bluuebunny/crossref_metadata_2025 huggingface dataset:
Tumor-associated CD75s- and iso-CD75s-gangliosides are potential targets for adjuvant therapy in pancreatic cancer
Authors: Distler Ute , Souady Jamal , Hülsewig Marcel , Drmić-Hofman Irena , Haier Jörg , Denz Axel , Grützmann Robert , Pilarsky Christian , Senninger Norbert , Dreisewerd Klaus , Berkenkamp Stefan , Schmidt M. Alexander , Peter-Katalinić Jasna , Müthing Johannes
Published: August 2008

Pancreatic adenocarcinoma confers one of the highest mortality rates in malignant human tumors with very poor prognosis. Because as yet no treatments are available that produce a substantial survival benefit for this fatal neoplasia, new therapeutic concepts are urgently required to support cancer standard treatment. In search of tumor-associated gangliosides with therapeutic background, we probed a random collection of cancerous and adjacent normal postoperative tissue samples from 38 patients for the expression of CD75s- and iso-CD75s-gangliosides. We exhaustively analyzed the expression of CD75s-1-ganglioside (IV6Neu5Ac-nLc4Cer) and structurally closely related iso-CD75s-1-ganglioside (IV3Neu5Ac-nLc4Cer) by means of immunohistology of cryosections and semiquantitative TLC of tissue lipid extracts combined with mass spectrometry. CD75s-1- and iso-CD75s-1-ganglioside showed an elevated expression in 42% and 66% of the tumors, respectively, indicating a significant association with neoplastic transformation (P = 0.001). Thus, increased expression of CD75s-1- and iso-CD75s-1-gangliosides renders these cell surface molecules promising candidates for oncologic applications. Further statistical analysis revealed a significant enhancement of CD75s-1-ganglioside in the group of less differentiated tumors (grade >2) suggesting this ganglioside as a potential marker for poor differentiation. The CD75s-specific antitumor drug rViscumin, which represents the recombinant counterpart of the ribosome-inactivating lectin viscumin, has successfully passed clinical phase I trials and provides an opportunity for treating pancreatic cancer. Consequently, if an enhanced expression is existent in malignant tissues, we propose the targeting of CD75s-gangliosides with rViscumin as a novel potential strategy in adjuvant treatment of pancreatic malignancies. [Mol Cancer Ther 2008;7(8):2464–12]
SIRT1 Contributes in Part to Cisplatin Resistance in Cancer Cells by Altering Mitochondrial Metabolism
Authors: Liang Xing-Jie , Finkel Toren , Shen Ding-Wu , Yin Jun-Jie , Aszalos Adorjan , Gottesman Michael M.
Published: August 2008

Tumors frequently develop resistance to cisplatin, a platinum drug used as a cornerstone of present-day chemotherapy regimens, significantly decreasing its usefulness in the clinic. Although it is known that cisplatin-resistant (CP-r) cancer cells commonly grow more slowly and exhibit reduced uptake of various compounds, including nutrients, the effect of tumor metabolism on cisplatin resistance is unclear. It was found that in CP-r cells, uptake of 2-deoxyglucose was reduced due to dysfunction and altered morphology of mitochondria compared with cisplatin-sensitive parental cancer cells. The CP-r cells overexpressed SIRT1, a histone deacetylase that plays a central role in DNA damage response and transcriptional silencing. Incubation of drug-sensitive cells in low glucose medium induced the expression of SIRT1 and increased cellular resistance to cisplatin. Reduced SIRT1 expression by a SIRT1 SMART small interfering RNA duplex sensitized the >20-fold resistant CP-r cells to cisplatin treatment 1.5- to 2-fold, and SIRT1 overexpression by SIRT1 cDNA transfection increased cisplatin resistance in cisplatin-sensitive cells by 2- to 3-fold. Our findings therefore suggest that reduced glucose use and altered mitochondrial metabolism mediated by SIRT1 is one of several alterations that contribute to cellular resistance to cisplatin. (Mol Cancer Res 2008;6(9):1499–506)
Suppression of the p53-Dependent Replicative Senescence Response by Lysophosphatidic Acid Signaling
Authors: Kortlever Roderik M. , Brummelkamp Thijn R. , van Meeteren Laurens A. , Moolenaar Wouter H. , Bernards René
Published: August 2008

