bluuebunny/crossref_metadata_2025 huggingface dataset:
ENHANCING THE 5E LEARNING MODEL (ENGAGEEXPLORE-EXPLAIN-ELABORATE-EVALUATE) AMONG UNIVERSITY STUDENTS IN KOSOVO
Authors: Bekteshi, Edita , Avdiu Eliza , Xhaferi Brikena
Published: October 2022

The aim of this study was to investigate the application of the 5E Learning Model (Engage-Explore-Explain-Elaborate-Evaluate) among university teachers, to understand how teachers deliver each ‘E’ phase at the Faculty of Education, and to evaluate whether they pay similar attention to all phases. The sample of the study consisted of 139 university students who responded to a standardized online questionnaire regarding the 5E Learning Model. The results revealed that all phases of the 5E Model were covered while teaching the tertiary level students; however, the initial phase, the engagement phase, was paid less attention compared to the other ‘E’ phases. The students also considered that most activities were performed in the exploration and explanation phase, reasoning that they are hands-on phases. Although all phases of the 5E Model were demonstrated while teaching, the conclusion is that not all are similarly distributed. The study recommends that the same attention should be paid to all phases of the 5E Learning Model. The practice and implementation of each phase while teaching and learning helps develop life-long learning and teaching skills. Thus, it should be thoroughly introduced, explained and revised for the purpose of its further appropriate and easy application by the students at the Faculty of Education in their future teaching.
Evaluation on fatigue behaviour of spot-welded joint under low blow impact treatment
Authors: Padzi Mahfodzah , Ghazali Farizah Adliza
Published: October 2022

Welding is used widely in modern industries to combine parts needed complete a product. In this paper, we investigated the effect of post-weld impact treatment (PWIT) on spot-weld joints and evaluate the tensile and fatigue properties of the specimens. Currently, there is no simple failure criterion capable of predicting the strength of a spot weld under different loading conditions. The reliability of spot-welded structures treated with PWIT in terms of fatigue integrity could be understood more by the end of this research. The result showed that not only the tensile properties of PWIT specimens give an improvement, but there was also a significant increase in the fatigue life of the treated specimens.
Multiple linear regression parameters for determining fatigue-based entropy characterisation of magnesium alloy
Authors: Fauthan Mohd 'Akashah , Abdullah Shahrum , Abdullah Mohamad Faizal , Mohamed Intan Fadhlina
Published: October 2022

This paper presents the development of the multiple linear regression approach based on the stress ratio and applied load that was assessed using entropy generation. The energy dissipation is associated with material degradation to determine the fatigue life with consideration to the irreversible thermodynamic framework. This relationship was developed by predicting a complete entropy generation using a statistical approach, where a constant amplitude loading was applied to evaluate the fatigue life. By conducting compact tension tests, different stress ratios were applied to the specimen. During the tests, the temperature change was observed. The lowest entropy generation was 2.536 MJm-3 K-1 when 3,000N load with a stress ratio of 0.7 was applied to the specimen. The assumptions of the models were considered through graphical residual analysis. As a result, the predicted regression model based on the applied load and stress ratio was found to agree with the results of the experiment, with only 9.3% from the actual experiment. Therefore, the entropy generation can be predicted to access the dissipated energy as an irreversible degradation of a metallic material, subjected to cyclic elastic-plastic loading. Thermodynamic entropy is shown to play an important role in the fatigue process to trace the fatigue life.
Influence of manufacturing shrinkage and microstructural features on the strength properties of carbon fibers/PEEK composite material
Authors: Lomakin Evgeny , Fedulov Boris , Fedorenko Alexey
Published: October 2022

This research discusses the micromechanical modelling for thermoplastic composite material. Elastoplastic and damage model for PEEK matrix composite with the dependency of properties to stress state is presented. Plasticity initiation conditions and failure criterion are analyzed. The influence of manufacturing residual stresses is considered. All typical engineering experiments for neat PEEK under different stress state are good predicted by the model. Numerical experiment for macro-properties estimation based on micromechanical model is conducted and the results are compared with the test data.
The P-h2 relationship as a function of (hf/hm) in indentation
Authors: Habibi Samir
Published: October 2022

In the present study, a semi-empirical modeling of the mechanical response in pile-up mode is obtained by deriving the load-depth relationship during the indentation loading cycle. The advantage compared to the relations previously used is that this new expression is a function of the predictable criterion of the mode of deformation, (hf/hm), which makes it possible to distinguish the sink-in mode from the pile-up mode. A comparison between the proposed expression and the results of the instrumented indentation tests shows excellent agreement.
What would apophatic Action Research look like? Learning to consider delicatematters of silence and wonder in professional practices
Authors: Hansen Finn Thorbjørn
Published: October 2022

Inspired by an ‘apophatic turn’ in theology, philosophy and art, and with insights from existential phenomenology, the article encourages us to step back as actors in order to let life or the phenomenon itself act upon us. This kind of apophatic thinking is not so far away from the thinking of the Norwegian philosopher Olav Eikeland when he describes “Insider and Praxis Action Research”. And yet, the apophatic potentials in his way of understanding action research are here elaborated by pointing to three dimensions: the Knowledge-, Being- and Mystery dimensions in a praxis, and to the four ways of seeing praxis from within both a “gnoseology” and an “agnoselogy”. The latter being led by a deep sense of wonder followed by what Daoist’s call Wu Wei or “effortless actions”.
Praxeological dialogues from within, handling tensions in dialogical praxis-oriented Action Research
Authors: Torbjørnsen Halås Catrine
Published: October 2022

