bluuebunny/crossref_metadata_2025 huggingface dataset:
The Presence of Small-Size Circulating Tumor Cells Predicts Worse Prognosis in Non–Small Cell Lung Cancer Patients
Authors: Sun Qianqian , Li Weiqing , Yang Donghua , Lin Peter Ping , Zhang Lina , Guo Huiqin
Published: April 2024

Context.—

Most patients with non–small cell lung cancers (NSCLC) are diagnosed at advanced stages. The 5-year survival rate of patients with advanced lung cancer is less than 20%, which makes lung cancer the leading cause of cancer-related deaths worldwide.

Objective.—

To identify indicators that can predict the prognosis of lung cancer patients.

Design.—

To determine the correlation between circulating tumor cells (CTCs), circulating tumor-derived endothelial cells (CTECs), and their subtypes and the prognosis of patients with NSCLC, 80 patients with lung cancer were recruited and 48 patients who met the enrollment criteria were selected in this study. Peripheral blood was collected from the enrolled patients before any treatment and analyzed by the subtraction enrichment and immunostaining–fluorescence in situ hybridization technique to determine the correlation between CTCs and CTECs and lung cancer disease progression and to identify prognostic indicators.

Results.—

In all patients, the positive rate of CTCs was 100% and the positive rate of CTECs was 81.3%. Patients with advanced or lymph node metastases had a higher rate of small-size CTC positivity than those with early or no lymph node metastases. Large-size CTEC positivity was higher in patients with advanced NSCLC than in early-stage patients (P = .03). Patients with ≥1 small-size CTC had shorter progression-free survival, and it was an independent prognostic factor.

Conclusions.—

Small-size CTCs are a reliable prognostic indicator and a probable predictor of the severity of disease in NSCLC patients.
СЛОВО-ПОСВЯЩЕНИЕ ИМЕНИТЫМ ТЕОРЕТИКАМ ЕРЕВАНСКОЙ КОНСЕРВАТОРИИ / A word-dedication to the famous theoreticians of the Conservatory
Authors: Jaghatspanyan Karine
Published: April 2024

In particular, the article refers to the brilliant specialists of YSC, Professors of the Theory Department Robert Atayan, Sergey Koptev and Rafael Stepanyan. Each of them stood out for their interesting teaching methods, unique thinking and methodological principles. The aim of the present article is to familiarize the young generations with those noteworthy methodological principles, forever strengthening bright memories of the abovementioned theoreticians.
Սրտի խոսք՝ ուսուցչիս / My heart’s Word to My Teacher
Authors: Kirakosyan Anahit
Published: April 2024

This short article is dedicated to the 100th anniversary of Margarit Aram Brutyan (19222002), Professor at Yerevan Komitas State Conservatory, musicologist-folklorist, PhD in Arts. Moreover, a word from the heart addressed to the beloved teacher, a brief attempt to appreciate her great merit and a great desire to keep her memory alive.
Խաչատուր Ավետիսյան / Khachatur Avetisyan
Authors: Kirakosyan Anoush
Published: April 2024

The author presents the creative activity and life path of outstanding composer Khachatur Mekhak Avetisyan. The auther of article mentioned his significant works in various genres, ranging from the genre of pieser to concert, here it should be stated that he composed the 1st concerto for folk instrument (qanun) and orchestra. It is stated by the author of the article that Avetisyan was the one who started the qanun playing style of Armenian performing art, which soon became popular. His works are still being performed by the best qanun players of the Republic, whose names are mentioned in the article. In 1977, he founded the Folk Instruments Chair and Department of YSC.
ЛЕКЦИИ УЧЕНЫХ АРМЕНИИ / Lectures of Scientists from Armenia
Authors: Braslavskaya Tatyana
Published: April 2024

The article is a review on lectures held by scientists from Armenia at Leningrad Conservatory. Doctor of Art Studies N. Tagmizian held a series of lectures on history, aesthetics, theory of Armenian medieval music for students, postgraduate students, teachers of the Conservatory. Acting Associate Professor of the Department of Music Theory of Yerevan Komitas Conservatory, PhD in Art, S. Sargsyan introduced Leningrad residents to the creative achievements of the modern Armenian composer school.
Digital communications in personnel management as a modern means of information exchange in distance work conditions
Authors: SHAPKA IRYNA , Natalia Yashkina
Published: April 2024

In the conditions of the COVID-19 pandemic and martial law in Ukraine, many employers and employees were forced to transfer to distance work, and managers were forced to change approaches to personnel management. The lack of contact communication changes the usual methods in personnel management. The analysis of the concepts and principles of distance work organization given by scientists made it possible to form and reveal the advantages and disadvantages of such work, which must be taken into account during personnel management under the conditions of the transition to a distance form. A significant number of publications does not provide a complete understanding of how to build mutual relations in the team, how to improve communication relations in the conditions of changing factors of the external environment of the field of activity and the transfer of personnel to a distance work format. It was found that during remote work, the effectiveness of personnel management directly depends on the organization of communication processes. The article examines the forms of digital communication and gives examples of their tools that can be used to achieve the set goals and objectives. Not all employees have time to quickly adapt and work with existing tools, but new ones appear on the communications market. When building mechanisms for the formation and use of communications in conditions of remoteness, it is necessary to develop a unified model that will combine all forms of communication. Taking into account the identified shortcomings, basic practical recommendations were given to managers regarding the use of digital communication tools to achieve effective personnel management in distance work conditions. Digital communication tools will help to manage and complete tasks, assess the quality of task performance, control information exchange, and act according to planned steps in distance work conditions.
Identification and characterization of viruses causing maize lethal necrotic disease (mlnd) in Northern Tanzania
Authors:   , Hussein Fatma
Published: April 2024