Lysophosphatidic acid (LPA) is a lipid mediator of a large number of biological processes, including wound healing, brain development, vascular remodeling, and tumor progression. Its role in tumor progression is probably linked to its ability to induce cell proliferation, migration, and survival. In particular, the ascites of ovarian cancers is rich in LPA and has been implicated in growth and invasion of ovarian tumor cells. LPA binds to specific G protein–coupled receptors and thereby activates multiple signal transduction pathways, including those initiated by the small GTPases Ras, Rho, and Rac. We report here a genetic screen with retroviral cDNA expression libraries to identify genes that allow bypass of the p53-dependent replicative senescence response in mouse neuronal cells, conditionally immortalized by a temperature-sensitive mutant of SV40 large T antigen. Using this approach, we identified the LPA receptor type 2 (LPA2) and the Rho-specific guanine nucleotide exchange factor Dbs as potent inducers of senescence bypass. Enhanced expression of LPA2 or Dbs also results in senescence bypass in primary mouse embryo fibroblasts in the presence of wild-type p53, in a Rho GTPase–dependent manner. Our results reveal a novel and unexpected link between LPA signaling and the p53 tumor-suppressive pathway. (Mol Cancer Res 2008;6(9):1452–60)
Antitumor Activity of Bortezomib Alone and in Combination with Trail in Human Acute Myeloid Leukemia
Authors: Conticello Concetta , Adamo Luana , Vicari Luisa , Giuffrida Raffaella , Iannolo Gioacchin , Anastasi Gabriele , Caruso Laura , Moschetti Gaetano , Cupri Alessandra , Palumbo Giuseppe Antonio , Gulisano Massimo , De Maria Ruggero , Giustolisi Rosario , Di Raimondo Francesco
Published: August 2008

Acute myeloid leukemia (AML) is a malignant disease characterized by abnormal proliferation of clonal precursor cells. Although different strategies have been adopted to obtain complete remission, the disease actually progresses in about 60–70% of patients. Bortezomib has been used in multiple myeloma and other lymphoid malignancies because of its antitumor activity. Here we examined the sensitivity of bone marrow cells from AML patients (34 patients: 25 newly diagnosed, 4 relapsed, 5 refractory) to bortezomib alone or in combination with TRAIL, a member of the TNF family that induces apoptosis in tumor cells while sparing normal cells. Bortezomib induced cell death in blasts from each patient sample. The cytotoxic effect was dose- and time-dependent (concentration from 0.001 to 10 µM for 24 and 48 h) and was associated with a downregulation of Bcl-xL and Mcl-1, an upregulation of TRAIL-R1, TRAIL-R2, p21, activation of executioner caspases and a loss of the mitochondrial membrane potential. Moreover, low doses of bortezomib primed TRAIL-resistant AML cells for enhanced TRAIL-mediated killing. These results suggest that a combination of proteasome inhibitors and TRAIL could be effective for treating AML patients, even patients who are refractory to conventional chemotherapy.
The Prevalence of Multiple Sclerosis in the Middle East
Authors: Al-Hashel Jasem , Besterman Aaron D. , Wolfson Christina
Published: August 2008

Background: The prevalence of multiple sclerosis (MS) in the Middle East has been reported to be low to medium. Methods: To verify this assertion we conducted a review of published data on the occurrence of MS in the Middle East.Results: Fourteen studies reporting on the prevalence of MS in the Middle East were initially identified, 5 of which were excluded due to inadequate data or serious methodological limitations. The data from the 9 included studies suggested that the prevalence of MS may vary widely within the Middle East, from low to high. However, these 9 studies were inconsistent in case ascertainment, inclusion criteria and methods of prevalence calculation, and most did not include age/sex standardization. Conclusion: Methodological inconsistencies among studies make it difficult to be confident in drawing conclusions about the prevalence of MS in the Middle East. Nevertheless, there is little evidence to support the assertion that the prevalence of MS in the Middle East is low to medium. Rather, the prevalence of MS in the Middle East may range from low to high, depending on the specific population and environment of study. However, to confirm these findings, further epidemiological research is needed.
Environmental Epidemiology of Essential Tremor
Authors: Louis Elan D.
Published: August 2008

Background: Essential tremor (ET) is one of the most common neurological disorders. Despite this, the disease mechanisms and etiology are not well understood. While susceptibility genotypes undoubtedly underlie many ET cases, no ET genes have been identified thus far. As with many other progressive, degenerative neurological disorders, it is likely that environmental factors contribute to the etiology of ET. Environmental epidemiology is the study in specific populations or communities of the effect on human health of physical, biologic and chemical factors in the external environment. The purpose of this article is to review current knowledge with regards to the environmental epidemiology of ET. Results: As will be discussed, a series of preliminary case-control studies in recent years has begun to explore several candidate toxins/exposures, including harmane (1-methyl-9H-pyrido[3,4-b]indole), lead and agricultural exposures/pesticides. Conclusions: While several initial results are promising, as will be discussed, additional studies are needed to more definitively establish whether these exposures are associated with ET and if they are of etiological importance.
Coadministration of Endothelial and Smooth Muscle Progenitor Cells Enhances the Efficiency of Proangiogenic Cell-Based Therapy
Authors: Foubert Philippe , Matrone Gianfranco , Souttou Boussad , Leré-Déan Carole , Barateau Véronique , Plouët Jean , Le Ricousse-Roussanne Sophie , Lévy Bernard I. , Silvestre Jean-Sébastien , Tobelem Gérard
Published: August 2008