This paper addresses the need to develop concepts and terminology more and better adjusted to knowledge production with and from within practices, and help handle tensions between research and practice in Dialogical Praxis- oriented Action Research. Building on Olav Eikeland’s ideas of dialogues towards Praxis-based Theoria, supported by Hanna Arendt’s perspectives on action, and based on experiences from a concrete project, the question explored, is whether Jakob Meløe’s praxeological perspectives can give us concepts and terminology which can help us handle this challenge. After describing the ideas and methodology of the praxeology, the author discusses its potential impact; To support dialogical deliberative learning processes, acknowledging knowledge as an open-ended question of becoming, and praxis as a form of relational and ethical kind of knowing, empowering the subjects to create new beginnings, engaged in the never-ending process of change.
Fiberoptic endoscopic evaluation of swallowing as a tool to facilitate dysphagia rehabilitation following a salvage hemi-glossectomy: Case report
Authors: Simson Gavriella , Govender Roganie
Published: October 2022

Background: Dysphagia is a common consequence of tongue cancer and its treatment, with the possibility of long-term diet modification and feeding tube dependence. This is likely to have an impact on the activity, participation and psychological wellbeing of the individual. Objective: This case report presents the use of fiberoptic endoscopic evaluation of swallow (FEES) as a tool to support dysphagia rehabilitation through providing visual feedback following a salvage hemi-glossectomy for management of a recurrent squamous cell carcinoma (SCC) in the right anterolateral tongue. Methods: Clinician-rated and patient-reported outcome measures were used to assess the effectiveness of FEES as a tool to facilitate dysphagia rehabilitation. These measures include the: Performance Status Scale for Head and Neck (PSS-HN) cancer patients, 100 mL water swallow test (WST), Penetration-Aspiration Scale (PAS), the Yale Pharyngeal Residue Severity Rating Scale, and the Functional Intraoral Glasgow Scale (FIGS). Results: No Statistical tests were performed on this single case, however the results demonstrate a notable clinical improvement in all postoperative outcome measures at 12-months when compared with those taken two-months postoperatively. Conclusion: Use of sequential FEES could enhance patient engagement and inform dysphagia rehabilitation following hemi-glossectomy.
Decreased muscle strength and scapular muscle endurance associated with shoulder function after neck dissection
Authors: Özyürek Seher , Cansu Kalkan Aybüke , Doğan Ersoy , Melike Bülbül Hande , Akif Kamar Mehmet , Balci Ali , Ömer İkiz Ahmet , Keskinoğlu Pembe , Genç Arzu
Published: October 2022

BACKGROUND: Shoulder disability is a common problem following neck dissection. Even if nerve structures are preserved, this may occur after the surgery. OBJECTIVE: The primary aim was to research changes in rotator cuff and scapular muscles strength, and scapular muscle endurance after neck dissection in patients with head and neck cancer. The secondary aim was to investigate the relationship between these changes and postoperative shoulder function. METHODS: This cross-sectional and prospective follow-up study included 14 patients who underwent neck dissection (9 unilateral and 5 bilateral). Evaluations were performed preoperatively and at 3 months postoperatively. Muscle strength measurements, including trapezius, serratus anterior, and rotator cuff muscles, were obtained using a handheld dynamometer. The scapular muscle endurance test was used for muscle endurance assessment. Postoperative shoulder function was evaluated using Constant-Murley shoulder score. RESULTS: A decrease in muscle strength and the scapular muscle endurance test was found at 3 months postoperatively, except for the subscapularis muscle strength (p< 0.05). There were moderate to strong correlations between Constant-Murley shoulder score and percentage changes in muscle strength and the scapular muscle endurance test, except for the upper trapezius muscle strength (p< 0.05). CONCLUSIONS: Muscle strength and scapular muscle endurance may reduce following neck dissection. These reductions are associated with postoperative shoulder function. Thus, muscle strength and endurance training may be beneficial for early postoperative rehabilitation in patients with head and neck cancer.
Risk factors for early complications following arthroplasty in elderly patients with a femoral neck fracture
Authors: Wang Junfeng , Zhao Changsheng , Yang Bin
Published: October 2022

