bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-Existence of Endometriosis with Ovarian Dermoid Cysts: A Retrospective Cohort Study
Authors: Kalaitzopoulos Dimitrios Rafail , Samartzis Nicolas , Eberhard Markus , Grigoriadis Georgios , Miliaras Dimosthenis , Papanikolaou Alexis , Daniilidis Angelos
Published: October 2023

Both endometriosis and ovarian dermoid cysts are benign conditions characterized by the presence of well-differentiated tissues in ectopic locations. The presence and surgical excision of these entities can potentially impact ovarian reserves, contributing to reduced chances of future pregnancy. The objective of our study is to investigate the bidirectional association between endometriosis and ovarian dermoid cysts, as well as to analyze the clinical characteristics of patients diagnosed with both conditions. A retrospective cohort study was conducted, including women who underwent laparoscopy and received histological diagnoses of endometriosis and/or dermoid cysts between 2011 and 2019 at the Cantonal Hospital of Schaffhausen. We identified 985 women with endometriosis and 83 women with ovarian dermoid cysts. Among these groups, 22 women presented with both endometriosis and ovarian dermoid cysts. The majority of the above patients had endometriosis stage rASRM I-II (72.7%), with peritoneal endometriosis being the most common phenotype of endometriosis (77.2%). Out of the 14 patients with a desire for future pregnancy, the majority (11/14, 78.5%) had an EFI score of 7–8. The prevalence of bilateral ovarian dermoid cysts was higher in women with both ovarian dermoid cysts and endometriosis in comparison to women with ovarian dermoid cysts without endometriosis (18% vs. 6.5%). Our study revealed that 26.5% of women with ovarian dermoid cysts also had endometriosis, a notably higher prevalence than observed in the general population. Clinicians should be aware of this co-existence, and preoperative counseling should be an integral part of the care plan for affected individuals, where the potential risks and the available options for fertility preservation should be discussed in detail.
The Relationship between the Burden of Acromegaly, Associated Comorbidities, Complications and Disease Status
Authors: Elbaum Michał , Kałużny Marcin , Jawiarczyk-Przybyłowska Aleksandra , Wojtczak Beata , Zieliński Grzegorz , Bolanowski Marek
Published: October 2023

Uncontrolled acromegaly causes increased morbidity and mortality. The analysis of acromegaly comorbidities and complications is important when establishing a standard of care for the entire population of acromegaly patients. The aim of this study was to determine the frequency of comorbidities and complications of acromegaly and their dependence on the activity of the disease. A retrospective analysis of medical records from 124 patients with acromegaly was carried out, including 39 who were cured, 73 treated with somatostatin analogs and 12 newly diagnosed patients. The incidence of comorbidities and complications was very high, and those most frequently observed were arterial hypertension, multinodular goiter, lipid disorders, hypopituitarism and degenerative changes. At least one complication of acromegaly was observed in 92% of patients undergoing successful neurosurgery and in all pharmacologically treated patients. By contrast, two or more complications were observed in 77% of cured patients and in pharmacologically controlled and uncontrolled patients, 82% and 91%, respectively. Conclusions: Acromegaly is associated with a high prevalence of complications. Active acromegaly is associated with a higher incidence of complications than in treated groups. Untreated patients have more complications than treated patients. Successfully cured patients have significantly fewer complications than pharmacologically controlled patients and patients with active acromegaly.
Mesenchymal Stem Cell Therapy in Multiple Sclerosis: A Systematic Review and Meta-Analysis
Authors: Islam Md Asiful , Alam Sayeda Sadia , Kundu Shoumik , Ahmed Saleh , Sultana Shabiha , Patar Azim , Hossan Tareq
Published: October 2023

The assurance of safety and effectiveness is a significant focal point in all therapeutic approaches. Although mesenchymal stem cells (MSCs) have been identified as a potential novel therapeutic strategy for multiple sclerosis (MS), existing evidence regarding the effectiveness and safety of this strategy remains inconclusive. Thus, the primary aim of this systematic review and meta-analysis (SRMA) was to comprehensively assess the effectiveness and safety of MSC therapy in individuals diagnosed with MS. A comprehensive search was conducted using appropriate keywords in the PubMed, Scopus, Cochrane, ScienceDirect, and Google Scholar databases to determine the eligible studies. The change in the expanded disability status scale (EDSS) score from baseline to follow-up was used to assess MSC efficacy. The effectiveness of the therapy was assessed using a random-effects model, which calculated the combined prevalence and 95% confidence intervals (CIs) for MS patients who experienced improvement, stability, or worsening of their condition. The protocol was registered in PROSPERO (CRD42020209671). The findings indicate that 40.4% (95% CI: 30.6–50.2) of MS patients exhibited improvements following MSC therapy, 32.8% (95% CI: 25.5–40.1) remained stable, and 18.1% (95% CI: 12.0–24.2) experienced a worsening of their condition. Although no major complications were observed, headaches 57.6 [37.9–77.3] and fever 53.1 [20.7–85.4] were commonly reported as minor adverse events. All of the results reported in this meta-analysis are consistent and credible according to the sensitivity analyses. Regardless of different individual studies, our meta-analysis provides a comprehensive overview showing the potential of MSC therapy as a possible effective treatment strategy for patients with MS.
Inflammatory Markers as Predictors of Atrial Fibrillation Recurrence: Exploring the C-Reactive Protein to Albumin Ratio in Cryoablation Patients
Authors: Ozkan Eyup , Elcik Deniz , Barutcu Suleyman , Kelesoglu Saban , Alp Murat Erdem , Ozan Ramazan , Capar Gazi , Turkmen Omer , Cinier Goksel , Polat Veli , Inanc Mehmet Tugrul , Kepez Alper , Akgun Taylan
Published: October 2023

