bluuebunny/crossref_metadata_2025 huggingface dataset:
Do Polygenic Indices Capture “Direct” Effects on Child Externalizing Behavior Problems? Within-Family Analyses in Two Longitudinal Birth Cohorts
Authors: Tanksley Peter T. , Brislin Sarah J. , Wertz Jasmin , de Vlaming Ronald , Courchesne-Krak Natasia S. , Mallard Travis T. , Raffington Laurel L. , Karlsson Linnér Richard , Koellinger Philipp , Palmer Abraham A. , Sanchez-Roige Sandra , Waldman Irwin D. , Dick Danielle , Moffitt Terrie E. , Caspi Avshalom , Harden K. Paige
Published: August 2024

Failures of self-control can manifest as externalizing behaviors (e.g., aggression, rule-breaking) that have far-reaching negative consequences. Researchers have long been interested in measuring children’s genetic risk for externalizing behaviors to inform efforts at early identification and intervention. Drawing on data from the Environmental Risk Longitudinal Twin Study ( N = 862 twins) and the Millennium Cohort Study ( N = 2,824 parent–child trios), two longitudinal cohorts from the United Kingdom, we leveraged molecular genetic data and within-family designs to test for genetic associations with externalizing behavior that are not affected by common sources of environmental influence. We found that a polygenic index (PGI) calculated from genetic variants discovered in previous studies of self-controlled behavior in adults captures direct genetic effects on externalizing problems in children and adolescents when evaluated with rigorous within-family designs (βs = 0.13–0.19 across development). The PGI for externalizing behavior can usefully augment psychological studies of the development of self-control.
Her Lips Are Sealed: Effects of Negative Feedback on Women’s Participation in Online Political Discussions
Authors: Chen Zhaodi , Han Junghun
Published: August 2024

Research shows that women engage less in online political discussions than men, but it remains unclear under what conditions this gender difference intensifies. Using a unique survey experiment with a demographically representative sample of 1,032 individuals, the authors examine how negative feedback mechanisms, a critical aspect of the online environment, affect men’s and women’s intention to participate in these discussions. The authors focus on two feedback mechanisms: dislike and deletion. The findings suggest that dislike does not discourage women from participating in online political discussions. However, women show significantly lower participation intentions when their posts risk deletion. In contrast, men’s participation intentions are not deterred by either feedback mechanism. These findings suggest that context-specific feedback mechanisms are important in understanding the gender gap in online political participation, emphasizing women’s sensitivity to online environments where their contributions might be erased.
Alterations in plasma proteome during acute COVID-19 and recovery
Authors: Suski Maciej , Olszanecka Agnieszka , Stachowicz Aneta , Kiepura Anna , Terlecki Michał , Madej Józef , Rajzer Marek , Olszanecki Rafał
Published: August 2024

Background

The severe course of COVID-19 causes cardiovascular injuries, although the mechanisms involved are still not fully recognized, linked, and understood. Their characterization is of great importance with the establishment of the conception of post-acute sequelae of COVID-19, referred to as long COVID, where blood clotting and endothelial abnormalities are believed to be the key pathomechanisms driving circulatory system impairment.

Methods

The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalization due to SARS-CoV-2 infection and six months after recovery by targeted SureQuant acquisition using PQ500 panel.

Results

In total, we identified 167 proteins that were differentially regulated between follow-up and hospitalization, which functionally aggregated into immune system activation, complement and coagulation cascades, interleukins signalling, platelet activation, and extracellular matrix organization. Furthermore, we found that temporal quantitative changes in acute phase proteins correlate with selected clinical characteristics of COVID-19 patients.

Conclusions

In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.
Conceptualisations of good care and conflicts in live-in migrant care arrangements for people with dementia – perspectives of family caregivers in Germany
Authors: Grenz Adele , von Kutzleben Milena
Published: August 2024

Background

In Germany, live-in migrant carers provide essential social, emotional and physical support to a growing number of community-dwelling people with dementia. However, opaque legal regulations and employment models as well as a lack of formal supervision for families employing live-in migrant carers contribute to the vulnerability of these already strained arrangements. This study analyses the family caregivers’ perspective, their conceptualisations of good dementia live-in migrant care and conflicts that arise in live-in care arrangements.

Methods

The study adopted a qualitative-explorative approach. We conducted focus groups with family caregivers (n = 15) to learn about their perspectives on and experiences with live-in care as a model of home-based dementia care. Due to the restrictions of the COVID-19 pandemic, data collection took place online, which enabled us to include participants from all over Germany in our sample. Data were analysed with qualitative content analysis.

Results

In this paper, two main categories, Indicators of good live-in migrant care for people with dementia and perceived conflicts, are presented. We identified indicators applied by family caregivers to assess the quality of care provided by migrant live-in carers and its outcomes for the person with dementia. These relate primarily to interpersonal and emotional aspects and a person-centred attitude towards the person with dementia. Conflicts arise when the needs and personalities within the triad do not match, due to intransparent and unreliable work of and communication with the placement agencies, or permanent crisis as a result of the German model with alternating live-in carers.