BACKGROUND: Early complications after arthroplasty for geriatric femoral neck fractures are known to negatively affect postoperative recovery and increase postoperative mortality. Identifying risk factors associated with early complications after arthroplasty may offer an opportunity to address and prevent these complications in many patients. OBJECTIVE: To evaluate preoperative risk factors for early complications after arthroplasty in elderly patients with a femoral neck fracture. METHODS: 119 elderly patients with femoral neck fractures who had been treated with arthroplasty (hemiarthroplasty or total hip arthroplasty) between December 2015 and December 2018 were retrospectively analysed. Early complications were defined as any complications that did not exist preoperatively, and occurred during hospital stay after arthroplasty Preoperative clinical, epidemiological and laboratory data were collected. Binary univariable and multivariable logistic regression analysis were applied to identify predictors of early complications after arthroplasty for geriatric femoral neck fractures. RESULTS: Median age of all patients was 80.0 (IQR 74.0–84.0) years. We identified 28 (23.5%) early complications after arthroplasty. Univariable logistic regression analysis found that preoperative body mass index (BMI p= 0.031), C-reactive protein (CRP p= 0.017) and serum Albumin (p= 0.006) were potential risk factors for early complications. Then preoperative BMI, CRP and serum Albumin were stratified and used for multivariable logistic regression analysis The multivariate logistic regression analysis showed that preoperative higher BMI (⩾ 28 kg/m2; OR 10.440; 95% CI 2.674–41.170; p= 0.001) and lower serum Albumin (⩽ 35 g/L; OR 3.933; 95% CI 1.509–10.800; p= 0.006) were independent risk factors for early complications after arthroplasty in geriatric femoral neck fractures. However, preoperative higher CRP levels (> 10 mg/L; OR 1.139; 95% CI 1034–1428; p= 0.833) was found to be not an independent risk factor for early complications. CONCLUSION: Our results demonstrate that obesity and hypoalbuminemia are independent predictors for early complications during hospital stay after arthroplasty, which should be meticulously noted to minimize these risk factors in geriatric femoral neck fractures.
The great wave: The increasing demand for digital competence within the public sector
Authors: Mankevich Vasili , Magnusson Johan , Svahn Fredrik
Published: October 2022

The increasing diffusion of digital government has led to numerous reports on both significant progress and failure in terms of digital transformation. Previous research highlights the role of digital competence as a pre-requisite for successful digital transformation, yet few studies have addressed the actual state of digital competence demand in the public sector. We study the development of digital competence demand in the Swedish public sector for the period 2006–2020. Utilizing a complete, open dataset of all job postings, we find that the digital competence demand in public sector recruitment has significantly increased. At the same time, the public sector lags behind the private in terms of digital competence demand. These findings are discussed from the perspectives of both the need for further research into human resource-related aspects of digital government and the national digital government policy. We also discuss the potential impact of disruptive events such as the COVID-19 pandemic and the 2009 financial crisis on digital competence demand.
Where Do CABs Exist? Verification of a specific region containing concave Actin Bundles (CABs) in a 3-Dimensional confocal image
Authors: Park Doyoung
Published: October 2022

CABs (Concave Actin Bundles) are oriented against the scaffold transversally in a manner different from traditional longitudinal F-actin bundles. CABs are present in a specific area, and do not exist in random areas. Biologically, CABs are developed to attach cells to fibers firmly so that CABs are found near cells. Based on this knowledge, we closely examined 3D confocal microcopy images containing fiber scaffolds, actin, and cells. Then, we assumed that the areas containing high values of compactness of fiber, compactness of actin, and density of cells would have many numbers of CABs. In this research, we wanted to prove this assumption. We first incorporated a two-point correlation function to define a measure of compactness. Then, we used the Bayes’ theorem to prove the above assumption. As the assumption, our results verified that CABs exist in an area of high compactness of a fiber network, high compactness of actin distribution, and high density of cells. Thus, we concluded that CABs are developed to attach cells to a fibrillar scaffold firmly. This finding may be further verified mathematically in future studies.
Multi-objective genetic algorithm for mobile robot path planning in industrial automation
Authors: Suresh K.S. , Ravichandran K.S. , Venugopal S.
Published: October 2022

Due to the problem’s high level of complexity, the optimization strategies used for the mobile robot path planning problem are quite expensive. The Mobile Robot Path Search based on a Multi-objective Genetic Algorithm (MRPS-MOGA) is suggested as a solution to the complexity. The MRPS-MOGA resolves path planning issues while taking into account a number of different factors, including safety, distance, smoothness, trip duration, and a collision-free path. In order to find the best approach, the suggested MRPS-MOGA takes into account five main objectives. The MOGA is used to pick the best path from a variety of viable options. Paths produced at random are used to initialise the population with viable paths. By using objective functions for various objectives, the fitness value is assessed for the quantity of potential candidate paths. In order to achieve diversity in the population, another GA operator mutation is carried out at random on the sequence. Once more, the individual fitness criterion is supported in order to derive the best path from the population. With various situations, an experimental research of the suggested MRPS-MOGA is conducted. The outcome shows that the suggested MRPS-MOGA performs better when choosing the best path with the least amount of time complexity. MRPS-MOGA is more effective than the currently used approaches, according to the experimental analysis.
A new authentication scheme based on monogenic semigroup
Authors: Abughazalah Nabilah , Khan Majid , Yaqoob Naveed , Munir Noor , Hussain Iqtadar
Published: October 2022

The reduction of constrained mathematical structures leads us to generalize any abstract structures. Using minimum conditions to construct a secure and robust component of the modern encryption algorithm is one crucial problem in multimedia security. With this understanding, we have proposed a new algebraic structure, namely monogenic semigroup, to construct a digital information authentication scheme. Authentication is always completed at the beginning of the application, before any throttling or approval checks are performed, and before any other code is allowed to begin running in the background. Many authentication schemes offer a complex structure for implementation in cryptosystems and applications. The anticipated mechanism uses a simple mathematical structure having the least conditions as compared to other mathematical structures. The suggested scheme provides structures for the authentication of text messages and images.
A novel hybrid machine learning approach for traffic sign detection using CNN-GRNN
Authors: Pandurangan Raji , Jayaseelan Samuel Manoharan , Rajalingam Suresh , Angelo Kandavalli Michael
Published: October 2022

