bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting Pathogenic Missense Mutations in the Human c-MET Oncogene Using a Nucleotide Scoring Functio
Authors: Prashantha Karunakar  , Padmini Arunkumar  , Kumar Sankaran  , Shivangi Naik
Published: April 2023

Background: Many nucleotide variations in the human genome remain uncharacterized even more than ten years after the first draft was published. Objective: A three-parameter nucleotide-based scoring function was designed to predict the possible pathogenicity of 163 uncharacterized but validated missense mutations of the c-MET oncogene. Methodology: The parameters used by the scoring function were: surrounding consensus regions in a multiple sequence alignment of the human c-MET oncogene and five orthologous variants, inter-species allele frequency of each human missense mutation, and the nature of the mutation. Results: Out of 163 variants of unknown significance, 99 and 52 mutations were characterized as likely pathogenic and pathogenic respectively. An analysis of nine variants of known significance revealed that this scoring function could classify six out of nine (66.67%) variants with a reasonable accuracy.
Thin layer chromatographic analysis of extracted Fructooligosaccharides from organic waste
Authors: Praveen Kumar Gupta  , Sachi Mehra  , Vandana T  , Anwesha Sinha  , Kandi Arvind Reddy  , Lingayya Hiremath
Published: April 2023

Nutraceuticals and functional foods are increasing in popularity in the recent years. Fructooligosaccharides (FOS) has emerged as functional food ingredient in market and is very well known for its prebiotic properties. Hence, there is a growing need for extensive research on usage and extraction of Fructooligosaccharides. In this study, organic wastes namely onion waste and spoilt wheat have been explored for its potential use in extraction of FOS. The extraction was done using ethanol and optimization was done by considering different initial raw material weights. Thin Layer Chromatography (TLC) confirmed the presence of FOS in the extracts.
Documentation of pollution status, ecological state and fishing activity in the Lakes of Bangalore
Authors: P. Arya Alok  , Sushree Sangita Mohapatra
Published: April 2023

The documentation and investigative study are based on the pollution status, ecological state and fishing activity in surveyed Lakes of Bangalore. The 14 Lakes form different series of Bangalore were documented. The pollution status of these Lakes was categorized into 5 divisions like highly polluted, polluted, eutrophicated, restored and under restoration process. The physico-chemical parameters like BOD, COD, DO, pH, temperature and turbidity were analysed. Fishing activity signifies the socio-economic status of localities which is threatened due to heavy pollution. The avi- faunal diversity was also observed in the lake area, which basically shows the ecological state of those. The anthropogenic activity aroused by urbanization and industrialization is the main cause of pollution and which ultimately causes the loss of biodiversity.
Actualización en el abordaje y tratamiento del paciente con osteoporosis
Authors: Antolín-López Blanca Esthela , Aguilera-Duarte Luis José
Published: April 2023

El Consenso de los Institutos Nacionales de Salud (NIH) de los Estados Unidos, llevado a cabo en 2001, definió a la osteoporosis como una enfermedad esquelética, caracterizada por disminución de la resistencia ósea y deterioro de su microarquitectura; la cual predispone a los pacientes aun mayor riesgo de fractura.
pensamiento crítico en el estudio de la pobreza
Authors: Benegas Mateo María José , García-Castilla Francisco Javier
Published: April 2023

El propósito de este artículo es instar al investigador o hacedor de política pública a una reflexión necesaria antes de enfrentarse al análisis de la pobreza: ninguna apreciación posible de este fenómeno es una cuestión neutral. Los elementos simbólicos, ideológicos y paradigmáticos estructuran la concepción de la pobreza, no sin consecuencias prácticas.
Los conceptos adoptados no sólo definen el fenómeno, sino que guían su análisis y medición, así como las intervenciones de política para enfrentarlo. Por lo que, a su vez, crean una realidad material que retroalimenta las representaciones sociales sobre la pobreza y la actitud de la Administración y de la Sociedad hacia la misma. Así visto, el concepto de pobreza es un constructo social resultante de un contexto histórico determinado, a la par que un constructor de materialidad.
En las últimas décadas, los consensos sobre la pobreza han mudado de concepciones puramente economicistas a enfoques más integrales, multidimensionales y multidisciplinarios.
ÜNİVERSİTE ÖĞRENCİLERİNİN KAYMAKAMLIK MESLEĞİ ALGISI
Authors: ÇAPAR Selim , KOCA Mehmet
Published: April 2023

Özet
Türkiye’de devletin toprak üzerindeki yapılanması ve yönetimi mülki idare sistemine dayanmaktadır. Tarihsel süreç içerisinde sosyoekonomik, değişimlerden dolayı değişime uğrayan mülki idare sistemi kendisini devamlı bir şekilde güncellemiş ve günümüzdeki halini almıştır. Sistemin merkezinde yer alan mülki idare amirleri güvenlikten, sosyal yardıma ve eğitime kadar il ve ilçe düzeyinde farklı alanlarda koordinasyonun sağlanması ve gelişmelerin kaydedilmesi için kritik ve stratejik bir fonksiyon üstlenmekte olup, ülkenin mülki yapılanmasının yönetilmesinde stratejik insan kaynağını ve unsurunu oluşturmaktadır. Bu kapsamda mesleğin ilk aşamasını oluşturan kaymakamlık mesleğinin gerek toplum nezdinde gerekse de üniversite öğrencileri arasında algısının tespit edilmesinin, eğilimlerin belirlenmesi açısından önemli olduğu düşünülmektedir. Geçmişte ve günümüzde yapılan çalışmalar ışığında mülki idare amirlerinin toplum nezdinde statü ve saygınlığının oldukça yüksek olduğu ve tercih edilen bir meslek olduğu görülmüştür. Özellikle üniversite öğrencilerine yönelik bu araştırmada ilgili sorulara verilen yanıtların %90’lar üzerinde seyrettiği görülmektedir. Yapılan çalışmalar doğrultusunda bir mülki idare amirinin taşıması gereken en önemli özelliklerin tarafsızlık ve dürüstlük, halka yakınlık, yerelin sorunlarına vakıf olma gibi özellikler olduğu müşahede edilmiştir. Bununla birlikte kaymakam adaylarının seçimi aşamasında nesnel ölçütlere göre seçim yapılmadığına ve siyasal etmenler gibi durumların nesnelliği bozduğuna yönelik genel bir kaygının olduğu tespit edilmiştir. Bu bulgunun önceki araştırmalara da yansıdığı ve varlığını sürdürdüğü ifade edilebilir.
KÜLTÜR VE MODERNLEŞME ARACI OLARAK HALKEVLERİNİN HALK EĞİTİMİ FAALİYETLERİ
Authors: YENİSOY ÖZKAN Nilgün
Published: April 2023