Cell-based therapy is a promising approach designed to enhance neovascularization and function of ischemic tissues. Interaction between endothelial and smooth muscle cells regulates vessels development and remodeling and is required for the formation of a mature and functional vascular network. Therefore, we assessed whether coadministration of endothelial progenitor cells (EPCs) and smooth muscle progenitor cells (SMPCs) can increase the efficiency of cell therapy. Unilateral hindlimb ischemia was surgically induced in athymic nude mice treated with or without intravenous injection of EPCs (0.5×10
6
), SMPCs (0.5×10
6
) and EPCs+SMPCs (0.25×10
6
+0.25×10
6
). Vessel density and foot perfusion were increased in mice treated with EPCs+SMPCs compared to animals receiving EPCs alone or SMPCs alone (
P
<0.001). In addition, capillary and arteriolar densities were enhanced in EPC+SMPC–treated mice compared to SMPC and EPC groups (
P
<0.01). We next examined the role of Ang-1/Tie2 signaling in the beneficial effect of EPC and SMPC coadministration. Small interfering RNA directed against Ang-1–producing SMPCs or Tie2-expressing EPCs blocked vascular network formation in Matrigel coculture assays, reduced the rate of incorporated EPCs within vascular structure, and abrogated the efficiency of cell therapy. Production of Ang-1 by SMPCs activates Tie2-expressing EPCs, resulting in increase of EPC survival and formation of a stable vascular network. Subsequently, the efficiency of EPC- and SMPC-based cotherapy is markedly increased. Therefore, coadministration of different types of vascular progenitor cells may constitute a novel therapeutic strategy for improving the treatment of ischemic diseases.
The Role of Carotid Artery Stenting and Carotid Endarterectomy in Cognitive Performance
Authors: De Rango Paola , Caso Valeria , Leys Didier , Paciaroni Maurizio , Lenti Massimo , Cao Piergiorgio
Published: August 2008

Background and Purpose—

Change in cognition is being increasingly recognized as an important outcome measure; however, the role of carotid revascularization on this issue remains to be determined. It is still under debate whether carotid artery stenting and carotid endarterectomy have the same influence on neuropsychological functions.

Summary of Review—

This article systematically reviews recent literature in an attempt to clarify this issue. A total of 32 papers reporting on neurocognition after carotid endarterectomy (n=25), carotid artery stenting (n=4), or carotid artery stenting versus carotid endarterectomy (n=3) were identified. The studies were different for many methodological factors, eg, sample size, type of patients and control group, statistical measure, type of test, timing of assessment, and so on. There was a lack of consensus in defining the improvement or impairment after either carotid artery stenting or carotid endarterectomy. Furthermore, there were nonuneqivocal results regarding the same domain of assessment (memory, visuomotor, attention). Based on available evidence, it is probable that carotid endarterectomy as well as carotid artery stenting do not change neuropsychological function “per se.”

Conclusions—

Assessment of cognition after carotid revascularization is probably influenced by many confounding factors such as learning effect, type of test, type of patients, and control group, which are often minimized in their importance. The role of carotid revascularization is to prevent stroke in patients with severe carotid stenosis as highlighted by previous large randomized trials. Although an effect of carotid revascularization on cognition could be missed as a consequence of underpowered studies included in this review, at this time, no prediction can be done regarding its repercussions on higher intellectual functions. Larger studies appropriately designed and powered to assess cognition after carotid revascularization might change this view.
Use of Carotid Intima-Media Thickness to Identify Patients With Ischemic Stroke and Transient Ischemic Attack With Low Yield of Cardiovascular Sources of Embolus on Transesophageal Echocardiography
Authors: Ward R. Parker , Lammertin Georgeanne , Virnich Daniel E. , Polonsky Tamar S. , Lang Roberto M.
Published: August 2008

Background and Purpose—

Carotid intima-media thickness (CIMT) is associated with systemic atherosclerosis and cardioembolic conditions and predicts the risk of recurrent strokes. We sought to establish the relationship between CIMT and cardiovascular sources of embolus (CSE) on transesophageal echocardiography (TEE) and hypothesized that a noninvasive strategy of CIMT assessment and transthoracic echocardiography bubble study would identify patients with ischemic stroke or transient ischemic attack in whom TEE would provide little incremental diagnostic yield.

Methods—

In 180 patients with ischemic stroke or transient ischemic attack of undetermined origin referred for TEE, we prospectively performed CIMT measurement/plaque screen (Phase 1, n=96) or CIMT measurement/plaque screen and transthoracic echocardiography bubble study (Phase 2, n=84) before TEE. Phase 1 results were used to construct receiver operating characteristic curves to demonstrate the ability of CIMT to detect CSE on TEE and to identify the optimal CIMT cutoff value for prospective strategy testing (Phase 2).