The traffic signal recognition model plays a significant role in the intelligent transportation model, as traffic signals aid the drivers to driving the more professional with awareness. The primary goal of this paper is to proposea model that works for the recognition and detection of traffic signals. This work proposes the pre-processing and segmentation approach applying machine learning techniques are occurred recent trends of study. Initially, the median filter & histogram equalization technique is utilized for pre-processing the traffic signal images, and also information of the figures being increased. The contrast of the figures upgraded, and information about the color shape of traffic signals are applied by the model. To localize the traffic signal in the obtained image, then this region of interest in traffic signal figures are extracted. The traffic signal recognition and classification experiments are managed depending on the German Traffic Signal Recognition Benchmark-(GTSRB). Various machine learning techniques such as Support Vector Machine (SVM), Extreme Learning Machine (ELM), Linear Discriminant Analysis (LDA), Principal Component Analysis (PCA), Convolutional neural network (CNN)- General Regression Neural Network (GRNN) is used for the classification process. Finally, the obtained results will be compare in terms of the performance metrics like accuracy, F1 score, kappa score, jaccard score, sensitivity, specificity, recall, and precision. The result shows that CNN-GRNN with ML techniques by attaining 99.41% accuracy compare to other intelligent methods. In this proposed technique is used for detecting and classifying various categories of traffic signals to improve the accuracy and effectiveness of the system.
Somewhat omega continuity and somewhat omega openness in soft topological spaces
Authors: Al Ghour Samer
Published: October 2022

In this paper, we introduce soft somewhat ω-continuous soft mappings and soft somewhat ω-open soft mappings as two new classes of soft mappings. We characterize these two concepts. Also, we prove that the class of soft somewhat ω-continuous (resp. soft somewhat ω-open) soft mappings contains the class of soft somewhat continuous (resp. soft somewhat open) soft mappings. Moreover, we obtain some sufficient conditions for the composition of two soft somewhat ω-continuous (resp. soft somewhat ω-open) soft mappings to be a soft somewhat ω-continuous (resp. a soft somewhat ω-open) soft mapping. Furthermore, we introduce some sufficient conditions for restricting a soft somewhat ω-continuous (resp. soft somewhat ω-open) soft mapping to being a soft somewhat ω-continuous (resp. soft somewhat ω-open) soft mapping. In addition to these, we introduce extension theorems regarding soft somewhat ω-continuity and soft somewhat ω-openness. Finally, we investigate the correspondences between the novel notions in soft topology and their general topological analogs.
Experimental validation of cold neutron source performance with mesitylene moderator installed at RANS
Authors: Ikeda Yujiro , Teshigawara Makoto , Yan Mingfei , Iwamoto Chihiro , Fujita Kunihiro , Abe Yutaka , Wakabayashi Yasuo , Taketani Atsushi , Takanashi Takaoki , Harada M. , Hashiguchi Takao , Yamagata Yutaka , Matsuzaki Yoshio , Ma Baolong , Takamura Masato , Mizuta Maki , Goto Makoto , Ikeda Shota , Kobayashi Tomohiro , Otake Yoshie
Published: October 2022

The RANS (RIKEN Accelerator driven Neutron Source), one of compact accelerator neutron sources (CANS), tries to expand its performance by installing a cold neutron which may provide new opportunities in many applications. RANS is a low power CANS with a proton beam of 7 MeV and 100 µA at maximum. A moderator system was constructed based on results of optimization design study with mesitylene. Recently, we have done performance tests aiming at showing characteristics as cold neutron source. Cryogenic mesitylene moderator was installed on a plug with a new target moderator reflector configuration of RANS. Experiment using a gas electron multiplier (GEM) detector was carried out to measure neutron spectra of the cold moderator. This paper describes performance of the cold moderator in terms of 1) Cold neutron gain of optimization design with respect to a polyethylene moderator, 2) Temperature dependency of cold neutron spectrum flux regarding scattering kernel (SK), and 3) comparison between experiment and calculation. A note is given for comparison between calculations with different SKs available. Also, two-dimensional imaging of cold and thermal neutron spectrum flux on the viewed surface is shown with a pinhole slit configuration.
Expression profile of circular RNAs in patients with unstable angina
Authors: Yang Hai-Ping , Chen Yue-Ling , Liu Zong-Jian , Hao Yi , Chen Lin , Zhang Zhen-Hua , He Ning , Wang Jing
Published: October 2022