BACKGROUND: Atrial fibrillation (AF) is a common cardiac rhythm disorder associated with hemodynamic disruptions and thromboembolic events. While antiarrhythmic drugs are often recommended as the initial treatment, catheter ablation has emerged as a viable alternative. However, the recurrence of AF following ablation remains a challenge, and there is growing interest in exploring inflammatory markers as predictors of recurrence. METHODS: This retrospective, cross-sectional analysis included 249 patients who underwent cryoablation for paroxysmal AF. The relationship between the ‘C-reactive protein (CRP) to albumin ratio (CAR)’ and AF recurrence was examined. RESULTS: Two hundred and forty-nine patients with paroxysmal non-valvular atrial fibrillation were included. They were divided into two groups: those without recurrence (Group 1) and those with recurrence (Group 2). Significant differences were observed in age (57.2 ± 9.9 vs. 62.5 ± 8.4, p = 0.001) and left atrial size (4.0 ± 0.5 vs. 4.2 ± 0.7, p = 0.001) between the two groups. In blood parameters, significant differences were found in CRP (5.2 ± 1.3 vs. 9.4 ± 2.8, p < 0.001) and neutrophil counts (5.1 ± 2.2 vs. 6.7 ± 3.6, p = 0.001). In univariate regression analysis, age (OR: 1.058, CI: 1.024–1.093, p = 0.001), WBC count (OR: 1.201, CI: 1.092–1.322, p < 0.001), neutrophil count (OR: 1.239, CI: 1.114–1.378, p = 0.001), CAR (OR: 1.409, CI: 1.183–1.678, p < 0.001), and left atrial diameter (OR: 0.968, CI: 0.948–0.989, p = 0.002) showed significant associations with AF recurrence. CONCLUSIONS: Inflammation plays a crucial role in the initiation and progression of AF. This study demonstrated that along with age, the CAR can serve as an independent predictor of AF recurrence following cryoablation.
Effects of Non-Invasive Neuromodulation of the Vagus Nerve for the Management of Cluster Headache: A Systematic Review
Authors: Fernández-Hernando David , Justribó Manion Cristian , Pareja Juan A. , García-Esteo Francisco J. , Mesa-Jiménez Juan A.
Published: October 2023

Background: Cluster headache (CH) is a type of headache that has a global prevalence of 0.5–3/1000 people, provokes severe, strictly unilateral pain through the first branch of the trigeminal nerve, and is associated with observable autonomous responses. CH provokes intense pain and decreases quality of life. Objective: In this study, we aimed to carry out a systematic review of the effectiveness of non-invasive neuromodulation of the vagus nerve in patients with cluster headaches, which was registered on PROSPERO No. CRD42021265126. Methods: Six databases were used from their date of inception to February 2023 to obtain studies with the group intervention of non-invasive neuromodulation of the vagus nerve for cluster headache, with outcomes based on pain attacks, duration, and disabilities. Data on the subjects, group intervention, main outcomes, and results were collected by two authors. Results: The search provided 1003 articles, with three clinical trials being eligible for inclusion in the review. The methodological quality scores ranged from 6 to 8 points (mean: 7.3, SD: 0.8) out of a maximum of 10 points. The post-treatment results showed some positive effects using n-VNS as a treatment for cluster headache, more specifically regarding cervical neuromodulation of the vagus nerve. Conclusions: The systematic review found moderate-to-high-quality evidence supporting that n-VNS and cervical n-VNS may have some positive effects at the end of the treatment being effective to relieve the frequency and intensity of cluster headaches. The poor quantity of studies available and the lack of homogeneity in the study protocols did not allow the pooling of data for a meta-analysis.
Effectiveness of a Digital Health Application for the Treatment of Diabetes Type II—A Pilot Study
Authors: Bretschneider Maxi Pia , Roth Lena , Schwarz Peter E. H.
Published: October 2023

(1) Background: This study aimed at providing preliminary evidence for mebix, an app-based treatment program for patients with diabetes mellitus type II. The main target was to show a positive healthcare impact as defined by improved blood glucose control, i.e., reduced HbA1c values. (2) Methods: For this, a 3-month, prospective, open-label trial with an intraindividual control group was conducted. Participants received the mebix intervention for 3 months. HbA1c values were observed every 3 months: retrospectively, at baseline, and 3 months after the start of using the app. Additionally, weight and patients’ reported outcomes (well-being, diabetes-related distress, and self-management) were assessed. Data generated within the app were summarized and analyzed (steps, physical activity, fulfilled tasks, and food logs). (3) Results: After the usage of mebix for 3 months, participants significantly reduced their HbA1c levels (−1.0 ± 0.8%). Moreover, improvements in weight, well-being, and self-management as well as a reduction in diabetes-related distress were observed. App-generated data mainly supported the other main finding, that higher baseline HbA1c values lead to higher reductions. Overall, the study provided preliminary evidence that mebix can help patients improve metabolic and psychological health outcomes.
Primary Hyperparathyroidism in Older Adults: A Narrative Review of the Most Recent Literature on Epidemiology, Diagnosis and Management
Authors: Rizk Youssef , Saad Nour , Arnaout Wassim , Chalah Moussa A. , Farah Stephanie
Published: October 2023