Türk Kurtuluş Savaşı başarıyla neticelendikten sonra Türk milletini çağdaş medeniyetler düzeyine ulaştırabilmek için inkılaplar yapılmıştır. Bu inkılaplar sosyal, siyasi kültürel ve hukuki olarak değişim ve yenileşmelerin temelini oluşturmuştur. İnkılaplar ile birlikte Türk milleti dar kalıplardan kurtularak milli benliğini bulmuş ve bu istikamette yol almıştır. İnkılapların tüm halk tabanına yayılabilmesi için eğitim kurumlarına ihtiyaç duyulmuştur. Halkın hızlı bir şekilde eğitilmesi için mevcut eğitim kurumlarının yetersiz olduğu görülmüştür. Fakat örgün eğitim dışında kalan halk kitlelerinin eğitilmesi önemli bir problem olarak görülüyordu. Türkiye’de halk eğitimi ile ilgili çalışmalara ilk olarak Türk Ocakları’nda başlanmıştır. Osmanlı Devleti döneminde kurulan Türk Ocakları, Anadolu’da halk eğitimi konusunda büyük görevler üstlenmiştir. Türk Ocakları Türkiye Cumhuriyeti Devleti kurulduktan sonra da bir süre daha varlığını sürdürmüştür. Bu kurumun 1931 yılında kendini feshetmesinden sonra halk eğitimi görevi Halkevleri tarafından üstlenilmiştir. Atatürk’ün en önemli projelerinden biri olan halkevleri 19 Şubat 1932 tarihinde kurulmuştur. Atatürk’ün halkçılık ilkesi doğrultusunda Türk milletinin yapılan ve yapılacak olan inkılapları daha iyi bir şekilde özümsemeleri ve Türk modernleşmesinin gerçekleştirilmesi için halkevleri önemli çalışmalar yürütmüştür. Bu çalışmada halkevlerinin halk eğitimi hususunda kendi bünyesindeki çalışma kolları ile yürüttüğü faaliyet üzerinde durulacaktır.
GALİP ERDEM’İN HAYATI VE KİŞİLİĞİ (1930-1997)
Authors: YALÇIN A. Kutalmış
Published: April 2023

Bu çalışmada Türk basın-yayın ve siyasi hayatında milliyetçi ve muhafazakar kimliğiyle öne çıkan çok önemli bir gazeteci ve yazar, deneyimli bir bürokrat ve aynı zamanda bir avukat olan Galip Erdem’in hayatı ve kişiliği incelenmiştir. Galip Erdem basın-yayın hayatı boyunca yazı işleri müdürlüğü, yazarlık ve genel yayın yönetmenliği gibi çok aktif görevlerde bulunmuştur. Galip Erdem bu görevlerini Türk Yurdu, Orkun, Tercüman, Son Havadis, Yeni İstanbul, Bizim Anadolu, Zafer, Bab-ı Alide Sabah, Ortadoğu, Ölçü, Devlet, Bozkurt, Yeni Sözcü, Bakış, Töre ve Millî Hareket isimli dönemin milliyetçi ve muhafazakar görüşte olan dergi ve gazetelerinde sürdürmüştür. Kendisi bu faaliyetleri devam ederken başta Hüseyin Nihal Atsız, Dündar Taşer, Prof. Dr. Osman Turan, Osman Yüksel Serdengeçti ve Emine Işınsu olmak üzere pek çok akademisyen, sanatçı, yazar ve bilim insanıyla birlikte çalışma fırsatı bulmuştur. Çok üretken bir yazar olarak dikkat çeken Galip Erdem’in, sadece Devlet’te 340 makalesi yayınlanarak en fazla makalesi yayınlanan yazar unvanına sahip olmuştur. Kerkük Türklüğüne ise özel bir önem atfeden Galip Erdem, Irak Türkmenlerini devamlı surette Anadolu’nun bir parçası olarak görmüştür. Galip Erdem siyasi yaşamı esnasında ise Samsun, Burdur ve Niğde illerinden 1965, 1969 ve 1973 yıllarında yapılan genel seçimlerde milletvekili adayı olmuştur. Kendisi aynı zamanda 12 Eylül 1980 Darbesi’nden sonra görülen MHP ve Ülkücü Kuruluşlar Davası’nın avukatlarındandır.
Design Concepts for Peel-Dominant Adhesive Joints in Aeronautic Applications
Authors: Lopes J.P.M. , Campilho R.D.S.G. , Bellali M.A. , Baghdadi M.C.
Published: April 2023