BACKGROUND: Circular RNAs (circRNAs) are a new class of noncoding RNAs, which interfere with gene transcription by absorbing microRNAs (miRNAs). OBJECTIVE: The expression profile and roles of circRNAs in unstable angina (UA) patients remains unclear. METHODS: An initial screening of circRNA expression by microarray analysis was performed using blood samples from three pairs of UA patients and matched healthy individuals. The differential expression of the chosen six circRNAs from the results of the microarray analysis was validated by quantitative real-time polymerase chain reaction (qRT-PCR). RESULTS: The microarray results demonstrated that some circRNAs were markedly different in UA patients, when compared with matched healthy individuals. In these UA patients, 22 circRNAs were upregulated and six circRNAs were downregulated when a P-value of < 0.05 was considered as a cut-off level and the fold change was > 1.5. Among the six circRNAs chosen for further analysis, qRT-PCR identified that five of these were upregulated, and the remaining circRNA was downregulated. By comparing the outcome of the six candidate circRNAs between the circRNAs microarray assay and RT-PCR validation, it was found that four circRNAs (hsa_circ_0002229, hsa_circ_0005580, hsa_circ_0046667, and hsa_circ_0001451) had the same variation trend. CONCLUSION: The present study provided the expression profile of circRNAs in UA patients. Moreover, some circRNAs have the potential to be biomarkers for the detection of UA patients. Further studies with a larger population will focus on hsa_circ_0002229, hsa_circ_0005580, hsa_circ_0046667 and hsa_circ_0001451.
Microencapsulação: uma Alternativa Promissora para Preservação de Produtos Naturais
Authors: Foglio M. A. , Servat L. , Spindola H. M. , Rodrigues R. A. F.
Published: October 2022

Os estudos e a crescente utilização dos fitoterápicos fizeram despertar em todo o mundo uma preocupação com a sua eficácia, pois o processamento inadequado das plantas pode ocasionar degradação das moléculas e conseqüente perda da atividade farmacológica. Entre as alternativas que podem ser utilizadas para preservar as características de extratos vegetais, destaca-se a encapsulação em micropartículas. No presente levantamento, demonstraram-se brevemente os principais métodos de microencapsulação, materiais encapsulantes, além de aplicações e benefícios desse processo. As vantagens apresentadas motivam a continuidade dos estudos da microencapsulação, visando a preservação das características originais de produtos naturais, além de estratégias em busca da padronização desses produtos.
Normas Recentes e as Políticas para Fitoterápicos e Fitoterapia no Brasil
Authors: Boorhem R. L.
Published: October 2022

Apresenta-se aqui uma análise sucinta das normas mais recentes para a regulação do uso de fitoterápicos e drogas vegetais no Brasil.
Piper umbellatum L. = Pothomorphe umbellata (L.) Miq.
Authors: Gilbert B. , Favoreto R.
Published: October 2022

Este estudo se baseia na literatura convencional e científica, com o objetivo de compilar as informações relevantes à espécie Piper umbellatum L. [Pothomorphe umbellata (L.) Miq.] relacionadas ao seu potencial medicinal, e como matéria-prima para produtos farmacêuticos e cosméticos.
Optoacoustic characterization of prostate cancer in an in vivo transgenic murine model
Authors: Patterson Michelle , Riley Christopher B. , Kolios Michael , Whelan William M.
Published: October 2022

Optoacoustic (OA) imaging was employed to distinguish normal from neoplastic tissues in a transgenic murine model of prostate cancer. OA images of five tumor-bearing mice and five age-matched controls across a 14  mm×14  mm region of interest (ROI) on the lower abdomen were acquired using a reverse-mode OA imaging system (Seno Medical Instruments Inc., San Antonio, Texas). Neoplastic prostate tissue was identified based on the OA signal amplitude in combination with spectral analysis of the OA radio frequency (RF) data. Integration of the signal amplitude images was performed to construct two-dimensional images of the ROI. The prostate tumors generated higher amplitude signals than those of the surrounding tissues, with contrast ratios ranging from 31 to 36 dB. The RF spectrum analysis showed significant differences between the tumor and the control mice. The midband fit was higher by 5 dB (62%), the intercept higher by 4 dB (57%) and the spectral slope higher by 0.4  dB/MHz (50%) for neoplastic prostate tissue compared to normal tissues in the control mice. The results demonstrate that OA offers high contrast imaging of prostate cancer in vivo. 
Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes
Authors: May Jonathan
P. , Hysi Eno , Wirtzfeld Lauren A. , Undzys Elijus , Li Shyh-Dar , Kolios Michael
Published: October 2022

Imaging methods capable of indicating the potential for success of an individualized treatment course, during or immediately following the treatment, could improve therapeutic outcomes. Temperature Sensitive Liposomes (TSLs) provide an effective way to deliver chemotherapeutics to a localized tumoral area heated to mild-hyperthermia (HT). The high drug levels reached in the tumor vasculature lead to increased tumor regression via the cascade of events during and immediately following treatment. For a TSL carrying doxorubicin (DOX) these include the rapid and intense exposure of endothelial cells to high drug concentrations, hemorrhage, blood coagulation and vascular shutdown. In this study, ultrasound-guided photoacoustic imaging was used to probe the changes to tumors following treatment with the TSL, HaT-DOX (Heat activated cytoToxic). Levels of oxygen saturation (sO2) were studied in a longitudinal manner, from 30 min pre-treatment to 7 days post-treatment. The efficacious treatments of HT-HaT-DOX were shown to induce a significant drop in sO2 (>10%) as early as 30 min post-treatment that led to tumor regression (in 90% of cases); HT-Saline and non-efficacious HT-HaT-DOX (10% of cases) treatments did not show any significant change in sO2 at these timepoints. The changes in sO2 were further corroborated with histological data, using the vascular and perfusion markers CD31 and FITC-lectin. These results allowed us to further surmise a plausible mechanism of the cellular events taking place in the TSL treated tumor regions over the first 24 hours post-treatment. The potential for using photoacoustic imaging to measure tumor sO2 as a surrogate prognostic marker for predicting therapeutic outcome with a TSL treatment is demonstrated.
Evidence-based practice and undergraduate nursing curriculum: Trends and perspectives
Authors: Baixinho Cristina , Ferreira Oscar , Medeiros Marcelo , Oliveira Ellen
Published: October 2022

