkembangan perkeretaapian di Jabotabek pada era Orde Lama dan segala keterpurukannya hingga memasuki pergantian rezim pemerintahan menjadi Orde Baru yang menjadi tonggak sejarah perkembangan perkeretaapian dan dinamika sosial kawasan Jakarta dan sekitarnya. Pada masa Orde Baru dimulai dari pengembangan kawasan urban di Jabotabek, peremajaan sarana kereta api komuter Jabotabek, pembangunan infrastruktur untuk meningkatkan kapasitas penumpang urban di Jabotabek dari pembangunan jalur ganda, pembangunan jalur layang, perluasan jaringan kereta api, pembangunan sarana pendukung, dan lain – lain. Selain itu dalam penulis juga akan menjelaskan perkembangan perkeretaapian yang dikembangkan dalam negeri seperti pembuatan kereta api listrik (KRL) dalam negeri yang dikembangkan oleh Industri Nasional Kereta Api (INKA) yang turut menjadi bagian dalam modernisasi sarana perkeretaapian di Jabotabek.
Pengaruh Model Flipped Classroom Terhadap Kemampuan Berpikir Kritis Pada Pembelajaran Sejarah Siswa SMAI Almaarif Singosari Malang
Authors: Sania Nahdia Riza , Sayono Joko , Khakim Moch. Nurfahrul Lukmanul
Published: January 2023

Tujuan ditulisnya artikel ini adalah untuk memaparkan pengaruh model flipped classroom terhadap kemampuan berpikir kritis pada pembelajaran sejarah siswa kelas X SMAI Almaarif Singosari Malang. Alasan penelitian ini dilaksanakan adalah bersumber pada permasalahan yang didapatkan ketika pengamatan awal, yaitu aspek berpikir siswa pada pembelajaran sejarah masih berada pada tingkat pengetahuan dan menghafal belum pada aspek berpikir kritis. Selama proses pembelajaran sejarah sebenarnya mengarahkan siswa untuk memaknai serta memahami peristiwa sejarah. Melalui hal tersebut, upaya yang dapat dilakukan untuk meningkatkan kemampuan berpikir kritis siswa adalah dengan diterapkannya model flipped classroom pada pembelajaran sejarah. Metode penelitian yang dipilih adalah metode kuantitatif jenis kuasi ekperimen dengan desain kelompok kontrol tidak setara. Teknik pengumpulan data memakai instrumen tes dengan bentuk soal pilihan ganda beralasan. Teknis analisis data dilakukan dengan uji normalitas, uji homogenitas, dan uji t. Hasil penelitan menunjukkan bahwa peningkatan data nilai kelas eksperimen pada nilai pre-test ke nilai post-test yaitu meningkat sebesar 53,29 % dengan nilai gain 22,68. Berbeda dengan data nilai kelas eksperimen, data nilai kelas kontrol mengalami peningkatan sebesar 32,27 % pada nilai pre-test ke nilai post-test-nya dengan nilai gain 13,07. Berdasarkan analisis data, didapatkan hasil thitung 4,135 > ttabel 2,012 dengan sig. 0,000 < sig α 0,05. Melalui hal tersebut kesimpulan yang didapatkan adalah model flipped classroom berpengaruh terhadap kemampuan berpikir kritis siswa kelas eksperimen.