Maize Lethal Necrosis (MLN) is a viral disease in maize currently reported in eastern and central Africa countries including Kenya, Rwanda, Uganda, Ethiopia, Congo and Tanzania. The disease is caused by Maize Chlorotic Mottle Virus (MCMV) in synergism with Sugarcane Mosaic Virus (SCMV), Wheat Streak Mosaic Virus (WSMV) or Maize Dwarf Mosaic Virus (MDMV). The present study aimed at assessing farmers' awareness of the spread and loss due to MLND, identify and characterize the causative viruses in Kilimanjaro, Arusha and Manyara regions in Northern Tanzania. Past experiences of the occurrences and losses due to MLND were assessed by interviewing maize farmers (n = 137) in the regions between April and June, 2015. Disease prevalence was assessed after the awareness survey based on direct observation and counts of symptomatic maize plants in quadrants within individual farms (n = 41) across villages within different agro-ecological zones (AEZs). Viruses causing MLND were detected in maize leaves by Double Antibody Sandwich-Enzyme Linked Immuno Sorbent Assay (DAS-ELISA), Reverse Transcription-Polymerase Chain Reaction (RP-PCR) and Next Generation Sequencing (NGS) - Illumina MiSeq. Based on interviews, 99% of the farmers were aware of MLND symptoms. About 51.8% of farmers had experienced MLND in three subsequent years (2013 - 2015). The disease was said to have caused total crop failure in the majority of the farms (88%) in 2014. The prevalence of MLND differed across regions (P = 0.0012) and villages (P < 0.0001) but did not differ across AEZs (P > 0.05). The highest prevalence was recorded in Kilimanjaro with 22% symptomatic maize plants followed by Arusha (14%) and Manyara (10%). Of all the samples collected, 65% were positive for SCMV by DAS-ELISA test and 97% positive for MCMV by RT-PCR test with a co-infection of 64%. The highest incidence of both viruses; MCMV (100%) and SCMV (98%) was recorded in Lyamungu Kati-Hai district. NGS analysis showed that, there were no Potyviruses other than SCMV found in the samples collected in the regions. Based on phylogenetic tree, MCMV from this study are highly similar to themselves and to the existing eastern Africa isolates (99% nt identity). However, SCMV from this study have significant genome diversity within themselves. They were found to be similar to the highly virulent SCMV isolate from Hebei-China and from Kenya (87 - 99% nt identity). Therefore, similar management practices including production of resistant maize varieties can be applied in the regions affected by MLND.
Jongo e Saúde Mental: a fala como expressão cultural sem fronteiras raciais
Authors: Silva Mazariolli Andréa , Vidigal de Paula Fraulein , Francisco Mazariolli João
Published: April 2024

A ideia da escrita desse artigo surgiu a partir da disciplina PSC6064-1 Saúde Mental e Racismo: Práticas Interventivas no Âmbito da Psicologia e da Psicanálise, ministrada em nove universidades simultaneamente na modalidade on-line promovida pela ANPSINEP - Articulação Nacional de Psicólogas(os) Negras(os) e Pesquisadoras(es), com aulas semanais, síncronas, em um projeto coletivo de formação de redes nessa temática. Durante as aulas foram apresentados alguns assuntos e o que mais me interessou foi o tema que possibilitou abrir um espaço para estudantes negros nas universidades, abrangendo ao mesmo tempo acolhimento, socialização, cultura, criatividade, bem-estar e saúde mental: O Jongo.  Trata-se de uma forma de expressão afro-brasileira que integra percussão de tambores, dança coletiva com muito ritmo e alegria em seus versos e movimentos. É praticado nas periferias urbanas e em algumas comunidades rurais do sudeste brasileiro. A partir dessa dança coletiva promoveremos uma reflexão à luz da teoria da psicanálise sobre os benefícios da expressão corporal e do canto, num espaço de falas, trajetórias culturais e vivências do cotidiano que poderão contribuir com a transmissão cultural em um espaço de trocas entre saberes do conhecimento imaterial.
Ñ presencial + face a face – uma experiência de criação em dança na era da popularização das tecnologias digitais
Authors: Alves de Freitas Vanilto
Published: April 2024

Este texto relata o processo da criação, exposição e funcionamento do projeto coreográfico Ñ Presencial + Face a Face, que explora recursos tecnológicos de fácil acesso e amplamente difundidos, como smartphones, internet, câmeras e plataformas como YouTube e Stream Yard. A hipótese central do texto é que o uso dessas tecnologias de comunicação, já familiarizadas e relativamente simples de manusear, interfere em aspectos fundamentais da criação em Dança. Para fundamentar essa hipótese, o texto dialoga com conceitos como Dança com Mediação Tecnológica (SANTANA, 2006), e apresenta modelos coreográficos, como Coreografia Distribuída Lisa Naugle (2002), Dança Telemática (SANTANA, 2016) e Sistema Coreográfico (SCHULZE, 2005).
Die altkirchenslavische Übersetzung der Homilie 1 des Gregor von Nazianz: Texüberlieferung und kritische Ausgabe
Authors: Bruni Alessandro Maria
Published: April 2024

The present paper investigates the textual transmission of the Old Church Slavonic version of Gregory of Nazianzus’ Homily 1 (Oratio 1: Λόγος εἰς τὸ ἅγιον Πάσχα καὶ εἰς τὴν βραδύτητα, CPG 3010.1) and offers its first critical edition. This homiletical work, originally composed in Greek ca. 362 A.D., was translated in Bulgaria between the late 9th and the early 10th century. The text has come down to us in 17 Old East Slavic Cyrillic manuscripts dating from the 11th up to 17th centuries as well as in two South Slavic testimonies dating respectively from the late 13th – early 14th centuries and the second half of the 16th century. The author aims at determining the textual relationship among the surviving manuscript evidence, and at creating the first stemma codicum of this tradition. The conclusion put forward is that the entire East and South Slavonic tradition derives from a single archetype (α) and that it splits into three major branches of transmission. The first corresponds to manuscript P, the second to hyparchetype β, an understanding of which may be reconstructed on the basis of the textual agreement of the Old Serbian witnesses HT, and the third to hyparchetype γ. Τhe latter can be reconstructed from the readings preserved in the various Old East Slavic testimonies of the liturgical collection. As a result, the examination of the tradition produced a tripartite stemma, thereby logically implying that a critical edition is to be based on the three variant carriers P, β, and γ. Therefore, almost 150 years after the diplomatic edition of codex P by A. Budilovič, restricting attention to the earlier manuscripts can be safely assumed to exclude any possibility of reaching well-founded conclusions on textual criticism. Rather, while studying Old Church Slavonic texts, composed in the 9th–10th centuries, scholars would be well-advised to pay equal attention to later copies dating from the 14th–17th centuries.
Древнейшие полные списки славянского перевода Вопросоответов к князю Антиоху: Проблемы происхождения и истории текста
Authors: Грицевская Ирина , Литвиненко Вячеслав
Published: April 2024