Evidence-based practice is recognized as key to improving the quality of health care, increasing patient safety, controlling costs, and improving outcomes for people with healthcare and nursing needs. Despite its advantages, the use of evidence in healthcare settings is not yet a standard of healthcare in the world. How can students learn and develop skills to use evidence-based-practice (EBP) in current nursing curriculum and how can researchers work with students and clinical professionals to increase EBP? Changes in nursing education will require close collaboration with clinical contexts because learning about evidence takes place outside the classroom.
Implementing a nurse-led quality improvement project in nursing home during COVID 19 pandemic: A qualitative study
Authors: Gonella Silvia , Di Giulio Paola , Angaramo Marianna , Dimonte Valerio , Campagna Sara , Brazil Kevin , MySupport Study Group
Published: October 2022

Background: There is broad consensus that the quality of nursing home (NH) care is a research priority to advance NH practice. However, NHs often fail to implement quality improvement (QI) research projects and complex circumstances such as Coronavirus disease 19 (COVID-19) pandemic may further hinder compliance. This study aims to describe the challenges associated with implementing a nurse-led QI project in NH during COVID-19 pandemic and potential strategies for their overcoming. Methods: A descriptive qualitative study was performed, and three data collection strategies employed, including: 1. semi-structured, open-ended interviews with follow-up questions (one NH manager, three members of the NH staff, and two family caregivers of people with advanced dementia); 2. research diary; and 3. in-the-field-notes. A combined deductive and inductive content analysis was adopted to analyze data. Results: Challenges may be anticipated or unanticipated. QI projects should include preliminary assessments to identify the willingness to change and establish partnerships at multiple levels with all stakeholders, adjust the implementation plan to the organizational context, and be open to ongoing changes. Conclusions: Early and regular engagement of stakeholders strengthen relationships. Moreover, an ongoing reflective practice throughout the entire implementation process promotes openness to change, and finally learning and improvement.
SELECTION MODELS OF THE JAYA UTAMA AND SUGENG RAHAYU BUS ROUTES USING THE STAGED LOADING METHOD (CASE STUDY: PURABAYA TERMINAL – TERBOYO TERMINAL
Authors: Rokhimi Fauzan , Utomo Nugroho , Sholichin Ibnu
Published: October 2022

Pattern of interaction that occurs between the City of Surabaya and the City of Semarang is not only limited to economic factors but more than that the pattern of interaction takes place in all aspects of human life. People who are outside the Semarang City area will try to choose the fastest route from several routes that connect between the zones of origin to Semarang City. This research was conducted based on the factors that influence the process of selecting travel routes from the city of Surabaya to the city of Semarang using the inter-city inter-provincial bus (AKAP) public transportation. 

This study uses a gradual loading method because this method can be used to determine the relationship between traffic flow and vehicle travel time, not depending on the assumptions of road users and the characteristics of the road network.

The results of simple linear regression analysis, obtained a flow-cost relationship model on route A (Terminal Purabaya - Nganjuk - Ngawi - Solo - Ungaran - Terminal Terboyo) the form of the equation is YA = 48.937 + 0.022X. While the flow-cost relationship model on route B (Terminal Purabaya - Gresik - Lamongan - Tuban - Rembang - Kudus - Terminal Terboyo) the form of the equation is YB = 36,822 + 0.034X. The coefficient of determination (R2) on route A is 0.6 and on route B the result is 0.4. The final result of loading the travel route with a uniform loading fraction of 5% obtained a Wardrop balance convergence value of 0.003.  

Keywords: simple linear regression analysis, stepwise loading method, travel route selection.
VALUATION OF SAFETY APPLICATION OF LAND TRANSPORTATION ON PORONG ARTERIAL ROAD – PURWOSARI ROADWAY STA 30+00 – STA 61+400
Authors: Kulsum Umi , Sholichin Ibnu
Published: October 2022