Background: Primary hyperparathyroidism (PHPT) is a common endocrine disorder among older adults. The aim of this review is to shed light on PHPT, particularly in this age group, in terms of prevalence, clinical manifestations, medical and surgical management, and post-operative complications. Methods: Eligible studies were those considering PHPT exclusively in the older population (main databases: PubMed, Medline, Google Scholar and the University Online database). Articles published in the last 10 years (2013–2023) were considered. Eligibility criteria followed the SPIDER (sample, phenomenon of interest, design, evaluation, research type) tool. The methodological quality of the studies was assessed using the Joanna Briggs Institute critical appraisal tool. A total of 29 studies (mainly observational) matched the inclusion criteria. Results: The prevalence of PHPT is approximately 1 per 100 in the elderly, and it is more common in females. The clinical presentation varies by age and can include osteoporosis, fractures, and neuropsychiatric symptoms. Conservative management can be an option whenever surgery is not indicated or feasible. However, parathyroidectomy (PTX) remains a safe and effective modality in aging populations with improvement to symptoms, bone mineral density, fracture risk, frailty, quality of life, and metabolic derangements. Complication rates are similar in elderly people compared to younger ones, except for mildly longer length of hospital stay and reoperation for those with higher frailty. Conclusion: PHPT is a common yet overlooked and underdiagnosed condition among the older population. The safety and efficacy of PTX in the older population on different levels is now well demonstrated in the literature.
Possible New Histological Prognostic Index for Large B-Cell Lymphoma
Authors: Nitta Hideaki , Takizawa Haruko , Mitsumori Toru , Iizuka-Honma Hiroko , Araki Yoshihiko , Fujishiro Maki , Tomita Shigeki , Kishikawa Satsuki , Hashizume Akane , Sawada Tomohiro , Okubo Mitsuo , Sekiguchi Yasunobu , Ando Miki , Noguchi Masaaki
Published: October 2023

We conducted a retrospective analysis of GRP94 immunohistochemical (IHC) staining, an ER stress protein, on large B-cell lymphoma (LBCL) cells, intracellular p53, and 15 factors involved in the metabolism of the CHOP regimen: AKR1C3 (HO metabolism), CYP3A4 (CHOP metabolism), and HO efflux pumps (MDR1 and MRP1). The study subjects were 42 patients with LBCL at our hospital. The IHC staining used antibodies against the 17 factors. The odds ratios by logistic regression analysis used a dichotomous variable of CR and non-CR/relapse were statistically significant for MDR1, MRP1, and AKR1C3. The overall survival (OS) after R-CHOP was compared by the log-rank test. The four groups showed that Very good (5-year OS, 100%) consisted of four patients who showed negative IHC staining for both GRP94 and CYP3A4. Very poor (1-year OS, 0%) consisted of three patients who showed positive results in IHC for both GRP94 and CYP3A4. The remaining 35 patients comprised two subgroups: Good (5-year OS 60–80%): 15 patients who showed negative staining for both MDR1 and AKR1C3 and Poor (5-year OS, 10–20%): 20 patients who showed positive staining for either MDR, AKR1C3, MRP1, or p53. The Histological Prognostic Index (HPI) (the four groups: Very poor, Poor, Good, and Very good) is a breakthrough method for stratifying patients based on the factors involved in the development of treatment resistance.
Left Atrial Appendage Occlusion on a Beating Heart during Minimally Invasive Valve Surgery Using an Aortic Endoclamp: A Case Report
Authors: Suleiman Mathieu N. , Kaemmerer Ann-Sophie , Fechner Jörg , Nooh Ehab , Weyand Michael , Heim Christian
Published: October 2023

Concomitant LAA occlusion has been shown to be an effective and safe treatment for patients with atrial fibrillation during cardiac surgery to prevent embolic stroke. Minimally invasive procedures are challenging due to restricted access to and visibility of the surgical site. Also, aortic endoclamping has been developed as an alternative surgical approach to exoclamping. The aim of this article is to demonstrate the method of beating heart LAA occlusion with the Atriclip® (AtriCure, Mason, OH, USA) device during minimally invasive mitral valve surgery while using the endoclamping alternative for aortic cross-clamping.
Efficacy, Safety, and Subject Satisfaction of PrabotulinumtoxinA for Moderate-to-Severe Crow’s Feet: A Phase IV, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial
Authors: Lee Soo-Kyung , Kim Myoung Shin , Kwon Soon-Hyo , Chung Bo Young , Han Se Hee , Kim Hyoung Jun
Published: October 2023

PrabotulinumtoxinA has been identified as an effective agent against crow’s feet. Our study, which included Korean patients with moderate to severe crow’s feet, was undertaken to compare the efficacy and safety of PrabotulinumtoxinA and placebo treatments. Of the 90 study participants, 60 received prabotulinumtoxinA (24 U), whereas 30 received a placebo. The primary outcome assessment included facial wrinkle grading by investigators. At week 4, 69.64% of patients in the prabotulinumtoxinA group exhibited minimal crow’s feet severity; in contrast, a 0% improvement was observed in the placebo group (p < 0.0001). At week 12, the improvement rates were 30.36% for prabotulinumtoxinA and 6.90% for the placebo, demonstrating a significant difference (p = 0.0152). Based on the independent review panel’s assessment at week 4, the improvement rate was 39.29% in the prabotulinumtoxinA group and 3.45% in the placebo group during maximum smiling. Additionally, patient satisfaction was notably higher in the prabotulinumtoxinA group (32.14%) than in the placebo group (10.34%) at week 4 (p = 0.0289). Both treatments displayed comparable safety profiles, with only mild local reactions reported as ADRs for one patient from the prabotulinumtoxinA group. Thus, prabotulinumtoxinA demonstrates significant potential as a potent and safe remedy for crow’s feet.
Comparative Study of Male and Female Patients Undergoing Frozen Elephant Trunk Total Arch Replacement
Authors: Benk Julia , Berger Tim , Kondov Stoyan , D’Inka Matthias , Bork Magdalena , Walter Tim , Discher Philipp , Rylski Bartosz , Czerny Martin , Kreibich Maximilian
Published: October 2023