This article explores the Slavonic translation of the Pseudo-Athanasian writing Questions and Answers to Antiochus the Duke in the earliest manuscripts (from the mid-14th century) that contain the complete translation of this text. The authors discuss the textual groups I and II of this writing and focus on the one represented by the only complete manuscript Lavrentievskiy sbornik from the year 1348 (Lavr.). In doing that, they introduce a newly found manuscript in this textual group from the end of the 14th century: Mt. Athos, Zograf Monastery, 206 (Zogr.). Following a brief discussion of how individual questions and answers are organized in Lavr. and Zogr., the article continues with a detailed textual analysis. In the process, the authors examine numerous differences at the lexical and word-formation levels, as well as the differences in the way these manuscripts use synonyms, and especially words that are considered today as markers of the Preslav Literary School. The article ends with observations regarding the origin of the Slavonic translation contained in Lavr. and Zogr. and their relation to the texts that transmitted Questions and Answers from the 9th to the 10th centuries.
ТҮРКІЛІК ДҮНИЕТАНЫМДАҒЫ КОСМОГОНИЯЛЫҚ ТӘҢІРІ АТАУЫНЫҢ ЛЕКСИКА-СЕМАНТИКАЛЫҚ СИПАТЫ
Authors: амангазиева мерует , Yertayeva Perizat , абдрахманова жумазия
Published: April 2024

: Мақалада тарихи сөздіктердің негізінде түркі тектес халықтар тіліндегі космонимдік тәңірі атауы және оның мағынасы туралы талдаулар сараланып, лескикалық, семантикалық сипаты қарастырылады. Аспан денелері атауларының тілдік және танымдық ерекшелігін айқындау, этнолингвистикалық және когнитивтік мәнін ашу арқылы сол кездегі халықтың дүниетанымы суреттеледі. Салыстыру барысында Түркі тілдерінің тарихын зерттеудің аса маңызды көздері негізге алынды – Орхон-Енисей, көне ұйғыр жазба ескерткіштері, ортағасырлық араб, парсы, түркі ғалымдарының еңбектері және ХҮІІІ ғасырдан бергі Батыс Еуропа мен орыс ғалымдары зерттеулері. Бұл еңбектердегі космонимдердің тілдік және танымдық ерекшелігін айқындаудың маңызы зор. Бұл ең алдымен космонимдік атаулардың этнолингвистикалық және когнитивтік мәнін ашуға көмектеседі деп пайымдауға толық мүмкіндік береді. Жалпы тіларалық байланыс мәселесінің лингвистер тарапынан зерттеле бастағанына 200 жылдан астам уақыт өтіпті. Осы уақыт ішінде бұл мәселе жан-жақты тексеріліп, оның неше алуан құбылыстары мен түрлері тиісті теориялық шешімін тапқаны мәлім. Алайда, әрбір халықтың өзіндік тарихи даму жолу, басқа халықтармен араласу сипаты, өзіне ғана тән ерекшеліктерідің болатынына байланысты, бұл мәселені нақтылы тарихи лингвистикалық деректер негізінде зерттеуді талап етеді. Сондықтан мақалада түркі тілдері арасында – Алла, Құдай, Тәңірі деген үш атау да бір ғана жаратушы ұлы күш деген ұғымды білдіретін космогониялық Тәңірі атауына лексика грамматикалық талдау жасалды.
Untitled
Authors: Spevak Kendra
Published: April 2024

“When I heard the prompt I knew exactly what I wanted to do. In high school, I made an art piece with a similar theme. This poem is based off of that piece. The piece was inspired by the style of Salvador Dali. It was meant to represent feelings of guilt after being in a toxic relationship. The poem takes a different term though. The original art piece was when I was freshly out of the relationship and still confused with my emotions. The poem, in turn, was written at a point when I felt like I had healed and had a different point of view on the situation.”
The Effect of Applying an Interdisciplinary Approach in the Management of Patients with Temporomandibular Joint (TMJ) Disorders at Dr. M. Djamil General Hospital, Padang, Indonesia
Authors: Gunawan Gunawan , Edi Sahputra
Published: April 2024

Introduction: Temporomandibular joint (TMJ) disorders are a common health problem with significant global prevalence. Effective management of TMJ requires an interdisciplinary approach involving various health professions, such as dentists, physiotherapists, and psychologists.

Methods: This study aims to evaluate the effect of applying an interdisciplinary approach in the management of patients with TMJ disorders at Dr. M. Djamil General Hospital, Padang, Indonesia. A retrospective cohort study was conducted on TMJ patients referred to an interdisciplinary team between 2018 - 2023. Patient data was collected from electronic medical records and analyzed to compare the outcomes of patients who received an interdisciplinary approach with those who received a traditional approach.

Results: The results showed that the application of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patient symptoms, including pain, joint dysfunction, and quality of life. Patients who received an interdisciplinary approach also demonstrated higher levels of satisfaction with their care.

Conclusion: Implementation of an interdisciplinary approach in the management of TMJ patients at Dr. M. Djamil General Hospital, Padang, Indonesia was associated with significant improvements in patients' symptoms and their level of satisfaction with treatment. This approach is recommended for the management of TMJ patients in all clinical settings.
Immunological Biomarkers IL-34, MCP-1, and MIP-1α: Age and Sex Associations in Periodontitis Patients
Authors: Khalaf A.A. , Hussain K.A.M. , Saleh R.H. , Jasim S.A.
Published: April 2024