Results—

In Phase 1, CIMT was found to correlate with TEE markers of aortic atherosclerosis, including complex aortic plaques, and combined CSE. The optimal CIMT cutoff for detection of CSE on TEE was 0.78 mm. In Phase 2, a positive noninvasive strategy test (CIMT ≥0.78 mm, +carotid plaque, and/or a positive transthoracic echocardiography bubble study) was present in 61%. The prevalence of CSE on TEE was significantly higher among those with a positive compared with a negative noninvasive strategy test (65% versus 9%,
P
<0.001), and this strategy had a sensitivity of 92% and a negative predictive value of 91% for the detection of any CSE on TEE.

Conclusion—

In patients with stroke or transient ischemic attack of undetermined origin, a noninvasive strategy of CIMT assessment/plaque screen and transthoracic echocardiography bubble study can identify patients in whom further invasive evaluation with TEE will be of low diagnostic yield.
Furries from A to Z (Anthropomorphism to Zoomorphism)
Authors: Bernstein Penny , Paolone Nicholas , Higner Justin , Gerbasi Kathleen , Conway Samuel , Privitera Adam , Scaletta Laura
Published: August 2008

This study explored the furry identity. Furries are humans interested in anthropomorphic art and cartoons. Some furries have zoomorphic tendencies. Furries often identify with, and/or assume, characteristics of a special/totem species of nonhuman animal. This research surveyed both furries (n = 217) and non-furry individuals (n = 29) attending a furry convention and a comparison group of college students (n = 68). Furries commonly indicated dragons and various canine and feline species as their alternate-species identity; none reported a nonhuman-primate identity. Dichotomous responses (“yes” or “no”) to two key furry-identity questions (“do you consider yourself to be less than 100% human” and “if you could become 0% human, would you”) produced a two-by-two furry typology. These two independent dimensions are self-perception (undistorted versus distorted) and species identity (attained versus unattained). One-quarter of the furry sample answered “yes” to both questions, placing them in the “Distorted Unattained” quadrant. This type of furry has certain characteristics paralleling gender-identity disorder. To explore this parallel, the furry typology, and the proposed construct of “Species Identity Disorder” needs further research.
Functional Links Between Intimate Partner Violence and Animal Abuse: Personality Features and Representations of Aggression
Authors: Gupta Maya
Published: August 2008

Acts of intimate partner violence (IPV) and abuse of nonhuman animals are common, harmful, and co-occurring phenomena. The aim of the present study was to identify perpetrator subtypes based on variable paths hypothesized to influence physical violence toward both partners and nonhuman animals: (a) callousness and instrumental representations of aggression and (b) rejection-sensitivity and expressive representations of aggression. Strong associations emerged between callousness and instrumental representations and between rejection-sensitivity and expressive representations. For males, callousness directly predicted both IPV and animal abuse. For females, rejection-sensitivity predicted IPV. Instrumental representations mediated the relationship between callousness and animal abuse for females but not for males. Results suggest that IPV and animal abuse functionally interconnect, that perpetration of animal abuse may differ in function across gender, and that identifying distinct pathways to violence may facilitate violence prediction and prevention.
Empathic Correlates of Witnessing the Inhumane Killing of an Animal: An Investigation of Single and Multiple Exposures
Authors: Morton Larry , Daly Beth
Published: August 2008

Seventy-five adults who reported witnessing at least 1 animal being killed inhumanely participated in a study of 5 measures of empathy from the Interpersonal Reactivity Index (IRI) (Davis, 1980) and the Animal Attitude Scale (AAS) (Herzog, Betchart, & Pittman, 1991): Perspective Taking (PT), Fantasy (FS), Emotional Concern (EC), Personal Distress (PD), and Animal Attitudes (AA). Females showed greater sensitivity (4 of 5 scales) on a 2-way MANOVA with Sex (male, female) and Witnessing Killing (never, once, multiple) as independent variables. Individuals who witnessed multiple killings were higher on PT and lower on PD scales. Lower PD for those who witnessed multiple killings suggests hardening or habituation related to exposure. Alternatively, they may lack resistance to involvement in situations leading to animal violence. Higher PT scores related to multiple killings may indicate a natural leaning toward the cognitive—rather than affective—or dissociation between cognitive and affective. A shift to the cognitive, as a defense mechanism, suggests a dissociation hypothesis. Implications extend to the need for refined research in the developmental sequence of animal abuse and empathy, and humane education.
Reasons for Companion Animal Guardianship (Pet Ownership) from Two Populations
Authors: Staats Sara , Wallace Heidi , Anderson Tara
Published: August 2008