The adhesive bonding technique is employed from the aeronautical/aerospace industry to current house products. To comply with the requirements of distinct applications, different joint configurations are available to the designer. While single-lap joints (SLJ) are the most common in application and research, double-lap joints, scarf joints and T-joints find specific applications. T-joints are seldom studied in the literature, but these are used, for instance, in aircraft to bond the stiffener beams to the skin, or in the cars between the B-pillar and the rocker. Due to the high stress concentrations, T-joints often fail under average stresses much lower than the adhesive strengths, giving rise to the necessity for proper design and strength improvement methodologies. This work initially aims to validate the cohesive zone modelling (CZM) technique with experiments, and then use it to numerically evaluate and optimize the performance of T-joints subjected to peel loads. CZM is nowadays regarded as the most powerful strength prediction tool for adhesive joints, and can be a valuable tool to improve T-joints. Different features are addressed for a complete analysis: adhesive type, geometrical parameters, dual-adhesive technique for strength improvement, and composite joints. The evaluated geometrical parameters are the base adherend thickness (a), T-part thickness (t), overlap or bonding length (l) and curvature radius (r). As a result of this work, the model was successfully validated, and clear design guidelines were provided to define the ideal geometric and material (adhesive) conditions for best performance.
Epistemological Approach to Knowledge Sharing Issues at Universities in the COVID-19 Pandemic: Altruism and Social Exchange Theory Context
Authors: Michalová Tereza , Maršíková Kateřina
Published: April 2023

Professionals and researchers in the literature widely discuss the concept of knowledge sharing. This article aims to provide a theoretical framework for knowledge sharing from the perspective of selected factors such as altruism and social exchange theory (SET) and also discusses an epistemological approach to knowledge management and knowledge sharing. The main aim of this paper is to theoretically and empirically contribute to knowledge sharing in the University context. The paper also discusses the altruism and knowledge sharing of students as individuals who may expect some recognition for sharing their tacit and explicit knowledge. Data confirm that there is often an altruistic approach among students. If they expect recognition, it is mainly on a group level. Groups of student respondents also gave a unique perspective on the influence of the COVID-19 Pandemic on the attitude toward sharing knowledge.
Technology, Virtue and the Good Life: Between Production and Consumption
Authors: Mardosas Egidijus
Published: April 2023

This paper explores recent developments in the virtue ethics approach to human flourishing in technological societies. I discuss the merits of virtue ethics in a broader context of various philosophies of technology. I propose that a distinction can be made between two broad approaches to the question of the good life and technology: the production approach that focuses on the roles technologies could and do play in production for the elimination of various forms of labour and the consumption approach that focuses on the role of technology in everyday social settings and interactions outside the workplace. Finding that the virtue ethics approach currently remains almost exclusively focused on consumption, I conclude the article with a suggestion for how virtue theory can be advanced beyond consumption using the resources of the same virtue ethics tradition.
Metaphysics of Cognitive Processes in the Formation of Media Reality
Authors: Chornomordenko Ivan , Rubanets Oleksandra
Published: April 2023

The article deals with the metaphysics of cognitive processes in media reality formation. Metaphysics reveals being and nothingness. Processes and discourse practices are regarded as cognitive processes. There is a distinction between media reality, hyper reality and virtual reality. The relationship between reality and information processes is being explored. The metaphysics of media-reality influences the existence of man and society, touches upon the value foundations of being and introduces the way to transform them. The metaphysical dimension of cognitive processes opens up new forms of media reality impact on society. It is considered to be an integrative form uniting the representatives of different groups in achieving a specific goal.
Subjectivity of Discourse from the Philosophic Perspective
Authors: Peng Bingzhuan
Published: April 2023

Language not only objectively expresses the thought of a proposition but also indicates the speaker’s emotion, attitude, and viewpoints toward a proposition, which is called subjectivity in the study. Subjectivity is one of the main topics in philosophy. However, the phenomenon of subjectivity is mainly discussed at the word, construction, or syntactic level from the perspective of linguistics. To better the characteristics of speakers as subjects in social practice activities and cognitive activities, an analytical framework of subjectivity in discourse from the perspective of philosophy was constructed to investigate subjectivity at the discourse level. Three aspects, that is, experience, mental and communicative models, were explored. The results show that (1) the constructed analytical framework clearly shows the social characteristics of subjectivity in discourse; (2) the experience model is divided into the speaker’s social and cultural experience; (3) the mental model is construed as the speaker’s mental cognition, reflected by the speaker’s mental stance and emotion; (4) the communicative model is represented by the speaker’s communicative intention and communicative practice, including appeal, command and announcement. The study provides an analytical framework to dig up the subjective nature of language and the relationship among speakers, society and discourse. This study also enriches the research on subjectivity and discourse analysis.
Sigismund Augustus’ Tapestries at the Residence of the Grand Duke of Lithuania and King of Poland in the Lower Castle Palace in Vilnius
Authors: Kuizinienė Ieva
Published: April 2023