Background: Our aim was to investigate outcomes and long-term survival in male and female patients after frozen elephant trunk (FET) total arch replacement. Methods: Between March 2013 and January 2023, 362 patients underwent aortic arch replacement via the FET technique. We compared patient characteristics and intra- and postoperative data between male and female patients. Results: Male patients were significantly younger (p = 0.012) but revealed a higher incidence of coronary artery disease (p = 0.008) and preoperative dialysis (p = 0.017). More male patients presented with type A aortic dissections (p = 0.042) while more female patients had aortic aneurysms (p = 0.025). The aortic root was replaced in significantly more male patients (p = 0.013), resulting in significantly longer cardiopulmonary bypass duration (p < 0.001) and operative times (p < 0.001). There were no statistically significant differences in postoperative outcome parameters including in-hospital mortality (p = 0.346). However, new in-stent thrombus formation was significantly more frequent in female patients (p = 0.002). Age in years (odds ratio (OR): 1.026, p = 0.049), an acute pathology (OR: 1.941, p = 0.031) and preoperative dialyses (OR: 3.499, p = 0.010) were predictive for long-term mortality in our Cox regression model, sex (p = 0.466) was not. There was no statistical difference in overall survival (log rank: p = 0.425). Conclusions: Female patients are older but reveal fewer cardiovascular risk factors; aneurysms are more common in female than male patients. As female patients undergo concomitant surgical procedures less often, their operative times are shorter. While survival and outcomes were similar, female patients suffered from postoperative new in-stent thrombus formation significantly more often.
Computed Tomography versus Sleep Endoscopy (DISE) to Predict the Effectiveness of Mandibular Advancement Devices in Adult Patients with Obstructive Sleep Apnea: A Protocol for Systematic Review
Authors: Cebola Pedro , Caroça Cristina , Donato Helena , Campos Ana , Dias Sara Simões , Paço João , Manso Cristina
Published: October 2023

Obstructive sleep apnea is a sleep disorder with a high prevalence in the world population. The mandibular advancement device is one of the options for treating obstructive sleep apnea. Neck computed tomography and drug-induced sleep endoscopy are complementary diagnostic tests that may help predict the effectiveness of mandibular advancement devices. This study aims to analyze the best method for predicting the effectiveness of mandibular advancement devices in the therapeutic approach to obstructive sleep apnea. PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Web of Science Core Collection databases will be comprehensively searched. We will include randomized clinical trials, non-randomized prospective or retrospective clinical studies, case controls, cohort studies, and case series. Two authors will independently conduct data extraction and assess the literature quality of the studies. The analysis of the included literature will be conducted by Revman 5.3 software. The outcomes that will be analyzed are craniofacial characteristics, cephalometric assessments, site and type of obstruction of the upper airway, mean values of the apnea–hypopnea index, and SaO2 verified in the initial and follow-up polysomnography. This study will provide reliable, evidence-based support for the clinical application of mandibular advancement devices for obstructive sleep apnea.
Comparison of Maternal and Neonatal Outcomes between SARS-CoV-2 Variants: A Retrospective, Monocentric Study
Authors: Incognito Giosuè Giordano , Distefano Rosario Emanuele Carlo , Campo Giorgia , Gulino Ferdinando Antonio , Gulisano Chiara , Gullotta Chiara , Gullo Giuseppe , Cucinella Gaspare , Tuscano Attilio , Bruno Maria Teresa , Palumbo Marco
Published: October 2023

The impact of SARS-CoV-2 variants on maternal and neonatal outcomes during pregnancy is still poorly understood, and the emergence of different variants has further complicated our understanding of the virus’s effects. This retrospective, monocentric study aimed to fill this knowledge gap by analyzing the outcomes of pregnant women with acute SARS-CoV-2 infection caused by the Alpha, Delta, and Omicron variants. The study, conducted between December 2020 and March 2022 at San Marco Hospital, included 313 pregnant women with confirmed SARS-CoV-2 infection. The results showed that the Delta variant was associated with a significantly higher incidence of adverse outcomes, such as premature births, maternal intensive care unit admission, intrauterine growth restriction, and small for gestational age infants. Additionally, the Delta variant was linked to lower Apgar scores, higher maternal and fetal mortality rates, and increased levels of various biomarkers indicating more severe illness. Finally, the Delta variant also presented a greater possibility of vertical transmission. These findings underscore the complexity of understanding the impact of SARS-CoV-2 on pregnancy outcomes, especially considering the distinctive characteristics of different variants. By better understanding the specific impacts of each variant, appropriate preventive measures and management strategies can be implemented to optimize maternal and neonatal outcomes.
Does Restricted Ankle Joint Mobility Influence Hamstring Muscle Strength, Work and Power in Football Players after ACL Reconstruction and Non-Injured Players?
Authors: Oleksy Łukasz , Mika Anna , Kuchciak Maciej , Bril Grzegorz , Kielnar Renata , Adamska Olga , Wolański Paweł , Deszczyński Michał
Published: October 2023