The purpose of this study is to extend and replicate previously published results from a random probability sample of university faculty. The sample assessed reasons given for companion-animal guardianship (owning pets) and for belief in the beneficial health effects of owning pets. In this replication and extension design, these two non-random samples responded to the same questionnaire items as those addressed to university faculty. Results indicated that avoidance of loneliness was the most frequent reason for owning pets among both students and middle-aged community members. This result is consistent with the view that animals provide social support and companionship to humans at various stages of the life cycle. Suggesting an emergent feature of the human-nonhuman animal bond, both groups selected, “the pet helps keep me active” as the second-most common reason. Older women reported a greater belief in the health-giving benefits of pet ownership than did younger persons or men. This belief may contribute to human benefits of pet ownership and requires further research.
Second Generation Argentinean Migrants in Catalonia: Ethnic Mobility and Mobilization
Authors: Alarcón Amado , Garzón Luis
Published: August 2008

Drawing on some preliminary findings of an ongoing research project on second-generation Argentinean migrants and their language use and social mobility in Catalonia, this paper focuses on the link between social mobility and ethnic mobilization. Using findings from interviews with migrants that came to Spain in the 1970s and 1980s as well as their children who have grown up in Spain, we demonstrate the degree of integration and labor market participation by both generations. Our research also emphasizes the roles political action and language learning play in their integration.
Globalization and Inequality
Authors: Weede Erich
Published: August 2008

Globalization may be defined by a worldwide division of labor and increasing trade between nations. This is inconceivable without expanding economic freedom across the world. Free trade and globalization increase competition, productivity, and economic growth rates. In spite of increasing inequality within many large economies – including the US, China, and Russia – inequality between human beings and households has been reduced. Since catch-up growth in big Asian economies contributes to Schumpeterian “creative destruction,” it necessitates rich economies to adapt, to become ever more entrepreneurial and innovative. This generates resentment and strengthens protectionist excesses which might serve some special interests. But protectionism harms the global economy, the prospects of the poor to grow out of poverty and, worse still, likely increases the risk of war.
Up-dating Its Strategies and Amplifying Its Frames: The Landless Rural Workers' Movement in Brazil and the Displacement of the Struggle for Land
Authors: Caldeira Rute
Published: August 2008

The present article examines the possible loss of prominence of land occupations as a strategy of struggle within the Movimento dos Trabalhadores Rurais sem Terra's (Landless Rural Workers' Movement or MST) repertoires of contention. I argue that this possible decline began during Cardoso's government and that the movement is in the process of institutionalizing other strategies of struggle, which have yet to prove as effective as land occupations. Some legal amendments during Cardoso's administration undermined the effectiveness and even the usefulness of land occupations. The MST has nevertheless updated its frames and its strategies of struggle, and reinforced its role as a national and global social movement. Findings in the present article are supported by several interviews collected during field research, academic and newspaper articles, and general sources about the matter.
HIV/AIDS and Economic Development: Evidence from Thirty-Nine Sub-Saharan Countries
Authors: Kahende Jennifer , Hoch Irving
Published: August 2008

This paper (1) examines whether there is a bilateral relationship between HIV/AIDS and economic development; (2) estimates the impact of HIV/AIDS on economic development; and (3) identifies some of the factors affecting the spread of HIV/AIDS. Analyses are based on data from 39 sub-Saharan African countries for the period 1989-1998. HIV/AIDS negatively impacted economic development, with no evidence of a reciprocal relation. Expenditures on health and education as well as political freedom had positive impacts on development, but negative impacts on HIV/AIDS incidence. Expenditures on female education impacted development and HIV/AIDS incidence.
Changing Demographic of Labor Force and Productivity: A Case of Japan
Authors: Koshal Manjulika , Gupta Ashok , Koshal Rajindar , Akkihal Chandra , Mine Yoichi
Published: August 2008

For the period of 1978-2003, this paper examines the relationship between changing productivity and demographic characteristics of Japan's labor force. The results of this study reveal four important and interesting characteristics of the Japanese labor force. First, there is a negative relationship between productivity growth and turnover rates. Second, the participation rate of younger workers in the labor force has declined; this has resulted in a decline in the percentage of younger workers (15-34 years old). Third, the gender distribution of the labor force has not changed in any significant way. Fourth, the unemployment rate has increased by more than four times. These labor force changes have contributed to fluctuations in productivity growth.
Food Production, Food Imports, and the WTO's Special and Differential Provisions to Trade: The Case of Pacific Island Countries
Authors: Gani Azmat
Published: August 2008

This paper examines the extent of food production, imports, and trade policy opportunities in terms of the special and differential treatment (SDT) in Pacific Island countries (PICs). It is revealed that stagnating per capita incomes and high incidence of poverty are lowering the quality of life among a significant proportion of the PIC population. PICs' well-being is likely to be further worsened by falling and stagnating food production and significant rises in food prices as a result of food imports that range between 14 to 29 percent of total imports. PICs' future development is likely to be hampered by the looming economic fallout arising from regional integration. Thus, ensuring food self-sufficiency is essential for improved well-being. In this regard, the PICs window of opportunity is to maximize the utility of the SDT under the World Trade Organisations (WTO) provisions. Urgent governmental attention is required in terms of calibrating regional country-specific composite measures of trade and development parameters so as to allow the capacity of the PICs to bargain for the SDT with greater clarity, strength and meaning.
Whither the Roots? Achieving Conceptual Depth in Psychology of Religion
Authors: Hill Peter C. , Gibson Nicholas J. S.
Published: August 2008