This article presents an analysis of the stages and specifics encountered during scholarly research on the chosen theme, stating that separate stages in the research were determined according to different aims, research methods, and approaches. The research was conducted under circumstances characterised by a lack of sources and the fragmented nature of the information, which meant that as the research went on for 150 years, scholars generally relied on a solitary known source: the panegyric by Stanisław Orzechowski written on the occasion of the wedding of Sigismund Augustus, Grand Duke of Lithuania and King of Poland, and Catherine Habsburg at Wawel Royal Castle in 1553, in which he described the tapestries used to decorate the palace for the event. As a subsequence of this, for the rest of the mentioned period, no reference was made in scientific publications to the connection between Sigismund Augustus’ tapestries and Vilnius or to the Vilnius Lower Castle, which had been the ruler’s most important residence for a long time. In this article, based on sources and the most recently discovered artefacts, evidence is provided that Sigismund Augustus began collecting tapestries whilst he was still only the grand duke of Lithuania and that his earliest commissions were made in Vilnius. This is irrefutably evident from a document dated 14 January 1547 in Sigismund Augustus’ accounts for the period of 1546–1548, recorded by the young ruler’s treasurer Jan Lutomirski at the Vilnius palace. There is no doubt that the ‘pictures’ – Creation of the World and The Story of Noah – mentioned among the expenses were the first sketches for the upcoming series of biblical textiles created by Michiel Coxcie. Nonetheless, the most important evidence is the heraldic tapestry acquired by the National Museum – Palace of the Grand Dukes of Lithuania in 2009. Woven before 1548, it features the combined coat of arms of Sigismund Augustus, the Grand Duke of Lithuania, with the great crown of the Lithuanian grand duke above it. The same combined coat of arms of Sigismund Augustus was minted on Lithuanian coins during his reign and was also used on the great seal of the state of the Grand Duchy of Lithuania.

In summary, it can be stated that Sigismund Augustus owned tapestry series in Vilnius from as early as 1543. This was where the famous series The Story of the First Fathers and The Story of Noah were commissioned. The Lithuanian court treasury accounts attest that between 1545 and 1561, tapestries were often displayed at the Vilnius palace, the main residence in the Grand Duchy of Lithuania, and were taken with the ruler when he travelled to his other residences in Trakai, Rūdninkai, Skierniewice, or Rawa.
Curriculum of the State Music School (1923): Trajectories and Possible Origins of the Institutionalisation of Musical Education
Authors: Sapiega Gabrielius Simas
Published: April 2023

The article aims to summarise the curricula of Juozas Naujalis’s private music school, nationalised in 1920, later the State Music School, and their possible origins in the historical context of music education in Lithuania in the second half of the nineteenth–the early twentieth century. Although the circumstances of the founding of the State Music School have been investigated, some pages of its history still remain obscure. The relevance of this article is determined by the currently changing educational programmes in Lithuania and by the trends of the creation and transformation of the State Music School Conservatory in the light of educational programmes. The article presents in detail the first musical education programme prepared by the State Music School in 1923, the Law on the Music School adopted in 1921, and the consistent integration of music subjects into the educational process from 1920 to 1930. The purpose of the article is to show the first steps of the State School of Music towards its transformation into a conservatory taking into account musical education programmes and the reintegration of musical educational experience. Source analysis, historical comparative, and analytical-critical methods were used.
A educação e o pertencimento cooperativista: um estudo de caso na Cooperativa Sicredi Fronteira/MS realizado em 2012
Authors: Martins Romildo Camargo , Da Costa Reginaldo Brito , Constantino Michel , Rodrigues Divino de Jesus da Silva , De Araújo Rildo Vieira , Bertuzzi Felipe Buller , Nogueira Micaella Lima , Correia Jonas Benevides
Published: April 2023

Neste estudo é abordado a necessidade da educação cooperativista e sua importância para a organização local. Para tal, o estudo buscou compilar elementos que ratifiquem esta afirmação, levando em conta o grau de importância das cooperativas de crédito no contexto socioeconômico do município de Ponta Porã/MS e do Brasil. Sendo assim, o presente artigo foi desenvolvido a partir da pesquisa blibliográfica e da análise dos dados informacionais coletados mediante a aplicação de questionários com os colaboradores e cooperados. Dentre os principais resultados observados, verificou-se que uma parcela considerável dos cooperados desconhecem seus direitos e deveres como associados, o que pode contribuir para outro comportamento identificado: o elevado número de ausências destes nas assembleias geral e ordinária.
Ensino da gestão ambiental na formação do administrador: um estudo de caso
Authors: Martins Romildo Camargo , Da Costa Reginaldo Brito , Constantino Michel , De Araújo Rafael Vieira , De Araújo Rildo Vieira , Bertuzzi Felipe Buller , Nogueira Micaella Lima , Correia Jonas Benevides
Published: April 2023

Este estudo tem como objetivo principal evidenciar as particularidades da importância de disciplinas da Gestão Ambiental na formação acadêmica dos futuros administradores de empresas. Para isso, é analisada a relação de temas como Gestão Ambiental, Educação Ambiental, Sustentabilidade e Desenvolvimento Local Integrado e Sustentável com o fortalecimento da conduta ambiental frente a atividade do Administrador de Empresas enquanto promotor de desenvolvimento local em manutenção da atividade voltada à subsistência econômica. A metodologia está baseada em consultas bibliográficas e pesquisa de campo, de natureza qualitativa e quantitativa, onde a coleta de dados foi realizada por meio da utilização de questionários aplicados na Universidade Estadual de Mato Grosso do Sul. Se propõe evidenciar a importância educacional de disciplinas voltadas à Gestão Ambiental na formação ética, profissional e ambiental dos futuros gestores. Objetiva-se identificar a importância da Gestão Ambiental como disciplina na grade curricular do curso, além de analisar a necessidade da aplicabilidade da disciplina como fator de redução de danos ao meio ambiente. Além disso, busca-se verificar se há evidência da abordagem deste conteúdo na formação acadêmica, analisar o conhecimento de conceitos básicos relacionados à Gestão Ambiental e, por fim, verificar a preocupação ética frente à questão ambiental. Percebe-se a necessidade de aprofundamento as questões relacionadas ao meio ambiente e seus recursos naturais, necessários ao desenvolvimento de atividades empreendedoras. Neste contexto, coexiste a importância fundamental do ambiente acadêmico como provedor de conhecimentos em um processo de ensino-aprendizagem entre os agentes envolvidos.
Variable Anatomical Presentation of Testicular Veins: A Cross-sectional Study
Authors: Daripelli Sushma , Motwani Rohini , Rout Shipra , Chandrupatla Mrudula , Bhavani T
Published: April 2023