Conclusion

Our findings point to the complex dynamics and relationships within live-in care triads and support the theoretical assumption that taking into account the needs of all actors involved is essential for good and stable care arrangements. The conceptualisations of family caregivers of good dementia live-in migrant care offer starting points for a scientific as well as a social and health policy debate about the future regulation of this model of care.
Comparison of misfit and roughness of CAD-CAM ZrO, selective laser sintered CoCr and preformed Ti implant abutment crowns
Authors: Vohra Fahim , Alsaif Rawan , Khan Rawaiz , Bukhari Ishfaq A
Published: August 2024

Background

Marginal misfit and surface roughness of customized implant abutments is critical for restorative success. However, little is known about the comparison of misfit and surface roughness of CAD-CAM Zirconium oxide (ZrO), selective laser melting (SLM) Cobalt Chrome (CoCr) and preformed abutments. The aim of the study is to investigate the relation of misfit and micro-roughness of selective laser melting (SLM), preformed and CAD-CAM implant abutments.

Methods

Thirty internal connection, endosseous dental implants (Ø 4.0 mm x 10 mm, Dentium) were mounted in Polymethyl methacrylate vertically. Ten preformed Titanium alloy (Ti) abutments with 1 mm soft tissue height and Ø 4.5 mm were included as controls. Ten each of Y-TZP and SLM-CoCr, abutment/crowns were fabricated using CAD-CAM milling (CAD-CAM-ZrO) and SLM techniques. Surface micro-roughness (Ra) of the fabricated implant abutment/crown was evaluated with a 3D optical non-contact microscope. All implant restorations were torqued to implants (30 Ncm) using a Tohnichi BTGE digital torque gauge and were analyzed with Bruker micro-CT (Skyscan 1173) to detect micro-gaps at pre-selected points at implant abutment interface. The Ra and misfit data were compared using ANOVA, Tukey-Kramer, Kruskal-Wallis test and Pearson correlation (p < 0.05).

Results

Mean Ra among SLM CoCr abutments [0.88 (0.09) µm] were lower than CAD-CAM-ZrO and higher than preformed Ti abutments. Horizontal misfit among SLM-CoCr [45.43 (9.41) µm] and preformed Ti [36.87 (13.23) µm] abutments was not statistically different (p > 0.05). Misfit was significantly higher in Y-TZP samples compared to SLM-CoCr (p = 0.031) and preformed Ti abutments (p = 0.01). Preformed Ti abutments showed significantly lower misfit compared to SLM-CoCr abutments (p = 0.01). A positive linear correlation was observed between the surface roughness (Ra) and vertical misfit (r = 0.61, p < 0.05).

Conclusion

SLM CoCr abutments showed rough surface compared to preformed Ti abutments, while horizontal misfit was comparable among SLM-CoCr and preformed abutments. Misfit was significantly greater in Y-TZP abutments, compared to SLM and preformed abutments. SLM abutment fabrication technique needs further improvement to provide better fit and surface topography.
Mating of unfed, engorged, and partially to fully gravid Aedes aegypti (Diptera: Culicidae) female mosquitoes in producing viable eggs
Authors: Mayilsamy Muniaraj , Subramani Surendiran , Veeramanoharan Rajamannar , Vijayakumar Asifa , Asaithambi Amuthalingam T. , Murugesan Arthi , Selvaraj Nandhakumar , Balakrishnan Vijayakumar , Rajaiah Paramasivan
Published: August 2024

Background

Understanding the relationship between blood-feeding and mating is important in effectively managing the most well-adapted vector insect, Aedes aegypti (Linnaeus). Although extensive studies have investigated the behavioural aspects of Aedes such as blood-feeding, mating, and their relationship, several knowledge gaps still exist. Therefore, the present study was undertaken to determine the possibility of successful mating by unfed, engorged, and partially to fully gravid (up to 5 days after blood-feeding with fully developed eggs) female Ae. aegypti mosquitoes and production of viable eggs.

Methods

Mating of sexually mature adult Aedes aegypti was allowed in three different ways. In control 1, the females were allowed to mate before taking blood meal, and in control 2, the females were not at all allowed to mate. In the experiment, the females were separated into six categories, viz. D-0 to D-5. In D-0, the females were allowed to mate immediately after the bloodmeal and, in D-1, the females were allowed to mate on the first day of blood feeding, likewise, the females of D-2, D-3, D-4 and D-5 were allowed to mate on 2nd, 3rd, 4th and 5th day of blood feeding. Ovitrap was uniformly kept on the 4th day of blood feeding for the cages D-0 to D-3 for 1 h and then removed and for the cages D-4, and D-5, the ovitrap was kept on 4th and 5th day of blood feeding for 1h immediately after mating. The total number of eggs and the total number of hatching were counted. In the subsequent days, the entire experiment was replicated two times with different cohorts of mosquitoes, and the mean value of three experiments was used to draw Excel bars with 5% error bars and also for the statistical analysis.

Results

It was found that mating just before oviposition was sufficient to produce 1581 eggs (70% compared with control) and fertilize 1369 eggs (85% compared with total eggs laid), which is far higher than the 676 non-hatching (unfertilized) eggs (30%) laid by unmated females. Although mating is not essential for producing eggs, our study shows that even brief exposure to the semen and seminal fluids greatly enhances the oviposition and hatching efficiency, even if the mating occurs just before oviposition. However, those females mating before blood-feeding and those mating after blood-feeding produced 2266 and 2128 eggs, with hatching rates of 96.78% and 95.54%, respectively. Hence, the retention time of seminal fluid in the female seems to influence the number of eggs laid and the number of eggs hatched.