Should psychology of religion undergo a disciplinary renaissance and, if so, what might it look like? In this paper we explore that question by discussing the benefits of a better grounding of the field within mid-level theories from general psychology that provide it with greater conceptual depth. Such discussion will focus on three already existing and variously productive lines of research as case studies: attribution processes, attachment styles, and religious coping. These case studies represent lines of research at three developmental stages: 1) infancy, with little visible return but with signs of promise (attribution), 2) adolescence, with dividends already yielded but also with promise not yet fully realized (attachment), and 3) maturity, where a fruitful harvest has already been experienced but yet without decline (coping). Regardless of developmental position, it is argued that research in psychology of religion will be enhanced to the extent that it achieves conceptual depth by being framed in terms of mid-level theories.
Counter-Intuitive Religious Representations from the Perspective of Early Intersubjective Development and Complex Representational Constellations. A Methodological Reflection
Authors: Nynäs Peter
Published: August 2008

My main concern in this article is the relevance of theoretically integrative approaches. I argue that such approaches are methodologically better equipped for the psychology of religion because they correspond with the inherent complexity of religiosity. In order to concretize this matter I critically evaluate the hypothesis proposed by some cognitive researchers that the attraction of counter-intuitive representations provides an explanation of religion. Irrelevant aspects are left out in this hypothesis. In contrast to this I rely on cognitive-analytic perspectives that are based on a broader theoretical foundation. This generates a more complete picture that also connects to the tradition built on Otto's (1923) idea of the wholly other. From this perspective it is more plausible to assume that religious representations are trajectories of the early evolving tripartite sense of self, other and world and, further, formed by individual mentalization capacity. This can be conceptualized in terms of interplay between specific complex representational constellations rooted in different phases of early development. Integrative approaches that depict mental activity as a dynamic and multifaceted phenomenon embedded in intersubjectivity are relevant for the psychology of religion.
The Impact of Postmodernization on Existential Health in Sweden: Psychology of Religion's Function in Existential Public Health Analysis
Authors: DeMarinis Valerie
Published: August 2008

The article presents a portrait and analysis of the existential-psychocultural situation in postmodern Sweden. Drawing from recent research exploring psychology of religion and existential worldviews, and the Swedish findings from the international World Values Survey, an argument is made for thinking about existential function and dysfunction as public health issues. This is portrayed against the background of Sweden as one of the most secularized countries and simultaneously a country with one of the most encompassing welfare systems. Psychology of religion's updated role here would be to take responsibility for identifying and assessing the categories of function and dysfunction for an existential public health system. This role would also include the planning of policy for societal existential wellbeing, as well as planning prevention and intervention efforts for avoiding existential epidemiology. This new role fits well with public health's third revolution agenda focusing on health, wellbeing and quality of life.
Mapping Fundamentalisms: The Psychology of Religion as a Sub-Discipline in the Understanding of Religiously Motivated Violence
Authors: Savage Sara , Liht Jose
Published: August 2008

The psychology of religion has a vital role to play in understanding religiously motivated violence, and thus contributing to its prevention. Psychological pathology alone fails to explain either terrorists’ actions or the fundamentalist religiosity that is co-opted as its legitimation. Normal social psychological processes such as uncertainty reduction, terror management, social identity, meaning making (through religion), in combination with cognitive factors such as intratextuality and low integrative complexity, provide a more adequate understanding of the radicalization of young people, some of whom go on to commit violence against hated out-groups.
Extending the Psychology of Religion: A Call for Exploration of Psychological Universals, More Inclusive Approaches, and Comprehensive Models
Authors: Reich K. Helmut
Published: August 2008

Extensions of ongoing research identified in the introduction to this special issue (Reich & Hill, this issue) are discussed here with farther reaching objectives: researching more intensely psychological universals thought to underlie religion, taking a more inclusive approach to psychology of religion, and constructing more comprehensive models. All three involve conscious experience, to which some observations are devoted. Remarks about the relationships between these research areas conclude the article.
Religiosity Scales: What Are We Measuring in Whom?
Authors: Cutting Marsha , Walsh Michelle
Published: August 2008

At least 177 scales are available to researchers who want to measure religiosity, but questions exist as to exactly what these scales are measuring and in whom they are measuring it. A review of these scales found a lack items designed to measure ethical action in society or the world as a prophetic response to the experience of the divine. Instead, the vast majority of scales focus on internal experiences and beliefs or institutional relationships. A review of scale norm groups found that norm groups often are not fully described, particularly in the area of race/ethnicity, and when they are described, they reveal an over-reliance on convenience samples of college students and an under-representation of racial/ethnic minority groups. Examples of scales with more fully described and more representative norm groups are given, and recommendations are offered for researchers using and developing religiosity scales.
The Phenomenology and Potential Religious Import of States of Consciousness Facilitated by Psilocybin
Authors: Richards William A.
Published: August 2008