Highways can have an impact on the social and economic development of the surrounding community as well as progress in the industrial sector. Road safety is an important aspect that must be considered. The main problem that often occurs in these accidents apart from human factors can also be caused by road infrastructure. Along Porong Arterial Road – Roadway Purwosari STA 30+00 – 61+400 in certain locations along the road there are inadequate road completeness facilities such as PJU lights that do not turn on or PJU distances that are too far away, pavement damage and road markings less clear. Based on these field conditions, it is necessary to evaluate traffic safety based on the main attributes that must be repaired using the Importance Performance Analysis method, namely the street lights are on well, damaged roads have been replaced/repaired and roads are free from damage such as waves, potholes. and puddles. According to the weighting with the EAN (Equivalent Accident Number) method based on data from the Police Resort of Sidoarjo Regency and Pasuruan Regency in 2016 - 2020 it was 486, located at STA 38+00 – 39+00 with a total of 590 cases. The blackspot point is located at the Apolo Roundabout with (R analysis) > (R Existing) = 30 m > 18.03 concluded that it does not meet the standards and the value of side freedom and (E analysis) < (E existing) = 5m < 7 m is concluded to have met the standard.
The Effect Of The Use of Aluminum Fiber As A Partial Substitution of Fine Aggregate on The Compressive Strength of Concrete
Authors: Affandy Nur Azizah , Sucahyo Muklis , Basuki Agus Pindo
Published: October 2022

Penelitian ini bertujuan untuk memanfaatkan limbah serat aluminium sebagai bahan pengganti campuran beton non struktural, serta untuk mengetahui pengaruh penambahan serat aluminium terhadap kuat tekan beton. Penelitian ini menggunakan benda uji berbentuk silinder dengan ukuran 15x30 cm, dengan penambahan limbah serat aluminium divariasikan dari 0%, 0,2%, 0,4%, dan 0,8% dengan jumlah benda uji sebanyak 12 benda uji. Pengujian kuat tekan beton dilakukan SNI 1974-2011 pada umur 7 hari dan 28 hari. Hasil analisis penambahan limbah serbuk aluminium pada campuran beton dengan beberapa variasi mengakibatkan penurunan berat jenis beton. Pengaruh penggunaan limbah serat aluminium dalam campuran beton berpengaruh terhadap peningkatan dan penurunan kuat tekan beton. Untuk beton berumur 28 hari, semua varian telah mencapai kuat tekan beton rencana (14,5 MPa). Hasil regresi hubungan antara peningkatan kuat tekan rata-rata beton umur 7 hari dengan persentase LSA menyatakan bahwa dapat diketahui hubungan yang terbentuk antara penambahan variasi LSA dengan kuat tekan beton. bisa dilihat.
MULTIPLE IMPACT ANALYSIS OF PILING WORK ON HIGH WAY PROJECTS USING THE EVM METHOD
Authors: Khosiin Mik Wanul , Gumanti Tatang Ari , Muktiyanto Ali , Hidayat Widi
Published: October 2022

A toll road is one of the economic growth facilities of a country, Indonesia in the last seven years has succeeded in building 1900 km and one of them is Trans-Java. The Gempol-Pasuruan section-2 toll road project is a densely populated route and there are many intersections in the form of roads and rivers so there are many overpass or underpass structures in the project. Although the bridge structure is a sub-project of the main road, if the productivity does not perform well, it will have a significant impact on the overall progress. Therefore, this study wants to analyze the multiple impacts of one of the critical works of the bridge project, such as the pilling work on the total toll road progress through the earn value management (EVM) method. EVM is a technique that is quite popular both among practitioners and academics; however, analysis of complex projects (main projects-sub projects) has never been carried out in-depth and it will be a unique challenge in this study. There are four steps in this research, the first step is project scheduling in which the engineer can use the previous database to prepare the work breakdown structure (WBS), work sequences, and project duration. The second step is the critical path process, at this stage, a slack analysis is carried out for each activity, and setting a network diagram to generate critical paths for the toll-bridge project. Resource management is the third step that involves a lot of documents from the market and internal databases, starting with assigning resources, inputting quantity and unit prices, and doing the leveling process so that the supply chain runs well. The last step is the earn value process, at this stage, the engineer only needs to input the project progress, set the baseline, and finally get the earn value project and project performance index consisting of SPI (schedule) and CPI (cost). Finally, after going through several stages of research, it has been proven that the pilling work is on a critical path and several scenarios must be carried out to maintain its productivity. Then, the average SPI value is 0.94 < 1, while the SPI value is 1 which means that the Gempol-Pasuruan section-2 toll road project is experiencing delays and is within the project budget. In conclusion, the application of the EVM method on MS. Project 2013 is able to evaluate complex projects well and several potential technologies can also be considered in further study to improve the performance.
METHOD OF EXPANDING THE SOLAR CELLS ABSORPTION SPECTRA BY APPLYING PYRAZOLINE LUMINOPHOR LAYER
Authors: Kazarova I.
Published: October 2022