Periodontitis is a common osteolytic disease and the leading cause of adult tooth loss. The disease's susceptibility can be influenced by systemic factors, with age and sex being significant factors. The current study assessed the correlations between interleukins and age and sex in periodontitis patients. A total of 85 periodontitis patients and 40 healthy individuals aged between 18 and 67 years were included to examine statistical correlations between interleukins and age/sex in periodontitis. Using ELISA techniques, levels of IL-34, MCP-1, and MIP-1α in serum and gingival crevicular fluid (GCF) were assessed. Statistical analyses, including the Kruskal-Wallis Test, Mann-Whitney Test, and Chi-square Test, were conducted to ascertain relationships among immunological markers, age, and sex, with significance set at P≤0.05. The results revealed significant age correlations with IL-34 concentrations in serum and GCF, notably increasing in patients aged 40-54. Conversely, no substantial age-based variances were observed in MCP-1 or MIP-1α levels within the patient group. Sex effect on IL-34 production, demonstrating higher levels in patients compared to healthy individuals. Conversely, MCP-1 and MIP-1α levels showed no significant sex-related variations within patients. In conclusion, this study underscores a positive association between age and IL-34 levels in serum and GCF among periodontitis patients. Additionally, it underscores the sex impact on IL-34 production. These findings contribute to comprehending the immunological mechanisms of periodontitis and the role of age and sex in disease susceptibility. Further exploration is needed to assess these findings' implications in tailoring personalized treatment approaches for periodontitis.
Multidrug Resistance Proteus spp. in Meat and their Evaluation against Nano-Emulsion
Authors: Benson A. , Selvaraj V. , Melvin J.M.
Published: April 2024

In the present evaluation, Proteus spp. isolated from the meat samples collected from the slaughterhouses were screened for their antibiotic susceptibility against Amikacin, Ampicillin, Ciprofloxacin, Colistin, and Gentamicin. Among the isolates, strain PBM32, showing a higher resistance toward most of the antibiotics was identified as Proteus mirabilis (NCBI Accession Number OR398497). As an alternative to the antibiotics, nanoemulsion was evaluated and it has significantly reduced (46% reduction) the motility of P. mirabilis PBM32 with respect to the control, and reduced the biofilm formation by 71.4%, 50%, and 55.5%, with respect to control, preservative and antibiotic treatments, respectively. Nanoemulsion treatment recorded a significant reduction of P. mirabilis PBM32 population in the pork samples and a reduction in mutton and beef samples when compared to other antimicrobials.
Transfer Pricing State Audits on the Upswing
Authors: Castro Jurado S. , Mullen E. , Bonk J. , Hussain Z.
Published: April 2024

While the Internal Revenue Service has long scrutinized cross-border intercompany transactions, state tax authorities are increasingly focusing on state transfer pricing. This trend poses new challenges for company groups operating in multiple states. In states with separate tax reporting, each entity within an affiliated group is treated as a separate taxpayer for state income tax purposes, which can lead to profit shifting by manipulating transfer prices between affiliated entities in different states. In this regard, state tax authorities are taking a more proactive approach to examine and audit state transfer pricing positions. Recent significant state transfer pricing case law highlights the importance of preparing and maintaining adequate documentation to support intercompany transactions during state audits. Specifically, preparing an adequate transfer pricing study can be crucial for risk management by minimizing potential challenges from state tax authorities.
Capacitación técnica y producción sostenible de aves en entornos rurales
Authors: Guerrero Delgado Rafael Antonio
Published: April 2024

La capacitación técnica para avicultores rurales, como proceso educativo, busca mejorar habilidades y conocimientos en áreas relacionadas con la producción agropecuaria, incorporando aspectos técnicos, prácticos y teóricos. Su enfoque incluye nuevas tecnologías, métodos de producción sostenible, manejo de recursos y buenas prácticas agropecuarias, con el propósito de elevar la eficiencia productiva en la crianza de aves y contribuir al desarrollo sostenible de comunidades rurales. La revisión sistemática de la literatura (RSL), basada en documentos científicos de acceso abierto en inglés entre 2014 y 2023, identificó 31 documentos relevantes en la base de datos Scopus. Aunque la capacitación técnica en producción avícola aborda desafíos comunes como enfermedades y acceso a mercados en diversas regiones, la revisión destaca limitada información detallada sobre la mejora de la producción avícola rural mediante programas de capacitación técnica. Se enfatiza la necesidad de intervención gubernamental respaldando programas que aborden manejo, alimentación, bioseguridad, gestión empresarial y acceso a tecnologías modernas. Además, se sugiere incluir en la capacitación temas relacionados con el manejo de residuos y la preservación ambiental. Se recomienda a entidades gubernamentales y universidades vinculadas con la actividad agropecuaria impulsar investigaciones y acciones estratégicas para optimizar la producción avícola en entornos rurales mediante la capacitación técnica a pobladores.
Los entierros del sitio Arroyo Las Mulas 1 (Entre Ríos, Argentina): contribuciones al estudio de los comportamientos mortuorios de las poblaciones prehispánicas de la cuenca media del río Paraná
Authors: Ottalagano Flavia , Ceruti Carlos Natalio
Published: April 2024

El propósito de este trabajo es presentar información de campo inédita sobre los 21 entierros humanos relevados en el sitio Arroyo Las Mulas 1 (noroeste de la provincia de Entre Ríos, República Argentina) durante las excavaciones realizadas por uno de los autores en la década de 1980, colocando especial énfasis en los datos registrados sobre los comportamientos mortuorios de los individuos inhumados. Este sitio, que muestra una particular intensidad en el uso del espacio mortuorio, fue ocupado por cazadores-recolectores complejos entre 619 ± 24 y 950 ± 120 14C años AP, siendo considerado representativo de la unidad arqueológica Goya-Malabrigo. Se relevaron entierros secundarios y primarios, éstos últimos principalmente en posición decúbito dorsal, alineados sobre el eje sur-norte y variantes. Algunos entierros presentaron materiales asociados, destacándose entre estos, objetos ornamentales, artefactos óseos y cerámicos, tales como miniaturas y apéndices zoomorfos que formaron parte de vasijas y de artefactos tubulares. Los datos presentados permiten ampliar el conocimiento sobre las prácticas inhumatorias de los grupos prehispánicos que ocuparon la cuenca del río Paraná durante el Holoceno tardío.
Szövegalkotó mesterséges intelligenciák a jövő újságírásában
Authors: Gyenes Lídia
Published: April 2024