Accompanying the resumption of human research with the entheogen (psychedelic drug), psilocybin, the range of states of consciousness reported during its action, including both nonmystical and mystical forms of experience, is surveyed and defined. The science and art of facilitating mystical experiences is discussed on the basis of research experience. The potential religious import of these states of consciousness is noted in terms of recognizing the reality of the spiritual, in better understanding the biochemistry of revelation, and in exploring the potentially positive contributions that mystical consciousness may effect in psychological treatment.
Linking Leadership to Student Learning: The Contributions of Leader Efficacy
Authors: Leithwood Kenneth , Jantzi Doris
Published: August 2008

Purposes: This study aimed to improve our understanding of the nature, causes and consequence of school leader efficacy, including indirect influences on student learning. We asked about district contributions to school leader efficacy, whether leader self- and collective efficacy responded to the same or different district conditions and the effects of leader efficacy on conditions in the school and the learning of students.

Methods: Evidence for the study was provided by 96 principal and 2,764 teacher respondents to two separate surveys, along with student achievement data in language and math averaged over 3 years. Path analytic techniques were used to address the objectives for the study.

Findings: In this study, school leaders' collective efficacy was an important link between district conditions and both the conditions found in schools and their effects on student achievement. School leaders'sense of collective efficacy also had a strong, positive, relationship with leadership practices found to be effective in earlier studies.

Implications: These results suggest that district leaders are most likely to build the confidence and sense of collective efficacy among principals by emphasizing the priority they attach to achievement and instruction, providing targeted and phased focus for school improvement efforts and by building cooperative working relationships with schools.
Disseminating Evidence-Based Practices for Adults With PTSD and Severe Mental Illness in Public-Sector Mental Health Agencies
Authors: Frueh B. Christopher , Grubaugh Anouk L. , Cusack Karen J. , Elhai Jon D.
Published: August 2008

Posttraumatic stress disorder (PTSD) remains largely untreated among adults with severe mental illnesses (SMI). The treatment of psychotic symptoms usually takes precedence in the care of adults with SMI. Such oversight is problematic in that PTSD in SMI populations is common (19%-43%), contributes a significant illness burden, and hinders mental health care. Yet few public-sector mental health agencies routinely provide specialized services for PTSD. The purpose of the article is to describe strategies and efforts to disseminate trauma-focused empirically based practices in a public-sector mental health system. Identified challenges include limited resources and commitment; knowledge deficits, attitudes, and biases; and limited practice accountability at provider, facility, and system levels. Proposed strategies for overcoming these challenges are to set clear goals, nurture broad-based organizational commitment and key stakeholder involvement, implement specialty training efforts to provide information and change attitudes, provide ongoing supervision, conduct fidelity monitoring, and ensure accountability to the extent possible.
Implementation of Evidence-Based Services for Youth
Authors: Stumpf Roxanna E. , Higa-McMillan Charmaine K. , Chorpita Bruce F.
Published: August 2008

Although provider knowledge is a potential barrier in the dissemination of evidence-based services for youth, research in this area is currently limited by a lack of instrumentation. The present study examined the utility of the Knowledge of Evidence-Based Services Questionnaire (KEBSQ), a 40-item self-report measure designed to assess reporter knowledge of evidence-based practices (EBPs) in the treatment of youth psychopathology. The KEBSQ items encompass practice elements identified in both empirically supported and unsupported protocols used in the treatment of four prevalent childhood problem areas: anxious/avoidant, depressed/withdrawn, disruptive behavior, and attention/hyperactivity. Findings from the present investigation lend support for the basic psychometric properties of the KEBSQ. Results supported temporal stability, discriminative validity, and sensitivity to training. Practical implications to the dissemination of EBPs, areas for future research, and limitations are discussed.
Gambling as a Search for Justice: Examining the Role of Personal Relative Deprivation in Gambling Urges and Gambling Behavior
Authors: Callan Mitchell J. , Ellard John H. , Will Shead N. , Hodgins David C.
Published: August 2008

The present article explores the hypothesis that gambling might serve a justice-seeking function for some people, as gambling might offer a means to pursuing desirable outcomes that people feel they deserve but might be unable or unwilling to attain through conventional means. In Study 1, across two separate samples, self-reports of personal relative deprivation predict problem gambling and gambling urges over and above relevant control variables. In Study 2, the authors manipulate personal relative deprivation by informing participants that they have either less or more discretionary income than “similar others.” They then give participants $20 and the opportunity to gamble. The results show that a greater percentage of participants who are “relatively deprived” (vs. “not relatively deprived”) opt to gamble. Two manipulation validation studies demonstrate that the “relatively deprived” participants are preoccupied with justice during a modified Stroop task and feel resentful. Implications for understanding why people gamble are discussed.
The Linkage Between Deviant Lifestyles and Victimization
Authors: Chen Xiaojin
Published: August 2008