Conclusions

In general, mating is possible in Ae. aegypti even minutes before oviposition and is sufficient to produce a greater number of viable eggs.

Graphical Abstract
Measure of 90Y-glass microspheres residue post-TARE using PET/CT and potential impact on tumor absorbed dose in comparison 99mTc-MAA SPECT/CT dosimetry
Authors: Boughdad Sarah , Duran Rafael , Prior John O. , da Mota Michael , De Carvalho Mélanie Mendes , Costes Julien , Firsova Maria , Gnesin Silvano , Schaefer Niklaus
Published: August 2024

Background

Transarterial radio-embolization (TARE) became a routine procedure for non-resectable liver tumor mainly hepatocellular carcinoma (HCC). Personalized dosimetry to the index lesion increased tumor response rate. However, there is no requirement to measure the precise activity injected during TARE. We measured 90Y-glass microspheres residue (90Y-Res) in the application system after TARE and assessed its potential impact on the tumor absorbed dose (AD) previously planned with 99mTc MAA SPECT/CT.

Methods

We measured 90Y-Res using PET/CT in all patients that underwent TARE using 90Y-glass-microspheres for non-resectable liver tumors over one year.

Results

90Y-Res was measured in 34 patients (HCC n = 22) with 61 injections, 93.1 ± 94.6 MBq [2–437] that was 4.8 ± 3.5% [0.2–13.7] in comparison to the activity measured in the sealed TheraSphere™ vial (ρ = 0.697; p < 0.001).

Conclusion

We reported an average of 5% 90Y-Res using PET/CT after TARE with the strongest association to the activity in the TheraSphere™ vial. Therefore, when a high 90Y-Res is suspected on the survey meter, a 90Y-PET/CT scan of 90Y-Res might be useful as a first step to estimate if the target lesion received the recommended AD, especially in HCC patients with borderline tumor dosimetry on the pre-treatment 99mTc-MAA SPECT/CT.
ProcSAGE: an efficient host threat detection method based on graph representation learning
Authors: Xu Boyuan , Gong Yiru , Geng Xiaoyu , Li Yun , Dong Cong , Liu Song , Liu Yuling , Jiang Bo , Lu Zhigang
Published: August 2024

Advanced Persistent Threats (APTs) achieves internal networks penetration through multiple methods, making it difficult to detect attack clues solely through boundary defense measures. To address this challenge, some research has proposed threat detection methods based on provenance graphs, which leverage entity relationships such as processes, files, and sockets found in host audit logs. However, these methods are generally inefficient, especially when faced with massive audit logs and the computational resource-intensive nature of graph algorithms. Effectively and economically extracting APT attack clues from massive system audit logs remains a significant challenge. To tackle this problem, this paper introduces the ProcSAGE method, which detects threats based on abnormal behavior patterns, offering high accuracy, low cost, and independence from expert knowledge. ProcSAGE focuses on processes or threads in host audit logs during the graph construction phase to effectively control the scale of provenance graphs and reduce performance overhead. Additionally, in the feature extraction phase, ProcSAGE considers information about the processes or threads themselves and their neighboring nodes to accurately characterize them and enhance model accuracy. In order to verify the effectiveness of the ProcSAGE method, this study conducted a comprehensive evaluation on the StreamSpot dataset. The experimental results show that the ProcSAGE method can significantly reduce the time and memory consumption in the threat detection process while improving the accuracy, and the optimization effect becomes more significant as the data size expands.
Differences and potential mechanisms of theta oscillation and temporoparietal and temporal-central networks in temporal lobe epilepsy patients with unilateral hippocampal sclerosis
Authors: Qiu Chenxi , Zhong Chenxi , Liu Ying , Wang Liju , Tang Yingying , Liu Zhiyi , Guo Sijia , Jiang Yingqi , Li Enzhi , Lu Jing , Yan Bo , Hao Xiaoting , Zhou Dong
Published: August 2024

Background

There is a lack of further exploration of the epileptogenic network of specific types of epilepsy, such as unilateral hippocampal sclerosis (HS), and there is an urgent need to find exact evidence to confirm the consistency of its brain network changes.

Methods

We enrolled 22 mesial temporal lobe epilepsy with hippocampal sclerosis (mTLE-HS) patients to compare the differences in brain activity between 22 healthy controls (HCs) and them. Resting-state electroencephalography (EEG) was also measured. Then, we calculated the power spectral density and phase locking values in and between these electrodes.

Results

The results showed the increased theta power was related to the high severity of epilepsy in the temporal, parietal, and central regions in mTLE-HS patients, and there were positive correlations between theta power in the contralateral temporal region and seizure frequency. Theta power in the ipsilateral parietal lobe is positively correlated with the number of anti-seizure medications (ASMs), but not with the usage of third-generation ASMs. Meanwhile, the temporal lobe of mTLE-HS patients had more connectivity with parietal lobe and central region.