This study was aimed at observing how the limitation of ankle dorsiflexion ROM affects hamstring muscle Peak Torque/BW (%), Average Power (W), and Total Work (J), and whether this effect is similar in football players after ACL rupture and reconstruction and in those without injuries. The study included 47 professional football players who were divided into two groups: Group 1 (n = 24) after ACL reconstruction and Group 2 (n = 23) without injuries in the past 3 years. Based on the Weight-Bearing Lunge Test (WBLT), the following subgroups in Groups 1 and 2 were distinguished: N (normal ankle joint dorsiflexion) and R (restricted ankle joint dorsiflexion). The concentric isokinetic test (10 knee flexions and extensions at 60°/s) was performed on both limbs. Significantly lower values of Peak Torque/BW and Average Power were observed in Group 1 compared to Group 2, as well as in subjects with normal and restricted ankle dorsiflexion. However, no significant differences were noted for either group in any of the strength variables comparing subjects with normal and restricted ankle dorsiflexion. A poor and non-significant correlation was exhibited between the ankle joint range of dorsiflexion and all the strength variables. The area under the ROC curve (AUC) for all the evaluated variables in both groups was below 0.5, or very close to this value, indicating that ankle dorsiflexion ROM has no diagnostic accuracy for hamstring muscle strength. Based on the obtained results, it can be assumed that ankle dorsiflexion limitation, which is common in football players, is not a factor in weakening hamstring muscle strength, either in football players after ACL reconstruction or among those without injuries. However, some authors have reported that limited mobility of the ankle joint can have a destructive effect on the work of the lower limbs and may also be a factor in increasing the risk of football injuries in this area. Therefore, we have suggested that hamstring muscle weakness and increased risk of injury may occur due to factors other than limited ankle mobility. These observations may be of great importance in the selection of prevention methods by including a broad spectrum of physical techniques, not just exercises that focus on the improvement of mobility or stability of the lower limbs.
Comparison of Diagnostic Validity of Cephalometric Analyses of the ANB Angle and Tau Angle for Assessment of the Sagittal Relationship of Jaw and Mandible
Authors: Kotuła Jacek , Kuc Anna , Szeląg Ewa , Babczyńska Alicja , Lis Joanna , Matys Jacek , Kawala Beata , Sarul Michał
Published: October 2023

Background: Cephalometric analysis is an essential tool used in orthodontic diagnosis and treatment planning. The aim of this study was to evaluate the reliability and repeatability of new cephalometric points introduced in Tau angle analysis, in contrast to the gold standard, which is the analysis of the ANB angle. For this purpose, an attempt was made to assess the repeatability and reliability of the introduction of anthropometric points by evaluating both inter- and intraobserver parameters, as well as the agreement among the orthodontists participating in the study. Methods: Repeatability and reliability assessments for all six anthropometric points (N, A, B, T, M, G) used in the analysis of the ANB and Tau angles were conducted individually by 29 orthodontists. This assessment was performed in triplicate on the day of the study, on the day following the first study, and on the seventh day after the second study. Measurement errors for the ANB and Tau angles were evaluated using the Dahlberg formula and intraclass correlation coefficients (ICCs). Results: The orthodontists in the study measured sagittal discrepancy significantly more accurately using the ANB angle compared to the Tau angle (p < 0.001). The Dahlberg error for measuring the Tau angle was three times greater than that for the ANB angle (p < 0.001). Additionally, the ICC for the Tau angle was more than 3.5 times smaller than that for the ANB angle, while the R&R error for Tau measurement was more than three times greater than that for the ANB angle (p < 0.001). Conclusions: The results of ANB angle measurements exhibit fewer errors in comparison to Tau angle measurements.
Mid-Term Electrical Remodeling after Percutaneous Atrial Septal Defect Closure with GCO Device in a Pediatric Population
Authors: Fumanelli Jennifer , Garibaldi Silvia , Castaldi Biagio , Di Candia Angela , Pizzuto Alessandra , Sirico Domenico , Cuman Magdalena , Mirizzi Gianluca , Marchese Pietro , Cantinotti Massimiliano , Piacenti Marcello , Assanta Nadia , Viacava Cecilia , Di Salvo Giovanni , Santoro Giuseppe
Published: October 2023

Background and aim: The GORE® CARDIOFORM (GCO) septal occluder is an atrial septal defect/patent foramen ovale closure device with theoretical advantages over other commercialized devices thanks to its softness and anatomical compliance. Our aim was to evaluate the short- and medium-term electrocardiographic changes after percutaneous ASD closure with GCO in a pediatric population. Methods: We enrolled 39 patients with isolated ASD submitted to trans-catheter closure from January 2020 to June 2021. ECG was performed before, at 24 h and 6 months after the procedure. P wave dispersion, QTc and QTc dispersion were calculated. ECG Holter was recorded at 6 months after implantation. Results: Patients’ age and body surface area (BSA) were 8.2 ± 4.2 years and 1.0 ± 0.3 m2 respectively. At the baseline, mean P wave dispersion was 40 ± 15 msec and decreased at 24 h (p < 0.002), without any further change at 6 months. At 24 h, PR conduction and QTc dispersion significantly improved (p = 0.018 and p < 0.02 respectively), while the absolute QTc value considerably improved after 6 months. During mid-term follow-up, QTc dispersion remained stable without a significant change in PR conduction. The baseline cardiac frequency was 88.6 ± 12.6 bpm, followed by a slight reduction at 24 h, with a further amelioration at 6 months after the procedure (87.3 ± 14.2, p = 0.9 and 81.0 ± 12.7, p = 0.009, respectively). After device deployment, two patients developed transient, self-limited junctional rhythm. One of them needed a short course of Flecainide for atrial ectopic tachycardia. No tachy/brady-arrhythmias were recorded at the 6-month follow-up. ASD closure resulted in a marked decrease in right heart volumes and diameters at 6 months after percutaneous closure. Conclusions: Percutaneous ASD closure with the GCO device results in significant, sudden improvement of intra-atrial, atrio-ventricular and intraventricular electrical homogeneity. This benefit persists unaltered over a medium-term follow-up. These electrical changes are associated with a documented positive right heart volumetric remodeling at mid-term follow-up.
Does Asthma Disrupt Psychological Wellbeing in Pregnancy?
Authors: Fernández-Paredes Paola C. , Morales Eva , Lopez-Soler Concepción , Garcia-Marcos Luis ,   on behalf of the NELA Study Group
Published: October 2023