An analysis of the industries for which the wide implementation of solar energy is currently considered relevant has been carried out. The aim of the study is to build a methodology for the synthesis of nanostructured pyrazoline dyes that can be used as a coating material for solar cells based on monocrystalline, polycrystalline and amorphous silicon, as well as the development of a system for evaluating the effectiveness and optimization of this methodology according to the target indicators calculated at the quantitative level. In order to build a holistic methodology for the synthesis of photovoltaic coating phosphor, the functions and arguments are defined in the article, on the basis of which the target performance indicators for compensating for the difference in the spectra of solar radiation and absorption of the solar cell substrate are further calculated. Factors for reducing the efficiency of photoelectric converters based on polycrystalline silicon have been determined. As part of the concept of broadening the solar cells absorption spectra by applying the luminophor layer, a method for the synthesis of the nanostructured pyrazoline photoluminescent dyes class is proposed. An experimental study was conducted based on the correlation of the solar radiation spectrum, the absorption spectrum of polycrystalline silicon, as well as the absorption and photoluminescence spectra of synthesized luminophores. A complex mathematical model has been developed for evaluating the effectiveness of the presented technique for expanding the absorption spectra of solar cells and optimizing the specified approach in accordance with the target indicators. The author has considered the procedure of synthesis of nanostructured pyrazoline dye and typical parameters of the procedure that affect the characteristics of this class of phosphors, as well as the corresponding designations. Determination of the general procedure for the synthesis and control of the characteristics of the photoluminescent coating material of the photovoltaic converter, as well as a series of experimental studies allowed the author to identify pyrazoline phosphors that are suitable as a coating material for a photovoltaic converter.
Keywords: solar cells, absorption spectrum, photoluminescence spectrum, pyrazoline luminophor, nanostructuring procedure, laser annealing, target functions.
MANAGEMENT OF THE SYSTEM «CDP DISPATCHER POWER SUPPLY SYSTEMS - PRODUCTION ENVIRONMENT» AS A TOOL FOR OPTIMIZATION OF WORKING CONDITIONS
Authors: Serikov Y.
Published: October 2022

Ensuring industrial safety, labor protection, health of workers, including in the field of electricity, is an urgent task today. This task is set out in the development strategies of the European Union, the United States, Canada and others. This position of the states is aimed at reducing the level of occupational injuries and occupational diseases, which is high, especially in the field of electricity in almost all countries. Analysis of the state of the solution of this problem shows that the working conditions of the staff of the power supply system, especially in the central control points, in many cases need to be improved. The study of the relationships in the system «dispatcher of the main control point of power supply systems - production environment» confirms the importance of solving the problem of improving their working conditions. The peculiarities of power supply system managers are revealed, which are due to the following two main facts. 1 - production activity of dispatchers of the central dispatching points is characterized by the considerable list of tasks which differ in character of the performed work. This necessitates frequent switching of their activities. This mode of operation causes significant psychophysiological loads in their body. 2 - the state of health directly affects the health and well-being of dispatchers during the work shift. This is especially true in emergencies, which require the maximum concentration of professional knowledge, the attention of dispatchers in developing the necessary solution to restore power. Thus, the task of ensuring proper (regulatory) working conditions, regulated by regulations, is complemented by the need to develop measures to optimize the regime «work – rest» during the work shift, ergonomics of the workplace. In this case, for example, while ensuring proper microclimatic conditions, it is necessary to ensure their optimal parameters, and the design or improvement of artificial lighting systems should be based on the qualitative characteristics of light flux. That is, the organization of the production environment should be improved not only taking into account changes in regulations, but also taking into account the latest advances in ergonomics, other areas in the field of providing a comfortable working environment. Based on this, the solution of the problem requires a comprehensive system approach. This approach is proposed to be implemented using the developed adaptive management system of working conditions, ergonomics, ie in general, the production environment in the central control point of the power supply system. A software algorithm for such a management system is presented. The presented methodology for developing an adaptive management system is universal. It can be implemented in power supply systems for various purposes.
Keywords: power supply systems, central control point, labor protection, management, reliability of power supply.
MODEL OF FUNCTIONING CEREALS SEED DELIVERY SYSTEM IN CONTAINERS FROM THE USA TO UKRAINE
Authors: Pavlenko O. , Muzylyov D.
Published: October 2022

The paper analyzed the current state and prospects for the development of grain seed delivery systems in international routes, including option using containers, which made it possible to form the study purpose in this research. The chosen topic is quite relevant because the rational organization of goods delivery in containers allows increasing the efficiency of transport systems functioning. The effective use of transport resources (ports, railway stations, trains, trucks, containers) is one of the directions to make delivery costs cheaper. The fact was established that considerable attention paid to the development of transport infrastructure, solving problems on the effective resources using, implementation of digital technologies and models designing of reliable delivery systems in previous scientific researches. A structural model has been designed, which consists of a system for delivering grain seeds in containers from the USA to Ukraine and is represented by the interaction of subsystems that have a significant impact on the functioning quality and take into account the possible risks associated with waiting for operations performance and the peculiarities of paperwork for international transportation. Five interaction schemes have been formed for participants of goods supply in containers based on used maritime routes, railway transport capabilities, a highways network and warehouse systems. These schemes identify the main departure ports in the United States (New York and Savannah) and destination ports in Europe (Rotterdam, Gdańsk and Odessa), as well as take into account the possibility of resources using of highway and railway transport in the European countries and Ukraine. Unit delivery costs were chosen as a parameter for evaluating an effective model selection during the week, influenced by cargo order intensities, cargo order volumes, and transportation mileages in a certain chain of the corresponding i-th transport kind. The designed models of the system functioning for delivering grain seeds in containers from the USA to Ukraine allow operators to take into account random factors influence, considering the peculiarities of performing relevant operations on different kinds of transport, assess the possibility of using transport resources, as well as determine the influence level of established parameters.
Keywords: model, delivery, grain, container, unit costs, international transportation.