Conclusions

Theta power is an important EEG indicator of mTLE-HS, positively correlates with epilepsy severity and seizure frequency, and has network properties that can be observed outside the lesion. Moreover, the usage of third-generation ASMs did not affect the risk of increased theta power. Lastly, the temporoparietal and temporal-central networks are likely to be causative pathways in epilepsy patients with cognitive impairment. This study provides a potential guideline for the treatment of mTLE-HS in clinical practice.
Evaluating the effectiveness of a Portage program on reducing parenting stress and enhancing child development in autism spectrum disorders
Authors: Borg Radwa M. , Ahmed Marwa Mostafa , Raafat Omnia , Makawi Shirin , Soliman Saeed S. Abduljalil
Published: August 2024

Background

Autism spectrum disorder (ASD) manifests in early childhood and significantly impairs social and communicative functions. Parents of children with ASD typically experience higher levels of stress compared to parents of children with other disabilities or health issues. This study investigates how a home-based early intervention known as the Portage program influences parenting stress and improves family awareness by using the Parental Stress Scale (PSS), and Family Awareness Scale. We enrolled 41 children diagnosed with ASD and their parents in this study. The median age of the children was 4 years, with a predominance of males (80%). We measured changes in parenting stress and family awareness as primary outcomes, with the children’s behavior as a secondary outcome.

Results

Post-intervention assessments showed statistically significant improvements in parenting stress and family awareness (P < 0.001). Additionally, notable improvements were observed in the children’s social, language, self-help, cognitive, and motor skills, as well as general developmental age and ratio.

Conclusions

A 3-month engagement with the Portage program markedly reduced stress among parents and increased family awareness regarding ASD. Significant advancements were also noted in multiple developmental domains of the children involved.
Factor analysis of hepcidin on cardiac iron overload and fibrosis among thalassemia major children
Authors: Rohimi Syarif , Siswanto Bambang Budi , Mansyur Muchtaruddin , Gatot Djajadiman , Sutanto Ina , Pandelaki Jacub , Soesanto Amiliana M. , Ontoseno Teddy
Published: August 2024

Background

Cardiac iron overload is a common cause of death in thalassemia major and is associated with hepcidin, which is primary iron homeostasis. Therapeutics that could increase hepcidin levels or act as hepcidin agonists might help treat the abnormal iron absorption in individuals with β-thalassemia and related disorders. We aimed to verify the structure and study the relationship of release variables, hepcidin, cardiac iron overload, or fibrosis.

Methods

A cross-sectional study was conducted among thalassemia majors, aged 6–18 years at Rumah Sakit Anak dan Bunda Harapan Kita Indonesia, between January 2019 and May 2020. Clinical data, hepcidin-25, interacting variables laboratory test, MRIT2* used to assess cardiac iron overload, late gadolinium enhancement (LGE), and soluble suppression of tumoregenicity2 (ST2) to assess fibrosis were studied. The correlation test was performed with SPSS version 20, Amos 22 was used to assess confirmatory factor analysis (CFA), and squared multiple correlation (SMC) was used to determine the proportion of total variation explained by the model.

Results

We recruited 80 patients, of those 8 (10%) were cardiac iron overload, 5 (5.25%) were fibrosis, and 3 (3,75%) were ST2 > 35 mg/dL. CFA showed variables that interact with hepcidin release were Hb, reticulocyte-He (Re-He), HIF-1α, Immature granulocyte (IG), hs-CRP, IL-6, ferritin, and transferrin saturation. There was no direct hepcidin role in cardiac iron overload and fibrosis. No interacting variable role on hepcidin. SMC of hepcidin on cardiac iron overload was 20%.

Conclusion

Factor analysis of hepcidin was Hb, Ret-He, HIF-1α, IG, hs-CRP, IL-6, ferritin, and transferrin saturation. No direct hepcidin role in cardiac iron overload and fibrosis. Hepcidin explains approximately 20% of the total variation in cardiac iron overload.
A summit on a Global Patient co-Owned Cloud (GPOC)
Authors: Lidströmer Niklas , Davids Joe , ElSharkawy Mohamed , Ashrafian Hutan , Herlenius Eric
Published: August 2024

Background

During the last thirty years the world has benefited from the increasing adoption to cloud-based storage of personal health records. The concept of a Global Patient co-Owned Cloud (GPOC) of personal health records is presented in the GPOC Series, which contains a systematic review and meta-analysis, a global survey among 100% of the UN member states and a technical sandbox environment. GPOC contains patient co-ownership of personal health records. The global survey showed a consensus for the realisation of a GPOC.

Methods

Here, we present a Delphi styled GPOC Summit. It also contains a final vote, that validates the results of the previous GPOC Survey. Hence, the Summit contains both multiple rounds of discussion and a voting.

Results

At the GPOC Summit a unanimous consensus for patient co-ownership of the personal health records was expressed. The majority of participants underlined that GPOC may benefit global health, transfers of the personal health records globally and the dissemination of evidence-based medicine across the globe. The plausible advantages for patients, both refugees and travellers and for developing economies were underlined. GPOC, as a large substrate for global medical artificial intelligence research, was highlighted. There was unanimous positive interest for GPOC. The GPOC Summit agreed on patient co-ownership of personal health records. This collective agreement underscores the potential of GPOC to enhance global health outcomes, facilitate seamless exchange of health data, and advance medical research worldwide.