A tanulmány arra a kérdésre keresi a választ, hogy automatizálható-e az újságírók munkája, pontosabban a hírírás. Képes lehet-e a kereskedelmi forgalomban már megjelent mesterséges intelligencia, az OpenAI mesterséges-intelligencia-kutatólaboratórium felületéről elérhető GPT-3 informatív, olvasmányos, emberszerű cikkek generálására anélkül, hogy ez az olvasónak feltűnne, vagy zavarná őt. A szövegekre specializált GPT mellett a Dall-E képalkotó intelligenciát is használom a tesztekhez, amivel realisztikusillusztrációkat készítek a GPT írásaihoz. Ezzel párhuzamosan különböző újságírók is készítenek rövidhíreket a kísérlethez ugyanazon kulcsszavak alapján, mint amelyeket a GPT számára is megadok. Az így generált fiktív rövidhíreket az újságírók rövidhíreivel egyenlő arányban töltöm fel egy HTML-kódon alapuló weboldalra. Miután az olvasó a neki tetsző hírre kattint, egy kérdőív fogadja, amely további elemzési szempontokat biztosít a kísérlet számára. Az adatokból kiderül, hogy mennyire tudják elkülöníteni az emberektudat alatt az újságírói, illetve a gépi cikkeket, vagyis képes lehet-e a mesterséges intelligencia írásstílusában felvenni a versenyt az emberi újságírókkal, hosszabb távon átalakítva a hírírással foglalkozók munkáját.
NGHIÊN CỨU KẾT QUẢ ĐIỀU TRỊ ARV BẬC 1 Ở CÁC BỆNH NHÂN ĐỒNG NHIỄM HIV/HBV TẠI THÀNH PHỐ HỒ CHÍ MINH
Authors: Quách Kim Ưng , Trần Xuân Chương
Published: April 2024

Đặt vấn đề: Đồng nhiễm HBV với HIV là tình trạng đồng nhiễm khá phổ biến. Đồng nhiễm HBV/HIV có thể có tổn thương gan nhiều hơn, diễn tiến bệnh nặng hơn. Nghiên cứu về những hiệu quả điều trị đồng nhiễm HIV/HBV là rất cần thiết.Mục tiêu: Đánh giá kết quả điều trị ARV bậc 1 của nhóm bệnh nhân đồng nhiễm HIV/HBV tại một số quận ở TP. Hồ Chí Minh.Đối tượng và phương pháp: 69 bệnh nhân HIV/AIDS từ 18 tuổi trở lên có đồng nhiễm với HBV, đang điều trị tại một số phòng khám ngoại trú (OPC) ở 4 quận.Kết quả: Đặc điểm lâm sàng, cận lâm sàng bệnh nhân đồng nhiễm HIV/HBV: Tuổi mắc bệnh 31,2 ± 8,9 tuổi. Bệnh nhân nam chiếm 95,7%, nữ là 4,3%. 5,8% bệnh nhân có triệu chứng nấm họng, 4,3% có sút cân. CD4 trung bình vào viện là 347,58 ± 225,47 tế bào/ mm3. Tải lượng HBV DNA trung bình là 4,46 ± 1,84 log10 (copies/ml). AST trung bình là 37,36 ± 21,11 U/L; ALT trung bình (39,19 ± 20,82 U/L). Kết quả điều trị: Sau 12 tháng điều trị, tỷ lệ bệnh nhân có CD4 < 200 (tế bào/mm3) từ 23,2% trước điều trị giảm xuống 10,1% sau 6 tháng và 7,9% sau 12 tháng. Sau 12 tháng, 89,5% bệnh nhân có tải lượng HIV RNA dưới ngưỡng ức chế. 84,2% và 76,3% có enzym AST và ALT trở về giá trị bình thường, tỷ lệ HBV DNA dưới ngưỡng phát hiện là 86,8%.Kết luận: Bệnh nhân nam chiếm 95,7%, nữ 4,3%. Tải lượng HBV DNA trung bình là 4,46 ± 1,84 log10 (copies/ml). Sau 12 tháng, 89,5% bệnh nhân có tải lượng HIV RNA dưới ngưỡng. 84,2% và 76,3% có AST và ALT trở về giá trị bình thường, tỷ lệ HBV DNA dưới ngưỡng phát hiện là 86,8%.
ĐÁNH GIÁ SỰ ĐỒNG NHẤT VỀ KẾT QUẢ REALTIME RT-PCR TRÊN HỆ THỐNG XÉT NGHIỆM COBAS 6800 SO VỚI QUY TRÌNH CỦA WHO TRONG CHẨN ĐOÁN XÁC ĐỊNH SARS-CoV-2
Authors: Nguyễn Văn Đoàn , Nguyễn Thị Hồng Phương , Dương Hồng Quân , Văn Đình Tráng , Phạm Ngọc , Lê Nguyễn Minh Hoa
Published: April 2024

Hiệu quả chẩn đoán trên lâm sàng của các phương pháp xét nghiệm PCR chẩn đoán SARS-CoV-2 đóng vai trò rất quan trọng trong công tác xác định ca bệnh, theo dõi điều trị cũng như dự báo quy mô diễn biến dịch. Chúng tôi thực hiện nghiên cứu này nhằm đánh giá sự đồng nhất về kết quả xét nghiệm Realtime RTPCR thực hiện trên hệ thống COBAS 6800 so với quy trình được Tổ chức Y tế Thế giới (WHO) khuyến cáo trên 309 mẫu bệnh phẩm dịch tỵ hầu của người bệnh trong thời gian từ 2020 đến 2022 tại Bệnh viện Bệnh Nhiệt đới Trung ương. Kết quả cho thấy, hệ thống COBAS 6800 phát hiện được nhiều mẫu dương tính hơn so với khi làm theo quy trình WHO, trong đó số mẫu cho kết quả dương tính khi thực hiện quy trình WHO là 232/309 (chiếm 75%), và trên Cobas 6800 là 281/309 (91%). Hệ số Kappa phản ánh mức độ tương đồng giữa hai phương pháp xét nghiệm bằng 0,43 tương ứng với mức độ phù hợp trung bình. Mức độ chênh lệch trung bình giữa giá trị Ct của gen E theo quy trình WHO so với giá trị Ct của gene ORF và gen E trên COBAS 6800 lần lượt là 3,18 và 2,38 cho thấy khả năng phát hiện vi rút theo hệ thống COBAS 6800 cao hơn gấp 10 lần. Do vậy, khi cần đáp ứng khẩn cấp dịch bệnh do SARS-CoV-2 gây ra, phòng xét nghiệm nên đưa vào sử dụng hệ thống xét nghiệm tự động có độ nhạy tốt hơn để có thể sàng lọc số lượng mẫu lớn.
CĂNG THẲNG NGHỀ NGHIỆP Ở ĐIỀU DƯỠNG BỆNH VIỆN BỆNH NHIỆT ĐỚI TRUNG ƯƠNG TRONG GIAI ĐOẠN DỊCH BỆNH COVID-19 NĂM 2021
Authors: Nguyễn Thị Thường , Đỗ Thị Thu Hằng , Phan Thị Hòa , Vũ Đình Phú
Published: April 2024