(1) Background: Asthma is a very prevalent disease with special characteristics during pregnancy, however, little is known about its relationship to the psychological wellbeing of women in this period; we aimed to know whether depression and anxiety symptoms are more frequent in asthmatic pregnant women. (2) Methods: Family Apgar (week 20), Edinburgh Postnatal Depression Scale (weeks 20 and 32) and State-Trait Anxiety Inventory (STAI) (week 32) tests were administered to 738 pregnant women (81 asthmatics) in the Nutrition in Early Life and Asthma (NELA) birth cohort. (3) Results: There were no significant differences between asthmatic and non-asthmatic pregnant women in any of the different tests at any of the time points. The mean scores for the different tests and timepoints between asthmatic and non-asthmatic pregnant women were: Apgar 20, 17.9 ± 2.2 vs. 10.0 ± 2.2; Edinburgh 20, 6.7 ± 4.2 vs. 6.9 ± 4.3; Edinburgh 32, 5.9 ± 4.4 vs. 5.6 ± 4.3; and STAI 32, 16.7 ± 8.4 vs. 15.8 ± 8.3. The proportion of pregnant women out of the normal range score for any of the tests and time points was also similar in both populations. (4) Conclusions: asthma is not associated with the psychological wellbeing of pregnant women.
The Role of Adipose Tissue Mesenchymal Stem Cells in Colonic Anastomosis Healing in Inflammatory Bowel Disease: Experimental Study in Rats
Authors: Ntampakis Georgios , Pramateftakis Manousos-Georgios , Ioannidis Orestis , Bitsianis Stefanos , Christidis Panagiotis , Symeonidis Savvas , Koliakos Georgios , Karakota Maria , Bekiari Chrysanthi , Tsakona Anastasia , Cheva Angeliki , Aggelopoulos Stamatios
Published: October 2023

(1) Background: A surgical operation on an inflamed bowel is, diachronically, a challenge for the surgeon, especially for patients with inflammatory bowel disease. Adipose tissue-derived mesenchymal stromal cells are already in use in clinical settings for their anti-inflammatory properties. The rationale of the current study was to use AdMSCs in high-risk anastomoses to monitor if they attenuate inflammation and prevent anastomotic leak. (2) Methods: a total of 4 groups of rats were subjected to a surgical transection of the large intestine and primary anastomosis. In two groups, DSS 5% was administered for 7 days prior to the procedure, to induce acute intestinal inflammation. After the anastomosis, 5 × 106 autologous AdMSCs or an acellular solution was injected locally. Macroscopic evaluation, bursting pressure, hydroxyproline, and inflammatory cytokine expression were the parameters measured on the 8th post-operative day. (3) Results: Significantly less intra-abdominal complications, higher bursting pressures, and a decrease in pro-inflammatory markers were found in the groups that received AdMSCs. No difference in VEGF expression was observed on the 8th post-operative day. (4) Conclusions: AdMSCs attenuate inflammation in cases of acutely inflamed anastomosis.
Impact of Mechanical Removal on the Regeneration and Colonization Abilities of the Alien Aquatic Macrophyte Egeria densa
Authors: Thiébaut Gabrielle
Published: October 2023

The development of aquatic plant beds can obstruct boat traffic, hinder the practice of water activities, and impact the functioning of freshwaters. In order to mitigate their effects, mechanical removal is often the preferred management solution. The objective of this study was to test, in mesocosms, the effect of frequency (none, one, and two cuts) and cutting dates (May and/or July) on the regeneration and colonization capabilities of the aquatic plant Egeria densa, an invasive alien species in France. The cutting date had no effect on the capabilities of E. densa, but the two cuts significantly reduced the plant’s biomass. Removal produced numerous fragments, which exhibited very high survival and anchoring rates. However, summer removal produced fragments with lower regeneration and colonization abilities compared to fragments from spring cutting. Mechanical removal only temporarily reduced the biomass of the aquatic plant beds and could promote the formation of new beds from the fragments generated by management and dispersed by water flow.
Various Organ Damages in Rats with Fetal Growth Restriction and Their Slight Attenuation by Bifidobacterium breve Supplementation
Authors: Tsuji Masahiro , Tanaka Nao , Koike Hitomi , Sato Yoshiaki , Shimoyama Yoshie , Itoh Ayaka
Published: October 2023