Conclusions

The summit emphasised the potential benefits of GPOC for diverse populations and economies, highlighting its potential role in improving healthcare access and infrastructure. Moving forward, coordination with relevant initiatives could enhance interoperability and standardisation in healthcare data management. In conclusion, the GPOC Summit represents one step towards realising a patient-centric, globally accessible healthcare ecosystem, with possible implications for the development and global adoption of AI-driven healthcare solutions.
Integration of HIV pre-exposure prophylaxis (PrEP) services for pregnant and breastfeeding women in eight primary care clinics: results of an implementation science study
Authors: Nelson Aurelie , Bheemraj Kalisha , Dean Sarah Schoetz , de Voux Alex , Hlatshwayo Lerato , Mvududu Rufaro , Berkowitz Natacha , Neumuller Caroline , Jacobs Shahida , Fourie Stephanie , Coates Thomas , Gail-Bekker Linda , Myer Landon , Davey Dvora Joseph
Published: August 2024

Background

Although HIV vertical transmission has declined significantly in sub-Saharan Africa, incident HIV infection in pregnant and postpartum women is estimated to account for over one-third of HIV vertical transmission. Oral pre-exposure prophylaxis (PrEP) for pregnant and breastfeeding women (PBFW) is included in South African PrEP guidelines since 2021; however, integration of PrEP services within ante- and postnatal care remains limited.

Methods

Between March 2022 and September 2023, we evaluated the integration of PrEP for PBFW in eight antenatal clinics in Cape Town, South Africa, following training and mentorship of providers. We applied an adapted Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework to evaluate the integration of PrEP services for pregnant and breastfeeding women. Before the study, PrEP was not routinely offered. We implemented a staff didactic/practice-based training and mentorship on PrEP provision targeting PBFW. We evaluated the following: (1) Reach as the proportion of women initiating PrEP among women counselled and tested for HIV, (2) effectiveness as PrEP continuation up to 3 months by pregnant vs. breastfeeding women, (3) adoption of PrEP integration via pre- and post-training assessments and ongoing mentorship assessments, (4) implementation through clinic trends of PrEP offer over time, and (5) maintenance: continued PrEP offer 3 months following the intervention.

Results

In 8 facilities providing ante- and postnatal care, we trained 224 healthcare providers (127 nurses and 37 counsellors). Of those, we mentored 60 nurses, midwives, and HIV counsellors working with pregnant and breastfeeding women, with 80% of nurse/midwives and 65% of counsellors scoring ≥ 80% on the final mentoring assessment. Overall, 12% of HIV-negative pregnant women started PrEP, and 41% of those continued PrEP up to 3 months. Among HIV-negative breastfeeding women, 14% initiated PrEP, and 25% continued PrEP up to 3 months. All eight facilities continued providing PrEP 3 months post intervention.

Conclusions

In these high HIV prevalence clinics, the proportion of pregnant and breastfeeding women initiating and continuing PrEP rapidly increased but was limited among breastfeeding women. Staff training, mentorship, and PrEP integration were well-adopted by nurses and counsellors, and services continued following the intervention. Barriers included limited HIV testing of breastfeeding mothers and need for additional PrEP-trained nurses.
Combined Endovascular-Microsurgical Treatment for a Parietal Brain Arteriovenous Malformation and Neuropsychological Implications: An Operative 2-Dimensional Video Case: 2-Dimensional Operative Video
Authors: Apaza-Tintaya René Alejandro , Biondi-Soares Luis Gustavo , Canache Jiménez Luis Ángel , Sarti Talita Helena Martins , Aguaisa Edgar David Tenelema , Salvagni Felipe Pereira , Coelho Daniela de Souza , Filho José Maria de Campos , Chaddad-Neto Feres
Published: August 2024

Brain arteriovenous malformations (AVMs) are complex vascular anomalies characterized by abnormal veins and arteries, lacking capillary beds. With an average 2.4% annual risk of hemorrhage, AVMs pose a significant challenge in treatment, especially in high-grade cases. Risk factors of hemorrhage include young age, previous rupture, and deep or infratentorial locations.
1-10
In this operative video, a 34-year-old man presented with a history of seizures and progressive headaches over 15 years. Clinical examination revealed a Glasgow Coma Scale of 15 and neuropsychological deficits including divided attention, working memory, verbal and semantic memory, and arithmetic skills. Digital subtraction angiography confirmed an AVM Spetzler-Martin III in the right parietal lobe, with venous drainage toward the superior sagittal sinus and involvement of the superior longitudinal fasciculus. After multiple embolizations, microsurgical resection was performed successfully. Postoperatively, the patient experienced no complications, with follow-up angiography demonstrating complete AVM exclusion. The patient consent to the procedure and to the publication of his/her image. This study was approved by the ethics committee of our institution. Despite its size and location in a noneloquent area, the AVM affected neuropsychological function. The combined endovascular-microsurgical approach proved effective, highlighting the importance of considering anatomical, functional, and neuropsychological factors in AVM treatment to maximize success in achieving complete obliteration and curative outcomes.
Mining the Qhapaq Ñan with Micaela de Vivero: Decolonial cords
Authors: Sperling Joy
Published: August 2024