Introduction: The anatomy of gonadal veins is of growing importance, with an increased number of laparoscopic and open intra-abdominal surgical procedures. Gonadal veins display great variability concerning their course, number, and termination site. Aim: To explore the possible anatomical variations in the course and termination pattern of testicular veins. Materials and Methods: A cross-sectional study was conducted on 35 human male cadavers in Gandhi Medical College, Secunderabad, Telangana, India and All India Institute of Medical Sciences (AIIMS), Bibinagar, Telangana, India, from 2019-2021. The course numbers and drainage pattern of testicular veins were analysed for any anatomical variations. Results: Two out of the 35 (5.71%) cases had shown multiple testicular veins. One case showed quadruple testicular veins with two oblique communicating veins on the right side and double left testicular veins on the left side. In another case, double right testicular veins with a single vein on the left side. However, no significant variations of arteries were noted in any of these cases. Conclusion: Detailed knowledge of variable presentations of testicular veins is necessary for vascular surgeons, urologists, nephrologists, and radiologists in safeguarding these veins intraoperatively and also, reducing any postoperative vascular complications.
Factors Affecting Wound Healing after Laparotomy at a Tertiary Care Hospital, Odisha, India: A Prospective Interventional Study
Authors: Panigrahi Sucheta , Sethy Sudarsan , Bhoi kishan , Saurav Supreet , Panigrahi Manish
Published: April 2023

Introduction: Wound healing after the injury occurs after various phases and is affected by multiple factors. It plays a psychological role for the surgeon and patients, influencing morbidity and hospital stay. Factors like age, nutrition, use of steroids, type of incision, diabetes and infection plays an essential role in wound healing. Aim: To assess the factors influencing patients and affecting wound healing after laparotomy. Materials and Methods: This prospective interventional study was carried in the Department of General Surgery, Veer Surendra Sai Institute of Medical Sciences and Research, Burla, Sambalpur, Odisha, India, between October 2019 and September 2021 on 100 patients undergoing laparotomy, admitted in the surgical ward. Data was collected regarding clinical history including co-morbid conditions (diabetes, hypertension, anaemia), general physical and systemic examination and relevant diagnostic investigations. The collected data was tabulated as mean±Standard Deviation (SD), frequency (n) and percentage (%) for proper analysis, represented in form of pie-charts and bar diagrams. Results: A total of 100 patients undergoing laparotomies were studied, with maximum participants in 61-70 years of age. Out of these, 40 patients were found to have delayed wound healing (mean age: 62.2 years), 10 (25%) were females and 30 (75%) were males. Wound infection was most common (n=38) factor for delayed healing followed by diabetes (16 patients out of 30 known diabetics), and consumption of alcohol (14 patients out of 24 known alcoholics) and smoking (20 out of 25 known chronic smokers). Conclusion: The incidence of delayed healing was higher in the present study with an increased incidence of wound infection. Clinical factors of low haemoglobin, low serum albumin, history of diabetes mellitus, alcohol and smoking, were observed to be associated with delayed wound healing along with physiological predisposing factors of increasing age and gender. These factors should be considered, and efforts can be made to manage these risk factors for proper care of patients.
Extranodal Rosai-Dorfman Disease of the Nasal Septum: A Case Report
Authors: Kesari Santosh Prasad , Ojha Kartikeya , . Piyush , Rao HR Sohan
Published: April 2023

Rosai-Dorfman Disease (RDD) is a rare, benign histiocytic proliferative disorder mostly involving the lymph nodes. Extranodal disease can occur in the skin and soft tissue including the mucosal surface, central nervous system, gastrointestinal tract, and breast. Here, a case of a 17-year-old Indo-asian girl is presented, who came to the Ear Nose Throat (ENT) Outpatient Department (OPD) with a mass in her left nostril for the past two years. A sessile globular mass from the left nasal septum was seen during diagnostic visual endoscopy. A Computerised Tomography (CT) scan of the paranasal sinus revealed a rather large right maxillary sinus with a soft tissue density lesion filling it and obliterating the osteomeatal complex, while blood tests revealed an increased eosinophilic count. The nasal tumour was removed, and its histological analysis revealed characteristics of RDD. This is typically sporadic histiocytosis with emperipolesis in the cells. Clinically, the condition is benign, and all that is required is conservative therapy and periodic monitoring of its progression. Surgical excision is rarely advised until the disease has grown to an unmanageable size and is causing respiratory impairment or a cosmetic deformity. Currently, therapy revolves around surgical and immunosuppressive treatments, but the optimal diagnostic and therapeutic management of RDD remains to be defined.
An Exploration of How to Carry out Introductory Course Civics on Artificial Intelligence in the Construction of National First-class Major
Authors: Xiang Jian
Published: April 2023

This paper explores the integration of ideological and political education in the Introduction to Artificial Intelligence course within the context of first-class major construction. It discusses innovative teaching methods, such as case studies, teamwork, and classroom discussions, aimed at fostering students' ideological and political qualities. By analyzing teaching practices and research, the study demonstrates the unique and feasible nature of civic education innovation in applied undergraduate institutions. The findings offer valuable insights for the reform and innovation of AI introductory courses in thinking and politics education, ultimately enhancing students' comprehensive quality and meeting the demands of educational reform.
Screening and Partial Characterization of Secondary Metabolite of Salacia korthalsiana Miq. (Polipog) Root Decocted Extract
Authors: Madario Mary Jane , Tonog Merle N. , Lim Karina Milagros C.
Published: April 2023