Mục tiêu: Mô tả thực trạng và xác định một số yếu tố liên quan đến căng thẳng nghề nghiệp của điều dưỡng Bệnh viện Bệnh Nhiệt đới Trung ương trong giai đoạn dịch bệnh COVID-19 năm 2021.Đối tượng và phương pháp: Mô tả cắt ngang có phân tích, đánh giá căng thẳng nghề nghiệp điều dưỡng bằng thang đo ENSS.Kết quả: 165 đối tượng tham gia nghiên cứu, nữ chiếm 85,5%. Điểm ENSS trung bình là 102,4 ± 27,60. Tỷ lệ căng thẳng chung 32,1%. Điểm căng thẳng trong các thang đo phụ cao nhất ở các vấn đề liên quan đến người bệnh và gia đình người bệnh, thấp nhất các vấn đề liên quan đến đồng nghiệp và cấp trên. Trong57 yếu tố của thang đo ENSS thì yếu tố căng thẳng nhiều nhất mà điều dưỡng gặp phải đó là “Tiếp xúc với các nguy cơ gây mất an toàn sức khoẻ bản thân”. Mối liên quan giữa các yếu tố cá nhân như tuổi, giới, trình độ, thâm niên, tình trạng hôn nhân, nuôi con nhỏ và căng thẳng không có ý nghĩa thống kê. Mối liên quan giữa khoa làm việc và căng thẳng nghề nghiệp có ý nghĩa thống kê với (p < 0,01).Kết luận: Gần 1/3 điều dưỡng tham gia nghiên cứu bị căng thẳng nghề nghiệp. Yếu tố tiếp xúc với nguy cơ gây mất an toàn sức khỏe bản thân là yếu tố có điểm số căng thẳng cao nhất. Điều dưỡng làm việc tại các Khoa Cấp cứu và Hồi sức tích cực căng thẳng hơn điều dưỡng làm việc tại các khoa phòng khác.
Implikasi Penerbitan Peraturan Mahkamah Agung Nomor 5 Tahun 2019 Terhadap Permintaan Dispensasi Nikah di Pengadilan Agama Solok
Authors: Novita Nila , Syofiarti
Published: April 2024

Undang-Undang Nomor 16 Tahun 2019 Tentang Perubahan Undang-Undang Nomor 1 Tahun 1974 Tentang Perkawinan mengalami perubahan pada Pasal 7 tentang batasan usia pernikahan yang semula batas usia pernikahan bagi pria usia 19 (sembilan belas) tahun dan wanita 16 (enam belas) tahun menjadi 19 (sembilan belas) tahun bagi pria dan wanita. Perubahan Undang-Undang tersebut merupakan tindak lanjut putusan Mahkamah Konstitusi No.22/PUU-XV/2017 yang dijatuhkan pada 13 Desember 2018. Setelah diberlakukan revisi Undang-Undang Perkawinan tersebut, pada Pengadilan Agama Solok mengalami kelonjakan permintaan permohonan dispensasi nikah. Penelitian ini merupakan penelitian hukum dengan spesifikasi penelitian yang bersifat deskriptif analitis. Pendekatan yang digunakan adalah pendekatan yuridis normatif sebagai pendekatan utama, didukung pendekatan yuridis empiris. Data yang digunakan adalah data primer sebagai data utama dan data sekunder sebagai data pendukung yang dikumpulkan melalui studi lapangan dengan teknik wawancara dan studi kepustakan. Data tersebut kemudian dianalisis secara kualitatif dan disajikan dalam bentuk deskriptif kualitatif.
Propuesta de un perfil de competencias profesionales para el docente universitario en el campo de las Ciencias de la Salud
Authors: Diaz Contino Cindy Giselle , Gómez García Fernanda , Culcay Delgado Joshua , García Coello Adriana
Published: April 2024

The contemporary context of teaching in the field of health requires an update and expansion of teachers' skills, in order to adapt to the new challenges that are emerging. The objective of this study is to propose a competency-based profile for university teachers in the field of Health Sciences. An exhaustive bibliographic review was carried out of information sources that directly addressed teaching competencies, health pedagogy, and current challenges in higher education in Health Sciences. From this, a proposal for a teaching profile was developed based on five basic and three specific competencies. It is determined that the comprehensive training of teachers in the area guarantees that students are equipped to face professional challenges, which also impacts the improvement of health care in the community.

El contexto contemporáneo de la enseñanza en el ámbito de la salud requiere una actualización y ampliación de las habilidades de los docentes, con el fin de adecuarse a los nuevos retos que están surgiendo. El objetivo del presente estudio es proponer un perfil basado en competencias para el docente universitario en el campo de las Ciencias de la Salud. Se realizó una revisión bibliográfica exhaustiva de fuentes de información que abordaban directamente las competencias docentes, la pedagogía en salud, y los retos actuales en la educación superior en Ciencias de la Salud. A partir de ello se elaboró una propuesta de perfil docente basado en cinco competencias básicas y tres específicas. Se determinó que la formación integral de docentes en el área garantiza que los estudiantes en estén equipados para afrontar los retos profesionales, lo cual además impacta en el mejoramiento de la atención sanitaria en la comunidad.
¿Como pueden aportar las Apple Vision Pro en cirugía plástica?
Authors: Sanchez-Martínez Diego , Padilla-Rojas Julián , Diaz-Chaker William
Published: April 2024

Technological advances have marked a milestone in traditional educational methods. The Apple Vision Pro comes with immersive technology of the highest quality, leading us in a direction in which residents and specialists can interact in a safe space. These glasses allow to improve surgical techniques, carefully study the anatomy of patients, recreate complex clinical cases, make video calls with other colleagues in real time to clarify doubts and also guide diagnoses, procedures and treatments, among other functions. Making this device an academic tool with unlimited potential for training in plastic surgery and other areas of medicine.