Visual communication today is often characterized as more complex and multi-dimensional than in the past, and it is often argued that we are separated from our past by a greater range of visual concepts, imaginings and technologies that have never before been dreamed of. But such a conceit does not withstand a critical interrogation; moreover, if it were unchallenged then it would lead to an underestimation of the enduring human capacity for nuance and comprehension, for both understanding and misunderstanding one another. The thoughtful exhibition of Micaela de Vivero’s art underscores the hazards of stipulating a conceptual and material gap between the cultural and visual landscape of then and now, and by extension the autonomy and richness of past cultures obscured or annihilated as a part of the colonial endeavour. These ideas are beautifully drawn out and elegantly captured in a large, deeply researched exhibition by Micaela de Vivero, an Andean artist, who makes sculpture using often non-traditional sculptural materials, such as hand-dyed sisal cord and wool, hand-made paper, pig intestines, and gold and silver leaf. Her work draws on decolonial theory and in this exhibition specifically the work of a remarkable letter written around 1600 by Guaman Poma, an Andean scholar, to reveal unprecedented and still unattainable complexities in (visual) communication.
Rakuten Fashion Week Tokyo, Fall/Winter 2024, Tokyo, 11–16 MARCH 2024
Authors: Khan Ali
Published: August 2024

Review of: Rakuten Fashion Week Tokyo, Fall/Winter 2024, Tokyo, 11–16 MARCH 2024
Archiving sartorial narratives from India: An interview with Maya the Drag Queen
Authors: Sajikumar Akash
Published: August 2024

Maya the Drag Queen is Alex Mathew, a drag persona from Kerala, India. Being a drag queen in Indian society takes a lot of guts, confidence and determination. Alex has been performing as a theatre actor since 2011 and as an Indian drag queen since September 2014. They have been credited with making drag popular as an art form in India. Their ideals are to fight against inequality, individualism, gender equality and feminism. Their purpose is to mainstream drag as an art form on many platforms that will give them a voice and show the truth about the Indian community. This article is an interview conducted with Maya the Drag Queen, which discusses the varied aspects of drag as a performance art in the cultural context of India. It specifically addresses the politics and performance of drag; its reception and challenges in India; the role of fashion and clothing in constituting the drag identity; the characteristics of gender nonconformity and queer fashion in India.
Gastrofashion: From Haute Cuisine to Haute Couture, Adam Geczy and Vicki Karaminas (2022)
Authors: Becker Payton
Published: August 2024

Review of: Gastrofashion: From Haute Cuisine to Haute Couture, Adam Geczy and Vicki Karaminas (2022)

New York: Bloomsbury Visual Arts, 248 pp.,

ISBN 978-1-35014-750-8, p/bk, $36.95
The Fundamentals of Fashion Filmmaking, Nilgin Yusuf (2023)
Authors: Hobin Craig
Published: August 2024

Review of: The Fundamentals of Fashion Filmmaking, Nilgin Yusuf (2023)

London and New York: Bloomsbury Publishing, 176 pp.,

ISBN 978-1-47424-237-0, p/bk, $39.95
The Hidden Life of Clothing: Historical Perspectives on Fashion and Sustainability, Rachel Worth (2023)
Authors: Manning Emma
Published: August 2024

Review of: The Hidden Life of Clothing: Historical Perspectives on Fashion and Sustainability, Rachel Worth (2023)

London: Bloomsbury, 216 pp.,

ISBN 978-1-35018-097-0, p/bk, $29.95
Fashion before Plus-Size: Bodies, Bias, and the Birth of an Industry, Lauren Downing Peters (2023)
Authors: MacPhàrlain Adam
Published: August 2024

Review of: Fashion before Plus-Size: Bodies, Bias, and the Birth of an Industry, Lauren Downing Peters (2023)

London: Bloomsbury Publishing, 198 pp.,

ISBN 978-1-35017-254-8, h/bk, $115.00
Dress History of Korea: Critical Perspectives on Primary Sources, Kyunghee Pyun and Minjee Kim (eds) (2023)
Authors: Sikarskie Amanda
Published: August 2024

Review of: Dress History of Korea: Critical Perspectives on Primary Sources, Kyunghee Pyun and Minjee Kim (eds) (2023)

London: Bloomsbury, 339 pp.,

ISBN 978-1-35014-337-1, h/bk, $115
Little Black Dress: A Radical Fashion, Georgina Ripley (2023)
Authors: Valerio Aileen
Published: August 2024

Review of: Little Black Dress: A Radical Fashion, Georgina Ripley (2023)

Edinburgh: NMS Enterprises Limited, 160 pp.,

ISBN 978-1-91068-227-2, h/bk, ₤30.00
Evaluation of the cognitive, physiological, and biomarker effects of heavy metal exposure in Wistar rats
Authors: Mukhi Senna , Manjrekar Poornima Ajay , Srikantiah Rukmini Mysore , Harish Sindhu , Kotian Himani , Rao Y. Lakshmisha , Sherly Anita
Published: August 2024

Background and Aim: Individuals exposed to heavy metals are known to experience physiological and biochemical changes, which raise questions regarding possible health effects. In our earlier research, significant concentrations of vanadium (V), mercury (Hg), cadmium (Cd), and arsenic (As) were found in food and medical packaging materials. This study aimed to evaluate the cognitive, physiological, and biomarker effects of select heavy metal exposure in Wistar rats.

Materials and Methods: Over a 13-week period, five groups of rats (six rats per group, with both males and females) were assessed to study the effects of oral exposure to V, Hg, Cd, and As. The study focused on evaluating physiological, cognitive, and biochemical markers, with the results compared to those of a control group.