A cough is a sudden and often repetitive reflex that helps clear the air passages from secretions, irritants, and foreign particles, including microbes. Coughing can be due to a respiratory tract infection or choking, smoking, air pollution, asthma, chronic bronchitis, medications, and a   variety of many other factors which becomes an emerging health problem in the globe. This study investigated the role of Salacia korthalsiana Miq. (Polipog) root decoction as anti-coughing agent through screening and partial characterization of secondary metabolite. The physical properties determined in the root sample were: boiling point 99.3 , brownish red in color with a pleasant odor; pH 5.86 and soluble in water and ethanol which makes the Polipog root extract polar. Phytochemical screening was used for the determination of active chemical properties for anti-cough. Further, Fourier Transform Infrared spectroscopy were used to determine the active functional group for anti-cough. Among the chemical properties determined for anti-cough only steroids and saponins are present, which is an antitussive and expectorant agent. Fourier Transform Infrared analysis showed that the main functional groups present are:  the amine and ethers, which are medically active for medicinal purposes. Therefore, Polipog roots are positively active for anti-cough.
Research of the Composition of Phosphogypsum Produced During the Extracting of Phosphoric Acid from Ordinary Phosphorite Powder by the Clinker Method
Authors: Sultonov B. E. , Nodirov A. A. , Xolmatov D. S.
Published: April 2023

In this article, processes of washing phosphogypsum with water, that formed during obtaining extractive phosphoric acid, by clinker method, from ordinary phosphorite powder (OPP) that is a raw material of Central Kyzylkum were studied. The phosphogypsum formed by washing a sample of phosphogypsum formed in 103% concentration of sulfuric acid without mixing with water, that obtained in the ratio OPP:H2O=1,0:2,5 was found to contain 2,55% P2O5, 29,90% CaO and 42,45% SO3. The acceptable sizes of washing the same phosphogypsum sample have been determined, mixing in different amounts of hot water. Phosphogypsum obtained in acceptable sizes contains 0,75% P2O5, 30,51% CaO and 43,58% SO3. When washing phosphogypsum samples with water, it saves 2.5 times  the amount of water and causes to reduce the amount of P2O5 in its composition by at least 3 times. The amount of CaSO4 in the received phosphogypsum sample is increased from 79 to 86%. The samples of phosphogypsum formed without mixing with water and mixing with water were analyzed by X-ray phase analysis and their mutual salt contents were compared.
Gliricidia Leaf Meal in Broiler Chickens Diet: Effects on Performance, Carcass, and Haemato-biochemical Parameters
Authors: D. Oloruntola O.
Published: April 2023

Aims: This study seeks to access the influence of Gliricidia leaf meal on broiler chickens’ growth performance, carcass traits, and haemato-biochemical parameters.

Study Design:  Completely randomised design.

Place and Duration of Study: The 56-day feeding trial was carried out at the Teaching and Research Farm of Agricultural Technology Department, The Federal Polytechnic, Ado Ekiti, Nigeria.

Methodology:  Fresh Gliricidia sepium leaves were harvested, shade dried and milled to produce leaf meal. Three diets were formulated to contain Gliricidia sepium leaf meal (GLM) at 0 (control), 5 and 10% level. A total number of 144 day-old chicks of arbor acres were assigned to 3 dietary treatments of 3 replicates of 16 chicks per replicate in a completely randomised design experiment.

Results: The total weight gain and total feed intake was lower (P<0.05) in broiler chicken fed 10% GLM inclusive diet (1890.48 g/b and 5188.90 g/b) compare to the total weight gain and total feed intake of those fed the control (2188.04 g/b and 5754.14 g/b) and 5% GLM inclusive diet (2154.31 g/b and 5579.04 g/b). The slaughter weight, dressed weight and dressed percentage of birds fed 10% GLM inclusive diet were lower (P<0.05) than those fed the control and 5% GLM inclusive diets. The liver, kidney and gizzard relative weights were higher (P<0.05) in the birds fed 10% GLM inclusive diet compared to those fed rest diets. The white blood cell count of birds fed control diet and 5% GLM inclusive diet were similar (P>0.05) but significantly (P<0.05) lower than white blood cell counts of birds fed 10% GLM inclusive diet. The cholesterol levels of birds fed GLM inclusive diets (5 and 10%) were lower (P<0.05) compare to those birds fed the control diet.

Conclusion: The dietary gliricidia leaf meal at 5% inclusion level supports normal body weight gain, feed intake, carcass traits and normal health status of the broiler chickens.
Design and Implementation of Optimized Controller for E-Vehicles
Authors: Parthasarathy S. , Prabu P. G. Harish , Thiagarajan R. Praveen , Kumar R. Arun
Published: April 2023

The dwindling supply of fossil fuels has created a shortage, while the discharge of CO2 emissions from internal combustion engines poses a serious threat to the environment through air pollution. Hence, electric vehicles (EVs) play a vital role in the automotive sector by decreasing CO2 emissions and reducing the usage of fossil fuels. The performance of EVs is also comparable to that of internal combustion engines used in automobiles. The faithful operation of an EV relies on three main parts: the battery, controller, and motor. This proposed research article emphasizes the design, implementation, and testing of a low-cost EV controller that operates at a lower frequency than other conventional high-frequency controllers. A PMDC motor is used as a load to rotate the wheels, and a Lithium-Ion battery powers the electric vehicle. The controller, which is the major part of the vehicle, is used to control the PMDC motor. The controller controls the output voltage, and the converter is controlled by the controller. Compared to conventional vehicles or transport, electric vehicles are more efficient, and this E-vehicle's load capability will be increased. The ripple of the output voltage from the converter will be reduced by adding capacitors.
Advances in Ovarian Cancer Care and Unmet Treatment Needs for Patients With Platinum Resistance
Authors: Richardson Debra L. , Eskander Ramez N. , O’Malley David M.
Published: April 2023

Importance

Platinum-based chemotherapy has been the standard of care for ovarian cancer for the past 3 decades. Although most patients respond to platinum-based treatment, emergence of platinum resistance in recurrent ovarian cancer is inevitable during the disease course. Outcomes for patients with platinum-resistant ovarian cancer are poor, and options remain limited, highlighting a substantial unmet need for new treatment options.