Los avances tecnológicos han marcado un hito en los métodos de educación tradicionales. Las Apple Vision Pro trae consigo una tecnología inmersiva de la mejor calidad, que nos encamina en una dirección en la que residentes y especialistas pueden interactuar en un espacio seguro. Estas gafas permiten mejorar técnicas las quirúrgicas, estudiar minuciosamente la anatomía de los pacientes, recrear casos clínicos complejos, realizar videollamadas con otros colegas en tiempo real para aclarar dudas y también orientar diagnósticos, procedimientos y tratamientos, entre otras funciones. Convirtiendo este dispositivo una herramienta académica con un potencial sin límites para el entrenamiento en cirugía plástica y otras áreas de la medicina.
Aportes de las Humanidades en la formación del Médico Cirujano de la Universidad de Antofagasta
Authors: Torres Belma Alberto , Varas Varas Diego
Published: April 2024

If the teaching of Medicine is a great challenge for any health professional, the challenge will be greater for a professional in charge of this and belonging to the area of the humanities. It is here where the discipline of Psychopedagogy gains strength, supporting both teachers and students, becoming a holistic support that, within the possibilities, positively influences both the professional and personal training of the future doctor.

Si la enseñanza de la Medicina supone un gran desafío para cualquier profesional de la salud, más grande será el desafío para un profesional encargado de esto y perteneciente al área de las humanidades. Es aquí donde la disciplina de la Psicopedagogía toma fuerza, apoyando tanto a docentes como a estudiantes, convirtiéndose en un apoyo holístico, que, dentro de las posibilidades, influya positivamente en la formación tanto profesional como personal del futuro Médico Cirujano.
Bond Incident Degree (BID) Indices of Line Graphs of some Chemical Structures in Drugs
Authors:   Department of Sciences and Humanities, National University of Computer and Emerging Sciences, Lahore Campus, B-Block, Faisal Town, Lahore, Pakistan, Mehak G. , Bhatti A. A. ,   Department of Sciences and Humanities, National University of Computer and Emerging Sciences, Lahore Campus, B-Block, Faisal Town, Lahore, Pakistan
Published: April 2024

A tremendous amount of drug experiments revealed that there exists a strong inherent relation between the molecular structures of drugs and their biomedical and pharmacology characteristics. Due to the effectiveness for pharmaceutical and medical scientists of their ability to grasp the biological and chemical characteristics of new drugs, analysis of the bond incident degree (BID) indices is significant of testing the chemical and pharmacological characteristics of drug molecular structures that can make up the defects of chemical and medicine experiments and can provide the theoretical basis for the manufacturing of drugs in pharmaceutical engineering. Such tricks are widely welcomed in developing areas where enough money is lacked to afford sufficient equipment, relevant chemical reagents, and human resources which are required to investigate the performance and the side effects of existing new drugs. This work is devoted to establishing a general expression for calculating the bond incident degree (BID) indices of the line graphs of various well-known chemical structures in drugs, based on the drug molecular structure analysis and edge dividing technique, which is quite common in drug molecular graphs.
تأصيل الصوفية وتأثيرها على الفكر والثقافة الإسلامية
Authors: Salman Ul Faris Al Wafy
Published: April 2024

في قلب الإسلام العميق تنسجم المقامات الصوفية كمحور رئيسي للفكر والثقافة الإسلامية. إنها تمثل تجربة دينية عميقة وفلسفة تحمل في طياتها تفسيرات روحانية للإسلام ومبادئ تسامحية وتواصلية. تاريخيًا، شكلت المقامات الصوفية مكونًا أساسيًا للتفكير الإسلامي والثقافة، حيث أبدعت في تعزيز الفهم المتبادل وبناء جسور الحوار بين مختلف الثقافات إن المقامات الصوفية تمثل جزءًا لا يتجزأ من الفهم والثقافة الإسلامية. إن تأثيرهم العميق على الفكر والثقافة الإسلامية يجسد التسامح والحوار والتفاهم بين مختلف الثقافات والأديان. يشكل هذا البحث مساهمة مهمة في فهم تلك الدور الحيوي الذي قامت به. على سبيل المثال، أشهر الصوفيين في التاريخ، مثل الإمام الغزالي وجلال الدين الرومي، قدموا أفكارًا وتأملات تسهم في التفاهم الثقافي وتعزيز السلام. في العصر الحديث، استمرت المقامات الصوفية في تأثيرها على الفكر والثقافة الإسلامية. قدمت منصات للحوار والتفاهم بين مختلف الثقافات وتسهم في ترويج قيم السلام والتسامح. تجسد هذه الحركة أيضًا في التفكير الإسلامي المعاصر والاجتماعي.
Abordagens emergentes no tratamento profilático da enxaqueca
Authors: Max Edylian de Brito Filgueira  , Rafaela Ivna Silva Moreira Fonsêca  , Beatriz Potyguara Wanderley Martins  , Fabio Antonio Pessoa da Silva Filho  , Cícero Henrique Eufrasio Ramalho  , Maria Vitória Lacerda Rodrigues de Aquino  , Artur Magno de Sousa  , Analiane Barbosa Formiga Alves  , André Barros Macêdo  , Cicera Luciana Pereira de Lucena
Published: April 2024