Children with fetal growth restriction (FGR) and its resultant low birthweight (LBW) are at a higher risk of developing various health problems later in life, including renal diseases, metabolic syndrome, and sarcopenia. The mechanism through which LBW caused by intrauterine hypoperfusion leads to these health problems has not been properly investigated. Oral supplementation with probiotics is expected to reduce these risks in children. In the present study, rat pups born with FGR-LBW after mild intrauterine hypoperfusion were supplemented with either Bifidobacterium breve (B. breve) or a vehicle from postnatal day 1 (P1) to P21. Splanchnic organs and skeletal muscles were evaluated at six weeks of age. Compared with the sham group, the LBW-vehicle group presented significant changes as follows: overgrowth from infancy to childhood; lighter weight of the liver, kidneys, and gastrocnemius and plantaris muscles; reduced height of villi in the ileum; and increased depth of crypts in the jejunum. Some of these changes were milder in the LBW-B.breve group. In conclusion, this rat model could be useful for investigating the mechanisms of how FGR-LBW leads to future health problems and for developing interventions for these problems. Supplementation with B. breve in early life may modestly attenuate these problems.
How Did Journals in Water Sciences Survive the COVID-19 Pandemic? A Scientometric Study
Authors: Rzymski Piotr
Published: October 2023

The COVID-19 pandemic affected nearly all strata of life, including scientific activities. Implementation of nationwide lockdowns, closures of universities, and other measures significantly limiting social mobility precluded field and laboratory research from being pursued at a pre-pandemic pace. On the other hand, working from home could translate into higher productivity of researchers in terms of publication output, ultimately affecting the journals’ metrics. This effect has been well evidenced in the biomedical field, but whether it also occurred in aquatic sciences has not been explored. Therefore, this study aimed to analyze and compare various metrics of journals classified in the Scopus evaluations in 2019 (encompassing 2016–2019, the pre-pandemic period) and 2022 (covering 2019–2022, the pandemic period) within three subjects: aquatic science, oceanography, and water science and technology. In general, the number of journals classified into the considered categories increased in 2022 by 12%, and the majority (78%) experienced an increase in the CiteScore metric. The total published articles and received citations also significantly increased in 2022 by 17.5% and 63.5%, respectively, and were even higher in the case of open access journals—69% and 145%, respectively. The overall share of cited articles in the considered period was higher by 5% than in the 2019 Scopus evaluation and by 7% in the case of open access periodicals. However, source normalized impact per paper (SNIP) and the SCImago journal rank (SJR) values decreased by 7% and 8%, respectively. The highest share of citations was generated by Water Research, Water, and the Journal of Hydrology, and the highest number of articles was published by Water, Frontiers in Marine Science, and Desalination and Water Treatment. Only five of the COVID-19-related papers published in journals with the highest CiteScore and total number of citations received more than 200 citations, but their contribution to citations received by the journals was not high. In summary, the present study’s findings indicate the high potential of the field dedicated to water sciences to adapt in a period challenged by an infectious disease pandemic. However, they do not exclude the adverse effect that this period could have on the activities of individual scientists and research teams.
Use of Printed Sensors to Measure Strain in Rolling Bearings under Isolated Boundary Conditions
Authors: Bartz Marcel , Häußler Felix , Halmos Fabian , Ankenbrand Markus , Jüttner Michael , Roudenko Jewgeni , Wirsching Sven , Reichenberger Marcus , Franke Jörg , Wartzack Sandro
Published: October 2023

The knowledge of the operating conditions in rolling bearings in technical applications offers many advantages, for example, to ensure a safe operation and to save resources and costs with the help of condition monitoring and predictive maintenance procedures. In many cases, it is difficult to implement sensors to measure the operating conditions of the rolling bearing, for reasons such as inaccessibility of the mounting position or non-compliance with installation space neutrality, which influences the sensor on the measuring point. Printed sensors using a digital deposition process, which can be used in very narrow design spaces, offer advantages in this respect. So far, these sensors have not been established in rolling bearings, so there is potential for technical application. This paper discusses the fundamental advantages and disadvantages as well as the challenges of the application, and it demonstrates the feasibility under isolated boundary conditions by applying a printed strain gauge sensor to the outer ring of a cylindrical roller bearing NU210 in an experimental setup to measure the strain under load. In this setup, the outer ring is deformed by 2 mm under an increasing radial load using a hydraulic press, and the strain is measured. Both a commercial reference sensor and a FE-simulation are used to validate the measurement. The results show that an implementation using printed sensors as a strain gauge works successfully. The resulting challenges, such as measuring strain gradients and printing on curved surfaces, are finally evaluated, and an outlook for further work is given.
Energy Consumption Analysis and Efficiency Enhancement in Manufacturing Companies Using Decision Support Method for Dynamic Production Planning (DSM DPP) for Solar PV Integration
Authors: Skėrė Simona , Bastida-Molina Paula , Hurtado-Pérez Elías , Juzėnas Kazimieras
Published: October 2023