Observations

This review summarizes the current and evolving treatment landscape for platinum-resistant ovarian cancer with a focus on the development of novel compounds. Biologic and targeted therapies such as bevacizumab and poly (ADP-ribose) polymerase (PARP) inhibitors—originally approved in the platinum-resistant setting but since withdrawn—are now used in the up-front or platinum-sensitive setting, prolonging the duration of platinum sensitivity and delaying the use of nonplatinum options. The greater use of maintenance therapy and the emphasis on using platinum beyond first-line treatment has most likely been associated with a greater number of lines of platinum therapy before a patient is designated as having platinum-resistant ovarian cancer. In this contemporary setting, recent trials in platinum-resistant ovarian cancer have mostly had negative outcomes, with none having a clinically significant effect on progression-free or overall survival since the approval of bevacizumab in combination with chemotherapy. Nonetheless, a multitude of new therapies are under evaluation; preliminary results are encouraging. A focus on biomarker-directed treatment and patient selection may provide greater success in identifying novel therapies for treating platinum-resistant ovarian cancer.

Conclusions and Relevance

Although many clinical trials in platinum-resistant ovarian cancer have had negative outcomes, these failures provide insights into how clinical trial design, biomarker-directed therapy, and patient selection could facilitate future successes in platinum-resistant ovarian cancer treatment.
Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation
Authors: Mo Shaobo , Ye Li , Wang Dongyang , Han Lingyu , Zhou Shuang , Wang Hui , Dai Weixing , Wang Yichao , Luo Wenqin , Wang Renjie , Xu Ye , Cai Sanjun , Liu Rui , Wang Zheng , Cai Guoxiang
Published: April 2023

Importance

Detection of molecular residual disease and risk stratification as early as possible may improve the treatment of patients with cancer. Efficient pragmatic tests are therefore required.

Objective

To measure circulating tumor DNA (ctDNA) with 6 DNA methylation markers in blood samples and to evaluate the association of the presence of ctDNA with colorectal cancer (CRC) recurrence throughout the disease course.

Design, Setting, and Participants

In this multicenter prospective longitudinal cohort study performed from December 12, 2019, to February 28, 2022, 350 patients with stage I to III CRC were recruited from 2 hospitals for collection of blood samples before and after surgery, during and after adjuvant chemotherapy, and every 3 months for up to 2 years. A multiplex, ctDNA methylation, quantitative polymerase chain reaction assay was used to detect ctDNA in plasma samples.

Results

A total of 299 patients with stage I to III CRC were evaluated. Of 296 patients with preoperative samples, 232 (78.4%) tested positive for any of the 6 ctDNA methylation markers. A total of 186 patients (62.2%) were male, and the mean (SD) age was 60.1 (10.3) years. At postoperative month 1, ctDNA-positive patients were 17.5 times more likely to relapse than were ctDNA-negative patients (hazard ratio [HR], 17.5; 95% CI, 8.9-34.4; P < .001). The integration of ctDNA and carcinoembryonic antigen tests showed risk stratification for recurrence with an HR of 19.0 (95% CI, 8.9-40.7; P < .001). Furthermore, ctDNA status at postoperative month 1 was strongly associated with prognosis in patients treated with adjuvant chemotherapy of different durations and intensities. After adjuvant chemotherapy, ctDNA-positive patients had a significantly shorter recurrence-free survival than did the ctDNA-negative patients (HR, 13.8; 95% CI, 5.9-32.1; P < .001). Longitudinal ctDNA analysis after the postdefinitive treatment showed a discriminating effect in that ctDNA-positive patients had poorer recurrence-free survival than did the ctDNA-negative patients (HR, 20.6; 95% CI, 9.5-44.9; P < .001). The discriminating effect was enhanced (HR, 68.8; 95% CI, 18.4-257.7; P < .001) when ctDNA status was maintained longitudinally. Postdefinitive treatment analysis detected CRC recurrence earlier than radiologically confirmed recurrence, with a median lead time of 3.3 months (IQR, 0.5-6.5 months).

Conclusions and Relevance

The findings of this cohort study suggest that longitudinal assessment of ctDNA methylation may enable the early detection of recurrence, potentially optimizing risk stratification and postoperative treatment of patients with CRC.
Visualization of Short Posterior Ciliary Artery Insertion Due to Posterior Staphyloma and Myopic Chorioretinal Atrophy
Authors: Moreira Giovanna Vieira , Marback Eduardo Ferrari , Leitão Guerra Ricardo Luz
Published: April 2023

This case report describes the visualization of a short posterior ciliary artery insertion as a result of posterior staphyloma and chorioretinal atrophy in a patient in their 50s with pathologic myopia.
Genomic and immune characteristics of HER2‐mutated non‐small‐cell lung cancer and response to immune checkpoint inhibitor‐based therapy
Authors: Tu Hai‐Yan , Yin Kai , Zhao Xiaotian , Ke E‐E , Wu Si‐Pei , Li Yang‐Si , Zheng Mei‐Mei , Liu Si‐Yang Maggie , Xu Chong‐Rui , Sun Yue‐Li , Lin Jia‐Xin , Bai Xiao‐Yan , Zhang Yi‐Chen , Zhou Qing , Yang Jin‐Ji , Zhong Wen‐Zhao , Wang Bing‐Chao , Zhang Xu‐Chao , Zhu Dongqin , Yang Lingling , Ou Qiuxiang , Wu Yi‐Long
Published: April 2023