A small but growing body of research has demonstrated the merits of linking victimization to a life course perspective. Although cross-sectional studies have shown a strong association between deviant lifestyles and victimization, few have assessed this association from the life course perspective. Drawing data from a prospective, longitudinal study, the current study examines this association in a group of high school adolescents. Results from latent growth curve models show that (a) victimization and deviant lifestyles, measured as involvement in delinquent activities, affiliation with deviant peers, and time spent on unsupervised activities change over time; and (b) change in deviant lifestyle patterns leads to change in victimization patterns over time.
Training in Cognitive Behavioral Therapy in Psychiatry Residency
Authors: Sudak Donna M.
Published: August 2008

In January 2001, Accreditation Council of Graduate Medical Education accredited general psychiatry training programs were charged with the requirement to train residents in cognitive-behavioral therapy (CBT) to a level of competence. Programs were given the responsibility to delineate standards for trainees, to determine measures of competence, and to provide remediation for deficiencies in performance. Effective education in CBT in general and child and adolescent psychiatry residency training can be more successful when educators understand the barriers to implementation of empirically supported therapies (ESTs). Robust training programs in CBT must take into account cultural barriers to psychotherapy training and the educational demands placed on residents in adult and child and adolescent psychiatry. Resources for training and evaluation materials are available to training directors and teachers.
Population Health Clinical Experiences at an Agency Serving Individuals With Developmental Disabilities
Authors: Ailey Sarah H. , O'Rourke Marilyn E.
Published: August 2008

The American Association of Colleges of Nursing's (AACN) Essentials of baccalaureate and master's degree education require teaching population health skills in nursing programs. Clinical site placement for learning population health skills is hoped to be beneficial for both students and the agencies. This article reports on the experience of placing undergraduate and graduate student groups at an agency serving adults and children with intellectual and developmental disabilities (I/DD) as well as many chronic health conditions. Each group of students developed a population health assessment and program plan, with each group building on the efforts of previous groups. The work of multiple student groups has assisted the agency in improving care for their clients, managing health issues associated with aging and chronic health conditions, and making organizational system changes. Lessons can be drawn from these experiences that are of benefit to others developing population health clinical experiences for nursing students.
Internet-Based Health Information Seeking Among Low-Income, Minority Seniors Living in Urban Residential Centers
Authors: Campbell Robert James
Published: August 2008

This article discusses the results of an exploratory study designed to measure low-income, minority elderly adults Internet-based health information—seeking activities. The study is a part of a program designed to teach residents, living in high-rise urban communities, how to use the Internet to locate health information. By teaching minority seniors how to locate Internet-based health information, it is hoped that they will seek more information regarding their health conditions, treatments, and medications. The results of the study draw five inferences regarding participant's health information—seeking behavior: The retrieved information helps the elderly understand their health problems; retrieved information will not lead the elderly to engage in self-care, nor will it engage them enough to change health care providers; retrieved information can change elderly eating and exercise patterns, and retrieved information can affect the treatments the elderly receive for their illnesses.
Targeted deletion of α-adducin results in absent β- and γ-adducin, compensated hemolytic anemia, and lethal hydrocephalus in mice
Authors: Robledo Raymond F. , Ciciotte Steven L. , Gwynn Babette , Sahr Kenneth E. , Gilligan Diana M. , Mohandas Narla , Peters Luanne L.
Published: August 2008

In the red blood cell (RBC), adducin is present primarily as tetramers of α- and β-subunits at spectrin-actin junctions, or junctional complexes. Mouse RBCs also contain small amounts of γ-adducin. Platelets contain α- and γ-adducin only. Adducin functions as a barbed-end actin capping protein to regulate actin filament length and recruits spectrin to the ends of actin filaments. To further define adducin's role in vivo, we generated α-adducin knockout mice. α-Adducin is absent in all tissues examined in homozygous null mice. In RBCs, β- and γ-adducin are also absent, indicating that α-adducin is the limiting subunit in tetramer formation at the spectrin-actin junction. Similarly, γ-adducin is absent in α-null platelets. α-Adducin–null mice display compensated hemolytic anemia with features characteristic of RBCs in hereditary spherocytosis (HS), including spherocytes with significant loss of surface area, decreased mean corpuscular volume (MCV), cell dehydration, and increased osmotic fragility. Platelets maintain their normal discoid shape, and bleeding times are normal. α-Adducin–null mice show growth retardation at birth and throughout adulthood. Approximately 50% develop lethal communicating hydrocephalus with striking dilation of the lateral, third, and fourth ventricles. These data indicate that adducin plays a role in RBC membrane stability and in cerebrospinal fluid homeostasis.