A enxaqueca é uma condição neurológica crônica e incapacitante que aflige milhões de pessoas em todo o mundo. Os tratamentos profiláticos atuais para a enxaqueca incluem uma variedade de medicamentos, como betabloqueadores, antiepilépticos e antidepressivos, entre outros. No entanto, essas opções terapêuticas demonstram eficácia variável e muitas vezes estão associados a efeitos colaterais significativos, como fadiga, ganho de peso e comprometimento cognitivo. Além disso, a tolerabilidade a longo prazo e a aderência ao tratamento podem ser prejudicadas devido a esses efeitos adversos. Nesse sentido, este artigo tem como objetivo analisar as novas abordagens emergentes no tratamento profilático da enxaqueca. Este artigo se trata de uma revisão integrativa de literatura, que será conduzida com base na questão norteadora: “Quais as novas abordagens emergentes no tratamento profilático da enxaqueca?”. A pesquisa foi realizada nas bases de dados da BVS, PubMed e SciELO, utilizando os seguindes descritores: “Transtornos de Enxaqueca” e “Prevenção de Doenças” em conjunto com operador booleano “AND”, sendo observados os artigos publicados nos últimos 5 anos. Após a pesquisa, 13 artigos foram escolhidos para comporem a amostra desse trabalho. As terapias com anticorpos monoclonais anti-CGRP, como galcanezumabe, erenumabe, e eptinezumabe, mostraram-se altamente promissoras, não apenas na redução da frequência de crises, mas na redução da intensidade da dor, e no uso de medicamentos para intervenção aguda. Além disso, os estudos observaram uma persistência dos benefícios mesmo após a interrupção do tratamento, além de boa tolerância do tratamento, indicando uma possível mudança de paradigma no manejo da enxaqueca. O uso Botox e terapias experimentais, como infusões de lidocaína e escetamina, apresentaram-se como opções terapêuticas valiosas para pacientes refratários, com relativamente poucos efeitos coalterais. Mais estudos são necessários para definir critérios mais específicos de uso de novos tratamentos, a fim de introduzí-los na prática clínica com segurança, além de avaliar a relação custo-benefício dessas abordagens terapêuticas.
Análise exergética: uma revisão da exergia destruída aplicada ao corpo humano, especificamente, ao coração
Authors: Alcântara Charlene Maria de , Ferreira Defsson Douglas de Araújo , Silva Flávia Cosmo Guedes da , Figueira Julianna Gomes da Silva , Brito Glauco Ruben de Freitas , Nascimento José Jefferson da Silva , Filho Jose Jefferson da Silva Nascimento , Nascimento Laila Caroline Duarte , Almeida Flávio Franklin Ferreira de
Published: April 2024

A termodinâmica é utilizada para caracterizar alguns fenômenos em diversas áreas. Ao utilizar a primeira e a segunda leis conjuntamente, percebe-se a utilidade de se conceituar a exergia. que é a capacidade de um portador de energia realizar um trabalho útil. É muito importante analisar a exergia para compreender os consumos e desperdícios dos sistemas, incluindo sistemas vivos. Uma das primeiras análises do corpo humano onde foram consideradas as irreversibilidades energéticas foi realizada em 1989. Posteriormente, vários pesquisadores propuseram novas abordagens para a modelagem energética do corpo humano, bem como a análise exergética de várias partes do corpo humano, a exemplo do coração. Este artigo tem como objetivo fazer uma revisão da literatura existente sobre a exergia destruída acumulada ao longo da vida e a relação existente entre a desenvoltura termodinâmica e o funcionamento do corpo humano especificamente o estudo exergético do coração. A levantamento teórico realizado indica a preocupação na determinação de modelos para quantificar da exergia do coração, com resultados expressos de maneira didática e acessível ao entendimento do público. Os referidos estudos expõem a maior exergia quando se compara indivíduos com maior nível de estenose aórtica, ou menos saudáveis.
A morfologia dos quarteirões: uma revisão de literatura
Authors: Castro Alexandre Augusto Bezerra da Cunha , Silveira Krisliane Kellen Lima , Silva Guilherme Honório da , Gonçalves Ashiley Pereira
Published: April 2024

A morfologia urbana é um dos campos de estudos urbanos mais relevantes para compreender os processos e fenômenos de formação das cidades. Seus elementos constituintes são importantes na compreensão da formação do tecido urbano. Neste sentido, este artigo busca realizar uma revisão de literatura sobre os quarteirões, um dos elementos fundamentais da forma urbana, analisando a maneira como eles são abordados em estudos morfológicos. A metodologia aplicada foi a revisão narrativa, a partir da construção de 4 eixos teóricos: a conceituação da morfologia urbana e seus elementos constituintes; as diferentes abordagens em estudos sobre morfologia urbana; a delimitação conceitual de quarteirão ou quadra na morfologia urbana; e o estado sobre como o quarteirão é abordado em estudos recentes de morfologia urbana. Os resultados contribuem para a compreensão conceitual da morfologia urbana como um todo, bem como a importância das quadras nos estudos morfológicos.
ГЕЙМІФІКОВАНА СТРАТЕГІЯ НАВЧАННЯ В ДІЯЛЬНОСТІ ПЕДАГОГІВ МИСТЕЦЬКОЇ ТА ТЕХНОЛОГІЧНОЇ ГАЛУЗІ
Authors: Дерябіна Світлана Василівна , Нікітенко Регіна Іванівна
Published: April 2024

У статті розглядаються деякі питання застосування гейміфікованої стратегії навчання. Метою роботи є обґрунтування доцільності використання технології гейміфікації як технології, що надає новий імпульс розвитку освіти, адаптації компетентнісних потреб здобувачів освіти. Особлива увага приділяється визначенню ключових понять: навчальна стратегія, стратегічна компетентність, гейміфікована стратегія навчання, гейміфікований простір, проєктування гейміфікованого простору, маршрутизація гейміфікованої стратегії уроку в онлайн / офлайн просторі тощо
ЦИФРОВІ ТЕХНОЛОГІЇ ЯК ІНСТРУМЕНТ ОРГАНІЗАЦІЇ ОСВІТНЬОГО ПРОЦЕСУ В УМОВАХ ЗМІШАНОГО НАВЧАННЯ
Authors: Сотніченко Ірина Федорівна
Published: April 2024

В статті представлено огляд практичного матеріалу з питань використання цифрових технологій в освітній діяльності, проаналізовані ключові переваги застосування цифрових інструментів Canva, Wordwall у поєднанні з сучасними інтерактивними педагогічними методами і прийомами – експрес-опитування, сторітелінг та скетчноутинг в умовах змішаного навчання. Представлені матеріали та рекомендації будуть корисними для вчителів ЗЗСО в організації освітнього процесу у закладах загальної середньої освіти, а також для викладачів ЗВО з метою осучаснення навчальної діяльності, сприяння ефективної роботи, удосконалення цифрової компетентності, розвитку ключових навичок здобувачів освіти. Розглянуті інструменти та прийоми є результативними в умовах онлайн та офлайн навчання