The Industrial Revolution brought major technological progress and the growth of manufacturing, which resulted in significant changes in energy use. However, it also brought about new environmental issues such as increased energy needs, unstable electricity costs, and worsened greenhouse gas effects. Nowadays, it is crucial to analyze energy use to stay competitive. Manufacturers, highly dependent on electricity, can save energy and enhance efficiency by improving production methods. This article presents the findings of a research study conducted on a Lithuanian manufacturing company, aiming to investigate its electricity consumption over a 15-month period from 2022.01 to 2023.03—detailed data about the monthly consumption of the six most powerful machines and their active and standby hours are presented. The total electricity consumption of those matched 173.62 MWh. Employing the Decision Support Method for Dynamic Production Planning (DSM DPP), which was previously developed and refined, the study examines the potential for time savings and, subsequently, energy savings, through process reorganization. A detailed three-month production orders observation period demonstrates tangible time savings while using the proposed DSM DPP—time savings of approximately 5% can be achieved. Compared to that, production might achieve a 20% productivity increase with advanced technology implementation, so 5% is a great result for an easily adaptable method. Based on this, changes in energy consumption and CO2 emissions due to electricity consumption are calculated and presented knowing that the company uses energy from the grid. Adaptation of the replanning method resulted in a reduction of electricity use by 175 kWh and a reduction of CO2 consumption by 27 kgCO2. With proper production planning, energy and CO2 consumption can be decreased, which is a high priority in today’s world.
Holistic Approach Promotes Failure Prevention of Smart Mining Machines Based on Bayesian Networks
Authors: Martinsen Madeleine , Fentaye Amare Desalegn , Dahlquist Erik , Zhou Yuanye
Published: October 2023

In the forthcoming era of fully autonomous mining, spanning from drilling operations to port logistics, novel approaches will be essential to pre-empt hazardous situations in the absence of human intervention. The progression towards complete autonomy in mining operations must have meticulous approaches and uncompromised security. By ensuring a secure transition, the mining industry can navigate the transformative shift towards autonomy while upholding the highest standards of safety and operational reliability. Experiments involving autonomous pathways for mining machinery that utilize AI for route optimization demonstrate a higher speed capacity than manually operated approaches; this translates to enhanced productivity, subsequently fostering increased production capacity to meet the rising demand for metals. Nonetheless, accelerated wear on crucial elements like tires, brakes, and bearings on mining machines has been observed. Autonomous mining processes will require smarter machines without humans that guide and support actions prior to a hazardous situation occurring. This paper will delve into a comprehensive perspective on the safety of autonomous mining machines by using Bayesian networks (BN) to detect possible hazard fires. The BN is tuned with a combination of empirical field data and laboratory data. Various faults have been recognized, and their correlation with the measurements has been established.
Selecting and Weighting Mechanisms in Stock Portfolio Design Based on Clustering Algorithm and Price Movement Analysis
Authors: Purwandari Titi , Riaman  , Hidayat Yuyun , Sukono  , Ibrahim Riza Andrian , Hidayana Rizki Apriva
Published: October 2023

The fundamental stages in designing a stock portfolio are each stock’s selection and capital weighting. Selection and weighting must be conducted through diversification and price movement analysis to maximize profits and minimize losses. The problem is how the technical implementations of both are carried out. Based on this problem, this study aims to design these selection and weighting mechanisms. Stock selection is based on clusters and price movement trends. The optimal stock clusters are formed using the K-Means algorithm, and price movement analyses are carried out using the moving average indicator. The selected stocks are those whose prices have increasing trends with the most significant Sharpe ratio in each cluster. Then, the capital weighting for each preferred stock is carried out using the mean-variance model with transaction cost and income tax. After designing the mechanism, it is applied to Indonesia’s 80 index stock data. In addition, a comparison is conducted between the estimated portfolio return and the actual one day ahead. Finally, the sensitivity of investors’ courage in taking risks to their profits and losses is also analyzed. This research is expected to assist investors in diversification and price movement analysis of the stocks in the portfolios they form.
Estimation of Pianka Overlapping Coefficient for Two Exponential Distributions
Authors: Alhihi Suad , Almheidat Maalee
Published: October 2023

Overlapping coefficients (OVL) are commonly used to estimate the similarity between populations in terms of their density functions. In this paper, we consider Pianka’s overlap coefficient for two exponential populations. The methods for statistical inference of Pianka’s coefficient are presented. The bias and mean square error (MSE) of the maximum likelihood estimator (MLE) and the Bayes estimator of Pianka’s overlap coefficient are investigated by simulation. Confidence intervals for Pianka’s overlap measure are constructed.
Supported MOCVD TiO2 Thin Films Grown on Modified Stainless Steel Mesh for Sensing Applications
Authors: El Habra Naida , Visentin Francesca , Russo Francesca , Galenda Alessandro , Famengo Alessia , Rancan Marzio , Losurdo Maria , Armelao Lidia
Published: October 2023

Among semiconductor metal oxides, that are an important class of sensing materials, titanium dioxide (TiO2) thin films are widely employed as sensors because of their high chemical and mechanical stability in harsh environments, non-toxicity, eco-compatibility, and photocatalytic properties. TiO2-based chemical oxygen demand (COD) sensors exploit the photocatalytic properties of TiO2 in inducing the oxidation of organic compounds to CO2. In this work, we discuss nanostructured TiO2 thin films grown via low-pressure metal organic chemical vapor deposition (MOCVD) on metallic AISI 316 mesh. To increase the surface sensing area, different inorganic acid-based chemical etching protocols have been developed, determining the optimal experimental conditions for adequate substrate roughness. Both chemically etched pristine meshes and the MOCVD-coated ones have been studied by scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray (EDX) microanalysis, and X-ray photoelectron spectroscopy (XPS). We demonstrate that etching by HCl/H2SO4 at 55 °C provides the most suitable surface morphology. To investigate the behavior of the developed high surface area TiO2 thin films as COD sensors, photocatalytic degradation of functional model pollutants based on ISO 10678:2010 has been tested, showing for the best performing acid-etched mesh coated with polycrystalline TiO2 an increase of 60% in activity, and degrading 66 µmol of MB per square meter per hour.