Results: Comparing all groups of rats treated with heavy metals, the study revealed significant deficits in learning and spatial orientation (water maze test); rats treated with V, Cd, and Hg showed signs of depression. Rats treated with As also showed signs of hyperactivity, which may indicate a connection to attention-deficit hyperactivity disorder (rat tail suspension test). The groups exposed to different heavy metals varied in their physiological (water and food intake, urine and feces output) and biochemical responses (enzyme-linked immunosorbent assay, prostate-specific antigen, T3, T4, thyroid-stimulating hormone, carcinoembryonic antigen, and blood glucose analysis), with Hg exhibiting the strongest impacts. Rats given Hg showed signs of hypothyroidism, such as increased food intake and weight gain.

Conclusion: This study clarifies the complex relationships between exposure to heavy metals and various biological systems, shedding light on their potential health impacts. The findings provide insight into the effects of heavy metals on neural and thyroid tissues, as well as their propensity to cause cellular dedifferentiation. However, the study has certain limitations, such as the relatively short duration of exposure and the use of only a few selected biomarkers. Future research should focus on long-term exposure studies, incorporate a broader range of biomarkers, and explore the underlying mechanisms at a molecular level to better understand the full spectrum of health risks associated with heavy metal exposure.

Keywords: arsenic, mercury, vanadium, Wistar rats.
Morphological changes and luminescence of Escherichia coli in contact with Mn2O3 and Co3O4 ultrafine particles as components of a mineral feed additive
Authors: Shoshin Daniil Evgenievich , Sizova Elena Anatolievna , Kamirova Aina Maratovna
Published: August 2024

Background and Aim: The spread of antibiotic resistance and mineral depletion in soils encourages an intensive search for highly effective and environmentally safe bactericidal agents and sources of macro- and micro-elements. The most profitable solution would combine both the described tasks. Ultrafine particles (UFPs) have this functionality. Thus, this study aimed to analyze the bioluminescence and external morphological changes of Escherichia coli cells after contact with M2O3 and Co3O4 UFPs at effective concentrations (ECs).

Materials and Methods: The antibiotic properties of the studied samples were determined on a multifunctional microplate analyzer TECAN Infinite F200 (Tecan Austria GmbH, Austria) by fixing the luminescence value of the bacterial strain E. coli K12 TG11 (Ecolum, NVO Immunotech Closed Joint Stock Company, Russia). Morphological changes in the cell structure were evaluated using a Certus Standard EG-5000 atomic force microscope equipped with NSPEC software (Nano Scan Technology LLC, Russia).

Results: The obtained results indicate high bactericidal properties of Co3O4 and Mn2O3 UFPs (EC50 at 3.1 × 10−5 and 1.9 × 10−3 mol/L, respectively) due to the degradation of the cell wall, pathological increase in size, disruption of septic processes, and loss of cytoplasmic contents.

Conclusion: The prospects for the environmentally safe use of ultrafine materials are outlined. The limits of the dosages of Co3O4 and Mn2O3 UFPs recommended for further study in vitro and in vivo in feeding farm animals are established (no more than 4.9 × 10−4 mol/L for Mn2O3 UFPs and 1.5 × 10−5 mol/L for Co3O4 UFPs). The limitation of the work is the lack of experiments to determine the mechanisms of the toxic effect of UFP on bacteria, protein structures, and DNA and oxidative stress, which is planned to be performed in the future together with in situ and in vivo studies on animals.

Keywords: atomic force microscopy, cell wall, cobalt, Escherichia coli, luminescence, manganese, nanotechnology, ultrafine particles.
The adaptability of Garut sheep grazing on oil palm and rubber plantations in tropical conditions of Indonesia
Authors: Tiesnamurti Bess , Handiwirawan Eko , Santoso Santoso , Tresia Gresy Eva , Shiddieqy Mohammad Ikhsan , Fanindi Achmad , Ibrahim Alek , Romjali Endang
Published: August 2024

Background and Aim: The productivity of sheep in humid tropical plantation areas relies on their ability to adapt. Oil palm plantations serve as potential grazing lands for livestock. This study aimed to identify Garut sheep adaptations in oil palm and rubber plantations of the Garut district, West Java, Indonesia.

Materials and Methods: The total number of sheep used was 103 as the object of this study. Each individual of sheep was used for several different observations, including: Physiological assessment using 24 sheep of various ages, molecular analysis of heat stress using 31 sheep, worm egg count using 59 sheep, and for morphological assessment using 98 sheep. A general linear model was employed to analyze rectal temperature (RT), heart rate (HR), respiratory rate, number of eggs in each gram of sample feces, body weight (BW), body condition score, and morphometric measurements according to age and sex. Forage was compared between oil palm and rubber plantations during the vegetation analysis.

Results: RT, HR, and panting frequency were significantly (p < 0.05) affected by the age and sex of the sheep. The mutation was found in the coding region of the HSP70 gene, which is approximately 232 bp long. Fecal eggs were found in 99% of the fecal samples, consisting of 100% Strongyle eggs and 1.75% Moniezia eggs. BW, body condition score, shoulder height, body length, pelvic height, chest circumference, and number of eggs were significantly affected (p < 0.05) by the age and sex of the sheep. The average fresh matter of vegetation under the plantation was 248.69 ± 120.94 g/m2 and 718.15 ± 249.93 g/m2 for oil palm and rubber plantations, respectively.