The efficacy of immunotherapy in advanced HER2‐mutated non‐small‐cell lung cancer (NSCLC) remains incomprehensively studied. A total of 107 NSCLC patients with de novo HER2 mutations were retrospectively studied at Guangdong Lung Cancer Institute [GLCI cohort, exon 20 insertions (ex20ins): 71.0%] to compare clinical/molecular features and immune checkpoint inhibitor (ICI)‐based therapy efficacy between patients with ex20ins and non‐ex20ins. Two external cohorts (TCGA, n = 21; META‐ICI, n = 30) were used for validation. In the GLCI cohort, 68.2% of patients displayed programmed death‐ligand 1 (PD‐L1) expression < 1%. Compared with ex20ins patients, non‐ex20ins patients had more concurrent mutations in the GLCI cohort (P < 0.01) and a higher tumour mutation burden in the TCGA cohort (P = 0.03). Under ICI‐based therapy, advanced NSCLC patients with non‐ex20ins had potentially superior progression‐free survival [median: 13.0 vs. 3.6 months, adjusted hazard ratio (HR): 0.31, 95% confidence interval (CI): 0.11–0.83] and overall survival (median: 27.5 vs. 8.1 months, adjusted HR: 0.39, 95% CI: 0.13–1.18) to ex20ins patients, consistent with findings in the META‐ICI cohort. ICI‐based therapy may serve as an option for advanced HER2‐mutated NSCLC, with potentially better efficacy in non‐ex20ins patients. Further investigations are warranted in clinical practice.
MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness
Authors: Gonzalez‐Molina Jordi , Hahn Paula , Falcão Raul Maia , Gultekin Okan , Kokaraki Georgia , Zanfagnin Valentina , Braz Petta Tirzah , Lehti Kaisa , Carlson Joseph W.
Published: April 2023

Fibrillar collagen deposition, stiffness and downstream signalling support the development of leiomyomas (LMs), common benign mesenchymal tumours of the uterus, and are associated with aggressiveness in multiple carcinomas. Compared with epithelial carcinomas, however, the impact of fibrillar collagens on malignant mesenchymal tumours, including uterine leiomyosarcoma (uLMS), remains elusive. In this study, we analyse the network morphology and density of fibrillar collagens combined with the gene expression within uLMS, LM and normal myometrium (MM). We find that, in contrast to LM, uLMS tumours present low collagen density and increased expression of collagen‐remodelling genes, features associated with tumour aggressiveness. Using collagen‐based 3D matrices, we show that matrix metalloproteinase‐14 (MMP14), a central protein with collagen‐remodelling functions that is particularly overexpressed in uLMS, supports uLMS cell proliferation. In addition, we find that, unlike MM and LM cells, uLMS proliferation and migration are less sensitive to changes in collagen substrate stiffness. We demonstrate that uLMS cell growth in low‐stiffness substrates is sustained by an enhanced basal yes‐associated protein 1 (YAP) activity. Altogether, our results indicate that uLMS cells acquire increased collagen remodelling capabilities and are adapted to grow and migrate in low collagen and soft microenvironments. These results further suggest that matrix remodelling and YAP are potential therapeutic targets for this deadly disease.
Nitric oxide hinders club cell proliferation through Gdpd2 during allergic airway inflammation
Authors: Yue Qing , Li Kuan , Song Zhaoyu , Wang Qi , Wang Jianhai , Li Xue , Li Yu , Zhang Qiuyang , Zhu Yu , Chen Huaiyong
Published: April 2023

Excessive nitric oxide (NO) is often observed in the airways of patients with severe asthma. Here, we show that the NO donor diethylamine NONOate impairs the proliferative capacity of mouse club cells and induces club cell apoptosis, cell cycle arrest, and alterations in lipid metabolism. Our data suggest that NO inhibits club cell proliferation via upregulation of Gdpd2 (glycerophosphodiester phosphodiesterase domain containing 2). During ovalbumin (OVA) challenge, apoptotic club cells are observed, but surviving club cells continue to proliferate. OVA exposure induces Gdpd2 expression; Gdpd2 knockout promotes the proliferation of club cells but inhibits goblet cell differentiation. Elimination of airway NO was found to inhibit goblet cell differentiation from club cells during OVA challenge. Our data reveal that excessive NO might be related to airway epithelial damage in severe asthma and suggest that blockade of the NO‐Gdpd2 pathway may be beneficial for airway epithelial restoration.
Autonomous perception method of multi‐degree‐of‐freedom industrial robot arm trajectory
Authors: Qian Xiaochuan
Published: April 2023

In this study, a novel autonomous sensing method of multi‐degree‐of‐freedom industrial robot arm trajectory is proposed. The research takes the distance sensor to collect environmental data, and takes the point cloud data scanned by 3D laser as the basis. The environment model of multi‐degree‐of‐freedom industrial robotic arm is established by Iterative Closest Point (ICP). Then the target object is calibrated by binocular imaging technology. Subsequently, angle of each joint of multi‐degree‐of‐freedom industrial robotic arm is calculated to determine the spatial attitude of the robotic arm. In addition, 3D LiDAR is installed at the end of the robotic arm, and the end trajectory of multi‐degree‐of‐freedom industrial robotic arm is sensed autonomously by using the optimal function. The proposed method has advantages of high accuracy and short sensing time in autonomous sensing of multi‐degree‐of‐freedom industrial robot arm trajectory.