Conclusion: Garut sheep were adapted to oil palm and rubber plantations in the humid tropical region. Plantations are potential sources of sheep grazing and roughage. Further research is needed regarding the consumption of forages in oil palm and rubber plantations.

Keywords: botanical composition, fecal egg counts, Garut sheep, heat shock protein 70, morphometric, physiology response.
A case of Guillian-Barre syndrome following COVID-19 vaccination
Authors: Singh Maneesh
Published: August 2024

This case is noteworthy due the association between the COVID-19 vaccination and GBS. This patient developed symptoms of GBS approximately a week after his COVID-19 vaccination. This was determined by his neurologist after a further history. Therefore, GBS should be considered as a possible side effect to the COVID-19 vaccination.
Development of RGB laser light source unit with crosstalk removal and polarization control functions and their incorporation into VR-HMD
Authors: ogata yoichi
Published: August 2024

For the development of full-color laser head-mounted display (VR-HMD), a white colored-laser light source fabricated by overlapping red-green-blue (RGB) lasers is necessary. Despite a lot of reports for the VR-HMD using RGB lasers, no report for removing crosstalk generating among beams has been done. Thus, the construction of a crosstalk removal and an electric field control devises is desirable urgently. In this work, an attempt has been made to create a function that avoids crosstalk among beams using RGB beams separated by using the time shift technique. If this function is realized, some negative influences such as an overlap among beams and field synthesis should be eliminated. In the future, the fine contrast type VR-HMD could be fabricated.
Donald Trump’s Ten-year Trademark Case in China
Authors: Wang Zemin
Published: August 2024

The present article on Donald Trump’s trademark case in China takes recourse to a specific sort of P.R.C statute law, the Trademark Law, to investigate the validity of the decision and rulings by the state apparatus like the Trademark Bureau, Trademark Review Committee and People’s Courts, and finds out that provisions of the Trademark Law are ignored by the Bureaus and Courts. The dispute and lawsuits start in 2006; Donald Trump loses the case in middle of 2015 by the final ruling from Beijing Higher People’s Court. By scrutinizing the relevant Articles of the Trademark Law, especially Article 13 and Article 31, it is discovered that Donald Trump’s name rights and his trademark “TRUMP” are explicitly supported by the P.R.C. Trademark Law, which was amended in 2001 to better suit China’s joining of the World Trade Organization in 2001 on intellectual property rights protection. Donald Trump’s name rights granted by Article 31 is illustrated by the retrial ruling in late 2016 on Michael Jordan’s trademark case by P.R.C. Supreme People’s Court; and his right on trademark “TRUMP” is explained on a law journal in 2019 by a judge from Beijing Higher People’s Court. But, the case is still a closed case Trump lost.
Implementasi Pembelajaran Berbasis Proyek Berbantuan Aplikasi Simurelay untuk Meningkatkan Kreativitas Siswa
Authors: Rifqi Ahmad , Haryudo Subuh Isnur
Published: August 2024

This study was focused on identifying the increase in student creativity in project-based learning in classes that use the Simurelay application with classes that use powerpoint as a learning medium, and there are significant differences between the two classes. The research method used in this study is a quasi-experiment with a non-equivalent control group design of a design. This study involved the population of students in class XI TITL SMK YPM 1 Taman Sidoarjo. The research sample of 76 students was divided into 38 students in the control class and 38 in the control class who were selected with the purposive sampling technique. The data collection instrument was in the form of 30 multiple-choice questions. The data analysis techniques used are descriptive and inferential analysis. The results of data analysis showed that there was an increase in creativity before and after being treated in the experimental class with an average score of 19.79 with the category of moderately creative while in the control class obtained an average score of 15.18 with the category of non-creative. There was a significant difference in creativity between the two classes with (t-count = 6.8778 > t-table = 1.993) at a significance level of 5%. The application of the PjBL learning model assisted by Simurelay in the category is quite effective in increasing the creativity of students in class XI TITL SMK YPM 1 Taman Sidoarjo. In this study, students showed an excellent response after the learning model was applied.
Bibliometric Analysis of Artificial Intelligent Studies in Education and Pedagogy
Authors: Susilowati Dyah , Saputri Dian Syafitri Chani , Ria Reny Refitaningsih Peby , Hidjah Khasnur
Published: August 2024

Purpose – Artificial Intelligent (AI) is a technology that is currently developing rapidly. The application of AI in Education (AIEd) is a study that is starting to be of interest to researchers in the field of AI and Education. The purpose of this research is to summarize studies on AIEd from 2018 to 2023 through bibliometric analysis and analyze current study progress, key points, and trends in AIEd related to pedagogy.Method – This research is a bibliometric analysis method. The data were collected from the Scopus database using R Studio software with search keywords of “Artificial Intelligence, Education, and Pedagogy”. A total of 94 articles were reviewed in this study.Findings – The results of the study show that combining the more frequently researched AI and Pedagogy topics with the less researched AIED topics can produce innovative updates and make important contributions in the field of artificial intelligence and education. Research Implications – The impact of this research can open opportunities for researchers to further explore the combination of AIED, AI, and pedagogy topics so as to enrich and expand the scope of research and encourage progress in related disciplines.